bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrospective observational study of chloral hydrate use in mechanically-ventilated pediatric intensive care unit (PICU) patients 2012–2017
Authors: Ettinger Nicholas A. , Kiskaddon Amy , McNeely Lindsay , Craycraft Justin , Rogers Amber , Achuff Barbara-Jo , Guffey Danielle , Musick Matthew
Published: May 2023

Introduction: Chloral hydrate (CH) has long been utilized as a pediatric procedural sedation agent. However, very little is published describing CH use in a pediatric intensive care unit (PICU) setting. The aim of this retrospective observational cohort study was to investigate and describe the use of CH in mechanically-ventilated, critically ill children at a large pediatric tertiary referral hospital.

Methods: Data were extracted from the hospital electronic medical record and a locally maintained registry of all children admitted to the PICU between 2012 and 2017. Patients admitted to the cardiovascular ICU were not included in this review. The clinical and pharmacy data for 3806 consecutive PICU admissions of mechanically-ventilated, critically ill children were examined.

Results: 283 admissions received CH during their first ICU stay. CH-exposed children were younger (16 months vs. 35 months, p < 0.001), the median total dose of CH (indexed to duration of ventilation) was 11 mg/kg/day, the median time to first CH dose was 3 days and more CH doses were administered at night (1112 vs. 958, p < 0.001). We constructed a propensity score to adjust for the differences in patients with and without CH exposure using logistic regression including variables of age, sex, diagnosis, and PRISM3 score. After adjustment, the median length of mechanical ventilation was 5 days longer in the CH-exposed group (95% Confidence Interval [CI] 4–6) compared to unexposed CH patients. Similarly, the median length of ICU duration was 9.4 days longer (95% CI 7.1–11.6) and median length of hospital admission duration was 13.2 days longer (95% CI 7.8–18.6) in CH-exposed patients compared to CH-non-exposed. After adjustment, CH-exposed patients had a 9% higher median exposure to HFOV (95% CI 3.9–14.6), but did not have higher median exposures to new tracheostomy (95% CI −0.4–2.2) or ECMO (95% CI −0.2–5.0).

Discussion: As part of an extended sedation regimen in mechanically-ventilated and critically ill children, CH is associated with somewhat higher complexity of illness and longer ICU durations.
ED90 of epidural esketamine with 0.075% ropivacaine for labor analgesia in nulliparous parturients: a prospective, randomized and dose-finding study
Authors: Lou Siwen , Du Qiang , Yu Liwei , Wang Qingfu , Yu Jing , Mei Zhong
Published: May 2023

Background: Because it has been reported that racemic ketamine had a local anesthetic-sparing effect when used for epidural analgesia this would suggest the likelihood of a potential advantage (less pruritus) over opioid drugs. Esketamine has greater analgesic efficacy than racemic ketamine, but the optimum dosage regimen for epidural use is undetermined. The aim of this study was to determine the ED90 of epidural esketamine when coadministered with 0.075% ropivacaine for labor analgesia.

Methods: A total of 65 laboring nulliparous patients were enrolled in this study from 16 March 2022 to 15 October 2022. The patients were randomly assigned to receive 0, 0.25, 0.5, 0.75 or 1.0 mg/mL esketamine with 0.075% ropivacaine epidurally. An effective response to the epidural loading dose was defined as numerical rating scale pain score ≤3 at 30 min after the end of the epidural loading dose (10 mL of the ropivacaine 0.075% solution with the added esketamine). The ED90 of epidural esketamine coadministered with 0.075% ropivacaine with 95% confidence intervals for labor analgesia was determined using probit regression. Secondary outcomes and side effects were recorded.

Results: The estimated value of ED90 with 95% CIs for epidural esketamine with 0.075% ropivacaine was 0.983 (0.704–2.468) mg/mL. The characteristics of sensory and motor block, consumption of ropivacaine per hour, duration of first or second stage, Apgar scores did not differ among the five groups. The incidence of mild dizziness in Group esketamine 1.0 mg/mL was significantly higher than that in other groups (p < 0.05). No statistical differences were found in other side effects among groups.

Conclusion: The ED90 value of epidural esketamine coadministered with 0.075% ropivacaine for labor analgesia in nulliparous parturients was about 1.0 mg/mL. Furthermore, our results suggested that epidural esketamine would cause dose-dependent mild dizziness especially at doses up to 1.0 mg/mL. As a single epidural additive, esketamine may not be suitable for labor analgesia. Future studies may investigate the appropriate dosage of esketamine at slightly higher concentrations of local anesthetics or larger initial volume of analgesia, or explore other potential advantages of esketamine.

Clinical Trial Registration: (https://www.chictr.org.cn/bin/project/edit?pid=159764), identifier (ChiCTR2200057662).
Basic and clinical study of efficacy and adverse effects of flumatinib in Ph+ ALL
Authors: Wang Jun , Wu Jiafei , Wang Yijing , Zheng Boyue , Wang Yu , Jiang Chuanyan , Zou Mengying , Li Hui
Published: May 2023

Objective: To investigate the efficacy and safety of chemotherapy in treating Ph+ ALL based on flumatinib.

