bluuebunny/crossref_metadata_2025 huggingface dataset:
Capacity investment decisions of energy storage power stations supporting wind power projects
Authors: Song Mingzhen , Kong Lingcheng , Xie Jiaping
Published: September 2023

Purpose

Rapidly increasing the proportion of installed wind power capacity with zero carbon emission characteristics will help adjust the energy structure and support the realization of carbon neutrality targets. The intermittency of wind resources and fluctuations in electricity demand has exacerbated the contradiction between power supply and demand. The time-of-use pricing and supply-side allocation of energy storage power stations will help “peak shaving and valley filling” and reduce the gap between power supply and demand. To this end, this paper constructs a decision-making model for the capacity investment of energy storage power stations under time-of-use pricing, which is intended to provide a reference for scientific decision-making on electricity prices and energy storage power station capacity.

Design/methodology/approach

Based on the research framework of time-of-use pricing, this paper constructs a profit-maximizing electricity price and capacity investment decision model of energy storage power station for flat pricing and time-of-use pricing respectively. In the process, this study considers the dual uncertain scenarios of intermittency of wind resources and random fluctuations in power demand.

Findings

(1) Investment in energy storage power stations is the optimal decision. Time-of-use pricing will reduce the optimal capacity of the energy storage power station. (2) The optimal capacity of the energy storage power station and optimal electricity price are related to factors such as the intermittency of wind resources, the unit investment cost, the price sensitivities of the demand, the proportion of time-of-use pricing and the thermal power price. (3) The carbon emission level is affected by the intermittency of wind resources, price sensitivities of the demand and the proportion of time-of-use pricing. Incentive policies can always reduce carbon emission levels.

Originality/value

This paper creatively introduced the research framework of time-of-use pricing into the capacity decision-making of energy storage power stations, and considering the influence of wind power intermittentness and power demand fluctuations, constructed the capacity investment decision model of energy storage power stations under different pricing methods, and compared the impact of pricing methods on optimal energy storage power station capacity and carbon emissions.

Highlights

Electricity pricing and capacity of energy storage power stations in an uncertain electricity market.

Investment strategy of energy storage power stations on the supply side of wind power generators.

Impact of pricing method on the investment decisions of energy storage power stations.

Impact of pricing method, energy storage investment and incentive policies on carbon emissions.

A two-stage wind power supply chain including energy storage power stations.
The impact of memorable tourism experiences on customer-based destination brand equity: the mediating role of destination attachment and overall satisfaction
Authors: Guleria Ayush , Joshi Richa , Adil Mohd
Published: September 2023

Purpose

Utilising the stimulus-organism-response (S-O-R) theoretical framework, this study investigated how destination attachment and overall satisfaction mediate the linkage between memorable tourism experiences and customer-based destination brand equity (CBDBE).

Design/methodology/approach

The authors study presents a model that illustrates how memorable tourism experiences can influence CBDBE by impacting tourists' attachment and overall satisfaction with a destination. The model was tested using empirical data obtained through a survey of 382 Indian domestic tourists. The data were analysed using the SPSS AMOS (Statistical Package for Social Sciences Analysis of a Moment Structures) programme.

Findings

This study validates the accuracy and effectiveness of the suggested conceptual model, demonstrating significant linkage between the variables of the study. Accordingly, it was observed that positive memorable tourism experiences have a notable impact on the development of attachment and satisfaction with the tourist destination forming strong CBDBE.

Practical implications

The study's primary managerial recommendation is that, to achieve sustainable competitive advantage, destination management organisations should give priority to memorable experiences and positive emotions instead than only concentrating on product-centred marketing. Second, destination managers must mould their business models based on the link between memorable tourism experiences, destination attachment, satisfaction and CBDBE.

Originality/value

Perhaps, the authors' research is one of the earliest to explore the relationship between tourists' overall satisfaction, attachment to a destination and memorable experiences and how they impact customer-based brand equity (CBBE) for a specific urban hill station destination.
Factors influencing tourists' behavioural intentions towards beach destinations: the mediating roles of destination experience and destination satisfaction
Authors: Karim Rashed Al , Rabiul Md Karim , Arfat Sayed Mohammed
Published: September 2023

Purpose

This study aims to identify factors affecting travellers' behavioural intentions regarding beach destinations in Bangladesh. The study also examines how destination experience and satisfaction mediate the nexus between destination service factors and travellers' behavioural intentions.

Design/methodology/approach

A self-administered survey was carried out to gather data from 375 people who had visited the beaches in Cox's Bazar. Data were examined using partial least squares structural equation modelling (PLS-SEM) to evaluate the hypotheses.

Findings

The destination experience mediates the relationship between destination service factors and complaint intention but does not mediate the relationship between destination service factors and word of mouth (WOM). Moreover, destination satisfaction mediated the relationship between destination service factors and WOM, along with complaint intention.

Practical implications

This study's findings can be utilised by the Bangladeshi destination management to increase the number of tourists by instituting and maintaining improved destination service features in popular tourist destinations.

