bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Demographic and Economic Change on the Australian Generational Economy: Financial Sustainability, Intergenerational Inequality, and Material Living Standards
Authors: Rice James Mahmud , Wilson Tom , Temple Jeromey B. , McDonald Peter
Published: June 2022

The generational economy—which is that aspect of the economy that pertains to the economic activities of, and the economic relationships between, different ages and generations—can be evaluated on the basis of a number of different criteria. The most critical of these include the financial sustainability of the generational economy, the intergenerational inequality that the generational economy creates, and the material living standards associated with the generational economy. How the generational economy performs in terms of these three criteria is, moreover, shaped by underlying processes of demographic and economic change. This paper examines how the Australian generational economy can be expected to perform in coming decades in terms of financial sustainability, intergenerational inequality, and material living standards. How the performance of the Australian generational economy is shaped by variations in fertility, mortality, overseas migration, and labour-income growth is also assessed. The results reported in the paper indicate that, because of population aging, consumption can only grow at a substantially lower rate than labour income if financial sustainability is to be maintained. These results also suggest that increasing overseas migration is a distinctly useful policy tool for meeting the challenges posed by population aging, since increasing overseas migration both increases material living standards and decreases intergenerational inequality.
COVID-19 Preventive Measures in Northern California Jails: Perceived Deficiencies, Barriers, and Unintended Harms
Authors: Liu Yiran E. , LeBoa Christopher , Rodriguez Marcela , Sherif Beruk , Trinidad Chrisele , del Rosario Michael , Allen Sophie , Clifford Christine , Redding Jennifer , Chen Wei-ting , Rosas Lisa G. , Morales Carlos , Chyorny Alexander , Andrews Jason R.
Published: June 2022

Background

Carceral facilities are high-risk settings for COVID-19 transmission. Little is known about the hidden burden of infection or practical barriers to infection control in these settings, especially in jails. There is also limited research on the mental health impacts of the pandemic among people living and working in carceral facilities.

Methods

Between July 8, 2020 and April 30, 2021, we performed SARS-CoV-2 rapid antibody testing and administered a questionnaire among residents and staff of four Northern California jails. We utilized multivariable logistic regression, adjusting for demographic and carceral characteristics, to analyze factors associated with prior infection, including perceived likelihood of prior infection and access to new masks. We additionally assessed the implementation of, perceptions toward, and impacts of COVID-19 policies in practice. We engaged stakeholder representatives, including incarcerated individuals, to guide study design, procedures, and results interpretation.

Results

We enrolled 788 jail residents and 380 jail staff. Nearly half of residents and two-thirds of staff who were antibody-positive had not previously tested positive for COVID-19. Among residents without a prior COVID-19 diagnosis, antibody positivity was significantly associated with perceived likelihood of prior infection (adjusted OR = 8.9; 95% CI, 3.6–22.0). Residents who had flu-like illness in jail cited inadequate responses to reported illness and deterrents to symptom reporting, including fears of medical isolation and perceptions of medical neglect. Residents also disclosed deficient access to face masks, which was associated with antibody positivity (adjusted OR = 13.8, 95% CI, 1.8–107.0). Worsened mental health was pervasive among residents, attributed not only to fear of COVID-19 and unsanitary jail conditions but also to intensified isolation and deprivation due to pandemic restrictions on in-person visitation, programs, and recreation time.

Conclusion

Carceral settings present significant challenges to maintaining infection control and human rights. Custody officials should work diligently to transform the conditions of medical isolation, which could mitigate deterrents to symptom reporting. Furthermore, they should minimize use of restrictive measures like lockdowns and suspension of visitation that exacerbate the mental health harms of incarceration. Instead, custody officials should ensure comprehensive implementation of other preventive strategies like masking, testing, and vaccination, in conjunction with multisector efforts to advance decarceration.
“We Speak the Same Language, but They Don't Understand Us.” Use and Abuse of Culturalism in Medical Care for Central American Migrants in Transit Through Mexico
Authors: Stoesslé Philippe
Published: June 2022

This article deals with cultural stereotypes toward Central American migrants in the Mexican healthcare system, which lead to the naturalization of the supposed cultural characteristics of these new users. Based on 21 interviews of health and administrative staff in the state of Nuevo Leon (northeastern Mexico), it shows the first recourse to culturalist explanations to describe any phenomenon related to migrants' health. According to this perspective, the health of migrants, their relation to illness, and their patterns of seeking healthcare would be mainly determined by characteristic cultural traits, which justify their penurious attendance at health centers, and their low adherence to treatments. The culturalist explanation of migrants' health behaviors may influence the care they receive, as well as their adherence to treatment, which ultimately reinforces the health inequalities initially highlighted. This culturalist excess is partly explained by the incorrect understanding of the directives of health authorities in favor of the integration of an intercultural perspective in healthcare. Despite some ongoing training in this area, it does not seem sufficient to correct this situation effectively.
Cost-Effectiveness Analysis of Pembrolizumab Plus Chemotherapy vs. Chemotherapy Alone as First-Line Treatment in Patients With Esophageal Squamous Cell Carcinoma and PD-L1 CPS of 10 or More
Authors: Zheng Zhiwei , Lin Jingrong , Zhu Huide , Cai Hongfu
Published: June 2022

Background

This study aimed to analyze the economics of pembrolizumab plus chemotherapy as first-line treatment in patients with esophageal squamous cell carcinoma (ESCC) and programmed cell death-Ligand 1 (PD-L1) combined positive score (CPS) of 10 or more in China.

