bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple binding sites in organic cation transporters require sophisticated procedures to identify interactions of novel drugs
Authors: Koepsell Hermann
Published: August 2018

In vitro evaluation of drugs for interaction with transporters is essential during drug development. As polyspecific organic cation transporters (OCTs) are critical for pharmacokinetics of many cationic drugs, in vitro testing of human OCT1 and human OCT2 is recommended. In the currently applied tests it is determined whether uptake of one model cation in stably transfected epithelial cells is inhibited using a substrate concentration in the micromolar range. In this review experimental evidence for the existence of low- and high-affinity cation binding sites in OCTs that may interact with drugs is compiled. Most data were obtained from studies performed with rat Oct1. Whereas overlapping low-affinity cation binding sites are directly involved in transport, the high-affinity cation binding sites may induce allosteric inhibition of transport. Remarkably, high-affinity inhibition is only observed when uptake is measured using nanomolar substrate concentrations far below the respective K
m values. Affinities of inhibitors are dependent on molecular structure and concentration of the employed substrate. Because the currently applied in vitro tests for identification of interaction of novel drugs with OCTs do not consider the influence of substrate structure and are not capable of identifying high-affinity inhibition, more sophisticated testing protocols are proposed.
MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B
Authors: Sun Peng , Zhang Dan , Huang Haiping , Yu Yafeng , Yang Zhendong , Niu Yuyu , Liu Jisheng
Published: August 2018

This study aimed to investigate the role of miRNA-1225-5p (miR-1225) in laryngeal carcinoma (LC). We found that the expression of miR-1225 was suppressed in human LC samples, while CDC14B (cell division cycle 14B) expression was reinforced in comparison with surrounding normal tissues. We also demonstrated that enhanced expression of miR-1225 impaired the proliferation and survival of LC cells, and resulted in G1/S cell cycle arrest. In contrast, reduced expression of miR-1225 promoted cell survival. Moreover, miR-1225 resulted in G1/S cell cycle arrest and enhanced cell death. Further, miR-1225 targets CDC14B 3′-UTR and recovery of CDC14B expression counteracted the suppressive influence of miR-1225 on LC cells. Thus, these findings offer insight into the biological and molecular mechanisms behind the development of LC.
Converting pairing-based cryptosystems from composite to prime order setting – A comparative analysis
Authors: Chatterjee Sanjit , Prem Laxman Das M. , Kabaleeshwaran R.
Published: August 2018

Composite order pairing setting has been used to achieve cryptographic functionalities beyond what is attainable
in prime order groups. However, such pairings are known to be significantly slower than their prime order counterparts. Thus emerged a new line of research – developing frameworks to convert cryptosystems from composite to prime order pairing setting.
In this work, we analyse the intricacies of efficient prime order instantiation of cryptosystems that can be converted using existing frameworks. To compare the relative efficacy of these frameworks we mainly focus on some representative schemes: the Boneh–Goh–Nissim (BGN) homomorphic encryption scheme, ring and group signatures as well as a blind signature scheme. Our concrete analyses lead to several interesting observations. We show that even after a considerable amount of research, the projecting framework implicit in the very first work of Groth–Sahai still remains the best choice for instantiating the BGN cryptosystem.
Protocols like the ring signature and group signature which use both projecting and cancelling setting in composite order can be most efficiently instantiated in the Freeman prime-order projecting only setting. In contrast, while the Freeman projecting setting is sufficient for the security reduction of the blind signature scheme, the simultaneous projecting and cancelling setting does provide some efficiency advantage.
Information needs of young people with cerebral palsy and their families during the transition to adulthood: a scoping review
Authors: Freeman Matthew , Stewart Debra , Cunningham Charles E. , Gorter Jan Willem
Published: August 2018

The transition to adulthood is a developmental phase which occurs as young people move from adolescence into adulthood. Young people with disabilities, including cerebral palsy (CP), and their families have reported challenges during the transition to adulthood because they are required to move to adult supports and services, which are often fragmented and bring about new questions and expectations to find necessary supports. Young people and their parents have been found to lack information about where to find services in adulthood, how to access the services and what to ask during the transitional process. The aim of this scoping review was to explore the information needs of young people with CP and their families during the transition to adulthood. The goal is to map the current published evidence within the transition to adulthood literature base to explore what is known about information needs during the transition to adulthood of young people with CP and their parents. This review seeks to synthesize what is known about information content, timing, methods of provision and delivery. Databases searched were OVID Medline, CINAL, ERIC, EMBASE, PsycINFO, Web of Science, Social Science Abstracts and Sociological Abstracts. Initially 675 articles were retrieved. Four hundred and forty-two articles were selected for title review. Two hundred and five articles remained for abstract review. Seventeen articles were included for full-text review. Eleven articles were included in this review. Data were organized into five themes: (1) identified information needs during the transition to adulthood (content), (2) identified recommended providers of information during the transition to adulthood (who), (3) identified delivery methods of information during the transition to adulthood (how), (4) identified timing of information delivery of information during the transition to adulthood (when) and (5) location of information provided during the transition to adulthood (where). This review found that young people with CP, their families and adult providers all possess information needs during the transition to adulthood. Young people with CP and their families seek information about what adult services will look like and how to access supports. Adult providers require information about CP. Youth with CP prefer individualized information be delivered to them when needed rather than presented in group sessions or via paper handout. Other recommendations included the development of parent support networks to assist parents in the transition to adulthood. The opportunity to learn from real-life experiences was also viewed as an important source of information as well as method to provide information.
Treasury of the National Museum – Jewellery and Numismatic Cabinet
Authors: Kodišová Lucie , Vacinová Lenka , Sejkora Jiří , Polanský Luboš
Published: August 2018

