bluuebunny/crossref_metadata_2025 huggingface dataset:
PELATIHAN EDUKATOR SEBAYA SEBAGAI UPAYA PENCEGAHAN KOMPONEN SINDROM METABOLIK PADA REMAJA DI KABUPATEN SOPPENG
Authors: Jafar Nurhaedar , Kurniati Yessy , Indriasari Rahayu , Syam Aminuddin , Arundhana Andi Imam
Published: July 2020

Peer Educator Training as an Effort to Prevent Components of Metabolic Syndrome in Adolescents  of Soppeng DistrictAbstract. Increased incidence of obesity can trigger the occurrence of Metabolic Syndrome (BC) in adolescents. This activity aims to carry out prevention of SM components in adolescents through peer educator training in Soppeng District. This activity was carried out with a training method that was packaged in providing education about the components of the SM and its prevention and demonstration about the assessment of nutritional status in adolescents. This activity can increase the knowledge of the target audience in the good category by 46%. The activities carried out are quite effective in increasing peer educator knowledge about the components of SM and its prevention in adolescentsKeywords: Obesity, metabolic syndrome, adolescents, peers, school.Abstrak. Kejadian obesitas yang meningkat dapat memicu terjadinya Sindrom Metabolik (SM) pada remaja. Kegiatan ini bertujuan untuk melakukan pencegahan komponen SM pada remaja melalui pelatihan edukator sebaya di Kabupaten Soppeng. Kegiatan ini dilakukan dengan metode pelatihan yang dikemas dalam pemberian edukasi tentang komponen SM dan pencegahannya dan demonstrasi tentang penilaian status gizi pada remaja. Kegiatan ini dapat meningkatkan pengetahuan khalayak sasaran dalam kategori baik sebesar 46%. Kegiatan yang dilakukan cukup efektif untuk meningkatkan pengetahuan edukator sebaya tentang komponen SM dan pencegahannya pada remajaKata Kunci: Obesitas, sindrom metabolik, remaja, sebaya, sekolah.
PELATIHAN E-LEARNING UNTUK MENGINTEGRASIKAN TIK DALAM PEMBELAJARAN BAGI GURU-GURU SMA
Authors: Rahmi Ulfia , Hidayati Abna , Azrul Azrul
Published: July 2020

The Training of E-Learning as ICT Integration in Instructional for Senior High School TeachersAbstract. Schools have supporting facilities for implementing e-learning such as computer laboratories, internet networks, wireless access points, and microtia routers. However, the teachers and the school are not ready from the side of human resources. In other words, the school needs training and workshops for teachers to optimize the use of ICT in learning. The purpose of this activity is to train SMA N 4 Kota Pariaman teachers to prepare e-learning to integrate ICT in the learning process. This activity involved all of the 4 SMA N Pariaman teachers in a number of stages, namely a) introduction to the concepts of e-learning and LMS, b) workshops managing LMS, and c) simulations of e-learning applications that had been prepared by each teacher. The results of this training activity are a) the teachers have been able to design learning materials and activities in e-learning and produce learning material packages, b) the teacher readiness in integrating ICT in learning is increasingly increasing, and c) the school readiness to create smart classes with the application of e-learning.Keywords: e-learning, integrate ICT, LMS, teachersAbstrak.Sekolah-sekolah telah memiliki fasilitas pendukung untuk pelaksanaan e-learning seperi laboratorium komputer, jaringan internet, wireless access point, dan microtic router. Namun guru dan pihak sekolah belum siap dari sisi sumberdaya manusia. Sederhananya, pihak sekolah membutuhkan pelatihan dan workshop bagi guru-guru untuk mengoptimalkan penggunaan TIK dalam pembelajaran. Tujuan kegiatan ini adalah melatih guru-guru SMA N 4 Kota Pariaman untuk mempersiapkan e-learning dapat mengintegrasikan TIK dalam proses pembelajaran. Kegiatan ini melibatkan seluruh guru SMA N 4 Kota Pariaman dengan tiga tahap, yaitu a) pengenalan konsep e-learning dan LMS, b) workshop mengelola LMS, dan c) simulasi aplikasi e-learning yang telah disiapkan untuk masing-masing guru. Hasil kegiatan pelatihan ini adalah a) guru telah mampu merancang materi dan aktifitas belajar di e-learning dan menghasilkan paket materi pembelajaran, b) kesiapan guru dalam mengintegrasikan TIK dalam pemebelajaran semangkin meningkat, dan c) kesiapan sekolah untuk menciptakan smart class dengan penerapan e-learning.Kata Kunci: e-learning, integrasi TIK, LMS, guru
UPAYA OPTIMALISASI PRAKTIK DIGITAL MARKETING UNTUK MENINGKATKAN HASIL PENJUALAN PRODUK WARGA BINAAN LEMBAGA PEMASYARAKATAN
Authors: Melati Inaya Sari , Margunani Margunani , Mudrikah Saringatun , Pitaloka Lola Kurnia
Published: July 2020

