bluuebunny/crossref_metadata_2025 huggingface dataset:
HUBUNGAN ASUPAN ZAT BESI, VITAMIN C, DAN KEBIASAAN SARAPAN TERHADAP KONSENTRASI BELAJAR DI SMA TAMAN MADYA 5
Authors: Istianah Isti
Published: June 2021

Konsentrasi merupakan suatu kemampuan untuk memfokuskan pikiran. Kekurangan asupan zat besi merupakan salah satu penyebab anemia yang akan berdampak mrnurunnya konsentrasi belajar, vitamin c juga berperan untuk membantu proses penyerapan zat besi. Sarapan pagi juga merupakan hal yang penting untuk meningkatkan konsentrasi karena merupakan pasokan energi untuk otak yang paling baik untuk berkonsentrasi. Penelitian ini bertujuan untuk mengetahui bagaimana hubungan antara asupan zat besi, vitamin c dan kebiasaan sarapan terhadap konsentrasi belajar di SMA Taman Madya 5. Penelitian ini menggunakan desain cross sectional. Sampel berjumlah 36 siswi kelas 10 dan 11 yang diambil dengan teknik purposive sampling pada bulan Februari 2020. Pengumpulan data dilakukan dengan melakukan tes konsentrasi menggunakan picture completion, melakukan survei konsumsi asupan zat besi dan vitamin c dengan metode SFFQ dan wawancara kebiasaan sarapan menggunakan kuesioner. Data dianalisis dengan menggunakan uji chi-square. Hasil penelitian menunjukkan  tidak ada hubungan asupan zat besi terhadap konsentrasi belajar dengan nilai p-value 0,370, tidak ada hubungan asupan vitamin c terhadap konsentrasi belajar dengan nilai p-value 1,000 dan Ada hubungan kebiasaan sarapan terhadap konsentrasi belajar dengan nilai p-value 0,003.
INDEKS MASSA TUBUH, LINGKAR PINGGANG, DAN RASIO LINGKAR PINGGANG TINGGI BADAN SEBAGAI PREDIKSI HIPERTENSI PADA PEGAWAI
Authors: Triyanti Triyanti
Published: June 2021

Pengukuran tekanan darah yang akurat dilakukan dengan menggunakan sebuah alat yaitu mercury sphygmomanometer. Namun, terdapat keterbatasan seperti dilakukan oleh tenaga terlatih, cenderung mahal, dan berpotensi menimbulkan kontaminasi logam berat akibat kebocoran air raksa. Penelitian ini bertujuan untuk mengetahui hubungan pengukuran antropometri berupa IMT, lingkar pinggang, dan RLPT terhadap tekanan darah. Disain studi adalah cross sectional  dengan sampel 89 laki-laki dan 77 perempuan yang diambil dengan teknik systematic random sampling. Hasil penelitian menunjukkan bahwa RLPT pada laki-laki dan perempuan merupakan pengukuran alternatif terbaik untuk mendeteksi hipertensi pada usia dewasa
An Analysis of The Image of Woman Based on Yukiguni Novel by Kawabata Yasunari
Authors: Pramadityas Ainsya Rakhmidianty , Hamidah Idah , Hartati Hartati
Published: June 2021

This study is entitled with “An Analysis of the Image of Woman Based on Yukiguni Novel by Kawabata Yasunari” which purposes are to describe the characterization and the image of woman reflected on the main character, Komako. This is a qualitative descriptive study. The data are based on one of Kawabata Yasunari works, Yukiguni, 1971, which presented in narration and dialog to reflect the characterization and describe the image of woman from Komako. The data collecting method chosen is close reading technique (repeat reading). To analyse the finding, the method used in this study is narrative analysis. The findings of this study shown that the main woman character, Komako is described as a person who is easily offended, a drunkard, careless, yet neat. Her profession as Geisha displays a neat and beautiful physical image. Komako, either as a Geisha or Japanese woman, has a physic image who is easily offended, disliking liars, feeling guilty and careless. Other than that, she has a famous social image, as being well know by others, having a high sense of empathy, yet a rule breaker in which resulting her relationship between the environment she is living and herself as a person is inharmonious. To sum up, the physical images possessed by Komako is contrary with her psychic image and social.
Analisis Makna Kata Ageru, Kureru, Morau dalam Kalimat Bahasa Jepang
Authors: Meliana Igat , Savitri Dhea
Published: June 2021

Ageru (あ げ る) and Kureru (く れ る) Verbs mean "to give", while Morau (も ら う) verb means "to receive". The reaserch problem is the meaning of Ageru (あ げ る), Kureru (く れ る), Morau (も ら う) verbs that used on depending on who gives and who receives whether the closest person to the speaker (relative) or outside the scope of the speaker (other people). The method used is descriptive literature. The purpose of this study was to determine the meaning of the words Ageru, Kureru, Morau, the use of Ageru, Kureru, Morau, and the differences between Ageru, Kureru and Morau. The results of the analysis concluded that: 1. Ageru (あ げ る) which means "to give" where the first person is the speaker, to a scope far from the speaker. 2. Kureru (く れ る) which means "to give" where the second person gives to the first person (speaker), the flow of the object / gift approaches from outsiders to the speaker or relatives of the speaker. 3. Morau (も ら う) which means "to accept" is general in nature anyone can use it as an expression of acceptance of something from someone.
Kajian Psikologi Positif Konsep Ikigai pada Kaisar Akihito dalam Akihito Tennou Monogatari
Authors: Harahap Aqiilah Bilqiis Salsabiil , Lusiana Yusida , Widodo Heri
Published: June 2021

