bluuebunny/crossref_metadata_2025 huggingface dataset:
Biological characteristics of adipose tissue‐derived stem cells labeled with amine‐surface‐modified superparamagnetic iron oxide nanoparticles
Authors: Wang Nan , Zhao Jing‐Yuan , Guan Xin , Dong Yue , Liu Yang , Zhou Xiang , Wu Ren'an , Du Yue , Zhao Liang , Zou Wei , Han Chao , Song Lin , Sun Bo , Liu Yan , Liu Jing
Published: March 2015

Cell labeling and tracking are becoming increasingly important areas within the field of stem cell transplantation. The ability to track the migration and distribution of implanted cells is critical to understanding the beneficial effects and mechanisms of stem cell therapy. The present study investigated the effects of amine‐surface‐modified superparamagnetic iron oxide (SPIO) nanoparticles on the biological properties of human adipose tissue‐derived stem cells (hADSCs). Monodisperse hydrophobic magnetite (Fe3O4) nanoparticles were prepared using silicon and surface‐modified with amine coating. Cell viability, proliferation, differentiation potential, and surface marker expression were evaluated. The magnetic particles (10–18 nm) displayed high labeling efficiency and stability in hADSCs. SPIO‐labeled cells produced a hypointense signal and were effectively visualized by MRI for up to 21 days. The results of MTT proliferation assays and flow cytometry analysis demonstrated that SPIOs were biocompatible, viz. the labeling process did not cause cell death or apoptosis and had no side effects on cell proliferation. In vivo experiments showed that the magnetic particles did not affect liver and kidney function. The successful and stable labeling of hADSCs combined with efficient magnetic tropism demonstrates that SPIOs are promising candidates for hADSC tracking in hADSC‐based cell therapy applications.
Identification of LncRNAs/mRNAs related to endometrium function regulated by Homeobox A10 in Ishikawa cells
Authors: Lin Ruiyi , Zhao Changzhi , Jing Lu , Zhao Shuhong
Published: March 2015

As a well‐known transcription factor, Homeobox A10 (HOXA10) regulates a large number of downstream target genes, leading to the proper function development of endometrium for embryo implantation. The change of HOXA10 gene expression level can alter the expressions of many other genes, including coding and noncoding transcripts. In our study, mRNA and LncRNA expression profiles screening was performed by microarray when the HOXA10 gene expression level increased in Ishikawa cells. A total of 907 mRNAs and 1,026 LncRNAs were identified as differentially expressed transcripts (Fold Change ≥2, P‐value <0.05, and Q‐value <0.05) between HOXA10 overexpressed and control Ishikawa cells. Further analysis identified that these mRNAs participated in various biological processes, such as blood vessel development, cell adhesion, cell cycle, etc. Also, 14 enhancer‐like LncRNAs and 108 LincRNAs with their nearby mRNAs were identified as coregulated transcripts. Our results showed that the mRNA and LncRNA expression profiles differed significantly between the two groups and provided useful information for further studying the molecular mechanisms of HOXA10 in endometrium.
Multiscale Discrete Supercomputing – A Game Changer for Process Simulation?
Authors: Ge Wei , Lu Liqiang , Liu Shiwen , Xu Ji , Chen Feiguo , Li Jinghai
Published: March 2015

To address the challenge of virtual process engineering (VPE), a systematic co‐design of the physical model, numerical software, and computer hardware was conducted, eventually leading to the so‐called EMMS Paradigm, which can greatly accelerate simulation speed while reducing its cost. Following this paradigm, a multiscale software framework was developed, coupling continuum and coarse‐grained discrete simulations and a multiscale hardware architecture with different parallelization schemes, which have drawn the dream of VPE a substantial step closer: High‐resolution interactive simulation of pilot‐scale reactors or direct numerical simulation of microreactors, both at quasi‐real time speed for the multiphase hydrodynamics, are now possible on the upgraded Mole‐8.5 supercomputing system. The spectrum of multiscale methods available or to be developed for different purposes in VPE, and the corresponding software and hardware co‐designing from more fundamental levels, are discussed also.
Unprecedented Trinuclear AgI Complex with 2,4,6‐Tris(2‐pyrimidyl)‐1,3,5‐triazine as an Efficient Catalyst for the Aziridination of Olefins
Authors: Safin Damir A. , Pialat Amélie , Korobkov Ilia , Murugesu Muralee
Published: March 2015

An unprecedented trinuclear heteroleptic AgI complex was isolated using a stable multidentate 2,4,6‐tris(2‐pyrimidyl)‐1,3,5‐triazine (TPymT) ligand. The obtained compound is an efficient catalyst for the direct aziridination of terminal olefins.
Homo‐ and Heteronuclear Compounds with a Symmetrical Bis‐hydrazone Ligand: Synthesis, Structural Studies, and Luminescent Properties
Authors: Rodríguez‐Hermida Sabina , Lago Ana B. , Carballo Rosa , Fabelo Oscar , Vázquez‐López Ezequiel M.
Published: March 2015

Nine new coordination compounds have been synthesized by the reaction of salts of bivalent metal ions (a=ZnII, b=CuII, c=NiII, d=CoII) with the bis(benzoylhydrazone) derivative of 4,6‐diacetylresorcinol (H4L). Three kinds of complexes have been obtained: homodinuclear compounds [M2(H2L)2]⋅nH2O (1 a, 1 b, 1 c, and 1 d), homotetranuclear compounds [M4(L)2]⋅n(solv) (2 a and 2 c), and heterotetranuclear compounds [Zn2M2(L)2]⋅n(solv) (2 ab, 2 ac, and 2 ad). The structures of the free ligand H4L⋅2 DMSO and its complexes [Zn2(H2L)2(DMSO)2] (1 a*), [Zn4(L)2(DMSO)6] (2 a*), and [Zn0.45Cu3.55(L)2(DMSO)6]⋅2 DMSO (2 ab*) were elucidated by single‐crystal X‐ray diffraction. The ligand shows luminescence properties and its fluorimetric behavior towards MII metals (M=Zn, Cu, Ni and Co) has been studied. Furthermore, the solid‐state luminescence properties of the ligand and compounds have been determined at room temperature. 1H NMR spectroscopic monitoring of the reaction of H4L with ZnII showed the deprotonation sequence of the OH/NH groups upon metal coordination. Heteronuclear reactions have also been monitored by using ESI‐MS and spectrofluorimetric techniques.
Synthesis of 3,8‐Dichloro‐6‐ethyl‐1,2,5,7‐tetramethyl–BODIPY from an Asymmetric Dipyrroketone and Reactivity Studies at the 3,5,8‐Positions
Authors: Zhao Ning , Vicente M. Graça H. , Fronczek Frank R. , Smith Kevin M.
Published: March 2015

