bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Stakeholder Engagement for Electrification Success
Authors: Marcel Nzamurambaho , Amolo Amolo Elvis Juma
Published: February 2025

S
Stakeholder engagement has been indicated as great driver for successful electrification projects in many countries, including settings similar to Rwanda. However, little is known about its influence on electrification projects in Rwanda. The purpose of this study was to evaluate how different strategies of stakeholder engagement influence performance of electrification project Musanze District, Rwanda, with a focus on RUEAP. Specific focus was on collaboration strategy, involvement strategy, empowerment strategy and consultation strategy. Stakeholder theory and Goal Setting Theory informed the study. The study used descriptive survey and correlational research designs. A structured questionnaire and interview guide were used to collect quantitative data from 452 participants who were selected using Stratified, random and purposive sampling from a target population of 4691. The questionnaire was piloted with 47 participants, representing 10% of the sample size. The Validity of instrument was done and the coefficient of 0.8 was obtained. Reliability was established using Cronbach’s alpha test, and a Cronbach’s alpha coefficient of 0.899 was found. Descriptive statistics and inferential statistics of Correlation and Regression were done at a significance level of 0.05 using SPSS version 28 while thematic content analysis of qualitative data was done on qualitative data.  The findings for four hypotheses were tested at ?=.05 level of significance and the results were: stakeholder collaboration (P=0.011<0.05); stakeholder involvement (P=0.015<0.05); stakeholder empowerment (P=0.000<0.05) and; stakeholder consultation (P=0.007<0.05) does not significantly influence performance of electrification projects were rejected, confirming that they all had a significant influence on project performance. The study concludes that Stakeholders’ engagement in electrification project in Musanze have significantly influenced the electrification project performance. It is recommended that RUEAP project should continue to prioritize stakeholder engagement during the implementation of the project, but greater emphasis must be considered to begin engagement during the planning stage to ensure that the project aligns with public needs and expectation. Future research should involve a nationally representative sample of stakeholders would paint a picture of how engagement influence performance that is generalizable to other settings across Rwanda.
SalmoGlob – Un nouveau modèle pour l’évaluation des stocks de saumon atlantique à l’échelle de l’Atlantique Nord
Authors: RIVOT Étienne , OLMOS Maxime , LEMAIRE-PATIN Rémi , HERNVANN Pierre-Yves , NEVOUX Marie , PRÉVOST Étienne , BUORO Mathieu , BEAULATON Laurent
Published: February 2025

Le projet SalmoGlob mené au sein de l’unité mixte de recherche DECOD et du pôle MIAME, en partenariat avec le groupe de travail sur le saumon de l’Atlantique Nord du Conseil International pour l’Exploration de la Mer (ICES/CIEM WGNAS), a significativement renforcé les bases scientifiques de l'évaluation des stocks de saumon atlantique (Salmo salar) de l’Atlantique Nord. Un nouveau modèle a été développé pour analyser la dynamique des populations de saumon atlantique de l’ensemble des vingt-cinq unités de gestion (UG) des trois complexes de populations de l’Atlantique Nord : sud-européen, nord-européen et nord-américain. Il intègre plusieurs sources de données hétérogènes disponibles dans toutes les UG depuis 1971. Il peut être étendu pour mieux représenter la démographie et assimiler de nouvelles sources de connaissances et de données. Il représente la dynamique des populations sous la forme d’un modèle structuré en âges et stades de vie, ce qui permet d’intégrer les connaissances disponibles sur la biologie et l’écologie de l’espèce et de représenter l’effet des pressions environnementales à différentes échelles et stades de vie. Le modèle aide à comprendre et à prédire l’effet des changements globaux sur la dynamique et la productivité des populations, et à évaluer des scénarios de gestion de l’exploitation par la pêche dans un cadre probabiliste prenant en compte l’ensemble des sources d’incertitude. Une suite logicielle et une application web ont été développées pour simplifier et renforcer la robustesse de l’ensemble de la chaine de traitement des données jusqu’aux résultats. Ce nouveau modèle représente un saut qualitatif important par rapport aux outils d’évaluation précédents. Il permet d’améliorer la qualité de l’avis scientifique rendu sur l’état des populations pour éclairer la gestion dans le contexte de l’adaptation aux changements globaux. Ce nouveau cadre de modélisation a été officiellement adopté pour l’évaluation internationale du saumon par le CIEM en 2024.
Classification of Sagittal Spinopelvic Deformity Predicts Alignment Change After Total Hip Arthroplasty
Authors: Buckland Aaron J. , Ani Fares , Balouch Eaman , Zhong Jack , Vigdorchik Jonathan , Schwarzkopf Ran , Protopsaltis Themistocles
Published: February 2025

Background:

Changing from standing to sitting positions requires rotation of the femur from an almost vertical plane to the horizontal plane. Osteoarthritis of the hip limits hip extension, resulting in less ability to recruit spinopelvic tilt (SPT) while standing and requiring increased SPT while sitting to compensate for the loss of hip range of motion. To date, the effect of total hip arthroplasty (THA) on spinopelvic sitting and standing mechanics has not been reported, particularly in the setting of patients with coexistent sagittal plane spinal deformity.

