bluuebunny/crossref_metadata_2025 huggingface dataset:
My Data, My Choice? – German Patient Organizations’ Attitudes towards Big Data-Driven Approaches in Personalized Medicine. An Empirical-Ethical Study
Authors: Rauter Carolin Martina , Wöhlke Sabine , Schicktanz Silke
Published: February 2021

Personalized medicine (PM) operates with biological data to optimize therapy or prevention and to achieve cost reduction. Associated data may consist of large variations of informational subtypes e.g. genetic characteristics and their epigenetic modifications, biomarkers or even individual lifestyle factors. Present innovations in the field of information technology have already enabled the procession of increasingly large amounts of such data (‘volume’) from various sources (‘variety’) and varying quality in terms of data accuracy (‘veracity’) to facilitate the generation and analyzation of messy data sets within a short and highly efficient time period (‘velocity’) to provide insights into previously unknown connections and correlations between different items (‘value’). As such developments are characteristics of Big Data approaches, Big Data itself has become an important catchphrase that is closely linked to the emerging foundations and approaches of PM. However, as ethical concerns have been pointed out by experts in the debate already, moral concerns by stakeholders such as patient organizations (POs) need to be reflected in this context as well. We used an empirical-ethical approach including a website-analysis and 27 telephone-interviews for gaining in-depth insight into German POs’ perspectives on PM and Big Data. Our results show that not all POs are stakeholders in the same way. Comparing the perspectives and political engagement of the minority of POs that is currently actively involved in research around PM and Big Data-driven research led to four stakeholder sub-classifications: ‘mediators’ support research projects through facilitating researcher’s access to the patient community while simultaneously selecting projects they preferably support while ‘cooperators’ tend to contribute more directly to research projects by providing and implemeting patient perspectives. ‘Financers’ provide financial resources. ‘Independents’ keep control over their collected samples and associated patient-related information with a strong interest in making autonomous decisions about its scientific use. A more detailed terminology for the involvement of POs as stakeholders facilitates the adressing of their aims and goals. Based on our results, the ‘independents’ subgroup is a promising candidate for future collaborations in scientific research. Additionally, we identified gaps in PO’s knowledge about PM and Big Data. Based on these findings, approaches can be developed to increase data and statistical literacy. This way, the full potential of stakeholder involvement of POs can be made accessible in discourses around PM and Big Data.
Reappraising fear: is up-regulation more efficient than down-regulation?
Authors: Wiemer Julian , Rauner Milena M. , Stegmann Yannik , Pauli Paul
Published: February 2021

Catastrophizing thoughts may contribute to the development of anxiety, but functional emotion regulation may help to improve treatment. No study so far directly compared up- and down-regulation of fear by cognitive reappraisal. Here, healthy individuals took part in a cued fear experiment, in which multiple pictures of faces were paired twice with an unpleasant scream or presented as safety stimuli. Participants (N = 47) were asked (within-subjects) to down-regulate, to up-regulate and to maintain their natural emotional response. Valence and arousal ratings indicated successful up- and down-regulation of the emotional experience, while heart rate and pupil dilation increased during up-regulation, but showed no reduction in down-regulation. State and trait anxiety correlated with evaluations of safety but not threat stimuli, which supports the role of deficient safety learning in anxiety. Reappraisal did not modulate this effect. In conclusion, this study reveals evidence for up-regulation effects in fear, which might be even more efficient than down-regulation on a physiological level and highlights the importance of catastrophizing thoughts for the maintenance of fear and anxiety.
The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells
Authors: Bagaméry Fruzsina , Varga Kamilla , Kecsmár Kitti , Vincze István , Szökő Éva , Tábi Tamás
Published: February 2021

Recently neuronal insulin resistance was suggested playing a role in Alzheimer’s disease. Streptozotocin (STZ) is commonly used to induce impairment in insulin metabolism. In our previous work on undifferentiated SH-SY5Y cells the compound exerted cytotoxicity without altering insulin sensitivity. Nevertheless, differentiation of the cells to a more mature neuron-like phenotype may considerably affect the significance of insulin signaling and its sensitivity to STZ. We aimed at studying the influence of STZ treatment on insulin signaling in SH-SY5Y cells differentiated by retinoic acid (RA). Cytotoxicity of STZ or low serum (LS) condition and protective effect of insulin were compared in RA differentiated SH-SY5Y cells. The effect of insulin and an incretin analogue, exendin-4 on insulin signaling was also examined by assessing glycogen synthase kinase-3 (GSK-3) phosphorylation. STZ was found less cytotoxic in the differentiated cells compared to our previous results in undifferentiated SH-SY5Y cells. The cytoprotective concentration of insulin was similar in the STZ and LS groups. However, the right-shifted concentration–response curve of insulin induced GSK-3 phosphorylation in STZ-treated differentiated cells is suggestive of the development of insulin resistance that was further confirmed by the insulin potentiating effect of exendin-4. Differentiation reduced the sensitivity of SH-SY5Y cells for the non-specific cytotoxicity of STZ and enhanced the relative significance of development of insulin resistance. The differentiated cells thus serve as a better model for studying the role of insulin signaling in neuronal survival. However, direct cytotoxicity of STZ also contributes to the cell death.
Effects of oral macimorelin on copeptin and anterior pituitary hormones in healthy volunteers
Authors: Urwyler Sandrine A. , Lustenberger Sven , Drummond Juliana R. , Soares Beatriz Santana , Vogt Deborah R. , Ammer Nicola , Yuen Kevin C. J. , Ribeiro-Oliveira Antonio , Christ-Crain Mirjam
Published: February 2021

Purpose

The test with the highest diagnostic accuracy for diabetes insipidus is copeptin measurement after hypertonic saline infusion. However, the procedure is cumbersome and unpleasant due to rapid sodium increase. An oral stimulation test would be highly desirable. Macimorelin, an oral ghrelin agonist, is a newly approved diagnostic test for growth hormone (GH) deficiency, but its effects on copeptin/vasopressin are unknown and the effects on other pituitary hormones only scarcely investigated.

