bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on Suburban Land Use Optimization from the Perspective of Flood Mitigation—A Case Study of Pujiang Country Park in Shanghai
Authors: Xu Hui , Gao Junlong , Yu Xinchun , Wang Chunyang , Liu Yi , Wen Jiahong , Qin Qianqian
Published: April 2024

The integration of nature-based solutions into land use optimization has become a central focus of current research, primarily due to its effectiveness in mitigating flooding impacts and promoting sustainable development in both urban and rural areas. Taking Shanghai’s Pujiang Country Park as a case study, this paper conducts a simulation analysis to assess the flood mitigation effectiveness of three distinct land use patterns (Natural scenario, Scenario N; Complete urbanization scenario, Scenario U; Country Park Planning scenario, Scenario P) under five stormwater scenarios with return periods of 2, 5, 10, 20, and 50 years. The findings reveal that Scenario P exhibits superior flood mitigation performance, particularly under stormwater scenarios with a return period of less than 50 years. Building upon these results, the paper proposes recommendations for optimizing land use to mitigate the impact of flooding. This study is crucial for understanding the mechanisms involved in urban stormwater logging mitigation through land use methods and holds significance for decision-making in land use and planning at the micro level.
Directed Path 3-Arc-Connectivity of Cartesian Product Digraphs
Authors: Wei Xiaosha
Published: April 2024

Let D=(V(D),A(D)) be a digraph of order n and let r∈S⊆V(D) with 2≤|S|≤n. A directed (S,r)-Steiner path (or an (S,r)-path for short) is a directed path P beginning at r such that S⊆V(P). Arc-disjoint between two (S,r)-paths is characterized by the absence of common arcs. Let λS,rp(D) be the maximum number of arc-disjoint (S,r)-paths in D. The directed path k-arc-connectivity of D is defined as λkp(D)=min{λS,rp(D)∣S⊆V(D),S=k,r∈S}. In this paper, we shall investigate the directed path 3-arc-connectivity of Cartesian product λ3p(G□H) and prove that if G and H are two digraphs such that δ0(G)≥4, δ0(H)≥4, and κ(G)≥2, κ(H)≥2, then λ3p(G□H)≥min2κ(G),2κ(H); moreover, this bound is sharp. We also obtain exact values for λ3p(G□H) for some digraph classes G and H, and most of these digraphs are symmetric.
SARS-CoV-2 Omicron BA.1 Variant Infection of Human Colon Epithelial Cells
Authors: Antia Avan , Alvarado David M. , Zeng Qiru , Casorla-Perez Luis A. , Davis Deanna L. , Sonnek Naomi M. , Ciorba Matthew A. , Ding Siyuan
Published: April 2024

The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022. Studies indicate that Omicron replicates less efficiently in lung tissue compared to the ancestral strain. However, the infectivity of Omicron in the gastrointestinal tract is not fully defined, despite the fact that 70% of COVID-19 patients experience digestive disease symptoms. Here, using primary human colonoids, we found that, regardless of individual variability, Omicron infects colon cells similarly or less effectively than the ancestral strain or the Delta variant. The variant induced limited type III interferon expression and showed no significant impact on epithelial integrity. Further experiments revealed inefficient cell-to-cell spread and spike protein cleavage in the Omicron spike protein, possibly contributing to its lower infectious particle levels. The findings highlight the variant-specific replication differences in human colonoids, providing insights into the enteric tropism of Omicron and its relevance to long COVID symptoms.
U-CAN-seq: A Universal Competition Assay by Nanopore Sequencing
Authors: Diaz Jennifer , Sears John , Chang Che-Kang , Burdick Jane , Law Isabella , Sanders Wes , Linnertz Colton , Sylvester Paul , Moorman Nathaniel , Ferris Martin T. , Heise Mark T.
Published: April 2024

RNA viruses quickly evolve subtle genotypic changes that can have major impacts on viral fitness and host range, with potential consequences for human health. It is therefore important to understand the evolutionary fitness of novel viral variants relative to well-studied genotypes of epidemic viruses. Competition assays are an effective and rigorous system with which to assess the relative fitness of viral genotypes. However, it is challenging to quickly and cheaply distinguish and quantify fitness differences between very similar viral genotypes. Here, we describe a protocol for using reverse transcription PCR in combination with commercial nanopore sequencing services to perform competition assays on untagged RNA viruses. Our assay, called the Universal Competition Assay by Nanopore Sequencing (U-CAN-seq), is relatively cheap and highly sensitive. We used a well-studied N24A mutation in the chikungunya virus (CHIKV) nsp3 gene to confirm that we could detect a competitive disadvantage using U-CAN-seq. We also used this approach to show that mutations to the CHIKV 5′ conserved sequence element that disrupt sequence but not structure did not affect the fitness of CHIKV. However, similar mutations to an adjacent CHIKV stem loop (SL3) did cause a fitness disadvantage compared to wild-type CHIKV, suggesting that structure-independent, primary sequence determinants in this loop play an important role in CHIKV biology. Our novel findings illustrate the utility of the U-CAN-seq competition assay.
Anti-Herpes Zoster Vaccination of Fragile Patients in Hospital Setting: A Nudge Intervention in Italy
Authors: De Caro Francesco , Malatesta Francesca , Pecoraro Nadia , Capunzo Mario , Carpinelli Luna , Caruccio Simona , Cersosimo Giuseppina , Costantino Maria , Giordano Claudio , Longanella Walter , Patella Vincenzo , Saggese Tozzi Arcangelo , Savarese Giulia , Sinopoli Pio , Vozzella Emilia Anna , Moccia Giuseppina
Published: April 2024

