bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure Guided Molecular Docking Assisted Alignment Dependent 3DQSAR Study on Steroidal Aromatase Inhibitors (SAIs) as Anti-breast Cancer Agents
Authors: Banjare Laxmi , Verma Sant Kumar , Jain Akhlesh Kumar , Thareja Suresh
Published: October 2018

Background:

In spite of the availability of various treatment approaches including surgery, radiotherapy, and hormonal therapy, the steroidal aromatase inhibitors (SAIs) play a significant role as chemotherapeutic agents for the treatment of estrogen-dependent breast cancer with the benefit of reduced risk of recurrence. However, due to greater toxicity and side effects associated with currently available anti-breast cancer agents, there is emergent requirement to develop target-specific AIs with safer anti-breast cancer profile.

Methods:

It is challenging task to design target-specific and less toxic SAIs, though the molecular modeling tools viz. molecular docking simulations and QSAR have been continuing for more than two decades for the fast and efficient designing of novel, selective, potent and safe molecules against various biological targets to fight the number of dreaded diseases/disorders. In order to design novel and selective SAIs, structure guided molecular docking assisted alignment dependent 3D-QSAR studies was performed on a data set comprises of 22 molecules bearing steroidal scaffold with wide range of aromatase inhibitory activity.

Results:

3D-QSAR model developed using molecular weighted (MW) extent alignment approach showed good statistical quality and predictive ability when compared to model developed using moments of inertia (MI) alignment approach.

Conclusion:

The explored binding interactions and generated pharmacophoric features (steric and electrostatic) of steroidal molecules could be exploited for further design, direct synthesis and development of new potential safer SAIs, that can be effective to reduce the mortality and morbidity associated with breast cancer.
Intelligent Diabetes Detection System based on Tongue Datasets
Authors: Naveed Safia , Geetha Gurunathan
Published: October 2018

Background:

Scanning Electron Microscope (SEM) Camera Imaging shows and helps
analyze hidden organs in the human body. SEM image analysis provides in-depth and critical details of organ abnormalities. Similarly, the human tongue finds use in the detection of organ dysfunction with tongue reflexology.

Objective:

To detect diabetes at an early stage using a non-invasive method of diabetes detection
through tongue images and to utilize the reasonable cost of modality (SEM camera) for capturing
the tongue images instead of the existing and expensive imaging modalities like X-ray, Computed
Tomography, Magnetic Resonance Imaging, Positron Emission Tomography, Single-Photon Emission Computed Tomography etc.

Methods:

The tongue image is captured via SEM camera, it is preprocessed to remove noise and
resize the tongue such that it is suitable for segmentation. Greedy Snake Algorithm (GSA) is used
to segment the tongue image. The texture features of the tongue are analyzed and finally it is classified as diabetic or normal.

Results:

Failure of organs stomach, intestine, liver and pancreas results in change of the color of
the tongue, coating thickness and cracks on the tongue. Changes in pancreas proactive behavior also reflect on tongue coating. The tongue coating texture varies from white or vanilla to yellow also
the tongue coating thickness also increases.

Conclusion:

In this paper, the author proposes to diagnose Diabetes Type2 (DT2) at an early stage
from tongue digital image. The tongue image is acquired and processed with Greedy Snake Algorithm (GSA) to extract edge and texture features.
In silico Molecular Modelling of Selected Natural Ligands and their Binding Features with Estrogen Receptor Alpha
Authors: Maruthanila V.L. , Elancheran R. , Roy Nand Kishor , Bhattacharya Anupam , Kunnumakkara Ajaikumar B. , Kabilan S. , Kotoky Jibon
Published: October 2018

Background:

Breast cancer is one of the most common cancers diagnosed among women. It
is now recognized that two receptors mediate estrogen action and the presence of estrogen receptor alpha
(ERα) correlates with better prognosis and the likelihood of response to hormonal therapy. ERα is
an attractive target for the treatment of breast cancer. Most of the drugs currently used for the breast
cancer treatment have numerous side effects and they are often unsuccessful in removing the tumour
completely. Hence, we focused on natural compounds like flavonoids, polyphenols, etc. which do not
exhibit any high toxic effects against normal cells.

Objectives: To identify the potential natural inhibitors for BCa through an optimised in silico approach.

Methods: Structural modification and molecular docking-based screening approaches were imposed to
identify the novel natural compounds by using Schrödinger (Maestro 9.5). The Qikprop v3.5 was used
for the evaluation of important ADME parameters and its permissible ranges. Cytotoxicity of the
compounds was evaluated by MTT assay against MCF-7 Cell lines.

Results:

From the docking studies, we found that the compounds, Myricetin, Quercetin, Apigenin,
Luteolin and Baicalein showed the highest Glide Scores -10.78, -9.48, -8.92, -8.87 and -8.82 kcal mol-1
respectively. Of these, Luteolin and Baicalein showed the significant IC50 values (25 ± 4.0 and 58.3 ±
4.4 µM, respectively) against MCF-7 cell line. The ADME profiling of the test compounds was evaluated
to find the drug-likeness and pharmacokinetic parameters.

