bluuebunny/crossref_metadata_2025 huggingface dataset:
Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking
Authors: Modica Graziana , Skorobogata Olga , Sauvageau Etienne , Vissa Adriano , Yip Christopher M. , Kim Peter K. , Wurtele Hugo , Lefrancois Stephane
Published: June 2017

Retromer is a multimeric protein complex that mediates endosome-to-trans-Golgi network (TGN) and endosome-to-plasma membrane trafficking of integral membrane proteins. Dysfunction of this complex has been linked to Alzheimer's disease and Parkinson's disease. The recruitment of retromer to endosomes is regulated by Rab7 (also known as RAB7A) to coordinate endosome-to-TGN trafficking of cargo receptor complexes. Rab7 is also required for the degradation of internalized integral membrane proteins, such as the epidermal growth factor receptor (EGFR). We found that Rab7 is palmitoylated and that this modification is not required for membrane anchoring. Palmitoylated Rab7 colocalizes efficiently with and has a higher propensity to interact with retromer than nonpalmitoylatable Rab7. Rescue of Rab7 knockout cells by expressing wild-type Rab7 restores efficient endosome-to-TGN trafficking, while rescue with nonpalmitoylatable Rab7 does not. Interestingly, Rab7 palmitoylation does not appear to be required for the degradation of EGFR or for its interaction with its effector, Rab-interacting lysosomal protein (RILP). Overall, our results indicate that Rab7 palmitoylation is required for the spatiotemporal recruitment of retromer and efficient endosome-to-TGN trafficking of the lysosomal sorting receptors.
Stent-Assisted Coil Embolization of Posttraumatic Dissecting Carotid Aneurysm Causing Ophthalmoplegia
Authors: Esen Kaan , Eriş Huseyin Naim , Yildiz Altan , Kara Engin , Ozgur Anil
Published: June 2017

Background: Ophthalmoplegia secondary to a traumatic dissecting aneurysm in the cavernous segment of internal carotid artery (ICA) is a relatively rare entity. Anticoagulant or antiplatelet therapy is the preferred treatment option for carotid dissections. However, endovascular interventions are noninvasive and alternative methods to surgery, especially in cases of aneurysms that do not respond to medical therapy.

Case Report: We report of a 19-year-old man presenting with left-sided, total ophthalmoplegia after a traffic accident. Magnetic resonance imaging (MRI) and digital subtraction angiography (DSA) revealed a dissection beginning at the cervical segment of internal carotid artery (ICA) together with a dissecting aneurysm in the cavernous segment. A stent was placed in the narrowed and dissected segment of ICA, and the dissecting aneurysm of the cavernous segment was successfully managed with a stent-assisted coil embolization. After the endovascular treatment of the aneurysm, a full recovery of cranial nerve function was achieved.

Conclusions: Immediate diagnosis and appropriate therapy of dissecting aneurysms is necessary for good clinical outcomes in cases of ophthalmoplegia.
Behaviour guidance with a sharp, no-nonsense edge
Authors: O'Connell Suzanne
Published: June 2017

Behaviour tsar Tom Bennett's guidance contains some strong messages about behaviour in our schools. It also promotes a hard line. Suzanne O'Connell considers its main messages and how they apply to primary schools
Ideas for the summer…
Authors: Aubrey-Smith Fiona
Published: June 2017

As the end of the year approaches, Fiona Aubrey-Smith speaks to headteachers from across the country who share a range of practical ideas to support pupil (and teacher) learning this summer term and into the school holidays
A library in every class
Authors: Donohoe Tom
Published: June 2017

With a small school library that was not fit-for-purpose, Tom Donohoe set about a new approach – creating a well-equipped mini-library in every single classroom…
Setting up a primary school nurture group
Authors: Corrigan Jo
Published: June 2017

Drawing on the work of South Rise Primary School, Jo Corrigan considers what makes nurture group provision successful, the impact it has on children and their families, and offers advice for schools
Latest clinical research
Authors: Greener Mark
Published: June 2017

Mark Greener presents key studies published in healthcare journals
Beginning statin therapy
Authors: Kochhar Suneeta
Published: June 2017

With correct assessment, statins are effective preventors of cardiovascular disease, writes Dr Suneeta Kochhar
Constipation: A guide to assessment and treatment
Authors: Nazarko Linda
Published: June 2017

Linda Nazarko examines the common causes and most effective treatments for a sensitive condition
Diabetes and visual problems
Authors: Nazarko Linda
Published: June 2017

With diabetes rates steadily rising, Linda Nazarko offers a guide to the damage it can cause to eyesight, as well as the best methods of detection and treatment

The number of people diagnosed as having diabetes mellitus (DM) has risen from 1.4 million to 3.59 million in the last 17 years and an estimated million people with DM are undiagnosed. Diabetes mellitus (DM) is the leading cause of preventable sight loss in adults of working age (16-64) in the UK ( Liew et al, 2014 ). People with DM are at increased risk of developing, cataracts, glaucoma, diabetic retinopathy and maculopathy ( Mukesh et al, 2006 : Newman-Casey et al, 2011 : Scanlon, 2008 ). As the number of people who have diabetes grows increasing numbers are at risk of developing visual problems. Early detection of diabetes, managing diabetes well and avoiding damage caused by hyperglycaemia, and screening programmes can reduce the risk of sight loss in people with diabetes. The practice nurse can, by identifying people at risk of diabetes and supporting people with diabetes, reduce the risk of sight loss and make a huge difference to a person's quality of life. This article explains how diabetes increases the risk of visual problems, how risks can be reduced and how problems can be treated.
Treating seasonal allergic rhinitis in adolescents: case study
Authors: Batt Rebecca
Published: June 2017

