bluuebunny/crossref_metadata_2025 huggingface dataset:
La actividad etnozoológica como estrategia de fortalecimiento de destinos turísticos responsables de Ecuador
Authors: LEMOINE QUINTERO FRANK ÁNGEL , VILLACÍS ZAMBRANO LILIA MONCERRATE , HERNÁNDEZ RODRÍGUEZ NORMA RAFAELA , ZAMBRANO ARTEAGA KEILY JEFFERSON
Published: September 2024

El estudio pretende desarrollar la etnozoología como una alternativa de producto turístico dentro de las actividades recreativas turísticas aportando al fortalecimiento a la imagen de los destinos turísticos que se encuentran en el destino Sucre-San Vicente. El objetivo que se persigue es realizar un diagnóstico que permita caracterizar la existencia de especies de fauna en la zona que contribuya a desarrollar productos turísticos sostenibles que posicionen al destino en un segmento de mercado muy competitivo de índole recreativa o investigativo. EL método descriptivo permitió la contextualización por actores e investigadores referente al objeto de la investigación y de la aplicación de técnica de observación logrando precisar las especies existentes a nivel de atractivo. El levantamiento realizado asegura que la existencia de fauna en la zona permitirá desarrollar la etnozoologia como un producto turístico sostenible para el destino turismo.
 Palabras claves: Etnozoología; producto turístico; destino turístico; circuito turístico; Ecuador.
El capital social como instrumento de sostenibilidad de los cruceros turísticos. Estudio de caso en Cabo San Lucas, Baja California Sur (México)
Authors: CORONA ALVAREZ LIDIA GUADALUPE , PEINADO OSUNA NADIA ILENIA , GAMBOA MORA PATRICIA
Published: September 2024

La llegada y escala de los cruceros a los destinos turísticos precisa de la implicación y las sinergias positivas de diferentes agentes sociales, tanto del sector privado como público, para su éxito y sostenibilidad empresarial. Por ello es necesario comprender la interacción compleja entre dichos actores a partir del análisis del capital social. Esta investigación tiene, en consecuencia, el objetivo de identificar y corroborar los elementos o categorías de confianza, organización, participación y coordinación que puede proveer el capital social y sus diversas estrategias de implantación para que los cruceros turísticos puedan consolidar sus escalas en la ruta de tránsito hacia Cabo San Lucas (México). La metodología utilizada ha sido de carácter cualitativo bajo el paradigma hermenéutico-interpretativo, a través de la revisión hemerográfica de notas periodísticas sobre la llegada de cruceros al mencionado puerto y la realización de una entrevista semiestructurada a tres actores clave de este destino. Los resultados constatan la intervención del capital social en el comité local de cruceros creado en este destino y un nivel desconfianza que ha podido mantenerse con la obtención de una certificación internacional de seguridad y promoción, además de la coordinación mediante programas locales de información y seguridad, la organización de asambleas semanales y la participación en eventos del sector privado y otros organizados por el sector público federal. En conclusión, la fuente del capital social fue formal-racional y las relaciones que se generaron de tipo “unión, puente y enlace”.
Palabras clave: Capital Social; Cruceros Turísticos; Cabo San Lucas, México.
The wealth of heritage and cultural tourism in Tunisia through two different cases: the archipelago of Kerkena and the mountains of southeastern Tunisia
Authors: KEBAÏLI TARCHOUNA MOUNIRA , KEBAÏLI SAMIR
Published: September 2024

Tunisia is a country in North Africa located on the southern shore of the Mediterranean and bordering the Sahara Desert. This situation gave it a landscape diversity, although it covers only 163610 km², and it attracted several civilizations. The age of human occupation in Tunisia, its history, its passage through several civilizations and its geography, are at the origin of the wealth and diversity of its heritage. To show this heritage richness we have chosen two particular examples each having a different site from the other: The archipelago of Kerkena, located on the east coast of Tunisia in the east center, and the mountains of South East Tunisia. The particularity of Kerkena is manifested by the fixed fisheries owned by fishermen and that of the mountains of southeastern Tunisia by troglodyte houses and "Ksour".
The adaptation of the inhabitants of Kerkena to their island environment has marked this archipelago by the importance of fishing activity, especially fixed fisheries that designate an original artisanal fishing technique. However, seaside tourism is still very limited. The peculiarity in Kerkena is related to the activity of the fishing, whereas the peculiarity in the mountains of the south-east Tunisia is in relation with the original architecture of the houses troglodytes and "Ksour". These traditional buildings have exceptional historical and cultural value because of their particular architecture. Troglodyte dwellings are found mainly in the village of Matmata, located forty kilometers southwest of the city of Gabes, and occupying Mount Matmata north of the Dahar mountains. The ksour characterize the mountain range Dahar, which begins southwest of Gabes and rises south towards Medenine and Tataouine.
The present work is a study of the relationship between heritage wealth and cultural tourism in Kerkena and the mountains of southeastern Tunisia. We will present the cultural offer of the two cases, then we will analyze the impacts of heritage wealth on tourism development for both examples, finally we will present proposals for the development of cultural tourism for the local population in Kerkena, in the mountains of the southeast and in general in Tunisia. The objective is to show the originality of the tourist offer in Tunisia for the development of mainly cultural alternative tourism. The methodology is based on the reading of various books and articles and on the field study including the interview with the local population.
Key words: heritage, fixed fishery, troglodyte houses, ksour, local population.
Kitsch landscapes as tourist destinations in South and Southeast Asia (China, Vietnam, Nepal)
Authors: BACHIMON PHILIPPE , GAUCHE EVELYNE , THUR LÊ ANH
Published: September 2024

