bluuebunny/crossref_metadata_2025 huggingface dataset:
A Critique of Ladd’s ‘Already but not Yet’ View of the Kingdom
Authors: Scholtz Jacob Jan
Published: November 2022

The kingdom of God is an important subject for theology and for a Christian worldview. As one of the most influential theologians of the twentieth century, George Eldon Ladd is arguably the father of the widely held ‘already but not yet’ view of the kingdom. Ladd contends that the kingdom can be both present and future at the same. The key to Ladd’s theory is his definition of the kingdom. If the kingdom can be present and future at the same time, Ladd realises that logically it cannot also be so in the same sense. Therefore, he postulates that Jesus offered a new and unexpected form of the kingdom, arguing that the New Testament radically reinterprets the Old Testament and calling this the mystery of the kingdom. This article critiques Ladd’s definition of the kingdom. The kingdom cannot logically be present and future at the same time. Moreover, Jesus did not offer a new ‘form’ of the kingdom. Regarding the mediatorial kingdom of God, the missing key is the word ‘conditional’
Motivasi Mahasiswa Tahfidz dalam Mengikuti Sima’an Al-Qur’an di IAIN Ponorogo
Authors: Mahmudin Afif Syaiful
Published: November 2022

Sima'an Al-Qur'an is mutual listening and listening to the readings between two or more people, if one person reads then the other listens. This activity is very useful for one's memorization, before attending sima'an, one will prepare juz-juz to be read by adding hours for muraja'ah. Like the Sima'an Al-Qur'an activity which is held at the Ulin-Nuha Mosque every Kliwon Friday by IAIN Ponorogo students. The formulation of the research problem is, how are the students' intrinsic motivation and extrinsic motivation in participating in Sima'an Al-Qur'an activities at the Ulin-Nuha Mosque, State Islamic Institute (IAIN) Ponorogo? To answer this question, the researcher uses a qualitative approach (case study), using analytical methods through reduction, display and conclusion. The data collection techniques used were observation, interviews and documentation, while the researcher was the key instrument. From the results of this study it was found that: (a) Intrinsic motivation of students to follow Sima'an Al-Qur'an every Kliwon Friday at the Ulin-Nuha mosque IAIN Ponorogo because it is to improve academic achievement related to Al-based courses al-Quran and the quality of memorization that is their duty as a memorizer of the Koran. (b) Extrinsic motivation is the encouragement from family and colleagues related to the ability to maintain memorization, the process of academic competition and the existence of learning scholarships.
Problematika Penanggulangan Kenakalan Remaja
Authors: Padli Erwin , Setiawan Aprido Bagus , Taisir Muhammad
Published: November 2022

Penelitian ini bertujuan untuk mengetahui bentuk penanggulangan kenakalan remaja, dan untuk mengetahui problematika penanggulangan kenakalan remaja di Lingkungan Aik Ampat Bawak Gunung Kelurahan Dasan Geres Kecamatan Gerung. Penelitian menggunkan metode penelitian kualitatif dengan pendekatan deskriptif, teknik pengumpulan data dalam penelitian ini adalah observasi, wawancara, dan dokumentasi. Analisis data dengan menggunakan teknik analisis interaktif dengan langkah-langkah reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa, bentuk penanggulangan kenakalan remaja di Lingkungan Aik Ampat Bawak Gunung Kelurahan Dasan Geres Kecamatan Gerung, yakni dengan mengadakan acara yang bersifat positif, mengadakan pengajian umum, melibatkan remaja dalam aktivitas sosial agama, membangun lembaga pendidikan Islam, dan Ikut serta dalam kegiatan-kegiatan remaja masjid. Semua bentuk penanganan di atas merupakan bentuk usaha dari kepala lingkungan, tokoh agama dan tokoh masyarakat yang ada di Lingkungan Aik Ampat Bawak Gunung dalam mencegah terjadinya kenakalan remaja. Adapun problem atau kendala dalam penanggulangan kenakalan remaja di Lingkungan Aik Ampat Bawak Gunung Kelurahan Dasan Geres Kecamatan Gerung, antara lain yakni kurangnya perhatian dan pengawasan dari orang tua, cara peneguran yang kurang tepat, pengaruh teman sebaya, Sikap masyarakat yang acuh tak acuh terhadap remaja yang bukan keluarganya, dan tidak adanya sanksi dan hukuman yang ditetapkan terhadap remaja yang melanggar (peraturan tertulis/awik-awik). Inilah problem atau kendala yang menghambat proses penanggulangan kenakalan remaja yang dilakukan di Lingkungan Aik Ampat Bawak Gunung.
Hubungan antara Ketahanan Pangan Rumah Tangga, dengan Kejadian Stunting pada Balita Usia 24-59 Bulan
Authors: Febriyanti Anggy , Isaura Emyr Reisha , Farapti Farapti
Published: November 2022

