bluuebunny/crossref_metadata_2025 huggingface dataset:
Sex-dependent variation in cartilage adaptation: from degeneration to regeneration
Authors: Patel Jhanvee , Chen Song , Katzmeyer Torey , Pei Yixuan Amy , Pei Ming
Published: April 2023

Despite acknowledgement in the scientific community of sex-based differences in cartilage biology, the implications for study design remain unclear, with many studies continuing to arbitrarily assign demographics. Clinically, it has been well-established that males and females differ in cartilage degeneration, and accumulating evidence points to the importance of sex differences in the field of cartilage repair. However, a comprehensive review of the mechanisms behind this trend and the influence of sex on cartilage regeneration has not yet been presented. This paper aims to summarize current findings regarding sex-dependent variation in knee anatomy, sex hormones’ effect on cartilage, and cartilaginous degeneration and regeneration, with a focus on stem cell therapies. Findings suggest that the stem cells themselves, as well as their surrounding microenvironment, contribute to sex-based differences. Accordingly, this paper underscores the contribution of both stem cell donor and recipient sex to sex-related differences in treatment efficacy. Cartilage regeneration is a field that needs more research to optimize strategies for better clinical results; taking sex into account could be a big factor in developing more effective and personalized treatments. The compilation of this information emphasizes the importance of investing further research in sex differences in cartilage biology.
Intelligent prediction of sudden cardiac death based on multi-domain feature fusion of heart rate variability signals
Authors: Yang Jianli , Sun Zhiqiang , Zhu Weiwei , Xiong Peng , Du Haiman , Liu Xiuling
Published: April 2023

Background and objective

Sudden cardiac death (SCD) is one of the leading causes of death in cardiovascular diseases. Monitoring the state of the heart in real time and giving early warning of possible dangers by using ambulate electrocardiogram signals are the keys to prevent cardiovascular death. However, due to the diversity inducing factors of SCD and great individual differences, accurate prediction of SCD using electrocardiogram is a hard task, especially applied in portable electrocardiograph.

Methods

This paper proposed a multi-domain features fusion algorithm to predict SCD. Heart rate variability (HRV) signals was used to investigate the characters of SCD. A multiscale variation feature extracted from multiscale poincare plots was proposed to demonstrate the dynamic changes of HRV along different scales. A time-domain feature, Shannon entropy and this multiscale variation feature were combined by using SVM classifier to classify SCD. HRV signals from different time periods prior to SCD onset were used to test the effectiveness of the SCD prediction algorithm. And the dynamic variation characteristics of SCD prediction accuracy for each minute were also studied.

Results

In the prediction of SCD using the 70-min HRV signals before the onset of SCD, the average prediction accuracy only using the multiscale variation feature reached to 85.83%, which verified the effectiveness and high specificity of this multiscale variation feature. By combining time domain, Shannon entropy and the multiscale variation feature, the average prediction accuracy was improved to 91.22%. Through fusing multi-domain feature extracted in this paper, the advance prediction time was increased to 70 min before the onset of SCD.

Conclusions

A feature with high sensitivity and specificity is proposed to predict SCD. By fusing multi-domain features of HRV signals, a high prediction accuracy is achieved and the advance prediction ability is improved. The algorithm is low computational complexity and easy to integrate into cardiovascular intelligent monitoring equipment, making the intelligent monitoring and real-time early warning of SCD becomes possible.
Some power allocation algorithms for cognitive uplink satellite systems
Authors: Louchart Arthur , Tohidi Ehsan , Ciblat Philippe , Gesbert David , Lagunas Eva , Poulliat Charly
Published: April 2023

Cognitive satellite communication (SatCom) is rapidly emerging as a promising technology to overcome the scarcity of the exclusive licensed band model in order to fulfill the increasing demand for high data rate services. The paper addresses power allocation methods for multi-operator multi-beam uplink satellite communication systems co-existing with a Ka-band terrestrial network, using cognitive radio paradigm. Such a scenario is especially challenging because of (i) the coexisting multiple SatCom operators over the cognitive band need to coordinate the use of their resources under limited inter-operator information exchange, and (ii) nonlinear onboard high power amplifier (HPA) which leads to nonlinear interference between users and beams. In order to tackle the first challenge, we propose distributed power allocation algorithms including the standard Alternate Direction Multiplier Method (ADMM); Regarding the HPA nonlinear impairment, we propose nonlinear-aware power allocation based on Signomial Programming. The proposed solutions outperform state-of-the-art in both cases.
Does contract farming affect technical efficiency? Evidence from soybean farmers in Northern Ghana
Authors: Selorm Ayeduvor , Sarpong D. B. S. , Egyir Irene S. , Mensah Bonsu Akwasi , An Henry
Published: April 2023

