bluuebunny/crossref_metadata_2025 huggingface dataset:
Gut microbiome and serum short-chain fatty acids are associated with responses to chemo- or targeted therapies in Chinese patients with lung cancer
Authors: Chen Huan-Huan , Wu Qi-Jun , Zhang Tie-Ning , Zhao Yu-Hong
Published: July 2023

Background

The association between gut microbes and short-chain fatty acids (SCFAs) and therapeutic responses of patients with lung cancer (LC) receiving therapy remains unknown.

Methods

Fecal and serum samples were prospectively collected from patients with LC, classified as responders, if they presented durable clinical benefits, and non-responders, if not. The composition of gut microbes was analyzed using 16S ribosomal DNA sequencing. Serum SCFA concentrations were detected using gas chromatography. Cell proliferation, migration, invasion, cell cycle, and apoptosis assays were performed on isobutyric acid-treated A549 cells. Reverse transcription-quantitative PCR, Western blotting, immunocytochemistry, and immunofluorescence staining experiments have been performed to investigate the expression of associated genes or proteins.

Results

Non-responders harbored higher microbiome α-diversity but lower β-diversity compared with responders. Compared to the patients with low α-diversity, those with high α-diversity showed significantly shorter progression-free survival. Additionally, β-diversity has also been observed between these two groups. Specifically, Parasutterella, Clostridiaceae, and Prevotella_7 were more abundant among responders, whereas Bacteroides_stercoris and Christensenellaceae_R-7_group were more abundant in non-responders. The serum SCFA (especially acetate and isobutyrate) levels tended to be higher in responders. Isobutyric acid inhibited the proliferation, migration, and invasion of A549 cells by inducing apoptosis and G1/S arrest while upregulating the expression of GPR41, GPR43, and GPR5C and downregulating that of PAR1, and increasing the activity of histone acetyltransferases.

Conclusion

We revealed the influence of gut microbiota and SCFAs on the therapeutic responses in patients with LC and the anti-tumor effect of isobutyric acid, indicating their potential use as therapeutic targets.
Novel computational and drug design strategies for inhibition of monkeypox virus and Babesia microti: molecular docking, molecular dynamic simulation and drug design approach by natural compounds
Authors: Akash Shopnil , Mir Showkat Ahmad , Mahmood Sajjat , Hossain Saddam , Islam Md. Rezaul , Mukerjee Nobendu , Nayak Binata , Nafidi Hiba-Allah , Bin Jardan Yousef A. , Mekonnen Amare , Bourhia Mohammed
Published: July 2023

Background

The alarming increase in tick-borne pathogens such as human Babesia microti is an existential threat to global public health. It is a protozoan parasitic infection transmitted by numerous species of the genus Babesia. Second, monkeypox has recently emerged as a public health crisis, and the virus has spread around the world in the post-COVID-19 period with a very rapid transmission rate. These two novel pathogens are a new concern for human health globally and have become a significant obstacle to the development of modern medicine and the economy of the whole world. Currently, there are no approved drugs for the treatment of this disease. So, this research gap encourages us to find a potential inhibitor from a natural source.

Methods and materials

In this study, a series of natural plant-based biomolecules were subjected to in-depth computational investigation to find the most potent inhibitors targeting major pathogenic proteins responsible for the diseases caused by these two pathogens.

Results

Among them, most of the selected natural compounds are predicted to bind tightly to the targeted proteins that are crucial for the replication of these novel pathogens. Moreover, all the molecules have outstanding ADMET properties such as high aqueous solubility, a higher human gastrointestinal absorption rate, and a lack of any carcinogenic or hepatotoxic effects; most of them followed Lipinski’s rule. Finally, the stability of the compounds was determined by molecular dynamics simulations (MDs) for 100 ns. During MDs, we observed that the mentioned compounds have exceptional stability against selected pathogens.

Conclusion

These advanced computational strategies reported that 11 lead compounds, including dieckol and amentoflavone, exhibited high potency, excellent drug-like properties, and no toxicity. These compounds demonstrated strong binding affinities to the target enzymes, especially dieckol, which displayed superior stability during molecular dynamics simulations. The MM/PBSA method confirmed the favorable binding energies of amentoflavone and dieckol. However, further in vitro and in vivo studies are necessary to validate their efficacy. Our research highlights the role of Dieckol and Amentoflavone as promising candidates for inhibiting both monkeypox and Babesia microti, demonstrating their multifaceted roles in the control of these pathogens.
Developing a recovery-oriented intervention for people with severe mental illness and an intellectual disability: design-oriented action research
Authors: Berger Ingeborg , Bruineberg Anne , van Ewijk Margot , de Jong Levi , van der Hout Michiel , van Weeghel Jaap , van der Meer Lisette
Published: July 2023

Introduction

Mild intellectual disability or borderline intellectual functioning (MID/BIF) are common in people with severe mental health problems (SMHP). Despite this, there is a lack of treatments adapted for this group of clients.

Methods

This qualitative study describes the development of a new intervention, guided by the principles of action research, for people with SMHP and MID/BIF and mental health professionals to help them talk about all aspects of the process of recovery. The intervention was developed in four cycles and in close cooperation with mental health professionals, experts by experience, other experts in the field of SMHP or MID/BIF, and clients. During all cycles there was a strong focus on the content of the intervention, exercises, understandable language, and drawings for visual support.

