bluuebunny/crossref_metadata_2025 huggingface dataset:
Price Drivers of Economic Growth in the Southern Region of Russia
Authors:   Plekhanov Russian University of Economics, Gryzunova Natalia , Keri Igor ,   Plekhanov Russian University of Economics, Sizova Darina ,   Plekhanov Russian University of Economics, Sizova Tatyana ,   Plekhanov Russian University of Economics
Published: December 2020

The purpose of this article is to reveal the relationship of the effectiveness of pricing policy and spatial economics. The main emphasis is on export pricing models. International trade contributes to the accumulation of political, social and financial power, forming new shopping centers and unions, aligning prices and profitability. International exchange of strategic resources often has the goal of changing the political landscape and financial and trade practices. Oil and crops are used by leading exporting countries as a tool for political pressure and different kinds of preferences. At the same time, it can be argued that prices for certain strategic commodities in the world market are capable of solving a number of global and national issues. For example, market pricing of oil and oil products is gradually changing the world’s monetary system. Currently, future strategic commodities such as grain, sugar and cotton begin to replace oil. These traditional products of the South of Russia provide a significant share of the revenues of the state budget. However, the investment potential of the companies that produce these resources is extremely low. It is necessary to develop an organizational pricing strategy for the expansion of the product range of companies in the southern region in the MICEX list. Optimal pricing can quantitatively change not only GDP growth of both the global and national economies, but also to change the quality of life and management. Pricing methods (regression, parametric technique, specific indices) and pricing mechanisms (administrative and tax approach, for example) chosen by the company are dynamic market instruments for a strong commodity market, for the redistribution of investment flows, and income for the creation of sources of additional investment on the basis of shareholding.
Industrial Cores of the Economic Framework for Innovative Development of Southern Russian Regions
Authors:   Southern Federal University, Matveeva Lyudmila
Published: December 2020

The imperatives of the spatial development of industry within regions of the South of Russia which have critical demand for innovations formed under the influence of external and internal factors, make necessary the search for new mechanisms that would create regional frameworks for innovation. Thus, taking into account the priority of the industrial sector in the innovative development of the region, the need to identify the borders of the frame of balanced innovation in this area confirms the relevance of the study. This article aims to discover the state and efficiency of using innovative potential of commercial actors that characterize the industrial landscape of the regions of the South of Russia as well as those that form frame matrices. The theoretical and methodological basis of this research is formed on the joint use of the system-synergetic, resource-efficient, process-targeted and endogenous approaches, as well as the combination of theories of industrial development, growth poles, balance and economic framework. In contrast to existing studies, the issue of making the industrial sector of the region innovative is analyzed from the point of view of the formation of an economic framework, the cores of which i.e. the nodes of business activity are the industrial drivers of the central territories, functioning in the cooperation with small and medium-sized innovatively active enterprises of the periphery. In order to achieve a balanced support of the framework for industrial innovation, the implementation of interregional projects, focusing on the creation of innovative clusters, is suggested. The structure of such clusters consists of industrial enterprises, which operate (or are ready for such a work) according to the import substitution model. The research concludes that the forms and scales of influence on the elements of measures in the economic framework that support innovative transformations in industry in certain regions of Southern Russia are determined not only by the state of the resource potential, but also by the specificity of certain territorial determinants, due to which these tasks should be directly connected to the goals of the social and economic development of the area under analysis.
Relações raciais digitais: um estudo sobre as formas de expressão da intolerância racial no Facebook
Authors:   Universidade Federal de Alagoas, Brasil, Fernandes Sheyla , Nascimento Marcikele ,   Universidade Federal de Alagoas, Brasil, Pereira Alanda ,   Universidade Federal de Alagoas, Brasil, Melo Erika ,   Universidade Federal de Alagoas, Brasil, Carlos Kathleen ,   Universidade Federal de Alagoas, Brasil
Published: December 2020

Esta pesquisa tem por objetivo analisar a expressão da intolerância racial no Facebook. Foram selecionados 5 sítios abertos, entre páginas e grupos, no site Facebook por meio do descritor “Racismo” e termos correlatos. Destes, foram coletados os comentários das 5 postagens mais relevantes. Os dados foram transcritos de modo a comporem um corpus textual que foi analisado a partir do software Iramuteq. Os resultados apresentaram 3 eixos principais: o primeiro reporta o reconhecimento do racismo; o segundo remete à importância da representatividade negra; o terceiro aborda a existência de uma democracia racial. Considerou-se relevante discutir a forma pela qual as crenças raciais são expostas no Facebook, reproduzindo manifestações de intolerância, mas também de militância, gerando um discurso que demonstra diferentes faces da segregação racial nesse contexto.
Mining and processing plants: Economic trends and options of corporate governance improvement
Authors:   Sergo Ordzhonikidze Russian State University for Geological Prospecting, Moscow, Russia, Vinslav Yu. B. , Lisov V. I. ,   Sergo Ordzhonikidze Russian State University for Geological Prospecting, Moscow, Russia, Lunkin A. N. ,   Sergo Ordzhonikidze Russian State University for Geological Prospecting, Moscow, Russia, Lunkin D. A. ,   Sergo Ordzhonikidze Russian State University for Geological Prospecting, Moscow, Russia
Published: December 2020

