bluuebunny/crossref_metadata_2025 huggingface dataset:
Up to 50 Gb/s modulation of an EAM integrated widely tunable DBR laser
Authors: Liu Yunlong , Zhang Lichen , La Xiaobo , Zhu Xuyuan , Zhao Lingjuan , Wang Wei , Liang Song
Published: January 2021

An electro-absorption modulator (EAM) integrated widely tunable distributed Bragg reflector (DBR) laser working at 1.5 µm is reported. By utilizing the RF resonance between the bonding wire and the EAM, a 28 GHz modulation bandwidth is obtained. The device is modulated with up to 50 Gb/s NRZ data. At 28 Gb/s, the power penalty to obtain a 10−10 bit error rate (BER) after a 5 Km standard single mode fiber transmission is less than 0.7 dB. Because the DBR material has a long bandgap wavelength, the wavelength tuning range of the laser is larger than 12 nm. The DBR laser is a promising low cost tunable light source for future high capacity wavelength division multiplexing (WDM) optical communication systems.
Fluorescence lifetime imaging via spatio-temporal speckle patterns in a single-pixel camera configuration
Authors: Junek J. , Žídek K.
Published: January 2021

Photoluminescence (PL) spectroscopy offers excellent methods for mapping the PL decay on the nanosecond time scale. However, capturing maps of emission dynamics on the microsecond timescale can be highly time-consuming. We present a new approach to fluorescence lifetime imaging (FLIM), which combines the concept of random temporal speckles excitation (RATS) with the concept of a single-pixel camera based on spatial speckles. The spatio-temporal speckle pattern makes it possible to map PL dynamics with unmatched simplicity. Moreover, the method can acquire all the data necessary to map PL decay on the microsecond timescale within minutes. We present proof-of-principle measurements for two samples and compare the reconstructed decays to the non-imaging measurements. Finally, we discuss the effect of the preprocessing routine and other factors on the reconstruction noise level. The presented method is suitable for lifetime imaging processes in several samples, including monitoring charge carrier dynamics in perovskites or monitoring solid-state luminophores with a long lifetime of PL.
Ultrafast photophysical process of bi-exciton Auger recombination in CuInS2 quantum dots studied by transient-absorption spectroscopy
Authors: Yang Gaoyuan , Shi Shuang , Zhang Xin , Zhou Shuxing , Liu Dezheng , Liang Ying , Chen Zongwei , Liang Guijie
Published: January 2021

Auger recombination is an ultrafast and unnegligible photophysical process in colloidal semiconductor quantum dots (QDs) due to competition with charge separation or radiative recombination processes, pivotal for their applications ranging from bio-labeling, light-emitting diodes, QD lasing to solar energy conversion. Among diverse QDs, ternary chalcopyrite is recently receiving significant attention for its heavy-metal free property and remarkable optical performance. Given deficient understanding of the Auger process for ternary chalcopyrite QDs, CuInS2 QDs with various sizes are synthesized as a representative and the bi-exciton lifetime (τBX) is derived by virtue of ultrafast time resolved absorption spectrum. The trend of τBX varying with size is consistent with the universal scaling of τBX versus QD volume (V): τBX = γV. The scaling factor γ is 6.6 ± 0.5 ps·nm−3 for CuInS2 QDs, and the bi-exciton Auger lifetime is 4–5 times slower than typical CdSe QDs with the same volume, suggesting reduced Auger recombination rate in ternary chalcopyrite. This work facilitates clearer understanding of Auger process and provides further insight for rational design of light-harvesting and emitting devices based on ternary chalcopyrite QDs.
Copper circuits fabricated on flexible polymer substrates by a high repetition rate femtosecond laser-induced selective local reduction of copper oxide nanoparticles
Authors: Huang Yajun , Xie Xiaozhu , Li Miaoni , Xu Meifang , Long Jiangyou
Published: January 2021

In this work, copper circuits were fabricated on flexible polyimide (PI) substrates by high repetition rate femtosecond laser-induced selective local reduction of copper oxide nanoparticles (CuO NPs). The effects of laser pulse energy and laser scanning velocity on the quality of the copper circuit were studied. By optimizing laser processing parameters, we prepared a Cu circuit of a line width of 5.5 µm and an electrical resistivity of 130.9 µΩ·cm. The Cu/O atomic ratio of the Cu circuit reaches ∼10.6 and the proportion of Cu is 91.42%. We then studied the formation mechanism of the copper circuit by simulating the temperature field under the irradiation of high repetition rate femtosecond laser pulses. The results show that the thermochemical reduction reaction induced by the high repetition rate femtosecond laser reduces CuO NPs into Cu NPs. Under the thermal effect of the high repetition rate femtosecond laser, Cu NPs agglomerate and grow to form a uniform and continuous Cu circuit.
Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference
Authors: Best Katharine , Barouch Dan H. , Guedj Jeremie , Ribeiro Ruy M. , Perelson Alan S.
Published: January 2021

