bluuebunny/crossref_metadata_2025 huggingface dataset:
PENINGKATAN KAPASITAS KADER POSYANDU MELALUI PELATIHAN MENDETEKSI STUNTING DI DESA RASAU JAYA KECAMATAN RASAU JAYA KABUPATEN KUBU RAYA
Authors: Desi Desi , Sulistyaningsih Ikawati , Jahri Muhammad , Nopriantini Nopriantini , Petrika Yanuarti , Ginting Martinus , Rafiony Ayu , Dahliansyah Dahliansyah , Ulfa Mauliana
Published: August 2024

Keterbatasannya tenaga kesehatan di Indonesia menyebabkan daya cakup pelayanan kesehatan belum optimal. Sehingga strategi pembangunan partisipatif adalah cara yang efektif untuk menangani masalah stunting ini. Dikatakan partisipatif karena bukan hanya pemerintah yang harus sadar dan beraksi, namun juga masyarakat harus sadar dan bergerak untuk menangani masalah ini. Salah satunya adalah dengan pemberdayaan kader kesehatan di posyandu Kasus stunting sering terjadi karena penyakit ini sering kali tidak disadari dan tidak diketahui oleh masyarakat. Oleh karena itu, masyarakat perlu diberdayakan untuk mengenali dan memahami tanda-tanda stunting. Dengan mengetahui karakteristik stunting sejak dini, penanganan dapat segera dilakukan untuk mencegah komplikasi yang lebih serius.Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk memberdayakan masyarakat, melalui kader posyandu dalam penanganan dan pencegahan masalah stunting di wilayah Puskesmas Rasau Jaya. Selain itu menerapkan model pemberdayaan masyarakat yang lebih partisipatif dalam penanganan dan pencegahan masalah stunting di wilayah Puskesmas Rasau Jaya. Metode kegiatan pengabdian masyarakat yang akan dilakukan berupa peningkatan kapasitas kader dalam melakukan kegiatan pendampingan. Adapun metode peningkatan kapasitas kader adalah dengan memberikan pelatihan, refresing kader, sosialisasi dan praktek dalam meningkatkan pengetahuan dan keterampilan kader pendampingan. Upaya peningkatan pengetahuan dan kesadaran mengenai stunting terhadap kesehatan dan dampaknya pada masa depan, menambah wawasan tentang upaya pencegahan dan penanganan stunting. Hasil kegiatan pengabdian di Desa Rasau Jaya Tiga, Kubu Raya, menunjukkan bahwa pemberdayaan kader posyandu berhasil meningkatkan pengetahuan tentang penanggulangan stunting. Kader mampu antropometri dan menentukan status anemia ibu hamil lebih baik, mencerminkan komitmen dalam mendukung pencegahan stunting sesuai tujuan pengabdian masyarakat.
SIFAT ORGANOLEPTIK DAN NILAI GIZI PUDING U-BANSOY (ULI BANANA SOYA) SEBAGAI ALTERNATIF SELINGAN TINGGI KALIUM DAN ISOFLAVON
Authors: Nurhotimah Enung , Aeni Muna Nur , Gumilar Mulus , Fitria Mona , Judiono Judiono , Mulyo Gurid Pramintarto Eko
Published: August 2024

Uli bananas contain higher potassium than other types of bananas. Soybeans can help lower blood pressure in hypertensive patients through potassium content and antioxidant activity, as shown by isoflavones. This study aimed to determine the organoleptic properties and nutritional value of U-Bansoy Pudding with soybean and banana formulations as an alternative high-potassium and isoflavone snacks for hypertensive patients. The research design used an experimental study design using a Complete Experimental Design (RAL) consisting of one factor in the form of 3 types of soybean and banana balance, namely 25%:75%, 50%:50%, 75%:25%. The research method used an organoleptic test with a hedonic test of 7 numerical scale on 30 moderately trained panelists. The results of  U-Bansoy Pudding organoleptic test on the color and texture that the panelists liked the most was a 50%:50% balance. U-Bansoy pudding organoleptic test results on the aroma that the panelists most liked were the balance of 25%:75% and 50%:50%, while the results of the organoleptic test of U-Bansoy pudding on the taste and overall (overall) balance of 25%:75% were the most preferred by the panelists. By consuming one serving of U-Bansoy Pudding with a balance of 25%:75% is enough to contribute as an alternative distraction for hypertensive patients with 185.95 grams of energy, 8.74 grams of protein, 3.64 grams of fat, 34.2 grams of carbohydrates, 533.14 mg of potassium and 30.9 mg of isoflavones. U-Bansoy pudding can be used as an alternative snack for hypertensive patients who need a diet high in potassium and isoflavones.
Poésie Grande Guerre: como a história digital desafiou cânones no centenário da Primeira Guerra mundial
Authors: Thomaz Julia
Published: August 2024

