bluuebunny/crossref_metadata_2025 huggingface dataset:
A Molecular-Level Mechanistic Framework for Interfacial Proton Coupled Electron Transfer Kinetics
Authors: Lewis Noah , Bisbey Ryan , Westendorff Karl , Soudackov Alexander , Surendranath Yogesh
Published: May 2023

Electrochemical proton coupled electron transfer (PCET) reactions are critical to energy conversion and catalysis. These reactions can be driven by outer-sphere electron transfer to a soluble molecule (OS-PCET) or through an inner-sphere mechanism by interfacial polarization of a surface-bound active site (I-PCET). The pH-dependent kinetics of OS-PCET have been extensively studied at the molecular level, but the inherent heterogeneity of most surfaces has impeded molecular-level understanding of I-PCET. Herein, we employ graphite conjugated carboxylic acids (GC COOH) as molecularly well-defined hosts of I-PCET to isolate the intrinsic pH dependent kinetics of this reaction. Using variable scan rate voltammetry, we measure the rates of I-PCET across the entire pH range and find a pronounced “V”-shaped dependence on pH with a rate minimum at pH 10 that rises log-linearly to pH 0 and pH 14. This kinetic profile spans three orders of magnitude in rate and lacks the pH-independent regions characteristic of electrochemical OS-PCET reactions. To explain these trends, we develop a mechanistic model for I PCET that invokes CPET involving hydronium/water or water/hydroxide donor-acceptor pairs. This relatively simple model captures the entire data set with only four adjustable parameters corresponding to the standard rate constants and charge transfer coefficients of the two donor/acceptor couples. From this analysis, we find that I PCET with water/hydroxide is four-fold more sluggish than with hydronium/water, but both reactions display similar charge transfer coefficients near 0.7, indicating a late transition state. These studies highlight the key mechanistic and kinetic distinctions between OS PCET and I-PCET and provide a baseline framework for understanding and modeling more complex I PCET reactions critical to energy conversion and catalysis.
The designed synthesis, recognition, and possible applications of Zn(III) complex
Authors: Sathapat Dibyendu , Das Mainak , Das Manik , Das Uttam Kumar , Laha Soumik , Roy Partha Pratim , Samanta Bidhan Chandra , Pathak Amrita , Bag Arijit , Maity Tithi
Published: May 2023

The structural pressure-induced ionization process is implemented to produce Zn(III) complex for the first time and possible potential applications for technological advances are reported in this article. The inversion of the electron population observed at the ground state of the newly synthesized complex corroborates an unexplored material response property towards electrical and magnetic fields. The first-time report of a true transition metal behavior of zinc fetches new thoughts about zinc-based bio-enzymatic and bio-catalytic processes along with its material applications in untouched files like live cell imaging contrast agents, photocatalytic water splitting, etc. The methodology of the ‘ structural pressure-induced ionization process’ may be implemented for the synthesis of more unusual oxidation states of metals.
The UniDec Processing Pipeline for Rapid Analysis of Biotherapeutic Mass Spectrometry Data
Authors: Phung Wilson , Bakalarski Corey , Hinkle Trent , Sandoval Wendy , Marty Michael
Published: May 2023

Recent advances in native mass spectrometry (MS) and denatured intact protein MS have made these techniques essential for biotherapeutic characterization. As MS analysis has increased in throughput and scale, new data analysis workflows are needed to provide rapid quantitation from large datasets. Here, we describe the UniDec Processing Pipeline (UPP) for the analysis of batched biotherapeutic intact MS data. UPP is built into the UniDec software package, which provides fast processing, deconvolution, and peak detection. The user and programming interfaces for UPP read a spreadsheet that contains the data file names, deconvolution parameters, and quantitation settings. After iterating through the spreadsheet and analyzing each file, it returns a spreadsheet of results and HTML reports. We demonstrate the use of UPP to measure correct pairing percentage on a set of bispecific antibody data and to measure drug-to-antibody ratios from antibody-drug conjugates. Moreover, because the software is free and open-source, users can easily build on this platform to create customized workflows and calculations. Thus, UPP provides a flexible workflow that can be deployed in diverse settings and for a wide range of biotherapeutic applications.
Targeting RdRp of SARS-CoV-2 with de novo molecule generation
Authors: Vijay Amal , Adury Venkata Sai Sreyas , Mukherjee Arnab
Published: May 2023

Viruses are known for their extremely high mutation rates, allowing them to evade both the human immune system and many forms of standard medicine. Despite this, the RNA Dependent RNA Polymerase (RdRp) of the RNA viruses has been largely conserved, and any significant mutation to this protein is unlikely. The recent COVID-19 pandemic presents the need for novel therapeutics. We have designed a de novo drug design algorithm that generates strong binding ligands from scratch, based only on the structure of the target protein’s receptor. In this article, we applied our method to target SARS-CoV-2 RdRp and generated several de novo molecules. We then chose some drug molecules based on the structural similarity to some of our strongest binding de novo molecules. Subsequently, we showed, using rigorous all-atom explicit-water free energy calculations in near-microsecond timescales using state-of-the-art well-tempered metadynamics simulations, that some of our de novo generated ligands bind more strongly to RdRp than the recent FDA approved drug Remdesivir in its active form, remdesivir triphosphate (RTP). We elucidated the binding mechanism for some of the top binders and compared with RTP. We believe that this work will be useful both by presenting newer lead structures for RdRp inhibition and by delivering key insights into the residues of the protein potentially involved in the binding/unbinding of these small molecule drugs, leading to more targeted studies in the future.
Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and disease
Authors: Umerenkov Dmitry , Herbert Alan , Konovalov Dmitrii , Danilova Anna , Beknazarov Nazar , Kokh Vladimir , Fedorov Aleksandr , Poptsova Maria
Published: May 2023

