bluuebunny/crossref_metadata_2025 huggingface dataset:
Seroprevalence of SARS-CoV-2 in 10 Regional Capitals of Cameroon, October-December 2020
Authors: Sachathep Karampreet , Harris Tiffany , Duong Yen , Reid Giles , Dokubo Emily Kainne , Shang Judith , Ndongmo Clement , Gabriel Ekali , Tharp G , Dimite Laura , Okpu Gordon , Ogollah Francis , Nguafack Dubliss , Ntse Martin , Hrusa Gili , Yuengling Katherine , Tebbenhoff Megan , René Essomba , Françoise Ngo Sack , Felicity Naah Tabala , Assoumou Marie Claire Okomo , Bissek Anne , N’Dir Adama
Published: May 2023

Cameroon was among the most affected African countries during the first
wave of the COVID-19 pandemic; however, the true prevalence of
SARS-CoV-2 remains unknown. From October-December 2020 we conducted a
cross-sectional, age-stratified SARS-CoV-2 seroepidemiological survey at
30 purposively selected community-based sites across Cameroon’s 10
regional capitals, sampling 10,000 individuals aged 5 years or older. We
employed a parallel SARS-CoV-2 antibody testing algorithm (WANTAI ELISA
and Abbot Architect) to improve both the positive predictive value and
negative predictive value of seroprevalence. The overall weighted and
adjusted seroprevalence of SARS-CoV-2 antibodies across the 10 urban
capitals of Cameroon was 10.5% (95% CI: 9.1%-12.0%) among
participants aged ≥5 years. Of the 9332 participants, 730 males (13.1%,
95% CI: 11.5%-14.9%) had SARS-CoV-2 antibodies compared to 293
females (8.0%, 95% CI: 6.8%—9.3%). Among those who reported a
comorbidity at the time of testing, 15.8% (95% CI: 12.8%-19.4%) were
seropositive. We estimated that over 2 million SARS-CoV-2 infections
occurred in the 10 regional capitals of Cameroon between October and
December 2020, compared to 21,160 cases officially reported at that time
translating to one laboratory-confirmed case was reported for every 110
SARS-CoV-2 infections across the 10 urban capitals. This study’s
findings point to extensive and under-reported circulation of SARS-CoV-2
in Cameroon– an almost 100-fold more cases compared to the number of
cases reported to the World Health Organization. This finding highlights
the importance of conducting serosurveys, especially in settings where
access to testing may be limited and to repeat such surveys as part of
pandemic tracking.
Public Health Consequences of Sudan's Crisis in the Face of Global Donor Fatigue
Authors: Musa Muhammad Kabir , Abdulsalam Abdullateef , Haruna Usman Abubakar , Adamu Nuruddeen , Zakariya Farida , Shuaibu Asma’u Zailani , III Don Eliseo Lucero Prisno
Published: May 2023

The emergence of the crisis in Sudan has led to an overstretched
healthcare system therein, which has negatively impacted the public
health system of the nation. The WHO has noted the closure of roughly
sixteen hospitals since the start of the conflicts due to staff safety
concerns as well as a shortage of hospital supplies, consumables, and
medication. Due to ongoing conflicts and persistent political
instability, Sudan receives very little funding from donor organizations
to maintain its healthcare system, which worsens the nation’s general
public health architecture. Thus, amidst the ongoing crisis recent
floods in the country can further pose serious challenges like disease
outbreaks, starvation, infectious diseases, deteriorating health
infrastructure, and mental health issues. To successfully reduce the
severity of negative impacts on public health, the crisis must be ceased
and facilities reopened. A well-structured disease surveillance system
for infectious diseases should be established, pregnant women and
children under the age of five should be treated for free, and mental
health awareness and examination should be prioritized. The global
community must act expeditiously to mitigate the devastating effects of
this crisis.
Effect of a strong CYP3A4 inducer rifampin on the pharmacokinetics of SHR2554 in healthy Chinese volunteers: A drug-drug interaction study
Authors: Xu Pingsheng , Xu Sumei , shen qiuying , Zhong Xu-Feng , Li Xiaomin , Liu Wanli , Hu Xiaolei
Published: May 2023

Aims: A phase I open-label study assessed the effect of multiple oral
doses of a potent CYP3A4 inducer (rifampicin) on the pharmacokinetic
profile of SHR2554, a novel enhancer of zeste homolog 2 inhibitor (EZH2)
and CYP3A4 substrate. Methods: Eighteen adult Chinese healthy subjects
were enrolled in this study. All participants received a single oral
dose of SHR2554 (300 mg) on day 1, rifampin (600 mg) from day 4 to day
10 and day 12, the same dose was coadministered with SHR2554 (300 mg)
and rifampicin (600 mg) on day 11. The primary endpoints were SHR2554
exposure parameters. Lack of drug–drug interaction was concluded if
90% confidence intervals (CIs) for the ratio of area under the plasma
concentration–time curve (AUC) or maximum concentration (Cmax),
with/without oral rifampicin, were within a pre-specified interval
(0.80–1.25). Results: The Cmax, AUC0-t, and AUC0-∞ of administration
alone and coadministration with rifampin were 177.265 ±127.9889 ng/mL,
17.001 ± 8.4759 ng/mL; 672.12 ± 507.390 h*ng/mL, 38.58 ± 19.495 h*ng/mL;
and 721.50 ±514.386 h*ng/mL, 46.30 ± 20.750 h*ng/mL, respectively.
Coadministration with rifampin decreased the least-squares geometric
mean ratios of Cmax, AUC0-t, and AUC0-∞ by 89%, 93%, and 93%,
respectively. Well tolerance and acceptable safety profile showed during
the trial. Conclusion: The exposure of SHR2554 was significantly
decreased when coadministered with rifampicin. It is recommended to
avoid concomitant use of SHR2554 and strong inducers of CYP3A4.
Paraphrase Detection: Human vs. Machine Content
Authors: Wahle Jan Philip , Becker Jonas , Ruas Terry , Gipp Bela
Published: May 2023

