bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of Some Fertility and Growth Traits of Akkaraman Sheep under Breeder Condition in Altunhisar District of Niğde Province
Authors: Duman Mustafa , Şekeroğlu Ahmet , Aksoy Yüksel
Published: June 2024

The aim of this study was to determine some reproductive and growth characteristics and was to analyses some environmental factors the growth and survival performance of lambs between 2017 and 2020 reared within the framework of the National Small Ruminant Project in Altunhisar district of Nigde. The data of the study were collected from 24000 heads ewes and 24869 male and female lambs raised in 25 different farms. The average of infertility, fertility, fecundity, litter size, single and twining rates of Akkaraman ewes were found to be 7.90, 92.10, 1.04, 1.13, 87.49 and 12.51%, respectively. The effects of year of birth, type of birth, age of dam and gender on birth, 60th day and 120th day live weights of Akkaraman lambs were found to be statistically significant (P<0.001). It was also determined that the effect of type of lambing, gender, year of birth and dams age on the survival of lambs at 60th and 120th days was significant (P<0.01). The average survival rate of lambs at 60th and 120th day was 96.2 and 95.3.%, respectively. As a result, it was concluded that while the reproductive characteristics of Akkaraman ewes were in accordance with the literature reports, the effects of the environmental factors on the live weights and survival of lambs were significant and these factors were partially affected by slower growth.
Sustainable Energy Practices in Cabbage Production in Niğde Province of Türkiye
Authors: Kizildeniz Tefide , Kilit Melek Nur
Published: June 2024

Examining the inputs to agricultural production and analyzing their energy implications is a crucial method for assessing environmental challenges and promoting sustainability. The agricultural industry utilizes energy in diverse ways, both directly and indirectly, encompassing pesticides, electricity, fertilizers, farm equipment, irrigation systems, fuel, and human labor. This research focused on assessing the agricultural inputs utilized in cabbage cultivation within one of the most cabbage cultivated area in Türkiye, gathering data on these inputs, and identifying the energy efficiency associated with this production process. In the study, information on the overall energy inputs was gathered from numerous white cabbage producers in the Niğde province using the face-to-face survey method, a quantitative research approach. According to the results of the research, the total energy input equivalent in cabbage production was determined as 4407.87 MJ da-1 and the total output value was determined as 6348.60 MJ da-1. The energy productivity was determined as 1.20 and the energy balance as 1940.73 MJ da-1. According to the findings, with 33.4% of diesel oil, 23.81% of fertilizer, and 23.06% of machinery make up the majority of this production's inputs. Also, 89.19% of the total energy inputs in cabbage production determined as non-renewable and 10.79% of them as renewable energy inputs. In conclusion, the inputs are efficiently utilized in cabbage production within the Niğde province of Türkiye.
Reconfiguración de la vida cotidiana durante la pandemia por Covid-19
Authors: Kuri Pineda Edith
Published: June 2024

En este artículo se analiza sociológicamente quiebres y ajustes de la vida cotidiana durante la etapa de confinamiento por Covid-19 en la Ciudad de México, así como modificaciones ocurridas en las relaciones sociales, con base en dieciséis entrevistas a profundidad hechas a hombres y mujeres en edad productiva e insertos en la economía formal, con el objeto de recabar cambios registrados en los principales dominios de la vida cotidiana —trabajo y hogar— y, con ellos, posibles transformaciones en las interacciones, prácticas y rutinas, además de significados atribuidos a la experiencia de la pandemia.
El trabajo es producto de una investigación empírica cualitativa que parte de un conjunto de preceptos teóricos de la tradición fenomenológica, en particular de la óptica analítica de autores como Alfred Schutz, Anthony Giddens y Alicia Lindón. Como se expone, la vida cotidiana constituye una dimensión seminal estructurada socialmente, que a la vez estructura el quehacer humano, articulado espaciotemporalmente y cuya institucionalización no excluye dinámicas de creatividad e innovación y representa una esfera vital de reproducción de la sociedad donde se erigen emociones medulares como la certeza y la confianza, conculcadas durante la pandemia.
Palabras clave: Pandemia, Covid-19, Vida cotidiana, Relaciones sociales, Rutinas
Afectación de la minería ilegal a los Objetivos de Desarrollo Sostenible en Colombia
Authors: Rodríguez-Morales Tania Gabriela
Published: June 2024

Este capítulo analiza la actual situación de deterioro medioambiental causada por la extracción ilícita de yacimientos mineros (EIYM) en el Departamento de Chocó; diagnos-tica las condiciones de las comunidades ribereñas del río Atrato y el impacto del delito ma-teria de esta investigación en los ODS; resalta el trabajo de las Fuerzas Militares que, con dichas comunidades, vela por la protección del medioambiente en la zona, y explica que, aunque la EIYM puede ser vista como una forma de subsistencia, no debe confundirse con la minería artesanal que históricamente han ejercido las comunidades afrocolombianas de las poblaciones ribereñas.
Energy management strategy of microgrid based on photovoltaic and energy storage system in construction area of Sichuan-Tibet Railway
Authors: Shu Na , Jiang Shan , Fan Zhongze , Cao Xiaoman , Zhang Zeling
Published: June 2024

