bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor lysis syndrome in paediatric cancer patients
Authors: Morshed AKM Amirul , Islam Shahnoor
Published: November 2023

Introduction: Tumor lysis syndrome (TLS) is a common complication of malignancies and can result in renal failure or death.

Review: In paediatric tumor with a high proliferative rate and relatively large mass and a high sensitivity to cytotoxic agents, beging of therapy often results in the rapid release of intracellular metabolic products of proteins and nucleic acids into the bloodstream. Raised concentrations of uric acid, phosphates, potassium and urea can overwhelm the body’s homeostatic mechanisms to excrete these materials and result in the clinical spectrum associated with TLS. Clinical features include gastrointestinal disturbances, neuromuscular effects, cardiovascular complications, acute renal failure and death. The incidence of clinical TLS is approximately 6% for acute leukemias and 10% for lymphomas. Pediatric cancers are the leading cause of death by disease in children. The most common pediatric cancers include the leukemias, lymphoma, Wilms’ tumor and neuroblastoma. Thus, TLS prevention and treatment is a multidisciplinary approach involving the collaboration of medical oncologists/ hematologists and nephrologists has role for optimal patient outcomes. Rehydration is fundamental in the management of TLS. For hyperuricemia we may use allopurinol. Conclusion: The early diagnosis and treatment of metabolic abnormalities prevents the severe complications of tumor lysis syndrome.

Journal of Paediatric Surgeons of Bangladesh (2016) Vol. 7 (2): 55-60
Antología de poesía cuencana modernista
Authors:   Universidad del Azuay, Verdugo-Cárdenas Jackelin
Published: November 2023

La Fiesta de la Lira, fundada en 1919 por Remigio Crespo Toral, se convirtió en el epicentro cultural de Cuenca, promoviendo la literatura y las artes. Poetas de tres generaciones se reunieron en este evento: la segunda generación de 1864, la primera de 1894 y la primera generación de 1924. La literatura cuencana experimentó cambios tras la era liberal, con nuevas tendencias estéticas y una producción lírica que abarcó temas como la Virgen de Mayo, la noche, la naturaleza y lo criollo.
UDA - ERP para PYMES Módulo de inventarios y manufacturas
Authors:   Universidad del Azuay, Astudillo-Rodríguez Catalina , Maldonado-Matute Juan ,   Universidad del Azuay, Crespo Martínez Esteban ,   Universidad del Azuay, Erazo-Garzón Lenin ,   Universidad del Azuay
Published: November 2023

Este proyecto surge como una solución innovadora y accesible para las MIPYMES, así como para emprendedores y artesanos de la región. Estos grupos, a menudo limitados por recursos económicos y la etapa inicial de sus negocios, se benefician de esta solución tecnológica desarrollada por la Universidad del Azuay. Este enfoque se centra en la gestión de operaciones mediante sistemas de Planificación de Recursos Empresariales (ERP), que integran diversas áreas funcionales. Estos ERP permiten simplificar la gestión de información, reemplazando el papeleo con eficiencia. Este libro sirve como guía para comprender y aplicar esta herramienta, con un enfoque accesible y apoyo técnico. ¡Impulsa tu eficiencia y éxito empresarial!
UDA - ERP Para PYMES Módulo de inventarios y manufacturas
Authors:   Universidad del Azuay, Astudillo-Rodríguez Catalina , Maldonado-Matute Juan ,   Universidad del Azuay, Crespo Martínez Esteban ,   Universidad del Azuay, Erazo-Garzón Lenin ,   Universidad del Azuay
Published: November 2023

Este libro forma parte de los tres tomos que resumen el desarrollo de la primera etapa del proyecto de desarrollo de un Software ERP realizado en la Universidad del Azuay para las MIPYMES del Ecuador, orientado a los módulos de inventarios y manufactura. En este documento, encontrarás dos secciones clave. La primera detalla los productos resultantes de la fase de análisis y diseño de los módulos de administración, manufactura e inventarios, siguiendo las pautas del estándar IEEE 830. La segunda sección ofrece una guía metodológica para llevar a cabo pruebas de software, utilizando como ejemplo el Sistema UDA-ERP para Pymes, un proyecto desarrollado en la Universidad del Azuay como parte de su investigación.
UDA - ERP Para PYMES Módulo de inventarios y manufacturas
Authors:   Universidad del Azuay, Astudillo-Rodríguez Catalina , Maldonado-Matute Juan ,   Universidad del Azuay, Crespo Martínez Esteban ,   Universidad del Azuay, Erazo-Garzón Lenin ,   Universidad del Azuay
Published: November 2023

Este libro forma parte de los tres tomos que resumen el desarrollo de la primera etapa del proyecto de desarrollo de un Software ERP realizado en la Universidad del Azuay para las MIPYMES del Ecuador, orientado a los módulos de Manufactura e Inventarios. Este trabajo se enfoca a i) establecer una guía de pruebas de penetración basada en herramientas para este efecto, y ii) documentar las pruebas de penetración realizadas al software UDA-ERP para PYMES, que se viene desarrollando en la Universidad del Azuay.
Presagios de la vida en Nosgoth
Authors:   Universidad del Azuay, Bermeo Juan Fernando
Published: November 2023

