bluuebunny/crossref_metadata_2025 huggingface dataset:
REAL CLINICAL PRACTICE OF TREATMENT OF CARDIAC ARRHYTHMIAS IN LOCOMOTIVE CREW WORKERS
Authors: Batishcheva Galina Alexandrovna , Korchagina Sofia Alekseevna , Kotelnikova Tatyana Evgenievna , Goncharova Natalya Yurievna Natalya Yurievna
Published: December 2023

Cardiac arrhythmias create prerequisites for the occurrence of sudden cardiac death in the workplace, which poses a threat to the safety of train traffic. A targeted examination of locomotive crew workers (LCW) includes the diagnosis of cardiac arrhythmias for effective and safe pharmacotherapy. A retrospective analysis of 100 medical histories of machinists and assistant machinists hospitalized in the cardiology department of the Private healthcare institution "Clinical Hospital "Russian Railways-medicine" Voronezh", who have the following types of cardiac arrhythmias: supraventricular extrasystole (single 94%, paired 20%), single ventricular extrasystole 51%, paroxysmal form of atrial fibrillation 2%, conduction disorder 6%. According to the results of the examination, a group of LCW with prognostically unfavorable cardiac arrhythmias (32%) was identified, who underwent pharmacotherapy, including beta-blockers, antiarrhythmic drugs of class IC and class III. The choice of medications for pharmacotherapy in outpatient settings took into account the impact on professionally important functions according to the established List of "Medicines and traffic safety" (ed. from 2016). At discharge, 25% of patients were recommended nebivolol, which LCW could take in conditions of professional activity. Pharmacotherapy of drivers on an outpatient basis was continued with etacizine (3%), allapinine (2%), amiodarone (1%) with suspension from work for the period of taking the drug.
REVIEW OF SURFACTANT DELIVERY STRATEGIES IN NEONATOLOGICAL PRACTICE
Authors: Ippolitova Lyudmila Ivanovna , Korotaeva Natalia Vladimirovna , Pershina Elena Sergeevna , Panichev Konstantin Vladimirovich , Lobanova Olga Alekseevna , Dilbaryan Artem Aleksandrovich
Published: December 2023

Administration of surfactant by minimally invasive techniques that promote spontaneous breathing may be safer and more effective than administration with endotracheal intubation and mechanical ventilation. At present, the use of INSURE and LISA/MIST methods is well researched and widely used, their effectiveness has been largely proven and beyond doubt. However, current trends towards greater use of non-invasive respiratory support in surfactant-deficient preterm infants have created a demand for similar non-invasive methods of administering exogenous surfactant, one of which is the potentially promising method of inhaled delivery of a substance to the lungs using a nebulizer.
CONTENT ANALYSIS OF THE STRUCTURE OF THE ASSORTMENT OF SEDATIVE MEDICINES FOR THE TREATMENT AND PREVENTION OF NEUROGENIC DISEASES
Authors: Afanasyeva Tatiana G. , Kushnir Alena Yu.
Published: December 2023

The results of the content analysis of the study of the Russian pharmaceutical market of sedative medicines are presented. The main aspects and trends in the development of the range of medicines have been established.
SAFETY OF HYPOGLYCEMIC THERAPY IN CASES OF PATIENTS WITH POLYMORBID PATHOLOGIES
Authors: Goncharova Natalia Yu. , Cherenkova Olga V. , Roshchevkina Maria S.
Published: December 2023

Impairment of the excretory function of the kidneys was revealed in 69% of patients with type 2 diabetes admitted to the hospital in therapeutic departments. A decrease of GFR below 30 ml/min/1,73 m2, which can significantly affect the choice and dosage regimen of hypoglycemic drugs, was recorded in 35% of patients. According to the anamnesis, sulfonylurea derivatives took 66.3% of hospitalized patients, biguanides in monotherapy - 25%, a combination of drugs from these two groups was prescribed in 35% cases. According to the analysis of the pharmacotherapy, 8.2% of patients with type 2 diabetes mellitus required correction of hypoglycemic therapy because of the functional state of the kidneys. According to the results of laboratory research methods , during hospitalization 3% of patients had episodes of hypoglycemia ( blood glucose level 3.9 mmol/L) or boundary values of glucose (blood glucose level = 4.0-4.1 mmol/L), but endocrinologist consultations and drug therapy correction hadn't been carried out. Therefore the lack of care of 'non-endocrinologists' regarding the risk of hypoglycemia in patients with type 2 diabetes with renal dysfunction leads to the absence of pharmacotherapy correction during hospitalization.
THE ROLE OF THE INTESTINAL MICROBIOTA IN THE DEVELOPMENT OF INFLAMMATORY DISEASES OF THE INTESTINE
Authors: Lagutina Svetlana N. , Zuikova Anna A. , Chizhkov Pavel A. , Syromyatnikov Mikhail Yu. , Esina Elena Yu.
Published: December 2023

