bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of requirements for confidentiality and exchange of digital health data
Authors: Alzubaidi AK
Published: December 2023

The article provides answers to immediate questions associated with the state regulation of confidentiality of information and exchange of data in the era of digital healthcare. The institute of medical confidentiality which originated in the ancient world is still evolving throughout the development of medical law. In the current era of global digitalization, however, the issues related to data confidentiality have become more relevant than ever. With all the modern technologies and digital health care platforms on the rise, new challenges associated with protection of these patients are emerging. To ensure the reliable protection of patient’s personal and medical information, doctors and medical institutions have to meet data security standards. It becomes vital to develop effective strategies and mechanisms to prevent unauthorized access and data leakage due to a larger volume of electronic medical records and digital data exchange. Strict rules and standards regulating collection, storage and transfer of medical data belong to a key aspect in this area. The Russian Federation is making great efforts to create the legislation which could protect the rights of patients and made medical establishments to follow the high standards of confidentiality, and to develop technical aids that provide data encryption and protection against hacker attacks.
Analysis of Water Resources in the Arid Region of Saratov Oblast Based on Satellite Information
Authors: Kuzyanov Dmitrij , Erdniev Leonid , Gusev Yurij , Mikerov Anatolij
Published: December 2023

The problem of water supply in arid regions is still topical and needs to be studied. The aim of the study was to develop a program for the analysis of the dynamics of water resources from the satellite images of the Saratov region. The analysis of the images made it possible to create a program for calculation of the water surface area of the water bodies used for estimation of the water reserves dynamics depending on climatic and anthropogenic factors from 2007 to 2022. The water bodies located in the most arid area of the arid region of Saratov region and used by the population for household and drinking water supply were investigated in the work. The results showed a direct marked relationship between the volumes of spring water supply and precipitation. Also revealed a direct high correlation between the reduction of water reserves in summer and the volume of precipitation from May to August. The program and revealed regularities can be used for estimation of water reserves in artificial lakes and rivers of arid regions.
The mixed-method approach to identify perceived reasons for increased procrastination among students during the first pandemic lockdown in Poland
Authors: Kawczyński Marcel , Wiwatowska Ewa , Michałowski Jarosław
Published: December 2023

The beginning of the COVID-19 pandemic brought about a sudden and significant change in the conditions of various academic activities. In the present study, we wanted to investigate the influence of the first pandemic lockdown on procrastination tendencies among Polish students. To achieve this goal we employed a mixed-method, embedded longitudinal study. In the quantitative part of the research, the same group of university students completed the procrastination questionnaire twice: a year before, and two months after the introduction of the first pandemic lockdown. The qualitative part included the open-ended questions about the perceived reasons for an observed change in a tendency to postpone tasks after the pandemic outbreak. Our analyses showed a significant increase in academic procrastination after the lockdown introduction. In particular, students reported a decrease in the study interest and lower working discipline. As the causes of higher procrastination during the lockdown period, students most frequently pointed out the reduced monitoring of work progress by supervisors and lower negative consequences of delaying tasks. The second most frequent theme in provided answers included difficulty in restraining from alternative activities and problems with focusing on tasks or ignoring distractions. Embedding qualitative and quantitative data gave a consistent picture of students' situation in the first lockdown and provided potential explanation for the exacerbation of procrastinatory behaviors after the pandemic outbreak.
Research on the Tensile Behavior of the Stucco Sheets
Authors: Stoian Elena Valentina , Enescu Maria Cristiana , Negrea Daniel Alexis , Mihai Simona , Petre Ivona Camelia , Rusănescu Carmen Otilia
Published: December 2023

The paper presents the influence of impurities and alloying elements on the properties and characteristics of aluminum sheets. The researches were carried out on the Stucco aluminum sheet with dimensions of 120 × 50 × 85 mm, used to make billboards, roofs, containers, films, kitchenware, chemical equipment, vaporizers for refrigerators, etc. The sheet is made of non-alloyed aluminum, according to the EN-AW 1050 standard and belongs to the 1xxx class. The sheets have a high percentage of aluminum in their chemical composition, approximately 99.5%. The aim of the work was to subject the samples from this type of material to mechanical tensile stress and to measure their modulus of elasticity.
Aspects Regarding the Effects of Some Influence Factors on the Uncertainty Budget of Optical Emission Spectrochemical Tests with Excitation by Spark or Electric Arc
Authors: Anghelina Florina Violeta , Popa Ion Florin , Popa Carmen , Popescu Ileana Nicoleta
Published: December 2023

In this work, a number of significant factors are highlighted that affect the optical emission spectrochemical tests with spark or electric arc excitation on stainless steels with multiple synergistic purposes such as: acquiring new knowledge, increasing the amount of information obtained about the material, increasing the efficiency and quality of the tests, the characterization of special purpose alloys and the assessment of their compliance with the specified requirements. In this direction, it requires both knowledge of testing methods (theoretical basis, test method, procedure related to the method, quality assurance testing) and the characteristics of the investigated materials. These aspects are necessary for the analysis of the test system and the most correct preliminary interpretation of the experimental results.
Digital Inheritance of Traditional Mongolian Robes of the Nayman Tribe
Authors: Shi Hui , Duan Ting , Yu Xiao , Dong Qi
Published: December 2023

