bluuebunny/crossref_metadata_2025 huggingface dataset:
Rising Trend Predicted for Conditions Linked to Severe Storms
Authors: Stanley Sarah
Published: January 2022

Climate modeling predicts that conditions conducive to severe thunderstorms will arise more often as Earth warms.
Voluntary workplace genomic testing: wellness benefit or Pandora’s box?
Authors: Sanghavi Kunal , Cohn Betty , Prince Anya E. R. , Feero W. Gregory , Ryan Kerry A. , Spector-Bagdady Kayte , Uhlmann Wendy R. , Lee Charles , Roberts J. Scott , Mathews Debra J. H.
Published: January 2022

Consumer interest in genetic and genomic testing is growing rapidly, with more than 26 million Americans having purchased direct-to-consumer genetic testing services. Capitalizing on the increasing comfort of consumers with genetic testing outside the clinical environment, commercial vendors are expanding their customer base by marketing genetic and genomic testing services, including testing for pharmacogenomic and pathogenic variants, to employers for inclusion in workplace wellness programs. We describe the appeal of voluntary workplace genomic testing (wGT) to employers and employees, how the ethical, legal, and social implications literature has approached the issue of genetic testing in the workplace in the past, and outline the relevant legal landscape. Given that we are in the early stages of development of the wGT market, now is the time to identify the critical interests and concerns of employees and employers, so that governance can develop and evolve along with the wGT market, rather than behind it, and be based on data, rather than speculative hopes and fears.
Designing quantum networks using preexisting infrastructure
Authors: Rabbie Julian , Chakraborty Kaushik , Avis Guus , Wehner Stephanie
Published: January 2022

We consider the problem of deploying a quantum network on an existing fiber infrastructure, where quantum repeaters and end nodes can only be housed at specific locations. We propose a method based on integer linear programming (ILP) to place the minimal number of repeaters on such an existing network topology, such that requirements on end-to-end entanglement-generation rate and fidelity between any pair of end-nodes are satisfied. While ILPs are generally difficult to solve, we show that our method performs well in practice for networks of up to 100 nodes. We illustrate the behavior of our method both on randomly-generated network topologies, as well as on a real-world fiber topology deployed in the Netherlands.
A crowdsourced global data set for validating built-up surface layers
Authors: See Linda , Georgieva Ivelina , Duerauer Martina , Kemper Thomas , Corbane Christina , Maffenini Luca , Gallego Javier , Pesaresi Martino , Sirbu Flavius , Ahmed Rekib , Blyshchyk Kateryna , Magori Brigitte , Blyshchyk Volodymyr , Melnyk Oleksandr , Zadorozhniuk Roman , Mandici Marian-Traian , Su Yuan-Fong , Rabia Ahmed Harb , Pérez-Hoyos Ana , Vasylyshyn Roman , Pawe Chandra Kant , Bilous Svitlana , Kovalevskyi Serhii B. , Kovalevskyi Sergii S. , Bordoloi Kusumbor , Bilous Andrii , Panging Kripal , Bilous Valentyn , Prestele Reinhard , Sahariah Dhrubajyoti , Deka Anjan , Nath Nityaranjan , Neves Rui , Myroniuk Viktor , Karner Mathias , Fritz Steffen
Published: January 2022

Several global high-resolution built-up surface products have emerged over the last five years, taking full advantage of open sources of satellite data such as Landsat and Sentinel. However, these data sets require validation that is independent of the producers of these products. To fill this gap, we designed a validation sample set of 50 K locations using a stratified sampling approach independent of any existing global built-up surface products. We launched a crowdsourcing campaign using Geo-Wiki (https://www.geo-wiki.org/) to visually interpret this sample set for built-up surfaces using very high-resolution satellite images as a source of reference data for labelling the samples, with a minimum of five validations per sample location. Data were collected for 10 m sub-pixels in an 80 × 80 m grid to allow for geo-registration errors as well as the application of different validation modes including exact pixel matching to majority or percentage agreement. The data set presented in this paper is suitable for the validation and inter-comparison of multiple products of built-up areas.
Global holiday datasets for understanding seasonal human mobility and population dynamics
Authors: Lai Shengjie , Sorichetta Alessandro , Steele Jessica , Ruktanonchai Corrine W. , Cunningham Alexander D. , Rogers Grant , Koper Patrycja , Woods Dorothea , Bondarenko Maksym , Ruktanonchai Nick W. , Shi Weifeng , Tatem Andrew J.
Published: January 2022

Public and school holidays have important impacts on population mobility and dynamics across multiple spatial and temporal scales, subsequently affecting the transmission dynamics of infectious diseases and many socioeconomic activities. However, worldwide data on public and school holidays for understanding their changes across regions and years have not been assembled into a single, open-source and multitemporal dataset. To address this gap, an open access archive of data on public and school holidays in 2010–2019 across the globe at daily, weekly, and monthly timescales was constructed. Airline passenger volumes across 90 countries from 2010 to 2018 were also assembled to illustrate the usage of the holiday data for understanding the changing spatiotemporal patterns of population movements.
Arrhythmogenic mechanisms of interleukin-6 combination with hydroxychloroquine and azithromycin in inflammatory diseases
Authors: Zhu Xiaojia , Wang Yuwei , Xiao Yujie , Gao Qianwen , Gao Li , Zhang Wenhui , Xin Xiaofeng , Chen Kesu , Srivastava Ujala , Ginjupalli Vamsi Krishna Murthy , Cupelli Michael , Lazzerini Pietro Enea , Capecchi Pier Leopoldo , Chen Long , Boutjdir Mohamed
Published: January 2022

