bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Different Therapeutic Schedules on Patients with COVID-19: A Prospective Case–Control Study in China
Authors: Wu Jian , Wang Yuan , Cai Zhaobin , Lin Zechen , Huang Haijun , Wang Dawei , Yu Jiong , Jiang Bin , Zhao Xinguo , Zhai Guanghua , Lin Shengyou , Li Lanjuan , Cao Hongcui
Published: June 2022

Background and Aims. At present, a targeted drug has not been found for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study assessed the effects of different therapeutic schedules on patients with COVID-19. Methods. The clinical characteristics, the prognosis of patients with western medicine (WM) treatment, and the combination of traditional Chinese medicine and western medicine (TCM-WM) treatment were retrospectively explored from January 20, 2020 to February 20, 2021. Results. 19 patients (15.20%) and 7 patients (5.60%) in the WM treatment group developed into severe type and critically ill, which were higher than 5 patients (9.43%) and 0 patients (0.00%) in the TCM-WM treatment group (p=0.306andp=0.08). The time from admission to severe in the WM treatment group was significantly shorter than that of the TCM-WM treatment group (7.5 vs. 11.2,p<0.001). Compared with patients in the TCM-WM treatment group, the average stay time and the negative nucleic acid time of patients in the WM treatment group were both significantly longer (bothp<0.05). Besides, there existed no statistical difference for the safety of the two treatment options and nucleic acid test positive 14 days after discharge between the two groups. In line with the performance for severe patients, the average stay, the nucleic acid negative time, and the days of hormone therapy in the WM treatment group were all significantly longer than that of the TCM-WM treatment group (32.5 vs. 18.8,p<0.001; 24.5 vs. 14.5,p<0.001; 6.5 vs. 3.0,p<0.001). Conclusions. TCM-WM has better performance in both the disease progression and treatment of severe patients. We recommended that timely TCM-WM should be treated with patients with COVID-19.
Systemic Relapse in a Young Adult Patient with Primary CNS Diffuse Large B-Cell Lymphoma
Authors: Khorasanchi Adam , Benson Zachary , Hall Misty , Ebadirad Nelya , Gharavi Mohammad H. , Willard Patrick , Chimzar Miranda , McKay John , Simmons Gary , Yazbeck Victor
Published: June 2022

Primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is a rare form of non-Hodgkin’s lymphoma, characterized by an aggressive disease course. While CNS relapse is common, systemic relapse is rare with no consensus on optimal treatment. This paper presents an unusual case of advanced PCNS-DLBCL with systemic relapse, including adrenal gland involvement. A review of the existing literature and a discussion on the management of systemic relapse in PCNS-DLBCL is also provided.
Molecular Docking and In Silico Simulation of Trichinella spiralis Membrane‐Associated Progesterone Receptor Component 2 (Ts-MAPRC2) and Its Interaction with Human PGRMC1
Authors: Aleem Muhammad Tahir , Khan Asad , Wen Zhaohai , Yu Zhengqing , Li Kun , Shaukat Aftab , Chen Cheng , -Rehman Tauseef-ur , Lu Mingmin , Xu Lixin , Song Xiaokai , Li Xiangrui , Yan Ruofeng
Published: June 2022

Background. Trichinellosis is a foodborne zoonotic disease caused by Trichinella spp., including Trichinella spiralis. This parasitic disease ranks as seven of the most infectious in the world. In this context, it is important to develop a vaccine that can combat Trichinellosis, especially for humans and pigs. This would be an important step in preventing transmission. In this study, we focus on homology modelling, binding site prediction, molecular modelling, and simulation techniques used to explore the association between Trichinella spiralis membrane‐associated progesterone receptor component 2 (Ts-MAPRC2) and the human PGRMC1 protein. It was found that the progesterone receptor component 2 of T. spiralis has 44.54% sequence identity with human PGRMC1 (PDB ID: 4X8Y). Binding sites predicted for human PGRMC1 are GLU 7, PHE 8, PHE 10, PHE 18, LEU 27, ASP 36, and VAL 104. Molecular docking has six clusters based on Z scores. They range from ‐1.5 to 1.8. It was found that the progesterone receptor component 2 of T. spiralis has 44.54% sequence identity with human PGRMC1. During simulation, the average RMSD was 2.44 ± 0.20 Å, which indicated the overall stability of the protein. Based on docking studies and computational simulations, we hypothesized that the interaction of the proteins Trichinella spiralis membrane‐associated progesterone receptor component 2 and human PGRMC1 formed stable complexes. The discovery of Ts-MAPRC2 may pave the way for the development of drugs and vaccines to treat Trichinellosis.
Statistically Based Assessment and Decision-Making in Preschool Education
Authors: Wang Zimin , Dong Weijian
Published: June 2022

