bluuebunny/crossref_metadata_2025 huggingface dataset:
Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry
Authors: Andrieu Thomas , du Toit Therina , Vogt Bruno , Mueller Michael D. , Groessl Michael
Published: January 2022

We developed and validated a liquid chromatography high-resolution mass spectrometry method for the absolute quantification of 51 steroids for clinical analysis of human serum and, for the first time, peritoneal fluid. Data acquisition was performed in both targeted and untargeted mode simultaneously, thus allowing the accurate and precise quantification of the main components of the classical steroid pathways (17 steroids) as well as the analysis of 34 additional non-classical steroids. For targeted analysis, validation was performed according to FDA guidelines, resulting, among other parameters, in accuracy < 13% RSD and precision < 10% relative error, for both inter- and intra-day validation runs. By establishing steroid-specific response factors, the calibration curves of the targeted analytes can be extended to untargeted analytes. This approach opens novel possibilities for the post hoc analysis of clinical samples as the data can be examined for virtually any steroid even after data acquisition, enabling facile absolute quantification once a standard becomes available. We demonstrate the applicability of the approach to evaluate the differences in steroid content between peripheral serum and peritoneal fluid across the menstrual cycle phases, as well as the effect of the synthetic gestagen dienogest on the steroid metabolome.

Graphical abstract
Unfolding the mechanical properties of buckypaper composites: nano- to macro-scale coupled atomistic-continuum simulations
Authors: Chandra Y. , Adhikari S. , Mukherjee S. , Mukhopadhyay T.
Published: January 2022

Carbon-based nanostructures are receiving increasing attention over the past two decades due to their unprecedented multi-functional features. However, the macro-scale structural applications of these nanostructures have not yet come to full fruition due to the involvement of complex multi-scale computations and manufacturing. Recently, the research community has started investigating buckypaper, which can be described as a sheet or membrane developed using a network of bundles of single-wall carbon nanotubes, multi-wall carbon nanotubes, or a mixture of both. This article aims to focus on the computational bridging of different length scales involving six levels in the range of nano- to macro-scale behaviour concerning buckypaper composites. The sequential derivatives of carbon at six levels, as analyzed in this paper, involve graphene, CNT, CNT bundle, buckypaper, and buckypaper composite automotive components. Here, we adopt a coupled atomistic-continuum modelling approach for the multi-level simulations. Graphene, CNTs, and CNT bundles are modelled using atomistic simulations, while the buckypaper and its composites are modelled using equivalent beam representations for the bundles and continuum solid representation for resin. At the macro-scale, an industry-relevant multi-material composite automotive component has been investigated, wherein the buckypaper is proposed to be embedded involving sheet moulding compound and carbon prepreg. The current simulations have led to the determination of mechanical properties at each level of the carbon-based materials and their mutual dependence. The numerical results demonstrate that a buckypaper composite can enhance the natural frequency and stiffness up to 25 and 37$$\%$$%with respect to conventional monolithic metallic designs, while reducing the weight by 57$$\%$$%. Such outcomes lead to the realization that carbon-based nanostructural derivative in the form of buckypaper can significantly improve the mechanical properties of advanced lightweight structural components as reinforcements for the next generation of aerospace and automotive structures.

Graphical abstract
Effect of cochlear implantation on cognitive decline and quality of life in younger and older adults with severe-to-profound hearing loss
Authors: Calvino Miryam , Sánchez-Cuadrado Isabel , Gavilán Javier , Gutiérrez-Revilla M. Auxiliadora , Polo Rubén , Lassaletta Luis
Published: January 2022

Purpose

(a) To measure the change in cognition, the improvement of speech perception, and the subjective benefit in people under and over 60 years following cochlear implantation. (b) To assess the relationship between cognition, demographic, audiometric, and subjective outcomes in both age groups.

Methods

28 cochlear implant (CI) users were assigned to the < 60y group and 35 to the ≥ 60y group. Cognition was measured using the Repeatable Battery for the Assessment of Neuropsychological Status for Hearing impaired individuals (RBANS-H); subjective benefit was measured using the Nijmegen Cochlear Implant Questionnaire (NCIQ); the Glasgow Benefit Inventory (GBI); the Hearing Implant Sound Quality Index (HISQUI19); Speech, Spatial and Qualities of Hearing Scale (SSQ12); and the Hospital Anxiety and Depression Scale (HADS).

Results

Prior to surgery: the RBANS-H total score positively correlated with the domains “Advanced sound”, “Self-esteem”, and “Social functioning” of NCIQ, and negatively with HADS scores. 12 months post-implantation: the RBANS-H total score increased in the < 60y (p = 0.038) and in the ≥ 60y group (p < 0.001); speech perception and subjective outcomes also improved; RBANS-H total score positively correlated with “Self-esteem” domain in NCIQ. Age and the RBANS-H total score correlated negatively in the ≥ 60y group (p = 0.026).