The aim of this study is to explain the relationship between the concept of Ikigai and eudaimonic happiness also with the psychological well-being of Emperor Akihito. This research is a descriptive qualitative type. The data were collected using literature study techniques which are sourced from Akihito Tennou Monogatari manga. The results found that the concept of Ikigai in Emperor Akihito, both in the form of characteristics and Ikigai pillars, all reflected Aristotle's eudaimonic happiness because it was in accordance with the virtue of an emperor, which is being a good emperor with the ability to embrace all his people and establish positive relationships with the international world. The concept of Ikigai also reflects six aspects of Ryff's psychological well-being, that is consist of 1) self-acceptance, 2) positive relationships with others, 3) autonomy, 4) environmental mastery. ), 5) purpose in life, and 6) personal growth. The conclusion is that Emperor Akihito was able to achieve eudaimonic happiness as well as psychological well-being by being a good emperor as a form of his Ikigai.
ANALISIS EFISIENSI PENGGUNAAN MODAL KERJA PADA USAHA KECIL MENENGAH DI SURABAYA
Authors: Sunarjanto Nekhasius Agus
Published: June 2021

Membangun UKM agar mampu untuk bertahan dalam kondisi persaingan yang semakin kompleks tidaklah mudah , Pelaku usaha yang telah mempersiapkan diri untuk berkompetisi akan eksis, tetapi banyak pula pengusaha yang gagal.   Berdasarkan hasil temuan penelitian sebelumnya , bahwa kegagalan bisnis UKM sangat ditentukan oleh   kemampuan pengelolaan modal kerja.  Pengelolaan modal kerja adalah mengatur  penggunaan modal kerja sesuai kebutuhan usaha.   Kebutuhan modal kerja sangat ditentukan oleh tingkat siklus konversi kas sehingga perlu memperhitungkan tingkat perputaran dari masing masing komponen di dalam modal kerja. Penelitian ini membandingkan antara penggunaan  modal kerja dengan  kebutuhan modal kerja yang harus dipenuhi oleh usaha, penggunaan modal kerja bisa  berlebihan , atau kekurangan.  Kelebihan atau kekurangan modal kerja berdampak pada ketidak efisienan perusahaan dalam menjalankan usaha, yang pada akhirnya akan mengalami kebangkrutan
Peran Kinerja Pegawai dalam Memediasi Dampak Tata Kelola Perusahaan terhadap Kinerja Keuangan
Authors: Yunanto Ary , Setyanto Refius Pradipta
Published: June 2021

Penelitian ini memiliki tujuan untuk mengetahui pengaruh penerapan prinsip-prinsip tata kelola perusahaan terhadap kinerja keuangan yang dimediasi oleh kinerja pegawai. Populasi dalam penelitian ini adalah seluruh pegawai yang bekerja pada kantor BPR BKK Purwokerto Kabupaten Banyumas. Pemilihan sampel didasarkan pada Metode pengambilan sampel bertujuan (purposive sampling). Data yang digunakan dalam penelitian ini dianalisis menggunakan partial least square dan dilakukan dengan bantuan perangkat lunak smart PLS. Hasil penelitian menunjukkan bahwa tata kelola perusahaan memiliki efek positif pada kinerja keuangan. Selain itu, hasil penelitian juga menunjukkan kinerja pegawai memediasi pada dampak tata kelola perusahaan terhadap kinerja keuangan.
Manakah yang Lebih Diminati Masyarakat?: Bukalapak, Tokopedia atau Shopee
Authors: Wijaya Dhani Wahyu , Wibawa Aji Prasetya
Published: June 2021

One of the drivers of technological advances is the Internet, which led to the occurrence of shifting trading patterns from offline to online. But the problem is that some users of e-marketplace services, such as Bukalapak, Tokopedia, and Shopee do not know what is most interested by the community. Therefore we need to do the research which one is most interested by the community. In this research conducted observations and analyses of Website features, featured Website features, promotions what is done and by using Google Trend, in a way by comparing the three e-marketplace.  The results of this study are used to find out which people are most interested in and for reference in choosing e-marketplace for the perpetrators of small and medium enterprises (SMES) or the  public.
Can Board of Directors Diversity and Monitoring Intensity Improve Bank Profitability?
Authors: Kusuma Septian Yudha , Sudarman Sudarman , Arumsari Vita
Published: June 2021

The purpose of this study to analyze the effect of board of directors diversity and monitoring intensity to profitability. Board of directors diversity measured by a composite index of gender, age, education, citizenship, and independence of the board of directors. Meanwhile, monitoring intensity measured by the composition of audit quality, number of meetings, and the number of committee. The objects are banks listed in the Indonesia Stock Exchange period of 2015-2017 with a panel data regression. Selected samples was 40 banks and 120 observation. The results showed that board of directors diversity had a significant negative on profitability, this result provoke a gap to the previous research. While monitoring intensity is positive significant to profitability. Some practical and implications will be discussed in this study.
BATERAI TES FISIK PEMAIN TENIS MEJA KELOMPOK PEMULA
Authors: Liskustyawati Hanik , Purnama Sapta Kunta , Sabarini Sri Santoso , Syaifullah Rony
Published: June 2021

