bluuebunny/crossref_metadata_2025 huggingface dataset:
White Matter Changes as an Independent Predictor of Alzheimer’s Disease
Authors: Yan Yibing , Wu Yue , Xiao Guixian , Wang Lu , Zhou Shanshan , Wei Ling , Tian Yanghua , Wu Xingqi , Hu Panpan , Wang Kai
Published: May 2023

Background:

Abnormalities in white matter (WM) may be a crucial physiologic feature of Alzheimer’s disease (AD). However, neuroimaging’s ability to visualize the underlying functional degradation of the WM region in AD is unclear.

Objective:

This study aimed to explore the differences in amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) in the WM region of patients with AD and healthy controls (HC) and to investigate further whether these values can provide supplementary information for diagnosing AD.

Methods:

Forty-eight patients with AD and 46 age-matched HC were enrolled and underwent resting-state functional magnetic resonance imaging and a neuropsychological battery assessment. We analyzed the differences in WM activity between the two groups and further explored the correlation between WM activity in the different regions and cognitive function in the AD group. Finally, a machine learning algorithm was adopted to construct a classifier in detecting the clinical classification ability of the values of ALFF/ALFF in the WM.

Results:

Compared with HCs, patients with AD had lower WM activity in the right anterior thalamic radiation, left frontal aslant tract, and left forceps minor, which are all positively related to global cognitive function, memory, and attention function (all p < 0.05). Based on the combined WM ALFF and fALFF characteristics in the different regions, individuals not previously assessed were classified with moderate accuracy (75%), sensitivity (71%), specificity (79%), and area under the receiver operating characteristic curve (85%).

Conclusion:

Our results suggest that WM activity is reduced in AD and can be used for disease classification.
Association of Alcohol Consumption with Cognition in Older Population: The A4 Study
Authors: Nallapu Bhargav T. , Petersen Kellen K. , Lipton Richard B. , Grober Ellen , Sperling Reisa A. , Ezzati Ali
Published: May 2023

Background:

Alcohol use disorders have been categorized as a ‘strongly modifiable’ risk factor for dementia.

Objective:

To investigate the cross-sectional association between alcohol consumption and cognition in older adults and if it is different across sexes or depends on amyloid-β (Aβ) accumulation in the brain.

Methods:

Cognitively unimpaired older adults (N = 4387) with objective and subjective cognitive assessments and amyloid positron emission tomography (PET) imaging were classified into four categories based on their average daily alcohol use. Multivariable linear regression was then used to test the main effects and interactions with sex and Aβ levels.

Results:

Individuals who reported no alcohol consumption had lower scores on the Preclinical Alzheimer Cognitive Composite (PACC) compared to those consuming one or two drinks/day. In sex-stratified analysis, the association between alcohol consumption and cognition was more prominent in females. Female participants who consumed two drinks/day had better performance on PACC and Cognitive Function Index (CFI) than those who reported no alcohol consumption. In an Aβ-stratified sample, the association between alcohol consumption and cognition was present only in the Aβ– subgroup. The interaction between Aβ status and alcohol consumption on cognition was not significant.

Conclusion:

Low or moderate consumption of alcohol was associated with better objective cognitive performance and better subjective report of daily functioning in cognitively unimpaired individuals. The association was present only in Aβ– individuals, suggesting that the pathophysiologic mechanism underlying the effect of alcohol on cognition is independent of Aβ pathology. Further investigation is required with larger samples consuming three or more drinks/day.
Genome-Wide Mapping Implicates 5-Hydroxymethylcytosines in Diabetes Mellitus and Alzheimer’s Disease
Authors: Beadell Alana V. , Zhang Zhou , Capuano Ana W. , Bennett David A. , He Chuan , Zhang Wei , Arvanitakis Zoe
Published: May 2023

Background: Diabetes mellitus (DM) is a recognized risk factor for dementia. Because DM is a potentially modifiable condition, greater understanding of the mechanisms linking DM to the clinical expression of Alzheimer’s disease dementia may provide insights into much needed dementia therapeutics. Objective: In this feasibility study, we investigated DM as a dementia risk factor by examining genome-wide distributions of the epigenetic DNA modification 5-hydroxymethylcytosine (5hmC). Methods: We obtained biologic samples from the Rush Memory and Aging Project and used the highly sensitive 5hmC-Seal technique to perform genome-wide profiling of 5hmC in circulating cell-free DNA (cfDNA) from antemortem serum samples and in genomic DNA from postmortem prefrontal cortex brain tissue from 80 individuals across four groups: Alzheimer’s disease neuropathologically defined (AD), DM clinically defined, AD with DM, and individuals with neither disease (controls). Results: Distinct 5hmC signatures and biological pathways were enriched in persons with both AD and DM versus AD alone, DM alone, or controls, including genes inhibited by EGFR signaling in oligodendroglia and those activated by constitutive RHOA. We also demonstrate the potential diagnostic value of 5hmC profiling in circulating cfDNA. Specifically, an 11-gene weighted model distinguished AD from non-AD/non-DM controls (AUC = 91.8%; 95% CI, 82.9–100.0%), while a 4-gene model distinguished DM-associated AD from AD alone (AUC = 87.9%; 95% CI, 77.5–98.3%). Conclusion: We demonstrate in this small sample, the feasibility of detecting and characterizing 5hmC in DM-associated AD and of using 5hmC information contained in circulating cfDNA to detect AD in high-risk individuals, such as those with diabetes.
Age-Associated UBE2O Reduction Promotes Neuronal Death in Alzheimer’s Disease
Authors: Cheng Jing , Zheng Huancheng , Liu Chenyu , Jin Jiabin , Xing Zhenkai , Wu Yili
Published: May 2023

Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease leading to dementia in the elderly. Ubiquitin proteasome system (UPS) is critical for protein homeostasis, while the functional decline of UPS with age contributes to the pathogenesis of AD. Ubiquitin-conjugating enzyme E2O (UBE2O), an E2-E3 hybrid enzyme, is a major component of UPS. However, its role in AD pathogenesis has not been fully defined. Objective: We aimed to identify the age-associated expression of UBE2O and its role AD pathogenesis. Methods: Western blot analysis were used to assess expression of UBE2O in organs/tissues and cell lines. Immunofluorescence staining was performed to examine the cellular distribution of UBE2O. Neuronal death was determined by the activity of lactate dehydrogenase. Results: UBE2O is highly expressed in the cortex and hippocampus. It is predominantly expressed in neurons but not in glial cells. The peak expression of UBE2O is at postnatal day 17 and 14 in the cortex and hippocampus, respectively. Moreover its expression is gradually reduced with age. Importantly, UBE2O is significantly reduced in both cortex and hippocampus of AD mice. Consistently, overexpression of amyloid-β protein precursor (AβPP) with a pathogenic mutation (AβPPswe) for AD reduces the expression of UBE2O and promotes neuronal death, while increased expression of UBE2O rescues AβPPswe-induced neuronal death. Conclusion: Our study indicates that age-associated reduction of UBE2O may facilitates neuronal death in AD, while increasing UBE2O expression or activity may be a potential approach for AD treatment by inhibiting neuronal death.
The Effects of Light Therapy for Depression in Dementia: A Systematic Review and Meta-Analysis
Authors: Qu Yi , Zhuang Lin , Zhang Huiying , Liu Chang , Wang Xiaonan
Published: May 2023

Background:

Depression is one of the most common symptoms in patients with dementia.

Objective:

This meta-analysis aimed to evaluate the effect of light therapy on depression associated with dementia by using a single scale.

Methods:

Published studies based on the terms including “Dementia”, “depression”, and “Phototherapy” were searched. Web of Science, PubMed, Embase, CiNii, CNKI, Wanfang Database, and China Biology Medicine disc were adopted to collect randomized controlled studies or cross-controlled studies using the Cornell Scale for Depression in Dementia (CSDD) until February 2022. GRADE and Review Manager Version 5.4.1 were employed to assess the risk of bias. A meta-analysis was conducted by R 4.0.2 software based on the changes in CSDD scores.

Results:

A total of 1,055 studies were retrieved from the databases, and six studies were included after screening. Some 406 people with dementia were included with an average age of over 80 years. Forest plot results showed that light intervention improved depression scores of dementia patients (MD = –2.59, 95% CI: –4.46 to –0.71), and light intensity less than 1,000 lux improved depression symptoms of dementia patients (MD = –2.76, 95% CI: –4.55 to –0.97). An intervention that lasted 8 to 12 weeks was the most effective (MD = –3.77, 95% CI: –6.93 to –0.60), and non-stable interventions such as ceiling LED lights exerted more positive effects (MD = –2.12, 95% CI: –3.38 to –0.85).

Conclusion:

The overall results of the meta-analysis suggested that light intervention can improve the depressive symptoms of older patients with dementia.
Banks of the Superior Temporal Sulcus in Alzheimer’s Disease: A Pilot Quantitative Susceptibility Mapping Study
Authors: Sacchi Luca , Contarino Valeria Elisa , Siggillino Silvia , Carandini Tiziana , Fumagalli Giorgio Giulio , Pietroboni Anna Margherita , Arcaro Marina , Fenoglio Chiara , Orunesu Eva , Castellani Massimo , Casale Silvia , Conte Giorgio , Liu Chunlei , Triulzi Fabio , Galimberti Daniela , Scarpini Elio , Arighi Andrea
Published: May 2023

Background: Brain iron homeostasis is disrupted in neurodegeneration and areas of iron overload partially overlap with regions of amyloid and tau burden in Alzheimer’s disease (AD). Previous studies demonstrated alterations in brain iron accumulation in AD using quantitative susceptibility mapping (QSM). Objective: Here, we investigate brain alterations of QSM values in AD and non-AD patients as compared to healthy controls (HC) in the superior temporal sulcus and its banks (BANKSSTS), one of the top AD-affected regions. Methods: Thirty-four patients who underwent brain MRI including a multi-echo gradient-echo sequence were subdivided into AD (n = 19) and non-AD (n = 15) groups according to their clinical profile, CSF (Aβ42/40) and/or amyloid-PET status. Ten HC were also included. QSM values were extracted from left and right BANKSSTS and compared among groups. Correlation and binomial regression analyses between QSM values and CSF-AD biomarkers were conducted. Results: QSM in left BANKSSTS was significantly different among groups (p = 0.003, H = 11.40), being higher in AD. QSM values in left BANKSSTS were correlated with Aβ42 (rho –0.55, p = 0.005), Aβ42/40 (rho –0.66, p < 0.001), pTau (rho 0.63, p < 0.001), tTau (rho 0.56, p = 0.005), tTau/Aβ42 (rho 0.68, p < 0.001) and pTau/Aβ42 (rho 0.71, p < 0.001). No correlations between QSM values and amyloid-PET SUVR in the left BANKSSTS were found. QSM values in left BANKSSTS showed good accuracy in discriminating AD (AUC = 0.80, CI95 % [0.66–0.93]). Higher QSM values were independent predictors of Aβ42 (B = 0.63, p = 0.032), Aβ42/40 (B = 0.81, p = 0.028), pTau (B = 0.96, p = 0.046), tTau (B = 0.55, p = 0.027), and tTau/Aβ42 (B = 1.13, p = 0.042) positivity. Conclusion: Our preliminary data support the potential role of increased QSM values in the left BANKSSTS as an auxiliary imaging biomarker in AD diagnosis.
Vitreous Humor Biomarkers Reflect Pathological Changes in the Brain for Alzheimer’s Disease and Chronic Traumatic Encephalopathy
Authors: Vig Viha , Garg Itika , Tuz-Zahra Fatima , Xu Jia , Tripodis Yorghos , Nicks Raymond , Xia Weiming , Alvarez Victor E. , Alosco Michael L. , Stein Thor D. , Subramanian Manju L.
Published: May 2023