The construction area of the Sichuan-Tibet Railway is located at a high altitude with thin air conditions, but it benefits from excellent solar irradiance. To address issues such as insufficient power and low efficiency of traditional fuel-based equipment in such harsh environments, electric equipment is being employed as a replacement for conventional fuel-based equipment. In order to achieve sustainable development for the Sichuan-Tibet Railway, this article proposes that a microgrid can be conducted in the construction area of the Sichuan-Tibet Railway which will provide power to the electric equipment during the construction process and to electric locomotives upon completion. This article compares the characteristics of AC microgrids and DC microgrids, analyses and simulates the mathematical model of key converters, and introduces their control strategies. This article adopts a hybrid AC-DC microgrid for research purposes and proposes a time-period-controlled energy management strategy for the photovoltaic-storage hybrid AC-DC microgrid in the construction area of the Sichuan-Tibet Railway. The simulation results demonstrate that the AC-DC microgrid in the construction area based on the proposed time-period-controlled energy management strategy could effectively meet the load demands of different time periods and provide power to the electric equipment used in the construction area of the Sichuan-Tibet Railway.
Bibliometric Analysis of Performance Management: Research Obstacles and Opportunities
Authors: Hanifa Muhammad , Widagdo Bambang , Kurniawan Robert
Published: June 2024

This study presents a bibliometric analysis of publications relevant to performance management. Increased research in management has led to the emergence of a new paradigm in applying performance management systems. The researchers explore how to improve the effectiveness of the performance of companies and institutions. This bibliometric analysis research found 945 articles related to performance management using the Scopus database. The R-Studio bibliometric package is used to conduct data analysis to find trends, worldwide distribution of documents, influential journals, frequently used citations, and countries that dominate publishing articles. This study aimed to analyze articles from the Scopus database related to "Performance Management." The findings obtained in this study that the effectiveness of management lies in the organization's ability to determine goals, motivate employees to change individual behavior, and use the Balanced Score Card (BSC). This research can assist organizations in improving the effectiveness of performance management and as an illustration for future research.
ANALISIS SWOT DAN PEMASARAN DIGITAL STRATEGI PENINGKATAN BISNIS UMKM KREMESAN AYAM CSP SNACK
Authors: Dewa Chriswardana Bayu , Safitri Lina Ayu , Hadi Wisnu
Published: June 2024

Abstrak: Tujuan penelitian ini adalah menganalisis mengenai strategi peningkatan bisnis pada UMKM Kremesan Ayam CSP Snack yang beralamat di Jalan Candiwinangun No.7, Sardonoharjo, Ngaglik Sleman, Yogyakarta. Objek penelitian ini berupa strategi peningkatan bisnis dengan melakukan analisis SWOT dan pemasaran digital. Selain analisis SWOT, peneliti juga melakukan analisa pemasaran digital untuk mengetahui keefektifan dan efesiensi pemasaran digital yang dilakukan oleh UMKM terhadap peningkatan penjualan. Jenis data yang digunakan adalah data primer, dengan melakukan wawancara kepada UMKM Kremesan Ayam CSP Snack. Metode pengumpulan data pada penelitian ini adalah observasi, wawancara, kuesioner dan studi literatur. Analisis data menggunakan analisis SWOT dengan melakukan perhitungan pada IFAS (Internal Factors Analysis Strategic) dan EFAS (Eksternal Factors Analysis Strategic). Hasil pada penelitian ini dapat disimpulkan berdasarkan hasil analisis SWOT ditemukan posisi UMKM Kremesan Ayam CSP Snack berada di kuadran satu dimana UMKM Kremesan Ayam CSP Snack sedang dalam kondisi bisnis progresif. Kondisi bisnis progresif berarti UMKM Kremesan Ayam CSP Snack sedang dalam kondisi menguntungkan karena mengalami peningkatan jumlah permintaan. Hal tersebut mengakibatkan meningkatkan kepercayaan konsumen akan keamanan produk dari segi kualitas makanan. Strategi yang diterapkan pada kondisi bisnis progresif adalah mendukung kebijakan pertumbuhan yang agresif (Growth Oriented Strategy).

Kata Kunci: Analisis SWOT, Pemasaran Digital, Strategi Bisnis, UMKM
ANALISIS RISIKO KEUANGAN DAN PROFITABILITAS EMITEN SEKTOR KESEHATAN DI BEI
Authors: Aminah Aam , Ambardi Ambardi
Published: June 2024

Dalam setiap aktivitas bisnis selalu ada risiko. Salah satu risiko yang dihadapi perusahaan adalah risiko keuangan. Risiko keuangan adalah segala bentuk keputusan yang berkaitan dengan keuangan yang menimbulkan kerugian. Tujuan penelitian ini adalah untuk menganalisis risiko perusahaan dari sisi risiko keuangan dan pengaruhnya terhadap profitabilitas emiten Kesehatan di BEI. Metode penelitian ini adalah dengan menggunakan model regresi data panel. Populasi penelitian ini adalah  emiten  sektor kesehatan  yang terdaftar di bursa efek Indonesia. Kriteria yang dipilih dalam penentuan sampel adalah Emiten sektor kesehatan yang terdaftar di BEI sejak tahun 2019-2022, Emiten menyampaikan laporan keuangan 31 desember secara rutin selama  4 tahun. Variabel  independen dalam penelitian ini adalah Current Rasio (X1), Debt to Asset Ratio (X2). Variabel dependen yang digunakan dalam peneitian ini adalah Return On Asset (Y). Dalam peneltian ini dilakukan pengujian pemilihan model terlebih dahulu  dengan menggunakan uji chow dan uji Hausman. Chow Test dilakukan untuk membandingkan model mana yang terbaik antara Common Effect Model (CEM) dan Fixed Effect Model (FEM). Hasil temuan penelitian ini adalah Variabel liquiditas (CR) tidak berpengaruh secara signifikan terhadap profitabilitas (ROA) emiten sektor kesehatan.di bursa efek Indonesia dan Variabel solvabilitas (DAR) juga tidak berpengaruh secara signifikan terhadap ROA pada emiten sektor kesehatan di bursa efek indonesia.

