bluuebunny/crossref_metadata_2025 huggingface dataset:
Foeto-foetal transfusion syndrome in dichorionic diamniotic twins: a clinical case
Authors: Gordeeva E. K. , Pomortsev A. V. , Vasina I. B. , Asriants M. A. , Sadovnikova T. A.
Published: April 2021

Background. Management of multiple gestation complicated by the foeto-foetal transfusion syndrome is among most intricate modern obstetric issues. The syndrome develops in 10–20% of monochorionic diamniotic twins leading to 80–100% mortality in one or both twins if left uncorrected, especially in early syndrome cases. Although foeto-foetal transfusion usually develops with monochorionic placentae, there are notable exceptions of vascular placental anastomoses reported with dichorionic monozygotic twins. The disease supposedly entails from an imbalanced blood interflow between dichorionic twins due to placental vascular anastomoses.

Clinical Case Description. Patient S., 32 yo, visited perinatal diagnostics at the Territorial Perinatal Centre of the Children’s Territorial Clinical Hospital with a preliminary diagnosis: 22 weeks and 5 days’ pregnancy. Dichorionic diamniotic twins. Threat of extremely preterm birth. Two caesarean uterine scars. Gestational diabetes mellitus.

Medical files: patient history, pregnancy calendar. Pregnancy was regularly monitored with main ultrasound foetometry, foeto-foetal transfusion dynamics control and Doppler velocimetry.

Ultrasonographic signs of abnormal haemodynamics underlying the foeto-foetal transfusion syndrome were detected at the first scan at 11–13 weeks 6 days’ term as collar space thickening in one foetus. Hydramnios in one foetus and oligohydramnios in the other were diagnosed at 28 weeks’ gestation conclusively indicating the foeto-foetal transfusion syndrome. This evidence suggested the formation of placental anastomoses, which was confirmed morphologically in placenta examination.

Conclusion. A timely diagnosis and correction of emerging complications allowed prolongation of pregnancy in hospital conditions to 33–34 weeks. Both boys were live-born with Apgar score 7–8.
Interleukin-18 gene polymorphism in pregnancy With premature rupture of membranes: A case-control study
Authors: Bushtyreva I. O. , Kuznetsova N. B. , Dmitrieva M. P. , Mashkina E. V. , Oksenyuk O. S. , Barinova V. V.
Published: April 2021

Background. Imbalanced pro- and anti-inflammatory systems can unfavourably condition carrying of pregnancy and provoke gestation complications, such as premature rupture of membranes.

Objectives. Assessing the contribution of SNP variants -137G>C (rs187238), -607G>T (rs1946518) and -656A>C (rs5744228) of the IL-18 gene promoter to the incidence of extremely preterm premature rupture of membranes.

Methods. A case-control study enrolled 120 pregnant women managed at the Perinatal Centre. The women were divided in two cohorts. The study cohort comprised 80 women with premature rupture of membranes at 22–27 weeks 6 days’ gestation hospitalised in a high-risk pregnancy unit, a control cohort consisted of 40 women with physiological pregnancy at 22–27 weeks 6 days’ gestation following outpatient counselling. The cohorts had comparable obstetric and gynaecological histories. The study exclusion criteria were: multiple gestation, foetal chromosomal anomalies, congenital foetal malformations, pregnancy due to assisted reproduction. Genotyping was performed at positions -137G>C, -607G>T and -656A>C of the IL-18 gene promoter with determining a peripheral blood IL-18 level in cohorts.

Results. The premature rupture of membranes cohort had a statistically higher serum interleukin-18 concentration compared to control (p = 0.001). Genotyping of the IL-18 gene promoter revealed a statistically higher rate of homozygous -137G>C mutation (CC genotype) in the premature rupture of membranes cohort at 22–27 weeks 6 days’ term (p <0.001), 67 vs. 27% in control.

Conclusion. A homozygous IL-18 -137G>C polymorphic variant associated with elevated blood IL-18 levels is statistically more common in pregnant women having premature rupture of membranes at 22–27 weeks 6 days’ gestation.
Ragweed pollen rain impact on allergy rate and severity in Krasnodar: a three-year non-randomised controlled study
Authors: Klimenko Ya. V. , Milchenko N. O. , Moroz A. N. , Pavlyuchenko I. I. , Alekseenko E. A.
Published: April 2021

Background. The main hay fever agent in Krasnodar Krai is ragweed pollen (Ambrosia gen.). An important alerting guide for medical practitioners and allergic citizens is the seasonal anthetic calendar and pollen peak times.

Objectives. Obtaining of relevant data on ragweed pollen air contamination rate in Krasnodar in a three-year-dynamics (2018–2020) to estimate the anthetic activity correlation with abiotic and anthropogenic factors and the role of pollen indicators in allergic morbidity.

Methods. We surveyed the daily average ragweed pollen values in Krasnodar air. Allergic medical visits were analysed in terms of the ragweed anthetic activity and pollen air contamination of the city.

Results. A maximal daily average ragweed pollen peak occurs in August: 663.35 p.g./m3 in 2018, 209.89 p.g./m3 in 2019, 80.62 p.g./m3 in 2020. Numbers of medical visits for pollinosis per a selected municipal medical facility: 314 in 2018, 335 in 2019 and 146 in 2020, with a peak period in September--October. Analyses of the air pollution impact on ragweed pollen production revealed a correlation between the pollen rate and values of CO (correlation coefficient r-0.356), NH3 (r-0.198) and dust pollution (r-0.361) in July, August, September and October 2018–2020.