Understanding how and the extent to which contract farming arrangements impact agricultural productivity is important to ensuring that policies are designed to maximize the likelihood of success. Using cross-sectional data from 516 soybean farmers in Northern Ghana, we provide empirical evidence that contract farming increases soybean productivity and technical efficiency in Northern Ghana. We use propensity score matching to reduce bias from observables, and then estimate a stochastic production frontier model that addresses selection bias arising from unobservable variables. We find that the technical efficiency levels of contract farmers are 77 percent compared with 69 percent for non-contract farmers. We also find that access to credit, extension contact, and farmer group membership are key determinants of participating in contract farming.
Pectin modulates intestinal immunity in a pig model via regulating the gut microbiota-derived tryptophan metabolite-AhR-IL22 pathway
Authors: Dang Guoqi , Wen Xiaobin , Zhong Ruqing , Wu Weida , Tang Shanlong , Li Chong , Yi Bao , Chen Liang , Zhang Hongfu , Schroyen Martine
Published: April 2023

Background

Pectin is a heteropolysaccharide that acts as an intestinal immunomodulator, promoting intestinal development and regulating intestinal flora in the gut. However, the relevant mechanisms remain obscure. In this study, pigs were fed a corn-soybean meal-based diet supplemented with either 5% microcrystalline cellulose (MCC) or 5% pectin for 3 weeks, to investigate the metabolites and anti-inflammatory properties of the jejunum.

Result

The results showed that dietary pectin supplementation improved intestinal integrity (Claudin-1, Occludin) and inflammatory response [interleukin (IL)-10], and the expression of proinflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) was down-regulated in the jejunum. Moreover, pectin supplementation altered the jejunal microbiome and tryptophan-related metabolites in piglets. Pectin specifically increased the abundance of Lactococcus, Enterococcus, and the microbiota-derived metabolites (skatole (ST), 3-indoleacetic acid (IAA), 3-indolepropionic acid (IPA), 5-hydroxyindole-3-acetic acid (HIAA), and tryptamine (Tpm)), which activated the aryl hydrocarbon receptor (AhR) pathway. AhR activation modulates IL-22 and its downstream pathways. Correlation analysis revealed the potential relationship between metabolites and intestinal morphology, intestinal gene expression, and cytokine levels.

Conclusion

In conclusion, these results indicated that pectin inhibits the inflammatory response by enhancing the AhR-IL22-signal transducer and activator of transcription 3 signaling pathway, which is activated through tryptophan metabolites.
Progress towards dog-mediated rabies elimination in PR China: a scoping review
Authors: Shen Tianren , Welburn Susan Christina , Sun Long , Yang Guo-Jing
Published: April 2023

Background

Rabies continues to be a serious threat to global public health endangering people’s health and public health safety. In the People’s Republic of China, multi-sectoral and comprehensive prevention and control strategies have aimed to extensively curb human rabies transmission. Here, we examine the current state of rabies infection in China, explore strategic interventions put in place in response to WHO’s ambition of “Zero rabies deaths by 2030” and critically assess the constraints and feasibility of dog-mediated rabies elimination in China.

Methods

This study analyzed and evaluated the process towards dog-mediated rabies elimination in China from five perspectives: namely, human, dog, policy, challenge, and prospects. Evidence-based data on progress of dog-mediated rabies elimination in China was derived from a number of sources; a literature search was undertaken using PubMed, Web of Science and CNKI databases, distribution data for human rabies cases as derived from the Data-center of the China Public Health Science and policy and document data were obtained from official websites of the relevant China ministries and commissions.

Results

The incidence of human rabies cases in China have shown a downward trend year-on-year since 2007. Implementation of a government-led, multi-sectoral “One Health” approach to combating rabies has driven down the total number of rabies deaths nationwide to around 200 in 2020. The number of provincial-level administrative divisions (PLADs) reporting human cases of rabies has also decreased to 21 in 2020, 13 of which reported less than 10 cases. Furthermore, the number of outpatient visits seeking rabies post-exposure prophylaxis has risen dramatically over the past two decades, with demand being 15 times higher than it was initially. There remain however, significant gaps in rabies elimination outcomes across the different regions of China. To date the target of achieving a canine rabies vaccination rate of > 75% has not been met. The challenges of rabies immunization of dogs and dog management in underdeveloped cities and rural areas need to be addressed together with more effective animal surveillance and rabies risk from and too wildlife and livestock.

Conclusions

The Chinese government-led, multi-sectoral “One Health” approach to combating rabies and has made significant progress over the past decade. Development and adoption of more cost-effective One Health strategies can achieve more nationally beneficial rabies elimination outcomes. The ambitious target of “Zero rabies deaths by 2030” can be met through establishment of long-lasting herd immunity in dogs by means of dog mass vaccination campaigns, dog population management, epidemiological surveillance and the application of large-scale oral rabies vaccine to eliminate rabies in wild animals coupled with deployment of cost-effective human post-exposure prophylaxis, and community education.

Graphical Abstract
Collaborative care in eating disorders treatment: exploring the role of clinician distress, self-compassion, and compassion for others
Authors: Geller Josie , Fernandes Avarna , Kelly Allison C. , Samson Lindsay , Srikameswaran Suja
Published: April 2023

Background

Collaborative care is described as showing curiosity and concern for patient experiences, providing choices, and supporting patient autonomy. In contrast, in directive care, the clinician has authority and the patient is expected to adhere to a treatment plan over which they have limited influence. In the treatment of eating disorders, collaborative care has been shown to be more acceptable and produce better outcomes than directive care. Despite widespread patient and clinician preference for collaborative care, it is common for clinicians to be directive in practice, resulting in negative patient attitudes toward treatment and poor adherence. There is a need to understand factors which contribute to its use.

