bluuebunny/crossref_metadata_2025 huggingface dataset:
Sunn Pest Damaged and Healthy Wheat Grains Dataset Across Different Species
Authors: Pervan-Akman Nergis , Çolak Melike , Özkan Özgü , Tümer-Sivri Talya , Olgun Murat , Berkol Ali , Budak-Başçiftçi Zekiye , Ayter-Arpacıoğlu Gözde , Sezer Okan , Ardıç Murat
Published: April 2023

Sunn pest is one of the most crucial noxious species in agriculture. As the sunn pest penetrates and makes damage to the grains, they can no longer be utilized to make bakery goods like bread, pasta, and other baked foods since they become unusable. Therefore, analysis and detection of damaged wheat grains are necessary for production to continue. We recommend that the dataset could be used for analysis and segmentation of the wheat grains, detection of the sunn pest damage condition, and classification of the 6 species of which the dataset consists. As mentioned, in our dataset, there are 6 different species of wheat, including Bezostaja, Müfitbey, Nacibey, Sönmez-2001, Tosunbey, and Ekiz, which are the species that were made in Türkiye. Our dataset differs from the others due to its various species and the condition, whether it is healthy or sunn pest damaged or broken wheat grain, and because the dataset is a multiclass one, it can be used for the classification of the varieties. On the other hand, when the sunn pest damage condition is taken into account, the dataset is suitable for the detection of the sunn pest damage. In addition to that, the dataset includes grains that touch each other which makes it more applicable to problems that arise in real-life. The dataset consists of 83 sunn pest damaged and 87 healthy wheat images. In addition, there are 170 images that contain 3565 wheat grains. As can be observed, the dataset contains a variety of wheat species with sunn pest affected which displays that the promised dataset is suitable for numerous machine learning problems such as classification, segmentation, and detection.
The Impact of Bilirubin on 7α- and 7β- Hydroxysteroid Dehydrogenases: Spectra and Docking Analysis
Authors: Ji Qingzhi , Chen Jiamin , Zhu Luping , Wang Ruiyao , Wang Bochu
Published: April 2023

7α- and 7β-hydroxysteroid dehydrogenases (HSDH) are a pair of enzymes that can catalyze the isomerization of hydroxyl group at site 7 of bile acids. In previous study, we found that the activities of 7α- and 7β-HSDH can be inhibited by bilirubin. In order to clarify the impact, the effects of bilirubin on enzymes were studied by kinetics, spectrum and docking analysis. Relative activity of 7α-HSDH remained less than 40 % under 1 mM bilirubin, for 7β-HSDH, only 18 % activity left at the same condition. Using taurochenodeoxycholic acid (TCDCA) as substrate, the Km of 7α-HSDH was up to 0.63 mM from 0.24 mM after binding with bilirubin, the Km of 7β-HSDH rose from 1.14 mM to 1.87 mM for the catalysis of tauroursodeoxycholic acid (TUDCA). The affinity of 7α- and 7β-HSDH to substrate decreased with the effect of bilirubin. The binding of bilirubin with 7α- or 7β-HSDH were analyzed by UV–Vis spectra, Fluorescence spectra and Circular dichroism (CD) spectra. The results reflected that bilirubin caused a slight change in the secondary structure of 7α- or 7β-HSDH, and the changes were correlated with the ratio of bilirubin to enzyme. 10 candidate molecular docking results were presented to reflect the binding of bilirubin with 7α- or 7β-HSDH and to explore the inhibition mechanism. This research not only provides the more in-depth understanding of 7α- and 7β-HSDH, but also reminds us to avoid the inhibition of bilirubin on hydroxysteroid dehydrogenases.
Genome-Wide Mining of Selaginella moellendorffii for Hevein-Like Lectins and Their Potential Molecular Mimicry with SARS-CoV2 Spike Glycoprotein
Authors: Alsolami Ahmed , Dirar Amina I , Konozy Emadeldin H. E , Osman Makarim El-fadil M , Ibrahim Mohanad A , Alshammari Khalid Farhan , Alshammari Fawwaz , Alazmi Meshari , Said Kamaleldin B
Published: April 2023

Multidisciplinary research efforts on potential COVID-19 vaccine and therapeutic candidates have increased since the pandemic outbreak of SARS-CoV-2 in 2019. This search has become imperative due to the increasing emergences and limited widely available medicines. The presence of bioactive anti-SARS-CoV-2 molecules was examined from various plant sources. Among them is a group of proteins called lectins that can bind carbohydrate moieties. In this article, we present ten novel, chitin-specific Hevein-like lectins that were derived from Selaginella moellendorffii v1.0's genome. The capacity of these lectin homologs to bind with the spike protein of SARS-CoV-2 was examined. Using the HDOCK server, 3D-modeled Hevein-domains were docked to the spike protein's receptor binding domain (RBD). The Smo446851, Smo125663, and Smo99732 interacted with Asn343-located complex N-glycan and RBD residues, respectively, with binding free energies of -17.5, -13.0, and -26.5 Kcal/mol. The normal-state analyses via torsional coordinate association for the Smo99732-RBD complex using iMODS is characterized by overall higher stability and minimum deformity than the other lectin complexes. The three lectins interacting with carbohydrates were docked against five individual mutations that frequently occur in major SARS-CoV-2 variants. These were in the spike protein’s receptor-binding motif (RBM), while Smo125663 and Smo99732 only interacted with the spike glycoprotein in a protein-protein manner. The precursors for the Hevein-like homologs underwent additional characterization and their expressional profile in different tissues was studied. These in-silico findings offered potential lectin candidates targeting key N-glycan sites crucial to the virus's virulence and infection.
Influence of Different Packages and Storage Temperatures on the Yield and Quality of Edible Allium Species
Authors: Ivanova Maria I. , Yanchenko Elena , Kashleva Anna
Published: April 2023

