bluuebunny/crossref_metadata_2025 huggingface dataset:
Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro
Authors: Heuschkel Marina A. , Babler Anne , Heyn Jonas , van der Vorst Emiel P. C. , Steenman Marja , Gesper Maren , Kappel Ben A. , Magne David , Gouëffic Yann , Kramann Rafael , Jahnen-Dechent Willi , Marx Nikolaus , Quillard Thibaut , Goettsch Claudia
Published: September 2022

Introduction

Vascular calcification (VC) is a major risk factor for cardiovascular morbidity and mortality. Depending on the location of mineral deposition within the arterial wall, VC is classified as intimal and medial calcification. Using in vitro mineralization assays, we developed protocols triggering both types of calcification in vascular smooth muscle cells (SMCs) following diverging molecular pathways.

Materials and methods and results

Human coronary artery SMCs were cultured in osteogenic medium (OM) or high calcium phosphate medium (CaP) to induce a mineralized extracellular matrix. OM induces osteoblast-like differentiation of SMCs–a key process in intimal calcification during atherosclerotic plaque remodeling. CaP mimics hyperphosphatemia, associated with chronic kidney disease–a risk factor for medial calcification. Transcriptomic analysis revealed distinct gene expression profiles of OM and CaP-calcifying SMCs. OM and CaP-treated SMCs shared 107 differentially regulated genes related to SMC contraction and metabolism. Real-time extracellular efflux analysis demonstrated decreased mitochondrial respiration and glycolysis in CaP-treated SMCs compared to increased mitochondrial respiration without altered glycolysis in OM-treated SMCs. Subsequent kinome and in silico drug repurposing analysis (Connectivity Map) suggested a distinct role of protein kinase C (PKC). In vitro validation experiments demonstrated that the PKC activators prostratin and ingenol reduced calcification triggered by OM and promoted calcification triggered by CaP.

Conclusion

Our direct comparison results of two in vitro calcification models strengthen previous observations of distinct intracellular mechanisms that trigger OM and CaP-induced SMC calcification in vitro. We found a differential role of PKC in OM and CaP-calcified SMCs providing new potential cellular and molecular targets for pharmacological intervention in VC. Our data suggest that the field should limit the generalization of results found in in vitro studies using different calcification protocols.
Elevated α-hydroxybutyrate dehydrogenase is associated with in-hospital mortality in non-ischemic dilated cardiomyopathy
Authors: Li Xinyi , He Wenfei , Zhang Xiaonan , Shu Fen , Liu Yaoxin , Tan Ning , Jiang Lei
Published: September 2022

Background

Previous Study Found That Implantation of a Cardioverter-Defibrillator Likely Caused a Worse Prognosis in Older Patients With non-Ischemic Systolic Heart Failure. This Suggests That More Precise Risk Stratification Is Needed in Elderly Patients. We Conducted a Retrospective Study to Evaluate the Association of α-Hydroxybutyrate Dehydrogenase (α-HBDH) With Mortality During Hospitalization in Elderly Patients With non-Ischemic Dilated Cardiomyopathy (NIDCM).

Methods

1,019 Elderly Patients (age ≥60 Years) Diagnosed With NIDCM Were Retrospectively Enrolled From January 2010 to December 2019. Univariate and Multivariate Analyses Were Showed to Explore the Relationship Between α-HBDH and in- Hospital Death.

Results

Patients in elevated α-HBDH group (>182 U/L) had a longer hospital stays and higher in-hospital mortality. Univariate logistics regression analysis showed that elevated α-HBDH was significantly related to mortality (OR: 7.004, 95% CI: 3.583–13.693, p < 0.001). Receiver operator characteristic (ROC) curve analysis reflected that α-HBDH levels had excellent predictive power for in-hospital death (AUC = 0.810, 95% CI: 0.745–0.876, p < 0.001). After adjustment of age, serum creatine, albumin and LVEF, multivariate regression analysis validated the association of elevated α-HBDH with increased risk of in-hospital death (p < 0.05).

Conclusions

Elevated α-HBDH level is significantly related to in-hospital mortality in older patients with NIDCM.
Metabolic syndrome associated with higher glycemic variability in type 1 diabetes: A multicenter cross-sectional study in china
Authors: Guo Keyu , Zhang Liyin , Ye Jianan , Niu Xiaohong , Jiang Hongwei , Gan Shenglian , Zhou Jian , Yang Lin , Zhou Zhiguang
Published: September 2022

Aims

The comorbidity of metabolic syndrome (MetS) and type 1 diabetes mellitus (T1DM) is an obstacle to glucose control in patients with T1DM. We compared glycemic profiles using continuous glucose monitoring (CGM) systems in patients with T1DM with or without MetS.

Methods

This was a multicenter cross-sectional study of patients with T1DM (N = 207) with or without MetS. CGM data were collected from study enrollment until discharge during a 1-week study session. We analyzed baseline HbA1c, average glucose, estimated HbA1c, time in range (TIR), time above range (TAR), time below range (TBR), coefficient of variation (CV), postprandial glucose excursions (PPGE) and other glycemic variability (GV) metrics. Logistic regression was developed to investigate the association between MetS and CGM metrics.

Results

The results showed higher average baseline HbA1c levels, and a higher percentage of patients with baseline HbA1c levels ≥7.5%, in the T1DM with MetS group. Furthermore, MetS was associated with GV, which indicated a higher CV in patients with T1DM with MetS. However, our results showed that TAR, TIR, TBR and other GV metrics were comparable between the two groups. The T1DM with MetS group also had a higher proportion of patients with high CV (≥ 36%) than the group without MetS. In multivariable logistic regression analysis, the presence of MetS was a risk factor for high CV (≥ 36%) in our study participants.

