bluuebunny/crossref_metadata_2025 huggingface dataset:
CAREGIVER EMPOWERMENT AS AN EFFORT TO CREATE SEMADU ELDERLY
Authors: Indarwati Retno , Ulfiana Elida , Has Eka Misbahatul Mar'ah , Rahmadi Chandra , Mufida Laila , Yunara Yulia , Veriyallia Vera , Farhanidiah Silvia
Published: May 2023

Introduction: The world is experiencing a drastic rise in the number of elderly, both in absolute terms and as a percentage, due to the aging population. Nearly half of Indonesia's old people in 2021 suffer physical and mental health issues. The significance of the caregiver's role in helping the elderly fulfill their fundamental requirements and daily activities. This community service's goal is to offer caregivers the tools they need to raise elderly persons who are healthy, independent, and productive.
Methods: This community service is conducted through providing elderly caregivers instruction and training. 25 elderly caregivers participated in this community service. Three stages of implementation are included in this community service's activities: dementia, Activity Daily Life (ADL) with fall risk information, and creativity training.
Results: It has been found that the Sig.2-tailed value is 0.000 which means it is less than the p value <0.05, so there is a significant difference in the results of knowledge about dementia in the pretest and post-test data. The cadres looked enthusiastic in following the given training. The benefit of the training of creativity for the elderly is to train memory, prevent dementia, and keep the elderly active in old age.
Conclusion: There is a significant increase on the evaluation of knowledge about dementia Empowering health cadres can improve the quality of life and health status of the elderly. Elderly caregivers here are health cadres. Through this community service, it can become a solution and effort in dealing with the aging population in Indonesia.
Expression and function of collagens in intrahepatic cholangiocarcinoma
Authors: Colasanti Tania , Vakifahmetoglu-Norberg Helin , Mancone Carmine
Published: May 2023

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy that originates from the biliary tract located within the liver parenchyma. While the incidence rate of iCCA is increasing worldwide, the existing therapeutic options still remain limited. Thus, the spread of iCCA is the foremost cause of treatment failure representing a major clinical challenge. The aggressive nature and refractoriness of the iCCA are strictly related to the desmoplastic tumor microenvironment, in which cancer cells are surrounded by inflammatory cells, cancer-associated fibroblasts, and the aberrant deposition of members of the collagen family. In recent years, accumulating evidence revealed that remodeling of collagens is pivotal in driving the dissemination of desmoplastic cancers. In this review, we describe the expression profile of collagens and their unique architecture in iCCA and how this can dictate neoplastic cell behavior. The emerging view argues for specific strategies aimed at targeting the collagen architecture that may be useful to hamper iCCA metastasis.
Efficacy of Mindfulness Yoga on Mood and Self-compassion of Person with Mental Illness Living in a Community as a Pilot Study
Authors: Ando Michiyo , Sayoko Ito , Hiroko Kukihara
Published: May 2023

Persons with mental illness feel symptoms like depression, anxiety, or fatigue. It is important for them to decrease symptoms and increase well-being. The present study investigated efficacy of mindfulness yoga on mood and self-compassion of persons with mental illness. Participants were persons with mental illness who lived in a community. Thirteen participants received once mindfulness yoga practice for 60 hours in a welfare facility. They completed POMS 2 (Profile of Mood Scale) and Self-Compassion Scale. Anger-Hostility, Confusion-Bewilderment, Fatigue-Lethargy, Tension-Anxiety significantly decreased. Self-kindness of Self-Compassion Scale significantly increased. Impression for participating for this program were “Refreshed both mentally and physically” or “Relaxed” and so on. These results suggest that the Mindfulness Yoga may be useful to maintain mood comfortable and increase self-compassion partially of persons with mental illness living in community.
PRÁTICAS DE ORALIDADE NO ENSINO
Authors: Marques Carla
Published: May 2023

A escola segue uma longa tradição que atribui ao texto uma importância nuclear, um conceito que está presente também no tratamento didático da oralidade. Neste artigo pretende-se, no quadro da teoria de géneros do interacionismo sociodiscursivo, demonstrar que a consideração dos elementos do contexto comunicacional como dimensões ensináveis pode revelar-se de extrema importância para o aperfeiçoamento dos textos orais. Para o demonstrar, procederemos ao cotejo de textos de dois corpora, um produzido no âmbito das coordenadas da sala de aula, e outro recolhido no contexto de um concurso de oratória interescolas. A análise dos blocos textuais relativos à apresentação da posição pessoal e dos argumentos que a sustentam indica que a diversificação de objetivos comunicativos, dos papeis discursivos e dos eixos espaciotemporais poderá constituir um elemento relevante a considerar na didática da expressão oral.
O PAPEL DO GÊNERO “ENTREVISTA DE AUTOCONFRONTAÇÃO” NA FORMAÇÃO DE PROFESSORES INICIANTES
Authors: Lousada Eliane Gouvêa
Published: May 2023