Methods:

A retrospective review was performed of patients ≥18 years of age undergoing unilateral THA for hip osteoarthritis with sitting and standing radiographs made before and after THA. Alignment was analyzed at baseline and follow-up after THA in both standing and sitting positions in a relaxed posture with the fingers resting on top of the clavicles. Patients were grouped according to the presence or absence of sagittal plane deformity preoperatively into 3 groups: no sagittal plane deformity (normal), thoracolumbar (TL) deformity (pelvic incidence-lumbar lordosis [PI-LL] mismatch > 10° and/or T1-pelvic angle [TPA] > 20°), or apparent deformity (PI-LL ≤ 10° and TPA ≤ 20°, but sagittal vertical axis [SVA] > 50 mm).

Results:

In this study, 192 patients were assessed: 64 had TL deformity, 39 had apparent deformity, and 89 had normal alignment. Overall, patients demonstrated a reduction in standing SVA (45 to 34.1 mm; p < 0.001) and an increase in SPT (14.6° to 15.7°; p = 0.03) after THA. There was a greater change in standing SVA (p < 0.001) among patients with apparent deformity (−29.0 mm) compared with patients with normal alignment (0.9 mm) and patients with TL deformity (−16.3 mm). Those with apparent deformity also experienced the greatest difference (p = 0.03) in postural SPT change (moving from standing to sitting) (−10.1°) from before to after THA when compared with those with normal alignment (−3.6°) and TL deformity (−1.2°). The difference in postural SVA change from before to after THA was also greatest (p < 0.001) in those with apparent deformity (32.1 mm) compared with those with normal alignment (6.5 mm) and TL deformity (17.3 mm).

Conclusions:

Postural changes in spinopelvic alignment vary after THA depending on the presence of TL deformity or apparent deformity due to hip flexion contracture. Patients with apparent deformity had larger changes in standing and sitting alignment than patients with TL deformity or patients with normal alignment. The assessment of global sagittal alignment findings can be used to predict the likelihood of improvement in sagittal alignment after THA.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
A Rare Cause of Lateral Antebrachial Cutaneous Neuropathy Secondary to Internal Fixation of a Supracondylar Humeral Fracture
Authors: DeMartini Stephen J. , Dy Christopher J. , Brogan David M.
Published: February 2025

Case:

We discuss a patient with a 6-month history of episodic elbow and forearm pain 6 years after supracondylar humeral fracture fixed with Steinmann pins at the age of 10 years and 5-year follow-up data at the age of 21 years. Electrodiagnostic studies exhibited no response from the lateral antebrachial cutaneous (LABC) nerve, and anesthetic injection demonstrated relief. Surgical intervention provided immediate relief of symptoms without recurrence for 5 years postsurgery.

Conclusion:

Atypical LABC neuromas can be found after operative fixation of supracondylar humerus fractures. Neuroma excision and intramuscular burying of affected nerve ends remains a viable treatment option for patients with late-presenting traumatic neuromas.
Sanchez v. France: protection from hate speech or one more step by the ECtHR toward curbing free expression on the Internet?
Authors: Soboleva Anita
Published: February 2025

The article provides commentary on the recent ECtHR judgement Sanchez v. France, which is the third one, after Delfi AS v. Estonia and МТЕ и Index.hu Zrt v. Hungary, where the liability of an Internet site owner for a third party’s comment was the main issue. The ECtHR did not find a violation of Article 10 in the case of French politician Julien Sanchez, who had been convicted for incitement to hatred and violence against the Muslim community in France for failure to promptly delete comments posted by two individuals on the wall of his publicly accessible Facebook account. The judgement was immediately criticized by media lawyers and journalists, who regarded it as one more step toward curbing free expression and an attempt to restrict the use of social media as a platform for exchanging views on matters of public interest. The article discusses the Sanchez case in the context of previous ECtHR practice concerning freedom of expression and hate speech; analyzes differences in the Court’s approaches to defamation cases and hate speech cases in the light of the admissibility of content-based restrictions; draws attention to the blurry line between offending, shocking or disturbing statements, one the one side, and humiliating statements based on religious or ethnic identity, on the other side; and argues that these factors make the search for a balance between free expression and protection from hate speech rather difficult. It concludes that the ECtHR left space for interpretation of its Sanchez judgement, and in the future the Court will have to deal with the questions whether the duty to read all the comments to posts and delete those in conflict with the law may be imposed not only on politicians and commercial media providers, but on all users as well; whether this duty should depend on the number of followers and/or accessibility to the general public rather than solely for approved “friends”; and, finally, what time period should be understood to be “prompt” for deleting the content containing incitement to hatred. There is a risk that the disputed judgement in Sanchez will cause “a chilling effect” causing popular account owners to close their posts to comments or to delete their social media accounts entirely in order to avoid criminal charges, thus depriving the public of the opportunity to communicate with politicians and other public figures on a wide range of important issues. In addition, the authors of the posts, just to be on the safe side, will avoid any potentially troublesome content and will reduce the number of topics they write about. As a result, the most disputed questions will remain outside of public online discussions.
Public figures and the right to private life in the cyber era
Authors: Gerashchenko Alyona
Published: February 2025