Inflammatory diseases including COVID-19 are associated with a cytokine storm characterized by high interleukin-6 (IL-6) titers. In particular, while recent studies examined COVID-19 associated arrhythmic risks from cardiac injury and/or from pharmacotherapy such as the combination of azithromycin (AZM) and hydroxychloroquine (HCQ), the role of IL-6 per se in increasing the arrhythmic risk remains poorly understood. The objective is to elucidate the electrophysiological basis of inflammation-associated arrhythmic risk in the presence of AZM and HCQ. IL-6, AZM and HCQ were concomitantly administered to guinea pigs in-vivo and in-vitro. Electrocardiograms, action potentials and ion-currents were analyzed. IL-6 alone or the combination AZM + HCQ induced mild to moderate reduction in heart rate, PR-interval and corrected QT (QTc) in-vivo and in-vitro. Notably, IL-6 alone was more potent than the combination of the two drugs in reducing heart rate, increasing PR-interval and QTc. In addition, the in-vivo or in-vitro combination of IL-6 + AZM + HCQ caused severe bradycardia, conduction abnormalities, QTc prolongation and asystole. These electrocardiographic abnormalities were attenuated in-vivo by tocilizumab (TCZ), a monoclonal antibody against IL-6 receptor, and are due in part to the prolongation of action potential duration and selective inhibition of Na+, Ca2+ and K+ currents. Inflammation confers greater risk for arrhythmia than the drug combination therapy. As such, in the setting of elevated IL-6 during inflammation caution must be taken when co-administering drugs known to predispose to fatal arrhythmias and TCZ could be an important player as a novel anti-arrhythmic agent. Thus, identifying inflammation as a critical culprit is essential for proper management.
Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit
Authors: Liu Shizhen , Zhong Zhihua , Liu Fanna
Published: January 2022

This study evaluated the relationship between hyperuricemia at admission and the clinical prognosis of patients with sepsis. The data were obtained from the Intensive Care Medical Information Database III. The patients were divided into a normal serum uric acid group and a hyperuricemia group. The main outcome was 90-day mortality, and the secondary outcomes were hospital mortality, 30-day mortality, and acute kidney injury. Propensity score matching was used to balance the baseline characteristics of the groups. Our study retrospectively included 954 patients. Before and after propensity score matching, the incidence of AKI, the 30-day and 90-day mortality rates were significantly higher in the hyperuricemia group. Cox regression analysis showed that hyperuricemia was significantly associated with 90-day mortality (HR 1.648, 95% CI 1.215–2.234,p = 0.006), and hyperuricemia was significantly associated with the incidence of AKI (HR 1.773, 95% CI 1.107–2.841,p = 0.017). The Kaplan–Meier survival curve showed that the 90-day survival rate was significantly lower in the hyperuricemia group. In patients with sepsis in the intensive care unit, hyperuricemia was significantly associated with increased risk 90-day all-cause mortality and the incidence of AKI.
Inhibition of MCL1 induces apoptosis in anaplastic large cell lymphoma and in primary effusion lymphoma
Authors: Quentmeier Hilmar , Geffers Robert , Hauer Vivien , Nagel Stefan , Pommerenke Claudia , Uphoff Cord C. , Zaborski Margarete , Drexler Hans G.
Published: January 2022

Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignancies and contributes to tumorigenesis by inhibiting the apoptotic machinery of the cells. Antagonizing BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leukemia and for acute myeloid leukemia. To find additional hematologic entities with ectopic expression of BCL2 family members, we performed expression screening of cell lines applying the LL-100 panel. Anaplastic large cell lymphoma (ALCL) and primary effusion lymphoma (PEL), 2/22 entities covered by this panel, stood out by high expression of MCL1 and low expression of BCL2. The MCL1 inhibitor AZD-5991 induced apoptosis in cell lines from both malignancies, suggesting that this BH3 mimetic might be efficient as drug for these diseases. The ALCL cell lines also expressed BCLXL and BCL2A1, both contributing to survival of the cells. The combination of specific BH3 mimetics yielded synergistic effects, pointing to a novel strategy for the treatment of ALCL. The PI3K/mTOR inhibitor BEZ-235 could also efficiently be applied in combination with AZD-5991, offering an alternative to avoid thrombocytopenia which is associated with the use of BCLXL inhibitors.
Efficacy of adjuvant trastuzumab in women with HER2-positive T1a or bN0M0 breast cancer: a population-based cohort study
Authors: Ali Sanji , Hendry Jace , Le Duc , Mondal Prosanta K. , Sami Amer , Chalchal Haji , Haider Kamal , Ahmed Osama , El-Gayed Ali , Wright Philip , Pauls Mehrnoosh , Johnson Kate , Ahmed Shahid
Published: January 2022

