bluuebunny/crossref_metadata_2025 huggingface dataset:
РАЗРАБОТКА СОСТАВА РАСТИТЕЛЬНО-ЖИРОВЫХ СПРЕДОВ ДЛЯ ЗДОРОВОГО ПИТАНИЯ
Authors: Тарасова Л.И. , Тагиева Т.Г. , Завадская И.М.
Published: December 2024

Концепция здорового питания и ее практическая реализация неразрывно связаны с расширением ассортимента функциональных продуктов, содержащих в своем составе ингредиенты, оказывающие благотворное воздействие на здоровье человека. В статье представлены результаты исследований, связанных с конструированием эмульсионных продуктов бутербродного назначения пониженной жирности с вводом белково-углеводных компонентов растительного происхождения. На примере белково-углеводных ингредиентов из зерен гороха и нута показана возможность создания рецептур и определены оптимальные технологические параметры изготовления растительно-жировых спредов с массовой долей жира 50 и 40%, обладающие диетическими свойствами и физиологической ценностью благодаря пониженному содержанию жира, сбалансированному жирнокислотному составу жировой фазы, отсутствию трансизомеризованных жирных кислот и обогащению полезными для здоровья функциональными ингредиентами.

The concept of a healthy diet and its practical implementation are inextricably linked with the expansion of the range of functional products containing ingredients that have a beneficial effect on human health. This article presents the results of studies related to the design of low-fat emulsion sandwich products with the introduction of protein-carbohydrate components of plant origin. Using the example of protein-carbohydrate ingredients from pea and chickpea grains, the possibility of creating recipes is shown and the optimal technological parameters for the manufacture of vegetable-fat spreads with a fat mass fraction of 50 and 40%, possessing dietary properties and physiological value due to the reduced fat content, balanced fatty acid composition of the fat phase, absence of trans-isomerized fatty acids and enrichment with healthy functional ingredients.
ИССЛЕДОВАНИЕ СТРУКТУРНО-МЕХАНИЧЕСКИХ СВОЙСТВ И СКОРОСТИ МИГРАЦИИ КОНДИТЕРСКОГО ЖИРА НА ОСНОВЕ СРЕДНЕЙ ФРАКЦИИ ПАЛЬМОВОГО МАСЛА С ДОБАВЛЕНИЕМ ВЫСОКОПЛАВКИХ ТРИАЦИЛГЛИЦЕРИНОВ ДЛЯ НАЧИНОК КОНФЕТ, ГЛАЗИРОВАННЫХ ШОКОЛАДНОЙ ГЛАЗУРЬЮ
Authors: Павлова И.В. , Коблицкая М.Б.
Published: December 2024

С целью разработки технологии производства кондитерского жира для начинок конфет, глазированных шоколадной глазурью, с минимальным содержанием трансизомеров (не более 2%) и повышенной устойчивостью к миграции жидкой жировой фазы исследованы структурно-механические свойства и скорость миграции опытных образцов кондитерского жира на основе средней фракции пальмового масла с добавлением высокоплавких триацилглицеринов. Установлено, что при содержании 2-олеодипальмитина (POP) около 55%, добавление (2-4)% высокоплавких триацилглицеринов в качестве затравочных кристаллов обеспечивает образование кристаллов триацилглицеринов в стабильной Р-полиморфной форме с тройной длиной цепи, характеризующейся наибольшей твердостью, без специального темперирования. При этом опытный образец с введением 4% высокоплавких триацилглицеринов (№ 7) наряду с минимальной продолжительностью застывания и наибольшей твердостью, обладает также пониженной скоростью миграции жидкой жировой фазы из начинки к поверхности глазированного слоя кондитерских изделий, что позволяет значительно увеличить срок годности продукции. На основании проведенных исследований разработана рецептура кондитерского жира для корпусов конфет с содержанием трансизомеров не более 2% и повышенной устойчивостью к миграции жидкой жировой фазы.

Investigation of structural and mechanical properties and migration rate of confectionery fat based on middle fraction of palm oil with addition of high-melting triacylglycerols for chocolate glazed candy fillings. In order to develop a technology for production of confectionery fat for chocolate coated candy fillings with a minimum content of trans-isomers (not more than 2%) and increased resistance to migration of the liquid fat phase, the structural and mechanical properties and migration rate of experimental samples of confectionery fat based on the middle fraction of palm oil with the addition of high-melting triacylglycerols were investigated. It was found that at the content of 2-oleodipalmitin (POP) about 55%, the addition of (2-4)% of high-melting triacylglycerols as seed crystals provides the formation of triacylglycerols crystals in the stable P-polymorphic form with triple chain length, characterized by the highest hardness, without special tempering. In this case, the prototype with the introduction of 4% of high-melting triacylglycerols (No 7) along with the minimum duration of solidification and the highest hardness, also has a reduced rate of migration of liquid fat phase from the filling to the surface of the glazed layer of confectionery products, which allows to significantly increase the shelf life of products. On the basis of the conducted researches the formulation of confectionery fat for candy coating with the content of trans-isomers not more than 2% and increased resistance to migration of liquid fat phase was developed.
КОНСОРЦИУМ МОЛОЧНОКИСЛЫХ КУЛЬТУР С ЗАЩИТНЫМ ШТАММОМ LACTOBACILLUS BULGARICUS ДЛЯ ИСПОЛЬЗОВАНИЯ В ПРОДУКТАХ ДЕТСКОГО ПИТАНИЯ
Authors: Степанова А.П. , Ловцова Л.Б.
Published: December 2024

