bluuebunny/crossref_metadata_2025 huggingface dataset:
A COMPARATIVE RESEARCH ON META-DISCOURSE MARKERS USED IN INTRODUCTION SECTION ON LOCAL, NATIONAL AND INTERNATIONAL JOURNAL ARTICLES OF ENGLISH EDUCATION
Authors: M.Pd Hairiyanto , Harahap Alamsyah , Sofyan Dedi
Published: April 2022

This research aims to identify the meta-discourse feature mostly used and the difference between interactive and interactional categorize among Local, National and International Journals. This research was a corpora analysis employed journal articles as the object of the research. Data were collected purposive random sampling with a total of sampling were 30 articles taken three journals. The data is a cropped introduction section to be made a Microsoft file and processed by using the AntConce Application. Data were analyzed using a qualitative method by focusing on the use of the meta-discourse feature and different interactive and interactional categorized by Hyland�s (2005). The results show that: 1) The meta-discourse feature that is mostly used in each journal is interactive. The interactive has the same tendency used among Local, National and International journals. 2) The transition categorizes the most frequent in the Local, National and International Journal. 3) The meta-discourse feature that is least used was found in the Asian EFL Journal, the frame markers that are least used were found in Joall journals, and the endophoric that is the least used was found in Joall journals. 4) There are significant differences in the use of interactive and interactional in each journal. So it can be concluded that each writer has known and used meta-discourse in writing articles, the use of meta-discourse is not influenced by the level of journals, both Local, National and International Journal, but is influenced by the writer competence in expressing his thoughts, and the culture of the author's environment. Besides, the articles published in each journal are influenced by the editor of the journal itself.
An Analysis of Students� Comprehension in Pronouncing English Words by Using Song
Authors: Yuneva Yuneva , Melati Melati , Utami Elva , Masitah Siti , Syarayani Febrilia
Published: April 2022

The aimed of this research was to know the causes of pronunciation errors made by the students and whether the method of learning English prounciation using song can improve the student�s pronouncing English words at SMAN 8 Bengkulu. The method used in this research is a qualitative descriptive. The informants in this research were students from X IPS 1 Data collection is done by interview and quistionnaire. The data obtained were analyzed by reduction of data, presentation of data, and drawing conclusions.The research results show that most of studens of X IPS 1 more interested and understanding if learning English pronunciation using songs because they can follow a native speaker to say English words correctly. The causes error of their English pronunciation is a lack of their confidence when they speaking English and the media can also be an easy or difficult factor for students to learning English pronunciation. It can be concluded that is the right media for students English pronunciation.
Analysis of Educational Values in Tere Liye's �Hujan� Novel as Literary Teaching Materials in High School
Authors: Rakhmanina Lisa , Melati Melati , Haimah Haimah
Published: April 2022

Abstract

The objective of this research was to gain a deep understanding of the educational values in Tere Liye's novel, Hujan. This novel, Hujan, served as the basis for the research. The novel's educational values served as the research's data. The research method was descriptive qualitative. According to the study, Tere Liye's novel Hujan reflects educational values for his readers in the following ways: first, the moral value of education: always help, perseverance, and responsibility. Second, there is the value of social education in terms of humanity, caring, and empathy. Third, there is the value of cultural education in terms of mutual cooperation, obedient rules, and mutual respect. Tere Liye's Hujan was suggested as an alternative to literary teaching materials in high school.
Revisão integrativa: verificação da eficácia / efetividade da Cannabis medicinal e dos derivados canabinoides na Doença de Alzheimer
Authors: Moraes Poliana Zanoni de , Fukushima André Rinaldi , Nicoletti Maria Aparecida
Published: April 2022

Considerando os efeitos terapêuticos limitados das medicações atuais para a tentativa de tratamento ou diminuição dos sintomas da doença de Alzheimer, torna-se relevante a busca por novas alternativas terapêuticas, com eficácia significativa e efeitos colaterais diminuídos. Uma das soluções promissoras para impedir a progressão das alterações comportamentais e cognitivas da doença são os derivados canabinoides, nos quais estudos in vivo têm mostrado uma redução no estresse oxidativo, neuroinflamação, formação de placas amiloides e emaranhados neurofibrilares, além de estar relacionado com a regulação da ativação das células da microglia e liberação de macromoléculas, todos os fatores que quando presentes, contribuem para a piora e evolução da doença. A Cannabis medicinal e os derivados canabinoides como o canabidiol e o Δ9-tetraidrocanabinol têm mostrado eficácia terapêutica bastante significativa para variadas doenças e sintomas, como dor crônica, náusea e vômito induzidos pela quimioterapia, esclerose múltipla, anorexia nervosa, ansiedade, doença de Huntington, doença de Parkinson, epilepsia, doença de Alzheimer, entre outros. Sendo assim, esse trabalho teve como objetivo reunir estudos que possibilitassem a análise da eficácia/efetividade dos derivados canabinoides na doença de Alzheimer em publicações mais atualizadas.
Possíveis interações medicamentosas de fitoterápicos e plantas medicinais incluídas na relação nacional de medicamentos essenciais do SUS: revisão sistemática
Authors: Kirchner Giovanna de Albuquerque , Pelaquin Matheus Maschio , Magalhães Milena Ferreira , Gouveia Neire Moura de
Published: April 2022

