bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiomic profiling for insular diffuse glioma stratification with distinct biologic pathway activities
Authors: Duan Wenchao , Wang Zilong , Ma Zeyu , Zheng Hongwei , Li Yinhua , Pei Dongling , Wang Minkai , Qiu Yuning , Duan Mengjiao , Yan Dongming , Ji Yuchen , Cheng Jingliang , Liu Xianzhi , Zhang Zhenyu , Yan Jing
Published: January 2024

Current literature emphasizes surgical complexities and customized resection for managing insular gliomas; however, radiogenomic investigations into prognostic radiomic traits remain limited. We aimed to develop and validate a radiomic model using multiparametric magnetic resonance imaging (MRI) for prognostic prediction and to reveal the underlying biological mechanisms. Radiomic features from preoperative MRI were utilized to develop and validate a radiomic risk signature (RRS) for insular gliomas, validated through paired MRI and RNA‐seq data (N = 39), to identify core pathways underlying the RRS and individual prognostic radiomic features. An 18‐feature‐based RRS was established for overall survival (OS) prediction. Gene set enrichment analysis (GSEA) and weighted gene coexpression network analysis (WGCNA) were used to identify intersectional pathways. In total, 364 patients with insular gliomas (training set, N = 295; validation set, N = 69) were enrolled. RRS was significantly associated with insular glioma OS (log‐rank p = 0.00058; HR = 3.595, 95% CI:1.636–7.898) in the validation set. The radiomic‐pathological‐clinical model (R‐P‐CM) displayed enhanced reliability and accuracy in prognostic prediction. The radiogenomic analysis revealed 322 intersectional pathways through GSEA and WGCNA fusion; 13 prognostic radiomic features were significantly correlated with these intersectional pathways. The RRS demonstrated independent predictive value for insular glioma prognosis compared with established clinical and pathological profiles. The biological basis for prognostic radiomic indicators includes immune, proliferative, migratory, metabolic, and cellular biological function‐related pathways.
An emotion‐focused extension of coercion theory: Emerging evidence and conceptualizations for parental experienced emotion as a mechanism of reinforcement in coercive parent–child interactions
Authors: Moed Anat
Published: January 2024

According to coercion theory (Patterson, 1982, 2016), children's aggression is developed and maintained through transactional processes between parents and their children that unfold over time. The theory provides a model of the behavioral contingencies that explain how parents and children mutually “train” each other to behave in ways that over time increase the likelihood of children's aggression and decrease parents' control over this aggression. Although the theory characterizes the interactions that often lead to dysfunctional family processes and children's aggression, its focus on observable, interpersonal negativity has resulted in research that largely overlooks intraindividual phenomena, such as the internal experiences that drive parents' expressed negativity. In this article, I present empirical and theoretical work that supports an expanded focus of coercion theory to include emotion as an internal mechanism of reinforcement that facilitates and maintains coercive family processes and children's antisocial development.
Hand Gestures Have Predictive Potential During Conversation: An Investigation of the Timing of Gestures in Relation to Speech
Authors: ter Bekke Marlijn , Drijvers Linda , Holler Judith
Published: January 2024

During face‐to‐face conversation, transitions between speaker turns are incredibly fast. These fast turn exchanges seem to involve next speakers predicting upcoming semantic information, such that next turn planning can begin before a current turn is complete. Given that face‐to‐face conversation also involves the use of communicative bodily signals, an important question is how bodily signals such as co‐speech hand gestures play into these processes of prediction and fast responding. In this corpus study, we found that hand gestures that depict or refer to semantic information started before the corresponding information in speech, which held both for the onset of the gesture as a whole, as well as the onset of the stroke (the most meaningful part of the gesture). This early timing potentially allows listeners to use the gestural information to predict the corresponding semantic information to be conveyed in speech. Moreover, we provided further evidence that questions with gestures got faster responses than questions without gestures. However, we found no evidence for the idea that how much a gesture precedes its lexical affiliate (i.e., its predictive potential) relates to how fast responses were given. The findings presented here highlight the importance of the temporal relation between speech and gesture and help to illuminate the potential mechanisms underpinning multimodal language processing during face‐to‐face conversation.
Valorisation of Napier grass through fibre extraction and coloration by natural dye from Rubia tinctorum
Authors: Patil Harshal , Yadav Suraj , Athalye Ashok
Published: January 2024

Agricultural biomass is a well‐known renewable resource with a strong possibility of recycling. The current work focuses on extracting, preparing and colouring Napier grass fibre (NGF) with a colourant extracted from Rubia tinctorum (RT) (which is generally known as madder). NGF that had been water‐retted was alkaline scoured and bleached using hydrogen peroxide to increase the material's whiteness index and water absorption capacity without degrading its breaking strength. After being mordanted with tannic acid, the bleached NGF was coloured with an aqueous extract of the colourant extracted from RT. The Box–Behnken response surface methodology design model was employed to optimise the dyeing concentration, temperature and time. The dyed fibre showed good colour strength (K/S) and adequate wash, rub and light fastness. Adopting the findings from the current study would increase the efficient utilisation of biomass for use in textiles, which is unnecessarily wasted.
Real‐world implementation of DPYD and UGT1A1 pharmacogenetic testing in a community‐based cancer center
Authors: Muldoon Megan , Beck Mollie , Sebree Nichlas , Yoder Robin , Ritter Stacey , Allen Josiah D. , Alqahtani Zuhair , Grund Jaime , Philips Brooke , Hesse Kristina , El Rouby Nihal
Published: January 2024