Preschool education is the beginning of lifelong learning, an important part of the national educational system, and an important social welfare undertaking. At the same time, as an important public service, preschool education is an important task to realize the adjustment of income redistribution to ensure that its financial investment is in line with fairness. Since 2010, the preschool educational policy in China has clearly been tilted toward rural areas and poverty-stricken areas in the central and western regions. Based on the 2010–2020 China Education Statistical Yearbook data, this study monitors and measures the completion of the formal goals put forward in the policy document and evaluates the effectiveness of the policy based on the comparison of the development levels of preschool education in urban areas, townships, and rural areas in China. The results show that under the effect of preferential policies, preschool educational resources at the township level in China have rapidly expanded and the level of popularization has improved; the number of township kindergarten teachers has been supplemented, and the educational level has been significantly improved. But at the same time, it is found that the advantages of inclusive preschool educational resources in areas with preferential policies are not obvious; inclusive preschool educational resources are obviously insufficient; and the proportion of children studying in private kindergartens is increasing year by year. The number of kindergarten teachers is still in short supply, and the ratio of students to teachers in rural kindergartens is much higher than in urban areas. The gap in teacher levels is still very large.
Application of Care Bundles in Postanesthesia Recovery for Elderly Patients with Colorectal Cancer
Authors: Yu Xiaoling , Chen Lichai , Chen Shuyi , Qian Weiming , Fang Lili
Published: June 2022

Objective. Based on the postanesthesia recovery procedure for elderly patients with colorectal cancer, a care bundle program was conducted to validate its effectiveness. Method. According to the characteristics of elderly patients with colorectal cancer, five measures including respiratory management, circulatory stability, pain assessment, body temperature monitoring, and internal environment stability were integrated into one bundle. Postanesthesia care unit (PACU) care bundle program for elderly patients was developed and used to improve recovery care. The monitoring data of the pre-PACB group given care bundles were collected and compared with the data of the post-PACB group who were given conventional recovery care. Result. 222 patients in post-PACB group had shorter intubation time than 291 patients in pre-PACB group (

37.7
±
24.4
 
min

vs.

42.1
±
23.3
 
min

,

P
<
0.05

). The length of stay in PACU was longer in pre-PACB group (

89.9
±
33.5
 
min

vs.

81.6
±
31.1
 
min

,

P
<
0.05

). More adverse events were found in the post-PACB group than in the pre-PACB group (72.1% vs. 34.0%). Conclusion. After general anesthesia of patients with colorectal cancer, the application of the care bundles can improve the quality of recovery, shorten the intubation time and the length of stay in PACU, and reduce the complications caused by anesthesia.
Robot Coworkers: The Vision of Future Hoteliers
Authors: Carvalho Inês , Lopes Sofia , Madeira Arlindo , Palrão Teresa , Mendes Alexandra S.
Published: June 2022

The purpose of this study is to understand how future employees in the hospitality and tourism industry envision the use of artificial intelligence in the organizations where they wish to work in the future. Through open-ended questions applied to undergraduate and master’s students in the area of tourism and hospitality, we capture their opinions when thinking about the partial or total use of robots in hospitality. Despite the increasing implementation of artificial intelligence in hospitality and tourism, existing research mainly focuses on current hoteliers and/or customers. However, anticipating how digital generations expect their future roles in a close engagement with robots allows researchers to predict and focus their attention on future problems. Their statements were subjected to a qualitative content analysis methodology, based on themes and sentiment. Participants expressed a negative view of the presence of robots in hospitality, mostly associated with a fear of job loss. Many also reported that interacting with robots is negative for both staff and customers due to robots’ lack of emotions. However, there is some division concerning the impact of robots on service quality: some believe that the service will be more efficient and with fewer failures; others believe that the limitations of robots will lead to worse service. The findings suggest that the acceptability and desirability of robotization may vary depending on the level of robotization in hotels, on the type of customer, and on the level of service provided.
Interpretation of Online Artworks of Digital Art Design in the New Media Environment
Authors: Li Pingping
Published: June 2022

In order to realize the interpretation of online artworks, the art design of artworks is studied on the basis of new media digital environment. Through the presentation of digital works, the enhancement of dramatic art appreciation, the balanced display of art appreciation, and the enhancement of digital aesthetic creation, the interpretation of artworks has been successfully completed, which strongly supports the digitization of new media. Art design is to constantly breed an updated online art space and attract and summon more viewers’ new experience, new creation, and new perception so as to trigger and develop new propositions, new exploration, and new atmosphere of new media drama. For the current construction of traditional art design, new media digital technology plays a major role. The transformation of digital technology and Internet media is another “holographic” extension of the human body, which has an extremely strong impact on new media art and comprehensively updated our life, art, and aesthetic concepts. This is not only a revolution of media but also a change of art. At the same time, it is also accompanied by the “expansion” of art theory. What this change ultimately needs to complete is the revolution of media culture that affects the development process of human civilization.
A Robust Graph Theoretic Solution of Routing in Intelligent Networks
Authors: Qureshi Muhammad Aasim , Hassan Mohd Fadzil , Ehsan Muhammad Khurram , Khan Muhammad Owais , Ali Md YeaKub , Khan Shafiullah
Published: June 2022

Implementation of robust routing is very critical in network communication. Connecting devices like routers maintain databases for the whole network topology in the routing table. Each router needs to keep these tables updated with the best possible routes so that an efficient communication can always take place in nondelay tolerant intelligent networks that include military and tactical systems, vehicular communication networks, underwater acoustic networks, and intelligent sensor networks. The fast construction of shortest-path tree (SPT) is important to devise an efficient routing in a nondelay tolerant networks. That is why a simple and efficient algorithm is the need of the time. A robust routing solution SPT with