Methods: The clinical data of 29 patients with Ph+ ALL receiving flumatinib-based chemotherapy in Sichuan Provincial People’s Hospital from January 2020 to January 2023 were collected for analysis, with the concentrations of TKI in the peripheral blood, bone marrow, and cerebrospinal fluid of some patients monitored, Cytological experiments on SUP-B15 were conducted in a Ph+ ALL cell line.

Results: A total of 29 patients were enrolled, showing the induced CR, 3-month CR, and 6-month CR rates of 96.3%, 87.5%, and 86.7%, respectively after flumatinib-based chemotherapy. The negative conversion ratio of MRD was 82.6%, 91.3%, and 95.6% in 1, 2, and 3 months after treatment, respectively, with 4.3% of patients failing the conversion in 3 months after treatment. The rates of MMR were 73.9%, 87.5%, and 93.3% in 1, 3, and 6 months after treatment, and CMR of 52.2%, 62.5%, and 73.3%, respectively. Among the 29 patients, 11 (37.9%) received transplant and the continuous flumatinib for 1 year after transplantation. The deep remission was maintained in all patients up to the time of follow-up, with the median follow-up of 12 months (1–33 months), progression-free survival (PFS) of 11 months (1–33 months), and median overall survival (OS) of 12 months (1–33 months). The adverse reactions mainly referred to myelosuppression, liver insufficiency and infection that were generally tolerable. In terms of blood concentration, the concentration of flumatinib was ordered as bone marrow > serum > cerebrospinal fluid in Ph+ ALL bone marrow. In contrast, the concentration of dasatinib and imatinib was ordered as serum > bone marrow > cerebrospinal fluid. At the same time, flumatinib has a high probability to cross the blood-brain barrier, while the concentration of cerebrospinal fluid in the patients using Dasatinib was lower compared to the lower limit of detection in this study. Compared with Imatinib and Dasatinib, flumatinib exerted the most potent inhibitory effect on Ph+ ALL cell lines according to pharmacodynamic analysis of SUP-B15 cells.

Conclusion: Flumatinib combined with chemotherapy could achieve good efficacy and safety in treating Ph+ ALL, with flumatinib in a high probability of crossing the blood-brain barrier. Flumatinib could be a superior choice to Dasatinib and Imatinib in cell experiments.
Flexible terahertz optics: light beam profile engineering via C-shaped metallic metasurface
Authors: Ivaškevičiūtė-Povilauskienė Rusnė , Čižas Vladislovas , Nacius Ernestas , Grigelionis Ignas , Redeckas Karolis , Bernatonis Matas , Orlov Sergej , Valušis Gintaras , Minkevičius Linas
Published: May 2023

The potential of terahertz (THz) imaging implementation in a large variety of applications requires compact, reliable, and relatively low-cost solutions in systems constituents. Here we focus on the development of passive optical elements and demonstrate flexible and reliable THz beam profile engineering for imaging aims via mechanical bending of a stainless steel-based C-shaped metasurface. The designed and laser-ablation technology fabricated metasurface provides compact THz focusing and enables THz light engineering as well as polarization control ability in THz imaging. Focusing, light profile engineering, and polarization control performances of the metasurfaces with different focal distances and C-shape designs are presented. Experimental data are well supported by simulations, using Finite Difference Time Domain (FDTD) method. THz images of different objects at ∼94 GHz using InP Gunn diode, bow-tie sensors, and exclusively metasurfaces-based optics are exposed. Further routes in the development of low-cost multicolor and polarization-sensitive THz imaging are discussed.
Exercise and COVID-19: exercise intensity reassures immunological benefits of post-COVID-19 condition
Authors: Thirupathi Anand , Yong Wang , Oflaz Ofcan , Agascioglu Eda , Gu Yaodong
Published: May 2023

Any form of physical activity, including exercise, has various benefits at the physiological (improving cardiac and respiratory functions, increasing skeletal muscle mass, and maintaining homeostasis) and psychological levels (improving cognitive function, reducing anxiety and depression) which help to combat any type of infection. In contrast, the infectivity ratio could reduce the physical activity of an individual, such as performing a habitual exercise. Adaptation to different exercise strategies including intensity and duration may better increase physical performance and improve the symptoms. For example, low to moderate intensity perhaps fails to induce this adaptive process, while high-intensity of exercise compromises immune health. This can aggravate the infection rate (Open window theory). However, high intensity with a shorter time produces various morphological alterations in the primary organs including the lungs and heart, which facilitate life support in COVID-19 patients. However, less information about exercise protocols failed to assure the benefits of exercise to COVID-19 patients, particularly post-COVID-19 conditions. Therefore, this review will answer how exercise intensity is crucial to reassure the exercise benefits for promoting safe participation before infection and post-COVID-19 conditions.
Resistance monitoring and mechanism in the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae) for chlorantraniliprole from Sichuan Province, China
Authors: Chen Hui-Lin , Hasnain Ali , Cheng Qing-Hua , Xia Li-Juan , Cai Yu-Hao , Hu Rong , Gong Chang-Wei , Liu Xue-Mei , Pu Jian , Zhang Lei , Wang Xue-Gui
Published: May 2023

