bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Quercetin on the Intestinal Carbohydrases Activity in the Offspring of the Lead Intoxicated Mother
Authors: Kuchkarova Lubov Salijanovna , Kayumov Khasan Yusuf Ogli , Ergashev Nurali Azamovich , Kudeshovа Gulchekhra Telgenbaevna
Published: February 2024

Aim: This work aims to investigate the effect of quercetin on the development of small intestine disaccharidase activity in the offspring intoxicated with lead acetate. Material and Methods: The experiments were carried out on white outbred rats. Rats were divided into control and three experimental groups. In the control and 3rd experimental group, rats were nursed by intact mothers. In the 1st and 2nd experimental groups, rats were nursed by mothers who replaced drinking water with a 0.2% lead acetate solution. All experimental groups of rats were orally treated with quercetin (20 mg/kg/24 h) from the 3rd to 20th days of postnatal life. Body weight, small intestine weight as well as the activities of intestinal maltase and lactase were determined on the 7th, 14th, and 21st days after birth. Results: In rats nursed by mothers who used a solution of lead acetate instead of drinking water а body weight and the small intestine mucosa weight decreased, but intestinal maltase and lactase activity increased. Treatment of lead-intoxicated growing rats with quercetin restored the body weight, small intestine mucosa weight, and development rate of maltase and lactase activity. Conclusion: The effect of quercetin on the activity of intestinal maltase and sucrase in growing rats nursed by lead acetate consumed mother is mediated through the restoration of intoxication damage since treatment of intact growing rats with quercetin in the same way and at the same time did not affect on the intestinal disaccharidases activity.
Isolation, Formulation and Assessment of Anti-inflammatory Properties of Ursolic Acid from Nerium oleander
Authors: Shukla Ajay Kumar , Yadav Manish Kumar , Sharma Komal
Published: February 2024

Purpose: The purpose of the research work was the extraction and isolation of Ursolic Acid (URA) from the leaves of Nerium oleander (N. oleander) and the assessment of its anti-inflammatory activity using an in-vitro model.
Methods: Ursolic Acid (URA) is a bioactive molecule. It is a key component of N. oleander. The hydroalcoholic maceration method was used for extract preparation and was used to isolate the bioactive components of URA. The prepared extract, isolated URA were characterize and analyse by using pharmacognostic parameters, Fourier Transform Infrared (FTIR) and Thin Layer Chromatography (TLC) method. The carrageenan-induced inflammation rat paw oedema test in-vitro model was used for the assessment of anti-inflammatory properties of isolated bioactive compound URA.
Results: The results of evaluation and characterization indicated that the extract’s ash value and extractive values were within the parameters specified in the Indian Ayurvedic Pharmacopoeia. The prepared hydroalcohalic extract has potential bioactive components such as flavonoids, saponins, and triterpinoids. The isolated compound was URA. The extract may be able to alleviate inflammation, according to the percentage inhibition. Conclusion: The URA was successfully removed from the leaves of N. oleander. The examination criteria revealed that the extract contained certain small contaminants, which may have anti-inflammatory effects.
Synergic Active Principles of Medicinal Plants in Complex Remedy Makes Electro-Homeopathy — A Novel Medical System
Authors: Taki G.  S. , Sarkar Indrajit , Saha Rakhi , Mallick A. K.
Published: February 2024

The traditional herbal remedy utilises the active principles of medicinal plants, either in singular or combination. Electro-homoeopathy uses the favourable component of the active principle or medicinal properties, removing the toxic part, and using various scientific processes to prepare the remedies. To achieve faster recovery of the affected organ, Count Cesar Mattei invented a Complex herbal remedy by the Synergic mixing of the Spagyric essence of selected plants. Mattei also mentioned that a suitable complex remedy could fully cover and control the complex remedy and the affected organ. In such a complex, the toxin is eliminated by thermal, various energy-driven scientific processes, enhancing medicinal properties. A table has been designed for 114 plants to correlate the active principles/medicinal properties of the parts used in various Electro-Homeopathy remedies. The uses of the complex remedy and the remarkable clinical results obtained by the inventor and his numerous followers have been referred to in their books and reports. The basic steps of the selection of remedies in the context of affected organs and diseases are presented in the tables. The underlying Alchemical Spagyric preparation method Cohobation has been precisely addressed here.
Tolerancja na dwuznaczność a poziom zadowolenia z życia młodzieży niedowidzącej
Authors: Kędzierska Bogna
Published: February 2024

Intolerance of ambiguity (the concept formulated by E. Frenkel-Brunswik in 1948) we can concern as emotional and cognitive dimension of personality. It is characterized by seeking for certainty, clear structure and avoiding ambiguity. This article presents research analyzing, if specific experience of adolescents with low vision (who can fluctuate between seeing and not seeing and have to functioning with not clear and fragmental picture of reality) affected on their intolerance of ambiguity and haw is important the level of tolerance of ambiguity for subjective well-being.
Style atrybucji a reakcje na własną porażkę – projekt badań własnych
Authors: Jarmakowski Tomasz
Published: February 2024