Purpose

This study examined the contribution of clinicians' experience of distress and how they relate to themselves and others in times of difficulty (self-compassion and compassion for others), to their use of collaborative support.

Method

Clinicians working with individuals with eating disorders from diverse professional backgrounds (N = 123) completed an online survey.

Results

Whereas clinician distress was not associated with use of collaborative or directive support behaviours, self-compassion and compassion for others were. Regression analyses indicated that compassion for others was the most important determinant of collaborative care.

Discussion

Relating to their own and others’ distress with compassion was most important in determining clinicians’ use of collaborative support. Understanding how to cultivate conditions that foster compassion in clinical environments could promote the delivery of collaborative care.
Medical instability in typical and atypical adolescent anorexia nervosa: a systematic review and meta-analysis
Authors: Brennan Cliona , Illingworth Sarah , Cini Erica , Bhakta Dee
Published: April 2023

This review investigates the relationship between weight and risk of medical instability (specifically bradycardia, hypotension, hypothermia, and hypophosphatemia) in adolescents with typical and atypical anorexia nervosa. Atypical anorexia nervosa, listed as an example under the DSM-5 category of Other Specified Feeding and Eating Disorders (OSFED), describes patients who are not clinically underweight but otherwise meet criteria for anorexia nervosa. There is a lack of empirical evidence exploring medical complications in adolescents presenting with atypical anorexia nervosa. The small number of studies that do exist in this area indicate that medical instability exists across a range of weights, with weight loss being associated with increased medical risk, independent of underweight. The aim of this review was to collate and analyse results from available studies and identify indicators of medical risk in these two groups of adolescents with restrictive eating disorders. Studies were identified by systematic electronic search of medical databases, including PubMed and EMBASE. All studies investigated the relationship between weight and medical instability and included adolescents diagnosed with anorexia nervosa or atypical anorexia nervosa. One randomised controlled trial, five cohort studies and three chart reviews were included, with a total sample size of 2331 participants. Between 29 and 42% of participants presented with medical instability requiring hospitalisation, in the absence of underweight. Underweight adolescents were significantly more likely to have lower blood pressures (p < 0.0001) and bradycardia was significantly associated with greater weight loss (p < 0.05). There were no statistically significant associations found between degree of underweight and heart rate, temperature, or rate of weight loss (p = 0.31, p = 0.46 and p = 0.16, respectively). Adolescents that were less than 70% median body mass index were significantly more likely to have hypophosphatemia (p < 0.05). The findings of this review support the hypothesis that medical instability can occur across a range of weights in adolescent eating disorders, with rapid weight loss being an important indicator of increasing medical risk. Results were limited by the small number of existing studies that contained data for statistical analysis. Rapid weight loss should be considered as an important indicator of medical instability in adolescents presenting with both typical and atypical anorexia nervosa.
Racial disparities in youth pretrial detention: a retrospective cohort study grounded in critical race theory
Authors: Wen Andy , Gubner Noah R. , Garrison Michelle M. , Walker Sarah Cusworth
Published: April 2023

Background and method

Pretrial detention makes up 75% of juvenile detention admissions and contributes to the disproportionate contact of minoritized youth in the juvenile carceral system. Given that prior evidence largely examines differences between Black and white youth, this study expands research on disproportionate contact in the pretrial detention setting to Hispanic/Latinx, Indigenous, and Asian youth. With a sample of over 44,000 juvenile cases in a northwest state, we used a generalized linear mixed model to estimate the effect of individual level characteristics while accounting for the random effect of differences at the county level. Additionally, we utilized Critical Race Theory (CRT) in formulating our theoretical model and predictions and apply CRT in our analysis and discussion of our results. In doing so we hope to build upon its application in public health discourse for naming and deconstructing processes that lead to unjust social and health stratification.

Results

After factoring in gender, age, crime severity, previous offenses, and variation between counties, our analyses show that Black, Hispanic/Latinx, and American Indian/Alaskan Native youth are more likely to experience pretrial detention than white youth. The likelihood of pretrial detention for Asian youth and for youth identified as “Other” or “Unknown” was not significantly different from white youth.

Conclusions

As the iatrogenic effects of detention are disproportionately imposed upon youth of color—particularly Black, Indigenous, and Hispanic/Latinx youth—the disparities present in our study reveal further evidence of institutional racism. In this way, we can see how this carceral process operates as a mechanism of racialized social stratification as put forth by CRT. Considering implications for policy or further research, persistent disparity highlights an enduring need for building or strengthening diversion programs and alternatives to the carceral system, with emphasis on those that are culturally responsive.
The association between probationers’ addiction levels and socioeconomic-psychological characteristics
Authors: Yucel Inci Derya , Yararbas Gorkem
Published: April 2023

Objective

The aim of this study is to evaluate probationers’ addiction levels and associated socioeconomic and psychological features in Izmir Probation Directorate.