Latar Belakang; Stunting adalah kondisi gagal tumbuh pada anak balita (Bayi bawah lima tahun) akibat dari kekurangan gizi kronis sehingga anak terlalu pendek untuk usianya. Balita yang mengalami stunting akan memiliki tingkat kecerdasan yang tidak maksimal, menjadikan anak menjadi lebih rentan terhadap penyakit, dan pada saat dewasa dapat beresiko pada menurunnya tingkat produktivitas . Stunting tidak hanya dipengaruhi oleh satu faktor saja melainkan lebih dari satu faktor (multifaktor) diantaranya adalah kondisi ekonomi keluarga, pendidikan orang tua, pendapatan orangtua, ketahanan pangan rumah tangga, nutrisi ibu saat hamil, nutrisi 1000 HPK, asupan makanan dan penyakit infeksi.Tujuan: untuk mengetahui ada tidaknya hubungan antara ketahanan pangan rumah tangga dengan kejadian stunting pada balita usia 24-59 bulan di wilayah kerja Puskesmas Sumberaji, Kabupaten Lamongan.Metode: Penelitian cross sectional ini melibatkan 83 balita yang dipilih secara sengaja didasarkan pada pemilihan suatu karakteristik dengan teknik purposive sampling. Proses pengambilan data dilakukan melalui wawancara untuk variabel ketahanan pangan rumah tangga dan pengukuran antropometri untuk variabel stunting. Analisis data yang digunakan yaitu dengan uji statistik regresi logistik. Variabel bebas dari penelitian ini yaitu ketahanan pangan rumah tangga sedangkan variabel terikat dari penelitian ini yaitu stunting.Hasil: Hasil penelitian didapatkan 29 balita memiliki status gizi stunting (34,9%) dan 54 balita memiliki status gizi normal (65,1%). Selain itu, juga didapatkan jumlah rumah tangga tahan pangan 51,8%, rawan pangan tanpa kelaparan 28,9%, dan rawan pangan dengan kelaparan 18,1%. Berdasarkan uji regresi logistik rumah tangga rawan pangan tanpa kelaparan tidak berhubungan secara signifikan dengan kejadian stunting (p= 219). Sedangkan pada rumah tangga rawan pangan dengan kelaparan berhubungan positif signifikan dengan kejadian stunting (p<0,001), baik pada model yang tidak disesuaikan maupun pada model yang disesuaikan (β-Koefisien: 77,14 (95%CI: 8,72-682,53) ke (β-Koefisien: 87,70 (95%CI: 9,57-804,12) ke (β-Koefisien: 153,41 (95%CI: 11,46-2053,61).Kesimpulan: penelitian ini menyimpulkan bahwa terdapat hubungan antara ketahanan pangan rumah tangga dengan kejadian stunting. Oleh karena itu, perlu diberikan pendidikan gizi tentang pencegahan stunting, khususnya bagi masyarakat dengan kerawanan pangan rumah tangga. Kata Kunci: stunting, ketahanan pangan, balita
Pemberian Diet Tinggi Kalori Dan Rendah Protein Pada Pasien Covid-19 Dengan Gagal Ginjal Kronis Dan Penyakit Jantung: Sebuah Laporan Kasus
Authors: Pristyna Greena , Mahmudiono Trias , Sari Yuyun Eka
Published: November 2022

Latar Belakang: Coronavirus Disease 2019 (COVID-19) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) yangmana merupakan jenis coronavirus baru dan belum pernah diidentifikasi sebelumnya pada manusia. Adanya riwayat penyakit seperti tekanan darah tinggi, gangguan fungsi jantung, dan ginjal dapat meningkatkan risiko yang lebih besar untuk mengalami keparahan. Proses Asuhan Gizi Terstandar (PAGT) dilakukan dengan pemberian diet tinggi kalori dan rendah protein.Tujuan: untuk mengetahui tata laksana asuhan gizi terstandar pada pasien dengan pemberian diet tinggi kalori dan rendah protein pada pasien COVID-19 dengan riwayat penyakit gagal ginjal kronis dan jantung.Metode: Studi kasus dilakukan pada bulan Maret 2021 pada pasien RSI Jemursari Surabaya.Hasil: Setelah dilakukan monitoring dan evaluasi didapatkan hasil bahwa hasil laboratorium memiliki perubahan yang fluktuatif, terjadi perubahan jenis makanan dan cara pemberian yang diberikan sejalan dengan dilakukan hemodialysis pada pasien, fisik/klinis belum mulai membaik, serta asupan pasien meningkat dari hari ke hari namun terdapat beberapa pemenuhan zat gizi makro belum dapat mencapai target (<80%).Kesimpulan: pemulihan kondisi pasien tidak terbilang cukup baik, hasil pemantauan biokimia dan fisik/klinis secara masih menunjukkan perubahan yang fluktuatif, namun pada asupan makanan terjadi peningkatan meskipun target asupan beberapa zat gizi makro belum tercapai.
Efektivitas Media Sosial Instagram Milik Rumah Sakit di Kabupaten Serang Dalam Promosi Kesehatan COVID-19
Authors: Vionita Luthfia , Prayoga Diansanto
Published: November 2022

Latar Belakang: Dalam pemutusan rantai penyebaran COVID-19 maka dilakukan promosi kesehatan untuk memberikan informasi kepada masyarakat luas dalam meningkatkan kualitas kesehatan. Dalam promosi kesehatan ini diperlukan media untuk menyampaikan pesan. Salah satu media sosial tersebut ialah Instagram. Instagram merupakan salah satu media sosial yang banyak digunakan masyarakat khususnya kalangan muda. Banyak organisasi layanan kesehatan yang menggunakan media sosial salah satunya rumah sakit.Tujuan: Pada penelitian ini bertujuan untuk melihat efektivitas dari media sosial dalam mempromosikan kesehatan terkait COVID-19 pada rumah sakit di Kabupaten Serang.Metode: Penelitian ini merupakan penelitian kualitatif yang menggunakan data sekunder. Data berasal dari hasil pengamatan akun media sosial Instagram yang dimiliki oleh rumah sakit dengan berbagai tipe yang berada di Kabupaten Serang, total terdapat 3 akun media sosial Instagram. Data dikumpulkan berdasarkan postingan pertama yang terbit pada bulan Maret 2020 – 19 Oktober 2020. Data yang dikumpulkan untuk mengetahui engagement account yaitu dengan melihat total followers,  likess, dan comments.Hasil: Semua rumah sakit yang tersebar di Kabupaten Serang bertipe C. Rumah sakit di Kabupaten Serang memberikan pelayanan yang melibatkan teknologi dan informasi salah satunya penggunaan media sosial Instagram. Rumah Sakit Ibu dan Anak Permata Serdang tidak memilik postingan selama periode Maret 2020 – Oktober 2020, postingan pada akun Instagram rumah sakit Hermina Ciruas dan akun Instagram rumah sakit Kurnia Serang mempunyai topik dalam penyampaian pesan terkait COVID-19 sangat beragam. Engagement rate RS Hermina Ciruas yaitu sebesar 1,86%, engagement rate RS Kurnia Serdang sebesar 1,28%, dan engagement rate RSIA Permata sebesar 0%.Kesimpulan: Media sosial instagram bisa digunakan sebagai media promosi kesehatan terkait COVID-19 yang efektif bagi segmentasi usia muda.
Evaluasi Kegiatan Sub Bagian Data dan Informasi Pada Gugus Tugas COVID 19 di Kabupaten Tulungagung
Authors: Tyas Ratih Cahyaning
Published: November 2022