The authors closely consider the economic performance behavior of Russia’s top eight mining and processing plants over the period of a few years. Sustainability of the companies and high demand for their products in the market are highlighted. An important criterion of liquidity position of mining and processing plants (MPP is English for the Russian GOK) is the change in the net assets which have on the whole grown over the period under analysis from 38,5 to 52,8 BRub, i.e., 1.37 times. After a decline in the post-crisis period (2015–2016), the index of the net assets increased by 31 % in 2018. Inventories of all GOKs increased, and the annual average values jumped 2 times (Lebedinsky GOK–2.15 times, Mikhailovsky GOK–2.3 times, Kovdor GOK and Karelski Okatysh–2.4 time, other GOKs–1.2–1.5 times). This proves stability of the liquidity positions of the test companies. A steadily growing trend was observed in buildup of the permanent assets of GOKs: this index of the test companies was 9.6 BRub in 2011 and 22.9 BRub in 2018 (a 2.4 times growth). The highest rate growth was demonstrated by the largest GOKs: Lebedinsky (2.8 times), Stoilensky (3.4 times) and Kovdor (2.1 times). At the same time, there is a downward trend in profitability of the test GOKs, which, by the authors’ opinion, dictates the corporate governance improvement. Efficiency of the corporate governance and competitive ability of a company drastically depend on: capacity of equipment in each process stage; quality of interaction between process stages; balance of capacities of process stages; high-skilled staffing level of each link in the production chain; efficiency of management; quality of information accumulation of current data on the behavior of each production chain link.
Optimization of groundwater monitoring network in terms of mass transfer modeling
Authors:   Belgorod State University, Belgorod, Russia, Agarkov N. B. , Khaustov V. V. ,   Belgorod State University, Belgorod, Russia, Malikov A. M. ,   Belgorod State University, Belgorod, Russia, Karpenko N. G. ,   Belgorod State University, Belgorod, Russia
Published: December 2020

In accordance with the ‘Requirements for Monitoring Solid Mineral Deposits’, groundwater monitoring is carried out in the area of the actual mineral deposit and man-made mining facilities, as well as in the zone of significant influence of the field development and other production activities of mining, which affect the subsoil and other components of the natural environment. The development of an underground water monitoring network using mathematical modeling is shown, the existing monitoring network is analyzed, the model of mass transfer of the main pollutant of underground water is developed, and the predictive calculations of mass transfer are performed. The migration model of the test area was created using MT3D program, which allows 3D modeling of mass processes in the flow of underground water. The boundaries of the model area are determined subject to the outline of the catchment area around the quarry, the project increase in depth and the project cut-back in the quarry, as well as to the presence of natural and man-made sources and facilities which can have influence on groundwater regime. The monitoring system allows regular-based observations toward prediction of changes in the condition of underground waters under the influence of the large-scale water withdrawal and other induced and natural factors. The introduction of such monitoring system can enable prevention of prevention of likely changes in the condition of groundwater and proper adjustment of drainage system operation. The numerical modeling data made it possible to optimize the cost of additional inspection well drilling.
Features of the Development of a Neural Network to Automate the Recognition of Steel Defects
Authors:   Nizhny Tagil Technological Institute (branch) of the Ural Federal University named after the first President of Russia B. N. Yeltsin, Nizhny Tagil, 622031, Russian Federation, Karelova R. A. , Ignatov E. E. ,   Nizhny Tagil Technological Institute (branch) of the Ural Federal University named after the first President of Russia B. N. Yeltsin, Nizhny Tagil, 622031, Russian Federation
Published: December 2020

The article presents an embodiment of an artificial neural network for recognizing defects in images of steel sheets. Several stages of solving the problem are described: the choice of a development environment, a programming language, and libraries necessary for the implementation; features of data analysis, graphing, histograms, finding dependencies; the selection of a suitable neural network, the choice of neural network architecture, the selection of an algorithm for assessing quality and accuracy; neural network spelling; training and checking accuracy and quality, checking for overfitting (retraining). As development tools, Python language, PyTorch library, Jupyter development environment, convolutional neural network architecture — Unet are proposed. Features of the analysis of input images of steel sheets, features of the implementation of the neural network itself are described. The function of binary cross entropy was chosen as a criterion for assessing accuracy, since it seeks to bring the distribution of the network forecast to the target, fine not only for erroneous predictions, but also for uncertain ones. For additional evaluation, the DICE method was also used. The accuracy of the resulting model is 84 %. The proposed solution can become part of a hardware-software system for automating the recognition of defects on metal sheets.
Method for Assessing the Thematic Proximity of Scientific Magazines
Authors:   M. V. Lomonosov Moscow State University, Moscow, 119192, Russian Federation, Kozitsyn A. S. , Afonin S. A. ,   M. V. Lomonosov Moscow State University, Moscow, 119192, Russian Federation, Shachnev D. A. ,   M. V. Lomonosov Moscow State University, Moscow, 119192, Russian Federation
Published: December 2020

