bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 5 from ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation
Authors: Biddlestone-Thorpe Laura , Sajjad Muhammad , Rosenberg Elizabeth , Beckta Jason M. , Valerie Nicholas C.K. , Tokarz Mary , Adams Bret R. , Wagner Alison F. , Khalil Ashraf , Gilfor Donna , Golding Sarah E. , Deb Sumitra , Temesi David G. , Lau Alan , O'Connor Mark J. , Choe Kevin S. , Parada Luis F. , Lim Sang Kyun , Mukhopadhyay Nitai D. , Valerie Kristoffer
Published: April 2023

PDF File - 578K, Human U1242/luc-GFP gliomas show dose-dependent increases in p-(S824)-KAP1 foci formation after radiation which can be inhibited by KU-60019.
Supplementary Figure 3 from ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation
Authors: Biddlestone-Thorpe Laura , Sajjad Muhammad , Rosenberg Elizabeth , Beckta Jason M. , Valerie Nicholas C.K. , Tokarz Mary , Adams Bret R. , Wagner Alison F. , Khalil Ashraf , Gilfor Donna , Golding Sarah E. , Deb Sumitra , Temesi David G. , Lau Alan , O'Connor Mark J. , Choe Kevin S. , Parada Luis F. , Lim Sang Kyun , Mukhopadhyay Nitai D. , Valerie Kristoffer
Published: April 2023

PDF File - 49K, Imaging of tumors that were apparently cured.
Supplementary Methods from PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer
Authors: Khan Mohammad W. , Keshavarzian Ali , Gounaris Elias , Melson Joshua E. , Cheon Eric C. , Blatner Nichole R. , Chen Zongmin E. , Tsai Fu-Nien , Lee Goo , Ryu Hyunji , Barrett Terrence A. , Bentrem David J. , Beckhove Philipp , Khazaie Khashayarsha
Published: April 2023

PDF file - 54K, Toluidine Blue staining protocol.
Supplementary Figure 8 from PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer
Authors: Khan Mohammad W. , Keshavarzian Ali , Gounaris Elias , Melson Joshua E. , Cheon Eric C. , Blatner Nichole R. , Chen Zongmin E. , Tsai Fu-Nien , Lee Goo , Ryu Hyunji , Barrett Terrence A. , Bentrem David J. , Beckhove Philipp , Khazaie Khashayarsha
Published: April 2023

PDF file - 55K, Mast cells promote in vitro and in vivo Gr1+ neutrophil and Foxp3+ Tregs migration in PI3K dependent manner. (A) GMMCs promote Gr1+ neutrophil in vitro migration and pretreatment of GMMCs with LY294002 attenuates migration of Gr1+ cells (B) LY294002 in vivo treatment attenuates migration of Gr1+ neutrophils (C) LY294002 in vivo treatment attenuates migration of Foxp3+ Tregs, * P < 0.05 represents the result of ANOVA.
Supplementary Figure 7 from PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer
Authors: Khan Mohammad W. , Keshavarzian Ali , Gounaris Elias , Melson Joshua E. , Cheon Eric C. , Blatner Nichole R. , Chen Zongmin E. , Tsai Fu-Nien , Lee Goo , Ryu Hyunji , Barrett Terrence A. , Bentrem David J. , Beckhove Philipp , Khazaie Khashayarsha
Published: April 2023

PDF file - 139K, Multiplex ELISA data for C57BL/6J mouse mast cell supernatant (unstimulated).
Supplementary Figure 6 from PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer
Authors: Khan Mohammad W. , Keshavarzian Ali , Gounaris Elias , Melson Joshua E. , Cheon Eric C. , Blatner Nichole R. , Chen Zongmin E. , Tsai Fu-Nien , Lee Goo , Ryu Hyunji , Barrett Terrence A. , Bentrem David J. , Beckhove Philipp , Khazaie Khashayarsha
Published: April 2023

PDF file - 40K, Multiplex ELISA data for human inflammatory chemoattractants.
Supplementary Table 4 from Genetic Profiling Identifies Two Classes of Soft-Tissue Leiomyosarcomas with Distinct Clinical Characteristics
Authors: Italiano Antoine , Lagarde Pauline , Brulard Céline , Terrier Philippe , Laë Marick , Marques Bernard , Ranchere-Vince Dominique , Michels Jean-Jacques , Trassard Martine , Cioffi Angela , Piperno-Neumann Sophie , Chevreau Christine , Blay Jean-Yves , Delcambre Corinne , Isambert Nicolas , Penel Nicolas , Bay Jacques-Olivier , Bonvalot Sylvie , Le Cesne Axel , Coindre Jean-Michel , Chibon Frédéric
Published: April 2023

PDF file - 60K, Biological pathways overrepresented in "REARRANGED" LMS and LMS of the extremities
Supplementary Figure 3 from PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer
Authors: Khan Mohammad W. , Keshavarzian Ali , Gounaris Elias , Melson Joshua E. , Cheon Eric C. , Blatner Nichole R. , Chen Zongmin E. , Tsai Fu-Nien , Lee Goo , Ryu Hyunji , Barrett Terrence A. , Bentrem David J. , Beckhove Philipp , Khazaie Khashayarsha
Published: April 2023

PDF file - 173K, Tumor/Margin frequency of CD4 T cells is inversely related to Macrophages and Mast cells. (A) Graphical Representation and (B) Representative images of the CD11b, Mac387, Tryptase, CAE and CD4 cells in tumor and tumor margin area.
Supplementary Table 3 from Genetic Profiling Identifies Two Classes of Soft-Tissue Leiomyosarcomas with Distinct Clinical Characteristics
Authors: Italiano Antoine , Lagarde Pauline , Brulard Céline , Terrier Philippe , Laë Marick , Marques Bernard , Ranchere-Vince Dominique , Michels Jean-Jacques , Trassard Martine , Cioffi Angela , Piperno-Neumann Sophie , Chevreau Christine , Blay Jean-Yves , Delcambre Corinne , Isambert Nicolas , Penel Nicolas , Bay Jacques-Olivier , Bonvalot Sylvie , Le Cesne Axel , Coindre Jean-Michel , Chibon Frédéric
Published: April 2023

PDF file - 60K, Biological pathways overrepresented in "ARM" and internal trunk LMS
Supplementary Figure 2 from PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer
Authors: Khan Mohammad W. , Keshavarzian Ali , Gounaris Elias , Melson Joshua E. , Cheon Eric C. , Blatner Nichole R. , Chen Zongmin E. , Tsai Fu-Nien , Lee Goo , Ryu Hyunji , Barrett Terrence A. , Bentrem David J. , Beckhove Philipp , Khazaie Khashayarsha
Published: April 2023

