bluuebunny/crossref_metadata_2025 huggingface dataset:
Wrightia vietnamensis (Apocynaceae), a new species from Vietnam
Authors: Hazell Emily C. , Baines Richard A. , Nguyen Van Dzu , Francis Jessica V. , Middleton David J.
Published: August 2023

A new species of Wrightia (Apocynaceae) from Vietnam, Wrightia vietnamensis Hazell & D.J.Middleton, is described and illustrated. Seed was collected on a Vietnamese led international collaborative expedition and grown on in the Temperate House at the Royal Botanic Gardens, Kew. When it matured and flowered, it was found to be an undescribed species. The species is currently only known from one karst limestone locality. This restricted distribution conforms to regional patterns of speciation and endemism in the genus whereby species restricted to karst limestone have very restricted distributions and those found on other soil types have wider distributions.
Federated deep Q-learning networks for service-based anomaly detection and classification in edge-to-cloud ecosystems
Authors: AL-Naday Mays , Dobre Vlad , Reed Martin , Toor Salman , Volckaert Bruno , De Turck Filip
Published: August 2023

The diversity of services and infrastructure in metropolitan edge-to-cloud network(s) is rising to unprecedented levels. This is causing a rising threat of a wider range of cyber attacks coupled with a growing integration of a constrained range of infrastructure, particularly seen at the network edge. Deep reinforcement-based learning is an attractive approach to detecting attacks, as it allows less dependency on labeled data with better ability to classify different attacks. However, current approaches to learning are known to be computationally expensive (cost), and the learning experience can be negatively impacted by the presence of outliers and noise (quality). This work tackles both the cost and quality challenges with a novel service-based federated deep reinforcement learning solution, enabling anomaly detection and attack classification at a reduced data cost and with better quality. The federated settings in the proposed approach enable multiple edge units to create clusters that follow a bottom-up learning approach. The proposed solution adapts a deep Q-learning network (DQN) for service-tunable flow classification and introduces a novel federated DQN (FDQN) for federated learning. Through such targeted training and validation, variation in data patterns and noise is reduced. This leads to improved performance per service with lower training cost. Performance and cost of the solution, along with sensitivity to exploration parameters, are evaluated using examples of publicly available datasets (UNSW-NB15 and CIC-IDS2018). Evaluation results show the proposed solution to maintain detection accuracy in the range of ≈75–85% with lower data supply while improving the classification rate by a factor of ≈2.
Impact of prolonged heating on the color and crystallinity of bone
Authors: Gallo G. , Ushakov S. V. , Navrotsky A. , Stahlschmidt M. C.
Published: August 2023

Duration of an anthropogenic fire event is one aspect of fire use and maintenance that is linked to combustion feature function but has low archaeological visibility. In this study, we describe the transformations to fresh, modern cortical bone with prolonged exposure to heat in order to evaluate the utility of archaeological bone for the recognition of long duration thermal alteration. Cores of bovid cortical bone were heated exposed to air at 300, 550, and 750 °C in a sequence of experimental trials in a Nabertherm muffle furnace for periods of 10 minutes, 9 hours, and 48 hours, plus an extensive cooling period on heat retaining sediments (gravel or gravel compacted with fine quartz sand) to mirror the smoldering and extinguishing of actualistic fires. After heating, bone cores were analyzed with a color tool, Fourier-transform infrared spectroscopy, and X-ray diffraction to evaluate changes in structure, composition, and crystallinity of bioapatite as a function of different temperature thresholds and time. Results indicate that prolonged heating in air induces specific structural and chemical changes in bone compared to shorter duration burned counterparts. Coloration changes also demonstrate that white coloration, a primary characteristic utilized by zooarchaeologists to record information about burning intensity, is not an exclusive indicator of calcination at moderate to high temperatures but may also result from long duration exposures at low temperatures.
Calculation of penetration depth of a support retaining system anchored on the top, for underground network and buried energy pipelines
Authors: Zachos Dimos , Alamanis Nikolaos , Papageorgiou Grigorios , Chrysanidis Theodoros , Xafoulis Nikolaos , Paschalis Evangelos
Published: August 2023

The object of the present paper is to determine the minimum support requirements provided for the safe execution of trench excavation works for underground network receptacles. This term is used to define the open excavations, which are carried out for underground networks to be installed or constructed, and which are classified in terms of place of execution and soil categories. This paper focuses on the study of the free earth support method in excavations carried out in earthy soils and in places where the passage of the pipeline requires deep excavations of vertical front. In these cases, for reasons of safety of both the personnel and the equipment, it is necessary to support the vertical excavation fronts, even when the analyses indicate their stability. In this context, and to avoid the consequences, before the start of the excavation and at its limit, the formation of vertical support structures is required, which are commonly known as "retaining bulkheads". The basic criteria for selecting the type of the support system are soil characteristics, local conditions (surface load, groundwater table) and finally, the lifetime of the trench. Based on the above, the objective of the study is to investigate the temporary support of vertical fronts of depth trenches about 10 m, the excavation of which is carried out on earthy soil. The study is based on the implementation of the limit equilibrium method, which is applied according to the provisions—guidelines set out in Eurocode 7 (EN 1997). The study investigates the distribution of earth pressures in an anchored retaining structure of a deep excavation by extracting the main design parameters of similar systems. The goal of this work is to select the type of the support system depending on the soil properties (c, γ, φ and Ε) and local conditions, as a prerequisite for safe and rational design, while in the end of the project useful conclusions are drawn.
Development of decomposition-based model using Copula-GARCH approach to simulate instantaneous peak discharge
Authors: Nazeri Tahroudi Mohammad , Mirabbasi Rasoul
Published: August 2023