Background: A nudge intervention against Herpes Zoster, created and implemented in Italy, is presented in order to administer the Shingrix vaccine on a sample of frail patients, as required by the National Prevention Plan. Individual and contextual factors associated with vaccine adherence were investigated. Method: 300 frail adult subjects underwent a full vaccine cycle with recombinant-Shingrix vaccine (RZV vaccine). Hospital Presidia of the Salerno University Hospital Authority, a Hospital Presidium of the Salerno Local Health Authority, and the Public Health Laboratory of the University of Salerno (Campania) participated in the intervention. An ad hoc questionnaire was administered with the following scales: EQ-5D, PSS-10, MSPSS, and representations of HZ and its consequences. Results: Some variables, such as peer support, doctor–patient relationship, level of education, and perception of health, are important in vaccine adherence and information processing. The following factors emerged from the factor analysis: Trust in collective knowledge and collective responsibility (F1); beliefs about virus risk and vaccine function (F2); information about virus and symptomatology (F3); and vaccine distrust (F4). Factor 4 correlates negatively with social support indices (R = −0.363; p < 0.001). There is a significant relationship between factor 3 and satisfaction with national information campaigns (F = 3.376; gdl = 5; p-value = 0.006). Conclusions: Future vaccination campaigns should be built with the aim of personalizing information and developing contextualized strategies, starting from understanding the stakeholders involved, cultural contexts, and organizational settings.
Application of One-Dimensional Hydrodynamic Coupling Model in Complex River Channels: Taking the Yongding River as an Example
Authors: Lv Pingyu , Kong Lingling , Chuo Ruiyuan , Liu Haijiao , Cai Siyu , Zhao Mengqi
Published: April 2024

River conditions are complex and affected by human activities. Various hydraulic structures change the longitudinal slope and cross-sectional shape of the riverbed, which has a significant impact on the simulation of water-head evolution. With continuous population growth, the hydrological characteristics of the Yongding River Basin have undergone significant changes. Too little or too much water discharge may be insufficient to meet downstream ecological needs or lead to the wastage of water resources, respectively. It is necessary to consider whether the total flow in each key section can achieve the expected value under different discharge flows. Therefore, a reliable computer model is needed to simulate the evolution of the water head and changes in the water level and flow under different flow rates to achieve efficient water resource allocation. A one-dimensional hydrodynamic coupling model based on the Saint-Venant equations was established for the Yongding River Basin. Different coupling methods were employed to calibrate the coupling model parameters, using centralised water replenishment data for the autumn of 2022, and the simulation results were verified using centralised water replenishment data for the spring of 2023. The maximum error of the water-head arrival time between different river sections was 4 h, and the maximum error of the water-head arrival time from the Guanting Reservoir to each key cross-section was 6 h. The maximum flow error was less than 5 m3/s, and the changing trend of the flow over time was consistent with the measured data. The model effectively solved the problem of low accuracy of the water level and flow calculation results when using the traditional one-dimensional hydrodynamic model to simulate the flow movement of complex river channels in the Yongding River. The output results of the model include the time when the water head arrives at the key section, the change process of the water level and flow of each section, the change process of the water storage of lakes and gravel pits, and the change process of the total flow and water surface area of the key section. This paper reports data that support the development of an ecological water compensation scheme for the Yongding River.
Highly efficient nanocellulose adsorbents
Authors:   Institute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia, Suchilina E. M. , Botin A. S. ,   Institute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia
Published: April 2024

Adapting the use of nanocellulose as a sorbent is currently considered an extremely pressing problem, as synthetic analogues, although perform their functions well, are often toxic and incapable of biodegradation. In addition, the production of such synthetic sorbents is quite expensive. Therefore, today the production and modification of nanocellulose in order to increase their absorption capacity is especially important. Furthermore, a number of new applications of nanocellulose have been presented in nanocomposites, Pickering emulsions, wood adhesives, wastewater treatment, and emerging biomedical technologies. The problems and possibilities of new materials based on nanocellulose are being actively discussed. In the course of this work, a composite based on nanocrystalline cellulose from buckwheat, characterized by high sorption properties, environmental safety, and low cost of production, was obtained. Modification of cellulose was carried out with lactic acid. Nine groups of nanocrystalline cellulose samples with different acid soaking times were synthesized, and the optimal time required for the complete grafting of the acid into cellulose was determined. The specific surface area of the composite material was calculated using the Congo red dye adsorption method. It has been found that the specific surface area of the modified composite is not inferior to the specific surface area of many synthetic adsorbents, and even surpasses them in terms of environmental and economic indicators.
Major problems of primary substance production in world pharmacy industry
Authors:   Deportment of marketing, RUDN University, Arianpoor Mohmmad Homayon , Chernikov Sergey Yurievich ,   Deportment of marketing, RUDN University
Published: April 2024