The asymmetric BODIPY 1 a (BODIPY=4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene), containing two chloro substituents at the 3,8‐positions and a reactive 5‐methyl group, was synthesized from the asymmetric dipyrroketone 3, which was readily obtained from available pyrrole 2 a. The reactivity of 3,8‐dichloro‐6‐ethyl‐1,2,5,7‐tetramethyl‐BODIPY 1 a was investigated by using four types of reactions. This versatile BODIPY undergoes regioselective Pd0‐catalyzed Stille coupling reactions and/or regioselective nucleophilic addition/elimination reactions, first at the 8‐chloro and then at the 3‐chloro group, using a variety of organostannanes and N‐, O‐, and S‐centered nucleophiles. On the other hand, the more reactive 5‐methyl group undergoes regioselective Knoevenagel condensation with an aryl aldehyde to produce a monostyryl‐BODIPY, and oxidation with 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) gives the corresponding 5‐formyl‐BODIPY. Investigation of the reactivity of asymmetric BODIPY 1 a led to the preparation of a variety of functionalized BODIPYs with λmax of absorption and emission in the ranges 487–587 and 521–617 nm, respectively. The longest absorbing/emitting compound was the monostyryl‐BODIPY 16, and the largest Stokes shift (49 nm) and fluorescence quantum yield (0.94) were measured for 5‐thienyl‐8‐phenoxy‐BODIPY 15. The structural properties (including 16 X‐ray structures) of the new series of BODIPYs were investigated.
Cyclic isoDGR and RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds are Integrin Antagonists
Authors: Panzeri Silvia , Zanella Simone , Arosio Daniela , Vahdati Leila , Dal Corso Alberto , Pignataro Luca , Paolillo Mayra , Schinelli Sergio , Belvisi Laura , Gennari Cesare , Piarulli Umberto
Published: March 2015

The cyclo[DKP‐isoDGR] peptidomimetics 2–5, containing bifunctional diketopiperazine (DKP) scaffolds that differ in the configuration of the two DKP stereocenters and in the substitution at the DKP nitrogen atoms, were prepared and examined in vitro in competitive binding assays with purified αvβ3 and αvβ5 integrin receptors. IC50 values ranged from low nanomolar (ligand 3) to submicromolar with αvβ3 integrin. The biological activities of ligands cyclo[DKP3‐RGD] 1 and cyclo[DKP3‐isoDGR] 3, bearing the same bifunctional DKP scaffold and showing similar αVβ3 integrin binding values, were compared in terms of their cellular effects in human U373 glioblastoma cells. Compounds 1 and 3 displayed overlapping inhibitory effects on the FAK/Akt integrin activated transduction pathway and on integrin‐mediated cell infiltration processes, and qualify therefore, despite the different RGD and isoDGR sequences, as integrin antagonists. Both compounds induced apoptosis in glioma cells after 72 hour treatment.
Vinylation of Aldehydes Using Mn/Cr Alloy and a N4‐Ligand/NiII‐Catalyst
Authors: Harnying Wacharee , Berkessel Albrecht
Published: March 2015

We report an efficient and practical protocol for the Cr/Ni‐catalyzed vinylation of aldehydes, based on the use of Mn/Cr alloy (ca. 10 % Cr) and TMSCl. No additional Cr salts need to be added. In the presence of NiCl2 (0.3 mol %) and a bis(ketimino)‐2,2′‐bipyridine as N4‐chelating ligand (1 mol %), the vinylations proceed smoothly at room temperature. The presence of catalytic amounts of MeOH and LiOAc as additives was found to further promote the efficiency of the catalytic system, even in the absence of the ligand. Detailed reaction monitoring revealed that LiOAc accelerates the product alcohol silylation, thus increasing the turnover rate.
Stereoselective Peterson Olefinations from Bench‐Stable Reagents and N‐Phenyl Imines
Authors: Das Manas , Manvar Atul , Jacolot Maïwenn , Blangetti Marco , Jones Roderick C. , O'Shea Donal F.
Published: March 2015

The synthesis of bench‐stable α,α‐bis(trimethylsilyl)toluenes and tris(trimethylsilyl)methane is described and their use in stereoselective Peterson olefinations has been achieved with a wide substrate scope. Product stereoselectivity was poor with carbonyl electrophiles (E/Z ∼1:1 to 4:1) though this was significantly improved by employing the corresponding substituted N‐benzylideneaniline (up to 99:1) as an alternative electrophile. The olefination byproduct was identified as N,N‐bis(trimethylsilyl)aniline and could be easily separated from product by aqueous acid extraction. Evidence for an autocatalytic cycle has been obtained.
Tunable Porosities and Shapes of Fullerene‐Like Spheres
Authors: Dielmann Fabian , Fleischmann Matthias , Heindl Claudia , Peresypkina Eugenia V. , Virovets Alexander V. , Gschwind Ruth M. , Scheer Manfred
Published: March 2015

The formation of reversible switchable nanostructures monitored by solution and solid‐state methods is still a challenge in supramolecular chemistry. By a comprehensive solid state and solution study we demonstrate the potential of the fivefold symmetrical building block of pentaphosphaferrocene in combination with CuI halides to switch between spheres of different porosity and shape. With increasing amount of CuX, the structures of the formed supramolecules change from incomplete to complete spherically shaped fullerene‐like assemblies possessing an Ih‐C80 topology at one side and to a tetrahedral‐structured aggregate at the other. In the solid state, the formed nano‐sized aggregates reach an outer diameter of 3.14 and 3.56 nm, respectively. This feature is used to reversibly encapsulate and release guest molecules in solution.
ChemInform Abstract: Low‐Temperature Topochemical Transformation of Bi13Pt3I7 into the New Layered Honeycomb Metal Bi12Pt3I5.
Authors: Kaiser Martin , Rasche Bertold , Isaeva Anna , Ruck Michael
Published: March 2015

