bluuebunny/crossref_metadata_2025 huggingface dataset:
Parallel Genetic Algorithms
Authors: Harada Tomohiro , Alba Enrique
Published: August 2020

In this article, we encompass an analysis of the recent advances in parallel genetic algorithms (PGAs). We have selected these algorithms because of the deep interest in many research fields for techniques that can face complex applications where running times and other computational resources are greedily consumed by present solvers, and PGAs act then as efficient procedures that fully use modern computational platforms at the same time that allow the resolution of cutting-edge open problems. We have faced this survey on PGAs with the aim of helping newcomers or busy researchers who want to have a wide vision on the field. Then, we discuss the most well-known models and their implementations from a recent (last six years) and useful point of view: We discuss on highly cited articles, keywords, the venues where they can be found, a very comprehensive (and new) taxonomy covering different research domains involved in PGAs, and a set of recent applications. We also introduce a new vision on open challenges and try to give hints that guide practitioners and specialized researchers. Our conclusion is that there are many advantages to using these techniques and lots of potential interactions to other evolutionary algorithms; as well, we contribute to creating a body of knowledge in PGAs by summarizing them in a structured way, so the reader can find this article useful for practical research, graduate teaching, and as a pedagogical guide to this exciting domain.
Boron Carbon Nitride (BCN) Nano-Coatings of Central Venous Catheters Inhibits Bacterial Colonization
Authors: Naga Varsha , Nehate Shraddha Dhanraj , Saikumar Ashwin Kumar , Sundaram Kalpathy B.
Published: August 2020

Central line associated bloodstream infections (CLABSI) are commonly induced due to bacterial colonization of medical devices such as central venous catheters (CVCs) and is leading cause of concern due to increasing hospitalization duration, costs, and morbidity. This study evaluated the efficacy of boron carbon nitride (BCN) nano-coatings on CVC for antimicrobial activity. RF magnetron sputtering technique was utilized to deposit nano-coatings of BCN on CVCs. For comparison purposes, RF magnetron sputtered TiO2 nano-coatings were also investigated. Antimicrobial activity of nano-coatings was tested against gram-positive Bacillus cereus and gram-negative Escherichia coli bacterial cells. Nanoparticle coated and uncoated catheter surfaces were studied using FE-SEM and AFM to determine if the surface characteristics correlated with anti-adhesive effects of the bacteria. Biofilm formation on uncoated and BCN coated catheters was quantified using absorbance spectrophotometry.
Gravitational effects on intracranial pressure and blood flow regulation in young men: a potential shunting role for the external carotid artery
Authors: Ogoh Shigehiko , Washio Takuro , Paton Julian F. R. , Fisher James P. , Petersen Lonnie G.
Published: August 2020

We investigated whether gravity-induced changes in intracranial pressure influence cerebral blood flow regulation in young men. We recorded extra- and intracerebral blood flow during changes in posture, and data indicate that the external carotid artery may serve as an overflow pathway to prevent cerebral hyperperfusion during increases in cerebral arterial blood pressure.
Postural control and perturbation response in aging populations: fall risk implications
Authors: Dominguez Luis
Published: August 2020

Falls are an increasing cause of mortality in an ever-growing aging population. The main factors to consider in reducing mortality rates due to falls are postural control, consisting of the vestibular, visual, and proprioceptive system, and perturbation response. This Neuro Forum article reviews recent literature highlighting the developmental changes that occur in aging populations and the possible avenues for interventions and training to mitigate fall risk.
Gallstone Dislodgement in the Airway during ERCP: A Case Report and Review of the Literature
Authors: Hurreiz Hisham , Babikir Amira , Black Edward
Published: August 2020

Endoscopic retrograde cholangiopancreatography (ERCP) is a diagnostic and therapeutic procedure with many studied complications. We are presenting a rare complication of ERCP in choledocholithiasis: gallstone dislodging into the airway upon retrieval. The patient is a 37-year-old female admitted with obstructive jaundice. She was evaluated, and her management plan included a referral for an ERCP to extract the impacted common bile duct stones. Upon retrieval of the gallstone, it fell out the basket and lodged into the airway which was confirmed on bronchoscopy and successfully retrieved. This report describes successful management of a rare but potentially dangerous complication of ERCP to remove impacted CBD stones. The possible complications of delayed removal or inability to remove gallstones from the airway have yet to be studied and reported but are likely to include recurrent chest infections, bronchiectasis, and empyema of the lung.
Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis
Authors: Wojdasiewicz Piotr , Poniatowski Łukasz A. , Kotela Andrzej , Skoda Marta , Pyzlak Michał , Stangret Aleksandra , Kotela Ireneusz , Szukiewicz Dariusz
Published: August 2020