O

V
+
E

time complexity is proposed to supersede the existing landmark.
Prevalence and Associated Factors of Hypertension among Women in Southern Ghana: Evidence from 2014 GDHS
Authors: Dorgbetor Cyprian Issahaku , Dickson Kwamena Sekyi , Kwabena Ameyaw Edward , Setorwu Adde Kenneth
Published: June 2022

Background. Hypertension, coupled with prehypertension and other hazards such as high blood pressure, is responsible for 8·5 million deaths from stroke, ischaemic heart disease, other vascular diseases, and renal disease worldwide. Hypertension is the fifth commonest cause of outpatient morbidity in Ghana. Some evidence have illustrated geographical variation in hypertension and it seems to have a heavy toll on women in southern Ghana compared to the north. This study seeks to determine the prevalence and associatedfactors of hypertension among women in southern Ghana using the most recent demographic and health survey (DHS) data set. Materials and Methods. This study used data of 5,662 women from the current DHS data from Ghana that was conducted in 2014. Data were extracted from the women’s file of the 2014 Ghana DHS. The outcome variable of this current study was hypertension and it was measured by blood pressure, according to guidelines of the Joint National Committee Seven (JNC7). Multivariable binary logistic regression analyses were performed to establish the factors associated with hypertension at the individual and community levels. Results. Prevalence of hypertension among women in southern Ghana was 16%. Women aged 40–44 years (aOR = 8.04, CI = 4.88–13.25) and 45–49 years (aOR = 13.20, CI = 7.96–21.89] had the highest odds of hypertension relative to women aged 15–19 years. Women with two births (aOR = 1.45, CI = 1.01–2.07) and those with three births (aOR = 1.47, CI = 1.01–2.15) had a higher likelihood of being hypertensive. Greater Accra women had higher odds (aOR = 1.35, CI = 1.02–1.79) of being hypertensive relative to the reference category, women from the Western region. Women of Guan ethnicity had a lesser likelihood (aOR = 0.54, CI = 0.29–0.98) of being hypertensive. Women who engaged in agriculture had the least likelihood (aOR = 0.72, CI = 0.52–0.99) of being classified hypertensive compared to unemployed women. Conclusion. This study has revealed the prevalence of hypertension among women in southern Ghana. The associated factors include age, parity, region, and occupation. As a result, existing interventions need to be appraised in the light of these factors. Of essence is the need for Ghana Health Service to implement wide-embracing health promotion initiatives that accommodate the nutritional, exercise, and lifestyle needs of women in southern Ghana. Having more children is associated with higher propensity of hypertension and consequently, women need to limit childbearing to reduce their chances of being hypertensive. It will also be advisable for women in the Greater Accra region to have frequent hypertension screening, as women in the region exhibited higher hypertension prospects.
Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival
Authors: Roszik Jason , Lee J. Jack , Wu Yi-Hung , Liu Xi , Kawakami Masanori , Kurie Jonathan M. , Belouali Anas , Boca Simina M. , Gupta Samir , Beckman Robert A. , Madhavan Subha , Dmitrovsky Ethan
Published: June 2022

Inflammation is a cancer hallmark. NSAIDs improve overall survival (OS) in certain cancers. Real-world studies explored here whether NSAIDs improve non–small cell lung cancer (NSCLC) OS. Analyses independently interrogated clinical databases from The University of Texas MD Anderson Cancer Center (MDACC cohort, 1987 to 2015; 33,162 NSCLCs and 3,033 NSAID users) and Georgetown-MedStar health system (Georgetown cohort, 2000 to 2019; 4,497 NSCLCs and 1,993 NSAID users). Structured and unstructured clinical data were extracted from electronic health records using natural language processing (NLP). Associations were made between NSAID use and NSCLC prognostic features (tobacco use, gender, race, and body mass index, BMI). NSAIDs were statistically significantly (P < 0.0001) associated with increased NSCLC survival (5-year OS 29.7% for NSAID users vs. 13.1% for nonusers) in the MDACC cohort. NSAID users gained 11.6 months over nonusers in 5-year restricted mean survival time. Stratified analysis by stage, histopathology, and multicovariable assessment substantiated benefits. NSAID users were pooled independent of NSAID type and by NSAID type. Landmark analysis excluded immortal time bias. Survival improvements (P < 0.0001) were confirmed in the Georgetown cohort. Thus, real-world NSAID usage was independently associated with increased NSCLC survival in the MDACC and Georgetown cohorts. Findings were confirmed by landmark analyses and NSAID type. The OS benefits persisted despite tobacco use and did not depend on gender, race, or BMI (MDACC cohort, P < 0.0001). These real-world findings could guide future NSAID lung cancer randomized trials.

