bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute Renal Failure and Its Complications, Indications for Emergent Dialysis, and Dialysis Modalities
Authors: Muaddi Luba , Ledgerwood Chelsea , Sheridan Robyn , Dumont Tiffany , Nashar Khaled
Published: May 2022

Acute kidney injury or acute renal failure is commonly observed in the critically ill patient with hemodynamic compromise. Dialysis is frequently used in the intensive care units as part of the critical care management of metabolic derangements fluid status and electrolyte issues. It is imperative that the bedside critical care nurse is able to identify acute kidney injury and is familiar with the modalities used to manage the metabolic consequences of renal failure, particularly important as the bedside nurse is operating the continuous renal replacement machine at the bedside. This article will review the common risks and causes of acute kidney injury in the critically ill patient, indications for conservative management versus initiation of renal replacement therapy, prevention of acute kidney injury, and important consequences of renal failure such as electrolyte disturbances and uremia. We will also briefly touch on specific conditions where acute kidney injury is common such as hepatorenal syndrome, cardiorenal syndrome, rhabdomyolysis, and tumor lysis syndrome.
Improving Helmet CPAP Use During COVID-19 Pandemic
Authors: Privitera Daniele , Mazzone Annamaria , Vailati Paolo , Amato Raffaela , Capsoni Nicolò
Published: May 2022

The aim of this article is to describe the importance of a multidisciplinary team dedicated to noninvasive ventilation training of the emergency department's staff. In our experience, the presence of a medical and nursing “noninvasive ventilation group” made it possible to quickly teach expertise on the management of noninvasive ventilation of COVID-19 patients among emergency department doctors and nurses. This allowed improving a standardized approach regarding the identification and ventilatory assistance of patients with SARS-CoV-2 pneumonia needing ventilatory support, the correct use of the devices, and quick identification and reduction of the complications associated with noninvasive ventilation.

In this article, we would like to encourage the formation of similar working groups in all situations where this is not yet present.
Corneal diameter measurements by 3 optical biometers and their effect on phakic intraocular lens sizing
Authors: Savini Giacomo , Lupardi Enrico , Hoffer Kenneth J. , Aramberri Jaime , Schiano-Lomoriello Domenico
Published: May 2022

Purpose:

To compare phakic intraocular lens size calculations based on corneal diameter (CD) measurements by 3 instruments.

Setting:

G.B. Bietti Foundation I.R.C.C.S., Rome, Italy.

Design:

Retrospective interventional case series.

Methods:

Preoperatively, CD was measured with the Aladdin, IOLMaster 700, and Pentacam AXL Wave. The simulated ICL size was computed by entering CD measurements into the manufacturer's calculator. Postoperatively, vaulting was measured by anterior segment optical coherence tomography. The optimal ICL size (OIS) was calculated and compared with the commercially available OIS (CAOIS).

Results:

54 eyes (29 patients) with the implantable collamer lens (ICL) were enrolled. The mean CD was 12.02 ± 0.36 mm with the Aladdin, 12.35 ± 0.39 mm with the IOLMaster 700, and 12.22 ± 0.41 mm with the Pentacam AXL Wave (P < .0001), with the closest agreement between the Pentacam AXL Wave and IOLMaster 700 (95% limits of agreement: −0.43 to +0.17 mm). Vaulting (mean: 558 ± 261 μm) was within 251 and 1000 μm in 49 eyes (83.3%). The mean difference between the simulated ICL size and OIS ranged between −0.11 ± 0.35 mm and 0.10 ± 0.30 mm (P < .0001), with no statistically significant difference between the IOLMaster 700 and Pentacam AXL Wave. The simulated ICL size was equal to CAOIS in 38 eyes (70.37%) with the Aladdin, 37 eyes (68.52%) with the IOLMaster 700, and 39 eyes (72.22%) with the Pentacam AXL Wave, without any statistically significant difference.

Conclusions:

CD measurements by the 3 devices lead to similar percentages of eyes with an ICL size equal to the OIS. Agreement is closer between the IOLMaster 700 and Pentacam AXL Wave.
Clinical outcomes in a U.S. registration study of a new EDOF intraocular lens with a nondiffractive design
Authors: McCabe Cathleen , Berdahl John , Reiser Harvey , Newsom T. Hunter , Cibik Lisa , Koch Douglas , Lemp-Hull Jessie , Jasti Srichand
Published: May 2022

Purpose:

To evaluate the effectiveness and safety of the DFT015 intraocular lens (IOL) (AcrySof IQ Vivity Extended Vision) compared with an aspheric monofocal control IOL (AcrySof IQ model SN60WF).

Setting:

11 investigation sites in the U.S.

Design:

Prospective randomized controlled clinical study.

Methods:

Patients aged 22 years or older with bilateral cataracts were randomized to receive bilateral implantation of DFT015 or SN60WF. The 4 coprimary effectiveness outcomes (6 months postoperatively) were monocular photopic distance-corrected intermediate visual acuity (DCIVA), monocular photopic corrected distance visual acuity (CDVA), monocular depth of focus (DoF), and the percentage of patients achieving a DCIVA of 0.2 logMAR or better. The mean monocular photopic distance-corrected near visual acuity (DCNVA) was a secondary effectiveness outcome. Safety and patient-reported visual disturbances were evaluated through questionnaires.