В статье представлены исследования по созданию консорциумов молочнокислых культур с защитным штаммом L. bulgaricus для использования в продуктах детского питания. Приведены результаты по селекции и отбору штаммов L. bulgaricus и Str.ther-mophilus, и изучению антагонистической активности штамма L. bulgaricus по отношению к микроорганизмам порчи. По полученным данным было составлено два консорциума молочнокислых культур, в которых была изучена устойчивость к агрессивным воздействиям внешней среды и антибиотическая активность, также были определены биохимические и органолептические показатели. В результате исследований было установлено, что составленные консорциумы молочнокислых культур с защитным штаммом L. bulgaricus могут применяться в производстве продуктов детского питания с целью улучшения их качества и предотвращения микробиологической порчи.

The article presents studies on the creation of consortia of lactic acid cultures with a protective strain of L. bulgaricus for use in baby food products. The results of selection and selection of L. bulgaricus and Str.thermophilus strains and the study of the antagonistic activity of the L. bulgaricus strain in relation to spoilage microorganisms are presented. Based on the data obtained, two consortia of lactic acid cultures were compiled, in which resistance to aggressive environmental influences and antibiotic activity were studied, and biochemical and organoleptic indicators were also determined. As a result of the studies, it was found that the compiled consortia of lactic acid cultures with a protective strain of L. bulgaricus can be used in the production of baby food products in order to improve their quality and prevent microbiological spoilage.
О СРОКАХ ГОДНОСТИ ОРГАНИЧЕСКОЙ ПРОДУКЦИИ
Authors: Фролова Н.Н.
Published: December 2024

Обеспечение того, чтобы продукты питания оставались свежими и безопасными для потребления в течение длительного периода времени, является проблемой, которая уже давно беспокоит как пищевую промышленность, так и потребителей. Важность продления срока годности продуктов питания невозможно переоценить. Увеличение срока годности не только сокращает количество отходов, но и повышает прибыльность бизнеса и удовлетворенность потребителей. Органические продукты являются уникальными по своим качествам, поэтому особенно важно сохранять их полезные свойства с минимальными потерями. Одной из важнейших тенденций в производстве и хранении пищевых продуктов является разработка новых процессов консервирования, способных производить более питательные, свежие, менее обработанные и безопасные продукты.

Ensuring that food remains fresh and safe for consumption over an extended period of time is a challenge that has long worried both the food industry and consumers. The importance of extending the shelf life of food cannot be overstated. Increasing shelf life not only reduces waste, but also increases business profitability and consumer satisfaction. Organic products are unique in their qualities, so it is especially important to maintain their beneficial properties with minimal losses. One of the most important trends in food production and storage is the development of new canning processes capable of producing more nutritious, fresh, less processed and safe foods.
Antirabies vaccination protocol in foxes
Authors: Šnytová Jana , Codreanu Mario-Darius
Published: December 2024

Rabies is a disease transmitted by the bites of infected animals, and it can be lethal if not treated promptly. By using an attenuated vaccine, fox populations in affected areas are immunized, which limits the transmission of the virus to other animals and humans. This intervention greatly reduces the risk of exposure to rabies, thereby protecting rural and urban communities in the vicinity of these wild animals’ habitats.
Assessing the Efficacy of Mass Releases of Podisus maculiventris Treatments for Biocontrol of Mexican Bean Beetle Populations Infesting Snap Beans
Authors:   Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, USA, B Avery Pasco , Barbeau Erin ,   Entomology and Nematology, University of Florida, Institute for Agricultural Sciences, Indian River Research and Education Center, Ft. Pierce, FL, USA, Ayala Lizbeth ,   Entomology and Nematology, University of Florida, Institute for Agricultural Sciences, Indian River Research and Education Center, Ft. Pierce, FL, USA, L Lambdin Paris ,   Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, USA
Published: December 2024

all EMR treatments ranged from 60-94% compared with the DWGF treatments (0-25%) for both years. SSB nymphs become predacious as 3rd instars and the ratio of SSB 3rd instars available for EMR: DWGF middle and highest treatments at 7 days post-egg deposition (PED) was 39:1 for Year 1 and 20:0 for Year 2. A decrease in the number of SSB nymphs observed for 7 days PED was negatively correlated to heavy rainfall and other abiotic factors during both year evaluations. Overall, seasonal abundance of the MBB stages was lower on plants with the middle and highest treatment of 125 and 250 total eggs per plot for both years; however, there was no significant differences (P > 0.05) noted among means for the defoliation index. Mean pod yield was significantly greater for treatments containing 125 and 250 total eggs per plot, compared to all the different rates of dewinged gravid female releases and no release. SSB clearly demonstrated potential for use as a biological control agent against MBB populations infesting snap beans. SSB egg mass release treatments did appear to be a promising method for augmentative biological control of MBB for areas where snap beans are economically important. However, practical application of augmentative releases of SBB for control of MBB on snap beans will require further research. This will include the timing of releases, the numbers required, methods of mass production, distribution, and evaluation of field efficacy.
Hemp Crop Opportunities
Authors:   Hellenic Agricultural Organization - DIMITRA, Institute of Plant Breeding and Genetic Resources, Greece, Tsaliki Eleni , Kalivas Apostolos ,   Hellenic Agricultural Organization - DIMITRA, Institute of Plant Breeding and Genetic Resources, Greece
Published: December 2024