The genus Allium L. attracts the attention of researchers due to the presence of valuable medicinal, nutritional and decorative properties, adaptive capabilities, resistance to pests and diseases, ecological plasticity in its representatives, which contributes to the competitiveness of species and the manifestation of a high degree of adaptation outside natural areas and wide geographical distribution. Allium resources in Russia are a potential source of genes for expanding the genetic base of agricultural crops. The leaves of Allium crops have a short freshness period and quickly deteriorate due to spoilage and loss of water. Spoilage and loss of water affect their freshness and properties. The aim of the work was to establish the yield and change in the quality of green leaves of Allium species introduced into the Moscow region during short-term storage, depending on the type of packaging, storage period and temperature. 4-5-year-old plants of 4 species (A. altyncolicum, A. chyatophorum, A. nutans and A. turkestanicum) were grown on the collection plot of perennial onions of VNIIO, a branch of the FGBNU FNTSO. In the conditions of the Moscow region, the yield per leaf generation varied from 2.7 kg/m2 (A. altyncolicum) to 4.9 kg/m2 (A. cyathophorum). The maximum yield of marketable products was noted in hermetically sealed plastic bags when stored for 10 days at a temperature of +6 ... + 80С in a refrigerator with controlled conditions: A. turke-stanicum - 70.0%, A. cyathophorum - 75.5%, A. altyncolicum - 84.9%, A. nutans - 92.9%. However, an increase in the dry matter content (10.1-15.5%) was found during storage in an open polymer box in all tested species. The maximum content of vitamin C during storage in hermetically sealed bags with a density of 100 μm was found in A. altyncolicum (37.1 mg%) and A. nutans (42 mg%). In other species, the maximum value of this indicator was noted before storage. A slight increase in the amount of sugars after storage for 10 days was noted in species with a linear leaf shape when stored in a polymer box. Temperature control is the most effective approach to extend the shelf life of fresh green leaves by measuring its weight loss and vitamin C. Packaging cannot prevent spoilage of vegetables but can protect it against contamination, damage and excessive moisture loss.
The Michigan Clinical Consultation and Care model (MC3 Perinatal): A Novel Approach to Perinatal Mental Health Care
Authors: Muzik Maria , Menke Rena A. , Issa Meriam , Fisk Chelsea , Charles Jordan , Jester Jennifer M.
Published: April 2023

Mood and anxiety disorders affect pregnant people and their families at increased rates throughout the perinatal period. Geographic, financial, and social barriers persist in identification and access to care that preclude adequate diagnosis and treatment of anxiety and mood disorders. These challenges have been exacerbated by the COVID-19 pandemic, particularly for Black and Indigenous People and People of Color (BIPOC) who already experience increased risk for adverse mental health outcomes and faced structural barriers to accessing perinatal mental health care at baseline. The literature shows that integrated care can improve mental health outcomes and save billions of dollars in annual healthcare costs. This study evaluated a novel statewide integrated care effort designed to facilitate access to perinatal mental health care for OB/GYN patients. In addition to enrollment data, variables studied were maternal program satisfaction, retention rates, and preliminary maternal mental health outcomes. 285 patients were ever referred for care. Of this, we contacted 259 patients (91%) and enrolled 209 (72%). Of the 209, 48 were lost to follow up, while 107 remained enrolled at the time of data analysis. 54 patients met their treatment goals. 97% of individuals asserted they were satisfied with the services they received. Black race and public insurance predicted faster attrition from treatment; risk for interpersonal violence exposure and substance use were not related to attrition. Preliminary mental health outcomes showed significant decreases in anxiety and depression, with the most dramatic decreases in the first month of treatment. The MC3 Perinatal care program is a viable, patient-endorsed collaborative care model that increases access to perinatal mental health and facilitate access to outside resources.
To Explore the Efficacy of Modified Altemeier Procedure in the Treatment of Complete Rectal Prolapse
Authors: Zhai Yuze , Wang Benjun , Han Weiwei Han , Yu Bianfang , Liu Congcong , Gao Qianfu , Wang Shanchao , Fang Yueting
Published: April 2023

Abstract

Objective：To explore the efficacy of modified Altemeier procedure in the treatment of complete rectal prolapse.

Method and Main outcome measures:The enrolled patients with complete rectal prolapse were divided into traditional and modified groups according to the surgical approach.The primary outcomes included complication rates, time and severity of postoperative recurrence, changes in pre- and postoperative Wexner anal incontinence scores and ED-5Q-5L quality-of-life autonomy scores. Secondary outcomes included operative time, intraoperative bleeding, and length of hospital stay.

Results:The overall complication rates were 33.33% and 6.67% and recurrence rates were 26.67% and 7% in the traditional and modified groups, respectively (P<0.05)；The duration of surgery in the traditional group was shorter than that in the modified group, but the intraoperative bleeding was significantly higher than that in the modified group, and all differences were statistically significant (P<0.05)；The length of stay and in the two groups, respectively, with no statistically significant difference (P>0.05)；The postoperative Wexner incontinence score and ED-5Q-5L quality of life in the modified group were found to be significantly better than those in the traditional group at 8 months postoperative follow-up, with statistically significant differences (P<0.05).

