bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultural Dynamics Shaping the Adoption of Modern Management, Green Innovation, and Digitization in Uzbekistan's Business Landscape
Authors: Ogunmola Gabriel Ayodeji
Published: January 2025

Since the gain of independence in 1991, Uzbekistan has worked through diverse economic transformations with a transition from a central economy to a Market economy. These have sought to develop entrepreneurship and encourage FDI inflows, at the same time business is still shaped by history, culture and institutions. For this investigation, the affect of the cultural dimensions including collectivism, power distance, and long term orientation towards the adoption of modern management practices, green innovation and digitization in Uzbekistan is examined. Hofstede’s Cultural Dimensions Theory, Theory of Planned Behavior, and the Technology-Organization-Environment are used to analyze these influences in the present research. The study shows that collectivism positively influences the implementation of the modern management practices while high power distance negatively influence it. Long-term orientation to a very large extent influences green innovation and appropriate attitude toward technology is essential for digitalization. Subjective norms which are highly endorsed scale and perceived behavioral control further enhance green innovation and digitization respectively. Furthermore, other adoption conditions such as the technological and environmental support for the adoptions are important while size and centralization of organizations present adoption challenges. Thus, this work enriches the scientific literature by revealing the dependencies of business activities in a transitional economy with respect to cultural values. The conclusions for business and authorities stress the importance of cultural contingency approach to improve organization performance and improvement in Uzbekistan. The future research should incorporate longitudinal studies and pay attention to such other cultural dimensions and characteristics of organizations.
Highlights:

Uzbekistan transitions from central to market economy, shaping business by culture.
Collectivism aids modern management; power distance hinders; long-term orientation boosts innovation.
Cultural values, technology, and environment critical for green innovation, digitization success.

Keywords: Cultural dimensions, Hofstede's Cultural Dimensions Theory, Theory of Planned Behavior, Technology-Organization-Environment framework, sustainability
Digital Supervision for Critical Awareness and Ethical Technology Integration in Education
Authors: Fitrotul Choiriyah  , Nashrullah Mochamad , Nursalim Mochamad , Amrozi Khamidi
Published: January 2025

General Background: The digital era has transformed education, enhancing access, efficiency, and learning personalization through technology. Specific Background: In Indonesia, the COVID-19 pandemic accelerated technological adoption in education supervision, crucial for improving teaching quality despite challenges like limited infrastructure, digital literacy, and resistance to change. Knowledge Gap: Limited research addresses how digital supervision integrates critical awareness to evaluate the ethical, social, and pedagogical impacts of technology. Aims: This study explores how digital education supervision enhances teacher professionalism, critical awareness, and effective technology use in learning. Results: Digital supervision, utilizing tools like Learning Management Systems (LMS) and e-supervision platforms, enables real-time teacher monitoring, reflective dialogue, and data-driven feedback while fostering educators' ability to assess technology's pedagogical value and ethical implications. Novelty: It introduces a philosophical framework—ontology, epistemology, and axiology—to position digital supervision as both a practical tool and transformative agent, addressing gaps in digital literacy and infrastructure inclusivity. Implications: The findings advocate for comprehensive policies, digital literacy training, and collaborative strategies, ensuring supervision effectively integrates critical awareness and technology efficiency to drive sustainable, inclusive educational transformation.
Highlights:

Digital supervision enhances real-time monitoring, reflective dialogue, and data-driven feedback.
Integrating critical awareness ensures ethical and pedagogical use of technology in education.
A philosophical framework—ontology, epistemology, and axiology—supports inclusive supervision strategies.

Keywords: Digital Education Supervision, Critical Awareness, Technology Effectiveness, Digital Literacy, Teacher Professionalism Development
Prevalence of Pediculosis in Some Primary Schools in Diyala Province, Iraq
Authors: Abed Noora Dhyaaldain
Published: January 2025

Background:Pediculosis (human head lice) infestation is aglobal problem among primary schools.Aims: This study has been conducted to investigate the prevalence of head lice among some primary schools in Diyala province. Methodology and Results: The study samples were randomly collected from the city center and villages, during the period from October/2022 to February/2023. This study examined 1579 pupils to detect pediculosis. The results have revealed 234 infections among the school students which represents 14.819% of the total examined sample. The infections among females were higher than males (217) females were infected which represents 92.735% of the total infections. Moreover, the study found that the proportion of pediculosis in rural areas was higher than in urban,60.256% and 39.743% respectively. The study has also shown the highest rate of infection among females in ages 10-14 years 39.316%, compared with other groups, Moreover, the study has shown the relationship between the mother’s education level and pediculosis. The percentage of infection among students who have mothers without university degrees was 83.333% while those who have mothers with university degrees were 16.666%. The study has also pointed to the significant effect of family size on infection percentages. A high percentage was recognized among those who live in big families,66.239%. Conclusion, significance, and impact of study: Infection is prevalent among pupils, and risk factors play an important role in this situation which requires that controlling the infection and treating infected pupils be given the utmost importance to increase awareness.
Highlights:

Prevalence: 14.8% of students infected, higher in females and rural areas.
Risk Factors: Low maternal education and large family size increase infection.
Action: Control measures and awareness programs are urgently needed.

