bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-Wide Analysis of Ascorbic Acid Metabolism Related Genes in Fragaria × ananassa and Its Expression Pattern Analysis in Strawberry Fruits
Authors: Liu Huabo , Wei Lingzhi , Ni Yang , Chang Linlin , Dong Jing , Zhong Chuanfei , Sun Rui , Li Shuangtao , Xiong Rong , Wang Guixia , Sun Jian , Zhang Yuntao , Gao Yongshun
Published: July 2022

Ascorbic acid (AsA) is an important antioxidant for scavenging reactive oxygen species and it is essential for human health. Strawberry (Fragaria × ananassa) fruits are rich in AsA. In recent years, strawberry has been regarded as a model for non-climacteric fruit ripening. However, in contrast to climacteric fruits, such as tomato, the regulatory mechanism of AsA accumulation in strawberry fruits remains largely unknown. In this study, we first identified 125 AsA metabolism-related genes from the cultivated strawberry “Camarosa” genome. The expression pattern analysis using an available RNA-seq data showed that the AsA biosynthetic-related genes in the D-mannose/L-galactose pathway were downregulated remarkably during fruit ripening which was opposite to the increasing AsA content in fruits. The D-galacturonate reductase gene (GalUR) in the D-Galacturonic acid pathway was extremely upregulated in strawberry receptacles during fruit ripening. The FaGalUR gene above belongs to the aldo-keto reductases (AKR) superfamily and has been proposed to participate in AsA biosynthesis in strawberry fruits. To explore whether there are other genes in the AKR superfamily involved in regulating AsA accumulation during strawberry fruit ripening, we further implemented a genome-wide analysis of the AKR superfamily using the octoploid strawberry genome. A total of 80 FaAKR genes were identified from the genome and divided into 20 subgroups based on phylogenetic analysis. These FaAKR genes were unevenly distributed on 23 chromosomes. Among them, nine genes showed increased expression in receptacles as the fruit ripened, and notably, FaAKR23 was the most dramatically upregulated FaAKR gene in receptacles. Compared with fruits at green stage, its expression level increased by 142-fold at red stage. The qRT-PCR results supported that the expression of FaAKR23 was increased significantly during fruit ripening. In particular, the FaAKR23 was the only FaAKR gene that was significantly upregulated by abscisic acid (ABA) and suppressed by nordihydroguaiaretic acid (NDGA, an ABA biosynthesis blocker), indicating FaAKR23 might play important roles in ABA-mediated strawberry fruit ripening. In a word, our study provides useful information on the AsA metabolism during strawberry fruit ripening and will help understand the mechanism of AsA accumulation in strawberry fruits.
The Impact of Family Functioning on College Students’ Loneliness: Chain-Mediating Effects of Core Self-Evaluation and Problematic Mobile Phone Use
Authors: Qian Ling , Wang Die , Jiang Min , Wu Wei , Ni Congying
Published: July 2022

Purpose

To examine the influence of family functioning on college students’ loneliness and the mediating effects of core self-evaluation and problematic mobile phone use.

Methods

Family Function Scale, Core Self-evaluation Scale, Problem Mobile Phone Use Scale, and Loneliness Scale were used to investigate 8,524 college students.

Results

(1) Family functioning positively predicted core self-evaluation (β = 0.43, p < 0.001) and negatively predicted loneliness (β = −0.21, p < 0.001); (2) Core self-evaluation negatively predicted problematic mobile phone use and loneliness (β = −0.34, p < 0.001; β = −0.50, p < 0.001); (3) Problematic mobile phone use significantly positively predicted loneliness (β = 0.05, p < 0.001); (4) Core self-evaluation and problematic mobile phone use showed a significant chain-mediation effect between family functioning and loneliness (β = −0.01, p < 0.001).

Conclusion

The results are helpful to comprehend the producing mechanism of loneliness and provide a theoretical basis for the intervention of loneliness.
Factors Predicting the Quality of Life of University Students in Japan Amidst COVID-19: A Cross-Sectional Study
Authors: Hirano Yuko O. , Uchino Risako , Tanaka Sae , Doi Mutsumi , Aramaki Koichi
Published: July 2022

Owing to the COVID-19 pandemic, classes and club activities in Japanese universities have been canceled; this may increase students' perceived stress and adversely affect their quality of life. This study investigated the factors that influence Japanese university students' quality of life during the pandemic. An online questionnaire collating data related to demographic characteristics, the perceived stress scale (PSS), sense of coherence (SOC), number of social supports, and quality of life (Short Form Health Survey; SF-8) was distributed to university students. Participants were divided into two groups: those who entered university before (seniors) and after (juniors) the onset of the pandemic. Their scores on the two sub-domains (physical and mental) of the SF-8 were evaluated. Multiple regression analysis was performed to identify factors associated with the composite mental summary of the SF-8. Regression analysis indicated that the predictor model of the composite mental summary differed between juniors and seniors. Among seniors, the composite mental summary was significantly indicated by the composite physical summary (β = 0.549, p < 0.0001) and PSS (β = 0.422, p < 0.0001). Among juniors, it was significantly indicated by the composite physical summary (β = 0.531, p < 0.0001), PSS (β = 0.390, p < 0.0001), and number of social supports (β = −0.148, p = 0.006). The factors associated with quality of life differed between seniors and juniors. Universities must provide opportunities for students to find more friends, especially for juniors who have limited socialization opportunities owing to the pandemic.
Governing Antimicrobial Resistance (AMR) in a Changing Climate: A Participatory Scenario Planning Approach Applied to Sweden in 2050
Authors: Lambraki Irene Anna , Cousins Melanie , Graells Tiscar , Léger Anaïs , Abdelrahman Sara , Desbois Andrew P. , Gallagher Rose , Staaf Larsson Birgitta , Mattson Bengt , Henriksson Patrik , Troell Max , Søgaard Jørgensen Peter , Wernli Didier , Carson Carolee Anne , Parmley Elizabeth Jane , Majowicz Shannon Elizabeth
Published: July 2022