Background: Patients with eye disease have an increased risk for developing neurodegenerative disease. Neurodegenerative proteins can be measured in the eye; however, correlations between biomarker levels in eye fluid and neuropathological diagnoses have not been established. Objective: This exploratory, retrospective study examined vitreous humor from 41 postmortem eyes and brain tissue with neuropathological diagnoses of Alzheimer’s disease (AD, n = 7), chronic traumatic encephalopathy (CTE, n = 15), both AD + CTE (n = 10), and without significant neuropathology (controls, n = 9). Methods: Protein biomarkers i.e., amyloid-β (Aβ40,42), total tau (tTau), phosphorylated tau (pTau181,231), neurofilament light chain (NfL), and eotaxin-1 were quantitatively measured by immunoassay. Non-parametric tests were used to compare vitreous biomarker levels between groups. Spearman’s rank correlation tests were used to correlate biomarker levels in vitreous and cortical tissue. The level of significance was set to α= 0.10. Results: In pairwise comparisons, tTau levels were significantly increased in AD and CTE groups versus controls (p = 0.08 for both) as well as AD versus AD+CTE group and CTE versus AD+CTE group (p = 0.049 for both). Vitreous NfL levels were significantly increased in low CTE (Stage I/II) versus no CTE (p = 0.096) and in low CTE versus high CTE stage (p = 0.03). Vitreous and cortical tissue levels of pTau 231 (p = 0.02, r = 0.38) and t-Tau (p = 0.04, r = –0.34) were significantly correlated. Conclusion: The postmortem vitreous humor biomarker levels significantly correlate with AD and CTE pathology in corresponding brains, while vitreous NfL was correlated with the CTE staging. This exploratory study indicates that biomarkers in the vitreous humor may serve as a proxy for neuropathological disease.
Performance analysis of Petri net based on moment generating function
Authors: Yang Xu
Published: May 2023

The Petri net structure of workflow is used to model, and the moment generating function is used to analyze the time performance of workflow, and the complexity of analysis is given. It provides basic theory and basis for analysis and verification. The calculation of time complexity is given for sequence, concurrency, cycle, conflict (selection) and mutual exclusion. The performance analysis method based on moment generating function can be used to analyze the performance of arbitrarily distributed bounded or unbounded random Petri nets. Establish a broad-random Petri net model that conforms to the concept of workflow. Then, based on statistical analysis and experience estimation of relevant data in the actual system, analyze the time nature of the on-demand service based on the analysis method based on behavioral expression, and obtain some valuable performance and index information. A necessary and sufficient condition for maintaining reliability of a workflow network model is given; A polynomial decomposition algorithm for P-invariants is proposed; Combining the moment function, a performance analysis method for workflow systems is established. An example is given to verify the effectiveness of the algorithm.
A novel MADM technique based on projection methods under q-rung orthopair fuzzy setting and its application to computer network security evaluation
Authors: Qiao Wenbao
Published: May 2023

Computer network security evaluation is a basic work to determine the security performance of the network system and implement the network security management. It involves organizational management, network technology, personnel psychology, social environment and other factors. In recent years, with the rapid development of information technology in China, the problem of computer network security has become increasingly prominent. Although domestic and foreign scholars have sought effective methods of network security evaluation from different aspects and using different methods, many factors involved in network security are difficult to quantify, so far, there is no relatively mature quantitative evaluation method of network security. The computer network security evaluation is classical multiple attribute decision making (MADM) problems. In this article, based on projection measure, we shall introduce the projection models with q-rung orthopair fuzzy information. First of all, the definition of q-rung orthopair fuzzy sets (q-ROFSs) is introduced. In addition, to fuse overall q-rung orthopair fuzzy evaluation information, two aggregation operators including q-ROFWA and q-ROFWG operators is introduced. Furthermore, combine projection with q-ROFSs, we develop the projection models with q-rung orthopair fuzzy information. Based on developed weighted projection models, the multiple attribute decision making model is established and all computing steps are simply depicted. Finally, a numerical example for computer network security evaluation is given to illustrate this new model and some comparisons between the new proposed models and q-ROFWA and q-ROFWG operators are also conducted to illustrate advantages of the new built method.
A hybrid model for text classification using part-of-speech features
Authors: Zou Wang , Zhang Wubo , Tian Zhuofeng , Wu Wenhuan
Published: May 2023