Conclusions:Pathological dilatation of the distal rectum may be another anatomical defect in complete rectal prolapse. The results of the clinical study confirmed the clinical effectiveness and safety of the modified Altmeyer procedure, which has high clinical application value.
Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
Authors: Matos Ricardo J. R. , Silva Jorge C. , Soares Paula I. P. , Borges João Paulo
Published: April 2023

Composite biomaterials that combine osteoconductive and osteoinductive properties are a promising approach for bone tissue engineering (BTE) since it allows osteogenesis stimulation while mimicking the extracellular matrix (ECM) morphology. In this context, the aim of the present research work was to produce polyvinylpyrrolidone (PVP) nanofibers containing mesoporous bioactive glass (MBG) 80S15 nanoparticles. These composite materials were produced by electrospinning technique. The design of experiments (DOE) was used to estimate the optimal electrospinning parameters to reduce average fiber diameter. The polymeric matrices were thermally crosslinked under different conditions, and the fiber’s morphology was studied using scanning electron microscopy (SEM). Evaluation of the mechanical properties of nanofibrous mats revealed a dependence on thermal crosslinking parameters and on the presence of MBG 80S15 particles inside the polymeric fibers. Degradation tests indicated that the presence of MBG led to a faster degradation of nanofibrous mats. On the other hand, MBG presence also leads to higher swelling capacity. The assessment of in vitro bioactivity in simulated body fluid (SBF) was performed in MBG pellets and PVP/MBG (1:1) composites to assess whether the bioactive properties of MBG 80S15 were kept when it was incorporated into PVP nanofibers. FTIR and XRD analysis along with SEM–EDS results indicated that a hydroxy-carbonate apatite (HCA) layer was formed on the surface of MBG pellets and nanofibrous webs after soaking in SBF over different time periods. In general, the materials revealed no cytotoxic effects on Saos-2 cell line. The overall results for the produced materials show the potential of the composites to be used in BTE.
Modelling of Laboratory Information Systems in Higher Education Based on Enterprise Architecture Planning for Optimizing Monitoring and Equipment Maintenance
Authors: Ifriza Yahya Nur , Veronika Trisni Wulandari , Suryarini Trisni , Supriyadi Antonius
Published: April 2023

It is possible to conduct scientific research, experiments, measurements, or training in a laboratory. Each department at FMIPA UNNES features several laboratories to complement class lectures for the students. Students can recognise concepts, cultivate scientific attitudes, and improve their critical thinking skills through lab practice. Utilising laboratory resources effectively and efficiently is expected of good laboratory management. Testing of lab equipment is required to ensure proper functionality and readiness for practicum use. Maintaining an eye on the equipment's condition and fixing any damage as soon as it becomes apparent is crucial for providing proof. The drawbacks of manually recording tool repairs are poor paperwork and equipment problems that are untraceable online. With the help of this study, the FMIPA UNNES environment departments will be able to monitor the upkeep of their lab equipment. The research approach starts with a literature review, followed by the first round of data collecting and observation, the design of an EAP-based system, system testing, system analysis, and system assessment. This research aims to create a product for the Monitoring Information System for the Maintenance of Laboratory Equipment using the SDLC (System Development Life Cycle) methodology. Testing involves the use of black box testing. The system's UAT grade of 88% implies that it is appropriate for use and may employ to simplify laboratory equipment management.
Implementation of K-Means Clustering for Optimization of Student Grouping Based on Index of Learning Styles in Programming Classes
Authors: Maryono Dwi , Budiyanto Cucuk Wawan , Pamungkas Allan Auri
Published: April 2023

This study aims to group students into study groups (classes) based on learning styles utilising K-Means Clustering technique  and Sum of Squared Error for cluster assessment. This study used type of learning style developed by Felder and Silverman, which includes four dimensions: (1) the learning process; (2) perception of learning; (3) information input; and (4) understanding of information. This study subjects were Universitas Sebelas Maret's students majoring in informatics Education consisting of 58 respondents. The results showed that the K-Means clustering approach with cluster evaluation using Sum of Squared Error produced the best clustering when the number of clusters was k=2. The cluster analysis showed that each class has different learning styles and characteristics. The first cluster (group) consists of 26 respondents and has the features of an active learning style in the learning process dimension, sensing in the learning perception dimension, visual in the information input dimension, and a balance between global and sequential in the information understanding dimension. Meanwhile, the second cluster (group)  consists of 32 respondents and has a reflective tendency in the learning process dimension, sensing in the learning perception dimension, visual in the information input dimension, and global in the information understanding dimension.
Research Trends in the Use of Augmented Reality in Engineering Education: A Bibliometric Analysis
Authors: Utami Nisaudzakiah , Setiawan Agus , Hamidah Ida
Published: April 2023