Apreciación de Antonio González Arteaga "Al poner un pie en el pórtico de Presagios de la vida en Nosgoth , de Juan Fernando Bermeo, inmediatamente uno reconoce un bello homenaje a la fantasía y al terror literario que sirven de inspiración a las obras que, a su vez, lo inspiran a él, pero basta con cruzar el umbral para ver tocados los nervios abiertos del horror que supera al fantástico y al sobrenatural; aquel horror subyacente y cotidiano; aquel horror de los vampiros que acechan a plena luz del día, como lo han hecho siempre alimentándose, si, de sangre, aunque también de sudor, de ignorancia, de sufrimiento y de conformismo. Es pues Nosgoth en verdad el país de todos; el tuyo, el mío, y el de lobos, corderos y vampiros. 136 páginas
Hunting for the Uralic accusative(s)
Authors: Holopainen Sampsa
Published: November 2023

Besprechung
Honti, László. 2022: Az ősi uráli tárgyragok története és vesszőfutása: Accusatum et expulsum. Budapest: Tinta Könyvkiadó. 283 pp.
The largest bidirectional dictionary of North Saami and Swedish to date
Authors: Kejonen Olle
Published: November 2023

Besprechung
Svonni, Mikael. 2023. Davvisáme­giela-ruoŧagiela, ruoŧagiela-davvi­sámegiela sátnegirji = Nordsamisk-­svensk, svensk-nordsamisk ordbok. Kiruna: Ravda Lágádus. 503 pp.
Strategi Pengembangan Investasi Industri Semikonduktor Di Indonesia
Authors: Nurhayati Ely , Angdreas Kevin
Published: November 2023

Industri semikonduktor telah berkembang menjadi primadona seiring dengan meningkatnya permintaan dan penggunaan produk konsumen elektronik. Melihat terbatasnya produsen semikonduktor dunia serta gesekan hubungan dagang di antara dua pemain utama industri semikonduktor dunia, yakni Amerika Serikat (AS) dan Tingkok, Tingkok dan Taiwan, serta Korea Selatan dan Korea Utara, maka peluang Indonesia untuk mewujudkan industri semikonduktor dalam negeri dan ikut serta dalam rantai nilai global masih sangat potensial. Metode yang akan digunakan untuk menjawab tujuan dalam penelitian ini adalah metode analisis kualitatif. Adapun metode pengumpulan data yang digunakan dalam penelitian ini adalah melalui wawancara dan FGD (focus group discussion). Pengembangkan investasi industri semikonduktor di dalam negeri memerlukan keseriusan kolektif yang besar dari berbagai pihak. Baik keseriusan dari pemerintah sebagai pengambil kebijakan, masyarakat, dunia industri, maupun akademisi. Upaya pengembangan investasi industri semikonduktor juga membutuhkan waktu yang cukup panjang, sehingga diperlukan strategi jangka pendek maupun jangka panjang. Setidaknya ada empat aspek yang perlu diperhatikan dalam pengembangan investasi industri semikonduktor, yaitu aspek regulasi, SDM, infrastruktur dan ekosistem, serta investasi.
Twenty-Five Years of Resilience
Authors: Zaimah Nely Rahmawati
Published: November 2023

In the aftermath of the tumultuous events 1998, the Sarang Subdistrict in Indonesia experienced profound socio-cultural transformations. This study examines the lasting impacts of that unforgettable year on Sarang's Christian Chinese community, known for its strict religious culture, including numerous pesantrens and influential figures who shape its cultural identity. The study uses qualitative methods to conduct in-depth interviews with six Chinese individuals who have chosen Sarang as their residence. The goal is to explore the significant links between the 1998 tragedy and the transformation of the Chinese ethnic landscape. The study also investigates whether the psycho-cultural phenomenon of identity reconstruction and assimilation, as described by participants, plays a role in these changes. Thus, it offers insights into broader societal dynamics within the country.
İş Sağlığı ve Güvenliği Açısından Türkiye’deki Riskli Sektörlerin Belirlenmesi
Authors: BİLİM Atiye , BİLİM Niyazi , DÜNDAR Sertaç
Published: November 2023

Sağlıklı ve güvenli bir çalışma ortamında çalışmak tüm çalışanların en temel hakkıdır. Gelişen teknoloji ile çalışma ortamındaki tehlike ve riskler çeşitlenerek artmaya devam etmektedir. Bazı sektörler doğası gereği daha fazla tehlike ve buna bağlı riskleri barındırmaktadır. Çalışma ortamındaki risklerin çokluğu ve/veya çalışma ortamında alınması gereken tedbirlerin yetersizliği nedeniyle, bazı sektörlerde kişi başına düşen iş kazası oranı çok yüksek olmaktadır. Sosyal Güvenlik Kurumu (SGK) istatistik yıllıklarında 88 adet ekonomik faaliyet sınıflaması yer almaktadır. Bu çalışmada, Türkiye’de 2017-2021 yılları arasında meydana gelen iş kazaları ve meslek hastalıklarının sektörel dağılımı araştırılmıştır. SGK tarafından sunulan yıllık iş kazası ve çalışan sayısı verilerinden faydalanılarak kaza olabilirlik oranları belirlenmiş ve sektörlerin iş kazaları açısından risk seviyeleri tespit edilmiştir. Kişi başına düşen iş kazası oranı yüksek olan sektörler belirlenmiş ve güvenlik durumları değerlendirilmiştir. Kaza olabilirlik oranına göre birinci sırada “Kömür ve linyit çıkartılması”, ölümlü kaza olabilirlik oranına göre “Su yolu taşımacılığı” , meslek hastalığı olabilirlik oranına göre ise, “Kömür ve linyit çıkartılması” sektörü gelmektedir. Bu çalışma ile iş sağlığı ve güvenliği açısından acil önlem alınması gereken sektörler tespit edilmiştir. Riskler doğru tespit edildiğinde, iş kazaları ve meslek hastalıklarından kaynaklı maddi ve manevi kayıpların önüne geçilmesi sağlanacaktır.
Adli Toksikoloji Laboratuvarlarında Olası Kimyasal Tehlikeler ile İş Sağlığı ve Güvenliği Açısından Alınması Gereken Önlemler
Authors: ÜNEL Feyza , YILDIZ Zehra
Published: November 2023

