bluuebunny/crossref_metadata_2025 huggingface dataset:
Coregistration of multimodal imaging is associated with favourable two‐year seizure outcome after paediatric epilepsy surgery
Authors: Perry Michael Scott , Bailey Laurie , Freedman Daniel , Donahue David , Malik Saleem , Head Hayden , Keator Cynthia , Hernandez Angel
Published: August 2019

Aims. Multimodal coregistration uses multiple image datasets coregistered to an anatomical reference (i.e. MRI), allowing multiple studies to be viewed together. Commonly used in intractable epilepsy evaluation and generally accepted to improve localization of the epileptogenic zone, data showing that coregistration improves outcome is lacking. We compared seizure freedom following epilepsy surgery in paediatric patients, evaluated before and after the use of coregistration protocols at our centre, to determine whether this correlated with a change in outcome.

Methods. We included paediatric epilepsy surgery patients with at least one anatomical and one functional neuroimaging study as part of their presurgical evaluation. Preoperatively designated palliative procedures and repeat surgeries were excluded. Multiple pre‐, peri‐, and postoperative variables were compared between groups with the primary outcome of seizure freedom.

Results. In total, 115 were included with an average age of 10.63 years (0.12–20.7). All evaluations included video‐EEG (VEEG) and MRI. Seven (6%) had subtraction single‐photon emission CT (SPECT), 46 (40%) had positron emission tomography (PET), and 62 (54%) had both as part of their evaluation. Sixty (52%) had extratemporal epilepsy and 25 (22%) were MRI‐negative. Sixty‐eight (59%) had coregistration. Coregistered patients were less likely to undergo invasive EEG monitoring (p=0.045) and were more likely to have seizure freedom at one (p=0.034) and two years (p<0.001) post‐operatively. A logistic regression accounting for multiple covariates supported an association between the use of coregistration and favourable post‐surgical outcome.

Conclusions. Coregistered imaging contributes to favourable postoperative seizure reduction compared to visual analysis of individual modalities. Imaging coregistration is associated with improved outcome, independent of other variables after surgery. Coregistered imaging may reduce the need for invasive EEG monitoring, likely due to improved confidence in presurgical localization. These findings support the use of multimodal coregistered imaging as part of the presurgical assessment in patients evaluated for surgical treatment of intractable epilepsy.
Intractable ictal vomiting: a new form of reflex epilepsy?
Authors: Sureshbabu Sachin , Nayak Dinesh , Aggarwal Vikash , Peter Sudhir , Khanna Laxmi , Mittal Gaurav
Published: August 2019

In this description of the clinical course of a young female with persistent and protracted vomiting along with occasional loss of consciousness and subtle motor manifestations, the differential diagnosis is debated. The epileptic origin of her symptoms was substantiated by the presence of interictal epileptiform discharges and dramatic response to valproate monotherapy. Possible lobar localizations are discussed with the support of existing literature on this rare ictal manifestation [Published with video sequence on www.epilepticdisorders.com].
A case of post‐leptospirosis autoimmune epilepsy presenting with sleep‐related hypermotor seizures
Authors: Makhija Prashant , Gopinath Siby , Kannoth Sudheeran , Radhakrishnan Kurupath
Published: August 2019

This video‐illustrated case report concerns a 49‐year‐old woman who presented with sleep‐related hypermotor seizures. The antecedent history of leptospirosis, high frequency of new‐onset seizures, presence of an unclassified anti‐neuronal antibody, and dramatic response to steroids strongly supported post‐infectious immune‐mediated pathogenesis in our patient. To the best of our knowledge, post‐leptospirosis autoimmune epilepsy presenting as sleep‐related hypermotor seizures has not hitherto been reported. [Published with video sequence on www.epilepticdisorders.com].
Mowat‐Wilson syndrome presenting with fever‐associated seizures
Authors: Seo Se Eun , Kim Se Hee , Lee Seung Tae , Choi Jong Rak , Lee Joon Soo , Kim Heung Dong , Kang Hoon‐Chul
Published: August 2019

Mowat‐Wilson syndrome (MWS) is a disorder caused by mutations or deletions of the zinc finger E‐box‐binding homeobox 2 (ZEB2) gene. Diagnosis of MWS can be challenging to neurologists, because its manifestations are diverse and the spectrum of genetic mutations are broad. Here, we describe two patients with MWS who initially showed atypical forms of fever‐triggered seizures during childhood. Both had characteristic facial features, cognitive impairment, and genito‐urinary anomalies consistent with MWS. By performing targeted next‐generation sequencing (NGS) using a gene panel for epilepsy, we were able to identify a nonsense mutation (c.1965C>A) in the ZEB2 gene of one patient and a frameshift mutation (c.2348dupC) in the other patient. Fever‐induced seizures can be presenting signs of MWS. MWS should be considered in the differential diagnosis of fever‐induced seizures, especially when the patient has distinctive facial features and multiple anomalies, including cardiac, genito‐urinary, and eye defects.
Early infancy‐onset stimulation‐induced myoclonic seizures in three siblings with inherited glycosylphosphatidylinositol (GPI) anchor deficiency
Authors: Mogami Yukiko , Suzuki Yasuhiro , Murakami Yoshiko , Ikeda Tae , Kimura Sadami , Yanagihara Keiko , Okamoto Nobuhiko , Kinoshita Taroh
Published: August 2019

