bluuebunny/crossref_metadata_2025 huggingface dataset:
Debranching-first followed by aortic arch replacement with frozen elephant trunk
Authors: Suzuki Ryo , Akita Masafumi , Miyazaki Suguru , Shimano Ryo
Published: April 2023

Background: Diffuse thoracic aortic aneurysm has been a challenge for cardiovascular surgeons as aortic arch and descending aortic aneurysm should be treated simultaneously somehow. The total arch replacement (TAR) using a frozen elephant trunk (FET) allows them to treat aortic arch and descending aortic pathology at once via median sternotomy. Besides, extra-anatomical bypass performed between the left common carotid artery (CCA) and subclavian artery (SCA) prior to TAR allowed further proximalization of FET prosthesis and facilitated distal anastomosis of TAR and spared the demanding Left subclavian artery (LSA) anastomosis in deep pericardial space.
We investigated the efficacy of this debranching-first technique followed by total arch replacement using a frozen elephant trunk as a two-stage operation for extensive thoracic aortic aneurysm among high-risk patients.
Methods: Forty-nine consecutive patients with diffuse degenerative aneurysms from the aortic arch to the descending aorta or chronic aortic dissection receiving left common carotid to subclavian artery bypass followed by total arch replacement using a frozen elephant trunk and possible subsequent thoracic endovascular aortic repair between 2016 and 2021 were analysed. The baseline characteristics and clinical outcomes were demonstrated. Overall survival rate and 5-year aortic event-free survival, aortic reintervention rates were analysed.
Results: The average score of European System for Cardiac Operative Risk Evaluation (EuroSCORE II) was 4.7±2.5. The operative mortality rate was 4.1%, with no paraplegia events. The five-year overall survival, cumulative aortic related mortality were 76.8%, 2%, respectively. The five-year overall cumulative aortic reintervention rates including intended intervention were 31.3%. The 5-year cumulative rate of non-intended reintervention was 4.5%.
Conclusions: The assessed technique enables a less invasive and less technically demanding surgery with reasonable outcomes. The 5-year aortic event-free survival and reintervention rates were acceptable, suggesting that multiple stages of alternative open and endovascular interventions, such as this technique, may reduce the morbidity and mortality rates of high-risk patients with diffuse thoracic aortic aneurysm.
Clinical registration number: 2022001
Therapeutic yield of extensive molecular profiling in cholangiocarcinoma: a retrospective single center study.
Authors: Vancanneyt Justine , Wilmsen Bie , Luyten Caroline , Verslype Chris , Cutsem Eric , Roskams Tania , Tejpar Sabine , Bempt Isabelle Vanden , Dekervel Jeroen
Published: April 2023

Introduction: Current available systemic therapies for advanced cholangiocarcinoma (CCA) are of limited effectiveness and prognosis is poor. Recently, introduction of next-generation sequencing (NGS) technologies led to a better understanding of the genetic pathophysiology and consequently, identification of molecular alterations for targeted treatment.
Aim: To determine the proportion of actionable alterations using extensive molecular profiling in a routine diagnostic setting and to study the effect of targeted treatment on disease control.
Methods: Results of extensive molecular testing by either FoundationOne NGS or an in-house developed 96 cancer gene panel were retrospectively collected from patients with locally advanced or metastatic CCA diagnosed between 01/12/2018 and 01/08/2021 in a single center. Gene variants were classified according to ESCAT and correlated with efficacy endpoints.
Results: Of 125 patients included, 65 patients had an intrahepatic CCA (iCCA).
FGFR2 fusions and IDH1/BAP1 mutations were more frequent in iCCA, while KRAS and SMAD4 mutations were predominant in extrahepatic CCA (eCCA). Targetable alterations (ESCAT tiers I-IV) were identified in 73,6% of patients. Overall survival was significantly better for higher tiers regardless of treatment.
Thirteen patients (10.4%) received targeted treatment based on molecular profiling, with a median progression free survival (PFS) of 7,3 months.
Conclusions: Extensive molecular characterization led to the identification of targetable and potentially targetable alterations in a significant proportion of patients with locally advanced or metastatic CCA.
We confirmed the association between higher ESCAT tier and benefit of a targeted treatment.
Molecular analysis should therefore be considered in all patients fit enough for systemic treatment.
Some applications of renormalization group to few-body problems in EFT
Authors: Mindadze Bidzina , Epelbaum Evgeny , Gegelia Jambul
Published: April 2023

General aspects of applying renormalization group in perturbative calculations are briefly discussed. Next, an application of the Wilsonian renormalization group with multitude of cutoff parameters to halo EFT for P-wave shallow states is considered.
IRFSC: A high-efficiency hybrid model Image Retrieval Based on Feature Selection Using Continuous Learning Process
Authors: Lande Milind Vijayrao , Ridhorkar Sonali
Published: April 2023