Background: Coronavirus Disease 19, commonly dubbed as COVID-19, has been widely spread across the globe since March 2020, and WHO has declared it a Pandemic. In Indonesia, the disease began to spread in June 2020. The spreading rate was so fast that it reached every part of the country, including the Tulungagung district in East Java. The Government of Tulungaggung has tried to curb the rapid spread of COVID-19 cases by establishing the “COVID-19 Handling Task Force Team”. The author was assigned in Data and Information in the task force, and of course, the performance is far from perfect. Therefore, an evaluation to measure the success rate of the programs conducted by the Sub Department of Data and Information of the COVID-19 Handling Task Force Team in Tulungagung District was made.Objectives: The purpose of this study was to evaluate the activities of the data and information sub-section on the Covid-19 task force in Tulungagung Regency.Methods: The works performed by volunteers in the COVID-19 Handling Task Force Team of Tulungagung District were observational participative, where the students are actively involved in controlling the cases. The students were given the task of the data and information. The primary responsibility of the data and information department is the evaluation of monitoring, information systems, and press release activities.Results: This final assignment/mini-thesis covers the implementation of activities at the Sub Department of Data and Information contains ten measured activities. The measurement was made by comparing the actual performance with the guideline in place.Conclusions: In conclusion, the analysis of activities at the Sub Department of Data and Information was made to 10 activity indicators. The result is that each indicator are consistent and aligned with the prevailing guidelines such as Ministry of Health Regulation number 45 of 2014 concerning Health Surveillance Implementation, COVID-19 Prevention and Control Guideline of 2020, and Behavior Change Communication (KPP) strategy in COVID-19 preventions.
Mengoptimalkan Asupan Zat Gizi sebagai Upaya Preventif dalam Mengatasi Masalah Kesehatan Mental
Authors: Kristy Alimin Nadila Cahyaningtyas
Published: November 2022

Latar Belakang: Zat gizi memiliki peranan penting untuk menjaga kesehatan mental seseorang. Hasil studi menjelaskan bahwa ketika seseorang dengan kondisi kesehatan mental yang tidak baik, akan sering mengalami kekurangan zat gizi tertentu, vitamin essensial, mineral, asam amino dan asam lemak omega-3. Dalam beberapa penelitian juga membuktikan bahwa semakin banyak seseorang mengonsumsi suatu makanan yang kaya akan buah-buah dan sayuran, tinggi lemak sehat, kacang-kacangan dan ikan serta rendah makanan olahan, maka semakin seseorang akan terlindungi dari gangguan mental.
Tujuan: Studi ini dilakukan untuk mengetahui upaya preventif dalam mengatasi masalah kesehatan mental dengan mengoptimalkan asupan zat gizi.
Metode: Literatur yang digunakan dari referensi article, e-book dan research selama 10 tahun terakhir, yaitu 2013-2021, dengan menggunakan kata kunci asupan zat gizi, kesehatan mental, peranan dan upaya preventif.
Ulasan: : Berdasarkan literatur yang digunakan dari referensi article, e-book dan research selama 10 tahun terakhir, yaitu 2013-2021, didapatkan hasil bahwa adanya pengaruh pengaturan pola konsumsi makanan yang sehat dengan menambah asupan-asupan zat gizi, seperti asam lemak omega-3, asam folat, asam amino (protein), vitamin B12, vitamin A, C, D dan E, Selenium, Zinc, dan Probiotik terhadap kesehatan mental seseorang.
Kesimpulan: Kofaktor zat gizi dalam mikronutrien dapat memainkan peran penting dalam mengarahkan proses metilasi DNA dan regulasi epigenetik telah banyak terlibat dalam perkembangan otak dan kesehatan mental. Dengan demikian, pengoptimalan asupan zat gizi, seperti asam lemak omega-3, asam folat, asam amino (protein), vitamin B12, vitamin A, C, D dan E, Selenium, Zinc, dan Probiotik, dapat menjadi salah satu alternatif yang dapat dilakukan oleh masyarakat sebagai upaya preventif dalam mengatasi masalah kesehatan mental.
Hubungan Antara Perilaku Makan dan Healthy Eating Index dengan Status Gizi Anak Usia Sekolah di SDI Darush Sholihin Kabupaten Nganjuk
Authors: Latersia Yovicristy , Alfinnia Silvia Alfinnia , Muniroh Lailatul
Published: November 2022