Carried out within the framework of the AQAPA programme 2014-2019 of the French National Agency for Research (Agence Nationale de la Recherche, ANR), this study focuses on the stereotypical kitsch-based “staging” of tourist sites and resorts, taking as examples three Asian tourist regions characterized by the presence of ethnic minorities: Da Lat in Vietnam, Pokhara in Nepal and Sandu in China. This staging notably relies on the use of false décors (Baudrillard, 1981) – what Umberto Eco (1985) called an “artistic lie” – and aims to provide the tourist with “a reassuring but artificial vision of things” (Menon, 2006). This article thus looks at this kitschifying of landscapes developed for tourism at the rural/urban interface (scenography, experience provided for tourists, processes mobilized) and the objectives it serves, in order to start to understand and interpret the underlying message(s).
Keywords: landscape, kitsch, tourism development, governance, Vietnam, China, Nepal.
Reglamento del Comité de Integridad Científica
Authors:   Universidad Científica del Sur
Published: September 2024

Reglamento del Comité de Integridad Científica. Versión 1.0 (2017).
Código de ética en la investigación
Authors:   Universidad Científica del Sur
Published: September 2024

Código de ética en la investigación. Versión 1.0 (2017).
Lineamiento – Registro de propuestas de investigación
Authors:   Universidad Científica del Sur
Published: September 2024

Lineamiento para el registro de propuestas de investigación. Versión 1.0
Lineamiento – Asignación de bonificaciones a editores y directores de revistas científicas
Authors:   Universidad Científica del Sur
Published: September 2024

Lineamientos para la asignación de bonificaciones – Editores y directores de revistas científicas publicadas por la Universidad. Versión 2.0 (2023).
Lineamiento – Asignación de bonificación a la producción científica
Authors:   Universidad Científica del Sur
Published: September 2024

Lineamiento – Asignación de bonificación a la producción científica. Versión 5.0 (2024).
Lineamiento – Pago por derechos de publicación en revistas indizadas
Authors:   Universidad Científica del Sur
Published: September 2024

Lineamiento – Pago por derechos de publicación en revistas indizadas. Versión 3.0 (2024).
WITHDRAWN: Characterization of the bla VEB-3 bearing IncC plasmid and bla KPC-2 bearing IncFII plasmid in a type I-E CRISPR-Cas system harboring Klebsiella oxytoca stain
Authors: Zhong Yu-Xia , Liu Wan-Ting , Yuan Pei-Bo , Yang Ling , Xu Zhenbo , Chen Ding-Qiang
Published: September 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Transplantation of Derivative Retinal Organoids from Chemically Induced Pluripotent Stem Cells Restored Visual Function
Authors: Jin Zi-Bing , Zhao Ning , Zhang Chang-Jun , Zhang Xiao , Su Bing-Nan , Jin Kangxin
Published: September 2024

As an emerging type of pluripotent stem cells, chemically induced pluripotent stem cells (CiPSCs) avoid the risks of genomic disintegration by exogenous DNAs from viruses or plasmids, providing a safer stem cell source. To verify CiPSCs’ capacity to differentiate into retinal organoids (ROs), we induced CiPSCs from mouse embryonic fibroblasts by defined small-molecule compounds and successfully differentiated the CiPSCs into three-dimensional ROs, in which all major retinal cell types and retinal genes were in concordance with those in vivo. We transplanted retinal photoreceptors from ROs into the subretinal space of retinal degeneration mouse models and the cells could integrate into the host retina, establish synaptic connections, and significantly improve the visual functions of the murine models. This proof-of-concept study for the first time demonstrated that CiPSCs could differentiate into ROs with a full spectrum of retinal cell types, and provided new insights into chemical approach-based retinal regeneration for degenerative diseases.
Computational Development of mushroom-6-Glucan/Paclitaxel as a Synergistic Complementary Medicine for Breast Cancer Therapy
Authors: EL-Deeb Nehal , Ibrahim Omar , Kamel Ayman , Gomaa Ahmed , Kenawy Ahmed
Published: September 2024

Background
Breast cancer is chemo-resistant and highly metastatic, often resulting in patient mortality. One of the primary factors contributing to the metastasis and chemotherapy resistance is the presence of cancer stem-like cells. We posited that the natural polysaccharide known as 6-glucans, derived from Pleurotus ostreatus, could effectively counteract the chemotherapy resistance associated with cancer stem-like cells in breast cancer.
Methods
We computationally developed a specific dual combinatorial therapy involving 6-glucans and Paclitaxel (PTX) and tested on preclinical 3D mammosphere human tumor models representing receptor-positive and receptor-negative breast cancer. Using this preclinical 3D spheroid technology, we tested the anti-cancer properties of these predicted treatment combinations on mammospheres containing human breast cancer stem cells.
Results
Among the 40 distinct combinations examined, computational prediction revealed that the addition of 2.0 mg/mL of 6-glucans to a low dose of 3.0 µg/mL PTX was the sole combination demonstrating a synergistic effect. This optimized synergistic combination therapy displayed a significant inhibitory impact on human cancer epithelial and stem cell migration, evasion, and colony formation. The inclusion of 6-glucans also augmented apoptosis in both breast cancer cells and stem cells, leading to a six-fold reduction in BrdU labeled cells and an increased arrest of cells in the sub-G0 phase. These effects were mediated through mitochondrial dysfunction and the downregulation of associated oncogenes.
Conclusion
Our study revealed that the computationally predicted 6-glucans-based binary complementary medicine exhibited sequence- and concentration-dependent anticancer synergistic effects.
Comparison and optimization of mining area division schemes for Baorixile open-pit coal mine based on improved AHP-EWM method
Authors: LIU Guangwei , REN Chonghui , JU Xingjun , WANG Han , LIU Xin
Published: September 2024