Significance:

NLP and real-world studies conducted in large cohorts explored whether NSAIDs improved survival across NSCLC stages, histopathology, gender, smoking history, or demographic groups. A statistically significant association between NSAID use and NSCLC survival was found. This provides a rationale for future NSAID randomized NSCLC trials.
Society for Cardiovascular Magnetic Resonance/European Society of Cardiovascular Imaging/American Society of Echocardiography/Society for Pediatric Radiology/North American Society for Cardiovascular Imaging Guidelines for the Use of Cardiac Magnetic Resonance in Pediatric Congenital and Acquired Heart Disease: Endorsed by The American Heart Association
Authors: Fogel Mark A. , Anwar Shaftkat , Broberg Craig , Browne Lorna , Chung Taylor , Johnson Tiffanie , Muthurangu Vivek , Taylor Michael , Valsangiacomo-Buechel Emanuela , Wilhelm Carolyn
Published: June 2022

Cardiovascular magnetic resonance has been utilized in the management and care of pediatric patients for nearly 40 years. It has evolved to become an invaluable tool in the assessment of the littlest of hearts for diagnosis, pre-interventional management and follow-up care. Although mentioned in a number of consensus and guidelines documents, an up-to-date, large, stand-alone guidance work for the use of cardiovascular magnetic resonance in pediatric congenital 36 and acquired 35 heart disease endorsed by numerous Societies involved in the care of these children is lacking. This guidelines document outlines the use of cardiovascular magnetic resonance in this patient population for a significant number of heart lesions in this age group and although admittedly, is not an exhaustive treatment, it does deal with an expansive list of many common clinical issues encountered in daily practice.
New Insights Into Long- Versus Short-Term Dual Antiplatelet Therapy Duration in Patients After Stenting for Left Main Coronary Artery Disease: Findings From a Prospective Observational Study
Authors: Wang Hao-Yu , Dou Ke-Fei , Guan Changdong , Xie Lihua , Huang Yunfei , Zhang Rui , Yang Weixian , Wu Yongjian , Yang Yuejin , Qiao Shubin , Gao Runlin , Xu Bo
Published: June 2022

Background:

The appropriate duration of dual antiplatelet therapy (DAPT) and risk-benefit ratio for long-term DAPT in patients with left main (LM) disease undergoing percutaneous coronary intervention remains uncertain.

Methods:

Four thousand five hundred sixty-one consecutive patients with stenting of LM disease at a single center from January 2004 to December 2016 were enrolled. Decision to discontinue or remain on DAPT after 12 months was left to an individualized decision-making based on treating physicians by weighing the patient’s risks of ischemia versus bleeding and considering patient preference. The primary outcome was a composite of death, myocardial infarction, stent thrombosis, or stroke at 3 years. Key safety outcome was 3-year rate of Bleeding Academic Research Consortium 2, 3, or 5 bleeding.

Results:

Of 3865 patients free of ischemic and bleeding events at 12 months, 1727 (44.7%) remained on DAPT (mostly clopidogrel based [97.7%]) beyond 12 months after LM percutaneous coronary intervention. DAPT>12-month versus ≤12-month DAPT was associated with a significant reduced risk of 3-year primary outcome (2.6% versus 4.6%; adjusted hazard ratio: 0.59 [95% CI, 0.41–0.84]). The same trend was found for other ischemic end points: death (0.9% versus 3.0%;
P
log-rank
<0.001), cardiovascular death (0.5% versus 1.7%;
P
log-rank
=0.001), myocardial infarction (0.8% versus 1.9%;
P
log-rank
=0.005), and stent thrombosis (0.4% versus 1.1%;
P
log-rank
=0.017). The key safety end point was not significantly different between 2 regimens (1.8% versus 1.6%; adjusted hazard ratio: 1.07 [95% CI, 0.65–1.74]). The effect of DAPT>12 month on primary and key safety outcomes was consistent across clinical presentations, high bleeding risk, P2Y
12
inhibitor, and LM bifurcation percutaneous coronary intervention approach.

Conclusions:

In a large cohort of patients free from clinical events during the first year after LM percutaneous coronary intervention and at low apparent future bleeding risk, an individualized patient-tailored approach to longer duration (>12 month) of DAPT with aspirin plus a P2Y
12
inhibitor (mostly clopidogrel) improved both composite and individual efficacy outcomes by reducing ischemic risk, without a concomitant increase in clinically relevant bleeding.
A Live Speech-Driven Avatar-Mediated Three-Party Telepresence System: Design and Evaluation
Authors: Jin Aobo , Deng Qixin , Deng Zhigang
Published: June 2022

In this article, we present a live speech-driven, avatar-mediated, three-party telepresence system, through which three distant users, embodied as avatars in a shared 3D virtual world, can perform natural three-party telepresence that does not require tracking devices. Based on live speech input from three users, this system can real-time generate the corresponding conversational motions of all the avatars, including head motion, eye motion, lip movement, torso motion, and hand gesture. All motions are generated automatically at each user side based on live speech input, and a cloud server is utilized to transmit and synchronize motion and speech among different users. We conduct a formal user study to evaluate the usability and effectiveness of the system by comparing it with a well-known online virtual world, Second Life, and a widely-used online teleconferencing system, Skype. The user study results indicate our system can provide a measurably better telepresence user experience than the two widely-used methods.
The Transformative Potential of Human Rights Education for Youth Engagement in the Community
Authors: Blanchet-Cohen Natasha , Grégoire-Labrecque Geneviève
Published: June 2022

This article examines the potential of human rights education (hre) for youth engagement in promoting human rights and children’s rights for diversity and inclusion. The retrospective study of Speaking Rights, a programme implemented by a community-based organisation for over a decade across Canada, presents the outreach, outcome and approach of youth-led community action projects (cap s). The accessible, practical, relational and reflective approach was generative. The iterative and multi-pronged work provided opportunities for broad outreach and awareness amongst a range of youth-serving organisations. We discuss the transformative prospects of the cap s as illustrative of a broadening of children’s rights and a renewal of hre, along with the limitations of bringing the emancipatory nature of hre to scale, and the need to allow for a critical stance throughout the hre process that includes supporting disruptive spaces to meaningfully tackle injustices.
Power, Politics and Children’s Citizenship: The Silencing of Civil Society
Authors: Osler Audrey , Kato Aya
Published: June 2022