Hemp (Cannabis sativa L.) is the world’s most recognizable and controversial plant that was rediscovered as a sustainable and high yielding crop. Cannabis belongs to family Cannabaceae and is classified under the Cannabis genus as one species Cannabis sativa L with the subspecies C. sativa L. and C. indica Lam [11] and many varieties [15]. The mainly products of cannabis cultivation are— the bast fibers for cordage and textiles, the seeds for food and seed oil and the flowering tops for medicinal and psychoactive drugs [16]. The global market consists of more than 25,000 hemp products and new applications are continuously appearing [13].
Separation of Phycocyanin from Spirulina platensis Using a Non-Conventional System: Evaluation of Photostability and Antioxidant Activity
Authors:   Kocaeli University, Faculty of Arts and Sciences, Department of Chemistry, Section of Biochemistry, Umuttepe Campus, 41380 Izmit-Kocaeli/TURKEY., Duman Yonca , Aktürk Hilal ,   Kocaeli University, Faculty of Arts and Sciences, Department of Chemistry, Section of Biochemistry, Umuttepe Campus, 41380 Izmit-Kocaeli/TURKEY.
Published: December 2024

In present study, the combinable approach of freezing and thawing and aqueous two-phase partitioning system was designed for simple, rapid and cost friendly extraction and purification of Spirulina plantesis phycocyanin. From cell extract, C-PC was purified 1.38-fold 51.35% recovery by ammonium sulphate fractionation then PEG3000/KH2PO4/K2HPO4 system at pH 7. Contrary to expectations, increasing neutral salt concentrations resulted in decreased C-PC recovery, deviating from the typical enhancement of biomolecular partitioning performance in aqueous two-phase systems. The C-PC showed remarkable in vitro antioxidant and radical-scavenging activity. 200 µg/mL C-PC, performed a maximum absorbance by phosphomolybdenum and ferric ion reducing assay, 0.55 and 0.45, respectively. H2O2 scavenging activity was defined as 93.67%. Notably, modified C-PC (m-C-PC) exhibited improved photostability under yellow light exposure compared to unmodified C-PC, showcasing a 1.064-fold enhancement after 540 minutes. However, m-C-PC showed increased susceptibility to white light, UV-A and UV-B irradiation, suggesting a failure to enhance stability under these conditions.
Delayed Neuromuscular Recovery after General Anesthesia: A Case of Atypical Plasma Cholinesterase
Authors:   Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA, Vera-Miquilena Elvia , Lysandrou Helena ,   The Ohio State University College of Medicine, Columbus, OH, USA, Yi Sujin ,   Department of Dental Anesthesiology, The Ohio State University, Columbus, OH, USA, Soghomonyan Suren ,   Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA, Lysandrou Plato J ,   Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA
Published: December 2024

Pseudocholinesterase Deficiency (PChED), also called atypical plasma cholinesterase, or butyrylcholinesterase deficiency, is a rare genetic disorder that affects the body’s ability to metabolize ester bonds, affecting the duration of action of muscle relaxants such as succinylcholine and mivacurium. This condition may lead to prolonged paralysis after general anesthesia when muscle relaxants are used, requiring prolonged postoperative mechanical ventilation of the patient. We present a case of a 63-year-old male patient that presented for direct laryngoscopy and esophagoscopy under general anesthesia, and experienced prolonged paralysis after succinylcholine administration. PChED should be considered in cases of otherwise unexplained prolonged muscular weakness after anesthesia.
Tax pilot for self-employed: withdrawal from shadow employment for the purposes of strategic economic development
Authors: Akhmadeev R. G.
Published: December 2024

The interim results of the tax experiment implemented from 2019 to 2029 in Russia in relation to individuals belonging to the self-employed category have been summarized. The conducted research has revealed positive aspects of the experiment: increase in registered taxpayers due to the territorial feature expansion and demand for individuals to gradually build their entrepreneurial activity in the economy in the aggregate aimed at achieving the key objectives of the ongoing state policy to reduce shadow employment. The dynamic growth of the taxpayers’ number under the special regime since the beginning of the experiment is characterized by a multiple growth of 16.5 times, which in absolute terms as of January 1, 2024 corresponds to 9.279 million people, while tax revenues to the budget system have also increased significantly, amounting to 59,184.5 million rubles in absolute terms as of January 1, 2024, and the share in the total structure of special regimes has increased to 5.6%. At the same time, in order to achieve the established parameters for the self-employed number growth up to 11 million people by 2030, it is important to solve medium-term tasks aimed at improving certain provisions of the special regime: possibility of considering the payers’ length of service, insurance premiums payment on a mandatory basis while preventing an increase in the tax burden, as well as annual indexation of the maximum amount of income received by the deflator coefficient for all categories of self-employed.
AI Agents in Chemical Research: An Intelligent Research Assistant System
Authors: Ma Kangyong
Published: December 2024