Conclusions

T1DM patients with MetS in our study had better β-cell function. However, MetS was associated with worse glycemic control characterized by higher GV and HbA1c levels. Efforts should be expanded to improve treatment of MetS in patients with T1DM to achieve better glycemic control.
Body mass index, as a novel predictor of hepatocellular carcinoma patients treated with Anti-PD-1 immunotherapy
Authors: Chen Jierong , Lu Lianghe , Qu Chunhua , A Gari , Deng Fangqi , Cai Muyan , Chen Wei , Zheng Lie , Chen Jiewei
Published: September 2022

Immunocheckpoint inhibitors have shown significant efficacy in the treatment of hepatocellular carcinoma (HCC), but there are individual differences. The aim of this study was to explore body mass index (BMI) as a predictor of anti-PD-1 efficacy in patients with HCC. We retrospectively analyzed 101 HCC patients who treated with anti-PD-1 at Sun Yat-sen University Cancer Center from July 2018 to November 2019 and divided them into overweight (BMI > 24.9) and non-overweight (BMI ≤ 24.9) groups based on baseline BMI levels. BMI > 24.9 accounted for 22 cases (21.8%) and BMI ≤ 24.9 accounted for 79 cases (78.2%) in the study cohort. Overweight patients had higher disease control rates than non-overweight patients (P = 0.019, respectively). The mean progression-free survival (PFS) in overweight patients (10.23 months) was significantly longer than that of non-overweight patients (6.85 months; P = 0.027). Among patients with immune-related adverse events (irAEs), the mean PFS was also significantly longer in overweight patients (7.72 months) than in non-overweight patients (5.31 months, P = 0.034). Multivariate analysis showed that BMI was an independent prognostic factor for PFS in HCC patients treated with anti-PD-1 (hazard ratio: 0.47, P = 0.044). Thus, higher BMI predicts a better prognosis among HCC patients treated with anti-PD-1. In clinical practice, patients' BMI can provide a useful tool for predicting the efficacy of anti-PD-1 therapy.
Laser Caliper Reliability in Upper-Stem Diameter Measurements by Multiple Users
Authors: Tereşneu Cornel Cristian , Tudor Ciprian , Vasilescu Maria Magdalena
Published: September 2022

Considering the uncertainty of upper-stem diameter measurements and the fact that there are few studies on the accuracy of diameters using the Mantax Black caliper with Gator Eyes (Haglöf, Långsele, Sweden), the aim of this research is to check laser caliper reliability in upper-stem diameter measurements. The study was conducted in Parc Aventura Braşov (Romania), where a target tree was marked with visible signs at 1 m, 3 m, 5 m, 7 m, 9 m, and 13 m above the ground, and the diameters of the six sections were measured using a conventional caliper and climbing equipment. Later on, 14 forest mensurationists used a laser caliper to measure the diameters of the marked sections 13 m away from the tree, maintaining the direction of measurement. Each user performed repeated independent measurements of the upper-stem diameters, resulting in 14 data sets with 10 values for every section and a total number of 840 observations. Applying ANOVA for all the sections, we found that there are significant differences between the data sets collected by many users, and the pairwise t-test and the Benjamini-Hochberg method showed significant differences. Taking into account the analysis of the individual errors in measuring the upper-stem diameters using a laser caliper, we were able to identify the data sets affected by abnormal errors. By measuring the diameters along the stem up to 13 m above the ground using a laser caliper, one out of 2.4 measurements up to one out of approximately 1.5 was determined with an error below 2 cm. At heights above 5 m, a maximum of one out of five measurements was affected by errors above 4 cm. In addition, it was noted that there is generally a tendency to underestimate the upper-stem diameter and volume estimate when the laser caliper is used for the measurements. The absolute mean error varied between 1.46 cm and 2.52 cm along the stem and the root mean squared error varied between 1.84 cm and 3.04 cm. Nevertheless, general uncertainty about this subject remains, because if we measure upper-stem diameters without contact with the trunk, we will never know whether a single reading shows a negligible error to be used for calibrating taper equations or for increasing volume estimation accuracy. Consequently, we recommend that when used for this purpose, diameters should be measured several times, by experienced users who have proven their skill in measurements that yield smaller errors.
Surgical treatment of spinal CSF-venous fistulas: a systematic review
Authors:   N. N. Burdenko National Medical Research Center for Neurosurgery of the Ministry of Health of the Russian Federation, Konovalov A. N. , Gadzhiagaev V. ,   N. N. Burdenko National Medical Research Center for Neurosurgery of the Ministry of Health of the Russian Federation, Vinogradov E. V. ,   N. N. Burdenko National Medical Research Center for Neurosurgery of the Ministry of Health of the Russian Federation, Nikitin N. Yu. ,   N. N. Burdenko National Medical Research Center for Neurosurgery of the Ministry of Health of the Russian Federation, Eliava Sh. Sh. ,   N. N. Burdenko National Medical Research Center for Neurosurgery of the Ministry of Health of the Russian Federation, Konovalov N. A. ,   N. N. Burdenko National Medical Research Center for Neurosurgery of the Ministry of Health of the Russian Federation
Published: September 2022