The paper describes an algorithm for determining the thematic proximity of magazines. The results of its software implementation can be used to solve the following urgent tasks: clasification of the scientometric indicators values in the evaluation of scientific activity; assessment of the main trends in the development of the main scientific areas; determination of the relationships between data in information systems for constructing ontologies and defining safety rules within the framework of the ABAC model; creation of effective and convenient mechanisms for searching for scientific information. A feature of the presented algorithm is the use of the co-authorship graph for constructing the thematic proximity metric and the ability to process magazines in different languages, which is difficult to implement for other thematic analysis algorithms based on the analysis of full-text information. The software implementation of the presented algorithm is used in practice in the scientometric system "ISTINA".
Uppermost Mantle Velocity beneath the Mid-Atlantic Ridge and Transform Faults in the Equatorial Atlantic Ocean
Authors: de Melo Guilherme W. S. , Parnell-Turner Ross , Dziak Robert P. , Smith Deborah K. , Maia Marcia , do Nascimento Aderson F. , Royer Jean-Yves
Published: December 2020

Seismic rays traveling just below the Moho provide insights into the thermal and compositional properties of the upper mantle and can be detected as Pn phases from regional earthquakes. Such phases are routinely identified in the continents, but in the oceans, detection of Pn phases is limited by a lack of long-term instrument deployments. We present estimates of upper-mantle velocity in the equatorial Atlantic Ocean from Pn arrivals beneath, and flanking, the Mid-Atlantic Ridge and across several transform faults. We analyzed waveforms from 50 earthquakes with magnitude Mw>3.5, recorded over 12 months in 2012–2013 by five autonomous hydrophones and a broadband seismograph located on the St. Peter and St. Paul archipelago. The resulting catalog of 152 ray paths allows us to resolve spatial variations in upper-mantle velocities, which are consistent with estimates from nearby wide-angle seismic experiments. We find relatively high velocities near the St. Paul transform system (∼8.4  km s−1), compared with lower ridge-parallel velocities (∼7.7  km s−1). Hence, this method is able to resolve ridge-transform scale velocity variations. Ray paths in the lithosphere younger than 10 Ma have mean velocities of 7.9±0.5  km s−1, which is slightly lower than those sampled in the lithosphere older than 20 Ma (8.1  km±0.3  s−1). There is no apparent systematic relationship between velocity and ray azimuth, which could be due to a thickened lithosphere or complex mantle upwelling, although uncertainties in our velocity estimates may obscure such patterns. We also do not find any correlation between Pn velocity and shear-wave speeds from the global SL2013sv model at depths <150  km. Our results demonstrate that data from long-term deployments of autonomous hydrophones can be used to obtain rare and insightful estimates of uppermost mantle velocities over hundreds of kilometers in otherwise inaccessible parts of the deep oceans.
Integrating Computer-Assisted Language Learning into ESL Classroom: Formation of Moral and Aesthetic Values
Authors:   RUDN University, Moscow, Russia, Bobunova A. , Sergeeva M. , Notina E.
Published: December 2020

Information and communication technologies (ICT) have given a modern teacher a powerful incentive for his own professional and creative development, as well as improved the quality of educational services provided. The purpose of this paper is to consider revised Bloom’s taxonomy as the way to implement the moral and aesthetic education of students by means of computer-assisted language learning (CALL). The study involved 84 ESL teachers from 10 secondary Moscow schools. The participants were selected from those who engaged students into e-learning effectively. Group 1 (42 participants) was asked to use revised Bloom’s taxonomy to have moral and ethical impact on school children. Group 2 (42 participants) consisted of teachers who had to implement the moral and aesthetic component using ICT on their own. After conducting a semi-structured interview and comparing the collected data of the two groups according to Student’s t-test it was found that most of the participants in group 1 expressed a positive opinion about the introduction of revised Bloom's taxonomy in CALL. The results of the study confirmed that the structuring of electronic resources and students’ activity according to Bloom's objectives leads to easier implementation of the moral and aesthetic component in CALL.
Modeling and Analyzing of Emergency Vehicle Preemption in a Four-phase Intersection via TPN
Authors:   School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China, Pei Yandong , Huang Bo , Zhao Chunxia , Zhang Gongxuan , Hao Jiangen , Qiao Yan
Published: December 2020

Emergency vehicles (EVs) play an important role in public service. And the EV’s timeliness and safety are very important. Focusing on the switch of the phases in a four-phase intersection, this paper presents a novel phase-changing model based on timed Petri nets (TPNs) for the traffic light system and proposes a method that uses TPNs to model the preemption of emergency vehicles in such an intersection. Our model ignores many actual details. By controlling the phases, our method ensures that the EVs can pass through the intersection with no or less delay, and the safety of the traffic model on emergency scene can be ensured. To our knowledge, we are the first to employ TPNs to model EV system on a four-phase intersection. The liveness and reversibility of such a TPN model are also verified through the reachability graph of the TPN.
Collective and Family Memory in the Context of “I and Others” Interaction
Authors:   Saratov State University, Ryaguzova Elena V.
Published: December 2020

