bluuebunny/crossref_metadata_2025 huggingface dataset:
Fit Testing Disposable P2/N95 Respirators during COVID-19 in Victoria, Australia: Fit Check Evaluation, Failure Rates, and a Survey of Healthcare Workers
Authors: Chan Jun Keat , Yep Kah Hong , Magarey Sarah , Keon-Cohen Zoe , Acheson Matt
Published: July 2021

Quantitative fit testing was utilised to evaluate the Department of Health and Human Services in Victoria (DHHS) recommended fit check and determine pass/fail rates for self-selected P2/N95 respirators. Survey experience and training related to P2/N95 respirators were also obtained. This was an observational study at a specialist tertiary referral centre, Melbourne, Australia, between 29 May 2020 and 5 June 2020. The primary outcome was quantitative fit test pass/fail results, with fit check reported against fit test as a 2 × 2 contingency table. The secondary outcomes were the number of adjustments needed to pass, as well as the pass rates for available sizes and types of self-selected respirators, survey data for attitudes, experience and training for P2/N95 respirators. The fit check predicts respirator seal poorly (PPV 34.1%, 95% CI 25.0–40.5). In total, 69% (40/58) of respirators failed quantitative fit testing after initial respirator application and is a clinically relevant finding (first-up failure rate for P2/N95 respirators). Only one person failed the fit test for all three respirator fit tests. There was significant variability between each of the seven types of self-selected P2/N95 respirators, although sample sizes were small. Few participants were trained in the use of P2/N95 respirators or the fit check prior to COVID-19, with a high number of participants confident in achieving a P2/95 respirator seal following a fit test. The fit check alone was not a validated method in confirming an adequate seal for P2/N95 respirators. Quantitative fit testing can facilitate education, improve the seal of P2/N95 respirators, and needs to be integrated into a comprehensive Respiratory Protection Program (RPP).
Electric Double Layer Doping of Charge-Ordered Insulators α-(BEDT-TTF)2I3 and α-(BETS)2I3
Authors: Kawasugi Yoshitaka , Masuda Hikaru , Pu Jiang , Takenobu Taishi , Yamamoto Hiroshi M. , Kato Reizo , Tajima Naoya
Published: July 2021

Field-effect transistors based on strongly correlated insulators are an excellent platform for studying the electronic phase transition and simultaneously developing phase transition transistors. Molecular conductors are suitable for phase transition transistors owing to the high tunability of the electronic states. Molecular Mott transistors show field-induced phase transitions including superconducting transitions. However, their application to charge-ordered insulators is limited. In this study, we fabricated electric double layer transistors based on quarter-filled charge-ordered insulators α-(BEDT-TTF)2I3 and α-(BETS)2I3. We observed ambipolar field effects in both compounds where both electron and hole doping (up to the order of 1013 cm−2) reduces the resistance by the band filling shift from the commensurate value. The maximum field-effect mobilities are approximately 10 and 55 cm2/Vs, and the gate-induced conductivities are 0.96 and 3.6 e2/h in α-(BEDT-TTF)2I3 and α-(BETS)2I3, respectively. However, gate-induced metallic conduction does not emerge. The gate voltage dependence of the activation energy in α-(BEDT-TTF)2I3 and the Hall resistance in α-(BETS)2I3 imply that the electric double layer doping in the present experimental setup induces hopping transport rather than band-like two-dimensional transport.
Impact of Lesion Delineation and Intensity Quantisation on the Stability of Texture Features from Lung Nodules on CT: A Reproducible Study
Authors: Bianconi Francesco , Fravolini Mario Luca , Palumbo Isabella , Pascoletti Giulia , Nuvoli Susanna , Rondini Maria , Spanu Angela , Palumbo Barbara
Published: July 2021

Computer-assisted analysis of three-dimensional imaging data (radiomics) has received a lot of research attention as a possible means to improve the management of patients with lung cancer. Building robust predictive models for clinical decision making requires the imaging features to be stable enough to changes in the acquisition and extraction settings. Experimenting on 517 lung lesions from a cohort of 207 patients, we assessed the stability of 88 texture features from the following classes: first-order (13 features), Grey-level Co-Occurrence Matrix (24), Grey-level Difference Matrix (14), Grey-level Run-length Matrix (16), Grey-level Size Zone Matrix (16) and Neighbouring Grey-tone Difference Matrix (five). The analysis was based on a public dataset of lung nodules and open-access routines for feature extraction, which makes the study fully reproducible. Our results identified 30 features that had good or excellent stability relative to lesion delineation, 28 to intensity quantisation and 18 to both. We conclude that selecting the right set of imaging features is critical for building clinical predictive models, particularly when changes in lesion delineation and/or intensity quantisation are involved.
Diagnosis of Pneumonia Due to Invasive Molds
Authors: Foppiano Palacios Carlo , Spichler Moffarah Anne
Published: July 2021

