bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Evaluation for Effectiveness and Safety of Lidocaine and Bupivacaine Combination Epidural Infusion for the Management of Post-Total Hip Replacement Pain
Authors: Alsaadi Malath , Hasan Mohannad Ali , Mehsen Jameel , Aliakbar Adil
Published: July 2022

Background
The management of post-operative pain is critical for both the patient and the surgical outcome. Although epidural analgesia is valuable method, optimal local anesthetic selection and combination could improve its effectiveness. To determine the effectiveness and safety of bupivacaine and lidocaine bolus epidural analgesia in the management of post-total hip arthroplasty.
Methods         
65 Records of patients who underwent total hip arthroplasty and received bolus epidural analgesia with bupivacaine and lidocaine were evaluated retrospectively. The numerical pain score for 48 hours, drug adverse effects, hospital stay, and opioid intake were analyzed statistically to determine the effectiveness and safety of epidural analgesia.
Results
The numerical pain score showed mild pain perception through the first 48 hours post operatively. There was no significant difference (p≥ 0.005) between the first score data collected at 6 hours and the last score at 48 hours. Post-operatively, patients had lower incidence of hypotension and headache with acceptable mobility. Opioid rescue analgesia was used for 11(16.9%) of patients.
Conclusions
For patients who have undergone total hip replacement surgery, epidural analgesia with a bolus epidural infusion of lidocaine and bupivacaine delivers an effective and safe pain control method for 48 hours. This method was effective in opioid sparing.
The Severity of COVID-19 and its Correlation with Inflammation Biomarkers
Authors: Indra Beni , Lipoeto Nur Indrawaty , Hardisman Hardisman , Putra Andani Eka , Tjong Djong Hon , Rahman Sukri , Yusri Elfira , Bilhaq Muhammad Ridho , Pratama Yusan , Risman Yudha
Published: July 2022

Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov2) or Covid-19 has been spread quickly and caused 5 million deaths until February 2022. Severe symptoms of the infection may lead to death that prompt appropriate clinical diagnosis and adequate treatment going to be necessary. Covid-19 shows a severe inflammatory response which causes an imbalance in the immune response. Therefore, circulating biomarkers that can represent inflammation and immune status are potential predictors for the prognosis of COVID-19 patients. This study aims to know the role of Neutrophil-Lymphocyte Ratio (NLR), Neutrophil Monocyte Ratio (NMR), and Lymphocyte-monocyte Ratio (LMR) as inflammatory biomarkers for the severity of Covid-19.
Methodology: This study is a single-center retrospective cohort study. The sample of this study was taken by consecutive sampling with complete clinical data from 893 Covid-19 patients from Andalas University Teaching Hospital from April 2020 to September 2021. This study uses SPSS Version 25.0 for data management and analysis.
Result: Most of the degrees of Covid-19 infection were mild degrees as many as 597 people with an NLR average value of 2.07 (0.27-34.50), and NMR average value of 7.86 (3-46), an LMR average value of 3.67 (0.25-25), an ANC value of 3.990 (945-45). 14,608).  Most of the degrees of infection in patients with negative PCR results were moderate degrees as many as 70 people with a mean NLR value of 9.0694 (0.51-47.50), a mean NMR value of 18.6199 (1.15-47.50), and a mean LMR was 3.0324 (0.29-19.50), the ANC value was 9769.73 (1.088-37,219). There was a relationship between the degree of Covid-19 infection and the NLR value (p=0.144), as well as the LMR (p=0.000), NMR(p=0.000), and ANC (p=0.000). There was no relationship between the degree of infection in the negative PCR patient group and the NLR value (p=0.000), as well as the LMR (p=0.700), NMR(p=0.120), and ANC (p=0.90).
Conclusion: The severity of Covid-19 symptoms could be predicted through inflammatory biomarkers such as NLR, LMR, and NMR.
Cardiovascular Disease Risk Profiles in Indonesian Athletes
Authors: Achmad Bayu Fandhi , Alim Syahirul , Kusumawati Happy Indah , Fitriawan Akbar Satria , Kurniawan Dedi , Kafil Raisa Farida
Published: July 2022

BACKGROUND: Notwithstanding how physical exercise lessens cardiovascular and all-cause mortality, young and active athletes might have cardiovascular risk factors or fundamental cardiovascular diseases (CVDs), putting them at increased risk for sudden cardiac death during times of strenuous exercise.
AIM: The study aimed to assess the cardiovascular risk profile possessed by Indonesian athletes.
METHODS: This research was a quantitative study using a cross-sectional design, involving 234 Indonesian athletes (163 men and 71 women) from three sports, including football, basketball, and swimming. Data were collected between December 2020 to March 2021 using the Jakarta Cardiovascular Risk Score instrument adapted from the Framingham risk score. Descriptive statistics were utilized to dissect data information for frequency distribution, percentage, mean, and standard deviation.
RESULTS: Most of the participants in this study had excessive weekly exercise duration (more than 255 minutes/week) (n=177 athletes, 75.64%). Twenty-one participants (8.97%) had a higher MAP more than normal, and 51 participants (21.79%) had overweight BMI. In addition, 142 participants (60.68%) had a cardiovascular genetic disease from their parents (family history) and most of the participants also were active smokers (n=150, 64.10%). Based on the Jakarta Cardiovascular Risk Score, the Indonesian athletes who participated in this study had a mean cardiovascular risk of -1.5 (SD= 3.088, min-max= (-7) – 6). Most of the participants had low cardiovascular risk (n= 193, 82.48%). However, some participants had moderate and high cardiovascular risk, 32 (13.67%) and 9 (3.85%), respectively.
CONCLUSION:  Most of the participants had low cardiovascular risk, however some of the participants had moderate and high cardiovascular risk.
Molecular identification and phylogenetic relationships of Colletotrichum isolates pathogenic on cultivated plants in Bulgaria
Authors: Manova Vasilissa , Stoyanova Zornitsa , Boycheva Irina , Rodeva Rossitza , Bonchev Georgi
Published: July 2022

