bluuebunny/crossref_metadata_2025 huggingface dataset:
Story character, news source or vox pop? Representations and roles of citizen perspectives in crime news narratives
Authors: van Krieken Kobie
Published: March 2021

This study analyzes citizen representations in a corpus of 300 Dutch newspaper narratives published between 1860 and 2009. Results show that citizen perspectives are more frequently represented than authority perspectives, although the perspectives of authorities have become somewhat more frequent over time. In-depth analyses of the citizen perspectives show that citizens may fulfil multiple roles in the crime narratives, leading up to a functional typology of citizens as (1) story characters experiencing the news events, (2) news sources providing inside information about the events, and (3) vox pops expressing opinions and evaluations of the events. The variety of citizen perspectives included in crime news narratives and the multitude of roles they fulfill may help audience members to become informed as well as engaged and to explore their personal emotions, which may ultimately reinforce moral, cultural and societal values.
Divorce, kinship, and errant wives: Islamic feminism in India, and the everyday life of divorce and maintenance
Authors: Dutta Sagnik
Published: March 2021

This article is an ethnographic exploration of a women’s sharia court in Mumbai, a part of a network of such courts run by women qazi (Islamic judges) established across India by members of an Islamic feminist movement called the Bharatiya Muslim Mahila Andolan (Indian Muslim Women’s Movement). Building upon observations of adjudication, counselling, and mediation offered in cases of divorce and maintenance by the woman qazi (judge), and the claims made by women litigants on the court, this article explores the imaginaries of the heterosexual family and gendered kinship roles that constitute the everyday social life of Islamic feminism. I show how the heterosexual family is conceptualised as a fragile and violent institution, and divorce is considered an escape route from the same. I also trace how gendered kinship roles in the heterosexual conjugal family are overturned as men fail in their conventional roles as providers and women become breadwinners in the family. In tracing the range of negotiations around the gendered family, I argue that the social life of Islamic feminism eludes the discourses and categories of statist legal reform. I contribute to existing scholarship on Islamic feminism by exploring the tension between the institutionalist and everyday aspects of Islamic feminist movements, and by exploring the range of kinship negotiations around the gendered family that take place in the shadow of the rhetoric of ‘law reform’ for Muslim communities in India.
Applying feminist principles to social work teaching: Pandemic times and beyond
Authors: Hutchison Jessica
Published: March 2021

It took a global pandemic for me to recognize how my social work teaching was an act of feminist praxis. I have long identified as a feminist and regularly engage efforts to advance equity for women, primarily centered on the abolition of prisons which disproportionately incarcerate Indigenous and Black women in Canada. Surprisingly, I have never considered how my feminism shows up in my teaching. The following reflexive essay explores the ways in which the feminist principles of centring emotions, rejecting patriarchal hierarchy, and challenging white feminism were embedded into the development and delivery of a graduate level social work research course that was rapidly adapted to being taught online during a global public health crisis. It ends with a call to action for social work educators to incorporate feminist principles into their pedagogies, not only in times of crisis, but as standard practice.
Narratives, masks and COVID-19: A qualitative reflection
Authors: Wong Jade , Claypool Emily
Published: March 2021

Tracing explanatory narratives of mask-wearing throughout COVID-19, we argue that multiple narratives contribute to the global experience of COVID-19, making it as much a social and political object as it is a scientific one. This assumption drives our commitment to take seriously alternative narratives that do not conform to dominant ones in order to examine how structures of power might privilege particular types of ‘truths’ and with what consequences. We see this reflective piece as a re-articulation of social work’s historic call to interrogate dominant ways of knowing, particularly the ways in which science obscures its own power and politics and sidelines other narratives in the process.
An ethic of care? Academic administration and pandemic policy
Authors: Bryson Stephanie A
Published: March 2021

This reflexive essay examines the adoption of an intentional ‘ethic of care’ by social work administrators in a large social work school located in the Pacific Northwest. An ethic of care foregrounds networks of human interdependence that collapse the public/private divide. Moreover, rooted in the political theory of recognition, a care ethic responds to crisis by attending to individuals’ uniqueness and ‘whole particularity.’ Foremost, it rejects indifference. Through the personal recollections of one academic administrator, the impact of rejecting indifference in spring term 2020 is described. The essay concludes by linking the rejection of indifference to the national political landscape.
A sanctuary: Mourning the loss of the classroom during COVID
Authors: Mitchell Dove Lakindra
Published: March 2021

This reflexive essay explores the challenges and successes that I encountered as a professor during the transition from face-to-face teaching to remote teaching due to COVID. The essay outlines my thought processes and emotional responses to how unfamiliarity with teaching remotely, coupled with the stress of a pandemic, significantly impacted my teaching style. It also highlights my observations of students’ experiences from their shared discussions and interactions with other students as they navigated the initial onset of challenges during the spring term of 2020. The essay discusses the importance of adaptability during a time when we were collectively experiencing trauma, and embracing teaching practices that were supportive of students' educational and emotional needs. It highlights how navigating these challenges were beneficial for both myself and students, as we collectively addressed the complexities of changes to our personal and academic lives. This essay includes lessons learned as a professor and how I was able to maintain the integrity of the classroom by holding space for the experiences of students during a pandemic.
Experiences of the Covid-19 pandemic: From the perspective of an MSW student
Authors: Hugo Tina
Published: March 2021