Originality/value

This is one of few studies on beach tourism destinations in Bangladesh that comprehensively overviews destination service factors and their influence on tourists' behavioural intentions, with a special emphasis on the mediating roles of destination experience and destination satisfaction.
The relationship between institutional climate and constructive deviance
Authors: Dewangan Rashmi , Verghese Manoj
Published: September 2023

Purpose

This study aims to explore the impact of organizational climates on constructive workplace deviance by examining staff attitudes to four dimensions of institutional climate: academic; administrative; developmental; and financial. Though carried out with exclusively academic staff working in university environments, it has considerable potential as a pilot for adaptation to the needs of managers and carers working with intellectually challenged offenders and their families.

Design/methodology/approach

Data from a purposive (non-probability) sample of 357 academicians used in technical education in public or private organizations were collected electronically using a Likert-type questionnaire. Analytic techniques used in this study include measurement model assessment and structural equation modeling.

Findings

Respondents indicated that institutional climate significantly influences employees in how they exhibit constructive deviance in their workplace behavior. Practices such as whistle blowing, prosocial rule-breaking and openly expressing their concerns are common symptoms exhibited in constructive deviant behavior. An employee who is positively influenced by the organization’s climate would stand up against any policy or activity that could disrupt or harm the company’s operations and reputation. Results imply that, of the four climate variables analysed, financial climate has the most influence on positive deviance, followed by developmental and administrative climates, with academic climate having the least influence.

Practical implications

The current study’s target population is the academicians working as faculty members in the field of technical education, having multiple implications for the management of institutions. The findings of the study emphasize the significance of their workplace policies and ethics. Given the indication that financial climate appeared to be the most influential of the dimensions under study, this would emphasize the need to develop an environment where there is no irrelevant discrimination in pay based solely on gender, caste or creed.

Originality/value

To the best of the authors’ knowledge, this study is the first attempt to understand and describe its four key elements together as contributory factors to constructive deviance in an organization.
Sourcing strategies for competing manufacturers in the toy industry
Authors: Liang Peiyi , Yang Feng , Shan Feifei
Published: September 2023

Purpose

This paper aims to examine the optimal sourcing strategies and pricing decisions of competing toy manufacturers and to discuss how manufacturers’ decisions are impacted by competition.

Design/methodology/approach

The authors consider a single-period model to characterise the competition between two competing toy manufacturers. Both of them are free to choose between virgin material and recycled material. The authors consider two types of consumers: sensitive consumers who are concerned about product safety and prefer the toy made of virgin material and insensitive consumers who do not care what material is used in the toy. The competing manufacturers play a Cournot competition.

Findings

The results reveal a special case of a win-win situation for both the manufacturer and the consumer. In addition, an increasing number of sensitive consumers does not always raise the price of virgin-material toys.

Practical implications

The authors derive the manufacturer’s equilibrium sourcing strategies, corresponding market-clearing prices and profits obtained.

Originality/value

The paper investigates how toy manufacturers’ optimal sourcing strategies are impacted by competition, considering market segments.
Utilizing health-related text on social media for depression research: themes and methods
Authors: Yao Sumei , Wang Fan , Chen Jing , Lu Quan
Published: September 2023

Purpose

Social media texts as a data source in depression research have emerged as a significant convergence between Information Management and Public Health in recent years. This paper aims to sort out the depression-related study conducted on the text on social media, with particular attention to the research theme and methods.

Design/methodology/approach

The authors finally selected research articles published in Web of Science, Wiley, ACM Digital Library, EBSCO, IEEE Xplore and JMIR databases, covering 57 articles.

Findings

(1) According to the coding results, Depression Prediction and Linguistic Characteristics and Information Behavior are the two most popular themes. The theme of Patient Needs has progressed over the past few years. Still, there is a lesser focus on Stigma and Antidepressants. (2) Researchers prefer quantitative methods such as machine learning and statistical analysis to qualitative ones. (4) According to the analysis of the data collection platforms, more researchers used comprehensive social media sites like Reddit and Facebook than depression-specific communities like Sunforum and Alonelylife.

Practical implications

The authors recommend employing machine learning and statistical analysis to explore factors related to Stigmatization and Antidepressants thoroughly. Additionally, conducting mixed-methods studies incorporating data from diverse sources would be valuable. Such approaches would provide insights beneficial to policymakers and pharmaceutical companies seeking a comprehensive understanding of depression.

Originality/value

This article signifies a pioneering effort in systematically gathering and examining the themes and methodologies within the intersection of health-related texts on social media and depression.
Multi-performance optimization for AWJ drilling process in cutting of ceramic tile: BBD with EOBL-GOA algorithm
Authors: Tamilarasan A. , Renugambal A. , Shunmugesh K.
Published: September 2023

Purpose

The goal of this study is to determine the values of the process parameters that should be used during the machining of ceramic tile using the abrasive water jet (AWJ) process in order to achieve the lowest possible values for surface roughness and kerf taper angle.