The article focuses on the links between attributional style (regarded as personal trait) and succeeding, in the situation of previous failure. The attempts of research and describing these mechanisms derive from the researches of learned helplessness. To be precise from the Attributional Helplessness Model of Abramson, Seligman i Teasdale. The aim of this article is attempt to explain the lack of direct proofs between attributional styles and learned helpless arising whereas there are reliable proofs between particular attributional styles and succeeding. The article begins with survey of the most important conceptions of helplessness. Then some researches of links between succeeding and attributional styles were described. Finally the attempt of explaining the lack of direct proofs between attributional styles and learned helpless is proposed. This explanation is based on distinguishing between the situation when a lack of control is experienced (helplessness training) and the situation of experiencing single failure. The article ends with the proposal of the experiment which is planed to be a empirical verification hypothesis that individual attributional styles have relevant impact on the motivation and succeeding in the situation of previous failure.
Comunidad de Indagación y Comunidad del Común: notas para pensar la filosofía en el aula
Authors: Durán Maximiliano
Published: February 2024

El presente trabajo se propone introducir el concepto de comunidad del común en el ámbito de la didáctica de la filosofía y de la filosofía en la escuela primaria a partir de la formulación conceptual de “experiencia de pensamiento” de Walter Kohan. Desde esta presentación se sostiene que una experiencia de pensamiento construye una comunidad del común y viceversa. El texto se encuentra dividido en tres partes. En la primera parte se analiza el concepto de “experiencia de pensamiento” propuesto por Kohan, dando cuenta de la potencia y alcance de este. En la segunda sección se realiza una breve descripción del concepto de comunidad de indagación, del programa de FpN, en torno a las posibilidades y limitaciones que ofrece esta forma de comunidad. Luego de ello, se introduce el concepto de comunidad del común para resolver algunas de las limitaciones que posee la comunidad de indagación, describiendo los elementos distintivos de este tipo de comunidad. Para finalizar, recogemos las ideas centrales del trabajo y exploramos los vínculos entre experiencia de pensamiento y comunidad del común.
Prácticas Pedagógicas y usos de las tecnologías en una comunidad indígena en Colombia
Authors: Arroyo Adriana , López Solanyer
Published: February 2024

Este artículo tiene como objetivo analizar las prácticas pedagógicas y los usos de las tecnologías en una comunidad indígena en Colombia. Se adoptó la investigación acción participativa como metodología; y los talleres y entrevistas, como técnicas. Se analizan las prácticas que aún se mantienen y las que están en las memorias de la nostalgia porque se han ido olvidando y ya no son conocidas por los jóvenes y niños. Así mismo, aunque la tecnología haya alterado las dinámicas cotidianas, especialmente las de los más jóvenes, también es una oportunidad de acceso al conocimiento y de mantener las prácticas ancestrales, al deslocalizar las ideas esencialistas acerca de estas y de los propios pueblos indígenas. El eje central de la discusión es que la identidad no puede ser una trampa que fije a los indígenas al pasado y evite los diálogos interculturales, especialmente cuando sus prácticas pedagógicas se revelan como formas otras de construcción de conocimiento.
Racionalidade Antropocena e Educação Ambiental
Authors: Pereira Vilmar , Zitkoski Jaime
Published: February 2024

Esse artigo discute o conceito de racionalidade que no Ocidente orienta as leituras do Antropoceno. A partir de uma abordagem da hermenêutica filosófica, realiza esse movimento ao tomar por referência, num primeiro momento, os vestígios da racionalidade e a sua relação com a mitologia grega e demonstra sua maior expressão na modernidade europeia. Num segundo, a partir desse debate, o estudo reconhece a possibilidade de fusão entre a racionalidade moderna instrumental e o Antropoceno como Racionalidade Antropocena. A partir dos limites e da crise dessa racionalidade, sugere a perspectiva da Racionalidade Ambiental como possibilidade reconstrutiva das narrativas históricas e pedagógicas. Considera, finalmente que um dos campos em que racionalidade ambiental é muito fecunda é a Educação Ambiental, pelos movimentos reconstrutivos que já vêm realizando.
Kedudukan Suami Istri dalam Kitab Tarjuman al-Mustafid Karya Abdul Rauf al Singkili
Authors: Gunawan Gunawan , Supriyanto John , Nur Sulaiman M
Published: February 2024

This article examines Tarjuman Al-Mustafid’s interpretation of a phenomenal work by a scholar named Abdur Rauf As-Singkili Al-Fanshuri. This study focuses on the study of the concept of the role of husband and wife according to the Al-Qur’an based on the review of the tafsir Tarjuman Al-Mustafid book and the implementation of the role of husband and wife in daily life based on the concept of Al-Qur’an according to the book of tafsir Tarjuman Al-Mustafid. This research approach uses qualitative methods an the nature of the research is descriptive-analytical. The results of research on this issue are explaining the concept and implementation of the role of husband and wife in the Al-Quran study of the book of Tarjuman Al-Mustafid, Syekh Abdur Rauf said that men as leaders for women’s lives, husband and wife  must try to realize a dream marriage, namely sakinah, mawaddah and warahmah because the presence of husband and wife can bring spiritual calm to their partners by way of muasyaroh  bil ma’ruf in addressing   the lack of a partner and coming to the wife in a good way because husband and wife are like clothes to cover each other’s shortcomings in order to maintain the marriage promise with the goal of hoping for the pleasure of Allah SWT.
Aplikasi Perintah Pembayaran Mahar dalam Qur’an Surah an-Nisa’ Ayat 24-25 pada Tradisi Penyerahan Pintaan di Desa Sukaraja Kabupaten Pali dari Great Tradition ke Litle Tradition
Authors: Medy Chikita , Anshary Moh. Isa , Septiana R.A. Erika
Published: February 2024

