bluuebunny/crossref_metadata_2025 huggingface dataset:
The new K, Pb-bearing uranyl-oxide mineral kroupaite: Crystal-chemical implications for the structures of uranyl-oxide hydroxy-hydrates
Authors: Plášil Jakub , Kampf Anthony R. , Olds Travis A. , Sejkora Jiří , Škoda Radek , Burns Peter C. , Čejka Jiří
Published: January 2020

Kroupaite (IMA 2017-031), ideally KPb0.5[(UO2)8O4(OH)10]·10H2O, is a new uranyl-oxide hydroxylhydrate mineral found underground in the Svornost mine, Jáchymov, Czechia. Electron-probe micro-analysis (WDS) provided the empirical formula (K1.28Na0.07)Σ1.35(Pb0.23Cu0.14Ca0.05Bi0.03Co0.02Al0.01)Σ0.48 [(UO2)7.90(SO4)0.04O4.04(OH)10.00]·10H2O, on the basis of 40 O atoms apfu. Sheets in the crystal structure of kroupaite adopt the fourmarierite anion topology, and therefore kroupaite belongs to the schoepite-family of minerals with related structures differing in the interlayer composition and arrangement, and charge of the sheets. Uptake of dangerous radionuclides (90Sr or 135Cs) into the structure of kroupaite and other uranyl-oxide hydroxy-hydrate is evaluated based on crystal-chemical considerations and Voronoi-Dirichlet polyhedra measures. These calculations show the importance of these phases for the safe disposal of nuclear waste.
New insights into the nature of glauconite
Authors: López-Quirós Adrián , Sánchez-Navas Antonio , Nieto Fernando , Escutia Carlota
Published: January 2020

Glauconite must be assessed as mica-rich mica-smectite R3 interstratified mineral, with the pure end-member mica also having intrinsic K-deficient chemical characteristics (K+ ~ 0.8 apfu). This assertion is in accordance with our X-ray diffraction (XRD) and high-resolution tranmission electron microscopy (HRTEM) studies and chemical analyses by electron probe microanalysis (EPMA) of mature glauconites in Cenozoic Antarctic sediments that indicate that: (1) It consists of a glauconite-smectite (R3 ordered) mixed-layer silicate, composed mainly of mica-type layers (>90%), but displaying slightly different proportions of Fe(III)-smectite layers (<10%). (2) More mature glaucony grains are characterized by major K+ and VIFe2+ (mica layers) and minor VIFe3+ (smectite layers) content in the interstratified glauconite-smectite. (3) Potassium is stabilized at the interlayer site by the octahedrally coordinated Fe2+. (4) Microtexture of the glauconite crystals are comparable with those of other micas and illite minerals, with straight, defect-free lattice fringes of ~10 Å spacings glauconite packets characteristic of mica with minor interstratified poorly crystalline smectite layers. In addition, our new findings give insights into the glauconitization process and at the same time investigate the potassium-deficient character of the dioctahedral mica “glauconite.” These findings show that glauconite crystallizes by a layer-growth mechanism at the expense of a poorly crystalline smectite precursor and that smectiteto-glauconite transformations are accompanied by a gradually higher octahedral charge deficiency (Fe2+/Fe3+) stabilized by K+ uptake into the interlayer sheet.
O processo de ensino e aprendizagem de Biologia em consonância com a educação do campo, sob a perspectiva da sustentabilidade
Authors: Salustino Leandro Mendes
Published: January 2020

O objetivo da presente pesquisa foi aplicar alternativas pedagógicas voltada ao ensino e a aprendizagem de Biologia, em consonância com a Educação do Campo e sob a perspectiva da sustentabilidade, com os alunos do 1º ano do Ensino Médio da Escola Estadual de Ensino Fundamental e Médio Campo, Sementes e Mudas, Município de Cruz do Espírito Santo, Estado da Paraíba, Nordeste do Brasil. A pesquisa foi metodologicamente desenvolvida de forma multidisciplinar, a partir de uma abordagem qualitativa, buscando-se identificar algumas variáveis acerca do desenvolvimento de práticas pedagógicas que viessem a auxiliar o processo de ensino e aprendizagem na área disciplinar de Biologia. Realizaram-se visitas a produtores da agricultura familiar que estavam exercendo práticas agrícolas exitosas em suas propriedades. No decorrer das ações, os alunos tiveram a oportunidade de participar de uma palestra com uma técnica agrícola, sobre a agricultura familiar, participaram de atividades práticas, como a confecção de composteira doméstica, fizeram uma ação efetiva de cuidado com o meio ambiente ao realizarem a coleta de garrafas PET, cordão de rede, fio de cadeira, dentre outros materiais. Conclui-se que todas as atividades propostas fizeram com que os alunos desenvolvessem múltiplas habilidades relacionadas ao currículo das disciplinas envolvidas, quanto de aspectos relacionados a habilidades e atitudes socioemocionais e fortalecimento das relações interpessoais.
Arsenic quantification techniques and ISO/IEC 17025 accreditation in Brazil
Authors: Santos Jefferson Luiz Antunes , Busato Jader Galba , Heringer Rodrigo de Almeida , Silva Juscimar da , Dobbss Leonardo Barros
Published: January 2020