Conclusions

After implantation, both age groups demonstrated improved cognition, speech perception and quality of life. Their depression scores decreased. Age was inversely associated with cognition.
Clinical characteristics and outcome of patients with acute mesenteric ischemia: a retrospective cohort analysis
Authors: Martini Verena , Lederer Ann-Kathrin , Fink Jodok , Chikhladze Sophia , Utzolino Stefan , Fichtner-Feigl Stefan , Kousoulas Lampros
Published: January 2022

Background

Acute mesenteric ischemia (AMI) is an uncommon, but life-threatening clinical entity due to late diagnosis resulting in irreversible ischemic bowel necrosis. The most common causes of AMI are the embolic occlusion and the acute thrombosis of the mesenteric circulation. Typical treatment is composed of an early revascularization of the mesenteric circulation followed by abdominal surgery for resection of nonviable intestine and restoration of the intestinal continuity, but the mortality rates remain high.

Methods

A retrospective cohort analysis was conducted, aiming to evaluate clinical characteristics, performed surgical procedures and outcomes of patients with acute mesenteric ischemia who underwent emergency abdominal surgery at a high volume surgical center in Germany.

Results

Overall, 53 patients were identified with the intraoperatively proven diagnosis of AMI. Overall hospital mortality was with 62% comparable to the literature. Nineteen patients presented with an intraoperatively verified complete and non-reversible intestinal infarction without any angiographic or surgical option for a revascularization of the mesenteric circulation or an option for intestinal resection. From the rest of the patients, 14 underwent intestinal resection of the ischemic area without restoration of intestinal continuity; the other 20 underwent resection with a primary anastomosis to restore intestinal continuity. The mortality rate of these patients with curative-intended surgery remained high (41% of patients died). Pre- and postoperative hyperlactatemia were associated with lower survival of these patients.

Conclusion

AMI remains a life-threatening abdominal emergency. Therapeutic approaches are highly depended on acting surgeon’s decision, being affected by subjectively rated bowel viability and physical condition of the affected patient. Only selected patients with good bowel viability appear to be suitable for receiving primary anastomosis. The results clearly indicate the need for further research to develop therapeutic approaches for a better management of AMI and to improve outcome of affected patients.
Data portability for activities of daily living and fall detection in different environments using radar micro-doppler
Authors: Shah Syed Aziz , Tahir Ahsen , Le Kernec Julien , Zoha Ahmed , Fioranelli Francesco
Published: January 2022

The health status of an older or vulnerable person can be determined by looking into the additive effects of aging as well as any associated diseases. This status can lead the person to a situation of ‘unstable incapacity’ for normal aging and is determined by the decrease in response to the environment and to specific pathologies with apparent decrease of independence in activities of daily living (ADL). In this paper, we use micro-Doppler images obtained using a frequency-modulated continuous wave radar (FMCW) operating at 5.8 GHz with 400 MHz bandwidth as the sensor to perform assessment of this health status. The core idea is to develop a generalized system where the data obtained for ADL can be portable across different environments and groups of subjects, and critical events such as falls in mature individuals can be detected. In this context, we have conducted comprehensive experimental campaigns at nine different locations including four laboratory environments and five elderly care homes. A total of 99 subjects participated in the experiments where 1453 micro-Doppler signatures were recorded for six activities. Different machine learning, deep learning algorithms and transfer learning technique were used to classify the ADL. The support vector machine (SVM), K-nearest neighbor (KNN) and convolutional neural network (CNN) provided adequate classification accuracies for particular scenarios; however, the autoencoder neural network outperformed the mentioned classifiers by providing classification accuracy of ~ 88%. The proposed system for fall detection in elderly people can be deployed in care centers and is application for any indoor settings with various age group of people. For future work, we would focus on monitoring multiple older adults, concurrently in indoor settings using continuous radar sensor data stream which is limitation of the present system.
Short-term outcomes of minimally invasive retromuscular ventral hernia repair using an enhanced view totally extraperitoneal (eTEP) approach: systematic review and meta-analysis
Authors: Aliseda D. , Sanchez-Justicia C. , Zozaya G. , Lujan J. , Almeida A. , Blanco N. , Martí-Cruchaga P. , Rotellar F.
Published: January 2022

Background

The enhanced view totally extraperitoneal (eTEP) approach is becoming increasingly more widely accepted as a promising technique in the treatment of ventral hernia. However, evidence is still lacking regarding the perioperative, postoperative and long-term outcomes of this technique. The aim of this meta-analysis is to summarize the current available evidence regarding the perioperative and short-term outcomes of ventral hernia repair using eTEP.

Study design

A systematic search was performed of PubMed, EMBASE, Cochrane Library and Web of Science electronic databases to identify studies on the laparoscopic or robotic-enhanced view totally extraperitoneal (eTEP) approach for the treatment of ventral hernia. A pooled meta-analysis was performed. The primary end point was focused on short-term outcomes regarding perioperative characteristics and postoperative parameters.

Results

A total of 13 studies were identified involving 918 patients. Minimally invasive eTEP resulted in a rate of surgical site infection of 0% [95% CI 0.0–1.0%], a rate of seroma of 5% [95% CI 2.0–8.0%] and a rate of major complications (Clavien–Dindo III–IV) of 1% [95% CI 0.0–3.0%]. The rate of intraoperative complications was 2% [95% CI 0.0–4.0%] with a conversion rate of 1.0% [95% CI 0.0–3.0%]. Mean hospital length of stay was 1.77 days [95% CI 1.21–2.24]. After a median follow-up of 6.6 months (1–24), the rate of recurrence was 1% [95% CI 0.0–1.0%].

