bluuebunny/crossref_metadata_2025 huggingface dataset:
The Silent Majority: Understanding and Supporting Access and Inclusion for People with Disabilities Living in Predominantly Low-Resource Communities
Authors: Rimmer James H. , Quach Phuong T. M. , Ward Stephanie , Young Hui-Ju , Singh Harshvardhan , Lai Byron
Published: December 2023

People with disabilities are often isolated from their community due to issues with accessibility and inclusion, which are worse in low-resource communities. Creating meaningful change will require an understanding of strategies that work at a community-wide level to foster community engagement among people with disabilities. This study utilized a qualitative grounded theory approach to identify barriers and facilitators of community access and inclusion of people with disabilities from the perspectives of 12 neighborhood presidents of low-resource areas within the state of Alabama in the United States. Four themes were identified: (1) community engagement is a process from accessibility to inclusion; (2) knowledge supports people’s needs and empowers systemic changes to policies and laws; (3) neighborhood resources beget further resources; and (4) change necessitates benevolent leadership. Based on these themes, we generated a substantive theory called the Neighborhood Engagement Theory, which health professionals can utilize to support neighborhood presidents in creating systemic change for people with disabilities.
Estimation of Carbon Stocks of Birch Forests on Abandoned Arable Lands in the Cis-Ural Using Unmanned Aerial Vehicle-Mounted LiDAR Camera
Authors: Fedorov Nikolay , Bikbaev Ilnur , Shirokikh Pavel , Zhigunova Svetlana , Tuktamyshev Ilshat , Mikhaylenko Oksana , Martynenko Vasiliy , Kulagin Aleksey , Giniyatullin Raphak , Urazgildin Ruslan , Komissarov Mikhail , Belan Larisa
Published: December 2023

Currently, studies investigating the carbon balance in forest ecosystems are particularly relevant due to the global increase in CO2 content in the atmosphere. Due to natural reforestation over the past 25–30 years, birch (Betula pendula Roth.) forests were extensively grown and established on abandoned agricultural lands in Bashkir Cis-Ural (Republic of Bashkortostan, Russia). The significant positive aspect of reforestation on fallow lands is the carbon sequestration that takes place in the tree phytomass, especially at the growth stage of stand formation. The aim of this article is to test the approach of using a UAV-mounted LiDAR camera to estimate the phytomass and carbon stocks in different-aged birch forests growing on abandoned arable lands in Bashkir Cis-Ural. The methodology was developed using 28 sample plots, where the LiDAR survey was performed using a DJI Matrice 300 RTK UAV. Simultaneously, the stand characteristics and phytomass of stem wood were also estimated, using traditional methods in the field of forest science. The regression equations of phytomass dependence on stand characteristics at different stages of reforestation were constructed using data obtained from LiDAR imagery. It was shown that the above-ground tree biomass could be precisely estimated using the index obtained by multiplying the number of trees and their average height. A comparison of the data obtained using traditional and LiDAR survey methods found that the accuracy of the latter increased in conjunction with stand density. The accuracy of estimation ranged from 0.2 to 6.8% in birch forests aged 20 years and over. To calculate carbon stocks of the above-ground tree stands, the use of regional conversion coefficients is suggested, which could also be applied for the estimation of carbon content in trunk wood and leaves. An equation for the calculation of above-ground biomass carbon stocks of birch forests on abandoned arable lands is proposed.
Analysis of Flow Field Characteristics of the Propane Jet Combustion Flame
Authors: Li Shengnan , Guo Jingjing , Chi Zheng , Zhao Bo , Zhao Shuai
Published: December 2023

In order to effectively prevent fire accidents and improve fire management capability, this paper describes the independent designs and builds of an experimental low-cost particle image velocimetry platform for a propane jet combustion flame using traditional mutual correlation theory. The particle image velocimetry (PIV) algorithm is written based on MATLAB software, allowing it to realise image preprocessing, multi-level grid window deformation inter-correlation calculations, and other functions. Fluid flow velocity and vorticity are used as entry points to study the flame combustion mechanism. The air flow field and vorticity above the propane jet flame are analysed. The results show that, from the level of fluid flow velocity, the maximum fluid flow velocity in the test area does not exceed 0.23 m/s, and the maximum transverse fluid flow velocity is close to 0.15 m/s. Additionally, the longitudinal fluid flow velocity is opposite the upper and lower portions of the longitudinal flow velocity, and there is a swirling phenomenon in the propane flame jet. From the vorticity level, the closer to the centre of the jet in the vortex plane, the faster the air flow speed, and simultaneously, in the upper and lower parts of the vortex, the air flow travels in the opposite direction and is of equal size. The particle image velocimetry platform that was independently designed in this study can efficiently characterise the dynamic flow field and the flow characteristics of complex combustion chambers, simultaneously ensuring high efficiency and reducing research costs. It provides a measurement method and experimental basis for the development of fire extinguishing equipment and numerical simulation, while also helping us to carry out a series of subsequent studies on fire extinguishing mechanisms.
Assessment of Humic and Fulvic Acid Sorbing Potential for Heavy Metals in Water
Authors: Papadaki Eirini S. , Chatzimitakos Theodoros , Athanasiadis Vassilis , Kalompatsios Dimitrios , Bozinou Eleni , Mitlianga Paraskevi , Lalas Stavros I.
Published: December 2023