Allergic rhinitis is an often ignored or misdiagnosed condition that can have a major effect on a teenager's quality of life. Rebecca Batt uses a specific case study to throw light on the immunological and therapeutic issues involved

Seasonal allergic rhinitis (SAR) is a common disorder affecting up to 20% of the population ( Scadding et al, 2008 ). Symptoms include nasal irritation, sneezing, itching, rhinorrhoea and nasal blockage, which may be intermittent or persistent. These symptoms may lead to sleep disturbance, which adversely affects quality of life (QOL) and learning ability, and can contribute to a drop in grades in examinations taken in the summer months. An accurate diagnosis and optimal management of SAR is essential to minimise the effects of this common allergic disease on the individual. Allergic rhinitis (AR) is often ignored, misdiagnosed and mistreated. Undertreated AR impairs quality of life, exacerbates asthma and is a major factor in the development of asthma ( Scadding, 2015 ). This clinical case will focus on a teenager with SAR, and the immunological implications and therapeutic management of this disease will be discussed.
Preparing for the summer
Authors: Knightsmith Pooky
Published: June 2017

A recent webinar hosted by mental health and wellbeing expert Dr Pooky Knightsmith focused on how we can help to prepare vulnerable children and young people for the school holidays….
Availability comparison between three dissimi-lar photovoltaic configurations
Authors: K Suleiman , Yusuf Ibrahim , Ali U.A. , Koko A. D , Bala Saminu I
Published: June 2017

The paper deals with availability comparison between three dissimilar photovoltaic configurations using Markov Birth-Death process and probabilistic approach. The configurations consist of four subsystems arranged in series-parallel with three possible states; working with full capacity, reduced capacity and failed. Through the transition diagrams, systems of differential equations are developed and solved recur-sively via probabilistic approach. Explicit expressions for steady-state availability are derived. Availability matrices for each subsystem have been developed to provide various performance values for different combinations of failure and repair rates of all subsystems. Furthermore, we compare the availability for the three configurations and find that configuration III is more reliable than system, I and II. The results have shown that the system availability increases with increase in redundant units. The results of this paper will enhance the system performance and useful for timely execution of proper maintenance improvement, decision, planning and optimization.
The amortization of vibrations on machines - case study
Authors: Latifi Ahmet , Abazi Arsim , Shartari Astrit
Published: June 2017

When determining the static rigidity of the machine, only loads of constant forces are taken into account. However, machine details are not loaded only with static forces but also with external and internal dynamic forces. Components of static forces affect the form errors, while dynamic instability, and as a result of dynamic forces have negative impact on: the severity of processed surface, the wear of the metal cut-ting tool, wear of the machine details and productivity.
Vieta’s formulae for regular polynomials of a quaternionic variable
Authors: Vlacci Fabio
Published: June 2017

Vieta’s classical formulae explicitly determine the coefficients of a polynomial p ∈ 𝔽[x] in terms of the roots of p, where 𝔽 is any commutative ring. In this paper, Vieta’s formulae are obtained for slice-regular polynomials over the noncommutative algebra of quaternions, by an argument which essentially relies on induction, without invoking quasideterminants or noncommutative symmetric functions.
Drapeable unit arcs fit in the unit 30° sector
Authors: Movshovich Yevgenya , Wetzel John E.
Published: June 2017

We show that a 30° circular sector of unit radius contains an isometric copy of every drapeable unit arc, and we describe the family of drapeable exit arcs of unit length in the sector. The conjecture that this sector is a cover for the family of all unit arcs remains unresolved.
On deformations of parallelG2structures and almost contact metric structures
Authors: Aktay Şirin
Published: June 2017

It is known that manifolds withG2structures have almost contact metric structures; see [3; 16]. In this manuscript, we deform a parallelG2structure by a parallel vector field and investigate the properties of the almost contact metric structure obtained by the deformation of theG2structure.
A fundamental theorem for submanifolds of multiproducts of real space forms
Authors: Lawn Marie-Amélie , Roth Julien
Published: June 2017

We prove a Bonnet theorem for isometric immersions of submanifolds into the products of an arbitrary number of simply connected real space forms. Then we prove the existence of associate families of minimal surfaces in such products. Finally, in the case of 𝕊2 × 𝕊2, we give a complex version of the main theorem in terms of the two canonical complex structures of 𝕊2 × 𝕊2.
Modified classical flat Minkowski planes
Authors: Steinke Günter F.
Published: June 2017