We mainly focused on in silico study to dock the compounds into the human estrogen receptor
ligand binding domain (hERLBD) and compare their predicted binding affinity with known antiestrogens.
Myricetin, Quercetin, Apigenin, Luteolin and Baicalein were identified as the most promising
among all. Of these, Luteolin and Baicalein showed significant anticancer activities against MCF-7 cell
line. These findings may provide basic information for the development of anti-breast cancer agents.
Low-Cost Synthesis of Gold Nanoparticles from Reused Traditional Gold Leaf and its Application for Sensitive and Selective Colorimetric Sensing of Creatinine in Urine
Authors: Mathaweesansurn Arjnarong , Choengchan Nathawut , Khongkaew Putthiporn , Phechkrajang Chutima M.
Published: October 2018

Background:

Gold nanoparticles (Au NPs) are normally prepared using standard gold
(III) trichloride which is much expensive and irritant. This work is aimed at demonstrating simple
and low-cost synthesis of Au NPs from the reused traditional gold leaf which is cost-free and less
toxic.

Methods:

The reused gold leaf was donated by the local temple. It was digested and used as the precursor
for the preparation of the Au NPs by Turkevich method. Poly (vinyl alcohol) (PVA) was employed
as a stabilizer. The as-prepared Au NPs were applied for the colorimetric determination of
creatinine in urine without any sample pretreatment.

Results:

Long-term stability of the gold colloids was achieved for at least 3 months. Morphology and
purity of the as-prepared Au NPs were the same as the ones prepared from standard gold (III) salt
and standard gold foil. Colorimetric response of the Au NPs was linear to the standard creatinine up
to 200 mg L-1. The limit of detection (0.16 mg L-1 or 1.41 μM) was enough sensitive for urinary creatinine
detection in patients with kidney disease. Good recoveries (97-108%) and fast analysis time
(3 min) were achieved. The developed method was successfully validated against the HPLC method.

Conclusion:

Facile and cost-effective synthesis of the Au NPs from the reused traditional gold leaf,
was accomplished. The as-prepared Au NPs were successfully applied for the determination of urinary
creatinine with high sensitivity and selectivity.
Computational Approaches Towards Kinases as Attractive Targets for Anticancer Drug Discovery and Development
Authors: Hameed Rabia , Khan Afsar , Khan Sehroon , Perveen Shagufta
Published: October 2018

Background:

One of the major goals of computational chemists is to determine and develop
the pathways for anticancer drug discovery and development. In recent past, high performance computing
systems elicited the desired results with little or no side effects. The aim of the current review is to evaluate the
role of computational chemistry in ascertaining kinases as attractive targets for anticancer drug discovery and
development.

Methods:

Research related to computational studies in the field of anticancer drug development is reviewed.
Extensive literature on achievements of theorists in this regard has been compiled and presented with special
emphasis on kinases being the attractive anticancer drug targets.

Results:

Different approaches to facilitate anticancer drug discovery include determination of actual targets,
multi-targeted drug discovery, ligand-protein inverse docking, virtual screening of drug like compounds, formation
of di-nuclear analogs of drugs, drug specific nano-carrier design, kinetic and trapping studies in drug design,
multi-target QSAR (Quantitative Structure Activity Relationship) model, targeted co-delivery of anticancer
drug and siRNA, formation of stable inclusion complex, determination of mechanism of drug resistance, and
designing drug like libraries for the prediction of drug-like compounds. Protein kinases have gained enough
popularity as attractive targets for anticancer drugs. These kinases are responsible for uncontrolled and deregulated
differentiation, proliferation, and cell signaling of the malignant cells which result in cancer.

Conclusion:

Interest in developing drugs through computational methods is a growing trend, which saves
equally the cost and time. Kinases are the most popular targets among the other for anticancer drugs which
demand attention. 3D-QSAR modelling, molecular docking, and other computational approaches have not only
identified the target-inhibitor binding interactions for better anticancer drug discovery but are also designing and
predicting new inhibitors, which serve as lead for the synthetic preparation of drugs. In light of computational
studies made so far in this field, the current review highlights the importance of kinases as attractive targets for
anticancer drug discovery and development.
Adipocytokines in Non-functional Adrenal Incidentalomas and Relation with Insulin Resistance Parameters
Authors: Akkus Gamze , Evran Mehtap , Sert Murat , Tetiker Tamer
Published: October 2018

Objective:

Adrenal incidentalomas are diagnosed incidentally during radiological screenings
and require endocrinological investigations for hormonal activity and malignancy. In certain studies, it
has been reported that non-functional incidentalomas can be associated with high adipocytokines levels
affecting the insulin resistance just like the adipose tissue with metabolic syndrome. Here, we studied
serum adipocytokine levels including leptin, resistin, visfatin, omentin 1 and adiponectin in subjects
with non-functional adrenal incidentaloma.

Methods:

Seventy-seven (77) patients (Female 57; Male 20) with non-functional adrenal incidentaloma
(NFAI) were enrolled in the study. All patients’ past medical history, physical examination including
Body Mass Index (BMI) and waist circumference were performed. The patients’ demographic,
radiologic, hormonal and biochemical parameters were recorded. To compare the parameters, a control
group (CG) (n=30) was formed from healthy volunteers. Both groups were matched for age, gender,
waist circumference and BMI. Serum adipocytokines including leptin, resistin, visfatin, omentin 1 and
adiponectin were measured quantitatively by ELISA. Fasting plasma glucose, insulin, sodium, potassium,
cortisol, adrenocorticotropic hormone (ACTH), lipid profiles, and dehidroepiandrostenedion
sulphate (DHEAS) were measured.