Pollution of water sources with heavy metals is a pressing environmental issue. To this end, various procedures are being used to remediate water, including sorption. The aim of this study was to investigate the effectiveness of humic acids (HAs) and fulvic acids (FAs) for the removal of metals from water. Specifically, HA and FA were examined for their potential to be used as sorbent materials for 26 heavy metals, alkali metals, and alkaline earth metals. HA and FA were isolated from lignite samples from two mines (Mavropigi mine and South Field mine, Kozani, West Macedonia, Greece). Experiments were carried out using natural mineral water without pH adjustment, so as to gain a better overview of the sorption efficiency in real-life samples. The results showed that FAs were able to sorb most of the examined metals compared to HAs. Several metals such as Ba (34.22–37.77%), Ca (99.12–99.58%), and Sr (97.89–98.12%) were efficiently sorbed when 900 ppm of FAs from both sources were used but were not sorbed by HAs from any source (≤0.1%). Due to the functional groups on the surface of FA, it is plausible to conclude that it can remove more metals than HA. Meanwhile, lignite from the South Field mine was found to be more efficient for the sorption efficiency in lower concentrations (300–600 ppm), whereas lignite from the Mavropigi mine was more effective in higher concentrations (900 ppm). For instance, higher removal rates were observed in Mo (62.84%), Pb (56.81%), and U (49.22%) when 300 ppm of HAs of South Field mine were used, whilst the employment of 900 ppm of HAs from Mavropigi mine led to high removal rates of As (49.90%), Se (64.47%), and Tl (85.96%). The above results were also reflected in a principal component analysis, which showed the dispersion of the metal parameters near to or far from the HA and FA parameters depending on their sorption capacity. Overall, both HA and FA could be effectively utilized as sorbent materials for metal removal from water samples. The results of the research indicate a potential application to the remediation of water from metals under dynamic conditions in order to protect public health.
Finite Difference Scheme and Finite Volume Scheme for Fractional Laplacian Operator and Some Applications
Authors: Wang Junjie , Yuan Shoucheng , Liu Xiao
Published: December 2023

The fractional Laplacian operator is a very important fractional operator that is often used to describe several anomalous diffusion phenomena. In this paper, we develop some numerical schemes, including a finite difference scheme and finite volume scheme for the fractional Laplacian operator, and apply the resulting numerical schemes to solve some fractional diffusion equations. First, the fractional Laplacian operator can be characterized as the weak singular integral by an integral operator with zero boundary condition. Second, because the solutions of fractional diffusion equations are usually singular near the boundary, we use a fractional interpolation function in the region near the boundary and use a classical interpolation function in other intervals. Then, we apply a finite difference scheme to the discrete fractional Laplacian operator and fractional diffusion equation with the above fractional interpolation function and classical interpolation function. Moreover, it is found that the differential matrix of the above scheme is a symmetric matrix and strictly row-wise diagonally dominant in special fractional interpolation functions. Third, we show a finite volume scheme for a discrete fractional diffusion equation by fractional interpolation function and classical interpolation function and analyze the properties of the differential matrix. Finally, the numerical experiments are given, and we verify the correctness of the theoretical results and the efficiency of the schemes.
Study on the Influence of Sample Size on the Mechanical and Integrity Characteristics of Coal Measure Sandstone under High Strain Rate
Authors: Yi Enbing , Li Zhenhua
Published: December 2023

In order to explore the size effect of the mechanical and damage characteristics of coal measure sand stones under dynamic load, uniaxial impact compression tests were carried out on coal-bearing sand stones with a diameter of 50 mm and a length–diameter ratio of L/R = 0.5, 0.8, 1, 1.2, 1.5, 1.8, and 2 by using the Hopkinson pressure bar test system. The size effect law of the mechanical properties and energy dissipation of coal-bearing sandstone under a high strain rate were investigated. Then, the mercury injection test was carried out on the fragments at different positions, and the electron microscope scanning test was carried out on the fragments near the end of the transmission rod. Based on the area damage definition method and normalization treatment, the integrity model of coal measure sandstone, considering the influence of the length–diameter ratio, was established. The results showed that the peak strength and dynamic elastic modulus of coal measure sandstone increased first and then decreased with the increase in length–diameter ratio under impact compression load, and they reached the maximum when the length–diameter ratio was 1.2. The dynamic peak strain increased gradually with the increase in length–diameter ratio. The energy of coal-bearing sandstone showed strong size effect, that is, the total absorbed energy, elastic energy, and dissipated energy increased with the increase in length–diameter ratio, and the size effect of total absorbed energy was the most obvious. Under the same impact pressure, the porosity of coal-bearing sand stones with seven kinds of length–diameter ratios near the incident end was roughly the same. But when the length–diameter ratio was greater than 0.5, the porosity decreased gradually with the increase in the distance from the incident end. And the larger the length–diameter ratio, the more obvious the decreasing trend. When the length–diameter ratio was smaller, the size of the holes and cracks and the cluster density were larger. The integrity model of coal measure sandstone, considering the influence of the length–diameter ratio, showed that the larger the length–diameter ratio, the better the relative integrity of coal-bearing sandstone.
Evaluation of Cell-Specific Alterations in Alzheimer’s Disease and Relevance of In Vitro Models
Authors: Guido Giorgio , Mangano Katia , Tancheva Lyubka , Kalfin Reni , Leone Gian Marco , Saraceno Andrea , Fagone Paolo , Nicoletti Ferdinando , Petralia Maria Cristina
Published: December 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder classically characterized by two neuropathological hallmarks: β-amyloid plaques and tau tangles in the brain. However, the cellular and molecular mechanisms involved in AD are still elusive, which dampens the possibility of finding new and more effective therapeutic interventions. Current in vitro models are limited in modelling the complexity of AD pathogenesis. In this study, we aimed to characterize the AD expression signature upon a meta-analysis of multiple human datasets, including different cell populations from various brain regions, and compare cell-specific alterations in AD patients and in vitro models to highlight the appropriateness and the limitations of the currently available models in recapitulating AD pathology. The meta-analysis showed consistent enrichment of the Rho GTPases signaling pathway among different cell populations and in the models. The accuracy of in vitro models was higher for neurons and lowest for astrocytes. Our study underscores the particularly low fidelity in modelling down-regulated genes across all cell populations. The top enriched pathways arising from meta-analysis of human data differ from the enriched pathways arising from the overlap. We hope that our data will prove useful in indicating a starting point in the development of future, more complex, 3D in vitro models.
Quality of Bokashi-Type Biofertilizer Formulations and Its Application in the Production of Vegetables in an Ecological System
Authors: Kruker Gregory , Guidi Eduardo Schabatoski , Santos Juliano Muniz da Silva dos , Mafra Álvaro Luiz , Almeida Jaime Antonio de
Published: December 2023