Inherited glycosylphosphatidylinositol anchor deficiency causes a variety of clinical symptoms, including epilepsy, however, little information is available regarding seizures as a symptom. We report three siblings with inherited glycosylphosphatidylinositol anchor deficiency with PIGL gene mutations. The phenotypes of the subjects were not consistent with CHIME syndrome or Mabry syndrome, as reported in previous studies. All shared some clinical manifestations, including transient apnoea as neonates, dysmorphic facial features, and intellectual disability. Between one week and 3 months of life, all patients developed myoclonic seizures. Myoclonic jerks were easily evoked by sudden unexpected acoustic or tactile stimuli. None showed elevation of serum alkaline phosphatase. Vitamin B6 was given to one of the three siblings, but failed to suppress seizures. The presence of early infancy‐onset stimulation‐induced myoclonic seizures combined with dysmorphic facial features should lead physicians to consider the possibility of inherited glycosylphosphatidylinositol anchor deficiency.
Long‐term seizure outcome following epilepsy surgery in the parietal lobe: a meta‐analysis
Authors: Pilipović‐Dragović Sanja , Ristić Aleksandar J. , Bukumirić Zoran , Trajković Goran , Sokić Dragoslav
Published: August 2019

Aim. Due to a limited number of patients with drug‐resistant parietal lobe epilepsy in surgical series, there are insufficient data about long‐term seizure outcome following surgery restricted to the parietal lobe. We performed a meta‐analysis to asses long‐term outcomes in patients with parietal lobe epilepsy who underwent surgery confined to the parietal lobe or resection with major involvement of the parietal cortex.

Methods. An English language literature search for studies on parietal lobe surgery and outcome was conducted using the MEDLINE database, followed by a manual search based on specific criteria. An inverse variance random effect meta‐analysis model was used to estimate the pooled proportion of Engel Class I. Meta‐regression models were used to examine the association between outcome and potential predictors.

Results. The search yielded seven retrospective studies with a total sample size of 253 patients (mean follow‐up: 104.9±74.8 months). Following surgery, Engel Class I surgical outcome was achieved in 62.4% (95% CI: 0.492–0.755). Two independent predictors were identified for positive long‐term outcome: interictal EEG localized to the parietal region (p=0.007) and the presence of tumour (p=0.022).

Conclusion. Following surgery confined to the parietal lobe or resection with major involvement of the parietal cortex, the long‐term prognosis of patients with parietal lobe epilepsy is favourable.
A child with hyperekplexia and epileptic myoclonus
Authors: Wadi Lara , Medlej Yasser , Obeid Makram
Published: August 2019

Hyperekplexia is a rare neurogenetic disorder characterized by startle. Accurate diagnosis of this notorious mimicker of epilepsy is important to prevent life‐threatening apnoea. We report a novel case of concomitant GLRA1‐related hyperkeplexia and myoclonic epilepsy. A toddler with daily paroxysms of head drops and falls presented with epileptic myoclonus on EEG, however, whole‐exome sequencing revealed hyperekplexia‐related GLRA1 mutation. The boy eventually developed spells induced by noise and surprise. All his spells remitted upon treatment with clonazepam. Paediatricians and paediatric neurologists should be aware of this possible mixed presentation in order to appropriately tailor medication regimens and treatment goals. [Published with video sequence on www.epilepticdisorders.com].
Neonatal tremor episodes and hyperekplexia‐like presentation at onset in a child with SCN8A developmental and epileptic encephalopathy
Authors: Pons Linda , Lesca Gaëtan , Sanlaville Damien , Chatron Nicolas , Labalme Audrey , Manel Véronique , Arzimanoglou Alexis , de Bellescize Julitta , Lion‐François Laurence
Published: August 2019

SCN8A encephalopathy is a newly defined epileptic encephalopathy caused by de novo mutations of the SCN8A gene. We report herein a four‐year‐old boy presenting with severe non‐epileptic abnormal movements, of possibly antenatal onset, progressively associated with pharmacoresistant epilepsy and regression, associated with a de novo heterozygous missense mutation of SCN8A. This case shows that paroxysmal non‐epileptic episodes of severe tremor and hyperekplexia‐like startles and a striking vegetative component can be the first early symptoms of severe SCN8A developmental and epileptic encephalopathy. Clinicians should be aware of these symptoms in order to avoid misdiagnosis and ensure early appropriate therapeutic management. [Published with video sequences on www.epilepticdisorders.com].
Identifying the educational needs of physicians in pediatric epilepsy in order to improve care: results from a needs assessment in Germany, Spain, and the United States
Authors: Murray Suzanne , Labbé Sara , Kothare Sanjeev , Málaga Ignacio , Kluger Gerhard , Ogden Patti , Lazure Patrice , Arzimanoglou Alexis
Published: August 2019

Aims. The objective of this study was to gather evidence‐based data on the educational needs of neuropediatricians. A needs assessment was conducted to identify the clinical challenges of physicians when diagnosing, medically treating, and managing pediatric patients with epilepsy; which could be addressed through educational interventions.

Methods. A two‐phase mixed‐methods approach was used to conduct the needs assessment in Germany, Spain, and the US. Phase 1 consisted of qualitative data collection through multiple sources: a literature review, semi‐structured interviews with clinicians and nurses working in pediatric epilepsy, and interpretation and input from faculty experts. Qualitative data were coded (NVivo) and analyzed using a thematic analysis, and findings were then used to design the second phase. Phase 2 consisted of quantitative data collection through an online survey that aimed to validate the identified challenges and underlying causes using a larger sample than in Phase 1. Data from the survey were analyzed using frequency tabulations and chi‐square tests (SPSS).