Results:

218 patients (435 eyes) completed the study. Compared with SN60WF, DFT015 demonstrated superior mean monocular photopic DCIVA (P < .001), noninferior mean monocular photopic CDVA, and superior mean monocular photopic DCNVA (P < .001) and provided an extended monocular DoF (increase of 0.54 diopters at 0.2 logMAR). With DFT015, 78 first eyes (72.9%) achieved a DCIVA of 0.2 logMAR or better at 6 months. Incidences of ocular serious adverse events and patient-reported most bothersome visual disturbances were low and consistent between groups.

Conclusions:

DFT015 is safe and effective for the visual correction of aphakia, exceeding American National Standards Institute criteria for an extended depth-of-focus IOL by providing superior DCIVA and DCNVA, with comparable CDVA and visual disturbances to the SN60WF monofocal IOL.
Wellness in Physician Assistant Education: Exploring Mindfulness, Well-Being, and Stress
Authors: Hoover Eve B. , Butaney Bhupin , LeLacheur Susan , Straker Howard , Bernard Kari , Coplan Bettie , Carr Candra , Blesse-Hampton Laura , Naidu Amee
Published: May 2022

Purpose

The current study examined stress reduction activities most commonly used by matriculating physician assistant (PA) students to better understand how students are approaching self-care and management of stress. In particular, the study examined levels of mindfulness and well-being to understand how these relate to various stress reduction approaches at the time of matriculation.

Methods

Newly matriculated students at 9 PA programs located across the nation were surveyed (n = 294). Validated survey instruments assessed levels of mindfulness and general well-being. Stress reduction activities were also assessed. Univariate and multivariate analyses were used to examine levels of mindfulness and levels of well-being to see how these relate to various stress reduction approaches.

Results

The survey response rate was 72%. Nearly one-third of respondents (32%) identified meditation as one of their stress reduction activities, and more than half (53%) reported having participated in mindfulness practice at least once in the past year. Sixty-four percent of students reported awareness of mindfulness practices, while only 16% reported frequent practice within the year prior to matriculation. When looking at variables of interest, decentering and psychological flexibility were significant in accounting for student-reported perceived stress and life satisfaction.

Conclusion

PA students are likely receptive to mindfulness-based interventions that have the potential to improve well-being and reduce stress. There is opportunity for programs to incorporate reliable and structured training within curricula that effectively increases levels of mindfulness and, in doing so, can lead to improvement in perceived stress and life satisfaction. Further research may assist educators in the development of strategies to promote student and clinician wellness.
Dual Process Clinical Reasoning Assessment: Quantifying the Qualitative
Authors: Sisson Caroline B. , Waynick Joshua , Gillette Chris
Published: May 2022

Purpose

The objectives of this study were to: (1) describe a standardized clinical reasoning (CR) assessment process for preclinical physician assistant (PA) students; (2) describe student grades on a checklist by comparing clinical faculty members' judgment on a global rating scale (GRS) with judgments made by a faculty panel; and (3) evaluate interrater reliability between individual faculty members' grading and faculty panel grading.

Methods

Three clinical faculty members created a checklist to assess preclinical PA students' CR on a standardized patient assessment. Individual faculty graders and a panel of faculty graders evaluated student performance. Interrater reliability between individual faculty members and the faculty panel was assessed with Cohen's kappa.

Results

The study participants included 88 PA students (n = 88) and 12 faculty evaluators (n = 12). The faculty panel changed 11 grades (12.5%) from individual faculty members. Cohen's kappa indicated substantial agreement (k = 0.698, [95% CI: 0.54-0.85]) between the individual faculty members' grades and the faculty panel's grades.

Conclusions

The process of conducting a comparison of a checklist, the GRS, and a panel review improves the standardization of assessment and reduces grade inflation.
Machine Learning for Vestibular Schwannoma Diagnosis Using Audiometrie Data Alone
Authors: Carey Grace E. , Jacobson Clare E. , Warburton Alyssa N. , Biddle Elliot , Mannarelli Greg , Wilson Michael , Stucken Emily Z.
Published: May 2022

Objective:

The aim of this study is to compare machine learning algorithms and established rule-based evaluations in screening audiograms for the purpose of diagnosing vestibular schwannomas. A secondary aim is to assess the performance of rule-based evaluations for predicting vestibular schwannomas using the largest dataset in the literature.

Study Design:

Retrospective case-control study.

Setting:

Tertiary referral center.

Patients:

Seven hundred sixty seven adult patients with confirmed vestibular schwannoma and a pretreatment audiogram on file and 2000 randomly selected adult controls with audiograms.

Intervention(s):

Audiometric data were analyzed using machine learning algorithms and standard rule-based criteria for defining asymmetric hearing loss.

Main Outcome Measures:

The primary outcome is the ability to identify patients with vestibular schwannomas based on audiometric data alone, using machine learning algorithms and rule-based formulas. The secondary outcome is the application of conventional rule-based formulas to a larger dataset using advanced computational techniques.

Results:

The machine learning algorithms had mildly improved specificity in some fields compared with rule-based evaluations and had similar sensitivity to previous rule-based evaluations in diagnosis of vestibular schwannomas.