Pneumonia is the most common presentation of invasive mold infections (IMIs), and is pathogenetically characterized as angioinvasion by hyphae, resulting in tissue infarction and necrosis. Aspergillus species are the typical etiologic cause of mold pneumonia, with A. fumigatus in most cases, followed by the Mucorales species. Typical populations at risk include hematologic cancer patients on chemotherapy, bone marrow and solid organ transplant patients, and patients on immunosuppressive medications. Invasive lung disease due to molds is challenging to definitively diagnose based on clinical features and imaging findings alone, as these methods are nonspecific. Etiologic laboratory testing is limited to insensitive culture techniques, non-specific and not readily available PCR, and tissue biopsies, which are often difficult to obtain and impact on the clinical fragility of patients. Microbiologic/mycologic analysis has limited sensitivity and may not be sufficiently timely to be actionable. Due to the inadequacy of current diagnostics, clinicians should consider a combination of diagnostic modalities to prevent morbidity in patients with mold pneumonia. Diagnosis of IMIs requires improvement, and the availability of noninvasive methods such as fungal biomarkers, microbial cell-free DNA sequencing, and metabolomics-breath testing could represent a new era of timely diagnosis and early treatment of mold pneumonia.
VEGF-Targeted Multispectral Optoacoustic Tomography and Fluorescence Molecular Imaging in Human Carotid Atherosclerotic Plaques
Authors: Steinkamp Pieter J. , Vonk Jasper , Huisman Lydian A. , Meersma Gert-Jan , Diercks Gilles F. H. , Hillebrands Jan-Luuk , Nagengast Wouter B. , Zeebregts Clark J. , Slart Riemer H. J. A. , Boersma Hendrikus H. , van Dam Gooitzen M.
Published: July 2021

Vulnerable atherosclerotic carotid plaques are prone to rupture, resulting in ischemic strokes. In contrast to radiological imaging techniques, molecular imaging techniques have the potential to assess plaque vulnerability by visualizing diseases-specific biomarkers. A risk factor for rupture is intra-plaque neovascularization, which is characterized by overexpression of vascular endothelial growth factor-A (VEGF-A). Here, we study if administration of bevacizumab-800CW, a near-infrared tracer targeting VEGF-A, is safe and if molecular assessment of atherosclerotic carotid plaques in vivo is possible using multispectral optoacoustic tomography (MSOT). Healthy volunteers and patients with symptomatic carotid artery stenosis scheduled for carotid artery endarterectomy were imaged with MSOT. Secondly, patients were imaged two days after intravenous administration of 4.5 bevacizumab-800CW. Ex vivo fluorescence molecular imaging of the surgically removed plaque specimen was performed and correlated with histopathology. In this first-in-human MSOT and fluorescence molecular imaging study, we show that administration of 4.5 mg bevacizumab-800CW appeared to be safe in five patients and accumulated in the carotid atherosclerotic plaque. Although we could visualize the carotid bifurcation area in all subjects using MSOT, bevacizumab-800CW-resolved signal could not be detected with MSOT in the patients. Future studies should evaluate tracer safety, higher doses of bevacizumab-800CW or develop dedicated contrast agents for carotid atherosclerotic plaque assessment using MSOT.
Evaluation of VIDAS® Diagnostic Assay Prototypes Detecting Dengue Virus NS1 Antigen and Anti-Dengue Virus IgM and IgG Antibodies
Authors: Somlor Somphavanh , Brossault Ludovic , Grandadam Marc
Published: July 2021

Dengue is a serious tropical disease caused by the mosquito-borne dengue virus (DENV). Performant, rapid, and easy-to-use assays are needed for the accurate diagnosis of acute DENV infection. We evaluated the performance of three prototype assays developed for the VIDAS® automated platform to detect dengue NS1 antigen and anti-dengue IgM and IgG antibodies. Positive and negative agreement with competitor enzyme-linked immunosorbent assays (ELISA) and rapid diagnostic tests (RDT) was evaluated in 91 Lao patients (57 adults, 34 children) with acute DENV infection. The VIDAS® NS1 assay showed the best overall agreement (95.6%) with the competitor NS1 ELISA. Both VIDAS® NS1 and NS1 ELISA assays also demonstrated high sensitivity relative to DENV RNA RT-PCR set as gold standard (85.7% and 83.9%, respectively). In contrast, NS1 RDT was less sensitive relative to DENV RNA RT-PCR (72.7%). The overall agreement of VIDAS® IgM and IgG assays with the competitor assays was moderate (72.5% for IgM ELISA, 76.9% for IgG ELISA, and 68.7% for IgM and IgG RDT). In most analyses, test agreements of the VIDAS® assays were comparable in adults and children. Altogether, the VIDAS® dengue prototypes performed very well and appear to be suitable for routine detection of dengue NS1 antigen and anti-dengue IgM/IgG antibodies.
Analysis and Design of a Microphone Preamplifier for Mobile Applications
Authors: Im Saemin , Park Sang-Gyu
Published: July 2021

A design of an on-chip ac-coupling preamplifier for mobile applications is presented. A microphone preamplifier should have a large input impedance to mitigate the effective-gain reduction caused by the microphone’s non-zero output impedance. From a review of previously reported microphone preamplifier structures in terms of input impedance, feasibility of on-chip ac-coupling, and noise performance, we chose an inverting amplifier structure with capacitive feedback. In addition, to provide dc bias path, we used off-state MOSFET switches as pseudo-resistors of very large resistance in the giga-ohm range. The large resistance enables on-chip ac-coupling with sufficient noise performance. A fast start-up is achieved by turning-on the switch for a short period during the preamplifier start-up. The gain of the preamplifier can be programmed from 0 dB to 21 dB with 3 dB steps. A 2-stage pseudo-class-AB amplifier was adopted to reduce power consumption. The proposed preamplifier was implemented using a 28 nm CMOS process and achieves 107 dB dynamic range in a 20 kHz bandwidth under 0 dB gain setting and balanced differential input signal. The preamplifier dissipates a power of 270 μW with a 1.8 V supply.
Evaluation of Integrated Concepts with CO2 for Heating, Cooling and Hot Water Production
Authors: Smitt Silje , Pardiñas Ángel , Hafner Armin
Published: July 2021

