bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic marketing capability and strategic human resource management: predictors of performance in Santa Catarina's hotel industry
Authors: De Castro Junior Deosir Flávio Lobo , De Abreu Jean Carlos , Miura Marcio Nakayama , Silveira-Martins Elvis
Published: April 2023

This investigation aims to analyze the relationship between Dynamic Marketing Capabilities and Strategic Human Resource Management as predictors of Performance in Santa Catarina Executive Hotels. To achieve this objective, already validated scales were used. To analyze the Dynamic Marketing Capability, the scale developed by Desarbo et al. (2005) was used. For Strategic Human Resource Management, the scale developed by Barreto (2011) was chosen, and for the dependent variable, the scale developed by Carvalho (2012). The data collection was carried out through the survey technique, along with 259 managers of the Executive Hospitality of Santa Catarina. For data analysis, the softwares EXCEL, SPSS-IBM, and AMOS-IBM were used to gather data. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) tests, and structural equation modeling (SEM) were used to achieve the research objective. The obtained results confirm the positive and significant relationship between Dynamic Marketing Capability and Strategic Human Resource Management as predictors of superior performance in Santa Catarina's executive hospitality.
Safety risk assessment of port facilities
Authors: Da Rosa Izaias Otacilio , De Abreu Jean Carlos , De Castro Junior Deosir Flávio Lobo , Silveira-Martins Elvis , Miura Marcio Nakayama
Published: April 2023

The protection of critical infrastructures has become a concern for the achievement of the strategic purposes of countries and organizations. Brazilian government began to demand from port facilities the compulsory structuring of protective measures to meet demands agreed with international entities, such as the development of security risk analysis plans. This study provides a constructivist approach to the analysis of security risks in port facilities, enhancing the understanding of its managers from a multi-criteria perspective. Thus, the assumptions of the MCDA-C methodology were employed in a study case conducted at the Santa Catarina Port Terminal. However, as a result, it was possible to include in the same model technical aspects associated with the structuring of planning and risk analysis and subjective aspects of how a manager attributes greater relevance to elements that influence his performance regarding the safety of the port facility.
A model proposal for the technical assistance and rural extension service execution in Brazil
Authors: Cerveira Ricardo , Do Prado Nágela Bianca , Da Cunha Christiano França
Published: April 2023

ABSTRACTThis study presents a proposal for a model for execution of Technical Assistance and Rural Extension (TARE) services in Brazil, presenting a flow of actions through methodological tools. For this purpose, the study used a mixed methodological approach, that is, it used the principles of data triangulation, which comprised a survey of qualitative primary data and secondary quantitative data to prove the evidence. In other words, this study raised, from semi-structured interviews with specialists in the execution of TARE, the main methodological tools used in the execution of that service. Based on the terms most frequently cited by the interviewees, a search syntax developed to carry out a systematic review of the literature to theoretically prove the tools raised. As a result of the verification, it was possible to identify a model based on six main TARE execution tools: awareness, diagnosis, individual service, collective service, reference unit and program. This article has as its main contribution the offer of a model validated in the literature. Proposes to standardize a model for the design of TARE notices, and execution plans to contribute with the maximum efficiency in offering the service to the beneficiaries.
ĐÁNH GIÁ TƯƠNG ĐỒNG GIỮA CÁC THIẾT BỊ REALTIMR PCR SỬ DỤNG TRONG KIỂM ĐỊNH CHẤT LƯỢNG SINH PHẨM CHẨN ĐOÁN
Authors: Đinh Thị Phương Thảo  , Phạm Thị Hồng Thúy  , Vũ Thị Thu Hường  , Nguyễn Thị Tường An  , Vũ Thị Phượng
Published: April 2023

Realtime PCR là kỹ thuật phổ biến trong các bộ sinh phẩm chẩn đoán sinh học phân tử sử dụng trên một hoặc nhiều hệ thống thiết bị Realtime PCR khác nhau. Hiện nay cũng có nhiều loại hệ thống realtime PCR, mỗi loại lại khác nhau về hệ thống khuếch đại, nguồn kích thích và phát hiện huỳnh quang, có thể dẫn đến các sai lệch kết quả khi đánh giá chất lượng sinh phẩm. Chúng tôi sử dụng phương pháp nghiên cứu mô tả thực nghiệm in vitro cho đánh giá sự tương đồng thiết bị của 04 hệ thống Realtime PCR đang sử dụng tại Viện Kiểm định Quốc gia Vắc xin và Sinh phẩm Y tế (NICVB) bao gồm ABI7500; Realtime PCR CFX96 Touch Bio- Rad; abCyclerQ (AIT biotech) và QuantStudioTM5. Nghiên cứu được thực hiện với mục tiêu so sánh kết quả giới hạn phát hiện (LOD) trên 04 hệ thống Realtime PCR khác nhau trên cùng mẫu chuẩn và hóa chất sinh phẩm. Phương pháp và tính toán kết quả theo quy trình chuẩn của khoa Sinh phẩm Y tế, NICVB. Kết quả  LOD của 04 hệ thống thiết bị lần lượt là 5,2 RNA copies / phản ứng (95%CI: 3,3-8,0 RNA copies/phản ứng), 10,77 RNA copies/phản ứng (95%CI: 7,62-15,24 RNA copies/phản ứng), 14,86 RNA copies/phản ứng (95%CI: 10,71-20,64 RNA copies/phản ứng), 10,04 RNA copies/phản ứng (95%CI: 7,06-14,30 RNA copies/phản ứng). LOD của 04 thiết bị Realtime đều nằm trong khoảng 1-3xLOD so với LOD tham chiếu. Thông qua kết quả nghiên cứu cho thấy 04 hệ thống thiết bị Realtime PCR  đều cho kết quả tương đồng với nhau. Vì vậy, có thể sử dụng thay thế lẫn nhau trong 04 hệ thống thiết bị ABI7500; QuantStudioTM5; Hệ thống Realtime PCR CFX96 Touch Bio- Rad và abCyclerQ (AIT biotech) trong đánh giá chất lượng sinh phẩm chẩn đoán sử dụng kỹ thuật Realtime PCR.
THỰC TRẠNG PHÁT TRIỂN VÀ ỨNG DỤNG SINH PHẨM TƯƠNG TỰ TRONG Y HỌC HIỆN ĐẠI TỔNG QUAN QUY ĐỊNH CẤP LƯU HÀNH CỦA EMA VÀ FDA
Authors: Phạm Văn Hùng  , Đoàn Hữu Thiển  , Nguyễn Hoàng Tùng  , Nguyễn Văn Hùng  , Nguyễn Thị Vân Anh
Published: April 2023

