bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association Between MTHFR C677T Polymorphism and Homocysteine Levels as Risk Factors for Coronary Artery Disease: A Case-Control study
Authors: Amani Saeideh , Mirzajani Ebrahim , Kassaee Seyed Mehrdad , Mahmoudi Minoo , Mirbolouk Fardin
Published: February 2025

Objectives: Coronary artery disease (CAD) is the leading cause of disability and global death. Homocysteine is a major risk factor for CAD. High plasma homocysteine levels are an independent risk factor for this disease. Methylenetetrahydrofolate reductase (MTHFR) is one of the essential enzymes of homocysteine metabolism. In this way, mutations of genes encoding enzyme reduce its activity, which can increase blood homocysteine levels and ultimately raise the risk of CAD. Accordingly, this study aimed to investigate the association between MTHFR C677T polymorphism and homocysteine with CAD disease. Materials and Methods: The present investigation is a case-control study conducted on the patients of Heshmat hospital, Rasht, Iran. The demographic characteristics of 90 patients and 76 controls were obtained by questionnaires and blood samples were collected to evaluate homocysteine levels and gene polymorphism. MTHFR C677T polymorphism and blood homocysteine levels were assessed using amplification refractory mutation system polymerase chain reaction (ARMS-PCR) and ELISA, respectively, and a comparison was made between the two groups. The statistical analysis of the data was performed using SPSS software, version 21. Results: The frequency of C677T polymorphism genotypes in the control and patient groups was not statistically significant (P = 0.384). The highest frequency of genotype in the control (46.1%) and patient (50%) groups was shown in CT. Plasma homocysteine levels were significantly higher in CAD patients than in the control group (P = 0.001). Conclusion: The results of this study showed that the TT genotype of C677T polymorphism has a protective effect on CAD. Although the results obtained for C677T polymorphism are not statistically significant, this genotype had little effect on atherosclerosis. Consequently, the interaction of MTHFR gene polymorphism with CAD may be due to C677T genotype and homocysteine levels in the selected population of Guilan.
Drug-Dependent Mother’s Needs in Childcare: An Integrative Literature Review
Authors: Bagheri Fatemeh , Ramezani Monir , Boskabadi Hassan , Moghri Javad
Published: February 2025

Objectives: Substance abuse is becoming a particularly alarming issue among women and has been a concerning surge in societies. Childcare is a principal part of pediatric preventive healthcare. A robust body of research has linked maternal substance use with less optimal motherhood and childcare. Given the challenges of parenting for mothers with substance use, as well as the existence of a gap in the literature regarding substance use mothers’ needs in childcare, this integrative literature review was performed. This review aimed to explore the parenting needs of drug-dependent women to optimize the long-term health and development of their children. Methods: Electronic searching of Medline, PubMed, Scopus, Cochrane, Embase, Web of Science, SID, and Google Scholar was performed up to October 2024. Inclusion criteria consist of both English and Persian-published studies assessing childcare challenges and needs in drug-abused women. In the long run, 464 studies met the inclusion criteria. The quality of 20 final reports was evaluated by two researchers who extracted data based on the Whittemore and Knafl recommendations. Results: The childcare needs of these mothers were classified into two main categories: Health care & clinical services (primary health care, perinatal health care, home visits, reproductive health care, breastfeeding counseling, exclusive breastfeeding training, family-planning, self-care education, health education, mental health screening, and counseling, educated health providers, healthcare accessibility) and human & social services (parenting skills education, informative interventions, family counseling, psychological counseling, financial support, instrumental support, spiritual support, emotional support, risk behaviors control, social skills education, empower women, create peer communities, support networks, insurance plans). Conclusions: The childcare needs of these mothers were classified into two main categories: health care & clinical services and human & social services. The findings of this research indicate that childcare for mothers affected by opioid use disorder necessitates a multi-disciplinary approach to identify, develop, and address their needs.
Modifying urban planning to promote child health: A scoping review of reviews
Authors: Wallerich Louise , Simos Jean , Cambon Linda
Published: February 2025

Background: Children’s health is shaped by their physical, natural, and socioeconomic environments. The objective of this study is to identify structural urban planning measures that can positively or negatively impact children’s health. Specifically, we aim to explore how urban planning elements, such as housing, neighborhoods, play areas, and green spaces, influence children’s well-being and health outcomes. Methods: We conducted a scoping review in accordance with the method developed by Arksey and O’Malley, Levac and colleagues’ methodology advancement, and the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline. We explored eight databases, restricting our search to reviews, systematic reviews, and meta-analyses that report on structural measures aimed at modifying urban planning to promote child health. Results: A total of 41 studies were identified for inclusion in this review. The thematic analysis identified: i) interventions aimed at modifying streets; ii) interventions aimed at modifying play areas; iii) interventions aimed at modifying contact with nature; iv) interventions aimed at modifying deleterious exposures (exposure to tobacco, exposure to school); and v) housing. The second level of analysis enabled us to identify and evaluate the conditions for implementation and effectiveness. Conclusion: The review highlighted measures that are favorable to children’s health at the level of neighborhood urban planning and questioned the conditions for implementation in a French context.
Assessing parental stress and self-efficacy: A multisite feasibility study of parent-mediated physical activity interventions for children with developmental disabilities
Authors: Columna Luis , McNamarra Scott , Myers Beth A , Dosa Nienke , Barry Ashlyn , Roth Kristi , Ashby Christine E. , Ku Byungmo , Davis Timothy , Borowski Nikkia , Hooper Lisa M.
Published: February 2025