Adjuvant trastuzumab has been associated with superior survival in women with ≥ T1c or node-positive HER2-positive early-stage breast cancer; however, there is a lack of phase III trials in women with T1a/bN0 disease. Our study aimed to assess the outcomes of women with HER2-positive T1a/bN0 breast cancer who received adjuvant trastuzumab in Saskatchewan, Canada. We evaluated all women diagnosed with HER2-positive T1a/bN0 breast cancer in Saskatchewan between 2008 and 2017. We performed Cox proportional multivariable analysis to determine factors correlated with survival. In addition, inverse probability treatment weighting (IPTW) using propensity score was performed to assess benefit of adjuvant trastuzumab. Ninety-one eligible women with a median age of 61 years (range 30–89) were identified. Thirty-nine (43%) women received adjuvant trastuzumab. Women who received trastuzumab were younger and had a higher rate of T1b disease. Overall, 3% of women who received trastuzumab compared to 12% of women who did not receive trastuzumab developed breast cancer recurrence (p = 0.23). Five-year disease-free survival (DFS) of women who received adjuvant trastuzumab was 94.8% compared to 82.7% of women who did not receive trastuzumab (p = 0.22). Five-year overall survival was 100% of women who received trastuzumab compared to 90.4% of women who did not receive adjuvant trastuzumab (p = 0.038). In the multivariable analysis, grade III tumors were correlated with inferior DFS (hazard ratio [HR] 5.5, 95% CI [1.7–17.7]). The propensity score using the inverse probability of treatment weighting showed that lack of adjuvant trastuzumab was correlated inferior DFS, with an HR of 4 (95% CI 1.05–15.5). Women with HER2-positive T1a/bN0 breast cancer had overall low recurrence of breast cancer. However, the results of this exploratory analysis indicate that women who received adjuvant trastuzumab had better survival.
Cooperative allostery and structural dynamics of streptavidin at cryogenic- and ambient-temperature
Authors: Ayan Esra , Yuksel Busra , Destan Ebru , Ertem Fatma Betul , Yildirim Gunseli , Eren Meryem , Yefanov Oleksandr M. , Barty Anton , Tolstikova Alexandra , Ketawala Gihan K. , Botha Sabine , Dao E. Han , Hayes Brandon , Liang Mengning , Seaberg Matthew H. , Hunter Mark S. , Batyuk Alexander , Mariani Valerio , Su Zhen , Poitevin Frederic , Yoon Chun Hong , Kupitz Christopher , Cohen Aina , Doukov Tzanko , Sierra Raymond G. , Dağ Çağdaş , DeMirci Hasan
Published: January 2022

Multimeric protein assemblies are abundant in nature. Streptavidin is an attractive protein that provides a paradigm system to investigate the intra- and intermolecular interactions of multimeric protein complexes. Also, it offers a versatile tool for biotechnological applications. Here, we present two apo-streptavidin structures, the first one is an ambient temperature Serial Femtosecond X-ray crystal (Apo-SFX) structure at 1.7 Å resolution and the second one is a cryogenic crystal structure (Apo-Cryo) at 1.1 Å resolution. These structures are mostly in agreement with previous structural data. Combined with computational analysis, these structures provide invaluable information about structural dynamics of apo streptavidin. Collectively, these data further reveal a novel cooperative allostery of streptavidin which binds to substrate via water molecules that provide a polar interaction network and mimics the substrate biotin which displays one of the strongest affinities found in nature.
Plasticity in visual cortex is disrupted in a mouse model of tauopathy
Authors: Papanikolaou Amalia , Rodrigues Fabio R. , Holeniewska Joanna , Phillips Keith G. , Saleem Aman B. , Solomon Samuel G.
Published: January 2022

Alzheimer’s disease and other dementias are thought to underlie a progressive impairment of neural plasticity. Previous work in mouse models of Alzheimer’s disease shows pronounced changes in artificially-induced plasticity in hippocampus, perirhinal and prefrontal cortex. However, it is not known how degeneration disrupts intrinsic forms of brain plasticity. Here we characterised the impact of tauopathy on a simple form of intrinsic plasticity in the visual system, which allowed us to track plasticity at both long (days) and short (minutes) timescales. We studied rTg4510 transgenic mice at early stages of tauopathy (5 months) and a more advanced stage (8 months). We recorded local field potentials in the primary visual cortex while animals were repeatedly exposed to a stimulus over 9 days. We found that both short- and long-term visual plasticity were already disrupted at early stages of tauopathy, and further reduced in older animals, such that it was abolished in mice expressing mutant tau. Additionally, visually evoked behaviours were disrupted in both younger and older mice expressing mutant tau. Our results show that visual cortical plasticity and visually evoked behaviours are disrupted in the rTg4510 model of tauopathy. This simple measure of plasticity may help understand how tauopathy disrupts neural circuits, and offers a translatable platform for detection and tracking of the disease.
How the motor system copes with aging: a quantitative meta-analysis of the effect of aging on motor function control
Authors: Zapparoli Laura , Mariano Marika , Paulesu Eraldo
Published: January 2022

Motor cognitive functions and their neurophysiology evolve and degrade along the lifespan in a dramatic fashion. Current models of how the brain adapts to aging remain inspired primarily by studies on memory or language processes. Yet, aging is strongly associated with reduced motor independence and the associated degraded interaction with the environment: accordingly, any neurocognitive model of aging not considering the motor system is, ipso facto, incomplete. Here we present a meta-analysis of forty functional brain-imaging studies to address aging effects on motor control. Our results indicate that motor control is associated with aging-related changes in brain activity, involving not only motoric brain regions but also posterior areas such as the occipito-temporal cortex. Notably, some of these differences depend on the specific nature of the motor task and the level of performance achieved by the participants. These findings support neurocognitive models of aging that make fewer anatomical assumptions while also considering tasks-dependent and performance-dependent manifestations. Besides the theoretical implications, the present data also provide additional information for the motor rehabilitation domain, indicating that motor control is a more complex phenomenon than previously understood, to which separate cognitive operations can contribute and decrease in different ways with aging.
High efficiency capture of biomarker miRNA15a for noninvasive diagnosis of malignant kidney tumors
Authors: Renner Alexander M. , Derichsweiler Christina , Ilyas Shaista , Gessner Isabel , Fries Jochen W. U. , Mathur Sanjay
Published: January 2022

