bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential Toxicity Risk Assessment and Priority Control Strategy for PAHs Metabolism and Transformation Behaviors in the Environment
Authors: Zhao Lei , Zhou Mengying , Zhao Yuanyuan , Yang Jiawen , Pu Qikun , Yang Hao , Wu Yang , Lyu Cong , Li Yu
Published: September 2022

In this study, 16 PAHs were selected as the priority control pollutants to summarize their environmental metabolism and transformation processes, including photolysis, plant degradation, bacterial degradation, fungal degradation, microalgae degradation, and human metabolic transformation. Meanwhile, a total of 473 PAHs by-products generated during their transformation and degradation in different environmental media were considered. Then, a comprehensive system was established for evaluating the PAHs by-products’ neurotoxicity, immunotoxicity, phytotoxicity, developmental toxicity, genotoxicity, carcinogenicity, and endocrine-disrupting effect through molecular docking, molecular dynamics simulation, 3D-QSAR model, TOPKAT method, and VEGA platform. Finally, the potential environmental risk (phytotoxicity) and human health risks (neurotoxicity, immunotoxicity, genotoxicity, carcinogenicity, developmental toxicity, and endocrine-disrupting toxicity) during PAHs metabolism and transformation were comprehensively evaluated. Among the 473 PAH’s metabolized and transformed products, all PAHs by-products excluding ACY, CHR, and DahA had higher neurotoxicity, 152 PAHs by-products had higher immunotoxicity, and 222 PAHs by-products had higher phytotoxicity than their precursors during biological metabolism and environmental transformation. Based on the TOPKAT model, 152 PAH by-products possessed potential developmental toxicity, and 138 PAH by-products had higher genotoxicity than their precursors. VEGA predicted that 247 kinds of PAH derivatives had carcinogenic activity, and only the natural transformation products of ACY did not have carcinogenicity. In addition to ACY, 15 PAHs produced 123 endocrine-disrupting substances during metabolism and transformation. Finally, the potential environmental and human health risks of PAHs metabolism and transformation products were evaluated using metabolic and transformation pathway probability and degree of toxic risk as indicators. Accordingly, the priority control strategy for PAHs was constructed based on the risk entropy method by screening the priority control pathways. This paper assesses the potential human health and environmental risks of PAHs in different environmental media with the help of models and toxicological modules for the toxicity prediction of PAHs by-products, and thus designs a risk priority control evaluation system for PAHs.
Machine Learning for Prediction of Cognitive Health in Adults Using Sociodemographic, Neighbourhood Environmental, and Lifestyle Factors
Authors: Poudel Govinda R. , Barnett Anthony , Akram Muhammad , Martino Erika , Knibbs Luke D. , Anstey Kaarin J. , Shaw Jonathan E. , Cerin Ester
Published: September 2022

The environment we live in, and our lifestyle within this environment, can shape our cognitive health. We investigated whether sociodemographic, neighbourhood environment, and lifestyle variables can be used to predict cognitive health status in adults. Cross-sectional data from the AusDiab3 study, an Australian cohort study of adults (34–97 years) (n = 4141) was used. Cognitive function was measured using processing speed and memory tests, which were categorized into distinct classes using latent profile analysis. Sociodemographic variables, measures of the built and natural environment estimated using geographic information system data, and physical activity and sedentary behaviours were used as predictors. Machine learning was performed using gradient boosting machine, support vector machine, artificial neural network, and linear models. Sociodemographic variables predicted processing speed (r2 = 0.43) and memory (r2 = 0.20) with good accuracy. Lifestyle factors also accurately predicted processing speed (r2 = 0.29) but weakly predicted memory (r2 = 0.10). Neighbourhood and built environment factors were weak predictors of cognitive function. Sociodemographic (AUC = 0.84) and lifestyle (AUC = 0.78) factors also accurately classified cognitive classes. Sociodemographic and lifestyle variables can predict cognitive function in adults. Machine learning tools are useful for population-level assessment of cognitive health status via readily available and easy-to-collect data.
Exploring the Association between Welfare State and Mental Wellbeing in Europe: Does Age Matter?
Authors: Kalseth Jorid , Donisi Valeria , Miret Marta , Forsman Anna K. , Cresswell-Smith Johanna
Published: September 2022

Previous research reports show mixed results regarding the age gradient in population mental wellbeing, which may be linked to the role that welfare states play. In this study, we investigate whether an age gradient exists in relation to the association between welfare state and mental wellbeing within the adult population in Europe. We combine individual level data from Round 6 of the European Social Survey and country level data on welfare state and use multilevel regression analyses to explore population mental wellbeing. Subjective and psychological wellbeing dimensions were analyzed, and different approaches to measuring welfare state were explored, including a regime typology and composite welfare state measures constructed on the basis of a set of eight individual indicators. We found the age gradient for mental wellbeing to differ between welfare states, with the positive impact of the welfare state increasing with age. A universal and generous welfare state seems to be particularly important for older adults, who are also more likely to be in higher need of transfers and services provided by the welfare state.
A Study on the Effectiveness of IT Application Education for Older Adults by Interaction Method of Humanoid Robots
Authors: Jung Sungwook , Ahn Sung Hee , Ha Jiwoong , Bahn Sangwoo
Published: September 2022