Experimental Zika virus infection in non-human primates results in acute viral load dynamics that can be well-described by mathematical models. The inoculum dose that would be received in a natural infection setting is likely lower than the experimental infections and how this difference affects the viral dynamics and immune response is unclear. Here we study a dataset of experimental infection of non-human primates with a range of doses of Zika virus. We develop new models of infection incorporating both an innate immune response and viral interference with that response. We find that such a model explains the data better than models with no interaction between virus and the immune response. We also find that larger inoculum doses lead to faster dynamics of infection, but approximately the same total amount of viral production.
Estimating and interpreting secondary attack risk: Binomial considered biased
Authors: Sharker Yushuf , Kenah Eben
Published: January 2021

The household secondary attack risk (SAR), often called the secondary attack rate or secondary infection risk, is the probability of infectious contact from an infectious household memberAto a given household memberB, where we define infectious contact to be a contact sufficient to infectBif he or she is susceptible. Estimation of the SAR is an important part of understanding and controlling the transmission of infectious diseases. In practice, it is most often estimated using binomial models such as logistic regression, which implicitly attribute all secondary infections in a household to the primary case. In the simplest case, the number of secondary infections in a household withmsusceptibles and a single primary case is modeled as a binomial(m,p) random variable wherepis the SAR. Although it has long been understood that transmission within households is not binomial, it is thought that multiple generations of transmission can be neglected safely whenpis small. We use probability generating functions and simulations to show that this is a mistake. The proportion of susceptible household members infected can be substantially larger than the SAR even whenpis small. As a result, binomial estimates of the SAR are biased upward and their confidence intervals have poor coverage probabilities even if adjusted for clustering. Accurate point and interval estimates of the SAR can be obtained using longitudinal chain binomial models or pairwise survival analysis, which account for multiple generations of transmission within households, the ongoing risk of infection from outside the household, and incomplete follow-up. We illustrate the practical implications of these results in an analysis of household surveillance data collected by the Los Angeles County Department of Public Health during the 2009 influenza A (H1N1) pandemic.
High global consumption of potentially inappropriate fixed dose combination antibiotics: Analysis of data from 75 countries
Authors: Bortone Barbara , Jackson Charlotte , Hsia Yingfen , Bielicki Julia , Magrini Nicola , Sharland Mike
Published: January 2021

Antibiotic fixed dose combinations (FDCs) can have clinical advantages such as improving effectiveness and adherence to therapy. However, high use of potentially inappropriate FDCs has been reported, with implications for antimicrobial resistance (AMR) and toxicity. We used a pharmaceutical database, IQVIA-Multinational Integrated Data Analysis System (IQVIA-MIDAS®), to estimate sales of antibiotic FDCs from 75 countries in 2015. Antibiotic consumption was estimated using standard units (SU), defined by IQVIA as a single tablet, capsule, ampoule, vial or 5ml oral suspension. For each FDC antibiotic, the approval status was assessed by either registration with the United States Food and Drug Administration (US FDA) or inclusion on the World Health Organization (WHO) Essential Medicines List (EML). A total of 119 antibiotic FDCs were identified, contributing 16.7 x 109 SU, equalling 22% of total antibiotic consumption in 2015. The most sold antibiotic FDCs were amoxicillin-clavulanic acid followed by trimethoprim/sulfamethoxazole and ampicillin/cloxacillin. The category with the highest consumption volume was aminopenicillin/β-lactamase inhibitor +/- other agents. The majority of antibiotic FDCs (92%; 110/119) were not approved by the US FDA. Of these, the most sold were ampicillin/cloxacillin, cefixime/ofloxacin and metronidazole/spiramycin. More than 80% (98/119) of FDC antibiotics were not compatible with the 2017 WHO EML. The countries with the highest numbers of FDC antibiotics were India (80/119), China (25/119) and Vietnam (19/119). There is high consumption of FDC antibiotics globally, particularly in middle-income countries. The majority of FDC antibiotic were not approved by either US FDA or WHO EML. International initiatives such as clear guidance from the WHO EML on which FDCs are not appropriate may help to regulate the manufacturing and sales of these antibiotics.
Treatment outcomes of drug susceptible Tuberculosis in private health facilities in Lagos, South-West Nigeria
Authors: Oladimeji Olanrewaju , Adepoju Victor , Anyiam Felix Emeka , San James Emmanuel , Odugbemi Babatunde A. , Hyera Francis Leonard Mpotte , Sibiya Maureen Nokuthula , Yaya Sanni , Zoakah Ayuba Ibrahim , Lawson Lovett
Published: January 2021

Background

The Lagos State Tuberculosis, Buruli Ulcer, and Leprosy Control Program (LSTBLCP) started engaging private hospitals under the Public-Private Mix (PPM) Program in 2008. The study aimed to evaluate the trend and predictors of successful Tuberculosis (TB) treatment outcomes of patients managed across these private health facilities between 2010–2016 in Lagos, Nigeria.

Methods

Retrospective review of TB treatment register and treatment cards of patients commenced on TB treatment between January 2010 and December 2016 in 36 private health facilities engaged by the LSTBLCP. Between December 2016 and February 2017, data were collected and entered into Microsoft Excel by trained data entry clerks. The analysis was done using SPSS software. Independent predictors of successful treatment outcomes were determined using multivariate analysis at the statistical significance of p<0.05 and 95% confidence interval.