Methods

In this prospective, interventional, proof-of-concept study Copeptin and anterior pituitary hormones were measured in 28 healthy volunteers on two test days at baseline, 30, 45, 60, 90 and 120 min after a single dose of macimorelin (first visit: 0.5 mg/kg, second visit: 0.75 mg/kg).

Results

Baseline copeptin levels were 5.26 pmol/L [1.57, 6.81] and did not change after macimorelin intake (0.5 mg/kg: maximal median change 0.40 [− 0.49, 0.65] pmol/L, p = 0.442; 0.75 mg/kg: − 0.13 [− 0.45, 0.17] pmol/L, p = 0.442. Median GH levels increased from 3.67 mU/L with a maximal median change of 94.66 [IQR 56.5; 110.96] mU/L, p < 0.001. No effect was seen on cortisol, ACTH, LH and FSH levels. Prolactin (max. median change 100 [2.5; 146.5] mU/L, p = 0.004) and free thyroxine (fT4) (0.5 [0.2; 0.8] pmol/L, p < 0.001) increased, whereas TSH decreased (− 0.18 [− 0.22, − 0.09] mU/L, p < 0.001).

Conclusion

We confirm an increase of GH upon macimorelin in healthy volunteers. However, macimorelin did not stimulate copeptin and therefore does not provide an oral test alternative for the diagnosis of diabetes insipidus. Additionally, a stimulatory effect was seen for prolactin and fT4, but not for ACTH and gonadotropic hormones.

Registration

The trial was registered on ClinicalTrials.gov (NCT03844217) on February 18, 2019.
Indeterminacy, Ideology and Legitimacy in International Investment Arbitration: Controlling International Private Networks of Legal Governance?
Authors: Garcia Blesa Juan J.
Published: February 2021

This article connects the insights of post-realist scholarship about radical indeterminacy and its consequences for the legitimacy of adjudication to the current legitimacy crisis of the international investment regime. In the past few years, numerous studies have exposed serious shortcomings in investment law and arbitration including procedural problems and the substantive asymmetry of the rights protected. These criticisms have prompted a broad consensus in favor of amending the international investment regime and multiple reform proposals have appeared that appeal to the rule of law ideal as an instrument for increasing the acceptability of the international investment system. This article argues that the reliance of such proposals on jurisprudential approaches that fail to adequately accommodate the post-realist indeterminacy critique and take seriously the role of ideology in adjudication renders reform efforts unable to solve the legitimacy problems of the investment regime. The conclusions suggest the need to abandon implausible claims to depoliticization and face the methodological challenges posed by the promise of ideologically balanced assessments advanced by some rule of law theorists. The article finally points at the urgency to reform traditional approaches to doctrinal work in order to increase awareness of critical challenges and open up doctrinal methods to alternative methodological avenues.
A New Film Parameter for Rough Surface EHL Contacts with Anisotropic and Isotropic Structures
Authors: Hansen Jonny , Björling Marcus , Larsson Roland
Published: February 2021

Numerous tribological contacts worldwide rely on adequate lubrication quality for proper functionality. Despite this, there is no existing approach to accurately predict the state of lubrication. The default model since introduced in the 1960s—the $$\Lambda$$
Λ
-ratio, defined as the oil film thickness over the surface roughness height—is unpredictable and may yield erroneous results. Here, we put forward a framework for a new updated film parameter, $${\Lambda }^{*}$$

Λ

∗

, which accounts for the elasto-hydrodynamic lubrication (EHL) effects induced by surface irregularities on the microscopic scale (micro-EHL). This new film parameter was validated in ball-on-disc tribological tests with engineering surfaces comprising isotropic and anisotropic structures. As expected, the new model was found to accurately predict the experimentally measured true mixed and full-film EHL regimes. The ability to accurately predict the mode of lubrication represents a major advance in designing tribological interfaces for optimal efficiency and durability.
Does river channelization increase the abundance of invasive crayfish? Survey of Faxonius limosus in small Central European streams
Authors: Bonk Maciej , Bobrek Rafał
Published: February 2021

The aim of this study was to assess whether regulated river reaches show higher numbers of the spiny cheek crayfishFaxonius limosus, a common freshwater invader in Europe. Man-made alterations of riverine habitats may increase their susceptibility to biological invasions. This phenomenon is commonly studied in the context of dam reservoirs; however, the impact of river channelization and the resulting riverine habitat homogenization on the success of invasive species are mostly lacking. Surveys were conducted in natural and channelised river stretches in five rivers of south-central Poland. General linear mixed model analysis showed that crayfish abundance is usually higher at sites located within regulated reaches. The likely reason for the detected differences in abundance of crayfish may be related to decreased food-web complexity and lack of predators in a homogenised habitat. The results suggest that the channelization of small watercourses may increase the abundance of invasive speciesF. limosusand its pressure on native European crayfish. However, due to limited data obtained in field, our study should be considered as a pilot one.
Attitudes Toward Robots as Equipment and Coworkers and the Impact of Robot Autonomy Level
Authors: Latikka Rita , Savela Nina , Koivula Aki , Oksanen Atte
Published: February 2021