The background in this research is that, there is still a form of confusion between religious law and customs which is a strong hold in the life of the Sukaraja community in general. In fact, there is a proverb that says “let the child die, don't die custom. This illustrates how in a custom precedes other interests in life. In the Sukaraja community, customs are still practiced, including in marriage, namely the obligation to provide an alms money as the obligation to pay a dowry. Islam is not a religion that abolishes the customs of a nation or people if that nation or people choose Islam as their religion. This is because, among the factors that cause Islam to develop in various nations and countries is because Islam does not abolish the customs or culture of a nation as long as it does not contradict Islamic principles. In this study, the background of the change in the tradition of the obligation to give money as the obligation to give a dowry is influenced by several factors, namely, assessing that the amount of money given follows the level of the bride and the social strata of the bride's family in the Sukaraja community. . The researcher uses the study of the living Qur'an, which is a scientific study in the Al-Quran that looks at social phenomena in the form of the Al-Quran that lives in the Muslim community.
Bencana Alam Perspektif Al-Qur’an Analisis Kisah Nabi Nuh, Nabi Hud dan Nabi Luth (Kajian Tematik)
Authors: Alizaky Alizaky
Published: February 2024

Disasters often afflict humans, in various forms, including hurricanes, earthquakes, floods and others. Incidents like this have happened in the past when the people were told in many verses of the Qur’an, in general this is usually closely related to the defiance of the previous ummah against the messengers of Allah SWT, immoral acts and worshiping other than Allah SWT, that means there is the relationship of every disaster that comes with human disobedience to Allah SWT. So from these problems, the writing of this thesis aims to find out "Natural Disaster Perspective of Al-Qur'an Analysis of the Story of Prophet Noah, Prophet Hud and Prophet Lut (Thematic Study)" This research is a research library or literature, which is based on two sources, namely primary sources (the holy book of al-Qur'an) and secondary sources (supporting books related to the subject). Because the method of interpretation used is a thematic or maudhui method, the steps are taken using the maudhui interpretation steps, namely tracking and compiling verses related to predetermined problems, the Makiyah and Madaniyah verses, compiling the verses coherently according to the chronology of the period of his descent, accompanied by knowledge of the background of the revelation of the verse or asbab an-nuzul, knowing the correlation (munasabah) of these verses in each of his letters, arranging the theme of the discussion in a fit, systematic, perfect and complete framework (outline ), complete the discussion and description with the hadith, if deemed necessary, so that the discussion becomes more perfect and clearer, studying these verses thoroughly and comprehensively. The results showed that the disasters that befell the people of Lut, Noah and Hud, have the same process of inviting da'wah to return to the way of Allah SWT and leaving immoral acts that have been carried out such as adultery, liking the same sex, drinking, being brutal, committing oppression, but the invitation is not accepted, the messengers of Allah SWT receive unjust treatment, so when the warning is not heard and is accompanied by repentance, then the punishment of Allah will come unexpectedly, in the form of earthquakes and fire stones the people of the Prophet Lut, the flash floods that befell the Prophet Noah and the hurricane that befell the people of Prophet Hud.
Perspektif Al-Qur’an Tentang Angin
Authors: Muslim Muslim
Published: February 2024

Wind is an important element in life on earth, both human life, animals and plants. In the Koran, wind is mentioned with the word riih in the singular form and riyah in the plural form. Various types of wind are mentioned in the Quran, among others: 'Aqiim winds, Sharshar winds,' Ashif winds, Qashif winds, Thayyibah winds, and Sakinah winds. Meanwhile, Al Quran also explains about the functions of the wind, including: helping the pollination process, moving the clouds so that it rains, moving the clouds so that it rains to fertilize the land, the wind influences the formation of sea waves, and as a warning bearer of doom.
The influence of social impact and community attribute toward tourist trust formation on social commerce in the aftermath of the COVID-19 pandemic: A case study of a tourist village in Indonesia
Authors: HANDARKHO Yonathan Dri , SULISTYANINGTYAS Ike Devi , RISMAYANTI Rebekka
Published: February 2024

Purpose – This research proposed a theoretical framework based on social impact, and community attributes theories to identify factors that influence the formation of trust among tourists towards Social Commerce (SC) utilized by a tourist village in Indonesia, particularly in the aftermath of COVID-19. In detail, this study focused on tourist village marketing through SC which emphasizes trust formation on destination readiness to welcome visitors, leading to the intention to revisit the village in the aftermath of the COVID-19 pandemic. Methodology/Design/Approach – 258 responses were obtained from Indonesian SC users interested in visiting tourist villages in Indonesia to evaluate the proposed model. The collected data were processed using confirmatory factor analysis followed by the Structural Equation Modeling (SEM) technique to analyze the direct, indirect and moderating effects of trust predictors. Findings – The results showed that endorsement by other members had the most significant positive effect on trust, followed by Quality-assured shared information and Online Bridging. In contrast to the proposed hypothesis, responsiveness had a negative impact. Although parasocial interaction and followers’ comments were rejected, the indirect effect suggests that both factors influence trust through quality-assured shared information as a mediator. Overall, the result suggests that the quality of interaction and information in SC can reduce users’ concern about the consequences of COVID-19 in a destination and thus increase users’ trust in the willingness of places to host tourists. Originality of the research – This study provides a comprehensive approach that incorporates social and community aspects that influence tourists’ trust in Social Commerce marketing of tourist destinations after the COVID-19 pandemic. As this approach has not been studied in depth before, this study contributes to filling this gap, followed by a comprehensive analysis that includes direct, indirect and moderating effects.
Laboratory Analyse for Liver Diseases Diagnosis
Authors: Chesca Antonella A
Published: February 2024

