bluuebunny/crossref_metadata_2025 huggingface dataset:
A Generalized Dynamic Potential Energy Model for Multiagent Path Planning
Authors: He Liu , Xi Haoning , Guo Tangyi , Tang Kun
Published: July 2020

Path planning for the multiagent, which is generally based on the artificial potential energy field, reflects the decision-making process of pedestrian walking and has great importance on the field multiagent system. In this paper, after setting the spatial-temporal simulation environment with large cells and small time segments based on the disaggregation decision theory of the multiagent, we establish a generalized dynamic potential energy model (DPEM) for the multiagent through four steps: (1) construct the space energy field with the improved Dijkstra algorithm, and obtain the fitting functions to reflect the relationship between speed decline rate and space occupancy of the agent through empirical cross experiments. (2) Construct the delay potential energy field based on the judgement and psychological changes of the multiagent in the situations where the other pedestrians have occupied the bottleneck cell. (3) Construct the waiting potential energy field based on the characteristics of the multiagent, such as dissipation and enhancement. (4) Obtain the generalized dynamic potential energy field by superposing the space potential energy field, delay potential energy field, and waiting potential energy field all together. Moreover, a case study is conducted to verify the feasibility and effectiveness of the dynamic potential energy model. The results also indicate that each agent’s path planning decision such as forward, waiting, and detour in the multiagent system is related to their individual characters and environmental factors. Overall, this study could help improve the efficiency of pedestrian traffic, optimize the walking space, and improve the performance of pedestrians in the multiagent system.
Comparison of the CAMI-NSTEMI and GRACE Risk Model for Predicting In-Hospital Mortality in Chinese Non-ST-Segment Elevation Myocardial Infarction Patients
Authors: Wang Peng , Cong Hongliang , Zhang Ying , Liu Yujie
Published: July 2020

Introduction. The ability of risk models to predict in-hospital mortality and the influence on downstream therapeutic strategy has not been fully investigated in Chinese Non-ST-segment elevation myocardial infarction (NSTEMI) patients. Thus, we sought to validate and compare the performance of the Global Registry of Acute Coronary Events risk model (GRM) and China Acute Myocardial Infarction risk model (CRM) and investigate impacts of the two models on the selection of downstream therapeutic strategies among these patients. Methods. We identified 2587 consecutive patients with NSTEMI. The primary endpoint was in-hospital death. For each patient, the predicted mortality was calculated according to GRM and CRM, respectively. The area under the receiver operating characteristic curve (AUC), Hosmer–Lemeshow (H–L) test, and net reclassification improvement (NRI) were used to assess the performance of models. Results. In-hospital death occurred in 4.89% (126/2587) patients. Compared to GRM, CRM demonstrated a larger AUC (0.809 versus 0.752, p<0.0001), less discrepancy between observed and predicted mortality (H–L χ2: 22.71 for GRM, p=0.0038 and 10.25 for CRM, p=0.2479), and positive NRI (0.3311, p<0.0001), resulting in a significant change of downstream therapeutic strategy. Conclusion. In Chinese NSTEMI patients, the CRM provided a more accurate estimation for in-hospital mortality, and application of the CRM instead of the GRM changes the downstream therapeutic strategy remarkably.
Modelling and Solving Rescheduling Problems in Dynamic Permutation Flow Shop Environments
Authors: Valledor Pablo , Gomez Alberto , Priore Paolo , Puente Javier
Published: July 2020

The aim of this paper is to analyse, model, and solve the rescheduling problem in dynamic permutation flow shop environments while considering several criteria to optimize. Searching optimal solutions in multiobjective optimization problems may be difficult as these objectives are expressing different concepts and are not directly comparable. Thus, it is not possible to reduce the problem to a single-objective optimization, and a set of efficient (nondominated) solutions, a so-called Pareto front, must be found. Moreover, in manufacturing environments, disruptive changes usually emerge in scheduling problems, such as machine breakdowns or the arrival of new jobs, causing a need for fast schedule adaptation. In this paper, a mathematical model for this type of problem is proposed and a restarted iterated Pareto greedy (RIPG) metaheuristic is used to find the optimal Pareto front. To demonstrate the appropriateness of this approach, the algorithm is applied to a benchmark specifically designed in this study, considering three objective functions (makespan, total weighted tardiness, and steadiness) and three classes of disruptions (appearance of new jobs, machine faults, and changes in operational times). Experimental studies indicate the proposed approach can effectively solve rescheduling tasks in a multiobjective environment.
Dynamic and Static Nature of Br4σ(4c–6e) and Se2Br5σ(7c–10e) in the Selenanthrene System and Related Species Elucidated by QTAIM Dual Functional Analysis with QC Calculations
Authors: Hayashi Satoko , Nishide Taro , Nakanishi Waro
Published: July 2020

The nature of Br4σ(4c–6e) of the BBr-∗-ABr-∗-ABr-∗-BBr form is elucidated for SeC12H8(Br)SeBr---Br-Br---BrSe(Br)C12H8Se, the selenanthrene system, and the models with QTAIM dual functional analysis (QTAIM-DFA). Asterisks (∗) are employed to emphasize the existence of bond critical points on the interactions in question. Data from the fully optimized structure correspond to the static nature of interactions. In our treatment, data from the perturbed structures, around the fully optimized structure, are employed for the analysis, in addition to those from the fully optimized one, which represent the dynamic nature of interactions. The ABr-∗-ABr and ABr-∗-BBr interactions are predicted to have the CT-TBP (trigonal bipyramidal adduct formation through charge transfer) nature and the typical hydrogen bond nature, respectively. The nature of Se2Br5σ(7c–10e) is also clarified typically, employing an anionic model of [Br-Se(C4H4Se)-Br---Br---Br-Se(C4H4Se)-Br]−, the 1,4-diselenin system, rather than (BrSeC12H8)Br---Se---Br-Br---Br-Se(C12H8Se)-Br, the selenanthrene system.
Global Stability for a Semidiscrete Logistic System with Feedback Control
Authors: Xu Li , Lou Shanshan , Han Ruiwen
Published: July 2020