Terbatasnya jumlah pemain kategori pemula sebagai pelapis pemain kategori kadet dan senior perlu segera diatasi dengan menambah kuantitas calon pemain yang potensial dan sesuai dengan keberadaannya. Pemain kategori pemula diperlukan penyiapan sedini mungkin dengan menggunakan pendekatan ilmu pengetahuan dan teknologi keolahragaan. Penyiapan pemain secara tepat masih banyak kendala yang dihadapi utamanya adalah belum tersedianya baterai tes di cabang tenis meja untuk kategori pemula.
Teknik pengumpulan data menggunakan tes dan pengukuran fisik pemain tenis meja tingkat pemula. Tes dan pengukuran meliputi: a). Tes antropometrik, yaitu: (1) tinggi badan, (2) rentang lengan, (3) panjang tungkai. b). Tes kemampuan fisik, terdiri: (1) Koordinasi mata tangan, (2) Hand reaction test, (3) Kelentukan: flexcion of thrunk, (5 ) sit and reast, (6) kecepatan lari: 20 m, (7) kelincahan: shuttle run, (8) keseimbangan: stok stand test, power otot tungkai: (9) standing broad jumps, (10) vertical power jumps, (11) power otot lengan: lempar bola medicen, (12) kekuatan: sit-up, (13) daya tahan kardiovaskuler: lari 1200 m. Subyek penelitian: peserta tenis meja kategori pemula (usia 10 – 12 tahun) yang tercatat sebagai pemain pada klub tenis meja di Kota Surakarta dan telah mengikuti latihan di masing-masing klub sekurangnya 2 tahun.
Hasil penelitian tes dan pengukuran fisik tenis meja kategori pemula dari sejumlah 15 item tes memiliki rata-rata reliabilitas tes tinggi yaitu 0,87 dan validitas tes 0,89 untuk peserta kategori putra. Sedangkan untuk peserta kategori putri diperoleh rata-rata reliabilita tes 0, 85 dan validitas tes 0,88. Baterai tes fisik pemain tenis meja kelompok pemula untuk putra maupun putri urutan tesnya meliputi: Kecepatan reaksi tangan; Tes lempar tangkap bola tenis; Shuttle run; Kecepatan lari 20 m; Lari 1200 m.
Application of Team Game Tournament Cooperative Learning Type learning model (TGT) to improve the results of learning based basic techniques in students in the XII class of Sos 4 SMAN 6 Surakarta student year 2018/2019
Authors: Saputro Muhammad Ishaq , Kristyanto Agus , Sunardi Sunardi
Published: June 2021

This study aims to improve the learning outcomes of playing football in class XII Social Sciences 4 Surakarta Senior High School 6 of 2017/2018 Academic Year. This study uses the Classroom Action Research (CAR) method. This research was conducted in two cycles, with each cycle consisting of planning, action, observation, and reflection. The research subjects were students of class XII Social Sciences 4 of SMA N 6 Surakarta in the 2017/2018 Academic Year, which numbered 25 students with details of 10 male students 15 female students. Sources of data in this study come from teachers and students. The technique of collecting data is by testing and observing during the learning activities. The data analysis technique used in this study was descriptive based on qualitative analysis with percentages. From the analysis of the data obtained the following results: In the pre-cycle, the results of learning to play football students who completed reached 44% or as many as 11 students and students who have not completed 56% or as many as 14 students. In the first cycle, the results of learning to play football students who completed reached 68% or as many as 17 students and students who have not finished 22% or as many as 8 students. In the second cycle the learning outcomes of playing football students were completed 88% or 22 students and students who had not finished 12% or as many as 3 students. The implementation of actions in cycle I and cycle II lead to an active, effective, efficient and enjoyable learning process so that it can support the occurrence of quality learning. Based on the results of the study obtained conclusions that: learning through a tactical approach, can improve learning outcomes of playing football in class XIISos 4 Surakarta N SMA 6 2018/2019 Academic Year.
ANALYSIS OF CHESS PLAYING SKILLS ON MATHEMATICS LEARNING OUTCOMES JUNIOR ATHLETES RAJA KOMBI TRENGGALEK CHESS CLUB
Authors: Setiawan Andika Yogi , Pratama Henri Gunawan
Published: June 2021

This study aims to determine the results of the analysis of chess playing skills on mathematics learning outcomes for junior athletes of the Raja Kombi Trenggalek chess club. The research method used is a qualitative descriptive method with a quantitative approach. Participants in this study were 8 junior athletes of Raja Kombi Trenggalek chess club. Data collection techniques using interviews, skills results and documentation. The data analysis in this study used the mean and percentage formula.

           After analyzing the data, the results of this study concluded that in this study, the average score of playing chess skills was 85.00, then the average score of mathematics learning outcomes was 86.25. This is of course the higher the level of achievement of skills or intellectual intelligence, the higher the level of problem solving such as in learning mathematics. This is also influenced by motor and psychological aspects as a support for intelligence skills that affect the thinking of athletes. Then from the data analysis it can be said that the higher the level of achievement of chess playing skills, the higher the level of problem solving as in learning mathematics
Prokrastinasi Sholat: Analisis Teori Perilaku Terencana
Authors: Purwandari Eny , Irawan Asep
Published: June 2021

Sholat is an obligation for Muslims. Sholat obligations are determined in a day are marked by a call, the name adzan. In Indonesia, with a majority Muslim population, the signs of sholat times are very easy to recognize. But not a few ignore it. The purpose of this study is to understand sholat as a behavior from the perspective of planned behavior. This research is a qualitative descriptive study, with data collection using an open-ended questionnaire and a pocket book as a daily sholat record that informants must fill in for 2 weeks. The informants were 72 under-graduate students, both male and female. The results of this study indicate that the attitude of continuing to sholat in the given timeframe, but not necessarily at the beginning of the sholat time because there are other tasks. The presence of a family is very important as an influential person who reminds him to immediately perform sholat (as a subjective norm). Other things that are 2 considered more important and must be done besides sholat strengthen the intention to postpone praying. The behavior of postponing sholat is very strong based on these findings, because it forms attitudes, family influences and activities, which are more importantly less controllable. Therefore, a positive attitude so that prayers on time need to be built, the presence of the family is very dominant and put other things for a while to be continued after the prayer needs to be removed so that the procrastination of sholat does not occur
Investigation on Alamparai Fort by Utilization of Organic Materials for Improvement of Stability of Heritage Structure
Authors: Santhanam Kotteeswaran , Ramadoss Ravi
Published: June 2021