PDF file - 125K, (A) Representative images of HT-29 invasion study in response to Stempro + SCF (internal control for LAD-2 CM), LAD-2 CM, CM + 10 �M LY294002 (LAD-2 CM with 10 �M LY294002) and 10 �M LY pretreated CM (CM obtained after treatment of LAD-2 cells with 10 �M LY294002). (B) Representative images of CFSE labeled HT-29 invasion study in response to tumor infiltrating leukocytes (TILs) isolated from UC associated cancer patients. Red arrows show invaded HT-29. Red scale bar = 50 �m, * P < 0.05 represents the result of Student t test.
Supplementary Figure 1 from PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer
Authors: Khan Mohammad W. , Keshavarzian Ali , Gounaris Elias , Melson Joshua E. , Cheon Eric C. , Blatner Nichole R. , Chen Zongmin E. , Tsai Fu-Nien , Lee Goo , Ryu Hyunji , Barrett Terrence A. , Bentrem David J. , Beckhove Philipp , Khazaie Khashayarsha
Published: April 2023

PDF file - 153K, LY294002 attenuates mast cell mediated CD11b+ cell migration. Representative images of migration of CD11b cells in response to (A) Stempro +SCF (control), (B) LAD-2 CM (LAD-2 conditioned medium), (C) LAD-2 CM + 10 �M LY294002 (LAD-2 CM with 10 �M LY294002) and (D) CM obtained after pretreatment of LAD-2 cells with 10 �M LY294002. (E) Purity of CD11b+ cells obtained after using either biotinylated Rat ant-human CD11b or biotinylated Rat IgG2bK. Black arrows indicate migrated CD11b+ cells. Black scale bar = 20 �m.
Supplementary Table 1 from Genetic Profiling Identifies Two Classes of Soft-Tissue Leiomyosarcomas with Distinct Clinical Characteristics
Authors: Italiano Antoine , Lagarde Pauline , Brulard Céline , Terrier Philippe , Laë Marick , Marques Bernard , Ranchere-Vince Dominique , Michels Jean-Jacques , Trassard Martine , Cioffi Angela , Piperno-Neumann Sophie , Chevreau Christine , Blay Jean-Yves , Delcambre Corinne , Isambert Nicolas , Penel Nicolas , Bay Jacques-Olivier , Bonvalot Sylvie , Le Cesne Axel , Coindre Jean-Michel , Chibon Frédéric
Published: April 2023

PDF file - 61K, Clinical characteristics of the molecular cohort (N=73)
Supplementary Figure 4 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH-Mutant Gliomas
Authors: Wakimoto Hiroaki , Tanaka Shota , Curry William T. , Loebel Franziska , Zhao Dan , Tateishi Kensuke , Chen Juxiang , Klofas Lindsay K. , Lelic Nina , Kim James C. , Dias-Santagata Dora , Ellisen Leif W. , Borger Darrell R. , Fendt Sarah-Maria , Vander Heiden Matthew G. , Batchelor Tracy T. , Iafrate A. John , Cahill Daniel P. , Chi Andrew S.
Published: April 2023

PDF file - 323KB, Supplementary Figure S4. Sequencing of the IDH1 R132 locus in IDH1-mutant glioma xenografts.
Supplementary Figure 3 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH-Mutant Gliomas
Authors: Wakimoto Hiroaki , Tanaka Shota , Curry William T. , Loebel Franziska , Zhao Dan , Tateishi Kensuke , Chen Juxiang , Klofas Lindsay K. , Lelic Nina , Kim James C. , Dias-Santagata Dora , Ellisen Leif W. , Borger Darrell R. , Fendt Sarah-Maria , Vander Heiden Matthew G. , Batchelor Tracy T. , Iafrate A. John , Cahill Daniel P. , Chi Andrew S.
Published: April 2023

PDF file - 347KB, Supplementary Figure S3. Proliferation index of IDH1-mutant glioma orthotopic xenografts (MIB-1).
Supplementary Figure 2 from Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH-Mutant Gliomas
Authors: Wakimoto Hiroaki , Tanaka Shota , Curry William T. , Loebel Franziska , Zhao Dan , Tateishi Kensuke , Chen Juxiang , Klofas Lindsay K. , Lelic Nina , Kim James C. , Dias-Santagata Dora , Ellisen Leif W. , Borger Darrell R. , Fendt Sarah-Maria , Vander Heiden Matthew G. , Batchelor Tracy T. , Iafrate A. John , Cahill Daniel P. , Chi Andrew S.
Published: April 2023

PDF file - 404KB, Supplementary Figure S2. IDH1-mutant glioma orthotopic xenografts recapitulate histopathological features of the respective patient tumors.
Supplementary Tables 1 - 4, Figure 1 from Decitabine Induces Delayed Reactive Oxygen Species (ROS) Accumulation in Leukemia Cells and Induces the Expression of ROS Generating Enzymes
Authors: Fandy Tamer E. , Jiemjit Anchalee , Thakar Manjusha , Rhoden Paulette , Suarez Lauren , Gore Steven D.
Published: April 2023

PDF file - 111K, Supplementary table S1. Primers sequence used in RealTime PCR. Supplementary table S2. DAC induces G2/M arrest in leukemia cells. Supplementary table S3. Impact of DAC on the expression of ROS generating and detoxifying enzymes. Supplementary table S4. Impact of 5AC on the expression of ROS generating and detoxifying enzymes. Supplementary figure 1. CEM cells and its isogenic dck negative cells were treated with DAC 500 nM for 72 h followed by apoptosis analysis.
Supplementary Figure Legends from Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy
Authors: Chandramohan Vidyalakshmi , Bao Xuhui , Keir Stephen T. , Pegram Charles N. , Szafranski Scott E. , Piao Hailan , Wikstrand Carol J. , McLendon Roger E. , Kuan Chien-Tsun , Pastan Ira H. , Bigner Darell D.
Published: April 2023

Supplementary Figure Legends - PDF file 88K, Supplementary Figure Legends 1-9
Supplementary Table 1 from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Authors: Touil Yasmine , Igoudjil Wassila , Corvaisier Matthieu , Dessein Anne-Frédérique , Vandomme Jérôme , Monté Didier , Stechly Laurence , Skrypek Nicolas , Langlois Carole , Grard Georges , Millet Guillaume , Leteurtre Emmanuelle , Dumont Patrick , Truant Stéphanie , Pruvot François-René , Hebbar Mohamed , Fan Fan , Ellis Lee M. , Formstecher Pierre , Van Seuningen Isabelle , Gespach Christian , Polakowska Renata , Huet Guillemette
Published: April 2023

