bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive Enhancers Associated with Decreased Risk of Injury in Patients with Dementia: A Nationwide Cohort Study in Taiwan
Authors: Chao Pei-Chun , Chien Wu-Chien , Chung Chi-Hsiang , Chu Ching-Wen , Yeh Chin-Bin , Huang San-Yuan , Lu Ru-Band , Chang Hsin-An , Kao Yu-Chen , Yeh Hui-Wen , Chiang Wei-Shan , Chou Yu-Ching , Tzeng Nian-Sheng
Published: November 2017

This study aimed to investigate the associations among dementia, psychotropic medications and the risk of overall injuries. In this nationwide matched cohort study, a total of 144 008 enrolled patients ≥age of 50, with 36 002 study subjects who suffered from dementia and 108 006 controls matched for sex and age, from the Inpatient Dataset, for the period 2000–2010 in Taiwan were selected from the National Health Insurance Research Database, according to International Classification of Diseases, 9th Revision, Clinical Modification. When adjusting for the confounding factors, a Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 10 years of follow-up. Of the study subjects, 6701 (18.61%) suffered injury when compared with 20 919 (19.37%) in the control group. The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 2.294, 95% CI=2.229 to 2.361, P<0.001) after adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the subjects with dementia were associated with the risk of injury (adjusted HR=0.217, 95% CI: 0.206 to 0.228, P<0.001). Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, were associated with the risk of injury in the study subjects after being adjusted for all comorbidities and medications (adjusted HR=0.712(95% CI=0.512 to 0.925, P<0.01)). In conclusion, patients who suffered dementia had a higher risk of developing injury, and the cognitive enhancers were associated with the decreased risk of injury.
Mir-23A Acts as An Oncogene in Pancreatic Carcinoma by Targeting Foxp2
Authors: Diao Hongliang , Ye Zhou , Qin Renyi
Published: November 2017

MicroRNAs have been reported to play an important role in tumor development and progression by targeting oncogenes and tumor suppressors. miR-23a has been described as significantly upregulated in multiple cancers and involved in tumorigenesis. The aim of this study was to evaluate the potential roles of miR-23a in pancreatic ductal adenocarcinoma (PDAC). We found that miR-23a level was significantly increased in tissues of PDAC compared with that in the control by real-time PCR. FOXP2 expression was downregulated and inversely correlated with miR-23a. miR-23a directly targeted the 3’-untranslated region of FOXP2 mRNA and repressed its expression. Mechanistically, enhancement of miR-23a by transfection with mimics in Aspc-1 cells significantly promoted cell proliferation and invasion, while miR-23a inhibitors transfection in SW1990 cells induced an inhibitory effect. Moreover, restoration of FOXP2 impaired the pro-proliferation and proinvasion effects of miR-23a, indicating FOXP2 is a direct mediator of miR-23a functions. In conclusion, our findings suggest a novel miR-23a/FOXP2 link contributing to PDAC development and invasion. It may be a potential diagnostic and therapeutic target for PDAC.
Forecasting the response of Great Lakes sea lamprey (Petromyzon marinus) to barrier removals
Authors: Jensen Alexander J. , Jones Michael L.
Published: November 2017

A key uncertainty surrounding barrier removals in the Great Lakes is the response of invasive sea lamprey (Petromyzon marinus) populations to realized increases in available habitat for adfluvial species. We addressed this uncertainty by applying a management strategy evaluation model, originally developed to inform sea lamprey management in the Great Lakes, to forecast the effects of barrier removal on Lake Michigan sea lamprey abundances. We used this model to characterize the response to systematically increasing habitat availability and a specific proposed barrier removal. Our results suggest the removals allow novel production from newly opened habitat and, assuming a fixed budget for sea lamprey control, decrease the overall effectiveness of control, leading to disproportionate increases in abundance. The case study demonstrated that evaluating population effects only at the scale of watersheds directly affected by barrier removals would substantially underestimate effects at the scale of Lake Michigan. Similar population responses are possible when evaluating the effects on desired species. Our findings highlight the importance of considering trade-offs for barrier removals and selecting the appropriate scale for forecasting.
Tune-out wavelengths for helium-like ions in plasma environments
Authors: Kar Sabyasachi , Wang Yu-Shu , Wang Yang , Ho Yew Kam
Published: November 2017

We investigate the influence of model plasma environments on the tune-out wavelengths for helium-like ions based on the Debye–Hückel shielding approach to plasma modeling. The dynamic polarizability for the lowest singlet and triplet S-states of the helium-like ions (Z = 3–8) for various screening parameters are calculated using correlated exponential wave functions within the framework of pseudostates summation method. Frequency-dependent polarizability for the 2 3S state; energies for the 1 1S → 2 1P and 2 3S → 2 3P transitions; tune-out wavelengths for the 1 1S and 2 3S states as functions of screening parameter, are reported. For the unscreened cases, our results are in agreement with the available theoretical and experimental predictions.
Cotorsion Pairs in 𝒞N(A)
Authors: Yang Xiaoyan , Cao Tianya
Published: November 2017