Results

This resulted in the intervention “Routes to Recovery,” which covers both complaints and strengths, coping strategies, helpful (social) activities, and how to determine future steps in a recovery plan.

Discussion

Routes to Recovery is a first step in helping professionals and their clients with SMHP and MID/BIF to have a conversation about personal strengths and what the client needs to recover. Future research should investigate the effects of this intervention.
Physics-Guided Neural Network Model for Aeroengine Control System Sensor Fault Diagnosis under Dynamic Conditions
Authors: Li Huihui , Gou Linfeng , Li Huacong , Liu Zhidan
Published: July 2023

Sensor health assessments are of great importance for accurately understanding the health of an aeroengine, supporting maintenance decisions, and ensuring flight safety. This study proposes an intelligent framework based on a physically guided neural network (PGNN) and convolutional neural network (CNN) to diagnose sensor faults under dynamic conditions. The strength of the approach is that it integrates information from physics-based performance models and deep learning models. In addition, it has the structure of prediction–residual–generation-fault classification that effectively decouples the interaction between sensor faults and system state changes. First, a PGNN generates the engine’s non-linear dynamic prediction output because the PGNN has the advantage of being able to handle temporal information from the long short-term memory (LSTM) network. We use a cross-physics–data fusion scheme as the prediction strategy to explore the hidden information of the physical model output and sensor measurement data. A novel loss function that considers physical discipline is also proposed to overcome the performance limitations of traditional data-driven models because of their physically inconsistent representations. Then, the predicted values of the PGNN are compared with the sensor measurements to obtain a residual signal. Finally, a convolutional neural network (CNN) is used to classify faults for residual signals and deliver diagnostic results. Furthermore, the feasibility of the proposed framework is demonstrated on an engine sensor fault dataset. The experimental results show that the proposed method outperforms the pure data-driven approach, with the predicted RMSE being reduced from 1.6731 to 0.9897 and the diagnostic accuracy reaching 95.9048%, thereby confirming its superior performance.
Learning from Forest Trees: Improving Urban Tree Biomass Functions
Authors: Vonderach Christian , Akontz Adrienne
Published: July 2023

Trees are one of the few carbon sinks in urban areas. Different methods are available to assess the biomass of urban trees, one of these being allometric biomass functions. Biomass functions are well investigated, reliable and easy to apply if the required information is available. Our goal is to use biomass functions to enhance urban forest management tools with information on stored biomass and carbon. In this study, we test several approaches to estimate new species-specific biomass functions. We include data from urban and traditional forest trees since both origins can be modeled by the allometric relationship solely giving different parameter estimates. The tested models include mixed allometric models for urban trees only, the adjustments of available forest tree biomass models and a cross-classified mixed model (CCMM) using both data from urban and forest trees. We then show by cross validation that the CCMM, statistically separating the data into different species and origins, shows greater improvement over the simpler models. Hence, we state that the inclusion of forest tree data improves the performance on biomass predictions for urban trees: the urban tree biomass functions “learned from forest trees”. The CCMM is also compared against the predictions of the above-ground biomass functions applied in the German National Forest Inventory. Comparable RMSE and slightly lower BIAS values are found, both for deciduous and coniferous tree species. With the approach of a cross-classified model, we also enable predictions for non-observed conifers in urban space, assuming comparable growth differences between deciduous and conifer species in forest stands and urban areas. A sample application using the CCMM model shows results for a small subset of data of an urban tree inventory, collected in a residential area in the city of Munich, Germany. It is applied to estimate carbon storage at two points in time and, hence, carbon fluxes in the period under consideration. Such information can help in the decision making and management of urban trees.
Experience in creating a unique image of the hotel
Authors:   Graduate School of Management Russian Economic University G. V. Plekhanov, Rybkina E. V.
Published: July 2023

The article discusses the experience of the art hotel "StandArt", the main feature of which is an unusual futuristic design. An important task of this enterprise is to create a unique interior and style that can attract many customers and leave memorable impressions.
The current state of development of international tourism
Authors:   Federal State Budgetary Educational Institution of Higher Education Russian University of Economics G. V. Plekhanov, Panova E. A.
Published: July 2023

Over the past two decades, tourism has become one of the most profitable sectors of the world economy. The last three years for the development of international tourism have been difficult. 2020–2021 were problematic due to the global COVID-19 pandemic. In 2022, there was a rapid increase in international tourism, but this growth was complicated by military operations on the territory of Ukraine and restrictions imposed on Russia. The article discusses the importance of tourism for the world economy and for national economies.
Long-Term Use of Non-Steroidal Anti-Inflammatory Drugs in Patients with Axial Spondyloarthritis to Suppress Acute Bone Marrow Inflammation in the Sacroiliac Joints
Authors:   V.A. Nasonova Research Institute of Rheumatology, Kurbanmagomedov M.K. , Starkova A.S. , Erdes Sh.F.
Published: July 2023