This work utilizes collected and organized instructional data from the field of chemical science to fine-tune mainstream open-source large language models. To objectively evaluate the performance of the fine-tuned models, we have developed an automated scoring system specifically for the chemistry domain, ensuring the accuracy and reliability of the evaluation results. Building on this foundation, we have designed an innovative chemical intelligent assistant system. This system employs the fine-tuned Mistral Nemo model as one of its primary models and features a mechanism for flexibly invoking various advanced models. This design fully considers the rapid iteration characteristics of large language models, ensuring that the system can continuously leverage the latest and most powerful AI capabilities.A major highlight of this system is its deep integration of professional knowledge and requirements from the chemistry field. By incorporating specialized functions such as molecular visualization, SMILES string processing, and chemical literature retrieval, the system significantly enhances its practical value in chemical research and applications. More notably, the system possesses autonomous evolution capabilities. Through carefully designed mechanisms for knowledge accumulation, skill acquisition, performance evaluation, and group collaboration, the system can continuously optimize its professional abilities and interaction quality. This dynamic adaptive feature enables the system to evolve autonomously, breaking through the inherent static limitations of traditional AI systems.
A NEW AROMATICITY DESCRIPTOR BASED ON ELECTRON DELOCALIZATION EMPLOYING THE DISTRIBUTED MULTIPOLE ANALYSIS (DMA)
Authors: Siqueira Soldaini Oliveira Roberta , Souza Oliveira Marco Aurélio , Borges Jr Itamar
Published: December 2024

Aromatic compounds are energetically stable and have low reactivity, but an aromaticity concept is difficult to establish because it cannot be measured. For this reason, different descriptors have been developed to rationalize and quantify this phenomenon. Given that cyclic electron delocalization is an essential property of aromatic compounds, in this work, we propose six new aromatic descriptors based on Stone's distributed multipole analysis (DMA) to partition the molecular electron density on electric multipoles localized on different sites of a molecule. The new aromatic descriptors are based on different components of DMA quadrupole electric moment tensor Q_2, the first term of the DMA multipole expansion having contributions from the out-of-plane electron density. The proposed descriptors are straightforward to obtain because the DMA method is implemented on different popular electronic structure packages. For users of Gaussian, the formatted checkpoint with the calculated molecular electron density is used as input for the GDMA2 program of Stone to compute the necessary Q_2 components. The computer protocol for computing the Q_2-based descriptors in either way is presented. To assess the performance of the aromaticity descriptors, we used 12 tests of the Girona benchmark developed by the Solà group involving different distortions of benzene, substitutions, complexation, ring size dependence, atom size dependence, heteroatomic species, Clar systems, and fulvenes. The correct aromaticity trends of the six new indices were predicted entirely in 78% of the cases; for 16%, most trends were predicted and only failed utterly in 6%. The failed cases were related to the appreciable contribution of in-plane sigma electrons. Our proposal joins others to contribute to understanding the important and complex chemical concept of aromaticity.
Bioprocess Optimization of Lobster Waste Treatment Using Lactococcus lactis and Lactobacillus paracasei for N-polysaccharide Extraction
Authors: Okoro Oseweuba Valentine , Khalid Elza , Amenaghawon Andrew , Nie Lei , Karimi Keikhosro , Claeys Philippe , Shavandi Armin
Published: December 2024

This study focuses on optimizing microbial processes for producing nitrogenous polysaccharides, specifically chitin and chitosan, from crustacean waste using response surface methodology. Lactococcus lactis and Lactobacillus paracasei were employed as microbial strains to assess the effects of key process variables: temperature, time, and substrate concentration, on the degrees of demineralization (DD%) and deproteinization (DP%). The results showed that L. lactis achieved a DD% of 80.61% and a DP% of 41.16%, while L. paracasei demonstrated superior performance with a DD% of 88.87% and a DP% of 55.96%. Fourier-transform infrared (FTIR) spectroscopy confirmed the presence of functional groups characteristic of commercially available chitosan, underscoring the potential of these microbial strains in sustainable chitin/chitosan production. Despite these promising results, the limited proteolytic activities of both strains highlighted the need to incorporate protease-producing microorganisms or adopt a secondary deproteinization step to improve purity. This study emphasizes the potential of green chemistry approaches in enhancing chitin/chitosan extraction, paving the way for sustainable waste management and resource recovery within the seafood industry.
Dehydra-Decyclization of Tetrahydrofuran for Butadiene Across the Spectrum of Solid Acidity
Authors: Lee ChoongSze , Kumar Gaurav , Shetty Manish , Abdelrahman Omar , Tsapatsis Michael , Dauenhauer Paul
Published: December 2024

Catalytic C-O bond cleavage and dehydration of tetrahydrofuran was evaluated for a set of progressively stronger solid acid catalysts. Strong acids, namely tungsten-based heteropoly acids, exhibited higher activity and selectivity towards butadiene production than more weakly acidic zeolites; enthalpic stabilization in the controlling transition state in butadiene formation contributed to a lower apparent activation energy barrier for stronger acids. The most weakly acidic phosphorus-based zeolite (P self-pillared pentasil, P-SPP) exhibited high selectivity to butadiene (91%). Selectivity to products, mainly butadiene and propene, was controlled by the interplay of enthalpic and entropic contributions to dehydra-decyclization and retro-Prins reactions, respectively. In this balancing act, P-SPP is the least enthalpically stabilized but most entropically favourable in the butadiene formation reaction, resulting in the highly selective formation of butadiene.
Discovery and Optimization of a Novel Carboxamide Scaffold with Selective Antimalarial Activity
Authors: Wagner Alicia , Trombley Roger , Podgurski Maris , Ruberto Anthony A. , Cui Meng , Cooper Caitlin A. , Long William E. , Nguyen Gia-Bao , Marin Adriana A. , Mai Sarah Lee , Lombardo Franco , Maher Steven P. , Kyle Dennis E. , Manetsch Roman
Published: December 2024