Optimization of Digital Marketing Practices to Improve Product Sales of Inamtes in the Productive PrisonAbstract. Productive prisons are prisons that are not only a place for guiding inmates (prisoners) in a conventional manner, but can also be a means to encourage the production of a good quality products, therefore productive activities in prisons can be a support for fostering prisoners. In productive prisons, inmates are taught to grow crops, raise livestock to gardening. Lapas Terbuka Kendal, one of productive prisons in Central Java, is currently only filled with 23 inmates who are fostered by the independence of various production activities, namely the agriculture, fisheries and animal husbandry sectors. The results of Lapas Terbuka Kendal production activities can be said to be quite good. Even marketing has been done well, one of them through the website. But unfortunately the existing marketing did not produce maximum results in sales. This is evaluated and resolved in the community service performed. The digital marketing training is a solution given. All officers were enthusiastic in actively participating during the training. By this training, it is expected they could maximize the digital marketing implementation to boost the sales.Keyword: Digital marketing, productive prison, prisoners, production activities, sales.Abstrak. Lembaga pemasyarakatan (Lapas) produktif merupakan Lapas yang tidak hanya menjadi tempat pembinaan narapidana (warga binaan) secara konvensional, tetapi juga dapat menjadi salah satu sarana untuk mendorong dihasilkannya produk-produk berkualitas, oleh karenanya kegiatan produktif di lapas bisa menjadi penunjang bagi pembinaan terhadap warga Warga Binaan Pemasyarakatan (WBP). WBP diajarkan bercocok tanam, beternak hingga berkebun di Lapas Terbuka. Lapas Terbuka Kendal, salah satu Lapas Produktif di Jawa Tengah, saat ini terisi sebanyak 23 warga binaan yang dibina kemandirian berbagai macam kegiatan produksi yaitu sektor pertanian, perikanan dan peternakan. Hasil kegiatan menunjukkan produksi Lapas Terbuka Kendal dapat dikatakan cukup bagus. Bahkan pemasaran pun sudah dilakukan dengan baik, salah satunya melalui website. Namun sayangnya pemasaran yang ada ternyata tidak membuahkan hasil yang maksimal dalam penjualan. Hal tersebut yang dievaluasi dan dipecahkan pada pengabdian yang dilakukan. Pelatihan pemasaran digital menjadi solusi yang diberikan pada pengabdian ini. Pelaksanaan kegiatan berjalan lancar, seluruh petugas Lapas antusias dalam mengikuti pelatihan. Kegiatan ini diharapkan mereka mampu memaksimalkan fungsi pemasaran digital untuk meningkatkan penjualan.Kata Kunci: Digitalisasi, pemasaran, kegiatan produksi, peningkatan penjualan.
Analisis Risiko Pembiayaan Bank Syariah
Authors: Ilyas Rahmat
Published: July 2020

Financing or financing is funding provided by one party to another party to support the planned investment, whether done alone or in an institution. Risk in the banking context is a potential event, both predictable and unpredictable that has a negative impact on bank income and capital. The main reason for the occurrence of credit risk is that banks are too easy to lend or invest because they are too required to take advantage of excess liquidity, so that credit assessments are less careful in anticipating various possible business risks that they finance. Risk management is needed to identify, measure and control various types of risk, because it becomes a very basic tool to support the sustainability of the bank's business. The type of risk management that is closely related to the role of DPS is reputation risk, which in turn has an impact on displaced commercial risk, such as liquidity risk and other risks. The function and role of DPS in Islamic banks has strong relevance to the risk management of Islamic banking, namely reputation risk, which in turn impacts other risks such as liquidity risk.
Aligning US Spending Priorities Using the Health Impact Pyramid Lens
Authors: McCullough J. Mac , Leider Jonathon P. , Resnick Beth , Bishai David
Published: July 2020

Thomas Frieden’s “health impact pyramid” presents a hierarchy in which the wide base of the pyramid of socioeconomic factors at a population level has more impact on the health of the public than do individually focused interventions at the pyramid’s top.

From this pyramid perspective, the US spending priorities are misaligned, as expenses targeted at public health and socioeconomic factors are far outstripped by spending on individual health care services at the top of the pyramid. The nation’s ongoing debate on health care reform continues to focus on access to individual health care services, despite evidence demonstrating the health impacts of population-level efforts at the base of the pyramid and the synergistic health impacts of health and social service collaboration.

We examine the need for improved systems alignment through the lens of the health impact pyramid. We catalog the types of misalignments and their social, political, and systems genesis. We identify promising opportunities to realign US health spending toward the socioeconomic factor base of the health impact pyramid and emphasize the need to integrate and align public health, social services, and medical care in the United States.
Associations Between Cross-Sector Partnerships and Local Health Department Participation in Population-Based Activities to Prevent Mental Health Conditions
Authors: Nelson Katherine L.
Published: July 2020

Objectives. To describe partnerships between US local health departments (LHDs) and community organizations and assess the relationship between the types of activities performed in these partnerships and LHD engagement in population-based activities to prevent mental health conditions.

Methods. Data were derived from 457 LHDs that responded to module 1 of the 2016 Profile Study conducted by the National Association of County and City Health Officials. These data were used to assess the presence of partnerships with community organizations and examine associations between the types of activities performed in such partnerships and LHDs’ participation in population-based activities to prevent mental health conditions.

Results. LHDs had higher odds of participating in population-based activities to prevent mental health conditions if they shared personnel or resources or had written agreements with mental health or substance use disorder providers, held regularly scheduled meetings with hospitals, or shared personnel or resources with community health centers. Odds were reduced if they exchanged information with community health centers or shared personnel or resources with faith-based organizations.