Conclusions:

Machine learning algorithms perform similarly to rule-based evaluations in identifying patients with vestibular schwannomas based on audiometric data alone. Performance of established rule-based formulas was consistent with earlier performance metrics, when analyzed using a large dataset.
Workplace Violence and Bullying: You Can Survive
Authors: Powell Suzanne K. , Fink-Samnick Ellen
Published: May 2022

One of biggest challenges facing the health care industry today is workplace violence and bullying. Sadly, this trend has increased so dramatically that The Joint Commission is tracking these trends and has instituted new requirements in 2022. This Editorial describes the trend and suggests methods to mitigate the situation.
Infants With Congenital Muscular Torticollis: Demographic Factors, Clinical Characteristics, and Physical Therapy Episode of Care
Authors: Greve Kelly R. , Sweeney Jane K. , Bailes Amy F. , Van Sant Ann F.
Published: May 2022

Purpose:

To describe demographic factors, baseline characteristics, and physical therapy episodes in infants with congenital muscular torticollis (CMT), examine groups based on physical therapy completion, and identify implications for clinical practice.

Methods:

Retrospective data were extracted from a single-site registry of 445 infants with CMT.

Results:

Most infants were male (57%), Caucasian (63%), and firstborn (50%), with torticollis detected by 3 months old (89%) with a left (51%), mild (72%) CMT presentation. Cervical range of motion (ROM) limitations were greatest in passive lateral flexion and active rotation. Sixty-seven percent of infants completed an episode of physical therapy, 25% completed a partial episode, and 8% did not attend visits following the initial examination. Age at examination, ROM, and muscle function differed significantly between groups.

Conclusions:

Physical therapists may use clinical registry data to inform practice for timing of referral, frequency of care, and clinician training to manage infants with CMT.
A Multifaceted Evaluation of a COVID-19 Contact Tracing Program in King County, Washington
Authors: Hood Julia E. , Kubiak Rachel W. , Avoundjian Tigran , Kern Eli , Fagalde Meaghan , Collins Hannah N. , Meacham Elizabeth , Baldwin Megan , Lechtenberg Richard J. , Bennett Amy , Thibault Christina S. , Stewart Sarah , Duchin Jeffrey S. , Golden Matthew R.
Published: May 2022

Context:

Despite the massive scale of COVID-19 case investigation and contact tracing (CI/CT) programs operating worldwide, the evidence supporting the intervention's public health impact is limited.

Objective:

To evaluate the Public Health—Seattle & King County (PHSKC) CI/CT program, including its reach, timeliness, effect on isolation and quarantine (I&Q) adherence, and potential to mitigate pandemic-related hardships.

Design:

This program evaluation used descriptive statistics to analyze surveillance records, case and contact interviews, referral records, and survey data provided by a sample of cases who had recently ended isolation.

Setting:

The PHSKC is one of the largest governmental local health departments in the United States. It serves more than 2.2 million people who reside in Seattle and 38 other municipalities.

Participants:

King County residents who were diagnosed with COVID-19 between July 2020 and June 2021.

Intervention:

The PHSKC integrated COVID-19 CI/CT with prevention education and service provision.

Results:

The PHSKC CI/CT team interviewed 42 900 cases (82% of cases eligible for CI/CT), a mean of 6.1 days after symptom onset and 3.4 days after SARS-CoV-2 testing. Cases disclosed the names and addresses of 10 817 unique worksites (mean = 0.8/interview) and 11 432 other recently visited locations (mean = 0.5/interview) and provided contact information for 62 987 household members (mean = 2.7/interview) and 14 398 nonhousehold contacts (mean = 0.3/interview). The CI/CT team helped arrange COVID-19 testing for 5650 contacts, facilitated grocery delivery for 7253 households, and referred 9127 households for financial assistance. End of I&Q Survey participants (n = 304, 54% of sampled) reported self-notifying an average of 4 nonhousehold contacts and 69% agreed that the information and referrals provided by the CI/CT team helped them stay in isolation.

Conclusions:

In the 12-month evaluation period, CI/CT reached 42 611 households and identified thousands of exposure venues. The timing of CI/CT relative to infectiousness and difficulty eliciting nonhousehold contacts may have attenuated the intervention's effect. Through promotion of I&Q guidance and services, CI/CT can help mitigate pandemic-related hardships.
Brief Report: Efficacy and Safety of Efavirenz, Raltegravir, and Dolutegravir in HIV-1/TB Coinfection. A Multicenter Retrospective Cohort Study in France
Authors: Kherabi Yousra , de Castro Nathalie , Sellier Pierre-Olivier , Hamet Gwenn , Brun Alexandre , Méchaï Frédéric , Joly Véronique , Yazdanpanah Yazdan , Molina Jean-Michel
Published: May 2022

Background:

There are limited data comparing the efficacy and safety of raltegravir and dolutegravir to that of efavirenz in HIV-1/tuberculosis (TB) coinfected patients.