Background

Antimicrobial resistance (AMR) is a growing global crisis with long-term and unpredictable health, social and economic impacts, with which climate change is likely to interact. Understanding how to govern AMR amidst evolving climatic changes is critical. Scenario planning offers a suitable approach. By envisioning alternative futures, stakeholders more effectively can identify consequences, anticipate problems, and better determine how to intervene. This study explored future worlds and actions that may successfully address AMR in a changing climate in a high-income country, using Sweden as the case.

Methods

We conducted online scenario-building workshops and interviews with eight experts who explored: (1) how promising interventions (taxation of antimicrobials at point of sale, and infection prevention measures) could each combat AMR in 2050 in Sweden given our changing climate; and (2) actions to take starting in 2030 to ensure success in 2050. Transcripts were thematically analyzed to produce a narrative of participant validated alternative futures.

Results

Recognizing AMR to be a global problem requiring global solutions, participants looked beyond Sweden to construct three alternative futures: (1) “Tax Burn Out” revealed taxation of antimicrobials as a low-impact intervention that creates inequities and thus would fail to address AMR without other interventions, such as infection prevention measures. (2) “Addressing the Basics” identified infection prevention measures as highly impactful at containing AMR in 2050 because they would contribute to achieving the Sustainable Development Goals (SDGs), which would be essential to tackling inequities underpinning AMR and climate change, and help to stabilize climate-induced mass migration and conflicts; and (3) ”Siloed Nations” described a movement toward nationalism and protectionism that would derail the “Addressing the Basics” scenario, threatening health and wellbeing of all. Several urgent actions were identified to combat AMR long-term regardless which future un-folds, such as global collaboration, and a holistic approach where AMR and climate change are addressed as interlinked issues.

Conclusion

Our participatory scenario planning approach enabled participants from different sectors to create shared future visions and identify urgent actions to take that hinge on global collaboration, addressing AMR and climate change together, and achieving the SDGs to combat AMR under a changing climate.
Utilizing Baidu Index to Investigate Seasonality, Spatial Distribution and Public Attention of Dry Eye Diseases in Chinese Mainland
Authors: Yu Haozhe , Zeng Weizhen , Zhang Mengyao , Zhao Gezheng , Wu Wenyu , Feng Yun
Published: July 2022

Purpose

To explore the characteristics of spatial-temporal prevalence and public attention of dry eye diseases (DED) through Baidu Index (BI) based on infodemiology method.

Methods

The data about BI of DED were collected from Baidu search engine using “Dry eye diseases” as keyword. The spatial and temporal distribution of DED were analyzed through timeseries data decomposition as well as spatial autocorrelation and hotspot detection of BI about DED. The most popular related words and demographic characteristics were recorded to determine the public attention of DED.

Results

The trends of BI about DED in Chinese mainland had gradually increased over time with a rapid increase from 2012 to 2014 and in 2018. The results of timeseries decomposition indicated that there was seasonality in the distribution of BI about DED with the peak in winter, especially in northern regions. The geographic distribution demonstrated the search activities of DED was highest in the east of Chinese mainland while lowest in the west. The vast majority of people searching for DED were teenagers (20–29 years), with a predominance of females. Glaucoma, keratitis and conjunctivitis were the diseases most often confused with DED, and the artificial tears were the most common treatment for DED in Chinese mainland according to the BI about DED.

Conclusions

The analysis revealed the seasonality, geographic hotspots and public concern of DED through BI in Chinese mainland, which provided new insights into the epidemiology of DED.
Effect of Rural-Urban Migration on Age at Marriage Among Adolescent Girls in Bangladesh
Authors: Antu Jannatul Ferdous , Parvin Kausar , Sujan Hasan Mahmud , Mamun Mahfuz Al , Naved Ruchira Tabassum
Published: July 2022

Objectives

Bangladesh reports one of the highest rates of child marriage (CM) (59%) in the world and the highest rate within South Asia. Age at marriage of girls is a critical human rights and developmental issue in Bangladesh. Migration has been documented to be positively associated with age at marriage. Bangladesh experiences one of the highest rates of rural to urban migration in the world. An increase in rural-urban migration of adolescent girls has been observed over the last few decades in Bangladesh with the expansion of employment opportunities particularly in the ready-made garment industry (RMG). This analysis explores the effect of migration on age at marriage and CM among adolescent girls living in urban slums of Dhaka.

Methods

The sample was selected from icddr,b's Urban Health and Demographic Surveillance System (UHDSS) and comprises of never-married adolescent girls aged 15–19, who migrated in from rural Bangladesh to slums in and around Dhaka during 2015–2019. These in-migrants were matched with their rural counterparts from icddr,b's Matlab HDSS (MHDSS), using one to one nearest neighbor matching with caliper 0.1 using propensity score matching (PSM) method. The sample derived included a total of 2,700 never-married adolescent girls from Dhaka and Matlab. The association between migration and age at first marriage was estimated using a linear regression model and the effect of migration on CM was explored using logistic regression analyses.