This reflexive essay offers an uncensored narrative and delves deep into the life of one MSW student during the Covid-19 pandemic. Five themes were uncovered through intense reflexive based practices and these included: parenting and food insecurity, silencing of the voice, grieving the practicum placement, the white gaze and a reduced empathetic capacity. Ultimately, meaning making is achieved through unsettling the concept of the self, identifying and exposing vulnerability and deflowering the power dynamics operating within Canada.
Childhood Maltreatment and Relationship Quality: A Review of Type of Abuse and Mediating and Protective Factors
Authors: Zamir Osnat
Published: March 2021

Childhood maltreatment (CM) has long been recognized as a risk factor for good intimate relationships. Research on the effects of CM on relationship functioning has focused on sexual abuse in girls. However, CM also includes emotional and physical abuse and neglect and is also common in boys. Moreover, prior research has mostly focused on individuals in isolation, ignoring that marriage is a system in which two partners mutually influence each other. Questions also remain about mediating and protective factors for healthy relationships in the context of CM. This article reviews the literature on the link between different forms of CM and one’s own and one’s partner relationship quality. It reviews 43 empirical studies that assessed associations between CM in any form and relationship quality. Also, mediating and protective factors and major methodological topics are examined. The review indicated that CM (neglect, sexual, emotional, or physical abuse) is associated with lower relationship quality in men and women. Psychological distress, cognitive and behavioral problems, insecure attachment, and self-dysregulation were identified as mediating factors. Protective processes involve good coping strategies, emotion regulation, parental support, and early secure attachment, but not partner characteristics. The results regarding gender are inconclusive. It is crucial to broaden the research on the dyadic effects of CM of various forms on relationship quality and study mediating and protective factors. More studies on neglect and diverse populations are needed, as well as prospective studies. This will enable the development of prevention programs for couples with a partner exposed to CM.
Remodeling of Abdominal Aortic Angulation and Curvature After Endovascular Aneurysm Repair in Patients With vs Without Late Type Ia Endoleak or Endograft Migration
Authors: Schuurmann Richte C. L. , Kropman Rogier , Ouriel Kenneth , Jordan William D. , Muhs Bart E. , ‘t Mannetje Yannick , Reijnen Michel M. P. J. , Fioole Bram , Ünlü Çağdaş , Brummel Peter , de Vries Jean-Paul P. M.
Published: March 2021

Purpose:

To investigate aortic remodeling of the supra- and infrarenal aorta from preoperative to 1 month and midterm follow-up after endovascular aneurysm repair (EVAR) by analyzing changes in angulation and curvature in patients with vs without late type Ia endoleak or device migration.

Materials and Methods:

From a multicenter database, 35 patients (mean age 76±5 years; 31 men) were identified with late (>1 year) type Ia endoleak or endograft migration (≥10 mm) and defined as the complication group. The control group consisted of 53 patients (mean age 75±7 years; 48 men) with >1-year computed tomography angiography (CTA) follow-up and no evidence of endoleaks. Suprarenal and infrarenal angles were measured on centerline reconstructions of the preoperative, 1-month, and midterm CTA scans. The value and location relative to baseline of maximum suprarenal and infrarenal curvature were determined semiautomatically using dedicated software. Changes were determined at 1 month compared with the preoperative CTA and at midterm compared with 1 month.

Results:

Preoperative suprarenal angulation was significantly greater in the complication group compared to the controls (34°±18° vs 24°±17°, p=0.008). It decreased significantly at 1 month in the complication group (29°±16°, p=0.011) and at midterm follow-up in the controls (20°±19°, p<0.001). Preoperative infrarenal angulation was not significantly different (57°±15° vs 49°±24°, p=0.114). This measurement increased significantly through midterm follow-up in the complication group (63°±23°, p<0.001) but remained stable in the controls (46°±22°). Preoperative suprarenal curvature was not significantly different (38±22 m−1 vs 29±25 m−1, p=0.115). This variable increased significantly through midterm follow-up in the complication group (44±22 m−1) but remained constant in the controls (28±22 m−1). Preoperative infrarenal curvature was significantly greater in the complication group (77±29 m−1 vs 65±28 m−1, p=0.047) and decreased significantly in both groups during midterm follow-up (50±17 m−1 vs 41±19 m−1 p=0.033). The location of the maximum curvature with regard to baseline shifted significantly distally in the complication group (54±43 to 72±41 mm, p<0.001), while it remained stable in the controls (46±33 to 48±31 mm).

Conclusion:

At midterm follow-up, significant differences in supra- and infrarenal angulation and curvature were observed between patients with vs without type Ia endoleak or migration. The location of the maximum curvature shifted distally in patients with complications. The aortic morphology is more stable during midterm follow-up in the patients without endoleaks.
Anti-tumor necrosis factor-induced lupus in patients with inflammatory bowel disease: a hospital-based cohort study from Korea
Authors: Choi Su Jin , Ahn Soo Min , Oh Ji Seon , Hong Seokchan , Lee Chang-Keun , Yoo Bin , Ye Byong Duk , Yang Suk-Kyun , Park Sang Hyoung , Kim Yong-Gil
Published: March 2021

Background:

Anti-tumor necrosis factor (TNF) agents are increasingly used for rheumatic diseases and inflammatory bowel disease (IBD), but are associated with the development of anti-TNF-induced lupus (ATIL). Nonetheless, few ATIL studies on non-Caucasian IBD patients exist. Here, we investigated the incidence, clinical features, and risk factors of ATIL in Korea.