Inflammatory bowel diseases (IBD) occupy a leading position in the structure of diseases of the gastrointestinal tract (GIT), as they are a progressive chronic pathology with an autoimmune type of inflammation. Changes in indicators of genus - species biodiversity can determine morphological changes at the latent stage of the disease. Target. Evaluation of the role of genus - species biodiversity of microbiota in patients with IBD. Materials and methods. Performed 16s-rRNA sequencing of the gut microbiota in 15 patients with confirmed ulcerative colitis (UC) and 3 patients with Crohn's disease and 20 healthy controls. Also, an analysis of the parameters of the general blood test (CBC), biochemical blood test (C - reactive protein (CRP)) was carried out. Statistical data processing was carried out using Statistics programs. Results. Among the studied laboratory parameters in patients with IBD, there was a significant increase in CRP - 19.61.5 mg/l, leukocytosis - 11.40.68 g/l, including neutrophilosis - 742,1% according to compared with the control group. As a result of sequencing of the intestinal microbiota, there was a decrease in the normobiota, as well as an increase in the representatives of the pathogenic cluster. Conclusion. A decrease in the biodiversity of the microbiota in patients with IBD compared with the control group, a significant change in the pathogenic cluster, an imbalance in the representatives of Bacteroidetes and Firmicutes were revealed, which confirms the role of the intestinal microbiota in the development of IBD.
ASSESSMENT OF THE RATIONALITY OF PHARMACOTHERAPY IN ELDERLY PATIENTS WITH CARDIOVASCULAR DISEASES USING STOPP/START NON-COMPLIANCE MODELS
Authors: Popovskaya Daria P. , Shevtsova Veronika I. , Shevtsov Artem N. , Zuikova Anna A.
Published: December 2023

Elderly patients, due to involutive changes in the body, have peculiarities of pharmacokinetics and pharmacodynamics, which must be taken into account when prescribing drugs. There are various tools for individualizing therapy: use the 7-step algorithm, STOPP/START criteria, anticholinergic load scales, assessment of triggers of undesirable events - GerontoNet scale, Brighton Adverse Drug Reactions Risk scale. The article examined the use of STOPP/START criteria by physicians in practical activities. It is determined that doctors pay more attention to STOPP criteria when treating the patient and prescribing drugs. It is determined that doctors pay more attention to STOPP criteria when treating the patient and prescribing drugs. Based on the data obtained during the assessment of the use of the rational pharmacotherapy tool, prognostic non-compliance with the criteria was calculated and the factors affecting this were determined: BMI for (for STOPP criteria) and a score on the Age Not Hindrance questionnaire (for START criteria).
CLINICAL EFFICACY OF INCLUSION OF THE METABOLITE MESXIDOL IN THE REGIMEN OF TREATMENT OF INFLAMMATORY DISEASES COMPLICATED BY THE DEVELOPMENT OF PURULENT PROCESSES
Authors: Zemskova Veronika A.
Published: December 2023

The clinical effectiveness of two therapy regimens of patients with one of the diseases pyoderma, adnexitis or soft tissue infection complicated by purulent processes was assessed. The first scheme provided for the use of basic therapy according to clinical recommendations, the second was supplemented by the metabolist Mexidol.

The results of analysis of pharmacotherapy of 162 patients divided into groups according to the nosological affiliation of diseases and subhorupa according to the therapy regimen were used.

It has been found that the additional prescription of Mexidol metabolic to patients to the standard significantly increases the effectiveness of complex treatment.
HAEMATURIA DETECTABLE IN OUTPATIENT CHILDREN AND TEENAGERS: THE FREQUENCY AND POSSIBLE REASONS
Authors: Balalaeva Irina Yu. , Budanovа Margarita V. , Shvyrev Anatoliy P. , Ippolitova Lyudmila I. , Chernitsyn Igor M.
Published: December 2023

Determining the cause of haematuria in children often causes significant difficulties, especially for outpatients, due to the large number of diseases with increased quantity of red blood cells in urine and complexity of such patients examination.

The frequency and features of haematuria have been defined in outpatient children and teenagers. The frequency of haematuria in 2018-2021 was on average 4,5 %, increasing significantly from 2,4 % in 2018 to 8,3 % in 2021. The most cases of haematuria after a hot summer can relate to increased concentration of salt components in urine due to insufficient drinking intake. Haematuria identified in outpatient children was not a manifestation of severe diseases with poor prognosis (tumors, tuberculosis). It was small, transient, and disappeared in most patients after increased fluid intake, nutrition and physical activity correction, antibacterial medicines and phytotherapy appointment in urinary tract infection
A CLINICAL CASE OF ADVERSE EVENTS AFTER IMMUNIZATION AGAINST A NEW CORONAVIRUS INFECTION
Authors: Gabbasova Natalia V. , Mamchik Nikolay P. , Yatsenko Lilia A. , Mazina Olga L. , Kameneva Olga V. , Knyazeva Viktoria A.
Published: December 2023

A 20-year-old girl was immunized against COVID-19 with Sputnik V. 6 hours after vaccination, symptoms of intoxication, body aches, weakness appeared, body temperature increased to 40.3С during the day, pain was noted at the injection site. The post-vaccination reaction lasted 2 days. The patient did not seek medical attention.

