bluuebunny/crossref_metadata_2025 huggingface dataset:
Dari Modernisme ke Salafisme: Transformasi Pemikiran tentang Islam dan Demokrasi di Indonesia
Authors: Wilandra Syaidina Sapta
Published: December 2024

Artikel ini bertujuan untuk menganalisa bagaimana kalangan umat Islam di Indonesia merespon penerapan sistem demokrasi dari masa awal kemerdekaan hingga masa reformasi. Penelitian menggunakan metode sejarah dengan tahapan heuristik, verifikasi, interpretasi, dan historiografi. Dari hasil penelitian ini ditemukan bahwa di masa awal kemerdekaan secara umum para tokoh Islam di Indonesia menyepakati penerapan sistem demokrasi dengan catatan bahwa dasar negara haruslah berdasarkan Islam. Namun di masa Orde Baru muncul generasi baru yang berpaham Salafi yang secara lugas justru menolak sistem demokrasi dan menganggapnya bertentangan dengan Islam. Padahal generasi baru yang berpaham Salafi ini pun lahir dari organisasi Islam modernis, yang di masa awal kemerdekaan itu menerima dan memperjuangkan demokrasi di Indonesia. Hal ini menunjukkan adanya perubahan dan keberagamaan dari kalangan umat Islam, khususnya beberapa kelompok Islam modernis, dalam merespon dan memaknai ajaran Islam dalam kaitannya dengan pemikiran politik.
Bibliometric Analysis of Human Resource Management Research in Islamic-Based Hospitals (2014-2023)
Authors: Hariyadi Ilham , Aini Qurratul
Published: December 2024

General Background: Human Resource Management (HRM) is vital for achieving organizational goals, particularly in hospitals where it influences healthcare quality. Specific Background: In Islamic-based hospitals, HRM must align with Islamic values, adding complexity to management practices. Knowledge Gap: There is a lack of bibliometric analysis on HRM research in these hospitals. Aims: This study aims to assess HRM research in Islamic hospitals from 2014 to 2023, identify trends, and highlight research gaps. Results: Research in this area increased notably between 2020 and 2023, with the United States leading. Key themes included hospital management, employee satisfaction, and organizational efficiency. Novelty: This is the first bibliometric analysis of HRM in Islamic-based hospitals. Implications: The findings suggest the need for more research on HRM strategies rooted in Islamic values to enhance hospital performance and healthcare quality.
Highlights:

Significant increase in HRM research publications in Islamic hospitals from 2014 to 2023.
The United States contributed the most research on HRM in Islamic hospitals.
Key themes included employee satisfaction, hospital management, and organizational efficiency.

Keywords: Human Resource Management, Islamic Hospitals, Bibliometric Analysis, Healthcare Quality, Organizational Performance
GEOLOGICAL CONDITIONS OF FORMATION AND DISTRIBUTION OF GAS-GEOCHEMICAL FIELDS IN BOTTOM SEDIMENTS OF THE LAPTEV-SIBERIAN SEA ZONE OF THE EAST ARCTIC SHELF
Authors: Gresov A.I. , Yatsuk A.V.
Published: December 2024

Gas composition of bottom sediments of the Laptev-Siberian Sea geostructural zone (LSZ) was determined to include: helium and hydrogen in concentrations of 0.0028–0.2092 and 0.0012–0.8727 cm3/kg, hydrogen sulfide – 0.0006–0.0072, carbon monoxide – 0.0016–0.0577, carbon dioxide – 0.1482–21.1602, methane – 0.0017–8.3047 and its homologues (in total) – 0.00001–0.0355 cm3/kg. It was found that the values of average concentrations of gases in bottom sediments increase with the depth of their occurrence and exceed the anomaly criteria identified for the East Arctic shelf by 2.6–27.7 times, including: CO2, CO and H2S – by 2.6, 3.0 and 3.4 times, ΣC2–C5 and He – by 9.3 and 10.8 times, CH4 – by 27.7 times; this actually indicates a high degree of gas saturation of bottom sediments of the region. The formation of CO2, CO, H2S, H2, CH4 and ΣC2–C5 anomalies in sediments of the upper and the base of the middle sampling horizon is determined by relatively high contents of sapropelic and humic organic matter and gas influx from the lower horizon. Distribution of anomalies with maximum concentrations of natural gases and He in sediments of the lower horizon, with minimum contents of Corg, is associated with zones of faults, large dislocations, tectono-magmatic and seismic activity, which are the main routes of diffusion-migration of gas transfer to bottom sediments. Formation of concentrations of gases and their anomalies in sediments of the LSZ follows the rules of additivity, i.e. successive accumulation of migratory natural gases of different genesis with prevalence of gas phase and isotopic indicators of more gas-saturated parental source, epigenetic and syngenetic to sediments. It was found that maximum values of average gas saturation with CH4, ΣС2–С5, He and H2 in LSZ are typical for bottom sediments of the flanks of troughs, CO and CO2 – for the arch parts of uplifts. In sediments of monoclinal folds (structural terraces), minimal values of average gas saturation are observed, with the exception of the South Anyui Fault Zone. In general, gas saturation of LSZ sediments is determined by the complex impact of geological factors, with the major ones being: gas content of rock complexes and gas saturation of underlying sediments, fault and fold tectonics, a high degree of tectono-magmatic and seismic activity, a geostructural position, coal content, oil and gas content, as well as the depth of occurrence, organic saturation and material composition of OM in bottom sediments. The influence of the latter predetermined the formation and distribution of five geochemical fields of CH4, three of CO, ΣС2–С5, He and one of CO2, and one of H2 in LSZ.
The Relationship Between Resilience and Mental Health, Mobile Phone Addiction and Its Differences Across Levels of Parent-Child Conflict Among Left-Behind Adolescents: A Cross-Sectional Network Analysis
Authors: yuan xiaoya , Mao Yaxin , Xu Xiaomin , Peng Ruolan , Tang Min , Dai Gang , Tang Xinyi , Fu Haojie , Zhong xiao , zhang Guanzhi , Wang Bin
Published: December 2024