 

Kata Kunci :  Risiko keuangan, Profitabilitas, Sektor Kesehatan
PENGARUH GREEN MARKETING, BRAND IMAGE, DAN BRAND EQUITY TERHADAP KEPUTUSAN PEMBELIAN PRODUK THE BODY SHOP DI YOGYAKARTA
Authors: Adiyantie Imada Intan
Published: June 2024

Penelitian ini bertujuan untuk menganalisis pengaruh Green Marketing, Brand Image dan Brand Equity terhadap Keputusan Pembelian pada produk The Body Shop di Yogyakarta. Sampel dalam penelitian ini berjumlah 100 responden yang pernah melakukan pembelian produk The Body Shop. Teknik pengumpulan data yang digunakan adalah metode survei dengan instrumen penelitian ynag digunakan adalah kuesioner. Hasil uji instrument menunjukkan bahwa semua data dinyatakan valid dan reliabel. Hasil uji asumasi klasik menunjukkan bahwa data berdistribusi normal dan menghasilkan model regresi yang bebas dari multikolonieritas dan heteroskedastisitas. Hasil penelitian ini membuktikan bahwa:Green Marketing(X1), Brand Image(X2), dan Brand Equity(X3) berpengaruh positif dan signifikan terhadap Keputusan Pembelian (Y). Hasil penelitian ini membawa implikasi untuk mendukung kajian pustaka sebelumnya yang menyatakan bahwa keputusan pembelian dipengaruhi oleh  green marketing, brand image dan brand equity. Hasil penelitian ini membawa implikasi bagi perusahaan The Body Shop dalam merancang strategi pemasaran yang dapat dilakukan dengan cara memperkuat green marketing , brand image, dan brand equity, guna meningkatkan keputusan pembelian yang tinggi. 
FINANCIAL KNOWLEDGE, FINANCIAL ATITUDE DAN FINANCIAL MANAGEMENT BEHAVIOR MAHASISWA FEB UNIPA SETELAH PANDEMI COVID-19
Authors: Estiasih Soffia Pudji , Suhardiyah Martha , Kurniawan Widiar Onny , Rahmadhani Liviana Dwi , Wardani Danisa Firda Kusuma
Published: June 2024

Financial Knowledge adalah kemampuan untuk memahami, menganalisis, mengelola keuangan untuk membuat keputusan keuangan. Sedangkan Financial Attitude merupakan sebuah perilaku untuk mengelola dan menggunakan keuangan yang dimiliki untuk mencapai tujuan dari penggunaan keuangan. Tujuan dari penelitian ini untuk mengetahui dan menganalisis Financial Knowledge, Financial Attitude dan Financial Management Behavior pada Mahasiswa FEB UNIPA Setelah Pandemi Covid-19, karena sebagian dari mahasiswa beban hidupnya masih ditanggung oleh orang tua terutama mahasiswa yang tidak tinggal bersama orang tua, setiap bulannya mahasiswa masih mengandalkan kiriman orang tua untuk memenuhi keperluannya selama kuliah.  Agar kondisi keuangan mahasiswa tetap terjaga sampai lulus maka perlu adanya pengetahuan keuangan dan sikap keuangan serta perilaku mananajemen terkait pembiayaan perkuliahan. Populasi dalam penelitian ini adalah seluruh mahasiswa FEB (Prodi akuntansi dan Prodi Manajemen) dan sampel yang dipergunakan sebesar 80 mahasiswa dengan teknik pengambilan 5 kali jumlah indikator. Teknik analisis menggunakan Regresi Linier Berganda Hasil penelitian ini menunjukkan bahwa secara parsial  Financial Knowledge, Financial Attitude berpengaruh signifikan terhadap Financial Management Behavior pada Mahasiswa FEB UNIPA Setelah Pandemi Covid-19.
PENGARUH KUALITAS PRODUK DAN BRAND AWARENESS TERHADAP KEPUTUSAN PEMBELIAN ULANG MELALUI KEPUASAN PELANGGAN
Authors: Hendri Alwan , Ruspitasari Widi Dewi , Bukhori Mohammad
Published: June 2024

One of the typical foods of the Riau region is Ketan talam durian which was introduced by Rumah Kue Viera which is very delicious, its development is extraordinary.. The purpose of this research is to find out and analyze 1) the effect of product quality on Repurchase Decision 2) the effect of Brand Awereness on Repurchase Decision, 3) the effect of product quality on customer satisfaction, 4) the effect of Brand Awereness on customer satisfaction,5) the effect of customer satisfaction on Repurchase Decision, 6) the effect of product quality on Repurchase Decision through customer satisfaction, 7) the effect of Brand Awereness on Repurchase Decision through customer satisfaction. This study uses a quantitative descriptive approach to Viera Cake House customers. The research population is Viera Cake House customers who have shopped more than once in Mey 2023 with a research sample of 100 respondents using an accidental sampling technique. The inferential statistical analysis technique uses the Partial Least Square (PLS) technique with the SmartPLS 4.0 tool. The test instruments used are validity and reliability tests, outer model construction tests, discriminant validity tests with the Fornell-Larckel Criterion and the AVE method, Inner Model R-Square, Q-Square and GoF tests, Bootstrapping hypothesis testing,, the results show 1) product quality affects customer satisfaction 2) Brand Awareness affects customer satisfaction 3) product quality affects repurchase decisions, 4) Brand Awareness affects repeat purchase decisions, 5) customer satisfaction does not have a significant effect on repurchase decisions 6) product quality does not affect repurchase decisions through customer satisfaction 7) Brand Awareness does not affect repurchase decisions through customer satisfaction.
Profil de la péricardite en dialyse péritonéale : à propos de 5 cas
Authors: Darbal Kaoutar , EL Maakoul Sara , Ouzzedoun Naima , Benamar Loubna
Published: June 2024