Design of high-efficiency feature representation and ranking models is required for retrieval of images based on colour, texture, shape, and other visual aspects. These models must be able to increase retrieval precision while reducing the amount of error and delay required for ranking procedures. Low complexity models can run more quickly, but they are limited in their retrieval performance because they do not exhibit higher retrieval rates. This essay suggests designing a novel hybrid model for high-efficiency feature selection-based picture retrieval using a continuous learning approach to address these problems. A hybrid Elephant Herding Optimization (EHO) & Particle Swarm Optimization (PSO) layer is used in the model's initial extraction of large feature sets from multimodal images in order to continually maximize inter-class feature variance levels. These ranks are post-processed using an incremental optimization method based on Q-Learning, which supports in the continuous optimization of image data sets. As compared to recently proposed state-of-the-art models, the suggested model is able to preserve reduced delay while improving retrieval accuracy by 0.07%, precision by 10.5%, and recall by 3.60%. As a result, the proposed model can be used for a wide range of real-time use cases.
Optimal pension fund management with stochastic additional contribution rate in a defined contribution pension plan
Authors: Nkeki Charles , Ibe C. B.
Published: April 2023

This paper examines an optimal pension fund management in which a pension plan member (PPM) make a flow of contributions that comprises of two parts: mandatory contribution with fixed contribution rate, and additional voluntary contribution (AVC) with stochastic contribution rate. The mandatory part is a fixed fraction of a PPM's stochastic salary while the latter part is assume to be stochastic with contribution growth rate (CGR) and volatility depending on the contribution rate, the salary and the wealth processes of a PPM over time. The sum of the two contribution rates make up the total stochastic contribution rate of a PPM. Two asset classes are consider: the risky and the riskless assets. The latter pays a stochastic interest rate that follows uncontrolled Vasisek model. Also, it is assume that the PPM consume some portion of his or her wealth continuously over time. This paper aims at determining the optimal investment, optimal consumption rate, the optimal contribution rate and effect of AVC rate on the investment portfolio. The optimal investment portfolio, optimal contribution rate, optimal consumption rate and explicit expression of the CGR of a PPM's contribution rate are obtained. We found that the investment portfolio depend inversely on the contribution rate and the interest rate, and directly on the contribution of a PPM. The intertemporary hedging portfolio strategies with respect to contribution rate, contribution process and interest rate are obtained. Furthermore, we found that the CGR depend on the optimal wealth, optimal contribution rate, interest rate, salary, investment risk, salary risk, contribution risk, interest rate risk, and coefficient of constant relative risk averse of a PPM. We also found that the CGR depend directly on the salary and the contribution processes and inversely on the contribution rate and interest rate of a PPM over time. Also, we found that the CGR react to changes in the salary process and its risk, wealth process, contribution rate and contribution risk, interest rate and interest rate risk, and coeffecient of risk averse.
Electrodermal and central measures of the phasic orienting reflex (OR)
Authors: Barry Robert J. , Steiner-Lim Genevieve Z. , Cave Adele E. , De Blasio Frances M. , MacDonald Brett
Published: April 2023

Although the P300 event-related potential (ERP) is the most likely central measure of Sokolov’s Orienting Reflex (OR), there are few systematic comparisons with the skin conductance response (SCR), the “gold standard” electrodermal OR measure. We examine habituation, stimulus significance, and inter-stimulus interval (ISI) effects in SCRs and components of the P300 from single-trial ERPs in an auditory dishabituation paradigm. Single trial ERP components were separated by temporal principal components analysis, and five components of the P300 were examined as potential phasic OR measures: P3a, P3b, Novelty P3, and two Slow Waves (SW1, SW2). Across the factors of ISI and significance, SCRs showed decrement over trials, recovery at a deviant, and dishabituation at the subsequent standard. This general pattern was not present in any of the components of the P300. SCRs were also larger to significant stimuli and at the long ISI; effects differed between P300 components. The electrodermal SCR showed the complete profile over trials expected of the phasic OR, and was enhanced by stimulus significance, confirming it as the model measure of Sokolov’s phasic OR. Components of the P300 failed to match this profile, but instead appear to reflect different aspects of the stimulus processing involved in OR elicitation.
Association between SARS-CoV-2 variants and post COVID-19 condition: findings from a longitudinal cohort study in the Belgian adult population
Authors: Nguyen Huyen Thi Khanh , Laura Cornelissen , Diego Castanares-Zapatero , De Pauw Robby , Cauteren Dieter Van , Stefaan Demarest , Sabine Drieskens , Devleesschauwer Brecht , De Ridder Karin , Charafeddine Rana , Smith Pierre
Published: April 2023