Background: Children with developmental disabilities often face barriers to engaging in physical activity (PA), impacting their health and quality of life. Parent-mediated interventions (PMIs) have shown promise to reduce these barriers, but little research explores online PMIs for parents of children with developmental disabilities. Thus, the purpose of this study was to assess the feasibility and impact of a multi-site collaborative online parent-mediated PA intervention on stress levels and self-efficacy among parents of children with developmental disabilities over a 12-week period. Methods: Participants (n=55) were parents of children with developmental disabilities, randomly assigned to intervention (n=27) or control (n=28) groups. Results: Recruitment rate was 58%, with an 80% retention rate. The feasibility of online delivery was demonstrated, allowing participation from various locations. An analyses of covariance (ANCOVA) with parental sex and education level as covariates revealed no significant interaction effect between group and time for parenting self-efficacy score (PSE), F(1, 104)=0.118, P=0.732, or PSI, F(1, 104)=0.196, P=0.659. The mean PSI difference (pre-post) was -0.38 (CI: -10.57 to 9.80) for the experimental group and 2.64 (CI: -9.61 to 14.91) for the control group, while the mean PSE difference was -4.41 (CI: -29.33 to 20.49) and 4.75 (CI: -23.22 to 32.73), respectively. Conclusion: Future research should explore the integration of hybrid PMIs in conjunction with qualitative measures to facilitate a deeper understanding of the multifaceted factors influencing parental engagement in PA interventions for children with developmental disabilities.
The NOTCH Pathway, a Mysterious Interaction With Viruses
Authors: Mahabadi Mostafa , Karimi Zarchi Ali Akbar , Jonaidi Jafari Nematollah , Esmaeili Gouvarchin Ghaleh Hadi
Published: February 2025

Among the signaling pathways that influence cell fate decisions and developmental processes is NOTCH. This pathway contains four main receptors (NOTCH1 , 2, 3, and 4) and five ligands, which include delta-like ligands (Dll1, Dll3, and Dll4) and Serrate (Jagged)-like ligands (Jagged1 and Jagged2) in mammals, one or more of which are involved in different diseases/infections. Many studies have addressed the importance of the NOTCH pathway in virus-mediated carcinogenesis, and the effect of the NOTCH pathway in regulating immune responses to viral infections is not negligible. The interaction of viral proteins belonging to high-prevalent viruses (e.g., Epstein-Barr virus [EBV], human papillomavirus, hepatitis B/C, and respiratory viral infections) with NOTCH pathway components has been the focus of attention. The present review attempts to provide a more comprehensive picture of the interaction of viruses with the principal NOTCH pathway that is associated with viral-mediated cancers and adaptive immune responses.
The Effect of Liquidity, Profitability, and Dividend on Firm Value: Role of Capital Structure
Authors: Petronila Thio Anastasia , Aprilianti Angel
Published: February 2025

The aim of this research is to examine the effect of profitability, liquidity, and dividend policy on firm value with structure of capital as moderating variable. The research population, property, and real estate firms listed on the Indonesia Stock Exchange between 2018 and 2022. Purposive sampling combined with casewise diagnostics allowed for the selection of 101 observational data points for research samples. Descriptive statistics, multiple linear regression analysis, and moderated regression analysis were used for data analysis. Firm value is estimated by Tobin's Q ratio. The analysis results prove that profitability with return on assets shows a negative significant effect on firm value, liquidity with cash ratio does not affect firm value, and dividend policy with dividend pay-out ratio shows a positive significant effect on firm value. Structure of capital with debt on equity strengthens the effect of liquidity on firm value but does not moderate the effect of profitability and dividend policy on firm value.
The Effect of Environmental Performance, Green Innovation, and Good Corporate Governance on Financial Performance
Authors: Wati Agustina Sulistyo , Latifah Lyna
Published: February 2025

The aim of this research is to analyze the influence of environmental performance, green innovation, and good corporate governance on financial performance. The population used is manufacturing companies listed on the Indonesia Stock Exchange in 2020 - 2022. This research uses a panel data regression model with a population of 495 units. The number of samples used was 109 units selected using the purposive sampling method. This research uses documentation data collection techniques where data is obtained through financial reports, annual reports and company sustainability reports. The results of this research use panel data regression analysis fixed effect model which shows that partially environmental performance, green innovation and good corporate governance have no effect on financial performance. Meanwhile, environmental performance, green innovation and good corporate governance simultaneously influence financial performance.
The Effect of ESG Disclosure on Risk of Financial Distress: Role of Industry Sensitivity
Authors: Liwa Kezia Hertasneng , Daromes Fransiskus Eduardus , Asri Marselinus
Published: February 2025

This study aims to investigate the moderating role of industry sensitivity in the influence of environmental, social, and governance disclosures (ESG disclosure) on financial distress risk. The population used are nonfinancial companies listed on the Indonesia Stock Exchange (IDX) in 2019-2021. The sample collection method chosen is the purposive sampling method. With this sample collection method, 849 companies were added to the sample pool. The type of data used in this study are documentary data in the form of annual financial statements and annual reports of companies that are tested using multiple linear regression analysis subgroup method. The results of this study indicate that simultaneously dan partially, environmental, social, and governance disclosures have a positive and significant influence on Altman score. The higher the Altman score obtained indicates the lower the risk level of a firm’s financial distress. In addition, industry sensitivity regarding environmental issues does not moderate the relationship between environmental, social and governance disclosures on financial distress risk. The implications of this study are to provide an overview and consideration for the company in order to increase awareness and responsiveness to the social and environmental aspects surrounding the company and encourage the company to implement good governance practices. Another implication of this research is to provide input for users of financial statements, especially investors, to pay attention to environment, social, and governance disclosure as a consideration in making investment decisions.
The Impact of Environmental Management System on Firm Value Through Carbon Emission Disclosure and Environmental Performance
Authors: Limang Andrian , Ng Suwandi , Tangke Paulus
Published: February 2025