O presente estudo trata-se de uma revisão sistemática sobre as possíveis interações medicamentosas do uso de plantas medicinais e fitoterápicos incluídos na Relação Nacional de Medicamentos Essenciais (RENAME). Para isso, foram pesquisadas as interações entre medicamentos alopáticos e as plantas medicinais: alcachofra, aroeira, babosa, cáscara sagrada, espinheira-santa, garra do diabo, guaco, hortelã pimenta, isoflavona de soja, plantago, salgueiro e unha de gato. Foram identificados inicialmente, 637 artigos, com uma seleção final de 61 artigos, desses os mais encontrados foram revisões de literatura (52%), estudos in vitro (23%), estudos em animais (11%), relatos de caso (7%), estudo descritivo observacional (5%) e ensaio clínico (2%). Verificou-se interações como, diminuição da absorção de medicamentos, interferência com enzimas do citocromo P450 e efeitos sinérgicos levando a toxicidade. Foram descritas diversas interações, tais como: varfarina e anticoagulantes com babosa, garra do diabo, guaco, isoflavonas de soja, plantago e salgueiro; diuréticos com alcachofra, babosa, cáscara sagrada e plantago; corticoides com babosa, cáscara sagrada e plantago; digitálicos ou digitoxinas com babosa, cáscara sagrada e plantago; anti-inflamatórios não esteroidas com garra do diabo e plantago. Verifca-se que o uso de fitoterápicos exige cautela a fim de evitar repercussões graves no que tange a possíveis interações.
Systematic review: Nursing navigator for the oncology patients care and its management [Revisión Sistemática: Navegador de enfermería para el cuidado y manejo en pacientes oncólogicos]
Authors: Osorio Calle Yuli Pilar , Sebastian Aquino Katterin Joely , Puchoc Melendez Miriam Lorena
Published: April 2022

Objective: To analyze the development of scientific evidence on the use of the nurse navigator for the care and management of oncology patients. Materials and method: An integrative review was conducted in the databases PubMed, Science Direct Cochrane Library and Scielo of publications generated between 2011 and 2021, using the key descriptors "navigator", "nurse" "oncology" "cancer" and their respective synonyms in English and Spanish". Results: Scientific evidence highlights the need for the use of nurse navigators to promote educational actions for the management and health care of continuing and new oncology patients with the aim of sustaining self-care during the disease process. Conclusions: It is important to implement this platform in health services as a strategy of technological innovation in continuity of care, in order to avoid risk of complications in their health and to be addressed in a timely manner, to be referred to competent personnel as appropriate.
An Analysis on How Artificial Light at Night May Impact the Sustainable Development Goals 2030 and Human Health
Authors: Jamal Md Shahrukh , Falak Shahkar , Khan Zeeshan Ahmad
Published: April 2022

This study addresses the relationship between Sustainable Development Goals (SDGs) 2030 and artificial light at night (ALAN). In this research paper, different types of SDGs by the United Nations are discussed regarding the effects of ALAN on different goals. In addition, different policies associated with ALAN around the world are examined, and literature reviews are discussed. With this analysis and additional stakeholder discussions, several suggestions are introduced to create a better environment. Regarding different sustainable goals, we observe a trade-off between SDGs and ALAN. It is necessary to discuss different stakeholders, to minimize the negative impact of light pollution and make better policies for the world. One cannot attain SDGs 2030 without considering ALAN. We hope this paper will be helpful to create better policies for sustainable development.
Association of Individuals’ Chronotypes With Obesity and Body Composition in Tehrani Adults in 2020
Authors: Sadeghzadeh Hakimeh , Haghgoo Mazyar , Rabiei Samira
Published: April 2022

Objective: Individual’s preferences in time for sleeping, waking up, doing physical and mental activity is dependent on chronotypes. According to these preferences, individuals are categorized to morningness, intermediate, and eveningness chronotype. Recently, it has been suggested that chronotypes are involved in regulation of sleep, appetite, and some metabolic factors. The aim of this study was to investigate the association between chronotypes, obesity, body fat, and lean mass in Tehrani adults.Methods: It was a cross-sectional study on 353 adults aged 18–60 years who referred to Tehran community centers. After anthropometric measurements and collecting data on general information, choronotype, physical activity and 3-day food recalls, fat mass, and lean mass were measured using the method of bioelectrical impedance analysis. SPSS 21 was used to statistical analysis.Results: Of total 353 participants, 11%, 47.6%, and 41.4% had eveningness, intermediate, and morningness chronotypes, respectively. The mean age of individuals with morningness and intermediate was higher than those with eveningness. The prevalence of eveningness in men was higher than in women (p=0.001). Fat mass and lean mass in individuals with eveningness type were higher and lower than those with morningness, respectively (p<0.05). Body mass index and waist circumference showed no significant difference among chronotypes.Conclusion: Eveningness type is associated with increase in fat mass and decrease in lean mass. The effects of chronotype on body fat and lean mass are independent of obesity.
The Reliability of the Thai Version of the Toddlers’ Temperament Questionnaire
Authors: Rojmahamongkol Pat , Tangvalelerd Supaluk
Published: April 2022