Methods

Based on the advanced ESCC of the KEYNOTE-590 clinical trial data, a Markov model was performed to simulate the clinical course and evaluate the patient's total lifetime, total costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio (ICER) for pembrolizumab plus chemotherapy (cisplatin and 5-fluorouracil) vs. chemotherapy alone in first-line treatment of ESCC and PD-L1 CPS of 10 or more. Utility values and direct costs related to the treatments were gathered from the published literature data. One-way and probabilistic sensitivity analyses were conducted to check the stability of the model.

Results

The baseline analysis indicated that the incremental effectiveness and cost of pembrolizumab plus chemotherapy vs. chemotherapy alone added 1.23 QALYs and resulted in an incremental cost of $51,320.22, which had an ICER of $41,805.12/QALY, higher than the willingness-to-pay (WTP) threshold of China ($37,663.26/QALY). The sensitivity analysis demonstrated that the ICERs were most sensitive to the cycle of pembrolizumab used and the cost of pembrolizumab.

Conclusion

The result of our present analysis suggests that the addition of pembrolizumab plus chemotherapy as first-line treatment might not be cost-effective for patients with ESCC and PD-L1 CPS of 10 or more in China.
Design and Cross-Cultural Invariance of the COVID-19 Vaccine Conspiracy Beliefs Scale (COVID-VCBS) in 13 Latin American Countries
Authors: Caycho-Rodríguez Tomás , Valencia Pablo D. , Ventura-León José , Vilca Lindsey W. , Carbajal-León Carlos , Reyes-Bossio Mario , White Michael , Rojas-Jara Claudio , Polanco-Carrasco Roberto , Gallegos Miguel , Cervigni Mauricio , Martino Pablo , Palacios Diego Alejandro , Moreta-Herrera Rodrigo , Samaniego-Pinho Antonio , Lobos-Rivera Marlon Elías , Figares Andrés Buschiazzo , Puerta-Cortés Diana Ximena , Corrales-Reyes Ibraín Enrique , Calderón Raymundo , Tapia Bismarck Pinto , Arias Gallegos Walter L. , Petzold Olimpia
Published: June 2022

Aims

Over the past 2 years, the vaccine conspiracy beliefs construct has been used in a number of different studies. These publications have assessed the determinants and outcomes of vaccine conspiracy beliefs using, in some cases, pooled data from different countries, and compared the results across these contexts. However, studies often do not consider measurement invariance as a necessary requirement for comparative analyses. Therefore, the aim of this study was to develop and evaluate the cross-cultural MI of the COVID-19 Vaccine Conspiracy Beliefs Scale (COVID-VCBS) in 12 Latin American countries.

Methods

Confirmatory factor analysis, item response theory analysis and alignment method were applied to test measurement invariance in a large number of groups.

Results

The COVID-VCBS showed robust psychometric properties and measurement invariance for both factor loadings and crosstabs. Also, a higher level of acceptance of conspiracy beliefs about vaccines is necessary to respond to higher response categories. Similarly, greater acceptance of conspiracy beliefs about COVID-19 vaccines was related to a lower intention to be vaccinated.

Conclusion

The results allow for improved understanding of conspiracy beliefs about COVID-19 vaccines in the countries assessed; furthermore, they provide researchers and practitioners with an invariant measure that they can use in cross-cultural studies in Latin America. However, further studies are needed to test invariance in other countries, with the goal of developing a truly international measure of conspiracy beliefs about COVID-19 vaccines.
Challenging Health Service Delivery Models to Improve Access to Physical Therapy in Rural, Remote and Northern Communities
Authors: Smith Liris P. R.
Published: June 2022

Effective rural, remote and northern physical therapy services are an important component of health care. Providing these services with limited financial and human resources can present many challenges. Indigenous communities also have unique needs that must be considered when providing health care. Most current service delivery models are based in Western medicine practices and most often, do not account for the local, political, cultural and spiritual needs of communities. In this perspective article, I discuss the challenges of providing these services in rural Yukon to many small First Nation communities. Relationship building is paramount to effective and meaningful health care programs, and this means a change in current practice approaches. We need to challenge the delivery models and be open to other ways of knowing, beyond the Western biomedical approach that is the foundation of our profession. It is imperative that physical therapists, health care providers and funders seek new and innovative ways to provide services to the rural, remote and northern communities while ensuring a culturally humble approach.
Probing Prolamin-Anthocyanin Interactions for the Rational Design of Plant-Based Encapsulation Systems
Authors: Salamun Joshua W. , Chen Aicheng , Corradini Maria G. , Joye Iris J.
Published: June 2022