Conclusion. Analyses of climatic factors uncovered clear patterns: strongest anthesis corresponds to minimal humidity (<60%), the pollen grain content diminishes with lower humidities dropping to minimal with precipitations and increases at temperatures 20 °C and above. No significant dependency was observed between air pollution and the allergic pollen content. Anthesis in ragweed moderately correlates with the rate of medical visits.
Osteosarcoma of the temporal bone occurring 40 years after radiotherapy: A technical case report presenting en bloc resection of intra- and extracranial lesions followed by a one-stage reconstruction
Authors: Funakoshi Yusuke , Shono Tadahisa , Kurogi Ai , Kono Shinji
Published: April 2021

Background:

Osteosarcoma (OS) is a malignant tumor of the bone, which rarely occurs in the head-and-neck regions as a primary or a secondary malignancy. Adequate surgical resection is currently the mainstay of treatment for head-and-neck OS; however, en bloc resection and reconstruction can be difficult because the anatomies of these regions are complex. We present a case of an OS arising from the temporal bone 40 years after radiation therapy, which was successfully treated with en bloc resection and a one-stage reconstruction using intraoperative tissue expansion technique.

Case Description:

A 62-year-old woman who underwent surgery and radiotherapy for a left temporal lesion 40 years before presentation was hospitalized for aphasia and a right hemiparesis. She had a 4 × 3 cm subcutaneous mass in the left temporal area of the head. Computed tomography imaging showed destruction of the left temporal bone and a partially calcified mass. Magnetic resonance imaging showed an enhancing mass with intracranial and extracranial cystic components (5 cm and 3 cm in diameter, respectively). Due to rapid growth of the lesion, a semi-urgent surgery was performed. In this operation, a continuous narrow craniectomy was performed around the tumor using a ruler. Then, en bloc resection of the tumor, with adjacent skin, temporal muscle, skull, dura mater, and cerebral cortex, was achieved. Subsequently, a one-stage reconstruction of the dura mater, skull, and skin of the head was performed using fascia lata, artificial bone, and a local skin flap combined with intraoperative tissue expansion using a 20-French Foley catheter. Postoperative histological examinations revealed the tumor to be an OS.

Conclusion:

We have presented a rare case of an OS occurring from the temporal bone 40 years after radiation therapy. We describe our experience and the surgical methods in this case to provide options for surgical strategies in patients with head-and-neck OS.
Optical coherence tomography: problems and solutions
Authors:   Fyodorov Eye Microsurgery Federal State Institution, Moscow, Shpak A.A.
Published: April 2021

В книге рассмотрены основные проблемы, возникающие при оценке количественных результатов измерений, выполняемых методом оптической когерентной томографии. Освещены вопросы точности, повторяемости и воспроизводимости измерений. Изложены принципы сопоставления с нормативными базами данных и дан сравнительный анализ нормативных баз на приборах для оптической когерентной томографии разных производителей. Выработаны рекомендации по оценке измерений оптической когерентной томографии у детей и подростков и у пациентов с аномалиями рефракции. Изучена роль артефактов оптической когерентной томографии и предложена их рабочая классификация. Книга предназначена для врачей-офтальмологов, специалистов в области оптической когерентной томографии
Screening and prevention of vascular retinal pathology in women with preeclampsia
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Kolenko O.V. , Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Fil A.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation
Published: April 2021

В методическом пособии изложены рекомендации по осуществлению скрининга и профилактики сосудистой ретинальной патологии у женщин с преэклампсией. Пособие предназначено для врачей-офтальмологов и клинических ординаторов по специальности «Офтальмология»
Clinical and functional characteristics of arterial stiffness in elderly
Authors: Murkamilov Ilkhom T. , Aitbaev Kubanych A. , Fomin Viktor V. , Murkamilova Zhamila A. , Redzhapova Nodira A. , Yusupov Furkat A.
Published: April 2021

Aim. Purpose of the study. To study the clinical and functional features of the parameters of arterial stiffness in the elderly, depending on gender differences.

Materials and methods. The study included 497 therapeutic patients aged from 60 to 74 years. The average age of the examined patients was 65.13.9 years. All patients underwent a comprehensive clinical and instrumental examination. The study of the parameters of arterial stiffness and central arterial pressure (BP) was carried out on the AngioScan-01 apparatus (AngioScan-Electronics, Russia). Depending on the sex differences, the entire sample was divided into two age-matched groups: women (n=287) and men (n=210).

Results. In the group of women, systolic levels (13820 mm Hg vs 13419 mm Hg; p=0.018), central (13720 mm Hg vs 13319 mm Hg; p=0.024), average (469 mm Hg vs 456 mm Hg; p=0.018), pulse BP (5316 mm Hg vs 5014 mm Hg; p=0.038), the value of the double product (107.423.5 conventional units vs 101.422.5 conventional units; p=0.004), augmentation index (AI) [22.1 (13.5, 31,3)% vs 15.9 (8.8; 24.9)%; p=0.005], the increase index at a pulse frequency of 75 per minute [23.2 (16.0; 30.5)% vs 15.9 (9.2; 23.5)%; p=0.005] and systole duration in percent (35.505.60 vs 34.244.53; p=0.007) were significantly higher than in the group of men. In addition, men showed a statistically significant increase in the average value of the alternative stiffness index (9.762.61 vs 8.172.03; p=0.005) and the dependence of the AI on age (p0.05). At the same time, a statistically more significant correlation of central and peripheral hemodynamic parameters with the presence of elevated AI (p0.05) was recorded in the group of women.