Background mobile phone addiction and mental health problems have become increasingly prominent among left-behind adolescents in China. In recent years, some studies have focused on the important role of parent-child relationship and psychological resilience. Therefore, this study aims to explore the multidimensional relationships among resilience, mental health, and mobile phone addiction among left-behind adolescents, and to assess the impact of parent-child conflict level on these relationships.Methods The Brief Symptom Inventory (BSI-18), the Chinese version of the Mobile Phone Addiction Index (MPAI), the Resilience Scale for Children and Adolescents (RSCA), and the Parent-Child Conflict Scale were used to investigate 2,100 left-behind adolescents in Sichuan Province, and R was run to make network analysis and network comparison.Results (1) A structurally stable network relationship exists between left-behind adolescents' resilience, mental health, and mobile phone addiction; (2) BSI3 (Anxiety) is the most important node of the network model, followed by MPAI1 (the inability to control cravings subscale); (3) MPAI1 (the inability to control cravings subscale) and RSCA4 (family support) are key to connect resilience, mental health, and smartphone addiction in the study sample; (4) There was a significant difference in the network structure between the high- and low-level groups of parent-child conflict, no significant difference in the global strength of the network, and a significant difference in the centrality of strength and the centrality of bridge strength.Conclusions Chinese left-behind adolescents' resilience and mental health, mobile phone addiction are both independent and interact with each other to some extent. Specifically, high centrality dimensions such as anxiety, the inability to control cravings, and family support can be prioritised for intervention in related treatments, or reducing parent-child conflict and enhancing resilience to mitigate mobile phone addiction among left-behind adolescents, thus improving their mental health.
Radiomics feature extraction from ultrasound B-mode images and radiofrequency signals of the carotid arterial wall: a feasibility study
Authors: Jadoon Maryam , Poli Federica , Boutouyrie Pierre , Khettab Hakim , Bianchini Elisabetta , Faita Francesco , Jouven Xavier , Empana Jean Philippe , Bruno Rosa Maria
Published: December 2024

Background: Carotid ultrasound is largely used to assess arterial aging. Radiomics applied on ultrasound may allow characterizing wall ultrastructure and arterial aging, however to date its application to the intima-media complex is unexplored. The aim of this study is to investigate the feasibility and reproducibility of radiomic features extraction and selection in describing the common carotid wall ultrastructure.
Methods: Radiofrequency signals from 200 individuals in the Paris Prospective Study III cohort were used to extract RF and B-mode features. Feature stability across 3 frames from the same clip and 5 ROI sizes for each frame was evaluated by Intraclass Correlation analysis (threshold >0.50). Lasso L1 regression for chronological age prediction on ICC >0.50 features were used to analyze reproducibility and variation across frames and ROI sizes; 80/20 train-test split was used, with performance evaluated by MSE and R².
Results: Radiomic feature extraction was feasible in 190 out of 200 individuals. 48 features showed an ICC > 0.50. Feature selection for chronological age prediction showed consistent R² (0.09-0.14 train, 0.05-0.13 test) and MSE (32.3-34.3 train, 30.7-42.3 test) across frames. Fixed ROI sizes of 1.0mm and 1.2mm had comparable performance to a ROI size manually tailored to wall thickness: R² (0.07-0.15 train, 0.07-0.17 test), MSE (33.15-36.22 train, 33.07-34.83 test), consistently selecting substantially similar 3-6 features.
Conclusion: Radiomic ultrasound features describe carotid wall ultrastructure in a reproducible manner. While feature extraction and selection process are largely reproducible across frames, ROI size proved critical and thus must be carefully chosen.
Role of Stimulating Combined Visceral Meridians by Laser Acupuncture on Asthma Exacerbation and Quality of Life of Asthmatic Patients
Authors: Sharkawy Asmaa Al , Hamdy Gehan , Gharib Ahmed , Elsheikh Mai
Published: December 2024