Fungi of the genus Colletotrichum are causal agents of plant diseases with constantly growing economic importance. Accurate pathogen identification is a significant prerequisite for effective disease control. The aim of the present investigation was to clarify the species affiliation of Colletotrichum isolates obtained from different hosts in Bulgaria and to determine the phylogenetic relationships between them by applying DNA barcoding. Thirty-five fungal isolates obtained from five botanical families (Solanaceae, Rosaceae, Musaceae, Cucurbitaceae and Caryophyllaceae) were morphologically characterized and subjected to molecular analysis based on four fungal barcode markers – the primary ITS barcode and the secondary marker regions ACT, EF-1a and TUB2 (Fig. 1). Three of the barcodes (ITS, ACT and TUB2) showed complete success rate of PCR amplification and sequencing and proved efficient for reliable identification at species level. BLAST analyses identified eleven Colletotrichum species assigned to five different complexes – C. coccodes, C. acutatum, C. gloeosporioides, C. dematium and C. spaethianum. The resolution power of ITS region was not sufficient to discriminate interspecies variations within C. coccodes, C. dematium and C. spaethianum complexes confirming the requirement for secondary barcodes in order to resolve the genetic variability of the Colletotrichum isolates. DNA barcoding analyses revealed that the highest species variation was observed among the isolates from pepper (Capsicum annuum). Interestingly, an isolate from the same host identified as C. truncatum on the basis of morphological characters appeared to be C. circinans when applying DNA barcode markers. According to our knowledge, this species has not been reported as a causal agent of pepper anthracnose. Data obtained in this study improve our understanding of the genetic diversity within the Colletotrichum population pathogenic on cultivated plants in Bulgaria.
Genetic diversity in high-mountain Thymus species in Bulgaria revealed by ISSR genetic markers
Authors: Zhelev Petar , Bonchev Georgi , Aneva Ina
Published: July 2022

High mountain populations of the plant species possess particular interest from both evolutionary and conservation points of view. The mode of distribution, limited gene flow and severe environmental conditions act as evolutionary forces shaping the level and distribution of genetic diversity within and among populations. The paper reports results of a study on four populations of Thymus praecox aggr., including the taxa T. vandasii and T. jankae. Two populations are located in Rila Mts (Belmeken dam and Yastrebets), one – in Pirin (Vihren hut) and one – in the Rhodopes (Perelik hut). Eleven inter simple sequence repeat (ISSR) markers were applied to document the genetic diversity within and among populations. The level and distribution of the diversity correspond to the values reported in other studies on the species of the genus Thymus and other species with similar life-history characteristics. The populations from Rila and Pirin were genetically closer to each other, while the population from the Rhodopes was the most differentiated. The results are discussed in the light of the conservation and sustainable use of the species resources.
Trends in the proportion of women as reviewers, editors, and editorial board members of 15 North American and British medical journals from 2014 to 2019: A retrospective study
Authors: Wang Roxanna , Roberts Robin , Fredenburgh James C , Cushman Mary , Weitz Jeffrey I
Published: July 2022

Background and objective: There is persistent men-dominated gender disparity in medical academia. Predominance of men in the editorial makeup of medical journals might contribute to this inequity. This retrospective study (2014–2019)

sought to evaluate gender representation in reviewers, editors, and members of the editorial boards in 15 leading medical journals from the United States, Canada, and the United Kingdom.

Methods: We surveyed lists of reviewers, editors, and editorial board members from seven journals of internal medicine, a specialty dominated by men; three journals  of obstetrics and gynaecology and two of paediatrics, specialties dominated by women; and three journals of psychiatry, a gender-balanced specialty. Information from publicly available resources was used to infer gender, and the percentages of women were calculated. Trends over time were characterized by changes in these percentages from year to year through the linear regression line fitted to the data for each journal.

Results: Journals of women-dominated specialties had significantly higher proportions of women reviewers than those of men-dominated or gender-balanced specialties, with mean percentages (95% confidence interval) of 45.8% (40.5%–51.1%), 28.0% (22.3%–33.7%), and 33.8% (27.6%–40.1%), respectively (p <0.001). The proportion of women editors and editorial board members showed no statistically significant differences across the three specialties, and the percentage of women reviewers, editors, and editorial board members increased only slightly over time.

Conclusion: These results suggest that the fifteen journals are yet to achieve gender parity in their reviewers, editors, and editorial board members, and continued efforts are needed to achieve gender balance in those three groups of medical academia.
Extension of the phasmid genus Presbistus to Cambodia with a new species and notes on genitalia and captive breeding (Phasmida, Aschiphasmatidae, Aschiphasmatinae)
Authors: Bresseel Joachim , Constant Jérôme
Published: July 2022

A new species ofPresbistusKirby, 1896,Presbistus vitivorussp. nov., is described from Cambodia based on both sexes, nymphs, and eggs. Male genitalia and vomer are described and figured. Illustrations of adults, nymphs, specimens in situ, host plants, a distribution map and records on biology and breeding in captivity are provided. The host plants of the species belong to the family Vitaceae. The genusPresbistusand the family Aschiphasmatidae are recorded from Cambodia for the first time. The species diversity and the distribution of the genus are discussed, and it is shown that the genus is restricted to Sundaland. A nomenclature for the morphology of the dissected vomer is proposed and tries to homologize the previously used terms.
Synthesis, docking study, and structure-activity relationship of novel niflumic acid derivatives acting as anticancer agents by inhibiting VEGFR or EGFR tyrosine kinase activities
Authors: Yaseen Yahya , Kubba Ammar , Shihab Wurood , Tahtamouni Lubna
Published: July 2022

