bluuebunny/crossref_metadata_2025 huggingface dataset:
Spreading of Information on a Network: A Quantum View
Authors: Bagarello Fabio , Gargano Francesco , Gorgone Matteo , Oliveri Francesco
Published: October 2023

This paper concerns the modeling of the spread of information through a complex, multi-layered network, where the information is transferred from an initial transmitter to a final receiver. The mathematical model is deduced within the framework of operatorial methods, according to the formal mathematical apparatus typical of quantum mechanics. Two different approaches are considered: one based on the (H,ρ)-induced dynamics and one on the Gorini–Kossakowski–Sudarshan–Lindblad (GKSL) equation. For each method, numerical results are presented.
Autonomous Scheduling for Reliable Transmissions in Industrial Wireless Sensor Networks
Authors: Darbandi Armaghan , Kim Myung-Kyun
Published: October 2023

Deploying Internet of Things (IoT) on low-power lossy wireless sensor/actuator networks (LLN) in harsh industrial environments presents challenges such as dynamic link qualities due to noise, signal attenuations and spurious interferences. However, the critical demand for industrial applications is reliability of data delivery on low-cost low-power sensor/actuator devices. To address these issues, this paper proposes a fully autonomous scheduling approach, called Auto-Sched, which ensures reliability of data delivery for both downlink and uplink traffic scheduling and enhances network robustness against node/link failures. To ensure reliability, Auto-Sched assigns retransmission time slots based on the reliability constraints of the communication link. To avoid collision issues, Auto-Sched creates an upward pipeline-like communication schedule for uplink end-to-end data delivery, and a downward pipeline-like communication schedule for downlink scheduling. For enhancing network robustness, we propose a simple algorithm for real-time autonomous schedule reconstruction, when node or link failures occur, with minimal influence on communication overhead. Performance evaluations quantified the performance of our proposed approaches under a variety of scenarios comparing them with existing approaches.
Numerical and Techno-Economic Analysis of Batch Annealing Performance Improvements in Tinplate Manufacturing
Authors: Schoina L. , Jones R. , Burgess S. , Vaughan D. , Andrews L. , Foley A. , Valera Medina A.
Published: October 2023

The present study examines the performance improvement in the batch annealing process used in tinplate manufacturing by enhancing the heat transfer towards the steel coils and altering annealing cycle parameters. Presently, the heat transfer in the furnace is non-uniform, resulting in non-uniform temperature profiles and recrystallisation inside the coils, affecting the final coated steel quality. This study modelled a current furnace and four improvement proposals utilising transient computational fluid dynamics, to produce coil temperature profiles and rank the cases by the highest coil temperature uniformity achieved at the end of soaking. By increasing the soaking temperature and time, as well as the coiling tension before annealing and altering the coil size, the aim was to achieve higher and more uniform coil temperatures that could ensure successful recrystallisation with less defects, especially at the cold spot area in the middle of the coil. Then, a techno-economic analysis compared the cost-effectiveness of the scenarios based on the associated costs and the improvement in the scratching defects of the batch-annealed steel. Overall, most cases exhibited positive results regarding temperature uniformity enhancement, but increasing the coiling tension was considered the most promising option, due to the combination of a large defect reduction potential and cost savings per cycle.
Fire Affects Tree Growth, Water Use Efficiency and Carbon Sequestration Ecosystem Service of Pinus nigra Arnold: A Combined Satellite and Ground-Based Study in Central Italy
Authors: Niccoli Francesco , Altieri Simona , Kabala Jerzy Piotr , Battipaglia Giovanna
Published: October 2023

The Mediterranean basin is an area particularly exposed to fire risk due to its climate and fire-prone vegetation. In recent decades, the frequency and intensity of wildfires increased, leading to negative effects on forests, such as a decrease in tree growth or an increase in tree mortality, producing a relevant loss of carbon sequestration ecosystem service. This study of the impacts of fires on forests is fundamental for planning adequate forest management strategies aimed at recovering and restoring the affected areas. In this framework, our research delves into the effects of a forest fire that, in 2017, affected a forest of black pine (Pinus nigra Arnold) in Central Italy. Combining satellite and terrestrial analyses, this study evaluated the impact of the fire on tree growth, water use efficiency and carbon sequestration capacity. Our findings highlight the importance of using remote sensing for the accurate identification of fire-affected areas and precise planning of ground-based activities. However, the integration of satellite data with forest surveys and sampling has proven crucial for a detailed understanding of fire’s effects on trees. Dendrochronology and stable isotopes have revealed the post-fire growth decline and altered water usage of defoliated trees. Furthermore, the quantification of CO2 sequestration highlighted a significant reduction in carbon uptake by damaged trees, with severe implications for this ecosystem service.
Comparison of Supervised Learning Algorithms on a 5G Dataset Reduced via Principal Component Analysis (PCA)
Authors: Gonzalez-Franco Joan D. , Preciado-Velasco Jorge E. , Lozano-Rizk Jose E. , Rivera-Rodriguez Raul , Torres-Rodriguez Jorge , Alonso-Arevalo Miguel A.
Published: October 2023