Design/methodology/approach

In the present work, ceramic tile is processed by the AWJ process and experimental data were recorded using the RSM approach based Box–Behnken design matrix. The input process factors were water jet pressure, jet traverse speed, abrasive flow rate and standoff distance, to determine the surface roughness and kerf taper angle. ANOVA was used to check the adequacy of model and significance of process parameters. Further, the elite opposition-based learning grasshopper optimization (EOBL-GOA) algorithm was implemented to identify the simultaneous optimization of multiple responses of surface roughness and kerf taper angle in AWJ.

Findings

The suggested EOBL-GOA algorithm is suitable for AWJ of ceramic tile, as evidenced by the error rate of ±2 percent between experimental and predicted solutions. The surfaces were evaluated with an SEM to assess the quality of the surface generated with the optimal settings. As compared with initial setting of the SEM image, it was noticed that the bottom cut surface was nearly smooth, with less cracks, striations and pits in the improved optimal results of the SEM image. The results of the analysis can be used to control machining parameters and increase the accuracy of AWJed components.

Originality/value

The findings of this study present an innovative method for assessing the characteristics of the nontraditional machining processes that are most suited for use in industrial and commercial applications.
Does intention translate into actual purchase? Analysis of inducers of sustainable consumption in higher education students
Authors: Montreuil Carmona Linda JessicaDe , Barretto Anderson Gomes Paes , Bacinello Edilson
Published: September 2023

Purpose

The purpose of this study was to verify the effect of sustainable consumption on the intention and effective purchase of products by young undergraduates, using the framework with the dimensions: consciousness for sustainable consumption, moral orientation and environmental concern. The authors also examined the mediation effect of intention and searched for heterogeneities on the purchase of sustainable products when discriminating by product type.

Design/methodology/approach

Sustainable consumption assumes ethics and environmental concern prioritization in the role of individuals to preserve natural resources threatened by global warming. Considering this, the authors developed cross-sectional research based on a sample of 265 Brazilian higher education students, which was analyzed with the use of partial least squares path modeling.

Findings

The results showed a positive relationship between sustainable consumption and buying intention, with mediation effects on the effective purchase of sustainable products. It was evidenced that consciousness for sustainable consumption, moral orientation and environmental concern do not lead directly to the purchase of sustainable products; they are based on the mediation exerted by the intention that purchase materializes in Brazilian, young university students. By analyzing heterogeneities, the authors found that environmental concern may translate into actual purchase when product-oriented.

Originality/value

This study uses the VBN theory to understand the behavioral intentions for the effective purchase of sustainable products, extending the range of sustainable consumption associating factors not analyzed in the higher education context, including nontraditional categories of sustainable products, such as textiles, furniture and wood articles. Moreover, this paper examines the mediation role of intention for effective purchase of sustainable products, identifying product categories that may translate environmental concerns to actual purchases, highlighting the importance of Brazil as an emerging economy that is a leading producer and exporter of organic foods with a growing market for sustainable products.
The burden of rheumatoid arthritis and low back pain in North Africa and Middle East from 1990 to 2019: Results from the Global Burden of Disease Study 2019
Authors: Sanjari Mahnaz , Noorali Sima , Behnoush Amir Hossein , Saeedi Moghaddam Sahar , Fahimfar Noushin , Azangou‐Khyavy Mohammadreza , Yousefi Shakiba , Ebrahimi Narges , Yarmohammadi Hossein , Rashidi Mohammad‐Mahdi , Ostovar Afshin , Larijani Bagher
Published: September 2023

Background

Rheumatoid arthritis (RA) and low back pain (LBP) are among the most prevalent musculoskeletal disorders (MSDs). The need for investigation of regional and local patterns of these two MSDs seems inevitable for better policy‐making. The current study presents updated results of the Global Burden of Disease (GBD) Study 2019 and reports the burden of RA and LBP in North Africa and Middle East (NAME) countries from 1990 to 2019.

Methods

Incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), disability‐adjusted life‐years (DALYs), and risk factors, including high body mass index, occupational ergonomic factors, and smoking, were extracted based on the GBD 2019 data.

Results

The age‐standardized prevalence and mortality of RA were 120.6 (95% uncertainty interval [95% UI] 107.0–135.7) and 0.1 (95% UI 0.1–0.2) per 100 000 population in 2019 with 28.3% (95% UI 25.5%–30.9%) increase and 7.5% (95% UI −37.5% to 32.5%) decrease since 1990, respectively. Turkey had the highest age‐standardized incidence, prevalence, and DALYs of RA in 2019. All RA burden measures were higher for women; however, the incidence was almost the same at ages greater than 65 years. The age‐standardized prevalence and DALYs of LBP were 7668.2 (95% UI 6798.0–8636.3) and 862 (95% UI 605.5–1153.3) in 2019, which had decreased by 5.8% (95% UI −7.4% to −4.3%) and 6.0% (95% UI −7.7% to −4.2%) since 1990, respectively. Moreover, although Turkey had the highest incidence and prevalence in 1990, Iran was at the top in 2019. The regional age‐standardized DALY rates due to RA and LBP attributed to smoking were 1.7 (95% UI 0.5–3.2) and 139.4 (95% UI 87.3–198.8) in 2019, respectively, which had decreased 2.2% (95% UI −19.2% to 13.7%) and 15.4% (95% UI −19.4% to −10.5%) since 1990, respectively.

