bluuebunny/crossref_metadata_2025 huggingface dataset:
SINGLE-LEG HOP PERFORMANCE IS A PREDICTOR FOR PATIENT-REPORTED OUTCOMES FOLLOWING A LOWER EXTREMITY INJURY
Authors: Simon Janet E. , Yom Jae , Grooms Dustin R.
Published: March 2019

Background:

The single-leg hop for distance (SLHOP) is a commonly used functional performance measure to determine return-to-play readiness. However, it is unknown if functional performance at return-to-play can predict future patient outcomes. Therefore, the purpose of this study was to determine if SLHOP performance and symmetry at return-to-play following a lower extremity injury would predict lower extremity patient-reported outcomes six months post-injury.

Methods:

Two-hundred thirty-six adolescent athletes (15.7±1.4 years, 171.1±7.6 cm, 70.3±15.3 kg) were recruited for this study. If an individual sustained a non-surgical lower extremity injury during their sports season and missed three days of sports participation they were eligible for follow-up functional and patient outcome assessment Thirty-two adolescent athletes were eligible and completed the follow-up testing (15.0±1.1 years, 166.5±4.9 cm, 67.3±10.4 kg; 14 American football, 8 volleyball, 4 girls’ basketball, 6 boys’ basketball athletes). The SLHOP was completed by affixing a tape measure to the ground and instructing the participant to hop on one leg as far as possible. Each participant performed three trials per leg at return-to-play (alternating legs). To be counted as a successful trial the participant maintained postural stability for 2 seconds after the landing and the contralateral leg was not allowed to touch the ground. The Pediatric Patient-Reported Outcomes Measurement Information System (PROMIS) Lower Extremity scale was completed six months after return-to-play as the patient-reported outcome measure. A stepwise multiple linear regression was conducted to predict PROMIS Lower Extremity scale score from SLHOP distance on the injured and uninjured leg (cm), and limb symmetry (%).

Results:

At step one of the analysis, injured limb SLHOP distance was entered into the regression equation and was significantly related to the PROMIS Lower Extremity scale F(1,31)=20.8, p<.001. The multiple correlation coefficient was 0.79, indicating approximately 62% of the variance of the PROMIS Lower Extremity scale scores could be accounted for by the injured limb SLHOP distance. Specifically, for every increase in one cm of SLHOP performance there would be an increase of 0.6 points on the PROMIS Lower Extremity scale. Uninjured limb SLHOP distance and limb symmetry did not enter into the equation at step two of the analysis (p>.05).

Conclusion:

The SLHOP conducted at time of return-to-play following a lower extremity injury can predict lower extremity patient-reported outcomes six months later. This indicates that clinicians may be able to use the SLHOP following an injury to not only determine return-to-play readiness but a successful long-term outcome.
How does empagliflozin improve arterial stiffness in patients with type 2 diabetes mellitus? Sub analysis of a clinical trial
Authors: Bosch Agnes , Ott Christian , Jung Susanne , Striepe Kristina , Karg Marina V. , Kannenkeril Dennis , Dienemann Thomas , Schmieder Roland E.
Published: March 2019

Background

Empagliflozin has been shown to reduce cardiovascular mortality, but the underlying pathogenetic mechanisms are poorly understood. It was previously demonstrated that empagliflozin improved arterial stiffness.

Methods

Our analysis comprising 58 patients with type 2 diabetes mellitus identifies factors triggering the improvement of arterial stiffness. All patients participated in an investigator-initiated, prospective, double-blind, randomized, placebo-controlled, interventional clinical trial (http://www.ClinicalTrials.gov: NCT02471963, registered 15th June 2015, retrospectively registered) and received either 6-weeks treatment with 25 mg empagliflozin orally once daily or placebo (crossover). Central systolic pressure and central pulse pressure were recorded by the SphygmoCor System (AtCor Medical). Now, we investigated the impact of parameters of glucose metabolism, volume status, sympathetic activation, lipids, uric acid, blood pressure and inflammation on vascular parameters of arterial stiffness using multivariate regression analysis.

Results

As previously reported, therapy with empagliflozin improved arterial stiffness as indicated by reduced central systolic blood pressure (113.6 ± 12.1 vs 118.6 ± 12.9 mmHg, p < 0.001), central pulse pressure (39.1 ± 10.2 vs 41.9 ± 10.7 mmHg, p = 0.027) forward (27.1 ± 5.69 vs 28.7 ± 6.23 mmHg, p = 0.031) as well as reflected wave amplitude (18.9 ± 5.98 vs 20.3 ± 5.97 mmHg, p = 0.045) compared to placebo. The multivariate regression analysis included age, sex and change between empagliflozin and placebo therapy of the following parameters: HbA1c, copeptin, hematocrit, heart rate, LDL-cholesterol, uric acid, systolic 24-h ambulatory blood pressure and high sensitive CRP (hsCRP). Besides the influence of age (beta = − 0.259, p = 0.054), sex (beta = 0.292, p = 0.040) and change in systolic 24-h ambulatory blood pressure (beta = 0.364, p = 0.019), the change of hsCRP (beta = 0.305, p = 0.033) emerged as a significant determinant of the empagliflozin induced reduction in arterial stiffness (placebo corrected). When replacing HbA1c with fasting plasma glucose in the multivariate regression analysis, a similar effect of the change in hsCRP (beta = 0.347, p = 0.017) on arterial stiffness parameters was found.

Conclusion

Besides age and sex, change in systolic 24-h ambulatory blood pressure and change in hsCRP were determinants of the empagliflozin induced improvement of vascular parameters of arterial stiffness, whereas parameters of change in glucose metabolism and volume status had no significant influence. Our analysis suggests that empagliflozin exerts, at least to some extent, its beneficial vascular effects via anti-inflammatory mechanisms.