Taking the remaining resource areas of the Baorixile open-pit coal mine in the Chenbalhu Banner mining area as the premise, the optimization problem of the remaining mining area division plan of the Baorixile open-pit coal mine was studied. Based on fully considering the current production situation, an improved analytic hierarchy process (AHP) and entropy weight method (EWM) combined with the method of approaching the ideal solution (TOPSIS) were constructed to conduct theoretical research using a multi-scheme and multi-index scheme optimization model, and combined it with A comparative analysis of two traditional evaluation models, the AHP method and the uncombined EWM method was conducted, and the advantages of the improved AHP-EWM method over the traditional method were elaborated. Then, the three remaining mining area division schemes proposed for the Baorixile open-pit coal mine were analyzed. In the case of twelve evaluation indicators, the closeness of the three decision-making schemes to the positive and negative ideal points of the TOPSIS method was calculated. Based on the principle that the decision-making scheme is closest to the positive ideal solution, the decision-making scheme was selected in terms of economic benefits, long-term development, and subsequent mining area continuation—the optimal decision-making solution from all angles. Option three also verified the effectiveness and practicability of the improved AHP-EWM method. It provided reference value for other open-pit coal mines to propose various mining area division decision-making plans with certain theoretical and practical significance.
Enhanced exosome secretion regulated by microglial P2X7R in the medullary dorsal horn contributes to pulpitis-induced pain
Authors: Zhang Jing , Yu Zhuo , Wang Mingjun , Kang Xiaoning , Wu Xiaoke , Yang Fengjiao , Yang Lu , Sun Shukai , Wu Li-an
Published: September 2024

Background
Pulpitis is a prevalent oral disease characterized by severe pain. The activation of microglia in the medullary dorsal horn (MDH) is reportedly essential for the central sensitization mechanism associated with pulpitis. And the P2X7 receptor (P2X7R) on microglia can trigger secretion of exosome enriched in IL-1β, which is involved in the inflammation. Thus, we hypothesized that enhanced exosome secretion regulated by microglial P2X7R in the MDH contributes to pulpitis-induced pain.
Methods
The male SD rats were chosen as experimental animals and the experimental pulpitis model was established to observe the rat’s pain behavior. Immunofluorescence staining, western blot and quantitative real-time PCR, were used to analyze the expression of Rab27a and IL-1β. The exosome inhibitor GW4869 and P2X7R antagonist Brilliant Blue G (BBG) were performed to analyze the correlation between microglial P2X7R, exosome secretion and inflammation in the pulpitis model. In vitro, microglia cell lines were cultured to collect exosomes, and stimulation of lipopolysaccharide (LPS), oxidized ATP (oxATP) and GW4869 detected changes in exosome secretion and inflammatory factors.
Results
In the experimental pulpitis model, the degree of microglial exosome secretion and inflammatory factor release in the MDH was correlated with the degree of pulpitis-induced pain, with the highest expression on the 7th day. GW4869, as well as BBG, could inhibit Rab27a and IL-1β expression, reducing pulpitis-induced pain. In addition, exosomes were successfully extracted by ultracentrifugation in vitro, LPS treatment could promote the exosome secretion, while GW4869 had an opposite role on the secretion of exosomes and inflammatory factor IL-1β. Moreover, P2X7R inhibition by oxATP also diminished exosome secretion, leading to a reduction in inflammatory responses.
Conclusion
This study indicates the regulatory role of microglial P2X7R in increased exosome secretion, implicating the potential utility of P2X7R as a promising target for pulpitis therapy. And our research provides a new pulpitis mechanism that exosomes enriched in IL-1β contributed to pulpitis-induced pain, suggesting the crucial role of exosomes as pain biomarkers and harmful signal bearers in pulpitis.
Engineering 2D Spin Networks by “on-surface” Encapsulation of Azafullerene Radicals in Nanotemplates
Authors: Cvetko Dean , Kladnik Gregor , Schio Luca , Bavdek Gregor , Tanuma Yuri , Mavrič Marion van Midden , Zupanič Erik , Anézo Bastien , Sideri Ioanna , Tagmatarchis Nikos , Volkmann Jannis , Wegner Hermann A. , Goldoni Andrea , Ewels Christopher , Morgante Alberto , Floreano Luca , Arcon Denis
Published: September 2024

We present an efficient strategy for on-surface engineering of organic metal-free supramolecular complexes with long-term spin protection. By vacuum deposition of azafullerene (C59N•) monomers on a pre-deposited template layer of [10]cycloparaphenylene ([10]CPP) nanohoops on Au(111) surface we exploit the molecular shape matching between the C59N• and [10]CPP for the azafullerene encapsulation with nanohoops in a guest-host complexation geometry. C59N•⊂[10]CPP supramolecular complexes self-assemble into an extended two-dimensional hexagonal lattice yielding a high density network of stable spin-1/2 radicals. We find compelling evidence for electronic coupling between the guest C59N• and the host [10]CPP in supramolecular species. At the same time, [10]CPP effectively protects the radical state of encapsulated azafullerenes against dimerization and inhibits C59N• coupling to the Au substrate. Azafullerene encapsulation by nanohoops represents a viable realization of molecular spin protection while simultaneously demonstrating exceptional self-assembling properties by which large-scale 2D architectures of molecular spins can be realized.
Sarayönü Region (Türkiye) Potential Toxic Element Content, Spatial Distribution, Ecological and Human Health Risks of Agricultural Lands and Wheat
Authors: ODEN Muhammed Kamil , HORASAN Bilgehan Yabgu , OZDONER Ali , SARICOBAN Cemalettin
Published: September 2024