Current agriculture faces the challenge of producing food with the least interference from the environment. In this sense, the implementation of ecological agricultural practices is essential to obtaining healthy and more sustainable production systems. The objective of this study was to investigate the impact of different inoculation technologies on formulations of bokashi-type biofertilizer and its application as soil and substrate organic amendment. We examined the effects of treatments on the chemical and biological quality of the evaluated formulations, as well as their influence on the agronomic and nutritional characteristics of red-beet and cabbage crops in the field. The metagenomic analysis of the taxonomic profile of the microbiological populations revealed relative abundance of plant growth-promoting rhizobacterial genera, including Azospirillum sp., Rhizobium sp., Bradyrhizobium sp., Burkholderia sp., Paraburkholderia sp., and Paenibacillus sp. in the evaluated formulations. Additionally, no phytopathogenic contaminants were detected among the investigated treatments. The highest yields of field-grown beet crops were obtained from seedlings produced using the following treatments: bokashi biofertilizer + biodynamic preparations P502-P507, bokashi + Chamomilla 12 CH, and bokashi + Carbo vegetabilis 12 CH. The increase in productivity of cabbage plants was higher in the treatment bokashi + Calcarea carbonica 12 CH.
Genome-Wide Analysis of the Related to ABI3/VP1 Family Genes in Chrysanthemum seticuspe Reveals Their Response Patterns to Exogenous Ethylene Treatment
Authors: Cheng Hua , Yang Yiman , Li Jiayu , Chen Sumei , Chen Fadi , Jiang Jiafu
Published: December 2023

The transcription factor family RELATED to ABSCISIC ACID INSENSITIVE3 (ABI3)/VIVIPAROUS1(VP1) (RAV) is a plant-specific group of transcription factors that only contain a conserved B3 DNA binding domain or both their own B3 and APETALA2 (AP2) domains belonging to the B3 superfamily, which is vital for plant growth, development, and stress response. Although genome-wide characterization and analysis of the RAV family genes have been conducted in some species, they have not been systematically reported in chrysanthemums. Here, we found six RAV family genes in the diploid Chrysanthemum seticuspe genome. Based on domain similarity and homology comparison analyses, RAV genes in Chrysanthemum were categorized into two clades: Class-I and Class-II. Conserved motif analysis revealed that all CsRAV proteins contained the B3 repression domain. An analysis of cis-acting elements suggested that CsRAV family genes may play parts in light, hormonal, abiotic stress, growth, and developmental processes. Furthermore, quantitative RT-PCR analysis validated that all six CsRAV genes responded to ethylene treatment, whereas the genes in the Class-I clade responded most significantly to ethylene. In summary, the above results provided a conceptual basis for further investigation into the functions of CsRAV genes in C. seticuspe.
Risk Factors for Alcohol Consumption after Starting Assisted Reproductive Technology Treatment among Japanese Women: Japan-Female Employment and Mental Health in Assisted Reproductive Technology (J-FEMA) Study
Authors: Sato Mamiko , Endo Motoki , Tomooka Kiyohide , Kuroda Keiji , Ueda Yuito , Sato Setsuko , Ikemoto Yuko , Imai Yuya , Mitsui Kiyomi , Tanaka Atsushi , Sugiyama Rikikazu , Nakagawa Koji , Sato Yuichi , Kuribayashi Yasushi , Kitade Mari , Itakura Atsuo , Takeda Satoru , Tanigawa Takeshi
Published: December 2023

