bluuebunny/crossref_metadata_2025 huggingface dataset:
Curriculum 2013, Physical Fitness, SMA Malemputra Aceh Besar
Authors: Fauzi Irwandi , Armaidi Armaidi
Published: April 2023

development and assessment of learning processes based on the 2013 Curriculum to improve the physical fitness of high school students. The 2013 curriculum emphasizes a competency-based learning approach that enables students to develop the knowledge, skills, and attitudes necessary to succeed in life. In terms of physical fitness, students need knowledge of the importance of maintaining physical health and fitness, as well as skills in performing effective physical activity. The first step in implementing the development and assessment of the learning process based on the 2013 Curriculum to improve the physical fitness of high school students is to adjust the curriculum to the needs of students. This is important because students have different needs in terms of physical activity and physical fitness. The curriculum should include sports and health-related competencies relevant to the student's needs.
Upaya Meningkatkan Keterampilan Passing Sepak Bola dengan Gaya Mengajar Cooperative Learning
Authors: Nanag Nanang
Published: April 2023

This study aims to Improve Football Passing Skills with Teaching Style Cooperative Learning in Grade VII A Students of SMP Negeri 1 Sanggau Ledo, Bengkayang Regency. The method used in this research is descriptive method, while the type of research is classroom action research. The research tool used is the Attitude Process, Observation Sheet. Sources of data in this study were teachers and students, research data in the form of findings during observations from the work of students that had been collected. Then processed qualitatively, this data analysis was carried out in a quantitative descriptive manner based on the results of observations of activities and learning outcomes. The results showed that from Pracyclus 34.48%, Cycle I 68.96% and Cycle II 86.20%. The minimum completeness criterion is 75. So it can be interpreted that there is an increase in football passing skills with a cooperative learning teaching style in class VII A students at SMP Negeri 1 Sanggau Ledo, Bengkayang Regency.
Relay-cropping soybean-maize in saturated soil culture increases efficiency of land use and nitrogen fertilizer
Authors: Suntari  , Ghulamahdi Munif , Maya Melati
Published: April 2023

Relay-cropping in saturated soil cultivation could increase land efficiency, but its effect on land use and nitrogen fertilizer efficiency is unclear. The research objective was to evaluate the land productivity of the relay-cropping system by calculating the land equivalent ratio (LER) and the effectiveness of nitrogen fertilizer, and by determining the effect of previous soybean biomass. The experiment was arranged in a three-factor randomized complete block design. The first factor was the cropping patterns of soybean and maize, i.e., relay-cropping soybean-maize and maize monoculture. The second factor was the maize varieties, i.e., Pioneer 27 and Sukmaraga. The third factor was the application of N fertilizer with 4 doses: 0, 50, 100, and 150 kg ha-1. The results showed that the application of soybean biomass increased maize yield by 7.24%. Pioneer 27 produced a higher yield than Sukmaraga, and the dose of N fertilizer of 150 kg ha-1 resulted in the highest yield of 7.50 tons ha-1. The highest LER of 2.18% was achieved in the relay-cropping without applying follow-up N fertilizer (control). The experiment concludes relay-cropping after soybean save land by about 118% and save N fertilizer by 33.3%. The reduction of N fertilizer application by 33.3% (100 kg N ha-1) reduced corn cob productivity by 13.3%, and is not significantly different from 150 kg N ha-1.     

Keywords: chlorophyll, LER, plant residue
Exploring the spatio-temporal patterns of road traffic accidents in Saudi Arabia
Authors: Alhusain Faisal , Alghafees Mohammad , Rezk Ahmed , Alwatban Saud , Almoaiqel Faisal , Alsalamah Majid
Published: April 2023

Background: Road traffic accidents (RTAs) are a leading cause of mortality and morbidity in the young population and are a growing problem worldwide. This study is a comprehensive analysis of the spatiotemporal patterns of 352,464 RTAs in Saudi Arabia from 2017 to 2018.
Methods: This study consists of three principal phases of analysis (exploratory data analysis of the RTA dataset by analyzing population involvement in RTAs and mortality or morbidity, we examined the geographic and temporal distribution of RTA, and we performed a spatial hotspot analysis per region on a monthly basis using local Moran's I hotspot clustering). This study presented the monthly spatiotemporal patterns of RTAs in Saudi Arabia in 1439 Hijri and data were obtained from the Saudi Open Data Portal for all.
Results: Four cities, Ar Riyad, Ash Sharqiyah, Makkah, and Jeddah, were in the top 25% of RTA involvement, mortality, and morbidity in Saudi Arabia. Four cities, Ar Riyad, Ash Sharqiyah, Makkah, and Jeddah, were in the top 25% of RTA involvement, mortality, and morbidity in Saudi Arabia. There were 11 injuries and 2 deaths per 100 accidents during the study period. More than 84% and 88% of those who were injured and killed in RTAs were male, respectively. There was a significant decrease in the number of RTAs in the last months of the year (Hajj month in the Hijri calendar) compared to other months in the Makkah region and the Eastern Province. In addition, no significant temporal patterns in daily occurrence rates at the national level. Similarly, there was no significant difference between RTA incidence on weekdays and weekends. Differences between daytime and nighttime were significant, with more accidents occurring during the day. The number of injuries per 1,000 population is the same throughout the year in the provinces of the country.
Conclusion: This study identified areas in Saudi Arabia where further investigation is needed to analyze the points that lead to more RTAs and consequently more disabilities and mortalities.
THE EFFECT OF DELIVERY MODE ON NT-PROBNP LEVELS IN NEWBORNS
Authors: KABA İlknur , ALİEFENDİOĞLU Didem
Published: April 2023

Objective: Reference values of NT-proBNP levels in newborns may vary depending on gestational age, postnatal age and Apgar scores. However, the effect of the mode of delivery has been less investigated, and the results are contradictory. In this study, it was aimed to compare NT-proBNP levels in healthy term newborns born through vaginal delivery and cesarean (C/S) and to investigate whether delivery method had an effect on it.