Background: Asthma patients with atopic tendencies often experience airway inflammation and structural changes. Common triggers for asthma exacerbations include exercise, specific foods, and respiratory viral infections. Acupuncture has been investigated as a possible treatment for asthma management, but the efficacy of specific acupuncture points remains uncertain.
Objective: This study aimed to evaluate the impact of stimulating specific acupuncture points along combined visceral meridians on asthma exacerbations triggered by various factors. It also assessed improvements in quality of life, focusing on symptoms, daily activities, environmental influences, and health-related quality of life (HRQoL) using the Mini Asthma Questionnaire.
Method: The study included 50 patients with chronic persistent asthma who were randomly assigned and categorized based on the Global Initiative for Asthma (GINA) guidelines for asthma control. Over five weeks, participants underwent 12 laser acupuncture (LA) sessions targeting acupuncture points on the Lung, Heart, Conception Vessel, Spleen, and Stomach meridians. A low-level laser (780 nm wavelength, 800 mW output) was used to deliver 9.6 J/cm² per acupoint in continuous mode. Outcomes were assessed at baseline and five weeks post-treatment using the Mini Asthma Questionnaire, Asthma Control Test (ACT), and Forced Expiratory Volume in 1 second (FEV1).
Results: Following five weeks of laser acupuncture sessions, there was a significant improvement in exercise tolerance (p < 0.001) and a marked reduction in asthma exacerbations triggered by viral infections and food allergies (p < 0.001). The overall Mini Asthma Questionnaire scores were significantly increased from 37.08 ± 10.14 at baseline to 72.60 ± 9.97 post-treatment (p < 0.001). Spirometry findings demonstrated a significant improvement in FEV1 (p > 0.005).
Conclusion: Laser acupuncture targeting combined visceral meridians shows promise in enhancing exercise tolerance and reducing asthma exacerbations caused by viral infections and food allergies. This approach significantly improves the quality of life for school-aged children with asthma.
Familiarity versus Favorability: Exploring Formal Autism Terminology in Chinese Language Discourse
Authors: Lao Uchong , Liang Fengjing , Dai Jiamin , Wei Cao , Chen Qian , Zou Xiaobing , Zhu Huilin
Published: December 2024

The emergence of the neurodiversity movement has stimulatedrobust dialogues about autism-related terminology in Western societies, yet this subject remains largely unexplored in China. Considering that distinct sociocultural contexts can engender diverse perceptions of autism, it is crucial to foster discussions on appropriate language within the Chinese framework. This will not only enhance understanding and acceptance but also contribute to a more inclusive society for individuals on the autism spectrum. In the Chinese language context, especially Simplified Chinese, two translations for “autism” coexist: “孤独症” (GuDuZheng, GDZ, “GuDu” means “isolation/loneliness” and “Zheng” means disease/symptoms) and “自闭症” (ZiBiZheng, ZBZ, “ZiBi” means “self closing-off”), reflecting a crucial aspect of the localization of autism-related language. Using mixed-methods, four Simplified Chinese formal terminologies (GDZ, GDZspectrum disorder, ZBZ, ZBZspectrum disorder) were searched and analyzed in academic databases, search engines, and social networks, while the rankings of the terminologies and reasons for autistic people(n = 91), autistic people with an autistic child (n = 14), non-autistic people with an autistic child (n = 291), specialists (n= 141), the public(n = 441), and undefined identities (n = 38) were also being surveyed. Results revealed that participants expressed a strong preference for GDZspectrum disorder, with an aversion to ZBZ, which was more prevalent in publications and online discourse. Thematic analysis revealed that preferences and offensiveness were primarily driven by semantic concepts, associations and familiarity with the terms. This study highlights disparities in familiarity and favorability of formal autism-related terminologies in Chinese language, underscores the need for increased awareness and education on autism language choices in East Asian cultures, and enhancing global understanding of autism language dynamics and neurodiversity.
Factors Associated with Psycho-behavioral Problems among 100 Phenylketonuria Children Aged 6-18 Years
Authors: Xue Mei , Niu Wenquan , Shen Ming , Wang Shunan , Pang Bo , Zhang Xiaoqian , Chen Kening , Zhang Zhixin
Published: December 2024

Background
Phenylketonuria (PKU) is a rare condition, and children diagnosed with PKU often face psycho-behavioral challenges, which can significantly impact their daily lives and social integration. Our objective was to evaluate the prevalence of psycho-behavioral difficulties and explore potential factors associated with their occurrence in PKU children aged 6–18 years.
Methods
From May 2022 to May 2024, we recruited 100 children with PKU using a questionnaire survey. Data were analyzed using STATA software and the R programming language.
Results
25% of children aged 6–18 years with PKU exhibited psycho-behavioral problems. Following multivariable adjustment, significant factors associated with these psycho-behavioral problems in the children were body mass index (BMI) (odds ratio, 95% CI, P: 95% CI: 1.135, 1.010–1.276, 0.033), age (3.169, 1.024–9.804, 0.045), pregnancy order (0.143, 0.033–0.607, 0.008), delivery order (0.041, 0.004–0.373, 0.005), mode of disease diagnosis (5.730, 1.935–16.963, 0.002), and dietary therapy pressure (3.321, 1.083–10.181, 0.036). A nomogram was constructed based on above significant factors, with descent prediction capability and accuracy.
Conclusions
Six factors were identified to be closely associated with psycho-behavioral problems in PKU children. Our findings provide insights into the risk profiles behind psycho-behavioral issues in PKU, potentially enabling the development of preventive strategies.
Characterization of Wastewater and Detection of Ceftriaxone at Tirunesh Beijing General Hospital, Addis Ababa, Ethiopia
Authors: Tesfa Genetu Tesfa , Worku Abebe , ayalneh shiferaw , Weldemiachael Tsedekech
Published: December 2024