Conclusions. This study offers an improved understanding of how the types of activities performed in cross-sector partnerships affect LHDs’ participation in population-based activities to prevent mental health conditions, which is important as public policies, programs, and funding initiatives continue to encourage cross-sector partnership building.
Linking Health and Housing Data to Create a Sustainable Cross-Sector Partnership
Authors: Laurent Amy A. , Matheson Alastair , Escudero Katie , Lazaga Andria
Published: July 2020

In response to the growing regional (and national) focus on health and housing intersections, two public housing authorities (PHAs) in Washington—the King County Housing Authority and the Seattle Housing Authority—joined with Public Health–Seattle & King County to form the Housing and Health (H&H) partnership in 2016. H&H linked Medicaid health claims with PHA administrative data to create a sustainable public-facing dashboard that informs health and housing stakeholders such as an Accountable Community of Health (a governing body that oversees local Medicaid transformation projects), managed care organizations, and PHAs, allowing insights into the low-income communities they serve.
Universal Screening of Social Determinants of Health at a Large US Academic Medical Center, 2018
Authors: Meyer Dodi , Lerner Eva , Phillips Alex , Zumwalt Katarina
Published: July 2020

Universal screenings for social determinants of health (SDOH) are feasible at the health system level and enable institutions to identify unmet social needs that would otherwise go undiscovered. NewYork-Presbyterian Hospital implemented SDOH screenings together with clinical screenings in four outpatient primary care sites. Aligning SDOH screening with clinical screening was crucial for establishing provider buy-in and ensuring sustainability of screening for SDOH. Despite some challenges, universal screening for SDOH has allowed NewYork-Presbyterian Hospital to identify unmet needs to improve population health.
The Growing Divide in the Composition of Public Health Delivery Systems in US Rural and Urban Communities, 2014–2018
Authors: Owsley Kelsey M. , Hamer Mika K. , Mays Glen P.
Published: July 2020

Objectives. To examine changes in the scope of activity and organizational composition of public health delivery systems serving rural and urban US communities between 2014 and 2018.

Methods. We used data from the National Longitudinal Survey of Public Health Systems to measure the implementation of recommended public health activities and the network of organizations contributing to these activities in a nationally representative cohort of US communities. We used multivariable regression models to test for rural–urban differences between 2014 and 2018.

Results. The scope of recommended activities implemented in rural areas declined by 3.4 percentage points between 2014 and 2018, whereas it increased by 1.4 percentage points in urban areas. The rural–urban disparity in scope of activities grew by a total of 4.8 percentage points (P < .05) over this time. The disparity in network density grew by 2.3 percentage points (P < .05).

Conclusions. Urban public health systems have enhanced their scope of activities and organizational networks since 2014, whereas rural systems have lost capacity. These trends suggest that system improvement initiatives have had uneven success, and they may contribute to growing rural–urban disparities in population health status.
Endoscopic Carpal Tunnel Release
Authors: Deune E. Gene
Published: July 2020

Background:

With the 1-portal technique for endoscopic carpal tunnel release, the incision is less tender and patients have less postoperative need for analgesics, and return to activities of daily living and work seems to be earlier. The literature also confirms an earlier return to work. Surgical time can be shorter as less time is spent in making and closing the incision.

Description:

The 1-portal technique, as described by Agee et al., is performed with the patient under general anesthesia, supplemented with only a small amount of local anesthesia in the beginning to blunt the pain response during the incision. Then, once the patient is fully anesthetized, the endoscope is inserted, and the carpal ligament is visualized and incised. The incision is closed and the dressing is applied.

Alternatives:

Another surgical alternative is open carpal tunnel release. Nonsurgical alternatives include corticosteroid injection, splinting, nonsteroidal anti-inflammatory drugs, and ergonomics.

Rationale:

The incision is smaller and less painful than the incision utilized during open carpal tunnel release. There is less need for analgesia. Unlike the incision utilized during open carpal tunnel release, the incision in this procedure is not made in a weight-bearing surface of the hand and generally is not firm and tender. Studies also show an earlier return to work with this technique. The endoscopic technique is only for a primary release. Surgical intervention for recurrent carpal tunnel syndrome needs to be performed with the open technique. Because of the need for deep sedation, only patients who are healthy enough for general sedation are candidates for the 1-portal technique. The risk of nerve injury with this technique is higher than with open carpal tunnel release.

Expected Outcomes:

Generally, the patient will have very rapid resolution of the preoperative paresthesia. The incision typically heals very well; however, when closing the 1.5-cm incision with skin glue and Steri-Strips (3M), there may be cases of delayed wound-healing if the patient is overly physically active in the first 2 weeks after the procedure.

Important Tips:

Make sure that the endoscope is properly set up and that the patient is supine and the arm is abducted 90° at the shoulder with the hand and forearm fully supinated. Seating of the surgeon and assistant(s) and placement of the monitor are important.

Make sure that the patient is fully anesthetized, particularly when the endoscope is being used. If the patient moves during the endoscopic incision of the ligament, other structures (i.e., vessels, nerves, and tendons) could be injured.