Increasingly, people must interact with robot technologies. In this research, we examined attitudes toward robots as equipment and as coworkers and whether these attitudes are affected by the autonomy of the robot among participants living in the United States (Study 1: N = 1003; Study 2: N = 969). Study 1 revealed that respondents had a more positive attitude toward robots as equipment than as coworkers. Technology use self-efficacy and prior robot use experience were associated with more positive attitudes toward both robot positions. Having a degree in engineering or technology was associated with a positive attitude toward robot coworkers, while neuroticism was associated with a negative attitude. Additionally, technology use self-efficacy was found to have a significant indirect effect on the associations between openness and attitudes toward robots as well as conscientiousness and attitudes toward robots. In Study 2, a three-group online survey experiment showed that teleoperated robots and semi-autonomous robots were preferred as equipment over fully autonomous robots. The robots’ autonomy level did not impact attitude toward robot coworkers. Overall, the results suggest that people prefer non-autonomous robots over autonomous robots in the work-life context. The studies provide a comprehensive overview of attitudes toward robots as both equipment and coworkers, and the key predictors of the noted attitudes. The results suggest a readiness for shared autonomy between a human operator and a robot. This should be considered in the design and successful implementation of new robot technologies in workplaces.
Immunitarianism: defence and sacrifice in the politics of Covid-19
Authors: Ajana Btihaj
Published: February 2021

As witnessed over the last year, immunity emerged as one of most highly debated topics in the current Covid-19 pandemic. Countries around the globe have been debating whether herd immunity or lockdown is the best response, as the race continues for the development and rollout of effective vaccines against coronavirus and as the economic costs of implementing strict containment measures are weighed against public health costs. What became evident all the more is that immunity is precisely what bridges between biological life and political life in the current climate, be it in terms of the contentious notion of herd immunity, the geopolitical struggle for vaccines, or the possible emergence of “Covid-elite”, i.e. holders of so-called “immunity passports”. Immunity, as such, is certainly not only a matter of science and biology alone, but is inherently political in the way that pandemics themselves are often highly politicised. Drawing on the work of Roberto Esposito and other literature from the field of biopolitics and immunology, this paper provides a critical examination of the concept of immunity in light of the recent events, highlighting the intersections between the politics of defence and the politics of sacrifice which animate governments’ immunitary responses to the Covid-19 pandemic. The paper ends with a discussion on the forms of solidarity and local initiatives that have been mobilised during the current pandemic and their potential for an affirmative form of biopolitics. Overall, the main aim of this paper is to provide a critical cultural and philosophical analysis of Covid-19 debates and responses and a nuanced account on the biopolitical effects of the current pandemic, highlighting the paradoxical nature of immunity which straddles at once negative practices of defence and sacrifice as well as affirmative forms of community and solidarity beyond state apparatuses.
Using Composite Phenotypes to Reveal Hidden Physiological Heterogeneity in High-Altitude Acclimatization in a Chinese Han Longitudinal Cohort
Authors: Li Yi , Ma Yanyun , Wang Kun , Zhang Menghan , Wang Yi , Liu Xiaoyu , Hao Meng , Yin Xianhong , Liang Meng , Zhang Hui , Wang Xiaofeng , Chen Xingdong , Zhang Yao , Duan Wenyuan , Kang Longli , Qiao Bin , Wang Jiucun , Jin Li
Published: February 2021

Altitude acclimatization is a human physiological process of adjusting to the decreased oxygen availability. Since several physiological processes are involved and their correlations are complicated, the analyses of single traits are insufficient in revealing the complex mechanism of high-altitude acclimatization. In this study, we examined these physiological responses as the composite phenotypes that are represented by a linear combination of physiological traits. We developed a strategy that combines both spectral clustering and partial least squares path modeling (PLSPM) to define composite phenotypes based on a cohort study of 883 Chinese Han males. In addition, we captured 14 composite phenotypes from 28 physiological traits of high-altitude acclimatization. Using these composite phenotypes, we applied k-means clustering to reveal hidden population physiological heterogeneity in high-altitude acclimatization. Furthermore, we employed multivariate linear regression to systematically model (Models 1 and 2) oxygen saturation (SpO2) changes in high-altitude acclimatization and evaluated model fitness performance. Composite phenotypes based on Model 2 fit better than single trait-based Model 1 in all measurement indices. This new strategy of using composite phenotypes may be potentially employed as a general strategy for complex traits research such as genetic loci discovery and analyses of phenomics.
The Ultrafast and Accurate Mapping Algorithm FANSe3: Mapping a Human Whole-Genome Sequencing Dataset Within 30 Minutes
Authors: Zhang Gong , Zhang Yongjian , Jin Jingjie
Published: February 2021