PDF file - 55K, Table S1. Expression of cell surface stem cell markers in parental HT29 cells, its 5FUresistant 5F7 and 5F31 clonal derivatives, 5FU- and oxaliplatin-resistant HT29FU and HT29OXA subpopulations.
Supplementary Tables 1-7 from DNA Methylation as an Adjunct to Histopathology to Detect Prevalent, Inconspicuous Dysplasia and Early-Stage Neoplasia in Barrett's Esophagus
Authors: Alvi Muhammad A. , Liu Xinxue , O'Donovan Maria , Newton Richard , Wernisch Lorenz , Shannon Nicholas B. , Shariff Kareem , di Pietro Massimiliano , Bergman Jacques J.G.H.M. , Ragunath Krish , Fitzgerald Rebecca C.
Published: April 2023

PDF file - 89K,Supplementary Table 1: Patient demographics for the methylation arrays. (BE=Barrett's esophagus, EAC=esophageal adenocarcinoma). Supplementary Table 2: Patient demographics for retrospective external validation. (BE=Barrett's esophagus, BED=Barrett's esophagus with dysplasia, EAC=esophageal adenocarcinoma). Supplementary Table 3: Patient demographics for prospective validation. (BE=Barrett's esophagus, BED=Barrett's esophagus with dysplasia, EAC=esophageal adenocarcinoma). Supplementary Table 4: List of the top 30 hypermethylated genes in esophageal adenocarcinoma vs. Barrett's esophagus (Genes selected for validation are marked by an asterisk). Supplementary Table 5: Primer sequences and genomic co-ordinates for pyrosequencing assays. Supplementary Table 6: Primer sequences for pyrosequencing controls. Supplementary Table 7: Methylation cut-offs selected for maximum sensitivity and specificity in detecting dysplasia/adenocarcinoma
Supplementary Methods from Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Authors: Touil Yasmine , Igoudjil Wassila , Corvaisier Matthieu , Dessein Anne-Frédérique , Vandomme Jérôme , Monté Didier , Stechly Laurence , Skrypek Nicolas , Langlois Carole , Grard Georges , Millet Guillaume , Leteurtre Emmanuelle , Dumont Patrick , Truant Stéphanie , Pruvot François-René , Hebbar Mohamed , Fan Fan , Ellis Lee M. , Formstecher Pierre , Van Seuningen Isabelle , Gespach Christian , Polakowska Renata , Huet Guillemette
Published: April 2023

PDF file - 107K
Supplementary Figure Legends from DNA Methylation as an Adjunct to Histopathology to Detect Prevalent, Inconspicuous Dysplasia and Early-Stage Neoplasia in Barrett's Esophagus
Authors: Alvi Muhammad A. , Liu Xinxue , O'Donovan Maria , Newton Richard , Wernisch Lorenz , Shannon Nicholas B. , Shariff Kareem , di Pietro Massimiliano , Bergman Jacques J.G.H.M. , Ragunath Krish , Fitzgerald Rebecca C.
Published: April 2023

PDF file - 34K,Legends for supplementary figure 1 and 2
Supplementary Figure 2 from DNA Methylation as an Adjunct to Histopathology to Detect Prevalent, Inconspicuous Dysplasia and Early-Stage Neoplasia in Barrett's Esophagus
Authors: Alvi Muhammad A. , Liu Xinxue , O'Donovan Maria , Newton Richard , Wernisch Lorenz , Shannon Nicholas B. , Shariff Kareem , di Pietro Massimiliano , Bergman Jacques J.G.H.M. , Ragunath Krish , Fitzgerald Rebecca C.
Published: April 2023

PDF file - 21K,RGN methylation levels in female patient samples
Supplementary Appendix 1 from Repeatability of Quantitative FDG-PET/CT and Contrast-Enhanced CT in Recurrent Ovarian Carcinoma: Test–Retest Measurements for Tumor FDG Uptake, Diameter, and Volume
Authors: Rockall Andrea G. , Avril Norbert , Lam Raymond , Iannone Robert , Mozley P. David , Parkinson Christine , Bergstrom Donald , Sala Evis , Sarker Shah-Jalal , McNeish Iain A. , Brenton James D.
Published: April 2023

PDF file - 36KB, Patient inclusion and exclusion criteria.
Supplementary Methods, Figure Legends, Tables 1 - 2 from Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET
Authors: Xiang Qingfeng , Chen Weiqiang , Ren Meng , Wang Jingnan , Zhang Hongwu , Deng David Y.B. , Zhang Lei , Shang Changzhen , Chen Yajin
Published: April 2023

PDF file - 145K, Supplementary Tables S1. Characteristics of 29 HCC patients. Supplementary Table 2. Effects of cabozantinib on body weight, tumor burden, microvessel density, cell proliferation, and apoptosis of MHCC97 and HepG2 xenografts.
Supplementary Figure 5 from Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET
Authors: Xiang Qingfeng , Chen Weiqiang , Ren Meng , Wang Jingnan , Zhang Hongwu , Deng David Y.B. , Zhang Lei , Shang Changzhen , Chen Yajin
Published: April 2023

PDF file - 79K, Cabozantinib inhibits phosphorylation of MET in lung tissue and liver metastases.
Supplemental Figure 4 from Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival
Authors: Li Qian , Wijesekera Olindi , Salas Sussan J. , Wang Joanna Y. , Zhu Mingxin , Aprhys Colette , Chaichana Kaisorn L. , Chesler David A. , Zhang Hao , Smith Christopher L. , Guerrero-Cazares Hugo , Levchenko Andre , Quinones-Hinojosa Alfredo
Published: April 2023

Supplementary SFig. 4. hAMSCs retain proliferation capacity when exposed to BTIC-CM in vitro.
Supplemental Figure 3 from Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival
Authors: Li Qian , Wijesekera Olindi , Salas Sussan J. , Wang Joanna Y. , Zhu Mingxin , Aprhys Colette , Chaichana Kaisorn L. , Chesler David A. , Zhang Hao , Smith Christopher L. , Guerrero-Cazares Hugo , Levchenko Andre , Quinones-Hinojosa Alfredo
Published: April 2023

Supplementary SFig. 3. hAMSCs-BMP4 promote differentiation of BTICs in vitro.
Supplementary Figure 3 from Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET
Authors: Xiang Qingfeng , Chen Weiqiang , Ren Meng , Wang Jingnan , Zhang Hongwu , Deng David Y.B. , Zhang Lei , Shang Changzhen , Chen Yajin
Published: April 2023