Long-term use of nonsteroidal anti-inflammatory drugs in daily therapeutic practice is not welcome and often causes rejection due to the potential for the development of a variety of adverse events. However, in axial spondyloarthritis, these drugs play the role of not only symptomatic therapy, but also modify the course of the disease. Therefore, they should be prescribed for a long period, much longer than that described in the instructions for the drug. A brief description of clinical cases of the use of various non-steroidal anti-inflammatory drugs lasting 3 or more months is presented. Against the background of good clinical efficacy, adverse events did not develop during many months of continuous use
Optimal Management of Comorbid Patients with Spondyloarthritis: Focus on Cardiovascular Safety
Authors:   Moscow Regional Research and Clinical Institute, Karateev D.E. , Luchikhina E.L. , Markelova E.I.
Published: July 2023

Comorbidity and multimobidity are typical for rheumatic diseases (RD) in general. Comorbidities have a complex negative impact on the patient with RD: they are often a direct cause of the premature death of patients, they may contribute to the severe course of the inflammatory process, comorbidities reduce choice of treatment options. Spondyloarthritis, such as psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), is also characterized by the frequent presence of comorbid conditions, in particular, cardiovascular diseases. Pleiotropic effects of pro-inflammatory cytokines such as interleukin 17A (IL-17A) promote these processes. IL-17A is a versatile pro-inflammatory T cell cytokine. At the same time, there is evidence that IL-17 involved in many other pathological processes: bone tissue remodeling, the development of endothelial dysfunction, formation of the unstable atherosclerotic plaques, heart ventricle remodeling after ischemic attack, etc. Clinical data confirm the role of hyperproduction of IL-17A in the development of cardiovascular diseases. On the example of Secukinumab IL-17A inhibition in PsA and axSpA, it has been shown that this treatment is associated with a high level of cardiovascular safety, and it is likely may help reduce cardiovascular risk. Therapy with IL-17A inhibitors, in particular, Secukinumab, in combination with generally accepted methods of correction of traditional cardiovascular risk factors, may be a promising direction in the management of patients with SpA and concomitant cardiovascular diseases
Planejamento e operacionalização de atividade de educação em saúde com gestantes na Atenção Primária à Saúde
Authors: Chini Lucélia Terra , Morasco Silvana de Souza Oliveira , Da Silva Tatiana Corrêa , Franco Anna Paula Mendes Marques de Lima , Leonel Gabriela Aparecida , Ramos Semirames Cartonilho de Souza , Freitas Patrícia Scotini
Published: July 2023

Introdução: o desenvolvimento de grupos de gestantes na atenção primária pode ser uma estratégia efetiva para promover o autocuidado, a educação em saúde e o compartilhamento de experiências entre as mulheres grávidas. Objetivo: relatar a experiência sobre o planejamento e operacionalização de uma atividade de educação em saúde com um grupo de gestantes de uma unidade de equipe de Saúde da Família (eSF). Método: trata-se de um relato de experiência sobre a realização de ações educativas por meio de grupos para gestantes cadastradas em uma unidade de eSF, desenvolvida por discentes do curso de graduação em enfermagem. Os encontros do grupo de gestantes ocorreram em seis semanas, nos quais foram abordadas as seguintes temáticas: alterações fisiológicas da gestação, cuidados com o recém-nascido, direitos das gestantes e puérperas, sexualidade na gestação, plano de parto e sobre cuidados e implicações da COVID-19 no ciclo gravídico puerperal. Resultados: a adesão aos grupos foi considerada satisfatória, contando com a participação de seis a 15 gestantes. Conclusão: os grupos de gestantes realizados desempenharam um papel fundamental como ferramenta de educação em saúde, oferecendo um ambiente de apoio e troca de informações essenciais para as gestantes e como estratégias de aprimoramento das competências profissionais dos acadêmicos em relação à assistência de enfermagem às gestantes.
Practical Tracking Method based on Best Buddies Similarity
Authors: He Haiyu , Chen Zhen , Liu Haikuo , Liu Xiangdong , Guo Youguang , Li Jian
Published: July 2023

Visual tracking is a crucial skill for bionic robots to perceive the environment and control their movement. However, visual tracking is challenging when the target undergoes nonrigid deformation because of the perspective change from the camera mounted on the robot. In this paper, a real-time and scale-adaptive visual tracking method based on best buddies similarity (BBS) is presented, which is a state-of-the-art template matching method that can handle nonrigid deformation. The proposed method improves the original BBS in 4 aspects: (a) The caching scheme is optimized to reduce the computational overhead, (b) the effect of cluttered backgrounds on BBS is theoretically analyzed and a patch-based texture is introduced to enhance the robustness and accuracy, (c) the batch gradient descent algorithm is used to further speed up the method, and (d) a resample strategy is applied to enable the BBS to track the target in scale space. The proposed method on challenging real-world datasets is evaluated and its promising performance is demonstrated.
AN OBSERVATIONAL STUDY OF THE ROLE OF IMMUNOHISTOCHEMISTRY IN THE ANALYSIS OF MALIGNANT SMALL ROUND CELL TUMORS
Authors: Kumar Sharma Rajendra , Gandhi Sapna , Meel Mukta , Kumar Nehra Anil , Kumar Upadhay Tapendra , Barman Shrabani
Published: July 2023

