bluuebunny/crossref_metadata_2025 huggingface dataset:
Parental attitudes and family helmet use for all-terrain vehicles and bicycles
Authors: Wymore Cole , Denning Gerene , Hoogerwerf Pamela , Wetjen Kristel , Jennissen Charles
Published: June 2020

Background

Helmets prevent head trauma in both all-terrain vehicle (ATV) and bicycle crashes. This pilot study’s objective was to compare family helmet use and participant attitudes regarding helmets for ATVs versus bicycles.

Methods

A convenience sampling of adults attending a 2017 university-sponsored health fair who had at least one child < 18 years living at home were surveyed. Demographics, frequency of helmet use, and information about factors influencing helmet use were collected. Descriptive (frequencies) and bivariate (Fisher’s exact test) analyses were performed. Qualitative themes of written responses were also examined.

Results

Subjects (N = 98) were 26–57 years old (mean 40 years). Three-quarters (76%) were female. The percentage always wearing a helmet riding bicycles was 63% (subjects), 58% (spouses/partners), and 51% (children), compared to 11, 14 and 37% on ATVs, respectively. Moreover, the percentage never wearing a helmet while on an ATV was 68% for subjects, 71% for spouses, and 47% for children. Despite helmet use differences between bicycles and ATVs, the importance of children wearing a helmet on these vehicles was rated highly and equally important, 9.28 and 9.58 on a 1–10 scale, respectively. Higher proportions of subjects’ oldest children wore a bike helmet 100% of the time if at least one parent always wore a helmet (81%), compared to children whose parents both wore helmets < 100% of the time or didn’t ride (21%) (p < 0.0001). The proportion of children wearing ATV and bicycle helmets less than 100% of the time was significantly higher if parents reported barriers to effectively enforcing helmet use than if they did not (p = 0.04 and p = 0.004, respectively). Many reported a “strict no helmet, no bike/ATV riding rule” as being most effective in getting their children to always wear a helmet.

Conclusions

This study is the first to explore family helmet use while riding bicycles vs ATVs. Although parent’s belief in the importance of helmet use was high for both, helmet use was greater when riding bicycles. Further research is needed to better understand the social and environmental influences that shape parental helmet attitudes and practices in order to improve safety interventions for increasing pediatric helmet use.
Evaluating teen driving knowledge and behaviors following educational outreach
Authors: Monroe Kathy , Nichols Michele , Crew Marie , Brown Leslie , King William
Published: June 2020

Background

Teen driving educational events are an effective strategy to increase adolescent drivers’ awareness of safe driving practices. The objectives of this study were to evaluate changing rates of self-reported driving practices and knowledge of the state Graduated Driver Licensing laws (GDL) by teens over a nine-year period in a single state.

Methods

This was a prospective observational study of high school students ages 14 to 19 years old. Paper surveys were sent to the high schools participating in teen driving educational events (9 schools in 2009 and 4 schools in 2018). Students in those schools completed surveys prior to the events. Students completing the anonymous survey were invited to the event. Questions evaluated awareness of state GDL and safe and risky driving behaviors. Statistical comparisons of survey answers from 2009 to 2018 were analyzed using the z test of proportions (2 tailed, alpha 0.05).

Results

A total of 397 students participated in 2018 with ages ranging from 14 to 19 years. Racial distribution was 81% white, 14% black, and there were 57% female participants. Only 69% (n = 273) reported “always” wearing their seatbelt. When asked about high risk behaviors, 78% (n = 309) of adolescents reported they personally “never” text while driving; 97% (385); never drive after drinking, and 87% (n = 344) never ride with someone who has been drinking. Compared to 2009 participants (1304 students, 9 schools from central part of state), the students in 2018 (4 schools scattered across state) reported wearing seatbelts “always” (n = 69% vs 39%; p < 0.001); “never texting while driving” (78% vs 33%; p < 0.001); and “never drinking and driving” (97% vs 88%; p < 0.001). No significant difference in rates of students having taken a driving education class nor driving over speed limit were reported.

Conclusion

Results are encouraging that participants in 2018 report more use of seatbelts, less texting while driving, less drinking while driving and lower numbers of being in MVC than in 2009. However, rates of high-risk driving behaviors are still concerning.
Effect of lock boxes and education on safe storage of medications
Authors: Webb Alicia C. , Nichols Michele H. , Shah Nipam , Monroe Kathy W.
Published: June 2020

Background

Safe medication storage is a proven barrier to ingestions in the pediatric population, but caregivers are often unaware of the importance of safe storage practices or do not have a safe place to store medications. Caregivers may also not be fully aware that the patterns of opioid use and misuse have recently reached crisis levels. The objectives of this study were to define medication storage practices and knowledge of the opioid crisis of participants and to assess the effectiveness of an emergency department intervention on safe medication storage.

Methods

This was a prospective interventional study of caregivers in an urban pediatric emergency department (ED) on safe medication storage and the opioid crisis. Questions assessed the caregivers’ current perceptions and practices related to medication storage and disposal, and opioid crisis awareness. The intervention included verbal instruction about recommended safe storage methods and the opioid crisis, provision of a medication safety handout, and distribution of a medication lock box. A follow-up phone survey conducted 2 weeks later asked participants about use of and satisfaction with the lock box. Frequencies of safe storage behaviors were calculated, and the chi-square statistic was used to compare storage behavior after the intervention.