Results. A total of 267 participants were included in the study. Phase 1 included 88 participants (neurologists, pediatricians, neuropediatricians, and nurses). Phase 2 included 179 participants (neurologists, pediatricians, and neuropediatricians). The main areas of challenge which emerged from the triangulated data included: the integration of guidelines into practice, identification of epilepsy and epilepsy events, integration of genetic testing into practice, integration of non‐pharmacological treatments, transition from pediatric to adult care, and involvement and engagement with caregivers. Underlying causes of these challenges are reported, along with supporting qualitative findings.

Conclusions. This study identified the educational needs of physicians working in pediatric epilepsy in Germany, Spain and the USA. Increasingly, educational interventions are required to be evidence‐based. The results of this study could be used to design such interventions to support neuropediatricians who wish to specialize in pediatric epileptology, in order to manage the identified challenges.
A web‐based diagnostic reference centre for the European Reference Network “EpiCare”: recommendations of the eNeuropathology working group
Authors: Kölble Konrad , Cross J. Helen , Becker Albert , Blümcke Ingmar
Published: August 2019

Epilepsy surgery is a valuable treatment strategy for a selected group of patients with drug‐resistant focal epilepsy. While reliable disease classification is essential for the optimal management of patients in general and crucial for the development of more personalized therapies in the future, arriving at a precise diagnosis often poses considerable difficulties due to the broad and variant‐rich spectrum of epilepsy‐associated brain lesions. Given the scarcity of European institutions diagnostically focusing on the histopathology of epilepsy surgery cases, the provision of subspecialty expertise as well as training opportunities remains logistically and financially challenging. To improve this situation, the European Reference Network's (ERN) epilepsy care program (EpiCare, http://epi-care.eu) has set out to develop a web‐based microscopy referral and teaching framework. This paper reviews the aspects of digital microscopy, data storage, and image analysis technology relevant to the practice of neuropathology. Cognizant of the European data security requirements and regulations, we propose a collaborative, diagnostic network initiative (the eNeuropathology reference centre) and delineate a roadmap for its implementation favouring open‐source, vendor‐independent browser platforms.
De novo absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?
Authors: Caraballo Roberto H. , Chacón Santiago , Fasulo Lorena , Bedoya Claudio
Published: August 2019

Aim. Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive.

Methods. We describe the electroclinical features, treatment, and evolution of three paediatric patients with de novo ASE with an excellent response to valproic acid (VPA).

Results. Three paediatric patients presented with non‐convulsive status epilepticus and an acute confusional state with impaired consciousness and EEG abnormalities compatible with typical ASE, associated with generalized spike‐and‐wave paroxysms at 2.5‐4 Hz, as the first epileptic manifestation at eight, three, and nine years of age, respectively. No significant personal and/or family history was reported. None of the patients had absence seizures or any other type of seizure before the occurrence of the ASE. All of them responded well to VPA and had a benign disease course. Neuroradiological imaging was normal in all patients. These three cases presented with ASE as the first manifestation of their epilepsy; none of them had any other type of seizure before the event or during their follow‐up, which was long‐term in one. All patients had an excellent response to VPA.

Conclusions. Our three cases presented with generalized typical ASE as the first manifestation of their epilepsy. De novo ASE might be considered as a well‐defined idiopathic epilepsy syndrome or a variant of an idiopathic generalized epilepsy syndrome, such as a particular type or variant of childhood absence epilepsy.
Araştırma Sorgulamaya Dayalı Öğretimin Ortaokul Öğrencilerinin Fen Başarısı, Sorgulama Algısı ve Üstbiliş Farkındalığına Etkisi
Authors: VARLI Burcu , SAĞIR Şafak Uluçınar
Published: August 2019

Bu çalışmanın amacı, ilköğretim fen bilimleri dersinde 5. sınıf
"Işığın ve Sesin Yayılması" ünitesinde araştırma sorgulamaya dayalı
öğrenme yaklaşımının, öğrencilerin akademik başarı, üstbiliş ve sorgulama
becerisi algıları üzerine etkisini araştırmaktır. Çalışmada, ön test- son test
kontrol gruplu yarı deneysel desen kullanılmıştır. Araştırmanın örneklemini
2016-2017 eğitim öğretim yılında, Samsun ili Havza ilçesinde bulunan bir
ortaokulda öğrenim gören 31 öğrenci oluşturmaktadır. Uygulama kapsamında,
araştırma sorgulamaya dayalı öğrenme yaklaşımına uygun etkinlikler
geliştirilmiştir. Çalışmada veri toplama aracı olarak; başarı testi,
Sorgulayıcı Öğrenme Becerileri Algısı ölçeği ve Üstbiliş ölçeği kullanılmıştır.
Deney grubunda araştırma sorgulamaya dayalı öğretim yaklaşımı uygulanırken
kontrol grubunda daha önceden sınıfta uygulanan yöntemle konunun öğretimi
yapılmıştır.Çalışmanın analizinde SPSS 20.0 istatistik paket programı
kullanılmıştır. Verilerin normal dağılımı, çarpıklık-basıklık değerlerinden ve
Kolmogorov Smirnov testi ile kontrol edilmiştir. Normal dağılım gösteren
verilere parametrik testler uygulanmıştır. t-testi ve ANCOVA varsayımlarının
kontrolü yapılmış ve bu testlerin uygulaması uygun bulunmuştur. Sonuçlar p=0.05
anlamlılık düzeyinde değerlendirilmiştir. Araştırmada,araştırma sorgulamaya
dayalı öğrenme yaklaşımının; öğrencilerin akademik başarıları, sorgulayıcı
öğrenme becerileri ve üstbilişleri üzerinde anlamlı etkisi olduğu sonucuna
ulaşılmıştır. Araştırmacılara yönelik çeşitli önerilerde bulunulmuştur.
İngilizce Konuşma Kaygısı Ölçeği’nin Türkçeye Uyarlanma Çalışması
Authors: ALKAN Hale , T. BÜMEN Nilay , USLU Öner
Published: August 2019