Keywords: Pediculosis, Head lice, Nits, Pediculus humanus capitis
Impacto de un sistema web para mejorar el proceso de ventas en la empresa Cuerosinka, 2024
Authors:   , Monzon Villa Carlos Eduardo
Published: January 2025

La presente investigación tiene un enfoque de analizar en que si un sistema web genera un impacto en el proceso de ventas a la empresa CUEROSINKA, se tiene como objetivo mejorar los tiempos de ventas que viene manejando esta empresa, apoyándose de un sistema tecnológico para automatizar el proceso de ventas donde teniendo en cuenta que muchas empresas hoy en día vienen implementando herramientas sistemáticas para disminuir costos e incrementar ingresos eso hace que los clientes se sienten satisfechos en hacer sus comprar de la manera más sencilla y fácil con lo que conlleva a que las empresas sean competitivas en el mercado empresarial. Según (Quispe Chalco, 2022), A raíz de la pandemia muchos comercios decidieron implementar sistemas electrónicos o E-Commerce para mejorar o actualizar los diferentes modelos de negocios de las compañías, esto con el fin de automatizar y agilizar los procesos. En ese sentido conexión a través de internet genera mayor satisfacción de interacción entre el cliente y la empresa.
Estabilidad de color de distintos tonos de un cemento resinoso fotopolimerizable sometido a una bebida en el tiempo. Estudio in vitro
Authors:   , Cortez Koo Lorel Sullin
Published: January 2025

Objetivo: El objetivo de este estudio es evaluar la estabilidad de color de los diferentes tonos de un cemento resinoso fotopolimerizable sometido a una bebida en el tiempo. Método: Se fabricaron 36 discos de cemento resinoso fotopolimerizable (Variolink Esthetic LC) con un diámetro de 10x1mm,divididos en tres grupos (n=12) de acuerdo al tono de cemento (light, neutral y warm).La mitad de las muestras fueron sumergidas en agua destilada y otra mitad en un medio de tinción durante 15 min para después almacenarse en agua destilada durante un periodo de 28 días, las evaluaciones se realizaron en un intervalo de tiempo de 7,14,21 y 28 días mediante un espectrofotómetro. La diferencia de color se calculó utilizando la formula CIELAB después de cada intervalo de tiempo. Los datos se analizaron estadísticamente utilizando la prueba de ANOVA junto con la prueba post-hoc de Tukey para comparaciones múltiples (p<0.05). Resultado: Todos los resultados obtuvieron una diferencia significativa, sin embargo, la mayor variación en la estabilidad del color de los cementos resinosos se encontró en los discos sumergidos en café; de los cuales, los tonos más claros (Light y Neutral) fueron los que presentaron mayores cambios (p<0.001). Conclusión: La estabilidad de color se vio influenciada por el tono de cemento y por el tipo de bebida en el tiempo, el tono light y neutral presento mayor variación en estabilidad de color al ser sumergido en café y en agua el tono neutral presento una mayor variación de color.
Percepción de la actividad física en pacientes con diabetes mellitus tipo 2 en Lima, Perú
Authors:   , Vargas Soriano Silvia Maribel , Sulca Aquino Mariela
Published: January 2025

La diabetes mellitus (DM) tipo 2 es una enfermedad crónica que involucra cambios metabólicos producidos principalmente por la resistencia a la insulina y el agotamiento progresivo de las células beta que causan deficiencias en la secreción de insulina, siendo parte de la terapéutica la ejecución de actividad física frecuente por parte del paciente. Objetivo: Determinar la percepción de la actividad física en los pacientes con diabetes mellitus tipo 2. Materiales y métodos: Estudio de tipo observacional, analítico y de corte transversal aplicado sobre una muestra constituida por 210 pacientes de género femenino y masculino, tomando el Cuestionario de Actividad Física para Pacientes Diabéticos (PAQ-DP) como instrumento de recolección de datos. Resultados: El género masculino predominó con el 51.43% (n = 108). Asimismo, el promedio del puntaje en el cuestionario de actividad física para pacientes diabéticos fue de 74.94 con una desviación estándar de 14.40. Se evidenció una asociación significativa entre las subescalas actitud afectiva y edad, actitud afectiva y antecedentes de sobrepeso y autoidentidad y antecedentes de sobrepeso. Conclusión: Las percepciones sobre la actividad física en pacientes con diabetes mellitus tipo 2 fueron positivas, existiendo correlación entre determinadas subescalas del instrumento de recolección de datos, la edad y los antecedentes de sobrepeso.
The optimal temperature of ecosystem respiration homogenizes under global warming
Authors: Niu Shuli , Zheng Qinyu , Wang Song , Chen Weinan , Li Tao , Liáng Lìyǐn , Chu Houkun , Wang Yiheng
Published: January 2025

