bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosis of atherosclerosis based on pulse wave and ensemble learning method: Weighted-Ensemble model
Authors: Chen Rongbin , Liu Wenjun , Huang Hui , Bai Songtao
Published: April 2022

Purpose: Atherosclerosis (AS) is closely related to cardiovascular disease (CVD). Nowadays, many scholars have conducted research on CVD, but the diagnosis of AS can only be diagnosed based on traditional medical methods. Pulse wave velocity (PWV) can evaluate potential AS. As a new technology, ultrafast pulse wave velocity (ufPWV) can accurately evaluate PWV. This research aims to screen out relevant features through feature engineering methods and build a Weighted-Ensemble model based on these features to predict AS, which can assist doctors in making more effective diagnosis of atherosclerosis. Methods: In this paper, the traditional statistical analysis method and Random forests (RF) are used to ensemble selection characteristics. This paper improves the ensemble model and applies it to the prediction of AS. Based on the idea of bagging, the base model of RF is changed, and all decision trees in RF are replaced with prediction models with better generalization ability. In order to make full use of models with high generalization ability, this study will also introduce a boosting strategy to weight each base model to form a Weighted-Ensemble model with high generalization ability. The accuracy (ACC), sensitivity (TPR), specificity (TNR) and AUC are four evaluation criteria to evaluate the model.Results: There are 37 features in the data set. Based on the statistical analysis of the data set, a total of 16 characteristics affect the diagnosis of AS. According to the importance of the features obtained by RF model, the 10 most important features are used to construct a Weighted-Ensemble model. The results show that the ACC, TPR, TNR and AUC of the Weighted-Ensemble model are 0.91, 0.93, 0.89 and 0.91 respectively. Compared with each model, the ACC, TPR and AUC of the Weighted-Ensemble model are better than other models. The analysis shows that the Weighted-Ensemble model is superior to traditional machine learning methods in distinguishing patients as normal or atherosclerosis. Conclusions: The accuracy of the algorithm based on the Weighted-Ensemble model in predicting AS has been confirmed in this paper, which implicates that the Weighted-Ensemble model can be successfully used in the atherosclerosis diagnosis and decision-making system.
Hindlimb unloading induces time-dependent disruption of testicular histology in mice
Authors: Ranade Anu V , Qaisar Rizwan , Karim Asima , Azeem Muhammad , Jose Josemin , Ramachandran Gopika , Ibrahim Zainab , Elmoselhi Adel , Ahmad Firdos , Hassan Wael A Rahman
Published: April 2022

Objectives: Mechanical unloading of the body in the hindlimb unloaded (HU) mice induces pathology in multiple organs, but the effects on testes are poorly characterized. We investigated the histology and Raman spectroscopy of the mouse testes following HU condition. Methods: We divided male, c57BL/6j mice into ground-based controls or experimental groups for two and four weeks of HU. The testes tissues were dissected after euthanasia to investigate histological and Raman spectroscopic analysis.Results: We found an HU-induced atrophy of testes irrespective of the time duration (p < 0.05). Histological analysis revealed that the HU induced epithelial thinning, luminal widening, and spermatozoa decline in the seminiferous tubules of the mouse testes. In addition, we found a thickening of the epididymal epithelia and tunica albuginea. These changes were accompanied by a generalized depression in the Raman spectra, indicating an altered concentration and/or orientation of several molecules. We also report reduced signal intensities of hydroxyproline and tryptophan, potentially contributing to testicular pathology during HU. Conclusion: Taken together, our findings indicate that the two or four weeks of HU induce disruption of testicular architecture and molecular phenotypes. Our results may have implications for understanding and/or treating male infertility associated with prolonged bed rest and spaceflight.
Identification and validation of a novel LncRNA TRG-AS1 that inhibits colorectal cancer proliferation and glycolysis
Authors: Li Lu , Zhang Yong , Li Kunkun , Xing Mengxuan , Xiao Xingguo , Zhang Li , Chu Feifei , Wu Huili
Published: April 2022

Abnormal glycolytic metabolism is one of the hallmarks during progression of malignant human colorectal cancer. Abundant evidence has illustrated that long non-coding RNA participated in glycolytic metabolism of various tumors. However, the lncRNA involved in the inhibition of glycolysis in CRC is largely unknown. In this study, we identified the lncRNA TRG-AS1 that inhibits CRC glycolysis in CRC by bioinformatic analysis, and its biological function was investigated in vitro and in vivo. LncRNA TRG-AS1 was identified and analyzed in The Cancer Genome Atlas database and Gene Expression Omnibus databases, and further confirmed in CRC tissues and adjacent normal tissues with qRT-PCR. TRG-AS1 overexpressing stable cell line and silence the target gene cell line were generated. Glucose assay kits and Pyruvate assay kits were utilized to analyze glycolysis. The cell proliferation ability was evaluated by CCK8, Colony formation assays and EdU. Xenograft tumor experiments were performed to assess proliferative capacity. Cell migration and invasion abilities were examined using the Transwell assay. TRG-AS1 was remarkably decreased in CRC tissues and cell lines. Higher TRG-AS1 expression is remarkably associated with more prolonged survival time. Over-expression of TRG-AS1 suppressed glycolysis, cell proliferation, invasive and migration abilities of CRC cells. On the contrary, TRG-AS1 silence attenuated CRC cells glycolysis, promoted cell proliferation, migration and invasion. Collectively, the results demonstrate that TRG-AS1 functioned as a tumor suppressor to contribute to CRC progression, is a promising prognostic factor. Our study provided a novel insight into the pathogenesis of CRC and a promising therapeutic target for CRC treatment.
The efficacy and safety of regional citrate anticoagulation centrifugal plasma exchange is equivalent to those of systemic heparin anticoagulation membrane plasma exchange in patients with liver failure: a single center retrospective cohort study
Authors: Zhu Xin-Fang , Li Jia-Qiang , Liu Tian-Tian , Wang Yuan , Zhong Yao , Gao Qin-Mei , Zhang Qi , Yu Kang-Kang , Huang Chong , Li Ning , Lu Qin , Zhang Wen-Hong , Zhang Ji-Ming , Xia Rong , Zheng Jian-Ming
Published: April 2022