Thị trường thuốc sinh phẩm tương tự phát triển và ứng dụng điều trị nhằm mục đích tăng cơ hội tiếp cận của bệnh nhân, giảm giá thành so với thuốc sinh phẩm tham chiếu gốc của nó. Nghiên cứu này tập trung phân tích thực trạng lộ trình nghiên cứu phát triển sinh phẩm tương tự của Châu Âu (EU) và Hoa Kỳ (US) và quá trình hoàn thiện các qui định, hướng dẫn luật đăng ký, cấp phép, đánh giá phi lâm sàng và lâm sàng. Số liệu thu thập từ dữ liệu công bố của Cơ quan Dược phẩm Châu Âu (EMA) và Cơ quan Quản lý Thực phẩm và Dược phẩm Mỹ (FDA) về cập nhật phê duyệt cấp phép thuốc sinh phẩm tương tự trước tháng 4 năm 2020.. Trong hơn thập kỷ vừa qua (13 năm), EMA đã nhận được trên 60 đơn đăng ký cấp phép lưu hành cho thuốc sinh phẩm tương tự với trên 50 loại thuốc sinh phẩm tương tự đã được phê duyệt có sẵn trên thị trường Châu Âu (EU). Kể từ lần phê duyệt thuốc tương tự sinh học đầu tiên vào năm 2015, FDA đã cấp trên 25 phê duyệt cho thuốc sinh phẩm tương tự, chỉ có 11 loại hiện có trên thị trường Mỹ (US). Phân tích ví dụ điển hình cấp phép sinh phẩm tương tự, đánh giá phi lâm sàng và lâm sàng tại EMA và FDA của 5 sản phẩm thuốc tương tự sinh học adalimumab đã được thương mại hóa dưới dạng tám loại thuốc khác nhau thông qua các ủy quyền tiếp thị trùng lặp. Ba trong số này được FDA chấp thuận, thuốc tương tự sinh học adalimumab đầu tiên sẽ không được bán trên thị trường US cho đến năm 2023 do giai đoạn độc quyền của sinh phẩm tham chiếu gốc Humira.

Kết quả phân tích cho thấy: thị trường thuốc tương tự sinh học của EU đã phát triển nhanh hơn so với đối tác US với lý do bởi thời hạn độc quyền một loạt các bằng sáng chế và bảo vệ số liệu khoa học đánh giá thử nghiệm lâm sàng các loại thuốc sinh học tham chiếu gốc cũng đã được đề cập trong 'Kế hoạch hành động thuốc tương tự sinh học' mới nhất của US đã được công bố.
NGHIÊN CỨU XÂY DỰNG QUY TRÌNH KIỂM ĐỊNH CÔNG HIỆU BẠCH HẦU BẰNG PHƯƠNG PHÁP MIỄN DỊCH TRÊN CHUỘT NHẮT VÀ CHUẨN ĐỘ TRÊN TẾ BÀO VERO
Authors: Nguyễn Phương Liên  , Bùi Thị Kim Xuyến  , Lê Thị Hoàng Yến  , Đỗ Khánh Linh  , Nguyễn Thị Kim Ngân  , Ngô Thị Hoa
Published: April 2023

Vắc xin Bạch hầu được sử dụng trong chương trình tiêm chủng quốc gia đã góp phần thanh toán bệnh Bạch hầu cho trẻ em Việt Nam từ nhiều năm nay. Việc xác định công hiệu của vắc xin là vô cùng cần thiết để đảm bảo hiệu lực cuả từng lô sản phẩm được sử dụng ngoài thị trường. Hiện nay trên thế giới chỉ có mẫu chuẩn Bạch hầu tính trên đơn vị chuột lang, tuy nhiên việc sử dụng chuột lang quá nhiều gây khó khăn cho quá trình thực hiện. Khoa Vi khuẩn- Viện Kiểm định Quốc gia Vắc xin và Sinh phẩm y tế đã nghiên cứu và phát triển quy trình xác định công hiệu Bạch hầu trên chuột nhắt trắng, dòng chuột ICR. Nghiên cứu áp dụng quy trình kiểm định công hiệu Bạch hầu bằng phương pháp miễn dịch trên chuột nhắt, chuẩn độ trên tế bào Vero, thử nghiệm được thẩm định qua 5 lần thử nghiệm độc lập. Các lần thử nghiệm thực hiện song song với mẫu chuẩn quốc tế Bạch hầu (NIBSC) đã biết trước đơn vị công hiệu là 213 IU/ống cùng mẫu thử cần xác định giá trị. Kết quả của các lần thử nghiệm được sử dụng để đánh giá chất lượng vắc xin và thiết lập một quy trình thử nghiệm cho việc kiểm định chất lượng vắc xin bạch hầu.
Pengendalian Kualitas CPO untuk Meminimumkan ALB Menggunakan Metode DMAIC
Authors: Nasution Diko Ryanda , Hasibuan Abdurozzaq , Sibuea Siti Rahma
Published: April 2023