PDF file - 32K, Analysis of cyclin D1 expression and Apoptosis in HCC cells.
Supplementary Figure 2 from Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET
Authors: Xiang Qingfeng , Chen Weiqiang , Ren Meng , Wang Jingnan , Zhang Hongwu , Deng David Y.B. , Zhang Lei , Shang Changzhen , Chen Yajin
Published: April 2023

PDF file - 100K, Cabozantinib suppress colony-formation in HCC cells.
Supplemental Figure 1 from Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival
Authors: Li Qian , Wijesekera Olindi , Salas Sussan J. , Wang Joanna Y. , Zhu Mingxin , Aprhys Colette , Chaichana Kaisorn L. , Chesler David A. , Zhang Hao , Smith Christopher L. , Guerrero-Cazares Hugo , Levchenko Andre , Quinones-Hinojosa Alfredo
Published: April 2023

Supplementary SFig. 1. hAMSCs-BMP4 decrease migration of BTICs in vitro.
Supplementary Table S1 from Alpha-Smooth Muscle Actin (ACTA2) Is Required for Metastatic Potential of Human Lung Adenocarcinoma
Authors: Lee Hye Won , Park Young Mi , Lee Se Jeong , Cho Hyun Jung , Kim Duk-Hwan , Lee Jung-Il , Kang Myung-Soo , Seol Ho Jun , Shim Young Mog , Nam Do-Hyun , Kim Hyeon Ho , Joo Kyeung Min
Published: April 2023

PDF file - 61K, Primers for RT-qPCR.
Supplementary Figure 2 from microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2
Authors: Liao Wen-Ting , Li Ting-Ting , Wang Zheng-Gen , Wang Shu-Yang , He Mei-Rong , Ye Ya-Ping , Qi Lu , Cui Yan-Mei , Wu Ping , Jiao Hong-Li , Zhang Chi , Xie Yi-Jun , Wang Jun-Xian , Ding Yan-Qing
Published: April 2023

Supplementary Figure 2 - PDF file 68K, Supplementary Fig.S2. Inhibition of miR-224 changes the expression of cell cycle regulators
Supplementary Figure S3 from Alpha-Smooth Muscle Actin (ACTA2) Is Required for Metastatic Potential of Human Lung Adenocarcinoma
Authors: Lee Hye Won , Park Young Mi , Lee Se Jeong , Cho Hyun Jung , Kim Duk-Hwan , Lee Jung-Il , Kang Myung-Soo , Seol Ho Jun , Shim Young Mog , Nam Do-Hyun , Kim Hyeon Ho , Joo Kyeung Min
Published: April 2023

Supplementary Figure S3 - PDF file 86K, Supplementary Figure S3. ACTA2 silencing inhibited migratory activity in various lung cancer cells To investigate the effect of ACTA2 silencing on migration, various lung cancer cells (H1299, H322, H460, and A549) were transfected with ACTA2-specific siRNA (Santa Cruz); 24 hours (h) post-transfection, cells were resuspended into 12-well plate. Confluent cell surface was scratched manually with pipette tips and migration distance was calculated by measuring wound closure. Data are shown as mean plus standard deviation from 3 separate experiments. *, P<0.05
Supplementary Table 1 from BRaf and MEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma
Authors: Breunig Christian , Mueller Bernadett J. , Umansky Ludmila , Wahl Kristin , Hoffmann Katrin , Lehner Frank , Manns Michael P. , Bantel Heike , Falk Christine S.
Published: April 2023

Two way ANOVA statistics of phosphorylated MEK1 and ERK1/2 after MAPKi treatment. Values of phosphoplex data of mean fluorescence intensities (MFI) from 30-60 beads for each kinase at each time point were calculated against the respective DMSO value using the 2 way ANOVA statistic. Indicated p-values are defined as *p{less than or equal to}0.05, **p{less than or equal to}0.01, ***p{less than or equal to}0.001, ns= not significant.
Supplementary Table 1 from Inhibition of Protein Kinase C/Twist1 Signaling Augments Anticancer Effects of Androgen Deprivation and Enzalutamide in Prostate Cancer
Authors: Shiota Masaki , Yokomizo Akira , Takeuchi Ario , Imada Kenjiro , Kashiwagi Eiji , Song YooHyun , Inokuchi Junichi , Tatsugami Katsunori , Uchiumi Takeshi , Naito Seiji
Published: April 2023

XLSX file 9K, Taget sequense of siRNAs
Supplementary Figure 3B from BRaf and MEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma
Authors: Breunig Christian , Mueller Bernadett J. , Umansky Ludmila , Wahl Kristin , Hoffmann Katrin , Lehner Frank , Manns Michael P. , Bantel Heike , Falk Christine S.
Published: April 2023

Alteration of total protein amount of MEK1, ERK1/2, c-Jun, Akt and ATF2 by MAPK inhibition. Total amount of MEK1, ERK1/2, c-Jun, Akt and ATF2 of HepG2 (A), Hep3B (B) and Huh-7 (C) cells after treatment with 0.2, 1 or 5µM sorafenib, PLX4720, U0126, AZD6244, PD0325901, GW5074 or sunitinib at different time points.
Supplementary Table 1 from A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells
Authors: Hight Matthew R. , Cheung Yiu-Yin , Nickels Michael L. , Dawson Eric S. , Zhao Ping , Saleh Samir , Buck Jason R. , Tang Dewei , Washington M. Kay , Coffey Robert J. , Manning H. Charles
Published: April 2023

PDF file - 43KB, Docking scores are reported as ranked by the Crash (steric repulsion) score from the protein flexibility (PF-score) scoring function of the Tripos SYBYL-X v2.0 software suite that also features (among other scoring parameters) comparison with SurflexDock Total_Score (statistical estimate of binding affinity, -log Kd), Polar (measure of polar contacts), Strain (measure of internal ligand energetic strain) and Similarity (index of shape-based morphological similarity to reference covalent inhibitor compound) term score parameters. Proposed N-terminal modifications to the VAD-FMK peptide scaffold all scored comparably using these criteria indicating minimal predicted perturbation to interactions with the caspase-3 protein target.
Supplementary Figure 2 from A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells
Authors: Hight Matthew R. , Cheung Yiu-Yin , Nickels Michael L. , Dawson Eric S. , Zhao Ping , Saleh Samir , Buck Jason R. , Tang Dewei , Washington M. Kay , Coffey Robert J. , Manning H. Charles
Published: April 2023

