bluuebunny/crossref_metadata_2025 huggingface dataset:
Coronavirus Inhibitory Activity of Tamarind Indica
Authors: Danao Kishor , Shivhare Ruchi , Nandurkar Deweshri , Rokde Vijayshri , Mahajan Ujwala
Published: May 2023

Background:

SARS-COVID-19 is an infectious disease, the causative agent Caroni virus.
WHO announced the pandemic on 3rd November 2020 to the whole world.

Objective:

Severe Acute Respiratory Syndrome COVID-19 is an infectious disease globally declared a
pandemic by WHO. There is a need to find the proper medication for recovery. The study uses the molecular
docking method to predict the anti-covid activity of plant phytoconstituents of Tamarind indica.

Methods:

Molecular docking techniques were accomplished to search the binding pattern of plant phytoconstituents
of T. indica against the crystal structure SARS-CoV-2 enzyme (PDB ID: 6LU7) with the help
of PyRx virtual screening software to study the amino acid interaction and inhibitory potential of phytoconstituents
of T. indica. In addition, we performed a pharmacokinetic and toxicological study of plant
phytoconstituents of T. indica using SwissADME and the pkCSM online server.

Results:

The phytoconstituents of Plant T. indica docking results proposed that apigenin (-7.8 kcal/mol),
epicatechin (-7.1 kcal/mol) and taxifolin (-7.5 kcal/mol) show the best binding energy as compared to
favipiravir (-5.2 kcal/mol). The phytoconstituents exposed promising interaction with amino acid residue,
leading to an inhibitory effect against the SARS-CoV-2 enzyme (PDB ID: 6LU7). Further, ADMET studies
showed that pharmacokinetics and toxicological parameters are within acceptable limits.

Conclusion:

In silico study revealed that the phytochemicals of T.indica show promising inhibitory results
against the SARS-CoV-2 enzyme (PDB ID: 6LU7). Moreover, the traditional benefits
of T.indica were clinical treatment and drug discovery.
Developments in Synthesis Strategies of Spiro-Barbiturate Compounds: A
Classified Study
Authors: Magoo Devanshi , Srivastava Anju , Gupta Shruti , Jain Reena , Mondal Ghorai Soma , Dawer Yashna , Sengupta Sumedha , Rani Soni
Published: May 2023

Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three
dimensionalities, and prominently hold a position of interest in the fields of synthetic and medicinal
chemistry, pharmacology, material sciences and physics. Spirobarbiturate compounds which incorporate
barbituric ring derivatives into spirocyclic structures have emerged as attractive synthetic targets
for drug discovery as they are known to exhibit far-ranging pharmacological applications. In this review,
we aim to bring to light the extensive, contemporary research applied to the synthesis of different
spirobarbiturates having varied ring sizes (3, 5, 6 and 7 membered) in a classified manner. It presents
the reported methods of synthesis along with their mechanistic pathways as well as the pharmacological
activities of some of these synthesized biologically significant motifs.
Efficacy of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
in the Diagnosis of Mediastinal and Hilar Lesions
Authors: Liu Ting , Zhang Wenli , Liu Chunmei , Wang Leqiang , Gao Haipeng , Jiang Xiaoxue
Published: May 2023

Background:

Mediastinal and hilar lesions may be benign or malignant. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is increasingly used for the diagnosis of these lesions as it is both minimally invasive and safe.

Objective:

To investigate the clinical efficacy of EBUS-TBNA in the diagnosis and differential diagnosis of mediastinal and hilar lesions.

Methods:

A retrospective observational study was undertaken to investigate patients diagnosed with mediastinal and hilar lymphadenopathy based on imaging at our hospital from 2020 to 2021. After evaluation, EBUS TBNA was used and data including the puncture site, postoperative pathology, and complications were recorded.

Results:

Data from 137 patients were included in the study, of which 135 underwent successful EBUS TBNA. A total of 149 lymph node punctures were
performed, of which 90 punctures identified malignant lesions. The most common malignancies were small-cell lung carcinoma, adenocarcinoma,
and squamous cell carcinoma. Forty-one benign lesions were identified, resulting from sarcoidosis, tuberculosis, and reactive lymphadenitis,
amongst others. Follow-up findings showed that 4 cases were malignant tumors, with 1 case of pulmonary tuberculosis and 1 case of sarcoidosis).
Four specimens where lymph node puncture was insufficient were subsequently confirmed by other means. The sensitivity of EBUS TBNA for
malignant lesions, tuberculosis and sarcoidosis in mediastinal and hilar lesions was 94.7%, 71.4%, and 93.3%, respectively. Similarly, the negative
predictive values (NPV) were 88.9%, 98.5%, and 99.2%, and the accuracy was 96.3%, 98.5%, and 99.3%.

Conclusion:

EBUS TBNA is an effective and feasible approach for the diagnosis of mediastinal and hilar lesions that is minimally invasive and safe.
Hounsfield Unit Variations-based Liver Lesions Detection and Classification
using Deep Learning
Authors: Phan Anh-Cang , Trieu Thanh-Ngoan , Phan Thuong-Cang
Published: May 2023

Background:

Deep learning-based diagnosis systems are useful to identify abnormalities in medical images with the greatly increased workload of doctors.
Specifically, the rate of new cases and deaths from malignancies is rising for liver diseases. Early detection of liver lesions plays an extremely
important role in effective treatment and gives a higher chance of survival for patients. Therefore, automatic detection and classification of
common liver lesions are essential for doctors. In fact, radiologists mainly rely on Hounsfield Units to locate liver lesions but previous studies
often pay little attention to this factor.

