bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating the Impact of Reminiscence Therapy on Cognitive and Emotional Outcomes in Dementia Patients
Authors: Yanagida Nobuhiko , Yamaguchi Takumi , Matsunari Yuko
Published: June 2024

This study examines the impact of reminiscence therapy on cognitive and emotional well-being in institutionalized older patients with dementia. Conducted at the Long-Term Care Health Facility for the Elderly, the research involved 34 participants who underwent therapy sessions that included personalized discussions of past experiences. Using physiological markers such as electroencephalography alpha and beta waves, along with psychological measures such as the Hasegawa Dementia Scale—Revised, the study aimed to quantify the effects of the therapy. Although the results indicated positive correlations between alpha and beta waves, suggesting enhanced relaxation and cognitive engagement, improvements in Hasegawa Dementia Scale—Revised scores were not statistically significant, pointing to variability in therapeutic effectiveness among patients. Despite these mixed outcomes, the findings support the potential of reminiscence therapy as a non-pharmacological intervention to improve the quality of life of dementia patients, though they also underscore the necessity for further research to refine therapy protocols and enhance applicability.
Gynecological Laparoscopic Surgeries under Spinal Anesthesia: Benefits and Challenges
Authors: Major Attila L. , Jumaniyazov Kudrat , Jabbarov Ruslan , Razzaghi Mehdi , Mayboroda Ivanna
Published: June 2024

Objective: This prospective study investigated the feasibility of performing laparoscopic pelvic surgery under spinal anesthesia and analyzed the intraoperative side effects, like pain, nausea, and vomitus, of 915 patients. Methods: The implementation and performance of laparoscopic surgery under local anesthesia on 915 patients (out of a total of 3212 who underwent laparoscopic pelvic surgery under spinal anesthesia) were analyzed in relation to BMI (body mass index), obesity, pain during surgery, amount of intraperitoneal mmHg CO2 gas pressure, and surgical complications. Results: BMI > 30, intra-abdominal adhesions, increased duration of the operation, bleeding, and increased intraperitoneal CO2 pressure were statistically significant as the main causes of pain during laparoscopic surgery under spinal anesthesia. Underweight patients, on the other hand, had less pain when intra-abdominal pressure increased compared to those of normal weight. The appearance of pain, nausea, and vomitus occurred in 10.3% of patients, and these events were easy to manage and treat. They did not affect the surgeon’s work or the course of the operation. Conclusions: In light of these observations, we are proposing spinal anesthesia for laparoscopic surgery as the first choice in patients who have no contraindications. To the best of our knowledge, this clinical study constitutes the largest clinical observation and dataset concerning spinal anesthesia in laparoscopic pelvic surgery. Trial registration: ISRCTN38987, 10 December 2019.
Low-Carbon Monoxide Diffusing Capacity, Patient-Reported Measures and Reduced Nailfold Capillary Density Are Associated with Interstitial Lung Disease in Systemic Sclerosis
Authors: De Angelis Rossella , Cipolletta Edoardo , Francioso Francesca , Carotti Marina , Farah Sonia , Giovagnoni Andrea , Salaffi Fausto
Published: June 2024

The aim of this paper is to identify factors associated with interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) and build an algorithm to better define this association for a personalised application in clinical practice. Methods. A total of 78 SSc patients underwent HRCT to assess ILD. Demographic, clinical and laboratory variables were collected, focusing on those associated either directly or indirectly with lung involvement. The discriminant value of each variable was determined using the operating characteristic curves (ROC) and included in a model to estimate the strength of ILD association in SSc. Results. Thirty-three (42.31%) patients showed ILD on HRCT. DLco, M-Borg, GERD-Q and capillary density were significantly associated with the presence of ILD-SSc. A model including these variables had a coefficient of determination (R2) of 0.697. DLco had an AUC of 0.861 (p < 0.001) with a cut-off of ≤72.3% (sensitivity 78.8%, specificity 91.1%, +LR 8.86). The m-Borg Scale showed an AUC of 0.883 (p < 0.001) with a cut-off >2 (sensitivity 84.8%, specificity 82.2%, +LR 4.77), GERD-Q had an AUC of 0.815 (p < 0.001) with a cut-off >7 (sensitivity 72.7%, specificity 86.7%, +LR 5.45). The capillary density showed an AUC of 0.815 (p < 0.001) with a cut-off of ≤4.78 (sensitivity 87.9%, specificity 68.9%, +LR 2.82). Based on the pre-test probability values, these four variables were applied to Fagan’s nomogram to calculate the post-test probability of this association. Conclusions. Our study identified four associated clinical factors of ILD in SSc patients. Moreover, their inclusion in an algorithm for the post-test probability, tailored to the specific patients’ characteristics, significantly increases the ability to find out the presence of SSc-ILD.
ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia
Authors: Ogunbileje John O. , Harris Neil , Wynn Tung , Kashif Reema , Stover Brian , Osa-Andrews Bremansu
Published: June 2024