Latar Belakang: Anak usia sekolah berada pada tahapan tumbuh kembang sehingga asupan bergizi sangat diperlukan untuk mendukung pertumbuhan dan perkembangan anak. Apabila terjadi ketidakseimbangan antara asupan dan pemenuhan gizi, masalah gizi akan muncul.
Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara perilaku makan dan Healthy Eating Index dengan status gizi anak usia sekolah di SDI Darush Sholihin, Kabupaten Nganjuk.
Metode: Penelitian ini merupakan studi observasional analitik dengan desain penelitian cross-sectional. Besar sampel 48 siswa yang dipilih menggunakan proportional random sampling. Data yang dikumpulkan mencakup berat badan, tinggi badan, Food Frequency Questionnaire, serta food recall 2x24 jam. Analisis data dilakukan dengan uji korelasi Spearman dengan nilai signifikansi 0,05.
Hasil: Sebagian besar siswa adalah laki-laki (54,2%), rerata asupan energi 1126,08±287,99 kkal/hari, tingkat asupan rendah seperti karbohidrat (98%), protein (47,9%), dan lemak (64,6%), jarang makan makanan pokok (60,4%), lebih sering makan lauk nabati (43,8%), tidak pernah makan sayur (58,3%), tidak pernah makan buah (81,2%), serta tidak pernah mengonsumsi jajanan (75%). Tidak ada hubungan antara perilaku makan makanan pokok (p=0,101), lauk hewani (p=0,212), lauk nabati (p=0,829), sayuran (p=0,751) dan jajanan (p=0,109), dan skor Healthy Eating Index (p=0,194) dengan status gizi. Namun, perilaku makan buah (p=0,040) berhubungan dengan status gizi.
Kesimpulan: Tidak terdapat hubungan positif antara perilaku makan makanan pokok, lauk hewani, lauk nabati, sayuran, dan jajanan, serta skor HEI dengan status gizi. Namun, ada hubungan antara perilaku makan buah dengan status gizi. Anak yang sering mengonsumsi buah tanpa memperhatikan kandungan gula dan cara penyajian berisiko mengalami obesitas. Pendidikan gizi kepada pihak sekolah maupun orang tua terkait perilaku makan sehat terutama buah sangat dibutuhkan untuk mencegah obesitas dan mencapai tumbuh kembang yang optimal.
Literature Review: Potensi Umbi Garut sebagai Pangan Alternatif untuk Penderita Diabetes Melitus
Authors: Nur Mahwita Adi Setyaningrum Wita , NUR MAHWITA ADI SETYANINGRUM WITA
Published: November 2022

Latar Belakang: International Diabetes Federation (IDF) (2021) menyebutkan pada tahun 2021 diperkirakan bahwa 537 juta orang menderita diabetes, angka tersebut diproyeksikan akan mengalami peningkatan mencapai 643 juta orang pada tahun 2030 dan 783 juta orang pada tahun 2045. Salah satu pengaturan pola makan untuk membantu mengendalikan kenaikan glukosa darah adalah dengan memilih sumber pangan yang memiliki indeks glikemik (IG) yang rendah. Umbi garut memiliki kandungan indeks glikemik yang rendah serta senyawa bioaktif seperti polisakarida larut air, serat pangan, dan diosgenin yang berpotensi dalam penurunan kadar gula darah
Tujuan: Tujuan penulisan literature review ini adalah untuk memberikan informasi dan gambaran tentang kandungan gizi dan senyawa bioaktif pada umbi garut yang memiliki pengaruh positif terhadap penurunan gula darah, serta pemanfaatannya yang diolah menjadi berbagai jenis masakan.
Metode: Metode yang digunakan pada penelitian ini adalah study literature dengan menggunakan desain Systematic Literature Review Artikel dicari dengan menggunanakan database Google Scholar. Setelah dilakukan screening, 11 artikel memenuhi syarat dan kriteria.
Ulasan: Berdasarkan beberapa hasil penelitian diketahui umbi garut segar dan olahannya memiliki indeks glikemik di bawah 55 yang tergolong rendah. Tepung garut mengandung 1,12% serat pangan larut air, 1,49% serat pangan tidak larut air 3,98% polisakarida larut air, serta 2,16 mg/100 g diosgenin.
Kesimpulan: Kesimpulan yang didapatkan dari penelitian ini yaitu umbi garut memiliki potensi sebagai makanan pokok alternatif untuk penderita diabetes melitus karena kandungan indeks glikemiknya yang rendah dan mudah diolah menjadi berbagai jenis makanan.
Perbedaan Polutan Penyebab Polusi Udara Dalam Ruangan Pada Negara Maju dan Berkembang: Literature Review
Authors: Tarra Zettira  , Ririh Yudhastuti
Published: November 2022

Latar Belakang: Sebagian besar orang menghabiskan lebi banyak waktu di dalam ruangan, seperti di rumah. Adanya polusi udara dalam ruangan memiliki dampak kesehatan pada penghuni rumah seperti munculnya gejala gangguan saluran pernapasan.

Tujuan: Penelitian ini bertujuan untuk menganalisis perbedaan polusi udara dalam ruangan di negara maju dan berkembang serta dampaknya pada saluran pernapasan.

Metode: Metode yang digunakan untuk mengumpulkan artikel yaitu dengan literature review. Artikel diambil dari database Pubmed, Sage Journal, Science Direct, dan Scopus.

Ulasan: Kontaminan udara yang ditemukan di negara maju antara lain kelembaban, jamur, asap rokok, dan bahan kimia seperti formaldehyde. Pada negara berkembang, kontaminan udara dalam ruangan yang sering ditemukan yaitu asap hasil pembakaran ketika memasak.

Kesimpulan: Hasil telaah artikel menunjukkan kontaminan serta sumber kontaminan udara dalam ruangan pada negara maju dan berkembang berbeda karena perbedaan kondisi rumah dan aktivitas penghuni.
Literature Review: Hubungan Pajanan Benzena, Usia, dan Masa Kerja dengan Kadar Trans, Trans – Muconic Acid (ttMA) Urin pada Pekerja Terpapar Benzena
Authors: Christiansi Welldelin Yufuria
Published: November 2022