The Mongolian robe is the crystallisation of the wisdom of Mongolian people after a long period of social practice and one of the intangible cultural heritages of humanity. With the gradual disappearance of the nomadic lifestyle in the steppe, it is not easy to protect and pass on traditional Mongolian dress culture and traditional handicraft technology. This study used the digital twin concept to construct a digital twin to try on clothes for a model in a virtual environment, to realise a mirror image presentation of the target physical entity, and to use effective modern technology to protect and pass on the traditional clothing. The experiment used an AlphaM4 3D body scanner to obtain a 3D human body model, as well as reverse engineering technology to process the initial data, such as noise reduction, streamlining, hole patching and smoothing to build a personalised human body model. The traditional black cotton robe of the Nayman tribe researched in the field was mapped by the planar structure design method, and its structure and 2D samples were recovered. A 3D model of the traditional cotton robe of the Nayman tribe was established based on 3D simulation technology to achieve a 3D virtual display effect, enable better dissemination and inheritance, and give a new vitality to non-heritage clothing in the digital era. The research results can provide fresh ideas and technical support for the digital estate and development of other traditional costumes, as well as contribute to the construction of digital resources for intangible cultural heritage.
Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis
Authors: Gatseva Preslava R. , Blazhev Alexander B. , Yordanov Zarko Y. , Atanasova Victoria G.
Published: December 2023

The aim of this study was to determine the potential of early inflammatory markers to diagnose late-onset neonatal sepsis – interleukin 6 (IL-6), interleukin 8 (IL-8) and endocan (ESM-1), and to compare them with routinely used markers like C-reactive protein (CRP) and procalcitonin (PCT). A prospective (January, 2022 – January, 2023) clinical-epidemiological study was conducted in a third level NICU in Pleven, Bulgaria. Patients with suspected nosocomial infection and healthy controls were tested. A sandwich ELISA method was used to measure the serum concentrations. Sixty newborns with an average gestational age of 29.75±3.61 gestational weeks were included, of which 35% were symptomatic and infected, 33.3% were symptomatic but uninfected, and 31.7% were asymptomatic controls. The mean values of PCT and IL-6 differ significantly in the three groups. For ESM-1, IL-8 and CRP, the difference was statistically insignificant. The best sensitivity (78%) and negative predictive value (84%) was found for IL-6. The introduction into routine practice of indicators such as PCT and IL-6 may provide an opportunity to promptly optimize the diagnostic and therapeutic approach to LOS.
Predictors for Gangrene and Perforation of Gallbladder Wall in Patients with Acute Cholecystitis
Authors: Marinova Polina G.
Published: December 2023

Perforation of the gallbladder wall leads to a local perivesical abscess or progression to biliary peritonitis. The study aimed to analyse clinical, laboratory, and imaging indicators that have the strongest relationship with the presence of gangrenous cholecystitis and perforation of the wall and to design a predictive scoring system that highlights the risk of developing gangrenous cholecystitis with perforation. We performed a retrospective analysis of a total of 331 patients operated for five years (2016-2020) at the Department of Surgical Diseases” of Medical University - Pleven, with histologically verified chronic cholecystitis (120 patients; 36.4%), acute cholecystitis (100 patients; 30.1%), and destructive cholecystitis (111 patients; 33.5%). The statistical analysis identified nine main factors with the most substantial statistical significance in patients with gangrene and perforation of the gallbladder wall: age >65, male gender, diabetes mellitus, cardiovascular pathology, tachycardia>90 bpm, WBC>14.109, the thickness of gallbladder wall > 4 mm with pericholecystic fluid, ASAT and ALAT > 40 UI, CRP>150 ng/l. The total possible score was 11 points. The positive predictive value of the scale was 96% and identified the cases with micro-perforation and perivesical abbesses among the group with the highest total score.
Porcine or Bovine Tissue Valves: Which are Better for Surgical Aortic Valve Replacement?
Authors: Manchev Georgi G. , Goranovska Valya V. , Stoitsev Georgi Y. , Markov Boyan , Gegouskov Vassil А.
Published: December 2023

The choice between mechanical and bioprosthetic aortic valve implants is affected by relatively clear criteria. However, the choice between porcine or pericardial valve is more complex regarding bioprosthetic devices. We aimed to elucidate any hemodynamic and clinical difference between two widely used bioprosthetic valves: the Sorin Mitroflow bovine pericardial valve and the St. Jude Medical Epic Supra porcine valve. We retrospectively studied 71 consecutive patients separated into two groups based on the valve they received. Clinical outcomes included patient survival and hemodynamic performance of the implanted prostheses. Patients were assessed at one and five years postoperatively. Mean transprosthetic pressure gradients were used as a marker of hemodynamic performance. The Mitroflow valve exhibited lesser mean transvalvular gradients than the Epic valve for all labelled sizes at one and five years postoperatively. The 5-year survival was equal between groups. Both prostheses demonstrated a small but significant increase in mean pressure gradients in the fifth year. Most patients enjoyed significant clinical improvement as assessed by NYHA functional class. Both bioprostheses performed very well with excellent hemodynamic parameters. The pericardial valves are a safe and appropriate choice for surgical bioprosthetic aortic valve replacement.
Squamous Cell Carcinoma of the Skin: Epidemiology, Diagnosis, Management, Recurrence and Mortality Rates for the Bulgarian Population
Authors: Vasilev Preslav P. , Karaivanov Milen P. , Karamanliev Martin P. , Dimitrov Dobromir D. , Troyanova Petranka P. , Yordanova Ivelina A.
Published: December 2023