Conclusion

Minimally invasive eTEP is a safe and effective approach for ventral hernia repair, with low reported intraoperative complications and good outcomes.
Bone mineral density, vitamin D receptor (VDR) gene polymorphisms, fracture risk assessment (FRAX), and trabecular bone score (TBS) in rheumatoid arthritis patients: connecting pieces of the puzzle
Authors: Senosi Manar R. , Fathi Hanan M. , Baki Noha M. Abdel , Zaki Othman , Magdy Ahmed M. , Gheita Tamer A.
Published: January 2022

Purpose

To assess vitamin D receptor (VDR) gene polymorphisms and bone mineral density and to investigate the possible risk factors of osteoporosis and fracture in rheumatoid arthritis (RA).

Methods

A total of 97 RA patients and 45 matched controls were enrolled. Serum vitamin D level, VDR genotyping, dual-energy X-ray absorptiometry (DEXA) scan, trabecular bone score (TBS), and fracture risk assessment (FRAX) in 10 years were assessed. Disease activity score (DAS28) and modified health assessment questionnaire (MHAQ) were measured.

Results

The mean age of the patients was 47.9 ± 8.9 years; 85 females, 12 males (F:M 7.1:1) and mean disease duration 9.4 ± 6.2 years. DAS28 was 4.52 ± 1.04 and MHAQ 0.6 ± 0.4. There was a significant difference between cases and controls as regards DEXA and FRAX (p < 0.0001) but the TBS and VDR genotyping were comparable (p = 0.29 and p = 0.12, respectively). The vitamin D level was comparable with the control (9.3 ± 6.5 vs 10.4 ± 7.5 ng/mL, p = 0.4). None of the patients was receiving anti-osteoporotic therapy or biologic therapy. There was a significant association between the presence of osteoporosis and age, disease duration, menopause, and rheumatoid factor (RF) positivity. The TBS was significantly lower and FRAX higher in patients with positive RF and anti-CCP. FRAX was significantly related and the TBS inversely with the age, disease duration, serum uric acid, alkaline phosphatase, and MHAQ.

Conclusions

Reduced BMD and increased tendency to fractures are remarkable in RA patients. Vitamin D level was decreased in patients and control, and VDR gene polymorphisms were not linked to RA. TBS and FRAX are effective tools to assess osteoporotic fractures in RA.

Key Points• Reduced bone mineral density (BMD) and increased tendency to fractures are remarkable in rheumatoid arthritis (RA) patients.• Vitamin D level was decreased in patients and control, and VDR gene polymorphisms were not linked to RA.• Trabecular bone score (TBS) and fracture risk assessment (FRAX) in 10 years are effective tools to assess osteoporotic fractures in RA.
A robust approach to warped Gaussian process-constrained optimization
Authors: Wiebe J. , Cecílio I. , Dunlop J. , Misener R.
Published: January 2022

Optimization problems with uncertain black-box constraints, modeled by warped Gaussian processes, have recently been considered in the Bayesian optimization setting. This work considers optimization problems with aggregated black-box constraints. Each aggregated black-box constraint sums several draws from the same black-box function with different decision variables as arguments in each individual black-box term. Such constraints are important in applications where, e.g., safety-critical measures are aggregated over multiple time periods. Our approach, which uses robust optimization, reformulates these uncertain constraints into deterministic constraints guaranteed to be satisfied with a specified probability, i.e., deterministic approximations to a chance constraint. While robust optimization typically considers parametric uncertainty, our approach considers uncertain functions modeled by warped Gaussian processes. We analyze convexity conditions and propose a custom global optimization strategy for non-convex cases. A case study derived from production planning and an industrially relevant example from oil well drilling show that the approach effectively mitigates uncertainty in the learned curves. For the drill scheduling example, we develop a custom strategy for globally optimizing integer decisions.
On the adoption of blockchain for business process monitoring
Authors: Di Ciccio Claudio , Meroni Giovanni , Plebani Pierluigi
Published: January 2022

Being the blockchain and distributed ledger technologies particularly suitable to create trusted environments where participants do not trust each other, business process management represents a proper setting in which these technologies can be adopted. In this direction, current research work primarily focuses on blockchain-oriented business process design, or on execution engines able to enact processes through smart contracts. Conversely, less attention has been paid to study if and how blockchains can be beneficial to business process monitoring. This work aims to fill this gap by (1) providing a reference architecture for enabling the adoption of blockchain technologies in business process monitoring solutions, (2) defining a set of relevant research challenges derived from this adoption, and (3) discussing the current approaches to address the aforementioned challenges.
Bundesverfassungsgericht und Klimaschutz – wenn die Zukunft über die Gegenwart mitentscheiden darf
Authors: Kotulla Katharina , Kotulla Michael
Published: January 2022

Das Bundesverfassungsgericht (BVerfG) hat in seiner weithin beachteten und für viele überraschenden
Entscheidung vom 24.3.2021 nicht nur dem Klimaschutz zu einem verfassungsrechtlich neuen Stellenwert verholfen,
sondern auch in den Grundrechten einen bisher nicht gekannten intertemporalen Charakter identifiziert. Der
nachfolgende Beitrag befasst sich kritisch mit der daraus resultierenden Bedeutung und den damit verbundenen
Folgen des Judikats.
The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis
Authors: Dold Manuel Nico , Ng Xiulin , Alber Claudia , Gentle Ian Edward , Häcker Georg , Weber Arnim
Published: January 2022