Education using humanoid robots can have a positive impact in many fields, including in medical or physical training. This study investigated the effects of robot interactions with respect to facial expressions, gestures, voices and their combinations on the education of the elderly regarding information and communications technology (ICT) from functional and emotional perspectives. In this study, the robot’s interaction methods were divided into four categories: (1) voice, (2) voice and expression, (3) voice and gesture, and (4) voice and expression and gesture. An experiment involving an educational application with a humanoid robot was conducted with a total of 15 elderly people over the age of 60. The effect of the humanoid robot’s interaction method on education was identified by means of subjective survey evaluation and practice performance data analysis, including error rate, task success rate, and number of retrainings. Through the experiment, functional and emotional aspects of effects were measured. The results showed that performance and perceived effectiveness were not significantly affected by the type of robot interaction, but the degree to which the robot felt like it had emotions, the degree to which the robot felt like a human, and the degree to which the robot was friendly were significantly different according to the interaction type employed by the humanoid robot. The best effect was achieved when voice and gesture were used together during tutoring. Recognizing that ICT education using humanoid robots increases interest and participation in education, such robots are concluded to be a suitable method for performing ICT education. In addition, when designing robotic interactions, the use of the robot’s voice and gestures together is expected to lead to greater anthropomorphism, resulting in a stronger relationship with humanoid robots.
Evaluation of Body Composition in CrossFit® Athletes and the Relation with Their Results in Official Training
Authors: Menargues-Ramírez Rubén , Sospedra Isabel , Holway Francis , Hurtado-Sánchez José Antonio , Martínez-Sanz José Miguel
Published: September 2022

CrossFit® is a high-intensity sport that combines weightlifting, gymnastic skills, and cardiovascular exercises. To find the anthropometric references that define the optimal body composition, it is essential to first find an optimal body composition for one’s physical preparation. The objective of this study is to describe the anthropometric characteristics of 27 Spanish CrossFit® athletes, 19 males aged 39 years old (24–44) and 8 females aged 28 years old (23–40), and how these characteristics influenced their performance. The athletes performed the Fran, Cindy, and Kelly workouts, establishing minimum marks, and the CrossFit Total workout to assess maximum strength. Significant differences were not found in time and repetitions between sexes in skill training, although there was a positive correlation r = 0.876 (p < 0.001) between muscle mass and the Total CrossFit result. We can conclude that the CrossFit® athlete has a low amount of fat mass and a small relative size, which is an advantage when training with bodyweight exercises, and a high muscle mass that provide benefits when strength training. In addition, despite executing movements from a multitude of disciplines, the physical demands for lifting heavy loads resulted in the anthropometric values of athletes being more similar to elite weightlifting athletes than in other sports.
Self-Assessment of Physical Fitness and Health versus Motivational Value of Physical Activity Goals in People Practicing Fitness, Football, Martial Arts and Wheelchair Rugby
Authors: Kotarska Katarzyna , Timoszyk-Tomczak Celina , Nowak Leonard , Sygit Katarzyna , Gąska Izabela , Nowak Maria Alicja
Published: September 2022

The aim of the study was to determine the relationship between self-assessment of physical fitness and health, and the motivational role of physical activity goals in people, depending on their sports discipline. The study included 470 men and 218 women, aged 18–45, from western and southern Poland. The respondents practiced sports recreationally (fitness—F), competitively (football—FB, martial arts—MA), and for rehabilitation and sports purposes (wheelchair rugby—R). The standardized questionnaire for the motivational role of physical activity goals (Inventory of Physical Activity Objectives, IPAO) by Lipowski and Zaleski and the authors’ questionnaire on lifestyle were used. In the statistical analyses, non-parametric statistics were used. Individuals with very high and high self-assessment of their physical fitness and very good self-assessment of health achieved higher scores on the motivational value scale, time management, motivational conflict and multidimensionality of physical activity goals (p < 0.05). Respondents who assessed their health as very good achieved lower results on the perseverance scale, compared to those who assessed their health as good or poor. Self-assessment of physical fitness had a positive, high and moderate correlation with the self-assessment of health in people practicing wheelchair rugby, fitness, football and martial arts (r = 0.61; r = 0.52; r = 0.41; r = 0.40, respectively). Correlations were found between the motivational role and time management in people practicing fitness (r = 0.81), football (r = 0.66) and martial arts (r = 0.45), and multidimensionality of goals in those practicing fitness (r = 0.65) and martial arts (r = 0.42) Wheelchair rugby players scored the highest on all KCAF scales (except for motivational conflict). Self-assessment of physical fitness of wheelchair rugby players and fitness practitioners was negatively correlated with time management (r = −0.68; r = −0.49), multidimensionality of goals (r = −0.51; r = −0.49) and motivational values (r = −0.43; r = −0.43). The demonstrated relationships indicated that there was a need to strengthen the self-esteem and motivation for physical activity, promoting perseverance, the ability to focus on the implementation of one’s goals and prioritizing the goals among people practicing various sports disciplines.
The Impact of the Gain-Loss Frame on College Students’ Willingness to Participate in the Individual Low-Carbon Behavior Rewarding System (ILBRS): The Mediating Role of Environmental Risk Perception
Authors: Qi Ani , Ji Zeyu , Gong Yuanchao , Yang Bo , Sun Yan
Published: September 2022