Aims: To determine the association between drinking habits and social factors among women undergoing assisted reproductive technology (ART) treatment in Japan. Methods: The study participants who provided answers for the questionnaire concerning alcohol consumption were 1017 female patients undergoing ART treatment were enrolled in the Japan-Female Employment and Mental Health in assisted reproductive technology (J-FEMA) study between August and December 2018. Patient characteristics, including demographic, clinical, and socioeconomic status, were assessed using a self-administered questionnaire which was distributed only once during the period, regardless of their first or follow-up examination. We defined current drinkers who drank ≥46 g of ethanol per week as the habitual drinking group. The risk factors for habitual drinking were analyzed using multivariable-adjusted logistic regression. Results: The proportion of habitual drinkers was 15.5% in this study population. The multivariable-adjusted odds ratios (95% confidence interval) for habitual drinking were 2.27 (0.99–5.21) for women aged ≥35 years versus those <35 years, 4.26 (1.98–9.16) for women having partners who currently drink compared to those with partners without current drinking, 1.84 (1.08–3.12) for women without a history of childbirth versus those with, and 1.77 (1.00–3.14) for working women compared with those not working. Conclusions: In our study, habitual drinking among women undergoing ART treatment was significantly associated with older age, no history of childbirth, partner’s current drinking status, and working.
State-of-the-Art Review on Amorphous Carbon Nanotubes: Synthesis, Structure, and Application
Authors: Ren Xiaona , Hussain Muhammad Irfan , Chang Yue , Ge Changchun
Published: December 2023

Carbon nanotubes (CNTs) have rapidly received increasing attention and great interest as potential materials for energy storage and catalyst fields, which is due to their unique physicochemical and electrical properties. With continuous improvements in fabrication routes, CNTs have been modified with various types of materials, opening up new perspectives for research and state-of-the-art technologies. Amorphous CNTs (aCNTs) are carbon nanostructures that are distinctively different from their well-ordered counterparts, such as single-walled and multi-walled carbon nanotubes (SWCNTs and MWCNTs, respectively), while the atoms in aCNTs are grouped in a disordered, crystalline/non-crystalline manner. Owing to their unique structure and properties, aCNTs are attractive for energy storage, catalysis, and aerospace applications. In this review, we provide an overview of the synthetic routes of aCNTs, which include chemical vapor deposition, catalytic pyrolysis, and arc discharge. Detailed morphologies of aCNTs and the systematic elucidation of tunable properties are also summarized. Finally, we discuss the future perspectives as well as associated challenges of aCNTs. With this review, we aim to encourage further research for the widespread use of aCNTs in industry.
NREL-5MW Wind Turbine Noise Prediction by FWH-LES
Authors: Bernardi Claudio , Porcacchia Federico , Testa Claudio , De Palma Pietro , Leonardi Stefano , Cherubini Stefania
Published: December 2023

This paper deals with large onshore wind turbine aeroacoustics. Noise from the NREL 5 MW device is predicted by the permeable-surface Ffowcs Williams–Hawkings equation (FWH-P), starting from the postprocessing of LES data on different acoustic surfaces S. Their size and placement is aimed at embedding most of the aerodynamic sources of sound surrounding rotor and nacelle. Due to the presence of eddies that inevitably cross S, this paper compares results from open and closed acoustic surfaces, and the outflow disk averaging technique. The issues related to the interpolation process of LES data on S is discussed as well. In order to assess the LES/FWH-P aeroacoustic platform, LES and FWH-P pressures are compared in the very-near field. It is shown that, within the limits of the discretization settings imposed by the interpolation procedure and for the Reynolds number working condition investigated herein, the lack of quadrupole sources outside the permeable surface(s) deeply affect the quality of FWH-P acoustic pressures with respect to direct LES signals.
The Role of Trust in Dependence Networks: A Case Study
Authors: Falcone Rino , Sapienza Alessandro
Published: December 2023

In a world where the interconnection and interaction between human and artificial agents are continuously increasing, the dynamics of social bonds and dependence networks play a fundamental role. The core of our investigation revolves around the intricate interplay between dependence and trust within a hybrid society, populated by human and artificial agents. By means of a structural theory, this study offers valuable insights into the utilization of dependence networks and their impact on collaborative dynamics and resource management. Most notably, agents that leverage dependence, even at the cost of interacting with low-trustworthiness partners, achieve superior performance in resource-constrained environments. On the other hand, in contexts where the use of dependence is limited, the role of trust is emphasized. These findings underscore the significance of dependence networks and their practical implications in real-world contexts, offering useful practical implications in areas such as robotics, resource management, and collaboration among human and artificial agents.
The Application of Bamboo in the Railway Industry: A Sustainable Solution for Track Construction
Authors: He Xinrui , Jia Wenli , Dong Yuxiang , Siahkouhi Mohammad
Published: December 2023