Identifying roles for Z-DNA remains challenging given their dynamic nature. Here, we perform genome-wide interrogation with the DNABERT transformer algorithm trained on experimentally identified Z-DNA forming sequences (Z-flipons). The algorithm yields large performance enhancements (F1 = 0.83) over existing approaches and implements computational mutagenesis to assess the effects of base substitution on Z-DNA formation. We show Z-flipons are enriched in promoters and telomeres, overlapping quantitative trait loci for RNA expression, RNA editing, splicing, and disease-associated variants. We cross-validate across a number of orthogonal databases and define BZ junction motifs. Surprisingly, many effects we delineate are likely mediated through Z-RNA formation. A shared Z-RNA motif is identified in SCARF2, SMAD1, and CACNA1 transcripts, whereas other motifs are present in noncoding RNAs. We provide evidence for a Z-RNA fold that promotes adaptive immunity through alternative splicing of KRAB domain zinc finger proteins. An analysis of OMIM and presumptive gnomAD loss-of-function datasets reveals an overlap of Z-flipons with disease-causing variants in 8.6% and 2.9% of Mendelian disease genes, respectively, greatly extending the range of phenotypes mapped to Z-flipons.
Book masterpieces of Mykola Semenovych Samokysh in the Central Scientific Library Karazin University
Authors: Prots Natalia
Published: May 2023

The article analyzes the illustrated book editions of the cultural and artistic heritage of the outstanding Ukrainian artist Mykola Semenovych Samokysh, which are stored in the Central Scientific Library.

The purpose of the study is to study and disclose books and periodicals illustrated by the artist M. S. Samokish. The artist's paintings are stored in many museum collections in Ukraine and Russia and in galleries of various collectors, and graphic works, books and magazines decorated with artistic illustrations enrich the funds of many libraries. The Central Scientific Library of Karazin University preserves unique editions of the artist, which are currently a bibliographic rarity.

The methodological basis of the study is the problem-chronological method, which allowed to trace the sequence of origin, formation and development of creative activity of M. S Samokish. This method allowed to study and analyze a specific creative work of an illustrator in a certain period of time.

The scientific novelty of the research lies in the coverage of book-illustrative publications from the fund of the Central Scientific Library. This allows you to popularize the library fund as a whole and determines its scientific, cultural and historical value. A specific bibliological study reveals the personal contribution of M. S. Samokysh to the development of book art in Ukraine.

Conclusions. M. S. Samokysh is known, above all, as an excellent master of the battle genre, for which he was awarded silver and gold medals and awarded the title of Academician of the Academy of Arts.

Also, it should be noted that M. S. Samokysh took part in the preparation and creation of albums on Ukrainian art. This is a famous art publication "From Ukrainian antiquity" in 1900 and a rare album "Motives of Ukrainian ornament", which was published in the early XX century.

The vast majority of Samokish's works were performed in his favorite battle genre. Thus, the result of Nikolai Semenovich's trip to the front of the Russo-Japanese War was the album "War 1904-1905: From the Diary of an Artist" published in 1908. . The magazine "The Great War in Images and Pictures 1914–1915" of 1915 included the artist's front-line materials. Drawings and watercolors from nature, made directly on the fronts, serve as a kind of historical document of the turbulent war years.

Of particular interest are the many illustrated books on the history of the royal army, military regiments, the coronation of the royal family and others. The historical essay on the history of the Grand Ducal and tsarist hunts in Russia and Russia is fascinating. A multi-volume study of individual regions of the Russian Empire at the end of the XIX century is quite significant.

Artistic and graphic elements of book decoration - vignettes, letters, screensavers, endings, which worked on the painter and graphic artist M. S. Samokish, not only reveal and supplement the content of books, but also make publications real works of art.
La consulta popular en Tauramena, Casanare. “Yo estoy dispuesto a sudar petróleo en defensa del agua”
Authors: Arias Perales Ildefonso , Contreras Castillo Alejandro
Published: May 2023

La consulta popular llevada a cabo en el municipio de Tauramena en el departamento del Casanare, se sitúa en el conflicto socioambiental originado por la adjudicación de un bloque de exploración sísmica a la empresa Ecopetrol por parte de la Agencia Nacional de Hidrocarburos (ANH), el cual se denominaba “Área adicional de exploración sísmica Odisea 3D”. La actividad de explotación petrolera se desarrollaría en un área que afectaba las zonas de recarga hídrica de este municipio y otros como Aguazul, Recetor, Chámeza y Monterrey, ubicados en el pie de monte llanero.
Las consultas populares de Arbeláez y Fusagasugá, Cundinamarca. “Suma agua, suma vida, suma paz”
Authors: García Acelas Marisabel , Quintero Leguizamón Robert Adrián
Published: May 2023

En el marco de la disputa geopolítica por el control estratégico de recursos energéticos y ante la elevada demanda de abastecimiento de materias primas para el creciente mercado chino, se ha ampliado la extracción de minerales y energéticos provocando de forma concomitante la movilización de organizaciones y movimientos sociales que impugnan la degradación de las condiciones ecosistémicas que garantizan la vida y sustentabilidad de los territorios (Svampa y Slipak, 2015). Las consultas popularesllevadas a cabo en los municipios de Arbeláez y Fusagasugá impugnaron los efectos territoriales de las políticas dominantes del modelo económico-productivo, particularmente proyectados sobre el páramo del Sumapaz, apoyándose en repertorios comunicacionales con enorme capacidad de convocatoria. Palabras clave: páramo del Sumapaz, Arbeláez, Fusagasugá, repertorios comunicacionales, participación.
Chaos and bifurcation of discontinuous dynamical systems with piecewise constant arguments
Authors: A.M.A. El-Sayed  , S. M. Salman
Published: May 2023

