bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Cherry Laurel Cultivar: 'Odü'
Authors: İslam Ali
Published: December 2024

Objective: 'Odü' is a new cultivar of cherry laurel developed for table consumption. The aim of this study is to describe the new cherry laurel variety and to reveal fruit characteristics.
Materials and Methods: Before the study, 32 promising types were determined by the selection study carried out in the Black Sea region between 2007-2010. One of these genotypes was encoded with A19. The type was propagated by cuttings in 2010-2011 and, planted in a trial plot with 6 plants in 2012. Fruit bearing started in 2015 and the results of the research covered the years 2017-2019. Fruit, cluster, seed and leaf characteristics of the 'Odü' cherry laurel variety were observed and examined.
Results: The fruit characteristics of the ‘Odü’ variety, including size, weight, and color, were carefully observed and categorized. The fruit weight was 2.68 g, the fruit size was 15.96 mm, the fruit stem length was 5.54 mm, the seed weight was 0.39 g, the cluster length was 12.17 cm, the cluster weight was 39.54 g, and the number of fruits in the cluster was 16.67. Leaf width and length were determined as 4.51 cm and 15.06 cm, and annual shoot length was 59.85 cm. Cluster length was "medium", number of flowers in clusters was “intensive”. Fruit size was classified as "middle", leaf shape was classified as "narrow elliptical".
Conclusion: Cherry laurel is used as a fruit and ornamental plant. As a fruit, the 'Odü' cultivar is the first registered fruit variety in Türkiye and in the world. As an evaluation, the 'Odü' cultivar produces medium-sized fruits, with a dense cluster structure and light fruit color, characteristic of small to medium-sized trees. The following points can be suggested. The cherry laurel is a promising fruit species for our country as product diversity and alternative taste characteristics. Cultivar registration is commercially the first step for establishing an orchard and paving the way for production. This study and registration is important as fruit diversity in the Blacksea region.
Unfired Bricks Green Material with Microorganism Biocementation
Authors: Indriani Andi Marini , Utomo Gunaedy , Maslina  , Az’Zahrah Yuninda , Ochtharima Zaerima Zahira
Published: December 2024

The disposal of industrial sludge from Water Treatment Plants (WTP) poses environmental risks, particularly groundwater pollution. One solution is reusing this sludge in brick production, as clay use is unsustainable and may lead to shortages. This research investigates innovations in brick making, specifically using WTP sludge and the Microbially Induced Calcite Precipitation (MICP) technique with Bacillus huizhouensis to enhance brick strength. The MICP method produces calcium carbonate (CaCO₃) naturally, reinforcing bricks without harmful burning. After 50 days, compressive tests showed that bio-bricks with 15% WTP sludge and 25% bacteria achieved the highest strength of 3.79 MPa, compared to 1.49 MPa for mud bricks with only sludge. However, bio-bricks with 6% bacteria and 15% sludge reached only 1.74 MPa, with all values below the SNI 15-2094-2000 standard of 5 MPa.
Business Analysis of Lift Net Operation in Bone Bay, Bone Regency, South Sulawesi
Authors: Harahap Kurnia Sada , Maskur Muhammad , Sogirun Muhammad , Najih Mohammad Roin , Kusmedy Bombongan
Published: December 2024

The bagan boat is a type of fishing gear that utilizes light to attract schools of fish, either through positive phototaxis or by luring fish searching for food around the light. This method is particularly effective for catching pelagic species such as anchovies, tuna, and squid. This study evaluates the financial feasibility of operating bagan boat fishing gear in Bone Bay, South Sulawesi, through several key financial indicators, including Profit/Loss Analysis, Payback Period (PP), Net Present Value (NPV), and Revenue Cost Ratio (R/C Ratio). The analysis of the operational costs revealed total costs amounting to Rp 487,826,666, which include depreciation, maintenance, and operational expenses. The total revenue generated from the operation was Rp 951,243,999, resulting in a Revenue Cost Ratio (R/C ratio) of 1.95, indicating profitability. The Payback Period (PP) was calculated at 1.56 years, demonstrating a relatively quick return on investment. Additionally, the Net Present Value (NPV) was found to be Rp 1,078,386,238, confirming that the investment generates positive returns. Based on these findings, the operation of bagan boat fishing gear is deemed financially viable, profitable, and sustainable, with strong potential for future growth and development.
Characterization of TPO Enzyme and its Immunogenecity in New Zealand White Rabbits (Oryctolagus cuniculus)
Authors: Ramadani Devi , Wijaya Andreas Budi , Srihardyastutie Arie , Wuragil Dyah Kinasih , Rosandi Rulli , Rudijanto Achmad , Aulanni'am Aulanni'am
Published: December 2024

Hypothyroidism is characterized by inadequate production of thyroid hormones, chiefly thyroxine (T4) and triiodothyronine (T3). Thyroid peroxidase (TPO), is an enzyme and crucial for producing thyroid hormones, and also serves as a primary autoantigen in autoimmune thyroid conditions, such as Hashimoto's thyroiditis and Graves' disease. The existence of anti-thyroid peroxidase antibodies (anti-TPO) indicates an autoimmune response in which the immune system TPO which is normally recognized as part of the body (self), begins to be identified by the immune system as a something foreign (non-self). This study aimed to characterize, measure TPO activity, and evaluate the immunogenicity of TPO protein derived from patient serum and its ability to induce TPO antibody production in New Zealand White Rabbits. TPO protein isolation was achieved through SDS-PAGE and confirmed by western blot technique have molecular weight of 52 kDa. In samples from normal patients, the average TPO enzyme activity was 31.34 U/mL, while in hypothyroid patients, the average activity increased to 49.46 U/mL. TPO polyclonal antibody production in rabbits indicated its immunogenicity, peaking in week eight post-immunization, with an ELISA absorbance of 0.555. Dot blot analysis further confirmed anti-TPO sensitivity at various dilutions, anti-TPO has a high sensitivity at 1:80 dilution still detects TPO in sera patient.
DETERMINANTS OF AUDITOR’S ABILITY TO DETECT FRAUD
Authors: Deliana Deliana , Purba Sadaukur Aeroki , Rahman Abdul , Syahputra Rizki , Sari Eka Nurmala , Jamaludin Mohd Faizal Bin
Published: December 2024