The hotel sector is characterized by high thermal demands and a large carbon footprint, which greatly contributes to the global warming effect. Consequently, there is a need to investigate solutions that can reduce energy usage within this sector by means of environmentally friendly and sustainable technologies. Integrated CO2 heat pump systems for heating, cooling, and hot water production in hotels have demonstrated promising results. This paper theoretically compares the energy consumption, environmental impact, and cost of three different design concepts for integrated CO2 units equipped with thermal storage. The main characteristics of the evaluated designs are single-stage compression, parallel compression, and ejector-supported parallel compression. Furthermore, two separate hot water charging strategies were implemented and investigated over a large span of ambient temperatures and loads. The evaluations were carried out by considering eight different European locations, ranging from Scandinavia to the Mediterranean. The results revealed that the ejector-supported parallel compression design was superior in terms of annual COP, which was found to be in the range of 4.27 to 5.01 for the Scandinavian locations and 5.03 to 5.71 for the other European locations. When accounting for investment cost and electricity prices, the payback period at the Scandinavian locations was 6.3 to 7.7 years. Payback periods of 3 and 4.5 to 7.5 were obtained for hotels located in the temperate and Mediterranean climates, respectively. The investigation also revealed that the hot water charging strategy, rather than the specific CO2 heat pump design, is the least expensive measure to enhance performance.
An Effective Acoustic Impedance Imaging Based on a Broadband Gaussian Beam Migration
Authors: Liu Shaoyong , Zhu Wenting , Yan Zhe , Xu Peng , Wang Huazhong
Published: July 2021

The estimation of the subsurface acoustic impedance (AI) model is an important step of seismic data processing for oil and gas exploration. The full waveform inversion (FWI) is a powerful way to invert the subsurface parameters with surface acquired seismic data. Nevertheless, the strong nonlinear relationship between the seismic data and the subsurface model will cause nonconvergence and unstable problems in practice. To divide the nonlinear inversion into some more linear steps, a 2D AI inversion imaging method is proposed to estimate the broadband AI model based on a broadband reflectivity. Firstly, a novel scheme based on Gaussian beam migration (GBM) is proposed to produce the point spread function (PSF) and conventional image of the subsurface. Then, the broadband reflectivity can be obtained by implementing deconvolution on the image with respect to the calculated PSF. Assuming that the low-wavenumber part of the AI model can be deduced by the background velocity, we implemented the AI inversion imaging scheme by merging the obtained broadband reflectivity as the high-wavenumber part of the AI model and produced a broadband AI result. The developed broadband migration based on GBM as the computational hotspot of the proposed 2D AI inversion imaging includes only two GBM and one Gaussian beam demigraton (Born modeling) processes. Hence, the developed broadband GBM is more efficient than the broadband imaging using the least-squares migrations (LSMs) that require multiple iterations (every iteration includes one Born modeling and one migration process) to minimize the objective function of data residuals. Numerical examples of both synthetic data and field data have demonstrated the validity and application potential of the proposed method.
Effect of Various Wafer Surface Etching Processes on c-Si Solar Cell Characteristics
Authors: Park Jeong Eun , Han Chang-Soon , Choi Won Seok , Lim Donggun
Published: July 2021

In order to analyze the effects of various sizes of pyramid structure on solar cell characteristics, a pyramid structure was formed on the wafer through various etching processes. In this paper, etching was performed using one-step etching processes such as alkaline solution etching, reactive ion etching (RIE), and metal-assisted chemical etching (MACE), and two-step etching processes such as alkaline solution + MACE and alkaline solution + RIE. The micro-sized pyramid-structured wafers formed using the alkali solution showed higher reflectivity than nano-sized pyramid-structured wafers. Accordingly, it was expected that the characteristics of the cells fabricated with a nano-sized pyramid-structured wafer having low reflectivity would be higher than that of a micro-sized pyramid-structured wafer. However, it was confirmed that the quantum efficiency characteristics in the short wavelength region were higher in the micro-sized pyramid-structured wafers than in the nano-sized pyramid-structured wafers. To confirm the reason for this, surface characteristics were analyzed through the deposition of an emitter layer on a wafer formed in a pyramidal structure. As a result, in the case of the nano-sized pyramid-structured wafer, the sheet resistance characteristics were lower due to the increased depth of the emitter layer in comparison to the micro-sized pyramid-structured wafer. Accordingly, it was determined that the quantum efficiency was degraded as a result of the high recombination rate.
CoKnowEMe: An Edge Evaluation Scheme for QoS of IoMT Microservices in 6G Scenario
Authors: Aiosa Grazia Veronica , Attanasio Barbara , La Corte Aurelio , Scatá Marialisa
Published: July 2021

