bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Cystoisospora suis sexual stages in vitro
Authors: Feix Anna Sophia , Cruz-Bustos Teresa , Ruttkowski Bärbel , Joachim Anja
Published: December 2019

Background: The porcine coccidium Cystoisospora suis is characterized by a complex life cycle during which asexual multiplication is followed by sexual development with two morphologically distinct cell types, the micro- and macrogametes. Genes related to the sexual stages and cell cycle progression were previously identified in related Apicomplexa. Here, the sexual stages of C. suis were characterized in vitro morphologically and for temporal expression changes of the mentioned genes to gain insight into this poorly known phase of coccidian development.Methods: Sexual stages of C. suis (micro- and macrogametes) developing in vitro in porcine intestinal epithelial cells were examined by light and electron microscopy. The transcriptional levels of genes related to merozoite multiplication and sexual development were evaluated by quantitative real-time PCR at different time points of cultivation. Dynein light chain type 1 and male gamete fusion factor HAP2 expression is presumably restricted to microgametes. Tyrosin-rich proteins are a part of the wall-forming bodies and oocyst wall proteins. The RAD51/Dmc1 protein plays a role during the cell division process, and Nima-related protein kinases regulate the cell cycle and are associated with male or female Plasmodium gametocytes. Transcription levels were compared for parasites in culture supernatants at 6–9 doc (day of cultivation) and intracellular parasites at 6–15 doc.Results: Sexual stage of C. suis could be found during 8–11 doc in vitro. Microgametes had a spherical body (3.0–5.0 µm) and two flagella (10.8–12.3 µm). Macrogametes were spherical with a diameter of 11.5–13.0 µm. Merozoite gene transcription peaked on 10 doc and then declined. Genes related to the sexual stages and cell cycle showed an upregulation with a peak on 13 doc, after which they declined. Conclusions: The present work linked gene expression changes to the detailed morphological description of C. suis sexual development in vitro, including fertilization, meiosis and oocyst formation in vitro. Following this process at the cellular and molecular level will elucidate details on potential bottlenecks of development of C. suis (and coccidian parasites in general) which could be exploited as novel targets for control.
De novo assembly of Amorpha fruticosa (Amorpha fruticosa L.) transcriptome in response to drought stress provides insight into the tolerance mechanisms
Authors: SUN Xinzhu , LIU He , HU Songmiao , ZHOU Yunwei , GUAN Qingjie
Published: December 2019

Background Amorpha fruticosa (Amorpha fruticosa L.) is a deciduous shrub that is native to North America and has been introduced to China as an ornamental plant.In order to cultivate drought-tolerant Amorpha fruticosa varieties, it is important to understand the drought-tolerant mechanism of Amorpha fruticosa. Through the changes of the transcriptome of Amorpha fruticosa under drought stress, the mechanism of anti-stress of Amorpha fruticosa could be revealed. Different concentrations of polyethylene glycol-6000 (PEG-6000) was used to simulate drought stress, and transcriptomic analysis was used to reveal the changes of gene expression patterns in Amorpha fruticosa seedlings.Results Results showed that Amorpha fruticosa seedlings were seriously affected by PEG-6000. As for the differently expressed genes (DEGs), most of them were up-regulated. The additional Go and KEGG analysis results showed that DEGs were functionally enriched in cell wall, signal transduction and hormonal regulation related pathways. DEGs like AfSOD, AfHSP, AfTGA, AfbZIP and AfGRX play roles in response to drought stress.Conclusion In conclusion, Amorpha fruticosa seedlings were sensitive to drought, which was different from Amorpha fruticosa tree, and the genes functions in drought stress responses via ABA‐independent pathways. The up-regulation of Salicylic acid signal related DEGs (AfTGA and AfPR-1) indicated that Amorpha fruticosa can resist drought stress through Salicylic acid.
Community Based Review, Implementation, and Evaluation of Nutrition Course plan in the Doctorate of Medicine and Baccalaureate of Nursing by Nutritional Need Assessment
Authors: Naghashpour Mahshid , Amini Mitra , Khaleghjoo Armin , Khanzadeh Abdollah , Zahedi Atefe , Fakharzadeh Leila , Golabi Sahar , Mansouri Samaneh , Adelipour Maryam
Published: December 2019

Background: Training needs assessment is the process of identifying educational needs. The project aims to determine the priorities of nutrition-related health problems in the Southwest of Iran through training needs assessment. This process designed to review the nutrition course plan based on the community needs, implementation, and evaluation to identify the potential strengths and weaknesses of the considered course plan from the students’ perspectives. Methods: The study was designed in five phases: 1) needs assessment by using Nominal Group Technique, 2) review of nutrition course plan, 3) implementation of revised nutrition course plan, 4) qualitative evaluation of the new course plan by students, and 5) comparison of the grade of the students in the new course by students in the previous course. Behavioral and non-behavioral causes of the nutrition-related health problem priorities were determined using the nominal group technique. A review of the nutrition course plan was done. A revised course plan was implemented for medical and nursing students in two semesters. A conventional content analysis was applied to analyze the qualitative data obtained from the students' semi-structured interviews. The mean of semester exam scores was compared between the students trained with the revised course plan and the previous one by one-way ANOVA.Results: The conventional content analysis identified three major themes: perfect educational content, shortcomings, and strategies. Medical students trained with the revised course plan in the first semester obtained a higher semester exam score compared to the students trained with a revised course plan in the second semester. Also, semester exam scores were higher among nursing students trained with the previous course plan compared to the students trained with the revised one (p<0.05). Conclusions: Needs assessment provides an opportunity for a community-based review of the nutrition course plan. Evaluation of the implementation of the revised course plan allowed the students to state experiential learning that enables them to identify the educational needs as future employees and explore shortcomings and strategies to improve the medical education programs.
Evolutionary engineering improved D-glucose/xylose co-fermentation of Yarrowia lipolytica
Authors: Zhou Linlin , Wen Zhiqiang , Wang Zedi , Zhang Yuwei , Ledesma-Amaro Rodrigo , Jin Mingjie
Published: December 2019