Actually, the study aimed to manage and to analyse the results of the laboratory methods, using liver samples, preparing and analizing in pathology service. This mentioned, are known as routinally practice for hepatitis C diagnosis, which conduct to hepatic cirrhosis. In this study direction, chronic liver diseases stimulate a degree of hepatocyte injury. So previously mentioned modifications, alters thet affect the liver architecture and finally ends in cirrhosis are well analyse on microscopic preparates. Folowing morphological steps, it is possible to analyse normal and alterate liver structure, on colored preparates.
The Revised Schrödinger Equation as a Solution of Measurement Paradox: A Unified Model of the U-procedure and R-procedure
Authors: Yang Yingrui
Published: February 2024

The present paper reports an alternative solution of the measurement problem in quantum theory. The measurement problem can be characterized as that the U-procedure verses the R-procedure. The R-procedure is tested by the Yes/No measurement originally proposed by von Neuman and discussed in details by Penrose. We propose a novel stochastic sampling method to tackle the measurement paradox. Each testing sample produces a pair of Yes-number c and No-number d, which in turn generates a sample phase with respect to the exponential form of (c+id). All the sample phases forms a group GR. Taking GR as the sampling potential, combined with the dynamic phase group GU，we establish a unified model of U-procedure and R-procedure for the evolution of wavefunction. Based on the Born rule, the probability of a sample is given by the squared magnitude of （c+id）. Some metaproperties of the new U-R model, such as natural transformation, consistency, and completeness, are presented. The present work provides a new picture of quantum mechanics and alike. The measurement problem widely exists in dynamic analysis, higher cognition, and large data modeling. Thus, the work reported here has a wide range of applications. Keywords: The measurement problem; U-R procedures; the Yes/No type measurement; stochastic sampling; sample phase; Born probability.
Examining TNF-Alpha Inhibition Potential: Molecular Docking Study of Pharmaceuticals and Natural Compounds
Authors: Ferrari Ivan Vito
Published: February 2024

Inflammation is a vital aspect of the body's immune response, appearing either as an acute reaction that swiftly develops (e.g., after injury or during an infection) or as a chronic condition that persists over a prolonged period, often linked with autoimmune disorders or cancer. This study introduces potential TNF-alpha inhibitors investigated by Molecular Docking investigation. They are Dactolisib with a binding energy of -10.1 kcal/mol, Nilotinib with -9.6 kcal/mol, Eltrombopag with -9.7 kcal/mol, Radotinib with -9.6 kcal/mol, and Nilotinib again with -9.7 kcal/mol. Additionally, Hypericin exhibited a notable binding energy of -9.9 kcal/mol, suggesting its potential as a natural TNF-alpha inhibitor. While these computational results are preliminary, they provide a foundation for further biological studies to confirm their efficacy. The significance of these findings extends to the scientific community, offering potential applications in the field of inflammatory diseases.
Dual-Energy CT Iodine Uptake of Head and Neck: Definition of Reference Values in a Big Data Cohort
Authors: Yel Ibrahim , Bucolo Giuseppe Mauro , Mahmoudi Scherwin , Koch Vitali , Gökduman Aynur , D'Angelo Tommaso , Grünewald Leon David , Dimitrova Mirela , Eichler Katrin , Vogl Thomas J. , Booz Christian
Published: February 2024

Abstract

Purpose
Despite a considerable amount of literature on dual-energy-CT(DECT) iodine uptake of the head and neck, the physiologic iodine uptake of this region has not been defined yet. This study aims to establish reference values for the iodine uptake of healthy organs to facilitate clinical application.

Material and Methods:
Consecutive venous DECT scans of head and neck were reviewed, and unremarkable exams were included (n=617). 35 region of interest measurements were performed in 16 anatomical regions. Iodine uptake was compared among different organs/tissues and subgroup analysis was performed (male [n=403] vs female [n=214]; young [n=207] vs middle-aged [n=206] vs old [n=204]; normal weight [n=314] vs overweight [n=196] vs obese [n=107]]).

Results:
Overall mean iodine uptake values ranged between 0.5 and 9.4mg/ml. Women showed higher iodine concentration in the cervical vessels and higher uptake for the parotid gland, masseter muscle, submandibular glands, sublingual glands, palatine tonsils, tongue body, thyroid gland, and the sternocleidomastoid muscle than men (p0.04). With increasing age, intravascular iodine concentrations increased as well as iodine uptake for cerebellum and thyroid gland, while values for tongue and palatine tonsils were lower compared to younger subjects (p0.03). Iodine concentrations for parotid glands and sternocleidomastoid muscles decreased with higher BMI (p0.004), while normal-weighted patients showed higher iodine values inside the jugular veins, other cervical glands, and tonsils versus patients with higher BMI (p0.04).