The forthcoming 6G will attempt to rewrite the communication networks’ perspective focusing on a shift in paradigm in the way technologies and services are conceived, integrated and used. In this viewpoint, the Internet of Medical Things (IoMT) represents a merger of medical devices and health applications that are connected through networks, introducing an important change in managing the disease, treatments and diagnosis, reducing costs and faults. In 6G, the edge intelligence moves the innovative abilities from the central cloud to the edge and jointly with the complex systems approach will enable the development of a new category of lightweight applications as microservices. It requires edge intelligence also for the service evaluation in order to introduce the same degree of adaptability. We propose a new evaluation model, called CoKnowEMe (context knowledge evaluation model), by introducing an architectural and analytical scheme, modeled following a complex and dynamical approach, consisting of three inter-operable level and different networked attributes, to quantify the quality of IoMT microservices depending on a changeable context of use. We conduct simulations to display and quantify the structural complex properties and performance statistical estimators. We select and classify suitable attributes through a further detailed procedure in a supplementary information document.
Ignition of Fuel Beds by Cigarettes: A Conceptual Model to Assess Fuel Bed Moisture Content and Wind Velocity Effect on the Ignition Time and Probability
Authors: Viegas Domingos Xavier , Oliveira Ricardo , Almeida Miguel , Kim Donghyun
Published: July 2021

A conceptual model based on the balance of energy in a system composed of a burning cigarette, ambient flow and a porous fuel bed is proposed to study the burning of a single cigarette and the process of fuel bed dehydration, pyrolysis and its eventual ignition or combustion extinction. Model predictions of time to ignition and of the probability of ignition as a function of fuel bed moisture content and ambient flow velocity are compared with results obtained in laboratory ignition tests of straw fuel beds for various ambient conditions. According to this study, the main parameters influencing the models developed are the fuel bed and tobacco moisture content, as well as the flow velocity.
Fruit Quality Characteristics and Biochemical Composition of Fully Ripe Blackberries Harvested at Different Times
Authors: Mikulic-Petkovsek Maja , Veberic Robert , Hudina Metka , Zorenc Zala , Koron Darinka , Senica Mateja
Published: July 2021

We investigated how the quality of blackberry fruit changes during the ripening period. Since it is difficult to predict picking dates for blackberries, we were interested in how the quality of fully ripe fruit changed depending on the sampling date (from 28 July to 1 September). Blackberries (at full ripeness) were sampled at six weekly intervals and the contents of sugars, vitamin C, organic acids and phenolic components were analysed by high performance liquid chromatography combined with mass spectrometry. The colour parameters, total soluble solids and weight of the fruits were also measured. The results showed that the fruits at the last sampling had a significantly lower fruit weight and higher soluble solids. ‘Cacanska Bestrna’ had the highest fruit weight and vitamin C content (11.43 mg/100 g). The main sugars in blackberries were fructose (13.8–33.4 g/kg FW) and glucose (13.0–33.2 g/kg FW). ‘Loch Ness’ and ‘Navaho’ had a sweeter taste since they had the highest ratio of sugars and acids (S/A approx. 5.8) and ‘Smoothstem’ and ‘Thornfree’ had the sourest taste, with a ratio of S/A 2.5. Blackberries harvested at the first two samplings had lower anthocyanin contents than fruits from later sampling times. There were no significant differences in the content of flavonols, ellagitannins, flavanols or hydroxycinnamic acids during the ripening period. The content of vitamin C in the fruits did not change among samplings, but the fruits had a higher content of organic acids at the first two or three samplings. The results may be useful for both the processing industry and growers to set quality standards for each variety and to determine the optimal harvest time.
Best Papers Introduction
Authors: Archbold Douglas D.
Published: July 2021

I am pleased to draw attention to two papers published in Horticulture in 2019 which the Editorial Board has recognized as worthy of special attention as “Best Papers of 2019”, among the many excellent papers from that year [...]
Golfers’ Interest in Multilevel Sun-Protection Strategies
Authors: Weikert Amanda E. , Pagoto Sherry L. , Handley Eric , Courtney Jimikaye B. , Brunke-Reese Deborah , Conroy David E.
Published: July 2021

Active adults accumulate more ultraviolet (UV) radiation exposure and are at greater risk of skin cancer than inactive adults. Golf is a popular sport that increases UV exposure because it is played outdoors in daylight. This study evaluated adult golfers’ interest in multilevel sun-protection strategies and characterized differences in interest as a function of golfer characteristics. Adult golfers (N = 347) completed a web survey to rate their interest in 20 sun-protection strategies. We estimated descriptive statistics and evaluated differences in interest as a function of demographics, perceived risk, sun-protective behavior, and golf exposure. Golfers reported the greatest interest in environmental supports for sun protection, but these ratings were driven by golfers who already perceived golf as a risk behavior and used sunscreen diligently. Vulnerable golfers—those with a golf-related sunburn in the past year or who spend more time golfing—expressed interest in a broader range of intervention components, including education, family support, and text messages. Multilevel skin cancer prevention interventions are needed for golfers. Intervention components of interest involved support and reminders, which suggests they are open to sun-safety behaviors but need help executing them.
Explicit and Intrinsic Intention to Receive COVID-19 Vaccination among Heterosexuals and Sexual Minorities in Taiwan
Authors: Lin Yen-Ju , Chang Yu-Ping , Chou Wen-Jiun , Yen Cheng-Fang
Published: July 2021