We set out to demonstrate the feasibility of pharmacogenetic testing of DPYD and UGT1A1 and explore the clinical benefits in a community‐based cancer center. We conducted a retrospective review of 280 patients who underwent pharmacogenetic testing between November 2020 and May 2023. The primary end points included the percentage of patients with results prior to chemotherapy initiation, percentage of DPYD‐ and UGT1A1‐guided interventions implemented before chemotherapy initiation, and the turnaround time (TAT) for the pharmacogenetics results. Exploratory end points included a comparison of unplanned hospitalizations and treatment interruptions among (1) DPD phenotypes in patients who received fluoropyrimidines and (2) UGT1A1 phenotypes in patients who received irinotecan ± fluoropyrimidines. We evaluated cancer progression among patients who received DPYD‐guided dose reductions in the curative setting. More than 75% of patients had results prior to initiation of chemotherapy and 61.5% of the actionable interventions were implemented before chemotherapy, with a median TAT of 7 calendar days (IQR 5–8 calendar days). A non‐significant higher percentage of unplanned hospitalizations and treatment interruptions occurred among patients with normal DPYD compared with patients with DPYD‐guided dose reductions. A non‐significant higher frequency of treatment interruptions and dose reductions were observed in UGT1A1 intermediate metabolizer (IM) compared with UGT1A1 normal metabolizer (NM). None of the patients who received DPYD‐guided dose reductions in the curative setting experienced progression after a median follow‐up of 342 days. The real‐world evidence generated from this study demonstrates the feasibility of pre‐chemotherapy pharmacogenetic testing of DPYD and UGT1A1 in a community‐based cancer center.
Quantification of increased biologically active CXCL12α plasma concentrations after ACKR3 antagonist treatment in humans
Authors: Blattmann Peter , Farine Hervé , Dan Brian , Stiffler Nicole , Lefebvre Thomas , Huynh Christine , Sidharta Patricia N. , Dingemanse Jasper , Welford Richard W. D. , Keller Marcel , Strasser Daniel S.
Published: January 2024

CXCL12 acts as a chemoattractant by binding to the receptor CXCR4. The (atypical) chemokine receptor ACKR3 (CXCR7) scavenges CXCL12. Antagonism of ACKR3 thus leads to an increase in CXCL12 concentrations that has been used as a pharmacodynamic biomarker in healthy adults. Increased CXCL12 concentrations have also been linked to repair mechanisms in human diseases and mouse models. To date, CXCL12 concentrations have typically been quantified using antibody‐based assays with overlapping or unclear specificity for the various CXCL12 isoforms (α, β, and γ) and proteoforms. Only the N‐terminal full‐length CXCL12 proteoform is biologically active and can engage CXCR4 and ACKR3, but this proteoform could so far not be quantified in healthy adults. Here, we describe a new and fit‐for‐purpose validated immunoaffinity mass spectrometry (IA‐MS) assay for specific measurement of five CXCL12α proteoforms in human plasma, including the biologically active CXCL12α proteoform. This biomarker assay was used in a phase I clinical study with the ACKR3 antagonist ACT‐1004‐1239. In placebo‐treated healthy adults, 1.0 nM total CXCL12α and 0.1 nM biologically active CXCL12α was quantified. The concentrations of both proteoforms increased up to two‐fold in healthy adults compared to placebo following drug administration. At all dose levels, 10% of the CXCL12α was the biologically active proteoform and the simultaneous increase of all proteoforms suggests that a new steady state has been reached 24 h following dosing. Hence, this IA‐MS biomarker assay can be used to specifically measure active CXCL12 proteoform concentrations in clinical trials to demonstrate target engagement and correlate with clinical outcomes.
Solid pseudopapillary neoplasm of pancreas with liver metastasis, diagnosed on fine needle aspiration cytology (FNAC)
Authors: Ahsan Beena U. , Khan Mahmood , Zhang Ziying
Published: January 2024

Solid pseudopapillary neoplasm of the pancreas is a rare tumour with distinct clinicopathological features. The tumour most commonly occurs in younger women and has low malignant potential with an excellent overall prognosis.
Temperature seasonality drives taxonomic and functional homogenization of tropical butterflies
Authors: Hulshof Catherine M. , Ackerman James D. , Franqui Rosa A. , Kawahara Akito Y. , Restrepo Carla
Published: January 2024

Aim

To better understand the potential impact of climate change on butterfly assemblages across a tropical island, we model the potential for taxonomic and functional homogenization and determine climate‐ and trait‐mediated shifts in projected species distributions.

Location

Puerto Rico.

Methods

We used thousands of museum records of diurnal Lepidoptera to model current (1970–2000) and forecast future (2061–2080) species distributions and combined these to test for taxonomic and functional homogenization. We then quantified climatic‐mediated effects on current and forecasted taxonomic and functional composition and, specifically, whether temperature was a primary driver, as predicted by the temperature–size rule and the thermal melanism hypotheses. Finally, we measured wing traits important in thermoregulation (size and colour) and determined trait‐mediated changes in forecasted species distributions over time.