Methods:

In this paper, we propose an improved method for the automatic classification of common liver lesions based on deep learning techniques and the
variation of Hounsfield Unit densities on CT images with and without contrast. Hounsfield Unit is used to locate liver lesions accurately and
support data labeling for classification. We construct a multi-phase classification model developed on the deep neural networks of Faster R-CNN,
R-FCN, SSD, and Mask R-CNN with the transfer learning approach.

Results:

The experiments are conducted on six scenarios with multi-phase CT images of common liver lesions. Experimental results show that the proposed
method improves the detection and classification of liver lesions compared with recent methods because its accuracy achieves up to 97.4%.

Conclusion:

The proposed models are very useful to assist doctors in the automatic segmentation and classification of liver lesions to solve the problem of
depending on the clinician’s experience in the diagnosis and treatment of liver lesions.
Metformin: A Promising Radiosensitizer in Neoadjuvant Rectal Cancer
Treatment
Authors: Georgopoulos Nikolaos S. , Tolia Maria , Mauri Davide , Kamposioras Konstantinos , Charalampakis Nikolaos , Tsoukalas Nikolaos , Gkantaifi Areti
Published: May 2023

Background:

Neoadjuvant chemoradiotherapy (nCRT) decreases the risk of local
recurrence after surgery in patients with locally advanced rectal cancer (LARC) and metformin is
constantly gaining scientific interest due to its potentially radiosensitizing effect.

Objective:

This review article aims to better clarify the role of metformin as a radiosensitizer in
patients with LARC undergoing neoadjuvant concurrent chemoradiotherapy.

Methods:

We used the PubMed database to retrieve journal articles and the inclusion criteria were
all human studies that illustrated the effective role of metformin in the neoadjuvant setting of
locally advanced rectal cancer.

Results:

Our search resulted in 17 citations, of which 10 eventually fulfilled the inclusion criteria
of our study. Promising results (improved tumor and nodal regression as well as higher pathologic
complete response rate) have been occasionally documented with metformin use in some of the
included studies. However, regarding survival and all-cause mortality, no significant difference has
been found.

Conclusion:

Metformin might constitute a highly promising radiosensitizer in neoadjuvant LARC
treatment attracting much scientific interest. Due to the lack of studies with high evidence, further
advanced research is required to enhance the existing knowledge about its potential value in this
field.
A Secure Network with Minimization of Energy for E-healthcare Application
in IoMT
Authors: Aluvalu Rajanikanth , V. Uma Maheswari , A. Mohan , Balagoni Yadaiah
Published: May 2023

Aims:

Protect patient healthcare records.

Background:

The adaptability of the digital healthcare system is a major factor in its recent rise in
popularity. Utilizing the digital healthcare system has resulted in an ever-increasing number of
healthcare apps. The Internet of Medical Things-(IoMT) is a newly emerging digital healthcare system
using various biomedical sensors and the cutting-edge capabilities of wireless systems and
cloud computing. Since IoMT can exchange data between various connecting nodes thanks to the
combination of other technologies, security and energy consumption provide the greatest challenge
to the IoMT infrastructure.

Objective:

Reduce the cost of communication in order to strengthen defenses against unauthorized
access and increase energy efficiency.

Method:

This study provides a protocol for protecting patients; medical records called the requesttype-
based energy-aware framework (Re-EAF) based on patent. The primary goal is to reduce the
cost of communication in order to strengthen defences against unauthorized access and increase energy
efficiency. An identifying unit called a request-type energy aware framework has been proposed.
The proposed method avoids treating all requests the same by instead characterizing them
based on the identified criteria and characteristics. Using Constrained Application Protocol (CoAP),
remote patient monitoring can increase the safety of gathered data.

Results:

Using Constrained Application Protocol (CoAP), remote patient monitoring can increase
the safety of gathered data. Using a software-defined networking (SDN) framework, our research
ensures that data and requests are sent and received as effectively and efficiently as possible while
conserving energy.

Conclusion:

In this research, the transmitted healthcare data is encrypted via cipher Block-chaining.
The experimental study demonstrates that the suggested Re-EAF consumes less energy while producing
a higher throughput than conventional methods.
Potential Disorders Caused by Traditional Herbal Medicines based on
Forensic Case Studies
Authors: Astaraki Peyman , Ahadi Maryam
Published: May 2023

Herbal medicines have long been used in therapeutic medicine owing to their minimal side
effects. However, contamination, inadequate purification, and adulteration can lead to adverse outcomes
upon intake. Several forensic case studies have reported that these compounds can be overdosed, leading
to serious effects and death. Furthermore, their interactions with pharmacological agents are poorly studied.
In forensic settings, mass spectrometry along with liquid chromatography is the most practiced method
to detect and quantity these agents.
Nanomaterials as Theragnostic Tools of Detection and Fighting off the Virus
Authors: Sharma Rama
Published: May 2023