Conclusion. In older women, an increase in systolic, central, average, pulse BP is associated with an increase in AI and an increase in the magnitude of the double product. In the group of elderly men, the increase in the alternative vascular stiffness index contributes to an increase in the duration of the pulse wave. Statistically more pronounced correlation relationships between the value of the AI and clinical and hemodynamic parameters were recorded in elderly women.
The Core Elements of Motivational Factors that Influence Facebook Users to Self-Disclosure
Authors:   University of Malaya, Malaysia, Ajis Adnan
Published: April 2021

This study examines the motivational factors that influence Facebook users among the Malaysian Army to self-disclosure by adapting the Uses and Gratification Theory. All data were obtained from 1513 Facebook users in various military units in Peninsular of Malaysia, Sabah and Sarawak. Its dimension of breadth and depth measures the self-disclosure. The study found that information sharing, social interaction and self-expression are positively associated with breadth of self-disclosure and; relaxing entertainment and self-expression are positively related to the depth of self-disclosure. Meanwhile, social interaction is negatively associated with depth of self-disclosure. However, information sharing is not related to depth of self-disclosure and relaxing entertainment is not related to breadth of self-disclosure.
A Bibliometric Analysis on Ethical Climate
Authors:   University of Malaya, Malaysia
Published: April 2021

The purpose of this study is to retrieve and explore past studies done on ethical climate. A search using the bibliometric analysis method was made on the Web of Science (WoS) database for publications of between 1970 until 2020. The VOS Viewer software was used to retrieve and explore numerous aspects of these publications, such as author keywords, bibliographic coupling of the publications, journals, countries, and authors. Analysis indicated that the most prominent publication was, “Bad Apples, Bad Cases and Bad Barrels: Meta-Analytic evidence about sources of unethical decision at work” authored by Kish-Gephant, Harrison and Trevino (2010). It was also noted that the journal with the most impact was the Journal of Business Ethics followed by the journal of Nursing Ethics. The prominent countries engaged in ethical climate publications were: the USA, China and Turkey, in that order. Analysis also showed that the most prominent authors/researchers were Borhani and Fariba, with eight articles. In examining the concepts that were associated with ethnical climate, it was identified that ethical leadership, moral distress, organizational climate and employee burnout were the most frequently studied.
Mobile Technology and Organizational Culture: The Challenges of Using Mobile Instant Messaging for Managing Work in the Malaysian Army
Authors:   University of Malaya, Malaysia
Published: April 2021

Mobile technology is one of the most favoured communication platforms in modern organizations. However, the organizations facing challenges in utilizing this technology and have given little regard to the possible setbacks of its usage. In the Army, the use of mobile instant messaging (MIM) may create conflicts with its command function, the flow of information, work focus, and military doctrines and values. The paper explains the nature of organizational communication in the Malaysian Army and the challenges of MIM usage in the Army working environment in the context of organizational culture. The findings based on the case study on the suitability of MIM usage in the Malaysian Army. Twelve Army officers from the ranks of Major and Lieutenant Colonel were selected for semi-structured interviews. The study discovers that military organization is a unique entity that having its own norms of work and social relationship and the values of the Army should be preserved during communication. The paper ends with recommendations to commanders and managers in the Army on how the technology should be utilized at the workplace.
Kesan Harga dan Kualiti Makanan Terhadap Tahap Kepuasan Pengguna Trak Makanan (Food Truck)
Authors:   Politeknik Sultan Abdul Halim Muadzam Shah, Jitra, Mohtar Azzamurni
Published: April 2021

Perniagaan dengan menggunakan trak makanan (food truck) semakin popular dan menjadi satu trend perniagaan di Malaysia. Perniagaan trak makanan merupakan satu cabang perniagaan bagi usahawan perusahaan kecil dan sederhana (PKS). Kajian ini telah dilaksanakan untuk mengenalpasti kesan factor harga dan kualiti makanan terhadap tahap kepuasan pengguna untuk trak makanan (food truck). Kedah kutipan data yang digunakan untuk kajian ini adalah dengan menggunakan boranf soal selidik daripada 100 orang pengguna trak makanan di Kedah. Data kajian yang diperolehi telah dianalisis menggunakan perisian IBM SPSS versi 22. Hasil kajian mendapati factor harga dan kualiti makanan mempengaruhi tahap kepuasan penguna terhadap Trak Makanan.
Application of Technology Acceptance Model (TAM) in predicting user intention to use Malaysian Business Reporting System (MBRS): A Conceptual Paper
Authors:   Politeknik Sultan Abdul Halim Muadzam Shah, Uyob Roslee
Published: April 2021

On 27 September 2018, SSM has introduce a new submission platform known as Malaysian Business Reporting System (MBRS) that allow company in Malaysia to submit annual submission filing in Extensible Business Reporting Language (XBRL) format. Currently, submission filing using MBRS platform is only mandatory for unaudited companies’ and Certificate for Exempt Private Company (EPC) but it is expected that the mandatory submission shall be enforced to other type of companies soon. By applying Theory Acceptance Model (TAM), this study proposes a conceptual model to examine the behavioral intention to use MBRS by accounting practitioners in Malaysia. The resulting model will guide the development of strategies, especially for the Companies Commission of Malaysia (SSM) in promoting MBRS adoption in the future reporting.
Factors Influencing Purchasing Intention of Smartphone Brand: A Study on Female Students in University Malaysia Perlis (UNIMAP)
Authors:   Universiti Malaysia Perlis, Malaysia, Ahmad Nurizzah
Published: April 2021

