bluuebunny/crossref_metadata_2025 huggingface dataset:
A Precise Method to Evaluate 360 Degree Measures of Optic Cup and Disc Morphology in an African American Cohort and Its Genetic Applications
Authors: Addis Victoria , Chen Min , Zorger Richard , Salowe Rebecca , Daniel Ebenezer , Lee Roy , Pistilli Maxwell , Gao Jinpeng , Maguire Maureen G. , Chan Lilian , Gudiseva Harini V. , Zenebe-Gete Selam , Merriam Sayaka , Smith Eli J. , Martin Revell , Parker Ostroff Candace , Gee James C. , Cui Qi N. , Miller-Ellis Eydie , O’Brien Joan M. , Sankar Prithvi S.
Published: December 2021

(1) Background: Vertical cup-to-disc ratio (CDR) is an important measure for evaluating damage to the optic nerve head (ONH) in glaucoma patients. However, this measure often does not fully capture the irregular cupping observed in glaucomatous nerves. We developed and evaluated a method to measure cup-to-disc ratio (CDR) at all 360 degrees of the ONH. (2) Methods: Non-physician graders from the Scheie Reading Center outlined the cup and disc on digital stereo color disc images from African American patients enrolled in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. After converting the resultant coordinates into polar representation, the CDR at each 360-degree location of the ONH was obtained. We compared grader VCDR values with clinical VCDR values, using Spearman correlation analysis, and validated significant genetic associations with clinical VCDR, using grader VCDR values. (3) Results: Graders delineated outlines of the cup contour and disc boundaries twice in each of 1815 stereo disc images. For both cases and controls, the mean CDR was highest at the horizontal bisector, particularly in the temporal region, as compared to other degree locations. There was a good correlation between grader CDR at the vertical bisector and clinical VCDR (Spearman Correlation OD: r = 0.78 [95% CI: 0.76–0.79]). An SNP in the MPDZ gene, associated with clinical VCDR in a prior genome-wide association study, showed a significant association with grader VCDR (p = 0.01) and grader CDR area ratio (p = 0.02). (4) Conclusions: The CDR of both glaucomatous and non-glaucomatous eyes varies by degree location, with the highest measurements in the temporal region of the eye. This method can be useful for capturing innate eccentric ONH morphology, tracking disease progression, and identifying genetic associations.
Circulating Transcriptional Profile Modulation in Response to Metabolic Unbalance Due to Long-Term Exercise in Equine Athletes: A Pilot Study
Authors: Cappelli Katia , Mecocci Samanta , Capomaccio Stefano , Beccati Francesca , Palumbo Andrea Rosario , Tognoloni Alessia , Pepe Marco , Chiaradia Elisabetta
Published: December 2021

Physical exercise has been associated with the modulation of micro RNAs (miRNAs), actively released in body fluids and recognized as accurate biomarkers. The aim of this study was to measure serum miRNA profiles in 18 horses taking part in endurance competitions, which represents a good model to test metabolic responses to moderate intensity prolonged efforts. Serum levels of miRNAs of eight horses that were eliminated due to metabolic unbalance (Non Performer-NP) were compared to those of 10 horses that finished an endurance competition in excellent metabolic condition (Performer-P). Circulating miRNA (ci-miRNA) profiles in serum were analyzed through sequencing, and differential gene expression analysis was assessed comparing NP versus P groups. Target and pathway analysis revealed the up regulation of a set of miRNAs (of mir-211 mir-451, mir-106b, mir-15b, mir-101-1, mir-18a, mir-20a) involved in the modulation of myogenesis, cardiac and skeletal muscle remodeling, angiogenesis, ventricular contractility, and in the regulation of gene expression. Our preliminary data open new scenarios in the definition of metabolic adaptations to the establishment of efficient training programs and the validation of athletes’ elimination from competitions.
Transcription Factor 21 Promotes Chicken Adipocyte Differentiation at Least in Part via Activating MAPK/JNK Signaling
Authors: Zhang Xinyang , Cheng Bohan , Jiang Haixu , Liu Chang , Cao Zhiping , Luan Peng , Wang Ning , Li Hui
Published: December 2021

The molecular mechanisms of transcription factor 21 (TCF21) in regulating chicken adipogenesis remain unclear. Thus, the current study was designed to investigate the signaling pathway mediating the effect of TCF21 on chicken adipogenesis. Immortalized chicken preadipocytes cell line (ICP), a preadipocyte cell line stably overexpressing TCF21 (LV-TCF21) and a control preadipocyte cell line (LV-control) were used in the current study. We found that the phosphorylation of c-Jun N-terminal kinases (JNK) was significantly elevated in LV-TCF21 compared to LV-control. After treating ICP cells with a JNK inhibitor SP600125, the differentiation of ICP was inhibited, as evidenced by decreased accumulation of lipid droplets and reduced expression of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein α (C/EBPα), adipocyte fatty acid binding protein (A-FABP), and lipoprotein lipase (LPL). Moreover, we found that the inhibition of JNK by SP600125 remarkably impaired the ability of TCF21 to drive adipogenesis. Taken together, our results suggest that TCF21 promotes the differentiation of adipocytes at least in part via activating MAPK/JNK pathway.
Comparison of Petrophysical Properties of Porous Rocks Using NMR, Micro-CT, and Fluid Flow Simulations
Authors: Jyoti Apoorv , Haese Ralf R.
Published: December 2021