PT. Citra Sawit Lestari merupakan perusahaan yang bergerak dalam bidang produksi CPO. Perusahaan ini terus bersaing dengan perusahaan lain sehingga kualitas menjadi faktor yang sangat penting untuk bersaing dengan perusahaan lain. Pada penelitian ini bertujuan untuk mengidentifikasi faktor-faktor penyebab kanaikan kadar asam lemak bebas, yang melebihi standar untuk mengatasi permasalahan yaitu dengan menggunakan metode six sigma melalui pendekatan DMAIC (Define, Measure, Analize, Improve, Control). Berdasarkan hasil pengolahan data yang telah dilakukan mendefinisikan masalah standar kualitas dalam proses produksi dan berdasarkan perhitungan nilai Sigma, rata-rata tingkat Sigma x ̅ 2.102 dengan kemungkinan kerusakan sebesar 274000/dpmo untuk sejuta kali proses produksi (DPMO). Adapun perhitungan dengan diagram pareto yang memiliki persetase yaitu kadar asam lemak bebas 0,996%. Berdasarkan pengolahan data dapat diketahui penyebab cacat produk CPO yaitu bahan baku dikarenakan buah restan yang tinggi dan terjadinya penumpukan buah diruang penyimpanan terbuka. Faktor manusia dikarenakan kurang pelatihan dalam melakukan proses produksi. Faktor mesin dikarenakan mesin yang lambat panas dan kurangnya perawatan. Perbaikan untuk mengatasi permasalahan yaitu berupa pemeriksaan yang teliti dan terus-menerus terhadap mesin meningkatkan produktivitas produksi. Berdasarkan pengendalian kualitas bisa dikatakan bahwa perusahaan cukup memberikan manfaat dalam upaya mengurangi kegagalan produk akan tetapi belum maksimal. Sehingga perlu disarankan perusahaan meninggkatkan kapabilitas Sigma dan meningkatkan proses dengan cara melakukan perbaikan terhadap mesin, bahan baku, metode serta pembinaan dan pengawasan kerja karyawan.
Pengendalian Kualitas Curd Palm Oil Menggunakan Integrasi Metode Six Sigma-FMEA di PT Grahadura Leidong Prima
Authors: Sitompul Arifin Andreas , Zaharuddin Zaharuddin , Fazri Muhammad
Published: April 2023

Penelitian ini bertujuan untuk menerapkan konsep DMAIC dan FMEA untuk mengontrol kualitas minyak sawit mentah (CPO) dengan spesifikasi kadar asam lemak bebas, kadar air dan kadar kotoran. DMAIC adalah alat atau metode sistematis yang digunakan untuk perbaikan proses dan pengembangan produk berdasarkan metode statistik. FMEA digunakan untuk mengidentifikasi dan menganalisis potensi kegagalan untuk dilakukan perbaikan. Hasil penelitian menunjukkan masih terdapat data di luar batas spesifikasi, sehingga perlu dilakukan perbaikan. Dalam perhitungan kapasitas proses, terdapat nilai Cpk kurang dari 1 yang menunjukkan suatu proses menghasilkan produk di luar spesifikasi. Nilai sigma hasil pengukuran adalah 3,01. Akar penyebab menurunnya kualitas seperti tenaga kerja, bahan, mesin dan metode kemudian dianalisis menggunakan FMEA. Dari hasil FMEA didapatkan nilai RPN tertinggi yaitu 252 dan penyebab kegagalan adalah kualitas bahan baku yang kurang baik yang merupakan prioritas utama jenis kegagalan untuk segera dilakukan perbaikan. Usulan peningkatan kualitas produk dengan 5W+1H dengan memperbaiki semua faktor yang menyebabkan menurunnya kualitas dengan melakukan pelatihan terhadap kinerja dari tenaga kerja, meningkatkan mesin agar berfungsi optimal, dan bahkan memeriksa semua tingkat bahan baku karena produk diproduksi sesuai dengan spesifikasi perusahaan dan standar inspeksi, produk tersebut harus ditingkatkan secara teratur untuk menjaga stabilitas atas variasi proses.
Botulism in the 21st Century: A Scoping Review
Authors: Kobaidze Ketino , Wiley Zanthia
Published: April 2023

Botulism is a potentially deadly neuroparalytic disease that affects all age groups; it is highly challenging to diagnose due to its nonspecific symptoms. Infant botulism is the most common form of botulism in the United States, followed by foodborne and wound botulism. Since most patients require hospitalization, it is imperative that both adult and pediatric physicians recognize its symptoms. Patients with severe forms of botulism typically present early after toxin ingestion and progress rapidly. Although rare in the United States, botulism remains a public health concern since even one case may predict an outbreak. This review summarizes the typical clinical course of botulism and recommendations for diagnosis and management.
Patterns of Surgical Risk Assessment at a Tertiary Academic Medical Center
Authors: Murray John P , Tummala Sandeep , Chen Thomas , Aldrich Daniel , Reisner Alex , Martin Shannon K
Published: April 2023

Objective

Review preoperative risk stratification encounters performed by a hospital medicine consult service at a tertiary academic medical center to better characterize practice patterns and evaluate the need to standardize our approach to risk assessment.

Methods

Retrospective chart review of 200 randomly selected patients representing approximately 40% of all patients seen by the hospital medicine consult service from 2019-2020.

Results

Of the 200 charts reviewed, there were 71 preoperative risk assessments performed and 8 distinct approaches utilized. The most common risk stratification tool used was the Revised Cardiac Risk Index (RCRI), followed by the American College of Surgeons-Surgical Risk Calculator (ACS-SRC) and then the Gupta Myocardial Infarction and Cardiac Arrest calculator. 19 encounters (27%) used multiple risk stratification tools, while 11 encounters (15%) were not consistent with American College of Cardiology/American Heart Association guidelines.