Terrestrial ecosystem respiration (ER) is a key component of the carbon cycle and is highly temperature sensitive. While ER has often been modeled as an exponential function of temperature, recent evidence shows that ER exhibits an optimal temperature (Topt) and a monotonic response beyond this threshold. However, the temporal dynamics of Topt under climate warming remain poorly understood. This study analyzed data from 135 long-term FLUXNET sites, each with at least five years of observation. Our results show that Topt of ER increased with rising temperatures, indicating thermal acclimation, with a global average acclimation magnitude (Topt change per unit change in maximum temperature across years within the site) of 0.82°C. More interestingly, this acclimation magnitude showed a negative correlation with mean annual temperature. This negative correlation suggests that ecosystems in colder regions exhibit higher acclimation magnitudes compared to warmer regions, potentially reducing the variation in Topt across biomes under future warming. These findings indicate a homogenization of Topt under warming conditions. Our scenario analysis suggested that neglecting thermal acclimation may lead to inaccurate Topt estimates under future climate scenarios, underscoring the need to incorporate variable thermal acclimation responses of Topt into Earth System Models.
Water mass specific genes dominate the Southern Ocean microbiome
Authors: Faure Emile , Pommellec Jolann , Noel Cyril , Cormier Alexandre , Delpech Lisa-Marie , Eren Murat , Fernandez-Guerra Antonio , Vanni Chiara , Fourquez Marion , Houssais Marie-Noëlle , Silva Corinne Da , Gavory Frederick , Perdereau Aude , Labadie Karine , Wincker Patrick , Poulain Julie , Hassler Christel , Lin Yajuan , Cassar Nicolas , Maignien Lois
Published: January 2025

The Southern Ocean (SO) plays a key role in regulating global biogeochemical cycles and climate, yet microbial genes sustaining its biological activity remain poorly characterized. We introduce a comprehensive SO microbial genes collection from 218 metagenomes sampled during the Antarctic Circumnavigation Expedition, the majority of which are missing from functional databases. 38% even lack homologs in current reference marine gene catalogs, defining a singular genetic seascape. We show that SO gene assemblages exhibit a common polar signature with the Arctic Ocean while being structured by water masses at the SO-scale. We analyze genomic markers of diverse SO biomes, focusing on adaptations to organic matter consumption in the blooming Mertz polynya and temperature-dependent trace metal utilization by the ubiquist Bacteria Pelagibacter. Our work takes a step towards a more comprehensive understanding of SO’s plankton ecology and evolution, capturing the current state of the unique microbial diversity in this rapidly changing Ocean.
Eosinophils Enhance Granuloma-Mediated Control of Persistent Salmonella Infection
Authors: Monack Denise , Butler Daniel , Luccia Blanda Di , Vilches-Moure José
Published: January 2025

Salmonella enterica can persist asymptomatically within tissues for extended periods. This remarkable feat is achieved through intricate host-pathogen interactions in immune cell aggregates called granulomas, wherein Salmonella find favorable cellular niches to exploit while the host limits its expansion and tissue dissemination. Here, using a mouse model of persistent Salmonella infection, we identify a host-protective role of eosinophils in control of Salmonella Typhimurium (STm) infection within the mesenteric lymph nodes (MLN), the main lymphoid tissue of STm persistence. Combining spatial transcriptomics and experimental manipulations, we found that macrophages responding to STm infection recruited eosinophils in a C-C motif chemokine ligand 11 (CCL11)-dependent manner and enhanced their activation. Eosinophil deficiencies increased Salmonella burdens, which was associated with altered granuloma size and impaired type-1 immunity in the MLN. Thus, eosinophils play a vital role in restraining Salmonella exploitation of granuloma macrophages at a key site of bacterial persistence.
Immune targets for schistosomiasis control identified by a genome-wide association study of African snail vectors
Authors: Steinauer Michelle , Pennance Tom , Tennessen Jacob , Spaan Johannie , McQuistan Tammie , Ogara George , Rawago Fredrick , Andiego Kennedy , Mulonga Boaz , Odhiambo Meredith , Mutuku Martin , Mkoji Gerald , Loker Eric , Odiere Maurice
Published: January 2025

Schistosomiasis, a neglected tropical disease, is transmitted by freshwater snails. Interruption of transmission will require novel vector-focused interventions. We performed a genome-wide association study of African snails, Biomphalaria sudanica, exposed to Schistosoma mansoni in an endemic area of high transmission in Kenya. Two snail genomic regions, SudRes1 and SudRes2, were significantly associated with snail immunity to schistosomes. SudRes1 includes receptor-like protein tyrosine phosphatases while SudRes2 includes a class of leucine-rich repeat-containing G-protein coupled receptors, both comprising diverse extracellular binding domains suggestive of host-pathogen interaction. Resistant and susceptible haplotypes show numerous coding differences including presence/absence of entire genes. No loci previously tied to schistosome resistance in neotropical snail species showed any association with compatibility suggesting that loci involved in the resistance of African vectors are distinct. Snail ancestry was also strongly correlated with parasite compatibility. These results will inform future efforts to predict and manipulate immunity of a major schistosome vector.
Likely pathogenic variants of SDC3, KCNA2, KCNK1, KCNK16 and HSF1 are in support of acquired irreversible PIEZO2 channelopathy in ALS onset
Authors: Sonkodi Balázs , Nagy Zsófia Flóra , Keller-Pintér Anikó , Klivényi Péter , Széll Márta
Published: January 2025