CSF-venous fistula is a relatively new and unexplored cause of spontaneous intracranial hypotension syndrome (SIH). The syndrome was first described in 1974 in a patient with chronic lumbar puncture-associated headache after digital subtraction myelography. After 40 years, CSF-venous fistula was considered as the cause of the SIH syndrome in patients with orthostatic headache. CSF-venous fistula is a pathological connection of the subarachnoid space and the adjacent epidural vein or veins. It is one of the top three causes of SIH along with dural defects and meningeal diverticulum. Despite the insufficient assessment of the prevalence of CSF-venous fistulas, some authors consider the syndrome to be the cause of 25 % of the cases. Positional headaches, as well as headaches associated with cough and Valsalva maneuver, are the most common symptoms in patients with CSF-venous fistulas. These patients are characterized by typical MRI signs of intracranial hypotension, such as a clear visualization of pachymeninx, venous congestion, an increase in the size of the pituitary gland, brain sagging syndrome, tonsillar herniation, etc. However, due to the rarity of this disease, algorithms for its diagnosis and treatment have not been established. Management of patients is usually limited to conservative treatment as the first-line method. This includes EBP alone or in combination with fibrin glue. Open surgery for ligation or coagulation of the fistula is used in cases of failed conservative treatment. Endovascular occlusion of the draining vein is a relatively new and less common treatment. The article presents a systematic review of the literature and analysis of the clinical results of various types of treatment for CSF-venous fistulas (EBP, surgical excision and endovascular embolization).
Features of distance learning at the stage of basic general education
Authors:   Department of Roman and Germanic Philology and Methods of Teaching a Foreign Language FSBEI HE Orenburg State Pedagogical University, Makarova Evgeniya Vladimirovna , Vakhrusheva Marina Ivanovna ,   FSBEI HE Orenburg State Pedagogical University
Published: September 2022

This article examines the features of the use of information technology at the stage of basic general education in a distance format. The aim of the study is to substantiate the advantages of introducing distance learning at the stage of basic general education. Particular attention is paid to the consideration of age-related physiological characteristics of pupils of this age period. The interests, motives, and goals of pupils in this age range are presented. The results of the study can be used both in practical pedagogical activities and in further research on the feasibility of using distance learning forms at the stage of basic general education.
Security policy of the critical information infrastructure of Russia and its legal support
Authors:   Baltic State Technical University «Voenmekh» named after V. I. D. F. Ustinova (BSTU «Voenmekh» named after D. F. Ustinov) Russia, St. Petersburg, Ustinovich Elena Stepanovna
Published: September 2022

The Doctrine of Information Security of the Russian Federation of 2016 notes the importance of ensuring the stable and uninterrupted functioning of the information infrastructure in peacetime, during a period of imminent threat of aggression, as well as in wartime. The purpose of protecting critical information infrastructure facilities is to ensure their stable operation in various modes of operation in the face of information security threats. The methodological foundations were the use of general scientific methods of research — analysis and synthesis of information. The sources for this study were scientific articles by Russian scientists and practitioners on information security issues. An interdisciplinary approach was used to achieve the goals of this article. A detailed analysis of the key concepts and theoretical provisions of the policy of ensuring the security of information resources, as well as a comparative analysis of various approaches.
PRESENTACIÓN
Authors: Sequeiros Olivares Karen Abigail
Published: September 2022

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Revascularization in a maxillary lateral incisor using bioceramic sealer: case report
Authors: Marques Eduardo Fernandes , Silva Gabriel Sousa e , Vieira Victor Talarico Leal , Marceliano Eduardo Fagury Videira , Frota Diana Rodrigues Leão , Dantas Wania Christina Figueiredo , Marceliano-Alves Marilia Fagury Videira
Published: September 2022

Revascularization is a regenerative endodontic dental procedure, which aims to stimulate the penetration of periradicular tissue inside the root canal, allowing vascularization of necrotic teeth, leading to a tissue repair and regeneration. Currently, Biodentine cement has been used to perform this procedure. The aim of this study was to report a clinical case about the revascularization of a maxillary lateral incisor with incomplete root formation using Biodentine. The patient, male, 10 years old, attended the multidisciplinary clinic of CEULP/ULBRA accompanied by the responsible, asymptomatic, reporting trauma to element 22, sensitivity and vertical percussion tests were performed with negative results. Through periapical radiography, incomplete root formation and a radiolucent area in the periapical region were observed. The revascularization technique was performed, aiming to stimulate the root formation. In the first session, instrumentation with K-type instruments at working length and intracanal medication were performed. After 15 days, the revascularization procedure was performed with a 25/0.02 K file led beyond the working length to stimulate periapical bleeding, so the canal was filled with blood up to the cervical third. Blood clotting was awaited, Biodentine was placed, and the definitive restoration was performed with composite resin. Follow-up up to 1 year and four months was carried out and the root development was observed. Thus, in the reported case, the revascularization technique proved to be efficient, allowing the continuity of the root formation a compromised tooth.
A Polícia Militar e a participação comunitária na construção de um trânsito mais seguro
Authors: De Souza Maicon Cardoso Mattos
Published: September 2022

A Polícia Militar do Paraná está presente em todos os municípios do Estado desenvolvendo a nobre missão de garantir a segurança aos cidadãos paranaenses. Além do policiamento ostensivo e preventivo, exerce atividades na área de trânsito, possuindo unidades especializadas em trânsito urbano e rodoviário, sendo elas, respectivamente, o Batalhão de Polícia de Trânsito e o Batalhão de Polícia Rodoviária. Logo, em conjunto com outros órgãos e entidades (municipais, estaduais e federais) discriminados no art. 7º da Lei nº 9.503/1997, a Polícia Militar integra o Sistema Nacional de Trânsito. Acontece que existem vários outros órgãos e entidades da sociedade civil que exercem hodiernamente suas atividades na área do trânsito urbano e/ou rodoviário, contudo, não aplicam, de fato, toda essa vivência e conhecimento na busca por um trânsito mais seguro. Tem-se, portanto, que uma atuação integrada e proativa dos órgãos do Sistema Nacional de Trânsito com as entidades civis organizadas como uma forte alternativa para resolução dos problemas de trânsito locais da comunidade, com envolvimento, inclusive, dos Conselhos Comunitários de Segurança, onde demandas pontuais poderão ser trazidas à mesa para discussão, planejamento e providências junto aos órgãos públicos de trânsito.
Impactos da pandemia do COVID-19: uma análise da (IN) solvência das empresas do setor de transporte
Authors: Berwanger Julia Kinast , Gomes Anderson Mendes , Braum Loreni Maria dos Santos
Published: September 2022