Children remain marginalised in theoretical analyses of citizenship and political rights, with their partial citizenship status attracting minimal attention. We consider the ontological need for political engagement, children’s political agency and intergenerational justice. We discuss how Derrida’s hospitality concept may inform analyses of power structures that serve to exclude children from the demos. We then examine the case of Japan where education law neglects children’s political rights, though respect for human rights and popular sovereignty are core constitutional values. Analysis of parliamentary debates addressing Article 12 and children’s right to be heard and organise collectively reveals a long-standing ideological divide concerning children’s political participation. The Committee on the Rights of the Child has explained Japan’s reluctance to implement Article 12 as reflecting “traditional” attitudes. The reality is more complex. From the late 1950s, Japan experienced a wave of student-led protests, focusing on the US-Japan Anpo Security Treaty. Subsequently, the Japanese government prioritised public order over students’ political rights, and global economic competitiveness over citizenship rights. Article 12 remains a site of struggle between those wishing to extend children’s citizenship rights and those who wish to maintain their partial citizenship, fearing social unrest and a focus away from global economic competitiveness.
Who, or What, is Lost: Singapore’s Impressions of Christmas Island, c. 1960–1990
Authors: Chan Ying-kit
Published: June 2022

Although Singapore no longer governs Christmas Island, either on behalf of its British colonial administrators or for itself, some Singaporeans continue to regard it as a lost territory and have false impressions that it once belonged and should again belong to Singapore. By examining this complexity related to Christmas Island and its possible implications for Singapore’s national psyche, this paper surveys the newspapers of Singapore and oral history records of Singaporean ministers and officials for accounts of Christmas Island. It suggests that Singaporean newspapers’ portrayal of Christmas Island as a neglected Australian overseas territory contributed to some Singaporeans’ perception that Christmas Island might actually be better off with Singapore; others even had a misconception of Christmas Island as a lost territory. Such opinions have never really dissipated because the government has never publicly clarified the transfer of Christmas Island and rejected claims about its “sale” to Australia.
Marine Achnanthales (Bacillariophyceae) from New Caledonia (Melanesia): assemblage specificities, ultramafic environment
Authors: RIAUX-GOBIN CATHERINE , WITKOWSKI ANDRZEJ , COSTE MICHEL , BERTEAUX-LECELLIER VERONIQUE , DANISZEWSKA-KOWALCZYK GENOVEFA
Published: June 2022

The marine Achnanthales (Bacillariophyceae), with a particular focus on Cocconeidaceae, were investigated in a variety of habitats from the South Province of New Caledonia (Melanesia, Pacific Ocean). Species diversity ranged from species-poor and scarce assemblages on mangrove mud flats to highly diverse and abundant assemblages on short turfs and scrapings of aerial pneumatophores of Avicennia marina. Macroalgae (in place or as sea leash), as well as feces of Acanthopleura gemmata (invertebrate grazer, living on intertidal rocky environments), contained few diatoms, with low diversity. The New Caledonia assemblages show some taxa previously found in the tropical Indian Ocean. Several noteworthy taxa, listed as rare from Polynesia, are not uncommon in New Caledonia, such as Vikingea gibbocalyx and Cocconeis pseudodiruptoides. The notion of endemism concerning marine eukaryotes is approached.
Two new epiphytic species of Impatiens L. (Balsaminaceae) from the southern Western Ghats, India
Authors: SARAVANAN THOKULUVA SANTHARAM , KALIAMOORTHY SEVENTHILINGAM
Published: June 2022

Two new epiphytic species of Impatiens L. (Balsaminaceae), viz., Impatiens keralensis and Impatiens kurichiarmalayana are described from Wayanad district, Kerala, India. Impatiens keralensis is allied to I. modesta Wight and I. mohana Ratheesh, Sujana & Anil Kumar; and Impatiens kurichiarmalayana is to I. mankulamensis K. M. P. Kumar, R. Jagad. & Nagaraj and I. panduranganii K. M. P. Kumar, R. Jagad. & G. Prasad. The newly described taxa are readily distinguishable from their allied species by unique character combinations viz., leaf size, leaf, margin, lateral sepal, lower sepal, dorsal petal, wing petal and seeds. Detailed descriptions along with photographs and comparison tables are provided.
Near-Inertial Wave Interactions and Turbulence Production in a Kuroshio Anticyclonic Eddy
Authors: Essink Sebastian , Kunze Eric , Lien Ren-Chieh , Inoue Ryuichiro , Ito Shin-ichi
Published: June 2022