The ATP-binding cassette (ABC) transporters are a vast group of 48 membrane proteins, some of which are of notable physiological and clinical importance. Some ABC transporters are involved in functions such as the transport of chloride ions, bilirubin, reproductive hormones, cholesterol, and iron. Consequently, genetic or physiological disruption in these functions is manifested in various disease processes like cystic fibrosis, Tangier disease, and sideroblastic anemia. Among other etiologies, primary sideroblastic anemia results from a genetic mutation in the ATP-binding cassette-7 (ABCB7), a member of the ABC transporter family. There are not many articles specifically tackling the disease processes caused by ABC transporters in detail. Some testing methodologies previously reported in the available literature for investigating sideroblastic anemia need updating. Here, we expound on the relevance of ABCB7 as a clinically important ABC transporter and a rare participant in the disease process of Sideroblastic anemia. The other genetic and secondary etiologies of sideroblastic anemia, which do not involve mutations in the ABCB7 protein, are also described. We review the pathophysiology, clinical course, symptoms, diagnosis, and treatment of sideroblastic anemia with a focus on modern technologies for laboratory testing.
The Weight of Bariatric Surgery: Wernicke–Korsakoff Syndrome after Vertical Sleeve Gastrectomy—A Case Series
Authors: Gutiérrez-Rey Melissa , Castellar-Visbal Lily , Acevedo-Vergara Kaleb , Vargas-Manotas José , Rivera-Porras Diego , Londoño-Juliao Gloria , Castillo-Guerrero Brenda , Perdomo-Jiménez María-Camila , Bermúdez Valmore
Published: June 2024

In this case series, the simultaneous occurrence of Wernicke’s encephalopathy (WE) and dry beriberi was reported in three patients who underwent vertical sleeve gastrectomy (VSG) between May 2021 and May 2023. All patients were obese women who underwent vertical sleeve gastrectomy (VSG) without immediate postoperative complications, but two weeks later, hyperemesis and subsequent encephalopathy with ocular movement abnormalities and weakness were observed over the following thirty days. Patients were referred to neurology, where due to the high suspicion of WE, thiamine replacement therapy was initiated; meanwhile, diagnostic neuroimaging and blood tests were conducted. Neurological and psychiatric evaluations and neuroconduction studies were performed to assess the clinical evolution and present sequelae. One year after diagnosis, all patients exhibited affective and behavioral sequelae, anterograde memory impairment, and executive functioning deficits. Two patients met the criteria for Korsakoff syndrome. Additionally, peripheral nervous system sequelae were observed, with all patients presenting with sensorimotor polyneuropathy. In conclusion, Wernicke’s encephalopathy requires a high diagnostic suspicion for timely intervention and prevention of irreversible sequelae, which can be devastating. Therefore, raising awareness among medical professionals regarding the significance of this disease is essential.
Enhancing Landslide Detection with SBConv-Optimized U-Net Architecture Based on Multisource Remote Sensing Data
Authors: Song Yingxu , Zou Yujia , Li Yuan , He Yueshun , Wu Weicheng , Niu Ruiqing , Xu Shuai
Published: June 2024

This study introduces a novel approach to landslide detection by incorporating the Spatial and Band Refinement Convolution (SBConv) module into the U-Net architecture, to extract features more efficiently. The original U-Net architecture employs convolutional layers for feature extraction, during which it may capture some redundant or less relevant features. Although this approach aids in building rich feature representations, it can also lead to an increased consumption of computational resources. To tackle this challenge, we propose the SBConv module, an efficient convolutional unit designed to reduce redundant computing and enhance representative feature learning. SBConv consists of two key components: the Spatial Refined Unit (SRU) and the Band Refined Unit (BRU). The SRU adopts a separate-and-reconstruct approach to mitigate spatial redundancy, while the BRU employs a split-transform-and-fuse strategy to decrease band redundancy. Empirical evaluation reveals that models equipped with SBConv not only show a reduction in redundant features but also achieve significant improvements in performance metrics. Notably, SBConv-embedded models demonstrate a marked increase in Recall and F1 Score, outperforming the standard U-Net model. For instance, the SBConvU-Net variant achieves a Recall of 75.74% and an F1 Score of 73.89%, while the SBConvResU-Net records a Recall of 70.98% and an F1 Score of 73.78%, compared to the standard U-Net’s Recall of 60.59% and F1 Score of 70.91%, and the ResU-Net’s Recall of 54.75% and F1 Score of 66.86%. These enhancements in detection accuracy underscore the efficacy of the SBConv module in refining the capabilities of U-Net architectures for landslide detection of multisource remote sensing data. This research contributes to the field of landslide detection based on remote sensing technology, providing a more effective and efficient solution. It highlights the potential of the improved U-Net architecture in environmental monitoring and also provides assistance in disaster prevention and mitigation efforts.
From Reading to Design of the “[entra]mar”: The Role of Urban Morphology in Architectural Pedagogy and Design
Authors: Proença Sérgio Barreiros , Valente Monteiro Cristiana , Dal Cin Francesca
Published: June 2024