Bu çalışmanın amacı Woodrow’un (2006)
geliştirdiği (İkinci Dil) İngilizce Konuşma Kaygısı Ölçeği’ni Türkçeye
uyarlamaktır. Ölçeğin dilsel eşdeğerliği için, Ege Üniversitesi Yabancı Diller
Yüksek Okulu’nda orta düzeyde İngilizce öğrenmekte olan bir öğrenci grubuna
(n=54) 15 gün ara ile İngilizce ve Türkçe form çevrimiçi olarak uygulanmıştır.
Bu uygulamada pozitif ve anlamlı bir ilişki elde edilmiş (.882, p<.01),
Türkçe form aynı üniversitede farklı düzeylerde İngilizce öğrenen 778 öğrenciye
uygulanarak açımlayıcı faktör analizi yapılmış, toplam varyansın %64.14’ünü
açıklayan iki faktörlü bir yapı elde edilmiştir. Ölçeğin ölçüt bağıntılı geçerliği
için yapılan korelasyon analizleri sonucunda anlamlı ilişkiler saptanmıştır.
Doğrulayıcı faktör analizi yapmak üzere aynı okulda orta düzeyde İngilizce
öğrenen farklı bir gruba (n=455) ölçek yeniden uygulanmıştır. Orijinal ölçeğin
iki faktörlü yapısı doğrulanmış, elde edilen uyum indekslerinin mükemmel uyum
sınırları içerisinde olduğu görülmüştür. Bu çalışmadaki ölçümlere ilişkin
güvenirlik katsayıları sınıf içinde konuşma kaygısı boyutunda .83, sınıf
dışında ise .85 olarak hesaplanmıştır. Yapılan analiz sonuçları, ölçeğin
Türkiye’de kullanılabileceğini göstermektedir.
PARADIGM OF INTER-HOUSE PARTNERSHIP IN THE MODERN QUANTUM WORLD: THE INTERNATIONAL SECURITY SECTOR
Authors: Lisovsky P.M. , Lisovska Yu. P.
Published: August 2019

The article considers the modern transitional model of inter-agency partnership as a qualitatively new semantic state of person, state and society, in which the international security sector plays an important role. On the basis of the analysis, a new transient model of inter-agency partnership in the modern quantum world has been outlined that includes a set of original (natural, authentic, exclusive, etc.) phenomen, in which the quantum is the minimum unit of any physical object that has corpuscular-wave universe structure in the modern geopolitics of states. At the same time, the quantum world is a collection of original phenomen, investigated by a phenomenal approach. The author's vision regarding the innovative updating of the content of anti-corruption education on the European level is revealed. No less strategic direction of interdepartmental partnership is cyber justice - the introduction of new practices from both the developers of new technologies and users of such technologies, which collectively provide the quality of services provided by the courts. The conceptual model of quantum philosophy as an entropy matrix in interdepartmental partnership is highlighted. The investment policy of states in the quantum world is outlined. It has been argued that the state border guard is the key to success in the international legal field of interdepartmental partnership characterized by a qualitatively new semantic state of the individual, state and society, in which the international security sector plays an important role. It is alleged that security sector reform in the inter-agency partnership of the world contributes to the qualitative growth of the scientific and technological potential as a breakthrough in the future. Under current circumstances, anti-corruption education is an important criterion in the international security sector as an intellectual critical infrastructure of inter-agency partnership. It is proved that the innovative updating of the content of education at the European level today should be the aggregate fundamental matrix of interagency, providing the corresponding quality on the basis of prestige, competitiveness and perspective needs of the individual, state and society. The filling of interdepartmental partnership with specific content takes place depending on the specific goals and tasks that are solved by it.
CONFLICTOGENIC POTENTIAL OF ASYMMETRIC CHINESE-VIETNAM RELATIONS
Authors: Derevianko I. P.
Published: August 2019

The article analyzes the features of Sino-Vietnamese asymmetric relations with a powerful destructive potential. The focus is on the elements of the confrontation between China and Vietnam, which prevent the acceleration and expansion of the scope of strategic cooperation. It has been found that bilateral relations between China and Vietnam, although they are developing in the format of "comprehensive strategic cooperation and partnership", did not avoid a confrontation caused by territorial disputes in the South China Sea. Vietnam is experiencing serious discomfort from the strengthening of China’s aggressive regional policy, acquiring a systemic and clearly structured character. The key configurations and trajectories of Vietnam’s basic strategies aimed at containing China, which is trying to gradually reformat the space around it is borders, are explored. It has been established that Sino-Vietnamese relations are a combination of political, ideological and cultural contacts with a complex of contradictions. Despite the weakening of the role of ideological tenets, the Communist Parties of China and Vietnam are too close and control the most important vectors of development of bilateral relations. It was noted that despite the intensification of contradictions, Sino-Vietnamese relations are dynamically developing and evolving and their cooperation to a certain extent is based on the search for compromises, common points of contact between positions and mutually acceptable solutions.
Effect of bromfenac on free radical oxidation in model systems
Authors: Galimova E F , Khaibullina Z G , Enikeev D A , Bortsova Yu L , Mochalov K S , Galimova S Sh , Travnikov O Yu , Asadullina T S , Aver’yanova K S
Published: August 2019

Aim. The study of free radical oxidation processes in an experiment on model systems using the anti-inflammatory drug bromfenac (nakwan) widely used in ophthalmology for the treatment of infectious and inflammatory diseases of the anterior chamber of the eye.