Diante da exclusão da poesia francesa da Primeira Guerra mundial da periodização literária, da historiografia e da memória coletiva, o projeto Poésie Grande Guerre se serviu da efervescência científica dos anos do centenário (2024-2018) para criar uma base de dados pública, relacionando poetas, produções literárias e experiências da guerra. Rejeitando a ideia de estabelecer um cânone análogo ao que existe nos países de língua inglesa, essa base de dados se inspira nas abordagens big data e da linguística de corpus para oferecer uma visão geral da poesia da Grande Guerra como uma categoria social que descreve uma prática cultural difusa. Examinando Poésie Grande Guerre desde a sua construção, e principalmente o engajamento em torno desse projeto nas redes sociais, o presente artigo se divide em três partes. A primeira, consagrada à historiografia, demonstra como a poesia foi excluída das duas primeiras configurações da historiografia da Primeira Guerra mundial na França e como, apesar de ser aceita na configuração mais recente, o elemento digital fornecido pelo centenário foi o catalisador para um estudo desse corpus. A segunda parte, teórica, examina como iniciativas digitais de inscrevem em um movimento mais amplo de questionamento não só de cânones específicos mas também da canonização em geral. Finalmente, a terceira parte, de natureza prática, demonstra como os processos de construção do modelo de dados e de engajamento com o público nas redes sociais foram, mais do que uma técnica ao serviço da produção de um conhecimento que lhe seria externo, fundamentais para pensar a poesia da Grande Guerra. Assim, o estudo argumentará que ferramentas digitais desafiam os cânones literários e historiográficos, e movem portanto a historiografia da Primeira Guerra mundial em direção a uma poética histórica verdadeiramente pública e interdisciplinar.
Cirurgiões militares e seus requerimentos à esfera régia: o uso dos regimentos militares como espaço de mobilidade social na capitania de Minas Gerais (1771/1807)
Authors: Pereira Costa Ana Paula , Campos Ferreira Pâmela
Published: August 2024

O presente artigo busca levantar requerimentos e petições de cirurgiões de distintos Regimentos Militares na capitania de Minas Gerais, que foram encaminhados à esfera monárquica entre o período de 1771 a 1807. Primeiramente, é preciso destacar que o acervo documental a ser utilizado é composto por requerimentos existentes no Arquivo Histórico Ultramarino (AHU). Trabalharemos, portanto, com a chave empírica representada por esses requerimentos/petições, pois acreditamos na hipótese de que cirurgiões ligados às hierarquias militares se utilizavam desse espaço como meio de ascenderem socialmente.
Safety and Tolerability of Adipose-Derived Mesenchymal Stem Cell (ADR-001) Therapy for IgA Nephropathy
Authors: Tanaka Akihito , Furuhashi Kazuhiro , Fujieda Kumiko , Horinouchi Asuka , Maeda Kayaho , Saito Shoji , Mimura Tetsushi , Saka Yosuke , Naruse Tomohiko , Ishimoto Takuji , Kato Noritoshi , Kosugi Tomoki , Kinoshita Fumie , Kuwatsuka Yachiyo , Nakai Yasuhiro , Maruyama Shoichi
Published: August 2024

Key Points

IgA nephropathy often requires KRT.

Mesenchymal stem cells offer clinical benefits.

Adipose-derived mesenchymal stem cells are safe and tolerable.

Background

IgA nephropathy (IgAN) often requires KRT because of its refractoriness and because corticosteroids pose infection risks. However, mesenchymal stem cells offer clinical benefits because of their regenerative and immunomodulatory properties. This prospective clinical trial assessed the safety and tolerability of adipose-derived mesenchymal stem cell (ASC) therapy and evaluated its therapeutic efficacy.

Methods

This phase 1 study included adult patients with refractory IgAN that was difficult to treat with traditional therapies. ASC therapy comprising one intravenous dose of 1×108 cells was administered to three to six patients in Cohort 1. The same intravenous dose was administered twice with a 2-week interval to six patients in Cohort 2. Heparin was administered simultaneously. This study continued for 52 weeks, and the primary end points were safety and tolerability during the 6-week period after treatment administration. Secondary end points included adverse events and efficacy measures such as clinical remission, partial remission, urine protein remission, hematuria remission, time to remission, changes in the urine protein and hematuria levels, and changes in the eGFR.

Results

The three patients in Cohort 1 and six patients in Cohort 2 who received ASC therapy achieved the primary end points. No severe adverse clinical events were observed. Therefore, the safety and tolerability of ASCs were confirmed. Improvements, such as significantly decreased kidney damage markers and urinary protein levels, were observed immediately after ASC administration.

Conclusions

The safety and tolerability of ASCs are acceptable for patients with IgAN.

Clinical Trial registry name and registration number:

This trial was registered with the Japan Registry of Clinical Trials (jRCT2043200002; registration date: April 14, 2020) and ClinicalTrials.gov (NCT04342325; registration date: April 13, 2020).
Acute Kidney Injury Associated with Anticancer Therapies: Small Molecules and Targeted Therapies
Authors: Kala Jaya , Joseph Teresa , Pirovano Marta , Fenoglio Roberta , Cosmai Laura
Published: August 2024

Molecular targeted therapy has revolutionized cancer treatment by significantly improving patient survival compared with standard conventional chemotherapies. The use of these drugs targets specific molecules or targets, which block growth and spread of cancer cells. Many of these therapies have been approved for use with remarkable success in breast, blood, colorectal, lung, and ovarian cancers. The advantage over conventional chemotherapy is its ability to deliver drugs effectively with high specificity while being less toxic. Although known as “targeted,” many of these agents lack specificity and selectivity, and they tend to inhibit multiple targets, including those in the kidneys. The side effects usually arise because of dysregulation of targets of the inhibited molecule in normal tissue. The off-target effects are caused by drug binding to unintended targets. The on-target effects are associated with inhibition toward the pathway reflecting inappropriate inhibition or activation of the intended drug target. Early detection and correct management of kidney toxicities is crucial to preserve kidney functions. The knowledge of these toxicities helps guide optimal and continued utilization of these potent therapies. This review summarizes the different types of molecular targeted therapies used in the treatment of cancer and the incidence, severity, and pattern of nephrotoxicity caused by them, with their plausible mechanism and proposed treatment recommendations.
PENERAPAN MANAJEMEN PESERTA DIDIK PADA SEKOLAH MENENGAH ATAS
Authors: Cindy Agustin Hanivia , Aisyah Viana Putri
Published: August 2024