O serviço de transportes está entre as atividades essenciais para o funcionamento da economia dos países. A problemática em torno deste estudo está na (in)solvência das empresas do setor de transporte e os impactos decorrentes da pandemia de Covid-19. Portanto, o objetivo do estudo consiste em analisar os indicadores econômico-financeiros do setor de transporte a fim de investigar se as empresas apresentam indícios de (in)solvência no período de 2019 a 2021 em decorrência da pandemia de Covid-19. A fundamentação teórica aborda aspectos sobre análise vertical e horizontal, indicadores econômicos e financeiros, bem como o fator de insolvência no modelo proposto por Kanitz. Quanto aos procedimentos metodológicos utilizou-se quanto aos objetivos, a abordagem descritiva, tendo como procedimentos o estudo multicascos, em que foram analisadas 12 empresas do setor de transporte (modais rodoviário, ferroviário, hidroviário e aéreo) listadas na B3, utilizando-se da pesquisa quantitativa quanto a abordagem do problema. Os resultados revelaram que as empresas do setor de transporte rodoviário, que é o mais utilizado no Brasil, apresentaram os melhores desempenhos econômico-financeiros no período de 2019 a 2021. Em contrapartida, as empresas do modal aéreo, que já vinham apresentando dificuldades antes 2019, foram as mais afetas pela pandemia. Apesar dos impactos gerados pela pandemia no âmbito econômico, nenhuma das empresas analisadas apresentou sinais nítidos de insolvência nos anos de 2020 e 2021. As contribuições do presente estudo foram no sentido de incrementar a literatura científica sobre o contexto da pandemia e os impactos econômico-financeiros causados nas empresas, sobretudo no setor de transporte. Para trabalhos futuros sugere-se que novas pesquisas sejam realizadas a fim de verificar se no período pós-covid as empresas do setor de transportes terão indicadores de desempenho melhores do que os obtidos neste período.
Manejo cirúrgico da obstrução intestinal por íleo biliar
Authors: Lima Barbara Falcetti de , Pacheco Amanda Verçosa , Vargas Ana Elisa Assad Teixeira , Branco Bruno Vinicius Castello , Sales Hélio Gondim de , Silva Isabella Pereira Santos , Vieira Luísa Caroline Soares , Neto Luiza Horst , Barbosa Thaynne Hayssa França , Andrade Thiago Ferrante Rebello de
Published: September 2022

O íleo biliar é uma rara obstrução mecânica do trato gastrointestinal decorrente da impactação de cálculos biliares, podendo ocorrer em qualquer parte deste trato. Sua ocorrência aumenta proporcionalmente à idade e, em decorrência do aumento da expectativa de vida da população, o íleo biliar apresentou crescimento na sua incidência. Manifestada tipicamente por dor em cólica, distensão abdominal, náuseas e vômitos, seus sintomas inespecíficos dificultam um diagnóstico rápido e preciso, resultando em altas taxas de morbimortalidade. A tomografia computadorizada é considerada, atualmente, o padrão ouro no diagnóstico do íleo biliar, entretanto, o diagnóstico também pode ser dado por radiografia, a partir da presença da tríade de Rigler (pneumobilia, distensão de alças intestinais e presença de cálculos radiopacos intraluminais). O principal objetivo terapêutico consiste na extração do cálculo agressor, após a estabilização clínica do paciente. Embora a cirurgia aberta tenha sido estabelecida como método padrão de tratamento, nos dias de hoje, o reparo por endoscopia tornou-se bem aceito, principalmente em pacientes mais frágeis. Entretanto, nos casos em que o método conservador falha ou em cenários de emergência, a cirurgia deve ser realizada prontamente. Esta, por sua vez, pode ser realizada por uma abordagem única, com a extração do cálculo biliar simultânea à colecistectomia e ao reparo da fístula, ou em dois estágios, ou seja, apenas a extração do cálculo biliar e posteriormente o reparo da fístula e a colecistectomia. De qualquer forma, a escolha da melhor conduta deve sempre ser individualizada, levando sempre em consideração a situação do paciente e a localização dos cálculos.
Toxoplasmose e suas repercussões clínicas: uma abordagem materno-fetal
Authors: Araujo João Vitor Gontijo , Araújo Alice Bretas , Bertellotti Giulia da Costa Ribeiro , Freitas Rafaela Maria Pastore de , Benevenutti Letícia , Ribeiro Lara Sousa , Gonçalves Daniella Flávia Alvarenga , Ferreira Esther Marchisotti , Augusto Lorena Reis
Published: September 2022