Methods:

We conducted a 10-year retrospective study in 4 centers in France. We included all HIV-1/tuberculosis coinfected patients starting antiretroviral therapy with a rifampicin-based regimen, with a plasma HIV RNA level (VL) > 1000 copies/mL. The primary endpoint was the proportion of patients with virological success that is, with VL <50 copies/mL at W48 using an Intention-To-Treat analysis, using last-observation-carried-forward to impute missing data. We also assessed antiretroviral therapy safety, analyzing treatment discontinuation for adverse events.

Results:

Between 2010 and 2020, 117 patients were included. Thirty-nine (33.3%) were treated with raltegravir and 2 nucleoside reverse transcriptase inhibitors (NRTIs), 19 (16.2%) with dolutegravir (and 2 NRTIs) and 59 (50.4%) with efavirenz (and 2 NRTIs). At W48, the primary endpoint was achieved in 24 patients (61.5%) in the raltegravir group, in 12 (63.2%) in the dolutegravir group, and in 41 (69.5%) in the efavirenz group using an Intention-To-Treat analysis (P = 0.68). Emergence of drug resistance in patients with virological failure, defined as a VL >50 copies/mL, was observed in 3 patients with efavirenz and one patient with raltegravir. Rate of treatment discontinuation for drug-related adverse events was 10.3%, 10.6%, 16.9% for raltegravir, dolutegravir and efavirenz respectively (P = 0.67).

Conclusions:

In this retrospective cohort study, raltegravir and dolutegravir yielded similar efficacy and safety results to efavirenz for the treatment of HIV-1/TB coinfected patients.
Simulation-based education improves military trainees’ skill performance and self-confidence in tourniquet placement: A randomized controlled trial
Authors: Scalese Ross J. , Issenberg S. Barry , Hackett Matthew , Rodriguez Richard D. , Brotons Angel A. , Gonzalez Marco , Geracci James J. , Schulman Carl I.
Published: May 2022

BACKGROUND

Tactical Combat Casualty Care (TCCC) is the standard of care for stabilization and treatment of military trauma patients. The Department of Defense has mandated that all service members receive role-based TCCC training and certification. Simulation education can increase procedural skills by providing opportunities for deliberate practice in safe, controlled environments. We developed and evaluated the effectiveness of a simulation-based TCCC training intervention to improve participants’ skill performance and self-confidence in tourniquet placement.

METHODS

This study was a single-blinded, randomized trial with waitlist controls. Army Reserve Officers Training Corp cadets from a single training battalion comprised the study population. After randomization and baseline assessment of all participants, group A alone received focused, simulation-based TCCC tourniquet application training. Three months later, all participants underwent repeat testing, and after crossover, the waitlist group B received the same intervention. Two months later, all cadets underwent a third/final assessment. The primary outcome was tourniquet placement proficiency assessed by total score achieved on a standardized eight-item skill checklist. A secondary outcome was self-confidence in tourniquet application skill as judged by participants’ Likert scale ratings.

RESULTS

Forty-three Army Reserve Officers Training Corp cadets completed the study protocol. Participants in both group A (n = 25) and group B (n = 18) demonstrated significantly higher performance from baseline to final assessment at 5 months and 2 months, respectively, following the intervention. Mean total checklist score of the entire study cohort increased significantly from 5.53 (SD = 2.00) at baseline to 7.56 (SD = 1.08) at time 3, a gain of 36.7% (p < 0.001). Both groups rated their self-confidence in tourniquet placement significantly higher following the training.

CONCLUSION

A simulation-based TCCC curriculum resulted in significant, consistent, and sustained improvement in participants’ skill proficiency and self-confidence in tourniquet placement. Participants maintained these gains 2 months to 5 months after initial training.

LEVEL OF EVIDENCE

Therapeutic/care management; Level II.
Paecilomyces cicadae-fermented Radix astragali ameliorate diabetic nephropathy in mice by modulating the gut microbiota
Authors: Zhou Qing , Yang Fang , Li Zhixun , Qu Qingsong , Zhao Chongyan , Liu Xing , Yang Pengshuo , Han Lu , Shi Yanshuang , Shi Xinyuan
Published: May 2022

The occurrence and development of diabetic nephropathy (DN) are closely related to gut microbiota. Paecilomyces cicadae is a medicinal and edible fungus. Radix astragali is a therapeutic material for unifying Chinese Qi. They can delay the occurrence and development of kidney disease. In recent years, solid-state fermentation of edible fungi and traditional Chinese medicine has become a hot issue.

Hypothesis/Gap Statement. We assumed that solid-state fermentation products of R. astragali and Paecilomyces cicadidae (RPF) could ameliorate diabetic nephropathy and modulate gut microbiota composition.

We aimed to study the function and mechanism of the RPF for ameliorating DN in mice.

We investigated the effect of the potential roles of RPF in DN mice and interaction between DN and gut microbiota using animal experiments and gut microbiota measurements.

We found that RPF dramatically reduced urine protein, serum creatinine and blood urea nitrogen in DN mice. Furthermore, RPF ameliorated the physiological condition of DN mice by regulating the abundance of intestinal microbiota such as Ruminococcaceae_UCG-014,

Allobaculum

, Unclassified_f__Lachnospiraceae Alloprevotella and

Bacteroides

.