Amyotrophic lateral sclerosis is a multisystem progressive neurodegenerative disease. A recent theory of ALS proposed that the disease initiating primary damage is an acquired irreversible intrafusal proprioceptive terminal PIEZO2 channelopathy with underlying genetic and environmental risk factors. Underpinning this theory that these intrafusal proprioceptive terminal PIEZO2 ion channels initiate an ultrafast proton-based oscillatory signaling to motor neurons through VGLUT1 and to the hippocampus through VGLUT2. This acquired progressive and irreversible intrafusal proprioceptive terminal PIEZO2 channelopathy may gradually degenerate motor neurons in which process Kv1.2 ion channels are gradually depleted. Furthermore, it also gradually depletes heat shock transcription factor-1 in the hippocampus, hence negatively affecting adult hippocampal neurogenesis. In addition, not only PIEZO2-PIEZO2 crosstalk is fully disrupted progressively in ALS between proprioceptive primary afferent terminals and hippocampus due to lost PIEZO2 initiated cross-coupled Huygens synchronization, but PIEZO2-PIEZO1 crosstalk is also disrupted on the periphery. Syndecans, especially syndecan-3 in the nervous system, are critical players in the maintenance of this PIEZO crosstalk. The detected charge altering variants of syndecan-3 likely promotes the impairment of the PIEZO crosstalk, and the progressive loss of the proposed proton-based signaling to motor neurons and to the hippocampus as well. Variants of KCNA2 may also facilitate the faster loss of Kv1.2 ion function on motor neurons when PIEZO channelopathy prevails, not to mention that potassium current rectifying ion channels encoding KCNK1 and KCNK16 variants may also propel ALS disease process and provide the autoimmune-like pathogenic background. Moreover, PIEZO2 channelopathy likely promotes diminishing heat shock transcription factor-1 function in the hippocampus in the presence of the identified HSF1 variants, leading to impaired adult hippocampal neurogenesis.
Multi-omics Approaches to Uncover Liquid-Based Cancer-Predicting Biomarkers in Lynch Syndrome
Authors: Kärkkäinen Minta , Sievänen Tero , Korhonen Tia-Marje , Tuomikoski Joonas , Pylvänäinen Kirsi , Äyrämö Sami , Seppälä Toni T. , Mecklin Jukka-Pekka , Laakkonen Eija K. , Jokela Tiina
Published: January 2025

Background
Lynch syndrome is a genetic cancer-predisposing syndrome caused by pathogenic mutations in DNA mismatch repair (path_MMR) genes. Due to the elevated cancer risk, novel screening methods, alongside current surveillance techniques could enhance cancer risk stratification. Here we show how multi-omics integration could be utilized to pinpoint cancer-predicting biomarkers in Lynch Syndrome. We studied which blood-based circulating microRNAs and metabolites could predict Lynch Syndrome cancer occurrence within a 5.8-year prospective surveillance period.
Methods
The study cohort consisted of 116 Lynch Syndrome carriers who were healthy at the time of sampling, of whom 17 developed cancer during the surveillance. Principal Coordinate Analysis and Canonical Correlation Analysis were used to explore the relationships between single and multi-omics data, enabling the identification of patterns and correlations across different biological layers. Weighted Correlation Network Analysis was used to identify omics-level co-expression modules and to study how these modules are associated with future cancer incidence or path_MMR variant. Lasso Cox regression was used to identify cancer-predicting biomarkers. The initial model was internally validated by splitting the data randomly into 5 training and corresponding validation datasets. Biological functions of future cancer-associated circulating microRNAs were studied by conducting pathway analyses using miRWalk.
Results
Weighted Correlation Network Analysis revealed a circulating microRNA co-expression module significantly associated with future cancer incidence. The identified microRNAs regulate cancer-related pathways including PI3K/Akt signaling pathway. Also, the analysis detected a circulating metabolite module, consisting of ApoB containing lipoprotein classes, (low-, intermediate-, and very low-density lipoproteins), and included cholesterols, as well as phospholipids and sphingomyelins, that had distinct levels between the path_MMRvariants. Three biomarkers- hsa-miR-101-3p, hsa-miR-183-5p, and the among of triglycerides in high-density lipoprotein particles (HDL_TG)- significantly predicted cancer risk based on Lasso Cox regression, with a C-index of 0.76 (p-value = 0.0007), where elevated levels of these biomarkers were indicators of increased hazard ratio. In the internal validation, the model had an average C-index of 0.72.
Conclusions
The multi-omics approach and the identified biomarkers offer a promising tool for cancer risk identification in Lynch Syndrome while also uncovering underlying systemic molecular mechanisms.
Fluence rate-dependent kinetics of light-triggered liposomal doxorubicin assessed by quantitative fluorescence-based endoscopic probe
Authors: Rohrbach Daniel J. , Carter Kevin A. , Luo Dandan , Shao Shuai , Aygun-Sunar Semra , Lovell Jonathan F. , Sunar Ulas
Published: January 2025