Aligning billions of reads generated by the next-generation sequencing (NGS) to reference sequences, termed “mapping”, is the time-consuming and computationally-intensive process in most NGS applications. A Fast, accurate and robust mapping algorithm is highly needed. Therefore, we developed the FANSe3 mapping algorithm, which can map a 30 × human whole-genome sequencing (WGS) dataset within 30 min, a 50 × human whole exome sequencing (WES) dataset within 30 s, and a typical mRNA-seq dataset within seconds in a single-server node without the need for any hardware acceleration feature. Like its predecessor FANSe2, the error rate of FANSe3 can be kept as low as 10–9 in most cases, this is more robust than the Burrows–Wheeler transform-based algorithms. Error allowance hardly affected the identification of a driver somatic mutation in clinically relevant WGS data and provided robust gene expression profiles regardless of the parameter settings and sequencer used. The novel algorithm, designed for high-performance cloud-computing after infrastructures, will break the bottleneck of speed and accuracy in NGS data analysis and promote NGS applications in various fields. The FANSe3 algorithm can be downloaded from the website: http://www.chi-biotech.com/fanse3/.
African Responses to COVID-19: The Reckoning of Agency?
Authors: Patterson Amy S. , Balogun Emmanuel
Published: February 2021

Although the COVID-19 pandemic had claimed over one million lives globally by late 2020, Africa had avoided a massive outbreak. Patterson and Balogun analyze pandemic responses by the Africa Centres for Disease Control and Prevention and various states collaborating with civil society. They argue that responses display forms of agency rooted in contextually relevant expertise, pan-African solidarity, and lessons learned about health messaging and community mobilization from previous health crises. Yet collaboration has not always been harmonious, as actors have adopted various approaches in their interactions with global health institutions and civil society partnerships, and they have actively debated the use of traditional medicine as a COVID-19 treatment.
STRONG COLORINGS OVER PARTITIONS
Authors: CHEN-MERTENS WILLIAM , KOJMAN MENACHEM , STEPRĀNS JURIS
Published: February 2021

A strong coloring on a cardinal$\kappa $is a function$f:[\kappa ]^2\to \kappa $such that for every$A\subseteq \kappa $of full size$\kappa $, every color$\unicode{x3b3} <\kappa $is attained by$f\restriction [A]^2$. The symbol$$ \begin{align*} \kappa\nrightarrow[\kappa]^2_{\kappa} \end{align*} $$asserts the existence of a strong coloring on$\kappa $.

We introduce the symbol$$ \begin{align*} \kappa\nrightarrow_p[\kappa]^2_{\kappa} \end{align*} $$which asserts the existence of a coloring$f:[\kappa ]^2\to \kappa $which isstrong over a partition$p:[\kappa ]^2\to \theta $. A coloringfis strong overpif for every$A\in [\kappa ]^{\kappa }$there is$i<\theta $so that for every color$\unicode{x3b3} <\kappa $is attained by$f\restriction ([A]^2\cap p^{-1}(i))$.

We prove that whenever$\kappa \nrightarrow [\kappa ]^2_{\kappa }$holds, also$\kappa \nrightarrow _p[\kappa ]^2_{\kappa }$holds for an arbitrary finite partitionp. Similarly, arbitrary finitep-s can be added to stronger symbols which hold in any model of ZFC. If$\kappa ^{\theta }=\kappa $, then$\kappa \nrightarrow _p[\kappa ]^2_{\kappa }$and stronger symbols, like$\operatorname {Pr}_1(\kappa ,\kappa ,\kappa ,\chi )_p$or$\operatorname {Pr}_0(\kappa ,\kappa ,\kappa ,\aleph _0)_p$, also hold for an arbitrary partitionpto$\theta $parts.

The symbols$$ \begin{gather*} \aleph_1\nrightarrow_p[\aleph_1]^2_{\aleph_1},\;\;\; \aleph_1\nrightarrow_p[\aleph_1\circledast \aleph_1]^2_{\aleph_1},\;\;\; \aleph_0\circledast\aleph_1\nrightarrow_p[1\circledast\aleph_1]^2_{\aleph_1}, \\ \operatorname{Pr}_1(\aleph_1,\aleph_1,\aleph_1,\aleph_0)_p,\;\;\;\text{ and } \;\;\; \operatorname{Pr}_0(\aleph_1,\aleph_1,\aleph_1,\aleph_0)_p \end{gather*} $$hold for an arbitrary countable partitionpunder the Continuum Hypothesis and are independent over ZFC$+ \neg $CH.
Early Byzantine sigillographic evidence from western Anatolia: sixth- and seventh-century lead seals from Bergama (ancient Pergamon)
Authors: Laflı Ergün , Seibt Werner , Çağlayan Doğukan
Published: February 2021

This article presents twelve lead seals from the Museum of Bergama (ancient Pergamon), dating from the late sixth to the early eighth century. We offer a descriptive catalogue of these early Byzantine seals preserved in a western Turkish museum. In the introduction, seals excavated in Pergamon as well as seals referring to Pergamon are briefly discussed. The owners of the twelve seals in the museum were primarily ecclesiastical or legal dignitaries who were probably active in Pergamon, in southwestern Mysia, in Aeolis or in Lydia.
The Judicial Construction of Older Consumers’ Rights: A Qualitative Case-Law Analysis
Authors: Segal Michal , Mor Sagit , Doron Israel (Issi)
Published: February 2021