The purpose of this study was to examine the impact of environmental management systems on firm value through the mechanism of carbon emission disclosure and environmental performance. This study uses secondary data. The data sources in this study are annual reports and sustainability reports of nonfinancial companies listed on the Indonesia Stock Exchange for the period 2019 until 2022. The sample selection was carried out using a purposive sampling method, with a total sample of 32 non-financial companies. This study uses path analysis and statistical tests of linear regression. The results of this study indicate that the environmental management system has a positive and significant effect on carbon emission disclosure. The environmental management system has a positive and significant effect on environmental performance. Carbon emission disclosure and environmental performance have a positive and significant effect on firm value. In addition, the results of the Sobel test show that carbon emission disclosure and environmental performance can mediate the impact of environmental management systems on firm value.
Residential Mobility as a Life Strategy for Youth: An Analysis of Migration Intentions Among Young People
Authors:   Korean Association of Regional Sociology, Kim Ee-Sun
Published: February 2025

This study explores the potential to interpret the regional mobility of today’s youth through the lens of mobility theory as a dimension of life strategy. Traditionally, domestic mobility among young people has been explained in terms of employment, better job opportunities, and the enjoyment of urban culture. However, to adequately explain the diverse patterns and mechanisms of youth mobility in the 2020s, a broader approach is necessary. This research expands upon existing population mobility models by incorporating variables related to the general state of youth life and future prospects, examining how these factors influence migration intentions. The analysis reveals that young people’s negative experiences or perceptions of constraints, in terms of economic conditions, subjective well-being, and the feasibility of future prospects, increase their likelihood of intending to migrate to other regions. These findings suggest that the youth may consider migration to different areas, regardless of their current residence, as a form of life strategy. This study also finds differences between metropolitan and non-metropolitan youth within the youth cohort. While perceptions of life constraints and conditional disadvantage in future realization are common to both cohorts, the variables that are significantly influential are more pronounced in the non-metropolitan group. These findings suggest that population policies related to the migration of young people need to more actively consider both their life prospects and local context.
Türkiye’de sağlık hizmetlerine erişimin teknik etkinlik değerlendirmesi
Authors: Ekinci Gülay , Yılmaztürk Mustafa Hakan
Published: February 2025

Sağlık hizmetlerinde verimlilik değerlendirmeleri, sağlık alanındaki kaynakların (sağlık profesyonelleri, tıbbi ekipmanlar, finansal kaynaklar, sağlık kurumları vb.) sağlık hizmetine dönüşmesinde etkin bir şekilde nasıl kullanıldığı hususunda kanıtlar sunan ve bu kaynakların ihtiyaçlar doğrultusunda optimal şekilde tahsisini sağlanması ile sağlığa erişim ve hakkaniyet açısından oluşabilecek sorunları önleyen bir yaklaşımdır. Bu araştırmanın konusunu Türkiye’de iller düzeyinde sağlık hizmetlerine erişimi gösteren hekime müracaat sayılarına ait teknik etkinlik düzeylerinin memnuniyet ile ilişkilendirilerek ölçülmesi amacıyla yapılmıştır. Araştırma Veri Zarflama Analizi kullanılarak yapılmış, kapasite kullanımına işaret eden hekime ve diş hekimine müracaat sayıları girdi değişkeni, sağlık hizmetlerinden memnuniyet düzeyi çıktı değişkeni olarak tanımlanmıştır. Analizler sabit getiriler (CCR) girdi ve çıktı yönlü modeller kullanılarak gerçekleştirilmiştir. Araştırmadan elde edilen bulgulara göre Türkiye’de illerin ortalama etkinlik skoru 0,703 tespit edilmiş, 81 ilin %2,5’i tam etkin değerlendirilirken %97,5’i etkin bulunmamıştır. Yine bulgulara göre mevcut memnuniyet düzeyinin korunması ya da projekte edilen memnuniyet düzeyine ulaşılabilmesi durumunda kişi başı hekime müracaat sayılarında 0,12-3,19 br., kişi başı diş hekim müracaat sayılarının 0,04-0,23br. arasında azaltılması gerektiği hesaplanmıştır. Toplamda müracaat sayılarından kaynaklı verimsizliğin maliyeti 360 milyon-7,7 milyar arasında değişmekte ve toplam sağlık harcamalarının da %0,059-1,28’e işaret etmektedir.
endeble relación entre Argentina y la Unión Europea: Perspectivas para una agenda renovada
Authors: Pizzi Tatiana , Salman Agostina , Gentiletti Juan
Published: February 2025