Bu çalışmada, alkol, uyutucu-uyuşturucu, ilaç etken maddeleri, pestisitler ve hızlandırıcı maddelerin analizlerinin yapıldığı adli toksikoloji laboratuvarlarındaki olası kimyasal tehlikeler belirlenmiştir. Bu tehlikeler, delil niteliğinde olan biyolojik veya kimyasal materyallere temas, materyallerin analizinde kullanılan çözücüler ile çeşitli kimyasal maddelere maruziyet, uyutucu uyuşturucu, uyarıcı maddeler ile ilaç etken maddeleri ve pestisitlerin sertifikalı referans maddelerinin suistimal edilmesi (kötüye kullanımı ya da özkıyım vb. amaçlarla alınması), peroksit oluşturabilen kimyasal maddelerin kullanım sürelerinin bilinmemesi, laboratuvarda kullanılan cihazların gaz silindirlerinin uygunsuz fiziksel koşullarda bulunması, kimyasal maddelerin uygun depolanmaması, kimyasal maddelerin güvenlik bilgi formlarının incelenmemesi ve laboratuvar analiz prosedürlerini uygulama konusunda yetersizliklerdir. Adli toksikoloji laboratuvarındaki olası kimyasal tehlikeler belirlenip, analiz edilmeli, bu tehlikelerin ortadan kaldırılması ya da tehlikenin en az seviyede tutulması için laboratuvar güvenliği sürekli olarak sağlanmalı ve yetkili kişilerce alınan önlemler düzenli olarak denetlenmelidir.
An Assessment of Occupational Accidents and Diseases Among Female Healthcare Personnel in Human Health Services
Authors: IŞIK DEMİRARSLAN Elif , DEMİRARSLAN Kazım Onur
Published: November 2023

This study was designed as a cross-sectional descriptive investigation with the objective of referencing previous research by disclosing the incidence of occupational accidents and occupational diseases among female personnel employed in human health services in Turkey. The study analyzed data from the Social Security Institution of the Republic of Turkey spanning the years 2013 to 2020. The research findings indicate that female healthcare workers experience a greater incidence of occupational accidents and illnesses compared to their male counterparts. Nevertheless, male healthcare workers exhibit a higher mortality rate resulting from work-related accidents. In contemporary times, there has been a decline in work-related accidents and fatalities, as well as occupational illnesses, among women employed in various industries. However, there has been a notable rise in work-related accidents and fatalities, as well as occupational illnesses, among female healthcare professionals.
Effects of Injector Configuration on the Detonation Characteristics and Propulsion Performance of Rotating Detonation Engine (RDE)
Authors: Koo In-Hoi , Lee Keon-Hyeong , Kim Min-Su , Han Hyung-Seok , Kim Holak , Choi Jeong-Yeol
Published: November 2023

Fuel injection and mixing affect the characteristics of detonation initiation and propagation, as well as the propulsion performance of rotating detonation engine (RDE). A study on the injector is carried out in the present investigation. A rectangular-shaped hole-type fuel injector (RHFI) and slit-type fuel injector (SFI) were designed and compared experimentally at equivalent conditions. The investigation of the detonation propagation modes and the analysis of propulsion performance were carried out using fast Fourier transform (FFT), short-time Fourier transform (STFT), and unwrapped image post-processing. Under 50, 75, and 100 g/s flow rate conditions at an equivalence ratio of 1.0 ± 0.05, the RHFI has relatively stable detonation propagation characteristics, higher thrust, and specific impulse performance. Additionally, the results of the experiment indicate that the number of detonation waves affects performance.
Predictions of Programmed Cell Death Ligand 1 Blockade Therapy Success in Patients with Non-Small-Cell Lung Cancer
Authors: Gupta Taksh , Qawasmeh Tamara , McCalla Serena
Published: November 2023

Lung cancer is responsible for the most cancer deaths worldwide, with non-small-cell lung cancer (NSCLC) making up 80% of cases. Some genetic factors leading to NSCLC development include genetic mutations and Programmed Cell Death Ligand 1 (PD-L1) expression. PD-L1 proteins are targeted in an NSCLC treatment called PD-L1 blockade therapy (immune therapy). However, this treatment is effective in a low percentage of patients. This study aimed to create machine learning models to use features, like the number of mutations and the number of PD-L1 proteins in cancer cells, along with others, to predict whether a patient will receive clinical benefits from immune therapy. This was carried out by downloading and merging datasets from cbioportal.org to create a sample size for the model. Features that were highly correlated with clinical benefits were identified. Three machine learning models (Gaussian naïve Bayes, decision tree, and logistic regression) were created using these features to predict clinical benefits in patients, and each model’s accuracy was evaluated. All three models had accuracy rates between 55 and 85%, with two of the models averaging an accuracy rate of around 75%. Doctors can use these models to more accurately predict whether immune therapy treatment is likely to work in a patient before prescribing it to them.
Knowledge and Attitudes toward First Aid among Medical and Nursing Students at Taibah University in Madinah City, Saudi Arabia: A Cross-Sectional Study
Authors: Albadrani Muayad Saud , Qashqari Abdulmajeed Mohammed , Alqelaiti Basel Abdulmonem , Hammad Ohud Khalid , Hammad Raghad Khalid , Alrehely Maram Salamah , Almeshhen Walaa Abdulrahman , Albadawi Emad Ali
Published: November 2023