Objective. Hemophilic arthropathy is characterized by recurrent bleeding episodes in patients with hemophilia leading to irreversible joint degeneration. The involvement of CX3CL1 (fractalkine) and its receptor CX3CR1 was observed in the pathogenesis of numerous arthritis-associated diseases. Taking this into account, we have presented a study investigating the role of the CX3CL1/CX3XR1 axis in the course of hemophilic arthropathy, including the CX3CL1-dependent expression of CD56+, CD68+, and CD31+ cells along with evaluation of articular cartilage and synovial membrane morphology. Methods. The study was carried out using cases (n=20) of end-stage hemophilic arthropathy with a severe type of hemophilia A and control cases (n=20) diagnosed with osteoarthritis. The biofluids including blood serum and synovial fluid were obtained intraoperatively for the evaluation of CX3CL1 using the ELISA test. Tissue specimens including articular cartilage and synovial membrane were similarly collected during surgery and stained immunohistologically using selected antibodies including anti-CX3CR1, anti-CD56, anti-CD68, and anti-CD31. Additionally, the analysis included the assessment of articular cartilage, synovial membrane, and blood vessel morphology. Results. In our study, we have documented increased average concentration of CX3CL1 in the blood serum of the study group (7.16±0.53 ng/ml) compared to the control group (5.85±0.70 ng/ml) without statistically significant difference in synovial fluid concentration at the same time. We have observed an increased macrophage presence with more marked proliferation and fibrosis of the synovial membrane in the study group. Remaining results such as expression of CX3CR1 presence of NK cells and larger surface area of blood vessels within the synovial membrane were noted also without statistical significance. Conclusions. This study has demonstrated collective CX3CL1/CX3CR1 axis involvement in hemophilic arthropathy pathogenesis introducing new interesting diagnostics and a therapeutic target.
Identification of Gene Mutations in Atypical Retinopathy of Prematurity Cases
Authors: Li Yian , Li Jiakai , Zhang Xiang , Peng Jie , Li Jing , Zhao Peiquan
Published: August 2020

Purpose. We have observed that some preterm infants whose fundus appears very similar to eyes with familial exudative vitreoretinopathy (FEVR) present with atypical retinopathy of prematurity (ROP). To establish a definitive diagnosis and explore the possible genetic mechanism of atypical ROP, we performed gene sequencing of these cases using next-generation sequencing technology. Methods. A retrospective review of infants who presented with atypical ROP from October 2013 to February 2017 was performed. The data included gender, gestational age at birth, birth weight, family history, systemic disorders, and age-appropriate ophthalmic examinations. Fundus fluorescein angiography (FFA) of the parents was also performed. Peripheral blood was collected from the patients and their parents to sequence genes. Gene mutations were analysed. Results. Genetic testing revealed that 9 infants had FEVR-related disease-causing gene mutations. Nine gene mutations were detected; 5 had already been reported, and the other 4 were novel. In the 18 eyes of these 9 patients, 9 eyes exhibited severe ROP. 5 cases had a positive family history. Conclusions. Gene mutations of low-density-lipoprotein receptor-related protein 5(LRP5), frizzled-4(FZD4), Norrie disease protein (NDP), and tetraspanin-12(TSPAN12) may play a role in the pathogenesis of ROP and cause atypical ROP or preterm FEVR. The fundus lesions of ROP patients with disease-causing gene mutations were more serious. ROP cases should be carefully differentiated from preterm FEVR cases.
Hepatitis B Infection and Mother‐to‐Child Transmission in Haiphong, Vietnam: A Cohort Study with Implications for Interventions
Authors: Khue Pham Minh , Thuy Linh Nguyen Thi , Vinh Vu Hai , Dung Luu Vu , Nguyen Van Bang
Published: August 2020

Background. There is little data available on HBV infection and mother‐to‐child transmission (MTCT) in Vietnam. Objective. This study is aimed at assessing the prevalence of HBV infection and the current situation of MTCT in Haiphong, Vietnam. Methods. A transversal survey of 1721 pregnant women followed by an observational prospective cohort study of 183 HBV‐infected women was conducted at Haiphong Gyneco‐Obstetric Hospital. Women were followed up up to 12‐month postpartum; use of prevention measures and the MTCT rate were evaluated. HBV infection in children was defined by a HBsAg‐positive test at 12 months of age. Results. At baseline, 183 of 1721 pregnant women (10.6%) tested HBsAg positive. Among them, 23.0% were HBeAg positive, 26.2% had a detectable load of HBV DNA, and 13.1% had a HBV DNA load ≥ 200,000 IU/mL. All women underwent MTCT prevention antiviral therapy. At delivery, 98.9% of newborns receive a HBV vaccine birth dose, and 82% received HBIG. At 12 months of age, 94.7% have received the scheduled HBV vaccines. Eight percent of infants born from followed‐up women were HBsAg positive. The mother’s HBeAg‐positive status was associated with a higher risk of HBV infection in infants. Conclusion. The HBV prevalence and MTCT rates are high in Haiphong. A strong national plan to increase the access to preventive measures and to monitor results is needed in order to decrease this prevalence.
Effect of Heat Treatment on Microstructure and Tribocorrosion Performance of Laser Cladding Ni-65 WC Coating
Authors: Liu Ze , Liu Eryong , Du Shuangming , Li Congwei , Du Huiling , Bai Yaping
Published: August 2020