This article presents the pedagogical process of reading and designing in the design studio course in the first semester of the fourth year in Architecture and Urbanism (2020–2021) held at the Lisbon School of Architecture of the Universidade de Lisboa. The research by design results are inscribed in the Embryo Project “[entra]mar Sea Intertwined City. Interpretation and Design of Portuguese Seashore Streets Vulnerable to Sea Level Rise”, funded by the FCT exploratory projects through CIAUD—Research Center in Architecture, Urbanism and Design at the Lisbon School of Architecture, Universidade de Lisboa (Portugal). The aim of this article is to demonstrate the usefulness of urban morphology in the reading and design process of an urban seafront vulnerable to extreme weather events. The approach to the “Sesimbra [entra]mar” in a pedagogical context confirms morphological interpretation as a key instrument for the formation of students and is consequently valuable for the practice of architecture and urbanism.
The Impact of Urban Renewal on Spatial–Temporal Changes in the Human Settlement Environment in the Yangtze River Delta, China
Authors: Zheng Linzi , Zheng Yongjie , Fu Zhengbo
Published: June 2024

China’s rapid urbanization drive, marked by extensive urban renewal projects, necessitates a meticulous examination of their transformational impact on the human settlement environment (HSE) across urban landscapes. This study investigates the impact of China’s urban renewal progress on the spatial–temporal changes in the HSE from 2009 to 2019, using data from 40 prefecture-level cities in the Yangtze River Delta. Our findings reveal an overall positive relationship between the spatio–temporal evolution of urban renewal and the HSE, suggesting that urban renewal projects have had a beneficial impact, particularly following the announcement of China’s New Urbanization policy in 2014. However, the extent of this positive impact varied among different areas, with more significant improvements observed in core cities and economically developed areas. Additionally, our study uncovered significant variations in how urban renewal influenced the HSE over time. We found that the primary influencing factor shifted from material renewal to industrial renewal. These findings offer valuable insights for improving the HSE during urban renewal processes, both in China and other regions undergoing rapid urbanization.
Long-Term Analysis of Spatial–Temporal Variation in Ecological Space Quality within Urban Agglomeration in the Middle Reaches of the Yangtze River
Authors: Zhang Ruijiao , Wang Zhengxiang , Wei Lifei , Zhang Mingda , Lu Qikai , Chen Bangqing
Published: June 2024

The assessment of ecological space quality (ESQ) and its spatio-temporal change monitoring are crucial for regional ecological management and sustainable development. However, there are few studies on how to construct a comprehensive ESQ assessment system to reveal the spatial and temporal change patterns of ESQ over a long time series. Therefore, this study constructs an ESQ evaluation model with comprehensive ecological characteristics to quantitatively assess the spatio-temporal dynamics of ESQ from 2001 to 2020 based on policy objectives and public demands, using the urban agglomeration in the middle reaches of the Yangtze River as an example. The results show that, in the past 20 years, the mean value of ESQ in urban agglomeration has decreased (−0.179·year−1), and the overall ESQ is dominated by a good level. The ESQ has shifted from improvement (2001–2010) to deterioration (2010–2020) and shows the spatial distribution characteristics of “high in the periphery and center, low in the interior”. From the trend of change, the degraded area of ESQ is greater than the improved area, and the degraded area of ESQ will increase in the future compared with the trend of 2001–2020. The distribution of ESQ has a significant spatial agglomeration and scale effect. The hot spots of ESQ at the town scale are mainly concentrated in the central part of urban agglomeration and mountainous areas in the periphery. The cold spots are mainly concentrated in the surrounding areas of central cities (Wuhan, Changsha, and Nanchang). The proposed assessment framework can be used to quantify spatial and temporal changes in ESQ and identify potential ecological space management issues, providing basic information for implementing ecological space protection, restoration, and developing adaptive ESQ management measures. The research results are of significant importance for ecosystem restoration and long-term development in the Yangtze River Basin.
Deciphering Tourism’s Role in Antarctica’s Geosocial Concerns through Data Mining Techniques
Authors: Calderón-Fajardo Víctor , Puig-Cabrera Miguel , Rodríguez-Rodríguez Ignacio
Published: June 2024

This study explores the changing dynamics of tourism in Antarctica, focusing on the impact of digitalisation and User-Generated Content on platforms like Tripadvisor. It aims to understand how online reviews influence perceptions and decisions to visit Antarctica, a region known for its pristine environment and status as ‘the last frontier’. Utilising Environmental Perception and Behaviour Geography (EPBG) principles, this research conducts a quantitative analysis of reviews from potential and current travellers. Through text mining, topic modelling, sentiment analysis, and Natural Language Processing (NLP), it investigates the emotional and perceptual discourse surrounding Antarctic tourism and its alignment with Agenda 2030 and Sustainable Development Goals. The findings reveal a detailed narrative of sustainability challenges and the emotional geography related to tourism in Antarctica, highlighting emotions such as happiness, anger, surprise, fear, disgust, and sadness among visitors. This study uncovers differences in perception based on visitors’ backgrounds, noting that individuals from nature-focused cities display strong environmental concerns, whereas those from advanced urban centres show a more positive attitude. This research contributes to the understanding of EPBG, text mining, and NLP, offering insights into sustainable tourism practices in Antarctica.
Construction and Optimization of Ecological Security Pattern Network Based on the Supply–Demand Ratio of Ecosystem Services: A Study from Chengdu–Chongqing Economic Circle, China
Authors: Guan Dongjie , Chang Qiongyao , Zhou Lilei , Zhu Kangwen , Peng Guochuan
Published: June 2024