Since Chinese households account for more than half of the country’s total carbon emissions, efforts focused on consumption will be key to reaching carbon reduction targets. The Individual Low-carbon Behavior Rewarding System (ILBRS) is an emerging mechanism in China that encourages the public to develop a low-carbon lifestyle and it is critical to look for various approaches to enhance the public’s willingness to participate in it. The framing effect has been widely used to study pro-environmental behavior as a low-cost nudge. We used an online questionnaire (N = 320) to investigate how framing information (loss and gain framing) influenced people’s willingness to participate in the ILBRS through the mediation of environmental risk perception. The results indicated that the public’s willingness to participate in the ILBRS under the loss frame was significantly higher than the gain frame. Furthermore, environmental risk perception played a mediating role in the proceedings. Based on our findings, the designers and promoters of ILBRS systems could employ loss-frame information to promote the public’s willingness to participate in the ILBRS and drive more people to live a low-carbon life in the process of mechanism construction, information communication, and operational promotion.
Loss to Follow-Up Risk among HIV Patients on ART in Zimbabwe, 2009–2016: Hierarchical Bayesian Spatio-Temporal Modeling
Authors: Matsena Zingoni Zvifadzo , Chirwa Tobias , Todd Jim , Musenge Eustasius
Published: September 2022

Loss to follow-up (LTFU) is a risk factor for poor outcomes in HIV patients. The spatio-temporal risk of LTFU is useful to identify hotspots and guide policy. Secondary data on adult HIV patients attending a clinic in provinces of Zimbabwe between 2009 and 2016 were used to estimate the LTFU risk in each of the 10 provinces. A hierarchical Bayesian spatio-temporal Poisson regression model was fitted using the Integrated Nested Laplace Approximation (INLA) package with LTFU as counts adjusting for age, gender, WHO clinical stage, tuberculosis coinfection and duration on ART. The structured random effects were modelled using the conditional autoregression technique and the temporal random effects were modelled using first-order random walk Gaussian priors. The overall rate of LTFU was 22.7% (95%CI: 22.6/22.8) with Harare (50.28%) and Bulawayo (31.11%) having the highest rates. A one-year increase in the average number of years on ART reduced the risk of LTFU by 35% (relative risk (RR) = 0.651; 95%CI: 0.592–0.712). In general, the provinces with the highest exceedance LTFU risk were Matabeleland South and Matabeleland North. LTFU is one of the drawbacks of HIV prevention. Interventions targeting high-risk regions in the southern and northern regions of Zimbabwe are a priority. Community-based interventions and programmes which mitigate LTFU risk remain essential in the global HIV prevention campaign.
Arterial Stiffness and HbA1c: Association Mediated by Insulin Resistance in Hispanic Adults
Authors: Martagón Alexandro J. , Fermín-Martínez Carlos A. , Antonio-Villa Neftali Eduardo , Mehta Roopa , Almeda-Valdés Paloma , Vargas-Vázquez Arsenio , Muñoz-Hernández Liliana , Gómez-Velasco Donají V. , Elías-López Daniel , Galán-Ramírez Gabriela A. , del Razo-Olvera Fabiola Mabel , Cruz-Bautista Ivette , González-Arellanes Rogelio , Aguilar-Salinas Carlos A.
Published: September 2022

Arterial stiffness may be associated with glucose metabolism parameters, such as HbA1c, mainly via insulin resistance. We aimed to investigate the association between arterial stiffness and HbA1c and explore the mediator effect of insulin resistance. In this cross-sectional study, arterial stiffness (pulse-wave velocity; PWV), HbA1c, and insulin resistance (METS-IR) were determined in Hispanic adults. In addition to sex and age, various biochemical measurements (glucose, lipid profile, etc.) and adipose tissue (fat mass and visceral fat mass) were considered as potential confounding variables. A multivariate regression analysis shows that HbA1c is associated with PWV, even after adjusting for several confounding variables. Importantly, the results show that insulin resistance mediated 17.9% of the effect of HbA1c over PWV. In conclusion, HbA1c may be a potential resource for predicting arterial stiffness due to the influence of insulin resistance in Hispanic subjects.
Insomnia, Time Perspective, and Personality Traits: A Cross-Sectional Study in a Non-Clinical Population
Authors: Fabbri Marco , Beracci Alessia , Martoni Monica
Published: September 2022