Latar Belakang: Benzena adalah salah satu zat atau bahan kimia yang sering ditemukan dan digunakan di dalam bidang perindustrian, baik di dalam industri percetakan, pengeleman, obat-obatan, plastik, karet buatan, pewarna hingga bensin. Hal ini menyebabkan paparan benzena yang diterima manusia atau pekerja yang bekerja dekat dengan sumber benzena rentan menerima risiko atau gangguan kesehatan yang disebabkan oleh benzena. Salah satu metabolit yang dapat diukur sebagai tanda dari adanya paparan benzena di dalam tubuh adalah ttMA dalam urin.Tujuan: Studi literatur ini bertujuan untuk menganalisis hubungan antara pajanan benzena dengan kadar ttMA urin pada pekerja berdasarkan penelitian yang sudah dilakukan sebelumnya.Metode: Metode penelitian ini adalah literature review yang dimana digunakan untuk mengkaji, memahami, dan menafsirkan penelitian-penelitian yang ada yang sesuai dengan topik yang diambil dengan bersumber dari artikel yang diterbitkan dalam kurun waktu 5 tahun.Hasil: Hasil dari literature review menunjukkan bahwa hampir seluruh penelitian (75%) yang dirangkum menyatakan adanya hubungan antara pajanan benzena dengan kadar ttMA urin. Sedangkan variabel seperti usia dan masa kerja mayoritas (>50%) tidak berhubungan dengan kadar ttMA urin.Kesimpulan: Kesimpulan dalam penelitian ini yang dapat diambil adalah pajanan benzena berhubungan dengan kadar ttMA urin seseorang atau pekerja yang bekerja dekat atau sering terpapar dengan benzena di lingkungan kerjanya. Sedangkan variabel lain seperti usia dan masa kerja tidak memiliki hubungan yang signifikan.Kata kunci: pajanan benzena, usia, masa kerja, kadar ttMA urin
GACOR (Gastric Acid Detector): Inovasi Alat Pengukur Tingkat Asam Lambung
Authors: Sahroni, Ph.D. Alvin , Maulana Putra Taufan , Murad Dwiki Akmal
Published: November 2022

GERD merupakan suatu keadaan patologis di mana cairan asam lambung mengalami refluks sehingga masuk ke dalam esofagus dan menyebabkan gejala. Berbagai gejala akibat keterlibatan esofagus, faring, laring dan saluran napas. Sehingga gejala yang dialami oleh penderita akan mengalami sensasi rasa terbakar di dada, sulit menelan, mual, bau mulut, mengeluh mulas dan regurgitasi. Biasanya penderita GERD didiagnosa hanya melalui anamnesis, sedangkan pH asam lambung tidak dilakukan pengukuran. Ada pun biasanya menggunakan pemeriksaan endoskopi untuk mengukur pH asam lambung. Untuk mengatasi permasalahan tersebut, kebutuhan untuk menyelesaikan masalah adalah membuat alat yang dapat mengukur pH asam lambung tidak semahal pemeriksaan endoskopi, pemeriksaan yang non invasif, dan tidak harus dengan bantuan tenaga medis. Mengusung penggunaan yang mudah, menggunakan sensor pH untuk mendeteksi cairan saliva. Maka kami mengusulkan GACOR (Gastric Acid Detector): Inovasi Alat Pengukur Tingkat Asam Lambung Berbasis Sensor pH. Menggunakan sensor pH ini nantinya untuk mengukur cairan saliva, sensor pH akan mendeteksi nilai keasaman melalui mekanisme pertukaran ion elektronik dan lautan terukur.
IMPLEMENTASI PEMBELAJARAN BAHASA ANAK USIA DINI DI MASA PANDEMI COVID 19
Authors: Dhieni Nurbiana , Suharti Suharti , Hapidin
Published: November 2022

Bahasa merupakan sarana untuk berkomunikasi. Melalui berbahasa seseorang atau anak akan dapat mengembangkan kemampuan sosialnya dengan orang lain. Bahasa merupakan salah satu aspek perkembangan pada anak usia dini yang penting untuk dikembangkan. Pengembangan  bahasa pada anak usia dini dapat dilakukan dengan desain pembelajaraan yang dilakukan oleh guru pada lembaga PAUD. Tujuan pelaksanaan kegiatan pengabdian masyarakat ini adalah implementasi pembelajaran bahasa anak usia dini di Pulau Untung Jawa Kepulauan Seribu. Objek pengabdian masyarakat ini adalah guru pendidikan anak usia dini. Pelaksanaan kegiatan pengabdian masyarakat ini menggunakan metode pendampingan bagi guru secara daring selama pandemic covid—19. Pendampingan ini dilakukan melalui seminar dan workshop yang dilaksanakan secara online untuk memberikan pemahaman kepada guru tentang pembelajaran bahasa anak usia dini yang melaksanakan belajar jarak jauh atau belajar dari rumah sebagai imbas ditutupnya lembaga PAUD di masa pandemic covid-19. Hasil kegiatan in berupa terbentuknya pemahaman guru untuk implementasi pembelajaran bahasa pada anak usia dini meskipun anak-anak belajar dari rumah. Sehingga diharapkan guru PAUD dapat lebih kreatif merancang pembelajaran bahasa yang menarik di berbagai kondisi.
Accurate Diagnostic Tissue Segmentation and Concurrent Disease Subtyping with Small Datasets
Authors: Frank Steven
Published: November 2022

· Purpose: to provide a flexible, end-to-end platform for visually distinguishing diseased from undiseased tissue in a medical image, in particular pathology slides, and classifying diseased regions by subtype. Highly accurate results are obtained using small training datasets and reduced-scale source images that can be easily shared.
· Approach: an ensemble of lightweight convolutional neural networks (CNNs) is trained on different subsets of images derived from a relatively small number of annotated whole-slide histopathology images (WSIs). The WSIs are first reduced in scale to preserve anatomic features critical to analysis but also facilitate convenient handling and storage. The segmentation and subtyping tasks are performed sequentially on the reduced-scale images using the same basic workflow – generating and sifting tiles from the image, then classifying each tile with an ensemble of appropriately trained CNNs. For segmentation, the CNN predictions are combined using a function to favor a selected similarity metric, and a mask or map for a a candidate image is produced from tiles whose combined predictions exceed a decision boundary. For subtyping, the resulting mask is applied to the candidate image, and new tiles are derived from the unoccluded regions. These are classified by the subtyping CNNs to produce an overall subtype prediction.
· Results and conclusion: this approach was applied successfully to two very different datasets of large WSIs, one (PAIP2020) involving multiple subtypes of colorectal cancer and the other (CAMELYON16) single-type breast cancer metastases. Scored using standard similarity metrics, the segmentations outperformed more complex models typifying the state of the art.
Carbonate system in the Cabo Frio upwelling
Authors: Silva Carlos Augusto Ramos e , Fernandes Livia Viana de Godoy , de Souza Flavo Elano Soares , Marotta Humberto , Fernandes Flavio da Costa , Mello Thaise Machado Senez , Monteiro Nicole Silva Caliman , Rocha Anderson Araújo , Coutinho Ricardo , Fernandes Lohengrin Dias de Almeida , Damasceno Raimundo Nonato , Santos Ludmila Caetano dos
Published: November 2022