Results

The in-migrants perfectly matched with their rural peers in terms of age, household wealth and religion. However, their income earning status was hugely different. Urban migrants had significantly higher age at marriage than the rural non-migrants for both 15–19 (Coefficient, 1.77; 95% CI, 1.07–2.46) and 20–24 years age group (Coefficient, 2.87; 95% CI, 2.18–3.55). The migrant girls aged 20–24 years were 71% (aOR, 0.29; 95% CI, 0.12–0.69) less likely to get married before CM age bar in Bangladesh compared to their rural counterparts.

Conclusion

Migration has a positive effect on delaying marriage and reducing CM among adolescent girls. Findings from this study suggest that CM can be reduced by creating educational and economic opportunities for females.
Triple-Negative Breast Cancer Analysis Based on Metabolic Gene Classification and Immunotherapy
Authors: Zhou Yu , Che Yingqi , Fu Zhongze , Zhang Henan , Wu Huiyu
Published: July 2022

Triple negative breast cancer (TNBC) has negative expression of ER, PR and HER-2. TNBC shows high histological grade and positive rate of lymph node metastasis, easy recurrence and distant metastasis. Molecular typing based on metabolic genes can reflect deeper characteristics of breast cancer and provide support for prognostic evaluation and individualized treatment. Metabolic subtypes of TNBC samples based on metabolic genes were determined by consensus clustering. CIBERSORT method was applied to evaluate the score distribution and differential expression of 22 immune cells in the TNBC samples. Linear discriminant analysis (LDA) established a subtype classification feature index. Kaplan-Meier (KM) and receiver operating characteristic (ROC) curves were generated to validate the performance of prognostic metabolic subtypes in different datasets. Finally, we used weighted correlation network analysis (WGCNA) to cluster the TCGA expression profile dataset and screen the co-expression modules of metabolic genes. Consensus clustering of the TCGA cohort/dataset obtained three metabolic subtypes (MC1, MC2, and MC3). The ROC analysis showed a high prognostic performance of the three clusters in different datasets. Specifically, MC1 had the optimal prognosis, MC3 had a poor prognosis, and the three metabolic subtypes had different prognosis. Consistently, the immune characteristic index established based on metabolic subtypes demonstrated that compared with the other two subtypes, MC1 had a higher IFNγ score, T cell lytic activity and lower angiogenesis score, T cell dysfunction and rejection score. TIDE analysis showed that MC1 patients were more likely to benefit from immunotherapy. MC1 patients were more sensitive to immune checkpoint inhibitors and traditional chemotherapy drugs Cisplatin, Paclitaxel, Embelin, and Sorafenib. Multiclass AUC based on RNASeq and GSE datasets were 0.85 and 0.85, respectively. Finally, based on co-expression network analysis, we screened 7 potential gene markers related to metabolic characteristic index, of which CLCA2, REEP6, SPDEF, and CRAT can be used to indicate breast cancer prognosis. Molecular classification related to TNBC metabolism was of great significance for comprehensive understanding of the molecular pathological characteristics of TNBC, contributing to the exploration of reliable markers for early diagnosis of TNBC and predicting metastasis and recurrence, improvement of the TNBC staging system, guiding individualized treatment.
Community Case Study: The Role of Live-Interactive Learning Network in Addressing Community Wide Information Needs Through Show-Me COVID-19 ECHO
Authors: Becevic Mirna , Warne-Griggs Melissa , Wallach Emmanuelle , Edison Karen , Mutrux Rachel , McElroy Jane A. , Hsu Albert , Shyu Chi-Ren , Trotman Robin , Hoffman Kimberly
Published: July 2022

After the COVID-19 pandemic reached Missouri, the Show-Me ECHO (Extension for Community Healthcare Outcomes) project initiated COVID-19 ECHO virtual knowledge-sharing networking sessions. These live-interactive weekly sessions inform participants about up-to-date evidence-based recommendations and guidelines through expert didactic lectures followed by real-life case discussions. We conducted a qualitative analysis of pre-session surveys and questions asked during sessions to learn about information needs of community members during first months of public health emergency. This was a pilot project using qualitative analysis of registration questions regarding anticipated COVID-19 community information needs, and participants' questions asked during sessions collected from March 23 until May 4, 2020. We also analyzed participants' satisfaction surveys collected in December 2020. A total of 761 unique participants attended COVID-19 ECHO during the study period. Survey was completed by 692 respondents. Participants asked 315 questions resulting in 797 identified community information needs. Five thematic categories were recognized: patient care, information seeking, minimizing exposure, financial themes, and general comments. Most attendees rated content quality, logistics, and technical operations as good or excellent on a five-point Likert scale. The COVID-19 ECHO model was responsive to the needs of participants by sharing and discussing up-to-date recommendations and guidelines regarding COVID-19. Sessions were well-attended, and the didactic presenters were invited to deliver same or similar presentations at Boone County Medical Society (BCMS) weekly seminars, suggesting the value of the project to healthcare providers and other community members caring for or working with the most vulnerable populations.
An Occupational Safety and Health Perspective on Human in Control and AI
Authors: Niehaus Susanne , Hartwig Matthias , Rosen Patricia H. , Wischniewski Sascha
Published: July 2022