Death receptors are transmembrane proteins that can induce the activation of caspase-8 upon ligand binding, initiating apoptosis. Recent work has highlighted the great molecular complexity of death receptor signalling, in particular through ubiquitination/deubiquitination. We have earlier defined the deubiquitinase Ubiquitin-Specific Protease 27x (Usp27x) as an enzyme capable of stabilizing the pro-apoptotic Bcl-2 family member Bim. Here, we report that enhanced expression of Usp27x in human melanoma cells leads to the loss of cellular FLICE-like inhibitory protein (cFLIP) and sensitizes to Tumor necrosis factor receptor 1 (TNF-R1) or Toll-like receptor 3 (TLR3)-induced extrinsic apoptosis through enabling enhanced processing of caspase-8. The loss of cFLIPL upon overexpression of Usp27x was not due to reduced transcription, could be partially counteracted by blocking the ubiquitin proteasome system and was independent of the known cFLIPL destabilizing ubiquitin E3-ligases Itch and DTX1. Instead, Usp27x interacted with the E3-ligase TRIM28 and reduced ubiquitination of TRIM28. Reduction of cFLIPL protein levels by Usp27x-induction depended on TRIM28, which was also required for polyI:C-induced cell death. This work defines Usp27x as a novel regulator of cFLIPL protein expression and a deubiquitinase in fine tuning death receptor signalling pathways to execute apoptosis.
“Traduttore, Traditore?” Translating Human Rights into the Corporate Context
Authors: McVey Marisa , Ferguson John , Puyou François-Régis
Published: January 2022

This paper critically investigates the implementation of the UN guiding principles on business and human rights (UNGPs) into the corporate setting through the concept of ‘translation’. In the decade since the creation of the UNGPs, little academic research has focussed specifically on the corporate implementation of human rights. Drawing on qualitative case studies of two multinational corporations—an oil and gas company and a bank—this paper unpacks how human rights are translated into the corporate context. In doing so, the paper focuses on the “resonance dilemma” translators encounter, the strategies used to make human rights understandable and palatable, and the difficulties that emerge from this process. We contend that the process of making human rights understandable and manageable can change their form and content, which may act as an obstacle to human rights realisation and corporate accountability for human rights.
Factors Enhancing Trust in Electronic Communication Among Patients from an Internal Medicine Clinic: Qualitative Results of the RECEPT Study
Authors: Moore Annie , Chavez Catia , Fisher Michael P.
Published: January 2022

Background

Electronic health records are now the norm in US healthcare. Bidirectional patient portals allow frequent communication between patients and their healthcare team. Many studies have examined the importance of patient engagement and trust between patients and their healthcare team, typically in the context of face-to-face interactions. Little is known about how patient trust and engagement are built or enhanced through electronic communications. COVID-19 provided a unique time in history for this novel exploration.

Objective

Our objective was to learn how patients experience trust formation through electronic communication (patient messaging and video visits) with their healthcare team.

Design

Our research was guided by grounded theory methodology. Qualitative interviews were conducted between February and December 2020 with patients or their caregivers from an internal medicine clinic in Colorado.

Participants

Fifty-one participants were recruited by age group and gender to represent the clinic’s adult ambulatory care demographics. Seven were patients’ caregivers who were purposefully recruited. Average age was 53 with an educated, middle class, and largely white predominance in our eventual sample.

Approach

Thirty-minute semi-structured interviews were conducted using an interview guide informed by a validated physician-patient trust scale. Interviews were conducted by telephone, recorded via Zoom, and transcribed. Results were analyzed and coded in ATLAS.ti utilizing the constant comparative method, with two coders.

Key Results

Patients experienced enhanced trust in their healthcare team through electronic communications. Interpersonal and system factors contributed to trust formation. Promptness of reply was the most salient factor in trust formation with a majority desiring same day response.

Conclusions

Patients now rely on electronic communication with their healthcare team. Opportunities exist to leverage this to improve health outcomes. Important research in expanded demographic groups, along with ambulatory healthcare redesign, will be necessary to optimize benefits of electronic communication with patients and meet patient expectations.
Non-pharmacological Treatment for Chronic Pain in US Veterans Treated Within the Veterans Health Administration: Implications for Expansion in US Healthcare Systems
Authors: Mannes Zachary L. , Stohl Malki , Fink David S. , Olfson Mark , Keyes Katherine M. , Martins Silvia S. , Gradus Jaimie L. , Saxon Andrew J. , Maynard Charles , Livne Ofir , Gutkind Sarah , Hasin Deborah S.
Published: January 2022

Background

Consensus guidelines recommend multimodal chronic pain treatment with increased use of non-pharmacological treatment modalities (NPM), including as first-line therapies. However, with many barriers to NPM uptake in US healthcare systems, NPM use may vary across medical care settings. Military veterans are disproportionately affected by chronic pain. Many veterans receive treatment through the Veterans Health Administration (VHA), an integrated healthcare system in which specific policies promote NPM use.