La relación entre Argentina y la Unión Europea ha experimentado una importante transformación en el contexto de una reconfiguración geopolítica y económica global. Este artículo examina las oportunidades y desafíos que enfrenta esta relación, centrándose en el rol estratégico de Argentina como proveedor de recursos críticos, como el litio y el hidrógeno verde, en el marco de la búsqueda de autonomía estratégica de la UE. A través de un análisis de la dinámica reciente, incluidas las crisis de suministro desencadenadas por la pandemia y la guerra en Ucrania, se discuten las posibilidades de una agenda renovada que promueva una cooperación más estrecha. Sin embargo, la relación está marcada por tensiones y desafíos, como el proceso de ratificación del acuerdo Mercosur-UE y las exigencias regulatorias impuestas por Bruselas. Este trabajo concluye con la necesidad de una colaboración más efectiva que beneficie tanto a Argentina como a la Unión Europea, explorando formas de superar los obstáculos existentes
contribuciones del turismo médico en la generación de soft power de Corea del Sur (2008 - 2022)
Authors: Catelotti Agostina
Published: February 2025

A lo largo de la historia, los Estados han buscado influenciar positivamente a otros países a través de sus valores, cultura y políticas, un concepto conocido como estrategia de soft power. Corea del Sur ha capitalizado su creciente cultura popular, denominada Hallyu, que emergió en los años noventa y ha ganado reconocimiento a nivel internacional. Este fenómeno ha impulsado el crecimiento del turismo en el país y lo ha llevado a incursionar en el turismo médico, aprovechando su avanzada tecnología en este sector. La convergencia entre el turismo médico y el Hallyu ha consolidado a Corea del Sur como uno de los principales destinos médicos a nivel mundial. Este estudio busca explorar las relaciones entre los actores y políticas involucradas en la promoción del turismo médico, así como su contribución en la estrategia de soft power.
Rumichaca, Darién y Río Bravo, un análisis conceptual de frontera
Authors: Vela Enríquez Amelia
Published: February 2025

Las fronteras no son simples líneas divisorias entre naciones; son espacios de interacción, resistencia y transformación donde convergen múltiples dimensiones sociales, políticas y económicas. Los pasos fronterizos de Rumichaca, en la frontera entre Ecuador y Colombia; el Darién, en la zona que separa Colombia de Panamá; y Río Bravo, entre México y Estados Unidos, son ejemplos de cómo las fronteras funcionan como dispositivos que organizan la movilidad humana. En este artículo, se exploran las dinámicas de estos tres pasos fronterizos de forma análoga desde una perspectiva teórica con una metodología de revisión bibliográfica, abordando el concepto de frontera a la luz de autores como Étienne Balibar, Grimson, Sandro Mezzadra y Brett Neilson, entre otros. Para comenzar, se analiza a la frontera desde concepto histórico y dinámico, para luego adentrarse en su interacción con el Estado-nación y la movilidad humana, elementos esenciales en el análisis contemporáneo de las fronteras. También se analizará cómo las fronteras funcionan como espacios de poder, donde los gobiernos imponen jerarquías y control, pero también como lugares de resistencia y transformación, donde las comunidades desafían las políticas restrictivas. Además, se abordará el tema de la seguridad en el contexto contemporáneo, considerando las implicaciones globales y los desafíos actuales. Finalmente, se examinará cómo la globalización afecta a las familias migrantes, transformando las fronteras en barreras no solo físicas, sino también socio culturales.
Impacto del Título 8 en la política migratoria de México
Authors: Espinosa Ortiz Fabricio
Published: February 2025

En México, las políticas migratorias están organizadas en dos grandes dimensiones, una restrictiva y otra de derechos humanos. La primera se relaciona con la regulación y el control de los flujos migratorios y la segunda con el ejercicio de los derechos humanos, lo que incluye el proceso de integración de los migrantes a la sociedad receptora. Aunque, en los hechos, las políticas migratorias son punitivas y restrictivas contra los migrantes y en su ejecución se violan sus derechos humanos. Este texto aborda el impacto en la política migratoria de México del Título 8, una política que faculta al Departamento de Seguridad Nacional de Estados Unidos para imponer severas sanciones penales a los migrantes que intentan cruzar ilegalmente la frontera. Como resultado de estas estrictas medidas, muchos migrantes se ven obligados a permanecer en México durante un período indefinido, a menudo en condiciones precarias. El texto concluye subrayando la necesidad de desarrollar una agenda binacional que respete los derechos humanos y promueva una migración segura, ordenada y regular, priorizando la dignidad y el bienestar de los migrantes.
Mujeres sobresalientes en la política de la India
Authors: Khan Noorin
Published: February 2025

Este comentario destaca a algunas mujeres sobresalientes en la política de la India, quienes han roto y sobrepasado las barreras erigidas por la sociedad, la religión, la casta y sus propios partidos. Hablamos de cuatro mujeres destacadas; Sonia Gandhi, Nirmala Sitharaman, Behenji Mayawati y Mamata Banerjee. Se destacan una por dinastía, y las otras tres por subir los escalones con su educación, dedicación, determinación y esfuerzos. Todas son diferentes, son excepcionales y para ninguna ha sido fácil establecer su lugar en un ambiente casi 80% dominado por el género masculino, pero ocupan un espacio especial en la política de su país y en el ser de su partido y juegan un rol importante en la formación del gobierno estatal y central.
Research on Terrain Response of the Maintenance Armored Security Vehicle
Authors: Dao Manh Quyen , Tran Duc Thang , Nguyen Thanh , Le Van Duong , Chu Van Dat
Published: February 2025