Improving the quality of service (QoS) and meeting service level agreements (SLAs) are critical objectives in next-generation networks. This article presents a study on applying supervised learning (SL) algorithms in a 5G/B5G service dataset after being subjected to a principal component analysis (PCA). The study objective is to evaluate if the reduction of the dimensionality of the dataset via PCA affects the predictive capacity of the SL algorithms. A machine learning (ML) scheme proposed in a previous article used the same algorithms and parameters, which allows for a fair comparison with the results obtained in this work. We searched the best hyperparameters for each SL algorithm, and the simulation results indicate that the support vector machine (SVM) algorithm obtained a precision of 98% and a F1 score of 98.1%. We concluded that the findings of this study hold significance for research in the field of next-generation networks, which involve a wide range of input parameters and can benefit from the application of principal component analysis (PCA) on the performance of QoS and maintaining the SLA.
Prevalence of Coagulopathy in Patients with Celiac Disease: A Single-Center Retrospective Case-Control Study
Authors: Balaban Daniel Vasile , Coman Laura Ioana , Enache Iulia Cristina , Mardan Cristian Mihail , Dima Alina , Jurcuț Ciprian , Balaban Marina , Costache Raluca Simona , Ioniță-Radu Florentina , Popp Alina , Jinga Mariana
Published: October 2023

Introduction: Despite being one of the most frequent chronic digestive diseases worldwide, with a prevalence of 1%, celiac disease (CD) remains severely underdiagnosed. Among the instruments used to improve its diagnostic rate, hematologic parameters have been proposed as screening tests to select patients with an increased probability of having CD. Assessment of coagulation is included in routine check-ups, and CD has been reported to be associated with coagulopathy. We aimed to assess if subtle changes in coagulation tests could be used in clinical practice to prompt testing for CD. Methods: We retrospectively recruited all patients with clinical suspicion for CD during a study period of 7 years (between 2015 and 2022), who were tested using IgA tissue transglutaminase (tTG) serology and serum total IgA (IgG tTG in case of IgA deficiency) and who underwent upper gastrointestinal endoscopy with multiple biopsy sampling of the duodenal bulb and distal duodenum. We stratified patients into three groups: newly diagnosed CD, gluten-free diet-treated CD, and non-CD controls. Results: Altogether, there were 133 CD patients (71 newly diagnosed, 62 GFD-treated) and 57 non-CD controls. Mean age and gender distribution were similar among the three groups: 43.3 years for newly diagnosed CD, 41.6 years for non-CD controls, and 44 years for GFD-treated CD patients, with a male gender distribution of 21.1%, 28%, and 24.1%, respectively. Among the included newly diagnosed CD patients, 14% had a prolonged INR. The mean INR was slightly higher in newly diagnosed CD patients, compared to GFD-treated CD patients and non-CD controls: 1.12 ± 0.30, 1.02 ± 0.83, and 1.00 ± 0.08, respectively (p = 0.009). Consequently, prothrombin activity was slightly lower in newly diagnosed CD patients, compared to GFD-treated CD and non-CD controls: 94.9 ± 19.3%, 102.3 ± 12.8%, and 101.9 ± 15.15, respectively. Interestingly, after GFD, the mean INR and prothrombin activity of CD individuals reached a value similar to that of non-CD controls. Conclusions: Subtle changes in INR, defined as a value within the normal range, but closer to the upper limit, could be an indicator of probability for CD.
Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences
Authors: Finotti Alessia , Gasparello Jessica , Zuccato Cristina , Cosenza Lucia Carmela , Fabbri Enrica , Bianchi Nicoletta , Gambari Roberto
Published: October 2023

The anticancer drug mithramycin (MTH), has been proposed for drug repurposing after the finding that it is a potent inducer of fetal hemoglobin (HbF) production in erythroid precursor cells (ErPCs) from β-thalassemia patients. In this respect, previously published studies indicate that MTH is very active in inducing increased expression of γ-globin genes in erythroid cells. This is clinically relevant, as it is firmly established that HbF induction is a valuable approach for the therapy of β-thalassemia and for ameliorating the clinical parameters of sickle-cell disease (SCD). Therefore, the identification of MTH biochemical/molecular targets is of great interest. This study is inspired by recent robust evidence indicating that the expression of γ-globin genes is controlled in adult erythroid cells by different transcriptional repressors, including Oct4, MYB, BCL11A, Sp1, KLF3 and others. Among these, BCL11A is very important. In the present paper we report evidence indicating that alterations of BCL11A gene expression and biological functions occur during MTH-mediated erythroid differentiation. Our study demonstrates that one of the mechanisms of action of MTH is a down-regulation of the transcription of the BCL11A gene, while a second mechanism of action is the inhibition of the molecular interactions between the BCL11A complex and specific sequences of the γ-globin gene promoter.
Transfer of Bisphenol A and Trace Metals from Plastic Packaging to Mineral Water in Ouagadougou, Burkina Faso
Authors: Sawadogo Boukary , Konaté Francis Ousmane , Konaté Yacouba , Traoré Ousmane , Sossou Seyram Kossi , Sawadogo Eric , Sourabié Ouattara Pane Bernadette , Karambiri Harouna
Published: October 2023