The importance of arsenic (As) quantification in environmental compartments is due to its risks to ecosystems and public health. There are reports of high concentrations of this metalloid in Brazil and technological differences between states are observed. The objective of this work was to present and discuss current scenarios of accreditation and compare the limit of quantification (LOQ) of As by analytical technique in Brazil. Data from accredited laboratories were collected on Inmetro website and in state metrological networks and then grouped and analyzed by state, matrix and analytical technique. There are large discrepancies between the number of laboratories per state and a good correlation with gross domestic product (GDP). Almost all laboratories have a LOQ less than the environmental limits. The observed list of techniques sorted from lowest to highest LOQ values is: for liquid samples ICP MS (inductively coupled plasma mass spectrometry), ET AAS (electrothermal atomic absorption spectrometry), HG AAS (hydride generation combined with atomic absorption spectrometry) or HG ICP OES (hydride generation combined with inductively coupled plasma optical emission spectrometry) and UV VIS (visible ultraviolet spectroscopy); for solids samples HG ICP OES, ICP MS, HG AAS, ET AAS and FAAS (flame atomic absorption spectrometry); and for bioindicators ICP MS, HG ICP OES. Analysis of As species is accredited in only one laboratory, but does not include all species.
19. YÜZYIL SONLARINDA AVRUPA’DA BİR ARAP MUHALİF: NECİB HİNDİYE VE HİLAFET GAZETESİ
Authors: ŞAHİN Emine
Published: January 2020

Suriyeli bir Keldanî olan Necib Hindiye uzun yıllar İstanbul’da yaşamış ve 1870’lerde Arap ilim adamı Ahmed Faris’in sahibi olduğu el-Cevâib gazetesinde çalışmıştır. 1885-1887 yıllarında ise Selim Faris’in Kahire’de çıkarmış olduğu el-Kahire ve el-Kahire el-Hurre gazetelerinin editörlüğünü yapmıştır. Bu yıllarda Sultan Abdülhamid’e karşı bağlılığını bildiren bir Osmanlı vatandaşı iken 1890’larda Londra’da muhalif bir aydın olarak karşımıza çıkmaktadır. Londra’da Selim Faris ve çevresine yakın duran Hindiye, 1899 yılında uygun bir zemin bulduğu anda, Türk ve Arap Vatanperver Cemiyeti’nin bir organı olarak Hilafet gazetesini çıkarmıştır. On beş̧ günde bir yayınlanan bu gazete Arapça ve Türkçe olarak basılmıştır. Hilafet, Osmanlı hükümeti tarafından yakın takibe alınmış ve zararlı bir neşriyat olduğuna hükmedilerek ülkeye girişi yasaklanmıştır. Bu çalışmada Avrupa’da Arap ayrılıkçı söylemleriyle öne çıkan ilk isimlerden biri olan Necib Hindiye ve onunla birlikte Osmanlı basın tarihinde az bilinen Hilafet gazetesi ayrıntılı olarak ele alınmakta ve buradan hareketle II. Abdülhamid döneminde Londra’da oluşan Arap ayrılıkçı muhalefet anlatılmaktadır.
Role of Corporate Governance in the Voluntary Disclosure of Intellectual Capital
Authors: Kamat G Bharathi
Published: January 2020

The research on intangible assets and its contribution to the value creation of the firms has received significant attention in recent times.  This paper attempts to estimate and analyse the nature and extent of overall Intellectual Capital Disclosure (ICD) and its sub-components in the annual reports of Information Technology (IT) industry in India for the FY 2017-18. It also attempts to examine whether Corporate Governance Characteristics of these firms influence their ICD. Multiple linear regression analysis is used to evaluate the data on information technology Industry. IT firms in India disclose a very high extent of Human capital; whereas the nature of disclosure is high in case of Structural Capital. The empirical evidence suggests that board size, its independence and ownership pattern of the firm play a significant role in the extent of overall intellectual capital disclosures in Indian IT firms.  The result on impact of corporate governance characteristics varies with respect to the IC sub-components.
Predicting Youngster’s Attitude towards Online Food Delivery
Authors: Dave Anupama Chirag , Trivedi Rinky
Published: January 2020

Attitude has been a very significant topic in the area of consumer research owing to the role it plays in consumer decision making process. Literatures have identified various models that can measure attitude; for this research ABC model of attitude was used. The purpose of this study was to measure the attitude of respondents for OFD and their by analyzing the impact of each component of ABC model on Attitude creation. The data was collected from 368 youngsters using a structured questionnaire. Using SPSS 21, computer software the type of attitude was measured and for achieving second objective AMOS 21.0 software was used. Once the model fit was achieved using AMOS 21.0 the structured equation modeling was performed. The investigation revealed that youngsters have moderately positive attitude towards Online Food Delivery (OFD) and it was the affective component of attitude that had the highest influence on attitude creation.
İşten Ayrılma Niyeti ve Toksik Liderliğin Etkisi
Authors: Kaptanoglu Rana Özyurt
Published: January 2020