The new Treasury of the National Museum will present rare crafts-manship of precious stones and metals in connection with the natural form of these materials. The Treasury will be followed by a Numismatic Cabinet, which will introduce the history of money from Antiquity till today. The Treasury and the Numismatic Cabinet will be interconnected in a joint hall devoted to gold and silver and they will be thematically intertwined in the hallway with the presentation of production technologies. The Treasury is created in close cooperation within the National Museum – the Natural History Museum and the Historical Museum. The base line will consist of minerals from diamonds to quartz and organic matter, which will join together with goldsmiths and artisanal arts into a unique complex. The main goal of the new Numismatic Cabinet is the establishment of a numismatic exposition that will be both scholarly exact and intriguing at the same time, educating visitors of the development of payment methods from Antiquity until today in a comprehensible and attractive way. The chronological exposition will be divided into several basic thematic sequential units.
From Backstage of the Children’s Museum Preparations
Authors: Caltová Petra , Kulhavá Zdeňka
Published: August 2018

The ambition of the Children’s Museum exposition, which is being created in the New Building of the National Museum, is to offer visitors a space for entertainment, relaxation and education. The exposition will introduce them, in an entertaining way, the natural and cultural heritage of the Czech lands in connection with unique exhibits of the new expositions in the Historical Building of the National Museum. The visitors will go through various historical events by means of the “time machine” of a scientist. The exposition will utilise a number of mechanical interactive elements, as well as modern audio-visual media. The creative team, composed mainly of museum pedagogues, will make use of their vast experience of working with children.
The Exhibition at the Hvězda Summer Palace About Emigration From Post-Revolutionary Russia and its Possible Overlapping
Authors: Hauser Jakub
Published: August 2018

The first plan of the presentation within an extremely challenging seminar entitled “Museums and their international audiences” organised by the National Museum was a short presentation of the exhibition of the Museum of Czech Literature that has been dedicated to interwar emigration from the area of the former Czarist Russia to Czechoslovakia, a major exhibition organised this year in the premises of the Hvězda Summer Palace. The purpose of the paper was not only to contribute to the promotion of the exhibition, nor would that be a sufficiently good reason for the exhibition that was trilingual and therefore completely open to both the English and the Russian-speaking visitors. The presentation was supposed to feature the other goals of the exhibition, which aimed further than simply presenting a closed historical chapter.
Crystal structure of (E)-1-(4-(((E)-3,5-dichloro-2-hydroxybenzylidene)amino)phenyl)ethan-1-one O-methyl oxime, C16H14Cl2N2O2
Authors: Fu Tao , Ma Jin-Xia , Li Qing-Lin , Wei Ping , Zhao Ji-Xing , Zhao Li
Published: August 2018

C16H14Cl2N2O2, monoclinic, P21/c (no. 14), a = 7.9157(6) Å, b = 13.4533(8) Å, c = 14.8459(10) Å, β = 103.651(2)°, V = 1536.31(18) Å3, Z = 4, R
gt(F) = 0.0410, wR
ref(F
2) = 0.1162, T = 296(2) K.
Dynamic and creep analysis of polyvinyl alcohol based films blended with starch and protein
Authors: Jain Naman , Singh Vinay K. , Chauhan Sakshi
Published: August 2018

The present study focuses on the fabrication and analyses of polyvinyl alcohol (PVA) based films blended with polymers, such as starch and protein. The aim is to improve the moisture absorption, solubility, mechanical and thermal properties of PVA by blending it with various polymers. The thermal cross-linking of the films has been studied by heating the films at 120°C for 4 h. The result shows that PVA was completely soluble in water, while post-blending solubility and moisture absorption of blended films decreased. The tensile strength of blended films was significantly higher (4%–29%) as compared to neat PVA, while thermally cross-linked films showed much higher strength (8%–174%). Blended films were characterized using Fourier transform infrared spectroscopy (FTIR) to confirm the formation of hydrogen bonds. Thermogravimetric analysis showed the increase in degradation temperature post-blending as compared to neat PVA. The viscoelastic behavior of the material as well as glass transition temperature was studied using dynamic mechanical analysis. Creep and recovery behavior were examined to study the effect of stress and temperature on creep strain. The biodegradability of the blended films was increased post-blending. This study showed that PVA based blend films can replace non-biodegradable plastics and hence are necessary for the development of environmentally friendly materials.
Physico-Chemical Stability of Sodium Thiosulfate Infusion Solutions in Polyolefin Bags at Room Temperature over a Period of 24 Hours
Authors: D’Huart Elise , Vigneron Jean , Ranchon Florence , Vantard Nicolas , Rioufol Catherine , Demoré Béatrice
Published: August 2018

Background

Many publications described sodium thiosulfate used to prevent the renal toxicity induced by cisplatin hyperthermic intraperitoneal chemotherapy. After around 60 or 90 minutes of hyperthermic chemotherapy, cisplatin was drained and then, sodium thiosulfate was infused by intravenous route. Sodium thiosulfate is used in two steps: a first step, at 9 g/m2 in 250 mL of 0.9 % sodium chloride over 10 minutes followed by a second step, at 12 g/m2 in 1000 mL of 0.9 % sodium chloride over 6 hours. The purpose of this work was to study the stability of sodium thiosulfate at 16 mg/mL in 0.9 % sodium chloride polyolefin bags 1000 mL and at 72 mg/mL in 0.9 % sodium chloride polyolefin bags 250 mL, at 25 °C, protected or unprotected from light.