The study aims to provide empirical evidence on the effect of work experience, professional scepticism and time pressure on the ability of auditors to detect fraud. This research uses quantitative research methods that use statistical analysis tools, namely using Smart PLS (Partial Least Square) software. The data used is primary and comes directly from those surveyed, using a questionnaire designed to collect it. The questionnaires were distributed through the provision of paper questionnaires and through Google forms that were sent directly to the respondents. Sample in this study were 33 auditors in Medan City. The results of this study indicate that work experience positively affects the auditor's ability to detect fraud, while professional scepticism and time pressure do not affect the auditor's ability to detect fraud.
 
 
 
 
 
 
Keywords     : Ability to Detect Fraud, Professional Skepticism, Time Pressure, Work Experience.
THE EFFECT OF TAX AVOIDANCE, ESG, AND POLITICAL CONNECTION ON FIRM VALUE 2021-2023
Authors: Sadjiarto Arja , Karistianto Kalef , Tjandra Putri Meydelin
Published: December 2024

This study aims to investigate whether tax avoidance, ESG, and political connections affect firm value under current conditions. The purpose of this research is to examine the effects of tax avoidance, ESG, and political connections on firm value. Data analysis was conducted using Gretl. The sample consists of publicly traded non-financial companies from 2021 to 2023. The study uses a purposive sampling technique, resulting in 159 observations. This quantitative research utilizes multiple linear regression. Data was obtained from the Refinitiv Database and Annual Reports. The results show that ESG and tax avoidance significantly affect firm value, whereas political connections do not have an impact on firm value. The expected contribution of this research is to enhance transparency among all stakeholders, demonstrating the company’s commitment to tax compliance, ESG, implementation, and corporate governance, thereby increasing firm value.
 
Keywords     : ESG, Firm Value, Political Connection, and Tax Avoidance
Participatory Communication in Children’s Communities for Preventing Child Marriage after the COVID-19 Pandemic in Sukabumi
Authors: Sri Utami Yessi
Published: December 2024

The high rate of child marriage cases in Sukabumi Regency following the COVID-19 pandemic has encouraged the children’s community in Sukabumi to form unique cooperation with the government. This research aims to analyze the participatory communication between the child community and the government in preventing child marriage and achieving Sustainable Development Goals (SDGs) after the COVID-19 pandemic in Sukabumi, West Java. The research employs a qualitative method with a case study approach, analyzing several children’s communities. Data collection was conducted using multiple sources, including observation, interviews, and documentation studies. This research shows that participatory communication within the children’s community enhances adolescent agency communally through dialogue, heteroglossia, polyphony, and carnival. Dialogue was found to be the dominant form and plays a major role in realizing effective communication. Children’s communities used both digital and face-to-face media to achieve resilience and build participation during the COVID-19 pandemic, with face-to-face media being more dominant in interactions with the government. This study found that participatory communication increases collaboration between the children’s community and the government, contributing to the reduction of child marriage in Sukabumi.
Ideal Beauty Representation: Multimodality Analysis of Scarlett Whitening’s Content with Song Joong-Ki
Authors: Silvia Atika , Syawal Marsaa Salsabila , Pinem Meyka Septira Utami , Hanum Ratu Suud
Published: December 2024

Advertising as a form of communication is considered an effective tool to promote sales. According to the stereotype in the public, beauty brands usually are represented by women. For Scarlett Whitening's advertisement, Song Joong-Ki is chosen as their ambassador even though there is still a stereotype of men’s role, especially in advertisements. This research aims to describe modality and analyze ideational, interpersonal, and compositional meta-functions in collaboration content between Scarlett Whitening and Song Joong-Ki. This research was conducted with a qualitative approach and using multimodality methods by Kress & Van Leeuwen (2006) with the type of social semiotics research. The results show that Song Joong-Ki invites the audience to focus on the product, shows a close relationship with the audience, and shows his love for the product and the audience. Scarlett Whitening emphasizes the representation of beauty standards, the Pan-Asian Look, which is identical to clean white skin, marketed and represented visually with Song Joong-Ki as the primary focus. Results also demonstrated Song Joong-Ki's usage of beauty products as a male in the campaign and that the marketer may use his status as a Korean actor to employ Parasocial contact with his fans as market targets.
Emerging the Submerged Realities of Mass Rape in the News of May 1998 Riot
Authors: Kezia Sola Gratia
Published: December 2024