The Ni-65wt%WC cladding layers were prepared on the surface of Q235 using laser cladding technology, in which the effect of heat treatment on microstructure and tribocorrosion performance was investigated. The results showed that the coating is mainly consisted of Ni, WC, and W2C, and a significant diffusion phenomenon is formed between the interfaces of WC/Ni matrix, benefited for the improvement of bonding layer between WC/Ni-based matrixes. Meanwhile, the crystallization of WC particles after heat treatment was more obvious than untreatment; the Ni matrix grain size was also grown remarkable, leading to the lower hardness and weaker plastic deformation resistance of Ni-65wt%WC coating. And the erosion results showed that the wear rate of coating gradually decreased with heat treatment temperature increasing, while brittle WC was not suitable for high impact wear conditions. Furthermore, with the increase of heat treatment temperature, the reciprocating wear performance showed that the friction coefficient and wear rate of Ni-65wt%WC coating decreased. And the friction coefficient and wear rate of the coating (700°C) in 3.5% NaCl solution were 0.15 and 4.82×10−8 mm3·N-1·m-1, respectively. Therefore, the comprehensive comparison showed that Ni-65WC coating had better performance in low impact reciprocating testing under corrosion environment, and heat treatment was helpful to further improve the tribocorrosion performance of laser cladding Ni-65wt%WC coating.
Bond Incident Degree Indices of Catacondensed Pentagonal Systems
Authors: Rao Yongsheng , Aslam Adnan , Noor Muhammad Unfowan , Almatroud A. Othman , Shao Zehui
Published: August 2020

The bond incident degree (BID) indices can be written as a linear combination of the number of edges xi,j with end vertices of degree i and j. We introduce two transformations, namely, linearizing and unbranching, on catacondensed pentagonal systems and show that BID indices are monotone with respect to these transformations. We derive a general expression for calculating the BID indices of any catacondensed pentagonal system with a given number of pentagons, angular pentagons, and branched pentagons. Finally, we characterize the CPSs for which BID indices assume extremal values and compute their BID indices.
Schisandra Inhibit Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Rats via Suppressing M2 Macrophage Polarization
Authors: Guo Zhaojuan , Li Siru , Zhang Nan , Kang Qianjun , Zhai Huaqiang
Published: August 2020

Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause and limited to the lungs. Schisandrae chinensis fructus (Wuweizi, Schisandra) is commonly used traditional Chinese medicines (TCM) for the treatment of pulmonary fibrosis, bronchitis, and other lung diseases in China. In this study, we investigated the therapeutic effect of Schisandra on IPF which is induced by bleomycin (BLM) in rats and the inhibition of alternatively activated macrophage (M2) polarization. Bleomycin‐induced pulmonary fibrosis was used as a model for IPF, and rats were given drug interventions for 7 and 28 days to evaluate the role of Schisandra in the early oxidative phase and late fibrotic phases of BLM‐induced pulmonary injury. The data showed that Schisandra exerted protective effects on BLM‐induced pulmonary injury in two phases, which were improving inflammatory cell infiltration and severe damages of lung architectures and decreasing markers of M2 subtype. In order to prove the inhibitory effect of Schisandra on M2 polarization, in vitro experiments, we found that Schisandra downregulated the M2 ratio, which confirmed that the polarization of M2 was suppressed. Moreover, Schisandra blocked TGF‐β1 signaling in AMs by reducing the levels of Smad3 and Smad4; meanwhile, the upregulation of Smad7 by Schisandra also promoted the effect of inhibition on the TGF‐β1/Smad pathway. These results demonstrate that suppression of M2 polarization by Schisandra is associated with the development of IPF in rats.
Immunosuppressive Phenotype of Esophagus Tumors Stroma
Authors: Kovaleva Olga V. , Rashidova Madina A. , Samoilova Daria V. , Podlesnaya Polina A. , Mochalnikova Valeria V. , Gratchev Alexei
Published: August 2020

Background. Tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) contribute significantly to the development of immunosuppressive properties of a tumor. In this study, we performed immunohistochemical analysis of immune cells of esophageal tumors stroma. Methods. Paraffin-embedded tissue specimens from 48 esophageal squamous cell carcinoma (ESCC) patients were retrospectively collected for immunohistochemical analysis of stromal cells. For staining of macrophages, CD68, CD163, CD206, PU.1, and iNOS were used. For T cell detection, CD8, CD3, and FOXP3 were used. Also, we performed staining for PD-L1 that can be expressed on TAMs and tumor cells. Clinicopathological and survival data were collected and analyzed using the χ2 and Fisher exact tests, Kaplan–Meier curves, and the log-rank test. The correlation analysis was performed with Spearman’s rank correlation coefficient. Results. We found that FOXP3 expression was associated with age (p=0.042) and iNOS expression was associated with the disease stage (p=0.044). In addition, FOXP3 and CD163 appeared to be markers of good prognosis (HR=0.4420, p=0.0325, and HR=0.4447, p=0.0456, respectively). Significant association between PU.1+ and CD68+ macrophages (r=0.833; p≤0.001) and between PU.1+ and CD163+ macrophages (r=0.500; p≤0.001) was established; positive association between PU.1 and CD206 expression was also observed (r=0.250; p=0.043). Conclusions. Large amounts of CD163+ macrophages and FOXP3+ Т cells appear to be markers of good prognosis of ESCC. The number of PU.1+ macrophages strongly correlates with the number of CD68+ macrophages; therefore, usage of PU.1 as a potential macrophage marker can be recommended for esophageal tumors.
Spatial-Temporal Variation of Population Aging: A Case Study of China’s Liaoning Province
Authors: Guan Dunyi , Lei Lei , Han Zenglin
Published: August 2020