The present study compared the levels of explicit and intrinsic intention to receive COVID-19 vaccination among sexual minority and heterosexual individuals and examined the association of explicit and intrinsic intentions with sexual orientation. We enrolled 171 sexual minority and 876 heterosexual individuals through a Facebook advertisement. The participants’ explicit and intrinsic intentions to receive COVID-19 vaccination and their risk perception of COVID-19 were measured. We discovered that sexual minority individuals had higher levels of explicit and intrinsic intention to receive vaccination relative to heterosexual individuals. Intrinsic intention was positively associated with explicit intention after the effects of demographic characteristics and risk perception of COVID-19 were controlled for. Sexual orientation did not moderate the association between explicit and intrinsic intentions. The present study determined the relationship between sexual orientation and intention to receive COVID-19 vaccination.
A Cross-Cultural Study of Distress during COVID-19 Pandemic: Some Protective and Risk Factors
Authors: Kosic Ankica , Džamonja Ignjatović Tamara , Petrović Nebojša
Published: July 2021

Previous studies on the impact of the COVID-19 pandemic on mental health in different countries found an increase in anxiety, stress, and an exacerbation of previous mental health problems. This research investigated some of the protective and risk factors of distress during the COVID-19 pandemic, among which were the perception of receiving social support from family members and friends, and a chronic tendency to worry. The study was conducted in three European countries: Italy, Serbia, and Romania. A total of 1100 participants (Italy n = 491; Serbia n = 297; Romania n = 312) responded to a questionnaire. Results from this study show that distress during the COVID-19 pandemic is higher for people who are chronic worriers and those who have higher levels of fear of COVID-19. More specifically, it is confirmed that a chronic tendency to worry exacerbates the relationship between fear and distress: it is stronger for people who have a greater tendency to worry.
Understanding Tourist Behavioural Intention When Faced with Smog Pollution: Focus on International Tourists to Beijing
Authors: Ruan Wenjia-Jasmine , Lee Junjae , Song Hakjun
Published: July 2021

This study examines the behavioural intentions of international tourists travelling to Beijing when faced with smog pollution. An extended MGB (model of goal-directed behaviour) was employed as the theoretical framework by integrating mass-media effect and perception of smog. The role of mass-media effect and perception of smog were considered as new variables in the international tourist’s decision-making process for travel to Beijing. Structural equation modelling (SEM) was employed to identify the structural relationships among research variables. Our research results showed a strong correlation between positive anticipated emotion and desire. The mass-media effect is a significant (direct) predictor of both the perception of smog and behavioural intention. The Chinese government could attach great importance to the mass-media effect to reduce the negative impact caused by smog pollution on inbound tourism.
TMD in Females with Menstrual Disorders
Authors: Jedynak Bożena , Jaworska-Zaremba Marta , Grzechocińska Barbara , Chmurska Magdalena , Janicka Justyna , Kostrzewa-Janicka Jolanta
Published: July 2021

Background: Temporomandibular disorders (TMD) are a common reason for patients to present at dental offices. The majority of people with TMD are women between the age of 20 and 40 years. The purpose of this study was to assess the types and prevalence of temporomandibular disorders in female patients of reproductive age with menstrual disorders. Materials and methods: The study involved 65 females of reproductive age (18–40 years, an average of 28.00 ± 6.27 years). The women who qualified for the study were patients of the University Center for Maternal and Newborn’s Health hospitalized because of infertility or menstrual cycle disorders. Women with confirmed estrogen metabolism disorders participated in a clinical study with the use of Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Results: In the studied female patients with menstrual disorders, temporomandibular disorders (92.3%) were frequent occurrences. The most common type was intra-articular joint disorders (68%). Other reported complaints included masticatory muscle pain (44.62%), and degenerative joint diseases (12.3%). Conclusions: 1. In women with menstrual disorders, TMD may exist. 2. In women with TMD symptoms, their medical history should be extended to include the diagnosis of female hormone disorders.
Interventions to Support Mental Health among Those with Health Conditions That Present Risk for Severe Infection from Coronavirus Disease 2019 (COVID-19): A Scoping Review of English and Chinese-Language Literature
Authors: Davison Karen M. , Thakkar Vidhi , Lin Shen (Lamson) , Stabler Lorna , MacPhee Maura , Carroll Simon , Collins Benjamin , Rezler Zachary , Colautti Jake , Xu Chaoqun (Cherry) , Fuller-Thomson Esme , Hey Brandon , Kelly Krystal , Mullaly Laura , Remick Ron , Ravindran Arun , Paric Angela , D’Andreamatteo Carla , Smye Victoria
Published: July 2021

This study aimed to address knowledge gaps related to the prevention and management of mental health responses among those with a condition that presents risk of severe COVID-19 infection. A scoping review that mapped English and Chinese-language studies (2019–2020) located in MEDLINE (Ovid), Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo, Sociological Abstracts, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Airiti Library was undertaken. Search terms related to COVID-19, mental health, and physical health were used and articles that included all three of these factors were extracted (n = 77). With the exception of one hospital-based pilot study, there were no intervention studies targeting mental health in those at risk of severe COVID-19 infection. Promising practices such as integrated care models that appropriately screen for mental health issues, address health determinants, and include use of digital resources were highlighted. Patient navigator programs, group online medical visits, peer support, and social prescribing may also support those with complex needs. Future policies need to address digital health access inequities and the implementation of multi-integrated health and social care. Furthermore, research is needed to comprehensively assess multi-integrated interventions that are resilient to public health crises.
Effects and Responsiveness of a Multicomponent Intervention on Body Composition, Physical Fitness, and Leptin in Overweight/Obese Adolescents
Authors: Borfe Leticia , Brand Caroline , Schneiders Letícia de Borba , Mota Jorge , Cavaglieri Claudia Regina , Leite Neiva , Renner Jane Dagmar Pollo , Reuter Cézane Priscila , Gaya Anelise Reis
Published: July 2021