Results:

Mean age of the patients was 52.2±10.4 years. BMI and waist circumference of NFAI patients
were 26.2±3.28 kg/m2 and 90.2 ±7.5cm, respectively. The mean age of the control group was
48.0±8.16. BMI and waist circumference values for the control group were 25.3±3.5 kg/m2 and
88.3±9.6 cm, respectively. When both groups were compared for age, gender, BMI and waist circumference
were non-significant (p>0.05). Serum fasting insulin, total cholesterol, LDL, triglyceride levels
of the NFAI group were significantly higher than CG (p<0.05). The insulin resistance index (HOMAIR)
values of the NFAI subjects were found to be higher than CG (2.5±1.37, 1.1±0.3 p=0.00). Resistin
level of NFAI group was also found to be higher than CG [286.6 ng/L vs. 197 ng/L; (P=0,00)], respectively.
Leptin levels of NFAI were significantly higher than CG [441.1 ng/mL vs. 186.5 ng/mL;
(P=0.00)] respectively. Adiponectin levels were significantly reduced in the NFAI group than in the
CG [10.7 mg/L vs. 30.8 mg/L; (P=0.00)]. Comparision of visfatin and omentin levels was nonsignificant.

Conclusion:

In this study on subjects with non-functional adrenal incidentaloma, we found not only
significantly decreased serum adiponectin levels but also increased leptin, resistin levels as well as
dyslipidemia, hypertension and high insulin resistance index. All of which could affect insulin resistance
and cardiovascular risk factors. The underlying mechanisms of these findings are unknown,
hence further studies are needed.
The Inhibitory Effect of Three Essential Oils on Candida rugosa Lipase: In Vitro and In Silico Studies
Authors: Serseg Talia , Benarous Khedidja , Yousfi Mohamed
Published: October 2018

Background:

Essential oils have been used for centuries. EOs are gaining increasing interest because of their acceptance by consumers and their safe status. For the first time, the effect of essential oils on the inhibition of lipases has been investigated in this work.

Objective:

We aimed in this study to investigate in vitro the inhibitory effects of the three essential oils of most used spices: Peppermint (Mentha piperita L.), cinnamon (Cinnamomum zeylanicum L.) and Cloves (Syzygium aromaticum L. Merr. et Perry) against Candida rugose lipase. In silico studies using molecular docking have been achieved to study the inhibition mechanism of major compounds of EO: menthol, carvacrol, eugenol and cinnamylaldehyde toward CRL.

Methods:

The inhibitory effect of three essential oils were determined by candida rugosa enzyme and pNP-L as substrate using spectrophotometry. Autodock vina was used for molecular docking with 50 runs.

Results:

We have found that these essential oils have a strong inhibitory effect with IC50 values 1.09, 1.78 and 1.13 mg/ml compared with Orlistat 0.06 mg/ml. The results show competitive inhibition for the three major compounds Menthol, Carvacrol and Eugenol with uncompetitive inhibition for Cinnamaldehyde. Different repetition ratios of hydrogen bonds and hydrophobic interactions were observed. The saved interactions were with His449, Ser209, Gly123, Gly124 and Phe344 for all molecules.

Conclusion:

These observations support using and considering essential oils and their major compounds as good sources for design new drugs to treat candidiasis and other diseases related to Lipases.
A Two-tier Security Solution for Storing Data Across Public Cloud
Authors: Sharma Kavita , Rafiqui Fatima , Diksha  , Attri Prabhanshu , Yadav Sumit Kumar
Published: October 2018

Background:

Data integrity protection in Cloud Computing becomes very challenging
since the user no longer has the possession of their own data. This makes cloud data storage security
of critical importance. The users can resort to legal action against the cloud provider if the provider
fails to maintain the integrity of the shared data, but it also raises a need to secure users' private data
across the public cloud.

Methods:

In this paper, we propose a novel end-to-end solution to ensure the security of data stored
over a public cloud. It is a two-tier approach where the data is stored in an encrypted format and only
the owner of the data can have access to the original data shared across the cloud. The algorithm
OwnData: Encryption and Decryption is based on AES file encryption, which has the flexibility to
be implemented across different cloud platforms.

Results:

The proposed OwnData model to provide privacy and confidentiality to the user data successfully
secures data in an encrypted format. The users can gain full access control over the accessibility
of their data. The application has been improvised to minimize page load time which enables
it to achieve improvements in scalability. Algorithm and concatenation operators (dot) give minimum
computation load during uploading of data to the cloud platform or downloading the same.

Conclusion:

The algorithm is robust, scalable and secure and It gives the user complete
authorization and control over the data even when data is being stored remotely or in any other
cloud premises.
Critical Review on Food Safety Standard Regulations: A Real Scrutinizing Authority or a Misleading Player for Probiotic Products
Authors: Arora Malika , Kaur Navdeep , Arora Manish , Bansal Parveen
Published: October 2018

Background:

Probiotics is a broad term used for friendly bacteria which are increasingly used in present scenario due to their wide range of health benefits accompanied by low cost and negligible side effects. The status of the probiotics as a component of food is not clear in the health industry. The use of probiotic bacteria is exploited over-the-counter as dietary supplements or in food products such as yogurt, as well as in the pharmaceutical preparations too. These products have witnessed tremendous growth in the market around the globe. For acceptance of probiotics based products with uniform quality, greater safety of patients, with established scientific evidences for holistic therapeutic benefits in the treatment of various ailments, appropriate drafting and implementation of comprehensive regulatory guidelines is the need of the hour. So in this context, already prescribed guidelines in India are reviewed critically.