Background: Yarrowia lipolytica is considered as a promising biorefinery chassis for production of microbial lipids, the important precursors of advanced biofuels. Unfortunately, wild Yarrowia lipolytica is unable to consume xylose, the major pentose in lignocellulosic hydrolysates. A recombinant strain Yarrowia lipolytica yl-XYL+ can utilize xylose to produce microbial lipids efficiently, but its xylose uptake is severely delayed in the presentence of D-glucose. Therefore, it is critical to develop co-fermenting D-glucose and xylose strains and study the underlying mechanisms.Results: In this study, an adaptive laboratory evolution (ALE) is performed to engineering the strains in the medium containing xylose and D-glucose analog 2-deoxyglucose (dG). After four stages of evolution over a total of 64 days, we obtained for the first time a strain of Y. lipolytica (yl-XYL+*04*10) with derepressed xylose metabolism. Xylose uptake kinetics showed that it could efficiently utilize xylose in the presence of 10 g/L dG or D-glucose. Transcriptional profiling analysis revealed that relative expression level of YALI0_C04730g and YALI0_D00363g (both encoding xylose-specific transporter) was significantly up-regulated. Besides, we found that missense mutations N373T and G270A in YALI0_E23287g (encoding a D-glucose transporter) and YALI0_E15488g (encoding a hexokinase) respectively.Conclusions: These results indicate that these are important gene targets responsible for improved xylose utilization in the evolved Yarrowia lipolytica. Our work provides a new approach for breeding Yarrowia lipolytica and paved the way for future pentose metabolic engineering.
DA RELATIVIZAÇÃO ANÔMALA DA COISA JULGADA COM A SUPERAÇÃO DO PRECEDENTE JUDICIAL
Authors: Dias Norton Maldonado , Ribeiro Rafael
Published: December 2019

Trata-se de um estudo acerca da possibilidade da relativização atípica da coisa julgada quando ignoradas as condicionantes de fato para superação do precedente. Com a vigência do CPC/2015 se tornou mais nítida a presença do sistema de precedentes (stare decisis) no direito brasileiro como forma de garantir a estabilidade das decisões judiciais. Entretanto, a renovação do entendimento consolidado, embora aparente ser desfavorável à estabilidade do precedente, também é forma de preservar a expectativa do particular. Ocorre que por vezes, o precedente é superado sem que esteja em desconformidade com a realidade social, em outras palavras, sem observância às condicionantes de fato, pressupostos que legitimam a renovação do entendimento. A problemática surge quando a decisão maculada por este vício transita em julgado e se torna imutável ad eternum, tendo em vista a inexistência de previsão legal que autorize sua desconstituição. O presente trabalho pretende, a partir de uma exposição suficiente para a compreensão do tema, responder a seguinte questão: há possibilidade de revisar a coisa julgada por meio da ação rescisória quando a sentença ou acórdão se pautarem exclusivamente em um precedente judicial superado sem observância às condicionantes de fato?
UNIVERSALIDADE DOS DIREITOS HUMANOS E DIVERSIDADE CULTURAL: O DIÁLOGO INTERCULTURAL COMO MEIO DE PRESERVAÇÃO DA IDENTIDADE E AUTONOMIA DOS POVOS INDÍGENAS
Authors: Jank Calixto Angela , Coimbra de Carvalho Luciani
Published: December 2019

A afirmação da universalidade dos direitos humanos depende necessariamente da observância à diversidade cultural existente. No âmbito local, destaca-se que o reconhecimento da identidade cultural dos povos indígenas constitui questão de essencial importância para se assegurar referida diversidade e para o estabelecimento de uma relação harmoniosa entre direitos humanos e o direito costumeiro indígena. Entretanto, diante da tensão existente entre algumas práticas tradicionais indígenas e direitos humanos, denota-se a necessidade de adoção de uma postura dialógica pelos tribunais internacionais e estatais com as comunidades locais, para superar a resistência à aceitação da diversidade cultural indígena. Ante a relevância de se identificar o diálogo como meio para a construção de um universalismo consciente das diferenças, procura-se com esse trabalho delimitar como o diálogo intercultural tem se firmado na América Latina e demonstrar os rumos para a coexistência do direito estatal e internacional com o direito local das comunidades indígenas.
A EFETIVIDADE DA LIBERDADE RELIGIOSA COMO UM DIREITO FUNDAMENTAL
Authors: Silveira Daniel Barile da , Fachini Elaine
Published: December 2019

Consagrado no artigo 5º da Constituição Federal de 1988, os direitos fundamentais, elencados pelo princípio da dignidade da pessoa humana, atuam como fundamento do Estado Democrático de Direito, porém, somente efetivos é que se tornam concretos na vida da sociedade. Objetiva-se, através desse artigo, ponderar sobre os direitos fundamentais e sua efetividade, como o direito fundamental à liberdade religiosa, especialmente em como são implementados no ordenamento jurídico pátrio, verificando o tratamento dado à temática pelo judiciário nacional, sempre considerando a laicidade do Estado brasileiro. Sendo assim, justifica-se o pressente pela relevância e contemporaneidade do tema, pela busca do equilíbrio da garantia à liberdade religiosa como um direito fundamental, analisando também o recente julgado referente ao ensino religioso, a ADI 4439/2010. Para tanto, utilizaremos a metodologia hipotético-dedutiva, qualitativamente, colhidas em bibliografias e jurisprudência pertinentes ao assunto em questão. Conclui-se que o direito fundamental à liberdade religiosa e sua efetivação é dever do Estado, pois a ele cabe assegurar um direito igualitário de escolha e que, por ser laico, não deve ter atitudes de favorecimento de uma ou algumas religiões, para não ferir o postulado na Constituição Federal, garantindo assim, o direito fundamental à liberdade religiosa e a dignidade da pessoa em escolher sua religião ou crença.
ENTRE MUROS: A VINCULATIVIDADE JUDICIAL VS. O PRINCÍPIO DA INDEPENDÊNCIA DOS TRIBUNAIS
Authors: Staack André Luiz
Published: December 2019