A toxoplasmose congênita (TC) representa um problema de saúde pública, visto que a transmissão vertical (materno-fetal) pode acarretar em sérios problemas de saúde ao feto ou até mesmo levá-lo a óbito. A doença é causada pelo protozoário Toxoplasma gondii e geralmente é assintomática; entretanto, os riscos ao desenvolvimento fetal justificam o rastreio ativo da toxoplasmose durante a gravidez. Ademais, os riscos de transmissão vertical são maiores em gestantes expostas à infecção primária pelo toxoplasma, em comparação com aquelas que foram expostas à infecção antes da concepção. Nesse sentido, métodos diagnósticos que permitam diferenciar o tempo de exposição ao patógeno, como o teste de avidez IgG, são extremamente importantes para a conduta em relação ao tratamento da doença na gravidez. Além disso, cerca de 85% dos recém nascidos com TC não apresentam sinais clínicos evidentes ao nascimento; entretanto, estudos recentes demonstram que em torno de 19% dos lactentes infectados desenvolvem pelo menos uma manifestação clínica da doença durante o primeiro ano de vida. Dessa forma, quando sintomáticos, os recém nascidos apresentam a clássica tríade de coriorretinite (escotoma, dor, fotofobia, visão turva e lacrimejamento excessivo), hidrocefalia e calcificações intracranianas. Ainda, podem manifestar febre, hepatoesplenomegalia, icterícia, anemia, prematuridade e grave restrição do crescimento intrauterino associado a baixo peso ao nascer. Em relação ao tratamento, o manejo da toxoplasmose depende da imunidade do hospedeiro e do status da doença, por isso existem várias combinações de drogas antiparasitárias e antibacterianas que são utilizadas no controle dessa doença. Outrossim, a prevenção da doença é extremamente importante, medidas profiláticas devem ser recomendadas a todas as gestantes susceptíveis à infecção pelo toxoplasma; concomitantemente, estudos em andamento apontam a possibilidade da invenção de uma vacina no futuro, o que possibilitaria a redução da transmissão da doença e das complicações materno-fetais.
Macrossomia fetal decorrente de diabetes na gestação e suas repercussões após o nascimento: aspectos etiopatogênicos, métodos diagnósticos e medidas preventivas
Authors: Pires Henrique Amaral Fonseca , Santos Larissa Rodrigues , Bonfim Bruna Rezende , Osolins Luciana Furtado , Aquino Isadora Porto de , Nemeth Maria Eduarda Rodrigues Ferreira , Siqueira Yasmin Alves , Carvalho Luciana Azevedo Silva Mantovani de , Santos Thawan Andrelino Nunes
Published: September 2022

As anormalidades do crescimento fetal durante a gestação caracterizam-se como um importante fator preditivo de diversas consequências para o binômio mãe-filho, como traumas durante o parto, cesarianas de emergência, hemorragia pós-parto, além de distúrbios metabólicos, cognitivos e respiratórios fetais. Acerca do crescimento fetal exacerbado, recebe-se a denominação de macrossomia fetal (MF) o feto com peso acima de 4000 g ou 4500 g ou, ainda, feto grande para a idade gestacional (GIG), isto é, acima do percentil 90. Em virtude da variedade etiológica da macrossomia, a epidemiologia é bastante variada e depende de diversos fatores, inclusive das diversidades socioeconômicas e culturais de cada país. Sendo que a incidência está, progressivamente, atingindo níveis alarmantes, o que caracteriza um grave problema de saúde pública. Além disso, a depender da etiologia da MF, a patogênese, as manifestações clínicas e o prognóstico são diferentes. Contudo, vale ressaltar a grande prevalência de MF decorrente de Diabetes Mellitus (DM) durante a gravidez, seja ele pré-gestacional ou gestacional. Frequentemente, o diagnóstico é realizado através das ultrassonografias que são solicitadas durante o pré-natal, as quais permitem a avaliação do peso fetal estimado e sua circunferência abdominal, que são, posteriormente, analisadas em uma tabela específica, comparando com a idade gestacional (IG) em que a mulher se encontra e observando se o feto está ou não acima do percentil 90 para a IG. Devido ao grande índice de morbimortalidade associado a esta condição clínica, medidas preventivas, como recomendação nutricional e atividade física, além de rigoroso controle glicêmico naquelas com DM devem ser instituídas, a fim de minimizar as complicações maternas e neonatais.
Manejo clínico e cirúrgico da Úlcera péptica
Authors: Alves Luiz Fernando , Vargas Ana Elisa Assad Teixeira , Alves Camila Gabriela Rodrigues , Marra Danilo Oliveira , Prazeres Fernanda Amaral , Silva Giovanna Carvalho , Vidal João Vitor Sathler , Ferreira Paula Guimarães , Santos Tayná Alves dos , Paula Thais Viana de
Published: September 2022

A úlcera péptica é definida pela ruptura da barreira defensiva da mucosa epitelial do estômago e duodeno, causada pelo desequilíbrio entre fatores de proteção e de destruição desta. Normalmente, são resultadas de infecções por Helicobacter pylori ou da ação de anti-inflamatórios não esteróides. Essa afecção manifesta-se, tipicamente, por epigastralgia, plenitude pós-prandial, distensão abdominal, náuseas, vômitos, melena e hematêmese. A úlcera péptica é diagnosticada através de seus sinais, sintomas e com a esofagogastroduodenoscopia. Uma vez diagnosticada, a úlcera pode ser tratada por diversas estratégias, a depender de sua etiologia e evolução, podendo variar de mudanças no hábito de vida, como alimentação e cessação do tabagismo e etilismo, a cirurgia, como a vagotomia e gastrectomia. No geral, o tratamento medicamentoso é suficiente para a cicatrização, sendo os inibidores da bomba de prótons os medicamentos de primeira linha. Porém, nos casos em que há infecção por H. pylori, o uso de antibióticos, como claritromicina e amoxicilina, também são indicados. Raramente a cirurgia é necessária, exceto em casos de complicações, como perfuração, suspeita de malignidade e obstrução gastrointestinal, ficando o manejo cirúrgico reservado a esses casos mais complexos.
Analytical Propagation of Space Debris Density for Collisions near Sun-Synchronous Orbits
Authors: Liu Yongjie , Jiang Yu , Li Hengnian
Published: September 2022