Courts conceptualize and construct the phenomenon of consumer rights violations against older people in different ways. This qualitative analysis of court decisions explores the meanings that Israeli courts have attributed to the fact that the victim was an older consumer. Specific objectives include determining whether existing consumer protections for older consumers are effective, how the relevant provisions of consumer protection law are expressed in application of case law, and how courts structure the issue in their rulings. Analysis has revealed a tension between two judicial approaches: assumption of older consumers as inherently vulnerable and meriting special-class protection, versus application of general consumer protection law attending to actual plaintiffs’ or defendants’ characteristics. Critical reading of the judgments leads to construction and suggestion of a tiered approach to adjudicating consumer protection cases that protects the vulnerable older consumer without falling into a trap of unwarranted ageism.
The influence of two wildfires and biological control agents on the population dynamics of Melaleuca quinquenervia in a seasonally inundated wetland
Authors: Tipping Philip W. , Martin Melissa R. , Foley Jeremiah R. , Pierce Ryan M. , Gettys Lyn A.
Published: February 2021

The potential of Melaleuca quinquenervia (Cav.) S.T. Blake to reinvade cleared areas was evaluated over a 13-yr period that included two wildfires and the introduction of biological control agents. The first wildfire occurred in 1998 and was followed by a mean of 591.5 recruited seedlings m−2. Recruits from that fire were cleared 7 yr later in July 2005 for a second experiment to evaluate seedling recruitment into cleared areas. Seed rain, seedling recruitment and mortality, and sapling growth rates were measured in four plots located around individual large reproductive trees. A second natural wildfire in 2007 burned through those plots, leading to increases in seed rain followed by a pulse in recruitment of 21.04 seedlings m−2, 96.5% fewer than after the 1998 fire. Recruits in half of the plots around each tree were then treated with regular applications of an insecticide to restrict herbivory by biological control agents, while herbivory was not restricted in the other half. There was no difference in seedling mortality between treatments 1,083 d post-fire (2007) with 96.6% seedling mortality in the unrestricted herbivory treatment and 89.4% mortality in the restricted herbivory treatment. Recruits subjected to the restricted herbivory treatment grew taller than those in the unrestricted herbivory treatment, 101.3 cm versus 37.4 cm. Many of the recruits were attacked by the biological control agents, which slowed their growth. Although solitary M. quinquenervia trees retain some capacity to reinvade areas under specific circumstances, there was a downward trend in their overall invasiveness at this site, with progressively smaller recruitment cohorts due to biological control agents. Land managers should prioritize removing large reproductive trees over treating recently recruited populations, which can be left for many years for the biological control agents to suppress before any additional treatment would be needed.
Pursuing Frugal Innovation for Sustainability at the Grassroots Level
Authors: Hossain Mokter , Levänen Jarkko , Wierenga Marleen
Published: February 2021

Firms are often criticized for their reluctance to embrace sustainability in their business strategies. Frugal innovation is a recent concept that represents a new way for firms to serve underserved customers in developing countries while also promoting sustainability. Based on three cases of frugal innovation at the grassroots level in India, this article demonstrates how frugal innovation presents a promising way to tackle some of today's pressing societal problems with new business models. We use a range of parameters for economic, social, and environmental sustainability to strengthen the case for frugal innovation. This article attempts to inspire scholars to consider frugal innovation further in their future research endeavors and encourage firms to integrate it into their existing business models.
Helminth parasites of shags (Phalacrocoracidae) from the Otago region of southern New Zealand
Authors: Presswell B. , Bennett J.
Published: February 2021

A total of 61 specimens representing five species of shag – Auckland Island shagLeucocarbo colensoi, little pied shagMicrocarbo melanoleucos brevirostris, black shagPhalacrocorax carbo novaehollandiae, Otago shagLeucocarbo chalconotusand spotted shagPhalacrocorax punctatus– from the coast around Otago, South Island, New Zealand, were examined for helminths. A total of 18 helminth species was found: six nematodes (Anisakis pegreffi,Contracaecum rudolphiiE,Baruscapillariasp.,Cosmocephalus jaenschi,Ingliseria cirrohamata,Desmidocercella australis), four trematodes (Apatemonsp. ‘jamiesoni’,Cardiocephaloides ovicorpus,Apophallussp., Microphallidae gen. sp.), four cestodes (Microsomacanthus cormoranti,Microsomacanthussp.,Paradilepis urceina,Tetrabothriussp.) and four acanthocephalans (Andracantha leucocarboi,A.sigma,Corynosoma hannae,Profilicollis novaezelandensis). Descriptions are provided for females ofC.jaenschiandD.australis, which were previously undescribed. The data include 20 new host records and seven new locality records. New 18S ribosomal DNA and internal transcribed spacer (ITS1 and ITS2) DNA sequences have been provided where specimen conditions permitted. These data add considerably to our sparse knowledge of helminths in New Zealand shags, and provide a baseline for observations of change in the future.
Correlation between nasal mucosal temperature change and the perception of nasal patency: a literature review
Authors: Tjahjono R , Singh N
Published: February 2021

Background

The mechanism of nasal airflow sensation is poorly understood. This study aimed to examine the role of nasal mucosal temperature change in the subjective perception of nasal patency and the methods by which it can be quantified.

Method

Medline and PubMed database searches were performed to retrieve literature relevant to the topic.

Results

The primary mechanism producing the sensation of nasal patency is thought to be the activation of transient receptor potential melastatin family member 8 (‘TRPM8’), a thermoreceptor that is activated by nasal mucosal cooling. Computational fluid dynamics studies have demonstrated that increased airflow and heat flux are correlated with better patient-reported outcome measure scores. Similarly, physical measurements of the nasal cavity using temperature probes have shown a correlation between lower nasal mucosal temperatures and better patient-reported outcome measure scores.