The exploration of ecological security patterns (ESPs) can help people find those areas that are in urgent need of restoration, which is an effective way to realize ecological protection. It is of utmost significance for promoting regional sustainable development to construct ESP and put forward sub-regional optimization suggestions based on the supply and demand ratio of ecosystem services (ESs). In this paper, we assessed the level of supply and demand for five ESs based on multi-source data in 2020 with the help of InVEST, ArcGIS, and IUEMS. Based on the results of supply and demand, we calculated the supply and demand ratio of ESs and extracted the ecological source areas (ESAs) on this basis. Then, we used the Linkage Mapper tool to construct the ESP based on the principle of the minimum cumulative resistance (MCR) model and circuit theory in the Chengdu–Chongqing economic circle (CCEC). Our results indicated that there were apparent spatial differences in the supply and demand of five ESs. There were 35 ESAs in the ESP network, covering an area of about 7914 km2, and most of their land use types were woodland. The CCEC was interconnected by a network of 91 ecological corridors (ECs), spanning a total length of approximately 10,701 km. From the ECs, we extracted 29 ecological pinch points (EPPs) and 16 ecological barrier points (EBPs), which each accounted for about 0.3% of the planned area of the CCEC. Finally, we divided the ecological spaces into four types and put forward the corresponding optimization suggestions. Among them, the proportion of ecological restoration area was 7.7%, which was located in Chengdu City, northwest of the study area. The findings of this paper can give some theoretical guidance and serve as a reference for making decisions in the pursuit of ecological civilization in this region.
Effects of the Implementation Intensity of Ecological Engineering on Ecosystem Service Tradeoffs in Qinghai Province, China
Authors: Yan Ke , Zhao Bingting , Li Yuanhui , Wang Xiangfu , Jin Jiaxin , Jiang Jiang , Dong Wenting , Wang Rongnv , Yang Hongqiang , Wang Tongli , Wang Weifeng
Published: June 2024

Ecological engineering (EE) has a profound impact on land-use dynamics, leading to alterations in ecosystem services (ESs). However, an appropriate EE implementation intensity that can balance the tradeoffs associated with altered ESs well has always been a concern for researchers and policymakers. In this study, we set the transition probability of farmland, bare land, and desertification land to forest and natural shrub, with 2010–2020 as the natural implementation scenario, as 10% for the low-intensity implementation scenario (LIS), 30% for the medium-intensity scenario, and 50% for the high-intensity scenario. The patch-generating land-use simulation (PLUS) model was used to project land-use patterns and the Integrated Valuation of Ecosystem Service and Tradeoffs (InVEST) model was used to simulate changes in the quality of ESs under four EE implementation intensities in 2030. We then performed a quantitative tradeoff analysis on the dominant ESs under four scenarios and used the production possibility frontier (PPF) curve to identify the optimal EE implementation intensity scenario. Our results indicated that an increase in EE implementation intensity would lead to an increase in soil retention, water purification, habitat quality, and carbon storage, but also to a decrease in water yield, aggravating the tradeoffs between water yield and other ESs. In all EE implementation intensity scenarios, the LIS had the lowest tradeoff intensity index and balanced ESs well, and thus was the optimal EE implementation scenario in Qinghai province. Our results provide knowledge to help decision makers select the appropriate EE intensity to maintain sustainable development. The integrated methodology can also be applied in other conservation regions to carry out practical land management.
Shopping Mall Site Selection Based on Consumer Behavior Changes in the New Retail Era
Authors: Zhou Ruibin , Wang Chenshuo , Bao Dongting , Xu Xiaolan
Published: June 2024

As a product of the development of e-commerce over a specific period of time, the “new retail model” breaks the barriers between the traditional retail industry and e-commerce. Supported by Internet technology, it builds a new business model of “physical store + e-commerce + logistics” through the integration of online, offline, and logistics, which also leads to a great change in consumer behavior. Therefore, in order to meet consumer demand and achieve the long-term development of shopping malls, while taking into account the fair allocation of urban space resources, the indicators and methods of shopping mall site selection evaluation in the new retail era will be significantly different from traditional shopping mall site selection decisions. In this paper, the Wuhan East Lake Hi-Tech Zone is selected as the research object, and a comprehensive AHP-GIS assessment model is proposed. By investigating the impact of consumers’ behavioral changes on shopping mall location in the new retail era, a suitability evaluation system containing eight evaluation indicators is constructed, and the weights of each factor are determined using hierarchical analysis. At the same time, GIS is used to process the spatial analysis of the indicators, and combined with the weights of the factors, superposition analysis and quantitative research are carried out. Finally, based on the correlation analysis between ratings and customer flow, the suitability evaluation results are further supported in order to provide a more objective and scientific basis for the location of shopping malls from the perspective of the change in consumer behavior under the new retail model, and to put forward universal suggestions for the construction and development of shopping malls in the future.
Dynamic Integrated Ecological Assessment along the Corridor of the Sichuan–Tibet Railway
Authors: Ji Cuicui , Yang Hengcong , Pei Xiangjun , Zhang Xiaochao , Chen Lichuan , Liang Dan , Cao Yiming , Pan Jianping , Chen Maolin
Published: June 2024