Liposomal doxorubicin (Dox), a treatment option for recurrent ovarian cancer, often suffers from suboptimal biodistribution and efficacy, which might be addressed with precision drug delivery systems. Here, we introduce a catheter-based endoscopic probe designed for multispectral, quantitative monitoring of light-triggered drug release. This tool utilizes red-light photosensitive porphyrin-phospholipid (PoP), which is encapsulated in liposome bilayers to enhance targeted drug delivery. By integrating diffuse reflectance and fluorescence spectroscopy, our approach not only corrects the effects of tissue optical properties but also ensures accurate drug delivery to deep-seated tumors. Preliminary results validate the probe effectiveness in controlled settings, highlighting its potential for future clinical adaptation. This study sets the stage for in vivo applications, enabling the exploration of next-generation treatment paradigms for the management of cancer by optimizing chemotherapy administration with precision and control.
Impact of Power Law Coefficient on Buoyant Heat Transfer in Porous Trapezoidal Enclosures
Authors: M VIJAYA KUMARA V , M ASWATHA , Kumar.R Vasanth , C.B Hemanth Kumar , G Mohan Kumar , Thejaraju.R  , Manjunatha.C
Published: January 2025

The impact of the power-law coefficient on buoyant energy transfer in porous trapezoidal cavities is investigated in this study. The analysis focuses on non-Newtonian fluids, where the flow behaviour deviates from the classical Newtonian model and the power-law coefficient plays a important role in defining the fluid’s rheological properties. Partial differential equations are formulated using the stream function approach and solved with an in-house MATLAB code and validated against previously published work .The cavity geometry combined with a porous medium, introduces complex thermal and flow interactions. The study examines how varying the power-law coefficient influences heat transfer rates, velocity profiles and temperature distribution within the cavity. Numerical simulations are conducted under different Rayleigh numbers (Ra = 100 to 2000) and boundary conditions demonstrating that the power-law coefficient significantly affects the thermal performance of the system. Results indicate that higher power-law coefficients enhance convective heat transfer, while lower coefficients lead to more diffusive heat transport. This research provides valuable insights into optimizing energy transfer in industrial applications involving Newtonian and non-Newtonian fluids in porous media.
Robust Estimates of Earth System Predictability of the 1st kind using the CESM2 Multiyear Prediction System (CESM2-MP)
Authors: Kim Yong-Yub , Lee June-Yi , Timmermann Axel , Chikamoto Yoshimitsu , Lee Sun-Seon , Kwon Eun Young , Park Wonsun , Hasan Nahid A. , Bethke Ingo , Fransner Filippa , Karwat Alexia , Subrahmanian Abhinav R. , Franzke Christian L. E.
Published: January 2025

Here we present a new seasonal-to-multiyear Earth prediction system (CESM2-MP) based on the Community Earth System Model version 2 (CESM2). A 20-member ensemble which assimilates oceanic temperature and salinity anomalies provides the initial conditions for 5-year predictions from 1960 to 2020. We analyze skills using pairwise ensemble statistics, calculated among individual ensemble members (IM) and compare the results with the more commonly used ensemble mean (EM) approach. This comparison is motivated by the fact that an EM of a nonlinear dynamical system generates – unlike reality – a heavily smoothed trajectory, akin to a slow manifold evolution. However, for most autonomous nonlinear systems, the EM does not even represent a solution of the underlying physical equations, and it should therefore not be used as an estimate of the expected trajectory. The IM-based approach is less sensitive to the ensemble size than EM-based skill computations, and its estimates of potential predictability are closer to the actual skill. Using IM-based statistics helps to unravel the physics of predictability patterns in CESM-MP and their relationship to ocean-atmosphere-land interactions and climate modes. Furthermore, the IM-based method emphasizes potential predictability of the 1st kind which is associated with the propagation of the initial conditions. In contrast, the EM-based method is more sensitive to predictability of the 2nd kind, which is associated with the external forcing and time-varying boundary conditions. Calculating IM-based skills for the CESM-MP provides new insights into predictability sources due to ocean initial conditions and helps delineate and quantify forecast limits of internal variability.
Destination Image of Lake Salda in the Lens of Tourists and Locals
Authors: CAN GABERLİ Yağmur , GÜVENOL Buğcan , GÜLER Mehmet Emre
Published: January 2025