Given a cotorsion pair ([Formula: see text], [Formula: see text]) in an abelian category [Formula: see text] , we define cotorsion pairs ([Formula: see text], dg[Formula: see text]) and (dg[Formula: see text], [Formula: see text]) in the category [Formula: see text]N([Formula: see text]) of N-complexes on [Formula: see text]. We prove that if the cotorsion pair ([Formula: see text], [Formula: see text]) is complete and hereditary in a bicomplete abelian category, then both of the induced cotorsion pairs are complete, compatible and hereditary. We also create complete cotorsion pairs (dw[Formula: see text], (dw[Formula: see text])⊥), (ex[Formula: see text], (ex[Formula: see text])⊥) and (⊥(dw[Formula: see text]), dw[Formula: see text]), (⊥(ex[Formula: see text]); ex[Formula: see text]) in a termwise manner by starting with a cotorsion pair ([Formula: see text], [Formula: see text]) that is cogenerated by a set. As applications of these results, we obtain more abelian model structures from the cotorsion pairs.
On Generalization of Cycles and Chordality to Clutters from an Algebraic Viewpoint
Authors: Nikseresht Ashkan , Zaare-Nahandi Rashid
Published: November 2017

In this paper, we study the notion of chordality and cycles in clutters from a commutative algebraic point of view. The corresponding concept of chordality in commutative algebra is having a linear resolution. We mainly consider the generalization of chordality proposed by Bigdeli et al. in 2017 and the concept of cycles introduced by Cannon and Faridi in 2013, and study their interrelations and algebraic interpretations. In particular, we investigate the relationship between chordality and having linear quotients in some classes of clutters. Also, we show that if [Formula: see text] is a clutter such that 〈[Formula: see text]〉 is a vertex decomposable simplicial complex or I([Formula: see text]) is squarefree stable, then [Formula: see text] is chordal.
Local Superderivations on Basic Classical Lie Superalgebras
Authors: Chen Haixian , Wang Ying , Nan Jizhu
Published: November 2017

In this paper, we prove that every local superderivation on basic classical Lie superalgebras except for A(1, 1) over the complex number field ℂ is a superderivation. Furthermore, we give an example of a class of nilpotent Lie superalgebras with local superderivations which are not superderivations.
Irreducible Weight Modules with a Finite-Dimensional Weight Space over the Twisted N = 1 Schrödinger-Neveu-Schwarz Algebra
Authors: Fa Huanxia , Han Jianzhi , Li Junbo
Published: November 2017

It is shown that there are no simple mixed modules over the twisted N = 1 Schrödinger-Neveu-Schwarz algebra, which implies that every irreducible weight module over it with a non-trivial finite-dimensional weight space is a Harish-Chandra module.
Construction of Ventilation Corridors and Smog Control in Beijing
Authors: DU Wupeng , ZHU Rong , FANG Xiaoyi
Published: November 2017

Ventilation corridors are designed to relieve heat island effect, enhance ventilation and protect the land used for climatic and environmental enhancement in a city. Observations and analogs of ventilation corridors in typical regions show that ventilation corridors affect micro-climatic environment to a certain extent and help to reduce local heat island effect and increase local wind speed; but they contribute little to wind speed in a static or nearly static condition. Influenced by climate change and urbanization, China has been frequently blighted by large-scale smog in recent years. However, ventilation corridors cannot change the meteorological condition of large-scale air stagnation and other conditions against air diffusion. The best solution to air pollution is the emission control of pollution sources. Rational planning and construction of ventilation corridors, in the meantime, can be a supplementary measure for urban ecological and environmental improvement in a long run.
Textural changes of graphitic carbon by tectonic and hydrothermal processes in an active plate boundary fault zone, Alpine Fault, New Zealand
Authors: Kirilova Martina , Toy Virginia G. , Timms Nick , Halfpenny Angela , Menzies Catriona , Craw Dave , Beyssac Olivier , Sutherland Rupert , Townend John , Boulton Carolyn , Carpenter Brett M. , Cooper Alan , Grieve Jason , Little Timothy , Morales Luiz , Morgan Chance , Mori Hiroshi , Sauer Katrina M. , Schleicher Anja M. , Williams Jack , Craw Lisa
Published: November 2017

Graphitization in fault zones is associated both with fault weakening and orogenic gold mineralization. We examine processes of graphitic carbon emplacement and deformation in the active Alpine Fault Zone, New Zealand by analysing samples obtained from Deep Fault Drilling Project (DFDP) boreholes. Optical and scanning electron microscopy reveal a microtextural record of graphite mobilization as a function of temperature and ductile then brittle shear strain. Raman spectroscopy allowed interpretation of the degree of graphite crystallinity, which reflects both thermal and mechanical processes. In the amphibolite-facies Alpine Schist, highly crystalline graphite, indicating peak metamorphic temperatures up to 640°C, occurs mainly on grain boundaries within quartzo-feldspathic domains. The subsequent mylonitization process resulted in the reworking of graphite under lower temperature conditions (500–600°C), resulting in clustered (in protomylonites) and foliation-aligned graphite (in mylonites). In cataclasites, derived from the mylonitized schists, graphite is most abundant (<50% as opposed to <10% elsewhere), and has two different habits: inherited mylonitic graphite and less mature patches of potentially hydrothermal graphitic carbon. Tectonic–hydrothermal fluid flow was probably important in graphite deposition throughout the examined rock sequences. The increasing abundance of graphite towards the fault zone core may be a significant source of strain localization, allowing fault weakening.
Detection of Emerging Zoonotic Pathogens: An Integrated One Health Approach
Authors: Bird Brian H. , Mazet Jonna A.K.
Published: November 2017