The increasing frequency of human launches has led to a dramatic increase in the amount of space debris, especially near sun-synchronous orbits. Most of the fragments are small in size, which may make tracking difficult. Therefore, characterizing the distribution, evolution, and collision risk of small debris has long been a difficult issue. This paper is aimed at investigating the orbital evolution and global dispersion behavior of debris clouds near sun-synchronous orbits. Firstly, the NASA breakup model is used to provide an initial distribution of small fragments after collision events. Secondly, the continuity equation is adopted to propagate the density variation analytically. Furthermore, we introduce some statistical quantities and the entropy of debris clouds to model the randomness and band formation. A theorem concerning the equivalence of the band formation and maximal entropy is presented. The accuracy of the band formation time estimation is also discussed. For noncatastrophic collisions at an altitude of 800 km due to a projectile with a mass of 100 g and a collision velocity of 1 km/s, we compare the analytical and numerical results of space debris density. The results show that the maximal peak error is within 0.17, and the mean square error is about 0.25 at 400 days. Additionally, the entropy of right ascension of the ascending node is 8.5% less than that for debris clouds near an orbit with the same altitude and an inclination of 30 deg. This indicates the concentrating behavior for debris clouds near sun-synchronous orbits.
Внутреннее положение Станиславовского воеводства в 1921-1923 гг = Vnutrenneye polozheniye Stanislavovskogo voyevodstva v 1921-1923 gg
Authors: PULIK Paweł
Published: September 2022

Stanislawow province was one of the borderland provinces of The Second Polish Republic and was part of Eastern Małopolska. This area was inhabited by people of several nationalities - Ukrainians, Poles, Jews and Germans but the dominant group were Ukrainians. The fact that the numerical superiority of the Ukrainian population over the other nationalist groups shaped to a large extent, the internal situation of the province Stanislawow. Its manifestation in the first period of the province in the years 1921-1923 were the attitudes of the population towards the important events that took place on its territory. Their example was especially avoiding the Ukrainian population from participating in the census in 1921, and the boycott by a significant percentage of Ukrainians parliamentary elections in 1922. The reason for such behavior of the Ukrainian community was among its vulnerability to anti-Polish propaganda, conducted by the Ukrainian environmental disagreeing with the nationality of Eastern Małopolska to the Polish, as well as the fear of the consequences of terrorist actions organized by the Polish state hostile to the Ukrainian militia. On the attitude of the population of other nationalities Stanislawow province consisted of both loyalty, indifference as well as looking at taking action of their own interests.
Создание Третьей Бригады Легионов Польских. Обстоятельства создания и обзор снаряжения = Sozdaniye Tret'yey Brigady Legionov Pol'skikh. Obstoyatel'stva sozdaniya i obzor snaryazheniya
Authors: WIERZBICKI Sławomir , PULIK Aleksiej
Published: September 2022

The aim of this work is not be exhaustive, but merely a subjective show the history of military formations existing in the years 1915-1917 he was the Third Brigade of the Polish Legions. On the basis of archival materials and scientific literature the author presents the constitution of the unit, which played an important role in the struggle for Polish independence in the First World War. The work is presented in both aspects of the purely military and political background related to the struggle for Polish Legions character. Initially, the author puts forward for consideration a preliminary reflection. Then present the formation of Polish organization of shooting in Galicia. In the next part discusses the circumstances surrounding the creation and the beginnings of the Polish Legions and the genesis of the Third Brigade of the Polish Legions. At the end of the focuses its attention on uniforms and equipment Legions.
The effect of water bodies and water courses on WWII warfare in the Black Sea area between 1941 and 1942
Authors: SIEBIESZUK Damian
Published: September 2022

The subject of the analysis is German and Soviet military operations in the southern sector of the eastern front, with a particular emphasis on the role of rivers and the Black Sea, during these operations. The time frame of the paper includes the beginning of Operation Barbarossa, in June 1941, until the capture of the Crimean peninsula by the Wehrmacht, in July 1942. The article begins with an attempt of defining concepts relevant for further study of the issues mentioned in the title. The role of the Black Sea and its watercourses is discussed and the fact that they played a very important role as defensive lines of the Red Army. The German army showed its huge military potential when crossing rivers. Military operations performed at the Black Sea became an integral element of the fights in the southern sector of the eastern front. The means of warfare involved as well as human and material losses may indicate a ruthlessness of the fighting and importance of the Black Sea theatre of war. Efforts and dedication of the both warring sides in the area of the Black Sea made history.
Э.Ш. Хуршудян, Государственные институты парфянского и сасанидского Ирана, Алматы 2015 = E.Sh. Khurshudyan, Gosudarstvennyye instituty parfyanskogo i sasanidskogo Irana, Almaty 2015
Authors: MAKSYMIUK Katarzyna
Published: September 2022

Book Review
New Russian view on Sassanid Empire. Polemic with book: М. Мочалов, Д. Полежаев, Держава Сасанидов 224 - 653 годы, Москва 2016 = New Russian view on Sassanid Empire. Polemic with book: M. Mochalov, D. Polezhayev, Derzhava Sasanidov 224 - 653 gody, Moskva 2016
Authors: SIŃCZAK Tomasz
Published: September 2022

Polemic
Szkoła Rycerska Kadetów Jego Królewskiej Mości i Rzeczypospolitej, red. W. Bednaruk, K. Jaszczuk, Lublin 2016
Authors: PIŁATOWICZ Józef
Published: September 2022

Book Review
To idzie młodość. Młodzież w ideologii i praktyce komunizmu, red. D. Magier, Lublin/Radzyń Podlaski 2016
Authors: WILKOWSKI Eugeniusz
Published: September 2022

Book Review
A. G. Dąbrowski, Kancelaria Ministerstwa Spraw Wewnętrznych w Warszawie w latach 1918-1939, Warszawa 2015
Authors: MAGIER Dariusz
Published: September 2022

Book Review
Świadkowie przeszłości ziemi siedleckiej (biogramy)
Authors: WAGNER Marek , DMOWSKI Rafał , ZAWADZKI Arkadiusz , WŁODARKIEWICZ Wojciech , ROGALSKI Artur
Published: September 2022

Biographies of people born or related to activities in the area of Southern Podlasie and Eastern Mazovia.
Representations of Antique Arms and Armour in the Architectural decor of St. Petersburg
Authors: NIKONENKO Sergey
Published: September 2022