The consumption of packaged water is growing rapidly in both urban and rural centres in Burkina Faso. Bisphenol A (BPA) and trace metals are among the compounds used in the manufacture of plastic packaging, and their presence in water can pose a health risk to consumers due to their alleged toxicity. Therefore, this study explores the transfer of these compounds from plastic packaging to mineral water in Sudano-Sahelian climatic conditions. Ten samples of packaged sachet water commercialised in Ouagadougou were studied. An absence of BPA in the borehole water used to produce packaged water has been shown. The transfer of BPA into mineral water increases with storage temperature. The BPA that appears in packaged water degrades over time. BPA concentrations ranged from 0 to 0.38 mg/L after two weeks of storage, 0 to 0.8 mg/L after four weeks of storage and 0 to 0.35 mg/L after 8 weeks of storage. Analysis of the trace metals showed steadily increasing concentrations from the second to the sixth weeks, with concentrations ranging from 0 to 9.7 µg/L for cadmium and from 0 to 0.13 mg/L for iron in the sachet water samples.
Protective Effect of Mycosporine-like Amino Acids Isolated from an Antarctic Diatom on UVB-Induced Skin Damage
Authors: Wang Kai , Deng Yashan , He Yingying , Cao Junhan , Zhang Liping , Qin Ling , Qu Changfeng , Li Hongmei , Miao Jinlai
Published: October 2023

Although it is well recognized that mycosporine-like amino acids (MAAs) are ultraviolet (UV) protective agents that can reduce UV damage, the specific biological mechanism of its role in the skin remains unclear. In this study, we investigated the effect of MAAs extracted from Antarctic diatom Phaeodactylum tricornutum ICE-H on UVB-induced skin damage using a mice model. The MAAs components identified by liquid chromatography-tandem mass spectrometry included 4-deoxygadusol, shinorine, and porphyra-334, which were purified using a Supledean Carboxen1000 solid phase extraction column. The antioxidant activities of these MAA compounds were tested in vitro. For UVB-induced skin photodamage in mice, MAAs alleviated skin swelling and epidermal thickening in this study. We detected the content of reactive oxygen species (ROS), malondialdehyde, and collagen in skin tissue. In addition, quantitative real-time polymerase chain reaction was used to detect nuclear factor-κB (NF-κB), tumor necrosis factor α, interleukin-1β, cyclooxygenase-2, mitogen activated protein kinase (MAPK) family (extracellular signal-regulated kinase, c-Jun amino-terminal kinase, and p38 kinase), and matrix metalloproteinases. The expression of these cytokines and enzymes is related to inflammatory responses and collagen degradation. In comparison to the model group without MAA treatment, the MAA component decreased the concentration of ROS, the degree of oxidative stress in the skin tissue, and the expression of genes involved in the NF-κB and MAPK pathways. In summary, these MAA components extracted from Phaeodactylum tricornutum ICE-H protected against UVB-induced skin damage by inhibiting ROS generation, relieving skin inflammation, and slowing down collagen degradation, suggesting that these MAA components are effective cosmetic candidate molecules for the protection and therapy of UVB damage.
Anisomeles indica Extracts and Their Constituents Suppress the Protein Expression of ACE2 and TMPRSS2 In Vivo and In Vitro
Authors: Chen Yu-Ru , Jiang Wen-Ping , Deng Jeng-Shyan , Chou Ya-Ni , Wu Yeh-Bin , Liang Hui-Ju , Lin Jaung-Geng , Huang Guan-Jhong
Published: October 2023

Coronavirus disease 2019 (COVID-19), stemming from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a profound global impact. This highly contagious pneumonia remains a significant ongoing threat. Uncertainties persist about the virus’s effects on human health, underscoring the need for treatments and prevention. Current research highlights angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) as key targets against SARS-CoV-2. The virus relies on ACE2 to enter cells and TMPRSS2 to activate its spike protein. Inhibiting ACE2 and TMPRSS2 expression can help prevent and treat SARS-CoV-2 infections. Anisomeles indica (L.) Kuntze, a medicinal plant in traditional Chinese medicine, shows various promising pharmacological properties. In this study, ethanolic extracts of A. indica were examined both in vivo (250 and 500 μM) and in vitro (500 μM). Through Western blotting analysis, a significant reduction in the expression levels of ACE2 and TMPRSS2 proteins was observed in HepG2 (human hepatocellular carcinoma) cells and HEK 293T (human embryonic kidney) cell lines without inducing cellular damage. The principal constituents of A. indica, namely, ovatodiolide (5 and 10 μM), anisomlic acid (5 and 10 μM), and apigenin (12.5 and 25 μM), were also found to produce the same effect. Furthermore, immunohistochemical analysis of mouse liver, kidney, and lung tissues demonstrated a decrease in ACE2 and TMPRSS2 protein expression levels. Consequently, this article suggests that A. indica and its constituents have the potential to reduce ACE2 and TMPRSS2 protein expression levels, thus aiding in the prevention of SARS-CoV-2 infections.
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Sudden Infant Death Syndrome: A Potential Model for Investigation
Authors: Tóth Dénes , Simon Gábor , Reglődi Dóra
Published: October 2023