Results

Fifty caregivers of 112 children were enrolled. Only 4% reported they currently stored medications in a locked or latched place. Thirty-eight percent reported their main barrier to storing medications safely was that they did not have a locked or latched storage location. Fifty percent were unaware of the opioid crisis. Ninety-two percent reported they would use a lock box if given one. Twenty-eight participants (56%) responded to the follow-up phone call survey 2 weeks later. At follow up 90% (25/28) reported they placed their medications within the provided lock box (p < 0.00001). Ninety-two percent reported being “very satisfied” with the lock box and how it works.

Conclusions

Despite widespread reporting on this issue, many caregivers remain unaware of safe medication storage practices and the opioid crisis. Providing medication lock boxes removes a commonly reported barrier to safely storing medications and improved reported practices.
Grade 3 well-differentiated neuroendocrine tumor of the rectum: a case report
Authors: Ito Misato , Hirano Yasumitsu , Isii Toshimasa , Kondo Hiroka , Wang Liming , Asari Masahiro , Obara Nao , Yamaguchi Shigeki
Published: June 2020

Background

The 2019 revised World Health Organization (WHO) classification of tumors of endocrine organs classifies grade 3 gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN G3) into well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC G3). There are few reported cases of NET G3 occurring in the rectum.

Case presentation

A 71-year-old man complained of bright red blood in his stool. Total colonoscopy revealed a mass in the lower rectum. Pathologic examination yielded a diagnosis of group 1. Computed tomography revealed swollen paraintestinal lymph nodes and multiple liver metastases. We performed laparoscopic abdominoperineal resection not only to avoid the unbearable symptoms caused by tumor growth but to make a pathological diagnosis. The tumor measured 3.5 × 2.8 cm, and the pathological diagnosis was stage IV neuroendocrine carcinoma. He underwent chemotherapy with irinotecan plus cisplatin, followed by carboplatin plus etopside, but his disease did not respond to either regimen. Twenty-seven months after surgery, he died of his disease. Upon re-examination of the surgical specimen, the tumor was consistent with the 2019 WHO classification of NET G3.6

Conclusion

A definite diagnosis of NET G3 or NEC G3 must be made to determine the appropriate treatment strategy for patients with GEP-NEN G3. Further case reports and case series are needed to establish the optimal therapy.
Central hepatectomy for hepatocellular carcinoma in a patient with anti-Gerbich antibody
Authors: Komokata Teruo , Inoue Maki , Aryal Bibek , Yasumura Hiroto , Mori Chinami , Nomoto Mituharu , Kaieda Mamoru , Hanada Shuichi
Published: June 2020

Background

Anti-Gerbich (Ge) alloantibody against high-frequency erythrocyte antigen is extremely rare. Owing to incomplete evidence regarding the degree and severity of adverse events induced by hemolytic transfusion reactions, the transfusion management often remains cumbersome in these patients. We report an anti-Ge alloantibody positive patient with hepatocellular carcinoma (HCC) who underwent central hepatectomy (CH) without the need for an allogeneic blood transfusion.

Case presentation

A 76-year-old Japanese woman was diagnosed with HCC measuring 9.5 × 8.0 cm in segments 4, 5, and 8 of the liver. This patient with anti-Ge alloantibody had a history of two pregnancies without transfusion. CH was planned, and based on the suggestion from the multidisciplinary team meeting, preoperative autologous donation (PAD) and acute normovolemic hemodilution (ANH) were performed. CH was successfully performed by using CUSA and Thunderbeat® with Pringle maneuver and infra-hepatic inferior vena cava clamping without perioperative need for an allogeneic blood transfusion. She has been alive without recurrence after a follow-up period of 45 months.

Conclusion

To our knowledge, this is the first case report of hepatectomy in a patient with anti-Ge alloantibody. A multidisciplinary team approach, PAD and ANH, and bloodless liver surgical techniques appear to be useful for major hepatectomy in patients with extremely rare blood type.
Methanol extract of Spathodea campanulata P. (Beauv.) leaves demonstrate sedative and anxiolytic like actions on swiss albino mice
Authors: Begum Anawara , Biswas Purobee , Shahed-Al-Mahmud Md.
Published: June 2020

Background

Spathodea campanulata P. Beauv. (Bignoniaceae) is a very common plant in Bangladesh which is locally called “Rudrapalash”. In Nigeria leaves extract of S. campanulata has a reputation of being used as an anticonvulsant. In this connection, the aim of this study was to investigate other neuropharmacological effects like sedative and anxiolytic activities of methanol extract of S. campanulata (MESC) leaves in different mice tests.

Methods

To assay sedative activity mice were subjected to open field and hole-cross test, whereas anxiolytic activity was checked by the elevated-plus maze, light-dark box, and hole-board test. For each test, mice were divided into control group (deionized water, 0.1 ml/mouse, p.o.), standard group (diazepam, 1 mg/kg, i.p) and three test groups (200, 400 and 600 mg/kg MESC, p.o.). The acute toxicity test and phytochemical screening of MESC were performed before the pharmacological study.