The purpose of this paper is to investigate the factors that influence the purchase intention of smartphone among female university students in University Malaysia Perlis. Mobile communication has made an impact towards interaction between people while conducting business either locally or internationally. The expansion of mobile communication technology such as wireless internet, mobile phone and Global Positioning System (GPS) are constantly evolving and upgrading and it will affect the result of consumers’ changing needs and preferences. As a result, this research has carried out to identify the factors influencing purchasing intention of smartphone among female students in University Malaysia Perlis (UniMAP). This study investigates the relationship between brand image, price, product features, peer group and purchase intention towards smartphone brands. This survey was conducted by distributing questionnaires and the data was run using SPSS. The result shows that there is a positive and significant relationship among all the independent variables and all hypothesis is accepted. Based on these results, it seems that the smartphone company needs to enhance their product with affordable price and develop marketing strategy to attract consumer especially female consumers as they play an important role in purchasing power and increase purchase intention.
The Impact of E-Marketing on Business Performance in Northern Malaysia
Authors:   Universiti Malaysia Perlis, Malaysia, Abdul Jamil Anis Hanani
Published: April 2021

This research is to investigate the impact of e-marketing on business performance in Northern Malaysia. This research will investigate the impact of e-marketing on business performance towards e-marketing orientation, perceived relative advantage, customer pressure and level of competition. The target respondent for this research are SMEs companies and entrepreneur with companies. Furthermore, the questionnaires were distributed through online by using simple random sampling technique. In result, 30 set of questionnaires were collected to see whether all the impact of e-marketing on business performance. This research will be analysed by using Statistical Package for Social Science (SPSS) version 25. SPSS will be using to conduct descriptive analysis, frequency analysis, correlation analysis, reliability test and multiple regression analysis. Additionally, this research shows the result which independent variable that consists e-marketing orientation, perceived relative advantage, customer pressure and level of competition has no positive relationship between strategic business performance. Meanwhile, independent variable for convenience shows that there is a positive relationship towards dependent variable. Moreover, this research shows the clearer overview regarding the impact of e-marketing towards strategic business performance. Lastly, the limitation on doing this research were identified and implication for further research were recommended.
The Impact of Purchasing Behaviour towards Digital Marketing in Kangar, Perlis
Authors:   Universiti Malaysia Perlis, Malaysia
Published: April 2021

Marketing activity through digital medium is becoming popular among the entrepreneurship. This have managed to influence the purchasing behavior of the citizens. However, there certain people who still doubting the use of technology in daily life. There also a few people whom still not confident in using technology. Thus, this purpose of this study is to research the impact of purchasing behavior toward digital marketing. Theory of planned behavior is use in this research to explain the independent variables, which is attitude, subjective norms, perceived behavior and pricing that effecting the purchasing behavior. Besides, descriptive analysis, correlation analysis and regression analysis are use analyze the significant of independent variables towards dependent variable. This study uses quantitative method and 381 sets of questionnaires are distributed around Kangar. Reliability test are conduct for 40 respondents and obtain Cronbach’s Alpha 0.731, which is acceptable. Statistical Package for the Social Sciences (SPSS) is used to evaluate the data collected. Under regression analysis, this study find out that the attitude, subjective norms and pricing have an impact to digital marketing. While perceived behavior control has no significant to the dependent variable.
​Employees’ Feedback: Critical Success Factors in Managing Compliance Efficiency in an Organisation
Authors:   International Islamic University, Malaysia, Rahmat Nadya Naina
Published: April 2021

There is clear a need to measure and analyse data that will guide an organization to manage compliance in the most effective manner. Despite its importance, a valid and reliable instrument, particularly one that manages employees’ feedback, is hardly available. One primary aim of this study was to examine the extent to which a 4-dimension self-reported compliance, as perceived by the employees, constituted an adequate measure in terms of its reliability, convergent validity and discriminant validity. Another aim of the study was to test the measurement equivalence of the tool for male and female employees. The sample consisted of 250 employees from several private companies in Malaysia. The data was analysed using a confirmatory factor analysis on the sample’ responses to 12 perception items. The study supported and extended the results of previous work on employees’ feedback and perceptions towards policy and procedure compliance. The study found evidence that the instrument measures a valid and reliable multidimensional construct, and it is gender-invariant using Confirmatory Factor Analysis (CFA). Thus, the instrument is a useful tool for business leaders to facilitate their efforts in ensuring that day-to-day operations meet their business objectives as well as the necessary regulatory requirements.
Unit-Lapse Forms of Various Spacetimes
Authors:   , Baines Joshua
Published: April 2021

Every spacetime is defined by its metric, the mathematical object which further defines the spacetime curvature. From the relativity principle, we have the freedom to choose which coordinate system to write our metric in. Some coordinate systems, however, are better than others. In this text, we begin with a brief introduction into general relativity, Einstein's masterpiece theory of gravity. We then discuss some physically interesting spacetimes and the coordinate systems that the metrics of these spacetimes can be expressed in. More specifically, we discuss the existence of the rather useful unit-lapse forms of these spacetimes. Using the metric written in this form then allows us to conduct further analysis of these spacetimes, which we discuss.