Engineering activities along the Sichuan–Tibet Railway (STR) could cause land degradation and threaten the surrounding ecological security. It is crucial to evaluate the integrated land ecology during and after the construction of this project. This study assesses the land ecology along the STR corridor from 2000 to 2022 using a transfer matrix, the analytic hierarchy process (AHP), and the PSR-TOPSIS model. The main results are as follows: (1) The novel comprehensive ecological assessment process including nine indicators is feasible. (2) The high-quality land ecological, surface vegetation, and environmental regions were concentrated in Ya’an and Nyingchi, whereas the low-quality regions were situated in Qamdo and Garze Tibetan Autonomous Prefecture. (3) There was an overall decline in the integrated land ecological quality along the STR from 2000 to 2022. While it steadily improved in the Ya’an and Nyingchi regions from 2010 to 2022, it continued to decline around the Qamdo region. (4) The most degraded land-use type during the 22 years was grassland, and farmland was the most secure land-use type. Overall, spatial analyses and examinations of residue disposal sites suggested that these locations have negatively impacted integrated land ecology since the beginning of the STR construction project. Our findings have implications for preserving the ecological ecosystem and ensuring the sustainability of the STR construction project.
Physical Activity during Pregnancy and Risk of Gestational Diabetes Mellitus: A Meta-Review
Authors: Rute-Larrieta Carmen , Mota-Cátedra Gloria , Carmona-Torres Juan Manuel , Mazoteras-Pardo Victoria , Barroso-Corroto Esperanza , Navarrete-Tejero Carlos , Zografakis-Sfakianakis Michail , Patelarou Athina , Martins Maria Manuela , Faria Ana da Conceinçao Alves , Laredo-Aguilera José Alberto
Published: June 2024

Background: Nowadays, pregnant women require more individualized attention in their assistance process during pregnancy. One of the aspects that requires the most focus is the suitability of carrying out physical activity. The objective of this meta-review is to find out the effects of physical activity during pregnancy on the incidence of GDM compared to women who do not perform physical activity. Methods: A search was conducted in Cochrane, CSIC, Ebscohost, Proquest, Pubmed, Scielo, and Scopus. The search focused on systematic reviews and meta-analyses published in the last five years. The AMSTAR-2 scale was used as a quality assessment tool for the final sample. Results: A total of 18 systematic reviews and meta-analyses were included. Sixteen of them found out that physical activity during pregnancy has preventive effects for GDM compared with women who lacked physical activity. Among the studies, we found a reduction in the risk of GDM of between 24% and 38% and odds ratios ranging between 0.39 and 0.83 calculated for a 95% CI. Only two studies did not find statistically significant effects. Other variables such as type and duration of physical activity, overweight and obesity, gestational age, etc., were also considered. Conclusions: Physical activity prevents the incidence of GDM. The main characteristics that enhance this preventive effect are starting at the initial stages of pregnancy and maintaining during the whole pregnancy as well as combining strength and aerobic exercise at a low to moderate intensity.
Enhanced Citric Acid Production through Aspergillus niger: Insights from Fermentation Studies Using Sugarcane Molasses
Authors: Khurshid Samina , Ashraf Hamad , Hussain Tanveer , Iqbal Muhammad , Qureshi Huma , Anwar Tauseef , Salmen Saleh H. , Ansari Mohammad Javed
Published: June 2024

The production of citric acid, a vital agricultural commodity utilized across various industries such as food, beverages, pharmaceuticals, agriculture, detergents, and cosmetics, predominantly relies on microbial fermentation, with Aspergillus niger accounting for approximately 90% of global production. In this study, we aimed to optimize the key factors influencing citric acid production, with a focus on strains, fermentation techniques, and carbon sources, particularly sugarcane molasses. A. niger, sourced from the Botany department/Biotechnology laboratories at Govt. College of Science, Lahore, was employed for citric acid production. The process involved inoculum preparation through spore collection from 3 to 5 days of cultured PDA slants. The fermentation medium, comprising cane molasses with a 15% sugar concentration, was meticulously prepared and optimized for various factors, including magnesium sulfate, potassium ferrocyanide, time of addition of potassium ferrocyanide, ammonium oxalate, and calcium chloride. Our optimization results shed light on the significant impact of different factors on citric acid production. For instance, the addition of 0.4 g/L magnesium sulfate led to a maximum yield of 75%, while 2 g/L potassium ferrocyanide, added at 24 h, achieved a yield of 78%. Remarkably, ammonium oxalate, at a concentration of 10 g/L, resulted in a notable 77% yield. Conversely, the addition of calcium chloride exhibited negligible effects on citric acid production, with the control group yielding more at 78%. Our study underscores the potential for optimizing factors to enhance citric acid production by A. niger in submerged fermentation. These findings highlight the pivotal role of magnesium sulfate, potassium ferrocyanide, and ammonium oxalate in augmenting citric acid yields while emphasizing the minimal impact of calcium chloride. Ultimately, these insights contribute to advancing our understanding of microbial citric acid biosynthesis, providing valuable implications for industrial applications and future research endeavors.
Application of a Video Head Impulse Test in the Diagnosis of Vestibular Neuritis
Authors: Jasinska-Nowacka Agnieszka , Niemczyk Kazimierz
Published: June 2024