Squamous cell carcinoma of the skin (SCCs) accounts for 20-30% of non-melanoma skin cancers, resulting in 1 million cases in the United States annually. The risk of developing SCCs increases annually, and this process will likely be continued because of the aging population. We investigated 355 patients with histopathologically confirmed SCCs. We rated the age- and sex-related incidence, risk factors, localisation, pathological features, staging systems and treatment, and the recurrence and mortality rates of the tumours. Staging and risk stratification for recurrence and metastases is significant. Most SCCs are successfully treated surgically, with a small subset of carcinomas leading to recurrence, metastasis, and death. Patients with advanced and metastatic disease are often inappropriate for surgical and radiation therapy. We present the first study on squamous cell carcinoma of the skin conducted for the population of the Pleven and Lovech regions of Bulgaria.
Contact Allergy in Atopic Patients
Authors: Popov Alexander K. , Gospodinova Klimentina D. , Gincheva Veronika H. , Grozeva Daniela T. , Gospodinov Dimitar K.
Published: December 2023

Atopic dermatitis (AD) is a chronic inflammatory disease based on genetic and immune alterations and is part of the atopic symptom complex, including allergic rhinitis, allergic conjunctivitis, and bronchial asthma. A disturbed barrier function facilitates antigen penetration through the skin, with the subsequent development of allergic contact dermatitis (ACD). The gold standard for diagnosing ACD is epicutaneous (patch) testing, also applied to objectify contact sensitization in AD. This study aimed to determine the frequency of contact allergy (CA) among individuals with atopic history and the allergens that caused ACD in those cases. We studied 453 individuals tested in the period 2009-2022. Of these, a subpopulation of 189 individuals with atopic diathesis was identified. A retrospective analysis was used. Using clinical and allergological methods, we divided the tested patients according to sex, age, professional occupation, and areas of the body affected by dermatitis and identified the most common contact allergens that cause positive reactions and ACD. In conclusion, our results highlight the possibility of developing ACD in people with atopic diathesis. As far as we know, our study is the first one in Bulgaria to examine the frequency of contact sensitization in AD patients.
Two Wars for One Life: Verbalisation of Experience During the War
Authors: Koval-Fuchylo Iryna
Published: December 2023

This article examines the oral recollections of Leonida Stanislavivna Panchyk, born in 1939 in Makariv district, Kyiv region, where she has lived all her life. The oral recollections were recorded from February 26 to March 5, 2022, during the beginning of the active phase of the Russian-Ukrainian war. The uniqueness and special value of the presented records lies in the fact that they demonstrate the living life of the Ukrainian narrative tradition. The recorded narrative is a direct reaction to the war. The analysed material and the study of the living situation gave grounds to distinguish the following three groups of reasons that caused the emergence of a memory: characters, events, place. The associative logical sequence of plots in memories is described. All the stories are a child’s memories and primarily describe events that are important to the child. Panchyk’s memories are sustained in one ideological, thematic and genre direction, they are not diluted by other themes or genres.
“I Had No Childhood”: A Trauma History of Deported Ukrainians from Western Boykivshchyna
Authors: Kolomyichuk Oleksandr
Published: December 2023

The article is devoted to the trauma history of Ukrainians from Western Boykivshchyna, part of the Boykivshchyna ethnographical region situated in modern Ukraine. Operation Vistula (1947–1950) was the forced resettlement of more than 150,000 Ukrainians and mixed Polish-Ukrainian families from the territory of Rzeszów, Lublin and Kraków provinces (Voivodeships) to the western and northern territories of Poland, leading to radical changes within this regional group. The article deals with the difficult experience of the resettlers not only in the context of psychological, but also cultural, trauma. According to the theory of Polish sociologist Piotr Sztompka, three main phases of cultural trauma induced by resettlement have been highlighted and are outlined as strategies to cope with trauma: contemporary resettlers’ preservation of native culture, religion and family tradition, and sharing memories of the past.
Kazakh Pregnancy, Childbirth and Childcare Traditions
Authors: Yegizbayeva Meruyert Karpykovna , Karimov Mukhtarbek Karpykovich , Kozgambaeva Gulnara Bestibaevna , Beisegulova Ainur Kydyrgalievna , Soikina Natalya Yurievna
Published: December 2023

The article deals with customs and rituals related to pregnancy, childbirth and childcare among Kazakhs at the end of the 19th and beginning of the 20th centuries, and the preservation and changes in these traditions today. The article is based on written data, as well as field data collected by authors from East Kazakh-stan. The customs of the Kazakh people are connected with those of neighbouring people, including the Turkic-speaking people of Siberia and Central Asia.

The rituals associated with a pregnancy and childbirth have been divided into three main stages: prenatal customs, childbirth customs, and postpartum customs. We analysed the formation of these customs and their semantic meanings. This helps us to identify factors that have influenced and affected women’s position in the family and in society, as well as those factors that led to an increase or decrease in status. Kazakhs have a particular respect for pregnant women, and the status of women who give birth to sons, or to many children, is especially high.
The Baby on the Track: A Newspaper Legend with Roots in the 19th Century
Authors: Klintberg Bengt Af
Published: December 2023

In a novel by a Chinese author, Yu Hua, the birth of the main character takes place in a train toilet. He falls down on the track and survives. During the last 30 years news stories with this content have been reported several times. The event is generally said to have taken place in China or India. From a folkloristic perspective the story can be defined as a newspaper legend. Like contemporary legends in oral tradition newspaper legends often are about accidents where babies are involved. As opposed to the orally transmitted legends they generally have a happy ending; they are published as a counterbalance to all the real accidents that daily papers have to report. The oldest version of “The Baby on the Track” was published in 1888 in a medical journal. The author, the famous physician William Osler, had a reputation for being a practical joker, and today it is difficult to judge if his story is based on a real case or if Osler invented it.
Understanding Hybrid Threats and their Societal Impact – Republic of Moldova Case Study
Authors: Stănescu Marina
Published: December 2023

