bluuebunny/crossref_metadata_2025 huggingface dataset:
A exegese de Jerônimo exemplificada no Comentário ao Profeta Oseias / Jerome's exegesis exemplified in the Commentary on the Prophet Hosea
Authors: Corrêa Lima Maria de Lourdes
Published: October 2022

Resumo: O presente trabalho detém-se sobre a análise do comentário de Jerônimo ao capítulo 11 de Oseias. Sua finalidade é identificar o procedimento exegético seguido, compreendendo-o em suas linhas estruturantes, em suas bases e seus corolários. Para tanto, situa o comentário a Oseias no conjunto da obra exegética do autor, apresenta sua estrutura e explana sua interpretação do texto em análise. Por fim, sistematiza os principais dados recolhidos da análise feita.Abstract: This paper focuses on the analysis of Jerome's commentary on chapter 11 of Hosea. It intends to identify the applied exegetical procedure, understanding it in its structuring lines, its bases, and corollaries. To do so, it places the commentary on Hosea in the body of the author's exegetical work, presents its structure, and explains its interpretation of that text under analysis. Finally, it systematizes the main data collected from the analysis performed.
REVELAÇÃO, MISSÃO E INTERCULTURALIDADE: UMA ABORDAGEM A PARTIR DA PRETENSÃO UNIVERSAL DO CRISTIANISMO
Authors: Gonçalves Alonso
Published: October 2022

O artigo procura discutir a ambiguidade entre a validade de uma expressão religiosa, no caso aqui, mais especificamente, a indígena, e, ao mesmo tempo, a narrativa de aproximação a partir da inculturação. Com isso, pretendemos demonstrar que o uso do termo/conceito “inculturação” como principal ferramenta de abordagem missionária, carrega uma certa ambiguidade quando se admite o lugar de fala de expressões religiosas, mas ainda assim trata a cultura e a religião do outro com certas carências. Isso se dá de uma via apenas, uma vez que expressões religiosas como as indígenas, não carregam o mesmo modus operandi missionário por não terem essa incumbência, mas também por não possuírem uma religião de característica hegemônica, como é o cristianismo. Uma vez admitindo a manifestação revelacional nas demais expressões religiosas de maneira paritária e não ambivalente, a inculturação teria algumas dificuldades narrativas para fazer essa aproximação com o cristianismo e religiosidade indígena. Assim, entendemos que a interculturalidade seria um caminho para tal aproximação por favorecer meios teórico-narrativos por conter alguns elementos equitativos, não comparativos, mas também não acríticos, quando em uma perspectiva que leve em consideração a revelação em projeto teológico-missionário.Palavras-chave: Inculturação. Interculturalidade. Revelação. Missão. Indígenas.
Estudos sobre Karl Barth e teologia pública
Authors: Zeferino Jefferson
Published: October 2022

Karl Barth (1886-1968) foi um dos mais destacados teólogos do século XX. Sua vasta obra tem sido revisitada por diversos olhares. A teologia pública, nomenclatura que começa a ser utilizada em meados da década de 1970, e ainda em desenvolvimento, oferece espaço para uma releitura de complexos teológicos de outrora. No Brasil, as relações entre teologia e espaço público, bem como a demanda por um discurso público da teologia no âmbito acadêmico, são características que marcam as pesquisas recentes na área. Neste texto, por meio de uma análise bibliográfica, analisam-se diferentes propostas de relação entre Karl Barth e teologia pública, o que resulta na percepção tanto de uma pluralidade de formas de desenvolver essa conexão, quanto de compreensões sobre aquilo que se denomina de teologia pública. Abordar a relevante atuação histórica do teólogo de Basileia, lê-lo como um clássico, ou ainda a emergência de uma tradução pública de elementos ligados à sua base cristocêntrica são modos de atualização do legado teológico barthiano.
POR UMA REFORMA DO PAPADO: HISTÓRIA, APELOS E CAMINHOS À LUZ DO PONTIFICADO DO PAPA FRANCISCO
Authors: Souza Ney de , Da Silva Dias Tiago Cosmo
Published: October 2022

Desde que o Papa Francisco subiu a Sé de Pedro, em março de 2013, muito tem se falado, na Igreja, de reformas em todos os âmbitos. A finalidade deste artigo é refletir acerca da urgência da reforma do papado, resgatando os elementos históricos que favorecem os dogmas da infalibilidade e do primado e, ao mesmo tempo, revisitando os apelos dos papas às mudanças, procurando apontar alguns caminhos por onde a reforma pudesse transcorrer.
A tecnologia: criatividade e poder Uma reflexão ético-social à luz da Laudato si’
Authors: GOMES ROGERIO
Published: October 2022