Methods

Chemical stability was analysed by high performance liquid chromatography (HPLC) coupled to a photodiode array detector after preparation and after 6-hour or 24-hour storage. The method was validated according to the International Conference on Harmonisation (ICH). Physical stability was evaluated by visual and subvisual inspection (turbidimetry by UV spectrophotometry at 550 nm). Three bags for each condition were prepared. On each time of the analysis, three samples were prepared for each bag and analysed by HPLC. pH values were evaluated on each moment of the analysis.

Results

Sodium thiosulfate solutions diluted in 0.9 % sodium chloride at 16 and 72 mg/mL retained more than 95 % of the initial concentration during 24 hours. Concerning pH measurements, the maximum variation was 0.24 pH unit. No visual modification such as colour change, precipitation or gas formation was observed. The absorbance at 550 nm obtained for each sample was less than 0.010 AU.

Conclusions

Sodium thiosulfate solutions at 16 mg/mL in 1000 mL 0.9 % sodium chloride and at 72 mg/mL in 250 mL 0.9 % sodium chloride are stable physically and chemically over a period of 24 hours at 25 °C, with or without protection from light. This stability study allows the use of sodium thiosulfate in renal protection protocols during cisplatin hyperthermic intraperitoneal chemotherapy.
Development of a user-friendly drilling evaluation database system of CFRP
Authors: Wang Gong Dong , Li Nan , Peng Tian , Li Ying Chi , Xiong Xu Hai , Melly Stephen Kirwa
Published: August 2018

The drilling process of carbon fiber reinforced plastics (CFRP) is the main secondary processing in the entire production cycle. However, there is no standard theory that could be used to estimate the hole quality and to quantify the assessment. Therefore, in this article, several influential factors of drilling quality, such as drilling parameters and materials, were utilized to establish the classification tree model. A comprehensive evaluation model [three-dimensional (3D) evaluation factor] was presented to measure and quantify the quality of the hole. Then a series of experiments were designed based on existing conditions. Further, a mathematical software (Origin) was used to fit and analyze the relationships of the drilling parameters and the 3D evaluation factor. Then a user-friendly drilling database system of CFRP was established based on the historical data of drilling experiments and the fitting function. In addition, in order to contrast the optimization results of the fitting function, the drilling experiments have been conducted, and the results have verified that the drilling database system could optimally predict the drilling schemes with a minor error.
Face-to-Face Collisions of Bright and Dark Ion Acoustic Solitons in Superthermal Electrons for Different Geometrical Configurations
Authors: El-Shamy E.F. , El-Bedwehy N.A. , Shokry M. , El-Labany S.K.
Published: August 2018

The face-to-face collision of ion acoustic solitons (IASs) in superthermal plasmas composed of positive and negative ion fluids and superthermal electrons is investigated for different geometrical configurations. For the generic case, the extended Poincaré-Lighthill-Kuo (EPLK) analysis is employed to obtain the extended Korteweg-de Vries (EKdV) equations and phase shift equations. The non-linear propagation and the face-to-face collision of bright and dark IASs are studied. In addition, when the concentration of ion reaches the critical value, the EPLK method is applied to obtain the modified Korteweg-de Vries (mKdV) equations and the phase shift relations, which govern the excitation and the face-to-face collision of bright and dark IASs. Appropriately, the effects of several parameters such as the electron concentration, the superthermality of electrons and the diversity in the system’s geometry under consideration on the trajectories of IASs after the collision are discussed. Numerical calculations lead to some highlights on the properties of bright and dark IASs (e.g. in laboratory plasmas such as laser–matter/plasma interaction experiments and in astrophysical environments such as lower part of magnetosphere).
Parametric Instability of a Rotating Axially Loaded FG Cylindrical Thin Shell Under Both Axial Disturbances and Thermal Effects
Authors: Li X. , Xu Q. , Li Y.H.
Published: August 2018

Parametric instability of a rotating functionally graded (FG) cylindrical thin shell with axial compression under various boundary conditions is studied in this article. In particular, the shell is subjected to both axial periodic displacement disturbances and a thermal environment. The initial hoop tension and Coriolis effects due to rotation are also considered. The coupled dynamic equations of the shell under multiple conditions are formulated based on Love’s thin-shell theory. The instability boundaries of the shell with different boundary conditions considering thermal factors, axial disturbances, and other system parameters are obtained analytically under the case of primary and combination resonance; numerical illustrations are also given. It is found that high temperature weakens the stability of the system, while axial disturbances show stronger influence on the instability regions of the shell compared to other parameters such as thermal factors and the angular rotation velocity.
A new modification of [Ag4Br4(PPh3)4]: synthesis, structure and properties
Authors: Han Xintong , Mao Shanshan , Li Chuang , Shen Kesheng , Shi Xinkui , Huang Guozhen , Wu Huilu
Published: August 2018

A new modification of the homometallic silver(I) cluster [Ag4Br4(PPh3)4] has been prepared and characterized by elemental analysis, UV/Vis and IR spectroscopy, and X-ray crystallography. The tetramer shows a polycyclic structure with a chair conformation. The bromine atoms adopt μ
2- and μ
3-bridging modes. The shortest Ag–Ag distance in the cluster is 3.159(2) Å, which indicates significant Ag–Ag interactions. A supramolecular structure is arranged by hydrogen bonds (C–H···Br). Cyclic voltammograms of the cluster indicate a quasi-reversible Ag+/Ag couple. The fluorescence properties of the ligand and the Ag(I) cluster were studied in the solid state. The emission peaks of the Ag(I) cluster are attributed to ligand-centered luminescence.
Synthesis, characterization, and electrochemical study of a mononuclear Cu(II) complex with a 4-acyl pyrazolone ligand
Authors: Nakum Kiran , Jadeja Rajendrasinh N.
Published: August 2018