RPF can ameliorate diabetic nephropathy and modulate gut microbiota composition.
Regional disparities in prescription methamphetamine and amphetamine distribution across the United States in 2019
Authors: Lopera Sarah D. , O’Kane Victoria M. , Goldhirsh Jessica L. , Piper Brian J.
Published: May 2022

Introduction

Methamphetamine is a highly addictive psychostimulant and controlled substance that has detrimental health consequences for chronic users. Amphetamine is a structurally-related stimulant commonly used to treat ADHD, however, it also has a high risk for substance misuse. The objectives of this report were to characterize the regional differences in prescription methamphetamine and amphetamine distribution in the US, and examine potential reasons for variations in distribution.

Methods

Data for prescription methamphetamine and amphetamine distribution was obtained from the US Drug Enforcement Administration’s Automation of Reports and Consolidated Orders System (ARCOS) Retail Drug Summary Report for 2019. Quarterly, state, and regional differences in distributions of the two controlled substances were analyzed and.

Results

The preponderance (97%) of retail drug distribution for both drugs in 2019 were made through pharmacies. In the same year, prescription methamphetamine (+6.8%) and amphetamine (+5.8%) saw increases in drug distribution from Quarter 1 to Quarter 4.. Across the entire US, total per capita drug weight distribution of amphetamine was exactly 4,000 times higher than methamphetamine. Regionally, total per capita drug weight for methamphetamine was highest in the West (32.2% of total distribution) and lowest in the Northeast (17.4%). The total per capita drug weight for amphetamine was highest in the South (37.0% of total distribution) and lowest in the Northeast (19.4%). The ratio between the 90th and 10th percentiles of per capita drug weight by state was 4.39 for methamphetamine and 2.45 for amphetamine. Distribution of methamphetamine only measured 16.1% of its production quota, while distribution of amphetamine measured 54.0% of its production quota.

Discussion

Overall, prescription amphetamine distribution was common while prescription methamphetamine distribution was rare. Regional disparities were also present with lowest distribution of both substances in the Northeast region. The patterns observed in distribution are likely the result of stigmatization, differences in accessibility, and the efforts of initiatives such as the Montana Meth Project. This cycle will likely also change in response to physician recommendation and public opinions surrounding issues for pharmacotherapies for ADHD management.
Features extracted using tensor decomposition reflect the biological features of the temporal patterns of human blood multimodal metabolome
Authors: Fujita Suguru , Karasawa Yasuaki , Hironaka Ken-ichi , Taguchi Y-h. , Kuroda Shinya
Published: May 2022

High-throughput omics technologies have enabled the profiling of entire biological systems. For the biological interpretation of such omics data, two analyses, hypothesis- and data-driven analyses including tensor decomposition, have been used. Both analyses have their own advantages and disadvantages and are mutually complementary; however, a direct comparison of these two analyses for omics data is poorly examined.We applied tensor decomposition (TD) to a dataset representing changes in the concentrations of 562 blood molecules at 14 time points in 20 healthy human subjects after ingestion of 75 g oral glucose. We characterized each molecule by individual dependence (constant/variable) and time dependence (sustained/transient). Three of the four features extracted by TD were characterized by our previous hypothesis-driven study, indicating that TD can extract some of the same features obtained by hypothesis-driven analysis in a non-biased manner. In contrast to the years taken for our previous hypothesis-driven analysis, the data-driven analysis in this study took days, indicating that TD can extract biological features in a non-biased manner without the time-consuming process of hypothesis generation.

Author Summary

For biological interpretation of lage-scale omics data, two analyses, hypothesis-driven analysis and data-driven analysis including tensor decomposition, have been used. These two analyses have their own advantages and disadvantages, and are mutually complementary. However, the direct comparison between these two analyses for omic data is poorly examined. In this study, we applied tensor decomposition to a dataset representing temporal changes in the human 562 blood molecules as data-driven analysis and extracted three features. We have previously analyzed the same data by hypothesis-driven analysis (Fujita et al., 2022). The three features extracted by the tensor decomposition are the same features extracted by the hypothesis-driven analysis, indicating that the tensor decomposition can extract the features in an unbiased manner. Although the same features can be extracted by the tensor decomposition and hypothesis-driven analysis, hypothesis-driven analysis in our earlier study took years (Fujita et al., 2022), while feature extraction by tensor decomposition took only days in this study. Thus, tensor decomposition can extract biological features in a non-biased manner without time-consuming process of hypothesis generation. We propose that tensor decomposition can be the first choice for analysis of omic data.
Harnessing insect olfactory neural circuits for noninvasive detection of human cancer
Authors: Farnum Alexander , Parnas Michael , Apu Ehsanul Hoque , Cox Elyssa , Lefevre Noël , Contag Christopher H. , Saha Debajit
Published: May 2022

