bluuebunny/crossref_metadata_2025 huggingface dataset:
Antihyperlipidemic activity of petroselinum crispum seeds in high fat diet induced atherosclerosis in experimental animals
Authors: Rathi Shikha , Jalwal Pawan , Kharb Manju
Published: June 2022

Atherosclerosis is one of the major contributing factors for the mortality due to cardiovascular diseases. Although a number of therapeutic agents are available still the management of atherosclerosis is not completely possible due to associated side effects with these therapeutic agents. Due to this herbal drug are considered as alternative for the treatment of atherosclerosis. Among these herbal drugs, Petroselinum crispum seeds are considered as potential agent for the treatment of atherosclerosis. In the present study, hydroalcoholic extract and petroleum ether extract of P. crispum seeds was prepared and anti-atherosclerotic activity was evaluated in High fat diet induced atherosclerosis in rats. Qualitative and quantitative analysis of hydroalcoholic extract was carried and in vitro and in vivo antioxidant activity was evaluated. Antiatherosclerotic activity was evaluated by measuring serum cholesterol, serum triglycerides, serum low-density lipoprotein (LDL), very low-density lipoprotein (LDL) and high-density lipoprotein (HDL) level in animals. Animals were kept on high fat diet for 45 days and different doses of hydroalcoholic and petroleum ether extract were administered. Administration of different doses significantly attenuated the elevated level of serum cholesterol, serum triglycerides, serum LDL, VLDL and elevated HDL level. Oxidative stress was also found to be significantly attenuated in in vitro and in vivo models. From the study it can be concluded that hydroalcoholic and petroleum ether extract of P. crispum seeds significantly attenuated elevated oxidative stress and lipid profile.
32 Factorial Design Screened Abelmoschus esculentus Fruit Mucilage abetted Floating Microspheres of Clarithromycin for Exterminating Helicobacter pylori
Authors: Ampapuram Rajesh Pavan , S. Rajendran Ramakrishnan , Subramaniyan Gopinath
Published: June 2022

The study aims to investigate the floating possessions of Abelmoschus esculentus fruit mucilage by incorporating it into floating microspheres with Clarithromycin. Nine interpretations of floating microspheres were made with sodium alginate (SA) and varying proportions of A. esculentus fruit mucilage (AEFM). A central composite design with design expert software to check the impact of independent variables (AEFM and SA levels) on entrapment efficacy and floating time (FT). As part of congeniality studies, the microspheres were scrutinized for clarithromycin (CMN) content and its release. The research discovered that CMN entrapment increased with an increase in AEFM levels in the formulations and that the FT was greater in formulations with higher AEFM levels. In formulations containing higher levels of AEFM, the drug release is slightly reduced. The study revealed that Clarithromycin is capable of good stomach-specific drug delivery by formulating it with SA as floating microspheres and the assets were enhanced by AEFM.
Lipid Based Solid Self-Emulsifying Delivery System of Pitavastatin Calcium: Development and Characterization
Authors: P. Patil Moreshwar , Chavan Devyani P. , Bhutada Rohan R. , Murkunde Vardhman A. , Kshirsagar Sanjay J.
Published: June 2022

Solid self-emulsifying delivery system containing pitavastatin calcium was developed using oil and hydrophilic surfactants. Pitavastatin calcium has low solubility and low bioavailability; hence, it was meaningful to improve solubility and dissolution properties by using suitable formulation component and process. Based on preliminary study, oleic acid, Tween 20 and PEG 400 were utilized for development of self-emulsifying system. Microemulsion region was identified by pseudo-ternary phase diagrams. The liquid system: adsorbent (Aerosil 200) at a ratio of 2:1 was employed for spray drying. The system was evaluated for emulsification time, percent drug content, in-vitro dissolution. The other analytical techniques used for characterization were fourier transform infrared spectroscopy (FTIR), DSC, standard error of the mean (SEM), particle size, zeta potential and XRD. The optimized formulation had particle size of 172.2 nm and the drug content found was 96.38%. It also had shown 95.98% drug release at the end of 1 hr which was more when compared to pure drug. It was observed that increase in surfactant concentration decreases dispersion time and particle size with concomitant increase in amount of drug released. The XRD diffractogram confirmed the conversion of drug from crystalline to amorphous form. The spray dried particles had smoother surface. The DSC thermogram showed no melting endotherm in the system indicating well dispersed drug with amorphous nature.
Design and Characterization of Punica granutum Seed Oil-loaded Cream: Assessment of In vitro Antimicrobial Potential
Authors: Phatak Atul , Ghurghure Shrishail
Published: June 2022

The present investigation was started with aim to formulate and assess the antimicrobial potential of Punica granatum seed oil cream. The P. granatum seed oil cream was formulated using glyceryl monostearate and other lipids like stearic acid as well as cetyl alcohol. The formulated cream was then evaluated with respect to physicochemical properties and in vitro antimicrobial activity against Escherichia coli. The formulated oil loaded cream showed acceptable physicochemical properties like pH, spreadability, type of emulsion and viscosity which confer its suitability for topical application. In addition to this, the in vitro antimicrobial potential of oil loaded cream against E. coli was also found to be acceptable. Thus, formulated cream could be promising alternative for topical application of P. granatum seed oil with better antimicrobial potential.
Phytochemical Studies of Tephrosia purpurea Linn. and Martynia annua Linn. extracts for Identification of Chemical Constituents
Authors: Singh Rakesh , Kori Mohan Lal
Published: June 2022

Present study was aimed to study phytochemical study for qualitative screening of Martynia annua Linn. and Tephrosia purpurea Linn. for chemical constituents. Extraction of aerial parts of T. purpurea and M. annua leaves was performed by using ethyl alcohol, ethyl acetate, chloroform and petroleum ether. Flavonoid rich extracts of M. annua and T. purpurea was obtained from ethyl alcohol extract. Selected flavonoid rich fraction of both plant was further assess by thin layer chromatography for the pattern of chemical constituents. After development of solvent system both fractions was used for high performance thin layer chromatography (HPTLC). Results were confirmed that percent yield of fractions were calculated as 56.1%w/w (TP-A) and 4.2%w/w (MA-C). Both fraction was confirmed the presence of quercetin. In conclusion both plants and T. purpurea and M. annua extract contains quercetin as 66.35 mg and 28.42 mg, respectively determined by HPTLC method. These two plants are rich source of flavonoids that may be useful for treatment of various diseases.
Evaluation of the safety and efficacy of T-AYU-HM Premium and Onion steam inhalation in mild to moderate Covid-19 Patients
Authors: Desai Atul , Desai Kavita , Desai Hemshree , Desai Chirag , Desai Rutvij
Published: June 2022