In patients presenting in the emergency department with acute vertigo, a rapid and accurate differential diagnosis is crucial, as posterior circulation strokes can mimic acute vestibular losses, leading to inappropriate treatment. The diagnosis of vestibular neuritis is made based on the clinical manifestation and a bedside otoneurological assessment. In the clinical examination, an evaluation of the vestibulo-ocular reflex is the key element; however, the accuracy of the bedside head impulse test depends on the clinician’s experience. Thus, new diagnostic methods are needed to objectify and facilitate such rapid vestibular evaluations. The aim of our paper is to provide a comprehensive review of the video head impulse test’s application in the diagnosis of vestibular neuritis. Numerous studies have reported advantages that make this method helpful in detailed otoneurological evaluations; in contrast to the bedside head impulse test, it enables an analysis of all six semicircular canals function and records the covert corrective saccades, which are invisible to the naked eye. As a portable and easy diagnostic tool, it is known to improve the diagnostic accuracy in patients with acute vertigo presenting in the emergency department. Moreover, as it evaluates the vestibulo-ocular reflex across different frequencies, as compared to caloric tests, it can be used as an additional test that is complementary to videonystagmography. Recently, several papers have described the application of the video head impulse test in follow-up and recovery evaluations in patients with vestibular neuritis.
The Efficacy of the Smartphone App for the Self-Management of Low Back Pain: A Systematic Review and Assessment of Their Quality through the Mobile Application Rating Scale (MARS) in Italy
Authors: Scala Luca , Giglioni Gloria , Bertazzoni Luca , Bonetti Francesca
Published: June 2024

Smartphone apps for self-management are valuable tools to help manage low back pain (LBP) patients. The purposes of this systematic review were to (a) summarize the available studies on the efficacy of smartphone apps for self-management of LBP and (b) identify free applications available in Italy that offer strategies for LBP self-management and provide a qualitative assessment using the Mobile Application Rating Scale (MARS). According to the Prisma Checklist, six bibliographic databases were searched with the keywords ‘low back pain’, ‘mobile application’, ‘smartphone’, and ‘telemedicine’. In total, 852 records were screened, and 16 were included in the systematic review. Of the six RCTs included, four reported a statistically significant decrease in pain in favor of the app group, and two RCTs did not. Only in a non-RCT was there an increase in the disability score. In the application research conducted on mobile stores, we identified and rated 25 applications through MARS. The overall scores ranged from 1.93 to 3.92 for the IOS app and 1.73 to 4.25 for the Play Store app. The findings suggest that few apps meet satisfying quality, content, and functionality criteria for LBP self-management.
Machine Learning and Deep Learning Methods for Fast and Accurate Assessment of Transthoracic Echocardiogram Image Quality
Authors: Nazar Wojciech , Nazar Krzysztof , Daniłowicz-Szymanowicz Ludmiła
Published: June 2024

High-quality echocardiogram images are the cornerstone of accurate and reliable measurements of the heart. Therefore, this study aimed to develop, validate and compare machine learning and deep learning algorithms for accurate and automated assessment of transthoracic echocardiogram image quality. In total, 4090 single-frame two-dimensional transthoracic echocardiogram images were used from apical 4-chamber, apical 2-chamber and parasternal long-axis views sampled from 3530 adult patients. The data were extracted from CAMUS and Unity Imaging open-source datasets. For every raw image, additional grayscale block histograms were developed. For block histogram datasets, six classic machine learning algorithms were tested. Moreover, convolutional neural networks based on the pre-trained EfficientNetB4 architecture were developed for raw image datasets. Classic machine learning algorithms predicted image quality with 0.74 to 0.92 accuracy (AUC 0.81 to 0.96), whereas convolutional neural networks achieved between 0.74 and 0.89 prediction accuracy (AUC 0.79 to 0.95). Both approaches are accurate methods of echocardiogram image quality assessment. Moreover, this study is a proof of concept of a novel method of training classic machine learning algorithms on block histograms calculated from raw images. Automated echocardiogram image quality assessment methods may provide additional relevant information to the echocardiographer in daily clinical practice and improve reliability in clinical decision making.
Effect of Substrate Preheating Temperature on the Microstructure and Properties of Laser Cladding Fe/TiC Composite Coating
Authors: Shi Wenqing , Cheng Cai , Zhang Bingqing , An Fenju , Li Kaiyue , Xiong Zhaoting , Xie Yuping , He Kuanfang
Published: June 2024

In this study, Fe/TiC composite coating was fabricated on the surface of 65Mn steel using substrate preheating combined with laser cladding technology. In order to characterize the impact of various preheating temperatures, four coatings were fabricated on a 65Mn substrate using laser cladding at different temperatures (ambient temperature, 100 °C, 200 °C, and 300 °C). The microstructures and properties of four Fe/TiC composite coatings were investigated using SEM, XRD, EDS, a Vickers microhardness meter, a wear tester, and an electrochemical workstation. The research results show that the cladding angle of the Fe/TiC composite coating initially increases and then decreases as the substrate preheating temperature rises. The solidification characteristics of the Fe/TiC composite coating structure are not obviously changed at substrate preheating temperatures ranging from room temperature to 300 °C. However, the elemental distribution within the cladding layer was significantly influenced by the preheating temperature. An increase in the preheating temperature led to a more uniform elemental distribution. Regarding the comprehensive properties, including hardness, wear characteristics, and corrosion resistance, the optimum substrate preheating temperature for the cladding layer was found to be 300 °C.
New Insights into the Application of Biocompatible (Un)Modified TiO2 and TiO2-ZrO2 Oxide Fillers in Light-Curing Materials
Authors: Siwińska-Ciesielczyk Katarzyna , Andrzejczak Angelika , Jesionowski Teofil , Gierz Łukasz , Marcinkowska Agnieszka , Robakowska Mariola
Published: June 2024