Trial registrationhttp://www.ClinicalTrials.gov: NCT02471963, registered 15th June 2015, retrospectively registered
Community treatment orders: international perspective
Authors: Mikellides Georgios , Stefani Artemis , Tantele Marianna
Published: March 2019

The use of community treatment orders (CTOs) is available in more than 70 jurisdictions around the world. Although CTOs are used extensively, their effectiveness remains doubtful. We comment on the existing evidence and focus on components that influence the outcomes of CTOs internationally. It is essential to identify factors that affect the delivery of CTOs, and mixed methodologies may improve our understanding regarding their efficiency.
Distinguished Service Awards in Anesthesiology Specialty Societies: Analysis of Gender Differences
Authors: Ellinas Elizabeth H. , Rebello Elizabeth , Chandrabose Rekha K. , Shillcutt Sasha K. , Hernandez Mike , Silver Julie K.
Published: March 2019

The authors queried 9 anesthesiology societies to examine Distinguished Service Award recipients over time by gender. Of the 211 total Distinguished Service Awards given by all 9 societies, women received 25 (11.8%). Comparing pre-2008 data to the most recent decade, there was no statistical difference in the number of women Distinguished Service Award recipients with 8.9% and 17.1% women Distinguished Service Award recipients, respectively (P = .076). Societies varied greatly in their women awardees, from 40% to 0% in the last decade. Low levels of awardees stand in contrast to the increasing number of women in the academic pipeline. The authors recommend that societies collect gender membership data and study their award processes from nomination to selection.
Cardiopulmonary Profile of Individuals with Intellectual Disability
Authors: BOONMAN ANNE J. N. , SCHROEDER ELIZABETH C. , HOPMAN MARIA T. E. , FERNHALL BO , Hilgenkamp THESSA I. M.
Published: March 2019

Introduction

Individuals with intellectual disabilities (ID) are often sedentary and have low fitness levels. Current knowledge supports the existence of physiological barriers resulting in low fitness and exercise intolerance in individuals with Down syndrome, which might be applicable to other ID etiologies. If physiological barriers exist in ID, this would require adaptation of the physical activity guidelines.

Purpose

The aim of this study was to assess differences in cardiopulmonary profiles, including maximal oxygen uptake, during a cardiopulmonary exercise test in individuals with ID without Down syndrome and healthy controls.

Methods

Participants performed an incremental cardiopulmonary exercise test on a treadmill until exhaustion. Outcomes were peak heart rate (HRpeak), absolute peak oxygen uptake (V˙O2peak), relative V˙O2peak, peak minute ventilation, peak CO2 expenditure, oxygen uptake efficiency slope, V˙E/V˙CO2 slope, absolute O2 pulse, relative O2 pulse, difference from predicted HRpeak, HR reserve, RERpeak, ventilatory threshold (VT), and VT as a percentage of V˙O2peak. Differences between groups were analyzed with Student’s t-tests and multiple linear regression after adjusting for potential confounders (sex, age, body mass index, and activity level).

Results

Individuals with ID had worse outcomes on all of the cardiopulmonary outcomes, except for VT expressed as a percentage of V˙O2peak and V˙E/V˙CO2 slope (P < 0.05). Having ID was an independent predictor of reduced physiologic function during exercise (P < 0.05).

Conclusion

These results demonstrate that individuals with ID present exercise intolerance potentially related to lower HRpeak and impairments in ventilatory function, and these results also suggest the possibility of peripheral muscle hypoperfusion. Existing physical activity guidelines likely underestimate the actual intensity of activity performed by individuals with ID and need to be adapted.
Multiple myeloma of young adult presented with paraplegia, rare case report in Saudi Arabia
Authors: Barefah Ghaith , Almaghrabi Nizar Adnan , Elsini Rayan
Published: March 2019

Multiple myeloma is the second most common hematologic malignancy. It is characterized by the neoplastic proliferation of plasma cells in the bone marrow, leading to excessive production of monoclonal immunoglobulin. The mean age at diagnosis is 65 years. There are only a few cases of Multiple Myeloma arising in young population reported in the literature. We present a case of 33-years-old male presented with complete bilateral lower limbs paralysis and loss of sensation which were gradual in onset and accompanied by upper and lower back pain for 1 month. MRI of the whole spine show multiple infiltrative bone marrow high signal in T2 and STIR sequences involve C4 and the upper dorsal vertebral bodies and the spinous process of D4 with left para-spinal and large posterior epidural mass compress the spinal cord. CT guidance obtains three samples from the mass and placed in formalin in separate containers. Histopathology examination revealed neoplastic growth composed of Sheet of diffuse atypical plasma cells infiltrating fibro collagenous and adipose tissue. Although Multiple myeloma is a disease of elderly; it still could present in young age group. Histopathology examination is the gold standard for diagnosis.
Recent technical advances in proteomics
Authors: Yates, III John R.
Published: March 2019

Mass spectrometry is one of the key technologies of proteomics, and over the last decade important technical advances in mass spectrometry have driven an increased capability for proteomic discovery. In addition, new methods to capture important biological information have been developed to take advantage of improving proteomic tools.
Moisture-associated skin damage: use of a skin protectant containing manuka honey
Authors: Woodward Sue
Published: March 2019

The skin is the largest organ in the body, providing an effective barrier against excessive fluid loss and invasion from bacteria, but the barrier function of the skin can be lost when it is damaged by prolonged contact with moisture. Moisture-associated skin damage can be caused by prolonged exposure to perspiration, urine or faeces, wound exudate or stomal output. Prevention and treatment of moisture-associated skin damage involves application of skin protectants, but there is a wide range of these products available to nursing staff, and clinical decision making is hampered by a lack of robust comparative evidence. Medihoney® Barrier Cream may be used for a number of indications related to moisture-associated skin damage, including incontinence-associated dermatitis. The use of Medihoney Barrier Cream has been shown to lower pruritis complaints associated with intertrigo, and promotes patient comfort.
From staff nurse to nurse consultant Continuing professional development part 11: using reflection
Authors: Fowler John
Published: March 2019