Conclusion

Significant heterogeneity exists within preoperative risk stratification practices in this single-center study. Follow-up work remains to promote standardization in approach and documentation.
Diagnosing Functional Neurological Disorder through History and Physical Examination: A Case Report
Authors: Moore Jessica , Bijlani Sharan
Published: April 2023

Differentiating between stroke and stroke mimics (i.e., non-vascular conditions) is a major challenge, as they often involve similar presenting symptoms. A common type of stroke mimic is functional neurological disorder (FND), a somatic disorder caused by severe stress, emotional conflict, or a psychiatric disorder usually presenting with one or more neurologic symptoms. This condition is associated with voluntary motor and sensory symptoms that are internally inconsistent with identifiable neurological diseases and lack structural lesions. We describe a 54-year-old female with a history of transient ischemic attack resulting in bilateral blindness and recent social stressors, who presented with right-sided facial and extremity motor and sensory deficits, bilateral diplopia, and dysphagia. Her left upper and lower extremities had 2 out of 5 motor strength, a weak hand squeeze, and a positive Babinski reflex on the contralateral side of her weakness, which resolved the next day. In addition, decreased sensation to light touch and temperature over the right arm and leg were appreciated without a dermatomal pattern. Given the negative stroke work-up, atypical physical exam findings, prior history of blindness, and in the setting of recent psychological stressors, her acute motor and sensory deficits were diagnosed as FND after evaluation by the Neurology service. The current case demonstrates the following important features of making a FND diagnosis: 1) careful history taking in eliciting potential psychological stressors; 2) a comprehensive neurological examination assessing the presence of findings specific for FND (e.g., greater weakness with active rather than passive movements, fluctuating weakness); 3) multidisciplinary collaboration with neurology and psychiatry providers to aid in performing a comprehensive assessment.
Looking to the Past to Improve the Future: A Narrative Review of Lessons Learned from Inpatient Cardiac Arrest Care During the COVID-19 Pandemic
Authors: Shin Yoo Mee , Neurgaonkar Sneha , Nave Jessica , Hall Mary Ann Kirkconnell , Hunt Dan P. , Akwe Joyce
Published: April 2023

Background

Inpatient cardiac arrest care had to be adapted to meet the needs of patients and providers during the COVID-19 pandemic. Providers working in the emergency department and in the inpatient setting have acquired extensive experience and expertise in caring for patients with COVID-19 related cardiac arrest. We summarize recent reports relevant to clinicians on inpatient cardiac arrest care, provider and patient safety, and effective use of resources.

Methods

We performed literature searches of the PubMed database on inpatient cardiac arrest, COVID-19, healthcare-associated coronavirus transmission, and others. The authors’ collections of lived experience as inpatient care providers and clinically useful materials gathered during the pandemic were included.

Results

We summarize current knowledge about cardiac arrest in COVID-19 relevant to hospitalist practice, describe lessons learned to date, and provide practical guidance for addressing cardiopulmonary resuscitation for patients with COVID-19. We discuss literature on risk factors for cardiac arrest in patients with COVID-19; risk of infection for rescuers performing resuscitation in patients with COVID-19 and mitigation strategies; goals of care during cardiac arrest in a patient with COVID-19; reducing the risk of exposure to rescuers (including pre–cardiac arrest care); reducing cross-contamination during cardiac arrest in patients with COVID-19; prioritizing oxygenation and ventilation strategies with lower aerosolization risk; maximizing resources during cardiac arrest in patients with COVID-19; and post–cardiac arrest care.

Conclusions

Advances made in the care of inpatient cardiac arrest patients during the COVID-19 include domains of patient risk stratification, provider safety, advance directives, and others. Lessons in the management of inpatient cardiac arrest learned during this pandemic are likely to applicable to future pandemics.
Automatic Implantable Cardioverter Defibrillator Lead-related Endocarditis due to Staphylococcus lugdunensis
Authors: Thota Geethika , Joseph Betsy , Shah Monarch , Redel Henry , Yeruva Karthik R. , Patel Keval
Published: April 2023

Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CoNS) that constitutes normal skin flora and is often read as a contaminant when isolated in blood cultures. In recent years S. lugdunensis has been increasingly recognized as a true pathogen causing a spectrum of infections from benign skin and soft tissue infections to bacteremia, bone and joint infections, and endocarditis. A significant role in the pathogenesis of infections is played by the ability of the organism to form biofilms that allow it to attach itself to foreign objects such as pacemakers, prosthetic valves, and orthopedic implants. The mortality rate in infective endocarditis caused by S. lugdunensis has been as high as 38.8 % making it as virulent as Staphylococcus aureus reported in the literature. It requires aggressive antibiotics and optimal source control, including surgical debridement and valve replacement if indicated. We present a case of S.lugdunensis infective endocarditis in a patient with an automatic implantable cardioverter defibrillator (AICD). The patient presented with lower back pain for three weeks and was found to have a right psoas abscess and S.lugdunensis bacteremia, with a vegetation on the right ventricular defibrillator wire requiring device explantation and prolonged antibiotic treatment.
Survey on Awareness of COVID-19 Vaccination for General Population Residing in Pondicherry
Authors: Yasir Malik  , Kengadaran Shivashankar , Anusha Divvi
Published: April 2023

Introduction: Government of India has selected the priority groups who will be vaccinated on priority as they are at higher risk. The first group includes health-care workers because they are at high risk of contracting the infection and protecting them helps sustain essential health services. The vaccination of frontline workers will help in reducing the societal and economic impact by reducing COVID-19 mortalities. The next group to receive COVID-19 vaccine will be persons over 50 years of age and persons under 50 years with comorbid conditions because there is high mortality in this category. Therefore, the aim of the study is to assess the awareness of COVID-19 vaccination for general population residing in Pondicherry.