Methods

This cross-sectional study was conducted in Izmir Probation Directorate between August 27, 2018 and November 27, 2018. The study’s dependent variable was adult probationers’ addiction level which was evaluated by the Addiction Profile Index-Clinical Version (API-C). The independent variables were individual factors, social environmental factors, API-C scale subdimensions and perceived social support. For paired comparisons, Student’s t test and ANOVA were used. Linear regression analysis was used for multiple comparisons. p < 0.05 was accepted as the limit of statistical significance.

Results

A total of 200 male probationers participated in the study (82.3%, n = 243). The participants’ average age was 29.9 ± 7.7. The participants’ average addiction score was 5.65 ± 2.33. According to the results of the regression analysis; education level (B = 1.438, 95% CI 0.936, 1.941, p < 0.001) working status at a job (B = 2.687, 95% CI 1.428, 3.945, p < 0.001) father’s education level (B=-1.117, 95% CI -1.473, -0.762, p < 0.001) and anger management problems (B = 0.750, 95%CI 0.517, 0.982, p < 0.001) were explanatory for addiction level. The model was 50.8% explanatory of addiction level (p < 0.05).

Conclusion

Probationers who grew up with only their mother, whose father had a low education level, who had higher levels of anger management problems and who were unemployed had higher levels of addiction. These results emphasize the need for social work in the rehabilitation processes of individuals. Treating the risk factors indicated by the study results as screening and follow-up parameters in the probation population can be useful in improving the success of the probation program.
New GEONET analysis strategy at GSI: daily coordinates of over 1300 GNSS CORS in Japan throughout the last quarter century
Authors: Takamatsu Naofumi , Muramatsu Hiroki , Abe Satoshi , Hatanaka Yuki , Furuya Tomoaki , Kakiage Yasuaki , Ohashi Kazuyuki , Kato Chiaki , Ohno Keitaro , Kawamoto Satoshi
Published: April 2023

The station coordinates derived from GNSS (Global Navigation Satellite System) with a conventional static method underpin the study of Earth and planetary science and surveying and mapping. For the continuous provision of high-quality coordinates, it is mandatory to cope with the increasing deviation from the global standard reference frame and the launch of modern GPS (Global Positioning System) satellites. To provide coordinates agreed with ITRF2014 (International Terrestrial Reference Frame 2014) at several millimeters for GEONET (GNSS Earth Observation Network System) in Japan, we developed a new analysis strategy named F5 and assessed the reprocessed station coordinates from 1996. The major updates in F5 can be summarized as incorporating global network processing and enhancements in troposphere modeling. As for the troposphere enhancements, a modern mapping function VMF1 (Vienna Mapping Functions 1) was employed and time intervals for troposphere estimates were shortened. Station coordinates in the global network showed a great agreement with ITRF2014 at several millimeters in the recent 20 years and comparable or slightly better performance with IGS (International GNSS Services) Analysis Centers. The RMS (root mean square) averaged over all GEONET stations indicated very high accuracy of 3.2 mm (horizontal) and 7.3 mm (vertical); the latter accounts for an improvement of roughly 10% from the previous strategy. Sensitivity tests about troposphere estimates revealed that the reduced RMS was completely due to the short time intervals, not the use of VMF1, which contributed to partly suppressing the spurious vertical annual deformation. These results confirm that F5 is sufficiently accurate for the requirements of individual applications and infer the capability of detecting smaller signals the previous strategy could not resolve.

Graphical Abstract
Functional tailoring of a PET hydrolytic enzyme expressed in Pichia pastoris
Authors: Li Xian , Shi Beilei , Huang Jian-Wen , Zeng Ziyin , Yang Yu , Zhang Lilan , Min Jian , Chen Chun-Chi , Guo Rey-Ting
Published: April 2023

Using enzymes to hydrolyze and recycle poly(ethylene terephthalate) (PET) is an attractive eco-friendly approach to manage the ever-increasing PET wastes, while one major challenge to realize the commercial application of enzyme-based PET degradation is to establish large-scale production methods to produce PET hydrolytic enzyme. To achieve this goal, we exploited the industrial strain Pichia pastoris to express a PET hydrolytic enzyme from Caldimonas taiwanensis termed CtPL-DM. In contrast to the protein expressed in Escherichia coli, CtPL-DM expressed in P. pastoris is inactive in PET degradation. Structural analysis indicates that a putative N-glycosylation site N181 could restrain the conformational change of a substrate-binding Trp and hamper the enzyme action. We thus constructed N181A to remove the N-glycosylation and found that the PET hydrolytic activity of this variant was restored. The performance of N181A was further enhanced via molecular engineering. These results are of valuable in terms of PET hydrolytic enzyme production in industrial strains in the future.

Graphical Abstract
Visual and patient-reported outcomes of a diffractive trifocal intraocular lens in highly myopic eyes: a prospective multicenter study
Authors: Meng Jiaqi , Fang Yanwen , Lian Jingcai , Chen Xu , Zhou Jing , He Wenwen , Zhang Keke , Yang Fan , Lu Yi , Zhu Xiangjia
Published: April 2023

Background

To investigate the visual and patient-reported outcomes of a diffractive trifocal intraocular lens (IOL) in highly myopic eyes.

