bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of FBG Sensing Technology for Real-Time Monitoring in High-Stress Tunnel Environments
Authors: Ren Chao , Sun Xiaoming , He Manchao , Tao Zhigang
Published: September 2024

In the process of tunnel construction, problems such as high-stress rockburst, large deformation of soft rock, water inrush and mud gushing, secondary cracking of linings, blasting interference, man-made damage, and mechanical damage are often encountered. These pose a great challenge to the installation of monitoring equipment and line protection. In order to solve these problems, the 2# inclined shaft of Muzhailing Tunnel in the Gansu Province of China, which exists under high stress, water bearing, and bias conditions, was taken as the research object in this paper. By assembling a string, drilling grouting and sealing, and introducing multiple modes of protection, new fiber grating sensor group installation and line protection methods were proposed. The automatic continuous monitoring of the deep deformation of surrounding rock and the automatic continuous monitoring of steel arch stress were realized. The field monitoring results showed that: (1) the fiber grating displacement sensor group could be used to verify the authenticity of the surface displacement results monitored by the total station; (2) the NPR anchor cable coupling support effectively limited the large deformation of soft rock and the expansion of surrounding rock in a loose circle, and the range of the loose circle was stable at about 1 m; and (3) the main influence range of blasting was at a depth of 0~5 m in surrounding rock, and about 25 m away from the working face. In addition, to secure weak links in the steel arch due to the hardening phenomenon, a locking tube was set at the arch foot. In the support design, the fatigue life of the steel was found to be useful as the selection index for the steel arch frame to ensure the stability of the surrounding rock and the long-term safety of the tunnel. The present research adopted a robust method and integrates a variety of sensor technologies to provide a multifaceted view of the stresses and deformations encountered during the tunneling process, and the effective application of the above results could have certain research and reference value for the design and monitoring of high stress, water-bearing, and surrounding rock supports in tunnels.
Design, Experiments, and Path Planning for a Lightweight 3D Minimally Actuated Serial Robot with a Mobile Actuator
Authors: Bitton Or , Cohen Avi , Zarrouk David
Published: September 2024

This paper presents a novel three-dimensional (3D) minimally actuated serial robot (MASR) and its unique kinematic analysis. Unlike traditional robots, the 3D MASR features a passive arm devoid of wires or motors, comprising passive rotational and prismatic joints. A single mobile actuator (MA) traverses the arm, engages designated joints for operation, and locks them in place with a worm gear setup. A gripper is attached to the MA, enabling object transportation along the arm, reducing joint actuation, and optimizing task completion time. Our key contributions include the mechanical design, and in particular the robot’s passive joints with their automated actuation mechanism, and a novel optimization algorithm leveraging neural networks (NNs) to minimize task completion time through advanced kinematic analysis. Experiments with a physical prototype of the 3D MASR demonstrate its major advantages: it is remarkably lightweight (2.3 kg for a 1 m long arm and a 1 kg payload) compared to similar robots; it is highly modular (five joints R and P actuated by a single MA); and part replacement is effortless due to the absence of wiring along the arm. These features are visually depicted in the accompanying video.
Neck Strength Variations in Dental Students with and without Neck Pain: A Longitudinal Study
Authors: Almeida Manuel Barbosa , Moreira Marion , Moleirinho-Alves Paula , Oliveira Raúl
Published: September 2024

Neck pain can induce specific motor responses and alterations in muscle strength. Therefore, this study aimed to investigate and compare the progression of cervical muscle strength within and between students with and without neck pain over the course of their first semester of clinical training. We used an online Nordic Musculoskeletal Questionnaire for group allocation, and neck strength in flexion, extension, and lateral flexion on both sides was measured using the KForce Bubble Pro hand-held dynamometer. Forty-four students were divided into neck pain (n = 21) and asymptomatic (n = 23) groups. Both groups increased neck strength by the end of the semester in flexion, extension, and left and right lateral flexion (p < 0.001). Students experiencing neck pain showed a significantly lesser degree of improvement (p = 0.036) in right lateral flexion. The agonist/antagonist ratios revealed an enhanced role of neck extensors across both groups. Dental students showed overall increased cervical strength in their first semester of clinical training. Those with neck pain exhibited a diminished rate of strength gain in right lateral flexion when compared with students without pain by the semester’s end, suggesting different neuromuscular adjustments to clinical practice in students experiencing pain, which may lead to functional impairments in later training stages.
A Novel Small-Scale Bladeless Wind Turbine Using Vortex-Induced Vibration and a Discrete Resonance-Shifting Module
Authors: Kang Heeyun , Kook Jinho , Lee Jaeyoung , Kim Young-Keun
Published: September 2024