Bireyin tedbirini alarak kendi isteği ile çalıştığı
kurumdan ayrılması veya böyle bir karara varması yorumunu getiren işten ayrılma
niyetine sahip bir iş görenin bu niyeti çoğunlukla işten ayrılma ile
sonuçlanmaktadır.  Ancak örgüt için
personelin işten ayrılması genellikle negatif bir durumdur. Çalışan devir hızı,
yetenek kaybı, ek işe alım ve eğitim masrafları bakımından bir örgüt için
gerçek bir sorun teşkil etmektedir.  Bir
örgütte çalışanların çalışmaya başlamaları kadar işten ayrılmak istemeleri de
doğal bir tutumdur. Bir çalışanın hayatının sonuna kadar aynı örgütte çalışması
gibi bir zorunluluğu yoktur. Aynı örgüte uzun süreler çalışmak, çalışan ve
örgüt bütünlüğü açısından gerekli olsa da bu gereklilik her zaman
gerçekleştirilemeyebilir. Bu bağlamda çalışmada işten ayrılma niyetinin
kapsamlı tanımı, bahsi geçen niyetin oluşma nedenleri, sonuçları, işten ayrılma
niyetinin nasıl önlenebileceği ve toksik liderliğin işten ayrılma niyetine
etkisine dair alan yazında inceleme yapılmıştır. Kurumlar için oldukça önemli
olan bu konu hakkında yapılan çalışmanın hem gerçek hayata hem de alan yazında
faydalı olacağı düşünülmektedir.
Improvement of methodical tools of the seasonal transportation irregularity assessment
Authors: Macheret D. A. , Ledney A. Yu.
Published: January 2020

Seasonal irregularity of transportation is one of the important production and economic issues for the transportation industry. This issue negatively affects operation of the railway transport as higher irregularity of transportation means limitation of the overall volume that can be realized within a year, which results in reduction of effectiveness of the industry resources use.

When assessing the seasonal irregularity of transportation by means of the method, significant error takes place due to different number of days in the months. As one of the solutions of the problem, the authors propose the improved methodical tools for assessment of the seasonal irregularity of freight transportation. First, the average daily values of the relevant volumetric indicator are used rather than the general ones; second, the load on infrastructure is determined by both the quantity of transported tons and the distance of transportation. Therefore the seasonal irregularity is determined by the loading, as well as by the freight turnover.

Improved tools of assessment of the seasonal irregularity of freight transportation presented in the article allow significantly increasing its accuracy, which will promote quality improvement of planning and analysis of the railways operation and development.
Coated Tactile Sensor Using Signal Time Delay Phenomenon
Authors: Takahashi Takayuki
Published: January 2020

Tactile sensors measure information arising from the sensor's physical interaction with its environment. There are different types, including force/torque, dynamic and thermal. Many devices require sensors to detect contact with the outside world, much like robots. Dr Takayuki Takahashi
is a researcher based in the Department of Symbiotic Systems Science, Fukushima University, Japan. He and his team have developed a tactile sensor that can be sprayed over three-dimensional shapes, called the Spray Coated Tactile Sensor (ScoTacS).
Biomimetics and precision engineering
Authors: Aoyagi Seiji
Published: January 2020

As robotics advances and ever more precise and specific actions are required, engineers are looking outside the traditional avenues for inspiration. Given the range of sophisticated actions honed in nature, it is natural that many should turn to biology for inspiration. This field of
research, where engineers attempt to create machine versions of biological features, is known as biomimetics. This is the field of Professor Seiji Aoyagi of the Department of Mechanical Engineering at Kansai University, Osaka, Japan. Rather than designing and building new structures from scratch,
biomimetics allows one to copy sophisticated designs from nature. 'Nature has acquired optimal shapes and movements during evolution, complex synthetic elements can be more easily achieved and this is where understanding of biomimetics can add much value,' outlines Aoyagi. 'Biomimetics creates
various high-level functions by imitating nature, such as elements, systems, movements, etc., of animals and plants.' However, biomimetics cannot be conducted by a single engineer, as no one person has the skills to examine and interpret the biology, transfer the biological to mechanical and
build the device. Therefore, collaboration is key. Aoyagi collaborates with a wide range of biologists, computing specialists and engineers. As one of examples, the microneedle mimicking mosquito is under development in the project he is leading, which is expected for realizing painless sampling
a small amount of blood as same as a mosquito does.
A PROTOTYPE DEVICE FOR PRODUCING FRESH WATER FROM ATMOSPHERIC AIR
Authors: Evdulov O. V. , Gabitov I. A. , Gyulmagomedov K. S. , Kobzarenko D. N. , Semilyak A. I.
Published: January 2020

Objectives.The aim of the article is to develop the design and carry out the physical and mathematical modelling of a device for producing fresh water from atmospheric air in coastal areas, as well as under the conditions of sea transport.

A Method for constructing the device for producing fresh water from atmospheric air is developed on the basis of a physical and mathematical model. Fresh water is obtained by condensation on a cold surface, which dew point is created using the natural cold of seawater with the application of the energy of moving waves for its circulation. The heating of the surface air layer adjacent to the cold surface by solar concentrators intensifies the process of the moisture condensation.

Results. Data is obtained on the quantity (mass) of fresh water produced per unit of condensation surface area (1 m2 ) for 1 hour depending on the temperature difference between the condensation surface and seawater. The influence of the characteristics of solar concentrator and liquid heat remover with seawater on the device parameters is studied.