Les complications cardiovasculaires sont fréquentes chez les patients sous dialyse péritonéale, parmi lesquelles les péricardites aiguës constituent une manifestation rare. Un diagnostic et une prise en charge précoces et appropriés des péricardites aigues sont cruciaux pour prévenir les complications graves telles que la tamponnade cardiaque. Bien que les traitements anti-inflammatoires soient souvent efficaces, une attention particulière doit être portée aux effets indésirables, en particulier chez les patients présentant une insuffisance rénale. Des études supplémentaires sont nécessaires pour mieux comprendre les mécanismes sous-jacents et optimiser les stratégies thérapeutiques pour cette population de patients. Nous allons présenter à partir de cet article cinq cas cliniques de péricardites aiguës parmi 239 patients en dialyse péritonéale.
Module infirmier du Registre de Dialyse Péritonéale de Langue Française. Rapport 2022-2023.
Authors: Veniez Ghislaine , Durand Pierre Yves , Fabre Emmanuel , Verger Christian
Published: June 2024

La base de données du registre de dialyse péritonéale de langue française (RDPLF) est constituée de plusieurs modules spécialisés et interconnectés. Depuis 1980, les centres du RDPLF ont enregistré les principaux aspects de la formation infirmière, pour plus de 16.000 patients, dans un module infirmier destiné aux équipes soignantes. Nous rapportons une analyse descriptive des informations incluses dans le module infirmier du RDPLF sur les deux années 2022 et 2023, afin d’éviter le biais qui aurait pu être présent pendant la période de pandémie de SRAS Cov2 qui a précédé. Afin d’avoir une population homogène, nous n’avons inclus que des patients de France métropolitaine. L’âge moyen des patients était de 69,5±16 ans. Il était plus élevé en dialyse péritonéale continue ambulatoire (69,7 ans) qu’en dialyse péritonéale automatisée (DPA) (57,8 ans). Les patients autonomes représentaient 60% de la population étudiée. La majorité des patients savaient adapter leurs fluides à leur état clinique. Une modification des informations enregistrées dans le module sera nécessaire pour l’adapter aux outils de formation modernes.
Assembly line library synthesis in flow: A multistep and multivectorial approach
Authors: Pijper Brenda , Abdiaj Irini , Mazuela Javier , Linares Maria Lourdes , Gomez Jose Enrique , Rodriguez Raquel , Chaves Arquero Belén , Palao Eduardo , Cañellas Santiago , Alcazar Jesus
Published: June 2024

In drug discovery, traditional automated library synthesis has typically involved single-step synthetic procedures targeting a single vector of interest. However, achieving greater structural diversity requires exploring multistep and multivectorial approaches. These methodologies enable the preparation of compounds with varying structures in a single experiment. Here, we present a novel method for multistep library synthesis in continuous flow. This approach offers unique opportunities, such as exploring linkers between two defined vectors or rapidly mapping synergistic structure-activity relationship (SAR) by concurrently exploring multiple vectors. Our method incorporates up to eight different synthetic methodologies, including established chemistries, metal-catalysed transformations, and modern metallaphotoredox couplings. This broad range of synthetic methodologies ensures a high level of diversity in the compounds generated, providing a powerful tool to accelerate exploration of the chemical space in drug discovery programs.
Assessment of Available Energy Resources in Louisiana, United States for Sustainable Energy Mix Design
Authors: Edor Godwin
Published: June 2024

As the world's population grows, industrial, agricultural, transportation and other energy-intensive activities increase exponentially, leading to high energy demands. However, overreliance on fossil fuels as a primary energy source has posed a significant threat to the planet and its habitats because of high GHG emissions into the atmosphere, resulting in an unstable climate change. To mitigate this challenge, there is a need to balance energy demand with sustainability and social, economic, and environmental impacts associated with energy usage. Unfortunately, depends excessively on non-sustainable forms of energy to meet its high energy demands with only 3.5% of its utility-scale electricity generated from renewable energy resources, despite being blessed with an abundance of sustainable energy resources. This project conducted a feasibility study on the energy resources available in Louisiana for different energy indicators, aiming at designing an energy portfolio that is sustainable, reliable, affordable, versatile, and meets state's high-energy demand. Based on the results obtained, a sustainable energy mix comprising 63% natural gas, less than 6% coal, 14% nuclear, 2% hydroelectric, 6% solar, 4% biomass, and 5% wind was proposed for Louisiana's net utility-scale electricity production to help achieve minimal net emissions by 2035. Energy policies that can be implemented to catalyze the transition have also been suggested.
Alkali cation stabilization of defects in 2D MXenes at ambient and elevated temperatures
Authors: Wyatt Brian , Boebinger Matthew , Hood Zachary , Adhikari Shiba , Michałowski Paweł , Nemani S. Kartik , Gopal Muraleedharan Murali , Bedford Annabelle , Highland Wyatt , Kent Paul , Unocic Raymond , Anasori Babak
Published: June 2024

Transition metal carbides have been adopted in energy storage, conversion, and extreme environment applications. Advancement in their 2D counterparts, known as MXenes, enables the design of unique structures at the ~1 nm thickness scale. Alkali cations have been essential in MXenes manufacturing processing, storage, and applications, however, exact interactions of these cations with MXenes are not fully understood. In this study, using Ti3C2Tx, Mo2TiC2Tx, and Mo2Ti2C3Tx MXenes, we present how transition metal vacancy sites are occupied by alkali cations, and their effect on MXene structure stabilization to control MXene’s phase transition. We examine this behavior using in situ high-temperature x-ray diffraction and scanning transmission electron microscopy, ex situ techniques such as atomic-layer resolution secondary ion mass spectrometry, and density functional theory simulations. In MXenes, this represents an advance in fundamentals of cation interactions on their 2D basal planes for MXenes stabilizations and applications. Broadly, this study demonstrates a potential new tool for ideal phase-property relationships of ceramics at the atomic scale.
In-silico studies of anti-tuberculosis drugs using advanced computational techniques
Authors: Pandey Anwesh , Panthi Bhavana , Kumar Suresh
Published: June 2024