John Fowler, Educational Consultant, explores CPD for clinically based nurses
Improving support systems to safeguard the mental health of NHS nurses
Authors: Glasper Alan
Published: March 2019

Emeritus Professor Alan Glasper, University of Southampton, discusses a new government pledge to implement recommendations from Health Education England to better meet the wellbeing needs of health professionals
Patient advocacy: a skill students can learn and practise before qualification
Authors: Bola-Arotiowa Olive
Published: March 2019

Olive Bola-Arotiowa, year 2 masters adult nursing student at University of Salford highlights the importance of advocacy as a nursing skill, as she reflects on how she was able to change the outcome for one patient
Properties and use of a honey dressing and gel in wound management
Authors: Henry Nader , Jeffery Steven , Radotra Ishan
Published: March 2019

Wound management is a major clinical challenge and puts a significant financial burden on the NHS. Because of the rise in long-term conditions including diabetes, obesity and an ageing population, practitioners regularly encounter a wide variety of wound types. In recent years, there has been a resurgence of interest in the use of medical-grade honey in the management of wounds. Honey is anti-inflammatory in action and has the capability to treat local infection, promote autolytic debridement, deodorise wounds and promote granulation tissue. Revamil is a recent addition to the range of honey dressings available and is intended to manage the majority of problems that may arise during wound care episodes. The attributes of Revamil will be illustrated through four case studies.
The Moderating Effect of Organizational Culture on the Relationship between Bullying and Machiavellianism
Authors: Savas Ahmet Cezmi
Published: March 2019

Workplace bullying is unwanted and unwarranted and has negative consequences for the victim, his colleagues and the whole organization. With the present study, we aim to clarify the interactive effects of workplace bullying from the victims’ perception and organizational culture on the teachers ‘Machiavellianism which is a personality syndrome aiming the realization of one’s own profits with every possible means. The sample consisted of 103 teachers working in different schools in Gaziantep, Turkey. Data was analyzed by the hierarchical multiple linear regression method at SPSS 22 and ModGraph-I was used at moderating tests. The results showed that being bullied was not a significant predictor of Machiavellianism. However, organizational culture significantly and positively predicted Machiavellianism, and the main effect of being bullied on Machiavellianism was qualified by the interaction: “higher Machiavellianism was associated with higher workplace bullying under conditions of higher organizational culture.” Organizational culture operated as an exacerbation under conditions of workplace bullying.
The Impact of Workplace Spirituality on Organizational Commitment at Schools: The Moderating Effect of Gender
Authors: Korkmaz Turgut , Menge Sahin
Published: March 2019

The purpose of this study is to investigate the impact of workplace spirituality on organizational commitment and the moderating role of gender. 112 teachers, working in Gaziantep, in the 2015-2016 academic year, were assessed using the workplace spirituality scale improved by Ashmos and Duchon and translated into Turkish by researchers and also the organizational commitment scale by Meyer and Allen, adapted to Turkish by Wasti. At the end of the research, it was found that there was a moderating role of gender in relation to workplace spirituality with organizational commitment. While the spirituality of the in workplace increases, organizational commitment increases, and male teachers’ organizational commitment was more than female teachers’
Unions of a clique and a co-clique as star complements for non-main graph eigenvalues
Authors: Stanic Zoran
Published: March 2019

Graphs consisting of a clique and a co-clique, both of arbitrary size, are considered in the role of star complements for an arbitrary non-main eigenvalue. Among other results, the sign of such a eigenvalue is discussed, the neigbourhoods of star set vertices are described, and the parameters of all strongly regular extensions are determined. It is also proved that, unless in a specified special case, if the size of a co-clique is fixed then there is a finite number of possibilities for our star complement and the corresponding non-main eigenvalue. Numerical data on these possibilities is presented.
Differential Microglial Morphological Response, TNFα, and Viral Load in Sedentary-like and Active Murine Models After Systemic Non-neurotropic Dengue Virus Infection
Authors: Gomes Giovanni Freitas , Peixoto Railana Deise da Fonseca , Maciel Brenda Gonçalves , Santos Kedma Farias dos , Bayma Lohrane Rosa , Feitoza Neto Pedro Alves , Fernandes Taiany Nogueira , de Abreu Cintya Castro , Casseb Samir Mansour Moraes , de Lima Camila Mendes , de Oliveira Marcus Augusto , Diniz Daniel Guerreiro , Vasconcelos Pedro Fernando da Costa , Sosthenes Marcia Consentino Kronka , Diniz Cristovam Wanderley Picanço
Published: March 2019

Peripheral inflammatory stimuli increase proinflammatory cytokines in the bloodstream and central nervous system and activate microglial cells. Here we tested the hypothesis that contrasting environments mimicking sedentary and active lives would be associated with differential microglial morphological responses, inflammatory cytokines concentration, and virus load in the peripheral blood. For this, mice were maintained either in standard (standard environment) or enriched cages (enriched environment) and then subjected to a single (DENV1) serotype infection. Blood samples from infected animals showed higher viral loads and higher tumor necrosis factor-α (TNFα) mRNA concentrations than control subjects. Using an unbiased stereological sampling approach, we selected 544 microglia from lateral septum for microscopic 3D reconstruction. Morphological complexity contributed most to cluster formation. Infected groups exhibited significant increase in the microglia morphological complexity and number, despite the absence of dengue virus antigens in the brain. Two microglial phenotypes (type I with lower and type II with higher morphological complexity) were found in both infected and control groups. However, microglia from infected mice maintained in enriched environment showed only one morphological phenotype. Two-way ANOVA revealed that environmental changes and infection influenced type-I and II microglial morphologies and number. Environmental enrichment and infection interactions may contribute to microglial morphological change to a point that type-I and II morphological phenotypes could no longer be distinguished in infected mice from enriched environment. Significant linear correlation was found between morphological complexity and TNFα peripheral blood. Our findings demonstrated that sedentary-like and active murine models exhibited differential microglial responses and peripheral inflammation to systemic non-neurotropic infections with DENV1 virus.
Educação e cidadania pela floresta autóctone
Authors: Alho José Manuel
Published: March 2019