Estimation of instantaneous peak discharge is important in the design of hydraulic structures and reservoir management. In this study, a new approach called CEEMD-Copula-GARCH is presented for simulating instantaneous peak discharge in the Qale Shahrokh basin, upstream of Zayanderood Dam, Iran. In the developed method, the Complementary ensemble empirical mode decomposition (CEEMD) algorithm was used to analyze the observed values and generate the intrinsic mode function values and residual series. For this purpose, the intrinsic mode function values were simulated based on vine copula and its tree sequence (C-vine, D-vine, R-vine and their independent and Gaussian modes), and the residual series of the CEEMD algorithm were simulated by the GARCH model. The results of simulating instantaneous peak discharge values (m3/s) using the CEEMD-Copula-GARCH approach in the study area showed that the amount of simulation error based on the RMSE statistic compared to the CEEMD-Copula model and simulation without decomposition has improved by about 20 and 70%, respectively. The model’s efficiency was also estimated based on the Nash–Sutcliffe efficiency in the proposed approach of 0.99, and the certainty of the proposed approach was also confirmed based on the presented violin plot. According to the presented results, the proposed approach has high accuracy and efficiency in the simulation of instantaneous peak discharge (m3/s), which can be used in the flood control system design and flood management. Using the methodology proposed in this study, multivariable models can be used in simulating univariate series with high accuracy.
Energy intensity-based metric for optimal design of water distribution systems
Authors: Marlim Malvin S. , Kang Doosun
Published: August 2023

Water distribution systems (WDSs) are some of the most energy-intensive urban infrastructures and thus require efficient energy management. As an essential public infrastructure, a WDS plays an integral role in meeting the water needs of its users at service pressure. Hence, the service level should also be considered when reducing the energy consumption of the WDS. Therefore, to evaluate both energy management and service level, this study proposes efficient returned pressure (ERP) as a metric to optimize the WDS in both aspects by comparing the service pressure to the required energy intensity. During its operating cycle, the ERP considers the pressure and required energy intensity of the demand junctions resulting from the connection of various WDS elements. Using ERP as an optimization objective against the cost for three cases of different active network element configurations, it was discovered that ERP successfully identified solutions that could maximize service pressure while maintaining a minimum required energy intensity. Using ERP provided more effective solutions in terms of cost, greenhouse gas emissions, and network pressure uniformity compared to a conventional index such as the modified resilience index. Overall, the ERP proves to be a feasible optimization parameter when pressure and energy usage is of concern.
Real-time, random-access organ screening for carbapenem-resistant organisms (CRO) reduces CRO-associated, donor-derived infection mortality in lung transplant recipients
Authors: Zhou Wen-Yong , Shen Lei , Shi Jian-Xin , Gao Xing-Hui , Yang Jun , Fu Shi-Jie , Pan Xu-Feng , Zhu Min-Fang , Zhang Shen , Zhang Chong , Li Feng , Zhang Hai , Yao Feng , Tenover Fred C. , Tang Yi-Wei , Fang Wen-Tao
Published: August 2023

Purpose

Donor-derived infection (DDI) has become an important factor affecting the prognosis of lung transplantation patients. The risks versus benefits of using donor organs infected with multidrug-resistant organisms (MDRO), especially carbapenem-resistant organisms (CRO), are frequently debated. Traditional microbial culture and antimicrobial susceptibility testing at present fail to meet the needs of quick CRO determination for donor lungs before acquisition. In this study, we explored a novel screening method by using Xpert® Carba-R assay for CRO in donor lungs in a real-time manner to reduce CRO-associated DDI mortality.

Methods

This study was registered on chictr.org.cn (ChiCTR2100053687) on November 2021. In the Xpert Carba-R screening group, donor lungs were screened for CRO infection by the Xpert Carba-R test on bronchoalveolar fluid (BALF) before acquisition. If the result was negative, donor lung acquisition and subsequent lung transplantation were performed. In the thirty-five potential donors, nine (25.71%) with positive Xpert Carba-R results in BALF were declined for lung transplantation. Twenty-six recipients and the matching CRO-negative donor lungs (74.29%) were included in the Xpert Carba-R screening group. In the control group, nineteen recipients underwent lung transplants without Xpert Carba-R screening. The incidence and mortality of CRO-associated DDI were collected and contrasted between the two groups.

Results

Multivariate analysis showed that CRO-related death due to DDI within 60 days was significantly lower in the Xpert Carba-R screening group than that in the control group (OR = 0.05, 95% CI 0.003–0.74, p = 0.03).