This study employs agenda-setting and media fragmenting theory alongside critical analysis of discourse studies (CADS) to scrutinize media dynamics during the May 1998 Riots in Indonesia. Agenda-setting and Media Framing theories analyze how the media prioritizes and frames specific issues. At the same time, CADS provides a method to present a detailed examination of language and representation in media texts. By analyzing 296 and 261 news articles from two of the most prominent Indonesian online newspaper platforms, the study investigates the submersion of discourses on gender and ethnic violence. Utilizing CADS, the research conducts frequency, collocation, concordance, cluster, and keyword analyses to uncover hidden narratives of gender and ethnic violence within the riot coverage. The analysis reveals significant gaps in discourse on racial and gender-based violence, highlighting the importance of identifying underlying narratives in news coverage. Additionally, the study underscores a void in the coverage of gender and ethnic violence discourses related to the May 1998 Riots, suggesting potential oversight or suppression of crucial aspects. This highlights the media's dual role as a reflector of events and an active influencer of public narratives.
Incumprimento Terapêutico: O Grande Fator de Risco
Authors: Isabel Campos Dina
Published: December 2024

O incumprimento terapêutico é deveras comum e subestimado numa população cada vez mais envelhecida e de mãos dadas com a multimorbilidade, comprometendo resultados e aumentando custos em saúde. A adesão é um processo dinâmico influenciado simultaneamente por múltiplos fatores, relacionados ou não com o doente, que devem ser considerados antes e após a prescrição e sujeitos a um acompanhamento contínuo no tempo. O adereçamento destes fatores e sua adequação individualizada, com reforço da motivação intrínseca e envolvimento do doente na estratégia terapêutica pode ser uma das medidas mais eficazes no combate das doenças crónicas e, consequentemente, na melhoria dos resultados em saúde.
Fibromyalgia and Somatic Symptom Disorder: Two Sides of the Same Coin?
Authors: Alves Tânia , Santos Mónica , Branco Margarida , Moreira Sara
Published: December 2024

Fibromyalgia affects about 1.78% of the population worldwide and has been recognized and studied since the 16th century. Despite that, the etiopathogenesis of fibromyalgia is still unknown. Consequently, there is still an ongoing debate whether fibromyalgia should be considered within the category of somatization disorders, or as a central pain sensitization syndrome, or even as a peripheral nerve disease. We consider that this is a relevant issue, since it impacts the referral of these patients to the different healthcare professionals, the type of assessment that is provided and the therapeutic approaches that are proposed to them.Several aspects point to similarities between fibromyalgia and somatic symptom disorder: both diagnoses share high comorbidity with several psychiatric disorders, a history of childhood trauma, the presence of alexithymia and other personality traits, insecure attachment styles and comorbidity with the so-called chronic overlapping pain conditions. Therefore, we hypothesize that fibromyalgia can be conceptualized as a somatic symptom disorder. However, the debate continues, since there is still a lack of scientific evidence supporting either in favor or against this perspective. More studies are needed to unveil the etiopathogenesis behind these two diagnoses.
Iuris Scientia Volume II
Authors: Santos Ana Rafaela Medeiros , Câmara Anne Cristine Trindade de Araújo , Figueirêdo Claudianor Almeida de , Figueirêdo Cleison Iohansson Silva , Barboza Filho Francisco de Assis , Cunha Francisco Fernandes da , Vieira Isadora Costa , Costa José Carlos da , Pereira Laura Maria , Silva Lucineide de Araújo , Silva Marcos Mendonça da , Félix Pedro Sérgio Pereira , Elias Raimundo Francisco de , Medeiros Roberth Batista de , Santos Silva Mara dos
Published: December 2024

Iuris Scientia Volume II
IMPACTO DA TOXOPLASMOSE NA SAÚDE MATERNO-INFANTIL: DIAGNÓSTICO E PREVENÇÃO
Authors: OLIVEIRA MARIA EMÍLIA DANTAS , SANTOS LETÍCIA VITÓRIA DA SILVA , CONCEIÇÃO KASSYANI MÊNEDY FARIA DA , SANTOS THALITA VICTÓRIA MARQUES , SANTANA THAIONARA SANTOS , ALBUQUERQUE JULIANA CRISTINA DE SOUZA , MAGALHÃES CLAUDIA CHRISTINA RIBEIRO GUIMARÃES NERI DE , ALFAIA ARIANA DANTAS , BORGES VITÓRIA CAMILLY ROCHA , LIMA ELAYNNE JEYSSA ALVES
Published: December 2024

Introdução: Durante a gestação, a infecção por Toxoplasma gondii pode resultar em sérias complicações, incluindo
aborto espontâneo, morte fetal e uma série de malformações. Portanto, o diagnóstico precoce e preciso da toxoplasmose
em gestantes é crucial para a implementação de estratégias de prevenção e intervenção que possam minimizar os riscos
associados à infecção. Objetivo: Analisar as estratégias de prevenção e os impactos específicos da toxoplasmose na saúde
materno-infantil. Metodologia: Trata-se de uma ampla revisão integrativa da literatura. A coleta de dados foi realizada
através de uma busca avançada nos bancos de dados da MEDLINE e SciELO. Resultados e Discussão: As formas de
diagnóstico da toxoplasmose incluem testes sorológicos para detectar anticorpos, PCR para detectar DNA do Toxoplasma
gondii, e ultrassonografia para sinais de infecção fetal. A prevenção envolve educação das gestantes sobre riscos e higiene,
triagem pré-natal e tratamento adequado das gestantes infectadas. Consequências para a saúde materno-infantil incluem
sequelas neurológicas e visuais, perda auditiva e complicações graves no recém-nascido se a infecção não for tratada
precocemente. Considerações Finais: Conclui-se que a prevenção eficaz e o diagnóstico precoce são fundamentais para
mitigar os impactos adversos da toxoplasmose na saúde materno-infantil, enfatizando a importância contínua de
estratégias educativas e de saúde pública.
BARREIRAS AO ACESSO À SAÚDE EM POPULAÇÕES VULNERÁVEIS
Authors: MELLO PRISCILA GOMES DE , BORGES VITÓRIA CAMILLY ROCHA , SANTOS MARIA TEREZA CAETANO DOS , ALENCAR HUGO BARBOSA , FALCÃO SARA MARIA COSTA , COSTA THAYANNE THYSSYANNE DE SOUZA SOARES , OLIVEIRA EDUARDA GABRIELLY KRYNSKI DE , SILVA MARIA JOSÉ DA , ASSUNÇÃO ÉLIDA LÚCIA FERREIRA , LIMA ELAYNNE JEYSSA ALVES
Published: December 2024