In this paper we are concerned with the definition and some properties of the discontinuous dynamical systems generated by piecewise constant arguments. Then we study a discontinuous dynamical system of the Riccati type equation as an example. The local stability at the fixed points is studied. The bifurcation analysis and chaos are discussed. In addition, we compare our results with the discrete dynamical system of the Riccati type equation.
Existence and stability for fractional order integral equations with multiple time delay in Fr´echet spaces
Authors: Said Abbas  , Mouffak Benchohra
Published: May 2023

In this paper, we present some results concerning the existence of solutions for a system of integral equations of Riemann-Liouville fractional order with multiple time delay in Fr´ echet spaces, we use an extension of the Burton-Kirk fixed point theorem. Also we investigate the stability of solutions of this system.
Existence results for neutral functional fractional differential equations with state dependent-delay
Authors: Velusamy Kavitha  , Peng-Zhen Wang  , R. Murugesu
Published: May 2023

In this paper, we provide sufficient conditions for the existence of mild solutions for a class of fractional differential equations with state-dependent delay. The results are obtained by using the nonlinear alternative of Leray-Schauder type [14] fixed point theorem. An example is provided to illustrate the main results.
On some integral inequalities using Hadamard fractional integral
Authors: Vaijanath L. Chinchane  , Deepak B. Pachpatte
Published: May 2023

In this paper, using Hadamard fractional integral, we establish two main new result on fractional integral inequalities by considering the extended Chebyshev functional in case of synchronous function. The first result concerns with some inequalities using one fractional parameter and other with two parameter.
On a nonlinear functional second order integrodifferential equation in Banach Spaces
Authors: P. M. Dhakane  , D. B. Pachpatte
Published: May 2023

In this paper, we study the existence, uniqueness and other properties of solutions of a nonlinear functional second order Volterra integrodifferential equation in a general Banach space. The techniques used in our analysis are the theory of the strongly continuous cosine family, Schauder fixed point theorem and Pachpatte’s integral inequality.
Oscillation results for third order nonlinear neutral differential equations of mixed type
Authors: Ethiraju Thandapani  , Renu Rama
Published: May 2023

Some oscillation results are obtained for the third order nonlinear mixed type neutral differential equations of the form$$\left(\left(x(t)+b(t) x\left(t-\tau_1\right)+c(t) x\left(t+\tau_2\right)\right)^\alpha\right)^{\prime \prime \prime}=q(t) x^\beta\left(t-\sigma_1\right)+p(t) x^\gamma\left(t+\sigma_2\right), t \geq t_0$$where $\alpha, \beta$ and $\gamma$ are ratios of odd positive integers $\tau_1, \tau_2, \sigma_1$ and $\sigma_2$ are positive constants.
Relative controllability of fractional stochastic dynamical systems with multiple delays in control
Authors: Toufik Guendouzi  , Iqbal Hamada
Published: May 2023

This paper is concerned with the global relative controllability of fractional stochastic dynamical systems with multiple delays in control for finite dimensional spaces. Sufficient conditions for controllability results are obtained using Banach fixed point theorem and the controllability Grammian matrix which is defined by the Mittag-Leffler matrix function. An example is provided to illustrate the theory.
Antioxidant, antimicrobial and some chemical composition of Plagiochila asplenioides (L.) Dumort extract
Authors: OKAN Onur Tolga
Published: May 2023

Bryophytes are the oldest terrestrial plants in the world, about 3000 taxon are known to have medicinal properties. Plagiochila asplenioides (L.) Dumort, which is one kind of bryophytes, was examined in this study. The antimicrobial, antioxidant, fatty acids, mineral analysis and some chemical properties of the extracts obtained from the bryophyte were investigated. It was determined that the P. asplenioides extract had a moderate effect in terms of antioxidant properties and total phenolic content. In terms of fatty acid compositions, oleic and palmitic acid were found to be high. As a result of the mineral analysis, it has been observed that it can accumulate high levels of potassium (K), calcium (Ca), iron (Fe) and aluminum (Al). In addition, it was observed that the extracts obtained from P. asplenioides showed only a moderate inhibitory effect against Escherichia coli and Salmonella typhimurium.
Prolonged grief disorder: Nature, risk-factors, assessment, and cognitive-behavioural treatment
Authors: Boelen Paul
Published: May 2023

Most people who are confronted with the death of a loved adjust without needing professional help. A significant minority of people confronted with loss develops symptoms of prolonged grief disorder (PGD), sometimes accompanied by bereavement-related post-traumatic stress disorder (PTSD) and depression. PGD is newly included in the psychiatric classification systems of the ICD-11 and DSM-5-TR. In Ukraine, many people are currently facing losses, in circumstances that may render them vulnerable to develop PGD and associated symptoms. In this article, we address “healthy” grief and discuss the nature, assessment, risk factors, and treatment of “unhealthy” grief, now referred to PGD. We also introduce a cognitive behavioural theory that helps to understand problematic psychological processes involved in the persistence and maintenance of PGD and that offers a clear framework for the application of all kinds of cognitive behavioural interventions and other treatment interventions that can be used to alleviate the pain of people with PGD. Examples of these interventions are described. Attention is paid to how the situation of war affects the development and treatment of PGD.
PRESENT WAR IN UKRAINE EXISTENTIAL CRISIS OF YOUTH
Authors: Sachko Katerina
Published: May 2023