The growing prominence of large language models, such as GPT-4 and ChatGPT, has led to increased concerns over academic integrity due to the potential for machine-generated content and paraphrasing. Although studies have explored the detection of human-and machine-paraphrased content, the comparison between these types of content remains underexplored. In this paper, we conduct a comprehensive analysis of various datasets commonly employed for paraphrase detection tasks and evaluate an array of detection methods. Our findings highlight the strengths and limitations of different detection methods in terms of performance on individual datasets, revealing a lack of suitable machine-generated datasets that can be aligned with human expectations. Our main finding is that human-authored paraphrases exceed machine-generated ones in terms of difficulty, diversity, and similarity implying that automatically generated texts are not yet on par with human-level performance. Transformers emerged as the most effective method across datasets with TF-IDF excelling on semantically diverse corpora. Additionally , we identify four datasets as the most diverse and challenging for paraphrase detection.
Effect of exercise imagery on mental health status during an epidemic
Authors: Wang Dingming , Xu Meng , ZOU Xiaojiao , Zhang Shuqing , Shi Linyu , Li Xiyan , Li Hao
Published: May 2023

The COVID-19 outbreak has restricted the freedom of ordinary people,
resulting in less activity and more negative emotions. Consequently, we
proposed a motor imagery training procedure to intervene in the mental
health problems of people with freedom restrictions. We conducted two
studies. Study 1 had 176 participants, including 93 in the freely
restricted group (Mage=19.66, SD=1.16), and 83 in the non-freely
restricted group (Mage=21.4, SD=1.16). The freely restricted group had
more negative emotions than the non-freely restricted group. Study 2 had
106 valid participants who were randomly divided into two groups with 48
in the experimental group (Mage=19.46, SD=0.87), who received motor
imagery training, and 58 in the control group (Mage=19.41, SD=0.94), who
did not receive motor imagery training. The posttest positive emotion
scores were significantly higher in the experimental group than in the
pretest, while the posttest positive emotion scores were lower in the
control group than in the pretest. This result confirms that motor
imagery training can effectively promote positive emotions of
sequestered individuals during a pandemic. Our study provides a solution
to reduce psychological problems, particularly the promotion of positive
affect, in personnel with restricted freedom in COVID-19 sequestration,
and in other personnel with restricted activities.
Investigation of storm track characteristics in a regional climate model over East Asia
Authors: Chang Eun-Chul , Byun Ui-Yong , Kim Joowan , Ahn Joong-Bae , Cha Dong-Hyun , Min Seung-Ki , Byun Young-Hwa
Published: May 2023

Studies have shown that regional climate models (RCMs) can simulate
local climates at a higher resolution for specific regions compared to
global climate models (GCMs), making dynamic downscaling using RCMs a
more effective approach. Therefore, RCMs have become valuable tools for
evaluating the potential impacts of climate change on specific regions
and for informing local adaptation strategies. To fully understand the
added value (AV) of RCMs, it is essential to understand how the
characteristics differ between land and ocean. The complex topography of
East Asia, including land and sea, makes it a suitable region for
evaluating the AV of RCMs. In this study, we compared two regional
simulations that integrated the same RCMs but employed different GCMs
from the Coordinated Regional Climate Downscaling Experiment for their
ability to simulate storm tracks in East Asia. The results of the RCMs
over a historical period were compared with their host Coupled Model
Intercomparison Project GCM projections and high-resolution reanalysis.
In mountainous regions, the AV of the RCMs weakened the bias of the GCM
and improved its agreement with the reanalysis. In plains and coastal
areas, owing to the increase in horizontal resolution in RCMs,
small-scale phenomena are well represented, and the storm track of RCMs
shows similar values to that of the GCM in maritime regions. This study
demonstrates the value of RCMs for improving the accuracy of climate
projections in East Asia, informing adaptation strategies, and enhancing
climate research.
Fast computation of cloud 3D radiative effects in dynamical models by optimizing the ecRad scheme
Authors: Ukkonen Peter , Hogan Robin J
Published: May 2023

Radiation schemes are fundamental components of weather and climate
models that need to be both efficient and accurate. In this work we
refactor ecRad, a flexible radiation scheme developed at the European
Centre for Medium-Range Weather Forecasts (ECMWF). The goal was to
improve performance especially with ecCKD, a new gas optics scheme that
requires only 32 spectral intervals in the longwave and shortwave to be
accurate. This speeds up ecRad considerably, but also reduces
performance due to short inner loops.We therefore carry out both higher-level code restructuring and
kernel-level optimizations for the radiative transfer solvers
TripleClouds and SPARTACUS. SPARTACUS computes cloud 3D radiative
effects, which have so far been neglected in large-scale models. We
exploit the lack of vertical loop dependencies in key computations by
merging the spectral and vertical dimensions, improving vectorization
and instruction-level parallelism.On the new AMD Rome-based ECMWF supercomputer, we obtain a 3-fold
speedup for both solvers when using 32-term ecCKD models. Combining
ecCKD with optimized code results in very fast yet accurate radiation
computations: with TripleClouds we achieve 1.7 TFLOPs and a throughput
of 621 columns/ms on a 128-core node. This is 11.5 times faster than
ecRad in Integrated Forecasting System cycle 47r3, which uses a more
noisy solver (McICA) and less accurate gas optics (RRTMG). SPARTACUS
with ecCKD is now 2.4 times faster than CY47r3-ecRad, making cloud 3D
radiative effects affordable to compute within large-scale models.
Preliminary results show that SPARTACUS slightly improves forecasts of
2-metre temperature and low clouds in the tropics.
The Width of the Martian Bow Shock and Implications on Thermalization
Authors: Nesbit-Östman Sara , Gunell Herbert , Hamrin Maria , Opgenoorth Hermann , Andersson Laila
Published: May 2023