Results

The result demonstrated strong sedative and anxiolytic activity of MESC in a dose-dependent manner. All doses of MESC (200, 400 & 600 mg/kg) reduced the number of (square & hole) crossed by mice in both open field and hole cross tests (p < 0.001). On the other hand, in elevated plus-maze and light-dark box test mice opted to stay more in open arms and light box instead of close arms and dark box (p < 0.001). In hole-board test MESC (200, 400 & 600 mg/kg) elevated the number of head dipping (p < 0.001) dose-dependently. Phytochemical investigation indicated the presence of alkaloid, saponin, glycoside, carbohydrate, flavonoid, and tannin in MESC.

Conclusion

The experimental results explicit that S. campanulata leaves possess sedative and anxiolytic activities, hence suggest further chemical investigation to identify specific phytoconstituents responsible for sedative and anxiolytic effects.
Prevalence and associated risk factors of self-medication among patients attending El-Mahsama family practice center, Ismailia, Egypt
Authors: Zeid Wael , Hamed Madeha , Mansour Nadia , Diab Rokaya
Published: June 2020

Background

Self-medication is defined as taking medications without the physician’s prescription. It is a worldwide public health problem, especially in countries with limited resources. Although self-medication can reduce waiting time and save money, it may carry some potential risks, e.g., antibiotic resistance or inappropriate management with subsequent complication. A limited number of self-medication studies have been conducted in Egypt.

Objectives

To determine the prevalence of self-medication practices and to identify the factors associated with self-medication

Methods

A cross-sectional study was conducted on 160 patients. The sample was randomly selected from those who attended the El-Mahsama family practice center, Ismailia, Egypt, from November 2018 to February 2019. The center is affiliated to the Suez Canal University and provides preventive and curative services to a rural community. The participants were interviewed using a semi-structured questionnaire including sociodemographic scale and self-medication knowledge and behavior. Data was analyzed using descriptive and analytic statistical methods.

Results

Frequency of self-medication among the study sample has reached 96%. More than half of the participants (53.6%) reported that the first reason behind using self-medication was cost saving. Meanwhile, the most prevalent conditions that make them use these medications by themselves were headaches (17%), aches and pain (other than headache) (39.2%), and fevers (11.8%). The most frequent self-administered drugs were analgesics (59.5%) and antibiotics (23.5%).

Conclusion

Prevalence of self-medication is high among all socioeconomic levels of patients attending the El-Mahsama family practice center, which serves a rural community in Ismailia governorate, Egypt.
Expert consensus on clinical applications of high-frequency oscillations in epilepsy
Authors: Wang Yuping , Zhou Dong , Yang Xiaofeng , Xu Xin , Ren Liankun , Yu Tao , Zhou Wenjing , Shao Xiaoqiu , Yang Zhixian , Wang Shuang , Cao Dezhi , Liu Chunyan , Kwan Shang Yeong , Xiang Jing
Published: June 2020

Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations (HFOs, > 80 Hz) and the epileptogenic zone, suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis. This consensus includes the definition and standard detection techniques of HFOs, the localizing value of pathological HFOs for epileptic foci, and different ways to distinguish physiological from epileptic HFOs. The latest clinical applications of HFOs in epilepsy and the related findings are also discussed. HFOs will advance our understanding of the pathophysiology of epilepsy.
Pore structure and controlling factors of dolomite-bearing high-salinity shale reservoir in Qianjiang Formation, Jianghan Basin, China
Authors: Zhou Tong , Su Jianzheng , Fan Shichao , Li Zhaofeng , Liu Xiaoxue , Tang Xianglu
Published: June 2020

High-salinity shale is a unique and promising shale-oil reservoir in continental basins. We have collected representative samples from different lithologies from wells in the Qianjiang Depression to test the pore structure and basic character from prospective high-salinity oil-bearing shales. We conducted field emission scanning electron microscopy and X-ray diffraction analyses to study the high-salinity shale pore morphology and composition, respectively. We used mercury injection capillary pressure to understand the high-salinity shale macropore distribution, and we used low-pressure nitrogen (N2) adsorption to study the mesopore distribution. The results show that the high-salinity shale-oil reservoir mainly is composed of carbonate (dolomite and calcite), clay, and saline minerals (anhydrite, glauberite, and halite). Many intergranular pores were developed in the high-salinity shale. The mesopores and macropores both were developed well in argillaceous dolomite. The average pore volume of macropores is 0.0588 ml/g, which accounts for approximately 59% of the total pore volume. Therefore, in the high-salinity shale-oil reservoirs that we tested, macropores were more important than other pores. The symbiosis of dolomite and calcite improved the porosity of the high-salinity shale-oil reservoir, and the salt minerals increased the pore complexity.
A method to compensate for migration stretch to improve the resolution of amplitude variation with offset, S-impedance (ZS), and density (ρ)
Authors: Patel Swetal , Oyebanji Francis , Marfurt Kurt J.
Published: June 2020