Conclusion:

This article has been compiled to highlight the variations of food safety standards since 2002 to till date along with the existing ambiguities. Moreover, suggestive consolidations are compiled to take a lead for framing a comprehensive and harmonized guideline to be accepted universally.
Nuevo registro del género Loxogramme (Polypodiaceae) para la flora de Honduras
Authors: Reyes Chavez Johan David , Ramírez Castillo Rosa Maria
Published: October 2018

Antecedentes y Objetivos: Loxogramme mexicana, la única especie mesoamericana del género Loxogramme, fue colectada en el Parque Nacional Montaña de Santa Bárbara (PANAMOSAB), siendo este el primer registro confirmado que se documenta para Honduras.Métodos: Durante inventarios florísticos en el PANAMOSAB se colectó una muestra de Loxogramme mexicana a 1385 m s.n.m. y durante el proceso de identificación de la muestra se encontró un error en la inclusión previa de la especie en el catálogo de pteridofitas del país.Resultados clave: Se presenta el registro del género Loxogramme para Honduras y se amplía la distribución desde México hasta Panamá de la especie L. mexicana, ilustrada con un mapa.Conclusiones: Con el fin de actualizar el catálogo de pteridofitas de Honduras, es necesario revisar las especies citadas en la literatura y ejecutar investigaciones de línea base para conocer la riqueza del grupo en el país.
Modelización y mapeo estacional del índice de área foliar en un bosque tropical seco usando imágenes de satélite de alta resolución
Authors: Nafarrate-Hecht Ana Cristina , Dupuy-Rada Juan Manuel , George-Chacon Stephanie P. , Hernández-Stefanoni José Luis
Published: October 2018

El índice de área foliar (IAF) proporciona información acerca de la cantidad de superficie fotosintética que existe en relación con la superficie total del ecosistema y se relaciona con procesos vitales como la fotosíntesis, la respiración y la productividad. Por lo tanto, es importante contar con información sobre la distribución espacial del IAF a escala de paisaje. El método indirecto más utilizado para la estimación del IAF se basa en imágenes de satélite y consiste en asociarlo con características espectrales e índices de vegetación. Sin embargo, estos índices tienen una fuerte limitación debido a problemas de saturación, lo cual restringe la posibilidad de generar mapas precisos de IAF, particularmente en bosques con altos niveles de biomasa. En el presente trabajo se obtuvieron modelos para mapear el IAF en un bosque tropical seco de Yucatán durante las estaciones de lluvia y estiaje a partir de imágenes de alta resolución, utilizando un procedimiento de regresión combinado con kriging. Este procedimiento integra la relación del IAF, tanto con datos espectrales y de textura de las imágenes, como con la dependencia espacial de los residuales. Se obtuvieron valores de IAF por medio de fotografías hemisféricas con una precisión aceptable y valores medios significativamente diferentes entre la temporada de lluvias (3.37) y la de estiaje (2.49). Los valores de R2aj de los modelos de regresión múltiple fueron de 0.58 y 0.63 para la temporada de lluvias y estiaje, respectivamente. En general, los resultados demuestran que, al utilizar el análisis de textura, se pueden generar modelos aceptables para la estimación del IAF en bosques tropicales secos con altos niveles de biomasa.
Real-world efficacy: intravenous palonosetron three-drug regimen for chemotherapy-induced nausea and vomiting with highly emetogenic chemotherapy
Authors: Schwartzberg Lee S , McLaughlin Trent , Geller Robert B , Gabrail Nashat Y , Marks Stanley M
Published: October 2018

Aim:
Real-world palonosetron effectiveness was evaluated in an antiemetic regimen with highly emetogenic chemotherapy (HEC).
Patients & methods:
In this Phase IV, prospective, multicenter observational study, HEC-treated cancer patients received palonosetron, a neurokinin 1 receptor antagonist, and dexamethasone. Primary objective was to assess complete response (CR) for acute (≤24 h), delayed and overall (≤120 h) chemotherapy-induced nausea and vomiting.
Results:
Of 159 patients, 65.4% had breast cancer, 64.8% received anthracycline (doxorubicin)-plus-cyclophosphamide-containing chemotherapy; 155 completed one HEC cycle. CR was 60.0% acute, 39.4% delayed and 34.8% overall, and then increased (all phases) in 69 patients completing four HEC cycles. Anthracycline (doxorubicin) plus cyclophosphamide-receiving patients had especially low CR.
Conclusion:
Even within a recommended three-drug antiemetic regimen, palonosetron may provide suboptimal chemotherapy-induced nausea and vomiting control with HEC in real-world settings.
Una herramienta informática para la coordinación de las prácticas de laboratorio del Grado en Química
Authors: García Clara , Millán Judith , Campos Pedro J. , Rubio Angel L.
Published: October 2018

En este artículo se presenta un gestor documental de las sesiones de laboratorio del Grado en Química de la Universidad de La Rioja, que contiene la información referente al título y resumen de las sesiones de laboratorio realizadas en el grado. Las sesiones están clasificadas en el gestor en módulos, materias, cursos, semestres y asignaturas, junto con sus palabras clave asociadas. El gestor desarrollado cuenta con una jerarquía de tipos de usuarios en función de su rol en la aplicación y permite realizar consultas y búsquedas de sesiones de laboratorio aplicando diversos filtros. Una vez completado el diseño del mismo, se ha puesto a disposición del profesorado del grado para que puedan aplicarlo en la implementación o modificación de sesiones de laboratorio con la información de las prácticas ya realizadas, lo que permitirá aumentar la coordinación horizontal y vertical de las prácticas de laboratorio programadas en todo el grado. No obstante, la utilidad del gestor implica su actualización en cada curso académico, incluyendo las novedades propias de cada curso (actualización del profesorado, modificación de sesiones de prácticas por mejora o eliminación, inclusión de nuevas prácticas, etc.), por lo que es una herramienta en constante evolución.
“La previa”: una estrategia de aprendizaje en las prácticas de química
Authors: Prat María Rosa , Ballesteros Cecilia , M. Lescano Gabriela
Published: October 2018

En este artículo se presenta una estrategia didáctica utilizada con el objetivo de hacer del laboratorio químico un espacio de enseñanza-aprendizaje promoviendo la participación activa del estudiante en el diseño experimental.