A novel UV-light-curable poly(ethylene glycol) diacrylate matrix composite material with unmodified and methacryloxyl-grafted TiO2 and TiO2-ZrO2 systems was developed and tested as a potential coating material for medical components. The main goal of the research was to evaluate how the addition of (un)modified inorganic oxide fillers affects the properties of the composition (viscosity, UV/Vis spectra), the kinetics of photocuring (photo-DSC), and the morphological (SEM), physicochemical, and thermal properties (DSC, TGA) of the resulting composites. The applied filler functionalization process decreased their polarity and changed their size, BET surface area, and pore volume, which influenced the viscosity and kinetics of the photocurable system. In addition, the addition of synthesized fillers reduced the polymer’s glass transition temperature and increased its thermal stability. It was also observed that additional UV irradiation of the tested composite changed its surface, resulting in hydrophobic properties (with the addition of 7 wt.% filler, an increase in the contact angle by more than 45% was observed).
Cobalt–Imidazole Complexes: Effect of Anion Nature on Thermochemical Properties
Authors: Netskina Olga V. , Sukhorukov Dmitry A. , Dmitruk Kirill A. , Mukha Svetlana A. , Prosvirin Igor P. , Pochtar Alena A. , Bulavchenko Olga A. , Paletsky Alexander A. , Shmakov Andrey G. , Suknev Alexey P. , Komova Oxana V.
Published: June 2024

A solvent-free method was proposed for the synthesis of hexaimidazolecobalt(II) nitrate and perchlorate complexes—[Co(C3H4N2)6](NO3)2 and [Co(C3H4N2)6](ClO4)2—by adding cobalt salts to melted imidazole. The composition, charge state of the metal, and the structure of the resulting complexes were confirmed by elemental analysis, XPS, IR spectroscopy, and XRD. The study of the thermochemical properties of the synthesized complexes showed that [Co(C3H4N2)6](NO3)2 and [Co(C3H4N2)6](ClO4)2 are thermally stable up to 150 and 170 °C, respectively. When the critical temperature of thermal decomposition is reached, oxidative two-stage gasification is observed. In this case, the organic component of the [Co(C3H4N2)6](NO3)2 complex undergoes almost complete gasification to form Co3O4 with a slight admixture of CoO, which makes it attractive as a component of gas-generation compositions, like airbags.
Investigating the High-Temperature Bonding Performance of Refractory Castables with Ribbed Stainless-Steel Bars
Authors: Plioplys Linas , Antonovič Valentin , Boris Renata , Kudžma Andrius , Gribniak Viktor
Published: June 2024

Refractory materials containing calcium aluminate cement (CAC) are commonly used in the metallurgical and petrochemical industries due to their exceptional mechanical resistance, even at temperatures exceeding 1000 °C, and do not require additional reinforcement. This study seeks to advance this practice by developing ultra-high-performance structures that offer building protection against fire and explosions. Such structures require bar reinforcement to withstand accidental tension stresses, and the bond performance becomes crucial. However, the compressive strength of these materials may not correlate with their bond resistance under high-temperature conditions. This study investigates the bond behavior of ribbed stainless austenitic steel bars in refractory materials typical for structural projects. The analysis considers three chamotte-based compositions, i.e., a conventional castable (CC) with 25 wt% CAC, a medium-cement castable (MCC) with 12 wt% CAC, a low-cement castable (LCC), and a low-cement bauxite-based castable (LCB); the LCC and LCB castables contain 7 wt% CAC. The first three refractory compositions were designed to achieve a cold compressive strength (CCS) of 100 MPa, while the LCB mix proportions were set to reach a CCS of 150 MPa. Mechanical and pull-out tests were conducted after treatment at 400 °C, 600 °C, 800 °C, and 1000 °C; reference specimens were not subjected to additional temperature treatment. This study used X-ray fluorescence (XRF), X-ray diffraction (XRD), and scanning electron microscopy (SEM) methods to capture the material alterations. The test results indicated that the bonding resistance, expressed in terms of the pull-out deformation energy, did not directly correlate with the compressive strength, supporting the research hypothesis.
Iron Tailings as Mineral Fillers and Their Effect on the Fatigue Performance of Asphalt Mastic
Authors: Cui Yaning , Si Chundi , Li Song , Jia Yanshun , Guo Bin
Published: June 2024