Learner management can function as a platform that promotes growth, quality, and achievement in educational institutions. Students are effectively supervised and controlled to ensure that educational institutions can accurately assess the progress of students' achievements. Student management is the administrative process that encompasses all actions related to students, starting from their enrollment in school until their graduation. This process involves many tasks such as coaching, planning, evaluation, and transfer. The objective of this study is to ascertain the administrative procedures involved in managing high school students. The study methodology employed is descriptive qualitative, utilizing a phenomenon-oriented research technique. The research employs data gathering approaches such as observation, interviews, and documentation. The research findings indicate that nearly all schools have successfully implemented student management systems that are tailored to the unique characteristics of each school. The student management process encompasses several tasks such as student planning, student acceptance and selection, student grouping, attendance and absence management, student evaluation, extracurricular activities and OSIS, management of student transfers and dropouts, as well as handling graduates and alumni.
MANAJEMEN STRATEGI PENDIDIKAN DALAM MENINGKATKAN KUALITAS GURU DI SD NEGERI 1 BUMI ARJO KECAMATAN LEMPUING KABUPATEN OKI
Authors: Yuliana Yuliana , Harapan Edi , Eddy Syaiful
Published: August 2024

This study aims to analyze and describe the planning of strategies to improve the quality of teachers of SD Negeri 1 Bumiarjo, analyze and describe the implementation of strategies to improve the quality of teachers of SD Negeri 1 Bumiarjo, analyze and describe the organization of strategies to improve the quality of teachers of SD Negeri 1 Bumiarjo, analyze and describe the obstacles faced in improving the quality of teachers of SD Negeri 1 Bumiarjo. This type of research is descriptive qualitative using SWOT analysis. Data collection techniques were interviews, observation, and documentation. The data sources were supervisors, principals, and teachers. Data analysis techniques are data reduction, data presentation and data verification. The results of this study show that: 1) The planning of educational strategies to improve teacher quality at SD Negeri 1 Bumiarjo has been well implemented; 2) Implementation of strategies to improve the quality of teachers at SD Negeri 1 Bumi Arjo has been implemented well; 3) The organization of strategies to improve the quality of teachers at SD Negeri 1 Bumi Arjo has been carried out well; 4) The obstacles faced in improving the quality of teachers at SD Negeri 1 Bumiarjo can be overcome well. The results of the SWOT analysis show that there are internal factors that are the strengths and weaknesses of the strategic planning of education to improve the quality of teachers at SD Negeri 1 Bumiarjo.
Energy Conversion by Helical Hydrokinetic Turbine in A Pipe
Authors: Türker Mehmet Salih , Yüce Mehmet İshak
Published: August 2024

Hydrokinetic turbines are mechanisms designed for the purpose of utilizing the kinetic energy present in the movement of water bodies like rivers, tidal currents, or ocean currents, and transforming it into electrical power. These turbines’ function based on a principle akin to that of wind turbines; however, they are positioned underwater to harness the energy of the water flow. This study focuses on the fundamentals of hydrokinetic turbines and presents existing research. Additionally, simulations have been conducted to observe how the hydrokinetic turbine responds hydrodynamically inside a pipe. A three-bladed vertical-axis helical hydrokinetic turbine was installed within a circular conduit and subjected to analysis under varying flow conditions. The k-ω SST turbulence model was employed in the analyses. The results indicated that increasing the turbine's angular velocity initially raises the torque and the power coefficient until a peak is reached, after which the power coefficient decreases. The highest power coefficient was observed at a flow velocity of 2 m/s. Moreover, consistent with previous studies, the hydrokinetic turbine within the pipe surpassed the Betz limit.
CONCEPTUAL ASPECTS OF STUDYING OF REGIONAL SOCIO-ECONOMIC SYSTEMS’ RESILIENCE
Authors: Быстров В.В. , Халиуллина Д.Н.
Published: August 2024

Работа посвящена теоретическим вопросам исследования региональных социально-экономических систем с позиции концепции жизнеспособности (resilience). Авторы предпринимают попытку систематизировать актуальное состояние изучения жизнеспособности сложных систем и критических инфраструктур. Рассматривается многообразие терминов, связанных с понятием «жизнеспособность систем», сделан вывод о наличии дублирования терминов. На основе анализа стадий (фаз, этапов) жизненного цикла предложено описание структуры и каждого из основных этапов жизненного цикла жизнеспособности системы. Приводится классификация видов жизнеспособности, полученная в ходе анализа открытых источников информации (около 150 научных публикаций и отчетной документации по научно-исследовательским проектам), что позволило обосновать отсутствие единого универсального методологического фундамента для изучения жизнеспособности с общесистемной позиции. Рассматриваются методологии изучения жизнеспособности технических (природно-промышленных) и социально-экономических систем, сделан вывод о разнообразии применяемых методологических средств для исследования жизнеспособности сложных систем. Развивая идею, что жизнеспособность социально-экономической системы нужно рассматривать в соответствии с ее масштабом, авторами в ходе анализа систематизированы выявленные определения жизнеспособности региональных социально-экономических систем по их масштабу. Авторами сформулировано определение жизнеспособности региональной социально-экономической системы класса «Бизнес-Сообщество-Власть».