Artemisinin combination therapies (ACTs) are critical components of malaria control worldwide. Alarmingly, ACTs have begun to fail, owing to the rise in artemisinin resistance. Thus, there is an urgent need for an expanded set of novel antimalarials to generate new combination therapies. Herein, through a virtual high-throughput screen (vHTS), cheminformatics-driven down-selection, and structure-activity relationship (SAR) studies, we have identified a 1,2,4-triazole-containing carboxamide scaffold; while the most promising triazole displayed 519 nM potency against the asexual blood stages of the parasite, this activity was unable to be surpassed. Scaffold hopping efforts then revealed three alternative cores with up to a 2.5-fold increase in potency from the aforementioned front-runner triazole. The lead compound of this class, a deuterated picolinamide, displays moderate aqueous solubility (13.4 µM) and metabolic stability (CLintapp HLM 17.3 µL/min/mg) in vitro, as well as moderate oral bioavailability (% F 16.2) in in vivo pharmacokinetic studies. Front-runners representing three cores were confirmed potent against a panel of three clinical isolates harboring different resistance profiles, suggesting a novel mechanism of action, and the lead compound displayed a slow-to-moderate rate of killing (average PRR 2.4) in a parasite reduction ratio assay, making the series appealing for further development.
Efficient discovery of new medicine formulations using a semi-self-driven robotic formulator
Authors: Ros Helena , Cook Michael , Shorthouse David
Published: December 2024

We present the discovery of new medicine formulations using a semi-self-driven robotic formulator. Solubilising drugs is a significant challenge in the pharmaceutical industry, with the majority of active molecules in development for therapies being poorly soluble. The discovery of high solubility drug formulations, required for efficacious medicines, is a highly complex challenge involving the mixing of active molecules with excipients in thousands of potential combinations. We have developed a self-driving laboratory process for the production, assessment, and optimisation of solubility of liquid formulations suitable for injectable medicines, and apply it to the example molecule curcumin. In a series of loops driven by Bayesian optimisation our system discovered 7 lead formulations with high solubility (> 10mg/mL) after sampling only 256 out of 7776 potential formulations (~3%) in only a few days. Our workflow involves the generation of a seed sample set determined by clustering, followed by subsequent formulation optimisation performed by a liquid handling robot. Beyond presenting an efficient workflow for the optimisation and discovery of new liquid formulations, this work forms the basis for a more generalised optimisation workflow that could be applied to any formulation problem in the future, including those where no prior information is known.
AI-driven de-novo design and development of non-toxic DYRK1A inhibitors for Alzheimer’s disease
Authors: González Eduardo , Varas Pablo , González-Naranjo Pedro , Ulzurrun Eugenia , Pérez Concha , Páez Juan A. , Rios-Insua David , Rodríguez Santana Simón , Campillo Nuria E.
Published: December 2024

In humans, dual-specificity Tyrosine-Phosphorylation-Regulated Kinase 1A is an enzyme encoded by the DYRK1A gene involved in various diseases, including DYRK1A syndrome, cancer, diabetes, and neurodegenerative pathologies such as Alzheimer’s disease (AD). AD is the most prevalent form of dementia, accounting for 60–80% of cases and remains an unmet medical challenge with no cure and just palliative treatments. Recent studies have identified DYRK1A as a promising therapeutic target in AD, given its involvement in multiple biological functions and its alterations correlated with AD progression. In this work, we leverage multiple Artificial Intelligence (AI) tools, including pre- dictive models and generative algorithms, to design non-toxic DYRK1A inhibitors. We construct a dual-target drug discovery framework integrating AI-driven meth- ods with classical techniques to identify novel compounds. An ensemble Quanti- tative Structure-Activity Relationship (QSAR) model is employed for predicting compound affinities, while Directed Message Passing Neural Networks (DMPNN) are used to assess toxicity. In a generative phase, a Hierarchical Graph Genera- tion model (HGG) facilitated the design of potential DYRK1A inhibitors. Promis- ing candidate molecules were refined through classical docking studies, leading to their synthesis and experimental validation. As a result, pyrazolyl-1H -pyrrolo[2,3- b]pyridine was identified as a potent DYRK1A inhibitor, leading to the synthesis of a new derivative series. Enzymatic assays demonstrated nanomolar-level inhibitory activity, while anti-inflammatory and antioxidant properties were confirmed through ORAC assays and LPS-induced pro-inflammatory response evaluations in BV2 mi- croglial cells. Pharmacological testing revealed that the mentioned compound and its derivatives exhibit significant DYRK1A inhibition alongside robust antioxidant and anti-inflammatory effects.
El seguro integral de salud
Authors: Phillips Cuba Flor
Published: December 2024

