bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
Authors: Puertas-Bartolomé María , Vázquez-Lasa Blanca , San Román Julio
Published: June 2018

The effective treatment for chronic wounds constitute one of the most common worldwide health care problem due to the presence of high levels of proteases, free radicals and exudates in the wound, which constantly activate the inflammatory system avoiding the tissue regeneration. In this study, we describe a multifunctional bioactive and resorbable membrane with in-built antioxidant agent for the continuous quenching of free radicals as well as to control inflammatory response helping to promote the wound healing process. To reach that goal synthesized statistical copolymers of N-vinylcaprolactam (V) and 2-hydroxyethyl methacrylate (H) have been conjugated with catechol bearing hydrocaffeic acid (HCA) molecules. The natural polyphenol (catechol) is the key molecule responsible for the mechanism of adhesion of mussels, and provides the functionalized polymer conjugate a continuous antioxidant response, antiinflammatory effect, UV screen and bioadhesion in the moist environment of the human body, all of them key features in the wound healing process. Therefore, these novel mussel-inspired materials have an enormous potential of application and can act very positively, favoring and promoting the healing effect in chronic wounds.
Anger and Aggression in UK Treatment-Seeking Veterans with PTSD
Authors: Turgoose David , Murphy Dominic
Published: June 2018

Prevalence rates of anger and aggression are often higher in military personnel, so it is important to understand more about why this is and factors with which they are associated. Despite this, there is little evidence relating to anger and aggression in UK veterans who are seeking treatment for mental health difficulties such as PTSD. This study investigated the prevalence rates of anger and aggression in this population, as well as the associations between anger and aggression, and various sociodemographic, functioning and mental health variables. A cross-sectional design was used, with participants completing a battery of self-report questionnaires. Prevalence rates for significant anger and aggression were 74% and 28% respectively. Both women and those over 55 were less likely to report difficulties. Those with high levels of PTSD and other mental health difficulties were more likely to report anger and aggression. Other factors related to anger and aggression included childhood adversity; unemployment due to ill health; and a perceived lack of family support. Findings show that veterans who are seeking support for mental health are likely to experiencing significant difficulties with anger and aggression, especially if they have co-morbid mental health difficulties. The associations between anger and aggression and other variables has implications for the assessment and treatment of military veterans.
(+)-epi-Epoformin, a Phytotoxic Fungal Cyclohexenepoxide: Structure Activity Relationships
Authors: Cala Antonio , Masi Marco , Cimmino Alessio , Molinillo José M.G. , Macías Francisco A. , Evidente Antonio
Published: June 2018

(+)-epi-Epoformin (1), is a fungal cyclohexene epoxide isolated together with diplopimarane and sphaeropsidins A and C, a nor-ent-pimarane and two pimaranes, from the culture filtrates of Diplodia quercivora, a fungal pathogen for cork oak in Sardinia, Italy. Compound 1 possesses a plethora of biological activities including: antifungal, zootoxic and phytotoxic activity. The last activity and the peculiar structural feature of 1 suggested to carry out a structure activity relationship study, preparing eight key hemisynthetic derivatives and their phytotoxicity was assayed. The complete spectroscopic characterization and the activity in the etiolated wheat coleoptile bioassay of all the compounds is reported. Most of the compounds inhibited growth and some of them had comparable or higher activity than the natural product and the reference herbicide Logran. As regards the structure-activity relationship, the carbonyl proved to be essential for their activity of 1, as well as the conjugated double bond, while the epoxide could be altered with no significant loss.
Opportunities and Challenges in Data-Driven Healthcare Research
Authors: Chen You
Published: June 2018

Health information technology has been widely used in healthcare, which has contributed a huge amount of data. Health data has four characteristics: high volume; high velocity; high variety and high value. Thus, they can be leveraged to i) discover associations between genes, diseases and drugs to implement precision medicine; ii) predict diseases and identify their corresponding causal factors to prevent or control the diseases at an earlier time; iii) learn risk factors related to clinical outcomes (e.g., patients’ unplanned readmission), to improve care quality and reduce healthcare expenditure; and iv) discover care coordination patterns representing good practice in the implementation of collaborative patient-centered care. At the same time, there are major challenges existing in data-driven healthcare research, which include: i) inefficient health data exchanges across different sources; ii) learned knowledge is biased to specific institution; iii) inefficient strategies to evaluate plausibility of the learned patterns and v) incorrect interpretation and translation of the learned patterns. In this paper, we review various types of health data, discuss opportunities and challenges existing in the data-driven healthcare research, provide solutions to solve the challenges, and state the important role of the data-driven healthcare research in the establishment of smart healthcare system.
Estimation of Cough Peak Flow Using Cough Sounds
Authors: Umayahara Yasutaka , Soh Zu , Sekikawa Kiyokazu , Kawae Toshihiro , Otsuka Akira , Tsuji Toshio
Published: June 2018

Cough peak flow (CPF) is a measurement to evaluate the risk of cough dysfunction and can be measured using various devices, such as spirometers. However, complex device setup and the face mask required to be firmly attached to the mouth impose burdens on both patients and their caregivers. Therefore, this study develops a novel cough strength evaluation method using cough sounds. This paper presents an exponential model to estimate CPF from the cough peak sound pressure level (CPSL). We investigated the relationship between cough sounds and cough flows and the effects of a measurement condition of cough sound, microphone type, and participant’s height and gender on CPF estimation accuracy. The results confirmed that the proposed model estimated CPF with a high accuracy. The absolute error between CPFs and estimated CPFs were significantly lower when the microphone distance from the participant’s mouth was within 30 cm than when the distance exceeded 30 cm. Analysis of the model parameters showed that the estimation accuracy was not affected by participant’s height or gender. These results indicate that the proposed model has the potential to improve the feasibility of measuring and assessing CPF.
Papel de la gastronomía y las nuevas tecnologías en la configuración de una alimentación saludable
Authors: Aranceta Bartrina Javier
Published: June 2018