The continuous and rapid development of AI-based systems comes along with an increase in automation of tasks and, therewith, a qualitative shift in opportunities and challenges for occupational safety and health. A fundamental aspect of humane working conditions is the ability to exert influence over different aspects of one's own work. Consequently, stakeholders contribute to the prospect of maintaining the workers' autonomy albeit increasing automation and summarize this aspiration with the human in control principle. Job control has been part of multiple theories and models within the field of occupational psychology. However, most of the models do not include specific technical considerations nor focus on task but rather on job level. That is, they are possibly not able to fully explain specific changes regarding the digitalization of tasks. According to the results of a large-scale study on German workers (DiWaBe), this seems to be the case to some extend: the influence of varying degrees of automation, moderated by perceived autonomy, on workers' wellbeing was not consistent. However, automation is a double-edged sword: on a high level, it can be reversely related to the workers' job control while highly autonomous and reliable systems can also create opportunities for more flexible, impactful and diverse working tasks. Consequently, automation can foster and decrease the factor of job control. Models about the optimal level of automation aim to give guidelines on how the former can be achieved. The results of the DiWaBe study indicate that automation in occupational practice does not always happen in line with these models. Instead, a substantial part of automation happens at the decision-making level, while executive actions remain with the human. From an occupational safety and health perspective, it is therefore crucial to closely monitor and anticipate the implementation of AI in working systems. Constellations where employees are too controlled by technology and are left with a high degree of demands and very limited resources should be avoided. Instead, it would be favorable to use AI as an assistance tool for the employees, helping them to gather and process information and assisting them in decision-making.
A Remotely Delivered Progressive Walking Intervention for Adults With Persistent Symptoms of a Mild Traumatic Brain Injury: Feasibility and Exploration of Its Impact
Authors: Alarie Christophe , Gagnon Isabelle , Guise Elaine de , McKerral Michelle , Kersalé Marietta , Hoog Béatrice van het , Swaine Bonnie
Published: July 2022

Introduction

Persistent post-concussion symptoms following a mild traumatic brain injury (mTBI) can impact function and participation of adults. Physical activity is recommended to reduce symptoms and foster return to normal activities. Adults with a mTBI may have personal factors or experience accessibility issues restricting physical activity. Walking is a physical activity accessible to most that could be delivered remotely.

Objectives

Determine the feasibility, safety, and acceptability of a remotely delivered progressive walking intervention designed for adults with persistent mTBI symptoms and explore its effects on health-related outcomes.

Methodology

This feasibility study using a single-group pre-post mixed methods convergent parallel design was conducted remotely. Adults aged 18–65 years with a mTBI reporting persistent symptoms for ≥3 months were recruited. The 8-week remote progressive walking intervention aimed to increase the weekly number of steps walked by 40% based on a 1-week baseline measured by a Fitbit Inspire 2 activity monitor. Feasibility measures were about the intervention, its remote delivery, safety, and acceptability. Health-related outcomes were post-concussion symptoms, kinesiophobia, mood, sleep, fatigue, and quality of life. Semi-structured exit interviews were recorded and transcribed verbatim. Quantitative and qualitative data were analyzed separately, and results merged, compared, and contrasted. Descriptive statistics and paired samplest-tests were used. The qualitative analyses followed an iterative content analysis approach using reflexivity and triangulation of sources.

Results

Twenty adults (16 women) aged 42.5 ± 11.51 years with persisting symptoms for 9.25 ± 6.43 months participated, adhered to 94.38% of sessions, completed the intervention, and found it to be feasible, safe and acceptable. Participants increased weekly total number of steps walked (change = 14,886 ± 18,283;t= 3.55,p= 0.002). Severity of post-concussion symptoms (change = −6.42 ± 10.69;t= −2.62,p= 0.018), kinesiophobia (change = −5 ± 6.86;t= 3.18,p= 0.005), anxiety (change = −1.53 ± 3.01;t= −2.21,p= 0.04), and fatigue (change = −10.21 ± 10.20;t= −4.37,p< 0.001) were reduced, whilst quality of life improved (change = 10.58 ± 13.35;t= 3.46,p= 0.003). Participants' perceptions corroborate most quantitative results; they felt improved self-efficacy about physical activity and provided five key recommendations.

Discussion

This study demonstrates the feasibility, safety, and acceptability of the remote 8-week progressive walking intervention, a promising approach to reduce persisting symptoms, improve physical activity level health-related outcomes and quality of life of adults with persistent post-concussion symptoms following a mTBI.
Approaches to STI Prevention and Control in a Highly Decentralized State: An Integrative Review
Authors: Gómez Castellá Javier , Díaz Franco Asunción , Polo Rodríguez Rosa , del Amo Valero Julia
Published: July 2022