1-(2-Chlorophenyl)-3-methyl-4-propionyl-1H-pyrazol-5(4H)-one was synthesized and characterized by Fourier transform infrared (FT-IR) spectroscopy, 1H nuclear magnetic resonance, and single-crystal X-ray analysis. Its Cu(II) complex was prepared and characterized by FT-IR, thermo gravimetric analysis-differential thermal analysis, ultraviolet-visible spectroscopy, cyclic voltammetry, and single-crystal X-ray structure determination. On the basis of analytical and spectroscopic techniques, a distorted square planar geometry of the complex has been found.
Physiological and Biomechanical Responses to an Acute Bout of High Kicking in Dancers
Authors: Rice Paige E. , Gurchiek Reed D. , McBride Jeffrey M.
Published: August 2018

Rice, PE, Gurchiek, RD, and McBride, JM. Physiological and biomechanical responses to an acute bout of high kicking in dancers.J Strength Cond Res32(10): 2954–2961, 2018—High-kick precision competitive dance involves the integration of kicking inline, jumping, and turning during a 3-minute routine and causes a disturbance to both aerobic and anaerobic systems. However, no known study has quantified the effect of a hick-kick–specific protocol on blood lactate (BL), heart rate (HR), and countermovement jump (CMJ) performance. A group of adolescent high-kick dancers (n= 20; age = 15.0 ± 1.8 years; height = 161.5 ± 8.2 cm; body mass = 56.3 ± 11.0 kg; and dance team/weight lifting experience = 2.1 ± 0.9 years) participated in this investigation. Participants' BL was collected, and 3 CMJ trials were performed before (PRE) and after (POST) completing the high-kick protocol. The high-kick protocol consisted of intermittent running and kicking in place for a total of 1:45 at a tempo of 160 b·min−1, while average and peak HR (HRavg; HRpeak) were recorded. Jump height (JH), maximal trunk flexion (MTF), take-off angle (TOA), and relative peak power (PP) were determined from PRE and POST CMJ trials. During kicking, HRavgand HRpeak (n= 13) were 172.4 ± 15.7 b·min−1and 207.0 ± 23.0 b·min−1, respectively. Dancers' (n= 20) BL significantly (p≤ 0.05) increased from 1.5 ± 0.5 to 8.6 ± 1.5 mmol·L−1, and JH and PP significantly decreased from 0.42 ± 0.08 to 0.36 ± 0.04 m and 41.3 ± 5.5 to 38.5 ± 4.0 W·kg−1, respectively, from PRE to POST. No significant changes occurred in MTF and TOA measurements from PRE to POST. The demands introduced during a high-kick–specific protocol can therefore be recognized as a metabolic and mechanical stimulus for fatigue; however, esthetics seem to be unaffected. Such findings may indicate that this modality of dance necessitates supplemental strength and conditioning training similar to other sports to sustain the loads of high-kick dance.
Quadriceps Strength and Functional Performance After Anterior Cruciate Ligament Reconstruction in Professional Soccer players at Time of Return to Sport
Authors: Herrington Lee , Ghulam Hussain , Comfort Paul
Published: August 2018

Herrington, L, Ghulam, H, and Comfort, P. Quadriceps strength and functional performance after anterior cruciate ligament reconstruction in professional soccer players, at time of return to sport. J Strength Cond Res 35(3): 769–775, 2021—Poor quadriceps strength has been associated with poor outcome after anterior cruciate ligament (ACL) reconstruction (ACLR). This study aims to assess quadriceps strength, muscle inhibition, and hop test performance in professional soccer players after ACLR. Fifteen professional soccer players (age 22.3 ± 3.1 years, body mass 81.0 ± 11.5 kg, and height 1.75 ± 0.1 m) who had undergone ACLR participated. Isometric, eccentric, and concentric quadriceps strength was assessed, along with quadriceps inhibition and single and cross-over hop performance, at the time of return to full-time unrestricted play. In comparison with the uninjured leg, the ACLR leg demonstrated large significant (d ≥ 0.84, p < 0.01) deficits in isometric, eccentric, and concentric quadriceps strength, quadriceps inhibition, and hop distance. Over 80% of the players failed to exceed the limb symmetry criteria of ≥90% for strength tests, although 75% of the cohort passed the ≥90% criteria for hop tests. The outcome from ACLR in professional soccer players who received full-time intensive rehabilitation has not previously been reported in detail. There were significant deficits in quadriceps strength at the time of return to sport, whereas hop testing, a commonly used outcome measure, failed to show the same levels of deficit. These deficits in quadriceps function may have implications for the development of ongoing knee symptoms and risk of future ACL injury. If this proves to be the case, then it would seem that greater attention should be paid to re-establishing full quadriceps strength before returning to unrestricted sporting activity.
Relationship Between Body Mass, Peak Power, and Power-to-Body Mass Ratio on Sprint Velocity and Momentum in High-School Football Players
Authors: Jalilvand Farzad , Banoocy Norbert K. , Rumpf Michael C. , Lockie Robert G.
Published: August 2018