The term “public figure” in legal doctrine, judicial practice, legal normative acts is hard to define. A public figure is often defined by enumerating examples such as politicians, public activists, outstanding athletes, artists, and persons who have a significant impact on the formation of public opinion. In the era of digitalization, when almost everyone has access to the Internet, anyone can “ascend” to the status of a public figure in a short time. In the digital age it is a rare public figure who does not seek to use easily accessible and large-scale information resources (like social networks) to maintain their status. The involvement of any person in the Internet space is great, so that chances of violation of private life increase, and public figures are no exception. Moreover, in the author’s opinion, the latter become most vulnerable to intrusion into their private life, where limits are significantly narrower in comparison with limits of the private life of people who do not play important social roles. At the same time, the mere fact that a person is a public figure does not mean that his right to privacy can be automatically violated. Frequently, freedom of speech and the right to information outweigh the right to private life of a public figure, but the process of evaluating each case should not so much be affected by the status of the person, but rather by the correlation between the rights and the permissible degree of restriction of each of them. However, in order to identify such a correlaion, it is necessary to have an idea of who is a public figure. In this article, the author examines the American doctrine of public figures, German and Russian approaches to the understanding of public figures, as well as the approaches of the European Court of Human Rights. The author proposes abandoning the method of defining the category of “public figure” by listing its various examples, in favor of highlighting the criteria that must be met in order for a person to acquire the legal status of a “public figure”. The list of criteria, in the author’s opinion, can clarify the relationship between private and public spheres and have a positive effect on the legal application of these concepts.
Reforming domestic remedies against human rights violations in the Russian Federation: general and specific issues
Authors: Filatova Maria , Fokin Evgeniy
Published: February 2025

The article is an analysis of the dynamics of domestic remedies against human rights violations in the Russian legal system in recent years. The State’s obligation to create effective domestic remedies for the protection of human rights and freedoms is established by the basic international documents on human rights protection and reflects the interaction between national and international levels of such protection. These obligations of the State are an illustration of the subsidiarity principle that lies at the foundation of international mechanisms of human rights protection. Moreover, the effectiveness of domestic remedies is closely linked to the enforcement of international courts’ judgments on the adoption of general measures to get rid of systemic/structural problems, as general measures normally presume the creation of effective national mechanisms to solve them. In the case-law of the ECtHR domestic remedies are divided into preventive and compensatory ones, and it is a combination of both that ensures the necessary level of effectiveness. Besides, there may be general or special remedies, depending on the scope of rights and freedoms whose violations they are called upon to prevent. In the Russian legal system we observe synchronisation of general (judicial) means of human rights protection which must be exhausted before lodging an application with the European Court of Human Rights. If earlier these means varied in accordance with the type of proceedings — from appeal up to supervisory review — currently cassation appeal has been recognised by the ECtHR as an effective remedy in all types of proceedings. As a result, is should be exhausted before applying to Strasbourg. The last example of this kind was in the decision Anikeyev and Ermakova v. Russia on the admissibility of a complaint arising from the new cassation appeal in criminal proceedings. However, the question of supervisory review proceedings in their new format and of the effectiveness of procedures in misdemeanour (administrative) proceedings remain open. As regards specific remedies relating to particular types of human rights and freedoms, the Committee of Ministers of the Council of Europe distinguishes systemic problems that call for the adoption of general measures from improvement of domestic remedies against violations of human rights. To illustrate this in the article, the authors have chosen cases on disappearances in the North Caucasian region and beyond it. The enforcement of ECtHR’s judgments in this type of case is particularly complex as it implies the adoption of a whole set of various measures — both individual and general — the list of which goes well beyond measures of only a legal nature. It produces particular difficulty in enforcing this group of judgments.
Fluoride content in table salt from the Element Project in Mexico City
Authors: Tamayo-Cabeza Guillermo , Mantilla-Rodríguez Andrés , Cantoral Alejandra , Téllez-Rojo Martha M , Peterson Karen E , Hu Howard , Martínez-Mier Esperanza Ángeles
Published: February 2025

Objective. This study evaluated fluoride content in table salts from participants’ households of the Element project, comparing them with the Mexican standards of fluoride content in table salt (200 to 250 mg/kg). Materials and methods. Salt samples were collected from households of mother-offspring pairs participating in Element. Salt samples were analyzed in duplicates using a combination fluoride ion-selective electrode and a pH/ISE meter. Results. Among 657 samples from 14 brands, fluoride varied from 0.016 to 477.9 mg/kg with a median (IQR) of 142.5 (136.9). Of salts labeled as fluoridated or containing fluoride (n= 607), we found that 72.8% (n= 442) had fluoride content below the recommended range and 13.8% (n= 84) were above the Mexican norm. Only 81 salt samples (13.3%) fell within recommended limits. Conclusion. Future studies with representative sampling are needed to evaluate table salt fluoride content, especially in high-fluoride areas, to inform potential adjustments to the current monitoring program.
Functional food consumption preference in Culiacán, Mexico
Authors: López-Cardoso Fernando , Ontiveros-Apodaca Noe , Gutiérrez-Grijalva Erick Paul , Arámburo-Gálvez Jesús Gilberto , Figueroa-Salcido Oscar Gerardo , Leyva-López Nayely , Gastélum-Chavira Diego A , Cárdenas-Torres Feliznando Isidro , Heredia J Basilio
Published: February 2025