With the rapid increase of the aging population in China, research on the aging phenomenon has become critical. Studying population aging from a spatial perspective is of vital practical significance. Based on China’s census data from 1990 to 2010, this study establishes the indicator system of aging level and chooses the entropy method, standard deviational ellipse, and spatial autocorrelation as main methods. Taking Liaoning province of China as an example, the study measures the aging level of its 100 districts and counties, analyzing the overall spatial movement degree, and elucidates the temporal-spatial evolution of aging development. It further discusses the spatial correlational characteristics between each county unit. The results reveal that, first, the spatial distribution of aging in Liaoning shows an unceasingly intensifying northeast-southwest pattern. County areas along the Shenyang-Dalian line show a stronger effect of aging of the whole province. Second, the average score of aging in all county areas is on the increase; the degree of aging shows an increasing trend, but the speed of aging tends to slow down. Population aging in Liaoning shows an obvious spatial heterogeneity, which is mainly manifested by regional differences, urban-rural differences, and minority differences. Third, Moran’s I index of aging level first increases and then decreases; the values are all positive. The overall spatial pattern has a positive correlation; the spatial agglomeration effect is first enhanced and then weakened. The hot spots are distributed in the surrounding counties of Shenyang and Dalian, showing a distribution pattern of two cores; the cold spots gradually form a binary structure represented by Chaoyang-Huludao and Yingkou-Panjin. The study showed the positive spatial correlation of the aging level between the county units, thereby paving the way for future research on the balanced distribution. Population aging studies will contribute to optimize the population structure and promote a virtuous circle of economy. The study showed the positive spatial correlation of the aging level between the county units, thereby paving the way for future research on the balanced distribution. Population aging studies will contribute to optimize the population structure and promote a virtuous circle of economy.
A Case of Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis
Authors: Columbus-Morales Ivan , Maahs Lucas , Husain Sanam , Gordon Stuart C. , Inamdar Kedar V. , Gonzalez Humberto C.
Published: August 2020

Hemophagocytic lymphohistiocytosis (HLH) is a rare condition characterized by a pathologic immune dysregulation resulting in extreme inflammation. Clinical manifestations are varied but can include severe multiorgan failure and death. HLH has been associated with malignancies, autoimmune diseases, and infections, such as histoplasmosis. Histoplasmosis commonly has subclinical manifestations but can also present in its disseminated form. We present the case of an immunocompromised patient with worsening liver function caused by hepatic histoplasmosis that later triggered HLH with severe multiorgan dysfunction.
Hope of Recovery in Patients in the Terminal Phase of Cancer under Palliative and Hospice Care in Poland
Authors: Baczewska Bożena , Block Bogusław , Kropornicka Beata , Niedzielski Antoni , Malm Maria , Łukasiewicz Jacek , Wojciechowska Krystyna , Poleszak Wiesław , Zwolak Agnieszka , Makara-Studzińska Marta
Published: August 2020

Introduction. The objective of the presented research is to characterize hope in the situational dimension, i.e., health, in the patients with cancer in the terminal phase of the disease, being treated in hospices and palliative care centers. Hope is very important for all the patients, especially for patients with cancer in various phases of the disease. Giving up on oncologic therapy and causal treatment is often associated with a transition into palliative care. When death and a loss of values become a threat, the individual has got hope to rely on. Material and Methods. The study relies on the Test to Measure Hope in the Health Context (NCN‐36) by B.L. Block. 246 patients in the terminal phase of cancer participated in the study. Results. The internal structure of hope of recovery in the patients’ group was varied. The patients showed low levels of hope of recovery since they do not believe in the effectiveness of treatment. They were also not convinced of the effectiveness of modifications in dieting, lifestyle, or the use of nonconventional medicine. They trusted the doctor in charge and were moderately satisfied with the therapy in use. The intensity of hope of recovery was on the low level in the patients in the terminal phase of cancer. Age, sex, place of living, and marital status had a significant influence on the level of hope of recovery. Variables such as living on one’s own or living with one’s family, socioeconomic status, education, or profession did not affect the level of hope of recovery. Conclusions. The presented results allowed as to conclude that the assessment of hope in terminally ill cancer patients can be considered as one of the important tools enabling the personalization and the improvement of palliative care.
Influence of Different Pigmentations and Accelerated Aging on the Hardness and Tear Strength of the A-2186 and MDX4-4210 Silicones
Authors: Marrega Malavazi Estefânia , dos Santos Daniela Micheline , de Moraes Melo Neto Clóvis Lamartine , Pereira de Caxias Fernanda , Freitas da Silva Emily Vivianne , Bannwart Lisiane Cristina , Pesqueira Aldiéris Alves , de Melo Moreno André Luiz , de Magalhães Bertoz André Pinheiro , Goiato Marcelo Coelho
Published: August 2020