Overall, the work given in this text has many interesting mathematical and physical applications. Firstly, unit-lapse spacetimes are quite common and occur rather naturally for many specific analogue spacetimes. In an astrophysical context, unit-lapse forms of stationary spacetimes are rather useful since they allow for very simple and immediate calculation of a large class of timelike geodesics, the rain geodesics. Physically these geodesics represent zero angular momentum observers (ZAMOs), with zero initial velocity that are dropped from spatial infinity and are a rather tractable probe of the physics occurring in the spacetime. Mathematically, improved coordinate systems of the Kerr spacetime are rather important since they give a better understanding of the rather complicated and challenging Kerr spacetime. These improved coordinate systems, for example, can be applied to the attempts at finding a "Gordon form" of the Kerr spacetime and can also be applied to attempts at upgrading the "Newman-Janis trick" from an ansatz to a full algorithm. Also, these new forms of the Kerr metric allows for a greater observational ability to differentiate exact Kerr black holes from "black hole mimickers".
Fibromyalgia as A Sole First Presentation of Recurring Idiopathic Intracranial Hypertension in a child. A Case Report and Literature Review
Authors:   1Pediatric Neurology Division, Sidra Medicine, Doha, Qatar 2Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar 3Department of Pediatrics, Sidra Medicine, Doha, Qatar 4Ophthalmology Division, Department of Surgery, Sidra Medicine, Doha, Qatar 5Weill Cornell Medicine – Qatar
Published: April 2021

Idiopathic intracranial hypertension (IIH) is a condition characterized by raised intracranial pressure (ICP) with no evidence of brain pathology, also known as pseudo tumor cerebri. Headache and visual obscuration are the most common presenting symptoms for IIH with a frequency of (68-84%) respectively. Other symptoms of IIH include neck pain, back pain, and radicular pain in the arms and legs resulting from increased spinal pressure and forced filling of the spinal nerves with CSF. Case summary: We present an 11-year-old boy known to have chronic kidney disease stage II, due to obstructive uropathy. He had a history of Idiopathic intracranial hypertension that was treated completely and condition resolved, then presented with generalized pains and aches without headaches or visual symptoms and found to have IIH for the second time, the symptoms resolved with appropriate treatment. Conclusion: Widespread pain and several other characteristics of IIH share similarities with characteristics of fibromyalgia (FM) and chronic fatigue syndrome (CFS), two overlapping chronic pain conditions.
Tuta absoluta (Meyrick, 1917) (Lepidoptera: Gelechiidae)’nın Yumurta Bırakma Davranışına Farklı Uçucu Yağların Etkisi
Authors: BİRGÜCÜ Ali Kemal , BAYINDIR EROL Alime , ÇELİKPENÇE Yakup
Published: April 2021

Domates (Solanum lycopersicum L.) üretim potansiyeli çok yüksek olan en önemli sebzelerden biridir. Bununla birlikte içerdiği çeşitli vitaminler, organik maddeler ve mineraller ile insan sağlığı ve beslenmesi açısından oldukça önemlidir. Üretimi sırasında üretimi doğrudan veya dolaylı olarak etkileyebilecek önemli zararlılar kaydedilmiştir. Bu zararlılar içerisinden domates yaprak galeri güvesi Tuta absoluta (Meyrick, 1917) (Lepidoptera: Gelechiidae) günümüzde domatesin ana zararlısı olarak belirlenmiştir. Bu çalışmada biberiye, yayla kekiği, okaliptüs ve zencefil uçucu yağlarının T. absoluta’nın yumurta bırakma davranışı üzerindeki etkisi araştırılmıştır. Yapılan çalışma sonucunda uçucu yağların zararlıya karşı uzaklaştırıcı etki indeksleri sırasıyla 22.11, 52.54, 21.61, 59.09 olarak kaydedilmiştir. Uçucu yağlardan biberiye, yayla kekiği, okaliptüs ve zencefil yağlarının uygulandığı domates bitkilerinde, kontrol bitkilerine oranla daha az yumurtanın bırakıldığı görülmüştür. Bu çalışma sonucunda biberiye, yayla kekiği, okaliptüs ve zencefil uçucu yağların T. absoluta’nın ergin bireyleri üzerinde uzaklaştırıcı etkisinin olması sebebiyle alternatif mücadele yöntemleri içerisinde kullanılabileceği öngörülmektedir.
REDEFINIENDO EL CONCEPTO DEL REMANENTE URBANO: UNA MIRADA EN LA CIUDAD DE MEXICALI, BAJA CALIFORNIA.
Authors: Curzio Claudio , Moreno Codina Tonahtiuc
Published: April 2021

Hablar sobre los remanentes urbanos nos lleva a reflexionar acerca de diversos espacios perdidos que cotidianamente observamos en el paisaje urbano de una ciudad, básicamente este fenómeno tiene que ver con aquellos derechos de vías que van quedando olvidados al costado de avenidas, vías férreas, ríos ó incluso canales, también hablamos de aquellos espacios bajo puentes o distribuidores viales, así como de camellones o guarniciones inconclusas; en general son aquellos fragmentos de ciudad que gradualmente van resultando como sobrantes de un proyecto de gran escala así como de una producción urbana desordenada y especialmente descuidada en cuanto a brindar atención (preventivamente desde la ejecución del proyecto urbano) ó solución (correctivamente desde los planes de desarrollo municipales). En la actualidad los remanentes urbanos se presentan como una forma de anti-espacio urbano y puntualmente deben ser comprendidos como una tipología especifica que pertenece al ámbito de los espacios residuales, y en ese sentido el presente trabajo de investigación se pretendió llevar más allá de un conjunto de reflexiones teóricas debido a que también se expone un ejercicio práctico, el cual estuvo enfocado en realizar un levantamiento de casos de estudio en la ciudad de Mexicali y donde fue posible detectar un total de 123 casos prácticos que fueron identificados dentro del área urbana consolidada de esta ciudad.
Arquitectura contemporánea en centros históricos: Una mirada desde la ciudad de Tunja.
Authors: Camargo Castillo Sebastian Alonso , Muñoz Cárdenas Felipe Andrés
Published: April 2021