Methods

Patients with planned cataract removal by phacoemulsification and implantation of a trifocal IOL (AT LISA tri 839MP) were enrolled in the prospective, multicenter cohort study. Patients were allocated into three groups according to their axial length (AL): control group, AL < 26 mm; high myopia group, AL 26–28 mm; extreme myopia group, AL ≥ 28 mm. At 3 months post-surgery, data for 456 eyes of 456 patients were collected, including visual acuity, defocus curve, contrast sensitivity (CS), visual quality, spectacle independence, and overall satisfaction.

Results

After surgery, the uncorrected distance visual acuity improved from 0.59 ± 0.41 to 0.06 ± 0.12 logMAR (P < 0.001). In all three groups, about 60% of eyes achieved uncorrected near and intermediate visual acuity of 0.10 logMAR or better, but significantly fewer eyes in the extreme myopia group achieved uncorrected distance visual acuity of 0.10 logMAR or better (P < 0.05). Defocus curves revealed that the visual acuity was significantly worse in the extreme myopia group than others at 0.00, − 0.50, and − 2.00 diopters (P < 0.05). CS did not differ between the control and high myopia groups but was significantly lower in the extreme myopia group at 3 cycles per degree. The extreme myopia group also had greater higher-order aberrations and coma, lower modulation transfer functions and VF-14 scores, more glare and halos, worse spectacle independence at far distance, and consequently lower patient satisfaction than others (all P < 0.05).

Conclusions

In eyes with a high degree of myopia (AL < 28 mm), trifocal IOLs have been shown to provide similar visual outcomes to those in non-myopic eyes. However, in extremely myopic eyes, acceptable results may be obtained with trifocal IOLs, but a reduced level of uncorrected distance vision is expected.
Platform governance and sociological participation
Authors: Lu Peng , Zhou Lvjun , Fan Xiaoguang
Published: April 2023

The positive and negative effects of the participation of digital platform companies in governance are a major issue of the times. Starting from the three subfields of internal governance, external governance, and co-governance, we construct an analytical framework for digital platform governance to understand the four-sided relationship among digital platform companies, the state, the market, and society. From the perspective of enterprise autonomy, we should view the effectiveness of platform company participation in social governance dialectically. The key of promoting good platform governance is to improve the external structural pressure from the state, promote the reform of the endogenous governance of enterprises, and build a sustainable architecture for co-governance. The mission of sociologists includes not only explanation but also intervention.
Association of maternal nationality with preterm birth and low birth weight rates: analysis of nationwide data in Japan from 2016 to 2020
Authors: Okui Tasuku , Sato Yoko , Morokuma Seiichi , Nakashima Naoki
Published: April 2023

Background

The rate of low birth weight or preterm birth is known to vary according to the birth place of mothers. However, in Japan, studies that investigated the association between maternal nationalities and adverse birth outcomes are few. In this study, we investigated the association between maternal nationalities and adverse birth outcomes.

Methods

We obtained live birth data from the Vital Statistics 2016–2020 of the Ministry of Health, Labour, and Welfare. We used data on maternal age, sex, parity, gestational age, birth weight, number of fetuses, household occupation, paternal nationality, and maternal nationality for each infant. We compared the rates of preterm birth and low birth weight at term among mothers whose nationalities were Japan, Korea, China, Philippines, Brazil, and other countries. Log binomial regression model was used to investigate the association between maternal nationality and the two birth outcomes using the other infants’ characteristics as covariates.

Results

In the analysis, data on 4,290,917 singleton births were used. Mothers from Japan, Korea, China, the Philippines, Brazil, and other nations had preterm birth rates of 4.61%, 4.16%, 3.97%, 7.43%, 7.69%, and 5.61%, respectively. The low birth weight rate among Japanese mothers was 5.36% and was the highest among the maternal nationalities. Regression analysis showed that the relative risk for preterm birth among Filipino, Brazilian, and mothers from other countries (1.520, 1.329, and 1.222, respectively) was statistically significantly higher compared with Japanese mothers. In contrast, the relative risk for Korean and Chinese mothers (0.870 and 0.899, respectively) was statistically significantly lower compared with Japanese mothers. Mothers from Korea, China, the Philippines, Brazil, and other nations had a relative risk for low birth weight that was statistically significantly lower than that of Japanese mothers (0.664, 0.447, 0.867, 0.692, and 0.887, respectively).

Conclusions

Support for mothers from the Philippines, Brazil, and other countries are necessary to prevent preterm birth. A future study is necessary to investigate the differences in characteristics among mothers of different nationalities in order to uncover the reason for the high risk for low birth weight among Japanese mothers.
Pulmonary metastases of a borderline ovarian tumor with multiple cystic formations: a case report
Authors: Hamada Rintaro , Tsukamoto Yo , Odaka Makoto , Yabe Mitsuo , Shigemori Rintaro , Akiba Tadashi , Toya Naoki , Ohtsuka Takashi
Published: April 2023

Background

Metastatic lung tumors rarely present with cystic formations. This is the first report of multiple cystic formations in pulmonary metastases from mucinous borderline ovarian tumors written in English.