Coronavirus disease (COVID-19) has impacted many nations' health care and their economic growth within no time. This Pandemic situation demands a safe and cost-effective treatment as early as possible to prevent any further suffering. To clinically evaluate the safety and efficacy of T-AYU-HM Premium Tablets (600 mg) and onion steam inhalation in mild to moderate COVID-19 patients. The trial is an open-label, Single-arm study conducted in mild to moderate level coronavirus patients. 30 participants infected by the coronavirus enrolled for the study, on providing informed consent. AYUSH standard mark anti-sickling tablet T-AYU-HM Premium 600mg twice a day and onion steam inhalation once every morning once for 21 days was prescribed to the patients along with strict home quarantine instructions. Both clinical and pathological changes recorded on the baseline, 5th, and 21st day of the trial. Any adverse events reported by the patients and those observed by the principal investigator recorded. All the patients recovered clinically, and no untoward effects observed during this trial period. A significant reduction (p < 0.05) observed in the pathological parameters like C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and lactate dehydrogenase (LDH). The oxygen saturation (SpO2) level sustained within normal limits during the treatment period suggesting that further complications and hospitalization evaded. The impact of the treatment regimen T-AYU-HM Premium and onion steam inhalation on clinical and pathological parameters suggest that it is safe and indicate its potential candidacy in the treatment of COVID-19.
Design and Characterization of Paclitaxel Loaded Nanoparticles with Piperine
Authors: SAHU GYANESH K. , SHARMA HARISH , PAUL SWARNALI DAS , AJAZUDDIN  , Kaur Chanchal Deep
Published: June 2022

Paclitaxel is a cytotoxic drug having wonderful mechanism against cancer cells. However, it showed severe dose-limiting toxicity when administered as infusion. To overcome these side effects a suitable delivery system is highly desirable. Bioenhancers, when mixed with drugs promote and augment their bioavailability and reduced incidence of drug resistance and risk of adverse drug reaction. Therefore, based on the literature survey nanoparticles are selected as a delivery system in this study. The object of this work was to entrap paclitaxel and herbal bioenhancer in a nanoparticle system. In that work the nanoparticles prepared the by emulsion solvent evaporation method with Eudragit RLPO1 polymer. The prepared nanoparticles were evaluated for particle size, zeta potential, drug entrapment, in vitro drug release. Further the nanoparticles were evaluated for in vitro cell cytotoxicity study by mean transit time (MTT) assay on lung cancer cell line and pharmacokinetic profile. The bioenhancer loaded nanoparticles show betrer in-vitro properties with 124 to 200 nm particle size range. All the formulations released within the range of 82.71 to 95.47% of drug in 24 hours. The release kinetic of drug was best fitted to Higuchi’s model and was following Fick’s law of diffusion. All the nanoparticle batches had good drug entrapment capacity in the range of 57.51 to 86.12%. The pure drug solution could not inhibit the cell proliferation completely but the nanoparticle formulations significantly reduced the cell proliferation in MTT assay. Surprisingly, formulation with higher bioenhancer loading (FNP 6) showed a higher antiproliferative effect on A549 cells. In in vivo pharmacokinetic assay, the plasma level of FNP-6 was highest than other formulation including control. The AUC of FNP-6 was 6.423 μg/mL and the absolute bioavailability of FNP-6 was 7.89. FNP-5 and FNP-6 had a higher bioenhancer quantity as compare to the other formulation this may be possible reason of their higher absolute bioavailability. Therefore, it can be concluded that addition of bioenhancer with antitumor drug can enhance its proliferative effect and bioavailability.
Comparative study of herbal bioenhancer containing nano formulation for oral delivery of paclitaxel: pharmacokinetic and cytotoxicity analysis
Authors: SAHU GYANESH KUMAR , SHARMA HARISH , AJAZUDDIN  , Kaur Chanchal Deep
Published: June 2022

The main objective of this study was to develop novel formulation containing herbal bioenhancer to increase the bioavailability of poorly water-soluble anticancer drug. Paclitaxel (PTX) loaded bioenhancer (Piperine and Quercetin) nanoparticle prepared by emulsification solvent evaporation method by using Eudragit RLPO as a polymer and to evaluate its in-vivo pharmacokinetics (PK) and cytotoxicity studies. The result is reduced oral bioavailability, which limits the use of paclitaxel, a crucial anticancer medication, when taken orally. Though multiple formulation approaches have been taken to fight this low absorption profile but consequence of different herbal bioenhancer, happening CYP3A and P-gp inhibitor on augmentation of bo plasma. Paclitaxel loaded nanoparticles with both bioenhancer used for this study and pharmacokinetic, cytotoxic study (MTT Assay) was used for comparative study. The prepared nanoparticles were evaluated for in vitro cell cytotoxicity study by MTT assay on lung cancer cell line and pharmacokinetic profile. The result revealed good in vitro properties with bioenhancer.  The goal of the present work is to asses any modification in oral pharmacokinetics of paclitaxel. Therefore, it can be concluded that addition of bioenhancer with antitumor drug can enhance its prolifertive effect. However, further in vivo studies are recommended to establish the fact.
Possible Reversal of Carbon Tetra Chloride-induced Liver Fibrosis in Sprague Dawley Rats treated with Stromal Vascular Fraction and Activated Platelet Rich Plasma
Authors: Sharma Anuka , Sharma Vijay , Ghorpade Parag Rambhau , Nandanwar Manohar , Kansagara Atul , Tripathi Sandeep
Published: June 2022