The railway industry has shown a strong interest in utilizing sustainable materials, including recycled materials and composites, in construction. Bamboo, as a highly renewable natural resource, has been proposed as a construction material for the railway industry. This material offers several advantages, such as high strength and durability, sustainability, low embodied energy, and ease of handling. It has been used in various construction materials like plywood, scrimber, laminates, and fibers. This paper aims to review the application of bamboo as a material in the railway industry and provide suggestions for its future use as railway sleepers. The mechanical properties of bamboo and its desirable features for sleeper construction, such as versatility, durability, low embodied energy and carbon footprint, lightweight, and ease of handling, are discussed. Bamboo-based products like plywood and scrimber can offer higher mechanical properties compared to traditional timber sleepers. Moreover, due to its rapid growth rate, bamboo is considered an environmentally friendly material. However, there are certain factors that limit the widespread deployment of bamboo in the railway industry. For instance, the lightweight nature of bamboo can reduce the lateral resistance of sleepers. Additionally, long-term performance studies and its performance in regions with varying weather conditions need to be further investigated. This review paper aims to promote the increased utilization of bamboo in the railway industry, contributing to the development of sustainable railway tracks. By considering the mechanical properties and advantageous characteristics of bamboo, it is possible to explore its potential as a viable and eco-friendly material for railway sleepers.
Asymmetric Dual-Grating Dielectric Laser Accelerator Optimization
Authors: Crisp Sophie , Ody Alexander , Musumeci Pietro
Published: December 2023

Although hundreds of keV in energy gain have already been demonstrated in dielectric laser accelerators (DLAs), the challenge of creating structures that can confine electrons for multiple millimeters remains. We focus here on dual gratings with single-sided drive, which have experimentally demonstrated energy modulation numerous times. Using a Finite-Difference Time-Domain simulation to find the fields within various DLA structures and correlating these results with particle tracking simulation, we look at the impact of teeth height and width, as well as gap and offset, on the performance of these structures. We find a tradeoff between electron throughput and acceleration; however, we also find that for any given grating geometry, there is a gap and offset that will allow some charge acceleration. For our 780 nm laser wavelength, this results in a 1200 nm optimal gap size for most gratings.
COVID-19 Vaccination-Related Delayed Adverse Events among Patients with Systemic Lupus Erythematosus
Authors: Dey Mrinalini , Doskaliuk Bohdana , Lindblom Julius , Nikiphorou Elena , Wincup Chris , Fathima Madiha , Saha Sreoshy , Shaharir Syahrul Sazliyana , Katchamart Wanruchada , Goo Phonpen Akarawatcharangura , Traboco Lisa , Chen Yi-Ming , Kadam Esha , Lilleker James B. , Nune Arvind , Pauling John D. , Agarwal Vishwesh , Dey Dzifa , Toro Gutierrez Carlos Enrique , Caballero Carlo Vinicio , Chinoy Hector ,   COVAD Study Group, Aggarwal Rohit , Agarwal Vikas , Gupta Latika , Parodis Ioannis
Published: December 2023

Background: The safety profile of COVID-19 vaccination is well documented, but hesitancy among people with immune-mediated inflammatory diseases, often immunocompromised, remains high, partially due to a scarcity of data on safety over a longer term. We herein aimed to assess delayed adverse events (DAEs) occurring >7 days after COVID-19 vaccination in systemic lupus erythematosus (SLE) versus other rheumatic autoimmune diseases (rAIDs), non-rheumatic AIDs (nrAIDs), and healthy controls (HCs). Methods: Self-reported data were captured within the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 online survey, which comprised >150 centres and responses from 106 countries, between February and June 2022. Logistic regression analysis adjusting for important confounders (age, sex, ethnicity) was used to compare groups. Results: Of 7203 eligible individuals, 882 (12.2%) patients had SLE, 3161 (43.9%) patients had rAIDs, 426 (5.9%) patients had nrAIDs, and 2734 (38.0%) were HCs. SLE patients had a median age of 39 years (IQR: 31–50); 93.7% were women. SLE patients reported, more frequently, major DAEs (OR: 1.6; 95% CI: 1.2–2.0; p = 0.001) and hospitalisation (OR: 2.2; 95% CI: 1.4–3.4; p < 0.001) compared to HCs, severe rashes (OR: 2.4; 95% CI: 1.3–4.2; p = 0.004) compared to people with rAIDS, and hospitalisation (OR: 2.3; 95% CI: 1.1–4.9; p = 0.029) as well as several minor DAEs compared to people with nrAIDs. Differences were observed between vaccines in terms of frequency of major DAEs and hospitalisations, with the latter seen more frequently in patients receiving the Moderna vaccine. People with SLE with no autoimmune multimorbidity less frequently reported overall minor DAEs compared to SLE patients with comorbid nrAIDs (OR: 0.5; 95% CI: 0.3–1.0; p = 0.036). Conclusion: Hospitalisations post-vaccination were more frequent in SLE patients than in HCs. Monitoring of SLE patients following COVID-19 vaccination can help in identifying DAEs early, informing patients about expected DAEs, and supporting patients, especially those with autoimmune multimorbidity.
Feature-Tracking-Derived Strain Analysis for Identification of Subendocardium-Involved Late Gadolinium Enhancement in Load-Induced Left Ventricular Hypertrophy: A Multicenter Study of Cardiac Magnetic Resonance Data
Authors: Zhong Ying , Long Qian , Zeng Mu , Wu Lianming , Guo Liang , Wang Guan
Published: December 2023