-
Biotecnología de alimentos: de los transgénicos a la nutrición personalizada
Authors: Ramón Vidal Daniel
Published: June 2018

-
Retos actuales de la investigación en nutrición aplicada: ¿persona o población?
Authors: Gil Hernández Ángel
Published: June 2018

-
¿Conocemos lo que comemos? Una perspectiva nutricional
Authors: Martínez de Victoria Muñoz Emilio
Published: June 2018

-
Papel de las organizaciones de consumidores en la alfabetización alimentaria de la población
Authors: Moreno Rodríguez Juan
Published: June 2018

-
ALIMENTACIÓN 3.0: aspectos de interés en la práctica diaria
Authors: Pérez Rodrigo Carmen
Published: June 2018

-
PAUTAS DIETÉTICAS EN LA DIABETES Y EN LA OBESIDAD
Authors: Riobo Pilar
Published: June 2018

-
Atención a comensales con dieta específica en los servicios de restauración a colectividades
Authors: De Diego Blanco Beatriz Susana
Published: June 2018

-
Sistemas de encapsulación y liberación controlada basados en el uso de puertas moleculares
Authors: Ruiz-Rico María
Published: June 2018

-
Fixation Options Following Greater Trochanteric Osteotomies and Fractures in Total Hip Arthroplasty
Authors: Mei Xin Y. , Gong Ying Jia , Safir Oleg A. , Gross Allan E. , Kuzyk Paul R.
Published: June 2018

Background:

The optimal system for greater trochanteric fixation following osteotomy or fracture remains unknown. This systematic review aims to synthesize the available English-language literature on 5 commonly reported trochanteric fixation methods to quantify and compare rates of complications and reoperation.

Methods:

A comprehensive search of MEDLINE and Embase databases from January 1946 to June 2017 was performed for articles in English describing fixation of trochanteric osteotomies and fractures using wires, cables, cable-plate devices, claw or locking plates, and trochanteric bolts. Pooled mean rates of complications and reoperation with 95% confidence intervals (CIs) were analyzed using a random-effects model.

Results:

Fifty-seven studies involving 10,956 hips were eligible for inclusion. Five studies had Level-III evidence and 52 had Level-IV evidence. The pooled mean rate of nonunion was 4.17% (95% CI, 3.21% to 5.13%; I2 = 79%) for wires, 5.07% (95% CI, 0.37% to 9.77%; I2 = 74%) for cables, 16.11% (95% CI, 10.85% to 21.37%; I2 = 89%) for cable-plate systems, 9.60% (95% CI, 2.23% to 16.97%; I2 = 59%) for claw or locking plates, and 12.42% (95% CI, 3.41% to 21.43%; I2 = 75%) for trochanteric bolts. Substantial heterogeneity in the data precluded formal statistical comparison of outcomes and complications between implants.

Conclusions:

Available literature on the various trochanteric fixation implants is heterogeneous and consists primarily of retrospective case series. Based on the current literature, it is difficult to support the use of one implant over another. Despite superior mechanical properties, rates of complication and reoperation following cable-plate fixation remains suboptimal, especially in complex revision scenarios. Additional rigorous prospective randomized and cohort studies are needed to make definitive recommendations regarding the most reliable method of trochanteric fixation.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Factores pronósticos en pacientes con cáncer de mama y metástasis cerebral como primer sitio de recurrencia
Authors: Mohar-Betancourt Alejandro , Alvarado-Miranda Alberto , Torres-Domínguez Juan Alejandro , Cabrera Paula , Lara Medina Fernando , Villarreal-Gómez Yaudim Sadid , Reynoso-Noverón Nancy
Published: June 2018

Objetivo. Evaluar los factores pronósticos (características clínico-patológicas y tratamientos) en las pacientes con cáncer de mama y metástasis al sistema nervioso central (SNC) como primer sitio de afección. Material y métodos. Cohorte retrospectiva, formada por 125 pacientes con cáncer de mama atendidas en el Instituto Nacional de Cancerología durante 2007-2015, quienes presentaron afección en el SNC como primer sitio de metástasis. A través del método Kaplan-Meier y tablas de vida se estimó la supervivencia global. El modelo de riesgos proporcionales de Cox fue utilizado para determinar los factores pronósticos. Resultados. La mediana de super­vivencia global fue de 14.2 meses (IC95% 11.8-26.9). Pacientes clasificadas por inmunohistoquímica como triple negativo (TN) presentaron tiempos de supervivencia más cortos (p<0.004) y con dos veces más riesgo de fallecer, en com­paración con los otros inmunofenotipos (HR= 2.77; IC95% 1.10-6.99); asimismo, se identificó que un grado intermedio en la escala Scarff-Bloom-Richardson incrementa el riesgo de morir en pacientes con metástasis (HR=2.76; IC95% 1.17- 6.51). Conclusiones. La metástasis al SNC continúa siendo un factor de mal pronóstico que reduce la supervivencia y afecta la calidad de vida. Se recomienda vigilar puntualmente la presencia de manifestaciones clínicas neurológicas durante el seguimiento, para una rápida intervención. Las pacientes TN tienen peor pronóstico, y las HER2+ (es decir, con resultado positivo para el receptor 2 del factor de crecimiento humano epidérmico), mejor control a mediano plazo.
Competitive Advantages of Small Medium Industry on the Islands in Indonesian Context
Authors: Kurniawan Muslim El Hakim , Yudoko Gatot , Basri Mursyid Hasan
Published: June 2018