Results

A total of 1660 records of TB patients were reviewed. 1535 (92.47%) commenced treatment, while 1337 (87.10%) of all records had documented treatment outcomes. Of the 1337 patients with outcomes, 1044 (78.09%) had a successful treatment outcome, and 293 (21.91%) had an unsuccessful outcome. Majority were male, 980 (59.04%), Human Immunodeficiency Virus (HIV) negative status, 1295 (80.24%), diagnosed with smear, 1141 (73.14%), treated in private not-for-profit (PNFP) hospital, 1097 (66.08%), treated for TB between 2014–2016 (18.96%-19.52%). In multivariate analysis, age>20years (aOR = 0.26, p = 0.001), receiving TB treatment in 2013 (aOR = 0.39, p = 0.001), having genexpert for TB diagnosis (aOR = 0.26, p = 0.031) and being HIV positive (aOR = 0.37, p = 0.001) significantly reduced likelihood of successful treatment outcome. The site of TB, being on ART or CPT, were confounding determinants of successful treatment outcomes as they became non-significant at the multivariate analysis level.

Conclusion

Treatment outcome among Lagos private hospitals was low compared with NTBLCP and World Health Organization (WHO) target. We urge the government and TB stakeholders to strengthen the PPM interventions to improve adherence, particularly among People Living with HIV (PLHIV) and older TB patients. Hence, promotion of early care-seeking, improving diagnostic and case holding efficiencies of health facilities, and TB/HIV collaborative interventions can reduce the risk of an unsuccessful outcome.
How Assad changed population growth in Sweden and Norway: Syrian refugees’ impact on Nordic national and municipal demography
Authors: Tønnessen Marianne , Aradhya Siddartha , Mussino Eleonora
Published: January 2021

In an increasingly interconnected world, the demographic effects of wars are not confined only to war zones and neighbouring areas; wars and conflicts may also change populations far away. Without the war in Syria under President Assad and the associated mass exodus of Syrian refugees, the population trends in distant countries like Sweden and Norway over the last few years would have been different. We create hypothetical scenarios of the population developments in Sweden and Norway without a war in Syria from 2011 onwards, where excess immigration due to the war and associated excess births are removed. The results indicate that population growth in 2016 would have been roughly 36% lower in Sweden and 26% lower in Norway without the Syrian war. The number of births in 2017 would have been about 3% lower in Sweden and 1% lower in Norway. One in ten municipalities would have had a population decline in 2016 instead of a population increase, and the largest immigrant group in Sweden by January 2019 would still be of Finnish origin.
Finding karstic caves and rockshelters in the Inner Asian mountain corridor using predictive modelling and field survey
Authors: Cuthbertson Patrick , Ullmann Tobias , Büdel Christian , Varis Aristeidis , Namen Abay , Seltmann Reimar , Reed Denné , Taimagambetov Zhaken , Iovita Radu
Published: January 2021

The area of the Inner Asian Mountain Corridor (IAMC) follows the foothills and piedmont zones around the northern limits of Asia’s interior mountains, connecting two important areas for human evolution: the Fergana valley and the Siberian Altai. Prior research has suggested the IAMC may have provided an area of connected refugia from harsh climates during the Pleistocene. To date, this region contains very few secure, dateable Pleistocene sites, but its widely available carbonate units present an opportunity for discovering cave sites, which generally preserve longer sequences and organic remains. Here we present two models for predicting karstic cave and rockshelter features in the Kazakh portion of the IAMC. The 2018 model used a combination of lithological data and unsupervised landform classification, while the 2019 model used feature locations from the results of our 2017–2018 field surveys in a supervised classification using a minimum-distance classifier and morphometric features derived from the ASTER digital elevation model (DEM). We present the results of two seasons of survey using two iterations of the karstic cave models (2018 and 2019), and evaluate their performance during survey. In total, we identified 105 cave and rockshelter features from 2017–2019. We conclude that this model-led approach significantly reduces the target area for foot survey.
Water affordability and human right to water implications in California
Authors: Goddard Jessica J. , Ray Isha , Balazs Carolina
Published: January 2021

Water affordability is central to water access but remains a challenge to measure. California enshrined the human right to safe and affordable water in 2012 but the question remains: how should water affordability be measured across the state? This paper contributes to this question in three steps. First, we identify key dimensions of water affordability measures (including scale, volume of water needed to meet ‘basic’ needs, and affordability criteria) and a cross-cutting theme (social equity). Second, using these dimensions, we develop three affordability ratios measured at the water system scale for households with median, poverty level, and deep poverty (i.e., half the poverty level) incomes and estimate the corresponding percentage of households at these income levels. Using multiple measures conveys a fuller picture of affordability given the known limitations of specific affordability measures. Third, we analyze our results disaggregated by a key characteristic of water system vulnerability–water system size. We find that water is relatively affordable for median income households. However, we identify high unaffordability for households in poverty in a large fraction of water systems. We identify several scenarios with different policy implications for the human right to water, such as very small systems with high water bills and low-income households within large water systems. We also characterize how data gaps complicate theoretical ideals and present barriers in human right to water monitoring efforts. This paper presents a systematic approach to measuring affordability and represents the first statewide assessment of water affordability within California’s community water systems.
Identifying intentional injuries among children and adolescents based on Machine Learning
Authors: Yin Xiling , Ma Dan , Zhu Kejing , Li Deyun
Published: January 2021

Background

Compared to other studies, the injury monitoring of Chinese children and adolescents has captured a low level of intentional injuries on account of self-harm/suicide and violent attacks. Intentional injuries in children and adolescents have not been apparent from the data. It is possible that there has been a misclassification of existing intentional injuries, and there is a lack of research literature on the misclassification of intentional injuries. This study aimed to discuss the feasibility of discriminating the intention of injury based on Machine Learning (ML) modelling and provided ideas for understanding whether there was a misclassification of intentional injuries.