PDF file - 90KB, Scheme 1. 19FFB-VAD-FMK (3) (A) and 127IIZ-VAD-FMK (5) (B) synthetic schemes.
Supplementary Figure 1 from BRaf and MEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma
Authors: Breunig Christian , Mueller Bernadett J. , Umansky Ludmila , Wahl Kristin , Hoffmann Katrin , Lehner Frank , Manns Michael P. , Bantel Heike , Falk Christine S.
Published: April 2023

Modulation of MEK1 and ERK1/2 phosphorylation by MAPK inhibitors. Phospho-MEK1 and p-ERK1/2 at 0.5, 6, 12, 24, 48, 72 and 96h were detected in lysates of HCC cell lines HepG2 (left), Hep3B (middle) and Huh-7 (right) cells following treatment with DMSO as control solvent, 6.5µM AZD6244, U0126, sorafenib (A), PLX4720, PD0325901(B) and with 0.2, 1 or 5µM GW5074 and sunitinib (C). Values represent MFI of 30-60 beads for each kinase and time point. One of two or three representative experiments is shown.
Supplementary Table 7 - 9 from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
Authors: Mydlarz Wojciech , Uemura Mamoru , Ahn Sun , Hennessey Patrick , Chang Steven , Demokan Semra , Sun Wenyue , Shao Chunbo , Bishop Justin , Krosting Julie , Mambo Elizabeth , Westra William , Ha Patrick , Sidransky David , Califano Joseph
Published: April 2023

XLSX file - 137K, Supplementary Table 7. has-mir-21 gene target prediction (miRanda). Supplementary Table 8. has-mir-21 gene target prediction (TargetScan 4.2). Supplementary Table 9. has-mir-21 gene target prediction (PicTar).
Supplementary Figure 3 from A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2, as First-Line Monotherapy in Patients with Advanced Hepatocellular Cancer
Authors: Zhu Andrew X. , Finn Richard S. , Mulcahy Mary , Gurtler Jayne , Sun Weijing , Schwartz Jonathan D. , Dalal Rita P. , Joshi Adarsh , Hozak Rebecca R. , Xu Yihuan , Ancukiewicz Marek , Jain Rakesh K. , Nugent Francis W. , Duda Dan G. , Stuart Keith
Published: April 2023

PDF file - 76K, Fold changes in biomarker levels relative to baseline following ramucirumab infusion across study cycles. Each line indicates values for a single patient.
Supplementary Figure 1 from The Integrin Inhibitor Cilengitide Affects Meningioma Cell Motility and Invasion
Authors: Wilisch-Neumann Annette , Kliese Nadine , Pachow Doreen , Schneider Thomas , Warnke Jan-Peter , Braunsdorf Werner EK , Böhmer Frank-Dietmar , Hass Peter , Pasemann Diana , Helbing Cornelia , Kirches Elmar , Mawrin Christian
Published: April 2023

Supplementary Figure 1 - PDF file 57K, integrin mRNA expression in meningiomas
Supplementary Figure 2 from RG7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response
Authors: Yin Xuefeng , Luistro Leopoldo , Zhong Hua , Smith Melissa , Nevins Tom , Schostack Kathleen , Hilton Holly , Lin Tai-An , Truitt Theresa , Biondi Denise , Wang Xiaoqian , Packman Kathryn , Rosinski Jim , Berkofsky-Fessler Windy , Tang Jian-Ping , Pant Saumya , Geho David , Vega-Harring Suzana , DeMario Mark , Levitsky Hy , Simcox Mary
Published: April 2023

PDF file, 176K, Assessment of baseline gene expression in RG7212 responders and non-responders in qPCR array.
Supplementary Table 1 from Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245409 (XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with Advanced Solid Tumors
Authors: Papadopoulos Kyriakos P. , Tabernero Josep , Markman Ben , Patnaik Amita , Tolcher Anthony W. , Baselga José , Shi Weiliang , Egile Coumaran , Ruiz-Soto Rodrigo , Laird A. Douglas , Miles Dale , LoRusso Patricia M.
Published: April 2023

PDF file - 77KB, Supplementary Table 1. Adverse Events that Occurred in ≥10% of Patients.
Supplementary Figure 1 from RG7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response
Authors: Yin Xuefeng , Luistro Leopoldo , Zhong Hua , Smith Melissa , Nevins Tom , Schostack Kathleen , Hilton Holly , Lin Tai-An , Truitt Theresa , Biondi Denise , Wang Xiaoqian , Packman Kathryn , Rosinski Jim , Berkofsky-Fessler Windy , Tang Jian-Ping , Pant Saumya , Geho David , Vega-Harring Suzana , DeMario Mark , Levitsky Hy , Simcox Mary
Published: April 2023

PDF file, 306K, RG7212 antitumor efficacy and characterization of tumor models used to assess RG7212 antitumor efficacy.
Supplementary Figure 4 from Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245409 (XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with Advanced Solid Tumors
Authors: Papadopoulos Kyriakos P. , Tabernero Josep , Markman Ben , Patnaik Amita , Tolcher Anthony W. , Baselga José , Shi Weiliang , Egile Coumaran , Ruiz-Soto Rodrigo , Laird A. Douglas , Miles Dale , LoRusso Patricia M.
Published: April 2023

PDF file - 1779KB, Supplementary Figure 4. Effect of SAR245409 on Skin Lesions of a Ductal Breast Carcinoma Patient.
Supplementary Figure 1 from BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage
Authors: Mar Victoria J. , Wong Stephen Q. , Li Jason , Scolyer Richard A. , McLean Catriona , Papenfuss Anthony T. , Tothill Richard W. , Kakavand Hojabr , Mann Graham J. , Thompson John F. , Behren Andreas , Cebon Jonathan S. , Wolfe Rory , Kelly John W. , Dobrovic Alexander , McArthur Grant A.
Published: April 2023

Supplementary Figure 1 - PDF file 91K, Schematic diagram of experimental procedure and bioinformatic analysis
Supplementary Figure 2 from Telomere Content and Risk of Second Malignant Neoplasm in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
Authors: Gramatges Maria M. , Liu Qi , Yasui Yutaka , Okcu M. Fatih , Neglia Joseph P. , Strong Louise C. , Armstrong Gregory T. , Robison Leslie L. , Bhatia Smita
Published: April 2023

PDF file - 329K, Comparison cell types collected from three different methods, buccal brush, mouthwash, and saliva. Saliva demonstrated the highest degree of variability from sample to sample, with the mean percentage of epithelial cells and lymphocytes approximately equal.
Supplementary Figure 1 from Telomere Content and Risk of Second Malignant Neoplasm in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
Authors: Gramatges Maria M. , Liu Qi , Yasui Yutaka , Okcu M. Fatih , Neglia Joseph P. , Strong Louise C. , Armstrong Gregory T. , Robison Leslie L. , Bhatia Smita
Published: April 2023