The girl received the second dose of the vaccine on the 21st day after the first vaccination. 6 hours after immunization, symptoms of intoxication, body aches, weakness appeared, body temperature increased to 40.6C, pain was noted at the injection site. The next day she asked for medical help at the clinic, diagnosed with: Post-vaccination reaction to the Sputnik-V vaccine; symptomatic therapy was prescribed. The body temperature was 37.0-38.0C for 2 weeks.

Despite the superstrong general post-vaccination reaction, revaccination was carried out six months later. After the introduction of the vaccine, the body temperature increased to 41.6C, there were pronounced symptoms of intoxication, body aches, weakness, at the injection site - hyperemia, soreness, swelling of more than 8 cm in diameter. The next day, the student asked for medical help, an infectious disease doctor diagnosed her with an allergic reaction to the Sputnik V, Sputnik Light vaccine, and symptomatic treatment was prescribed. Body temperature remained febrile for 6 days, general symptoms persisted for 2 weeks, and local reactions persisted for 3 weeks.
USING OF RISK PROGNOSTIC MODEL FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATIONS IN PERSONALIZED REHABILITATION PROGRAMS DEVELOPMENT
Authors: Fateeva Oksana V. , Prozorova Galina G. , Kozhevnikova Svetlana A. , Tribuntceva Lyudmila V.
Published: December 2023

COPD is one of the leading causes of death worldwide and a serious burden on the health system. Exacerbations are a critically important feature of COPD. In GOLD (2022), a strategy was proposed for clinical practice based on treatable traits, which include persistent dyspnea and exacerbations. Their assessment underlies the algorithm of pharmacological treatment, but there are many more pulmonary and extrapulmonary signs united by common pathogenetic mechanisms and the role of biomarkers, as well as behavioral/social risk factors that deserve individual attention and treatment. Thus, medical professionals need to take a proactive position in the search for individual treatable traits to reduce the risk of disease exacerbations and an unfavorable prognosis of life in COPD patients.
Purpose. To assess the clinical efficiency of using of risk prognostic model for COPD exacerbations in personalized rehabilitation programs development.
Materials and methods. 106 patients with COPD aged 18 to 80 years were examined. The examination of patients included an assessment of outpatient exacerbations and hospitalizations to medical organizations number, an assessment of COPD Assessment Test (CAT), a subjective assessment of the insomnia severity according to Insomnia Severity Index, an assessment of laboratory parameters IL-4, IL-6, IL-8, CRP, TNF-, surfactant protein D, melatonin in urine. Statistical data processing by STATGRAPHICS 18.
Results. In according to GOLD (2023), 90 patients (84.9%) were classified as high risk of exacerbations group E. Using the original regression equation, the probability index of COPD exacerbation during 1 year of follow-up was calculated, which turned out to be high, i.e. 2 or more exacerbations of COPD were predicted during 1 year of follow-up (Prog_ex_COPD = 8,21831,13). As a prevention of possible COPD exacerbations, individual rehabilitation programs were applied during 1 year of follow-up: modification of therapy, personalized programs to optimize physical activity, vaccination against influenza and pneumococcal infection, course intake of melatonin. After 1 year of follow-up, the analysis of the assessed indicators in patients with COPD showed a significant positive trend (p˂0.05). The calculation of Prog_ex_COPD according to the original regression equation showed a low risk of COPD exacerbations with the number of exacerbations less than 2 times a year and was 3.62351.24.
Conclusions. The developed risk prognostic model for COPD exacerbations has shown clinical efficacy and can be used in the management of COPD patients with frequent exacerbations. The addition of melatonin improves the quality of sleep, which has a positive effect on reducing the symptoms and exacerbations of COPD. For COPD patients with frequent exacerbations, it is advisable to develop individual rehabilitation programs to improve control, taking into account treatable traits.
Dynamic Monitoring of Immunobiochemical measurements in Patients with Novel Coronavirus Infection having therapy with Favipiravir
Authors: Kostenko Stanislav M. , Tulinova Irina A. , Zemskov Andrey M. , Dushkina Natalya V. , Mukha Tatiana A. , Kostenko Dmitry S. , Zotova Elena E.
Published: December 2023

Delayed innate and adaptive immune response lay behind the pathogenesis of the novel coronavirus infection. COVID-19 is a multisystem disease affecting various human organs. More than a third of the patients have hepatic impairments. This can be caused by both direct cytopathic effect and immune-mediated mechanisms. In the Russian Federation, favipiravir, a DNA-Dependent RNA Polymerase inhibitor, is recommended for etiotropic therapy of the novel coronavirus infection. Research shows that the medication can reduce the viral load and the length of hospital stay. However, the affect of favipiravir on the immune response remains uncertain.
ABC/VEN – ANALYSIS OF DRUG PROVISION OF SMALL CELL LUNG CANCER CHEMOTHERAPY REGIMENS
Authors: Berezhnova Tatiana A. , Moshurov Ivan P. , Shinkarev Sergey A. , Lunyova Elena A. , Borisov Vladimir A.
Published: December 2023