Heritage structures are valuable monuments to describe the culture and traditions of the country. These heritage structures get deformed in today's scenario by natural or artificial disasters. Hence, to preserve these heritage structures, restoration was introduced to restore the ancient building with new binding agents. Rehabilitation can take place only by analysing the properties of existing structures. Based on the existing structure properties, the alternative binding agent selected; can regain the same strength and shape of the heritage structures. Based on these, the restoration of Alamparai fort was performed by analysing the fort materials using mortar strength analysis by core-drilling, double punch test, and small-scale masonry test. The arch properties are also analysed by performing seismic analysis based on the mortar strength properties. The stability analysis of the organic and existing materials shows that Gur and haritaki is the best agent for restoring the fort. Hence, the mortar strength and seismic analysis of these materials performed using diagonal shear test and seismic modelling of the fort. The proposed material strength tests results indicate that the Gur and Haritaki is the best agent to restore the fort. The fort was restored with these materials; it survived in Nivar cyclone crossed on 26th November 2020.
A Detailed Analysis Of Clinical Measurement Error In Ultrafiltration In Peritoneal Dialysis
Authors: Yu Zanzhe , Wang Zhuqing , Wang Qin , Zhang Minfang , Jin Haijiao , Ding Li , Yan Hao , Huang Jiaying , Jin Yan , Davies Simon , Fang Wei , Ni Zhaohui
Published: June 2021

BackgroundIt has been noticed for years that ultrafiltration is important for survival in peritoneal dialysis. On the other hand, ultrafiltration measurement is much more complicated than it thought to be. Both overfill and flush before fill used to be source of measurement error. However, controversy finding around ultrafiltration in peritoneal dialysis still exists.MethodsFour different brands of dialysate were purchased from the market. The freshest dialysate available in the market were intentionally picked. The dialysate were all 2L, 2.5% dextrose and traditional lactate buffered PD solution. They were stored in four different conditions with controlled temperature and humidity. The bags were weight at baseline, 6 months and 12 months of storage. Specific gravity was measured in mixed 24 hour drainage dialysate from 261 CAPD patients in a cross sectional manner. ResultsThere was significant difference in dialysate bag weight at baseline between brands. The weight declined significantly after 12 months storage. The weight loss was more significant in higher temperature and lower humidity. The dialysate in non-PVC package lose less weight than PVC package. The specific gravity of dialysate drainage was significantly higher than pure water and related to dialysate protein concentration.ConclusionStorage condition and duration, as well as the type of the dialysate package gave extra variance in overfill volume. The fact that specific gravity of dialysate drainage is higher than 1g/ml also contributes to systemic measurement error of ultrafiltration in manual exchanges.Trial Registration: ClinicalTrials.gov ID: NCT03864120 (March 8, 2019) (Understand the Difference Between Clinical Measured Ultrafiltration and Real Ultrafiltration)
Studying on the Addition Reaction Mechanism of Ethylene and Butadiene Based on Density Functional Theory
Authors: Li Kangning , Ma Wei-lin , Xie Wen-li
Published: June 2021

According to the first principle calculation, the addition reaction mechanism of ethylene and butadiene is determined. The reactant, transition state (TS) and product of this addition reaction are confirmed by optimization calculation and frequency analysis. To verify the correctness of the reaction process, we also calculated the reaction path. Result demonstrates that the addition reaction of ethylene and butadiene is an exothermic reaction. Charge transfer is used to explain this novel reaction. The activation energy of the addition reaction of ethylene and butadiene is 0.83 eV, and the heat release of the whole reaction is 2.01 eV. The molecular structure, charge distribution and energy of butadiene and ethylene are investigated at the molecular level. The calculated activation energy is helpful for understanding the cyclic addition reaction of butadiene and ethylene, providing theoretical guidance for experiments and deepening people's understanding of this reaction.
Comprehensive assessment of groundwater quality using heavy metal pollution indices and geospatial technique: A case study from Wanaparthy watershed of upper Krishna River basin, Telangana, India.
Authors: Vaiphei Suantak Paolalsiam , Kurakalva Rama Mohan
Published: June 2021

The present study is to characterize groundwater quality using heavy metal pollution indices and geospatial variations. A total of 58 samples from hand pump/submersible bore wells were collected from the Wanaparthy watershed of the upper Krishna River basin according to the grid size (5*6 km 2 ). The heavy metals concentration in groundwater samples are found in the order of Zn(38.67%)> B(32.67%)> Ba(13.59%)> As(8.49%)> Hg(3.71%)> Cr(1.28%)> Ni(0.52%)> Cd(0.47%). Among these heavy metals, arsenic (22.4%) and mercury (5.1%) were found above the permissible limits of WHO drinking water guideline values. A positive correlation between pH versus B/Ba/Hg, TH versus EC/TDS, and B versus Ba indicates the presence of metals due to chemical reaction (rock-water interaction). Arsenic correlation with EC/TDS/TH indicates artificial intervention. Drainage network analysis enumerates high concentration of parameters at near or joining to upper order of drainage system, which might be due to input of runoff water (interaction of variable rocks composition) and later stage infiltration to subsurface and reached to an aquifer. Heavy metal pollution index (HPI) showed 86.2% of samples are in the category of low class, whereas 12.1% of samples fall within medium class. According to metal index (MI) classification, 12.1% samples are in very pure, 24.14% samples are pure, while the remaining 63.8% samples are in the slightly to strongly affect category. This study suggested the main source of heavy metals in groundwater might be from the dominant granitoid rocks because the area is mostly devoid of industrialization.
Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum
Authors: Dong Jingwei , Gao Kun , Qian Pingkang , Li Bin , Xue Chunye , Gao Zheng , Liu Qiaoqiao , Deng Xiangyuan
Published: June 2021