Objective

To examine whether veterans with chronic pain who utilize VHA healthcare were more likely to use NPM than veterans who do not utilize VHA healthcare.

Design

Cross-sectional nationally representative study.

Participants

US military veterans (N= 2,836).

Main Measures

In the 2019 National Health Interview Survey, veterans were assessed for VHA treatment, chronic pain (i.e., past 3-month daily or almost daily pain), symptoms of depression and anxiety, substance use, and NPM (i.e., physical therapy, chiropractic/spinal manipulation, massage, psychotherapy, educational class/workshop, peer support groups, or yoga/tai chi).

Key Results

Chronic pain (45.2% vs. 26.8%) and NPM use (49.8% vs. 39.4%) were more prevalent among VHA patients than non-VHA veterans. After adjusting for sociodemographic characteristics, psychiatric symptoms, physical health indicators, and use of cigarettes or prescription opioids, VHA patients were more likely than non-VHA veterans to use any NPM (adjusted odds ratio [aOR] = 1.52, 95% CI: 1.07–2.16) and multimodal NPM (aOR = 1.80, 95% CI: 1.12–2.87) than no NPM. Among veterans with chronic pain, VHA patients were more likely to use chiropractic care (aOR = 1.90, 95% CI = 1.12–3.22), educational class/workshop (aOR = 3.02, 95% CI = 1.35–6.73), or psychotherapy (aOR = 4.28, 95% CI = 1.69–10.87).

Conclusions

Among veterans with chronic pain, past-year VHA use was associated with greater likelihood of receiving NPM. These findings may suggest that the VHA is an important resource and possible facilitator of NPM. VHA policies may offer guidance for expanding use of NPM in other integrated US healthcare systems.
Comparison of quick Pitt to quick sofa and sofa scores for scoring of severity for patients with urinary tract infection
Authors: Madrazo Manuel , Piles Laura , López-Cruz Ian , Alberola Juan , Eiros José María , Zaragoza Rafael , Artero Arturo
Published: January 2022

Quick Pitt (qPitt), which includes temperature, systolic blood pressure, respiratory rate, cardiac arrest, and mental status, is a new prognostic score derived from the Pitt Bacteremia score. The aim of our study is to compare qPitt with quick SOFA (qSOFA) and SOFA for scoring of severity in patients with urinary tract infection (UTI). Prospective observational study of patients diagnosed with UTI. Area under the ROC curve, sensibility, and specificity to predict 30-day mortality were calculated for qPitt, qSOFA and SOFA and compared. 382 UTI cases were analyzed. Thirty-day mortality (18.8% vs. 5.9%, p < 0.001) and longer hospital stay (6 [1–11] vs. 4 [1–7] days, p < 0.001) were associated with qPitt ≥ 2. However, qPitt had a worse performance to predict 30-day mortality compared to qSOFA and SOFA (AUROC 0.692 vs. 0.832 and 0.806, respectively, p = 0.010 and p = 0.041). The sensitivity of qPitt was lower than the sensitivity of qSOFA and SOFA (70.45 vs. 84.09 for both qSOFA and SOFA, p < 0.001), with a specificity lower than qSOFA and similar to SOFA (60.36 vs. 82.25 and 63.61, p < 0.001 and p = 0.742, respectively). Quick Pitt had moderate prognostic accuracy and performed worse than qSOFA and SOFA scores for predicting mortality in patients with UTI.
Assessment of the mineral phase and properties of clay-Ca bentonite lightweight aggregates
Authors: Abdelfattah Mohamed Mostafa , Géber Róbert , Abdel-Kader Noha Ali , Kocserha István
Published: January 2022

This study deals with improving the properties of lightweight aggregate by the addition of Ca-bentonite mineral to expandable clays. The addition of bentonite can result in advanced lightweight aggregate materials which meet international standards. Besides bentonite material, twelve different clays (from Egyptian and Hungarian mines) were studied by X-ray fluorescence (XRF), X-ray powder diffraction (XRD, Rietveld method), and a heating microscope (HM). Aggregates were produced and their physical and mechanical properties were measured. The structure and the chemical composition of the clay-Ca bentonite aggregates were studied by scanning electron microscope (SEM) and with energy dispersive spectroscopy (EDAX). The results showed that the addition of 10 wt% bentonite can reduce the bulk density by up to 20%, can increase the compressive strength by up to 180%, and can increase the height of expansion by up to 68% in some samples. It was found that the high kaolinite content of the clay samples was not beneficial for expanding and decreasing the bulk density of aggregates. According to the Rietveld method from XRD and a statistical correlation model shown, the amorphous contents have a reciprocal relationship with the bulk density and a direct relationship with the height expansion. Bentonite, as a natural additive, to some clays, was suitable for producing lightweight aggregates with far better properties, as well as a more economical means of production.
Zur Notwendigkeit und Chance einer sozial(räumlich)en Perspektive und einer Einmischung Sozialer Arbeit im interdisziplinären Diskurs zum Wohnen
Authors: Beck Sylvia
Published: January 2022