Single crystals of Bi13Pt3I7 (prepared from a mixture of H2 treated Bi, Pt, and BiI3 at 380 °C for 6 d).
ChemInform Abstract: BaFAlSi and BaFAlGe: First Transition Metal‐Free LaOAgS‐Type Fluoride Tetrelides.
Authors: Charkin Dmitri O. , Plokhikh Igor V. , Kuznetsov Alexey N. , Kazakov Sergey M.
Published: March 2015

BaFAlSi (I) and BaFAlGe (II) are obtained from attempts to prepare a series of new representatives of Al and Ga tretrelides with the “1111” LaOAgS structure.
ChemInform Abstract: A Study on Photoluminescence and Energy Transfer of SrAlSi4N7:Eu2+, Ce3+ Phosphors for Application in White‐Light LED.
Authors: Chen Lei , Liu Ronghui , Zhuang Weidong , Liu Yuanhong , Hu Yunsheng , Zhou Xiaofang , Ma Xiaole
Published: March 2015

A series of Ce3+ and Eu2+ co‐activated SrAlSi4N7 phosphors is prepared by solid‐state reaction of stoichiometric amounts of Sr3N2, AlN, Si3N4, EuN, and CeN (Mo crucible, 1650 °C, 8 h, 5% H2/N2).
ChemInform Abstract: Increasing the Thermoelectric Figure of Merit of Tetrahedrites by Co‐Doping with Nickel and Zinc.
Authors: Lu Xu , Morelli Donald T. , Xia Yi , Ozolins Vidvuds
Published: March 2015

Cu10.5Ni1.5‐xZnxSb4S13 is prepared by melting of the elements (evacuated quartz tubes, 923 K, 12 h; cooling to 273 K with a rate of 0.4 K/min).
ChemInform Abstract: Experimental Investigation of Phase Equilibria in the Co—Hf System.
Authors: Lu Xingxu , Cheng Kaiming , Liu Shuhong , Li Kai , Zheng Feng , Du Yong
Published: March 2015

Phase equilibria in the Co‐Hf binary system are investigated by XRD, TEM, SEM, electron probe microanalysis, and DSC on annealed and as‐cast alloys.
ChemInform Abstract: O‐Monoacyltartaric Acid Catalyzed Enantioselective Conjugate Addition of a Boronic Acid to Dienones: Application to the Synthesis of Optically Active Cyclopentenones.
Authors: Sugiura Masaharu , Kinoshita Ryo , Nakajima Makoto
Published: March 2015

The enantioselective addition of styrylboronic acid (II) to symmetrical and unsymmetrical dienones, catalyzed by O‐monoacyltartaric acid, affords monostyrylated adducts [ct.
ChemInform Abstract: Palladium‐Catalyzed Decarboxylative Generation and Asymmetric Allylation of α‐Imino Anions
Authors: Qian Xiaoyan , Ji Pengfei , He Chang , Zirimwabagabo Jean‐Olivier , Archibald Michelle M. , Yeagley Andrew A. , Chruma Jason J.
Published: March 2015

using (S,S)‐f‐binaphane (BPF) as chiral catalyst ligand
ChemInform Abstract: Stereoselective Synthesis of (E)‐3,3‐Diaryl and (E)‐3‐Aryl‐3‐aryloxy Allylamines and Allylalcohols from trans‐Cinnamyl Chloride and Alcohol.
Authors: Limberger Jones , Claudino Thiago S. , Monteiro Adriano L.
Published: March 2015

Vinyl bromides (I) are used as substrates in cross‐coupling reactions furnishing arylated products (III) and (V) in good to excellent yields and complete retention of the (E)‐configuration.
ChemInform Abstract: Efficient Mukaiyama Aldol Reaction in Water with TiO4 Tetrahedra on a Hydrophobic Mesoporous Silica Surface.
Authors: Shintaku Hiroshi , Nakajima Kiyotaka , Kitano Masaaki , Hara Michikazu
Published: March 2015

TiO4 deposited onto 1H,1H,2H,2H‐tridecafluorooctyl‐modified mesoporous silica (TFS) shows the best results in the surfactant‐free aqueous Mukaiyama reaction of benzaldehyde and 1‐(trimethylsilyloxy)cyclohexene of the tested catalysts.
ChemInform Abstract: Iridium‐Catalyzed Hydrogenation of Carboxylic Acid Esters.
Authors: Junge Kathrin , Wendt Bianca , Jiao Haijun , Beller Matthias
Published: March 2015

A variety of esters is reduced for the first time selectively using an iridium pincer‐type complex as catalyst.
ChemInform Abstract: Iridium—CNP Complex Catalyzed Cross‐Coupling of Primary Alcohols and Secondary Alcohols by a Borrowing Hydrogen Strategy.
Authors: Wang Dawei , Zhao Keyan , Yu Xin , Miao Hongyan , Ding Yuqiang
Published: March 2015

Ketones are efficiently synthesized by the title reaction.
ChemInform Abstract: Silver‐Catalyzed Transformation of Propargylic Amine N‐Oxides to Enones and Acyloxy Ketones via Isoxazolinium Intermediates.
Authors: Cui Jian‐Fang , Kung Karen Ka‐Yan , Ko Hok‐Ming , Hui Tsz‐Wai , Wong Man‐Kin
Published: March 2015

The propargylic amine N‐oxides are formed in situ by oxygenation of the corresponding propargyl amines.
ChemInform Abstract: Iodo Meyer—Schuster Rearrangement of 3‐Alkoxy‐2‐yn‐1‐ols for β‐Mono (Exclusively Z‐Selective)‐/Disubstituted α‐Iodo‐α,β‐Unsaturated Esters.
Authors: Puri Surendra , Thirupathi Nuligonda , Sridhar Reddy Maddi
Published: March 2015