A new series of niflumic acid (NF) derivatives were synthesized by esterification of (NF) to give ester compound 1, which was treated with hydrazine hydrate to produce (NF) hydrazide 2. Hydrazine-1-carboxamide compounds (3A–C), and hydrazine-1-carbothioamide derivatives (4A–D) were synthesized by treatment of (NF) hydrazide with phenyl isocyanate, and phenyl isothiocyanate derivatives, respectively. The cyclization of (4B–D) and (3B) was achieved using NaOH solution to produce 1,2,4-triazole derivatives (5A–C) and 6, respectively. The prepared compounds were characterized using IR, 1HNMR, 13CNMR, and MS (ESI) spectroscopy. A molecular docking study was performed to evaluate the binding affinity of the synthesized compounds against EGFR and VEGFR kinase domains which revealed that compounds 3B, and 4A had the best binding energy (-7.87, and -7.33 kcal/mol, respectively) against VEGFR, while compound 5A had the best binding energy (-7.95 kcal/mol) against EGFR. The biological investigation results indicated that all the tested compounds caused cell killing in the two cancer cell lines (Hep G2 and A549) studied, with compound 4C being the most cytotoxic, as well as being cancer selective. Additionally, compound 4C-treated Hep G2 cells were arrested at the S and G2/M cell cycle phases. Cytotoxicity of compound 4C was attributed to apoptosis as determined by flow cytometry and qRT-PCR results of the apoptosis markers p53, BAX, and caspase-3. Finally, compound 4C inhibited VEGFR kinase activity, while compound 5B inhibited EGFR kinase activity. In conclusion, the novel (NF) derivatives are potent anticancer agents, inhibiting cell proliferation by inhibiting EGFR and VEGFR tyrosine kinase enzymes.
Eppur si muove . Circulation transnationale des réformes de l’enseignement supérieur entre organisations internationales et espaces nationaux
Authors: Dakowska Dorota
Published: July 2022

Cet article propose de réexaminer la thèse de la circulation transnationale des dispositifs d’action publique relatifs à l’enseignement supérieur en prenant en compte à la fois les cadres internationaux de réforme et leur réception dans des espaces nationaux. L’attention portée aux relations entre les organisations internationales (OI) – Conseil de l’Europe, OCDE, UNESCO ainsi que la Commission européenne – permet d’interroger les stratégies qu’elles déploient pour maintenir leur autorité dans un domaine qui relève des prérogatives historiques des États. Le cas de l’enseignement supérieur, secteur d’action publique secondaire dans l’espace transnational, offre un prisme heuristique pour analyser les relations de dépendance des OI vis-à-vis des États et d’autres bailleurs de fonds. Or, la relative fragilité du positionnement des OI dans ce domaine ne les empêche pas de développer des dispositifs ambitieux pour comparer les systèmes nationaux et mesurer leur performance. Les recommandations construites dans l’espace transnational trouvent une résonnance dans les espaces nationaux analysés (français, polonais et ukrainien). C’est cette double énigme que l’article interroge à l’appui d’une enquête empirique multisituée.
The Use of Simulation-Based Education With New Graduate Nurses in Emergency Department and Acute Care Settings: A Scoping Review
Authors: Rutherford-Hemming Tonya , Herrington Alaina , Newsome Lindsey
Published: July 2022

Background

The literature questions if newly graduated nurses are truly ready to practice at the bedside. Simulation has been shown to bridge the gap between theory and practice. The purpose of this study was to investigate what is known about the use of simulation education with novice graduate nurses in critical care settings in the hospital.

Method

A scoping review was conducted using the PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Articles published in English between 2015 and September 2021 that focused on simulation education with novice graduate nurses in a critical care setting were included.

Results

The review yielded six articles.

Conclusion

The literature is scant on the use of simulation in critical care areas with novice graduate nurses. Additional inquiry is needed related to the role of learners, cost, timing, setting, and educational practices. More studies with stronger research designs and valid and reliable measurement instruments are also needed. Finally, there is a need to better understand the effects of simulation on novice nurse graduates' knowledge and skills as well as patient outcomes.

[
J Contin Educ Nurs
. 2022;53(7):301–306.]
Implementation of a Registered Nurse Primary Care Clinical Mentoring Academy
Authors: Daniel Shawona C. , Reese Alveta V. , Bowers Deborah , Pollio E. Whitney , Stover Nichols Lynn M. , Patton Emily , Johnson Cori Cunningham , Bruck Meg , Shirey Maria R.
Published: July 2022

Registered nurses (RNs) are pivotal team members for improving the quality of care in communities; however, they are underutilized in primary care. Two schools of nursing in Alabama partnered to develop and implement a project to build a resilient primary care RN workforce. A major component of this project is the Primary Care Clinical Mentoring Academy (PCCMA), which was designed to prepare RN clinical mentors to implement positive student learning experiences in the primary care setting. The PCCMA follows a comprehensive curriculum implementing both didactic instruction and interactive activities related to primary care competencies; interprofessional education and collaborative practice; and primary care RN mentor roles and responsibilities. Participants reported that the PCCMA was effective and useful, and they perceived that it would improve their overall job performance as a clinical mentor. The PCCMA is an effective way to produce confident and capable RN mentors in primary care.