Sudden infant death syndrome (SIDS) represents a significant cause of post-neonatal mortality, yet its underlying mechanisms remain unclear. The triple-risk model of SIDS proposes that intrinsic vulnerability, exogenous triggers, and a critical developmental period are required for SIDS to occur. Although case–control studies have identified potential risk factors, no in vivo model fully reflects the complexities observed in human studies. Pituitary adenylate cyclase-activating polypeptide (PACAP), a highly conserved neuropeptide with diverse physiological functions, including metabolic and thermal regulation, cardiovascular adaptation, breathing control, stress responses, sleep–wake regulation and immunohomeostasis, has been subject to early animal studies, which revealed that the absence of PACAP or its specific receptor (PAC1 receptor: PAC1R) correlates with increased neonatal mortality similar to the susceptible period for SIDS in humans. Recent human investigations have further implicated PACAP and PAC1R genes as plausible contributors to the pathomechanism of SIDS. This mini-review comprehensively synthesizes all PACAP-related research from the perspective of SIDS and proposes that PACAP deficiency might offer a promising avenue for studying SIDS.
The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis
Authors: Xu Long , Yan Xiaoyu , Wang Jian , Zhao Yuanxin , Liu Qingqing , Fu Jiaying , Shi Xinyi , Su Jing
Published: October 2023

Ovarian cancer is the most lethal gynecologic malignancy, and metastasis is the major cause of death in patients with ovarian cancer, which is regulated by the coordinated interplay of genetic and epigenetic mechanisms. Histone deacetylases (HDACs) are enzymes that can catalyze the deacetylation of histone and some non-histone proteins and that are involved in the regulation of a variety of biological processes via the regulation of gene transcription and the functions of non-histone proteins such as transcription factors and enzymes. Aberrant expressions of HDACs are common in ovarian cancer. Many studies have found that HDACs are involved in regulating a variety of events associated with ovarian cancer metastasis, including cell migration, invasion, and the epithelial–mesenchymal transformation. Herein, we provide a brief overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. In addition, we discuss the roles of HDACs in the regulation of ovarian cancer metastasis. Finally, we discuss the development of compounds that target HDACs and highlight their importance in the future of ovarian cancer therapy.
Rhodamine-Based Cyclic Hydroxamate as Fluorescent pH Probe for Imaging of Lysosomes
Authors: Kim Young Ju , Jang Mina , Roh Jongtae , Lee Yoon Jeong , Moon Hee Jung , Byun Jimin , Wi Jihyun , Ko Sung-Kyun , Tae Jinsung
Published: October 2023

Monitoring the microenvironment within specific cellular regions is crucial for a comprehensive understanding of life events. Fluorescent probes working in different ranges of pH regions have been developed for the local imaging of different pH environments. Especially, rhodamine-based fluorescent pH probes have been of great interest due to their ON/OFF fluorescence depending on the spirolactam ring’s opening/closure. By introducing the N-alkyl-hydroxamic acid instead of the alkyl amines in the spirolactam of rhodamine, we were able to tune the pH range where the ring opening and closing of the spirolactam occurs. This six-membered cyclic hydroxamate spirolactam ring of rhodamine B proved to be highly fluorescent in acidic pH environments. In addition, we could monitor pH changes of lysosomes in live cells and zebrafish.
Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression
Authors: Quintero Juan Carlos , Díaz Néstor Fabián , Rodríguez-Dorantes Mauricio , Camacho-Arroyo Ignacio
Published: October 2023

Cancer stem cells exhibit self-renewal, tumorigenesis, and a high differentiation potential. These cells have been detected in every type of cancer, and different signaling pathways can regulate their maintenance and proliferation. Androgen receptor signaling plays a relevant role in the pathophysiology of prostate cancer, promoting cell growth and differentiation processes. However, in the case of prostate cancer stem cells, the androgen receptor negatively regulates their maintenance and self-renewal. On the other hand, there is evidence that androgen receptor activity positively regulates the generation of cancer stem cells in other types of neoplasia, such as breast cancer or glioblastoma. Thus, the androgen receptor role in cancer stem cells depends on the cellular context. We aimed to analyze androgen receptor signaling in the maintenance and self-renewal of different types of cancer stem cells and its action on the expression of transcription factors and surface markers associated with stemness.
Exploring Factors Affecting Mobile Government Services Adoption in the Egyptian Context
Authors: Elbatanouny Sherif , Dafoulas Georgios , Saleeb Noha
Published: October 2023

This research intends to identify factors in the adoption of mobile government services, recognizing the main mobile government acceptance factors through different models, namely, the theory of reasoned action (TRA), the theory of planned behavior (TPB), the technology acceptance model (TAM), the technology readiness index (TRI), and the unified theory of acceptance and use of technology (UTAUT). Reviewing prior studies on factors that influence mobile government acceptance in Egypt and addressing local challenges help in the development of effective strategies for successful implementation, considering opportunities and challenges in value-added services (VAS). Therefore, the main objectives of this paper are as follows: we critically review prior studies to identify the main mobile government acceptance factors, explore the identified dimensions of mobile government acceptance, and recognize further insights into the challenges that exist in the Egyptian context. Data are gathered through interviews with technology experts and customers with technological experience in Egypt. The findings of the study show that the factors affecting mobile government adoption in the Egyptian context are identified as follows: facilitating conditions, opportunities and challenges, technology and information systems, perceived usefulness, challenges like a lack of trust, cost, privacy, age, and several other obstacles. This research assists scholars and practitioners with insights into how to create and promote an application that is deemed attractive for the adoption of m-government services.
Effect of A- or B-Site Sc Doping on Sintering Temperature, Crystal Structure, Microstructure, and Properties of BaZrxTi1−xO3 Ceramics
Authors: Zhang Kaituo , Li Tiantian , Xu Yuan
Published: October 2023