Methods. The antioxidant capacity of the drug was evaluated by chemiluminescence registration and analysis of model systems that generate reactive oxygen species and reproduce lipid peroxidation processes using the chemiluminomer CL-003. The following parameters of spontaneous and induced chemiluminescence were determined: light sum and maximum luminescence amplitude, duration of latent period, amplitude of fast and slow flash.

Results. When tested in vitro in two different model systems, a high antioxidant activity of the studied drug was established, up to complete suppression of chemiluminescence when 90 μg of bromfenac was added to the incubation medium, which characterizes the inhibition of the generation of reactive oxygen species. A significant increase in total antioxidant activity with bromfenac was also demonstrated, which is reflected by the integral parameter of chemiluminescence — light sum which decreased with the introduction of 10 μg of the drug by 1.2 times, and with 90 μg by 1.5 times. A comparative analysis of the antioxidant properties of various nonsteroidal anti-inflammatory drugs used in ophthalmic practice demonstrated a more pronounced efficacy of bromfenac compared to ketorolac, the use of which was not accompanied by statistically significant changes in chemiluminescence. A very important mechanism of the positive effect of bromfenac is the direct dependence of the action on its quantity in the reaction medium, which opens up prospects for the controlled correction of free radical phenomena and the excessive activation of lipid peroxidation in the imbalance of the pro- and antioxidant processes in biological systems.

Conclusion. It is suggested that the protective effects of the drug in various infectious-inflammatory lesions of the eye can be determined, along with previously known properties, its antioxidant activity, restriction of increased production of reactive oxygen species and oxidative stress phenomena.
Capabilities of cytostatic agents usage in ophthalmology
Authors: Belousova N Yu , Poltanova T I
Published: August 2019

Antineoplastic drugs are increasingly used in the treatment of diseases of the vision organ. However, practicing ophthalmologists often deal with lack of information about the choice of drugs with anticancer effect, their mechanism of action, dosage, route of administration, potential side effects including their prevention. Mechanism of action is presented for the most commonly used immunosuppressants in ophthalmology (such as metabolic antagonists, alkylation agents, antineoplastic antibiotics, monoclonal antibodies). Efficiency and routes of administration are described for cytostatics used for the treatment of intraocular tumors (retinoblastoma), for prevention and treatment of proliferative syndrome in ophthalmosurgery complicating the surgery for glaucoma, pterigium and refractive corneal procedures, and presenting the pathogenetic basis of proliferative vitreoretinopathy and posterior lens capsule opacity. Possible local side effects of immunosupressors in ocular surgery are presented (epithelial and suture defects, hemorrhagic choroidal detachment, cataract progression, endophthalmitis, malignant glaucoma, toxic effect on the ciliary body, keratopathy, hypertensive maculopathy). Also, the issue of the use of cytostatics and immunodepressants for acute and chronic inflammatory eye diseases is discussed (for example, for uveitis, filamentary ke­ratitis, allergic blepharoconjunctivitis, allergic conjunctivitis and spring ophthalmia, adenoviral keratoconjunctivitis, rosacea keratitis, ocular pemphigoid, recurrent chalazion, scleritis, episcleritis, painful bullous keratopathy, state after keratoplasty and refractive surgery of ocular fibrous capsule). Special attention was paid to the eye neovascularization and common use of intravitreal injections of monoclonal antibodies (ranibizumab, aflibercept) for premature infants’ retinopathy, choroidal neovascularization of various origin (in trauma, myopia, histoplasmosis), neovascular form of age-related macular dystrophy, secondary neovascular glaucoma, proliferative diabetic retinopathy and diabetic macular edema. Need for search of new more effective and safe medicines with antineoplastic and immunodepressive action is emphasized for ophthalmology, eye surgery and medicine in general.
O tratamento dos estrangeirismos nas duas últimas edições do Dicionário da Língua Portuguesa, da Porto Editora
Authors: Rebollo de Andrade Ana , Lavouras Lopes António
Published: August 2019

O tratamento dos estrangeirismos nas duas últimas edições do Dicionário da Língua Portuguesa, da Porto Editora.
Algunas consideraciones sobre diccionarios bilingües españoles
Authors: Sánchez Merino Antonio
Published: August 2019

Algunas consideraciones sobre diccionarios bilingües españoles.
Los diccionarios escolares a comienzos del siglo XXI
Authors: Sánchez Muñoz Trinidad
Published: August 2019

Los diccionarios escolares a comienzos del siglo XXI.
José-Álvaro Porto Dapena (2002): Manual de técnica lexicográfica. Madrid, Arco/Libros
Authors: Campos Souto Mar
Published: August 2019

Reseña de libro: José-Álvaro Porto Dapena (2002): Manual de técnica lexicográfica. Madrid, Arco/Libros.
Huellas ideológicas en la lexicografía cubana
Authors: Camacho Barreiro Aurora M.
Published: August 2019

Huellas ideológicas en la lexicografía cubana.
Las denominaciones del cáñamo: un problema terminológico y lexicográfico
Authors: Díaz Rojo José Antonio
Published: August 2019

Las denominaciones del cáñamo: un problema terminológico y lexicográfico.
La lexicografía bilingüe en la actualidad y su valoración
Authors: Haensch Günther
Published: August 2019