Background: Small round cell tumors (SRCT) are heterogeneous malignancies featuring primitive undifferentiated small cell morphology and describe the group of highly aggressive malignant tumors composed of relatively small and monotonous undifferentiated cells with increased nuclear-cytoplasmic ratio. Immunohistochemistry (IHC) has emerged as the most practical adjunct tool to histopathology making accurate diagnosis possible. To study the role of Immunohistochemistry in the analysis of ma Aim: Objectives:- lignant small round-cell tumors. (1) To study the importance of immunohistochemistry prole in malignant small round cell tumors. (2) Categorize the malignant small round cell tumors by Immunohistochemistry. (3)To know the age and sex incidence of malignant small round cell tumors. (4) To correlate histopathological and IHC features. Total 90 cases had been reported as Malignant Round Cell Tumor on biopsy.duri Materials and Methods: ng the study period 2021-22. Biopsy tissues/ samples were xed, parafn embedded, sectioned and, stained with hematoxylin and eosin. IHC was performed on each case. Results were analyzed and compared. Out of 90 cases, There were 31 cases(34.4%) of Results: Small Cell Carcinoma with the highest incidence, followed by 28 cases (31.1%) of Non-Hodgkin's lymphoma, Synovial Sarcoma 10 cases (11.1%), Ewings Sarcoma 8 cases(8.9%),Neuroblastoma 5 cases(5.6%), Malignant Melanoma 4 cases (4.4%), Rhabdomyosarcoma 3 cases(3.3%) and 1 case of Wilms Tumor. Malignant Conclusion :- Small Round Cell Tumors comprise a wide range of Heterogeneous group of Tumors. On light microscopy, these tumors have the basic morphologic themes of small round blue cells. In the diagnosis of Malignant small Round Cell Tumors, , light microscopic ndings is basic but not exact categorization done in many Undifferentiated Tumors. For diagnosis and exact categorization Immunohistochemistry are all taken into consideration. Immunohistochemical marker study has a great role of categorizing these tumors and accurate diagnosis is made possible which enable the patients to get the appropriate treatment and for better Prognosis
Análise do grau de conformidade legal dos dados de execução orçamentária nos portais de transparência municipais
Authors: Alves do Nascimento Vanessa , Souza Leal Ana Paula , De Sousa Almeida Bruno , Da Paixão Melo Jéssica , Sato de Souza Leonardo , Santos Saldanha Mateus , Scaravatti Paula
Published: July 2023

O objetivo do artigo é analisar as plataformas de transparência das capitais brasileiras municipais com o intuito de verificar o grau de conformidade legal dos dados orçamentários desses portais, verificando se os dados obrigatórios e recomendados dispostos em legislação  estão disponíveis. Para a análise, foi elaborado template de conformidade, verificando dados técnicos do site, itens de detalhamento de despesas e receitas, procedimentos licitatórios e informações financeiras publicadas, como Plano Plurianual, Lei de Diretrizes Orçamentárias, Balanços entre outros. Por fim, conforme análise desenvolvida, observou-se que a conformidade legal seguida pelos municípios para disponibilização de dados orçamentários é baixa, comprometendo o acesso da população às informações previstas em lei.
Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition
Authors: BELHAN Saadet , ÇİBUK Salih , KÖMÜROĞLU Ahmet Ufuk , ALTINDAĞ Fikret , DEĞER Yeter
Published: July 2023

The study was conducted to investigate how Ferula rigidula extract affected sperm profile, antioxidant parameters, and stereological profile in experimental diabetic rats. Performed on forty-nine male rats. The rats were randomly assigned to control group, diabetic group, diabetic + Ferula rigidula group 1, diabetic + Ferula rigidula group 2, diabetic + glibenclamide group, Ferula rigidula group 1, and Ferula rigidula group 2. While sperm count, motility, antioxidant parameters, testosterone hormone, germinal epithelial volume, and germinal epithelial height decreased in the diabetic group, abnormal sperm count, malondialdehyde level, and lumen volume increased. When Ferula rigidula (extract) was given to diabetic rats, it brought the stereological findings to the same level as the control group. In addition, it was determined that there were improvements in biochemical parameters, approaching the values of the control group. Specifically, when Ferula rigidula extract was administered alone, testosterone levels and stereological findings improved in group 1. In addition, it was determined that there were significant improvements in sperm parameters. However, it was determined that the positive effect of Ferula rigidula extract was very significant at low doses (250 mg/kg) and decreased at high doses (500 mg/kg). As a result, Ferula rigidula extract has an antioxidant role and can be used to alleviate the problems caused by diabetes in the male reproductive system.
Forame Oval Patente: A Contribuição do Doppler Transcraniano em seu Diagnóstico
Authors: Gripp Eliza de Almeida , Portela Ana Carolina de Freitas , Costa Flávio Luis da , Rabishoffsky Rafael , Medeiros Jéssica Rizkalla Corrêa , Rabischoffsky Arnaldo
Published: July 2023

O forame oval patente (FOP) é o tipo de shunt interatrial mais comum, com prevalência entre 25 e 27% da população adulta. Tem funcionamento flap-like e geralmente é assintomático. Em alguns casos, pode estar associado a complicações clínicas como acidente vascular encefálico (AVE), embolia paradoxal, síndrome de platipneia-ortodeóxia e apneia do sono obstrutiva. O diagnóstico se impõe principalmente em pacientes jovens que apresentam AVE, sem outro fator de risco aparente.
A avaliação do FOP é comumente realizada com ecocardiograma transtorácico (ETT) e o ecocardiograma transesofágico (ETE). Entretanto, outro importante método de avaliação pouco utilizado em nosso meio é o Doppler transcraniano (DTC), que avalia a presença de shunt de forma indireta em paciente acordado e com alta sensibilidade.
Desigualdades educacionais:
Authors: Freitas Gabriel Rocha , Santos Deivid Alex dos
Published: July 2023