La misma surge a partir de la reflexión de la propia práctica docente buscando mejorar el equilibrio entre lo sistemático y lo desordenado durante el proceso de construcción de nuevos saberes que se da en el laboratorio.
Previo a la realización del Trabajo Práctico (TP) se propone al alumno la resolución de una situación problemática, generalmente de la vida cotidiana y de respuesta abierta, con el objetivo de fomentar la integración de saberes previos y habilidades propias con los contenidos ofrecidos en otros espacios de enseñanza-aprendizaje dentro de la asignatura (seminarios, apuntes, clases de problemas, discusiones grupales). De esta manera, la discusión que se desarrolla en el momento inicial del TP encontrará a cada estudiante más involucrado en el diálogo y con herramientas para enriquecer el intercambio de ideas a fin de construir un protocolo de trabajo.
Investigating the Influence of Dynamic Characteristics of a Moving Carrier on the Accuracy of Shooting
Authors: Korolev S A , Rusyak I G , Tenenev V A , Vagin A V , Beloborodov M N
Published: October 2018

В работе приводится математическая модель механической системы подвижного носителя, позволяющая учесть движение и вибрации вертолета, а также взаимное влияние системы «вертолет - вооружение». Механическая система «вертолет - вооружение» представляется в виде совокупности материальных точек: жесткая оболочка (корпус вертолета), подвижные материальные точки, приводящие к вибрациям (винты и турбины) и покидающие систему (снаряды и ракеты). Система уравнений движения в подвижной системе координат записывается в векторной форме относительно суммарного импульса и кинетического момента механической системы. Ориентация подвижной системы координат определяется с помощью направляющих косинусов. Для источников вибраций (винты и турбины) амплитуда и частота колебаний определяются на основе экспериментальных данных. Для материальных точек, соответствующих боеприпасам, характеристики движения определяются законами движения снаряда в стволе (ракеты по направляющей пусковой установки). Система дифференциальных уравнений движения решается численно методом Рунге - Кутта - Вернера 6-го порядка точности с контролем погрешности интегрирования. По результатам моделирования механической системы подвижного носителя рассчитываются начальные условия стрельбы в моменты выстрелов. Траектория движения снарядов и ракет рассчитывается на основе разработанной методики решения задачи внешней баллистики при стрельбе с подвижного носителя. Представлены результаты исследования разброса снарядов и ракет при стрельбе очередью в зависимости от параметров движения подвижного носителя и режима стрельбы.
Statement of the problem of intellectualization of computer-aided system of arbitration manager work based on results of his functionality analysis
Authors: Malina O V , Shaekhov I I
Published: October 2018

Разработка системы автоматизации деятельности арбитражного управляющего является актуальной научно-практической задачей в силу сложности, многофакторности и серьезности задач, решаемых данным специалистом. Особенность деятельности арбитражного управляющего характеризуется, во-первых, большим количеством функций, анализ которых частично приводится в статье, во-вторых, большим количеством нормативных актов, строгость соблюдения которых регламентируется законодательством, в-третьих, высокими требованиями к уровню профессионализма как в области экономики, так и в области права. Существующие системы, анализ которых приведен в статье, позволяют автоматизировать рутинные операции: формирование стандартного перечня необходимых мероприятий с предложениями по их выполнению, подготовку документов, необходимых при реализации любой из процедур банкротства, и т. д. Указанный набор возможностей позволяет серьезно облегчить работу арбитражного управляющего, однако процедуры реального планирования и контроля деятельности осуществляются специалистом в «ручном» режиме. Задача интеллектуализации указанной системы возникла в связи с потребностью автоматизировать интеллектуальную деятельность управляющего, в результате чего отслеживание текущего состояния работ и планирование дальнейшей деятельности с учетом текущего состояния выполняла бы сама автоматизированная система. В идеале это означает, что система должна работать в режиме реального времени, и в каждый момент предлагать пользователю работы, требующие выполнения, максимально сопровождая их информационно. Система также должна отслеживать возможность выполнения работ, например, соответствие временным ограничениям, «накладки», отсутствие или несвоевременное поступление необходимых внешних данных и др. Таким образом, фактически изменится функция пользователя относительно процесса деятельности: из лица, проектирующего процесс, он превратиться в лицо, принимающее решение. Для решения указанной задачи следует построить три взаимосвязанные модели: модель деятельности арбитражного управляющего (определить элементы (модули) этой деятельности); модель процесса арбитражного управления (правила построения процесса исходя из существующей модели деятельности и внешних ограничений); модель системы, позволяющей автоматизировать указанный выше процесс. Предлагаемый подход требует изменения взаимодействия системы и пользователя: интерфейс системы перестает быть «универсальным», он становится «актуальным».
Numerical Analysis of Influence of Mechanical Processing Conditions on Stress-Deformed State of Large-Size Thin-Wall Complex Parts
Authors: Kugultinov S D , Shchenyatskii A V , Zhilyaev A S
Published: October 2018