Indonesian Law No.3/2014 regarding Industry requires both Central and Local Governments to realize the competitiveness of small and medium industries. However, the fact that the condition of each region is not similar becomes a main problem. It is because Indonesia is an archipelagic country. The competitiveness index of Asia Competitiveness Institute 2015 indicates that islands provinces, such as Kepulauan Bangka Belitung, Nusa Tenggara Barat, Nusa Tenggara Timur, Sulawesi Utara, Maluku, Maluku Utara, Sulawesi Tenggara, need specific development strategies. They cannot be equated with the  mainlands, such as Java and Sumatera, because their competitiveness rank is very low. A review of literature on the competitiveness of islands entrepreneurs shows that from the 4 (four) schools of thought in competitive advantage, only few researchers have pertained on the knowledge based on the schools of thought. Therefore, this could be a future research opportunity.
Development of platinum supported on single-walled carbon nanotubes by deposition-precipitation for microbial fuel cells
Authors: Pusomjit P. , Chailapakul O. , Ng H. Y. , Thepsuparungsikul N.
Published: June 2018

Microbial fuel cells (MFCs) are an ecologically friendly technology that can recover electricity and simultaneously treat wastewater. Among all the influential factors, cathode material and catalyst play a crucial role in electricity production and oxygen reduction. In this study, Pt nanocatalysts deposited on single-walled carbon nanotubes (Pt/SWCNTs) were synthesized by the deposition-precipitation (DP) method under optimal conditions. The results show that DP might be a promising method for the preparation of Pt/SWCNTs due to its simple, cost-effective and time-saving procedure, in addition to being highly efficient at creating small Pt particles (0.9 nm) that were very uniformly distributed. The synthesized Pt/SWCNTs suspension was spray-coated on to carbon cloth and then used as a cathode for MFCs. The electricity generation of MFCs equipped with a Pt/SWCNTs cathode was evaluated in terms of open circuit voltage (0.6954 V), internal resistance (63.3 Ω•m2) and maximum power density (2,022 mW/m2). The chemical oxygen demand removal, biological oxygen demand removal, total dissolved solids removal, total suspended solids removal and silver recovery was satisfactory at 84.5%, 74.0%, 45.7%, 60.0% and 99.0%, respectively. Therefore, Pt/SWCNTs from the DP method was identified as a potential candidate to replace commercial Pt-carbon cloth for MFC cathodes.
Produção e qualidade de mudas de Psidium cattleianum var. cattleianum Sabine (Myrtaceae) em diferentes substratos
Authors: Marques Alan Richar Freitas , Oliveira Viviane Da Silva , Boligon Alexandra Augusti , Vestena Silvane
Published: June 2018

Analisou-se o uso de lodo de esgoto como substrato na produção de mudas de Psidium cattleianum var. cattleianum Sabine. Os tratamentos foram: T1 (50% substrato comercial Plantmax® + 50% cama de equino, tido como composto orgânico), T2 (20% lodo de esgoto + 80% composto orgânico), T3 (40% + 60%) e T4 (60% + 40%). Os tratamentos foram arranjados em delineamento inteiramente casualizado, com cinco repetições por tratamento com 50 sementes cada. Os dados foram submetidos à análise de variância e as médias discriminadas pelo teste de Tukey a 5% de probabilidade. A cada três dias, durante 90 dias, realizou-se a contagem de plântulas que emergiram, para posterior cálculo de índice de velocidade de emergência. Decorridos 180 dias após a semeadura, foi calculada a porcentagem de emergência, foram verificadas as características biométricas e foi calculado o índice de qualidade de Dickson. A utilização do substrato comercial associado a cama de equino proporcionou as menores médias para todas as características avaliadas. Os tratamentos com lodo de esgoto associado ao composto orgânico apresentaram os melhores resultados para as características morfológicas avaliadas, sendo o tratamento 3 aquele com os melhores resultados.
Fator de forma artificial para Pinus taeda L. em um povoamento localizado em Enéas Marques, PR
Authors: Atanazio Kemely Alves , Vuaden Elisabete , Krefta Sandra Mara , Klein Danieli Regina , Baldisera Schorr Luis Paulo , Cuchi Tarik , De Arruda Souza Isadora , Gorenstein Mauricio Romero , Mota Lima Pereira Hudson
Published: June 2018

O estudo teve como objetivo determinar um fator de forma artificial para Pinus taeda no município de Enéas Marques, localizado no sudoeste do Paraná. Primeiramente foi realizado o inventário florestal da área, utilizando como método de amostragem o de área fixa e o processo sistemático, instalando 15 parcelas de 600 m². Para determinar o fator de forma artificial, realizou-se a cubagem rigorosa de 16 árvores; destas, oito de diâmetro de área basal médio (dg) e oito árvores dominantes, com base no método de Smalian. Os diâmetros foram medidos a 0,10; 0,30; 0,70; 1,30 m; depois de 1,0 m em 1,0 m. Após determinou-se o fator de forma para cada árvore cubada, o qual foi obtido pela relação entre o volume rigoroso e o volume do cilindro a 1,30 m das árvores cubadas. Encontraram-se valores médios de fator de forma igual a 0,52 para árvores dg e 0,48 para árvores dominantes. O valor médio total para 16 árvores cubadas foi de 0,50 e um volume total de 168,22 m3/ha. Os resultados encontrados revelaram que árvores com menor diâmetro apresentam fator de forma maior, quando comparadas com árvores de diâmetro maior.
Qualidade visual da paisagem do Parque Bacacheri, Curitiba – Paraná
Authors: Dias de Oliveira Jefferson , Nunho dos Reis Allan Rodrigo , Biondi Daniela
Published: June 2018