Because of their improved leverage against ground roll and multiples, as well as the ability to estimate azimuthal anisotropy, wide-azimuth 3D seismic surveys routinely now are acquired over most resource plays. For a relatively shallow target, most of these surveys can be considered to be long offset as well, containing incident angles up to 45°. Unfortunately, effective use of the far-offset data often is compromised by noise and normal moveout (NMO) (or, more accurately, prestack migration) stretch. The conventional NMO correction is well-known to decrease the frequency content and distort the seismic wavelet at far offsets, sometimes giving rise to tuning effects. Most quantitative interpreters work with prestack migrated gathers rather than unmigrated NMO-corrected gathers. However, prestack migration of flat reflectors suffers from the same limitation called migration stretch. Migration stretch leads to lower S-impedance ([Formula: see text]) and density ([Formula: see text]) resolution estimated from inversion, misclassification of amplitude variation with offset (AVO) types, and infidelity in amplitude variation with azimuth (AVAZ) inversion results. We have developed a matching pursuit algorithm commonly used in spectral decomposition to correct the migration stretch by scaling the stretched wavelets using a wavelet compensation factor. The method is based on hyperbolic moveout approximation. The corrected gathers show increased resolution and higher fidelity amplitudes at the far offsets leading to improvement in AVO classification. Correction for migration stretch rather than conventional “stretch-mute” corrections provides three advantages: (1) preservation of far angles required for accurate [Formula: see text] inversion, (2) improvement in the vertical resolution of [Formula: see text] and [Formula: see text] volumes, and (3) preservation of far angles that provide greater leverage against multiples. We apply our workflow to data acquired in the Fort Worth Basin and retain incident angles up to 42° at the Barnett Shale target. Comparing [Formula: see text], [Formula: see text], and [Formula: see text] of the original gather and migration stretch-compensated data, we find an insignificant improvement in [Formula: see text], but a moderate to significant improvement in resolution of [Formula: see text] and [Formula: see text]. The method is valid for reservoirs that exhibit a dip of no more than 2°. Consistent improvement is observed in resolving thick beds, but the method might introduce amplitude anomalies at far offsets for tuning beds.
Seismic response to paleo-sand dunes in the Nugget Sandstone Formation, southwestern Wyoming
Authors: Agrawal Dhruv , Lujan Brady , Verma Sumit , Bhattacharya Shuvajit , Mallick Subhashis
Published: June 2020

We have analyzed a 3D seismic survey acquired for a carbon sequestration project on top of the Moxa Arch in southwestern Wyoming. We observed a zone of discontinuous reflectors on vertical slices of seismic amplitude volume, whereas, the northwest–southeast lineations were observed on the time slices. We performed a seismic to well tie that suggested that the lineations occur within the Nugget Sandstone. The Nugget Sandstone is an eolian sandstone deposit of Early Jurassic age, deposited as a subtropical dune field, and equivalent to the Navajo Sandstone of southwestern Utah. Petrophysical analysis indicates that the Nugget Sandstone is dominated by clean sandstone (70%–80%), whereas evaporites, including halite and anhydrite, are present in certain zones. Previous outcrop studies on the Navajo Sandstone indicate the wind direction to be predominantly northeast–southwest. Seismic attributes, including coherence and curvature, displayed on stratal slices within the Nugget Sandstone interval indicate the presence of lineations in the northwest–southeast direction with irregular spacing. These lineations are approximately perpendicular to the inferred dominant wind direction. We computed the dominant wind direction from the average azimuth of the lineations as seen on the curvature attribute in the Nugget Sandstone interval.

Geological feature: Eolian sand dunes with interdunal evaporites Seismic appearance: Parallel lineations with irregular spacing on seismic attribute horizon slices Alternative interpretations: Canyons at continental slopes; slope failures Features with a similar appearance: Marine bars; contourites Formation: The Nugget Sandstone — equivalent to the Navajo Sandstone Age: Early Jurassic Location: Moxa Arch, Wyoming Seismic data: Obtained by the University of Wyoming with U.S. DOE funding Contributors: Dhruv Agrawal, Brady Lujan, Sumit Verma, Shuvajit Bhattacharya, and Subhashis Mallick Analysis tools: Coherence and curvature attributes; seismic inversion; petrophysical inversion
Reliability analysis of seismic attribute in the detection of fault-karst
Authors: Ding Yan , Du Qizhen , Fu Liyun , Jian Shikai
Published: June 2020

In the Tarim Basin, various irregular fractured-vuggy reservoirs have developed along with the main faults. These reservoirs are geologically defined as carbonate fault karst. In the past few years, seismic attributes have been widely used for the identification and evaluation of fault karst. However, there has been less reliability analysis regarding their usage. Imaging using the theoretical fault-karst velocity model can reflect the shapes and distributions of fractures and vugs, whereas imaging using the background velocity can simulate seismic data in real cases. We have adopted an approach based on typical fault-karst theoretical forward modeling to evaluate the reliability of seismic attributes in practical applications. First, we extract various attributes from the images using the theoretical velocity and the background velocity using similarity estimation between them to optimize the sensitive attributes. The analysis result indicates that the instantaneous phase, variance, amplitude gradient, coherence, and texture entropy are more suitable to characterize the anomalies of fractures and vugs with prediction accuracy of 71.7%. Because fracture orientation and density are the key parameters for quantifying the differences between the two images, taking coherence as an example, we extract the fracture traces through circular scanlines and circular windows based on the optimized attributes. The coincidence rate between the predicted fracture density and the known model reaches 83%, and that between the predicted fracture orientation and the known model is greater than 95%. With this remarkable coincidence, we can conclude that optimized seismic attributes are reliable for characterizing fractured-vuggy reservoirs.
Seismic attributes and analogs to characterize a large fold in the Taranaki Basin
Authors: La Marca Molina Karelia , Bedle Heather , Tellez Jerson
Published: June 2020