The work is devoted to theoretical issues in the study of regional socio-economic systems in the resilience context. The authors make an attempt to systematize the current state of studying the complex systems and critical infrastructures resilience. The variety of “system resilience” concept terms is considered, and a conclusion is made about the terms duplication presence. Based on the life cycle stages (phases) analysis, a description of the structure and each stage is proposed. A resilience types’ classification is presented, according to the open information sources analysis (about 150 scientific publications and reporting documentation on research projects), which made it possible to justify the lack of a unified universal methodological foundation for studying resilience from a system-wide position. Methodologies for studying the technical (natural-industrial) and socio-economic systems resilience are considered, and a conclusion is drawn about the variety of methodological tools used to study the complex systems resilience. Developing the idea that the socio-economic system resilience should be considered in accordance with its scale; in the course of the analysis, the authors systematized the identified regional socio-economic systems resilience definitions according to their scale. The authors formulated a definition of the “regional Business-Community-Authority socio-economic system resilience”.
ISSUES OF PROFESSIONAL STANDARDS APPLICATION IN UNIVERSITY HR MANAGEMENT
Authors: Антипина И.О.
Published: August 2024

В статье представлен опыт применения профессиональных стандартов в управлении персоналом государственного российского университета – от этапа внедрения в 2014 - 2018 годах до настоящего времени. Рассматривается проблема поиска механизмов оптимизации работы кадровой службы вуза с большим массивом профессиональных стандартов. На первом этапе эффективным механизмом организации работы стали планы-графики внедрения профессиональных стандартов на период 2016 - 2019 годов. В публикации описана структура и примерное содержание такого документа. Для оптимизации работы на современном этапе автор предлагает вести и актуализировать реестр профессиональных стандартов организации. В статье предложена примерная структура такого реестра. Кроме того, для своевременного отслеживания утверждения новых профстандартов, автор рекомендует вносить в предлагаемый реестр профессиональные стандарты, находящиеся в разработке или в процессе пересмотра, которые планируется внедрить в организации после их издания. В ситуации постоянного обновления профессиональных стандартов необходимо создание в вузе гибкой системы нормативного регулирования процессов управления персоналом. Основой этой системы должна стать современная методология национальной системы квалификации России и стратегия развития организации.

The article presents the experience of professional standards’ applying in HRM at a Russian state university: from the implementation stage in 2014-2018 to the present. The problem of finding mechanisms for optimizing the university’s staff service work with a large array of professional standards is considered. At the first stage, professional standards implementation schedules for the period 2016-2019 became an effective mechanism for organizing work. The publication describes the structure and approximate content of such a document. To optimize work at the present stage, the author proposes to maintain and update the register of professional standards in the organization. The article proposes an approximate structure of such a register. In addition, in order to timely track the approval of new professional standards, the author recommends adding to the proposed register professional standards that are under development or in the revision process, which are planned to be implemented in organizations after their publication. In a situation of professional standards’ constant updating, it is necessary to create a flexible regulation system of HRM processes at the university. This system basis should be the modern methodology of the Russian national qualification system and the organization’s development strategy.
MECHANISM FOR THE STRATEGY DEVELOPMENT AND IMPLEMENTATION OF THE SERVICE SECTOR INNOVATIVE DEVELOPMENT
Authors: Тхор Е.С. , Тхор С.А. , Макарова Е.И.
Published: August 2024

В статье рассмотрен механизм разработки и реализации стратегии инновационного развития сферы услуг. Представлена стратегия инновационного развития, которая описывается как последовательная смена явлений, состояний, совокупности действий для достижения определенного результата – повышение качества и технологичности услуг. Для организационно-методического обеспечения процесса формирования и реализации стратегии инновационного развития предложен механизм разработки и реализации стратегии инновационного развития предприятий сферы услуг, состоящий из последовательных этапов. Предприятиям сферы услуг целесообразен переход на новую интегрированную систему управления инновационным процессом как самостоятельным объектом управления. В условиях цифровой стратегии развития общества, совершенствования информационного обеспечения выделены несколько подходов к оценке эффективности перспектив инновационного развития сферы услуг. Предложен механизм разработки и реализации стратегии инновационного развития сферы услуг в контексте применения кластерных технологий. Описаны отличительные черты кластерного подхода, характеризующегося возникновением положительных эффектов: эффекта масштаба, эффекта охвата и эффекта синергии. Предложено применение метода экспертных оценок для анализа эффекта синергии. Отмечено, что предприятиям сферы услуг целесообразен переход на новую интегрированную систему управления инновационным процессом как самостоятельным объектом управления.

The article considers the development and implementation mechanism of the innovative development strategy in the service sector. The innovative development strategy is presented, which is described as a sequential change of phenomena, states, and a set of actions to achieve a certain result – improving the services quality and manufacturability. For organizational and methodological support of the innovative development strategy’s formation and implementation process, a mechanism for the innovative development strategy’s development and implementation in the service sector, consisting of successive stages, is proposed. In the digital strategy context for the society development and the information support improvement, several approaches to assessing the prospects effectiveness for service sector innovative development have been identified. A mechanism for the strategy development and implementation for the service sector innovative development in the context of the cluster technologies usage is proposed. The distinctive features of the cluster approach, characterized by the emergence of positive effects: scale effect, scope effect and synergy effect, are described. The use of the expert assessment method to analyze the synergy effect is proposed. It is noted that it is expedient for service sector enterprises to switch to a new integrated management system of the innovation process as an independent management object.
ALGORITHM FOR ASSESSING STUDENTS' RESEARCH COMPETENCIES
Authors: Патутина С.Ю. , Пеша А.В.
Published: August 2024