In this paper, a semidiscrete logistic model with the Dirichlet boundary conditions and feedback controls is proposed. By means of the sub- and supper-solution method and eigenvalue theory, the unique positive equilibrium is proved. By constructing a suitable Lyapunov function, the global asymptomatic stability of the unique positive equilibrium is investigated. Finally, numerical simulations are presented to verify the effectiveness of the main results.
Ileosigmoid Knotting: Analysis of Patients Clinical Profiles and Determinants of Outcomes
Authors: Abebe Kirubel , Sherefa Kalid , Teshome Henok , Abebe Engida
Published: July 2020

Introduction. Ileosigmoid knotting (ISK) is an uncommon form of bowel obstruction due to wrapping of the ileum or sigmoid colon around the base of the other. It is associated with poor prognosis. Data on ISK are scarce in our country. The aim of this study was to assess clinical profiles, management, and outcome of patients operated for ISK. Methodology. A retrospective analysis of all patients operated for ISK at St. Paul’s hospital millennium medical college (SPHMMC) from February 2014 to January 2020 was performed. Results. A total of 28 patients (M: F = 3 : 1) were studied. The mean age was 41.7 years (SD ± 19.5) and ranged from 18 to 80 years. The mean duration of illness was 1.6 days (SD ± 1.1). Abdominal pain and vomiting were seen in all patients followed by abdominal distention (24, 85.7%) and failure to pass feces or flatus (23, 82.1%). Preoperative diagnosis was correct in 6 (21.4%) patients. Almost all patients (26, 92.8%) had gangrenous bowel. The commonest procedure performed was resection of the gangrenous segments with primary ileoileal anastomosis and sigmoid end colostomy (16, 57.1%). Complications were seen in 11 (39.3%) patients and the commonest being surgical site infection (SSI) (7, 25%). Death occurred in 6 (21.4%) patients, and it was significantly (p=0.020) associated with intraoperative shock (systolic blood pressure (SBP) < 90 mmHg). Conclusion. ISK lacks specific clinical features and imposes a significant rate of bowel strangulation, which deserves high index of suspicion and urgent laparotomy. The choice of surgical procedure should be determined by intraoperative bowel status and patients’ general condition.
Efficacy and Safety of Wenxin Granules and Propafenone in Treatment of Atrial Premature Beats: A Systematic Review and Meta‐Analysis
Authors: Yuan Yi , Xiong Xing-jiang , Li Duo-duo , Li Hai-xia , Fu Jian-ping , Wu Hong-li
Published: July 2020

Objective. A meta‐analysis was conducted on the clinical efficacy and safety of Wenxin granules and propafenone for the therapy of atrial premature beats (APBs). Methods. A randomized controlled trial (RCT) of Wenxin granules and propafenone in the therapy of APB was systematically searched until June 1, 2019. Meta‐analysis was conducted with review manager (RevMan) 5.3. For the evaluation of methodological quality for randomized controlled trials, the Cochrane tool was used to assess the risk of bias. For the evaluation of the evidence quality, the online GRADEpro GDT was used. Results. Eleven RCTs with 1149 participants were included in this study. It has been identified that Wenxin granules combined with propafenone have better clinical efficacy than the use of propafenone alone in the treatment of APB (OR = 3.89, 95% CI (2.03, 7.44), P < 0.0001, low‐dose propafenone; OR = 4.24, 95% CI (1.32, 13.60), P = 0.02, high‐dose propafenone). There is no difference in clinical efficacy between the Wenxin granules alone and high‐dose propafenone in the treatment of APB (OR = 1.17, 95% CI (0.65, 2.11), P = 0.60), and Wenxin granules alone are superior to the low‐dose propafenone in the treatment of APB (OR = 2.56, 95% CI (1.34, 4.89), P = 0.004). Wenxin granules combined with propafenone can reduce the incidence of sinus bradycardia caused by propafenone (OR = 0.15, 95% CI (0.03, 0.70), P = 0.02). There was no significant difference between Wenxin granules combined with propafenone and propafenone alone in causing the atrioventricular block, dizziness, xerostomia, gastrointestinal symptoms, and tongue paresthesia. There was no significant difference between Wenxin granules alone and propafenone alone in causing dizziness, xerostomia, gastrointestinal symptoms, tongue paresthesia, frequent premature ventricular contractions, and prolongation of R‐R interval. Conclusion. Very low‐quality evidence showed that Wenxin granules may be superior to low‐dose propafenone in the treatment of APB. Wenxin granules may reduce the incidence of sinus bradycardia caused by propafenone. Limited by the quality of included RCTs, the conclusions of this study still need further verification.
Multiwideband Bandpass Filter Based on Folded Quad Cross-Stub Stepped Impedance Resonator
Authors: Wibisono Gunawan , Firmansyah Teguh , Herudin Herudin , Wildan Muh , Supriyanto Toto , Alaydrus Mudrik , Ujang Febrizal
Published: July 2020