A avaliação da paisagem permite compreender uma área como um sistema de unidades territoriais inter-relacionadas e com características ambientais específicas. O objetivo deste estudo foi avaliar a qualidade visual da paisagem do Parque Bacacheri – Curitiba/PR, com vistas a conhecer os seus pontos de maior e menor expressão visual. Utilizaram-se o método indireto, por meio de dados cartográficos e SIG, com a definição de três classes de qualidade visual – RUIM (valor inferior), MÉDIA e BOA (valor superior) –, e o método direto, com coleta dos dados in loco nos locais que representavam os centros das três classes de qualidade visual, com a tomada de fotografias. Das quadrículas avaliadas no método indireto, 18,75% foram enquadradas na classe RUIM, 37,5% na classe MÉDIA e 43,75% na classe BOA. No método direto, 41,67% das fotografias foram enquadradas na classe RUIM, 50% na classe MÉDIA e 8,33% na classe BOA. Não foi constatada diferença estatística significativa entre pontos amostrais nem entre os sentidos de observação, indicando que não há variação entre as paisagens amostradas. A utilização conjunta dos dois métodos mostrou-se eficaz para a avaliação da qualidade visual da paisagem do parque. Recomenda-se que nas áreas com menor aptidão estética sejam feitas melhorias para apreciação visual.
Levantamento etnobotânico da Universidade Federal de Campina Grande, Campus Pombal
Authors: De Oliveira Sousa Valéria Fernandes , Lopes dos Santos Gisele , Silva Rodrigues Marília Hortência Batista , Ferreira Barroso Roberto , Costa Leitão Erllan Tavares , Dos Santos José Jaciel Ferreira
Published: June 2018

A caatinga representa um importante patrimônio brasileiro, destacando-se pela diversidade de espécies. Contudo é um bioma que vem sofrendo com a degradação ocasionada principalmente pelo processo de urbanização. A arborização, empregando espécies nativas e sua identificação em parques, praças e ambientes educacionais modificados por esse processo, é vista como alternativa para a diminuição da degradação ambiental e a preservação do bioma. Nessa perspectiva, objetivou-se realizar um levantamento etnobotânico da área urbanizada pela Universidade Federal de Campina Grande, campus Pombal. Para isso, foi realizada a quantificação das espécies, com coletas efetuadas no período de dezembro de 2017 a janeiro de 2018. As espécies encontradas foram identificadas com auxílio do Herbário Virtual da Flora e dos Fungos – Instituto Nacional de Ciência e Tecnologia e do Manual de Identificação de Plantas Arbóreas Nativas do Brasil. Registraram-se 567 indivíduos, distribuídos em 48 espécies e 27 famílias botânicas. Dentre estas, nim (Azadirachta indica), espécie exótica, apresentou maior população, seguida por jurema (Mimosa tenuiflora), nativa da caatinga. A família que mais se destacou foi Fabaceae, seguida de Meliaceae. Verifica-se que as espécies exóticas predominaram sobre as nativas e que há necessidade do correto planejamento da arborização na localidade.
Kinetics and Mechanism of the Formation of Ylides, 1, 4 or 1, 5-Diionic Organophosphorus and Phosphonate Esters: A Review
Authors: Habibi-Khorassani Sayyed Mostafa , Shahraki Mehdi , Mostafa Bahareh
Published: June 2018

The kinetics and mechanism of the formation of some ylides,1,4 or 1,5-diionic organophosphorus and phosphonate esters have been reviewed. The UV-vis spectrophotometry, stopped-flow and variable-temperature 1H-NMR spectroscopy along with the theoretical calculations were used as investigative techniques.
Advances in the Mitsunobu Reaction: An Excellent Organic Protocol with Versatile Applications
Authors: Panday Sharad Kumar
Published: June 2018

The beginning of 1970’s may well be regarded as turning point in the area of organic synthesis
when an efficient and straight forward strategy for the reaction of primary and/or secondary alcohols
with variety of nucleophiles in the presence of triphenylphosphine and azodicarboxylate reagent was
discovered by O. Mitsunobu and since then rapid progress has been made in understanding and applying
the Mitsunobu reaction for various derivatization reactions. Due to versatile applications and mild reaction
conditions associated with the said strategy, the Mitsunobu reaction has received much attention in
the last almost fifty years and has been well reported. The basic objective of this review is to pay attention
on the recent advances and applications of the Mitsunobu reaction particularly in last decade. The
attention has also been paid to describe various modifications which have been explored in the traditional
Mitsunobu reaction by substituting P (III) reagents or azodicarboxylate reagents with other suitable
reagents or else using an organocatalyst with the objective to improve upon the traditional Mitsunobu
reaction. In the present review we wish to report the major advancements achieved in last few years
which are likely to be beneficial for the researchers across the globe.
Statins: A Conceivable Remedial Role for the Regulation of Cancer Progression
Authors: Sherbet Gajanan V.
Published: June 2018