The primary cause of death worldwide is an infectious disease, and viruses in particular, have a
major worldwide impact on health and economic growth. A critical public health problem is the quick
emergence of medication resistance to currently accessible treatments as well as negative side effects
from repeated use. Therefore, the creation of novel treatment plans is necessary. In contrast to
conventional chemical-based antiviral drugs, the use of nanoparticles offers an alluring potential for the
development of innovative antiviral therapies with minimal risk of acquiring drug resistance.
Nanomaterials make it simple to change the properties of accessible resources. Nanomaterials can be
readily applied to modify the available detection platforms to improve their sensitivity. Due to their high
surface-to-volume ratio, NPs readily bind to either the viral membrane proteins or the viral reproduction
system (DNA/RNA), thus hindering the virus' ability to infect cells. Viral proliferation has been inhibited
by the use of metal nanoparticles (NPs) such as gold, silver, and copper. Copper has repeatedly been examined
for its strong anti-microbial qualities due to its lower cost than silver and gold. The virus's inactivation
on copper surfaces after 4 hours raises the possibility that copper could be used to destroy the infection.
Also, it was discovered that 50% of virus-like particles (VLPs) could be rendered inactive by
copper composite nanoparticles in just 10 minutes. The medical community could benefit greatly from
sophisticated smartphone and/or LFA-based detection techniques that can be used right at the patient's
bedside. This review discusses methods based on nanotechnology for diagnosing and treating viral
diseases, especially HIV and influenza.
Medicinal Properties of Crotalaria burhia: A Review
Authors: Wal Pranay , Shukla Vibha , Uzzaman Khan Mohd Masih , Gaur Khushboo , Wal Ankita , Kumar Jain Nem
Published: May 2023

Background:

Natural products have a crucial role in the discovery and development of
drug molecules. The secondary metabolites derived from the plant have potential therapeutic value
and reveal many pharmacological effects. Crotalaria burhia Buchham, a Leguminaceae herb, is
mostly present in arid parts of India, Pakistan, China, and Afghanistan. Shinio, Bhip, Bhata, Ghugato, and Ban Sutra are just a few of the names it goes by. It is used to cure gout, eczema, hydrophobia, and inflammation. Plant root porridge is used for typhoid, wounds and cuts, rheumatism,
flatulence, earaches, nasal bleeding, and stone problems. The powder form of the plant is used for
digestive disorders. The plant has potent pharmacological activity and is also carcinogenic and anticarcinogenic in nature. Various phytoconstituents are present, like tannins, amino acids, alkaloids,
steroids, triterpenoids, mucilage, flavonoids, gum, polyphenols, anthraquinones, carbohydrates, glycosides, and saponins. Croburhine is a novel pyrrolizidine alkaloid obtained from it. This review focuses on the existing knowledge of the phytochemistry and pharmacological action of C. burhia,
which will provide broad information for a proper assessment of the plant as a medicinal agent.

Methods:

The experimental analysis and data reported on the species of Crotalaria were reviewed
from 2005 to 2022. Various databases were used as article sources, like Medline and Pubmed, and a
literature review was done using the keywords Crotalaria burhia, habitat, species, pharmacological
action, and traditional uses.

Result:

On the basis of our perception, we have stated that the species Crotalaria burhia is a golden
herb that possesses potent pharmacological activities. It is widely used as a conventional drug for
the cure of various diseases, but its active constituents need to be evaluated more for future drug
development and pharmacological action.

Conclusion:

There were a total of 21 research articles about the phytochemical screening of herbs,
which showed the presence of different active constituents like alkaloids, tannins, flavonoids, steroids, glycosides, mucilage, gum, polyphenols, carbohydrates, terpenoids, etc., which are responsible
for different pharmacological activities like antioxidant, antimicrobial, anti-inflammatory, antinociceptive, antihypertensive, antitumor, and analgesic activity.
The Effect of Date Palm (Phoenix dactylifera L.) Pollen on the Serum
Levels of Testosterone, Luteinizing, and Follicle Stimulating Hormones
in Men
Authors: Karimi Mehrdad , Asbagh Firoozeh Akbari , Safavi Majid , Yekaninejad Mir Saeed , Rahimi Roja , Pourmand Gholamreza , Mirzaei Mohammadreza , Farshbaf-Khalili Azizeh
Published: May 2023

Background:

Date Palm Pollen (DPP) has traditionally been used to increase sexual
ability and fertility. In several animal studies, the effects of this herbal medicine on testosterone,
luteinizing hormone (LH), and follicle-stimulating hormone (FSH) have been shown.

Objectives:

This study was conducted to evaluate the effects of this drug on the serum levels of
testosterone, LH, and FSH in men.

Methods:

In this semi-experimental study, a daily dose of 6 g dry powder of DPP in two separate
doses (3 g every 12 hours) was administered orally to 30 eligible men for three months. The
changes in mean serum levels of hormones were statistically evaluated after the intervention
compared to the baseline. The serum concentration of the hormones was assayed through the
enzyme-linked immunosorbent assay method. Data were analyzed using paired t-tests.

Results:

After recruitment, among 30 participants, 24 men received the intervention and finally
were analyzed. The mean (SD) age and body mass index of participants were 32.85 (0.43) years and
26.5 (0.5) kg/m2
. DPP significantly increased the serum levels of testosterone (from 5.31±0.40ng/ml
to 6.88±0.71 ng/ml; p=0.019) but did not affect the serum levels of FSH (from 4.31±0.50 IU/L to
4.70±0.61 IU/L; p=0.511). It also significantly decreased the serum levels of LH (from 5.65±0.81
IU/L to 4.52±0.90 IU/L; p= 0.033). There were no reported side effects.