Methods

Information entropy was used to determine the correlation between variables and the intention of injury, and Naive Bayes (NB), Decision Tree (DT), Random Forest (RF), Adaboost algorithms and Deep Neural Networks (DNN) were used to create an intention of injury discrimination model. The models were compared by comprehensively testing the discrimination effect to determine stability and consistency.

Results

For the area under the ROC curve with different intentions of injuries, the NB model was 0.891, 0.880, and 0.897, respectively; the DT model was 0.870, 0.803, and 0.871, respectively; the RF model was 0.850, 0.809, and 0.845, respectively; the Adaboost model was 0.914, 0.846, and 0.914, respectively; the DNN model was 0.927, 0.835, and 0.934, respectively. In a comprehensive comparison of the five models, DNN and Adaboost models had higher values for the determination of the intention of injury. A discrimination of cases with unclear intentions of injury showed that on average, unintentional injuries, violent attacks, and self-harm/suicides accounted for 86.57%, 6.81%, and 6.62%, respectively.

Conclusion

It was feasible to use the ML algorithm to determine the injury intention of children and adolescents. The research suggested that the DNN and Adaboost models had higher values for the determination of the intention of injury. This study could build a foundation for transforming the model into a tool for rapid diagnosis and excavating potential intentional injuries of children and adolescents by widely collecting the influencing factors, extracting the influence variables characteristically, reducing the complexity and improving the performance of the models in the future.
Pay for performance, satisfaction and retention in longitudinal crowdsourced research
Authors: Auer Elena M. , Behrend Tara S. , Collmus Andrew B. , Landers Richard N. , Miles Ahleah F.
Published: January 2021

In the social and cognitive sciences, crowdsourcing provides up to half of all research participants. Despite this popularity, researchers typically do not conceptualize participants accurately, as gig-economy worker-participants. Applying theories of employee motivation and the psychological contract between employees and employers, we hypothesized that pay and pay raises would drive worker-participant satisfaction, performance, and retention in a longitudinal study. In an experiment hiring 359 Amazon Mechanical Turk Workers, we found that initial pay, relative increase of pay over time, and overall pay did not have substantial influence on subsequent performance. However, pay significantly predicted participants' perceived choice, justice perceptions, and attrition. Given this, we conclude that worker-participants are particularly vulnerable to exploitation, having relatively low power to negotiate pay. Results of this study suggest that researchers wishing to crowdsource research participants using MTurk might not face practical dangers such as decreased performance as a result of lower pay, but they must recognize an ethical obligation to treat Workers fairly.
Effects of electrotactic exercise and antioxidant EUK-134 on oxidative stress relief in Caenorhabditis elegans
Authors: Pham Thi Thanh Huong , Huang Wan-Ying , Chen Chang-Shi , Chiu Wen-Tai , Chuang Han-Sheng
Published: January 2021

Antioxidant uptake and regular exercise are two well-acknowledged measures used for rejuvenation and oxidative stress elimination. Previous studies have revealed that moderate exercise mildly increases intracellular signaling oxidant levels and strengthens the ability of an organism to deal with escalating oxidative stress by upregulating antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase. Antioxidant supplementation directly scavenges intracellular reactive oxygen species (ROS) to reduce oxidative stress. However, research to understand the impacts of these enzymes on mitigating oxidative stress from the perspective of simple animals is limited. Herein, we show that exercise combined with antioxidant supplementation ameliorates the physiological phenotypes and markers of aging in wild-type and SOD/CAT-deficient Caenorhabditis elegans. We discovered that treated wild-type and gene-deficient worms show better survivorship, reproduction, and motility compared with their control counterparts. Assays of biochemical indices revealed that variations in sod-3 expression under different stress levels imply an inducible enzyme response resulting from exercise training and antioxidant supplementation. In addition, induced ROS resistance obtained from any type of treatment could persist for several days even after treatment cessation, thus suggesting a potential long-term antioxidative stress effect. Our findings confirm that exercise, antioxidant supplementation, and their combination could significantly improve the ability of C. elegans to withstand adverse stress. Our observations provide promising insights into future therapies of anti-oxidative stress in higher animals.
One-time-pad cipher algorithm based on confusion mapping and DNA storage technology
Authors: Peng Weiping , Cui Shuang , Song Cheng
Published: January 2021