Hybrid threats undermine societies and foster unrest. Russia’s brutal and unjustified war against Ukraine has changed Moldova’s geopolitical situation. As President Maia Sandu states “using the full range of hybrid threats - including false bomb threats, cyber-attacks, disinformation, calls for social unrest and open corruption – Russia has sought to destabilize the government, erode our democracy and jeopardize Moldova’s contribution to the security of Europe as a whole”. Through consultants, money transfers, and fostering corruption, Russia is interfering in Moldova’s political landscape. However, the international community is highly concerned and supports the Republic of Moldova through a wide range of measures and instruments. The goal of this article is to highlight the main hybrid actions, their impact on Moldovan society, and the state authority’s response in responding to these hybrid threats. Consequently, this article emphasizes the difficulty of ensuring political sustainability amid an intense hybrid warfare.
Pemeriksaan Getaran Struktur dan Rekomendasi Perkuatan untuk Peningkatan Kapasitas Beban dan Pengurangan Getaran
Authors: Khoeri Heri , Alisjahbana Sofia W
Published: December 2023

Suatu gedung yang masih difungsikan harus memenuhi kriteria kelaikan fungsi bangunan baik dari aspek keamanan, kenyamanan, dan pemenuhan standar peraturan yang berlaku sehingga dapat melayani kebutuhan sesuai dengan fungsinya. Adanya perubahan fungsi ruang pada gedung Bank Swasta di Kota Tegal dari ruang kantor menjadi ruang arsip yang dilakukan tanpa mempertimbangkan kekuatan struktur mempengaruhi kinerja struktur tersebut, indikasinya terlihat lendutan pada balok, retakan pada pelat dan getaran yang mengganggu kenyamanan pengguna bangunan. SNI 2847 2019 mensyaratkan lendutan ijin pada pelat beton, SNI 1729 2002 mensyaratkan lendutan ijin balok baja, sementara KMNLH No.49 Tahun 1996 dan ISO 2631-2 1989 mensyaratkan getaran yang tidak merusak bangunan, mengganggu kenyamanan dan kesehatan manusia. Dari hasil uji getar diketahui bahwa getaran pada kondisi operasional melebihi batas yang diijinkan untuk bangunan kantor. Begitu pun dari hasil analisis kondisi eksisting struktur menunjukkan lendutan yang terjadi melampaui batas ijinnya. Untuk mengurangi lendutan dan menambah kekakuan struktur direkomendasikan perkuatan dengan penambahan balok anak dan overlay pelat setebal 6 cm. Sebelum dilakukan analisis perkuatan, frekuensi alami struktur eksisting hasil analisis diverifikasi dengan frekuensi hasil uji getar. Modifikasi pada model struktur dilakukan pada kekakuan elemen dan asumsi tumpuan. Setelah model mendekati kondisi lapangan, dilakukan analisis dan desain perkuatan. Secara analitis perkuatan yang direkomendasikan menaikkan frekuensi dari 4.879 Hz menjadi 8.298 Hz, mengurangi percepatan, kecepatan dan lendutan puncak 80.86%, dan mengurangi lendutan maksimal 66.07% dari kondisi awalnya, sehingga puncak getaran dalam kondisi operasional dan lendutan maksimal memenuhi kriteria yang diijinkan untuk ruang arsip.
PERMASALAHAN DALAM PENYUSUNAN PERENCANAAN PEMBELAJARAN (STUDI KASUS PADA SEBUAH SEKOLAH PAUD DI SERANG)
Authors: Kaenah Wulan Fauzia , Utami Sri Yulia
Published: December 2023

Peraturan Menteri Pendidikan dan Kebudayaan Nomor 137 Tahun 2014 tentang Standar Nasional Pendidikan Anak Usia Dini menyebutkan bahwa salah satu kompetensi yang harus dimiliki seorang guru adalah kompetensi pedagogik, dimana menyusun perencanaan pembelajaran adalah salah satu aspeknya. Penelitian ini dilakukan untuk mengetahui permasalahan yang dihadapi oleh guru ketika menyusun perencanaan pembelajaran dan untuk mengetahui dampak dari permasalahan tersebut terhadap kegiatan pembelajaran. Penelitian ini adalah penelitian kualitatif dengan menggunakan pendekatan deskriptif. Subjek dari penelitian ini adalah dua orang Guru PAUD di salah satu Sekolah di Kabupaten Serang. Teknik pengumpulan data pada penelitian ini adalah menggunakan wawancara, observasi dan juga studi dokumentasi. Hasil dari penelitian ini menunjukan bahwa permaslahan dalam menyusun perencanaan pembelajaran ini adalah penysunan perencanaan pembelajaran yang dirancang oleh guru tidak sesuai dengan tahapan perencanaan yang ditetapkan pada kurikulum. Kurikulum 2013 PAUD menyatakan bahwa perencanaan pembelajaran PAUD terdiri dari Prosem, RPPM dan RPPH, sedangkan Guru hanya menyusun RPPH saja. Dampak dari masalah tersebut adalah sulitnya Guru dalam mengatur anak di kelas. Kesimpulan dari penelitian ini adalah pentingnya mengikuti prosedur yang ditetapkan oleh kurikulum dan perlunya pengawasan dan bimibingan yang kontinyu dalam penyusunan perencanaan pembelajaran.
ANALISIS MANAJEMEN KEUANGAN LEMBAGA PAUD (TK, RA DAN KB)
Authors: Wahyuni Arisna
Published: December 2023