Objective. To determine functional food consumption preferences in Culiacán, Mexico. Materials and methods. A survey was designed, validated, and implemented to gather information on functional food consumption. Associations between health conditions and functional food consumption were evaluated. Using the Borda count methodology, the preference order of different functional foods was identified, seeking statistical differences between preferences. Results. A validated questionnaire was obtained for the survey application. Association was found between having a diagnosed illness, undergoing medical treatment, and sex with awareness of functional foods; however, no association was observed between having a diagnosed illness and potential functional food consumption. The top three preferred foods were beverages, bars, and yogurt, with taste being the most important characteristic for functional food consumption. Conclusions. There is low consumption of functional foods, which may be associated with various factors. In designing and developing functional foods, it is important to consider preferences such as beverages, bars, and yogurts, emphasizing consumer taste acceptance.
Mexico's Health System, 2023
Authors: Gómez-Dantés Octavio , Serván-Mori Edson , Cerecero Diego , Flamand Laura , Mohar Alejandro
Published: February 2025

The public sector includes social security institutions and institutions that provide services to the population without social security. The private sector includes private insurance companies and service providers working in private offices, clinics, and hospitals. Longer lifespans and exposure to risks associated with unhealthy lifestyles have transformed the leading causes of disease and death. Chronic non-communicable diseases and injuries are increasingly prevalent in the health profile. Health system coverage improved over the last two decades, from less than 50 million people with health insurance in 2000 to over 100 million in 2016. Healthcare in Mexico is financed with public and private resources. Public resources finance partially the institutions that serve the population with contributory health insurance and fully those that serve the population without this labor benefit. Health spending represents 5.5% of gross domestic product. There are 34 756 healthcare units in Mexico. The ratio of doctors per thousand inhabitants is 2.5. Healthcare regulation activities include accreditation of health sciences schools and faculties, licensing and certification of physicians and nurses, and certification of healthcare units. The Comisión Federal de Protección contra Riesgos Sanitarios is responsible for health regulation.
El ensayo diana para la inferencia causal en estudios observacionales
Authors: Núñez Isaac , Lajous Martín
Published: February 2025

El uso de estudios observacionales para inferencia causal es una necesidad, ya que no siempre se cuenta con ensayos clínicos aleatorizados. Para reducir las fuentes de sesgo presentes en estudios observacionales “clásicos” se ha propuesto utilizar el marco de referencia del ensayo diana. Esto es, primero definir los siguientes componentes del protocolo del ensayo clínico pragmático (el ensayo diana) que respondería nuestra pregunta de investigación: criterios de elegibilidad, estrategias de tratamiento, métodos de asignación, periodo de seguimiento, desenlace, contrastes causales y plan de análisis. Posteriormente, estos componentes se modifican con base en los datos observacionales disponibles y se utilizan para emular al ensayo diana lo más de cerca posible. Esto resulta en estudios observacionales con menos sesgo y resultados más confiables. Sin embargo, siguen tratándose de estudios observacionales y no de experimentos aleatorizados, lo cual les confiere algunas limitaciones.
“One of the most prolific smut writers on Tumblr”
Authors: Reed Khaliah
Published: February 2025

Most fanfiction writers never imagine the worlds they create could become television content. However, many were confronted with this possibility in the third episode of HBO’s Euphoria (2019). Kat Hernandez, a social outcast, became a well-known writer on Tumblr for her fanfiction about Harry Styles and Louis Tomlinson from One Direction. Her story, "The First Night," was brought to life through an explicit one-minute technicolour animation. This article examines the reactions to both the animation and the specific fan practice of Real Person Fanfiction (RPF) highlighted by the episode. By analysing the reactions of three groups—One Direction fans, subscribers to the "Larry Stylinson" narrative, and non-One Direction fanfiction writers—this article demonstrates how fans perform contested fan practices and (attempt to) mediate which aspects are visible to the mainstream and other fans through specific fan personas. Drawing on scholars like Christopher Moore, Mark Stewart, CarrieLynn D. Reinhard, Celia Lam and Jackie Raphael, this article investigates how idealized fan performances, often weaponized against fandom by mainstream culture, are also used internally to regulate behaviour.
Regulation of Active Hydrogen and Nitrate Concentration: Pulsed Potential Strategies in Nitrate Electroreduction Microenvironments
Authors: Yang Jianping , Gu Lin , Song Nan , Wu Ziyang , Luo Hongxia , Chen Jun
Published: February 2025

The electrochemical reduction of nitrate (NO3RR) plays a significant role in the nitrogen cycle and environmental remediation. The dynamics of active hydrogen in the NO3RR were studied in depth by varying the nitrate concentration and applying a pulsed-potential approach. The effect of both factors on regulation of the degree of hydrogenation of the intermediates and the product distribution was evaluated. Density functional theory (DFT) calculations indicated that elevated nitrate levels decrease the energy barrier for *NO to *N conversion, enhancing *N2 formation. The experimental results indicate that under high nitrate concentrations, copper-palladium (CuPd) catalysts exhibit faster reaction kinetics and higher nitrogen selectivity. In-situ characterizations illuminated the critical role of active hydrogen on reaction intermediates. The CuPd catalyst achieved 95% NO3-N conversion and 99% N2 selectivity at 1 M nitrate by pulse potential modulation of the active hydrogen concentration on the catalyst surface. Finite element analysis (FEA) verified that pulsed potentials modulate the local nitrate and hydrogen ion concentrations. The present work brings the NO3RR closer to practical applications, aiding in environmental protection and the balance of the nitrogen cycle.
Prompting of commercial climate
Authors: Meenal
Published: February 2025