Introdução: Acesso equitativo aos serviços de saúde é um desafio persistente, especialmente para populações
vulneráveis, que enfrentam uma variedade de barreiras que comprometem sua saúde e bem-estar. Identificar e
compreender essas dificuldades é crucial, pois elas podem agravar desigualdades existentes e resultar em piores desfechos
de saúde. Objetivo: Investigar as dificuldades de acesso à saúde que são enfrentadas por diferentes populações
vulneráveis Metodologia: Trata-se de uma abrangente revisão integrativa da literatura, conduzida em 2024 mediante
consulta às respectivas bases de dados PubMed, Embase e Scopus. Resultados e Discussão: As barreiras de acesso à
saúde para populações vulneráveis incluem fatores econômicos, como pobreza e baixo status socioeconômico, que
aumentam os riscos de saúde. Há também obstáculos físicos e atitudinais nos serviços de saúde, como a falta de
empoderamento, interrupção de tratamentos, e dificuldades de acesso durante emergências de saúde, como na pandemia
de COVID-19. Em comunidades específicas, como as amazônicas, o isolamento geográfico e a falta de infraestrutura
agravam essas dificuldades. Além disso, desafios como o status de imigração e desigualdades estruturais limitam o acesso
a cuidados médicos adequados. Considerações Finais: Em suma, as barreiras de acesso à saúde para populações
vulneráveis são multifacetadas e incluem fatores econômicos, sociais e estruturais que exigem intervenções integradas e
adaptadas às necessidades específicas dessas comunidades. Para superar esses desafios, é crucial promover políticas
públicas inclusivas e equitativas.
EDUCAÇÃO EM SAÚDE: UMA FERRAMENTA VITAL NA PREVENÇÃO DE CONDIÇÕES CRÔNICAS
Authors: OLIVEIRA MARIA EMÍLIA DANTAS , ALVES ANA KARINA DA COSTA MELENDEZ , ALFAIA ARIANA DANTAS , SOUSA BÁRBARA VANESSA DOS SANTOS , MARÇAL ISMÊNIA EDWIRGES BERNARDES , SOUSA HELLIANY PIMENTEL DE , SILVA MARIA JOSÉ DA , BORGES VITÓRIA CAMILLY ROCHA , SILVA VITÓRIA CRISTINE SOUSA DA , LIMA ELAYNNE JEYSSA ALVES
Published: December 2024

Introdução: A crescente prevalência de condições crônicas representa um desafio significativo para os sistemas de saúde
em todo o mundo. Nesse contexto, os programas de educação em saúde emergem como uma estratégia fundamental para
a prevenção e manejo dessas condições. Ao fornecer informações e ferramentas necessárias para que os indivíduos adotem
estilos de vida saudáveis, esses programas visam não apenas reduzir a incidência de doenças crônicas, mas também
promover a adesão a tratamentos e autocuidado. Objetivo: Analisar a eficácia dos programas de educação em saúde na
prevenção e redução da incidência de condições crônicas. Metodologia: Trata-se de uma abrangente revisão integrativa
da literatura, conduzida em 2024 mediante consulta às respectivas bases de dados SciELO e BVS. Resultados e
Discussão: A implementação de programas de educação em saúde em indivíduos de risco para condições crônicas é
fundamental para a prevenção e redução da incidência dessas doenças. Esses programas promovem o letramento
funcional, capacitando os indivíduos a gerenciarem sua saúde, adotando estilos de vida saudáveis e aderindo ao
tratamento. Além disso, a educação em saúde fomenta a conscientização sobre a importância da prevenção e do
autocuidado, o que pode levar a uma diminuição das taxas de doenças crônicas. Intervenções educativas também abordam
barreiras socioeconômicas e culturais, ampliando o acesso a cuidados preventivos e contribuindo para melhores resultados
em saúde. Considerações Finais: A implementação de programas de educação em saúde é crucial para capacitar
indivíduos em risco, promovendo prevenção e adesão ao tratamento, o que resulta na redução da incidência de condições
crônicas e na melhoria da qualidade de vida.
Indicadores de qualidade ambiental: uma perspectiva a partir da Zona de Transição Amazônica-Cerrado, pesquisa em saúde e meio ambiente - Volume 3
Authors: Silva Maria Raimunda Chagas , Miranda Rita de Cássia Mendonça de , Silva Darlan Ferreira da , Rodrigues Eduardo Henrique Costa , Silva Fabrício Brito
Published: December 2024