Materials and Methods: A questionnaire was prepared and sent using Google Forms through e-mail and WhatsApp and the participants were asked to submit the response. A total of 135 responses were received. Data were entered in Microsoft Excel sheet and then subjected to data analysis using SPSS software version 23. Descriptive statistics were expressed by means of frequency and percentage.

Results: About 80% of the participants were aware of the COVID-19 symptoms. 91.7% of the participants were very much aware that COVID 19 is a viral disease. Majority of them answered that COVID-19 vaccination may help them to defend infectious disease condition. 66.4% of them reported that vaccination could cause you adverse effect and 52.2% felt that only vaccination could help us from COVID-19 virus. Only 46.3% of the participants were willing to get vaccinated.

Conclusion: The present study shows that there is lack of appropriate awareness on COVID 19 vaccination among general population. People in Pondicherry are fear of adverse effect that causes by vaccination.
Patient Gratification and their Expectation from Dental Professionals- A Cross-Sectional Survey
Authors: R Shruthi
Published: April 2023

Introduction: Dentist attire has been molded by tradition and fashion over centuries. There have been many changes in thedental field and patient expectations and with increased proportion of female doctors entering the profession has led to changes in dentist dress code. White coats were worn by dentist for professionalism, identification and hygiene, yet white coats may be a source of, rather than a barrier to cross infection. Aim: The aim of this study is to assess the patients opinion toward dentist appearance, clinical attire, cross infection control, years of experience, and their expectations from their dentist.

Materials and Methods: Patients attending a dental hospital for a consultation appointment were asked to complete a close-ended questionnaire comprising 12 questions. A representative sample of patients completed 100 questionnaires over a period of 4 weeks. Their responses were tabulated and analyzed statistically.

Results: The study found that majority of patient preferred their own gender dentist and they preferred young dentist with 1–5 years of experience. Some patients preferred dentist wearing white coat while some patients were comfortable with whatever the dentist was wearing. The majority of patients preferred dentist wearing name badge and personal protective equipment. The majority of patients also preferred treatment from colleges and hospitals and preferred dentist who has done MDS/specialization. The majority of patients were more comfortable with dentist who is smiling, welcoming, and being friendly. Some patients preferred their dentist to talk more while some preferred their dentist to talk appropriately and few patients preferred their dentist to talk less. Dentist having long nails and malaligned or fractured teeth bothered some patient while it did not bother some patients and some patients did not notice it.

Conclusion: A considerable amount of research dealing with the professional image of health-care providers has been produced, but very little of this has been specific to the practice of dentistry. Hence, it is hoped that this study will be informative for dental team and the results should be taken into consideration.
Digital School Implementation at SMA Negeri 1 City of Sukabumi
Authors: Mulyana Rachmat , Hadian Tantan , Tejawiani Ida , Ikhwan Awaluddin Asep
Published: April 2023

Digital schools are essential for new experiences in the classroom and the education system as a whole for teachers and students, with the flood of new technologies, of course, demanding changes to the way teachers teach and learn students. This research aims to describe and analyze the implementation of digital school at SMAN 1 Sukabumi. This research uses a qualitative approach with a descriptive method. The respondents of this study were the principal, four deputy principals, teachers and 293 students. Data collection was carried out using documentation studies, observations, and interviews. The data obtained, collected, processed, and conclusions are drawn. The results of this study are that in school planning, this program has been planned to start in 2013 but has yet to have a grand design digital school program, both short-term and long-term. The organization of the program still needs to be directed. Meanwhile, in its implementation, SMA Negeri 1 Sukabumi has gradually implemented the digitization program. However, it still needs to be completed and comprehensive. The principal has carried out an internal evaluation. However, it still needs to evaluate the digital school program. Meanwhile, external supervision has yet to be carried out either by school committees or school supervisors. The school has planned a digital school program, with the formulation of the school's vision, mission and goals that lead to the development of a digital-based school. However, there must be a clear grand design for both short-term and long-term programs.
Analysis of Return on Investment Associated with Changes in Operational Time in the Construction of the Sigli-Banda Aceh Toll Road
Authors: Made Bayu Anggara I , Darma Yusria , Mubarak Mubarak
Published: April 2023

The problem with this research is that the government was late in land acquisition, so that PT. Hutama Karya (Persero) as the concession holder in the implementation of toll road construction is constrained in a number of locations. This study aims to determine the impact of delays in land acquisition and implementation of the construction of the Sigli-Banda Aceh Toll Road on net profit and return on investment at the end of the concession period. This study uses a quantitative method approach. Data analysis techniques use Present Net Value (NPV), Internal Rate of Return (IRR), and sensitivity analysis. The results of the study show that delays of 1, 2, and 3 years have an impact on concessionaires going through cash flow deficit periods of 17, 19, and 20 years and surplus cash flow periods of 23, 21, and 20 years. year, where investment returns occur in the 32nd (2050), 34th (2052) and 36th (2054) years, so that at the end of the concession period, the net profit that can be achieved by the concession holder is with an NPV value of Rp. 9,162,336,077,086, Rp. 6,858,784,951,438 and Rp. 4,680,164,756,915. If there are no delays, then the concessionaire only needs to go through a cash flow deficit period of 16 years and a cash flow surplus period of 24 years, where the return on investment capital occurs in year 30 (2048), so that the net profit that can be obtained by the concessionaire is with an NPV value of Rp. 11,647,590,651,181.
Traversal Using Relays Around Nat by Coturn for Webrtc Systems
Authors: Raswa Raswa , Lubis Ghozali Ahmad , Adi Cahyanto Kurnia
Published: April 2023