Plant proteins are increasingly focused upon as alternatives to animal-derived macromolecules for the encapsulation of bioactives. The rational design of encapsulation carriers should be based on a solid understanding of the interactions between the proteins and bioactives. Encapsulation technology for food applications has focused predominantly on the protection and controlled release of hydrophobic bioactives. For hydrophilic molecules, although not less important from a nutritional and health perspective, significantly fewer encapsulation systems have been explored, designed and described. As hydrophilic molecules tend to partition into the aqueous food matrix, it is even more crucial to understand and to be able to modulate the interactions between the hydrophilic bioactive and the encapsulating matrix material in food relevant conditions. Therefore, examining the nature of the interactions between anthocyanins (ACNs), a hydrophilic bioactive, and prolamin plant proteins (gliadin, hordein, secalin, and avenin) is timely. These interactions were examined using steady-state and time-resolved luminescence spectroscopy techniques. The ACN-induced quenching of the prolamins intrinsic fluorescence emission did not follow a linear Stern-Volmer relationship, but rather displayed an upward curvature for all the prolamins tested. Hence, both static and dynamic quenching likely occurred in the prolamin-ACN systems. The quenching mechanism was further explored based on the changes in fluorescence lifetime as ACN concentration increased. As the independent lifetimes of the prolamin-ACN combinations did not decrease discernibly as a function of ACN concentration, static quenching is presumably the predominant quenching mechanism. The thermodynamic parameters revealed that the interactions between secalin- and avenin-ACN are mainly driven by the hydrophobic effect, while those between gliadin- and hordein-ACN are dominated by ionic interactions. Zeta-potential measurements support the dominant ionic interactions found for gliadin and hordein. The insights gained in this research will serve as a sound basis for further studies focusing on matrix selection with regard to creating performant encapsulation systems for ACNs.
Trade-Off Between Schooling and Labor for Children: Understanding the Determinative Factors Among Rural Households in Bangladesh
Authors: Islam Rafiqul , Hoque Md Mahmudul
Published: June 2022

This research is concerned with understanding the factors behind the trade-off between child labor and child schooling, given the well-documented links between the two. It examines parents' behavior in their decision-making on their children's schooling or practicing child labor. Depending on qualitative research methods including 28 semi-structured interviews and two focus group discussions conducted in the rural areas of Bangladesh in 2020, this study reveals the following: subsistence needs compel households, particularly the ultra-poor and the female-headed, to trade off child labor with schooling; due to higher demand of labor, parents engage their children into work instead of schooling; parents of labor-intensive occupations tend to trade off child labor with schooling; sexual division of labor remains obvious; finally, credit constraints and cultural beliefs have negative impacts on parental decision-making on child schooling. Interventions aiming to reduce child labor and increase schooling in these rural areas must remain mindful of the socio-economic and cultural needs.
A New Parameter of Hip Instability in Developmental Dysplasia of the Hip (DDH): Teardrop Distance
Authors: Yang Guoyue , Zhang Zhendong , Hou Xiaobin , Luo Dianzhong , Cheng Hui , Xiao Kai , Liu Hui , Zhang Hong
Published: June 2022

Background

Hip instability is one of the etiologies of accelerated onset of osteoarthritis in developmental dysplasia of the hip (DDH). There are some radiological parameters for hip instability in hip dysplasia like broken shenton’s line, elevated acetabular index, reduced lateral center edge angle (LCEA), upsloping lateral sourcil. We have discovered a new index of teardrop distance (TD) for assessing instability. Herein, we hypothesized that increased TD could be used as evidence of hip instability in DDH patients, which we verified using TD as an auxiliary diagnostic parameter for DDH, from supine to standing position.

Methods

Female DDH patients undergoing Bernese periacetabular osteotomy (PAO) were enrolled in the DDH group, and normal female volunteers were in the control group. Anteroposterior radiographs of the pelvis in the supine and standing positions were taken, and LCEA, Tönnis angle (TA), sharp angle (SA), and TD were tested using Stata software to analyze the changes between supine and standing anteroposterior pelvic radiographs.

Results

There were 26 female volunteers with 52 hips in the control group: supine TD 6.80 ± 0.98 mm, standing TD 6.65 ± 1.3 mm (P > 0.05). A total of 78 patients with 135 hips were included in the DDH group: supine TD 10.51 ± 3.50 mm, standing TD 10.93 ± 4.23 mm (P < 0.05). In either supine or standing position, TD in the DDH group was significantly wider than that in the control group (P < 0.05). In the DDH group, TD was correlated with TA and LCEA (rp 0.494–0.588, P < 0.05); TD was not correlated with SA, weight, or BMI (P > 0.05). There was a weak correlation between TD difference and standing LCEA (rp −0.276, P < 0.05).

Conclusion

TD > 10 mm was a common imaging feature of DDH. It increased from supine to standing position, thus indicating hip instability in DDH patients. The hip parameters of both positions should be compared, fully considering the factors of hip stability.
A Narrative Review of Postoperative Anticoagulation Therapy for Congenital Cardiac Disease
Authors: Boucher Alexander A. , Heneghan Julia A. , Jang Subin , Spillane Kaitlyn A. , Abarbanell Aaron M. , Steiner Marie E. , Meyer Andrew D.
Published: June 2022

Congenital heart disease encompasses a range of cardiac birth defects. Some defects require early and complex surgical intervention and post-operative thromboprophylaxis primarily for valve, conduit, and shunt patency. Antiplatelet and anticoagulant management strategies vary considerably and may or may not align with recognized consensus practice guidelines. In addition, newer anticoagulant agents are being increasingly used in children, but these medications are not addressed in most consensus statements.