Conclusion

Nasal mucosal temperature change may be correlated with the perception of improved nasal patency. Future research should quantify the impact of mucosal cooling on the perception of nasal airway obstruction.
Management of ENT emergencies during the coronavirus disease 2019 pandemic
Authors: Stansfield J , Dobbs S , Harrison R , Lee K , Sharma S , Okour K , Agrawal S , Miah M S
Published: February 2021

Background

Coronavirus disease 2019 imposed dramatic changes on ENT service delivery. Pre-pandemic, such changes would have been considered potentially unsafe. This study outlines the impact of lockdown on the incidence and management of ENT emergencies at a large UK centre.

Methods

After modification of pre-pandemic guidelines, ENT emergency referrals data during the UK lockdown were prospectively captured. A comparative analysis was performed with retrospective data from a corresponding period in 2019.

Results

An overall reduction (p< 0.001) in emergency referrals (n= 119) and admissions (n= 18) occurred during the lockdown period compared to the 2019 period (432 referrals and 290 admissions). Specifically, there were reduced admission rates for epistaxis (p< 0.0001) and tonsillar infection (p< 0.005) in the lockdown period. During lockdown, 90 per cent of patients requiring non-dissolvable nasal packing were managed as out-patients.

Conclusions

Coronavirus disease 2019 compelled modifications to pre-pandemic ENT guidelines. The enforced changes to emergency care appear to be safe and successfully adopted. Arguably, the measures have both economic and patient-related implications post-coronavirus disease 2019 and during future similar pandemics and lockdowns.
Description and phylogenetic relationships of a new genus of Planoceridae (Polycladida, Acotylea) from Shimoda, Japan
Authors: Oya Yuki , Kajihara Hiroshi
Published: February 2021

We establish a new genus of planocerid polyclad,Heteroplanoceragen. nov., based on a new species,H. katoisp. nov., collected at a depth of 245 m off the coast of the Izu Peninsula, West Pacific, Japan.Heteroplanoceragen. nov. is distinguished from other planocerid genera by the following characteristics: (i) a pair of nuchal tentacles, (ii) a muscular bulb, (iii) a pair of spermiducal bulbs (instead of a seminal vesicle), (iv) a free prostatic vesicle, (v) a pair of accessory organs with teeth, (vi) a Lang's vesicle, and (vii) the lack of a bursa copulatrix. We provide a partial sequence of the cytochromecoxidase subunit I (COI) gene (712 bp) as a DNA barcode of the new species. Furthermore, we estimate the phylogenetic position ofHeteroplanoceragen. nov. among Planoceridae based on partial sequences of COI and 16S, 18S, and 28S ribosomal DNA. Based on our findings, we discuss the evolution and function of the (i) vaginal cuticularized structure and (ii) accessory organs among planocerid flatworms.
A Roundtable on Rupa Viswanath'sThe Pariah Problem: Caste, Religion, and the Social in Modern Indiaand the Study of Caste
Authors: PENNINGTON BRIAN K. , CHANDRA UDAY , RAMBERG LUCINDA , SHERINIAN ZOE , LEE JOEL , VISWANATH RUPA
Published: February 2021

In this roundtable discussion, five scholars of modern India with diverse methodological training examine aspects of Rupa Viswanath's 2014 book,The Pariah Problem: Caste, Religion, and the Social in Modern India, and assess its arguments and contributions. This book has made strong challenges to the scholarly consensus on the nature of caste in India, arguing that, in the Madras presidency under the British, caste functioned as a form of labour control of the lowest orders and, in this roundtable, she calls colonial Madras a ‘slave society’. The scholars included here examine that contention and the major subsidiary arguments on which it is based. Uday Chandra identifiesThe Pariah Problemwith a new social history of caste and Dalitness. Brian K. Pennington links the ‘religionization’ of caste that Viswanath identifies to the contemporary Hindu right's concerns for religious sentiment and authenticity. Lucinda Ramberg takes up Viswanath's account of the constitution of a public that excluded the Dalit to inquire further about the gendered nature of that public and the private realm it simultaneously generated. Zoe Sherinian calls attention to Viswanath's characterization of missionary opposition to social equality for Dalits and examines missionary and Dalit discourses that stand apart from those that Viswanath studied. Joel Lee extends some of Viswanath's claims about the Madras presidency by showing strong parallels to social practices in colonial North India. Finally, Viswanath's own response addresses the assessments of her colleagues.
Precision psychiatry: promise for the future or rehash of a fossilised foundation?
Authors: Köhne Annemarie C. J. , van Os Jim
Published: February 2021

Precision psychiatry is currently described as an approach that would bring significant advance to psychiatric clinical practice. Theaim of this article is to investigate Precision Psychiatry’s promise for the future; should we substantially invest in this new approach? Thearticle is based on a review of the literature and reports a conceptual analysis. A critical examination of Precision Psychiatry’s foundationsshows us that its fundaments are obsolete and flawed: we cannot reduce mental suffering to essences in biology. It is problematic to statethat biological processes hold and capture qualia and meaning, and in themselves and without context would hold and capture somethinglike abnormality. Despite its good efforts, precision psychiatry does not represent a sufficiently promising alternative to the phenotyping thatcomes with the current classification systems.
Blame Avoidance in China's Cadre Responsibility System
Authors: Li Jiayuan , Ni Xing , Wang Rui
Published: February 2021