Material and Methods: Healthy newborns born in our hospital and with a gestational age of ≥38 weeks were included in the study. Cases (n=56) were grouped according to delivery type. Both groups were similar in terms of gender, gestational age, body weight and Apgar scores. NT-proBNP levels, hematological parameters, LDH and CPK levels were studied in blood samples taken in the first hours after birth. The two groups were compared in terms of these parameters and it was investigated whether there was a relationship between the parameters.

Results: NT-proBNP levels were 3145 (372-7231) pg/ml in newborns born vaginally and 783 (401-6563) pg/ml in newborns born by cesarean section (p
İNDİREKT KAROTİKOKAVERNÖZ FİSTÜLE BAĞLI SEKONDER GLOKOM
Authors: DİNÇ Damla Nur , DOĞAN Aysun Şanal
Published: April 2023

68 yaşındaki kadın hasta sağ gözünde çeşitli damlalara rağmen 1 yıldır devam eden kızarıklık şikayetiyle başvurdu. Hasta 10 yıldır hipertansiyon tedavisindeydi. Travma öyküsü yoktu. Görme keskinliği bilateral tamdı. Biyomikroskopik muayenesinde sağda episkleral damarlar belirgindi.Pupiller izokorikti, proptozis yoktu, göz hareketleri ve renkli görme normaldi. Göz içi basıncı 24 /14 mmHg idi. Gonyoskopi bulgusu D30f1+ idi. Fundusta evre 2 hipertansif retinopati mevcuttu. Yapılan görme alanı ve optik koherans tomografi (OKT) tetkikleri normaldi. Hastadan inflamatuar patolojiler ve karotikokavernöz fistülü dışlamak için MRG ve MRG anjiyografi istendi. İnternal karotid arterin ince menengial dallarından sağ kavernöz sinüs doluşu izlendi. İndirekt karotikokavernöz fistül tanısı ile girişimsel radyoloji tarafından endovasküler tedavi yapıldı. Hastaya sekonder oküler hipertansiyon tanısıyla brimonidin 2X1 tedavisi verildi. Bulgularının düzelmesiyle 6 ay sonunda tedavisi kesildi. Takiplerine gelmeyen hastanın 7 yıl sonraki kontrolünde sağda azalmakla birlikte kızarıklığının devam ettiği, göz içi basıncının 18/10 mmHg olduğu görüldü. OKT sinir lifi analizinde inferiorda incelme izlendi. Görme alanında kör noktada genişleme ve seidel skotomuna gidiş nedeniyle sekonder glokom açısından topikal tedavi başlandı.Fistül tedavisi sonrasında glokom beklenmemektedir. Aktif dönemde glokom bulgusu olmayan hastanın 7 yıl sonra tek gözünde glokom gelişmiştir. Bu hastalar endovasküler tedavi sonrası da glokom açısından düzenli takip edilmelidir.
4-YEAR-OLD CASE WAS ADMITTED TO HOSPITAL WITH DELIRIUM CAUSED BY DEHYDRATION AND METABOLIC ACIDOSIS
Authors: ÖZCAN Eda Gül , KAYMAZ Nazan , AYLANÇ Hakan , BATTAL Fatih , KURTULUŞ Şenay
Published: April 2023

Delirium, a potentially reversible, acute-onset organic brain syndrome, is a behavioral manifestation of acute brain dysfunction associated with underlying medical conditions. It presents as marked and inconsistent mental changes characterized by dysregulated states of focus and cognition. It can be caused by several different causes, including infections, drugs, toxins, metabolic disorders, and a number of other medical conditions. This case report presents a 4-year-old girl with short bowel syndrome, who developed hyperactive delirium due to acute metabolic acidosis.
OTOİMMÜN HEPATİT TANISI KONULAN ÇOCUKLARDA TANI ANINDAKİ DEMOGRAFİK, KLİNİK, LABORATUVAR, RADYOLOJİK, HİSTOPATOLOJİK BULGULARIN VE TEDAVİNİN TEK MERKEZ DENEYİMİ
Authors: ERGANİ Anna Carina , GÜMÜŞ Meltem , KÖREZ Muslu Kazım , EMİROĞLU Halil Haldun
Published: April 2023

Amaç: Otoimmün hepatit (OİH) tanılı çocuk hastaların tanı sırasındaki demografik, klinik, laboratuvar ve histopatolojik verilerini, tedavi ve tedaviye yanıt oranlarını değerlendirme amaçlanmıştır.

Gereç ve Yöntemler: Merkezimizde son 10 yılda OİH tanısı konulan hastaların verileri retrospektif olarak incelendi.

Bulgular: Çalışmaya alınan 27 hastanın 19’u kız, 8’i erkekti. Ortalama tanı yaşı 10.89 ± 4.5 yıldı ve 3’ü Suriye uyrukluydu. Dokuz hastada ekstrahepatik hastalıklar mevcuttu. Klinik prezentasyon en sık akut hepatit olup, 24 hastaya Tip 1 OİH ve 3 hastaya seronegatif OİH tanısı konuldu. En fazla başvuru sebebi sarılık ve halsizlikti. Fizik muayenelerinde en sık hepatomegali ve palmar eritem gözlendi. Tanı anında 23 hastanın Ig G’si 2 katından yüksek ve ANA pozitifti. İki hastanın AMA ve 1 hastanın anti-SMA pozitifti. Karaciğer biyopsisinde en sık olarak 23 hastada arayüz hepatiti ve 20 hastada lenfoplazmositik infiltrasyon saptandı. İki hastanın manyetik rezonans kolanjiopankreatografisinde sklerozan kolanjit bulguları gözlendi. Birinci basamak tedavi rejimi başlanan 23 hastada tam klinik yanıt görülürken; 1 hastada kısmı yanıt ve 3 hasta yanıtsızdı. Yedi hastada tedavi yanıtsızlığı ve/veya ilaç sonrası yan etki nedeniyle tedavi değişikliği yapıldı. İki hastada kortikosteroid monoterapisi tercih edilir iken beş hastada takrolimus kullanıldı.