O presente artigo teve por objetivo discutir acerca da desigualdade educacional como um fenômeno histórico e social, sob a ótica do fracasso escolar, tendo como objeto de estudo a análise da condição/situação de estudantes da escola pública, especialmente de estudantes negros(as). Para isso, analisou-se a desigualdade como um fenômeno histórico e social e discorreu-se acerca da produção do fracasso escolar de estudantes negros em meio ao sistema educacional brasileiro para, então, correlacioná-lo aos princípios dos discursos de igualdade e equidade. As discussões demonstraram que o racismo estrutural, como fenômeno histórico e social, ainda assola a escola, em especial, para a produção e a reprodução do fracasso escolar dos estudantes negros, condição evidenciada pelos índices escancarados de reprovação, evasão e permanência na escola. Ações afirmativas, que garantam a representatividade desse grupo nos diversos espaços, são necessárias, a fim de serem conquistados novos espaços democráticos.
PENGARUH PREEKLAMPSIA TERHADAP KEJADIAN PERSALINAN PRETERM DI RSKDIA PERTIWI MAKASSAR TAHUN 2023
Authors: Rika
Published: July 2023

Penelitian ini bertujuan untuk mengetahui apakah Preeklampsia mempengaruhi kejadian Persalinan Preterm di Rumah Sakit Ibu dan Anak Pertiwi Makassar tahun 2023.

Metode yang digunakan adalah penelitian medical record dengan pendekatan observasional case control.

Populasi penelitian ini adalah semua ibu yang bersalin di rumah sakit ibu dan anak pertiwi makassar sebanyak 426 orang. Dan Sampel sebanyak 300 dengan mengunakan tekhnik di rumah sakit ibu dan anak pertiwi makassar 2022 dengan sampel dalam penelitian ini secara Purposive Sampling.Analisis data dengan menggunakan uji chi squer

Hasil pengaruh preeklampsia (=0,5). Hal tersebut menunjukkan tidak ada hubungan antara preeklampsia dengan kejadian Persalinan Preterm. hasil penelitian yang dilakukan dapat ditarik kesimpulan bahwa Preeklampsia tidak ada pengaruh terhadap kejadian persalinan Preterm.Dari hasil penelitian ini disarankan Bagi para ibu yang berusia <20 tahun dan >35 tahun, paritas tinggi, dan ada riwayat penyakit lainya agar lebih memperhatikan kehamilannya untuk mencegah terjadinya hal-hal yang dapat berisiko dalam kehamilan dan persalinan.
Metabolic Effects of Electromagnetiс EHF Radiation and Ozone Therapy in the Engraftment of the Skin Flap
Authors: Martusevich Andrew K. , Sazonova Irina E. , Soloveva Anna G. , Fedotova Alexandra S. , Kovaleva Lida K.
Published: July 2023

The aim of this study was to evaluate the effect of ROS on the intensity of oxidative and energy metabolism in the blood of rats with an operational model of ischemia of the dorsal skin flap in vivo. Our studies have allowed us to establish that the modeling of an extensive skin defect is accompanied by pronounced shifts in oxidative metabolism in the blood plasma of animals. At the same time, in the absence of pathogenetic treatment, signs of oxidative stress are formed, including the intensification of free radical processes and the inhibition of general antioxidant activity in combination with the accumulation of an increased amount of lipoperoxidation products (in particular, malondialdehyde). Conducting experimental therapy with the introduction of ozone or treatment with electromagnetic radiation of the EHF band allows partially compensating for these metabolic disorders, however, the most optimal option is a combination of these factors within a single scheme. It should be noted that the results obtained are of great applied importance for the creation of innovative technologies for the complex medical rehabilitation of orthopedic-traumatological patients as a tool for influencing reparative processes in the lesion to restore and maintain tissue structures.
Digital Implementation of Neural Network by Partial Reconfiguration
Authors: Kumar C. Udhaya , Saravanan P. , Thiyagarajan N. , Raj Veena
Published: July 2023

Artificial Neural Networks (ANNs) are becoming increasingly important in the present technological era due to their ability to solve complex problems, adapt to new inputs, and improve decision-skills for different domains. The human brain serves as a model for Artificial Neural Networks (ANNs), a type of machine learning, as a reference for both structure and function. The existing work on ANNs supports tasks, such as regression, classification and pattern recognition separately. The discussion aims at resolving the above highlighted issues related to various ANN architectural implementations, considering the dynamic function exchange feature of FPGAs. With the aid of Zynq SOC, CNN and DNN architectures are designed in its Processing System, and the structure is accelerated using Programmable Logic. It also solves the issues due to trojans on design files, by introducing cryptography within the accelerator.
Inclusion and Higher Education Curriculum in the Post-COVID-19 Era and Implications for Technology-Based Learning
Authors: Onyishi Charity N. , Sefotho Maximus M.
Published: July 2023