These graphic materials are a poster presentation for the III Congress with international participation "PSYCHOSOMATIC MEDICINE OF THE XXI CENTURY: REALITIES AND PERSPECTIVES". Which took place on November 4-6, 2022 in Kyiv on the Mediamed portal.
Issues of mental health due to the state of war in Ukraine
Authors: Sodolevska Valeria
Published: May 2023

These graphic materials are a poster presentation for the III Congress with international participation "PSYCHOSOMATIC MEDICINE OF THE XXI CENTURY: REALITIES AND PERSPECTIVES". Which took place on November 4-6, 2022 in Kyiv on the Mediamed portal.
CLINICAL PHENOMENOLOGY OF PSYCHOGENIC CHOKE
Authors: Haichuk Larisa
Published: May 2023

These graphic materials are a poster presentation for the III Congress with international participation "PSYCHOSOMATIC MEDICINE OF THE XXI CENTURY: REALITIES AND PERSPECTIVES". Which took place on November 4-6, 2022 in Kyiv on the Mediamed portal.
A MULTIMODAL APPROACH TO THE THERAPY OF POST-STRESS DISORDERS IN THE CONDITIONS OF A FULL-SCALE INVASION
Authors: Zelenska K
Published: May 2023

These graphic materials are a poster presentation for the III Congress with international participation "PSYCHOSOMATIC MEDICINE OF THE XXI CENTURY: REALITIES AND PERSPECTIVES". Which took place on November 4-6, 2022 in Kyiv on the Mediamed portal.
SPECIFICITY OF MENTAL DISORDERS IN PATIENTS WITH TYPE II DIABETES
Authors: Kondratenko Anastasia
Published: May 2023

These graphic materials are a poster presentation for the III Congress with international participation "PSYCHOSOMATIC MEDICINE OF THE XXI CENTURY: REALITIES AND PERSPECTIVES". Which took place on November 4-6, 2022 in Kyiv on the Mediamed portal.
SUPPORTING THE MENTAL HEALTH OF PATIENTS AFTER COVID 19
Authors: Leshina Irina
Published: May 2023

These graphic materials are a poster presentation for the III Congress with international participation "PSYCHOSOMATIC MEDICINE OF THE XXI CENTURY: REALITIES AND PERSPECTIVES". Which took place on November 4-6, 2022 in Kyiv on the Mediamed portal.
MEDICAL AND PSYCHOLOGICAL SUPPORT OF PARTICIPANTS OF COMBAT ACTIONS WHO RECEIVED WOUNDS
Authors: Platinyk Oksana
Published: May 2023

These graphic materials are a poster presentation for the III Congress with international participation "PSYCHOSOMATIC MEDICINE OF THE XXI CENTURY: REALITIES AND PERSPECTIVES". Which took place on November 4-6, 2022 in Kyiv on the Mediamed portal.
Pengaruh Produk Pembiayaan BMT terhadap Usaha Mikro Nasabah
Authors: Nurhidayati Islamiah  , A. Nur Achsanuddin
Published: May 2023

This study aims to determine the effect of Mudharabah and Murabahah financing products on the increase in micro-businesses of customers in Makassar. This type of research used in this research is quantitative. The data processed is mudharabah and murabahah financing customers obtained from Baitul Ma Wat Tamwil Multi Jasa Sejahtera City of Makassar. The analysis technique used in this research is the simple regression analysis technique. to determine the effect of the independent variable on murabahah financing on the dependent variable on the development of SMEs and the independent variable for the independent variable on the independent variable for the development of SMEs which were tested separately. Based on the results of data processing, it shows that murabahah and mudharabah financing has a positive influence on the development of SME customers of BMT Multi Jasa Sejahtera.
Analisis Penggunaan Aplikasi Siskeudes Dalam Pengelolaan Keuangan di Desa Belapunranga Kec. Parangloe Kab. Gowa Sulawesi Selatan
Authors: Ayu Auliyah  , Samirah Dunakhir
Published: May 2023

This study aims to determine how well the use of the Siskeudes Application in Financial Management in Belapunranga Village, Kec. Parangloe Kab. Gowa, South Sulawesi. The variable in this study is the use of the Siskeudes Application in Financial Management as measured by Permendagri Number 20 of 2018 concerning Financial Management. The population of this research is Financial Management in Belapunranga Village, Kec. Parangloe Kab. Gowa, South Sulawesi, while the sample in this study used Financial Management Results for the 2021 Fiscal Year. Data collection was carried out using documentation, while the data analysis technique used was descriptive analysis using a rough conformity index measurement. The results showed that the overall use of the Siskeudes Application in Financial Management with 5 indicators namely planning, implementation, administration, reporting, and accountability can still be said to be quite appropriate/good enough with a percentage of 73% from 100%.
Pengembangan Usaha Berbasis Digital Pada Masa Pandemi Covid-19
Authors: Nurjannah
Published: May 2023

This study aims to determine the development of digital-based businesses during the Covid-19 pandemic. This study used a qualitative approach and descriptive method. The data collection used was an interview technique. Informants were determined by purposive sampling technique with certain criteria, so that there were 2 respondents in this study who were sellers of digital-based processed ice lolly. The data analysis phase carried out in this study consisted of data reduction, then data presentation. And the next data analysis is to draw conclusions on the information that has been obtained.
Analisis Stategi Pemasaran Jasa Menghadapi Pesaing Terhadap Usaha Laundry (QNC Laundry Toddopuli)
Authors: Andi Sawe Riesso  , Nurlaila Syarfiah Asfo  , Suharto
Published: May 2023