Methods:

We retrospectively reviewed the medical records of IBD patients undergoing anti-TNF therapy at our tertiary IBD center between 2008 and 2020. ATIL was diagnosed as a temporal association between symptoms and anti-TNF agents, and the presence of at least one serologic and non-serologic American College of Rheumatology criterion. The risk factors for ATIL occurrence were assessed using multivariate Cox regression analysis.

Results:

Of 1362 IBD patients treated with anti-TNF agents, 50 (3.7%) ATIL cases were suspected, of which 14 (1.0%) received a definitive diagnosis. Arthritis and mucocutaneous symptoms were observed in 13 and 4 patients, respectively. All ATIL cases were positive for anti-nuclear and anti-dsDNA antibodies. Four patients (30.8%) improved while continuing anti-TNF therapy. At the final follow up, the ATIL group ( n = 14) had a lower IBD remission rate (30.8% versus 68.8%, p = 0.019) than the non-ATIL group ( n = 36). Ulcerative colitis and longer disease duration were associated with ATIL occurrence, with hazard ratios of 7.017 ( p = 0.005) and 1.118 ( p = 0.002), respectively.

Conclusion:

Although rare, ATIL is associated with poor treatment response to IBD in Korean patients. ATIL should be considered if arthritis and mucocutaneous symptoms develop during anti-TNF therapy for IBD.
Teach Me What I Do Not See: Lessons for the Church From a Global Pandemic
Authors: Porter Steven L. , Kapic Kelly M. , Barton Ruth Haley , Peace Richard , Chandler Diane J. , Tan Siang Yang , Wilhoit James C.
Published: March 2021

In an attempt to learn from COVID-19, this essay features six responses to the question: what did COVID-19 teach us, expose in us, or purge out of us when it comes to spiritual formation in Christ? Each response was written independently of the others by one of the coauthors. Diane J. Chandler focuses in on how COVID-19 exposed grievous inequities for ethnic groups in the American church and broader society. Kelly M. Kapic reminds us of the goodness of human finitude and how COVID restrictions have forced many of us to embrace our limitations. Siang-Yang Tan reflects on eight lessons he has learned during this pandemic year in his role shepherding a local church. James C. Wilhoit calls us to consider the structures that are needed for local church leadership to make wise and godly decisions in times of crisis. Richard Peace draws our attention to what might be learned from the forced monasticism brought about by COVID-19 quarantines. Finally, Ruth Haley Barton pauses to consider the interdependence of human life that has been dramatically illustrated by this pandemic. While these six responses certainly do not exhaust all there is for the church to learn from COVID, we present them in the spirit of “O Lord, teach us what we do not see” and hope they will inspire your own reflections.
Imaging findings of cutaneous angiosarcoma of the scalp: Comparison with cutaneous squamous cell carcinoma
Authors: Kawaguchi Masaya , Kato Hiroki , Suzui Natsuko , Miyazaki Tatsuhiko , Tomita Hiroyuki , Hara Akira , Matsuyama Kanako , Seishima Mariko , Matsuo Masayuki
Published: March 2021

Purpose

This study aimed to evaluate imaging findings of cutaneous angiosarcoma (cAS) of the scalp compared with those of cutaneous squamous cell carcinoma (cSCC).

Methods

This study included 15 patients with primary cAS and 10 with primary cSCC of the scalp. Seven patients with cAS and eight with cSCC underwent magnetic resonance imaging, and 11 patients with cAS and eight with cSCC underwent 18F-fluorodeoxyglucose–positron emission tomography/computed tomography imaging. Imaging findings for both pathologies were retrospectively reviewed and compared.

Results

All 15 cAS cases were elevated lesions with an obtuse angle, invading the subcutaneous fat tissue. Multiple lesions were observed in only five cAS cases (33%) and no cSCC cases. Maximum diameter-to-height ratio was significantly higher in cAS than in cSCC (3.3 ± 1.0 versus 2.3 ± 0.6; p < 0.01). On T2-weighted images, intratumoral hypointensity (86% versus 13%; p < 0.01) and mixed hyper- and hypointensity (71% versus 0%; p < 0.01) were observed more frequently in cAS than in cSCC. No significant differences were observed between cAS and cSCC regarding flow void (29% versus 25%; p = 0.656). Maximum standardized uptake values were marginally significantly lower in cAS than in cSCC (5.6 ± 3.1 versus 10.5 ± 6.6; p = 0.078).

Conclusions

Cases of cAS of the scalp always exhibited flat elevated lesions with invasion of the subcutaneous fat tissue. Compared with cSCC, intratumoral hypointensity and mixed hyper- and hypointensity on T2-weighted images were more frequent in cAS. These findings will help with the differential diagnosis of cAS.
Physiological pseudo-thickened cauda equina associated with dural sac dilatation on magnetic resonance imaging
Authors: Matsushima Satoshi , Shimizu Tetsuya , Baba Akira , Ojiri Hiroya
Published: March 2021

Objectives

In daily clinical practice, the assessment of the thickness of the cauda equina on lumbar spine magnetic resonance imaging is an important parameter. However, its relevance to the size of the dural sac in non-pathological conditions is unknown. To examine the relationship between the size of the dural sac and the apparent thickness of the cauda equina nerve root using lumbar spine magnetic resonance imaging in non-pathological conditions.