Incorporating iron tailings (ITs) into asphalt represents a new method for waste-to-resource conversion. The objective of this study is to evaluate the fatigue performance of ITs as fillers in asphalt mastic and investigate the interaction and interfacial adhesion energy between asphalt and ITs. To achieve that, the particle size distributions of two ITs and limestone filler (LF) were tested through a laser particle size analyzer; the morphology and structure characteristics were obtained by scanning electronic microscopy (SEM), the mineral compositions were conducted through X-ray diffraction (XRD), and the chemical compositions were tested through X-ray Fluorescence Spectrometer (XRF). Furthermore, the fatigue properties of asphalt mastic and the interaction between asphalt binder and mineral fillers (ITs and LFs) were evaluated by Dynamic Shear Rheometer (DSR). The interfacial adhesion energy between ITs and asphalt binder were calculated through molecular dynamics simulation. In the end, the correlation between the test results and the fatigue life is established based on the gray correlation analysis, the environmental and economic benefits of iron tailings asphalt pavement are further evaluated. The results show that the particle size distribution of ITs is concentrated between 30 μm and 150 μm, and the main component is quartz. ITs have rich angularity and a higher interaction ability with asphalt. The adhesion energy of iron tailings filler to asphalt is less than that of limestone. The correlation degree of the interfacial adhesion energy and interaction between asphalt and mineral filler with asphalt mastic fatigue life is close to 0.58. Under the combined action of interaction ability and interfacial adhesion energy, the fatigue life of IT asphalt mastic meets the requirements. ITs as a partial replacement for mineral fillers in asphalt pavement have great environmental and social effectiveness.
Bipolar Nb3Cl8 Field Effect Transistors
Authors: Lu Yixiang , Zhao Kai , Zhang Tongyao , Dong Baojuan
Published: June 2024

Field effect transistors based on few-layered van der Waals transition metal halide (TMH) Nb3Cl8 are studied in this work. Few-layered Nb3Cl8 exhibits typical N-type semiconducting behavior controlled by a Si gate, with the electrical signal enhancing as the thickness increases from 4.21 nm to 16.7 nm. Moreover, we find that the tunability of few-layered Nb3Cl8 FETs’ electrical transport properties can be significantly augmented through the use of an ionic liquid gate (or electrical double layer, EDL). This enhancement leads to a substantial increase in the on–off ratio by approximately a factor of 102, with the transfer curve modulated into a bipolar fashion. The emergence of such bipolar tunable characteristics in Nb3Cl8 FETs serves to enrich the electronic properties within the transition metal halide family, positioning Nb3Cl8 as a promising candidate for diverse applications spanning transistors, logic circuits, neuromorphic computing and spintronics.
A Novel Modified Discrete Differential Evolution Algorithm to Solve the Operations Sequencing Problem in CAPP Systems
Authors: Alvarez-Flores Oscar Alberto , Rivera-Blas Raúl , Flores-Herrera Luis Armando , Rivera-Blas Emmanuel Zenén , Funes-Lora Miguel Angel , Niño-Suárez Paola Andrea
Published: June 2024

Operation Sequencing (OS) is one of the most critical tasks in a CAPP system. This process could be modelled as a combinatorial problem where finding a suitable solution within a reasonable time interval is difficult. This work implements a novel Discrete Differential Evolution Algorithm (DDEA) to solve the OS problem, focusing on parts of up to 76 machining operations; the relationships among operations are represented as a directed graph; the contributions of the DDEA are as follows: (1) operates with a discrete representation in the space of feasible solutions; (2) employs mutation and crossover operators to update solutions and to reduce machining and setup costs, (3) possess a local search strategy to achieve better solutions, and (4) integrates a statistical method based on quantiles to measure the quality and likelihood for an achieving a solution. To demonstrate the efficiency and robustness of the DDEA, five prismatic parts with different numbers of machining operations as benchmarks to address the OS problem were selected. The results generated the same OS for parts with a few machining operations (up to 23 machining operations). Conversely, for parts with more machining operations, the DDEA needs more runs to achieve the best solution.
The Duality of Psychological and Intrinsic Time in Artworks
Authors: Milovanović Miloš , Saulig Nicoletta
Published: June 2024

The paper investigates the problem of the time arrow in terms of artistic creation. The statistical model of artwork signal processing is established in order to identify a duality relation between psychological and intrinsic time. The intrinsic time is linked to the time operator of wavelets, and the psychological one is metaphorically related to the spatial domain of an artwork. The increase of irreducible randomness along the timeline is formulated by the second law of thermodynamics. The dual statement concerns an increase in statistical complexity, which is the definition of self-organization. In that manner, two arrows of time which are opposed and dual to each other are recognized. The authors have indicated a link to the theory of musical forms, the originality issue, and the perspective problem. Some repercussions for art theory, neuroaesthetics, and psychophysics have also been implied.
The Factors Influencing User Satisfaction in Last-Mile Delivery: The Structural Equation Modeling Approach
Authors: Vrhovac Vijoleta , Dakić Dušanka , Milisavljević Stevan , Ćelić Đorđe , Stefanović Darko , Janković Marina
Published: June 2024

The primary goal of this research is to identify which factors most significantly influence customer satisfaction in the last-mile delivery (LMD) process. The sample comprised 907 participants (63.4% female) with a mean age of 34.90. All participants completed three questionnaires regarding LMD, customer satisfaction, and trust in courier service. Furthermore, participants answered questions related to significant aspects of the delivery process: speed, price, and courier call before delivery. To determine which factors most significantly influence customer satisfaction in LMD, structural equation modeling (SEM) was applied. The tested SEM model showed a good fit. The results indicated that within the LMD dimension, visual appeal was a significant predictor in a negative direction, and all other LMD dimensions (except parcel tracking) were positive and significant predictors of customer satisfaction. Trust in courier service, delivery price, speed, and courier call before delivery were statistically significant predictors of customer satisfaction in last-mile delivery, all in a positive direction.