PDF file - 283K, Comparison of Oragene to mouthwash telomere length in six individuals, with varying degrees of correlation. Samples from healthy subjects were compared to a sample from a subject with a diagnosis of dyskeratosis congenita, a short telomere syndrome (labeled BMF5).
Supplementary Materials and Methods, Tables 1 - 2 from RAS/PI3K Crosstalk and Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma
Authors: Rampias T. , Giagini A. , Siolos S. , Matsuzaki H. , Sasaki C. , Scorilas A. , Psyrri A.
Published: April 2023

PDF file - 164KB, Supplementary info for shRNA silencing of HRAS gene, supplementary table 1 (mutation detection oligos) and supplementary table 2 (qRT-PCR oligos).
Supplementary Table 2 from Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas
Authors: Pennington Kathryn P. , Walsh Tom , Harrell Maria I. , Lee Ming K. , Pennil Christopher C. , Rendi Mara H. , Thornton Anne , Norquist Barbara M. , Casadei Silvia , Nord Alexander S. , Agnew Kathy J. , Pritchard Colin C. , Scroggins Sheena , Garcia Rochelle L. , King Mary-Claire , Swisher Elizabeth M.
Published: April 2023

PDF file 51K, Cases with both germline and somatic HR mutations
Supplementary Figure 1 from Phase II Study of the Oral MEK Inhibitor Selumetinib in Advanced Acute Myelogenous Leukemia: A University of Chicago Phase II Consortium Trial
Authors: Jain Nitin , Curran Emily , Iyengar Neil M. , Diaz-Flores Ernesto , Kunnavakkam Rangesh , Popplewell Leslie , Kirschbaum Mark H. , Karrison Theodore , Erba Harry P. , Green Margaret , Poire Xavier , Koval Greg , Shannon Kevin , Reddy Poluru L. , Joseph Loren , Atallah Ehab L. , Dy Philip , Thomas Sachdev P. , Smith Scott E. , Doyle L. Austin , Stadler Walter M. , Larson Richard A. , Stock Wendy , Odenike Olatoyosi
Published: April 2023

PDF file - 339K, Flow cytometry histograms of serial levels of p-ERK and p-mTOR in patient samples.
Supplementary Table 4 from Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia
Authors: Baker Sharyn D. , Zimmerman Eric I. , Wang Yong-Dong , Orwick Shelley , Zatechka Douglas S. , Buaboonnam Jassada , Neale Geoffrey A. , Olsen Scott R. , Enemark Eric J. , Shurtleff Sheila , Rubnitz Jeffrey E. , Mullighan Charles G. , Inaba Hiroto
Published: April 2023

PDF file, 38K, Distribution of FLT3 kinase domain mutations on FLT3-ITD alleles.
Supplementary Table 6 from Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in Patients
Authors: Guinney Justin , Ferté Charles , Dry Jonathan , McEwen Robert , Manceau Gilles , Kao KJ , Chang Kai-Ming , Bendtsen Claus , Hudson Kevin , Huang Erich , Dougherty Brian , Ducreux Michel , Soria Jean-Charles , Friend Stephen , Derry Jonathan , Laurent-Puig Pierre
Published: April 2023

PDF file - 32K, PFS analysis within the French cohort.
Supplementary Table 5 from Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in Patients
Authors: Guinney Justin , Ferté Charles , Dry Jonathan , McEwen Robert , Manceau Gilles , Kao KJ , Chang Kai-Ming , Bendtsen Claus , Hudson Kevin , Huang Erich , Dougherty Brian , Ducreux Michel , Soria Jean-Charles , Friend Stephen , Derry Jonathan , Laurent-Puig Pierre
Published: April 2023

PDF file - 33K, Univariate analysis.
Supplementary Methods from Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia
Authors: Baker Sharyn D. , Zimmerman Eric I. , Wang Yong-Dong , Orwick Shelley , Zatechka Douglas S. , Buaboonnam Jassada , Neale Geoffrey A. , Olsen Scott R. , Enemark Eric J. , Shurtleff Sheila , Rubnitz Jeffrey E. , Mullighan Charles G. , Inaba Hiroto
Published: April 2023

PDF file, 76K.
Supplementary Table 2 from Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in Patients
Authors: Guinney Justin , Ferté Charles , Dry Jonathan , McEwen Robert , Manceau Gilles , Kao KJ , Chang Kai-Ming , Bendtsen Claus , Hudson Kevin , Huang Erich , Dougherty Brian , Ducreux Michel , Soria Jean-Charles , Friend Stephen , Derry Jonathan , Laurent-Puig Pierre
Published: April 2023

PDF file - 35K, Characteristics of the 2 metastatic CRC datasets used for evaluation of prediction of PFS.
Supplementary Table 1 from Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in Patients
Authors: Guinney Justin , Ferté Charles , Dry Jonathan , McEwen Robert , Manceau Gilles , Kao KJ , Chang Kai-Ming , Bendtsen Claus , Hudson Kevin , Huang Erich , Dougherty Brian , Ducreux Michel , Soria Jean-Charles , Friend Stephen , Derry Jonathan , Laurent-Puig Pierre
Published: April 2023

PDF file - 37K, Characteristics of the 4 CRC datasets used in training (KFSYSCC) and validation of the RAS model.
Supplementary Figure Legend from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
Authors: Wu Chao-Yi , Yang Li-Hua , Yang Huang-Yu , Knoff Jayne , Peng Shiwen , Lin Yi-Hsin , Wang Chenguang , Alvarez Ronald D. , Pai Sara I. , Roden Richard B.S. , Hung Chien-Fu , Wu T-C
Published: April 2023

PDF file - 89K
Supplementary Figure 8 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
Authors: Wu Chao-Yi , Yang Li-Hua , Yang Huang-Yu , Knoff Jayne , Peng Shiwen , Lin Yi-Hsin , Wang Chenguang , Alvarez Ronald D. , Pai Sara I. , Roden Richard B.S. , Hung Chien-Fu , Wu T-C
Published: April 2023

PDF file - 2157K, Characterization of different subsets of MDSCs in spleens, DLNs and tumors following the various treatments.
Supplementary Figure 7 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
Authors: Wu Chao-Yi , Yang Li-Hua , Yang Huang-Yu , Knoff Jayne , Peng Shiwen , Lin Yi-Hsin , Wang Chenguang , Alvarez Ronald D. , Pai Sara I. , Roden Richard B.S. , Hung Chien-Fu , Wu T-C
Published: April 2023