Physical exercise reduces the biochemical markers of obesity, but the effects of multicomponent interventions on these markers should be explored. The present study aimed to elucidate how overweight/obese adolescents respond to a multicomponent program approach on body composition, physical fitness, and inflammatory markers, using a quasi-experimental study with 33 overweight/obesity adolescents (control group (CG) = 16; intervention group (IG) = 17). The intervention consisted of 24 weeks with physical exercises and nutritional and psychological guidance. Both groups were evaluated at the pre/post-intervention moments on body mass index (BMI); body fat (%Fat); waist circumference (WC); waist/hip ratio (WHR); waist-to-height ratio (WHtR), cardiorespiratory fitness (CRF); abdominal strength, flexibility; leptin; interleukin 6; interleukin 10; and tumor necrosis factor-alpha. Mixed-analysis of variance and generalized estimation equations were used for statistical analysis. There was an interaction effect between groups and time on %Fat (p = 0.002), WC (p = 0.023), WHR (p < 0.001), WHtR (p = 0.035), CRF (p = 0.050), and leptin (p = 0.026). Adolescents were classified as 82.4% responders for %Fat, 70.6% for WC, 88.2% for WHR, and 70.6% for CRF. Further, there was an association between changes in %Fat (p = 0.033), WC (p = 0.032), and WHR (p = 0.033) between responders and non-responders with CRF in the IG. There was a positive effect on body composition, physical fitness, and leptin. In addition, reductions in body composition parameters were explained by CRF improvements.
Teachers’ Perceptions of Student Mental Health in Eastern China: A Qualitative Study
Authors: Yao Min , Kadetz Paul I , Sidibe Aissata Mahamadou , Wu Yedong , Li Jiameng , Lyu Jinping , Ma Cuiling , Hesketh Therese
Published: July 2021

In China, primary and secondary school teachers, known as ban zhu ren, have pastoral responsibility for the students in their class. The aim of this preliminary study is to identify how ban zhu ren perceive the mental health of their students, and how they have acted on these perceptions. Content analysis was used to organize the data and distinguish categories or themes derived from in-depth semi-structured interviews conducted with 27 ban zhu ren from Zhejiang and Anhui provinces. Frequencies of informant responses were used to identify the areas of agreement and disagreement across identified categories and themes among the informants. The results illustrate that the informants consider issues, such as not paying attention in class (n = 14), not getting along well with classmates (n = 12), and excessive gaming (n = 11) to be indicative of mental illness, although these would commonly be considered normal adolescent behaviors. Fifteen informants admitted that they found it difficult to work with student mental health issues, and 18 felt they had inadequate or non-existent training. However, all informants stated that they had intervened with what they perceived to be students’ mental health issues, although only 9 informants had referred students for professional help. The informants reported that they were reluctant to provide referrals, due to the stigmatization they believed students would experience if given a diagnosis of mental illness. We conclude that among our informants there is a lack of agreement on what behavioral and mental health issues are, and that informants may be confusing what are, in actuality, non-conformist or non-compliant (yet often normal), adolescent behaviors with mental illness due to insufficient mental health training.
COVID-19 Pandemic Related Research in Africa: Bibliometric Analysis of Scholarly Output, Collaborations and Scientific Leadership
Authors: Mbogning Fonkou Maxime Descartes , Bragazzi Nicola Luigi , Tsinda Emmanuel Kagning , Bouba Yagai , Mmbando Gideon Sadikiel , Kong Jude Dzevela
Published: July 2021

Scientometrics enables scholars to assess and visualize emerging research trends and hot-spots in the scientific literature from a quantitative standpoint. In the last decades, Africa has nearly doubled its absolute count of scholarly output, even though its share in global knowledge production has dramatically decreased. The still-ongoing COVID-19 pandemic has profoundly impacted the way scholarly research is conducted, published, and disseminated. However, the COVID-19-related research focus, the scientific productivity, and the research collaborative network of African researchers during the ongoing COVID-19 pandemic remain to be elucidated. This study aimed to clarify the COVID-19 research patterns among African researchers and estimate the strength of collaborations and partnerships between African researchers and scholars from the rest of the world during the COVID-19 pandemic, collecting data from electronic scholarly databases such as Web of Science (WoS), PubMed/MEDLINE and African Journals OnLine (AJOL), the largest and prominent platform of African-published scholarly journals. We found that COVID-19-related collaboration patterns varied among African regions. For instance, most of the scholarly partnerships occurred with formerly colonial countries (such as European or North-American countries). In other cases, scholarly ties of North African countries were above all with the Kingdom of Saudi Arabia. In terms of number of publications, South Africa and Egypt were among the most productive countries. Bibliometrics and, in particular, scientometrics can help scholars identify research areas of particular interest, as well as emerging topics, such as the COVID-19 pandemic. With a specific focus on the still-ongoing viral outbreak, they can assist decision- and policy-makers in allocating funding and economic-financial, logistic, organizational, and human resources, based on the specific gaps and needs of a given country or research area.
A Qualitative Exploration of Addiction Disclosure and Stigma among Faculty Members in a Canadian University Context
Authors: Burns Victoria F. , Walsh Christine A. , Smith Jacqueline
Published: July 2021