Methods

We retrospectively measured the dural sac diameter and vertebral body diameter, counted the apparent number, and calculated total cross-sectional area of the cauda equina, dural sac ratio and the area of one apparent nerve root of cauda equina in 100 cases. Spearman's rank correlation coefficient ( ρ) was used.

Results

Dural sac ratio and diameter were positively correlated with the area of one apparent nerve root ( ρ=0.77, P<0.001; ρ=0.74, P<0.001; respectively) and negatively correlated with the apparent number of cauda equina in a single cross-section ( ρ=–0.63, P<0.001; ρ=–0.52, P<0.001; respectively).

Conclusions

A larger dural sac ratio and diameter was associated with an apparently thicker cauda equina and lower visible number. In a larger dural sac, the physiologically clumped and apparently thicker cauda equina should not be misdiagnosed as pathological.
Rapid resolution of severe subcutaneous emphysema causing respiratory failure with subcutaneous drain
Authors: Mustafa Ala , Heleno Caio , Summerfield Douglas T
Published: March 2021

This case reports on a critically ill patient (Male, 74) with severe subcutaneous emphysema which progressed to causing respiratory distress. We document both the severity of the condition we observed and then present a novel intervention. In this case, we decompressed the patient at the intensive care unit-bedside and resolved the condition. While subcutaneous emphysema is relatively common, the severity of the condition we observed, and the lack of definitive treatment guidance have prompted us to present this case as a plausible treatment guide.
Perception of nurse managers’ care coordination practices among nurses at the unit level
Authors: Ofei Adelaide M.A. , Paarima Yennuten
Published: March 2021

Introduction

Nursing practice demands coordination of activities within and across units to enable quality delivery of healthcare services. Nurse managers are best positioned to ensure effective care coordination at the operational level in the hospitals. The purpose of this study was to examine the care coordination practices of nurse managers at the unit level.

Methods

A quantitative exploratory descriptive approach using a cross-sectional survey design was used to collect data from 522 nurses in 19 hospitals in the Greater Accra region of Ghana. Descriptive and regression analyses were performed to describe the sample and to predict the behaviour of nurse managers. The systems model was used as a conceptual framework for the survey. Data collection was from October 2015 to March 2016.

Results

The response rate for collection of data was 95.7%. Nurse managers exhibited an acceptable level of care coordination practices. Nurse managers’ characteristics together predicted the care coordination practices at the unit (R2=0.111, p < 0.001). The unit, unit workload, experience as a nurse manager, and work duration with nurses were the significant predictors in the regression model.

Discussion

Care coordination is needed at the unit level to prevent conflict, overlapping, and constant interdepartmental friction which enables nurses to take a broad overview of coordinated care instead of myopic observation and reflection in the unit. Nurse managers are best positioned to coordinate care due to their vast professional knowledge and experience. Effective communication, good interpersonal relationship, and good listening skills are essential coordination practices critical to the efficiency of the unit.
Return to Play After Revision Anterior Shoulder Stabilization: A Systematic Review
Authors: Lau Brian C. , Pineda Lorena Bejarano , Johnston Tyler R. , Gregory Bonnie P. , Wu Mark , Fletcher Amanda N. , Ledbetter Leila , Riboh Jonathan C.
Published: March 2021

Background:

Revision shoulder stabilizations are becoming increasingly common. Returning to play after revision shoulder stabilizations is important to patients.

Purpose:

To evaluate the return-to-play rate after revision anterior shoulder stabilization using arthroscopic, open, coracoid transfer, or free bone block procedures.

Study Design:

Systematic review; Level of evidence, 4.

Methods:

All English-language studies published between 2000 and 2020 that reported on return to play after revision anterior shoulder stabilization were reviewed. Clinical outcomes that were evaluated included rate of overall return to play, level of return to play, and time to return to play. Study quality was evaluated using the Downs and Black quality assessment score.

Results:

Eighteen studies (1 level 2; 17 level 4; mean Downs and Black score, 10.1/31) on revision anterior shoulder stabilization reported on return to play and met inclusion criteria (7 arthroscopic, 5 open, 3 Latarjet, and 3 bony augmentation), with a total of 564 revision cases (mean age, 27.9 years; 84.1% male). The weighted mean length of follow-up was 52.5 months. The overall weighted rate of return to play was 80.1%. The weighted mean rate of return to play was 84.0% (n = 153) after arthroscopic revision, 91.5% (n = 153) after open revision, 88.1% (n = 149) after Latarjet, and 73.8% (n = 65) after bone augmentation. The weighted mean rate of return to same level of play was 69.7% for arthroscopic revision, 70.0% for open revision, 67.1% for Latarjet revision, and 61.8% after bone block revision. There were 5 studies that reported on time to return to play, with a weighted mean of 7.75 months (4 arthroscopic) and 5.2 months (1 Latarjet). The weighted mean rates of complication (for studies that provided it) were 3.3% after arthroscopic revision (n = 174), 3.5% after open revision (n = 110), 9.3% after Latarjet revision (n = 108), and 45.8% after bone block revision (n = 72).