A obra “Indicadores de Qualidade Ambiental: Uma Perspectiva a partir da Zona de Transição Amazônica-Cerrado-Pesquisa em saúde e meio ambiente” explora as interações entre o meio ambiente e a saúde Cultura e Sociedade, com foco nas dinâmicas da transição ecológica entre dois dos biomas mais ricos e ameaçados do planeta: Amazônia e Cerrado. A degradação ambiental nesses ecossistemas não afeta apenas a biodiversidade, mas também a qualidade de vida das populações locais, causando doenças respiratórias, dermatológicas e alimentares, além de comprometer os recursos naturais essenciais para a subsistência.
A fronteira entre a Amazônia e o Cerrado é uma região única, onde se encontram duas dos mais importantes biomas do planeta. No entanto, essa região enfrenta desafios significativos relacionados à sustentabilidade, saúde, cultura e sociedade. Este livro apresenta uma abordagem integrada para entender esses desafios e propor soluções inovadoras.
Este livro é uma leitura essencial para aqueles que buscam compreender como os ecossistemas e a saúde humana estão intrinsecamente conectados e como o futuro depende de soluções integradas que combinem sustentabilidade, ciência e políticas públicas inovadoras.
Los nombramientos magisteriales del obispado de Michoacán, 1765-1766
Authors: Cedeño Peguero María Guadalupe
Published: December 2024

Este trabajo se enfoca en el análisis y estudio de las formas de oficializar la labor docente en los tiempos novohispanos, cuando era la iglesia la que todavía tenía a su cargo la dirección y administración de la educación, en especial la de las primeras letras. Para ello es necesario resaltar la importancia que tuvieron en la transformación de la labor magisterial y el movimiento de la ilustración en el paulatino proceso de secularización social que impulsaron los borbones. El texto resalta la tarea de la llamada “ilustración temprana” que manifestó su sabiduría con sus acciones reformadoras y modernizadoras de la sociedad de su época.
Prehypertension and Hypertension among Nursing Students in Southwest Nigeria
Authors: Adegoke AO , Amole IO , Adesina SA , Durodola AO , Idowu AE , OlaOlorun AD
Published: December 2024

Background: Hypertension, also known as the "silent killer", constitutes a major threat to the health of people all over the world. It can start during adolescence and continue into adulthood. It is often difficult to diagnose early in adolescents and youths because they are otherwise healthy. Therefore, the risk of presenting with complications and target organ damage is high in them.
Objective: To determine the prevalence of prehypertension and hypertension among Nigerian nursing students.
Methods: A retrospective study of 216 students admitted into the College of Nursing between 2019 and 2021 was done. The gender, age, weight, height and blood pressure were retrieved from the medical records.
Results: The prevalence of prehypertension and hypertension were 31.0% and 2.8%, respectively. Prehypertension was higher among females and overweight students, while hypertension was higher among males and obese participants. Hypertension was significantly associated with gender and body mass index.
Conclusion: The prevalence of prehypertension was high in this study. Therefore, there is a need for regular screening and health education of young adults on prehypertension to prevent progression into hypertension in later life.
Bdellovibrio: A possible application for the control of Aeromonas species
Authors: Guadalupe Esmeralda Jimenez Castro  , Isabel Cristina Rodríguez Luna  , Alejandro Sánchez Varela
Published: December 2024

In the last decade there has been a growing increase in antimicrobial resistance, this has been due to bad practices and excessive use in the clinical and agricultural area. Aeromonas species cause infections in fish and shellfish, causing furunculosis, causing large economic losses in fish farms. In humans Aeromonas causes gastroenteritis and infections in wounds and soft tissues. According to the WHO Aeromonas is classified as a priority pathogen for the development of new strategies for its control. Bdellovibrio is a predatory bacterium that has a wide range to attack Gram-negative bacteria even greater than some phages, which represents a great potential for the control of pathogenic bacteria. In this study, ten bacteria of the genus Bdellovibrio were isolated from environmental samples (soil, water and feces of mammalian animals), all were identified within the genus Bdellovibrio, through partial sequences of the 16S rRNA gene. Their predation efficiency against Aeromonas strains of clinical and environmental origin was evaluated. All Bdellovibrio spp. isolates showed efficiency in preying on Aeromonas species. In the predation efficiency results, Bdellovibrio isolates showed a reduction in the population of Aeromonas strains after 5 to 16.5 h of their inoculation.
Evaluation of botulinum toxin type(A) as a treatment modality for migraine
Authors: Russell Mukdad Abdul-razzaq  , Huda Saad Salman  , Hadi Sajid Abdulabbas  , Mustafa Abdulrahman Abd Naji Al kinani
Published: December 2024

Botulinum toxin, recognized as one of the most potent biological toxins identified, is a neurotoxin synthesized by the bacterium Clostridium botulinum. C. botulinum produces eight antigenically distinct exotoxins (A, B, C 1 , C 2 , D, E, F and G). The aim of this study was to Understand how botulinum toxin works to prevent or alleviate migraine symptoms, Evaluate the possible complications associated with this modality and investigate the efficacy of botulinum in those with chronic or episodic migraines.
Material and Methods: A total of 15 patients (10 males and 5 females) were examined, all of them had a chronic headache and any type of migraine, at the Department of Oral and Maxillofacial surgery/Collage of Dentistry, Al-Farahidi university between February to June 2024. The study received approval from the Faculty of Dentistry administration. Each patient signed Informed Consent, also The patient will be provided with detailed information about Botox injections, including potential side effects, expected outcomes, and the importance of compliance with follow-up visits. Botulinum toxin injections ought to be administered in close proximity to the designated markings in order to prevent the inadvertent tattooing of the skin at the injection site, while simultaneously instructing patients to execute specific facial expressions. locating the superior orbital rim, and avoid giving the toxin below or near the supraorbital foramina pinching the glabellar region to fully catch the muscle, penetrating the whole muscle thickness in order to get fine results providing the toxin into the procerus muscle, frontalis, orbicularis oculi, Temporalis Muscle.
Results: It shows that 15 subjects participated in this study with 10 males (66.7%) and 5 females (33.3%) aged 25-44 years old with mean ±Standard deviation 33.67±5.97, and it shows that 5 subjects (33.33%) with cluster headache while 10 subjects (66.67%) with Migraine, it shows that 10 cases (66.67%) take 100 unit of botulin while 5 cases (33.33%) take 50 units.
Conclusion: BoNT/A was found to be effective and safe in the prophylactic treatment of chronic migraine. BoNT/A is an effective treatment that could be administered by experienced neurologists to eligible CM patients regardless of previous prophylactic treatment.
The role of inseminators in the success of artificial insemination beef cattle in Gorontalo district
Authors: Asrieana Suprianti Dunggio  , Mohamad Ikbal Bahua  , Safriyanto Dako
Published: December 2024