Este artigo objetivou identificar a melhor a relação entre a vinculatividade judicial e o princípio da independência dos tribunais. Para o alcance do objetivo proposto, o método de abordagem foi o indutivo, sendo o levantamento de dados realizado através da técnica da pesquisa bibliográfica de fonte secundária. Nas considerações finais, concluiu-se que a melhor relação entre a vinculatividade judicial e o princípio da independência dos tribunais, resta estabelecida no modelo português, já que ela permite ao magistrado uma ampliação de sua percepção imaginativa e, por consequência, auxilia na formação de um direito mais coerente.
OS DIREITOS HUMANOS, A MULTICULTURALIDADE E O RISCO DO CHOQUE DE CIVILIZAÇÕES: UMA ANÁLISE DO MUNDO PÓS-GUERRA FRIA
Authors: Bedin Gilmar Antonio , Felzke Schonardie Elenise , Pedron Leves Aline Michele
Published: December 2019

O presente tem como objetivo examinar, no mundo pós-guerra fria, a emergência da globalização e os riscos de choque de civilizações daí decorrentes. Partindo do pressuposto de que o direito e a história sempre estiveram algum nível de conexão, nota-se que as transformações do pós-segunda Guerra mundial e os processos decorrentes do fenômeno da globalização tornaram mais evidente esse processo e que, em consequência, potencializaram os riscos de conflitos de grande intensidade e violação dos direitos humanos. Nesse sentido, torna-se evidente o questionamento acerca de como é possível superar os impasses, os choques ou os conflitos resultantes das aproximações entre as civilizações de culturas e identidades heterogêneas e, assim, avançar na construção de uma sociedade internacional pacífica e coesa. Para tanto, são analisadas, mediante a utilização do método hipotético-dedutivo e da técnica de pesquisa bibliográfica, com aporte teórico-sociológico nas obras de Ulrich Beck e Samuel Huntington, as interseções da sociedade de risco e a interdependência multicultural que se estabelece na nova estrutura da ordem mundial. Com efeito, muitos povos se entrechocam uns com os outros em virtude de suas culturas e ideologias distintas, fato esse que coloca em xeque os parâmetros soberania estatal e contribui para que se acentuem os problemas, a fragmentação e o ressurgimento de racismos, nacionalismos e fundamentalismos. Em consequência, torna-se necessária a ampliação das iniciativas fortalecem o diálogo entre as diferentes culturas existentes e a proteção internacional dos direitos humanos.
No-ser, falsedad y contradicción: la segunda demostración erística del Eutidemo y el problema de lo falso en el Sofista
Authors: Villar Francisco
Published: December 2019

Este trabajo realiza una lectura de Eutidemo 283c-288b a la luz del problema de la falsedad en el Sofista. Mi hipótesis será que la segunda demostración erística del Eutidemo puede ser interpretada como una representación de Sofista 236d-239b: mientras que allí es el Extranjero el que evoca lo que el sofista diría para defenderse de la séptima definición, donde se lo acusa de producir falsedades, en el Eutidemo son dos sofistas quienes emplean las nociones de no-ser y falsedad para refutar dicha acusación. La exposición tendrá tres partes. En la primera analizaré Sofista 236d-239b y lo contextualizaré en el marco de la séptima definición. En la segunda me concentraré en la caracterización de Eutidemo y Dionisodoro en tanto sofistas. En la tercera analizaré los tres argumentos que organizan la segunda demostración del Eutidemo, intentando dar cuenta de su estructura y su rol en la economía dramática del diálogo.
La ciencia en la posmodernidad: el caso de Rorty y Lyotard
Authors: Hernández Cornejo Nalliely
Published: December 2019

El objetivo de este trabajo consiste en contrastar las concepciones sobre la ciencia que desarrollan el filósofo norteamericano Richard Rorty y el filósofo francés Jean-François Lyotard en algunos de sus textos más conocidos. Para ello, primero mostraremos un panorama general del pensamiento posmoderno dentro del cual se ubican las propuestas de estos dos autores. A continuación, señalaremos algunos puntos de convergencia en sus respectivas perspectivas filosóficas y, en particular, epistémicas, para después señalar claras diferencias en su construcción filosófica de lo científico, su desarrollo y función social. Finalmente, intentaremos defender brevemente que la perspectiva de Rorty resulta más adecuada que la del francés de cara a enfrentar los retos actuales de la ciencia y para dar cuenta de su desarrollo histórico, pero que dicha perspectiva puede ser complementada y enriquecida por la crítica económica y política de éste último.
Estrategias de modelización en Alan Turing: términos y conceptos de máquina
Authors: Ilcic Andrés , García Pío
Published: December 2019

Como es bien conocido, en 1936 Alan Turing propuso sus máquinas automáticas como modelo de la computación realizada por un ser humano asistido sólo con recursos mecánicos. Sin embargo, tanto terminológicamente como conceptualmente habría más para decir acerca de la concepción de máquina en la obra de Turing. En el presente trabajo presentamos términos que, a nuestro entender, son relevantes para dar cuenta de las preocupaciones y problemas que Turing abordó luego de la propuesta inicial de fines de los años treinta. En el uso de dichos términos trataremos de mostrar la ampliación o extensión de la noción de máquina en general a partir de la de “máquina automática”. A su vez, identificamos en su obra una intención o actitudmodeladora en el que las máquinas se pueden usar como una forma de entender y explicar un fenómeno natural o abstracto.
La especie que somos. Thomas Reid como precursor de la coevolución genocultural
Authors: Prado José Hernández
Published: December 2019