Conclusion:

Revision using open stabilization demonstrated the highest return-to-play rate. Revision using Latarjet had the quickest time to return to play but had higher complication rates. When evaluated for return to same level of play, arthroscopic, open, and Latarjet had similar rates, and bone block had lower rates. The choice of an optimal revision shoulder stabilization technique, however, depends on patient goals. Higher-quality studies are needed to compare treatments regarding return to play after revision shoulder stabilization.
Use of Health Information Varies by Region Among Older Adults in the U.S.
Authors: Mathis Arlesia , Rooks Ronica N. , Wiltshire Jacqueline
Published: March 2021

Objective: To examine geographic variations in health information use among older adults in the United States. Methods: We compared 15,531 adults (age 45 and older) across four U.S. regions. Descriptive analyses were conducted to assess health information seeking and use by year. The relationship between health information seeking or use and regional changes were assessed using binomial logistic regression. Binomial models were adjusted by socio-demographics, chronic conditions, and health information sources. Magnitude and direction of relationships were assessed using adjusted odds ratios (aORs), 95% confidence intervals (CIs), and p-values. Results: Only the Northeast region showed increases in health information seeking (3.8%) and use (4.5%) among older adults. However adjusted models showed those living in the Northeast were 28% less likely to use health information to maintain their health and 32% less likely to use health information to treat illness. Conclusion: As a result of the current pandemic, older adults are facing a growing burden from health care expenses. Inability to gather and use health information for personal safety or self care can potentially increase inequalities in health, especially for older adults without personal health care providers.
Head and Neck Paragangliomas: Patterns of Otolaryngology Referrals for Genetic Testing Over 2 Decades
Authors: Smith Joshua D. , Bellile Emily L. , Else Tobias , Basura Gregory
Published: March 2021

Objective

A large proportion of head and neck paragangliomas (HNPGLs) arise in patients with a genetic predisposition due to pathogenic variants in succinate dehydrogenase (SDHx) genes. Contemporary practice guidelines recommend consideration of referral for genetic testing for all patients with HNPGLs. We sought to assess adherence to these recommendations, factors associated with referral, and temporal trends in referral patterns by otolaryngologists over the past 2 decades.

Study Design

Retrospective cohort study.

Setting

Single tertiary care center.

Methods

All patients with newly diagnosed HNPGLs treated at a single academic center between 2000 and 2019 were included. Bivariable association of specific features of referral for genetic testing by treating surgeons were tested with χ2and Wilcoxon rank‐sum tests. Logistic regression was used to assess temporal trends in referral patterns overall and for specific clinical subgroups over time.

Results

Of 221 patients included, only 77 (34.8%) were referred for genetic testing. Factors associated with referral included young age, family history of paraganglioma, more recent year of diagnosis (ie, closer to study end date), tumor subsite (allP<. 0001), and treatment by an otolaryngologist (vs vascular surgeon or neurosurgeon,P=. 009). Overall, referral rates increased over time (P=. 0002), but even in the most recent 5 years, only 51% of newly diagnosed patients were referred.

Conclusion

Our analysis suggests that referral rates for genetic testing in patients with HNPGLs are growing yet are still largely based on young age, family history, and tumor subsite.
Relationship of donor age and relationship to outcomes of haploidentical transplantation with posttransplant cyclophosphamide
Authors: DeZern Amy E. , Franklin Clio , Tsai Hua-Ling , Imus Phil Hollingsworth , Cooke Kenneth R. , Varadhan Ravi , Jones Richard J.
Published: March 2021

Allogeneic blood or marrow transplantation (BMT) physicians seek to optimize all possible variables to improve outcomes. Selectable factors include conditioning, graft-versus-host disease (GVHD) prophylaxis, graft source, and donor. Many patients, especially those with eligible haploidentical (haplo) donors, will have multiple donor options. We seek to identify factors to optimize the choice of haplo donors when using posttransplantation cyclophosphamide (PTCy) GVHD prophylaxis. We evaluated the effect of modifiable donor characteristics (donor age and relationship) on outcomes following haplo BMT with a uniform nonmyeloablative conditioning and PTCy. From 2002 to 2017, 889 consecutive adult patients underwent nonmyeloablative haplo BMT with PTCy. Median follow-up among survivors was 2.5 years after BMT. Median recipient age was 59 (range: 18 to 76) years and median donor age was 40 (range: 13 to 79) years. Multivariable analyses demonstrated that increasing donor age by decade was associated with poorer overall survival (hazard ratio [HR], 1.13 [1.05, 1.22; P = .0015]), worse progression-free survival (HR, 1.09 [1.02, 1.16; P = .015]), and a higher risk for grade 2 to 4 and grade 3 to 4 GVHD (1.3 [1.06, 1.61; P = .013]), but not for chronic GVHD (HR, 1.06 [0.94, 1.2]; P = .37). These less-favorable results with older donors were attributable to worse nonrelapse mortality (HR, 1.19 [1.05, 1.34]; P = .006), not relapse. Parents were associated with inferior outcomes compared with sibling donors, whereas no significant differences were observed between parental donors. These data suggest that the youngest, adult-sized donors should be preferred when multiple haplo donors are available.
Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese
Authors: Wang Weiqi , Jiang Haiyang , Zhang Ziwei , Duan Wei , Han Tianshu , Sun Changhao
Published: March 2021

Background and objectives

Previous studies have found the important gene-diet interactions on type 2 diabetes (T2D) incident but have not followed branched-chain amino acids (BCAAs), even though they have shown heterogeneous effectiveness in diabetes-related factors. So in this study, we aim to investigate whether dietary BCAAs interact with the genetic predisposition in relation to T2D risk and fasting glucose in Chinese adults.