The fall armyworm, Spodoptera frugiperda (Noctuidae: Lepidoptera), is a wide-reaching notorious insect pest of important cereal crops, which has developed resistance to multiple classes of insecticides. It invaded the Sichuan Province of China in 2019. In this study, we performed resistance monitoring of insecticides for 11 field-collected populations from Sichuan, and all the populations were susceptible to emamectin benzoate and chlorpyrifos. The variations in resistance level to indoxacarb (resistance ratio (RR), 9.23–45.53-fold), spinetoram (RR, 4.32–18.05-fold), and chlorantraniliprole (RR, 2.02–10.39-fold) were observed among these populations. To investigate the resistance mechanism of chlorantraniliprole, synergism tests were performed and showed that piperonyl butoxide had a slight synergistic effect on chlorantraniliprole for the QJ-20 population (1.43-fold) in moderate resistance (RR, 10.39-fold) compared with the treatment group without synergist. Furthermore, the expression scanning for resistance-related genes showed that five P450 genes (CYP6AE43, CYP321A8, CYP305A1, CYP49A1, and CYP306A1) and the ryanodine receptor gene (Ryr, chlorantraniliprole target) were overexpressed in the QJ-20 population. These results indicated that the fall armyworm in Sichuan has exhibited diverse susceptibilities to several classes of insecticides, and the overexpression of Ryr and several P450 genes may contribute to the development of resistance in S. frugiperda to chlorantraniliprole.
Towards the self and away from the others: evidence for self-prioritization observed in an approach avoidance task
Authors: Roy Neelabja , Karnick Harish , Verma Ark
Published: May 2023

Processing advantages arising from self-association have been documented across various stimuli and paradigms. However, the implications of “self-association” for affective and social behavior have been scarcely investigated. The approach-avoidance task (AAT) offers an opportunity to investigate whether the privileged status of the “self” may also translate into differential evaluative attitudes toward the “self” in comparison to “others”. In the current work, we first established shape-label associations using the associative-learning paradigm, and then asked the participants to engage in an approach-avoidance task to test whether attitudinal differences induced on the account of self-association lead to participants having different approach-avoidance tendencies toward the “self-related” stimuli relative to the “other-related” stimuli. We found that our participants responded with faster approach and slower avoidance tendencies for shapes associated with the “self” and slower approach and faster avoidance tendencies for the shapes associated with the “stranger.” These results imply that “self-association” may lead to positive action tendencies toward “self-associated” stimuli, and at the same time lead to neutral or negative attitudes toward stimuli not related to the “self”. Further, as the participants responded to self-associated vs. other-associated stimuli cohorts, these results may also have implications for the modulation of social group-behaviors in favor of those like the self and against those in contrast to the self-group.
Prevalence of neuromyths among psychology students: small differences to pre-service teachers
Authors: Novak-Geiger Verena
Published: May 2023

Neuroscience will possibly aid the educational practice but neuromyths are prevalent worldwide. Certain misconceptions about learning, memory and the brain are prevalent in different groups and hard to dispel. Bridging the gap might be too far. However, Psychology may serve as a bridge between these distant fields. The present study examined neuromyth endorsement in psychology students. An online questionnaire based on 20 neuromyths and 20 neurofacts was used. Additionally, neuroscience exposure at university and media exposure was assessed. The sample consisted of psychology students (N = 116) in Austria and was compared to a teacher-training sample. The different groups were compared using Signal Detection Theory, Chi-square test, non-parametric correlation analyses, and independent sample t-test. No correlation between neuroscience exposure at university and leisure time for psychology students at the beginning of their studies could be found. Here, the same misconceptions were among the most prevalent—compared to the teacher-training students sample. Results show significant difference between the groups on discrimination ability and response bias. Although psychology students share the same most prevalent misconceptions, they differ significantly in their amount of agreement. The reported study reveals a better discernment ability and lower response bias on neuromyths in the Psychology students’ sample. On the individual item level, they performed better at rejecting some neuromyths than pre-service teachers. In conclusion, some neuroscience and pedagogical psychology training improves the ability to discriminate between true and false statements. Therefore, directly addressing these misconceptions within the study program—Teacher Training and Psychology—could reduce neuromyth endorsement.
Distress and eustress: an analysis of the stress experiences of offshore international students
Authors: Gong Wuwei , Geertshuis Susan A.
Published: May 2023

Introduction

The popularity of online learning provides higher education institutions with opportunities to deliver remote educational programs for international students who remain in their home countries but enroll in overseas universities. Yet the voices of offshore international students (OISs) have been rarely heard. This study focuses on the stress experiences of OISs, aiming to investigate the perception of stressors, specific responses, and stress management strategies pertaining to distress (negative stress) and eustress (positive stress).