PDF file - 1272K, Characterization of the antigen-specific CD8+ T cell-mediated apoptosis of CD11b+ F4/80+ TAMs from irradiated tumors with/without intratumoral vaccination with antigenic peptide.
Supplementary Figure 4 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
Authors: Wu Chao-Yi , Yang Li-Hua , Yang Huang-Yu , Knoff Jayne , Peng Shiwen , Lin Yi-Hsin , Wang Chenguang , Alvarez Ronald D. , Pai Sara I. , Roden Richard B.S. , Hung Chien-Fu , Wu T-C
Published: April 2023

PDF file - 941K, Characterization of E7-specific CD8+ T cell activation in tumor-bearing mice treated with radiation and intratumoral vaccination with E7 peptide.
Supplementary Figure 2 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
Authors: Wu Chao-Yi , Yang Li-Hua , Yang Huang-Yu , Knoff Jayne , Peng Shiwen , Lin Yi-Hsin , Wang Chenguang , Alvarez Ronald D. , Pai Sara I. , Roden Richard B.S. , Hung Chien-Fu , Wu T-C
Published: April 2023

PDF file - 723K, Immune mediated long-term tumor protection experiment.
Supplementary Figures 1 - 18 from Metformin Sensitizes EGFR-TKI–Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal
Authors: Li Li , Han Rui , Xiao Hualiang , Lin Caiyu , Wang Yubo , Liu Hao , Li Kunlin , Chen Hengyi , Sun Fenfen , Yang Zhenzhou , Jiang Jianxin , He Yong
Published: April 2023

PDF file - 1625K, Supplementary Figure 1 IC50 values of different cell lines to TKIs under indicated conditions Supplementary Figure 2 BrdU incorporation assay for H1975 cells. Supplementary Figure 3 Expression of OCT-1 and LKB1 in different cell lines used in the current study. Supplementary Figure 4 Metformin decreases invasion and motility of erlotinib-resistant H1650-M3 cells. Supplementary Figure 5 Metformin decreases SNAIL expression in TKI-resistant human lung cancer cells. Supplementary Figure 6 Quantification of blots shown in Fig. 2E. Supplementary Figure 7 Metformin decreases IL-6 gene transcription in TKI-resistant cell lines. Supplementary Figure 8 Metformin reverses TKI resistance in IL-6 overexpressing PC-9psb cells. Supplementary Figure 9 Inhibition of IL-6 signaling is essential for metformin to overcome erlotinib resistance in H1650-M3 cells. Supplementary Figure 10 Body weight of PC-9GR xenografts Supplementary Figure 11 Serum insulin levels and glucose levels from xenografts established by PC-9GR cells. Supplementary Figure 12 Metformin in combination with gefitinib suppresses tumor growth in PC-9 xenografts Supplementary Figure 13 Metformin in combination with gefitinib increased the expression of E-cadherin and decreased the expression of Vimentin in tumor sections of PC-9 xenografts. Supplementary Figure 14 Quantification of blots in Fig. 6D. Supplementary Figure 15 Western blotting analysis of the expression of indicated markers on protein extracts obtained from harvested tumors of the gefitinib group and gefitinib+metformin group. Supplementary Figure 16 Metformin in combination with gefitinib decreases expression of phosphorylation of AKT and STAT3 in xenografts established by PC-9GR cells. Supplemental Figure 17 Metformin overcomes TKI resistance through EMT reversal and IL-6 signaling inhibition. Supplemental Figure 18 Metformin disrupts the evil axis of TGFbeta/IL-6, EMT, CSCs and TKI resistance.
Supplementary Materials and Methods and Figure Legends and Figures from Pharmacologic Inhibition of Jak2–Stat5 Signaling By Jak2 Inhibitor AZD1480 Potently Suppresses Growth of Both Primary and Castrate-Resistant Prostate Cancer
Authors: Gu Lei , Liao Zhiyong , Hoang David T. , Dagvadorj Ayush , Gupta Shilpa , Blackmon Shauna , Ellsworth Elyse , Talati Pooja , Leiby Benjamin , Zinda Michael , Lallas Costas D. , Trabulsi Edouard J. , McCue Peter , Gomella Leonard , Huszar Dennis , Nevalainen Marja T.
Published: April 2023

PDF file, 966K, Supplementary Figure 1. The growth of CWR22Pc cells is down-regulated by bicalutamide. ; Supplementary Figure 2. Stat5a/b, but not Stat3, is persistently activated in CWR22Rv1 and CWR22Pc cells. Supplementary Figure 3. Inhibition of Stat5a/b, but not Stat3, significantly decreases the fraction of viable CWR22Rv1 and CWR22Pc cells. ; Supplementary Figure 4. AZD1480 induces caspase-3 activity to the same extent as genetic knockdown of Jak2 or Stat5 by shRNA. ; Supplementary Figure 5. AZD1480-treated mice maintain higher body weights than docetaxeltreated mice. ; Supplementary Figure 6. AZD1480 does not affect levels of nuclear Stat3 in CWR22Pc tumors. Supplementary Figure 7. AZD1480 induces apoptotic cell death in CWR22Pc xenograft tumors. ; Supplementary Figure 8. AZD1480 down-regulates Stat5-target gene Bcl-Xl expression in CWR22Rv1 cells in culture. ; Supplementary Figure 9. AZD1480 regulates the expression of Stat5 target genes Bcl-Xl and Ecadherin in CWR22Pc xenograft tumors.
Supplementary Table 1 from EZH2 Protein Expression Associates with the Early Pathogenesis, Tumor Progression, and Prognosis of Non–Small Cell Lung Carcinoma
Authors: Behrens Carmen , Solis Luisa M. , Lin Heather , Yuan Ping , Tang Ximing , Kadara Humam , Riquelme Erick , Galindo Hector , Moran Cesar A. , Kalhor Neda , Swisher Stephen G. , Simon George R. , Stewart David J. , Lee J. Jack , Wistuba Ignacio I.
Published: April 2023

PDF file 87K, Summary of multivariate analysis of outcome in lung adenocarcinoma patients by combined expression of EZH2 and TTF-1
Supplementary Figure 2 from The PDGFRβ–AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors
Authors: Juliachs M. , Muñoz C. , Moutinho C.A. , Vidal A. , Condom E. , Esteller M. , Graupera M. , Casanovas O. , Germà J.R. , Villanueva A. , Viñals F.
Published: April 2023