This work is aimed at conducting a pharmacoeconomical analysis of chemotherapy for small cell lung cancer using ABC/ VEN analysis to identify the most expensive chemotherapy regimens. A retrospective evaluation of chemotherapy regimens for small cell lung cancer at various stages of the disease was carried out, presented in 408 case histories of patients who were treated from January 2021 to December 2021 in oncological dispensaries of the Voronezh and Lipetsk regions. During the study, the main regimens used in chemotherapy were identified and the most expensive treatment regimen for small cell lung cancer was determined, for which 50-70% of the budget is spent this is the scheme: etoposide + carboplatin and the least expensive group of drugs, for which 5-10% of the budget is spent this is scheme 3: cyclophosphamide 1000 mg/m2 in the 1st day + doxorubicin 50 mg/m2 on day 1 + vincristine 1.5 mg/m2 on day 1.
USE OF INDIVIDUAL PREDICTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATIONS IN OBESE PATIENTS DURING DISPENSARY OBSERVATION
Authors: Fateeva Oksana V. , Prozorova Galina G. , Kozhevnikova Svetlana A. , Tribuntceva Lyudmila V.
Published: December 2023

COPD is one of the main public health problems. 40.0% of all COPD patients tolerate at least 1 moderate or severe exacerbation within a year, and up to 16.0% - 2 or more. GOLD (2022) proposed for clinical practice a strategy based on "treatable traits," the key of which are exacerbations and persistent shortness of breath, but there are other numerous pulmonary and extrapulmonary features, the definition and consideration of which is useful when leaving individual management algorithms for patients with COPD.

Purpose. To evaluate the clinical effectiveness of the use of individual prediction of COPD exacerbations in obese patients during clinical observation.

Materials and methods. 106 people diagnosed with COPD between the ages of 18 and 80 were examined. The patient examination included an assessment of the number of outpatient exacerbations and hospitalizations to medical organizations over the past 12 months, a BMI calculation, a comprehensive assessment of COPD symptoms with CAT, the functional status of patients, and an assessment of biochemical blood parameters. Results. According to the examination results and BMI calculation, 80 patients (75.5%) were overweight (55 patients) or obese of various degrees (grade 1 obesity - 21 patients, grade 2 - 1 patient and grade 3 - 3 patients). According to GOLD (2023), all patients were classified as "high risk of exacerbations" - group E. The probability index of COPD exacerbation was calculated over the next 12 months using regression analysis. To prevent predicted exacerbations of COPD, individual treatment and rehabilitation programs were developed for patients, designed for use for 12 months of follow-up: treatment modification, personalized programs for optimizing physical activity, dietary recommendations, vaccination against influenza and pneumococcal infection, course therapy with melatonin, consultation with an endocrinologist. At the end of 12 months, compliance with the recommendations of the index of the probability of exacerbation of COPD for the next 12 months was low.

Conclusions. In patients with frequent exacerbations of COPD, in order to achieve disease control, it is advisable to develop individual treatment and rehabilitation programs within the framework of clinical observation, given the "treatable signs," the correction of which has a significant positive effect on the course of COPD, achievement of control and prognosis of the disease.
PREDICTION OF THE RISK OF ANTIBIOTIC RESISTANCE OF UROPATHOGENS IN PATIENTS WITH URINARY TRACT INFECTIONS
Authors: Smolyaninova Daria S.
Published: December 2023

Urinary tract infection is the most common disease in urological practice. The growth of antibiotic resistance in general and in urological practice in particular determines the need to develop methods for determining the risks of the presence of microflora resistance to antimicrobial drugs. The article discusses the existing methods for predicting the resistance of microorganisms to antibiotics, as well as the risk factor for antibiotic resistance developed by the author in community-acquired urinary tract infections. This indicator takes into account the individual characteristics and clinical and laboratory data of the patient with urinary tract infections that occur against the background of urolithiasis.
COMPARATIVE ASSESSMENT OF THE RISKS OF FATAL AND NON-FATAL CARDIOVASCULAR EVENTS USING THE SCORE/SCORE-2 SCORE IN PATIENTS WITH CARDIOVACULAR PATHOLOGY
Authors: Lagutina Svetlana N. , Zuikova Anna A. , Esina Elena Yu. , Dobrynina Irina S. , Muravitskaya Marina N. , Khanina Elena A. , Shevtsova Veronika I. , Shevtsov Artem N. , Korchagina Nadezhda S. , Chizhkov Pavel A.
Published: December 2023

The main morbidity and mortality in the world is associated with pathologies of non-infectious origin, most of which are accounted for by diseases of the cardiovascular system. For the purpose of screening, a rating scale is currently used - SCORE. In 2021, the forecasting model was improved - the SCORE2 rating scale was released, which allows you to predict the risk of complications at an early stage using additional criteria. The purpose of the study: analysis of the risk assessment of cardiovascular events using the SCORE / SCORE - 2 scales. Materials and methods. A retrospective analysis of 140 patients' medical records was carried out. The inclusion criterion was the age of more than 40 years, the absence of concomitant cardiovascular diseases. Results. There were significant differences in Score (Men=9.5 points, Interwomen=3 points, p0.001) and SCORE2 (Men=22 points, Interwomen=18 points, p=0.049) between men and women aged 50 to 70 years old. When calculating, it turned out that most patients are at moderate risk of cardiovascular complications according to the SCORE scale, at very high risk according to the updated SCORE2 algorithm. Conclusion. In the course of comparing the 10-year risk of cardiovascular events calculated using the new SCORE2 algorithm, significant differences with the SCORE scale in digital values were revealed. All smokers, regardless of age and gender, were at very high risk, which absolutely increases the risk of complications.
Outpatient use of the kansas questionnaire for patients with cardiomyopathy (kccq) and comparing its results with the shock scale
Authors: Shevtsova Veronika I. , Kolpacheva Marina G. , Zuikova Anna A. , Salamatova Valeria N.
Published: December 2023