The emergence of novel zoonotic pathogens is one of the greatest challenges to global health security. The advent of increasingly sophisticated diagnostics tools has revolutionized our capacity to detect and respond to these health threats more rapidly than ever before. Yet, no matter how sophisticated these tools become, the initial identification of emerging infectious diseases begins at the local community level. It is here that the initial human or animal case resides, and it is here that early pathogen detection would have maximum benefit. Unfortunately, many areas at highest risk of zoonotic disease emergence lack sufficient infrastructure capacity to support robust laboratory diagnostic systems. Multiple factors are essential for pathogen detection networks, including an understanding of the complex sociological and ecological factors influencing disease transmission risk, community engagement, surveillance along high-risk human-animal interfaces, and a skilled laboratory workforce. Here we discuss factors relevant to the emerging disease paradigm, recent technical advances in diagnostic methods, and strategies for comprehensive and sustainable approaches to rapid zoonotic disease detection.
Cross-organ sensitization between the colon and bladder: to pee or not to pee?
Authors: Grundy Luke , Brierley Stuart M.
Published: November 2017

Chronic abdominal and pelvic pain are common debilitating clinical conditions experienced by millions of patients around the globe. The origin of such pain commonly arises from the intestine and bladder, which share common primary roles (the collection, storage, and expulsion of waste). These visceral organs are located in close proximity to one another and also share common innervation from spinal afferent pathways. Chronic abdominal pain, constipation, or diarrhea are primary symptoms for patients with irritable bowel syndrome or inflammatory bowel disease. Chronic pelvic pain and urinary urgency and frequency are primary symptoms experienced by patients with lower urinary tract disorders such as interstitial cystitis/painful bladder syndrome. It is becoming clear that these symptoms and clinical entities do not occur in isolation, with considerable overlap in symptom profiles across patient cohorts. Here we review recent clinical and experimental evidence documenting the existence of “cross-organ sensitization” between the colon and bladder. In such circumstances, colonic inflammation may result in profound changes to the sensory pathways innervating the bladder, resulting in severe bladder dysfunction.
Specific force of the vastus lateralis in adults with achondroplasia
Authors: Sims David T. , Onambélé-Pearson Gladys L. , Burden Adrian , Payton Carl , Morse Christopher I.
Published: November 2017

Achondroplasia is a clinical condition defined by shorter stature and disproportionate limb length. Force production in able-bodied individuals (controls) is proportional to muscle size, but given the disproportionate nature of achondroplasia, normalizing to anatomical cross-sectional area (ACSA) is inappropriate. The aim of this study was to assess specific force of the vastus lateralis (VL) in 10 adults with achondroplasia (22 ± 3 yr) and 18 sex-matched controls (22 ± 2 yr). Isometric torque (iMVCτ) of the dominant knee extensors (KE) and in vivo measures of VL muscle architecture, volume, activation, and patella tendon moment arm were used to calculate VL physiological CSA (PCSA), fascicle force, and specific force in both groups. Achondroplasic muscle volume was 53% smaller than controls (284 ± 36 vs. 604 ± 102 cm3, P < 0.001). KE iMVCτ was 63% lower in achondroplasia compared with controls (95 ± 24 vs. 256 ± 47 N⋅m, P < 0.001). Activation and moment arm length were similar between groups ( P > 0.05), but coactivation of bicep femoris of achondroplasic subjects was 70% more than controls (43 ± 20 vs. 13 ± 5%, P < 0.001). Achondroplasic subjects had 58% less PCSA (43 ± 10 vs. 74.7 ± 14 cm2, P < 0.001), 29% lower fascicle force (702 ± 235 vs. 1704 ± 303 N, P < 0.001), and 29% lower specific force than control subjects (17 ± 6 vs. 24 ± 6 N⋅cm−2, P = 0.012). The smaller VL specific force in achondroplasia may be attributed to infiltration of fat and connective tissue, rather than to any difference in myofilament function.

NEW & NOTEWORTHY The novel observation of this study was the measurement of normalized force production in a group of individuals with disproportionate limb length-to-torso ratios.
Overweight and Normal-Weight Children’s Decision-Making in a Child Variant of the Iowa Gambling Task
Authors: Lensing Nele , Elsner Birgit
Published: November 2017

In the Iowa Gambling Task (IGT), overweight as compared to normal-weight adults make more risky decisions resulting in immediate rewards and long-term losses. Findings regarding a potentially moderating role of gender have been inconsistent and investigations on the development of weight-group differences in decision-making during childhood are lacking. Using a 3-wave longitudinal study, we examined decision-making in a matched sample of 94 overweight and 94 normal-weight children (49% girls, aged 6–9 years at wave 1) over a 3-year period. Decision-making was measured with the Hungry Donkey Task (HDT), an age-appropriate version of the IGT, and learning within the task was examined via analysis across trial blocks. Mixed-design ANOVA revealed that more risky decisions were made by overweight as compared to normal-weight children and by girls as compared to boys. Within-task learning was evident at all three waves, moderated by weight group and gender. However, although risky decisions generally decreased across the 3-year period, weight-group and gender differences did not significantly change over the 3-year period. Our findings demonstrate that weight-group and gender differences in decision-making are already present and do not significantly change over a 3-year period in middle childhood.
Abdominal Manual Therapy Repairs Interstitial Cells of Cajal and Increases Colonic c-Kit Expression When Treating Bowel Dysfunction after Spinal Cord Injury
Authors: Zhu Yi , Yang Yujie , Guo Jiabao , Zhang Wenyi , Zhu Zhaojin , Xie Bin , Yu Jun , Cheng Jie
Published: November 2017