We construct anew family of flat Minkowski planes that admit the simple group PSL2
(ℝ) as a group of automorphisms. These planes are obtained from the classical flat Minkowski plane by ‘bending’ circles at a distinguished circle.
Finite-time integral sliding mode control for chaotic permanent magnet synchronous motor systems
Authors: Chibani Abdelilah , Daaou Bachir , Gouichiche Abdelmadjid , Safa Ahmed , Messlem Youcef
Published: June 2017

In this paper, an integral finite-time sliding mode control scheme is presented for controlling a chaotic permanent magnet synchronous motor (PMSM). The controller can stabilize the system output tracking error to zero in a finite time. Using Lyapunov’s stability theory, the stability of the proposed scheme is verified. Numerical simulation results are presented to present the effectiveness of the proposed approach.
Research on the influence of driving harmonic on electromagnetic field and temperature field of permanent magnet synchronous motor
Authors: Qiu Hongbo , Yu Wenfei , Li Yonghui , Yang Cunxiang
Published: June 2017

At present, the drivers with different control methods are used in most of permanent magnet synchronous motors (PMSM). A current outputted by a driver contains a large number of harmonics that will cause the PMSM torque ripple, winding heating and rotor temperature rise too large and so on. In this paper, in order to determine the influence of the current harmonics on the motor performance, different harmonic currents were injected into the motor armature. Firstly, in order to study the influence of the current harmonic on the motor magnetic field, a novel decoupling method of the motor magnetic field was proposed. On this basis, the difference of harmonic content in an air gap magnetic field was studied, and the influence of a harmonic current on the air gap flux density was obtained. Secondly, by comparing the fluctuation of the motor torque in the fundamental and different harmonic currents, the influence of harmonic on a motor torque ripple was determined. Then, the influence of different current harmonics on the eddy current loss of the motor was compared and analyzed, and the influence of the drive harmonic on the eddy current loss was obtained. Finally, by using a finite element method (FEM), the motor temperature distribution with different harmonics was obtained.
Impact of inductor current ringing in DCM on output voltage of DC-DC buck power converters
Authors: Walczak Marcin
Published: June 2017

Ringing of an inductor current occurs in a DC-DC BUCK converter working in DCM when current falls to zero. The oscillations are the source of interferences and can have a significant influence on output voltage. This paper discusses the influence of the inductor current ringing on output voltage. It is proved through examples that the oscillations can change actual value of duty a cycle in a way that makes the output voltage difficult to predict.
Improvement of the finite element method equations conditioning for the magnetic field-circuital problems
Authors: Gołębiowski Marek
Published: June 2017

The presented systems with magnetically coupled windings are solved with the finite element method. If the issue of voltage supply is analyzed, a system of linear equations with a partially skew-symmetric sparse matrix is obtained. Iterative methods used to solve a system of equations are particularly effective for symmetric matrices. Resultant equations can be reduced to this symmetrical form by using the method known from the literature [1]. The ratio of the maximum to the minimum eigenvalue of the main matrix of this circuit, which is the condition number, is however very high. This means that the problem is ill-conditioned and leads to a very long iterative solution process. The method presented in the article allows for a direct solution of a system of equations on its part, corresponding to high eigenvalues of the system matrix. The remaining part of the system of equations is solved by iterative methods. This part has much better condition number, and therefore the computational process is fast. The proposed iterative process depends on multiplication of a sparse matrix by vectors. It is not necessary (and possible) to store the entire matrix. This is especially important for larger sizes of a matrix.
The novel control method of switched reluctance generator
Authors: Bogusz Piotr
Published: June 2017

In the paper, a novel control method of a switched reluctance generator was discussed. The presented control method allows a rotor rotating at high speed to enter the continuous-conduction mode which causes an increase of generated output power. A control function of the presented method was given as well as simulation and laboratory tests.
Surface Impedance Boundary Conditions applied to solving nonlinear electrodynamic systems
Authors: Pawłowski Stanisław , Plewako Jolanta
Published: June 2017

The paper presents a method for solving electromagnetic field problems by applying impedance boundary conditions for systems including conducting bodies of nonlinear magnetic properties in an excited harmonic field. Three types of impedance boundary conditions were derived. A procedure for computing surface impedance based on the transfer matrix is proposed. This procedure has been tested by comparing computational results to calculations where time function distortions were considered, and to the experimental data.
Gender Differences and Consumer Behavior of Millennials
Authors: Kraljević Radojka , Filipović Zrinka
Published: June 2017

Millennial generation is considered the largest and best educated and therefore presents challenges to marketers. This paper aims to examine the gender differences in consumer behaviour of students - generation y. The study identifies gender differences in purchase behaviour, loyalty, price sensitivity and shopping habits. The empirical analysis is based on data obtained from a student survey (N=118; M=40, 68%, F=59, 32%). The data were analysed using chi-square test. Our findings suggest that women are more sensitive to price than men. They also belong more to the loyalty programs and use more loyalty awards schemes. Although the millennial generation has the reputation for being digital our study shows that they actually like visiting the stores instead of shopping online although the statistically significant difference is not found.
Managing Macroeconomic Risks by Using Statistical Simulation
Authors: Merkaš Zvonko , Perkov Davor , Miličević Petra
Published: June 2017