As per the 2022 global tuberculosis (TB) report, TB ranked among the top ten causes of mortality worldwide, surpassing both HIV and malaria in fatalities. It is a communicable disease induced by the Mycobacterium tuberculosis (MTB). Herein the role of molecular modeling tools in the search for new TB therapeutics involves quantitative structure-activity relationship (QSAR), pharmacophore modeling, and molecular docking. In the present work, we compiled approximately 1000 anti-TB candidates from the literature, along with their experimentally determined activities, and classified into three classes based on their biological activities, viz.,pIC, pIC_50, and pMIC_50. All selected compounds were optimized followed by docking them to anti-TB receptors retrieved from the Protein Data Bank. The docking results delineate the nature of interactions between the ligands and their respective receptors, which are prevalently noncovalent, dominated by hydrogen bonds and van der Waals’ interactions. Additionally, DFT-based descriptors were calculated such as constitutional, geometrical, topological, quantum chemical and docking based descriptors basis on their biological activities. The best models were selected on the basis of statistical parameters and were validated by training and test set division.
Heterologous Biosynthesis of Cotylenol and Concise Synthesis of Fusicoccane Diterpenoids
Authors: Guan Zhenhua , Yuan Ye , Zhang Xue-Jie , Yao Nanyu , Yuan Wenling , Zhang Yonghui , Ye Ying , Xiang Zheng
Published: June 2024

Fusicoccane diterpenoids have attracted intensive attention due to their complex structures as well as diverse biological activities. Here we report a novel strategy for the synthesis of cotylenol and other fusicoccane diterpenoids. By harnessing the biosynthetic pathways of brassicicenes and fusicoccins, cotylenol was produced in an engineered Aspergillus oryzae strain. We further achieved the concise synthesis of three fusicoccane diterpenoids, including alterbrassicicene E and brassicicenes A and R in 4 or 5 chemical steps from brassicicene I. Our strategy may facilitate the preparation of fusicoccane diterpenoids and their synthetic analogues for biological studies.
2,2-Difluoroethylation of heteroatom nucleophiles via a hypervalent iodine strategy
Authors: Das Suman , McIvor Charlotte , Greener Andrew , Suwita Charlotte , Argent Stephen , O'Duill Miriam
Published: June 2024

The 2,2-difluoroethyl group is an important lipophilic hydrogen bond donor in medicinal chemistry, but its incorporation into small molecules is often challenging. Herein, we demonstrate electrophilic 2,2 difluoroethylation of thiol, amine and alcohol nucleophiles with a hypervalent iodine reagent, (2,2-difluoro-ethyl)(aryl)iodonium triflate, via a proposed ligand coupling mechanism. This transformation offers a complementary strategy to existing 2,2-difluoroethylation methods and allows access to a wide range of 2,2-difluoroethylated nucleophiles, including the drugs Captopril, Normorphine and Mefloquine.
Sickle Cell Hemoglobin Drugged with Cyclic Peptides is Aggregation Incompetent
Authors: Galamba Nuno
Published: June 2024

Sickle cell disease is a monogenic blood disorder associated with a mutation in the HBB gene encoding for the β-globin of normal adult hemoglobin (HbA). This mutation transcribes into a Gluβ6→Val-β6 substitution in the β-globins, inducing the polymerization of this hemoglobin form (HbS) when in the T-state. Despite advances in stem cell and gene therapy and the recent approval of a new anti-sickling drug, therapeutic limitations persist. Herein, we demonstrate through molecular dynamics and umbrella sampling, that (unrestrained) blockage of the hydrophobic pocket involved in the lateral contact of the HbS fibers by 5-mer cyclic peptides (CPs) recently proposed as SCD aggregation inhibitors (J. Med. Chem. 2023, 66, 16062), is enough to turn the dimerization of HbS thermodynamically unfavorable. Amongst these potential drugs, some exhibit an estimated pocket abandonment probability of around 15-20% within the simulations’ timeframe, and an impressive specificity towards the mutated Val-β6. Additionally, we show that the dimerization can be thermodynamically unfavored by blocking a nearby region while the pocket remains undrugged. These results are compared with curcumin, an antisickling molecule and a pan-assay interference compound, with a good binding affinity for different proteins and protein domains. Our results confirm the potential of some of these CPs as anti-sickling drugs to reduce the concentration of aggregation-competent HbS.
Transmission of 10 Gbps C-band-signal-based Radio Over Fiber for Next Generation Communication Systems
Authors: Al Deen Hasan k. , Abd Haider J.
Published: June 2024

Rapid development of 5G networks encourages researchers to improve the radio-over-fiber (RoF) technique in order to reach 10 Gbps data transmission rates, to increase bandwidth and range, while reducing latency and implementation cost. This paper evaluates an analog radio-over-fiber (ARoF) technique that is compatible with long-distance communication systems. We demonstrate a long distance transmission of a 28 GHz 64 QAM signal via a single mode fiber (SMF) after modulating it with the use of two parallel Mach-Zehnder modulators, without any optical amplifiers. The results show that our prototype solution is capable of transferring data over distances of up to 140 km, via SMF, with a 10 Gbps data rate. The error vector magnitude (EVM) was found to be 7.709%. The proposed system offers exceptional capabilities in terms of supporting high bitrates, while ensuring that EVM remains within the 3GPP limits. Compared to other works, the proposed solution proves to be superior in terms of performance, making it an ideal choice for next generation long-haul communication systems.
Analysis and Prediction of Rainfall with Oceanic Nino Index and Climate Variables Using Correlation Coefficient and Deep Learning
Authors: Buathongkhue Chayanat , Sureeya Kritsana , Kaewthong Natapon
Published: June 2024