Micro-computed tomography (micro-CT) is increasingly utilized to image the pore network and to derive petrophysical properties in combination with modelling software. The effect of micro-CT image resolution and size on the accuracy of the derived petrophysical properties is addressed in this study using a relatively homogenous sandstone and a heterogenous, highly porous bioclastic limestone. Standard laboratory procedures including NMR (nuclear magnetic resonance) analysis, micro-CT analysis at different image resolutions and sizes and pore-scale flow simulations were used to determine and compare petrophysical properties. NMR-derived pore-size distribution (PSD) was comparable to the micro-CT-derived PSD at a resolution of 7 µm for both the rock types. Porosity was higher using the water saturation method as compared to the NMR method in both rocks. The resolution did not show a significant effect on the porosity of the homogeneous sandstone, but porosity in the heterogeneous limestone varies depending on the location of the sub-sample. The transport regime in the sandstone was derived by simulations and changed with the resolution of the micro-CT image. The transport regime in the sandstone was advection-dominated at higher image resolution and diffusion-dominated when using a lower image resolution. In contrast, advection was the dominant transport regime for the limestone based on simulations using higher and lower image resolutions. Simulation-derived permeability for a 400 Voxel3 image at 7 µm resolution in the Berea sandstone matched laboratory results, although local heterogeneity within the rock plays an integral role in the permeability estimation within the sub-sampled images. The simulation-derived permeability was highly variable in the Mount Gambier limestone depending on the image size and resolution with the closest value to a laboratory result simulated with an image resolution of 2.5 µm and a size of 300 Voxel3. Overall, the study demonstrates the need to decide on micro-CT parameters depending on the type of petrophysical property of interest and the degree of heterogeneity within the rock types.
Soultz-sous-Forêts Geothermal Reservoir: Structural Model Update and Thermo-Hydraulic Numerical Simulations Based on Three Years of Operation Data
Authors: Baujard Clément , Rolin Pauline , Dalmais Éléonore , Hehn Régis , Genter Albert
Published: December 2021

The geothermal powerplant of Soultz-sous-Forêts (France) is investigating the possibility of producing more energy with the same infrastructure by reinjecting the geothermal fluid at lower temperatures. Indeed, during the operation of the powerplant, the geothermal fluid is currently reinjected at 60–70 °C in a deep fractured granite reservoir, and the MEET project aims to test its reinjection at 40 °C. A 3D hydrothermal study was performed in order to evaluate the spreading of the thermal front during colder reinjection and its impact on the production temperature. In the first step, a 3D structural model at fault scale was created, integrating pre-existing models from 2D vintage seismic profiles, vertical seismic profiles, seismic cloud structure and borehole image logs calibrated with well data. This geometrical model was then adapted to be able to run hydrothermal simulation. In the third step, a 3D hydrothermal model was built based on the structural model. After calibration, the effect of colder reinjection on the production temperature was calculated. The results show that a decrease of 10 °C in the injection temperature leads to a drop in the production temperature of 2 °C after 2 years, reaching 3 °C after 25 years of operation. Lastly, the accuracy of the structural model on which the simulations are based is discussed and an update of the structural model is proposed in order to better reproduce the observations.
Investigating the Potential Role of Geological Context on Groundwater Quality: A Case Study of the Grenville and St. Lawrence Platform Geological Provinces in Quebec, Canada
Authors: Tremblay Roxane , Walter Julien , Chesnaux Romain , Boumaiza Lamine
Published: December 2021

The hydrogeochemical study of the Lanaudière and Eastern Mauricie regions (Canada) demonstrates that trace elements appear to be better tracers of geological influence on groundwater chemistry than major elements. Isotopic ratios and the similar chemical composition of groundwater suggest that the physicochemical parameters of groundwater have a greater effect on hydrogeochemical mechanisms than the immediate geological environment The results allow us to propose a conceptual model of groundwater geochemical evolution with the aim to guide the protection and sustainable management of regional groundwater resources in the Lanaudière and Eastern Mauricie regions. These regions were selected because of their location at the boundary of the Grenville and St. Lawrence Platform geological provinces, representing two distinct geological contexts (Precambrian crystalline rocks and Paleozoic sedimentary rocks). Regional-scale hydrogeochemical and isotopic groundwater characterization was carried out to identify the role of the differences in regional geology on groundwater quality. Our analyses included major and trace elements, stable isotopes, and multivariate statistics. Similar processes are at the origin of dissolved major chemical elements and suggest that soluble minerals common to both geological provinces control groundwater chemistry. If differences exist, they are due to the hydrogeological conditions of the samples, such as residence time or groundwater entrapment at the time of the postglacial marine incursion of the Champlain Sea, rather than the geological context. Some differences, sometimes significant, were observed for some minor elements (F−, Mn2+, H2S), which implies a more comprehensive knowledge of the chemistry of the stratigraphic units within the Lanaudière and Eastern Mauricie aquifers.
Will Mass Spectrometry Replace Current Techniques for Both Routine Monitoring and MRD Detection in Multiple Myeloma?
Authors: Thoren Katie L.
Published: December 2021