The Spanish health system is highly decentralized and Autonomous Regions (AR) are responsible for managing and implementing the National Strategic Plan for Prevention and Control of HIV and other Sexually Transmitted Infections (STI) (2013–2020) via autonomous plans adapted to the characteristics of each region. The aim of this study is to report on actions taken to specifically address STI prevention and control in the autonomous plans within the mainframe of the National Strategic Plan. An integrative review was performed to analyse the health plans and HIV/STI plans of the Spanish AR during the period of validity of the current National Strategic Plan; 2013–2020. Plans were selected attending to specificity and whether strategies were in force during the year 2020. Our gatherings show that plans are largely focused to HIV prevention and control and, to a lesser extent, to STI prevention. The analysis on pre-existing resources for care of STI varied by region, and epidemiological surveillance systems for STI notification were not completely adopted by all of them. Particularly noteworthy are information campaigns, pre- and post-exposure prophylaxis for HIV, and prevention activities in community settings. The remarkable lack of studies concerning STI resources and investment in Spain highlights the necessity of consensus-based tools for evaluation and future planning of STI prevention and control measures. The high degree of heterogeneity among plans for prevention of HIV infection and STIs also points out a high number of different areas for improvement in the development of new AR plans in HIV/STI.
Impact of Dysmenorrhea on Academic Performance Among Haramaya University Undergraduate Regular Students, Eastern Ethiopia
Authors: Mesele Tiruye Tilahun , Ayalew Hiwotie Getaneh , Syoum Asmra Tesfahun , Antehneh Tazeb Alemu
Published: July 2022

Background:

Dysmenorrhea is the most common gynecological problem among students. The disease affects students' academic performance, although studies carried out in Ethiopia primarily focused on the prevalence aspects rather than the impacts of dysmenorrhea on academic performance and its associated factors. Therefore, this study focused on the prevalence of the impact of dysmenorrhea on academic performance and its associated factors among undergraduate female students of Haramaya University in eastern Ethiopia.

Methods

A cross-sectional study design was conducted from February to March 2020. A multistage random sampling technique was applied and a total of 356 students were included in the study. To select students, simple random sampling was used and the sample size was proportionally allocated with respect to the total number of each selected department. A semi-structured and a pre-tested self-administered questionnaire were used. The descriptive result was presented as a proportion whereas the analytic part was presented with an adjusted odds ratio.

Result

The prevalence of the impact of dysmenorrhea on academic performance was 266 [(74.7%):95%CI (70.0, 79.5%)]. Premenstrual syndrome [AOR = 4.86:95%CI (2.13, 11.06)], early menarche [AOR = 4.89:95%CI (2.03, 11.77)], moderate/severe dysmenorrhea pain intensity [AOR = 8.53:95%CI (4.45, 16.39)], and students monthly pocket money <150ETB [AOR = 3.91:95%CI (1.48, 10.29)] were significantly associated with the occurrence of the impact of dysmenorrhea on academic performance. The most common impacts were difficulty in studying followed by loss of concentration in the class.

Conclusion and Recommendation

There was a high prevalence of impact of dysmenorrhea on academic performance among undergraduate female students of the Haramaya University. Awareness should be created among Haramaya university authorities and teachers about the academic performance impact of premenstrual syndrome and dysmenorrhea pain intensity to provide psychological and academic guidance, and managing mechanisms for the affected students. Haramaya University should also establish medical care for the affected students.
Bayesian Nonparametric Learning and Knowledge Transfer for Object Tracking Under Unknown Time-Varying Conditions
Authors: Alotaibi Omar , Papandreou-Suppappola Antonia
Published: July 2022

We consider the problem of a primary source tracking a moving object under time-varying and unknown noise conditions. We propose two methods that integrate sequential Bayesian filtering with transfer learning to improve tracking performance. Within the transfer learning framework, multiple sources are assumed to perform the same tracking task as the primary source but under different noise conditions. The first method uses Gaussian mixtures to model the measurement distribution, assuming that the measurement noise intensity at the learning sources is fixed and known a priori and the learning and primary sources are simultaneously tracking the same source. The second tracking method uses Dirichlet process mixtures to model noise parameters, assuming that the learning source measurement noise intensity is unknown. As we demonstrate, the use of Bayesian nonparametric learning does not require all sources to track the same object. The learned information can be stored and transferred to the primary source when needed. Using simulations for both high- and low-signal-to-noise ratio conditions, we demonstrate the improved primary tracking performance as the number of learning sources increases.
How Does the Starting Order in the First and Second Run Affect the Final Rank in the FIS World Cup Giant Slalom?
Authors: Björklund Glenn , Swarén Mikael
Published: July 2022

The aim of this study was to determine the impact of runs 1 and 2 on overall rank in Giant Slalom. Data from 15 seasons (2005/2006–2019/2020) including and unique starts for women (n = 2,294) and men (n = 2,328) were analyzed. Skiers were grouped based on final ranks 1–3 (G3), 4–10 (G10), and 11–20 (G20) and separately analyzed for women and men. A Wilcoxon-signed rank test was used for comparisons between runs 1 and 2, while a multi-nominal logistic regression was used to identify odds ratios (OR) associated with group rank. Women had similar run times for runs 1 and 2 (p = 0.734), while men had faster times on run 2 (p < 0.001). The strongest association to G3 was during run 1 for run time (men: OR 1.06–1.12; women: OR 1.06–1.11, all p < 0.01) and gate-to-gate times (men: OR 33–475; women: OR 81–2,301, all p < 0.001). Overall, this study demonstrates the importance of a fast first run for improving the final ranking group and the need to increase the tempo going from the first to the second run for men.
The Comparative Effect of Different Timings of Whole Body Cryotherapy Treatment With Cold Water Immersion for Post-Exercise Recovery
Authors: Haq Adnan , Ribbans William J. , Hohenauer Erich , Baross Anthony W.
Published: July 2022

