bluuebunny/crossref_metadata_2025 huggingface dataset:
From Digital Overload to Trading Zen
Authors: Bhatnagar Mukul , Kumar Pawan , Taneja Sanjay , Sood Kiran , Grima Simon
Published: January 2024

Because of the urgency and high stakes involved in their trades, intraday traders are especially vulnerable to the perils of information overload in today's digital world. This chapter explores the potential benefits of digital detox programmes for intraday traders. The research uses the statistical programme SMart PLS to do a route analysis using primary data gathered via questionnaire. The results show that taking a break from technology may dramatically lower stress levels, which in turn boosts business efficiency. This correlation is moderated by traders' levels of expertise, however, indicating that newcomers to the market might gain the most from digital detox programmes. The last section of the study emphasises the chapter's central thesis, arguing for the inclusion of digital detox measures in training programmes and workplace rules in order to address the chapter's identified practical ramifications for traders, trading businesses, and regulatory agencies.
Cyber Bullying in the Health Professions
Authors: Kaviya G. , Kachhi Zidan
Published: January 2024

This chapter delves into the complex and pressing issue of cyberbullying, highlighting its severity, prevalence, and the unique challenges created by digital communication. It explores the variability in defining and understanding cyberbullying, its impact on both individuals and workplaces, and the intersection between digital and traditional boundaries. The chapter emphasizes the importance of taking proactive measures to address and prevent cyberbullying in order to promote the well-being of individuals and the overall health of organizations. Additionally, this comprehensive chapter takes a closer look at workplace cyberbullying, examining its different forms, psychological effects, impact on productivity, and various strategies for prevention and coping. By emphasizing the need for clear policies, threat assessment teams, and psychological support, the chapter underscores the importance of adopting proactive organizational measures to create a safe and positive work environment.
The New Wave in Business Management
Authors: Kalender Zeynep Tuğçe , Zilka Miroslav
Published: January 2024

Companies use strategic management models more than ever to maintain a competitive edge. One of the major problems is how to create and maintain high performance, thus ensuring long-term profitability and sustainability. The business excellence models (BEMs) provide the definition of basic strategic competencies that will provide sustainable competitive advantage through self-assessment. However, considering today's circumstances, re-evaluation of these models becomes a must. In this study, firstly development of BEMs and their changes over the years are examined. The main purpose of this comprehensive analysis is not only to provide an updated overview of existing studies but above all to emphasize what type of changes are necessary considering new trends. In this respect, models are compared both among their different versions based on criteria weights and with each other based on emerging trends. Then, in accordance with the literature review, collected metadata, and comparisons, new requirements are presented.
Internationalization Strategies of FAANG
Authors: Patil Ameya Anil , Girigosavi Sangram
Published: January 2024

Internationalization is the process of expanding an enterprise's presence in global marketplaces. This chapter talks about internationalization and some internationalization strategies, and then discusses some of the internationalization strategies used by FAANG, comprising Facebook, Apple, Amazon, Netflix, and Google, the five best-performing USA tech stocks. The strategies discussed can serve as lessons for entrepreneurs worldwide desirous of expanding their global footprints, especially in the technology sector. Some of the key internationalization strategies found in this work include localization, acquisitions, innovation, and customer-centricity. The strategies that FAANG companies adopt to expand internationally in this digital era can serve as a model for other businesses. Their outstanding capability to penetrate various marketplaces while maintaining their fundamental values and line of business is illustrative of their adaptability and their focus in the long term.
Navigating Educational Evolution
Authors: Waladi Chaimae , Lamarti Mohammed Sefian
Published: January 2024

In the era of educational transformation, this chapter guides educators as the “competence” model replaces traditional qualifications. It focuses on prioritizing tangible skills, urging a reimagination of instructional methods to meet modern workplace needs. The exploration covers objective curation, learner-centric engagements, technology infusion, and strategic competency evaluation. Real-world examples and case studies enrich the proposal, providing a personalized compass for educators in this paradigm shift and championing exceptional learning outcomes.
Personalized Learning
Authors: El Gazi Safae , Ibrahimi Ahmed
Published: January 2024

Education is going through a profound transformation in today's rapidly evolving digital age to meet the needs of learners who are constantly changing. This shift towards personalization is essential to address the unique learning styles, interests, and paces of individual students. The focus of this chapter is on three key aspects of education that are changing the digital age: personalized learning, educational mobile apps, and personalized assessments. This chapter examines the different aspects of personalized education, demonstrating how they transform learning for future generations. By combining personalized learning, educational mobile apps, and individualized assessments, education can become a truly tailored experience, nurturing the diverse talents and potential of every student.
Adaptive Personalized Randomized Response Method Based on Local Differential Privacy
Authors: Zhang Dongyan , Zhang Lili , Zhang Zhiyong , Zhang Zhongya
Published: January 2024