Results

Based on ensemble model outputs, taxonomic and functional richness and turnover were predicted to vary across the island's complex topography. Our models projected an increase in taxonomic and functional richness over time, and a decrease in taxonomic and functional turnover – a signature of biotic homogenization. Under future climate scenarios, models projected a decrease in wing length and an increase in wing brightness at higher elevations. One variable, temperature seasonality, was the strongest predicted driver of both the current spatial distribution and the projected per cent change over time for not only wing traits but also taxonomic and functional richness and turnover.

Main conclusions

The species distribution models generated here identify several priority regions and species for future research and conservation efforts. Our work also highlights the role of seasonality and climatic variability on diverse tropical Lepidoptera assemblages, suggesting that climatic variability may be an important, albeit overlooked, driver of climate change responses.
Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons
Authors: Aabdien Afra , Sichlinger Laura , Borgel Zoe , Jones Madeleine R. , Waston Iain A. , Gatford Nicholas J. F. , Raval Pooja , Tanangonan Lloyd , Powell Timothy R. , Duarte Rodrigo R. R. , Srivastava Deepak P.
Published: January 2024

The zinc finger protein 804A (ZNF804A) and the 5′‐nucleotidase cytosolic II (NT5C2) genes are amongst the first schizophrenia susceptibility genes to have been identified in large‐scale genome‐wide association studies. ZNF804A has been implicated in the regulation of neuronal morphology and is required for activity‐dependent changes to dendritic spines. Conversely, NT5C2 has been shown to regulate 5′ adenosine monophosphate‐activated protein kinase activity and has been implicated in protein synthesis in human neural progenitor cells. Schizophrenia risk genotype is associated with reduced levels of both NT5C2 and ZNF804A in the developing brain, and a yeast two‐hybrid screening suggests that their encoded proteins physically interact. However, it remains unknown whether this interaction also occurs in cortical neurons and whether they could jointly regulate neuronal function. Here, we show that ZNF804A and NT5C2 colocalise and interact in HEK293T cells and that their rodent homologues, ZFP804A and NT5C2, colocalise and form a protein complex in cortical neurons. Knockdown of the Zfp804a or Nt5c2 genes resulted in a redistribution of both proteins, suggesting that both proteins influence the subcellular targeting of each other. The identified interaction between ZNF804A/ZFP804A and NT5C2 suggests a shared biological pathway pertinent to schizophrenia susceptibility within a neuronal cell type thought to be central to the neurobiology of the disorder, providing a better understanding of its genetic landscape.
Focal electroclinical features in generalized tonic–clonic seizures: Decision flowchart for a diagnostic challenge
Authors: Vlachou Maria , Ryvlin Philippe , Armand Larsen Sidsel , Beniczky Sándor
Published: January 2024

Objective

Bilateral tonic–clonic seizures with focal semiology or focal interictal electroencephalography (EEG) can occur in both focal and generalized epilepsy types, leading to diagnostic errors and inappropriate therapy. We investigated the prevalence and prognostic values of focal features in patients with idiopathic generalized epilepsy (IGE), and we propose a decision flowchart to distinguish between focal and generalized epilepsy in patients with bilateral tonic–clonic seizures and focal EEG or semiology.

Methods

We retrospectively analyzed video‐EEG recordings of 101 bilateral tonic–clonic seizures from 60 patients (18 with IGE, 42 with focal epilepsy). Diagnosis and therapeutic response were extracted after ≥1‐year follow‐up. The decision flowchart was based on previous observations and assessed concordance between interictal and ictal EEG.

Results

Focal semiology in IGE was observed in 75% of seizures and 77.8% of patients, most often corresponding to forced head version (66.7%). In patients with multiple seizures, direction of head version was consistent across seizures. Focal interictal epileptiform discharges (IEDs) were observed in 61.1% of patients with IGE, whereas focal ictal EEG onset only occurred in 13% of seizures and 16.7% of patients. However, later during the seizures, a reproducible pattern of 7‐Hz lateralized ictal rhythm was observed in 56% of seizures, associated with contralateral head version. We did not find correlation between presence of focal features and therapeutic response in IGE patients. Our decision flowchart distinguished between focal and generalized epilepsy in patients with bilateral tonic–clonic seizures and focal features with an accuracy of 96.6%.

Significance

Focal semiology associated with bilateral tonic–clonic seizures and focal IEDs are common features in patients with IGE, but focal ictal EEG onset is rare. None of these focal findings appears to influence therapeutic response. By assessing the concordance between interictal and ictal EEG findings, one can accurately distinguish between focal and generalized epilepsies.
A lack of genetic diversity and minimal adaptive evolutionary divergence in introduced Mysis shrimp after 50 years
Authors: Cheek Rebecca G. , McLaughlin Jessica F. , Gamboa Maybellene P. , Marshall Craig A. , Johnson Brett M. , Silver Douglas B. , Mauro Alexander A. , Ghalambor Cameron K.
Published: January 2024