Objective: The objective of this study is to evaluate the first aid (FA) knowledge, practice, and attitude of medical and nursing students at Taibah University in Madinah. Methods: The study involved a cross-sectional online survey of 359 students from different academic years, using a revised and validated questionnaire on FA procedures, which were assessed utilizing a revised iteration of a questionnaire that had been previously validated. Results: Regarding the knowledge score outcomes, the median score was 4, with an interquartile range of (3,5). Approximately 32.3% of participants demonstrated an excellent level of knowledge in first aid. Age exhibited a substantial and positive correlation with knowledge scores (p < 0.001), no significant correlation was observed between age and practice scores (p = 0.782), whereas age exhibited a significant and positive relationship with attitude scores (p < 0.001). Switching to the practice score results, the median practice score was 3, with an interquartile range of 2 to 3. A considerable 39.6% of participants displayed a good level of practice, representing the highest percentage among students. In the context of attitude score findings, the median attitude score was 4, and the interquartile range was 3 to 4, this suggests that the majority of the participants had a positive attitude towards first aid and its importance. Around 27.6% of participants portrayed a good attitude level, followed by 27% who demonstrated an acceptable attitude level. In addition, gender emerged as a differentiating factor in the three primary outcomes, as females achieved superior results across all aspects. Conclusion: A significant proportion of medical and nursing students at Taibah University have solid FA knowledge, practice, and attitude. Age and education level reflect the impact of FA training and certification, which should be mandatory for all medical students. Further studies are needed to generalize the findings to other contexts.
Isolation and Identification of Pathogens Causing Blue Mold of Lanzhou Lily during Postharvest Storage and Control of Disease and Mycotoxin Accumulation by Ozone Treatment
Authors: Zhang Hui , Xi Jihui , Liu Zhiguang , Chen Minxuan , Lu Zhenhang , Xue Huali , Bi Yang
Published: November 2023

Blue mold (penicilliosis) is a common disease of Lanzhou lily (Lilium davidii var. willmottiae) during postharvest storage, which not only seriously affects the appearance and reduces the quality of lily bulbs, but also leads to the accumulation of mycotoxins in rotten lily tissues, seriously endangering human health. Therefore, it is of great significance to clarify the main isolates causing postharvest blue mold of fresh Lanzhou lily and put forward effective measures to control the disease caused by these pathogens. In this study, pathogens were isolated and purified from the naturally diseased blue-mold tissue of Lanzhou lily, and then morphological and molecular biology techniques were applied to identify the isolates, verify the pathogenicity, determine the disease index and disease incidence, and finally, to analyze the control effect of ozone treatment on the blue mold of lily scale and mycotoxin accumulation. The results indicated that the main isolates causing postharvest blue mold of lily were Talaromyces adpressus, Penicillium gladioli, T. calidominioluteus, and P. polonicum. The pathogenicity test showed that P. gladioli and P. polonicum had a higher disease index than T. calidominioluteus and T. adpressus. Ozone treatment significantly reduced the incidence of disease caused by P. gladioli and P. polonicum, and effectively controlled the accumulation of patulin. This study characterized the main pathogens causing blue mold of postharvest Lanzhou lily during storage, and confirmed ozone application has a significant inhibitory effect on blue mold development and patulin accumulation in Lanzhou lily, which could be helpful in commercially controlling blue mold of postharvest Lanzhou lily during storage.
A Data-Driven Farm Typology as a Basis for Agricultural Land Use Decisions
Authors: Gobin Anne , Van Herzele Ann
Published: November 2023

As a large proportion of land is managed by professional family farms, agent-based models are of interest for simulating agricultural land use. This requires a deep understanding of the farm characteristics that influence land use decisions. We developed a methodology to identify a data-driven farm typology by combining participatory methods, multivariate statistical modeling and spatiotemporal parcel-based land cover analysis between 2000 and 2020. A formal questionnaire provided data on the farm characteristics, which were subjected to principal component analysis and k-means clustering. The resulting data-driven typology complemented a production-based approach to understanding land use decisions. The main influencing factors were farm size, share of private land, dominant crops and participation in European schemes such as NATURA2000 and agri-environment-climate measures. Overall, family tradition and a high return on investment were the most important motivations for maintaining current land use practices, while a higher income, income support and diversification were the most important reasons for pursuing new land use options. Differences between the farm characteristics highlighted the importance of the motivations for land use decisions between the farm types. This methodology can be used to generate data-driven typologies suitable for implementing agent-based models to explore sustainable land management options in a changing environment.
Family Language Policies of Multilingual Families during the COVID-19 Pandemic: Evidence from Cyprus, Estonia, Germany, Israel, and Sweden
Authors: Zabrodskaja Anastassia , Meir Natalia , Karpava Sviatlana , Ringblom Natalia , Ritter Anna
Published: November 2023

This study explored the language and literacy practices of multilingual families in Cyprus, Estonia, Germany, Israel, and Sweden during the COVID-19 pandemic. The study focuses on the different roles of family members in language transmission in order to understand whether these practices might have been influenced by the COVID-19 pandemic. We aimed to answer two key research questions: RQ1, whether and how the pandemic conditions affected the heritage language, societal language acquisition, and heritage language literacy learning environments in the five countries examined (Cyprus, Estonia, Germany, Israel, and Sweden); and RQ2, what is the nature of child and parental agency in facilitation of the possible changes in the corresponding five countries? Fifty semi-structured interviews (ten in each country) were conducted. The data highlighted the factors that triggered changes in family language policy during the pandemic and the role of the child’s agency, parents, extended family, and social network during this period. Based on our findings, we argue that the pandemic conditions gave the children new opportunities for agency when it comes to language and literacy choice and communication with extended family members. This even facilitated new sources of input and suggested the active role of a child as an agent in shaping family language policy in the family.
A Neural Network Architecture for Children’s Audio–Visual Emotion Recognition
Authors: Matveev Anton , Matveev Yuri , Frolova Olga , Nikolaev Aleksandr , Lyakso Elena
Published: November 2023