In the field of text classification, current research ignores the role of part-of-speech features, and the multi-channel model that can learn richer text information compared to a single model. Moreover, the method based on neural network models to achieve final classification, using fully connected layer and Softmax layer can be further improved and optimized. This paper proposes a hybrid model for text classification using part-of-speech features, namely PAGNN-Stacking1. In the text representation stage of the model, introducing part-of-speech features facilitates a more accurate representation of text information. In the feature extraction stage of the model, using the multi-channel attention gated neural network model can fully learn the text information. In the text final classification stage of the model, this paper innovatively adopts Stacking algorithm to improve the fully connected layer and Softmax layer, which fuses five machine learning algorithms as base classifier and uses fully connected layer Softmax layer as meta classifier. The experiments on the IMDB, SST-2, and AG_News datasets show that the accuracy of the PAGNN-Stacking model is significantly improved compared to the benchmark models.
A retrospective comparison of phototherapy need in O–B versus O–A incompatibility in a single Saudi institution
Authors: Al-Omran A.M. , Shapan H.A. , Al-Abdi S.Y.
Published: May 2023

BACKGROUND: ABO incompatibility is a major risk factor for neonatal indirect hyperbilirubinemia (NIH), requiring treatment. It has been shown that there are racial differences in direct antiglobulin test (DAT) positivity and phototherapy need in the O-–B versus (vs) O-–A incompatibility. The comparison between the O-–B and O-–A incompatibility is not well studied in Saudi Arabia. AIMS: We aimed to compare DAT positivity and phototherapy need in O–B vs O–A incompatibility in Saudi Arabia. METHODS: This retrospective cohort study was conducted in one Saudi hospital. We included a convenience sample of neonates born between 01 January 2013 and 31 December 2021. We included healthy neonates admitted to the nursery care unit only, born at≥38 weeks gestation, and had normal G6PD levels. Neonates that had no G6PD level measurement or lost follow-up post-discharge were excluded. The data span was the first 14 days of life. RESULTS: A total of 611 neonates met our inclusion criteria. Positive DAT was more prevalent in the O–B than the O–A incompatibility [43.5% vs 29.2%, p < 0.001). A greater odd of phototherapy need was observed in the O-–B vs O–A incompatibility across various strata. Readmission for NIH, use of 360° exposure phototherapy, or intravenous immunoglobulin administration was more prevalent in the O–B than the O–A incompatibility (13.2% vs 5.0%, p < 0.001). A logistic regression analysis revealed that the O–B incompatibility modified the association between DAT positivity and phototherapy need. CONCLUSIONS: The O–B incompatibility had a mediator effect on the relationship between DAT positivity and the need for phototherapy in the study population, which emphasizes that the O–B and O–A are not the same from the NIH point of view.
Standard Mobile Phones Plus a Balance Board Are Sufficient: Designing a Serious Game for Better Knee Rehabilitation
Authors: Rast Lukas , Baranyi René , Pinter Karl , Hölbling Dominik , Aigner Christoph , Grechenig Thomas
Published: May 2023

The rehabilitation process after knee injuries is often challenging for patients and requires a high level of resilience, as it involves the frequent repetition of mostly monotonous exercises. Based on recent research, serious games can significantly improve motivation by merging exercising with entertainment aspects and even combining it with hardware to apply external tasks and track the progress. The aim of this research is to propose and evaluate a new serious game pattern. The development is performed using systematic feedback from domain experts. The test setup involves analysis of patients’ feedback. The final game comprises an interaction with a balance board and an attached smartphone. Evaluation showed two main results. From a technical point of view: sensors of a standard smartphone (and it’s sensitivity) paired with a PC and its screen are usable in a rehabilitation setting. From a psychological point of view: the motivation to perform the knee rehabilitation process can be enhanced with a serious game delivering entertaining aspects to it.
Transforming Documents of the Austrian Nationwide EHR System into the OMOP CDM
Authors: Korntheuer Raffael Lukas , Katsch Florian , Duftschmid Georg
Published: May 2023

The Austrian nationwide EHR system ELGA can contribute valuable data for research due to its high volume of data and broad population coverage. In order to be applicable in international research projects, transformation to a standardized, research-oriented data model such as the OMOP common data model is essential. In this paper we describe our experience with the corresponding transformation task. Using Python scripts, we implemented a prototypical process that extracts, transforms, maps, and loads fully structured sections of ELGA documents to an OMOP database.
Assessing the Accuracy of the Azure Kinect for Telerehabilitation After Breast Cancer Surgery
Authors: Cattaneo Andrea , Fragasso Mattia , Magni Martina , Mostachetti Ivana , Perri Elisabetta , Vitali Andrea
Published: May 2023

Background: Rehabilitation plays a key role in the recovery of upper extremity function after breast cancer surgery. Motion capture (mocap) systems for serious gaming have shown the potential to enable home-based rehabilitation, but clinical accuracy needs to be examined. Objectives: Validation of markerless mocap systems for telerehabilitation after breast cancer surgical intervention. Methods: The accuracy of the markerless mocap device Azure Kinect in detecting compensatory movements and postural disturbances has been compared to a gold standard Optitrack system in five volunteers. Subsequently, a serious game for mocap-based shoulder exercises has been developed and integrated into a telerehabilitation platform. Results: The Azure Kinect shows good reliability for scapular elevation (ICC >0.80; MAE <2.1 cm) and trunk tilt (ICC=0.88; MAE=5°), moderate reliability for rounded shoulders (ICC=0.51; MAE=2.6cm) and poor reliability for kyphosis angle (ICC=0.22; MAE=18°). Conclusion: The Azure Kinect provides reasonable performance for shoulder rehabilitation. The proposed telerehabilitation platform has been tested by rehabilitation specialists and received positive feedback.
Research Report: Exploring Needs, Impediments and Perspectives for a Digital Mental Health Tool in Psychiatric Settings
Authors: Blaimschein Esther Sophie
Published: May 2023