Background. This study aimed to evaluate the therapeutic effects of abdominal manual therapy (AMT) on bowel dysfunction after spinal cord injury (SCI), investigating interstitial cells of Cajal (ICCs) and related c-kit expression. Methods. Model rats were divided as SCI and SCI with drug treatment (intragastric mosapride), low-intensity (SCI + LMT; 50 g, 50 times/min), and high-intensity AMT (SCI + HMT; 100 g, 150 times/min). After 14 days of treatment, weight, improved Basso-Beattie-Bresnahan (BBB) locomotor score, and intestinal movement were evaluated. Morphological structure of spinal cord and colon tissues were examined. Immunostaining, RT-PCR, and western blot were used to assess c-kit expression. Results. In SCI rats, AMT could not restore BBB, but it significantly increased weight, shortened time to defecation, increased feces amounts, and improved fecal pellet traits and colon histology. AMT improved the number, distribution, and ultrastructure of colonic ICCs, increasing colonic c-kit mRNA and protein levels. Compared with the SCI + Drug and SCI + LMT groups, the SCI + HMT group showed better therapeutic effect in improving intestinal transmission function and promoting c-kit expression. Conclusions. AMT is an effective therapy for recovery of intestinal transmission function. It could repair ICCs and increase c-kit expression in colon tissues after SCI, in a frequency-dependent and pressure-dependent manner.
Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
Authors: Buha Aleksandra , Wallace David , Matovic Vesna , Schweitzer Amie , Oluic Branislav , Micic Dusan , Djordjevic Vladimir
Published: November 2017

Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant. Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC. Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizing the evidence of Cd involvement in PC development and describing the possible mechanisms. Consolidation of epidemiological data on PC and exposure to Cd indicated a significant association with an elevated risk of PC among general population exposed to Cd. Cadmium exposure of laboratory animals was showed to cause PC supporting the findings suggested by human studies. The concordance with human and animal studies is buttressed by in vitro studies, although in vitro data interpretation is problematic. In most instances, only significant effects are reported, and the concentrations of Cd are excessive, which would skew interpretation. Previous reports suggest that oxidative stress, apoptotic changes, and DNA cross-linking and hypermethylation are involved in Cd-mediated carcinogenesis. Undoubtedly, a significant amount of work is still needed to achieve a better understanding of the Cd involvement in pancreatic cancer which could facilitate prevention, diagnosis, and therapy of this fatal disease.
Study on the Clinical Safe and Effective Methods of Arsenic‐Containing Compound‐Qinghuang Powder in the Treatment of Myelodysplastic Syndrome
Authors: Zhu Qianzhe , Deng Zhongyang , Zhu Shirong , Zhao Pan , Wang Mingjing , Hu Xiaomei
Published: November 2017

Objective. To establish the clinical safe and effective methods of arsenic‐containing compound‐Qinghuang Powder (compound‐QHP) in the treatment of myelodysplastic syndrome (MDS). Methods. 200 patients with MDS were treated with compound‐QHP (daily dose of 0.1 g realgar). The blood arsenic concentrations (BACs) were detected by atomic fluorescence spectrophotometry (HF‐AFS). After treatment for 1 month, the patients were randomly divided into group A and group B when the BACs were less than 20 μg/L. Daily dose of realgar was maintained in group A and it was increased to that when the BACs were more than 20 μg/L in group B. The BAC and clinical efficacy and safety in two groups were compared at the end of the treatment with compound‐QHP. Results. The average BAC of group B was significantly higher than that of group A (P < 0.01). The rates of hematology improvement and reduced transfusion were significantly higher in group B than in group A (P < 0.05). The HGB, ANC, and PLT significantly increased in group B after treatment (P > 0.05). Conclusions. Monitoring the BAC and adjusting the daily dose of realgar to increase the effective BAC and then improving efficacy without increasing the clinical toxicity are the clinical safe and effective methods in the treatment of MDS.
Restrictive Transfusion Strategy Does Not Affect Clinical Prognosis in Patients with Ectopic Pregnancy
Authors: Huang Yanjuan , Liang Yi , Ma He , Ling Mei , Ran Xuelian , Huang Jingxian , Lu Kejian , Zhong Risheng , Huang Fanke , Bin Wenwu
Published: November 2017

To assess the effects of restrictive transfusion strategy on hemoglobin (Hb) levels and prognosis in patients with ectopic pregnancy and severe hemorrhage undergoing emergency surgery, patient data were collected from 2012 to 2016. Following transfusion guidelines, restrictive transfusion was performed; at Hb levels of 60–70 to 100 g/L, transfusion was continued or not based on disease status. The patients were divided into four groups: blood loss < 400 ml (N1), 400–799 ml (N2), 800–1199 ml (N3), and ≥1200 ml (N4). Several prognosis parameters were assessed. GroupN4 was further divided based on blood loss amounts (1200–1999, 2000–2999, 3000–3999, and 4000–5000 ml) for subgroup analyses. Blood loss, hemoglobin levels at discharge, and American Society of Anesthesiologists (ASA) scores were not associated with patient prognostic parameters, including intensive care unit (ICU) occupancy, cure, and healing rates, and surgical complications and hospital stay. No statistically significant difference was obtained in hospital stay amongN1,N2, andN3 groups. Compared withN1 patients, cases with blood loss ≥ 1200 ml had significantly longer hospital stay. Interestingly, hospital stay was correlated with surgical approach, location of pregnancy, and operation time. Restrictive transfusion strategy could be safely used for emergency surgery in ectopic pregnancy with acute blood loss.
Group A Streptococci-Associated Necrotizing Fasciitis following Cat Bite in an Immunocompromised Patient
Authors: Nambiar Sudheer , Karippot Asha , Devasahayam Joe , Oliver Tony
Published: November 2017