Conclusion

Real-time CRO screening of donor lungs before transplantation at the point of care by the Xpert Carba-R helps clinicians formulate lung transplantation strategies quickly and reduces the risk of subsequent CRO infection improving the prognosis of lung transplantation.
Solving inverse problems for mixed-variational equations on perforated domains
Authors: Berenguer M. I. , Gámez D. , Garralda-Guillem A. I. , Kunze H. , La Torre D. , Ruiz Galán M.
Published: August 2023

The aim of this work is to analyze some conditions for the existence of solution of a perturbed mixed variational system and that of an associated inverse problem related to the collage-based approach, both on perforated domains or domains with holes. In addition, we study the influence of the size of the holes and state some convergence results. Finally, we conduct a computational study for solving some of those inverse problems.
Recent Advances in Structural Optimization and Surface Modification on Current Collectors for High-Performance Zinc Anode: Principles, Strategies, and Challenges
Authors: Gong Yuxin , Wang Bo , Ren Huaizheng , Li Deyu , Wang Dianlong , Liu Huakun , Dou Shixue
Published: August 2023

The last several years have witnessed the prosperous development of zinc-ion batteries (ZIBs), which are considered as a promising competitor of energy storage systems thanks to their low cost and high safety. However, the reversibility and availability of this system are blighted by problems such as uncontrollable dendritic growth, hydrogen evolution, and corrosion passivation on anode side. A functionally and structurally well-designed anode current collectors (CCs) is believed as a viable solution for those problems, with a lack of summarization according to its working mechanisms. Herein, this review focuses on the challenges of zinc anode and the mechanisms of modified anode CCs, which can be divided into zincophilic modification, structural design, and steering the preferred crystal facet orientation. The possible prospects and directions on zinc anode research and design are proposed at the end to hopefully promote the practical application of ZIBs.
Unmasking the Hypoxia Landscape in Cervical Cancer: S100A2 and Its Implication for Immunotherapy Resistance
Authors: Laban Mohamed , Chen Xi , Guo Bing
Published: August 2023

Cervical cancer is the fourth most common cancer in women worldwide and typically diagnosed between the ages of 35 and 44. Despite the death rate declining 1% each year since the 2000s, the 5-year survival of late stage remains lower than 20%. This emphasizes the urgency to keep exploring cervical cancer cell survival factors and identifying new prognostic markers. In this issue of Reproductive Sciences, Yang et al. stratified hypoxia subtype by analyzing 200 hypoxia-related genes in TCGA database and observed patient overall survival, hypoxic, transcriptome, genomics, and immunological characteristics vary among these hypoxia subtypes and created a hypoxia score which successfully stratified patient by predicting clinical outcomes and response to immunotherapy. Simultaneously, a hypoxia mediator (S100A2) associated with an aggressive cervical cancer phenotype is identified. We reviewed similar work on S100A2 and hypoxia-mediated multidrug resistance and highlighted the values added by this study. Future work could focus on unraveling the direct link between S100A2 and immunotherapy resistance.
Social media and ADHD: implications for clinical assessment and treatment
Authors: Hartnett Y. , Cummings E.
Published: August 2023

The interaction between social media use and mental health is complicated. The mental health information shared on these platforms is frequently of poor quality but has the potential to exert powerful influence on users. Social media trend peaks in some mental disorders have led to increases in illness behaviour through social contagion. There has been a marked upsurge in online interest in attention deficit hyperactivity disorder (ADHD) over the last number of years, which has been particularly noticeable since the onset of the COVID-19 pandemic. The exponential increase in online ADHD interest has the potential to contribute to overloading mental health services with referrals. Mental health professionals and organisations need to consider strategies to ensure that quality health information is disseminated to younger audiences.
Archaeological Analysis of a Water Mill from the Nineteenth Century in Salta, Argentina
Authors: Pifano Pablo José , Fernández Fernando J. , Guillermo Ailín A. , Petrucci Natalia S. , Páez María C.
Published: August 2023

Hydraulic mills were introduced in the early colonial period in the Americas to grind wheat into flour. During the nineteenth and twentieth centuries, the rise of the agro-export model in Latin America shaped the development of a flour industry in which water-powered mills played a central role. Over time, these technologies were used not only to increase production for the export market but also to meet the needs of domestic consumption, both local and regional. In this context, in 2017 we began to investigate the characteristics of a hydraulic mill, currently in disuse, in the town of Payogasta in the province of Salta (Argentina), to determine its chronology and functionality. In addition to surveying the structure, we conducted excavations in the nearby rooms that were part of the site. We found that this mill was in operation between the end of the nineteenth and the end of the twentieth centuries, grinding wheat, corn, carob, and red bell pepper, and that the adjoining rooms were used to house the people who were waiting their turn to grind their raw materials.
The Glorious Revolution and Access to Parliament
Authors: Dimitruk Kara
Published: August 2023