It should be clarified that nowadays in the rapidly developing world a great number of different countries all over the world are aiming to work out high-tech strategies in the development of pharmaceuticals. The fact is that this industry today is actively and dynamically developing even in view of the significant economic growth of multifunctional pharmaceuticals. To substantiate the relevance of the study it will also be important to note that the pharmaceutical industry today is being characterized by the highly pragmatic and also life-sustaining healthcare system itself for the people. Certainly, it will be essential to specify that the pharmaceutical industry is now particularly important for science because its progress in this direction can help to develop the investment potential of any state, and further this factor can affect the economic component of the state. A very today promising direction represents a unique opportunity for development both in science itself and in the field under consideration — pharmaceuticals. Among other things, it is the steadily increasing demand for the products themselves in this area that has also created a high demand among investors. The organization of knowledge-intensive work to create new drugs requires very high costs. Also, in addition to a significant monetary equivalent, the labor of hundreds of specialists is required, while the period of passing through all stages, from scientific research work to the introduction of drugs, followed by numerous inspections, is counted in tens of years. In this regard, the most powerful, economically developed countries have a large pharmaceutical industry. In addition to all other factors, it will be important to note that the pharmaceutical industry also requires the presence of really valuable and worthy personnel. Naturally, specialists should perfectly understand the key issues in this area, know everything necessary to create the desired product. Most often, thousands of people work on such a development, who should definitely be professionals in their field. Just for all the above-mentioned reasons, it is the large pharmaceutical industry that the most powerful, economically developed countries should have today.
Pesquisa de saúde nos agentes de segurança do Estado do Amapá
Authors: Gama Luis Henrique Cirino , Silva Uriel Davi de Almeida e , Mauriz Marcos Felipe Costa , Freitas Tássio Luiz da Silva , Gama Rosilene Cirino
Published: April 2024

Pesquisa de saúde realizada nos agentes de segurança pública do Estado do Amapá (Polícia Civil; Polícia Militar; Corpo de Bombeiros Militar; Polícia Técnico-Científica e Policiais Penais) através de exames laboratoriais, caracterização sociodemográfica, estilo de vida e nível de estresse no trabalho. Seu objetivo foi conhecer o perfil de saúde, características sociodemográficas e antecedentes de saúde dos profissionais de segurança do Estado do Amapá. Enquanto método de pesquisa realizou-se delineamento de estudo observacional. O projeto é composto por 3 fases, sendo elas: medidas antropométricas, exames laboratoriais e aplicação do questionário de perfil saúde. Os dados foram disponibilizados para a publicação deste artigo. Todo o processo foi elaborado visando conhecer o perfil de saúde dos profissionais de segurança pública do Amapá e a mensuração da vulnerabilidade ao estresse no trabalho. Nos resultados obtidos dos profissionais avaliados, evidencia-se que mais de 75% dos participantes possuem Índice de Massa Corpórea (IMC) aumentado, mais de 97% dos participantes se consideram felizes sempre ou a maior parte do tempo, mas 447 servidores indicaram índices altos ou muito altos de estresse, mais de 75% dos participantes têm uma percepção de ter a saúde boa ou ótima. Conclui-se que na pesquisa, de uma maneira geral, os números apresentados nos exames e nos questionários aplicados não são alarmantes, mas necessitam de um olhar atencioso e preventivo, priorizando tratamentos direcionados à melhoria da qualidade de vida, hábitos de saúde e do ambiente laboral desses profissionais.
Remoção de compostos sulfurados e nitrogenados de combustíveis diesel utilizando ecat-R em uma coluna de adsorção de leito fixo
Authors: Oliveira Thamayne Valadares de , Vieira Rafael Bruno , Ponte Haroldo de Araújo , Ponte Maria Jose Jerônimo de Santana , Yamamoto Carlos Itsuo , Souza Selene Maria de Arruda Guelli Ulson de , Souza Antônio Augusto Ulson de
Published: April 2024

O objetivo deste trabalho é propor a reciclagem de catalisadores desativados ou de equilíbrio (ecat-R) em colunas de dessulfurização e desnitrogenação por adsorção em leito fixo. O ecat-R é um resíduo de unidades de craqueamento catalítico fluidizado (FCC) remediado por tratamento eletrocinético com ácido sulfúrico. A dessulfurização por adsorção e a desnitrogenação em colunas foram avaliadas utilizando diesel modelo e real. O diesel modelo contém enxofre (dibenzotiofeno), nitrogênio (quinolina e indol) e compostos aromáticos (naftaleno). A seletividade para os compostos estudados foi investigada analisando as curvas de ruptura do combustível diesel modelo. O estudo do mecanismo de adsorção mostrou que a seletividade de adsorção diminui na seguinte ordem: QUI> NAF> IND> DBT. A adsorção do DBT, em coluna de leito fixo utilizando o diesel modelo, foi parcialmente reversível. Houve competição pelos sítios ativos entre os compostos. O ecat-R mostrou boa seletividade para aromáticos e compostos nitrogenados. Os dados experimentais do diesel real foram aplicados aos modelos de Thomas e de Yoon & Nelson para prever a curva de ruptura. Estas soluções analíticas ofereceram boas aproximações dos parâmetros operacionais que são muito úteis no projeto de colunas de adsorção de leito fixo, como a capacidade de adsorção e o tempo necessário para 50% de retenção do adsorbato.
Sustainable Airport Management and Airline Marketing
Authors: Aydın Sevgi
Published: April 2024