This article presents the relationship between the Oceanic Nino Index (ONI) and monthly rainfall on the southern and eastern coast of Thailand, specifically in Narathiwat, Pattani, and Yala provinces, where influences have been commonly observed. This research aims to study the relationship between the Oceanic Nino Index (ONI) and monthly rainfall to develop a model for predicting monthly rainfall. Despite previous related research, there has been no in-depth study on the relationship between the Oceanic Nino Index (ONI) and monthly rainfall in areas adjacent to the sea. The correlation coefficient was used to determine the relationship, revealing that the ONI value is significantly correlated with the amount of rainfall in the current month and the following month. This correlation paved the way for developing a model to predict monthly rainfall. Multiple linear regression, recurrent neural networks, and long short-term memory models were employed for this purpose. The study found that utilizing a recurrent neural network yielded the best prediction efficiency, with Mean Absolute Error (MAE) values of 112.76 mm for Narathiwat province, 81.06 mm for Pattani province, and 97.67 mm for Yala province. Doi: 10.28991/CEJ-2024-010-05-01 Full Text: PDF
Quality of Harvested Rainwater from a Green and a Bitumen Roof in an Air Polluted Region
Authors: Tsanov Emil , Valchev Dobril , Ribarova Irina , Dimova Galina
Published: June 2024

A one-year study was conducted to evaluate the impact of air pollution and roof coating on runoff quality. An existing 440 sq meter bitumen roof of a single-story building was coated with an extensive green roof layer on one half. Rainfall and runoff samples from both roofs were collected during 11 rainfall events after the separation of the first flush. The study monitored several key parameters, including pH, electrical conductivity (EC), turbidity, chemical oxygen demand (COD), ammonium nitrogen, nitrate nitrogen, and phosphates. The study revealed that both types of roofs altered the rainfall quality, but the changes caused by the green roof were more substantial. Although the retention of runoff from green roofs has a widely acknowledged positive impact on collecting systems, our study shows that green roofs also result in a 7.5-fold increase in COD concentrations, a 5.4-fold increase in the sum of ammonium and nitrate nitrogen, and a 2.3-fold increase in phosphates compared to bitumen roofs. A clear link between the quality of rainwater/runoff and air pollution was not established. The study's findings will aid in the development and management of local rainwater harvesting systems and enhance global understanding of the primary quality parameters of various roof types, particularly in regions with air pollution. Doi: 10.28991/CEJ-2024-010-05-015 Full Text: PDF
GGBFS and Red-Mud based Alkali-Activated Concrete Beams: Flexural, Shear and Pull-Out Test Behavior
Authors: Al-Jabali Hebah M. , El-Latief Ahmed A. , Ezz Mohamed Salah , Khairy Shady , Nada Amr A.
Published: June 2024

Geopolymers and antacid-enacted fasteners have accumulated critical interest as promising development and fixing materials because of their exceptional properties. Also, they bring about less contamination contrasted with regular concrete cements. Geopolymers address a clever class of suggested restricting materials blended through the basic enactment of bountiful aluminosilicate materials. The usage of geopolymer materials from side effects offers a critical decrease in carbon impression and yields positive natural effects. Geopolymer is progressively recognized as a plausible substitute for OPC concrete. In this review, sodium-based antacid activators, especially sodium metasilicate (Na2SiO3), were used for different blend extents. The boundaries researched included NaOH arrangements with a grouping of 8 M, alongside a Na2SiO3/NaOH proportion of 1. This paper evaluates the fundamental characteristics of geopolymer cement beams, employing red mud and GGBFS in powdered form as complete replacements for traditional concrete. Six bar specimens are tested under a two-point static loading condition, all cured at room temperature under ambient conditions. Of the six beams, three were exposed to flexural conduct testing with a molarity of 8 M, while the excess three beams were tried for shear conduct. The outcomes of testing geopolymer beams subjected to shear and bending loads indicated that the beams incorporating aluminum slag performed better than those incorporating blast furnace slag. Both types also demonstrated promising results compared to beams incorporating OPC, highlighting their potential environmental benefits compared to cement use. Doi: 10.28991/CEJ-2024-010-05-09 Full Text: PDF
La Investigación Social en México, 2013. Tomo I
Authors: Ortiz Lazcano Asael
Published: June 2024

La estructura familiar y social ha sufrido una transformación radical en las últimas décadas, que sumado a la incorporación de la mujer al mercado laboral, el descenso de la fecundidad y las recurrentes dificultades económicas, no solo se ha constreñido la economía, además la familia y la sociedad se ha reconfigurado, y no necesariamente para mejorar el nivel de bienestar, por el contrario, para ver disminuida en mayor medida su situación económica y laboral.
Anatomía seno esfenoidal y diámetros de la fosa hipofisaria en adultos en tomografía de cráneo.
Authors: Segura Mestanza José Homero , Molina Miranda Elsa Cecilia
Published: June 2024