Insomnia disorder is considered a public health problem and additional studies should investigate predisposing and perpetuating factors. This study examined the relationship between Big Five personality traits, time perspective, and insomnia. In a cross-sectional study, 400 participants (227 women; age range 18–74 years) were administered the Big Five Inventory—10 items, the Zimbardo Time Perspective Inventory, and the Insomnia Severity Index (ISI). A measure of chronotype was also included for control purposes. The results show that insomniacs reported lower scores for conscientiousness and extraversion, and for past-positive (PP) and future (F) perspectives, whereas they obtained higher scores for past-negative (PN) perspectives and deviation from a balanced time perspective. The correlations confirmed these findings, but negative correlations between present-hedonistic (PH) perspective and ISI score, and between emotional stability and ISI score, were also found. The mediation analyses showed that F played an indirect role in the relationship between consciousness and ISI score, PN had an indirect effect on the relationship between emotional stability and ISI or between extraversion and insomnia, and PH had an indirect effect on the relationship between extraversion and ISI score. The current outcomes shed light on the mechanisms which serve to mediate the relationship between insomnia and personality traits.
Rehabilitation Outcomes among Frail Older Adults in the United States
Authors: Falvey Jason R. , Ye Joanna Z. , Parker Elizabeth A. , Beamer Brock A. , Addison Odessa
Published: September 2022

Background: Current rehabilitation care paradigms are not well aligned with the needs of frail older adults, but the resultant impact on rehabilitation outcomes is unclear. Understanding how frailty may impact rehabilitation outcomes, and understanding some of the underlying mechanisms, may help inform payment policy changes. Design: This study was a cross-sectional analysis of data from Round 5 of the National Health and Aging and Trends Study (NHATS). We identified older adults who had completed one or more episodes of rehabilitation care and used a validated 5-item NHATS Fried Frailty scale to categorize patients as frail (3/5 or more) or non-frail (≤2/5). We then evaluated the association between frailty status and three key patient outcomes: (1) achievement of rehabilitation goals, (2) functional improvement during rehabilitation episodes, and (3) discontinuation of therapy after exhausting insurance benefits. Lastly, we used multivariable, survey-weighted logistic regression models to estimate adjusted relationships between frailty and rehabilitation outcomes. Results: An estimated 5.6 million survey-weighted older adults in the United States (95% CI 5.1 to 6.0 million) completed an episode of rehabilitation in the past year, an estimated 1,271,290 (95% CI 921,758 to 1,620,822; weighted: 22.8%) of whom were frail. Frail rehabilitation recipients were generally older, had a greater comorbidity burden, and had a higher prevalence of dementia. In adjusted models, frailty was associated with poorer functional outcomes, a lower probability of meeting rehabilitation goals and a greater likelihood of exhausting rehabilitation insurance benefits. Conclusions: Exercise is a well-supported intervention for the management of frailty, but our results suggest that frail older adults are not getting the volume or intensity of rehabilitation treatment needed to maximally improve outcomes—in part due to limited payer coverage of rehabilitation services in the United States.
Does China’s Eco-Province Policy Effectively Reduce the Pollutant Emission Intensities?
Authors: Tang Mingfang , Li Ling , Li Tao , Rong Yuejing , Deng Hongbing
Published: September 2022

Economic development and environmental conservation are two important challenges for China. A series of initiatives including Eco-province (EP) policies have been taken to achieve sustainable development by the Chinese government. Increasing concerns regarding policy implications on sustainable development have increased attention to the topic. However, the research on the relationship between economic development and pollutant (COD, SO2) emission intensities after the implementation of EP policy remains inadequate. We applied a Time-Varying Difference-in-Differences Model by employing Chinese provincial panel data to quantitatively study the policy effect, and further utilized the Mediating Effect Model to analyze the mechanism. The article generates several findings: (1) The EP policy had overall inhibitory effects on both COD and SO2 emission intensities, and it would reduce the emission intensity by 4.99% and 6.77% on average, respectively. However, there was a five year lag in the policy effect. (2) The policy effect was significant in the western and central provinces with high pollutant emission intensities, but not in the eastern provinces. (3) The primary inhibiting mediating effects of Eco-province policy to lower pollutant emission intensity were increased GDP per capita and inventions.
Reliability and Usability Analysis of an Embedded System Capable of Evaluating Balance in Elderly Populations Based on a Modified Wii Balance Board
Authors: Estévez-Pedraza Ángel Gabriel , Hernandez-Laredo Enrique , Millan-Guadarrama María Elena , Martínez-Méndez Rigoberto , Carrillo-Vega María Fernanda , Parra-Rodríguez Lorena
Published: September 2022