Armored vehicles used for transporting soldiers, integrated with booms and transforming into maintenance armored security vehicles, are a highly effective solution in situations requiring the lifting and movement of heavy objects over short distances. This article presents the dynamics of a maintenance armored security vehicle capable of holding objects while moving on a random rough road or sinusoidal rough road at various speeds. The research model is unique in that it combines a crane and a truck while moving. The 2D dynamic model in this study considers the elasticity of the suspension system, tires, boom cables, and wind load. Random rough road surfaces and the system of differential motion equations are solved using simulation methods in Matlab/Simulink software. The results of the article demonstrate the ability of maintenance armored security vehicles to respond to terrain conditions while simultaneously holding and moving objects on different road surfaces. The findings of the article provide a basis for evaluating the operational capabilities of maintenance armored security vehicles, aiming to propose technical solutions to minimize load oscillations during vehicle movement.
Potential Anticancer Activity of Ethanol Extract from Garcinia mangostana L. Rind on Human MCF-7 Cells
Authors: IforaIfora IforaIfora , Murdiyah Putri Isaura , Agustina Endang
Published: February 2025

Breast cancer remains a significant
global health issue, driving the need for therapies
that are both safer and more effective. Recent
research has concentrated on natural substances as
potentialalternatives to conventional anticancer or
adjuvant chemotherapy. The purpose of the study
was to assess mangosteen rind extract cytotoxic
effects on MCF-7 breast cancer cells. The MTT test
was utilized to evaluate the cytotoxic effects of
mangosteen rind extract (MRE) on MCF-7 breast
cancer cells. A microplate reader set to 570 nm
wavelength was used to analyze the test findings.
Both MRE and doxorubicin (Dox) demonstrated
concentration-dependent cytotoxic effects
according to the MTT assay with IC50 values of
19.2 µg/mL and 1.1 µg/mL on MCF-7 cells,
respectively.This study suggests that MRE could
serve as a promising source of natural anticancer
compounds, increasing the likelihood of creating
innovative treatments for breast cancer in the
future.
Examining the Antioxidant Properties of Avaleha Formulations in Brihat-Trayi: A Critical Analysis of their Constituents' Rasayana Guna
Authors: Siddhpura Dr.Bhavisha , Khatri Dr. Vinita
Published: February 2025

Humans, due to their tremendous intellectual
abilities are on way at par from and this is the most
developed and sophisticated living creature on
earth. They are step ahead, in true sense, desires not
only to live, but to live a long & disease-free life as
far as possible. The ancient revered Acharyas
achieved the aims before thousands of years ago, in
the means of Rasayana which not only helped to
attain longer but healthier life & also prevent
diseases. Out of all Rasayana formulations, most of
them are Avalehas. In Ayurveda there is a special
branch of pharmaceutics called as Bhaishajya
Kalpana dealing with formulations of mainly herbal
medicines, which are basically two types i.e.,
primary and secondary formulations. Avaleha is the
most popular secondary Kalpana (dosage form)
which has been employed in various disorders and
these products are gaining its importance due to its
easy administration, palatability, longer shelf life
and considering as Ayurveda’snutraceutical. It is a
semisolid preparation made from herbal drugs,
prepared in decoction, expressed juices of different
herbs other liquid etc. by adding sweetening agents
like jaggery, sugar & added honey. Here an attempt
is made to collect, analyze &discuss all different
Avaleha formulations and its ingredients for
RasayanaGuna (Antioxidant property) which is
mentioned in Brihat-trayi.
Snacking Patterns and Their Impact on Dental Caries-A Short Communication
Authors: Dr.A.Sidhesh Dr.A.Sidhesh , Dr.K.Rajeswary Dr.K.Rajeswary , Dr.B.Ravisankar Dr.B.Ravisankar , Dr.Kalaivani.S Dr.Kalaivani.S , Dr.P.Sivapriya Dr.P.Sivapriya
Published: February 2025

Snacking patterns significantly influence the risk of
dental caries, a prevalent oral health issue
worldwide. This short communication explores the
relationship between snacking frequency, snack
types, and their impact on oral health. Frequent
consumption of sugary and starchy snacks provides
a continuous substrate for oral bacteria, leading to
acid production and enamel demineralization,
which are primary factors in caries formation.
Additionally, the timing of snacks and inadequate
oral hygiene practices exacerbate the risk, as
prolonged exposure to cariogenic substances
increases the likelihood of tooth decay. The role of
non-cariogenic snacks, such as fruits, nuts, and
dairy products, is also discussed as a potential
preventive measure. This study emphasizes the
need for increased awareness about healthy
snacking habits and the importance of oral hygiene
to mitigate the impact of dietary patterns on dental
caries. Targeted public health interventions are
essential to promote better oral health outcomes
across diverse populations.
Formulation Development and Evaluation of Anti-Aging Vitamin E Face Serum
Authors: Hafizuddin Chishti Nahid Anjum , Shaikh ZohebZaheer , Dnyaneshwar Patil Nikita , Gajanan Saundarkar Aditi
Published: February 2025