In this work, Phaeodactylum tricornutum was used to investigate the toxicity of 4,4'-dibromodiphenyl ether (BDE-15). Results showed that BDE-15 inhibited the photosynthetic activity and growth of P. tricornutum significantly with 24, 48, 72, and 96 h EC50 values of 1.03, 0.44, 0.41, and 0.42 mg L-1, respectively, indicating that it was a highly toxic substance. Moreover, BDE-15 could cause cell deformation, and a series of physiological, biochemical, and molecular changes in the cells. Under the exposure of BDE-15, contents of chlorophyll a and soluble protein decreased significantly, but reactive oxygen species (ROS) were accumulated in the algal cells, which may cause or intensify the peroxidation of membrane lipids. For alleviating the toxicity of excessive ROS, activities of antioxidant enzymes increased dramatically when this diatom was exposed to BDE-15. Thus, it is concluded that the overproduction of ROS may be regarded as one of the major factors in BDE-15 toxicity.
Identification of Ten-LncRNA Signatures Predict Disease-Free and Overall Survival for Hepatocellular Carcinoma
Authors: Lu Jiong , Yang Sishu , xiong xianze
Published: June 2021

Background: The prognosis of hepatocellular carcinoma (HCC) is bleak though it has been improved over recent years. Early diagnosis could improve the survival. Plenty of researches indicate that long non-coding RNAs (lncRNAs) could play an important role in prognostic prediction of cancer as a kind of biomarker. Methods: We downloaded clinicopathological characteristics and lncRNA expression data of HCC patients from The Cancer Genome Atlas (TCGA) database. The ratio of training sets to validation sets was 2:1. Significant differentially expressed lncRNAs were identified by log-rank test and cox regression. All the significant lncRNAs were selected into the least absolute shrinkage and selection operator regression (LASSO) analysis and constructed risk-score formula by linear combination. Performance of the signatures were validated by receiver operating characteristics (ROC) curves and Kaplan-Meier survival curves. The correlated messenger RNAs (mRNA) were evaluated by functional enrichment analysis. Results: We identified and validated ten-lncRNAs based signatures to predict disease-free survival (DFS) and overall survival (OS) of HCC respectively. Stratified survival analysis showed that the performance of lncRNAs related signatures was better than tumor, node, metastasis(TNM) staging system. Functional enrichment analysis showed that organelle fission and regulation of mRNA metabolic process were significantly enriched in differentially expressed lncRNAs (DElncRNAs). Transcriptional misregulation in cancer and mitogen-activated protein kinase (MAPK) signaling pathway were significantly enriched pathways in the pathway enrichment analysis. Conclusion: we constructed two lncRNAs based signatures which could predict prognosis of HCC more accurate than the traditional ways.
Phreatic Surface Estimation In MSE Wall With Geocomposite Back Drainage
Authors: Chinkulkijniwat Avirut , Horpibulsuk Suksun , Duong Hai La , Quang Thien Do
Published: June 2021

This study proposes a simple mathematic model for approximating the level of phreatic surface inside the protected zone in mechanical stabilized earth wall with back drain installation though the position of phreatic surface at the drainage interface (ho) which reflects the maximum level of phreatic surface in the protected zone. The proposed model was established based on dataset taken from 180 simulation cases caried out in Plaxis environment. Regression results present a combination of significant effects and major role to maximum water level in the protected zone (ho) of a ratio of length from upstream water to the drainage face to the wall height (L/H), a soil permeabilities coefficient (k) and a transmissivity of the drainage material (Tnet). The proposed model can facilitate design of drainage material to achieve desired level of phreatic surface in the protected zone.
WITHDRAWN: Decellularized Lung Extracellular Matrix Scaffold Promotes Human Embryonic Stem Cell Differentiation Towards Alveolar Progenitors
Authors: Noori Afshin , Dezfouli Mohammad Reza Mokhber , Rajabi Sarah , Ganji Fatemeh , Ghezelayagh Zahra , Agha Elie El , Baharvand Hossein , Chaleshtori Sirous Sadeghian , Tahamtani Yaser
Published: June 2021

Efficient production of alveolar epithelial cells and achieving optimal functionality and maturity has presented a serious challenge in recent years. The extracellular matrix (ECM) provides a dynamic environment and mediates cellular responses during both development and tissue repair. Decellularized ECM (dECM) which retains its native-like structure and biochemical composition provides the signals needed to induce differentiation into tissue-specific lineages in vitro. Here, we repopulated lung ECM-derived scaffold (scaffold) with human embryonic stem cells (hESCs) derived lung progenitor cells and compared with the cells grown on either lung ECM-derived hydrogel (hydrogel) or fibronectin-coated plates in 2D cultures. We found that scaffold preserved its composition and native structures. All groups displayed progenitor cell differentiation as revealed by the expression of NKX2.1, P63, and CK5. Although no significant differences in cell viability between groups, cells differentiated on scaffold and hydrogel showed significant upregulation of SOX9 (a marker of the distal airway epithelium), cells differentiated on scaffold showed enhanced expression of SFTPC (AT2 marker), FOXJ1 (ciliated cell marker) and MUC5A (secretory cell marker). Overall, our results suggest that scaffold improves differentiation of progenitors into alveolar type 2 cells in comparison with hydrogel and fibronectin as well as efficient retention and homing to the alveolar region.
Lactobacillus Plantarum LRCC5314 Includes a Gene for a Substance that Stimulates the Secretion of Serotonin
Authors: Jeong Jiseon , Yoon Seokmin , Kim Jong-Hwa , Kim Wonyong
Published: June 2021