This paper analyzes the reliability and usability of a portable electronic instrument that measures balance and balance impairment in older adults. The center of pressure (CoP) metrics are measured with a modified Wii Balance Board (mWBB) platform. In the intra- and inter-rater testing, 16 and 43 volunteers (mean 75.66 and standard deviation (SD) of 7.86 years and 72.61 (SD 7.86) years, respectively) collaborated. Five volunteer raters (5.1 (SD 3.69) years of experience) answered the System Usability Scale (SUS). The most reliable CoP index in the intra-examiner tests was the 95% power frequency in the medial-lateral displacement of the CoP with closed-eyes. It had excellent reliability with an intraclass correlation coefficient ICC = 0.948 (C.I. 0.862–0.982) and a Pearson’s correlation coefficient PCC = 0.966 (p < 0.001). The best index for the inter-rater reliability was the centroidal frequency in the anterior-posterior direction closed-eyes, which had an ICC (2,1) = 0.825. The mWBB also obtained a high usability score. These results support the mWBB as a reliable complementary tool for measuring balance in older adults. Additionally, it does not have the limitations of laboratory-grade systems and clinical screening instruments.
Early-Onset Diabetes in an Infant with a Novel Frameshift Mutation in LRBA
Authors: Galati Alessio , Muciaccia Rosalia , Marucci Antonella , Di Paola Rosa , Menzaghi Claudia , Ortolani Federica , Rutigliano Alessandra , Rotondo Arianna , Fischetto Rita , Piccinno Elvira , Delvecchio Maurizio
Published: September 2022

We describe early-onset diabetes in a 6-month-old patient carrying an LRBA gene mutation. Mutations in this gene cause primary immunodeficiency with autoimmune disorders in infancy. At admission, he was in diabetic ketoacidosis, and treatment with fluid infusion rehydration and then i.v. insulin was required. He was discharged with a hybrid closed-loop system for insulin infusion and prevention of hypoglycemia (Minimed Medtronic 670G). He underwent a next-generation sequencing analysis for monogenic diabetes genes, which showed that he was compound heterozygous for two mutations in the LRBA gene. In the following months, he developed arthritis of hands and feet, chronic diarrhea, and growth failure. He underwent bone marrow transplantation with remission of diarrhea and arthritis, but not of diabetes and growth failure. The blood glucose control has always been at target (last HbA1c 6%) without any severe hypoglycemia. LRBA gene mutations are a very rare cause of autoimmune diabetes. This report describes the clinical course in a very young patient. The hybrid closed-loop system was safe and efficient in the management of blood glucose. This report describes the clinical course of diabetes in a patient with a novel LRBA gene mutation.
An Investigation of the Effects of Brain Fatigue on the Sustained Attention of Intelligent Coal Mine VDT Operators
Authors: Sun Linhui , Guo Zigu , Yuan Xiaofang , Wang Xinping , Su Chang , Jiang Jiali , Li Xun
Published: September 2022

Intelligent mines require much more mental effort from visual display terminal (VDT) operators. Long periods of mental effort can easily result in operator fatigue, which further increases the possibility of operation error. Therefore, research into how brain fatigue affects the sustained attention of VDT operators in intelligent mines is important. The research methods were as follows: (1) Recruit 17 intelligent mine VDT operators as subjects. Select objective physiological indicators, such as reaction time, error rate, task duration, flicker fusion frequency, heart rate, electrodermal activity, and blink frequency, and combine these with the subjective Karolinska Sleepiness Scale to build a comprehensive brain fatigue evaluation system. (2) According to the fatigue-inducing experiment requirements, subjects are required to carry out mathematical operations in accordance with the rules during the presentation time, determine whether the results of the operations fall within the [7, 13] interval, and continue for 120 min to induce brain fatigue. (3) Perform the standard stimulus button response experiment of the sustained attention to response task, before and after brain fatigue, and compare each result. The results show that: (1) When the standard stimulus appeared in the EEG experiment, the amplitude of the early N100 component before and after brain fatigue was significantly different. When the bias stimulus appeared, the average amplitudes of the P200 component and the late positive component, before and after brain fatigue, were significantly different, suggesting that the brain fatigue of VDT workers in coal mines would reduce sustained attention; (2) After the 120 min of the continuous operation task, the subjects showed obvious brain fatigue. The objective brain fatigue was followed by an increase in reaction time, an increase in error rate, a decrease in flicker fusion frequency, an increase in heart rate, an increase in electrodermal current, an increase in the number of blinks, and a larger pupil diameter, and both the subjective and objective data indicated more significant changes in the subjects’ brain fatigue at the 45th and 90th min. The results of the study could provide insight into the reduction in operational efficiency and safety of VDT operators in intelligent mines due to brain fatigue and further enrich the research in the area of brain fatigue in VDT operations.
An Overview of Strategies to Improve Vaccination Compliance before and during the COVID-19 Pandemic
Authors: Charrier Lorena , Garlasco Jacopo , Thomas Robin , Gardois Paolo , Bo Marco , Zotti Carla Maria
Published: September 2022