Detecting and understanding emotions are critical for our daily activities. As emotion recognition (ER) systems develop, we start looking at more difficult cases than just acted adult audio–visual speech. In this work, we investigate the automatic classification of the audio–visual emotional speech of children, which presents several challenges including the lack of publicly available annotated datasets and the low performance of the state-of-the art audio–visual ER systems. In this paper, we present a new corpus of children’s audio–visual emotional speech that we collected. Then, we propose a neural network solution that improves the utilization of the temporal relationships between audio and video modalities in the cross-modal fusion for children’s audio–visual emotion recognition. We select a state-of-the-art neural network architecture as a baseline and present several modifications focused on a deeper learning of the cross-modal temporal relationships using attention. By conducting experiments with our proposed approach and the selected baseline model, we observe a relative improvement in performance by 2%. Finally, we conclude that focusing more on the cross-modal temporal relationships may be beneficial for building ER systems for child–machine communications and environments where qualified professionals work with children.
The Waste Hierarchy at the Business Level: An International Outlook
Authors: Aibar-Guzmán Beatriz , Monteiro Sónia , David Fátima , Somohano-Rodríguez Francisco M.
Published: November 2023

Sustainable waste management is becoming a common goal in most countries. The national legal framework largely determines the waste management practices, the socio-demographic characteristics, and the economic level of the country and, in the case of businesses, the type of business, the industry in which it operates, and the sector-specific regulations to which it is subject. This paper aims to examine the importance that firms worldwide place on waste management by analyzing the evolution over time of waste management practices used by firms and how this evolution has varied across countries and sectors. The X-STATIS technique is applied to conduct a multivariate analysis using data from seven-hundred and eighty firms from twenty-eight countries and eight sectors from 2016 to 2020 (3900 observations). The results show that waste management has become more important worldwide over time. In terms of waste management practices, the management of the impacts of generated waste occupies the first place in the ranking, performed by 97.5% of the sampled firms in 2020; this is followed by the methods of the disposal of non-hazardous waste (66%) while waste prevention policies occupy the last place in the ranking (30.6%). At the country level, the most committed countries are Taiwan (74.3%) and Finland (70.6%), followed by France, Spain, Russia, Italy, and the United States (60.0–66.9%); meanwhile, the least committed countries are the United Kingdom, Australia, and Ireland (35–36%). At the sector level, consumer goods (63.7%) and oil and gas (63.0%) lead the ranking while the least committed sectors are technology and telecommunications (50.0%) and real estate services (49.3%). The evolution of companies’ commitment to waste management is gradual in all sectors, with oil and gas at the top, with a percentage variation of 21.4%, and consumer goods at the bottom, with 5.2%. In addition, our results suggest that the sector influences waste management practices more than the country of origin of the firms.
Pan-Genome Analyses of the Genus Cohnella and Proposal of the Novel Species Cohnella silvisoli sp. nov., Isolated from Forest Soil
Authors: Wang Chunling , Mao Lutian , Bao Gegen , Zhu Honghui
Published: November 2023

Two strains, designated NL03-T5T and NL03-T5-1, were isolated from a soil sample collected from the Nanling National Forests, Guangdong Province, PR China. The two strains were Gram-stain-positive, aerobic, rod-shaped and had lophotrichous flagellation. Strain NL03-T5T could secrete extracellular mucus whereas NL03-T5-1 could not. Phylogenetic analysis based on 16S rRNA gene sequences revealed that the two strains belong to the genus Cohnella, were most closely related to Cohnella lupini LMG 27416T (95.9% and 96.1% similarities), and both showed 94.0% similarity with Cohnella arctica NRRL B-59459T, respectively. The two strains showed 99.8% 16S rRNA gene sequence similarity between them. The draft genome size of strain NL03-T5T was 7.44 Mbp with a DNA G+C content of 49.2 mol%. The average nucleotide identities (ANI) and the digital DNA–DNA hybridization (dDDH) values between NL03-T5T and NL03-T5-1 were 99.98% and 100%, indicating the two strains were of the same species. Additionally, the ANI and dDDH values between NL03-T5T and C. lupini LMG 27416T were 76.1% and 20.4%, respectively. The major cellular fatty acids of strain NL03-T5T included anteiso-C15:0 and iso-C16:0. The major polar lipids and predominant respiratory quinone were diphosphatidylglycerol (DPG) and menaquinone-7 (MK-7). Based on phylogenetic analysis, phenotypic and chemotaxonomic characterization, genomic DNA G+C content, and ANI and dDDH values, strains NL03-T5T and NL03-T5-1 represent novel species in the genus Cohnella, for which the name Cohnella silvisoli is proposed. The type strain is NL03-T5T (=GDMCC 1.2294T = JCM 34999T). Furthermore, comparative genomics revealed that the genus Cohnella had an open pan-genome. The pan-genome of 29 Cohnella strains contained 41,356 gene families, and the number of strain-specific genes ranged from 6 to 1649. The results may explain the good adaptability of the Cohnella strains to different habitats at the genetic level.
Hydrothermal Assembly, Structural Multiplicity, and Catalytic Knoevenagel Condensation Reaction of a Series of Coordination Polymers Based on a Pyridine-Tricarboxylic Acid
Authors: Kang Xiuqi , Ren Chao , Mei Zhenzhong , Fan Xiaoxiang , Xue Jijun , Shao Yongliang , Gu Jinzhong
Published: November 2023