The article presents the results of theoretical analysis of the “collective memory” constructs as a repository of collective experience of a large group, represented in the meanings, symbols, images, cultural patterns, means, mechanisms of reproduction and translation of the past, and the “family memory” constructs as its kind in the context of a small group. We believe, that collective and family memory act as specific ontological support that allows actors to establish order and harmony in the society, understand the principles of its life organization, construct social and cultural identity, determine the existential meaning, trajectory and strategy of a person’s life, preserve the configuration of key values and transmit them to the next generations. The purpose of the study is to determine the specific features of collective and family memory as phenomena arising from the interaction of I and the Other/Others. The main research method is the theoretical self-reflection of collective and family memory in the context of the interaction of I and the Other. We assert that collective memory is a generalized and controlled memory of Others, whose dominant function is the preservation of the integrity and security of a large group, while family memory is a communicative memory based on the effect of sympathy and participation of the lived, experienced and spoken experience of a Significant Other – a small group representative. The applied aspect of the problem under study is to use the results of the theoretical self-reflection in developing the basics of the memory policy and commemorative practices, managing the past and resolving memory conflicts within the framework of the Great History discourse, and also forming meta-settings of family system members in relation to their own real and effective family history.
On Understanding the Administrative Law Subject
Authors:   Associate Professor of the Department of Economic Theory and Management of the Russian University of Transport Associate Professor of the Department of Theory and History of State and Law of the Moscow S.U. Witte University PhD (Law), Ordina Olga N.
Published: December 2020

In the administrative and legal science there is a refinement, change and expansion of the subject of the dynamic branch of administrative law, aimed at eliminating the resulting lag of legal theory from the legal reality. In our view, of the three basic categories that characterize the subject of administrative law, “public administration”, “executive power” and “administrativepublic activity”, the main generalization category is the category “administrative and public activities”. The phenomenon of the subject of administrative law refracts the problems and discussions inherent in the industry as a whole. In view of the existence of different points of view on the subject of administrative law, the legal science has not yet formulated a single definition of it. There is a tendency to overcome the conflict between different types of understanding, to bring together the positions of different concepts of understanding of administrative law in order to form a “universal” concept of it, to develop its common concept.
The Principles of Service Disciplinary Proceedings
Authors:   Associate Professor of the Department of Theory of State and Law, Constitutional and Administrative Law of the South Ural State University PhD (Law), Associate Professor, Leschina Eduard L.
Published: December 2020

The article discusses the concept and importance of the principles of disciplinary proceedings. The existing points of view on determination of types of the principles of production on disciplinary cases are allocated and analyzed. Bringing together a number of approaches, the author proposes a two-level system of principles of disciplinary proceedings – General and special.
The Right to Effective Management in the Practice of the European Court of Human Rights
Authors:   Judge of the Pravoberezhny District Court of Lipetsk PhD (Law), Klyuchnikov Andrey Yu. , Kruzhilin Vladimir S. ,   Associate Professor of the Department of Administrative and Financial Law of the Lipetsk Branch of the Russian Presidential Academy of National Economy and Public Administration PhD (Law)
Published: December 2020

The article is devoted to the study of the right to effective management recognized by the international justice as a complex interdisciplinary institution affecting the functioning of public authorities and local self-government, officials and courts. The authors study the principles of the right to effective management, the powers granted to persons in connection with the action of the Institute, taking into account the practice of the ECHR.
Administrative Law Aspects of Keeping Domestic Cats in the Russian Federation
Authors:   Honored Worker of the Higher School of the Russian Federation Head of the Department of Criminal Procedure, Criminalistics and Legal Informatics of the Immanuel Kant Baltic Federal University LL.D., Professor, Volchetskaya Tatyana S. , Khorkov Viktor N. ,   Honored Worker of Higher Professional Education of the Russian Federation PhD (Law), Associate Professor
Published: December 2020

The article is devoted to little-studied issues of administrative and legal regulation of domestic cats in Russia. Particular attention is paid to gaps in the legislative regulation of some aspects of the treatment of one of the most common types of domestic animals — cats.
Administration in Operations of Customs Authorities
Authors:   Associate Professor of the Department of Customs, Administrative and Financial Law of the Saratov State University PhD (Law), Milshina Irina V.
Published: December 2020

The article examines administration as an integral element of the activities of customs authorities. One of the topical areas of customs administration is considered - digitalization and automation of the activities of customs authorities. The problems and prospects of interdepartmental interaction of customs and tax authorities are analyzed.
Responsibility as an Ethical Value
Authors:   Faculty of Law and Administrative Sciences, Stefan cel Mare University of Suceava, Romania, Amanoloae Mihai
Published: December 2020