The bladeless wind turbine (BWT) using vortex-induced vibration is a new class of wind turbine that does not have traditional rotating blades and converts wind energy into vibration energy and into electrical energy based on vortex-shedding principles. Since conventional BWTs are only efficient for a small range of wind speeds near the structural resonant frequency, this study proposes a novel bladeless wind turbine that can tune the resonant frequency for a wider range of wind speeds to improve the effective power generation region. This study designed a discrete on–off resonance-shifting module based on a smart material with variable stiffness that can easily tune the structural frequency of the BWT to two different wind speed classes to enhance power generation efficiency. Experiments were conducted to confirm that the designed BWT can shift the resonant frequency of the structure by 60% and can operate in the ranges of light breezes and gentle breezes. Furthermore, a series of experiments present the power generation effectiveness of the proposed BWT under these different wind speed conditions.
Influence of Weathering Cavities on the Structural Stability of the Yuanjue Grottos in Southwestern China Based on 3D Numerical Simulation
Authors: Li Bin , Luan Jinpeng , Luo Yinhua , Chen Jundian , Zhao Fuquan
Published: September 2024

The Yuanjue Grottos are representative of the sandstone grottos in southwest China. The structural stability of their wallrocks has suffered a certain degree of damage, resulting from weathering cavities, which seriously threatens the long-term preservation of these cultural relics. This study utilizes 3D numerical simulation to assess the impact of weathering cavity depth on the structural stability of the grottos. The results reveal that the presence of cavities has led to significant wallrock deformation and settlement, particularly in the front side of the entrance and baseplate area. As the cavity depth increases, the deformation effect intensifies. This study also characterizes the relationship between stress deformation and the distribution of weathered fissures, indicating that joint areas are more susceptible to spalling. Displacement monitoring indicates that the baseplate has experienced uplift, followed by settlement as the cavity depth increases, suggesting an initial phase of elastic deformation followed by plastic and brittle deformation stages, which is consistent with the numerical simulation results. Notably, the baseplate’s settlement trend was found to accelerate when the cavity depth exceeded 4 m, with significant changes being observed when the depth exceeded 5 m. Therefore, the depth of the weathering cavity beneath the entrance of the Yuanjue Grottos should be controlled within 5 m, in order to ensure their long-term stability. This research contributes to the understanding of the mechanisms affecting the structural stability of grottos and provides valuable insights for conservation efforts.
Multi-Label Classification for Predicting Antimicrobial Resistance on E. coli
Authors: Gidiglo Prince Delator , Ngnamsie Njimbouom Soualihou , Aly Abdelkader Gelany , Mosalla Soophia , Kim Jeong-Dong
Published: September 2024

Antimicrobial resistance (AMR) represents a pressing global health challenge with implications for developmental progress, as it increasingly manifests within pathogenic bacterial populations. This phenomenon leads to a substantial public health hazard, given its capacity to undermine the efficacy of medical interventions, thereby jeopardizing patient welfare. In recent years, an increasing number of machine learning methods have been employed to predict antimicrobial resistance. However, these methods still pose challenges in single-drug resistance prediction. This study proposed an effective model for predicting antimicrobial resistance to E. Coli by utilizing the eXtreme Gradient Boosting model (XGBoost), among ten other machine learning methods. The experimental results demonstrate that XGBoost outperforms other machine learning classification methods, particularly in terms of precision and hamming loss, with scores of 0.891 and 0.110, respectively. Our study explores the existing machine learning models for predicting antimicrobial resistance (AMR), thereby improving the diagnosis as well as treatment of infections in clinical settings.
An Investigation of the Effects of Thermo-Oxidative Aging and the Freeze–Thaw Cycle on the Performance of Polyester-Based, Self-Adhesive Asphalt Waterproofing Membranes
Authors: Tan Jun , Zhang Chao , Sun Guojun , Ma Xingpeng , Du Hongwei
Published: September 2024

Polyester-based, self-adhesive asphalt waterproofing membranes have garnered significant attention due to their extensive use in building-waterproofing projects, with their resistance to aging in complex environments being particularly crucial. This study evaluates the performance changes of these membranes under thermo-oxidative aging and freeze–thaw cycling conditions. The thermo-oxidative aging process was simulated using a thin-film oven and combined with freeze–thaw cycle tests to assess membrane performance at various aging stages. Changes in functional groups were analyzed via Fourier Transform Infrared Spectroscopy (FTIR), and tests for low-temperature flexibility, tensile properties, and peel strength were conducted. The results demonstrated that aging significantly reduced the membrane’s low-temperature flexibility and peel strength, accompanied by oxidative reactions and a loss of lightweight components. This study provides essential data on the aging behavior of the membrane and offers a theoretical foundation for its long-term application in practical engineering.
Automatic Era Identification in Classical Arabic Poetry
Authors: Makhoul Sleiman Nariman , Hussein Ali Ahmad , Kuflik Tsvi , Minkov Einat
Published: September 2024