The matter of the article is the representation of ancient arms and armour in Saint Petetrburg’s architecture. Classisism style (1770-1840) and New Classicism style (1905-1915) are studied. The main point of the article is the representation of helmets in military décor. The article contains: 1. Typology of ancient military décor; 2. The full list of buildings with ancient military décor of Saint Petersburg; 3. Examples of ancient helmets in military décor of Saint Petersburg; 4. Aesthetical Analysis of the art, symbolic and ideological reasons for using ancient military décor in Saint Petersburg’s buildings; 5. The attempt to prove that archaic helmets are the most frequent kind of Saint Petersburg’s military décor; 6. The attempt to prove that Russian architects and sculptors did not copy ancient helmets and other arms but they created new samples according to the canons of Classicism art.
Zarys dziejów Izraela
Authors: ŚLEDŹ Tomasz
Published: September 2022

The aim of the publication is to present the research conducted by history students at the University of Siedlce. "Outline of Israel's History" - is an extended abstract of BA thesis.
Struktura, uzbrojenie i wyposażenie 1 Dywizji Piechoty Legionów w przededniu wybuchu II Wojny Światowej
Authors: PAJKA Przemysław
Published: September 2022

The aim of the publication is to present the research conducted by history students at the Siedlce University. "Structure, armament and equipment of the 1st Legions Infantry Division on the eve of the outbreak of World War II" is an extended abstract of BA thesis.
Rodzynkowe bombowce nad Berlinem
Authors: MALINOWSKI Remigiusz
Published: September 2022

The aim of the publication is to present the research conducted by history students at the Siedlce University. "Raisin bombers over Berlin" is an extended abstract of BA thesis.
Sprawozdanie z Ogólnopolskiej Konferencji Naukowej pt. „Procesy modernizacyjne w Europie Środkowo-Wschodniej w perspektywie historycznej”
Authors: SIEBIESZUK Damian
Published: September 2022

Overview and description of the Regional Scientific Conference "Modernization processes in Central and Eastern Europe in a historical perspective" at Siedlce University (2017.03.08)
Państwo bez stosów. Czy z doświadczeń polskich w zakresie tolerancji religijnej i kulturowej może czerpać współczesna Europa?
Authors: JUCHIMIUK Hubert
Published: September 2022

"A state without the stake. Can modern Europe draw from Polish experiences in the field of religious and cultural tolerance?" - The work was awarded the first prize in the competition commemorating "A jubilee year of 500 years of the Reformation" announced by the Institute of History and International Relations of the University of Natural Sciences and Humanities in Siedlce.
Państwo bez stosów. Czy z doświadczeń polskich w zakresie tolerancji religijnej i kulturowej może czerpać współczesna Europa?
Authors: SITKOWSKI Łukasz
Published: September 2022

"A state without the stake. Can modern Europe draw from Polish experiences in the field of religious and cultural tolerance?" - The work was awarded the first prize in the competition commemorating "A jubilee year of 500 years of the Reformation" announced by the Institute of History and International Relations of the University of Natural Sciences and Humanities in Siedlce.
تقيد القضاء الدستوري بضابط الضرورة القصوى وفق أسلوب الدفع الفرعي
Authors: عبد اليمه عبد الحميد , بهجت مها
Published: September 2022

ان الرقابة على دستورية القوانين مقيدة بمجموعة من الضوابط، ومن بينها ضابط عدم ممارسة الرقابة إلا عند الضرورة القصوى، ويتحقق التقيد بهذا الضابط عندما يتم التقيد بشروط الدفع الفرعي، التي تتمثل بجدية الدفع الفرعي، وضرورة تحقق المصلحة الشخصية المباشرة، أي عندما يكون الفصل في الدعوى الأصلية لازما ً للفصل في الدعوى الموضوعية، ولا يكون كذلك مالم يكن الدفع جدياً ويحقق مصلحة شخصية مباشرة لأحد أطراف الدعوى الأصلية، كما لابد من التقيد بتقديم الدعوى الدستورية خلال الموعد المحدد بالنسبة للدول التي تشترط ذلك مثل مصر.
نظرية المخاطر كأساس للمسؤولية الدولية عن أعمال مجلس الأمن المشروعة دولياً والمتسمة بخطورة استثنائية
Authors: علي هديل , نعيم هادي نعيم المالكي
Published: September 2022

تنهض المسؤولية الدولية بحق منظمة الأمم المتحدة عن أعمال مجلس الأمن وفقا لنظرية المخاطر وذلك في حالة تسيير السفن والغواصات وحاملة الطائرات التي تعمل بالطاقة النووية بحق الدول المخالفة لأحكام ميثاق الامم المتحدة، باعتبار أعمال المجلس هنا تعد من قبيل الأعمال المشروعة دوليا المتسمة بخطورة استثنائية والتي قد يلجأ اليها المجلس لضمان السرعة والفعالية المشار اليها في المادة (11/ فقرة 2) من الميثاق ومواكبة للتطورات التكنولوجيا الحديثة
مسؤولية حائز العقار في الرهن التأميني
Authors: مهدي قتيبة , عبدالله حسين
Published: September 2022