This paper shows that the Glorious Revolution of 1688 broadened access to Parliament for families needing rights to sell land in so-called estate bills. Bills were on average 14–27 percentage points more likely to be for gentry families and not aristocratic families in legislative sessions after the Revolution compared to sessions before. Regression and archival evidence suggest that parliamentary certainty was primarily responsible for improved access by altering families’ entry calculus and brokers’ recruitment of new business. More broadly, the paper provides insight into the ways in which political institutions affect access to and the provision of property rights.
Which English to teach?
Authors: Choe Hohsung , Lee Seongyong
Published: August 2023

The question of which English to teach has been an issue since the late-20th-century advent of the world Englishes (WE) paradigm. In the early 1990s, Quirk and Kachru conducted one of the most significant debates about this controversial issue in applied linguistics. Quirk (1990) argued that only standard native varieties that have no grammar deviations and adhere to mainstream vocabulary usage should be taught in order to counter the contamination of English resulting from tolerance of variations, observing that he was ‘not aware of there being any institutionalized nonnative varieties’ (p. 6). In contrast, Kachru (1991) argued that language variation due to language contact is a common sociolinguistic phenomenon, so Outer Circle varieties are not substandard or deficit languages. Therefore, he contended, traditional notions of standardization are no longer acceptable. He recommended that multiple localized varieties should be taught in Outer Circle contexts because they reflect learners’ linguistic and cultural identity. In relation to Kachru's argument, English as a lingua franca (ELF) has developed as a recent paradigm in TESOL. Kirkpatrick (2012) has argued that a lingua franca approach to English language teaching (ELT) helps prepare learners to use the language successfully in multilingual settings like ASEAN countries, where English functions as a lingua franca. In these settings, the teaching of ELF, in which speakers retain their own grammatical forms, phonological features, and pragmatic norms, needs to be promoted (Kirkpatrick 2011; Kirkpatrick, Subhan & Walkinshaw, 2016).
Habitat selection of southern giant petrels: potential environmental monitors of the Antarctic Peninsula
Authors: Finger Júlia Victória Grohmann , Krüger Lucas , Corá Denyelle Hennayra , Petry Maria Virginia
Published: August 2023

The southern giant petrel (Macronectes giganteus) is a widely distributed top predator of the Southern Ocean. To define the fine-scale foraging areas and habitat use of Antarctic breeding populations, 47 southern giant petrels from Nelson Island were GPS-tracked during the summers of 2019–2020 and 2021–2022. Step-selection analysis was applied to test the effects of environmental variables on habitat selection. Visual overlap with seal haul-out sites and fishing areas was also analysed. Birds primarily used waters to the south of the colony in the Weddell and Bellingshausen seas. Females showed a broader distribution, reaching up to -70°S to the west of Nelson Island, while males were mainly concentrated in waters off the northern Antarctic Peninsula. Habitat selection of both sexes was associated with water depth and proximity to penguin colonies. Both overlapped their foraging areas with fishing sites and females in particular overlapped with toothfish fishery blocks in Antarctica and with fishing areas in the Patagonian Shelf. Due to their habitat associations and overlap with fisheries, when harnessed with tracking devices and animal-borne cameras, giant petrels can act as platforms for monitoring the condition and occurrence of penguin colonies, haul-out sites and unregulated fisheries on various temporal and spatial scales in Antarctica.
Eocene to Oligocene cooling and ice growth based on the geochemistry of interglacial mudstones from the East Antarctic continental shelf
Authors: Light Jennifer J. , Passchier Sandra
Published: August 2023

The Eocene-Oligocene Transition at c. 34 million years ago (Ma) marked the global change from greenhouse to icehouse and the establishment of the East Antarctic Ice Sheet (EAIS). How the ice-sheet behaviour changed during interglacials across this climate transition is poorly understood. We analysed major, trace and rare earth elemental data of late Eocene interglacial mudstone from Prydz Bay at Ocean Drilling Program Site 1166 and early Oligocene interglacial mudstone from Integrated Ocean Drilling Program Site U1360 on the Wilkes Land continental shelf. Both sites have comparable glaciomarine depositional settings. Lithofacies and provenance at Site 1166 in Prydz Bay are indicative of a late Eocene glacial retreat in the Lambert Graben. Palaeoclimate proxies, including the Chemical Index of Alteration, mean annual temperature and mean annual precipitation, show a dominant warm and humid palaeoclimate for the late Eocene interglacial. In contrast, at Site U1360, in the early Oligocene, the provenance and interglacial weathering regime remained relatively stable with conditions of physical weathering. These results confirm that the EAIS substantially retreated periodically during late Eocene interglacials and that subglacial basins probably remained partially glaciated during interglacials in the earliest Oligocene.
Knowing “what for,” but not “where”: Dissociation between functional and contextual tool knowledge in healthy individuals and patients with dementia
Authors: Baumard Josselin , Lesourd Mathieu , Jarry Christophe , Merck Catherine , Etcharry-Bouyx Frédérique , Chauviré Valérie , Belliard Serge , Osiurak François , Le Gall Didier
Published: August 2023

Objective:

Semantic tool knowledge underlies the ability to perform activities of daily living. Models of apraxia have emphasized the role of functional knowledge about the action performed with tools (e.g., a hammer and a mallet allow a “hammering” action), and contextual knowledge informing individuals about where to find tools in the social space (e.g., a hammer and a mallet can be found in a workshop). The goal of this study was to test whether contextual or functional knowledge, would be central in the organization of tool knowledge. It was assumed that contextual knowledge would be more salient than functional knowledge for healthy controls and that patients with dementia would show impaired contextual knowledge.