The aviation sector comprises every industry that provides direct assistance to mechanical air transportation. The aviation industry includes a variety of institutions, such as military aviation companies, aircraft manufacturers, and various commercial establishments, all of which play important roles. The analysis of airline market shares was carried out within the realm of the aviation industry. Considering the ongoing trajectory of increasing airline market shares, it is crucial for firms to commit resources towards investing in this industry. Furthermore, a thorough evaluation of the existing literature revealed a dearth of research specifically focused on airline marketing. The primary objective of this research was to address the existing gap in the literature. Sustainable airport management and business, the airline industry, business-to-business analytics in the airline sector, customer satisfaction, and customer experience were some of the facets investigated in this study. In addition, the study seeks to provide a SWOT analysis of the airline marketing strategies employed by transportation corporations.
Neural model of the vehicle control system in a racing game. Part 2. Research experiments
Authors: Bolesta Arkadiusz , Tchórzewski Jerzy
Published: April 2024

This article, which is a continuation of the article under the same main title and subtitle: part 1 Design and its implementation, includes the obtained results of research experiments with the use of a designed and implemented racing game. It uses a neural model of the vehicle motion control system on the racetrack in the form of a Perceptron Artificial Neural Network (ANN). In designing the movement of vehicles on the racetrack, the following were used, inter alia, Godot Engine and MATLAB and Simulink programming environment. The numerical data (14 input quantities and two output quantities) for ANN training were prepared with the use of semi-automatic measurement of the race track control points. This article shows, among others, the results of 10 selected research experiments, testing and simulation, confirming the correct functioning of both the computer game and the model of the neural control system. As a result of simulation tests, it turned out that the longest lap of the track in the conducted experiments lasted 4 minutes and 55 seconds, and the shortest - 10.47 seconds. In five minutes, the highest number of laps was 34, while the lowest numbers of laps were 1 and 5. In the course of the experiments it was noticed that under the same conditions the ANN learning outcomes are sometimes different.
K-means is probabilistically poor
Authors: Kłopotek Mieczysław
Published: April 2024

Kleinberg introduced the concept of k-richness as a requirement for an algorithm to be a clustering algorithm. The most popular algorithm k means dos not fit this definition because of its probabilistic nature. Hence Ackerman et al. proposed the notion of probabilistic k-richness claiming without proof that k-means has this property. It is proven in this paper, by example, that the version of k-means with random initialization does not have the property probabilistic k-richness, just rebuking Ackeman's claim.
Artificial Neural Network based on mathematical models used in quantum computing
Authors: Ruciński Dariusz
Published: April 2024

The article is a proposition of a new approach to building a neural model based on the system of Day-Ahead Market operating at TGE S.A. The reason for the proposed method is an attempt to find a better model for the DAM system. The proposed methodology is based on using mathematical models used in quantum computing. All calculations performed on learning the Artificial Neuron Network are based on operations described in Hilbert space. The main idea of calculations is to replace the data from the decimal system into the quantum state in Hilbert space and perform learning operations for a neural model of the DAM system in a special manner which relay on the teaching model for each position of the quantum register for all data. The obtained results were compared to the “classical” neural model with the use of a comparative model.
The concept of twin digital models as support for production and service processes of technical facilities
Authors: Simiński Przemysław
Published: April 2024

The article presents the concept of using twin digital models as support for production and service processes of technical facilities. The implementation of the concept can be helpful in diagnostic processes and proactively diagnose the condition of technical objects in real time and report actions to ensure the continuity of processes. The concept assumes the creation of a digital model of a technicalobject for the purposes of improving the operation processes of the machine park (means of transport, means of production). A comprehensive and integrated solution will improve work efficiency and lower service costs.
Some Issues of Rational Antibiotic Therapy for Acute Sinusitis
Authors: Маймур А.В. , Сачек М.М. , Пацикалик М.В.
Published: April 2024

Цель. Оценить знания врачей общей практики по диагностике и антибактериальной терапии острых синуситов. Методы. Проведено анкетирование 200 врачей общей практики. Большинство врачей (88%) работали в городских поселениях. Результаты. Обязательные диагностические мероприятия при оказании медицинской помощи в амбулаторных условиях при остром синусите правильно указали 70,5% респондентов. Каждый третий указал и дополнительное обследование, которое необходимо проводить при наличии определенных показаний, что является избыточным. К первой линии системной антибактериальной терапии в амбулаторных условиях при остром синусите анкетируемые отнесли ингибиторозащищенный аминопенициллин – амоксициллин / клавулановая кислота (69,5%) и амоксициллин (40,0%), а врачи, работающие в сельских поселениях, защищенный амоксициллин выбрали в 83,3% случаев. Каждый десятый считает, что стартовать необходимо с антибиотиков, которые в соответствии с нормативными документами относятся к альтернативным. Заключение. Установлен недостаточный уровень знаний врачей общей практики о диагностике и антибактериальной терапии острого синусита. Требуется совершенствование программ повышения квалификации врачей общей практики с акцентом на рациональное применение антибиотиков, что может стать реальным инструментом в борьбе с антибиотикорезистентностью.