Methods

Semi-structured interviews were conducted in two phases with 18 Chinese postgraduate OISs enrolled in a range of institutions and disciplines. Interviews took place online and were analyzed thematically to explore participants’ experiences.

Results

Stress was found to originate from both socially- and task-based factors, closely related to participants’ need to integrate into their on-campus community and gain useful knowledge and skills. Particular sources of stress were associated with distinct perceptions and subsequent responses and management strategies.

Discussion

A summarizing theoretical model is offered to highlight the separate construct of distress and eustress, indicating tentative causal relationships to extend existing stress models to an educational context and provide new insights into OISs. Practical implications are identified and recommendations are provided for policy-makers, teachers, and students.
Hopelessness and burnout in Italian healthcare workers during COVID-19 pandemic: the mediating role of trait emotional intelligence
Authors: Epifanio Maria Stella , La Grutta Sabina , Piombo Marco Andrea , Riolo Martina , Spicuzza Vittoria , Franco Marianna , Mancini Giacomo , De Pascalis Leonardo , Trombini Elena , Andrei Federica
Published: May 2023

Objective

The study aims to assess the impact of COVID-19 on healthcare workers’ work-related stress during the first wave of the pandemic in Italy. The main objective is to investigate the existence of a positive correlation between hopelessness and burnout, assuming that burnout may be a risk factor for the development of hopelessness, and to analyze the role that trait Emotional Intelligence (TEI) and changes in workload could have in this relationship. Furthermore, evaluate any significant differences in burnout and hopelessness levels in the function of some demographic variables, such as gender, professional profiles, and different working zones of Italy, to better understand how the diverse diffusion of pandemic had affected Italian healthcare workers.

Methods

An online survey was used to collect data between April and June, 2020, with 562 responses among nurses (52.1%) and physicians (47.9%). Demographics and changes in workload and work conditions were collected through an ad hoc questionnaire. The Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF), The Beck Hopelessness Scale (BHS), and the Link Burnout Questionnaire (LBQ) were used to assess Trait Emotional Intelligence (TEI), hopelessness, and burnout, respectively.

Results

Correlation analysis showed a significant positive relationship between hopelessness and each burnout dimension. TEI showed negative correlations both with burnout dimensions and hopelessness. Significant differences in burnout and hopelessness levels emerged as a function of some demographic variables such as gender, professional profiles (nurses or physicians), and different working zone of Italy (northern or southern). Results showed that TEI partially mediated the relationship between hopelessness and every burnout dimension, while the interaction of changes in workload was non-significant.

Discussion

The mediating role of TEI in the burnout-hopelessness relationship partly explains the protective role that individual factors had on healthcare workers’ mental health. Our findings support the need to integrate considerations on both psychological risk and protective factors into COVID-19 care, including the monitoring of psychological symptoms and social needs, especially among healthcare workers.
Gender differences and left-behind experiences in the relationship between gaming disorder, rumination and sleep quality among a sample of Chinese university students during the late stage of the COVID-19 pandemic
Authors: Li Li , Liu Ligang , Niu Zhimin , Zhong Huahua , Mei Songli , Griffiths Mark D.
Published: May 2023

Background and aims

Studies have shown that gaming disorder (GD) is associated with rumination and poor sleep quality. However, the reciprocal relationship between GD, rumination and sleep quality is unclear. Moreover, the differences between gender and between left-behind experiences in the aforementioned relationship remain unknown. Therefore, the present study examined gender differences and left-behind experiences in the relationship between GD, rumination, and sleep quality among a sample of Chinese university students during the late stage of COVID-19 pandemic using a network analysis approach.

Methods

A cross-sectional online survey of 1,872 Chinese university students was conducted comprising demographic information (age, gender, and left-behind experience), gaming experience, gaming frequency, Gaming Disorder Test (GDT), Short Version of Rumination Response Scale (RRS), and Pittsburgh Sleep Quality Index (PSQI).

Results

Among Chinese university students, the prevalence of (i) GD was 3.5% and (ii) sleep disturbance was 14%. GD had positive and weak connection with rumination and sleep quality in the domain-level relational network. The network structures and global strengths both showed no significant differences between gender and between left-behind experiences. The nodes gd3 (“continuation or escalation of gaming”) and gd4 (“gaming problems”) had the strongest edge in the network.