The data obtained during the assessment of the subjective state of patients suffering from CHF FC III-IV, using the Kansas questionnaire for patients with cardiomyopathy (KCCQ), and the assessment of the objective state of patients using the SHOCK scale are compared.
CLINICAL CASE OF FAMILIAL TUBEROUS SCLEROSIS
Authors: Filina Gayane R. , Filin Andrey A. , Fedotova Tatyana V. , Mashneva Elena Yu. , Chibisova Nadezhda A.
Published: December 2023

Relevance. Tuberous sclerosis is a genetic disease with an autosomal dominant type of inheritance, characterized by the presence of benign tumors in various organs, a progressive course leading to disability and a decrease in life expectancy.
Clinical case. The pregnant's MRI of the brain revealed the presence of tubercles in the area of the cerebral cortex. At the time of 34 weeks of pregnancy, the presence of endocardial nodular formations in the fetus was revealed prenatally. MRI of the fetal brain showed the presence of a subependimal node in the area of the basal nuclei on the left. Postnatally: MRI-picture of multiple cortical-subcortical tubers, subependimal nodes, ECHO-CG-picture of multiple formations in the cavities of the heart. DNA diagnostics: the extended deletion of the TSC2 gene was determined.
Discussion. During ultrasound of the 3rd screening of the fetus, large endocardium formations were found, which made it possible to suspect tuberous sclerosis. During the examination of the newborn, the diagnostic assumptions identified prenatally were confirmed. Since tuberous sclerosis has an autosomal dominant type of inheritance, it can be assumed that the pregnant has a high probability of having the same diagnosis.
Conclusion. An integrated approach to the diagnosis of this disease allows you to pay attention to the patient in a timely manner and choose the appropriate treatment tactics.
HEALTH STATUS OF NEWBORN CHILDREN FROM MOTHERS WITH GESTATIONAL DIABETES MELLITUS IN THE EARLY NEONATAL PERIOD
Authors: Ippolitova Lyudmila I. , Kogutnitskaya Marina I. , Chistotinova Tatyana G. , Sulina Milana V. , Kolganova Anastasia I. , Aladkina Tatiana A.
Published: December 2023

Gestational diabetes mellitus is closely associated with the risk of obstetric and neonatal complications, which may be due to higher birth weight in the child, and is also increasingly recognized as a risk factor for cardiometabolic diseases in expectant mothers and their children. An increase in the number of pregnant women with gestational diabetes mellitus increases the risk of complications during pregnancy and childbirth, and also has an adverse effect on the physical development of the fetus, and may also adversely affect the course of early adaptation. The object of the study are newborns from mothers with gestational diabetes mellitus. The study includes an analysis of the developmental histories of 70 newborns from mothers with GDM, who were under observation in the Perinatal Center of the city of Voronezh. Most children from mothers with gestational diabetes mellitus have normal indicators of physical development, which can be explained by the improvement and change in approaches to the diagnosis of carbohydrate metabolism disorders during pregnancy and the effectiveness of the therapy during pregnancy.
Immediate and delayed complications of transarterial chemoembolization with drug-saturable microspheres in unresectable liver tumors
Authors: Zvezdkina Elena Aleksandrovna , Kedrova Anna Genrikhovna , Lebedev Dmitry Petrovich , Panchenkov Dmiry Nikolaevich , Аstakhov Dmitry Anatolievich , Stepanova Yulia Aleksandrovna
Published: December 2023