The COVID-19 pandemic brought forth rapid responses and changes in the acceptance of digital health interventions. Digital solutions appear increasingly promising, yet little is known about the peculiarities in the psychiatric context, contrary to other medical branches. The project MeHealth aimed at disclosing specific needs and reservations of patients and professionals in the psychiatric field. Apprehensions towards technology were found to be held on both sides. Cooperating with a psychiatric hospital in Austria, through a transdisciplinary research approach including focus groups and workshops, a framework for an integrated Digital Mental Health Tool was established. The findings leading to the framework show a strong need for patient-empowerment, enhancement of trust in technology and the need for multi-stakeholder cooperation. Digital tools should be designed to enhance the continuity of care and information exchange on behalf of the patient. Learnings were gained, which prove recommendable for future R&D projects on digitalization in the delicate field of psychiatry.
Sustainability in Healthcare: Methods and Tools for the Assessment
Authors: Savoldelli Anna , Landi Daniele , Rizzi Caterina
Published: May 2023

Background: Healthcare sector has a significant impact on the environment and people well-being. Therefore, it is interesting to understand how healthcare contributes to sustainable development. Objective: The study aims to perform a literature review on the methodologies applied to quantify environmental impact in healthcare with an attention to telemedicine activities. Methods: Scopus and PubMed databases were investigated between 2018 and 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) frameworks was followed for article selection. Results: From initial 183 articles, 50 full-studies were included. Life-cycle assessment method proved to be a standard for assessing the impact of devices used in clinical practice. Indeed, for the investigation of care activities a unique methodology was not defined. The assessment of telemedicine is mainly based on avoided travels, and a standard methodology is still missing. Conclusions: To move toward a sustainable development other aspects of sustainability should be investigated.
Multi-Stakeholder Design for Complex Digital Health Systems: Development of a Modular Open Research Platform (MORE)
Authors: Pakianathan Pavithren V.S. , Wurhofer Daniela , Kumar Devender , Niebauer Josef , Smeddinck Jan
Published: May 2023

Background: The Modular Open Research Platform (MORE) is being developed as an open-source platform for long-term situated digital health (DH) research and observations with the potential to facilitate studies, evaluations of DH interventions, and remote telehealth monitoring. Objectives: To implement an iterative development approach that integrates multi-stakeholder perspectives to support a single platform development process. Method: Capture, fulfil and balance the requirements of a multi-disciplinary group of stakeholders interacting with the system through a Delphi-inspired, iterative and participatory design process encompassing a series of workshops and online surveys. Results: Through interaction with a multi-disciplinary group of key platform stakeholders, diverse feedback and requirements for the design and development process were elicited and integrated. Conclusion: Findings from the initial rounds of stakeholder involvement lay the stepping stone towards further iterations in the process. Experts who participated in the process reported being generally supportive of and feeling involved in the development process.
Evidence-Based and User-Centred Development of an Ecounseling & Learning-System for Parents of Children with ADHD
Authors: Gstöttner Lisa-Sophie , Kerschbaumer Andrea , Hauser Carina , Schönthaler Erna , Szabó Károly , Werner Franz , Putz Peter
Published: May 2023

Attention deficit hyperactivity disorder (ADHD) is one of the most common mental disorders in childhood and adolescence. It is characterized by attention deficit, hyperactivity, and impulsivity as the main symptoms. These can lead to increased stress in everyday life for the entire family. The e-counseling and e-learning application is being developed within the ELSA project to support parents of ADHD-diagnosed children in everyday life. The requirements identified included, for example, advice on children’s restlessness or measures against sibling rivalry.
Telemedicine Research from Big Bang to 2022
Authors: Hackl Werner O. , Neururer Sabrina B. , Pfeifer Bernhard
Published: May 2023

The Clinical Information Systems (CIS) section of the IMIA Yearbook of Medical Informatics systematically screens about 2,500 publications from more than 1,000 journals annually to find the best CIS publications. The editors of the CIS section have noticed a trend toward patient-centered care supported by AI and machine learning and increased research in cross-institutional data sharing, particularly in telemedicine. As a result, they adjusted their search query to include the MeSH term “telemedicine.” As a preliminary step and to get a sense of the historical development of telemedicine research activity, they performed a bibliometric analysis of all previously published papers in PubMed indexed with the tag “Telemedicine” as MeSH Major Topic. They retrieved 29,289 publications from 1976 to 2022 and used their titles and abstracts to create a bibliometric network that visualizes the most relevant terms, their frequency and relationship to each other, and the chronological sequence of their publication. The development over time also shows a clear move toward patient-centeredness. Interestingly, the term “Covid,” which has only recently come into use, takes on a central role in the network.
Workplace mobbing, group cohesion and intraindividual variables in nurses from a rural hospital in Northern Greece: A correlation study
Authors: Varytis Athanasios , Giannouli Vaitsa
Published: May 2023