In recent years, mass spectrometry has been increasingly used for the detection of monoclonal proteins in serum. Mass spectrometry is more analytically sensitive than serum protein electrophoresis and immunofixation, can help distinguish therapeutic monoclonal antibodies from M-proteins, and can detect the presence of post-translational modifications. Mass spectrometry also shows promise as a less-invasive, peripheral-blood-based test for detecting minimal residual disease in multiple myeloma. Studies comparing the clinical utility of mass spectrometry to current blood- and bone-marrow-based techniques have been conducted. Although still primarily limited to research settings, clinical laboratories are starting to adopt this technique for patient care. This review will discuss the current status of mass spectrometry testing for multiple myeloma, the benefits and challenges of this technique, and how it may be incorporated into clinical practice in the future.
Field Trial of an Automated Batch Chlorinator System at Two Shared Shallow Tubewells among Camps for Forcibly Displaced Myanmar Nationals (FDMN) in Cox’s Bazar, Bangladesh
Authors: Amin Nuhu , Rahman Mahbubur , Alam Mahbub-Ul , Shoab Abul Kasham , Alome Md. Kawsar , Amin Maksudul , Huda Tarique Md. Nurul , Unicomb Leanne
Published: December 2021

Chlorination of shallow tubewell water is challenging due to various iron concentrations. A mixed-method, small-scale before-and-after field trial assessed the accuracy and consistency of an automated chlorinator, Zimba, in Rohingya camp housing, Cox’s Bazar. From August–September 2018, two shallow tubewells (iron concentration = 6.5 mg/L and 1.5 mg/L) were selected and 20 households were randomly enrolled to participate in household surveys and water testing. The field-team tested pre-and post-treated tubewell and household stored water for iron, free and total chlorine, and E. coli. A sub-set of households (n = 10) also received safe storage containers (5 L jerry cans). Overall mean iron concentrations were 5.8 mg/L in Zimba water, 1.9 mg/L in household storage containers, and 2.8 mg/L in the project-provided safe storage containers. At baseline, 0% samples at source and 60% samples stored in household vessels were contaminated with E. coli (mean log10 = 0.62 MPN/100 mL). After treatment, all water samples collected from source and project-provided safe storage containers were free from E. coli, but 41% of post-treated water stored in the household was contaminated with E. coli. E. coli concentrations were significantly lower in the project-provided safe storage containers (log10 mean difference = 0.92 MPN, 95% CI = 0.59–1.14) compared with baseline and post-treated water stored in household vessels (difference = 0.57 MPN, 95% CI = 0.32–0.83). Zimba is a potential water treatment technology for groundwater extracted through tubewells with different iron concentrations in humanitarian settings.
Exploring Tobacco and E-Cigarette Use among Queer Adults during the Early Days of the COVID-19 Pandemic
Authors: Valera Pamela , Owens Madelyn , Malarkey Sarah , Acuna Nicholas
Published: December 2021

The purpose of this narrative study is to describe the vaping and smoking characteristics of Queer people ages 18–34 before March of 2020 and to better understand how the COVID-19 pandemic has impacted those behaviors since March of 2020. In total, 31 participants were screened. Thirteen participants were screened prior to the emergence of COVID-19, and 18 were screened when study protocols transitioned to a remote setting (pre and during). Of the 27 eligible participants, a total of 25 participants completed the study. Most participants (n = 13) self-identified as male, followed by five identified as female, four self-identified as gender non-binary, and three identified as transgender. The most common sexual orientation amongst participants was gay (n = 10), with bisexual being the second-most reported. Approximately 20 Queer participants reported using cigarettes, 14 participants self-reported using electronic devices, and 11 reported using hookah. Twenty participants reported smoking ten or less, and four self-reported using 11–20 cigarettes per day. Approximately, 92% of participants (n = 23) indicate that they are using an e-cigarette and regular cigarettes, and 57% of participants (n = 12) report using one pod or cartridge per day. The three themes that emerged in this study are: (1) Queer people during COVID-19 are experiencing heightened minority stress; (2) Queer people are unfamiliar with smoking cessation; and (3) vaping and smoking are attributed to stress and anxiety. Queer participants are likely to be dual users of cigarette and vaping products. This present study provides increasing evidence that Queer people are experiencing heightened stress and anxiety and using cigarette smoking and vaping to cope during the COVID-19 pandemic.
Fluorescence Characteristics of Coalbed Methane Produced Water and Its Influence on Freshwater Bacteria in the South Qinshui Basin, China
Authors: Jin Tao , Meng Qingjun , Li Xiangdong , Zhou Lai
Published: December 2021