The individual thinking of each of us causes many of us to give up the utopian dreams of the human mastery over living conditions and the exercise of a new responsibility, in accordance with our new powers. Our ethical responsibility and our fateful ontological choice is to do what is necessary to ensure the continued, worldly integrity of mankind and it's continuity in an indefinite future, to ensure a good continuation of life between communities or even in the relations between the states of the world. We point out as a first example the ecological crisis and the moral crisis of transforming ecological behavior into a habit when humanity needs resources to survive. However, it is necessary to give recognition to researchers who claim that traditional systems of ethics do not have the resources to cope with our unprecedented technological powers, and the effort of all to fill the philosophical void but also the real, tangible and practically proven part of ethics with an "ethics of responsibility", it is something other than a simple daily habit.
POTENSI KANDUNGAN ASETON DARI LIMBAH PUNTUNG ROKOK
Authors:   Teknik Kimia, Fakultas Teknologi Industri, Universitas Islam Indonesia Yogyakarta, Prasetyo Gigih Lintang , Fitriani Sri Endah ,   Teknik Kimia, Fakultas Teknologi Industri, Universitas Islam Indonesia Yogyakarta, Sihotang Dhimas Pratama ,   Teknik Kimia, Fakultas Teknologi Industri, Universitas Islam Indonesia Yogyakarta, Zulkania Ariany ,   Teknik Kimia, Fakultas Teknologi Industri, Universitas Islam Indonesia Yogyakarta
Published: December 2020

Puntung rokok merupakan limbah yang banyak terdapat di lingkungan. Menurut studi laboratorium, dalam rokok terdapat bahan-bahan kimia berbahaya dan logam berat yang dapat mencemari lingkungan. Kandungan kimia pada rokok yang sudah teridentifikasi jumlahnya mencapai 2.500 komponen. Dari jumlah tersebut sekitar 1.100 komponen diturunkan menjadi komponen asap secara langsung dan 1.400 lainnya mengalami dekomposisi atau terpecah, bereaksi dengan komponen lain dan membentuk komponen baru. Sedangkan kandungan kimia dalam asap rokok jumlahnya mencapai 4.800 komponen. Dari berbagai kandungan-kandungan zat yang ada dalam asap rokok yang tidak lolos filter Cambridge, di dalamnya terdapat senyawa aseton sebanyak 100-650 µg per batang rokok yang berpotensi untuk disintesis sehingga dapat menghasilkan suatu produk yang bermanfaat. Penelitian ini bertujuan untuk mengetahui kandungan aseton dalam limbah puntung rokok dengan variabel suhu dan perbandingan katalis dengan tembakau. Limbah puntung rokok diubah menjadi cairan kondesat dengan proses pembakaran menggunakan metode pirolisis. Analisa kandungan aseton dapat diketahui dengan pengujian cairan kondensat menggunakan Gas Chromatoghraphy-Mass Spectrometry. Dengan perbedaan variabel suhu dan perbandingan katalis dengan tembakau akan diperoleh jumlah kandungan aseton yang berbeda. Keterbatasan yang dihadapi oleh peneliti adalah tidak adanya alat untuk menangkap dan menyimpan gas hasil pirolisis yang tidak terkondensasi.
The Relationship Between Personality Types and Sexual Dysfunction
Authors: Hosseini Fatemeh , Beygi Zahra , Yazdanpanahi Zahra , Akbarzadeh Marzieh
Published: December 2020

Background:

Sexual function is affected by various physiological and psychological factors. Individual
differences and various personality types are effective in response to sexual function.

Objective:

The present study aimed to investigate the correlation between sexual function and personality types among the
women referred to healthcare centers in Shiraz in 2014-2015.

Methods:

This cross-sectional, descriptive-analytical study was conducted on 514 women referred to healthcare centers in
Shiraz. The study data were collected using a demographic information form, Female Sexual Function Index, and NEO
Personality Inventory. Written informed consent forms were also obtained from the participants. After all, the data were
analysed through the SPSS software, version 19, using t-test, chi-square test, and Fisher’s exact test.

Results:

The results showed that sexual desire disorder in 39% of the participants, sexual arousal disorder in 38.6%,
orgasm disorder in 25.5%, and sexual pain in 33%. The results also indicated that sexual desire, arousal, and pain were
significantly associated with extroversion and reversely related to neuroticism.

Conclusions:

The score of extroversion was higher in the individuals without sexual dysfunction, while the score of
neuroticism was higher among those with sexual dysfunction. Therefore, it is necessary to evaluate the women’s
personality types as a technique for assessment of sexual dysfunction.
Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 Inhibitor: Plausible Lead for Alzheimer’s Disease
Authors: Jain Priti , Wadhwa Pankaj K. , Jadhav Hemant R.
Published: December 2020

Alzheimer’s disease is one of the most common neurodegenerative disorder afflicting a
large mass of population. BACE-1 (β-secretase) is an aspartyl protease of the amyloidogenic pathway
considered responsible for Alzheimer’s disease (AD). Since it catalyzes the rate-limiting step of
Aβ-42 production from amyloid precursor protein (APP), its inhibition is considered a viable therapeutic
strategy. We have reported the design of small molecular weight compounds supposed to be
blood brain permeable as BACE-1 inhibitors. The clue for the design of this series is drawn from the
previously designed series from our research group.