Real-time communication between people in the form of audio, images, video, and data is now a necessity. Web Real-Time Communication Technology, WebRTC, is implemented as an open web standard and is available to build such communication. WebRTC requires a server that functions as both signaling and media servers. Signaling server for establishing communication channels, exchanging information, and synchronizing changes. Media servers exchange media, codecs, bandwidth, and rate control. Different Real-time Protocol (RTP) topologies have different requirements on servers, including those caused by the NAT configuration used. This research focuses on the role of the TURN server using CoTurn to create web-based real-time communication services. How is the quality of WebRTC service when CoTurn is a TURN server to pass signaling and media. The method used is divided into three stages, namely: (1) installation and configuration, (2) building WebRTC, and (3) testing. This study shows that real-time communication in the form of audio and video can be carried out even through a symmetrical NAT configuration. It is just that with more than five users in the WebRTC system, communication is slowing down. The proposed further research is developing and engineering the RTP topology to increase the number of users. The CoTurn application can be installed on a Virtual Private Server (VPS) and configured as a TURN Server as a media server service in the WebRTC system.
The Influence of Self–Efficacy and Employee Empowerment on Organizational Citizenship Behavior through Job Satisfaction
Authors: Hermawati Rahmi , Moeins Anoesyirwan , Suhardi Eka
Published: April 2023

The purpose of this research is to form the minds of employees who have low self-efficacy so that they are more productive at work according to gender, age and workload. It also aims to identify and analyze the effect of self-efficacy and employee empowerment on civic organizational behaviour through job satisfaction. Research methodology with a qualitative type of library research. The results of the study are based on the results of the literature review analysis, including indicators of low self-efficacy, which are influenced by the failure to achieve employee welfare and no reward. A work system that is not conducive can influence employee loyalty and dedication to increase awareness at work, motivation, sense of responsibility, and quality in completing each work carried out within a predetermined time limit. Working professionally and loyally is a characteristic of employees who take their work seriously. High seriousness values for employees with maximum work performance can reduce the low self-efficacy of employees. Increasing self-efficacy and empowering employees can improve civic behaviour in organizations. Self-efficacy and employee empowerment help increase employees' self-confidence and abilities in carrying out their duties so that they can more effectively and efficiently contribute to the organization.
Application of integer linear program in optimizing convection sector production results using branch and bound method
Authors: Firmansah Fery , Yuwono Muhammad Ridlo , Munif Fika Aisyah
Published: April 2023

This study aimed to determine the application of the integer program in optimizing the production of the convection sector. Integer linear programming is a special form of linear programming in which the decision variable solutions are integers. Ayyumnah store as one part of the convection sectors with a home-scale does not have an appropriate strategy to optimize profits with limited materials owned. The method used in this study is an integer program with the branch and bound method. The result of this research is the optimal amount of production of long shirts and tunics at the Ayyumnah Store with maximum profit.
The Existence of the Iwadh Tradition in Strengthening the Relationship Between Congregations of Arabic Village in Manado
Authors: 'Ain Aufa Qutratu
Published: April 2023

Iwadh tradition is also important given to strengthen the relationship between congregation of Arabic Village in Manado. This phenomenological research aims to know the implementation of Iwadh Tradition reviewed from sociological approaches and to know the meaning of the implementation of Iwadh tradition in maintaining it’s existence and strengthening the silaturahim rope between pilgrims in Manado’s Arab Village. The participants in this research were one of the community leaders and Imam of the Masyhur Istiqlal Mosque in Manado Arab Village. This mini research conducted by the researcher uses a qualitative research type with a sociological approach. The results found that iwadh tradition known as the concept of close brotherhood, which has developed and become a symbol for the Arab Village community in the social sphere of the Manado City community, which is marked by the involvement of people from other villages or even urban villages who participate in and enliven the tradition encouraging Iwadh, so that it can strengthen the relationship between followers of religions. There for, The iwadh tradition has a meaning as an expression of a servant's gratitude to Allah SWT with the completion of the fasting month of Ramadhan.
Contemporary Research Practices in Social Sciences with Artificial Intelligence, Data Mining and Machine Learning
Authors: Yavuz Özerk , Alpago Hasan , Çiçek Mehmet
Published: April 2023

In the last decade usage and application of Artificial Intelligence, Machine Learning and Data Mining in different disciplines as social sciences, Medical Sciences and Engineering gained momentum. Today with the help of decision support systems supported with these smart approaches and algorithms give decision makers several advantages. In this way more targeted and focused decisions with higher success rates can be maintained for a more sustainable economy and world. In this book, unique contributions of 3 distinguished Professors have been compiled with the aim of providing insights to the reader about several phenomena in social sciences blended with artificial intelligence, machine learning and data mining practices. Hope you enjoy.
With my warmest and kindest regards,
Professor Özerk Yavuz
Decline in Quality and Quantity of Sleep in Young Adults: The Need of the Hour
Authors: Goothy Sai S. K. , Twinkle Rajak  , Chakraborty Hirok , Choudhary Anita , V K Mahadik
Published: April 2023

letter to editor
Small Cell Neuroendocrine Carcinoma of Cervix: A Rare Case Report
Authors: Jain Kavita , Roy P K
Published: April 2023

Neuroendocrine neoplasms (NEN) are derived from endocrine cells and are very rarely seen in gynecological practice. Here we report a case of small cell neuroendocrine carcinoma (SCNEC) of cervix in a 45 year old married female who presented with history of menorrhagia. On gynecological examination, she had bulky uterus with a palpable non tender, hard nodule on posterior wall of cervix. Ultrasonogram of pelvis was reported as bulky ? adenomyotic uterus with 2.7x2.4x1.0cm well defined collection in fundal region of endometrium. She underwent total abdominal hysterectomy for abnormal uterine bleeding. Histopathology with immunohistochemical markers was reported as small cell neuroendocrine carcinoma (SCNEC) of cervix. This case is reported here for its rarity.
DYNAMICS OF SPA TOURISM STATISTICS IN SELECTED COUNTRIES OF CENTRAL AND EASTERN EUROPE
Authors: Čeperković Jelena , Čerović Slobodan
Published: April 2023