This study was assessed the physicochemical characteristics of wastewater discharged from Tirunesh Beijing General Hospital, Addis Ababa, Ethiopia. The results were evaluated concerning compliance with the standards set by the Ethiopian Environmental Protection Agency. The results showed that significant deviations from the set standards by the EEPA. Especially, the pH value was within the accepted range at 7.05 ± 0.19, while the EC showed a very high value of 1.576 ± 0.0043 µS/cm exceeded a standard value of 1 µS/cm. Total nitrogen (TN) (0.1295 ± 0.0041 mg/L), and total phosphorus (TP) (0.46744 mg/L) which was below the standard limit. However, the BOD and COD values exceeded their accepted limits at 12.7 ± 0.56 mg/L and 138.677 ± 3.955 mg/L, respectively. Analysis for heavy metals also showed that lead (0.1134 mg/L), chromium (0.07833 mg/L), and cadmium (0.03191 mg/L) were above Ethiopian EPA limits. Ceftriaxone concentrations on another hand were (0.083 µg/mL) which exceeded the discharge limit of 0.03 µg/L. These results emphasize the need for a wastewater treatment system at Tirunesh Beijing General Hospital to minimize environmental pollution and protect public health. The relatively high levels of detected contaminants pose great risks like the development of antibiotic resistance bacteria and resistance genes that affect both aquatic life and human health.
Experiences of Stigmatization and Its Impacts Among Individuals Living with Hereditary Diseases and Family Members in Portugal: An Exploratory Mixed-Method Study
Authors: Valentim Joana , Paneque Milena , Mendes Álvaro
Published: December 2024

Introduction: Stigma is defined as the perception of an undesirable attribute that leads to discrimination against individuals and groups. Stigmatisation is often triggered due to visible physical or cognitive differences. Although the literature consistently highlights the (fear of) stigmatisation as a significant concern among individuals living with hereditary conditions, no studies in Portugal have specifically provided evidence on this issue. This study aims to address this gap by examining the experiences and impact of stigma on individuals and families affected by hereditary diseases in Portugal.
Methodology: After receiving ethics approval, a total of 216 participants, including affected individuals, asymptomatic carriers and family members from families with a range of hereditary conditions, were recruited through patient support associations. Participants completed an online questionnaire via Limesurvey. Data were analysed through Exploratory Factor Analysis (EFA), median comparison tests, and thematic analysis.
Results: Of the participants, 78.7% were women, 55.6% had a university degree, and 20.4% were aged between 42 and 47 years. Findings indicate that stigma impacts individuals across various domains, including social interactions, institutional settings, the workplace, and healthcare. EFA identified a bi-factorial model of stigma, comprising Stigma Experiences and Perceived Support subscales, and the overall scale demonstrated high internal consistency (α = .879). Women and younger participants reported higher levels of stigma. Religiosity and humor emerged as key coping strategies.
Discussion: This study is the first in Portugal to assess stigma among individuals living with hereditary conditions. Our findings contributed to validating a measurement instrument, identified sociodemographic variations, and examined the psychosocial dimensions of stigma among affected patients. These findings highlight the need for comprehensive strategies to address and mitigate stigma, improve support systems, and enhance the well-being and healthcare experiences of individuals and families impacted by hereditary diseases.
Preferences for long-term care among elderly stroke patients with disabilities : a protocol for a discrete choice experiment
Authors: Zha Huixian , Mao Wenjun , Jiang Ling , Yan Hongyun , guo Hua , Li Xianwen , Tian Xingyue
Published: December 2024

Background
Stroke is one of the leading causes of disability among older adults worldwide, often resulting in significant physical, cognitive, and emotional impairments that require long-term care (LTC). With aging populations and increasing stroke prevalence, the demand for appropriate and sustainable LTC is expected to grow substantially in the coming years. However, designing such LTC to meet the complex and evolving needs of elderly disabled stroke patients remains a challenge. Understanding patients’ preferences is crucial for the development of patient-centered care plans and optimizing the LTC strategy for stoke patients with disabilities. This study uses a discrete choice experiment (DCE) to measure and quantify patients’ preferences for LTC, and aims at (1) identifying and exploring which elements of LTC are essential for elderly disabled stroke patients; (2) measuring patients’ preferences for LTC and summarising relevant characteristics that may influence preference choices and (3) determining whether these preferences vary by participants characteristics and classifying the population types based on the baseline data and activities of daily living.
Methods
The research was conducted in accordance with the design programme of the DCE study. Seven attributes were developed through a systematic literature review, in-depth interviews and experts consultation. A partial factorial survey design was generated through an orthogonal experimental design to optimize the choice scenario sets. We plan to conduct a DCE questionnaire survey in Suzhou, Jiangsu province, China and recruit at least 200 participants. The final data will be analysed through a mixed logit model and a latent class model to explore the preference of elderly disabled stroke patients for LTC.
Discussion
The study will provide insights into the LTC preferences of elderly stroke patients with disabilities. By quantifying the importance of various LTC attributes, the findings will help policymakers and healthcare providers design tailored, sustainable LTC services. The use of mixed logit and latent class models will uncover both general preferences and distinct patterns of preference heterogeneity, enabling the development of personalized LTC models that align with patients’ specific needs.
The Effect of Mindfulness-Based Cognitive Therapy on Auditory Hallucinations in Patients with Schizophrenia: A Randomized Controlled Trial
Authors: Tang Qiubi , Zhou Wenqing , Zheng Tao , Ye Dongmei , Cao Weiye , Huang Fengxia , He Xijie , Peng Mingchuang , Huang Xingbing , Yang Shuixian
Published: December 2024