Necrotizing soft tissue infections are characterized clinically by fulminant tissue destruction, systemic signs of toxicity, and high mortality. Accurate diagnosis and appropriate treatment must include early surgical intervention and antibiotic therapy. Mortality rate is very high and could be even higher in an immunocompromised host. We present a 57-year-old female with history of rheumatoid arthritis on oral corticosteroid and methotrexate therapy with painful swelling of the left hand following a cat bite that was diagnosed as having group A streptococcus pyogenes-associated necrotizing fasciitis. Treatment with ampicillin-sulbactam, Clindamycin, and surgical debridement was performed. In spite of all the adequate therapy she succumbed to death from streptococcal toxic shock and related complications after thirty-two days of treatment in intensive care unit. Necrotizing fasciitis is an uncommon but life-threatening complication in immunocompromised hosts. Tissue infections in cat bite wounds are commonly caused by pathogenic bacterium known as Pasteurella multocida. Group A streptococcal infections are not reported following cat bites. A high index of suspicion must be maintained to suspect group A streptococcal associated necrotizing fasciitis following cat bites and an early medical and surgical intervention should be made for any best possible outcome.
Continuous Synthesis of Ag/TiO2 Nanoparticles with Enhanced Photocatalytic Activity by Pulsed Laser Ablation
Authors: Zhou Rui , Lin Shengdong , Zong Huixin , Huang Tingting , Li Fengping , Pan Jiahong , Cui Jingqin
Published: November 2017

A facile and environmental friendly synthesis strategy based on pulsed laser ablation has been developed for potential mass production of Ag-loaded TiO2 (Ag/TiO2) nanoparticles. By sequentially irradiating titanium and silver target substrates, respectively, with the same 1064 nm 100 ns fiber laser, Ag/TiO2 particles can be fabricated. A postannealing process leads to the crystallization of TiO2 to anatase phase with high photocatalytic activity. The phase composition, microstructure, and surface state of the elaborated Ag/TiO2 are characterized by X-ray diffraction (XRD), energy dispersive X-ray (EDX), field emission scanning electron microscope (FESEM), transmission electron microscope (TEM), and X-ray photoelectron spectroscopy (XPS) techniques. The results suggest that the presence of silver clusters deposited on the surface of TiO2 nanoparticles. The nanostructure is formed through laser interaction with materials. Photocatalytic activity evaluation shows that silver clusters could significantly enhance the photocatalytic activity of TiO2 in degradation of methylene blue (MB) under UV light irradiation, which is attributed to the efficient electron traps by Ag clusters. Our developed Ag/TiO2 nanoparticles synthesized via a straightforward, continuous, and green pathway could have great potential applications in photocatalysis.
The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis
Authors: Tang Liang , Wang Yan , Chen Yiwei , Chen Lianghui , Zheng Shui , Bao Meihua , Xiang Ju , Luo Huaiqing , Li Jianming , Li Yungui
Published: November 2017

The serotonin receptor gene (5-HT2A) has been reported to be a susceptible factor in behavioral and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD). However, previous results were conflicting. We aim to investigate the association of 5-HT2A T102C with BPSD in AD using a meta-analysis. Studies were collected using PubMed, Web of Science, the Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), and Embase. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess associations. Nine studies with 1899 AD patients with/without BPSD were included in this meta-analysis. The 102C and CC genotypes were associated with psychosis in AD (102C: p<0.00001, OR [95% CI] = 3.19 [2.12–4.79]; CC: p<0.00001, OR [95% CI] = 7.24 [3.60–14.59]). The TT genotype was significantly associated with hallucinations, aberrant motor behavior, and psychosis in AD (hallucinations: p=0.001, OR [95% CI] = 0.52 [0.36–0.77]; aberrant motor behavior: p=0.03, OR [95% CI] = 0.58 [0.35–0.95]; and psychosis: p=0.002, OR [95% CI] = 0.34 [0.17–0.67]). No association was observed between T102C alleles or genotypes and delusions, agitation/aggression, depression, and apathy (p>0.05). Thus, the 5HT2A T102C might be a susceptible factor for hallucinations, aberrant motor behavior, and psychosis in AD. The potential mechanism of this polymorphism in BPSD in AD requires further exploration.
Common Fixed Point and Coupled Coincidence Point Theorems for Geraghty’s Type Contraction Mapping with Two Metrics Endowed with a Directed Graph
Authors: Charoensawan P. , Atiponrat W.
Published: November 2017

The purpose of this paper is to present some existence and uniqueness results for common fixed point theorems for θ-ϕ contraction mappings with two metrics endowed with a directed graph. In addition, by using our main results, we obtain some results about coupled coincidence points endowed with a directed graph. Our results generalize those presented in previous papers.
The Power of Place: A Case Study of Auckland’s Design Creative Industries
Authors: Kiroff Lydia
Published: November 2017