Es cierto que el cáncer avanza y nos desafía, intentando sacarnos de la línea, y a veces parece que nos supera. Cuando hablamos de alcanzar la sostenibilidad financiera, creo que no debemos verlo como un objetivo, sino como un resultado. Este resultado debe surgir de las decisiones que varios agentes, con responsabilidad, toman. Por un lado, y con un rol protagónico, están los ciudadanos, sobre quienes hemos trabajado, aunque con algunas limitaciones. Como sociedad y como Ministerio de Salud, buscamos sensibilizarlos para que no teman y busquen servicios de salud de manera temprana. Esto se relaciona con los tamizajes y la detección temprana, pero también con la capacidad de las SIPRES para responder a esa búsqueda.
(...)
Un problema adicional que afecta la sostenibilidad financiera es la cadena de procesos desde la autorización sanitaria de un producto. y el proceso continúa con la evaluación por RENETZA, que también presenta limitaciones. Me he preguntado si es adecuado que CENARES siga siendo el encargado de las compras. Quizás no lo sepan, pero CENARES, el comprador nacional, es una entidad pública con un presupuesto de 1,400 millones de soles. De ese monto, 800 millones se destinan a compras relacionadas con 14 estrategias de salud, y los otros 400 millones provienen del CIS. Sin embargo, en marzo de este año, CENARES anunció que no podía realizar compras y tampoco devolvería el dinero. Ante esta situación, los directores de hospitales tuvieron que usar fondos del SIS para no dejar a los pacientes sin medicamentos básicos. Si CENARES no mejora, la sostenibilidad financiera seguirá en riesgo.
Clausura
Authors: Alcaraz Agüero Kira , Berrospi Espinoza Francisco , Soto Florian Martin , Peña Sánchez Erick , La Rosa Huertas Liliana del Carmen
Published: December 2024

Para empezar, quiero decirles que, aunque no lo crean, cada día mueren 11 mujeres por cáncer de mama y cuello uterino. Al año, fallecen 35,000 pacientes por cáncer en el Perú. Hoy, una mujer con cáncer de mama puede demorarse muchos meses desde el primer examen en un puesto de salud para empezar a recibir tratamiento. Peor aún, en regiones alejadas de Lima, donde los médicos, recursos y equipos son escasos, pueden simplemente no llegar a tratarse nunca por falta de recursos y, aunque no lo crean, por falta de conocimiento.
(...)
Definitivamente, la actualización de los documentos técnicos es una tarea constante y un proceso iterativo que se adapta a la luz de nuevas evidencias. Lo que ha mencionado la doctora es esencial: el aporte de los especialistas en los temas es crucial. Como bien se ha expresado, no solo los salubristas deberían encargarse de las normas. Sería un contrasentido. Necesitamos la participación activa de los especialistas para poder actualizar las normas adecuadamente.
The Approach of Schools to Ethnic Diversity: The Perspective of Majority and Minority Pupils
Authors: Mlinar Karmen , Peček Mojca
Published: December 2024

The growing multiculturalism in schools in most European countries, including Slovenia, poses new challenges for both teachers and pupils. Although the Slovenian school system relies on numerous strategies and guidelines for the inclusion of minority pupils, discrimination is still an everyday issue, especially when it comes to pupils from former Yugoslav countries and Roma. The aim of the present study was to investigate how pupils (N = 897) from minority groups (Albanians, Bosniaks, Hungarians, Roma, Serbs) perceive the approach of schools to ethnic diversity in comparison to the majority group (Slovenians). Exploratory factor analysis was conducted on a self-developed scale, resulting in a twofactor solution: schools’ efforts to embrace distributive equality (F1) and to foster diversity recognition (F2). For each factor, the perceptions of minorities were compared with those of the majority. The results show statistically significant differences in the perceptions of Bosniaks and Slovenians within F1, and of Hungarians and Serbs and Slovenians within F2. Furthermore, an analysis of the differences in the perception of F1 and F2 for each ethnic group show statistically significant differences for all ethnic groups except for Hungarians. The results suggest that the Slovenian school system needs to re-evaluate its practices by making more effort to foster the recognition of diversity. By recognising and valuing diversity alongside equality, schools can better address discriminatory practices and promote inclusion, which leads to the uniqueness of each identity being respected, valued and appreciated. Possible strategies to achieve this goal are discussed.
Análisis de métricas en revista científica Ecos de la Academia con Google Analytics
Authors: Portilla Chagna Jaime , Ortiz Dávila David , Mafla Tobatr Darwin , Godoy Guevara Gandhy
Published: December 2024

Es de relevancia analizar los datos de las revistas científicas ya que cada vez el posicionamiento en los ámbitos digitales toma fuerza, más aún cuando se trata de la visualización de artículos de investigación científica, para esto es de gran ayuda las nuevas tecnologías y herramientas. El objetivo de esta investigación fue analizar las métricas de usuarios de la Revista Científica Ecos de la Academia de la Universidad Técnica del Norte UTN con la herramienta Google Analytics. Esta investigación fue cuantitativa con alcance descriptivo, el estudio se centró en determinar el número de usuarios en el sitio web, tiempo medio de permanencia, procedencia geográfica, usuarios por canales de tráfico y páginas dentro más visitadas para esto se utilizó la técnica de observación de las variables descritas en el lapso del año 2023. Según lo observación, la revista registra un aumento en el número de usuarios, alcanzando la cifra de 29000, el tiempo de interacción promedio de 1 minuto y 1 segundo con un pico registrado el jueves 6 de abril, con una duración de 3 minutos, la audiencia con Ecuador liderando seguido de cerca por México y Colombia, resalta el alcance internacional, la mayoría de los nuevos usuarios provienen de  búsqueda orgánica, también por los canales directos, la página más visitada es el artículo gastronomía historia y cultura afrodescendiente. Basándose en resultados obtenidos se concluye que es valiosa la evolución de la revista. La aplicación de estos hallazgos en áreas como estrategias de comunicación, contenido temático y experiencia del usuario puede consolidar la posición actual, y también impulsar su crecimiento y relevancia en la comunidad científica digital en el futuro. La atención a estos aspectos y la adaptación ágil a cambios en las tendencias y comportamientos son esenciales para mantener una presencia exitosa en el entorno digital
El Marketing digital y su aporte a la comercialización caso: Avícola Aviburz
Authors: Piloso Karen , Zambrano Carreño Andrés Antonio
Published: December 2024