The debate on vaccination mandate was fuelled over the past two years by the COVID-19 pandemic. This study aimed at overviewing vaccination strategies and corresponding vaccine coverages for childhood vaccinations before the pandemic and for SARS-CoV-2 in high-income countries. A qualitative comparison was also performed between the two contexts: unlike for childhood vaccinations, only one European country (Austria) imposed generalised COVID-19 mandates, most countries preferring targeted mandates for higher-risk categories (Italy, Greece) or workers in key public services (Finland, Australia, New Zealand, UK, Germany). Many countries (Norway, Sweden, Netherlands, Portugal, Spain) confirmed their traditional voluntary vaccination approach also for COVID-19, while others (Slovenia and Hungary), historically relying on compulsory vaccination strategies, surprisingly opted for voluntary SARS-CoV-2 vaccination, with unsatisfactory results in terms of immunisation rates. However, no tangible relationship was generally found between vaccination policies and immunisation coverages: data show that, unlike some countries with mandates, countries where vaccinations are merely recommended could achieve higher coverages, even beyond the recommended 95% threshold. The COVID-19 experience has enriched pre-existent vaccination strategy debates by adding interesting elements concerning attitudes towards vaccines in a novel and unexplored context. Interpreting the available results by considering the different cultural contexts and vaccine hesitancy determinants can help to better understand the complexity of the relationship between policies and achieved coverages.
Working with Goals and Trauma in Youth Mental Health
Authors: Law Duncan
Published: September 2022

There is good evidence of the value of working with goals in youth mental health services and settings. As such, goal-oriented practice is seen as a core component of good mental health interventions. Yet, there is debate among clinicians and academics about whether working with goals is a valid approach with clients who have experienced trauma. In this paper, I will explore the impacts of trauma and argue that working with goals, including the use of tools that facilitate these practices, such as the Goal-Based Outcome (GBO) tool, is as vital when working in trauma-informed interventions, as with any other mode of practice or client group.
Chinese Children with Congenital and Acquired Blindness Represent Concrete Concepts in Vertical Space through Tactile Perception
Authors: Shen Guangyin , Wang Ruiming , Yang Mengru , Xie Jiushu
Published: September 2022

Many studies have tested perceptual symbols in conceptual processing and found that perceptual symbols contain experiences from multisensory channels. However, whether the disability of one sensory channel affects the processing of the perceptual symbols and then affects conceptual processing is still unknown. This line of research would extend the perceptual symbol theory and have implications for language rehabilitation and mental health for people with disabilities. Therefore, the present study filled in this gap and tested whether Chinese children with congenital and acquired blindness have difficulty in recruiting perceptual symbols in the processing of concrete concepts. Experiment 1 used the word-pair-matching paradigm to test whether blind children used vertical space information in understanding concrete word pairs. Experiment 2 used the word-card-pairing paradigm to test the role of tactile experiences in the processing of concrete concepts for blind children. Results found that blind children automatically activated the spatial information of referents in the processing of concepts through the tactile sensory channel even when the visual sensory channel was disabled. This finding supported the compensatory phenomenon of other sensory channels in conceptual representation. In addition, the difference between elementary school blind children and middle school blind children in judging the spatial position of concrete words also indicated the vital influence of perceptual experiences on perceptual symbols in conceptual representation. Interestingly, there were no significant differences between children with congenital or acquired blindness. This might suggest that the compensatory of other sensory channels did not have a sensitive period. This study not only provided new evidence for the perceptual symbol theory but also found that perceptual symbols could be developed by a compensatory mechanism. This compensatory mechanism can be used to develop a rehabilitation program for improving language learning in blind children. Improved language ability in blind children will also improve their mental health problems caused by difficulties in social interaction (e.g., social anxiety).
Associations between Advanced Glycation End Products, Body Composition and Mediterranean Diet Adherence in Kidney Transplant Recipients
Authors: Radić Josipa , Vučković Marijana , Gelemanović Andrea , Kolak Ela , Bučan Nenadić Dora , Begović Mirna , Radić Mislav
Published: September 2022

There is limited evidence on the associations between dietary patterns, body composition, and nonclassical predictors of worse outcomes such as advanced glycation end products (AGE) in kidney transplant recipients (KTRs). The aim of this cross-sectional study was to determine the level of AGE-determined cardiovascular (CV) risk in Dalmatian KTRs and possible associations between AGE, adherence to the Mediterranean diet (MeDi), and nutritional status. Eighty-five (85) KTRs were enrolled in this study. For each study participant, data were collected on the level of AGE, as measured by skin autofluorescence (SAF), Mediterranean Diet Serving Score (MDSS), body mass composition, anthropometric parameters, and clinical and laboratory parameters. Only 11.76% of the participants were adherent to the MeDi. Sixty-nine percent (69%) of KTRs had severe CV risk based on AGE, while 31% of KTRs had mild to moderate CV risk. The results of the LASSO regression analysis showed that age, dialysis type, dialysis vintage, presence of CV and chronic kidney disease, C- reactive protein level, urate level, percentage of muscle mass, and adherence to recommendations for nuts, meat, and sweets were identified as positive predictors of AGE. The negative predictors for AGE were calcium, phosphate, cereal adherence according to the MeDi, and trunk fat mass. These results demonstrate extremely low adherence to the MeDi and high AGE levels related CV risk in Dalmatian KTRs. Lifestyle interventions in terms of CV risk management and adherence to the MeDi of KTRs should be taken into consideration when taking care of this patient population.
The Effectiveness of a Hybrid Exercise Program on the Physical Fitness of Frail Elderly
Authors: Wang Ziyi , Meng Deyu , He Shichun , Guo Hongzhi , Tian Zhibo , Wei Meiqi , Yang Guang , Wang Ziheng
Published: September 2022