This article contends that prior research on the behaviour of Chinese local cadres pays limited attention to their motivation for avoiding blame. Using qualitative data from three field studies conducted in Guangdong province, the study focuses on blame avoidance in the cadre responsibility system, which is recognized as an important instrument for state capacity building. Our analysis uncovers three major discursive strategies used by grassroots cadres to manage blame either before or after it is apportioned: de-legitimating performance standards, re-attributing blame and transferring blame risk. We find that local cadres have a role as blame makers in shifting blame and accusations. This finding challenges the conventional view, which typically sees local officials as blame takers. The article concludes by elaborating on the wider implications of this finding and proposing avenues for future research.
Observation of multiple Bragg reflections accompanying forbidden Si(002) reflection in bent-perfect Si crystal
Authors: Mikula P. , Vrána M. , Šaroun J. , Ryukhtin V.
Published: February 2021

Strong multiple Bragg reflections (MBRs) which can be realized in a bent-perfect-crystal (BPC) slab provide a monochromatic beam of excellent resolution parameters. For identifying MBR effects in the BPC Si crystal, we used the method of azimuthal rotation of the crystal lattice around the scattering vector of the primary forbidden Si(200) reflection for a fixed chosen wavelength. In this paper, several azimuthal scans searching strong MBR effects with the intention of a possible practical exploitation for very high-resolution diffractometry are presented.
Chinese perspectives on the ad bellum/in bello relationship and a cultural critique of the ad bellum/in bello separation in international humanitarian law
Authors: Liang Zhuo
Published: February 2021

The intriguing relationship between jus ad bellum and jus in bello has provoked perennial academic debates. This article examines this issue from Chinese perspectives and offers a cultural critique of the well-entrenched norm of the ad bellum/in bello separation in international humanitarian law. Based on its distinctive traditional perception of the world order and the meaning of war, China embraces a holistic understanding of the ad bellum/in bello relationship. This relationship is construed as essentially harmonized. The cardinal moral principle underpinning it is that a just war should be conducted in a just way. The ad bellum/in bello separation in international humanitarian law has a Western origin, and the rationale behind it intimates Western sensitivity to the European just war tradition in which jus in bello was parasitic on jus ad bellum. It is assumed that jus ad bellum and jus in bello are irreconcilably in conflict once they come into contact with one another. This assumption is followed by a widely-held belief that any attempt to reconnect the two concepts would bring nothing but the subordination of jus in bello to jus ad bellum as experienced in European just war and, consequently, the collapse of the former. Chinese perspectives nevertheless evidence that this conventional line of thinking, hampering scholars from thinking beyond the sealed ad bellum/in bello separation, is not sound. A proposal for a more constructive solution should be taken into consideration.
Re-estimation of basic reproduction number of COVID-19 based on the epidemic curve by symptom onset date
Authors: Hong K. , Yum S. J. , Kim J. H. , Chun B. C.
Published: February 2021

Previous studies have reported the basic reproduction number (R0) of coronavirus disease from publicly reported data that lack information such as onset of symptoms, presence of importations or known super-spreading events. Using data from the Republic of Korea, we illustrated how estimates of R0 can be biased and provided improved estimates with more detailed data. We used COVID-19 contact trace system in Korea, which can provide symptom onset date and also serial intervals between contacted people. The total R0 was estimated as 2.10 (95% confidence interval (CI) 1.84–2.42). Also, early transmission of COVID-19 differed by regional or social behaviours of the population. Regions affected by a specific church cluster, which showed a rapid and silent transmission under non-official religious meetings, had a higher R0 of 2.40 (95% CI 2.08–2.77).
COVID-19 and Beyond: The Need for Copathy and Impartial Advisers
Authors: Häyry Matti
Published: February 2021

When humanity has either suppressed coronavirus disease 2019 or learned to come to terms with its continued existence, governments and corporations probably return to their prepandemic stances. Solutions to the world’s problems are sought from technology and business innovations, not from considerations of equality and well-being for all. This is in stark contrast with the pandemic-time situation. Many governments, at least initially, listened to the recommendations of expert advisers, most notably public health authorities, who proceeded from considerations of equality and common good. I suggest that we should continue on this path when the immediate threat of the disease is over. Other crises are already ongoing—poverty, conflicts, climate change, financial bubbles, and so on—and it would be good to use expert knowledge rather than interests and ideologies in dealing with them. To assist in this, I outline the characteristics of a new kind of counsellor,impartial adviser, who is normatively motivated by a sense ofcopathyand who takes into account all views, nice and not-so-nice alike. I illustrate the nature and ideological orientation of copathic impartial advisers by placing them on a map of justice and examining their relationships with the main political moralities of our time.
The Great Equalizer? Gender, Parenting, and Scholarly Productivity During the Global Pandemic
Authors: Breuning Marijke , Fattore Christina , Ramos Jennifer , Scalera Jamie
Published: February 2021