Production of coalbed methane (CBM) resources commonly requires using hydraulic fracturing and chemical production well additives. Concern exists for the existence of chemical compounds in CBM produced water, due to the risk of environmental receptor contamination. In this study, parallel factor method analysis (PARAFAC), fluorescence index, and the fluorescence area integral methods were used to analyse the properties of CBM produced water sampled from Shizhuang Block (one of the most active CBM-producing regions in the Qinshui Basin). A culture experiment was designed to determine the effect of discharged CBM produced water on microorganisms in freshwater. Water quality analysis shows the hydrochemistry of most water samples as Na-HCO3 type produced water of CBM appears as a generally weak alkaline (pH 8.69 ± 0.185) with high salinity, high alkalinity, and a high chemical oxygen demand (COD) value. Three individual components were identified by using parallel factor method analysis as humic-like components (C1), fulvic-like components (C2), and amino acid-like substances (C3). The fluorescence characteristic index comprehensively explains that the fluorescent substances in CBM produced water has the characteristics of a low degree of humification and a high recent self-generating source. The region integration results of characteristic peaks show that tyrosine-like and tryptophan-like materials account for more than 67% of fluorescent substances in CBM produced water. The addition of produced water from coalbed methane promotes the growth of freshwater bacteria, and this process is accompanied by the decrease of the proportion of fulvic acid, humic acid, and the increase of the proportion of soluble microbial metabolites. This paper proposes a convenient method for organic matter identification of CBM produced water and provides some theoretical support and reference for the improvement of CBM water treatment and utilization.
Below Average Cognitive Ability—An under Researched Risk Factor for Emotional-Behavioural Difficulties in Childhood
Authors: Bowe Andrea K. , Staines Anthony , Murray Deirdre M.
Published: December 2021

Children with below average cognitive ability represent a substantial yet under-researched population for whom cognitive and social demands, which increase in complexity year by year, may pose significant challenges. This observational study examines the longitudinal relationship between early cognitive ability and emotional-behavioral difficulties (EBDs) between the age of three and nine. Participants include 7134 children from the population-based cohort study growing up in Ireland. Cognitive ability was measured at age three using the Picture Similarities Scale. A t-score one to two standard deviations below the mean was defined as below average cognitive ability (n = 767). EBDs were measured using the Strengths and Difficulties Questionnaire (SDQ) at three, five, and nine years of age. Generalized linear mixed models and logistic regression were used to examine the relationship. Below average cognitive ability was an independent predictor of higher longitudinal SDQ scores. After adjustment, children with below average cognitive ability were 1.39 times more likely (AOR 1.39, 95% CI 1.17–1.66, p < 0.001) to experience a clinically significant EBD between the ages of three to nine years. This study demonstrates the increased risk of EBDs for children with below average cognitive ability. A scalable method of early identification of at-risk children should be a research priority for public health, enabling early intervention for cognitive and adaptive outcomes.
Comparison of Emergency Preparedness Practices between Food Assistance Program Participants and Non-Participants in the United States
Authors: Fung Gina J. , Jefferies Laura K. , Call Michelle A. Lloyd , Eggett Dennis L. , Richards Rickelle
Published: December 2021

Background: Previous research has suggested many households are meeting the Federal Emergency Management Agency’s 3-day emergency food and water storage recommendations. The impact of limited economic household resources on emergency preparedness practices related to food and water is uncertain. The purpose of this study was to compare emergency preparedness practices in households participating in United States’ food assistance programs with households not participating in these programs. Methods: A convenience sample of adults (n = 572) completed an online Qualtrics survey. Descriptive statistics, chi-square statistics, and independent t-tests were used to measure differences between households participating in food assistance programs vs. non-participating households. Results: Most households participating in food assistance programs felt prepared to provide household members with food and water during an emergency, which did not significantly differ from non-participating households. Households using food assistance programs had less accessible cash but had similar foods on-hand for an emergency compared to non-participating households. However, they more frequently reported having baby formula/food and less frequently reported having vitamin/mineral supplements compared to non-participating households. Conclusions: Food assistance programs may be effective in providing enough food and water to help low-income families be prepared for an emergency.
A Reliable and Efficient Tracking System Based on Deep Learning for Monitoring the Spread of COVID-19 in Closed Areas
Authors: Osman Radwa Ahmed , Saleh Sherine Nagy , Saleh Yasmine N. M. , Elagamy Mazen Nabil
Published: December 2021

Since 2020, the world is still facing a global economic and health crisis due to the COVID-19 pandemic. One approach to fighting this global crisis is to track COVID-19 cases by wireless technologies, which requires receiving reliable, efficient, and accurate data. Consequently, this article proposes a model based on Lagrange optimization and a distributed deep learning model to assure that all required data for tracking any suspected COVID-19 patient is received efficiently and reliably. Finding the optimum location of the Radio Frequency Identifier (RFID) reader relevant to the base station results in the reliable transmission of data. The proposed deep learning model, developed using the one-dimensional convolutional neural network and a fully connected network, resulted in lower mean absolute squared errors when compared to state-of-the-art regression benchmarks. The proposed model based on Lagrange optimization and deep learning algorithms is evaluated when changing different network parameters, such as requiring signal-to-interference-plus-noise-ratio, reader transmission power, and the required system quality-of-service. The analysis of the obtained results, which indicates the appropriate transmission distance between an RFID reader and a base station, shows the effectiveness and the accuracy of the proposed approach, which leads to an easy and efficient tracking system.
Bioavailability, Accumulation and Distribution of Toxic Metals (As, Cd, Ni and Pb) and Their Impact on Sinapis alba Plant Nutrient Metabolism
Authors: Vasile Gabriela-Geanina , Tenea Anda-Gabriela , Dinu Cristina , Iordache Ana Maria Mihaela , Gheorghe Stefania , Mureseanu Mihaela , Pascu Luoana Florentina
Published: December 2021