The successes of introduced populations in novel habitats often provide powerful examples of evolution and adaptation. In the 1950s, opossum shrimp (Mysis diluviana) individuals from Clearwater Lake in Minnesota, USA were transported and introduced to Twin Lakes in Colorado, USA by fisheries managers to supplement food sources for trout. Mysis were subsequently introduced from Twin Lakes into numerous lakes throughout Colorado. Because managers kept detailed records of the timing of the introductions, we had the opportunity to test for evolutionary divergence within a known time interval. Here, we used reduced representation genomic data to investigate patterns of genetic diversity, test for genetic divergence between populations, and for evidence of adaptive evolution within the introduced populations in Colorado. We found very low levels of genetic diversity across all populations, with evidence for some genetic divergence between the Minnesota source population and the introduced populations in Colorado. There was little differentiation among the Colorado populations, consistent with the known provenance of a single founding population, with the exception of the population from Gross Reservoir, Colorado. Demographic modeling suggests that at least one undocumented introduction from an unknown source population hybridized with the population in Gross Reservoir. Despite the overall low genetic diversity we observed, FST outlier and environmental association analyses identified multiple loci exhibiting signatures of selection and adaptive variation related to elevation and lake depth. The success of introduced species is thought to be limited by genetic variation, but our results imply that populations with limited genetic variation can become established in a wide range of novel environments. From an applied perspective, the observed patterns of divergence between populations suggest that genetic analysis can be a useful forensic tool to determine likely sources of invasive species.
Inclusion and anti‐racism work as performance or deep work? It literally is either‐or: A qualitative study in the CFT field
Authors: Rajaei Afarin , Lattenhauer Tyler
Published: January 2024

This study explores the experience of promoting inclusion and anti‐racism work as either performance or deep work in the couple and family therapy (CFT) field through narrative qualitative analysis. While performance‐based approaches focus on meeting external expectations and diversity quotas, deep work involves critical self‐reflection, ongoing learning, and a commitment to addressing systemic inequalities. The paper prioritizes how deep inclusion assists with developing new approaches to creating meaningful and lasting change in teaching, research, and clinical work in the CFT field. Some professionals in the field include educators, researchers, and therapists who are engaged in anti‐racism work, a recognition of the impact of systemic racism on family dynamics and therapeutic interventions, and a commitment to centering the voices and experiences of marginalized individuals and communities. Implications present a need for ongoing education, training, and support for professionals in the CFT field and other family science and family mental health‐related professions. This study also identifies limitations and future directions for research in promoting inclusion and anti‐racism work in family science and family mental health‐related fields. It is essential to promote inclusion and anti‐racism as deep work to create more inclusive and equitable teaching, research, and therapeutic environments that value the experiences of all individuals and communities. Challenges include resistance from shaking systems and making ourselves and others vulnerable with uncomfortable and continuous conversations. Our primary goal is to contribute to and inspire dialogue about the perspectives CFTs and other mental health‐related professionals are taking in the relationship to inclusion and anti‐racism work.
Effect of spermidine on long non‐coding RNAs MALAT1 in a rotenone induced‐rat model of Parkinson's disease
Authors: Badae Noha Mohamed , Abdelmonsif Doaa A. , Aly Rania Gaber , Omar Amira M. , Shoela Mai S. , Omar Eman M.
Published: January 2024

Background

Spermidine is a natural biologically active substance that has widespread influences on the body.

Objective

This study aims to enhance our understanding of the potential effect of spermidine on long non‐coding RNA MALAT1 and explore the underlying mechanism in the rotenone‐induced rat model of Parkinson's disease.

Methods

Rats were sacrificed after locomotor behavioral testing. Striatal tissues were used to assess the expression of MALAT1, oxidative stress markers, and autophagy markers.

Results

Our study found that treatment with spermidine for 2 weeks during the induction of the model significantly improved behavioral assessment, dopamine levels, and attenuated the histopathological changes that occurred in PD in comparison to the non‐treated group.

Conclusion

Our preliminary study supports the protective effect of spermidine on the activation of autophagy and its antioxidant properties. Part of the antioxidant activity is due to the inhibition of MALAT1. However, MALAT1 does not correlate with the spermidine‐induced autophagy pathway.
Role of biomarkers and molecular signaling pathways in acute lung injury
Authors: Niri Pakter , Saha Achintya , Polopalli Subramanyam , Kumar Mohit , Das Sanghita , Chattopadhyay Pronobesh
Published: January 2024

Background

Acute lung injury (ALI) is caused by bacterial, fungal, and viral infections. When pathogens invade the lungs, the immune system responds by producing cytokines, chemokines, and interferons to promote the infiltration of phagocytic cells, which are essential for pathogen clearance. Their excess production causes an overactive immune response and a pathological hyper‐inflammatory state, which leads to ALI. Until now, there is no particular pharmaceutical treatment available for ALI despite known inflammatory mediators like neutrophil extracellular traps (NETs) and reactive oxygen species (ROS).

Objectives

Therefore, the primary objective of this review is to provide the clear overview on the mechanisms controlling NETs, ROS formation, and other relevant processes during the pathogenesis of ALI. In addition, we have discussed the significance of epithelial and endothelial damage indicators and several molecular signaling pathways associated with ALI.

Methods

The literature review was done from Web of Science, Scopus, PubMed, and Google Scholar for ALI, NETs, ROS, inflammation, biomarkers, Toll‐ and nucleotide‐binding oligomerization domain (NOD)‐like receptors, alveolar damage, pro‐inflammatory cytokines, and epithelial/endothelial damage alone or in combination.