Neste artigo, abordaremos um gênero oral que não se constitui como objeto de ensino, mas como instrumento, no sentido vygotskiano, para o desenvolvimento profissional: a entrevista em autoconfrontação. Embora tenha sido utilizada há mais ou menos duas décadas no campo da Formação de Professores, poucos são os trabalhos que mostram porque as características enunciativas, discursivas e linguístico-discursivas das autoconfrontações são suscetíveis de contribuir para o desenvolvimento profissional dos participantes. Partindo dessa constatação, procuraremos fazer uma síntese das características das autoconfrontações que identificamos em pesquisas anteriores para descrever alguns excertos em que há mudanças nas representações iniciais dos professores em relação a algum aspecto de seu trabalho.
ORALIDADE E FORMAÇÃO PROFISSIONAL DOCENTE
Authors: Silva Adriana Aparecida , Fonseca Carolina Alves , Vieira Daniela Silva , Oliveira Dedilene Alves de Jesus , Forte-Ferreira Elaine Cristina , Magalhães Tânia Guedes , Lima-Neto Vicente
Published: May 2023

Neste trabalho, analisamos as configurações do gênero oral prova didática em contexto de concurso para a carreira de magistério. Buscamos fundamentos acerca da importância da formação de professores fortemente relacionada ao campo do trabalho, que envolve uma série de conhecimentos e práticas profissionais. Além disso, baseamo-nos no conceito de gênero textual, a partir de diferentes perspectivas teóricas, que abarcam questões pragmáticas, históricas e ideológicas na análise, o que nos permitiu descortinar tópicos ainda frágeis em editais de concurso para tal carreira. Neste estudo exploratório, lançamos mão de seis editais de concurso, além de experiências dos autores - no papel de candidatas/os e integrantes de bancas; com esses dados, caracterizamos os tópicos mais comuns desta prática de oralidade. Os dados foram organizados em oito itens, que revelam as configurações do gênero: o contexto de circulação, os interlocutores e papéis, outros gêneros envolvidos, a simulação, as formas típicas de interação, os recursos didáticos, o conteúdo e os aspectos não linguísticos desse típico gênero oral. O estudo permite melhor visualizar elementos fundamentais para atuação do professor-candidato, o que também fortalece o discurso em prol da aprendizagem dos gêneros do métier docente na sua profissionalização.
A ORALIDADE NOS DOCUMENTOS CURRICULARES DE LÍNGUA PORTUGUESA DO ENSINO MÉDIO NO ESTADO DE PERNAMBUCO
Authors: Araújo Flávia Barbosa de Santana , Suassuna Lívia
Published: May 2023

O presente artigo é fruto da pesquisa publicada na tese intitulada “A oralidade entre o prescrito e o possível: a modalidade oral no currículo e na prática de docentes de língua portuguesa do ensino médio da rede estadual de Pernambuco”, cujo principal objetivo foi investigar como os professores de língua portuguesa da rede estadual de Pernambuco (re)elaboram e vivenciam o currículo para o ensino de oralidade. Dentre todos os objetivos específicos elencados no estudo, figurava o de analisar as orientações para o trabalho com a oralidade presentes nos documentos curriculares oficiais de língua portuguesa no âmbito estadual. Para atingir esse objetivo específico, foi realizada uma análise dos documentos curriculares oficiais da rede estadual de ensino de Pernambuco, publicados entre os anos de 2008 e 2018. A análise documental aponta que os documentos curriculares oficiais da rede estadual de Pernambuco apresentam concepções de ensino de oralidade que privilegiam usos públicos mais formais da língua falada. No entanto, pecam no tratamento das especificidades do oral, pois não sugerem uma abordagem mais sistematizada de aspectos acústicos e cinésicos, o que pode indicar uma abordagem do oral ainda voltada para uma concepção de oral como norma.
UMA ANÁLISE SEMIÓTICA DE "DESPERTAR", DE GUY DE MAUPASSANT
Authors: Terra Ernani
Published: May 2023

O artigo tem por tema a construção dos sentidos do conto “Despertar”, de Guy de Maupassant. A fundamentação teórico-metodológica é a semiótica de linha francesa, também dita discursiva ou greimasiana. O objetivo é mostrar que os sentidos que emergem da oposição semântica de base do nível fundamental se manifestam no nível discursivo por meio de temas e figuras que mostram uma personagem cindida entre dois mundos, o da realidade e o da fantasia. Na análise, destaca-se que a passagem de um mundo a outro relaciona-se a mudanças de espaço, cada um deles correspondendo a um mundo particular. Conclui-se que as coerções sociais se sobrepõem às pulsões individuais.
A Common Approach to Three Open Problems in Number Theory
Authors: Tyszka Apoloniusz
Published: May 2023

The following system of equations {x_1 \cdot x_1=x_2, x_2 \cdot x_2=x_3, 2^{2^{x_1}}=x_3, x_4 \cdot x_5=x_2, x_6 \cdot x_7=x_2} has exactly one solution in ({\mathbb N}\{0,1})^7, namely (2,4,16,2,2,2,2). Hypothesis 1 states that if a system of equations S \subseteq {x_i \cdot x_j=x_k: i,j,k \in {1,...,7}} \cup {2^{2^{x_j}}=x_k: j,k \in {1,...,7}} has at most five equations and at most finitely many solutions in ({\mathbb N}\{0,1})^7, then each such solution (x_1,...,x_7) satisfies x_1,...,x_7 \leq 16. Hypothesis 1 implies that there are infinitely many composite numbers of the form 2^{2^{n}}+1. Hypotheses 2 and 3 are of similar kind. Hypothesis 2 implies that if the equation x!+1=y^2 has at most finitely many solutions in positive integers x and y, then each such solution (x,y) belongs to the set {(4,5),(5,11),(7,71)}. Hypothesis 3 implies that if the equation x(x+1)=y! has at most finitely many solutions in positive integers x and y, then each such solution (x,y) belongs to the set {(1,2),(2,3)}. We describe semi-algorithms sem_j (j=1,2,3) that never terminate. For every j \in {1,2,3}, if Hypothesis j is true, then sem_j endlessly prints consecutive positive integers starting from 1. For every j \in {1,2,3}, if Hypothesis j is false, then sem_j prints a finite number (including zero) of consecutive positive integers starting from 1.
Coastal Wave Modeling and Forecasting with LSTM Optimization For Sustainable Energy Harvesting
Authors: Lawal Zaharaddeeen Karami , Yassin Hayati , Lai Daphne Teck Ching , Idris Azam Che
Published: May 2023