Background: Subendocardium-involved late gadolinium enhancement (SILGE) is a significant predictor of poor prognosis in patients with load-induced left ventricular hypertrophy (LVH). Objectives: This multicenter study aimed to investigate whether the diagnostic performance of cardiac magnetic resonance feature-tracking (CMR-FT)-derived strain analysis for detecting subtle subendocardial injury would be influenced by its load dependence in patients with load-induced LVH. Methods: A total of 149 patients with load-induced LVH were recruited from three centers and underwent enhanced CMR imaging. The patients were divided into two groups based on the presence or absence of SILGE on CMR (SILGE+ group: n = 56; SILGE− group: n = 93). Clinical and CMR parameters were evaluated in both groups. Results: The LV systolic pressure (LVSP) and LV end-diastolic pressure (LVEDP) in the SILGE+ group were higher than those in the SILGE− group (each with p < 0.05), and LVSP and LVEDP were correlated with the LV global longitudinal strain (GLS) (each with p < 0.05) in research center 1. The LV strain parameters were significantly lower in the SILGE+ group than those in the SILGE− group (each with p < 0.05). Logistic regression analysis identified GLS (OR 1.325; 95% CI 1.180 to 1.487, p < 0.001) as a predictive factor of SILGE in the patients with load-induced LVH. The receiver operating characteristic (ROC) curve analysis results indicated that the areas under the curve (AUC) of global radial strain (GRS), global circumferential strain (GCS), and GLS were 0.68, 0.69, and 0.76, respectively. De Long’s test results implied that GLS had the best diagnostic performance for SILGE (p = 0.04). Conclusion: Despite the load dependency of CMR-FT-derived strain analysis, the GLS exhibits reasonable accuracy in the identification of SILGE and can potentially serve as a feasible alternative for detecting subendocardial involvement in patients with load-induced LVH who are contraindicated for LGE.
Association between Leukocyte Cell-Derived Chemotaxin 2 and Metabolic and Renal Diseases in a Geriatric Population: A Pilot Study
Authors: Kuzan Aleksandra , Maksymowicz Krzysztof , Królewicz Emilia , Lindner-Pawłowicz Karolina , Zatyka Piotr , Wojnicz Piotr , Nowaczyński Maciej , Słomczyński Adam , Sobieszczańska Małgorzata
Published: December 2023

LECT2 is not a routine diagnostic marker for any disease, but it has been associated with many pathologies, including systemic amyloidosis, rheumatoid arthritis, diabetes, atherosclerosis, and metabolic syndrome. With human aortic sections (n = 22) and sera from geriatric subjects (n = 79), we analyzed the relationships that could be observed between this protein and other parameters related to metabolic diseases. As a result, we observed a relatively high (r~0.8, p < 0.05) positive correlation between SRA and LECT2 and a negative correlation between EGFR and LECT2 (r~−0.4, p < 0.05). We observed LECT2 expression in macrophages, myocytes, and other aortic cells, with a tendency to be overexpressed in developed atherosclerotic plaques. We conclude that LECT2 exerts its chemotactic effects not only as a protein synthesized in the liver and secreted and circulating in the blood but also as a locally expressed protein within atherosclerotic plaque development. The LECT2-EGFR correlation suggests an association of this protein with loss of normal renal function. This fact can be associated with LECT2 amyloidosis, although it should be verified whether in the geriatric population there is indeed a widespread accumulation of LECT2 with the progression of aging or whether it is rather a marker of general deterioration of renal function.
How to Diagnose and Risk Stratify Brugada Syndrome. Comment on Matusik et al. Twelve-Lead ECG, Holter Monitoring Parameters, and Genetic Testing in Brugada Syndrome: Insights from Analysis of Multigenerational Family with a History of Sudden Cardiac Arrest during Physical Activity. J. Clin. Med. 2023, 12, 6581
Authors: Kataoka Naoya , Imamura Teruhiko
Published: December 2023

Brugada syndrome stands as an arrhythmogenic disorder bearing the grim specter of heightened susceptibility to syncopal episodes and sudden cardiac demise [...]
First Principle Study of Structural, Electronic, Optical Properties of Co-Doped ZnO
Authors: Soussi Ahmed , Haounati Redouane , Ait hssi Abderrahim , Taoufiq Mohamed , Asbayou Abdellah , Elfanaoui Abdeslam , Markazi Rachid , Bouabid Khalid , Ihlal Ahmed
Published: December 2023

In this theoretical study, the electronic, structural, and optical properties of copper-doped zinc oxide (CZO) were investigated using the full-potential linearized enhanced plane wave method (FP-LAPW) based on the density functional theory (DFT). The Tran–Blaha modified Becke–Johnson exchange potential approximation (TB-mBJ) was employed to enhance the accuracy of the electronic structure description. The introduction of copper atoms as donors in the ZnO resulted in a reduction in the material’s band gap from 2.82 eV to 2.72 eV, indicating enhanced conductivity. This reduction was attributed to the Co-3d intra-band transitions, primarily in the spin-down configuration, leading to increased optical absorption in the visible range. The Fermi level of the pure ZnO shifted towards the conduction band, indicating metal-like characteristics in the CZO. Additionally, the CZO nanowires displayed a significant blue shift in their optical properties, suggesting a change in the energy band structure. These findings not only contribute to a deeper understanding of the CZO’s fundamental properties but also open avenues for its potential applications in optoelectronic and photonic devices, where tailored electronic and optical characteristics are crucial. This study underscores the significance of computational techniques in predicting and understanding the behavior of doped semiconductors, offering valuable insights for the design and development of novel materials for advanced electronic applications.
Overexpression of the Transcription Factor Azf1 Reveals Novel Regulatory Functions and Impacts β-Glucosidase Production in Trichoderma reesei
Authors: Maués David Batista , Maraschin Jhonatan Christian , Duarte Diego Ângelo , Antoniêto Amanda Cristina Campos , Silva Roberto N.
Published: December 2023