BaZrxTi1−xO3 (BZT) ceramics with different concentrations of Sc ions were prepared, and the effect of doping concentration on the crystal substitution type of BZT was studied. The substitution position of the Sc ion in BZT was related to its concentration. When the concentration of Sc ions was low (<1.0 mol %), it showed B-site substitution; otherwise, Sc ions showed A-site substitution. In addition, the effects of the Sc ion concentration on the sintering temperature, crystal structure, microstructure, and properties of BZT were also studied. The results showed that the introduction of Sc ions can reduce the sintering temperature to 1250 °C. When the concentration of Sc ions was 1.0 mol % and 2.0 mol %, the high dielectric constants of BZT were 14,273 and 12,747, respectively.
MOF-Derived Spindle-Shaped Z-Scheme ZnO/ZnFe2O4 Heterojunction: A Magnetic Recovery Catalyst for Efficient Photothermal Degradation of Tetracycline Hydrochloride
Authors: Suo Shilong , Ma Wenmei , Zhang Siyi , Han Ziwu , Wang Yumin , Li Yuanyuan , Xiong Yi , Liu Yong , He Chunqing , Fang Pengfei
Published: October 2023

The development of photocatalysts with a wide spectral response and effective carrier separation capability is essential for the green degradation of tetracycline hydrochloride. In this study, a magnetic recyclable Z-scheme ZnO/ZnFe2O4 heterojunction (ZZF) was successfully constructed via the solid phase method, using MIL-88A(Fe)@Zn as the precursor. An appropriate band gap width and Z-scheme charge transfer mechanism provide ZZF with excellent visible light absorption performance, efficient charge separation, and a strong redox ability. Under visible light irradiation, the degradation efficiency of tetracycline hydrochloride for the optimal sample can reach 86.3% within 75 min in deionized water and 92.9% within 60 min in tap water, exhibiting superior stability and reusability after five cycles. Moreover, the catalyst in the water can be conveniently recovered by magnetic force. After visible light irradiation for 70 min, the temperature of the reaction system increased by 21.9 °C. Its degradation constant (35.53 × 10−3 min−1) increased to 5.1 times that at room temperature (6.95 × 10−3 min−1). Using thermal energy enhances the kinetic driving force of the reactants and facilitates carrier migration, meaning that more charge is available for the production of •O2− and •OH. This study provides a potential candidate for the efficient degradation of tetracycline hydrochloride by combining thermal catalysis with a photocatalytic heterojunction.
Application of Laser-Induced Breakdown Spectroscopy for Depth Profiling of Multilayer and Graded Materials
Authors: Królicka Agnieszka , Maj Anna , Łój Grzegorz
Published: October 2023

Laser-induced breakdown spectroscopy (LIBS) has emerged as a powerful analytical method for the elemental mapping and depth profiling of many materials. This review offers insight into the contemporary applications of LIBS for the depth profiling of materials whose elemental composition changes either abruptly (multilayered materials) or continuously (functionally graded or corroded materials). The spectrum of materials is discussed, spanning from laboratory-synthesized model materials to real-world products including materials for fusion reactors, photovoltaic cells, ceramic and galvanic coatings, lithium batteries, historical and archaeological artifacts, and polymeric materials. The nuances of ablation conditions and the resulting crater morphologies, which are instrumental in depth-related studies, are discussed in detail. The challenges of calibration and quantitative profiling using LIBS are also addressed. Finally, the possible directions of the evolution of LIBS applications are commented on.
Small Specimen Technology for Revealing Mechanical Properties of Alloys, 3D-Printing Metals and Welding Joints
Authors: Peng Jian
Published: October 2023

Small specimen technologies, such as the small punch test, the indentation test, and the in situ Scanning Electron Microscope (SEM)/Electron Back Scatter Diffraction (EBSD) test, provide important data support for understanding mechanical properties when the size of testing materials is limited, such as for alloys, 3D printing metals, and welding joints, as illustrated in Figure 1 [...]
The Fabrication of Halogen-Doped FeWO4 Heterostructure Anchored over Graphene Oxide Nanosheets for the Sunlight-Driven Photocatalytic Degradation of Methylene Blue Dye
Authors: Irfan Muhammad , Tahir Noor , Zahid Muhammad , Noreen Saima , Yaseen Muhammad , Shahbaz Muhammad , Mustafa Ghulam , Shakoor Rana Abdul , Shahid Imran
Published: October 2023

Rapid industrialization and urbanization are the two significant issues causing environmental pollution. The polluted water from various industries contains refractory organic materials such as dyes. Heterogeneous photocatalysis using semiconductor metal oxides is an effective remediation technique for wastewater treatment. In this research, we used a co-precipitation-assisted hydrothermal method to synthesize a novel I-FeWO4/GO sunlight-active nanocomposite. Introducing dopant reductive iodine species improved the catalytic activity of FeWO4/GO. I− ions improved the catalytic performance of H2O2 by doping into FeWO4/GO composite. Due to I− doping and the introduction of graphene as a support medium, enhanced charge separation and transfer were observed, which is crucial for efficient heterogeneous surface reactions. Various techniques, like FTIR, SEM-EDX, XRD, and UV–Vis spectroscopy, were used to characterize composites. The Tauc plot method was used to calculate pristine and iodine-doped FeWO4/GO bandgap. Iodine doping reduced the bandgap from 2.8 eV to 2.6 eV. The degradation of methylene blue (MB) was evaluated by optimizing various parameters like catalyst concentration, oxidant dose, pH, and time. The optimum conditions for photocatalysts where maximum degradation occurred were pH = 7 for both FeWO4/GO and I-FeWO4/GO; oxidant dose = 9 mM and 7 mM for FeWO4/GO and I-FeWO4/GO; and catalyst concentration = 30 mg and 35 mg/100 mL for FeWO4/GO and I-FeWO4/GO; the optimum time was 120 min. Under these optimum conditions, FeWO4/GO and I-FeWO4/GO showed 92.0% and 97.0% degradation of MB dye.
Comparative Analysis of the Wood Metabolites of Three Poplar Clones Using UPLC-Triple-TOF-MS
Authors: Li Liping , Liu Yun , Yu Xiaorui , Yang Xiaoqin , Xie Sida , Zhu Guolei , Zhao Ping
Published: October 2023