Backgraund: For many years of world experience in the use of transarterial chemoembolization (TACE) on liver tumors, data have appeared on immediate and delayed complications, which, however, represent a description of clinical observations or literature reviews compiled on their basis. There are currently no systematic studies that study the timing of complications and risk factors.Aims: to evaluate immediate and delayed complications of transarterial chemoembolization with drug-saturable microspheres in the treatment of unresectable malignant liver tumors.Materials and methods: A retrospective observational uncontrolled study that included 75 patients with unresectable liver disease (65 patients with metastases, 10 patients with primary malignant tumors) who underwent 102 transarterial chemoembolizations with drug-saturable microspheres. The antitumor effect of TACE was assessed according to abdominal computed tomography (CT) and magnetic resonance imaging of the hepatobiliary zone (MRI) with intravenous contrast, performed within a limited time frame: no later than 2 weeks before (control 0), after 89 weeks (control 1) and 1617 weeks after TACE (control 2). In the event of complications, diagnostic studies were performed as clinically necessary.Results: 3 patients developed lesions of the biliary tree. The process began on days 211 after TACE with dilatation of the bile ducts in single segments; changes in 23 weeks took on a bilobar character, leading to the formation of bilomas (2 patients) and necrosis of the periductal liver parenchyma (1 patient). Before TACE, all three patients underwent bile duct stenting due to existing biliary hypertension. Two patients developed pancreatitis 12 weeks after TACE; at the same time, there were no features of vascular anatomy, non-target embolization. In 17 patients after 2-4 months after TACE according to CT and MRI, the phenomena of cholecystitis were noted. The changes were asymptomatic, leading to the formation of small stones in the gallbladder lumen after 610 months.Conclusions: The immediate complications of TACE with drug-saturated microspheres (1-3%) in the treatment of unresectable liver tumors are associated with the pathology of the bile ducts and pancreas, appear in the first month, have a staging, affect the somatic condition of patients and require specific treatment. Long-term complications (23%) are associated with the reaction of the gallbladder, develop after a few months, while they are asymptomatic and do not require correction.
Method of Objective Assessment of Intestinal Viability Using “Smart Light” Polychrome LED Light Source for Contrast Imaging of Biological Tissues during Surgical Operations
Authors: Adamenkov Nikita Alekseevich , Kozlov Igor Olegovich , Palalov Alexander Alexandrovich , Aladov Andrey Valmenovich , Chernyakov Anton Evgenievich , Potapova Elena Vladimirovna , Mamoshin Andrian Valerievich , Dunaev Andrey Valerievich
Published: December 2023

Introduction. Diseases accompanied by a violation of the blood supply to the intestinal wall occupy one of the main places in urgent surgery of the abdominal organs. Intraoperative assessment of intestinal viability is one of the most difficult tasks and plays a leading role in determining the volume of surgical aid, predicting the course of the postoperative period.Aim. To study the possibility of using contrast imaging using a controlled polychrome LED light source to assess the viability of the intestinal wall of a model animal in conditions of acute ischemia.Materials and methods. The work is based on the results of experimental studies conducted on 15 clinically healthy sexually mature laboratory rats. The simulation of acute small intestine ischemia lasting from 15 minutes to 12 hours was performed by ligation of the major vessels. Each animal underwent a relaparotomy after a corresponding time interval. The intestine was extracted from the abdominal cavity and visual parameters of wall necrosis were assessed using the Kerte method and using a polychrome LED light source for contrast imaging of biological tissues during surgery. After determining the visual signs of necrosis, intestinal fragments were submitted for pathomorphologic examination. The study was ended by removing the animal from the experiment according to the protocol approved by the Ethics Committee.Results. The spectral composition of the light source providing the most reliable detection of necrosis of the intestinal wall is represented by two spectral bands with maximum wavelengths of peak = 503 nm, peak = 594 nm and an approximate ratio of band intensities of 2:1. By morphological study, the following intervals were found to be significant when simulating small intestinal ischemia in the experiment: 1 hour after ligation - time of onset of ischemia, 6 hours - time when ischemia is reversible, and 12 hours - time when small intestine necrosis is recorded. Conclusions. The use of a controlled shadowless semiconductor light source for contrast imaging of biological tissues during surgery in the selected mode improves the definition of visual parameters of intestinal viability.
A Clinical Case of an Extrapulmonary Form of Generalized Sarcoidosis
in the Surgical Practice
Authors: Ruchkin Dmitry Valerievich , Khamidov Magomed Magomedovich , Okonskaya Diana Evgenievna , Kovalerova Natalya Borisovna
Published: December 2023

The aim of the study was to present a clinical case of generalized sarcoidosis without involvement of the lungs and intrathoracic lymph nodes.Materials and methods. The literature and data of clinical observation, surgical treatment and results of autopsy of a patient with generalized sarcoidosis were analyzed.Results. In this study, the authors draw attention to the case of generalized sarcoidosis without lesions of the lungs and intrathoracic lymph nodes, accounting for 5% in the structure of morbidity. A clinical case of patient A., who was hospitalized in the surgical department of the Emergency Hospital, is presented. The patient was admitted with suspicion of urgent surgical pathology with extrapulmonary manifestations of the disease (polyserositis) and granulomatous lesions of the parietal and visceral peritoneum, extrapulmonary pleura typical of sarcoidosis, and peritonitis, progression and development of a rare clinical form of the disease, neurosarcoidosis, which amounts to as much as 10 % of all cases of this disease.Conclusions. The clinical case demonstrates specificity of this multisystemic disease and the need for a multidisciplinary approach to treatment and diagnosis, which may be challenging due to the absence of typical manifestations of this pathology, as in the presented clinical case. The authors share their experience to help medical professionals avoid diagnostic and tactical errors in the management of such patients, since they encountered a truly untypical and rare manifestation and complication of sarcoidosis in a patient, who was admitted not in a specialized therapeutic or pulmonological department, but in surgical department of a multidisciplinary hospital.
Difficulties in Diagnosing Volumetric Formations of the Spleen: an Example of a Clinical Case
Authors: Aralova Mariia Valerievna , Alimkina Yulia Nikolaevna , Chernyh Alexander  Vasilyevich , Ostroushko Anton Petrovich , Brezhneva Vladislava Sergeevna
Published: December 2023