A non-invasive diagnostic tool for RCCviamagnetic carriers, utilizing miRNA15a as a biomarker offers several advantages over the “gold standard” of qRT-PCR in terms of: handling, equipment needed, duration, ease of test manufacturing and costs.
Bi- and trimetallic complexes with macrocyclic xanthene-4,5-diNHC ligands
Authors: Kaps Alexander , Foro Sabine , Plenio Herbert
Published: January 2022

Three different types of bimetallic NHC-metal complexes were synthesized, whose NHC units are attached at the 4,5-positions of xanthene.
An Fe-doped Co-oxide electrocatalyst synthesized through a post-modification method toward advanced water oxidation
Authors: Xu Zhenhang , Zuo Wei , Shi Tianyu , Liu Xinghai , Li Houbin , Zhao Pingping , Cheng Gongzhen
Published: January 2022

A new type of Fe-doped Co-oxide electrocatalyst Co3−xFexO4-0.01 exhibited excellent OER activity at a current density of 10 mA cm−2. The introduction of Fe not only successfully achieved the synergistic effect of CoFe, but also promoted the formation of oxygen bridges.
The Sea Spray Chemistry and Particle Evolution study (SeaSCAPE): overview and experimental methods
Authors: Sauer Jon S. , Mayer Kathryn J. , Lee Christopher , Alves Michael R. , Amiri Sarah , Bahaveolos Cristina J. , Franklin Emily B. , Crocker Daniel R. , Dang Duyen , Dinasquet Julie , Garofalo Lauren A. , Kaluarachchi Chathuri P. , Kilgour Delaney B. , Mael Liora E. , Mitts Brock A. , Moon Daniel R. , Moore Alexia N. , Morris Clare K. , Mullenmeister Catherine A. , Ni Chi-Min , Pendergraft Matthew A. , Petras Daniel , Simpson Rebecca M. C. , Smith Stephanie , Tumminello Paul R. , Walker Joseph L. , DeMott Paul J. , Farmer Delphine K. , Goldstein Allen H. , Grassian Vicki H. , Jaffe Jules S. , Malfatti Francesca , Martz Todd R. , Slade Jonathan H. , Tivanski Alexei V. , Bertram Timothy H. , Cappa Christopher D. , Prather Kimberly A.
Published: January 2022

The SeaSCAPE campaign replicated the marine atmosphere in the laboratory to investigate the links between biological activity in the ocean and the properties of primary sea spray aerosols, volatile organic compounds, and secondary marine aerosols.
Synthesis of carbon-based nanomaterials and their application in pollution management
Authors: Liu Zhixin , Ling Qian , Cai Yawen , Xu Linfeng , Su Jiahao , Yu Kuai , Wu Xinyi , Xu Jiayi , Hu Baowei , Wang Xiangke
Published: January 2022

With the fast development of industry, large amounts of organic and inorganic pollutants are inevitably released into the natural environment, which results in the pollution of the environment and are thereby dangerous to human health.
Sarcanolides C–E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra
Authors: Xiao Long-Gao , Li Ping , Yan Huan , Ni Wei , He Li , Liu Hai-Yang
Published: January 2022

Sarcanolide C (1) with an unusual orthoformate unit, together with two new lindenane-type sesquiterpenoid dimers were isolated from the roots of Sarcandra glabra.
Ni@C catalyzed hydrogenation of acetophenone to phenylethanol under industrial mild conditions in a flow reactor
Authors: Lin Shanshan , Liu Jianguo , Ma Longlong
Published: January 2022

The catalytic hydrogenation of organic substrates containing plenty of unsaturated functional groups is an important step in the industrial preparation of fine chemicals and has always been a hot spot in basic catalysis research.
New insights on MXene and its advanced hybrid materials for lithium-ion batteries
Authors: Jyoti Jeevan , Singh Bhanu Pratap , Sandhu Manjit , Tripathi Surya Kant
Published: January 2022

Electrode materials with exceptional cyclic stability and high-rate performance have been in extensive demand for the fast growth of energy storage applications.
Membrane mixing and dynamics in hybrid POPC/poly(1,2-butadiene-block-ethylene oxide) (PBd-b-PEO) lipid/block co-polymer giant vesicles
Authors: Seneviratne Rashmi , Catania Rosa , Rappolt Michael , Jeuken Lars J. C. , Beales Paul A.
Published: January 2022

Homogeneous hybrid vesicles where lipid diffusion decreases with increasing polymer content but polymer diffusion is minimally affected by lipid composition.
An anisotropic immerse precipitation process for the preparation of polymer membranes
Authors: Qiu Xuwen , Mao Sheng , Yin Jun , Yang Yantao
Published: January 2022

Finger-like patterns generated through anisotropic mobility were compared to chaotic patterns generated through isotropic mobility.
Dynamics of active particles with space-dependent swim velocity
Authors: Caprini Lorenzo , Marini Bettolo Marconi Umberto , Wittmann René , Löwen Hartmut
Published: January 2022