O artigo visa refletir sobre o pensamento do Papa Francisco acerca da técnica, no capítulo terceiro da encíclica Laudato si’. Para isso, o autor apresenta a visão de alguns documentos do Vaticano II e de algumas encíclicas sociais para demonstrar como este assunto é compreendido pela Igreja que reconhece os benefícios do e as ambivalências do progresso tecnocientífico. É dessas bases que o Papa reflete, no âmbito da casa comum, sobre os benefícios da tecnologia como facilitadora da vida humana, o paradigma tecnocrático e o reducionismo antropológico e suas consequências. A reflexão considera o conceito de desenvolvimento na óptica da Doutrina social da Igreja. Desses elementos, o artigo busca aprofundar esse discurso a partir de algumas chaves de leituras que advém do próprio mundo da técnica e como isso interfere na vida humana.Palavras-chaves: técnica, paradigma tecnocrático, imperativo técnico, horizonte antropológico, poder, ambivalência.
A renovação da "Igreja em saída" e suas contribuições para o ecumenismo
Authors: Wolff Elias
Published: October 2022

O papa Francisco entende que a igreja necessita de mudanças, renovação e reformas que possibilitem “a saída” de si mesma para ir ao encontro do “outro” social, cultural e religioso. A “igreja em saída” precisa, então, superar elementos e situações que dificultam o cumprimento da sua missão de anunciar o Evangelho ao mundo atual, o que exige corajoso e profético redimensionamento teológico-pastoral que tenha incidência nas suas estruturas organizacionais. Essa proposta pode ser um importante impulso para o ecumenismo na medida em que “saída” seja um processo de “conversão pastoral” e de “estado permanente de missão” para as diferentes tradições eclesiais. Cada uma precisa “primeirear” nas mudanças internas que favorecem o encontro e a cooperação mútua no testemunho comum do Evangelho.
Propor a fé na pós-modernidade
Authors: De Mori Geraldo Luiz
Published: October 2022

Cada geração cristã é chamada a propor a fé no tempo e no espaço em que se encontra. Para isso, ela deve saber dar as “razões da própria esperança aos que lhe pedirem” (1Pd 3,15). Nas últimas décadas, o trabalho de “justificação da fé” tem se defrontado com as questões suscitadas pela assim chamada cultura pós ou hiper-moderna. O estudo aqui proposto mostra, na primeira parte, como a Igreja tem entendido essa cultura, indicando, na segunda parte, os caminhos que ela tem seguido para propor a fé em tempos pós-modernos, além de apontar pistas que podem iluminá-la nessa missão.
recepción del Concilio Vaticano II en América Latina La mirada de un biblista
Authors: La Serna Eduardo de
Published: October 2022

el Concilio Vaticano II gozó de una importante recepción en América Latina. La aceptación de la Constitución Dei Verbum se manifiesta claramente en diferentes aspectos como la proliferación de biblias, académicas o pastorales, de medios para su conocimiento, la lectura popular de la Biblia entre otras expresiones. Ninguna de estas ocurrió sin dificultades, algunas muy graves. Y el invierno eclesial, comenzado en los finales del pontificado de Pablo VI y que aún no ha finalizado, se manifiesta, también, en un intento de domesticación de la Biblia. Es tarea indispensable evitarlo para que con un oído en la Biblia y otro en el pueblo descubramos el proyecto de Dios para nuestra historia.
Gaudium et Spes: uma construção em processo
Authors: Toneti Edson Donizete
Published: October 2022

Revisitar a Gaudium et spes é oportunizar à Igreja um discernimento, sob a direção do Espírito, de dar testemunho da verdade, servir e não ser servida. No seio de uma sociedade multicultural, o presente artigo enfatiza a necessidade de formar um juízo sobre os “sinais dos tempos”, a partir de um exercício dialógico e de uma solidariedade intelectual. Num processo de continuidade com a tradição passada, o cuidado do bem comum demanda uma constante construção, no qual a mútua aprendizagem é salutar para lidar com as ambiguidades e manter uma postura fundamental da fé.
Pathogenetic significance of transforming growth factor β1 in patients with colorectal cancer
Authors: Chetveryakov A. V. , Tsepelev V. L.
Published: October 2022

Aim. We aimed to evaluate levels of transforming growth factor β1 (TGF-β1) in the serum, lymph nodes, and primary tumour in patients with colorectal cancer.Materials and Methods. Here we enrolled 44 patients with colorectal cancer and 25 patients with benign tumours of the colon admitted to Chita Regional Cancer Centre in 2019-2020. The control group included 25 patients with colon injury. The concentration of TGF-β1 in the serum, lymph nodes, and tumour homogenate was measured by flow cytometry (CytoFlex LX analyzer and LEGENDplex HU multiplex analysis kit).Results. Serum level of TGF-β1 in patients with colorectal cancer was 1.58-fold lower than in those with benign colon tumours and 1.38-fold lower than in the control group. In contrast, TGF-β1 level in tumor tissue was 5.91 (3.86; 7.81) fold higher than in the injured colonic tissue from the control group, although there were no statistically significant differences between the cancerous tissue and benign neoplasms.Conclusion. TGF-β1 is increased in tumour tissue but reduced in the serum of patients with colorectal cancer.
Antioxidants in treatment of kraurosis vulvae
Authors: Kiseleva E. A. , Makhmutkhodzhaev A. Sh. , Mikheenko G. A.
Published: October 2022