Stromal vascular fraction (SVF) is considered a promising source of stem cells, but potential of treatment of damaged liver has not been fully explored. Aim: In this study, we sought to evaluate the hepato-regenerative effect of SVF combined with activated platelet rich plasma (aPRP) on carbon tetrachloride (CCl4) induced hepatic injury in Sprague Dawley (SD) rats. Liver fibrosis was induced using CCl4 in 30 SD rats. Sixteen rats survived and were divided into two groups – control and treated. SVF and aPRP were prepared by standard methods from three normal donor rats. Combination SVF-aPRP was administered intravenously via the lateral tail vein in treated group animals, on Day 0, 7 and 14. Normal saline of same dose volume was administered to the control group. AST and ALT levels were monitored throughout the study duration of 28 days. Gross and histopathological analysis of liver was performed post sacrifice on Day 28. Decrease in the ALT/AST levels over the duration of study was observed in both control and treated groups, with a statistically significant reduction in AST/ALT levels between Control ad Treated groups on Day 28. Gross morphological evaluation, fibrosis and cirrhosis grades also showed reduction between control and treated groups. Observations of enzyme levels, gross and histopathological analyses revealed a reduction in severity of liver fibrosis in the treated group. However, we have identified additional parameters that need to be evaluated to corroborate these research findings.
Effect of Nutraceutical Formulation Ovajal on DHT and Fructose-induced Polycystic Ovary Syndrome in a Rodent Model
Authors: KUMAR G. SANTHANA , Tirgar Pravin R. , Rachh Punit R.
Published: June 2022

Polycystic ovary syndrome is a most common female reproductive disorder, involving endocrine and metabolic disorders with unclear etiology. It may clinically be manifested in young women of reproductive age as oligo-ovulation, abnormal levels of reproductive hormones, clinical hyperandrogenism, hirsutism, male pattern baldness, acne, acanthosis nigricans, and polycystic ovaries, additionally having a long prodroma with detectable abnormalities that present as the metabolic syndrome like Insulin resistance, hyperinsulinemia, obesity, and dyslipidemia. Current treatment options are unable to manage PCOS and suffer from unwanted effects. The present study aimed to investigate the effect of nutraceutical formulation ovajal on dihydrotestosterone (DHT)-fructose-induced polycystic ovary syndrome (PCOS) in Sprague Dawley (S.D.) female rats. Prepubertal rats in the experimental group (except control) received coadministration of DHT (s.c.) and fructose(p.o.). Along with DHT+F other groups were treated with OV100 & OV200, clomiphene, and metformin, at a dose of 100 mg/kg p.o., 200 mg/kg p.o., 100 mg/kg p.o., & 200 mg/kg p.o., respectively for 90 days. Estrus cyclicity, OGTT, luteinizing hormone, follicle-stimulating hormone, insulin, testosterone, and estradiol serum levels were assessed. Ovary, uterus, abdominal fat, and subcutaneous fat were collected, weighed and an ovary histomorphology examination was done. Results showed that OV100 and OV200 reversed the DHT-fructose induced changes by significantly (p < 0.05) increasing serum FSH level, estradiol level and decreasing their body weight, ovary weight, uterine weight, serum luteinizing hormone level, testosterone level, oral glucose tolerance, irregular estrous cyclicity and no. of cystic follicles. However, the OV200 notably ameliorated the abnormalities of experimental PCOS. Our study findings demonstrate that ovajal formulation exerted preventive benefits in an experimental model of PCOS. Hence can be suggested in the management of PCOS.
Fabrication of Mebendazole Loaded Solid Lipid Nanoparticles: Formulation, Optimization, Characterization, Stabilization, and In-Vitro Evaluation
Authors: Shrivastava Saurabh , Kaur Chanchal Deep
Published: June 2022

The research focused on the formulation, optimization, characterization stabilization and in vitro evaluation of Mebendazole loaded solid lipid nanoparticles (MEB-SLN) using response surface methodology. MEB-SLN was developed using the melt-emulsification ultrasonication method. The optimized formulation contains Compritol 888 ATO as a solid lipid and Poloxamer 407 as a surfactant. The optimized MEB-SLN was spherical, and had an average size of 230.4nm, and zeta potential of -21.9mV. The physiochemical characterization included the evaluation of surface morphology, drug entrapment, x-ray diffraction studies, and differential scanning calorimetry. In vitro drug release studies revealed that MEB-SLN would release drugs for up to 24 hrs. The formulation was found to be significantly quite stable in the refrigerator than at room temperature, as per stability tests. As a result of these findings, MEB-SLN was identified as a possible drug carrier. This provides a framework for further exploration of the developed formulation.
NEUROLOGICAL COMPLICATIONS IN COVID PATIENTS
Authors: Askarkar Sonali , Dhande Anushka , Gosavi Mayuri
Published: June 2022

COVID-19 has a very cataclysmic impact on the world's panoramic view of human well being in terms of healthcare and management. The COVID-19 Infection with an increasing number of patients has not only affected the physical but also the mental state of society. The symptoms manifested by COVID-19 range from fever, malaise, myalgia, headache, to respiratory system symptoms of cough, stuffy/runny nose, and difficulty breathing. The novel coronavirus is known to affect the central nervous system, producing critical and some long-lasting neurological concerns. It has an impact on the pre-existing mental and affective ill patients as well as healthy individuals with anxiety, worrying, and panic symptoms, and fear conditioning, which has become a big concern. Although COVID-19 is a respiratory infection and the cardiovascular event is the main cause of fatality, medical professionals must understand its neurological complications to reduce the mortality rate in infected patients. Further research on specific risk factors or determinant protective factors from the neurological symptoms is needed to reduce the risk of complication in COVID-19 infection cases. This review highlights the possible pathogenesis and mechanisms of invasions with the associated Neurological impacts like GBS, encephalitis and meningitis based on various case reports and research articles to date.
Understanding triple negative breast cancer: A review on molecular signaling pathways
Authors: Patel Pankti J. , Shah Jigna S.
Published: June 2022