This narrative review evaluated the literature from 2011 through 2021 on the topic of postoperative thromboprophylaxis after congenital heart disease operations. The search was focused on the descriptions and results of pediatric studies for replacement and/or repair of heart valves, shunts, conduits, and other congenital heart disease operations. Wide variability in practice exists and, as was true a decade ago, few randomized controlled trials have been conducted. Aspirin, warfarin, and perioperative heparin remain the most commonly used agents with varying dosing, duration, and monitoring strategies, making comparisons difficult. Only recently have data on direct oral anticoagulants been published in children, suggesting evolving paradigms of care. Our findings highlight the need for more research to strengthen the evidence for standardized thromboprophylaxis strategies.
Factors Affecting the Postoperative Bowel Function and Recurrence of Surgery for Intestinal Deep Endometriosis
Authors: Xu Ping , Wang Jianzhang , Zhang Yanan , Zhu Libo , Zhang Xinmei
Published: June 2022

Objective

This study aims to evaluate the factors associated with complications and long-term results in the surgical treatment of intestinal deep endometriosis and to figure out the optimized treatment measures for bowel endometriosis.

Methods

A retrospective study was performed in a single center in China. Medical charts were reviewed from 61 women undergoing surgical treatment for bowel endometriosis between January 2013 and August 2019 in the Department of General Gynecology, Women’s Hospital School of Medicine Zhejiang University. Multivariate regression analysis was utilized to investigate the impact of the stages of endometriosis and surgical steps (independent risk factors) on complications (and postoperative bowel dysfunction). The clinical characters, surgical procedures, postoperative treatment, complications, and recurrence rate were summarized and analyzed by using Lasso regression.

Results

Surgery type was the most important independent risk factor related to postoperative abnormal defecation in intestinal deep endometriosis patients (P < 0.05, OR = 34.133). Infection is the most important independent risk factor related to both postoperative complications (OR = 96.931) and recurrences after conservative surgery (OR = 4.667). Surgery type and age were significantly related to recurrences after conservative surgery.

Conclusions

We recommended conservative operation especially full-thickness disc excision to improve the quality of life of intestinal deep endometriosis patients. In addition, prevention of infection is very important to reduce the postoperative complications rate and the recurrence rate.
Trends in Intake and Outcome Data From U.S. Animal Shelters From 2016 to 2020
Authors: Rodriguez Jeffrey R. , Davis Jon , Hill Samantha , Wolf Peter J. , Hawes Sloane M. , Morris Kevin N.
Published: June 2022

In this retrospective, exploratory study, intake and outcome data were compiled from 1,373 U.S. animal shelters for which such data were reported consistently across a five-year study period (2016–2020). Linear regression analysis was used to examine the five-year trends and the impacts of the first year of the COVID-19 pandemic (2020) on the overall trends in intake and outcomes in U.S. animal shelters. The results of the analysis reveal that total intake and euthanasia for both dogs and cats significantly decreased over the study period. The adoption, return-to-owner, return-to-field, and transfer (for cats) categories as a percentage of intake all showed significant increases. Live release rates as a function of total intakes and total outcomes for both dogs and cats showed significant increases over the study period. The findings from this study address a critical gap in the field by summarizing emerging trends at the national level in how cats and dogs are being served in U.S. animal shelters.
Dietary Macroalgae Saccharina japonica Ameliorates Liver Injury Induced by a High-Carbohydrate Diet in Swamp Eel (Monopterus albus)
Authors: Yu Chuanqi , Wang Lu , Cai Wanghe , Zhang Wenping , Hu Zhonghua , Wang Zirui , Yang Zhuqing , Peng Mo , Huo Huanhuan , Zhang Yazhou , Zhou Qiubai
Published: June 2022

A high-carbohydrate diet lowers the rearing cost and decreases the ammonia emission into the environment, whereas it can induce liver injury, which can reduce harvest yields and generate economic losses in reared fish species. Macroalgae Saccharina japonica (SJ) has been reported to improve anti-diabetic, but the protective mechanism of dietary SJ against liver injury in fish fed a high-carbohydrate diet has not been studied. Therefore, a 56-day nutritional trial was designed for swamp eel Monopterus albus, which was fed with the normal diet [20% carbohydrate, normal carbohydrate (NC)], a high carbohydrate diet (32% carbohydrate, HC), and a HC diet supplemented with 2.5% SJ (HC-S). The HC diet promoted growth and lowered feed coefficient (FC), whereas it increased hepatosomatic index (HSI) when compared with the NC diet in this study. However, SJ supplementation increased iodine contents in muscle, reduced HSI, and improved liver injury, such as the decrease of glucose (GLU), total bile acid (TBA), and alanine aminotransferase (ALT) in serum, and glycogen and TBA in the liver. Consistently, histological analysis showed that SJ reduced the area of lipid droplet, glycogen, and collagen fiber in the liver (p < 0.05). Thoroughly, the underlying protective mechanisms of SJ supplementation against HC-induced liver injury were studied by liver transcriptome sequencing coupled with pathway analysis. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the differentially expressed genes (DEGs), such as the acetyl-coenzyme A synthetase (acss1), alcohol dehydrogenase (adh), interferon-induced protein with tetratricopeptide repeats 1 (ifit1), aldo-keto reductase family 1 member D1 (akr1d1), cholesterol 7-alpha-monooxygenase (cyp7a1), and UDP-glucuronosyltransferase (ugt), indicated that the pathway of glycolysis/gluconeogenesis was the main metabolic pathway altered in the HC group compared with the NC group. Meanwhile, hepatitis C, primary BA biosynthesis, and drug metabolism-cytochrome P450 were the three main metabolic pathways altered by SJ supplementation when compared with the HC group. Moreover, the BA-targeted metabolomic analysis of the serum BA found that SJ supplementation decreased the contents of taurohyocholic acid (THCA), taurochenodeoxycholic acid (TCDCA), taurolithocholic acid (TLCA), nordeoxycholic acid (NorDCA), and increased the contents of ursocholic acid (UCA), allocholic acid (ACA), and chenodeoxycholic acid (CDCA). In particular, the higher contents of UCA, ACA, and CDCA regulated by SJ were associated with lower liver injury. Overall, these results indicate that the 2.5% supplementation of SJ can be recommended as a functional feed additive for the alleviation of liver injury in swamp eel-fed high-carbohydrate diets.
Animal Welfare and Resistance to Disease: Interaction of Affective States and the Immune System
Authors: Düpjan Sandra , Dawkins Marian Stamp
Published: June 2022