Difficulty with the insertion of the scope can result in injuries. The carpal ligament must be visualized with the scope prior to any attempts at cutting the ligament. Convert to an open procedure if there are any difficulties with endoscope insertion or visualizing the carpal ligament.
The Canary in the Coal Mine: Testate Amoebae Record Anthropogenic Impacts in Sediments of Oligotrophic Lake George, NY, USA
Authors: Kornecki Krystyna M. , Schuler Matthew S. , Katz Miraim E. , Relyea Rick A. , McCarthy Francine M. G. , Schaller Morgan F. , Gillikin David P. , Stager J. Curt , Boylen Chuck W. , Eichler Lawrence W. , Nierzwicki-Bauer Sandra A.
Published: July 2020

Lake George (NY) is surrounded by Forever Wild Forest in the Adirondack Park and has a Class AA Special water quality rating, yet lake monitoring has revealed increasing anthropogenic impacts from salt and nutrient loading over the past 30 years. To reconstruct anthropogenic influence on the lake (e.g., salt loading, eutrophication, climate warming), we characterized modern stable isotopes and testate amoeba and diatom assemblages in surface sediments from 33 lake-wide sites and compared their variability to 36 years of water-quality data.

Linear regression analyses support testate amoebae as rapid responders and recorders of environmental change because taxa are strongly correlated with percent change of important water quality parameters. Our assessment indicates that: 1) Netzelia gramen is associated with aquatic plants and filamentous algae, making them a valuable aquatic plant/alga indicator, which is supported by the co-occurrence of the diatom Cocconeis spp.; 2) difflugids are generally good indicators of eutrophication, except for Difflugia protaeiformis; and 3) seasonal differences in water quality trends are reflected in the fossil record on decadal time scales. We show that testate amoebae are highly sensitive to small environmental changes in an oligotrophic lake and exhibit established relationships from eutrophic and mesotrophic lakes as well as new, likely oligotrophic-specific correlations. Correlation coefficients of water quality variables and strains within a species also illustrate gradational relationships, suggesting testate amoebae exhibit ecophenotypic plasticity. Diatom and testate amoeba assemblages categorize modern lakebed sites into four subgroups: 1) benthic macrophyte; 2) high nutrient; 3) high alkalinity; and 4) salt loading assemblages.
Turrispirillina Karasikensis (n. sp.) and Turrispirillina Pervesleri (n. sp.) Associated with Large Sponges on the Gakkel Ridge (Arctic Ocean)
Authors: Bukenberger Patrick , Heinz Petra , Wollenburg Jutta E.
Published: July 2020

Here we describe two new species of the genus Turrispirillina associated with large siliceous sponge reefs on the Karasik Seamount (Gakkel Ridge, Arctic Ocean). Careful analysis of Rose Bengal-stained samples and observations on untreated frozen sponge material revealed both species live exclusively inside siliceous sponges of the genus Geodia. More detailed information on the intra-sponge habitat was obtained from untreated frozen sponge material that showed both Turrispirillina species attach themselves to the large megascelere spicules that stabilize the choanoflagellates-harbouring subcortical crypts situated under the thick sponge cortex. Unstained specimens of both species were very abundant in the sediments surrounding the sponge. The number of Rose Bengal-stained specimens in each sample obviously depended on the penetration of a Geodia sponge, likely also the exact position of penetration with respect to the sponge. As sexual and asexual generations are observed in both taxa and sampling took place in autumn, opportunistic behavior with rapid reproduction following the spring bloom may determine the standing stock of both species. These are the first Arctic Turrispirillina species described with pseudospines.
Sensitivity of Benthic Foraminifera to Carbon Flux in the Western Tropical Pacific Ocean
Authors: Billups Katharina , Eichler Patricia P. B. , Vital Helenice
Published: July 2020

We investigated benthic foraminiferal species as tracers for carbon export flux in the Indo-Pacific warm pool (International Ocean Discovery Program Expedition 363). In core tops, the distribution of lower bathyal and upper abyssal species can be separated into two distinct groups. Foraminifera belonging to the high carbon flux (>3.5 g C m−2 year−1), ‘warm’ (>3.5°C) group are Bolivina robusta, Bulimina aculeata, Globobulimina pacifica, Hoeglundina elegans, Laticarinina pauperata, and Cibicidoides pachyderma. The lower carbon flux, ‘cold’ group includes Oridorsalis umbontus, Uvigerina bifurcata, and Planulina wuellerstorfi. An index based on the percent ‘warm’ assemblage with respect to the total ‘warm’ plus ‘cold’ species in core-top samples correlates significantly with carbon flux (r = 0.91, P = 0.0007) and modern bottom water temperatures (r = 0.94, P = 0.0002). When applied to down-core species abundances based on core catchers spanning the late Miocene through Pleistocene, we observed that sites from the northwestern Australian margin show marked changes in the ‘warm’ index, suggesting a large paleoenvironmental signal in this dynamic region. At Papua New Guinea, down-core abundances of the ‘warm’ group are highest (>80%), consistent with high organic matter input via the Sepik River. At the deeper of the two sites, down-slope movement in this tectonically unstable region may have contributed to organic matter input. At Manus Basin, the ‘warm’ species abundances are also relatively high and covary with the percent abundance of Uvigerina proboscidea, providing further evidence for the use of this index as a tracer for carbon flux. Overall, this study contributes evidence for the relationship between benthic foraminiferal assemblages and carbon export flux in the Indo-Pacific warm pool, suggesting that the ‘warm’ index can be used as a tracer for paleoproductivity.
Glomulina oculus, New Calcareous Foraminiferal Species from the High Arctic: A Potential Indicator of a Nearby Marine-Terminating Glacier
Authors: Jennings Anne E. , Seidenkrantz Marit-Solveig , Knudsen Karen Luise
Published: July 2020