Case presentation

A 41-year-old woman underwent left adnexectomy + partial omentectomy + para-aortic lymphadenectomy for a left ovarian tumor 4 years ago. The pathological finding was mucinous borderline ovarian tumor with a microinvasion. A chest computed tomography performed 3 years after surgery revealed multiple cystic lesions in both lungs. After 1-year follow-up, the cysts increased in size and wall thickness. Subsequently, she was referred to our department with multiple cystic lesions in both lungs. No laboratory findings indicated infectious diseases or autoimmune disorders that could cause cystic lesions in both lungs. Positron emission tomography showed slight accumulation in the cyst wall. Partial resection of the left lower lobe was performed to confirm the pathological diagnosis. The diagnosis was consistent with pulmonary metastases from a previous mucinous borderline ovarian tumor.

Conclusions

This is a rare case of lung metastases from a mucinous borderline ovarian tumor presenting with multiple lesions with cystic formation. Pulmonary cystic formations in patients with a borderline ovarian tumor should be considered as possible pulmonary metastases.
Primary leiomyosarcoma of the inferior vena cava in a pediatric case: a case report and literature review
Authors: Yoshizawa Kazuki , Ohno Yasunari , Kurata Takashi , Takagi Yuki , Kasai Tomoko , Takizawa Momoko , Soejima Yuji
Published: April 2023

Background

Leiomyosarcoma is classified as a soft tissue sarcoma. In adults, leiomyosarcoma is the most common malignancy affecting the vascular system; however, vascular leiomyosarcoma in children is extremely rare as most pediatric soft tissue tumors are rhabdomyosarcomas. The survival rate is very low, and incomplete resection is a poor prognostic factor. There is also a high rate of distant recurrence, with the lungs and liver being the most common sites of metastasis. There is no established effective chemotherapy, and complete surgical resection is the only potentially curative treatment for leiomyosarcoma.

Case presentation

A 15-year-old female patient with no significant medical history presented with severe upper abdominal pain and was admitted. Abdominal contrast-enhanced computed tomography and magnetic resonance imaging showed a large retroperitoneal tumor protruding into the lumen of the inferior vena cava behind the liver and multiple small nodules, and metastasis to the liver was suspected. The tumor was 6 × 4 × 5 cm in diameter, located just behind the hepatic hilar structures, and was suspected to infiltrate into the right portal vein. The tumor was diagnosed as a leiomyosarcoma through an open tumor biopsy. As the multiple liver metastases were located only in the right lobe of the liver on imaging, we performed tumor resection with right hepatectomy and replacement of the inferior vena cava (IVC). The postoperative course was uneventful; however, on postoperative day 51, distant metastatic recurrences were found in the remaining liver and right lung. The patient was immediately started on chemotherapy and trabectedin proved to be the most effective drug in the treatment regimen; however, severe side effects, such as hepatotoxicity, prevented timely administration, and the patient passed away 19 months after surgery.

Conclusions

IVC resection and reconstruction combined with right hepatectomy were able to be safely performed even in a pediatric case. To improve the prognosis of leiomyosarcoma with multiple metastases, an effective treatment strategy combining surgical treatment and chemotherapy, including molecularly targeted drugs, should be established as early as possible.
Land use modification causes slow, but predictable, change in soil microbial community composition and functional potential
Authors: Louisson Z. , Hermans S. M. , Buckley H. L. , Case B. S. , Taylor M. , Curran-Cournane F. , Lear G.
Published: April 2023

Background

Bacterial communities are critical to ecosystem functioning and sensitive to their surrounding physiochemical environment. However, the impact of land use change on microbial communities remains understudied. We used 16S rRNA gene amplicon sequencing and shotgun metagenomics to assess soil microbial communities' taxonomic and functional responses to land use change. We compared data from long-term grassland, exotic forest and horticulture reference sites to data from sites that transitioned from (i) Grassland to exotic forest or horticulture and from (ii) Exotic forest to grassland.

Results

Community taxonomic and functional profiles of the transitional sites significantly differed from those within reference sites representing both their historic and current land uses (P < 0.001). The bacterial communities in sites that transitioned more recently were compositionally more similar to those representing their historic land uses. In contrast, the composition of communities from sites exposed to older conversion events had shifted towards the compositions at reference sites representing their current land use.

Conclusions

Our study indicates that microbial communities respond in a somewhat predictable way after a land use conversion event by shifting from communities reflecting their former land use towards those reflecting their current land use. Our findings help us to better understand the legacy effects of land use change on soil microbial communities and implications for their role in soil health and ecosystem functioning. Understanding the responsiveness of microbial communities to environmental disturbances will aid us in incorporating biotic variables into soil health monitoring techniques in the future.
Bacteria-based multiplex system eradicates recurrent infections with drug-resistant bacteria via photothermal killing and protective immunity elicitation
Authors: Xu Youcui , Wu Yi , Hu Yi , Xu Mengran , Liu Yanyan , Ding Yuting , Chen Jing , Huang Xiaowan , Wen Longping , Li Jiabin , Zhu Chen
Published: April 2023

Background

The high mortality associated with drug-resistant bacterial infections is an intractable clinical problem resulting from the low susceptibility of these bacteria to antibiotics and the high incidence of recurrent infections.