Aiming at the problem of adopting the same level of privacy protection for sensitive data in the process of data collection and ignoring the difference in privacy protection requirements, the authors propose an adaptive personalized randomized response method based on local differential privacy (LDP-APRR). LDP-APRR determines the sensitive level through the user scoring strategy, introduces the concept of sensitive weights for adaptive allocation of privacy budget, and realizes the personalized privacy protection of sensitive attributes and attribute values. To verify the distorted data availability, LDP-APRR is applied to frequent items mining scenarios and compared with mining associations with secrecy konstraints (MASK), and grouping-based randomization for privacy-preserving frequent pattern mining (GR-PPFM). Results show that the LDP-APRR achieves personalized protection of sensitive attributes and attribute values with user participation, and the maxPrivacy and avgPrivacy are improved by 1.2% and 4.3%, respectively, while the availability of distorted data is guaranteed.
Thematic Analysis of User Experience of Contact Tracing Applications for COVID-19 Using Twitter Data
Authors: Alterkait Mariam A. , Almutarie AlJawhara Owaid , Alduaij Manal Y.
Published: January 2024

This paper aims to explore Kuwaiti users' perspectives and experiences with Shlonik, the mandatory contact tracing application that was used during the COVID-19 pandemic. A sample of 2,450 tweets about users' experiences was collected and thematically analyzed. The analysis used DeLone and McLean's information system success model to explore aspects of the degree to which this app can be judged a “success,” using parameters of system quality and service quality. A novel finding identified by this qualitative study was the significance of themes identified in the analysis such as social privacy (timing, privacy, and female privacy, which are related to the cultural and religious norms of Kuwait) and technical privacy (related to data protection). The research identified significant conflict with cultural and social norms in users' experience of the Shlonik app – factors not normally identified or discussed in existing literature. This research supports a need for improved strategies and designs in future m-government applications in developing countries.
Training medical students in ethics and professionalism: Potential challenges and solutions
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: January 2024

From the global perspective, the medical curricula that is being designed and implemented across medical colleges, place more emphasis on acquisition of knowledge and skills. Ethics and professionalism are indispensable traits in the making of a successful medical doctor. Even though medical ethics has been acknowledged and regarded as an integral component of the medical curriculum, we cannot ignore the presence of a curricular gap. As far as professionalism in medical education is considered, we have to acknowledge that a wide range of challenges exist with reference to its teaching and assessment, including the involvement of stakeholders. To conclude, the training component for medical students on ethics and professionalism has been undermined in multiple settings. However, as these are indispensable aspects in the making of a competent medical professional, we must identify the prevailing challenges and accordingly design our action plan to seamlessly integrate training on ethics and professionalism in the medical curriculum.
Long haul in asymptomatic and mild symptomatic COVID-19 patients: A community-based study in Northern India
Authors: Puri Sonia , Narayanan S. Vishnu , Jain Rajat , Saini Varinder , Malhotra Nitya , Sehgal Alka , Das Subhash
Published: January 2024

Introduction:

COVID-19, is a highly contagious disease caused by Novel Corona Virus SARS-Cov-2. After initial infection, most patients recover completely, but in some patients, symptoms may persist for variable duration. This study was planned to evaluate different persistent symptoms of long COVID among the people of Northern India, who had asymptomatic or mild disease during active infection stage.

Methods:

A cross sectional study was done in Chandigarh, India, during August 2021 to June 2022. A total of 647 recovered COVID-19 patients, who had suffered of COVID almost ≥3 months back were included in the study. A self-designed questionnaire was developed for the survey. Participants were followed up till 3 months.

Results:

Out of 647 subjects enrolled, 27.5% had some post-COVID symptoms. Among symptomatic, 55.1% were males and 44.9% were females. Post-COVID headache was significantly more common in females. Sleep disturbances and history of pain and pressure that spreads to arms were significantly more common among non-smokers. Sleep disturbances and change of appetite were significantly more common among non-alcohol users. Chest discomfort and change of appetite were found to be significantly more common among non-hypertensive subjects. Symptoms of chest discomfort, sleep disturbances, anxiety, feeling of sadness on daily basis and forgetfulness was significantly more common among subjects without underlying heart disease, while weakness among patients with underlying lung disease. Poor concentration was found to be significantly more common among patients without underlying lung disease and that in the age group 26-50 years, followed by 51-75 years and 76-100 years.

Conclusion:

This study attempted to assess the prevalence of post COVID complications among the asymptomatic and mild COVID patients. From the clinical point of view, physicians should be aware of the symptoms, signs, and biomarkers present in patients previously affected by COVID-19 to promptly assess, identify and halt long COVID-19 progression, minimize the risk of chronic effects and to re-establish pre-COVID-19 health.
A descriptive cross-sectional study on perceived barriers and facilitators regarding the use of menstrual cups among medical students in a tertiary care hospital in Puducherry
Authors: Mercy M.
Published: January 2024

Introduction:

Adolescence is the period between 10 and 19 years of life, and about one-fifth of the total female population in the world are in this age group who undergo the basic physiological phenomenon called menstruation. The issues related to menstruation are often neglected by family and community which affects the physical, mental and social functioning of the teenagers. By adopting sustainable menstrual hygienic practices, the major disorder of sexual and reproductive health. The objectives of this study were to determine the prevalence of the usage of menstrual cups among medical students, to assess the knowledge and practice about menstrual cup and to determine the barriers and facilitators regarding the use of menstrual cup.

Methods:

This study was a descriptive cross-sectional study conducted among the female medical students of Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry. The study tool was a Google Form comprising the sociodemographic details of the study participants and the details regarding the usage of menstrual products, especially menstrual cups. This study followed the universal sampling method, and a total of 164 students responded. The responses were downloaded from Microsoft Excel and analyzed using SPSS version 21.