Methods

In a case-control study nested in the Harbin Cohort Study on Diet, Nutrition and Chronic Non-Communicable Diseases, we obtained data for 434 incident T2D cases and 434 controls matched by age and sex. An unweighted genetic risk score (GRS) was calculated for 25 T2D-related single nucleotide polymorphisms by summation of the number of risk alleles for T2D. Multivariate logistic regression models and general linear regression models were used to assess the interaction between dietary BCAAs and GRS on T2D risk and fasting glucose.

Results

Significant interactions were found between GRS and dietary BCAAs on T2D risk and fasting glucose (p for interaction = 0.001 and 0.004, respectively). Comparing with low GRS, the odds ratio of T2D in high GRS were 2.98 (95% CI 1.54–5.76) among those with the highest tertile of total BCAA intake but were non-significant among those with the lowest intake, corresponding to 0.39 (0.12) mmol/L versus − 0.07 (0.10) mmol/L fasting glucose elevation per tertile. Viewed differently, comparing extreme tertiles of dietary BCAAs, the odds ratio (95% CIs) of T2D risk were 0.46 (0.22–0.95), 2.22 (1.15–4.31), and 2.90 (1.54–5.47) (fasting glucose elevation per tertile: − 0.23 (0.10), 0.18 (0.10), and 0.26 (0.13) mmol/L) among participants with low, intermediate, and high genetic risk, respectively.

Conclusions

This study indicated that dietary BCAAs could amplify the genetic association with T2D risk and fasting glucose. Moreover, higher BCAA intake showed positive association with T2D when genetic predisposition was also high but changed to negative when genetic predisposition was low.
Long-term outcomes after penile prosthesis placement for the Management of Erectile Dysfunction: a single-Centre experience
Authors: Frydman Valentine , Pinar Ugo , Abdessater Maher , Akakpo William , Grande Pietro , Audouin Marie , Mozer Pierre , Chartier-Kastler Emmanuel , Seisen Thomas , Roupret Morgan
Published: March 2021

Background

Penile prothesis (PP) is the gold-standard treatment of drug-refractory erectile dysfunction (ED). While postoperative outcomes have been widely described in the literature, there are few data about patient satisfaction and intraoperative events. We aimed to assess long-term patient satisfaction and perioperative outcomes after PP implantation in a single-centre cohort of unselected patients using validated scales.

Results

A total of 130 patients received a PP (median age: 62.5 years [IQR: 58–69]; median International Index of Erectile Function (IEEF-5) score: 6 [IQR: 5–7]). Median follow-up was 6.3 years [IQR: 4–9.4]. Thirty-two (24.6%) patients underwent surgical revision, of which 20 were PP removals (15.4%). Global PP survival rate was 84.6% and previous PP placement was a risk factor for PP removal (p = 0.02). There were six (4.6%) non-life-threatening intraoperative events including two which resulted in non-placement of a PP (1.5%). EAUiaic grade was 0 for 124 procedures (95.4%), 1 for four procedures (3.1%) and 2 for two procedures (1.5%). Of patients who still had their PP at the end of the study, 91 (80.5%) expressed satisfaction.

Conclusions

PP implantation is a last-resort treatment for ED with a satisfactory outcome. PPs are well accepted by patients.
Oral microbiota and Helicobacter pylori in gastric carcinogenesis: what do we know and where next?
Authors: Bakhti Seyedeh Zahra , Latifi-Navid Saeid
Published: March 2021

Gastric cancer (GC) is one of the most common malignancies causing death worldwide, and Helicobacter pylori is a powerful inducer of precancerous lesions and GC. The oral microbiota is a complex ecosystem and is responsible for maintaining homeostasis, modulating the immune system, and resisting pathogens. It has been proposed that the gastric microbiota of oral origin is involved in the development and progression of GC. Nevertheless, the causal relationship between oral microbiota and GC and the role of H. pylori in this relationship is still controversial. This study was set to review the investigations done on oral microbiota and analyze various lines of evidence regarding the role of oral microbiota in GC, to date. Also, we discussed the interaction and relationship between H. pylori and oral microbiota in GC and the current understanding with regard to the underlying mechanisms of oral microbiota in carcinogenesis. More importantly, detecting the patterns of interaction between the oral cavity microbiota and H. pylori may render new clues for the diagnosis or screening of cancer. Integration of oral microbiota and H. pylori might manifest a potential method for the assessment of GC risk. Hence it needs to be specified the patterns of bacterial transmission from the oral cavity to the stomach and their interaction. Further evidence on the mechanisms underlying the oral microbiota communities and how they trigger GC may contribute to the identification of new prevention methods for GC. We may then modulate the oral microbiota by intervening with oral-gastric bacterial transmission or controlling certain bacteria in the oral cavity.
Interactional mechanisms of Paenibacillus polymyxa SC2 and pepper (Capsicum annuum L.) suggested by transcriptomics
Authors: Liu Hu , Li Yufei , Ge Ke , Du Binghai , Liu Kai , Wang Chengqiang , Ding Yanqin
Published: March 2021

Background

Paenibacillus polymyxaSC2, a bacterium isolated from the rhizosphere soil of pepper (Capsicum annuumL.), promotes growth and biocontrol of pepper. However, the mechanisms of interaction betweenP. polymyxaSC2 and pepper have not yet been elucidated. This study aimed to investigate the interactional relationship ofP. polymyxaSC2 and pepper using transcriptomics.