A commonly expressed apprehension is that the advocacy efforts of corporations may impede the effective enforcement of ambitious climate policies. We measure the extent of commercial attitudes towards both mitigating and exacerbating climate change. Examine the prompting expenditures of publicly traded companies in the United States and determine the most prominent commercial advocates along with their underlying motivations. On average, companies allocate approximately $277,000 annually towards prompting efforts aimed at opposing climate-related policies, with a majority of this expenditure totalling $185,000 specifically directed towards supporting initiatives that are against climate regulations/climate prompting). Adversaries of climate action tend to have business models that contribute significantly to carbon emissions, whereas advocates for climate action are more inclined to demonstrate engagement in environmentally friendly innovation. Companies that allocate a higher budget towards initiatives aimed at mitigating climate change.Research suggests that prompting activities may result in higher returns, potentially due to the impact of a risk mechanism. Our findings are consistent with the growing perspective among investors that engaging in anti-climate prompting represents a financial risk.
Therapeutic Effect of Cisplatin-Loaded Polymeric Nanoparticles and Nimotuzumab Combination in Human Glioblastoma Cells
Authors: Kaga Elif , Korkmaz Serhat , Kaga Sadik
Published: February 2025

Objective
This study evaluated the combined therapeutic effects of cisplatin-loaded PEG-PLGA nanoparticles (CIS-PEG-PLGA) and nimotuzumab (NIMO) on glioblastoma (GBM) cells, focusing on their antiproliferative, apoptotic, and cell cycle-modulatory effects.
Materials and Methods
PEG-PLGA nanoparticles were synthesized using a double-emulsion solvent evaporation method, achieving a mean particle size of ~ 450 nm. Cisplatin release kinetics, proliferation, apoptosis, and cell cycle progression were assessed in U87 glioblastoma cells. The treatments included free cisplatin (CIS), CIS-PEG-PLGA, NIMO, and their combinations. Experiments were performed in triplicate, and statistical analyses included ANOVA test.
Results
The CIS-PEG-PLGA nanoparticles exhibited sustained cisplatin release, with 50% released within 8 h and nearly 100% within 72 h. The combination of CIS-PEG-PLGA + NIMO reduced cell proliferation by 90%, significantly surpassing that of CIS (50%) and CIS-PEG-PLGA (70%). Apoptosis rates were highest in the combination group (27.52%), followed by CIS (18.59%) and CIS-PEG-PLGA (25.95%). Cell cycle analysis revealed significant G2 phase arrest (30.12%) in the combination treatment group, highlighting its superior modulatory effects on cell cycle progression.
Conclusion
The combination of CIS-PEG-PLGA and NIMO demonstrated synergistic therapeutic effects in glioblastoma cells, enhancing antiproliferative, apoptotic, and cell cycle-modulatory outcomes. This approach represents a promising advancement in glioblastoma therapy by integrating nanotechnology and immunotherapy to overcome conventional treatment limitations. Further, in vivo studies are warranted to validate these findings and explore their clinical applications.
In silico design and characterization of an ISG75-derived chimeric protein from Trypanosoma evansi: a potential vaccine candidate
Authors: Neves Gabriella Bassi , Moreira Renato Simões , Alves Emanuelle Lemos , Scheffer Eduarda Karolyne , Miletti Luiz Claudio
Published: February 2025

Vaccination remains the most effective practical approach for controlling the spread of infections and alleviating the adverse health effects of diseases. Surra, caused by Trypanosoma evansi, affects various hosts, enabling the disease's continual transmission between its wildlife reservoir and domesticated or working animals. Furthermore, parasites utilize mechanisms such as antigenic variation to circumvent both innate and adaptive immune responses, thereby complicating the development and effectiveness of an anti-trypanosome vaccine. We used an in silico method to design a novel vaccine consisting of a chimeric protein that incorporates predicted epitopes of Invariant Surface Glycoprotein 75 (ISG75) of T. evansi to stimulate an immune response against the parasitic infection. The assessment of predictions was conducted utilizing VaxiJen and ANTIGENpro to facilitate the identification of four epitopes with antigenic properties. In the selected ISG75 sequences, we obtained scores between 0.7 and 1.4 on VaxiJen and between 0.15 and 0.57 with ANTIGENpro. The analysis of immunoinformatics, physicochemical characteristics of the chimeric protein, and molecular simulations indicate that the multiepitope vaccine may be efficacious and appropriate for in vitro evaluation, aiming to develop a peptide vaccine against T. evansi infection. The effectiveness of ISG75 as a vaccine candidate has been validated by multiple previous in silico experimental trials. Consequently, we propose an alternative multiepithope ISG75 vaccine for immunization against T. evansi. No chimeric protein has previously been evaluated against any salivarian trypanosomes.
Efeitos da Taxa SELIC nos Investimentos das Empresas de Capital Aberto
Authors: Santos Raidan Iago dos , Negreiros Luiz Alberto Frezzatti , Gomes Matheus da Costa , Ambrozini Marcelo Augusto
Published: February 2025