An efficient synthesis of linear α‐iodo‐α,β‐unsaturated esters from readily accessible propargylic alcohols is described.
ChemInform Abstract: Direct Synthesis of Allylic Thioethers under Greener Conditions: A Solvent‐ and Catalyst‐Free Approach.
Authors: Tabarelli Greice , Godoi Marcelo , Canto Romulo F. S. , Mora Jose R. , Nome Faruk , Braga Antonio L.
Published: March 2015

A new, environmentally friendly approach for the synthesis of different allylic thioethers (III) directly from allylic alcohols and thiols is developed.
ChemInform Abstract: Phase‐Transfer Catalysis in Oxidations Based on the Covalent Bonding of Hydrogen Peroxide to Amphiphilic Flavinium Salts.
Authors: Zelenka Jan , Hartman Tomas , Klimova Katerina , Hampl Frantisek , Cibulka Radek
Published: March 2015

Sulfoxides (II) are synthesized by two‐phase oxidation of sulfides (I) with hydrogen peroxide using a bridged flavinium salt as catalyst.
ChemInform Abstract: A Green Protocol for the Pd Catalyzed Ligand Free Homocoupling Reaction of Arylboronic Acids under Ambient Conditions.
Authors: Dwivedi Seema , Bardhan Soumik , Ghosh Prasanjit , Das Sajal
Published: March 2015

Isopropyl myristate acts as a phase transfer catalyst.
ChemInform Abstract: The Palladium(II) Complex of N,N‐Diethyl‐1‐ferrocenyl‐3‐thiabutanamine: Synthesis, Solution and Solid State Structure and Catalytic Activity in Suzuki—Miyaura Reaction.
Authors: Damljanovic Ivan , Stevanovic Dragana , Pejovic Anka , Ilic Danijela , Zivkovic Marija , Jovanovic Jovana , Vukicevic Mirjana , Bogdanovic Goran A. , Radulovic Niko S. , Vukicevic Rastko D.
Published: March 2015

The title complex generated in situ is an excellent catalyst in Suzuki—Miyaura coupling.
ChemInform Abstract: LiAlH4‐Promoted Tandem Reduction/Oxidation of Fluorenyl Derivatives under Air.
Authors: Matviiuk Tetiana , Menendez Christophe , Carayon Chantal , Saffon Nathalie , Voitenko Zoia , Lherbet Christian , Baltas Michel
Published: March 2015

Since a 9‐hydroxyfluorenyl derivative such as (II) is observed as by‐product in the reduction of a pyrrolidine‐2,5‐dione such as (I), the process is investigated in detail.
ChemInform Abstract: Iodine‐Promoted Sequential C(sp3)—H Functionalization Reactions: An Annulation Strategy for the Construction of 3‐Methylthio‐4‐arylmaleimides.
Authors: Gao Qinghe , Wu Xia , Li Yuhong , Liu Shan , Meng Xianggao , Wu Anxin
Published: March 2015

Methylthio‐substituted maleimides are synthesized by a novel annulation strategy from methyl ketones, actetamides, and DMSO in the presence of I2 via an iodination/Kornblum oxidation/amidation/cyclization sequence.
ChemInform Abstract: α,α‐Dichlorination of Oxindole Derivatives Using (Dichloroiodo)benzene.
Authors: Murphy Graham K. , Abbas Farhana Z. , Poulton Amy V.
Published: March 2015

3‐Diazo‐2‐oxindoles (I) and (III), synthesized from isatins, are rapidly and chemoselectively dichlorinated with PhICl2 in the presence of pyridine under mild conditions in good to excellent yields.
ChemInform Abstract: Friedel—Crafts Alkylation of Indoles Exclusively in Water Catalyzed by Ionic Liquid Supported on a Polyacrylonitrile Fiber: A Simple “Release and Catch” Catalyst.
Authors: Shi Xian‐Lei , Lin Huikun , Li Pengyu , Zhang Wenqin
Published: March 2015

Title reaction synthesizes bis(indolyl)methanes under mild and environmentally friendly conditions in high yields.
ChemInform Abstract: Tandem Insertion—Cyclization Reaction of Isocyanides in the Synthesis of 1,4‐Diaryl‐1H‐imidazoles: Presence of N‐Arylformimidate Intermediate.
Authors: Pooi Benjamin , Lee Jeongbin , Choi Kyujin , Hirao Hajime , Hong Soon Hyeok
Published: March 2015

Benzyl isocyanides and the activated methylene analogue (IX) can be used as starting materials in the reaction with aryl isocyanides.
ChemInform Abstract: Synthesis of Bright Alkenyl‐1H‐1,2,4‐triazoles: A Theoretical and Photophysical Study.
Authors: Cebrian Cristina , de Mata Munoz Juan , Strassert Cristian Alejandro , Prieto Pilar , Diaz‐Ortiz Angel , De Cola Luisa , de la Hoz Antonio
Published: March 2015

π‐Conjugated title triazoles are synthesized in water under microwave irradiation with good yields.
ChemInform Abstract: Catalytic Oxidation of β‐Keto Esters by Manganese(III)/Cobalt(II) and Consecutive Cyclization to Heterocycles.
Authors: Ju Yeming , Miao Di , Seo Jeong Gil , Koo Sangho
Published: March 2015

β‐Keto esters are catalytically oxidized by Mn(III)/Co(II)‐system to α‐oxo esters, which directly cyclize to dihydropyrans or furans.
ChemInform Abstract: Combining Silver Catalysis and Organocatalysis: A Sequential Michael Addition/Hydroalkoxylation One‐Pot Approach to Annulated Coumarins.
Authors: Hack Daniel , Chauhan Pankaj , Deckers Kristina , Hermann Gary N. , Mertens Lucas , Raabe Gerhard , Enders Dieter
Published: March 2015

By merging primary amine catalysis with silver‐catalysis, a series of functionalized coumarin derivatives (III) and (V) is obtained in good yields and good to excellent enantioselectivities.
ChemInform Abstract: An Efficient and Green Synthesis of Flavones Using Natural Organic Acids as Promoter under Solvent‐Free Condition.
Authors: Thorat Nitin M. , Kote Santosh R. , Thopate Shankar R.
Published: March 2015