This study presents the behavior of white mustard seedlings Sinapis alba grown for three months in laboratory polluted soil containing As, Cd, Ni and Pb. Four different experiments were performed in which As was combined with the other three toxic metals in different combinations (As, AsCd, AsCdNi, AsCdNiPb), keeping the same concentrations of As and Cd in all tests and following the national soil quality regulations. The effects of these metals were monitored by the analytical control of metal concentrations in soil and plants, bioavailability tests of mobile metal fractions using three different extracting solutions (DTPA + TEA + CaCl2-DTPA, DTPA + CaCl2-CAT, and CH3COONH4 + EDTA-EDTA) and calculation of bioaccumulation and translocation factors. Additionally, micro, and macro-nutrients both in soil and plant (root, stem, leaves, flowers and seeds) were analyzed in order to evaluate the impact of toxic metals on plant nutrient metabolism. Metals were significantly and differently accumulated in the plant tissues, especially under AsCdNi and AsCdNiPb treatments. Significant differences (p < 0.05) in the concentration of both As and Cd were highlighted. Translocation could be influenced by the presence of other toxic metals, such as Cd, but also of essential metals, through the competition and antagonism processes existing in plant tissues. Significantly, more Cd and Ni levels were detected in leaves and flowers. Cd was also detected in seeds above the WHO limit, but the results are not statistically significant (p > 0.05). The extraction of metallic nutrients (Zn, Cu, Mn, Ni, Mg, K, Fe, Ca, Cr) in the plant was not influenced by the presence of toxic metal combinations, on the contrary, their translocation was more efficient in the aerial parts of the plants. No phytotoxic effects were recorded during the exposure period. The most efficient methods of metal extraction from soil were for As-CAT; Cd-all methods; Pb and Ni-DTPA. The Pearson correlations (r) between applied extraction methods and metal detection in plants showed positive correlations for all toxic metals as follows: As-CAT > DTPA > EDTA, Cd-DTPA > CAT > EDTA, Ni-EDTA = DTPA > CAT, Pb-EDTA = DTPA = CAT). The results revealed that Sinapis alba has a good ability to accumulate the most bioavailable metals Cd and Ni, to stabilize As at the root level and to block Pb in soil.
Adverse Effects of the COVID-19 Pandemic on Movement and Play Behaviours of Children and Youth Living with Disabilities: Findings from the National Physical Activity Measurement (NPAM) Study
Authors: Moore Sarah A. , Sharma Ritu , Martin Ginis Kathleen A. , Arbour-Nicitopoulos Kelly P.
Published: December 2021

All children and youth require ample physical activity (PA), low levels of sedentary behaviour (SB), and adequate sleep to stay healthy. Children and youth living with disabilities (CYWD) tend to have fewer opportunities for participation in PA and outdoor play compared with their typically developing peers. In turn, CYWD are typically less active and more sedentary, on average, compared with their peers. The COVID-19 pandemic reduced opportunities for many children and youth to participate in PA and outdoor play. The purpose of this study was to assess parent-perceived changes in PA (including outdoor play), SB (including screen time), and sleep quality and quantity, due to COVID-19 and related restrictions, in a national cohort of Canadian CYWD. We recruited parents of school-aged CYWD (N = 151) in May 2020. In an online survey, parents reported their child’s previous 7-day PA, SB, and sleep, as well as perceived changes in their child’s movement and play behaviours due to COVID-19 and related restrictions. Parent-perceived parental support for their child’s movement and play behaviours during the pandemic was also assessed. We used descriptive statistics to describe the child’s movement behaviours and assessed the association between movement behaviours and parental factors using Pearson and point-biserial correlations. Few (5.3%) CYWD met PA recommendations and 13.2% met screen time recommendations during the acute period of the COVID-19 pandemic. More CYWD (66.2%) were meeting sleep recommendations. Overall, only 1.3% of CYWD were meeting the combined movement guidelines. Parent encouragement was positively associated with the child’s outdoor PA (0.23), wheeling, walking, and biking (0.19), indoor PA (0.16), and family-based PA (0.26). Parental co-play was similarly positively associated with the child’s outdoor PA (0.26), wheeling, walking, and biking (0.39), indoor PA (0.16), and family-based PA (0.26). Parents perceived their CYWD to be less active and more sedentary as a result of COVID-19 and the related restrictions. Parents of CYWD have an important role in encouraging healthy movement behaviours. Return to movement and play post-COVID guidelines should include tailored strategies for CYWD and their families to mitigate the negative impacts of the pandemic.
Factors Associated with Psychological Distress in French Medical Students during the COVID-19 Health Crisis: A Cross-Sectional Study
Authors: Pelissier Carole , Viale Manon , Berthelot Philippe , Poizat Brigitte , Massoubre Catherine , Tiffet Theophile , Fontana Luc
Published: December 2021