Coastal wave modeling and forecasting are essential in oceanography, sustainable marine energy, and ocean engineering. Precise forecasting of wave speed and direction are crucial for offshore operations, marine energy, risk management, environmental management, coastal and sustainable maritime management. The coastline of Brunei Darussalam can generate between 15 and 126 Giga Watt of wave energy. In this experimental research, we used two numerical approaches, the finite difference, and spectral element methods, to model and simulate wave speed and direction. We calculated the mean error between numerical and analytical solutions. We proposed a novel, promising, univariate time series forecasting model by combining the Long Short-Term (LSTM) with KerasTuner hyperparameters tuning and optimization techniques. This method helps us to improve the accuracy and efficiency of time-series forecasting.. The experimental data was computed from high-precision Acoustic Doppler Current Profiler (ADCP) sensor data. This research is part of the preliminary feasibility analysis of wave energy production in Brunei Darussalam and net zero commitment for a sustainable environment. Seven independent forecast experiments were performed for wave speed and direction in degree and radian units for 1, 3, 6, 8, 10, 12, and 24 hours. Mean squared error (MSE) was adopted as a metric for both training and testing. The experimental results reveal that the wave speed forecast has the lowest MSE compared to direction, regardless of the unit of measure, but has a longer duration. In addition, the direction forecast in the degree unit has the lowest errors compared to the unit of radians; the latter has a longer running time than the former. The model has delivered optimal results throughout the experiments with minor training and test errors. We conducted a thorough evaluations on two benchmark time series datasets, which include the study dataset and air quality index dataset, to validate the performance of the proposed model with other models. The proposed model outperforms cutting-edge forecasting models, such as the conventional LSTM, ARIMA, and Prophet. The model has the slightest forecast error compared to the existing literature’s result.
Guidelines for Prevention and the Contrast of Overweight and Obesity: State of the Art and Future Perspectives
Authors: Cancello Raffaella , Vigna Luisella , Di Maggio Antonella , Capodaglio Paolo , Bertoli Simona , Brunani Amelia
Published: May 2023

In this particular historical moment, the increase in mortality for cardiovascular disease in adults, the increase of metabolic diseases linked to overweight and obesity, it is necessary to focus the attention of medical doctors, researchers and policy makers on the promotion of correct lifestyles and prevention. The "prevention" and "cure or treatment" have long been considered distinct strategies, the almost exclusive prerogative of the public health authorities for the preventive aspects and of the clinician for the treatments. This approach has led, and still leads, to very high healthcare costs, without having a significant impact on obesity incidence. The promotion of correct lifestyles in the population and in subjects at risk in the fight against obesity/overweight, to contrast the reduction of physical activity and sedentary lifestyle, to promote the consumption of fruit and vegetables, to the reduction of the excessive consumption of salt as "Strategic lines of intervention" need to be pursued in all western countries. Actually, the preventive actions undertaken were not very effective, especially for the individuals in pediatric age. In this narrative review, based on published data, the critical points for obesity prevention will be discussed focusing on action needed during life from pre-conception to childhood, adulthood and in geriatric age to contrast obesity.
Phylogeny and Flow Cytometry of Species of the Genus Kalidium Moq. (Amaranthaceae s. lato) in Kazakhstan
Authors: Osmonali Bektemir B. , Vesselova Polina V. , Kudabayeva Gulmira M. , Skaptsov Mikhail V. , Shmakov Alexander I. , Friesen Nikolai
Published: May 2023

The article presents data on phylogeny, genome size, and ploidy of species of the genus Kalidium Moq. in the flora of Kazakhstan. Genus Kalidium belongs to the tribe Salicornieae of the subfamily Salicornioideae of the family Chenopodiaceae and unites 8 species, the main range of which covers the Iranian-Turanian and Central Asian deserts. There are 4 species in the flora of Kazakhstan: K. foliatum, K. caspicum, K. schrenkianum and the recently described K. juniperinum. Populations of species of the genus Kalidium in the saline deserts of Kazakhstan occupy large areas, often forming monodominant communities. Sometimes there is a joint growth of 2 and very rarely 3 species of the genus. During the period of fieldwork (2021-2022), populations were identified in which these species grew together with a predominance, in most cases, of K. caspicum. Samples of representatives from 15 populations were collected for research. Selected plant samples were studied by flow cytometry to determine plant ploidy. Sequencing of nrITS and two chloroplast fragments were used to build a phylogenetic tree, including sequences from the NCBI database., A phylogenetic tree of species of the genus Kalidium was compiled which considers previously published data. In the valley of the middle reaches of the Syrdarya River tetraploid populations of K. caspicum were found. A hybrid between K. foliatum and K. caspicum was found in the Ili River valley (Almaty region, Uigur district). To identify phylogenetic processes at the intraspecific level, the SCoT (Start codon targeted) fingerprinting method was used.
Development of Bio-Based Color Sensor from Myofibrillar Protein–Based Edible Film Incorporated with Sappan Wood (Caesalpinia sappan L.) Extract for Smart Food Packaging
Authors: Rostini Iis , Junianto Junianto , Warsiki Endang
Published: May 2023