Objective: To evaluate the reliability of the Early Childhood Behavior Questionnaire (ECBQ)-very short form, Thai version; and to investigate Thai toddlers’ temperamentsMaterials and Methods: The English version of the very short form ECBQ was translated into Thai language. The primary caregivers of 360 healthy, 18-36 months old children, were asked to fill the questionnaire from the period of April, 2018 to June, 2019. The scores were calculated to determine the child’s temperament. The reliability of the very short form ECBQ- Thai version was assessed by Cronbach’s alpha coefficient for internal consistency and Intraclass correlation coefficient (ICC) for inter-rater reliability, two-week and six-month test-retest reliability.Results: The Cronbach’s alpha coefficients were 0.627-0.692, which indicated questionable internal consistency, but almost reach those of the original ECBQ. The inter-rater ICCs were 0.463-0.670, which were comparable to those in the original English version. The two-week ICCs were 0.602-0.750, which indicated moderate reliability, whereas the six-month ICCs decreased to 0.459-0.602. However, these values almost reached those of the original English version. Most toddlers were reported to have a surgency temperament. Boys significantly had more surgency temperament and had higher mean surgency scores, whereas girls exhibited a more effortful-control temperament.Conclusion: The very short-form ECBQ, Thai version can be implemented in assessing Thai toddlers’ temperament. The majority of Thai toddlers in this study demonstrated surgency temperament. Boys tended to be more surgency, while girls tended to be more effortful control.
Predictive Value of Right Ventricular Pressure Measurement for Residual Pulmonary Stenosis in Tetralogy Repair
Authors: Nitayavardhanam Prompak , Tocharoenchok Teerapong
Published: April 2022

Objective: The long-term outcome of tetralogy of Fallot repair depends on an adequate relief of right ventricular outflow tract obstruction and preservation of the pulmonary valve function. Since intraoperative transesophageal echocardiography is not routinely performed in small patients, we postulated that the post-bypass right ventricular pressure measured intraoperatively could predict residual pulmonary stenosis when evaluated by transthoracic echocardiography.Materials and Methods: Of the 187 patients who underwent tetralogy repair between 2012 and 2019 at Siriraj Hospital, Thailand, 95 with right ventricular pressure measurements and pre-discharge echocardiography were included in the study. Their intraoperative parameters, and postoperative outcomes were analyzed. The tolerable pressure cutoff was determined.Results: The median patient age was 3.9 years old (interquartile range 2.75–6). Fifty-three patients (54.6%) required the use of the transannular patch. Ten patients (10.3%) had significant residual pulmonary stenosis with a mean right ventricular systolic pressure of 64.0±10.6 mmHg compared with 48.7±14.4 mmHg for the other patients. There was an association between the pressure figure and the degree of residual pulmonary stenosis (rho=0.391, p=0.01). A systolic pressure above 49 mmHg predicted pulmonary stenosis with a likelihood ratio of 2.18 (1.94-2.80, 95%CI). The likelihood rose to 2.93 (2.44-4.01, 95%CI) if the pressure resulted in a right to left ventricular pressure ratio above 0.62. The patients whose figures did not exceed 49 mmHg experienced no significant residual obstruction, regardless of the pressure ratio.Conclusion: Intraoperative measurement of the right ventricular pressure can predict residual pulmonary stenosis after tetralogy repair with a reassuring cutoff of 49 mmHg
The Analgesic Effect of Transcutaneous Electrical Nerve Stimulation (TENS) on the Opposite Side for Phantom Limb Pain
Authors: Vathakul Janravee , Kessava Nanticha , Pooliam Julaporn , Datu Madonna Damayanthie , Jitsinthunun Thanawut , Zinboonyahgoon Nantthasorn
Published: April 2022

Objective: To observe the effects of TENS on the contralateral limb and PLP reduction.Materials and Methods: This was a single center retrospective study of 20 amputee participants with phantom limb pain. The inclusion criteria were participants aged above 18, average pain of at least 4/10 on the numerical rating scale (NRS), duration of pain longer than one week and treatment with TENS on the opposite side. We recorded pain intensity before and after TENS application, response time to treatment, satisfaction, and adverse effects.Results: Of the 20 amputee participants, all patients suffered from PLP and three also suffered from residual limb pain. The average pain score before use of TENS was 4.85/10 and after was 1.15/10. The mean pain intensity score was reduced by 3.7/10 (95% CI 2.95-4.45/10) or 76.28% (95% confidence interval 63.61-89.47%). The average overall satisfaction was 81.65%, and no adverse effects from application of TENS was reported.Conclusion: The study shows that the application of TENS on the opposite side is a safe and effective treatment method for intractable pain from PLP.
The Evolution of Associating Liver Partition with Portal Vein Ligation for Staged Hepatectomy
Authors: Teranasthiarphan Voramon , Pitakteerabundit Thakerng , Wiboonkhwan Nan-ak , Thongkan Tortrakoon
Published: April 2022

Associating Liver Partition with Portal Vein Ligation for Staged Hepatectomy is a cutting-edge surgical technique for resection of hepatic malignancies that has piqued the interest of the international hepatobiliary community. Patients with insufficient future liver remnants, many of whom are considered unresectable via other methods, have the possibility of being cured with this treatment. The main issues; howbeit include, increased perioperative morbidity and mortality as well as both early and rapid disease recurrence. However, with continuous improving of patient selection, optimizing stage 2 operation times and refined operative techniques this has led to reduced morbidity and mortality rates. As for its usage, the most frequent indication is colorectal liver metastasis (CRLM); in which, the results in CRLM have shown higher resectability; however, it has a comparable complication rate to two-stage hepatectomy. Conversely, perihilar cholangiocarcinoma and hepatocellular carcinoma have terrible outcomes; although, with technical refinement and better patient selection good outcomes are achievable. Herein, we summarized the current evidence based of the application of ALPPS in real-life practice, including the potential complications related to this procedure.
To gaze beyond the screen: appreciating the communicative function of mise en scène in online psychotherapy
Authors: Cachia Pierre
Published: April 2022