Conclusion:

The results indicated an increasing effect of DPP on serum testosterone and decreasing
effect on serum LH. However, DPP had no significant effect on FSH serum levels.
An APT Attack Detection Method of a New-type Power System Based on
STSA-transformer
Authors: Yuan Jiexuan , Li Yuancheng
Published: May 2023

Background:

Complex structures such as a high proportion of power electronic equipment
has brought new challenges to the safe and stable operation of new-type power system, increasing
the possibility of the system being attacked, especially the more complex Advanced Persistent
Threat (APT). This kind of attack has a long duration and strong concealment.

Objective:

Traditional detection methods target a relatively single attack mode, and the time span of
APT processed is relatively short. None of them can effectively capture the long-term correlation in the
attack, and the detection rate is low. These methods can’t meet the safety requirements of the new-type
power system. In order to solve this problem, this paper proposes an improved transformer model
called STSA-transformer algorithm, and applies it to the detection of APT in new-type power systems.

Methods:

In the STSA-transformer model, the network traffic collected from the power system is
first converted into a sequence of feature vectors, and the location information and local feature of
the sequence, is extracted by combining position encoding with convolutional embedding operations,
and then global characteristics of attack sequences is captured using the multi-head selfattention
mechanism of the transformer encoder, the higher-frequency features of the attention are
extracted through the self-learning threshold operation, combined with the PowerNorm algorithm to
standardize the samples, and finally classify the network traffic of the APT.

Results:

After multiple rounds of training on the model, the expected effect can be achieved and
applied to the APT detection of a new-type power system.

Conclusion:

The experimental results show that the proposed STSA-transformer algorithm has better
detection accuracy and lower detection false-alarm rate than traditional deep learning algorithms
and machine learning algorithms.
Bigels; A Charismatic Drug Delivery Formulation
Authors: Bhattacharya Sankha , Singhai Manu
Published: May 2023

Bigels are a novel concept in contrast to previous gel formulations. To look like one
gel, bigels are made by merging two gel phases at high shear rates. Colloidal gels can be the
same (as in water-in-water bigels, which are phase-separated systems), the same but different,
or a combination of a hydrogel and an oleogel. These colloidal gels are utilized to construct
bigels (oleogel-in-hydrogel bigels or hydrogel-in-oleogel bigels). Bigels have appealing qualities
like hydrophilic and hydrophobic properties, improved spreadability, improved drug penetration,
higher stratum corneum hydration, and the capacity to control the drug release rate. Bigels'
mechanical, structural, thermal, physical, rheological, and electrical properties are crucial to their
practical and successful use in a variety of commercial applications. In this compilation, we have
talked about the convenience and interest of bigels as a formulation for novel applications in the
pharmaceutical, cosmetic, and food industries. The use of several notable bigels is also discussed
in the paper. The Bigels are widely utilized in the food and pharmaceutical industries as well.
The Bigels are now being researched as possible drug delivery matrices.
Misdiagnosis of Tuberculosis
Authors: Goswami Gauri , Mehta Yatin , Singh Lalit , Garg Ayush
Published: May 2023

Introduction: High incidence of tubercular cases in developingcountries, similar clinical presentation of tuberculosis andmalignancy, lack of adequate infrastructure, and lack ofproper follow up are the most common factors associated withmisdiagnosis.Case Summary: A 72 years old male CAME with complainsof cough with expectoration for 2 month, intermittent feverassociated with chills and rigors for 1 month, loss of appetiteand weight, intermittent pain in right side of the chest for1 month. Patient was a known smoker and alcoholic. Onauscultation bilateral air entry was decreased with occasionalrhonchi. Patient’s chest x-ray was suggestive of consolidationin right upper zone of chest. His sputum was negative forAFB from outside, patient started on ATT, 2 months prior todate of admission from private clinic on empirical basis thatwas continued till the date of admission. Patient showed noimprovement, even after 2 months of ATT. His chest X-Ray wassuggestive of right upper zone consolidation, patient had noprior radiography for comparison. He was continued on ATTas he had already taken treatment for 2 months from outside.Patient was tested negative for sputum AFB 1 and 2, CBNAATand culture.Patient presented to emergency after a gap of two monthsin state of drowsiness with complains of breathlessness andsevere right side chest pain. He was intubated in emergencyand managed on ventilator support. Patient recovered and aCECT thorax was done suggestive of likely possibility of rightlung upper lobe neoplasm with metastatic lymphadenopathywith possibility of multiple liver and bilateral adrenal metastasisand changes of chronic airways disease with fibro bullouschanges in bilateral upper lobe apical segments. The FNACwas positive for malignant cells with features suggestive of nonsmallcell carcinoma – (possibly adenocarcinoma). Patient wasfurther managed in the department of Radiation Oncology bychemotherapy. We discuss the radiographical progression andsubsequent investigations required to make a proper diagnosis.Conclusion: It is imperative to form a conclusive diagnosisusing available diagnostic modalities in smear negativetubercular cases to avoid delay in management of otherpossible life-threatening diseases like lung carcinomas.
Physicochemical properties, total plate count, and sensory acceptability of gummy guyabano (Annona muricata) candy enriched with kappacarrageenan
Authors:   College of Fisheries and Allied Sciences, Northern Iloilo State University, Concepcion, Iloilo, Philippines, Minguito Joram T.
Published: May 2023