La lexicografía bilingüe en la actualidad y su valoración.
Ignacio Ahumada Lara, ed. (2001): Cinco Siglos de Lexicografía del Español, IV Seminario de Lexicografía Hispánica, Jaén, 17 al 19 de noviembre de 1999, Jaén, Universidad de Jaén, 441 pp.
Authors: Salas Quesada Pilar
Published: August 2019

Reseña de libro: Ignacio Ahumada Lara, ed. (2001): Cinco Siglos de Lexicografía del Español, IV Seminario de Lexicografía Hispánica, Jaén, 17 al 19 de noviembre de 1999, Jaén, Universidad de Jaén, 441 pp.
Seco, Manuel (2003): Estudios de lexicografía española, Madrid, Gredos, 2.ª edición aumentada y revisada
Authors: Vivanco Cervero Verónica
Published: August 2019

Reseña de libro: Seco, Manuel (2003): Estudios de lexicografía española, Madrid, Gredos, 2.ª edición aumentada y revisada.
Judit Freixa y Elisabet Solé (coords.) (2004): Llengua catalana i neologia, Barcelona, Meteora
Authors: García Palacios Joaquín
Published: August 2019

Reseña de libro: Judit Freixa y Elisabet Solé (coords.) (2004): Llengua catalana i neologia, Barcelona, Meteora.
La Resolución 1325: Mujeres, Paz y Seguridad en las Operaciones de Mantenimiento de la Paz
Authors: Sepúlveda Soto Daniela , Rivas-Pardo Pablo
Published: August 2019

Este artículo analiza la incorporación de la Resolución 1325 del Consejo de Seguridad de Naciones Unidas y sus Resoluciones Complementarias -las que conforman la Agenda Mujeres, Paz y Seguridad- en las Resoluciones que crearon las Operaciones de Mantenimiento de la Paz desde el año 2000 en adelante, que justamente son creadas por el mismo Organismo. Teóricamente, se proponen tres estadios de análisis: la mujer como sujeto de protección, la mujer como sujeto de pacificación y la promoción de la perspectiva de género, basándose en el contenido de la Agenda Mujeres, Paz y Seguridad. Tales estadios se aplican en las Resoluciones seleccionadas por medio de un análisis de texto. Las conclusiones evidencian falencias en la incorporación de la Resolución 1325 y sus Resoluciones Complementarias, instrumentos promovidos desde el propio Consejo de Seguridad de Naciones Unidas, junto con mostrar la existencia de una variabilidad en la forma como se incorporaron estos estadios de análisis en la selección de casos.
LÍNEA JURISPRUDENCIAL DEL CONSEJO DE ESTADO SOBRE LOS TÍTULOS DE IMPUTACIÓN PARA ATRIBUIR RESPONSABILIDAD MÉDICA
Authors: ESTRADA ESPAÑA KARELLYS NORAINE
Published: August 2019

Este artículo construye la línea jurisprudencial de la  Sección Tercera del Consejo  de Estado en materia de títulos de imputación para atribuir responsabilidad médica estatal en Colombia, en el periodo comprendido entre el año 1991 y el año 2016. En el proyecto se identifican los cambios en los títulos de imputación, se describen las tesis planteadas y se determinan los puntos de ruptura entre las tesis. En este caso, se inicia con el análisis concreto de las sentencias proferidas por esa Alta Corporación, hasta llegar a la generalización de las tesis y los puntos de ruptura encontrados en el desarrollo del tema. Concluido el estudio, se encontró que el título de imputación para atribuir responsabilidad médica estatal durante ese periodo de tiempo, fue el de la falla en el servicio, bajo tres modalidades o tesis distintas: falla del servicio probada, falla presunta del servicio y las cargas dinámicas de la prueba. Igualmente, se halló  que los cambios de tesis dentro del título de imputación de falla del servicio, surgieron de las reglas probatorias que se utilizaron para demostrar la responsabilidad de la Entidad Estatal; y que los puntos de ruptura entre las distintas tesis, están relacionados de manera general, con las desigualdades de las partes que en su momento advirtió el Alto Tribunal, frente a las reglas probatorias utilizadas para imputar responsabilidad médica.
Primary modular straight stem cemented prosthetic replacement for unstable, comminuted intertrochanteric fracture in the elderly with severe osteoporosis
Authors: Pillai Manju G.
Published: August 2019

Background: The increasing number of hip fractures in the elderly, with the subset of unstable, comminuted intertrochanteric hip fractures is extremely relevant as the treatment is hampered by unsuccessful fixations and high complication rates. Osteoporosis and fracture geometry are two factors responsible for the failure of fixation in such fractures, upon which the surgeon has no control. Hence newer methods of fixation or treatment have to be opted for. The objective of the study was to evaluate the functional outcome of primary modular cemented prosthetic replacement for unstable, osteoporotic intertrochanteric fractures in a selected group of patients.

Methods: A total of 34 patients with type II and type III unstable intertrochanteric fractures were treated with primary modular cemented bipolar prosthesis and followed up in Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla.

Results: After surgery 94.12% patients regained walking capacity. The functional outcome at the time of discharge was fair to excellent in 88.24% of cases. The complications were few and the major benefit was early ambulation of patients and return to pre-fracture level of activity.