Das Thema Wohnen wird derzeit angesichts von Wohnungsmarktdynamiken vielfach diskutiert, bleibt dabei jedoch weitgehend auf Fragen einer bezahlbaren Wohnraumversorgung fokussiert. Exemplarisch aufgezeigte aktuelle Entwicklungen verweisen jedoch zugleich auf gesellschaftliche und individuelle Anforderungen ans Wohnen, die Transformationsprozesse mitbedingen. Darin werden auch Selbstzuständigkeiten wie auch deren Vereinnahmung sichtbar, die hinsichtlich neuerlicher Ausschlüsse kritisch zu hinterfragen sind. Gestützt auf das Konzept von „Wohnen als sozial(räumlich)e Praxis“ plädiert der Beitrag für eine sozialräumliche und lebensweltorientierte Sicht auf Wohnen im Kontext Sozialen Wandels. Er macht sich damit zugleich für eine Einmischung Sozialer Arbeit im interdisziplinären Diskurs zum Wohnen und in Wohn- und Stadtentwicklungen stark, um für ermöglichende, sozial gerechte Strukturen einzutreten, aber auch Aneignungsprozesse in ihrer Relevanz herauszustellen.
Perioperative Guidelines on Antiplatelet and Anticoagulant Agents: 2022 Update
Authors: Moster Michael , Bolliger Daniel
Published: January 2022

Purpose of Review

Multiple guidelines and recommendations have been written to address the perioperative management of antiplatelet and anticoagulant drugs. In this review, we evaluated the recent guidelines in non-cardiac, cardiac, and regional anesthesia. Furthermore, we focused on unresolved problems and novel approaches for optimized perioperative management.

Recent Findings

Vitamin K antagonists should be stopped 3 to 5 days before surgery. Preoperative laboratory testing is recommended. Bridging therapy does not decrease the perioperative thromboembolic risk and might increase perioperative bleeding risk. In patients on direct-acting oral anticoagulants (DOAC), a discontinuation interval of 24 and 48 h in those scheduled for surgery with low and high bleeding risk, respectively, has been shown to be saved. Several guidelines for regional anesthesia recommend a conservative interruption interval of 72 h for DOACs before neuraxial anesthesia. Finally, aspirin is commonly continued in the perioperative period, whereas potent P2Y12 receptor inhibitors should be stopped, drug-specifically, 3 to 7 days before surgery.

Many guidelines have been published from various societies. Their applicability is limited in emergent or urgent surgery, where novel approaches might be helpful. However, their evidence is commonly based on small series, case reports, or expert opinions.
Educator Attitudes Towards the Inclusion of Students with Autism Spectrum Disorders in Mainstream Education: a Systematic Review
Authors: Russell Amy , Scriney Aideen , Smyth Sinéad
Published: January 2022

Educator attitudes towards inclusive education impact its success. Attitudes differ depending on the SEN cohort, and so the current systematic review is the first to focus solely on students with autism spectrum disorders (ASD). Seven databases searched yielded 13 relevant articles. The majority reported positive educator attitudes towards ASD inclusion but with considerable variety in the measures used. There were mixed findings regarding the impact of training and experience on attitudes but, where measured, higher self-efficacy was related to positive attitudes. In summary, educator ASD inclusion attitudes are generally positive but we highlight the need to move towards more homogeneous attitudinal measures. Further research is needed to aggregate data on attitudes towards SEN cohorts other than those with ASD.
The global nuclear order and the crisis of the nuclear non-proliferation regime: Taking stock and moving forward
Authors: Baldus Jana , Müller Harald , Wunderlich Carmen
Published: January 2022

The Nuclear Non-Proliferation Treaty (NPT) is a central element of the global nuclear order, the primary goal of which is to prevent nuclear war. But this understanding is being threatened by a number of developments. Frustration about the lack of nuclear disarmament and concerns about humanitarian consequences of nuclear weapons led to the negotiation of the Treaty on the Prohibition of Nuclear Weapons (TPNW). The new treaty has further exposed existing fault lines within the NPT and exacerbated unresolved conflicts over the proper approach to disarmament and the weighting of the NPT pillars. Currently, disagreements over the compatibility of the two treaties and the approach to the TPNW in particular divide the membership of the NPT. At the same time, real proliferation cases test the regime’s ability to act, as norm enforcement is regularly hampered by interference from the great powers. These developments—the absence of genuine disarmament, disputes among NPT members, competition between the TPNW and the NPT, and actual nuclear proliferation—are part of a comprehensive crisis and destabilization of the non-proliferation regime. We argue that three developments are necessary to restabilize the regime: a cooperative resolution of the power struggles among the major powers; a depolarization of the inter-group divisions in the NPT; and a return to the principle of nuclear war prevention as a common maxim for action.
Photodynamic Inactivation of plant pathogens part II: fungi
Authors: Hamminger Christoph , Glueck Michael , Fefer Michael , Ckurshumova Wenzi , Liu Jun , Tenhaken Raimund , Plaetzer Kristjan
Published: January 2022