Las organizaciones agroproductivas de Manabí muestran debilidades en su administración, gestión estratégica y conocimiento del marketing digital. Durante la pandemia, la mayoría de los negocios implementaron el uso de las redes sociales, mostrando la necesidad de fortalecer las estrategias digitales de marketing. En el sector avícola específicamente existen falencias en la gestión de comercialización que limitan su competitividad, en este contexto la granja avícola Aviburz ha tenido resultados insatisfactorios en ventas a pesar de utilizar las redes sociales, lo que sugiere una mala aplicación de estrategias digitales para la comercialización. De ahí surge la pregunta de investigación sobre cómo las estrategias de marketing digital pueden contribuir a este proceso de marketing. La investigación tuvo como objetivo establecer estrategias de marketing digital que contribuyan a la comercialización en la avícola Aviburz del cantón Bolívar. La metodología aplicada se basa en una investigación cualitativa, la cual incluyó técnicas como la entrevista para conocer las estrategias existentes en la empresa y el modelo OGSM para planificar acciones de marketing digital. Se utilizaron herramientas como un software de gestión de referencias bibliográficas, además de Publish or Perish para buscar información en bases de datos científicas y Atlas T.I. para el análisis cualitativo de recursos bibliográficos. Los resultados permitieron fundamentar teóricamente las estrategias de marketing digital y de la comercialización. Por otro lado, se determinaron oportunidades de mejora en la estrategia de marketing digital de la empresa. Finalmente se desarrollaron estrategias mediante un brief de marketing digital y el modelo OGSM, además de diseñar contenidos publicitarios para impulsar la comercialización en la avícola Aviburz del cantón Bolívar.
Análisis de ruido con series de tiempo de la Red GNSS de monitoreo continuo del Ecuador (REGME)
Authors: León Lara Gustavo Roberto , Luna Ludeña Y Marco Patricio
Published: December 2024

La investigación explora las series temporales de la Red GNSS de Monitoreo Continuo del Ecuador (REGME) para identificar el tipo de ruido presente. Se emplearon datos de las 52 estaciones de la red, mismos que fueron obtenidos del portal del Sistema de Referencia Geodésico para las Américas (SIRGAS). Tras un análisis inicial de la duración de los datos, se identificaron 16 estaciones viables para el estudio, descartando las demás debido a datos insuficientes o anómalos. Estos datos seleccionados se depuraron para eliminar valores atípicos y completar los faltantes. Posteriormente, se aplicó un análisis de descomposición lineal a las series temporales para calcular tendencias, estacionalidades y, especialmente, el ruido, utilizando transformadas de Fourier. Se concluyó que ninguna estación presentaba ruido blanco, siendo común encontrar ruido rosa o flicker en la mayoría, típico de estaciones de monitoreo continuo. Sin embargo, algunas estaciones, como GZEC y SIEC, mostraron un tipo de ruido rojo o random walk, con índices espectrales cercanos a -2, atribuido a la estabilidad del monumento o el tipo de suelo en el que se encuentran empotradas las estaciones.
The effect of impactor shape on low velocity impact behavior of cylindrical sandwich structures with trapeozidal core
Authors: Bozkurt İlyas
Published: December 2024

The aim of this study is to investigate the impact performance of a cylindrical sandwich structure with Trapeozidal core under different geometries of impactors using the finite element method. The effects of impactor shape, facesheets thickness and impact point on peak contact force, absorbed energy efficiency, maximum displacement and damage deformation are investigated. Progressive damage analysis based on the Hashin damage criterion was performed using MAT 54 material model in LS DYNA finite element program for low velocity simulations. The impact behavior was investigated by creating a Cohesive Zone Model (CZM) based on bilinear traction-separation law while providing the connection between the core structure and its surfaces. At the end of the study, it was determined that the contact force values at P2 were higher than P1. Peak force variation values for cylinder, cone and sphere tipped impactors at P1 and P2 points were 43.5%, 132.3% and 62.2%, respectively. Core support has a significant effect on the contact force. The peak force value and energy absorption efficiency value obtained with the Cone impactor are higher than the others. For all three impactors, it was determined that the largest and dominant damage type was matrix damage.
“WHAT BINDS YOU TOGETHER AS WOMEN?”: SEX EDUCATION’S SEXUAL ASSAULT STORYLINE AS A #METOO NARRATIVE
Authors: Salinas Torres Belén
Published: December 2024

This article delves into the didactic potential of the sexual assault storyline found in the second season of Sex Education (Nunn, 2019-2023). Specifically, it examines how this narrative facilitates the recognition of such traumatic experiences and portrays an ideal response of sorority through a liberal feminist lens, echoing the #MeToo movement within the context of fourth-wave feminism. To this end, the essay analyses the evolution of cinematic representations of sexual violence over time, focusing on its current depiction after the ignition of the #MeToo movement. Subsequently, an analysis of the five-episode storyline explores the trajectory of trauma, from its actual perpetration until the point when the victim/survivor begins her healing journey, emphasising the long-time impact of the aggression and its psychological consequences. The essay concludes that this process demands the victim to redefine her identity, representing an empowerment quest towards a more educated, aware, and multi-faceted version of herself.
UNA SOCIEDAD SIN GÉNERO ¿ES ESO POSIBLE DE IMAGINAR? EL LEGADO DE SHULAMITH FIRESTONE Y MONIQUE WITTIG PARA LOS FEMINISMOS DEL PRESENTE
Authors: Coloma Aceña Pilar
Published: December 2024