A multiwideband bandpass filter (MW-BPF) using a quad cross-stub stepped impedance resonator (QC-SSIR) was simulated, fabricated, and measured. The proposed QC-SSIR is designed on a four-series arrangement of crossed open stub (COS) structures where each open stub is developed with a step impedance resonator (SIR) structure to generate a wide bandwidth. Compared to the COS resonator, the QC-SSIR has a wider fractional bandwidth and good transmission coefficients and is compact. ABCD matrix analysis is used to investigate the filter structure. Furthermore, the MW-BPF is designed on an FR4 microstrip substrate with εr = 4.4, thickness h = 1.6 mm, and tan δ = 0.0265. The results show that the proposed MW-BPF using a QC-SSIR achieves transmission coefficients/fractional bandwidths of −0.60 dB/49.3%, −1.49 dB/18.7%, and −1.93 dB/13.9% at 0.81 GHz, 1.71 GHz, and 2.58 GHz, respectively. Furthermore, to reduce the filter size, a folded QC-SSIR (FQC-SSIR) structure was also proposed. The results show that the proposed MW-BPF using an FQC-SSIR achieves transmission coefficients/fractional bandwidths of −0.57 dB/49.6%, −1.21 dB/17.7%, and −1.76 dB/12.5% at 0.82 GHz, 1.80 GHz, and 2.62 GHz, respectively. The size of the proposed MW-BPF using an FQC-SSIR is reduced by up to 46% compared with the MW-BPF using a QC-SSIR. Finally, the performance of the simulated MW-BPF based on the QC-SSIR and FQC-SSIR was in good agreement with the measurement results.
Anti-Diabetic Atherosclerosis by Inhibiting High Glucose-Induced Vascular Smooth Muscle Cell Proliferation via Pin1/BRD4 Pathway
Authors: Wu Yuansheng , Zhang Meijin , Xu Changsheng , Chai Dajun , Peng Feng , Lin Jinxiu
Published: July 2020

Background and purpose. Vascular smooth muscle cells (VSMC) proliferation and migration is the important pathological process of diabetic atherosclerosis. Bromine domain protein 4 (BRD4) is involved in cell proliferation and inflammatory disease. Pin1 enhances BRD4 stability and its transcriptional activity. This study aimed to explore the possible mechanism of Pin1/BRD4 in diabetic atherosclerosis. Methods. Diabetic Apoe-/- mice induced by streptozotocin were treated with vehicle, the Pin1 inhibitor juglone, or the BRD4 inhibitor JQ1 for 3 weeks. VSMCs were pretreated with juglone, JQ1, or vehicle for 45 min, and then exposed to high glucose for 48 h. Hematoxylin–eosin staining was performed to assess atherosclerotic plaques of the thoracic aorta. Western blotting was used to detect expression levels of Pin1, BRD4, cyclin D1, and matrix metalloproteinase-9 (MMP-9) in the thoracic aorta and VSMCs. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and transwell assay were used to measure proliferation and migration of VSMCs. Results. Juglone and JQ1 significantly improved atherosclerosis of diabetic Apoe-/- mice and reduced high glucose-induced VSMC proliferation and migration. Cyclin D1 and MMP-9 levels in the thoracic aorta were lower in diabetic Apoe-/- mice treated with juglone and JQ1 compared with vehicle-treated diabetic Apoe-/- mice. Additionally, BRD4 protein expression in high glucose-induced VSMCs was inhibited by juglone and JQ1. Upregulation of Pin1 expression by transduction of the Pin1 plasmid vector promoted BRD4 expression induced by high glucose, and stimulated proliferation and migration of VSMCs. Conclusions. Inhibition of Pin1/BRD4 pathway may improve diabetic atherosclerosis by inhibiting proliferation and migration of VSMCs.
Research on Model Predictive Control Method for Vehicle Lateral Stability Based on Hardware-in-the-Loop Test
Authors: Wang Jian , Liu Shifu , Wu Jian , Yang Jun , Li Aijuan
Published: July 2020

With the rapid development of the vehicle chassis control and autonomous driving technology, it is more and more urgent to realize the active steering technology of autonomous driving stability control. Under emergency conditions, the adhesion constraints, the model uncertainty, and the strong nonlinearity of vehicle bring great challenges to active steering control. In this paper, a model predictive control method for an active steering system based on a nonlinear vehicle model is proposed to solve the problems of adhesion constraint, model uncertainty, and external disturbance in the active steering system. Based on the real-time measurement of vehicle state, a new optimization method is proposed in this paper, which has good performance in dealing with the uncertainty and nonlinearity of the model. The control method transforms the constraint problem into quadratic programming and nonlinear programming. In order to ensure the control accuracy when the vehicle enters the nonlinear area, the control model is built with the combination of the nonlinear tire model and the 2DOF model. The control model is built based on Simulink, and the effectiveness of the controller is the verified joint simulation of Simulink and CarSim. The hardware-in-the-loop (HIL) test bench based on LabVIEW RT is built and tested in order to verify the feasibility and real effect of the controller. Simulation and HIL test results demonstrate that, compared with PID controller, the model predictive controller can accomplish the driving task well and improve the vehicle handling stability.
Silver Nanoparticle Production by Ruta graveolens and Testing Its Safety, Bioactivity, Immune Modulation, Anticancer, and Insecticidal Potentials
Authors: Ghramh Hamed A. , Ibrahim Essam H. , Kilnay Mona , Ahmad Zubair , Alhag Sadeq K. , Khan Khalid Ali , Taha Ramadan , Asiri Fawziah M.
Published: July 2020