PDF file - 431K, Supplementary figure 2 shows PDGFRbeta and PDGF-BB overexpression in SuSaR compared with SuSaS.
Supplementary Figure 5 from Synergistic Antitumor Activity of Cetuximab and Namitecan in Human Squamous Cell Carcinoma Models Relies on Cooperative Inhibition of EGFR Expression and Depends on High EGFR Gene Copy Number
Authors: De Cesare Michelandrea , Lauricella Calogero , Veronese Silvio Marco , Cominetti Denis , Pisano Claudio , Zunino Franco , Zaffaroni Nadia , Zuco Valentina
Published: April 2023

PDF file - 740K, Effects of namitecan and SN-38 alone or plus cetuximab on EGFR protein expression and phosphorylation at ser1046/47 and on p38 MAPK activation.
Supplementary Figure 2 from Synergistic Antitumor Activity of Cetuximab and Namitecan in Human Squamous Cell Carcinoma Models Relies on Cooperative Inhibition of EGFR Expression and Depends on High EGFR Gene Copy Number
Authors: De Cesare Michelandrea , Lauricella Calogero , Veronese Silvio Marco , Cominetti Denis , Pisano Claudio , Zunino Franco , Zaffaroni Nadia , Zuco Valentina
Published: April 2023

PDF file - 38K, Antiproliferative activity of cetuximab or namitecan and Combination Index (CI) relative to the 72 h combined treatment between namitecan and IC20 values of cetuximab.
Supplementary Figure 1 from Synergistic Antitumor Activity of Cetuximab and Namitecan in Human Squamous Cell Carcinoma Models Relies on Cooperative Inhibition of EGFR Expression and Depends on High EGFR Gene Copy Number
Authors: De Cesare Michelandrea , Lauricella Calogero , Veronese Silvio Marco , Cominetti Denis , Pisano Claudio , Zunino Franco , Zaffaroni Nadia , Zuco Valentina
Published: April 2023

PDF file - 65K, Efficacy of irinotecan in combination with cetuximab against A431, A431/TPT and Caski xenograft tumor models.
Supplementary Figure 7 from Human Breast Cancer Cells Harboring a Gatekeeper T798M Mutation in HER2 Overexpress EGFR Ligands and Are Sensitive to Dual Inhibition of EGFR and HER2
Authors: Rexer Brent N. , Ghosh Ritwik , Narasanna Archana , Estrada Mónica Valeria , Chakrabarty Anindita , Song Youngchul , Engelman Jeffrey A. , Arteaga Carlos L.
Published: April 2023

Supplementary Figure 7 - PDF file 282K, Inhibition of P-Akt in xenografts treated with trastuzumab plus/minus lapatinib
Supplementary Figure 2 from Measles Virus Vaccine–Infected Tumor Cells Induce Tumor Antigen Cross-Presentation by Human Plasmacytoid Dendritic Cells
Authors: Guillerme Jean-Baptiste , Boisgerault Nicolas , Roulois David , Ménager Jérémie , Combredet Chantal , Tangy Frédéric , Fonteneau Jean-François , Gregoire Marc
Published: April 2023

AVI file - 13330K, Supplemental Figure 2: absence of infection of pDC by MV-eGFP. pDC were cocultured with MV-eGFP (MOI=1) in the presence of IL-3. Fluorescence microscopy video-recording was performed with a picture taken every 15 minutes with a time lapse confocal microscope (Nikon). One cell becomes infected after 12 hours.
Supplementary Fig S4 from Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
Authors: Allard Bertrand , Pommey Sandra , Smyth Mark J. , Stagg John
Published: April 2023

Supplementary Fig S4 - PDF file 62K, Figure S4. Growth rates of carcinogen-induced tumors treated with anti-CD73/anti-PD-1 mAbs
Supplementary Fig S3 from Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
Authors: Allard Bertrand , Pommey Sandra , Smyth Mark J. , Stagg John
Published: April 2023

Supplementary Fig S3 - PDF file 111K, Figure S3. CD73 expression levels after anti-CD73 mAb therapy
Supplementary Methods, Figures 1 - 3, Tables 1 - 4 from Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer
Authors: Beaver Julia A. , Jelovac Danijela , Balukrishna Sasidharan , Cochran Rory L. , Croessmann Sarah , Zabransky Daniel J. , Wong Hong Yuen , Valda Toro Patricia , Cidado Justin , Blair Brian G. , Chu David , Burns Timothy , Higgins Michaela J. , Stearns Vered , Jacobs Lisa , Habibi Mehran , Lange Julie , Hurley Paula J. , Lauring Josh , VanDenBerg Dustin A. , Kessler Jill , Jeter Stacie , Samuels Michael L. , Maar Dianna , Cope Leslie , Cimino-Mathews Ashley , Argani Pedram , Wolff Antonio C. , Park Ben Ho
Published: April 2023

PDF file - 395KB, Figure S1. Pre-surgery plasma ddPCR analysis for PIK3CA mutations. Figure S2. Positive and negative controls for droplet thresholds and counts. Figure S3. Lower Limit of Detection for PIK3CA Exon 9. Supplementary Table S1: Primers used to amplify and sequence FFPE specimens. Supplementary Table S2: Primers and probes used for ddPCR on FFPE samples. Supplementary Table S3: Primers and probes for ddPCR of plasma DNA. Supplementary Table S4: Fractional abundance and 95% confidence intervals of positive ptDNA samples.
Supplementary Figure 1 from Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner
Authors: Palmieri Diane , Duchnowska Renata , Woditschka Stephan , Hua Emily , Qian Yongzhen , Biernat Wojciech , Sosińska-Mielcarek Katarzyna , Gril Brunilde , Stark Andreas M. , Hewitt Stephen M. , Liewehr David J. , Steinberg Seth M. , Jassem Jacek , Steeg Patricia S.
Published: April 2023

PDF file - 67KB, MGMT overexpression in 231-BR-EGFP cells increases sensitivity to temozolomide in vitro.
Supplementary Table 1 from A Phase I Study of the HSP90 Inhibitor Retaspimycin Hydrochloride (IPI-504) in Patients with Gastrointestinal Stromal Tumors or Soft-Tissue Sarcomas
Authors: Wagner Andrew J. , Chugh Rashmi , Rosen Lee S. , Morgan Jeffrey A. , George Suzanne , Gordon Michael , Dunbar Joi , Normant Emmanuel , Grayzel David , Demetri George D.
Published: April 2023

Supplementary Table 1 - PDF file 74K, Mean (SD) pharmacokinetic parameters of IPI-504 and metabolites on Cycle 1, Day 1