This study aims to analyze the effect of people's income, interest rates and inflation on savings in Indonesia. The independent variables in this study are people's income, interest rates and inflation, while the dependent variable is the amount of savings. The population in this study is data on public income, interest rates and inflation, while 15 samples were used, namely from 2005 to 2019. The research data was obtained from publications from the Central Bureau of Statistics (BPS) and Bank Indonesia. The data analysis technique used is multiple linear regression analysis. Based on the results of data analysis conducted in this study, it can be concluded that: (1) people's income has a positive effect on saving in Indonesia; (2) interest rates and inflation have no effect on savings in Indonesia.
МЕТОДИКА ОЦЕНКИ СОДЕРЖАНИЯ ПЛАНАРНЫХ ДЕФЕКТОВ В СТРУКТУРАХ A2BO4 РЯДА РАДДЛЕСДЕНА-ПОППЕРА НА ПРИМЕРЕ Sr2TiO4
Authors: Горкуша А.С. , Цыбуля С.В. , Черепанова С.В. , Шмаков А.Н. , Павлова С.Н.
Published: May 2023

Разработана методика оценки содержания дефектов чередования слоев в структурах типа А2BO4 гомологического ряда Раддлесдена-Поппера, основанная на анализе соотношения определенных межплоскостных расстояний. Калибровочные графики построены по результатам расчета дифракционных картин на основе вероятностной модели одномерно разупорядоченных кристаллов при различной концентрации дефектов. Тестирование методики выполнено на образцах Sr2TiO4 с использованием данных синхротронного эксперимента.
15-Металлакрауны-5 на основе легких лантаноидов: топология электронной плотности и ЯМР распознавание энантиомеров манделат-аниона
Authors: Жигулин Г.Ю. , Каткова М.А. , Муравьева М.С. , Забродина Г.С. , Баранов Е.В. , Маркин Г.В. , Кетков С.Ю.
Published: May 2023

Систематически исследовано влияние связывания манделат-аниона C6H5CH(OH)COO− (MA) с 15-металлакраунами-5 (15-MC-5) на ЯМР сигнал протона при хиральном атоме углерода MA. Ряд рассмотренных 15-MC-5 включает полиядерные гетерометаллические комплексы La(III)–Cu(II), Ce(III)–Cu(II), Pr(III)–Cu(II) и Nd(III)–Cu(II) на основе глицин- (Glyha) и аланингидроксиматных (Alaha) лигандов. При этом комплекс состава Nd(H2O)4[15-MCCu(II)Alaha-5]∙3Cl впервые охарактеризован методом рентгеноструктурного анализа. В 1H ЯМР спектрах аланингидроксиматных комплексов расщепление сигнала протона при хиральном атоме углерода MA наблюдается для каждого из ионов La(III)–Nd(III). Особенности взаимодействия манделат-аниона с 15-MC-5 исследованы методами квантовой химии на примере аланингидроксиматного комплекса Nd(III).
Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)
Authors: Suhartati Tati , Sa’diah Khalimatus , Yandri Yandri , Hadi Sutopo
Published: May 2023

This research is a continuation of the successful isolation of artocarpin from the root of Artocarpus kemando Miq reported in our previous study. In the previous study, the artocarpin was characterized with UV-Vis and FTIR techniques. In this follow-up investigation, the artocarpin was subjected to a transesterification reaction using acetic anhydride and pyridine as catalysts, and the product of the reaction was specified as compound 1. The compound 1 was further characterized with different techniques to gain more complete data and then tested for anticancer activity test against P-388 murine leukemia cells. Characterizations of the compound 1 using 1H-NMR and 13C-NMR techniques suggest that the modification reaction resulted in the conversion of the -OH groups at C2' and 4' at the artocarpin molecule to -OOCH3, and based on the MS analysis, the compound was proposed to have the molecular formula of C30H32O8. Another important feature of compound 1 that should be noted is the significant improvement in stability compared to the unmodified artocarpin. Anticancer activity tests against P-388 murine leukemia cells revealed that compound 1 has an IC50of 2.35 g/mL, confirming that the compound is categorized as an active anticancer agent and suggesting that the compound has promising potential that deserves further investigations. Doi: 10.28991/ESJ-2023-07-03-05 Full Text: PDF
Perilaku Ibu Rumah Tangga dalam Memenuhi Kebutuhan Melalui Belanja Online di Kota Bukittinggi
Authors: Amelia Nadhifa Putri , Afrida Afrida , Meiyenti Sri
Published: May 2023

The objective of this study is to describe the purchasing behavior of household mothers in online stores to meet their needs, explain their understanding of information, perceptions, and decision-making processes in utilizing technology, and describe the factors that influence consumer decisions in online shopping. This study utilizes qualitative research methods with data collection techniques of observation, interviews, and documentation. The results of the study indicate that there are four factors that influence the behavior of household mothers as consumers in online shopping, namely price, quality, convenience, and time. From these online shopping activities, the information and understanding obtained by household mothers in utilizing technology include knowledge about products, purchasing procedures, and satisfaction. The perceptions of household mothers in utilizing technology include ease, practicality, security, and comfort in shopping. The factors that influence the decision-making of household mothers as online consumers include health and psychological factors, influences from family members, neighbors, and relatives, as well as advertising.Abstrak: Tujuan penelitian ini adalah untuk mendeskripsikan perilaku konsumen ibu rumah tangga terhadap keputusan pembelian di toko online dalam memenuhi kebutuhannya; menjelaskan pemahaman informasi, persepsi, dan proses pengambilan keputusan oleh konsumen dalam memanfaatkan teknologi; dan mendeskripsikan faktor-faktor yang mempengaruhi keputusan konsumen dalam berbelanja online. Penelitian ini menggunakan metode penelitian kualitatif dengan teknik pengumpulan data observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa terdapat empat hal yang mempengaruhi perilaku ibu rumah tangga sebagai konsumen dalam berbelanja online yaitu harga, kualitas, kenyamanan, dan waktu. Dari kegiatan belanja online tersebut pemahaman informasi yang diperoleh ibu rumah tangga dalam memanfaatkan teknologi adalah pengetahuan tentang produk, cara membeli, dan kepuasan. Persepsi ibu rumah tangga dalam memanfaatkan teknologi kemudahan, praktis, keamanan dan kenyamanan dalam berbelanja. Adapun faktor-faktor yang mempengaruhi keputusan konsumen ibu rumah tangga dalam berbelanja online adalah faktor kesehatan, psikologis; dorongan dari anggota keluarga, tetangga dan kerabat, serta iklan.
CULTURAL COMPETENCE OF NURSE LEADERS IN HEALTHCARE ORGANIZATION FOR SUSTAINABLE DEVELOPMENT OF HEALTH INSTITUTIONS
Authors: Thiyagarajan Sharmila , Yadav Anil Prasad
Published: May 2023