Conclusion:
Physiologic iodine uptake values of cervical organs and tissues show gender-, age-, and BMI-related differences, which should be considered in clinical routine of head and neck DECT.
PSO-CNN-Based Initial Alignment for Fiber Optic Gyroscope
Authors: Zhang Hunzhuo , Huang Duan
Published: February 2024

The exceptional performance advantages of the fiber optic gyroscope (FOG) position it as a dominant player in middle and high-end inertial navigation systems. To prevent the loss of sensor precision caused by algorithm design and simplify the complex modeling strategy in traditional methods. We gradually demonstrate the significant role of Convolutional Neural Network (CNN) in the navigation system based on FOG, and utilize the particle swarm optimization algorithm (PSO) to expedite the convergence of the network. The experimental results demonstrate that the initial alignment method based on deep learning is more accurate than the traditional method. The attitude angle error is reduced by 81.25%, 92.54% and 36.53% respectively. The research provides support for the future application of deep learning in optical navigation systems.
PRODIGY: Probing Resilience Of Domain-wall Interactions at Gauge Theory
Authors: Stephenson Matthew James
Published: February 2024

Examining the axion-dilaton model within supergravity, we focus on elucidating the construction and stability of domain walls. Emphasizing holographic vitrification action, we unveil insights into domain wall formation in gauge theories with periodic vacuum structures. Featuring a QCD-like axion term and a stabilizing dilaton, our model is scrutinized for conductivity changes under weak disorder. Notably, the system maintains perfect conductivity with a leading-order conductivity correction. Strong disorder emerges as the catalyst for transitioning to an insulator state. This study offers a comprehensive understanding of the axion-dilaton model's resilience and behavior under varying conditions.
Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil
Authors: Saivish Marielena Vogel , Nogueira Maurício Lacerda , Rossi Shannan Lee , Vasilakis Nikos
Published: February 2024

Cacipacoré virus (CPCV) was discovered in 1977 deep in the Amazon rainforest, from the blood of a black-faced ant thrush (Formicarius analis). As a member of the family Flaviviridae, genus orthoflavivirus, CPCV's intricate ecological association with vectors and hosts raises profound questions. CPCV’s transmission cycle may involve birds, rodents, equids, bovines, marsupials, non-human primates and bats as potential vertebrate hosts, whereas Culex and Aedes spp mosquitoes, have been implicated as potential vectors of transmission. The virus' isolation across diverse biomes, including urban settings suggests its adaptability as well as presents challenges for its accurate diagnosis and thus its impact on veterinary and human health. With no specific treatment or vaccine, prevention hinges on traditional arbovirus control measures. Here we provide an overview of the ecology, transmission cycles, epidemiology, pathogenesis and prevention, aiming in improving our ability to better understand this neglected arbovirus.
Sequence and Biochemical Analysis of Vaccinia Virus A32 Protein: Implications for In Vitro Stability and Coiled-Coil Motif Mediated Regulation of the DNA-Dependent ATPase Activity
Authors: Ramakrishnan Uma , Aggarwal Tanvi , Kondabagil Kiran
Published: February 2024

Nucleocytoplasmic large DNA viruses (NCLDVs) have massive genomes and particle sizes compared to other known viruses. NCLDVs, including poxviruses, encode ATPases of the FtsK/HerA superfamily to facilitate genome encapsidation. However, their biochemical and structural characteristics are yet to be discerned. In this study, we demonstrate that the viral ATPases are significantly shorter than their bacterial homologs, representing the minimal ATPase core of the FtsK/HerA superfamily. We analyzed the sequence and structural features of the vaccinia virus A32 protein and determined their roles in the stability of the A32 protein and its ATPase activity. We sought to purify A32 by various techniques and noted that recombinant A32 expressed in E. coli is highly insoluble and unstable in solution, possibly because of the disordered C-terminus. N-terminal fusion with the thioredoxin solubility tag could alleviate this issue to some extent, but subsequent tag cleavage results in increased susceptibility to precipitation and degradation. We also predicted a conserved coiled-coil motif (CCM) towards the C-terminus of VV A32. ATPase activity of A32 is known to increase in the presence of DNA. Our comparative analysis of wildtype A32 versus CCM mutants suggests that this DNA dependence of A32’s ATPase activity is likely regulated by the CCM. Since CCM is also known to facilitate protein oligomerization, these findings provide new opportunities for further detailed characterization of A32.
‘‘Genomic Insights into Knobloch Syndrome: A Meta-Analytical Perspective’’
Authors: Javed Mahnoor , Mohsin Fatima , Javed Ayesha
Published: February 2024

A rare genetic disorder caused by col18.a1 mutations, inherited mostly in autosomal recessive and rarely in autosomal dominant pattern, giving rise to ocular abnormalities and other associated disorders, the condition is referred to as Knobloch syndrome. This paper overviews the anterior and posterior ocular symptoms in Knobloch patients, thus demonstrating the major findings in Knobloch cases including the mutational analysis which discusses the proteins involved and exon number on which mutations are detected. Animal modeling done by knocking out col18.a1 has also been discussed to determine the functions of this gene which have been identified based on anomalies found in knock-out mice.
TRANS-CNN Based Gesture Recognition for mmWave Radar
Authors: Zhang Huafeng , Liu Kang , Zhang Yuanhui
Published: February 2024