The use of intelligent sensor-based packaging in food products provide quick evaluation of the quaility of the food. This study was done to develop bio-based color sensor from surimi-based color sensor incorporated with sappan wood extract (SWE) for smart food packaging. The SWE with different concentration (0.15%, 0.25%, and 0.35%) was incorporated to the myofibrillar protein-based edible film. The sappan wood-surimi edible film (SSEF) was subjected to physical properties analysis and the color changes at different pH values and soaking time at different condition were evaluated. Based on the results, different concentration of the SWE significantly (p<0.05) affected the physical properties of the film. With the increasing of pH values, the darkness, redness, and blueness of the film was increased. Based on the evaluation of the SSEF with different soaking condition, the color changes of the film in acidic condition were more stable than in neutral and alkaline condition. The results from this study showed that SSEF have the possibilities to be used as a smart food packaging possessing the capabilities to act as color sensor due to its sensitivity to the changes in pH condition of the product.
An Evolutionary Game Analysis of Shared Private Charging Piles Behavior in Low-Carbon Urban Traffic
Authors: Zhu Lequn , Zhou Ran , Li Xiaojun , Zhang Linlin
Published: May 2023

Choosing new energy vehicles for travel, especially electric vehicles, is an important component of building a low-carbon urban transportation system. However, the charging need of electric vehicle users is still constrained by the unreasonable layout and insufficient supply of public charging piles in the city. Private charging pile sharing as an alternative policy tool can play a very good role in solving this problem. But it needs decision-makers in urban transportation to take corresponding measures to promote. This paper constructs an evolutionary game model to study the decision behavior of participants in private piles sharing platform. Through numerical simulation analysis, it is found that under most parameter conditions, the government tends to establish a shared charging pile platform based on public interests. Private charging pile owners are influenced by the relationship between the cost of supply modification and revenue, and they tend to join the shared platform when they expect to recover the modification cost. The research conclusions of this paper will provide support for exploring how participants make decisions to maximize overall benefits in the development of low-carbon urban transportation.
Optimal Allocation Mechanism for Scarce Public Goods: A Cross-Country Analysis and Key Lessons from COVID-19 Vaccines
Authors: Hoang Viet
Published: May 2023

How to optimally allocate COVID-19 vaccines and scarce public goods is a crucial and sensitive question to scholars, policy-makers, and practitioners. The ethical dimensions and principles of vaccine allocation between groups are widely agreed upon, whereas the ethical dimensions and principles of vaccine distribution between countries at the peak of the COVID-19 pandemic are highly controversial. This article aims to investigate how vaccines were globally allocated across countries and propose an optimal allocation mechanism for vaccines and scarce public goods. The results show that, to a certain extent, the global allocation of COVID-19 vaccines was fair and effective. Countries with more cases and deaths obtained more vaccines and vaccinations. Wealthier countries might receive more vaccinations but also suffer more severe consequences of COVID-19. Though COVAX could miss its initial vaccine delivery targets, the facility should be considered successful in its core goals and plays a critical role in controlling the pandemic. The study proposes a fair and effective mechanism of vaccine allocation that combines the roles of markets and interventions of international organizations and national governments with three degrees: emergency, priority, and market.
Population Chemorecognition in Two Liolaemus Lizard Species: Exploring Ethological Isolation
Authors: Labra Antonieta
Published: May 2023

Reproductive isolating barriers are a crucial element in the speciation process. There are various types of barriers, and within those that act early in the speciation process, the behavioral one can play an important role in isolating populations or closely related species. It has been shown that the high diversity of some taxa correlates with the variation of sexual signals, which facilitate isolation. Here it is explored whether chemical signals may contribute to the high diversity of Liolaemus lizards, which has more than 290 species. Population chemical discrimination was investigated in two co-distributed species, L. tenuis and L. lemniscatus. The studied populations were closely located and likely belonged to the same genetic lineages. Lizards of both species discriminated between scents of their own and different populations, and in most cases, scents from their population were preferred. Results suggest a fast evolution of scents, and their recognition, and there for the ethological barriers associated with the chemical modality may evolve fast. However, because the studied species differed in the strength of the exhibited population chemical discrimination, ethological barriers evolve at different rates across species. It can be concluded that ethological barriers involving the chemical modality may disrupt species' cohesion, contributing to Liolaemus diversification, in synergy or not with geographical barriers.
Design of Bifunctional Nanocatalysts for Biomass Processing
Authors: Matveeva Valentina G. , Bronstein Lyudmila M.
Published: May 2023