Triple negative breast cancer (TNBC) is a divergent disease which lacks receptor for estrogen (ER), progesterone (PR) and human epidermal growth factor receptor 2 (HER2). It constitutes about 15-20% of total breast cancer cases globally which mainly strikes younger women. Due to its aggressive nature, the standard choice of treatment for TNBC is chemotherapy, but the same has very poor prognosis due to risk of tumor recurrence, metastasis and death. To direct the line of research to get pathological Complete Response (pCR) and increase the quality of life (QOL) years of cancer patients, it is necessary to understand the molecular pathways and their down signalling pathways which can be targeted. Triple negative breast cancer involves several signaling pathways leading to tumor initiation, proliferation, and metastasis such as Ras/Raf/MEK pathway, PI3/AKT/mTOR pathway, DNA repair pathway, Wnt/β-catenin Pathway, Hedgehog pathway, Notch signalling pathway and immune pathway. Currently available treatment for triple negative breast cancer comprises chemotherapy in combination which includes anthracyclines, platinum compounds, folate antagonist, taxanes, cyclophosphamide and others. The present review focuses on the molecular aspect of TNBC subtypes and targets. Also, the ongoing clinical trials along with the completed clinical trials targeting different pathways for the treatment of TNBC patients are discussed.
Ukrainan kirjastot sodassa: vastarintaa ja aktiivista toimijuutta
Authors: Lauhakari Ari-Pekka , Kiviluoto Johanna
Published: June 2022

Venäjä hyökkäsi Ukrainaan 24.2.2022. Siitä lähtien mediaa on hallinnut kuvasto pommitetuista kaupungeista ja sotaa pakenevista siviileistä. Mutta minkälainen on Ukrainan kirjastojen tilanne sodan keskellä? Tässä lyhyessä katsauksessa kerrotaan kirjastomaailman reaktioita Ukrainan tilanteeseen, ja toisaalta kerrotaan muutamin esimerkein, miten kirjastot Ukrainassa ovat sotaan reagoineet.
Palvelumuotoilulla parempaa datatukea
Authors: Karhapää Anne , Nurmi Niina , Satama Manna
Published: June 2022

Datanhallinta on vielä uusi asia tutkimuksen arjessa, ja siihen liittyvät tukipalvelut ovat monessa organisaatiossa vasta muotoutumassa. Itä-Suomen yliopistossa datatuen palveluiden kehittämiseen avuksi otettiin palvelumuotoilun menetelmät. Palvelumuotoilu on yhteiskehittämistä hyödyntävä prosessi, joka lähtee käyttäjien tarpeista. Persoonien ja palvelupolkujen kautta saatiin vahva käyttäjäymmärrys, jonka avulla luotiin Itä-Suomen yliopiston datatuen palvelukonsepti.
PEMBERIAN RATIONAL-EMOTIVE BEHAVIOR THERAPY DAN ASSERTIVE TRAINING SEBAGAI UPAYA MENGURANGI PERILAKU AGRESIF PADA REMAJA DI PAUH PADANG
Authors: Sarfika Rika , Afriyeni Nelia , Hermalinda Hermalinda , Feri Fernandes Feri Fernandes
Published: June 2022

Perilaku agresif remaja di Kota Padang sudah sangat meresahkan dan bahkan sudah mengarah pada tindakan kriminal. Perilaku agresif ini dapat merugikan remaja itu sendiri, keluarga dan lingkungan disekitar mereka. Tujuan kegiatan ini adalah untuk mengurangi perilaku agresif melalui pemberian Rational Emotive-Behavior Therapy (REBT) dan Assertive Training (AT). Peserta kegiatan ini adalah remaja siswa di SMA Negeri 15 Padang dan SMA Negeri 9 Padang. Sebanyak 36 siswa dari 2 sekolah ini diberikan terapi secara berkelompok berdasarkan asal sekolah masing-masing. Kriteria peserta kegiatan adalah siswa dengan perilaku agresif dan bersedia mengikuti terapi REBT dan AT selama 2 minggu. Sebelum dan sesudah pemberian terapi, remaja diberikan kuisioner Agression Questionaire (AQ) untuk mengukur perilaku agresif yang dimiliki remaja. Data dianalisis menggunakan uji t-berpasangan (paired t-test). Hasil analisis data menunjukkan bahwa ada perubahan signifikan dalam perilaku agresif remaja sebelum dan sesudah diberikan REBT-AT. Perubahan signifikan terjadi pada perilaku agresi fisik dan permusuhan. Namun, pada agresi verbal dan kemarahan tidak ada perubahan yang signifikan. Berdasarkan hasil kegiatan, pemberian REBT-AT belum mampu mengurangi semua komponen perilaku agresif yang dimiliki remaja. Idealnya, untuk mendapatkan hasil yang maksimal, terapi harus diberikan selama 4 minggu untuk REBT dan 4 minggu untuk AT. Untuk itu, perlu evaluasi lebih lanjut selama 8 minggu untuk mengetahui apakah program ini berhasil dalam mengatasi perilaku agresif pada kelompok terapeutik ini.
PENERAPAN EKONOMI DIGITAL PEREMPUAN PENGRAJIN BORDIR DALAM RANGKA PENGUATAN EKONOMI RUMAH TANGGA DI NAGARI SINGGALANG TANAH DATAR
Authors: Andriani Yessy , Dewi Laksmi , Indrawari Indrawari
Published: June 2022

The embroidery craftsmen in Nagari Singgalang, Tanah Datar, have exquisite quality embroidery, but they do not significantly impact the craftsmen's income. This is because most of them are only wage earners. The wages they receive are not proportional to the processing they do. However, they do not have the bargaining power to increase wages due to many embroidery artisans. Low levels of education, lack of capital, and lack of knowledge about embroidery marketing are obstacles for them to develop. This activity aims to increase the productivity of artisans to become independent craftsmen (producers). The methods used are public participation and women participation in the economy through counseling, socialization, digital marketing training, and embroidery craftsmen. The extension is carried out to motivate them to be more productive while the practice is focused on digital marketing training to promote and market their products. The formation of an embroidery group is done so that they can work together and move forward together. This service is also complemented by providing embroidery materials and equipment to the assisted embroidery groups to start production and marketing themselves and not only as wage earners. The results of the activity resulted in four mukenah pieces with different variations and prices. The resulting product has been sold well so that the proceeds from the sale are used again to buy production materials, and part of it is distributed as profit. Thus this activity has a positive impact on the development of the embroidery business in Nagari Singgalang. In the future, this activity can become a pilot project for other groups to improve the embroidery craftsman family's welfare.
PENGEMBANGAN RUMPUT GAJAH SEBAGAI PAKAN SAPI DI OPHIR NAGARI KOTO BARU KABUPATEN PASAMAN BARAT
Authors: Syaiful Ferry Lismanto , Utami Yayuk Sri
Published: June 2022