Jalilvand, F, Banoocy, NK, Rumpf, MC, and Lockie, RG. Relationship between body mass, peak power, and power-to-body mass ratio on sprint velocity and momentum in high-school football players. J Strength Cond Res 33(7): 1871–1877, 2019—The ability to rapidly shift one's body mass horizontally or vertically is common within American football irrespective of field position, and the capacity to generate power is a favorable physical quality. This requires analysis in high-school football players, especially considering the body mass disparities that exist in this population. Sixteen high-school players (7 backs and 9 linemen) completed the vertical jump (VJ) to determine jump height, peak anaerobic power measured in watts (PAPw), and power-to-body mass ratio (P:BM), and a 36.58-m sprint (0–4.57, 0–9.14, and 0–36.58-m intervals) to determine sprint velocity and momentum. Independent-samples t-tests (p < 0.05) determined differences in these variables between the backs and linemen. Pearson's correlations (r; p < 0.05) computed relationships between body mass, VJ height, PAPw, P:BM, with 36.58-m sprint velocity and momentum on the pooled data. Linemen were heavier, and slower in the 36.58-m sprint, but had greater PAPw and sprint momentum compared with backs. Body mass exhibited negative relationships to velocity across all sprint intervals (r = −0.55 to 0.70), and positive relationships with momentum across all intervals (r = 0.95–0.96). The VJ correlated with sprint velocity across all intervals (r = 0.51–0.83), but not momentum. PAPw was positively correlated with body mass and momentum across all intervals (r = 0.77–0.85), but not velocity. There were significant correlations between P:BM with velocity (r = 0.51–0.85) and momentum (r = −0.53–0.62) across all intervals. Heavier high-school players could focus on improving P:BM to positively influence jumping ability and sprint velocity.
Development and Application of a Test System for Modeling Tunnel Excavation with Transparent Rock Surrogate
Authors: Xu Guoan , Jing Hongwen , Qiu Yue
Published: August 2018

Physical modeling using transparent rock or soil surrogates and optical measurement is an effective way to obtaining the displacement and stresses within test specimens in geotechnical engineering. To apply the prospective modeling method to investigating the mechanism of excavation-induced failure of rock surrounding tunnels, a novel test system is developed for modeling tunnel excavation with transparent rock surrogate. The system includes three parts: one transparent acrylic chamber and its reinforcing units for containing scaled models, a dead-weight loading device consisting of levers and pulleys, and a three-dimension optical stressometer made of polyurethane block and fiber Bragg gratings. The test system is then employed to visualize the excavation of a round tunnel and some favorable results are gained. To some extent, the work in this article improves the physical modeling techniques and provides an effective method for the modeling research in rock tunnel engineering.
FONKSİYONEL KAKAO VE KAKAO ÜRÜNLERİ
Authors: DEMİRKOL Omca , YİĞİT Gamze Gül , CERİT İnci
Published: August 2018

Kakao ve kakaolu gıdalar, lezzetlerine ek olarak yüksek
polifenol, protein, mineral ve karbonhidrat içeriğine sahip oldukları için çok
değerli endüstri ürünleridir. Özellikle fenollerden kaynaklanan antioksidan
içerikleri, kakao ve ürünlerini fonksiyonel gıdalar kategorisine taşımıştır. Bu
nedenle kakao ürünlerinin, özellikle çikolatanın, raf ömrünün uzatılması,
zararlı bileşenlerin uzaklaştırılması veya azaltılması, besin değerlerinin ve
antioksidan aktivitesinin daha da arttırılması tüketici sağlığına kattığı
olumlu etkilerin yanında ticari ve ekonomik olarak da önem taşımaktadır. Bu
derlemede, biyolojik aktif bileşenler kullanılarak fonksiyonel özellikleri
arttırılmış kakao ürünleri hakkında yapılan araştırma ve sonuçları bir araya
getirilmiştir. Yapılan çalışmalar,  kakao
ürünlerinin biyoyararlılıklarının arttırılmasının sağlık üzerine olumlu
etkilerinden dolayı gelişmeye açık bir alan olduğunu göstermiştir.
Three years of growth hormone therapy in children born small for gestational age: results from the ANSWER Program
Authors: Rapaport Robert , Lee Peter A , Ross Judith L , Saenger Paul , Ostrow Vlady , Piccoli Giuseppe
Published: August 2018

Growth hormone (GH) is used to treat short stature and growth failure associated with growth disorders. Birth size and GH status variably modulate response to GH therapy. The aim of this study was to determine the effect of birth size on response to GH therapy, and to determine the impact of GH status in patients born small for gestational age (SGA) on response to GH therapy. Data from the prospective, non-interventional American Norditropin Studies: Web-Enabled Research (ANSWER) Program was analyzed for several growth outcomes in response to GH therapy over 3 years. GH-naïve children from the ANSWER Program were included in this analysis: SGA with peak GH ≥10 ng/mL (20 mIU/L), SGA with peak GH <10 ng/mL (20 mIU/L), isolated growth hormone deficiency (IGHD) born SGA, IGHD not born SGA and idiopathic short stature. For patients with IGHD, those who did not meet criteria for SGA at birth showed greater improvements in height SDS and BMI SDS than patients with IGHD who met criteria for SGA at birth. For patients born SGA, response to GH therapy varied with GH status. Therefore, unlike previous guidelines, we recommend that GH status be established in patients born SGA to optimize GH therapy.
Fracturas de falange tratadas con placas de osteosíntesis. Resultados a corto plazo. [Phalangeal fractures treated with osteosynthesis plates. Short -term results].
Authors: Gardenal Ricardo Martín , Seri Matías Santiago , Faccendini Sebastián José , Kalejman Gastón Bernardo , Bichara Jorge Ariel
Published: August 2018