In order to solve the problems of low computational security in the encoding mapping and difficulty in practical operation of biological experiments in DNA-based one-time-pad cryptography, we proposed a one-time-pad cipher algorithm based on confusion mapping and DNA storage technology. In our constructed algorithm, the confusion mapping methods such as chaos map, encoding mapping, confusion encoding table and simulating biological operation process are used to increase the key space. Among them, the encoding mapping and the confusion encoding table provide the realization conditions for the transition of data and biological information. By selecting security parameters and confounding parameters, the algorithm realizes a more random dynamic encryption and decryption process than similar algorithms. In addition, the use of DNA storage technologies including DNA synthesis and high-throughput sequencing ensures a viable biological encryption process. Theoretical analysis and simulation experiments show that the algorithm provides both mathematical and biological security, which not only has the difficult advantage of cracking DNA biological experiments, but also provides relatively high computational security.
A workflow for sizing oligomeric biomolecules based on cryo single molecule localization microscopy
Authors: Schneider Magdalena C. , Telschow Roger , Mercier Gwenael , López-Martinez Montserrat , Scherzer Otmar , Schütz Gerhard J.
Published: January 2021

Single molecule localization microscopy (SMLM) has enormous potential for resolving subcellular structures below the diffraction limit of light microscopy: Localization precision in the low digit nanometer regime has been shown to be achievable. In order to record localization microscopy data, however, sample fixation is inevitable to prevent molecular motion during the rather long recording times of minutes up to hours. Eventually, it turns out that preservation of the sample’s ultrastructure during fixation becomes the limiting factor. We propose here a workflow for data analysis, which is based on SMLM performed at cryogenic temperatures. Since molecular dipoles of the fluorophores are fixed at low temperatures, such an approach offers the possibility to use the orientation of the dipole as an additional information for image analysis. In particular, assignment of localizations to individual dye molecules becomes possible with high reliability. We quantitatively characterized the new approach based on the analysis of simulated oligomeric structures. Side lengths can be determined with a relative error of less than 1% for tetramers with a nominal side length of 5 nm, even if the assumed localization precision for single molecules is more than 2 nm.
Mycobacterium smegmatis does not display functional redundancy in nitrate reductase enzymes
Authors: Cardoso Nicole C. , Papadopoulos Andrea O. , Kana Bavesh D.
Published: January 2021

Reduction of nitrate to nitrite in bacteria is an essential step in the nitrogen cycle, catalysed by a variety of nitrate reductase (NR) enzymes. The soil dweller, Mycobacterium smegmatis is able to assimilate nitrate and herein we set out to confirm the genetic basis for this by probing NR activity in mutants defective for putative nitrate reductase (NR) encoding genes. In addition to the annotated narB and narGHJI, bioinformatics identified three other putative NR-encoding genes: MSMEG_4206, MSMEG_2237 and MSMEG_6816. To assess the relative contribution of each, the corresponding gene loci were deleted using two-step allelic replacement, individually and in combination. The resulting strains were tested for their ability to assimilate nitrate and reduce nitrate under aerobic and anaerobic conditions, using nitrate assimilation and modified Griess assays. We demonstrated that narB, narGHJI, MSMEG_2237 and MSMEG_6816 were individually dispensable for nitrate assimilation and for nitrate reductase activity under aerobic and anaerobic conditions. Only deletion of MSMEG_4206 resulted in significant reduction in nitrate assimilation under aerobic conditions. These data confirm that in M. smegmatis, narB, narGHJI, MSMEG_2237 and MSMEG_6816 are not required for nitrate reduction as MSMEG_4206 serves as the sole assimilatory NR.
Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen dysregulates expression of MCL-1 by targeting FBW7
Authors: Kim Yeong Jun , Kim Yuri , Kumar Abhishek , Kim Chan Woo , Toth Zsolt , Cho Nam Hyuk , Lee Hye-Ra
Published: January 2021

Primary effusion lymphoma (PEL) is an aggressive B cell lymphoma that is etiologically linked to Kaposi’s sarcoma-associated herpesvirus (KSHV). Despite standard multi-chemotherapy treatment, PEL continues to cause high mortality. Thus, new strategies to control PEL are needed urgently. Here, we show that a phosphodegron motif within the KSHV protein, latency-associated nuclear antigen (LANA), specifically interacts with E3 ubiquitin ligase FBW7, thereby competitively inhibiting the binding of the anti-apoptotic protein MCL-1 to FBW7. Consequently, LANA-FBW7 interaction enhances the stability of MCL-1 by preventing its proteasome-mediated degradation, which inhibits caspase-3-mediated apoptosis in PEL cells. Importantly, MCL-1 inhibitors markedly suppress colony formation on soft agar and tumor growth of KSHV+PEL/BCBL-1 in a xenograft mouse model. These results strongly support the conclusion that high levels of MCL-1 expression enable the oncogenesis of PEL cells and thus, MCL-1 could be a potential drug target for KSHV-associated PEL. This work also unravels a mechanism by which an oncogenic virus perturbs a key component of the ubiquitination pathway to induce tumorigenesis.
Subsequent Primary Cancers of the Digestive System Among Childhood and Adolescent Cancer Survivors From 1975 to 2015 in the United States
Authors: Liu Jason J. , Chen Chuan-Yu , Giovannucci Edward , Wu Chun-Ying
Published: January 2021

INTRODUCTION:

Among survivors from first primary cancers that occurred during childhood and adolescence, their risks of developing subsequent primary digestive system cancers are not well understood. Therefore, we conducted the largest and most comprehensive analysis examining risks for diverse types of digestive system cancers after survival from a wide variety of first primary childhood and adolescent cancers.