Poplar, a woody tree species, is widely used for industrial production and as a protective forest belt. Different clones of poplar exhibit clear variation in terms of morphological and physiological features, however, the impact of the genetic variation on the composition and abundance of wood metabolite have not been fully determined. In this study, ultra-high pressure liquid chromatography-triple time of flight-mass spectrometer (UPLC-Triple-TOF-MS) was used to explore the metabolite changes in poplar wood from three clones, including Populus deltoides CL. ‘55/65’, P. deltoides CL. ‘Danhong’, and P. nigra CL. ‘N179’. A total of 699 metabolites were identified. Clustering analysis and principal component analysis display that the metabolic differences of wood have allowed distinguishing different species of poplar. Meanwhile, eight significantly different metabolites were screened between P. deltoides and P. nigra, which may be considered as valuable markers for chemotaxonomy. In addition, the highly discriminant 352 metabolites were obtained among the three clones, and those may be closely related to the distinction in unique properties (e.g., growth, rigidity and tolerance) of the poplar wood cultivars. This study provides a foundation for further studies on wood metabolomics in poplar, and offers chemotaxonomic markers that will stimulate the early screening of potentially superior trees.
Management of Exciton Distribution for High-Performance Organic Light-Emitting Diodes Based on Interfacial Exciplex Architecture
Authors: Sheng Ren , Chen Cong , Zhang Erdong , Zhao Wencheng , Tang Jihua , Yan Duxu , Li Zhengze , Chen Ping
Published: October 2023

Interfacial exciplex has recently been adopted as an effective host to achieve phosphorescent organic light-emitting diodes (OLEDs) with high efficiencies and low driving voltages. However, a systematic understanding of exciton recombination behavior in either host of interfacial exciplex is still deficient. Herein, the strategic design rule of interfacial exciplex host is proposed to overcome the negative effects of direct trapping recombination by systematically investigating exciton recombination behavior in interfacial exciplex hosts. As a result, blue and orange phosphorescent devices acquire peak external quantum efficiencies of 23.5% and 29.2% with low turn-on voltages. These results provide a simple method to realize highly efficient OLEDs aiming for general lighting and display applications.
Effect of Germinated Sorghum Extract on the Physical and Thermal Properties of Pre-Gelatinized Cereals, Sweet Potato and Beans Starches
Authors: Alqah Hesham , Hussain Shahzad , Alamri Mohamed Saleh , Mohamed Abdellatif A. , Qasem Akram A. , Ibraheem Mohamed A. , Shehzad Aamir
Published: October 2023

Starches from different botanical sources are affected in the presence of enzymes. This study investigated the impact of α-amylase on several properties of pre-gelatinized starches derived from chickpea (Cicer arietinum L.), wheat (Triticum aestivum L.), corn (Zea mays L.), white beans (Phaseolus vulgaris), and sweet potatoes (Ipomoea batatas L.). Specifically, the water holding capacity, freezable water content, sugar content, and water sorption isotherm (adsorption and desorption) properties were examined. The source of α-amylase utilized in this study was a germinated sorghum (Sorghum bicolor L. Moench) extract (GSE). The starch samples were subjected to annealing at temperatures of 40, 50, and 60 °C for durations of either 30 or 60 min prior to the process of gelatinization. A significant increase in the annealing temperature and GSE resulted in a notable enhancement in both the water-holding capacity and the sugar content of the starch. The ordering of starches in terms of their freezable water content is as follows: Chickpea starch (C.P.S) > white beans starch (W.B.S) > wheat starch (W.S) > chickpea starch (C.S) > sweet potato starch (S.P.S). The Guggenheim-Anderson-de Boer (GAB) model was only employed for fitting the data, as the Brunauer–Emmett–Teller (BET) model had a low root mean square error (RMSE). The application of annealing and GSE treatment resulted in a shift of the adsorption and desorption isotherms towards greater levels of moisture content. A strong hysteresis was found in the adsorption and desorption curves, notably within the water activity range of 0.6 to 0.8. The GSE treatment and longer annealing time had an impact on the monolayer water content (mo), as well as the C and K parameters of the GAB model, irrespective of the annealing temperature. These results can be used to evaluate the applicability of starch in the pharmaceutical and food sectors.
Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases
Authors: Di Lauro Manuela , Guerriero Cristina , Cornali Kevin , Albanese Maria , Costacurta Micaela , Mercuri Nicola Biagio , Di Daniele Nicola , Noce Annalisa
Published: October 2023