The constantly increasing demand for agricultural produce from organic and conventional farming calls for new, sustainable, and biocompatible solutions for crop protection. The overuse of fungicides leading to contamination of both produce and environment and the emergence of plant pathogenic fungi that are resistant to conventional treatments warrant the need for new methods to combat fungal infections in the field. We here deliver the follow-up study to our research on the Photodynamic Inactivation (PDI) of plant pathogenic bacteria (Glueck et al. in Photochem Photobiol Sci 18(7):1700–1708, 2019) by expanding the scope to fungal pathogens. Both fungal species employed in this study—Alternaria solani and Botrytis cinerea—cause substantial crop and economic losses. Sodium magnesium chlorophyllin (Chl, approved as food additive E140) in combination with Na2EDTA and the chlorin e6 derivative B17-0024 holding cationic moieties serve as eco-friendly photoactive compounds. Effectiveness of the antifungal PDI was measured by inhibition of growth of mycelial spheres (average diameter 2–3 mm) after incubation with the photosensitizer for 100 min and subsequent illumination using a LED array (395 nm, 106.6 J cm−2). One hundred micromolar Chl combined with 5 mM Na2EDTA was able to successfully photokill 94.1% of A. solani and 91.7% of B. cinerea samples. PDI based on B17-0024 can completely inactivate A. solani at 10 times lower concentration (10 µM); however, for B. cinerea, the concentration required for complete eradication was similar to that of Chl with Na2EDTA (100 µM). Using a plant compatibility assay based on Fragaria vesca, we further demonstrate that both photosensitizers neither affect host plant development nor cause significant leaf damage. The plants were sprayed with 300 µL of treatment solution used for PDI (one or three treatments on consecutive days) and plant growth was monitored for 21 days. Only minor leaf damage was observed in samples exposed to the chelators Na2EDTA and polyaspartic acid, but overall plant development was unaffected. In conclusion, our results suggest that sodium magnesium chlorophyllin in combination with EDTA and B17-0024 could serve as effective and safe photofungicides.

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The Practice and Problems of Transnational Counter-Terrorism
Authors: de Londras Fiona
Published: January 2022

The attacks of 9/11 kickstarted the development of a pervasive and durable transnational counter-terrorism order. This has evolved into a vast institutional architecture with direct effects on domestic law around the world and a number of impacts on everyday life that are often poorly understood. States found, fund and lead institutions inside and outside the United Nations that develop and consolidate transnational counter-terrorism through hard and soft law, strategies, capacity building and counter-terrorism 'products'. These institutions and laws underpin the expansion of counter-terrorism, so that new fields of activity get drawn into it, and others are securitised through their reframing as counter-terrorism and 'preventing and countering extremism'. Drawing on insights from law, international relations, political science and security studies, this book demonstrates the international, regional, national and personal impacts of this institutional and legal order. Fiona de Londras demonstrates that it is expansionary, rights-limiting and unaccountable.
Innovation and Perceived Corruption: A Firm-Level Analysis for India
Authors: Dutta Nabamita , Kar Saibal , Beladi Hamid
Published: January 2022

Do perceived obstacles about corruption matter for Indian firms when it comes to their probability to innovate? Using World Bank Enterprise Survey firm-level data, we show that a unit rise in corruption perception of firms in India lowers innovation rate by about 1 percent. The result is important in terms of policy implementation because recent studies have shown that perceived obstacles can affect firms’ probability to innovate. Such analysis is missing in the Indian context where both big and petty corruption is rampant. Our results further show that perceptions about financial barriers matter only when firms also view corruption to be bad. Perceived difficulty in accessing credit in conjunction with corruption perception lowers probability of innovation by 4 percent. This is also true for nonfinancial perceived obstacles of firms. The results remain robust to alternate identification strategies.
Citizenship and COVID-19: Syndemic Effects
Authors: Shaw Jo
Published: January 2022

This article begins the task of outlining the impacts of the COVID-19 pandemic in relation to matters of citizenship, using what is termed a “syndemic analysis.” This type of analysis places both the pandemic and citizenship in their wider contexts. The synergistic or intersectional thinking encouraged by the characterization of the pandemic as a syndemic, which links together health, socio-economic issues, and political questions, is useful for highlighting how much more vulnerable to many of the negative impacts of the pandemic in the sphere of citizenship are those who are also more vulnerable both to catching and suffering more seriously from the virus and to experiencing negatively the externalities of the measures taken to restrict social contact by shutting down economies. While the scope of the review is relatively broad and encompasses many different domains of “pandemic life,” what emerges from the analysis are important insights into how many of the impacts of the pandemic in fact operate at the intersection of citizenship and constitutional law and thus play out in the form of changes in relation to constitutional citizenship, both as ideal and as practice. The article takes an important step towards developing the use of constitutional citizenship as a framing device for understanding citizenship as putative full membership in a given society.
Of Carbon Budgets, Factual Uncertainties, and Intergenerational Equity–The German Constitutional Court’s Climate Decision
Authors: Buser Andreas
Published: January 2022

The German Federal Constitutional Court’s climate decision provides a nuanced acknowledgment of climate change’s constitutional relevance. In this Article, the author critically assesses how the Court innovatively sought to capture the intergenerational equity dimension of climate mitigation through a combination of negative and positive duties stemming from constitutional law. The Article demonstrates how despite progressive findings on intergenerational equity and the innovative invocation of negative duties, the operative part of the decision turned out to be rather limited. Because of remaining uncertainties about the allowable national carbon budget, the Court was unable to require the legislator to enact a stricter reduction path. The author argues that the Court could have narrowed remaining uncertainties, without engaging in judicial activism, by adopting an international and constitutional minimum approach to calculating the national budget and by adjusting the burden of proof. Finally, the Article highlights how the German legislator, by going beyond what was required by the Court “trapped itself” on an ambitious reduction path, opening opportunities for future constitutional complaints.
Advancing Strategic Climate Litigation in Brazil
Authors: Lehmen Alessandra
Published: January 2022