Sonuç: OİH’nin çocukluk çağındaki başvuru şekli ve süresinin değişkenliği sebebiyle karaciğer hastalığı bulguları ile başvuran çocuklarda OİH’den de şüphelenilmelidir. Çocuklarda nadir görülen bu hastalığın tanı kriterleri, tedavi rejimleri ve ikinci basamak tedavi ajanları konusunda daha fazla sayıda hasta içeren çalışmalara ihtiyaç vardır.
SEPTORİNOPLASTİ YAPILAN HASTALARDA SPREADER GREFT KONULMASININ AMELİYATIN FONKSİYONEL VE ESTETİK SONUÇLARI ÜZERİNE ETKİSİ
Authors: KANDEMİR Süheyla , PAMUK Ahmet Erim
Published: April 2023

Amaç: Spreader greft konularak ve konulmadan septorinoplasti ameliyatı yapılan hastalarda, ameliyatın fonksiyonel ve estetik sonuçlarının karşılaştırılması amaçlanmıştır.

Gereç ve Yöntemler: Çalışmada, 2018-2022 tarihleri arasında septorinoplasti ameliyatı yapılan 52 hasta retrospektif olarak incelendi. Hastalar spreader greft konulanlar (Grup 1, n=30) ve spreader greft konulmayanlar (Grup 2, n=22) olmak üzere iki gruba ayrıldı. Hastaların fonksiyonel ve estetik sonuçları ameliyat öncesi ve ameliyat sonrası burun tıkanıklığı semptom değerlendirme ölçeği (NOSE), sinonazal sonuç testi-22 (SNOT-22) ve yüz görünümünden memnuniyet (FACE-Q) ölçeği ile değerlendirildi.

Bulgular: Gruplar arasında yaş ve cinsiyet açısından anlamlı bir farklılık saptanmadı. Her iki grupta da ameliyat sonrası NOSE ve SNOT-22 skorları, ameliyat öncesi skorlara kıyasla, anlamlı düzeyde düşük idi (p
GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ
Authors: TANDIRCIOĞLU Ümit Ayşe , DOĞAN Özge , PELİT Pelin , CAGAN Murat , ÖZCAN Sanem , ÖZYÜNCÜ Özgür , YİĞİT Şule , ÇELİK Tolga
Published: April 2023

Amaç: Çin’in Wuhan kentinde ortaya çıkan COVID-19 pandemisi, dünyada 670 milyondan fazla insanı etkilemiştir. Her yaş grubunda görülen hastalığın mortalite ve morbiditesi özellikle yaşlı nüfus, kronik hastalığı olanlar ve gebelerde daha fazla gözlemlenmiştir. Bu çalışmanın amacı, pandemi sürecinde hastanemizde takip edilen ve doğum yapan, gebeliğinde COVID-19 enfeksiyonu geçirmiş gebelerin maternal ve neonatal sonuçlarını-morbiditelerini incelemek ve COVID-19 geçirmemiş gebelerin sonuçları ile karşılaştırmaktır. Gereç ve Yöntemler: Hastanemizde Nisan 2020-Haziran 2021 tarihleri arasında izlenen ve çalışma şartlarını sağlayan gebelerin ve bebeklerin maternal-neonatal verileri dosya kayıtlarından alınarak, gebelikte COVID-19 enfeksiyonu geçiren ve geçirmeyen gebeler ve bebeklerinden oluşan ikili gruplar karşılaştırıldı. Bulgular: Çalışmaya 2164 anne ve bebek çifti dahil edildi. Gebeliğinde COVID-19 geçirmiş (n=66) ve geçirmemiş olan anneler (n=2098) ve bebekleri arasında anne yaşı, doğum şekli, doğum ağırlığı, doğum haftası, cinsiyet, APGAR skorları, yenidoğan yoğun bakım ünitesinde yatma süreleri bakımından anlamlı fark saptanmadı. Sonuç: Çalışma sonuçlarımız henüz etiyopatogenezi yeterince aydınlatılamamış olan COVID-19 enfeksiyonunun, maternal-neonatal risk ve hastalıkların üzerine etkisinin halen tam olarak bilinmediği görüşünü desteklemektedir.
Mistuning Identification of Blisks Using Mass Detuning and Influence Coefficients
Authors: Cimpuieru Mihai , Kelly Sean T. , Lupini Andrea , Keener Christopher , D’Souza Kiran , Epureanu Bogdan I.
Published: May 2023

Integrally bladed disks, also known as blisks, are important components in the operation of gas turbines. To study the dynamics of these structures, several computational techniques approximate blisks as tuned systems, where all blades have the same characteristics. In reality, manufactured blades have small variations from their intended design, thus creating so-called mistuned systems. Previous work has shown that such small variations can cause high response amplifications that can result in blisk structural failure. Therefore, it is essential to identify mistuning to ensure the safe operation of these systems. Several methods utilize cantilever blade frequencies in their procedure to model mistuning and calculate blisk vibration response. A previously developed mistuning identification method uses mass detuning to isolate the cantilever blade frequencies and a set of influence coefficients to quantify the blade-to-blade couplings. However, the mistuning is calculated with respect to an arbitrary mistuning value that later needs to be identified through a trial-and-error procedure that can affect the accuracy of the final mistuning values. This paper focuses on updating the method to eliminate this additive error that cannot precisely be determined. Furthermore, the updated procedure is applied to an as-manufactured blisk using experimental ping test results. An additional analysis is performed on the effect of adding multiple sets of influence coefficients to capture the blade-to-blade couplings more accurately.
Música, cultura e arte: percepção dos usuários de um Centro de Atenção Psicossocial (CAPS) sobre uma oficina terapêutica
Authors: Magalhães João Lucas Barbosa , Braga Filipe Willadino
Published: April 2023

Objetivo: Identificar se para os usuários de um Centro de Atenção Psicossocial (CAPS) a oficina de música é considerada como dispositivo de cuidado à saúde mental. Métodos: Trata-se de uma pesquisa exploratória de campo de cunho qualitativo, que se desenvolveu obedecendo às seguintes etapas: coleta de dados através da aplicação de entrevistas narrativas com usuários de um CAPS e análise dos dados coletados com base na hermenêutica da profundidade. Resultados: Foi possível observar a importância de uma terapêutica que trabalha a arte, cultura e música na qual os usuários são os protagonistas, destacando a criação de vínculos por meio da convivência e reabilitação social, que podem ser observados na maneira em que a experiência do grupo reverbera no cotidiano das relações pessoais dos participantes. Conclusão: A pesquisa contribui para a melhora do entendimento acerca do papel de uma oficina de música como instrumento terapêutico nos serviços substitutivos de saúde mental. O estudo possui limitações com relação a amostra ter sido pequena e analisada em um contexto regional.
Curvature change of moving bodies and its application for development of protective elements for protective clothing
Authors: Muenks Dominik , Kyosev Yordan , Shuang Xia
Published: April 2023