IntroducciónSe realizó un estudio de cohorte prospectivo para evaluar los resultados funcionales de pacientes laborales con fracturas de falange tratadas mediante placas y establecer factores de mal pronóstico. Materiales y MétodosDesde mayo de 2012 hasta mayo de 2014, 55 pacientes laborales con fracturas de falange fueron operados consecutivamente, mediante reducción y osteosíntesis con placa y tornillos. Cuarenta y dos (39 hombres, edad promedio 30.76 años) fueron evaluados, con 68 falanges operadas (primera falange 15, segunda falange 53). El 28% de las fracturas fueron expuestas; el 38,24%, conminutas y el 11,76% tenía compromiso articular. El seguimiento promedio fue de 3.38 meses. ResultadosSe logró la consolidación ósea de todas las fracturas a los 1.8 meses. La movilidad para el pulgar (Gingrass) fue buena en dos casos y regular en uno. En los restantes dedos (Belsky), fue excelente (35%), buena (55%) y mala (9%). El puntaje DASH promedio fue de 18,53. Se observaron peores resultados en las fracturas de primera falange respecto de la segunda falange y en pacientes con más edad que en los más jóvenes, ambos con significancia estadística. No hubo relación entre el resultado y las demás variables estudiadas. Cuatro pacientes tuvieron complicaciones (9,5%). ConclusionesAl comparar nuestra serie con otras publicadas, hubo menos complicaciones y los resultados fueron similares, pero a diferencia de otros autores, no acostumbramos a retirar el material ni a realizar tenólisis ni artrólisis. Se logró la consolidación ósea en todos los casos y los resultados fueron satisfactorios en el 90% de los pacientes.
Tumor de células gigantes espinal en niños. Reporte de dos casos. [Spinal giant cell tumor in children. Report of two cases].
Authors: Arciniegas Benitez Omar David , Calcagni Esteban , Tello Carlos , Noel Mariano , Francheri Alejandra , Galaretto Eduardo , Remondino Rodrigo , Piantoni Lucas
Published: August 2018

El tumor de células gigantes espinal es una neoplasia de estirpe benigna y comportamiento local agresivo, de presentación rara en la población pediátrica. El dolor asociado al compromiso neurológico es la presentación típica en niños. La resección amplia del tumor y la descompresión de los elementos neurales asociada a fusión instrumentada permiten obtener una columna estable, preservar o restaurar la función neural y evitar la recidiva tumoral. Se presentan dos pacientes con tumor de células gigantes espinal en esqueleto inmaduro, sometidos a resección y estabilización mediante artrodesis instrumentada, sin recidiva en el posoperatorio alejado. La presentación clínica, la edad de los pacientes y los resultados quirúrgicos a largo plazo hacen de extremo valor el reporte de estos casos en esqueletos inmaduros.
Anastomosis entre vasos ilíacos y obturadores en la región retropúbica: estudio en cadáveres. [Anastomosis among iliac vessels and obturators in the retropubic region: Study in cadavers].
Authors: Cação Pereira Gilberto José , Nicoletti Gumieiro David , Innocenti Dinhane Daniel , Sardenberg Trajano , De Almeida Silvares Paulo Roberto , Ferreira Minicucci Marcos , Padovani Carlos Roberto
Published: August 2018

IntroducciónEn las cirugías de la región retropúbica, la sección o ruptura de la anastomosis puede causar graves hemorragias de difícil control. Nuestro objetivo fue verificar la presencia o no de anastomosis arterial o venosa entre los vasos ilíacos y obturadores en la región retropúbica.Materiales y MétodosTreinta cadáveres (14 hombres/16 mujeres; 60% de raza blanca y 40%, no blanca). Después de la disección, se verificó si había anastomosis y su distancia de la sínfisis púbica.ResultadosEl 13,3% no tenía comunicación y el 86,6% tenía algún tipo de anastomosis (p <0,01), la anastomosis venosa fue la más frecuente (p <0,05). La distancia promedio entre la anastomosis y la sínfisis púbica fue de 5,7 cm. Al comparar el sexo, la anastomosis y el lado, el 57% de los hombres presentaba anastomosis en ambos lados, y el 81% y 88% de las mujeres la tenían en el lado derecho e izquierdo, respectivamente (p <0,05). Cuando se comparó la presencia de anastomosis con el lado, el 70% estaba en el derecho y el 73%, en el izquierdo (p >0,05). El 72% de los blancos y el 67% de raza no blanca tenían anastomosis (p >0,05).ConclusionesLa presencia de anastomosis es más frecuente que la ausencia y no existe diferencia significativa en cuanto al lado. Está localizada, en promedio, a 5,7 cm de la sínfisis púbica y la venosa es significativamente más frecuente. Es significativamente más frecuente en las mujeres. No hay diferencia estadística en cuanto a la presencia de anastomosis entre la raza blanca y no blanca.
Fracturas atípicas de fémur proximal asociadas al uso prolongado de bifosfonatos.
Authors: Neder Yamile Vanina , Fazio Alejandro , Valle Pablo , Faule Facundo , Finola Mariano
Published: August 2018