Background: While many studies on the determinants of post-COVID-19 conditions (PCC) have been conducted, little is known about the relationship between SARS-CoV-2 variants and PCC. This study aimed to assess the association between different SARS-CoV-2 variants and the probability of having PCC three months after the infection.
Methods: This study was a longitudinal cohort study conducted between April 2021 and September 2022 in Belgium. In total, 8,238 adults with a confirmed SARS-CoV-2 infection were followed up between the time of their infection and three months later. The primary outcomes were the PCC status three months post infection and seven PCC symptoms categories (neurocognitive, autonomic, gastrointestinal, respiratory, musculoskeletal, anosmia and/or dysgeusia, and other manifestations). The main exposure variable was the type of SARS-CoV-2 variants (i.e. Alpha, Delta, and Omicron), extracted from national surveillance data. The association between the different SARS-CoV-2 variants and PCC as well as PCC symptoms categories was assessed using multivariable logistic regression.
Results: The proportion of PCC among participants infected during the Alpha, Delta, and Omicron-dominant periods was significantly different and respectively 50%, 50%, and 37%. Participants infected during the Alpha- and Delta-dominant periods had a significantly higher odds of having PCC than those infected during the Omicron-dominant period (OR = 1.61, 95% confidence interval [CI] = 1.33–1.96 and OR = 1.73, 95%CI = 1.54–1.93, respectively). Participants infected during the Alpha and Delta-dominant periods were more likely to report neurocognitive, respiratory, and anosmia/dysgeusia symptoms of PCC.
Conclusions: People infected during the Alpha- and Delta-dominant periods had a higher probability of having PCC three months after infection than those infected during the Omicron-dominant period. The lower probability of PCC with the Omicron variant must also be interpreted in absolute figures. Indeed, the number of infections with the Omicron variant being higher than with the Alpha and Delta variants, it is possible that the overall prevalence of PCC in the population increases, even if the probability of having a PCC decreases.
Perbandingan Algoritma K-Means dan K-Medoids Untuk Pemetaan Daerah Penanganan Diare Pada Balita di Kabupaten Kuningan
Authors: Syamfithriani Tri Septiar , Mirantika Nita , Trisudarmo Ragel
Published: April 2023

Diarrhea is an endemic disease that contributes to the high mortality rate in Indonesia, especially among children under five. The Kuningan District Health Office had difficulties in monitoring and supervising the spread of diarrheal diseases. This study aims to produce a mapping scheme of priority areas in handling the prevention and control of the spread of diarrheal disease in children under five in Kuningan Regency. The method used is the Data Mining Clustering method by comparing two algorithms, namely the K-Means algorithm and the K-Medoids algorithm. Determination of the optimum number of clusters using the Elbow and Silhouette Coefficient methods. With this method, the result is that in the K-Means algorithm the optimum number of clusters is 3 clusters while the K-Medoids algorithm is 2 clusters. The best cluster evaluation uses the Davies-Bouldin Index (DBI) method and the results show that the K-Means DBI value is always smaller than the K-Medoids algorithm in either 2 clusters or 3 clusters, this shows that the K-Means algorithm is better than the K-Medoids algorithm. Based on these results, it is recommended to map priority areas for handling diarrheal diseases using the K-Means algorithm with 3 clusters, namely medium priority areas consisting of 9 regions, high priority areas consisting of 3 regions and low priority areas consisting of 25 regions. The results of the mapping can be used as input for the Kuningan District Health Office to develop strategies for preventing and preventing diarrheal diseases in children under five.
Synthesis, characterization, biological studies and DFT study of Schiff Bases and their complexes derived from aromatic diamine compounds with cobalt (II)
Authors: Mohammed Abduljleel Abduljleel , Saleh Alshawi Jassim Mohammed , Ali Hussein kawkab , Ismael Sadiq M-H.
Published: April 2023

Based on vanillin and diamine compounds (ortho phenylene diamine, meta phenylene diamine, 3,4- diamine toluene), derivation of two new Schiff base ligands (L1 and L2) was done, after which synthesis and treatment with Co (II) chloride was performed at a metal-to-ligand ratio of 1:1 to get two new complexes, i.e. [CoL3(H2O)2]Cl2 and [CoL1(H2O)2]Cl2. These complexes and ligands were characterized by employing NMR, IR, atomic absorption, UV visible absorption, molecular weight determination, molar conductance, and magnetic measurement techniques. As per the data, the ligands were found to be bidentate ligands that were linked to two azomethine nitrogen sites. It was suggested that these complexes were paramagnetic electrolyte compounds that possessed coordination number four. Screening of the ligands and metal complexes was done to assess their antimicrobial activities against gram-negative and gram-positive bacteria, which was found to show biological activity. Calculations using quantum chemistry were done to examine the molecule geometry. The investigation includes several quantum chemical characteristics derived from frontier molecular orbitals.

Keywords: Schiff bases, transition metal complexes, vanillin, diamine aromatic compounds, antibacterial activity, DFT study.
Video Counseling and a Safety Planning App to Support Pregnant Women Exposed to Intimate Partner Violence in Denmark and Spain During COVID-19
Authors: Andreasen Karen , Linde Ditte S , Zapata-Calvente Antonella Ludmilla , Martín-de-las-Heras Stella , Megías Jesús López , Rasch Vibeke
Published: April 2023

Background

Isolation was a consequence of the COVID-19 lockdowns, which led to increased incidence of intimate partner violence (IPV). During antenatal care, it is possible to screen pregnant women for IPV; this offers a unique opportunity for early intervention. During the pandemic, we designed and implemented a digital IPV intervention tailored to pregnant women in Denmark and Spain.

Objective

This study aimed to identify pregnant women exposed to IPV through digital screening and offer video counseling as well as a safety planning app to those who screened positive.