Salda, included in the World's Top 100 Geological Heritage List in 2024 and declared as the representative of Mars on Earth, is a remarkable destination thanks to its natural beauty and rare features. The number of visitors seeking to discover this unique destination is increasing day by day, driven by its uniqueness and promotional activities. In this context, it is important to determine the image of this destination. The study aims to determine the destination image of Lake Salda from the perspective of domestic tourists and locals. A qualitative research design was adopted, and interviews were conducted with a total of 30 participants using the purposeful sampling technique. The data was examined through reflexive thematic analysis using the MaxQDA program. It was concluded that Lake Salda has a positive destination image with its natural beauties and safe environmental perception, but the problems experienced in the conservation and promotional processes of the area, the deficiencies in the infrastructure and superstructure in the destination, and the unconscious behaviors of individuals are factors that negatively affect this image. Future studies can examine the sustainability of the destination in more detail, determine strategies for awareness-raising practices, and focus on the current status of alternative accommodation opportunities in the area.
WASTE WATER CIRCULARITY AND ITS RELATED INCENTIVES IN INDIA
Authors:   MBA (RM) Batch of 2020-22, XIM University, Bhubaneswar, India., Panda Asyukta , Kumar Panda Asish ,   Department of Management Studies, NALSAR University of Law, Hyderabad, India.
Published: January 2025

In todays world, rapid population growth and urbanization have intensified pressure on natural resources, particularly water. Approximately half of the global population, around 4 billion people, experience water shortages for at least one month annually, with projections indicating that 1.8 billion may face absolute water scarcity by 2025. Wastewater exacerbates this strain, with untreated discharge posing severe health and environmental risks. In India, addressing wastewater circularity is imperative for sustaining a population of over 1.3 billion, supporting industries, curbing pollution, and conserving resources. Although policies exist at both national and state levels, only 11 states have operationalized wastewater reuse policy wise. Focusing on the basis for wastewater circularity, the need for incentives is paramount. The kinds of incentives, current scenario in India and way forward have been discussed in the paper.
Orofaciodigital syndrome type I in a twelve-year-old child
Authors: Safonova M. P. , Zaykova N. M. , Serebryakova O. A. , Potrokhova E. A. , Baleva L. S.
Published: January 2025

Orofaciodigital syndrome type I is a rare (orphan) disease with a prevalence of 1:50,000 to 1:250,000, characterized by craniofacial, oral, and digital anomalies, as well as involvement of internal organs, including the kidneys. Orofaciodigital syndrome type I is inherited in an X-linked dominant manner, primarily affecting females, and arises from defects in the formation of primary cilia. This article presents a clinical case of a 12-year-old patient diagnosed with orofaciodigital syndrome type I, along with a review of the pathogenic mechanisms and clinical manifestations of the syndrome based on literature data. The article demonstrates the significant genetic heterogeneity and clinical variability among patients with mutations in the OFD1 gene.
Developmental disorder and facial dysmorphia syndrome caused by a mutation in the MORC2 gene
Authors: Nikolaeva E. A. , Dzhivanshiryan G. V. , Komarova O. N. , Bochenkov S. V. , Nikolskayav A. Yu. , Tokareva D. Yu. , Voinova V. Yu.
Published: January 2025

Pathogenic nucleotide variants in the MORC2 gene have recently been linked to axonal peripheral neuropathy (Charcot–Marie–Tooth disease, axonal type 2Z) and the syndrome of developmental and growth disorders, facial dysmorphia, and axonal neuropathy (DIGFAN syndrome). DIGFAN syndrome is marked by early onset and multisystem symptoms, particularly affecting the visual and auditory organs. In approximately 30% of cases, mitochondrial encephalomyopathy is initially considered a possible diagnosis. In a girl with a heterozygous MORC2 gene mutation, the presence of DIGFAN syndrome was confirmed. Her clinical profile included motor, speech, and physical developmental delays, along with visual and auditory impairments, peripheral neuropathy, facial dysmorphia, Lee-like changes on MRI, and moderate lactic acidemia. Following metabolic therapy targeting intracellular energy exchange processes, alongside a rehabilitation program, some improvement in her condition and normalization of blood lactate levels were observed. The importance of early diagnosis is highlighted, as it supports the timely initiation of metabolic therapy and other therapeutic interventions under specialist supervision. Confirming the diagnosis is critical for anticipating disease progression and providing genetic counseling for the proband and their family.
Selected socio-economic aspects of the integration of Ukrainians: Evidence from the Czech Republic
Authors: Danielova Linda , Prokešová Radka , Vacková Jitka , Švestková Renata , Shuranova Lesia
Published: January 2025