Conclusion

The results suggest reciprocal relationships between GD, rumination, and sleep quality. Gender and left-behind experiences did not influence the reciprocal relationship between GD, rumination, and sleep quality during the late stage of COVID-19 pandemic. Using network analysis, the findings provide novel insights that rumination and sleep quality may have interacted with GD among Chinese students during the late stage of COVID-19 pandemic. Reducing or eliminating negative rumination may decrease GD and improve sleep quality. Moreover, good sleep quality contributes to positive rumination which may decrease the risk of GD among Chinese university students.
Functional connectivity of the cerebellar vermis in bipolar disorder and associations with mood
Authors: Saleem Arshaq , Harmata Gail , Jain Shivangi , Voss Michelle W. , Fiedorowicz Jess G. , Williams Aislinn J. , Shaffer Joseph J. , Richards Jenny Gringer , Barsotti Ercole John , Sathyaputri Leela , Schmitz Samantha L. , Christensen Gary E. , Long Jeffrey D. , Xu Jia , Wemmie John A. , Magnotta Vincent A.
Published: May 2023

Purpose

Studies of the neural underpinnings of bipolar type I disorder have focused on the emotional control network. However, there is also growing evidence for cerebellar involvement, including abnormal structure, function, and metabolism. Here, we sought to assess functional connectivity of the cerebellar vermis with the cerebrum in bipolar disorder and to assess whether connectivity might depend on mood.

Methods

This cross-sectional study enrolled 128 participants with bipolar type I disorder and 83 control comparison participants who completed a 3 T magnetic resonance imaging (MRI) study, which included anatomical as well as resting state Blood Oxygenation Level Dependent (BOLD) imaging. Functional connectivity of the cerebellar vermis to all other brain regions was assessed. Based on quality control metrics of the fMRI data, 109 participants with bipolar disorder and 79 controls were included in the statistical analysis comparing connectivity of the vermis. In addition, the data was explored for the potential impacts of mood, symptom burden, and medication in those with bipolar disorder.

Results

Functional connectivity between the cerebellar vermis and the cerebrum was found to be aberrant in bipolar disorder. The connectivity of the vermis was found to be greater in bipolar disorder to regions involved in motor control and emotion (trending), while reduced connectivity was observed to a region associated with language production. In the participants with bipolar disorder, past depression symptom burden affected connectivity; however, no effects of medication were observed. Functional connectivity between the cerebellar vermis and all other regions revealed an inverse association with current mood ratings.

Conclusion

Together the findings may suggest that the cerebellum plays a compensatory role in bipolar disorder. The proximity of the cerebellar vermis to the skull may make this region a potential target for treatment with transcranial magnetic stimulation.
Implementing a stakeholder-driven community diffusion-informed intervention to create healthier, more equitable systems: a community case study in Greenville County, South Carolina
Authors: Calancie Larissa , Fair Melissa L. , Wills Sally , Werner Kelsey , Appel Julia M. , Moore Travis R. , Hennessy Erin , Economos Christina D.
Published: May 2023

This case study describes the application of a theory-informed, stakeholder-driven intervention with a group of 19 multi-sector stakeholders from an existing coalition to promote whole-of-community change that supports childhood obesity prevention. The intervention applied community-based system dynamics to design and implement activities that promoted insights into the systems driving childhood obesity prevalence and helped participants prioritize actions to influence those systems. This led to three new priority areas for the coalition: addressing food insecurity; building power among historically marginalized voices within the community; and supporting advocacy efforts to promote community-wide change beyond the coalition’s previous focus on organizational-level policy, systems and environment change. The intervention spurred the application of community-based system dynamics to other health issues and in partner organizations, which demonstrates paradigm shifts about how to address complex public health issues in the community.
Factors affecting wearable ECG device adoption by general practitioners for atrial fibrillation screening: cross-sectional study
Authors: Yao Yi , Li Zhichao , He Yi , Zhang Yalin , Guo Zhaoxia , Lei Yi , Zhao Qian , Li Dongze , Zhang Zhi , Zhang Yonggang , Liao Xiaoyang
Published: May 2023

Introduction

Atrial fibrillation (AF) is a challenging cardiovascular disease worldwide. Wearable electrocardiograph devices (WEDs) have great potential to improve the detection rate of AF in primary care. However, the factors that influence general practitioners’ (GPs) perception and acceptance of WEDs are not well understood. To identify factors that influence the intention of GPs to utilize WEDs in a clinical setting to screen patients for AF.

Method

The research hypotheses and questionnaire items were designed and developed based on the unified theory of acceptance and technology (UTAUT) framework. We used stratified sampling and obtained the data through an online survey. Structural equation modeling was used to analyze the collected data.Results: A total of 1,004 valid questionnaires from GPs across Sichuan province in China were collected. Three factors increased GPs’ intention to utilize WEDs to screen patients for AF, including performance expectancy (β = 0.121, p = 0.004), social influence (β = 0.356, p < 0.001), and price perception (β = 0.587, p < 0.001). Perception risk (β = −0.059, p < 0.001) decreased usage intention, while effort expectancy (β = −0.079, p = 0.155) and facilitating conditions (β = −0.014, p = 0.868) did not affect usage intention. Gender (β = −0.022, p = 0.179), age (β = 0.006, p = 0.699), education level (β = −0.22, p = 0.184) and training (β = 0.007, p = 0.69) were not significantly correlated with usage intention, and these four factors had no moderating effect on the path coefficients.