Conclusion. It is established that the amount of the fresh water obtained from atmospheric air strongly depends on the temperature difference between the condensation surface and seawater. Thus, according to calculations, with an increase of the latter by 45 K, the mass of fresh water obtained from a condensation surface of 1 m2 in 1 hour approximately doubles to 5.8 kg.
INCREASING THE WORKING EFFICIENCY OF SOLAR POWER ABSORPTION REFRIGERATOR UNITS
Authors: Rudenko M. F. , Shipulina Yu. V. , Karimov M. Sh. , Rudenko A. M.
Published: January 2020

Objectives.The aim of the study is to develop a cyclic absorption refrigerator unit that implements technology for producing cold from solar radiation energy. Its distinctive feature comprises a highly developed solar receiving unit, consisting of two parallel-connected absorber generators whose reactors are installed in individual heat-insulated “hot box” cabinets.

Method. The geometric characteristics of the absorber generator are based on the calculations of the optical and heat energy efficiency of the device models.

Results. The physicochemical characteristics of activated carbons (AC) of various production are studied. The absorption capacity of the following working pairs is determined: AC-ammonia, AC-methylamine, AC-ethylamine. The calculated coefficients for the Dubinin-Radushkevich structural equations are obtained. An experimental solar energy refrigerator unit is tested using a working pair of AC-ammonia in an open test area. The operability of the upgraded device is proven. Exergetic coefficient dependencies are determined according to the developed software algorithm based on a simplified thermodynamic cycle. The areas of possible application and use of solar power refrigerator units with the studied working pairs are determined.

Conclusion. The increased unit efficiency consists in the optimal layout of all elements of the absorber generator, including the reactor, two flat mirror concentrators, a thermal substrate, a reduced internal air space volume, a double-glazed window made of two sheets of glass and a calculated thickness of heat-insulating Ripor foamed polyurethane.
Hypothermic Oxygenated Perfusion Versus Static Cold Storage for Expanded Criteria Donors in Liver and Kidney Transplantation: Protocol for a Single-Center Randomized Controlled Trial
Authors: Ravaioli Matteo , Maroni Lorenzo , Angeletti Andrea , Fallani Guido , De Pace Vanessa , Germinario Giuliana , Odaldi Federica , Corradetti Valeria , Caraceni Paolo , Baldassarre Maurizio , Vasuri Francesco , D'Errico Antonia , Sangiorgi Gabriela , Siniscalchi Antonio , Morelli Maria Cristina , Rossetto Anna , Ranieri Vito Marco , Cescon Matteo , Del Gaudio Massimo , Zanfi Chiara , Bertuzzo Valentina , Comai Giorgia , La Manna Gaetano
Published: January 2020

Background

Extended criteria donors (ECD) are widely utilized due to organ shortage, but they may increase the risk of graft dysfunction and poorer outcomes. Hypothermic oxygenated perfusion (HOPE) is a recent organ preservation strategy for marginal kidney and liver grafts, allowing a redirect from anaerobic metabolism to aerobic metabolism under hypothermic conditions and protecting grafts from oxidative species–related damage. These mechanisms may improve graft function and survival.

Objective

With this study, we will evaluate the benefit of end-ischemic HOPE on ECD grafts for livers and kidneys as compared to static cold storage (SCS). The aim of the study is to demonstrate the ability of HOPE to improve graft function and postoperative outcomes of ECD kidney and liver recipients.

Methods

This is an open-label, single-center randomized clinical trial with the aim of comparing HOPE with SCS in ECD kidney and liver transplantation. In the study protocol, which has been approved by the ethics committee, 220 patients (110 liver recipients and 110 kidney recipients) will be enrolled. Livers and kidneys assigned to the HOPE group undergo machine perfusion with cold Belzer solution (4-10°C) and continuous oxygenation (partial pressure of oxygen of 500-600 mm Hg). In the control group, livers and kidneys undergoing SCS are steeped in Celsior solution and stored on ice. Using the same perfusion machine for both liver and kidney grafts, organs are perfused from the start of the back-table procedure until implantation, without increasing the cold ischemia time. For each group, we will evaluate clinical outcomes, graft function tests, histologic findings, perfusate, and the number of allocated organs. Publication of the results is expected to begin in 2021.

Results

Dynamic preservation methods for organs from high-risk donors should improve graft dysfunction after transplantation. To date, we have recruited 108 participants. The study is ongoing, and recruitment of participants will continue until January 2020.

Conclusions

The proposed preservation method should improve ECD graft function and consequently the postoperative patient outcomes.

Trial Registration

ClinicalTrials.gov NCT03837197; https://clinicaltrials.gov/ct2/show/NCT03837197 ; Archived by WebCite® at http://www.webcitation.org/76fSutT3R

International Registered Report Identifier (IRRID)

DERR1-10.2196/13922
Possibilities, Problems, and Perspectives of Data Collection by Mobile Apps in Longitudinal Epidemiological Studies: Scoping Review (Preprint)
Authors: Fischer Florian , Kleen Sina
Published: January 2020

BACKGROUND

The broad availability of smartphones and the number of health apps in app stores have risen in recent years. Health apps have benefits for individuals (eg, the ability to monitor one’s health) as well as for researchers (eg, the ability to collect data in population-based, clinical, and observational studies). Although the number of health apps on the global app market is huge and the associated potential seems to be great, app-based questionnaires for collecting patient-related data have not played an important role in epidemiological studies so far.