The paper analyzes the possibilities of using statistical simulation in the macroeconomic risks measurement. At the level of the whole world, macroeconomic risks are, due to the excessive imbalance, significantly increased. Using analytical statistical methods and Monte Carlo simulation, the authors interpret the collected data sets, compare and analyze them in order to mitigate potential risks. The empirical part of the study is a qualitative case study that uses statistical methods and Monte Carlo simulation for managing macroeconomic risks, which is the central theme of this work. Application of statistical simulation is necessary because the system, for which it is necessary to specify the model, is too complex for an analytical approach. The objective of the paper is to point out the previous need for consideration of significant macroeconomic risks, particularly in terms of the number of the unemployed in the society, the movement of gross domestic product and the country’s credit rating, and the use of data previously processed by statistical methods, through statistical simulation, to analyze the existing model of managing the macroeconomic risks and suggest elements for a management model development that will allow, with the lowest possible probability and consequences, the emergence of the recent macroeconomic risks. The stochastic characteristics of the system, defined by random variables as input values defined by probability distributions, require the performance of a large number of iterations on which to record the output of the model and calculate the mathematical expectations. The paper expounds the basic procedures and techniques of discrete statistical simulation applied to systems that can be characterized by a number of events which represent a set of circumstances that have caused a change in the system’s state and the possibility of its application in the field of assessment of macroeconomic risks. The method has no limitations. It can be used to study very complex systems by using special computer programs. The method uses reasonable estimates for important economic inputs to determine a set of results, not only one outcome at one point in time, yet there is a multiple-possibilities estimation of a certain risk performance, regarding the range of economic variables used in the model. Attempt to influence and influence itself on certain macroeconomic risks, in today’s economy, occupies one of the primary imperatives of the world, therefore, this paper deals with the mutual correlation and application of statistical simulations in macroeconomic risks measurement in order to better prevention and remediation.
Assessment and Comparison of Tourism Vocabulary Skills in ESL Learners
Authors: Pokupec Martina , Njerš Diana , Benić Hilarija Lozančić
Published: June 2017

Teaching and learning English for professional purposes largely involves the acquisition of specialised vocabulary, with teaching methodology focusing on the development of understanding and usage of specific vocabulary items. Within the wide variety of professional purposes the language is acquired for, teaching learners of tourism and hospitality also requires a focus on a range of specific language skills, mostly based on understanding of diverse types of discourse and strong communication skills in varied language situations and contexts. English for professional purposes thus becomes more specific - English for Tourism and Hospitality - signalling a slightly different approach to teaching and learning, i.e. not heavily based on acquiring vocabulary skills, but shifting focus on strong communication skills and enhancement of the four elementary language skills: reading, writing, listening and speaking.

This paper focuses on assessing and comparing receptive and productive vocabulary skills of learners of English as a Second Language (ESL), with a general hypothesis that learners with greater general language competences do not exhibit major problems in inferencing the meaning of specialised urban tourism vocabulary items.

For this purpose, we selected 10 vocabulary items in context sentences and conducted the Vocabulary Knowledge Scale (VKS) test developed by Wesche and Paribakht (1996) with 1styears students of Tourism and Hospitality and students of Business Economics of the Libertas International University. The results obtained by descriptive statistics, Mann-Whitney U test and Spearman’s rank correlation confirm our general hypothesis.
In Tourism Industry We Talk About Sustainable Development, But We Evaluate Profits and Growth
Authors: Sirk Tanja
Published: June 2017

Tourism is one of the biggest economic sectors, it has a significant impact on the environment. At the same time, the long-term development of tourism also greatly depends on the environment it affects. Experts are unanimous that it is necessary for the longterm existence and development of tourism that it becomes sustainable. Nevertheless, in tourism businesses, sustainable development strategies are not sufficiently present and put into practice. The author of the article presents the argument as a possible reason for this: the management of tourism enterprises as well as management of all the companies is focused on doing business successfully; and because the performance of management is assessed in terms of growth and security of its operations, and not in relation to the measures taken in the field of sustainable development, management gives priority to ensuring relatively short-term growth and security of operations.
Challenges and Aspects of Cyber Security of the Republic of Croatia
Authors: Protrka Nikola , Marić Kristijan , Plećaš Mihael
Published: June 2017

The development of the information and communication technology (ICT), regardless of its many advantages, unfortunately has its disadvantage - the abuse of the cyberworld. The global character of cyberspace is specific in terms of national legislation and its view of specificities. Some countries adopted the recommendation of the Convention on Cybercrime of the Council of Europe (Official Gazette NN-MU 9/02, 4/04) and amended their national legislation, whereas others kept implementing their criminal law solutions, which are outdated and cannot reach the level of this type of criminal offences. Consequently, governments are inclined to cooperate and exchange information about this type of crime due to the fact that the criminal offender may be anywhere, and the offence itself can take place at a great distance from the offender. In September 2015, the government of the Republic of Croatia adopted the National Cyber Security Strategy and the Action Plan for the Implementation of the National Cyber Security Strategy, the first allencompassing strategy of the Republic of Croatia on cyber security. The paper also focuses on the role of the Police College in the Action Plan for the Implementation of the National Cyber Security Strategy.
Thermodynamic study of phase equilibrium of superionic alloys of Ag3SBr1−xClx system in the concentration range 0.0–0.4 and temperature range 370–395 K
Authors: Moroz M.V. , Prokhorenko M.V. , Prokhorenko S.V. , Reshetnyak O.V.
Published: June 2017