We present analytical results for an active particle in a motiity landscape.
Anisotropic conductive shape-memory aerogels as adaptive reprogrammable wearable electronics for accurate long-term pressure sensing
Authors: Huang Jinhui , Wang Yilei , Guo Jing , Wu Shanshan , Xie Hui , Zhou Shaobing
Published: January 2022

The reprogrammable shape-memory effect of the anistropic aerogel-based sensing electronics enables adaptive wearability, potentially ensuring accurate long-term physical monitoring without suppressing inherent excellent pressure-sensing performance.
A fast self-charging and temperature adaptive electrochromic energy storage device
Authors: Wang Yue , Zhong Xiaolan , Liu Xueqing , Lu Zelin , Su Yingjie , Wang Mengying , Diao Xungang
Published: January 2022

ECESDs exhibit a wide operating temperature range. They can be chemically self-charged through a spontaneous redox reaction and the energy status could be estimated by the naked eye according to the obvious color during the charge/discharge process.
Molecular simulations of zwitterlation-induced conformation and dynamics variation of glucagon-like peptide-1 and insulin
Authors: Qiao Qi , Cai Lirong , Shao Qing
Published: January 2022

Zwitterionic materials have shown their ability to improve the circulation time and stability of proteins.
Uniform arrays of centre-type topological domains in epitaxial ferroelectric thin films
Authors: Li Zhongwen , Shen Hui , Dawson Graham , Zhang Zhengzhong , Wang Yanzong , Nan Feng , Song Guang , Li Guannan , Wu Yangjiang , Liu Hao
Published: January 2022

Spontaneous ferroelectric topological domains are observed in epitaxial BFO films using PFM. The uniform arrays of centre domain structures and their reversible switching are realized utilizing PFM tip-fields assisted by the mobile charges.
Metallization and superconductivity of NBH12 compounds stabilized by dihydrogen bonds
Authors: Shi Lan-Ting , Turnbull Robin , Liang Akun , Chen Xiang-Rong , Ji Guang-Fu
Published: January 2022

As the most promising hydrogen storage material, ammonia borane (NH3BH3, AB) has been the subject of study in a variety of scientific fields.
Dynamic covalent chemistry constrained diphenylethenes: control over reactivity and luminescence both in solution and in the solid state
Authors: Jiang Guoshan , Hai Yu , Ye Hebo , You Lei
Published: January 2022

A combination of diphenylethene and dynamic covalent chemistry for the modulation of reactivity and luminescence, stimuli-responsive multistate emission, and mechanochemical reactions in the solid state.
Teaching Parents Read, Ask, Answer, Prompt Strategies via Telepractice: Effects on Parent Strategy Use and Child Communication
Authors: Dodge-Chin Cheri , Shigetomi-Toyama Sandra , Quinn Emily D.
Published: January 2022

Purpose:

This study aimed to explore the feasibility of a telepractice communication partner intervention for children who use augmentative and alternative communication (AAC) and their parents.

Method:

Five children (aged 3;4–12;9 [years;months]) with severe expressive communication impairments who use AAC and their parents enrolled in a randomized, multiple-probe design across participants. A speech-language pathologist taught parents to use a least-to-most prompting procedure, Read, Ask, Answer, Prompt (RAAP), during book reading with their children. Parent instruction was provided through telepractice during an initial 60-min workshop and five advanced practice sessions (
M
= 28.41 min). The primary outcome was parents' correct use of RAAP, measured by the percentage of turns parents applied the strategies correctly. Child communication turns were a secondary, exploratory outcome.

Results:

There was a functional relation (intervention effect) between the RAAP instruction and parents' correct use of RAAP. All parents showed a large, immediate increase in the level of RAAP use with a stable, accelerating (therapeutic) trend to criterion after the intervention was applied. Increases in child communication turns were inconsistent. One child increased his communication turns. Four children demonstrated noneffects; their intervention responses overlapped with their baseline performance.

Conclusions:

Telepractice RAAP strategy instruction is a promising service delivery for communication partner training and AAC interventions. Future research should examine alternate observation and data collection and ways to limit communication partner instruction barriers.
A Survey of Speech-Language Pathology Graduate Students' Perceptions of Telepractice Pre- and Posttraining During the COVID-19 Pandemic
Authors: Hatcher Allison , Frost Kelly , Weiler Brian , Bland Lauren
Published: January 2022

Purpose:

Many university programs in speech-language pathology that offer clinical training as part of their graduate training transitioned to a telepractice service delivery model in response to the COVID-19 pandemic. The purpose of this study was to survey speech-language pathology graduate student clinicians on their knowledge of and comfortability with telepractice before and after participation in a telepractice training program.

Method:

Graduate students in a speech-language pathology distance program participated in a remote summer clinical internship that included a 5-week telepractice training. Pre- and posttraining surveys were completed by 27 graduate students.

Results:

Results of a Wilcoxon signed-ranks test indicated that posttest telepractice knowledge question scores were significantly greater than pretest telepractice knowledge question scores. Likewise, posttest telepractice comfort question scores were significantly greater than pretest telepractice comfort question scores.