Results:

Out of the total 164 study participants, 53% belonged to the age group of 18–22 years, 46% were in the age group of 23–27 years, and 1% were above the age of 27 years. Of these, 20% were 1st year, 16% were 2nd year, 21% were 3rd year, 29% were 4th year, and 14% were interns. The knowledge prevalence of menstrual cups was 78%. The prevalence of the usage of menstrual cups was 85%.

Conclusion:

Hence, much insight has to be tailored to the advancement in knowledge dissemination regarding sexual and reproductive health. The practice of safe, durable, and sustainable menstrual hygienic products such as menstrual cup has to be encouraged as they are cost effective and generate less waste. All menstruating women should be educated about menstrual cups and should be encouraged to use it.
Effect of supportive supervision on the process of indenting and stock management by senior nursing ward in-charges at a tertiary care hospital in Garhwal region of Uttarakhand, India
Authors: Shukla Mukesh , Nandan Tumul , Rawat Chandra Mohan Singh , Singh Daulat
Published: January 2024

Introduction:

The duties of nursing administration include tasks such as placing orders, conducting regular checks on ward supplies, and ensuring regular updation of the stock register. This study assesses the effect of a supportive supervision strategy on the process of indenting and stock management by senior nursing ward in-charges and the barriers faced by them during the discharge of this duty.

Methods:

A cross-sectional study with mixed-method approach was conducted. Senior nursing officers were administered structured questionnaires and in-depth interviews for the quantitative and qualitative approaches, respectively. Quantitative analysis was done using statistical software and qualitative content analysis was done manually for the audio recorded and transcribed in-depth interviews.

Results:

The availability, legibility, accuracy, completeness, chronology, continuity, timeliness, safety, etc., of records, saw improvements on successive follow-up visits. On analyzing the in-depth interviews, administrative and management issues such as constantly changing personnel, unsystematic handover process, and problems related to supply chain and disposal came up. Work-related issues, such as lack of training, workload pressure, as well as staff-related and personal issues, were also identified.

Conclusion:

Transfers of designated senior nursing ward in-charges should be avoided if possible. In case done, the process of proper charge transfer should be followed. Issues such as the lengthy process of indenting and lack of training of nursing staff should be addressed. Incentivizing such work should be encouraged along with increasing autonomy for handling wards by senior nursing officers. Communication with all the stakeholders should be improved.
Providing trusted COVID-19 sources in social media: Establishing Indonesian Pediatric Society's social media ecosystem
Authors: Sjakti Hikari Ambara , Sambo Catharine Mayung , Mardhani Tiara Annisa P. , Ruslim Saskia Octariza , Atmaja Clara Petrisiela I. , Yanuarso Piprim Basarah , Pulungan Aman Bhakti
Published: January 2024

Introduction:

During the COVID-19 pandemic, social media has become the main platform to find information in every aspect. It is important for professional organizations to develop social media in their field. The Indonesian Pediatric Society (IPS) has distributed information through various social media channels, like Professional Official Website. It is formed to reach various target users, hoping that information will be spread evenly among all Indonesian parents. This study aims to describe how the IPS media ecosystem provides trusted health information, which can help disseminate health information among parents and health practitioners during the pandemic.

Methods:

The study used a descriptive design using IPS social media platforms such as Professional Official Website (idai.or.id), Instagram, Facebook, Twitter, YouTube, Public Official Website (anakindonesiasehat.com), and Telemedicine Mobile Application (PrimaKu).

Results:

The IPS's social media accounts have shown significant growth during the pandemic showing that people are more aggressively seeking information from trusted sources. A public education-related Instagram live footage titled “Drugs and Vitamins for children with COVID-19 during quarantine at home” has become the most demanded material for social media users. This shows that social media is an excellent platform for health promotion.

Conclusion:

IPS, as a professional organization, needs to provide accurate, reliable, and up-to-date information on its social media and should take advantage of this opportunity to disseminate the latest guidelines and educate the public more thoroughly, especially parents, to help them obtain information on children's health.
Crop Growth Prediction using Ensemble KNN-LR Model
Authors: Harshitha Attaluri , Naseeba Beebi , Kumar Rao Narendra , Sathwik Abbaraju Sai , Challa Nagendra Panini
Published: January 2024

Research in agriculture is expanding. Agriculture in particular relies heavily on earth and environmental factors, such as temperature, humidity, and rainfall, to forecast crops. Crop prediction is a crucial problem in agriculture, and machine learning is an emerging study area in this area. Any grower is curious to know how much of a harvest he can anticipate. In the past, producers had control over the selection of the product to be grown, the monitoring of its development, and the timing of its harvest. Today, however, the agricultural community finds it challenging to carry on because of the sudden shifts in the climate. As a result, machine learning techniques have increasingly replaced traditional prediction methods. These techniques have been employed in this research to determine crop production. It is critical to use effective feature selection techniques to transform the raw data into a dataset that is machine learning compatible in order to guarantee that a particular machine learning (ML) model operates with a high degree of accuracy. The accuracy of the model will increase by reducing redundant data and using only data characteristics that are highly pertinent in determining the model's final output. In order to guarantee that only the most important characteristics are included in the model, it is necessary to use optimal feature selection. Our model will become overly complex if we combine every characteristic from the raw data without first examining their function in the model-building process. Additionally, the time and area complexity of the Machine learning model will grow with the inclusion of new characteristics that have little impact on the model's performance. The findings show that compared to the current classification method, an ensemble technique provides higher prediction accuracy.
Redefining Space Commerce: The Move Toward Servitization
Authors: Khan Samir
Published: January 2024