The mevalonate pathway (also known as the cholesterol biosynthesis pathway) plays a crucial metabolic role in normal cell function as well as in the pathological environment. It leads to the synthesis of sterol and non-sterol isoprenoid biomolecules which subserve a variety of cellular functions. It is known to be deregulated in many disease processes. Statins and bisphosphonates are prominent inhibitors of the mevalonate pathway. They inhibit cell proliferation and activate apoptotic signalling and suppress tumour growth. Statins subdue metastatic spread of tumours by virtue of their ability to suppress invasion and angiogenesis. The induction of autophagy is another feature of statin effects that could contribute to the suppression of metastasis. Herein highlighted are the major signalling systems that statins engage to generate these biological effects. Statins can constrain tumour growth by influencing the expression and function of growth factor and receptor systems. They may suppress epithelial mesenchymal transition with resultant inhibition of cell survival signalling, together with the inhibition of cancer stem cell generation, and their maintenance and expansion. They can suppress ER (oestrogen receptor)-α in breast cancer cells. Statins have been implicated in the activation of the serine/threonine protein kinase AMPK (5' adenosine monophosphate-activated protein) leading to the suppression of cell proliferation. Both statins and bisphosphonates can suppress angiogenic signalling by HIF (hypoxia- inducible factor)-1/eNOS (endothelial nitric oxide synthase) and VEGF (vascular endothelial growth factor)/VEGFR (VEGF receptor). Statins have been linked with improvements in disease prognosis. Also attributed to them is the ability of cancer prevention and reduction of risk of some forms of cancer. The wide spectrum of cancer associated events which these mevalonate inhibitors appear to influence would suggest a conceivable role for them in cancer management. However, much deliberation is warranted in the design and planning of clinical trials, their scope and definition of endpoints, modes risk assessment and the accrual of benefits.
An Overview of Galenic Preparation Methods for Medicinal Cannabis
Authors: Romano Luigi , Hazekamp Arno
Published: June 2018

In recent years, the Cannabis plant (Cannabis sativa L.) has been rediscovered as a source of new medicines around the world. Despite the fact that a number of registered medicines have been developed on the basis of purified cannabis components, there is a rapid increasing acceptance and use of cannabis in its herbal form. Licensed producers of high quality cannabis plants now operate in various countries including The Netherlands, Canada, Israel, and Australia, and in many US states. The legal availability of cannabis flowers allows to prescribe and prepare different cannabis galenic preparations by pharmacists. It is believed that synergy between cannabis components, known as “entourage effect”, may be responsible for the superior effects of using herbal cannabis versus isolated compounds. So far, only a few cannabis components have been properly characterized for their therapeutic potential, making it unclear which of the isolated compounds should be further developed into registered medicines. Until such products become available, simple and accessible galenic preparations from the cannabis plant could play an important role. In cannabis, phytochemical and pharmacological attention has been attributed mainly to four major cannabinoids (Δ9- tetrahydrocannabinol, cannabidiol, cannabigerol and cannabichromene) and to terpene components. This means a basic knowledge of these compounds and their bioavailability in different administration forms is useful for producers as well as prescribers of galenic preparations. This work will outline the most important aspects of cannabinoids and terpenes, and their behaviors during preparation and use of various administration forms including vaporizing, cannabis oils and extracts, tea, and skin creams.
A Pilot Study of Plasma Antipsychotic Drugs Concentrations of First Episode Patients with Psychosis From Epirus - Greece
Authors: Boumba Vassiliki A. , Petrikis Petros , Patteet Lisbeth , Baou Maria , Rallis Georgios , Metsios Apostolos , Karampas Andreas , Maudens Kristof , Mavreas Venetsanos
Published: June 2018

Background:

This contribution is a study on plasma antipsychotics concentrations
of first episode outpatients with psychosis (FEPs), under antipsychotic treatment; it aims to
attract attention to the importance of the drug-driven management of psychiatric patients for
improving adherence and clinical efficacy.

Methods:

The plasma antipsychotic concentrations were determined retrospectively (after the
completion of selection of all samples) and therefore, they were not used to monitor patients’
response to pharmacotherapy. A total of 120 plasma samples from 35 psychiatric patients
were collected and tested for antipsychotics. The concentrations of eight antipsychotic drugs
(amisulpride, aripiprazole, clozapine, haloperidol, olanzapine, quetiapine, risperidone and
paliperidone) and seven of their metabolites were determined.

Results:

Overall, 74% of the samples had therapeutic antipsychotic levels, 19% had subtherapeutic
concentrations, while supra-therapeutic concentrations were measured for clozapine
(7%). Therapeutic drug concentrations were recorded in 54% of plasma samples from patients
being under olanzapine medication and in all patients under long-acting injectables.
Sub-therapeutic levels were either attributed to non-adherence, or they reflected residual levels
due to medication changes. Supra-therapeutic levels were recorded for clozapine and were
not followed by adverse effects.

Conclusion:

This is the first study on antipsychotic plasma levels conducted in Greece. Our
results show the importance of performing measurement of plasma antipsychotics levels, at
appropriate time intervals, for improving adherence, clinical decision making and thus clinical
efficacy. Especially for FEPs, such approach could contribute to early detection of treatment
limitations and improve outcome.
Antibacterial Activity of Different Concentrations of Date Vinegar in Comparison to Ciprofloxacin against Multidrug-Resistance Pseudomonas aeruginosa Isolated from Infected Burn
Authors: Rabeea Ihsan S. , Janabi Ali M.H.
Published: June 2018

Background: Despite recent advances in burns management and antimicrobial chemotherapy,
infection continues to be a tricky in the burns. Treatment of a burn infection especially in case of
multi-drug resistant Pseudomonas aeruginosa is a big challenge in clinics and needs novel strategies.
Miscarriage of the current treatment strategies to control several cases of burns infections, the systemic
and local toxicity that are produced by many topical antibiotics (especially in children), and the delay of
healing caused by several antiseptics, make a strong motive to find effective and safe products.