Bifunctional catalysts consisting of mono- or bimetallic nanoparticles (NPs) and zeolite supports received considerable attention due to excellent catalytic properties in numerous reactions including direct and indirect biomass processing. Here, we discuss major approaches to the preparation of NPs in zeolites, concentrating on methods allowing the best interplay (synergy) between metal and acid sites which is normally achieved for small NPs well-distributed through zeolite. We focus on modification of zeolites to provide structural integrity and controlled acidity which can be accomplished by incorporation of certain metal ions or elements. The other modification avenue is the adjustment of the zeolite morphology including creation of numerous defects for the NP entrapment and designed porosity. In this review we also provide examples of synergy between metal and acid sites and emphasize that without density functional theory calculations many assumptions about interactions between active sites stay unvalidated. Finally, we describe the most interesting examples of direct and indirect biomass (waste) processing for the last five years.
The Ability to Predict Death in Patients with Acute PE
Authors: Chijik Alexander , Zerdev Michael , Daud Wadie Abu , Sela Yaron , Blum Arnon
Published: May 2023

Background: Pulmonary emboli (PE) is a life threatening condition that is discovered in many patients only "post mortem". Adequate and timely detection of PE is crucial, because of the high mortality and morbidity and the sudden unexpected hemodynamic collapse that may occur in patients with PE.

Objectives: To assess the ability to predict clinical outcome of patients with acute PE, using a non-gated computed tomography pulmonary angiography (CTPA), based on the dimensions of the right ventricle.

Methods: A retrospective study that analyzed CTPA images of patients admitted with acute PE during the years 2012-2017 in Baruch Padeh Medical Center. The cohort study included 300 patients with documented acute PE, among them 255 were hospitalized in medical (non-intensive care unit) wards, and 45 were patients were hospitalized in an intensive care unit (ICU).

Results: Among the 45 patients admitted to the ICU, 8% died. Larger RV diameters predicted mortality (OR=10.14, 95% CI [1.09-93.86]) as well as lower systolic and diastolic blood pressure measurements (p=0.001 and 0.01).

Among the 255 patients that were admitted in the Internal Medicine Ward 7% died. Older age (p=0.028), sepsis and cancer (both p<0.001), high WBCs count (p<0.001), and renal failure (p<0.001) predicted death.

Overall, of all 300 patients that were admitted, lower blood pressure (systolic and diastolic) (p<0.001, 0.008), older age (p<0.007), sepsis (p<0.001), cancer (p=0.006), higher WBCs count (p<0.001), and impaired renal function (p<0.001) predicted death among patients admitted with confirmed acute PE.

Conclusions: Clinical parameters and hematological parameters could predict the outcome of patients admitted with acute PE. RV diameter, measured by the non-ECG gated CTPA had an additive predictive value for patients who were hemodynamically unstable on admission and were hospitalized in the ICU.
The Renin-Angiotensin-System in COVID-19: Can Long COVID Be Predicted?
Authors: König Simone , Vollenberg Richard , Tepasse Phil-Robin
Published: May 2023

(1) Background: Co-morbidities such as hypertension and cardiovascular disease are major risk factors for severe COVID-19. The renin-angiotensin-system (RAS) is critically involved in their pathophysiology and is counterbalanced by both angiotensin-converting enzyme 2 (ACE2), the functional receptor of SARS-CoV-2, and the kallikrein-kinin-system (KKS). Considerable research interest with respect to COVID-19 treatment is, thus, currently directed towards the components of these systems. In an earlier study, we noticed significantly reduced carboxypeptidase N (CPN, KKS member) activity and partially excessive angiotensin-converting enzyme (ACE, RAS member) activity in the sera of both hospitalized (HoP) COVID-19 patients and a sub-group of covalescent patients, while in the majority of the probands recovering from the disease these values had returned to normal. The data had been obtained using bradykinin (BK) as a reporter peptide, which is a target of both CPN and ACE, and they were supplemented by serum proteomics of the same patient cohort. We hypothesized that the data could be indicative of Long COVID, which had not been fully appreciated at the time of our study.; (2) Methods: The data were re-evaluated in the light of Long COVID. The recent literature on the RAS in COVID-19, antihypertensiva, and Long COVID was briefly reviewed.; (3) Results: While the levels of the BK serum degradation products should return to normal concentrations during convalescence, this was not true for some patients. This could be due to persisting liver problems, because CPN is synthesized there, but also to a dysregulated RAS. This was not reflected in the levels of selected RAS/KKS serum proteins like angiotensinogen (AGT), although AGT correlated with disease severity in HoP. However, standard tests in routine patient care in Long COVID often come back normal, and it may be that BK degradation is specific in some pathophysiologies. Moreover, the HoP group was sub-divided based on the serum protein profiles and COVID-19 severity.; (4) Conclusions: We point out two insights: 1) Sensitive technology such as omics methods might provide unexpected significant differences within the pre-defined patient groups of a clinical study. Those can only be explored, if the cohorts are large enough and properly matched with respect to the parameters known beforehand (e.g., age, gender, co-morbidities). 2) Results of the BK-reporter serum protease activity assay could be indicative of persisting liver problems and/or potentially of Long COVID. Clinical studies are required to test this hypothesis.
3EE, 20Ac-Ingenol Decreases HIF-1?/PD-L1 through ATR Activation under Hypoxia and Induces Apoptosis in Panc-1 Cells Accumulating Cyclin D1
Authors: Miyata Shohei , Ishii Takashi , Kitanaka Susumu
Published: May 2023