Results

P. polymyxaSC2 promotes growth of pepper stems and leaves in pot experiments in the greenhouse. Under interaction conditions, peppers stimulate the expression of genes related to quorum sensing, chemotaxis, and biofilm formation inP. polymyxaSC2. Peppers induced the expression of polymyxin and fusaricidin biosynthesis genes inP. polymyxaSC2, and these genes were up-regulated 2.93- to 6.13-fold and 2.77- to 7.88-fold, respectively. Under the stimulation of medium which has been used to culture pepper, the bacteriostatic diameter ofP. polymyxaSC2 againstXanthomonas citriincreased significantly. Concurrently, under the stimulation ofP. polymyxaSC2, expression of transcription factor genesWRKY2andWRKY40in pepper was up-regulated 1.17-fold and 3.5-fold, respectively.

Conclusions

Through the interaction with pepper, the ability ofP. polymyxaSC2 to inhibit pathogens was enhanced.P. polymyxaSC2 also induces systemic resistance in pepper by stimulating expression of corresponding transcription regulators. Furthermore, pepper has effects on chemotaxis and biofilm formation ofP. polymyxaSC2. This study provides a basis for studying interactional mechanisms ofP. polymyxaSC2 and pepper.
Surgery for primary tumor benefits survival for breast cancer patients with bone metastases: a large cohort retrospective study
Authors: Huang Zhangheng , Zhou Xin , Tong Yuexin , Zhu Lujian , Zhao Ruhan , Huang Xiaohui
Published: March 2021

Background

The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast cancer patients with BM and to develop prognostic nomograms to predict the overall survival (OS) of breast cancer patients with BM.

Methods

A total of 3956 breast cancer patients with BM from the Surveillance, Epidemiology, and End Results database between 2010 and 2016 were included. Propensity score matching (PSM) was used to eliminate the bias between the surgery and non-surgery groups. The Kaplan-Meier analysis and the log-rank test were performed to compare the OS between two groups. Cox proportional risk regression models were used to identify independent prognostic factors. Two nomograms were constructed for predicting the OS of patients in the surgery and non-surgery groups, respectively. In addition, calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA) were used to evaluate the performance of nomograms.

Result

The survival analysis showed that the surgery of the primary tumor significantly improved the OS for breast cancer patients with BM. Based on independent prognostic factors, separate nomograms were constructed for the surgery and non-surgery groups. The calibration and ROC curves of these nomograms indicated that both two models have high predictive accuracy, with the area under the curve values ≥0.700 on both the training and validation cohorts. Moreover, DCA showed that nomograms have strong clinical utility. Based on the results of the X-tile analysis, all patients were classified in the low-risk-of-death subgroup had a better prognosis.

Conclusion

The surgery of the primary tumor may provide survival benefits for breast cancer patients with BM. Furthermore, these prognostic nomograms we constructed may be used as a tool to accurately assess the long-term prognosis of patients and help clinicians to develop individualized treatment strategies.
Prevalence and determinants of chewing khat among women in Ethiopia: data from Ethiopian demographic and health survey 2016
Authors: Yitayih Yimenu , van Os Jim
Published: March 2021

Background

In Ethiopia and other countries in eastern Africa, khat abuse is an increasing public health problem. Levels of use appear to be increasing in women, who are more vulnerable to khat-related problems. However, population-based data are lacking as studies have been small and related to specific settings. This study aimed to contribute to current knowledge on the prevalence of chewing khat and associated factors among women in Ethiopia, using data from the 2016 Ethiopian national demographic and health survey.

Methods

The 2016 EDHS used a two-stage stratified sampling design to select households. A total of 645 enumeration areas (202 urban and 443 rural) were selected, based on the 2007 Ethiopia Population and Housing Census. In these, 18,008 households were considered, from which 15,683 women were included from individual households. The women were interviewed by trained lay interviewers. Data were tabulated and logistic regression was used to examine mutually adjusted associations, expressed as adjusted odds ratios.

Results

The lifetime prevalence of chewing khat among women was 9.9%. Current khat use was 8.4%, with a mean of 14.2 days of use in the last month. Khat use increased with increasing age, remaining constant after age 35 years, having one child, lower educational level, being Muslim by religion and not pertaining to the lowest wealth index category. Not being in a marital relationship with the most recent sex partner and Protestant religion were protective factors.

Conclusion

Lifetime prevalence of chewing khat among women in Ethiopia is substantial and associated with specific sociodemographic risks. These can be used in targeted public health efforts to control the use of khat and reduce the associated health and economic burden.
Measles outbreak in complex emergency: estimating vaccine effectiveness and evaluation of the vaccination campaign in Borno State, Nigeria, 2019
Authors: Jean Baptiste Anne Eudes , Wagai John , Luce Richard , Masresha Balcha , Klinkenberg Don , Veldhuijzen Irene , Oteri Joseph , Dieng Boubacar , Ikeonu Obianuju Caroline , Meleh Sule , Musa Audu , Braka Fiona , Hahné Susan , Sanders E. A. M. , Hak Eelko
Published: March 2021

Background

From January to May 2019, large measles outbreaks affected Nigeria. Borno state was the most affected, recording 15,237 suspected cases with the state capital of Maiduguri having 1125 cases investigated and line-listed by March 2019. In Borno state, 22 of the 27 Local Government Areas (LGAs or Districts), including 37 internally displaced persons (IDPs) camps were affected. In response to the situation, an outbreak response immunization (ORI) campaign was conducted in the 13 most affected LGAs. In addition to conventional vaccination teams, special teams were deployed in security compromised areas, areas with migrants, and for nomadic and IDPs. Here we describe the outbreak and the ORI campaign. We also assess the measles-containing vaccine (MCV) coverage and vaccine effectiveness (VE) in order to quantify the population-level impact.