In order to improve real-time performance of gesture recognition by micro-Doppler map of mmWave Radar, the point cloud based gesture recognition for mmWave Radar is proposed in this paper.Two steps are carried out for mmWave Radar based gesture recognition. The first step is to estimate the point cloud of the gestures by 3D-FFT and the peak grouping. The second step is to train the TRANS-CNN model by combining the multi-head self-attention and the 1D-convolutional network, so as to extract the features in the point cloud data at a deeper level to categorize the gestures. In the experiments, TI mmWave Radar sensor IWR1642 is used as benchmark to evaluate the feasibility of the proposed approach. The results show that the accuracy of the gesture recognition reaches 98.5%. In order to prove the effectiveness of our approach, a simply 2Tx2Rx Radar sensor is developed in our lab and the accuracy of recognition reaches 97.1%. The results show that our proposed gesture recognition approach achieves the best performance in real-time with limited training data, in comparison with the existing methods.
The Moderating Role of Corporate Governance on the Associations of Internal Audit and Its Quality With the Financial Reporting Quality: The Case of Yemeni Banks
Authors: Senan Nabil Ahmed Mareai
Published: February 2024

This study investigates the moderating effect of corporate governance on the associations of internal audit and quality of internal audit with quality of financial reporting among commercial banks in the Republic of Yemen. The final sample includes 210 internal auditors, heads of internal auditors, chairpersons, and members of audit committees. Using a survey-based methodology, the results of the Smart-PL4 analysis showed a positive association between internal audit and quality of internal audit and quality of financial reporting. Interestingly, the results showed an insignificant association between internal audit, quality of internal audit, and quality of financial reporting when considering the moderating effect of corporate governance. The findings of this study contributes valuable insights to the existing literature on the influence of internal audit, quality of internal audit, and corporate governance on quality of financial reporting in developing countries, specifically in Yemen.
Exploring Natural Compounds for Alzheimer's Disease: Virtual Screening and Docking Study with KIBRA Protein
Authors: Ferrari Ivan Vito
Published: February 2024

Therapies targeting amyloid, such as monoclonal antibodies like Lecanemab, Aducanumab, and Donanemab, have garnered FDA approval but remain controversial due to limited clinical benefits and significant side effects against Alzheimer. The present theorical work utilized Virtual Screening and Docking techniques to explore potential small natural molecules' interactions with the KIBRA protein, a promising target for drug development. Kibra protein is considered a biomarker for synaptic dysfunction and cognitive decline. Employing Autodock Vina and Pyrx software, on several natural compounds and found Hypericin to exhibit the lowest binding energy of approximately -9 kcal/mol. Previous studies have highlighted Hypericin's strong affinity for Alzheimer's Disease-associated targets like ABAD and BACE1. These findings suggest Hypericin could be as a potential therapeutic agent for Alzheimer's Disease. Further research is warranted to validate its efficacy and safety for clinical use.
Design and Parameterization of a Computational Model Based on Convolutional Neural Networks for Mango Selection
Authors: Salazar-Campos Orlando , Salazar-Campos Johonathan , Ruiz Javier Moran , Peralta José Luis , Cieza Mirian Rubio
Published: February 2024

In recent times, using image-based deep learning techniques has been very useful for classifying fruits. However, mango is a particular challenge because its shelf life is directly related to the degree of maturity at the time of harvest, which is determined mainly through the visual assessment of the operators when sorting them, doing it incorrectly, coupled with the blows and compressions exposed during storage and transport, trigger the deterioration in their quality, hence the importance of this operation. In this sense, the purpose of this study focuses on designing a computational model based on Deep Learning that uses a convolutional neural network (CNN) parameterized to select mangoes according to their color tone based on their maturity stage. A dataset was established from 201 labeled images, then a CNN architecture was built, obtaining a model on which 3 criteria were evaluated: the number of convolution and grouping layers, the resolution of the input images and the number of training epochs required. As a result, an input image resolution of 32 x 32 pixels was achieved, the process included a convolution layer followed by pooling that fed another layer that processed the results and ended in an output layer with 2 neurons under the One Hot Encoding representation. The model required 20 epochs to perfect its training, achieving 96.04 % accuracy in mango image selection. This study supports the potential of CNNs in quality analysis through mango color selection, even in uncertainty scenarios.
Prevalence, Resistance Profiles and Factors Associated with Skin and Soft-Tissue Infections at Jinja Regional Referral Hospital: A Retrospective Study
Authors: Lwigale Fahad , Kibombo Daniel , Kasango Simon Dembe , Tabajjwa Dickson , Kungu Joseph , Kalule John Bosco , Otita Morgan , Kakooza Francis , Nabukenya Immaculate , Mayito Jonathan , Rwego Innocent B.
Published: February 2024