Auckland is New Zealand’s largest city which also has the largest concentration of creative sector employment and businesses in the country. This study examines the spatial logic of firms in the design creative subsector in inner Auckland to gain better understanding of the ways in which place, space, and built form determine location choices. Firms’ attributes are also analysed with the aim of ascertaining whether firms with shared characteristics have similar spatial behaviour. Despite a high degree of spatial clustering, the unequal distribution of firms across inner Auckland suggests that some areas, such as Parnell, are favoured more than others. Parnell’s unique heritage built environment was identified as a location factor that has appealed to architects, designers, and advertisers and has contributed to the formation of the area’s creative clusters. The quality of Parnell’s built environment was associated with place reputation and image branding which was an important part of creating firm’s identity. A central location and the attractiveness of an amenities-rich local environment also played a role in the decision-making process. Furthermore, the results also suggest that firms that possess common characteristics have similar spatial logic and make similar location choices.
On the Use of the Analogue Transformation Acoustics in Aeroacoustics
Authors: Iemma Umberto , Palma Giorgio
Published: November 2017

The objective of the paper is the assessment of the Analogue Transformation Acoustics (ATA) in the design of acoustic metamaterial for aeronautical applications. The work focuses on the consistency of the background flow resulting from the application of the ATA with the equations governing the potential aerodynamics. Indeed, in case of acoustic perturbations propagating within moving media, the convective terms in the governing equations are responsible for the failure of formal invariance under the action of conformal mappings. The ATA approach overcomes this limitation, introducing the possibility of handling the convective form of the wave equation in a straightforward and elegant way. It is based on the concept of analogue space‐time and fully relies on the analytical tools of Lorentzian differential geometry. The present paper analyses the relationship between the analogue velocity field with a realistic potential flow. The method is validated through numerical simulations using two widely assessed acoustic cloaking problems. The preliminary results obtained show that the use of numerical, quasi‐conformal mappings can lead to transformed streamlines negligibly deviating from those of the potential velocity field satisfying the fluid‐dynamic conservation laws, but with incompatible intensity of the local velocity.
Improvement of Corona Discharge Model and Its Application on Simulating Corona Discharge in the Presence of Wind
Authors: Guo Xiufeng , Zhang Qilin , Zhang Jinbo
Published: November 2017

To evaluate the effect of wind on corona discharges occurring on the tip of a grounded rod during a negative charging process of thundercloud, a two‐dimensional numerical model has been improved by considering the wind velocity as a driving force for the movement of the corona charges. It was found that not only wind speed but also wind direction have a significant effect on the distribution of corona charges, the local electric field around the rod, and the corona current. (1) Under the same wind speed, a larger horizontal wind can result in less accumulation of corona charges, a larger electric field, and a larger corona current. However, when the speed is less than 5 m s−1, the effect of wind direction on the corona current was weak. (2) Under the same wind direction, a larger wind speed can cause a larger corona current. However, when the horizontal wind component is smaller than the vertical, the larger wind speed would cause a smaller electric field. Thus, it is necessary to take the effects of the wind direction into consideration, rather than to consider its speed only, when studying the corona discharge and its effects on the upward leader.
Pulmonary Arteriovenous Malformation as a Cause of Embolic Stroke: Case Report and Review of the Literature
Authors: Anticoli Sabrina , Pezzella Francesca Romana , Siniscalchi Antonio , Gallelli Luca , Bravi Maria Cristina
Published: November 2017

Background: Pulmonary arteriovenous malformation (PAVM) is an abnormal communication between pulmonary arteries and veins responsible for right-to-left shunting that could induce the development of embolic stroke. Summary: We describe an 82-year-old woman without history of respiratory or neurological diseases, who presented at our observation unit with acute onset of cerebral ischemia. Clinical, laboratory and radiological findings diagnosed a PAVM. Key Messages: Usually, endovascular procedures based on embolization or, alternatively, surgery represent the recommended treatment. However, both hormonal therapy and thrombolytic therapy can be used. In our patient, treatment with warfarin induced a remission of symptoms. This strategy should be tested in larger studies. i 2014 S. Karger AG, Basel
Comparison of Efficacy and Safety of Liraglutide 3.0 mg in Individuals with BMI above and below 35 kg/m²: A Post-hoc Analysis
Authors: le Roux Carel , Aroda Vanita , Hemmingsson Joanna , Cancino Ana Paula , Christensen Rune , Pi-Sunyer Xavier
Published: November 2017

Objective: To investigate whether the efficacy and safety of liraglutide 3.0 mg differed between two subgroups, BMI 27 to <35 and BMI ≥ 35 kg/m², in individuals without and with type 2 diabetes (T2D). Methods: A post-hoc analysis of two 56-week, randomized, double-blind, placebo-controlled trials (SCALE Obesity and Prediabetes; SCALE Diabetes). Subgroup differences in treatment effects of liraglutide 3.0 mg were evaluated by testing the interaction between treatment group and baseline BMI subgroup. Results: Significantly greater weight loss (0-56 weeks) was observed with liraglutide 3.0 mg versus placebo in all patient groups while on treatment. There was no evidence that the weight-lowering effect of liraglutide 3.0 mg differed between BMI subgroups (interaction p > 0.05). Similarly, for most secondary endpoints significantly greater improvements were observed with liraglutide 3.0 mg versus placebo, with no indication treatment effects differing between subgroups. The safety profile of liraglutide 3.0 mg was broadly similar across BMI subgroups. Conclusion: This post-hoc analysis did not indicate any differences in the treatment effects, or safety profile, of liraglutide 3.0 mg for individuals with BMI 27 to <35 or ≥35 kg/m². Liraglutide 3.0 mg can therefore be considered for individuals with a BMI of ≥35 as well as for those with a BMI of 27 to <35 kg/m².
Lichen Planus Pemphigoides Induced by Enalapril: A Case Report and a Review of Literature
Authors: Onprasert Woranit , Chanprapaph Kumutnart
Published: November 2017