Background: As the functions of probiotics within the same species may not be shared, it is important to analyze the genetic characteristics of strains to determine their safety and usefulness before industrial applications. Results: The complete genome of Lactobacillus plantarum LRCC5314 isolated from kimchi was acquired through PacBio sequencing to confirm probiotic functions and genetic characteristics. Phylogenetic and comparative genomic analyses were performed between L. plantarum LRCC5314 and L. plantarum ATCC 14917T, and the results showed that two strains were highly similar. However, there were some genetic differences. The characteristics of carbon source metabolism were also determined based on the KEGG database and physiological properties. L. plantarum LRCC5314 could metabolize hexoses through homofermentation, which produces only lactic acid. According to gene annotation, L. plantarum LRCC5314 could encode almost complete biosynthetic pathway to produce tryptophan, which can be used as a precursor of serotonin. The serotonin ELISA test using Caco-2 and HT-22 cells treated with a supernatant of the bacterial culture showed that more serotonin was produced by treated cells than by untreated cells.Conclusion: L. plantarum LRCC5314 could provide a source for serotonin production, and L. plantarum LRCC5314 could be used as a functional probiotic for stress regulation.
Manga Translation and Censorship Issues in Malaysia
Authors: Chow Yean Fun , Che Omar Hasuria , Abdul Rahman Wan Rose Eliza
Published: June 2021

In manga translation, when original image and written representations are regarded as inappropriate content to the target readers’ socio-cultural context, censorship is imposed. Nevertheless, research on censorship in manga translation in Malaysia has not been given due attention. Previous studies show that self-censorship influences translation, but it is not examined within the scope of manga translation. As such, the objective of this study is to examine the censorship practices in manga translation in Malaysia. This study adopts a qualitative content analysis approach to analyse six Malay translations and their respective source texts based on the publishing guideline of the Printing Presses and Publications Act 1984 [Act 301] and translation procedures proposed by Klaus Kaindl. The analysis shows that the censorship practice in manga translation is a combination of institutional and self-censorship. In institutional censorship, the translation procedures of detraction, addition, substitution, deletion and couplets are used, while in self-censorship, the process is involves substitution, deletion and addition. The current study recommends the adoption of institutional censorship procedures as guidelines in handling sensitive representations and a review of the self-censorship procedures to ensure faithful translations.
Prevalence rate of cornea diseases according materials of outpatient facilities in Baku city
Authors: Maharramov P. M.
Published: June 2021

Purpose: to assess the prevalence of corneal diseases using the data on the incidence of visits to outpatient facilities in the city of Baku. Material and methods. The data, presented by outpatient facilities for the year 2017, were statistically analyzed. Results. It was revealed that, for every 100 000 people, there were 266.1±3.4 cases of corneal diseases of which 97.9 ± 2.1 were infectious and 166.9 ± 2.7 were noninfectious diseases. Corneal neoplasms were detected in 1.3 ± 0.2 cases. The ratio of non-infectious and infectious diseases ofthe cornea was ca. 1.7. The lowest prevalence rate of both infectious and non-infectious diseases of the cornea was detected in children aged 0 to 9 years. In older age groups, the change of prevalence of corneal diseases was found to be chaotic. The trends of age-related prevalenceof infectious vs. non-infectious diseases of the cornea were basically similar; the highest rate was detected among patients aged 60–69. Conclusion.According to the appealability data, the prevalence rate of corneal diseases is rather high and age-dependent with a prevailing share of non-infectious corneal pathologies. In male population, this rate is notably lower than in female population.
An ANCOVA analysis of the results of planned and actually obtained hypocorrection after excimer laser surgery in middle-aged patients with myopia
Authors: Khodzhabekyan N. V. , Tarutta E. P. , Khandzhyan A. T. , Sengaeva M. D. , Ivanova A. V. , Letnikova K. B. , Sklyarova A. S.
Published: June 2021

Purpose: a covariance analysis of the planned and actually obtained refraction after excimer laser myopia correction surgery in middle-aged patients. Material and methods. 85 patients (170 eyes) aged 35 to 50 underwent excimer laser myopia correction surgery by FemtoLASIK. The patients were divided into 3 groups according to the degree of myopia: group 1 included 13 patients (26 eyes) with myopia from -1.25 to -3.0 D, group 2 had 42 patients (84 myopic eyes) from -3.25 to -6.0 D and group 3 had 30 patients (60 eyes) with myopia of -6.25 D or higher. Results. The patients with low myopia, independently of the age, revealed a postoperative refraction effect closer to that planned than the patients with moderate and high myopia. The difference (delta) between the planned and the obtained results was -0.35 ± 0.08 D (41%) in group 1, -0.58 ± 0.04 D (51.3%) in group 2 and -0.64 ± 0.05 D (46%) in group 3. The divergence between the respective indicators for figures for low and high myopic groups is statistically significant. Conclusion.Patients with low myopia over 35 years old can be recommended a symmetric hypocorrection in binocular format irrespective of the objective data regarding the initial corneal hydration, which affects the ablation volume. To achieve a better agreement between the planned and the actual hypoeffect (and, accordingly, a more precise dosage of the surgery) in patients with moderate and high myopia, it is important to introduce into clinical practice the technology of contactless measurement of corneal hydration.
Phacoemulsification and calculation of intraocular lenses in patients given keratorefractive surgery. Part 1
Authors: Ioshin I. E.
Published: June 2021