¿Es posible imaginar una sociedad sin género y sin diferencia sexual? En busca de respuestas, el presente artículo se traslada al contexto de finales de los sesenta en Estados Unidos y Francia y, en concreto, a dos feministas radicales del incipiente Movimiento de Liberación de las Mujeres: Shulamith Firestone y Monique Wittig. Ambas escribieron obras con las que ser capaces de imaginar esta (im)posible sociedad: Las guerrilleras, publicada por Wittig en 1969, y La dialéctica del sexo, por Firestone, en 1970. Su legado resulta importante para la comprensión de muchos de los debates entre los feminismos del presente, en torno a la complejidad de las categorías de identidad o en torno al sujeto del feminismo.
 
------
Trabajo ganador del XXVII Premio de Investigaciones Feministas "Concepción Gimeno de Flaquer".
On infosuasion, news framing and proximization: Integrating a cognitive perspective and corpus analysis
Authors: Tosik (Kopytowska) Monika
Published: December 2024

Given the well-established fact that news is not “facts” but an opinionated representation of events, individuals, and issues, and thus the subjective and infosuasive nature of news reporting, we need a deeper exploration of how media frame and construct narratives to shape public perception. In the present paper we depart from the assumption that journalists create context for the audience by proximizing (bringing cognitively and affectively closer) selected aspects of reality. In this process, which consists among others in providing frames of reference – highly stereotyped representations of specific situations – media influence the frames used by the audience when interpreting information about events and problems. Adopting a cognitive linguistic perspective and drawing on the insights from the Media Proximization Approach, the article investigates the way in which frames are cognitively and discursively “to define problems, diagnose causes, make moral judgments, and suggest remedies” (Entman 1993: 52) when reporting on terrorism in Africa. The main questions addressed in the paper are as follows: (1) How is terrorism in East Africa brought closer to Western audiences? (2) How is the representation of terrorism manifested in keywords and word co-occurrence patterns? (3) How do the media frames potentially impact on the frames gene-rated by the audience? The study combines quantitative and qualitative methods, demonstrating that keyword analysis, conducted with the tools provided by corpus linguistics, constitutes an important initial step in the investigation of the frame-building and frame-setting process, shedding light on the infosuasion dynamics and strategies. The analyzed corpus includes U.S. television (ABC, NBC, CBS, Fox News, MSNBC, and CNN) news transcripts on Garissa University College attack in Kenya in 2015.
Colours as opinion markers: A case study of green
Authors: Redzimska Joanna
Published: December 2024

One of the primary functions of natural language is to express a diverse array of ideas, thoughts, and opinions. This article focuses on evaluative and assessing language conveyed through various modes of communication, including gestures, sounds, and visuals, with a particular emphasis on words. Consequently, depending on the communicative aim, opinionated language can manifest as either an offense or a compliment. Additionally, opinions may be articulated through single words or entire utterances. This text aims to elucidate, through qualitative analysis, the role of selected colour terminology in the expression of opinions, particularly those associated with the colour green. The research posits that colour terminology enhances the axiological aspects of specific language forms and, as a result, may function as an opinion marker.
Decoding gender bias through a textual exploration of Reddit /r/MensRights community
Authors: Solska Dagmara , Sawicki Jan
Published: December 2024

With a specific focus on the /r/MensRights subreddit, the linguistic landscape of the “manosphere” is examined to identify and analyze patterns of sexist rhetoric. The “manosphere” on Reddit refers to a collection of communities that discuss perceived men’s issues, often characterized by themes of men’s rights activism and anti-feminism. Employing natural language processing techniques and transformer models for sentiment analysis, the research uncovers prevalent language structures indicative of gender bias within this community. Utilizing n-gram analysis, the aim is to provide insights into the language dynamics contributing to the perpetuation of gender-based discourse. By examining the framing of gender issues and opinionated language, the research aims to shed light on how members of the men’s rights community discuss gender issues, including attitudes towards feminism, perceptions of male-related issues, and overall perspective surrounding men and women. This study strives to contribute to a broader understanding of online communities and their influence on shaping attitudes towards gender.
Good teaching practices on the example of chemistry teaching in non-chemistry studies
Authors: Gryglik Dorota
Published: December 2024

The article examines the primary pedagogical challenges currently en-countered by university educators and explores selected instructional methods that can enhance the quality of education. It outlines specific strategies and interventions designed to increase student engagement during classes, with a particular focus on the case study involving Chemistry lectures for Sanitary Engineering students in the Environ-mental Engineering program within civil construction. The positive outcomes, both in terms of activating student participation and im-proving learning efficiency, were corroborated over several years of ob-servation. The findings demonstrate that, with an appropriate peda-gogical approach, it is possible not only to impart knowledge but also to foster engagement, motivation, and positive relationships that con-tribute to the holistic development of students. The article highlights the importance of continuous improving of educators’ teaching com-petencies and adapting curricula and instructional methods in order to meet the rapidly evolving demands of the labour market.