METHODS:

We identified 41,249 patients diagnosed with first primary cancer from 1975 to 2015 before 20 years of age from 9 Surveillance, Epidemiology and End Results Program registries. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) for digestive system cancers were calculated controlling for age, sex, race, and calendar year.

RESULTS:

Among 41,249 cancer survivors, 133 developed subsequent primary digestive system cancer, with a median digestive system cancer diagnosis age of 37 years. The SIR and AER for any digestive system cancer were highest among survivors of bone cancer, lymphoma, and neuroblastoma. Among survivors from any first primary cancer, the SIR was significantly elevated for cancer of the esophagus, stomach, small intestine, large intestine, liver, and pancreas, whereas the AER was highest for large intestine cancer.

DISCUSSION:

Childhood and adolescent cancer survivors diagnosed from 1975 to 2015 have significantly elevated risks of digestive system cancers compared with the US general population. Our detailed findings may contribute to surveillance recommendations of childhood and adolescent cancer survivors and promote future studies to further understand mechanisms by which having various first primary cancers lead to subsequent primary digestive system cancers.
que são conceitos? A natureza e a existência de entidades abstratas de um ponto de vista materialista
Authors: Botti Ian
Published: January 2021

Este artigo aborda o problema da existência de objetos abstratos. O que são objetos tais como números? Eles existem, de fato? Uma terceira questão que surge a partir da lógica moderna é sobre a relação entre quantificação e existência. São apresentadas duas teorias historicamente importantes sobre a ontologia de objetos abstratos e o status ontológico do quantificador, a saber, a concepção quantificacional de existência predominante na filosofia analítica do século 20, e o meinongianismo, a qual ela pretendia responder. Em seguida, apresento as críticas de Branquinho (2015) as duas teorias, bem como o resultado da avaliação de ambas. Por fim, a concepção ficcionista de Mario Bunge (1981; 2010a; 2010b) é proposta como uma alternativa plausível, que concilia aspectos das teorias quantificacional e meinongiana que sobrevivem à crítica de Branquinho com uma visão de mundo materialista e informada pela ciência.
 
What are concepts? The nature and existence of abstract entities from a materialist point of view
Abstract: This article deals with the problem of the existence of abstract objects. What are objects such as numbers? Do they actually exist? A third question that arises from modern logic is about the relation between quantification and existence. Two historically important theories concerning the ontology of abstract objects and the ontological status of the quantifier are presented: first, the quantificational conception of existence, that was predominant in twentieth century analytical philosophy; second, the Meinongian conception, that analytical philosophers stood against. Then, Branquinho’s critical evaluation of both theories is presented, as well as the upshot of it (BRANQUINHO, 2015). Finally, Mario Bunge’s ficcionist conception is proposed as a plausible alternative, which conciliates the aspects of both already mentioned theories that survive Branquinho’s critique with a materialistic and scientifically informed worldview (1981; 2010a; 2010b).
Interventricular Septal Rupture in a 62-Year-Old Man With Familial Amyloid Polyneuropathy
Authors: Pidello Stefano , Simonato Erika , Orzan Fulvio , Frea Simone , Barreca Antonella , Rinaldi Mauro , Boffini Massimo
Published: January 2021

Cardiac involvement in familial amyloid polyneuropathy consists of arrhythmias, conduction disturbances, and heart failure. To our knowledge, heart rupture has never been described in association with this condition.

We report the case of a 62-year-old man with a 6-year history of refractory familial amyloid polyneuropathy who underwent liver transplantation. The operation was complicated by severe hypotension because the neuropathy involved the autonomic system. Perioperatively, the patient had a myocardial infarction, and during the next 10 days, a complete interventricular septal rupture developed, resulting in a systemic-to-pulmonary shunt. Coronary angiographic findings were normal. However, the shunt caused unstable hemodynamics, resulting in cardiogenic shock. An attempt to close the rupture percutaneously failed. The patient underwent successful heart transplantation 50 days later.

Macroscopic examination of the explanted heart showed thickening of both ventricles, septal rupture, and a gray scar in the interventricular septum around the cavity. Histopathologic examination revealed intramural amyloid angiopathy.

Our case shows that heart rupture can occur in patients with familial amyloid polyneuropathy who have no history of obstructive coronary artery disease, perhaps as a result of tissue fragility caused by amyloid angiopathy. Therefore, autonomic disturbances should be regarded with concern and promptly treated in the perioperative period.
Predicting Quality of Clinical Performance From Cardiology Fellowship Applications
Authors: Cullen Michael W. , Beckman Thomas J. , Baldwin Kristine M. , Engstler Gregory J. , Mandrekar Jay , Scott Christopher G. , Klarich Kyle W.
Published: January 2021

Variables in cardiology fellowship applications have not been objectively analyzed against applicants' subsequent clinical performance. We investigated possible correlations in a retrospective cohort study of 65 cardiology fellows at the Mayo Clinic (Rochester, Minn) who began 2 years of clinical training from July 2007 through July 2013. Application variables included the strength of comparative statements in recommendation letters and the authors' academic ranks, membership status in the Alpha Omega Alpha Honor Medical Society, awards earned, volunteer activities, United States Medical Licensing Examination (USMLE) scores, advanced degrees, publications, and completion of a residency program ranked in the top 6 in the United States. The outcome was clinical performance as measured by a mean of faculty evaluation scores during clinical training.