Realizar estudios sobre centros históricos implica hacerse cargo de retos teóricos, históricos y prácticos que dependen de la ciudad objeto de estudio. Acotar correctamente el concepto de centro histórico, entender las dinámicas que lo han transformado con el tiempo y la dificultad para acceder a la información existente, hacen de este tipo de estudios una entrada a nuevas metodologías de análisis y recolección de información para entender las ciudades contemporáneas y sus centros históricos. Tunja tiene un centro histórico valioso, posee importantes edificaciones de los siglos XVI y XVII en muy buen estado, testigos de las transformaciones que ha tenido la arquitectura y el urbanismo durante los últimos quinientos años.  Sin embargo, la información que se encuentra es fragmentada y desactualizada. Este artículo presenta la metodología usada para recolectar y organizar datos del centro histórico de Tunja, haciendo énfasis en información urbana y arquitectónica para inventariar lo existente al tiempo que se rastrean las transformaciones sufridas a lo largo del tiempo. También se busca determinar la forma en que la normativa actual influye en estas transformaciones, y cómo la arquitectura contemporánea se adapta para insertarse dentro del tejido histórico, afectando su contexto, pero sin detener las dinámicas propias del centro.
Bases de la modernidad de la arquitectura de quito del Siglo XX
Authors: Camacho Aguirre Erick Santiago , Medina Ortega Marco Antonio
Published: April 2021

Los textos de arquitectura que estudian la modernidad en la ciudad de Quito son en su mayoría una recopilación de edificios o de autores y descripciones de sus obras, por lo que no aportan al entendimiento de cómo se representó la modernidad en la ciudad. En consecuencia, se carece de un trabajo que analice los hechos que influyeron en cómo las manifestaciones y expresiones de la modernidad se concretaron tanto en la sociedad como en la arquitectura de la ciudad. Este artículo hace una revisión cronológica, entrelazando los hechos históricos del Ecuador desde lo político, lo económico y lo social, para explicar las razones de cómo se cimentaron las bases de la modernidad en la ciudad de Quito. La explicación se hace dentro de un marco de entendimiento desde las visiones de autores como Bolívar Echeverría y David Harvey, proponiendo un análisis de las particularidades históricas del país y de la ciudad. Para ello se analiza el crecimiento de la ciudad, identificando expresiones arquitectónicas representativas y evidenciando los momentos en que las bases de la modernidad se presentaron y gestaron particularidades que se manifestaron en la ciudad de Quito en respuesta a su propio modelo social, económico y político local.
Development of a Companion Diagnostic PD-L1 Immunohistochemistry Assay for Pembrolizumab Therapy in Head and Neck Squamous Cell Carcinoma
Authors: La Placa Christopher J. , Vilardo Monika. , Watts Brittany , Polewski Monika , Tabuena-Frolli Siena , Jansson Malinka , Emancipator Kenneth , Jin Fan , Gumuscu Burak , Ge Joy Y. , DiMaio Michael , Kulangara Karina
Published: April 2021

Objectives: FDA approval of PD-L1 IHC 22C3 pharmDx for use as an aid in identifying head and neck squamous cell carcinoma (HNSCC) patients for treatment with pembrolizumab was based on the results of rigorous analytical and clinical validation testing. Methods: For the HNSCC indication, the device was validated at Agilent Technologies on the performance of sensitivity and precision using the Combined Positive Score (CPS) ≥ 1 and CPS ≥ 20 cutoffs; external validation studies were performed at three external laboratories. CPS ≥ 1 and CPS ≥ 20 cutoffs were evaluated in KEYNOTE-048, a phase 3 clinical trial. Results: Analytical validation studies supporting the companion diagnostic indication (CPS ≥ 1) achieved point estimates of > 85% for negative, positive, and overall percent agreement. Clinical validation studies show that HNSCC patients treated with pembrolizumab as a single agent had an overall survival (OS) of 12.3 months at CPS ≥ 1 (95% CI, 10.8-14.9) compared with patients receiving cetuximab, platinum, and 5-fluorouracil (CPS ≥ 1 OS of 10.3 months (95% CI, 9.0-11.5)). Conclusion: Analytical and clinical validation studies demonstrate that PD-L1 IHC 22C3 pharmDx is a precise companion diagnostic assay, allowing for selection of eligible HNSCC patients for treatment with pembrolizumab.
Outcome measures following Sono and Photodynamic Therapy – A Case Series
Authors: Kenyon Julian
Published: April 2021