BACKGROUND: High levels of mobbing are reported in Greek nurses, but the intraindividual and perceived group emotional correlates are little investigated. OBJECTIVE: To determine the relationship between workplace mobbing (specifically in the nursing sector of a public rural hospital in Greece) and emotional correlates. METHODS: Questionnaires measuring emotional aspects such as Negative Act Questionnaire – Revised (NAQ-R) for measuring perceived exposure to bullying and victimization at work, Maslach Burnout Inventory (MBI), Overall Job Satisfaction Scale (OJS), Job Affect Scale (JAS: positive and negative subscales), Perceived Cohesion Scale (PCS), Ethical Climate Questionnaire (ECQ), and Short General Health Questionnaire (GHQ-12) were administered. For the analysis of the data, descriptive and parametric tests were performed through the Pearson correlations and regression for the relationship between variables. RESULTS: High mobbing levels were reported (M = 45.93) compared to already established cutoff scores. Statistically significant positive correlations were found for NAQ-R and MBI (Exhaustion subscale) (r = .569, p < .001), NAQ-R and JAS-negative affect (r = .610, p < .001), NAQ-R and GHQ-12 (r = .280, p = .002), and NAQ-R andeducational level (r = .196, p = .033). Statistically significant negative correlations were found for NAQ-R and ECQ (r = –.323, p < .001), NAQ-R and JAS-positive affect (r = –.556, p < .001), and NAQ-R and PCS (r = –.586, p < .001). Only burnout,negative affect, and perceived group cohesion predicted mobbing measured by NAQ- R. CONCLUSION: As mobbing and its consequences are related to specific emotional variables, these perceived individual and group indices, could be targeted in future prevention initiatives.
Impact of atypical working hours on sleep and mood among healthcare workers
Authors: Ben Said Hanene , Hajjem Lamia , Youssef Imen , Brahim Dorra , Mersni Mariem , Youssfi Imen , Bahri Ghada , Mechergui Najla , Ladhari Nizar
Published: May 2023

BACKGROUND: Atypical working hours have raised serious concerns about health effects, such as sleep disorders and psychological repercussions. These schedules are frequent among health professionals having the obligation to ensure the permanence of health services. OBJECTIVE: To assess the impact of atypical working hours on sleep, sleepiness, and mood among health personnel (HP). METHODS: Comparative descriptive cross-sectional study was carried out among HP of a regional hospital in Southern Tunisia from December 2019 to May 2020. Two groups were defined according to their work schedule: group A had a fixed-day work and group B had atypical working hours. The assessment of sleep, sleepiness, and mood was based respectively on the Spiegel questionnaire, the Epworth Sleepiness Scale, and the Hospital Anxiety and Disorder scale. RESULTS: A total of 101 HP in group A and 135 in group B were included. We found signs of pathological sleep in group B: greater delay in falling asleep (78.1% Vs 53.5%; p = 0.002), altered sleep quality (88.1% Vs 56.4%; p = 0.039), and more frequent occurrence of dreams (37% Vs 31.7%; p = 0.033). The quality of sleep was associated with the professional seniority (p = 0.01), the workplace (p = 0.02), and having dependent children (p = 0.04). The mean score of depression was higher in group B (p = 0.02). Depression was associated with the workplace (p = 0.04) and the quality of sleep (p = 0.01). CONCLUSION: The results of this study indicate that atypical working hours generate both sleep and mood disorders in HP. It is vital to encourage the occupational physicians to estimate sleep and mood disorders in HP.
Prevalence of work-related musculoskeletal disorders among professional rickshaw drivers in Aligarh, Uttar Pradesh, India
Authors: Ali Abdulelah M. , Alam Mohd Mukhtar , Sufyaan Mohd , Ahmad Israr , Zarrin Saima
Published: May 2023

BACKGROUND: Professional rickshaw driving is a seemingly sedentary occupation and involves many risk factors for work-related musculoskeletal disorders (WMSD). OBJECTIVE: To assess the prevalence of work-related musculoskeletal disorders and its associated risk factors among professional rickshaw drivers. METHODS: 263 rickshaw drivers were voluntarily recruited from Aligarh, Uttar Pradesh, India. MSD symptoms in the past 12 months and last 7 days were assessed using a self-modified musculoskeletal questionnaire (Nordic Questionnaire). Chi-square tests and binary logistic regression were performed to analyze associations of MSD symptoms between study variables. RESULTS: 155 (58.9%) study participants reported MSD symptoms in past 12 months, in lower back (n = 126, 81.3%), leg (n = 122, 78.7%), neck (n = 106, 68.4%) and knee (n = 105, 67.7%); and 121 (46.1%) in last 7 days, in leg (n = 107, 88.4%), lower back (n = 102, 84.3%), neck (n = 89, 73.6%), upper back and knees (n = 87, 71.9%). Binary logistic regression showed relationship between working hours, seat and road condition, average load per ride, rickshaw ride duration, and standing driving with MSD symptoms among rickshaw drivers, especially in the lower back, leg/calf muscles, neck and knees. CONCLUSION: The results showed a high prevalence of MSD among all rickshaw drivers, with the neck, lower back, leg/calf muscles and knees being the most affected body parts. In order to avoid adverse effects on the occupational health of rickshaw drivers, ergonomic intervention training is necessary.
Validación de la Escala de Orientación Intrínseca Versus Extrínseca en el Aula para escolares uruguayos
Authors: Cuevasanta Diego , Curione Karina , Ortuño Victor E. C. , Sandin Florencia , Burghi Martina , Vásquez-Echeverría Alejandro
Published: May 2023

Se presenta la validación al español de la Scale of intrinsic versus extrinsic orientation in the classroom adaptada para escolares uruguayos. Participaron del estudio 912 niños (52.4% niñas y 47.6% varones), con un promedio de edad de 10.19 años (DE = 1.10), pertenecientes a 10 Instituciones Educativas (61.4% públicas y 38.6% privadas) de la ciudad de Montevideo, Uruguay. Se analizó la estructura de la escala a través de un Análisis Factorial Confirmatorio, el modelo final presenta adecuados índices de ajuste (χ 2/df = 4.03; CFI = .91; TLI = .90, RMSEA = .06, SRMR = .05). Los resultados obtenidos confirman la estructura original de cinco dimensiones propuesta por Harter y aportan evidencia sobre las adecuadas propiedades psicométricas del instrumento para su uso con población escolar uruguaya. Esto no excluye que futuros estudios deban buscar soluciones para la baja confiabilidad encontrada en la dimensión Curiosidad.
FILOSOFIAS E LEITURAS DECOLONIAIS: NOTAS SOBRE UMA EXPERIÊNCIA PEDAGÓGICA PARA ADIAR O FIM DO MUNDO À LUZ DAS CATEGORIAS DE BEM VIVER E RESISTÊNCIA
Authors: Bittencourt Paulo S. J. , Severo Gerson Egas
Published: May 2023