The research was conducted using survey method with the aim to analyze the relationship between variables of characteristics, knowledge and skills of inseminators that affect their performance in supporting the success of artificial insemination of beef cattle in Gorontalo District and the variables that play the most role in the performance of successful implementation of artificial insemination in beef cattle. This research is a qualitative and quantitative research. The subjects in this study were 26 inseminators. The source of data is primary data through questionnaires. Data analysis was done descriptively and Multiple Linear Regression Analysis. The results of the study inseminator performance together significantly influenced (P<0.05) by age factor (P<0.05).0.05) by age (X₁), length of service (X₂), characteristics (X₄) and knowledge (X₅) and significantly influenced the success of artificial insemination with the equation Y= 2.3358+0.0196X₁-0.0369X₃+0.1623X₄-0.4542X₅ (P<0.05) with R²=0.0358+0.0196X₁-0.0369X₃+0.1623X₄-0.4542X₅ (P<0.05).0.05) with R²=0.5258 and p-value=0.03459.
Advances in nanomaterials for lithium-ion batteries: Enhancing energy density and lifespan
Authors: Caleb Omata Ilabija  , Temitope Olubanjo Kehinde  , Jude Ifeanyichukwu Ishiwu  , Oluwafemi Tayo Ojo  , Shola Abayomi Ogunkanmi  , Muhammad Bolakale Salman  , Afolabi Ridwan Bello
Published: December 2024

With revolutionary gains in energy density, stability, and lifetime, nanomaterials are driving the development of lithium-ion batteries (LIBs). The need for improved performance has prompted extensive study into the incorporation of nanomaterials as LIBs power essential technology, such as portable devices and electric cars. Researchers have overcome long-standing constraints in conventional designs by introducing materials like silicon, graphene, and metal oxides into anode and cathode frameworks, leading to advances in ion diffusion rates and storage capacity. These advances equally present various limitations. One major obstacle to long-term performance is silicon's propensity to expand while charging, which can lead to structural instability. Techniques like nanostructuring and the development of hybrid composites—such as fusing graphene with metal oxides—have surfaced to solve such problems. By effectively balancing the strengths of various materials, these methods increase cycle stability and energy capacity. However, the road to an effective commercialization process remains evasive. Scalability issues, production costs, and environmental effects continue to be major obstacles that need to be addressed. This review explores the most recent developments in nanomaterials, emphasizing how they could revolutionize LIB technology and looking at the realistic measures needed to go from lab success to commercial viability. By examining these advancements, this review amplifies the critical role nanotechnology can play in influencing the development of the upcoming generation of environmentally friendly energy storage technologies.
Successful treatment of Cervical Type Cervical Spondylosis with Meridian Balancing Acupuncture: A significant case study with excellent outcomes
Authors: Massimo Bondi  , Jianqiao Fang  , Xiaomei Shao
Published: December 2024

This case report presents an office worker diagnosed with Cervical Type Cervical Spondylosis who underwent Meridian Balancing Acupuncture therapy. The patient had experienced recurrent episodes of pain and stiffness over several years, with exacerbations in the past three years, which were managed with conventional, modern medical treatments. However, these interventions did not result in long-term resolution, as symptoms consistently relapsed within a few days. Due to the increasing burden of the condition, the patient opted for acupuncture treatment and was administered a prescribed Meridian Balancing Acupuncture regimen. The treatment protocol consisted of three 30-minute acupuncture sessions, administered every other day over the course of one week. Distal acupuncture points on the limbs were selected and manipulated every 5-10 minutes. During palpation of sensitive/reactive points, as well as during needling and manipulation, the patients were instructed to gradually rotate their neck in various directions to assess symptom relief. After the initial treatment, the patient experienced complete resolution of pain and stiffness, though a mild relapse was observed before the second and third sessions. By the conclusion of the treatment course, both pain and stiffness were fully resolved. A follow-up conducted four weeks post-treatment revealed no recurrence of Cervical Spondylosis symptoms.
A Descriptive Qualitative Study on Types of Teachers' Questions in Classroom Interaction
Authors: Kakerissa Wenda Marlin
Published: December 2024

Teachersâ€™ questions have become a vital role in building a well classroom interaction. The aim of this study is to qualitatively describe about teachersâ€™ questions in building classroom interaction in teaching and learning process. A qualitative descriptive research design was done by analyzing a video recording and interview with classroom English teacher who was also one of the participants of this study. A framework that was used in this study in analyzing teachersâ€™ questions is display and referential questions and the other three types of questions (confirmation checks, comprehension checks, and clarification request) proposed by Long and Sato. The result revealed that the classroom teacher used five types of questions in building classroom interaction in teaching and learning process. Other researchers may conduct the further research on how students respond towards teachersâ€™ questions, and also to see a more detail about the influence of questioning strategy in motivating students to speak out fully in English.
HADIS SAFAR PEREMPUAN DALAM PERSPEKTIF MODERN
Authors: Istifarin Nur Annisa , Rochmawati Ida
Published: December 2024