Background: The purpose of this study was to assess the prevalence of psychological distress in medical students during the COVID-19 health crisis and to identify factors associated with psychological distress. Methods: A cross-sectional observational study was presented to 1814 medical students (from first to sixth year) in a French university hospital center. Sociodemographic, occupational and medical information (psychological distress measured on the French GHQ12 scale) were collected via an online anonymous self-administered questionnaire. Variables associated with psychological distress were investigated using univariate analysis and multivariate analysis (modified Poisson regression). Results: In total, 832 medical students responded (46%) and 699 completed the questionnaire in full (39%); 625 (75%) showed signs of psychological distress and 109 (15%) reported suicidal ideation. Female gender, psychological trauma during the COVID-19 health crisis, change in alcohol consumption, and difficulties with online learning emerged as risk factors for psychological distress, whereas a paid activity, a feeling of mutual aid and cooperation within the studies framework, and recognition of work appeared to be protective factors. Conclusions: Mental health care or suicide prevention should be provided to students at risk in the aftermath of the pandemic. Knowing the educational and medical factors associated with psychological distress enables areas for prevention to be identified.
Reliability and Validity of the Japanese Version of the 12-Item Psychosocial Safety Climate Scale (PSC-12J)
Authors: Inoue Akiomi , Eguchi Hisashi , Kachi Yuko , McLinton Sarven S. , Dollard Maureen F. , Tsutsumi Akizumi
Published: December 2021

The 12-item psychosocial safety climate scale (PSC-12) has been used extensively in previous research, but its reliability and validity in a Japanese context are still unknown. We examined the psychometrics of the Japanese version of the PSC-12 (PSC-12J). The PSC-12J and scales on the relevant variables were administered to 2200 employees registered with an online survey company. A follow-up survey with 1400 of the respondents was conducted two weeks later. Internal consistency and test–retest reliability were examined via Cronbach’s alpha and Cohen’s weighted kappa coefficients, respectively. Structural, convergent, and known-group validities were examined using confirmatory factor analysis (CFA) and item response theory (IRT) analysis, correlation analysis, and Kruskal–Wallis test, respectively. Cronbach’s alpha and Cohen’s weighted kappa coefficients were 0.97 and 0.53, respectively. CFA based on the four-factor structure established in the previous literature showed an acceptable model fit. IRT analysis showed that each item was an adequate measure of the respondent’s latent trait. Correlations of the PSC-12J with the relevant variables and distribution of scores by demographic characteristics were also observed in the theoretically expected directions, supporting the construct validity of the PSC-12J. Our findings establish the PSC-12J as a reliable and valid measure of the psychosocial safety climate construct in the Japanese context.
Can Major Public Health Emergencies Affect Changes in International Oil Prices?
Authors: Cheng An , Chen Tonghui , Jiang Guogang , Han Xinru
Published: December 2021

In order to deepen the understanding of the impact of major public health emergencies on the oil market and to enhance the risk response capability, this study analyzed the logical relationship between major public health emergencies and international oil price changes, identified the change points, and calculated the probability of abrupt changes to international oil prices. Based on monthly data during six major public health emergencies from 2009 to 2020, this study built a product partition model. The results show that only the influenza A (H1N1) and COVID-19 pandemics were significant reasons for abrupt changes in international oil prices. Furthermore, the wild poliovirus epidemic, the Ebola epidemic, the Zika epidemic, and the Ebola epidemic in the Democratic Republic of the Congo had limited effects. Overall, the outbreak of a Public Health Emergency of International Concern (PHEIC) in major global economies has a more pronounced impact on international oil prices.
Regression-Based Normative Data for Independent and Cognitively Active Spanish Older Adults: Free and Cued Selective Reminding Test, Rey–Osterrieth Complex Figure Test and Judgement of Line Orientation
Authors: Calderón-Rubio Eva , Oltra-Cucarella Javier , Bonete-López Beatriz , Iñesta Clara , Sitges-Maciá Esther
Published: December 2021

The aim of this work was to develop normative data for neuropsychological tests for the assessment of independent and cognitively active Spanish older adults over 55 years of age. Methods: regression-based normative data were calculated from a sample of 103 nondepressed independent community-dwelling adults aged 55 or older (66% women). The raw data for the Free and Cued Selective Reminding Test (FCSRT), the Rey–Osterrieth Complex Figure Test (ROCF) and the Judgement of Line Orientation Test (JLO) were regressed on age, sex and education. The model predicting the FCSRT delayed-recall (FCSRT-Del) scores also included the FCSRT immediate-recall (FCSRT-Imm) scores. The model predicting the ROCF immediate-recall (ROCF-Imm) scores included the ROCF copy-trial (ROCF-C) scores, and the model predicting the ROCF delayed-recall (ROCF-Del) scores included both the ROCF-C and the ROCF-Imm scores. In order to identify low scores, z-scores were used to determine the discrepancy between the observed and the predicted scores. The base rates of the low scores for both the SABIEX normative data and the published normative data obtained from the general population were compared. Results: the effects of the different sociodemographic variables (age, sex and education) varied throughout the neuropsychological measures. Despite finding similar proportions of low scores between the normative data sets, the agreement was irrelevant or only fair-to-good. Conclusions: the normative data obtained from the general population might not be sensitive enough to identify low scores in cognitively active older adults, incorrectly classifying them as cognitively normal compared to the less active population.
A Comparison of Combustion Properties in Biomass–Coal Blends Using Characteristic and Kinetic Analyses
Authors: Wang Yalin , Yan Beibei , Wang Yu , Zhang Jiahao , Chen Xiaozhong , Bastiaans Rob J. M.
Published: December 2021