[
J Contin Educ Nurs
. 2022;53(7):312–320.]
Diffusive size-structured population model with time-varying diffusion rate
Authors: Kumar Manoj , Abbas Syed
Published: July 2022

This work is devoted to the study of a size-structured population model with a time-varying diffusion rate. Due to the seasonal variation, it is natural to consider the time-varying diffusion rate. Moreover, introducing the time-varying diffusion rate makes the model more challenging and requires the results of evolution operators for the analysis. Under some assumptions on the time-dependent diffusion coefficient, the existence and uniqueness of mild solution is shown. We apply the method of characteristics and evolution operators to derive our results. Positivity and boundedness of mild solution is also shown. Some examples are provided to illustrate the theoretical findings. We also solve our model numerically to study the size and spatial dynamics of population density.
Biofilms: Formation, drug resistance and alternatives to conventional approaches
Authors: Mirghani Ruba , Saba Tania , Khaliq Hebba , Mitchell Jennifer , Do Lan , Chambi Liz , Diaz Kelly , Kennedy Taylor , Alkassab Katia , Huynh Thuhue , Elmi Mohamed , Martinez Jennifer , Sawan Suad , Rijal Girdhari
Published: July 2022

Biofilms are aggregates of bacteria, in most cases, which are resistant usually to broad-spectrum antibiotics in their typical concentrations or even in higher doses. A trend of increasing multi-drug resistance in biofilms, which are responsible for emerging life-threatening nosocomial infections, is becoming a serious problem. Biofilms, however, are at various sensitivity levels to environmental factors and are versatile in infectivity depending on virulence factors. This review presents the fundamental information about biofilms: formation, antibiotic resistance, impacts on public health and alternatives to conventional approaches. Novel developments in micro-biosystems that help reveal the new treatment tools by sensing and characterization of biofilms will also be discussed. Understanding the formation, structure, physiology and properties of biofilms better helps eliminate them by the usage of appropriate antibiotics or their control by novel therapy approaches, such as anti-biofilm molecules, effective gene editing, drug-delivery systems and probiotics.
From the sea, to the river, through the desert
Authors: Oller Guzmán Joan
Published: July 2022

The Smaragdus region was the only known source of emeralds in the Roman Empire. This paper deals with several aspects of the extraction and commercialization of this gemstone in the Egyptian Eastern Desert in the Roman period. Through the analysis of different sources of information, including the latest archaeological data available, we will discuss aspects such as emerald mine workers, the ownership issue and changes in the trade network in the Late Roman period.
Pourquoi classer les facultés de l’esprit ? André-Marie Ampère : de la science à la philosophie et vice versa
Authors: Braverman Charles
Published: July 2022

André-Marie Ampère est connu pour ses travaux en électrodynamique. Cependant, il a accordé beaucoup d’importance à la réflexion philosophique, non seulement à travers une classification des sciences, mais aussi par une tentative de classification des facultés intellectuelles. Il s’agit donc d’interroger l’importance du paradigme classificatoire, chez Ampère, et de montrer qu’il est synonyme d’une pratique scientifique à appliquer en philosophie. Toutefois, c’est à travers son activité philosophique classant les facultés intellectuelles qu’Ampère fonde une épistémologie qui rend légitimes les usages de la classification pour connaître les rapports constitutifs de la réalité. Enfin, l’espoir d’une classification naturelle implique la rigueur d’une induction empirique et une mathématisation des rapports. Cette mathématisation est alors elle-même justifiée par la classification des facultés qui finit par mettre en exergue l’importance de la notion d’intuition.
La logique est-elle une science de classification ? Sur une crise de la classification dans la logique au xixe siècle
Authors: Chevalier Jean-Marie
Published: July 2022

La classification relève traditionnellement de l’étude de la logique. Mais à quel titre exactement ? Une réponse consiste à considérer que la logique opère par excellence sur des classes, et qu’à ce titre elle constitue la science générale des classifications. Telle est la conception que véhicule via Porphyre la logique classique d’inspiration scolastique. Le xixe siècle est venu bouleverser ces habitudes. D’une part, les sciences empiriques élaborent des taxinomies indépendantes de la connaissance abstraite ou a priori que peuvent fournir les logiciens, au point que ce sont plutôt ces derniers qui viennent puiser des méthodes dans la chimie, la botanique ou la minéralogie. D’autre part, le développement de la logique symbolique a renouvelé la compréhension de la logique elle-même : sans être une théorie générale de la classification, elle est en revanche susceptible de recourir à une classification de ses objets propres (ensembles, fonctions, symboles, etc.).
Une classification selon l’ordre et la forme : Jules Bourgoin et l’art ornemental
Authors: Boucard Jenny , Eckes Christophe
Published: July 2022

L’architecte et ornemaniste Jules Bourgoin élabore un vaste projet de classification des motifs ornementaux dans sa Théorie de l’ornement (1873). Dans cet article, nous analysons les principes introduits par Bourgoin pour classer des ornements. Ainsi, Bourgoin s’inspire principalement de la « théorie de l’ordre », intimement liée à l’étude des combinaisons, qui fut introduite par Louis Poinsot à la fin des années 1810 puis développée par Antoine-Augustin Cournot quelques années plus tard. Par ailleurs, dans son projet théorique, Bourgoin se réfère à diverses classifications d’objets issues de domaines scientifiques variés, dont les mathématiques, la cristallographie ainsi que la botanique. Enfin, nous proposons une clarification de l’attitude de Bourgoin à l’égard des sciences formelles et des sciences de la nature et de leurs rapports à l’art ornemental.
Les représentations des tatouages connectés: enjeux de l’acceptabilité et relation à l’imaginaire
Authors: BOUTET-DIÉYE Annabelle , SEZNEC Aurélie
Published: July 2022