Objective:

Design and synthesis of 2,4,6-substituted pyrimidine derivatives has been reported. In
vitro FRET-based screening of synthesized derivatives was performed to evaluate the BACE-1 inhibition
profile.

Methods:

Based on the docking simulation studies, a library of derivatives was designed, synthesized
and evaluated for BACE-1 inhibition in-vitro. The docking studies were performed on Glide
(Schrodinger suite) and Molegro virtual docker. Theoretical toxicity was predicted using Osiris
Property Explorer. The synthesized compounds were tested for BACE-1 inhibition using in vitro
assay based on Fluorescence Resonance Energy Transfer technique. The percent inhibition was calculated
as a measure of activity.

Results:

The designed compounds revealed strong interactions with the desired amino acids of
BACE-1 active sites. The aromatic rings placed at the fourth and sixth position of the pyrimidine ring
occupied S1 and S3 substrate-binding clefts while the amino group formed hydrogen bonding interactions
with Asp32 and Asp228. In silico data ensured that the compounds were orally bioavailable
and brain permeable. The in vitro testing showed that the compounds inhibited BACE-1 at 10μM
concentration.

Conclusion:

Compounds substituted with m-benzyloxy on one aromatic ring and o,p-di-chloro on
another aromatic ring displayed maximum BACE-1 inhibition. Compound 2.13A displayed high
docking score and was found to be most potent with IC50 of 6.92μM. The series displayed a good
correlation between the docking score and BACE-1 inhibition profile.
Therapeutic and Protective Potential of Mesenchymal Stem Cells, Pharmaceutical
Agents and Current Vaccines Against COVID-19
Authors: Rasouli Mehdi , Vakilian Fatemeh , Ranjbari Javad
Published: December 2020

:

It has been almost 18 months since the first outbreak of COVID-19 disease was reported
in Wuhan, China. This unexpected devastating phenomenon, raised a great deal of concerns and
anxiety among people around the world and imposed a huge economic burden on the nations’
health care systems. Accordingly, clinical scientists, pharmacologists and physicians worldwide
felt an urgent demand for a safe, effective therapeutic agent, treatment strategy or vaccine in order
to prevent or cure the recently-emerged disease. Initially, due to the lack of specific pharmacological
agents and approved vaccines to combat the COVID-19, the disease control in the confirmed
cases was limited to supportive care. Accordingly, repositioning or repurposing current drugs and
examining their possible therapeutic efficacy received a great deal of attention. Despite revealing
promising results in some clinical trials, the overall results are conflicting. For this reason, there is
an urgent need to seek and investigate other potential therapeutics. Mesenchymal stem cells (MSC),
representing immunomodulatory and regenerative capacity to treat both curable and intractable
diseases, have been investigated in COVID-19 clinical trials carried out in different parts
of the world. Nevertheless, up to now, none of the MSC-based approaches has been approved in
controlling COVID-19 infection. Thanks to the fact that the final solution for defeating the pandemic
is developing a safe, effective vaccine, enormous efforts and clinical research have been carried
out.
In this review, we will concisely discuss the safety and efficacy of the most relevant pharmacological
agents, MSC-based approaches and candidate vaccines for treating and preventing COVID-19
infection.
Comparison of Academic Motivation in Different Phases of Optometry Studies
Authors: Buari Noor Halilah , Alim Hendrry Win
Published: December 2020

The changes in motivation cause an impact on students’ behavior related to academic success. The online survey found that a significant variation of academic motivation occurred in four different phases of Optometry studies. The 3rd year preclinical students displayed a lack of motivation compared to other student groups. This indicated changes in learning adaptation for different syllabus and approaches in educational stages. The academic performance correspondent with the students’ motivation as higher motivation gave better academic performance. Thus, understanding students' academic motivation permits educators to improve the educational approaches in teaching and learning to enhance student performance.
Keywords: Motivation; Optometry, Health Sciences, Education
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5i15.2496.
AGE FEATURES OF MOLECULAR-BIOLOGICAL SUBTYPES OF BREAST CANCER
Authors:   Ural State Medical University, Novikova E.A. , Kostromina O.V. ,   Ural State Medical University, Mikhailov D.V. ,   Ural State Medical University, Leontiev S.L. ,   Institute of Medical Cell Technologies, Sazonov S.V. ,   Institute of Medical Cell Technologies
Published: December 2020