A componente florestal na educação tem de ser tratada de forma integrada no domínio mais holístico do ambiente e da sustentabilidade. A educação apresenta-se como um instrumento fundamental para uma estratégia de sucesso tal como o ordenamento, o planeamento e os recursos financeiros disponibilizados, pois é a responsável pelos cidadãos que estamos a preparar para o futuro. No contexto atual do nosso País, após as tragédias vividas no ano passado, mas também em 2003 e 2005, a importância da educação enquanto processo continuado, ao invés da simples e pontual sensibilização, é vital para a prevenção de novas tragédias no futuro. São bem evidentes as mudanças de política que têm vindo a ser produzidas nos últimos tempos e que olham para a floresta e para o território numa alteração de paradigma a diversos níveis satisfatório, mas a educação tem de ser envolvida como pilar. Só através duma ligação profunda da floresta e dos ecossistemas na dinâmica da educação é que conseguimos garantir que estamos a apostar nessa mudança de paradigma para o futuro de modo estrutural em cada cidadão e por consequência nas nossas comunidades!
Grandes incêndios florestais de 17 de junho de 2017 em Portugal e exemplos da determinação das respetivas causas
Authors: Mira Messias , Lourenço Luciano
Published: March 2019

Portugal apresenta condições muito favoráveis à ocorrência de incêndios florestais, a maioria dos quais possui génese humana. Todavia, em determinadas condições meteorológicas, também podem ocorrer incêndios com origem natural, decorrentes da existência de trovoadas secas.Os incêndios de junho do ano de 2017, pelas suas proporções e consequências, alimentaram acesa polémica em relação às hipóteses colocadas como causa, tendo-se apontando, frequentemente, a ação criminosa como sendo a justificação mais plausível. Sendo assim, para que os infratores pudessem ser punidos, tornava-se imperioso apurar as causas efetivas, tarefa que teria de ser realizada por investigadores devidamente credenciados para apurar este tipo de crime, de modo a que os resultados viessem a ser conclusivos.Assim, aplicando uma metodologia adequada, cujo princípio tem como objetivo geral a delimitação da área de início do incêndio florestal e, nesse reduzido espaço, a determinação do meio de ignição utilizado (que indicará o ponto de início) ou, na ausência deste, a pesquisa de evidências do exato ponto de eclosão/início, é possível obter conclusões sobre as causas dos incêndios. Dão-se exemplos da aplicação desse método a alguns dos grandes incêndios de junho de 2017 e apontam-se os resultados obtidos para a causa de cada um deles.
Synthesis and Characterization of Certain Photoactive Liquid Crystalline Poly(ester amides) from 2,5-Pyridine Dicarboxylic Acid
Authors: Chitra V. , Roopsingh D.
Published: March 2019

A new series of four photo-crosslinkable thermotropic liquid crystalline poly(ester amides) were synthesized by direct polycondensation of 2,5-pyridine dicarboxylic acid with two different varying diols and diamines. Two diamines employed in the synthesis were 4,4′-diaminodiphenyl methane and 1,4-diaminobenzene. The arylidene diols 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone and 2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone were also used. The synthesized poly(ester amides) were characterized by qualitative solubility test, FT-IR, 1H and 13C NMR spectra. The monomeric moieties were found to be well incorporated in the polymer back bone. The molecular weight of the polymer was assessed by gel permeation chromatography (GPC). The thermal phase transition behavior and liquid crystallinity of the poly(ester amides) were investigated by differential thermogravimetry (DTG) and hot stage optical polarized microscopy (HOPM), respectively. Interestingly, these poly(ester amides) in dimethylacetamide were found to possess photo-crosslinking characteristics when irradiated by UV light. These polymeric materials may find utility value in optical information storage devices.
Synthesis, Electronic Spectral Study and Antifungal Evaluation of Mixed Ligand Complexes
of Dibasic Tridentate Schiff Base and Naphthoic Acid with Transition Metal Ions
Authors: Verma Mukti , Verma Moni , Tarannum Nazia
Published: March 2019

Transition metal complexes of Mn(II), Co(II) and Cu(II) with dibasic tridentate Schiff base derived from the condensation of thiosemi-carbazide with acetoacetanilide as primary ligand and 1-hydroxy-2-naphthoic acid as co-ligand have been synthesized. The mixed ligand complexes of the above mentioned metal ions were characterized by analytical, magnetic and electronic spectral study. The transition metal complexes were also evaluated for antifungal activity against Drechslera tetramera, Fusarium oxysporum and Aternaria alternata at different concentrations.
Study of Blended Waste Organic Extracts in Wastewater Treatment
Authors: Veeramalini J.B. , Bharathiraja B. , Vinayak S. Raghu , Vignesh R. , Raghul S.K.
Published: March 2019

In present work, water treatment processes is carried out by an affordable, readily usable and non-chemical method. This study involved the process of water may reduce the concentration of particulate matter that includes suspended particles, micro organisms, a range of dissolved and particulate material derived from the surfaces. The substances used in this work were coarsely blended with each other and a special composite fibre filter was made. Several processes variables of quality of waste are also measured before and after the treatment. Results show that the water quality has been enriched in several ways such as reduction in the dissolved solids, pH has been controlled, deodorization and prevention of microbial growth. Hence use of this work has been utilized as a “Homemaker Model” and act as an alternative method for wastewater treatment in a cost effective way.
Box-Behnken Experimental Design for Extraction of Spinosin from Ziziphus mauritiana Lam. Seeds
Authors: Tran Quang Thuong , Thanh Vu Loan Thi , Le Tram Huyen , Phuong Giang Ly Thi , Usuki Toyonobu
Published: March 2019