Healthcare sector is a multidisciplinary approach especially in hospitals effective leadership also necessitates acknowledgement of circumstances nurses should realize that their leadership and cultural care is as important in providing quality care. Demographic changes reflect a multicultural population and increasing the diversity of the nation brings significant challenges in providing individualized and holistic care. Leadership requires the identification of desired change and is capable of encouraging others to instigate change. In order to increase the quality of care for patients, it is imperative that healthcare leaders recognize and grow the skills which are needed for the upcoming batch of nurse leaders. Recent trend, that has influenced nursing and health professional, concerning to focus on culturally competent care in intensive stress healthcare environments. Nursing and all health workers need to be trained in cultural competency; thus, this cultural competency education may minimize potential negative outcomes.
Wind turbine optimization through optimal blade shape design for low wind speeds
Authors: Tira H.S. , Juliawan Y. , Padang Y.A. , Nurpatria N.
Published: May 2023

Current electricity needs continue to rely on depleting fossil fuels such as fossil fuel and coal. The current government effort is to find non-fossil fuel alternative energy sources. Wind energy is one of the efforts to use ecologically friendly renewable alternative energy. Studies on the development and use of new and renewable energy are now undertaken. One of them is a series of research on the utilization of wind in numerous places of Indonesia through the construction of wind turbines. The blade that explicitly makes contact with the wind is one of the most critical sections of a wind turbine. The shape of the airfoil determines whether or not the blade is used. The focus of this research was to determine the optimal type of airfoil by comparing the coefficient of power (Cp), maximum power, and lowest power produced by various NACA (National Advisory Committee for Aeronautics) airfoils. NACA 4410, 4412, and 4415 airfoils were employed in this study.
Konsep Penguatan Fungsi Legislasi Dewan Perwakilan Rakyat Republik Indonesia Pasca Amandemen UUD NRI Tahun 1945
Authors: Asmara Galang , Risnain Muh. , Zunnuraeni Zunnuraeni , Karyati Sri
Published: May 2023

Politik hukum fungsi legislasi DPR RI terdapat dalam konstitusi yang mengalami perubahan yang fundamental pasca amandemen. Fungsi legislasi yang sebelum diamandemen dipegang oleh presiden, setelah perubahan konstitusi kewenangan legislasi dimiliki oleh DPR. Perubahan kewenangan tidak saja dimaksudkan untuk terciptanya proses check and balance dalam proses pembentukan undang-undang, tetapi juga dihajatkan untuk menjawab kebutuhan pembangunan hukum nasional yang berkualitas.Pelaksanaan fungsi legislasi DPR RI setelah perubahan konstitusi tidak dapat dijalankan secara maksimal karena diindikasikan dengan minimnya produk legislasi dan tidak berkualitasnya undang-undang yang dihasilkan DPR.  Capaian legislasi yang tidak tercapai sesuai target legislasi dan banyaknya UU yang diajukan judicial review di MK menjadi tolok ukur pelaksanaa fungsi legislasi DPR RI.Konsep penguatan fungsi legislasi DPR RI dapat dilakukan dengan mereposisi Badan Legislasi DPR RI sebagai Law center , memperkuat Supporting system DPR RI, melakukan pembuatan blue print penguatan pelaksanaan fungsi legislasi DPR RI. Pelaksanaan fungsi legislasi DPR RI yang optimal harus didukung oleh kelembagaan pada alat kelengkapan DPR RI yang fungsional dan didukung oleh supporting system yang handal. Oleh karena itu DPR dan Presiden hendaknya mendesain kelembagaan dan supporting system pelaksanaan fungsi legislasi DPR RI dalam UU MD3.Kebijakan reposisi Badan Legislasi DPR RI sebagai Law center, memperkuat Supporting system DPR RI, melakukan pembuatan blue print penguatan pelaksanaan fungsi legislasi DPR RI hendaknya dilakukan DPR RI dengan melakukan perubahan terhadap UU MD3.
Aspek Hukum Pertanggung Jawaban Keuangan Negara Dalam BUMN
Authors: Asikin Zainal , Suhartana Lalu Wira Pria , Usman Usman
Published: May 2023