The Opir area is located in Nagari Koto Baru, Luhak Nan Duo District, West Pasaman Regency. This area has a large area of land that has great potential in developing beef cattle. Increasing the beef cattle population really requires the availability of quality and sustainable feed. Elephant grass is one type of forage / superior grass with a high nutritional content used as cow feed. The development of elephant grass is to provide good quality forage. Elephant grass has a lot of biomass production, can be harvested several times a year; even this forage is easy to cultivate. The purpose of the activity is to provide education and proper and correct elephant grass cultivation techniques, land optimization, and improve the quality of forage as beef feed. This training activity was held in Jorong Ophir, Nagari Koto Baru, West Pasaman Regency. The activity methods used are socialization, counseling, demonstration, and evaluation. The targets of this activity are farmers and communities in Ophir, Nagari Koto Baru. The results of the activity showed that the participants as the target of the activity were very enthusiastic and gave good responses. Extension of elephant grass cultivation started from land preparation, planting, maintenance and harvesting. In this activity, farmers increase their knowledge and skills in determining good elephant grass seeds and proper and correct elephant grass cultivation techniques. It is hoped that this activity can be carried out sustainably by breeders to optimize land and availability of good quality and sustainable forage as animal feed to increase livestock productivity.
LITERASI VISUAL MEDIA EDUKASI POSTER TERKAIT COVID-19 PADA SISWA SMA DI KOTA PADANG
Authors: Wahyuni Ullya Mega , Rahmadoni Jefril , Kartika Afriyanti Dwi , Arifnur Adi Arga , Kamil Husnil , Silvana Meza , Akbar Ricky , Wahyudi Wahyudi
Published: June 2022

Secara resmi Organisasi Kesehatan Dunia (WHO) menetapkan bahwa COVID-19 sebagai pandemi dan pemerintah Indonesia juga menetapkan bahwa wabah Corona sebagai bencana Nasional. Untuk bisa melaksanakan berbagai aktivitas di masa pandemi, maka perlu dilakukan Komunikasi, Informasi, dan Edukasi (KIE) kepada masyarakat terkait COVID-19. KIE dapat dilakukan dengan memanfaatkan poster sebagai media komunikasi. Kegiatan ini ditujukan kepada siswa/I SMA yang ada di kota Padang. Tujuan dari kegiatan ini adalah memberikan pelatihan kepada siswa/i SMA yang ada di kota Padang, agar bekal ilmu yang diberikan dapat dimanfaatkan dengan membuat poster edukasi dan menyebarkan informasi terkait COVID-19 kepada masyarakat melalui media sosial sebagai bentuk kepedulian para siswa/i untuk mengurangi penyebaran Virus Corona. Kegiatan ini melibatkan siswa/i dari empat sekolah yang ada di kota Padang yaitu SMAN 7, SMAN 11, SMA Pertiwi 2 dan SMA Don Bosco Padang. Metode pelaksanaan pada kegiatan Pengabdian Kepada Masyarakat ini terdiri dari tiga tahap yaitu persiapan, implementasi, dan evaluasi. Selama kegiatan berlangsung, peserta sangat antusias mengikuti kegiatan sampai tahap akhir. Ketercapaian target dari kegiatan ini adalah 90% dilihat dari peserta yang mengumpulkan hasil poster edukasi selama pelatihan. Sedangkan kemampuan literasi visual peserta sebesar 85%, dinilai dari pemahaman dan pemaknaan pesan visual yang dituangkan ke dalam poster edukasi. Untuk meningkatkan antusias dan semangat kepada peserta agar tetap semangat berkarya secara daring di masa pandemi, maka diadakan pemilihan best poster dari peserta yang ikut kegiatan pengabdian kepada masyarakat.
PENGUATAN KELEMBAGAAN PETANI BARAMBAN DALAM PEMASARAN SAYUR SEHAT BERSERTIFIKAT PRIMA 3 DI KECAMATAN BANUHAMPU KABUPATEN AGAM, SUMATERA BARAT
Authors: Noer Melinda , Herviyanti Herviyanti , Habazar Trimurti , Refdi Cesar Welya
Published: June 2022

Kelompok Tani Baramban sejak tahun 2014 telah melaksanakan usaha tani sayuran sehat dengan produk sayur yang telah bersertifikat Prima 3. Namun sampai saat ini, pengelolaan usaha tani sayuran sehat oleh Kelompok Tani Baramban di Kecamatan Banuhampu, Kabupaten Agam ini belum banyak mengalami perkembangan usaha tani karena belum terciptanya pasar yang luas dengan harga yang memihak kepada kesejahteraan petani. Penguatan kelembagaan petani dalam pemasaran sayuran sehat dengan demikian menjadi sangat penting dan menjadi elemen penting dalam pengembangan agribisnis sayuran sehat, baik di pasar lokal, nasional, bahkan pasar global. Metode yang digunakan adalah penyuluhan, pembinaan dan pendampingan. Kegiatan ini direncanakan akan dilaksanakan selama lima tahun ke depan, yang dimulai dengan membangun kesepakatan kerjasama dengan kelompok tani Baramban, dimulai tahun 2020. Beberapa alternatif solusi untuk menyelesaikan permasalahan mitra kelompok usaha tani sayuran sehat yang diusulkan dan disepakati oleh Kelompok Tani Baramban adalah sebagai berikut: a. Melakukan kegiatan pendampingan kepada petani sayuran sehat dengan mentransfer daya dari perguruan tinggi melalui keilmuan yang terintegrasi dengan cara pandang agribisnis, b. Pemberdayaan petani dengan basis Penguatan Kelembagaan kelompok agar terbangun aksi kolektif (collective action) yang kemandirian petani untuk menggerakkan pasar sayuran sehat, c. Memfasilitasi petani untuk menciptakan segmen pasar sayuran sehat, melalui pasar modern dan pasar online (online market) dengan teknologi informasi 4.0 dan 4. Membangun kemitraan dengan Transmart sebagai pasar modern berskala nasional dan memiliki jaringan pemasaran berskala global. Kesimpulan adalah bahwa kelompok tani bersedia untuk menjadi partner Tim Pengabdi dalam skim program kemitraan masyarakat membantu usaha berkembang.
PENGEMBANGAN ITIK PITALAH BERBASIS PROBIOTIK DAN PENGOLAHAN POSTHARVEST DI KECAMATAN BATIPUH KABUPATEN TANAH DATAR
Authors: Husmaini Husmaini , Arlina Firda
Published: June 2022