Aim. The aim of the study was to determine the presence of peculiarities of the age structure in patients with various surrogate molecular biological subtypes of breast cancer. Materials and research methods. This work analyzes the age-related characteristics of the occurrence of molecular biological subtypes in 499 patients with invasive breast cancer. All cases were divided into 5 molecular biological subtypes based on immunohistochemical studies of hormone receptors, Her2, Ki-67. The average age of the patients was 53.4±0.39 years, the predominant group was patients from 50 to 60 years (37.2% of the total). Research results. In patients under 40 years old, the triple negative subtype prevailed (44.8%). Luminal A subtype prevailed in the groups 51-60 years old (more than 41.4%) and over 60 years old (39.7%). Luminal B (Her2-) subtype was equally found in all age groups.
BALTIC HYDRONYMY OF CENTRAL RUSSIA
Authors:   OLEG D. FEDCHENKO, FEDCHENKO OLEG D.
Published: December 2020

The article presents the linguistic analysis of hydronyms of the Central Russia. The origin is considered of the names of large rivers (more than 100 km long) from the Moscow, Kaluga, Oryol, Yaroslavl, Ivanovo, Vladimir, Ryazan, Kostroma, Tver, Nizhny Novgorod, Vologda regions. The systematization of hydronyms that appeared in the Baltic language environment was carried out. The results indicate that the names of the rivers have an etymology associated with such concepts as a river, channel, stream. The basis for river names are verbs in Present Tense, third person singular, while the lake names stem from verbs in Past Tense, third person singular. It was also discovered that in modern river names, Slavic and Finno-Ugric vowels of the Baltic hydronyms are very common. The suggested approach helps accurately localize the settlements of Slavic and Finno-Ugric tribes in space as well as time. At the same time, the range of Baltic hydronyms turned out wider than it had been expected. The obtained results enable to clarify the archaeological and historical aspects of the life of ancient people in the Central Russia.
ANIMALISTIC CULTURAL CODE ACTUALIZATION IN RUSSIAN AND ENGLISH PHRASEOLOGY
Authors:   Svetlana V. Shustova Perm State University, SHUSTOVA SVETLANA V. , TYAPUGINA ANASTASIYA E. ,   ANASTASIYA E. TYAPUGINA Perm State National Research University
Published: December 2020

This article presents the analysis of the actualization of animalistic code in Russian and English idioms. Idioms provide extremely interesting and diverse material for research in such fields as ethnolinguistics, contrastive phraseology, cultural linguistics, intercultural communication. Zoomorphic or animalistic cultural code is the complex of notions of the animal world, nominathemes of animals and other living creatures, representing them as a whole or as their parts, and the specific characteristics which complement their natural features by functionally significant cultural meanings. The article proposes a method of linguocultorological analysis of phraseological units containing animalisms. This method was used to examine idioms with 2 zoonym components 1) bull and 2) duck selected from dictionaries, internet resources and corpora. Three idioms including each component were found in 450 contexts. The analysis of idioms including first component showed a complete match of meaning and partial match of form for the first idiom, a complete match of both meaning and form for the second idiom and a complete match of meaning and a total mismatch of form for the third idiom. 2 out of 3 idioms with the second component demonstrated a complete match of meaning and form, while one of them was characterized by only partial match of meaning and a total mismatch of form.
CLARIFICATION ON THE TERM “FRANCIAN”
Authors:   LYDIA ANATOLIEVNA STANOVAÏA Herzen State Pedagogical University of Russia, STANOVAÏA LYDIA ANATOLIEVNA
Published: December 2020

The extremely critical attitude to the traditional history of the French language and the understanding of the Franciеn dialect as the dialect basis for the formation of the French National Language led to the emerging of some factual errors that could not be doubted due to the authority of foreign scientists who introduced this information into scientific use. The study of the authorship of the term ‘francien’ showed that it was not G. Paris who invented and introduced this new term into romanistics. The analysis showed that the new term arose as a result of P. Monet's translation from German to French and first appeared not in 1889, but in 1891.
THE PRESENT LANGUAGE SITUATION IN THE XINJIANG UYGUR AUTONOMOUS REGION (PRC) WITH THE PARTICIPATION OF THE RUSSIAN LANGUAGE: QUANTITATIVE CHARACTERISTICS
Authors:   SERGEY V. GORDEEV National Research Tomsk Polytechnic University Heihe University, GORDEEV SERGEY V. , OGLEZNEVA ELENA A. ,   ELENA A. OGLEZNEVA  National Research Tomsk Polytechnic University
Published: December 2020

The language situation is one of the key concepts of sociolinguistics. Various conditions of the formation of a particular language situation determine its originality and singularity. The description of each specific language situation is necessary with a holistic typological description of language situations. In this paper, the focus is made upon the present language situation of the Xinjiang Uygur Autonomous Region - the largest administrative-territorial unit of the PRC. The Interest in this language situation was sparkled by its uniqueness, extraordinary ethnic and linguistic heterogeneity. In addition, it is Xinjiang that hosts the largest Russian-speaking diaspora in comparison with other regions of China. This study is aimed to analyze the quantitative characteristics of the present language situation of the Xinjiang Uygur Autonomous Region whose integral part is the Russian language. The study has found the number of idioms functioning in the region, their demographic and communicative power, as well as the number of functionally dominant idioms of the present-day language situation in the XUAR, which as a result determine its quantitative characteristics. In addition, the place of the Russian idiom among other idioms of the analyzed language situation has been revealed.
SEMANTIC ASPECT OF ENGLISH NEOLOGISMS WITH GENDER COMPONENT IN MEANING
Authors:   Irina G. Ishchenko Amur State University, ISHCHENKO IRINA G. , FILONOVA OLGA S. ,   OLGA S. FILONOVA Amur State University
Published: December 2020