Purpose. To assess the knowledge of general practitioners and local therapists in the diagnosis and antibacterial therapy of acute sinusitis. Research methods. A survey was conducted of 200 general practitioners. Most doctors (88%) worked in urban areas. Results: Mandatory diagnostic measures when providing medical care in an outpatient setting for acute sinusitis were correctly indicated by 70.5% of respondents. Every third person also indicated an additional examination that needs to be carried out if there are certain indications, which is redundant. The first line of systemic antibacterial therapy in an outpatient setting for acute sinusitis was considered to be inhibitor-protected aminopenicillin – amoxicillin/clavulanic acid (69.5%) and amoxicillin (40.0%), and doctors working in rural areas chose protected amoxicillin in 83.3% of cases. Every tenth person believes that it is necessary to start with antibiotics, which, in accordance with regulatory documents, are considered alternative. Conclusion. An insufficient level of knowledge of general practitioners about the diagnosis and antibacterial therapy of acute sinusitis has been established. It is necessary to improve training programs for general practitioners with an emphasis on the rational use of antibiotics, which can serve as a real tool in the fight against antibiotic resistance.
Cognitive Impairment without Dementia in Clinical Practice
Authors: Павловская Т.С. , Астапенко А.В.
Published: April 2024

Во всем мире наблюдается неуклонный рост количества пациентов с когнитивными нарушениями, что является значимой медико-социальной проблемой. Деменция представляет собой конечный этап сосудистых, дегенеративных и других заболеваний головного мозга, сопровождающихся когнитивным дефицитом. В настоящее время деменция является неизлечимым состоянием, поэтому особое внимание следует уделять недементным формам когнитивного снижения, своевременная диагностика которых расширяет потенциальные возможности терапевтического воздействия и в ряде случаев позволяет замедлить или приостановить прогрессирование когнитивного дефицита. В статье приведен обзор современных представлений о терминологии недементных когнитивных нарушений, их клинических особенностях, рассмотрены принципы классификации, подходы к диагностике, а также описаны основные аспекты ведения пациентов с данной патологией. В связи с низкой осведомленностью врачей различного профиля о самых ранних проявлениях когнитивного дефицита особое внимание уделено проблеме субъективных когнитивных нарушений.

There is a steady increase in the number of patients with cognitive impairments all over the world, which is a significant medical and social problem. Dementia is the final stage of vascular, degenerative and other brain diseases accompanied by cognitive deficits. Currently, dementia is an incurable condition, therefore, special attention should be paid to cognitive decline without dementia, the timely diagnosis of which expands the potential for therapeutic effects and, in some cases, allows you to slow down or suspend the progression of cognitive deficits. The article provides an overview of modern ideas about the terminology of cognitive impairment without dementia, their clinical features, discusses the principles of classification, approaches to diagnosis, and describes the main aspects of managing patients with this pathology. Due to the low awareness of doctors of various profiles about the earliest manifestations of cognitive deficits, special attention is paid to the problem of subjective cognitive decline.
Clinical and Pharmacological Characteristics of the Drug Modafinil
Authors: Кевра М.К. , Гавриленко Л.Н. , Попов А.С.
Published: April 2024

В Республике Беларусь зарегистрирована субстанция лекарственного вещества модафинил. До настоящего времени это первая субстанция данного вещества, произведенного на территории государств постсоветского пространства. Представлены результаты анализа литературных источников, и дана клинико-фармакологическая характеристика лекарственного вещества модафинил. Отражены данные клинических исследований использования модафинила, его эффектов, показаний, противопоказаний, а также результаты исследований воздействия модафинила на когнитивные функции, психическую работоспособность и способность повышать концентрацию внимания.

The substance of the medicinal substance modafinil is registered in the Republic of Belarus. To date, this is the first substance of this substance produced on the territory of the post-Soviet states. The results of the analysis of literary sources are presented and the clinical and pharmacological characteristics of the medicinal substance modafinil are given. The data of clinical studies of the use of modafinil, its effects, indications, contraindications, as well as the results of studies of the effects of modafinil on cognitive functions, mental performance and the ability to increase concentration are reflected.
Analysis of Industry 4.0 and the Building Inspection System in the Republic of Türkiye's Applications
Authors: Ak Cansu Nur , İlerisoy Zeynep Yeşim
Published: April 2024

Since the enactment of Law No. 4708 on Building Inspection, developments have taken place in the construction sector in Türkiye in terms of material production, their usage in construction sites, construction stages, project management, and implementation, which have led to the need for changes in the inspection field. In this study, the Building Inspection process was classified under seven headings within the scope of the Regulation. The fundamental problems in these headings were analyzed with research methods in the literature. Based on the information, which digital transformation technologies are included in the current practices and which ones are missing have been identified. Collaborations with which technology can solve existing problems have been interpreted, and solutions have been proposed to complete the shortcomings that may be experienced in the inspection field. It has been determined that Industry 4.0 Technologies should be adapted to every step of the inspection process for a healthy inspection system.
Effect of Explanation Videos on Learning: The Role of Attention and Academic Performance
Authors: Adler Melanie Victoria , Madsen Jens , Hedberg James , Steinberg Richard , Parra Lucas C.
Published: April 2024