A new calcareous Arctic foraminiferal species, Glomulina oculus n. sp., belonging to the suborder Miliolina has been observed in surface samples from northern Nares Strait and Petermann Fjord, NW Greenland, and off Zachariae Isbrae, NE Greenland, as well as in early Holocene sediments from the northern Baffin Bay region and on the NE Greenland shelf. In some samples, this new porcelaneous species makes up a significant fraction of the foraminiferal assemblage, particularly in samples with a relatively large sand content, and we suggest that this species is indicative of an Arctic environment with marine-terminating glaciers. Yet, further studies are needed to ascertain its full habitat range.
Association between levels of tumor-infiltrating lymphocytes in different subtypes of primary breast tumors and prognostic outcomes: A meta-analysis
Authors: He Lin , Wang Yaling , Wu Qian , Song Yuhua , Ma Xuezhen , Zhang Biyuan , Wang Haiji , Huang Yong
Published: July 2020

Background: To investigate the impact of the elevation of tumor-infiltrating lymphocytes (TILs) in different molecular subtypes of primary breast cancer, i.e. each 10% increment of TILs and high-level TILs (TILs≥50%) in tumor, on overall survival (OS) and pathological complete response (pCR) and to compare the presentation of high-level TILs across these molecular subtypes. Methods: Citation retrieval was performed in the PubMed, Cochrane Library, Embase and Web of Science databases. All statistical calculations were performed by the software of StataSE version 12.0. Results: Twenty-two eligible clinical trials including 15676 unique patients were included for meta-analysis. Each 10% increment of TILs significantly improved OS in human epidermal growth factor receptor 2 (HER2)-overexpression (pooled Hazard ratio (HR), 0.92; 95% CI, 0.89-0.95) and triple-negative (TN) (pooled HR, 0.90; 95% CI, 0.89-0.92) breast tumors but not in luminal tumor subtype (pooled HR, 1.06; 95% CI, 0.99-1.13). It was also associated with an increased pCR rate in breast cancers (pooled Odds ratio (OR), 1.27; 95% CI, 1.19-13.5). High-level TILs were significantly related with a higher pCR rate (pooled OR, 2.73; 95% CI, 2.40-3.01) than low-level TILs. The HER2-amplified (pooled OR, 3.14; 95% CI, 1.95-5.06) and TN (pooled OR, 4.09; 95% CI, 2.71-6.19) phenotypes of breast cancers expressed significantly more high-level TILs than the luminal tumor subtype, although the presentation of those between the former two subsets was not significantly different (pooled OR, 1.30; 95%CI, 0.83-2.04). Conclusions: The elevation of TILs in breast tumors predicts favorable prognostic outcomes, particularly in the HER2-overexpression and TN subtypes.
Analysis of long non-coding RNA expression profiles in high-glucose treated vascular endothelial cells
Authors: Xu Erqin , Hu Xiaolei , Li Xiaoli , Jin Guoxi , Zhuang Langen , Wang Qiong , Pei Xiaoyan
Published: July 2020

Background: Diabetes mellitus is often associated with microvascular and macrovascular lesions, and hyperglycemia-induced vascular endothelial cell damage is a key factor. Methods： We investigated long non-coding RNAs (lncRNAs) and mRNAs that are affected by hyperglycemia-induced damage using human umbilical vein endothelial cells (HUVECs) as a model. HUVECs were cultured under high (25 mmol/L)or normal normal (5 mmol/L) glucose conditions for 6 d, and then lncRNAs and protein-coding transcripts were profiled by RNA-seq. Results： Among 40,379 lncRNAs screened, 214 were upregulated (log2 [fold-change] > 1, FDR < 0.05) and 197 were downregulated (log2 [fold-change] < −1, FDR < 0.05) in response to high-glucose. Furthermore, among 28,431 protein-coding genes screened, 778 were upregulated and 998 were downregulated. A total of 945 lncRNA/mRNA pairs were identified, including 126 differentially expressed lncRNAs predicted to target 201 mRNAs, among which 26 were cis-regulatory interactions. The corresponding lncRNA-mRNA network was composed of 354 lncRNA nodes, 1,167 mRNA nodes and 9,735 edges. Dozens of lncRNAs with high degree may play important roles in high-glucose-induced HUVEC damage, including ENST00000600527, NONHSAT037576.2, NONHSAT135706.2, ENST00000602127, NONHSAT200243.1, NONHSAT217282.1, NONHSAT176260.1, NONHSAT199075.1, NONHSAT067063.2, NONHSAT058417.2. Conclusion： These observations may provide novel insights into the regulatory molecules and pathways of hyperglycemia-related endothelial dysfunction in diabetes-associated vascular disease.
Mortality at the Pediatric Emergency Unit of the Mohammed VI Teaching Hospital of Marrakech
Authors: Lahmini Widad , bourrous mounir
Published: July 2020