The objective of this study was to evaluate the effects of extraction parameters (ethanol concentration, extraction ratio of solvent to raw material and extraction time) on the yield of spinosin from the seeds of Ziziphus mauritiana Lam. Box-Behnken factorial design was used in association with response surface methodology. The optimal extraction conditions were an ethanol concentration of 61 %, 40 (v/w) liquid-to-solid ratio, and 2.6 h extraction time with reflux. Spinosin was purified using Diaion HP20SS as an adsorbent. The maximum spinosin yield was 1.18 mg/g raw material. Present findings can be applied to future approaches for maximizing the extraction of spinosin from Z. mauritiana Lam. seeds.
Effect of Magnetic Treatment on Temporary Hardness of Groundwater
Authors: Alomari Abdulaziz Ali
Published: March 2019

The magnetic treatment devices for water have been in use for scale prevention several decades ago. Although, the effect of magnetic treatment on the chemical and physical properties of water is not fully understood and needs to make a lot of research effort to be clarified. This work aims to investigate the effect of the magnetic treatment on the temporary hardness of the groundwater. A sample of groundwater was passed twice under the influence of perpendicular magnetic strength 0.5 Tesla with a flow rate of 10 L/h. The temporary and permanent hardness as well as scale formation test were measured before and after the magnetic treatment. The scale was analyzed by XRD and SEM techniques. The temporary hardness and the weight of scales were reduced after the magnetic treatment by 39.1 and 22.3 %, respectively. The decrease of temporary hardness after the magnetic treatment of groundwater may be attributed to that the magnetic field reduces both the dissolved CO2 content and surface tension, both of which reduce the amount of temporary hardness. The SEM micrographs illustrate that the magnetic treatment modified the shape and size of crystals of CaCO3 scales to prevent its adhesion to the substrate forming hard scales. The XRD patterns prove that the magnetic treatment of groundwater enhances the crystallization of amorphous CaCO3 favouring the formation of calcite.
Interaction of Lorazepam with Planar Bilayer Lipid Membrane and Development of Impedimetric Sensor
Authors: Sivakumar S. , Rameshkumar S. , Sathishkumar S. , Sankar A.
Published: March 2019

Artificial planar bilayer phospholipid membrane was formed in KCl bath solutions and its electrical properties have been analyzed using electrochemical impedance spectroscopy. The stability of planar bilayer lipid membrane depends on concentration of KCl in the bath. Changes in the electrical properties of planar bilayer lipid membrane with the addition of lorazepam were also studied using electrochemical impedance spectroscopy. Lorazepam gets partitioned into bilayer lipid membrane and exhibited a fluidization effect. The ionic conductance across the bilayer lipid membrane increased with the addition of lorazepam to the bath. An impedimetric sensor was developed for quantification of lorazepam in solution.
Catalytic Hydrogenation Products of Aromatic and Aliphatic Dicarboxylic Acids
Authors: Shinde Sunil B. , Deshpande Raj M.
Published: March 2019

Hydrogenation of aromatic dicarboxylic acids gave 100 % selectivity to respective cyclohexane dicarboxylic acid with 5 % Pd/C catalyst. 5 % Ru/C catalyst was observed to give over hydrogenation products at 493 K and at lower temperature (453 K) the selectivity for cyclohexane dicarboxylic acids was increased. Hydrogenation of phthalic acid with Ru-Sn/Al2O3 catalyst was observed to give phthalide instead of 1,2-benzene dimethanol or 2-hydroxy methyl benzoic acid. Ru-Sn/Al2O3 catalyst selectively hydrogenated the carboxylic group of cyclohexane dicarboxylic acids to give cyclohexane dimethanol. Use of proper catalysts and reaction conditions resulted in desired products.
Diversity structure of phytoseiid mites in urban plant habitats
Authors: Grabovska S. L. , Mykolaiko I. I. , Mykolaiko V. P. , Myronyuk T. M.
Published: March 2019

We founded that E. finlandicus and K. aberrans formed the nucleus of Phytoseiidae community on the plants of urbanized environment in the result of study of 93 plant species (55 species of tree-and-shrub (58.9%) and 38 species of herbaceous plants (41.1%). Our research was carried out in plantations along the main and secondary municipal highways, near residential area and industrial buildings, on private plots of the private building area, in city parks and squares of Kyiv, Uman, Brovary, and Vasylkiv (Ukraine). The peculiarities of their distribution among urban plant associations, which differ from each other by different characteristics (population, area, degree of urbanization) were determined. Both species - E. finlandicus and K. aberrans have a rather extended range of indicators of relative biotope contiguity (-0.91<Fij<0.43 and -0.93Fij<0.96) that indicated their property to inhabit large number of plants. The indicator of K. aberrans occurrence, which was the highest in the city with the smallest degree of urbanization (Vasylkiv), decreased in the city with the maximum possible degree of urbanization (Kyiv). This indicator of E. finlandicus on the contrary increased along the gradient from a smaller city to the metropolitan city. K. aberrans inhabit a large number of plant species (33 species), while preferred plants from Rosacea family. E. finlandicus dominated by number of urban plant species it inhabited (75 species, 79.78%), absolute number of individuals in collected samples of predatory mites (504), occurrences index (Is = 74.49%), and by index of Palii-Kovnatsi (Di = 51.42%). The dominance of E. finlandicus species was registered in both groups of plants. The distribution of Phytoseiidae’s was primarily connected with the possibility of their movement along the surface of the substrate. Speed of mites moving was not the same in different species and depended on their morphology and plant morphology. Both species lived and laid eggs on the underside of the leaf. K. aberrans was more commonly found near the central vein of the leaf, while E. finlandicus was observed more evenly on the leaf plate, which can be explained by it higher vagility. K. aberrans could inhabit high number on fruit varieties of plants with pubescence leaves. Morphological features of plant leaves did not affect the spread of E. finlandicus species, therefore, they could be considered more "universal". However, it reached a higher quantity on the plants with a smooth surface of a leaf plate. Certain temperature, illumination regime, air and soil humidity caused the differences in mites spreading at various habitats.
Sensefield: An Exhibition of Experimental Ethnography
Authors: De Seta Gabriele , Friedman Kerim
Published: March 2019