Background: The purpose of this study is to compare with the efficacy and safety of regional citrate anticoagulation centrifugal plasma exchange and systemic heparin anticoagulation membrane plasma exchange in patients with liver failure.Methods: This study was a single center and retrospective study. All enrolled liver failure patients were treated with therapeutic plasma exchange. The patients treated by regional citrate anticoagulation centrifugal plasma exchange were defined as RCA group and those treated by systemic heparin anticoagulation membrane plasma exchange were defined as heparin group, respectively. Survival and clinical characteristics, including patients’ age, gender, total bilirubin, serum creatinine, international normalized ratio, platelet count, types of liver failure, arterial blood gas analysis, the model for end-stage liver disease (MELD) score, and occurrence of complications were compared between the two groups. Survival analyses of two groups and subgroups classified by MELD score were performed by Kaplan-Meier method and were compared by the log-rank test.Results: There were 69 patients enrolled in this study, 51 patients in RCA group and 18 patients in heparin group respectively. In overall patients, the 28-day mortality rate was 41% in RCA group and 39% in heparin group (P > 0.05). The 90-day mortality rate was 59% in RCA group and 50% in heparin group (P > 0.05). MELD best-fit value is 30, and area under the ROC curve is 0.7208 in the transplantation free patients with liver failure in both RCA group and heparin group. There was no significant difference in the occurrence of complications between the two groups.Conclusions: In conclusion, our study demonstrates that the efficacy and safety of regional citrate anticoagulation centrifugal plasma exchange is equivalent to those of systemic heparin anticoagulation membrane plasma exchange in patients with liver failure. RCA plasma exchange at an interval of 48 hours in patients with acute or acute-on-chronic liver failure may be an effective in reducing the occurrence of the complication of citrate accumulation. RCA centrifugal plasma exchange treatment can achieve a good prognosis and well tolerance, especially in MELD<30 patients with liver failure.
Similarity Learning and Visualization with Siamese Topological Networks
Authors: Hartono Pitoyo
Published: April 2022

In this study a model of Siamese topological neural networks, which consisted of a pair of hierarchical neural networks each with a lowdimensional internal layer, is proposed. Through similarity learning, the objective of the proposed siamese network is to learn low-dimensional topological representations of a given similarity between pairwise highdimensional inputs. The low-dimensionality of the internal layer allows human to visualize the structure of the high-dimensional data in the context of their similarities, for example, label-similarity or ranksimilarity. Different from many similarity learning techniques, dimensionality reduction is integrated in the proposed siamese networks allowing flexible context-oriented visualization analysis for high-dimensional data.
Physicochemical, microbiological, and sensory quality of industrialized and fresh coconut water commercialized in Petrolina, Pernambuco
Authors: Dias Carlos Henrique Araujo , França Dairan Santos , Borges Monica Cristina Rezende Zuffo , de Souza Rita de Cássia Rodrigues , Martins Marlos Gomes
Published: April 2022

Coconut water is widely consumed in Brazil. However, due to its nutritional qualities, this product is susceptible to microbiological contamination when good hygiene practices are not adopted. From this perspective, this study aimed to evaluate the physicochemical and microbiological quality of industrialized and fresh coconut water samples purchased in the municipality of Petrolina-PE, and perform the sensory analysis of the studied samples. The microbiological properties were analyzed by evaluating the concentration of total and thermotolerant coliforms, Escherichia coli, Salmonella ssp., molds, and yeasts, whereas the physicochemical properties were analyzed by evaluating the pH, total titratable acidity, ash content, and turbidity. The sensory analysis was performed by an acceptance test using a 9-point hedonic scale. The results of the evaluations demonstrated that all samples were within the standards of the current regulations. However, the presence of total coliforms and molds suggests that the products were contaminated by fecal material and/or had problems in the production process, which could result in health damage to consumers. Sensory evaluation revealed that fresh coconut water was preferred among tasters. In this scenario, it is essential to adopt good practices among traders and bottling companies and greater participation of the public sector to ensure the quality of food products commercialized in the region, thus reducing the risks associated with the consumption of contaminated foods.
Predicting the depressive status using empirical dietary inflammatory index in patients with antineutrophil cytoplasmic antibody-associated vasculitis
Authors: Lee Joo Hye , Yun Jan-Di , Whang Jeong Yeop , Pyo Jung Yoon , Ahn Sung Soo , Song Jason Jungsik , Park Yong-Beom , Lee Sang-Won
Published: April 2022