Spas were attracting visitors since ancient times. Study aims to monitor the changes in spa tourism statistics in the period of 2010-2020 for the selected countries of Central and Eastern Europe (Croatia, Hungary, Serbia and Slovenia), with particular attention given to the average development rate (ADR) and average growth rate (AGR), and overnight stays and an average length of stay. The reference to the consequences of the Covid-19 pandemic on overnight stays and an average length of stay was discussed as well. Moreover, upon analysis of the existing tourism data for the period of 2010-2020, prediction of the post-pandemic period (until 2023-2025) was also implemented with the use of a linear model. In addition, using the broad criteria of a four-night stay as a minimum stay for medical treatments, Serbia has shown the characteristics of a medical spa, while Slovenia and Croatia could be characterized as “wellness medical”, and finally Hungary was considered as a wellness spa destination.
CONSUMER ATTITUDES AND HABITS ABOUT PRODUCTS WITH GEOGRAPHICAL INDICATION IN SERBIA
Authors: Ćirić Miloš , Ćirić Ivana , Pivac Tatjana , Besermenji Snežana
Published: April 2023

To market products with geographical indications in the best possible way, it is necessary to examine the attitudes and habits of consumers. The subject of this paper is a survey on habits and attitudes of consumers about products with GI in Serbia. The aim of this paper is to examine the level of familiarity, attitudes, and habits of consumers, as well as to determine the knowledge and interest in these products. Citizens of Serbia participated in the research (n = 399). The methodology is based on a questionnaire that obtained the data that were processed via t-test statistical methods for independent samples, one-factor analysis of variance, the χ² test, and Pearson’s correlation coefficient. Based on the conducted research, it can be stated that about 70% of respondents are willing to pay a higher price for these products.
Investigation of the combination of intratumoral and peritumoral radiomic signatures for predicting epidermal growth factor receptor mutation in lung adenocarcinoma
Authors: Kawazoe Yusuke , Shiinoki Takehiro , Fujimoto Koya , Yuasa Yuki , Hirano Tsunahiko , Matsunaga Kazuto , Tanaka Hidekazu
Published: April 2023

Purpose

We investigated optimal peritumoral size and constructed predictive models for epidermal growth factor receptor (EGFR) mutation.

Methods

A total of 164 patients with lung adenocarcinoma were retrospectively analyzed. Radiomic signatures for the intratumoral region and combinations of intratumoral and peritumoral regions (3, 5, and 7 mm) from computed tomography images were extracted using analysis of variance and least absolute shrinkage. The optimal peritumoral region was determined by radiomics score (rad‐score). Intratumoral radiomic signatures with clinical features (IRS) were used to construct predictive models for EGFR mutation. Combinations of intratumoral and 3, 5, or 7 mm‐peritumoral signatures with clinical features (IPRS3, IPRS5, and IPRS7, respectively) were also used to construct predictive models. Support vector machine (SVM), logistic regression (LR), and LightGBM models with five‐fold cross‐validation were constructed, and the receiver operating characteristics were evaluated. Area under the curve (AUC) of the training and test cohorts values were calculated. Brier scores (BS) and decision curve analysis (DCA) were used to evaluate the predictive models.

Results

The AUC values of the SVM, LR, and LightGBM models derived from IRS were 0.783 (95% confidence interval: 0.602–0.956), 0.789 (0.654–0.927), and 0.735 (0.613–0.958) for training, and 0.791 (0.641–0.920), 0.781 (0.538–0.930), and 0.734 (0.538–0.930) for test cohort, respectively. Rad‐score confirmed that the 3 mm‐peritumoral size was optimal (IPRS3), and AUCs values of SVM, LR, and lightGBM models derived from IPRS3 were 0.831 (0.666–0.984), 0.804 (0.622–0.908), and 0.769 (0.628–0.921) for training and 0.765 (0.644–0.921), 0.783 (0.583–0.921), and 0.796 (0.583–0.949) for test cohort, respectively. The BS and DCA of the LR and LightGBM models derived from IPRS3 were better than those from IRS.

Conclusion

Accordingly, the combination of intratumoral and 3 mm‐peritumoral radiomic signatures may be helpful for predicting EGFR mutations.
Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait
Authors: Gan Caiting , Cao Xingyue , Wang Lina , Sun Huimin , Ji Min , Zhang Heng , Yuan Yongsheng , Zhang Kezhong
Published: March 2023

Background

Mounting research support that cholinergic dysfunction plays a prominent role in freezing of gait (FOG), which commonly occurs in Parkinson's disease (PD). Basal forebrain (BF), especially the cholinergic nuclei 4 (Ch4), provides the primary source of the brain cholinergic input. However, whether the degeneration of BF and its innervated cortex contribute to the pathogenesis of FOG is unknown.

Objective

To explore the role of structural alterations of BF and its innervated cortical brain regions in the pathogenesis of PD patients with freezing.

Methods

Magnetic resonance imaging assessments and neurological assessments were performed on 20 PD patients with FOG (PD‐FOG), 20 without FOG (PD‐NFOG), and 21 healthy participants. Subregion volumes of the BF were compared among groups. Local gyrification index (LGI) was computed to reveal the cortical alternations. Relationships among subregional BF volumes, LGI, and the severity of FOG were evaluated by multiple linear regression.

Results

Our study discovered that, compared to PD‐NFOG, PD‐FOG exhibited significant Ch4 atrophy (p = 4.6 × 10−5), accompanied by decreased LGI values in the left entorhinal cortex (p = 3.00 × 10−5) and parahippocampal gyrus (p = 2.90 × 10−5). Based on the regression analysis, Ch4 volume was negatively associated with FOG severity in PD‐FOG group (β = −12.224, T = −2.556, p = 0.031).