A pyridine-tricarboxylic acid, 5-(3′,5′-dicarboxylphenyl)nicotinic acid (H3dpna), was employed as a adjustable block to assemble a series of coordination polymers under hydrothermal conditions. The seven new coordination polymers were formulated as [Co(μ3-Hdpna)(μ-dpey)]n·nH2O (1), [Zn4.5(μ6-dpna)3(phen)3]n (2), [Co1.5(μ6-dpna)(2,2′-bipy)]n (3), [Zn1.5(μ6-dpna)(2,2′-bipy)]n (4), [Co3(μ3-dpna)2(4,4′-bipy)2(H2O)8]n·2nH2O (5),[Co(bpb)2(H2O)4]n[Co2(μ3-dpna)2(H2O)4]n·3nH2O (6), and [Mn1.5(μ6-dpna)(μ-dpea)]n (7), wherein 1,2-di(4-pyridyl)ethylene (dpey), 1,10-phenanthroline (phen), 2,2′-bipyridine(2,2′-bipy),4,4′-bipyridine(4,4′-bipy),1,4-bis(pyrid-4-yl)benzene (bpb), and 1,2-di(4-pyridyl)ethane (dpea) were employed as auxiliary ligands. The structural variation of polymers 1–7 spans the range from a 2D sheet (1–4, 6, and 7) to a 3D metal–organic framework (MOF, 5). Polymers 1–7 were investigated as heterogeneous catalysts in the Knoevenagel condensation reaction, leading to high condensation product yields (up to 100%) under optimized conditions. Various reaction conditions, substrate scope, and catalyst recycling were also researched. This work broadens the application of H3dpna as a versatile tricarboxylate block for the fabrication of functional coordination polymers.
Selective Stability Indicating Liquid Chromatographic Method Based on Quality by Design Framework and In Silico Toxicity Assessment for Infigratinib and Its Degradation Products
Authors: Ali Awadh M. , Alanazi Mohammed M. , Attwa Mohamed W. , Darwish Hany W.
Published: November 2023

Infigratinib, a protein kinase inhibitor employed in the therapeutic management of cholangiocarcinoma, was subjected to various stress conditions, including hydrolytic (acidic and alkaline), oxidative, photolytic, and thermal stress, in accordance with the rules established by the International Council for Harmonization. A cumulative count of five degradation products was observed. The application of the Quality by Design principle was utilized in the development of a rapid and specific separation method for Infigratinib and its degradation products. The methodology employed in this study was derived from an experimental design approach, which was utilized to examine the critical process parameters associated with chromatographic systems. The reversed-phase high-performance liquid chromatography technique, employing a C18 column and a mobile phase composed of a gradient mixture of 25 mM ammonium acetate buffer at pH 6.0 and acetonitrile, successfully facilitated the chromatographic separation. The methodology was expanded to include the utilization of UPLC-quadrupole tandem mass spectrometry in order to conduct a comprehensive analysis of the structural properties and characterize the degradation products. Overall, five degradation products were found in different stress conditions. The method was verified at certain working points, wherein a linearity range (5.0–200.0 µg/mL) was developed and other parameters such as accuracy, repeatability, selectivity, and system suitability were evaluated. Finally, the toxicity and mutagenicity of Infigratinib and its degradation products were predicted using in silico software, namely DEREK Nexus® (version 6.2.1) and SARAH Nexus® (version 3.2.1). Various toxicity endpoints, including chromosomal damage, were predicted. Additionally, two degradation products were also predicted to be mutagenic.
The Influence of Metal–Support Interactions on the Performance of Ni-MoS2/Al2O3 Catalysts for Dibenzothiophene Hydrodesulfurization
Authors: Yang Chuangchuang , Dai Qiaoling , Hu Anpeng , Yuan Hui , Yang Qinghe
Published: November 2023

In this present work, a new kind of sulfurized hydrodesulfurization catalyst was synthesized via the hydrothermal treatment of MoS2, NiCO3·2Ni(OH)2·4H2O, and Al2O3 precursors, followed by annealing under a H2 atmosphere, which does not require a sulfurization process compared to traditional preparation methods. The influence of the annealing temperature and the type of Al2O3 precursor on the interactions between MoS2 and Al2O3 were studied using X-ray fluorescence spectroscopy, X-ray diffraction, N2 adsorption–desorption, Raman spectroscopy, X-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy. The results indicated an increase in the number of stacked layers of the MoS2 catalyst, accompanied by a decrease in the degree of decoration of Ni atoms onto MoS2 nanoslabs, as a result of the strengthened MoS2–Al2O3 interaction. Subsequently, the efficiency of hydrodesulfurization (HDS) was evaluated using dibenzothiophene as a representative reactant, while establishing a correlation between the structure of the catalyst and its performance. The catalysts, using pseudo-boehmite as the precursor and calcined at 500 °C, synthesized by calcining pseudo-boehmite as the precursor for Al2O3 at a temperature of 500 °C and possessing suitable metal–support interactions, exhibited a reduced number of MoS2 stacking layers and lateral dimensions, along with an optimal decoration degree of Ni atoms, thereby resulting in the highest level of HDS activity.
Insights into the Potential Role of Gordonia alkanivorans Strains in Biotechnologies
Authors: Frantsuzova Ekaterina , Bogun Alexander , Shishkina Lidiya , Vetrova Anna , Solyanikova Inna , Delegan Yanina
Published: November 2023