El avance tecnológico de las pruebas de imagen ha permitido la valoración morfológica exacta de las variantes anatómicas de las estructuras que se encuentran en el interior del cráneo, seno esfenoidal y fosa hipofisaria, que es útil para la planeación de las intervenciones quirúrgicas transesfenoidal o estructuras adyacentes. El presente estudio tiene como objetivo determinar la morfometría y dimensiones mediante tomografía computarizada del seno esfenoidal y fosa hipofisaria. Se realizó de manera retrospectiva la búsqueda de pacientes adultos  sin patologías adyacentes que cuenten con tomografía de cráneo en el Hospital de Especialidades Fuerzas Armadas N “1”, durante el periodo enero diciembre 2020, que cumplían con los criterios de inclusión, exclusión, obteniendo un total de 312 imágenes, se analizó la morfometría y dimensiones del seno esfenoidal y la fosa hipofisaria, mediante frecuencia absoluta, relativa y pruebas chi-cuadrado, el nivel de significación estadística p<0.05. Los resultados obtenidos nos demuestran que no existe significancia estadística ni correlación entre las variables de dimensión y volumen del seno esfenoidal y silla turca. De igual manera no existe una relación de estas variables con el sexo y rango de edad. El tipo de neumatización del seno esfenoidal no está asociada al sexo y la edad de los pacientes. La forma de la silla turca tiene relación con el sexo de los participantes. La relación entre el volumen del seno esfenoidal y volumen de la silla turca valores no presentó significancia estadística, y presentó una correlació Spearman baja.
The Importance of Early Physical Therapy Intervention in Fighting Post-surgical Sequelae in a Patient with Cerebral Abscess
Authors: Adina Camelia Şlicaru , Tatiana Balint , Alina-Mihaela Cristuță
Published: June 2024

The primary objective of this research was to highlight the importance of early physical therapy intervention in fighting neurological sequelae following surgical intervention and improving the patient's level of independence in cases of cerebral abscess. The study was based on identifying the degree of neuro-motor impairment immediately after the surgery, followed by establishing a specific physical therapy intervention strategy based on the identified manifestations. The subjects included in the study had a common clinical diagnosis of cerebral abscess and the presence of neurological sequelae post-surgery. The physical therapy approach consisted of neuro-proprioceptive facilitation techniques and methods, considered the most effective in such pathologies. The results obtained from the initial and final evaluations of the patients included in the study and their interpretationhighlighted that the early application of neuro-motor and proprioceptive facilitation techniques allowed achieving favorable results and reaching the proposed objectives.
Elaboración de Madera Plásticaa base de Polipropileno Recicladoy Lirio Acuático (Eichhornia Crassipes) con Modificador Interfacial.
Authors: Sánchez Cárdenas Alan Roberto , Lozano Ramirez Tomas , Morales Zamudio Luisiana , Del Consuelo Gómez de la Fuente María Idalia , Kharissova Oxana
Published: June 2024

El uso de polipropileno reciclado y lirio acuático (Eichhornia Crassipes) como materias primas busca promover la reutilización de residuos para elaborar madera plástica y reducir la demanda de madera natural, contribuyendo asía la conservación del medio ambiente. Además, sepropone el uso de un modificador interfacial como loesel ácido esteárico para mejorar las interacciones en la interface y la adhesión entre las fibras de lirio acuáticoy la matriz de polipropileno (polímero no polar), lo que permitirá obtener un material con mejores propiedades mecánicas, además en apariencia similar a la madera natural, haciéndolo atractivo para diversas aplicaciones en las que la madera esel único material empleado. Esta propuesta comenzó con el diseño de un proceso para la recopilación, procesamientoy tratamiento del lirio acuáticoy del polipropileno reciclado. Se diseñó el dado para la elaboración de tablas de madera plástica, se prepararon compuestosa concentraciones de 5, 10y 25 w°/o de lirio, con y sin modificador interfacial, se determinó su resistenciaa la flexión siendo el compuesto con 10 w°/» con modificador interfacial el que mostró una resistencia mayora la flexión.
Study on Design Method of a Novel Precast Prestressing Composite Frame Based on African Manner
Authors: Pierre Nsengimana Jaen
Published: June 2024

Precast composite structures are new trend in construction technology in China due to their high sustainability and structural performance. As Chinese construction companies enter Africa continuously, the Chinese developed technologies
are increasingly applied in Africa. A novel precast prestressing composite structure, developed in China, is believed to have a good prospect in Africa. In this study, a design method of the novel precast structure based on the
African design system was developed to promote the application in Africa. The structural design systems in Africa and China were compared to help designers know the difference between the two design systems and develop a better
design method for the new precast prestressed composite frame in Africa. It can be found that the basic theory of the two design systems is similar, but the technical design parameters and equations are different. The structural
design method of the novel precast structure was built with African design system. The basic structural design steps based on the limit state method according to Eurocodes were established, and the seismic design process for the
novel precast structure was also developed based on equivalent lateral seismic force method. Some important structural details of the novel frame for earthquakes based on African manner were presented. The developed detailed design
method of the novel structure was applied by designing a four storey novel building structure expected in Huye City at Southern Province of Rwanda. The design results were validated by comparison with results of the novel four
storey building structure constructed in Suzhou, China. It is shown that both design systems provide safe design since all the results are within allowable limit, and the Chinese design method is more economical but the African
design method is more conservative.
GROWTH, PROTEIN EFFICIENCY RATIO AND PROTEIN RETENTION OF G6 TRANSGENIC MUTIARA CATFISH WITH MIXED FEEDING AT DIFFERENT RATIO OF COMMERCIAL FEED AND REBON SHRIMP FLOUR
Authors: Buwono Ibnu Dwi , Grandiosa Roffi , Iskandar Iskandar , Rahmawati Vina
Published: June 2024