Background
Schizophrenia is a severe mental disorder characterized by symptoms such as auditory hallucinations, which can seriously impact patients' quality of life and social functioning. Mindfulness-Based Cognitive Therapy (MBCT) has emerged as a promising non-pharmacological intervention to manage these symptoms. This study aims to evaluate the effectiveness of MBCT on auditory hallucinations, self-management abilities, and mindfulness levels in patients with schizophrenia.
Methods
A randomized controlled trial was conducted with 75 stable inpatients diagnosed with schizophrenia and experiencing auditory hallucinations. Participants were randomly assigned to either a control group (treatment as usual, TAU, n = 37) or an experimental group receiving MBCT in addition to TAU (n = 38). The intervention consisted of eight weekly sessions of MBCT. Outcome measures, including the Psychotic Symptom Rating Scale - Auditory Hallucinations (PSYRATS-AH), the Schizophrenia Self-Management Scale (SSMIS), and the Five Facet Mindfulness Questionnaire (FFMQ), were assessed at baseline and after the 8-week intervention.
Results
The experimental group demonstrated a significant reduction in the severity of auditory hallucinations (P < 0.001) compared to the control group. Furthermore, the experimental group showed substantial improvements in self-management abilities (P < 0.001) and mindfulness levels (P = 0.025) following the intervention. The study indicates that MBCT effectively enhances patients' ability to manage auditory hallucinations, improves overall self-management, and increases mindfulness levels.
Conclusion
For the management of auditory hallucinations in people with schizophrenia, MBCT is a viable supplementary treatment. It not only reduces the severity of these symptoms but also enhances self-management capabilities and mindfulness levels, contributing to better overall outcomes. Incorporating MBCT into standard care practices could offer a valuable, non-pharmacological option for clinicians in psychiatric settings.
Trial registration
Chinese Clinical Trial Registry ChiCTR2400088029. Date of registration: 09/08/2024.
Exploring the Potential of Actinobacteria as Plant Growth Promoters in Cowpea
Authors: Lalithesh Niveditha Nelamangala , Devaki Girija , Gopal Kulkarni Surendra , Vijayaraghavan Reshmy , Unnikrishnan Bobby
Published: December 2024

The study includes isolation, characterization and evaluation of actinobacteria for plant growth promotion in cowpea. Actinobacteria were isolated from four soil and three compost samples on starch casein agar and total 50 morphotypes were maintained including 21 isolates from the Department of Agricultural Microbiology repository. All 50 isolates were subjected to screening for direct plant growth promoting (PGP) activities including nitrogen fixation, phosphate, potassium and zinc solubilization and production of indole-3-acetic acid. Indirect PGP activities including production of hydrogen cyanide, ammonia and siderophores were also tested under in vitro conditions. Compatibility among isolates was tested via cross-streak method and five actinobacterial consortia were developed for further in planta studies. A total of 29 actinobacterial isolates were obtained from rhizosphere soil and compost samples, with cowpea rhizosphere soil exhibiting the highest population density. Based on in vitro screening and PGP ranking of all the 50 isolates, 15 isolates with PGP ability were selected for further cultural, biochemical and morphological characterization. The evaluation of five compatible consortia led to significant improvement in growth and yield parameters of cowpea compared to treatment of PGPR Mix 1 and control (P ≤ 0.05). T2 consortium (Streptomyces fumigatiscleroticus and Streptomyces sp. strain PAS3) recorded significantly higher number of pods (23.8), number of seeds per pod (12.1), test weight (22.8 g), fresh (120.2 g) and dry weight (15.6 g) of pods, indicating their potential benefits for plant growth and yield. This research suggested actinobacterial consortia as viable biofertilizers, enhancing cowpea growth and contributing to environmentally sustainable agriculture.
Fully automatic categorical analysis of striatal subregions in dopamine transporter SPECT using a convolutional neural network
Authors: Buddenkotte Thomas , Lange Catharina , Klutmann Susanne , Apostolova Ivayla , Buchert Ralph
Published: December 2024

Objective
To provide fully automatic scanner-independent 5-level categorization of the [123I]FP-CIT uptake in striatal subregions in dopamine transporter SPECT.
Methods
A total of 3,500 [123I]FP-CIT SPECT scans from two in house (n = 1,740, n = 640) and two external (n = 645, n = 475) datasets were used for this study. A single convolutional neural network (CNN) was trained for the categorization of the [123I]FP-CIT uptake in unilateral caudate and putamen in both hemispheres according to 5 levels: normal, borderline, moderate reduction, strong reduction, almost missing. Reference standard labels for the network training were created automatically by fitting a Gaussian mixture model to histograms of the specific [123I]FP-CIT binding ratio, separately for caudate and putamen and separately for each dataset. The CNN was trained on a mixed-scanner subsample (n = 1,957) and tested on one independent identically distributed (IID, n = 1068) and one out-of-distribution (OOD, n = 475) test dataset.
Results
The accuracy of the CNN for the 5-level prediction of the [123I]FP-CIT uptake in caudate/putamen was 80.0/77.8% in the IID test dataset and 78.1/77.3% in the OOD test dataset. All 4 regional 5-level predictions were correct in 53.1/52.6% of the cases in the IID/OOD test dataset. A global binary score automatically derived from the regional 5-scores achieved 97.4/96.2% accuracy for automatic classification of the scans as normal or reduced relative to visual expert read as reference standard.
Conclusions
Automatic scanner-independent 5-level categorization of the [123I]FP-CIT uptake in striatal subregions by a single CNN model is feasible.
The Impact of Ultrasound-guided Greater Auricular Nerve Block on Emergence Agitation in Children Undergoing Cochlear Implantation
Authors: Dong Junli , Zou Tianxiao , Yu Shenghua , Lou Man , Shi Jiahuan , Song Zhaomeng
Published: December 2024