This project report describes Sensefield: An Exhibition of Experimental Ethnography, an event showcasing works at the intersection of art and anthropology held in October 2017 in Taipei, Taiwan.
On One Theorem of S. Warschawski
Authors: Abdulaev R.
Published: March 2019

A theorem of S. Warschawski on the derivative of a holomorphic function mapping conformally the circle onto a simply-connected domain bounded by the piecewise-Lyapunov Jordan curve is extended to domains with a non-Jordan boundary having interior cusps of a certain type.
Inversion of the Cauchy Integral Taken over the Double Periodic Line
Authors: Khatiashvili N.
Published: March 2019

The Cauchy type singular integral equation is investigated when the line of integration is the union of a countable number of disconnected segments. The equation is equivalently reduced to an equation with double periodic kernel. Effective solutions having integrable singularities at the end-points of the line of integration are obtained.
Investigation of Two-Dimensional Models of Elastic Prismatic Shell
Authors: Avalishvili M. , Gordeziani D.
Published: March 2019

Statical and dynamical two-dimensional models of a prismatic elastic shell are constructed. The existence and uniqueness of solutions of the corresponding boundary and initial boundary value problems are proved, the rate of approximation of the solution of a three-dimensional problem by the vector-function restored from the solution of a two-dimensional one is estimated.
On Some Convexity Properties of Generalized Cesáro Sequence Spaces
Authors: Suantai Suthep
Published: March 2019

We define a generalized Cesáro sequence space and consider it equipped with the Luxemburg norm under which it is a Banach space, and we show that it is locally uniformly rotund.
On the Oscillation of Solutions of First Order Differential Equations with Retarded Arguments
Authors: Grammatikopoulos M. K. , Koplatadze R. , Stavroulakis I. P.
Published: March 2019

For the differential equation

where 𝑝𝑖 ∈ 𝐿
loc
(𝑅+; 𝑅+), τ
𝑖 ∈ 𝐶(𝑅+; 𝑅+), τ
𝑖(𝑡) ≤ 𝑡 for 𝑡 ∈ 𝑅+, , optimal integral conditions for the oscillation of all solutions are established.
Combinatorial Homology in a Perspective of Image Analysis
Authors: Grandis Marco
Published: March 2019

This is the sequel of a paper where we introduced an intrinsic ho-motopy theory and homotopy groups for simplicial complexes. We study here the relations of this homotopy theory with the well-known homology theory of simplicial complexes. Also, our investigation is aimed at applications in image analysis. A metric space 𝑋 representing an image, has a structure of simplicial complex at each resolution ε > 0, and the corresponding combinatorial homology groups
give information on the image. Combining the methods developed here with programs for automatic computation of combinatorial homology might open the way to realistic applications.
Reading Forensics: La Biblioteca Roja: Brevísima relación de la destrucción de los libros
Authors: Shackelford Laura
Published: March 2019

Extending recent media archaeological preoccupations, this essay examines the Argentine excavation project and art book, La Biblioteca Roja: Brevísima relación de la destrucción de los libros (2017), and suggests the particular importance of such comparative “(an)archaeological” inquiries into the technical systems essential to knowledge cultures and their evidential power regimes today. Combining multiple media and interdisciplinary methods—from visual drawings, essays, personal reflection, interviews, cultural analysis, forensic science, photographic documentation, and small press publishing—La Biblioteca Roja is a compelling experiment in dissident memory, as well as artifactual storytelling. The essay stresses its relevance as a rupture and intervention in current digitally informed, bioinformatic technical systems and knowledge cultures, and inquiries into continuities as well as differences between the technical systems of book cultures and more contemporary digital knowledge cultures, particularly with regard to their efforts to secure and territorialize knowledge and power through technical means that erase, destroy, and dismiss other knowledges and through them, other modes of life.
KÖK HÜCRELER VE DİŞ HEKİMLİĞİ: LİTERATÜR DERLEMESİ
Authors: Topsakal Kübra Gülnur , Korkmaz Yasemin Nur
Published: March 2019

Kök hücreler, hem rejeneratif tıp uygulamalarında
hem de doku rejenerasyonunda kullanılan ve dental dokular da dahil olmak üzere
çok çeşitli doku ve organlardan izole edilen prekürsör hücrelerdir. Hem doku
mühendisliğinde hem de klinik uygulamalarda kullanılan kök hücreler,
odontoblastlardan nöral hücrelere kadar birçok hücreye dönüşebilme yeteneğine
sahiptir. Diş hekimliği alanında yetişkin mezenkimal kök hücreler çeşitli oral
ve maksillofasiyal dokularda tanımlanmıştır; bu da oral dokuların kök
hücrelerden zengin olduğunu ve mukozal hücrelerin indükte pluripotent kök
hücreler gibi genetik olarak yeniden programlanmış hücreler için ideal kaynak
olabileceğini göstermiştir. Ayrıca oral dokuların kök hücreler için yalnızca
bir kaynak değil, aynı zamanda terapötik bir hedef olması da beklenmektedir. Bu
derlemede, diş hekimliği alanındaki klinik kullanılabilirlik ve uygulamalar
açısından çeşitli intra ve ekstraoral doku kökenli kök hücre tiplerine ve
rejeneratif diş hekimliği için uygun kök hücrelere genel bir bakış açısı
sunulmaktadır.
Üniversal adezivlerin vital beyazlatma yapılmış dişlerde bağlanma dayanımına etkisi
Authors: UÇAR Ebru Nur , ARSLAN Soley , DEMİRBUĞA Sezer , ÇAYABATMAZ Muhammed
Published: March 2019