The article presents the results of semantic analysis of English neologisms with the gender component in their meaning which were registered in lexicographic resources during the XXI century (100 units). The research resulted in distinguishing several thematic groups of new words that characterize men and women according to various parameters: appearance, family relations, professional activity, spheres of interests and others. The obtained results enabled to come to conclusion that social conscience and public worldview affected the process of formation of new lexical items that reflect the changing male and female features and their attitude to the reality. Componential analysis revealed evaluative component in the meaning of some new words, most of which present the negative characteristics of men. This paper also examines gender marked neologisms functioning (2427 tokens) in electronic mass media (450 articles) and demonstrates their wide circulation in various articles. Emerging of gender-marked neologisms and their use can be the evidence of the changes in the perception of gender roles in the society and, correspondingly, in the linguistic picture of the world.
ANTIOXIDANT ACTIVITY OF RAW MILK AND MILK PROTEIN FRACTIONS
Authors:   Federal Scientific Agroengineering Center VIM, CHUMAKOVA IRINA , DONSKAYA GALINA , DOBRIYAN EKATERINA , DROZHZHIN VIKTOR
Published: December 2020

Compounds with antioxidant properties act as stabilizers of biological membranes and prevent the development of free-radical chain processes that lead to the development of severe diseases. Cow’s milk shows antioxidant activity due to whey proteins. Heat treatment used in dairy production technology can inhibit the antioxidant properties of milk proteins. Preserving the natural properties of milk is an urgent task. (Research purpose) The research purpose is in studying the antioxidant activity of raw milk and protein fractions isolated from it with optimal preservation of the activity of whey proteins. (Materials and methods) Authors received raw milk from an individual farm in the Moscow region. The physicochemical parameters of milk and whey were assessed by standardized methods; the fractional composition of proteins was assessed by high-performance liquid chromatography; and the antioxidant activity (total content of water-soluble antioxidants) of milk and protein fractions isolated from it assessed by amperometric method. Milk proteins were coagulated using rennet and calcium chloride. Protein fractions were separated by centrifugation (15,000 revolutions per minute) for 90 minutes. (Results and discussion) The article presents the physical and chemical parameters of raw whole and skimmed milk. The fractional composition of native serum proteins with a predominance of beta-lactoglobulin was studied. The method of milk protein isolation by rennet-calcium method was worked out at a minimum temperature of 38-40 degrees Celsius. (Conclusions) The article presents the composition of raw milk. The article presents the developed optimal conditions for isolation of native proteins from raw skim milk. The antioxidant activity of raw milk, casein fraction and whey was assessed. To maximize the preservation of the antioxidant activity of biologically active whey proteins, it is necessary to reduce the generally accepted pasteurization temperatures of milk (75-95 degrees Celsius), while at the same time searching for new methods of decontamination of milk from foreign microflora.
CALCULATION OF CORONA DISCHARGE PARAMETERS FOR MULTI-WIRE LIGHTNING PROTECTION
Authors:   Belgorod State Agricultural University named after V.Ya. Gorin, VENDIN SERGEY , SOLOV’EV SERGEY , KILIN STANISLAV , YAKOVLEV ALEXEY
Published: December 2020

The article presents the results of theoretical calculating the parameters of a corona discharge when protecting the territory of substations from direct lightning strikes using multi-drop lightning protection. The parameters of the corona discharge are important when calculating the energy losses in the wires of overhead power lines in bad weather. (Research purpose) The research purpose is in developing a computational model and analyze the processes of lightning protection of a substation by placing parallel grounded cables suspended on supports that are placed outside the substation territory. (Materials and methods) The solution is based on a well-known relation for a typical dipole model of a charged thundercloud cell. (Results and discussion) The article present the calculated theoretical dependences, mathematical formulation and algorithm for numerical calculation of the two-dimensional problem that form the basis for calculating multi-wire lightning protection, as well as the calculation results of cable lightning protection of a transformer substation based on two-dimensional numerical modeling and comparison of the results of calculations using analytical expressions with the results of two-dimensional numerical modeling. Despite the noticeable difference between the limit currents calculated by different methods, the difference between the average current between them is small compared to the currents themselves, so one can use its arithmetic mean to determine the actual current. (Conclusions) The obtained results allow to take into account changes in the parameters of the corona formed in the electric field of a thundercloud along its cable length due to its sag, since such changes in the input parameters have a noticeable effect on the corona process, in some cases it is more significant than the effect associated with the actual sag of the cables.