The way curriculum is implemented is increasingly changing, making way for new and unfamiliar approaches to teaching and learning. This chapter discusses measures that ought to be put in place to help all students to access learning, participate meaningfully in learning activities, and progress in their studies in the post-COVID-19 era, as well as the implications of using technologies for learning. Based on the study findings, the authors make recommendations for further research and draw some conclusions.
Design Optimization Methods for Forced Lubrication System Used in
Automotive Transmissions
Authors: Shamini R. , Jadhav Priyanka , Deshpande Shrikrishna , Chavan Sagar
Published: July 2023

Lubrication has been a major area of interest in engineering. Especially in
vehicle transmissions, lubrication plays a very crucial role because gears and
bearings are constantly subjected to heavy loads. Proper lubrication is
essential for maintaining system performance and ensuring endurance life.
Insufficient lubrication can lead to excessive wear, increased friction, and
eventually, failures in the transmission components. However, excess lubrication
can result in power losses due to the resistance offered by the excessive
lubricant. Therefore, achieving effective lubrication using optimized
lubrication system design is vital for ensuring the longevity and efficiency of
the transmission system.

Majorly, two types of lubrication methods are used in transmissions: splash
lubrication and forced lubrication. This article focuses on forced lubrication,
where the lubrication system actively delivers the required flow of lubricant to
specific locations within the transmission. Pump outflow, orifice diameters, and
channel dimensions are a few of the critical design parameters of the forced
lubrication system. This article presents two design optimization methods: one
using ANSYS DX (3D) and the other using GT-Suite (1D) tool. In the 3D method,
ANSYS Fluent is used for CFD (computational fluid dynamics) simulations and
subsequently ANSYS DesignXplorer (DX) is leveraged for design optimization.
Predictions from CFD simulations are validated against physical test data and
show good agreement (>90% match for flow rate). GT-SUITE is used in the 1D
method, which is validated with predictions from 3D CFD method. The optimized
designs obtained from both methods are effective in achieving the desired flow
rate distribution, demonstrating their reliability. The ANSYS DX method provides
an advantage in terms of reduced overall turnaround time (50% less) for the
optimization. On the other hand, co-simulation (CFD+1D) approach can prove
beneficial if it is required to perform minor routing changes on the lube system
layout.
Controlling Aircraft—From Humans to Autonomous Systems: The Fading
Humans
Authors: David Aharon
Published: July 2023

While being the first to fly, the Wright Brothers were also the first and last
complete “one stop shop” of aviation: the only case in human flight in which the
same individuals personally carried out the research, development, testing,
manufacturing, operation, maintenance, air control, flight simulation, training,
setup, operation, and more. Since then, these facets gradually fragmented and
drifted away from the aircraft. This report discusses the phenomenon of aircraft
operation’s “fading humans,” including the development of flight instruments to
support it, its growing automation, the emerging artificial intelligence
paradigm, and the lurking cyber threats that all over the place.

Controlling Aircraft – From Humans to Autonomous Systems: The Fading
Humans examines the “fading” process itself, including its safety
aspects, current mitigation efforts, ongoing research, and the unsettled topics
that still remain.

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Bafa-Handreichung zum Lieferkettengesetz
Authors: Bender Hanno
Published: July 2023

Das Bundesamt für Wirtschaft und Ausfuhrkontrolle (Bafa) hat einen Leitfaden für Unternehmen veröffentlicht, die vom Lieferkettengesetz nur indirekt betroffen sind.
Verdis Warnstreiks landen vor Gericht
Authors: Falker Gerrit-Milena
Published: July 2023

In den laufenden Tarifverhandlungen im Einzelhandel tut sich ein Nebenkriegsschauplatz auf. Im Raum stehen Schadenersatzforderungen des Handels für eine vermeintlich rechtswidrige Streikforderung von Verdi.
Opinion: how are advances in aerosol science informing our understanding of the health impacts of outdoor particulate pollution?
Authors: El Haddad Imad , Daellenbach Kaspar , Modini Robin , Slowik Jay , Upadhyay Abhishek , Bell David , Vienneau Danielle , De Hoogh Kees , Prevot Andre S. H.
Published: July 2023

Abstract. Air pollution poses the greatest environmental threat to human health, causing an estimated nine million premature deaths annually and accounting for 5 % of the global GDP. This opinion paper explores how advances in aerosol science inform our understanding of the health impacts of outdoor particulate pollution. In the article, we advocate for a shift from solely considering total particulate matter (PM) mass to utilizing specific PM components as metrics for health assessments. This will allow targeted evidence-based interventions, limiting the most harmful anthropogenic emissions, while exempting uncontrollable or non-detrimental components. Central to this shift is the availability of global long-term PM chemical composition data obtained through field observations and modelling outputs. These data will serve as the new foundation for identifying the most harmful chemical components in different regions. We discuss emerging modelling tools for personalized exposure estimation to these components, present the type of ambient observations needed for model evaluation and highlight key gaps in our fundamental understanding of emissions and their health effects. Through global PM chemical composition data, advancements in modelling tools, and collaboration between aerosol scientists and epidemiologists, we can gain a deeper understanding of how different PM components influence disease development. The reevaluation of air quality guidelines with a focus on specific PM components will be essential for fostering healthier environments, preventing diseases and building resilient communities.
EXAMINING THE EFFECTIVENESS OF UNION COUNCILS IN SAFEGUARDING FAMILY RELATIONSHIPS: A CASE STUDY OF PAKISTAN
Authors: Azeem Baloch Zafar Ghouri, Shaikh Muhammad Farooq,
Published: July 2023