Methods

We reviewed the ORI activities, and conducted an analysis of the surveillance and the outbreak investigation reports. We assessed VE of MCV by applying the screening-method. Sensitivity analyses were also conducted to assess the effect of final classification of cases on the VE of MCV. The MCV coverage was assessed by a post-campaign coverage survey after completion of the ORI through a quantitative survey in the 12 LGAs that were accessible.

Results

Of the total 15,237 reported measles cases, 2002 cases were line-listed and investigated, and 737 were confirmed for measles by week 9 of 2019. Of the investigated cases 67.3% (n = 1348) were between 9 and 59 months of age. Among the 737 confirmed cases, only 9% (n = 64) stated being vaccinated with at least 1 dose of MCV. The overall VE for MCV was 98.4% (95%CI: 97.8–98.8). No significant differences were observed in the VE estimates of lab-confirmed and epi-linked cases when compared to the original estimates. The aggregated weighted vaccination coverage was 85.7% (95% CI: 79.6–90.1).

Conclusion

The experience in Borno demonstrates that adequate VE can be obtained in conflict-affected areas. In complex emergencies affected by measles outbreaks, health authorities may consider integration with other health strategies and the engagement of security personnel as part of the ORI activities.
Hepatocyte ploidy in cats with and without hepatocellular carcinoma
Authors: Post Jacqueline , Langohr Ingeborg M. , Webster Cynthia R.L. , Mottram Peter , Liu Chin-Chi , Johnston Andrea
Published: March 2021

Background

Domestic cats rarely develop hepatocellular carcinoma. The reason for the low prevalence is unknown. Reductions in hepatocellular ploidy have been associated with hepatic carcinogenesis. Recent work in mice has shown that livers with more polyploid hepatocytes are protected against the development of hepatocellular carcinoma. Hepatocyte ploidy in the domestic cat has not been evaluated. We hypothesized that ploidy would be reduced in peri-tumoral and neoplastic hepatocytes compared to normal feline hepatocytes. Using integrated fluorescence microscopy, we quantified the spectra of ploidy in hepatocellular carcinoma and healthy control tissue from paraffin embedded tissue sections.

Results

Feline hepatocytes are predominantly mononuclear and the number of nuclei per hepatocyte did not differ significantly between groups. Normal cats have a greater number of tetraploid hepatocytes than cats with hepatocellular carcinoma.

Conclusions

Total hepatocellular polyploidy in normal cat liver is consistent with values reported in humans, yet cellular ploidy (nuclei per cell) is greater in humans than in cats. Tetraploid cat hepatocytes are predominantly mononuclear.
A bifunctional enzyme belonging to cytochrome P450 family involved in the O-dealkylation and N-dealkoxymethylation toward chloroacetanilide herbicides in Rhodococcus sp. B2
Authors: Liu Hong-ming , Yuan Meng , Liu Ai-min , Ren Lei , Zhu Guo-ping , Sun Li-na
Published: March 2021

Background

The chloroacetamide herbicides pretilachlor is an emerging pollutant. Due to the large amount of use, its presence in the environment threatens human health. However, the molecular mechanism of pretilachlor degradation remains unknown.

Results

Now, Rhodococcus sp. B2 was isolated from rice field and shown to degrade pretilachlor. The maximum pretilachlor degradation efficiency (86.1%) was observed at a culture time of 5 d, an initial substrate concentration 50 mg/L, pH 6.98, and 30.1 °C. One novel metabolite N-hydroxyethyl-2-chloro-N-(2, 6-diethyl-phenyl)-acetamide was identified by gas chromatography-mass spectrometry (GC–MS). Draft genome comparison demonstrated that a 32,147-bp DNA fragment, harboring gene cluster (EthRABCDB2), was absent from the mutant strain TB2 which could not degrade pretilachlor. The Eth gene cluster, encodes an AraC/XylS family transcriptional regulator (EthRB2), a ferredoxin reductase (EthAB2), a cytochrome P450 monooxygenase (EthBB2), a ferredoxin (EthCB2) and a 10-kDa protein of unknown function (EthDB2). Complementation with EthABCDB2 and EthABDB2, but not EthABCB2 in strain TB2 restored its ability to degrade chloroacetamide herbicides. Subsequently, codon optimization of EthABCDB2 was performed, after which the optimized components were separately expressed in Escherichia coli, and purified using Ni-affinity chromatography. A mixture of EthABCDB2 or EthABDB2 but not EthABCB2 catalyzed the N-dealkoxymethylation of alachlor, acetochlor, butachlor, and propisochlor and O-dealkylation of pretilachlor, revealing that EthDB2 acted as a ferredoxin in strain B2. EthABDB2 displayed maximal activity at 30 °C and pH 7.5.

Conclusions

This is the first report of a P450 family oxygenase catalyzing the O-dealkylation and N-dealkoxymethylation of pretilachlor and propisochlor, respectively. And the results of the present study provide a microbial resource for the remediation of chloroacetamide herbicides-contaminated sites.