Cet article présente les résultats d’une enquête exploratoire à propos des tatouages connectés mené en partenariat avec Mathilde Sarré-Charrier du laboratoire SENSE du groupe Orange. Il met de l’avant deux univers, a priori très éloignés, celui du tatouage et celui des innovations numériques. Mais, après des recherches sur les innovations récentes en matière d’objets connectés, nous avons émis l’hypothèse de convergences possibles entre les deux univers. En effet, alors que la pratique du tatouage se répand dans toutes les sphères de la société, elle séduit également les laboratoires de recherche et de développement, de même que les entreprises du numérique. Dans cet article, en nous appuyant sur des entretiens semi-directifs et un état de l’art sur le numérique vestimentaire et cosmétique (wearable), nous proposons d’interroger ce que représentent les tatouages connectés dans la [re]définition du rôle social du corps. Les discours des personnes interviewées mettent en lumière l’importance de prendre en compte l’imaginaire social pour mieux saisir ce qui est en jeu dans l’acceptabilité du phénomène et pour cerner les ambivalences relevées en ce qui a trait aux innovations relatives aux tatouages connectés.
Pour une approche nouvelle de la conception de dispositifs pour le suivi de maladies chroniques
Authors: CATOIR-BRISSON Marie-Julie , WREMBEL Elisa , RICCIO Pierre-Michel
Published: July 2022

À partir d’une réflexion sur le concept de dispositif, notre article invite à s’interroger sur certaines approches de la conception et à analyser leur mise en œuvre concrète dans le champ de la santé et du bien-être, à travers deux exemples d’objets connectés (Fitbit et Apple Watch). Constatant d’abord que certains dispositifs de santé mobile ne sont pas adaptés aux utilisateurs, nous présentons ensuite le programme de recherche Som’Health, centré sur les troubles chroniques du sommeil, que nous menons depuis 2016. Sur la base de ce travail de terrain, nous proposons une approche nouvelle de la conception de dispositifs en santé mobile pour le suivi des maladies chroniques, en nous appuyant sur deux modèles théoriques : la théorie de l’utilisation et l’éthique de la conception.
Reconsidération d’une recherche en codesign : négociations, tensions, incertitudes et questionnements
Authors: GERMAIN Hélène , DEL CAMPO Natalia
Published: July 2022

Cet article rend compte des écarts entre les ambitions initiales d’un projet de recherche international visant le développement d’objets connectés pour l’accompagnement de personnes vivant avec la maladie de Parkinsons au cours de sa mise en œuvre en France. Nous y présentons la composition du collectif de recherche hybride, ses objectifs et les enjeux auxquels il est confronté. Les modalités de prise en compte des savoirs expérientiels sont remises en question. Les aspects éthiques liés à l’implémentation des objets connectés dans le domaine de la santé sont abordés. L’article met en avant les négociations, tensions, incertitudes et questionnements qui émergent au fil des échanges entre les acteurs impliqués.
Notificações de incidentes relacionados à segurança do paciente em hospital universitário sentinela/Notifications of incidents related to patient safety in a sentinel university hospital
Authors: Garcia Izabela Melo , Pimentel Rafael Rodrigo da Silva , Aroni Patrícia , Dias Alexsandro de Oliveira , Silva Larissa Gutierrez de Carvalho , Haddad Maria do Carmo Fernandez Lourenço
Published: July 2022

Objetivo: analisar as notificações de incidentes relacionados à segurança do paciente em hospital universitário público sentinela. Método: pesquisa retrospectiva, quantitativa, realizada em hospital universitário localizado no Sul do Brasil. Foram analisadas 760 notificações de incidentes ocorridos nos anos de 2015 a 2017 encaminhadas ao setor de gerência de risco da instituição. Os dados foram coletados de maio a agosto de 2018. A análise estatística descritiva se realizou com o auxílio do Statistical Package for the Social Sciences versão 20.0. Resultados: os incidentes notificados foram lesão por pressão (64,0%), seguida de quedas (25,0%), erro de medicação (9,7%), identificação incorreta do paciente (1,0%) e incidentes nos procedimentos cirúrgicos (0,3%). O período matutino, profissional enfermeiro e a unidade de terapia intensiva adulto foram os que mais realizaram as notificações. O evento adverso mais notificado estava relacionado ao erro de medicação (50,7%) seguido de quedas (26,8%). Conclusão: os resultados deste estudo contribuem para aumentar o interesse na análise dos dados de incidentes e eventos adversos, bem como para definir ou refinar as estratégias de melhoria da segurança do paciente.
Implantação das linhas de cuidado para a organização do serviço: contribuições da norma regulamentadora 440 / Implementation of the lines of care for the organization of the service: contributions of the regulatory standard 440
Authors: Jamile da Silva Kátia , Farina Fabiele , Cristiane Vanzin Maykler , Vendruscolo Carine
Published: July 2022