Apoptosis under severe hypoxia is induced through p53 phosphorylation and HIF-1?-dependent p53 accumulation via ATR activation by DNA damage response (DDR) activation through replication stress. We previously demonstrated that the topoisomerase I catalytic inhibitor, 3EZ, 20Ac-ingenol, specifically induced apoptosis in Jeko-1 and Panc-1 cells, both of which are cell lines that show cyclin D1 overexpression. After progression to the S phase facilitated by nuclear cyclin D1, in the presence of 3EZ, 20Ac-ingenol, an intra S phase checkpoint was induced in ATR activation as part of replication stress-induced DDR. In this study, we examined whether 3EE, 20Ac-ingenol induces a higher degree of p53 phosphorylation and additional HIF-1? and p53 accumulation in response to replication stress-induced DDR activation under the hypoxic condition than under the normoxic condition by controlling ATR activation. 3EE, 20Ac-ingenol induced p53 activation and HIF-1?-dependent p53 accumulation through cooperative ATR activation via induced DDR with the hypoxia in Panc-1 cells. The Jeko-1 cells showed slight HIF-1? accumulation under hypoxia, but this was not decreased by 3EE, 20Ac-ingenol, so that the cells remained resistant to hypoxia. 3EE, 20Ac-ingenol induces an intricate interplay between p53 and HIF-1? accumulation via ATR activations that results in high p53 accumulation, which advanced transient expression and early disappearance of HIF-1?. The strong p53 accumulation and consequent PTEN activation also decreased HIF-1? accumulation and PD-L1 expression, which resulted in intense apoptosis.
Experimental Investigation of Polymer Reinjection in Long Conduits for Material Sustainability and Cost Reduction of Enhanced Oil Recovery
Authors: Fakher Sherif , Khlaifat Abdelaziz Lafi
Published: May 2023

Polymers are one of the most widely used chemicals in the oil and gas industry. They are used for mobility control in enhanced oil recovery, in conformance control as a crosslinked plugging agent, as a fracking fluid for fracture propagation and proppant transportation, and in drilling fluids as an additive for drilling mud enhancement. In the majority of its applications in the petroleum industry, the polymer needs to be injected under high pressures and temperatures. This can impact the polymer structure significantly and compromises the possibility of reusing the injected polymer for cost reduction and material sustainability. This research characterizes the polymer injectivity in different pore sizes under different conditions and evaluates the polymer conditions after injection. Based on this, the ability to reinject the polymer in the porous media is discussed. The factors studied include the pore size, the polymer concentration, the polymer injection flowrate, and polymer injectivity. Results showed that the polymer usually undergoes four main degradations during injection including dehydration, syneresis, shearing, and excessive hydrolysis. The experimental results showed that one or more of the polymer degradations resulted in the inability to reinject the polymer in most cases.
Molecular Networks of Platinum Drugs and Arsenic Trioxide and Its Interaction With microRNAs in Cancer
Authors: Tanabe Shihori , Boonstra Eger , Hong Taehun , Quader Sabina , Ono Ryuichi , Cabral Horacio , Aoyagi Kazuhiko , Yokozaki Hiroshi , Sasaki Hiroki
Published: May 2023

To reveal the relationship between metallodrugs and cancer malignancy, molecular networks of anti-cancer drugs were analyzed. Molecular networks in several types of cancers were analyzed in Ingenuity Pathway Analysis (IPA). Analysis of carboplatin revealed the causal network in diffuse large B-cell lymphoma. Analysis of 12 analyses of cisplatin treatment identified causal networks including camptothecin and NUPR1. The causal network of camptothecin, which includes PTEN, FAS, and IRF1, was inactivated in diffuse-type GC and activated in intestinal-type GC. Upstream regulator analysis of cisplatin revealed an increase in FAS, BTG2, SESN1 and CDKN1A, and the involvement of the tumor microenvironment pathway. Upstream regulators of cisplatin-treated lung adenocarcinoma included a histone deacetylase inhibitor, trichostatin A (TSA). Causal network of arsenic was inactivated in diffuse-type GC and activated in intestinal-type GC, and included ERK, EGFR, SRC, IKK and TP53. Prediction of RNA-RNA interactions with the causal network of arsenic identified 10 microRNAs including mir-101, mir-103, and mir-22. The results revealed the involvement of EMT in arsenic treatment. Analysis of oxaliplatin, a platinum drug, revealed that the SPINK1 pancreatic cancer pathway is inactivated in ischemic cardiomyopathy. The study showed the importance of the relationship between platinum drugs or arsenic trioxide and the tumor microenvironment in the treatment of resistant cancer in humans.
Research on Performance Zoning of Asphalt Pavement in Xinjiang and Performance Grade(PG) of Asphalt Binder in Karamay
Authors: Dong Chaofei , Feng Liqun , Xu Yafeng
Published: May 2023

Asphalt binder is a temperature sensitive material, whose performance is greatly affected by the climate change of the environment. Improper selection of asphalt will cause a lot of damage and affect the durability of the road. The establishment of asphalt pavement performance zoning in Xinjiang, a vast area with great temperature difference, will provide reference for the selection of asphalt suitability, the refinement of pavement design and the sustainable development of road engineering. In this study, 11 years of temperature data in Xinjiang region were collected and analyzed, and 98% reliability of pavement design temperature was used to draw a performance grading map of asphalt pavement in Xinjiang region based on ArcGIS platform. Finally, Xinjiang region was divided into 9 performance zones. At the same time, the performance grade (PG) of five kinds of asphalt binders in Karamay were explored. The result shows that there is little difference in continuous PG span between different matrix asphalt binders, the lower penetration grade, the better high temperature performance, the worse low temperature performance. After adding SBS modifier, the continuous PG span can be higher than the matrix asphalt in 20 ℃. All these provide the basis for reasonable selection of asphalt binders in different areas of Xinjiang.
Management of Antracnosis with Electrochemically Activated Salt Solutions (EASS) on Bean Culture
Authors: Marquez-Blanco María Guadalupe , Meas-Vong Yunny , Z. Guerrero-Aguilar Brenda , Rivero-Montejo Samantha de J. , Contreras-Medina Luis Miguel , Torres-Pacheco Irineo , Guevara-González Ramón Gerardo , González-Chavira Mario Martin , Ortega Adrian Esteban
Published: May 2023