In theory the width of the quasi-perpendicular bow shock ramp is on the
scale of a few electron inertial lengths, but as this work will show the
quasi-perpendicular bow shock at Mars is often wider. This is important
because it implies that the conditions at Mars create a behaviour at the
shock which cannot be described by current theory. Furthermore, the
width could affect processes at the shock such as energy transfer of the
ions and their subsequent thermalization. To investigate the cause of
the width, two sets of quasi-perpendicular bow shock crossings measured
by MAVEN are compared, one of unusual width (average 370 km or
5r$_{gi}$), and one of typical width (average 30 km or
0.7r$_{gi}$). These sets are labeled wide and thin shocks
respectively. It is seen that the wide shocks have no distinct overshoot
and have a higher level of magnetic field fluctuations than the thin
shocks. Factors that are known to affect the standoff distance, such as
the magnetosonic Mach number and mass loading of the solar wind by
planetary species, were found not to affect the width of the bow shock.
It is found that the temperature of the solar wind plasma increases more
as it passes through a wide than a thin shock, indicating that ions are
thermalized to a larger extent than at thin shocks. The
larger-than-predicted by theory width of the Martian quasi-perpendicular
bow shock indicate that there are conditions at Mars which we do not yet
understand.
Regional Features of the 20-30 Day Periodic Behavior in the Southern Hemisphere Summer Circulation
Authors: Liu Zhaoyu , Wang Lei
Published: May 2023

The Southern Hemispheric (SH) storm tracks exhibit a robust
intraseasonal periodicity of 20-30 days as the leading mode of
zonal-mean eddy kinetic energy. To what extent this hemispheric-scale
mode of variability translates to smaller scales remains debated. This
work studies the regional features of SH storm tracks through the
filtered variance of local finite-amplitude wave activity. While the
synoptic variance is zonally elongated over the storm track, we find a
strong enhancement of intraseasonal variability within the South Pacific
with a minimum strength of the storm track. This enhanced region is
marked with 20-30 day periodic behavior of local wave activity and
precipitation and is driven by enhanced variability of low-level eddy
heat flux on the same timescale. The local nature of 20-30 day
periodicity offers a potential source of intraseasonal predictability
for weather analysts and forecasters.
Constraining Sector-specific CO2 Fluxes using Space-based XCO2 Observations over the Los Angeles Basin
Authors: Roten Dustin , Lin John C. , Kort Eric A.
Published: May 2023

The concentration of carbon dioxide (CO2) in Earth’s atmosphere is
increasing due to human activities and the resulting effects on the
global climate system have initiated sev- eral policy-driven approaches
to reduce emissions of this greenhouse gas. Quantifying the
effectiveness of such policies requires both bottom-up and top-down
approaches to estimate CO2 emissions. This work investigates, for the
first time, the potential of using SAM observations from NASA’s OCO-3
instrument to disaggregate sector-specific emissions from instrument
observations. Optimized sector-specific timeseries were produced using
Bayesian inversion techniques and compared to proxy activity data from
the transportation, commercial maritime, and industrial sectors. Results
demonstrate that dense space-based observations of atmospheric CO2 are
capable of disentangling sector-specific CO2 fluxes, paving the way for
accurate monitoring of the effects of carbon-reduction policies and
operational carbon monitoring systems.
Enhancing regional seismic velocity model with higher-resolution local results using sparse dictionary learning
Authors: Zhang Hao , Ben-Zion Yehuda
Published: May 2023

We use sparse dictionary learning to develop transformations between
seismic velocity models of different resolution and spatial extent.
Starting with results in the common region of both models, the method
can be used to enhance a regional lower-resolution model to match the
style and resolution of local higher-resolution results while preserving
its regional coverage. The method is demonstrated by applying it to
two-dimensional Vs and three-dimensional VP and VS local and regional
velocity models in southern California. The enhanced reconstructed
models exhibit clear visual improvements, especially in the
reconstructed VP/VS ratios, and better correlations with geological
features. We demonstrate the improvements of the reconstructed model
relative to the original velocity model by comparing waveform simulation
results to observations. The improved fitting to observed waveforms
extends beyond the domain of the overlapping region. The developed
dictionary learning approach provides physically interpretable results
and offers a powerful tool for additional applications for data
enhancement in earth sciences.
Effectiveness of levosimendan and role of cardiac magnetic resonance in cardiogenic shock due to COVID-19 related lymphocytic myocarditis in the course of viral sepsis
Authors:   Cardiovascular Advanced Cardiac Imaging Unit, “Di Summa – Perrino” Hospital, Brindisi, Italy, Mangini Francesco , Bruno Elvira ,   ICU/Cardiology Unit, “Camberlingo” Hospital, Francavilla Fontana, Brindisi, Italy, Caramia Remo ,   Anesthesiology Department, “Camberlingo” Hospital, Francavilla Fontana, Brindisi, Italy
Published: May 2023