The screen allows psychotherapists to gaze into their patients' mise en scène. It provides those willing to see beyond the digital image, a tapestry through which it becomes possible to discern projection of patients' psychological life and the worlds they create and inhabit. Consideration of the online setting serves to enrich our work with patients and may compensate for the losses inherent in not meeting our patients in person. The fundamental elements of mise en scène, namely the lighting, colour, costume, props, décor, action and performance, space, position of the camera, framing, and the interaction of elements provide a framework on which we can focus analytic scrutiny and elicit valuable material for interpretation.
Inside out and outside in: exploring the interplay between social and psychic structures in the pandemic era
Authors: Eliza-Christie Andi Pilecki
Published: April 2022

The author reflects broadly on the impact of Covid and the concurrent sociopolitical climate on herself and her patients, with particular attention to the dynamic interplay between social and psychic structures. She presents three individual analytic treatments which demonstrate the indelible impact of family history, the internal parental couple, attachment style, object relationships, and cultural introjects on couple, relational, and social experiences in the pandemic era.
Flashy male Jamaican anoles Anolis grahami show accelerated telomere attrition
Authors: Passos Luiza
Published: April 2022

Secondary sexual traits have evolved through sexual selection, many species have developed signals that can indicate their level of other fitness-relevant traits such as fight ability. Previous studies have shown that male sexual signals are honest signals about quality in an intrasexual context, demonstrating a direct relationship between the signal’s design and the fighting ability of its possessor. However, signals can be costly since conspicuous signals are more likely to attract predators or be energetically expensive. Here we have analysed if dewlap size and colouration were reliable signs of a male’s bite force, and the physiological costs associated with larger dewlaps and intense colouration in Jamaican anoles (Anolis grahami). We analysed dewlap size and colouration against bite force, and telomere attrition. Our results supported the hypothesis that dewlap size and colour intensity are honest predictors of an individual’s fighting potential as indicated by bite force. However, we have also found a relationship between colour intensity with higher telomere attrition rates, thereby indicating a possible cost of this trait for the individual.
Embryonic morphology in two species of the Physalaemus signifer clade (Anura: Leptodactylidae)
Authors: Oliveira Marianna
Published: April 2022

We studied the embryonic morphology of Physalaemus camacan and P. signifer, two small foam-nesting frogs endemic to the Atlantic Forest. We analysed the development of transient embryonic structures and of the larval oral disc. These embryos have features typical of most congeneric species, such as the kyphotic dorsal curvature, three pairs of gills and the configuration of hatching and adhesive glands. Main differences regarding embryos of the P. cuvieri clade are the larger size and yolk provision at tailbud stage, less developed external gills and an apparently novel pattern of oral marginal papilla ontogeny. While some shifts could be correlated with variant modes of oviposition, others appear to be developmental modifications not related with ecomorphological aspects.
Awrapper algorithm improve data transfer and synchornization performance of RSYNC
Authors: Ghobadi Alireza , Eswaran C. , Ho C.K. , Lee Kee Yong , Wei Li Kok
Published: April 2022

Data transfer involving large files between two geographically distributed distant points and the problem of synchronization in a distributed environment still remain as challenging tasks. The synchronization problem exists in several data transfer applications such as web caching network, data mirroring on the web, network storage, searching engine on the web, and some online data mining systems. In this paper, a wrapper algorithm is proposed to improve the performance of the well-known RSYNC algorithm for data transfer and to improve the synchronization of deep hierarchical folders on a wide area network. The proposed algorithm can be used not only for RSYNC but also for other applications involving data transfer and synchronization. The experimental results show that the proposed framework and techniques achieve significant improvements over RSYNC with regard to data transfer speed and synchronization time.
RECORDS OF SONGS BY SUNDARAR IN PERIYAPURANAM [PERIYAPURĀṆATTIL CUNTARAR PĀṬIYA PATIKAṄKAḶIṈ PATIVUKAḶ]
Authors: A.VIJAYALACHUMI
Published: April 2022

In A.C. seventh century year, Sundarar was born in saivar kulam.Among, various saivargal tamil vedham pannirthirumuraigalul sundarar wrote “Seventh Thirumurai”.Siva peruman in his own vedham viritha thiruvayil “Thillaival Anthanartham Adiyarkum Adiyen” which gives a step by step sivanadiyargal history in detail; “Alavatra anbin perumaiyum” being one Thiruthondathogai as thirupattu was sang and given; Many perungapiyam ellakangal having in that periyapuranthin first book sundaramoorthi swamigalin thiruthonda thoigaiyagum.By gods grace he had singing tendancy, he got married with two religion women, One is being in Kanigarkulam and the other one is being in Vellalarkulam. Being his history does not make us religion separation between the surroundings; and a normal man he was adopted by religion feudatory along with Cheraman Perumal in his eighteen years old he went to kailaiyukum and being more devoted to Lord Siva; Tamil persons were more penance in thiruthondathogai tamil book tells good world has got by Sekkailar, and “Mathavam Seitha Thenthisai Valinthida” words tell the periyapuranam song. Sundarar has collected and give the history for Sekkailar, and he has been written his kapiyam by with the help of sundarar. Here, in periyapuranam we know about sundarar life in his scriptures.
Publication Trends in Surgical Treatment of Distal Radius Giant Cell Tumors Over the Past Five Years
Authors: Idulhaq Mujaddid , Utomo Pamudji , Adriansyah Denny
Published: April 2022