Многие предприятия приборостроительной, машиностроительной, авиакосмической отрасли сталкиваются с трудностями механической обработки крупногабаритных тонкостенных деталей сложной формы из алюминиевых сплавов, отвечающих за работоспособность всего изделия. К рассматриваемой группе деталей предъявляются повышенные требования по точности и качеству изготовления, к ним относятся несущие элементы конструкции летательных аппаратов, корпуса, волноводы, радиаторы. Зачастую допуск формы на поверхностях данных деталей не превышают 0,01 мм при площади поверхности 1-2 м2. Для обеспечения выпуска качественной продукции без увеличения производственного цикла и затрат на отработку технологии необходимо применение численного инженерного анализа для моделирования сложных технологических процессов. Статья содержит обоснование актуальности исследования взаимосвязи режимов механической обработки, схемы и усилия закрепления с технологическими остаточными напряжениями и деформациями детали. Представлены результаты анализа напряженно-деформированного состояния (НДС), возникающего в процессе фрезерования под воздействием силы и температуры резания, методом конечных элементов (МКЭ). На основе расчетов методом МКЭ показано, что в процессе фрезерования под действием силы резания в детали формируются сжимающие остаточные напряжения, приводящие к короблению поверхностей деталей. Разработана имитационная модель механического воздействия концевой фрезы на обрабатываемую деталь. Полученные результаты в дальнейшем планируется применить для формирования управляющих воздействий на параметры технологического процесса с целью повышения качества обработки и минимизации цикла производства деталей.
Finite-Element Modeling of Transients in Capacitor with Distributed Parameters
Authors: Sibgatullin B I , Barsukov V K
Published: October 2018

Танталовые конденсаторы имеют большую удельную емкость благодаря пористой структуре анода. Эта особенность их строения приводит к тому, что при анализе на высоких частотах или расчете переходных процессов с малым значением постоянной времени танталовый конденсатор нельзя рассматривать как элемент с сосредоточенными параметрами. При этом лестничная схема замещения дает более точные результаты расчетов в частотной и временной областях. Можно предположить, что в процессе заряда конденсатора с распределенными параметрами напряженность электрического поля и плотность тока распределены неравномерно по структуре конденсатора, что может приводить к неравномерной нагрузке на различные области конденсатора. Для проверки этой гипотезы был проведен конечно-элементный анализ процесса заряда структуры конденсатора с распределенными параметрами, который показал, что области конденсатора, расположенные вблизи катодного вывода, подвергаются воздействию зарядных токов большей амплитуды. Возможны ситуации, при которых в этих областях наблюдаются колебательные переходные процессы при общем апериодическом процессе заряда конденсатора, что приводит к возникновению перенапряжений в этих областях. Степень влияния распределенности параметров конденсатора на характер переходных процессов снижается с ростом проводимости материала катода.
A descoberta do território e outras premissas do desenvolvimento territorial
Authors: Saquet Marcos Aurelio
Published: October 2018

Neste texto, socializamos algumas reflexões feitas a partir de três projetos de cooperação que efetivamos com camponeses agroecológicos e com moradores simples e humildes da periferia urbana da cidade Francisco Beltrão (Paraná), evidenciando a abordagem territorial adotada na pesquisa e nas ações participativas, a descoberta do território como componente fundamental do desenvolvimento de base local, cultural e ecológica, bem como a centralidade da criação e/ou qualificação da consciência de classe e de lugar na ativação de territorialidades voltadas para a cooperação, a solidariedade, a luta e a resistência política diante das forças hegemônicas do capital e do Estado burguês.
Política urbana e participação: Presença e voz no Conselho da Cidade de Curitiba
Authors: Braga Andréa Luiza Curralinho , Pessali Huáscar Fialho
Published: October 2018

A política urbana em Curitiba tem o Conselho Municipal da Cidade de Curitiba (Concitiba) como instância participativa permanente. Como salienta Graham Smith (2009), o desenho institucional de uma instância dessa natureza é capaz de influenciar a sua capacidade de produzir bens democráticos. Um desses bens é a inclusão, que pode ser dimensionada por meio de dois vetores: presença e voz. Este texto aborda o desenho institucional do Concitiba e dimensiona o quanto produz de inclusão através da presença e da voz ao longo de suas duas primeiras gestões (2008 a 2013). Com relação à presença, encontramos a predominância regimental e efetiva de dois grupos, o setor público e o setor produtivo. Com relação à voz, notamos amplo provimento de espaço para os grupos representados. Há grande preocupação com a organização interna do conselho, mas crescem ao longo do tempo manifestações de posições divergentes e projetos conflitantes nos temas de política urbana em si.
Imposto sobre Propriedade: uma reflexão crítica do caso do Município de São Paulo e da Cidade de Nova Iorque
Authors: Borges Luís Maurício Martins
Published: October 2018

A questão central da investigação está em perceber as diferentes formas, relações e sistemas de imposto sobre a propriedade da terra urbana e a repercussão na organização política, econômica e social do Município de São Paulo (MSP) e da Cidade de Nova Iorque (NYC) entre 2000 e 2015. A partir das especificidades da execução da política fiscal, observam-se quais são os espaços, organizações, coalizões e interesses advindos das configurações da dinâmica política e imobiliária. Dessa forma, consideramos algumas instituições, estratégias e movimentos interessados na produção e uso da propriedade imobiliária (moradia, direito à renda e valorização da riqueza), no bojo da política pública, fiscal e urbana das cidades. A investigação reflete sobre alguns dos determinantes da diferença fiscal do tributo sobre a propriedade da terra, no que diz respeito aos padrões de relação entre os agentes e instituições que estabelecem específicas dinâmicas de produção, uso e apropriação do espaço social.
Timing of transjugular intrahepatic portosystemic stent-shunt in Budd–Chiari syndrome: A UK hepatologist's perspective
Authors: Khan Faisal , Mehrzad Homoyon , Tripathi Dhiraj
Published: October 2018