Este estudo buscou analisar o impacto da taxa de juros nos investimentos realizados pelas empresas brasileiras de capital aberto. A pesquisa fundamenta-se nos pressupostos da Teoria dos Juros, a qual postula que a elevação da taxa de juros faz com que as empresas sejam desestimuladas a realizar investimentos, resultando em uma menor geração de riqueza e, consequentemente, retardação no crescimento econômico do país. Para atingir tal objetivo, foram coletados dados da base de dados da Economática® e, com essas informações, realizaram-se regressões com dados em painel para uma amostra de 325 empresas listadas na Brasil, Bolsa, Balcão [B]3 no período de 2013 a 2022, totalizando 8.500 observações. Os resultados indicaram que a taxa SELIC possui relação positiva com os investimentos realizados pelas empresas no período, depreendendo-se que quanto maior o percentual da taxa de juros, maiores investimentos as organizações realizaram, achado este que vai de encontro ao que expõe a Teoria dos Juros. Ademais, durante a instabilidade econômica as empresas tenderam a reduzir os aportes realizados em ativos permanentes. Em termos teóricos, a pesquisa contribuiu por meio da utilização de uma variável contábil-financeira de investimentos, denominada Compras Líquidas de Ativos Permanentes (CLAP), haja vista que essa proxy ainda não havia sido utilizada em estudos desta temática e se mostra mais adequada em evidenciar os investimentos e desinvestimentos das companhias presentes no mercado de capitais. Dessa forma, as principais implicações da pesquisa são expandir as discussões em uma temática escassa e proporcionar reflexões sobre o comportamento das empresas em cenários econômicos críticos e o impacto desses aspectos para os acionistas.
Efeitos dos Diferentes Modelos de Classificação e Mensuração Contábil de Criptomoedas
Authors: Ferreira Eduardo Russolo , Oliveira Bruno Afonso de , Dantas José Alves
Published: February 2025

O presente estudo tem por objetivo analisar o impacto dos diferentes modelos de classificação e mensuração de criptomoedas nas demonstrações financeiras em termos de posição patrimonial, desempenho e análise econômico-financeira. O mercado de criptomoedas se desenvolveu de forma importante nos anos recentes, alcançando valor de mercado semelhante ao das bolsas de valores da Alemanha ou da Austrália. Na ausência ou insuficiência de normas específicas para contabilização de criptomoedas, os preparadores de relatórios financeiros se baseiam em orientações interpretativas e em uma diversidade de requisitos e princípios subjacentes aplicados nas diferentes jurisdições nacionais. A análise foi desenvolvida a partir de revisão de literatura e de teste prático, realizado por meio da simulação da contabilização de operações com criptomoedas. Como resultado, foi constatado que os diferentes modelos de classificação e de mensuração aplicados atualmente na contabilização de criptomoedas tornam as demonstrações financeiras incomparáveis e podem induzir os usuários a erros de interpretação. O estudo contribui para o ambiente de discussão, interpretação e aplicação de normas contábeis nas transações com criptomoedas e destaca a importância da contabilidade nas análises e no processo de tomada de decisões econômicas dos usuários. Adicionalmente, o estudo sugere um caminho para futuras regulações acerca do tema, além de indicar campos promissores para novas pesquisas.
The Herbicidal Potential of Euphorbia Species for Managing Common Weeds in the Mount Cameroon Region
Authors: Egbe Andrew Enow , Nsanyi Fritz Mukow , Ndam Lawrence Monah , Soupi Nkeutcha Marietta Solange
Published: February 2025

The utilization of botanicals in weed management is of great significance due to their biodegradability and eco-friendly nature. This research evaluates the herbicidal potentials of seven Euphorbia species (Euphorbia hirta, Euphorbia maculata, Euphorbia heterophylla, Euphorbia prostrata, Euphorbia pulcherrima, Euphorbia trigona, and Euphorbia milii) in the Mount Cameroon Region.The assessment of the herbicidal potential of the most promising Euphorbia species was conducted using the Sandwich method along with germination bioassay techniques. Qualitative phytochemical screening techniques were employed to investigate the herbicidal properties of E. heterophylla through the identification of classes of secondary metabolites. Additional analysis of Faculty of Agriculture and Veterinary Medicine, University of Buea, Cameroon, P.O Box 63, Cameroon. The crude extracts from Euphorbia heterophylla regarding the germination and development of five weed species revealed inhibiting effects on all the weeds examined. The results showed that Euphorbia heterophylla exhibited inhibitory effects on Lactuca sativa seeds, with a maximum inhibition of 85.75% at higher concentrations, indicating dose-dependent trends.  Bidens pilosa had the highest herbicidal suppression rate of 83.91%, while Mimosa invisa exhibited the least suppression at 61.10%. Thirteen (13) chromatographic fractions of Euphorbia heterophylla were tested for their influence on the germination and growth of Bidens pilosa seeds. The findings showed that fractions F4, F6, F7, and F13 demonstrated total inhibition of the weed (100% suppression). Phytochemical analysis of E. heterophylla identified the presence of flavonoids, phenolic compounds, alkaloids, tannins, steroids, saponins, and cardiac glycosides. Euphorbia heterophylla, had a strong allelopathic potential, making it viable candidate for the isolation and development of bioactive compounds. These compounds could be utilized as bioherbicides and thereby contributing to sustainable weed management in crop production.
GRANULOMETRIC ANALYSIS OF CHANNEL SEDIMENTS OF SATI RIVER BASIN, DISTRICT GADCHIROLI, MAHARASHTRA, INDIA
Authors:   P.G. Department of Geology, Sant Gadge Baba Amravati University, Amravati., Mawale Y.K. , Chikhalkar P.N. ,   P.G. Department of Geology, Sant Gadge Baba Amravati University, Amravati., Lede N.R. ,   P.G. Department of Geology, Sant Gadge Baba Amravati University, Amravati., Kasdekar M.M. ,   P.G. Department of Geology, Sant Gadge Baba Amravati University, Amravati., Jaipurkar R.S ,   Arts, Science and Commerce College, Chikhaldara.
Published: February 2025