Methods

Herein, a photosynthetic bacteria-based multiplex system (Rp@Al) composed of natural
Rhodopseudomonas palustris
(Rp) and Food and Drug Administration-approved aluminum (Al) adjuvant, was developed to combat drug-resistant bacterial infections and prevent their recurrence. We examined its photothermal performance and in vitro and in vivo antibacterial ability; revealed its protective immunomodulatory effect; verified its preventative effect on recurrent infections; and demonstrated the system’s safety.

Results

Rp@Al exhibits excellent photothermal properties with an effective elimination of methicillin-resistant
Staphylococcus aureus
(
MRSA
). In addition, Rp@Al enhances dendritic cell activation and further triggers a T helper 1 (T
H
1)/T
H
2 immune response, resulting in pathogen-specific immunological memory against recurrent
MRSA
infection. Upon second infection, Rp@Al-treated mice show significantly lower bacterial burden, faster abscess recovery, and higher survival under near-lethal infection doses than control mice.

Conclusions

This innovative multiplex system, with superior photothermal and immunomodulatory effects, presents great potential for the treatment and prevention of drug-resistant bacterial infections.

Graphical Abstract
Female directors in the boardroom and intellectual capital performance: Does the “critical mass” matter?
Authors: Javaid Hafiz Mustansar , Ain Qurat Ul , D’Ecclesia Rita
Published: April 2023

This research aims to investigate the influence of female directors on Intellectual Capital Performance (ICP) using a sample of manufacturing-listed companies in China. Our study investigates the link between having two or more female directors and the Modified Value-Added Intellectual Coefficient (MVAIC) methodology, employing the critical mass theory from 2004–2017. We find that having a critical mass of female directors (three or more) shows a significant positive impact on MVAIC and its components, including human capital efficiency, structural capital efficiency, relational capital efficiency, and physical capital efficiency, with physical capital being the critical driver. Our study reveals that the critical mass participation of female directors substantially influences the IC efficiency of privately owned companies compared to state-owned companies. Moreover, the number of female directors also affects the IC performance of manufacturing companies in multiple regions. Our findings support the validity of group classification identified by Kanter and Critical Mass Theory. To the best of our knowledge, this is one of the few pieces of research that studies the role of female board directors in IC performance and Chinese manufacturing firms using MVAIC as an IC measure.
Dietary behavior of video game players and esports players in Germany: a cross-sectional study
Authors: Soffner Markus , Bickmann Peter , Tholl Chuck , Froböse Ingo
Published: April 2023

Background

Video gaming and competitive gaming (esports) are gaining more and more recognition in society as well as in research. Increasingly, health-related topics are the focus of research on video game and esports players. Although video gaming is often associated with energy drinks and fast food, no studies have yet examined the players’ dietary behavior. Therefore, the aim of this cross-sectional study is to investigate the dietary behavior and additional health-related data of video game players and esports players in Germany.

Methods

Between July and October 2020, 817 participants (87.1% male; 24.2 ± 6.9 years), divided into video game players and esports players, were surveyed via an online questionnaire about their dietary, health, and gaming behaviors. Descriptive statistics were performed on all questions. To investigate statistically significant differences between video game players and esports players, the Mann–Whitney-U-Test and Kruskall-Wallis-Test were used. Partial Spearman correlations were used to examine possible associations between dietary behavior, health status, well-being, and video game playing time.

Results

Water was the primary source of fluid intake for the players (10.9 ± 7.0 l/week). The average weekly consumption of energy drinks was 0.4 ± 0.9 L. Energy drinks (rho = 0.14; p < 0.01) as well as soft drinks (rho = 0.14; p < 0.01) are positively correlated with the video game playing time. Participants ate 7.5 ± 10.4 servings of fast food per month, which has a positive association with video game playing time (rho = 0.13; p < 0.01). In contrast, vegetables (1.7 ± 1.6 servings/day) and fruits (0.9 ± 1.0 servings/day) are eaten almost daily.

Conclusion

In this survey, the dietary behavior of video game players and esports players is similar to that of the German general population. Nevertheless, there is a need for improvement. Especially energy drinks, which are already documented to have adverse health effects, should be limited. In addition, the consumption of fast food and meat should also be reduced, and healthier foods such as fruits and vegetables should be increased instead. Early education and support regarding the associated risks with unhealthy foods is important within the target group.
Re-examining content validity of the BREAST-Q more than a decade later to determine relevance and comprehensiveness
Authors: Kaur Manraj N. , Chan Sabrina , Bordeleau Louise , Zhong Toni , Tsangaris Elena , Pusic Andrea L. , Cano Stefan J. , Klassen Anne F.
Published: April 2023

Purpose

The BREAST-Q is the most used patient-reported outcome measure (PROM) in breast cancer surgery. The purposes of this study were to re-examine the content validity of BREAST-Q cancer modules (mastectomy, lumpectomy and reconstruction) and to determine the need for new scales.