Pengelolaan lembaga pendidikan anak usia dini yang efektif akan berpengaruh pada kualitas PAUD tersebut, kualitas pendidikan anak usia dini secara terus menerus dapat meningkat apabila lembaga PAUD tersebut di kelola dengan baik dan maksimal., terutama dalampengelolaan anggaran atau keuangan. Penelitian ini bertujuan agar manajemen atau pengelolaan keuangan di lembaga PAUD dapat meningkatkan kefektifiasan dalam menggunakan keuangan di lembaga sekolah, selain itu juga dapat meminimalisir penyalahgunaan keuangan sekolah. Penelitian ini menggunakan penelitian kualitatif, penelitian ini bersifat kepustakaan (library research), yang mana sumber utama dalam penelitian ini berasal dari buku dan studi literature-literatur terdahulu.. Hasil dari penelitian ini adalah bahwasanya biaya di lembaga pendidikan anak usia dini di peroleh dari beberapa sumber yaitu, pemerintah, masyarakat, orang tua peserta didik itu sendiri. Peneglolan keuangan yang di lakukan di lembaga PAUD ada beberapa tahap yaitu; merencenakan anggaran tahunan, pengadaan anggaran, mendistribusian anggaran tersebut, melaksanaan anggaran yang telah direncanakan, membukukan keuangan untuk laporan, mengadakan pengawasan terhadap pengelolaan keuangan serta dapat mempertanggungjawabkan pelaporan keuangan tersebut.
PENERAPAN METODE KAISA PADA PENGHAFAL SURAH-SURAH PENDEK PADA ANAK USIA DINI DI TK BUNDA ISNAINI MAWARDI MEDAN
Authors: Hasibuan Yuli Anisah , Masri Dedi , Hasibuan Afrah Nadhilah , Pitriana Eka Riski
Published: December 2023

Summary: : Is Talaqi not interested enough Student because Impressed Boring And Easy to lost Method kingdom? The Method Currently Learned Must Be Adapted With Aim Which Is Desired Method Which Related Wite Al-Qur'an Kindly Special Rote Present As A Solution Since This Method Not Only Gives Understanding Or Just Speaks Text, But Also Uses Action That Proceeds And Given Name With Read Means Simplex Which Actually Thing This Make. Once more students, simply remember that the goal of learning this is for full application. For kindergarten, Kaisa ISNAINI MAWARDI, MOTHER Learn How To Get Information Using A  Qualitative Approach. By Element In Application Approach Imperial On Al-Qur'anic Type Of Ingredient. Study This Including In Category Studies Case, that is, Study This Show Case genuine in present context. Kaisa Will Use This Method. BUNDA ISNAI MAWARDI use software in.TK to arrange the syllabus. Using empirical methods, RPP uses the Kaisa method for process learning and performs an evaluation for subsequent repair learning. Support consists of encouraging students to learn, creating a pleasurable learning environment, and addressing any barriers to learning, such as the need for preparation and students' inresidence Yangs' lack of understanding of some imperial methods
University student's knowledge of childhood hearing loss in Gulf Cooperation Council countries
Authors: Albeshi Saeed , Alqhtani Muhanned , AlJohani Mohammed , Rumaihi Abdulla , Al-Mamari Malak , Khorsheed Sara , Hussain Shahad , Alqallaf Shaikhah , balushi Amna , Albishi Fayez , Alruwaili Rayan , Mansour Arwa , Elamin Abdelaziz
Published: December 2023

Objective:
This study sought to evaluate medical students\' current understanding of childhood hearing loss in the Gulf Cooperation Council (GCC) nations of Saudi Arabia, Bahrain, Kuwait, and the Sultanate of Oman.
Methods:
A cross-sectional study was conducted in multiple GCC countries. Non-probability convenient sampling was used to recruit participants through e-mails and social media platform including WhatsApp. An online questionnaire was distributed to medical and health science students in four medical schools in GCC countries regarding knowledge towards childhood hearing loss.
Results:
A total of 791 participants were enrolled in this study. The participants were of 18-30 years age bracket. Most of the participants (69%) were females. Majority of them (81%) were single; and rest (19%) were married. The study revealed that many participants (62%) were not well-informed about hearing loss.
Conclusion:
Majority of the participants have limited knowledge towards childhood hearing loss.
Public Awareness of Early Symptoms of Acute Myocardial Infarction in Arar, Saudi Arabia
Authors: Alharbi Mohammed , Alanazi Ghadah , Almesned Bishri , Alenazi Yasmin , Alruwaili Raghad , Alanazi Wafa , Alshammari Shuruq , Alanazi Ahad , Alenezi Shahad , Almohaimeed Ashjan
Published: December 2023

Background: A significant factor in patient delays is a lack of understanding of MI symptoms. Denial, fear, and an undue reliance on self-management could be the causes of more delays. This study aimed to assess the level of public awareness concerning the early symptoms of acute myocardial infarction (MI) and the appropriate actions to be taken when these symptoms manifest in the population of Arar, Saudi Arabia.

Methods: A cross-sectional design employing a quantitative approach was used. Data were collected through an online self-administered questionnaire distributed to 390 participants using convenience sampling. The collected data were analyzed using descriptive and inferential statistics.