Discussion

GPs’ intention to utilize WEDs is affected by performance expectancy, price perception, perception risk and social influence. Researcher should improve the usability and perception of WEDs for screening and carry out studies to provide high-quality evidence for the security and efficacy of wearable devices.
The rapid change in mental health among college students after introduction of on-campus quarantine during the 2022 Shanghai COVID-19 lockdown
Authors: Ma Dongni , Kuang Yifang , Lan Zhaohui , Zeng Suhua , Li Yi , Shang Mengnan , Zhang Ru-Yuan , Zhao Binglei , Li Weidong
Published: May 2023

Objectives

Among the various impacts of disasters in terms of emotions, quarantine has been proven to result in significant increases in mental health problems. Studies of psychological resilience during outbreaks of epidemics tend to focus on long-term social quarantine. In contrast, insufficient studies have been conducted examining how rapidly negative mental health outcomes occur and how these outcomes change over time. We evaluated the time course of psychological resilience (over three different phases of quarantine) among students at Shanghai Jiao Tong University to investigate the influence of unexpected changes on college students.

Methods

An online survey was conducted from 5 to 7 April 2022. A structured online questionnaire was administered using a retrospective cohort trial design. Before 9 March (Period 1), individuals engaged in their usual activities without restrictions. From 9 to 23 March (Period 2), the majority of students were asked to remain in their dormitories on campus. From 24 March to early April (Period 3), restrictions were relaxed, and students were gradually allowed to participate in essential activities on campus. We quantified dynamic changes in the severity of students’ depressive symptoms over the course of these three periods. The survey consisted of five sets of self-reported questions: demographic information, lifestyle/activity restrictions, a brief mental health history, COVID-19-related background, and the Beck Depression Inventory, second edition.

Results

A total of 274 college students aged 18–42 years (mean = 22.34; SE = 0.24) participated in the study (58.39% undergraduate students, 41.61% graduate students; 40.51% male, 59.49% female). The proportion of students with depressive symptoms was 9.1% in Period 1, 36.1% in Period 2, and 34.67% in Period 3. Depressive symptoms increased notably with the introduction of the quarantine in Periods 2 and 3. Lower satisfaction with the food supplied and a longer duration of physical exercise per day were found to be positively associated with changes in depression severity in Periods 2 and 3. Quarantine-related psychological distress was more evident in students who were in a romantic relationship than in students who were single.

Conclusion

Depressive symptoms in university students rapidly increased after 2 weeks of quarantine and no perceptible reversal was observed over time. Concerning students in a relationship, ways to take physical exercise and to relax should be provided and the food supplied should be improved when young people are quarantined.
Gender differences in the modifying effect of living arrangements on the association of sleep quality with cognitive function among community-dwelling older adults: a cross-sectional study
Authors: Yang Haifeng , Xu Lingzhong , Qin Wenzhe , Hu Fangfang , Li Lei , Chen Chenhui , Tang Wenlong
Published: May 2023

Background

Sleep quality is considered to be associated with cognitive function for older adults, but little is known about whether living with others can buffer mild cognitive impairment in older adults with poor sleep quality. The objective of this study was to examine the role of living arrangements in sleep quality and cognitive function among older adults aged 65 and over.

Methods

2,859 older adults over 65 years old were selected by using multi-stage stratified sampling method. Cognitive function and sleep quality were measured using Mini-Mental State Examination (MMSE) and Pittsburgh Sleep Quality Index (PSQI). Binary logistic regression was performed to examine the relationship between sleep quality and mild cognitive impairment, and the interaction effects of sleep quality and living arrangements on mild cognitive impairment stratified by gender.

Results

Poor sleep quality was associated with mild cognitive impairment among men and women regardless of living arrangements. The significantly protective role of living with others in reducing the incidence of mild cognitive impairment was found in men with poor sleep quality, but not in women.

Conclusion

Targeted support for older adults with poor sleep quality may be effective in preventing mild cognitive impairment, and gender differences should be taken into account when promoting cohabitations.
Development of effective human factors interventions for aviation safety management
Authors: Chan Wesley Tsz-Kin , Li Wen-Chin
Published: May 2023

Introduction

In the aviation industry, safety management has moved away from capturing frontline failures toward the management of systemic conditions through organizational safety management systems (SMS). However, subjective differences can influence the classification of active failures and their associated systemic precursors. With levels of professional experience known to influence safety attitudes, the present research examines whether experience levels among airline pilots had an impact on the classification of causal factors using the Human Factors Analysis and Classification System (HFACS). Differences in the paths of association between categories were evaluated in an open-system context.

Method

Pilots working in a large, international airline were categorized into high (≥10,000 total flight hours) and low (<10,000 h) experience groups and asked to classify aircraft accident causal factors using the HFACS framework. One-way ANOVA tests were carried out to determine experience effects on the utilization of the HFACS categories, and chi-squared analyses were used to assess the strength of association between different categories within the framework.

Results

Results from 144 valid responses revealed differences in the attribution of human factors conditions. The high experience group was more inclined to attribute deficiencies to high-level precursors and found fewer paths of associations between different categories. In contrast, the low experience group presented a greater number of associations and was comparatively more affected by stress and uncertainty conditions.