OBJECTIVE

This study aims to provide an overview of studies that have collected patient data using an app-based approach, with a particular focus on longitudinal studies. This literature review describes the current extent to which smartphones have been used for collecting (patient) data for research purposes, and the potential benefits and challenges associated with this approach.

METHODS

We conducted a scoping review of studies that used data collection via apps. PubMed was used to identify studies describing the use of smartphone app questionnaires for collecting data over time. Overall, 17 articles were included in the summary.

RESULTS

Based on the results of this scoping review, there are only a few studies that integrate smartphone apps into data-collection approaches. Studies dealing with the collection of health-related data via smartphone apps have mainly been developed with regard to psychosomatic, neurodegenerative, respiratory, and cardiovascular diseases, as well as malign neoplasm. Among the identified studies, the duration of data collection ranged from 4 weeks to 12 months, and the participants’ mean ages ranged from 7 to 69 years.
Potential can be seen for real-time information transfer, fast data synchronization (which saves time and increases effectivity), and the possibility of tracking responses longitudinally. Furthermore, smartphone-based data-collection techniques might prevent biases, such as reminder bias or mistakes occurring during manual data transfers. In chronic diseases, real-time communication with physicians and early detection of symptoms enables rapid modifications in disease management.

CONCLUSIONS

The results indicate that using mobile technologies can help to overcome challenges linked with data collection in epidemiological research. However, further feasibility studies need to be conducted in the near future to test the applicability and acceptance of these mobile apps for epidemiological research in various subpopulations.
Evaluation of Volume of News Reporting and Opioid-Related Deaths in the United States: Comparative Analysis Study of Geographic and Socioeconomic Differences (Preprint)
Authors: Hswen Yulin , Zhang Amanda , Freifeld Clark , Brownstein John S
Published: January 2020

BACKGROUND

News media coverage is a powerful influence on public attitude and government action. The digitization of news media covering the current opioid epidemic has changed the landscape of coverage and may have implications for how to effectively respond to the opioid crisis.

OBJECTIVE

This study aims to characterize the relationship between volume of online opioid news reporting and opioid-related deaths in the United States and how these measures differ across geographic and socioeconomic county-level factors.

METHODS

Online news reports from February 2018 to April 2019 on opioid-related events in the United States were extracted from Google News. News data were aggregated at the county level and compared against opioid-related death counts. Ordinary least squares regression was used to model opioid-related death rate and opioid news coverage with the inclusion of socioeconomic and geographic explanatory variables.

RESULTS

A total of 35,758 relevant news reports were collected representing 1789 counties. Regression analysis revealed that opioid-related death rate was positively associated with news reporting. However, opioid-related death rate and news reporting volume showed opposite correlations with educational attainment and rurality. When controlling for variation in death rate, counties in the Northeast were overrepresented by news coverage.

CONCLUSIONS

Our results suggest that regional variation in the volume of opioid-related news reporting does not reflect regional variation in opioid-related death rate. Differences in the amount of media attention may influence perceptions of the severity of opioid epidemic. Future studies should investigate the influence of media reporting on public support and action on opioid issues.
Delivering Anger Management Treatment through a Web-Based Intervention Supplemented with Brief Coaching: A Pilot Study (Preprint)
Authors: Mackintosh Maggi
Published: January 2020

BACKGROUND

Dysregulated anger as part of post-traumatic stress disorder (PTSD) can disrupt interpersonal functioning and negatively impact mental and physical health. However, many individuals are not able or willing to access clinic-based services. Self-management interventions, such as web-based programs, can reach those who need treatment but are not obtaining care from clinics.

OBJECTIVE

This paper describes a pilot study investigating a self-directed web-based anger management intervention combined with brief clinician-level support for veterans.

METHODS

The Anger and Irritability Management Skills (AIMS) course is an eight-session cognitive-behavioral program. This intervention was augmented with weekly phone-based coaching to enhance treatment engagement. Six males living on the Hawaiian Islands enrolled in the study.

RESULTS

Results broadly supported the AIMS intervention's feasibility, efficacy, and usability with briefing coaching. Four of the six (67%) participants completed the study. Three of these four (75%) demonstrated statistically significant reductions in anger symptoms. AIMS received high usability ratings. Participants reported phone coaching to help complete the intervention and learn anger management skills. Individuals who terminated treatment early had higher anger and mental health scores at baseline than those who completed the intervention.

CONCLUSIONS

The AIMS intervention with brief clinician-level coaching performed well across several indicators, including feasibility, usability, treatment engagement, and initial efficacy. Results highlight the utility of self-management interventions along the continuum of care. Further research is warranted to investigate the effectiveness of AIMS and to identify best practices for implementing support services to maintain treatment engagement and skills development.

CLINICALTRIAL
A COMPARATIVE IN VITRO ANTI-BIOFILM EFFICACY OF PHYTOSYNTHESIZED IRON AND SILVER NANOPARTICLES
Authors: BRINDHA S. GOKUL , HANSIYA V. S. , MAHESWARI P. UMA , GEETHA N.
Published: January 2020

Objective: The objective of the work was to evaluate the efficacy of anti-biofilm activity of green synthesized silver and iron oxide nanoparticles comparatively.