Itik Pitalah merupakan plasma nutfah Sumatera Barat telah ditetapkan rumpunnya melalui Kepmen No. 293/kpts/OT.140/6/2011. Konsekuensi penetapan tersebut dipandang penting menjaga populasi dan kemurnian Itik Pitalah melalui aktivitas seleksi tetua dan budidaya Itik Pitalah di Kecamatan Batipuh sebagai daerah insitu Itik Pitalah. Tujuan kegiatan ini adalah pengembangan, budidaya dan pengolahan pasca panen Itik Pitalah untuk meningkatkan pendapatan masyarakat. Metode yang digunakan meliputi pembekalan mahasiswa, sosialisasi kegiatan dan perancangan rencana kerja dan lokakarya rencana kegiatan. Kegiatan ini melibatkan 30 mahasiswa Unand. Hasil Pelaksanaan kegiatan yaitu menetaskan telur yang dihasilkan dari induk produktif dari flock yang dibuat berdasarkan ciri-ciri Itik Pitalah, hasil penetasan dibudidayakan secara intensif agar mortalitas lebih rendah dan pertumbuhan lebih cepat. Itik periode pertumbuhan dipelihara secara semi intensif memanfaatkan sumber pakan lokal yaitu Azola, keladi, enceng gondok, padi ampo ditambah dengan dedak, jagung, bekicot dan limbah pengolahan pensi sehingga harga pakan bisa lebih murah. Untuk meningkatkan kesehatan ternak dan mengurangi bau kandang diberikan probiotik secara teratur. Pengolahan pascapanen dilakukan dengan memberikan beberapa inovasi pada pengolahan telur dan daging itik menjadi rendang suir, rendang telur, aneka varian telur asin yang bisa meningkatkan kesehatan dan pendapatan masyarakat. Berdasarkan hasil kegiatan yang telah dilakukan dapat disimpulkan bahwa mendapat respon yang baik bagi masyarakat sasaran dan pemerintah daerah, khususnya di lingkungan kecamatan Batipuh Kabupaten Tanah Datar.
INKUBASI INDUSTRI MIKRO DAN BADAN USAHA MILIK NAGARI DI NAGARI SUNGAI KAMUYANG
Authors: Games Donard , Sari Dessy Kurnia
Published: June 2022

Inkubasi menjadi suatu kebutuhan untuk meningkatkan kinerja industri mikro dan kecil. Produk-produk yang berasal dari Nagari Sungai Kamuyang memiliki potensi untuk dikembangkan lebih lanjut. Namun demikian, belum ada proses inkubasi yang secara sistematis dan jelas memberikan masukan berupa strategi inovasi yang bisa meningkatkan kinerja organisasi. Kegiatan ini bertujuan untuk menyediakan wadah untuk industri untuk meningkatkan strategi inovasi dan kinerja organisasi. Pada kegiatan ini terdapat tiga industri kecil dan mikro yang menjadi tenant atau incubatee, yaitu usaha rendang, usaha kerupuk ubi jengkol, dan usaha aneka kue. Selain itu pelaksanaan inkubasi juga dilakukan pada Badan Usaha Milik Nagari Sungai Kamuyang dalam rangka meningkatkan kinerja organisasi melalui peran institusi ini untuk memperkuat industri mikro dan kecil di Nagari Sungai Kamuyang. Inkubasi dilakukan oleh dosen-dosen Program Studi Manajemen Universitas Andalas yang berasal dari beragam disiplin ilmu, yaitu manajemen keuangan, kewirausahaan, manajemen pemasaran, dan manajemen sumber daya manusia. Hasil kegiatan yang diperoleh adalah untuk pemberdayaan ekonomi Nagari Sungai Kamuyang membutuhkan usaha mikro dan kecil yang bertumbuh. Kegiatan ini dilakukan dengan coaching dan mentoring yang dilakukan para dosen secara langsung dengan tiga pelaku usaha. Hasilnya berupa masukan yang komprehensif dari beragam disiplin ilmu dan ini berkelanjutan dengan memberikan proses diskusi (coaching dan mentoring).  Tiga usaha mikro yang menjadi tenant inkubasi ini memiliki kendala dalam hal standardisasi, pemasaran, inovasi produk, serta strategi bisnis dan manajemen pengelolaan bisnis secara keseluruhan. Kegiatan yang dilakukan oleh PSM ini sudah berupaya melakukan inkubasi dengan membagi dosen dengan beragam keahlian tenant. Diharapkan ada rekomendasi dan proses lanjutan yang bisa mengevaluasi dan menindaklanjuti rekomendasi tersebut.
INTRODUKSI PEMBUATAN WASTAFEL PORTABEL SISTEM INJAK UNTUK PENCEGAHAN COVID-19 DI NAGARI TARANTANG KABUPATEN LIMAPULUH KOTA
Authors: Iryani Nelvia , Sufiawan Nur Ari , Ahmad Faisal Ali , Alfikri Alfikri
Published: June 2022