Discussion

The results confirm that the classification of safety factors can be influenced by professional experience, with hierarchical power distance impacting the attribution of failures to higher-level organizational faults. Different paths of association between the two groups also suggest that safety interventions can be targeted through different entry points. Where multiple latent conditions are associated, the selection of safety interventions should be made with consideration of the concerns, influences, and actions across the entire system. Higher-level anthropological interventions can change the interactive interfaces affecting concerns, influences, and actions across all levels, whereas frontline-level functional interventions are more efficient for failures linked to many precursor categories.
Parent–child relationships and psychological distress: survey of parents from low-income families after the COVID-19 pandemic
Authors: Wong Li Ping , Alias Haridah , Farid Nik Daliana Nik , Yusop Sofia Md , Musa Zuhrah , Hu Zhijian , Lin Yulan
Published: May 2023

Introduction

This study aims to shed light on parent–child relationships and the psychological health of parents from low-income families after the easing of the COVID-19 pandemic restrictions.

Methods

This cross-sectional study recruited 553 parents of children aged 13–24 years in low-income community settings. The Parent–Child Conflict scale of the Parental Environment Questionnaire (PEQ) was used to measure parent–child conflict. Psychological distress was assessed using the Depression, Anxiety, and Stress Scale short form (DASS-21).

Results

The study revealed a low level of parent–child conflict in the overall study population, with a median PEQ of 48.0 (interquartile range [IQR] 36 to 48). Concerning demographics, married parents reported a likelihood of having a higher level of parent–child conflict over 3 times higher than single parents (OR = 3.18 95%, CI 1.30–7.75). More parent–child conflicts were also found in parents aged 60–72 years old who were unemployed, retired, or housewives and from lower-income groups. In regard to lifestyle factors, a higher level of physical activity and having enough sleep were associated with lower levels of parent–child conflict. Only approximately 1% of the participants reported symptoms of depression, anxiety, or stress.

Discussion

Low risk exists for parent–child conflict and psychological sequelae following the easing of the COVID-19 pandemic restrictions, which could be due to various support measures implemented by the government. Vulnerable parents identified as being at risk of parent–child conflict warrant attention in future advocacy efforts.
Changing spatiotemporal patterns for hepatitis of unspecified aetiology in China, 2004–2021: a population-based surveillance study
Authors: Zhao Na , Guo Xiangyu , Wang Lan , Zhou Hongming , Gong Lei , Miao Ziping , Chen Yijuan , Qin Shuwen , Yu Zhao , Liu Shelan , Wang Supen
Published: May 2023

Objectives

As global efforts continue toward the target of eliminating viral hepatitis by 2030, the emergence of acute hepatitis of unspecified aetiology (HUA) remains a concern. This study assesses the overall trends and changes in spatiotemporal patterns in HUA in China from 2004 to 2021.

Methods

We extracted the incidence and mortality rates of HUA from the Public Health Data Center, the official website of the National Health Commission of the People’s Republic of China, and the National Notifiable Infectious Disease Surveillance System from 2004 to 2021. We used R software, ArcGIS, Moran’s statistical analysis, and joinpoint regression to examine the spatiotemporal patterns and annual percentage change in incidence and mortality of the HUA across China.

Results

From 2004 to 2021, a total of 707,559 cases of HUA have been diagnosed, including 636 deaths. The proportion of HUA in viral hepatitis gradually decreased from 7.55% in 2004 to 0.72% in 2021. The annual incidence of HUA decreased sharply from 6.6957 per 100,000 population in 2004 to 0.6302 per 100,000 population in 2021, with an average annual percentage change (APC) reduction of −13.1% (p < 0.001). The same result was seen in the mortality (APC, −22.14%, from 0.0089/100,000 in 2004 to 0.0002/100,000 in 2021, p < 0.001). All Chinese provinces saw a decline in incidence and mortality. Longitudinal analysis identified the age distribution in the incidence and mortality of HUA did not change and was highest in persons aged 15–59 years, accounting for 70% of all reported cases. During the COVID-19 pandemic, no significant increase was seen in pediatric HUA cases in China.

Conclusion

China is experiencing an unprecedented decline in HUA, with the lowest incidence and mortality for 18 years. However, it is still important to sensitively monitor the overall trends of HUA and further improve HUA public health policy and practice in China.
Highlighting the value of Alzheimer’s disease-focused registries: lessons learned from cancer surveillance
Authors: Miller Margaret C. , Bayakly Rana , Schreurs Bernard G. , Flicker Kimberly J. , Adams Swann Arp , Ingram Lucy A. , Hardin James W. , Lohman Matthew , Ford Marvella E. , McCollum Quentin , McCrary-Quarles Audrey , Ariyo Oluwole , Levkoff Sue E. , Friedman Daniela B.
Published: May 2023