Objective. To evaluate the influence of different pigmentations and accelerated aging on the hardness and tear strength of the A-2186 and MDX4-4210 silicones. Materials and Methods. The samples A-2186 and MDX4-4210 were manufactured without and with pigmentations (black, bronze, and pink). For the Shore A hardness test, 80 samples of each silicone were fabricated, and for the tear strength test, 320 samples of each silicone were fabricated. Eight groups were created for each test (n = 10). These tests were performed before and after 252, 504, and 1008 hours of aging. Three-way repeated-measures analysis of variance and the Tukey test were performed (α = 0.05). Results. The A-2186 silicone showed higher hardness and tear strength when compared with the MDX4-4210 silicone p<0.05, except in the hardness of the A-2186 and MDX4-4210 groups without pigmentation after 1008 hours p>0.05. All hardness values were between 25 and 35 units, regardless of the silicone type, period, and pigmentation (or no pigmentation). In most situations, the hardness of silicones used increased after 252 hours p<0.05. The nonpigmented MDX4-4210 group and all A-2186 groups showed an increase in tear strength after 252 hours p<0.05. For the nonpigmented MDX4-4210 group, from 252 to 1008 hours, there was no change in tear strength p>0.05. All pigmented MDX4-4210 groups showed no change in tear strength from 0 (initial) to 1008 hours of aging p>0.05. In all A-2186 groups, from 252 to 504 hours, there was a reduction in tear strength p<0.05, and from 504 to 1008 hours, there was an increase in tear strength p<0.05, except in the bronze A-2186 group p>0.05. Conclusion. In most situations, the A-2186 silicone showed significantly higher values of hardness and tear strength than the MDX4-4210 silicone. All hardness values were considered clinically acceptable. Accelerated aging could increase, decrease, or not significantly change the hardness and tear strength of the silicones used. The results of hardness and tear strength suggest that MDX4-4210 was more influenced by the presence of pigmentation after aging.
General Log-Linear Weibull Model Combining Vibration and Temperature Characteristics for Remaining Useful Life Prediction of Rolling Element Bearings
Authors: Lv Mingzhu , Liu Shixun , Su Xiaoming , Chen Changzheng
Published: August 2020

In industrial applications, the vibration and temperature measurements of rolling element bearings are known as two popular condition monitoring methods. The previously published method for remaining useful life (RUL) prediction has been limited to using the vibration signal. However, a single signal source cannot fully reflect the degradation trend of bearings, influencing the RUL prediction precision. In this paper, a novel general log-linear Weibull (GLL-Weibull) model is constructed by considering vibration and temperature condition monitoring signals to estimate the model parameters. During the feature extraction stage, the relative root mean square (RRMS) is derived from the monitored vibration signal, and the relative temperature trend value is extracted from the monitored temperature signal to eliminate individual differences in bearings and random signal fluctuations. Then, a fuzzy operator is introduced to describe the degree of an “overheated bearing” and “excessive bearing vibrations.” During the RUL prediction stage, both the extracted vibration and temperature characteristics are used to create the GLL-Weibull model. The best parameters are attained by employing the maximum likelihood estimation approach. The algorithm performance is checked with criteria like the root mean square error (RMSE) and the mean absolute percentage error (MAPE). The effectiveness and superiority of the presented approach are validated by two real-life prognosis cases. According to the experimental results, the presented approach provides superior prediction precision and lower computational cost than other approaches for bearings under constant or variable operating conditions.
Takotsubo Cardiomyopathy in Dextrocardia with Situs Inversus
Authors: Ganes A. , Segan L.
Published: August 2020

Takotsubo cardiomyopathy (TTC) is an acute reversible form of left ventricular (LV) systolic dysfunction extending beyond a coronary artery vascular territory usually due to physical or psychological stressors. Dextrocardia with situs inversus is a rare embryologic anomaly whereby the heart and aorta are mirrored on the contralateral side. We describe a case of a 93-year-old female with dextrocardia who presented with chest pain, atrial fibrillation with rapid ventricular response, and transient inferior ST elevation. Coronary angiography demonstrated an eccentric mid right coronary artery (RCA) lesion and apical ballooning consistent with concurrent takotsubo cardiomyopathy (TTC). To our knowledge, this is the first reported case of this dual pathology in a patient with dextrocardia, highlighting the procedural and diagnostic complexity in the setting of a rare anatomicvariant.
Closed-Form Distance Estimators under Kalman Filtering Framework with Application to Object Tracking
Authors: Shin Vladimir , Shevlyakov Georgy , Jeong Woohyun , Kim Yoonsoo
Published: August 2020

In this paper, the minimum mean square error (MMSE) estimation problem for calculation of distances between two signals via the Kalman filtering framework is considered. The developed algorithm includes two stages: the Kalman estimate of a state vector computed at the first stage is nonlinearly transformed at the second stage based on a distance function and the MMSE criterion. In general, the most challenging aspect of application of the distance estimator is calculation of the multivariate Gaussian integral. However, it can be successfully overcome for the specific metrics between two points in line, between point and line, between point and plane, and others. In these cases, the MMSE estimator is defined by an analytical closed-form expression. We derive the exact closed-form bilinear and quadratic MMSE estimators that can be effectively applied for calculation of an inner product, squared norm, and Euclidean distance. A novel low-complexity suboptimal estimator for special composite functions of linear, bilinear, and quadratic forms is proposed. Radar range-angle responses are described by the functions. The proposed estimators are validated through a series of experiments using real models and metrics. Experimental results show that the MMSE estimators outperform existing estimators that calculate distance and angle in nonoptimal manner.
Continuous Regularized Least Squares Polynomial Approximation on the Sphere
Authors: Zhou Yang , Kong Yanan
Published: August 2020

In this paper, we consider the problem of polynomial reconstruction of smooth functions on the sphere from their noisy values at discrete nodes on the two-sphere. The method considered in this paper is a weighted least squares form with a continuous regularization. Preliminary error bounds in terms of regularization parameter, noise scale, and smoothness are proposed under two assumptions: the mesh norm of the data point set and the perturbation bound of the weight. Condition numbers of the linear systems derived by the problem are discussed. We also show that spherical tϵ-designs, which can be seen as a generalization of spherical t-designs, are well applied to this model. Numerical results show that the method has good performance in view of both the computation time and the approximation quality.
Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer
Authors: Liang Liang , Zhu Jin-hui , Chen Gang , Qin Xin-gan , Chen Jun-qiang
Published: August 2020