Common bean (Phaseolus vulgaris L.) is an important crop for food security and for national economics for several countries worlwide. One of the most important factors of risk in common bean production is the fungal disease anthracnose caused by Colletotrichum lindemuthianum, which in some cases, causes complete yield losses; this kind of plant disease is usually managed through the application of chemical products such as fungicides, that are commonly not accepted by society, this rejection is based on the relationship of pesticides with health damage and environmental contamination. In order to help in solving this drawbacks, the present work propose the use of Electrochemically Activated Salt Solutions(EASS) as a safer pathogen control agent in crops due to it have shown an elicitor and biostimulant effect on plants such as tobacco and apple. With this background, this manuscript presented in vitro results of the evaluation of the inhibitory effect for multiple bean pathogens and in vivo results of EASS in the common bean-Colletotrichum pathosystem by in vitro evaluations of the inhibitory effect for multiple bean pathogens and in vivo evaluation of the infection severity and defense activation such as secondary metabolites production and antioxidant activity. EASS presence in growth media had strong inhibitory effect, at beginning of experiment, for some of the evaluated fungi. EASS showed effect against the development of the disease when applied in specific doses to prevent distress in plants.
Sustainable Alternatives for the Development of Thermoset Composites with Low Environmental Impact
Authors: Ares-Elejoste Patricia , Iturmendi Aitziber , Seoane-Rivero Ruben , Gondra Koldo
Published: May 2023

The current concerns of both society and materials industries about the environmental impact of thermoset composites, as well as new legislation, have led the scientific sector to search for more sustainable alternatives to reduce the environmental impact of thermoset composites. Until now, to a large extent, sustainable reinforcements have been used to manufacture more sustainable composites and thus contribute to the reduction of pollutants. However, in recent years, new alternatives have been developed such as thermosetting resins with bio-based content and/or systems such as recyclable amines and vitrimers that enable recycling/reuse. Throughout this review, some new bio-based thermoset systems as well as new recyclable systems and sustainable reinforcements are described and a brief overview of the biocomposites market and its impact is shown.
Biomass Derived N-doped Porous Carbon Made from Reed Straw for Enhanced Supercapacitor
Authors: Liao Yuyi , Shang Zhongtao , Ju Guangrui , Wang Dingke , Yang Qiao , Wang Yuan , Yuan Shaojun
Published: May 2023

Developing advanced carbon materials by utilizing biomass waste has attracted much attention. Herein, a N-doped carbon material (RSM-0.33-550) was prepared by directly pyrolyzing reed straw and melamine. The as-prepared RSM-0.33-550 possessed a N content of 6.02% and a specific surface area of 547.1 m2 g-1. As the anode for supercapacitors (SCs), in 6 M KOH, such RSM-0.33-550 exhibited a capacitance of 202.8 F g-1 at a current density of 1 A g-1. At a high current density of 20 A g-1, it still remained a capacitance of 158 F g-1. Notably, it delivered an excellent stability with capacity retention of 96.3% at 20 A g-1 after 5000 cycles. This work not only offer a new electrode material for SCs, but also gives a new insight for rationally utilizing the biomass waste for energy storage.
Adhesive and Flame-Retardant Properties of Starch/Ca2+ Gels with Different Amylose Contents
Authors: Liu Peng , Ling Jiandi , Mao Taoyan , Liu Feng , Zhou Wenzhi , Zhang Guojie , Xie Fengwei
Published: May 2023

Starch being renewable and biodegradable is a viable resource for developing sustainable and environmentally friendly materials. This work explores the potential of starch/Ca2+ gels based on waxy corn starch (WCS), normal corn starch (NCS), and two high-amylose corn starches, G50 (55% amylose content) and G70 (68% amylose content) as flame-retardant adhesives. Being stored at 57% relative humidity for up to 30 days, the G50/Ca2+ and G70/Ca2+ gels are stable without water absorption or retrogradation. The starch gels with increasing amylose content displayed increased cohesion, as reflected by significantly higher tensile strength and fracture energy. All the four starch-based gels show good adhesive properties on corrugated paper. For wooden boards, because of the slow diffusion of the gels, the adhesive abilities are weak initially but improve with storage extension. After storage, the adhesive abilities of the starch-based gels are almost the same except for G70/Ca2+, which is peeled off from the wood surface by itself. Moreover, all the starch/Ca2+ gels exhibit excellent flame retardancy with limiting oxygen index (LOI) values all around 60. This work demonstrates a facile method to prepare starch-based flame-retardant adhesives simply by gelating starch with a CaCl2 solution, which can be used in paper or wood products.
Job Crafting and Work-Life Balance in a Mature Organization
Authors: Kardas Jarosław Stanisław
Published: May 2023