Amaç: Bu çalışmanın amacı
hidrojen peroksit içerikli vital beyazlatma uygulamasını takiben uygulanan
universal bir adeziv sistemin mineye mikro makaslama bağlanma dayanımı
kuvvetinin değerlendirilmesidir.Gereç ve Yöntemler:Bu amaçla, çekilmiş 60
mandibular premolar dişin düzleştirilmiş labiyal mine yüzeylerine % 40 hidrojen
peroksit içeren jel (Opalescence Boost) uygulanmıştır. Yapay tükürük içerisinde
iki haftalık bekleme süresini takiben dişler uygulanacak adeziv sistemlere göre
4 gruba ayrılmıştır (n=15); Single Bond Universal (etch&rinse modunda) (SBUE)
(3M ESPE), Single Bond Universal (self-etch modunda) (SBUS), One Step (OS)
(Bisco),  Adper Easy One (AEO) (3M ESPE).
Mine yüzeylerine adeziv sistemlerin uygulanmasını takiben tygon tüpler ile
kompozit rezin materyal yerleştirilmiş ve mikro makaslama bağlanma dayanımı
testi gerçekleştirilmiştir. Kopma yüzeyi ve kırılma tipleri SEM ile
incelenmiştir. Bulgular: SBUE hem kendi kontrol
grubuna oranla (SBUS) hem de diğer tüm gruplara göre istatistiksel olarak
anlamlı ölçüde yüksek bağlanma değerleri sunmuştur (p<0.05). Bunu sırasıyla
OS, SBUS ve AEO grupları takip etmiştir. Sonuçlar: Hidrojen peroksit ile
vital beyazlatma işlemi sonrasında uygulanan üniversal adeziv etch&rinse
sistemde uygulandığında daha yüksek mikro makaslama bağlanma dayanımı gösterir.Anahtar Kelimeler: Bağlanma dayanımı,
beyazlatma, etch&rinse, üniversal adeziv
Monostotik Mandibular Fibröz Displazi: Olgu Sunumu
Authors: Çebi Ahmet Taylan , İla Kadri , Yılmaz Nihat
Published: March 2019

Fibröz
displazi sıklıkla çocuk yaşlarda ve ergenlerde görülen; kemiğin gelişimsel,
yavaş büyüyen, fibroosseöz benign bir lezyonudur. Fibröz displazi bir ya da
birden çok kemiği etkiliyebilir.  Fibröz
displazi klinik olarak ikiye ayrılır ve bunlar monostotik ve poliostotik fibröz
displazi olarak adlandırılırlar. Radyografik görüntüsünde, displazik lezyon
içindeki artan kemik oluşumunda birlikte 'buzlu cam' veya 'portakal kabuğu'
görüntüsünü andırmaktadır. Bu olgu sunumunda klinik, radyografik ve
histopatolojik incelemelerle tanısı koyulmuş fibröz displazi olgusu sunulmuştur.
“Sabit Ortodontik Tedavinin ilk Üç Ayında Gözlenen Kilo Kaybı ve Beslenme Değişiklikleri”
Authors: KILINÇ Delal Dara , SAYAR Gülşilay
Published: March 2019

Amaç: Sabit ortodontik tedavinin ilk üç ayında beslenme, beslenme değişiklikleri ve kilo değişimini değerlendirmek.Gereç ve Yöntem: Sabit ortodontik tedaviye ihtiyaç duyan 53 hasta (13 erkek, 41 kadın) seçildi. Benzer koşullara sahip 50 birey(14 erkek ve 36 kadın) kontrol olarak seçildi. Kontrol grubunda yaş ortalaması 17.44 ± 0.75, tedavi grubunda 17.67 ± 0.85 idi. Tedavi başlangıcında, braketleme sonrası 1. hafta ve 1., 2. ve 3. ay düzenli şekilde hastaların kilo değerleri kaydedildi. Aynı değerler kontrol grubu için de kaydedildi. Tedavi grubuna tedavinin ilk ayında diyet değişikliklerini kaydetmesi için bir anket uygulandı.Bulgular: Tekrarlanan Varyans Analizi sonuçlarına göre zaman bağımlı değişmeler istatistiksel olarak anlamlıydı (p: 0.015), ancak Zaman-Grup etkileşimi sonuçları istatistiksel olarak anlamlı değildi (p: 0.051). Başlangıç ​​değerleri ile 1. hafta ve 1. ay değerleri arasındaki zaman aralıklarına göre ağırlık değerleri arasında istatistiksel olarak anlamlı fark vardı; diğer zaman aralıkları arasında istatistiksel olarak anlamlı bir fark yoktu. Tedavi grubunun ortalama ağırlık değerlerinde, ortalama başlangıç ​​değerlerine göre istatistiksel olarak önemli bir düşüş vardı. Sonuçlar: Tedavinin ilk ayında kayda değer diyet değişiklikleri ve klinik olarak gözle görülür kilo kaybı tedavi gurubundaki tüm hastalarda gözlendi. Tedavinin ikinci ayından sonra hastalar tekrar kilo almaya başladılar.
Üst Çenede Çift Taraflı Gömülü Köpek Dişi-Birinci Küçük Azı Transpozisyonu ve Yan Keser Diş Eksikliğinin Multidisipliner Tedavisi Multidisciplinary Treatment of Bilateral Maxillary Impacted Canine- First Premolar Transposition and Lateral Incisor Agenesis
Authors: ULUSOY MUTLUOL Esra
Published: March 2019