Results

This review summarized the main clinical signs of ALI, including the regulation and distinct function of epithelial and endothelial biomarkers, NETs, ROS, and pattern recognition receptors (PRRs).

Conclusion

However, no particular drugs including vaccine for ALI has been established. Furthermore, there is a lack of validated diagnostic tools and a poor predictive rationality of current therapeutic biomarkers. Hence, extensive and precise research is required to speed up the process of drug testing and development by the application of artificial intelligence technologies, structure‐based drug design, in‐silico approaches, and drug repurposing.
Influence of constitutive equation and friction on measurement of creep strain rate based on small specimen testing technique
Authors: Tan Jianping , Chang Shuai , Zhang Kun , Li Sikuan , Chen Shijian , Fu Jia
Published: January 2024

Two stress regime‐dependent creep constitutive equations, that is, two‐regime Norton (2RN) model and Sin‐hyperbolic (Sinh) model, are adopted to numerically investigate the influence of constitutive equation and friction on the measurement of steady‐state creep strain rate based on five types small specimens. Results show that the influence of constitutive equation and friction depends strongly on the type of small specimen. A measurement error of more than 19 times may occur if the 2RN model is used, while the use of the Sinh model is able to generate a consistently lower measurement error. Of all small specimens, the cantilever beam testing (CaBT) is revealed to exhibit the best comprehensive performance in terms of measurement error and response to friction. To validate numerical findings, creep tests on the CaBT specimen of P91 steel are conducted at 600°C. Finally, recommendations on the choice of small specimen for obtaining creep strain rate are made.
Populist government support and frontline workers' self‐efficacy during crisis
Authors: Lotta Gabriela , Thomann Eva , Fernandez Michelle , Vogler Jan , Leandro Arthur , Corrêa Marcela Garcia
Published: January 2024

Frontline workers who are confronted with crises need enormous resilience and the ability to deal with stress from crisis‐related increases in demands and risks. Simultaneously, populist governments with an illiberal agenda may undermine the work of street‐level bureaucracies for political reasons. Little is known about how deconstruction of the administrative state by populist government—through lacking government support when it is needed the most—affects frontline work. Thus, this article asks: how does lacking support by a populist government affect frontline workers' self‐efficacy when they face a crisis? Based on unique data from an online survey of 3229 Brazilian frontline workers during the early COVID‐19 pandemic, when the Bolsonaro government denied the existence of the pandemic, we test the relationship between government support, demands, and resources on frontline workers' perceived self‐efficacy. Results show that lacking government support from the federal and local government are negatively associated with frontline workers' self‐efficacy. At the same time, resources and managerial support exhibit positive associations—but they cannot always compensate for a lack of government assistance.
Board characteristics and sustainability in higher education institutions: The case of the United Kingdom
Authors: Aly Doaa , Abdelqader Muath , Darwish Tamer K. , Toporkiewicz Anna , Radwan Ali
Published: January 2024

We explored the relationship between board characteristics and sustainability of higher education institutions in the United Kingdom (UK). We analysed 153 UK universities using data for the year 2019. Our analysis revealed that board size, the number of students on the board, and the number of academic members on the board were found to have significant and positive relationships with sustainability. Also, the composition of the sustainability committee was shown to have a significant and positive impact on sustainability score. However, the relationships between board gender diversity, the number of external members on the board, and the number of board meetings held during the year with sustainability score were not significant. The results provide guidance to universities for developing their sustainability practices.
The League: A person‐centred approach to the development of social robotics for paediatric anxiety
Authors: Dosso Jill A. , Kailley Jaya N. , Robillard Julie M.
Published: January 2024

Background

Social robots are promising tools to improve the quality of life of children and youth living with anxiety and should be developed based on the priorities of end users. However, pathways to include young people in patient‐oriented research, particularly in the overlap between technology and mental health, have been historically limited.

Objective

In this work, we describe engagement with experts with lived experiences of paediatric anxiety in a social robotics research programme. We report the experiences of patient advisors in a co‐creation process and identify considerations for other research groups looking to involve end users in technology development in the field of youth mental health.

Design

We engaged individuals with a lived experience of paediatric anxiety (current, recent past, or from a parent perspective) using three different models over the course of three years. Two initial patient partners were involved during project development, eight were engaged as part of an advisory panel (‘the League’) during study development and data analysis and four contributed as ongoing collaborators in an advisory role. League members completed a preparticipation expectation survey and a postparticipation experience survey.

Findings

Eight individuals from a range of anxiety‐related diagnostic groups participated in the League as patient partners. Members were teenagers (n = 3), young adults aged 22–26 years who had connected with a youth mental health service as children within the past eight years (n = 3) or parents of children presently living with anxiety (n = 2). Preferred methods of communication, expectations and reasons for participating were collected. The League provided specific and actionable feedback on the design of workshops on the topic of social robotics, which was implemented. They reported that their experiences were positive and fairly compensated, but communication and sustained engagement over time were challenges. Issues of ethics and language related to patient‐centred brain health technology research are discussed.

Conclusions

There is an ethical imperative to meaningfully incorporate the voices of youth and young adults with psychiatric conditions in the development of devices intended to support their mental health and quality of life.