Background: This study investigated whether the empirical dietary inflammatory index (eDII) score is associated with the inflammatory burden as well as the depressive status in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).Methods: Eighty-four patients with AAV participated in this study. Birmingham vasculitis activity score (BVAS) and short-form 36-item Health Survey mental component summary (SF-36 MCS) were considered as indices assessing the inflammatory burden and depressive status, respectively. The eDII includes 16 food components and consists of three groups: -9 to -2, the low eDII group; -1 to +1, the moderate eDII group; and +2 to +10, the high eDII group. Furthermore, the lower eDII group includes both the low and moderate eDII groups.Results: The median age was 64.5 years (36 men). The eDII scores inversely correlated with SF-36 MCS (r = -0.298, P = 0.006) but not with BVAS. SF-36 MCS significantly differ between the lower and higher eDII groups (69.7 vs. 56.7, P = 0.016), but not among the low, moderate, and high eDII groups. Additionally, when patients with AAV were divided into two groups according to the upper limit of the lowest tertile of SF-36 MCS of 55.31, patients in the higher eDII group exhibited a significantly higher risk for the lowest tertile of SF-36 MCS than those in the lower eDII group (RR 3.000). Conclusion: We demonstrated for the first time that the eDII could predict the depressive status by estimating SF-36 MCS without utilising K-CESD-R ≥ 16 in patients with AAV.
Clinicopathologic and Molecular Characteristics of Hepatoid Adenocarcinoma of Bladder: a case report
Authors: Wang Jianjun , Shi Na , Niu Fengnan , Fu Yao , Fan Xiangshan
Published: April 2022

Background
Hepatoid adenocarcinoma of bladder (HACD) is extremely rarely reported. Only 10 cases of HACD have been reported to date in English literature and no molecular analyses of HACD have ever been reported
Case presentation:
This case was a 57-year-old man who complained of gross hematuria for 5 days and urinary tract ultrasound examination revealed a hypoechoic mass at the right lateral wall of the bladder. 10 months later, the tumor recurred and transurethral resection was performed again. Definitive diagnosis of HACD was made by morphological and immunohistochemical analysis. A comparison was made between those two resections by the next generation sequencing (NGS). Somatic mutations of TP53, RB1 and KMT2D and amplifications of CCND1 and FGFR1 were identified in both resections. FGFR3 amplification was detected in the recurrent resection.
Conclusions
Detection of amplifications of FGFR1 and FGFR3 suggests that the FGFR pathway may play an important role in HACD and could be a candidate for personalized treatment. In this report, we provide some useful molecular clues to the analysis of HACD, while the mechanism and treatment still need to be explored.
Reproducibility and validity of a culture specific food frequency questionnaire for assessing dietary intake in the adult population of Trinidad and Tobago
Authors: Foster-Nicholas Lesley Ann , Shavlik David , Heskey Celine , Dyett Patricia , Segovia-Siapco Gina
Published: April 2022

Background
Nutritional epidemiologists use culture-specific food frequency questionnaires (FFQs) to assess the dietary intake of groups based on country, region or ethnic groups. The aim of this study was to assess the performance of a self-constructed culture-specific semi-quantitative electronic FFQ (e-FFQ) in assessing food group intake estimates when compared with multiple 1-day food records (FRs) for the adult population of Trinidad and Tobago.
Methods
The 139-item semi-quantitative e-FFQ containing local dishes and street foods was created using Google forms. It was emailed twice, 3 months apart, to 91 participants ≥ 18 years of age. The first administration of the e-FFQ was validated against 4-four one-day FRs with digital photographs which served as the reference method. Using SPSS Version 26, the validity and reproducibility of the FFQ’s food group intake estimates were determined using paired t-tests, bivariate correlations, and cross-classifications. Cross-classification and Bland-Altman plots were used to show agreement between the e-FFQ and weighted mean of the FRs.
Results
Participants consisted of 22% males and 78% females, mean age 38 ± 9.6 years. Reproducibility correlations between the reported food group intakes in the first and repeat administration of the e-FFQ ranged from moderate (r = 0.44 p ≤ 0.0001) for sweetened beverages to high (r = 0.91 p ≤ 0.0001) for alcohol. Cross-classification agreements within ± 1 quintile ranged from 70% (street foods) to 92% (alcohol). Crude validity correlations between the e-FFQ and FR ranged from (r = 0.06) for sweets to (r = 0.65) for food from animal sources, with mean of the validity correlations being 0.34. Deattenuated correlations ranged from r = 0.11 for sweets to r = 0.81 for food from animal sources. Cross-classification showed that an average of 68% of the FFQ estimates were correctly classified within ± 1 quintile of exact agreement in the FRs. Agreements between the FFQ and the FRs ranged from 55% for street foods to 95% for water, all significant at p ≤ 0.0001.
Conclusions
The study shows that this culture-specific e-FFQ is highly reproducible and is a reasonably valid tool to assess and rank food group intake estimates of an adult population living in Trinidad and Tobago. Thus, it can be used to examine associations between dietary intakes and NCDs.
Distant metastasis and recurrence according to radial resection margin and perineural invasion status after curative surgery and adjuvant chemotherapy in rectal cancer: A comparative matching analysis
Authors: Sung Soo-Yoon , Kim Sung Hwan , Lee Joo Hwan , Lee Hyo Chun , Jang Hong Seok , Jeong Songmi , Yu Mina , Lee Jong Hoon
Published: April 2022