Results: The study revealed mixed awareness levels among participants. While 63.6% correctly recognized chest pain as a symptom of MI, only 61.8% identified radiating pain to the shoulder, arm, back, neck, and jaw as an alarming symptom. Additionally, 74.9% recognized shortness of breath, and 64.6% identified fatigue as potential MI symptoms. Other symptoms, such as cold sweats (57.2%) and nausea (40.3%), were less well-known. Among the recognized risk factors, smoking (86.7%), diabetes (64.1%), and hypertension (79%) were relatively well-acknowledged, while obesity (84.4%) and sedentary lifestyles (86.9%) were recognized to a lesser extent. Age, education, income, city of residence, personal or family history of MI, history of MI among acquaintances, and exposure to AMI information in media and books significantly influenced awareness scores (p < 0.05).

Conclusion: The study underscores the importance of tailored public health interventions to enhance MI awareness, especially among younger individuals, those with higher education, and those with lower incomes. It highlights the need for addressing lesser-known risk factors, such as obesity and sedentary lifestyles, to comprehensively prevent MI.
The general population's knowledge and awareness of smoking as a risk factor for urological diseases in the Western Region of Saudi Arabia
Authors: Albarakati Hussain , Alomairi Mohanned , Saati Bassam , Alharthi Fahad , Alshaikh Mutaz , Alhothali Ammar , Nmnkany Abdulkareem , Khafagy Abdullah
Published: December 2023

Background:
In Saudi Arabia, smoking is a significant public health concern. Cigarette smoking is the leading preventable cause of urinary bladder cancer and increases the risk of prostatic and renal malignancies. There have been a limited number of studies conducted on this topic in Saudi Arabia, especially in the Western Region.
Objectives:
The current study aims to assess the knowledge and awareness of the general population in the Western Region of Saudi Arabia regarding smoking as a risk factor for urological diseases.
Methods:
A cross-sectional study was conducted between February and October 2023, employing an online survey self-administered and disseminated through social media platforms. A method of sampling by convenience was utilized to enlist the participants for the study. Following approval from an Institutional Review Board, information was gathered from Saudi Arabian citizens and residents aged 18 or older residing in the western region.
Results:
The study included a total of 850 individuals. Based on the gender distribution, 67% of the individuals were male, while 33% were female. The participants were surveyed regarding their smoking habits; out of the total, 70% identified as non-smokers, 18% identified as smokers, and 12% identified as ex-smokers. 37% of respondents acknowledged that smoking posed a risk for bladder cancer, while 36.8% acknowledged that smoking posed a risk for kidney cancer. Gender exhibited a notable correlation with kidney cancer and erectile dysfunction (p < 0.05). Moreover, there was a strong correlation between smoking status and erectile dysfunction (p < 0.05).
Conclusion:
The study revealed that only a small proportion of participants have sufficient knowledge of the association between smoking and the heightened susceptibility to kidney and bladder cancer. Therefore, it is necessary to increase awareness through the implementation of campaigns and the utilization of social media channels.
Update on the Law Regarding the Control of Minimarket to Protect Small Retailers
Authors: Indrajaya Indrajaya , Tanzili Mulyadi
Published: December 2023

The increase in the establishment of minimarkets has implications for micro and small business actors, including owners of grocery stores and stalls that sell goods similar to minimarkets. Whereas this business sector is the largest in contributing to the Indonesian national economy. One of the factors causing the increase in the establishment of minimarkets is the regulation made by the government in the form of laws, government regulations, presidential regulations and ministerial regulations that provide convenience in the establishment of minimarkets. Therefore, it is necessary to have legal arrangements in regulating the increase in the establishment of minimarkets in order to protect micro and small businesses. This Journal writing uses normative legal research methods using primary legal materials and secondary data obtained through library data. The results showed that there was an impact of the existence of minimarket outlets on the income of retail traders and grocery stores experiencing changes in income. the traders experienced a decrease in turnover and the amount of income per day. The implication becomes the basis for the formation of the concept of new rules in maintaining business balance as an effort to protect the business actors of Grocery Stores and Stalls from the rampant establishment of Minimarket in the form of a review of the articles related to the existence of Minimarket adjacent to residential areas and fill the legal vacuum related to the distance setting of Minimarket establishment with other Minimarket as well as restrictions on granting business licenses, setting working hours and setting administrative sanctions.
Special vocabulary of the Russian sublanguage of social work in the stratification aspect
Authors: Mezit Anna Eduardovna , Kattsina Tatyana Anatolevna
Published: December 2023

The article examines the vocabulary of the Russian sublanguage of social work from the standpoint of stratification terminology, identifies and characterizes the varieties of terminological vocabulary, as well as special names functioning in the lower case of the sublanguage. The object of the study is the sublanguage of social work employees. The subject of the study is the lexical composition of a special sublanguage of social work. The following methods were used in the course of the study: the method of selective receipt of special texts, the sociolinguistic method, the functional-semantic method and the method of linguistic description. The author considers the studied vocabulary from the standpoint of genesis, formal-structural criterion, motivation, on the basis of correlation with logical categories. The results of the study identified stratification categories of special vocabulary of the Russian sublanguage of social work, carried out the classification of special units by genesis, from the standpoint of formal structural criteria, on the basis of motivation and correlation with logical categories. It is revealed that the key functions of the special vocabulary in the studied sublanguage are nominative and cognitive. In the course of the research, the conclusion is made about the "maturity" of the special vocabulary of the sublanguage of social work and its high linguistic informativeness. The scientific novelty of the research lies in the fact that for the first time (within the framework of the problems of modern linguistics) a comprehensive analysis of the vocabulary of the Russian sublanguage of special work was carried out, stratification categories of professional vocabulary of the sublanguage of social work were identified.
E. F. Rosen against Slavophilism: two articles on the "Moskovsky sbornik" of 1847
Authors: Kuts Nikolai Viktorovich
Published: December 2023