Thermodynamic assessment of the phase stability of the solid solutions of superionic alloys of the Ag3SBr1−xClx (I) system in the concentration range 0 ≤ x ≤ 0.4 and temperature range 370-395 K was performed. Partial functions of silver in the alloys of solid solution were used as the thermodynamic parameters. The values of partial thermodynamic functions were obtained with the use of the electromotive force method. Potential-forming processes were performed in electrochemical cells. Linear dependence of the electromotive force of cells on temperature was used to calculate the partial thermodynamic functions of silver in the alloys. The serpentine-like shape of the thermodynamic functions in the concentration range 0-4 is an evidence of the metastable state of solid solution. The equilibrium phase state of the alloys is predicted to feature the formation of the intermediate phase Ag3SBr0.76Cl0.24, and the solubility gap of the solid solution ranges of Ag3SBr0.76Cl0.24 and Ag3SBr.
Thermodynamic analysis of a new dual evaporator CO2 transcritical refrigeration cycle
Authors: Abdellaoui Ezzaalouni Yathreb , Kairouani Lakdar Kairouani
Published: June 2017

In this work, a new dual-evaporator CO2transcritical refrigeration cycle with two ejectors is proposed. In this new system, we proposed to recover the lost energy of condensation coming off the gas cooler and operate the refrigeration cycle ejector free and enhance the system performance and obtain dual-temperature refrigeration simultaneously. The effects of some key parameters on the thermodynamic performance of the modified cycle are theoretically investigated based on energetic and exergetic analysis. The simulation results for the modified cycle indicate more effective system performance improvement than the single ejector in the CO2vapor compression cycle using ejector as an expander ranging up to 46%. The exergetic analysis for this system is made. The performance characteristics of the proposed cycle show its promise in dual-evaporator refrigeration system.
Determination of dryout localization using a five-equation model of annular flow for boiling in minichannels
Authors: Wajs Jan , Mikielewicz Dariusz
Published: June 2017

Detailed studies have suggested that the critical heat flux in the form of dryout in minichannels occurs when the combined effects of entrainment, deposition, and evaporation of the film make the film flow rate go gradually and smoothly to zero. Most approaches so far used the mass balance equation for the liquid film with appropriate formulations for the rate of deposition and entrainment respectively. It must be acknowledged that any discrepancy in determination of deposition and entrainment rates, together with cross-correlations between them, leads to the loss of accuracy of model predictions. Conservation equations relating the primary parameters are established for the liquid film and vapor core. The model consists of three mass balance equations, for liquid in the film as well as two-phase core and the gas phase itself. These equations are supplemented by the corresponding momentum equations for liquid in the film and the two-phase core. Applicability of the model has been tested on some experimental data.
Pollutant bioaccumulation in anchovy (Engraulis encrasicolus) tissue, fish species of commercial interest at the Romanian Black Sea coast
Authors: Galaţchi Mădălina , Oros Andra , Coatu Valentina , Costache Mioara , Coprean Dragomir , Galaţchi Liviu-Daniel
Published: June 2017

The pollution of the marine ecosystem is a world-wide problem. Heavy metals and organochlorine compounds are among the most harmful elemental pollutants and are of particular concern because of their toxicity to humans. Anchovy (Engraulis encrasicolus, Linnaeus 1758), small pelagic fish with a key ecological role in the marine food web, is an important link connecting the lower and upper trophic levels, being also a valuable species for human consumption. Thus, anchovy samples were collected from different stations along the Romanian Black Sea coast and the analyzed contaminants were organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs) and heavy metals (Cd, Pb, Ni, Cu and Cr) in muscle tissue. Cd and Pb are the heavy metals that exceeded the allowed levels under the EU legislation (0.3 μg/g), Cd recorded values within the range 0.29-0.51 μg/g (average 0.36 ± 0.09 μg/g) and Pb recorded values within the interval 0.29-1.62 μg/g (average 0.75 ± 0.57 μg/g). Regarding organochlorine pesticides, the highest level was recorded by p,p′-DDE (6.76±1.21 ng/g/dry weight), followed by p,p′-DDD (3.88±0.97 ng/g/dry weight). Among PCB’s, the highest level was recorded by PCB 28 (5.19±1.29 ng/g/dry weight). The results of this study revealed that heavy metals, pesticides and polychlorinated biphenyls values identified in anchovy tissue, species of commercial interest from the Black Sea, are not threatening to human consumers.
High Borate Networks as a Platform to Modulate Temporal Release of Therapeutic Metal Ions Gallium and Strontium
Authors: O’Connell Kathleen , Werner-Zwanziger Ulrike , O’Shea Helen , Boyd Daniel
Published: June 2017

The effect of increasing substitutions of Ga
Evaluation of anticancer properties of a new α-methylene-δ-lactone DL-249 on two cancer cell lines
Authors: Pomorska Dorota K. , Gach-Janczak Katarzyna , Jakubowski Rafał , Janecki Tomasz , Szymański Jacek , Janecka Anna
Published: June 2017

Background

The anticancer activity of a new synthetic α-methylene-δ-lactone DL-249 was reported in leukemia HL-60 and breast cancer MCF-7 cells and compared with the activity of a natural α-methylene-γ-lactone from Tanacetum parthenium, parthenolide.