Thomas Reid (1710-1796) fue un filósofo ilustrado escocés que delineó una concepción muy rica y completa de la naturaleza humana, para concluir que ésta es muy especial. Si bien pudo haberse llegado a esta naturaleza por mera evolución biológica y conductual, al ser ella tan especial, no cabe duda de que su evolución también habría continuado de manera muy peculiar; un modo que plausiblemente daría lugar a la coevolución genocultural tan reivindicada por los estudiosos actuales de la naturaleza humana. Reid es, por consiguiente, un claro precursor de las teorías en torno a dicha coevolución.
“YAPAY” BİR ÇOCUK KORUMA MODELİ OLARAK SOS ÇOCUK KÖYLERİ VE TÜRKİYE’DEKİ UYGULAMALARI
Authors: YAMAN Fikret
Published: December 2019

Aile,
çocukların büyümeleri için doğal ve ideal ortam olmasına rağmen bazı çocuklar çeşitli
nedenlerle aile bakımından yoksun yaşamak zorunda kalmaktadır.  Uluslararası ve ulusal mevzuata göre, ebeveyn
bakımından yoksun olan korunmaya muhtaç çocukların tespiti, korunması ve alternatif
hizmet modellerinden faydalandırılması kamunun sorumluluğundadır. Bununla
birlikte, kamu kurumlarının yanı sıra korunmaya muhtaç çocuklara küresel
ölçekte hizmet sunan sivil toplum örgütleri de bulunmaktadır.

    Bu çalışmada, ebeveyn bakımından
yoksun çocuklara dünya genelinde hizmet sunan sivil toplum örgütlerinden biri
olan Uluslararası SOS Çocuk Köylerinin korunmaya muhtaç çocuklara yönelik
hizmetleri, kuruluş modeli ve Türkiye’deki uygulamaları eleştirel bir
yaklaşımla ele alınacaktır.        Uluslararası
SOS çocuk köyü modeli “anne, kız ve erkek kardeşler, ev ve köy” olmak üzere
dört bileşenden oluşmaktadır. Uluslararası SOS, bu model ile ebeveyn bakımından
yoksun çocuklara “gerçek” bir aile ortamı oluşturduğunu iddia etmektedir. Uluslararası
SOS, 2017 yılı sonu itibariyle Afrika, Amerika, Asya ve Okyanusya ve Avrupa’da 572
Çocuk Köyü ile 81.700 çocuk ve gence hizmet vermeye devam etmektedir.        Uluslararası
Çocuk Köylerini eleştirel bir yaklaşım ve çocuk hakları perspektifinden ele
alan bu çalışmanın,  SOS Çocuk Koruma
modellerinin daha iyi anlaşılmasına ve çocuk refahı alanındaki çalışmalara katkı
sağlanması beklenmektedir.
KADINLARIN BENLİK İKİLEMLERİ İLE BÜTÜNLEYİCİ KENDİLİK FARKINDALIKLARININ ÇEŞİTLİ DEĞİŞKENLER AÇISINDAN İNCELENMESİ
Authors: UYGUR Sebahat Sevgi , ASICI Esra , SARI Derya
Published: December 2019

Bu araştırmada, kadınların benlik ikilemi ile
bütünleyici kendilik farkındalık düzeyleri arasındaki ilişkinin incelenmesi
amaçlanmıştır. Ayrıca kadınların benlik ikilemiyle bütünleyici kendilik
farkındalık düzeylerinin psikolojik sorun yaşama, psikolojik yardım alma,
medeni durum, yerleşim yeri ve aylık gelir değişkenlerine göre farklılaşıp
farklılaşmadığı incelenmiştir. Araştırma, betimsel tarama modelinde bir çalışmadır.
Veriler online olarak kartopu örnekleme yöntemiyle toplanmıştır.  Araştırmaya 274’ü bekar, 107’si evli olmak
üzere 382 kadın katılmıştır. Veri toplama araçları olarak Kişisel Bilgi Formu,
Benlik İkilemi Ölçeği, Bütünleyici Kendilik Farkındalığı Ölçeği kullanılmıştır.
Çalışmada Pearson Korelasyonu, Tek Yönlü ANOVA, Bağımsız Gruplar için t Testi
uygulanmıştır. Araştırma bulguları; kadınların benlik ikilemi ile bütünleyici
kendilik farkındalığı puanları arasında negatif yönde anlamlı ilişki olduğunu
ortaya koymuştur. Psikolojik sorun yaşama ve medeni duruma göre, kadınların
benlik ikilemi toplam ve benlik ikilemi alt boyut puanları arasında
istatistiksel olarak anlamlı farklılık olduğu görülürken; hayatın büyük
bölümünün geçirildiği yerleşim yerine göre, bütünleyici kendilik farkındalığı
puanları arasında;  aylık gelire göre,
bütünleyici kendilik farkındalığı ve sosyal kabul edilebilirlik ikilemi
puanları arasında ve psikolojik yardım alma durumuna göre, değerlilik ikilemi puanları arasında anlamlı farklılık olduğu
saptanmıştır. Elde edilen bulgular, ilgili literatür ışığında tartışılmıştır.
Hydrogen production from coffee pulp by dark fermentation
Authors: Miñón-Fuentes Raciel , Aguilar-Juárez Oscar
Published: December 2019

Coffee pulp (C.P.) is a waste of coffee production that needs to be controlled. Due to its high moisture and sugar content, a diagnostic study that characterizes the pulp was conducted and the potential for hydrogen production was evaluated. Subsequently, the kinetics of hydrogen production in a bioreactor were evaluated. A biodegradability index of 0.91 (DBO5/DQO) was calculated, initial pH of the sample was 4.16 ± 0.05, a concentration of total volatile solids (TVS) of 58.1 ± 0.94 [g/L], and total sugar of 19.6 ± 0.79 [g Dextrose/L]. The yield was at 49.2 [NmL H2/g DQOInitial], the hydrogen production per fresh coffee pulp kilogram was 4.18 [L H2/kg C.P.], the energy density was determined at 0.045 [MJ/kg C.P.]. Modified Gompertz parameters were 585 [NmL] for Hmax, 4.1 [NmL H2/g DQO-h] for Rmax and a lag phase (λ) of 92.70 [h]. Because the yield of hydrogen production of coffee pulp estimated was similar to complex substrates like tequila vinasses, and there was a DQO reduction of 13.58%, based on some substrate restrictions, dark fermentation could be a stage of pretreatment of wastewater with coffee pulp in a biogas process to produce two relevant economic and energy products (hydrogen and biogas).
Atividade antifúngica in vitro dos óleos essenciais Eugenia uniflora e Psidium cattleianum contra o fitopatógeno Thielaviopsis basicola.
Authors: CASSINELLI Aline Barbosa , MACIEL Fábio Luís , FRONZA Juliana , SCHWANBACH Joséli
Published: December 2019