Naturally occurring acids are used as environmentally‐friendly acid catalyst in the synthesis of flavones (II) by cyclodehydration of 1‐(2‐hydroxyphenyl)‐3‐aryl‐1,3‐propanediones (I).
ChemInform Abstract: Transition‐Metal‐Free Arylation of N‐Alkyl‐tetrahydroisoquinolines under Oxidative Conditions: A Convenient Synthesis of C1‐Arylated Tetrahydroisoquinoline Alkaloids.
Authors: Singh Kamal Nain , Kessar Satinder V. , Singh Paramjit , Singh Pushpinder , Kaur Manjot , Batra Aanchal
Published: March 2015

The method is applied to the synthesis of cryptostyline II (IXa) and cryptostyline III (IXb).
ChemInform Abstract: An Eco‐Friendly and Water Mediated Product Selective Synthesis of 2‐Aminopyrimidines and Their in vitro Antibacterial Evaluation.
Authors: Nagarajan Sangaraiah , Shanmugavelan Poovan , Sathishkumar Murugan , Selvi Ramasamy , Ponnuswamy Alagusundaram , Harikrishnan Hariharan , Shanmugaiah Vellasamy , Murugavel Saminathan
Published: March 2015

Three of the synthesized compounds, i.e.
ChemInform Abstract: Electrochemical Synthesis of Potassium Aryltrifluoroborates.
Authors: Nascimento Wilson , Oliveira Jadson L. , Freitas Juliano C. R. , Navarro Marcelo , Menezes Paulo H.
Published: March 2015

The method is applied to the synthesis of compound (VI), a fragment of the natural product combretastatin D2.
ChemInform Abstract: Rapid Access to Benzoxaphospholes and Their Spiro Analogues by a Three‐Component Coupling Involving Arynes, Phosphines, and Activated Ketones.
Authors: Bhunia Anup , Roy Tony , Gonnade Rajesh G. , Biju Akkattu T.
Published: March 2015

A multicomponent coupling reaction involving in situ generated arynes, phosphine (III) or arsine (V), as well as various acyclic and cyclic activated carbonyl compounds (II), (VII), and (IX) is described.
ChemInform Abstract: Silver‐Catalyzed Carbonphosphonation of α,α‐Diaryl Allylic Alcohols: Synthesis of β‐Aryl‐γ‐ketophosphonates.
Authors: Mi Xia , Wang Chenyang , Huang Mengmeng , Wu Yusheng , Wu Yangjie
Published: March 2015

The silver‐catalyzed radical reaction of phosphonate (II) with symmetrical α,α‐diaryl allylic alcohols (I) is accompanied by a 1,2‐migration of an aryl group to afford β‐aryl‐γ‐ketophosphonates (III).
ChemInform Abstract: Stereoselective Synthesis of Tricyclic Diproline Analogues that Mimic a PPII Helix: Structural Consequences of Ring‐Size Variation.
Authors: Soicke Arne , Reuter Cedric , Winter Matthias , Neudoerfl Joerg‐Martin , Schloerer Nils , Kuehne Ronald , Schmalz Hans‐Guenther
Published: March 2015

Synthons (VI) and (Xb) are prepared and used in the peptide coupling with proline derivative (XI).
ChemInform Abstract: A General and Practical Palladium‐Catalyzed Monoarylation of β‐Methyl C(sp3)—H of Alanine.
Authors: Chen Kai , Zhang Shuo‐Qing , Xu Jing‐Wen , Hu Fang , Shi Bing‐Feng
Published: March 2015

The title reaction uses an 8‐aminoquinoline auxiliary as directing group and is compatible with a variety of functional groups with complete retention of chirality.
ChemInform Abstract: Amphirionin‐4 with Potent Proliferation‐Promoting Activity on Bone Marrow Stromal Cells from a Marine Dinoflagellate Amphidinium Species
Authors: Tsuda Masashi , et al. et al.
Published: March 2015

isolation and structure elucidation of amphirionin‐4 (I)
ChemInform Abstract: Recent Progress on Synthesis, Multi‐Scale Structure, and Properties of Y—Si—O Oxides
Authors: Sun Ziqi , Li Meishuan , Zhou Yanchun
Published: March 2015

Review: 179 refs.
ChemInform Abstract: Zeolite‐Like Metal—Organic Frameworks (ZMOFs): Design, Synthesis, and Properties
Authors: Eddaoudi Mohamed , Sava Dorina F. , Eubank Jarrod F. , Adil Karim , Guillerm Vincent
Published: March 2015

Review: 152 refs.
ChemInform Abstract: Isohexides as Versatile Scaffolds for Asymmetric Catalysis
Authors: Kadraoui Mohammed , Maunoury Thibault , Derriche Zoubir , Guillarme Stephane , Saluzzo Christine
Published: March 2015

Review: [46 refs.
ChemInform Abstract: Advances in Microwave‐Assisted Synthesis for Five‐Membered N‐Heterocycle Synthesis
Authors: Kaur Navjeet
Published: March 2015

Review: 110 refs.
ChemInform Abstract: The Chemical Biology of Dimethylsulfoniopropionate
Authors: Dickschat Jeroen S. , Rabe Patrick , Citron Christian A.
Published: March 2015

Review: 117 refs.
Bi2O3@Reduced Graphene Oxide Nanocomposite: An Anode Material for Sodium‐Ion Storage
Authors: Nithya Chandrasekaran
Published: March 2015