Aim: This study aimed to investigate the in vitro activity of different concentration of date vinegar
against P. aeruginosa in comparison to the ciprofloxacin, one of the antibiotics used in the treatment of
burns infection by using disk diffusion method and agar dilution MICs assay.

Results and Conclusion: The disk diffusion method revealed that mean inhibition zone of date vinegar
at 100%, 50%, 20%, 10% and 5% were (50.9 ±0.27) mm, (30.5 ±0.24) mm, (25.9 ±0.29) mm,
(18.3±0.22) mm, and (9.2±0.25) mm respectively while ciprofloxacin has mean inhibition zone (8.95
±2.25) mm and MICs (1.25%). So the conclusion was that date vinegar exerted a good in vitro antimicrobial
activity against all tested isolates.
Low cost and comprehensive pork detection in processed food products with a different food matrix
Authors: Sugiana Fenny Aulia , Widyowati Henni , Warisman Muhammad Ali , Suryani Suryani , Desriani Desriani
Published: June 2018

The adulteration of processed beef-based meat products with pork is a sensitive issue in Indonesia. In this study, we developed a detection method for the low cost identification of pork in processed meat products. We used the cost-efficient Taq DNA polymerase, DreamTaq Green PCR master mix (2x), and duplex PCR method to recognize pork simultaneously with 18S rRNA detection. A positive control containing a pork gene inserted into pGEM®-T easy was prepared, along with a negative control. The results of the duplex PCR were used to assess its specificity, detection limit, and its ability to recognize pork in processed meat products with a different food matrix. 18S rRNA detection was for confirming DNA integrity of DNA extracted from the processed food, while the positive control confirmed that the reagents were working well and the negative control confirmed a non-contamination problem. Following this, the duplex PCR was optimized and the optimum concentration primer for duplex PCR detection was found to be 3 µm for pork and 0.2 µm for 18S rRNA. As little as 3.125 ng of the DNA template could be used to detect whether a sample contained pork. Duplex PCR is a simple, fast, sensitive, specific, and low cost method of detecting pork in processed meat products.
Coreocartografia: corpos, dança, pesquisa em psicologia
Authors: Galindo Dolores , Miliolli Daniele
Published: June 2018

Aliado ao interesse de trabalhar processos de criação em Dança Contemporânea como método de pesquisa em Psicologia, este texto discute um tipo de pesquisa onde o corpo de quem pesquisa é, ao mesmo tempo, pesquisado e pesquisador, o que chamamos de coreocartografia.
Acolhendo Dissonâncias: Por Uma Clínica Compositora no Cuidado De Si
Authors: Bento Lima Martha
Published: June 2018

Entre os anos 2011 e 2015 realizamos uma Oficina de Composição Musical com crianças e adolescentes na faixa etária compreendida entre 9 a 14 anos em um centro comunitário situado na favela do Morro dos Macacos, na cidade do Rio de Janeiro. Este ensaio traz um relato de experiência de intervenção realizada com os jovens durante esses anos em que a música serviu como um dispositivo de expansão e singularização da vida, permitindo a criação de práticas ético-estéticas pautadas por uma ética do Cuidado de Si. Tal relato oferecerá a paisagem sonora desafiadora em que estivemos implicados nos primeiros meses de realização da oficina na favela, problematizando as vivências, dificuldades e estratégias clínico-estéticas que procuramos desenvolver em uma realidade complexa, considerando alguns conceitos utilizados pela Filosofia da Diferença, pela psicanálise de Donald Winnicott e pela filosofia de Michel Foucault.
Pesquisa-Intervenção em Saúde Mental: Balançando as Redes da Saúde / Research-Intervention in Mental Health: Balancing Health Networks
Authors: Sivinski Tamires Da Cunha , Schenkel Júlia Monteiro
Published: June 2018

A implantação de redes de saúde proposta pelo Sistema Único de Saúde (SUS) tem-se dado com diferentes desafios, entre estes, destacamos a construção de um cuidado integral. Como contribuição a este debate nos propomos a discutir a circulação dos usuários do SUS na Rede de Atenção Psicossocial. Apresentamos resultados de uma pesquisa-intervenção participativa realizada de 2013 a 2015 na região metropolitana de Porto Alegre com usuários, trabalhadores e gestores ligados à Rede de Atenção Psicossocial, que pôde acompanhar as práticas de saúde mental na atenção básica. Questionamentos dos usuários acerca dos modos instituídos de encaminhamentos e quanto às possibilidades de vinculação aos serviços foram os eixos de reflexão deste artigo. Conclui que a constituição de uma Rede de Atenção Psicossocial articulada e integrada, tendo a Atenção Básica como ponto de referência requer a renovação de contratos e de vínculos para a produção afetiva e efetiva de cuidado integral. Palavras-chave: Cuidado Integral; Redes de Saúde; Atenção Básica; Saúde Mental.
A abordagem Open Dialogue: história, princípios e evidências / The Open Dialogue approach: history, principles and evidence
Authors: Florence Ana Carolina
Published: June 2018