Today, the beginning of many environmental problems is related to soil pollution. Potential toxic element accumulation in soils has the feature of persistence and accumulation for many years. Potential toxic elements can show point and diffuse spatial distribution by being carried to some extent near their source point. Potential toxic elements may cause a decrease in the quality of products in areas where they are distributed, and they may enter the food chain and put human health at risk. Sarayönü is one of the most important agricultural centers of Konya province. Approximately 10% of the agriculture activities of Konya province are carried out in the district where there is no heavy industry. Mercury mining has been carried out within the district borders in historical periods and the last fifty years. Some other potentially toxic elements, especially mercury, and arsenic, have been transported to some extent and dispersed spatially through abandoned mines, mining activities, and streams passing near ore zones. Chemical analysis of soil and wheat samples was performed. The results of soil samples are average, 16 (Cu), 2.1 (Pb), 66.4 (Zn), 0.52 (Ni), 5 (Mn), 22876 (Fe), 14.8 (As), 0.025 (Cd), 14 (Cr), 15116 (Al) and 0.71 (Hg) ppm values were found. The results of wheat samples were Hg (0.100), As (0.100), Pb (0.130), Zn (0.400), Cu (0.30), Ni (0.060), Cr (0.35), Cd (0.0094), Al (1.60) and Fe (0.95). The results were found to be well below the reference values ​​taken in Turkey and the World. According to the results in the soil, significant contamination of mercury and arsenic was detected in ecological risk factors at locations S1 and S7. No high carcinogenic risk was detected for children and adults in the field.
Perinatal outcomes in new-borns of pregnant women with COVID-19: a case-control study
Authors: Dutra Letícia Veríssimo , Gonçalves Giovana , Silva Mariliza Henrique , Lebrão Cibele , Affonso‑Fonseca Fernando , Suano‑Souza Fabiola
Published: September 2024

Background
The incidence of COVID-19 vertical transmission is approximately 20%, and a shorter interval and greater maternal infection severity increase the risk of mother-to-child transmission.
Objective
This study aims to describe the frequency of COVID-19 positivity and clinical symptoms in newborns of pregnant women who have had COVID-19.
Methods
A case‒control study was carried out with unvaccinated women who had COVID-19 during pregnancy and their newborns. The 23 newborns that tested positive for COVID-19 (RT‒PCR for SARS-CoV-2) in the first 48 hours of life were matched (2:1) by day of birth and sex, with 46 other newborns that tested negative for COVID-19. The following data were collected: time and severity of maternal infection, gestational age, anthropometry, and clinical symptoms of the newborns.
Results
The mean age of the pregnant women was 28.50 ± 6.39 years, and the median time between COVID-19 infection and delivery was 86.0 days (26.5,179). The mean gestational age and birth weight of the newborns were 38.2 ± 1.7 weeks and 2994.2 ± 464.5 grams, respectively. Fifteen (21.7%) of the newborns experienced clinical complications during hospitalization, and the most common complications were early respiratory distress (10.1%), hypotonia/hypoactivity (13.0%), hypoglycemia (1.4%), and vomiting (1.4%). Newborns with positive RT‒PCR results for SARS-CoV-2 had a greater risk of respiratory symptoms (OR = 21.31; 95% CI 2.24 to 201.68; p = 0.008), and the likelihood of positivity in newborns increased by 0.07% (OR = 1.007; 95% CI 1.001 to 1.014; p = 0.026) for each day of COVID‒19 infection during pregnancy closer to birth.
Conclusions
Newborns who tested positive for SARS-CoV-2 were at greater risk of respiratory disorders, and maternal infection closer to birth increased the likelihood of positivity in newborns. There was no association between infection with COVID-19 in newborns and the severity of maternal infection, prematurity, or birth weight.
Ignored or underestimated - Evaluation and treatment of cardiovascular risk factors in patients with adrenal insufficiency Undertreatment of cardiovascular risk factors in patients with adrenal insufficiency
Authors: Wasmuth Anja , de Loo Iris van , Domberg Julia , Harbeck Birgit
Published: September 2024

Purpose
Patients with adrenal insufficiency (AI) are known to have a higher cardiovascular risk (CVR) than the normal population. In particular arteriosclerosis, coronary heart disease, arterial hypertension, hyperlipoproteinemia as well as metabolic disturbances contribute to the increased morbidity and mortality. Aim of this study was to evaluate known CVR factors along with the quality of care by the treating physicians.
Methods
To this end the medical records of AI patients were screened for CVR factors and the treatment initiated was documented. In addition, a questionnaire evaluating CVR factors was analyzed if available.
Results
In total, 327 AI patients were included in the study. At least 298 of these patients were found to have one or more CVR factors. Ninety-one patients were diagnosed with arterial hypertension, of these 40 patients (44%) still showed increased blood pressure (BP) values. Of all AI patients, about 25% (n = 83) did not have measurements to calculate their BMI, even though obesity is known as a major risk factor for cardiovascular events. Out of 46 patients with diabetes, one-quarter still had increased HbA1c values. Regarding hyperlipoproteinemia, only 4% of AI patients achieved normal lipid values across all parameters (n = 12). Interestingly, at least one lipid variable was untested in 150 patients (46%).
Conclusion
Our study demonstrates (1) the high rate of CVR factors in AI patients, leading to increased morbidity and eventually mortality, (2) AI patients are inadequately monitored and treated for CVR factors, (3) treating physicians should be aware of this risk to minimize complications where possible.
Late Lymphocele Infection with Parvimonas micra in a Kidney Allograft Recipient
Authors: Dkhissi Rihab , Ouellet Gabriel , Charmetant Xavier , Buron Fanny , Valour Florent , Rouvière Olivier , Matillon Xavier , Morelon Emmanuel
Published: September 2024