Despite several established benefits of Whole Body Cryotherapy (WBC) for post-exercise recovery, there is a scarcity of research which has identified the optimum WBC protocol for this purpose. This study investigated the influence of WBC treatment timing on physiological and functional responses following a downhill running bout. An additional purpose was to compare such responses with those following cold water immersion (CWI), since there is no clear consensus as to which cold modality is more effective for supporting athletic recovery. Thirty-three male participants (mean ± SD age 37.0 ± 13.3 years, height 1.76 ± 0.07 m, body mass 79.5 ± 13.7 kg) completed a 30 min downhill run (15% gradient) at 60% VO2 max and were then allocated into one of four recovery groups: WBC1 (n = 9) and WBC4 (n = 8) underwent cryotherapy (3 min, −120°C) 1 and 4 h post-run, respectively; CWI (n = 8) participants were immersed in cold water (10 min, 15°C) up to the waist 1 h post-run and control (CON, n = 8) participants passively recovered in a controlled environment (20°C). Maximal isometric leg muscle torque was assessed pre and 24 h post-run. Blood creatine kinase (CK), muscle soreness, femoral artery blood flow, plasma IL-6 and sleep were also assessed pre and post-treatment. There were significant decreases in muscle torque for WBC4 (10.9%, p = 0.04) and CON (11.3% p = 0.00) and no significant decreases for WBC1 (5.6%, p = 0.06) and CWI (5.1%, p = 0.15). There were no significant differences between groups in muscle soreness, CK, IL-6 or sleep. Femoral artery blood flow significantly decreased in CWI (p = 0.02), but did not differ in other groups. WBC treatments within an hour may be preferable for muscle strength recovery compared to delayed treatments; however WBC appears to be no more effective than CWI. Neither cold intervention had an impact on inflammation or sleep.
Primary Brainstem Lymphoma: A Population-Based Study
Authors: Chen Junyu , Cen Bo , Hu Fei , Qiu Yong , Xiao Guomin , Zhou Junge , Ma Xiujian , Zhang Fangcheng
Published: July 2022

Background

Primary brainstem lymphoma (PBSL) is rare and malignant. An understanding of this disease is lacking. We aimed to characterize clinical features, estimate survival, and explore survival-related factors of PBSL.

Methods

Patients with a histological diagnosis of primary lymphoma in the brainstem (C71.7) from 1975 to 2016 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) program. Log-rank tests and univariate and multivariate Cox proportional hazard analyses were used to identify survival-related factors.

Results

PBSL constituted 2.7% of brainstem malignancies. The median age of the PBSL patients was 59.5 years. Diffuse large B cell lymphoma (n = 49, 84.5%) was the most prevalent histology among the 58 cases with reported specific lymphoma subtype. The majority of PBSLs were localized (n = 46, 52.3%), at low Ann Arbor Stage (I/II, n = 63, 70.5%), and presented as a single primary (n = 71, 80.7%). Chemotherapy was applied in 50 (56.8%) cases. Three-year overall survival (OS) and disease-specific survival (DSS) rates were 42.7% and 53.5%, respectively. Multivariate analyses showed that independent predictive/prognostic factors for OS were age (P = 0.004), tumor number (P = 0.029), and chemotherapy (P = 0.001); DSS-related factors only included age (P = 0.014) and chemotherapy (P = 0.008).

Conclusions

We estimated survival rates for PBSL patients. Factors associated with OS and DSS were also identified. Our findings addressed the importance of chemotherapy in treating PBSL patients.
Unicompartmental Knee Arthroplasty for Knee Osteoarthritis With the Pellegrini–Stieda Lesion: A Case Report
Authors: Wang Qiuyuan , Guo Wanshou , Shi Zhencai , Wang Weiguo , Zhang Qidong
Published: July 2022

Pellegrini–Stieda lesion is described as ossification on the origin of medial collateral ligament. We present a case of end-stage knee osteoarthritis with the Pellegrini–Stieda lesion treated by unicompartmental knee arthroplasty (UKA). During the postoperative follow-up, an interesting change occurred such that the ossification lesion disappeared gradually and did not relapse. It is supposed that the disappearance was caused by UKA changing the abnormal biomechanics of the varus osteoarthritic knee.
Undifferentiated Pleomorphic Sarcoma of the Duodenal Papilla: A Rare Case and Worth Discussing History
Authors: Wang Jianlong , Liu Bin , Hou Jiachao , Li Tao
Published: July 2022

Background

Undifferentiated pleomorphic sarcoma (UPS) is a malignant tumor that originates in the mesenchymal tissue and is common in the extremities and retroperitoneum. Primary UPS of the duodenal papilla is rare and a distinct clinical entity.

Case presentation

In this report, a 48-year-old Chinese man was admitted to our hospital with symptoms of melena. The patient underwent choledochectomy and choledochaljejunostomy for obstructive jaundice 8 years before admission. Endoscopic examination after admission confirmed a mass located at the duodenal papilla. Then, the duodenal papilla and tumor resection were performed, and the histopathology report confirmed the diagnosis of UPS. The patient refused further treatment and died 2 months later due to local recurrence and intrahepatic metastasis.