A abordagem Open Dialogue foi desenvolvida na Finlândia na década de 1980, como um conjunto de práticas e princípios que modificou o modelo de atenção aos problemas de saúde mental da região. Através da proposta de reuniões familiares envolvendo a rede social das pessoas em crise em uma perspectiva dialógica, a abordagem Open Dialogue reduziu o número de internações em hospitais psiquiátricos e o tempo não tratado da doença; incorporou o uso seletivo de neurolépticos e promoveu taxas de recuperação de 84% das pessoas tratadas. O objetivo deste artigo é apresentar uma revisão narrativa da literatura sobre a abordagem Open Dialogue trazendo a história de seu desenvolvimento, os sete princípios que orientam suas práticas e estudos de efetividade. Por fim, convidamos o leitor ao debate de estratégias de cuidado aos primeiros episódios psicóticos, contando que a abordagem Open Dialogue possa oferecer pistas para a Atenção Psicossocial brasileira.Palavras-chave: Saúde Mental; Atenção Psicossocial; Open Dialogue.
Problematizando Conceitos em Saúde Pública, Vitalizando Cuidado de Pessoas com Necessidades Relacionadas ao Uso de Álcool e Outros Drogas / Problematising Concepts in Public Health, Vitalising Care for People with Needs Relative to the Use of Alcohol and Other Drugs
Authors: De Vasconcelos Michele De Freitas Faria , Melo Liliana Da Escóssia , Viana Maurício Mangueira , Machado Dagoberto De Oliveira , Martins João Sampaio
Published: June 2018

A partir de discussões desenvolvidas no interior de processos de pesquisa, formação, trabalho e intervenção com políticas públicas no Estado de Sergipe, este artigo tem por objetivo analisar/problematizar/vitalizar conceitos e noções que figuram no campo das práticas de saúde voltadas para o cuidado em álcool e outras drogas: saúde, droga, vulnerabilidade, inclusão/exclusão, redução de danos, cidadania, território. A intenção de analisar e problematizar conceitos tem o intuito, por um lado, de desencaminhar formas naturalizadas de planejar e produzir cuidado em álcool e outras drogas e, por outro, de vitalizar tal campo, na medida em que tais problematizações podem trazer consigo a força de ampliar sentidos e qualificar modos de intervenção, em vez de se traduzirem em práticas, discursivas e não discursivas, de ajuste, desqualificação e homogeneização do social.Palavras-chave: Políticas Públicas; Saúde Pública; Política Conceitual; Álcool e Outras Drogas.
PROBLEMS OF NOMADIC GOAT BREEDERS AND THEIR EFFECTS ON FOREST
Authors: KARAGÖL Eyyüp , KESKİN Mahmut
Published: June 2018

This study was carried out to evaluate the
relationship between goat breeders and forests with the perspectives of
breeders and forestry officers and to develop some solution proposals on the
issues expressed as problems. The material of the study was the forest guard
officers and forestry technicians who are the personnel of the
Sanlıurfa-Mardin-Diyarbakır Forestry Directorates and the families of the
nomadic people who stayed in Karacadağ and Karacurun areas in the province of
Viranşehir in Şanlıurfa. At least half of the nomadic families in the area and
all personnel working in the Forestry Management Department were surveyed. At
the end of the study it was reported that when the goat was grazed
uncontrollably it could be harmful to the areas where young trees were found
but it would be beneficial to the forest when grazing in areas with large
trees.
ENVIRONMENTAL EFFECT OF DELAY TIME IN OPEN PIT BLASTING
Authors: Deniz Vedat , Deniz Orçun Tugay
Published: June 2018

In this study, the effect on the ground
vibration values of two different surface delay times (17 ms and 25 ms) in
between holes in the blasting operations in the quarry belong to the Çorum
Votorantim Cement Corporation were investigated. The vibration measurements of
the blasting in both surface delay times have been taken from different
distances, and the relationship between the scale distance (SD) and the peak
particle velocity (PPV) was investigated. From the test results of the two
different surface delay times, not only have there been different results
obtained in the relationship between the scale distance and the peak particle
velocity but also different results on the frequency have been obtained, the
amplitude and the duration of the vibration.
RETRACTED: CAPILLARY REFILL TIME MEASUREMENT DEVICE
Authors: Bal Ufuk
Published: June 2018

Yükseköğretim Kurumları Bilimsel Araştırma ve Yayın Etiği Yönergesinin Madde 4/2-k uyarınca etik ihlal yapıldığına Dergi Kurulu olarak oy birliği ile karar verilen 10.22531/muglajsci.379126 DOI numaralı makale (Bal, U. (2018). “Capillary refill time measurement device”, Mugla Journal of Science and Technology, 4(1), 37-40.)” geri çekilmiştir.
Auto-inhibition effects in anodic oxidation of phenols for electrochemical waste-water purification
Authors: Al-Maznai H. , Conway B.E.
Published: June 2018

Removal or modification of noxious organic impurities in waste-waters is a
major challenge for environmental science. Pollutants such as phenols and
their derivatives, as well as PCBs, have attracted special attention. In
recent years, the possibilities of effecting direct electrocatalytic
oxidations at high-area electrodes such as supported Pt or RuO2 have been
investigated. However, in a number of cases, especially with phenolic
impurities, application of anodic oxidation fails to lead to continuous
Faradaic oxidation currents owing to the electrode surfaces becoming blocked
with polymeric oxidation products leading to auto-inhibition (?passivation?)
of the desired electrode process. Examples of such effects with phenols and
related compounds are examined comparatively in the present paper by means
of cyclic volatammetry and chronoamperometry.
Lead dioxide electrodes for high potential anodic processes
Authors: Amadelli Rossano , Velichenko A.B.
Published: June 2018