In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut–brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this context, in addition to conventional pharmacological treatments for migraine, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity, and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, such as diabetes mellitus, arterial hypertension, obesity, cancer, and chronic kidney diseases, whose link is represented by gut dysbiosis.
Exploring the Nutrition Strategies Employed by Ultra-Endurance Athletes to Alleviate Exercise-Induced Gastrointestinal Symptoms—A Systematic Review
Authors: Ryan Tansy , Daly Ed , Ryan Lisa
Published: October 2023

(1) Background: Participation in ultra-endurance sports, particularly ultra-running, has increased over the previous three decades. These are accompanied by high energetic demands, which may be further exacerbated by extreme environmental conditions. Preparation is long-term, comprising of sufficient exercise management, supportive dietary habits, and nutritional intakes for optimal adaptations. Gastrointestinal symptoms are often cited as causing underperformance and incompletion of events. Though the majority do not pose serious long-term health risks, they may still arise. It has been suggested that the nutritional interventions employed by such athletes prior to, during, and after exercise have the potential to alter symptom incidence, severity, and duration. A summary of such interventions does not yet exist, making it difficult for relevant personnel to develop recommendations that simultaneously improve athletic performance by attenuating gastrointestinal symptoms. The aim of this research is to systematically review the literature investigating the effects of a nutrition intervention on ultra-endurance athletes exercise-induced gastrointestinal symptom incidence, severity, or duration. (2) Methods: A systematic review of the literature was conducted (PubMed, CINAHL, Web of Science, and Sports Discus) in January 2023 to investigate the effects of various nutrition interventions on ultra-endurance athletes’ (regardless of irritable bowel syndrome diagnosis) exercise-induced gastrointestinal symptoms. Variations of key words such as “ultra-endurance”, “gastrointestinal”, and “nutrition” were searched. The risk of bias in each paper was assessed using the ADA quality criteria checklist. (3) Results: Of the seven eligible studies, one was a single field-based case study, while the majority employed a crossover intervention design. A total of n = 105 participants (n = 50 male; n = 55 female) were included in this review. Practicing a diet low in short-chain, poorly absorbed carbohydrates, known as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs), as well as employing repetitive gut challenges of carbohydrates, remain the most promising of strategies for exercise-induced gastrointestinal symptom management. (4) Conclusion: Avoiding high-FODMAP foods and practicing repetitive gut challenges are promising methods to manage gastrointestinal symptoms. However, sample sizes are often small and lack supportive power calculations.
Room for Improvement in Sports Nutrition Knowledge amongst Parents and Caregivers of Male Academy Soccer Players in the UK: A Cross-Sectional Study
Authors: Callis Luke , Russell Mark , Hurst Howard , Hardwicke Jack , Roberts Charlie Jon
Published: October 2023

In professional soccer clubs in the UK, nutrition support is often polarised towards senior players or those in the senior academy age groups seeking first team selection/involvement. Accordingly, there is an increased reliance on parents and caregivers to provide support regarding nutritional intake. Therefore, the aim of this study was to evaluate the quality of nutrition knowledge of parents and caregivers of male youth soccer players within developmental academies in the UK. Across a single competitive season, 360 registered parents and caregivers of male soccer players from English Premier League under 9–11 (Foundation Phase) and under 12–16 (Youth Development Phase) age group academies completed an online version of the 88-item validated Nutrition for Sport Knowledge Questionnaire. Nutrition knowledge scores were classified as “poor” (43 ± 23%). Nutrition knowledge scores were significantly greater in respondents with dependents representing Category 1 (45 ± 13%) vs. Category 2 (39 ± 15%) academies and in Foundation Phase (44 ± 13%) vs. Youth Development Phase (41 ± 15%). These results demonstrate that there is room for improvement in the nutrition knowledge levels of parents and caregivers of male soccer academy players. We recommend that club academies provide appropriate resources towards nutritional education for parents and caregivers.
Chronic Cannabigerol as an Effective Therapeutic for Cisplatin-Induced Neuropathic Pain
Authors: Nachnani Rahul , Sepulveda Diana E. , Booth Jennifer L. , Zhou Shouhao , Graziane Nicholas M. , Raup-Konsavage Wesley M. , Vrana Kent E.
Published: October 2023

Cannabigerol (CBG), derived from the cannabis plant, acts as an acute analgesic in a model of cisplatin-induced peripheral neuropathy (CIPN) in mice. There are no curative, long-lasting treatments for CIPN available to humans. We investigated the ability of chronic CBG to alleviate mechanical hypersensitivity due to CIPN in mice by measuring responses to 7 and 14 days of daily CBG. We found that CBG treatment (i.p.) for 7 and 14 consecutive days significantly reduced mechanical hypersensitivity in male and female mice with CIPN and reduced pain sensitivity up to 60–70% of baseline levels (p < 0.001 for all), 24 h after the last injection. Additionally, we found that daily treatment with CBG did not evoke tolerance and did not incur significant weight change or adverse events. The efficacy of CBG was independent of the estrous cycle phase. Therefore, chronic CBG administration can provide at least 24 h of antinociceptive effect in mice. These findings support the study of CBG as a long-lasting neuropathic pain therapy, which acts without tolerance in both males and females.
Phenotypic and Genotypic Comparison of Antimicrobial-Resistant Variants of Escherichia coli and Salmonella Typhimurium Isolated from Evolution Assays with Antibiotics or Commercial Products Based on Essential Oils
Authors: Merino Natalia , Berdejo Daniel , Pagán Elisa , Girard Claire , Kerros Sylvain , Spinozzi Eleonora , Pagán Rafael , García-Gonzalo Diego
Published: October 2023