Skin and soft-tissue infections (SSTI) are common cases of hospital-acquired infections with aetiologic agents exhibiting antimicrobial resistance (AMR). We determined the prevalence, proportion of laboratory-investigated cases, AMR-profiles, and factors associated with SSTI and multi-drug resistance (MDR). This study was based on archived data of patients suspected of SSTI from 2019-2021 at Jinja Regional Referral Hospital. The analysis involved 268 randomly selected patient reports. Prevalence of SSTI was 66.4%. Laboratory-investigated cases were 14.11%. Staphylococcus aureus (n=51) was the most isolated organism. MDR pathogens explained 47% of infections. Methicillin-resistant S. aureus was up to 44%. In addition, 61% of Gram-negatives had the potential to produce extended-spectrum beta-lactamases, while 27% were non-susceptible to carbapenems. Ward of admission was significantly associated with infection (aPR=1.78, 95% CI: 1.003-3.18, p-value=0.04). Age category (19-35) was an independent predictor for MDR infections (aPR=2.30, 95%CI:1.02-5.23, p-value=0.04). The prevalence is relatively high with MDR pathogens responsible for almost half of the infections. Routine use of culture and sensitivity testing should be done for proper infection management. Gentamicin and ciprofloxacin can be considered for empirical management of emergency SSTI suspected of S. aureus. Recognizing SSTI under the Global Antimicrobial resistance Surveillance System would lead to improved preparedness and response to AMR.
Tunable Foreground Self-Calibration Scheme for Split SAR ADC
Authors: Park Joonsung , Lee Jiwon , Abraham Jacob A , Kim Byoungho
Published: February 2024

The capacitor-mismatch among diverse defects caused by the manufacturing process variations significantly affects the linearity of capacitor-array used to implement the capacitive digital-to-analog converter (CDAC) in the successive-approximation-register (SAR) analog-to-digital converter (ADC). Accordingly, the linearity of the SAR ADC is limited by that of capacitor-array, resulting in serious yield loss. This paper proposes an efficient foreground self-calibration technique to enhance the linearity of the SAR ADCs by mitigating the capacitor-mismatch based on the split ADC architecture along with variable capacitors. In this work, two ADC channels (i.e., ADC1 and ADC2) for the split ADC architecture include their capacitive DACs (CDACs) whose binary-weighted capacitor-arrays consist of variable capacitors. A charge-sharing SAR ADC is used for each ADC channel. In the normal operation mode, their digital outputs are averaged to be the final ADC output, as in a conventional split ADC. In the calibration mode, every single binary-weighted capacitor for the two ADCs is sequentially calibrated by making parallel or/and antiparallel connection among two or thee capacitors from the two channels. For instance, because the capacitors of the CDACs ideally exhibit the binary-weighted relation as Cn=2×Cn−1, variable capacitor Cn of ADC1 can be updated to be closest to the sum of Cn−1 of ADC1 and Cn−1 of ADC2 for the calibration. For the process, the two capacitor-arrays of the two ADCs can be reconfigured to be connected to each other, so that Cn of ADC1 can be connected with two of Cn−1 of ADC1 and ADC2 in antiparallel. The two voltages at the top and the bottom plates of the CDAC are compared by a comparator of ADC1, and the comparison results are used to update Cn. This process is iterated, until Cn is in agreement with the sum of two of Cn−1. Finally, all the capacitors can be calibrated in this way to have the binary-weighted relation. The simulation results based on the proposed work with a split SAR ADC model verified that the proposed technique can be practically used, by showing that the total-harmonic-distortion and the signal-to-noise-and-distortion ratio were enhanced by 21.8-dB and 6.4-dB, respectively.
Correlation between Spring Wheat Physiological Indicators and UAV Digital Image Index in Hetao Irrigation Area
Authors: Xie Min , Luo Jun , Li Lijun , Zhang Peng , Wu Qiang , Li Mengyuan , Wang Haixia , Zhang Yongping
Published: February 2024

To accurately and non-destructively monitor the growth of spring wheat in the Hetao Irrigation Area, UAV remote sensing was employed during various fertility stages. Digital image indices from diverse fertilization treatments were calculated and compared with physiological indices to identify the most sensitive digital image indices corresponding to these indices. The study underscored the critical importance of the flowering stage in the growth of spring wheat, thus highlighting the necessity of focusing on this stage. This finding reiterated that the flowering stage was pivotal for spring wheat development in the Hetao Irrigation Area. Several digital image indices, such as GLA, R, G, INT, g, GRVI, MGRVI, RGBVI, EXG, and GRRI, exhibited a high frequency of significant correlations with physiological indices during the four primary reproductive stages of wheat. Consequently, these sensitive digital image indices during the flowering stage can more effectively characterize the physiological indices of spring wheat.
A Review of Modelling and SimulationTechniques for Life Support Systems and Queueing Systems
Authors: A Mageed Dr Ismail
Published: February 2024

This paper provides an overview of modelling and simulation methods for complex systems, including queuing and life support systems. To realize and capture every aspect of a system or situation, a model is used in place of the actual one. Using a model and simulation, we may create scenarios and make decisions. Computer experiments with the model can save costs, time, and effort once its validity has been shown. A model of the thing under study is created by computer simulation, which then runs the model on a digital computer and examines the results. It's interesting to note that a knowledge base of data includes information about predicted behaviour of the model as well as coordinated determination of external variables and parameters. Selecting the precise model creation technique is the first and most difficult task in simulation. A review of techniques used in simulation model execution (serial and parallel discrete-event simulation), simulation model analysis (calibration, validation, verification, goal-seeking), and conceptual, declarative, functional, constraint, and multimodal design are presented in this paper.
Is There a Role of Beetroot Consumption on the Recovery of Oxidative Status and Muscle Damage in Ultra-Endurance Runners?
Authors: Vilar Eva , Collado-Boira Eladio , Guerrero Carlos , Folch-Ayora Ana , Salas-Medina Pablo , Hernando Carlos , Baliño Pablo , Muriach María
Published: February 2024