Interpretation

Our results imply that Ch4 degeneration and microstructural disorganization of its innervated cortical brain regions may play important roles in PD‐FOG.
From CO2 to Electricity: Photosynthesis‐Based Functionally Cooperating Mini‐Generator
Authors: Wang Dan , Wang Jiamin , Ming Rui , Liu Chongxian , Tian Pan , Cheng Mengjiao , Xiao Meng , Shi Feng
Published: April 2023

Recently, the global warming and climate changes have aroused focus of attentions. Hence, there is an increased demand to capture, utilize, and sequestrate the greenhouse gas, i.e., carbon dioxide (CO2), for promising applications. Functionally cooperating mini‐generators are a kind of self‐propelled smart devices that can harvest environmental energy and convert it to electricity through Faraday's law. But traditional mini‐generators are based on an energy‐consuming process appealing for energy consumption from high‐grade state to low‐grade one. Herein, a mini‐generator based on photosynthesis with CO2 as the fuel is designed. The generator can convert the internal energy of O2 bubbles produced by photosynthesis to electricity. This is an energy conversion from the lowest energy state to the applicable energy. Based on the high‐efficiency photosynthesis of hydrophyte, spontaneously water‐dissolved CO2 can afford to induce regularly cycled surfacing‐diving motion, and the induced electrical output can simultaneously actuate multiple electronic components. Owing to the weather sensitivity of the photosynthesis, the system can be used to monitor weather through reading the changes of output electrical signals. By integrating the artificial smart device with natural plants, this research will promote the applications of miniaturized devices toward green development.
Bacteria‐Targeted Combined with Photothermal/NO Nanoparticles for the Treatment and Diagnosis of MRSA Infection In Vivo
Authors: Lv Kai , Li Guowei , Pan Xiangjun , Liu Luxuan , Chen Ziheng , Zhang Yu , Xu Hao , Ma Dong
Published: April 2023

Currently, undeveloped diagnosis and delayed treatment of bacteria‐infected sites in vivo not only expand the risk of tissue infection but are also a major clinical cause of multiple drug‐resistant bacterial infections. Herein, an efficient nanoplatform for near‐infrared (NIR)‐light‐controlled release and bacteria‐targeted delivery of nitric oxide (NO) combined with photothermal therapy (PTT) is presented. Using maltotriose‐decorated mesoporous polydopamine (MPDA‐Mal) and BNN6, a smart antibacterial (B@MPDA‐Mal) is developed to combine bacterial targeting, gas‐controlled release, and PTT. Utilizing bacteria's unique maltodextrin transport system, B@MPDA‐Mal can accurately distinguish bacterial infection from sterile inflammation and target the bacteria‐infected sites for efficient drug enrichment. Moreover, NIR‐light causes MPDA to generate heat, which not only effectively induces BNN6 to produce NO, but also raises the temperature to harm the bacteria further. NO/photothermal combination therapy effectively eliminates biofilm and drug‐resistant bacteria. The myositis model of methicillin‐resistant Staphylococcus aureus infection is established and indicates that B@MPDA‐Mal can successfully eradicate inflammation and abscesses in mice. Meanwhile, magnetic resonance imaging technology is used to monitor the treatment procedure and healing outcomes. Given the aforementioned advantages, the smart antibacterial nanoplatform B@MPDA‐Mal can be used as a potential therapeutic tool in the biomedical field against drug‐resistant bacterial infections.
Biomimetic Spun Silk Ionotronic Fibers for Intelligent Discrimination of Motions and Tactile Stimuli
Authors: Cao Xinyi , Ye Chao , Cao Leitao , Shan Yicheng , Ren Jing , Ling Shengjie
Published: April 2023

Innovation in the ionotronics field has significantly accelerated the development of ultraflexible devices and machines. However, it is still challenging to develop efficient ionotronic‐based fibers with necessary stretchability, resilience, and conductivity due to inherent conflict in producing spinning dopes with both high polymer and ion concentrations and low viscosities. Inspired by the liquid crystalline spinning of animal silk, this study circumvents the inherent tradeoff in other spinning methods by dry spinning a nematic silk microfibril dope solution. The liquid crystalline texture allows the spinning dope to flow through the spinneret and form free‐standing fibers under minimal external forces. The resultant silk‐sourced ionotronic fibers (SSIFs) are highly stretchable, tough, resilient, and fatigue‐resistant. These mechanical advantages ensure a rapid and recoverable electromechanical response of SSIFs to kinematic deformations. Further, the incorporation of SSIFs into core–shell triboelectric nanogenerator fibers provides outstanding stable and sensitive triboelectric response to precisely and sensitively perceive small pressures. Moreover, by implementing a combination of machine learning and Internet of Things techniques, the SSIFs can sort objects made of different materials. With these structural, processing, performance, and functional merits, the SSIFs prepared herein are expected to be applied in human–machine interfaces.
Clearwing‐Inspired Invisible Thin Membrane
Authors: Kang Seong Min , Choi Ji Seong , Hong Jongwoo , Lee Ok Hyeon , Kang Insun
Published: March 2023

Advanced highly transparent films or membranes are required for diverse optical applications, including ophthalmology and the display industry. In general, bioinspired engineering is the most promising technology for obtaining highly transparent surfaces. This study proposes a novel perfluoropolyether (PFPE) highly transparent thin membrane with nanopatterns on both sides of the surface, inspired by the wings (clearwing) of Greta‐oto. PFPE is a superior material for achieving this goal because of its low refractive index and low surface energy. A clearwing‐inspired antireflective membrane (CAM) composed of PFPE is fabricated using a well‐designed polymer replica method. CAM exhibits outstanding optical properties and intriguing demonstrations of invisible trap sensors, both in air and water, with long‐term stability.