Aim. To study impact of ethylmethylhydroxypyridine succinate, an antioxidant, on the efficacy of photodynamic therapy (PDT) of kraurosis vulvae (vulvar lichen sclerosus).Materials and Methods. The study enrolled 90 patients with kraurosis vulvae who were randomised into 3 groups receiving: 1) PDT and ethylmethylhydroxypyridine succinate 1 week after the start of the PDT for 1 month; 2) PDT without ethylmethylhydroxypyridine succinate; 3) low-level laser therapy on the perineal region. Clinical manifestations of kraurosis vulvae were dynamically assessed before the treatment and 1, 6, and 12 months post treatment. The severity of vulvar itching was evaluated using visual analogue scale. LS-A index was calculated to determine the disease activity, whilst LS-S index was applied to quantify the affected vulvar area.Results. PDT demonstrated higher therapeutic efficacy in treatment of kraurosis vulvae than low-level laser therapy. Addition of ethylmethylhydroxypyridine succinate to the treatment protocol improved the results of PDT, as remission of vulvar itching within 12 months was achieved in 73% of patients who received PDT in conjunction with ethylmethylhydroxypyridine succinate and only in 47% of participants receiving PDT alone (p = 0.042). One month post treatment, the intensity of itching according to visual analogue scale was 2.0 points in patients who received combined treatment and 4.5 points in those receiving PDT alone (p < 0.001). Vulvar epithelialization also occurred earlier in patients receiving combined treatment (48 ± 5 days versus 54 ± 3 days in those receiving PDT alone, p < 0.001). Upon 12 months of observation, disease activity and affected vulvar area were significantly lower in patients receiving combined treatment (LS-A 4.0; LS-S 1.0) as compared to the PDT alone (LS-A 6.5; LS-S 3.0, p = 0.004 and < 0.001, respectively).Conclusion. Addition of ethylmethylhydroxypyridine succinate to photodynamic therapy demonstrated high efficacy against kraurosis vulvae and can be recommended for its treatment.
Immunosuppressive drugs and their aerosol delivery for COVID-19 treatment
Authors: Kobylyansky V. I.
Published: October 2022

Despite numerous efforts of healthcare, the incidence of COVID-19 and its fatal complications remains unacceptably high. As COVID-19 pathophysiology is notable for an uncurbed immune response, its treatment protocols routinely include immunosuppressive drugs such as corticosteroids, cytostatic drugs, calcineurin inhibitors, and monoclonal antibodies. Here we review the efficacy of the latter 3 drug classes, in particular inhalation preparations, in COVID-19 treatment and SARSCoV-2 elimination as well as their potential advantages and drawbacks. Efficacy of cytostatic drugs and calcineurin inhibitors in the treatment of airway inflammation in COVID-19 remains unconfirmed. Promising agents in this regard are biologics, including monoclonal antibodies and purinergic agents.
THE ART OF ARCHITECTURE: MEIER’S TIMELESS STYLE
Authors:   Tianjin University, Mujahed Layla
Published: October 2022

Introduction: An architectural identity is based on lasting architectural designs. Those common features that repeat across the architect’s designs determine the architect’s style and philosophy. Purpose of the study: We aimed to explore the style and philosophy of Richard Meier by studying his building designs developed in different time periods. Methods: In the course of the study, we used a mixed-method approach that includes the quantitative and qualitative research methods. By using the quantitative research method, we focused on the five selected cases of Meier’s buildings differing in location, typology, and year of construction. The qualitative research method involved the observation method. Results: It was established that the main features of Meier’s style are the abstract white geometric form, circular structural columns, floor-to-ceiling glass walls, interior double-volume spaces, long circulation axis, and skylights. Richard Meier used the philosophy of combining lightness, placeness, and simplicity to make his vision a reality.
MODERN MATERIALS AND STRUCTURES USED IN HOUSING CONSTRUCTION: INTERNATIONAL EXPERIENCE
Authors:   Saint Petersburg State University of Architecture and Civil Engineering, Pastukh Olga , Mähner Dietmar ,   Münster University of Applied Sciences, Panin Aleksandr ,   Saint Petersburg State University of Architecture and Civil Engineering, Elistratov Vladimir ,   Saint Petersburg State University of Architecture and Civil Engineering
Published: October 2022

Introduction: The article addresses the possibility of using universal energy-efficient engineering and technological solutions in mass housing construction, regardless of the climatic region of construction, with account for modern development in Saint Petersburg (Russian Federation) and Münster (Germany). The article not only considers improvements in building technologies used in modern housing construction but also offers an overview of the latest energy-efficient materials and structures. Purpose of the study: We aimed to introduce energy-efficient solutions in housing construction using innovative technologies and materials. In addition to theoretical materials, practical calculations will be presented, clearly showing the advantages and disadvantages of various engineering and technical solutions. Methods: In the course of the study, we used a) a comparative analysis of physical and thermal properties as well as strength characteristics of building materials used in mass housing construction; b) a problem-logical method to analyze possible typical space-planning and structural solutions for the design and construction of buildings, with account for climatic conditions and geographical features of the construction region, in compliance with the basic principles of modern sustainable construction, energy and environmental standards, economic efficiency of the solutions used, in accordance with international European LEED and BREEAM and Russian GREEN ZOOM standards. Results: We propose to introduce, along with the already well-known and time-tested ones, innovative patented solutions in materials and construction technologies both in private and mass housing construction in the countries under consideration: Russian Federation and Germany. Discussion: The discussion of field tests and implementation of the latest building materials in housing construction clearly demonstrates the importance of international cooperation in this field at various levels. As a consequence of the growing volume of housing construction and energy consumption, there emerge new stricter requirements and standards for the quality of materials produced and their technical characteristics, as well as a variety of decorative solutions enabling the construction market to be competitive and meet the over-demand requirements of the rapidly developing industrial society, while necessarily taking environmental protection measures, including those on conservation and mindful use of natural resources.
Identifying Climate Change Impacts On Hydrological Behavior On Large-Scale With Machine Learning Algorithms
Authors: Ivanov Aleksander M. , Gorbarenko Artem V. , Kireeva Maria B. , Povalishnikova Elena S.
Published: October 2022