Conclusion

RA still imposes a significant burden in the NAME region as the burden measures have increased from 1990 to 2019. On the other hand, regarding LBP, a decreasing pattern was observed. Differences among the countries and between ages and genders can have implications, and the results of this study may be helpful for policy‐makers in the NAME countries.
Is the gut microbiome of insects a potential source to meet UN sustainable development goals to eliminate plastic pollution?
Authors: Siddiqui Ruqaiyyah , Khan Naveed Ahmed
Published: September 2023

As insects such as cockroaches can endure high radiation, flourish in unsanitary circumstances, thrive on germ‐infested feed, and can even digest the organic polymer cellulose, the gut microbiota of these species likely produces enzymes contributing to their ability to digest a variety of materials. The use of cockroaches as a bio‐resource to eliminate plastic is discussed. We explore whether species such as cockroaches are a potential bio‐resource to eliminate plastic pollution and contribute to the sustainable development goals adopted by the United Nations as well as the global community to reduce and/or eliminate plastic pollution.
rphenoscate: An R package for semantics‐aware evolutionary analyses of anatomical traits
Authors: Porto Diego S. , Tarasov Sergei , Charpentier Caleb , Lapp Hilmar , Balhoff James P. , Vision Todd J. , Dahdul Wasila M. , Mabee Paula M. , Uyeda Josef
Published: September 2023

Organismal anatomy is a hierarchical system of anatomical entities often imposing dependencies among multiple morphological characters. Ontologies provide a formal and computable framework for incorporating prior biological knowledge about anatomical dependencies in models of trait evolution. They also offer new opportunities for working with semantic representations of morphological data.

In this work, we present a new R package—rphenoscate—that enables incorporating ontological knowledge in evolutionary analyses and exploring semantic patterns of morphological data. In conjunction with rphenoscape, it allows for assembling synthetic phylogenetic character matrices from semantic phenotypes of morphological data. We showcase the package functionality with data sets from bees and fishes.

We demonstrate that ontologies can be employed to automatically set up evolutionary models accounting for trait dependencies in stochastic character mapping. We also demonstrate how ontology annotations can be explored to interrogate patterns of morphological evolution. Finally, we demonstrate that synthetic character matrices assembled from semantic phenotypes retain most of the phylogenetic information from their original data sets.

Ontologies will become important tools for integrating anatomical knowledge into phylogenetic methods and making morphological data FAIR compliant—a critical step of the ongoing ‘phenomics’ revolution. Our new package offers key advancements towards this goal.
Candidate signatures of positive selection for environmental adaptation in indigenous African cattle: A review
Authors: Kambal Sumaya , Tijjani Abdulfatai , Ibrahim Sabah A. E. , Ahmed Mohamed‐Khair A. , Mwacharo Joram M. , Hanotte Olivier
Published: September 2023

Environmental adaptation traits of indigenous African cattle are increasingly being investigated to respond to the need for sustainable livestock production in the context of unpredictable climatic changes. Several studies have highlighted genomic regions under positive selection probably associated with adaptation to environmental challenges (e.g. heat stress, trypanosomiasis, tick and tick‐borne diseases). However, little attention has focused on pinpointing the candidate causative variant(s) controlling the traits. This review compiled information from 22 studies on signatures of positive selection in indigenous African cattle breeds to identify regions under positive selection. We highlight some key candidate genome regions and genes of relevance to the challenges of living in extreme environments (high temperature, high altitude, high infectious disease prevalence). They include candidate genes involved in biological pathways relating to innate and adaptive immunity (e.g. BoLAs, SPAG11, IL1RL2 and GFI1B), heat stress (e.g. HSPs, SOD1 and PRLH) and hypoxia responses (e.g. BDNF and INPP4A). Notably, the highest numbers of candidate regions are found on BTA3, BTA5 and BTA7. They overlap with genes playing roles in several biological functions and pathways. These include but are not limited to growth and feed intake, cell stability, protein stability and sweat gland development. This review may further guide targeted genome studies aiming to assess the importance of candidate causative mutations, within regulatory and protein‐coding genome regions, to further understand the biological mechanisms underlying African cattle's unique adaption.
Impact of glaucoma medications on subsequent Schlemm's canal surgery outcome: Cox proportional hazard model and propensity score‐matched analysis
Authors: Okuda‐Arai Mina , Mori Sotaro , Takano Fumio , Ueda Kaori , Sakamoto Mari , Yamada‐Nakanishi Yuko , Nakamura Makoto
Published: September 2023

Purpose

The impact of various preoperative glaucoma medications on Schlemm's canal surgery outcomes remains unclear. This study aimed to investigate the impact of preoperative glaucoma medications on the postoperative 1‐year outcomes of μTLO.