There is overwhelming evidence that metabolic processes are altered in cancer cells and these changes are manifested in the volatile organic compound (VOC) composition of exhaled breath. Here, we take a novel approach of an insect olfactory neural circuit-based VOC sensor for cancer detection. We combined anin vivoantennae-attached insect brain with an electrophysiology platform and employed biological neural computation rules of antennal lobe circuitry for data analysis to achieve our goals. Our results demonstrate that three different human oral cancers can be robustly distinguished from each other and from a non-cancer oral cell line by analyzing individual cell culture VOC composition-evoked olfactory neural responses in the insect antennal lobe. By evaluating cancer vs. non-cancer VOC-evoked population neural responses, we show that olfactory neurons’ response-based classification of oral cancer is sensitive and reliable. Moreover, this brain-based cancer detection approach is very fast (detection time ~ 250 ms). We also demonstrate that this cancer detection technique is effective across changing chemical environments mimicking natural conditions. Our brain-based cancer detection system comprises a novel VOC sensing methodology that will spur the development of more forward engineering technologies for noninvasive detection of cancer.
Emergence of the first XAFS/XRF beamline in the Middle East: providing studies of elements and their atomic/electronic structure in pluridisciplinary research fields
Authors: Harfouche Messaoud , Abdellatief Mahmoud , Momani Yazeed , Abbadi Anas , Al Najdawi Mohammad , Al Zoubi Mustafa , Aljamal Basil , Matalgah Salman , Khan Latif U. , Lausi Andrea , Paolucci Giorgio
Published: May 2022

XAFS/XRF is a general-purpose absorption spectroscopy beamline at the Synchrotron-light for Experimental Science and Applications in the Middle East (SESAME), Jordan. Herein, its optical layout is presented along with its powerful capabilities in collecting absorption and fluorescence spectra within a wide energy range (4.7–30 keV). The beamline is equipped with a conventional fixed-exit double-crystal monochromator that allows the collection of an X-ray absorption spectrum within a few minutes in step-by-step mode. An on-the-fly scanning mode will be implemented shortly where the acquisition time will be reduced to less than a minute per scan. The full automation of the beamline allows performing successive measurements under different conditions. The different experimental setups and special features available to users are reported. Examples of XRF and XAFS measurements are presented, showing the performance of the beamline under different standard conditions.
Exploring new belousovite-related zinc and cadmium alkali sulfate halides: synthesis and structural variability
Authors: Borisov Artem S. , Siidra Oleg I. , Charkin Dmitri O. , Zagidullin Karim A. , Burshtynovich Ruslan K. , Vlasenko Natalia S.
Published: May 2022

Fourteen new belousovite-related compounds, AZn(TO4)X (A = K, Rb, Cs, Tl, NH4; T = S, Se; X = Cl, Br, I) have been prepared via melt and evaporation techniques by reacting AX and ZnTO4 either at high temperatures or in hot aqueous solutions. They adopt the layered structure of the belousovite archetype, and constitute a morphotropic series. The apophyllite-type layers in these structures undergo different corrugations, most pronounced in the case of CsZn(SO4)I. In addition, during the study two species unrelated to belousovite, namely Na4Zn(SO4)2Cl2 and Cs2Cd3(SO4)4, were found with framework crystal structures having different topology and belonging to new structure types.
Synthesis and investigation of the thermal properties of [Co(NH3)6][Co(C2O4)3]·3H2O and [Ir(NH3)6][Ir(C2O4)3]
Authors: Filatov Evgeny , Lagunova Varvara , Kochetygov Ilia , Plyusnin Pavel , Kuratieva Natalia , Kostin Gennadiy , Korenev Sergey
Published: May 2022

The complexes [Co(NH3)6][Ir(C2O4)3] and [Ir(NH3)6][Co(C2O4)3]·H2O have previously been synthesized and their thermal properties studied. The [Ir(NH3)6][Ir(C2O4)3] and [Co(NH3)6][Co(C2O4)3]·3H2O complexes considered here are the end members in a series of possible isostructural solid solutions based on the complex salts in the Co–Ir system. Their crystal structures and thermal properties are described in detail, including temperature-dependent in situ X-ray diffraction. During the thermolysis of these compounds, layered metal nanoparticles are formed. Close attention is paid to the details of the [Co(NH3)6][Ir(C2O4)3] synthesis. It has been shown that the formation of this complex salt is temperature dependent; upon heating, a new phase of the K3[Co(NH3)6][Ir(C2O4)3]2·6H2O salt is formed, which incorporates the initial iridium compound into the crystal structure of the double complex salt. The target [Co(NH3)6][Ir(C2O4)3] product is obtained if the synthesis is carried out at room temperature.
Does access to agricultural credit help disaster-affected farming households to invest more on agricultural input?
Authors: Moahid Masaood , Khan Ghulam Dastgir , Bari M.D. Abdul , Yoshida Yuichiro
Published: May 2022

Purpose

Natural calamities impair agricultural households' ability to invest in their farms. Facilitating access to agricultural credit may assist farmers in the face of negative revenue shocks. The aim of this study is to investigate the impact of agricultural credit on the agricultural input expenditure of disaster-affected farmers in Bangladesh.

Design/methodology/approach

The study utilizes data on 2,519 disaster-affected farming households from Bangladesh's Household Income and Expenditure Study (HIES) 2016–2017, which employs a nationwide representative five-year interval survey. Further, propensity score matching (PSM) identification strategy is used to estimate the average treatment effect on the treated (ATET), and Mahalanobis distance matching (MDM) is used for the robustness test. In addition, heterogeneous analysis has been conducted to explore the impact of agricultural credit on different types of farming households.