Conclusions: Primary modular bipolar straight stem cemented prosthetic replacement is probably the best option for treatment in previously independently ambulant, elderly osteoporotic patients with unstable, comminuted intertrochanteric fracture of femur.
TERRITÓRIOS DA CIDADANIA CATARINENSES: ANÁLISE DOS INDICADORES DE DESENVOLVIMENTO SUSTENTÁVEL
Authors: Jubanski Jociane Aparecida , Knorek Reinaldo , Pedrassani Daniela
Published: August 2019

A dinâmica de funcionamento da sociedade pós-industrial impõe um estilo de vida insustentável para o meio ambiente, conduzindo a grandes dívidas relacionadas a questões ecológicas, sociais, econômicas e culturais. Estas questões estão intimamente interligadas no processo de desenvolvimento sustentável. Assim, este artigo tem em seu escopo discussões sobre desenvolvimento sustentável e os programas de desenvolvimento territorial sustentável, em especial, o Programa Territórios da Cidadania. O objetivo da pesquisa foi analisar os indicadores de desenvolvimento sustentável nos Territórios da Cidadania Catarinenses. Para tal foi desenvolvida uma pesquisa aplicada, quantitativa, bibliográfica e documental. Quanto ao método de cálculo foi aplicada a interpolação linear simples e para análise de dados foi utilizado o método barômetro da sustentabilidade. Os resultados indicaram que os níveis de sustentabilidade dos dois territórios foram similares. O Território da Cidadania do Planalto Norte (TCPN) e o Território da Cidadania do Meio Oeste Contestado (TCMOC) foram classificados como nível intermediário para os subsistemas social, econômico e ambiental, nível insustentável para o subsistema institucional, índice de bem-estar humano potencialmente sustentável e; índice de bem-estar ecológico potencialmente insustentável. Conclui-se que nos Territórios da Cidadania Catarinenses, o fenômeno desenvolvimento está caminhando a passos lentos para sustentabilidade e, que os indicadores de desenvolvimento sustentável forneceram uma visão geral de que nesses territórios o crescimento, o progresso e consequentemente o desenvolvimento sustentável ocorrem de maneira lenta e insatisfatória.
Interleukin-13, Interleukin-10, Interferon-gamma and IDO Production in Response to Home Dust Mites in Allergic Asthma
Authors: Kwarta Cityta Putri , Wibowo Heri , Khaedir Yordan , Rengganis Iris , Nuraeni Hanny Siti
Published: August 2019

BACKGROUND: Allergic asthma is a degenerative atopic disease caused by allergic or hypersensitivity type-1. More than 50% of people with allergic asthma are caused by the presence of house dust mites (HDMs) allergens.METHODS: The cellular immunity response was evaluated through a peripheral blood mononuclear cell (PBMC) culture isolated from blood, using the ficoll gradient technique. Subjects were atopic asthma groups and non-atopic asthma groups. PBMC from each subject cultured was stimulated with HDMs allergen, then incubated in a CO2 5% incubator, 37o C for 72 hours. With the multiplex assay method, interferon (IFN)-γ, interleukin (IL)-13 and IL-10 were measured, meanwhile indoleamine 2,3-dioxygenase level (IDO) was measured by the enzyme-linked immunosorbent assay (ELISA) sandwich methods.RESULTS: The IFN-γ production in the supernatant of PBMC cultures was stimulated by phytohemagglutinin (PHA), Roswell Park Memorial Institute (RPMI) medium and allergens. The IFN-γ production in allergen-stimulated supernatants showed higher level of IFN-γ in the nonatopic group (4,681,455±3,434,851) than atopic group (4,363,300±2,067,941) even though it was not statistically significant (p=0.078). There were no differences between the mean of IL-13 production in atopic asthma group and non-atopic group. The IL-10 production in allergenstimulated supernatants was shown to be higher in nonatopic group and were statistically significantly different (p=0.015). The IDO production in allergen-stimulated supernatants was shown to be higher in the non-atopic group (272,231±269,564) than in the actopic group (13,273±400), and it was significantly different (p=0.007).CONCLUSION: Cellular immune profile of subjects with allergic asthma to Dermatophagoides pterronyssinus (Der p) is characterized by a type-2 inflammatory response that is dominant compared to type-1 inflammation (higher IL-13 ratio compared to IFN-γ) and to the role of anti-inflammation (higher IL-13 ratio compared to IL-10). The decline in IDO production in allergic asthma subjects to Der p is thought to be related to the low cellular immune response in expressing IFN-γ compared to IL-13.KEYWORDS: interleukin-13, interleukin-10, IDO, PBMC, asthma
Yes! Kissing Too… The Child Would Not Be Hurt in Any Way: Social Constructions of Child Sexual Abuse in the Ga Community in Ghana
Authors: Markwei Ummu
Published: August 2019

The United Nations Convention on the Rights of the Child obligates nations to protect children from all forms of abuse including sexual. However, child sexual abuse is a complex phenomenon which is difficult to understand as a result of cultural reasons. In view of this, the programs, policies, and interventions put in place to curb the phenomenon of child sexual abuse globally can only be effective if they are relevant to the social and cultural setting within which it happens. This is an exploratory study that sought to investigate social constructions of child sexual abuse in the Ga community. The study uses qualitative research methods to collect data from 42 respondents via six focus group discussions across three selected towns in the Greater Accra Region of Ghana. The findings showed that sexual activities between adults and children that were regarded as acceptable did not constitute child sexual abuse. However, sexual behaviors between adults and children that were regarded as unacceptable were viewed as serious, hence, considered as sexual abuse. The findings of this study illustrate the need for appropriate cultural interventions in curbing the phenomenon of child sexual abuse in the Ga Community in Ghana.
Religion and Culture of Origin. Re-Shaping Identity in the Integration Process: A Case Study in Sicily
Authors: Ferrante Lorenzo
Published: August 2019