Background : The death of a child at the emergency ward is one of the most difficult problems that the clinicians of these wards have to deal with. In our country the published data concerning the causes and the factors related to pediatric mortality especially in the pediatric emergency wards is very rare. This study aimed to study the epidemiology of the pediatric mortality in the pediatric emergency department (PED), to determine its rate and identify its most frequent causes. Methods : It is a retrospective and descriptive study, over five years (1st January 2012 and 31st December 2016) including all children aged from 0 to 15 years old who died at the PED in the Mohamed VI Hospital in Marrakech. Results : During the period of the study a total of 172.691 patients presented to the PED, among which 628 died (pediatric mortality rate : 3.63%). The masculine gender was predominant (n=383) with a gender ratio of 1.59. Two-thirds of the patients died in the first 24 hours (n=421). The median of time from admission to death was around 12 hours. Majority of the deceased children (n=471, 75%) were from a low socioeconomic status. The most frequent cause of admissions for deceased patients in the PED was respiratory distress (n=296, 47%) followed by neurological disorders (n=70, 11%). Neonatal mortality (≤ 1 month of age) was predominant (n=472, 75.1%), followed by postnatal mortality (1 month to 1 year old) (n=73, 11.6%). The most frequent causes of pediatric mortality, whatever the age range, were dominated by neonatal pathologies (n=391, 62.3%), followed by infecious causes bronchopulmonary infections included (n=49, 7.7%), birth deformities (n=46, 7.3%) while traumas were merely at 0.9% (n=6). The most frequent causes of neonatal mortality were neonatal infections (n=152, 32.2%) and prematurity (n=115, 24.4%). Conclusion : Our data once again underline the crucial importance of prevention. This requires correct follow-up of the pregnancies, an adequate assistance of births, and perfecting healthcare provision to newborns in order to attain proper assistance.
How to promote exclusive breastfeeding in Ireland: a qualitative study on views of Chinese immigrant mothers
Authors: Chen Haoyue , Zhou Qianling , Cassidy Tanya M. , Younger Katherine M. , Shen Siao , Kearney John M.
Published: July 2020

Background

The exclusive breastfeeding rate in Ireland is very low with extremely slow annual growth. The population of immigrants in Ireland is increasing. Improving exclusive breastfeeding practice among immigrants may contribute to the overall improvement of exclusive breastfeeding rates in Ireland. This study was conducted to elicit recommendations on improving exclusive breastfeeding rate for six months among Chinese immigrants in Ireland.

Methods

Fourteen semi-structured in-depth individual interviews were conducted with Chinese immigrant mothers resident in Ireland, who breastfed exclusively for four to six months.

Results

Themes generated from thematic content analyses were 1) recommendation for mothers: improve self-intention to breastfeed exclusively and self-efficacy, be financially secure before pregnancy, and obtain breastfeeding information proactively. 2) Recommendation for family members, employers and colleagues, and health care professionals: family members should offer sufficient support. Employers should provide hygienic places for breastmilk storage, and set up breastfeeding rooms and nurseries. Irish hospitals need to advocate exclusive breastfeeding, recruit and train multilingual health care professionals, and combine breastfeeding knowledge with practice in the prenatal education. 3) Recommendation for the government: set up breastfeeding rooms and dedicated rooms for breastfeeding groups, and increase the publicity and visibility of breastfeeding in multiple languages. An independent welfare policy for immigrants was also recommended.

Conclusions

The key findings emerging from this study may be considered in the development of breastfeeding promotion strategies in Ireland. Our findings could also have implications for other English-speaking countries with low rates of exclusive breastfeeding.
A family of partial-linear single-index models for analyzing complex environmental exposures with continuous, categorical, time-to-event, and longitudinal health outcomes
Authors: Wang Yuyan , Wu Yinxiang , Jacobson Melanie H. , Lee Myeonggyun , Jin Peng , Trasande Leonardo , Liu Mengling
Published: July 2020

Background: Statistical methods to study the joint effects of environmental factors are of great importance to understand the impact of correlated exposures that may act synergistically or antagonistically on health outcomes. This study proposes a family of statistical models under a unified partial-linear single-index (PLSI) modeling framework, to assess the joint effects of environmental factors for continuous, categorical, time-to-event, and longitudinal outcomes. All PLSI models consist of a linear combination of exposures into a single index for practical interpretability of relative direction and importance, and a nonparametric link function for modeling flexibility. Methods: We presented PLSI linear regression and PLSI quantile regression for continuous outcome, PLSI generalized linear regression for categorical outcome, PLSI proportional hazards model for time-to-event outcome, and PLSI mixed-effects model for longitudinal outcome. These models were demonstrated using a dataset of 800 subjects from NHANES 2003-2004 survey including 8 environmental factors. Serum triglyceride concentration was analyzed as a continuous outcome and then dichotomized as a binary outcome. Simulations were conducted to demonstrate the PLSI proportional hazards model and PLSI mixed-effects model. The performance of PLSI models was compared with their counterpart parametric models. Results: PLSI linear, quantile, and logistic regressions showed similar results that the 8 environmental factors had both positive and negative associations with triglycerides, with a-Tocopherol having the most positive and trans-b-carotene the most negative association. For the time-to-event and longitudinal settings, simulations showed that PLSI models could correctly identify directions and relative importance for the 8 environmental factors. Compared with parametric models, PLSI models got similar results when the link function was close to linear, but clearly outperformed in simulations with nonlinear effects. Conclusions: We presented a unified family of PLSI models to assess the joint effects of exposures on four commonly-used types of outcomes in environmental research, and demonstrated their modeling flexibility and effectiveness, especially for studying environmental factors with mixed directional effects and/or nonlinear effects. Our study has expanded the analytical toolbox for investigating the complex effects of environmental factors. A practical contribution also included a coherent algorithm for all proposed PLSI models with R codes available.
Short Term Changes in Anterior Segment and Retina After Small Incision Lenticule Extraction
Authors: Chen Yanwei , Liao Huaping , Sun Yue , Shen Xi
Published: July 2020