Rationale.Qualitative rehabilitation of patients with cataracts who had keratorefractive surgeries depends on phacoemulsification technology and correctly calculated optical power of the IOL. Purpose: present the author’s own approaches to the development of surgical tactics for treating patients with cataracts who underwent keratorefractive surgeries. Material and methods. The complicated character of cataract surgery performed after LASIK — deterioration of visualization due to the presence of an optical ablation zone and a transition zone (6–7 mm) — is successfully compensated by instillations of a dispersed viscoelastic (methylcellulose) onto the surface of the cornea. Another factor is the deepening of the anterior chamber in high myopia, which is uncomfortable for manipulation and may require a lowerlevel of irrigation (up to 60 mm Hg). The technology of surgery performed after radial keratotomy (RK) requires utmost attention to the prevention of surgical astigmatism that could emerge due to biomechanical instability of the cornea. To ensure such prevention, paracentesis is performed outside the zone of keratotomy scars, the main 2.2 mm incision is made after capsulorhexis in the sclerolimbal zone, and at theend of the operation, a subconjunctival injection is performed in the conjunctival zone of the knife keratom entrance for the tamponade ofthe outer part of the incision without suturing. These techniques made it possible to successfully perform more than 200 operations and achieve a favorable course of the postoperative period from the first day. Fast adaptation of the incision (1–2 days), uncomplicated course of the postoperative period and the absence of induced astigmatism are important advantages of this technology. Conclusion. The choice of surgical technology, taking into account the initial state of the eye after LASIK and RK surgeries, is an important task. Yet the main problem with which the doctor is faced after keratorefractive surgery is the difficulty of calculating the optical power of the IOL which must take into account the special needs of the patient with a particular refractive history, which will be reported in part 2 of the article.
Mixed (combined) phenotype of the late stage of age-related macular degeneration
Authors: Neroeva N. V. , Neroev V. V. , Ryabina M. V. , Karmokova A. G. , Losanova O. A.
Published: June 2021

With multimodal visualization of the chorioretinal complex structures using modern research methods, it was possible to isolatea mixed, or combined, phenotype of the late stage of age-related macular degeneration (AMD). Early detection of this AMD form is of vital importance not only for accurate diagnosis, but for choosing optimal management tactics for patients. The paper presents two clinical cases with different variants of the development of the mixed phenotype of the late AMD stage. In one case, the long-lasting “geographic atrophy” (GA) was complicated by the development of choroidal neovascularization, while in the other case GA appeared during the treatment of wetAMD.
Optical coherence tomography in patients with somatotropin-producing pituitary adenoma
Authors: Gavrilova N. A. , Gadzhieva N. S. , Kuz’mina A. V.
Published: June 2021

Optical coherence tomography (OCT) is widely used in ophthalmological practice. The review presents the results of OCT in patients with somatotropin-producing pituitary adenoma, or somatotropinoma, which is a hormone-active tumor of the adenohypophysis, characterized by excessive production of somatotropic hormone (STH). It stimulates the secretion of type I insulin-like growth factor (IGF-I). The mechanisms of STH action (pro-angiogenic action, stimulation endothelial cell proliferation and migration, development of endothelial dysfunction and retinal edema) requires much attention to the results of examination of patients with somatotropinomas using modern diagnostic methods, such as OCT.
Discovery of a “Cocktail” of Potential SARS-COV-2 Main Protease Inhibitors through Virtual Screening of Known Chemical Components of Vitex negundo L. (“Lagundi”)
Authors: Cayona Ruel , Creencia Evelyn
Published: June 2021

Aim:

The prevailing crisis caused by the COVID-19 pandemic demands the development of effective therapeutic agents that can be implemented with minimal to zero adverse effects.

Background:

Vitex negundo L. (VNL) is a medicinal plant with reported efficacy against respiratory diseases and some of the COVID-19 symptoms. Funded by the Department of Science and Technology (DOST), the University of the Philippines – Philippine General Hospital (UP-PGH) is currently conducting clinical trials of VNL and other medicinal plants as adjuvant therapeutic agents against mild cases of COVID-19. The basis for the clinical trials is primarily the pharmacological efficacy of the medicinal plants against respiratory disorders and associated COVID-19 symptoms.

Objective:

This study assessed the in silico potential of VNL components against SARS-CoV-2 main protease (Mpro), an enzyme that plays an important role in COVID-19, the disease caused by the SARS-CoV-2.

Objective:

This study assessed the in silico potential of VNL components against SARS-CoV-2 main protease (Mpro), an enzyme that plays an important role in COVID-19, the disease caused by the SARS-CoV-2.

Method:

Phytochemical mining of VNL components from the literature was conducted. A database consisting of 250 known compounds from different parts of VNL was created and screened against SARS-CoV-2 Mpro using the PyRx virtual screening tool. The most promising components were further subjected to in silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) analyses using the SwissADME web server and Toxtree software.