Methods:

We created an original, open-ended categorization task with ambiguity, in which the same familiar tools could be matched on either contextual or functional criteria.

Results:

In our findings, healthy controls prioritized a contextual, over a functional criterion. Patients with dementia had normal visual categorization skills (as demonstrated by an original picture categorization task), yet they made less contextual, but more functional associations than healthy controls.

Conclusion:

The findings support a dissociation between functional knowledge (“what for”) on the one hand, and contextual knowledge (“where”) on the other hand. While functional knowledge may be distributed across semantic and action-related factors, contextual knowledge may actually be the name of higher-order social norms applied to tool knowledge. These findings may encourage researchers to test both functional and contextual knowledge to diagnose semantic deficits and to use open-ended categorization tests.
Performance of Lightning Potential Index, Lightning Threat Index, and the Product of CAPE and Precipitation in the WRF Model
Authors: Saleh Narges , Gharaylou Maryam , Farahani Majid M. , Alizadeh Omid
Published: August 2023

Lightning is a naturally occurring phenomenon with significant socioeconomic and environmental impacts, underlining the need for the application of advanced methods to predict it. This study aims to evaluate the performance of the Weather Research and Forecasting (WRF) model in the prediction of the lightning potential index (LPI), the lightning threat index (LTI), and the product of convective available potential energy (CAPE) and precipitation (CAPE × P). Based on the intensity of convection and the number of lightning flashes, we simulated seven thundercloud events that occurred in Tehran between 2008 and 2013. The simulated LPI, LTI, and CAPE × P values are compared both qualitatively and quantitatively against ground‐based lighting data obtained from the world wide lightning location network (WWLLN). LPI, LTI, and CAPE × P predict the location of lightning with relatively good accuracy, although LPI outperforms LTI and CAPE × P. We also compared the simulated area‐averaged LPI, LTI, and CAPE × P against the number of lightning flashes from the WWLLN data, based on which LPI shows a better performance. Overall, LPI can be used as an effective index for the prediction of lightning. As LPI is based on cloud microphysics and LTI and CAPE × P are thermodynamic‐based methods, a better performance of LPI implies that a method based on the microphysical approach can better predict lightning. The performance of LPI, LTI, and CAPE × P is also sensitive to the horizontal resolution of model simulations, with a considerable improvement in simulations with higher horizontal resolutions.
Identifying Temperature and Moisture Controls on Fe Oxide Origins
Authors: Lepre Christopher
Published: August 2023

Magnetism, redness, and Fe oxides are indicators of pedoclimatic conditions. However, uncertainties with observing how Fe oxides form within soils has led to debates about relationships between magnetic mineral assemblages, temperature, and rainfall. To address these issues, Fe oxides from the equatorial tropics of Kenya were examined in Pliocene soils that developed under orbital forcing of the monsoon. Results demonstrate that with warm‐wet monsoons, ferrimagnetic production was increased and correlated with hematite concentrations, in accordance with expectations that ferrimagnetic and hematite minerals codevelop from amorphous Fe oxides. With cool‐dry monsoons, hematite concentrations increased but ferrimagnetic production decreased and decoupled from hematite development. These findings suggest that decreased rainfall rather than temperature change favored the dehydration step required to catalyze hematite enrichment within soils. This study explains Fe oxides origins under variable monsoonal climates and recognizes moisture changes in comparison to temperature as stronger controls on the production of soil‐formed hematite.
Seismic Imaging Beneath Cascadia Shows Shallow Mantle Flow Patterns Guide Lower Mantle Upwellings
Authors: Dai Yuhang , Rychert Catherine A. , Harmon Nicholas
Published: August 2023

The mantle transition zone (MTZ) plays an important role in modulating material transport between the upper mantle and the lower mantle. Constraining this transport is essential for understanding geochemical reservoirs, hydration cycles, and the evolution of the Earth. Slabs and hotspots are assumed to be the dominant locations of transport. However, the degree of material transport in other areas is debated. We apply P‐to‐S receiver functions to an amphibious data set from Cascadia to image the MTZ discontinuities beneath mid‐ocean ridges, a hotspot, and a subduction zone. We find a MTZ thinned by 10 ± 6 km beneath the ridges and by 8 ± 4 km beneath the base of the slab, closely resembling the 660 discontinuity topography. Depressions on the 410 discontinuity are smaller, 5 ± 2 km on average, focused in the north and the south and accompanied by supra‐410 discontinuity melt phases. The depressions occur away from locations of uplifted 660 discontinuity, but near slow seismic velocity anomalies imaged in the upper mantle. This suggests lower mantle upwellings occur beneath ridges and beneath the base of slabs but stall in the transition zone, with upper mantle convection determining upward material transport from the transition zone. Therefore, upper mantle dynamics play a larger role in determining transfer than typically assumed.
A Generalized Area‐Based Framework to Quantify River Mobility From Remotely Sensed Imagery
Authors: Greenberg Evan , Chadwick Austin J. , Ganti Vamsi
Published: August 2023