Purpose: To analyze changes of the anterior segment and retina after small incision lenticule extraction (SMILE) in the short term.Methods: Myopia patients scheduled for SMILE were recruited in Ruijin Hospital, Shanghai, China. Basic information of patients such as age, gender, and refractive errors was recorded. Ocular measurements were taken before surgery, 1 day and 1 week after surgery, including axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), white to white (WTW), pupil diameter (PD), macular thickness (MT), ganglion cell layer thickness (GCL), retinal nerve fiber layer thickness (RNFL), choroidal thickness (CT), macular vessel density, optic disc vessel density. Results of postoperative were compared to baseline, respectively, with paired student t test, and the results were considered statistically significant when p<0.05. Correlations between sphere and changes of ACD (𝜟ACD) and LT (𝜟LT) were analyzed with the Pearson correlation coefficient.Results: 61 eyes of 31 patients were selected for this study. AL, CCT, ACD, and PD postoperative were significantly reduced (p<0.05), while LT was thickened after surgery (p<0.05). MT at the fovea decreased on 1 day and 1 week after surgery (p<0.05). GCL was no statistical changes after surgery. RNFL was unchanged 1 day after surgery, but the inferior sector was thickened 1 week after surgery. CT was observed thicker at fovea 1 day after surgery and 1.0mm from the fovea in nasal 1 week after surgery. Macular vessel density was significantly decreased on 1 day after surgery and most recovered in 1 week. Optic disc vessel density decreased at the peripapillary part on 1 day after surgery and recovered in 1 week. 𝜟ACD and 𝜟LT were found no significant correlation on 1 day after surgery. 𝜟ACD was negatively correlated with 𝜟LT and sphere on 1 week after surgery (r=-0.847, p<0.000; r=-0.398, p=0.002). 𝜟LT was positively correlated with the sphere on 1 week after surgery (r=0.256, p=0.048).Conclusion: Anterior segment was the most influenced while the retina was also impacted in MT, RNFL, CT, macular vessel density, and peripapillary vessel density.
A Nomogram based on a Patient-reported Outcomes Measure: Predicting the Risk of Readmission for Patients with Chronic Heart Failure
Authors: Han Qiang , Ren Jia , Tian Jing , Yang Hong , Zhang Qing , Wang Ruoya , Zhao Jinghua , Han Linai , Li Chenhao , Yan Jingjing , Wang Ke , Zheng Chu , Han Qinghua , Zhang Yanbo
Published: July 2020

Background

Health-related quality of life, evaluated by a patient-reported outcomes measure, is an important prognostic marker in patients with chronic heart failure. This study aimed to use PROM to establish an effective readmission nomogram for chronic heart failure.

Methods

Using patient-reported outcomes measure as a measurement tool, we conducted a readmission nomogram for chronic heart failure on a prospective observational study comprising 454 patients with chronic heart failure hospitalized between May 2017 to January 2020. Concordance index and calibration curve were used to evaluate the discriminative ability and predictive accuracy of the nomogram. A bootstrap resampling method was used for internal validation of results.

Results

The median follow-up period in the study was 372 days. After a final COX regression analysis, the gender, income, health care, appetite-sleep, anxiety, depression, paranoia, support, and independence were identified and included in the nomogram. The nomogram showed moderate discrimination, with concordance index of 0.737 (95% CI 0.673-0.800). The calibration curves for the probability of readmission for patients with chronic heart failure showed high consistency between the probability, as predicted, and the actual probability.

Conclusions

This model offers a platform to assess the risk of readmission for different populations with CHF and can assist clinicians with personalized treatment recommendations.
Analysis of Operation Procedure and Effect for Emergency Surgery in General Hospital During Novel Coronavirus Pneumonia Period
Authors: Liu Yuchen , Wang Minggang , Shen Yingmo , Chen Jie
Published: July 2020

Background Novel coronavirus pneumonia(NCP) outbreak in Wuhan, China in early 2020, resulted in over 80 thousand infections in China. At present, NCP has an explosive growth in the world. Surgeons could refuse selective operation during the outbreak, but they must face the emergency operation. We hope to avoid the spread of NCP while ensuring efficient treatment of emergency cases. Methods The data of patients with incarcerated hernia admitted to Beijing Chaoyang Hospital during NCP epidemic were analyzed and compared with those in 2019. All cases were divided into NCP group and 2019 group. The operation data and inpatient protection process of emergency cases were analyzed. Result During the NCP epidemic, 17 cases with incarcerated hernia were treated in our department. A Total of 263 cases of the same disease were admitted in 2019. There was no significant difference in age, gender, BMI and hernia type between two groups. No significant difference was observed between the two groups in operation method and hospital stay. The waiting time for emergency operation of NCP group was significantly longer than that of 2019 group (P=0.002). A buffer ward was set up by administrator of hospital during NCP outbreak. Hospitals were divided into "Red area, Yellow area and Green area" artificially, and strict screening consultation system was implemented. There was no case of SARS-nCoV-2 infection in medical staff. ﻿Conclusion It was safe and effective to carry out emergency operation on the premise of screening, protection and isolation during the NCP epidemic. The increased waiting time for operation due to NCP screening did not threaten medical safety of emergency incarcerated hernia patients.
Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC): Does increased intraperitoneal pressure change distribution patterns and penetration depth of doxorubicin in a sheep model?
Authors: Mimouni Myriam , Richard Christophe , Adenot Pierre , Letheule Martine , Tarrade Anne , Sandra Olivier , Dahirel Michèle , Lilin Thomas , Lecuelle Benoit , Gélin Valérie , Cohen Julien , Fauconnier Arnaud , Vialard François , Huchon Cyrille , Chavatte-Palmer Pascale
Published: July 2020