Ten sediment samples from the Sati River basin in Gadchiroli District, Maharashtra, were analysed in detail for grain size to assess their textural and statistical characteristics, including mean, standard deviation, skewness, and kurtosis, as well as to understand their depositional patterns. The basin spans approximately 842.60 square kilometres, covering catchments from the northeast to the southwest. The sieve technique was used for grain size analysis, and a cumulative curve was generated by plotting grain size against cumulative weight percentage. The computed values for inclusive graphic skewness, median, mean, standard deviation, and kurtosis suggest that the sediments primarily consist of coarse-grained sand, are platykurtic, moderately sorted, and nearly symmetrically skewed. The interrelation of these parameters confirms the unimodal nature of the sediments, with coarse-grained sand being dominant. The C-M plot and log probability curves indicate that sediment transport occurs mainly through saltation and suspension. Overall, granulometric analysis confirms the fluvial origin of these sediments.
AIS IMPACT ON PERSONALIZING E-COMMERCE EXPERIENCES
Authors:   Md Asif Faizi Assistant Professor, MBA Department, Guru Gobind Singh Educational Societys Technical Campus, Bokaro, Jharkhand., Faizi Asif
Published: February 2025

The incorporation of Artificial Intelligence (AI) in e-commerce has transformed customer experiences by enabling highly personalized interactions. This paper explores how AI-driven technologies, including machine learning, natural language processing (NLP), and recommendation systems, enhance personalization in online retail. Through case studies and industry examples, we analyze how AI improves customer satisfaction, increases sales, and optimizes user engagement. Additionally, we discuss the challenges and ethical considerations associated with AI implementation in e-commerce, including AI-driven price discrimination, consent in data collection, and the environmental impact of AI computations.
V. C. Jernstedt’s “Brilliant Mistake”: Commentary of Classical Philologist on the Poem “Mustache” by A. S. Pushkin
Authors:   Archive of the Russian Academy of Sciences, Basargina Ekaterina Iu.
Published: February 2025

The publication in 1899 of the first volume of Alexander Pushkin’s works prompted the classical philologist Viktor Carlovich Jernstedt to re-read his lyceum lyrics, thoroughly imbued with ancient motifs. In Pushkin’s philosophical ode “Mustache”, written in 1816, Jernstedt’s attention was drawn to the line “where are the skinny dramas of Cleon?” and he dedicated a short note to it, which is being published and commented on for the first time. Here, Jernstedt made a witty guess that Pushkin was referring to the little-known ancient playwright Cleophon, but mistakenly wrote the name of the famous politician Cleon. Jernstedt wonders from what source Pushkin could have known about Cleophon. Lyceum students could get information about Aristotle’s “Poetics”, where the name of Cleophon occurs, from the first volume of Jean-François de La Harpe’s “Lycée ou cours de littérature ancienne et modern” (1799), which at that time was a manual for teaching literature. But the name of Cleophon is not found here, nor is it in the didactic work “L’art poétique” by Nicolas Boileau-Despréaux, available to lyceum students both in the original language and in Russian translation. The classical philologist overestimated, however, the cultural baggage of the lyceum poet, the vastness and depth of the lyceum education. Later, Pushkinists established that under the name of Cleon the mediocre poet A. A. Shakhovskoy, a contemporary of Pushkin, was hiding. Jernstedt approached Pushkin’s text from the viewpoint of a classical philologist, underestimating the cultural context of the era. Nevertheless, his mistake in itself is quite remarkable, and his questions indicate his intention to continue the research and point out the direction of future quest.
Beyond hydrologic benefits: post-occupancy evaluation of the Sponge City Construction in China, a case study of the Quyuan Park, Changde
Authors: Xu Hanwen , Randall Mark , Liu Yu , Xu Meng , Fryd Ole
Published: February 2025

The Sponge City Construction (SCC) attempts to provide a solution for coping with urban flooding and water-environmental issues in China. During the last decade, numerous SCC projects have been implemented in green spaces (so-called spongy green spaces) which combined hydrological benefits and socio-ecological benefits. Much research attention has been paid to hydrologic modeling as a pre-step of implementation. However, less attention is focused on evaluating and monitoring these projects after implementation. This study used post-occupancy evaluation (POE), combining analytic hierarchy process, fuzzy comprehension evaluation, and semi-structured interview methods to demonstrate the public perception of the Quyuan Park in Changde. The results showed the following: (1) Over 50% of responses for 31 out of 33 indicator questions were “strongly agree”, reflecting an overall positive evaluation; (2) air quality, plant growth, and physical well-being received the three highest satisfaction scores; (3) indicator scores for water management and service management category are relatively low; (4) dissatisfaction and improvements focused on needs for commercial facilities and children's playgrounds. The mismatch between technical objectives and respondent feedback implied a gap between SCC implementation and public awareness. The findings provide a reference and indicator framework of POE for policymakers, planners, and designers in the future.
Unidade de ensino potencialmente significativa norteada por metodologias ativas: uma proposta para o estudo de gases ideais na disciplina de física no ensino médio
Authors:   , Sousa Rejane Rodrigues de Oliveira
Published: February 2025