COVID-19 and sepsis pose great challenges to clinicians and growing evidence is demonstrating links between the two conditions. Both can be complicated by acute heart failure. The use of levosimendan in patients with ventricular dysfunction during COVID-19 infection and sepsis has very little evidence. A 46-year-old, hypertensive and obese patient was admitted for severe left ventricular failure and shock during sepsis following a COVID-19 infection. The patient was treated first with norepinephrine, which was partially effective, then with the addition of levosimendan as a continuous 24 hours infusion. Vital signs and echocardiographic systolic performance indices, such as FE, SVi, CI, dP/dT, TAPSE, and tricuspid S-wave velocity, as well as diastolic function, were recorded at access, 12 and 24 hours. After initiation of levosimendan, a rapid improvement in vital signs and systolic and diastolic performance indices was observed, not depending on changes in preload, afterload, and inflammatory status. Blood cultures were negative for the presence of bacteria, thus defining the picture of likely viral sepsis. Cardiac magnetic resonance was determinant, showing a picture of myocarditis sustained by immune processes rather than direct viral injury, which was confirmed by endomyocardial biopsy. In conclusion, this case highlights the efficacy of levosimendan in acute heart failure complicated by shock due to COVID-19-related myocarditis and concomitant sepsis and confirms cardiac magnetic resonance as the gold standard for the diagnosis of myocardial inflammatory disease. To the best of our knowledge, this is the first documented case of effective use of levosimendan in this context.
From recurrent rhabdomyolysis in a young adult to carnitine palmitoyltransferase II deficiency
Authors:   Internal Medicine Department, Santa Maria Maior Hospital Barcelos, Barcelos, Portugal, Marques Cristina , Silva Catarina ,   Internal Medicine Department, Santa Maria Maior Hospital Barcelos, Barcelos, Portugal, Silva Carina ,   Internal Medicine Department, Santa Maria Maior Hospital Barcelos, Barcelos, Portugal
Published: May 2023

Metabolic myopathies are a diverse group of rare genetic disorders associated with recurrent episodes of rhabdomyolysis, induced by triggers such as fever or exercise. In these disorders, the energetic metabolism is compromised resulting in damage of the muscle cells. The diagnosis can be challenging but is essential for the correct treatment. Carnitine palmitoytransferase II (CPT-II) deficiency is the most common long-chain fatty acid oxidation defect, with the adulthood form requiring additional external triggers. The authors present a case of a young-male adult with recurrent episodes of rhabdomyolysis, one of them presented with acute renal failure and acute hepatitis. The diagnostic is demanding, which requires a high level of suspicion. The adequate treatment of these patients improves the muscle function and prevents other episodes of severe rhabdomyolysis.
Utilización del equipo de protección personal e infección por SARS-CoV-2 en trabajadores del sector salud
Authors: Vega Viyuela Alba Maria , Saornil-Pastor Eduardo , Salazar-Ramirez Nidia , Padilla-Mínguez Estibaliz
Published: May 2023

Introducción: Los trabajadores de salud son los primeros en enfrentarse a brotes epidemiológicos, como el causado con el agente infeccioso emergente síndrome agudo respiratorio severo de tipo 2 (SARS-CoV-2). El cumplimiento de las medidas de protección es primordial para evitar el contagio. Para ello se implementó el uso se equipos protección personal (EPP)
Método: Difusión de encuesta voluntaria y anónima entre los empleados de centros sanitarios. (Datos obtenidos desde 6 de noviembre 2020 al 6 febrero de 2021). Se recibieron 443 respuestas validas con las que se evaluó la correcta utilización y acceso al EPP, se midió los casos de enfermedad del coronavirus 2019 (COVID-19) y el efecto de la pandemia en el personal del sector salud.
Diseño del estudio descriptivo, prospectivo y transversal
Resultados: Mayor percepción de los errores cometidos (x2=161,663 con una p=0,000), probabilidad de contagio (x2=81,118 con una p=0,024) y duración síntomas (x2=440,955 con una p=0,001) según la profesión.
Existe relación entre la residencia y nacionalidad del trabajador y la infección por SARS-CoV-2 x2=72,630 con una p=0,020 y una x2=61,247 con una p=0,132. Hay relación entre el número de ítems de EPP usado y la infección por SARS-CoV-2 (x2=38,373 con una p=0,032). Mayor riesgo de contagio según el departamento: residencias (x2=10,223 con una p=0,006), las unidades de pacientes con problemas respiratorios (x2=6,050 con una p=0,049) y las unidades de paliativos (x2=7,795 con una p=0,020).
Conclusiones: Los sanitarios no han estado debidamente protegidos contra la infección por SARS-CoV-2, sobre todo al principio de la pandemia.
O PROGRAMA RESIDÊNCIA PEDAGÓGICA E A FORMAÇÃO DIGITAL DE LICENCIANDOS DAS CIÊNCIAS DA NATUREZA
Authors: Lopes David Santana , Alves Lynn Rosalina Gama , Lira-da-Silva Rejâne Maria
Published: May 2023