Background: Surgical interventions such as intralesional curettage until the complete excision and reconstruction require distal radius GCT treatment. However, to maintain the wrist function and reduce recurrent tendency, a more comprehensive understanding is needed to decide on the best therapeutic option as the standard strategy to achieve complete resection and functional outcomes. Therefore, this study aims to find the current treatment trends based on a literature study on distal radius GCT, emphasizing their potential outcomes. Methods: The search strategy using the PubMed search engine (https://pubmed.ncbi.nlm.nih. gov/) was conducted on September 21, 2020, with the keywords: “distal radius giant cell tumor”. The search resulted in 261 articles, and they were filtered by “published in the last five years,” which yielded 67 articles. These articles then underwent further screening, resulting in 40 articles for the analysis. Results: For article types, there were 27% (11/40) prospective studies, 32% (13/40) retrospective studies, 5% (2/40) systematic reviews, 27% (11/40) case reports, and 5% (2/40) case series. For the case series, more than ten cases were reported in both articles. There were 47 treatments in those total articles, and there were two types of GCT excision: intralesional curettage (extended and non-extended) (74.4%; 35/47) and en bloc (wide) resection (25.5%; 12/47). Conclusions: The total number of articles published in the last five years on the distal radius increased in 2020. Most types of articles were retrospective studies, followed by case reports and prospective studies. The most common treatment published in the last five years is intralesional curettage than en bloc resection, with excellent results in intralesional curettage’s functional outcome.
Enriquecimento proteico de resíduos de frutas tropicais por cultivo semissólido
Authors: Lima Janaina Maria de , Silva Osvaldo Soares da , Porto Lívia Dantas , Oliveira Lidiane Fernandes Barbosa de , Figueiredo Caio Franklin Vieira de , Sousa Severina de
Published: April 2022

Uma maneira eficaz de gerenciar adequadamente os resíduos agroindustriais oriundos do processamento de frutas é por meio de sua biotransformação em produtos de alto valor agregado. A fermentação, por exemplo, é uma tecnologia que se mostra eficiente na conversão de substratos com alto conteúdo de lignina e baixa quantidade de proteínas, tais como resíduos de origem vegetal, em materiais proteicamente enriquecidos. Desse modo, objetivou-se avaliar o processo de enriquecimento proteico do resíduo de abacaxi, através de fermentação semissólida, com a utilização da levedura Saccharomyces cerevisiae. O resíduo foi triturado, fermentado com 9% de inóculo e submetido a análises granulométrica e físico-químicas (teor de água, proteína bruta e sólidos solúveis totais). O resultado da granulometria demonstrou que o tamanho das partículas seguiu uma distribuição normal, com diâmetro médio de 1,31 mm. Verificou-se que houve declínio nos teores de água e sólidos solúveis totais do resíduo, enquanto o seu teor proteico foi favorecido, aumentando em relação ao tempo de fermentação. Os dados experimentais obtidos nesse estudo evidenciaram que a ação das leveduras agiu de forma benéfica sobre o resíduo, melhorando o seu valor nutricional e, portanto, viabilizando o seu uso na indústria de alimentos como matéria-prima de misturas para o suprimento proteico.
Uso de imagens infravermelhas em tendinopatia calcânea traumática
Authors: Silva Juliana Nobre da , Lopes-Martins Rodrigo Álvaro Brandão , Martini Silvia Cristina , Boschi Silvia Regina Matos da Silva , Silva Alessandro Pereira da , Scardovelli Terigi Augusto
Published: April 2022

A tendinopatia de tendão calcâneo é uma doença que acomete cerca de 10% da população mundial. Imagens de ultrassonografia e ressonância magnética podem ser utilizadas como ferramentas de auxílio ao diagnóstico, contudo, tanto a ultrassonografia, como a ressonância magnética, apresentam alta incidência de achados falso-positivos. Dessa forma, a avaliação do perfil térmico de tendões calcâneos traumaticamente lesionados, pode ser uma aliada ao diagnóstico de tendinopatia calcânea, auxiliando na diferenciação entre esta e outras patologias articulares. Sendo assim, o objetivo deste estudo foi avaliar a alteração de temperatura em tendões calcâneos de ratos após lesão traumática e verificar um padrão térmico do membro lesionado. Para tanto foram utilizados cinco ratos Wistar, cujos tendões calcâneos das patas direitas foram lesionados e as patas contralaterais foram utilizadas como controles. Através de imagens infravermelhas o perfil térmico de ambos os tendões dos ratos foi analisado, antes e após a lesão. Em ambas as patas, houve uma tendência de diminuição de temperatura tanto na pata sadia, quanto na pata lesionada e o coeficiente de determinação foi superior a 94% entre a temperatura e o intervalo de tempo. As patas lesionadas apresentaram temperatura discretamente mais elevada do que as patas não lesionadas a partir da segunda hora após a lesão. O perfil térmico estabelecido pode ser comparado com termogramas de outras patologias articulares e assim distinguir o diagnóstico entre elas. Os achados deste estudo corroboraram com achados anteriores, que demonstram que a termografia pode ser útil no diagnóstico de tendinopatia calcânea.
Dispositivos musicais na reabilitação neurológica no membro superior: uma revisão integrativa
Authors: Moniz Yasmim Fernandes , Silva Alessandro Pereira da , Gunji Bruno Toshio Gomes , Scardovelli Terigi Augusto , Martini Silvia Cristina , Boschi Silvia Regina Matos da Silva
Published: April 2022