Gummy candy is usually made of gelatin- sourced from animals. This study incorporated (κ) kappa-carrageenan-A polysaccharide extract from seaweeds into the gummy guyabano (Annona muricata Linnaeus) candy’s formulation. κ-carrageenan was incorporated into the gummy guyabano candy at 0%, 1%, 3%, and 5% concentration for CO, T1, T2, and T3, respectively. The effect of incorporating kappa-carrageenan into gummy guyabano candy in terms of physicochemical properties, total plate count, and sensory acceptability was investigated. Results showed that an increase in the addition of κ-car resulted in an increment in most of the physicochemical properties, e.g., carbohydrate content (42.66 ± .98 - 44.93 ± .74) and crude fiber with values 00.19 ± .07 to 00.40 ± .11. Further, a decreasing value for crude protein (16.07 ± .74 - 15.48 ± .24), and fat content (00.32 ± .14 - 00.02 ± .03) was noted. However, no significant difference was found in crude protein. Gel strength was affected by the increasing addition of κ-car. Values recorded were 1029.67 ± 62.74, 735.00 ± 31.19, 1369.33 ± 54.00, and 1278.00 ± 93.54 for CO, T1, T2, and T3, respectively. Total plate count rose as the percentage of κ-car increased, from <250 EAPC/g to 4.66 x 104 cfu/g, but results were within the range of the recommended TPC values by FDA for confectionery products. Moreover, results of sensory acceptability revealed that all formulations were generally accepted, with "Like Moderately" as the lowest rating and the highest rating as "Like Very Much." Thus, kappa-carrageenan has enriched the physicochemical properties of gummy guyabano candy.
Dinamika Regulasi Sertifikasi Halal di Indonesia
Authors: Sup Devid Frastiawan Amir , Fahmi Annas Syams Rizal , Hilal Faridl Noor , Firdaus Muhammad Irkham
Published: May 2023

The need for halal products in Indonesia is increasing rapidly, considering that Indonesia is a country that has a large Muslim population. To oversee that each product is halal guaranteed, one of the efforts made by the government is through regulation. In Indonesia, this regulation apparently experienced several changes/renewals. This study aims to describe how the dynamics of halal regulation in Indonesia from time to time. The method used is qualitative-descriptive-literature. The result obtained, that there are changes and renewal of regulations relating to the guarantee of halal products in Indonesia are the right steps (in his time) taken by the government to maintain the existence of halal products circulating in Indonesia to be in accordance with the concept of halal in Islam.
Implementasi Kepemimpinan Otentik dan Person-Organisation Fit serta Hubungannya dengan Kontrak Psikologis dan Komitmen Organisasional Islami
Authors: Suhartini Tien
Published: May 2023

Penelitian mengenai kepemimpinan telah dilakukan berpuluh tahun yang lalu di berbagai negara. Topik ini memang selalu menarik karena organisasi selalu mengalami perubahan, baik dipengaruhi oleh faktor internal maupun eksternal, sehingga para  peneliti berusaha terus mencari kelebihan dan kelemahan gaya kepemimpinan agar bisa menemukan tipe kepemimpinan yang paling dibutuhkan dalam sebuah organisasi, yang membuat organisasi tersebut bisa sustain. Sementara ini, Kepemimpinan Otentik (Authentic Leadership) dianggap paling sesuai untuk berbagai organisasi. Bagi seorang pekerja, kesesuaian yang dibutuhkan tidak  hanya dengan pemimpin, tapi juga dengan lingkungan organisasi agar tercipta perasaan nyaman selama bergabung dengan organisasi tersebut. Perasaan nyaman dan terikat dengan organisasi ini bisa memperkuat kontrak psikologis pekerja, yang pada gilirannya akan memunculkan komitmen. Tulisan ini merupakan conceptual paper yang tidak hanya meringkas penelitian terbaru, tetapi juga menyediakan integrasi literatur, menawarkan kerangka kerja terintegrasi, memberikan nilai tambah, dan menyoroti arah untuk penyelidikan di masa depan. Tujuan utama dari penelitian ini adalah untuk mengembangkan model hubungan antara kepemimpinan otentik dan kesesuaian pekerja-organisasi dengan kontrak psikologis Islami dan komitmen organisasional Islami
Work Ethic And Strategic Development of Batik Pekalongan Indonesia on Islamic Business Perspective
Authors: Masrur Muhamad , Arwani Agus
Published: May 2023

This paper aims to find out how the work ethics of Pekalongan batik entrepreneurs and the business development strategies of Pekalongan batik entrepreneurs from perspective of Islamic business ethics. This study uses a qualitative approach by observations, interviews, and documentation to Muslim entrepreneurs. The results study note that batik entrepreneurs in Pekalongan conduct their business with a high work ethic spirit, nature maintains and develops business, they do business development strategies mostly by Islamic business ethics, both from marketing strategies such as products, prices, distribution of promotions, and sales systems that adapted times, treating employees, still less additional capital that is related to conventional banking, and still a lack of awareness not to dispose of batik waste in rivers. The findings of the study that the businessman batik Muslims in Pekalongan have the ethic of work are high and pass strategy development effort batik using principle business of Islam.  
Analisis Kinerja Perbankan Syariah di Indonesia : Studi Masa Pandemi Covid-19
Authors: Azhari Allselia Riski , Wahyudi Rofiul
Published: May 2023