The authenticity of classical Arabic poetry has long been challenged by claims that some part of the pre-Islamic poetic heritage should not be attributed to this era. According to these assertions, some of this legacy was produced after the advent of Islam and ascribed, for different reasons, to pre-Islamic poets. As pre-Islamic poets were illiterate, medieval Arabic literature devotees relied on Bedouin oral transmission when writing down and collecting the poems about two centuries later. This process left the identity of the real poets who composed these poems and the period in which they worked unresolved. In this work, we seek to answer the questions of how and to what extent we can identify the period in which classical Arabic poetry was composed, where we exploit modern-day automatic text processing techniques for this aim. We consider a dataset of Arabic poetry collected from the diwans (‘collections of poems’) of thirteen Arabic poets that corresponds to two main eras: the pre-ʿAbbāsid era (covering the period between the 6th and the 8th centuries CE) and the ʿAbbāsid era (starting in the year 750 CE). Some poems in each diwan are considered ‘original’; i.e., poems that are attributed to a certain poet with high confidence. The diwans also include, however, an additional section of poems that are attributed to a poet with reservations, meaning that these poems might have been composed by another poet and/or in another period. We trained a set of machine learning algorithms (classifiers) in order to explore the potential of machine learning techniques to automatically identify the period in which a poem had been written. In the training phase, we represent each poem using various types of features (characteristics) designed to capture lexical, topical, and stylistic aspects of this poetry. By training and assessing automatic models of period prediction using the ‘original’ poetry, we obtained highly encouraging results, measuring between 0.73–0.90 in terms of F1 for the various periods. Moreover, we observe that the stylistic features, which pertain to elements that characterize Arabic poetry, as well as the other feature types, are all indicative of the period in which the poem had been written. We applied the resulting prediction models to poems for which the authorship period is under dispute (‘attributed’) and got interesting results, suggesting that some of the poems may belong to different eras—an issue to be further examined by Arabic poetry researchers. The resulting prediction models may be applied to poems for which the authorship period is under dispute. We demonstrate this research direction, presenting some interesting anecdotal results.
The ‘Nature’ of Vertical School Design—An Evolving Concept
Authors: Duffy Alan J.
Published: September 2024

Successful urban school design includes green space to counterpoint the built form in cities, where parks and reserves are well frequented. Further integration of landscape and buildings is an aspect of urban development that could improve how architecture is experienced by the wider community. Above all, evidence shows that it enhances the health and wellbeing of inhabitants. By providing green space in buildings, nature can be accessed more directly by its occupants and allow connection with nature to occur more easily. Integrating nature with architecture can improve a building’s self-regulation, energy consumption, and overall performance. Architecture that integrates nature can have a distinctive appearance and character. The co-existence of bricks and mortar with plants and vegetation is one example of integration, whereas the use of natural materials such as timber as part of the building fabric can create distinctive architecture. It is this individuality that can provide a sense of identity to local communities. Access to the outdoors in urban settings is a critical requirement for successful urban school design. This paper focuses on the architectural practise of designing biophilic schools and illustrates how optimising playground opportunities can provide the highly sought-after connection between architecture and nature. Connecting classrooms and pedagogy to the outside environment during the design phases of projects can create unique responses to a place, enhancing the learning experience in environments where architecture and nature can be informed by emerging biophilic evidence. This study strives to develop a strategy where educational clients can be convinced to actively embrace a biophilic school approach. It also seeks to convince architects to adopt a biophilic approach to school design across design studios using the emerging evidence based on biophilia and biomimicry.
Analytical and Numerical Approaches via Quadratic Integral Equations
Authors: Alahmadi Jihan , Abdou Mohamed A. , Abdel-Aty Mohamed A.
Published: September 2024

A quadratic integral Equation (QIE) of the second kind with continuous kernels is solved in the space C([0,T]×[0,T]). The existence of at least one solution to the QIE is discussed in this article. Our evidence depends on a suitable combination of the measures of the noncompactness approach and the fixed-point principle of Darbo. The quadratic integral equation can be used to derive a system of integral equations of the second kind using the quadrature method. With the aid of two different polynomials, Laguerre and Hermite, the system of integral equations is solved using the collocation method. In each numerical approach, the estimation of the error is discussed. Finally, using some examples, the accuracy and scalability of the proposed method are demonstrated along with comparisons. Mathematica 11 was used to obtain all of the results from the techniques that were shown.
Lithium-Ion Battery Health Assessment Method Based on Double Optimization Belief Rule Base with Interpretability
Authors: Si Zeyang , Shen Jinting , He Wei
Published: September 2024

Health assessment is necessary to ensure that lithium-ion batteries operate safely and dependably. Nonetheless, there are the following two common problems with the health assessment models for lithium-ion batteries that are currently in use: inability to comprehend the assessment results and the uncertainty around the chemical reactions occurring inside the battery. A rule-based modeling strategy that can handle ambiguous data in health state evaluation is the belief rule base (BRB). In existing BRB studies, experts often provide parameters such as the initial belief degree, but the parameters may not match the current data. In addition, random global optimization methods may undermine the interpretability of expert knowledge. Therefore, this paper proposes a lithium-ion battery health assessment method based on the double optimization belief rule base with interpretability (DO-BRB-I). First, the belief degree is optimized according to the data distribution. Then, to increase accuracy, belief degrees and other parameters are further optimized using the projection covariance matrix adaptive evolution strategy (P-CMA-ES). At the same time, four interpretability constraint strategies are suggested based on the features of lithium-ion batteries to preserve interpretability throughout the optimization process. Finally, to confirm the efficacy of the suggested approach, a sample of the health status assessment of the B0006 lithium-ion battery is provided.
Computational Modeling Approach to Profile Hemodynamical Behavior in a Healthy Aorta
Authors: Al-Jumaily Ahmed M. , Al-Rawi Mohammad , Belkacemi Djelloul , Sascău Radu Andy , Stătescu Cristian , Țurcanu Florin-Emilian , Anghel Larisa
Published: September 2024