Good management and improved standards of animal welfare are discussed as important ways of reducing the risk of infection in farm animals without medication. Increasing evidence from both humans and animals suggests that environments that promote wellbeing over stress and positive over negative emotions can reduce susceptibility to disease and/or lead to milder symptoms. We point out, however, that the relationship between welfare, immunity, and disease is highly complex and we caution against claiming more than the current evidence shows. The accumulating but sometimes equivocal evidence of close links between the brain, the gut microbiome, immunity, and welfare are discussed in the context of the known links between mental and physical health in humans. This evidence not only provides empirical support for the importance of good welfare as preventative medicine in animals but also indicates a variety of mechanisms by which good welfare can directly influence disease resistance. Finally, we outline what still needs to be done to explore the potential preventative effects of good welfare.
Correction: Filion, G.J. Analytic Combinatorics for Computing Seeding Probabilities. Algorithms 2018, 11, 3
Authors: Filion Guillaume J.
Published: June 2022

The author wishes to make the following correction to this paper [...]
Design of a Panoramic Scanning Device Based on a Piezoelectric Ceramic Stack Actuator and Friction Transmission
Authors: Dai Minpeng , Ding Hao , Huang Chenwei , Zhu Yi , Wang Ming
Published: June 2022

In view of the complex structure and inaccurate positioning capabilities of the existing panoramic scanning system, a panoramic scanning device based on a piezoelectric ceramic stack actuator and friction transmission was designed. In our model, the output displacement of the piezoelectric ceramics is amplified by a bridge-type flexure hinge and applied to a shaft by friction to achieve panoramic scanning imaging. The mathematical model of the device was established, and the working characteristics were analyzed. The analysis demonstrated that the linear displacement increment of the shaft is a superposition. A modality simulation was performed, and the simulation results show that the designed device works normally at a frequency of 511.5 Hz. The test results indicated that the displacement of the actuator can reach 6 μm at an input voltage of 100 V. Moreover, the laser scanning results showed that the designed device can perform panoramic scanning imaging, which meets the requirements for use on the high-speed imaging system.
Efficient Modeling of Heat Conduction across Thin Surface Coatings on 3D Anisotropic Substrate
Authors: Shiah Yui-Chuin , Hwang Po-Wen , Hematiyan Mohammad-Rahim , Tuan Nguyen
Published: June 2022

In aerospace applications, surface coatings have been widely applied for variouspurposes. One typical example is the use of thermal barrier coating (TBC) applied on anisotropic substrate for enhancing the heat resistance of the substrate under severe operational environments. Numerical modeling of thin coatings usually present difficulties for most techniques, due to their dimensional orders being far below that of the substrate. This paper presents a numerical methodology to efficiently model the heat conduction across thin layered coatings on 3D, generally anisotropic, media by the boundary element method (BEM). In the modeling, singularities of the surface-integrals are weakened by using Green’s Second Identity, where a newly introduced function is solved by the finite volume method. Using the proposed approach, the heat conduction problem can be efficiently analyzed, despite the great difference in dimensional orders in comparison with that of the substrate beneath, by simply employing very coarse surface meshes. Such analysis shows great efficiency in calculating the nearly singular boundary integrals for the modeling. Finally, two benchmark examples of thermal barrier coatings are analyzed to illustrate the effectiveness of this approach.
Dynamics of Drying Turmeric Rhizomes (Curcuma longa L.) with Respect to Its Moisture, Color, Texture and Quality
Authors: Saha Gobinda , Sharangi Amit Baran , Upadhyay Tarun Kumar , Al-Keridis Lamya Ahmed , Alshammari Nawaf , Alabdallah Nadiyah M. , Saeed Mohd
Published: June 2022