The article presents the results of study of the application of machine learning methods to the problem of classification and identification of different river water regimes in a large region – the European territory of Russia. An accumulation of hydrological observation data for the 60 – 80 years makes it possible to create an information basis for such studies. The article uses information on the average monthly runoff at 351 hydrological gauges during the period from 1945 to 2018. The most widely used data clustering approaches were used as analysis methods – K-means, EM-method, agglomerative hierarchical clustering, DBSCAN algorithms and the application of gradient boosting methods (CATBUST). Clustering and classification algorithms were given eight parameters as a basis for prediction. It was found that the most distinct and stable clusters are formed with three parameters, and the highest silhouette coefficient (SS = 0,3-0,5) is obtained using the numbers for months of the maximum and minimum runoff and the ratio of the maximum to the minimum water flow. The best result gives DBSCAN (SS = 0,6 – 0,7). Supervised classification models also show high correspondence with the reference classification, with an accuracy of 87%. Both clustering methods and classification methods showed a shift of clusters representing southern water regimes. In the central region these regimes expanded by a 1000 km to the north. Furthermore, results demonstrate that currently available data already makes it possible to apply machine learning methods to the analysis of hydrological data. Clusters corresponding to different types of water regime can be obtained by utilizing contemporary clustering algorithms. The study shows that over the past 40 years, the southern types of water regimes have noticeably shifted to the north.
PREPARING FOR NEW LEARNING: PUBLIC VOCATIONAL HIGH SCHOOL STUDENTS’ AND TEACHERS’ E-LEARNING READINESS SINGARAJA IN THE EFL INSTRUCTION
Authors: Aryani Made Ayu Bintang , Santosa Made Hery , Dambayana Putu Eka
Published: October 2022

This study aimed to find out 1) the e-learning readiness level of students and teachers in Public Vocational High School Singaraja and 2) factors affecting teachers’ and students’ e-learning readiness level of Public Vocational High School Singaraja. It designed using mixed method through survey instrument consists of 3 dimensions (e-learning readiness, e-learning acceptance, e-learning training) and interview guide. The instruments validated by the experts and gained 0.666 from 70 students’ sample and 0.231 from 7 teachers’ sample. The reliability was 0.988 0.666 of 35 items and 0.933 0.231 of 38 items. The survey filled by 410 students and 15 English teachers meanwhile the interview answered by 10 students and 5 English teachers. The questionnaires showed they still need few improvements meanwhile interview results shown their e-learning readiness affected by features, benefits, challenges, familiarity, experience and personal innovativeness. Those results showing that e-learning benefits improve their readiness meanwhile e-learning challenges could lower the users’ readiness. It is considered to improve their readiness by reducing e-learning challenges to create comfortable e-learning access.
SEVERAL ASPECTS OF IMPRINTING IN THE FORMATION OF COGNITIVE IMPAIRMENTS IN CHILDREN OF DIFFERENT AGES
Authors:   Siberian State Medical University (SSMU), Tomsk, Russia, Matveeva M.V. , Samoilova Yu.G. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Kudlay D.A. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia,   National Research Center Institute of Immunology of the Russian Federal Biomedical Agency, Moscow, Russia, Galyukova D.E. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Oleinik O.A. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Trifonova E.I. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Yun V.E. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Vachadze T.D. ,   Siberian State Medical University (SSMU), Tomsk, Russia
Published: October 2022

Understanding of the processes that underlie brain development is of great clinical importance because it helps determining endo- and exogenous factors that may influence the neurocognitive abilities of human progeny. It is known that cognitive functions of children largely depend on the prenatal and intrauterine environment, which denotes that programming of future health occurs even before the birth of a fetus. This bibliographical review considers some environmental factors, such as neurohormonal, alimentary, and somatic, that influence the formation of the concept of metabolic imprinting, which in its turn allows determining the main risk groups and directions for therapeutic and preventive measures with the purpose of formation of mother's health for future healthy progeny, including the cognitive functions. The following databases were studied thoroughly in this review: PubMed®, Wiley Online Library, and eLIBRARY; the sources dated 2000 to 2021 were used.
PRIMARY HYPERPARATHYROIDISM CAUSED BY THE PARATHYROID ADENOMA ECTOPIC IN THE THYMUS: A CLINICAL CASE
Authors:   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Uskova N.G. , Babaskina N.V. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Il’ina E.Yu. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Abramov D.S. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Kurnikova M.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Akhaladze D.G. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Grachev N.S. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
Published: October 2022