IntroducciónLos bifosfonatos constituyen el tratamiento de primera elección de la enfermedad osteoporótica. Algunos efectos adversos ponen en duda su uso prolongado, como las fracturas atípicas de fémur proximal. Los objetivos de este estudio fueron determinar la relación entre consumo de bifosfonatos y fracturas atípicas de fémur, mostrar la incidencia en nuestra institución y el tiempo de consumo.Materiales y MétodosEstudio retrospectivo, observacional, análisis de caso-control no pareado. Se incluyeron pacientes >55 años, con fractura de fémur que ingresaron entre el 1 de enero de 2009 y el 31 de mayo de 2015. Las variables consideradas fueron: sexo, edad, tipo de fractura; uso, tipo y tiempo de consumo de bifosfonatos. Las fracturas se distribuyeron en típicas: pertrocantéricas, y cuello femoral, y atípicas: subtrocantéricas y diafisarias. Se consideraron como casos las fracturas atípicas y como controles, las pertrocantéricas.Resultados Se incluyó a 517 pacientes que cumplieron los criterios de inclusión. Cuarenta y dos fracturas eran atípicas y 236, típicas. Hubo predominio de sexo femenino (81,4% en los casos y 83% en los controles). La edad promedio fue de 76 y 80 años, respectivamente. La asociación con bifosfonatos fue del 44,2% en los casos y 15,3% en los controles (11,6% y 0,8% en las fracturas pertrocantéricas, respectivamente).ConclusionesEl alendronato se asoció significativamente con fracturas atípicas de fémur. No se halló relación con el tiempo de consumo; sin embargo, la incidencia fue más alta luego de 4.5-5 años de consumo.
Aloinjerto fresco congelado en cirugía de columna lumbar. ¿Aumenta la tasa de infección? [Fresh frozen allograft in lumbar spine surgery. Does it increase the rate of infection?]
Authors: Bartolomeo César , Guimbard Pérez Joint Halley , Ortiz Pablo Nicolás , Pomba Mariano , González Gustavo Alejandro , Orosco Falcone David
Published: August 2018

IntroducciónLa infección posquirúrgica en la columna lumbar es desafortunadamente común, multifactorial y una complicación potencialmente devastadora, que se asocia a un incremento de la morbilidad y la necesidad de futuras cirugías, y en última instancia, puede ser mortal. Con la intención de disminuir la morbilidad posquirúrgica, la medicación y los días de internación, comenzamos a utilizar aloinjerto fresco congelado de cabeza femoral de donantes vivos, en la artrodesis lumbar corta. El objetivo de este estudio fue comparar el índice de infección en la artrodesis lumbar corta en pacientes con aloinjerto fresco congelado y con autoinjerto.Materiales y MétodosEstudio retrospectivo de 153 pacientes divididos en dos grupos: grupo A: 84 pacientes con autoinjerto de cresta ilíaca y grupo B: 69 pacientes con aloinjerto fresco congelado, desde marzo de 2009 hasta enero 2014, sometidos cirugía instrumentada de fusión espinal lumbar posterolateral.ResultadosTres de los 153 pacientes operados se perdieron en el seguimiento (2 del grupo A y 1 del grupo B) y la muestra incluyó 150 pacientes (82 del grupo A y 68 del grupo B). Se produjeron tres infecciones por Staphylococcus aureus sensible a la meticilina, todas en el grupo A (4,5%). Ningún paciente de los dos grupos necesitó transfusión.ConclusionesEl uso de aloinjerto fresco congelado en las cirugías de columna lumbar posterolateral de causa degenerativa no se asocia a un aumento en la tasa de infección. Consideramos que el aloinjerto fresco congelado es una excelente alternativa, porque disminuye el tiempo quirúrgico y de hospitalización.
Luxación traumática aguda de la articulación tibioperonea proximal. Reporte de un caso y revisión bibliográfica. [Acute traumatic dislocation of the proximal tibiofibular joint: case report and review of the literature].
Authors: Suárez Zarrate Jessica Andrea , Rodriguez Serna Sebastian , Reyes Roy Arturo , Gallo Diaz Jairo , Rocha Libreros César
Published: August 2018

La luxación tibioperonea proximal es poco común, se relaciona con lesiones deportivas, como consecuencia de un trauma en rotación con el pie en inversión y flexión plantar, la rodilla en flexión y la pierna en rotación externa simultáneamente. Provoca dolor en la región lateral de la rodilla y la pierna, con arcos de movilidad completos de la rodilla, pero dolorosos. El diagnóstico es clínico y radiológico. Es una entidad que pasa inadvertida en el Servicios de Urgencias (60%), con consecuencias funcionales y biomecánicas si no se diagnostica oportunamente. El objetivo es describir la experiencia diagnóstica y el tratamiento ortopédico de una entidad inusual en trauma de rodilla. Se presenta a un paciente de 23 años que sufrió una caída patinando y refiere protuberancia proximal en la cara lateral de la pierna izquierda, edema, dolor y limitación para extender la rodilla.
Colgajo paraescapular en pérdidas postraumáticas de tejidos blandos de las extremidades. [Parascapular flap in post-traumatic soft-tissue loss at the limbs.]
Authors: Vanoli Fernando , Murillo Bernando Omar , Lobos Centeno Esteban , Gentile Luciano , Gutierrez Olivera Natalia , Allende Nores Christian Antonio
Published: August 2018