Interactions between near-inertial waves and the balanced eddy field modulate the intensity and location of turbulent dissipation and mixing. Two EM-APEX profiling floats measured near-inertial waves generated by Typhoons Mindulle, 22 August 2016, and Lionrock, 30 August 2016, near the radius of maximum velocity of a mesoscale anticyclonic eddy in the Kuroshio–Oyashio confluence east of Japan. High-vertical-wavenumber near-inertial waves exhibit energy fluxes inward toward eddy center, consistent with wave refraction/reflection at the eddy perimeter. Near-inertial kinetic energy tendencies are nearly two orders of magnitude greater than observed turbulent dissipation rates ε, indicating propagation/advection of wave packets in and out of the measurement windows. Between 50 and 150 m, ε ∼ (10−10) W kg−1, more than an order of magnitude weaker than outside the eddy, pointing to near-inertial wave breaking at different depths or eddy radii. Between 150 and 300 m, small-scale inertial-period patches of intense turbulence with near-critical Ri occur where comparable near-inertial and eddy shears are superposed. Three-dimensional ray-tracing simulations show that wave dynamics at the eddy perimeter are controlled by radial gradients in vorticity and Doppler shifting with much weaker contributions from vertical gradients, stratification, and sloping isopycnals. Surface-forced waves are initially refracted downward and inward, consistent with the observed energy flux. A turning-point shadow zone is found in the upper pycnocline, consistent with weak observed dissipation rates. In summary, the geometry of wave–mean flow interaction creates a shadow zone of weaker near-inertial waves and turbulence in the upper part while turning-point reflections amplify wave shear leading to enhanced dissipation rates in the lower part of the eddy.
The University of Alabama at Birmingham Surgery Community Network: Tackling the Challenges of Rural Surgery
Authors: Kraus Abigayle C. , Gunnells Drew J. , Chu Daniel I. , Kennedy Alexis E. , Hughes Tyler G. , Chen Herb , Hollis Robert H. , Porterfield John R. , Stahl Richard D. , Kennedy Gregory D.
Published: June 2022

Over the past 5 years, The University of Alabama at Birmingham (UAB) Department of Surgery has taken a keen interest in the practice of surgery in rural Alabama and has established the UAB surgery community network. Our goal is to improve the delivery of surgical care in rural areas through active recruitment of rural surgeons, the development of research around rural surgery practice, and the expansion of a surgery network throughout the state. Here, we will present the challenges faced by rural surgery, our early work to address these challenges, and offer a plan for moving forward.
High-Grade Colonic Stricture After a Severe Case of COVID-19 Pneumonia
Authors: Jarvis Nicholas R. , Mishra Nitin
Published: June 2022

Extrapulmonary involvement of coronavirus-19 disease (COVID-19) is being documented and studied at an increasing frequency. Specifically, gastrointestinal involvement is hypothesized to occur due to cellular entry via the ACE2 receptor found in gastrointestinal epithelial cells, causing inflammation and symptoms such as abdominal pain, nausea/vomiting, and diarrhea. We present the case of a 45-year-old female with recent severe COVID-19 infection and early gastrointestinal symptoms who later presented with worsening abdominal pain, nausea, vomiting, and constipation after initial discharge. She was diagnosed with a large bowel obstruction and underwent urgent exploratory laparotomy, which revealed a stricture of the distal transverse colon. Following segmental resection, the patient experienced resolution of symptoms. We hypothesize that this patient’s colonic stricture arose secondary to severe COVID-19-induced bowel inflammation.
Adherence Patterns and Acceptability of a Perioperative, App-Based Mindfulness Meditation Among Surgical Patients With Chronic Pain
Authors: Diller Maggie L. , Mascaro Jennifer , Haack Carla , Master Viraj
Published: June 2022

Identifying barriers to compliance with mindfulness-based interventions (MBIs) during the perioperative period is paramount to the design and implementation of non-pharmacologic, opiate-sparing pain regimens. We prospectively investigated the acceptability and adherence patterns of an app-based MBI amongst surgical patients with chronic pain. Patients were provided a subscription code to a meditation app and encouraged to use the app an average of 10 minutes/day over a 6-week study period. Patients reported a high level of interest in using the app prior to enrollment. 71% used the app at least once, 30% for half the recommended time, and 8% for the recommended amount of time. 88% of respondents enjoyed using the app and agreed it improved mental health and stress levels. Surgical patients with pre-existing pain report a high level of interest in utilizing MBIs perioperatively. Identifying barriers to compliance represents an important area of future investigation.
Reading and Math Achievement in Children With Dyslexia, Developmental Language Disorder, or Typical Development: Achievement Gaps Persist From Second Through Fourth Grades
Authors: Duff Dawna M. , Hendricks Alison E. , Fitton Lisa , Adlof Suzanne M.
Published: June 2022

We examined how children ( N = 448) with separate or co-occurring developmental language disorder (DLD) and dyslexia performed on school-based measures of academic functioning between second and fourth grades. Children were recruited from 1 school district in the U.S. state of South Carolina via classroom screenings and met common research criteria for DLD and dyslexia. Growth curve models were used to examine the overall form of growth and differences between groups. Children with DLD and/or dyslexia in second grade showed early and persistent deficits on school-administered measures of reading and math. In second grade, children with typical development (TD) scored significantly higher than children with dyslexia-only and DLD-only, who did not differ from each other. Children with DLD+dyslexia scored significantly lower than all other groups. Only small differences in growth rates were observed, and gaps in second grade did not close. Despite lower academic performance, few children (20%–27%) with dyslexia and/or DLD had received specialized support services. Children with DLD-only received services at less than half the rate of dyslexia-only or DLD+dyslexia despite similar impacts on academic performance. Evidence of significant and persistent functional impacts in the context of low rates of support services in these children—especially those with DLD-only—highlights the need to raise awareness of these disorders.
Investigation of the Relationship Between COVID-19 Anxiety and Perception of Risk in Pregnancy, Fears of Death and Losing Their Baby in the Pandemic
Authors: Durmaz Aysegul , Gun Kakasci Ciğdem
Published: June 2022