Introdução: A reabilitação neurológica do membro superior é um processo desafiador que exige alta adesão do paciente para resultados efetivos. Uma das estratégias para promover a neuroplastidade e a motivação dos pacientes é a utilização de música na reabilitação. Os progressos nesta área motivaram a criação de dispositivos/jogos musicais que visam a reabilitação de forma lúdica, funcional e menos fatigante. Objetivos: Sintetizar e analisar por meio de uma revisão integrativa os benefícios, usabilidade, limitações e possíveis aprimoramentos dos dispositivos musicais aplicados a reabilitação neurológica. Metodologia:  A busca dos artigos foi realizada nas bases de dados PubMed, Scielo, PeDro e Cochrane Library. Utilizou-se os seguintes descritores: “Music Intervention”, “Rehabilitation”, “Music Device”, “Neurologic Disease”, “Upper Limb”, associados aos boleanos “and” e “or” sendo os descritores indicados no título ou no resumo do artigo. Foram admitidos artigos publicados nos últimos 10 anos e sem restrição de idioma. Resultados: Foram encontrados 5 artigos que satisfaziam os critérios de inclusão. Os dispositivos foram desenvolvidos para pacientes com Acidente Vascular Encefálico e Doença de Parkinson. Os principais benefícios foram: aumento da repetição das tarefas, melhora nas habilidades rítmicas, aumento coerência da fase cortiço muscular, aumento da motivação do voluntário e melhora na suavidade dos movimentos. Conclusão: A utilização de dispositivos musicais na reabilitação neurológica do membro superior se mostrou benéfica, viável e sem riscos aparentes. Ainda há um número escasso de artigos, principalmente ensaios clínicos randomizados, além de amostras não tão representativas, são necessários mais estudos para validar a utilização destes dispositivos.
A Teoria do Empreendedorismo pelo Transbordamento de Conhecimento: debates atuais e direções para pesquisas futuras sobre ecossistemas empreendedores e inovadores
Authors: Santos Isabel Cristina dos , Farina Milton Carlos , Frazão Camila do Nascimento Ferreira , Sousa Francicleide Gonçalves de , Fontes Nadja Marques de
Published: April 2022

A emergência da economia do conhecimento desperta a relevância de identificar elementos que possam favorecer a superação de barreiras relacionadas à capacidade das regiões em gerar e difundir o conhecimento comercialmente relevante. O objetivo deste artigo é examinar como a literatura utiliza a Teoria do Empreendedorismo pelo Transbordamento de Conhecimento (KSTE) para discutir o enlace entre conhecimento tecnológico e o empreendedorismo de base tecnológica. A KSTE foi formulada nos últimos 10 anos, e desde então, a sua difusão tem se dado entre pesquisadores da comunidade científica mundial e está presente em diversos campos de pesquisa. Os resultados indicam que a KSTE vem sendo adotada como um fundamento que explica a relação entre dois fenômenos, empreendedorismo tecnológico e conhecimento, especialmente, a partir dos trabalhos publicados de 2013 em diante. Observa-se ainda que as pesquisas neste campo têm crescido rapidamente, associando-as aos ecossistemas empreendedores e inovadores. Este estudo tem relevância acadêmica e inova ao identificar os principais temas da literatura a luz da Teoria do Empreendedorismo pelo Transbordamento de Conhecimento, complementando pesquisas anteriores na área e indicando nova direção de pesquisa.
Avaliação e fatores associados à qualidade do sono de acadêmicos de medicina do município de Rio Verde – Goiás
Authors: Silva Renato Canevari Dutra da , Oliveira André Vinícius de , Garbelini Giulia Ugucioni , Júdice Marcelo Gomes , Arantes Ana Paula Felix , Guerra Heloísa Silva , Moreira Berenice , Camargo Júnior Elton Brás
Published: April 2022

Objetivo: Avaliar a qualidade do sono em acadêmicos de medicina, além de demonstrar os fatores associados. Métodos: Estudo transversal realizado em estudantes do quinto e sexto ano da faculdade de medicina, através da aplicação do Índice da Qualidade do Sono de Pittsburgh (PSQI) e os resultados analisados pelo programa Statistical Package for Social Science (SPSS) para se estabelecer correlações entre a qualidade do sono e as variáveis independentes analisadas, através do teste do Qui-Quadrado de Pearson. Resultados: a prevalência de má qualidade do sono foi de 63,6%. Constatou-se que a baixa qualidade do sono foi associada ao sexo feminino, falhas de memória e privação do sono. Conclusão: A maioria do acadêmicos apresentou qualidade de sono ruim, o que pode estar afetando significativamente sua saúde e o desempenho educacional, evidenciando a importância de medidas educativas relacionadas à higiene e rotina de sono para esta população.
Tempo de vida dos sistemas CCl4 com Gn (Gn= He, Ne e Ar), O2, D2O e ND3
Authors: Paula Maria Elane Aquino dos Santos , Moura Francisco Antonio Gudemberg Almeida , Oliveira Rhuiago Mendes de
Published: April 2022