The fungus Trichoderma reesei is an essential producer of enzymes that degrade lignocellulosic biomass to produce value-added bioproducts. The cellulolytic system of T. reesei is controlled by several transcription factors (TFs) that efficiently regulate the production of these enzymes. Recently, a new TF named Azf1 was identified as a positive regulator of cellulase expression. Here, we investigated novel regulatory functions of Azf1 by its overexpression. In the mutant strain OEazf1, overexpression of azf1 was achieved under both repression and induction conditions. Although azf1 was more abundant in transcript and protein, overexpression of this TF did not activate transcription of the cellulase gene in the presence of the repressor glucose, suggesting that Azf1 may be subject to posttranslational regulation. In cellulose, the expression of swo, encoding the accessory protein swollenin, and the β-glucosidases cel1a, cel1b, cel3b, and cel3g increases in the early stages of cultivation. The increased production of these β-glucosidases increases the hydrolysis rate of cellobiose and sophorose, which activates carbon catabolite repression (CCR) and causes repression of cellulase genes and the regulator Xyr1 in the later stages of cultivation. Moreover, overexpression of azf1 led to increased cellulase activity in T. reesei during long-term cultivation in cellulose and sugarcane bagasse. Our results provide new insights into the mechanisms regulating Azf1 and novel genes that are important targets of this TF. This work contributes to a better understanding of the complex mechanisms regulating cellulase expression in T. reesei. It will contribute to the development of strains with higher production of these essential enzymes.
Optimal and Non-Optimal MACD Parameter Values and Their Ranges for Stock-Index Futures: A Comparative Study of Nikkei, Dow Jones, and Nasdaq
Authors: Kang Byung-Kook
Published: December 2023

This study investigates the optimal and non-optimal parameter values of the MACD (Moving Average Convergence Divergence) technical analysis indicator for three major stock market index futures: the Nikkei 225, the Dow Jones, and the Nasdaq. Using a recently developed methodology, it reveals the existence of specific ranges of optimal and non-optimal values for each of the three parameters of the MACD indicator in these indices. Sample models employing the optimal parameter values in the three index futures generated significantly higher returns, outperforming both a non-technical buy-and-hold strategy and a random strategy that did not incorporate any market information. This discovery suggests that the three market indices may not be weak-form efficient. Therefore, this study contributes to the research on market efficiency by verifying inefficiency using a new approach. The highlight of this study is identifying that the ranges of optimal parameter values for the three indices are different from each other, but the optimal parameter value combinations for each of the three indices share a unique characteristic form. This issue and its finding have not been explored in the existing literature. Several interesting findings and valuable insights for market participants and researchers arise from this study. The new methodology is unique in finding optimal and non-optimal parameter values through the analysis of parameter sets used in well-performing and poorly performing sample models. Its validity and reliability have been confirmed by this study, making a useful contribution to the field of technical analysis research, particularly in parameter optimization insight.
Socioecological Dynamics and Forest-Dependent Communities’ Wellbeing: The Case of Yasuní National Park, Ecuador
Authors: Dominguez-Gaibor Isabel , Talpă Nicolae , Bularca Maria Cristina , Hălălișan Aureliu Florin , Coman Claudiu , Popa Bogdan
Published: December 2023

Protected areas are considered the backbone of biodiversity conservation, but their management often fails because local people are not involved, and their needs are ignored. A socioecological approach has been demonstrated to be effective in improving the relationship between conservation efforts and human wellbeing through a better understanding of the interdependence between nature and people. This relationship can be observed through the case of the Kichwa indigenous communities within Yasuní National Park, Ecuador, as they have retained a very close relationship with forest ecosystems. Using key respondent interviews, along with semi-structured interviews and focus groups, this research describes the complex relationship between changing forest ecosystems and human wellbeing. The results highlight food, health, and cultural identity as the most important benefits that communities obtain from forests. The research also sheds light on how people in the investigated area perceive the dynamics of socioecological systems, indicating petroleum, infrastructure development, and small-scale agriculture as the most important direct drivers and land governance and the presence of colonists as the most important indirect drivers of changes to forest ecosystems. This paper demonstrates the importance of monitoring socioecological systems and adapting management to balance complex economic, social, and ecological challenges.
Incorporating Immunotherapy with Radiotherapy for Lymphomas
Authors: Strati Paolo , Spiotto Michael T.
Published: December 2023