Ruta graveolens, a plant belonging to the family Rutaceae, is traditionally used as a medicinal plant and a flavoring agent in food. This work aimed to prepare silver nanoparticles (AgNPs) using the ethanol extract from R. graveolens leaves and test different biological activities as well as insecticidal potentials in the extract and extract prepared AgNPs. Dried and powdered R. graveolens leaves were subjected to extraction using ethanol, and this extract was used to synthesize AgNPs. AgNP synthesis was monitored by the change in color, UV spectrophotometry, and electron microscopy (scanning). Fourier transform infrared (FT-IR) spectroscopy was used to monitor the functional groups in the extracts. Immunological, physiological, anticancer, antibacterial, and insecticidal potentials of the extract and its prepared AgNPs were tested. Results showed the ability of the leaf extract to synthesize. SEM examination revealed a spherical shape of AgNPs with a size of 40–45 nm. The extract contained many functional groups as indicated by FT-IR. The extract alone inhibited the growth of normal rat splenic cells, while the extract containing AgNPs stimulated its growth. Extract alone stimulated HeLa cell proliferation and inhibited HepG2 growth, while both cell line growth was inhibited by the extract containing AgNPs. Both the extract and extract with AgNPs were safe on RBCs and did not cause any severe elevation in liver enzymes. The extract alone and with AgNPs showed insecticidal activity against Culex pipiens. Our findings suggest that the R. graveolens leaf extract, alone or with AgNPs, is biologically safe on animal cells and has antibacterial, insecticidal, and immunomodulation potentials.
Downregulation of CyclophilinA/CD147 Axis Induces Cell Apoptosis and Inhibits Glioma Aggressiveness
Authors: Xu Shengchao , Hu Chi , Xiao Zhiqiang , Luo Chengke , Liu Zhixiong
Published: July 2020

Gliomas are the most common primary tumors in the brain with poor prognosis. Previous studies have detected high expression of Cyclophilin A (CyPA) and CD147, respectively, in glioma. However, the correlation between their expressions and glioma prognosis remains unclear. Here, we investigated the expression of CyPA and CD147 in different types of glioma and characterized their relationships with clinical features, prognosis, and cell proliferation. Results showed that CyPA and CD147 expressions were elevated in higher grade gliomas. Moreover, the knockdown of CyPA and CD147 by RNA interference significantly induced cell express apoptosis biomarkers such as Annexin V and inhibited proliferation biomarkers like EdU in glioma cells. In summary, our findings revealed that high expression of CyPA and CD147 correlated with glioma grades. Moreover, downregulation of the Cyclophilin A/CD147 axis induces cell apoptosis and inhibits glioma aggressiveness. Those indicating CyPA and CD147 could be used as both potential predictive biomarkers and a potential therapeutic target.
Horizontal Well Completion with Multiple Artificial Bottom Holes Improves Production Performance in Bottom Water Reservoir
Authors: Wang Haidong , Liu Yikun
Published: July 2020

The horizontal well completion with stinger is usually used to control the bottom water cone. Although the pressure profile and the inflow profile along the horizontal wellbore can be divided into two parts by the stinger, these profiles have not really flattened. In order to flatten the pressure distribution and inflow distribution further, it proposes a new technology. This new horizontal well has multiple artificial bottom holes (MABH) along the wellbore and it has application potential. In order to verify the effectiveness of MABH technology, a model of horizontal well completion with MABH was established, and the production performance of different water cone control technologies was analyzed: conventional horizontal well, stinger completion horizontal well, and MABH completion horizontal well. The results show that the MABH technology has more advantages than the stinger technology. The uniformity of pressure distribution of the 6-MABH horizontal well is 55% higher than that of the horizontal well with string technology, and the uniformity of inflow distribution is increased by 65.25%. At the same time, although the operation of MABH technology is very simple, it should follow a rule of MABH installation: the position of the first MABH should be set at 242.5 m from the heel hole of the horizontal wellbore, and the other interval is 92.4 m.
The Use of Oral Analgesics and Pain Self-Efficacy Are Independent Predictors of the Quality of Life of Individuals with Rheumatoid Arthritis
Authors: Hashimoto Akira , Sonohata Motoki , Mawatari Masaaki
Published: July 2020

Objectives. This study investigated the relationship between quality of life (QOL) and several factors, including pain assessments, in patients with rheumatoid arthritis (RA). Methods. This cross-sectional, single-center study enrolled 85 patients with RA. The variables investigated included demographic characteristics, the 28-joint disease activity score with C-reactive protein (DAS28-CRP), painDETECT questionnaire (PDQ), pain self-efficacy questionnaire (PSEQ), and pain catastrophizing scale (PCS). QOL was measured using the Japanese validated version of the European Quality of Life questionnaire with five dimensions and five levels (EQ-5D-5L). Results. The use of oral steroids and oral analgesics was significantly associated with low EQ-5D-5L scores (P<0.05). EQ-5D-5L score had a significant positive association with PSEQ (r = 0.414) and significant negative association with age, disease duration, DAS28-CRP, PDQ, and PCS (r = −0.217, −0.343, −0.217, −0.277, and −0.384, respectively). Multiple regression analysis showed that the use of oral analgesics and PSEQ were independent predictors of EQ-5D-5L score (β = -0.248, P<0.05 and β = 0.233, P<0.05). Conclusions. The use of oral analgesics by RA patients may influence their QOL, which, in turn, may affect their feelings of self-efficacy. Various pain management strategies, including surgical treatment, may be explored for the treatment of RA. Furthermore, the PSEQ may be a prominent part of the patient’s overall assessment.
Unusual Case of Anaplastic Large Cell Lymphoma Presenting as a Breast Mass in a Patient with no History of Breast Implants
Authors: Ivashkevich Yana , Chernov Yaroslav , Chinenov Denis , Shpot Evgeniy , Bessonov Alexander A. , Yoga Arthy , Lyapichev Kirill A. , Konoplev Sergej
Published: July 2020