Objetivo: relatar a experiência da implantação de Linhas de Cuidado com base na Resolução Normativa (RN) 440, em um serviço de Atenção Primária à Saúde (APS) Suplementar. Método: estudo qualitativo, de caráter descritivo, que consiste em um relato de experiência sobre o processo de implantação das Linhas de Cuidado com base na RN 440, de janeiro a abril de 2020. O processo de estruturação foi realizado por duas enfermeiras, durante quatro meses, para a organização dos fluxos, protocolos e processo de trabalho da equipe, norteado pelo Manual de Certificação de Boas Práticas em APS de Operadoras de Planos Privados de Assistência à Saúde. Discussão: a adesão à certificação deu direcionamento para a reestruturação da APS com base legal e científica em todos os âmbitos do serviço. Levando em consideração a população alvo do serviço e o perfil epidemiológico, foram estabelecidas quatro Linhas de Cuidado: Saúde da Mulher; Saúde Mental; Hipertensos e Diabéticos. Considerações finais: um desafio nesse processo é a inserção da cultura de autocuidado e do entendimento do usuário frente a esse modelo de atenção. Sugere-se a realização de pesquisas sobre a Certificação em Boas Práticas da APS Suplementar, devido à escassez de estudos sobre a temática.
A EDUCAÇÃO INTEGRAL COMO FUNÇÃO DO PEDAGOGO QUE ATUA NA REINTEGRAÇÃO SOCIAL DO APENADO ASSISTIDO NO PATRONATO MUNICIPAL DE APUCARANA
Authors: Nascimento Lícia Beatriz do , Salvaterra Adriana , Fernandes Maria Nilvane
Published: July 2022

O artigo objetiva discutir a importância da concepção de educação integral e o papel da Pedagogia no processo de reintegração social dos apenados assistidos no Patronato Municipal de Apucarana. Sabemos que o papel do pedagogo historicamente esteve atrelado à educação escolar, todavia, nos últimos anos, seu campo de atuação ampliou-se de modo significativo. O Patronato, como um órgão de execução penal, também se configura em uma nova área de atuação desse profissional que se identifica, cada vez mais, como um trabalhador da área social. O pedagogo, no âmbito social, apoia o assistido no desejo de retornar ao convívio social, viabilizando o acesso ao conhecimento científico por meio dos estudos e/ou cursos profissionalizantes, articulando, portanto, educação escolar e não escolar. Trata-se de uma pesquisa que utiliza como estratégia a análise bibliográfica e o detalhamento de dados documentais coletados sobre os assistidos entre os anos de 2013 a 2018. Os resultados, para além de um impacto imediato na vida dos assistidos, demonstraram que os encaminhamentos do setor pedagógico para a rede de serviços contribuíram para viabilizar uma melhor integração social, o que valida a importância do trabalho pedagógico realizado por meio da educação integral com os egressos do Patronato.
UMA ANÁLISE DE UM PROGRAMA DE AVALIAÇÃO EXTERNA E EM LARGA ESCALA DIGITAL
Authors: Freitas Iranete Gabriela Almeida Silva Fernandes de , Garcia Paulo Sergio
Published: July 2022

Este estudo analisa o Programa Prova São Caetano Digital, a partir de seus documentos e estrutura, e da compreensão de professores e de gestores. Trata-se de um Programa de avaliação do desempenho dos alunos realizada no município de São Caetano do Sul. Para tal foi utilizada a pesquisa qualitativa, a partir de um questionário qualitativo para estudar a diversidade das opiniões. Possibilidades e desafios foram localizados. No primeiro grupo, estavam maior rapidez na entrega dos resultados e na organização de encontros para a discussão dos dados, favorecendo uma tomada de decisão mais rápida; maior monitoramento do desempenho do aluno; economia de papel, entre outros. No segundo, problemas com a conexão com a internet, formação de professores e de gestores. Os dados desta pesquisa podem ser discutidos nas secretarias e diretorias de educação para a implementação de recursos tecnológicos para o monitoramento dos alunos.
Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to IFN Types I, II, and III
Authors: Constant David A , Van Winkle Jacob A , VanderHoek Eden , Dekker Simone E , Sofia M Anthony , Regner Emilie , Modiano Nir , Tsikitis V Liana , Nice Timothy J
Published: July 2022

The three types of IFN have roles in antimicrobial immunity and inflammation that must be properly balanced to maintain tissue homeostasis. For example, IFNs are elevated in the context of inflammatory bowel disease and may synergize with inflammatory cytokines such as TNF-α to promote tissue damage. Prior studies suggest that in mouse intestinal epithelial cells (IECs), type III IFNs are preferentially produced during viral infections and are less cytotoxic than type I IFN. In this study, we generated human IEC organoid lines from biopsies of ileum, ascending colon, and sigmoid colon of three healthy subjects to establish the baseline responses of normal human IECs to types I, II, and III IFN. We found that all IFN types elicited responses that were qualitatively consistent across intestinal biopsy sites. However, IFN types differed in magnitude of STAT1 phosphorylation and identity of genes in their downstream transcriptional programs. Specifically, there was a core transcriptional module shared by IFN types, but types I and II IFN stimulated unique transcriptional modules beyond this core gene signature. The transcriptional modules of type I and II IFN included proapoptotic genes, and expression of these genes correlated with potentiation of TNF-α cytotoxicity. These data define the response profiles of healthy human IEC organoids across IFN types, and they suggest that cytotoxic effects mediated by TNF-α in inflamed tissues may be amplified by a simultaneous high-magnitude IFN response.
Clinical Mental Health Measures and Prediction of Postconcussion Musculoskeletal Injury
Authors: Buckley Thomas A. , Bryk Kelsey N. , Enrique Alexander L. , Kaminski Thomas W. , Hunzinger Katherine J. , Oldham Jessie R.
Published: July 2022

Context

The rate of lower extremity musculoskeletal injury (LE MSK) is elevated after concussion; however, the underlying mechanism has not been elucidated. Physical characteristics have been investigated despite poorer mental health being a common postconcussion complaint and linked to MSKs.