The high capacity, excellent cyclability, and good rate capability of reduced graphene oxide (rGO) anchored with Bi2O3 nanocomposite for sodium‐ion batteries is reported. A simple reduction method is adapted to deposit spherical Bi2O3 nanoparticles on the surface of rGO sheets. The surfactant cetyltrimethylammonium bromide (CTAB) plays a major role in controlling the morphology of the Bi2O3 nanoparticles. This Bi2O3@rGO nanocomposite has the advantages of high reversible capacity with a capacity retention (at high rate) of 70.2 % after 200 cycles at a current density of 350 mA g−1. This superior performance can be attributed to the fact that rGO sheets hamper the volume expansion of Bi2O3 nanoparticles and result in faster diffusion of Na+ ions (diffusion coefficient: 5.12×10−8 cm2 s−1) and smaller internal resistance (84.17 Ω) compared with pristine Bi2O3 nanoparticles. The results suggest that anchoring rGO sheets with metal oxides is one of the simplest ways to enhance the electrochemical performance of sodium‐ion batteries.
Development and evaluation of short forms of the Pain Catastrophizing Scale and the Pain Self‐efficacy Questionnaire
Authors: McWilliams L.A. , Kowal J. , Wilson K.G.
Published: March 2015

Background

To facilitate efficient screening and reduce the length of comprehensive self‐report batteries, a four‐item short form of the Pain Catastrophizing Scale (PCS) and a two‐item short form of the Pain Self‐Efficacy Questionnaire (PSEQ) have been developed and evaluated in samples of patients with arm and upper extremity pain.

Aims

The first aim of this study was to evaluate these short forms in a heterogeneous sample of patients seeking treatment for chronic musculoskeletal pain, using a priori criteria for determining adequate internal consistency, construct validity and sensitivity to change. In addition, the findings of past studies were used to identify items suitable for new and potentially stronger short forms of these measures.

Method

Data were provided by 280 patients who completed the original PCS and PSEQ as part of an interdisciplinary rehabilitation programme.

Results

The previously developed four‐item PCS and the newly developed six‐item short form of the PCS both met the internal consistency and construct validity criteria. They did not meet the criterion regarding sensitivity to change. However, similar to what was obtained using the original PCS, large effect sizes were found when using these short forms to examine pre‐treatment to post‐treatment changes in catastrophizing. For the PSEQ, the new four‐item short form was clearly superior to the other alternatives and met all three criteria.

Conclusion

The strongest short forms of the PCS and PSEQ could facilitate the assessment of pain catastrophizing and self‐efficacy in situations in which the use of the longer original measures is not feasible.
Bootstrap Replacement to Validate the Influence of the Economic Cycle on the Structure and the Accuracy Level of Business Failure Prediction Models
Authors: Manzaneque Montserrat , GarcíA‐Pérez‐De‐Lema Domingo , Antón Renart Marcos
Published: March 2015

The aim of this study was to answer the question of how the economic cycle affects the stability and efficiency of business failure prediction models, using bootstrap replacement method for validation. We analyse 2228 Spanish small and medium‐sized enterprises for the period 2001–2009, and divide it into three different phases of the economic cycle (growth, crisis, recession). We find that the structure and the ability of business failure prediction models are different according to the economic cycle. These findings are relevant for the debate on the most suitable financial ratios when developing business failure prediction models and to pose their accuracy level in these prediction models. Copyright © 2015 John Wiley & Sons, Ltd.
Informal Care Motivations and Intergenerational Transfers in European Countries
Authors: Jiménez‐Martín Sergi , Vilaplana Prieto Cristina
Published: March 2015

This work sets out to analyze the motivations adult children may have to provide informal care, considering the monetary transfers they receive from their parents. Traditional motivations, such as altruism and exchange, are matched against more recent social bond theories. Our findings indicate that informal caregivers receive less frequent and less generous transfers than non‐caregivers; that is, caregivers are more prone to suppress their self‐interested motivations in order to prioritize the well being of another person. Additionally, long‐term public care benefits increase both the probability of receiving a transfer and its amount, with this effect being more intense for both the poorest and richest households. Our findings suggest that if long‐term care benefits are intended to increase the recipients' welfare and represent a higher fraction of total income for the poorest households, the effectiveness of these long‐term care policies may be diluted. Copyright © 2015 John Wiley & Sons, Ltd.
Practice Patterns among Entrants and Incumbents in the Home Health Market after the Prospective Payment System was Implemented
Authors: Kim Hyunjee , Norton Edward C.
Published: March 2015

Home health care expenditures were the fastest growing part of Medicare from 2001–2009, despite the implementation of prospective payment. Prior research has shown that home health agencies adopted two specific strategies to take advantage of Medicare policies: provide at least 10 therapy visits to get an enormous marginal payment and recertify patients for additional episodes. We study whether there is heterogeneity in the adoption of those strategic behaviors between home health agency entrants and incumbents and find that entrants were more likely to adopt strategic practice patterns than were incumbents. We also find that for‐profit incumbents mimicked one of the practice patterns following entrants in the same market. Our findings suggest that it is important to understand the heterogeneity in providers' behavior and how firms interact with each other in the same market. These findings help explain the rapid rise in expenditures in the home health care market. Copyright © 2015 John Wiley & Sons, Ltd.
Local Variability in Long‐Term Care Services: Local Autonomy, Exogenous Influences and Policy Spillovers
Authors: Fernandez José‐Luis , Forder Julien
Published: March 2015

In many countries, public responsibility over the funding and provision of long‐term care services is held at the local level. In such systems, long‐term care provision is often characterised by significant local variability. Using a panel dataset of local authorities over the period 2002–2012, the paper investigates the underlying causes of variation in gross social care expenditure for older people in England. The analysis distinguishes between factors outside the direct control of policy makers, local preferences and local policy spillovers. The results indicate that local demand and supply factors, and to a much lesser extent local political preferences and spatial policy spillovers, explain a large majority of the observed variation in expenditure. Copyright © 2015 John Wiley & Sons, Ltd.
Acceptability of programme budgeting and marginal analysis as a tool for routine priority setting in Indigenous health
Authors: Otim Michael E. , Asante Augustine D. , Kelaher Margaret , Anderson Ian P. , Jan Stephen
Published: March 2015

Objective

This study aimed to examine the acceptability of programme budgeting and marginal analysis (PBMA) as a tool for priority setting in the Indigenous health sector.