A imersão das tecnologias digitais na formação inicial de professores das Ciências da Natureza tornou-se ainda mais complexa desde o início da Pandemia pela Covid-19. Nesse sentido, o presente estudo se propôs a analisar como as tecnologias digitais estão presentes na formação de professores das Ciências da Natureza. Para isso, foram realizadas 15 entrevistas semiestruturadas e a aplicação de um questionário online com professores e estudantes dos subprojetos de Biologia, Química e Física do Programa Residência Pedagógica/Capes (RP/Capes) da Universidade Federal da Bahia (UFBA). Com base nos princípios da Análise Crítica do Discurso foram identificados nos relatos as dificuldades na formação problematizadora com as tecnologias digitais, frente a necessidade de reestruturação das matrizes curriculares das licenciaturas, , além da já enraizada formação instrumentalizadora de futuros docentes. Desta forma, configura-se como essencial a ampliação do fomento aos programas de formação inicial de professores, como o RP, quanto à necessidade de afastar a perspectiva instrumentalizadora que limita o diálogo com as tecnologias, inviabilizando ações atentas às potencialidades com tais espaços digitais.
A CÉLULA É UM OVO-FRITO? UM ESTUDO DE REPRESENTAÇÕES VISUAIS ON-LINE
Authors: Oestreich Laura , Goldschmidt Andréa Inês
Published: May 2023

Este trabalho buscou sinalizar as concepções conceituais das representações imagéticas da célula disponibilizadas on-line, identificando possíveis fragilidades e/ou potencialidades das imagens a fim de estimular uma escolha crítica e fundamentada do professor que utiliza deste recurso em sala de aula. Para tanto, o percurso metodológico se baseou numa abordagem qualitativa de enfoque exploratório, visando compreender o significado das imagens por meio da Gramática do Design Visual. O corpus de análise inicial contou com 2.794 imagens, buscadas no Google Imagens pelas palavras-chave: “biologia celular”, “célula”, “citologia” e “estruturas celulares”. Após as devidas exclusões, o corpus de análise final contou com 1.282 imagens. Os resultados sinalizaram um predomínio de imagens estáticas em comparação às imagens que narravam processos. As imagens de células animais ovoides dominaram os bancos de dados, bem como as células eucariontes. Ainda, os microrganismos tiveram baixa representação imagética. Ao final reiteramos a importância do professor como peça-chave na escolha crítica e fundamentada de imagens para ensinar, a fim de que essas cumpram seu papel pedagógico.
Designing a Grid-Connected Battery Energy Storage System: Case Study of Mongolia
Authors: Sakai Atsumasa
Published: May 2023

This paper highlights lessons from Mongolia on how to design a grid-connected battery energy storage system (BESS) to help accommodate variable renewable energy outputs. The paper suggests how developing countries can address technical design challenges, such as determining storage-capacity size, and regulatory issues to do with ownership, safety, sustainability, and commercial viability. It aims to help governments accelerate BESS solutions and expedite progress toward carbon-neutral societies.
Research on leak monitoring of the primary circuit of a pressurized water reactor based on the 13N coincidence method
Authors: Zhao Yue , Qu Guo , Zhou Jian
Published: May 2023

To assess the characteristics of 13N decay, a monitoring method of the
primary loop leakage rate based on the ?-? coincidence method was proposed.
In this work, sampling and measurement devices were designed, in which NaI
(Tl) crystals were used as coincidence detectors. The Geant4 simulation
method was used to study the relationship between the efficiency e and
capacity V change of different devices, and the eV value under the
corresponding capacity was obtained. According to the value of eV, the
optimal sampling and measurement device was determined, and then the
detection efficiency of the device was calibrated experimentally. Taking the
600 000 kW reactor of Qinshan Phase II as the research object, the lower
limit of detection was discussed. When the sampling point was located in the
fume hood of the control rod drive mechanism, the theoretical lower limit of
the coincidence method was 0.756 Lh-1.
Unusual case of Parkes-Weber syndrome in a patient with spontaneous subarachnoid hemorrhage
Authors: Ilic Jovan , Kostic Aleksandar , Nikolov Vesna , Djordjevic Marija , Radisavljevic Misa , Jelenkovic Boban , Stojanovic Nikola , Aracki-Trenkic Aleksandra
Published: May 2023

Introduction. Parkes-Weber syndrome (PWS) is a complex and rare genetic disease of combined vascular malformations that primarily occur in the extremities and can involve the pelvic blood vessels. In extremely rare cases, the disease is manifested by endocranial and spinal involvement. The treatment of such patients represents a challenge for neurosurgical centers and requires a multidisciplinary approach. Case report. We present the case of a 46-year-old male patient admitted to the emergency department due to spontaneous subarachnoid hemorrhage (SAH), moderate flaccid paraparesis, and urinary incontinence. The patient was previously diagnosed with PWS, while the genetic evaluation proved the RASA1 gene mutation. Furthermore, he experienced a spontaneous SAH and was hospitalized 26 years ago, while six years ago, he underwent a right nephrectomy due to multiple hilar aneurysms of the right renal artery and its branches. Digital subtraction angiography of the endocranium was performed, which detected no aneurysmal dilatations or arteriovenous malformations (AVM). The magnetic resonance imaging recorded spinal intradural AVM in the vertebral levels between T12 and L3, which completely filled the dural sac. After the conservative treatment, there was a significant improvement in the patient?s neurological and clinical condition. Conclusion. To the best of our knowledge, this is the only case report of a patient with PWS who had a spinal intradural AVM and spontaneous SAH without high-output heart failure and with a history of a previous nephrectomy.
Severe mental illness and type 2 diabetes outcomes and complications: a nationwide cohort study
Authors: J Fleetwood Kelly , H Wild Sarah , AM Licence Kirsty , W Mercer Stewart , J Smith Daniel , A Jackson Caroline , Scottish Diabetes Research Network Epidemiology Group the
Published: May 2023

  

OBJECTIVE

To compare cardiovascular and mortality outcomes in people with severe mental illness (SMI) versus no mental illness in a national cohort study of people with type 2 diabetes. 