Methods

Pregnant women attending antenatal care were screened for IPV through a digital questionnaire. Women who screened positive were offered 6 video consultations with an IPV counselor and provided with access to a dedicated safety planning app. In-depth interviews inspired by the Model for Assessment of Telemedicine Applications were conducted with counselors and participants. The intervention was cocreated with women who have been exposed to IPV, nongovernmental organizations, and health care providers.

Results

Despite the COVID-19 shutdowns, more than 15,000 pregnant women have been screened for IPV since January 2021. Qualitative interviews with women who completed the intervention as well as IPV counselors show broad acceptance of the video counseling, particularly the ability to participate from a safe environment and talk to a stranger about sensitive and stigmatizing issues. Preliminary findings show that both women and counselors find the video counseling highly supportive, empowering, and aligned with the needs for safety. The majority indicate improved well-being after the intervention, and neither counselors nor participants see video counseling as a barrier toward talking about sensitive topics such as IPV. The safety app was not perceived as effective.

Conclusions

The preliminary results show that video counseling conducted during the COVID-19 pandemic supports pregnant women exposed to IPV and is highly feasible and accepted in both Denmark and Spain.

Conflicts of Interest

None declared.
Effectiveness and Feasibility of a Self-guided Mobile App Targeting Emotional Well-being in Healthy Adults: 4-Week Randomized Controlled Trial
Authors: Brindal Emily , Kakoschke Naomi , Golley Sinead , Rebuli Megan , Baird Danielle
Published: April 2023

Background

Commercial smartphone apps designed to promote emotional well-being are becoming increasingly popular, but few apps have been empirically validated.

Objective

This study examined the feasibility and effectiveness of a self-guided app designed to reduce daily stress via positive messaging and tailored short inspirational talks (ie, peps).

Methods

A total of 166 participants (n=112, 67.5% female; mean age 38.48, SD 6.73 years) were recruited through social media advertising and randomized into an intervention (Hey Lemonade app plus twice daily mood monitoring using the Multidimensional Mood Questionnaire [MDMQ]) or active control (twice daily mood monitoring [MDMQ]) group. Primary (coping self-efficacy [CSE]; 3 subscales) and secondary outcomes (vitality, satisfaction with life, perceived stress, positive and negative affect, and hassles and uplifts) were measured at the baseline (week 1) and end point (week 4). The app evaluation questions were assessed at week 2. All interactions and measurements were collected on the internet and through the apps.

Results

In total, of 166 participants, 125 (75.3%) completed the trial. There were no differences in dropout rates between the groups (62/81, 76% intervention; 63/85, 74% control). There were significant group-by-time interactions for vitality and hassles but no significant effect for CSE total (P=.05). For the intervention group, the change from baseline to week 4 was significant for vitality (P=.002) and hassles (P=.004), CSE total (P=.008), and CSE Emotional subscale (P=.02). For the control group, any changes over 4 weeks were not significant for any outcome. There was a significant group-by-time interaction for MDMQ calmness (P=.04). By week 4, calmness was significantly higher in the intervention group (P=.046). Of those in the intervention group at week 2 (n=68), 39 (57%) participants recommended the app and 41 (60%) participants wanted to continue using it. Pep talks and customizable voice options were the most popular features.

Conclusions

Participants who had access to the smartphone app on an as-needed basis over the 4-week trial showed significant improvements in emotional well-being indicators. More broadly, this suggests that simple accessible solutions may generate meaningful well-being outcomes. Whether these changes are sustained and can be generalized to other population groups is yet to be determined.

Trial Registration

Australian and New Zealand Clinical Trials Registry (ANZCTR) 12622001005741; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=384304&isReview=true
An Ontology-Based Approach to Improving Medication Appropriateness in Older Patients: Algorithm Development and Validation Study
Authors: Calvo-Cidoncha Elena , Verdinelli Julián , González-Bueno Javier , López-Soto Alfonso , Camacho Hernando Concepción , Pastor-Duran Xavier , Codina-Jané Carles , Lozano-Rubí Raimundo
Published: April 2023

Background

Inappropriate medication in older patients with multimorbidity results in a greater risk of adverse drug events. Clinical decision support systems (CDSSs) are intended to improve medication appropriateness. One approach to improving CDSSs is to use ontologies instead of relational databases. Previously, we developed OntoPharma—an ontology-based CDSS for reducing medication prescribing errors.

Objective

The primary aim was to model a domain for improving medication appropriateness in older patients (chronic patient domain). The secondary aim was to implement the version of OntoPharma containing the chronic patient domain in a hospital setting.

Methods

A 4-step process was proposed. The first step was defining the domain scope. The chronic patient domain focused on improving medication appropriateness in older patients. A group of experts selected the following three use cases: medication regimen complexity, anticholinergic and sedative drug burden, and the presence of triggers for identifying possible adverse events. The second step was domain model representation. The implementation was conducted by medical informatics specialists and clinical pharmacists using Protégé-OWL (Stanford Center for Biomedical Informatics Research). The third step was OntoPharma-driven alert module adaptation. We reused the existing framework based on SPARQL to query ontologies. The fourth step was implementing the version of OntoPharma containing the chronic patient domain in a hospital setting. Alerts generated from July to September 2022 were analyzed.