Lichen planus pemphigoides (LPP) is a rare autoimmune bullous dermatosis. The clinical presentation of LPP may mimic bullous pemphigoid making the diagnosis difficult. A thorough clinical, histopathological, and immunological evaluation is essential for the diagnosis of LPP. The etiology is largely idiopathic; however, there are several case reports of drug-induced LPP. We report an 81-year-old Thai woman with underlying hypertension and type 2 diabetes mellitus who presented with a 4-week history of multiple tense bullae initially on the hands and feet that subsequently expanded to the trunk and face. Enalapril was commenced to control hypertension. The histopathology and direct immunofluorescence were compatible with LPP. Circulating anti-basement antibodies BP180 was also positive. The patient was treated with topical corticosteroid with a modest effect. Enalapril was discontinued and complete resolution of LPP occurred within 12 weeks. There was no recurrence after a 1-year follow-up period. To the best of our knowledge, we present the first case of enalapril-induced LPP. Early recognition and prompt discontinuation of the culprit drug allow resolution of the disease. Medication given for LPP alone, without cessation of the offending drug, may not change the course of this condition.
Antimicrobial Activity of Galangin and Its Effects on Murein Hydrolases of Vancomycin-Intermediate Staphylococcus aureus (VISA) Strain Mu50
Authors: Ouyang Jing , Sun Fengjun , Feng Wei , Xie Yonghong , Ren Lijuan , Chen Yongchuan
Published: November 2017

Backgroud: Antibiotic treatment for infections caused by vancomycin-intermediate Staphylococcus aureus (VISA) strains is challenging, and only a few effective and curative methods have been developed to combat these strains. This study aimed to investigate the antimicrobial activity of galangin against S. aureus and its effects on the murein hydrolases of VISA strain Mu50. This is the first report on these effects of galangin, and it may help to improve the treatment for VISA infections by demonstrating the effective use of galangin. Methods: Firstly, the minimum inhibitory concentration (MIC) and growth curve were used to investigate the antimicrobial activity of galangin against S. aureus. Secondly, transmission electron microscopy (TEM) was used to observe morphological changes of VISA strain Mu50. Thirdly, Triton X-100-induced autolysis and cell wall hydrolysis assays were performed to determine the activities of the murein hydrolases of Mu50. Finally, fluorescence real-time quantitative PCR was used to investigate the expression of the murein hydrolase-related Mu50 genes. Results: The results indicated that the MIC of galangin was 32 μg/mL against ATCC25293, N315, and Mu50, and galangin could significantly suppress the bacterial growth (p < 0.05) with concentrations of 4, 8 and 16 μg/mL, compared with control group (0 μg/mL). To explore the possible reasons of bacteriostatic effects of galangin, we observed morphological changes using TEM which showed that the division of Mu50 daughter cells treated with galangin was obviously inhibited. Considering the vital role of murein hydrolases in cellular division, assays were performed, and galangin markedly decreased Triton X-100-induced autolysis and cell wall hydrolysis. Galangin also significantly inhibited the expression of the murein hydrolase genes (atl, lytM, and lytN) and their regulatory genes (cidR, cidA, and cidB). Conclusions: Our findings indicated that galangin can effectively inhibit murein hydrolase activity as well as the growth of VISA strain Mu50.
Improved Scalability of Neuron-Based Phenotypic Screening Assays for Therapeutic Discovery in Neuropsychiatric Disorders
Authors: Spicer Timothy P. , Hubbs Christopher , Vaissiere Thomas , Collia Deanna , Rojas Camilo , Kilinc Murat , Vick Kyle , Madoux Franck , Baillargeon Pierre , Shumate Justin , Martemyanov Kirill A. , Page Damon T. , Puthanveettil Sathya , Hodder Peter , Davis Ronald , Miller Courtney A. , Scampavia Louis , Rumbaugh Gavin
Published: November 2017

There is a pressing need to improve approaches for drug discovery related to neuropsychiatric disorders (NSDs). Therapeutic discovery in neuropsychiatric disorders would benefit from screening assays that can measure changes in complex phenotypes linked to disease mechanisms. However, traditional assays that track complex neuronal phenotypes, such as neuronal connectivity, exhibit poor scalability and are not compatible with high-throughput screening (HTS) procedures. Therefore, we created a neuronal phenotypic assay platform that focused on improving the scalability and affordability of neuron-based assays capable of tracking disease-relevant phenotypes. First, using inexpensive laboratory-level automation, we industrialized primary neuronal culture production, which enabled the creation of scalable assays within functioning neural networks. We then developed a panel of phenotypic assays based on culturing of primary neurons from genetically modified mice expressing HTS-compatible reporters that capture disease-relevant phenotypes. We demonstrated that a library of 1,280 compounds was quickly screened against both assays using only a few litters of mice in a typical academic laboratory setting. Finally, we implemented one assay in a fully automated high-throughput academic screening facility, illustrating the scalability of assays designed using this platform. These methodological improvements simplify the creation of highly scalable neuron-based phenotypic assays designed to improve drug discovery in CNS disorders.
Dietary Fructo-Oligosaccharides Attenuate Early Activation of CD4+ T Cells Which Produce both Th1 and Th2 Cytokines in the Intestinal Lymphoid Tissues of a Murine Food Allergy Model
Authors: Tsuda Masato , Arakawa Haruka , Ishii Narumi , Ubukata Chihiro , Michimori Mana , Noda Masanari , Takahashi Kyoko , Kaminogawa Shuichi , Hosono Akira
Published: November 2017