Управление научно-исследовательским потенциалом молодежи сегодня самая актуальная задача для нашей страны. Для эффективного управления очень важно разработать типовую систему мониторинга и оценки научно-исследовательской деятельности организаций и предприятий различных сфер деятельности на всех уровнях их существования. Основой проведения исследования послужил системный подход, связанный с применением метода моделирования, что позволило комплексно изучить и воспроизвести строение и свойства и качества алгоритма оценки научно-исследовательских компетенций студентов. На основе проведенного анализа разработан и представлен авторский алгоритм оценки научно-исследовательского потенциала студента и специалиста, раскрытый в трех взаимосвязанных моделях оценки. Полученные результаты лягут в работу проведения эмпирического исследования эффективности формирования научно-исследовательских компетенций студентов вузов при осуществлении ими профессиональной деятельности после окончания университета.

Managing the research potential of young people today is the most urgent task for our country. For effective management, it is very important to develop a standard system for monitoring and evaluating the research activities of organizations and enterprises in various fields of activity at all levels of their existence. The basis of the research was a systematic approach associated with the use of the modeling method, which allowed to comprehensively study and reproduce the structure and properties and qualities of the algorithm for evaluating students' research competencies. Based on the analysis, the author's algorithm for evaluating the research potential of a student and a specialist, disclosed in three interrelated assessment models, is developed and presented. The results obtained will form the basis of an empirical study of the effectiveness of the formation of research competencies of university students in their professional activities after graduation.
Effect of Dexmedetomidine in Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Study
Authors: Zhikharev V. A. , Bushuev A. S. , Arutyunyan R. A. , Porhanov V. A.
Published: August 2024

Background: One-lung ventilation is used to improve surgical visualization and facilitate thoracoscopic manipulations; however, it induces ventilation/perfusion mismatch, exacerbating the inflammatory response that causes hypoxemia in the perioperative period. Opioid analgesics are the main analgesic drugs used during video-assisted thoracoscopic surgery (VATS), but their use is associated with adverse effects and higher risk of respiratory complications. Corrective measures to eliminate hypoxemia, reduce the inflammatory response, control pain, and minimize opioid-induced adverse effects are crucial in thoracic surgery.

Objective: To study the efficacy of dexmedetomidine in reducing lung damage and postoperative complications after VATS.

Materials and methods: We examined 100 patients who underwent lobectomy via a thoracoscopic approach. The patients were grouped based on anesthetic management: group 1 (n = 50) with intraoperative dexmedetomidine and group 2 (n = 50) without it. We determined the level of pro-inflammatory cytokines IL-6, IL-8, and TNF and calculated PaO2/FiO2 and A-aDO2. We also assessed the postoperative pain intensity, need for trimeperidin promedol and tramadol, and incidence of postoperative complications.

Results: During one-lung ventilation, patients from group 1 had higher PaO2/FiO2 values (P = .025). The A-aDO2 value was higher in group 2 (P = .006). After surgery, we found differences in the content of TNF and IL-8 (P < .001). Twenty-four hours after surgery, we recorded a more significant prevalence of the studied cytokines in group 2 (P < .001). There were no significant differences in the pain dynamics on the first postoperative day (P > .05). Opioid analgesics were less needed in group 1 than in group 2 (P < .001). The incidence of postoperative complications did not differ significantly.

Conclusions: Dexmedetomidine in thoracic surgery improves the oxygenation and reduces the percentage of intrapulmonary shunting by inhibiting the release of pro-inflammatory cytokines. In the postoperative period, dexmedetomidine reduces the need for opioid analgesics, but does not affect the pain level or incidence of complications.
Peculiarities of Early Surgical Treatment of Patients With Deep Burns Using Biological Dressings
Authors: Bogdanov S. B. , Karakulev A. V. , Afanasov I. M. , Mukhanov M. L. , Zaitseva S. L. , Dutov V. S.
Published: August 2024

Background: Early necrosectomy with immediate or delayed skin grafting is the gold standard in treatment of burn injuries. Despite all advances in active surgical treatment of burn patients, the optimal time of necrosectomy as well as methods and timing of skin grafting remain the subject of debate among burn surgeons. Reliability and practicality of methods to determine the viability of affected skin tissues act as a limiting factor to advances in surgical strategies for early treatment of burn injuries.

Objective: To improve methods of early surgical treatment of patients with deep burns using biological dressings.

Materials and methods: Our study analyzed treatment outcomes of 34 patients (age, 18 to 60 years) diagnosed with third-degree burn wounds of different localizations involving 5%-20% of body surface area (according to ICD-10). Group 1 included 18 (53%) patients who underwent skin grafting right after surgical removal of necroses; biological dressings (Chitopran) were applied. Group 2 comprised 16 (47%) patients who also underwent early surgical treatment (autografting), but autografts were covered with synthetic dressings (Voskopran).

Results: We found that in group 1 the average time to engraftment after skin grafting followed by Chitopran application was 5.0 (5.0-6.0) days. In group 2, the average time to engraftment after skin grafting followed by Voskopran application was 6.0 (6.0-6.3) days. The statistical data demonstrated that biological dressings had an advantage over synthetic ones in terms of time to engraftment.