Like cancer, Alzheimer’s disease and related dementias (ADRD) comprise a global health burden that can benefit tremendously from the power of disease registry data. With an aging population, the incidence, treatment, and mortality from ADRD is increasing and changing rapidly. In the same way that current cancer registries work toward prevention and control, so do ADRD registries. ADRD registries maintain a comprehensive and accurate registry of ADRD within their state, provide disease prevalence estimates to enable better planning for social and medical services, identify differences in disease prevalence among demographic groups, help those who care for individuals with ADRD, and foster research into risk factors for ADRD. ADRD registries offer a unique opportunity to conduct high-impact, scientifically rigorous research efficiently. As research on and development of ADRD treatments continue to be a priority, such registries can be powerful tools for conducting observational studies of the disease. This perspectives piece examines how established cancer registries can inform ADRD registries’ impact on public health surveillance, research, and intervention, and inform and engage policymakers.
Preparation of human amniotic membrane for transplantation in different application areas
Authors: Hofmann Nicola , Rennekampff Hans-Oliver , Salz Anna Katharina , Börgel Martin
Published: May 2023

The human amniotic membrane (hAM) is the inner layer of the placenta and plays protective and nutritional roles for the fetus during pregnancy. It contains multiple growth factors and proteins that mediate unique regenerative properties and enhance wound healing in tissue regeneration. Due to these characteristics hAM has been successfully utilized in ophthalmology for many decades. This material has also found application in a variety of additional therapeutic areas. Particularly noteworthy are the extraordinary effects in the healing of chronic wounds and in the treatment of burns. But hAM has also been used successfully in gynecology, oral medicine, and plastic surgery and as a scaffold for in vitro cell culture approaches. This review aims to summarize the different graft preparation, preservation and storage techniques that are used and to present advantages and disadvantages of these methods. It shows the characteristics of the hAM according to the processing and storage methods used. The paper provides an overview of the currently mainly used application areas and raises new application possibilities. In addition, further preparation types like extracts, homogenates, and the resulting treatment alternatives are described.
A critical mini-review on the low-field nuclear magnetic resonance investigation of pore coupling effects in near-surface environments
Authors: Soto Bravo Francisca , Zhang Chi
Published: May 2023

The assessment and monitoring of groundwater resources is of increasing importance to ensure the continuous supply of fresh water for human activity and endangered ecosystems. These groundwater resources include fully saturated aquifers, water in unsaturated soil, and water trapped as rock moisture in weathered bedrocks. Low-field nuclear magnetic resonance (NMR) is a method with unique sensitivity to pore water, as it is based on the magnetization and relaxation behavior of the spin magnetic moment of hydrogen atoms forming water molecules. It is a cost-effective and minimally-invasive technology that can help characterize the pore structures and the groundwater distribution and transport in different types of subsurface materials. However, the interpretation of NMR data from samples with complex bimodal or multimodal porous geometries requires the consideration of pore coupling effects. A pore-coupled system presents significant magnetization exchange between macro- and micropores within the measurement time, making the independent characterization of each pore environment difficult. Developing a better understanding of pore coupling is of great importance for the accurate estimation of hydrogeological parameters from NMR data. This mini-review presents the state-of-art in research exploring the two factors controlling pore coupling: surface geochemistry and network connectivity, summarizes existing experimental and numerical modeling approaches that have been used to study pore coupling and discusses the pore coupling effects in fully and partially saturated conditions. At the end of this review, we outline major knowledge gaps and highlight the research needs in the vadose zone.
Training load comparison between small, medium, and large-sided games in professional football
Authors: Beato Marco , Vicens-Bordas Jordi , Peña Javier , Costin Andrew J.
Published: May 2023

This study aimed to assess if internal and external load parameters were different between sided game formats, if players' positions influenced these parameters, and if load parameters were different among sided game types (from 2vs2 to 10vs10) in professional football players. Twenty-five male players of the same club were enrolled in this study (age = 27 ± 9 years and body mass = 78 ± 14 kg). Sided games were categorized in formats as small-sided games (SSG, n = 145), medium-sided games (MSG, n = 431), and large-sided games (LSG, n = 204). Players were divided into roles such as center backs (CB), fullbacks (FB), center midfielders (CM), attacking midfielders (AM), and strikers (ST). STATSports 10 Hz GNSS Apex units were used to monitor external load parameters such as distance, high-speed running (HSR), sprinting distance, accelerations, and decelerations. The linear mixed model analysis found differences between formats (p < 0.001) for the rate of perceived exertion (RPE), distance, HSR, sprinting, accelerations, and decelerations. Differences were found between positions for HSR (p = 0.004), sprinting (p = 0.006), and decelerations (p < 0.001). Moreover, a significant difference was found between sided game types (p < 0.001) for RPE, distance, HSR, sprinting, accelerations, and decelerations. In conclusion, some sided games formats are more suitable for specific load-specific parameters (e.g., distance per minute, HSR, and sprinting are greater during LSG). The number of accelerations and decelerations is higher in MSG compared to other formats. Finally, players' positions influenced external load metrics, specifically HSR and decelerations but not RPE and distance.