The “A Disintegrin and Metalloproteinase with Thrombospondin Motif” (ADAMTS) family of genes is involved in the occurrence and development of different cancers. However, the prognostic value of these genes in gastric cancer (GC) has not been revealed. The present study was thus conducted to determine the prognostic value for the ADAMTS family of genes in GC. First, we evaluated the mRNA expression levels of the ADAMTS family in GC patients using a GEPIA dataset. Thereafter, we determined the prognostic value of these genes by analyzing their mRNA level using the Kaplan–Meier Plotter database. The mRNA expression level of ADAMTS12 was randomly validated by qRT-PCR and meta-analysis while its coexpression genes were derived using Coexpedia. Finally, we performed Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses using the OmicShare Tools. Compared to normal tissues, expression of ADAMTS2 and 12 was significantly higher while that of ADAMTS1, 13, and 15 was significantly lower in GC tissues. According to the RNA-seq and gene chip data, the ADAMTS family (6, 7, 12, 15, and 18) of genes was closely related to the prognosis of GC, and their high expression levels were associated with poor prognosis and survival time. In addition, ADAMTS12 was highly expressed in 20 pairs of GC tissues based on RT-PCR (P=0.016) and meta-analysis (SMD: 0.73, 95% CI: 0.32–1.14, P<0.001). GO and KEGG pathway analyses indicated that the ADAMTS12 coexpressed genes were enriched in the pathways of extracellular matrix organization, extracellular matrix structural constituent, extracellular matrix, and protein digestion and absorption. Herein, we discovered the prognostic values and biological roles of the ADAMTS genes in GC.
Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy
Authors: Li Xinyu , Li Meng , Tian Lige , Chen Jianan , Liu Ronghan , Ning Bin
Published: August 2020

Astrocytes are the most populous glial cells in the central nervous system (CNS). They are essential to CNS physiology and play important roles in the maintenance of homeostasis, development of synaptic plasticity, and neuroprotection. Nevertheless, under the influence of certain factors, astrocytes may also exert detrimental effects through a process of reactive astrogliosis. Previous studies have shown that astrocytes have more than one type of polarization. Two types have been extensively researched. One is a damaging change that occurs under inflammation and has been termed A1 astrocyte, while the other is a restorative change that occurs under ischemic induction and was termed A2 astrocyte. Researchers are now increasingly paying attention to the role of astrocytes in spinal cord injury (SCI), degenerative diseases, chronic pain, neurological tumors, and other CNS disorders. In this review, we discuss (a) the characteristics of polarized astrocytes, (b) the relationship between astrocyte polarization and SCI, and (c) new implications of reactive astrogliosis for future SCI therapies.
Increased Cancer Risk in Families with Pediatric Cancer Is Associated with Gender, Age, Diagnosis, and Degree of Relation to the Child
Authors: Stjernfelt Karl-Johan , von Stedingk Kristoffer , Wiebe Thomas , Hjorth Lars , Kristoffersson Ulf , Stenmark-Askmalm Marie , Olsson Håkan , Øra Ingrid
Published: August 2020

Background:

Studies of cancer risk among relatives of children with cancer beyond parents and siblings are limited. We have investigated the cancer risk up to the third degree of relation in families with pediatric cancer to reveal patterns of inheritance.

Methods:

A single-center cohort of 757 patients with pediatric cancer was linked to the Swedish National Population Register, resulting in 16,137 relatives up to the third degree of relation. All relatives were matched to the Swedish Cancer Register, and standard incidence ratios (SIR) were calculated to define relatives at risk.

Results:

Children and adults up to the third degree of relation had increased cancer risk, with SIRs of 1.48 (P = 0.01) and 1.07 (P < 0.01), respectively. The SIRs for first- and third-degree adult relatives were 1.22 and 1.10, respectively, but no increased risk was observed in second-degree relatives. Male relatives had a higher risk than females, especially when related to a girl and when the child had leukemia. The risk was mainly increased for lung, prostate, and gastrointestinal cancer. When excluding 29 families of children with known pathogenic germline variants, the increased risk remained.

Conclusions:

Relatives to children with cancer up to third degree of relation have an increased cancer risk. Known pathogenic germline variants do not explain this increased risk.

Impact:

The overall increased cancer risk among relatives of children with cancer in this population-based cohort strengthens the importance of surveillance programs for families with pediatric cancer.
Effectiveness of Population-Based Service Screening with Mammography for Women Aged 70–74 Years in Sweden
Authors: Mao Zheng , Nyström Lennarth , Jonsson Håkan
Published: August 2020

Background:

Consensus has been reached on the effectiveness of inviting women aged 50 to 69 years to mammography screening, but for older women, the evidence is scarce. The aim of this study was to estimate the marginal effectiveness of inviting women to mammography screening with an upper age limit of 74 years versus stopping at age 69 using data from the Swedish service-screening program.