Background
Lymphocele infection is a frequent and usually early complication following renal transplantation. We report the case of a transplanted patient with a chronic lymphocele that became infected six years after transplantation Parvimonas micra, a commensal of the human oral cavity.
Case presentation
: The patient had a stable lymphocele for six years post-transplantation over several medical imaging. Regarding a six-month progressive decline in general condition, a persistent inflammatory syndrome and a deterioration of renal function, a PET scan revealed a hypermetabolic infiltration behind the lymphocele adjacent to the graft. Bacterial superinfection with Parvimonas micra was diagnosed by an exploratory puncture. The patient had a history of dental periodontal treatments. The initial attempt at treatment with radiological drainage and three months of antibiotic therapy was unsuccessful. Faced with radiological deterioration despite treatment, the patient underwent surgical intervention for lavage with necessary antibiotic therapy for an additional six weeks. He achieved clinical remission, but metabolic activity persists within the site of a residual collection, and the patient remains closely observed.
Conclusions
Infected lymphoceles should be considered in the differential diagnosis for patients presenting with nonspecific infectious and inflammatory symptoms, regardless of the time elapsed since renal transplantation. The treatment of this complication can be complex.
The causal relationship between inflammatory cytokines and thrombocytopenia: A bidirectional two-sample Mendelian randomization study
Authors: Hong Kimsor , Hun Marady , Wu Feifeng , Mao Jueyi , Wang Yang , Zhu Junquan , Zhou Xin , Xie Haotian , Li Binbin , Qiu Xinying , Tian Jidong , Zhang Liang , Wen Chuan
Published: September 2024

Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by increased platelet destruction and impaired thrombopoiesis. Epidemiological and experimental evidence has linked inflammation cytokine levels to ITP etiology but is uncertain. To respond to this query, we conducted a Mendelian randomization (MR) analysis to investigate the causal effects of circulating cytokine levels on ITP development. Using summary statistics from genome-wide association studies (GWAS), we obtained data on 41 serum cytokines from 8,293 Finnish individuals and ITP data from a meta-analysis of the FinnGen consortium, UK Biobank, and BioBank Japan. The association between genetically predicted levels of inflammatory cytokines and ITP was estimated using a bidirectional Mendelian randomization (MR) study. Sensitivity analyses and the False Discovery Rate (FDR) method were also performed to verify the robustness of the results. We discovered that higher genetically predicted M-CSF levels were strongly associated with an increased risk of ITP (OR: 1.09; 95%CI: 1.03–1.16; p = 0.003) and gestational thrombocytopenia (GT) (OR: 1.17; 95%CI, 1.05–1.32; p = 0.006). Additionally, our results showed an adverse association between genetically predicted levels of the circulating HGF (OR: 0.75; 95%CI, 0.63–0.90; p = 0.002), MIF (OR: 0.90; 95%CI, 0.84–0.96; p = 0.001) and TRAIL (OR: 0.92; 95%CI, 0.87–0.97; p = 0.003) with the GT. The study result links genetic predisposition to elevated M-CSF levels with increased risks of ITP and GT, suggesting that targeting cytokines could aid in ITP prevention, though further validation is needed.
Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis
Authors: Yan Biao , Ye Fan , Zhang Ziran , Shi Lianjun , Mu Wan , Lu Shuting , Li Xiumiao , jiang qin
Published: September 2024

Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Disruption of this process is implicated in diseases such as cancer, inflammation, and autoimmune disorders. In this study, we elucidate the role of tsRNA-0032 in lymphangiogenesis and its molecular mechanisms. tsRNA-0032 expression is significantly diminished in corneal suture and LPS-induced human lymphatic endothelial cell (HLEC) models under inflammatory conditions. Overexpression of tsRNA-0032 suppresses lymphangiogenesis by inhibiting HLEC proliferation, migration, and tube formation. Moreover, overexpression of tsRNA-0032 inhibits suture-induced mouse corneal lymphangiogenesis in vivo. tsRNA-0032 is mainly found in the cytoplasm and interacts with Ago2 protein. Overexpression of tsRNA-0032 leads to a reduction in ATP production and lowers the levels of pyruvate and lactate by targeting PKM2, which is crucial for the final step of glycolysis. This regulation of glycolysis impacts the cellular energy and metabolic balance in HLECs, contributing to the inhibition of lymphangiogenesis. Clinical data show that tsRNA-0032 levels are markedly lower in corneal tissues from transplant recipients compared to donors, whereas PKM2 expression is elevated, underscoring the clinical significance of the tsRNA-0032/PKM2 axis in corneal lymphangiogenesis. This study provides novel insights into lymphangiogenesis regulation and offers potential therapeutic targets for lymphatic-related diseases.
A Performance-centric Topology for Hybrid Wireless-Network-on-chip
Authors: Rahaman Munshi Mostafijur , Ghosal Prasun , Giri Chandan
Published: September 2024