Objective

To evaluate the role of mental health as a predictor of postconcussion LE MSK.

Design

Case-control study.

Setting

Intercollegiate athletic training facility.

Patients or Other Participants

A total of 67 National Collegiate Athletic Association Division I student-athletes (n = 39 females) who had been diagnosed with a sport-related concussion.

Main Outcome Measure(s)

The Brief Symptom Inventory-18, Hospital Anxiety and Depression Scale, and Satisfaction With Life Scale (SWLS) measures were completed at baseline (preseason) and on the day participants were cleared for unrestricted return to play (RTP) after a concussion. Two binary logistic regressions were used to predict postconcussion LE MSK within a year, one for the baseline time point and the second for the RTP time point. A 2 (group: LE MSK, no LE MSK)-by-2 (time: baseline, RTP) repeated-measures analysis of variance compared performance between baseline and RTP.

Results

Subsequent LE MSKs were sustained by 44 participants (65.7%). The only significant predictor of postconcussion LE MSK was the SWLS score at RTP, with Exp(B) = 0.64, indicating that an increased (improved) SWLS score was associated with a lower LE MSK rate. No significant interactions were present between mental health measures and subsequent MSK (P values = .105–.885).

Conclusions

Limited associations were evident between postconcussion LE MSK and scores on commonly used measures of anxiety, depression, and satisfaction with life. Reported increased satisfaction with life was associated with a decreased injury risk, which warrants further attention. Our results suggest that these measures of anxiety, depression, and satisfaction with life have limited value in assisting sports medicine clinicians with determining which student-athletes are at elevated risk of postconcussion LE MSK.
Left Ventricular Chordae Tendinae Myxoma Causing Stroke
Authors: Suraci Nicholas , Lee Rebecca
Published: July 2022

A 52-year-old woman presented with dysarthria and right-sided weakness in her upper and lower extremities prompting thrombolytic therapy with mild resolution of symptoms. Further work-up revealed (the source) a left ventricular myxoma on the chordae tendinae of the posterior medial papillary muscle, confirmed with transesophageal echocardiography and pathology. Herein, we present a rare case of embolic stroke from a myxoma originating on the chordae tendinae. To the best of our knowledge, the literature on the location and presentation of this tumor as seen in our patient is sparse in contemporary findings.
A Case of COVID-19 STEMI Complicated by Second
Authors: Ibrahim Elkholy Ibrahim Mahmoud , Al-Jarallah Mohammed , Dashti Raja
Published: July 2022

We present a case of a coronavirus disease 2019 (COVID-19) patient who presented with acute myocardial infarction and was treated successfully with primary percutaneous intervention and stent implantation. During the hospital stay, the patient did not develop respiratory manifestations either clinically or radiologically. This report highlights the effect of COVID-19 disease on the cardiovascular system and its effect beyond common respiratory complications.
HELLP Syndrome in Pregnancy
Authors: Humtsoe Zuchanbeni
Published: July 2022

HELLP is an acronym that refers to a syndrome characterised by haemolysis, elevated liver enzymes and a low platelet (HELLP) count. It is a rare and life-threatening condition that occurs during pregnancy. The most common symptoms of HELLP syndrome include headache, nausea, vomiting, upper right abdominal pain, tenderness and fatigue. Most symptoms and side effects subside within 2–3 days of delivery. Early identification and treatment is essential to prevent complications of HELLP syndrome.
Resilience amongst the Elderly during the COVID-19 Pandemic Lockdown
Authors: Metha J. , Kumari T. Priscilla Prema , Meenakshi P. , Savarimuthu Rogina J. S.
Published: July 2022

Many old people live with challenges, poor health and hardship in their life. In spite of the crisis and losses, they tend to experience low impact as compared to the general population, which may be accounted to their resilience. Resilience is achieving the same level of functional ability as such of the pre-crisis state. A study was conducted online to assess resilience amongst the elderly during the COVID-19 pandemic lockdown in a selected rural community area, Chengalpattu district, Tamil Nadu, India. A descriptive research design was used. The sample size was 67. Convenient sampling technique was adopted. The demographic profile and the Connor-Davidson Resilience Scale-25 were used as data collection instruments. Many older people showed moderate levels of resilience, and the mean score was 57.86. Gender and educational status and family income were significantly associated with resilience.
Management of Maintenance Hemodialysis Patients under the Coronavirus Disease Pandemic
Authors: Xiong Fei , Tu Can
Published: July 2022

Abstract

Coronavirus disease (COVID-19) has spread worldwide and has resulted in high mortality, increased pressure on medical systems, and severe global economic losses. Hemodialysis patients may be highly susceptible to infections due to old age, immunocompromised status, preexisting comorbidities, and frequent hospital visits. Moreover, the closed and crowded environment of dialysis rooms increases the risk of cross-infections. The Wuhan Hemodialysis Quality Control Center has accumulated valuable experience in the prevention and control of the COVID-19 epidemic and has normalized management of the epidemic since early 2020. In this review, we garnered experiences and knowledge from China and worldwide to summarize an approach to COVID-19 prevention, control, and management in hemodialysis patients under normalized epidemic conditions.
Therapeutic Effect of Tocilizumab on Inhibiting Cytokine Release Syndrome in Severe Coronavirus Disease 2019 Patients
Authors: Xu Lengnan , Liu Xin , Zhou Yangwei , Liu Aihua , Xu Xiaomao , Wang Xiaoxia , Zhong Xuefeng , Qiao Yu , Wen Li , Xi Huan , Mao Yonghui
Published: July 2022

Abstract

Background and Objectives:

Older adults are more susceptible to coronavirus disease 2019 (COVID-19). Interleukin-6 (IL-6) is an important cytokine in the cytokine release syndrome (CRS), and tocilizumab blocks the IL-6 receptor. The objective is to analyze the effect of tocilizumab on CRS in older patients with severe COVID-19.