Methods:

A cohort design was used to compare the breast cancer mortality in the period 1986 to 2012 between geographic areas and periods where women were invited to screening up to the age of 74 years (study group) with those where women were invited up to age 69 (control group). The study group and the control group were compared using the incidence-based breast cancer mortality rate ratio where only breast cancer deaths in cases diagnosed at 70 to 74 years of age were counted.

Results:

After 20 years of follow-up, there were 1,040 and 1,173 breast cancer deaths in the study and the control group, respectively. The breast cancer mortality rate ratio for women invited up to age 74 versus women invited up to age 69 was 0.80 [95% confidence interval (CI): 0.75–0.85] after bias adjustments. The corresponding rate ratio for participating women was 0.73 (95% CI: 0.66–0.81).

Conclusions:

Continuing to screen women up to 74 years of age is effective compared with stopping screening at 69 years.

Impact:

This large long-term study will add to the knowledge of the effect of mammography screening for women 70 to 74 years.
Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of HOXA9 and MEIS1 Expression
Authors: Walker Alison R. , Byrd John C. , Blachly James S. , Bhatnagar Bhavana , Mims Alice S. , Orwick Shelley , Lin Tara L. , Crosswell Howland E. , Zhang Danjie , Minden Mark D. , Munugalavadla Veerendra , Long Lauren , Liu Jinfeng , Pan Yang , Oellerich Thomas , Serve Hubert , Rao Arati V. , Blum William G.
Published: August 2020

Purpose:

Spleen tyrosine kinase (SYK) signaling is a proposed target in acute myeloid leukemia (AML). Sensitivity to SYK inhibition has been linked to HOXA9 and MEIS1 overexpression in preclinical studies. This trial evaluated the safety and efficacy of entospletinib, a selective inhibitor of SYK, in combination with chemotherapy in untreated AML.

Patients and Methods:

This was an international multicenter phase Ib/II study, entospletinib dose escalation (standard 3+3 design between 200 and 400 mg twice daily) + 7+3 (cytarabine + daunorubicin) in phase Ib and entospletinib dose expansion (400 mg twice daily) + 7+3 in phase II.

Results:

Fifty-three patients (n = 12, phase Ib and n = 41, phase II) with previously untreated de novo (n = 39) or secondary (n = 14) AML were enrolled (58% male; median age, 60 years) in this study. The composite complete response with entospletinib + 7+3 was 70%. Patients with baseline HOXA9 and MEIS1 expression higher than the median had improved overall survival compared with patients with below median HOXA9 and MEIS1 expression. Common adverse events were cytopenias, febrile neutropenia, and infection. There were no dose-limiting toxicities. Entospletinib-related skin rash and hyperbilirubinemia were also observed.

Conclusions:

Entospletinib with intensive chemotherapy was well-tolerated in patients with AML. Improved survival was observed in patients with HOXA9/MEIS1 overexpression, contrasting published data demonstrating poor survival in such patients. A randomized study will be necessary to determine whether entospletinib was a mediator this observation.
Heavy Drinking Habits Are Associated with Worse In-Hospital Outcomes in Patients with Acute Coronary Syndrome: An Insight from the AMIS Plus Registry
Authors: Tersalvi Gregorio , Biasco Luigi , Radovanovic Dragana , Rickli Hans , Roffi Marco , Eberli Franz , Moccetti Marco , Jeger Raban , Moccetti Tiziano , Erne Paul , Pedrazzini Giovanni
Published: August 2020

Background: The association between alcohol consumption and the occurrence of coronary heart disease is well described in the literature, while data regarding the impact of regular alcohol consumption on in-hospital outcomes in the setting of acute coronary syndrome (ACS) are lacking. We aimed to evaluate the impact of self-reported alcohol consumption on in-hospital outcomes in patients with ACS. Methods: Data derived from patients enrolled between 2007 and 2019 in the Acute Myocardial Infarction in Switzerland (AMIS) Plus registry were retrospectively analyzed. Patients were stratified based on alcohol drinking pattern. Primary outcome was all-cause in-hospital mortality, while secondary outcomes were set as incidence of major adverse cardiac and cerebrovascular events (MACCEs). Outcome comparisons according to quantity of daily alcohol intake were also performed. Results: Records concerning alcohol consumption were available in 25,707 patients; 5,298 of them (21%) fulfilled the criteria of regular alcohol consumption. Regular drinkers were predominantly male, younger, smokers, more comorbid and with a worse clinical presentation as compared with abstainers/occasional drinkers. Daily alcohol intake was reported in 4,059 (77%) of these patients (regular drinkers). Among them, 2,640 were light drinkers (≤2 drinks/day) and 1,419 heavy drinkers (>2 drinks/day). In-hospital mortality and MACCEs of heavy drinkers were significantly higher compared with those of light drinkers (5.4 vs. 3.3% and 7.0 vs. 4.4%, both p = 0.001). When tested together with Global Registry of Acute Coronary Events risk score parameters, heavy alcohol consumption was independently associated with in-hospital mortality (p = 0.004). Conclusions: Our results support that heavy alcohol consumption is an independent predictor of in-hospital mortality in patients presenting with ACS.
Identification of Aneuploid Circulating Tumor Cells in Soft-Tissue Sarcoma Patients: A Pilot Study
Authors: Napolitano Andrea , Minelli Alessandro , Santini Daniele , Tonini Giuseppe , Vincenzi Bruno
Published: August 2020