The aim of the study was to determine Covid-19 anxiety, obsession, perception of risk and self-care agency levels of pregnant women during the pandemic and investigate the association between Covid-19 anxiety, obsession, perception of risk and self-care agency levels and the fears of death and losing their baby in the pregnant women. The study was a cross-sectional and descriptive study. Five hundred thirty-eight pregnant women were included in the study. “COVID-19 Anxiety Scale,” “COVID-19 Obsession Scale,” “Risk Perception in Pregnancy Scale,” and “The Exercise of Self-Care Agency Scale” were used to collect data of the study. In this study, the total Cronbach’s alpha reliability coefficients of the COVID-19 Anxiety Scale, COVID-19 Obsession Scale, The Perception of Pregnancy Risk Questionnaire, The Exercise of Self-Care Agency Scale were found to be 0.73, 0.70, 0.86 and 0.95 respectively. Statistical analysis of data in the study was conducted using SPSS (22.0, IBM Corp. Armonk, NY) statistical program. Statistically significant differences were identified between the mean score from COVID-19 anxiety scale and the mean scores from COVID-19 obsession scale, the perception of pregnancy risk questionnaire and the exercise of self-care agency scale. These results suggest that education and health policies that focus on the health of pregnant women and their fetus should be developed for antenatal care services.
Does Physical Activity Improve Inhibition in Kindergarteners? A Pilot Study
Authors: Giordano Giulia , Alesi Marianna
Published: June 2022

Substantial empirical evidence supports the positive effects of physical activity (PA) on executive functions, but not all forms of physical activity benefit equally. Among kindergarteners, cognitively-engaging exercise seems to more strongly effect EF than simple exercise. We aimed to investigate several qualitatively different exercise formats on kindergarteners' inhibition. Participants were 75 children (M age = 68.1 months), recruited from 14 classrooms of three kindergarten schools. They were randomly assigned to three groups: control group, free play group (non-cognitively-engaging PA), and an intervention group (cognitively-engaging PA). The intervention group performed 18 sessions of a cognitively engaging PA (tasks requiring movements and inhibitory behavior skills). We assessed “hot” and “cool” aspects of inhibition using the Day-Night Stroop test, Head-Shoulders-Knees-Toes, Gift Wrap, and Snack Delay. We found that the intervention group obtained a more consistent performance improvement on post-test measures of hot and cool inhibition than did the free play group.
Preclinical In Vivo Safety of Poly-Phosphorylated Superlubrication Vectors for the Treatment of Osteoarthritis
Authors: Ramot Yuval , Dolkart Oleg , Steiner Michal , Jahn Sabrina , Goldberg Ronit , Cacical Orna , Lavie Yossi , Ezov Nati , Agar Gabi , Nyska Abraham
Published: June 2022

Osteoarthritis (OA) can lead to a significant functional disability. Poly[2-(methacryloyloxy)ethyl phosphorylcholine] (pMPC) liposomes are a novel treatment modality for OA, intended to restore the natural lubrication properties of articular cartilage. Here, we report on two studies aimed to assess the local and systemic safety and toxicity of pMPCylated liposomes in comparison with physiological saline, in Sprague-Dawley (SD) rats and in sheep after a single intra-articular (IA) injection. The animals were sacrificed after 1 and 6 weeks (rats) and 3 and 6 weeks (sheep). No signs of toxicity or abnormal clinical findings were observed. Histopathological evaluation revealed no signs of reactivity or abnormal findings in the injected joints or in any other organs. In conclusion, a single IA injection of the pMPCylated liposomes demonstrated an excellent safety profile and did not result in local reactivity or systemic toxicity, thus supporting its further development for use in humans.
Financial Inclusion Through Banking for the Poor: A Study on Cycle Rickshaw Pullers in West Bengal
Authors: Maity Sudarshan , Sahu Tarak Nath , Biswas Debasish
Published: June 2022

Financial services actively contribute to the economic development of society. This leads to social safety that protects people from economic shocks. The present study seeks to ascertain whether cycle rickshaw pullers of West Bengal have bank accounts and to also investigate if bank account awareness among cycle rickshaw pullers are affected by different socio-economic factors. The study has been conducted on 170 rickshaw pullers who belong to the poor and marginalized sections of society. The study uses logistic regression to estimate important factors that influence the opening of a bank account. The goodness of fit of the model is checked in terms of the Hosmer–Lemeshow test. A large percentage of this group of rickshaw pullers is excluded from banking services. Among the 10 explanatory variables, the study finds that the number of years pulling cycle rickshaws, the monthly income and social participation are the factors that significantly influence the opening of a bank account. It has been observed that the respondents have meager incomes, low levels of health care and personal well-being, lives entrapped in poverty and are, on the whole, excluded from the mainstream. To include them in the mainstream financial services, the study suggests valid recommendations to draw the attention of the regulators and banks towards financial inclusion.