Vitamin E serums are concentrated
skincare products that provide targeted treatments
for skin concerns through the antioxidant properties
of vitamin E. These lightweight formulations
penetrate deep into the skin, delivering active
ingredients more effectively than traditional
creams. Specifically formulated to address issues
such as anti-aging, hydration, brightening, and skin
repair, vitamin E neutralizes free radicals and
reduces oxidative stress that causes premature
aging and damage. Vitamin E serums also support
cellular renewal, improve elasticity, and shield the
skin from environmental aggressors. This study
focuses on the formulation, evaluation, and
stability of a vitamin E-based face serum,
emphasizing its role in skincare. The serum was
prepared as an oil-in-water (o/w) emulsion using
key ingredients such as aloe vera gel, olive oil,
vitamin E, glycerin, coconut oil, and Tween 20.
The oil phase, containing olive oil, vitamin E, and
coconut oil, was mixed uniformly and added
dropwise to the aqueous phase of aloe vera gel,
glycerin, and distilled water under mechanical
vibration at 2500 rpm. Evaluations revealed a pale
green, smooth,homogenous serum with a pH of 6.4,
making it suitable for the skin’s natural acidic
range. Spreadability was measured at 5-6 cm, while
viscosity was determined to be 13759 Pascal,
ensuring optimalconsistency for topicalapplication.
Microbial examination confirmed the product was
free from contamination, and stability studies
conducted under various conditions (3-5°C, 25°C
RH-60%, and 40°C RH-75%) showed no
significant changes in physical properties or phase
separation. These findings demonstrate that the
vitamin E serum is stable, effective, and safe,
offering hydration, antioxidant protection, and
enhanced skin texture, making it a valuable
addition to skincare routines.
Role of Rajswala Paricharya on Aartavdushti W.S.R. to Menstrual Disorders A Holistic Approach.
Authors: A. Patil Dr. Veena , K. Agawane Dr. Umesh , Manohar Devane Dr. Priti
Published: February 2025

In Ayurveda, "RajaswalaParicharya" refers to the
specific lifestyle guidelines designed for women
during menstruation (Rajaswala). This term
consists of various practices and recommendations
aimed at supporting women's health and well-being
during their menstrual cycle. Unfortunately, it has
been observed that the RajaswalaParicharya is
neither being publicized nor followed by the
women in today era. As a result, there is need to
educate the females, regarding the
RajaswalaParicharya (ways of living)
recommended by Ayurveda to keep the Dosha in
balance, which maintains health. Ayurveda advises
women to adhere to "Paricharya" conduct that
should be followed at various stages of life, such as
Rajaswala, Garbhini, and Sutika, in order to
improve their health and quality of life. The
RajaswalaParicharya is the one that receives the
least attention. This subject was chosen because it
was noted that modern science has described
fatigue and lower abdomen pain as having an
impact on the menstrual cycle and its related
symptoms, although Ayurveda has not specified
such symptoms. To achieve conception Acharya
Susrutha has described four essential factors for
fertility, Ritu, Kshetra, Ambu, Beeja[1]The females
took part greater role in the conception because
these four factors are related to them. Ayurveda
gives prime importance to preventive aspects and
elaborates "Rajaswalacharya" or the care during
menstrual cycles and during menarche in a female
to prevent and cure gynaecological disorders. Due
to high mental pressure of because of work load,
family stress, competitive behavior in every place,
more expectations. lead to stressful lifestyle.
Ayurvedic Strategies for Effectively Managing Contact Dermatitis: A Single Case Study.”
Authors: Ojha Dr. Shweta , Joshi Dr. Prakash , Wane Dr. Yogesh , Singh Baghel Dr. Akhand
Published: February 2025

In Ayurveda, the term "Kushtha" encompasses a
range of skin diseases. The Vrihattrayi classify
Kushtha as one of the Ashtamahagada due to its
chronic nature, recurrence, and the challenges it
presents in treatment. Among these, Vicharchika is
a specific skin condition characterized by clinical
features described by Charaka, including intense
itching, reddish-brown maculopapular lesions, and
serous discharge. These symptoms significantly
disrupt sleep and daily life. Notably, Vicharchika
closely resembles eczema in its causes, symptoms,
and overall manifestation, highlighting its
relevance in both traditional and modern
dermatological contexts. Contact dermatitis is a
prevalent skin condition characterized by rashes
resulting from exposure to chemical or physical
irritants, allergens, or sunlight. The initial contact
with the irritant triggers an immune response, while
repeated exposure causes a T-cell-mediated
reaction, leading to skin inflammation.
Conventional treatments focus on identifying and
avoiding the irritant, combined with the application
of topical steroids. However, these approaches
provide only temporary relief and often fail to
prevent the progression of chronic contact
dermatitis. This condition is associated with
Vicharchika Kushtha. This case report discusses a
26-year-old Male diagnosed with contact
dermatitis, presenting with red, severe itching,
oozing rashes, and a burning sensation. The patient
underwent Ayurvedic treatment for two months,
during which the severity of the disease was
monitored through clinical symptoms and
photographic documentation of the lesions. The
results showed a significant reduction in symptoms,
demonstrating the effectiveness of the Ayurvedic
approach.
A várzea como refúgio
Authors: Vecchio Pollyanna de Mattos Moura , Oliveira Luiz Henrique Silva de
Published: February 2025

In many Brazilian cities, lowland fields (“várzea”) and amateur football clubs appear to fill the gap in socialization and leisure in areas where public policies are absent. Our hypothesis is that, by listening to the life narratives of different characters from the várzea, it is possible to connect the common points of these voices and bring out the interdiscourse capable of highlighting the knowledge and imaginaries of these subjects about the role and evolution of football in the capital of Minas Gerais. We used spontaneous interviews and theoretical tools from French Discourse Analysis. So, in this study, we interviewed three characters from Belo Horizonte's várzea football from different generations (a 29-year-old participant, a 69-year-old participant and another 72-year-old participant) and we analyzed how the socio-discursive imaginary of amateur football as a “refuge” from hostile environments appears in the interdiscourse that permeates the three life narratives.
Regulação dos direitos de transmissão de futebol
Authors: Santos Anderson David Gomes dos
Published: February 2025