No presente artigo, são apresentadas reflexões e leituras decoloniais concernentes a aspectos fundamentais das paideias, da ancestralidade e das sabedorias originárias de outras matrizes culturais, especialmente, as da África e do Extremo Oriente Asiático. O ponto de partida referencial é o da experiência acadêmica e pedagógica de disciplina desenvolvida recentemente no âmbito do Curso de Licenciatura em História, na Universidade Federal da Fronteira Sul, Campus Erechim, considerando, para tanto, as categorias chaves de bem viver e de resistência, recepcionadas de debates sobre a questão em contexto da Ameríndia.
NOTAS PARA UMA PEDAGOGIA DA INTERSECCIONALIDADE
Authors: Silva Fernando Guimarães Oliveira da
Published: May 2023

Este texto é oriundo de um projeto de pesquisa preocupado com a luta antirracista por uma educação sul-mato-grossense engajada e como prática de liberdade. Fundamento-me em perspectivas decoloniais, do pensamento interseccional feminista-negro e de concepções freireanas de educação para sugerir a interseccionalidade como ferramenta pedagógica de ensino e de aprendizagem na educação básica, tendo como pano de fundo norteador dos diálogos as minhas experiências vividas, escrevivências e embrutecimentos pedagógicas de minha caminhada em um (c)istema-mundo produtor de precariedade existencial. Como ato conclusivo, busquei atentar-me para o engajamento docente em temáticas que propõem repensar a narrativa histórica única. É um compromisso de diferentes áreas não necessariamente de humanas na educação básica: é possível articular assuntos das ciências exatas e biológicas a partir de temáticas do cotidiano racializado, misógino, produtor de desigualdades e precariedade da vida.
DECOLONIALIDADE NA EDUCAÇÃO ESCOLAR INDÍGENA DO POVO KANELA/MEMORTUMRÉ, MA
Authors: PEREIRA DA SILVA SOLANGE MARIA , Rodrigues Tiago de Aguiar
Published: May 2023

Este artigo tem por objetivo levantar discussões sobre a educação escolar indígena decolonial e apresentar   uma proposta pedagógica para o ensino médio, na aldeia Escalvado do povo Kanela/Memortumré (MA). Para isso foi analisado o Referencial curricular para a educação indígena do Estado do Maranhão, aprovado em 2021. Com base nesse documento, apresentam-se os conteúdos da Base que devem compor os currículos das escolas indígenas, deixando a parte intercultural aberta para que cada escola construa o currículo de acordo com as necessidades de cada comunidade. Dessa maneira, procurou-se apresentar a proposta para um currículo decolonial intercultural, a partir do referencial de Walsh (2009), Paulo Freire (1976,1978) e Macena (2007). Para isso fazemos uma reflexão/discussão sobre decolonialidade e currículo intercultural aplicado à educação escolar indígena, procurou-se enfatizar a abordagem crítica da leitura mobilizada por diversos componentes curriculares para a produção do gênero carta aberta. Foram  apontados alguns encaminhamentos para a prática da interculturalidade e do dialogismo a partir dos conhecimentos da base, contextualizando de acordo com a realidade histórico-social do povo Kanela.
APRENDER A SER E A VIVER COM OS HUNI KUIN: EDUCAÇÃO, IMAGINÁRIO E SENSIBILIDADE NO JOGO “HUNI KUIN - OS CAMINHOS DA JIBÓIA”
Authors: Parteka Thamara , Da Cunha Higor Antonio , Willms Elni Elisa
Published: May 2023

Uma educação decolonial (WALSH, 2013) se constrói a partir do diálogo com práticas e saberes ameríndios e afroamericanos, considerando imaginários, percepções e afetos outros, não delimitados pelo horizonte do colonialismo e da colonialidade, mas que se abra para modernidades outras (DUSSEL, 2005). O objetivo deste trabalho é fazer ver e circular conhecimentos do povo Huni Kuin, seus modos de ser, viver e narrar, a partir do jogo “Huni Kuin: os caminhos da Jibóia” (2016). A metodologia empregada no artigo foi de caráter exploratória (GIL, 2008) e os procedimentos técnicos foram a revisão de literatura, a análise midiática (KELLNER, 2001) e a análise de imaginário (GASI, 2016). Como resultados identificamos que o jogo é uma importante ferramenta para a construção de uma educação estética decolonial (SILVA, 2021), tanto por seus elementos gráficos e audiovisuais, quanto por sua própria elaboração, que se deu a partir da produção partilhada de conhecimento.
ANÁLISIS SOCIOECONÓMICO DE LOS PROCESOS DE DESMANTELAMIENTO DE INSTALACIONES HIDROCARBURÍFERAS DE SUPERFICIE EN ECUADOR
Authors: Villagomez Monteros Paul Danilo , Tenório Fernando Guilherme , Naranjo Efraín
Published: May 2023