RESEARCH DESIGN AND METHODS

We included adults diagnosed with type 2 diabetes between 2004 and 2018 from the national Scottish diabetes register, ascertaining history of mental illness from linked psychiatric and general hospital admission records. We identified major cardiovascular disease (CVD) events, all-cause mortality and CVD-specific mortality through record linkage. Using Cox regression, we estimated hazard ratios (HR) for associations between SMI and outcomes, adjusting for baseline sociodemographic and clinical characteristics, including history of CVD, comorbidity, hypertension, high cholesterol, HbA1c, BMI, alcohol use disorder and smoking.

RESULTS

Amongst 259,875 people with type 2 diabetes, 1.0%, 0.5% and 3.0% had schizophrenia, bipolar disorder and major depression, respectively. After adjusting for sociodemographic characteristics, risk of major CVD events was higher in people with schizophrenia (HR 1.22, 95% CI 1.06–1.41), bipolar disorder (HR 1.58, 95% CI 1.33–1.87) and major depression (HR 1.59, 95% CI 1.49–1.70), compared to people without a history of mental illness. SMI was also associated with approximately two-fold increased risk of CVD-specific and all-cause mortality. All associations attenuated following further adjustment for clinical characteristics.

CONCLUSIONS

Among people with diabetes, people with a history of SMI have poorer cardiovascular and mortality outcomes compared to those without mental illness. Whilst the underlying mechanisms are further investigated, effective prevention and management of cardiovascular risk factors is needed in this high-risk group.
Fortalecimiento de las competencias comunicativas del aprendiz SENA – CEDEAGRO
Authors: Cepeda Pardo Adriana
Published: May 2023

Esta investgación aplicada surge de la necesidad de realizar un trabajo que responda a las demandas que persiguen los empleadores del sector productvo en relación con el desarrollo de habilidades blandas como las competencias comunicatvas. Por lo tanto, este estudio tene como objetvo fortalecer las competencias comunicatvas e investgatvas de los aprendices del Centro de Desarrollo Agropecuario y Agroindustrial CEDEAGRO - SENA. Para esto, se implementó una metodología cuanttatva de tpo estudio de caso a una muestra de 53 aprendices; el cual permitó concluir que, los partcipantes presentaban difcultades en habilidades de comunicación verbal y comprensión lectora, impidiéndoles transmitr una idea correctamente y comprender un texto; con la implementación de las diferentes actvidades y talleres enfocadas al fortalecimiento de las habilidades de comunicación verbal, escritura y comprensión lectora, se logró obtener cambios positvos en el desenvolvimiento de los aprendices ante público, la escritura de un documento y la comprensión lectora.
Female Characters in Phaswane Mpe's Welcome to Our Hillbrow and Niq Mhlongo's Dog Eat Dog
Authors: Zewdu Aklilu Dessalegn , Daniel Abiye
Published: May 2023

This article examines two novels by Phaswane Mpe and Niq Mhlongo, Welcome to Our Hillbrow and Dog Eat Dog, by focusing on how they portray post-apartheid South African women and their experiences during and after the fall of apartheid. Set in the early years of South Africa’s democracy, these novels can be read from a feminist perspective, which offers an opportunity to investigate the condition of black South African women and their struggle in the context of the legacies of apartheid and the persisting male domination. The article employs postcolonial feminism as an approach and studies the two novels comparatively to see how the authors depict South African women in the face of double colonization and how they stand up to it. As the analysis indicates, Mpe and Mhlongo have voiced the plight of South African women through female characters that have continued to carry the burden of the legacy of apartheid and the persistence of patriarchy in the post-apartheid era. They have also demonstrated the resilience of women by featuring characters that reject exploitation and seize the opportunities offered by the newly-democratized nation.
Pengembangan Komik Digital Berbasis CTL Untuk Pemahaman Konsep IPA dan Motivasi Belajar Siswa Sekolah Dasar
Authors: Rahayu Ade , Prasetyo Agung Tri , Utomo Cahyo Budi
Published: May 2023

This study is prompted by various discoveries, including the fact that teachers have not used learning media efficiently, resulting in students who do not comprehend the notion of learning and a lack of student interest in the learning process. The goal of this study was to create Contextual Teaching and Learning (CTL) based digital comic media and assess its practicality, efficacy, and students' reactions to it to improve students' conceptual comprehension and motivation in scientific learning. This is a sort of development study. The development model employed is a 4-D model that includes steps for defining, designing, creating, and deploying. The results revealed that digital comic validation was performed based on numerous factors, with the material aspect receiving an average of 3.6 with the Very Valid criterion. Using the Extremely Valid criterion, the aspects of the questions received an average of 3.6. Using the Valid criterion, Display Aspect received an average of 3.46. The final test results following the media application revealed that the average student learning outcomes in the experimental class were greater than those in the control class. The analysis of the findings of students filling out the motivation to learn questionnaire is likewise at a very high level.
Pop Up Book Media to Improve Disaster Literacy in “Kurikulum Merdeka”
Authors: Cahya Risky Dwi , Pambudi Dholina Inang , Febri Romi , Wahid Nurfauzan
Published: May 2023