This is a doctoral research report whose objective was to establish criteria for the regulation of football broadcasting. For this, we present case studies on how Brazil, Argentina, Mexico, Uruguay, Portugal and Spain regulated the transmission of sporting events from 2001 to 2020. To achieve the objectives, this paper took the Political Economy of Communication and Culture as a theoretical-methodological basis, in order to present a qualitative research with a critical historical-descriptive profile that used bibliographical research and comparative study as technical procedures, correlating the cases found to seek valid equivalences and analysis scales. As a source of data collection, documentary research was used. It is concluded that it is necessary to renew the regulatory frameworks on the transmission of football matches, in order to consider it as a content of social interest, therefore, with some matches having to be transmitted in a free and live broadcasting service.
Gagliano Neto
Authors: Leal Daniel , Mesquita Giovana
Published: February 2025

The article presents a historical review of the trajectory of “speaker” Gagliano Neto, the first Brazilian radio professional to narrate a World Cup, in 1938, straight from France. The work starts from a bibliographic survey and a documental research at the Hemeroteca Digital Brasileira to analyze the construction of the figure of Gagliano in the national newspapers of the 1930s. The method used to process the 50 occurrences found in 16 newspapers, between 1930 and 1939, was the Content Analysis, from which it was possible to identify a profile about the character created around the figure of Gagliano. This research also explores the form of radio transmission in the early days of this means of communication in Brazil, always focusing on Gagliano, who was a pioneer, aroused admiration and anger, and, on some occasions, was the most heard voice in the country. Despite everything, Gagliano is still a little explored name in the communicational bibliography.
Pemanfaatan Media Sosial TikTok sebagai Media Promosi untuk Pengenalan Industri Kuliner di Yogyakarta melalui Akun TikTok @makanandiyogya
Authors: Putra Harish Maulana , Fajri Choirul
Published: February 2025

Masa pandemi sudah berakhir namun banyak pelaku usaha kuliner maupun pelaku umkm yang masih belum bangkit dari keterpurukan pada saat pandemic Covid-19 di Yogyakarta. Usaha yang dapat dilakukan oleh para pelaku umkm maupun pengusaha kuliner yaitu adalah memasarkan produk dan mengenalkan produk mereka melalui media sosial. Berdasarkan hal ini, media sosial tiktok berpotensi sebagai media promosi yang efisien pada cara memasarkan produk umkm di Daerah Istimewa Yogyakarta. Berikut salah satu akun Tiktok yang memiliki konten sebagai media promosi adalah akun @makanandiyogya. Metodologi yang digunakan adalah Paradigma konstruktivis memiliki tujuan untuk memperolah pengertian, rekontruksi penelitian kualitatif sehingga mendapatkan hasil pengertian yang mendalam dari individu maupun public. Tiktok menjadi media pemasaran yang singkat dan Indonesia menjadi pengguna aplikasi Tiktok terbesar, aplikasi ini mudah untuk digunakan dalam semua kalangan yang berupa didalam dapat mengenai perkembangan trend, dipengaruhi oleh selebriti, Tiktok juga menjadi suatu bentuk pemasaran promosi yang menarik.
Analisis Resepsi Penonton Mengenai Isu Kesehatan Mental pada Film “Sleep Call”
Authors: Arsy Fadhilah Samudra , Saifuddin Windri
Published: February 2025

Penelitian ini ingin melihat tentang bagaimana penerimaan penonton dewasa pada film “Sleep Call” terhadap isu kesehatan mental. Film menjadi salah satu media komunikasi massa yang penting untuk menceritakan peristiwa atau isu sosial yang terjadi dalam kehidupan sehari-hari. tujuan penelitian ini untuk mengetahui penerimaan penonton dewasa terhadap isu kesehatan mental dalam film ''Sleep Call''. Penelitian ini merupakan jenis penelitian kualitatif deskriptif. Penelitian ini secara spesifik lebih diarahkan pada penggunaan metode analisis resepsi, hal ini bertujuan untuk menjawab pertanyaan bagaimana penonton pada penelitian ini menerima sebuah pesan dari media dan dimaknai berdasarkan latar belakang, sosial, dan budaya yang berbeda.
Strategi Corporate Societal Marketing (CSR) Blibli Tiket Action dalam Program Cinta Bumi
Authors: Angkawibawa Harla Nathalya , Elkezia Natasha , Wempi J.A
Published: February 2025

The Cinta Bumi program is part of Blibli's Tiket Action CSR initiative, serving as a tangible action towards sustainability aligned with the Sustainable Development Goals (SDGs). This study applies the Preparation, Engagement, and Perpetuation (PEP) model to explore and analyze the strategies behind the Cinta Bumi program and assess the sustainability strategies implemented by Blibli Tiket Action. The study utilizes a qualitative approach with data collection techniques such as interviews, literature reviews, and document analysis. The research findings indicate that Blibli Tiket Action's implementation of the PEP model has successfully delivered positive impacts, evidenced by the increased recycling of waste and the conversion of used packaging into tree seedlings, as observed through the growing public participation in the Packaging Take Back Program over the years. The study reveals two key findings: effective communication strategies are crucial in delivering information, and many companies in Indonesia implement SDG programs with limited funding, leading to less than optimal results.
Perancangan Prototipe Antarmuka Pengguna pada Aplikasi E-Commerce Pertanian Berbasis Mobile
Authors: Prasetyo Diaz Agil , Oxaveria Carissa Xyla , Aulia Shinta , Richardo Nicko , Saputra Muhammad Reynaldi Dwi , Ningsih Rahmi Yulia , Pratiwi Chairani Putri
Published: February 2025