Methods: Nanoparticles were synthesized using a rapid, single-step and completely by a green biosynthetic method employing aqueous leaf extracts of Moringa oleifera Lam. The synthesized nanoparticles were characterized by UV-Vis spectrophotometry and X-Ray Diffraction. Bacterial strains used in this study included Staphylococcus epidermidis and Pseudomonas aeruginosa. The biofilm reduction was evaluated through ring test using crystal violet as a staining agent.

Results: Colour change was observed after half an hour, which indicated the formation of silver and iron nanoparticles. Synthesis of nanoparticles was confirmed by UV and XRD. The anti-biofilm forming ability of AgNPs and FeNPs were compared with standard antibiotic. It was found that FeNPs showed more biofilm destruction ability (58%) for S. compared to P. aeruginosa (50%) and standard (30%). Whereas, AgNPs displayed significant biofilm destruction ability (78%) for P. aeruginosa compared to S. epidermidis (43%) and standard (34%).

Conclusion: Based on the results obtained in this investigation, it is concluded that FeNPs have anti-biofilm activity against S. epidermidis whereas AgNPs have anti-biofilm activity against P. aeruginosa.
ZIPRASIDONE HYDROCHLORIDE LOADED NANOSTRUCTURED LIPID CARRIERS (NLCS) FOR INTRANASAL DELIVERY: OPTIMIZATION AND IN VIVO STUDIES
Authors: SIVADASU PRAVEEN , D. V. GOWDA , H. SIDDARAMAIAH , S. HEMALATHA
Published: January 2020

Objective: The present study was an attempt to systemically deliver the most desirable schizophrenia drug, ziprasidone hydrochloride (ZRS) via the intranasal route using nanostructured lipid carrier (NLC) approach.

Methods: The desired ZRS loaded NLCs were developed using central composite statistical design and the developed formulation was monitored for improving ZRS bioavailability and their brain targeting efficacy.

Results: Pharmacokinetic studies revealed a 10 fold increase (ZRS blood-brain ratio) for NLCs administered through nasal route (in comparison to intravenous route). Similarly, the concentration of ZRS (in the brain) delivered via nasal route exhibits 4 fold increment at all-time points.

Conclusion: Therefore, the obtained results suggest a potential nose to brain transport of loaded ZRS by effective bypassing of the Blood-Brain Barrier (BBB).
IMPROVEMENT OF SIMVASTATIN DISSOLUTION RATE USING DERIVATIVE NON-COVALENT APPROACH BY SOLVENT DROP GRINDING METHOD
Authors: SOPYAN IYAN , SYAH INSAN SUNAN KURNIWAN , NURHAYTI DESI , BUDIMAN ARIF
Published: January 2020

Objective: This study aimed to enhance the solubility of simvastatin using noncovalent derivatives (NCDs) with oxalic acid (OA), fumaric acid (AF), and nicotinamide (NK) as conformers.

Methods: NCDs were prepared using by a solvent drop grinding (SDG). The NCDs formed were evaluated for saturated solubility test, NCDs with the highest saturation solubility were then characterized by Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimeter (DSC), powder x-ray diffractometry (PXRD) and the particulate dissolution using type II of USP test.

Results: SV-OA NCDs showed the highest solubility; thus NCDS of SV-OA were characterized by X-ray diffraction showing a new peak at 2ϴ = 28.96 °C and differential scanning calorimeter showed a change of endothermic peak from 134.3 °C to 69 °C. Infrared spectroscopy indicated that there were no functional group changes from simvastatin, while the dissolution rate increased from 68.22% to 76.08%.

Conclusion: SV-OA NCDs show an increased profile of solubility and dissolution compared to pure simvastatin.
SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF CUO NANOPARTICLES
Authors: KUMAR PARDEEP , NENE AJINKYA GIRISH , PUNIA SANDEEP , KUMAR MANOJ , ABBAS ZAHOOR , THAKRAL FALAK , TULI HARDEEP SINGH
Published: January 2020

Objective: The present study was done to see the effect of biologically synthesized CuO-NPs (Copperoxide nanoparticles) on the growth of bacterial strains.

Methods: Physico-chemical characterization of CuO-NPs was done by UV-Vis-spectrophotometer, XRD, FE-SEM, and EDS. The disc plate diffusion assay was used to evaluate the anti-bacterial effect of CuNPs.

Results: This study has shown a promising anti-bacterial activity of biosynthesized CuO-NPs at different concentrations ranging from 10 to 100 µg/ml against Escherichia coli and Staphylococcus aureus bacteria.

Conclusion: Nanoparticles (NPs) are small size particles between range 1 to 100 nm which expand their physical and chemical properties due to high surface area. The present study reveals that there may be possible utilization of biosynthesized CuO NPs for the treatment of bacterial infectious disease in near future.
Sistema de producción multi-línea optimizado por PSO
Authors: Quezada Aguilar Victor , Seck Tuoh Mora Juan Carlos , Quezada Quezada José Carlos , Cuatepotzo Bravo Arturo
Published: January 2020