IntroducciónEl objetivo de este artículo es comunicar los resultados obtenidos con el uso del colgajo paraescapular para cubrir defectos severos postraumáticos de tejidos blandos en las extremidades. Materiales y Métodos Estudio retrospectivo, descriptivo, de una serie de 20 pacientes a los que se les realizó un colgajo libre paraescapular para cubrir lesiones masivas combinadas postraumáticas de tejidos blandos en las extremidades, entre 2006 y 2017. La edad de los pacientes promedió 30 años (18 hombres, 2 mujeres). La localización de las lesiones fue: 10 en antebrazo y muñeca, una en la región inguinal, siete en la pierna y dos en tobillo/pie.ResultadosEl seguimiento promedió fue de 3.6 años. Se logró la cobertura exitosa en 17 casos. El tamaño de los colgajos promedió 24,8 x 10,7 cm. Seis casos presentaron lesiones vasculonerviosa que necesitaron injerto, seis se asociaron a pérdidas óseas, once requirieron injerto de piel y cuatro, reconstrucciones tendinosas. En todos los pacientes, el área donante cerró en forma primaria y sin secuelas funcionales. Dicho colgajo se combinó con el escapular en tres casos y con colgajo de dorsal ancho en tres casos. Dos colgajos fallaron y debió amputarse la extremidad lesionada; un paciente falleció por embolia masiva al séptimo día de la cirugía.ConclusionesEl colgajo paraescapular permitió salvar y reconstruir satisfactoriamente defectos masivos extensos en 17 de 20 extremidades, sin morbilidad para la zona donante del colgajo, pero su uso no está exento de complicaciones, y un abordaje multidisciplinario es necesario para disminuir esta morbilidad.
Informe sobre la radio-exposición en el personal quirúrgico de Ortopedia y Traumatología.Principios, marco legal y análisis situacional en la Argentina.
Authors: Vivas Mauro Rafael , Herrera Horacio Sixto , Guyot Juan Pablo , Santini Araujo Maria Gala , Dello Russo Bibiana , Castellini Jorge
Published: August 2018

La cirugía ortopédica ha avanzado mucho en estos años y, con ello, el uso de la intensificación de imágenes en el quirófano. El objetivo de este informe es revisar los principios biológicos de la radiación, el marco legal actual y hacer una breve reseña sobre la situación actual en la Argentina.
Presentación del caso.
Authors: Ghisi Juan Pablo , Abraham Zulma , Trache Adrian
Published: August 2018

Hombre de 45 años de edad, que consulta por dolor plantar del pie izquierdo y dificultad para deambular. Durante la inspección, en la piel, se reconoce una herida corto-punzante de unos 5 cm de extensión, en la cara medial del tercio distal de la pierna izquierda, por la que recibió cobertura antibiótica. El examen físico revela hiperalgesia a la palpación del pie. Refiere como antecedente cardinal un accidente de moto 10 días antes del comienzo de los síntomas plantares, con un traumatismo en la zona del tercio distal de la pierna izquierda, por el que fue sometido a un estudio radiológico rutinario. La algia plantar persistente motiva la realización de una resonancia magnética (RM). Ante los hallazgos de este estudio, se decide complementar con estudio Doppler, que confirma el diagnóstico.
Resolución del caso.
Authors: Ghisi Juan Pablo , Abraham Zulma , Trache Adrian
Published: August 2018

Resolución del caso.
Residencias y algo más...
Authors: Tello Carlos
Published: August 2018

Residencias y algo más...
Cardio-oncology: A Focus on Cardiotoxicity
Authors: Koutsoukis Athanasios ,   Department of Clinical Therapeutics, National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece, Ntalianis Argyrios ,   Department of Clinical Therapeutics, National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece, Repasos Evangelos ,   Department of Clinical Therapeutics, National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece, Kastritis Efsthathios ,   Department of Clinical Therapeutics, National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece, Dimopoulos Meletios-Athanasios ,   Department of Clinical Therapeutics, National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece, Paraskevaidis Ioannis ,   Department of Clinical Therapeutics, National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece
Published: August 2018

Cardio-oncology is a recently developed field in cardiology aimed at significantly reducing cardiovascular morbidity and mortality and improving quality of life in cancer survivors. Cancer survival rates have been constantly increasing, mainly because of the advent of new, more potent and targeted therapies. However, many of the new therapies – along with some of the older chemotherapeutic regimens such as anthracyclines – are potentially cardiotoxic, which is reflected increasingly frequently in the published literature. Cardiotoxicity adversely affects prognosis in cancer patients, thus its prevention and treatment are crucial to improve quality and standards of care. This review aims to explore the existing literature relating to chemotherapy- and radiotherapy-induced cardiotoxicity. An overview of the imaging modalities for the identification of cardiotoxicity and therapies for its prevention and management is also provided.
Візуалізація суспільного життя окупованої території Луганської області у друкованих засобах масової інформації
Authors: Kotelenets Kateryna M.
Published: August 2018

Розглядається суспільне життя окупованої території Луганської області у друкованих засобах масової інформації. Зазначена методологія дослідження, розписані методи та методологія дослідження друкованих засобів масової інформації, складена вибірка. Наводяться деякі результати контент-аналізу газет, які друкувались протягом року у трьох населених пунктах так званої Луганської народної республіки, а саме: Луганську, Стаханові (Кадіївці) та Антрациті. Проаналізовані світлини обраних газет, які відображають суспільні процеси на окупованій території Луганської області. Саме світлини надають змогу зробити висновок, що газети мають інформаційний напрям контенту, що інформація, яка в них надається, найчастіше має побутовий або економічний характер, а також, що концентрується увага на ситуативних заходах. Доведено, що світлини мають розбіжності між розміром та контекстом, тобто незначна кількість світлин компенсується їх великим розміром, особливо політичних лідерів Російської Федерації та самої так званої Луганської народної республіки. Робиться висновок, що фотографії на шпальтах газет так званої ЛНР найчастіше відображають інфраструктурні, побутові проблеми та проблеми благоустрою, а також концентрують увагу на культурному та розважальному житті так званої Луганської народної республіки.