Purpose: The exact role of adjuvant chemotherapy has yet to be elucidated in rectal cancer after preoperative chemoradiotherapy (CRT) and total mesorectal excision (TME). Thus, we assess the significance of positive surgical margin and perineural invasion (PNI) associated with adjuvant chemotherapy in patients with rectal cancer.Methods: This multi-institutional retrospective study included 1799 patients with rectal cancer at cT3-4N0-2M0. All patients received preoperative CRT with a dose of 50.4 Gy and curative TME. Patients were divided into two groups according to the status of surgical margin and PNI. The high-risk group had a positive margin and/or perineual invasion. The low-risk group showed no positive margin or PNI. Propensity-score matching analysis was performed to balance baseline characteristics of the two groups, and a total of 928 patients with 464 in each arm were evaluated.Results: The high-risk group showed significant differences in overall survival (OS, 73.4% vs. 53.9%, P < 0.01) and recurrence-free survival (RFS, 52.7% vs. 40.9%, P = 0.01) at five years between the adjuvant chemotherapy arm and observation arm. The low-risk group showed no significant differences in 5-year OS (86.6% vs. 75.3%, P = 0.61) and RFS (66.9% vs. 53.1%, P = 0.75) between the two arms. Multivariate analyses showed that age, pathologic N stage, and adjuvant chemotherapy were significantly correlated with OS and RFS in the high-risk group (all P < 0.05).Conclusion: Adjuvant chemotherapy improved OS and RFS more significantly in rectal cancer patients with positive surgical margin or PNI than in those with negative surgical margin and PNI.
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance - the case of S100B
Authors: Murcko Robert , Marchi Nicola , Bailey Damian , Janigro Damir
Published: April 2022

Blood biomarkers of neurological diseases are often employed to rule out or confirm the presence of significant intracranial or cerebrovascular pathology or for the differential diagnosis of conditions with similar presentations (e.g., hemorrhagic vs. embolic stroke). More widespread utilization of biomarkers related to brain health is hampered by our incomplete understanding of the kinetic properties, release patterns, and excretion of molecules derived from the brain. This is, in particular, true for S100B, an astrocyte-derived protein released across the blood-brain barrier (BBB). We developed an open-source pharmacokinetic computer model that allows investigations of biomarker’s movement across the body, the sources of biomarker’s release, and its elimination. This model was derived from a general in silico model of drug pharmacokinetics adapted for protein biomarkers. We improved the model's predictive value by adding realistic blood flow values, organ levels of S100B, lymphatic and glymphatic circulation, and glomerular filtration for excretion in urine. Three key variables control biomarker levels in blood or saliva: blood-brain barrier permeability, the S100B partition into peripheral organs, and the cellular levels of S100B in astrocytes. A small contribution to steady-state levels of glymphatic drainage was also observed; this mechanism also contributed to the uptake of organs of circulating S100B. This open-source model can also mimic the kinetic behavior of other markers, such as GFAP or NF-L. Our results show that S100B, after uptake by various organs from the systemic circulation, can be released back into systemic fluids at levels that do not significantly affect the clinical significance of venous blood or salivary levels after an episode of BBB disruption.
Estimation of nonadditive and additive genetic effects on growth traits of Horro cattle
Authors: Goshu Habtamu Abera
Published: April 2022

The estimation of nonadditive genetic effects plays a significant role in the accuracy of estimated breeding values of growth traits. Data for genetic estimation of individual and maternal heterosis of crossbreed cattle in Ethiopia are limited to research institutions and universities. This paper aims to estimate the crossbreeding effects on the growth performances of Holstein FriesianམHorro and JerseyམHorro crosses in Ethiopia. The data used in the study included pedigree and weight data of animals born between 1980 and 2008. Heritability of growth traits were estimated using restricted maximum likelihood (ASREML). However, the additive, maternal, and heterosis effects of the crosses were estimated using the crossbreeding effects (CBE3) package and fitting Kinghorn’s Model one for growth traits. The direct and maternal heritability estimates for one-year weight, for the best model, which included the direct maternal covariance were 0.77 ± 0.12 and 0.26 ± 0.09, respectively. Individual heteroses estimated for Jersey and Holstein Friesian were significantly high and positive for one year weight (21.6 ± 6.7 and 26.0 ± 3.9 kg), pre-weaning average daily gain (27.4 ± 26 and 28.9 ± 15 g), and post-weaning average daily gain (68.8 ± 16.6 and 61.8 ± 9.9 g), respectively. The maternal additive effect for growth traits was mostly positive; therefore, it may be preferable to use crossbred cows resulting from purebred dams instead of using crossbred cows from crossbred dams. Significantly higher heterosis and additive parameters in Holstein FriesianམHorro crosses showed that crossbreeding of Horro with Holstein Friesian may be advisable in the areas of Horro cattle breeds occupied.
Comparison between intraocular pressure profiles over 24 and 48 hours in the diagnosis of glaucoma
Authors: Keye Philip , Boehringer Daniel , Anton Alexandra , Reinhard Thomas , Luebke Jan
Published: April 2022