The Taranaki Basin lies in the western portion of New Zealand, onshore and offshore. It is a Cretaceous rift basin that is filled with up to approximately 10 km thick deposits from marine to deepwater depositional environments from the Cretaceous (approximately 93 ma) to the Neogene (approximately 15 ma). This basin underwent important tectonic events that resulted in large-scale features such as faults and folds and the deposition of turbidites such as channels and channel belts. These features easily are recognizable in seismic data. When analyzing the offshore 3D Pipeline data set, we recognized a peculiar fault-like feature with large-scale dimensions (approximately 15 km long and approximately 1 km wide) within the sequence. The alignment was perpendicular to the direction of deposition in the basin (southeast–northwest) as identified by previous studies and subparallel to the main structures in the area (southwest–northeast). We interpreted the seismic character of the funny-looking thing (FLT) likely as (1) a fault, (2) a fold, or (3) a large channel belt within the basin. We use seismic attributes such as coherence (Sobel filter), dip, cosine of phase, and curvature to characterize this feature geomorphologically. The geologic background of the area and analog settings aided in understanding and distinguishing the nature of this large structure. Monocline examples in seismic data are rare to find, and we want to show how to avoid misinterpretations.

Geological feature: Fault-bend fold or large-amplitude fold (possibly monocline) Seismic appearance: Large, discontinuous, high-variance feature Alternative interpretations: Fault, fold Features with a similar appearance: Fault, fold, wide straight channel belt (time or horizon slice) Formation: Rift sequence of the Taranaki Basin Age: Eocene Location: Taranaki Basin, Western offshore New Zealand Seismic data: Provided by New Zealand Petroleum and Minerals Contributors: Karelia La Marca, Heather Bedle, Jerson Tellez; School of Geosciences; University of Oklahoma, Norman, OK, USA Analysis tool: 3D reflection seismic, geometric seismic attributes
Systematic Review of Modern Case Series of Squamous Cell Cancer Arising in a Chronic Ulcer (Marjolin's Ulcer) of the Skin
Authors: Abdi Mohamed A. , Yan Michael , Hanna Timothy P.
Published: June 2020

PURPOSE

Marjolin's ulcer is an aggressive cutaneous malignancy that arises in chronic nonhealing wounds. A review of modern series describing Marjolin's ulcer would be helpful in defining optimal management strategies and expected outcomes.

METHODS

A systematic review was performed on October 18, 2018, by querying Medline and EMBASE. Key inclusion criteria were as follows: human studies, English language, published in 2000 or later, > 10 patients, and at least 80% of the patients having squamous cell carcinoma (SCC) histology.

RESULTS

There were 599 patients in 14 case series from 10 countries; 82% of patients were from low-income and middle-income countries, and 48% were women. Overall, 65% of the ulcers were preceded by burns. Mean latency ranged from 11 years to 41 years (median, 28 years). Lower extremities were the most common site (62%). Differentiation was reported as well differentiated (64%), moderately differentiated (27%), or poorly differentiated (9%). Almost one third of cases were clinically node positive, though only 7% of all cases (24 of 334) were confirmed to be pathologically involved. Distant metastasis rates were reported in only 7 series, with median rate of 5% (range, 0%-27%). The main treatment modality was surgical excision (71%), followed by amputation (24%), primary radiotherapy (2%), and chemotherapy (< 1%). Outcomes data varied in content and quality. Mortality rates were 12%, 24%, and 37% in the three series reporting between 2 and 3 years of follow-up.

CONCLUSION

Marjolin's ulcer with SCC histology is an aggressive cancer with a notable potential for lymph node metastasis and distant metastasis. Comprehensive staging is recommended, with management optimally having a multidisciplinary context. Low- and middle-income countries are overrepresented in reports of Marjolin’s ulcer, and there may be opportunities for prevention and early detection.
Improved Risk Prediction Calculator for Sentinel Node Positivity in Patients With Melanoma: The Melanoma Institute Australia Nomogram
Authors: Lo Serigne N. , Ma Jiawen , Scolyer Richard A. , Haydu Lauren E. , Stretch Jonathan R. , Saw Robyn P. M. , Nieweg Omgo E. , Shannon Kerwin F. , Spillane Andrew J. , Ch’ng Sydney , Mann Graham J. , Gershenwald Jeffrey E. , Thompson John F. , Varey Alexander H. R.
Published: June 2020

PURPOSE

For patients with primary cutaneous melanoma, the risk of sentinel node (SN) metastasis varies according to several clinicopathologic parameters. Patient selection for SN biopsy can be assisted by National Comprehensive Cancer Network (NCCN) and ASCO/Society of Surgical Oncology (SSO) guidelines and the Memorial Sloan Kettering Cancer Center (MSKCC) online nomogram. We sought to develop an improved online risk calculator using alternative clinicopathologic parameters to more accurately predict SN positivity.

PATIENTS AND METHODS

Data from 3,477 patients with melanoma who underwent SN biopsy at Melanoma Institute Australia (MIA) were analyzed. A new nomogram was developed by replacing body site and Clark level from the MSKCC model with mitotic rate, melanoma subtype, and lymphovascular invasion. The predictive performance of the new nomogram was externally validated using data from The University of Texas MD Anderson Cancer Center (n = 3,496).