This paper presents comparative research on the combustion of coal, wheat, corn straw (CS), beet residues after extracting sugar (BR), and their blends, coal–corn straw blends (CCSBs), coal–wheat blends (CWBs), and coal–beet residue blends (CBRBs), using thermogravimetric (TG) analysis under 10, 20, 30, 40 and 50 °C/min. The test results indicate that CS and wheat show better combustion properties than BR, which are recommended to be used in biomass combustion. Under the heating rate of 20 °C/min, the coal has the longest thermal reaction time when compared with 10 and 30 °C/min. Adding coal to the biomass can improve the burnout level of biomass materials (BM), reduce the burning speed, and make the reaction more thorough. The authors employed the Flynn–Wall–Ozawa (FWO) method and the Kissinger–Akahira–Sunose (KAS) method to calculate kinetics parameters. It was proven that overall, the FWO method is better than the KAS method for coal, BM, and coal–biomass blends (CBBs), as it provides higher correlations in this study. It is shown that adding coal to wheat and BR decreases the activation energy and makes conversion more stable under particular α. The authors selected a wider range of biomass raw materials, made more kinds of CBB, and conducted more studies on different heating rates. This research can provide useful insights into how to choose agricultural residuals and how to use them.
Relationships of Sexual Orientation Microaggression with Anxiety and Depression among Lesbian, Gay, and Bisexual Taiwanese Youth: Self-Identity Disturbance Mediates but Gender Does Not Moderate the Relationships
Authors: Chen Jung-Sheng , Huang Yu-Te , Lin Chung-Ying , Yen Cheng-Fang , Griffiths Mark D. , Pakpour Amir H.
Published: December 2021

The aims of this cross-sectional survey study were to examine the association between sexual orientation microaggression and anxiety and depression among young adult lesbian, gay, and bisexual (LGB) individuals in Taiwan, as well as to examine the mediating effect of self-identity disturbance and the moderating effect of gender. In total, 1000 self-identified LGB individuals participated in the study. The experience of sexual orientation microaggression was assessed using the Sexual Orientation Microaggression Inventory, self-identity disturbance was assessed using the Self-Concept and Identity Measure, anxiety was assessed using the State subscale on the Chinese version of the State-Trait Anxiety Inventory, and depression was assessed using the Center for Epidemiological Studies-Depression Scale. Structural equation modeling (SEM) was used to examine relationships between the variables. The SEM results demonstrated that sexual orientation microaggression was directly associated with increased anxiety and depression, as well as being indirectly associated with increased anxiety and depression via the mediation of self-identity disturbance among young adult LGB individuals. Gender did not moderate the relationships between any of the variables. Both sexual orientation microaggression and self-identity disturbance warrant program interventions for enhancing mental health among LGB individuals.
Moving around a Large City in Latin America: The Mobility Challenges Faced by Older Adults with Disabilities
Authors: Prieto-Flores María-Eugenia , Rosenberg Mark W.
Published: December 2021

A growing body of research has shown that barriers in the urban environment can be disabling by reducing the ability of older people to manage independently in the community, but also because they can negatively affect health by limiting the possibilities to move outside the home. In this study, we ask how obstacles in the urban environment are associated with the need for help to go to places in the community. To respond to this question, we used the Annual Household Survey of the City of Buenos Aires, Argentina 2018, which had a specific questionnaire for people with disabilities. From this sample, we selected adults aged 65 years or older with difficulties in at least one of six domains: vision; hearing; upper and lower body mobility; cognition; self-care; and communication. The final sample consisted of 513 persons (weighted = 109,316). First, we conducted a principal component analysis identifying three factors from variables of obstacles to access and use the urban environment: transportation; outdoor spaces; and information. Second, through a logistic regression model, we observed a direct relationship between these factors and the need for help to move in the community, controlling for sociodemographic characteristics, health status, and number of disabilities. This paper provides evidence on the significance of improving urban spaces to reduce dependent mobility. In Latin America, cities still face many challenges in becoming more age-friendly.
Motivation to Move Out of the Community as a Moderator of Bullying Victimization and Delinquent Behavior: Comparing Non-Heterosexual/Cisgender and Heterosexual African American Adolescents in Chicago’s Southside
Authors: Hong Jun Sung , Zhang Saijun , Garthe Rachel C. , Hicks Megan R. , deLara Ellen W. , Voisin Dexter R.
Published: December 2021