Understanding by Design (UBD) is a recommended learning model in the independent learning curriculum. The issue in this study is that Indonesia is a country of a million disasters so it is important to have broad insights related to disasters and their mitigation. The reality is that students still lack insight into disasters and their mitigation. The purpose of the study was to improve the disaster literacy of students using the UBD learning model with pop-up book media. Quantitative methods were used in the study. The population in this study was SD N Experimental Padang, West Sumatra which had a sample of 42 students divided into a control class and an experimental class. The result of the application of the UBD model is the result of statistical analysis with a t-test showing that the value of the t coefficient is 19,252 with a df of 20 and a p-value of 0.00. The coefficient is p-value<y= 0.05.  Demikian, it can be concluded that the test rejects H0 or accepts H1.  The test results have a significant influence on UBD's learning model with pop-up book media on increasing student disaster literacy. The conclusion of this study is to use the UBD learning model with pop-up book media to increase disaster literacy in elementary school students.
Case Analysis of Learning Physics in Improving 21st-Century Skills
Authors: Ashel Hazrati , Lestari Wiwit Yuli
Published: May 2023

The government makes various policies to deal with changes in the 21st century, one of which is by implementing the 2013 curriculum. The curriculum that was applied focused on student center approach. Further research needs to be done to determine whether physics learning in SMA/MA follows the 2013 Curriculum and can acquire students with 21st-century skills. This study aims to determine the current quality of Physics learning, problems that occur in Physics learning, and solutions to solve the problems that occur in Physics learning. The research was conducted using a qualitative descriptive method. The research instrument used was a questionnaire google form given to 20 physics teachers and 50 students in senior high school in West Sumatera. In order to obtain further detailed information, three teachers were interviewed. Based on the questionnaire and the results of interviews, it was concluded that the learning of Physics is following the demands of the 2013 Curriculum and can improve the 21st-century skills of students, but it could be more optimal. Therefore, to find a solution to this problem, the researcher recommends developing a project-based and STEM-integrated textbook.
Development of "Love the Motherland" Digital Storybook for Early Childhood
Authors: Harpiyani Reny , Hendriana Benny , Vinayastri Amelia
Published: May 2023

The rapid development of the flow of globalization makes it easier for cultures from abroad to enter Indonesia and makes it possible for future generations to forget their own culture, including early childhood, which is the nation's next generation. Therefore, it is necessary to have a learning media for early childhood instilling the character of love for the homeland, namely through the medium of digital love story books for the homeland. The purpose of this development is to introduce ways to love the homeland and also to instill the character of love for the homeland in children from an early age. This research uses the R&D (Research and Development) method with the ADDIE development model. This digital storybook media was tested by material experts, media experts, teachers, and guardians of PAUD Nusa Indah students. The results of the assessment of media experts were: 90% (very valid), material experts 95% (very valid), teachers and parents 98% (very valid). Based on the results of the assessment, it shows that digital story books are very good as a medium for early childhood learning in instilling the character of love for the homeland.
Comparison of Facebook and Instagram to Assess the Efectiveness of Advertising Channels in Customer Acquisition
Authors: Al-aziz Husein Yusuf , Monalisa Siti
Published: May 2023

The use of social media as a means of marketing is certainly familiar, this happens because of the very competitive market situation, changing trends and increasingly complex customer demands. Facebook and Instagram are platforms that excel in the field of advertising and also interaction between users. However, with the existence of two superior social media, evaluation is certainly needed to find out which social media has a better level of engagement. The purpose of this study is to find out which social media platform is superior in engagement rate. This study used the T test model to compare the engagement rates of the two social media. Based on the results of the study, the use of paid advertising on Facebook social media for 23 days has a better engagement rate compared to Instagram. So it can be concluded that the use of Facebook is more effective in terms of engagement compared to Instagram.
Pengaruh Kepemimpinan Transformasional Kepala Sekolah, Motivasi Kerja, Dan Kedisiplinan Terhadap Pengembangan Karir Guru SD
Authors: Ngadimin Ngadimin , Wuradji Wuradji
Published: May 2023

This study aims to investigate the extent of the effects of principals’ transformational leadership in terms of teachers’ perception, work motivation, and discipline on the career development of elementary school teachers in Godean District, Sleman Regency. This research is a type of non-experimental quantitative approach, The subjects were teachers in the Unit Yandik Godean districts, teachers involved in the study were 173 persons. The descriptive results of the study show that principals’ transformational leadership is in the high category with a mean of 3.44, teachers’ work motivation is 3.46, teachers’ discipline is 3.36, and teachers’ career development is 2.94. The results of the regression analysis show that principals’ transformational leadership has a significant effect of 18,1% (p<0.05) on elementary school teachers’ career development, teachers’ work motivation has a significant effect of 7,9% (p<0.05) on elementary school teachers’ career development, and teachers’ discipline has a significant effect of 8,4% (p<0.05) on elementary school teachers’ career development. The results of the analysis show that principals’ transformational leadership, teachers’ work motivation, and teachers’ discipline as an aggregate have a significant positive effect of 24,8%, indicated by the statistical test showing F = 19,955 (p < 0.05), on the career development of elementary school teachers in Godean District, Sleman Regency, Yogyakarta Special Territory.
Determinan dan Peran Dari Kualitas Sistem Informasi Akuntansi terhadap Kinerja Organisasi Perangkat Daerah
Authors: Maharani Intan Pertiwi , Sofyani Hafiez , Nisa' Fitria Sarifatun
Published: May 2023