As propriedades de sistemas envolvendo gases nobres têm auxiliado muito no desenvolvimento de técnicas de modelagem e de valores padrão para estudos experimentais. O objetivo desse trabalho foi calcular o tempo de vida dos sistemas moleculares formados pelo hélio, neônio, argônio, dioxigênio, água deuterada, amônia deuterada e o tetracloreto de carbono (He - CCl4, Ne - CCl4, Ar - CCl4, O2 - CCl4, D2O - CCl4 e ND3 - CCl4). Para tanto, usou-se a teoria de Slater que consiste em uma formulação puramente dinâmica, com uma análise vibracional completa dos complexos. O primeiro nível de energia rovibracional (E0,0) e a frequência de vibração (ωe) utilizadas, foram obtidas via método da Representação da variável discreta e Dunham, respectivamente. Os resultados obtidos tanto pela forma analítica Lennard-Jones (LJ) quanto com a Improved Lennard-Jones (ILJ), mostram que todos os sistemas são estáveis e que o tempo de vida calculado a partir da ILJ é sempre menor quando comparado com o tempo de vida fornecido a partir da LJ. Os resultados do presente artigo, auxiliarão na compreensão de sistemas envolvendo os gases nobres, assim como na compreensão das complicadas interações entre a água e moléculas de interesse biológico.
Parenting Styles and Academic Achievement among Malaysian Students: Mediating Role of Parental Involvement
Authors: Mian Mian Seet  , Rabbani Mohtaram , Hosseinian Simin , Ravindran Latha  , Rajan Mohan Shanthi Bavani V
Published: April 2022

The goal of the study is to see how parental participation affects the relationship between parenting styles and academic success in Malaysian primary school students. A quantitative technique was applied in this investigation. Private tuition centres in an urban area were used to recruit students. The information gathered for this investigation was numerically assessed and interpreted. Families are divided into four groups by the Parenting Style Index: authoritative, authoritarian, permissive, and indulgent. The relationship between parenting styles and academic success was studied using Pearson's correlation coefficient matrix. It was discovered that it completely mediates the relationship between authoritative and authoritarian parenting styles and student academic attainment. The study's findings show that understanding and receiving knowledge about how parenting styles and parental involvement affect children's academic achievement is crucial for parents.
Brainwaves Activities during Resting State: A Neurofeedback Case Study
Authors: Mohd Radi Nur Afiqah , Nasaruddin Nurul Hanim
Published: April 2022

Neurofeedback training (NFT) on a healthy participant was used to analyse brainwave activity during resting state. Electrodes were placed on the prefrontal cortex and at reference sites to conduct the experiment. The patient was asked to remain still and rest by sitting in a chair. The technology was then used to record the electrical waves emitted by brain activities. After ten cycles with a break interval, theta, alpha, and high beta brainwaves were discovered. There were statistically significant brainwaves in the prefrontal cortex. Remarkably, the ascending high beta oscillation range was the highest, while the alpha wave was the lowest, contradicting earlier results. Anxiety, excitement, and focus were thought to be associated with the highest range of high beta waves.
Pengaruh Perlakuan Permukaan Pengikatan Terhadap Sifat Mekanik Komposit Serat Kaca Dengan Laminasi Almunium
Authors: Fakhruddin Muhammad , Maskuri Maskuri , Faizal Elka , Pranoto Bayu , Wicaksono Hangga , Firmansyah Hilmi Iman
Published: April 2022

Fiber metal laminates or commonly known as fiber metal laminates (FML) are composite structures made by combining 2 layers of material as the outer layer with the core material. The outer layer of this composite is called the laminate. Generally, laminated composites are produced by joining techniques under solid-state conditions, such as diffusion bonding, extrusion, friction-stir welding, and roller welding. In this study, glass fiber composites with aluminum lamination were made using the vacuum assisted resin infusion (VARI) method, using epoxy resin. The surface treatment of the aluminum laminate was carried out with the direction of roughing at certain angles and variations of the surface roughening of the laminate to test the mechanical bonding between the composite and the laminate. Mechanical bonding testing using three-point bending test method (three-point bending) and buckling test. The expected result is that by surface treatment on aluminum laminate, the best mechanical bonding to composites with glass fiber is obtained. The TKT to be achieved from this research is TKT level 3, which is an analytical study that supports the prediction of the performance of the effect of the bonding surface treatment on the mechanical properties of glass fiber composites with aluminum lamination.
Pro-Angiogenesis Role of LINC00662 From Esophageal Squamous Cell Carcinoma Cells-Derived Extracellular Vehicles
Authors: Li Feng , Niu Ren , Gao ShaoLin , Zhao FangChao , Dong Zefang , Zhang Hao , Li Shujun
Published: April 2022

Objective: LINC00662 is oncogenic in some human cancers, but no much was revealed concerning to its specific action in tumor angiogenesis. Given that, our study investigated the role of LINC00662 from esophageal squamous cell carcinoma (ESCC) cells-derived extracellular vehicles (EVs) in angiogenesis through microRNA (miR)-195-5p/vascular endothelial growth factor A (VEGFA) axis.

Methods: Clinical tissue samples were collected from patients with ESCC, in which LINC00662, miR-195-5p and VEGFA expression was analyzed. ESCC cells were transfected, from which EVs were isolated. Human umbilical vein endothelial cells (HUVECs) were co-cultured with the pretreated EVs. After that, viability, colony formation ability, invasion, migration and tube formation ability of HUVECs were observed. Tumor xenograft in nude mice was performed to detect the effect of LINC00662, miR-195-5p or EV specific inhibitor GW4869 on tumor development.

Results: LINC00662 and VEGFA were upregulated while miR-195-5p was downregulated in the cancer tissue of patients with ESCC. EVs derived from ESCC cells promoted viability, colony formation ability, invasion and tube formation ability of HUVECs. Downregulation of LINC00662 or upregulation of miR-195-5p reversed the promotion of EVs derived from ESCC cells on the viability, colony formation ability, invasion and tube formation ability of HUVECs in vitro and in vivo. VEGFA overexpression reversed EVs carrying restored miR-195-5p induced effects on HUVECs in vitro.