Methods

The study uses a mix of quantitative and qualitative methods. A survey of key decision makers in Indigenous health in Victoria was conducted to assess the acceptability of PBMA as a potential tool for priority setting. Respondents comprised 24 bureaucrats from the Victorian Department of Human Services (DHS) and 26 senior executives from the aboriginal community controlled health sector (ACCHS) in Victoria. The survey instrument included both closed‐ended and open‐ended questions and was administered face‐to‐face by a trained researcher in 2007–2008. Closed‐ended questions were analysed using descriptive statistics, and content analysis was used for the open‐ended ones.

Results

The PBMA was well received as having the potential to improve priority setting processes in Indigenous health. Sixty‐nine percent of the DHS respondents felt that PBMA was acceptable as a routine decision‐making tool, and nearly 80% of ACCHS respondents thought that PBMA was intuitively appealing and would most probably be an acceptable priority setting approach in their organisations. The challenges of using PBMA were related to resource constraints and data intensity.

Conclusion

Programme budgeting and marginal analysis is potentially acceptable within the ACCHS and was perceived as useful in terms of assisting the decision maker to maximise health outcomes, but data systems need to be re‐oriented to address its significant data needs.

Implication

Proper guidelines need to be developed to facilitate PBMA application within the Indigenous‐controlled community health sector. Copyright © 2015 John Wiley & Sons, Ltd.
Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation
Authors: Martinez de Pinillos Bayona Alejandra , Moore Caroline M. , Loizidou Marilena , MacRobert Alexander J. , Woodhams Josephine H.
Published: March 2015

Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes. There is a wide range of agents suitable for PCI‐based delivery including toxins, oligonucleotides, genes and immunoconjugates which demonstrates the versatility of this technique. The basic mechanism of PCI involves triggering release of the agent from endolysosomes within the target cells using a photosensitiser which is selectively retained with the endolysosomal membranes. Excitation of the photosensitiser by visible light leads to disruption of the membranes via photooxidative damage thereby releasing the agent into the cytosol. This treatment enables the drugs to reach their intended subcellular target more efficiently and improves their efficacy. In this review we summarise the applications of this technique with the main emphasis placed on cancer chemotherapy.
Non‐linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy
Authors: Cicchi Riccardo , Baria Enrico , Matthäus Christian , Lange Marta , Lattermann Annika , Brehm Bernhard R. , Popp Jürgen , Pavone Francesco Saverio
Published: March 2015

Atherosclerosis is one of the leading causes of death in the Western World and its characterization is extremely interesting from the diagnostic point of view. Here, we employed combined SHG‐FLIM microscopy to characterize arterial tissue with atherosclerosis. The shorter mean fluorescence lifetime measured within plaque depositions (1260 ± 80 ps) with respect to normal arterial wall (1480 ± 100 ps) allowed discriminating collagen from lipids. SHG measurements and image analysis demonstrated that the normal arterial wall has a more anisotropic Aspect Ratio (0.37 ± 0.02) with respect to plaque depositions (0.61 ± 0.02) and that the correlation length can be used for discriminating collagen fibre bundles (2.0 ± 0.6 µm) from cholesterol depositions (4.1 ± 0.6 µm). The presented method has the potential to find place in a clinical setting as well as to be applied in vivo in the near future.

Graphic composition of SHG and FLIM images representing normal arterial wall and plaque depositions.

magnified image

Graphic composition of SHG and FLIM images representing normal arterial wall and plaque depositions.
Probing the reactivity of microhydrated α‐nucleophile in the anionic gas‐phase SN2 reaction
Authors: Zhao Wen‐Yang , Yu Jie , Ren Si‐Jia , Wei Xi‐Guang , Qiu Fang‐Zhou , Li Peng‐Hui , Li He , Zhou Yi‐Peng , Yin Chang‐Zhen , Chen An‐Pu , Li Hao , Zhang Lei , Zhu Jun , Ren Yi , Lau Kai‐Chung
Published: March 2015

To probe the kinetic performance of microsolvated α‐nucleophile, the G2(+)M calculations were carried out for the gas‐phase SN2 reactions of monohydrated and dihydrated α‐oxy‐nucleophiles XO−(H2O)n = 1,2 (X = HO, CH3O, F, Cl, Br), and α‐sulfur‐nucleophile, HSS−(H2O)n = 1,2, toward CH3Cl. We compared the reactivities of hydrated α‐nucleophiles to those of hydrated normal nucleophiles. Our calculations show that the α‐effect of monohydrated and dihydrated α‐oxy‐nucleophiles will become weaker than those of unhydrated ones if we apply a plot of activation barrier as a function of anion basicity. Whereas the enhanced reactivity of monohydrated and dihydrated ROO− (R = H, Me) could be observed if compared them with the specific normal nucleophiles, RO− (R = H, Me). This phenomena can not be seen in the comparisons of XO−(H2O)n = 1,2 (X = F, Cl, Br) with ClC2H4O−(H2O)n = 1,2, a normal nucleophile with similar gas basicity to XO−(H2O)n = 1,2. These results have been carefully analyzed by natural bond orbital theory and activation strain model. Meanwhile, the relationships between activation barriers with reaction energies and the ionization energies of α‐nucleophile are also discussed. © 2015 Wiley Periodicals, Inc.
SUPPORTING THE SUPPORTERS: A RANDOMIZED CONTROLLED TRIAL OF INTERVENTIONS TO ASSIST THE LEADERS OF CANCER SUPPORT GROUPS
Authors: Zordan Rachel , Butow Phyllis , Kirsten Laura , Charles Margaret , Hobbs Kim , Batterby Eugenie , Friedsam John , O'Reilly Amanda , Juraskova Ilona
Published: March 2015

As more skilled cancer support group leaders create better outcomes for group members, it is important to provide training for this population. The aim of this randomized controlled trial was to evaluate the effect of a low resource demanding (LRD) versus a high resource demanding (HRD) intervention. Leaders were randomized to receive either an LRD (access to a website and discussion forum only) or an HRD intervention (access to the website and discussion forum, DVD, and manual, plus a 2‐day training workshop). Pre‐ and postintervention assessment was conducted using 3 standardized measures. Sixty‐five leaders (HRD n = 35; LRD n = 30) participated, with postintervention data collected from 54 leaders (83%). Pre‐ and postintervention, leaders reported low levels of challenge and high levels of psychological well‐being and confidence. Comparative analysis revealed no significant group differences (all p > .05). However, in semistructured interviews (n = 12) and focus groups (n = 8), leaders reported that training had positive effects, despite barriers to intervention use.
A PRELIMINARY EXAMINATION OF THE MEANING AND EFFECT OF LIMITED LITERACY IN THE LIVES OF PEOPLE WITH SERIOUS MENTAL ILLNESS
Authors: Lincoln Alisa K. , Arford Tammi , Doran Meghan V. , Guyer Margaret , Hopper Kim
Published: March 2015