Nagari Tarantang merupakan salah satu nagari yang terletak di Kecamatan Harau Kabupaten Limapuluh Kota. Bertani dan berkebun menjadi mata pencaharian utama penduduknya. Selain itu, alam hijau yang menyelimuti lembah dan tebing menjadikan nagari Tarantang menjadi salah destinasi wisata terkenal yaitu Kawasan Wisata Lembah Harau. Kegiatan ini bertujuan untuk membantu Nagari Tarantang dalam memutus rantai penyebaran Covid-19 terutama di area publik seperti kawasan wisata Lembah Harau, masjid, dan kantor-kantor pemerintahan nagari dengan mensosialisasikan penggunaan wastafel portabel sistem injak kepada masyarakat dan wisatawan yang berkunjung ke daerah tersebut. Guna mencapai tujuan tersebut maka metode yang digunakan pada kegiatan ini adalah dengan mengadakan sosialisasi tentang pentingnya penggunaan wastafel portabel sistem injak kepada masyarakat Nagari Tarantang. Pelaksanaan kegiatan ini dilakukan secara intensif, terarah dan bertahap. Tahapan dan metode yang digunakan yaitu: 1. Tahap Pemenuhan Perlengkapan, 2. Tahap Pembuatan, dan 3. Tahap Penyerahan. Hasil kegiatan yang diperoleh semua rangkaian kegiatan ini berjalan dengan baik. Seluruh peserta penyuluhan mendapatkan pengetahuan akan pentingnya mencuci tangan untuk memutus rantai penyebaran virus Covi-19 di Nagari Tarantang. Disamping itu telah membantu membuatkan beberapa wastafel portabel sistem injak untuk ditempatkan di area publik seperti kawasan wisata Lembah Harau, masjid, dan kantor Walinagari Tarantang. Dengan selesainya kegiatan ini, diharapkan masyarakat dan pengunjung objek wisata Lembah Harau dapat menggunakan wastafel portabel sistem injak untuk mencuci tangan sebelum dan sesudah memasuki Kawasan Wisata Lembah Harau serta area-area publik di Nagari Tarantang seperti kawasan wisata Lembah Harau, masjid, dan kantor Walinagari Tarantang.
APLIKASI PENGELOLAAN HAMA TERPADU KUMBANG TANDUK (ORYCTES RHINOCEROS L.) PADA KELAPA SAWIT DI NAGARI GIRI MAJU KABUPATEN PASAMAN BARAT
Authors: Efendi Siska
Published: June 2022

Kelapa sawit yang dibudidayakan pada areal replanting tidak tumbuh optimal karena sebagian besar diserang kumbang tanduk (Oryctes rhinoceros L.). Persentase serangan kumbang tanduk tergolong tinggi yakni 80% pada tanaman umur 3 tahun dan 100% pada umur 1-1.5 tahun. Diketahui limbah sisa replanting menjadi penyebab tingginya populasi kumbang tanduk karena batang kelapa sawit yang membusuk menjadi habitat yang cocok untuk perkembangan kumbang tanduk. Untuk mengatasi permasalahan yang dihadapi mitra diaplikasikan Pengelolaan Hama Terpadu (PHT). Komponen PHT yang akan diaplikasikan yakni kultur teknis, mekanis, serta pengendalian semiokimia dengan feromon. Kegiatan ini bertujuan untuk mengurangi tingkat kerusakan hama kumbang tanduk pada tanaman kelapa sawit pasca replanting. Kegiatan ini dilakukan dengan metode penyuluhan, pelatihan, demplot (percontohan), pemberian bantuan alat dan mesin, serta monitoring dan evaluasi. Hasil kegiatan diperoleh bahwa mitra mampu penerapan pengelolaan hama terpadu (PHT) secara mandiri di lahan masing-masing. Rakitan teknologi PHT yang sudah diaplikasikan dapat menurunkan tingkat serangan kumbang tanduk dari 86.68% menjadi 79.60%. Sampai saat ini perangkat PHT masih terpasang dan dioperasikan kelompok tani mitra. Aplikasi PHT di lokasi demplot secara nyata dapat menurunkan populasi kumbang tanduk, begitu juga tidak terlihat lagi gejala baru tanaman yang terserang.Aplikasi PHT yang berkelanjutan, meliputi lahan dengan skala luas, melibatkan semua pelaku usaha kelapa sawit akan meningkatkan peluang keberhasilan metode tersebut di masa yang akan datang.
PELATIHAN PENGOLAHAN MAKANAN BERBAHAN KHAS SUMBER ALAM NAGARI AMPIANG PARAK PESISIR SELATAN
Authors: Sarfika Rika , Anggraini Ezi , Silvana Meza , Mahzelfi Ihsani
Published: June 2022

Processing natural foodstuffs such as seafood require special skills to produce processed products of high selling value. The purpose of the activity is to conduct training in processing food from natural ingredients into healthy snacks. This activity was attended by UMKM Umi Wiwik and the community in the Padang Tae village, Kenagarian Ampiang Parak Pesisir Selatan. The method is carried out through 4 stages; socialization, demonstration, mentoring, dan evaluation. The training materials provided are in the form of explanations about healthy food ingredients, how to process food from fish and seashells, and how to serve and package processed foods. The training was carried out for 8 hours provided by a culinary expert (chef). The activities resulted in various healthy snack products made by partners with recipes provided by the chef, such as fish pilus, fish sticks, meatballs seashell, and nuggets seashell. Based on the results, the activity implementation team and partners agreed to plan further activities to procure socialization about marketing and business management and business development into a legal entity business.
PENERAPAN SISTEM DIGITALISASI PADA UMKM DI DESA LUBUK PINANG KABUPATEN MUKO-MUKO, BENGKULU
Authors: Praja Pery , Syaiful Ferry Lismanto
Published: June 2022