Conclusion: In summary, elevated LINC00662 transferred by ESCC cells-derived EVs induces angiogenesis through downregulating miR-195-5p and upregulating VEGFA.
3D-Printed Hydrogels in Orthopedics: Developments, Limitations, and Perspectives
Authors: Liu Zhen , Xin Weiwei , Ji Jindou , Xu Jialian , Zheng Liangjun , Qu Xinhua , Yue Bing
Published: April 2022

Three-dimensional (3D) printing has been used in medical research and practice for several years. Various aspects can affect the finished product of 3D printing, and it has been observed that the impact of the raw materials used for 3D printing is unique. Currently, hydrogels, including various natural and synthetic materials, are the most biologically and physically advantageous biological raw materials, and their use in orthopedics has increased considerably in recent years. 3D-printed hydrogels can be used in the construction of extracellular matrix during 3D printing processes. In addition to providing sufficient space structure for osteogenesis and chondrogenesis, hydrogels have shown positive effects on osteogenic and chondrogenic signaling pathways, promoting tissue repair in various dimensions. 3D-printed hydrogels are currently attracting extensive attention for the treatment of bone and joint injuries owing to the above-mentioned significant advantages. Furthermore, hydrogels have been recently used in infection prevention because of their antiseptic impact during the perioperative period. However, there are a few shortcomings associated with hydrogels including difficulty in getting rid of the constraints of the frame, poor mechanical strength, and burst release of loadings. These drawbacks could be overcome by combining 3D printing technology and novel hydrogel material through a multi-disciplinary approach. In this review, we provide a brief description and summary of the unique advantages of 3D printing technology in the field of orthopedics. In addition, some 3D printable hydrogels possessing prominent features, along with the key scope for their applications in bone joint repair, reconstruction, and antibacterial performance, are discussed to highlight the considerable prospects of hydrogels in the field of orthopedics.
Hydrogel Encapsulation: Taking the Therapy of Mesenchymal Stem Cells and Their Derived Secretome to the Next Level
Authors: Huang Yuling , Li Xin , Yang Lina
Published: April 2022

Biomaterials have long been the focus of research and hydrogels are representatives thereof. Hydrogels have attracted much attention in the medical sciences, especially as a candidate drug-carrier. Mesenchymal stem cells (MSC) and MSC-derived secretome are a promising therapeutic method, owing to the intrinsic therapeutic properties thereof. The low cell retention and poor survival rate of MSCs make further research difficult, which is a problem that hydrogel encapsulation largely solved. In this review, safety and feasibility of hydrogel-encapsulated MSCs, the improvement of the survival, retention, and targeting, and the enhancement of their therapeutic effect by hydrogels were studied. The status of the hydrogel-encapsulated MSC secretome was also discussed.
Can Manganese Dioxide Microspheres be Used as Intermediaries to Alleviate Intervertebral Disc Degeneration With Strengthening Drugs?
Authors: Zhang Wentao , Yang Ming , Sun Tianze , Zhang Jing , Zhao Yantao , Li Jingmin , Li Zhonghai
Published: April 2022

Degenerative disc disease (DDD) is a pathological condition associated with intervertebral discs (IVDs) that causes chronic back pain. IVD degeneration has become a significant issue in contemporary society. To date, numerous biological therapies have been applied to alleviate the progression of DDD, among which therapeutic protein injection is the most direct and convenient. However, there are some limitations to applying direct protein injection therapy, the most significant being that the efficacy of this method has a short duration, which is a major factor in its effectiveness and the resulting patient satisfaction. How do we solve this problem? Or how can the effectiveness of the treatment be enhanced? It has been proved that manganese dioxide (MnO2) microspheres, widely used in environmental science, not only regulate the expression of cell genes and cytokines in the microenvironment, but also have the ability to release drugs slowly. We propose that direct injection of protein encapsulated in hollow MnO2 (h-MnO2) microspheres could solve the problem of rapid drug release. In addition, the use of a MnO2 and protein injection in the treatment of DDD may have a synergistic effect, which would be highly significant for the degradation of pro-inflammatory factors in the DDD microenvironment. Therefore, the combination of MnO2 and protein may provide a new therapeutic approach to alleviate the progression of DDD.
Oral Elesclomol Treatment Alleviates Copper Deficiency in Animal Models
Authors: Yuan Sai , Korolnek Tamara , Kim Byung-Eun
Published: April 2022

Copper (Cu) is an essential trace element for key biochemical reactions. Dietary or genetic copper deficiencies are associated with anemia, cardiomyopathy, and neurodegeneration. The essential requirement for copper in humans is illustrated by Menkes disease, a fatal neurodegenerative disorder of early childhood caused by mutations in the ATP7A copper transporter. Recent groundbreaking studies have demonstrated that a copper delivery small molecule compound, elesclomol (ES), is able to substantially ameliorate pathology and lethality in a mouse model of Menkes disease when injected as an ES-Cu2+ complex. It is well appreciated that drugs administered through oral means are more convenient with better efficacy than injection methods. Here we show, using genetic models of copper-deficient C. elegans and mice, that dietary ES supplementation fully rescues copper deficiency phenotypes. Worms lacking either the homolog of the CTR1 copper importer or the ATP7 copper exporter showed normal development when fed ES. Oral gavage with ES rescued intestine-specific Ctr1 knockout mice from early postnatal lethality without additional copper supplementation. Our findings reveal that ES facilitates copper delivery from dietary sources independent of the intestinal copper transporter CTR1 and provide insight into oral administration of ES as an optimal therapeutic for Menkes disease and possibly other disorders of copper insufficiency.