The relationship between literacy and health has been well documented: research shows that people with limited literacy skills have worse health outcomes for numerous chronic conditions. However, little is known about how literacy relates to mental health, including access to treatment and recovery. A pilot study was conducted with mental health services users with varying literacy skills at two urban, public mental health clinics to more fully understand how literacy affects the lives of people living with serious mental illness. The study was designed using a Community‐Based Participatory Research approach; mental health service users informed the development of the interview guide. Findings demonstrate that those with limited literacy skills experience increased stigma, have fewer options for accessing information about conditions and treatment plans, and may be excluded from certain cognitive‐behavioral treatments that require basic literacy skills. These barriers can significantly affect service utilization and mental health outcomes.
CAREER READINESS: A POTENTIAL PATHWAY THROUGH WHICH URBAN YOUTH'S EXPOSURE TO STRESS INFLUENCES ADULT HEALTH
Authors: Johnson Sarah Lindstrom , Tandon S. Darius , Cheng Tina L.
Published: March 2015

Although a growing body of research provides support for the detrimental effects of stress during childhood on future adult health, less is known about how stress disrupts normal developmental processes. This pathway may be particularly relevant for urban adolescents who are exposed to additional contextual stressors. This study will longitudinally explore how psychological stress from multiple domains influences urban adolescents’ career readiness. A total of 200 youth (aged 14–21 years) completed surveys assessing their school, family, neighborhood, and health stress. Path analysis using a parallel process model found that school and neighborhood stress at 6 months were significantly associated with decreased career readiness at 15 months. Health stress at baseline was related to an increased report of career readiness at 15 months, which was moderated by parental closeness. These findings suggest that experiences of stress for urban youth negatively affect their planning for the future, particularly in the absence of supportive parental relationships.
High conversion efficiency of Japanese cedar hydrolyzates into acetic acid by co‐culture of Clostridium thermoaceticum and Clostridium thermocellum
Authors: Rabemanolontsoa Harifara , Kuninori Yoshimizu , Saka Shiro
Published: March 2015

BACKGROUND

Acetic acid is an important reagent and precursor in chemical and material industries. It is largely manufactured from fossil resources, but with increasing environmental concerns and uncertain petroleum availability, producing organic acids from renewable biomass has become a priority. Several researchers have demonstrated acetic acid production from model compounds, food products or a minor portion of lignocellulosic biomass but the simultaneous fermentation of all biomass‐derived products has not been reported yet. This work demonstrates the unique capabilities of Clostridium thermoaceticum and Clostridium thermocellum in co‐culture to convert most products obtained from hot‐compressed water treatment of Japanese cedar into acetic acid.

RESULTS

Under an optimal pH found to be 6.5, most cello‐oligosaccharides and xylo‐oligosaccharides as well as the majority of monosaccharides were completely consumed after 40 h, while the lignin‐derived products, organic acids, decomposed and dehydrated compounds required 72 h to be fermented. Overall, it was found that most of the water‐soluble lignocellulosic hydrolyzates were successfully transformed into acetic acid, leading to a high carbon conversion efficiency of 84.9%.

CONCLUSION

Biomass‐derived compounds from hot‐compressed water treatment were efficiently converted to acetic acid, a valuable intermediate for further biotechnological production of chemicals and materials to substitute fossil‐derived ones. © 2015 Society of Chemical Industry
Fused Heterocycles: Synthesis and Antitubercular Activity of Novel 6‐Substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)H‐imidazo[1,2‐a]pyridine
Authors: Abhale Yogita K. , Deshmukh Keshav K. , Sasane Amit V. , Chavan Abhijit P. , Mhaske Pravin C.
Published: March 2015

A series of 6‐substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)H‐imidazo[1,2‐a]pyridine derivatives 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l is described. The antitubercular activity of the synthesized compounds was determined against Mycobacterium smegmatis MC2 155 strain. From the activity result, it was found that the phenyl or 4‐fluorophenyl group at 2 position of thiazole nucleus and bromo substituent at 6 position of imidazo[1,2‐a]pyridine showed good antitubercular activity.
Alcoholic fermentation of Saccharomyces cerevisiae, Pichia stipitis and Zymomonas mobilis in the presence of inhibitory compounds and seawater
Authors: Gonçalves Fabiano Avelino , Santos Everaldo Silvino dos , de Macedo Gorete Ribeiro
Published: March 2015

Production of cellulosic ethanol and holocellulosic ethanol from vegetable or microbial biomass starts with a hydrolysate containing compounds which may produce negative effects in the enzymatic hydrolysis and fermentation stages due to the need of pretreatment of the materials. In this way, the simultaneous presence of hydroxymethylfurfural (HMF), furfural, acetic acid, levulinic acid, and formic acid in different concentrations was tested in the fermentation using Saccharomyces cerevisiae, Pichia stipitis, and Zymomonas mobilis. The substitution of freshwater by seawater in the culture medium was also analyzed. Thus, inhibitory effects were stronger in the fermentation using P. stipitis, followed by Z. mobilis and S. cerevisiae. Formic acid and acetic acid presented more significant effects among the inhibitory compounds, followed by HMF, furfural and levulinic acid. Fermentation performed in culture medium with seawater showed promising results, especially in the ethanol yield using S. cerevisiae (0.50 g ethanol/g glucose) and Z. mobilis (0.49 g ethanol/g glucose). Whereas the production of cellulosic ethanol and holocellulosic ethanol are in early stages of development on an industrial scale, and that the availability and use of freshwater may cause socio‐environmental problems for expansion of ethanol production, the use of seawater appears as an alternative to mitigate this problem.