Cardiovascular diseases (CVD) remain the leading cause of mortality among older adults. Early detection is critical as the prognosis for advanced-stage CVD is often poor. Consequently, non-invasive diagnostic tools that can assess hemodynamic function, particularly of the aorta, are essential. Computational fluid dynamics (CFD) has emerged as a promising method for simulating cardiovascular dynamics efficiently and cost-effectively, using increasingly accessible computational resources. This study developed a CFD model to assess the aorta geometry using tetrahedral and polyhedral meshes. A healthy aorta was modeled with mesh sizes ranging from 0.2 to 1 mm. Key hemodynamic parameters, including blood pressure waveform, pressure difference, wall shear stress (WSS), and associated wall parameters like relative residence time (RRT), oscillatory shear index (OSI), and endothelial cell activation potential (ECAP) were evaluated. The performance of the CFD simulations, focusing on accuracy and processing time, was assessed to determine clinical viability. The CFD model demonstrated clinically acceptable results, achieving over 95% accuracy while reducing simulation time by up to 54%. The entire simulation process, from image construction to the post-processing of results, was completed in under 120 min. Both mesh types (tetrahedral and polyhedral) provided reliable outputs for hemodynamic analysis. This study provides a novel demonstration of the impact of mesh type in obtaining accurate hemodynamic data, quickly and efficiently, using CFD simulations for non-invasive aortic assessments. The method is particularly beneficial for routine check-ups, offering improved diagnostics for populations with limited healthcare access or higher cardiovascular disease risk.
Uncovering a Causal Connection between Gut Microbiota and Six Thyroid Diseases: A Two-Sample Mendelian Randomization Study
Authors: Chen Jiahao , Wang Yu , Yao Hang , Li Yuxin , Song Hong
Published: September 2024

Background: Recent studies have established associations between the gut microbiota (GM) and thyroid diseases (TDs). However, their causal relationships remain elusive. Methods: To investigate this causality, we conducted a two-sample Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data from MiBioGen and FinnGen, with GM as the exposure and six TDs as outcomes. Results: We identified 32 microbial taxa linked to the risk of six TDs. The Clostridium innocuum group, Ruminiclostridium5, and Lachnoclostridium exhibited protective effects against nontoxic diffuse goiter (NDG). Conversely, an increased risk of NDG was associated with Ruminococcaceae UCG002, Alistipes, Methanobrevibacter, Marvinbryantia, and Ruminococcaceae UCG014. Bifidobacterium and Sutterella were protective against nontoxic multinodular goiter (NMG), while the Ruminococcus gauvreauii group and Rikenellaceae RC9 gut group heightened NMG risk. Protective effects against nontoxic single thyroid nodule (NSTN) were observed with Defluviitaleaceae UCG011, Ruminococcus1, and Ruminococcaceae UCG010, whereas increased risk was linked to Alistipes, the Ruminococcus gauvreauii group, and Lachnospiraceae UCG010. Ruminiclostridium9, Victivallis, and Butyricimonas offered protection against thyrotoxicosis with Graves’ Disease (GD), while the Eubacterium rectale group, Desulfovibrio, Bifidobacterium, Collinsella, Oscillospira, and Catenibacterium were risk factors. For thyrotoxicosis with Plummer Disease (PD), protective taxa included Butyricimonas and Lachnospira, whereas Dorea, Eggerthella, Odoribacter, Lactobacillus, Intestinimonas, and Phascolarctobacterium increased risk. Lastly, Parasutterella was protective against thyrotoxicosis with toxic single thyroid nodule (TSTN), while increased risk was associated with Sutterella, Oscillibacter, and Clostridium sensu stricto1. Conclusions: Our findings support a causal relationship between specific GM and TDs at the genetic level, laying the foundation for future research into potential mechanisms and the identification of novel therapeutic targets.
Extracellular Vesicles: Diagnostic and Therapeutic Applications in Cancer
Authors: Di Bella Maria Antonietta , Taverna Simona
Published: September 2024

In recent years, knowledge of cell-released extracellular vesicle (EV) functions has undergone rapid growth. EVs are membrane vesicles loaded with proteins, nucleic acids, lipids, and bioactive molecules. Once released into the extracellular space, EVs are delivered to target cells that may go through modifications in physiological or pathological conditions. EVs are nano shuttles with a crucial role in promoting short- and long-distance cell–cell communication. Comprehension of the mechanism that regulates this process is a benefit for both medicine and basic science. Currently, EVs attract immense interest in precision and nanomedicine for their potential use in diagnosis, prognosis, and therapies. This review reports the latest advances in EV studies, focusing on the nature and features of EVs and on conventional and emerging methodologies used for their separation, characterization, and visualization. By searching an extended portion of the relevant literature, this work aims to give a summary of advances in nanomedical applications of EVs. Moreover, concerns that require further studies before translation to clinical applications are discussed.
Frequency-Domain Features and Low-Frequency Synchronization of Photoplethysmographic Waveform Variability and Heart Rate Variability with Increasing Severity of Cardiovascular Diseases
Authors: Kiselev Anton R. , Posnenkova Olga M. , Karavaev Anatoly S. , Shvartz Vladimir A. , Novikov Mikhail Yu. , Gridnev Vladimir I.
Published: September 2024