Purpose: To assess the additional value of 48-hour diurnal-nocturnal IOP profiles in comparison to only 24-hour diurnal-nocturnal IOP profiles in the management of glaucoma.Methods: All diurnal-nocturnal IOP profiles over 48 hours that were taken between 2017 and 2019 for diagnostic purposes in glaucoma patients at our hospital were reviewed. We counted elevated IOP values (>21 mmHg), higher short-term IOP fluctuations (> 6 mmHg) and nocturnal IOP peaks (measured at midnight and at 7 AM in supine position). In a second step, we repeated this analysis in the same profiles but censored the data to the first 24-hours. We compared the outcome rates by means of the Chi2-Test. Results: 661 IOP profiles were included. 59% of 48-hour IOP profiles revealed IOP values above 21 mmHg and 87% showed IOP fluctuation greater than 6 mmHg. Nocturnal peaks in supine position could be observed in 51% of the patients. In the profiles censored to the first 24 hours, the fractions were 50%, 71% and 48%, (p < 0,01, p < 0,01 and p = 0,12) respectively. Conclusion: Our data suggest that 48-hour diurnal-nocturnal IOP profiles are superior in identifying patients with clinically meaningful IOP events in comparison to observing the patients for only 24-hours. It is likely that the higher accuracy is worth the additional socioeconomic costs resulting from the prolonged inpatient stay.
Secondary ion mass spectrometer analyses for trace elements in glass standards using variably charged silicon ions for normalization
Authors: Carlson Eric N. , Hervig Richard L.
Published: April 2022

Trace element analyses of silicate materials by secondary ion mass spectrometry (SIMS) typically normalize the secondary ion count rate for the isotopes of interest to the count rate for one of the silicon isotopes. While the great majority of SIMS analyses use the signal from Si+, some laboratories have used a multiply charged ion (Si2+ or Si3+). We collected data and constructed calibration curves for lithium, beryllium, and boron using these different normalizing species on synthetic basaltic glass and soda-lime silicate glass standards. The calibrations showed little effect of changing matrix when Si+ was used, but larger effects (up to a factor of ~2) when using Si2+ or Si3+ are a warning that care must be taken to avoid inaccurate analyses. The smallest matrix effects were observed at maximum transmission compared to detecting ions with a few tens of eV of initial kinetic energy (“conventional energy filtering”). Normalizing the light element ion intensities to Al3+ showed a smaller matrix effect than multiply-charged Si ions. When normalized to 16O+ (which includes oxygen from the sample and from the primary beam), the two matrices showed distinct calibration curves, suggesting that changing sputter yields (atoms ejected per primary atom impact) may play a role in the probability of producing multiply charged silicon ions.
Thermalization and hydrodynamics of two-dimensional quantum field theories
Authors: Delacrétaz Luca , Fitzpatrick Andrew Liam , Katz Emanuel , Walters Matthew
Published: April 2022

We consider 2d QFTs as relevant deformations of CFTs in the
thermodynamic limit. Using causality and KPZ universality, we place a
lower bound on the timescale characterizing the onset of hydrodynamics.
The bound is determined parametrically in terms of the temperature and
the scale associated with the relevant deformation. This bound is
typically much stronger than \frac{1}{T}1T,
the expected quantum equilibration time.
Subluminality of sound further allows us to define a thermodynamic
CC-function,
and constrain the sign of the T\bar TTT‾
term in EFTs.
Loan restructuring as a banking solution in the COVID-19 pandemic: Based on contingency theory
Authors: Gusti Ayu Eka Damayanthi I , Luh Putu Wiagustini Ni , Wayan Suartana I , Rahyuda Henny
Published: April 2022

The world’s economic growth has decreased due to the COVID-19 pandemic. Many companies are experiencing financial distress, so they cannot pay off their maturing debts. Banks as lenders face the risk of non-performing loans. The increasing number of unpaid loans will reduce a bank’s operating income and gain. The contingency approach is used as a conditional factor that can increase the effectiveness of firm performance. The relevance of this study is how banking strategies overcome the problem of uncertainty regarding risk and return during a pandemic. Contingency theory describes organizational success as influenced by contextual factors and established strategies. The purpose of this study is to systematically review the literature related to loan restructuring as a solution to non-performing loans in banking companies in Indonesia. The research method is a review of 40 articles from Scopus and a descriptive analysis of company financial statement notes to see what strategies banks are using during the COVID-19 pandemic. Based on contingency theory, the results of the study explain organizational success which is influenced by contextual factors and the established strategy. The more appropriate the strategy chosen in a given situation, the higher the achievement of organizational performance. A qualitative analysis provides a solution for a bank to overcome the problem of unpaid loans at maturity through a restructuring model strategy with modified loan terms.
Job satisfaction in the light of gender in the engineering sector in Slovakia
Authors: Živčicová Eva , Masárová Tatiana , Gullerová Monika
Published: April 2022

Job satisfaction covers all factors affecting a particular work activity. Gender is one of the internal job satisfaction factors. The purpose of the paper was to find job satisfaction differences related to gender in selected characteristics of employees working in the engineering sector. A questionnaire method was used to conduct the survey. Questionnaire items were selected from the questionnaire developed by Paul E. Spector (1994) and the Minnesota Satisfaction Questionnaire (MSQ). The respondents were employed in a Slovak engineering company, and the sample consisted of 60 respondents with balanced basic and specific characteristics. Paper questionnaires were distributed to the respondents while observing all the ethical rules of the survey. The results are expressed in means, standard deviations and p-values. In addition, a two-sample t-test was used. It was found that job satisfaction is perceived differently by male and female workers in the areas examined. Statistically significant differences were established in the areas of remuneration, recognition, and use of one’s abilities at work. Statistically insignificant areas of job satisfaction include meaninglessness of work, experiencing happiness at work more than others, and satisfaction with the relationship with supervisors.
AcknowledgmentThe paper was written under the project Multiplier Effects of Human Capital Quality on Economic Performance and Competitiveness of the Slovak Economy and supported by the Grant Agency VEGA of the Ministry of Education, Science, Research and Sport of the Slovak Republic [No. 1/0357/21].
PEMBELAJARAN KOOPERATIF PENGISIAN E-FILING BAGI PELAKU UMKM DI KELURAHAN CIPADU-CILEDUG-TANGERANG
Authors:   Akuntansi, Politeknik Keuangan Negara STAN, Trisulo Trisulo , Indrawati Iin ,   Akuntansi, Politeknik Keuangan Negara STAN
Published: April 2022