من المعلوم إن تسجيل حق رهن على عقار لا يؤدي الى منع الراهن من التصرف في العقار المرهون، فالراهن يستطيع التصرف في العقار المرهون بعد تسجيل التأمين العيني عليه ، ولكن تصرفه لا يؤثر في حق صاحب التأمين العيني ، فهو تصرف غير نافذ في مواجهته لأنه جاء بعد تسجيل الرهن على الرغم من إن التصرف يكون صحيحا وينتج جميع آثاره بين المتصرف (( الراهن )) والمتصرف إليه (( الحائز )) والسبب في ذلك يعود الى انه لو اعتبرنا التصرف الصادر من الراهن غير صحيح فان هذا يؤدي الى الانتقاص من حق الراهن في التصرف ، فالحائز وان كان يملك العقار الذي يحوز ملكا تاما ، ويتمتع بكل مقومات عناصر الملكية ، ومن سلطات الاستعمال والاستغلال والتصرف ، الا ان هذا الوضع القائم لا يجرده من كل الاثار القانونية التي قد تنشأ عن هذه العلاقة القائمة ، فالحائز الذي تلقى ملكية العقار من السلف انما تلقاها بعد الرهن ، وهي مثقلة بحق للغير ، دون ان يكون مسؤولا شخصيا عن الدين الموثق بالرهن . فالحائز من حيث الاصل غير مسؤول عن حقوق الدائنين ، لان الحائز غير مسؤول عما يصيب ملكه ، ولكن لان الحائز يعتبر خلفا خاصا للراهن في هذا المال ، فان التزام الراهن بضمان الرهن ينتقل مع العقار المرهون الى الحائز وفقا للقانون ، باعتباره التزاما يحد من ملكية هذا العقار ، فيسأل الحائز كما يسأل الراهن عما يصيب العقار المرهون ، كذلك فان الحائز يسأل عما يصيب العقار من ضرر اذا تعمد او اهمل في ذلك . اذا فان مسؤولية الحائز قد تتحقق قبل الدائن المرتهن في اي وقت طالما ان حق الرهن لا يزال قائما على العقار المرهون.
دور المصرف الوسيط في اطار قواعد الحوكمة المصرفية
Authors: عامر ياسر , نافع خالص
Published: September 2022

يعد سوق الأوراق المالية فضاء رحب لعمل المصارف بوصفها وسيط يمارس تداول الأوراق المالية لصالح عملاءه، ولما كان الوسيط كشخصية معنويه عبارة عن مصرف، فكان لا بد لهذا البحث من استعراض قواعد الحوكمة التي يلتزم بتطبيقها المصرف الوسيط ، سواء على مستوى تنظيم شخصية الوسيط وتعيين العاملين ضمن هذه الوظيفة، والالتزام بالشروط التي يلزم توافرها في شخصية الوسيط ومساعديه ، أو تطبيق قواعد الحوكمة المصرفية على مستوى المهام التي يكلف بها الوسيط في اطار عمله في سوق الأوراق المالية سواء بشكل مباشر او غير مباشر.
جزاء الإخلال بالوعد بالتعاقد في ضوء تعديل القانون المدني الفرنسي بموجب المرسوم رقم 131 لسنة 2016
Authors: عبدالله احمد , مطشر علي
Published: September 2022

يُعد الإخلال بالوعد بالتعاقد والجزاء المترتب على هذا الإخلال من المواضيع المهمة التي شغلت حيزاً واسعاً من اهتمام فقه  القانون المدني  عند دراسته  لموضوع الوعد بالتعاقد ، ولم تغب هذه الأهمية عن ذهن القضاء فكانت حاضرة في قراراته ، وترجع هذه الأهمية الى خصوصية الوعد بالتعاقد فعلى الرغم من كونه عقداً كسائر العقود إلا أن الأخلال به يتميز بطبيعة خاصة ، فهو قد يتم  قبل مرحلة إبداء الرغبة من جانب الموعود له وقد يكون بعد إبداء تلك الرغبة . وإنطلاقاً من هذه الأهمية سيكون  جزاء الإخلال بالوعد بالتعاقد موضوع هذا البحث .
ПИТАННЯ РОЗВИТКУ АНДРАГОГІКИ У СПАДЩИНІ АЛЕКСАНДРА КАППА
Authors: Матулчик Юліус
Published: September 2022

Оглядова стаття присвячена аналізу першої концепції андрагогіки, яку розробив Александр Капп і візуалізував у праці «Вчення Платона про освіту як педагогіку особистості та як державну педагогіку або її практичну філософію» у 1833 р. З’ясовано, що автор концепції андрагогіки інтерпретує її зміст в дусі метафізичного ідеалізму ідеї Платона про навчання впродовж усього життя, водночас багато його поглядів відрізняються від сучасної теорії андрагогіки. Особлива увага у статті приділена аналізу змісту наукової праці загальним обсягом 474  сторінки, і містить дві основні частини: навчання про освіту для індивідів і державну педагогіку. Перша частина складається із трьох розділів: пропедевтика або освіта до народження; специфічна педагогіка; андрагогіка або освіта дорослих. Доведено, що за результатами аналізу цих розділів, в основу структурування своєї праці Александр Капп поклав онтогенетичний принцип розвитку людини. Педагогіку та андрагогіку автор розуміє як рівноправні сфери, що охоплюють навчання дітей і підлітків (педагогіка) та освіту дорослих (андрагогіка). Друга частина роботи присвячена вивченню і аналізу таких характеристик державної освіти як: державна освіта набуває негайної дії, державна освіта через суспільне життя, державна освіта через правила життя всіх класів, державна освіта через дію на державу як таку. У праці знайдено низку ідей, які можна розглядати як елементи теоретичного визначення освіти дорослих: самопізнання як перша вимога до людини,  формування характеру людини через освіту, виховання чоловіків до професії і в професії, виховання чоловіка на роль батька сімейства. Встановлено, що А. Капп бачив андрагогічне поле діяльності саме в освіті чоловіків, а не в освіті дорослих загалом. Він повністю виключав жінок із системи навчання. Основою саморозвитку дорослої людини О. Капп вважав самопізнання. Доведено, що андрагогіка О. Каппа має лише символічне історичне значення для сучасної андрагогіки, проте її позитивні ідеї варто використати для модернізації освіти дорослих у різних країнах світу.

Ключові слова: андрагогіка; виховання; дорослий; освіта дорослих; Александр Капп.