This study aims to report on the overall research trend of research progress in the Augmented Reality (AR) field in engineering education. The research method used is bibliometric analysis (BA) using VoSviewer. The data is taken from the Scopus database. The findings show an increasing trend in citations and publications showing interest in using AR over the last decade. AR research in engineering education started in 2006 until now. Screening of selected articles from 2012 to 2022. The screening process based on inclusion and exclusion included the chosen language in English and based on the publication of final articles, resulting in a total of 858 articles. The results reveal that augmented reality, engineering education, and mobile learning are the most used keywords in the article. In contrast, the focus of the new article tends to be on augmented reality. In addition, the results show that the latest articles mostly focus on virtual and mobile learning. The most frequently used words in the abstract are engineering education, student, e-learning, education, and teaching. Recent articles have largely focused on students' and teachers' knowledge of technology-based learning. Billinghurst, Dede, and Martin are the most cited authors in this field, as they are the principal authors of AR. The journals cited are Computers & Education, Coeur Workshop Proceedings, Computers in Human Behavior, and the Journal of Science Education and Technology. The journal is the most prominent on the use of technology in education.
Research-based learning in biology courses to train students critical thinking skills: Student's perception
Authors: Daryanes Febblina , Sayuti Irda
Published: April 2023

Critical thinking is an ability that has a specific purpose for empowering thinking activities in science education and other disciplines. This study aims to determine student perceptions of applying the Research Based Learning in training student’s critical thinking skills. This research is quantitative descriptive. This type of research is used to analyze data by describe or describe the data that has been collected as it is. The population in this study were all students of biology education, Riau University, while the sample in this study were biology education students in semester 3 of class A who took Biology Learning Media courses. The sampling technique is through purposive sampling. The instrument used is a student response questionnaire and observation sheets that emphasizes the description of the achievement of critical thinking indicators according to Marzano and interview sheets. The questionnaire data were analyzed by calculating the percentage of student responses and the interview data were analyzed qualitatively. The result showed that students gave a positive response to the Research Based Learning in training students’ critical thinking skills by 94% and were in the very good category. The indicators of “open thinking” and “able to provide ideas” are critical thinking indicators that get responses reaching 100%. In line with the observation results that the indicator "able to provide ideas" obtained the highest percentage, namely 88% in the very good category. Each stage in the Research Based Learning in this study provides opportunities for students to develop their critical thinking skills. The results of this study can be used as a reference for developing research-based learning strategies in other subjects.
Enhance student ict literacy and conceptual understanding using selm (simas eric learning model)
Authors: Darmawan Ericka , Trienita Giesty , Hartati Tri Asih Wahyu
Published: April 2023

The Biology learning process at MAN 2 Surakarta has yet to be able to utilize technology as adequate learning support. Students still use their gadgets for things that are not related to learning. The assignments given by the teacher have yet to make much use of technology. An innovative learning model is needed to bridge technological advances in the learning process. SELM (Simas Eric Learning Model) is used in learning to determine the effect of the model on ICT literacy and conceptual understanding of class XI MAN 2 Surakarta students. There are two research instruments for ICT literacy using questionnaires and conceptual understanding using pretest and posttest on excretory system material. This study used a quasi-experimental research type with a pretest-posttest non-equivalent control group design. The data analysis technique was divided into two questionnaires using normative tests and a pretest and posttest using the N-Gain and sample tests. The results showed that the experimental class got an ICT literacy score of 81.5%, and the control class got 75%. The value of students' understanding of the concept of the experimental class got a score of 51.6%, and the control class got a score of 24.8%. The SELM is significant for increasing students' understanding of concepts and being able to increase students' ICT literacy.
Osteoporosis Knowledge, Attitude and Practice among Doctor Of Physical Therapy Students
Authors:   Department of Physiotherapy, Isra Institute of Rehabilitation Sciences, Isra University, Hyderabad, Pakistan, Rehman Shamsa Abdul , Lalwani Kanwal ,   Department of Physiotherapy, Isra Institute of Rehabilitation Sciences, Isra University, Hyderabad, Pakistan, Mughal Rabbiah ,   Department of Physiotherapy, Isra Institute of Rehabilitation Sciences, Isra University, Hyderabad, Pakistan
Published: April 2023

Abstract: Background: Osteoporosis is a metabolic disease which is common globally. It is defined as decrease in bone mass and bone tissue destruction that causes decrease in bone strength and increase the chances of fractures. Over 200 million people are suffering from osteoporosis worldly and the number of individuals will increase greatly in coming decades due to aging and sedentary lifestyle. Knowledge combined with strategic planning related to preventive measures decrease its occurrence. Objective: The objective of this study was to evaluate the knowledge, attitude and practice of osteoporosis in students of physical therapy. Materials and Methods: A Questionnaire-Based survey was conducted at Department of Physiotherapy, Isra University Hyderabad in April 2021 to December. 2021. The study approval was given by Ethical Committee of Isra Institute of Rehabilitation Sciences, Isra University Hyderabad. 200 students from 3rd to final year were asked to complete the questionnaire. The knowledge, attitude and practice (KAP) of osteoporosis questionnaire consisted of 20 close ended questions. Results: A total of 200 were selected out of which 182 participants completely filled and returned the questionnaire. The mean age of participants was 22.31±1.86 years. Male participants were 34 (18.7%) and female participants were 148 (81.35%) in this study. High knowledge regarding osteoporosis was found among students with percentage of 99.45%. The participants showed positive attitude related to osteoporosis with percentage of 60.9%. These students also had positive impression towards management practices for osteoporosis with the percentage of 70.33%. Conclusion: This study concluded that the participants have better knowledge regarding osteoporosis. Further proper health education programs must be held in university to encourage them to adopt healthy practices about osteoporosis in daily life.
Total Laryngectomy in Advanced Papillary Thyroid Cancer Infiltrating into Larynx: A Case Report & review of Literature
Authors:   Department of Otorhinolaryngology-Head & Neck Surgery, Dr Ziauddin University & Hospital, Karachi, Pakistan, Molvi Ahad Yousaf , Ali Qandila ,   Department of Otorhinolaryngology-Head & Neck Surgery, Dr Ziauddin University & Hospital, Karachi, Pakistan., Pervaiz Ayesha ,   Department of Otorhinolaryngology-Head & Neck Surgery, Dr Ziauddin University & Hospital, Karachi, Pakistan., Naseem Muhammad Paras ,   Department of Otorhinolaryngology-Head & Neck Surgery, Dr Ziauddin University & Hospital, Karachi, Pakistan., Ikram Mubasher ,   Department of Otorhinolaryngology-Head & Neck Surgery, Dr Ziauddin University & Hospital, Karachi, Pakistan., Dhanani Rahim ,   Department of Otorhinolaryngology-Head & Neck Surgery, Dr Ziauddin University & Hospital, Karachi, Pakistan.
Published: April 2023