The use of e-commerce applications in the agricultural sector has not been optimized due to farmers' low understanding of technology and a less user-friendly interface design. This research aims to design a prototype mobile-based e-commerce application interface that suits the needs of farmers. The Design Thinking method is used to understand user needs and develop intuitive solutions. The results showed a friendly interface design for farmers with low digital literacy, thus supporting the adoption of e-commerce applications in the agricultural sector. This research contributes to the increased utilization of technology in the distribution of farm produce and helps improve the welfare of farmers.
Evaluasi Tatakelola TI Menggunakan Framework COBIT 2019 dan Capability Maturity Model Integration (CMMI)
Authors: Akbar M. Dwi Aulia , Panjaitan Erwin Setiawan
Published: February 2025

Universitas Islam Negeri Sumatera Utara (UIN-SU) Medan memiliki tanggung jawab dalam pengelolaan dan keamanan teknologi informasi (TI). Namun, hasil wawancara dengan Kepala PUSTIPADA UIN-SU Medan mengungkapkan beberapa permasalahan, seperti kurangnya perencanaan strategis, ketiadaan visi jangka panjang, keterbatasan sumber daya, kekurangan staf yang kompeten dalam pengelolaan TI, dan belum dilakukannya audit. Untuk mengatasi masalah tersebut, dilakukan evaluasi kapabilitas tata kelola TI menggunakan framework COBIT 2019 dan Capability Maturity Model Integration (CMMI) guna mengukur tingkat kematangan organisasi. Hasil penelitian menunjukkan domain prioritas MEA03 (Managed Compliance with External Requirements) memperoleh nilai 100. Berdasarkan CMMI, domain MEA03 mencapai tingkat kematangan 100% dan berada pada capability level Fully Achieved (85–100%). Dengan demikian, capability level objective process MEA03 telah mencapai level 5 dan status audit dinyatakan tercapai.
Scelta del foro e competenza territoriale per le controversie relative a un trust (Trib. Monza, 30 maggio 2024)
Authors: Galanti Lucilla
Published: February 2025

Massima
Ove le parti abbiano convenuto nell’atto istitutivo la competenza territoriale di un’autorità giudiziaria a dirimere le controversie relative a un trust, la competenza spetta a questa autorità giurisdizionale ed è quindi fondata l’eccezione preliminare di incompetenza territoriale del diverso giudice adito.
Azione revocatoria dell’atto istitutivo di trust e inefficacia “derivata” dell’atto dispositivo (Trib. Foggia, 20 maggio 2024)
Authors: Galanti Lucilla
Published: February 2025

Tesi
L’atto istitutivo di trust può essere oggetto di un’azione revocatoria?
L’autore solleva alcune perplessità rispetto alla soluzione positiva raggiunta dal Tribunale di Foggia. Non solo sulla base di una ragione sistematica di ordine sostanziale, e cioè riprendendo la qualificazione dell’atto istitutivo come atto sostanzialmente “neutro”, ma anche da un punto di vista processuale, entro il quale la revocabilità dell’atto istitutivo pone problemi sia in riferimento al rapporto tra azioni, sia rispetto alla questione di legittimazione, come del resto incidentalmente prospettato, di recente, anche dalla Suprema Corte.
The author’s view
Can the trust deed be subject to a revocation claim?
The author raises some concerns regarding the positive solution reached by the Court of Foggia. These concerns are not only based on a systematic substantive rationale, specifically revisiting the qualification of the trust deed as a “neutral” act, but also from a procedural perspective. Within this framework, the revocability of the trust deed poses issues both in relation to the relationship between legal actions and with respect to the matter of standing, as recently pointed out – incidentally – also by the Supreme Court.
Efektivitas Akupresur Terhadap Penurunan Nyeri Dismenore
Authors: Wardani Frisca Desma Ayu Kusuma , Fitri Windari
Published: February 2025

Berdasarkan angka kejadian nyeri haid di Indonesia yaitu 54,89%, setengah dari remaja usia 10-24 tahun di Indonesia dengan presentase dismenore sebanyak 64,25% yang terdiri dari dismenore primer sebanyak 54,88% dan 9,36% dismenore sekunder. Meskipun dismenore merupakan keluhan yang sangat umum terjadi di kalangan wanita, namun ternyata banyak dari mereka yang tidak mengunjungi dokter atau bidan saat mengalami kondisi ini. Sekitar 30-70% Wanita remaja cenderung mengatasi disemenore dengan mengonsumsi obat penghilang rasa nyeri yang dijual bebas. Tujuan penelitian ini adalah untuk menganalisis efektivitas terapi akupresur terhadap penurunan nyeri dismenore pada Wanita remaja. Metode penelitian yang digunakan adalah eksperimental dengan pendekatan one group pretest-posttest design. Jumlah populasi sebanyak 140 orang siswi SMA yang sedang menstruasi, kemudian besar sampel ditentukan dengan rumus Slovin dan didapatkan sampel sebesar 59 orang. Selanjutnya digunakan teknik pengambilan sampel dengan purposive sampling sehingga didapatkan sampel dalam penelitian ini sebanyak 15 orang. Hasil penelitian didapatkan bahwa akupresur efektif dalam menurunkan nyeri dismenore dengan nilai signifikansi 0,000. Metode ini menawarkan alternatif non-farmakologis yang dapat diakses dan diterima dengan baik oleh banyak wanita. Sehingga akupresur dapat dijadikan salah satu pilihan dalam manajemen nyeri dismenore, terutama bagi mereka yang ingin menghindari penggunaan obat-obatan.