“New Space" is reshaping the economic landscape of the space industry and has
far-reaching implications for technological innovation, business models, and
market dynamics. This change, aligned with the digitalization in the world
economy, has given rise to innovations in the downstream space segment. This
“servitization” of the space industry, essentially, has led to the transition
from selling products like satellites or spacecraft, to selling the services
these products provide. This also connects to applications of various
technologies, like cloud computing, artificial intelligence, and
virtualization.

Redefining Space Commerce: The Move Toward Servitization discusses
the advantages of this shift (e.g., cost reduction, increased access to space
for smaller organizations and countries), as well as the challenges, such as
maintaining safety and security, establishing standardization and regulation,
and managing risks. The implications of this may be far-reaching, affecting not
only the space industry but also related fields, such as defense,
telecommunications, and activity monitoring. This report also explores the
transformative changes happening in the space sector and their impact on
economic evaluation and space policy.

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The freshmen’s attitudes towards using videos in reading class
Authors: Phuong Tran Thanh , Quynh Ngo Nhat Phuong
Published: January 2024

Implementing video clips on enhancing university students’

reading skill have been popular in Vietnam. This study aimed at

exploring the effects of employing video clips in reading

improvement of English-majored freshmen from their perspectives.

What is crucial here is whether applying video clips to teaching and

can boost the learners’ reading performance or not as well as how

profound their upgrade in reading is. For this study, the quantitative

approach as well as accumulating data were applied to investigate

the students’ perceptions regarding the cons occurred when applying

video clips to the development of their reading skill. To collect data

for the study, fifty first-year English majors took part in the online

questionnaire regarding the reading performance after reading

period by video clip assistance. The findings reflect that the majority

of the students had a positive attitude towards utilizing videos in

acquiring the reading skill. As a result, with the implementation of

videos in reading classes, students were motivated to engage in

reading activities. Additionally, teachers are encouraged to make use

of the online video sources to increase the students’ motivation and

engagement in acquiring reading skill.
Extramural English and Vietnamese EFL primary school students’ listening and reading proficiency in Vietnam
Authors: Thi Dang Thi , Thinh Le Van
Published: January 2024

Many studies worldwide have found correlations between

students’ exposure to English outside the classroom and students’

English vocabulary and oral proficiency. However, these studies

have mostly been conducted with ESL (English as a Second

Language) high school students or older students, while primary

school students in EFL (English as a Foreign Language) countries

have not been well documented. The study aimed to (1) investigate

whether there are any correlations between Extramural English (EE)

and listening and reading proficiency of Vietnamese EFL primary

school students, and (2) determine their experience with EE. The

participants were 101 Vietnamese elementary school students. Both

interviews and questionnaires were used to collect information

regarding students’ extramural English outside of the classroom and

their experiences in EE activities. An English proficiency test

including listening and reading was employed to examine students’

listening and reading. Findings showed that there was a correlation

between extramural English and EFL primary students’ listening and

reading proficiency. Most students participated in two main EE

activities: using English game-based learning applications and

surfing the internet. The study suggested different techniques, some

online games, and materials to support learners in acquiring a new

language actively, and teachers could encourage more students to

practice extramural English outside the classroom.
Tư duy thiết kế trong giáo dục an toàn giao thông cho học sinh trung học phổ thông tại Thành phố Hồ Chí Minh
Authors: Anh Trịnh Tú , Hoài Phạm Nguyễn , Toàn Lê Phúc , An Lê Phan Trường , Việt Lê Quốc , Anh Trịnh Thùy
Published: January 2024

Nâng cao kiến thức và kỹ năng về an toàn giao thông thông qua giáo dục là mục tiêu của nhiều quốc gia. Bên cạnh đó, công nghệ thực tế ảo có tiềm năng trong việc tạo ra một môi trường tương tác, hiệu quả và an toàn cho người tham gia học. Do đó, nghiên cứu này áp dụng phương pháp tư duy thiết kế, bao gồm năm bước quan trọng (đồng cảm, xác định vấn đề, tạo ý tưởng, dựng mẫu, và thử nghiệm), vào việc xây dựng môi trường giao thông thực tế ảo, giúp cho học sinh trung học phổ thông tại Thành phố Hồ Chí Minh có một trải nghiêm thực tế liên quan đến lĩnh vực này. Phỏng vấn nhóm đã được thực hiện với 32 học sinh nhằm khảo sát các yếu tố như sự đắm chìm, sự hiện diện và sự tương tác trong môi trường giao thông thực tế ảo. Kết quả cho thấy các em đắm chìm vào môi trường giao thông ảo, cảm thấy được sự tồn tại của mình và tương tác với các yếu tố trong môi trường. Môi trường giao thông thực tế ảo cần được nghiên cứu sâu rộng hơn trong tương lai nhằm đảm bảo tính khả thi trong việc thực hiện, làm nền tảng cho giáo dục an toàn giao thông cho học sinh trung học phổ thông tại Thành phố Hồ Chí Minh.
Quantitative stability estimate for the inverse coefficients problem in linear elasticity
Authors: Meftahi H , Rezgui T
Published: January 2024

In this article we consider the inverse problem of reconstructing piece-wise Lamé coefficients from boundary measurements. We reformulate the inverse problem into a minimization one using a Kohn-Vogelius type functional. We study the stability of the parameters when the jump of the discontinuity is perturbed. Using tools of shape calculus, we give a quantitative stability result for local optimal solution.