Hadiths that prohibit women from traveling without a mahram are often understood literally, without considering the socio-historical context in which the hadiths were revealed. This understanding has sparked controversy particularly in its application in modern society, which has undergone significant changes, such as improved travel safety and advancements in transportation technology. These changes necessitate a new approach that not only acknowledges the authority of the hadith texts but also aligns them with contemporary life dynamics. This qualitative research amploys a library research method. For the analysis process, it adopts Fazlur Rahman’s hermeneutic approach known as double movement, which empahasizes the importance of contextual understanding of hadith texts by considering the circumstances of the Prophet’s era nad their relevance in contemporary conditions. The findings reveal that the prohibition of women traveling without a mahram in the hadith was a response to the socio-historical conditions of that time, such as security concerns, travel risk, and the patriarchal culture that dominated Arab society. In modern contexts, these factors have significantly changed, especially with the advent of transportation technology, improved travel safety, and shifting social norms that support gender equality. Therefore, a literal approach is no longer relevant for rigid application. This study asserts that using Fazlur Rahman’s contextual approach allows these hadiths to be reinterpreted, resultingin a more relevant and inclusive understanding.
MATERIALISME DALAM TAFSIR SAYYID QUTB
Authors: Utami Devi Aulia , Rusli Ris’an , Farsyad Ahmad Farid
Published: December 2024

This article discusses Sayyid Qutb's views on materialism, especially in the context of his interpretation of Surah Ali Imran, verse 14. This verse mentions human love for the world, including wealth, women, children, and other worldly pleasures. The method used in this article is a qualitative approach with a literature review. For the analytical approach, the article employs a tahlili (analytical) method, which allows the author to explore a verse in-depth. Through this study, the article aims to reveal how Qutb's *Tafsir Fi Zhilalil Qur'an* provides relevant insights into the dangers of materialism in modern life and how Muslims should balance their worldly life with the hereafter. The research findings show that in his tafsir, Sayyid Qutb criticizes excessive love for the world as a form of materialism that can divert Muslims from their higher purpose in life, which is to seek Allah’s pleasure and the happiness of the hereafter. Qutb emphasizes the importance of awareness that love for the world must remain within reasonable limits so that it does not hinder one's focus on spiritual values and righteous deeds.
Students' Perceptions of TOEIC Training for Improving Listening and Reading Scores
Authors: Miftachudin Miftachudin , Utari Dian Asa , Puspandari Lusia Eni , Erawati Ika , Sari Eka Dyah Puspita , Fathoni Muhammad Rofiful
Published: December 2024

This research aims to distinguish students' perceptions of the TOEIC training given by lecturers for final semester students to help them to achieve the passing grade determined by the campus as a graduation requirement. This research is a qualitative descriptive that revealed the reality of TOEIC training by analyzing relevant data. The selection of research subjects was carried out using a purposive sampling technique on students who had received TOEIC training. Data collection uses a closed questionnaire method which is applied to 186 students from 11 study programs who join TOEIC training. In depth interview was also conducted toward 30 students. The research questionnaire consists of 2 parts, namely: Perception of Learning Quality and Perception of benefits to TOEIC training. The result of this research shows that students have positive perception toward TOEIC training and they agree TOEIC training can improve their listening and reading score. Meanwhile, the interview reveals that students get benefit more from integrated skills approach using authentic material than just simulation and structured practices of TOEIC. This results give insights on future TOEIC Training about its effectiveness to improve students’ English proficiency as well as proposing the best method used in the future training of TOEIC.
Taze ve Kuru Agaricus bisporus’da Polifenol Oksidaz Enzimlerinin Karşılaştırılması
Authors: Demir Dudu , Eken Cafer
Published: December 2024

Agaricus bisporus (J.E. Lange ) Imbach, dünyada olduğu gibi ülkemizde de ticari olarak kültürü yapılan en önemli mantar türlerinden biridir. Polifenol oksidaz (PPO), meyve ve sebzelerde yaygın olarak bulunan fenolik bileşiklerin oksidasyonunu katalizleyerek, onları o-kinonlara yükseltgeyen ve bunların polimerizasyonu sonucu esmerleşmeyi yapan kahverengi melanin pigmentlerinin oluşumuna yol açan bir enzimdir. PPO enziminin katalizlediği enzimatik kararma reaksiyonları ürünün tat, görünüm ve besin değerini düşürdüğünden istenmemektedir. Bu çalışmada, A. bisporus’un taze ve kuru halinin PPO enziminin karşılaştırılması amaçlanmıştır. Taze ve kuru A. bisporus’da mevcut olan PPO enzimlerinin ekstraksiyonu, saflaştırılması (amonyum sülfat çöktürmesi, diyaliz ve afinite kolon kromatografisi) ve karakterizasyonu yapılmıştır. Saflaştırmada afinite jeli olarak Sepharose 4B-L-tirozin-p-aminobenzoik asit kullanılmıştır. Saflaştırılan taze ve kuru A. bisporus’daki PPO aktiviteleri spektrofotometrik yöntem kullanılarak değerlendirilmiştir. PPO enzim aktivitelerinin belirlenmesi için substrat olarak katekol kullanılmıştır. Çalışma sonucunda, A. bisporus’un taze ve kuru hallerinin PPO aktivitelerinin farklı olduğu tespit edilmiştir. Bu araştırma, taze ve kuru A. bisporus’daki PPO enzimlerinin karşılaştırılmalı olarak incelendiği ilk çalışmadır.
Design and development of quetiapine fumarate nanosuspension by media milling method
Authors: Parmar Komal , Patel Mehul , Sorathia Kishorkumar , Soni Tejal
Published: December 2024