Conclusions

It is rare that the mass in the duodenal papilla is diagnosed as UPS. The unpredicted behavior of these tumors warrants a careful plan considering their indolent nature and possible recurrence and metastasis. The prognosis was poor despite the early complete resection.
RETRACTED: Correlation Analysis Between Required Surgical Indexes and Complications in Patients With Coronary Heart Disease
Authors: Tao Meiyi , Yao Xiaoling , Sun Shengli , Qin Yuelan , Li Dandan , Wu Juan , Xiong Yican , Teng Zhiyu , Zeng Yunfei , Luo Zuoheng
Published: July 2022

A total of 215 patients with coronary heart disease (CHD) were analyzed with SPSS. Samples of different genders showed significance in the obtuse marginal branch of the left circumflex branch × 1, the diagonal branch D1 × 1, and the ms PV representation. Patients with left circumflex branch occlusion are more male and tend to be younger. Age displayed a positive correlation with left intima-media thickness (IMT) and right IMT. This indicated that as age increases, the values of left IMT and right IMT increase. Samples of different CHD types showed significance in the obtuse marginal branch of the left circumflex branch × 1, the middle part of RCA × 1, and the middle part of the left anterior descending branch × 1.5. For non-ST-segment elevation angina pectoris with acute total vascular occlusion, the left circumflex artery is the most common, followed by the right coronary artery and anterior descending branch. Ultrasound of carotid IMT in patients with CHD can predict changes in left ventricular function, but no specific correlation between left and right common carotid IMT was found. Samples with or without the medical history of ASCVD showed significance in the branch number of coronary vessel lesions. The value of the branch number of coronary vessel lesions in patients with atherosclerotic cardiovascular disease (ASCVD) was higher than in those without ASCVD. The occurrence of complication is significantly relative with the distance of left circumflex branch × 1, the middle segment of left anterior descending branch × 1.5, and the distance of left anterior descending branch × 1. For patients without complications, the values in the distal left circumflex branch × 1, the middle left anterior descending branch × 1.5, and the distal left anterior descending branch × 1 were higher than those for patients with complications. The VTE scores showed a positive correlation with the proximal part of RCA × 1, the branch number of coronary vessel lesions, the posterior descending branch of left circumflex branch × 1, the distal part of left circumflex branch × 1, and the middle part of left anterior descending branch × 1.5.
Association of Systemic Inflammatory and Immune Indices With Survival in Canine Patients With Oral Melanoma, Treated With Experimental Immunotherapy Alone or Experimental Immunotherapy Plus Metronomic Chemotherapy
Authors: Garcia Jéssica Soares , Nowosh Victor , López Rossana Verónica Mendoza , Massoco Cristina de Oliveira
Published: July 2022

Analysis of the expression of inflammatory markers before starting treatment in human patients with cancer helps to predict outcomes and prognosis; however, there have been few studies on this topic in veterinary medicine. The present study aimed to evaluate inflammatory indices before treatment with autologous antitumor vaccine alone or this vaccine plus metronomic chemotherapy (MC) to predict response and prognosis. The indices included the neutrophil–lymphocyte ratio (NRL), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR), systemic immune-inflammation index (SII), C-reactive-protein–albumin ratio (CRP/ALB), lactate dehydrogenase level (LDH), frequency of blood lymphocyte subsets (CD4+, CD8+, Treg, and CD4/CD8 ratio) and frequency of blood myeloid-derived suppressor cells (MDSCs: monocytic [M]- MDSCs, and granulocytic [PMN]-MDSCs). Blood samples were collected from 25 dogs with oral melanoma treated with the autologous antitumor vaccine and from nine dogs that received MC plus vaccine before surgery. There were no statistically significant differences in the progression-free survival (PFS) or overall survival (OS) between the groups. In addition to the clinical stage, the CRP/ALB ratio and blood circulating Tregs in the univariate analysis showed an association with PFS and OS, and thus were selected for multivariable analysis. The CRP/ALB ratio was associated with PFS [hazard ratio (HR), 1.1; 95% confidence interval (CI), 1.0–1.1; p = 0.017] and OS [HR, 1; 95%CI, 1.0–1.1; p = 0.023]. Similarly, Treg was associated with PFS (HR, 1.6; 95% CI, 1.2–2.1; p = 0.001) and OS (HR, 1.6; 95% CI, 1.2–2.1; p = 0.001). Furthermore, canine patients with a CRP/ALB ratio above the cut-off point of 1.9 (established by receiver operating characteristic curve analysis) had worse PFS and OS, indicating the impact of the preoperative CRP/ALB ratio on the PFS and OS of dogs with oral melanoma. The CRP/ALB ratio and frequency of circulating Tregs are potential prognostic markers in dogs with oral melanoma.
Epidemiology of Peste des Petits Ruminants in Nigeria: A Review
Authors: Esonu Daniel , Armson Bryony , Babashani Mohammed , Alafiatayo Ruth , Ekiri Abel B. , Cook Alasdair J. C.
Published: July 2022