La competitividad en el sector industrial nacional e internacional exige variabilidad de productos donde la flexibilidad de los sistemas productivos es el eje principal, sin embargo el manejo inadecuado de los recursos disminuye el factor de competencia en los mercados. En el documento se considera el problema de asignación de órdenes de producción en un sistema flexible que tiene 4 líneas productivas donde cada una cuenta hasta con 6 estaciones de trabajo. La producción es de 10 lotes donde cada uno de ellos contiene hasta 5 productos diferentes. El objetivo es encontrar la asignación de lotes para su procesamiento a las líneas de producción, que optimicen el tiempo total de procesamiento así como el tiempo total de demora. Para lograr el objetivo se evalúan soluciones en el simulador del sistema productivo donde la optimización de las funciones objetivo le corresponden al algoritmo PSO (Particle Swarm Optimization). La optimización se realiza para cada función objetivo y para ambas considerando pesos ponderados. Los resultados muestran correlación en los valores de las funciones objetivo, sin embargo la solución del óptimo de la función objetivo 1 no lo es para la función objetivo 2 y viceversa. Una limitante en el proceso de optimización es la aleatoriedad que existe en el sistema de producción, lo que implica tener valores diferentes para una misma solución sin embargo el proceso de optimización mantiene la solución óptima.
RELEVANSI NILAI INKREMENTAL ARUS KAS OPERASI DAN LABA (EARNING AFTER TAX) TERHADAP HARGA SAHAM (Study Kasus di Perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) periode 2015-2017)
Authors: Zuhairoh Fatimatus , Aji Tony Seno , Ardiana Meta
Published: January 2020

The aim of the study was to prove empirically the effect of net income after taxand operating cash flow on stock prices in the BEI-listed manufacturing companies for the period 2015-2017 and to see whether there was an incremental relevance given by the two independent variables to the dependent variable. The object of the research was carried out on manufacturing companies listed on the IDX for the period 2015-2017. The sample selection method used was purposive sampling and the selected sample amounted to 77 manufacturing companies multiplied by 3 years to number 231 company data. This study uses secondary data and is assisted by the SPSS version 16.0 statistical test. The results of the study show that cash flow from operations have incremental value relevance to closing price stock, as like the cash flow from operations, Earnings after tax have incremental value relevance to closing price stock too. Conclusions from the research show that both of cash flow from operations dan earning after tax have incremental value relevance to closing price stock.   Keywords:Value Relevance, Incremental Value, Operating Cash Flow, Earning After Tax, Stock Price.
Modifikasi enkripsi dan dekripsi AES menggunakan polybius chiper dalam pengamanan data
Authors: Arifianto Sofyan , Permatasari Shinta , Aminudin Aminudin
Published: January 2020

Data is a file that can be confidential so it requires a data security process to maintain confidentiality.  Kripotgrrafi is a data security process that can be used based on the use of algorithms, one of which is AES.  AES is a modern algorithm that can be modified to improve confusion and diffusion in cryptography.  AES combination can be done using Polybius which has cryptographic diffusion properties.  This study modified the AES using 6x6 and 10x10 polybius matrices that were performed on plaintext and plaintext and keys.  Analysis was carried out based on the highest bit change rate found in modification II in the plaintext and 6x6 matrix keys, which amounted to 51.8% using the avalanche effect test.  The results of the AE compared to the expected results using chi square with the modified AES results can increase the AE by 5% with the real level is 0,05 and the degree of freedom is 4 . Execution time was tested in this study with the results of the AES modification time longer than the standard AES because the complexity of the algorithm affects both encryption and decryption time.Abstract Data is a file that can be confidential so it requires a data security process to maintain confidentiality.  Kripotgrrafi is a data security process that can be used based on the use of algorithms, one of which is AES.  AES is a modern algorithm that can be modified to improve confusion and diffusion in cryptography.  AES combination can be done using Polybius which has cryptographic diffusion properties.  This study modified the AES using 6x6 and 10x10 polybius matrices that were performed on plaintext and plaintext and keys.  Analysis was carried out based on the highest bit change rate found in modification II in the plaintext and 6x6 matrix keys, which amounted to 51.8% using the avalanche effect test.  The results of the AE compared to the expected results using chi square with the modified AES results can increase the AE by 5% with the real level is 0,05 and the degree of freedom is 4 . Execution time was tested in this study with the results of the AES modification time longer than the standard AES because the complexity of the algorithm affects both encryption and decryption time.
Parents’ Perception of Child Weight Status, Risk Factors and Health Concern of Childhood Obesity: A Systematic Review
Authors: Mawia M. Beshti  , Tin Tin Su  , Nik Daliana Nik Farid  , Meram Azzani
Published: January 2020

The increased prevalence of childhood obesity is becoming a public health concern as it is related to numerous health implications. Parental  perception  of child’s  weight  status  is an important  factor  for  reducing  childhood  obesity  burden.  Parental  perception  of the  risk factors and health outcomes of obesity are important in prevention and management  of childhood obesity. However, previous reviews focused mainly on parental perceptions  about healthy behaviors  to reduce the burden of childhood  obesity. Thus, this systematic  review was carried out to investigate parental perceptions of their child weight status as well as risk factors and health concern of childhood obesity. A systematic review  was  conducted  and  was  reported  in accordance  with  PRISMA  statement  on studies  between  2012  and  2017  through  a variety  of database like CINAHL, PubMed, Science Direct, Scopus and Cochrane Library.  However, out of 2,334 articles identified, only 35 studies were included, which originate  mostly from high-income  countries.  The results revealed  that parents’ misperception  rate of their children’s  weight varies  from  9.6%  to  90%,  while  parents  perceptive      that  only  genetic  factors,  non-vegetable-consumption  or  low  physical  activity  and environmental  factors are the key risk factors of childhood  obesity. Hence, parents’ of obese children estimate their children to be at risk at having hypertension,  heart disease, depression,  and diabetes. In conclusion,  parents have difficulty in correctly perceiving  the obesity status of their  children.  Health  care  workers  should  be aware  of the parents’  wrong  perception  of their  children’s  weight  status.  The result  of this review  may be used to develop  an effective  intervention  programs  aimed  at reducing  the burden  of childhood  obesity  which  focus  on the parental perception of the risk factors contributing to childhood obesity.
Adherence to Medications among Outpatient Adults with Multiple Sclerosis in Medina Province in Ksa (Cross-Sectional Study)
Authors: Salma Moteb T Al-Mutairi  , Hatim Muhammad H Alshalahi  , Sara Moteb T Al-Mutairi  , Abid M Kareem
Published: January 2020