Abstract: Among differentiated thyroid cancer (DTC), papillary thyroid cancer (PTC) is the most commonly encountered histological type. Patients with papillary thyroid carcinoma (PTC) show an excellent prognosis. Infiltration of PTC into the larynx is very rare and can worsen the disease prognosis. We are reporting one such rare case in which PTC showed invasion in the larynx causing narrowing of the airway. We performed total thyroidectomy with total laryngectomy and neck dissection.
Klasifikasi Diabetes Mellitus Menggunakan Support Vector Machine (Studi Kasus: Puskesmas Modopuro, Mojokerto)
Authors: Cahyani Andharini Dwi , Basuki Ari
Published: April 2023

Diabetes Melitus (DM) merupakan salah satu penyakit dimana tubuh seorang pasien tidak dapat mengontrol tingkat konsentrasi gula (glukosa). Ada beberapa indikator kondisi tubuh pasien yang menunjukkan adanya penyakit diabetes. Pada penelitian ini dilakukan pengelompokan pasien DM dengan menggunakan metode Machine Learning. Algoritma yang digunakan adalah Support Vector Machine (SVM) yang merupakan metode klasifikasi supervised learning. SVM bekerja dengan membagi dataset menjadi 2 bagian dengan menggunakan garis linear (hyperplane) yang optimal. Target dari klasifikasi digunakan untuk memprediksi apakah pasien dengan indikator kondisi tubuh tertentu merupakan pasien DM yang terdeteksi atau tidak. Dari data yang diperoleh dari Puskesmas Modopuro, terdapat beberapa missing value. Pada penelitian ini, missing value diatasi dengan cara melakukan imputasi. Ada 3 kernel yang digunakan pada metode SVM, yaitu linear, polynomial, dan sigmoid. Pengukuran kinerja 3 jenis kernel tersebut akan menggunakan 5 subset cross validation. Nilai akurasi cross validation terbaik yang didapatkan menggunakan kernel linear, polynomial, dan sigmoid masing-masing yaitu 62%, 64%, dan 54%. Berdasarkan hasil pengamatan kernel polynomial mendapatkan hasil akurasi yang lebih baik dari kernel lainnya
Fahr’s syndrome secondary to hypoparathyroidism presenting with paralysis and recurrent seizures: a case report
Authors: Jihwaprani Muhammad Candragupta , Kumara Evan Gintang
Published: April 2023

Introduction:
Fahr’s syndrome (FS) is a rare neurodegenerative disorder characterized by bilateral and symmetrical calcification of basal ganglia and other brain structures. In contrast to Fahr’s disease, FS is distinguished by the association of secondary etiology. The diagnosis is confirmed by neuroimaging studies such as a head computer tomography (CT) scan or magnetic resonance imaging, which displays the calcification of basal ganglia and other structures in a bilateral and symmetrical pattern.
Case Report:
A 63-year-old female with a previous history of total thyroidectomy and ischemic stroke presented to our hospital with altered mentation and recurrent generalized tonic-clonic seizures. Laboratory evaluation revealed hypocalcemia, hypokalemia, and hypoparathyroidism. Imaging with head CT was consistent with FS, demonstrating bilateral, symmetrical, and extensive calcification of basal ganglia, corona radiata, and cerebellar hemispheres with ventricular enlargement.
Conclusion:
Our case represents a long-term consequence of untreated post-surgical hypoparathyroidism, which led to secondary FS. Long-term hypocalcemia and low calcium/phosphate ratio are associated with basal ganglia calcification in patients with hypoparathyroidism. Maintenance of eucalcemic and euphosphatemic state is essential as the preventive measure for metastatic calcification. There is currently no definitive treatment for FS, with adjunctive symptomatic treatments to reduce the clinical manifestations.
Variable cardiovascular risk factors is a risk factor for overall survival of patients with esophageal squamous cell carcinoma after surgery: a retrospective cohort study
Authors: Chen Sen , Ke Jiaxing , Lu Nan , Zhang Xueping , Hu Ende , Lin Xinmiao , Chen Haifeng
Published: April 2023