O fungo Thielaviopsis basicola (Berk. & Br.) Ferr é responsável por grandes perdas econômicas em diversas culturas agrícolas. O uso de óleos essenciais é uma técnica de controle alternativo de doenças fitopatogênicas. Este trabalho teve por objetivo caracterizar os compostos bioquímicos de óleos essenciais extraídos de folhas de Eugenia uniflora L (Pitanga) e Psidium cattleianum ‘Sabine (Araçá Vermelho) e avaliar se concentrações crescentes desses óleos essenciais aumentam a inibição do crescimento do fitopatógeno T. basicola. A caracterização dos compostos bioquímicos ocorreu pela análise em GC/MS em cromatógrafo gasoso. Para o teste in vitro foram utilizadas concentrações de 0,1%, 1,0% e 1,5% de cada óleo essencial extraído, sendo este diluído em meio BDA mantendo-se um tratamento controle (ausência dos óleos essenciais). Utilizou-se delineamento inteiramente casualizado, com cinco repetições. As placas foram incubadas por 19 dias à 25°C. As avaliações foram realizadas através de medições dos diâmetros das colônias. Verificou-se inibição de crescimento do fungo nas concentrações de 1,0% e 1,5% para ambos os óleos testados. Os resultados obtidos neste estudo demonstram que shiobunona e espatulenol são os compostos bioquímicos com maiores concetrações em óleo essencial de folhas de E. uniflora, enquanto 1.8-cineol é o composto bioquímico com maior concetração em óleo essencial de folhas de P. cattleianum. Ainda, os resultados obtidos confirmam a eficácia dos óleos essenciais no controle do crescimento de T. basicola, onde concentrações crescente desses óleos essenciais aumentam a inibição do crescimento desse fungo.
Culturas Populares, Educação e Descolonização
Authors: Rodolpho Jungers Abib Pedro
Published: December 2019

Este artigo pretende dar continuidade às discussões que venho fazendo a partir de publicações anteriores sobre culturas populares na contemporaneidade. Busco aqui, por um lado, ampliar as relações entre culturas populares e processos de educação, e por outro, estabelecer nexos entre culturas populares e a formulação de uma ação política decolonial que vem ganhando destaque nos últimos anos na América Latina. Compreendendo os sujeitos protagonistas das culturas populares enquanto importantes agentes políticos da descolonização em diálogo com a educação, trago o exemplo da capoeira enquanto prática decolonial. O argumento que pretendo defender é que as culturas populares podem ser compreendidas também como práticas de descolonização, aqui descritas enquanto resistência, conscientização e educação libertadora para aqueles que buscam fortalecer esse projeto decolonial em construção.
Profile of managers in brazilian Community Universities
Authors: Susana Jung Hildegard , Fossatti Paulo , Marlon Monticelli Jefferson
Published: December 2019

Our study aims to describe the profile of the managers of Brazilian community universities. Such a topic is justified by the need and lack of managers with a profile consistent with the new institutional demands of the 21st century. Therefore, we carried out qualitative research with 67 managers of 14 universities. Our analysis of the results was based on three categories: a) teaching experience concurrent with the management; b) strategic leadership; c) skills. The results emphasize the complexity of the manager profile and the need for training policies aimed at developing multiple managerial skills. We also highlight the relevance of community universities to society, especially in the South of Brazil, due to its scope of teaching, research, and extension fields associated with the management, thus enables the dissemination of knowledge.
Thiazolidine-2, 4-Diones as Non-Hepatotoxic Tri-action Drug Candidates: Design, Synthesis, Characterization, Biological Evaluation and Docking Studies
Authors: Shukla Karuna S. , Pandey Shailendra , Chawla Pooja A.
Published: December 2019

Thiazolidine-2, 4-diones and their derivatives are a well-established chemical class of compounds
that express their pharmacological actions through insulin sensitization and enhanced glucose
utilization in peripheral tissues. In the current research different approaches have been employed to
synthesize thiazolidine-2, 4-dione derivatives and these synthesized compounds were chemically characterized
for the establishment of their chemical structures. A series of thiazolidine-2, 4-dione (TZD)
derivatives, Scheme 1 (3A-3V) 22 compounds, were synthesized and characterized by FT-IR, 1H NMR
and mass spectral analysis. The title compounds were screened for their in vitro and in vivo antidiabetic,
antioxidant, and cytotoxicity studies. In vivo antihyperglycemic effect was assessed by measuring
plasma glucose (PG) levels in alloxan-induced type II diabetic rat models. The synthesized TZD
derivatives were evaluated for hepatotoxicity and pancreatic tissue integrity. Antioxidant activity was
evaluated by the DPPH method and H2O2 method. Thiazolidinedione derivatives were subjected to
predict free energy of binding towards target PPARγ, using rosiglitazone as the reference compound
for molecular docking visualization through the FlexX docking program. Molecular docking studies
are also performed for understanding the binding of a ligand to a receptor. The compound 3V 4-(5-
(naphthalen-1-ylmethylene)-2, 4-dioxothiazolidin-3-yl) benzoic acid exhibited better blood glucoselowering
activity than that of the standard drug rosiglitazone. Compound 3T and 3U exhibited potent
antioxidant activity. Among the tested compounds for cytotoxicity using an MTT assay, compound 3H
5-(4-chlorobenzylidene)-2, 4-dioxothiazolidin-3-yl) benzoic acid exhibited better viability and cytotoxicity
activity. From selected anti-diabetic targets, the proposed derivatives exhibited better interaction
with PPARγ receptor, for example, while rosiglitazone showed a docking score of -19.891 kJ/mol,
compound 3V exhibited highest docking score of -31.6617 kJ/mol. Computational molecular docking
study demonstrated the selectivity and provided a binding model for the further refinement of this
chemotype. Therefore, this series of thiazolidine-2, 4-diones derivatives (3A-3V) have considerable
importance for development as a potential antihyperglycemic and hypolipidemic agents.
Synthesis, Toxicity Profile and Pharmacological Evaluation of Some New N,N-Diphenyl Amine Derivatives with Special Reference to Analgesic and Anti-inflammatory Activity
Authors: Kumar Arvind , Mishra Arun K.
Published: December 2019