Background: Frailty is a serious physical disorder affecting the elderly all over the world. However, the frail elderly have low physical fitness, which limits the effectiveness of current exercise programs. Inspired by this, we attempted to integrate Baduanjin and strength and endurance exercises into an exercise program to improve the physical fitness and alleviate frailty among the elderly. Additionally, to achieve the goals of personalized medicine, machine learning simulations were performed to predict post-intervention frailty. Methods: A total of 171 frail elderly individuals completed the experiment, including a Baduanjin group (BDJ), a strength and endurance training group (SE), and a combination of Baduanjin and strength and endurance training group (BDJSE), which lasted for 24 weeks. Physical fitness was evaluated by 10-meter maximum walk speed (10 m MWS), grip strength, the timed up-and-go test (TUGT), and the 6 min walk test (6 min WT). A one-way analysis of variance (ANOVA), chi-square test, and two-way repeated-measures ANOVA were carried out to analyze the experimental data. In addition, nine machine learning models were utilized to predict the frailty status after the intervention. Results: In 10 m MWS and TUGT, there was a significant interactive influence between group and time. When comparing the BDJ group and the SE group, participants in the BDJSE group demonstrated the maximum gains in 10 m MWS and TUGT after 24 weeks of intervention. The stacking model surpassed other algorithms in performance. The accuracy and precision rates were 75.5% and 77.1%, respectively. Conclusion: The hybrid exercise program that combined Baduanjin with strength and endurance training proved more effective at improving fitness and reversing frailty in elderly individuals. Based on the stacking model, it is possible to predict whether an elderly person will exhibit reversed frailty following an exercise program.
A Review of COVID-19 Response Challenges in Ethiopia
Authors: Abagero Abdulnasir , Ragazzoni Luca , Hubloue Ives , Barone-Adesi Francesco , Lamine Hamdi , Addissie Adamu , Della Corte Francesco , Valente Martina
Published: September 2022

Background: The COVID-19 pandemic has positioned fragile healthcare systems in low-income countries under pressure, leading to critical gaps in service delivery. The pandemic response demands the healthcare system to be resilient and continue provision of healthcare services. This review is aimed at describing the healthcare response challenges during the pandemic in Ethiopia. Methodology: Eligible studies dealing with challenges of the healthcare system in response to the COVID-19 pandemic in Ethiopia were included. The six World Health Organization (WHO) healthcare system building blocks were used to categorize healthcare challenges. PubMed ProQuest, databases were searched, and results were summarized using systematic review synthesis. Results: Financial constraints led to a shortage of mechanical ventilators. Furthermore, the pandemic hindered the capacity to avail full packages of personal protective equipment in health facilities and intensive care capacity. The pandemic also affected the delivery of maternal, child and new-born services, prevention, and treatment of childhood illness, including immunization services. Conclusions: The COVID-19 pandemic posed various challenges to the performance of the healthcare system in Ethiopia. It is recommended that policy makers and stakeholders enhance pandemic preparedness and strengthen response capacity by considering the six WHO healthcare system building blocks.
“We’re Lucky to Have Doctors at All”; A Qualitative Exploration of Australian Farmers’ Barriers and Facilitators to Health-Related Help-Seeking
Authors: Hull Melissa J. , Gunn Kate M. , Smith Ashleigh E. , Jones Martin , Dollman James
Published: September 2022

This study aimed to explore barriers and facilitators that impact on farmers’ help-seeking behaviours for health and mental health concerns. Fifteen semi-structured interviews were conducted with farmers (12 male; age 51.7 ± 12.6 years) from three rural regions in South Australia. Interviews explored demographic and farm-related characteristics, perceptions of individual (and where relevant family) health and mental health concerns and experiences, and perceived barriers of health support-seeking. Thematic analysis was used to identify key themes. Four key themes were identified relating to help-seeking; personal attitudes and beliefs, farm-related barriers, health system barriers and the provision of support from family and friends. Dominant personal attitudes included valuing independence, strength and privacy. Farm related barriers included the ‘farm comes first’ and the fact that ‘farm work is never done’. Health system barriers included issues relating to availability of choice and access, professionals (lack of) understanding of farm life, and time and financial costs of accessing care. Provision of support from family and friends involved informal help and advice, including facilitating access to professional support. Multiple attitudinal, structural, and farm-related issues affect farmers’ help-seeking. Professionals who understand farm work practices and routines are valued by farmers and this is likely to facilitate access to care. Workforce development programs and community programs that involve farmers’ perspectives as consumers and co-designers, using evidence-based strategies, may assist in strengthening these relationships.
Farmland Transfer, Social Security, and Households’ Productive Investment: Based on China’s CFPS Survey
Authors: Ke Shangan , Wu Yueqi , Cui Haiying , Lu Xinhai , Chen Danling
Published: September 2022