Has the global COVID-19 pandemic negatively impacted the scholarly productivity of academics? Do gender and parenting magnify its effect? To obtain insight into the changes the pandemic has wrought in the lives and careers of women and parents in academia, we surveyed scholars in political science and international studies. The survey was in the field during the period in which many academics were experiencing shelter-at-home orders and adjusting to a new reality. It captures initial reactions to changed circumstances as well as the fears and anticipated consequences of the disruptions. We find that perceptions of a negative impact are broadly shared. The open-ended responses suggest that the pandemic may widen the gender and parent productivity gaps. Although further analysis is needed to better understand the effect of the pandemic on scholarly productivity, we conclude that the pandemic exacerbates existing structural inequalities.
Reducing the Carbon Footprint of Academic Conferences by Online Participation: The Case of the 2020 Virtual European Consortium for Political Research General Conference
Authors: Jäckle Sebastian
Published: February 2021

This article investigates the impact that the decision to switch an academic conference to an online event had on its carbon footprint. Using the example of the biggest European Political Science conference, the European Consortium for Political Research General Conference, it comprehensively estimates the amount of greenhouse gases produced by the virtual event and by the hypothetical case, if the event had taken place physically, including emissions from electricity usage, travel, heating, and catering. The carbon footprint of the virtual conference turned out to be between at least 97 and 200 times smaller than it would have been if the meeting had taken place in person. Hybrid conferences, particularly if those participants from far away join the event online, combined with the promotion of land-bound travel for those attending in person—even if this means longer travel times than flying—could be a feasible compromise to reduce emissions by almost 90%.
A RETROSPECTIVE LOOK AT “THE HAYEK STORY”: ROUNDABOUTNESS, STICKY CONSUMPTION, AND SEQUESTERED CAPITAL
Authors: McClure James E. , Thomas David Chandler , Spector Lee C.
Published: February 2021

Friedrich Hayek’s business cycle theory withered throughout the 1930s as he admitted that its underlying model of Böhm-Bawerkian roundaboutness was incomplete and inadequate. In 1934, Hayek started a two-volume book on capital theory, completing only one volume in 1941. Curiously, Hayek ([1941] 2009) cites John Hicks’s (1939) Value and Capital but not the financial measure of roundaboutness that Hicks suggested as a substitute for Böhm-Bawerkian roundaboutness. In 1967, in “The Hayek Story,” Hicks criticized the inexplicable lags. Hayek maintained his view that consumption was sticky and responded to Hicks with a mound-of-honey analogy. Nevertheless, Hayek maintained that his business cycle theory was fundamentally correct and continued to hope that others might someday discover a capital structure theory to undergird it. Toward fulfilling Hayek’s hope, we suggest augmenting the canonical stages of production with a sequestered-capital stage where products are invented, productized, and inventoried prior to launch, uncoordinated by observable prices.
Dietary patterns associated with obesity outcomes in adults: an umbrella review of systematic reviews
Authors: Seifu Canaan Negash , Fahey Paul P , Hailemariam Tewodros G , Frost Steven A , Atlantis Evan
Published: February 2021

Objective:

The aim of this umbrella review was to summarise the evidence from existing systematic reviews on the association between different dietary patterns (DP) and overweight or obesity outcomes in adults.

Design:

We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and searched the MEDLINE, EMBASE, CINAHL, Cochrane, Scopus, and Web of Science for systematic reviews reporting on DP and weight gain or overweight/obesity outcomes.

Result:

We identified 16 systematic reviews with 143 unique studies published between 2001 and 2019. Overall quality scores ranged from 4 to 10. Six reviews in 2/11 cohort and 6/19 cross-sectional studies reported (statistically significant) decreased OR for obesity (range: 0·53 to 0·73 and 0·35 to 0·88, respectively) associated with the Mediterranean diet. Five reviews in 5/15 cohort and 10/45 cross-sectional studies reported an inverse association between diet quality and weight gain or BMI (β range: –1·3 to –0·09). Two reviews in 1/3 cohort and 1/2 cross-sectional studies reported a decreased risk of obesity (OR = 0·76) and weight gain (OR = 0·26), respectively, with fruit and vegetable intake. Five reviews of mixed DP in 3/40 cross-sectional studies reported an increased prevalence of obesity (OR = 1·19) or abdominal obesity (OR range: 1·07 to 1·27) with the Korean diet pattern.

Conclusions:

Our umbrella review confirms the hypothesis that Mediterranean-type DP reduce the risk of obesity in adults. Although population-specific evidence of effective interventions is needed, characteristics of Mediterranean-type DP are important considerations for national obesity prevention strategies.
Creation, Evolution, and “The New Cosmic Philosophy”: William Todd Martin's Critique of Herbert Spencer
Authors: Holmes Andrew R. , Livingstone David N.
Published: February 2021

This article explores the religious response of one neglected writer to the evolutionary philosophy of Herbert Spencer. William Todd Martin was a minister of the Presbyterian Church in Ireland and in 1887 publishedThe Evolution Hypothesis: A Criticism of the New Cosmic Philosophy. The work demonstrates the essentially contested nature of “evolution” and “creation” by showing how a self-confessed creationist could affirm an evolutionary understanding of the natural world and species transformation. Martin's approach reflected a transatlantic Presbyterian worldview that saw the harmony of science and religion on the basis of Calvinism, Baconianism and Scottish Common Sense philosophy. Martin's critique is also relevant to issues that continue to animate philosophers of science and religion, including the connections between mind and matter, morality and consciousness in a Darwinian framework, and the relationship between subjective conscious experience and evolutionary physicalism. Martin was able to anticipate these debates because his critique was essentially philosophical and theological rather than biological and biblicist.