Patient or Public Contribution

Six young people and two parents with lived experiences of paediatric anxiety participated in all stages of developing a research programme on social robotics to support paediatric mental health in a community context. They also provided input during the preparation of this manuscript.
Osteopontin interacts with dendritic cells and macrophages in pulp inflammation: Comprehensive transcriptomic analysis and laboratory investigations
Authors: Chen Leyi , Zhu Mingqi , Zhang Chuhan , Wang Ziting , Lyu Xiaolin , Xu Wenan , Wu Buling
Published: January 2024

Aim

To investigate novel diagnostic markers for pulpitis and validate by clinical samples from normal and inflamed pulp. To explore the relationship between diagnostic markers and immune cells or their phenotypes during pulp inflammation.

Methodology

Two microarray datasets, GSE77459 and GSE92681, and identified differential expression genes were integrated. To understand immune features, gene functions, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Disease Ontology (DO) and ImmuneSigDB Gene Set Enrichment Analysis (GSEA) were analysed. For predictive purposes, machine learning techniques were applied to detect diagnostic markers. Immune infiltration in inflamed pulp was studied using CIBERSORT. The relationship between diagnostic markers and immune cells was investigated and validated their gene expression in clinical samples from the normal or inflamed pulp by qRT‐PCR. Finally, the correlation between one marker, secreted phosphoprotein 1 (SPP1), encoding osteopontin (OPN), and dendritic cells (DCs)/macrophages was identified via HE staining and multiplex immunohistochemistry. An in vitro inflammatory dental pulp microenvironment model of THP‐1 macrophages cocultured with dental pulp cells derived conditioned media (DPCs‐CM) to investigate OPN production and macrophage phenotypes was established.

Results

Analysis revealed unique immunologic features in inflamed pulp. Three diagnostic markers for pulpitis: endothelin‐1 (EDN1), SPP1, and purine nucleoside phosphorylase (PNP), and validated them using qRT‐PCR were predicted. Multiplex immunohistochemistry demonstrated OPN co‐localized with activated DCs and M2 macrophages during pulp inflammation. In vitro experiments showed that THP‐1 macrophages produced the highest levels of OPN when stimulated with DPCs‐CM derived from the 20 μg/mL LPS pre‐conditioned group, suggesting an M2b‐like phenotype by increasing surface marker CD86 and expression of IL6, TNFα, IL10, and CCL1 but not CCL17 and MerTK. Levels of CCL1 and IL10 elevated significantly in the macrophages' supernatant from the 20 μg/mL LPS pre‐conditioned CM group. OPN was proven co‐localizing with CD86 in the inflamed pulp by immunofluorescence.

Conclusions

The current findings suggest that OPN can serve as a promising biomarker for pulpitis, correlated with DCs and macrophages. OPN+ macrophages in the inflamed pulp are associated with M2b‐like phenotypes. These insights offer the potential for improved diagnosis and targeted therapy.
Effect of preemptive use of a nonsteroidal anti‐inflammatory drug and a corticosteroid on the efficacy of inferior alveolar nerve blockade and postoperative pain control in endodontic treatment of molars with symptomatic pulpitis: A randomized double‐blind placebo‐controlled clinical trial
Authors: Rodrigues Guilherme Araujo , Hizatugu Ruy , Bronzato Juliana Delatorre , de‐Jesus‐Soares Adriana , Frozoni Marcos
Published: January 2024

Aim

The anaesthetic success rate of an inferior alveolar nerve block (IANB) in mandibular molars with irreversible symptomatic pulpitis can be low, and postoperative pain control in teeth with this diagnosis can be challenging. This study aimed to evaluate the influence of preemptive use of dexamethasone and oral potassium diclofenac on the success of IANB. The influence of these drugs on the intensity of postoperative pain was assessed as a secondary outcome.

Methodology

Eighty‐four patients with mandibular molars diagnosed with irreversible symptomatic pulpitis recorded preoperative pain intensity using a cold thermal test and a modified Numerical Rating Scale (mNRS). Sixty minutes before the anaesthetic procedure, patients were randomly assigned to one of three groups based on the medication they received: dexamethasone (4 mg), diclofenac potassium (50 mg), or placebo. All patients received IANB with 4% articaine (1:200 000 epinephrine), and 15 min later, they were evaluated for pain intensity using the cold thermal test. Anaesthetic success was analysed. The pain intensity was then recorded, and endodontic treatment and provisional restoration of the tooth were executed in a single session. Patients were monitored for 6, 12, 24, 48 and 72 h using the mNRS to assess the intensity of postoperative pain.

Results

There was a statistically significant increase in anaesthetic success when 4 mg dexamethasone (39.3%) or 50 mg diclofenac potassium (21.4%) was used compared to the placebo group (3.6%) (p < .001), with no significant difference between the two drugs. Regarding postoperative pain, dexamethasone was superior to placebo at 6 h (p < .001), with diclofenac having an intermediate behaviour, not differing between dexamethasone and placebo (p > .05). There was no significant difference amongst the groups at 12 h (p > .05). At 24, 48 and 72 h, the effectiveness of dexamethasone and diclofenac were comparable, and both were superior to placebo (p < .001).