Methodology

The chemical synthesis of DL-249 was performed using Horner-Wadsworth-Emmons methodology. The cytotoxic activity of the tested compounds was assessed by an MTT test. The ability to induce apoptosis was studied by flow cytometry. The expression levels of genes were determined by quantitative real-time PCR.

Principal Findings/Results

DL-249 and parthenolide inhibited the growth of HL-60 and MCF-7 cells with IC50 values below 10 μM. DL-249 was a stronger apoptosis inducer than parthenolide in both cell lines and both compounds produced a more pronounced effect on HL-60 than on MCF-7 cells. DL-249 and PTL significantly up-regulated expression of Bax, caspase-9, caspase-3 and p53 genes and decreased the level of Bcl-2 and Bcl-xl genes in both cancer cell lines. Additionally DL-249 caused cell cycle arrest in the subG0/G1phase.

Conclusion/Significance

A new synthetic α-methylene-δ-lactone, DL-249 showed the anticancer activity on two cancer cell lines and seemed to be a better apoptosis inducer than parthenolide which makes this compound an attractive lead for further studies.
On Some Mechanical Properties and Wear Behavior of Sintered Bronze Based Composites Reinforced with Some Aluminides Microadditives
Authors: Feldshtein E. , Kiełek P. , Kiełek T. , Dyachkova L. , Letsko A.
Published: June 2017

In the paper, the changes in some mechanical properties and wear behavior of CuSn10 sintered bronze and MMCs based on this bronze reinforced with composite ultrafine aluminide powders FeAl/15 % Al2O3, NiAl/15 % Al2O3 and Ti-46Al-8Cr are described. It was observed that the presence of aluminides in the MMCs leads to an increase in the hardness, but the flexural strength may increase or decrease depending on the type of aluminide. The presence of aluminides in the MMC reduces the wear rate considerably. It is decreased in the direction of FeAl/15 % Al2O3 → NiAl/15 % Al2O3 → Ti-46Al-8Cr aluminides and for the best MMC composition the advantage is about 20 times. In the MMCs wear process, micro-craters are formed on the contact surface and it is the principal reason of a decrease in the wear rate.
Effect of Relative Velocity Between Rough Surfaces: Hydrodynamic Lubrication of Rotary Lip Seal
Authors: Lahjouji I. , Gadari M. El , Fahime B. El , Radouani M.
Published: June 2017

Since the sixties, most of numerical studies that model the rotary lip seal lubrication have been restricted by assuming that one of the two opposing surfaces is smooth: either the lip or the shaft. This hypothesis, although it is verified only for a shaft roughness ten times smaller than that of the seal, is the best solution to avoid the transient term “∂h/∂t” in the deterministic approach. Thus, the subject of the present study is twofold. The first part validates the current hydrodynamic model with the international literature by assuming the asperities on the lip and shaft as a two-dimensional cosine function. In the second part the Reynolds equation for rough surfaces with relative motion is solved. The numerical results show that the relative motion between rough surfaces impacts significantly the load support and the leakage rate, but affects slightly the friction torque.
Unsteady MHD Mixed Convection Flow of a Micropolar Fluid Over a Vertical Wedge
Authors: Roy N.C. , Gorla R.S.R.
Published: June 2017

An analysis is presented to investigate the unsteady magnetohydrodynamic (MHD) mixed convection boundary-layer flow of a micropolar fluid over a vertical wedge in the presence of thermal radiation and heat generation or absorption. The free-stream velocity and surface temperature are assumed to be oscillating in magnitude but not in the direction of the oncoming flow velocity. The governing equations have been solved by two distinct methods, namely, the finite difference method for the entire frequency range, and the series solution for low frequency range and the asymptotic series expansion method for the high frequency range. Numerical solutions provide a good agreement with the series solutions. The amplitudes of skin friction and couple stress coefficients are found to be strongly dependent on the Richardson number and the vortex viscosity parameter. The Prandtl number, the conduction-radiation parameter, the surface temperature parameter and the pressure gradient parameter significantly affect the amplitudes of skin friction, couple stress and surface heat transfer rates. However, the amplitudes of skin friction coefficient are considerably affected by the magnetic field parameter, whereas the amplitudes of heat transfer rate are appreciably changed with the heat generation or absorption parameter. In addition, results are presented for the transient skin friction, couple stress and heat transfer rate with the variations of the Richardson number, the vortex viscosity parameter, the pressure gradient parameter and the magnetic field parameter.
Fem and Experimental Analysis of Thin-Walled Composite Elements Under Compression
Authors: Różyło P. , Wysmulski P. , Falkowicz K.
Published: June 2017