Penelitian ini bertujuan untuk mengevaluasi pertumbuhan ikan lele mutiara transgenik G6 menggunakan pencampuran pakan komersil dan tepung udang rebon dengan rasio yang berbeda antar perlakuan. Penelitian ini dilaksanakan pada bulan Mei-Agustus 2023, di Lab. Akuakultur Gd.4 Fakultas Perikanan dan Ilmu Kelautan Universitas Padjadjaran. Penelitian ini menggunakan metode eksperimental Rancangan Acak Lengkap (RAL) dengan empat perlakuan tiga kali ulangan. Perlakuan berupa pakan campuran pakan komersil dan tepung udang rebon dengan rasio 50:50 (A), rasio 65:35 (B) dan rasio 80:20 (C) diberikan pada ikan lele Mutiara transgenic G6 serta perlakuan kontrol (rasio 65:35) diberikan pada ikan lele Sangkuriang (perlakuan B*). Pemeliharaan dilakukan selama 56 hari dengan pemberian pakan tiga kali sehari. Parameter yang diamati meliputi pertumbuhan bobot mutlak (Wg),rasio konversi pakan/feed convertion ratio (FCR), rasio efisiensi protein (PER), serta retensi protein (RP) yang dianalisis menggunakan ANOVA/Analysis of Varience dengan tingkat kepercayaan 95% apabila berbeda nyata dilanjutkan dengan uji Duncan  menggunakan software SigmaPlot 15.0. Hasil penelitian menunjukan penambahan pakan komersil dan tepung udang rebon dengan rasio (80:20) memberikan pengaruh terhadap performa pertumbuhan ditunjukkan oleh peningkatan nilai pertambahan bobot mutlak (687,53 g), FCR (0,64), rasio efisiensi protein (18,7) dan retensi protein (46,43%.) Nilai kualitas air selama pemeliharaan masih dalam batas ditoleransi untuk pertumbuhan ikan lele mutiara transgenik G6.
PERLAKUAN GURU TERHADAP ANAK DISLEKSIA
Authors: Audiari Ni Nyoman Indi Audiari , Witono A. Hari Witono , Setiawan Heri
Published: June 2024

In the world of education there are learning difficulties in the learning process, where the inability of students to accept or respond in the learning process, so the necessary role of teachers in dealing with learning difficulties. Difficulty reading is called dyslexia. Dyslexia is a difficulty in analyzing speech, sounds, and difficult to learn about how to combine letters and words which is generally felt in children at primary school age. This study aims to describe the treatment of teachers of dyslexic children in Class III SDN 34 Cakranegara. This study uses qualitative research methods with a descriptive approach. There is also a source of data in this study obtained through observing and interviewing homeroom teachers Grade III. There are three lines of activities that can be carried out in data analysis, namely data reduction, data presentation, and conclusion. The results of the analysis showed that there are 3 backgrounds of children with dyslexia, with characteristics of children who do not understand the form of writing, teachers provide facilities in the form of books, with image media, and multisensory methods, and always provide motivation to children to be confident.
A ATIVIDADE PROFISSIONAL DO ECONOMISTA E O CAMPO DAS PERÍCIAS JUDICIAIS E EXTRAJUDICIAIS
Authors:   , JESUS MESTRANDA SABRINA SILVA DE
Published: June 2024

O presente trabalho retrata o campo das perícias como sendo uma alternativa para os Economista aplicarem os conhecimentos adquiridos na academia. De fato, como destaca o COFECON, há necessidade de peritos judiciais no mercado para dar celeridade em processos judiciários que envolve a expertise do profissional economista. Os cursos de Economia, inclusive o da UESC, incluem na formação do Economista disciplinas referentes à perícia e isso inspirou também esse trabalho. O referencial teórico está baseado na sociologia econômica institucional assim como na relação Direito e Economia. Em consequência disso, a metodologia adotada para a realização do trabalho foi a pesquisa bibliográfica, monografias da área de economia, documental, sites, artigos jurídicos e científicos, Ex-post-facto. Logo, foram realizadas as descrições dos tipos de peritos e suas funções na perícia judicial econômica e extrajudicial, as formas de atuação, impedimentos e suspeição do cargo, a nomeação, laudo pericial. As teorias do estudo e as leis vigentes: as exigências legais e pertinentes, Código do Processo Civil, Constituição, lei dos peritos e resoluções dos Conselhos. No segundo capítulo se discutiram os aspectos relacionados com a viabilidade e vantagens da atuação do Economista no campo da perícia judicial, mais especificamente a perícia judicial que tem a ver com os cálculos econômico-financeiros. Em suma, com a entrada em vigor do novo Código Civil, em 2016, foi instituído, no mesmo ano, por parte do COFECON e CORECONs o Cadastro Nacional de Peritos em Economia e Finanças o que representa um grande passo na popularização dessa profissão entre os Economistas.
100 Brigas
Authors: Leitão Joilza Rodrigues Cunha , Leitão Alainy Rosado
Published: June 2024

Ao escrevermos nossa história, Alainy e eu, desejamos
compartilhar não apenas os fatos, mas as emoções e lições
que moldaram nossa jornada juntos. Desde o nosso primeiro
encontro, sentimos uma conexão inegável, uma promessa de
cumplicidade e amor que nos acompanhou ao longo de 47
anos de convivência, incluindo 10 anos de namoro e 37 de
casamento.
Tudo começou no ano de 1976... Estudávamos no mesmo
colégio. Ele, um ano mais velho: tinha 14 e eu 13 anos. Duas
crianças que se conheceram e, desde então, estamos juntos até
hoje. Começamos a nos encontrar todos os dias na hora do
lanche para conversarmos. Falávamos de tudo, o tempo passava
que nem víamos. Lembro que nossos encontros eram sempre
regados de muita emoção e foi se transformando no maior
sentimento que existe: o Amor! Começamos a namorar no final
de 1977. Lembro que nosso primeiro beijo foi aqui em Teresina,
na feira dos Municípios. Como na época, morávamos em
Floriano, viemos numa excursão da escola para apresentarmos
nosso grupo de dança que eu fazia parte e era a coreógrafa e o
coral que também fazíamos parte, ele tocava violão e segurava
sozinho, mais de cem vozes. Começamos a namorar!