The Directorate General of Tax (DGT) developed various applications to facilitate taxpayers in carrying out tax obligations through e-filing. There are still many taxpayers who do not understand e-filing so come to the tax office to report the tax return. Yet by utilizing e-filing, time and cost can be more productive. UMKM is a new potential in increasing tax contributions. The government through several regulations is aiming at efforts to increase taxation from the UMKM sector. One of them is the reduction of UMKM tax rates from 1% to 0.5%. The problem of understanding and awareness of taxpayers is the key to the success of these efforts. A special strategy is needed to educate the UMKM community. This is a form of mutual responsibility between the people and the government. Some obstacles in taxation socialization include filling e-filing for tax reporting purposes. Difficulties were found in the field in providing socialization material to UMKMs related to tax obligations. Jigsaw type Cooperative Learning in e-filing filling is an effort to increase the taxation potential of the UMKM sector, as well as evidence of government responsibility in public services.
Current Debates on Etiopathogenesis and Treatment Strategies for Vitiligo
Authors: Singh Shamsher , Chaudhary Ankit , Patel Mayank
Published: April 2022

Vitiligo is an acquired, chronic, and progressive depigmentation or hypopigmentation, characterized by the destruction of melanocytes, and occurrence of white patches or macules in the skin, mucosal surface of eyes, and ears. Melanocytes are the melanin pigment producing cells of the skin which are destroyed in pathological conditions called vitiligo. Approximately, 0.5 - 2.0% of the population is suffering from vitiligo, and a higher prevalence rate up to 8.8% has been reported in India. It is caused by various pathogenic factors like genetic predisposition, hyperimmune activation, increased oxidative stress, and alteration in neuropeptides level. Genetic research has revealed a multi-genetic inheritance that exhibits an overlap with other autoimmune disorders. However, melanocytes specific genes are also affected (such as DDR1, XBP1, NLRP1, PTPN22, COMT, FOXP3, ACE, APE, GSTP1, TLR, SOD, and CTLA-4). The numbers of therapeutic options are employed for the treatment of vitiligo. The topical corticosteroids and immunomodulators are currently in practice for the management of vitiligo. Phototherapies alone, and in combinations with other approaches are used in those patients who do not respond to the topical treatment. The main focus of this review is on the etiopathological factors, pharmacological management (phototherapy, topical, systemic and surgical therapy), and herbal drugs use to treat vitiligo.
The New Era of Drug Discovery: The Power of Computer-aided Drug
Design (CADD)
Authors: Nascimento Igor José dos Santos , de Aquino Thiago Mendonça , da Silva-Júnior Edeildo Ferreira
Published: April 2022

Drug design and discovery is a process that requires high financial costs and is timeconsuming.
For many years, this process focused on empirical pharmacology. However, over the years,
the target-based approach allowed a significant discovery in this field, initiating the rational design era. In
view, to decrease the time and financial cost, rational drug design is benefited by increasing computer
engineering and software development, and computer-aided drug design (CADD) emerges as a promising
alternative. Since the 1970s, this approach has been able to identify many important and revolutionary
compounds, like protease inhibitors, antibiotics, and others. Many anticancer compounds identified
through this approach have shown their importance, being CADD essential in any drug discovery campaign.
Thus, this perspective will present the prominent successful cases utilizing this approach and entering
into the next stage of drug design. We believe that drug discovery will follow the progress in bioinformatics,
using high-performance computing with molecular dynamics protocols faster and more effectively.
In addition, artificial intelligence and machine learning will be the next process in the rational design
of new drugs. Here, we hope that this paper generates new ideas and instigates research groups
worldwide to use these methods and stimulate progress in drug design.
Therapeutic Drug Monitoring as a Tool for Therapy Optimization
Authors: Pavithran Keechilat , Babu Merin
Published: April 2022

The use of pharmacotherapy for improving healthcare in society is increasing. A vast majority of patients have either received subtherapeutic treatment (which could result from low pharmacokinetics) or experienced adverse effects due to the toxic levels of the drug. The medicines used to treat chronic conditions, such as epilepsy; cardiovascular diseases; oncological, neurological, and psychiatric disorders, require routine monitoring. New targeted therapies suggest an individualized treatment that can slowly move practitioners away from the concept of a one-sizefits- all-fixed-dosing approach. Therapeutic drug use can be monitored based on pharmacokinetic, pharmacodynamic, and pharmacometric methods. Based on the experiences of therapeutic drug monitoring of various agents across the globe, we can look ahead to the possible developments of therapeutic drug monitoring in India.
Breast Cancer Segmentation in Mammogram Using Artificial Intelligence
and Image Processing: A Systematic Review
Authors: Raza Basit , Ansar Wajeeha
Published: April 2022

Background:

Breast cancer is the second leading cause of death in females worldwide.
Mammograms are useful in early cancer diagnosis as well when the patient can sense symptoms or
they become observable. Inspection of mammograms in search of breast tumors is a difficult task
that radiologists must carry out frequently.