Results

We proposed 6 new classes and 5 new properties, introducing the necessary changes in the ontologies previously created. An alert is shown if the Medication Regimen Complexity Index is ≥40, if the Drug Burden Index is ≥1, or if there is a trigger based on an abnormal laboratory value. A total of 364 alerts were generated for 107 patients; 154 (42.3%) alerts were accepted.

Conclusions

We proposed an ontology-based approach to provide support for improving medication appropriateness in older patients with multimorbidity in a scalable, sustainable, and reusable way. The chronic patient domain was built based on our previous research, reusing the existing framework. OntoPharma has been implemented in clinical practice and generates alerts, considering the following use cases: medication regimen complexity, anticholinergic and sedative drug burden, and the presence of triggers for identifying possible adverse events.
Adoption of Digital Learning Technology: An Empirical Analysis of the Determinants in Telecom Sector
Authors: Basit Abdul
Published: April 2023

Technology has advanced significantly from the analogue period to the digital era. Digital Learning Technology (DLT) is a learning paradigm based on the use of ubiquitous latest technologies, by using smart devices. It can be described as a learning environment that is assisted in daily life by wireless networks, mobile, and embedded computers. It aims to offer content and interaction to students wherever they are, at any time. The learning process has advanced thanks to the technology revolution, which has also fundamentally altered how knowledge is shared and learned. At present, there exist other frameworks too, but they are centered towards different paradigms, and point of view pertaining to DLT with its emphasis on Telecommunication Sector has not been taken into consideration. As, existing frameworks are centered towards different environments hence there exists a need to add dimensions of Empowered Learner, Digital Citizen, Knowledge Curator, Innovative Designer, Computational Thinker and Creator, Communicator & Global Collaborator. These have not been integrated together in existing available research. The study will ascertain level of knowledge of DLT and examined factors which affect the adoption rate, use, and role of DLT in telecoms setups. The results of this research will help create a framework that, if used in any academic or learning setting in a technology-based firm.
Prediction of Chronic Diseases from X-Rays Using Distributed Machine Learning
Authors: Kolhe Uddhav , Janaskar Omkar , Sonavne Diksha , Dubale Yash , Wagh Dr. Kavita
Published: April 2023

Abstract: There are various types of disease prediction models available in the market which predicts major chronic diseases but drawback is that each disease has a separate model which predicts and provides output to the user, there is no such model which will include multiple models into a single platform, for example heart disease has a separate model for prediction, covid-19 has a separate model which will provide result using machine learning algorithms, This article will briefly describe those drawbacks and will provide a proposed system for those issues.
Detection and Classification of Cyberbullying Using CR*
Authors: R Gayathri , D Lydia Beryl , M Gowtham , N Naveen Kumar , Anbarasi Dr. M. S.
Published: April 2023

Abstract: Cyberbullying is one of the latest threats in the online world, affecting millions of people worldwide. The detection of cyberbullying became a challenging task due to the complexity involved. In this paper, we propose a novel approach for cyberbullying detection using CR* which concatenates the deep learning model’s features such as Convolutional Neural Network (CNN) and Recurrent Neural Network (RNN) which helps in detecting text, audio, and emoji. Initially, we collect a dataset of cyberbullying messages from social media platforms. Then we integrate convolutional neural networks and recurrent neural networks to build our deep learning model entitled Convolutional Recurrent (CR*) to extract features from a combination of the text data, emoji, and audio. The multimodal features were then concatenated and passed through fully connected layers for classification. The proposed approach can be useful for detecting cyberbullying on various online platforms and can help prevent the spread of cyberbullying.
The Dual Mediating Effect of Children's Self-Esteem and Peer Attachment in the Effect of Mother's Positive Parenting Behavior on Children's Sense of Community: Focused on Gender Differences
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Hyo-Eun
Published: April 2023

Objectives This study was conducted to find out the differences between genders in the path of dual mediating children's self-esteem and peer attachment in the effects of mothers' positive parenting behavior on children's sense of community. Methods The subjects of this study were the 11th-year data of the Korean Children's Panel provided by the Research Institute for Parenting Policy. The subjects were 615 boys and 591 girls, and their mothers. Data were collected using the SPSS 26.0 Program and PROCESS macro 3.5, and the dual mediating effect was analyzed by applying model 6. The results of examining the correlation between children's sense of community. Results mothers' positive parenting behavior, children's self-esteem, and peer attachment are as follows. First, there was a positive correlation between each variable. Second, the more positive parenting behavior the mother showed in both girls and boys, the higher the child's self-esteem, and the higher the sense of community in children with high self-esteem. Third, it was confirmed that the mediating relationship of peer attachment in the relationship between the mother's positive parenting behavior and the child's sense of community differs according to gender. For girls, the mediating effect of peer attachment was not significant, but for boys, the mother's positive parenting behavior led to the formation of a child's community consciousness through peer attachment. Fourth, in both girls and boys, self-esteem and peer attachment were found to dual mediate the relationship between mothers' positive parenting behavior and children's sense of community. Furthermore, it was confirmed that boys are fully mediated by the dual mediation of self-esteem and peer attachment. Conclusions The results of this study suggest that the dual mediating effects of self-esteem and peer attachment show different pathways according to gender in the effects of positive parenting behaviors of mothers on children's sense of community.
ENTRE O “AGRO POP” E A AGRICULTURA FAMILIAR: UM BREVE RETRATO DO CENÁRIO AGROALIMENTAR BRASILEIRO
Authors: Lopes Marcio Caetano de Azevedo , Costella Irineu , Signor Altevir , Feiden Armin , Ahlert Alvori
Published: April 2023