The overall mean evaluation score was 4.07 ± 0.18 (scale, 1–5). After multivariable analysis, evaluation scores were associated with Alpha Omega Alpha designation (β=0.13; 95% CI, 0.01–0.25; P=0.03), residency program reputation (β=0.13; 95% CI, 0.05–0.21; P=0.004), and strength of comparative statements in recommendation letters (β=0.08; 95% CI, 0.01–0.15; P=0.02), particularly in letters from residency program directors (β=0.05; 95% CI, 0.01–0.08; P=0.009).

Objective factors to consider in the cardiology fellowship application include Alpha Omega Alpha membership, residency program reputation, and comparative statements from residency program directors.
Effect of Laparoscopic Sleeve Gastrectomy on Heart Transplant Status in 4 Patients with Left Ventricular Assist Devices
Authors: Ryan Christopher T. , Santiago Adriana , Tariq Nabil , Lamba Harveen K.
Published: January 2021

Bariatric surgery helps many morbidly obese patients lose substantial weight. However, few data exist on its long-term safety and effectiveness in patients who also have continuous-flow left ventricular assist devices and in whom heart transplantation is contemplated. We retrospectively identified patients at our institution who had undergone ventricular assist device implantation and subsequent laparoscopic sleeve gastrectomy from June 2015 through September 2017, and we evaluated their baseline demographic data, preoperative characteristics, and postoperative outcomes.

Four patients (3 men), ranging in age from 32 to 44 years and in body mass index from 40 to 57, underwent sleeve gastrectomy from 858 to 1,849 days after left ventricular assist device implantation to treat nonischemic cardiomyopathy. All had multiple comorbidities.

At a median follow-up duration of 42 months (range, 24–47 mo), median body mass index decreased to 31.9 (range, 28.3–44.3) at maximal weight loss, with a median percentage of excess body mass index lost of 72.5% (range, 38.7%–87.4%). After achieving target weight, one patient was listed for heart transplantation, another awaited listing, one was kept on destination therapy because of positive drug screens, and one regained weight and remained ineligible.

On long-term follow-up, laparoscopic sleeve gastrectomy appears to be safe and feasible for morbidly obese patients with ventricular assist devices who must lose weight for transplantation consideration. Additional studies are warranted to evaluate this weight-loss strategy after transplantation and immunosuppression.
Ten-Year Survival With a Continuous-Flow Left Ventricular Assist Device and Aortic Valve Closure
Authors: Letsou George V. , Musfee Fadi I. , Lee Andrew D. , Cheema Faisal , Delgado Reynolds M. , Frazier O.H.
Published: January 2021

We report the long-term survival of a 46-year-old man supported with a HeartMate II continuous-flow left ventricular assist device after complex repair of a bicuspid aortic valve, anomalous left main coronary artery, and dilated aorta. He has been maintained on an anticoagulation regimen of warfarin and low-dose aspirin without problems for 10 years, during which he has worked continuously and productively. Device flow has been kept at 10,000 rpm. Possible contributors to this long-term success include proper alignment of the device inflow cannula, pericardial patch closure of the left ventricular outflow tract, and, notably, the remarkable freedom from mechanical failure of the continuous-flow left ventricular assist device. Whether the higher flow rate produced by the pericardial patch closure contributes to pump longevity is unknown and merits further investigation.
A Narrative Review of Limb Dominance: Task Specificity and the Importance of Fitness Testing
Authors: Virgile Adam , Bishop Chris
Published: January 2021

Virgile, A and Bishop, C. A narrative review of limb dominance: Task specificity and the importance of fitness testing. J Strength Cond Res 35(3): 846–858, 2021—Preferential limb function must be sustained through repetitious asymmetrical activities for continuous athletic development and, ultimately, optimal athletic performance. As such, the prevalence of limb dominance and between-limb differences is common in athletes. Severe between-limb differences have been associated with reductions in athletic performance and increased injury risk in athletes. However, in the current literature, the terms limb preference and limb dominance have been used interchangeably. Together, these terms include a limb that is subjectively preferred and one that is objectively dominant in 1 or more performance measures from a variety of athletic tasks. In this review, we (a) discuss reported correspondence between task-specific limb preference and limb dominance outcomes in athletes, (b) provide greater context and distinction between the terms limb preference and limb dominance, and (c) offer pragmatic strategies for practitioners to assess context-specific limb dominance. A limb that is subjectively preferred is not necessarily objectively dominant in 1 or more athletic qualities or sport-specific tasks. Further to this, a limb that is objectively superior in 1 task may not exhibit such superiority in a separate task. Thus, limb preference and limb dominance are both task-specific. As such, we propose that practitioners intentionally select tasks for limb dominance assessment which resemble the most relevant demands of sport. Because limb dominance profiles are inconsistent, we suggest that practitioners increase assessment frequency by integrating limb dominance testing into standard training activities. This will allow practitioners to better understand when changes reflect sport-specific adaptation vs. potential performance or injury ramifications.
Efficacy of Rest Redistribution During Squats: Considerations for Strength and Sex
Authors: Boffey David , Clark Nicolas W. , Fukuda David H.
Published: January 2021