Conclusion

The use of dexamethasone or diclofenac potassium was favourable in terms of increasing the success rate of inferior alveolar nerve block in cases of mandibular molars with irreversible symptomatic pulpitis and decreased the occurrence of postoperative pain when compared to the use of a placebo.
What is (and is not) stakeholder dialogue in CSR? A review and research agenda
Authors: Acuti Diletta , Glozer Sarah , Crane Andrew
Published: January 2024

Stakeholders increasingly expect to be engaged in corporate social responsibility (CSR) agendas through dialogue; the joint creation of meaning between firms and stakeholders, or among stakeholders. Dominant conceptions of stakeholder dialogue in CSR prioritize firm interests, and uncertainty as to what constitutes stakeholder dialogue, and how it should be practiced, permeates theory and practice. What is (and is not) stakeholder dialogue and how does it generate positive impacts for business and society? To unpack this question, we systematically reviewed 374 scholarly outputs across the CSR and stakeholder dialogue literatures over a 30‐year timeframe. Operating at the intersection of these two literatures, we identify ‘conceptualizations’ of stakeholder dialogue in CSR as either integral (an intrinsic component of CSR) or incidental (a communicative response to CSR), as well as the ‘contours’ (i.e., boundaries) and ‘contexts’ of stakeholder dialogue in CSR. In doing so, we posit that the key to generating effective stakeholder dialogue for business and society lies not only in greater cohesion between CSR and stakeholder dialogue literatures, but in practicing dialogue that is ongoing, stakeholder (rather than firm) focused and avoids idealization. Herein, we stimulate a research agenda for scholars interested in communication and CSR at a time when the social and environmental demands placed on firms continue to escalate.
The interplay of surface stability and oxygen vacancy dynamics in RE2Si2O7‐based environmental barrier coatings
Authors: Fan Yun , Bai Yuelei , Zhao Juanli , Sha Simiao , Li Yiran , Li Qian , Li Wenxian , Liu Bin
Published: January 2024

Surface structure and relevant oxygen vacancy play an important role in the application of RE2Si2O7 for environmental barrier coatings, in which the oxygen vacancies in RE2Si2O7 may influence their thermal and optical properties. In this work, the structure and thermodynamics of (0 0 1) and (1 1 0) surfaces of RE2Si2O7 (RE = Yb, Lu) are studied via first‐principles calculations to reveal the underlying mechanism of the surface formation and the associated oxygen vacancy behavior. The (1 1 0) surface is preferred energetically, being in good agreement with the experiential results. It is uncovered that the weak chemical bond broken dominates the decrease of the surface energy, together with the contribution from the polyhedral distortion. Furthermore, the [O3Si–O–SiO3] site is found to be the preferred site for oxygen vacancies on (1 1 0) surface. The formation energies of oxygen vacancies on the (1 1 0) surfaces are lower than those in the bulk, suggesting their segregation on the surfaces. These findings provide essential insights into the surface excitation and oxygen vacancy behaviors of RE2Si2O7, which could shield light on the experimental improvement of the thermal, mechanical, and corrosion properties for RE2Si2O7‐based environmental barrier coating materials.
Ultrafast charge‐discharge and enhanced energy storage properties of lead‐free K0.5Na0.5NbO3‐based ceramics
Authors: Gao Tingting , Chen Qifan , Li Xu , Lang Rong , Tan Zhi , Li Qinyu , Tang Zhengxian , Xing Jie , Zhu Jianguo
Published: January 2024

For dielectric capacitors in pulsed power systems, ultrafast charge‐discharge rates and good energy storage performances are essential. The relatively low efficiency η and the low energy density of potassium sodium niobate ceramics will restrict their applications. In this work, a local distortion of the crystal structure of ceramics is made by introducing the Bi and Ce ions, promoting the growth of polar nano‐regions, resulting in more obvious relaxation behavior and lower remnant polarization Pr. The average grain size is reduced, further increasing of breakdown strength. Eventually, fine comprehensive energy storage performances and good mechanical properties are simultaneously obtained. Enhanced recoverable energy storage density Wrec (∼5.30 J/cm3) and a high energy storage efficiency η (∼76.81%) are achieved in 0.970(K0.5Na0.5)NbO3‐0.030CeBiO3 (KNN‐0.030CB) ceramics with an ultrafast discharge rate t0.9 (31 ns) and a high current density (1008.5 A/cm2). All of these results indicate that this work provides a resultful way to design excellent comprehensive properties for advanced energy storage materials.
Recent progress in carbide‐based composite materials fabricated by laser additive manufacturing processes
Authors: Ebrahimnezhad‐Khaljiri Hossein , Ghadi Aliakbar
Published: January 2024

Fabricating and introducing new materials with new features is one of the most important goals for many scientific groups. Today, additive manufacturing (AM) is known as one of the new production methods, which can create an excellent opportunity for achieving this goal. As one of the ongoing production processes, the laser AM (LAM) methods have the proper capacity for producing new advanced materials like carbide, nitride, and boride‐based materials. Hence, this work aims to review carbide‐based materials produced by LAM techniques with the composite viewpoint. These materials can act as a matrix, reinforcement, or tertiary component in advanced composites. With this viewpoint, these composite materials were introduced in eight separate sections, which are tungsten carbide, titanium carbide, silicon carbide, niobium carbide, chrome carbide, vanadium carbide, and boron carbide, as well as high entropy alloy composites.
Social deprivation and diabetic kidney disease: A European view
Authors: Casey Caoimhe , Buckley Claire M , Kearney Patricia M , Griffin Matthew D , Dinneen Sean F , Griffin Tomás P
Published: January 2024