Primary hyperparathyroidism (or PHPT) is a rare pediatric disease occurring in 1 case per 200 to 300 thousand children. The most common cause of PHPT in the adult population is a solitary parathyroid (PT) adenoma with up to 16% of PT adenomas having an ectopic location. There are no epidemiological data on pancreatic adenomas in pediatric population including atypically located ones, and clinical data are extremely scarce. This article describes a clinical observation of an adolescent patient with PHPT whose disease has been manifested with increased fragility and deformation of the bones of the skeleton. Only one year after the onset of primary symptoms a complex set of diagnostic measures was initiated, as a result of which a diagnosis was established: PHPT against the background of adenoma of the pancreas, ectopic in the left lobe of the thymus. The surgical treatment was carried out in the amount of thoracoscopic hemithymectomy which led to the relief of hyperparathyroidism. Despite the surgical intervention the systemic osteoporosis and persistent pathological changes in the bone skeleton that have been formed by the time of diagnosis require long-term observation and treatment of the patient by a pediatric endocrinologist, pediatric orthopedist and rehabilitologist. Thus, based on the presented clinical observation, the conclusion is as follows: in order to minimize the risk of disability in children and adolescents with PHPT it is extremely important to establish the correct diagnosis as early as possible coupled with the timely etiotropic and pathogenetic treatment.
EARLY DIAGNOSIS OF CAMURATI–ENGELMANN DISEASE, ALSO KNOWN AS PROGRESSIVE DIAPHYSEAL DYSPLASIA: DETECTION OF A CAUSATIVE MUTATION BY WHOLE GENOME SEQUENCING
Authors:   EVOGEN-GENOME Clinical Genetic Laboratory, LLC, Moscow, Russia, Kokorina O.S. , Sagaydak O.V. ,   EVOGEN-GENOME Clinical Genetic Laboratory, LLC, Moscow, Russia, Baranova E.E. ,   EVOGEN-GENOME Clinical Genetic Laboratory, LLC, Moscow, Russia,   Russian Medical Academy for Continuous Professional Education, Moscow, Russia, Zobkova G.Yu. ,   EVOGEN-GENOME Clinical Genetic Laboratory, LLC, Moscow, Russia, Belenikin M.S. ,   EVOGEN-GENOME Clinical Genetic Laboratory, LLC, Moscow, Russia, Groznova O.S. ,   Research and Clinical Institute of Pediatrics named after Academician Yuri Veltischev with the Pirogov Russian National Research Medical University, Moscow, Russia,   Charity Fund Life Genome, NPO, Moscow, Russia, Melikyan L.P. ,   Research and Clinical Institute of Pediatrics named after Academician Yuri Veltischev with the Pirogov Russian National Research Medical University, Moscow, Russia,   Charity Fund Life Genome, NPO, Moscow, Russia, Shidlovskaya O.A. ,   Research and Clinical Institute of Pediatrics named after Academician Yuri Veltischev with the Pirogov Russian National Research Medical University, Moscow, Russia
Published: October 2022

A description of a patient with a rare form of Camurati-Engelmann Disease (CED), also known as progressive diaphyseal dysplasia, manifested by gait disturbance, pain in the limbs and muscle weakness is presented. It is only ca. 300+ patients with this disease have been described worldwide to date. It was discovered in various ethnic groups regardless of gender. A clinical case observation of this disease with molecular genetic confirmation of the diagnosis is presented for the first time in a Russian language scientific periodical. Establishing an accurate diagnosis in the described observation became possible only thanks to the use of a modern molecular genetic method, Next-generation sequencing (NGS). The clinical case observed in the article showed non-specificity of symptoms in this disease. It would be impossible to establish an accurate diagnosis without the use of top notch, modern genetic technologies in this case. The absence of specific symptoms coupled with the late manifestation of the disease suggest that not all of the cases of this disease are detected and diagnosed.
Stock Plant Management of Lavandula angustifolia ‘Wee One' Using Plant Growth Regulators
Authors: Schriner Lauryn , Klett James E.
Published: October 2022

Lavandula angustifolia ‘Wee One' is a drought-tolerant perennial being used in landscapes throughout the western United States. Increased demand has resulted in problems with stock plant management and propagation due to the relatively small and slow vegetative growth. The objective was to determine if gibberellic acid, benzyladenine, ethephon, or auxin [indole-3-butyric acid (IBA)] plant growth regulators (PGR) applied as a foliar spray on Wee One lavender plants could be used to increase the number of cuttings for production. Fifteen replications of Wee One Lavender were evaluated for four months for plant height, width, number of cuttings, and fresh and dry weight of the cuttings. This study was replicated twice, the first experiment was performed from March 2020 to July 2020 and the second experiment from August 2020 to December 2020. A secondary propagation study was conducted simultaneously to check if PGR residuals effected rooting. The use of different PGRs caused an increase of cuttings from stock plants throughout both experiments. Foliar applications of gibberellin (ProGibb T&O) at 100 mg·L−1 (ppm) increased stem length and branching in one experiment, resulting in a higher number of cuttings produced compared to nontreated control stock plants, although that effect was not seen in the other conducted study. In one study, ProGibb T&O application did not negatively impact the rooting of individual cuttings, while it did so in the other study.