Objective
This prospective, randomized, controlled trial aims to determine whether ultrasound-guided greater auricular nerve block (GANB) can reduce emergence agitation in children undergoing cochlear implantation.
Methods
In this prospective, randomized, controlled trial, we enrolled 100 children (aged 8 months to 6 years) scheduled for cochlear implantation. They were randomly assigned to one of two groups: the GANB group and the control group. The GANB group received an ultrasound-guided GANB with 2 mL of 0.25% ropivacaine, whereas the control group received no injection. Postoperatively, the incidence of emergence agitation was assessed using the Paediatric Anaesthesia Emergence Delirium (PAED) scale, and pain was evaluated using the Face, Legs, Activity, Cry, Consolability (FLACC) scale. Children with a PAED score ≥ 13 or a FLACC score ≥ 4 were treated with 0.1 µg/kg of sufentanil.
Results
A total of 90 children (n = 45 per group) completed the study. The end-tidal concentration of sevoflurane was lower in the GANB group than in the control group. The incidence of emergence agitation was 17.7% in the GANB group, compared to 42.2% in the control group (P = 0.011). The PAED scale scores were lower in the GANB group (6 [4–8.5]) than in the control group (9 [6–12]). The duration of emergence agitation was shorter in the GANB group, and the FLACC scores in the post-anaesthesia care unit were lower in the GANB group (1 [1–2]) compared to the control group (3 [1–3]).
Conclusions
Ultrasound-guided GANB performed before surgery significantly reduced the incidence and duration of emergence agitation in children undergoing cochlear implantation. It also provided satisfactory postoperative analgesia without delaying extubation.
Impact of inoculation of inactivated COVID-19 vaccine on the outcomes of frozen-thawed embryo transfer
Authors: Qiu Yu , Chen Fu-rui , Leng Mei , Deng Xi , Liang Mei-yu , Wei Jia-jing , Chen Shi-qi , Hei Jing , Ma Rong-ning , Li-Ling Jesse , Gong Yan
Published: December 2024

To assess the impact of inoculation of inactivated corona virus disease 2019 (COVID-19) vaccine on the outcome of frozen-thawed embryo transfer (FET). From January 2022 to November 2023, patients aged 20 ~ 45 years old undergoing FET at the Reproductive Medicine Center of a tertiary teaching hospital were prospectively enrolled. The patients were divided into vaccinated group (n = 458) and unvaccinated group (n = 530) based on the inoculation of inactivated COVID-19 vaccine before FET. Vaccinated group was further divided into three subgroups based on the dose (single dose, n = 55; double dose, n = 292; triple dose, n = 111) or interval from the first inoculation to FET (< 3 months, n = 51; 3 ~ 6 months, n = 101; > 6 months, n = 306). The primary outcome was live birth rate (LBR). The LBR (43.87% vs. 40.57%) was not significantly different between the vaccinated and unvaccinated groups, and so were embryo implantation rate (IR), clinical pregnancy rate (CPR), the gestational age at delivery and birth weight (P > 0.05). IR was significantly decreased with the shorter interval of vaccination (28.57% vs. 32.02% vs.45.24%, P = 0.007), while LBR and CPR were not significantly different (P > 0.05). For the dose subgroups of vaccination, IR, LBR and CPR were not significantly different (P > 0.05). Inoculation of inactivated COVID-19 vaccine did not affect the outcome of FET. Clinical Trial Registration Number: ChiCTR2200055597 (Chinese Clinical Trial Registry), January 14, 2022. (https://www.chictr.org.cn/bin/project/edit?pid=148312)
A Qualitative Research on the Control Status and Needs of Hypertension Patients in Guangxi Region
Authors: ZHONG Yingqi , LIU Zhaopeng , DING Xifeng , ZHENG Jinghui
Published: December 2024

Objective
Understanding the current status and needs of hypertension patients in the Guangxi region to provide a reference for clinical diagnosis and treatment by medical staff.
Methods
Using purposeful sampling, 16 hypertension patients treated at a Class III Grade A integrated traditional Chinese and Western medicine hospital in Nanning City, Guangxi Zhuang Autonomous Region from March to July 2024 were selected as research subjects and semi-structured interviews were conducted. Data was analyzed using Colaizzi's 7-step analysis method in phenomenological research.
Results
The control status and needs of hypertension patients in the Guangxi region can be summarized into four themes：Psychological and social adaptation ( disease understanding and acceptance, treatment expectations and concerns, future planning and uncertainty ) ; medical needs and access ( hypertension-related knowledge of popular science, convenient medical needs, high-quality medical services needs, regular treatment needs, doctor-patient communication needs ) ; support system and resources ( family support, psycho-social support ) ; self-management and control ( lifestyle changes, treatment options, standardized monitoring and treatment ).
Conclusion Society should pay attention to the control status and needs of hypertension patients, provide support to patients from multiple aspects and dimensions, reduce the incidence of adverse events, and improve the quality of life for patients.
Ligands from Propolis as Antioxidants through Inhibition of Xanthine Oxidase (XOD): An In Silico Exploration.
Authors: Adeyanju Muinat Moronke , Omirin Emmanuel Sunday , Adelokiki Ibukunoluwa Folasade , Aribisala Precious Oluwasanmi , Odubela Olukayode Olusola
Published: December 2024