The present work was aimed to synthesize eight new diphenylamine derivatives by the reactions of 2-chloro-N-(4-(diphenyl amino) thiazol-2-yl)acetamide with substituted phenols in the chloroform along with anhydrous potassium carbonate and potassium iodide. The structures of newly synthesized compounds were characterized by IR, NMR, Mass and elemental analysis techniques. Toxicity profile (acute and subacute oral toxicity) and biological activity (analgesic and anti-inflammatory activity) of the synthesized derivatives was performed. Findings of the present work suggested that the synthesized compounds may be one of the excellent potent compounds to treat pain and inflammation. Therefore compounds of this group especially AK-4 (N-(4-(diphenylamino)thiazol-2-yl)-2-(2- nitrophenoxy)acetamide) could be an excellent starting point to build up new lead compounds in the management of pain and inflammation.
Vascular Inflammation in Hypertension: Targeting Lipid Mediators Unbalance and Nitrosative Stress
Authors: Bruno Alexandre S. , Lopes Patricia das Dores , de Oliveira Karla C.M. , de Oliveira Anizia K. , de Assis Cau Stefany B.
Published: December 2019

:

Arterial hypertension is a worldwide public health threat. High Blood Pressure (BP) is commonly associated with endothelial dysfunction, nitric oxide synthases (NOS) unbalance and high peripheral vascular resistance. In addition to those, inflammation has also been designated as one of the major components of BP increase and organ damage in hypertension. This minireview discusses vascular inflammatory triggers of high BP and aims to fill the existing gaps of antiinflammatory therapy of hypertension. Among the reasons discussed, enhanced prostaglandins rather than resolvins lipid mediators, immune cell infiltration and oxidative/nitrosative stress are pivotal players of BP increase within the inflammatory hypothesis. To address these inflammatory targets, this review also proposes new concepts in hypertension treatment with non-steroidal antiinflammatory drugs (NSAIDs), nitric oxide-releasing NSAIDs (NO-NSAIDs) and specialized proresolving mediators (SPM). In this context, the failure of NSAIDs in hypertension treatment seems to be associated with the reduction of endogenous NO bioavailability, which is not necessarily an effect of all drug members of this pharmacological class. For this reason, NO-releasing NSAIDs seem to be safer and more specific therapy to treat vascular inflammation in hypertension than regular NSAIDs.
Comparison of the Effects of Sambucus ebulus Leaf and Fruit Extracts on Leishmania major In Vitro
Authors: Kadkhodamasoum Samira , Bineshian Farahnaz , KarimiPour Amir , Tavakoli Pooya , Foroutan Masoud , Ghaffarifar Fatemeh , Molaei Soheila
Published: December 2019

Background;:

Leishmaniasis is one of the major diseases caused by the intracellular
parasite of Leishmania. It has become one of the most dangerous health problems today. Our aim
of the present study is to compare the effects of Sambucus ebulus leaf and fruit extracts on
Leishmania major in vitro.

Methods:

In this study, we used MTT, promastigote and amastigote assay to evaluate the effect of
different concentrations of the extract on parasite and we compared their effects. The flow cytometry
technique was also used to detect the apoptotic effect of the extracts on promastigotes.

Results:

According to MTT experiment IC50concentration of leaf and fruit extracts on parasite
was 157 μg/ml and 265 μg/ml, respectively. After analysis by flow cytometry, leaf and fruit extracts
also showed the apoptosis effect. Leaf and fruit extract caused 40.2 and 2.67 percent apoptosis.

Conclusion:

Based on the above assessment, we determined that the S. ebulus leaf extract has a
more toxic effect on promastigotes and amstigotes than its fruit extract and maybe in the future
that be used as a drug candidate.
Insulin Autoimmune Syndrome After Exposure to Clopidogrel: A Case Report
Authors: Jiang Yihong , Wang Lihua , Shi Fanghong , Zhou Huan , Zheng Jun , Cai Jie , Yang Shuang , Ma Jing , Liu Wei
Published: December 2019

Background:

Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia that is
characterized by hyperinsulinemia, hypoglycemia, and a high autoantibody titer. About 50% of patients
with IAS have taken a medication containing sulfhydryl (-SH) groups. We present a case of IAS
that developed after taking clopidogrel, a drug with an active metabolite that contains an SH-group.

Case report:

IAS was suspected in a 63-year-old Chinese man because of high concentrations of insulin
and C-peptide during hypoglycemic episodes, and positivity for anti-insulin autoantibody (IAA).
During his first episode of hypoglycemia, no trigger medication was identified and prednisone therapy
was effective. However, imaging examination revealed a colonic carcinoma and the patient was discharged
to undergo surgery. He had no episodes of hypoglycemia for 10 weeks after discontinuation of
the prednisone, but then hypoglycemia recurred. A review of his medication revealed that he had taken
a 10-day course of clopidogrel just before the recurrence. Therefore, a specialized multidisciplinary
team consisting of endocrinologists, dieticians, and clinical pharmacists took charge of his management.
Prednisone therapy was restarted and tapered off over 16 weeks. The patient also consumed
small, frequent, low-carbohydrate meals and was instructed to avoid trigger medications. No further
episodes of hypoglycemia were detected. His insulin and C-peptide concentrations and his anti-IAA
index normalized during the follow-up period.