O cenário agroalimentar brasileiro carrega uma complexidade de elementos que precisam ser observados de forma conexa, considerando, sobretudo, o contexto alimentar, socioeconômico e ambiental que tem distanciado o Brasil de um projeto inclinado ao desenvolvimento sustentável ou tornado o país inapto a guiar políticas públicas que transformem sistemas agroalimentares convencionais em sustentáveis. O objetivo deste artigo é abordar o contexto agroalimentar brasileiro e apontar o potencial da agricultura familiar para a superação dos desafios climáticos, sociais e alimentares. O artigo foi desenvolvido com base em dois Censos Agropecuários (2006 e 2017) - obtidos a partir do Sistema IBGE de Recuperação Automática (Sidra) -, em relatórios da Companhia Nacional de Abastecimento (CONAB) e com base em revisão de literatura acerca do tema. Conclui-se que apesar de a agricultura industrial carregar o peso do PIB brasileiro, estudos têm demonstrado que esse sucesso, necessariamente, não tem alavancado indicadores sociais nos municípios produtores de soja, por exemplo, ou mesmo não tem solucionado o problema da fome. Ademais, muitos outros dados apresentam os efeitos nocivos dos modelos convencionais de produção no clima. Este estudo aponta para um conjunto de dados e discussões a partir de uma análise crítica da realidade e lança indicativos sobre a necessidade de uma mudança de pensamento e na construção de políticas públicas que viabilizem e reforcem o protagonismo da agricultura familiar nos territórios a fim de atender às demandas ambientais, sociais e alimentares da sociedade contemporânea e futura.
Caracterización del suero bovino fetal proveniente de la industria cárnica mexicana en el cultivo celular
Authors: Preciado-Gutiérrez Francisco Javier , Masuoka-Ito David , Barrera-Bernal José Luis , Martín del Campo-Téllez Bryan Ivan , Esparza-Villalpando Vicente , Ramírez-Orozco Ricardo Ernesto
Published: April 2023

The present work aims to characterize a fetal bovine serum (FBS) obtained from the meat industry for use in cell culture. FBS is the most widely used supplement for cell culture since its complex composition provides the necessary nutrients for the growth of most cells. It is a by-product of the meat industry, and its availability and production depend mainly on two uncontrollable external factors, climatic conditions and changes in beef consumption. According to the strict quality features of the International Serum Industry Association (ISIA), tests for total proteins, osmolarity, presence or absence of pathogenic biological agents, pH, DNA concentration, biological contaminants, negative results, and cell viability were performed. The characterization of the serum in the DNA and total protein concentration tests showed significant differences. Additionally, osmolarity and pH did not present significant differences between groups. Regarding the viability test, no complication for cell growth was observed despite the differences found in the characterization. The results showed that the serum obtained from the meat industry could maintain cell cultures and allow cell proliferation compared to commercial serum. Furthermore, if FBS is not available, some kinds of plasma can be used as a surrogate to maintain cell cultures.
Dispute Occurrences During Construction Stages of Building Project: A Systematic Literature Review
Authors: Muhammuddin Muhammuddin , N N. , Danuri MS Mohd , Hanid Hanid , Mahanim Mahanim
Published: April 2023

Disputes arise during construction phases have a negative impact on the outcomes of projects. It is widely known from earlier studies that dispute is one of the factors contributing to the abandonment of building projects in Malaysia. Thus, there is a need to investigate the root causes of it because it leads to delay which affects the overall project performance and loss of money. The study on this research domain in Malaysian construction projects has only been conducted in the general context of the construction industry, without specializing in any specific type of projects or focusing on the phases of project. Hence, this paper aims to investigates the occurrences of dispute throughout the entire process of building construction project based on the traditional approach of project procurement, i.e., starting from the initiation stage until the defect liability period. This study was using systematic literature review and was conducted through searches of relevant publications from multiple electronic sources to review information using specific criteria. The results were presented in two major themes to serve as a theoretical base for the development of framework to minimise occurrence of construction dispute in building projects.
Impact of Traditional Procurement System on Construction Project Delivery
Authors: A. Okereke Reuben , Ihekweme Nneka Mercyjane , Adegboyega Mr.
Published: April 2023