Adenocarcinoma is the most common malignant neoplasm involving breast tissue. In contrast to carcinomas, the other types of malignant neoplasms involving the breast are relatively uncommon. One of the examples of this rare entity is lymphoma. Traditionally, non-Hodgkin lymphomas (NHL) involving the breast are divided into primary lymphoma of the breast and systemic lymphoma, although the distinction could be challenging. Most of NHL involving breast tissue have B cell origin; T cell NHL represents less than 20% of all lymphoma cases. Anaplastic large cell lymphomas (ALCL) involving the breast accounts for even lower percentage of cases. Similar to ALCL involving other sites, there are several main types of ALCL identified: primary cutaneous ALCL and systemic ALCL, which is subdivided into ALK positive and ALK negative subtypes. Relatively recently, an additional distinct subtype of ALK-negative ALCL was described, which is associated with textured breast implants and needs to be considered as a differential diagnosis if patient has a history of breast implants. Here, we report a case of ALCL presented as a breast mass without history of breast implant and discuss similar cases published in the literature.
An Improved Mask R-CNN Model for Multiorgan Segmentation
Authors: Shu Jian-Hua , Nian Fu-Dong , Yu Ming-Hui , Li Xu
Published: July 2020

Medical image segmentation is a key topic in image processing and computer vision. Existing literature mainly focuses on single-organ segmentation. However, since maximizing the concentration of radiotherapy drugs in the target area with protecting the surrounding organs is essential for making effective radiotherapy plan, multiorgan segmentation has won more and more attention. An improved Mask R-CNN (region-based convolutional neural network) model is proposed for multiorgan segmentation to aid esophageal radiation treatment. Due to the fact that organ boundaries may be fuzzy and organ shapes are various, original Mask R-CNN works well on natural image segmentation while leaves something to be desired on the multiorgan segmentation task. Addressing it, the advantages of this method are threefold: (1) a ROI (region of interest) generation method is presented in the RPN (region proposal network) which is able to utilize multiscale semantic features. (2) A prebackground classification subnetwork is integrated to the original mask generation branch to improve the precision of multiorgan segmentation. (3) 4341 CT images of 44 patients are collected and annotated to evaluate the proposed method. Additionally, extensive experiments on the collected dataset demonstrate that the proposed method can segment the heart, right lung, left lung, planning target volume (PTV), and clinical target volume (CTV) accurately and efficiently. Specifically, less than 5% of the cases were missed detection or false detection on the test set, which shows a great potential for real clinical usage.
Coordination Pattern of the Thigh, Pelvic, and Lumbar Movements during the Gait of Patients with Hip Osteoarthritis
Authors: Ibara Takuya , Anan Masaya , Karashima Ryosuke , Hada Kiyotaka , Shinkoda Koichi , Kawashima Mahito , Takahashi Makoto
Published: July 2020

There are limited reports on segment movement and their coordination pattern during gait in patients with hip osteoarthritis. To avoid the excessive stress toward the hip and relevant joints, it is important to investigate the coordination pattern between these segment movements, focusing on the time series data. This study aimed to quantify the coordination pattern of lumbar, pelvic, and thigh movements during gait in patients with hip osteoarthritis and in a control group. An inertial measurement unit was used to measure the lumbar, pelvic, and thigh angular velocities during gait of 11 patients with hip osteoarthritis and 11 controls. The vector coding technique was applied, and the coupling angle and the appearance rate of coordination pattern in each direction were calculated and compared with the control group. Compared with the control group, with respect to the lumbar/pelvic segment movements, the patients with hip osteoarthritis spent more rates in anti-phase and lower rates in in-phase lateral tilt movement. With respect to the pelvic/thigh segment movements, the patients with hip osteoarthritis spent more rates within the proximal- and in-phases for lateral tilt movement. Furthermore, patients with osteoarthritis spent lower rates in the distal-phase for anterior/posterior tilt and rotational movement. Patients with hip osteoarthritis could not move their pelvic and thigh segments separately, which indicates the stiffness of the hip joint. The rotational movement and lateral tilt movements, especially, were limited, which is known as Duchenne limp. To maintain the gait ability, it seems important to pay attention to these directional movements.
Rapid and Sensitive Method for Extraction of Plicosepalus acacia with Determination of Its Main Polyphenolic Compounds Using Validated HPLC
Authors: AlZain Mashail N. , Herqash Rashed N. , Almoqbil Abdulaziz N. , Mohammed Almarfadi Omer , Ibrahim Mansour N. , Ullah Riaz , Noman Omar M.
Published: July 2020

Matrix solid phase dispersion (MSPD) trailed by HPLC is a quick and fruitful technique utilized for fortitude of flavonoids such as Catechin, Kaempferol, Quercetin, and Rutin existing in P. acacia. The trial parameters that influenced the extraction potential (comprising the mass ratio of sample to the dispersant, nature of dispersant, and the nature of elution solvent and its volume) were examined and optimized. These MSPD optimized parameters regulated are as follows: 8 mL of methanol was utilized as elution solvent, silica gel/sample mass ration was selected to be 2 : 1, and dispersing sorbent was silica gel. The technique retrievals were regulated to be “from 96.87 to 100.54%” and the RSDs from 1.24 to 4.45%. The product of extract obtained by MSPD method was larger than that of other methods, i.e., sonication extraction or traditional reflux with lessened necessities on time, sample, and solvent.
Sex-Specific Association of Serum Uric Acid Level and Change in Hyperuricemia Status with Risk of Type 2 Diabetes Mellitus: A Large Cohort Study in China
Authors: Lou Yanmei , Qin Pei , Wang Changyi , Ma Jianping , Peng Xiaolin , Xu Shan , Chen Hongen , Zhao Dan , Wang Li , Liu Dechen , Li Yang , Zhao Ping , Han Dezhu , Hu Dongsheng , Hu Fulan
Published: July 2020