The willingness of farmers to transfer land on a big scale will be impacted when the rural social security system is not ideal, which will limit households’ productive investment. This paper investigated the intermediate effects of social security on farmland transfer and productive investment by using zero-inflated models based on 4703 samples across China. Here are the findings: (1) Farmland transfer does not significantly impact productive investment without considering social society. (2) With the improvement in social security, farmland transfer significantly affects fixed investment but is not the same as households’ current investment. (3) Under the social security constraints, there is an inverted U-shaped relationship between farmland transfer and current investment. (4) The partial effect of farmland transfer on fixed investment is significantly positive, and it shows a trend of rising volatility. The government should re-examine the expected effects of the farmland transfer policy and focus on the farmers’ worries about the future. Meanwhile, it is necessary to comprehensively improve the social security system and improve the multi-dimensional survival ability of farmers to give full play to the critical role of farmland transfer in current investment.
Violence in Dating Relationships: Validation of the CADRI Questionnaire in a Young Adult Population
Authors: López-Barranco Pedro José , Jiménez-Ruiz Ismael , Leal-Costa César , Andina-Díaz Elena , López-Alonso Ana I. , Jiménez-Barbero José Antonio
Published: September 2022

Dating violence in the young adult population is reaching alarming levels. However, the instruments used to measure it and their results are still heterogeneous. The main aim of this study was to validate the Conflict in Adolescent Dating Relationships Inventory questionnaire for a young adult Spanish university population aged between 19 and 25 years old, and to describe the types of violence perpetrated and suffered. Material and Methods. Observational, descriptive, cross-sectional study. A validity analysis was carried out through a confirmatory factor analysis. The relative frequencies for each type of violence and the Chi2 test for two dichotomous variables were used to describe the different types of violence perpetrated and suffered. Results: The sample consisted of 976 young adults aged 19–25 years old (M = 21.7 years. SD = 1.8). The confirmatory factor analysis had an adequate structure and a good fit to the model. The types of violence perpetrated and suffered were described according to the sex of the participants, with significant differences found for verbal-emotional violence and physical violence exerted. Conclusions: The confirmatory factor analysis allowed us to consider the application of the questionnaire to be correct for the study population.
Characterization and Degradation Pathways of Microbacterium resistens MZT7, A Novel 17β-Estradiol-Degrading Bacterium
Authors: Hao Peng , Wu Sicheng , Zhang Xiqing , Gou Changlong , Wang Yuqiong , Wang Lixia , Zhu Yanbin , Basang Wangdui , Gao Yunhang
Published: September 2022

Due to the ecotoxicity of 17β-estradiol (E2), residual E2 in the environment poses potential risks to human and animal health and ecosystems. Biodegradation is considered one of the most effective strategies to remove E2 from the environment. Here, a novel, efficient E2-degrading bacterial strain Microbacterium resistens MZT7 was isolated from activated sludge and characterized. The genome of strain MZT7 contained 4,011,347 bp nucleotides with 71.26% G + C content and 3785 coding genes. There was 86.7% transformation efficiency of 10 mg/L E2 by strain MZT7 after incubation for 5 d at optimal temperature (30 °C) and pH (7.0). This strain was highly tolerant to ranges in pH (5.0–11.0), temperature (20–40 °C), and salinity (2–8%). Adding sources of carbon (glucose, maltose, sucrose, or lactose) or nitrogen sources (urea, peptone, or beef extract) promoted the degradation of E2 by strain MZT7. However, when yeast extract was added as a nitrogen source, the degradation efficiency of E2 was inhibited. Metabolites were analyzed by LC-MS and three metabolic pathways of E2 degradation were proposed. Further, the intermediates dehydroepiandrosterone and androsta-1,4-diene-3,17-dione were detected, as well as identification of kshB and fadD3 genes by KEGG, confirming one E2 degradation pathway. This study provided some insights into E2 biodegradation.
Mental Stress in Medical Students during the Pandemic and Their Relation to Digital and Hybrid Semester—Cross-Sectional Data from Three Recruitment Waves in Germany
Authors: Büssing Arndt , Zupanic Michaela , Ehlers Jan P. , Taetz-Harrer Angelika
Published: September 2022

Background: Because of the COVID-19 pandemic, students had to interrupt their regular studies, and universities changed their teaching formats. The aim of this study was to analyze medical students’ stress perception, wellbeing, life and work satisfaction, and cool down reactions, and to compare the survey data of online and hybrid semesters with pre-pandemic education formats in-person. Methods: Cross-sectional surveys at three time points enrolling 1061 medical students (58% women; 24.4 ± 3.4 years); 30.8% from pre-pandemic formats in-person, 22.8% from pandemic online semesters, and 46.1% from pandemic hybrid semesters. Results: Both students’ stress perception and psychological wellbeing decreased during the pandemic semesters. Their satisfaction with the university support was at its lowest during the hybrid semesters. Regression analyses indicated that students’ stress perception can be explained only to some extent by their general dissatisfaction with their medical studies or teaching formats. Conclusions: The lockdowns affected students in more ways than simply their teaching formats. Students require individual support to adjust to difficult situations, and particularly medical students in their preclinical phase compared to students in their clinical phases. These are challenges for the medical education system, which must find ways to be prepared for future times of crisis and insecurity.