The Covid-19 pandemic has spread to various countries, including Indonesia. As a result, almost all sectors experienced contractions, including Islamic banking. However, Islamic banking is considered quite capable of surviving the storm of impact based on the previous crises' empirical facts. The purpose of this study is to analyze how the performance of Islamic banking during the Covid-19 pandemic. This research method uses a descriptive approach with a sample of 14 Islamic Commercial Banks in Indonesia. Secondary data in the form of financial report panel data is the source of data for the January - July 2020 period, obtained from the monthly reports of each Islamic bank. The results showed that Islamic banking performance based on debt financing fluctuated, while the performance based on equity financing experienced growth. The performance of third party funds has fluctuated.
Apakah Literasi Mempengaruhi Penerimaan Zakat?
Authors: Canggih Clarashinta , Indrarini Rachma
Published: May 2023

Zakat is not only relates to ilahiyah worship but also relates to muamalah which has social and economic value. Zakat can be used as a tool to increase welfare and eradicate poverty. Since, Indonesia has large Muslim population, it supposes to has large amount of Zakat. However, the actual recorded zakat collection is still very far from the potency. People zakat literacy about zakat obligations is also low. This paper aims to see the impact pf zakat literacy to zakat collection by OPZ. This research was an associative quantitative study using PLS-SEM bootstrap with WarpPLS5. The object of this research was 9 OPZs (8 LAZNAS and 1 BAZ) which have representative offices in Surabaya. Respondents of this study were muzakki who represented OPZ. The results of this study indicated that zakat literacy has a significant effect on the realization of zakat collection, however the intention to pay zakat does not mediate the relationship between literacy and the realization of zakat collection. This research can be used to identify steps to increase zakat collection.
Analysis Concept of a Mosque-Based Community Economic Empowerment Strategy at the Islamic Center Dato Tiro Bulukumba
Authors: Rusanti Ega , Sofyan A Syathir , Syarifuddin Syarifuddin
Published: May 2023

The purpose of this research is to find out and analyze the concept of mosque- based economic empowerment at Dato Tiro Islamic Center in Bulukumba Regency which has been and should be carried out. The research conducted is a qualitative study with field research (field studies) in the deepening of the reference as a source of primary and secondary data, while in the collection of data used methods of observation, interviews and documentation. The results of the study show that the concept of empowerment that is being applied today such as the use of a multipurpose floor as a market area every Friday is effective enough for the community and the prosperity of the mosque. It's just that there are many other potential possessed by the mosque that can be developed in an effort to empower the Ummah, establishing BMT as a form of financial assistance to the community in building a business. So that the mosque is able to carry out its function not only as a means of worship but also has a role in building the economy of the Ummah.
Apakah Ekuitas Merek dan Kesadaran Halal Memediasi Pengaruh Religiusitas dan Akulturasi terhadap Keputusan Pembelian?
Authors: Sari Dwi Ratna , Rohimat Asep Maulana , Ahmad Zulfikar Ali
Published: May 2023

When the Korean Wave became a new trend in Indonesia, many Indonesian Muslims were influenced by the Korean culinary culture. Many people do not pay attention to the halal aspects of food, especially Korean food where the majority of the population is non-Muslim. From this the researchers conducted research on the effect of religiosity and acculturation on halal decisions with brand equity and halal awareness as mediating variables. This study uses a convenience sampling method with Korean food consumer object samples taken as many as 97 respondents randomly. Data analysis techniques used are multiple linear regression tests and multiple tests. The results of the study show that religiosity has a significant effect on brand equity, acculturation has a significant effect on brand equity, religiosity has a significant effect on halal awareness, but acculturation has a not significant effect on halal awareness, religiosity and acculturation has a significant effect on purchasing decisions, brand equity has an effect on significant on purchasing decisions and halal awareness has a significant effect on purchasing decisions. Brand equity mediates the effect of religiosity and acculturation on purchasing decisions. Meanwhile, halal awareness mediates the influence of religiosity on purchasing decisions.
Analisis Pengaruh Pendistribusian Dana Zakat Terhadap Mustahik Ditinjau Dengan Menggunakan Metode CIBEST
Authors: Salam Abdul , Nisa Rif'atun
Published: May 2023

This study aims to analyze the distribution of productive zakat funds to mustahik materially and spiritually. The type of research used by researchers here uses a qualitative-quantitative approach where the population is 40 households according to the BAZNAS Yogyakarta City data in 2018, the analysis tools used are data reduction, data presentation and drawing conclusions. The results of this study indicate that the increase in the welfare level of mustahik is 53%, indicating that there is a decrease in the percentage of 37% of the community, where initially 34 out of 40 mustahik are in quadrant II (material poverty) to 20 out of 40 mustahik alone are still in material the poverty quadrant. Meanwhile, the welfare quadrant itself has increased where previously there were only 5 out of 40 households that were included in this quadrant to 19 out of 40 households, where as many as 22 mustahik who were included in quadrant II (material poverty) moved to quadrant I (prosperous)
Analisis Dana Zakat, Penerimaan Non Halal, dan Corporate Social Responsibility (CSR) Pada Bank Syariah Di Indonesia
Authors: Syafina Laylan , Nurwani Nurwani
Published: May 2023