When the human body moves, the body curvatures always change on the corresponding parts of the body. For ideal protective clothing, body curvatures during different movements have to be taken into account, as they influence the protection and the wearing comfort. For this reason, this study will focus on demonstrating methods to visually display such curvature changes. The changes are visually shown in different poses. The aim is to use this method to optimize protective elements on body parts with increased curvature changes. This would make protective clothing safer and more comfortable to wear.
Quality of Life in Bipolar Disorder: Portuguese validation of the Brief QoL.BD questionnaire
Authors:   Univ Coimbra, Centre for Research in Neuropsychology and Cognitive Behavioural Intervention (CINEICC), Azevedo Julieta , Roque Maria ,   Univ Coimbra, Centre for Research in Neuropsychology and Cognitive Behavioural Intervention (CINEICC), Carreiras Diogo ,   Univ Coimbra, Centre for Research in Neuropsychology and Cognitive Behavioural Intervention (CINEICC), Castilho Paula ,   Univ Coimbra, Centre for Research in Neuropsychology and Cognitive Behavioural Intervention (CINEICC), Macedo António ,   Coimbra Institute for Biomedical Imaging andTranslational Research (CIBIT), Portugal
Published: May 2023

The Brief Quality of Life in Bipolar Disorder (Brief QoL.BD) questionnaire is a short version of the first disorder-specific scale developed for Bipolar Disorder (BD), the QoL.BD, designed for use in research settings. This questionnaire has been considered a useful measure to assess psychological interventions’ improvements. This study aimed to validate and assess the psychometric properties of the Brief QoL.BD. Method: The Brief QoL.BD questionnaire was translated to Portuguese according to international guidelines, and participants with BD, psychiatrists and psychologists were consulted regarding its intelligibility. It was then administered to 110 people with BD (M = 43.81 ± 11.72, 66.4% ♀; 33.6% ♂), in addition to other self-report questionnaires, to assess satisfaction with life, anxiety, depression, external shame and positive and negative affect. Results: The Brief QoL.BD revealed good internal consistency (a = .84). Positive correlations with satisfaction with life and positive affect supported the scale’s convergent validity. Significant negative correlations supported the divergent validity with negative affect, depression, anxiety and external shame. Confirmatory factor analysis validated the original one-factor structure showing a good fit. Conclusion: The Portuguese translation of Brief QoL.BD questionnaire (European) proved to be a valid, and reliable quality of life measure to be used with people with bipolar disorder. BD type II displayed significantly lower levels of QoL than type I. Brief QoL.BD is short and easy to apply, being recommended for research purposes, specifically tracking psychological intervention’s impact.
Generative adversarial networks and diffusion models in material discovery
Authors: Alverson Michael , Baird Sterling , Murdock Ryan , Ho (Enoch) Sin-Hang , Johnson Jeremy , Sparks Taylor
Published: May 2023

The idea of materials discovery has excited and perplexed research scientists for centuries. Several different methods have been employed to find new types of materials, ranging from the arbitrary replacement of atoms in a crystal structure to advanced machine learning methods for predicting entirely new crystal structures. In this work, we pursue three primary objectives. I) Introduce CrysTens, a crystal encoding that can be used in a wide variety of deep-learning generative models. II) Investigate and analyze the performance of Generative Adversarial Networks (GANs) and Diffusion Models to find an innovative and effective way of generating theoretical crystal structures that are synthesizable and stable. III) Show that the models that have a better “understanding” of the structure of CrysTens produce more symmetrical and realistic crystals and exhibit a better apprehension of the dataset as a whole. We accomplish these objectives using over fifty thousand Crystallographic Information Files (CIFs) from Pearson’s Crystal Database.
Exploring different carbon allotrope thermoplastic composites for electrochemical sensing
Authors: Hussain Khalil , Shergill Ricoveer , Hamzah Hisham , Yeoman Mark , Patel Bhavik
Published: May 2023

Composite electrodes are an effective and cheap way to utilise a wide range of carbon materials to make electrodes. More recently thermoplastics have been widely used as the binder to make carbon composite electrodes, as varying fabrication approaches, such as 3D printing, can make highly reproducible electrodes. However, there is a clear need to understand how the electrochemical performance of different carbon allotrope materials varies when made into sensors. We accessed polylactic acid (PLA) thermoplastic filaments containing carbon black, graphite, graphene, multiwall carbon nanotube (MWCNT) and carbon fiber using various electrochemical techniques. Graphite/PLA and graphene/PLA electrodes showed the best electron transfer kinetics. Graphene/PLA electrodes had the greatest sensitivity and lowest limit of detection for the measurement of serotonin. CB/PLA was least prone to electrode fouling from oxidative by-product generated from the oxidation of serotonin. 3D printing was used to make various carbon allotrope materials into complex shapes to evaluate the batch uniformity of the printed parts. Of all the materials explored, CB/PLA had the best resolution and batch uniformity when compared to PLA. Overall, our study highlights that the type of the carbon allotrope plays as much influence as amount of carbon on the electrochemical performance of carbon thermoplastic electrodes. These findings will provide significant guidance on the appropriate choice of carbon thermoplastic composite materials when designing electrodes for a wide range of applications.
Active, selective, and stable single-component precatalysts for asymmetric allylic alkylation
Authors: Huang Jingjun , Keenan Thomas , Richard Francois , Lu Jingru , Jenny Sarah , Jean Alexandre , Arseniyadis Stellios , Leitch David
Published: May 2023