Drying involves removing moisture from food. Therefore, to preserve the phenolic and bioactive compounds such as curcumin, dimethoxy curcumin and bisdemethoxi curcumin, etc., an efficient drying method is considered necessary. The primary drying methods are sun drying, hot air oven drying and fluidized bed drying. Traditional drying methods result in the loss of volatile oil (up to 25%) by evaporation and destruction of some light-sensitive oil constituents. Three methods of drying Turmeric with pretreatments boiled/unboiled and whole/sliced (2.5 cm long) were compared on physical and quality parameters. Texture analysis from sundry sliced boiled rhizomes achieved maximum peak force (45.40 kg), which was an indication of maximum uniform drying. Moisture content was strongly and significantly associated with drying time in different drying methods. Out of the three drying methods, in general, the sun drying showed a declining trend of L*, a* and b* values with drying time. Whereas a slower rate of decrease in L*, a* and b* values was predominant in the oven dry method. Interestingly, in the case of the fluidized method, almost static L*, a* and b* values were measured at 3 h of drying onwards after a declining trend of those values. In the case of sun and oven drying, the hue angle reached its peak at the fourth hour of drying, then gradually declined up to final drying. However, for fluidized bed drying, it had a continuous declining trend for other parameters such as chroma and total color change; there was a sharp decreasing trend for all throughout. Turmeric whole boiled dried in the sun produced the maximum curcumin (5.82%) and the sliced boiled ones produced the maximum oleoresin (8.10%), indicating good quality powdered product among all other drying treatments. Considering all the aspects, it is recommended that sun drying should be followed in post-harvest operations, as it produces a quality powder with comparatively more curcumin, despite its longer drying time.
Treatment of Winter Wheat (Triticum aestivum L.) Seeds with Electromagnetic Field Influences Germination and Phytohormone Balance Depending on Seed Size
Authors: Cecchetti Daniele , Pawełek Agnieszka , Wyszkowska Joanna , Antoszewski Marcel , Szmidt-Jaworska Adriana
Published: June 2022

Electromagnetic field (EMF) and its effect on crop plant growth and their quality parameters is increasingly gaining the interest of researchers in agronomic science. However, the exact mechanism of EMF action in plant cells is still unclear. Among the completely unexplored parameters is the relationship between the EMF effects and the seed size. Thus, the EMF effect was analyzed in winter wheat seeds categorized into two size groups, small and big. The study focused on the germination kinetics, early growth parameters, and phytohormone concentrations (indole-3-acetic acid, IAA and abscisic acid, ABA) in seeds, roots, and coleoptiles after exposure to EMFs (50 Hz, 7 mT) and their controls. EMF exposure resulted in faster germination and the more rapid early growth of organs, especially in big seeds in dark conditions. The faster germination and seedling growth of small seeds in control conditions, and of big seeds after EMF exposure, corresponds largely to the decline in IAA and ABA levels. This study confirms that presowing treatment with an EMF is a promising tool for sustainable seed crop improvement, but detailed studies on the EMF mechanism of action, including phytohormones, are necessary to better control future crop yield, especially considering the factor of seed size.
The Effects of 3,5-Dimethylpyrazole on Soil Nitrification and Related Enzyme Activities in Brown Soil
Authors: Lu Yuanchuang , Li Dongxiao , Li Changqing , Sun Mengyu , Wu Zhijie , Sun Zhimei
Published: June 2022

Heterocyclic nitrogen compounds containing two adjacent nitrogen atoms generally have a significant effect on soil nitrification inhibition, and 3,5-dimethylpyrazole (DMP) is a typical representative of this structure. However, the inhibitory effect and the regulatory mechanism of DMP on soil N transformation are unclear. In this study, a microcosm with different concentrations of DMP was carried out in brown soil to detect the dynamic changes of soil NH4+–N, NO3–N and related soil enzyme activities. Results showed that DMP inhibited soil nitrification effectively and decreased soil nitrate reductase activity, while increasing nitrite reductase and dehydrogenase activities. The inhibition effects were dose dependent, and DMP at the rate of 0.025 g kg−1 dry soil showed the strongest inhibitory effect on N transformation in brown soil. The soil dehydrogenase activity was increased with an increasing DMP application rate. The changes in the soil’s chemical and biological properties caused by DMP application provided a new idea for systematically explaining how DMP participated in the soil N transformation process. This study further implied that DMP would play positive roles in alleviating environmental pressure by delaying nitrate-N formation and decreasing the activity of nitrate reductase.
Can Interpretable Reinforcement Learning Manage Prosperity Your Way?
Authors: Maree Charl , Omlin Christian W.
Published: June 2022

Personalisation of products and services is fast becoming the driver of success in banking and commerce. Machine learning holds the promise of gaining a deeper understanding of and tailoring to customers’ needs and preferences. Whereas traditional solutions to financial decision problems frequently rely on model assumptions, reinforcement learning is able to exploit large amounts of data to improve customer modelling and decision-making in complex financial environments with fewer assumptions. Model explainability and interpretability present challenges from a regulatory perspective which demands transparency for acceptance; they also offer the opportunity for improved insight into and understanding of customers. Post-hoc approaches are typically used for explaining pretrained reinforcement learning models. Based on our previous modeling of customer spending behaviour, we adapt our recent reinforcement learning algorithm that intrinsically characterizes desirable behaviours and we transition to the problem of prosperity management. We train inherently interpretable reinforcement learning agents to give investment advice that is aligned with prototype financial personality traits which are combined to make a final recommendation. We observe that the trained agents’ advice adheres to their intended characteristics, they learn the value of compound growth, and, without any explicit reference, the notion of risk as well as improved policy convergence.
Kinetic Model of Isothermal Bainitic Transformation of Low Carbon Steels under Ausforming Conditions
Authors: Kumnorkaew Theerawat , Lian Junhe , Uthaisangsuk Vitoon , Bleck Wolfgang
Published: June 2022