What happens when people of different cultures, values, religion live together? Sociological studies on immigrative phenomenon often swing between immigration and integration policies. These policies actually reveal the difficulty of the host society to institutionalize new models of social differences accompanying multiculturalism. Immigrants who “arrive” continue their life in a place where they do not passively participate in the passing of time, but become actors. Pressed by the hegemonic culture of the host society to adapt, do not cease to practice their religious and origin cultural expressions, often in conditions of urban spatial and social marginalization, they resist assimilation with ethnic persistence strategies. Considering the impact of religion and origin cultural values on expression of differences, it is important to consider their role in the integration process. And, above all—facilitate or hinder integration? These dynamics have been analyzed in a research study on immigrants’ integration process in Palermo. The main results are presented in this paper. In this case study, the research’s data hypothesizes a theoretical model of integration in which immigrants, free to express their religious and cultural differences, tend to reduce their perception of minority
Judicial Practice in Distribution of Inheritance (mīrāth) in Islamic Courts in Nigeria
Authors: Ismael Ismael Saka , Oba Abdulmumini Adebayo
Published: August 2019

Inheritance is one of the issues that has attracted the attention of many Islamic jurists. Although it has been regulated in fiqh books, the distribution of inheritance has the potential to cause disputes. This paper examines the legal framework governing distribution of inheritance under Islamic law as interpreted in Islamic courts in Nigeria. The paper analyses decided cases in constructing the judicial practice in distribution of estates among heirs in Islamic courts in Nigeria from commencement to conclusion of such distributions. This research is a legal normative study using judicial case and conceptual approaches. The paper concludes that Islamic courts in Nigeria adhere strictly to the Maliki school in the matters concerning distribution of inheritance.
ORVEL 1984
Authors: Csányi Erzsébet Ferenc , Ottó Beke , János Samu
Published: August 2019

Digitalne diktature koje opisuje Juval Noa Harari karakteriše totalna vlast, centralizovana obrada podataka i informisanje koje se izvodi u (računalnom) tehničkom okruženju. Roman Džordž Orvela 1984 je književna prefiguracija tog totalitarnog društvenog sistema. Instrumenti masovne medije, metode opservacije i instrukcije opisane u tekstu tehnički su definisane, funkcionišu kao pretekst digitalizacije, a simbolični Veliki brat ilustruje centralizovanu prirodu kontrole i upravljanja u dijegetskom svetu romana. Metoda tumačenja razrađena u studiji ne zanemaruje ni estetske vrednosti teksta, njegove književne karakteristike, žanrovske korene i njegov paradigmatičan značaj, a pritom osvjetljava razloge savremene i sve veće popularnosti romana, referencijalnog statusa, i objašnjava zašto njegovi simboli postaju samostalni i šire se virulentno u različitim domenima i diskursima umetnosti i kulture.
Implementasi Wakaf Produktif Dalam Perspektif Ekonomi Syariah
Authors: Purnomo Agus , Khakim Lutfi
Published: August 2019

Wakat produktif menjadi salah satu sumber daya yang harus dikelola dengan baik. Pengelolaan wakaf produktif terkait dengan faktor pengembangan dan penyaluran hasil pengelolaan wakaf. Penelitian ini bertujuan untuk mengetahui Wakaf Produktif Pada Yayasan Bina Insan Madani Banjarmasin. Metode penelitian ini menggunakan deskriptif kualitatif. Jenis penelitian ini adalah penelitian lapangan (field Research), yaitu melakukan penelitian tentang wakaf produktif dalam perspektif hukum ekonomi syariah di Yayasan Bina Insan Madani Banjarmasin. Hasil penelitian: (a) Implementasi pengelolaan wakaf produktif secara umum telah dilakukan dengan baik sesuai dengan aturan yang berlaku oleh pengurus yayasan Bina Insan Madani Banjarmasin disesuaikan dengan kebutuhan peruntukannya sudah memenuhi empat Rukun wakaf dan syaratnya, walaupun demikian, wakaf tersebut ada yang diberikan langsung maupun tidak langsung kepada pengurus yayasan. (b) Konsep pelaksanaan wakaf produktif di Yayasan Bina Insan Madani Banjarmasin sudah sesuai perspektif ekonomi syariah dengan tidak adanya penimbunan barang (Ihtikar), tidak melakukan monopoli, juga tidak melakukan jual beli yang diharamkan agama dengan menggunakan harta/aset wakaf. Wakaf produktif yang dimiliki yayasan dipergunakan untuk pembangunan sarana dan kegiatan ibadah, pembangunan sarana pendidikan, belum digunakan untuk bantuan kepada fakir miskin, anak terlantar, santunan yatim piatu dan peningkatan ekonomi dan kesejateraan masyarakat.(Productive Endowments becomes one of the resources that must be managed properly. The management of productive endowments is related to the factors of development and distribution of Endowments management results. This research uses descriptive qualitative method. This type of research is a field research, which is conducting research on productive endowments in the perspective of sharia economic law in Yayasan Bina Insan Madani Banjarmasin. The research results are: (a) Generally, the implementation of productive endowments management has been done well in accordance with the rules applicable by the admnistrators of Bina Insan Madani Foundation Banjarmasin and it is suited to the needs of its allocation which should be fulfilled the four pillars of productive endowments and its terms, however, the productive endowments is either given directly or indirectly to the foundation board. (b) The concept of the implementation of productive endowments in Bina Insan Madani Foundation Banjarmasin is in accordance with the Shariah economic perspective in the absence of stockpiling, not monopolizing, nor doing the forbidden trading by Islam using productive endowments assets. Productive endowments owned by Yayasan are used to build some religious facilities and activities and the construction of educational facilities. It is also used for helping the poor, homeless children, orphans and the improvement of the economy and welfare of the community.)