Wireless Network-on-Chip (WNoCs) has flourished rapidly and successfully in mitigating conventional Network-on-Chips (NoCs) performance constraints. As retaliation, WNoCs initiate a preamble for present-day NoC state-of-the-art to evolve at the cutting edge of scalability and architectural expandability. Reduced latency, broadcast aid, and system-level plainness build on-chip wireless communication , an emerging choice during network-on-chip architecture development. In this work, a hybrid WNoC is designed from a mix of wireless and wired mode NoCs supported by an appropriate routing method and topology scheme. The performance measurement of the proposed WNoC design has been done comparably under distinct types of synthetic traffic patterns and benchmark frameworks concerning throughput, latency, and energy at varied workloads. Examination results of the proposed approach specify a lessening of the average latency up to 88.64% and a reduction of energy up to 90.08% with a significant gain in throughput up to 91.62%.
Medicinal Cannabis Formulations, Administration Routes and Dosing: Perspectives of Adults with Cancer
Authors: Nayak Manan M. , Chai Peter R. , Tung Stephanie , Revette Anna , Braun Ilana M.
Published: September 2024

Introduction: One-of-three or -four adults with cancer turns to medicinal cannabis. Prior work suggests a disconnect between the clinical preferences of oncology teams and the cannabis therapeutics practices of patients. For instance, oncologists favor oral administration, while many cancer patients combust or vaporize. This investigation explored medicinal cannabis (MC) formulations, routes of administration, and dosing preferences among adults with cancer.
Methods: Semi-structured phone interviews across eight states with adults with cancer consuming MC in compliance of state law were conducted and analyzed using applied thematic analysis.
Results: Among study participants (N=24), mean age was 54 years. Sixty-seven percent were female. Forty-six percent resided in the Eastern United States and 51% described their cancer as metastatic or incurable. Across interviews, a powerful theme was of myriad MC product formulations available through a given dispensary storefront, triggering astonishment and sometime feelings of inundation. Common strategies among participants were to purchase and sample multiple store-bought formulations as well as to modify dispensary products at home, at times to alter intended routes of administration or to reduce financial toxicity. A trusted, preferred dispensary product was not always consistently available. Although oral was the top-cited administration mode, the wide array of cannabis consumption methods included topical, sublingual, vaporization, combustion, and rectal suppository. Three-quarters of participants alternated between modes of administration. Medicinal cannabis dosing imprecision constituted another powerful theme, thought to be due to lack of quality assurance at the level of the dispensary and measurement imprecision in the home.
Discussion: This investigation suggests that MC preparations, administration routes and dosing vary dramatically among individuals with cancer; and that the few commonalities in use patterns, for instance reliance on multiple routes of cannabis administration, tend not be rooted in scientific evidence. These qualitative finding should be interrogated quantitatively but indicate that lay-facing educational programs pertaining cannabis therapeutics in the setting of cancer, as well as a higher degree of dispensary product standardization may be warranted.
A Comparative Study of the Seismic Performance of Self-Centering CRBFs and BRBF systems
Authors: Ramadan Mostafa , Abou-Elfath Hamdy , Turkomany Mohab
Published: September 2024

The current seismic design philosophy of building structures relies on the inelastic response of the main structural elements as the principal source for dissipating the seismic energy. The product of this philosophy is considerable levels of residual drifts that could make building structures look unsafe to their occupants. Recently, considerable research efforts were directed toward the invention of self-centering (SC) lateral load-resisting systems that are able to prevent damage in the main structural elements as well as reduce the residual deformations to minimal levels. One of these SC systems is the recently proposed controlled rocking braced frame (CRBF) system. The SC-CRBFs have shown to be a suitable alternative to conventional systems such as buckling-restrained braced frames (BRBFs). This paper performs a comparative study on the seismic performance of SC-CRBFs and BRBF systems. Two prototype buildings having 3- and 6-story are designed using BRBF and SC-CRBF systems. The buildings are subjected to pushover static loading and a suite of earthquake records. The maximum and residual lateral drifts are considered the main performance parameters for the seismic performance evaluation. The findings of this study indicate that the SC-CRBF systems exhibit superior seismic performance in comparison with traditional BRBF systems.
Design of low ripple interleaved parallel switching capacitors bidirectional DC converter based on magnetic integration technology
Authors: Mao Ling , Wang Jian , ZHAO Jinbin
Published: September 2024

To solve the probleµ of large current ripple on the low-voltage side of the interleaved switched capacitor bidirectional converter in the energy storage systeµ, an interleaved parallel switched capacitor bidirectional DC/DC converter based on coupled inductors by using µagnetic integration technology is proposed. the µagnetic core can be effectively shared by integrating the discrete inductors on the low-voltage side of the converter into a coupled inductor, and the coupling coefficient is adjusted to fully utilize the core flux, thereby increasing the inductance value and iµproving the current ripple on the low-voltage side. Based on the analysis of the relationship aµong the inductance value, duty cycle and coupling coefficient under different µodes of the converter, this paper finds the functional relationship between the converter ripple current and the coupling coefficient. The siµulation results show that when the coupling coefficient is greater than 0, the current ripple decreases on the low-voltage side gradually as the coupling coefficient increases. Finally, a 150W experiµental prototype is built for verification. The efficiency of the converter is 91.28%. When the coupling coefficients are 0.15 ,0.63 and 0.82, the current ripple on the low-voltage side was reduced by 9.88%, 37.03% and 44.44%, respectively.
Synthesis, crystal structure, and Hirshfeld surface analysis of (E)-N, N´-ethylene-1,2- diamino-bis (N, N-dimethylbut-2-enamide)
Authors: Ganesan M. , Ayyappan A. , Arockiasamy S.
Published: September 2024