The stereoselective construction of new carbon-element bonds is a crucial aspect of organic synthesis. Among the many strategies developed to date, palladium-catalysed asymmetric allylic alkylation is commonly used to access chiral molecules in natural product and active pharmaceutical ingredient synthesis. The use of modular Trost-type ligands and phosphinooxazoline (PHOX) ligands results in generally high stereoselectivity for a wide range of transformations. However, these reactions nearly always require relatively high catalyst loadings (5-10 mol%), reaction-specific catalyst preactivation protocols, and excess chiral ligand to ensure high yield and selectivity. Here we report the isolation and catalytic evaluation of a series of chiral palladium(0) single-component precatalysts that are active for a variety of asymmetric allylic alkylation reactions. The four Trost-type precatalysts in this work are the first characterized examples of stable, isolable Pd complexes with the diphosphines coordinated in the desired κ2-P,P fashion. All of the palladium(0) complexes are stable for >12 months when stored under nitrogen, and can be handled as solids and even in solution under air for hours without decomposition. A catalytic evaluation of these single-component precatalysts across 9 distinct asymmetric allylic alkylation reactions reveals excellent performance in terms of reactivity, selectivity, practicality, and minimizing palladium and chiral ligand loading. This enables both small-scale multivariate screening studies and preparative scale synthesis of key chiral building blocks, exemplified with the unprecedented enantioselective allylation of hydantoins. The optimized reaction achieves high yield and enantioselectivity with only 0.2 mol% of catalyst (turnover number of 465). These precatalysts will enable development of more efficient and robust asymmetric allylic alkylation reactions toward complex target molecules.
Determining the Complete Stability of Calcite Kink Sites: Real vs Ideal
Authors: Armstrong Blake , Silvestri Alessandro , De La Pierre Marco , Raiteri Paolo , Gale Julian
Published: May 2023

Kink sites play a pivotal role in the growth and dissolution of materials at the solid-liquid interface. Despite this, little is known about the thermodynamic stability of such sites. Calcium carbonate, in the form of calcite, is one of the most abundant biominerals and a natural means of carbon sequestration in the environment. Here we present a complete determination of the standard free energies for all 16 individual kink sites for the significant case of the calcite (10-14)--water interface using both alchemical and pathway-based simulation techniques. The results reveal the importance of distinguishing between real and ideal ion-binding free energies at surfaces, especially for calcite-water where the interfacial potential can alter values by more than 100 kJ/mol per site. Individual kink site stabilities are found to show variations in excess of 60 kJ/mol, which can help explain observed differences in growth rates between the two distinct steps of calcite.
Prolonged Circulation and Enhanced Tumor Uptake of PEGylated Nanoparticles by Manipulation of Nanoscale Surface Topography
Authors: Grundler Julian , Shin Kwangsoo , Suh Hee-Won , Whang Chang-Hee , Saltzman W. Mark
Published: May 2023

Improving the performance of nanocarriers remains a major challenge in the clinical translation of nanomedicine. Efforts to optimize nanoparticle formulations typically rely on tuning the surface density and thickness of stealthy polymer coatings such as poly(ethylene glycol) (PEG). Here, we show that modulating the surface topography of PEGylated nanoparticles using bottlebrush block copolymer (BBCP) significantly enhances circulation and tumor accumulation providing an alternative strategy to improve nanoparticle coatings. Specifically, nanoparticles with rough surface topography achieve high tumor cell uptake in vivo due to superior tumor extravasation and distribution compared to conventional smooth-surfaced nanoparticles. Furthermore, surface topography profoundly impacts the interaction with serum proteins resulting in the adsorption of fundamentally different proteins onto the surface of rough-surfaced nanoparticles formed from BBCPs. We envision that controlling the nanoparticle surface topography of PEGylated nanoparticles will enable the design of improved nanocarriers in various biomedical applications.
ANALISIS IMPOR DAGING SAPI DI INDONESIA
Authors: Laela Nur , Natsir Mohammad , - Rahmawati
Published: April 2023

Penelitian ini bertujuan untuk menganalisis perkembangan produksi daging sapi di Indonesia, siklus perkembangan produksi daging sapi di Indonesia tahun, dan elastisitas impor daging sapi pada faktor harga impor daging sapi, kecukupan, dan pendapatan perkapita di indonesia.Sumber data yang digunakan dalam penelitian merupakan data yang diperoleh dari lembaga FAO STAT (Food and Agriculture Organization), Badan Pusat Statistik, dan Uncomtrade. Data dalam penelitian ini adalah data sekunder dalam bentuk time series selama 20 tahun, yaitu tahun 2000-2019. Analisis data yang digunakan, yaitu analisis trend linier, analisis trend non linier, dan analisis regresi ganda model Cobb douglas. Hasil analisis trend linier produksi daging sapi di Indonesia selama 20 tahun dari tahun 2000-2019 menunjukkan trend negatif. Hasil analisis trend non linier polinemial of orde-4 menunjukkan keadaan siklus naik dan turun selama dua kali. Siklus naik menunjukkan produksi daging sapi meningkat dan siklus turun menunjukkan produksi daging sapi menurun. Sedangkan pada tingkat elastisitas, harga impor daging sapi bersifat elastis terhadap impor daging sapi sebesar -1,2147, elastisitas rasio kecukupan bersifat hampir elastis sebesar -0,9470, dan pendapatan perkapita terhadap impor daging sapi bersifat tidak elastis (inelastis) dengan nilai koefisien sebesar 0,6045.
ANALISIS RESIKO USAHA AYAM POTONG MANDIRI DAN ALTERNATIF PENANGGULANGANNYA
Authors: Mappa Nurdin , Rahmawati Rahmawati , Nurfadillah Nurfadillah
Published: April 2023