Excessive reactive oxygen species (ROS) contribute to various chronic diseases, and xanthine oxidase (XOD) is a significant source of ROS in human metabolism. Propolis, known for its antioxidant properties, contains bioactive compounds that may inhibit XOD and reduce ROS production. This study aimed to investigate the inhibitory potential of propolis-derived phytochemicals on XOD through in silico methods. We conducted molecular docking to assess binding affinities and interaction profiles of 48 propolis compounds with XOD’s active site. Key XOD interacting residues including Glu802, Arg880, Thr1010, and Glu1261 played a role in stabilizing the binding of lead compounds through hydrogen bonds and hydrophobic contacts. Compounds luteolin, apigenin, and acacetin exhibited high docking scores of -11.650, -11.470, and − 11.284 kcal/mol, respectively, indicating strong binding affinity than the common standards, febuxostat (-7.922 kcal/mol) and allopurinol (-5.707 kcal/mol). MMGBSA calculations supported these findings, with catechin, myricetin, and hesperetin showing favorable binding free energies of -53.48, -48.69, and − 48.40 kcal/mol. QSAR modeling further confirmed the inhibitory potential, with low IC50 values for the most active compounds. ADME-T analysis indicated high gastrointestinal absorption and favorable drug-likeness for several compounds, suggesting promising pharmacokinetic and pharmacodynamic properties. In conclusion, propolis compounds, particularly luteolin, apigenin, and acacetin, show significant potential as natural XOD inhibitors. These findings support further experimental validation of these compounds as antioxidant therapies for managing ROS-related diseases.
Identifying delayed neurological sequelae during the acute phase of carbon monoxide poisoning based on diffusion-weighted imaging and clinical features
Authors: Chen Siying , Yang Shijun , Tan Minghui , Lu Heying , Li Huan , Li Jinlan , Yang Xiuqiong , Huang Yanzhi , Tian Senbiao , Liu Qunhui
Published: December 2024

Background
Delayed neurological sequelae (DNS) represents a critical and potentially fatal complication. Therefore, the timely recognition of individuals at risk of developing DNS in early phase holds significant clinical value. This study aims to identify diffusion-weighted imaging (DWI) characteristics related to developing DNS, and construct a predictive model encompassing DWI characteristics and clinical variables to early prediction of DNS during the acute phase of carbon monoxide (CO) poisoning.
Methods
We retrospectively include 120 poisoned patients with newly diagnosed with CO poisoning. The subjects were divided into non-DNS group (n = 75) and DNS group (n = 45) after at least 60-day follow-up. The fractional anisotropy value and mean diffusivity value were measured in the regions of interest placed on the amygdala, caudate, hippocampus, pallidus, putamen, thalamus and ventricle. A support vector machine (SVM) model integrated both DWI and clinical features was developed and evaluated. And mean impact value was used to rank the features that had impacts on classification.
Results
A total of 24 clinical features and 28 DWI features were included. 8 clinical features and 23 DWIs were included in the SVM model. Three SVM models were established based solely on clinical features or DWI features, and combined clinical and DWI features, with prediction accuracy of 0.76, 0.94, and 0.97, respectively. The precision, sensitivity, F1 score, macroscopic mean, weighted mean, and AUC of the combined model is 1.00, 0.92, 0.96, 0.98, 0.97, 0.97, respectively, and the result of 10-flod cross validation was 0.98. The mean fractional anisotropy of left caudate had the highest impact on the SVM model.
Conclusions
The fractional anisotropy and mean diffusivity of DWI may be a potential biomarker in identifying patients at risk of developing DNS. Our comprehensive SVM model with multimodal features had excellent accuracy and clinical practicability in identifying DNS.
Development of a quantitative PMA-16S rRNA gene sequencing workflow for absolute abundance measurements of seawater microbial communities
Authors: Thomas Marie C. , Waugh Gretel , Damjanovic Katarina , Vanwonterghem Inka , Webster Nicole S. , Negri Andrew P. , Luter Heidi M.
Published: December 2024