RESULTS

The MSKCC model receiver operating characteristic curve had a predictive accuracy of 67.7% (95% CI, 65.3% to 70.0%). The MIA model had a predictive accuracy of 73.9% (95% CI, 71.9% to 75.9%), a 9.2% increase in accuracy over the MSKCC model ( P < .001). Among the 2,748 SN-negative patients, SN biopsy would not have been offered to 22.1%, 13.4%, and 12.4% based on the MIA model, the MSKCC model, and NCCN or ASCO/SSO criteria, respectively. External validation generated a C-statistic of 75.0% (95% CI, 73.2% to 76.7%).

CONCLUSION

A robust nomogram was developed that more accurately estimates the risk of SN positivity in patients with melanoma than currently available methods. The model only requires the input of 6 widely available clinicopathologic parameters. Importantly, the number of patients undergoing unnecessary SN biopsy would be significantly reduced compared with use of the MSKCC nomogram or the NCCN or ASCO/SSO guidelines, without losing sensitivity. An online calculator is available at www.melanomarisk.org.au .
Developing laboratory capacity for Good Laboratory Practice certification: lessons from a Tanzanian insecticide testing facility
Authors: Begg Sara , Wright Alexandra , Small Graham , Mosha Franklin , Kirby Matthew , Snetselaar Janneke , Aziz Salum , Bharmal Jameel , Dacombe Russell , Bates Imelda
Published: June 2020

Background:With increasing insecticide resistance in malaria-endemic countries there is an urgent need for safe and effective novel vector control products. To improve the capacity of facilities that test insecticides in sub-Saharan Africa, a programme is supporting seven facilities towards Good Laboratory Practice (GLP) certification, the globally recognized standard for quality management system (QMS) for the conduct of non-clinical and environmental studies. The World Health Organization (WHO) GLP Handbook provides guidance on a stepwise approach to implement a GLP compliant QMS. This study assesses auditor GLP checklists and timings outlined in the WHO GLP Handbook in the real-life context of a Tanzanian insecticide-testing facility, evaluating their implementation in this context.

Methods and Principle Findings:We conducted document review and semi-structured interviews with staff at all levels of the test facility to explore factors that influenced progress towards GLP certification. We found that while auditor GLP checklists underemphasised computer systems, they were otherwise broadly applicable. Factors that delayed time to completion of GLP certification included the need for extensive infrastructure improvements, the availability of regional expertise related to GLP, the capacity of national and regional external systems and services to meet GLP compliance requirements, and training development required for Standard Operating Procedure implementation.

Conclusion:The standards required for full GLP compliance are rigorous, with an expected completion timeline to implementation of 24 months. This study shows that in low and middle-income countries this timeline may be unrealistic due to challenges related to infrastructure development and lack of regional capacity and expertise. We recommend a comprehensive gap analysis when starting a project, including these areas which are beyond those recommended by the WHO GLP Handbook. These challenges can be successfully overcome and the experience in Tanzania provides key lessons for other facilities seeking GLP certification or the development of similar QMS.
A multi centre randomized open label trial of chloroquine for the treatment of adults with SARS-CoV-2 infection in Vietnam
Authors: Kestelyn Evelyne , Dung Nguyen Thi Phuong , Lam Minh Yen , Hung Le Manh , Quan Nguyen Minh , Dung Nguyen Thanh , Minh Ngo Ngoc Quang , Xuan Tran Chanh , Phong Nguyen Thanh , Ninh Thi Thanh Van , Donovan Joseph , Tu Tran Nguyen Hoang , Nhat Le Thanh Hoang , Truong Nguyen Thanh , Man Dinh Nguyen Huy , Thao Huynh Phuong , Ngoc Nghiêm My , Lam Vo Thanh , Phat Huynh Hong , Phuong Phan Minh , Geskus Ronald B. , Ha Vo Thi Nhi , Quang Nguyen Ngo , Tran Tinh Hien , Tan Le Van , Thwaites Guy E. , Day Jeremy N. , Chau Nguyen Van Vinh ,   OUCRU COVID-19 Research Group
Published: June 2020

Background: COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. There is currently no vaccine to prevent COVID-19 or therapeutic agent to treat COVID-19. This clinical trial is designed to evaluate chloroquine as a potential therapeutic for the treatment of hospitalised people with COVID-19. We hypothesise that chloroquine slows viral replication in patients with COVID-19, attenuating the infection, and resulting in more rapid decline of viral load in throat/nose swabs. This viral attenuation should be associated with improved patient outcomes.

Method: The study will start with a 10-patient prospective observational pilot study following the same entry and exclusion criteria as for the randomized trial and undergoing the same procedures. The main study is an open label, randomised, controlled trial with two parallel arms of standard of care (control arm) versus standard of care with 10 days of chloroquine (intervention arm) with a loading dose over the first 24 hours, followed by 300mg base orally once daily for nine days. The study will recruit patients in three sites in Ho Chi Minh City, Vietnam: the Hospital for Tropical Diseases, the Cu Chi Field Hospital, and the Can Gio COVID hospital. The primary endpoint is the time to viral clearance from throat/nose swab, defined as the time following randomization until the midpoint between the last positive and the first of the negative throat/nose swabs. Viral presence will be determined using RT-PCR to detect SARS-CoV-2 RNA.