Dunia agribisnis dipenuhi dengan berbagai jenis resiko, terutama pada subsistim budidaya oleh karena berkaitan dengan makhluk hidup, termasuk dalam usaha ayam broiler, yang memerlukan penanggulangan untuk meminalisir kerugian yang diakibatkan oleh resiko, yang kemungkinan akan terjadi.  Penelitian ini bertujuan untuk menganalisis resiko pada usaha ternak ayam broiler mandiri  dari segi   produksi,  pemasaran dan alternatif penanggulangan risiko pada usaha ternak ayam Broiler mandiri di Desa Cenrana Kecamatan Kahu Kabupaten Bone. Pengambilan informan dalam penelitian ini dilakukan dengan cara sengaja atau purposive sampling Sebanyak 4 orang peternak ayam broiler mandiri. Pengumpulan data dilakukan melalui wawancara dan   analisis data deskriptif kualitatif. Hasil penelitian menunjukkan bahwa risiko yang dihadapi dalam usaha ternak ayam broiler di Desa Cenrana Kecamatan Kahu Kabupaten Bone ada dua yaitu resiko dalam produksi yaitu morthalitas yang disebabkan oleh penyakit dan cuaca  sedangkan  resiko dalam pemasaran yaitu ayam tidak laku terjual dan harga ayam turun. Adapun  Alternatif yang dilakukan untuk menaggulangi risiko kematian adalah tetap menjaga kebersihan dan kestrerilan perlatan serta melindungi ayam dari cuaca sedangkan penanggangulangan resiko pemasaran adalah  membawa langsung ayam ke pasar secukupnya  dan mencari pelanggan tetap, serta berusaha menjual langsung ke konsumen.
KETAHANAN PANGAN DAN PENINGKATAN PENDAPATAN PETANI MELALUI TUMPANG SARI KANGKUNG DAN KELOR DI KELURAHAN BONTORAMBA KECAMATAN SOMBAOPU KABUPATEN GOWA
Authors: Ardiansyah Muh. , Halil Abdul , Syarif Asriyanti , Anwar Andi Rahayu
Published: April 2023

AbstractThe water Spinach and morinaga intercropping system is an agricultural  product in the context of increasing farmer income and efforts to fulfill family food. The research was conducted in the Bontoramba sub-district, Sombaopu District, Gowa Regency by sampling in a saturated sample with a total of 36 farmers doing intercropping farming of moringa and kale. The sampled farmers were given questions using a questionnaire guide and conducted group discussion forums (FGD). Data were analyzed using income analysis, and farmers' perceptions of food security (income, available food sources, as well as the level of farmers' knowledge were analyzed in percentage form and strengthened by presentation in verbal form. Income from water spinach farming was Rp.1,896. 178.22/Ha in one growing season, while Moringa farming provides an income of IDR 669,954.91/Ha. Kale farming income is greater than Moringa because the amount of production is greater than Moringa.Meanwhile, farmers' perceptions of food security in terms of income with the system intercropping, they agree by 83.33% that income provides an alternative for farmers to fulfill food in order to support food security Farmers' perceptions of food security in terms of fulfilling food needs, they agree by 100% that intercropping can meet food needs (vegetables) for farmers and lutes price, and nutritional needs are met. Farmers' perceptions of food security in terms of knowledge agree by 77.78% that there are benefits from these two plants being intercropped as vegetables, although there is still a lack of knowledge about the other benefits of kale and moringa plants, as well as more detailed knowledge of the reasons for these two plants being intercroppedKeywords: food security, income, intercropping, kale, moringa
PENGARUH HARGA INPUT PRODUKSI TERHADAP PENDAPATAN USAHATANI PADI SAWAH IRIGASI DI KECAMATAN BONE-BONE KABUPATEN LUWU UTARA PROVINSI SULAWESI SELATAN
Authors: Rusman Muh Al Aswar
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pendapatan usahatani dan mengetahui pengaruh harga faktor-faktor produksi terhadap pendapatan usahatani sawah irigasi. Berlokasi di Kelurahan Bone-Bone, Kecamatan Bone-Bone, Kabupaten Luwu Utara, Sulawesi Selatan. Data yang digunakan merupakan data primer, berupa data kuantitatif. Teknik pengumpulan data yakni menggunakan kuesioner yang sampelnya ditentukan dengan teknik acak sederhana (Simple Random Sampling). Analisis data yang digunakan yakni analisis regresi berganda yang bertujuan mengetahui pengaruh faktor-faktor produksi terhadap pendapatan dan untuk mengetahui hubungan antar variabel dependent dan independent maka dilakukan Uji-F dan Uji-T. Hasil penelitian menunjukkan bahwa nilai koefisien determinasi (R2) sebesar 0,9083 hal ini berarti bahwa sebesar 91% variabel X yang dianalisis mampu menjelaskan variasi variabel Y sedangkan 9% dijelaskan oleh variabel lainnya yang tidak dimasukkan dalam analisis. Kemudian dalam uji F ditemukan bahwa seluruh variabel dependen (X1,X2,X3,X4,X5) secara simultan memiliki pengaruh terhadap variabel independen yaitu pendapatan (Y) dengan nilai signifikansi sebesar 0.000 yang jauh dari taraf yang digunakan dalam penelitian yakni 0,05. Sedangkan hasil uji T ditemukan secara parsial maka hasil menunjukkan hasil yang bervariasi dimana variabel luas berpengaruh dan variabel upah tenaga kerja berpengaruh signifikan terhadap pendapatan usahatani padi sawah irigasi di Kelurahan Bone-Bone, Kecamatan Bone-Bone, Kabupaten Luu Utara.
Preface
Authors: Smith ATH
Published: April 2023

This article serves as a preface to this special issue of the Victoria University of Wellington Law Review celebrating its 60th anniversary. The author, then the Dean of the Faculty of Law, provides a brief overview of the Law Review's history as well as its current state.
Tribute to Rt Hon Sir Ivor Richardson, PCNZM
Authors: McGrath John
Published: April 2023

The following is a tribute to the late Sir Ivor Richardson. It was delivered by Justice John McGrath at a memorial service held at Old St Paul's in Wellington on 29 January 2015.
Colour and the City
Authors:   , Frame Anna
Published: April 2023

The city is rarely considered as a creative field, like painting and sculpture are. Each building is placed into its cadastral site, one metre from the boundary, and extruded to it’s maximum height according to council regulations. Often the designs entail extensive glazing, and grey tones. Sometimes, colour is used to accent form - but it is often seen as an afterthought to the formal qualities of our urban environments.

The research explores how we might utilise the physiological qualities of colour through form, in relation to the city. Instead of simply using colour as mere decoration, how can it contribute to the fabric of the city?