Background. Conflicting findings have been reported regarding the sex-specific association between serum uric acid (SUA) level and type 2 diabetes mellitus (T2DM) risk, and no study has explored the association between the change in hyperuricemia status and T2DM risk. The study was aimed at exploring the sex-specific association of baseline SUA and changes in hyperuricemia status with T2DM risk. Methods. We included 37,296 eligible adults without T2DM at the first examination who attended the baseline examination and at least one follow-up annual examination. Cox and logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs) with their 95% confidence intervals (CIs) for T2DM risk associated with baseline SUA and the change in hyperuricemia status, respectively. Results. During a median follow-up of 3.09 years, of 37,296 eligible adults, 2,263 developed T2DM. Compared with the first SUA quartile, higher quartiles were associated with an increased risk of T2DM in women (HR 1.78, 95% CI 1.17-2.71 for Q3 and 1.93, 1.27-2.93 for Q4; Ptrend<0.001) but not in men. Compared with women with a persistent normal SUA level at baseline and the last follow-up, T2DM risk increased significantly among those whose SUA status changed from normal at baseline to hyperuricemia at the last follow-up (OR 1.71, 95% CI 1.12-2.55) and those with persistent hyperuricemia at baseline and the last follow-up (OR 2.37, 95% CI 1.60-3.46). However, for men, a nonsignificant association was found between the change in hyperuricemia status and T2DM risk. Conclusions. Baseline SUA and the change in hyperuricemia status were associated with T2DM risk only among women. The findings suggest the importance of monitoring SUA levels and maintaining them within a normal range for preventing or reducing incident T2DM in Chinese women.
The RNA‐Binding Protein HuR in Digestive System Tumors
Authors: Song Xiaoqing , Shi Xin , Li Wenjuan , Zhang Fa , Cai Zhonglin
Published: July 2020

Human antigen R (HuR) is a member of the Hu family of RNA‐binding proteins. This molecule, which was first described in tumors nearly two decades ago, has recently received much attention in tumor‐related research because it regulates the expression of many tumor‐associated molecules through posttranscriptional regulatory mechanisms, thereby affecting biological characteristics. It is suggested that HuR might be a novel therapeutic target and a marker for therapeutic response and prognostic assessment. Increasing evidence supports that HuR also plays critical roles in the development, therapy, and prognosis of digestive system tumors. Herein, we review the relationships between HuR and digestive system tumors, demonstrating the importance of HuR in digestive system tumor diagnosis.
Experimental Investigation of the Crater Caused by Hypervelocity Rod Projectile Impacting on Rocks
Authors: Qiu Yanyu , Yue Songlin , Wang Mingyang , Li Gan , Cheng Yihao , Zhao Zhangyong , Zhang Zhongwei
Published: July 2020

To investigate the cratering effects of hypervelocity rod projectile impacting on rocks, a two-stage light gas gun was used to carry out 10 groups of small-scale experiments, whose velocity ranges from 1.5 km/s to 4.1 km/s. After each experiment, the morphology and size of the hypervelocity impacting crater were accurately obtained by using a device for image scanning. According to the morphology of the final crater, the impact crater can be divided into crushing area, spallation area, and radial crack area. Based on the experimental results of steel projectile vertical impacting on granite targets, the relationship between the depth and the diameter of the crater is analyzed, i.e., h/D≈0.1∼0.2; it shows that the depth of the crater is much smaller than the diameter of the crater, and the crater seems to be a shallow dish. The relation between the kinetic energy of the projectile and the size of the crater was discussed. With the increase of the projectile kinetic energy, it is uncertain whether the depth of the crater increases, but the volume of the crater will increase. Lastly, dimensionless analysis of the impact crater was carried out. Specifically, the limitations of point source solutions to hypervelocity rod projectile impact cratering have been proved, and there is no essential difference to calculate the final crater by using the energy scale or the momentum scale.
PD-L1 Protein Expression on Both Tumor Cells and Macrophages are Associated with Response to Neoadjuvant Durvalumab with Chemotherapy in Triple-negative Breast Cancer
Authors: Ahmed Fahad Shabbir , Gaule Patricia , McGuire John , Patel Katir , Blenman Kim , Pusztai Lajos , Rimm David L.
Published: July 2020

Purpose:

In both the IMpassion 130 trial in the metastatic setting and in Keynote 522 in the neoadjuvant setting, patients with triple-negative breast cancer (TNBC) showed benefit from PD-1 axis immunotherapy. Here, we assess PD-L1 expression on both tumor and immune cells using quantitative immunofluorescence to assess association with benefit from neoadjuvant durvalumab concurrent with chemotherapy in TNBC.

Experimental Design:

Pretreatment core needle biopsies (n = 69) were obtained from patients who participated in a phase I/II clinical trial (NCT02489448). The final analysis included 45 patients [pathologic complete response (pCR) = 18, non-pCR = 27] due to technical issues and insufficient tissue. Slides were stained using a previously validated Ultivue DNA-based Ultimapper kit (CD8, CD68, PD-L1, Cytokeratin/Sox10, and Hoechst counterstain). The PD-L1 expression was analyzed by molecular compartmentalization without segmentation using AQUA software (version 3.2.2.1) in three tissue compartments including tumor (cytokeratin-positive cells), CD68+ cells, and overall stroma.

Results:

In patients with pCR, PD-L1 expression was significantly higher in tumor cells, in CD68+ cells and in the stroma compared with patients non-pCR. There was no difference in the amount of CD68+ cells in the tumor or stromal compartments between cases with pCR and non-pCR.