Species used in this study: Wee One lavender [Lavandula angustifolia Mill].

Chemicals used in this study: gibberellic acid (GA3), ethephon, indole-3-butyric acid(IBA), N-(phenylmethyl)-IH-purine 6-amine (BA).
«I am never done!» Homeland: Is Carrie Mathison a Convincing Example of Political Sustainability and Political Efficiency?
Authors: Baer Josette
Published: October 2022

In this paper, I focus on CIA agent Carrie Mathison of the US TV series Homeland. The blond, young and very intelligent CIA analyst is a splendid example of sustainability and efficiency in politics. Scrutinizing series 1 and series 8, hence the first and last series, I demonstrate how Mathison’s activities and decisions are sustainable and effective for her employer, the CIA. Naturally, Homeland is fiction, but fiction can inspire political theorists to think about politics. Were not all contract theories fiction? Were not the utopiae of Morus, Campanella and Cavendish fiction that taught the readers how to think about the political possibilities with regard to governmental rule, constitutional issues and women’s rights in society? Carrie Mathison is mentally handicapped with bipolar syndrome, but that makes her a great agent; hyper-sensible and sensitive, she sees what everybody else overlooks, and her mild paranoia is effective in detecting traitors and agents turned by foreign secret services. Carrie Mathison is one of the most interesting persona in recent US TV fiction. Is she a Machiavellian character?
A comparison of SureSmileTM, InsigniaTM, and InvisalignTM, in treating non-extraction cases of mild to moderate crowding: a prospective clinical trial
Authors: Kim Edward , Sherf Niloufar , Lamichane Manish , Levine Sam , Allareddy Veerasathpurush , Ellenikiotis Yianni , Koch George K. , Masoud Mohamed I.
Published: October 2022

Objectives: To compare the ability of SureSmileTM, InsigniaTM and InvisalignTM to achieve predicted intra-arch tooth positions and further compare their objective grading scores for alignment/rotations, marginal ridge relationships and buccolingual inclination.

Materials and methods: The study was a prospective clinical trial of 145 arches from 44 females and 29 males (54 SureSmileTM arches, 35 InsigniaTM arches, and 56 InvisalignTM arches). All arches were treated by a non-extraction approach and had ≤7 mm of crowding and 45° of tooth rotation. The manufacturer’s recommendations were followed for each group and the final scans were acquired before refinements, rebonding, or wire bending. The virtual set-ups were superimposed on the final scans and the coordinates of 34 landmarks per arch were compared. One hundred and twenty-six end-of-participation arches were suitable for 3D printing and were compared using the American Board of Orthodontics Objective Grading Scores (OGS) for alignment/ rotations, marginal ridge relationships, and buccolingual inclination.

Results: No statistically significant differences were identified in the mean deviation between the target and achieved the position of the anterior landmarks within the treatment groups. The exception was the Suresmile group which had greater vertical discrepancies in the position of the labial CEJ. Although the mean differences between the target and achieved anterior landmark positions for all groups were under 0.5 mm, the range of maximum discrepancy was between 0.7 mm and 4.1 mm. The InsigniaTM system showed significantly greater deviation in upper posterior landmark positions in the transverse and sagittal dimensions, and lower posterior landmarks in the transverse dimension. However, this was due to the InsigniaTM initial set-ups being wider. There was no statistically significant difference between the three systems in combined intra-arch OGS. However, the InvisalignTM system had a significantly poorer alignment/rotation score than the SureSmileTM group. The InsigniaTM system performed better in achieving buccolingual tooth inclination compared to SuresmileTM, and the InvisalignTM system performed better than the SuresmileTM system in the marginal ridge score.

Conclusions: The three systems were comparable in achieving the predicted tooth positions of the anterior teeth in non-extraction, mild-to-moderate, crowded cases. Large discrepancies requiring operator intervention were common within the three systems. Although the three systems had no statistically significant difference in overall intra-arch OGS scores, there were significant differences in the score components.
Effectiveness of pulmonary rehabilitation performed through exercise training for patients with stable COPD: A meta-analysis of randomized controlled trials
Authors: Zerbo Šporin Dorjana , Domjanič David , Žvanut Boštjan
Published: October 2022

Background

The application of pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) improves functional capacity and health-related quality of life (HRQoL) at all stages of disease severity. The aim of this study was to determine the effects of PR, performed through exercise training (PR-ET), on functional capacity and HRQoL in patients with stable COPD.

Methods

The meta-analysis was performed by including randomized controlled trials (RCTs) involving patients with stable COPD who participated in different types of PR-ET in which six-minute walk distance (6MWD) and/ or St. George’s Respiratory Questionnaire total scores (SGRQ) were measured. The data search was conducted in December 2020 and January 2021.