Rivers are the primary conduits of water and sediment across Earth's surface. In recent decades, rivers have been increasingly impacted by climate change and human activities. The availability of global‐coverage satellite imagery provides a powerful avenue to study river mobility and quantify the impacts of these perturbations on global river behavior. However, we lack remote sensing methods for quantifying river mobility that can be generally applied across the diversity of river planforms (e.g., meandering, braided) and fluvial processes (e.g., channel migration, avulsion). Here, we upscale area‐based methods from laboratory flume experiments to build a generalized remote sensing framework for quantifying river mobility. The framework utilizes binary channel‐mask time series to determine time‐ and area‐integrated rates and scales of river floodplain reworking and channel‐thread reorganization. We apply the framework to numerical models to demonstrate that these rates and scales are sensitive to specific river processes (channel migration, channel‐bend cut‐off, and avulsion). We then apply the framework to natural migrating and avulsing rivers with meandering and braided planforms. Results show that our area‐based framework provides an objective and accurate means to quantify river mobility at reach‐ to floodplain‐scales, which is largely insensitive to spatial and temporal biases that can arise in traditional mobility metrics. Our work provides a framework for investigating global controls on river mobility, testing hypotheses about river response to environmental gradients, and quantifying the timescales of terrestrial organic carbon cycling.
Vibrational circular dichroism unveils hidden clues
Authors: Nguyen Dang Du , Kim Inki
Published: August 2023

Infrared chiral plasmonic metamaterials based on perpendicularly positioned nanorods enable surface-enhanced vibrational circular dichroism for more selective and sensitive identification of protein fingerprints and enantioselective sensing, which creates a new pathway for chemical or biomedical applications.
Military-related mild traumatic brain injury: clinical characteristics, advanced neuroimaging, and molecular mechanisms
Authors: Kim Sharon Y. , Yeh Ping-Hong , Ollinger John M. , Morris Herman D. , Hood Maureen N. , Ho Vincent B. , Choi Kwang H.
Published: August 2023

Mild traumatic brain injury (mTBI) is a significant health burden among military service members. Although mTBI was once considered relatively benign compared to more severe TBIs, a growing body of evidence has demonstrated the devastating neurological consequences of mTBI, including chronic post-concussion symptoms and deficits in cognition, memory, sleep, vision, and hearing. The discovery of reliable biomarkers for mTBI has been challenging due to under-reporting and heterogeneity of military-related mTBI, unpredictability of pathological changes, and delay of post-injury clinical evaluations. Moreover, compared to more severe TBI, mTBI is especially difficult to diagnose due to the lack of overt clinical neuroimaging findings. Yet, advanced neuroimaging techniques using magnetic resonance imaging (MRI) hold promise in detecting microstructural aberrations following mTBI. Using different pulse sequences, MRI enables the evaluation of different tissue characteristics without risks associated with ionizing radiation inherent to other imaging modalities, such as X-ray-based studies or computerized tomography (CT). Accordingly, considering the high morbidity of mTBI in military populations, debilitating post-injury symptoms, and lack of robust neuroimaging biomarkers, this review (1) summarizes the nature and mechanisms of mTBI in military settings, (2) describes clinical characteristics of military-related mTBI and associated comorbidities, such as post-traumatic stress disorder (PTSD), (3) highlights advanced neuroimaging techniques used to study mTBI and the molecular mechanisms that can be inferred, and (4) discusses emerging frontiers in advanced neuroimaging for mTBI. We encourage multi-modal approaches combining neuropsychiatric, blood-based, and genetic data as well as the discovery and employment of new imaging techniques with big data analytics that enable accurate detection of post-injury pathologic aberrations related to tissue microstructure, glymphatic function, and neurodegeneration. Ultimately, this review provides a foundational overview of military-related mTBI and advanced neuroimaging techniques that merit further study for mTBI diagnosis, prognosis, and treatment monitoring.
Targeted inhibition of eIF5Ahpu suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer
Authors: Zeng Jincheng , Ye Ziyu , Shi Shihong , Liang Yanfang , Meng Qingyu , Zhang Qunzhou , Le Anh D.
Published: August 2023