The subject of the study is the perception by Baron E. F. Rosen - poet, playwright and critic, author of the libretto for the opera by M. I. Glinka "Life for the Tsar" (1836) - of the ideas of Slavophilism and pan-Slavism in the second half of the 1840s. The object of the study was two anonymous reviews of the Slavophile "Moscow Literary and Scientific Collection", published in 1847, the authorship of which was announced by Rosen himself during a printed discussion with S. P. Shevyrev about N. V. Gogol's book "Selected passages from correspondence with Friends" published in the same year. Other printed works by Rosen on the pages of the newspaper "Severnaya Pchela" and the magazine "Son of the Fatherland" are also used as material. The main research methods are hermeneutical and cultural-historical. Rosen's texts are considered in connection with the socio-political situation of the 1840s. The scientific novelty of the study lies in the introduction into scientific circulation of two texts not previously attributed to Rosen. The main conclusions of the study are as follows: 1) in 1847 Rosen treated the ideas of Slavophilism and pan-Slavism sharply negatively, but in 1848, apparently, against the background of news about revolutions in Western Europe, he drew closer to the Slavophiles in reasoning about the special beginning of the Russian people, "an unthinking sense of morality" opposed to Western European rationalism; 2) Rosen's differences with the Slavophiles were explained by his enlightening Westernism based on N. M. Karamzin and A. S. Pushkin; 3) the official ideology of the Nicholas reign imposed a certain imprint on Rosen's views; 4) the baron assigned a powerful civilizing role to the autocratic government.
The Anti-Anginal Efficacy of Bosentan in the Coronary Slow Flow Phenomenon
Authors:   School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5000, Australia, Kopetz Victoria , Tavella Rosanna ,   School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5000, Australia, Pasupathy Sivabaskari ,   School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5000, Australia, Horowitz John ,   School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5000, Australia, Beltrame John ,   School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5000, Australia
Published: December 2023

Background: The Coronary Slow Flow Phenomenon (CSFP) is a coronary microvascular disorder that presents with recurrent angina for which there is no available effective therapy. The vasoconstrictor Endothelin-1 (ET-1) has been implicated in the pathophysiology of the CSFP. This study aimed to determine whether the ET-1 antagonist (Bosentan) is effective in ameliorating angina symptoms in CSFP patients. Methods: Using a randomised, double-blind, placebo-controlled, cross-over trial methodology, the anti-anginal efficacy of Bosentan 125mg bd was assessed in 23 patients with symptomatic CSFP. Study endpoints were measured following 4 weeks of therapy with the primary endpoint being angina frequency. Secondary endpoints included (1) clinical measures of angina and health status, (2) endothelial function parameters, and (3) inflammatory and oxidative stress markers. Results: There was no statistically significant reduction in angina frequency with Bosentan therapy compared to placebo (median angina episodes/4weeks [25-75% IQ]: Bosentan 14[5,36] vs Placebo 25[9,55]) although a trend for improvement in symptoms during the Bosentan phase was observed. Furthermore, Bosentan did not impact on any of the secondary endpoints compared with placebo. Conclusion: Bosentan did not have a major impact on angina frequency in patients with the CSFP. A small anti-anginal effect cannot be excluded and requires a larger trial.
The Anti-Anginal Efficacy of Bosentan in the Coronary Slow Flow Phenomenon
Authors:   School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5000, Australia, Kopetz Victoria
Published: December 2023

Background: The Coronary Slow Flow Phenomenon (CSFP) is a coronary microvascular disorder that presents with recurrent angina for which there is no available effective therapy. The vasoconstrictor Endothelin-1 (ET-1) has been implicated in the pathophysiology of the CSFP. This study aimed to determine whether the ET-1 antagonist (Bosentan) is effective in ameliorating angina symptoms in CSFP patients. Methods: Using a randomised, double-blind, placebo-controlled, cross-over trial methodology, the anti-anginal efficacy of Bosentan 125mg bd was assessed in 23 patients with symptomatic CSFP. Study endpoints were measured following 4 weeks of therapy with the primary endpoint being angina frequency. Secondary endpoints included (1) clinical measures of angina and health status, (2) endothelial function parameters, and (3) inflammatory and oxidative stress markers. Results: There was no statistically significant reduction in angina frequency with Bosentan therapy compared to placebo (median angina episodes/4weeks [25-75% IQ]: Bosentan 14[5,36] vs Placebo 25[9,55]) although a trend for improvement in symptoms during the Bosentan phase was observed. Furthermore, Bosentan did not impact on any of the secondary endpoints compared with placebo. Conclusion: Bosentan did not have a major impact on angina frequency in patients with the CSFP. A small anti-anginal effect cannot be excluded and requires a larger trial.
Single-particle photoluminescence measures a heterogenous distribution of differential circular absorbance of gold nanoparticle aggregates near constricted thioflavin T molecules
Authors: Chattopadhyay Saaj , Lipok Maciej , Pfaffenberger Zechariah , Olesiak-Bańska Joanna , Biteen Julie
Published: December 2023