Sono and Photodynamic Therapy (SPDT) is a novel therapeutic modality that utilises a non-toxic photosensitive agent with reported ultrasound-activated properties. SPDT has previously demonstrated significant tumour cell inhibition in animal studies. There has been much research into the efficacy of photodynamic therapy and development in understanding of the underlying mechanism of tumour cytotoxicity. Synergistic ultrasound activation represents a promising development to Photodynamic Therapy, as photo-activation is limited by access and penetrance issues. Ultrasound has been demonstrated to activate a number of sono-sensitive agents allowing the possibility of non-invasive targeted treatment of deeper tumour sites than is currently achievable with photodynamic therapy. This case series of 17 consecutive patients with a variety of cancer diagnoses outlines clinical outcomes over a four-year period of SPDT. The results have been encouraging in that all cases who carried our Circulating Tumour Cell Tests before and after SPDT showed a significant drop in tumour cells post-SPDT. SPDT is worthy of further investigation as an effective and well tolerated treatment for a wide variety of primary and metastatic tumours, including those refractory to Chemotherapy.
Uso de Tecnologías Digitales y Aula invertida en las prácticas Pedagógicas de los docentes en el grado undécimo de la Institución Educativa Instituto Montenegro
Authors: Arias González Luz Marina , Torres Quitora Luis Fernando
Published: April 2021

Esta investigación buscó determinar el uso de tecnologías digitales -TD- y Aula Invertida -AI- en las prácticas pedagógicas de los docentes del 11º de la IE Instituto Montenegro, en Montenegro, Quindío. Así, su metodología es cualitativa, de Investigación Acción Participativa. Por tanto, los resultados evidencian que muchos profesores tienen un concepto positivo sobre las TD y que varios las utilizan; mas, no hay manejo generalizado de estas-; y, algunos desconocen el AI, otros expresan que es una herramienta importante, pero se encuentran obstáculos para aplicarla: la IE no tiene recursos tecnológicos suficientes, ni conectividad permanente a internet; además, varios estudiantes no cuentan con conexión en sus hogares. Así, se concluye que las TD son pertinentes en los procesos de enseñanza-aprendizaje. Igualmente, el modelo de AI es valioso, pues permite que el estudiante desarrolle diversas competencias; además, la mayoría de docentes de esta IE hacen uso de algunos tipos de TD, pero no del AI, esto debido a las limitantes que tienen los estudiantes para acceder a internet.
Design and Realization of Automatic Warehouse Based on S7-1500PLC
Authors: Yang Fuhua , Li Haitao
Published: April 2021

In order to improve the efficiency of automatic warehouse control system,the experimental platform of stereoscopic warehouse with s7-1500plc is designed.The manipulator is driven by stepper motor and servo motor to realize x,y and Z three-axis space motion.The material transmission system is built by general-purpose G120 inverter. HMI KTP700 realizes control and status monitoring.The materials are identified and classified by RFID sensor and other sensors.TIAV15 software build PROFINET communication and PROFIBUS communication network.Using the GRAPH language programming can improve the visualization degree of application and solve the complex problems of program design and debugging of the warehouse control system.Through the design of hardware and software,a set of complete control system design scheme is formed,which has high practical value and provides an excellent teaching and experiment platform for the intelligent storage system.
Shaping Gender Equality Policies in IST-ICT Research Institutions
Reflective Negotiations from the Participatory Audit to Design of Gender Equality Plans
Authors: Sangiuliano Maria , Canali Claudia , Madesi Vasiliki
Published: April 2021

One of the critical issues highlighted by the existing literature on structural change for gender equality refers to the tensions and negotiations between the transformative goal of gender equality policies and the multiple ways they can be re-assumed and incorporated into existing policies and institutional goals. Institutional change can happen via small steps by exploiting existing discursive opportunities, or it can be overtly resisted and seen as a destabilizing factor for the status quo and existing power structures. The H2020 EQUAL-IST (Gender Equality Plans for Information Sciences and Technology Research Institutions) project supported 6 Universities across Europe starting from their Informatics and/or Information Systems Departments to initiate the design and implementation of gender equality plans from a field such as ICT/IST featured by extremely low representation of female researchers and full professors. The chapter analyzes the internal assessment phase and the preliminary steps of the initiated design process : based on a mixed methodology and a participatory approach to design gender equality policies, quantitative data collection has gone hand in hand with a qualitative Participatory Gender Audit: staff members and students discussed the main challenges related to gender inequalities and an idea generation process was kicked off. Discrepancies between the ‘diagnostic’ aspect of assessing problems and ‘prognostic’ ideas for measures and solutions are highlighted, leading to interesting insights as far as the afore-mentioned tensions are concerned.
Adapting Participatory Gender Audit to Small-Medium Sized ICT/IST Research Institutions
The EQUAL-IST Methodology
Authors: Canali Claudia , Addabbo Tindara , Sangiuliano Maria
Published: April 2021