Conclusions:

Expression of PD-L1 in tumor cells, immune cells in stroma, and colocalized with CD68+ cells is associated with higher rates of pCR to durvalumab and chemotherapy in TNBC.
The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer
Authors: Schoenfeld Adam J. , Bandlamudi Chai , Lavery Jessica A. , Montecalvo Joseph , Namakydoust Azadeh , Rizvi Hira , Egger Jacklynn , Concepcion Carla P. , Paul Sonal , Arcila Maria E. , Daneshbod Yahya , Chang Jason , Sauter Jennifer L. , Beras Amanda , Ladanyi Marc , Jacks Tyler , Rudin Charles M. , Taylor Barry S. , Donoghue Mark T.A. , Heller Glenn , Hellmann Matthew D. , Rekhtman Natasha , Riely Gregory J.
Published: July 2020

Purpose:

SMARCA4 mutations are among the most common recurrent alterations in non–small cell lung cancer (NSCLC), but the relationship to other genomic abnormalities and clinical impact has not been established.

Experimental Design:

To characterize SMARCA4 alterations in NSCLC, we analyzed the genomic, protein expression, and clinical outcome data of patients with SMARCA4 alterations treated at Memorial Sloan Kettering.

Results:

In 4,813 tumors from patients with NSCLC, we identified 8% (n = 407) of patients with SMARCA4-mutant lung cancer. We describe two categories of SMARCA4 mutations: class 1 mutations (truncating mutations, fusions, and homozygous deletion) and class 2 mutations (missense mutations). Protein expression loss was associated with class 1 mutation (81% vs. 0%, P < 0.001). Both classes of mutation co-occurred more frequently with KRAS, STK11, and KEAP1 mutations compared with SMARCA4 wild-type tumors (P < 0.001). In patients with metastatic NSCLC, SMARCA4 alterations were associated with shorter overall survival, with class 1 alterations associated with shortest survival times (P < 0.001). Conversely, we found that treatment with immune checkpoint inhibitors (ICI) was associated with improved outcomes in patients with SMARCA4-mutant tumors (P = 0.01), with class 1 mutations having the best response to ICIs (P = 0.027).

Conclusions:

SMARCA4 alterations can be divided into two clinically relevant genomic classes associated with differential protein expression as well as distinct prognostic and treatment implications. Both classes co-occur with KEAP1, STK11, and KRAS mutations, but individually represent independent predictors of poor prognosis. Despite association with poor outcomes, SMARCA4-mutant lung cancers may be more sensitive to immunotherapy.
Evaluation of Clinical Features and Stroke Etiology in Patients with Bilateral Middle Cerebellar Peduncle Infarction
Authors: Zhou Chenguang , Fan Haixia , Chen Hao , Wang Haoyue , Li Zuopeng , Xu Ning , Sun Ruonan , Zhu Yinghui , He Yuanhong
Published: July 2020

Objective: The aim of this study was to characterize clinical features, etiologies, and mechanisms of strokes due to bilateral middle cerebellar peduncle infarction (BMCPI). Methods: Cases diagnosed as BMCPI in our hospital were retrieved, and a literature review was performed. Data on clinical features and brain MRI were obtained. Extracranial and intracranial segments of the vertebrobasilar artery were assessed by using digital subtraction angiography, magnetic resonance angiography, or computed tomography angiography. Results: Thirteen cases (11 men and 2 women) of BMCPI were identified. A high-intensity signal of diffusion-weighted imaging sequence involving the bilateral middle cerebellar peduncle was observed in all patients. Most patients experienced vertigo, dysarthria, ataxia, and hearing disorders. Eleven of these cases were classified as large artery atherosclerosis, one as traumatic vertebral artery (VA) dissection, and one as giant cell arteritis. Conclusion: BMCPI is a rare cerebrovascular disease characterized by vertigo, ataxia, and dysarthria, which may also be accompanied by a hearing deficit or clinical signs of brainstem damage. BMCPI may be associated with hypoperfusion secondary to occlusive disease of the bilateral VA or proximal basilar artery.
Ablation of Atrial Fibrillation Without Left Atrial Appendage Imaging in Patients Treated With Direct Oral Anticoagulants
Authors: Diab Mohamed , Wazni Oussama M. , Saliba Walid I. , Tarakji Khaldoun G. , Ballout Jad A. , Hutt Erika , Rickard John , Baranowski Bryan , Tchou Patrick , Bhargava Mandeep , Chung Mina , Varma Niraj , Martin David O. , Dresing Thomas , Callahan Thomas , Cantillon Daniel , Kanj Mohamed , Hussein Ayman A.
Published: July 2020

Background:

Many centers continue to routinely perform transesophageal echocardiograms before atrial fibrillation (AF) ablation procedures in patients treated with direct oral anticoagulants (DOACs). One study suggested that the procedures could be done without transesophageal echocardiogram but used intracardiac echocardiography imaging of the appendage from the right ventricular outflow. This study aimed to assess the safety of ablation for AF without transesophageal echocardiogram screening or intracardiac echocardiography imaging of the appendage in DOAC compliant patients.

Methods:

All patients undergoing AF ablation at the Cleveland Clinic (2011–2018) were enrolled in a prospectively maintained data registry. All consecutive patients presenting with AF or atrial flutter on DOAC were included. Periprocedural thromboembolic complications were assessed.

Results:

A total of 900 patients were included. Their median CHA
2
DS
2
-VASc score was 2 (interquartile range 1–3). All were on DOACs (333 rivaroxaban, 285 dabigatran, 281 apixaban, and 1 edoxaban). Thromboembolic complications occurred in 4 patients (0.3%): 2 ischemic strokes, 1 transient ischemic attack without residual deficit, and 1 splenic infarct; all with no further complications. Bleeding complications occurred in 5 patients (0.4%): 2 pericardial effusions (1 intraoperative, 1 after 30 days, both drained), 3 groin hematomas (1 of them due to needing heparin for venous thrombosis, none required interventions). No patients required emergent surgeries.