Objective—Heart rate variability (HRV) and photoplethysmographic waveform variability (PPGV) are available approaches for assessing the state of cardiovascular autonomic regulation. The goal of our study was to compare the frequency-domain features and low-frequency (LF) synchronization of the PPGV and HRV with increasing severity of cardiovascular diseases. Methods—Our study included 998 electrocardiogram (ECG) and finger photoplethysmogram (PPG) recordings from subjects, classified into five categories: 53 recordings from healthy subjects, aged 28.1 ± 6.2 years, 536 recordings from patients with hypertension (HTN), 49.0 ± 8.8 years old, 185 recordings from individuals with stable coronary artery disease (CAD) (63.9 ± 9.3 years old), 104 recordings from patients with myocardial infarction (MI) that occurred three months prior to the recordings (PMI) (65.1 ± 11.0 years old), and 120 recordings from study subjects with acute myocardial infarction (AMI) (64.7 ± 11.5 years old). Spectral analyses of the HRV and PPGV were carried out, along with an assessment of the synchronization strength between LF oscillations of the HRV and of PPGV (synchronization index). Results—Changes in all frequency-domain indices and the synchronization index were observed along the following gradient: healthy subjects → patients with HTN → patients with CAD → patients with PMI → patients with AMI. Similar frequency-domain indices of the PPGV and HRV show little relationship with each other. Conclusions—The frequency-domain indices of the PPGV are highly sensitive to the development of any cardiovascular disease and, therefore, are superior to the HRV indices in this regard. The S index is an independent parameter from the frequency-domain indices.
Video-Guided Optimization of Stimulation Settings in Patients with Parkinson’s Disease and Deep Brain Stimulation
Authors: Jergas Hannah , Steffen Julia K. , Schedlich-Teufer Charlotte , Strelow Joshua N. , Kramme Johanna , Fink Gereon R. , Visser-Vandewalle Veerle , Barbe Michael T. , Wirths Jochen
Published: September 2024

Deep brain stimulation (DBS) for Parkinson’s disease (PD) often necessitates frequent clinic visits for stimulation program optimization, with limited experience in remote patient management. Due to the resource-intensive nature of these procedures, we investigated a way to simplify stimulation optimization for these patients that allows for the continuous monitoring of symptoms while also reducing patient burden and travel distances. To this end, we prospectively recruited ten patients treated with DBS for PD to evaluate the feasibility of telemedicinal optimization in a home-based setting. Patients recorded daily videos of a modified Unified Parkinson’s Disease Rating Scale (UPDRS) III, which experienced DBS physicians located at the clinic assessed to provide instructions on adjusting stimulation settings using a handheld programmer with previously set programs as well as patient amplitude control. This study concluded with significant improvements in participants’ motor status as measured by the UPDRS-III (p = 0.0313) compared to baseline values. These findings suggest that remote video-guided optimization of DBS settings is feasible and may enhance motor outcomes for patients.
Consideration of Different Soil Properties and Roughness in Shear Characteristics of Concrete–Soil Interface
Authors: Wang Shihao , Ni Zhenqiang , Hou Fengzhan , Li Wenlan , Bing Long
Published: September 2024

To investigate the impact of diverse soil characteristics and surface irregularities on interfacial shear strength attributes, a large-scale straight shear apparatus and particle flow software were employed to conduct interfacial shear experiments with varying soil properties and surface irregularities. The results demonstrated that, under an identical R and normal stress conditions, the clay and silty clay shear stress–displacement curves exhibited strain softening, while the silt curve exhibited strain hardening. An increase in R can markedly enhance the peak shear strength at the interface, although a critical value exists beyond which this effect is no longer observed. The Rc is primarily contingent upon the soil properties. Numerical simulations demonstrate that the internal shear displacement and deformation resulting from the diverse soil properties are distinct. Clay particles are constituted of varying-sized particle aggregates that collectively resist shear. Silt particles resist shear through interfacial friction generated by shear. The practicality of Duncan and Clough’s constitutive model for interfacial shear with roughness influence is verified, and the constitutive model under strain hardening is modified.
Is End-Stage Renal Disease Tumor Suppressive? Dispelling the Myths
Authors: Migita Toshiro
Published: September 2024

The prevalence of end-stage renal disease is increasing worldwide. Malignancies accompanying end-stage renal disease are detected in approximately 120 individuals per 10,000 person-years. Most studies have suggested that end-stage renal disease causes carcinogenesis and promotes tumor development; however, this theory remains questionable. Contrary to the theory that end-stage renal disease is predominantly carcinogenic, recent findings have suggested that after controlling for biases and sampling errors, the overall cancer risk in patients with end-stage renal disease might be lower than that in the general population, except for renal and urothelial cancer risks. Additionally, mortality rates associated with most cancers are lower in patients with end-stage renal disease than in the general population. Several biological mechanisms have been proposed to explain the anticancer effects of end-stage renal disease, including premature aging and senescence, enhanced cancer immunity, uremic tumoricidal effects, hormonal and metabolic changes, and dialysis therapy-related factors. Despite common beliefs that end-stage renal disease exacerbates cancer risk, emerging evidence suggests potential tumor-suppressive effects. This review highlights the potential anticancer effects of end-stage renal disease, proposing reconsideration of the hypothesis that end-stage renal disease promotes cancer development and progression.
Adrenal Insufficiency following Stereotactic Ablative Radiotherapy (SAbR) of Adrenal Gland Metastases
Authors: Hamidi Oksana , Miljanic Mihailo , Tumyan Gayane , Christie Alana , Mirfakhraee Sasan , Ali Sadia , Dohopolski Michael , Gottumukkala Sujana , Brugarolas James , Timmerman Robert , Hannan Raquibul
Published: September 2024