The war against Ukraine has led to a substantial influx of Ukrainian migrants into many countries, including the Czech Republic. As these migrants navigate the integration process, a key aspect of their journey is often their entry into the Czech labor market. The paper aims to identify and analyze selected socio-economic aspects associated with the integration of Ukrainian immigrants, with a specific focus on their Czech language fluency, length of stay in the Czech Republic, and the underlying reasons for their migration. This quantitative research was conducted using a self-designed questionnaire. Data collection took place in the first half of 2023. The sample consisted of 158 Ukrainian immigrants. The results showed statistically significant connections between the subjective assessment of how the respondents communicate in the Czech language with the field in which they work (p < 0.05), the perception of economic status (p < 0.001), the subjective assessment of the difficulty of finding a job (p < 0.001), satisfaction with work (p < 0.005), and intention to change jobs (p < 0.005). Additionally, there are correlations between length of stay and use of original qualification (p < 0.01), reasons for migration and difficulty finding work (p < 0.05), and between subjective evaluation of the difficulty of finding a job in the Czech Republic in relation to coming to the Czech Republic (p < 0.01). The results can be used by counseling centers for foreigners and potential employers to improve Ukrainian employment opportunities in the Czech labor market.
AcknowledgmentsThis study is supported by the project GA JU 101/2022/S “Selected aspects of integrating foreigners living in the Czech Republic from the perspective of society and the labor market.”
Relação entre eficiência dos gastos públicos nos cursos presenciais de graduação em administração do brasil e níveis de disclosure
Authors:   , Batista Lissandro Arielle Vale
Published: January 2025

A presente dissertação visa investigar a relação existente entre a eficiência dos gastos públicos
com o nível de disclosure dos cursos presenciais de graduação em administração das
instituições públicas brasileiras. O estudo é de suma importância para identificar o nível de
eficiência dos cursos quanto à aplicação de recursos públicos, assim como o nível de
transparência das informações dos cursos mediante suas páginas digitais. A sociedade cobra
intensamente eficiência do gasto público nas instituições públicas, principalmente nas
universidades públicas, tendo em vista os questionamentos sobre o investimento na educação
nos últimos tempos. A transparência dos dados e o acesso à informação são, na atualidade,
tópicos que os órgãos de controle e a sociedade visam demasiadamente nas instituições
públicas. Esta pesquisa possui natureza quantitativa, utilizando métricas de programação linear
e estatística. O trabalho contou com uma amostra de 166 cursos presenciais de graduação em
administração, sendo 91 de universidades federais e 31 de universidades estaduais. Para atingir
o objetivo da pesquisa, utilizou-se a Análise Envoltória de Dados (DEA), modelo Banker,
Charnes e Cooper (BCC), orientada pra output, para avaliar o nível de eficiência dos cursos.
Mensurou-se o nível de disclosure por meio de pesquisas nas páginas oficiais dos cursos de
administração, definindo-se 71 itens para análise. Utilizou-se a regressão logística binária para
verificar a conformidade do modelo utilizado. O estudo contribui para a literatura, pois une dois
temas bastante utilizados nas instituições públicas, porém que não foram abordados em
conjunto. Assim como, pode contribuir politicamente visando melhorias na padronização das
páginas eletrônicas por parte das IES. amenta de gestão para as Instituições Públicas. Os
resultados mostraram que a maioria dos cursos não são eficientes e que o nível de disclosure
dos cursos é muito baixo. As instituições federais se destacaram na média dos níveis de
eficiência e de disclosure, enquanto as estaduais obtiveram as menores médias.
Navigating travel writing and digital humanities: The Anglophone Travellers in Portugal project and its visual narratives
Authors: Rodrigues Maria Beatriz , Castanheira Maria Zulmira
Published: January 2025

This article aims to present the “Anglophone Travellers in Portugal” project carried out at CETAPS, focusing on its visual dimension. After decades of analysing the works using close reading methods, we have adopted Digital Humanities approaches to deal with the large amount of data generated. With these notions in mind, we have taken on data visualization tools as a way of analysing, interpreting and communicating our findings related to the travel narratives we have gathered in our database, written by Anglophone authors who travelled in Portugal. These travellers show us a different perspective on Portuguese culture, history and geography and, in order to draw meaning from their narratives, we have to look at them in an interdisciplinary way. This will be possible through the advancement of the project’s visual identity, both by developing the visuals of the associated repository and website and by the inclusion of digitised images of the illustrations present in the works incorporated in our database. Therefore, in this article, we will start by demonstrating the importance of illustrations and images in literary works; we will then delimit the illustrations that can be found in the “Anglophone Travellers in Portugal” project,and we will finish by describing the process of scanning, categorizing and organizing the generated images. This account will allow us not only to share our findings with the publicbut also to pave the way for new stories, discoveries and participations
Paper Dolls Female Stereotypes in Anglo-American Music from the 1950s and the 1960s
Authors: Alarcão Miguel
Published: January 2025

This articleputs up for a briefcultural comment some videoclipsof Anglo-American songs from the 1950s and the 1960s, which, while displaying the visual centrality of women and the beauty of the female body, also (re)produce stereotyped gender images, as well as overt or implicit machoassumptions and prejudices
The use of SLAB51TM probiotics in dogs with acute and chronic gastrointestinal disease in a veterinary teaching hospital
Authors: Willemse T.W.J. , Salavati Schmitz S.
Published: January 2025