Conclusions:

In DOAC compliant patients who present for ablation in AF/atrial flutter, the procedures could be performed without transesophageal echocardiogram screening or intracardiac echocardiography imaging of the appendage; with low risk of complications.
Incidence and Predictors of Very Late Recurrence of Atrial Fibrillation Following Cryoballoon Pulmonary Vein Isolation
Authors: Musat Dan L. , Milstein Nicolle S. , Bhatt Advay , Sichrovsky Tina C. , Preminger Mark W. , Pistilli Carissa , Rozylowicz Michael , Shaw Richard E. , Mittal Suneet
Published: July 2020

Background:

A very late recurrence (VLR) of atrial fibrillation (AF) is considered present when the first recurrence of AF occurs ≥12 months following ablation. Prior studies characterizing VLR have not used an implantable loop recorder for ECG monitoring. Thus, it is unknown whether VLR truly occurs or whether these patients have simply had unrecognized AF. Our objective was to assess the incidence and predictors of VLR in patients who underwent cryoballoon pulmonary vein isolation alone, had an implantable loop recorder, and were confirmed AF free for at least 1 year.

Methods:

We enrolled consecutive patients with paroxysmal or persistent AF who underwent cryoballoon pulmonary vein isolation and had an implantable loop recorder implanted <3 months post-ablation. Patients free of AF 1 year post-ablation were followed prospectively for recurrent AF. All AF episodes were adjudicated.

Results:

We included 188 patients (66±10 years; 116 [62%] men; 102 [54%] paroxysmal AF; CHA
2
DS
2
-VASc, 2.6±1.7). After 1 year post-pulmonary vein isolation, 93 (49%) patients remained AF free. During subsequent follow-up, 30 (32%) patients had VLR of AF. The only independent risk factor for VLR was an elevated CHA
2
DS
2
-VASc score (hazard ratio, 1.317 [95% CI, 1.033–1.6979];
P
=0.026). Patients with CHA
2
DS
2
-VASc score ≥4 represented a quarter of the population and were at the highest risk.

Conclusions:

Our data using implantable loop recorders for continuous ECG monitoring post-AF ablation show that VLR occurs in a third of patients after an apparently successful cryoballoon pulmonary vein isolation procedure. Additional strategies are needed to ensure long-term freedom from AF recurrences in these high-risk patients.
Positive and synergistic effects of oxytetracycline and β-glucan on non-specific immune responses in the white shrimp, Litopenaeus vannamei (Boone, 1931) (Dendrobranchiata, Penaeidae)
Authors: Lee Po-Tsang , Wu Yu-Sheng , Chen Hsiang-Yin , Liao Zhen-Hao , Huang Huai-Ting , Chen Yu-Chun , Nan Fan-Hua
Published: July 2020

This study was to examine the immunomodulatory effects of oxytetracycline (OTC) on the white shrimp Litopenaeus vannamei (Boone, 1931). Immune parameters were not suppressed by OTC treatment in haemocytes in vitro. A total of 96 healthy shrimp were divided into four groups. Group 1 was the control group. Group 2 received 50 mg OTC/kg body weight/day. Group 3 received 1 g β-glucan/kg feed. Group 4 received 50 mg OTC/kg body weight/day and 1 g/kg β-glucan. OTC residues were more highly accumulated in the hepatopancreas than in muscle tissue during the rearing period, and the addition of β-glucan prolonged the retention time of OTC in the muscle tissue. Additionally, dietary administration of OTC in combination with β-glucan facilitated the excretion of OTC from the hepatopancreas. Shrimp that orally ingested OTC alone had an elevated total haemocyte count, phagocytosis, superoxide anion production and prophenoloxidase activity, and these immunostimulatory effects were further enhanced in shrimp receiving OTC in combination.
Flexibility and Sharīʿah Compliance of Islamic Financial Contracts: An Evaluative Framework
Authors: Moqbel Tareq , Ahmed Habib
Published: July 2020

Although the key distinguishing feature of Islamic finance is compliance with Sharīʿah, there is criticism from various quarters on the Sharīʿah compliance of its products. However, there is no objective way to assess the Sharīʿah compliance of Islamic financial contracts. This article develops a structured framework for analysing Sharīʿah compliance of Islamic financial contracts by deconstructing them and developing principles of evaluation based on concepts from Islamic legal theory. Other than providing a framework to assess Sharīʿah compliance of Islamic financial contracts, this article also alludes to an important issue regarding the contracts’ flexibility. Using concepts from Islamic legal theory, the article classifies different contractual stipulations according to their legal weight, and identifies how legal perspectives on the requirements of compliance can determine the flexibility of contracts. An evaluative framework is used to assess the Sharīʿah compliance of an actual muḍārabah (silent partnership) contract and finds it to be defective.
Evaluation of Ethical Review and Oversight Processes by AAALAC International
Authors: Guillén Javier , Borkowski Gary L.
Published: July 2020

AAALAC International is a nonprofit organization that evaluates and accredits research, testing and educational animal care and use programs around the world. The ethical review and oversight processes are key elements of a program, and therefore are thoroughly assessed during the accreditation process. Legal approaches to ethical review and oversight vary across geopolitical areas and are nonexistent in some regions, creating a heterogeneous landscape of processes globally. In AAALAC’s interpretation, ethical and oversight processes must first comply with applicable legislation (engineering standards), but also they must be effective (performance standards). To evaluate the efficacy of each system and be consistent in the assessments, AAALAC relies on a performance-based approach which focuses on the outcome of the process, as AAALAC considers that the same satisfactory outcome can be achieved by different procedures. How AAALAC assesses the combination of legal compliance and the efficacy of ethical review and oversight processes in the international context is described.