In this thesis I explore how colour operates on the city through my own creative practice. I use painting as a method to explore relationships of colour. The complexities and contradictions between the boundary of art and architecture are navigated through the realm of colour.

This design-led research is realised through the primary design being a mixed-use urban scheme in Newtown, Wellington. The scheme explores issues of urban circulation and density, with the primary design outcome consisting of an elevated pathway, a laneway, a cafe, a community gallery, green space and medium density housing.

This thesis proposes that the physiological qualities of colour can alter our perceptions of architectural form. By designing through colour, we can contribute to the future character of our city, and the composition of the urban fabric.
MODELOS MACHINE LEARNING EN GEOMECÁNICA MINERA PARA EL CONTROL EFICAZ DE PERFORACIÓN
Authors: Poma Cruz Hitler Juan
Published: May 2023

El estudio se ha realizado en la Unidad Minera San Rafael, distrito Antauta, provincia Melgar, donde se identificó el problema para el modelo adecuado de machine learning en geomecánica minera para el control eficaz de perforación y voladura en labores de avance, siendo el objetivo principal evaluar los modelos machine learning en geomecánica minera para el control eficaz de perforación y voladura en labores de avance. Los datos de operación referidos a malla y longitud de perforación, tipo de agentes de voladura, tipo y sección de la labor, tipo de roca, mineral y desmonte, número de taladros, avance esperado, avance logrado, estructura, tipo de perforación, equipo y operador, todos estos datos se registraron en formato de reporte, consolidados ellas en una hoja de cálculo y exportados a programación lineal R, las muestras sirvieron para elaborar diferentes modelos, para ser analizados, evaluados y determinados los factores más importantes en el control de avance lineal de las labores de exploración, desarrollo y preparación, el estudio es de tipo descriptivo correlacional y diseño no experimental longitudinal, con los cuales se ha obtenido como resultado que nos permite identificar el objetivo que es el modelo de aprendizaje supervisado que es aplicable y aceptable, cuya conclusión es el uso de modelos de machine learning en el contexto es factible desde un punto de vista computacional, sin embargo, se requiere un fuerte trabajo adicional en la curatoría de datos.
El uso de insulina en pacientes con diabetes tipo II
Authors: Sandoval Benalcázar Diana Carolina , Socasi Dioses Edwin Geovanny , Vera Navarrete Edison Manuel , Poaquiza Pacheco Daniel José
Published: May 2023

Muchos pacientes con diabetes tipo 2 requieren y se benefician de la insulinoterapia, la cual sigue siendo un tratamiento eficaz en el control de la diabetes. Sin embargo, la motivación y el inicio del tratamiento siguen siendo una dificultad frecuente. Entre los problemas descritos, referidos como barreras, se encuentra la actitud negativa del paciente y la percepción de incapacidad al uso del medicamento. La metodología utilizada para el presente trabajo de investigación, se enmarca dentro de una revisión bibliográfica de tipo documental. La técnica para la recolección de datos está constituida por materiales electrónicos, estos últimos como Google Académico, PubMed, Science direct, entre otros, apoyándose para ello en el uso de descriptores en ciencias de la salud o terminología MESH. La información aquí obtenida será revisada para su posterior análisis. La diabetes tipo II es una enfermedad crónica frecuente, su descontrol o inadecuado control puede llegar a representar complicaciones variadas para las personas que la padecen. La función pancreática disminuye con el tiempo, este hecho hace que los pacientes necesiten insulina para compensar tal disfunción, hay diferentes tipos de esquemas de insulinización y de insulinas, su uso va a depender del grado de avance y comorbilidades que presente el paciente con diabetes tipo II. Los pacientes que utilizan por primera vez insulina basal, seguido de insulina prandial en comidas grandes y en las comidas que lo requiera tiene ventajas, ya que hay mayor reducción de los niveles glicémicos y menor riesgo de hipoglicemia. Se ha demostrado que la utilización de insulinas recombinantes representa una opción efectiva, segura y más accesible que los análogos de insulina. No solo deben establecerse el uso de la insulina, sino seguir patrones estrictos en cuanto a cambios en el estilo de vida como nutrición, patrones de alimentación, actividad física, optimización del control metabólico y prevención de complicaciones.
Yüzen Evlerde Sürdürülebilirlik Kavramı
Authors: TAVŞAN Filiz , PERVANOĞLU Sümeyye , TAVŞAN Cengiz
Published: April 2023

Yoğunlaşan nüfustan doğan konut ihtiyacı ve alan yetersizliğinden dolayı mikro konutlara ihtiyaç talebi artmaktadır. Küresel ısınmanın etkisi su seviyesinin artmasıyla taşkınların sık olduğu nehir ve göl yataklarının bulunduğu ülkelerde yüzen evler çoğalmaktadır. Yüzen evler palafitler, amfibikler ve bot evler olmak üzere, karayla olan temasına göre üç gruba ayrılmaktadır. Sürdürülebilirlik açısından önemli olan bu konut tipi çevre dostu ve genellikle enerji tasarruflu sistemlerden, teknelerden dönüştürülerek inşa edilmektedir. Geri dönüştürülebilir, su ve enerji korunumu yüksek olan bu evler alan ve sürdürülebilirlik için oldukça elverişli olan konut sistemlerinden biri haline gelmiştir.

Makalede yüzen evler ele alınmış ve sürdürülebilirlik olgusu incelenmiştir. Çalışmada, literatür tarama yöntemi ile 2000-2020 yılları arasında toplam 93 adet yüzen ev tespit edilmiştir. Bu örneklerden sürdürülebilir kriterleri sahip olanlar seçilerek 10 örnek çalışmaya dahil edilmiştir. Sürdürülebilirlik kriterler (malzeme, su, çevre ve enerji korunumu, iç ortam kalitesi, yeşil çatı ve esnek mobilya) başlıkları kapsamında konu açıklanmış ve örnekler bu kriterlere göre analiz edilmiştir.