JEL Codes: G21, G29
Are there really specific risk factors for heterotopic ossifications? A case report of ‘non-risk factor’ after total hip replacement
Authors: Stołtny Tomasz , Pasek Jarosław , Rokicka Dominika , Wróbel Marta , Dobrakowski Michał , Kamiński Paweł , Domagalski Rafał , Czech Szymon , Strojek Krzysztof , Koczy Bogdan
Published: June 2022

Femoral neck fractures are one of the most common fractures in the elderly population. Due to frequent complications of the fixation of these fractures, patients are more and more often eligible for hip replacement surgery. One of the most frequently mentioned postoperative complication is the formation of heterotopic ossification. This case report describes as a 70-year-old male patient that presented with an old hip fracture accompanied by a mild craniocerebral trauma. The patient underwent total cementless hip arthroplasty followed by rehabilitation. At 8 months after surgery, the patient was diagnosed with Brooker IV° heterotopic ossification in the area of the operated hip joint. Due to the persistent pain and complete loss of mobility in the operated joint, computed tomography imaging was performed and the patient was recommended for a revision surgery. The procedure was performed 14 months after the original surgical treatment, resulting in a significant improvement in the range of motion and reduction of pain.
Assessing the Impact of Community Factors on Acute Care Nurses’ Job Satisfaction and Turnover Intention
Authors: Yasin Yasin M. , Kerr Michael S. , Wong Carol A. , Bélanger Charles H.
Published: June 2022

Background

Community factors may affect nurses’ job behavior and decision making. There is a gap in the literature regarding the impact of community satisfaction, family ties, and community preferences on acute care nurses’ turnover intention and job satisfaction. Furthermore, no studies have examined the differences in community satisfaction, community preferences, and family ties among nurses working in rural and urban settings.

Purpose

To identify the impact of family ties, community satisfaction, and community preferences on turnover intention and job satisfaction among acute care nurses working in Ontario's urban and rural areas.

Methods

Descriptive correlational survey design was used in this study. A targeted stratified sampling technique was used to recruit acute care nurses working in Ontario's urban and rural areas (N = 349) between May 2019 and July 2019. Dillman's approach was used to guide data collection. Parametric and non-parametric tests were used for data analysis.

Results

A significant association was found between working settings and community preferences. A statistically significant positive relationship between community satisfaction and nurses’ job satisfaction was identified. Furthermore, community satisfaction had a negative impact on turnover intention. Neither community preference nor family ties were significantly associated with turnover intention or job satisfaction.

Conclusion

The study suggests that community satisfaction can influence important nurse work-related outcomes. Future studies should replicate and validate these results in different contexts and cultures. Retaining nurses may be difficult if they are not satisfied with their communities.
Cryo-Temperature Pretreatment Increases the Pro-Angiogenic Capacity of Three-Dimensional Mesenchymal Stem Cells via the PI3K-AKT Pathway
Authors: Zhu Huasu , Zhuang Yong , Li Dong , Dong Na , Ma Huixian , Liu Linghong , Shi Qing , Ju Xiuli
Published: June 2022

To increase the potential and effectiveness of three-dimensional (3D) mesenchymal stem cells (MSCs) for clinical applications, this study explored the effects of short cryo-temperature pretreatment on MSC function. Adipose-derived MSCs (A-MSCs) were cultured via the ordinary monolayer method and 3D hanging drop spheroid method. When the cells adhered to the wall or formed a spheroid, they were subjected to hypothermic stress at 4°C for 1 h and then divided into three recovery periods at 37°C, specifically 0, 12, and 24 h. The control group was not subjected to any treatment throughout the study. Monolayer and 3D spheroid A-MSCs were analyzed via RNA sequencing after hypothermic stress at 4°C for 1 h. Subsequently, each group of cells was collected and subjected to phenotype identification via flow cytometry, and mRNA expression was detected via reverse transcription–quantitative polymerase chain reaction analysis. Western blot analysis was performed to analyze the PI3K-AKT signaling pathway in A-MSCs. The effects of A-MSCs on angiogenesis in vivo were examined using a chick chorioallantoic membrane assay. Transwell assays were performed to determine whether the culture supernatant from each group could induce the chemotaxis of human umbilical vein endothelial cells (HUVECs). Three-dimensional spheroid culture did not change the phenotype of A-MSCs. The expression of fibroblast growth factors, hepatocyte growth factors, and other angiogenesis-related factors in A-MSCs was upregulated. A-MSCs subjected to hypothermic stress promoted angiogenesis under both monolayer and 3D spheroid cultures. Moreover, the chemotaxis of HUVECs to the 3D spheroid culture supernatant increased substantially. Short cryo-temperature pretreatment could stimulate 3D spheroid A-MSCs and activate the PI3K-AKT pathway. This approach has the advantages of promoting angiogenesis and maintaining cell viability.
Pluriversal Problems, Revolutionary Remedies
Authors: Seth Suman
Published: June 2022

This article offers a description of and engagement with a number of arguments that have been framed around the notion of ‘ontological symmetry’ or the promotion of a ‘pluriverse’ over a universe. I seek, first, to explain what problems scholars are seeking to solve with these interventions; second, I point to certain missteps that have been made as part of these solutions, particularly in relation to human-centredness in conceptions of practice-based ontologies; and third, I draw attention to the dangers involved in assuming that the pluriverse will not be governed by power imbalances similar to those found in a one-world world.