Findings

The findings reveal that access to agricultural credit has a favorable and significant effect on farm input expenditure for disaster-affected farmers. Therefore, agricultural credit accessibility could be utilized as a policy tool to assist disaster-affected farmers in improving their investment capacity, and hence, agricultural output.

Originality/value

This study, using a quasi-experimental design of access to agricultural credit on agricultural input expenditures of the disaster-affected farming households in coastal areas of Bangladesh to estimate the causal effect.
Board industry expertise and innovation input: evidence on the curvilinear relationship and the moderating effect of CEO
Authors: Sarto Fabrizia , Saggese Sara
Published: May 2022

Purpose

The study empirically investigates whether the board of directors' expertise in the focal firm's industry has implications for innovation input. Additionally, it explores how this relationship is shaped by the CEO's educational level and background in the technology area.

Design/methodology/approach

The article tests the hypothesized relationships through the Arellano–Bond generalized method of moment estimators, proxying innovation input by R&D to total sales. Moreover, it analyses a sample of privately-held Italian medium and large high-tech companies observed over four years by relying on a unique hand-collected dataset.

Findings

The research documents an inverted U-shaped relationship between board industry expertise and innovation input and shows that such curvilinear effect is moderated by the CEO's educational level and technology background. Specifically, while the curvilinear slope is less steep for highly educated CEO, it becomes steeper in the presence of technology trained CEO.

Practical implications

The paper recommends how to shape the board human capital as a meaningful driver of board effectiveness and innovation. Additionally, it calls the managerial attention towards the interaction and the interplay between board industry expertise and CEO education as able to influence the above-mentioned outcome.

Originality/value

While previous studies have focused on the linear and positive effect of board industry expertise on innovation, this research advances current knowledge in innovation management literature by testing the presence of a curvilinear relationship. Moreover, by exploring the moderating effect of CEO education, the paper provides a comprehensive picture on the interplay among board industry expertise, CEO educational training and innovation input.
National innovation efficiency: a DEA-based measurement of OECD countries
Authors: Erdin Ceren , Çağlar Mehmet
Published: May 2022

Purpose

The purpose of this study is to measure and analyze the national innovation efficiency of organisation for economic co-operation and development (OECD) countries. This is to determine to what extent OECD countries efficiently use the elements that enable innovation activities possible in generating innovation outputs.

Design/methodology/approach

An input–output model was constructed to measure efficiency. The inputs and outputs in the research model are the input and output sub-indices of the Global Innovation Index. Data envelopment analysis was used to measure the national innovation efficiency levels of OECD countries.

Findings

The results show that national innovation efficiency is generally high in OECD countries. However, some countries lag behind in innovation efficiency. OECD countries’ ability to create and provide the elements that enable innovation activities is higher than their ability to create innovation outputs. OECD countries have a good innovation environment and a high level of resources, but they should focus on how to create more innovation outputs.

Originality/value

This study presents a measurement of national innovation efficiency of OECD countries which contributes “Innovation Strategy” agenda. The results empirically show that overall innovation indices cannot be the only indicator of the performance of national innovation systems. In this study, an innovation efficiency/performance matrix is constructed to present the relative positions of the countries to help in examining countries’ strengths, weaknesses and potentials based on innovation efficiency and innovation performance simultaneously. This study contributes to the literature by presenting a broader perspective and measurement of national innovation efficiency by taking an extensive number of indicators into account.
Consumer experience co-creation in speciality coffee through social media sharing: its antecedents and consequences
Authors: Silanoi Tongrawee , Meeprom Supawat , Jaratmetakul Porramate
Published: May 2022

Purpose

The present study aims to examine consumers’ happiness experiences for speciality coffee consumption in Thailand by considering the role of consumers’ active participation, sharing of experience and consumer experience co-creation.

Design/methodology/approach

A purposive survey was conducted in speciality coffee shops located in the largest commercial city and industrial development centre in the Northeastern Region of Thailand, Khon Kaen City, which yielded 271 usable and valid responses. The proposed model was evaluated by using a structural equation analysis with a partial least squares technique.

Findings

The results confirmed that consumers’ active participation and sharing of experience affected their experience co-creation, which in turn contributed to the consumers’ happiness experience at the speciality coffee shops.

Originality/value

This study contributes to the consumer experience co-creation and social media literature by proposing a conceptual model for the speciality coffee consumption experience. Furthermore, the study findings contribute to the existing literature by investigating new linkages, such as the role of consumer experience co-creation in a speciality coffee context as a mediating variable of consumer active participation and the sharing of experience with consumers’ happiness experience.
Can intercluster coordination mediate the relationship between supply chain flexibility and humanitarian supply chain performance?
Authors: Kwateng Kwame Owusu , Tetteh Francis Kamewor , Asare Nancy , Manu Derrick
Published: May 2022

Purpose

The occurrence of disaster and crisis is increasing. They are complex as well as challenging for humanitarian organizations (HOs) and societies involved in disaster relief operations. This study examined the nexus between supply chain flexibility (SCF) and humanitarian supply chain performance (HSCP) among HOs with empirical evidence from HOs in Ghana.

Design/methodology/approach

The study employed the quantitative method to explore the interdependencies among the variables. In congruence with this, the study employed the purposive and convenience sampling technique to obtain information from 168 respondents. The analysis was done using SPSS version 23 and Smart PLS version 3.