Penelitian ini bertujuan untuk menganalisis apakah Keuangan BUMN dan BUMD termasuk keuangan Negara yang jika terjadi kerugian Negara dalam BUMN dan BUMD dapat dipandang sebagai tindak pidana korupsi, dan Siapakah yang seharusnya bertanggung jawab terhadap BUMN dan BUMD jika mengalami kerugian dalam pengemlolannya?. Metode yang dipergunakan dalam penelitian ini adalah metode normatif dengan pendekatan perundang undangan dan pendekatan konseptuan. Hasil penelitian menunjukan bahwa keuangan BUMN dan BUMD dapat dikatorikan sebagai keuangan negara sehingga bagi pengurus perusahaan BUMN/BUMD dapat dijerat pada tindak pidana korupsi jika merugikan keuangan negara. Namun demikian disatu sisi ada yang memasukan kepada keuangan perusahaan yang tunduk pada UU No.40 Tahun 2017 tentang Perseroan Terbatas sehingga jika dapat dituntut secara keperdataan.
Model Perlindungan Hukum Bagi Anak Jalanan Terhadap Tindak Pidana Seksual Di Indonesia
Authors: Karyati Sri
Published: May 2023

Penelitian ini merupakan penelitian normative yan menitikberatkan pada kajian perundan-undangan dan bertujuan untuk mengkaji bagaimana pengaturan perlindungan hukum bagi anak jalanan terhadap kejahatan seksual dan model perlindungan hukum bagi anak jalanan terhadap kejahatan seksual.Sebagai subjek hukum, anak-anak harus mendapatkan perlakuan dan perlindungan yang sama dengan orang dewasa. Perlindungan terhadap anak-anak jalanan merupakan amanat yang terkandung dalam Pasal 34  Ayat (1)  UUD NRI tahun 1945. Jumlah anak jalanan makin meningkat dan hal ini diikuti oleh meningkatnya kejahatan yang dialami oleh anak-anak jalanan, khususnya kejahatan seksual. Dan jika dikaitkan dengan amanat konstitusi maka Pemerintah mempunyai kewajiban untuk menjadi pionir dalam hal mengurangi tingkat kejahatan seksual yang terjadi dikalangan anak-anak jalanan serta berkewajiban untuk melindungi hak-hak anak jalanan untuk tidak mendapat pelecehan seksual khususnya.
Implemetasi Hukum Lingkungan Internasional Dalam Hukum Nasional Indonesia
Authors: Pitaloka Diva
Published: May 2023

Hasil penelitian menyimpulkan dua hal hal, pertama, sistem hukum lingkungan internasional telah mengatur berbagai aspek di bidang lingkungan yaitu aspek perlindungan lingkungan laut, perlindungan atmosfer, perlindungan transportasi laut, dan Di Bidang Transportasi Bahan Beracun Berbahaya. Bidang-bidang tersebut telah meletakkan prinsip-prinsip dasar hukum lingkungan nasioanal yang diterapkan dalam hukum nasional masing-masing Negara anggota. Kedua, implementasi hukum lingkungan internasional ke dalam hukum nasional Indonesia dilakukan dengan mengatur dalam hukum nasional Indonesia antara lain dalam Undang-undang konservasi sumber daya hayati seperti UU No 32 Tahun 2009 tentang Perlindungan dan Pengelolaan Lingkungan Hidup, UU No 41 Tahun 1999 tentang Kehutanan, UU No 31 Tahun 2004 Tentang Perikanan dan UU No 27 Tahun 2007 tentang Pengelolaan Wilayah Pesisir dan Pulau Pulau Kecil. Undang-undang tersebut telah mengadopsi berbagai prinsip-prinsip hukum lingkungan internasional yang ada dalam berbagai perjnjain internasioanal.
Comparison of late oral feeding with early oral feeding after stoma reversal.
Authors: Abubakar Siddiqui  , Anwar Masood  , Muhammad Zeb  , Sabir Khan Khattak  , Azhat Hayat Khan  , Nasib Ali
Published: May 2023

Objective: To compare early and late oral feeding after ileostomy closure in terms of postoperative anastomotic leakage. Study Design: Randomized Control Trial. Setting: Department of Surgery Unit, Leady Reading Hospital Peshawar. Period: July 2020 to January 2021. Material & Methods: All patients with stoma 226 (113 in each group) were observed. Patients were randomly divided into two categories. In the early postoperative period (within 24 hours of surgery), Group A permitted oral feeding. Group B who preserved "nil by mouth" for up to 72 hours during the post-operative phase. Patients were held null by mouth in the post-operative phase, while intravenous antibiotics and fluids were listed in both groups for up to the duration. In group A within 24 hours and in group B after 72 hours, 30 ml of liquid per hour was started orally. Follow-up was taken after the 7th day post-operative. The frequency of anastomotic leakage between the two groups was assessed and safety was defined based on anastomotic leakage. Results: The mean age in Group A was 42 years SD ± 6.94 for this analysis, while the mean age in Group B was 44 years SD +6.15. In 90 % of patients, more than Group A (early oral feeding) was safe, whereas Group B (late oral feeding) was safe in 86% of anastomotic leakage patients. Conclusion: Our research concludes that early oral feeding is better in terms of anastomotic leaks compared to late oral feeding after ileostomy closure.
Arthroscopic evaluation of articular cartilage in knee injuries: A predictor of early osteoarthritis in young population.
Authors: Wasim Anwar  , Zeeshan Aziz  , Noor Rahman  , Sabir Khan Khattak  , Israr Ahmad  , Azhar Hayat Khan
Published: May 2023