Climate change has become a household term. As the climate crisis grows increasingly pressing, climate litigation has proven instrumental as a driver for change. Brazil is an important jurisdiction for climate matters: It is the sixth largest global greenhouse gas emitter, responsible for 3.2 percent of global emissions,1 and home to the largest extension of the Amazon rainforest. Climate litigation has been gaining traction, but it is still far less frequent than environmental litigation at large. Against the backdrop of the state and trends of climate litigation in the country, this article explores theoretical and practical avenues to further expand the strategic deployment of climate cases in Brazil. First, it analyzes how climate claims can be construed with arguments that are impervious to the political question doctrine. Second, it explores possibilities of bringing claims against private entities, challenging more granular obligations arising out of Environmental, Social and Governance (ESG) frameworks. Third, it discusses the role of lawyers in bridging theoretical and practical gaps, namely those between environmental law and climate law, between scientific experts and courts, and between international and domestic climate change regimes.
How Do Voters Evaluate Performance in Opposition?
Authors: Stiers Dieter
Published: January 2022

Recent scholarship on retrospective voting has shown that when they go to the polls, voters evaluate not only incumbent performance, but also the performance of parties in opposition. So far, however, these studies have not been able to identify how voters evaluate the performance of parties in opposition. The answers to a unique open-ended question included in a Belgian electoral survey in 2019 provide new insights into voters' minds. First, this study investigates what voters think about when they evaluate a party's performance in opposition. Second, it tests whether voters hold opposition parties responsible for the state of affairs in the country. The results show that voters are most concerned with opposition parties' competence in scrutinizing the government and providing constructive criticism, and dislike unconstructive and overly negative opposition. Furthermore, voters hold opposition parties accountable for the state of affairs in their country, albeit to a lesser extent than incumbent parties.
Potential anti-inflammatory effects of legumes: a review
Authors: Juárez-Chairez Milagros Faridy , Meza-Márquez Ofelia Gabriela , Márquez-Flores Yazmín Karina , Jiménez-Martínez Cristian
Published: January 2022

Legumes are a staple of diets all around the world. In some least developed countries, they are the primary source of protein; however, their beneficial properties go beyond their nutritional value. Recent research has shown that legumes have bioactive compounds like peptides, polyphenols and saponins, which exhibit antioxidant, antihypertensive, anti-inflammatory and other biological activities. Thus, these compounds could be an alternative treatment for inflammatory diseases, in particular, chronic inflammation such as arthritis, obesity and cancer. Nowadays, there is a growing interest in alternative therapies derived from natural products; accordingly, the present review has compiled the bioactive compounds found in legumes that have demonstrated an anti-inflammatory effect in non-clinical studies.
The Gospel of John and Antiochene christology: The diverging paths of Theodore of Mopsuestia and John Chrysostom
Authors: Edwards Robert
Published: January 2022

This article questions the value of the categories ‘the school of Antioch’ and ‘Antiochene christology’ on the basis of the significant theological differences between the two central figures in the school: John Chrysostom and Theodore of Mopsuestia, both of whom studied together at the school of Diodore of Tarsus in the late fourth century. Drawing on scholarship which has pointed to the coherence of Theodore's exegesis and christology, I show that Chrysostom's exegesis and christology are also coherent, but in a way which is at odds with those of Theodore. As opposed to Theodore's distinctions between the two testaments and between the human and the divine in Christ, Chrysostom has a strongly unitive reading of scripture's two testaments and of the person of Christ. In my argument I especially employ Theodore's and Chrysostom's respective exegetical works on the Gospel of John.
Adolf Schlatter on recasting theological anthropology
Authors: Bräutigam Michael
Published: January 2022

Adolf Schlatter claims that the Protestant Reformation bequeathed us a lopsided understanding of human personhood. In his view, the Reformers offered a limited definition of sin that neglected our creatureliness, and a passive understanding of grace that rendered the believer inactive. Seeking to correct what he considers misrepresentations of religious and christological anthropology in (post-)Reformation theology, Schlatter suggests a view of sin that takes our humanity as God's creatures seriously, and he puts forward a view of grace that leads to an organic transformation of our volition and leaves our God-given creatureliness intact. Schlatter's active-volitional understanding of divine grace offers much by way of promise as we rediscover our responsibilities as God's active agents in a fallen world.
The image of Christ in John Henry Newman's religious epistemology
Authors: Heffley Mark
Published: January 2022

On what rational grounds can one say that Christianity is true? John Henry Newman's answer to this question lays great emphasis on the subjective, personal dimensions of knowledge, which he claims are no less reasonable than formal logical argumentation. Among these dimensions is conscience. The clearest proof for God's existence, Newman argues, is provided by the experience of God in one's conscience. In this article, I will argue that there is another similar element of Newman's thought: the immediate encounter between Christ and the mind through the impress of the image of Christ. What conscience is to the certainty of God's existence, this image of Christ is to the certainty of Christianity.