A escola, enquanto espaço social e ambiente destinado a produção do conhecimento sistematizado, não pode se alinhar a ideia de práticas de ensino que não corroboram com as expectativas de uma sociedade cada vez mais dinâmica. Neste sentido, torna-se necessário um novo fazer pedagógico que atenda aos anseios dos alunos. Diante de tal realidade, surge a inquietação e desejo de realizar este trabalho onde expomos a elaboração, aplicação e avaliação de uma sequência didática para o estudo de gases com alunos da 2ª série do ensino médio da rede estadual de ensino. A sequência didática está inscrita nos pressupostos da Teoria da Aprendizagem Significativa do norte americano David Ausubel como forma de superar antigas práticas, possibilitando o estudo de Física mais próximo da realidade dos alunos. A sequência didática, denominada Unidade de Ensino Potencialmente Significativa, é constituída por pré e pós testes, texto introdutório, questionário, mapas conceituais, vídeo-aulas e situações-problemas (estações) em conformidade com o desenvolvimento das competências e habilidades trazidas pelos Parâmetros Curriculares Nacionais (PCN e PCN+) e para Base Nacional Comum Curricular (BNCC). As metodologias ativas são norteadoras deste trabalho por favorecer o fortalecimento da autonomia, a sala de aula invertida oportuniza o aluno perceber que a produção do conhecimento pode ocorrer em um outro viés, quando ocorre a inversão do que é feito na sala de aula para ser feito em casa. As atividades colaborativas, promovem um ambiente de negociação de ideias, significados e conceitos. Este trabalho é de caráter qualitativo, quantitativo e experimental, por se tratar de um experimento de ensino, fundamentado teoricamente em trabalhos e pesquisas de Ausubel (1963, 1968); Moreira (2000, 2002, 2011); Freire (2005); Brasil (1999); Brasil (2002); Reeve (2009); Coelho (2018); Morin (2000); Moran (2015), “Cobb e Steffe (1983) dentre outros. Verificamos que os resultados da Unidade de Ensino Potencialmente Significativa corroboram com os pressupostos teóricos que fundamentam esse trabalho. A análise dos resultados de natureza qualitativa e experimental deu-se por meio do posicionamento dos alunos, da evolução dos mapas conceituais e das avaliações individual e somativa. Quanto aos resultados de natureza qualitativa, seguimos os parâmetros do Ganho de Hake. Desse modo, inferimos que é possível uma prática de sala de aula balizada por metodologias ativas influenciar positivamente na aprendizagem significativa de Física. Portanto, capacitar o professor para o uso de práticas que desenvolva nos alunos autonomia e habilidade intelectual para entender e solucionar situações reais, é contribuir significativamente no processo de ensinar e aprender
Diagnosis and Management of Group 2 Pulmonary Hypertension Due to Left Heart Disease in the UAE
Authors: Sabbour Hani , Saiari Mohammed B Al , Alzaabi Ashraf , Shehab Abdullah , Badaoui Hazem El , Ahmed Rizwan , Skouri Hadi , Khan Mohammad Daud , Harari Mohamed El , Tofeig Magdi , Agrawal Amrish , Zaky Hosam , Yaseen Noha , Mahmeed Wael Al , Taha Ahmed Reda , Kakar Vivek , Hennawi Yasser El , Satyanarayanan Yogeeswari Vellore , Hakami Aref Al , Zaabi Anwar Al , Heshmat Hussein
Published: February 2025

Pulmonary hypertension (PH) due to left heart disease (PH-LHD) is the most common type of PH and is observed in patients with underlying left heard disease conditions, including valvular heart disease, heart failure (HF) with preserved ejection fraction (HFpEF), (HF) with reduced ejection fraction (HFrEF), , cardiomyopathies and arrhythmic diseases.. Group 2 PH is postcapillary PH categorised into 2 components as isolated postcapillary PH (IpcPH) and combined precapillary and postcapillary PH (CpcPH), based on the value of pulmonary vascular resistance (PVR).

PH-LHD diagnosis is a 3-step process and includes identification of clinical phenotype, determination of pre-test probability for invasive evaluation and haemodynamic assessments. Management of PH-LHD primarily encompasses optimisation of treatment of underlying conditions such as hypertension, obesity and diabetes mellitus, , and treatment of PH-LHD with targeted PAH-specific drugs like phosphodiesterase type 5 inhibitors (PDE5i) and sildenafil.

The chapter aims to provide updated information on diagnosis and emerging treatment options for PH-LHD. Although the emerging alternative treatment options are not approved, the randomised studies discussed provide insight into the management and thus demand future clinical trials to establish the safety and efficacy of novel molecules and combination therapies.