Carbide-free bainitic steels show attractive mechanical properties but are difficult to process because of the sluggish phase transformation kinetics. A macroscopic model based on the classical nucleation theory in conjunction with the modified Koistinen–Marburger relationship is proposed in this study to simulate the kinetics of incomplete bainitic and martensitic phase transformations with and without austenite deformation. A 0.26C-1Si-1.5Mn-1Cr-1Ni-0.003B-0.03Ti steel and a 0.18C-1Si-2.5Mn-0.2Cr-0.2Ni-0.02B-0.03Ti steel were investigated with different levels of ausforming. The concept of ausforming is expected to accelerate the onset of the bainitic transformation and to enhance the thermodynamic stability of austenite by increased dislocation density. The phase transformation kinetics of both steels is quantitatively analyzed in the study by dilatometry and X-ray diffraction so that the carbon concentration in the retained austenite and bainitic ferrite, as well as their volume fractions, is determined. A critical comparison of the numerical and experimental data demonstrates that the isothermal kinetics of bainite formation and the variation of driving energy can be satisfactorily described by the developed model. This model captures the incompleteness of the bainite phase transformation and the carbon enrichment in the austenite well. A fitting parameter can be used to elucidate the initial energy barrier caused by the ausforming. An increase in austenite stability can be described by the nucleation reaction and the thermodynamic energies associated with the change of dislocation density. The proposed model provides an in-depth understanding of the effect of ausforming on the transformation kinetics under different low-carbon steels and is a potential tool for the future design of heat treatment processes and alloys.
Effects of Pasteurella multocida on Histopathology, miRNA and mRNA Expression Dynamics in Lung of Goats
Authors: Zhang Wencan , Jiao Zizhuo , Huang Huixian , Wu Yanru , Wu Haotian , Liu Zhiyong , Zhang Zhenxing , An Qi , Cheng Yiwen , Chen Si , Man Churiga , Du Li , Wang Fengyang , Chen Qiaoling
Published: June 2022

Pasteurella multocida (Pm) infection causes severe respiratory disease in goats. We investigated the effects of the Pm infection intratracheally on the histopathology, miRNA and mRNA expression dynamics in the lung of goats infected for 1, 2, 5 and 7 days. Pm infection caused fever, which significantly (p < 0.05) increased the body temperature of the goats from day 1 to 5. Haemotoxylin–eosin staining of the infected lung tissue showed characteristics of suppurative pneumonia with inflammatory cells infiltration and the lung structure destruction. During the Pm infection of the goats, compared with the control group, there were 3080, 3508, 2716 and 2675 differentially expressed genes and 42, 69, 91 and 108 significantly expressed miRNAs (|log2Fold Change| > 1, p < 0.05) in the Pm_d1, Pm_d2, Pm_d5 and Pm_d7 groups, respectively. Five miRNAs and nine immune-related genes were selected for confirmation by reverse transcription–polymerase chain reaction. The results indicated that the expression patterns of the miRNAs and genes were consistent with those determined by next-generation sequencing. The differentially expressed genes were enriched in cytokine–cytokine receptor interaction, cell adhesion molecules, complement and coagulation cascades, tight junction and phagosome Kyoto Encyclopedia of Genes and Genomes pathways and cytokine production, leukocyte migration, myeloid leukocyte migration, cell periphery, plasma membrane, extracellular region part, extracellular region and other Gene Ontology terms. The differentially expressed genes were mapped to marker genes in human and mouse lung cells. The results showed the presence of some marker genes of the immune cells. Compared with the CK group, five miRNAs and 892 common genes were differentially expressed in the Pm_d1, Pm_d2, Pm_d5 and Pm_d7 groups. The target relationships between the common 5 miRNAs and 892 differentially expressed genes were explored and the miRNAs involved in the host immune reaction may act through the target genes. Our study characterized goats’ reaction in the lung from histopathological and molecular changes upon Pm infection, which will provide valuable information for understanding the responses in goats during Pm infection.
Genome-Wide Association Study of Feed Efficiency Related Traits in Ducks
Authors: Guo Qixin , Huang Lan , Jiang Yong , Wang Zhixiu , Bi Yulin , Chen Guohong , Bai Hao , Chang Guobin
Published: June 2022

Feed efficiency (FE) is the most important economic trait in the poultry and livestock industry. Thus, genetic improvement of FE may result in a considerable reduction of the cost and energy burdens. As genome-wide association studies (GWASs) can help identify candidate variants influencing FE, the present study aimed to analyze the phenotypic correlation and identify candidate variants of the seven FE traits in ducks. All traits were found to have significant positive correlations with varying degrees. In particular, residual feed intake presented correlation coefficients of 0.61, 0.54, and 0.13 with feed conversion ratio, and feed intake, respectively. Furthermore, data from seven FE-related GWAS revealed 4 (FCR), 3 (FI), 36 (RFI), 6 (BWG), 8 (BW21), and 10 (BW42) SNPs were significantly associated with body weight gain, feed intake, residual feed intake, feed conversion ratio, and weight at 21 and 42 days, respectively. Candidate SNPs of seven FE trait-related genes were involved in galactose metabolism, starch, propanoate metabolism, sucrose metabolism and etc. Taken together, these findings provide insight into the genetic mechanisms and genes involved in FE-related traits in ducks. However, further investigations are warranted to further validate these findings.
Developmental Alterations of Colonic microRNA Profiles Imply Potential Biological Functions in Kid Goats
Authors: Yan Qiongxian , Tian Lina , Chen Wenxun , Kang Jinhe , Tang Shaoxun , Tan Zhiliang
Published: June 2022