Background: Adrenal metastases are often treated with stereotactic ablative radiation (SAbR). We aimed to assess the incidence, timing, and factors associated with the development of primary adrenal insufficiency (PAI) following SAbR. Methods: A retrospective cohort study comprised 66 consecutive patients (73% men, median age 61 years) who underwent SAbR for adrenal metastasis. Results: The series encompassed metastases from renal cell carcinoma (41%), lung tumors (38%), colorectal adenocarcinoma (9%), melanoma (5%), and others (7%). Median follow-up was 17 months from SAbR. Nine (14%) patients developed PAI at a median of 4.3 months (range, 0.7–20.2). The incidence of PAI was 44% in patients with prior adrenalectomy receiving unilateral SAbR, 44% with bilateral SAbR, 2% with unaffected contralateral gland, and 0% with bilateral metastases treated with unilateral SAbR. PAI was associated with prior adrenalectomy (odds ratio [OR] 32) and bilateral SAbR (OR 8.2), but not age, sex, metastasis size, or biological effective dose. Post-SAbR 6-month and 1-year local control rates were 82% and 75%, respectively. Conclusions: Patients undergoing SAbR for adrenal metastasis are at high risk of developing PAI. PAI is associated with bilateral SAbR and contralateral adrenalectomy. PAI is unlikely with a remaining unaffected adrenal gland or in the setting of bilateral adrenal metastases with unilateral SAbR.
Immunotherapy for Parkinson’s Disease and Alzheimer’s Disease: A Promising Disease-Modifying Therapy
Authors: Mahboob Anns , Ali Hasan , AlNaimi AlJazi , Yousef Mahmoud , Rob Mlaak , Al-Muhannadi Nawaf Ahmad , Senevirathne Degiri Kalana Lasanga , Chaari Ali
Published: September 2024

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two neurodegenerative diseases posing a significant disease burden due to their increasing prevalence and socio-economic cost. Traditional therapeutic approaches for these diseases exist but provide limited symptomatic relief without addressing the underlying pathologies. This review examines the potential of immunotherapy, specifically monoclonal antibodies (mAbs), as disease-modifying treatments for AD and PD. We analyze the pathological mechanisms of AD and PD, focusing on the roles of amyloid-beta (Aβ), tau (τ), and alpha-synuclein (α-syn) proteins. We discuss the latest advancements in mAb therapies targeting these proteins, evaluating their efficacy in clinical trials and preclinical studies. We also explore the challenges faced in translating these therapies from bench to bedside, including issues related to safety, specificity, and clinical trial design. Additionally, we highlight future directions for research, emphasizing the need for combination therapies, improved biomarkers, and personalized treatment strategies. This review aims to provide insights into the current state and future potential of antibody-based immunotherapy in modifying the course of AD and PD, ultimately improving patient outcomes and quality of life.
C1orf106 (INAVA) Is a SMAD3-Dependent TGF-β Target Gene That Promotes Clonogenicity and Correlates with Poor Prognosis in Breast Cancer
Authors: Strathearn Lauren S. , Spender Lindsay C. , Schoenherr Christina , Mason Susan , Edwards Ruaridh , Blyth Karen , Inman Gareth J.
Published: September 2024

Transforming Growth Factor-β (TGF-β) can have both tumour-promoting and tumour-suppressing activity in breast cancer. Elucidating the key downstream mediators of pro-tumorigenic TGF-β signalling in this context could potentially give rise to new therapeutic opportunities and/or identify biomarkers for anti-TGF-β directed therapy. Here, we identify C1orf106 (also known as innate immunity activator INAVA) as a novel TGF-β target gene which is induced in a SMAD3-dependent but SMAD2/SMAD4-independent manner in human and murine cell lines. C1orf106 expression positively correlates with tumourigenic or metastatic potential in human and murine breast cancer cell line models, respectively, and is required for enhanced migration and invasion in response to TGF-β stimulation. C1orf106 promoted self-renewal and colony formation in vitro and may promote tumour-initiating frequency in vivo. High C1orf106 mRNA expression correlates with markers of aggressiveness and poor prognosis in human breast cancer. Taken together, our findings indicate that C1orf106 may act as a tumour promoter in breast cancer.
Adapting Child Development Assessment Tools to the Rural Indian Context
Authors: Chandrashekhar Riti , Dhaliwal Baldeep K. , Rattani Ananya , Seth Rajeev , Guruprasad Suba , Khanna Himani , Shet Anita
Published: September 2024