Introduction: The critical and complex properties of Biopharmaceutics Classification System Class II quetiapine fumarate active pharmaceutical ingredient molecules that complicate effective oral delivery of these active pharmaceutical ingredients include low aqueous solubility and reduced bioavailability.
Objective: The objective of this investigation is to develop a nanosuspension formulation of quetiapine fumarate using media milling techniques to effectively reduce particle size and enhance dissolution rate.
Method: Quetiapine fumarate Nano suspensions were prepared by the media milling method. The milling process was optimized by studying the effects of critical process parameters on the size of nanosuspension using a factorial design approach. The prepared nanosuspension is subjected to various characterization techniques such as Particle size, Zeta Potential, differential scanning calorimetry, X-ray powder diffraction, scanning electron microscopy, and in vitro dissolution rate assessment.
Results: The obtained results demonstrate that the average particle size of the prepared nanosuspensions is 225 nm with a Polydispersity index of 0.530, while the average Zeta potential is -38.2 mv. The crystalline structure of quetiapine fumarate nano-suspension is evident from differential scanning calorimetry and X-ray powder diffraction.
Conclusion: The dissolution rate of the nanosuspension is significantly faster than that of pure Quetiapine Fumarate, and the Cumulative drug release (%) of nanosuspension is higher than that of pure Quetiapine Fumarate , indicating that the use of nanotechnology can considerably enhance the dissolution rate.
Analysis of current regulatory requirements for the quality of live bacterial vaccines and prospects for the improvement of vaccine quality control methods
Authors: Nemirovskaya T. I. , Kasina I. V. , Aleksandrova N. V. , Alekseeva S. A.
Published: December 2024

INTRODUCTION. Currently, there are live bacterial vaccines (LBVs) for the prevention of tuberculosis and particularly dangerous infections, such as plague, tularaemia, anthrax, and brucellosis. LBVs provide reliable and long-lasting protection. The high effectiveness of LBVs is due to their ability to mimic natural infections. Despite significant differences in LBV compo­sitions, indications, and production species, the applicable quality control approaches share some common principles. At the same time, there are significant differences in methodological approaches to the assessment of a number of quality attributes, and some of these approaches require improvement and/or optimisation.

AIM. This study aimed to analyse current regulatory requirements for the quality of LBVs having different compositions and indications, to identify the quality attributes of LBVs with the associated quality control methods in need of improvement, and to explore promising pathways for further development in this area.

DISCUSSION. The review of regulatory standards and manufacturer specifications identified several quality attributes common to all LBVs. Vaccine identity was considered a key quality attribute. Motivated by the development of novel national diagnostic test systems, the authors analysed the performance of these test systems in practice to determine their potential for the identification of bacterial vaccines. In particular, immunochromatographic and serological techniques were successfully applied to the quality control of the tularaemia vaccine, a serological method was deemed suitable for brucellosis vaccines, and immunochromatography was recommended for plague and anthrax vaccines. A multiplex PCR method passed practical testing to be used for the quality control of BCG vaccines with reagents from Russian manufacturers. Flow cytometry was considered a promising technique for improving the quality control of LBVs in terms of viable units (tuberculosis and plague vaccines) and immunogenicity (plague vaccines).

CONCLUSIONS. This analysis of regulatory requirements highlighted problematic issues related to the standardised quality attributes of LBVs and methods for their assessment. The literature review results and the authors’ own data indicate promising directions for improving the methodology of LBV quality assessment. One of these promising directions is the use of Russian-made commercial test systems for LBV identification.
Определение флавоноидного состава экстракта из плодов софоры японской и оценка его церебропротекторной активности
Authors: Сайбель Ольга Леонидовна , Гуляев Сергей Миронович , Радимич Андрей Иванович , Ферубко Екатерина Владимировна , Даргаева Тамара Дарижаповна
Published: December 2024

Целью настоящего исследования явилось изучение состава и содержания флавоноидов экстракта плодов софоры японской, а также оценка его церебропротекторной и антиоксидантной активности. В результате проведенного исследования методом ВЭЖХ-УФ-МС в экстракте идентифицированы гликозиды кемпферола, кверцетина, генистеина и изорамнетина. Химический анализ показал, что содержание суммы флавоноидов составляет 50,82 ± 1,02 %. На модели ишемии головного мозга на белых крысах установлено, что экстракт в максимальной экспериментальной дозе 200 мг/кг оказывает церебропротекторное действие: выживаемость составила 67 % при контрольном значении 20 %, а неврологический дефицит был меньше на 26,5 % (p ≤ 0,05) по сравнению с контролем. С помощью ДФПГ-теста показано, что экстракт проявляет выраженную антиоксидантную активность: показатель IC50 составил 206,97 ± 22,5 мкг/мл.
Изучение условий кристаллизации полиморфных форм (S)-малата кабозантиниба
Authors: Земцов Артём Андреевич , Курохтин Александр Алексеевич , Чижов Павел Сергеевич , Бабак Николай Леонидович , Шайхутдинова Анна Разифовна , Константинов Игорь Олегович , Афанасьев Юрий Дмитриевич , Алашеев Антон Юрьевич
Published: December 2024

Влияние растворителя и условий кристаллизации на образование различных полиморфных модификаций (S)-малата кабозантиниба исследовано с применением метода порошковой рентгеновской дифракции. Выделена и идентифицирована с помощью рентгенофазового анализа новая полиморфная модификация (S)-малата кабозантиниба. Полученные в работе результаты могут быть полезны при разработке технологии производства активных фармацевтических субстанций.