A growing body of research documents that bullying victimization is associated with delinquent behavior. There is an increasing need to better illuminate the factors that might moderate this relationship. This study examined whether the motivation to move out of low-resourced neighborhoods and sexual orientation/gender identity moderated the relationship between bullying victimization and delinquent behavior among a sample of 450 heterosexual and 91 non-heterosexual/cisgender African American youths. Measures considered were bullying victimization, delinquent behavior, sexual orientation/gender identity, motivation to move out, and family demographics. Sexual orientation/gender identity was not associated with youth delinquent behavior after controlling for covariates. Being motivated to move out moderated the association between bullying victimization and delinquent behavior. Sexual orientation/gender identity and being motivated to move out of low-resourced communities jointly contributed to the moderating effect between bullying victimization and delinquent behavior. For non-heterosexual/cisgender youth, bullying victimization is correlated with increased delinquent behavior for those with low motivation to move out of their communities compared with those with an average or higher level of motivation to stay. However, such a moderating effect was not shown for heterosexual youth.
Choosing and Managing Aged Care Services from Afar: What Matters to Australian Long-Distance Care Givers
Authors: Gunn Kate M. , Luker Julie , Ramanathan Rama , Skrabal Ross Xiomara , Hutchinson Amanda , Huynh Elisabeth , Olver Ian
Published: December 2021

This research aims to identify the factors that influence caregivers’ decisions about the aged care providers they select for their elder relatives when caring from a distance and what they value once they have engaged a service. Adult long-distance carers for older relatives living within Australia were purposively sampled and they participated in audio-recorded interviews. A thematic analysis was employed to investigate the data. A sample of 13 participants enabled data saturation with no new major themes identified in the final three interviews. Participants were 50 to 65 years (Mean = 59.8) and mostly (77%) female. Four themes emerged relating to selection of care providers: (1) availability of care, (2) financial arrangements, (3) proximity and location, and (4) reputation of care provider. Five themes detailed valued qualities of care: (1) vigilant monitoring and responsivity, (2) communication with family, (3) flexibility and proactiveness of care, (4) staffing, and (5) access to appropriate and holistic care to maintain wellbeing. Long-distance caregivers face barriers in selecting and managing aged care services from afar within a complex Australian aged care system. They strongly value regular, proactive communication about the wellbeing of their relatives and may be particular beneficiaries of communication and assistive monitoring technologies.
Gratitude Moderates the Relation between Daily Hassles and Satisfaction with Life in University Students
Authors: Tachon Guillaume , Shankland Rebecca , Marteau-Chasserieau Fanny , Morgan Blaire , Leys Christophe , Kotsou Ilios
Published: December 2021

Satisfaction with life as a judgmental cognitive process can be negatively influenced by appraisals of daily events such as hassles. Trait-gratitude—a tendency to appraise, recognize and respond to life events through being grateful—is a determinant of mental health and well-being, and has been shown to be related to the positive appraisal of life. The aim of the current study was to investigate the moderating role of trait-gratitude in the relationship between daily hassles and satisfaction with life. In the process of carrying out this study, the French version of the Gratitude Questionnaire (GQ-6) was validated. A total of 328 French undergraduates completed questionnaires measuring gratitude, satisfaction with life, and daily hassles to test the main hypothesis. They also completed optimism, coping strategies, depression, and anxiety questionnaires in order to assess the convergent validity of the French version of the GQ-6. First, the results showed satisfactory psychometric properties of the Gratitude Questionnaire. Second, the results indicated the moderating role of trait-gratitude in the relationship between daily hassles disturbance and satisfaction with life. This study further documents the role of gratitude as a determinant of well-being and provides French-speaking clinicians and researchers with a useful tool to measure grateful disposition.
When Pregnancy Coincides with Positive Diagnosis of HIV: Accounts of the Process of Acceptance of Self and Motherhood among Women in South Africa
Authors: Madiba Sphiwe
Published: December 2021

Literature has highlighted the unique period of vulnerability following an HIV diagnosis during pregnancy. Despite the high burden of HIV among pregnant women in South Africa, the experiences of women diagnosed with HIV during pregnancy have rarely been explored in isolation from those diagnosed at different times. This paper explored the experiences of women who were diagnosed with HIV when pregnant and assessed their emotional recovery beyond diagnosis. The study used a qualitative descriptive phenomenological approach to conduct interviews with women recruited from ART clinics in a health district in South Africa. Participants included 19 women sampled purposively. The interviews were transcribed verbatim and analysed following the thematic approach. Testing positive during pregnancy and being free of symptoms increased the shock, disbelief, and strong emotions exhibited. For the women, the diagnosis of HIV coincided with pregnancy and transformed pregnancy from excitement to anxiety. Although the transition from being HIV negative to becoming HIV positive and pregnant was overwhelming, with the passage of time, the women transitioned to feelings of acceptance. However, the process of acceptance was slow and varied, with some experiencing non-acceptance for extended periods. Non-acceptance of HIV diagnosis has serious adverse public health consequences for the individual. Integrating continuous HIV counselling and culturally appropriate psychosocial care into practice could foster acceptance for pregnant women with HIV diagnosis.