Discussion: The results of the study will add to the evidence-based guidelines for management of COVID-19. Given the enormous experience of its use in malaria chemoprophylaxis, excellent safety and tolerability profile, and its very low cost, if proved effective then chloroquine would be a readily deployable and affordable treatment for patients with COVID-19.

Trial registration: Clinicaltrials.gov NCT04328493 31/03/2020
Precision in a Seller’s Market: Round Asking Prices Lead to Higher Counteroffers and Selling Prices
Authors: Leib Margarita , Köbis Nils C. , Francke Marc , Shalvi Shaul , Roskes Marieke
Published: June 2020

Precise, compared with round, asking prices lead to counteroffers and final agreements that are closer to the asking price. Consequently, popular advice for sellers is to set precise asking prices. We propose that the advice is useful, but only in a buyer’s market, in which buyers counter below the asking price. In a seller’s market, in which buyers counter above the asking price, sellers who wish to receive high counteroffers and sell for high prices should set round asking prices. A preregistered study (n = 1,809) shows that, compared with round asking prices, precise prices lead to higher counteroffers in a buyer’s market but to lower counteroffers in a seller’s market. The effect is driven by buyers’ use of a finer-grained pricing scale when countering precise asking prices. An analysis of transactions (n = 8,278) from Amsterdam’s 2017 real estate market, in which 70% of the properties were sold above the asking price, corroborates the experimental findings. Results show that increasing the roundness of the asking price by one decimal, for instance, from precise to the thousands to precise to the tens of thousands, was associated with an increase of 0.6% in the selling price, equivalent to €2,099 on average.

This paper was accepted by Yuval Rottenstreich, decision analysis.
Antiplatelet therapy for transient ischaemic attack and minor ischaemic stroke
Authors: Kalladka Dheeraj , Rounis Elisabeth
Published: June 2020

Transient ischaemic attacks carry an increased risk of large ischaemic stroke in the 90 days after an event. Patients need to be seen within 24 hours in a dedicated clinic to start secondary prevention. This editorial reviews evidence for consideration of early dual antiplatelet therapy after a transient ischaemic attack.
Treatment of 52 patients with a self-adhesive siliconised superabsorbent dressing: a multicentre observational study
Authors: Barrett Simon , Rippon Mark , Rogers Alan A.
Published: June 2020

Objective:

To provide ‘in use’ clinical data to support exudate management in patients with moderately to highly exuding wounds with bordered superabsorbent wound dressing with a silicone adhesive interface.

Method:

This study was an open-labelled non-comparative study. Patients included in the study were selected by the clinical investigator(s) according to whether the patient required a dressing for the management of moderately to highly exuding wounds.

Results:

The primary aim of this study was to evaluate the clinical objective in relation to exudate handling (moderate to high) with a superabsorbent silicone border dressing (Zetuvit Plus Silicone Border; SAP silicone border dressing; designated RespoSorb Silicone Border in some countries). The SAP border dressing had met the clinical objectives relating to exudate management, affirmed by the health professionals with a yes response in 94% of cases. Additionally, the health professionals rated the handling of exudate as excellent/good (78%) and most (80%) reported that they would use the SAP silicone border dressing again. Allied to this was the fact that the SAP silicone border dressing improved the wound edge and periwound skin conditions (29% and 36% of patients, respectively). Regarding dressing retention, the SAP silicone border dressing retained its position in 72% of patients. For wear time, the largest proportion of dressing changes, both pre-study and during the evaluation period, was every third day (45% and 44%, respectively). But there was a shift to extended wear time with use of the SAP silicone border dressing with 72% of patients' dressing changes being every third day or longer.

Conclusion:

The SAP silicone border dressing was successful in managing wound exudate in moderately to highly exuding wounds and consequently this had a beneficial impact on the wound edge and periwound skin. Overall, there was a positive effect on wound bed preparation and in turn the healing response was progressive. This study has shown that the SAP silicone border dressing successfully controlled exudate and provided positive benefits when used in the treatment of patients with moderately to highly exuding wounds.
Desempenho Social Corporativo em Instituições de Ensino Superior: a Visão dos Gestores Sobre os Stakeholders
Authors: Langrafe Taiguara de Freitas , Fischmann Adalberto Américo , Boaventura João Maurício Gama , Meireles Fernanda Rosalina da Silva
Published: June 2020