The quantitative assessment of the carbonate system represents one of the biggest challenges toward the "Sustainable Development Goals" defined by the United Nations in 2015. In this sense, the present study investigated the Spatio-temporal dynamics of the carbonate system and the effects of the phenoms ENOS and ENSO over the Cabo Frio upwelling area. The physical characterization of the site was carried out through data on wind speed and sea surface temperature (SST). Water samples were also collected during the oceanographic cruise onboard the Diadorim R/V (Research Vessel). From these samples, the parameters of absolute and practical salinity, density, pH, total alkalinity, carbonate, calcite, aragonite, \(C{O}_{3}^{2-}\), \(HC{O}_{3}^{-}\), dissolved inorganic carbon, carbon dioxide, partial pressure of carbon, calcium, and total boron were obtained. After the physical-chemical survey, the same parameters were calculated through thermodynamic modeling with the Marine Chemical Analysis (AQM) software loaded with the results of the following parameters: temperature, salinity, TA, and pH parameters. This manuscript presents an original data on the carbonate system and the "acidification" process influenced by the Cabo Frio upwelling, which directly depends on the El Niño and La Niña phenomena oscillations in the sea surface temperature (SST).
Drastic Fluorescence Enhancement of Metal-Organic Framework for Ultra-Efficient Detection of Trace Benzene Vapor
Authors: Li Wen-Bin , Wu Ying , Zhong Xiao-Feng , Chen Xiong-Hai , Liang Gang , Ye Jia-Wen , Mo Zong-Wen , Chen Xiao-Ming
Published: November 2022

Indoor detection of volatile organic compound (VOC, such as benzene and toluene vapors) concentration is necessary due to the serious toxicity hazards even at trace level. However, physisorbents usually exhibit weak interactions between sorbate and sorbent, thus exhibiting poor responsive signal especially in the presence of trace concentrations of VOCs. Herein, we report a new flexible metal-organic framework [Sr2(BINDI)(DMF)(H2O)]∙G (H4BINDI = N,N′-bis(5-isophthalic acid)naphthalenediimide, DMF = N,N-dimethylformamide, G = 0.6DMF) that exhibits interesting pore-opening behavior after immersing in H2O, hence allowing aromatic hydrocarbon molecules to diffuse into the pores. Interestingly, the pore-opening phase [Sr2(BINDI)(H2O)2] shows significant (∼116 fold) and extremely fast (< 1 minute) fluorescence "turn-on" behavior after exposed to saturated benzene vapor. The limit of detection concentration for benzene vapor can be calculated as 77 ppb. Thus this material represents the first MOF as fluorescent sensor achieving visual detection of trace benzene vapor by naked eyes. Theoretical calculations and single-crystal structure of [Sr2(BINDI)(H2O)2]⊃benzene reveal that the special "bilateral π-π stacking" interactions between electron-rich aromatic hydrocarbon and electron-deficient NDI cores facilitate electron transfer, and greatly enhance the intensity of fluorescence. Furthermore, this material can be fabricated into simple test strips, which enable visual detection of trace benzene vapor (3 ppm) under UV light.
Your neighborhood matters: an ecological social determinant study of the relationship between residential racial segregation and the risk of firearm fatalities
Authors: Shour Abdul R. , Anguzu Ronald , Muehlbauer Alice , Joseph Adedayo , Oladebo Tinuola , Puthoff David , Onitilo Adedayo A
Published: November 2022

Background: Firearm fatalities are a major public health concern, claiming the lives of 40,000 Americans each year. While firearm fatalities affect all, it is unclear how social determinants such as residential segregation affect firearm fatalities. To address this knowledge gap, this study investigates the relationship between residential segregation and the likelihood of firearm fatalities.
Methods: Ecological county-level data for 72 Wisconsin counties from the American Community Survey (ACS) were merged with Vital Statistics System mortality records (2015-2019). The study outcome was firearm fatalities, defined as the number of deaths due to firearms per 100,000 population from 2015 to 2019 (used as a continuous variable). The independent variable was residential segregation, using the 2015-2019 ACS-Dissimilarity Index (DI), which measures the degree to which non-white and white residents are distributed across counties and ranges from 0 (complete integration) to 100 (complete segregation), with higher values indicating greater residential segregation. Confounders included income inequality (2015-2019) and community resilience (2019). Poisson regression analyses were conducted using STATA/MP-v.17.0. P-values of ≤0.05 were considered statistically significant.
Results: From 2015 to 2019, there were 843 firearm fatalities. Mean (SD) residential segregation was 32.4 (13.1). Bivariate analysis indicates that an increase in residential segregation was significantly associated with increased firearm fatalities (Coef.:0.1,95%CI:0.05-0.06). Adjusted model results indicate that for every increase in residential segregation (by DI), the likelihood of firearm fatalities increased by 0.01% (Coef.:0.01,95%CI:0.007-0.02).
Conclusion: Residential segregation, among other social determinants, increases the likelihood of firearm fatalities. This research helps healthcare systems-based practitioners understand how the larger social context influences gun violence disparities.
Modelling of the effect of ATH fillers on the rheology, curing kinetics, and flexural properties of the epoxy resin forming the hydraulic turbines' stay vanes extension
Authors: Ouadday Rim , Boukhili Rachid , Vadean Aurelian , Abusrea Mahmoud
Published: November 2022