Differential diagnosis of bulk splenic neoplasms, despite proper visualization in ultrasound, computed tomography and magnetic resonance imaging of the abdominal cavity, is challenging due to the lack of a unified classification, the extremely rare occurrence of some tumors and difficulty of preoperative morphological identification. The paper discusses a case of making an erroneous preoperative diagnosis in a spleen mass: the instrumental study findings determined the presence of multiple cysts. The latter among all the neoplasms of this organ are the most common and are represented by a variety of forms, subdivided by origin, histogenesis and content features. According to some classifications, cysts are classified as tumors or tumor-like diseases, other sources classify them as non-tumor formations of the spleen. It is not often possible to fully exclude the parasitic origin of the cyst before the morphological study of the removed organ. Surgeons of the Voronezh Regional Clinical Hospital No. 1 encountered this problem during the treatment of a 34-year-old patient with the spleen neoplasm. A diagnosis of lymphangioma was made based on surgical treatment and pathomorphological findings. The analysis of this clinical case demonstrates relevance of splenectomy both as a method of final diagnosis and as the final stage of treatment for benign tumors; it allows avoiding misdiagnosis in case of a malignant tumor.
EMPIRIC ANTIBIOTIC THERAPY OF ACUTE INFLAMMATORY PROCESSES OF THE FACE AND NECK IN CHILDREN AT THE OUTPATIENT STAGE, BASED ON THE RESULTS OF BACTERIOLOGICAL MONITORING OF THE DEPARTMENT OF MAXILLOFACIAL SURGERY.
Authors: Kharitonov Dmitriy Yu. , Korytina Irina V. , Nazareva Nonna A. , Agapova Margarita A.
Published: December 2023

Based on the analysis of bacteriological cultures of the wound discharge according to archival data of the case histories of patients with acute inflammatory processes of the face and neck on the basis of the Department of Maxillofacial Surgery of the Voronezh Regional Children's Clinical Hospital No. 2, data were obtained on microbiological pathogens and their sensitivity to various antibacterial drugs. Monitoring was carried out and the pathogen was classified in the main inflammatory processes of the face and neck in children from 1 to 15 years old. Based on the results obtained, we have developed and proposed schemes for empirical antibiotic therapy for use by pediatric dentists and pediatricians on an outpatient basis. The most relevant for outpatient applications are oral antibiotics with high bioavailability and efficacy against etiological pathogens.
INVESTIGATION OF THE ADHESIVE ABILITY OF ZINC-PHOSPHATE CEMENTS TO THE DENTIN OF THE TOOTH
Authors: Valynov Anton S. , Ivanina Angelina S.
Published: December 2023

Improving the reliability of fixing fixed orthopedic structures of dentures is an urgent issue at all times. Due to the increase in the variety of materials in the modern world, the choice for dentists has become even more difficult. Various types of fixing materials are used in the clinic, and their choice depends on the specifics of the clinical situation and the material of the structure from which it is made.

One of the types of cements are zinc-phosphate, which are used in practice for a long time and are characterized by sufficient adhesion strength. Representatives of this group have become less popular in the orthopedic dental clinic, since its properties are considered insufficiently satisfactory. Undoubtedly, any fixing material has both pros and cons. It is possible to get high-quality treatment with a dental prosthesis in the oral cavity if the fixing materials are correctly selected, the principles of preparation are observed and a high-quality adhesive protocol is performed.

The article describes a study of the adhesive ability of individual zinc-phosphate cements, which was carried out in laboratory conditions at the technical base of LLC "Tselit" Voronezh. 30 teeth of the chewing group were used, which were divided into groups according to the use of materials: "NeoDent" LLC Celit, "VISCIN" LLC Raduga-R, "Adhesor" SpofaDental (Czech Republic).

The strength of adhesion was studied using the method - shear test, which determines the strength of the connection of dentine tissue with zinc-phosphate cement.
XEROSTOMIA AS AN IDIOPATHIC SYMPTOM IN DENTISTRY
Authors: Belenova Irina A. , Kopbaeva Myra T. , Popova Olesya B. , Smazhko Olga A.
Published: December 2023

The article presents an overview of modern scientific literature on the problem of xerostomia and its etiopathogenetic connection with various general somatic diseases. To date, often the treatment of xerostomia is carried out as an independent disease, due to the failure to identify the underlying pathology. Often, ignorance of the causal relationship of various diseases, both somatic and psycho-emotional, leads to an incorrect diagnosis at a dental appointment and, as a result, an incorrect treatment plan, which leads to a deterioration in the patient's condition and the occurrence of complications. In this connection, the task of a modern dentist becomes urgent to establish the true cause of the pathology of the oral cavity and provide highly qualified treatment, according to the obtained diagnostic data.
A-PRF AS AN ALTERNATIVE TO ALVEOLAR AUGMENTATION
Authors: Ramazanov Ruslan T. , Redkov Daniil A. , Gasanov Nushuravan T. , Lis Ekaterina А.
Published: December 2023

A dentist-surgeon performs a large number of different surgical procedures. Despite the fact that in the 21st century, the level of dental care is high, the number of tooth extractions has not decreased. The main component of surgical work is the extraction of a tooth.