Doping of PbO2 by cations (Fe3+, Co2+ and Ni2+), by F- and by cations and F-
simultaneously is discussed as a way of improving the stability and
electrochemical activity in processes occurring at high potentials. Doping
allows the control of the amount of structural water in an oxide. Radiotracer
experiments showed that high electrodeposition current densities favour the
segregation of incorporated tritium (protons) at the surface. On the other
hand, fluorine doping results in a marked decrease in the amount of surface
oxygen species. The influence of doping with metal cations strongly depends
on the nature of the metal. Iron behaves like fluorine, while nickel causes
an accumulation of surface oxygen species. Doped PbO2 electrodes have quite
good activities for the electrogeneration of ozone. In particular, Fe and Co
doped PbO2 showed a current efficiency of 15-20%for this process. This result
is relevant to our recent studies on ?cathodic oxidation?, i.e., an ozone
mediated electrochemical method in which an O2 stream is used to sweep
theO2/O3 gas mixture produced at a PbO2 anode into the cathodic compartment
of the same electrochemical cell containing polluting species.
Health Care Spending on Diabetes in the U.S., 1996–2013
Authors: Squires Ellen , Duber Herbert , Campbell Madeline , Cao Jackie , Chapin Abigail , Horst Cody , Li Zhiyin , Matyasz Taylor , Reynolds Alex , Hirsch Irl B. , Dieleman Joseph L.
Published: June 2018

OBJECTIVE

Health care spending on diabetes in the U.S. has increased dramatically over the past several decades. This research describes health care spending on diabetes to quantify how that spending has changed from 1996 to 2013 and to determine what drivers are increasing spending.

RESEARCH DESIGN AND METHODS

Spending estimates were extracted from the Institute for Health Metrics and Evaluation’s Disease Expenditure 2013 database. Estimates were produced for each year from 1996 to 2013 for each of 38 age and sex groups and six types of care. Data on disease burden were extracted from the Global Burden of Disease 2016 study. We analyzed the drivers of spending by measuring the impact of population growth and aging and changes in diabetes prevalence, service utilization, and spending per encounter.

RESULTS

Spending on diabetes in the U.S. increased from $37 billion (95% uncertainty interval $32–$42 billion) in 1996 to $101 billion ($97–$107 billion) in 2013. The greatest amount of health care spending on diabetes in 2013 occurred in prescribed retail pharmaceuticals (57.6% [53.8–62.1%] of spending growth) followed by ambulatory care (23.5% [21.7–25.7%]). Between 1996 and 2013, pharmaceutical spending increased by 327.0% (222.9–456.6%). This increase can be attributed to changes in demography, increased disease prevalence, increased service utilization, and, especially, increases in spending per encounter, which increased pharmaceutical spending by 144.0% (87.3–197.3%) between 1996 and 2013.

CONCLUSIONS

Health care spending on diabetes in the U.S. has increased, and spending per encounter has been the biggest driver. This information can help policy makers who are attempting to control future spending on diabetes.
Effect of ultra-sonic peening on laser-arc hybrid welded NV E690 steel
Authors: Wang Z. D. , Lu Y. , Sun G. F. , Ni Z. H.
Published: June 2018

Hybrid laser-arc welding (HLAW) was carried out on 690 MPa high-strength NV E690 steel plates of 15 mm thickness using the double-pass welding process. Fine weld joints with good performance were successfully obtained by double-pass HLAW. Ultrasonic peening treatment (UPT) was performed on the welded seams to improve the microstructure and mechanical properties. Refined microstructure and reduced porosity ratio were introduced by UPT. Some porosity closed while some changed from circular into flat. Average residual stress changed from 301 to −426 MPa after UPT. Average micro-hardness changed from 350–375 HV to 420–430 HV. Tensile strength and bending strength were around 830 and 1759 MPa, respectively, close to those before UPT. Low-temperature (−40 °C) absorbed impact energy varied from 32 to 40 J, with 25% improvement. Refined microstructure contributed to the improvement of micro-hardness and mechanical properties. However, due to the limited thickness of the ultrasonic peened layer, the improvement of strength, which depended on the strength of the test material as a whole, was not obvious. Stress corrosion resistance of the ultrasonic peened weld was improved. Mechanism of the microstructure evolution and its relationship with the tensile, bending strength, low-temperature absorbed impact energy and stress corrosion resistance were discussed.
Investigations on remote laser beam welding of dissimilar joints of austenitic chromium-nickel steel (X5CrNi18-10) and aluminum alloy (AA6082-T6) for battery housings
Authors: Seffer Oliver , Springer André , Kaierle Stefan
Published: June 2018

Owing to the enormous potential of weight saving and the consequential reduction of pollutant emissions, the use of hybrid components made of steel and aluminum alloys is increasing steadily, particularly concerning automotive lightweight construction. Especially in the automotive industry, remote laser beam welding has been established as a suitable and efficient method for joining similar material for several years. In contrast to this, thermal joining of steel and aluminum alloys involves different metallurgical and technological challenges, due to the formation of hard and brittle intermetallic phases, which decrease the strength and the formability of the dissimilar joints. In this context, the results presented show investigations on remote laser beam welding for dissimilar lap joints of the austenitic chromium–nickel steel material X5CrNi18-10 and the precipitation hardening aluminum wrought alloy AA6082-T6. For example, lightweight battery housings for electromobility are potential applications for this technology. Among other things, the influence of the energy per unit length (welding speed) and the number of welding seams on the achievable strengths are analyzed. Characterization of the dissimilar joints includes the use of tensile shear tests, metallographic analyses, hardness tests, and elemental analyses, depending on the energy per unit length.