Zakat funds are funds obtained from Muslim assets that have exceeded the haul and nisab that must be fulfilled. Zakat funds have the opportunity to improve the people's economy. Zakat funds are also related to non-halal receipts which are reflected in reports on the sources and uses of benevolent funds. This report is usually related to social activities, which means it is related to the CSR of the Islamic bank. The study was conducted on all Islamic commercial banks in Indonesia starting from 2016 to 2020. Using eviews 7 to analyze the data. The results of this study show that zakat funds and non-halal revenues partially and significantly influence Corporate Social Responsibility (CSR) and simultaneously zakat funds and non-halal revenues also have a significant and significant effect on Corporate Social Responsibility (CSR).
Determinants of Generation Z in Paying Zakat, Infaq, and Alms (ZIS) Online in the City of Surabaya
Authors: Rachmawati Laela Nur , Canggih Clarashinta
Published: May 2023

(ZIS) in Indonesia has enormous potential in obtaining fundraising, where the Muslim population dominates. However, the facts that occur in the field are that the maximum amount of ZIS fund collection has not been realized. The existence of online ZIS today is a form of innovation for zakat institutions in the era of technological development to be able to help encourage an increase in ZIS collection. This study aims to analyze the factors that influence Gen Z's interest in paying ZIS online. This study uses associative quantitative methods with Sem-PLS analysis and the Smart PLS analysis tool. Sampling used a purposive sampling technique with sample criteria namely Gen Z (15-25) years old Muslims in the city of Surabaya. The results of the study show that the accountability variable influences Gen Z's interest in paying ZIS online. If accountability has increased, the interest of Gen Z in the city of Surabaya in paying ZIS online has increased. Meanwhile, the variables of usability, ease of use, risk, and transparency do not affect Gen Z's interest in making ZIS payments online. The findings from this study are that it can be used to improve the online ZIS system so that fundraising can increase.
Development of a Tourism Village Efforts to Empower the Community's Economy from an Islamic Economic Perspective: A Case Study of West Lombok's Kebon Ayu
Authors: Kurniati Fitri Zahratul Aini , Mansyur Zainudin , Mulhimmah Baiq Ratna
Published: May 2023

The tourism sector in the world economy has a role to play as a contributor to employment and economic growth. In the current era of regional autonomy, villages are given the authority to regulate wider community interests, aiming to accelerate the realization of community welfare through service, empowerment, and the role of village communities, as well as increasing regional competitiveness by taking into account the principles of equity and justice. The development of tourism villages is a new idea related to the utilization of village potential, which is expected to be packaged into tourism products that can preserve local wisdom, where community empowerment becomes a public concern and is considered one of the appropriate approaches in overcoming the problem of poverty. So that empowerment can form an economically self-sufficient society. This study aims to find out how to implement the economic empowerment of the people of Kebon Ayu Village through the Tourism Village Program and what obstacles are encountered in this implementation. The research method used is qualitative research with data collection carried out using observation, documentation, and interviews. Data analysis techniques are carried out by reducing, presenting, and drawing conclusions. The results of the study show that community economic empowerment through the Tourism Village program has a positive impact on increasing people's income and creating employment opportunities through training and providing business facilities. The main obstacles faced were the lack of business capital, lack of public awareness, and inadequate promotion and marketing media.
Analysis of Ecobrick Economic Potential in Improving Community Economic Welfare: Case Study of Bukit Lawang Plantation, Kab. Langkat
Authors: Nurhalisa Siti , Nawawi Zuhrinal M
Published: May 2023

Economic potential shows the ability of economic resources produced by an area that needs to be developed to provide added value for economic development. The economic potential of the ecobrick community in the Bukit Lawang plantation village can be seen from the many economic resources generated from the utilization of ecobrick such as the construction of a recycling village and the manufacture of modular furniture crafts. With the use of ecobricks, they become goods that have economic value so that they can improve the economic welfare of the community. This study used a descriptive qualitative research method, with the data sources used in the form of primary and secondary data. Data collection techniques were used in the form of interviews, observation, and direct surveys. The research results obtained that the Bukit Lawang Plantation Village is one of the areas that utilize waste to become ecobrick as a manifestation of a creative business that can become a selling point of quality goods so that the use of ecobrick can improve the economic welfare of the community by fulfilling the needs for clothing, food, and shelter. that is needed by society. The use of this ecobrick is the result of an agreement from the community to utilize plastic waste to become a quality selling point.
Assessment of Frailty by the French Version of the Vulnerable Elders Survey-13 on Digital Tablet: Validation Study
Authors: Zolnowski-Kolp Victoria , Um Din Nathavy , Havreng-Théry Charlotte , Pariel Sylvie , Veyron Jacques-Henri , Lafuente-Lafuente Carmelo , Belmin Joel
Published: May 2023

Background

Frailty assessment is a major issue in geriatric medicine. The Vulnerable Elders Survey-13 (VES-13) is a simple and practical tool that identifies frailty through a 13-item questionnaire completed by older adults or their family caregivers by self-administration (pencil and paper) or by telephone interview. The VES-13 provides a 10-point score that is also a recognized mortality predictor.

Objective

This study aims to design an electronic version of the Echelle de Vulnérabilité des Ainés-13, the French version of the VES-13 (eEVA-13) for use on a digital tablet and validate it.

Methods

The scale was implemented as a web App in 3 different screens and used on an Android tablet (14.0× 25.6 cm). Participants were patients attending the outpatient clinic of a French geriatric hospital or hospitalized in a rehabilitation ward and family caregivers of geriatric patients. They completed the scale twice, once by a reference method (self-administered questionnaire or telephone interview) and once by eEVA-13 using the digital tablet. Agreement for diagnosis of frailty was assessed with the κ coefficient, and scores were compared by Bland and Altman plots and interclass correlation coefficients. User experience was assessed by a self-administered questionnaire.