Addiction is one of the most stigmatized public health issues, which serves to silence individuals who need help. Despite emerging global interest in workplace mental health and addiction, scholarship examining addiction among university faculty members (FMs) is lacking, particularly in a Canadian context. Using a Communication Privacy Management (CPM) framework and semi-structured interviews with key informants (deans and campus mental health professionals), this qualitative study aimed to answer the following research questions: (1) What is the experience of key informants who encounter FM addiction? (2) How may addiction stigma affect FM disclosure and help-seeking? and (3) What may help reduce addiction stigma for FMs? Thematic analysis was used to identify three main themes: (1) Disclosure was rare, and most often involved alcohol; (2) Addiction stigma and non-disclosure were reported to be affected by university alcohol and productivity cultures, faculty type, and gender; (3) Reducing addiction stigma may involve peer support, vulnerable leadership (e.g., openly sharing addiction-recovery stories), and non-discriminatory protective policies. This study offers novel insights into how addiction stigma may operate for FMs in relation to university-specific norms (e.g., drinking and productivity culture), and outlines some recommendations for creating more recovery-friendly campuses.
Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois
Authors: Madrigal Jessica M. , Persky Victoria , Jackson Brian P. , Bain Amy , Siemer Matt , Pappalardo Andrea A. , Argos Maria
Published: July 2021

Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmonary function measures [forced expiratory volume in one second (FEV1; liters), forced vital capacity (FVC; liters), FEV1 to FVC ratio (FEV1:FVC), and mid-exhalation forced expiratory flow rate (FEF 25–75%; liters/second)], in a subsample of 39 children with diagnosed asthma in Chicago, Illinois. Linear regression models were used to estimate adjusted regression coefficients and standard errors (SE) for the associations between ≥ median versus <median metal exposures and natural log-transformed (ln) pulmonary function test parameters. Toenail levels of cadmium, cobalt, iron, manganese, and vanadium were higher among children residing near an industrial corridor than those in a comparison community. Copper concentrations were inversely associated with lnFEV1 (β = −0.10, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02) and lnFEF 25–75% (β = −0.25, SE = 0.09, p = 0.01); manganese concentrations were inversely associated with lnFEV1 (β = −0.11, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02), and lnFEF 25–75% (β = −0.28, SE = 0.10, p = 0.004), and vanadium concentrations were inversely associated with lnFEV1 (β = −0.08, SE = 0.04, p = 0.05) and lnFVC (β = −0.07, SE = 0.03, p = 0.03). Nickel and copper were associated with uncontrolled asthma (OR = 6.8; 95% CI 2.0, 22.8 and OR = 4.6; 95% CI 1.0, 21.0, respectively). These data suggest that selected metal exposures may be associated with impaired pulmonary function parameters and reduced asthma control among children with preexisting asthma.
“We Have to Be Strong Ourselves”: Exploring the Support Needs of Informal Carers of Aboriginal and Torres Strait Islander People with Cancer
Authors: Bell Lorraine , Anderson Kate , Girgis Afaf , Aoun Samar , Cunningham Joan , Wakefield Claire E. , Shahid Shaouli , Smith Allan Ben , Diaz Abbey , Lindsay Daniel , Masa Adam , Garvey Gail
Published: July 2021

Informal carers provide an important role in supporting people with cancer. Aboriginal and Torres Strait Islander peoples experience higher cancer mortality than other Australians. To date, very little is known about the support needs of carers of Aboriginal and Torres Strait Islander adults with cancer. This article explored these needs through a qualitative study. Twenty-two semi-structured qualitative interviews and one focus group were conducted with carers of Aboriginal and Torres Strait Islander adults with cancer (n = 12) and Aboriginal and Torres Strait Islander cancer survivors (n = 15) from Queensland, Australia. Half of the carers interviewed were Aboriginal or Torres Strait Islander Australians. Interviews were transcribed, coded and thematically analysed following an interpretive phenomenological approach. Thematic analysis of carer and survivor interviews revealed four key themes relating to carers’ needs: managing multiple responsibilities; maintaining the carer’s own health and wellbeing; accessing practical support and information; and engaging with the health system. Within these overarching themes, multiple needs were identified including specific needs relevant for carers of Aboriginal and Torres Strait Islander peoples, such as advocating for the patient; accessing Indigenous support services and health workers; and ensuring that the cultural needs of the person are recognised and respected. Identifying the needs of informal carers of Aboriginal and Torres Strait Islander cancer patients will enable greater understanding of the support that carers require and inform the development of strategies to meet these areas of need.
Family Physicians’ Perspectives on Their Role in Palliative Care: A Double Focus Group in Portugal
Authors: Cardoso Carlos Seiça , Prazeres Filipe , Xavier Beatriz , Gomes Bárbara
Published: July 2021