Background: Child development assessment tests serve many purposes, including educational placement, identifying cognitive weaknesses, and initiating early interventions. Much of the research associated with developmental testing has been conducted in high-income countries, offering limited guidance on adapting these tests to other settings. Objectives: As part of the first phase of a study exploring the impact of childhood vaccines on cognition and school attainment, we aimed to assess the feasibility of enrolling children from the community, documenting immunization, and conducting child development assessments for children between 18 months and 8 years of age in a rural setting in Haryana, India. Methods: To ensure assessments are optimally tailored to the context, child development assessment tests require valid translation and cultural adaptation. This report describes the rigorous seven-step adaptation process we designed for the contextually appropriate adaptation of the following three child development assessment tests: the Bayley Scales of Infant Development-IV, the Stanford Binet Intelligence Scale Fifth Ed. for Early Childhood, and the Wechsler Intelligence Scale for Children IV. Results: This process involved translating tests into the local language, back-translating them for accuracy, adapting them to the rural context via several iterations, and field-testing to refine and validate adaptation quality. Conclusions: This adaptation process may be beneficial for other researchers involved in adapting child development assessment tests to other settings. Further, this adaptation process may inform other researchers involved in adapting tests for diverse settings.
Assessment of Motor Performance and Self-Perceived Psychophysical Well-Being in Relation to Body Mass Index in Italian Adolescents
Authors: Altavilla Gaetano , Aliberti Sara , D’Elia Francesca
Published: September 2024

Background/Objectives: The relationship between psychophysical self-perception (PSP), body mass index (BMI) and motor performance (MP) levels, in quantitative and qualitative terms, can be a very interesting connection to investigate. This study aimed to assess MP and PSP according to gender and weight differences (normal weight—Nw/overweight–obese—Ov-Ob) and their relationship to BMI in Italian adolescents. Methods: In total, 144 students (F = 72; M = 72) aged between 11 and 13 y.o. participated in this study. They were divided into two groups by gender and into two subgroups based on weight (Nw/Ov-Ob). Standing long jump, sit-and-reach, 10 × 5 m shuttle and sit-up tests to assess MP were carried out, and an ad hoc questionnaire to evaluate PSP was administrated. Results: In comparing the Nw and Ov-Ob subgroups on the basis of BMI for each gender, statistically significant differences emerged in all motor skill tests administered. Regarding PSP, the Nw subgroup showed high and positive levels, while Ov-Ob showed low and negative levels, highlighting a relationship between high BMI and poor motor performance as well as negative psychophysical perception in the Ov-Ob subgroup. Conclusions: this study supports the importance of physical sport activity to regulate excess weight but also contribute to better psychophysical well-being.
Enhancing Telemedicine Communication for Improved Outpatient Pediatric Trauma Care
Authors: Mokhaberi Nariman , Schoof Benjamin , Strahl André , Reinshagen Konrad , Wintges Kristofer
Published: September 2024

Introduction. Pediatric traumatology is a complex field that requires a comprehensive understanding of physeal development, remodeling potential, and the ossification process in order to ensure appropriate patient treatment. The objective of this study was to assess the willingness of practicing physicians to participate in a telemedicine collaboration aimed at enhancing the exchange between the outpatient and inpatient sectors and promoting the digitalization of the pediatric sector. This is in response to the growing significance of digitalization in the medical field. Methods. A survey consisting of 15 items was sent to 800 practicing trauma surgeons, pediatric surgeons, and pediatricians within a 100 km radius of Hamburg, Germany. The survey included questions about the respondents’ professional experience and telemedicine experience, as well as inquiries about possible telemedicine collaborations. Results. The response rate was 19.3%. Less than half of the participants already used telemedicine in daily practice. In general, 75% of respondents expressed an interest in collaborating with the inpatient sector. The most common reasons for hospital referral were the need for surgery, inadequate treatment of children in practice and co-assessment. The majority were in favor of flexible communication, either via video telephony, imaging applications like or messaging applications. Conclusions. The study revealed a high level of interest in telemedicine collaboration. Information exchange should be tailored to individual needs, with practitioners requiring a versatile and personalized approach that includes imaging. Strict enforcement of data protection regulations is essential. Further research is needed to evaluate the effectiveness of telemedicine collaboration in the treatment of pediatric trauma in both hospital and outpatient settings.
Disulfidptosis: A New Target for Parkinson’s Disease and Cancer
Authors: Liu Tingting , Kong Xiangrui , Wei Jianshe
Published: September 2024