Conclusions:

These findings support the need to integrate a telepractice component to clinical education for speech-language pathology programs at the graduate level. Offering a specifically designed and hands-on telepractice training to graduate students in speech-language pathology can be an effective pedagogical piece to university degree programs.
Continuum, cyclotron line, and absorption variability in the high-mass X-ray binary Vela X-1
Authors: Diez C. M. , Grinberg V. , Fürst F. , Sokolova-Lapa E. , Santangelo A. , Wilms J. , Pottschmidt K. , Martínez-Núñez S. , Malacaria C. , Kretschmar P.
Published: January 2022

Because of its complex clumpy wind, prominent cyclotron resonant scattering features, intrinsic variability, and convenient physical parameters (close distance, high inclination, and small orbital separation), which facilitate the observation and analysis of the system, Vela X-1 is one of the key systems for understanding accretion processes in high-mass X-ray binaries on all scales. We revisit Vela X-1 with two new observations taken with NuSTAR at orbital phases ∼0.68–0.78 and ∼0.36–0.52, which show a plethora of variability and allow us to study the accretion geometry and stellar wind properties of the system. We follow the evolution of spectral parameters down to the pulse period timescale using a partially covered power law continuum with a Fermi-Dirac cutoff to model the continuum and local absorption. We are able to confirm anti-correlations between the photon index and the luminosity and, for low fluxes, between the folding energy and the luminosity, implying a change of properties in the Comptonising plasma. We were not able to confirm a previously seen correlation between the cyclotron line energy and the luminosity of the source in the overall observation, but we observed a drop in the cyclotron line energy following a strong flare. We see strong variability in absorption between the two observations and within one observation (for the ∼0.36–0.52 orbital phases) that can be explained by the presence of a large-scale structure, such as accretion and photoionisation wakes in the system, and our variable line of sight through this structure.
Impact of Limestone Deposit Operation on the Yield of Surrounding Agricultural Land: Case of the Western Rif, Morocco
Authors: Fattah Ghizlane , Ghrissi Fouzia , Mabrouki Jamal , Cherifi Hicham
Published: January 2022

The exploitation of the limestone deposit is carried out in the open air. Its exploitation process has obvious effects on its environment, and in particular on agricultural production in neighboring lands, by suspending fine particles of matter in the air, which can potentially settle in the soil and the water. The latter being essential resources in the agricultural production process. The analysis of the quality of these resources located near the exploited zone as well as in a control zone (reference zone), both located at the level of the mountain of Haouz, of the western Rif, made it possible to assess the ’impact of the exploitation of the limestone deposit on the physico-chemical characteristics of soils and surface water. Soil and water samples were taken in these areas. The results of these analyzes made it possible to assess the level of soil fertility at each identified sampling point, as well as the characterization of surface water intended for irrigation. The results revealed that this exploitation leads to a significant modification of the soil profile of the neighboring agricultural lands, making them less fertile. This exploitation also causes a hardening of the surface layer of the soil, favoring the phenomenon of encrustation of the soil. The only positive point is that surface water is endowed with essential nutrients such as magnesium and phosphorus originating from the dust emitted during the extraction of limestone. An excessive presence of suspended matter could be accompanied by an increase in pH and thus promote the phenomenon of encrustation of soils when they are irrigated. This reveals that the exploitation of the deposits has generally negative physical and chemical impacts on the soil and consequently on agricultural production.
Carcass and meat quality characteristics of Beni-Guil autochthonous ovine breed: effect of live weight at slaughter
Authors: Belhaj Kamal , Mansouri Farid , Rbah Youssef , Allay Aymane , Melhaoui reda , Tikent Aziz , Taaifi Yassine , Benmoumen Abdessamad , Boukharta Mohamed , Sindic Marianne , Serghini-Caid Hana , Elamrani Ahmed
Published: January 2022

Ninety female lambs of the Beni-Guil sheep breed were used to study the effect of slaughter live weight (SLW) on carcass characteristics and meat quality. The animals were raised in Morocco’s eastern area under a pastoral-transhumant system. The lambs were slaughtered at three weight classes (SLW1 =20-25 kg, SLW2 = 26-30 kg, SLW3 = 31-35 kg). Ultimate pH value (pHu), fat and meat color, zoometric measurement, conformation score, fatness state, and fat consistency were evaluated 24 h post-slaughter. The carcass measures and compactness indexes increase with higher SLW (p<0.001). However, the dressing percentage and shrinkage were not affected. The longissimus lumborum muscle was used for meat quality determination. The pHu was not affected (p>0.05) by SLW effect. With respect to meat color, the lightness (L*) decreased with increasing SLW, while the redness increased (p<0.05). The female lambs with a carcass weight of 20-25 kg have a higher L* value (41.89), and lambs with a carcass weight between 31 and 35 kg have a higher redness value (21.73). In relation to the c1arcass fatness state and carcass conformation, the SLW had a significant effect (p<0.001). The conformation and the fatness increase in the logical sequence of SLW.
Capacity estimation based on incremental capacity and Gaussian process regression for retired lithium-ion batteries
Authors: Sun Wei , Jin Peng , Liao Xiawei , Ma Xiaoming , Yang Bo
Published: January 2022

Fast capacity estimation for retired batteries is necessary when batteries are recycled for echelon utilization. Here, a fast capacity estimation method is proposed for retired LiFePO4 battery. First, a full survey of battery pack and cells degradation after a long period of service is studied. Then the filtered ICA is used to study degradation variation phenomenon of retired batteries, the relationship between IC curve feature and remaining capacity was studied. Finally, a fast capacity estimation using incremental capacity and Gaussian process regression is proposed. Our results show high efficiency and accuracy of the proposed method.
Study on the difference of pore structure characteristics between the main oil reservoir and the second oil reservoir in Daqing Oilfield
Authors: Teng Hongda
Published: January 2022