Conclusion:

SH-group-containing drugs might induce or exacerbate hypoglycemia in patients with a
history of IAS. Furthermore, patients with IAS can benefit from multidisciplinary team management.
We suggest herein an evaluation process for patients suspected of IAS.
Synthesis and Thermal Stability of Palladium Nanoparticles Supported on γ-Αl2O3
Authors: Kalishyn Yevhen Y. , Ordynskyi Vladislav V. , Ishchenko Mykola V. , Bychko Igor B. , Kaidanovych Zinaida V. , Trypolskyi Andrii I. , Strizhak Peter E.
Published: December 2019

Background:

Deposition of palladium nanoparticles from colloidal
solution on various supports produces palladium catalysts with a predetermined size
and concentration of the palladium nanoparticles, which allows to study the
nanoparticle size effects and support influence on palladium catalytic properties.

Objective:

The goal of the present work was the development of a preparation
method of systems supported on γ-Al2O3 palladium nanoparticles with a controlled
size and determination of their thermal stability in oxidizing and reducing
atmospheres.

Methods:

We demonstrated the preparation of Pd/γ-Al2O3 composite by
precipitation of the size-controlled palladium nanoparticles with a narrow size
distribution from colloidal solution. The composites were characterized by X-ray
diffraction (XRD), and transmission electron microscope (TEM) methods.

Result:

The size and size distribution of the nanoparticles supported on γ-Al2O3
were found to be increasing upon precipitation due to strong Pd/γ-Al2O3 interaction.
A significant enlargement of the supported nanoparticles occured at 300°C. The
aggregation of the nanoparticles was observed at temperatures above 500°C
resulting in an increase in their size.

Conclusion:

Our findings are not only applicable for the preparation of a model
Pd supported on the γ-Al2O3 catalyst but could be applicable to the designing of the
Pd-containing catalyst for important industrial high-temperature processes.
O registo da auto-imagem na contemporaneidade
Authors: Pacheco Maria Emília Vaz
Published: December 2019

Num tempo global em que os artistas há muito deixaram de se fixar apenas nas formas e nos media tradicionais, designadamente no âmbito da Pintura e da Escultura, com recurso aos mais diversos materiais e mecanismos, incluindo a deslocação de objectos de uso quotidiano para o espaço da comunicação artística – as feiras de arte, as bienais e as galerias têm preferência sobre o museu - priorizando a atracção de públicos, através de meios como a fotografia, o vídeo, as instalações ou a performance, a par de uma cultura do acontecimento afastada de preocupações de carácter identitário, onde impera a banalização de atitudes acríticas, e em que cada vez mais se sente a ausência de regras para definir uma obra de arte, importará reflectir sobre as ligações que podem ser estabelecidas entre a auto-imagem pintada e a auto-imagem apresentada na selfie.
Novas festas profanas em Espanha
Authors: Brisset Demetrio E.
Published: December 2019

A sociedade espanhola atravessou uma profunda transformação desde a morte do ditador Franco. Uma das suas manifestações mais relevantes relaciona-se com as festas populares. A rígida moral católica que dominava o espaço festivo, controlado pela censura implacável, deu lugar, com a democratização das instituições políticas, a comportamentos festivos profanos, nos quais a vertente lúdica é central. Este artigo pretende resumir a evolução dos rituais festivos nos últimos oitenta anos, destacando as tendências e influências atuais: secularização, coexistência de modelos formais, intervencionismo institucional, integração no quadro europeu, incorporação das mulheres como protagonistas, dinamismo das associações e exaltação de proezas militares. Neste último ponto, destaca-se a conversão do esquema de luta entre duas fações – que monopolizava as celebrações de Mouros e Cristãos, de raízes medievais e baseadas no triunfo da verdadeira religião – em comemorações cívico-históricas (invasões romana e napoleónica, especialmente) de claro conteúdo profano, e mesmo pagão, como é o caso de recentes e numerosas festas na Galiza.
De dagboeknotities van Josué De Decker (mei 1916)
Authors: Vanacker Dani , Van Clemen Sam
Published: December 2019

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Activisten op veroveringstocht in de administratie: Machtsverwerving in het Ministerie van Financiën tijdens de Eerste Wereldoorlog
Authors: Vandeweyer Luc
Published: December 2019

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Recensie van: Achter de spiegel: terugblik op de oorlogsjaren / André Leysen (1995)
Authors: De Wever Bruno
Published: December 2019

recensie
Recensie van: Gerard Romsée : Een ongewoon man. Een ongewoon leven / Evrard Raskin (1995)
Authors: Wils Lode
Published: December 2019

recensie
Recensie van: Belgique: la force de la désunion / Alain Dieckhoff (1996)
Authors: Van Hees Pieter
Published: December 2019

recensie
Taaldiscriminatie en taalstrijd: De Vlaamse tolbeambten en het ministerie van financiën, 1894-1914
Authors: Van Velthoven Harry
Published: December 2019

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Параметры полупроводниковых пленок ZnO, легированных 3d-примесями Mn, Fe
Authors: Мездрогина М.М. , Виноградов А.Я. , Кожанова Ю.В.
Published: December 2019

Abstract The effect of Fe and Mn impurities on the magnetic parameters of ZnO wide-gap semiconductor films produced by high-frequency sputtering with wide variations in the defect concentration is studied. The introduction of Mn and Fe magnetic impurities brings about the existence of a magnetically ordered state in the semiconductor matrix, with different positions of the axis of easy magnetization. In the case of doping with Mn, this axis lies perpendicularly to the film plane, and in the case of doping with Fe, this axis lies in the film plane.
Математическое моделирование процесса выращивания монокристалла CdTe методом Обреимова--Шубникова
Authors: Павлюк М.Д. , Суханова Е.А. , Зыкова М.П. , Волчков И.С. , Каневский В.М. , Субботин И.А. , Подурец К.М. , Павлюк Б.Ф. , Иванов Ю.М.
Published: December 2019