Dans cet article, nous considérons le problème inverse de reconstruction des coefficients de Lamé constants par morceaux à partir de mesures au bord. Nous reformulons le problème inverse en un problème de minimisation utilisant une fonctionnelle de type Kohn-Vogelius. Nous étudions la stabilité des paramètres lorsque le saut de la discontinuité est perturbé. En utilisant les outils du calcul de forme, nous donnons un résultat de stabilité quantitative pour une la solution optimale locale.
INOVASI PENDIDIKAN DI BIDANG MANAJEMEN KELAS DALAM PEMBELAJARAN DARING UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA SEKOLAH DASAR
Authors: Riadi Fadhilah Salsabila , Rostika Deti
Published: January 2024

Abstract: The purpose of this study is to examine educational innovations in the field of classroom management in online learning to increase the learning motivation of elementary school students. This research was conducted using qualitative research methods. With research techniques literature studies from various relevant sources. The result of this research is that increasing students' motivation in online learning, it can be done through classroom management to create effective classroom conditions. By applying the principles of classroom management, managing the classroom environment, creating a positive atmosphere in the classroom, applying rules, and establishing good communication with the teacher as a facilitator. The existence of classroom management in achieving effective learning can increase student learning motivation and make learning more focused. In addition, the contribution of parents is also needed in guiding and assisting students during online learning carried out from home.Keywords: classroom management innovation, online learning, learning motivation, elementary school  Abstrak: Maka dari itu tujuan penelitian ini mengkaji perihal inovasi pendidikan di bidang manajemen kelas dalam pembelajaran daring untuk meningkatkan motivasi belajar siswa sekolah dasar. Penelitian ini dilakukan dengan menggunakan metode penelitian kualitatif. Dengan teknik penelitian studi literatur dari berbagai sumber yang relevan. Hasil dari penelitian ini yaitu dalam meningkatkan motivasi belajar siswa dalam pembelajaran daring dapat dilakukan melalui manajemen kelas agar tercipta kondisi kelas yang efektif. Dengan menerapkan prinsip-prinsip manajemen kelas, mengatur lingkungan kelas, menciptakan atmosfer yang positif dalam kelas, menerapkan peraturan, dan terjalin komunikasi yang baik dengan guru sebagai fasilitator. Adanya manajemen kelas dalam mencapai pembelajaran yang efektif dapat meningkatkan motivasi belajar siswa dan menjadikan pembelajaran lebih terarah. Selain itu, diperlukan pula kontribusi orang tua siswa dalam membimbing dan mendampingi siswa selama pembelajaran daring yang dilakukan dari rumah.Kata Kunci: inovasi manajemen kelas, pembelajaran daring, motivasi belajar, sekolah dasar
Клініко-патофізіологіне обґрунтування синдрому взаємного обтяження у постраждалих з бойовою комбінованою термо-механічною травмою та вогнепальними переломами довгих кісток
Authors: Palii I. P.
Published: January 2024

Мета. Проаналізувати особливості змін гомеостазу у постраждалих з бойовою комбінованою термо-механічною травмою (БКТМТ) та науково обґрунтувати оцінку тяжкості цих ушкоджень з подальшим передбаченням розвитку синдрому взаємного обтяження (СВО).

Матеріали та методи. Проведено порівняльне комплексне клінічне обстеження 178 постраждалих, які було розподілено  на 51 постраждалих основної та 127 додаткової клінічної груп із вогнепальним ізольованим переломом стегнової кістки, ізольованими опіками тіла І ст., ІІІ ст., та постраждалих з тяжкою, вкрай тяжкою БКТМТ у яких вогнепальний перелом довгих кісток як провідний компонент комбінувався з опіками тіла.

Результати. У зв'язку з цим ми зробили висновок, що у постраждалих з вкрай тяжкою БКТМТ, коли вогнепальний перелом довгих кісток комбінувались з тяжкими позаскелетними ушкодженнями (опіками), розвиваються специфічні розлади гомеостазу у відповідь на механічну травму у вигляді СВО, який і зумовлює летальний кінець.