Tujuan – Penelitian ini bertujuan untuk menguji determinan dan peran kualitas sistem informasi akuntansi terhadap kinerja pemerintah daerah.Metode – Penelitian ini mengambil sampel Organisasi Perangkat Daerah (OPD) Kota Yogyakarta. Responden dari penelitian ini adalah 90 OPD yang menggunakan dan Sistem Informasi Akuntansi (SIA). Data yang diambil dalam bentuk kuesioner yang mengacu pada skala Likert. Penelitian ini menggunakan analisis uji CMB, statistik deskriptif, uji validitas dan reliabilitas, dan uji hipotesis.Hasil – Hasil studi menunjukkan bahwa pengetahuan akuntansi dan ketersediaan dan fungsi jaringan komunikasi berperan positif dan signifikan terhadap Kualitas SIA. sedangkan untuk ketersediaan dan fungsi hardware dan software tidak ditemukan memiliki pengaruh terhadap kualitas SIA. Selanjutnya, kualitas SIA berperan positif dan signifikan terhadap kinerja OPD.Originalitas – Penelitian ini mendokumentasikan studi empiris tentang determinan kunci dari kualitas SIA dan peran SIA itu sendiri terhadap kinerja OPD yang masih jarang mendapat perhatian akademisi, khususnya di Indonesia.Keterbatasan/Implikasi – Ruang lingkup penelitian masih sedikit, sehingga hasil penelitian ini belum bisa digeneralisasikan untuk penerapan SIA di OPD Indonesia. penelitian selanjutnya bisa memperluas sampel penelitian dan menambahkan teknik wawancara dengan OPD. sehingga hasil penelitian bisa menjadi lebih kuat. Penelitian ini diharapkan  dapat memberikan masukan bagi pemerintah daerah dalam meningkatkan kinerjanya melalui pemberdayaan SIA di OPD.
The Role of The Administrators in Increasing The Motivation to Learn The Yellow Book in Students at The Al-Ihya Islamic Boarding School ‘Ulumaddin Kesugihan Cilacap
Authors: Ulin Nuha Muhammad
Published: May 2023

This study aims to determine the role of administrators in increasing the motivation to learn the yellow book of students at the Al Ihya Islamic Boarding School 'Ulumaddin Kesugihan Cilacap. This research is a type of field research (field research). The approach of this research is qualitative research. With the target of research on the motivation to learn the yellow book of students. Therefore, the subject of this research includes caregivers, administrators, and PPAI students. The method used in obtaining data that can support research, researchers use the method of observation, documentation, and interviews. The steps in data analysis techniques in this study include data reduction, data presentation, and verification and drawing conclusions. From the results of the analysis, the authors can conclude that the management plays a role in increasing the motivation to learn the yellow book of students through guiding the students, explaining everything that is studied in the yellow book and providing motivation both in the recitation process and by exemplifying good behavior in everyday life. Of course, this shows the role of the board in motivating the students to learn the yellow book which then has an influence on the motivation of the students in learning the yellow book.
Science and Kawruh Jiwa of Ki Ageng Suryomentaram’s Perspective
Authors: Rohyati
Published: May 2023

The purpose of this study is to describe the thoughts of a so-called Javanese philosopher, namely Ki Ageng Suryomentaram regarding knowledge and science. These two things are certainly different, but they are often used interchangeably. Therefore, it is necessary to explain their position. Knowledge is a series of things that the subject encounters, is obtained about the object through the five senses,    often called science, is a collection of knowledge that has been systematized so that it is logical, methodical, theoretical, objective, and universal. The research was carried out using a qualitative method with a descriptive method. Data was collected through literature searches and library research related to the concept of Ki Ageng Suryomentaram's perspective of science. The results showed that the knowledge found by Ki Ageng Suryomentaram was in the form of Kawruh Jiwa. Namely, knowledge that puts forward the aspect of taste or "roso" so that humans understand themselves completely. The discovery of the soul of Ki Ageng Suryomentaram cannot be separated from the Javanese worldview, namely the link between theory and praxis which eventually leads to true wisdom as an ideal of living together.
Analysis of Teun A. Van Dijk’s Discourse Model on One Online News in Portal-Islam
Authors: Anjarsari Riana , Nugraha Adiwijaya Satria
Published: May 2023

Submission of information from online to readers has various perceptions on the reader's cognition, especially in the aspect of work plagiarism. Unbalanced media coverage has diversified impacts. This also happened to the news that Afi Nihaya was Accused of Plagiarism from Mita Handayani's account on the Islamic Portal online portal. In addition to the attention of news readers, the emergence of the news as a form of court that occurs in the community. This study aims to deconstruct the unfairness of online towards Afi Nihaya. The method used in this research is descriptive qualitative and using critical discourse analysis of Teun A. Van Dijk. Research data was taken from the Islamic portal about Afi Nihaya Accused of Plagiarism from Mita Handayani's account. The data analysis technique is based on the discourse analysis of Teun A. Van Dijk's model, namely text, social cognition, and social context. The results of this study (1) the text contains the discourse on the facts of plagiarism carried out by Afi Nihaya Faradisa; (2)social cognition/discourse practices that generate ideas and the alignments of journalists are both not in favor of Afi; (3) the social context/sociocultural practice which can be seen from the media's alignment in the resulting news is that they are both not in favor of Afi. Thus, online about Afi Nihaya Faradisa experiences injustice in the attitude and role of the news media, causing a shift in attitudes among readers
La reforma de la escritura china: su romanización
Authors: Pan Lien-Tan
Published: May 2023

Como se sabe, de las actuales escrituras del mundo, la china esla más antigua. Una quinta parte de la población mundial la utiliza cotidianamente, y además de los chinos, numerosas personas del resto del mundo la aprenden.
Giles Chance, China and the Credit Crisis. The Emergence of a New World Order, Singapur, John Wiley & Sons (Asia) Pte. Ltd., 2010, 224 pp.
Authors: Fonseca Fernández Fabricio Antonio
Published: May 2023

Giles Chance, China and the Credit Crisis. The Emergence of a New World Order, Singapur, John Wiley & Sons (Asia) Pte. Ltd., 2010, 224 pp.