Multiple sclerosis  (MS) is a chronic, inflammatory,  progressive,  demyelinating  disease of the central nervous system.  Treatment  for  MS  involves  long-term  disease-modifying  therapies  (DMTs).  Medication  adherence  in  chronic diseases like MS plays an important role in predicting long-term outcomes. This is a cross-sectional,  survey-based  study was done to assess adherence to medications among adults suffering from MS in Medina Province, Saudi Arabia. The study sample  included  90patients  diagnosed  with  multiple  sclerosis.  These  databases  contain  information  about  disease presentation, drug prescription, vital status, residency, and role of contact to patient. All the collected data were analyzed by an SPSS program, version 20, and p value < 0.05 was considered  significant. A response rate among the MS patients was 97.78%, and their mean age was 36.13±9.58. Most of the participants were above 35 years (55%) and were females. About 37.8% of patients was considered  to be adherent to the drugs. The mean total score of BMQ Specific-Necessity was 3.25±0.70  and about 63.4% total score=3  and the mean total score of BMQ Specific-Concerns  was (3.34±0.703). About  84.4%  total  score=3.  The  mean  total  score  of  BMQ  General  was  3.2727±0.31,  and  about  81.1%  had  a  total score=3. The mean total score of compliance was 3.2023±0.393.We concluded that many factors affected the patient's adherence to the drug rather than of being dependence  to the drugs as worrying about side effects and the cost of the drug.
Isolation, Screening and Identification of Cellulolytic Streptomyces corchorusii (Mn244066) From Soil Sample of Visakhapatnam
Authors: L.Sujatha  , K.P.J. Hemalatha
Published: January 2020

Fifty one isolates of cellulolytic bacteria were isolated from cow dung and two soil samples were obtained from Kambalakonda Wildlife Sanctuary and RCD Biodiversity Park in Visakhapatnam, Andhra Pradesh by Enrichment method in basal salt medium with cellulose as substrate for degradation. The cellulolytic activity of the isolated bacteria was determined by the diameter of the zone of hydrolysis by Gram’s iodine dye staining method. After primary screening, a total of fifty one isolates showed cellulolytic activity. Out of fifty one strains of cellulolytic bacteria, twenty three isolates from Kambalakonda Wildlife Sanctuary, seventeen isolates from RCD Biodiversity Park and Eleven isolates from cow dung sample obtained from cattle ranch, Visakhapatnam showed cellulase activity. Seven strains showed maximum hydrolytic value greater than 4.0 cm, nineteen strains showed average hydrolytic value between 3.0 and 3.9 cm and twenty one strains showed minimum hydrolytic value between 1.5 and2.9 cm. The potential isolates were obtained from Kambalakonda Wildlife Sanctuary and RCD Biodiversity Park than cow dung sample. The 13 C strain exhibited maximum hydrolytic value of 5.6 cm which was designated as KKV1. The strain KKVI was identified as Streptomyces corchorusii (MN244066) by morphological, cultural, biochemical and 16S rRNA sequence. The CMCase and FPase activity of the crude sample were examined by DNS method and found to be 0.21 U/ml and 0.041 U/ml respectively and the specific activity was 4.38 U/mg proteins and 0.86 U/mg proteins respectively. The present study emphasizes that the Streptomyces corchorusii have a higher cellulase activity and the soils of bio reserves have a lot of scope for isolating high cellulolytic bacteria which can be exploited for different industrial purposes.
Increasing The Role As Well As Communities In The Construction of Forest Fire Through The Strengthening of Individual Institutions In Muaro Jambi District
Authors: Syarif Afif , Fitria Fitria
Published: January 2020

Disasters of forest and land fires accompanied by smoke disasters that hit Jambi Province especially in Muaro Jambi Regency have an impact on the health, environment and economy of the people both in Indonesia and in neighboring countries, Malaysia and Singapore. This legal counseling aims to describe and analyze the strengthening of customary institutions in the prevention and control of forest and land fires in Muaro Jambi District. This legal extension uses a type of descriptive approach with a qualitative approach. The focus of this legal counseling is the strengthening of indigenous peoples' institutions in the prevention and control of forest and land fires. The expected outcome of this legal counseling is the strengthening of indigenous peoples' institutions in the prevention and control of forest and land fires that have not been effective. The advice given is in fire control should be at the stage of prevention of preventive and repressive measures in the enforcement of environmental law against forest and land burning in Muaro Jambi district.