Ön bölgedeki diş eksiklikleri ve transpozisyonlar
stratejik konumlarından dolayı ciddi estetik ve fonksiyonel problemlere neden
olmaktadır. Estetik ve fonksiyonel başarının sağlanması ancak doğru tanı ve
uygulamalara bağlıdır. Bu olgu raporunda, üst çenede çift taraflı gömülü köpek
dişi birinci küçük azı dişi transpozisyonu ve yan keser diş eksikliği olan 13
yaşında bir bayan hasta anlatılmaktadır. Ortodontik tedavi planı birinci küçük
azı dişlerinin yan keser diş alanına taşınması, gömülü dişlerin sürdürülmesi ve
alt birinci küçük azı dişlerinin çekilmesidir. Gömülü dişler 1 yıl 4 ayda
sürdürülmüştür ve daha sonrasında birinci küçük azı dişleri yan keser dişlere
benzetilecek şekilde aşındırılıp restoratif tedavi yapılmıştır. Ortodontik
tedavi 2 yıl 8 ayda tamamlanmıştır.

Anahtar
Kelimeler: Diş eksikliği, transpozisyon, ortodonti

Agenesis and tooth transposition in the anterior
region cause serious esthetic and functional problems
due to
their strategic location. The esthetic and functional success depends on the
correct diagnosis and clinical procedures. 
In this case report 13-year-old female with bilateral maxillary impacted
canine-first premolar transposition and lateral incisor agenesis. Orthodontic
treatment plan involved orthodontic traction of bilaterally impacted canine
after providing adequate space, orthodontic movement of first premolar tooth
into lateral incisor sides and extraction lower bilateral first premolar. The
impacted tooth were erupted and aligned in 1 year and four months and then the
first premolars were stripped in order to mimic a lateral incisor. Orthodontic
treatment was completed in 2 years and 8 months.

 

Keywords: Agenesis,
transposition, orthodontics
Mortalidad por enfermedades digestivas no neoplásicas en la población adulta del Perú, 2010 – 2015
Authors: Castillo-Contreras Ofelia , Flores-Flores Claudio
Published: March 2019

Introducción. Las enfermedades digestivas (ED) no neoplásicas son causas importantes de consulta médica y hospitalización. Objetivo. Determinar la mortalidad por ED no neoplásicas en la población adulta del Perú entre 2010 y 2015. Métodos. Análisis secundario del registro de defunciones por ED no neoplásicas en la población mayor de 18 años entre los años 2010 y 2015 de la Oficina General de Estadística e Informática del Ministerio de Salud del Perú. La población para el mismo periodo se obtuvo del Instituto Nacional de Estadística e Informática. Se calcularon las tasas de mortalidad estandarizada (TME x 100 000 personasaño). Resultados. Durante el período 2010-2015 se registraron 39 889 muertes por ED no neoplásicas. Las TME más altas fueron para el grupo de las enfermedades del hígado (12,2 x 100 000 personas-años), siendo la fibrosis y cirrosis del hígado la de mayor mortalidad (9,1). La pancreatitis aguda (1,0) tuvo mayor TME que la úlcera gástrica (0,7). Las TME, según las regiones del Perú, fueron altas por fibrosis y cirrosis del hígado en Piura (16,3), Lambayeque (14,6) y La Libertad (14,4); por colelitiasis (1,1) y colecistitis aguda (1,7), en Puno; por pancreatitis aguda (2,2), en Tacna; y por úlcera gástrica fue mayor en Huancavelica (3,6) y Huánuco (2,3). Conclusiones. La fibrosis y cirrosis del hígado fue la ED no neoplásica con mayor tasa de mortalidad en la población adulta del Perú, principalmente en la costa norte del país.
Guía de práctica clínica basada en evidencias para el tratamiento de depresión en adultos en un hospital especializado en salud mental. Lima, Perú
Authors: Vargas Cajahuanca Gisella , Gallegos Cazorla Carolina , Salgado Valenzuela Carlos , Salazar de la Cruz Miriam , Huamán Sánchez Karen , Bonilla Untiveros Catherine , Reyes Puma Nora , Caballero Ñopo Patricia
Published: March 2019

Introducción. La depresión es un trastorno mental que en su forma más grave puede terminar en el suicidio. Objetivo. La presente guía de práctica clínica basada en evidencias (GPC-BE) brinda recomendaciones para el tratamiento farmacológico y psicoterapéutico de la depresión en adultos. Métodos. Se elaboró una GPC-BE adaptada mediante un proceso sistemático, riguroso y transparente con un grupo elaborador conformado por metodólogos y psiquiatras expertos en el manejo de la enfermedad. La guía cuenta con siete preguntas clínicas y 10 recomendaciones; se realizó la búsqueda y preselección de GPC que respondan al alcance y objetivos planteados, las mismas que fueron evaluadas mediante el instrumento “Appraisal of Guidelines for Research and Evaluation II” (AGREE-II), seleccionándose la guía de mejor calidad metodológica para su adaptación. La búsqueda sistemática de evidencias para responder las preguntas clínicas se realizó en múltiples bases de datos: MEDLINE/PubMed, EMBASE/Ovid, Cochrane Library, LILACS y SciELO. Las evidencias fueron seleccionadas y analizadas críticamente por pares clínicos y metodológicos, las recomendaciones fueron elaboradas mediante la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Resultados. Con la participación de un panel de expertos clínicos de diferentes hospitales de referencia en el manejo de depresión, se elaboraron 10 recomendaciones dirigidas al inicio del tratamiento farmacológico y psicoterapéutico, la terapia combinada, psicoterapia individual-grupal, y eventos adversos de la farmacoterapia en los pacientes adultos con depresión. Conclusiones. El presente artículo es un resumen de la guía de práctica clínica basada en evidencias para el tratamiento de depresión en adultos para un hospital público peruano especializado en salud mental.