The compound, (E)-N, N´-ethylene-1,2-diamino-bis(N, N’-dimethylbut-2-enamide) was synthesized by a reaction between N, N´-dimethylacetoacetamide and ethylenediamine in a methanolic medium. The Schiff base compound was characterized by infrared (IR) spectroscopy, mass spectrometry (MS), thermogravimetry (TG), and single-crystal X-ray diffraction (XRD). The compound was crystallised in a triclinic crystal system with a space group of P-1. The amine functional group (-C = N-) was confirmed by the band at 1592 cm− 1 in its IR spectrum. The compound is thermally stable from 40–203 oC losing only 1.4% of its weight. The thermogram (TG) indicated the absence of any water of hydration or lattice water. The compound exhibits keto-enol tautomerism with a zwitterionic structure. The major contributors to the Hirshfeld surface (HS) contacts are H—H (71%), O—H (11.7%), and C—H (12.2%). The crystal parameters are, a = 6.3623(4) Å, b = 6.5585(4) (8) Å, c = 10.8135(7) Å, Z = 4, R1 = 0.0610, wR2 = 0.1447. α = 98.16 (4)o, β = 95.86(4)o, γ = 117.63(4)o.
Using a citizen science approach to assess nanoplastics pollution in remote high-altitude glaciers
Authors: Jurkschat Leonie , Gill Alasdair , Milner Robin , Holzinger Rupert , Evangeliou Nikolaos , Eckhardt Sabine , Materić Dušan
Published: September 2024

Nanoplastics are suspected to pollute every environment on Earth and reach very remote areas, e.g. via airborne transport. We approached the challenge of measuring environmental nanoplastics by combining high-sensitivity TD-PTR-MS (thermal desorption-proton transfer reaction-mass spectrometry) with trained mountaineers sampling high-altitude glaciers (“citizen science”). We analysed particles < 1 µm for common polymers (polyethylene, polyethylene terephthalate, polypropylene, polyvinyl chloride, polystyrene and tire wear particles), revealing nanoplastic concentrations ranging from 2–80 ng mL− 1 at five of 14 sites. The major nanoplastic polymer types found in this study were tire wear, polystyrene (PS) and polyethylene (PE) particles (41%, 28% and 12%, respectively). FLEXPART modelling was used to reconstruct possible sources of micro- and nanoplastic emissions for those observations, appearing to lie largely to the west of the Alps, where France, Spain and Switzerland have the highest contributions.
Exercise Intensity of the Traditional Chinese Mind–Body Exercise, Baduanjin, during Performance amongst Beginners
Authors: Shi Mengni , Zhou Xin , Guo Lei , Fang Min , Li Jing Xian , Zhu Qingguang
Published: September 2024

Objective
The traditional Chinese mind–body exercise, Baduanjin, has remained popular for a thousand years for strengthening the body, promoting health and preventing chronic diseases. However, research on its exercise intensity is lacking. This study measured the exercise intensity of beginners practicing Baduanjin to provide scientific evidence for health promotion and exercise prescriptions.
Methods
A total of 20 healthy adults (13 males, 7 females) aged between 35 and 45 years, who had not practiced Baduanjin previously, were recruited. The average METs, HR, HRR, VO2, VO2/kg, VO2/HR, RR, RQ and VE were measured using the Italian Cosmed/K5 wireless portable exercise cardiopulmonary testing system.
Results
The average METs during Baduanjin was 2.92 ± 0.65. The mean maximum and mean average HR were 109.35 ± 17.83 and 95.34 ± 13.99, respectively. During Baduanjin, the exercise intensity indicators showed significant increases (P < 0.001) in VO2, VO2/kg, METs, HR, VO2/HR, RR and VE compared with the resting state. Additionally, the mean RQ increased (P < 0.05).
Conclusion
Baduanjin is a low-intensity exercise for beginners. HR reached its maximum in the later stages of Baduanjin, significantly decreased immediately after exercise and returned to near-resting levels within three minutes post-exercise. Baduanjin, as a low-intensity exercise, could be recommended for population members suitable to practice.
Establishing a cancer cohort in Latin America: The Mexican Teachers Cohort
Authors: Gómez-Flores-Ramos Liliana , Brochier Marion , Stern Dalia , Garcia-Anaya Antonio , Cortés-Valencia Adrian , Jaen Jocelyn , Sánchez-Blas Hugo R. , Lozano-Esparza Susana , Catzin-Kuhlmann Andrés , Hernández-Ávila Juan Eugenio , Pon Angélica , Rivera-Ontiveros Olga , Miranda-Aguirre Pabel , Pérez-Escobedo Patricia , Castellanos Alberto , Chávez-Cárdenas Mildred , Mohar Alejandro , López-Ridaura Ruy , Romieu Isabelle , Hernández-Avila Mauricio , Lajous Martín
Published: September 2024