Peste des petits ruminants (PPR) is a major constraint to the productivity of small ruminants in Nigeria. Understanding of the current epidemiological status of PPR is crucial to its effective control. A review of the epidemiology of PPR in Nigeria was performed and research gaps were identified. Thirty-seven eligible articles were reviewed: these presented information from 30 of the 36 states of Nigeria. Most studies focused on goats and/or sheep (n= 33) but camels (n= 4), cattle (n= 1) and wild ruminants (n= 2) were also considered. Fourteen (37.8%) of the articles reported seroprevalence in small ruminants, which varied from 0.0% to 77.5% where more than 10 animals were sampled. Molecular characterization and phylogenetic analysis were performed in 6 studies, with lineages II and IV, detected in sheep and goats. In one study in small ruminants, sequences clustering into lineage I showed a similarity to the vaccine strain, Nigeria 75/1, based on phylogenetic analysis ofFgene sequences. However, if the preferred method of sequencing theNgene had been performed, this isolate would have been grouped into lineage II. According toNgene phylogenetic analysis in the other studies, sequences were identified that clustered with clade II-NigA, II-NigB (closely related to the Nigeria 75/1 vaccine strain), and others which were well separated, suggesting a high diversity of PPRV in Nigeria. Five articles reported the detection of lineage IV in 22/36 states, with IV-NigA and IV-NigB detected, highlighting its widespread distribution in Nigeria. Risk factors for PPRV seropositivity were reported in 10/37 (27.0%) articles, with a higher seroprevalence observed in female animals, although differing results were observed when considering species and age separately. There were inconsistencies in study design and data reporting between studies which precluded conduct of a meta-analysis. Nevertheless, several research gaps were identified including the need to investigate the low uptake of PPRV vaccine, and the economic benefits of PPR control measures to small ruminant farmers. Such data will inform PPR control strategies in Nigeria and subsequently contribute to the global 2030 PPR eradication strategy.
Comparative Transcriptome Analysis Reveals the Mechanism Associated With Dynamic Changes in Meat Quality of the Longissimus Thoracis Muscle in Tibetan Sheep at Different Growth Stages
Authors: Wen Yuliang , Li Shaobin , Bao Gaoliang , Wang Jiqing , Liu Xiu , Hu Jiang , Zhao Fangfang , Zhao Zhidong , Shi Bingang , Luo Yuzhu
Published: July 2022

Tibetan sheep are mainly distributed in the Qinghai–Tibet Plateau. Its meat is not only essential for the local people but also preferred by the non-inhabitant of this plateau also. To investigate the salient development features and molecular mechanism of the meat difference of LT muscle caused by different growth stages in Tibetan sheep, the carcass performance, meat quality, and comparative transcriptome analysis were performed for investigating the potential molecular mechanism of the meat quality difference of the LT muscle caused by four growth stages [4-months old (4 months), 1.5-years old (1.5 years), 3.5-years old (3.5 years), and 6-years old (6 years)] in the Tibetan sheep. The shear force increased with the increase of age (p < 0.05) while the intramuscular fat (IMF) was the highest at 1.5 y. The AMPK signaling pathway was significantly enriched in the four comparative groups. The weighted gene co-expression network analysis (WGCNA) results showed that the hub genes P4HA2, FBXL4, and PPARA were identified to regulate the meat quality. In summary, 1.5 years was found to be the most suitable slaughter age of the Tibetan sheep which ensured better meat tenderness and higher IMF content. Moreover, the genes LIPE, LEP, ADIPOQ, SCD, and FASN may regulate the transformation of the muscle fiber types through the AMPK signaling pathway, further affecting the meat quality.
Działania liderek lokalnych z gmin wiejskich w kontekście realizacji polityk publicznych
Authors: Wasil Justyna
Published: July 2022

The main goal of the paper is presents the main directions of women local leaders’ activities aimed at implementing public policies in rural municipalities. The article uses the results of empirical research (postal questionnaire and in-depth interviews). Research shows, due to the process of socialization and the issues stereotypically assigned to the female gender, (women perceive the implementation of public tasks differently), not only those related to education policy, senior policy, cultural policy, and to rural development policy.
Norma demograficzna w wyborach do rad gmin na gruncie Kodeksu wyborczego
Authors: Buczkowski Łukasz
Published: July 2022

An institution often associated with the concept of the local government electoral system is the demographic norm, which marks the boundary between the majority and proportional systems. The aim of this article was the analysis and evaluation of the course of legislative work devoted to the inclusion of the demographic norm in elections to municipal councils under the Electoral Code. The analysis allows for the assumption that the current model of appointing municipal councils is a compromise solution, partly taking into account the arguments of the supporters of the principle of majority and proportionality.
Weed Detection in Maize Fields by UAV Images Based on Crop Row Preprocessing and Improved YOLOv4
Authors: Pei Haotian , Sun Youqiang , Huang He , Zhang Wei , Sheng Jiajia , Zhang Zhiying
Published: July 2022

Effective maize and weed detection plays an important role in farmland management, which helps to improve yield and save herbicide resources. Due to their convenience and high resolution, Unmanned Aerial Vehicles (UAVs) are widely used in weed detection. However, there are some challenging problems in weed detection: (i) the cost of labeling is high, the image contains many plants, and annotation of the image is time-consuming and labor-intensive; (ii) the number of maize is much larger than the number of weed in the field, and this imbalance of samples leads to decreased recognition accuracy; and (iii) maize and weed have similar colors, textures, and shapes, which are difficult to identify when an UAV flies at a comparatively high altitude. To solve these problems, we propose a new weed detection framework in this paper. First, to balance the samples and reduce the cost of labeling, a lightweight model YOLOv4-Tiny was exploited to detect and mask the maize rows so that it was only necessary to label weeds on the masked image. Second, the improved YOLOv4 was used as a weed detection model. We introduced the Meta-ACON activation function, added the Convolutional Block Attention Module (CBAM), and replaced the Non-Maximum Suppression (NMS) with Soft Non-Maximum Suppression (Soft-NMS). Moreover, the distributions and counts of weeds were analyzed, which was useful for variable herbicide spraying. The results showed that the total number of labels for 1000 images decrease by half, from 33,572 to 17,126. The improved YOLOv4 had a mean average precision (mAP) of 86.89%.