Objective: To evaluate articular Cartilage after Knee injuries in young population as predictor of early Osteoarthritis, to pave the much more effective OA preventive measures in young population. Study Design: Descriptive Case Series. Setting: Department of Orthopedics, Hayatabad Medical Complex, Peshawar. Period: 2020 to 2021. Material & Methods: One hundred forty five patients was conducted in Early Osteoarthritis was defined as a diffuse and ill-defined involvement, but originated in the cartilage surrounding a focal lesion, considered to include a maximal involvement of 50% of the cartilage thickness (ICRS Grade II) based on the macroscopic ICRS classification. Articular cartilage evaluation (Chondral lesions and OA) were recorded on set proforma according to ICRS grading system. Results: Mean age was 32 years. Significant risk for early osteoarthritis was 17.9%; female had higher risk for early osteoarthritis as compared to male with p value of 0.03. Correlation between patient’s age and grade of chondral lesion with risk for early Osteoarthritis were significant with p value of 0.00 and .002 respectively. Significant risk for early osteoarthritis was 10.25%, 23.08% and 15.38% respectively for anterior cruciate ligament tear, medial meniscus, and lateral meniscus injury. 42.65% anterior cruciate ligament injuries were associated with concomitant injuries, whereas significant risk for early OA was 17.24% as compared to isolated ACL injuries of 57.35% with significant risk for early OA of 10.25%. Concomitant meniscal and ACL injuries had significant risk for early OA was 23.53%. Conclusion: Arthroscopic evaluation of articular Cartilage damage after Knee injuries is good predictor of early Osteoarthritis in young population.
Frequency, Presentation, Management and Outcome of Snake Bite in Children at DGKMC & Hospital, D.G Khan.
Authors: Asma Akbar  , Irum Jabeen  , Irfan Karim  , Zohaib Hassan  , Shakeel Ahmad  , Nusrat Buzdar
Published: May 2023

Objective: To evaluate the frequency, common presentation, anti-snake venom (ASV) related management and outcome of snake bite cases in admitted children at a tertiary care hospital. Study Design: Case-series study. Setting: Department of Pediatric, Dera Ghazi Khan Medical College (DGKMC) & Hospital. Period: 1st March 2021 to 31st August 2021. Material & Methods: During the study period, all children presenting with snake bite were included. All cases were observed for their presentation, classified according to signs and symptoms, and managed through ASV as needed. Results: During the study period, a total of 52 patients of snake bite admitted in paediatric medical ward of DGKMC & Hospital. There were 37 (71.2%) male and 15 (28.8%) female. Overall, mean age of the children was 6.1±3.1 years. Maximum number of snake bite cases were reported during May, June and July as 15 (28.8%), 13 (25.0%) and 8 (15.4%) respectively. In the presentation, 29 (55.8%) patients presented with local symptoms only while remaining 23 (44.2%) presented with local as well as systemic symptoms. In the management, 3 (5.8%) cases did not require any ASV vial, 35 (67.3%) needed initial doses only. Fourteen (26.9%) cases required initial as well as maintenance doses. In terms of outcome, 49 (94.2%) children were discharged successfully, 1 (1.9%) expired and 2 (3.8%) got left against medical advice (LAMA). Conclusion: Snake bite was a common pediatric medical emergency at our institute. Most children presented with hemotoxic symptoms and needed ASV for resolution of symptoms. Prognosis is good with timely and judicious management of snake bite.
Implementasi Algoritma Cheapest Insertion Heuristic dalam Menentukan Rute Pengiriman Barang
Authors: Fargiana Farid Risqullah
Published: May 2023

Abstract. The online trading system has become a common thing for today's society. Freight forwarding companies, whose job is to deliver goods from sellers to buyers, have an important role in online trading. One of the freight-forwarding companies is SiCepat Express Baleendah. The delivery route used by SiCepat Express Baleendah is not organized so it is often inefficient. This problem in Mathematics is known as the Traveling Salesman Problem and can be solved using the Cheapest Insertion Heuristic (CIH) Algorithm. Hence, it is necessary to know how to determine the route of delivery of goods using the CIH Algorithm, also, the comparison of results and efficiency between the routes obtained from the application of the CIH Algorithm and the routes used by SiCepat Express Baleendah. From the research, it was found that the total distance for shipping goods obtained using the CIH Algorithm with Python was 3,757 km, while the route from SiCepat Express Baleendah was 4.840 km. The application of the CIH Algorithm with Python is proven to provide a route with a total distance of 22.38% smaller than the total distance traveled by the route used by SiCepat Express Baleendah.

Abstrak. Sistem jual beli secara online sudah menjadi hal yang umum bagi kalangan masyarakat saat ini. Perusahaan pengirim barang, yang bertugas untuk mengirimkan barang dari penjual ke pembeli, memiliki peran penting dalam jual-beli online. Salah satu perusahaan pengiriman barang adalah SiCepat Express Baleendah. Rute pengiriman barang yang digunakan oleh SiCepat Express Baleendah tidak terorganisir sehingga seringkali tidak efisien. Permasalahan tersebut dalam Ilmu Matematika dikenal sebagai Travelling Salesman Problem dan dapat diselesaikan dengan Algoritma Cheapest Insertion Heuristic (CIH). Berdasarkan hal tersebut perlu diketahui cara menentukan rute pengiriman barang menggunakan Algoritma CIH serta perbandingan hasil dan efisiensi antara rute yang diperoleh dari penerapan Algoritma CIH dengan rute yang digunakan SiCepat Express Baleendah. Dari penelitian didapatkan total jarak tempuh pengiriman barang yang diperoleh menggunakan Algoritma CIH dengan Python adalah sebesar 3,757 km, sedangkan hasil yang digunakan oleh SiCepat Express Baleendah adalah sebesar 4,840 km. Penerapan Algoritma CIH dengan Python terbukti memberikan rute dengan total jarak tempuh 22,38% lebih kecil dibandingkan total jarak tempuh rute yang digunakan oleh SiCepat Express Baleendah.