Background: Fructo-oligosaccharides (FOS) are prebiotic agents with immunomodulatory effects involving improvement of the intestinal microbiota and metabolome. In this study, we investigated the cellular mechanisms through which FOS modulate intestinal antigen-specific CD4+ T cell responses in food allergy, using OVA23-3 mice. Methods: OVA23-3 mice were fed an experimental diet containing either ovalbumin (OVA) or OVA and FOS for 1 week. Body weight and mucosal mast cell protease 1 in the serum were measured as the indicator of intestinal inflammation. Single-cell suspensions were prepared from intestinal and systemic lymphoid tissues for cellular analysis. Cytokine production was measured by ELISA. Activation markers and intracellular cytokines in CD4+ T cells were analyzed by flow cytometry. Activated CD4+ T cells were purified to examine cytokine production. Results: Dietary intake of FOS provided moderate protection from the intestinal inflammation induced by the OVA-containing diet. FOS significantly reduced food allergy-induced Th2 cytokine responses in intestinal tissues but not in systemic tissues. FOS decreased OVA diet-induced IFN-γ+IL-4+ double-positive CD4+ T cells and early-activated CD45RBhighCD69+CD4+ T cells in the mesenteric lymph nodes. Furthermore, we confirmed that these CD45RBhighCD69+CD4+ T cells are able to produce high levels of IFN-γ and moderate level of IL-4, IL-10, and IL-13. Conclusions: Dietary intake of FOS during the development of food allergy attenuates the induction of intestinal Th2 cytokine responses by regulating early activation of naïve CD4+ T cells, which produce both Th1 and Th2 cytokines. Our results suggest FOS might be a potential food agent for the prevention of food allergy by modulating oral sensitization to food antigens.
Evaluation of Mental Disorders Using Proton Magnetic Resonance Spectroscopy in Dialysis and Predialysis Patients
Authors: Zhang Chun-Yun , Chen Ying , Chen Shan , Kong Xiang-Chuang , Liu Yuan , You Chao-Qun , Wan Cheng , Bondzie Philip A. , Su Hua , Zhang Chun , He Fang-Fang
Published: November 2017

Background/Aims: Psychological complications are prevalent in patients with chronic kidney disease (CKD). This study aimed to investigate mental disorders in stage 4-5 CKD patients, to detect metabolite concentrations in the brain by proton magnetic resonance spectroscopy (1H-MRS) and to compare the effects of different dialysis therapies on mental disorders in end-stage renal disease (ESRD). Methods: The sample population was made up of predialysis (13), hemodialysis (HD) (13), and peritoneal dialysis (PD) patients (12). We collected the baseline data of patients’ age, sex, hemoglobin (Hb) and parathyroid hormone（PTH） levels. The predialysis patients served as the control group. The psychological status of the three groups was assessed using three psychological scales. 1H-MRS was used to evaluate the relative metabolite concentrations in the bilateral amygdala, hippocampus and unilateral anterior cingulated cortex (ACC). Results: The psychological status was better in HD patients than in predialysis and PD patients. 1H-MRS alterations were predominantly found in the ACC. Choline-containing compounds relative to creatine (Cho/Cr), myo-inositol relative to creatine (MI/Cr) and glutamate and glutamine relative to creatine (Glx/Cr) in the ACC were higher in HD patients. 1H-MRS results were correlated with the baseline data and the scores of psychological scales. Conclusions: CKD patients showed different types of mental disorders as well as metabolite disturbances in the brain. The metabolite concentrations correlated with the psychological status which was better in HD than in predialytic and PD patients.
A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary Effusion Lymphoma-Like Lymphoma
Authors: Usuda Daisuke , Arahata Masahisa , Takeshima Kento , Sangen Ryusho , Takamura Akiteru , Kawai Yasuhiro , Kasamaki Yuji , Iinuma Yoshitsugu , Kanda Tsugiyasu
Published: November 2017

A 93-year-old female was transferred to the emergency ward of our hospital due to disturbance of consciousness and hypotension. Computed tomography showed bilateral pleural and pericardial effusion without evidence of tumor masses or lymphadenopathy. Cytodiagnosis of pleural effusion revealed proliferation of atypical lymphoid-like cells with pan-B surface markers. We suspected primary effusion lymphoma-like lymphoma; however, the monoclonality of these cells was not confirmed. Cytodiagnosis of bone marrow revealed lymphoma cells with monoclonal B-cell markers. These findings prompted a diagnosis of diffuse large B-cell lymphoma with bone marrow invasion. In the case of pericardial or pleural effusion, clinicians should consider carefully both hematological malignancy and its classification.