Висновки. Найбільш достовірно тяжкість стану постраждалих з БКТМТ відображають такі показники гомеостазу, як разова продуктивність серця, коефіцієнт інтегральної тонічності судин, показник напруженості дихання, показник стабілізації тонусу судин, показник виразності дихально-циркуляторних розладів. Ізольований перелом довгих кісток є тяжким ушкодженням, яке при поєднанні з тяжкими позаскелетними ушкодженнями (опіками) зумовлює СВО.
Вивчення фармакокінетичних показників лікарського засобу під умовною назвою «МІЛР-КРЕМ» методом in Vivo
Authors: Ostaschenko T. M.
Published: January 2024

Вступ. Фармацевтична розробка нового лікарського засобу (ЛЗ) передбачає всебічне вивчення показників, що впливають на фармако-технологічні, біофармацевтичні властивості препарату. Серед біофармацевтичних досліджень особливу увагу звертає дослідження фармакокінетики препарату методами in vitro та in vivo. Метод in vitro моделює вивільнення активних фармацевтичних інгредієнтів (АФІ) через мембрану, яку можна розглянути як штучну біомембрану (шкіру). На підставі цього дослідження можна судити про кінетику хімічної реакції, а також про порядок вивільнення АФІ з основи. Дані процеси можна вивчити методом in vivo, який моделює «програму» вивільнення АФІ в кров або шкіру. Однак прямої кореляції між методами in vitro та in vivo не існує. Тому для нас стало актуальною проведення фармакокінетичних лосліджень методом in vivo.

Метою даного дослідження стало вивчення фармакокінетичних показників розробленого ЛЗ методом in vivo на щурах.

Матеріали та методи дослідження. В ході дослідження нами після вивчення специфічної активності препарату на щурах були відібрані біологічні матеріали – кров та шкіра з м`язовими тканинами. Для цього кров була відібрана з хвостової вени щурів, а тканини – після декапітації тварин. Дослідження фармакокінетики препарату методом in vivo проводили на 5 щурах. Проведення ізолювання та виявлення АФІ проводили на базі кафедри біотехнології, біофізики і аналітичної хімії Національного технічного університету «ХПІ» (м. Харків) під керівництвом д.тех.н., проф. Близнюк О. М. (метод ВЕРХ згідно Договору між НУОЗ імені П. Л. Шупика та «ХПІ») та проф. Давтян Л. Л. (ізолювання речовин з крові та тканин).

Результати. На основі експериментальних даних нами встановлено, що препарат не всмоктується в кров. Отже, препарат є місцевої дії. Для підтвердження нашого припущення щодо місцевої дії препарату нами вивчено концентрацію АФІ в шкіри з м`язовими тканинами при аплікаційному введенні препарату. Для цього 0,1 г подрібненої шкіри із м’язовою тканиною заливали 20мл ацетонітрилу та екстрагували на орбітальному шейкері впродовж 30 хв. Ацетонітрильний екстракт кількісно переносили в мірну колбу (50 мл) та доводили до мітки ацетонітрилом. Отриманий розчин перемішували, фільтрували та досліджували методом ВЕРХ.

Висновки. При аплікаційному способі введення ЛЗ фармакокінетичні параметри залежать від фармацевтичних факторів, зокрема розчинності, способу введення АФІ до основи та самої основи.Фармакокінетичні показники використовуються для оцінки зміни концентрацій АФІ в залежності від часу в специфічній камері, де виявляється терапевтична дія препарату. Отже нами доведено, що терапевтичний ефект ЛЗ пов’язана з його концентрацією в тканинах (препарат місцевої дії).
Desenvolvimento dentário em crianças com Microcefalia: série de casos
Authors: Oliveira Anna Liz Santos , Velame Maria Leticia Menezes , Ramos Maislla Mayara Silva , Bonfim Rita de Cássia Riséio , Pedreira Kaynã Silva , Ismerim Adna Barros , Viana Rita de Cássia Dias , Monteiro Adriano Monteiro D'Almeida , De Freitas Maria da Conceição Andrade
Published: January 2024

O objetivo deste estudo pretendeu descrever a cronologia e sequência de erupção dentária de crianças com microcefalia. Trata-se de um estudo qualitativo transversal observacional do tipo relato de casos clínicos. Foram analisadas 5 crianças, ambos os sexos, 6 a 8 anos de idade, diagnosticadas com microcefalia grave sem síndromes ou outras anomalias craniofaciais relacionadas. Nos exames intrabucais e radiográficos, as crianças apresentaram alterações na sequência de erupção dentária e atraso na erupção dos primeiros molares permanentes.  Fatores como o alto grau de aumento gengival generalizado induzido por biofilme e potencializado pelo uso frequente de fármacos anticonvulsivantes contribuíram para a ocorrência do atraso nas erupções dentárias dos primeiros molares permanentes.
Pengaruh Product Quality, Brand Image dan Promotion terhadap Purchasing Decisions pada Batik Tulis Al Huda Sidoarjo
Authors: Ayubi Mochamad Ayub Al , Sari Dewi Komala
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk, citra merek dan promosi terhadap keputusan pembelian pada Batik Tulis AL Huda Sidoarjo. Penelitian ini merupakan penelitian deskriptif dengan menggunakan metode kuantitatif. Teknik pengambilan data yaitu dengan menyebar kuesioner pada 388 responden yang merupakan konsumen dari Batik Tulis AL Huda. Teknik analisis yang digunakan dalam penelitian ini adalah regresi linier berganda yang menggunakan program SPSS (Statistical Program for Social Science) versi 22 for windows. Hasil penelitian ini menunjukkan bahwa variabel kualitas produk berpengaruh terhadap keputusan pembelian, variabel citra merek berpengaruh terhadap keputusan pembelian, variabel promosi berpengaruh terhadapa keputusan pembelian dan variabel kualitas produk, citra merek dan promosi berpengaruh secara bersama – sama terhadap keputusan pembelian pada Batik Tulis AL Huda.
Does the Index of Child Right Fulfillment Explain the Children’s Wellbeing in Indonesia?
Authors:   Faculty of Economics and Business, Sebelas Maret University, Indonesia, Vebrianna Nanda Restu , Hakim Lukman ,   Faculty of Economics and Business, Sebelas Maret University, Indonesia, Putro Tetuko Rawidyo ,   Faculty of Economics and Business, Sebelas Maret University, Indonesia
Published: January 2024