Results

The first meta-analysis showed a statistically significant positive effect (MD=31.73m; p<0.00001) of PR-ET on 6MWD. Similarly, the second meta-analysis found a statistically significant favourable effect of pulmonary rehabilitation through exercise training on SGRQ total scores (MD=-8.09; p=0.002).

Conclusions

PR, which includes several different types of exercise training, has a positive effect on the functional capacity and HRQoL of patients with stable COPD. Further studies should be conducted to determine the effects of home-based PR-ET and PR-ET >8 weeks on SGRQ total scores.
Mandatory extraction payment disclosures and tax haven use: Evidence from United Kingdom
Authors: Kobbi-Fakhfakh Sameh , Driss Fatma
Published: October 2022

Research Question: Does public country by country reporting (CbCr) deter multinationals' tax avoidance practices operating in extractive industries? Motivation: Public CbCr has already been implemented for two specific sectors, namely the financial and extractive sectors. Prior studies have focused on tax avoidance of EU banks around the implementation of public CbCr requirement (Joshi et al., 2020; Eberhartinger et al., 2020; Overesch & Wolff, 2021). However, studies on how resource-extracting multinationals respond to the CbCr regulation are scarce. This study seeks to fill this gap by examining the effect of public CbCr on tax avoidance with a special focus on extractive industries. Idea: To improve fiscal transparency, Canadian and European legislators have adopted regulations requiring multinational corporations (MNCs) to provide, annually, their Extraction Payment Disclosures (EPD) (Public CbCr standard for extractive industries) to governments (EC, 2013; Natural Resource Canada, 2014). This study examines the effect of mandatory EPD adoption on the extent of tax haven use. Data: For a 10-year period surrounding the mandatory EPD adoption (2010-2019), we selected a sample of UK MNCs operating in the oil, gas, and mining sectors and listed on the London Stock Exchange. The analysis is mainly based on firm-level information taken from DATASTREAM database. Based on hand-collected data from annual reports, we measured the extent of tax haven use using the percentage of multinational subsidiaries located in tax haven jurisdictions/countries as listed in Dyreng and Lindsey (2009). An alternative list identified by the Organization for Economic Co-operation and Development (OECD) (2006) was also used in a robustness test. Tools: To examine our research question, we estimated a linear regression model with panel data using STATA software. Findings: The results show that the increased transparency resulting from public EPD does not appear to significantly affect the intensity of tax haven use. Contribution: This study extends and complements prior literature examining the effect of CbCr on tax avoidance and profit shifting by focusing on a specific setting i.e. extractive sector. To the best of our knowledge, apart from Johannesen and Larsen (2016) and Rauter (2020), no studies have provided empirical evidence on how resource-extracting multinationals respond to the EPD regulation.
Information support as a basis models for managing transaction costs of marketing activities of a manufacturing enterprise
Authors: Starukhin Vitalii Anatolyevich
Published: October 2022

The purpose of the study is to formalize the stages of managing transaction costs of marketing activities of a manufacturing enterprise based on information about their amount in the parameters of the contract. The scientific novelty of the research lies in the fact that the paper proposes the progressive stages of the process of forming initial data for managing the transaction costs of marketing activities; the grouping of transaction costs for marketing at the pre-contract, contract and post-contract stages with their details depending on the volume of sales and independent of it is proposed; the stages of managing transaction costs of marketing activities of a manufacturing enterprise are recommended, focused on analyzing forecast information taking into account a variety of assumptions and assessing the variability of the environment within the framework of the contract. As a result, it was established that the management of transaction costs of marketing activities of a manufacturing enterprise should be carried out by management continuously by analyzing information structured for each commercial transaction, which allows management to constantly and discretely possess information on each contract. At the same time, the financing of the transaction cost management process should not constitute a significant part of the business expenses of the organization. The use of the management information support proposed by the author for managing transaction costs in the implementation of marketing activities in practice allows a manufacturing enterprise to obtain forecast values of commercial expenses in relation to upcoming deliveries, to assess the economic effect of profitability indicators for them.
History of the mechanistic concept in western European philosophical thought
Authors: Berkovsky Vyacheslav Aleksandrovich , Tronina Larisa Anatolyevna , Goncharov Artyom Sergeevich
Published: October 2022

This study is devoted to the study of the stages of formation and development of the mechanistic concept in the history of Western European philosophy. The purpose of the study is a comprehensive analysis of the historical and historical-cultural periods of the development of the mechanistic concept, including Antiquity, the Hellenistic era, the Middle Ages, the Renaissance, the New Time and the Newest Time. Scientific novelty of the study is expressed in a new look at the problem of perception of the philosophy of mechanism by foreign and Russian researchers. To obtain the most reliable data on the forms and types of mechanism within the popular concepts of European philosophers, we adhere to the analytical approach of B. Russell, believing that this particular approach is necessary to reveal the essence of mechanism at the level of linguistic consciousness. The result of the study was to obtain more accurate information about the evolution of mechanism and its connection with social facts in the history of European philosophical thought from the standpoint of the analytical tradition.
The concept of the "Other" in the historical and philosophical retrospective
Authors: Borisenko Nadezhda Nikolaevna
Published: October 2022