Methods

We analyzed the medical records of 218 patients who underwent their first μTLO to investigate the 1‐year postoperative outcomes. Cox proportional hazard regression analysis was performed with surgical failure as the dependent variable and each type of preoperative medication as the independent variable. We also compared the 1‐year outcomes of μTLO between users and non‐users of specific medications using propensity score matching. Surgical success was defined as a postoperative intraocular pressure ranging from 5 to 21 mmHg, a ≥20% reduction in IOP from baseline, and no additional glaucoma surgery within 1 year postoperatively.

Results

The Cox proportional hazard analysis showed that all drugs that do not increase the conventional outflow exhibited hazard ratios greater than 1.0, and the preoperative use of β‐blockers and oral CAI was a significant surgical risk factor (hazard ratio: 2.65 and 2.45, p = 0.04 and <0.001). In the propensity score matching analysis, success rates at 1 year postoperatively were 55/85, 54/79, 60/73, and 40/76% for users/non‐users of β‐blockers, topical CAIs, an alpha‐2 adrenergic agonist, and an oral CAI, respectively. Kaplan–Meier survival curves in these comparisons also demonstrated that preoperative β‐blockers and oral CAI use were significant surgical risks (p = 0.01, <0.001).

Conclusion

Our study suggests that preoperative medications that do not involve conventional pathway outflow have a detrimental effect on subsequent Schlemm's canal surgery outcomes.
Juçara palm ecological interactions threatened by climate and land‐cover changes
Authors: Quitete Portela Rita de Cássia , Tourinho Luara , Viana dos Santos Thamyris , M. Vale Mariana
Published: September 2023

Ongoing climate change has caused well‐documented displacements of species' geographic distribution to newly climatically suitable areas. Ecological niche models (ENM) are widely used to project such climate‐induced changes but typically ignore species' interspecific interactions that might facilitate or prevent its establishment in new areas. Here, we projected the change in the distribution of Juçara Palm (Euterpe edulis Mart., Arecaceae), a neotropical threatened palm, taking into consideration its ecological interactions. We run ENMs of E. edulis, plus its known seed dispersers (15 bird species) and predators (19 birds and mammals) under current and future climatic conditions. Additionally, for E. edulis, we removed deforested areas from the model. When considering only climate, climate change has a positive impact on E. edulis, with a predicted westward expansion and a modest southward contraction, with a 26% net gain in distribution by 2060. When removing deforested areas, however, climate change harms E. edulis, with a 66% predicted net distribution loss. Within the palm's distribution in this more realistic model, there is also a predicted reduction in the richness of its dispersers and predators. We conclude that the possible benefits of climate change to E. edulis' distribution are overshadowed by widespread habitat loss, and that global change is likely to disrupt some of its ecological interactions. The outcome of the interplay between the negative impact of the loss of dispersers, and the benefit of the loss of predators, is unclear, but the large contraction of E. edulis' range predicted here foresees a dim future for the species.

Abstract in Portuguese is available with online material.
Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment
Authors: Kashiwagi Ryosuke , Funayama Ryo , Aoki Shuichi , Matsui Aya , Klein Sebastian , Sato Yukihiro , Suzuki Tsubasa , Murakami Keigo , Inoue Koetsu , Iseki Masahiro , Masuda Kunihiro , Mizuma Masamichi , Naito Hisamichi , Duda Dan G. , Unno Michiaki , Nakayama Keiko
Published: September 2023

Expression of the gene for collagen XVII (COL17A1) in tumor tissue is positively or negatively associated with patient survival depending on cancer type. High COL17A1 expression is thus a favorable prognostic marker for breast cancer but unfavorable for pancreatic cancer. This study explored the effects of COL17A1 expression on pancreatic tumor growth and their underlying mechanisms. Analysis of published single‐cell RNA‐sequencing data for human pancreatic cancer tissue revealed that COL17A1 was expressed predominantly in cancer cells rather than surrounding stromal cells. Forced expression of COL17A1 did not substantially affect the proliferation rate of the mouse pancreatic cancer cell lines KPC and AK4.4 in vitro. However, in mouse homograft tumor models in which KPC or AK4.4 cells were injected into syngeneic C57BL/6 or FVB mice, respectively, COL17A1 expression promoted or suppressed tumor growth, respectively, suggesting that the effect of COL17A1 on tumor growth was influenced by the tumor microenvironment. RNA‐sequencing analysis of tumor tissue revealed effects of COL17A1 on gene expression profiles (including the expression of genes related to cell proliferation, the immune response, Wnt signaling, and Hippo signaling) that differed between C57BL/6‐KPC and FVB‐AK4.4 tumors. Our data thus suggest that COL17A1 promotes or suppresses cancer progression in a manner dependent on the interaction of tumor cells with the tumor microenvironment.
Heterocyclic and non‐heterocyclic arena of monocarboxylate transporter inhibitors to battle tumorigenesis
Authors: Manisha Deepthi S. , Ratheesh Anandu Kizhakkedath , Benny Sonu , Presanna Aneesh Thankappan
Published: September 2023