Background: Circulating tumor cells (CTCs) have been identified and shown to have prognostic and predictive roles in several types of carcinoma. More recently, aneuploid CTCs have become subject of a growing interest, as aneuploidy is considered a hallmark of cancer often associated with poor prognosis. Here, we aimed to identify for the first time aneuploid CTCs in soft-tissue sarcoma (STS) patients and show supportive in silico evidence on the prognostic role of aneuploidy in mesenchymal cancers. Methods: In our pilot study, we collected blood from 4 metastatic STS patients and 4 age- and sex-matched healthy controls. After sample processing, cells were cyto-centrifuged onto glass slides and FISH was performed using 5 probes. The in silico analysis was performed using data from The Cancer Genome Atlas cohort of STS patients, using the validated Aneuploidy Score. We divided the patients in two populations (aneuploidy-high, Ane-Hi, and aneuploidy-low, Ane-Lo) using the median value of the Aneuploidy Score as a cutoff. Kaplan-Meier curves associated with log-rank test were used to compare progression-free and overall survival between groups. GraphPad Prism 8.0 (La Jolla, CA, USA) was used for statistical analyses. Results: Aneuploid CTCs were identified in all 4 STS patients and in none of the controls, with a median value of 4 (range 3–6) per 7 mL of blood. Ane-Hi patients showed a significantly worse progression-free and overall survival compared to Ane-Lo patients. The same trend was maintained when analyzing the data based on the different histologies. Conclusions: We identified for the first time aneuploid CTCs in STS patients using fluorescence in situ hybridization in a surface marker-independent way. We also showed that the Aneuploidy Score has a prognostic value both in terms of progression-free survival and overall survival in STS patients using The Cancer Genome Atlas data, regardless of the histology.
Acute Kidney Injury in Primary Care: A Review of Patient Follow-Up, Mortality, and Hospital Admissions following the Introduction of an AKI Alert System
Authors: Barton Anna L. , Williams Sam B.M. , Dickinson Stephen J. , Parry Rob G. , Pollard Adam
Published: August 2020

Background/Aims: In February 2017, our laboratory implemented an electronic AKI flagging system for primary care using the NHS England AKI detection algorithm. Our study investigated the impact on patient follow-up, hospital admission, length of stay, and mortality. Methods: Primary care results March 2017–February 2018 with an AKI test code were downloaded from the pathology computer. Results: Over 12 months, 1,784 AKI episodes were identified; 81.3% AKI1, 11.3%, AKI2, and 7.5% AKI3. A repeat creatinine was requested within 14 days on 55% AKI1s, 84% AKI2s, and 86% AKI3s. Primary care took the repeat sample in 73.2% AKI1s and 56.7% AKI2s and acute hospital locations for 47.4% AKI3s. Median time to hospital admission was 34 days for AKI1, 6 for AKI2, and 1 for AKI3 (p < 0.05). Length of stay was found to be 1, 2, and 4 days for AKI 1/2/3, respectively (p < 0.05). The 90-day mortality for admitted patients was 15, 18, and 21% for AKI 1/2/3, respectively (p = 0.180). The 90-day mortality for the non-admitted patients was 4, 9, and 50% for AKI 1/2/3, respectively (p < 0.05). AKI patient outcome data pre versus post the start of the AKI flag system were compared. A statistically significant reduction was found in the median length of stay for AKI1 and AKI3 and in mortality for AKI1 and AKI3 patients and for all AKIs as a whole. A further analysis was performed to take into account the difference in pre- and post-alert populations. Mortality overall was significantly improved (p < 0.001), and length of stay was reduced in AKI3 patients (p = 0.048). Discussion/Conclusion: Our study demonstrates that an electronic AKI warning alert system for primary care appears to be associated with a beneficial impact on patient management and outcome.
A Personalized Update on IgA Nephropathy: A New Vision and New Future Challenges
Authors: Gutiérrez Eduardo , Carvaca-Fontán Fernando , Luzardo Leonella , Morales Enrique , Alonso Marina , Praga Manuel
Published: August 2020

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world among patients undergoing renal biopsy. Approximately 30% of patients with IgAN develop end-stage kidney disease 20 years after renal biopsy. It is a glomerulopathy with a very broad clinical presentation, making it difficult to stratify and treat. IgAN is characterized by dysregulation of the immune system, which causes an abnormal synthesis of IgA1 that is deglycosylated causing its mesangial deposition. IgAN pathogenesis is incompletely understood; the current multi-hit hypothesis of IgAN pathogenesis does not explain the range of glomerular inflammation and renal injury associated with mesangial IgA deposition. Although associations between IgAN and glomerular and circulating markers of complement activation are established, the mechanism of complement activation and contribution to glomerular inflammation and injury are not defined. On the other hand, the renal-gut connection can also play an important role in the pathogenesis of IgAN with possible therapeutic implications. In order to standardize the histological findings, the Oxford Classification has allowed clarifying renal lesions that confer potential risk of progression. Currently, except for the blockade of the renin-angiotensin-aldosterone system, no other therapies are available in clinical setting for the treatment of IgAN, although the range of new drugs under investigation is extensive. The incorporation in the next trials of clinical parameters such as the amount of hematuria and histological lesions may allow more personalized therapeutic approaches. To summarize, in recent years, several important efforts have taken place in the understanding of IgAN, but still, further studies are warranted to elucidate the best therapeutic strategies according to the risk to improve the prognosis of this entity.