Radiotherapy and/or chemotherapy have been used for nearly 100 years to treat lymphoma. Recently, immunotherapy has been incorporated into the treatment of lymphomas. Here, we will review both the role of immunotherapy in lymphoma as well as the feasibility of incorporating immunotherapies with conventional lymphoma treatments, especially radiotherapy. Immunotherapy agents include checkpoint inhibitors that target the PD-1/PD-L1 axis, CTLA-4, or CD47. In addition, other immunotherapy agents such as bi-specific antibodies and CD19 CAR-T cell therapy are being implemented in various non-Hodgkin’s lymphomas. Extrapolating from observations in other disease sites and incorporating immunotherapy with conventional treatments of lymphoma, including radiotherapy, may have opposing effects. Radiotherapy may stimulate anti-tumor immune responses that synergize with immunotherapies. In contrast, radiotherapy, as well as chemotherapy, may also induce local and systemic immune dysfunction which reduces the efficacy of immunotherapies. With newer radiation treatment techniques and limited radiation fields, it is likely that the efficacy of immunotherapy can be maintained when included with conventional treatments. Therefore, there remains an unmet need to better understand the role of immunotherapy alone and in combination with current treatments in lymphoma patients.
The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses
Authors: Seretis Konstantinos , Bounas Nikolaos , Sioka Chrissa
Published: December 2023

Background and Objectives: Previous studies revealed the anti-angiogenic, antiproliferative, and anti-inflammatory effects of Vitamin D (VitD) on cancer cells. Although this body of evidence supported the correlation of high VitD levels with reduced incidence rates for various malignancies, contradictory results were reported regarding non-melanoma skin cancer (NMSC). The aim of this overview was to summarize the available evidence from the existing pool of systematic reviews and meta-analyses, focusing on VitD serum status, dietary intake, and VitD receptor (VDR) polymorphisms in correlation to NMSC incidence. Materials and Methods: A literature search in electronic databases was conducted from inception to January 2023. The inclusion criteria were systematic reviews and meta-analyses published in peer-reviewed journals, evaluating VitD serum levels, dietary and/or supplementary intake, or VDR gene polymorphisms, and reporting data on NMSC. Results: A total of 10 studies were included in the data analysis models. A positive association between VitD serum levels and NMSC is highlighted. However, dietary/supplementation of VitD does not exhibit a likewise strong linkage to NMSC. Despite the contradictory findings, VDR polymorphisms may play a crucial role in the intricate NMSC pathogenesis. Conclusions: This umbrella review shows that high VitD levels are associated with increased NMSC incidence, potentially due to its direct correlation with increased sun exposure. Further research on VDR polymorphisms is suggested to explore their true effect size on NMSC risk.
Distinctive Geometrical Traits of Proximal Femur Fractures—Original Article and Review of Literature
Authors: Vlachos Christos , Ampadiotaki Margarita Michaela , Papagrigorakis Eftychios , Galanis Athanasios , Zachariou Dimitrios , Vavourakis Michail , Rodis George , Vasiliadis Elias , Kontogeorgakos Vasileios A. , Pneumaticos Spiros , Vlamis John
Published: December 2023

Background and Objectives: The incidence of proximal femoral fractures is escalating rapidly, generating a significant challenge for healthcare systems globally and, carrying serious social and economic implications. The primarily object of this study was to discover potential distinguishing factors between fractures occurring in the femoral neck and trochanteric region. Materials and Methods: We performed a prospective cohort study of the radiographic images of 70 people over 65 years of age who were admitted to the orthopedic department with hip fracture and who fulfilled our eligibility criteria. Neck Length (NL), Offset Lenth (OL), Hip Axis Length (HAL), Neck Shaft Angle (NSA), Wiberg Angle (WA), Acetabular Angle (AA), Femoral Neck Diameter (FND), Femoral Head Diameter (FHD), Femoral Shaft Diameter (FSD), Femoral Canal Diameter (FCD) and Tonnis classification were recorded. For the comparison of the categorical variables, Pearson’s χ2 criterion was used, while Student’s t-test was applied for the comparison of means of quantitative variables across fracture types. Results: There were no statistically significant variances observed while comparing the selected geometric parameters of the proximal femur with the type of fracture. This finding was reaffirmed in relation to age, gender, and Tonnis classification. However, a moderate correlation was noted, revealing comparatively reduced values of HAL, FHD, and FND in women as opposed to men. Conclusions: The inability of our research to establish the differentiative geometric factors between femoral neck and trochanteric fractures underscores the need for further investigations, which would take into consideration the intrinsic characteristics of the proximal femur.
Inverse Magnetocaloric Effect in Heusler Ni44.4Mn36.2Sn14.9Cu4.5 Alloy at Low Temperatures
Authors: Kamantsev Alexander P. , Koshkid’ko Yuriy S. , Gaifullin Ruslan Yu. , Musabirov Irek I. , Koshelev Anatoliy V. , Mashirov Alexey V. , Sokolovskiy Vladimir V. , Buchelnikov Vasiliy D. , Ćwik Jacek , Shavrov Vladimir G.
Published: December 2023

Direct measurements of the magnetocaloric effect were performed in a Heusler Ni44.4Mn36.2Sn14.9Cu4.5 alloy at cryogenic temperatures in magnetic fields up to 10 T. The maximum value of the inverse magnetocaloric effect in a 10 T field was ∆Tad = –2.7 K in the vicinity of the first-order magnetostructural phase transition at T0 = 117 K. Ab initio and Monte Carlo calculations were performed to discuss the effect of Cu doping into a Ni-Mn-Sn compound on the ground-state structural and magnetic properties. It is shown that with increasing Cu content the martensitic transition temperature decreases and the Curie temperature of austenite slightly increases. In general, the calculated transition temperatures and magnetization values correlated well with the experimental ones.