Conclusions: We can conclude that biological dressings have an advantage over synthetic ones in surgical treatment of partial thickness and deep burn wounds.
Immunotherapy Prior to a Liver Transplant: Literature Review and a Case Report of Hepatocellular Carcinoma With BRCA1 Mutation
Authors: Kostrygin N. E. , Chumachenko D. S.
Published: August 2024

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality worldwide. The effectiveness of its standard treatment in some cases remains poor.

We report a case of a patient with Barcelona Clinic Liver Cancer stage C cryptogenic HCC whose life duration was 26 months after diagnosis.

A 46-year-old woman, a former smoker, presented with elevated alpha-fetoprotein and a left liver lobe mass diagnosed as HCC. Pulmonary nodules (presumably metastatic) were previously found and remained stable. The left lobe of the liver was resected. Intrahepatic recurrence developed 1.5 months later. Lenvatinib+pembrolizumab therapy was prescribed and later switched to olaparib following the detection of somatic and germline BRCA1 mutation. The patient underwent a liver transplant and was prescribed a combination of tacrolimus and everolimus, later supplemented with extracorporeal photopheresis. Pulmonary nodules that were found to be metastases were treated with radiation therapy. A lethal outcome occurred 21.3 months after the transplant.

The first literature review related to this case report discusses the problem of neoadjuvant immune checkpoint inhibitor therapy prior to a liver transplant. More than 100 patients have been described in 40 articles and 113 patients, in 2 multicenter studies. Although 16.7%-27.7% of patients developed rejection, such approach may be effective in downstaging the disease.
Sinonasal Tumors: Clinical and Morphological Characteristics and Differential Diagnosis
Authors: Prokhorova A. I. , Samoylova S. I. , Levendyuk O. A. , Didenko M. I. , Reshetov I. V. , Sukortseva N. S. , Samoilova O. V. , Demura T. A.
Published: August 2024

Malignant sinonasal tumors are rare and account for 1% of all neoplasms. Most of these carcinomas are poorly differentiated or undifferentiated tumors. Due to overlapping features, both young and experienced physicians encounter difficulties in their diagnosis. We present 2 cases of 2 tumors of the sinonasal tract, which belong to small round blue cell tumors: sinonasal small cell neuroendocrine tumor and esthesioneuroblastoma.
Factors Affecting Treatment Outcomes for Tuberculosis Patients: A Retrospective Cohort Study
Authors: Topçu Yenerçağ Feyza Nur , Aydın Fatih
Published: August 2024

Background: Tuberculosis (TB) is one of the ten leading causes of death globally. The present study aims to examine the treatment outcomes in TB patients and to determine the factors associated with unsuccessful treatment outcomes.
Materials and Methods: This study was a retrospective registry-based cohort study conducted in Ordu pro-vince of Turkey between 2017-2021. Logistic regression analysis was used to explore the risk factors asso-ciated with unsuccessful outcomes.
Results: A total of 400 TB patients were included in the analysis. The observed overall treatment success rate (TSR) (cured or treatment completed) was 87.7% (351). 49 patients (12.3%) had unsuccessful treatment results (death, failure or loss to follow-up). Age>65 years (odds ratio [OR] =12.2, 95% confidence intervals [CI] =4.03-36.85), male gender (OR = 2.2, 95% CI = 1.05-4.45) and being foreign-born (OR = 9.2, 95% CI = 1.16-73.72) were identified as risk factors associated with unsuccessful outcomes in patients (p<0.05).
Conclusions: Age>65 years, male gender and foreign-born patients tend to have unsuccessful treatment outcomes. Careful monitoring of patients with any of these characteristics and taking special precautions for them may help to decrease unsuccessful treatment outcomes.
UPAYA PENGENALAN EDITORIAL DAN PENULISAN JURNAL ILMIAH PADA TENAGA PENDIDIK DI SMP NEGERI 2 KAMPAR KIRI HILIR KABUPATEN KAMPAR
Authors: Fatkhurahman Fatkhurahman , Hadiyati Hadiyati
Published: August 2024

Abstract: Partner situation analysis, teachers become professional educators, especially for those who have received teacher certification. Teachers are required to write scientific articles published in scientific journals so that their work can be read by various groups in need. Partner problems, teachers are still not familiar with scientific editors in the context of publishing scientific manuscripts, there is still a lack of teacher knowledge about how to submit scientific manuscripts to scientific journal editorials to be published in scientific journals. Submitting scientific manuscripts is the first step for teachers in order to publish their scientific work during teaching. So far, teachers still do not understand what scientific journals are and also how to submit scientific manuscripts to editors so that they can be published in scientific journals. The target output to be achieved in this activity is a form of change in the knowledge and ability of teachers as educators to submit scientific manuscripts to editors to be able to publish their scientific manuscripts to scientific journals. The solution provided in this activity is to provide training on submitting scientific manuscripts to editorial to be published in scientific journals. Based on the results of the service that was carried out on December 15, 2016, information was obtained that there was a change in teacher knowledge about what scientific journal publishers are, the usefulness of publishers, submitting manuscripts to publishers and how strategies for writing articles so that they can be published in scientific journals.
PELATIHAN PEMBUATAN PAKAN TERNAK BAGI KELOMPOK TANI DI KABUPATEN MAJENE
Authors: Daud Firdaus , Patongai Dian Dwi Putri Ulan Sari , Arifin Arifah Novia , Pratiwi Andi Citra , Nurinayah Nurinayah
Published: August 2024