Thin-walled steel elements in the form of openwork columns with variable geometrical parameters of holes were studied. The samples of thin-walled composite columns were modelled numerically. They were subjected to axial compression to examine their behavior in the critical and post-critical state. The numerical models were articulately supported on the upper and lower edges of the cross-section of the profiles. The numerical analysis was conducted only with respect to the non-linear stability of the structure. The FEM analysis was performed until the material achieved its yield stress. This was done to force the loss of stability by the structures. The numerical analysis was performed using the ABAQUS® software. The numerical analysis was performed only for the elastic range to ensure the operating stability of the tested thin-walled structures.
Transport of MHD Couple Stress Fluid Through Peristalsis in a Porous Medium Under the Influence of Heat Transfer and Slip Effects
Authors: Sankad G.C. , Nagathan P.S.
Published: June 2017

An attempt has been made to examine the effects of magnetohydrodynamic couple stress fluid in peristaltic flow with porous medium under the impact of slip, heat transfer and wall properties. The expressions are obtained for temperature, coefficient of heat transfer and velocity. Influences of different parameters, the Hartmann number, Brinkman number and adaptability parameters on the temperature and warmth trade coefficient are discussed through outlines.
Essential Factors For The Changes In Concrete During Electrochemical Extraction
Authors: Alsabry A.
Published: June 2017

The objective of the article is to present one of the most significant factors affecting electrochemical removal of chloride ions from concrete. Based on the literature findings, tests were carried out on specimens containing chloride admixtures introduced to the cement grout, on elements subjected to chloride penetration from the solution in laboratory conditions and on fragments of constructions penetrated by chlorides as a result of a long-term exposure to seawater.
Identification Damage Model for Thermomechanical Degradation of Ductile Heterogeneous Materials
Authors: Amri A. El , Yakhloufi M.H. El , Khamlichi A.
Published: June 2017

The failure of ductile materials subject to high thermal and mechanical loading rates is notably affected by material inertia. The mechanisms of fatigue-crack propagation are examined with particular emphasis on the similarities and differences between cyclic crack growth in ductile materials, such as metals, and corresponding behavior in brittle materials, such as intermetallic and ceramics. Numerical simulations of crack propagation in a cylindrical specimen demonstrate that the proposed method provides an effective means to simulate ductile fracture in large scale cylindrical structures with engineering accuracy. The influence of damage on the intensity of the destruction of materials is studied as well.
Evaluation of Vitamin D, Vitamin D Binding Protein Gene Polymorphism with Oxidant – Antioxidant Profiles in Chronic Obstructive Pulmonary Disease
Authors: Al-Azzawi Mahmood A. , Ghoneim Adel H. , Elmadbouh Ibrahim
Published: June 2017

Background: The aim was to evaluate the association of plasma 25-hydroxyvitamin D (25-OHD) and vitamin D binding protein (VDBP or Gc-globin) gene polymorphism with oxidant-antioxidant profiles in patients with chronic obstructive pulmonary disease (COPD), and their role as biomarker risk factors in susceptibility and severity of COPD. Methods: Eighty patients diagnosed with COPD (mild, moderate and severe according to lung function tests; FEV 1%) and 80 healthy controls were included in the study. Serum nitric oxide (NO) and lipid peroxide (LP), plasma reduced glutathione (RGSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activity, 25-OHD and VDBP polymorphism were analyzed in all subjects. Results: COPD patients had significantly decreased serum NO, plasma SOD, RGSH, GSH-Px, CAT and 25-OHD versus controls, but had significantly increased serum LP. In COPD patients, 25-OHD levels were significantly lower (41.49± 13.65 ng/mL) versus controls, but more lower in severe COPD patients (30.54±9.09 ng/mL; sensitivity 79.2%; spe - cificity 73.2%, p<0.001) versus mild and moderate COPD. VDBP genotypes frequencies were Gc1S-1S=23.8%, Gc1F-1S=28.8%, Gc1F-1F=15%, Gc1S-2=20%, Gc1F-2=11.3% and Gc2-2=1.3%. Also, VDBP variants frequencies were Gc1S=48.1%, Gc1F=35% and Gc2=16.6%. How ever, Gc1F-1S genotypes and Gc1F variants were significantly higher than in controls (10%, 12.5%; p=0.009, p=0.001, respectively). Moreover, in severe COPD patients, Gc1F-1S genotype was significantly higher than in mild COPD (41.7% vs 31.3%, p=0.04). Conclusion: COPD patients had significantly lower plasma 25-OHD and were associated with significantly higher VDBP Gc1F-1S genotypes and Gc1F variants frequencies than controls. Low vitamin D levels and VDBP polymorphism may be important as diagnostic risk factors in the susceptibility to and severity of COPD.
Laboratory Medicine Management: Leadership Skills for Effective Laboratory
Authors: Majkić-Singh Nada
Published: June 2017

Forum of the European Societies of Clinical Chemistry (FESCC) decided that the FESCC Symposium for Balkan Region would be held each year in Belgrade and organized by the Society of Medical Biochemists of Serbia and Montenegro (SMBSM). Professor Victor Blaton, at the time President of the FESCC, supported the organization of the Symposium. Purpose of these Symposia has been to educate clinical biochemists from Balkan region to improve management, leadership skills for effective laboratories. As a result of these decision twelve symposia have been organized thus far very successfully. Here the most important Symposium topics will be reviewed. Also, the 13thEFLM Symposium for Balkan Region under the title »Laboratory Medicine Management: Leadership Skills for Effective Laboratory«(Belgrade, September 2017) is organized by EFLM and SMBS under the Auspices of the International Federation of Clinical Chemistry (IFCC), Ministry of Education, Science and Technological Development of Serbia and Ministry of Health of Serbia with participation of the European and domestic specialists in field of Laboratory Medicine.
The temporalized Massey’s method
Authors: Franceschet Massimo , Bozzo Enrico , Vidoni Paolo
Published: June 2017