Budd–Chiari syndrome (BCS) is a rare but fatal disease caused by the obstruction in hepatic venous outflow tract (usually by thrombosis) and is further classified into two subtypes depending on the level of obstruction. Patients with BCS often have a combination of prothrombotic risk factors. Clinical presentation is diverse. Stepwise management strategy has been suggested with excellent 5-year survival rate. It includes anticoagulation, treatment of identified prothrombotic risk factor, percutaneous recanalization, and transjugular intrahepatic portosystemic shunt (TIPS) to reestablish hepatic venous outflow and liver transplantation in unresponsive patients. Owing to the rarity of BCS, there are no randomized controlled trials (RCTs) precisely identifying the timing for TIPS. TIPS should be considered in patients with refractory ascites, variceal bleed, and fulminant liver failure. Liver replacement is indicated in patients with progressive liver failure and in those in whom TIPS is not technically possible. The long-term outcome is usually influenced by the underlying hematologic condition and the development of hepatocellular carcinoma. This review focuses on the timing and the long-term efficacy of TIPS in patients with BCS.
Advances in Stroke Prevention
Authors: David Spence J.
Published: October 2018

There have been recent advances in stroke prevention in nutrition, blood pressure control, antiplatelet therapy, anticoagulation, identification of high-risk asymptomatic carotid stenosis, and percutaneous closure of patent foramen ovale. There is evidence that the Mediterranean diet significantly reduces the risk of stroke and that B vitamins lower homocysteine, thus preventing stroke. The benefit of B vitamins to lower homocysteine was masked by harm from cyanocobalamin among study participants with impaired renal function; we should be using methylcobalamin instead of cyanocobalamin. Blood pressure control can be markedly improved by individualized therapy based on phenotyping by plasma renin and aldosterone. Loss of function mutations of CYP2D19 impair activation of clopidogrel and limits its efficacy; ticagrelor can avoid this problem. New oral anticoagulants that are not significantly more likely than aspirin to cause severe bleeding, and prolonged monitoring for atrial fibrillation (AF), have revolutionized the prevention of cardioembolic stroke. Most patients (~90%) with asymptomatic carotid stenosis are better treated with intensive medical therapy; the few that could benefit from stenting or endarterectomy can be identified by a number of approaches, the best validated of which is transcranial Doppler (TCD) embolus detection. Percutaneous closure of patent foramen ovale has been shown to be efficacious but should only be implemented in selected patients; they can be identified by clinical clues to paradoxical embolism and by TCD estimation of shunt grade. “Treating arteries instead of treating risk factors,” and recent findings related to the intestinal microbiome and atherosclerosis point the way to promising advances in future.
Citrate: How to get started and what, when, and how to monitor?
Authors: Honore Patrick M. , Bels David De , Preseau Thierry , Redant Sebastien , Spapen Herbert D.
Published: October 2018

In most of the case, regional citrate anticoagulation is using diluted citrate around 1% depending on the types used in clinical practice. Diluted citrate is much more safer when compared to highly concentrated citrate around 4% or even more. In clinical practice, trisodium citrate is used in high concentration (around 30%) as a bactericidal agent with anticoagulant properties for locking deep venous catheters used in hemodialysis (HD; close to 25–30% of citrate). In this review article, buffer and anticoagulant potential of citrate are discussed during renal replacement therapy in critically ill patients with particular focus on the practical approach at the bedside.
Implementasi Fuzzy Logic Pada Robot Line Follower
Authors: Wajiansyah Agusma , Supriadi Supriadi , Nur Syarifah , Wicaksono P Arief Bramanto
Published: October 2018

Pada penelitian ini, akan diterapkan konsep fuzzy logic sebagai kendali cerdas pada robot line follower. Aturan pada fuzzy logic menggunakan metode mamdani. Sebagai input kendali digunakan 2 nilai hasil pembacaan sensor garis yang merupakan data biner 6-bit, yaitu pembacaan pada saat sampling ke-(k) dan pembacaan pada saat sampling ke-(k-1). Hasil pembacaan sensor diberi bobot dengan range nilai dari 0 s/d 255 yang merupakan semesta pembicaraan dari fuzzy set input ini. Setiap fuzzy set input menggunakan 5 membershif function, dan rule base yang digunakan sebanyak 25. Pada fuzzy set output digunakan 5 membership function dengan semesta pembicaraan adalah -127 s/d +127. output fuzzy merupakan bilangan crips tunggal yang didapat dengan menggunakan metode COG (Center of Gravity). Nilai crips output ini digunakan sebagai nilai deviasi untuk mengatur nilai PWM pada motor penggerak roda kiri dan kanan dari robot line follower. Pengujian fungsi kendali menggunakan metode matematis dan simulasi berbasis Simulink. Dari hasil yang didapat menjelaskan bahwa robot dapat bergerak sesuai dengan desain rule base yang digunakan.  Abstract In this research, the fuzzy logic concept will be applied as intelligent control on line-follower robot. The rules on fuzzy logic use the Mamdani method. As control inputs, used 2 values of line sensor readings are in the form of 6-bit binary data. the input is the sensor reading at the time of the kth sampling and the reading at the k-sampling moment. The sensor readings are weighted with a range of values from 0 s / d 255 which is the universe of speech from the fuzzy set of these inputs. Each fuzzy set of inputs uses 5 membership function, and the base rule used is 25. In fuzzy set output used 5 membership functions with the universe of talk is -127 s / d +127. the fuzzy output is a single crips number obtained by using the COG (Center of Gravity) method. This output crips value is used as the deviation value to set the PWM value on the left and right wheel drive motor of the line follower robot. Tests of control functions using mathematical methods and Simulink based simulations. From the results obtained to explain that the robot can move in accordance with the design of the base rule used
Implementasi Simple Additive Weighting dan Weighted Product pada Sistem Pendukung Keputusan untuk Rekomendasi Penerima Beras Sejahtera
Authors: Berlilana Berlilana , Prayoga Fandhi Dhuga , Utomo Fandy Setyo
Published: October 2018