Eukaryotic initiation factor 5A2 (eIF5A2) is overexpressed in many types of cancer, and spermidine-mediated eIF5A hypusination (eIF5Ahpu) appears to be essential to most of eIF5A’s biological functions, including its important role in regulating cancer cell proliferation, epithelial–mesenchymal transition (EMT), and cancer stem cell (CSC) properties as well as immune cell functions. Here we investigated the role of eIF5Ahpu in the growth of oral squamous cell carcinoma cells (OSCCs) and OSCC-induced polarization of M2-like tumor-associated macrophages (TAMs). TCGA dataset analysis revealed an overall upregulation in the mRNA expression of eIF5A2 and several key enzymes involved in polyamine (PA) metabolism in HNSCC, which was confirmed by Western blot and IHC studies. Blocking eIF5Ahpu by GC-7 but not the upstream key enzyme activities of PA metabolism, remarkably inhibited cell proliferation and the expression of EMT- and CSC-related genes in OSCC cells. In addition, blocking eIF5Ahpu robustly inhibited OSCC-induced M2-like TAM polarization in vitro. More Importantly, blocking eIF5Ahpu dramatically retarded tumor growth and infiltration/polarization of M2-like TAM in a syngeneic orthotopic murine tongue SCC model. Thus, eIF5Ahpu plays dual functions in regulating tumor cell growth and polarization of M2-TAMs in OSCC.
Identifying s-wave pairing symmetry in single-layer FeSe from topologically trivial edge states
Authors: Wei Zhongxu , Qin Shengshan , Ding Cui , Wu Xianxin , Hu Jiangping , Sun Yu-Jie , Wang Lili , Xue Qi-Kun
Published: August 2023

Determining the pairing symmetry of single-layer FeSe on SrTiO3 is the key to understanding the enhanced pairing mechanism. It also guides the search for superconductors with high transition temperatures. Despite considerable efforts, it remains controversial whether the symmetry is the sign-preserving s- or the sign-changing s±-wave. Here, we investigate the pairing symmetry of single-layer FeSe from a topological point of view. Using low-temperature scanning tunneling microscopy/spectroscopy, we systematically characterize the superconducting states at edges and corners of single-layer FeSe. The tunneling spectra collected at edges and corners show a full energy gap and a substantial dip, respectively, suggesting the absence of topologically non-trivial edge and corner modes. According to our theoretical calculations, these spectroscopic features can be considered as strong evidence for the sign-preserving s-wave pairing in single-layer FeSe.
Early-stage bifurcation of crystallization in a sphere
Authors: Mbah Chrameh Fru , Wang Junwei , Englisch Silvan , Bommineni Praveen , Varela-Rosales Nydia Roxana , Spiecker Erdmann , Vogel Nicolas , Engel Michael
Published: August 2023

Bifurcations in kinetic pathways decide the evolution of a system. An example is crystallization, in which the thermodynamically stable polymorph may not form due to kinetic hindrance. Here, we use confined self-assembly to investigate the interplay of thermodynamics and kinetics in the crystallization pathways of finite clusters. We report the observation of decahedral clusters from colloidal particles in emulsion droplets and show that these decahedral clusters can be thermodynamically stable, just like icosahedral clusters. Our hard sphere simulations reveal how the development of the early nucleus shape passes through a bifurcation that decides the cluster symmetry. A geometric argument explains why decahedral clusters are kinetically hindered and why icosahedral clusters can be dominant even if they are not in the thermodynamic ground state.
Heterogeneous changes of soil microclimate in high mountains and glacier forelands
Authors: Marta Silvio , Zimmer Anaïs , Caccianiga Marco , Gobbi Mauro , Ambrosini Roberto , Azzoni Roberto Sergio , Gili Fabrizio , Pittino Francesca , Thuiller Wilfried , Provenzale Antonello , Ficetola Gentile Francesco
Published: August 2023

Landscapes nearby glaciers are disproportionally affected by climate change, but we lack detailed information on microclimate variations that can modulate the impacts of global warming on proglacial ecosystems and their biodiversity. Here, we use near-subsurface soil temperatures in 175 stations from polar, equatorial and alpine glacier forelands to generate high-resolution temperature reconstructions, assess spatial variability in microclimate change from 2001 to 2020, and estimate whether microclimate heterogeneity might buffer the severity of warming trends. Temporal changes in microclimate are tightly linked to broad-scale conditions, but the rate of local warming shows great spatial heterogeneity, with faster warming nearby glaciers and during the warm season, and an extension of the snow-free season. Still, most of the fine-scale spatial variability of microclimate is one-to-ten times larger than the temporal change experienced during the past 20 years, indicating the potential for microclimate to buffer climate change, possibly allowing organisms to withstand, at least temporarily, the effects of warming.
Charged biexciton polaritons sustaining strong nonlinearity in 2D semiconductor-based nanocavities
Authors: Wei Ke , Liu Qirui , Tang Yuxiang , Ye Yingqian , Xu Zhongjie , Jiang Tian
Published: August 2023

Controlling the interaction between light and matter at micro- and nano-scale can provide new opportunities for modern optics and optoelectronics. An archetypical example is polariton, a half-light-half-matter quasi particle inheriting simultaneously the robust coherence of light and the strong interaction of matter, which plays an important role in many exotic phenomena. Here, we open up a new kind of cooperative coupling between plasmon and different excitonic complexes in WS2-silver nanocavities, namely plasmon-exciton-trion-charged biexciton four coupling states. Thanks to the large Bohr radius of up to 5 nm, the charged biexciton polariton exhibits strong saturation nonlinearity, ~30 times higher than the neutral exciton polariton. Transient absorption dynamics further reveal the ultrafast many-body interaction nature, with a timescale of <100 fs. The demonstration of biexciton polariton here combines high nonlinearity, simple processing and strong scalability, permitting access for future energy-efficient optical switching and information processing.
Arctic soil methane sink increases with drier conditions and higher ecosystem respiration
Authors: Voigt Carolina , Virkkala Anna-Maria , Hould Gosselin Gabriel , Bennett Kathryn A. , Black T. Andrew , Detto Matteo , Chevrier-Dion Charles , Guggenberger Georg , Hashmi Wasi , Kohl Lukas , Kou Dan , Marquis Charlotte , Marsh Philip , Marushchak Maija E. , Nesic Zoran , Nykänen Hannu , Saarela Taija , Sauheitl Leopold , Walker Branden , Weiss Niels , Wilcox Evan J. , Sonnentag Oliver
Published: August 2023