We propose and throughly investigate a temporalized version of the popular Massey’s technique for rating actors in sport competitions. The method can be described as a dynamic temporal process in which team ratings are updated at every match according to their performance during the match and the strength of the opponent team. Using the Italian soccer dataset, we empirically show that the method has a good foresight prediction accuracy.
Dynamic capabilities in strategic choice processes within organisations
Authors: Krzakiewicz Kazimierz , Cyfert Szymon
Published: June 2017

Dynamic capabilities are an essential theoretical construct that is useful for understanding the phenomenon of competition. Still, in spite of the apparent popularity of this subject, the existing management literature could do with more studies into processes that shape dynamic capabilities.

The purpose of this article is to systematise different approaches to the dynamic capabilities concept as they are found in the existing literature, with a particular focus on its relevance to modern-day organisations as a tool to increase their competitiveness. The other goal is to discuss two issues that are critical to the dynamic capabilities concept. Firstly, what are the conditions for the predominant role of dynamic capabilities in the area of strategic management? Secondly, can the dynamic capabilities concept be treated as an underlying theoretical and methodological framework for strategic choices in modern-day organisations?
In search for effective methods of routine formation
Authors: Kandora Marcin
Published: June 2017

Organizational routines are a frequently researched phenomenon in contemporary management science. Although the available theoretical foundations of Routine Theory seem to have reached a significant degree of maturity over the last thirty years, the same could not be said about the availability of material advice for the management practice. This paper addresses this gap and proposes a framework for an effective routine shaping process. It builds on a brief analysis of available literature on routine formation, supported by case study findings. The approach proposed stresses the importance of the controlled learning process and underlines the importance of deliberate implementation, in contrast to the evolutionary and engineering views on routine emergence.
Features of the international manager-leader of the near future - findings of the research
Authors: Glinkowska Beata
Published: June 2017

The paper covers characteristics of the conducted research, including definitional approach to the essence of the terms: manager and leader. Particular attention was paid to the qualities of modern manager-leader and the qualities of manager-leader of the future, including globalization and internationalisation. The research part contains findings of the author’s own research which were confronted with the results of studies existing in this area in the subject literature.
Assumptions to the model of managing knowledge workers in modern organizations
Authors: Igielski Michał
Published: June 2017

Changes in the twenty-first century are faster, suddenly appear, not always desirable for the smooth functioning of the company. This is the domain of globalization, in which new events - opportunities or threats, forcing the company all the time to act. More and more things depend on the intangible assets of the undertaking, its strategic potential. Certain types of work require more knowledge, experience and independent thinking, and custom than others. Therefore in this article the author has taken up the subject of knowledge workers in contemporary organizations. The aim of the study is to attempt to create assumptions about the knowledge management model in these organizations, based on literature analysis and empirical research. In this regard, the author describes the contemporary conditions of employee management and the skills and competences of knowledge workers. In addition, he conducted research (2016) in 100 medium enterprises in the province of Pomerania, using a tool in the form of a questionnaire and an interview. Already at the beginning of the analysis of the data collected, it turned out that for all employers it should be important to discern differences in the creation of a new category of managers who have knowledge useful for the functioning of the company. Moreover, with the experience gained in a similar research process previously carried out in companies from the Baltic Sea Region, the author knew about the positive influence of these people on creating new solutions or improving the quality of already existing products or services.
The decision-making process in public healthcare entities – identification of the decision-making process type
Authors: Szymaniec-Mlicka Karolina
Published: June 2017

The decisions made in the organization determine its success, therefore, conducting studies in the scope of decision-making seems important both for theory and practice. The aim of the studies was to identify the type of decision-making process in public medical entities with the use of typology developed by P. Nutt. For this purpose we used qualitative methods. Interviews with 8 directors of hospitals were conducted and the reconstruction was made on the basis of the decision-making process, which enabled the assignment of the model of decision-making process to the organization. The research indicated that four organizations use the historical decision-making model, three organizations represent the model of generating solutions, and one organization uses the model of available solutions.
Craft villages and tourism development, a case study in Phu Quoc island of Vietnam
Authors: Hieu Vu , Rasovska Ida
Published: June 2017

Craft tourism is attracting many domestic and foreign tourists. In recent years in Vietnam, craft villages have exploited their potentials in tourism industry. For many different causes, tourism activities have yet reached expectations and their potentials for tourism development. This paper is to review their currents, tourism potentials and limitations and then formulate recommendations to the tourism development in Phu Quoc island. The data for this paper are from two sources. Secondary data were collected from the vast literature and journals. Primary data were from interviews with village owners, related authorities, tourists, tourism corporate, etc. and results serve as guidelines to develop the tourism industry and management.