Recent studies have uncovered intriguing connections between Parkinson’s disease (PD) and cancer, two seemingly distinct disease categories. Disulfidptosis has garnered attention as a novel form of regulated cell death that is implicated in various pathological conditions, including neurodegenerative disorders and cancer. Disulfidptosis involves the dysregulation of intracellular redox homeostasis, leading to the accumulation of disulfide bonds and subsequent cell demise. This has sparked our interest in exploring common molecular mechanisms and genetic factors that may be involved in the relationship between neurodegenerative diseases and tumorigenesis. The Gene4PD database was used to retrieve PD differentially expressed genes (DEGs), the biological functions of differential expression disulfidptosis-related genes (DEDRGs) were analyzed, the ROCs of DEDRGs were analyzed using the GEO database, and the expression of DEDRGs was verified by an MPTP-induced PD mouse model in vivo. Then, the DEDRGs in more than 9000 samples of more than 30 cancers were comprehensively and systematically characterized by using multi-omics analysis data. In PD, we obtained a total of four DEDRGs, including ACTB, ACTN4, INF2, and MYL6. The enriched biological functions include the regulation of the NF-κB signaling pathway, mitochondrial function, apoptosis, and tumor necrosis factor, and these genes are rich in different brain regions. In the MPTP-induced PD mouse model, the expression of ACTB was decreased, while the expression of ACTN4, INF2, and MYL6 was increased. In pan-cancer, the high expression of ACTB, ACTN4, and MYL6 in GBMLGG, LGG, MESO, and LAML had a poor prognosis, and the high expression of INF2 in LIHC, LUAD, UVM, HNSC, GBM, LAML, and KIPAN had a poor prognosis. Our study showed that these genes were more highly infiltrated in Macrophages, NK cells, Neutrophils, Eosinophils, CD8 T cells, T cells, T helper cells, B cells, dendritic cells, and mast cells in pan-cancer patients. Most substitution mutations were G-to-A transitions and C-to-T transitions. We also found that miR-4298, miR-296-3p, miR-150-3p, miR-493-5p, and miR-6742-5p play important roles in cancer and PD. Cyclophosphamide and ethinyl estradiol may be potential drugs affected by DEDRGs for future research. This study found that ACTB, ACTN4, INF2, and MYL6 are closely related to PD and pan-cancer and can be used as candidate genes for the diagnosis, prognosis, and therapeutic biomarkers of neurodegenerative diseases and cancers.
Impacts of DROSHA (rs10719) and DICER (rs3742330) Variants on Breast Cancer Risk and Their Distribution in Blood and Tissue Samples of Egyptian Patients
Authors: Shaalan Aly A. M. , Al Ageeli Essam , Kattan Shahad W. , Almars Amany I. , Babteen Nouf A. , Sindi Abdulmajeed A. A. , Toraih Eman A. , Fawzy Manal S. , Mohamed Marwa Hussein
Published: September 2024

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression and play critical roles in tumorigenesis. Genetic variants in miRNA processing genes, DROSHA and DICER, have been implicated in cancer susceptibility and progression in various populations. However, their role in Egyptian patients with breast cancer (BC) remains unexplored. This study aims to investigate the association of DROSHA rs10719 and DICER rs3742330 polymorphisms with BC risk and clinical outcomes. This case–control study included 209 BC patients and 106 healthy controls. Genotyping was performed using TaqMan assays in blood, tumor tissue, and adjacent non-cancerous tissue samples. Associations were analyzed using logistic regression and Fisher’s exact test. The DROSHA rs10719 AA genotype was associated with a 3.2-fold increased risk (95%CI = 1.23–9.36, p < 0.001), and the DICER rs3742330 GG genotype was associated with a 3.51-fold increased risk (95%CI = 1.5–8.25, p = 0.001) of BC. Minor allele frequencies were 0.42 for rs10719 A and 0.37 for rs3742330 G alleles. The risk alleles were significantly more prevalent in tumor tissue than adjacent normal tissue (rs10719 A: 40.8% vs. 0%; rs3742330 G: 42.7% vs. 0%; p < 0.001). However, no significant associations were observed with clinicopathological features or survival outcomes over a median follow-up of 17 months. In conclusion, DROSHA rs10719 and DICER rs3742330 polymorphisms are associated with increased BC risk and more prevalent in tumor tissue among our cohort, suggesting a potential role in miRNA dysregulation during breast tumorigenesis. These findings highlight the importance of miRNA processing gene variants in BC susceptibility and warrant further validation in larger cohorts and different ethnic populations.
Musculoskeletal Disorders in the Clinical Practice of Dental Hygienists and Dentists, Prevention and Awareness among Italian Professionals: Focus on Enlarging Systems
Authors: Butera Andrea , Maiorani Carolina , Fantozzi Giulia , Bergamante Francesca , Castaldi Matteo , Grassi Roberta , Leuter Cinzia , Scribante Andrea , Nardi Gianna Maria
Published: September 2024

(1) Background: Musculoskeletal disorders of the upper limbs are a common medical condition among dental hygienists and dentists, making them a common occupational risk for dental professionals. The purpose of the work was to collect information about the dental professions and their habits to highlight what can be good practices to be carried out to prevent any musculoskeletal disorders. (2) Methods: To identify habits and problems inherent in the professional activity of dental hygienists and dentists, a questionnaire was formulated on the use of enlarging systems. (3) Results: The questionnaire was completed by 241 dental professionals. As for the use of magnifiers, 72.6% of participants use them: among dental hygienists, 67.8% use magnifiers, among dentists, 80.9% use magnifiers; there is a statistically significant difference. There is no statistically significant difference between professions regarding muscle disorders. (4) Conclusions: For a clearer assessment, it would be appropriate to submit the questionnaire to a wider sample of professionals, to define better the correlation between musculoskeletal disorders, work activity and the type of enlarging systems used.