Findings

The outcome indicates that intercluster coordination (ICC) plays a significant mediating role between SCF and HSCP.

Practical implications

The outcome of the study indicates that a closer and stronger relationship ensures proper channel use among the HOs. This will improve the performance of the supply chain of HOs and their ability to deal with supply chain uncertainties.

Originality/value

The discovery of this study provides empirical support to the resource-based view theory. Thus, practitioners in the humanitarian setting give priority to factors that could enhance flexibility in their supply chain as well as implement coordination strategies to achieve a responsive humanitarian supply chain (HSC) system in the quest to minimize the outcome of disasters.
Determinants of intention to adopt big data and outsourcing among SMEs: organisational and technological factors as moderators
Authors: Iranmanesh Mohammad , Lim Kok Hong , Foroughi Behzad , Hong Meen Chee , Ghobakhloo Morteza
Published: May 2022

Purpose

Present research aims to study the determinants of big data analytics (BDA) adoption intention and outsourcing in the context of small and medium-sized enterprises (SMEs).

Design/methodology/approach

The partial least squares approach was employed to analyse data collected from 187 SMEs.

Findings

The findings indicate that relative advantage, competitive pressure and environmental uncertainty significantly influence SMEs' BDA adoption intention. Top management support moderates the association between the regulatory environment and BDA adoption intention. Furthermore, organisational readiness moderates negatively the association between BDA adoption intention and propensity to outsource BDA.

Practical implications

The findings benefit SMEs' managers/owners in making well-informed decisions in the BDA adoption process.

Originality/value

The majority of the previous research on BDA adoption intention is limited to large corporations. To address the gap on determinant factors of BDA adoption intention among SMEs, the drivers of BDA adoption intention and propensity to outsource were investigated using the technology-organisation-environment model.
Institutional quality and the duration of agri‐food trade flows
Authors: Engemann Helena , Jafari Yaghoob , Heckelei Thomas
Published: May 2022

Recent trade disruptions and their consequences on supply chains show the importance of stable trade relations for exporters' economic planning and importers' supply security. Both instability in trading partners' economic and institutional environment and differences between them are likely to exacerbate these disruptions. We investigate the role of exporters' institutional quality (IQ) and its similarity with importers' IQ in the stability of trade links. We focus on the trade links of agri‐food products exported from sub‐Saharan African (SSA) countries to the European Union (EU‐28) and consider three dimensions of IQ: ‘government selection, monitoring, and replacement’; ‘efficiency of policy formulation and implementation’; and ‘respect of citizens and state for institutions’. Using a discrete‐time duration model, we show that the duration of SSA exports to the EU‐28 increases with higher exporters' IQ and similarity of trading partners' IQ. The strongest impact of exporters' IQ is associated with ‘government selection, monitoring, and replacement’. In terms of the similarity of trading partners, ‘respect of citizens and state for institutions’ has the largest impact on trade durations. Our findings suggest that the improvement of countries' IQ may boost the stability of trade relationships. Moreover, the similarity of IQs between trading partners supports the stability of trade links and should be carefully considered when establishing new trade relations.
JAE, 2021: Report of the Editor‐in‐Chief
Authors: Harvey David
Published: May 2022

Submissions to the journal have decreased since the Covid‐related surge in 2020, but continue their strong international pattern. Our response times continue to meet or exceed our targets, with a few regrettable exceptions, for which our sincere apologies. The JAE's citation impact factor increased again in 2020 to 3.58, though the calculation now includes early view papers, so is not directly comparable with previous years. Our total 2‐year citations continue a strong upward trend. Our sincere thanks are due to our authors and our many reviewers for this performance. Wiley continue to provide a strong publishing platform with our full archive, generating continuing growth in downloads.
Patients with end‐stage renal disease and diabetes had similar survival rates whether they received hemodialysis or peritoneal dialysis
Authors: Xu Feng , Yang Yue , Wu Man , Zhou Wenhua , Wang Dongxue , Cui Wenpeng
Published: May 2022

Background

The survival rate of patients with diabetes mellitus (DM) and end‐stage renal disease (ESRD) undergoing maintenance dialysis, including hemodialysis (HD) and peritoneal dialysis (PD), is markedly lower than that observed in patients with ESRD without DM.

Methods

We used propensity score matching to balance the clinical characteristics of patients from the HD and PD groups. We compared the survival rate between HD or PD, followed by Cox regression analyses accounting for age, Charlson comorbidity index (CCI), body mass index (BMI), and serum albumin levels to examine the outcome influence of dialysis modalities.

Results

During follow‐up, there were 19 (18.1%) and 18 (17.1%) deaths among patients who underwent HD and PD, respectively (P = 0.856). Kaplan–Meier survival analyses showed no significant difference in overall survival between patients in the HD and PD groups. Cox regression analyses stratified based on age, CCI, BMI, and serum albumin demonstrated that the choice of HD over PD did not influence survival.

Conclusions

Regardless of age, CCI, BMI, and albumin level, patients with DM and ESRD had similar survival rates whether they received HD or PD in China. The choice of dialysis modality should be individualized according to patients' physical status and local practices for patients with DM and ESRD.