Purpose
In Latin America, prospective cancer research is restricted by limited access to cancer outcome data. In this study, we demonstrate a strategy for identifying incident breast cancer cases within an established prospective cohort, the Mexican Teachers’ Cohort (MTC), through the use of self-reports, electronic health records (EHRs), administrative databases, and registries.
Methods
The MTC consists of 115,275 female teachers aged 25 years and older who completed a questionnaire on reproductive history, lifestyle, and health between 2006 and 2008. We used self-reported breast cancer, mortality and cancer registries, and EHRs and administrative databases for case ascertainment. Person-time was calculated from the date of baseline questionnaire response to diagnosis, death, or December 31, 2019. We estimated age-specific and age-standardized incidence rates for breast cancer.
Results
We identified 1,313 incident breast cancers; 94% were confirmed through registries and/or databases, and 6% directly by contacting participants. The crude breast cancer incidence was 102 per 100,000 person-years, with the highest incidence in women aged 65–69 (185 per 100,000 person-years). The age-standardized incidence was 77 per 100,000. Over one-third of cases (n = 476) occurred in women younger than 50 years.
Conclusion
The efficient identification of participants with incident breast cancer in the MTC demonstrates that prospective cancer cohorts can be successfully established in Latin America.
Continuous liquid supply multi-material DLP 3D printing
Authors: Wu Lei , Sun Jiawei , Xiong Wangjun , Zhang Lidian , Song Yanlin
Published: September 2024

Digital light processing (DLP) 3D printing has been considered as one of the most sustainable additive manufacturing methods for high-speed and high-resolution construction across various fields. Recent investigations focus on curing surface and resin formation regulation to realize printing continuity. However, heat accumulation from light-curing exotherm is aggravated and multi-material printing is compromised with the realization of printing continuity. Here, we propose a continuous liquid supply 3D printing strategy through introducing supplied liquid into one-droplet 3D printing system. Timely curing of slices can be maintained inside droplet reservoir along with on-demand resin supply, decreased heat accumulation and unlimited printing volume can thus be realized. Additionally, supply species, quantity and distribution are controllable in slices, leading to continuous mode of muti-material printing. Multi-material 3D structures with controllable morphologies and distributions can be prepared with enhanced interfacial mechanical properties and clear boundaries, and has been applied in material distribution defined 3D anti-counterfeiting and magnetic-responsive moving trajectories, which guarantees a high efficiency and sustainable multi-material 3D fabrication route.
Entanglement of Spin Transition and Elastic Interactions: Manipulating the Slow Spin Equilibrium by Guest-Mediated Fine-Tuning Elastic Frustration
Authors: Xue Jin-Peng , Chai Yuqiao , Yang Yu-Ting , Li Xing , Li Bao
Published: September 2024

A comprehensive analysis of the physical and chemical properties using the same family of complexes is crucial for understanding and designing structure-property relationships. However, finding the appropriate system remains challenging. Here, a series of guest-saturated states based on the 2D Hofmann-type framework [FeII(prentrz)2PdII(CN)4]·guest (prentrz = (1E,2E)-3-phenyl-N-(4H-1,2,4-triazol-4-yl)prop-2-en-1-imine, 1·guest) is reported, which exhibit a guest-manipulated slow dynamic effect of spin equilibrium in an incomplete two-step spin-crossover (SCO) process. Using a full-sealed method by modulating the mixing ratios and types of CH3OH, H2O, and D2O, stable maintenance of guest-saturated states allows fine-tuning elastic frustration (ξ) of the framework to realize SCO behaviors in the unexplored region between one-step incomplete (HS0.5LS0.5↔HS) and two-step complete (LS↔HS0.5LS0.5↔HS) processes. A semi-sealed method enables continuous guest molecule loss until the guest-saturated state disappears, transitioning slow spin equilibrium from difficult to overcome to overcome fully. The study demonstrates that guest molecule modulation is more controllable than structural deformation effects on elastic frustration, offering a pathway to discover hidden types of SCO materials and develop new stimulus-responsive materials.
Reduced GABA transmission onto ventral tegmental area dopamine neurons underlies vulnerability to a mouse model of Anorexia Nervosa
Authors: Ducrocq Fabien , Brouwer Eileen , Kooij Karlijn , Wolterink-Donselaar Inge , Drost Lisa , Hak Jaimie , Veendijk Melissa , Luijendijk Mieneke , Meye Frank , Adan Roger
Published: September 2024

Anorexia nervosa (AN) has the highest mortality among psychiatric diseases. Hyperactivity is a persistent symptom and alteration of mesolimbic dopamine transmission has been linked to the development and maintenance of the disease and of hyperactivity. However, whether local mesolimbic neurocircuit plasticity is causally involved remains unclear. Especially the role of local GABA control over dopamine neurons, a powerful regulator of the dopamine system, in an AN context is unresolved. We hypothesize that combining caloric restriction with exercise alters dopamine transmission via GABA disinhibition that, in turn, facilitates the expression of maladaptive behaviors such as hyperactivity. Therefore, we characterized the impact of the activity-based anorexia (ABA) model on the plasticity of the dopamine reward system using ex-vivo electrophysiology coupled with optogenetic manipulations. Ventral tegmental area dopamine (VTADA) neurons displayed a higher firing frequency in ABA-exposed animals compared to control mice. This coincided with reduced GABAergic transmission on VTADA neurons, at least in part attributable to decreased excitability of local VTA GABA (VTAGABA) neurons. Restoring the excitability of VTAGABA neurons via chemogenetic activation rescued mice from starvation, by decreasing running wheel activity. In summary, we found that the anorexic state leads to dysregulation of VTAGABA transmission on VTADA neurons that reinforces maladaptive behaviors such as hyperactivity. We uncovered a new mechanism linked to the disturbed dopamine system in ABA-exposed animals, identifying a hitherto unknown role of decreased local GABAergic control over VTA dopamine neuron output.