Modeling the growth of CdTe crystal modified method Obreimov Shubnikov-using the of self-seeding techniques from the start cooling temperature (1100 °C) until the output to the mode stationary growth was carried out in this paper for the first time. Figures are given of changes in the crystallization front during crystal growth, which are confirmed by experiment using synchrotron radiation.
Рост кристаллов при спонтанной кристаллизации в неинерциальных системах в условиях космической станции и в условиях Земли на примере синтеза и роста кристаллов CrSi-=SUB=-2-=/SUB=- из раствора-расплава Zn
Authors: Калашников Е.В. , Гурин В.Н. , Никаноров С.П. , Деркаченко Л.И. , Яговкина М.А.
Published: December 2019

Abstract The effect of the terrestrial gravitation field on crystal growth from a solution–melt during spontaneous crystallization is considered, taking into account that the space station (SS) and a laboratory at the Earth, in which the crystallization processes occur, are a noninertial system. It is shown that the specific feature that distinguishes the crystal growth in the terrestrial conditions is the pressure in the melt caused by the supporting force (the Newton third law). This pressure is absent at SS, and this fact leads to an increase in the unit cell of the melt that undergoes the first-order phase transition. As a result, the crystals grown at the SS have larger sizes than the same crystals grown in terrestrial conditions. They also exhibit an excess stress, the value of which is equal to the support pressure, which is absent at the SS. This situation is compared to the experimental data on growing CrSi_2 crystals from a solution–melt in Zn of the Cr–Si–Zn system.
Влияние уровней Ландау на ССТС спектров ЭПР преципитатов Fe-=SUP=-3+-=/SUP=- в дираковском 3D-полуметалле Cd-=SUB=-3-=/SUB=-As-=SUB=-2-=/SUB=-
Authors: Горюнов Ю.В. , Натепров А.Н.
Published: December 2019

The influence of d-metal impurities on the magnetic and transport properties of the 3D topological Cd3As2 semimetal is experimentally studied. It was found that when doping with iron, unlike Eu, there is no change in the sign of magneto resistance. There is an increase in the oscillations of the quantities (magnetic susceptibility, contact potential difference, and conductivity) associated with oscillations in the density of states at the Fermi level with temperature and magnetic field. In the temperature range of 10–300 K, EPR signals from Fe2+ ions were not detected, although, most likely, are the main type of Fe impurity in Cd3As2. From Fe3+ ions, weak EPR signals with a super-hyperfine structure (SHFS) were observed, which are obviously effected by Landau levels.
Парамагнитные антисайт Mn-дефекты в нанокерамике алюмомагниевой шпинели
Authors: Зацепин А.Ф. , Киряков А.Н. , Байтимиров Д.Р. , Дьячкова Т.В. , Тютюнник А.П. , Зайнулин Ю.Г.
Published: December 2019

The influence of structural and dimensional factors on the formation of intrinsic and impurity paramagnetic centers in nanoceramics of aluminum-magnesium spinel is studied. The studied samples (with a grain size of 30 nm) were obtained by thermobaric synthesis. Microcrystalline ceramics and a MgAl2O4 single crystal were used as standards. The single crystal and microceramics contain characteristic Mn2+ paramagnetic centers (hyperfine structure constant (HFS) A = 82 G). In the studied nanoceramic samples in the initial state, both impurity Mn2+ and intrinsic F+ centers are detected. In contrast to nanoceramics, in reference samples centers of the F+ type appear only after irradiation with 130 keV by accelerated electrons. The parameters of the Mn2+ centers in nanoceramics differ significantly from those in microceramics and single crystals. For the Mn2+ center in nanoceramics, the EPR signal is characterized by two anomalous HFS constants (A1 = 91.21 G, A2 = 87.83 G) caused by two varieties of octahedrally coordinated manganese ions (anti-site defects [Mn2+]Al3+). The specific features of the spectral parameters of manganese centers correlate with a decrease in the lattice parameter of MgAl2O4 in the nanostructured state. The observed effects are interpreted based on the proposed charge compensation scheme of [Mn2+]Al3+ with an aluminum anti-site defect and an F+ center.
Электропроводность структур металл--диэлектрик--полупродник на основе сегнетоэлектрических пленок
Authors: Афанасьев М.С. , Гольдман Е.И. , Чучева Г.В. , Набиев А.Э. , Гусейнов Дж.И. , Алиев Н.Ш.
Published: December 2019

Abstract In this paper, we present the results of experimental studies of the frequency and temperature dependences of the electrical conductivity of metal–dielectric–semiconductor structures based on ferroelectric films of the Ba_0.8Sr_0.2TiO_3 composition. In the temperature range of 290–400 K and the frequency range of 25–10^6 Hz, the conductivity was found to obey the σ ∝ f  ^0.76 law, which is characteristic of the hopping mechanism of charge transfer over states localized near the Fermi level. The density of these states, average distance and time of jumps are estimated.
Моделирование одноосной деформации нанокристаллов магния "жесткой " и "мягкой" ориентировок
Authors: Власова А.М.
Published: December 2019

Abstract. Atomistic modeling of high-speed deformation by compression of ideal, defective (5% vacancies, 5% impurity hydrogen atoms) magnesium nanocrystals with "hard" and "soft" orientations at T = 300 – 375 K was carried out. Three interatomic interaction potentials were used. The evolution of the microrelief of the free surface of magnesium nanocrystals in the process of plastic flow is shown. Diagrams "stress σ – deformation ε" are constructed, deformation dependences of the scalar dislocation density are determined, and the strain rate dependences on the degree of deformation ε are constructed. The influence of vacancies and hydrogen atoms on the shape of deformation curves, dislocation structure and scalar dislocation density is shown. Evolution of typical dislocation structures is shown, some typical dislocation reactions are given. Conclusions are drawn on the influence of the type of interatomic interaction potential on the calculated characteristics.