Salah satu upaya pemerintah untuk mengatasi masalah kemiskinan di Indonesia yaitu membuat program beras sejahtera (RASTRA). RASTRA merupakan program dari pemerintah berupa bantuan beras bersubsidi untuk membantu masyarakat yang berpenghasilan rendah. Permasalahan yang terjadi yakni banyaknya kriteria penilaian yang digunakan dalam pedoman RASTRA dan penduduk miskin di suatu area/wilayah seringkali menyulitkan proses penentuan Keluarga Penerima Manfaat yang berhak menerima RASTRA pada Musyawarah desa/kecamatan. Tujuan penelitian ini adalah merancang dan mengembangkan sistem penunjang keputusan menggunakan model matematika Simple Additive Weighting (SAW) dan Weighted Product (WP) untuk memberikan rekomendasi penerima RASTRA. Terdapat empat tahapan penelitian yang digunakan untuk mencapai tujuan penelitian, yaitu analisis kebutuhan perangkat lunak, desain perangkat lunak, pengembangan, dan pengujian perangkat lunak. Berdasarkan hasil pengujian, hasil perhitungan nilai preferensi SAW memiliki performa yang lebih baik daripada WP karena SAW mampu meminimalisir nilai preferensi alternatif yang sama. Hal ini tampak dari perankingan alternatif berdasarkan hasil perhitungan SAW sejumlah 13 peringkat, dan WP sejumlah 10 peringkat. AbstractOne of the government's efforts to overcome the poverty problem in Indonesia is to make the program "Beras Sejahtera" (RASTRA). RASTRA is a government program of subsidised rice to help low-income communities. The problems which occur are the number of assessment criteria used in the RASTRA guidelines and the poor in an area/region often complicate the process of determining the Beneficiary Family who are eligible to receive RASTRA at the village/sub-district deliberation. The purpose of this research is to design and develop decision support system using Simple Additive Weighting (SAW) and Weighted Product (WP) mathematical model to give the recommendation of RASTRA recipient. There are four research stages to achieve the research objectives, namely software requirements analysis, software design, development, and software testing. Based on the test results, the calculation of SAW preference values has better performance than WP because SAW can minimise the value of the same alternative preferences. This can be seen from the alternative ranking based on the calculation of SAW of 13 ranks, and WP 10 rank number.
Perbandingan Kinerja Metode Naive Bayes dan K-Nearest Neighbor untuk Klasifikasi Artikel Berbahasa indonesia
Authors: Devita Riri Nada , Herwanto Heru Wahyu , Wibawa Aji Prasetya
Published: October 2018

Kecocokan isi artikel dengan sebuah tema jurnal menjadi faktor utama diterima tidaknya sebuah artikel. Tetapi masih banyak mahasiswa yang bingung untuk menentukan jurnal yang sesuai dengan artikel yang dimilikinya. Untuk itu diperlukannya sebuah metode klasifikasi dokumen yang dapat mengelompokkan artikel secara otomatis dan akurat. Terdapat banyak metode klasifikasi yang dapat digunakan. Metode yang digunakan dalam penelitian ini adalah Naive Bayes dan sebagai baseline digunakan metode K-Nearest Neighbor. Metode Naive Bayes dipilih karena dapat menghasilkan akurasi yang maksimal dengan data latih yang sedikit. Sedangkan metode K-Nearest Neighbor dipilih karena metode tersebut tangguh terhadap data noise. Kinerja dari kedua metode tersebut akan dibandingkan, sehingga dapat diketahui metode mana yang lebih baik dalam melakukan klasifikasi dokumen. Hasil yang didapatkan menunjukkan metode Naive Bayes memiliki kinerja yang lebih baik dengan tingkat akurasi 70%, sedangkan metode K-Nearest Neighbor memiliki tingkat akurasi yang cukup rendah yaitu 40%. AbstractOne way to be accepted in a journal conference and get the publication is to create an article with perfect suitability content of the journal. Matching the content of the article with a journal theme is the main factor for acceptability an article. But there are still many students who are confused to choose the journal in accordance with the articles it has. So we need a method to classification article documents category automatically and accurately group articles. There are many classification methods that can be used. The method used in this study is Naive Bayes and as a baseline the K-Nearest Neighbor method. Naive Bayes method is chosen because it can produce maximum accuracy with little training data. While K-Nearest Neighbor method was chosen because the method is robust to data noise. The performance of the two methods will be compared, so we can be known which method is better in classifying the document. The results show that the Naive Bayes method performs is more accurate with 70% accuracy and K-Nearest Neighbors method has a fairly low accuracy of 40% on classification test.