Background
Ecological risk assessments rarely consider the impacts of environmental stress on microbial communities. The incorporation of microbial community responses into these evaluations requires establishing sensitivity thresholds based on the absolute abundance of viable taxa. While essential for describing microbial community dynamics, sequencing-based analyses are generally limited to assessing relative proportions and fail to reveal the magnitude or directionality of abundance shifts. To address this, we developed and validated a workflow combining propidium monoazide (PMA) treatment, 16S rRNA gene amplicon sequencing, and quantitative microbiome profiling (QMP) to determine the absolute abundance of viable taxa in seawater microbiomes.
Results
Using natural seawater, microbial load estimates from droplet digital PCR (ddPCR) and flow cytometry (FC) correlated strongly for total and intact cell counts, confirming the suitability of both methods for normalising 16S rRNA gene amplicon sequencing data. Additionally, we demonstrated that PMA at concentrations of 2.5–15 µM effectively inhibited PCR amplification of DNA from membrane-compromised cells, reducing 16S RNA gene copies by 24–44% relative to untreated samples. Samples with known proportions of intact cells were generated by mixing heat-killed and natural seawater, enabling abundance assessments by normalising 16S rRNA gene amplicon sequencing data to intact cell loads estimated via ddPCR and FC. This approach facilitated detailed comparisons of the effects of QMP versus relative microbiome profiling (RMP) on alpha and beta diversity metrics and on relative and absolute amplicon sequence variant (ASV) abundance profiles. Unlike RMP, QMP captured significant shifts in the microbial community composition across samples with decreasing proportions of intact cells. Furthermore, RMP failed to detect abundance changes at ASV-level, while QMP revealed consistent abundance declines.
Conclusion
The PMA-16S rRNA sequencing workflow, coupled with QMP, enhanced the accuracy in representing microbial community dynamics by addressing key limitations of RMP such as the inclusion of damaged cells or extracellular DNA and the misleading proportions of identified taxa. This workflow is particularly suited for quantifying the magnitude and direction of changes in taxa abundance following stress exposure, making it directly applicable to stress-response modelling and supporting the integration of microbial sensitivity thresholds into future regulatory guidelines.
Identification of the ferroptosis-related genes in Sepsis- Associated Encephalopathy by multiple transcriptional datasets analysis
Authors: Xie Zhefan , Zhang Wei , Li Lingfeng , Luo Ming , Chen Jialong , Gong Liya , Cao Jingjing , Liu Ye , Liu Jiean , Fu Chunlai
Published: December 2024

Sepsis associated encephalopathy (SAE), a severe sepsis complication, remains challenging to treat due to limited effective options. Current therapies focus on symptomatic relief and managing complications, without addressing the underlying causes, highlighting the need for further research. The condition's complex pathophysiology involves inflammation, blood-brain barrier disruption, and neuronal damage, necessitating a comprehensive understanding of its mechanisms through multi-dataset research. We used RNA sequencing, Mendelian randomization, and bioinformatics to study gene changes in SAE. Our analysis identified 1,259 differentially expressed genes related to inflammatory and bacterial responses. Mendelian randomization revealed 20 key genes, including ITPA and IL18R1, associated with sepsis risk. GSVA and GSEA analyses validated their roles in signaling pathways. Single-cell analysis showed gene expression across cell types and co-expression with ferroptosis-related genes. We also constructed regulatory and miRNA networks, identifying several transcription factors and miRNAs involved in gene regulation. Our multi-omics approach offers new insights into the molecular mechanisms of SAE and identifies potential therapeutic targets for this condition.
Determination of Natural Radionuclide Activity Concentrations and Radiological Hazards Assessment in the Bukit Karang Putih Mine Area of PT Semen Padang
Authors: Aj Aulia Fitri , Fardela Ramacos , Iskandar Dadong , Ladira Maulani Ruby , Annisa Emilia
Published: December 2024

Abstrak A study was conducted to determine the activity concentration of radionuclides 226Ra (Radium), 232Th (Thorium), and 40K (Potassium) and the radiological hazard index in the form of the rate of absorbed radiation dose and annual effective dose for workers in the Bukit Karang Putih mining area of PT Semen Padang using a gamma spectrometer. The samples measured were soil and water. The results of the study revealed that the quantities of radionuclides 226Ra, 232Th, and 40K were exclusively detected in soil samples, while the values obtained in water samples were below the MDC. Soil samples with the Soil 3 code obtained also contained radionuclides 232Th and 40K that were below the MDC. The average activity concentration of radionuclide 226Ra is 93,67 ± 13,52 Bq/kg, while that of 232Th is 221,63 ± 31,05 Bq/kg. The average activity concentration of 40K is 527,25 ± 75,13 Bq/kg. The activity concentration of radionuclides obtained is still below the intervention value established by PERKA BAPETEN No. 9 of 2009. However, the value in soil samples for 226Ra and 232Th is higher, and the value for 40K is lower, in comparison to the world average reported by UNSCEAR in 2000. The radiological hazard index value in soil samples for the absorbed radiation dose rate was obtained with an average of 200,573 nGy/hour, while for the annual effective dose the average value obtained was 0,2460 mSv/year. The value of the absorbed radiation dose rate and the annual effective dose in the air samples cannot be calculated because the activity concentration values obtained in the air samples have values below the MDC. The annual effective dose obtained is less than the limit established by ICRP and PERKA BAPETEN No. 4 of 2013, which is 1 mSv/year.
Surface profile estimation in milling through vibration analysis and long short-term memory networks
Authors: Wu Tian-Yau , Lin Cheng-Yi
Published: December 2024

The objective of this research is to investigate the feasibility of utilizing tooling vibration signals and cutting parameters to predict workpiece surface profiles in the milling process, enabling a comprehensive evaluation of surface quality. Information-contained (IC) signals were synthesized from milling vibration measurements using principal component analysis (PCA) and empirical mode decomposition (EMD). Statistical features and sweeping-frequency features were then extracted from individual intrinsic mode functions (IMFs) of the IC signals in both time and frequency domains. Subsequently, independent long short-term memory (LSTM) networks were used to estimate the individual IMFs of the surface profiles, incorporating the milling parameters and selected signal features as inputs. Results demonstrated that mid-low frequency components of surface profiles could be estimated accurately with an average mean absolute percentage error (MAPE) of 14.72%, while low-frequency components achieved an average MAPE of 7.79%.