There is a large body of literature demonstrating a social gradient in health and increasing evidence of an association between social deprivation and diabetes complications. Diabetic kidney disease (DKD) increases mortality in people with diabetes. Socioeconomic deprivation is increasingly recognized as a modifier of risk factors for kidney disease but also an independent risk factor itself for kidney disease. This may not be truly appreciated by clinicians and warrants further attention and exploration. In this review we explore the literature to date from Europe on the relationship between social deprivation and DKD. The majority of the studies showed at least an association with microalbuminuria, an early marker of DKD, while many showed an association with overt nephropathy. This was seen across many countries in Europe using a variety of different measures of deprivation. We reviewed and considered the mechanisms by which deprivation may lead to DKD. Health related behaviors such as smoking and suboptimal control of risk factors such as hypertension, hyperglycemia and elevated body mass index (BMI) accounts for some but not all of the association. Poorer access to healthcare, health literacy, and stress are also discussed as potential mediators of the association. Addressing deprivation is difficult but starting points include targeted interventions for people living in deprived circumstances, equitable roll out of diabetes technology, and flexible outpatient clinic arrangements including virtual and community‐based care.
Comparative efficacy of oral Janus kinase inhibitors and biologics in adult alopecia areata: A systematic review and Bayesian network meta‐analysis
Authors: Husein‐ElAhmed Husein , Husein‐ElAhmed Sara
Published: January 2024

Alopecia areata (AA) is an autoimmune disorder that affects the hair follicles, resulting in patchy recurrent hair loss. A large body of evidence has demonstrated the favourable clinical response of the Janus kinase (JAK) inhibitors and biologics, but a lack of comprehensive comparison among these therapies exists in the current literature. This study aimed to compare their efficacy. A systematic review and meta‐analysis were performed including randomized trials that report the outcomes of the Severity of Alopecia Tool (SALT)50 and/or the mean change in SALT. These articles were pooled and a network meta‐analysis (NAM) was conducted. Based on the surface under the cumulative ranking curve estimates obtained for the mean change in SALT score, baricitinib_4 mg (0.7949656) had the best probability of being the most effective therapy, followed by ritlecitinib_200_50 mg (0.7391906) and ivarmacitinib_4 mg (0.7292594). In contrast, dupilumab, secukinumab, tralokinumab and apremilast were less likely to be effective. Targeting the JAK signalling pathway holds great potential for restoring hair regrowth, albeit the contribution of JAK1, JAK2, JAK3 and TYK2 inhibition to the therapeutic effect on AA is apparently different. Baricitinib_4 mg and ritlecitinib 200_50 mg demonstrated notable efficacy, and both molecules displayed a dose‐dependent effect, which is not observed with ivarmacitinib. Further investigations into the specific mechanisms of action of these JAK inhibitors are warranted to elucidate the reasons behind these differences.
Clinicopathological definition, management and prognostic value of mogamulizumab‐associated rash and other cutaneous events: A systematic review
Authors: Avallone G. , Roccuzzo G. , Pileri A. , Agostinelli C. , Maronese C. A. , Aquino C. , Tavoletti G. , Onida F. , Fava P. , Ribero S. , Marzano A. V. , Berti E. , Quaglino P. , Alberti‐Violetti S.
Published: January 2024

Mogamulizumab is a first‐in‐class IgG1k monoclonal antibody that selectively targets the chemokine receptor type 4. The drug has received Food and Drug administration authorisation for mycosis fungoides and Sézary syndrome following failure of at least one previous course of systemic therapy and now is available in Europe. One of the most common treatment‐related side effects observed has been the mogamulizumab‐associated rash (MAR), which affects up to a quarter of patients and is the most frequent adverse event leading to drug discontinuation. The aim of this study is to perform a systematic review of the literature on patients diagnosed with MAR and other mogamulizumab‐related cutaneous events to describe the clinical and histological characteristics, the management in clinical practice and to assess whether these events have prognostic implications. In total, 2073 records were initially identified through a literature search, 843 of which were duplicates. After screening for eligibility and inclusion criteria, 49 articles reporting mogamulizumab‐associated cutaneous events were included. Totally, 1516 patients were retrieved, with a slight male prevalence as for the available data (639 males and 570 females, i.e. 52.9% vs. 47.1%). Regarding the reported clinicopathological findings of the cutaneous reactions, the five most common patterns were spongiotic/psoriasiform dermatitis (22%), eruptions characterized by the presence of papules and/or plaques (16.1%), cutaneous granulomatosis (11.4%), morbilliform or erythrodermic dermatitis (9.4%) and photodermatitis (7.1%). Our results highlight how the majority of the reported cutaneous adverse events on mogamulizumab are of mild‐to‐moderate entity and generally manageable in clinical practice, though prompt recognition is essential and case‐by‐case assessment should be recommended. Future research will need to focus on the MAR prognostic implications and to identify genomic and molecular markers for a more rapid and accurate diagnosis.