Monocarboxylate transporters (MCTs) have gained significant attention in cancer research due to their critical role in tumour metabolism. MCTs are legends for transporting lactate molecules in cancer cells, an oncometabolite and waste product of glycolysis, acting as an indispensable factor of tumour proliferation. Targeting MCTs with inhibitors has emerged as a promising strategy to combat tumorigenesis. This article summarizes the most recent research on MCT inhibitors in preventing carcinogenesis, covering both heterocyclic and non‐heterocyclic compounds. Heterocyclic and non‐heterocyclic compounds such as pteridine, pyrazole, indole, flavonoids, coumarin derivatives and cyanoacetic acid derivatives have been reported as potent MCT inhibitors. We examine the molecular underpinnings of MCTs in cancer metabolism, the design and synthesis of heterocyclic and non‐heterocyclic MCT inhibitors, their impact on tumour cells and the microenvironment and their potential as therapeutic agents. Moreover, we explore the challenges associated with MCT inhibitor development and propose future directions for advancing this field. This write‐up aims to provide researchers, scientists and clinicians with a comprehensive understanding of the heterocyclic and non‐heterocyclic MCT inhibitors and their potential in combating tumorigenesis.
The promise of leveraging social identities in interventions to enhance the well‐being and lives of adolescents
Authors: Hoffman Adam J. , Umaña‐Taylor Adriana J.
Published: September 2023

Identity development is theorized to be a cornerstone of adolescence. An abundance of evidence has documented the significance of specific social identities (e.g., ethnic‐racial or sexual identity) in the adjustment of adolescents. Research has found that youth who have explored their social identities and have more positive views of their social groups are likely to adjust more successfully across many developmental outcomes. Given evidence documenting the importance of social identities, in this article, we argue that identities should be leveraged to promote positive adjustment, particularly among youth experiencing marginalization. We present a theoretically driven rationale for why social identities should be considered assets that provide opportunities for intervention to improve youth's lives. We also describe two interventions that efficaciously targeted social identity development and demonstrated positive effects on adjustment. We close with directions for research and implementation and a call to invest in this important work.
Combining community science and taxonomist expertise for large‐scale monitoring of insect pollinators: Perspective and insights from Abeilles citoyennes
Authors: Rondeau Sabrina , Gervais Amélie , Leboeuf Anne , Drapeau Picard André‐Philippe , Larrivée Maxim , Fournier Valérie
Published: September 2023

While evidence of insect pollinator declines accumulates, little is known about the pollinator communities that are most vulnerable to population fluctuations and may require conservation actions. Among the main reasons for this lack of knowledge about the status and trends of native pollinators are the time, cost, and expertise required to collect and identify wild insect pollinators (bees, more specifically). Here, we discuss how leveraging the complementarity of community science and taxonomist expertise can help overcome these challenges and provide perspective and insights from launching the large‐scale monitoring program Abeilles citoyennes. The overall objective of this community science project is to monitor wild bee (Apoidea) and hover fly (Syrphidae) diversity in the province of Quebec, Canada, and study the effects of landscape composition on their communities. From 2019 to 2021, 131 volunteers collected insects at 161 sites across the province. A total of 13,558 bees and 2,486 hover flies were collected and identified to species. The project protocol and potential data uses are presented, along with a discussion of the benefits and challenges of using an expert‐assisted community science approach for pollinator monitoring and opportunities for improvement.
Pharmacokinetics, safety, and tolerability of inhaled remdesivir in healthy participants
Authors: Humeniuk Rita , Juneja Kavita , Chen Shuguang , Ellis Scott , Anoshchenko Olena , Xiao Deqing , Share Aaron , Johnston Matthew , Davies Santosh , DeZure Adam , Llewellyn Joe , Osinusi Anu , Winter Helen , Girish Sandhya , Palaparthy Ramesh , Dresser Mark
Published: September 2023

Intravenous remdesivir (RDV) is US Food and Drug Administration–approved for hospitalized and nonhospitalized individuals with coronavirus disease 2019. RDV undergoes intracellular metabolic activation to form the active triphosphate, GS‐443902, and other metabolites. Alternative administration routes, including localized pulmonary delivery, can lower systemic exposure and maximize exposure at the site of action. This study evaluated the pharmacokinetics (PK) and safety of inhaled RDV in healthy adults. This phase Ia, randomized, placebo‐controlled study evaluated inhaled RDV in healthy participants randomized 4:1 to receive RDV or placebo as single doses (4 cohorts) or multiple once‐daily doses (3 cohorts). Doses in cohorts 1–6 were administered as an aerosolized solution for inhalation through a sealed facemask; doses in cohort 7 were administered as an aerosolized solution for inhalation through a mouthpiece. Safety was assessed throughout the study. Seventy‐two participants were enrolled (inhaled RDV, n = 58 and placebo, n = 14). Following single RDV doses, RDV, GS‐704277, and GS‐441524 plasma PK parameters indicated dose‐proportional increases in area under the concentration‐time curve (AUC) extrapolated to infinite time, AUC from time zero to last quantifiable concentration, and maximum observed concentration. Analyte plasma concentrations after multiple RDV doses were consistent with those for single‐dose RDV. Analyte plasma exposures were lower when RDV was administered with a mouthpiece versus a sealed facemask. The most common adverse events included nausea, dizziness, and cough. Single‐ and multiple‐dose inhaled RDV exhibited linear and dose‐proportional plasma PK. Administration of RDV via inhalation was generally safe and well‐tolerated.
Theory of mind and executive dysfunction in chronic inflammatory demyelinating polyneuropathy
Authors: Lochmann Hannah , Wyrobnik Michelle , Kupper Christin , Rewitzer Charlotte , Klostermann Fabian
Published: September 2023