Students often search for answers online, and gravitate to short explanation videos, which are abundant online. While they seem useful and can be quite engaging, it is unclear if these videos benefit classroom learning. We hypothesized that when carefully matched to the class instruction, video can be helpful, but that benefits will depend on the ability of students to pay attention. To test this we recruited students from The City College of New York from first- and second-year college physics classes (n=139) and showed them videos matching their course material. Quizzes before or after the videos measured the benefit of the video. We also measured eye movement to gauge attention and analyzed results as a function of grade point average (GPA). We saw a benefit of video on quiz performance for the average student, and larger effects for students with higher GPA. GPA was not correlated with attention, nor did attention consistently affect performance. In an online replication with participants of a broader STEM background (n=215) the benefit was apparent for only one of the four videos tested. We conclude that some short explanation videos available online can be an effective support to classroom instruction. However, they benefit mostly students that are strong academically, despite similar levels of overt attention across all students.
Hallazgos morfoanatómicos de tridactília en espécimen humanoide de Nasca-Perú
Authors: Hernández-Huaripaucar Hernández-Huaripaucar Edgar , Becerra-Canales Bladimir , Ybaseta-Medina Jorge
Published: April 2024

En la actualidad este hallazgo de trascendencia global, ha despertado el interés de científicos y académicos de diversos países del mundo, donde ya se han realizado estudios preliminares (2,5). El cuerpo encontrado, por sus rasgos anatómicos y estructurales a nivel de la pelvis correspondería a un espécimen femenino, denominada  la momia “María” y fue codificada como M001. Tiene una morfología general y un biotipo similar al humano y muestra entre otras características, rasgos morfológicos y anatómicos peculiares como la tridactília (presencia de tres dedos) en ambas manos y pies, los cuales al análisis radiológico y tomográfico evidencian una congruencia estructural, morfológica y anatómica, sin huellas de haber sido manipulados intencionalmente.
Al examen macroscópico y con magnificación en ambas manos se observa una morfología natural y rasgos cutáneos y topográficos uniformes, así como una transición uniforme y armonía volumétrica entre el ancho de la región del carpo y el ancho del metacarpo y de este con el ancho de los tres dedos de la mano. En el pie se evidencia similares características morfológicas, es decir una transición uniforme y armonía volumétrica entre el ancho de la región del tarso y el ancho del metatarso y de este con el ancho de los tres dedos del pie.
Análisis de las características clínico-epidemiológicas de adolescentes embarazadas, atendidas en un Hospital General de Ica, Perú
Authors: Ybaseta Medina Jorge , Meza León Jesús , Morales Bellido Elizabeth , Condori Orosco Mayli M. , Cornejo Chacaltana Rosa G.
Published: April 2024

Introducción: aproximadamente la décima parte de todos los nacimientos ocurren en mujeres adolescentes y más del 90% son en países en desarrollo. En Perú se describen factores sociodemográficos y sanitarios a nivel individual y territorial asociados al embarazo adolescente. El objetivo del estudio fue identificar la proporción y las características clínico-epidemiológicas de adolescentes embarazadas atendidas en el Hospital Santa María del Socorro. Métodos: estudio descriptivo, analítico, transversal y prospectivo. La muestra de tipo censal fue de 198 que cumplieron con los criterios de elegibilidad. Los criterios de inclusión correspondieron a toda adolescente embarazada que asistió a su control prenatal. Se aplicó un cuestionario con preguntas abiertas y cerradas. Análisis estadístico se realizó con el programa EPIINFO Versión 7.0.9.34 (CDC, Atlanta, EUA). Resultados: las gestantes adolescentes presentan una edad promedio de 17 años, e inicio de las relaciones sexuales a los 15 años, 84% tiene educación secundaria, el 64% procede del área rural y el 33.3% del distrito de Ica. El 57,6 utiliza métodos de planificación familiar. Discusión: las adolescentes de zonas rurales tienen más probabilidades de iniciar la maternidad que las adolescentes de zonas urbanas. Esto podría deberse a la falta de oportunidades educativas, la pobreza y el acceso limitado a los servicios de salud. Existe acceso a planificación familiar, sin embargo hay gestación por falla de método, probablemente por incumplimiento de indicaciones médicas. El estudio puede ayudar a los formuladores de políticas y a los funcionarios de salud a diseñar intervenciones para prevenir el embarazo en adolescentes. Palabras clave: adolescentes, proporción, características, embarazo en adolescencia, salud reproductiva, Perú.
Nuevos avances en el manejo de la mucopolisacaridosis: medicina traslacional como estrategia innovadora
Authors: Serna Trejos Juan Santiago , Perea Serna Maria Camila , Acosta Acosta Christian Francisco , Bermúdez Moyano Stefanya  Geraldine
Published: April 2024