A safe city for children becomes the evidence of the role and the action of the government to improve children’s well-being. This city also prevents any violence against children by collaborating the roles of the government and the parents. This research reviews the determinant factors of children’s well-being in Indonesia based on the factors of parents’ contributions and government role. This research’s contribution is – to the children’s well-being in Indonesia by fulfilling their rights. The implications of the study are – to determine the index of children’s fulfillment and to explain the children’s well-being seen from the factors of parent and government roles. This research applied multiple linear regression on the panel data from 2018 to 2021 in Indonesia. The research findings included the index of child rights fulfillment in Indonesia could explain the factors of children’s well-being in Indonesia with the collaborated roles from the parents and the government. However, specific attention is important for the government expenditure on various sectors to optimize the children’s well-being. Low realizations for government expenditure were observable in the educational and social well-being sectors.
Problems of systemic connective tissue diseases of childhood in historical perspective
Authors: Kaleda M. I. , Nikishina I. P.
Published: January 2024

The relevance of study systemic connective tissue diseases with juvenile onset for modern medicine is determined by the trend towards their growth in the population, the difficulty of early diagnosis, the rapid development of disability and a poor life prognosis. The article presents the main achievements in the study of this group of diseases in children, with an emphasis on the most significant issues from a practical point of view related to diagnosis, classification, clinical features and modern approaches to treatment.
Do not say or write: “pain syndrome”! You say “pain”!
Authors: Karateev A. E.
Published: January 2024

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Work disability in systemic sclerosis – What is known?
Authors: Klimenko A. A. , Mikheeva E. P. , Shostak N. A. , Demidova N. A.
Published: January 2024

The medical and social significance of systemic sclerosis (SSc) is high. The progressive disease has a significant impact on the functional status, work participation and leads to early disability in patients of working age. The article presents data on the prevalence of work disability in patients with SSc in comparison with other rheumatic diseases, the frequency of separation from work and work transitions due to the problems connected with SSc, the socio-economic burden of SSc in different countries. The article specifies the components of the disease which affect the ability to work, the main approaches to quantify the indicators of working ability, describes the instruments most commonly used for this purpose. The data of various authors on working ability measurement and predictors of work disability in patients with SSc are presented.
Pro-inflammatory activation of monocytes in patients with immunoinflammatory rheumatic diseases
Authors: Bogatyreva A. I. , Gerasimova E. V. , Kirichenko T. V. , Markina Yu. V. , Popkova T. V. , Shalygina M. V. , Tolstik T. V. , Markin A. M. , Orekhov A. N.
Published: January 2024

The pathogenesis of immunoinflammatory rheumatic diseases (IRDs) is based on chronic inflammation, one of the key mechanisms of which may be abnormal activation of macrophages, leading to further disruption of the immune system.

The aim – to evaluate the pro-inflammatory activation of circulating monocytes in patients with IRDs.

Material and methods. The study included 149 participants: 53 patients with rheumatoid arthritis (RA), 45 – with systemic lupus erythematosus (SLE), 34 – with systemic scleroderma (SSc) and 17 participants without IRD, aged 30 to 65 years. Basal and lipolysaccharide (LPS)-stimulated secretion of monocytes was studied in a primary culture of monocytes obtained by immunomagnetic separation from blood. Quantitative assessment of the cytokines tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β) and the monocyte chemoattractant protein-1 (MCP-1) was carried out in the culture fluid by ELISA. Pro-inflammatory activation of monocytes was calculated as the ratio of LPS-stimulated and basal secretions.

Results. It was shown that the basal secretion of all studied cytokines was significantly increased in all groups of patients with IRDs, except for the secretion of IL-1β in the SLE group, compared with the control. LPS-stimulated secretion of TNF-α was increased and MCP-1 was decreased in patients with IRDs compared to the control group; LPS-stimulated IL-1β secretion only in the SSc group was significantly different from the control group. In the RA group, monocyte activation was reduced for all cytokines compared to the control, in the SLE group – for TNF-α and MCP-1, in the SSc group – for MCP-1.

Conclusion. The decrease in pro-inflammatory activation of monocytes in patients with IRDs is due to a high level of basal secretion of cytokines, which can lead to disruption of the adequate immune response in these diseases and is an important link in the pathogenesis of chronic inflammation.
Anti-carbamylated protein antibodies in ACCP-negative and ACCP-positive patients with rheumatoid arthritis
Authors: Dibrov D. A. , Avdeeva A. S. , Diatroptov M. E. , Nasonov E. L.
Published: January 2024

Objective. Assess the level of antibodies to carbamylated proteins (anti-CarP) and analyse the clinical and immunological associations in patients with ACCP-negative and ACCP-positive variants of rheumatoid arthritis.