La industria de los hidrocarburos continúa creciendo y, en contraste, miles de instalaciones de petróleo y gas en tierra y en alta mar se están acercando a la obsolescencia. En América del Sur ha tenido notoriedad lo desarrollado en Brasil en los últimos años, cuyo objetivo fue construir una metodología para evaluar y ejecutar proyectos de desmantelamiento de instalaciones costa afuera, considerando los aspectos ambientales, sociales, económicos y operativos. Los países con actividades hidrocarburíferas, como el Ecuador, tarde o temprano tendrán que enfrentar el desmantelamiento de manera similar, pero adaptada a su realidad. En este artículo, a partir de una investigación documental, se reflexionó sobre el significado y alcance del desmantelamiento y con base en los fundamentos teóricos de la Gestión Social, se delimitó su dimensión social, advirtiendo que, la decisión de llevar a cabo los proyectos de este tipo debe ser resultado de un proceso deliberativo de la sociedad que priorice el uso adecuado del territorio y el bienestar colectivo.
O RESGATE DO BARROCO
Authors: Dos Santos Júnior Cristóvão José
Published: May 2023

Soneto.
SEM
Authors: Batalha Douglas
Published: May 2023

Poema
O DISCURSO DO ESCOLA SEM PARTIDO PROFERIDO AO PROFESSOR
Authors: Lima Jonas Pereira , Correio Luiza Helena Oliveira da Silva
Published: May 2023

Este texto consiste em uma síntese de uma investigação que teve como objeto de estudo o discurso do Escola sem Partido analisado com base aos parâmetros teórico-metodológico da Semiótica Discursiva. A análise revelou que o sujeito do Escola sem Partido manifesta discurso intolerante quando impõe que o professor seja neutro em relação aos aspectos políticos, ideológicos, partidários, religiosos, morais e de identidade de gênero supostamente discutidos em sala de aula. Mediante análises e resultados, constatamos que o Escola sem Partido assume uma postura autoritária em favor de uma corrente política, que despreza o ensino e aprendizagem pluralista e crítico, estimulando a prática da intolerância ao professor. Em seu discurso, construído pela regularidade das enunciações, vozes intolerantes se articulam para instigar as paixões disfóricas do ódio e do medo, que reverberam no constrangimento, na perseguição e na ameaça ao professor, suscitando, assim, a construção de práticas não negociáveis no âmbito de uma sociedade alicerçada nos princípios da justiça e da democracia
Kantian Constructivism and Practical Reasoning in Clinical Bioethics
Authors: Morelli Jacopo
Published: May 2023

Philosophers are often accused of constructing theoretical systems that are disconnected from real problems, detached from concrete issues, and sheltered in their _Turris eburnea. _This is a criticism that needs to be explicitly addressed, especially by moral philosophers. In this paper I set out to show how the metaethical and normative debate can reconnect with applied ethics: I will argue that moral constructivism can relate to empirical evidence in some areas, such as the biomedical field, to adapt their normative claims accordingly.

        Firstly, after briefly introducing and defining the field of practical reasoning, I will show what moral constructivism is and what it can do in practice to face moral dilemmas. Secondly, I will argue that in the biomedical field it is possible to have behaviors, both on the part of patients and health professionals, that can be addressed as practically irrational, and I will also show which tools we can use to counter this irrationality[1]. However, the objective of this paper does not stop here and wants to propose not only blocking strategies for irrational demands, but also proactive proposals for cures, implementing the proposal of Kantian constructivism with Viafora's proposal centered on respecting the dignity of the patient as a person.

        Finally, I will argue that the set of principles we can draw from the various cases, while serving the important function of guiding us in future situations, do not constitute a complete theory of practical reasoning or ethical theory. What philosophy can do in the field of bioethics is not to provide a definitive list of rules, since the variety and diversity of the contingent cases will always be too wide to fit into overly defined schemes. Philosophy can, however, provide a common language for approaching morally relevant problems and for enabling agents to grasp the moral significance of concrete situations with the right tools.
“O tratamento da sífilis nos homens à luz da enfermagem transcultural”
Authors: Veiga Maria Beatriz de Assis , Silva Leila Rangel da
Published: May 2023

A sífilis é uma infecção bacteriana que acomete todas as classes sociais, que causa comprometimento sua saúde de homens e mulheres, prejudicando inclusive o exercício da sexualidade. No que tange ao público masculino, sabe-se que fatores sociais e culturais implicam negativamente no seu autocuidado, e na dificuldade em buscar os serviços de saúde. Os profissionais de enfermagem podem desempenhar papel fundamental nas estratégias voltadas à prevenção, diagnóstico e tratamento da sífilis. Objetivo Identificar os fatores culturais e sociais relacionados ao tratamento da sífilis nos homens à luz da Teoria da Diversidade e Universalidade do Cuidado Cultural. Métodos Estudo qualitativo e descritivo, realizado entre 2017 e 2018, no Rio de Janeiro/ Brasil, com 32 homens diagnosticados com sífilis. A narrativa de vida e a análise temática foram utilizadas para a coleta e tratamento dos dados, respectivamente. Resultados A maioria dos homens (71,8%) eram pretos/pardos, homossexuais (50,0%), com histórico de outras Infecções Sexualmente Transmissíveis (78,1%), e foram tratados com penicilina benzatina (90,6%). A dificuldade de acesso e organização inadequada dos serviços de saúde, o desabastecimento de penicilina benzatina e o medo associado à sua administração foram apresentados como principais fatores de impacto negativo para o tratamento. Em contrapartida, a organização dos serviços de saúde faz-se necessária para facilitar o acesso ao tratamento, assim como o acolhimento e vínculo com os profissionais de saúde que acompanham o tratamento, principalmente a equipe de enfermagem, favoreceram a continuidade do mesmo. Considerações finais Tratar a sífilis nos homens requer mais do que a prescrição e administração medicamentosa, necessita de envolvimento e de cuidado integral construído junto aos usuários.