Las enfermedades por acumulación derivan de errores innatos del metabolismo, que contribuyen en algunas condiciones a enfermedades coloquialmente denominadas “enfermedades de depósito” o por almacenamiento lisosomal, estas entidades representan cerca de 1 caso por cada 5000 nacidos vivos. La mucopolisacaridosis (MPS) cobra gran relevancia dentro de este tipo de enfermedades de depósito, sus manifestaciones clínicas están dadas por alteraciones en la degradación de los glucosaminoglicanos a raíz de la deficiencia de enzimas como la hidrolasas ácidas lisosomales (1).
Existen cerca de 11 hidroxilasas, cuyos espectros clínicos y genéticos pueden desencadenarse a raíz del déficit de cada una de estas, generando síndromes conocidos como el síndrome de Hurler, síndrome de Scheie, Síndrome de hunter, síndrome de San Filippo, síndrome de Morquio, síndrome de Maroteaux, síndrome de Sly, síndrome de Natowicz , entre otros (2).
Correlación imagenológica - patológica: “Crazy Paving”
Authors: Dávila-Hernández Carlos Alberto , Revatta Salas Marcos Ricardo , Franco Soto Mario Luis
Published: April 2024

Se trata de paciente varón, de 49 años de edad, que presenta dificultad respiratoria, y se manifiesta a pequeños esfuerzos, taquipneico, que le imposibilita el decúbito dorsal, ha recibido tratamiento particular con azitromicina 500 mg y salbutamol inhalador por 03 días, al no presentar mejoría, acude al hospital IV “Augusto Hernández Mendoza”, con antecedente de covid-19 en dos oportunidades en 2021 y 2022; en la tomografía axial computarizada sin contraste: se observa parénquima pulmonar con superposición del patrón en vidrio deslustrado y la presencia de engrosamientos septales interlobulillares e intralobulillares,compatible con patrón de: CRAZY PAVING.El patrón crazy paving es un hallazgo tomográfico inespecífico que consiste en la superposición del patrón en vidrio deslustrado con la presencia de engrosamientos septales interlobulillares e intralobulillares, que nos recuerdan a las calles medievales europeas; descritas por Murch y Carr en el año de 1989 (1).
construção do personagem judeu porto-alegrense em ˜"Diário da queda", de Michel Laub
Authors: Jovchelovitch Laura
Published: April 2024

Este artigo analisa a construção do personagem judeu porto-alegrense em Diário da queda, de Michel Laub (2011), tendo em vista os traços culturais que ele carrega e a importância do judaísmo e de Porto Alegre para a narrativa. Utilizando como principais referenciais teóricos os estudos de Luiz Antonio de Assis Brasil (2019) e James Wood (2017) sobre construção de personagem e, sobre identidade judaica, os de Moacyr Scliar (1985), Elizabeth Roudinesco (2010) e Amós Oz e Fania Oz-Salzberger (2015), o ensaio investiga o modo como o personagem se relaciona com as interações intergeracionais e com os traumas individual e coletivo. Também reflete sobre o papel da escrita dos homens de três gerações da família do personagem na transmissão do judaísmo.
Tessituras da identidade judaica na narrativa de Elisa Lispector
Authors: Silva Patrícia Lopes da
Published: April 2024

A análise da ficção de Elisa Lispector é um espaço para problematizar a condição das mulheres na sociedade, destacando seu testemunho enquanto escritora judia. O romance No Exílio (1948) a autora oferece uma significativa contribuição literária ao registrar a saga da família Lispector durante o exílio na Europa. Ao atravessar o continente, enfrentando perseguições de cossacos e inimigos judeus, a narrativa descreve as dificuldades enfrentadas pela comunidade judaica em busca do direito fundamental de viver. O estilo direto da obra, desprovido de desvios literários e recursos vocabulares excessivos, evidencia a luta dessa comunidade pela valorização desse direito essencial. A protagonista do romance, filha mais velha de uma família judia, explora, por meio da memória, o passado de agonia e aflição durante a jornada do país de origem para uma nova terra. Nesse sentido, o presento estudo tem o objetivo de analisar como a identidade judaica da autora aparece no livro no exílio, por meio da voz autoral. A identidade judaica, como abordada no romance e no contexto mais amplo, é entendida como uma interseção complexa entre elementos religiosos, culturais e históricos. Os preceitos judaicos, baseados na Torá, fornecem um arcabouço ético e espiritual, orientando a vida dos judeus em rituais de oração, celebrações festivas, práticas alimentares e normas éticas. Esses preceitos não apenas orientam a conduta individual, mas também fortalecem a coesão comunitária, transmitindo a identidade judaica ao longo das gerações. A observância das práticas religiosas, rituais familiares e a ligação profunda com a comunidade judaica global são meios essenciais de manutenção e transmissão dessa identidade rica e distintiva ao longo do tempo. Quanto aos aspectos metodológicos, será feita a análise textual do corpus escolhido, a partir da revisão bibliográfica. Para essa investigação, recorreremos à algumas reflexões críticas e teóricas de autores como Geertz (1989), Yerushalmi (1989), Amós Oz e Fania Oz-Salzberger(2015), dentre outros. Este estudo busca assim contribuir para uma compreensão mais aprofundada da literatura judaica e da identidade judaica na obra de Elisa Lispector.
Dynamic Image Optimization and Code Generation Platform for Enhanced Data Augmentation
Authors:   Department of Data Science and Business Systems, School of Computing, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai (Tamil Nadu), India., Saivijaay V K  , Kumar Dr. S. Ganesh ,   Department of Data Science and Business Systems, School of Computing, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai (Tamil Nadu), India.
Published: April 2024