On account of the widespread development and propagation of antimicrobial-resistant (AMR) bacteria, essential oils (EOs) have emerged as potential alternatives to antibiotics. However, as already observed for antibiotics, recent studies have raised concerns regarding the potential emergence of resistant variants (RVs) to EOs. In this study, we assessed the emergence of RVs in Escherichia coli and Salmonella enterica Typhimurium after evolution assays under extended exposure to subinhibitory doses of two commercial EOs (AEN and COLIFIT) as well as to two antibiotics (amoxicillin and colistin). Phenotypic characterization of RVs from evolution assays with commercial EOs yielded no relevant increases in the minimum inhibitory concentration (MIC) of E. coli and did not even modify MIC values in S. Typhimurium. Conversely, RVs of E. coli and S. Typhimurium isolated from evolution assays with antibiotics showed increased resistance. Genotypic analysis demonstrated that resistance to commercial EOs was associated with enhanced protection against oxidative stress and redirection of cell energy toward efflux activity, while resistance to antibiotics was primarily linked to modifications in the cell binding sites of antibiotics. These findings suggest that AEN and COLIFIT could serve as safe alternatives to antibiotics in combating the emergence and dissemination of antimicrobial resistance within the agrifood system.
Adsorption and Recognition Property of Tyrosine Molecularly Imprinted Polymer Prepared via Electron Beam Irradiation
Authors: Miao Pengpai , Sang Yanan , Gao Jie , Han Xiaobing , Zhao Yuan , Chen Tao
Published: October 2023

To realize the selective separation of L-tyrosine (L-Tyr) and avoid the drawbacks of traditional thermal polymerization, electron beam irradiation polymerization was developed for the fabrication of L-Tyr molecularly imprinted polymers (MIPs). Firstly, L-Tyr MIPs were prepared with methacrylic acid and ethylene glycol dimethacrylate and without an initiator. Then, the influence of absorbed dosage and temperature on the adsorption capacity of L-Tyr, as well as the thermodynamic behavior, were investigated. The maximum adsorption capacity of 10.96 mg/g for MIPs was obtained with an irradiation dosage of 340 kGy under 15 °C, and the ΔH0 and ΔS0 of the adsorption process are −99.79 kJ/mol and −0.31 kJ/mol·K, respectively. In addition, the effect of adsorption time on adsorption performance was evaluated under different initial concentrations, and the kinetic behavior was fitted with four different models. Finally, the recognition property of the obtained MIPs was investigated with L-Tyr and two analogues. The obtained MIPs have an imprinting factor of 5.1 and relatively high selective coefficients of 3.9 and 3.5 against L-tryptophan and L-phenylalanine, respectively. This work not only provided an L-Tyr MIP with high adsorption capacity and selectivity but also provided an effective and clean method for the synthesis of MIPs.
Development of PLA/Lignin Bio-Composites Compatibilized by Ethylene Glycol Diglycidyl Ether and Poly (ethylene glycol) Diglycidyl Ether
Authors: Shakoor Shar Abdul , Wang Ningning , Chen Tianyu , Zhao Xiaoying , Weng Yunxuan
Published: October 2023

Poly (lactic acid) (PLA) is a promising green substitute for conventional petroleum-based plastics in a variety of applications. However, the wide application of PLA is still limited by its disadvantages, such as slow crystallization rate, inadequate gas barrier, thermal degradation, etc. In this study, lignin (1, 3, 5 PHR) was incorporated into PLA to improve the thermal, mechanical, and barrier properties of PLA. Two low-viscosity epoxy resins, ethylene glycol diglycidyl ether (EGDE) and poly (ethylene glycol) diglycidyl ether (PEGDE), were used as compatibilizers to enhance the performance of the composites. The addition of lignin improved the onset degradation temperature of PLA by up to 15 °C, increased PLA crystallinity, improved PLA tensile strength by approximately 15%, and improved PLA oxygen barrier by up to 58.3%. The addition of EGDE and PEGDE both decreased the glass transition, crystallization, and melting temperatures of the PLA/lignin composites, suggesting their compatabilizing and plasticizing effects, which contributed to improved oxygen barrier properties of the PLA/lignin composites. The developed PLA/lignin composites with improved thermal, mechanical, and gas barrier properties can potentially be used for green packaging applications.
Self-Pierce Riveting: Development and Assessment for Joining Polymer—Metal Hybrid Structures in Lightweight Automotive Applications
Authors: Sankaranarayanan Ramakrishnan , Hynes Navasingh Rajesh Jesudoss , Nikolova Maria P. , Królczyk Jolanta B.
Published: October 2023

In recent years, the transportation industry has faced the challenge of cutting costs, meeting increasingly stringent environmental regulations, and significantly increasing transportation volumes. One approach to meeting these challenges is to develop new, improved transportation vehicles using new materials and innovative joining techniques. Multi-material structures are becoming an alternative to body parts. Self-pierce riveting technology plays a crucial role in this process, and hybrid structures depend exclusively on it. In this article, recent advances in self-pierce riveting technology are analyzed to meet today’s challenges and future multi-material applications.