The chirality of biomacromolecules is critical for their function, but the optical signal of this chirality is small in the visible range. Plasmonic nanoparticles are antennas that can couple to this chiral signal. Here, we examine the molecular-scale mechanism behind the induced circular dichroism of gold nanorods (AuNRs) in a solution with insulin fibrils and the fibril-intercalating dye thioflavin T (ThT) with polarization-resolved single-molecule fluorescence and single-particle photoluminescence (PL) imaging. We compared the PL upon excitation by left- and right-handed circularly polarized light to calculate the differential absorbance of AuNRs near insulin fibrils with and without ThT. Overall, our results indicate that AuNRs do not act as chiral absorbers near constricted ThT molecules. Instead, we hypothesize that fibrils promote AuNR aggregation, and this templating is mediated by subtle changes in the solution conditions; under the right conditions, a few significantly chiral aggregates contribute to a large net circular dichroism.
Efficient Access to Skipped Dienes and Trienes by Cobalt-Catalyzed Reductive Coupling of Alkynes and Allenyl Carbonates
Authors: Cavallo Luigi , Sundararaju Basker , Pradhan Subhankar , Satav Dhananjay , Dutta Sayan , Maity Bholanath
Published: December 2023

Skipped dienes is one of the most prevalent motifs in vast array of natural products, medicinal compounds, and fatty acids. Herein, we disclose a straightforward one-step reductive protocol under Co/PC for the synthesis of diverse 1,4-dienes with excellent regio- and stereoselectivity. The protocol utilize allenyl carbonate as 1,3-butadiene surrogate and providing a synthetic tool to access skipped diene in one step with alkyne under dual-catalytic approach. Further, large variety of alkynes including terminal alkynes, propargylic alcohols and internal alkynes were employed. The homologation of natural terpenols into synthetic terpenols by iterative allylation of four-carbon allyl units resulted in bio-mimetic synthetic terpenes derived from propargylic alcohols. Under this approach the programmed skipped diene can be accessed with predictable stereochemistry and might be a useful synthetic method for targeted synthe-sis. The experimental studies, control experiments and detailed DFT studies revealed that the 1,3-diene generated in situ from allenyl carbonate, diisopropyl ammonium act as proton source, Co(II)-π-allyl species involved in the catalytic cycle and the mechanism proceed through Co(II)−Co(I)−Co(III) pathway.
A rapid and scalable method for visible light induced bromination of uracil derivatives in falling film looping photoreactor
Authors: Das Subrata , Naskar Shibu , Mal Susital , - Shivangi
Published: December 2023

A looping falling film reactor protocol was applied for the visible light induced green synthesis of 5-bromouracil derivatives using N-bromosuccinimide (NBS). Readily available cool white LEDs of emission spectrum 400 nm to 700 nm were used. A minimum of 2.2 equivalent NBS was required to reach the maximum yield. Nonhazardous solvent acetonitrile was found to be most effective compared to other solvents. This methodology has also shown excellent tolerance with various 6-substituted and N-substituted uracil. We successfully synthesized sixteen novel 5-bromouracil and pyrimidine derivatives and characterized them using various spectroscopic methods such as 1H-NMR, 13C-NMR, HRMS, and SC-XRD. Finally, the reaction between 6-chloro-3-methyluracil and NBS was used in three different reactor modules of looping falling film reactor to show the successive scalability of the process with comparable photonic characteristics and reaction conditions. We achieved milligram to multigram scale reaction with almost equal efficiency and maximum productivity up to 1.2 kg/day.
OTİZM SPEKTRUM BOZUKLUĞU OLAN ÇOCUKLARIN EĞİTİMİNDE AİLE KOÇLUĞU
Authors: GICI VATANSEVER Aynur , AHMETOĞLU Emine
Published: December 2023

Otizm Spektrum Bozukluğu (OSB) zihinsel yetersizlikten sonra en yaygın yetersizlik türü olarak açıklanmaktadır. Bu durum, otizmin nedenlerinin ortaya konulmasının, olası önleme yollarının belirlenmesinin ve daha da önemlisi çocuk-aile eğitiminin önemini ve ihtiyacını açıkça ortaya koymaktadır. OSB tanısı olan çocuklarda erken ve yoğun davranışsal müdahale en etkili müdahale biçimidir. Bu kapsamda nitelikli ve işlevsel erken ve yoğun özel eğitim verebilmek ancak aile işbirliği ile mümkün olmaktadır. Alanyazında erken müdahalenin özel eğitimciler ve aile üyeleri tarafından sunulması erken müdahale programlarını çeşitlendirip zenginleştirdiği gibi öğrenilen becerilerin genellenme olasılığını da arttırmaktadır. OSB tanılı çocuklarının eğitimine katılımlarını sağlayabilmek için ailelere sunulan yetişkin öğrenme yollarından biri koçluk uygulamalarıdır. Koçluk uygulamaları, ailelere sunulduğunda aile koçluğu adını almaktadır. Aile Koçluğu modelinde aile ve uzman arasında tecrübe ve bilgi alışverişi yapılmaktadır. Bu modelde süreç, danışmanlık alan ve koçluk yapan uzmanın ortak planlama yapması, ortak hedef belirlemesi, koçun bilgi sunması, danışanın uygulama pratiği ve koçun uygulama pratiklerine geri bildirim vermesi şeklinde ilerler. Ek olarak, çalışmada aile koçluğunun uygulandığı araştırmaların bulguları ışığında uygulama ve araştırma öneriler de sunulmuştur.