Background and purpose

Although chronic inflammatory demyelinating polyneuropathy (CIDP) is understood as a disease affecting the peripheral nervous system, mild cognitive dysfunction, particularly in the executive domain, has been described to form part of the condition. Here our interest lay in CIDP‐related theory of mind (ToM) capacities as an aspect of social cognition relevant for many aspects of everyday life.

Methods

Twenty‐nine patients with CIDP and 23 healthy controls participated in this study. They were subjected to overview cognitive testing, different executive function (EF) tasks, as well as to the Faux Pas Recognition Task (FPRT) for assessing cognitive ToM and the Reading the Mind in the Eyes Test (RMET) with respect to affective ToM.

Results

Persons with CIDP and controls did not differ with respect to their overall cognitive state. However, in the German verbal fluency standard, the digit span forward and the digit span backward tests used as EF tasks patients performed significantly worse than controls. Further, performance was abnormally low in the FPRT, whilst the groups did not differ with respect to RMET results. The FPRT and digit span backward results correlated with each other.

Conclusions

Patients with CIDP showed deficits in cognitive ToM performance together with EF dysfunction, whilst affective ToM was preserved. Altogether, the results suggest that low cognitive ToM capacities in patients with CIDP arise as a particular aspect of disease‐related executive dysfunction.
A study on how social media influences on impulsive buying
Authors: Liu Huinan , De Costa Mohd Feroz Shah De Costa Bin Mohd Faris , Yasin Megat Al‐lmran Bin , Ruan Qijie
Published: September 2023

The rapid development of the Internet has led to a shift in how people communicate, with social media becoming an essential vehicle for communication and information exchange. In this context, social media influencers have emerged. With expertise in a particular field and strong influence, they can change customers' attitudes, perceptions, and behaviors. Although social media influencers have been widely studied in the marketing field, most scholars at this stage mainly study the change in customers' attitudes and purchasing behaviors towards brands, without considering the contingency of consumers' participation in influencer marketing activities in the context of social media. Plus, researchers did not pay sufficient attention to customers' impulsive purchasing behaviors. Thus, this article investigated the factors influencing customers' impulsive buying behavior in social media influencer marketing situations. This study built an elaboration likelihood model (i.e., ELM) to explore the factors and mediating variables contributing to customers' impulsive buying behavior. Questionnaires were used to explore the factors influencing customers' impulsive buying behavior in a social media influencer marketing context. Respondents' attitudes on each dimension were measured using well‐established scales from existing research, and the data were processed to draw conclusions. Findings showed that in the influencer marketing context, consumers' perceived social value and influencer expertise would not directly impact their impulsive buying behavior. Functional and emotional values could lead to impulse buying behavior, while social values would not lead to customer inspiration. Moreover, authenticity and influence both contributed to impulsive buying behaviors. The findings might have important implications for influencer marketing and further studies on impulsive buying. Companies should select authentic and influential influencers; what's more, the influencers should be sincere and enhance their influence to gain consumers' trust.
When I grow up… I don't want to be broke: The problems with child actor trust fund requirements
Authors: Gaydos Leah
Published: September 2023

Child actors have consistently been treated as typical minority laborers, with all of their earnings legally belonging to their parents. After many child actors were left with scraps at the end of their minority, Coogan's law was enacted in California to require parents of child actors to withhold some of their earnings in a trust. However, almost a century after Coogan's law was passed, there are still many child actors left with nothing. This Note proposes to both enact further union regulations to protect child actors in every state, and also to raise the required amount withheld from fifteen percent (15%) to fifty percent (50%).
The influence of infilling material strength on mechanical properties and failure mechanism of fractured sandstone
Authors: Zhang Dong‐xiao , Wang Qing , Guo Wei‐yao , Chen Le‐xin , Jiang Yu‐jing , Zhao Yong‐qiang
Published: September 2023