The purpose of the study is to iidentification of socio-philosophical interpretations of the concept "Other" in the works of philosophers of the XVIII-XX centuries. Scientific novelty. A comparative analysis of the understanding of the "Other" in the philosophical research of G.V.F. Hegel, M. Heidegger, E. Husserl, J.-P. Sartre, S. Frank, M. Bakhtin, M, Merleau-Ponty, M. Buber, E. Levinas, J. Derrida, J. Deleuze, A. Schutz, and also reveals the essential characteristics of the "Other" in he philosophical works of each author, and also defines the conceptual approaches to the "Other" in the philosophy of existentialism and phenomenology. As a result, it is concluded that the "Other" is one of the central categories of social philosophy, mainly in the 19th-20th centuries, however, since the time of Aristotle, philosophers have been interested in the analysis of otherness.
The concept of creativity and innovation - modern philosophical analysis
Authors: Zolotarev Sergey Petrovich
Published: October 2022

The purpose of the study is to consider the parameters of creativity and innovation. Several types and forms of relationships between these categories have been established, from the standpoint of axiology and opposition to creativity and simulation. Theories are used that determine the dialectical connection of the studied categories. Emphasis is placed on the peculiarity of the co-evolutionary type of creativity as the formation of a special type of worldview in modern society. The scientific novelty lies in the fact that a methodologist-theoretical analysis of the relationship between man and the environment was carried out on the basis of his creative activity. A new type of understanding by the individual of the social environment as an axiological abstraction and its simulation is applied. Based on the method of dialectics and empirical analysis, a new study of the features of the modern development of society is proposed. The result of the study was the conclusion that the understanding of creativity and innovation should be considered from the standpoint of the ontological relationship of the worldview, creative and co-evolutionary type of creativity. A new way of considering the two opposites of creativity and its simulation based on axiological theory is proposed. The necessity of studying creativity and innovation as one of the methods of forming a modern type of worldview and creative initiative of a person in connection with the ongoing confrontation between Russia and NATO countries, and the special operation on demilitarization and denazification of Ukraine is shown.
Positioning pictures of the world order within the framework of transhumanism by heuristic methods
Authors: Alferev Dmitry Aleksandrovich
Published: October 2022

Accurate positioning of the current state of worldview perception allows you to more effectively and pragmatically carry out your activities. In connection with the active development of various technologies in the world, new views on the current world order have been formed, designated as transhumanism. In accordance with this, the purpose of the article is to identify the position of a new picture of the world in relation to its other analogues. As a result, the paper presents an overview of the basic concepts of world order that have existed up to the present time. By means of the heuristic method of pairwise comparisons, the numerical and graphical positioning of transhumanism is implemented in comparison with earlier ideas about the world. Scientific novelty is represented by the obtained comparison of world order, where their advantages in the formation and adoption of new value human attitudes were identified.
Forgiveness as a meeting and as a farewell: philosophical and anthropological analysis
Authors: Makarenko Maria Vitalievna
Published: October 2022

Due to the way people, culture, value orientations of the current generation are changing, the moral and moral grounds for the formation of a socio-cultural background, the purpose of the study is to study the need to preserve traditional humanistic values in the information society era. At the same time, the main categories of ethics (following society) are undergoing global transformations. As a consequence, the result of the work is the assumption of the need to recognize the importance of traditional moral and moral pillars of personality development, in particular the importance of forgiveness as one of the markers of moral education of a person for the possible preservation of individual selfhood, since it is in the process of communication that a person is able to discover his true nature, or essence, thanks to the opportunity to make a moral choice between forgiveness or by unforgiveness, thus revealing oneself to the present for the other or in relation to the other.
Spiritual virtues as a factor of Human transformation in Russian Cosmism
Authors: Makeeva Oksana Evgenievna
Published: October 2022

A person whose spiritual virtues are capable of changing the world is the center of the transformation of reality according to the teachings of cosmism. Christianity also places a person at the center of the Universe, who must prepare his whole life to stay in the kingdom of the Spirit. The article is devoted to both general trends in Christianity and cosmism, as well as fundamental differences between religion and philosophy, which have the same spiritual basis. The purpose of the study is to identify the importance of moral values of a person based on spiritual development for his transformation and gaining the ability to influence the world around him. The article focuses on the essence of man, whose purpose is manifested in the development of his creative and transformative power, and the role of spiritual values in this comprehensive process. The scientific novelty lies in the philosophical understanding of the mission of man as a converter of reality with the support of Christian foundations.
Information wars: the clash of civilizational pessimism and civilizational optimism in social prognostics
Authors: Malinova Isabella Pavlovna
Published: October 2022

In the article, the author explores the methodological foundations of the forecasting of civilizational processes using modern material. On the basis of the code theory of the functioning of complex self-governing systems, a concept of synergistic approaches to stopping the factors of exacerbation of situations characteristic of information and economic wars has been developed. A critical analysis of the concepts of civilizational pessimism and their influence on civilizational processes on the scale of the planetary society has been carried out. On the basis of the theory of social logic of Gabriel Tarde, models of substantiation in the public consciousness of the concepts of civilizational optimism have been developed.