Epoxy resins are essential for the manufacturing of GFRP/XPS foam sandwich structures used for hydraulic turbine extension stay vanes. Their properties during and after curing are key factors for the performance of the entire hybrid composite structure. This paper introduces experimental characterization and modeling of the influence of the quantity and size of ATH fillers on the curing and post-curing characteristics of the epoxy resin. The experimental investigation involves the maximum temperature, polymerization time, shrinkage, viscosity, and flexural properties. The mass fractions of the ATH were 10, 20, 30, 40, 50, and 60%, and the particle sizes were 2, 4, 6, 8, and 12 µm. In addition, we utilized the multivariate polynomial regression (MPR) and artificial neural network (ANN) methods to develop empirical models to predict the maximum temperature, polymerization time, shrinkage, and flexural modulus. The experimental results showed that increasing ATH mass fraction with smaller particle size delayed polymerization and lowered the maximum temperature. The experimental viscosity values showed that Mooney model can accurately calculate viscosity as a function of ATH mass fraction and particle size, compared to the Quemada and Krieger-Dougherty models. Adding ATH increased flexural strength, modulus, and breakage strain. The developed models achieved a higher than 0.9 correlation coefficient between the predicted and measured responses and can be used to enhance the design and control the casting of the proposed sandwich structures.
Cultural adaptation and validation of Sinhala version of Modified Caregiver Strain Index
Authors: Ramadasa Udayangani , Silva Shehan , Uditha Udumulla , Perera Suraj , Lekamwasam Sarath
Published: November 2022

Background
Care givers of Palliated patients are at risk of adverse physical, psychosocial and emotional sequelae in varied nature. Efficient and valid assessment tools facilitate early detection to take corrective measures. The Modified Caregiver Strain Index (MCSI), composed of domains associated with caregiver strain is a simple and brief tool that can be used in both clinical and field settings. This study aims to adapt and validate this in order to cater effective palliative care services in Sri Lanka.
Methods
After cross-cultural adaptation, 200 primary caregivers in 3 teaching hospitals were recruited. The internal consistency, item-total correlations, of the 13-item S-MCSI were performed. The criterion validity was assessed by Pearson correlation between the total scores of S-MCSI, the Karnofky Performance Scale and the Barthel index. Construct validity was determined by the principal component analysis keeping the Varimax with Keiser normalization as the rotation method. The Kaiser-Meyer-Olkin test (KMO) and Bartlett’s test of sphericity statistics were also performed to determine the adequacy of the sample and correlations between items, respectively. The number of factors was determined by the Scree plot, percentage of variance explained by each component and number of Eigen values over 01 (Kaiser-Guttman rule).
Results
The total MCSI score ranged 0 to 26. The overall Cronbach’s alpha of the 13-item questionnaire was 0.80 while item-total corrections ranged 0.34 to 0.62, exception of one item (0.11). Inverse correlations were demonstrated in total scores of MCSI and Karnofky Performance Scale (r =- 0.32, p < 0.001) and Barthel index (r =-0.34, P < 0.001). A Kaiser-Meyer-Olkin value of 0.79 (p < 0.001) for Bartlett’s test indicated adequate sampling and nonlinearity of factors. The Scree plot showed a three-factor structure explaining 57% of the variation. Items regarding personal wellbeing of caregiver loaded together while the effects on the family loaded separately. Adjustment of personal concerns and family issues along with time alteration grouped as the third factor.
Conclusions
The study showed that the Sinhala version of MCSI has adequate psychometric properties and reliability to be used as a validated tool to estimate the caregiver burden within a short time period for any health care workers.
Cell Tracking with Multifeature Fusion]{Cell Tracking with Multifeature Fusion
Authors: Wang Fei , Li Huawei , Yang Wanli , Jin Shidong , Gao Peng
Published: November 2022

Cell tracking is currently a powerful tool in a variety of biomedical research topics. Most cell tracking algorithms follow the tracking by detection paradigm. Detection is critical for subsequent tracking. Unfortunately, very accurate detection is not easy due to many factors like densely populated, low contrast, and possible impurities included. Keeping tracking multiple cells across frames suffers many difficulties, as cells may have similar appearance, they may change their shapes, and nearby cells may interact each other. In this paper, we propose a unified tracking-by-detection framework, where a powerful detector AttentionUnet++, a multimodal extension of the ECO algorithm, and an effective data association algorithm are included. Experiments show that the proposed algorithm can outperform many existing cell tracking algorithms.
A data–driven model to predict a household’s capacity to graduate. Case ofUSAID/Twiyubake Program
Authors: Muramira Absolom , Nkurunziza Joseph
Published: November 2022

The USAID funded Twiyubake program applied a dual systems and family-centered approach to provide a comprehensive package of services that aimed to strengthen the capacity and resilience of the targeted vulnerable families/households. The program built upon and strengthened existing community care structures to deliver and sustain high quality services to the enrolled households including economic strengthening, health promotion, water sanitation and hygiene etc. The Household Vulnerability and Graduation Assessment was used by Twiyubake program to determine household capacity to graduate from direct program assistance. The dataset used in this study came from the Twiyubake program’s annual monitoring data. Five different machine learning classification models namely Logistic Regression, Random Forest, Gaussian Naive Bayes, K-Nearest Neighbors, and Multi-Layer Perceptron, were used to build a predictive model of household capacity to graduate. The performance of predictive models was assessed using a variety of metrics, including the confusion matrix, accuracy, precision, recall, F1 score, and the Area under the Receiver Operating Characteristics. The results showed that the Random Forest model correctly predicted household graduation capacity with 94.8 percent of the accuracy, with recall score of 94.8 percent, precision score of 94.8 percent, and F1 score of 94.8 percent. Overall, all the machine learning algorithms performed very well with over 85 percent performance on the different evaluation parameters used. The Random Forest model was recommended as the best household graduation prediction classifier for the Twiyubake program since it performed better than the rest.
PAK Inhibitor FRAX486 Represses Metastatic Potential of Triple-negative Breast Cancer Cells by Blocking Autophagy
Authors: Li Huihui , Lyu Liang , Li Haiyan , Lu kefeng , Jiang Shu
Published: November 2022