Poor project performance issues have been a problem in the construction industry. A large number of projects have failed to meet their goal as a result of the choice of procurement adopted. The traditional method is the commonly used procurement method in the construction industries of the world, and its sequential and linear nature has serious implications on project time, cost and quality baseline performance. The purpose of this study was to determine the impact of the traditional procurement system on construction project delivery. The specific objectives of this study were; to assess the influence of the traditional procurement system on construction project parameters, and to determine the factors responsible for the poor bottom lines of traditionally procure construction projects. This study was achieved using a structured questionnaire administered to construction experts using a purposive sampling method. With a reliability index of over 0.800, the data gathered were analysed using appropriate descriptive tools. It was found that projects delivered through the traditional procurement system have the greatest impact on project time parameters, more on cost and quality parameters. Also, poor time, cost and quality performance are caused by major factors such as rework, poor original planning/unrealistic scheduling, poor communication among project participants, lack of competent staff and inadequate proper training of available staff, and design and documentation issues. Project clients and consultants should be careful in project procurement selection to ensure that maximum value and goals are met
K.D. Balmont as a Translator of The Ballad of Reading Gaol by Oscar Wilde
Authors:   Educational Center Ave lingva, Ivanova Alexandra S.
Published: April 2023

If we compare “The Ballad of Reading Gaol” and Balmont’s translation, we can conclude that the translation is adequate to the original in the majority of cases. A poetic license is allowed in eleven lines, in general the ballad contains one hundred and nine. Basically, when the poet translated the work, he saved the most of the characteristics of the literary structure. There were the repetitions and color epithets. It was important to show the philosophical idea of Wilde’s ballad. The 25 lines of the poem contain a difficult philosophical context, but only three stanzas were translated by Balmont with significant semantic changes. The main thing of these changes is to emphasize a universal meaning of the original. Oscar Wilde recognized his personal tragedy and he shared it with other suffering people, all of the prisoners of the Reading Gaol. Balmont directly addressed the philosophical meaning of the text, giving it a parable sound. Finally, the article presents examples showing that Balmont’s method of the translation is multi-faceted and also surpasses the translation of V. Bryusov in a number of ways.
Oscar Wilde and Marsel Proust: from Auditory Imagination to Synaesthesia
Authors:   Lomonosov Moscow State University, Belavina Ekaterina M.
Published: April 2023

Music and hearing played an important role in the lives of Oscar Wilde (1854–1900) and Marcel Proust (1871–1922), both writers were particularly sensitive to human speech, the sound of the voice. Their one meeting in Paris was not the start of a friendship or a correspondence, but it did not go unnoticed: Oscar Wilde became one of the prototypes of Baron Charlus in the novel “A la Recherche du temps perdu”. Both Wilde and Proust admired John Ruskin, especially his voice. Both begin by publishing poems in which the work of the auditory imagination is most prominent. The evolution of the auditory imagination of both authors is examined in this article in terms of image-building strategies that engage different channels of perception, particularly the auditory. The mechanisms of language continue to operate in the auditory imagination, and it is here that the rhythmic and the acoustic (physiological) come into contact with semantics. Oscar Wilde’s prose is characterised by a combination of images of different perceptual modalities (auditory, visual, kinaesthetic). This transcoding allows you to structure impressions and capture a wider audience of readers, regardless of their prevailing modality of perception. In Marcel Proust’s novel, synesthesia, construction of images that include two or more different modalities, has become a hallmark of his writing style, whose distinctive elements are extended metaphor and metonymy.
Patient-related factors drive high rates of reported antibiotic allergies: a qualitative study
Authors: Berry Renee , Herrmann Susan , Lucas Michaela
Published: April 2023

Background Unnecessary antibiotic avoidance due to allergy
fears has adverse cost and health implications however, the problem is
difficult to resolve because patient and provider-related factors
leading to avoidance are multifactorial. The perspectives of patients
can be explored using qualitative research methods to reach the heart of
the problem. Objective To reveal factors leading patients to
report antibiotic allergy, and determine what education is required to
prevent the cycle of erroneous allergy reporting. Methods The
29 patients were a sample of convenience recruited from a tertiary
public hospital in Western Australia; 18 were inpatients and 11
outpatients, with a median age of 64.2 years, and 15 (55%) were female.
Semi-structured interviews assessed patients’ understanding and
knowledge of three topics: (1) antibiotic allergy, (2) antibiotic
allergy testing, and (3) outcomes of testing. Interview transcripts
underwent thematic analysis by two researchers, independently.
Results Three overlapping themes emerged as influential across
topics: (1) Severity of the Index Reaction, (2) Trust in family and
health care providers, and (3) Health literacy. Patients were largely
unaware of the benefits of confirmatory testing, and the detrimental
health consequences of unnecessary avoidance. Patients displayed trust
in health care providers’ expertise, and assumed that medical records
were accurate to prevent prescribing errors. Conclusions The
findings provide evidence for an effective patient education strategy,
and highlight failures among hospital and primary health providers to
recognise the potential harm of unverified antibiotic allergy.
Healthcare professionals are influential at multiple steps of a
patient’s healthcare journey and addressing unconfirmed antibiotic
allergy should be taken at each opportunity.
Conservation genomics of an endangered montane amphibian reveals low population structure, low genomic diversity, and selection pressure from disease
Authors: Trumbo Daryl , Hardy Bennett , Crockett Harry , Muths Erin , Forester Brenna , Cheek Rebecca , Zimmerman Shawna , Corey-Rivas Sarah , Bailey Larissa , Funk W. Chris
Published: April 2023