Methods

Interviews were conducted with women with breast cancer (Stage 0–4, any treatment), and were audio-recorded and transcribed verbatim. Deductive (based on original BREAST-Q conceptual framework) and inductive (new codes from the data) content analysis approaches were used to analyze the data. The number of codes that mapped to BREAST-Q were recorded.

Results

Dataset included 3948 codes from 58 participants. Most of the breast (n = 659, 96%) and all psychosocial (n = 127, 100%), sexual (n = 179, 100%) and radiation-related (n = 79, 100%) codes mapped to BREAST-Q Satisfaction with Breast, Psychosocial Wellbeing, Sexual Wellbeing and Adverse Effects of Radiation scales, respectively. For the physical wellbeing codes (n = 939) for breast/chest and arm, 34% (n = 321) mapped to the Physical Wellbeing-Chest scale. Most of the abdomen codes (n = 311) mapped to Satisfaction with Abdomen (n = 90, 76%) and Physical Wellbeing-Abdomen (n = 171, 89%) scales. Codes that did not map (n = 697, 30%) covered breast sensation and lymphedema. Concerns related to fatigue, cancer worry, and work impact were most reported and did not map to BREAST-Q.

Conclusion

The BREAST-Q, which was developed using extensive patient input more than a decade ago, is still relevant. To ensure the BREAST-Q remains comprehensive, new scales for upper extremity lymphedema, breast sensation, fatigue, cancer worry, and work impact were developed.
Seasonal fluctuations of antioxidant enzymes and biochemical compositions of Apis mellifera adansonii L. from three ecological zones of Nigeria
Authors: Bamidele Julius Akolawole , Idowu Adewumi Babatunde , Ademolu Kehinde Olutoyin , Osipitan Adedoyin Adebola , Rahman Samson Adisa
Published: April 2023

Background

The ability of honeybees to survive and sustain honey production depends on their ability to adapt to their environment. This study evaluated the seasonal fluctuations of antioxidant activities and biochemical compositions of honeybees,Apis mellifera adansoniiL. from rainforest, guinea savannah and derived savannah zones of Nigeria during three seasonal periods (onset of rain, wet season and dry season) from January to December, 2017. Honeybees were collected from fully colonized colonies of two different apiaries from each of the ecological zones during the seasonal periods. Amino acid composition was determined using high-performance liquid chromatography. Antioxidant enzymes activity, body protein, glucose and lipid profile were evaluated using standard protocols.

Results

Seasonal periods showed significant (p < 0.05) effect on the eighteen amino acids, superoxide dismutase (SOD), triglycerides and fat-free nitrogen recorded in the honeybees. Amino acids were higher in the honeybees from the rainforest zone, regardless of the seasonal period. SOD and body protein were higher during the wet season in the three ecological zones. However, seasonal periods showed no significant (p > 0.05) influence on the body glucose, protein pattern, total cholesterol, activities of malondialdehyde, reduced glutathione, glutathione peroxidase and catalase. Body glucose content in the honeybees from the rainforest and guinea savannah zones was highest during the dry season.

Conclusions

Antioxidant activities and biochemical compositions of honeybees are differently affected by both ecological zones and seasonal fluctuations.
Infective endocarditis and stroke: when does it bleed? A single center retrospective study
Authors: Nitsch L. , Shirvani Samani O. , Silaschi M. , Schafigh M. , Zimmer S. , Petzold G. C. , Kindler C. , Bode F. J.
Published: April 2023

Background

Infective endocarditis (IE) is a serious condition with a high mortality, represents a rare cause of stroke and an increased risk of intracranial hemorrhage. In this single center study, we characterize stroke patients with IE. We were interested in risk factors for intracranial hemorrhage and outcome of patients with intracranial hemorrhage compared to patients with ischemic stroke.

Methods

Patients with IE and symptomatic ischemic stroke or intracranial hemorrhage admitted to our hospital between January 2019 and December 2022 were included in this retrospective study.

Results

48 patients with IE and ischemic stroke or intracranial hemorrhage were identified. 37 patients were diagnosed with ischemic stroke, 11 patients were diagnosed with intracranial hemorrhage. The intracranial hemorrhage occurred within the first 12 days after admission. We identified Staphylococcus aureus detection and thrombocytopenia as risk factors for hemorrhagic complications. An increased in-hospital mortality in patients with intracranial hemorrhage (63.6% vs. 22%, p = 0.022) was found, whereas patients with ischemic stroke and patients with intracranial hemorrhage do not differ regarding favorable clinical outcome (27% vs. 27.3%, p = 1.0). 27.3% patients with intracranial hemorrhage and 43.2% patients with ischemic stroke underwent cardiac surgery. Overall, 15.7% new ischemic strokes occurred after valve reconstruction, whereas no new intracranial hemorrhage was observed.

Conclusions

We found an increased in-hospital mortality in patients with intracranial hemorrhage. Beside thrombocytopenia, we identified S. aureus detection as a risk factor for intracranial hemorrhage.