Mikro konut olarak adlandırabileceğimiz yüzen evlerin genellikle sürdürülebilir kriterler çerçevesinde inşa edildiği, yenilenebilir enerjiden, geri dönüştürülebilir malzemelerden faydalanıldığı görülmektedir. Mekanın yerleşimi ve kurgusu iyi analiz edilerek ısıl korunum ve mobilya seçimleri verimli bir şekilde yapılmaktadır. Yüzen evlerin artması doğaya dönüşün ve su korunumunun artmakta olduğu, çevrenin mümkün olduğunca korunmaya çalışmasında önemli birer yapı oldukları görülmüştür.
Dolgu Duvarlı Çerçevelerde Sıvanın Deprem Davranışına Katkısı
Authors: COZA Halit
Published: April 2023

Depreme dayanıklı yapı yönetmeliklerince sağlanması istenen koşulların amacı yapılarda olması istenen en düşük düzeyde güvenlik sağlanmasıdır. Daha iyi deprem davranışı ve daha yüksek güvenlik için yönetmelik koşullarının daha üstünde koşulların gerçekleştirilmesi gerekmektedir. Son yıllarda, özellikle ülkemizde üretilen betonarme yapıların, projelendirilmesi, uygulanması ve kullanılması esnasında yapılan birtakım hatalar veya verilen yanlış kararlar, yapıya taşıyıcı eleman ve malzeme açısından yapılması gereken bir takım müdahale ve değişiklikleri gerektirmektedir. Bu çalışmada, uygulamada çok karşılaşılan betonarme yapıların özelliklerini yansıtan 3 adet, 1/3 ölçekli, tek açıklıklı, tek katlı numuneler üzerinde, bu tür sistemlerin yatay yük taşıma kapasiteleri ve diğer davranış özelliklerini karşılaştırmak amacıyla deneysel bir dizi çalışmalar tasarlanmıştır. Deneylerin sonuçlarına göre belirli bir çevrim ve yatay yerdeğiştirmeden sonra dolgu duvar ile çerçeveler birbirinden ayrılmaya başlamışlardır. Dolgu duvarlı tek yüzü sıvalı ve çift yüzü sıvalı deney numunelerin yatay yük taşıma kapasiteleri, boş çerçeveye göre artmıştır. Çift yüz sıva uygulaması, tek yüzü sıva uygulaması ile karşılaştırıldığında, çerçevenin yatay yük taşıma kapasitesi, enerji sönümleme kapasitesi ve rijitlik değerleri artarak, çerçeveye, çok fazla olmamakla birlikte, olumlu katkı sağlamıştır.
Sekanslar Yoluyla Mekânsal Bütünlük: Mimari Tasarım İçin Çağdaş Senaryo Planlama Teknikleri
Authors: CUBUK Gencay
Published: April 2023

Araştırma temel bir soru etrafında şekillenir: Çağdaş senaryo tekniklerini oluşturan örtük yapılar, mimari tasarım sürecine nasıl uyarlanabilir? Bu bağlamda araştırmanın amacı, çağdaş senaryo tekniklerinin geliştirilmesinde rol oynayan soru setlerinin mimari tasarım sürecine uyarlanması ve sonuçların teorik açıdan tartışılarak mimariye uygunluğunun değerlendirilmesidir. Bu nedenle, ardışık sekansların incelenmesi ve senaryo tekniklerine odaklanan figürlerin açıklamaları literatür taraması yoluyla tartışılmaktadır. Rabiger, Truby, McKay, Snyder ve Kirsch gibi figürlerin eserlerinde kurgu tekniklerinin mekânsal bağlamına dair özler bulunması bu doğrultuda ele alınmıştır. Anlatı alanı ile mimari alan arasında sekans tabanlı bir kesişme alanı tanımlanarak araştırmanın özgünlüğü sağlanmıştır. Araştırmanın bulguları olarak, çağdaş senaryo tekniklerinin gelişimine aracılık eden soru setlerinin, özne ve hedef nesne değiştirilerek mimari tasarım süreçlerine uyarlanmasıyla elde edilen kavram havuzlarının, senaryo süreçlerindeki soru dizilerinin gelişimini dikkate alarak mimari tasarım süreçlerinin ilerletilebileceğini savunan figürlerin yaklaşımlarıyla örtüştüğü görülmüştür. Mimari tasarım sürecinin parçalara ayrılması yoluyla görünür kılınan özneler, nesneler ve eylemlerin, senaryo tabanlı stratejiler yoluyla yeniden yorumlanması, kullanıcı deneyimi odaklı temaların mimari tasarım adımlarına entegre edilebilmesi açısından önemlidir. Sonuç olarak, çağdaş senaryo tekniklerinin örtük iskeletinin mimari tasarım süreçlerine uyarlanabileceği ve bu sayede kullanıcı deneyiminin iyileştirilebileceği anlaşılmaktadır.
Analisis Strategi Pemasaran Dalam Meningkatan Daya Saing Bisnis Toko Filosofi Gift Di Kota Makassar
Authors: Bakhtiar Bakhtiar , Rizal S Muh. , Niswaty Risma , Rivai Andi Muhammad , Reskiyanti Ika
Published: May 2023

Penelitian ini bertujuan untuk..mengetahui bagaimana penerapan strategi pemasaran Toko Filosofi Gift dalam meningkatkan daya saing bisnis.Untuk mengetahui apa faktor determinan dalam penerapan strategi pemasaran Toko Filosofi Gift dalam  meningkatkan daya saing bisnis. Adapun jumlah informan dalam penelitian ini yaitu berjumlah 10 orang dengan representative dan memenuhi kriteria dalam penelitian ini. Teknik pengumpulan data dalam penelitian ini melalui metode observasi, wawancara, dan dokumentasi. Teknik analisis data dalam penelitian ini menggunakan  reduksi data, penyajian data, dan menarik kesimpulan/verifikasi. Hasil penelitian ini menunjukkan bahwa penerapan strategi pemasaran menggunakan tiga strategi yaitu segmentation marketing, targeting, positioning. Strategi pemasaran lainnya yang digunakan yaitu bauran pemasaran yang diantaranya product, price, place, and promotion. Adapun faktor determinan dalam penerapam strategi pemasaran yaitu faktor pendukung yag terdiri dari kualitas produk, sosial media, dan perizinan usaha. Adapun faktor penghambatnya terdiri dari biaya pemasaran, bahan baku, faktor harga, dan faktor persaingan