Members of many species of the genus Gordonia are known for their significant metabolic potential, including the ability to utilize compounds of different structures. The aim of the work was to study the ability of nine G. alkanivorans strains to degrade persistent organic pollutants and to analyze the genomic peculiarities of these strains. The genomes of nine Gordonia alkanivorans strains were sequenced and assembled. The utilization of these strains as alkane and benzoate degraders in environmental biotechnologies, coupled with their capacity to potentially produce diverse secondary metabolites, holds promising prospects for both environmental and pharmaceutical applications.
Indirect Sensing of Subclinical Intramammary Infections in Dairy Herds with a Milking Robot
Authors: Lusis Ivars , Antane Vita , Waldmann Andres
Published: November 2023

This study determined the impact of subclinical intramammary infections (IMIs), such as the major and minor udder pathogens (MaPs and MiPs), on the somatic cell count (SCC) in cow milk and investigated the possibilities of indirect sensing of the udder pathogens using the mastitis detection index (MDi) (DeLaval, Tumba, Sweden). The MDi incorporates quarter-level milk electrical conductivity, blood in milk, and milking interval. The case group (n = 21; MDi ≥ 1.4) was compared with the control group (n = 24; MDi < 1.4) for the presence of IMIs. The microbiological investigation of udder quarter foremilk samples was performed two times with an interval of 10 to 14 days. The case and control groups differed in terms of the occurrence of MaPs and MiPs in milk. During the continuous subclinical IMI and the episodic MaP infection, a higher SCC was detected compared with the episodic MiP infection or quarters without IMI. The novel finding of this study was that by using the milk quality sensor for the sensing of subclinical IMIs, there was an indication for the successful detection of episodic MaPs. However, the sensing of the continuous subclinical IMIs was not possible in the current study and still needs to be investigated.
Carbohydrate-Deficient Transferrin (CDT) as a Biomarker of Alcohol Abuse: A Retrospective Study of the Italian Drinking Trend among Drivers from 2016 to 2022
Authors: Fiorelli Denise , Romani Leonardo , Treglia Michele , Pallocci Margherita , Passalacqua Pierluigi , Coppeta Luca , Marsella Luigi Tonino , Tittarelli Roberta
Published: November 2023

Alcohol abuse is still one of the leading causes of death worldwide. Early diagnosis of alcohol abuse enables preventive intervention on the effects and risks associated with its consumption. Carbohydrate-deficient transferrin (CDT) is one of the most reliable biomarkers of chronic alcohol misuse. We retrospectively studied a population of 12,624 subjects who had their driving license suspended for driving under the influence of alcohol or drugs from 2016 to 2022. The analytical determination of CDT was performed following a certified high-performance liquid chromatography (HPLC) method. Data were split by year, age and gender. The majority of subjects with positive %CDT were male, although the trend of positivity was similar between males and females. A steady increase in both the number of tests performed and the number of positives was observed over the years. Patients aged 41–50 years had the highest prevalence, followed by 51–60, 31–40 and 18–30 years. CDT continues to be a steady marker for diagnosis of alcohol abuse in the majority of cases. Data emerging from our study are in line with the increasing national trends on traffic accidents, injuries and deaths related to alcohol and drug DUI (driving under the influence), requiring the implementation of preventive measures to limit this ever-growing phenomenon.
The Tanaidacea challenge to invasion science: taxonomic ambiguities and small size result in another potential overlooked introduction to the Iberian coast and nearby areas
Authors: Stępień Anna , Jażdżewska Anna M. , Ribeiro Romeu S. , Santos Rafael , Ros Macarena
Published: November 2023

A major challenge in invasion science is detecting overlooked introductions, their pathways of introduction and spread. One of the most successful introduced taxa in aquatic ecosystems are peracarid crustaceans. There are a growing number of reports of accidental introductions of peracarids worldwide, mostly related to human transport hubs (e.g., ports and marinas). Tanaidaceans are especially abundant in these communities. Most frequently given examples of natural and anthropogenic passive dispersers belong to the family Tanaididae. However, their wide distribution requires confirmation. Most records come from 70–80’ of last century, when identification of the species relied only on morphological characters. The small size and large intraspecific variation of tanaidids generate a high taxonomic uncertainty, as in the case of Zeuxo turkensis. Population of this species was previously known from Turkish, Japanese, and Australian coasts. In the two last places this tanaidid was identified as Hexapleomera sasuke, despite there were some premises that it should be synonymized with Z. turkensis. Here we investigate specimens that resembled both Hexapleomera sasuke and Zeuxo turkensis collected in marinas around the Iberian and Moroccan coasts. Integrating morphological and molecular methods (barcoding) we confirmed: (1) the first record and presence of well-structured populations of Z. turkensis in Spain, Portugal and Morocco, representing the first record of the species for Atlantic waters; (2) the conspecificity between H. sasuke and Z. turkensis, which should be synonymized; and (3) the wide distribution of Z. turkensis associated with human transport hubs (i.e. marinas) in the study area, showing its potential for introduction and spread. Integrated approaches and greater taxonomic support are key to advancing knowledge on the origin and invasion patterns of this and other small and poorly known human-mediated widespread species.
Features of the course and treatment of respirator y diseases in senior age
Authors:   FSBEI CPE Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia, Moscow, Korshikova Yu. I.
Published: November 2023