(1) Background: Ultra-endurance exercise involves a high physical impact, resulting in muscle damage, inflammatory response and production of free radicals that alter the body's oxidative state. Supplementation with antioxidants, such as beetroot, may improve recovery in ultra-endurance runners. The aim of this study was to determine whether there is a correlation between the beetroot intake and the recovery of serum oxidative status, inflammatory response and muscle damage parameters after an ultra-endurance race. (2) Methods: An observational and longitudinal study was conducted by means of surveys and blood samples collected from 32 runners during the IX Penyagolosa Trails CSP® race and the two following days. The variables C-reactive protein (CRP), lactate dehydrogenase (LDH), creatine kinase (CK), the activity of the antioxidant enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the oxidative damage markers malondialdehyde (MDA), carbonyl groups (CG) and loss of muscle strength using the Squat Jump test (SJ) were analyzed to discriminate whether beetroot consumption can modulate the recovery of ultra-trail runners. (3) Results: Significant differences were observed between runners who ingested beetroot and those who did not, in terms of oxidative status, specifically in serum GPx activity at 24 and 48 hours, muscle damage variables CK and LDH and in SJ test at the finish line. Therefore, the intake of supplements containing beetroot positively influences the recovery of serum oxidative status and muscle damage after ultra-endurance running.
Diversity of the Japanese Gut Microbiome
Authors: Itagaki Tatsuki , Sakata Ken-ichiro , Hasebe Akira , Kitagawa Yoshimasa
Published: February 2024

Firmicutes and Bacteroidetes, the major phyla in the colon, have been observed in humans worldwide. Gut microbiome analyses often use the Firmicutes/Bacteroidetes ratio and principal coordinates analysis (PCoA). However, misinformation is pervasive in the human microbiome literature and analysis. An attempt was made to demonstrate how to analyze using the “National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN JMD) (Public Data).” The results showed that PCoA did not work, and principal component analysis (PCA) was useful for analyzing the gut microbiome alpha diversity.
Fundamental Study on Extraction of Sodium Tungstate from Wolframite through Pyrometallurgical Smelting
Authors: Xu Liqiang , Zhao Baojun
Published: February 2024

Tungsten is a high-value resource with a wide range of applications. The end-products of tungsten industry are tungsten metal and alloys that are produced through many steps from high-grade concentrates. Pyrometallurgical extraction of tungsten from complex and low-grade ores has great potential to overcome the problems associated with the hydrometallurgical process. In this study, sodium carbonate and silica were used to extract tungsten from wolframite at high temperatures. Sodium tungstate can be obtained directly from the smelting reaction between 1100 and 1300 oC. The smelting slag is further water-leached to recover sodium tungstate in the solution. The effects of Na2CO3/Ore and SiO2/Ore ratios, temperature and reaction time on the recovery of tungstate and the purity of sodium tungstate were systematically studied, which provides a theoretical basis for the pyrometallurgical smelting process of tungsten extraction.
Effect of Mirror Therapy on Post-Needling Pain Following Deep Dry Needling of Myofascial Trigger Point in Lateral Elbow Pain: A Controlled Pilot Trial.
Authors: Martín Pérez Sebastián Eustaquio , Rodríguez Jhoselyn Delgado , Kalitovics Alejandro , Rodríguez Pablo De Miguel , Bortolussi Daniela Sabrina , Rodríguez Villanueva Iremar , García Molina Álvaro , Ruiz Rodríguez Iván , Martín Pérez Isidro Miguel , Sosa Reina Maria Dolores , Villafañe Jorge Hugo , Alonso Pérez Jose Luis
Published: February 2024

This study aimed to investigate the effect of adding Mirror Visual Feedback Therapy (MFT) after Dry Needling (DDN) on sensitivity and motor performance in patients diagnosed with Post-Needling pain from Myofascial Trigger Points (MTrPs) in lateral elbow pain patients. A randomized, controlled, two-arm pilot trial following Consolidated Standards of Reporting Trials (CONSORT) was conducted at the European University of Madrid between February 1, 2023, and June 2, 2023. A total of 49 patients (F=23, M=26) were randomly assigned to the Experimental Group Deep Dry Needling, Ischemic Compression, Cold Spray, Stretching, and Mirror Therapy (n=25), and the others receiving the same interventions without Mirror Therapy (n=24). Pre- and post-treatment assessments encompassed Post-needling pain (VAS), pressure pain threshold (PPT), two-point discrimination threshold (TPDT), and maximum hand grip strength (MHGS). Post-needling pain intensity in the EG showed statistically significant reductions (MD = 0.400, SEM = 0.271, W = 137.00, p = 0.047) following the addition of MT to the DDN protocol. Similarly, PPT exhibited significant improvements (MD = 0.148 Kg/cm2, SEM = 0.271, W = 262.00, p < 0.001). However, TPDT and MHGS did not show significant differences between initial and post-treatment measurements. The addition of MFT to DDN for MTrPS in lateral elbow pain reduced Post-needling pain and influenced on sensory perception in lateral elbow pain patients with Myofascial Trigger Points. Despite observed clinical effects not reaching statistical significance, these findings offer valuable insights for future research considerations.