In the rapidly evolving domain of machine learning, the critical role of data quality, particularly image data, cannot be overstated. This research introduces a novel system uniquely designed to significantly improve the preprocessing and augmentation of image data for machine learning applications. At its core, the platform emerges as a comprehensive solution, meticulously bridging the gap between the acquisition of raw image data and its transformation into an optimized form ready for machine learning algorithms. What has been discovered, is a multifaceted system that not only simplifies the enhancement of image data but also elevates the quality of machine learning models by providing access to advanced image optimization techniques. The system distinguishes itself through a highly intuitive user interface that guides users in selecting and applying a variety of optimization strategies. These strategies are meticulously designed to enhance image quality and diversity, which in turn, can significantly improve the performance of machine learning models trained with such data. The platform's backend, powered by Python and leveraging libraries such as OpenCV, Pillow, and scikit-image, coupled with a responsive front end, ensures a seamless user experience and high-quality image processing. The generation of Python code for each processed image is a distinctive feature that enhances the platform's educational value, allowing users to learn, customize, and integrate optimization techniques into their workflows. Moreover, the inclusion of an API extends the platform's utility beyond its web interface, facilitating the automation of data augmentation pipelines and integration with external applications. This platform not only meets the immediate needs of data scientists and machine learning practitioners for data preprocessing and augmentation but also contributes significantly to the field by promoting understanding and application of image optimization techniques.
Reviewing the Concepts of Productivity Management
Authors:   Department of Business Administration, Aligarh Muslim University, Aligarh (Uttar Pradesh), India., Idehlu Hassan Afkari , Ahmed Prof. Salma ,   Department of Business Administration, Aligarh Muslim University, Aligarh (Uttar Pradesh), India., Noori Mohammad Idris ,   Department of Business Administration, Aligarh Muslim University, Aligarh (Uttar Pradesh), India.
Published: April 2024

Experts and academics in disciplines including economics, industrial and organisational psychology, accounting, physics, engineering, and management have previously focused on productivity. They define and interpret productivity differently as a result of their varied understandings of knowledge, experience, fields, and environmental factors. Many factors are effective in the definition and views of different schools towards productivity, about that how organizations, Groups, Human beings, Machines work in different environments and how their productivity should be measured each, and discipline has its own principles and insights. Considering that the importance of management concepts is due to their role in the organization's productivity, managers should work on productivity both in the short term and in the long term to avoid the challenges caused by the lack of productivity growth. This research systematically examines the concept of productivity and identifies factors affecting it based on Joseph Prokopenko's model. The purpose of this article is to examine the different ways of dealing with the concepts of "productivity" in the literature and to show that the definitions used regarding productivity do not follow a common grammar. Due to a misunderstanding of the concepts of productivity and the factors affecting it, most measurement and improvement methods are used without a clear understanding of what should be measured or improved. Therefore, this study reviews the concepts of productivity, examines the main factors of productivity (efficiency and effectiveness) and explains the different relationships between input and output in productivity, and explains the factors affecting productivity based on Joseph Prokopenko's model.
PENGARUH KOMBINASI HIDROKSIPROPIL METIL SELULOSA DAN CARBOPOL® 940 TERHADAP SIFAT FISIK DAN STABILITAS ANTIOKSIDAN GEL SLEEPING MASK EKSTRAK KAYU SECANG
Authors: Al-Hakim Nur Achsan , Pratiwi Gladdis Kamilah , Alatas Fikri , Rahayu Novitri Sri
Published: April 2024

Perawatan kulit menjadi salah satu upaya dalam mencegah penuaan dini, diantaranya dengan memanfaatkan bahan alami sebagai sumber antioksidan. Kayu secang (Caesalpinia sappan L.) merupakan salah satu tumbuhan yang mengandung antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kombinasi bahan pembentuk gel hidroksipropil metil selulosa (HPMC) dan Carbopol® 940 pada formulasi gel sleeping mask ekstrak kayu secang terhadap sifat fisik dan stabilitas antioksidannya. Sediaan gel sleeping mask dibuat dengan lima variasi rasio HPMC dan Carbopol® 940, yaitu 5:0 (F1), 0:5 (F2), 2,5:2,5 (F3), 3:2 (F4), dan 3,5:1,5 (F5). Evaluasi fisik sediaan meliputi organoleptik, pengukuran pH dan viskositas, homogenitas, uji daya sebar, serta penentuan stabilitas fisik aktivitas antioksidan sediaan gel sleeping mask. Aktivitas antioksidan ditetapkan menggunakan metode 2,2-difenil-1-pikrilhidrazil (DPPH). Hasil evaluasi fisik sediaan gel sleeping mask menunjukkan bahwa F5 merupakan formula yang terbaik dan stabil selama penyimpanan 28 hari, dan memenuhi parameter ideal sediaan kosmetik topikal, serta memiliki aktivitas antioksidan yang stabil. Penelitian ini menunjukkan bahwa ekstrak kayu secang dapat diformulasikan menjadi sediaan gel sleeping mask dan dengan memodifikasi agen pengental dalam formulasi menghasilkan sediaan yang baik dan stabil, serta penelitian ini menjadi pertimbangan ilmiah sebagai terapi alternatif dalam upaya mencegah penuaan dini.

Kata kunci : antioksidan, Carbopol® 940, ekstrak kayu secang, HPMC, gel sleeping mask