To reveal the failure mechanism of fractured sandstone under the influence of the infilling material strength, uniaxial compression tests, and PFC3D numerical simulation analyses were conducted on fractured sandstone with different infilling material strengths, and the influence of the infilling material strength on the basic mechanical properties of the fracture‐filled sandstone was studied. The results showed that, with increasing infilling material strength, the peak strength and elastic modulus of the specimens increased nonlinearly and eventually stabilized. The failure pattern of the specimens changed from shear to tensile. When the infilling material strength was low, a wing crack or anti‐wing crack was generated; however, when the infilling material strength was high, a vertical tensile crack was generated. From the perspective of fracture mechanics, the filling of sandstone cracks can reduce or even suppress the stress concentration effect at the prefabricated crack tip and improve the bearing capacity of the fractured sandstone.
Conceptualizing Urban Inequalities as a Complex Socio‐Technical Phenomenon
Authors: Nelson Ruth , Warnier Martijn , Verma Trivik
Published: September 2023

The United Nations World Social Report (2020) reveals that more than two thirds of the world's population live in countries where urban inequalities have increased in the last three decades. While urban inequalities are traditionally characterized as an economic issue, scholars are increasingly applying methods from geospatial analysis to study them. In the context of these advancements, it remains unclear what underlying perspectives are guiding decisions to concentrate on certain aspects of urban inequalities, while potentially ignoring others. We address this gap by reviewing the literature centered on the geospatial analysis of urban inequalities and identify three predominant research lenses from accessibility, distribution, and policy and stakeholder perspectives. As a primary contribution of this article, we connect the perspectives with ideas drawn from complexity theory to develop an overarching socio‐technical framework for how urban inequalities emerge over space and time. While traditional scientific frameworks seek to increase knowledge through causality, complexity science acknowledges the inherent challenges in defining, understanding and solving complex problems such as urban inequalities, which has profound implications for their representation, modeling and interpretation. We critically reflect on the framework through key relational themes and insights drawn from the literature and close with considerations for future research.
Synthesis of acetyl ferulic 7‐hydroxyisoflavone ester and evaluating its antioxidant activity on improving fish oil thermal stability
Authors: Wang Yang , Xue Zhiyong , Yao Yuanyuan , Yang Yalin , Ran Chao , Zhang Zhen , Zhou Zhigang
Published: September 2023

Acetyl ferulic 7‐hydroxyisoflavone ester (AHE) was synthesized and its antioxidant capacity in vitro was evaluated by free radical scavenging assay and thermo‐oxidative stability analysis of fish oil in this study. The formation of primary and secondary oxidation products can be effectively inhibited by AHE, tert‐butylhydroxyquinone (TBHQ), ferulic acid and 7‐hydroxyisoflavone. The intensity of UV‐Vis absorption spectra increased significantly, whereas the intensity of fluorescence spectra decreased obviously with the deepening of oxidation degree of fish oil. AHE significantly alleviated the degradation of unsaturated fatty acids in fish oil. The results demonstrated that AHE was more effective than TBHQ, ferulic acid and 7‐hydroxyisoflavone in retarding the oxidative degradation of fish oil during high temperature storage (80 °C). Moreover, the formation of oxidation products in fish oil followed a first‐order kinetic model, and AHE effectively reduced reaction rate constant and delayed secondary lipid oxidation process. As a result, AHE is an effective antioxidant that can stabilise fish oil.
Epigenome‐wide methylation haplotype association analysis identified HLA‐DRB1, HLA‐DRB5 and HLA‐DQB1 as risk factors for rheumatoid arthritis
Authors: Xu Jing , Chen Haiyan , Sun Chen , Wei Siyu , Tao Junxian , Jia Zhe , Chen Xingyu , Lv Wenhua , Lv Hongchao , Tang Guoping , Jiang Yongshuai , Zhang Mingming
Published: September 2023

The aim of this study was to compare nonrandom associations between physically adjacent single methylation polymorphism loci among rheumatoid arthritis (RA) and normal subjects for investigating RA‐risk methylation haplotypes (meplotype). With 354 ACPA‐positive RA patients and 335 normal controls selected from a case–control study based on Swedish population, we conducted the first RA epigenome‐wide meplotype association study using our software EWAS2.0, mainly including (i) converted the β value to methylation genotype (menotype) data, (ii) identified methylation disequilibrium (MD) block, (iii) calculated frequent of each meplotypes in MD block and performed case–control association test and (iv) screened for RA‐risk meplotypes by odd ratio (OR) and p‐values. Ultimately, 545 meplotypes on 334 MD blocks were identified significantly associated with RA (p‐value < .05). These meplotypes were mapped to 329 candidate genes related to RA. Subsequently, combined with gene optimization, eight RA‐risk meplotypes were identified on three risk genes: HLA‐DRB1, HLA‐DRB5 and HLA‐DQB1. Our results reported the relationship between DNA methylation pattern on HLA‐DQB1 and the risk of RA for the first time, demonstrating the co‐demethylation of ‘cg22984282’ and ‘cg13423887’ on HLA‐DQB1 gene (meplotype UU, p‐value = 2.90E − 6, OR = 1.68, 95% CI = [1.35, 2.10]) may increase the risk of RA. Our results demonstrates the potential of methylation haplotype analysis to identify RA‐related genes from a new perspective and its applicability to the study of other disease.