Acute and chronic gastrointestinal (GI) problems remain common conditions in dogs presented in primary and referral practice. For canine chronic enteropathies (CE), traditional treatment trials are being challenged. In particular, antibiotic use is increasingly scrutinized, and recommendations include replacement by probiotics. However, probiotic-responsive CE (PRE) is not well described yet. The authors hypothesize that this condition might exist and aimed to characterize these enteropathies and describe dogs that could fall into this category by retrospectively assessing response to probiotic treatment. Medical files of dogs receiving the most commonly used probiotic mixture at the authors’ hospital, i.e. SLAB51™, were reviewed. Information about signalment, presenting signs, diagnosis, concurrent treatment, length of treatment and outcome was collected. Dogs with chronic disease supplemented with SLAB51™ (either alone or concurrently to other treatments) were further described to identify cases of PRE. Thirty-seven dogs met the inclusion criteria, of which 29 had chronic GI signs and 24 dogs had a CE. Seven of eight dogs in the acute group and 18/29 dogs in the chronic group responded favorably to treatment. Seven dogs received SLAB51TM without significant concurrent treatment, out of which six had a favorable response (two partial and four full resolution of clinical signs). While the number of cases in which the response to probiotics alone could be assessed, was small, in this study, a role for the use of SLAB51™ probiotics is suggested in cases of acute and chronic enteropathies either alone or alongside other management changes such as dietary interventions.
In 1996 brak boviene spongiforme encefalopathie (BSE) uit in onze streken
Authors: Desmet J. , Devriese L.
Published: January 2025

Boviene spongiforme encefalopathie of ‘dolle koeienziekte’ werd voor het eerst in 1985 vastgesteld in het Verenigd Koninkrijk. Gezien de meestal erg lange incubatietijd (tot meerdere jaren), mag aangenomen worden dat de ziekteoorzaak al veel eerder aanwezig was. Voorlopig bleef het rustig daaromtrent. Het was wellicht een van de talloze eigenaardigheden van ons biologisch bestand. Maar tien jaar later, zowat dertig jaar geleden, werden de gemoederen hevig beroerd door deze toen schijnbaar nieuw opgedoken ziekte bij runderen. Die vormde niet alleen een gevaar voor de rundveestapel, maar bleek nauw verwant te zijn met twee vreselijke ziekten waartegen geen kruid gewassen was: scrapie bij schapen en geiten en de - gelukkig - zeer zeldzame ziekte van Creutzfeldt-Jacob (CJD) bij mensen (rond vijftig tot zestig jaar), beide onafwendbaar fataal verlopende neuropathieën.
Telediergeneeskunde: standpunt van de Faculteit Diergeneeskunde, UGent
Authors: De Vliegher S. , Garmyn A. , Maes D. , Opsomer G. , van Loon G. , Saunders J. , Daminet S. , Martens A.
Published: January 2025

Recent werd op vraag van de Hoge Raad van de Orde der Dierenartsen door de Faculteit Diergeneeskunde een standpunt geformuleerd rond telediergeneeskunde. Dit standpunt werd op de Faculteitsraad van 19 juni 2024 goedgekeurd en overgemaakt aan de Orde. Binnen dit standpunt - dat we hier integraal publiceren - wordt ingegaan op de definitie van telediergeneeskunde, worden de vigerende wettelijke en deontologische bepalingen niet-limitatief opgesomd, worden mogelijke toepassingen beschreven, wordt nagegaan wat vandaag in de praktijk al gebeurt en onder de ruime noemer van telediergeneeskunde valt, wordt stilgestaan bij wat de toekomst mogelijkerwijze brengt en worden aanvullende bedenkingen geformuleerd alvorens te eindigen met enkele conclusies. Dit standpunt vormt een aanzet waarmee de praktijkdierenartsen, de Orde, de Overheid en de Faculteit aan de slag kunnen. Volledigheid wordt niet geclaimd, veeleer wordt een denkoefening opgestart die doorheen de tijd zal evolueren en die open staat voor aanvullingen, opmerkingen en kritiek.
Acknowledgment to Reviewers of OBM Integrative and Complementary Medicine in 2024
Authors: Editorial Office OBM Integrative and Complementary Medicine
Published: January 2025

The editors of OBM Integrative and Complementary Medicine would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web of Science Reviewer Recognition Service (formerly Publons) (https://webofscience.com/wos/) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.
Acknowledgment to Reviewers of OBM Neurobiology in 2024
Authors: Editorial Office OBM Neurobiology
Published: January 2025

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web of Science Reviewer Recognition Service (formerly Publons) (https://webofscience.com/wos/) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful for the time reviewers donate to our journals and the contribution they make.
Acknowledgement to Reviewers of OBM Transplantation in 2024
Authors: Editorial Office OBM Transplantation
Published: January 2025

The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web of Science Reviewer Recognition Service (formerly Publons) (https://webofscience.com/wos/) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful for the time reviewers donate to our journals and the contribution they make.