Family relationships are the foundation of society. They provide us with love, support, and a sense of belonging. However, family relationships can also be fragile. They can be strained by conflict, abuse, and neglect. In Pakistan, where traditional family values are strong, there is a growing concern about the breakdown of family relationships. Union councils (UCs) are local government bodies that have been given a mandate to safeguard family relationships. They are responsible for resolving family disputes, providing mediation services, and promoting awareness of family laws. However, there is little research on the effectiveness of UCs in fulfilling this mandate. In Pakistan, the institution of family holds immense cultural and social significance
Los derechos de la naturaleza en la jurisprudencia de la Corte Constitucional Ecuatoriana. Reconocimiento y evolución histórica
Authors: Martínez-Moscoso Andrés , Alarcón-Peña Pablo , Sánchez Espinosa Martina
Published: July 2023

Desde 2008, el Ecuador reconoció constitucionalmente a la naturaleza como sujeto de derechos, sin embargo, en un Estado constitucional de derechos y justicia como el ecuatoriano, la Corte Constitucional ha jugado un rol preponderante en el desarrollo de su contenido. El artículo estudia la evolución histórica de la jurisprudencia constitucional en esta materia. La investigación realizó un estudio crítico de las principales sentencias, para lo cual usó tres variables: patrimonio forestal, cuerpos hídricos y vida silvestre. En el trabajo se presentan los principales resultados, con énfasis en los casos del bosque protector Los Cedros, debido a la utilización del principio de prevención para el reconocimiento de los derechos de la naturaleza, y el caso "Estrellita", en el que se discutió sobre el reconocimiento de los animales silvestres como sujetos de derechos. El artículo concluye que, pese al avance en el desarrollo del contenido de estos derechos, es necesario que la academia, los gremios profesionales y abogados en libre ejercicio comprendan a cabalidad el contenido integral de este, y no intenten beneficiarse de párrafos aislados de las sentencias, lo que genera incertidumbres e interpretaciones erróneas, so pretexto de la protección de los derechos de la naturaleza.
Novel Renewable Energy Source in Standalone Microgrid Application with Island Load Management
Authors:   University of Çankırı Karatekin, Teke Mustafa , Yatak Meral Ö. ,   University of Gazi, Yaseen Ethar S. ,   University of Çankırı Karatekin
Published: July 2023

Renewable energy sources, which use natural sources to generate energy, are currently replacing conventional energy sources to fulfil the world’s expanding energy demands. However, photovoltaic and wind energy, which are among these types of energy sources, are not steady and not available for 24 hours in a day. As an alternative, it is possible to extract and use hot water from the earth all the time. Therefore, this study proposes a thermoelectric generator that uses hot water from the hot spring area to generate free electricity as a new renewable energy source in a microgrid application. In this system, the microgrid is standalone without a battery storage system because the thermoelectric generator is in operation for 24 hours in a day (day and night). In this way, the cost of the battery is eliminated by removing it from the system. In this paper, a novel generation method is proposed in microgrid applications as a renewable energy source. In addition, load management system was implemented to control three types of residence loads. The main advantage of this study is to generate electricity from renewable sources like photovoltaic and thermoelectric to demand without much wasting energy by controlled loads according to the proposed load management algorithm. In this study, the microgrid and energy management control is modeled with MATLAB/Simulink. The results showed that the essential load is always active through thermos electric generator besides the absence of battery storage system.
Rezension von: Planert, Ute, Der Mythos vom Befreiungskrieg
Authors: Wettengel Michael , Planert Ute
Published: July 2023

Ute Planert: Der Mythos vom Befreiungskrieg. Frankreichs Kriege und der deutsche Süden: Alltag - Wahrnehmung - Deutung 1792-1841 (Krieg in der Geschichte 33). Paderborn: Ferdinand Schöningh Verlag 2007; 739 S., eine Faltkarte, geb., 68,- EUR
Globalization and economic consequences of multilingualism
Authors: Vasilachi Serghei
Published: July 2023

Languages can build bridges between people, giving them access to other countries and cultures and enabling them to understand each other better. Knowledge of foreign languages plays a vital role in increasing employability and mobility. Multilingualism also improves the competitiveness of the EU economy. Due to the lack of language skills, companies lose international contracts and the mobility of skills and talents is hampered. In order to develop the skills required in the labor market, the European Commission cooperates with stakeholders in education and entrepreneurship.
Ad-hoc evaluation of judges: panacea or Procust’s bed?
Authors: Ciugureanu-Mihailuţă Carolina
Published: July 2023