Objective:

This paper provides a summary of possible strategies used in automated systems for a
mammogram, especially focusing on segmentation techniques used for cancer localization in
mammograms.

Methods:

This article is intended to present a brief overview for nonexperts and beginners in this
field. It starts with an overview of the mammograms, public and private available datasets, image
processing techniques used for a mammogram and cancer classification followed by cancer segmentation using the machine and deep learning techniques

Conclusion:

The approaches used in these stages are summarized, and their advantages and disadvantages with possible future research directions are discussed. In the future, we will train a model
of medical images that can be used for transfer learning in mammograms.
Pengaruh Efektivitas Iklan Youtube terhadap Brand Image
Authors:   Universitas Katolik Indonesia Atma Jaya, Helena Monique , Natalia El Chris
Published: April 2022

Advertising is used by companies as a way to market products and services. YouTube is currently the most popular social media in Indonesia and has become a platform of marketing the company's products and services. Head & Shoulders, which is under the auspices of the Procter & Gamble company uses YouTube in marketing and promoting its products. This research focuses on Joe Taslim's “Head & Shoulders” Bloopers YouTube ad. This study aims to determine the influence of the effectiveness of Joe Taslim's "Head & Shoulders" YouTube Bloopers ad on the formation of the company's brand image. The variable in this study is the effectiveness of advertising with dimensions, namely awareness, knowledge, likes, and choices. The brand image variable uses the dimensions of brand identity, brand personality, brand association, brand behavior and attitudes, as well as brand competence and benefits. This research uses an explanative quantitative method. The data was collected through survey methods and online questionnaires to 100 respondents. The result of the analysis indicates that there is a positive influence between Joe Taslim's “Head & Shoulders” YouTube Bloopers ad on the formation of the company's brand image.
Peran Produser dalam Proses Pemberitaan Pada Siaran Live Cross di LPP TVRI Bengkulu
Authors:   Universitas Bengkulu, Ramadhani Agnes , Budiman Dwi Aji , Sari Eka Vuspa
Published: April 2022

This research aims to find out the role of producers in the news process on the live cross broadcast on LPP TVRI Bengkulu, referring to the Role Theory by Soerjono Soekanto as well as the Theory of Gatekeeper models Bruce Wastley and Malcolm Maclean. The method used in this study is qualitative descriptive by collecting complete research data by participating directly related to the role of producers in the process of reporting live cross broadcasts at LPP TVRI Bengkulu. The technique of collecting informants in this study used a purposive sampling technique, namely a sampling technique by determining certain criteria. Data collection techniques are by interviews, observations, and documentation by collecting complete research data and also observing and participating in the role of producers in the news process on live cross broadcasts at LPP TVRI Bengkulu. The results of this study concluded that based on the theory of the role and role of the gatekeeper by a producer in a live cross broadcast, it is someone who has full authority and responsibility in decision making during a live cross broadcast. The live cross broadcast process is divided into 3 stages in which the producer plays a live role in all of these stages. Be it from the pre-implementation process which includes the assignment of reporters, news selection, news editing, and contacting the team in charge. In the implementation process, it is monitoring and coordinating the team on the ground. As well as the post-implementation process is the evaluation of the results of the team's overall work.
Молекулярная фотоника мономеров 3,3'-диэтил-9-метилтиакарбоцианина и димерных комплексов с кукурбит[8]урилом
Authors: Федотова Т.В. , Захарова Г.В. , Чибисов А.К.
Published: April 2022

A comparative study of the spectral-luminescent and spectral-kinetic properties of 3,3'-diethyl-9-methylthiacarbocyanine (MTCC) and 3,3'-diethylthiacarbocyanine (TCC) and their complexes with cucurbit[8]uril in aqueous solution was carried out. Dimeric complexes of TCC with cucurbit[8]uril consist of trans-isomers and exhibit only delayed fluorescence while dimeric complexes of MTCC consist of cis-isomers and exhibit both delayed fluorescence and phosphorescence in water. The dimeric complexes of MTCC and TCC with cucurbit[8]uril participate in the electron phototransfer reaction where the dimeric complex of MTCC exhibits a greater ability to enter into photooxidation reactions.
Особенности фотолюминесценции кислородонасыщенных пленок метокси-полифениленвинилена (MEH-PPV)
Authors: Кучеренко М.Г. , Пеньков С.А.
Published: April 2022

The effects of the influence of the magnetic field on the luminescence intensity of methoxypolyphenylene vinylene (MEH-PPV) films at various air pressures above the samples are investigated. An inversion of the sign of the magnetic field effect was detected with a smooth change in the oxygen concentration in the system. Based on the balance equations, a theoretical model of processes is proposed that takes into account the formation of populations of triplet (T) excitons of MEH-PPV and singlet oxygen during the reactions of triplet-triplet annihilation, T-{3}^Sigma_g(O_2)-quenching and T-{1}^Delta_g(O_2)-cross-annihilation of electronic excitations. According to the proposed theoretical model, the magnetic field effects of delayed fluorescence at different concentrations of O_2 molecules in MEH-PPV films are calculated, consistent with the experimental results.
Корреляция между эффективностью генерации синглетного кислорода и параметрами люминесценции фотосенсибилизаторов
Authors: Старухин А.С. , Романенко А.А. , Плавский В.Ю.
Published: April 2022