Background: Aggravated by the COVID-19 pandemic, the provision of palliative care for patients with palliative care needs emerges as a necessity more than ever. Most are managed in primary care by their family physicians (FP). This study aimed to understand the perspectives of specialist and trainee FPs about their role in palliative care. Methods: we conducted a double focus-group study consisting of two separate online focus-groups, one with FP specialists (n = 9) and one with FP trainees (n = 10). Results: FPs already gather two fundamental skills for the provision of palliative care: the capacity to identify patients’ needs beyond physical symptoms and the recognition that the patient belongs to a familiar, psychosocial, and even spiritual environment. They perceive their role in palliative care to be four-fold: early identification of patients with palliative care needs, initial treatment, symptom management, and patient advocacy. Participants recognized the need for palliative care training and provided suggestions for training programs. Conclusion: FPs share a holistic approach and identify multiple roles they can play in palliative care, from screening to care and advocacy. Organizational barriers must be addressed. Short training programs that combine theory, practice, and experiential learning may further the potential for FPs to contribute to palliative care.
Neither a Novel Tau Proteinopathy nor an Expansion of a Phenotype: Reappraising Clinicopathology-Based Nosology
Authors: Marsili Luca , Sharma Jennifer , Espay Alberto J. , Migazzi Alice , Abdelghany Elhusseini , Hill Emily J. , Duque Kevin R. , Hagen Matthew C. , Stephen Christopher D. , Kovacs Gabor G. , Lang Anthony E. , Hadjivassiliou Marios , Basso Manuela , Kauffman Marcelo A. , Sturchio Andrea
Published: July 2021

The gold standard for classification of neurodegenerative diseases is postmortem histopathology; however, the diagnostic odyssey of this case challenges such a clinicopathologic model. We evaluated a 60-year-old woman with a 7-year history of a progressive dystonia–ataxia syndrome with supranuclear gaze palsy, suspected to represent Niemann–Pick disease Type C. Postmortem evaluation unexpectedly demonstrated neurodegeneration with 4-repeat tau deposition in a distribution diagnostic of progressive supranuclear palsy (PSP). Whole-exome sequencing revealed a new heterozygous variant in TGM6, associated with spinocerebellar ataxia type 35 (SCA35). This novel TGM6 variant reduced transglutaminase activity in vitro, suggesting it was pathogenic. This case could be interpreted as expanding: (1) the PSP phenotype to include a spinocerebellar variant; (2) SCA35 as a tau proteinopathy; or (3) TGM6 as a novel genetic variant underlying a SCA35 phenotype with PSP pathology. None of these interpretations seem adequate. We instead hypothesize that impairment in the crosslinking of tau by the TGM6-encoded transglutaminase enzyme may compromise tau functionally and structurally, leading to its aggregation in a pattern currently classified as PSP. The lessons from this case study encourage a reassessment of our clinicopathology-based nosology.
Small Leucine-Rich Proteoglycans (SLRPs) in the Retina
Authors: Low Shermaine W. Y. , Connor Thomas B. , Kassem Iris S. , Costakos Deborah M. , Chaurasia Shyam S.
Published: July 2021

Retinal diseases such as age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual impairment worldwide. There is a critical need to understand the structural and cellular components that play a vital role in the pathophysiology of retinal diseases. One potential component is the family of structural proteins called small leucine-rich proteoglycans (SLRPs). SLRPs are crucial in many fundamental biological processes involved in the maintenance of retinal homeostasis. They are present within the extracellular matrix (ECM) of connective and vascular tissues and contribute to tissue organization and modulation of cell growth. They play a vital role in cell–matrix interactions in many upstream signaling pathways involved in fibrillogenesis and angiogenesis. In this comprehensive review, we describe the expression patterns and function of SLRPs in the retina, including Biglycan and Decorin from class I; Fibromodulin, Lumican, and a Proline/arginine-rich end leucine-rich repeat protein (PRELP) from class II; Opticin and Osteoglycin/Mimecan from class III; and Chondroadherin (CHAD), Tsukushi and Nyctalopin from class IV.
Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing
Authors: Lalami Imane , Abo Carole , Borghese Bruno , Chapron Charles , Vaiman Daniel
Published: July 2021

This review aims at better understanding the genetics of endometriosis. Endometriosis is a frequent feminine disease, affecting up to 10% of women, and characterized by pain and infertility. In the most accepted hypothesis, endometriosis is caused by the implantation of uterine tissue at ectopic abdominal places, originating from retrograde menses. Despite the obvious genetic complexity of the disease, analysis of sibs has allowed heritability estimation of endometriosis at ~50%. From 2010, large Genome Wide Association Studies (GWAS), aimed at identifying the genes and loci underlying this genetic determinism. Some of these loci were confirmed in other populations and replication studies, some new loci were also found through meta-analyses using pooled samples. For two loci on chromosomes 1 (near CCD42) and chromosome 9 (near CDKN2A), functional explanations of the SNP (Single Nucleotide Polymorphism) effects have been more thoroughly studied. While a handful of chromosome regions and genes have clearly been identified and statistically demonstrated as at-risk for the disease, only a small part of the heritability is explained (missing heritability). Some attempts of exome sequencing started to identify additional genes from families or populations, but are still scarce. The solution may reside inside a combined effort: increasing the size of the GWAS designs, better categorize the clinical forms of the disease before analyzing genome-wide polymorphisms, and generalizing exome sequencing ventures. We try here to provide a vision of what we have and what we should obtain to completely elucidate the genetics of this complex disease.