Background: Cardiovascular disease (CVD) and esophageal squamous cell carcinoma (ESCC) may share the same risk factors. The purpose of this study was to investigate the relationship between variable cardiovascular risk factors (CVRFs) and the prognosis of patients with ESCC.
Methods: This was a retrospective study that included 315 patients with stage II or III ESCC treated with radical surgery in Fujian Provincial Hospital from June 2015 to December 2018. According to the number of CVRFs, patients were divided into low-CVRFs group (number of CVRFs≤2) and high-CVRFs group (number of CVRFs>2). The observation endpoint was all-cause mortality. Follow-up was up to December 31, 2021. Kaplan-Meier method and COX regression analysis were used to perform survival analysis.
Results: The 315 patients were followed up for 1-78 months (median follow-up time 42 months). A total of 120 patients died by the follow-up date. The proportion of all-cause mortality was higher in the high-CVRFs group compared with the low-CVRFs group. Patients in the high-CVRFs group had a shorter survival time (p<0.05). After adjusting for conventional risk factors, diabetes, one of the CVRFs, was a risk factor for overall survival (OS) (HR 2.05, 95% CI 1.290-3.258, p=0.002). For each additional CVRF, the risk of all-cause mortality increases (HR 1.293, 95% CI 1.090-1.535, p=0.003). Similarly, among patients receiving chemotherapy or radiotherapy, there was an increased risk of all-cause mortality for each additional CVRF (HR 1.436, 95% CI 1.117-1.846, p=0.005 for chemotherapy; HR 1.761, 95% CI 1.335-2.322, p<0.001 for radiotherapy). Risk of all-cause mortality was higher in the high-CVRFs group compared to the low-CVRFs group (HR 1.636, 95% CI 1.101-2.431, p=0.015). High-CVRFs was a risk factor for OS in patients receiving chemotherapy or radiotherapy (HR 2.314, 95% CI 1.262-4.240, p=0.007 for chemotherapy; HR 3.336, 95% CI 1.781-6.251, p<0.001 for radiotherapy).
Conclusions: Diabetes, as one of the CVRFs, was an independent risk factor for OS in patients with stage II or III ESCC treated with radical surgery. CVRFs were associated with poorer OS, especially in those receiving radiotherapy or chemotherapy.
Health-Related Quality of Life and Radiological and Functional Lung Changes of Patients with Covid-19 Pneumonia 1 Year After Discharge
Authors: De Juana Cristina , Herrera Susana , Ponce Silvia , Calvache Sergio , Dahmazi Loubna , Vitale Raffaele , Ferrer Alberto José , Valentín Verónica , Acosta Marta , López Irene , Martínez-Moragón Eva
Published: April 2023

Background Few studies have evaluated the long-term impact on health-related quality of life (HRQoL) in patients who have been hospitalized for COVID-19 pneumonia. Specific follow-up should be carried out to detect and treat possible pulmonary abnormalities, and the worsening of HRQoL should be estimated to target necessary resources for care of these patients after acute phase. The objective was to know the impact on HRQoL of patients who have been admitted for COVID-19 pneumonia, and to evaluate the clinical-radiological and functional changes of patients who have overcome COVID19 pneumonia at 3 and 10 months of follow-up.Methods Prospective observational study of patients who required hospitalization for COVID-19 pneumonia between April and December 2020. All patients filled out the EuroQol five-dimension (EQ-5D) questionnaire with the EuroQol Visual Analogue Scale (E-VAS) for self-assessment of health status. Respiratory function tests and chest X-ray were carried out at 3 and 10 months of follow-up.Results 61 patients were included in the study. The need for ventilatory support was associated with anxiety / depression on the EQ-5D scale, as well as patients admitted to the intensive care unit (ICU). The mean EQ-5D and E-VAS index scores decreased with hospitalization time, the number of days spent in intermediate respiratory care unit (IRCU) and the level of dyspnoea at the beginning of the hospitalization period. Pulmonary sequelae were observed in 25 patients (41%) at 3 months and 17 (27.9%) at 10 months. Patients improve their forced vital capacity (FVC) by 196 ml (p = 0.001) at 10 months as well as 9% in diffusing capacity of lung for carbon monoxide (DLCO) (p = 0.001) at 10 months. DLCO was found to be correlated to lymphopenia and time spent in IRCU. Low FVC values were detected 10 months after discharge for subjects exhibiting high levels of dyspnoea at 3 months after discharge.Conclusions Hospitalization for COVID-19 pneumonia affects the HRQoL of patients, with greater anxiety / depression in those who were more serious affected and are younger. There is a significant percentage of patients who present fibrotic abnormalities and lung function impairment at the first and second follow-ups after discharge.
COVID-19 in Patients with Cancer: Insights from a Tertiary Care Intensive Care Unit
Authors: Shaikh Nissar , Wraidat Mohammad Al , Al-Assaf Anood A. , Al-Kaabi Salma K. , Abujaber Ahmad A. , Jasim Samar , Bujassoum Salha , Almaslamani Muna A. , Khatib Mohamad Y. , Yassin Mohamed A. , Nashwan Abdulqadir J.
Published: April 2023