Materials and methods. 150 patients with a reliable diagnosis of rheumatoid arthritis and 25 patients as healthy controls were included in the study. Depending on ACCP values, two groups of patients were recruited: ACCP-positive (n=75) and ACCP-negative (n=75). RA activity was assessed by the DAS28 (Disease Activity Score 28) index. Determination of antibodies to carbamylated proteins was performed by enzyme-linked immunosorbent assay (BlueGene Biotech, China). Quantitative determination of ACCP in serum was performed by enzyme immunoassay using a commercial reagent kit (AxisShield, UK; upper limit of normal 5.0 U/ml; Orgentec, Germany; upper limit of normal 20.0 U/ml).

Results and discussion. Me for anti-CarP in patients with RA was 126.2 [100.83; 157.41] ng/ml and was statistically significantly higher (p<0.001) than healthy controls 88.89 [70.53; 107.75] ng/ml. Among all patients with RA, 50 (33.3%) were anti-Carp positive, 22 (29.3%) were anti-Carp(+) in the ACCP(+) group, 28 (37.3%) in the ACCP(–) group, and 1 (2%) volunteer from healthy controls (p=0.002). In ROC analysis to assess the diagnostic significance of anti-Carp for RA for all patients with RA, the area under the curve was 0.783±0.047 (95% CI: 0.691–0.874; p<0.001), with a cut-off point of 143 ng/ml, specificity 96%, sensitivity 36.7%.

In the ACCP(+) RA group, the erosion count was statistically significantly higher (p=0.044) in anti-CarP(+) patients than in anti-CarP(–) patients. A weak direct correlation between anti-CarP and DAS28 was found in the ACCP(–) RA group.

Conclusion. We studied the predictive value of anti-CarP as an adjuvant biomarker in ACCP(+) and ACCP(–) subtypes of RA. ACCP(+), anti-CarP(+) patients have a more “erosive” subtype of the disease than ACCP(+), anti-CarP(–) patients. In ACCP(+) patients, anti-CarP helps to identify a more erosive subtype of the disease, and among ACCP(–) patients, it helps to reduce the proportion of seronegative patients. Further studies are needed to determine the optimal standards for the laboratory diagnosis of anti-CarP and to clarify the diagnostic potential of these antibodies as part of the differential diagnosis of arthritis in other rheumatic diseases.
The Association between Urinary Alcohol Metabolites on Hepatitis C Treatment and Response
Authors:   Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA, Issac Aaron Gerard , Wang Yun Han Hannah ,   Emory University School of Public Health, Atlanta, GA, USA, Shah Anand S. ,   Division of Digestive Disease, Joseph Maxwell Cleland Atlanta VA Medical Center, Atlanta, GA, USA, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA, Cartwright Emily ,   Division of Infectious Disease, Joseph Maxwell Cleland Atlanta VA Medical Center, , Atlanta, GA, USA, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Published: January 2024

Background: Direct-acting antiviral (DAA) medications for the treatment of chronic hepatitis C virus (HCV) infection has achieved higher rates of sustained virologic response (SVR) with shorter treatment durations and no alcohol abstinence prerequisite. Previous therapies required alcohol abstinence for at least 6 months. Methods: Our retrospective cohort study in Veterans with chronic HCV infection presenting for care at the Joseph Maxwell Cleland Atlanta VA medical center (AVAMC) between 1/1/2015 – 11/29/2017 examined the relationship between alcohol use, DAA initiation, and SVR. Results: The cohort included 1763 people that were mostly males (97%) with a mean age of 63 years and 70% Black. In multivariate analysis, the odds of receiving DAA were 0.7 (95% CI: 0.674, 0.9; p=0.0013) in those with “detectable” alcohol metabolites compared with those who had “undetectable” alcohol metabolites. The odds of achieving SVR were 0.7 (95% CI: 0.5, 1.0; p=0.0525) in those with “detectable” alcohol metabolites. Overall, 86% of patients who received DAA therapy achieved SVR. Conclusions: Alcohol use categorized using urine alcohol metabolite testing, during the study period was associated with a significantly lower odds of receiving DAA therapy but had no statistical significance on the odds of achieving SVR. While patients with chronic hepatitis C should be counseled on the risks of alcohol use, it is not associated with lower likelihood of achieving SVR and should not preclude the initiation of DAA therapy
Varicocelectomy in Male Subfertility Treatment: ‘‘Updated’’ Indications for Surgery
Authors:   Department of Urology, Tashkent Medical Academy. 2, Farobiy str. 100109, Tashkent, Uzbekistan, B Shomarufov Azizbek
Published: January 2024

We analyzed the recent literature data on varicocelectomy in treatment men from infertile couples. There are still a lot of unresolved issues that require clarification. It is still unclear the exact pathogenesis of testicular malfunction in some men with varicocele. Recent European and American urological guidelines recommend varicocele repair in men from infertile couples with “abnormal” semen parameters. Although, according to the 6th ed. of WHO laboratory manual for the examination and processing of human semen it is not clear the cut-off values between normal and abnormal semen parameters. Also, still unclear why approximately third part of patients do not experience any improvement after varicocele repair. According to the recent data analysis, total progressively motile sperm count (TMSC) and sperm concentration can be the significant predictors of semen improvement and pregnancy after varicocele repair. However, it should be remarked that the mean quality of existed data from low to moderate. All mentioned issues indicate the necessity of further large-scale multicenter randomized clinical trials.