O objetivo deste trabalho é analisar a importância relativa dos stakeholders das Instituições de Ensino Superior (IES) para o Desempenho Social Corporativo, segundo a percepção dos Gestores das IES brasileiras. Apresenta como problema de pesquisa o gap sobre o cálculo do CSP, que não é claro, em particular quanto à importância relativa de cada stakeholder. Nota-se a ausência de pesquisas delimitadas em um setor e contexto específicos. Os dados foram obtidos através de uma survey, com questionário validado por especialistas, enviado por e-mail para 2.391 IES brasileiras, obtendo 88 respostas completas. É possível identificar diferenças na importância relativa dos stakeholders de acordo com os diferentes aspectos pesquisados – no geral, a maior importância relativa para Corpo Docente, Corpo Discente e Corpo Técnico-Administrativo, e menor para Fornecedores. O trabalho permite identificar heterogeneidade de importância dos stakeholders de acordo com a natureza da IES (Pública ou Privada), além de trazer dados empíricos inéditos sobre a relevância dos stakeholders no contexto de IES brasileiras. Evidencia-se que os gestores de IES Públicas têm uma visão mais superficial de seus stakeholders, pouco diferenciando-os entre si. Por sua vez, os gestores de IES Privadas apresentam uma visão mais detalhada e rica dos múltiplos stakeholders, classificando-os em diferentes níveis de importância.
Publishing in co-authorship: A comparison of the motivations between more and less prolific Management scholars in Brazil
Authors: Ferreira Manuel Portugal , Falaster Christian Daniel , Pinto Cláudia Sofia Frias , Canela Renata
Published: June 2020

In this study, we investigate what more and less prolific scholars – that publish more or less scientific articles – search for in their co-authorship ties. Specifically, we seek to understand if and how there are differences in the motivations presiding to co-authorship between more and less prolific researchers. Research on co-authorship is of interest to the academia, since the majority of the articles are published in co-authorship and co-authorships may have an important impact in the scholars’ career. We have collected survey data with 171 Brazilian management faculty, about their motivations, pressures, and choices for co-authorship. We identify significant differences on the perceived pressures to publish, source of pressure, motivations to work in co-authorship and the contributions warranting co-authorship across more and less prolific researchers. We contribute to the debate on the development of scholars and the formation of co-authorship ties, suggesting that co-authorship may be strategically managed and evolving along the professional path of the researchers, and leaving the possibility that scholars’ networks of co-authorship evolve strategically as they seek different goals.
Validation of uniformity-optimized irradiance distribution on a well-plate platform from a light-emitting-diode array
Authors: Homsirikamol Chaiyarerk , Suvanasuthi Saroj , Viravaidya-Pasuwat Kwanchanok
Published: June 2020

The computational optimization of irradiance distribution uniformity has been conducted in several studies to obtain the evenness of photoresponses on an irradiated surface using light-emitting-diode (LED) arrays. However, there has been little discussion on the precision of predictive simulations. This study aims to validate the simulated irradiance predicted by a mathematical model on the working area of a six-well plate and investigate the spatial consistency of the photobleaching of methylene blue and IR-820 photosensitizers on the bottom of the different wells illuminated by using the local-search-optimized LED configurations. The validation signified the negative deviation of both the measured irradiance and irradiance uniformity as compared to the simulated data. Despite the coefficients of variation observed as low as 1.9% and 7.4% for red-light and infrared irradiance, respectively, the photobleaching responses were found to be spatially diverse. The implications of this study are opportunities for further enhancements to the predictability of the simulations for the design of prospective illumination setups.
Influence of seed layers on optical properties of aluminum in the UV range
Authors: Stempfhuber Sven , Felde Nadja , Schwinde Stefan , Trost Marcus , Schenk Paul , Schröder Sven , Tünnermann Andreas
Published: June 2020

The potential of titanium and copper seed layers to enhance the optical properties of aluminum films for ultra-violet (UV) applications is analyzed. The seed layers significantly influence the initial layer growth of aluminum films. For the titanium-seeded aluminum, a surface roughness of 0.34 nm was observed. UV spectral reflectance measurements showed an average higher reflectivity of 4.8% for wavelengths from 120 nm to 200 nm for the aluminum film grown on the titanium seed layer. Furthermore, the titanium-seeded aluminum coatings were stable at an elevated temperature of 225°C and showed no increase in surface roughness or pinholes.
Analyzing and generating multimode optical fields using self-configuring networks
Authors: Miller David A. B.
Published: June 2020

Working with finite numbers of modes to describe, generate, and detect optical fields can be both mathematically economical and physically useful. Such a modal basis can map directly to various applications in communications, sensing, and processing. But, we need a way to generate and analyze such fields, including measurement and control of both the relative amplitudes and phases of the modal components. Ideally such an analysis scheme would operate directly on the field, without needing a separate, mutually coherent reference beam. Here, we show first how to measure all those relative amplitudes and phases automatically and simultaneously. The method repurposes a self-configuring network of2×2blocks, such as integrated Mach–Zehnder interferometers, that can automatically align itself to the optical field by a sequence of simple one-parameter power minimizations when network elements, such as phase shifters, are adjusted. The optical field is then directly deduced from the resulting settings of those elements. We show how the entire network can be calibrated for such measurements, automatically and with just two light beams. Then, using the same calibration and running the mesh backwards, we can also controllably generate an arbitrary multimode field. Explicit algorithms and formulas are given for operating this system.
Enhancement of the steepness measurement of a film thickness edge using wavelet transforms with fringe thinning
Authors: Abdelsalam Ibrahim Dahi Ghareab
Published: June 2020

Demodulation of steep abrupt heights is a challenging task in interferometry because scattering from the steep region is typically weak. In this paper, we enhance the steepness measurement of steep abrupt heights in a phase-contrast image by applying a fringe thinning process before demodulation with the Morlet wavelet transforms. We demonstrate the proposed method with two steep abrupt heights of 200 µm and 30 mm. Use of this method improves the steepness substantially as compared with conventional measurements.