Results:

Virtual screening revealed that 102 VNL components in the database had comparable to or better binding affinities toward SARS-COV-2 Mpro than known chemical inhibitors (e.g. N3 and carmofur). It was determined that the active site of SARS-CoV-2 Mpro receptor consists of multiple H-donor and acceptor sites; hence, the most stable receptor-ligand complexes are generally formed by VNL ligands that establish effective H-bonding with the SARS-CoV-2 Mpro. The promising components, representing a “cocktail” of potential inhibitors also revealed interesting ADMET properties.

Conclusion:

This in silico study identified VNL as a potential single source of a cocktail of SARS-CoV-2 Mpro inhibitors and a promising adjuvant therapeutic agent against COVID-19 or its symptoms. Furthermore, the study offers a rationale on phytochemical mining from medicinal plants as a means that can be implemented in the early stage of a drug discovery and development program.
Optimization and In vitro Evaluation of Famotidine Loaded Effervescent Orally Disintegrating Tablets Using Central Composite Design
Authors: Kumar Ramesh , Verma Ravinder , Kaushik Ritu , Kaushik Prerna , Pandey Parijat , Purohit Deepika , Mittal Vineet , Kaushik Deepak
Published: June 2021

Background:

Over the years, effervescent orally disintegrating tablets (ODTs) have proved
their worth over conventional tablets in overcoming the swallowing problems associated with the geriatric
and pediatric population. The addition of effervescent agents in ODT provides a rapid disintegration
along with masking of the slight bitter taste of drugs and is worth exploring.

Objective:

The present research investigation deals with the preparation of effervescent ODTs by direct
compression with rapid disintegration and adequate hardness using the central composite design
response surface methodology.

Methods:

Central composite design was used to study the effect of concentration of crospovidone (X1)
and concentration of citric acid and sodium bicarbonate (X2) as independent factors on the two responses:
disintegration time (Y1) and drug release (Y2). The tablets were prepared by direct compression
approach using directly compressible mannitol.

Results:

The optimization results obtained after application of ANOVA revealed that increase in the
concentration of X1 and X2 resulted in the increase in disintegration time and % CDR. Following the
statistical analysis of the results, the formulation batch (F-7) with a desirability index of 0.95 was chosen
as optimized batch and exhibited 99±0.8 % release of the drug after 5 min, and rapid disintegrating
time of 31±3 sec. All other tablet attributes were well within the official limits.

Conclusion:

The results obtained in the present investigation clearly revealed a successful development
of famotidine effervescent ODTs with a better release profile in comparison to marketed formulation.
Wpływ infrastruktury na zachowania kierowców na przejściach dla pieszych na przykładzie Warszawy i Radomia
Authors: Sulmicki Maciej
Published: June 2021

W 2019 r. przeprowadzone zostały badania wpływu rozwiązań infrastrukturalnych na przejściach dla pieszych i przejazdach dla rowerzystów na zachowania kierowców. Celem ramowym przeprowadzonych badań była weryfikacja trafności zapisów zawartych w dokumentach strategicznych i planistycznych województwa mazowieckiego odnoszących się do bezpieczeństwa ruchu drogowego. Lokalizacje w Warszawie i Radomiu zostały dobrane w taki sposób, aby uwzględnione zostały wszystkie wymienione w Planie zagospodarowania przestrzennego województwa mazowieckiego rodzaje uspokojenia ruchu mające służyć poprawie bezpieczeństwa i dotyczące bezpośrednio przejść dla pieszych. Jednocześnie pod uwagę brane były takie czynniki jak przekrój jezdni, układ skrzyżowania i sygnalizacja świetlna. Podczas badań obserwowano zachowania kierowców względem niezmotoryzowanych oraz te, które determinowały możliwość szybkiego zareagowania na pojawienie się niezmotoryzowanego uczestnika ruchu. Badania były prowadzone z punktów obserwacyjnych oddalonych od skrzyżowania, by nie wpływać na zachowanie uczestników ruchu. Na podstawie co najmniej trzydziestominutowych obserwacji w terenie oraz późniejszej analizy nagrań notowano, czy: kierowca zatrzymuje się przed przejściem, wjeżdża przed lub za niezmotoryzowanego, zatrzymuje się na przejściu, wjeżdża szybko na przejście. W wybranych lokalizacjach analizowano również, czy kierowca rozgląda się przed wjazdem na przejście, jednak w większości miejsc nie było to możliwe ze względu na duże natężenie ruchu i/lub nieodpowiednią widoczność. Obserwacje w Radomiu zostały przeprowadzone przez Sebastiana Pawłowskiego i Łukasza Zaborowskiego z Mazowieckiego Biura Planowania Regionalnego, Oddziału Terenowego w Radomiu. Wyniki badań wskazują, że na niebezpieczne zachowania kierowców mają wpływ: przekrój jezdni na przejściu dla pieszych, obecność przejazdów dla rowerzystów i zasady pierwszeństwa, fizyczne środki uspokojenia ruchu oraz sygnalizacja świetlna. Wykazano, że nieskutecznym rozwiązaniem jest powierzchnia wyłączona z ruchu jedynie za pomocą oznakowania poziomego oraz czerwone światło z dopuszczonym warunkowym prawoskrętem (zieloną strzałką), które traktowane jest jako zielone światło. Badania terenowe potwierdziły słuszność zapisów zawartych w dokumentach strategicznych i planistycznych województwa mazowieckiego, jak też konieczność ich szerszego stosowania. Analiza wyników pozwoliła wykazać konkretne zależności pomiędzy różnymi parametrami rozwiązań a ich wpływem na zachowania kierowców, co stanowi uzupełnienie prowadzonych wcześniej badań lokalnych oraz na poziomie krajowym, przeprowadzonych w 2018 r.