Dalam dunia bisnis ada beberapa faktor yang menentukan keberhasilan daya saing pasar dan keberlangsungan hidup dari bisnis yang bersangkutan. Dengan adanya kehadiran Pandemi Covid-19 telah membuat mayoritas sektor ekonomi terutama UMKM menjadi stagnan. Banyaknya pelaku UMKM yang pada akhirnya harus tutup toko atau bangkrut dikarenakan ketidakmampuan beradaptasi dalam memilih strategi penjualan dan operasional yang tepat selama masa Pandemi Covid-19. Maka dari itu pelaku UMKM harus mampu beradaptasi secara cepat dan tepat dalam menghadapi dampak buruk dari Pandemi Covid-19 bagi pelaku UMKM yang sedang menekuni bisnis mereka, serta pelaku UMKM hendaknya mampu dalam menentukan strategi pemasran yang tepat dalam mengimbangi perubahan pola konsumtif konsumen saat sekarang ini. Digitalisasi UMKM merupakan cara terkini dan ampuh dalam mengurangi kemungkinan kerugian yang diderita oleh pelaku UMKM serta bisa menjadi cara yang efektif dalam menstabilkan serta meningkatkan keuntungan pada pelaku bisnis Usaha Mikro Kecil Menengah (UMKM). Tujuan kegiatan ini adalah 1. meningkatkan pengetahuan dan pemahaman pelaku UMKM dalam memanfaatkan sosial media sebagai media pemasaran yang efektif, 2. meningkatkan pengetahuan dan pemahaman pelaku UMKM dalam memanfaatkan aplikasi pembukuan digital untuk meningkatkan efektivitas dari kegiatan keuangan bisnis. Kegiatan ini telah dilakukan di Desa Lubuk Pinang Kabupaten Mukomuko. Sasaran dari kegiatan ini adalah  pelaku UMKM di Desa Lubuk Pinang Kabupaten Mukomuko tersebut. Metode yang digunakan ialah beruapa penyuluhan, pelatihan dan monitoring/evaluasi. Hasil yang diperoleh dari kegiatan ini adalah telah cukup pahamnya pelaku UMKM dalam menentukan strategi pemasaran yang tepat selama masa Pandemi Covid-19 serta kemampuan dalam menggunakan aplikasi smartphone pembantu dalam kegiatan operasional bisnisnya. Dari hasil yang diperolah dapat disimpulkan bahwa pemanfaatan sistem digitalisasi dalam kegiatan berbisnis pada sektor UMKM dapat mengurangi kerugian dan meningkatkan penjualan.
PENERAPAN TEKNOLOGI PENGOLAHAN SAMPAH ORGANIK BERBASIS ZERO WASTE YANG BERNILAI EKONOMIS DI SUMATERA BARAT
Authors: Novia Deni , Amizar Robi , Fitrimawati Fitrimawati , Syafrizayanti Syafrizayanti
Published: June 2022

Sampah plastik mendapat perhatian khusus untuk mengatasinya namun sampah yang terbesar di tempat pembuangan akhir (TPA) adalah sampah organik sekitar 60% mendominasi jumlah sampah yang ada. Sampah organik jika diolah dan dimanfaatkan untuk kehidupan sehari-hari malah dapat memberikan penghasilan tambahan jika diseriuskan. Tujuan dari kegiatan ini adalah memberikan bekalan pengetahuan dan keterampilan tenaga pendamping Mitra organisasi wanita, terutama dari mahasiswa yang berdomisili di Sumatera Barat, tentang zero waste sehingga dapat mengolah sampah organik menjadi beberapa produk yang bermanfaat dan bernilai ekonomis skala rumah tangga. Adapun metode kegiatan adalah pengarahan, penyuluhan / penyadaran/sosialisasi, pelatihan, pendampingan dan konsultasi bisnis. Adapun tahapan pelaksanaannya adalah 1) perencanaan kegiatan yang tepat sesuai kebutuhan Mitra, 2) webinar pendampingan, 3) pelatihan dan 4) evaluasi. Berdasarkan kegiatan yang telah dilaksanakan dapat disimpulkan bahwa 1) Mitra memerlukan tenaga pendamping untuk menuntaskan masalah sampah di rumah tangga-rumah tangga mitra, 2) Kegiatan Webinar pendampingan zero waste telah dilaksanakan secara daring menggunakan aplikasi Zoom yang diikuti oleh lebih dari 108 orang peserta yang berasal dari mahasiswa dan umum dengan penuh antusias oleh tiga orang pemateri sekaligus praktisi handal dibidangnya masing-masing dengan topik eco enzyme, mikroorganisme lokal (MOL), sampah – maggot – kompos. 3) Peserta sangat terkesan dengan webinar zero waste dan minta ditindak lanjuti pelaksanaan webinar lainnya. 4) Kegiatan pelatihan eco enzyme, MOL dan kompos dilaksanakan secara offline dan kunjungan ke Minagot.
Feasibility Study of Canned Smoked Fish as the Micro Enterprises in South Sumatra Province, Indonesia
Authors: Hasmawaty  , Kusmindari Christofora Desi , Faizal Muhammad
Published: June 2022

This paper analyzes several aspects (technical, marketing, economic, social, and financial) of canned smoked fish (Pangasius) as a micro-industry in South Sumatra Province, Indonesia. This article adopts mix-methods. A quantitative method is used to explain technical, marketing, economic, and financial aspects, while the social aspect is explained using a qualitative method. The author collects the Pangasius species sample from nine districts in South Sumatra Province for the technical aspect. This sample transformed into canned smoked fish using several steps: preparation, making and cooking, filling process, exhausting, sealing sterilization, and cooling process. The author also collects secondary data and interviews several key informants to analyze the non-technical aspect of the canned smoked fish industry. A canned smoked fish (Pangasius) has excellent potential to develop as a micro-enterprise in South Sumatra, Indonesia. In the long-term, it could be an instrument for the local government to increase citizens' well-being based on local resources and penetrate the ASEAN free trade area. In a short time, it could be an instrument for the local government to manage the economic effect of COVID-19 in South Sumatera, Indonesia. This study could be a baseline for the government to create a policy for developing the smoked fish industry. The result of this study could be a second opinion in planning capital investment within the smoked fish industry at the SSP for the investor and the entrepreneur.
Optimization of Gear Manufacturing for Quality and Productivity
Authors: TC Phokane
Published: June 2022

Multi-objective optimization in manufacturing can effectively be solved using Multicriteria decision-making (MCDM) techniques. This paper presents the implementation methodology of the Fuzzy-MOORA hybrid technique for multi-objective optimization in laser machining of stainless-steel gears. Further, simultaneous optimization of gear quality and process productivity have been reported. Four important laser parameters, i.e., laser power, cutting speed, focal position, and gas pressure, have varied during twenty-nine experiments to machine gears by a laser process. The quality of miniature gear was measured in terms of average surface roughness, mean roughness depth, and dimensional deviation. The productivity of the laser machining process was estimated via material removal rate. An optimum set of laser machining parameters obtained after Fuzzy-MOORA optimization is laser power 2000 W, cutting speed 3 m/min, focal position -2.5 mm, and gas pressure 16 bar. This work encourages researchers and scholars to make further attempts using such MCDM techniques to develop intelligent processes in industrial and manufacturing engineering.