The article presents a generalization of the available information on the course of respiratory diseases in senior age, based on literary data and many years of personal experience of doctor Yuliya Ivanovna Korshikova, PhD Candidate in Medicine, in treating patients by means of herbal medicine.
Films as innovative oral dosage forms (review)
Authors:   Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Noskova V. D. , Sysuev E. B. ,   Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Stepanova E. F. ,   Pyatigorsk Medical and Pharmaceutical Institute — Branch of the Volgograd State Medical University
Published: November 2023

The development of new methods of delivery of biologically active substances is a promising direction. This article discusses the fields of films application, the existing classification, as well as the advantages of the dosage form.
Development of pharmacy information databases
Authors:   FARMCOM, Moscow, Agafonov A. A. , Rashchupkina L. V. ,   College of Economics, Insurance and Information Technologies CEII, Moscow, Margaryan A. G. ,   I. M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Polikarpov E. V. ,   I. M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Sologova S. S. ,   I. M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Smolyarchuk Е. А. ,   I. M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow
Published: November 2023

In the work, the task of creating a pharmacy database was set, and a study of this subject area was conducted. The development of the information database was implemented by means of the Master’s program in order to improve the efficiency of its work. This development can be used in small pharmacies and large pharmacy chains, as well as in pharmaceutical companies involved in the production and pharmacy automation.
Les éleveurs face aux risques épizootiques répétés. Le cas exemplaire des éleveurs de brebis laitières du Pays basque confrontés à l’agalactie contagieuse
Authors: Nicourt Christian , Cabaret Jacques
Published: November 2023

Le Pays basque est particulièrement frappé par différentes épizooties qui affectent les élevages ovins. La configuration de ces élevages, c’est à dire leur petite taille, leur grande densité dans la région, leurs différentes manières d’élever les animaux se distinguent des normes habituelles d’élevage des brebis en France et semble contribuer à cette expression des maladies. L’alimentation des animaux ne provient pas majoritairement des exploitations, mais de pâtures collectives aux coûts de location modiques, gérées par des collectivités territoriales. Dans ce contexte, les épizooties mettent les éleveurs à l’épreuve, en leur imposant des contraintes drastiques, qui ne leur permettent plus d’utiliser ces pâtures. Qu’en est-il alors de leurs manières de travailler et d’être ensemble sous cette contrainte ? En prenant le cas d’une de ces épizooties particulièrement présente au Pays basque - l’agalactie contagieuse - après avoir examiné les manières singulières de travailler de ces éleveurs, nous analyserons comment ils sont vulnérabilisés par la survenue de l’agalactie contagieuse et enfin comment sa gestion publique est source de tensions. Mots-clés : élevage ovin, épizooties, agalactie, estives, tensions sociales, Pays basque
Enjeux biotechnologiques (nouvelles techniques génomiques) : vers une évolution de la réglementation européenne ?
Authors: Regnault-Roger Catherine
Published: November 2023

La réglementation appliquée aux nouvelles techniques génomiques d’édition du génome (dont CRISPR), constitue un point-clef pour définir quelle place chaque pays leur accorde pour développer des solutions innovantes en santé humaine, en santé et bien-être animal, ainsi qu’en santé végétale et pour faire face aux changements climatiques. Devant ces immenses perspectives et en raison des risques mieux maîtrisés par les techniques d’édition du génome, de très nombreux pays (USA, Japon, Argentine, Brésil, Australie etc.) ont décidé de restreindre voire d’abandonner dans certains cas la réglementation appliquée à la majorité des produits d’édition du génome au contraire de l’Union européenne (UE) qui se retrouve isolée après l’arrêt de la Cour de Justice (CJUE) de 2018. Ce contexte a donné lieu à des débats tant politiques qu’académiques et la Commission européenne a lancé une initiative stratégique pour faire évoluer la réglementation appliquée à certains produits d’édition vis-à-vis des végétaux. Quels en sont les termes ? Sont donnés ici quelques éléments de compréhension des enjeux liés à cette question. Mots clés : Nouvelles techniques génomiques, Réglementation, Cour Justice européenne (CJUE), Initiative européenne pour des applications végétales
Séance thématique : "animaux à génome édité : science, réglementation et société"
Authors: Montagutelli Xavier
Published: November 2023

Edition génomique, animaux de rente, réglementation, perception sociétale
Optimizing Holt-Winters Exponential Smoothing Parameters for Construction Cost Index Forecasting with PSO and Walk-Forward Cross-Validation
Authors: TÜZ EBESEK Özlem , EBESEK Şafak
Published: November 2023

This research aims to enhance the accuracy of Construction Cost Index (CCI) forecasting using Holt-Winters exponential smoothing (ES) by optimizing its parameters, focusing on minimizing the Mean Absolute Percentage Error (MAPE) for precise CCI forecasts. To reach this aim, The Holt-Winters model parameters are optimized through Particle Swarm Optimization (PSO) and Walk-Forward Cross-Validation (WFCV). PSO, a metaheuristic optimization algorithm, is being applied to search for optimal values of the smoothing parameters (alpha, beta, and gamma) that determine the weightage of past observations, trends, and seasonality, respectively. WFCV is assessed the model's performance and ensures robustness. Reduced MAPEs of 22 for CCI forecasts and 2 for training data are the findings of the optimized Holt-Winters model. The obtained alpha, beta, and gamma values are 0.99, 0.77, and 0, respectively, highlighting the importance of while neglecting seasonality. Convergence graphs demonstrate the superiority of the optimization approach over conventional parameter values or random selections. By employing PSO and WFCV, the study efficiently fine-tunes the Holt-Winters model for precise CCI forecasting. Optimized parameter values enable data driven decision-making in construction project cost estimation and budget management. This research contributes a reliable and robust optimization methodology for CCI forecasting, supporting advancements in the field.