Wildlife diseases are a major global threat to biodiversity. Boreal
toads (Anaxyrus [Bufo] boreas) are a state-endangered species in the
southern Rocky Mountains of Colorado and New Mexico, and a species of
concern in Wyoming, largely due to lethal skin infections caused by the
amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd). We
performed conservation and landscape genomic analyses using single
nucleotide polymorphisms from double-digest, restriction site-associated
DNA sequencing in combination with the development of the first boreal
toad (and first North American toad) reference genome to investigate
population structure, genomic diversity, landscape connectivity, and
adaptive divergence. Genomic diversity (π=0.00034–0.00040) and
effective population sizes (Ne=8.9 –38.4) were low, likely due to
post-Pleistocene founder effects and Bd-related population crashes over
the last three decades, respectively. Population structure was also low,
likely due to formerly-high connectivity among a higher density of
geographically-proximate populations. Boreal toad gene flow was
facilitated by low precipitation, cold minimum temperatures, less tree
canopy cover, low heat load, and less urbanization. We also found
>8X more putatively-adaptive loci related to Bd intensity
than to all other environmental factors combined, as well as evidence
for genes under selection related to immune response, heart development
and regulation, and skin function. These data suggest boreal toads in
habitats with Bd have experienced stronger selection pressure from
disease than from other, broad-scale environmental variation. These
findings can now be used by managers to conserve and recover the species
through actions such as reintroduction and supplementation of
populations that have declined due to Bd.
Urban habitat fragmentation and floral resources shape the occurrence of gut parasites in two bumblebee species
Authors: Tommasi Nicola , Colombo Beatrice , Pioltelli Emiliano , BIELLA PAOLO , Casiraghi Maurizio , Galimberti Andrea
Published: April 2023

Urbanization and the expansion of human activities foster radical
ecosystem changes with cascading effects also involving host-pathogen
interactions. Urban pollinator insects face several stressors related to
landscape and local scale features such as green habitat loss,
fragmentation, and availability reduction of floral resources with
unpredictable effects on parasite transmission. Furthermore, beekeeping
may contribute to the spread of parasites to wild pollinators by
increasing the number of parasite hosts. Here we used DNA-based
diagnostics tools to evaluate how the occurrence of parasites, namely
microsporidians (Nosema spp.), trypanosomatids (Crithidia spp.) and
neogregarines (Apicystis bombi), is shaped by the above-mentioned
stressors in two bumblebee species (i.e, Bombus terrestris and B.
pascuorum). Infection rates of the two species were different and
generally higher in B. terrestris. Moreover, they showed different
responses towards the same ecological variables, possibly due to
differences in body size and foraging habits supposed to affect their
susceptibility to parasite infection. The probability of infection was
found to be reduced in B. pascuorum by green habitat fragmentation,
while increased along with floral resource availability. Unexpectedly,
B. terrestris had a lower parasite richness nearby apiaries probably
because parasites are prone to be transmitted among the most abundant
species. Our finding supports the need to design proper conservation
measures based on species-specific knowledge, as suggested by the
variation in the parasite occurrence of the two species. Moreover,
conservation policies aiming at safeguarding pollinators through flower
planting should consider the indirect effects of these measures for
parasite transmission together with pollinator biodiversity issues.
Analysis of Prescribing Patterns and Adverse Drugs Reactions in Diabetic Patients at Tertiary Care Hospital, Lucknow
Authors: SHADAB USMANI HUMAIRA , Khan Mohd. Muazzam , Ahmad Usama , Aagrahari Vikas , Ali Wajid , Ali Zakir , AJMAL MOHD , SHAMS ABU RAIHAN
Published: April 2023

Objective: To study the prescribing pattern and adverse drug reactions
(ADRs) of anti-diabetic drugs in a tertiary care hospital in Lucknow,
India. Methods: A prospective study was conducted over a period of 6
months at the inpatient and outpatient departments of the hospital. A
total of 100 patients with diabetes were included in our study.
Demographic characteristics were recorded and 100 prescriptions were
analyzed. ADRs were reported and analyzed. Results: Among the 100
patients, 58 were male and 42 were female. The majority of the patients
were in the age group of 41-60 years. Biguanides (38%) and
sulphonylureas (31%) were the most commonly prescribed anti-diabetic
drugs. A total of 8 ADRs were reported, including hypoglycemia, gastric
irritation, and abdominal discomfort. Metformin had the highest number
of ADRs among the oral hypoglycemic drugs. Conclusion: The study showed
that the prescribing pattern of anti-diabetic drugs in the hospital was
in line with the essential medicine list. ADRs were reported, with
hypoglycemia being the most common ADR observed. Continuous monitoring
and reporting of ADRs is necessary for the safe and effective use of
anti-diabetic drugs. Keywords: Prescribing pattern, adverse drug
reactions, anti-diabetic drugs, diabetes, metformin