In order to study the difference of pore structure characteristics between the second oil reservoir and the main oil reservoir in Daqing oilfield, the pore structure characteristic parameters of core were characterized by routine mercury injection experiment. The results show that the average pore radius of the main reservoir ranges from 5.24μm to 12.50μm, the sorting coefficient ranges from 1.14 to 3.08, the median saturation pressure ranges from 0.04MPa to 0.27MPa, and the maximum median radius can reach 15μm. The permeability is high and the displacement pressure is low. The average pore radius of the second type reservoir is in 2.21μm~9.03μm, the sorting coefficient is 2.70~4.77, the median saturation pressure is 0.076MPa~5.148MPa, the maximum radius is only 5μm, and the permeability is low and the displacement pressure is high. It is important to clarify the difference of reservoir pore structure characteristics for efficient reservoir development.
A review of hyperspectral remote sensing of crops
Authors: Xia Liheng , Wu Xueying
Published: January 2022

With the development of space science and technology, various resource monitoring environmental satellites provide multi-platform, multi-spectral, multi-temporal and wide-range real-time information for the study of surface dynamic changes, and remote sensing technology has become a powerful technical means for human to study the earth’s resources and environment, while high-resolution and hyperspectral remote sensing has become the main source for fruit tree growth monitoring and fruit quality detection acquisition. This paper has the following aspects to introduce the current situation of application of high-resolution and hyperspectral remote sensing data.
Literature Review on Farmland Landscape Pattern Change Analysis
Authors: Mu Zhezhe
Published: January 2022

Farmland landscape pattern refers to the composition and spatial distribution of landscape elements in a certain spatial range. Farmland landscape pattern formation has natural, historical, cultural and other factors. Since the reform and opening up, China’s rapid socio-economic development, urbanization and a series of social development caused a large number of land occupation, farmland landscape pattern has undergone major changes. Domestic and foreign scholars based on natural geography, landscape ecology, combined with 3S technology, FRAGSTATES landscape index calculation method, from the aspects of landscape evolution process, landscape heterogeneity and diversity and landscape dynamics and driving factors correlation, analyzes the characteristics of regional landscape pattern change, and on this basis, analyzes the influence mechanism and correlation of landscape pattern succession. However, at present, most studies are based on the time axis, focusing on the changes of landscape patterns such as forests, wetland waters and towns. There are relatively few studies on the changes of farmland landscape patterns, and there are relatively few studies on the combination of time and space. Therefore, through the study and analysis of the characteristics of farmland landscape pattern change, the driving factors of landscape pattern change are known, and on this basis, the methods and ways of landscape pattern optimization are studied to provide scientific basis for constructing and optimizing farmland ecosystem, regional ecological network and protecting biodiversity.
Research on Monitoring Information Management of Deep Foundation Pit Engineering Based on BIM Technology
Authors: Wang Peng , Li Yan , Wang Na
Published: January 2022

With the rapid development of construction industry, there are more and more deep and large foundation pit projects with complex architectural environment and geological conditions. Deformation monitoring in deep foundation pit as a basic element of engineering quality assurance is becoming more and more important. At present, the management and expression form of monitoring data in deep foundation pit still stays in the stage of two-dimensional form and curve expression, and it can not reflect the deformation of deep foundation pit in real, fast and effective way.Take the 3#, 4# high-rise residential and underground garage project of a college in Xi'an as an example. Based on Revit software, taking BIM technology and Revit API as the theoretical basis, and taking Microsoft Visual Studio 2012 and Autodesk Revit 2014 as the development platform, we use C# programming language to carry out the two development of information management module for deep foundation pit engineering monitoring. Combining BIM technology with monitoring data management of deep foundation pit, the information management mode of monitoring data of deep foundation pit is improved, which makes express expression of deep foundation pit construction monitoring more rapid and effective, and has guiding significance for safety construction of deep foundation pit engineering.
Recycling of chromium sludge to promote aggregation and growth of metal during self-reduction of nickel laterite ore
Authors: Yu Hui , Song Shengqiang , Cromarty Robert , Hang Guihua , Hu Qian , Zhang Wenke , Liu Dongming , Xue Zhengliang
Published: January 2022

Addition of stainless steel pickling sludge, which contains hazardous hexavalent chromium, to low-grade nickel laterite ore has the potential to eliminate the hexavalent chromium and promote the aggregation and growth of iron-nickel particles during reduction with anthracite. The effect of chromium sludge on the aggregation and growth of metal particles during a self-reduction process of nickel laterite ore has been studied. The detoxification effect of hexavalent chromium in the sludge was evaluated using the standard TRGS 613 leaching test. Results showed that with increasing chromium sludge addition, the size of metal particles increased. With the addition of 13.94% by mass chromium sludge the average metal particle size in the reduce ore increased from 0.42 µm to 1.38 µm while the recovery of Fe, Ni and Cr increased from 53.73%, 19.39% and 33.36% to 78.33%, 69.22% and 58.26%, respectively. It is proposed that a low melting point eutectic phase of FeS formed in the reduced products, significantly promoted the migration and aggregation of metal particles. Leaching tests indicated that the original chromium sludge released > 600 mg/kg Cr(VI) while the slag from the combined laterite and chromium sludge released less than the EPA limit of 2 mg/kg Cr(VI).
Watch Your Back: Development and Usability of a Visual Feedback System for People with Low Back Pain – A Single Subject Usability Study
Authors: Heussler Moana , Winter Jasmin , Hotz-Boendermaker Sabina , Bauer Christoph Michael
Published: January 2022

Background To find effective treatments for low back pain remains a major challenge in physical therapy. Numerous treatment methods currently exist, but the use of real-time visual feedback is a promising new therapeutic approach. The opportunities for its implementation and use require further research.