Triple-negative breast cancer (TNBC) is a unique breast cancer subtype with high risk for metastasis and recurrence and poor prognosis. Epithelial-mesenchymal transition (EMT) endows epithelial cells with mobility to move to distant sites, which is essential for metastasis of TNBC to organs including lung. Autophagy, an intracellular degradation process through forming double-layered lipid autophagosome that transports cytosolic cargoes into lysosome after autophagosome-lysosome fusion, is involved in EMT of cancer cells. Here, we report a role for FRAX486, a potent P21- activated kinase 2 (PAK2) inhibitor, in TNBC suppression both in vitro and in vivo by blocking autophagy. Mechanistically, FRAX486 inhibits autophagy in TNBC cells through targeting PAK2, leading to the ubiquitination and proteasomal degradation of STX17 that mediates autophagosome-lysosome fusion. The inhibition of autophagy by FRAX486 causes up-regulation of epithelial marker protein E-cadherin and thus suppresses the migration and metastasis of TNBC cells. The effects of FRAX486 in TNBC metastasis suppression are verified to be relied on PAK2 and autophagy inhibition. Together, our results provide a molecular basis for the application of FRAX486 as a potential option to inhibit the metastasis of TNBC.
Prevalence and antibiotic susceptibility pattern of bacteria from sepsis suspected neonates at St. Paul Hospital Millennium Medical college, Addis Ababa, Ethiopia.
Authors: Sherif Merema , Abera Dessie , Desta Kassu
Published: November 2022

Background: Neonatal sepsis is the major cause of neonatal mortality and morbidity, especially in low and middle-income countries. Continuous monitoring of pathogens and their antibiotic susceptibility pattern is crucial for managing neonatal sepsis. This study aimed to determine neonatal sepsis due to bacteria, antibiotic resistance patterns, and patient outcomes at St. Paul’s Hospital Millennium Medical College.
Method: Across sectional study was conducted on 400 neonates at St. Paul’s Hospital Millennium Medical College from March 2020 to July 2020. Socio-demographic characteristics were collected from each patient using questionnaires. About 2ml of blood was drawn aseptically and inoculated at the bedside on Tryptone Soya Broth. Bacterial identification was performed by using standard microbiological techniques. The disk diffusion method was used to determine the antibiotic susceptibility patterns of each isolated bacteria. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 20 software.
Results: The overall prevalence of neonatal septicemia was 21% (84/400). Of this, 79.8% (67) and 20.3% (67) were gram-negative and gram-positive bacteria respectively. Klebsiella spp, 44% (37), E. coli 21.6% (19), and Coagulase negative Staphylococci 15.47% (13) were the leading cause of neonatal sepsis. Ciprofloxacin and Amikacin were the most effective antibiotics for gram-negative bacteria while Vancomycin, Clindamycin, and Ciprofloxacin were effective against gram-positive bacteria. Low birth weight and preterm were associated with neonatal septicemia (AOR= 49.90, 95%CI=15.14-123.081, P=0.002, and AOR=18.20, 95% CI=6.835-27.541, P=0.004) respectively.
Conclusion: Klebsiella spp and E. coliwere frequently isolated bacteria in neonatal sepsis. The overall prevalence of MDR was significantly high, and commonly used antibiotics such as Ampicillin and Gentamicin were infective to treat neonatal sepsis. This indicates the necessity of early detection of septicemia and continuous evaluation of antibiotic resistance. A large-scale study is required to investigate the magnitude of neonatal sepsis.
The Clinical Learning Expieriences of Male Nursing Students in Maternity Wards at Training Hospitals in Khomas Region, Namibia.
Authors: Joao Ildefonsina Natalie , Kadhila Joseph Galukeni
Published: November 2022

Background
Clinical learning in nursing is very important because this when students get to practice what they learn theoretically and actually put in to action. Many males are now starting to join the nursing field, and with this they tend to have a more different experience than that a female nursing student would experience, especially in the maternity wards. The purpose of this study was to explore and describe the clinical learning experiences of second, third and fourth year male degree nursing students regarding their clinical learning experiences in the maternity wards at training hospitals in Khomas region.
Methods
The researcher collected data by conducting one-one interviews with male nursing students from the fourth, third and second year. The data was analyzed according to the two objectives of this study based on Teschs method of qualitative data analysis.
Results
The study revealed that the male nursing students endured many challenges such as rejection from patients due to their cultural beliefs, with that it had an impact on their self- esteem and self-worthiness as student nurses. The participants also mentioned that they experienced a poor interpersonal relationship with the registered nurses and that the clinical instructors were not very present with them during their clinical practice.
Conclusion
With the above mentioned, the researcher recommends that the training institutes put more effort in preparing male students about the challenges they might face when they do enter the clinical setting, this will help male students be better prepared and deal better with the challenges they might face. The training hospitals and the training institutions can set up a program where male nursing students are placed or delegated at least once with another male registered nurse so that the male nursing student may have a role model and not feel like his alone. All of this is critical for the professional growth of the male nursing students.
Artesunate acts through cytochrome c to inhibit growth of pediatric AML cells
Authors: Hill Kristen S. , Schuler Erin E. , Ellingson Sally R. , Kolesar Jill M.
Published: November 2022

Artesunate is a derivative of artemisinin, an active compound isolated from Artemisia annua which has been used in Traditional Chinese Medicine and to treat malaria worldwide. Artemisinin derivatives have exhibited anti-cancer activity against both solid tumors and leukemia. The direct target(s) of artesunate are controversial; although, heme-bound proteins in the mitochondria have been implicated. We utilized computational modeling to calculate the predicted binding score of artesunate with heme-bound mitochondrial proteins and identified cytochrome c as potential artesunate target. UV-visible spectroscopy showed changes in the absorbance spectrum, and thus protein structure, when cytochrome c was incubated with artesunate. Artesunate induces apoptosis, disrupts mitochondrial membrane potential, and is antagonized by methazolamide in pediatric AML cells indicating a probable mechanism of action involving cytochrome c. We utilized a multi-disciplinary approach to show that artesunate can interact with and is dependent on cytochrome c release to induce cell death in pediatric AML cell lines.