Penduduk di Kecamatan Malunda sebagian besar bermata pencaharian sebagai petani sehingga berdampak pada luasnya penggunaan lahan untuk sawah, tegal/kebun, dan ladang. Wilayah yang sangat luas, meningkatnya jumlah penduduk, sarana dan prasarana yang kurang memadai sehingga ketidakterjangkauan pemerintah dalam menjalankan fungsi pelayanan yang maksimal terhadap penduduk, menyebabkan akses informasi menjadi sangat kurang sehingga masyarakat terutama kelompok tani masih kesulitan dalam mengakses teknologi terutama akses teknologi dalam pengolahan pakan ternak. Pelatihan ini dilaksanakan dengan menyajikan materi yang didukung dengan praktik mengenai Hewan ternak dan Pembuatan Pakan, yakni: (1) Konsep Hewan Ternak, pakan ternak (2) Pengetahuan terhadap jenis-jenis pakan ternak serta metode sederhana dalam pembuatan pakan ternak (3) Teknik pengolahan pakan ternak yang meliputi informasi dan praktik langsung mengenai pengolahan pakan ternak yang disesuaikan dengan kebutuhan dan standar kualitas pakan ternak yang baik. Melalui pelatihan ini, mitra akan mempelajari teknik pembuatan pakan ternak yang bertahan hingga 1 bulan dengan daya tahan simpan pada kondisi dan musim yang berubah sehingga dapat tersedia ketika terjadi perubahan musim dan tetap memenuhi kebutuhan masyarakat akan pakan ternak. Hasil dari pelatihan pelaksanaan PKM menunjukkan rerata skor 85,5  hal ini berarti kegiatan pelaksanaan berada pada kriteria baik.Kata kunci: Pakan, Majene, Ternak, Teknologi, Melunda
PENYULUHAN GEMAR MEMBACA UNTUK MENINGKATKAN BUDAYA LITERASI PADA TAMAN PENDIDIKAN AL QURAN (TPA) AL-IKHLAS MUHAMMADIYAH GALESONG UTARA
Authors: Azizah Laelah , Mannahali Misnah , Rijal Syamsu , Taiyeb A. Mushawwir , Angreany Femmy , Alamsyah Alamsyah , Syaputra Arlian Fachrul
Published: August 2024

Literasi merupakan aspek penting dalam kehidupan sehari-hari seseorang. Khususnya iterasi bagi anak-anak merupakan suatu kemampuan yang penting untuk dikembangkan sejak usia dini. Literasi sangat penting bagi anak-anak karena memiliki dampak positif yang luas pada perkembangan mereka dan masa depannya. Kemampuan literasi dasar dapat diperoleh dengan cara membaca, menulis, menyimak, berhitung dan berbicara. Dalam pengabdian ini dikhususkan pada literasi membaca dengan tujuan untuk meningkatkan minat baca anak. Kegiatan yang dilaksanakan seperti pengenalan literasi dan pentingnya literasi, gerakan literasi beruapa membaca cerita bergambar, penyediaan pojok baca sehingga pada saat istirahat, peserta didik dapat mengunjungi pojok baca tersebut. Dengan diadakannya kegiatan ini dapat dijadikan sebagai kegiatan yang membantu menumbuhkan minat baca anak dalam rangka mendukung Gerakan Literasi Bangsa. Literasi merupakan investasi yang sangat berharga dalam masa depan anak-anak. Itu membantu mereka tumbuh menjadi individu yang terdidik, berpengetahuan, dan berdaya saing, serta memiliki peluang lebih besar untuk meraih sukses dalam berbagai aspek kehidupan peserta didik.
PENINGKATAN KOMPETENSI GURU BIOLOGI KABUPATEN GOWA SULAWESI SELATAN PADA MATERI BIOTEKNOLOGI MELALUI PELATIHAN ISOLASI DNA
Authors: Ali Alimuddin , Hiola St. Fatmah , Karim Hilda , Rante Herlina , Yusuf Yusnaeni , Syahdan Ulil Ardi , St. Satiah St. Satiah
Published: August 2024

AbstrakPengajaran Bioteknologi modern pada Kurikulum di sekolah menengah atas menuntut kompetensi guru dalam memvisualisasi DNA sebagai materi genetik. Untuk itu diperlukan keterampilan dan peralatan yang memudahkan siswa mengamati materi genetik melalui proses isolasi DNA. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kompetensi guru-guru melalui pelatihan isolasi DNA. Peserta kegiatan ini adalah guru SMA, MA dan MTs dalam wilayah Kabupaten Gowa, Sulawesi Selatan. Tahapan kegiatan antara lain pemaparan teori, peragaan, latihan isolasi DNA, diskusi dan tanya jawab. Hasil kegiatan pengabdian ini menunjukkan bahwa para peserta pelatihan mampu meningkatkan pemahaman terkait dengan konsep atau teori DNA. Selain itu peserta terampil melakukan praktek isolasi DNA menggunakan bahan dan peralatan sederhana dengan biaya murah. Melalui pelatihan ini, diharapkan keterampilan dan pengalaman guru dapat diimplementasikan dalam proses belajar mengajar di sekolah. Kegiatan ini diharapkan berdampak pada upaya meningkatkan minat siswa belajar Bioteknologi serta kecakapan guru terkait cara mengisolasi DNA makhluk hidup.Kata kunci: Bioteknologi, isolasi DNA, guru Biologi, kithcen kiAbstractTeaching modern biotechnology in the high school curriculum requires teacher competence in visualizing DNA as genetic material. This requires skills and equipment that make it easier for students to observe genetic material through the DNA isolation process. This community service activity aims to improve the competence of teachers through DNA isolation training. Participants in this activity are SMA, MA and MTs teachers in the Gowa Regency area, South Sulawesi. The activity stages include theoretical presentations, demonstrations, DNA isolation exercises, discussions and questions and answers. The results of this service activity show that the training participants were able to increase their understanding of DNA concepts or theories. Apart from that, participants are skilled at practicing DNA isolation using simple materials and equipment at low cost. Through this training, it is hoped that teachers' skills and experience can be implemented in the teaching and learning process in schools. This activity is expected to have an impact on efforts to increase students' interest in learning Biotechnology as well as teachers' skills regarding how to isolate the DNA of living things.Key words: Biotechnology, DNA isolation, Biology teacher, kithcen ki,
PENGEMBANGAN PENGETAHUAN MASYARAKAT DESA PUNAGA KABUPATEN TAKALAR DALAM PENGELOLAAN LIMBAH ORGANIK DAPUR MELALUI KEGIATAN PELATIHAN PEMBUATAN ECO ENZYME
Authors: Ramadani Muh. Fajar , Salsabila Shopia , M Ratna , Iskandar Azizah Syahrani , Hajirah Rizkyllah Nur , Azani Syahrul Akbar , Putri Nurul Edyawati , Junda Muhammad
Published: August 2024