Objective To develop a video-supported system for visual feedback and to test its usability.

Method The prototype of a video-based system for visual feedback was developed and tested on a person with persistent unspecific lumbar back pain. The system was evaluated through an interview with the subject and the system usability scale (SUS).

Results The subject was optimistic about the system’s functionality. He was astonished to see his own back while moving, which triggered positive emotions. He also found the apparatus comfortable to wear. The system achieved a value of 77.5 out of 100 on the SUS, which represents good usability.

Conclusion By means of technical adjustments to avoid a delay in transmission and an exact positioning of the monitor, further improvements in the usability can be achieved. More research will be required to evaluate the efficacy of the developed system in the treatment of lumbar back pain.
Lesão muscular: Fisiopatologia, diagnóstico e tratamento
Authors: SantAnna João Paulo Cortez , Pedrinelli André , Hernandez Arnaldo José , Fernandes Tiago Lazzaretti
Published: January 2022

O tecido muscular esquelético possui a maior massa do corpo humano, correspondendo a 45% do peso total. As lesões musculares podem ser causadas por contusões, estiramentos ou lacerações. A atual classificação separa as lesões entre leves, moderadas e graves. Os sinais e sintomas das lesões grau I são edema e desconforto; grau II, perda de função, gap e equimose eventual; grau III, rotura completa, dor intensa e hematoma extenso. O diagnóstico pode ser confirmado por ultrassom (dinâmico e barato, porém examinador-dependente); e ressonância magnética (RM) (maior definição anatômica). A fase inicial do tratamento se resume à proteção, ao repouso, ao uso otimizado do membro afetado e crioterapia. Anti-inflamatórios não hormonais (AINHs), ultrassom terapêutico, fortalecimento e alongamento após a fase inicial e amplitudes de movimento sem dor são utilizados no tratamento clínico. Já o cirúrgico possui indicações precisas: drenagem do hematoma, reinserção e reforço musculotendíneos.
Doença de Van Neck-Odelberg — Entidade rara ou subdiagnosticada?
Authors: Moreira Mafalda , Alba Diana , Nogueira Hélder , Teixeira Sandra
Published: January 2022

A doença de Van Neck-Odelberg (VNO) é uma osteocondrose rara, que acomete a sincondrose isquiopúbica (SIP). Esta entidade deve ser incluída no diagnóstico diferencial de crianças com claudicação na marcha, dor inguinal e limitação funcional do quadril. Imagiologicamente é caracterizada por hipertrofia assimétrica da SIP. Apresentamos o caso clínico de uma criança de 4 anos, previamente saudável, atendida no serviço de emergência devido a dor inguinal no lado esquerdo e claudicação na marcha com início no mesmo dia. Não havia história prévia de trauma ou alteração dos parâmetros inflamatórios. Foi realizada uma radiografia da bacia e ressonância magnética nuclear (RMN) que evidenciou imagem radiopaca de contornos bem definidos no ramo isquiopúbico esquerdo e edema na SIP. Com diagnóstico provável de doença de VNO, o paciente foi medicado sintomaticamente, com resolução completa ao fim de 10 dias. A claudicação na marcha é um motivo frequente de avaliação médica na população pediátrica. Até os 5 anos de idade, as causas mais comuns são sinovite transitória do quadril, artrite séptica e Doença de Legg-Calvé-Perthes. Na ausência de história de trauma ou clínica sugestiva de infeção deverá ser equacionada a hipótese de doença de VNO. Para o seu diagnóstico, é fundamental a realização de radiografia da bacia, cujo achado mais comum é uma opacificação fusiforme unilateral, no nível do ísquion, podendo ser necessária a realização de RMN. O tratamento recomendado é conservador, com recuperação sintomática em 2 semanas. O conhecimento e o diagnóstico desta entidade permitem uma abordagem direcionada e sem a carga emocional para o paciente e seus familiares que outras patologias poderiam transmitir.
Arthroscopic Bone Graft and Internal Fixation of Non-Union of the Proximal Pole of the Scaphoid: Surgical Technique and Outcomes
Authors: Ecker Jeff , Shahbaz Laiba , Kohli Sukhsimran , Breidahl William , Andrijich Courtney
Published: January 2022

Background Fractures of the proximal pole of the scaphoid have been associated with delayed union, non-union, and avascular necrosis. This has been attributed to avascularity of the proximal pole of the scaphoid. While proximal pole non-unions can be successfully treated using open techniques, there is little information in the literature regarding arthroscopic bone graft and internal fixation of proximal pole non-unions.

Description of Technique After insertion of a 1.2-mm radiolunate K-wire, the scaphoid non-union was arthroscopically excised, bone grafted with iliac crest cancellous bone, and internally fixed with 3 × 1.2 mm K-wires.

Patients and Methods This is a retrospective study of patients who had arthroscopic bone graft of non-union of the proximal pole of the scaphoid between 2009 and 2021.

Results There were 30 cases in this study; 29 cases united. The one case that did not unite was caused by inadequate fixation of the proximal pole. The size of the proximal pole did not influence the outcome.

Conclusion Arthroscopic bone graft and internal fixation is a reliable technique for the treatment of non-union of the proximal pole of the scaphoid.