Results

In total, 86 participants, including 40 patients and 46 family caregivers, participated in the study. All family caregivers had previously used digital devices, while 13 (32.5%) and 10 (25%) patients had no or infrequent use of them previously. We observed no failure to complete the eEVA-13, and 70% of patients (28/40) and no family caregivers needed support to complete the eEVA-13. The agreement between the eEVA-13 and the reference method for the diagnosis of frailty was excellent (κ=0.92) with agreement in 83 cases and disagreement in 3 cases. The mean difference between the scores provided by the 2 scales was 0.081 (95% CI–1.263 to 1.426). Bland and Altman plots showed a high level of agreement between the eEVA-13 and the reference methods and interclass correlation coefficient value was 0.997 (95% CI 0.994-0.998) for the paper and tablet group and 0.977 (95% CI 0.957-0.988) for the phone and tablet groups. The tablet assessment was found to be easy to use by 77.5% (31/40) of patients and by 96% (44/46) of caregivers. Finally, 85% (39/46) of family caregivers and 50% (20/40) of patients preferred the eEVA-13 to the original version.

Conclusions

The eEVA-13 is an appropriate digital tool for diagnosing frailty and can be used by older adults and their family caregivers. The scores obtained with eEVA-13 are highly correlated with those obtained with the original version. The use of health questionnaires on digital tablets is feasible in frail and very old patients, although some patients may need help to use them.
The Synergistic Effect of Nurse Proactive Phone Calls With an mHealth App Program on Sustaining App Usage: 3-Arm Randomized Controlled Trial
Authors: Wong Arkers Kwan Ching , Bayuo Jonathan , Wong Frances Kam Yuet , Chow Karen Kit Sum , Wong Siu Man , Lau Avis Cheuk Ki
Published: May 2023

Background

Although mobile health application (mHealth app) programs have effectively promoted disease self-management behaviors in the last decade, usage rates have tended to fall over time.

Objective

We used a case management approach led by a nurse and supported by a health-social partnership team with the aim of sustaining app usage among community-dwelling older adults and evaluated the outcome differences (i.e, self-efficacy, levels of depression, and total health service usages) between those who continued to use the app.

Methods

This was a 3-arm randomized controlled trial. A total of 221 older adults with hypertension, diabetes, or chronic pain were randomized into 3 groups: mHealth (n=71), mHealth with interactivity (mHealth+I; n=74), and the control (n=76). The mHealth application was given to the mHealth and mHealth+I groups. The mHealth+I group also received 8 proactive calls in 3 months from a nurse to encourage use of the app. The control group received no interventions. Data were collected at preintervention (T1), postintervention (T2), and at 3 months’ postintervention (T3) to ascertain the sustained effect.

Results

A total of 37.8% of mHealth+I and 18.3% of mHealth group participants continued using the mHealth app at least twice per week until the end of the sixth month. The difference in app usage across the 2 groups between T2 and T3 was significant (χ21=6.81, P=.009). Improvements in self-efficacy (β=4.30, 95% CI 0.25-8.35, P=.04) and depression levels (β=–1.98, 95% CI –3.78 to –0.19, P=.03) from T1 to T3 were observed in the mHealth group participants who continued using the app. Although self-efficacy and depression scores improved from T1 to T2 in the mHealth+I group, the mean values decreased at T3. Health service usage decreased for all groups from T1 to T2 (β=–1.38, 95% CI –1.98 to –0.78, P<.001), with a marginal increase at T3.

Conclusions

The relatively low rates of mHealth app usage at follow-up are comparable to those reported in the literature. More work is needed to merge the technology-driven and in-person aspects of mHealth.

Trial Registration

ClinicalTrials.gov NCT03878212; https://clinicaltrials.gov/ct2/show/NCT03878212

International Registered Report Identifier (IRRID)

RR2-10.1159/000509129
Nomenclature and diagnosis of seronegative celiac disease and chronic non-celiac enteropathies in adults
Authors: Gubska O.Yu. , Denesyuk O.R.
Published: May 2023

Small bowel villous atrophy is one of the main histopathological manifestations of chronic enteropathy. In most cases, this condition is caused by celiac disease. Celiac disease is an autoimmune disease that occurs in genetically predisposed individuals and is characterized by damage to the mucous membrane of the small intestine (T-cell-mediated enteropathy) due to the influence of gluten and is treated with the help of a lifelong gluten-free diet. Diagnosis of classic celiac disease does not cause difficulties. Diagnostic algorithms have been developed for years. Diagnostic problems arise when small bowel villous atrophy occurs in patients who have gastrointestinal symptoms but are negative for celiac disease-specific antibodies. Differential diagnosis of small bowel villous atrophy without serological markers for celiac disease in adults includes seronegative celiac disease and chronic non-celiac enteropathies. There has long been diagnostic and clinical uncertainty about these conditions. This uncertainty has led to misdiagnoses and increased the number of people following a gluten-free diet unnecessarily. Between September 2019 and July 2021, an international working group of 13 gastroenterologists from six countries worked to create a consensus on the nomenclature and diagnosis of seronegative celiac disease and non-celiac enteropathies in adults.