One of the most critical phases to start a process of structural change for gender equality in a research institution is represented by the internal assessment of gender inequalities that allows to identify the main gender bias at the institutional level and may provide inputs to the design of the required measures and actions to enhance gender equality. Within the context of the EQUAL-IST project (Gender Equality Plans for Information Sciences and Technology Research Institutions), an innovative methodology for gender assessment has been developed to be adapted to research institutions with a strong component in ICT/IST. This field, recognized as one of the most affected by gender inequalities at all levels, presents peculiar issues iin terms of gender equality: in the ICT/IST field, indeed, a significant under-representation of women can be observed already at the level of the student population (Bachelor, Master and PhD); then, the gap tends to increase among the researchers and becomes more and more severe going up to the high levels of professors and top managers. In this chapter we present the gender assessment methodology developed in the EQUAL-IST project, that exploits a mixed strategy integrating two main approaches followed by existing methodologies for gender audit. On one side, a quantitative approach, based on measurable indicators computed on gender disaggregated data, is considered with the aim provide measurable and comparable information that facilitates monitoring and evaluation of gender equality policies impact over time. On the other side, the methodology integrates a qualitative approach, based on participatory techniques and tools such as focus groups, workshops, semi-structured interviews. These tools have the main objective to start raising awareness and to trigger a self-reflection process about processes and procedures, organizational culture and individuals self-perception about gender issues. The chapter presents in details the developed methodology for gender assessment, highlighting the main criteria followed for the choice of the quantitative indicators and the collaborative nature of the design and development process that, starting from the ILO PGA (Participatory Gender Audit), led to the final version of the methodology based on feedbacks received from the 7 EQUAL-IST RPOs through several steps of adaptation and customization.
Promotion of Gender Equality at the University of Muenster’s Department of Information Systems
Authors: Gorbacheva Elena
Published: April 2021

The article provides an overview of the work done at the University of Muenster (WWU), Department of Information Systems (DIS) within the Horizon 2020 EQUAL-IST project (“Gender Equality Plans for Information Sciences and Technology Research Institutions”). During the project, the existing at DIS challenges related to gender equality, diversity, and work-family balance were revealed, the objectives to address these challenges were set, and the interventions to achieve these objectives were designed, implemented, as well as continuously assessed and refined. This article provides insights into the course of project implementation at WWU, achieved outcomes, and sustainability plan.
GENERA: How to Commonly Address Gender Equality in Physics
Authors: Berghöfer Thomas
Published: April 2021

Physics research may benefit from the greater presence of talented women at all levels, however, gender awareness and gender competences are not very much developed in this research field. In September 2015, 11 physics institutes and two professional support organizations started the EU-funded H2020 GENERA project with the motto “from physicists for physicists”. After having assessed the status quo, the GENERA consortium prepared tools necessary to tailor, design and implement Gender Equality Plans (GEPs) and measures in the participating institutions. In the GENERA toolbox, for example, more than 100 good practice measures to support gender equality in physics institutions have been compiled. Supported by research on careers in physics and guided by project internal evaluation, the physics institutions created and implemented their GEPs. The GENERA project officially concluded its original three-year run on 31 August 2018. During its lifetime, GENERA has boosted awareness on the issue of gender equity in physics. A series of Gender in Physics days – one-day national events invented by GENERA and organized by the project partners – was particularly helpful and demonstrated that commonly addressing gender equality in a network is beneficial for all. This is why the partners of GENERA were setting up the GENERA Network to continue with the original project’s activities after the end of the project, and to study the impact of GENERA on physics in the long run. Meanwhile, the GENERA Community of Practice has been created as part of the EU-funded ACT project to advance knowledge and collaborate in learning on gender equality.
Тенденції розвитку конструкцій підвісок військових автомобілів
Authors: Манзяк М.О. , Крайник Л.В. , Грубель М.Г.
Published: April 2021

У статті визначено основні вимоги, які впливають на розвиток конструкцій зразків військової автомобільної техніки (ВАТ). Зокрема встановлено, що на підвищення швидкостей руху та мобільності колісної ВАТ при русі бездоріжжям загалом, впливають, як збільшення питомих потужностей двигунів, вибір оптимальних параметрів трансмісії, так і конструкції підвісок. Вібраційні та коливні навантаження на водія (екіпаж) зразків ВАТ під час руху бездоріжжям формують два визначальні аспекти застосування автомобілів. Перший аспект пов’язаний із штучним обмеженням водієм максимальної швидкості руху нижче технічної максимальної через граничну межу його дискомфорту, а другий - через відповідну втому і суттєве погіршення моторики водія (екіпажу) залежно від тривалості руху бездоріжжям. Визначено тенденцію розвитку конструкцій підвісок, яка полягає у переході від залежних підвісок з нерозрізною балкою осі і жорстким взаємозв’язком кінематики підвісок правого і лівого коліс до незалежних. Такий підхід дозволяє забезпечити підвищення комфортності в русі водія і екіпажу, а також підвищити середні швидкості руху та суттєво зменшити поперечні крени кузова. Проведено аналіз тенденцій впровадження активних і напівактивних підвісок на сучасних зразках колісної ВАТ, що дозволяє суттєво покращити комфортність екіпажу, збереженість вантажу та середні швидкості руху. За результатами досліджень встановлено необхідність переходу на довгоходові незалежні підвіски, для зменшення непідресорених мас та вібронавантаженості кузова і екіпажу.
Peculiarities of Grammaticalization of the Italian Quantifiers of Indefinitely Big Quantity
Authors: Aksenova Ksenia Alexandrovna , Oborotova Elena Viktorovna
Published: April 2021

The paper aims to identify peculiarities of the Italian quantifiers of indefinitely big quantity. Grammaticalization of quantitative lexemes is considered as a basic means to form quantifiers. The research objective is to develop a classification of the Italian quantifiers according to the degree of their grammaticalization. Scientific originality of the study lies in the fact that the Italian quantitative vocabulary is for the first time analysed through the lens of grammatical representation of the concept INDEFINITE QUANTITY. The research findings are as follows: the authors identify and describe three degrees of grammaticalization (minimum, average and maximum), propose a classification of the Italian quantifiers according to the degree of their grammaticalization.