Background:Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) is an innovative treatment against peritoneal carcinomatosis. Doxorubicin is a common intra-venous chemotherapy used for peritoneal carcinomatosis and for PIPAC. This study evaluated the impact of increased PIPAC intraperitoneal pressure on the distribution and cell penetration of doxorubicin in a sheep model.Methods: Doxorubicin was aerosolized using PIPAC into the peritoneal cavity of 6 ewes (pre-alpes breed): N=3 with 12mmHg intraperitoneal pressure (group 1) and N=3 with 20mmHg (group 2). Samples from peritoneum (N=6), ovarian (N=1), omentum (N=1) and caecum (N=1) were collected for each ewe. The number of doxorubicin positive cells was determined using the ratio between doxorubicine fluorescence-positive cell nuclei (DOXO+) over total number of DAPI positive cell nuclei (DAPI+). Penetration depth (μm) was defined as the distance between the luminal surface and the location of the deepest DOXO+ nuclei over the total number of cell nuclei that were stained with DAPI. Penetration depth (μm) was defined as the distance between the luminal surface and the location of the deepest DOXO+ nuclei.Results: DOXO+ nuclei were identified in 87% of samples. All omental samples, directly localized in front of the nebulizer head, had 100% DOXO+ nuclei whereas very few nuclei were DOXO+ for caecum. Distribution patterns were not different between the two groups but penetration depth in ovary and caecum samples was significantly deeper in group 2. Conclusions:This study showed that applying a higher intra-peritoneal pressure during PIPAC treatment leads to a deeper penetration of doxorubicin in ovarian and caecum but does not affect distribution patterns.
Psychometric Properties of the Moral Injury Symptoms Scale among Chinese Health Professionals during the COVID-19 Pandemic
Authors: Wang Zhizhong , Koenig Harold G , Tong Yan , Wen Jing , Sui Mu , Liu Hongyu , Liu Guangtian
Published: July 2020

Aims To assess the psychometric properties of the 10-item Moral Injury Symptoms Scale-Health Professional (MISS-HP) among healthcare professionals in China. Methods: A total of 583 nurses and 2,423 physicians were recruited from across mainland China. An online survey was conducted using the Chinese version of the MISS-HP from March 27 to April 26, 2020 (during the middle of the COVID-19 pandemic). Reliability was assessed by internal consistency reliability and test-retest reliability. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) was performed to determine scale structure. Results: Cronbach’s α of the scale for both samples was acceptable (0.71 for nurses and 0.70 for physicians), as was test-retest reliability ( ICCs for the individual items ranged from 0.41 to 0.74, with 0.77 for the overall scale in physicians). EFA suggested three factors, and the CFA indicated good fit to the data. Convergent validity was demonstrated with the 4-item Expressions of Moral Injury Scale (r=0.45 for physicians, r=0.43 for nurses). Discriminant validity was demonstrated by correlations with burnout and well-being (r=0.34–0.47), and concurrent validity was suggested by correlations with depression and anxiety symptoms (r=0.37–0.45). Known groups validity was indicated by a higher score in those exposed to workplace violence (B=4.16, 95%CI: 3.21-5.10, p<0.001). Conclusion: The MISS-HP demonstrated acceptable reliability and validity in a large sample of physicians and nurses in mainland China, supporting its use as a screening measure for moral injury symptoms among increasingly stressed health professionals in this country during the COVID-19 pandemic.
Nutrient restriction, inducer of yeast meiosis, induces mammalian meiotic initiation
Authors: Zhang Xiaoyu , Gunewardena Sumedha , Wang Ning
Published: July 2020

From yeasts to mammals, the molecular machinery and chromosome structures carrying out meiosis are frequently conserved. However, the signal to initiate meiosis appears divergent: while nutrient restriction induces meiosis in the yeast system, retinoic acid (RA), a chordate morphogen, and its target, Stra8, are necessary but not sufficient to induce meiotic initiation in mammalian germ cells. Here, by using a combination of genetic, transcriptomic, cytologic approaches in mouse primary spermatogonial culture without the support of gonadal somatic cells, we show that nutrient restriction is both necessary and sufficient to robustly induce Spo11-dependent meiotic DNA double strand breaks (DSBs) and Stra8-dependent meiotic gene programs with RA, recapitulating those of early meiosis in vivo. Moreover, distinct network of 11 nutrient restriction-upregulated transcription factor genes was identified, whose expression does not require RA and is associated with early meiosis in vivo. Thus, our study proposes a conserved model, in which nutrient restriction induces meiotic initiation by upregulating key transcriptional factors for meiotic gene programs, and provides an in vitro platform to recapitulate meiotic initiation that will facilitate research and haploid gamete production.