This study is reserved for the analysis of the problem of "special" evaluation of the Moldovan judicial system. The article reflects the purpose, necessity, justification, guarantees, international standards, but also the risks of ad hoc evaluation of judges. Any evaluation procedure of judges must pursue the sole purpose of enhancing the performances of judges. Ad hoc evaluation of judges may be necessary and justified if it is demonstrated that the judicial system is compromised to such an extreme degree and depth that the application of ordinary measures to ensure the evaluation and accountability of judges is not feasible to guarantee judicial independence, impartiality and integrity. In such a case, it is necessary to provide for a number of strict safeguards in order to provide protection to judges who conscientiously fulfill their duties. The application of measures to purify the judiciary without taking into account the international standards of fair trial or the basic principles of the independence of judges will compromise the intended objective, that of strengthening the judiciary, and will, on the contrary, undermine it.
Interim measures in the english civil proceedings
Authors: Bâcu Adelina
Published: July 2023

The process of reforming the justice system is a difficult and complex one, and sometimes we face situations when institutions that, despite undergoing extensive legislative transformations, nevertheless, show gaps and imperfections in judicial practice. Among these institutions is the mechanism for ensuring civil action. Thus, currently the litigants from the Republic of Moldova are frequently confronted, either with the lack of complete tools that would ensure their interests, or with the negligence or abuse of the courts in terms of ensuring civil action. At the same time, internationally, there are states that stand out for the undeniable success of the legal instruments requested by the applicant and applied by the court, which protect the interested party from possible tricks of the defendant to create difficulties in the future execution of decision. Among such states, the United Kingdom stands out, which, through the ways of ensuring the action taken, offers a panacea against the abuses of the subjects involved in obligatory relations, but also increases the credibility of the justice system in the view of the litigant. However, such models can also provide positive examples for our legal system.
With AESM happy to the depths of old age
Authors: Todoroi Dumitru
Published: July 2023

Old age is a particular life stage for older people and an appropriate approach by society to this phenomenon is very necessary.
Bibliography database metadata – challenges and solutions
Authors: Cojocaru Irina
Published: July 2023

Any function of bibliographic databases cannot be performed without metadata. Creating and managing metadata is a key activity and a commune responsibility of content producers, distributors and users, as important as the content itself. Open and relevant metadata contribute to increasing the visibility of digital scientific content.
The virtual learning environment for professional library staff. Case study
Authors: Povestca Lilia
Published: July 2023

The article presents the results of the study on the degree of satisfaction of the professional development program in online format; the role of online training; identification of training methods in the virtual environment; determining preferences; staff opinions; assessment of digital skills needed to participate in online tools, etc.
Assessment of user information needs in the scientific library of the Academy of Economic Studies from Moldova
Authors: Amorţitu Angela , Railean Elena
Published: July 2023

The paper highlights the results of a study of the information needs of users of the ASEM Scientific Library. The results of the survey demonstrated the high status of the Scientific Library and made it possible to propose new strategies for the development of the library.
The satisfaction degree of doctoral students with the services provided by the ASEM scientific library
Authors: Nicuță Ina , Cheradi Natalia
Published: July 2023

The article presents the results of the research of the degree of satisfaction of doctoral students regarding the services of the Scientific Library of Academy of Economic Studies of Moldova, the conclusions and recommendations for improving the informational service of doctoral students.
Obstetrik Şiddet Ve Ebe/Hemşirelerin Sorumlulukları
Authors: IŞIK Bedia , NAZİK Evşen
Published: July 2023

Gebelik, doğum ve doğum sonrası dönemde kadına verilen her türlü zarar olarak tanımlanan ve küresel bir halk sağlığı sorunu olarak ele alınan obstetrik şiddet, bir insan hakkı ihlalidir. Obstetrik şiddet; sözel ve fiziksel şiddeti, özerkliğin reddi, gereksiz tıbbi prosedürlerin uygulanmasını, ırk veya etnik kökene dayalı ayrımcılığı içerir. Literatürde obstetrik şiddetin görülme sıklığının ülkeden ülkeye değişiklik gösterdiği, nedeninin tam olarak bilinmediği ve maternal/fetal sağlığı olumsuz etkilediği bilinmektedir. Obstetrik şiddetin önlenmesinde hemşire ve ebelere önemli sorumluluklar düşmektedir. Bu derlemede obstetrik şiddetin tanımı, görülme sıklığı, türleri, risk faktörleri, maternal/fetal sonuçları ve hemşire/ebelerin sorumluluklarından bahsedilmiştir.
A Systematic Review of Research Developments in Mass Psychogenic Illness
Authors: Yan Wentao
Published: July 2023

This study explores the development of research on mass psychogenic illness (MPI) over recent decades. The literature review was used as the research methodology for this study, and dozens of published case reports and studies are reviewed in this paper. First, the paper reviews past researchers' general recognition of mass psychogenic illness. The paper includes the two subtypes of mass psychogenic disorders, 'mass anxiety hysteria' and 'mass motor hysteria', as well as the characteristics and common symptoms of the outbreak of mass psychogenic illness and the suspicion of the existence of mass psychogenic illness by some scholars. Secondly, historical cases of mass psychogenic illness outbreaks are reviewed in chronological order, from the Middle Ages through to the 21st century. Thirdly, new trends in the development of mass psychogenic illness and a new type of mass psychogenic illness, MSMI, proposed by researchers are reviewed. Finally, two important studies from the past decade are reviewed. The findings of two studies, the inducibility of mass psychogenic illness and hypnotizability, an important predictor to the emergence of cases of mass psychogenic illness, are also presented. Besides, some implications for future research into mass psychogenic illness are given through the review.