The colon is a crucial digestive organ of the hind gut in ruminants. The bacterial diversity and mucosal immune maturation in this region are related to age. However, whether the microRNA expression in the colon of goats is affected by age is still unclear. In the current study, we analyzed the transcriptomes of colon microRNAs during preweaning (Day 10 and Day 25) and postweaning (Day 31). A total of 1572 microRNAs were identified in the colon tissues. Of these, 39 differentially expressed microRNAs (DEmiRNAs) and 88 highly expressed microRNAs (HEmiRNAs) were screened. The target genes regulated by the DEmiRNAs and HEmiRNAs were commonly enriched in the MAPK signaling pathway, Wnt signaling pathway, Hippo signaling pathway, cell adhesion molecules, focal adhesion, and adherens junction. Remarkably, the targeted genes of the DEmiRNAs were highly enriched for the prevention of microbial invasion via the Erbb−MAPK network while the targeted genes of HEmiRNAs contributed to the permeable barrier maintenance and cell damage surveillance. Additionally, there were eight different expression profiles of 87 dynamic miRNAs, in which approximately half of them were affected by age. Taken together, our study reveals the different roles of DEmiRNAs, HEmiRNAs, and dynamic microRNAs in the development of the colon and gives new insights into the regulatory mechanism of colon development in goats.
Phytochemicals, Nutrition, Metabolism, Bioavailability, and Health Benefits in Lettuce—A Comprehensive Review
Authors: Shi Min , Gu Jingyu , Wu Hanjing , Rauf Abdur , Emran Talha Bin , Khan Zidan , Mitra Saikat , Aljohani Abdullah S. M. , Alhumaydhi Fahad A. , Al-Awthan Yahya S. , Bahattab Omar , Thiruvengadam Muthu , Suleria Hafiz A. R.
Published: June 2022

Lettuce is one of the most famous leafy vegetables worldwide with lots of applications from food to other specific uses. There are different types in the lettuce group for consumers to choose from. Additionally, lettuce is an excellent source of bioactive compounds such as polyphenols, carotenoids, and chlorophyll with related health benefits. At the same time, nutrient composition and antioxidant compounds are different between lettuce varieties, especially for green and red lettuce types. The benefit of lettuce consumption depends on its composition, particularly antioxidants, which can function as nutrients. The health benefits rely on their biochemical effect when reaching the bloodstream. Some components can be released from the food matrix and altered in the digestive system. Indeed, the bioaccessibility of lettuce is measuring the quantity of these compounds released from the food matrix during digestion, which is important for health-promoting features. Extraction of bioactive compounds is one of the new trends observed in lettuce and is necessarily used for several application fields. Therefore, this review aims to demonstrate the nutritional value of lettuce and its pharmacological properties. Due to their bioaccessibility and bioavailability, the consumer will be able to comprehensively understand choosing a healthier lettuce diet. The common utilization pattern of lettuce extracted nutrients will also be summarized for further direction.
Quantitative Determination of 5-Aminoisoquinoline, a PARP-1 Inhibitor by UPLC-MS/MS: In Silico ADME Profile and In Vitro Metabolic Stability Study
Authors: Iqbal Muzaffar , Ali Essam A. , Kalam Mohd Abul , Ahmad Sheikh F. , Al-Salahi Rashad
Published: June 2022

5-Aminoisoquinoline (5-AIQ) is a water-soluble, potent and selective Poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor, widely used as a biochemical and pharmacological tool to study the inhibitory effect of PARPs enzyme. In this study, a simple, selective and reliable ultra-performance liquid chromatography-tandem mass spectrometry assay has been developed for the quantitative analysis of 5-AIQ in plasma using pantoprazole as an internal standard (IS). Both 5-AIQ and IS were separated on an Acquity CSH18 (2.1 × 100 mm; 1.7 µm) column after chromatographic elution of mobile phase comprising of 10 mM ammonium acetate and acetonitrile (35:65; v/v) at a flow rate of 0.3 mL/min. Electrospray ionization in positive mode was used for sample ionization and precursor to product ion transitions of 145.0 > 91.0; 145.0 > 117.4 for 5-AIQ and 384.0 > 138.1 for IS were used for detection and quantification in multiple reaction monitoring mode. The assay was linear in the concentration range of 1.0 to 666 ng/mL with correlation coefficient of ≥0.995. The precision and bias were within the acceptable limits of ≤12.68% and −8.6 to 5.9%, respectively, with mean recovery of 79.1% from plasma and negligible matrix effects (92.4%). In silico ADME prediction, 5-AIQ showed to be very soluble in water and high gastrointestinal absorption along with blood–brain barrier (BBB) permeability. The validated assay was successfully applied in a metabolic stability study, and 5-AIQ was moderately metabolized by human liver microsomes with an in vitro half-life of 14.5 min and intrinsic clearance of 47.6 µL/min/mg. The validated method can be utilized for future pharmacokinetic and bio-distribution studies.