Arctic wetlands are known methane (CH4) emitters but recent studies suggest that the Arctic CH4 sink strength may be underestimated. Here we explore the capacity of well-drained Arctic soils to consume atmospheric CH4 using >40,000 hourly flux observations and spatially distributed flux measurements from 4 sites and 14 surface types. While consumption of atmospheric CH4 occurred at all sites at rates of 0.092 ± 0.011 mgCH4 m−2 h−1 (mean ± s.e.), CH4 uptake displayed distinct diel and seasonal patterns reflecting ecosystem respiration. Combining in situ flux data with laboratory investigations and a machine learning approach, we find biotic drivers to be highly important. Soil moisture outweighed temperature as an abiotic control and higher CH4 uptake was linked to increased availability of labile carbon. Our findings imply that soil drying and enhanced nutrient supply will promote CH4 uptake by Arctic soils, providing a negative feedback to global climate change.
Imaging brain tissue architecture across millimeter to nanometer scales
Authors: Michalska Julia M. , Lyudchik Julia , Velicky Philipp , Štefaničková Hana , Watson Jake F. , Cenameri Alban , Sommer Christoph , Amberg Nicole , Venturino Alessandro , Roessler Karl , Czech Thomas , Höftberger Romana , Siegert Sandra , Novarino Gaia , Jonas Peter , Danzl Johann G.
Published: August 2023

Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease.
Activity-based profiling of cullin–RING E3 networks by conformation-specific probes
Authors: Henneberg Lukas T. , Singh Jaspal , Duda David M. , Baek Kheewoong , Yanishevski David , Murray Peter J. , Mann Matthias , Sidhu Sachdev S. , Schulman Brenda A.
Published: August 2023

The cullin–RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that switch from inactive to activated conformations upon site-specific cullin modification by the ubiquitin-like protein NEDD8. Assessing cellular repertoires of activated CRL complexes is critical for understanding eukaryotic regulation. However, probes surveying networks controlled by site-specific ubiquitin-like protein modifications are lacking. We developed a synthetic antibody recognizing the active conformation of NEDD8-linked cullins. Implementing the probe to profile cellular networks of activated CUL1-, CUL2-, CUL3- and CUL4-containing E3s revealed the complexes responding to stimuli. Profiling several cell types showed their baseline neddylated CRL repertoires vary, and prime efficiency of targeted protein degradation. Our probe also unveiled differential rewiring of CRL networks across distinct primary cell activation pathways. Thus, conformation-specific probes can permit nonenzymatic activity-based profiling across a system of numerous multiprotein complexes, which in the case of neddylated CRLs reveals widespread regulation and could facilitate the development of degrader drugs.
DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging
Authors: Hosogane Tsuyoshi , Casanova Ruben , Bodenmiller Bernd
Published: August 2023

Imaging mass cytometry (IMC) is a highly multiplexed, antibody-based imaging method that captures heterogeneous spatial protein expression patterns at subcellular resolution. Here we report the extension of IMC to low-abundance markers through incorporation of the DNA-based signal amplification by exchange reaction, immuno-SABER. We applied SABER-IMC to image the tumor immune microenvironment in human melanoma by simultaneous imaging of 18 markers with immuno-SABER and 20 markers without amplification. SABER-IMC enabled the identification of immune cell phenotypic markers, such as T cell co-receptors and their ligands, that are not detectable with IMC.
Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2
Authors: Gangwar Shanti Pal , Yen Laura Y. , Yelshanskaya Maria V. , Korman Aryeh , Jones Drew R. , Sobolevsky Alexander I.
Published: August 2023

Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and can be targeted to treat neuropsychiatric and neurological disorders, including epilepsy. Here we present cryogenic-electron microscopy structures of rat GluA2 AMPAR complexes with inhibitory mouse γ5 and potentiating human cornichon-2 (CNIH2) auxiliary subunits. CNIH2 appears to destabilize the desensitized state of the complex by reducing the separation of the upper lobes in ligand-binding domain dimers. At the same time, CNIH2 stabilizes binding of polyamine spermidine to the selectivity filter of the closed ion channel. Nevertheless, CNIH2, and to a lesser extent γ5, attenuate polyamine block of the open channel and reduce the potency of the antiepileptic drug perampanel that inhibits the synaptic complex allosterically by binding to sites in the ion channel extracellular collar. These findings illustrate the fine-tuning of synaptic complex structure and function in an auxiliary subunit-dependent manner, which is critical for the study of brain region-specific neurotransmission and design of therapeutics for disease treatment.