The quantum yield of interconversion to triplet states for free bases of 2,3,7,8,12,13,17,18-octaethylporphyrin and 5,10,15,20-tetraphenylporphyrin, as well as their metal complexes with Mg(II), Zn(II), Pd(II), and Pt(II) ions have been determined on the based on the data about efficiency of singlet oxygen generation. The quantum yields of singlet oxygen generation were measured for these compounds in several solvents. The maximum values of quantum yields of singlet oxygen generation are corresponding to compounds with heavy Pd(II) and Pt(II) ions, that is due to the high impact of the internal heavy atom on the spin-orbital coupling. High quantum yields of singlet oxygen generation for free bases of porphyrins indicate a significant role of spin-orbital coupling in the case without an internal heavy atom effect for these compounds. The effect of the internal heavy atom on the rates of deactivation of the lower triplet states for a porphyrins with Pd(II) and Pt(II) ions were detected at ambient and liquid nitrogen temperatures .
Influence of data pre-processing techniques for plsr model to predict blood glucose by nir spectroscopy-=SUP=-*-=/SUP=-
Authors: Suryakala S.Vasanthadev , Prince Shanthi
Published: April 2022

NIR diffuse reflectance spectroscopic spectra can be mathematically modelled to extract quantitative information by suitable multivariate calibration models. The analysis of spectral data becomes complex as the data is more prone to noise due to light scattering and baseline effects. These errors reduces the robustness and reliability of the developed calibration model. Hence data pre-processing becomes the most important aspect in data analysis. Different mathematical transformations are applied to remove the noise present in the data. This work focuses on the various empirical data pre-processing techniques like baseline correction, multiplicative scatter correction (MSC), robust MSC, extended multiplicative signal correction (EMSC), orthogonal signal correction (OSC) and (-log R) followed by standard normal variate (SNV) techniques for Partial Least Square Regression (PLSR) model in the prediction of blood glucose non-invasively. The performance of the PLSR model for the acquired (raw) spectral data and the same data subjected to different pre-processing techniques is analyzed. The model complexity and robustness is evaluated in terms of the number of latent variables (LVs) required to build the calibration model and obtained mean square prediction error after cross validation. This study utilizes the spectral data collected from 207 subjects from a diabetic center using Diffuse Reflectance Spectrometer (DRS). The analyzed results show that pre-processing based on (-log R) followed by SNV is found to perform well with reduced model complexity and minimum estimated mean square prediction error of 0.23 mg/dl among the other empirical pre-processing techniques. Keywords:
Лазерная перфорация водонасыщенных материалов
Authors: Юсупов В.И.
Published: April 2022

The mechanism of action of laser radiation during fiber perforation of water-saturated materials in the case when laser radiation is well absorbed in water is refined. It is shown that due to the explosive boiling of water in the pores, as well as a decrease in the tensile strength and an increase in the plasticity of the material, a layer of highly porous tissue is formed near the end of the laser fiber, which contributes to a significant increase in the perforation rate.
Исследование процессов теплопереноса в гидрогелях методами голографической интерферометрии и градиентной теплометрии
Authors: Захаров Н.С. , Покусаев Б.Г. , Вязьмин А.В. , Некрасов Д.А. , Сулягина О.А. , Мошин А.А.
Published: April 2022

The study of natural convection in structured optically transparent materials using pure and combined agarose-gelatin gels was carried out by optical holography. The article presents data on visualization of the occurrence and development of convective flows in such gels with non-stationary conductive heating from below. The similarities and differences of the conditions of heat transfer and the occurrence of convection in structured materials and droplet liquids are analyzed. For the first time experimentally obtained data on the effect of two interpenetrating and interacting structured media on the transition from conductive to convective heat transfer
Фазовые превращения в нержавеющей стали Сr-Mn-N, активированные наноструктурирующей поверхностной обработкой, и их влияние на деформационное поведение и разрушение при криогенной температуре
Authors: Наркевич Н.А. , Дерюгин Е.Е. , Власов И.В.
Published: April 2022

The structure of stainless austenitic Cr-Mn-N steel after deformation treatment of its surface by ultrasonic forging strain (UFS) has been studied. It is shown that UFS activates strain aging in the near-surface layer with the formation of CrN particles. Preliminary ultrasonic treatment of the steel surface contributes to an increase in the yield strength during tensile tests at a temperature of -196 ° C and provides ductile fracture of the near-surface layer.
Структура волны сжатия при плоском ударном деформировании монокристалла молибдена [100] с различной начальной плотностью дислокаций
Authors: Гаркушин Г.В. , Савиных А.С. , Разоренов С.В. , Парамонова И.В.
Published: April 2022

The features of the evolution of the elastic-plastic compression wave in Mo single crystals along the crystallographic plane [100], having a different initial dislocation structure formed by small deformations of varying degrees of static compression at room temperature, have been studied. The analysis of wave profiles recorded using the VISAR laser interferometer in samples of different thicknesses showed a non-monotonic change in the hugoniot elastic limit depending on the initial dislocation density – pre-strain of a single crystal by compression reduces the hugoniot elastic limit by 3 times.