Background & Aim: Since The emergence of the COVID-19, patients with cancer have been among the most vulnerable patients, as this infection can be severe and mostly requires intensive care therapy. Literature discussing the risk factors and the outcome of these patients in intensive care units (ICU) is accumulating. Our study aims to search for the incidence of COVID-19 infection in cancer patients and analyses their associated comorbidities, possible risk factor for infections, and their outcomes.
Methods: Patients with active cancer under treatment and those recently diagnosed with cancer and had confirmed COVID-19 infection requiring ICU admission were included in our study over 8 months, from March to October 2022. Patient demographic data, comorbidities, ICU stay, duration of hospital stay, oxygenation/ventilatory requirements, treatment, secondary bacterial infection, and outcome were collected from the COVID-19 patients' registry in the ICU. Data were entered into the SPSS program version 23, and results were considered statistically significant at p ≤ 0.05.
Results: A total of 24 patients with cancer and COVID-19 infection required intensive care therapy. The most common type of malignancy in those patients was solid organ tumor (13 vs. 11 patients), and most of the study sample were males (20/ 83.3%). Seventy-five percent (18 patients) required intubation and invasive ventilation. Twenty-nine percent (7 patients) had secondary bacterial pneumonia and bacteremia. In addition, 70% had septic shock and required vasopressors. Acute kidney injury (AKI) due to rhabdomyolysis (P<0.001), secondary bacterial infection (P<0.006), bacteremia and pneumonia (P<0.02), invasive ventilation (P<0.02) and requiring muscle relaxant (P<0.02), the requirement for High flow nasal cannula and prone position (P<0.03 and 0.01) respectively, shock (P<0.004) were significantly associated with increased mortality. Patients with cancer and COVID-19 had higher severity scores (P<0.003), longer ventilation duration (P<0.002), and ICU stay (P<0.002). Overall mortality was 45%.8, there was no significant difference in mortality rate between patients with solid organ tumors and hematological malignancy with COVID-19 infection requiring intensive care therapy (P<0.68).
Conclusion: Cancer patients requiring ICU were more prone to develop AKI, rhabdomyolysis, secondary infection, requiring ventilation and prone position, and septic shock. These patients had a significantly high mortality rate and were severely ill, requiring prolonged ventilation and ICU stays.
Filter cake enriched with rockdust on the morphometry of cherry tomato and malagueta pepper seedlings via multivariate modeling
Authors: Cunha Daíza Freire da , Silva Patrícia Costa , Costa Adriana Rodolfo da , Giongo Pedro Rogerio , Barbosa Kássia de Paula , Rodrigues Ádria Pereira , Silva Amanda de Brito , Neto José Veira Bessa , Parreira Júlio Cesar Leão , Silva Thanyewer Raiwer Leite , Montenegro Abelardo Antônio de Assunção , Pandorfi Héliton , Silva Jhon Lennon Bezerra da , Mesquita Marcio , Ferreira Maria Beatriz , de Sousa Lizandra de Barros , Macedo Rodrigo Santana , Refati Daiana Caroline , Silva Marcos Vinícius da
Published: April 2023

Brazil is one of the largest vegetable producers, which contributes to the creation of jobs for small and medium-sized producers, with emphasis on family farming. The objective of this work was to evaluate the cherry tomato and chili pepper seedlings development adopting the agroindustrial by-product filter cake enriched with rock dust. Two experiments were conducted, one with cherry tomatoes and the other with chili pepper in a greenhouse located at the State University of Goiás, Brazil. For each experiment, a randomized block design with six treatments and six replications was used, totaling 36 experimental plots. Each experimental plot comprised 8 tubes containing one plant in each, totaling 288 tubes and plants in each experiment. The treatments were formed by combining the agroindustrial by-product filter cake and rock dust. The total length of the seedling (TL), aboveground height (Ah.), stem diameter (SD), number of leaves (NL), root length (RL), fresh root mass (FRM), dry root mass (DRM) and dry aboveground mass (DAM) have been evaluated. The pepper and cherry tomato crops morphometric data was submitted to descriptive statistical analysis and principal component analysis (PCA). Only the 80% FC + 20% RD treatment, which did not have a high coefficient of variation (CV) for the plant morphometric variables, characterizing the most efficient treatment for the seedlings morphometric development. It was verified that higher proportions of filter cake (treatment at 100% and 90% of the cake application) resulted in greater variability of the growth and development of pepper seedlings. It was also found that there is a high correlation between RL and TL, with correlation coefficients close to 1. Such behaviour occurred as a result of the co-dependency of these crop systems. The 80% FC + 20% RD treatment showed the best results for the morphometric development of chili pepper and cherry tomato seedlings, which should be recommended for future experiments, as well as to be adopted by small producers.
Agro-morphological traits and iPBS-ISSR markers based genetic characterization of flax genotypes (Linum usitatissimum L.)
Authors: KOCAK Mehmet Zeki , Kaysim Mustafa Guven , Aydın Adnan , Erdinc Ceknas , Kulak Muhittin
Published: April 2023

Flax is one of the significant crops owing to oilseed and fibre attributes, exhibiting a wide distribution in many parts of the world. The present study was designed to reveal the genetic diversity of 29 genotypes of flax through morphological traits and 12 iPBS and 33 ISSR markers. According to the UPGMA-based dendogram, genotypes of the flax were classified into the two major groups (A and B) and group B was composed of two sub-groups (B1 and B2) according to the six phenotypic attributes considered for analysis. Concerning molecular relationships of the genotypes, individual and combined UPGMA-based dendograms were constructed with respect to the ISSR and iPBS markers. According to the Jaccard similarity coefficients for ISSR data, flax genotypes were divided into two main groups (A and B) and the “Van-1” genotype was in group A alone. Also, group B was divided into two separate subgroups. “Afyon-1” and “İzmir-Kemeraltı” genotypes were located in group B1, while all the remaining genotypes were located in group B2. In addition, the average genetic similarity was 0.755 regarding the findings of iPBS-retrotsposon markers, flax genotypes were classified into two main groups (A and B), and these main groups formed two subgroups among themselves. While “Konya-1” is located alone in A1 subgroup, “Iğdır”, “İzmir-Kemeraltı”, “Mardin”, “Bitlis” and “Afyon-1” genotypes are located in A2 subgroup. While “Van-1” genotype was located in the B2 subgroup alone, other genotypes were found in the B2 subgroup. The average genetic similarity was determined as 0.578 according to Jaccard binary similarity coefficient. According to the combined data of two markers, two separate groups (A and B) were revealed, similar to the dendrogram constructed with ISSR data. “Van-1” genotype was located in group A alone. Group B was divided into two subgroups (B1 and B2). The average genetic similarity was 0.722 according to the Jaccard similarity coefficient of matrix.
Assessment of Tree Diversity of Riparian Forest Fragments in Omo Biosphere Reserve, Ogun State, Nigeria
Authors: Olatidoye Olatidoye O. R. , Isichei Isichei A. O. , OYELOWO OYELOWO O.J. , Koyejo Koyejo O. A. , Kambi Kambi C. , Jeminiwa Jeminiwa O.R.
Published: April 2023