Punaga Village, Laikang District, Takalar Regency, is a village where the majority of residents are farmers and planters. Organic kitchen waste is a serious problem faced by many local communities, besides producing unpleasant odors, it can also disturb the beauty of the environment. This problem continues to exist due to the local community's lack of knowledge or skills in managing organic kitchen waste. So a service activity was carried out, namely training in making Eco enzyme. This training aims to increase public knowledge about the management of kitchen organic waste. Eco enzyme solution is the result of fermentation of leftover fruit and vegetables mixed with water and brown sugar. The method used in service consists of several stages including: (1) Observation and Interview, (2) Preparation Stage, (3) Implementation Stage. This activity is carried out by providing training and assistance directly to the community. This training was attended by 28 participants from several groups, including the village government, youth organizations, and the Punaga village community. In this training, participants were taught how to make Eco enzyme, starting from the ingredient preparation stage, making the mixture to the fermentation stage. The training participants were very enthusiastic about taking part in the training, the participants thought that this training was useful for them, because it could increase people's insight into managing waste. The result of this service is an increase in the community's potential in making Eco enzymes. Among the 28 participants who attended, there were 22 people who were categorized as being able to understand the material provided well. The next implication of this activity is that it can be used as a profit activity by selling products that have been made, so that this activity is sustainable.
PELATIHAN TEKNIK HIDROPONIK MELON BAGI KELOMPOK GURU DI KABUPATEN MAJENE
Authors: Daud Firdaus , Taiyeb A. Mushawwir , Pratiwi Andi Citra , Azis Andi Asmawati , Jamaluddin Asham Bin , Marzuki Nur Intan , Mukminati Sri
Published: August 2024

Cultivating plants using hydroponic methods promises better plant quality compared to conventional methods. However, the application of this technique is still relatively low among the public, especially in Majene Regency, West Sulawesi Province. Meanwhile, the potential for cultivating plants using hydroponic methods in Majene Regency is significant due to the availability of vast land and supportive environmental conditions. Therefore, this community service activity is conducted to increase public knowledge about hydroponic plant cultivation methods in Majene Regency. The training was held on May 11, 2024, at SMPN 2 Majene, and attended by 25 teachers from various districts in Majene Regency. They were selected based on their communication skills and potential to implement the training to students and the surrounding community. The training utilized lecture, discussion, and hands-on practice methods. Participants' response to the training was highly positive, with the majority feeling assisted by the training activities. Subsequent activities are recommended to integrate more innovative hydroponic techniques. It is hoped that the increase in knowledge and skills will encourage more people to adopt hydroponic methods, thus improving the income of the West Sulawesi community.
DETECTION OF BLACK HEART DISEASE IN SEED POTATO BASED ON TRANSMISSION SPECTROSCOPY TECHNIQUE
Authors: WANG Xianhe , HAO Min , CAO Xingtai , ZHANG Yutao
Published: August 2024

Black heart disease is one of the screening indicators of seed potatoes, which has a serious impact on the quality and yield of potato, and at present there are fewer non-destructive testing methods for internal defects of seed potatoes. This paper aims to utilize non-destructive testing technology to quickly identify qualified and black hearted seed potatoes, and then to protect yield and food security. In this paper, transmission spectroscopy system was utilized to collect the spectral data of 104 qualified seed potatoes and 104 black hearted seed potatoes in 450~940 nm band. Subsequently, four algorithms, namely Savitzky-Golay (SG), Standard Normal Variate (SNV), Multiplicative Scatter Correction (MSC) and First-order Derivative (FD), were utilized to pre-process the seed potatoes spectral data to improve the data noise ratio. Feature wavelength extraction was made using Competitive Adaptive Reweighted Sampling (CARS) and Successive Projections Algorithm (SPA) to enhance the sample data characteristics and improve the model interpretability. The construction of classification models for qualified and black hearted seed potatoes relied on two deep learning techniques, Convolutional Neural Networks (CNN) and Recurrent Neural Network (RNN), which were trained and tested for the feature bands respectively. The experimental results showed that SG-CARS-CNN was the optimal combination of classification algorithms, and the classification accuracies of both the training set and the test set reached 100%, which improved the accuracy of the test set by 3.85% compared with that of the traditional machine learning algorithms, and provided an accurate method for the rapid screening of qualified seed potatoes.