Boffey, D, Clark, NW, and Fukuda, DH. Efficacy of rest redistribution during squats: Considerations for strength and sex. J Strength Cond Res 35(3): 586–595, 2021—This study examined the kinematic, perceptual, and heart rate responses to rest redistribution (RR) and traditional sets (TS) during the barbell back squat for men and women possessing a wide range of strength levels. Forty-five resistance-trained subjects (30 men and 15 women) performed 40 repetitions of the barbell squat with 65% 1RM load with TS (4 × 10 repetitions, 3-minute rest) or RR (10 × 4 repetitions, 1-minute rest), in a randomized order on days separated by ≥72 hours. The significance was set at p ≤ 0.05 for all statistical analyses. The mean velocity (MV) maintenance was significantly higher for RR compared with TS (87.70 ± 4.50% vs. 84.07 ± 4.48%, respectively; p < 0.01, d = 0.35). Rating of perceived exertion (active muscles) was significantly lower for RR compared with TS (5.38 ± 1.42 vs. 6.08 ± 1.43, respectively; p = 0.02, d = −0.35). Rating of perceived exertion (overall) was also significantly lower for RR compared with TS (5.60 ± 1.40 vs. 6.48 ± 1.49, respectively; p = 0.02, d = −0.37). The relative strength ratio (relative strength ratio; squat 1RM: body mass) was significantly correlated with the difference in MV maintenance between RR and TS (r = −0.34, p = 0.02). No sex-based differences (p > 0.05) were found for any dependent variables. Rest redistribution produced significantly higher mean HR (143.25 ± 21.11 vs. 135.05 ± 20.74, p < 0.01) and minimum HR (102.77 ± 19.58 vs. 95.97 ± 22.17, p < 0.01). Subjects were better able to maintain velocity with RR compared with TS, while experiencing less perceived effort. Rest redistribution can be recommended for both men and women, but very strong individuals may not improve their velocity maintenance with RR to the same extent as less strong individuals.
Development and Validation of a Dynamically Updated Prediction Model for Attrition From Marine Recruit Training
Authors: Dijksma Iris , Hof Michel H.P. , Lucas Cees , Stuiver Martijn M.
Published: January 2021

Dijksma, I, Hof, MHP, Lucas, C, and Stuiver, MM. Development and validation of a dynamically updated prediction model for attrition from Marine recruit training. J Strength Cond Res 36(9): 2523–2529, 2022—Whether fresh Marine recruits thrive and complete military training programs, or fail to complete, is dependent on numerous interwoven variables. This study aimed to derive a prediction model for dynamically updated estimation of conditional dropout probabilities for Marine recruit training. We undertook a landmarking analysis in a Cox proportional hazard model using longitudinal data from 744 recruits from existing databases of the Marine Training Center in the Netherlands. The model provides personalized estimates of dropout from Marine recruit training given a recruit's baseline characteristics and time-varying mental and physical health status, using 21 predictors. We defined nonoverlapping landmarks at each week and developed a supermodel by stacking the landmark data sets. The final supermodel contained all but one a priori selected baseline variables and time-varying health status to predict the hazard of attrition from Marine recruit training for each landmark as comprehensive as possible. The discriminative ability (c-index) of the prediction model was 0.78, 0.75, and 0.73 in week one, week 4 and week 12, respectively. We used 10-fold cross-validation to train and evaluate the model. We conclude that this prediction model may help to identify recruits at an increased risk of attrition from training throughout the Marine recruit training and warrants further validation and updates for other military settings.
Lower-Body Aquatic Training Prescription for Athletes
Authors: Holmberg Patrick M. , Gorman Adam D. , Jenkins David G. , Kelly Vincent G.
Published: January 2021

Holmberg, PM, Gorman, AD, Jenkins, DG, and Kelly, VG. Lower-body aquatic training prescription for athletes. J Strength Cond Res 35(3): 859–869, 2021—Traditionally prescribed to manage various medical ailments and promote healing, aquatic immersion may provide a favorable environment to undertake preparatory training tasks given its profound biological effects that extend across most homeostatic systems. In addition to understanding these effects, which are related to the fundamental principles of hydrodynamics, there is a need to consider the acute physiomechanical responses to alterations of key constraints associated with particular preparatory tasks. Evidence suggests that the manipulation of different constraints during aquatic training can enable a unique setting to complement, supplement, or supplant land-based programming to maintain or improve physical capacities in athletes without exacerbating physiological stress. Thus, this article focuses on the interplay of constraints and their associated outcomes to provide information that can be used to program lower-body aquatic training for athletes. In addition, the aim of the article is to summarize the literature on aquatic training to highlight the outcomes that occur when certain constraints are manipulated.