Frequently discontinuous landscapes are attributed to various unsustainable human activities all over the world. These activities result to poorer diversity and reduced quite a lot of landscape The study was laid out on various sites of the stratified zone of the reserve namely: Core, Buffer and Transition. Riparian forests along Major River and Streams were sampled. Ninety plots (25m × 25m) were selected for the study. Sites were chosen based on accessibility within the zones and it was ensured that a variety of physiognomy were well represented. In all, 74 tree species, 31 families 65 genera were identified. Shannon index varied from 2.17 to 3.036, evenness of the riparian tree species was 0.056 and Sorensen index was 90.5%. The Core zone of the reserve has the highest occurrence of riparian and upland tree species in comparison with the buffer and transition zone. Diospyros dendo is the most occurring species in the core zone and more species were found along major rivers. In the buffer zone, tree species along the stream had higher representation with Cleistopholis patens observed while in the transition zone, higher diversity was found in species along the major rivers with Theobroma cacao having the highest occurrence. This study shows that the composition and plant community structure is affected by a range of disorders such as frequencies and magnitude of human activities at different levels. Species along streams had higher abundance than those along Major Rivers due to low intensity in the rate of flow of water which enables inundation and support of seed settlement for germination.
A Multi-Perspective Study of Discourse Markers: An Attempt to Sort out the Muddle among EFL Teachers-Students
Authors: Azeez Abbas Ibrahim , Mahmoud Ayad Hameed , Nouri Ahmed Adel
Published: April 2023

This study aims at sorting out the confusion among EFL teachers caused by the feature of multi-functionality ascribed to Discourse Markers, by studying them pragmatically from various perspectives. The study hypothesizes that the multifunctional aspect attributed to Discourse Markers resides in the social and situational factors in which they are used such as the gender of the speakers, the relationship between them, the topic they talk about, and its theme. It also hypothesizes that females and males are strategically different in terms of using discourse markers, which brings about the multifunctional feature of discourse markers. The results of the analysis show that males and females use the same Discourse Markers for different purposes. The type of topic has an impact on the participants to use a particular Discourse Marker over the other types. Participants who are in a solidary or symmetrical relationship employ Discourse Markers differently from other participants who are in an asymmetrical relationship. Participants arrange their speech according to the goal they want to reach and they subjectively use DMs accordingly. The general theme, which covers the entire discourse, guides the participants to use particular types of Discourse Markers that address its requirements. The capacity of Discourse Markers is generated by means of being semantically bleaching which leads them to serve more than one function.
Learning Writing Skill During Covid-19 Pandemic through E-Learning in Indonesian English Classroom
Authors: Rizal Muhammad
Published: April 2023

The objectives of this research were to find out the kinds of E-learning used during the learning writing skill in the Fourth Semester of IAIN Samarinda and to find out the students’ perception of English Department Students in the Fourth Semester of IAIN Samarinda in learning writing skill through E-learning. The design of this research was quantitative research. The researcher analyzed the data by using rate percentage and mean score. The instrument used in this research was a questionnaire. The researcher used a close-ended questionnaire to gather the data. The researcher used “Yes/No” questions for 11 questions and “5-Likert Scales” for seven questions. In this research, the questionnaire’s link was distributed via WhatsApp group. The population and sample of this research were English Department Students in the Fourth Semester of IAIN Samarinda. There were 94 students in this research. Based on the results of this research, the researcher found that the most used kind of E-learning utilized by English Department Students in the Fourth Semester of IAIN Samarinda in learning writing skills during the COVID-19 Pandemic was Mobile Learning. The data showed that in Mobile Learning, 94 students, or 100% used smartphones, 81 students, and 86,2% used laptops. Based on the findings, the mean of students’ perception was 23,11. It can be concluded that students’ perception of learning writing skills through E-learning was categorized into a very bad category.
The Types of Lecturers’ Feedback on EFL Learners’ Writing
Authors: Mulyani Suci
Published: April 2023

Feedback is very essential in learning. It can help students to get the bigger picture of their progress, which stage they are in, and what steps they are going to take for future learning.  Giving feedback is considered to be the essential role of a teacher or lecturer in guiding students in their learning process. As many experts noted that writing is the most complex skill to learn, and students need more assistance in developing their writing. Here, teachers or lecturers are needed to guide them in the whole process of writing, which are pre-writing, drafting, revising, and editing. Considering this prominent role of giving feedback, it is necessary for teachers or lecturers, and also the students to know about the types of feedback used in English writing. This will be useful for the teachers or lecturers to understand what type of feedback they will use in the learning, and for the students to reflect more on their preference for the given feedback.