Materials and Methods:

Between February 10 and March 21, 2020, a total of 19 patients aged ≥60 years with severe or critical COVID-19 met the study inclusion criteria at the Tongji Hospital in Wuhan City, Hubei Province, China. The patients were divided into two groups: the tocilizumab group, with IL-6 levels, which exceeded the upper limit of normal by >10-fold and non-tocilizumab group.

Results:

Patients in the tocilizumab group were older (73.20 ± 4.44 vs. 66.21 ± 5.06 years, P = 0.014), had lower lymphocyte counts (0.71 ± 0.18 vs. 1.18 ± 0.59 × 109/L, P = 0.016), and higher high-sensitivity C-reactive protein (hsCRP) levels (94.04 ± 57.24 vs. 51.65 ± 45.37 mg/L, P = 0.035). Increases in ferritin (FER) and hsCRP levels in patients in the tocilizumab group were marked. Except for one patient who died, IL-6, FER, hsCRP levels, and the neutrophil/lymphocyte ratio in the remaining four patients decreased following treatment with tocilizumab. Tocilizumab did not cause any serious adverse reactions. There were no differences in mortality, days until lung computerized tomography improvement, or renal function between the two groups. The total mortality rate was 10.53%.

Conclusions:

Our results support the therapeutic efficacy and safety of tocilizumab in older patients with severe COVID-19.
The origin of a complex breccia body within the Upper Cretaceous/Early Eocene succession on Pag Island (Karst Dinarides, Croatia): karstic dissolution and collapse or dilational faulting and collapse origin?
Authors:   Department of Geology, Faculty of Science, University of Zagreb, Croatia, Kurtanjek Dražen , Bucković Damir ,   Department of Geology, Faculty of Science, University of Zagreb, Croatia, Tibljaš Darko ,   Department of Geology, Faculty of Science, University of Zagreb, Croatia, Cvetko Tešović Blanka ,   Department of Geology, Faculty of Science, University of Zagreb, Croatia
Published: July 2022

A kilometre west of Pag Town on Pag Island, Croatia, within the Upper Cretaceous shallow-water carbonate succession, there is a large breccia body that has an irregular, quasi-circular shape and a subvertical-oblique position in relation to the bedding of the host rock. The breccia clasts and fragments consist almost entirely of the Upper Cretaceous host rock with only sporadic clasts of the Lower Eocene foraminiferal (alveolinid) limestones. In the brecciated body, there are three breccia types. 1) crackle breccia, 2) mosaic breccia, and 3) chaotic breccia. Based on the textural and structural characteristics of these types of breccia such as chaotic appearance and random fabric, very poorly sorted material, angular fragments, the composition reflecting only the host rock lithology, two genetic scenarios or concepts for the origin of Pag Town breccia body were considered, with observations supporting each of them. The first concept involves host rock dissolution resulting in a widened dissolution cavity into which wall and roof rocks progressively collapsed, and the second concept involves the collapse of voids produced by dilational fault displacement. A common prerequisite to both opposing scenarios is the existence of a subsurface cavity or void where the accumulation of rock clasts and fragments occurred. It is assumed that the timing of the cavity formation is related mainly to karstification during the Late Cretaceous-Early Eocene emersion phase or is related to dilational faulting during the Palaeogene Dinarides thrusting event.
Geological potential of antimony, bauxite, fluorite, and magnesite of the Central Dinarides (Bosnia and Herzegovina): exploration and exploitation perspective
Authors:   Faculty of Mining Geology and Petroleum Engineering, University of Zagreb, Croatia, Borojević Šoštarić Sibila , Markelj Anže ,   Geology Survey of Slovenia, Ljubljana, Slovenia, Jašarević Eldar ,   Mining Institute Tuzla, Bosnia and Herzegovina, Haindl Angelika ,   Department Mineral Resources Engineering, Montanuniversität Leoben, Austria
Published: July 2022

This paper presents the critical raw materials (CRM) potential of antimony, bauxite, fluorite, and magnesite deposits in Bosnia and Herzegovina, discusses their metallogeny and joint geological features, and explains the methodology of the InvestRM application and evaluation criteria for the selected commodities in the following steps: (1) preparation of the geological data templates, (2) evaluation and verification of the geological data, (3) ranking of deposits according to the geological data relating to quality and quantity, and (4) identification of the 10+ perspective deposits. Existing geological datasets show the existence of significant potential in primary CRM such as bauxite (56 Mt), magnesite (4 Mt), and antimony (0.2 Mt) in Bosnia and Herzegovina (BiH). The geological settings of BiH provide favourable metallogenetic conditions primarily for bauxite and magnesite deposits but also for antimony within polymetallic deposits, while fluorspar is rather rare. Our methodology described herein led to the selection of the following fourteen deposits for further geological prospection and investment: the polymetallic antimony deposits Čemernica and Podhrusanj, antimony fields Srebrenica and Rupice; magnesite fields Kladanj, Banja Luka, Teslić and Novi Šeher and bauxite regions Vlasenica-Srebrenica, Grmeč Mountain deposits in Una-Sana region and South Bosnia regions from Posušje to Trebinje. A basic economic calculation based on the world producer ranking and a self-sustainability and economic contribution assessment shows that further investments in geological exploration and mining of antimony, magnesite, and bauxite CRM could place BiH on the list of important producers of these commodities in Europe.