The study is focused on identifying areas of individualization in those mature organizations in which employees are free to make changes. In addition, factors affecting work-life balance and overlap between the jobs employees do and would like to do are determined. A critical review of the literature and a diagnostic survey, including interviews, questionnaires and observations, were used in the research process, together with the analysis of data concerning working conditions. Employees' opinions (n=300) on individualization areas, job crafting and overlap between performed and preferred jobs were analyzed. Calculations were done using IBM SPSS. According to the results, the maintenance of work-life balance (WLB) and the implementation of job crafting positively affect employee efficiency, counteracting professional burnout and a decrease in motivation. It turns out that employees of mature organizations are familiar with the areas of individualization and in some cases have freedom to implement job crafting. They like the work they do, which translates into well-maintained work-life balance. However, a big challenge for mature organizations is the constantly changing economic environment, the long-term nature of work-life balance programmes and their deferred effects. The results of the research can be an important starting point for extended studies.
Deep Image Analysis Methods for Microalgae Identification
Authors: Soar Jeffrey , Lih Oh Shu , Hui Wen Loh , Ward Aletha , Sharma Ekta , Deo Ravinesh , Barua Prabal Datta , Tan Ru-San , Rinen Eliezer , Acharya U Rajendra
Published: May 2023

Plant-based protein sources derived from microalgae offer promise as low-carbon emission and nutrient-dense sources for human consumption. The current management of microalgae cultivation relies heavily on manual microscopic examination in order to identify desired and competing species, as well as predators. In this study, we trained and tested a transfer learning model modified from EfficientNetV2 B3 on 434 and 161 prospectively acquired images of the preferred Nannochloropsis sp microalgae and competitor Spirulina, respectively, and achieved >98% classification for both species on tenfold cross-validation. The model was further enhanced with gradient-weighted class activation mapping, which allowed visualization of regions of the input images that were relevant to the classification, thereby improving its explainability. In this paper, we demonstrate that a simple deep transfer learning model can be used to identify microalgae species. The application addresses the practical need for robust automated monitoring of microalgae populations on industrial microalgae farms.
Ecological Factors Driving Tree Diversity across Spatial Scales in Temperate Forests, Northeast China
Authors: Gu Yue , Zhang Junhui , Ma Wang , Feng Yue , Yang Leilei , Li Zhuo , Guo Yanshuang , Shi Guoqiang , Han Shijie
Published: May 2023

Species diversity has been shown to be influenced by environmental factors, but the mechanism underlying their relationship remains unclear across spatial scales. Based on field investigation data collected from 3,077 sample plots in temperate forest ecosystems, we compared tree species richness, evenness and dominance at 10 km × 10 km, 30 km × 30 km and 90 km × 90 km spatial scales. Then, we detected the scale dependence of changes in tree species composition on climate, topography and forest structure using variation partitioning and quantified their contribution to tree diversity with gradient boosted models (GBMs) and fitted their relationships. The magnitude of tree richness, evenness and dominance significantly increased with spatial scale. Ecological factors jointly accounted for 24.3%, 26.5% and 38.5% of the variation in tree species composition at the three spatial scales, respectively. Annual mean temperature had a strong impact on tree richness, evenness and dominance and peaked at an intermediate scale. Tree evenness and dominance increased with the variation of temperature but had upper and lower limits. Tree richness obviously increased with annual precipitation on multiple scales and decreased with annual sunshine duration at large spatial scale. Tree richness, evenness and dominance obviously increased with the variation elevation and diameter at breast height at large scales and small scales, respectively. Tree dominance decreased with tree height in a hump at small scale. The dependence of tree diversity on ecological factors increased with spatial scales. Furthermore, different factors exert various controls on tree diversity at different spatial scales, representing a comprehensive mechanism regulating tree diversity.
Agile Methodology for the Standardization of Engineering Requirements using Large Language Models
Authors: Tikayat Ray Archana , Cole Bjorn F , Pinon Fischer Olivia J , Bhat Anirudh Prabhakara , White Ryan T , Mavris Dimitri N
Published: May 2023

The increased complexity of modern systems is calling for an integrated and comprehensive approach to system design and development and in particular, a shift towards Model-Based Systems Engineering (MBSE) approaches for system design. The requirements that serve as the foundation for these intricate systems are still primarily expressed in Natural Language (NL), which can contain ambiguities and inconsistencies that hinder their direct translation into models. The colossal developments in the field of Natural Language Processing (NLP) in general and Large Language Models (LLMs) in particular can serve as an enabler for the conversion of NL requirements into semi-machine-readable requirements. This is expected to facilitate their standardization and use in a model-based environment. This paper discusses a two-fold strategy for converting NL requirements into semi-machine-readable requirements using language models. The first approach involves creating a requirements table by extracting information from free-form NL requirements. The second approach is an agile methodology that facilitates the identification of boilerplate templates for different types of requirements based on observed linguistic patterns. For this study, three different LLMs were utilized. Two of these models were fine-tuned versions of Bidirectional Encoder Representations from Transformers (BERT), specifically aeroBERT-NER and aeroBERT-Classifier, which were trained on annotated aerospace corpora. Another LLM, called flair/chunk-english, was utilized to identify sentence chunks present in NL requirements. All three language models were utilized together to achieve the standardization of requirements. To demonstrate the effectiveness of the methodologies, requirements from Parts 23 and 25 of Title 14 Code of Federal Regulations (CFRs) were employed, and a total of two, five, and three boilerplate templates were identified for design, functional, and performance requirements, respectively.