The article analyzes the clinical and radiological control of the process of socket regeneration using A-PRF technology, in addition, an assessment of the opinion of doctors on the use of this technique of hole preservation after removal was carried out.

In his practice, a dental surgeon often encounters complications after a tooth extraction operation, and in order to avoid them, it is necessary to carry out a set of measures aimed at improving the rehabilitation period, optimizing the reparative process and improving the results of surgical treatment.

Based on the results of our work, we found that this technique is not popular among doctors, although it shows good results. When using A-PRF clot, the period of socket epithelialization is reduced, and early formation of a bone pattern is observed, which we do not observe in patients in whom this technique is not used.

In order not to carry out repeated surgical reception in the future, it is necessary to think about early conservation.
EVALUATION OF THE EFFECTIVENESS OF PROFESSIONAL TRAINING OF PHARMACEUTICAL SPECIALISTS VORONEZH
Authors: Safonova Elena F. , Rudakova Lyudmila V. , Zheleznova Elena A. , Dyachenko-Kalyapina Yuliya O.
Published: December 2023

The data of domestic and foreign literature characterizing the current state of pharmaceutical education are studied. The criteria for the effectiveness of the process of professional development of pharmaceutical industry specialists have been established. A sociological study of pharmaceutical workers on the demand and quality of pharmaceutical education received by them was conducted. Practical recommendations aimed at improving the process of professional development of pharmaceutical workers to improve the quality of pharmaceutical care are proposed.
OBTAINING THE EXTRACT OF CHELIDONII MAJORIS L. AS A COMPONENT OF TOPICAL PREPARATIONS IN THE THERAPY OF PSORIASIS
Authors: Ryabinina Elena I. , Zotova Elena E. , Peleshenko Elena I. , Nasonova Ekaterina S.
Published: December 2023

Psoriasis is one of the most common dermatological diseases that significantly reduces the quality of life of patients. At the same time, about 70% of them need the use of external therapy. The aim of the study was to increase the degree of extraction of active substances from plant materials in order to improve the therapeutic properties of topical preparations for the treatment of psoriasis. For the treatment of psoriasis, it is necessary to use highly concentrated alkaloid extracts of celandine; for this, an 80% solution of acetic acid was used as an extractant.
DETERMINATION OF ANTIBIOTICS CEPHALOSPORIN SERIES WITH PIEZOELECTRIC SENSORS IN WATER SOLUTIONS
Authors: Petrova Olga K. , Ivanova Irina I. , Shapovalova Anna A. , Zyablov Aleksandr N.
Published: December 2023

The aim of the work was to create a piezoelectric sensor modified with a polymer with molecular imprints of cefuroxime for its subsequent determination in aqueous solutions. For the synthesis of MIP, we used a mixture containing a copolymer of 1,2,4,5-benzenetracarboxylic acid and 4,4'-diaminodiphenyl oxide produced by OJSC IIPP SPA Plastic (Moscow), as well as a solution containing template molecules.

The resulting mixture was applied to the surface of the sensor electrode by stamping. After that, thermal imidization was carried out in an oven. Next, the sensors were cooled and placed in distilled water to remove the template.

The resulting sensor was used to determine the content of the antibiotic cefuroxime in aqueous solutions using a calibration curve. For this, standard solutions of cefuroxime were prepared with concentrations of 1.0101 1.0107 g/dm3. The measurements made allowed us to conclude that with an increase in the antibiotic concentration in the analyzed solution, a decrease in the resonant frequency occurs. The calibration dependence is linear. The limit of detection of cefuroxime for the obtained sensor is 1.0105 g/dm3. To test the selectivity of the obtained sensor based on a polymer with molecular imprints, an analysis of an antibiotic similar in structure, cefazolin, was carried out. It has been established that the sensory system is selective only for the antibiotic that was used for the synthesis of MIP.
SELECTION OF A STRUCTURAL MATERIAL FOR THE BASIS OF A REMOVABLE PROSTHESIS IN PATIENTS WITH ORAL DYSBIOSIS BASED ON TOXICOLOGICAL EXAMINATION
Authors: Chirkova Natalia V. , Vecherkina Zhanna V. , Shalimova Natalia A. , Primacheva Natalia V.
Published: December 2023

It is proved that the tissues and organs of the oral cavity are normally in dynamic equilibrium with balanced biochemical processes that preserve tissue structures and support their function. The problem of the relationship of tissues and organs of the oral cavity with materials intended for the manufacture of dentures is one of the main problems in the clinic of orthopedic dentistry. Currently, acrylic plastics, the technological properties of which do not require expensive equipment, are most widely used in the manufacture of prosthetic structures. However, according to most experts, acrylic plastics have a number of significant drawbacks: the occurrence of toxic-allergic reactions, violation of the microflora of the oral cavity, the development of blastomatous growth in the tissues of the prosthetic bed. In order to increase the effectiveness of orthopedic treatment with removable dentures and reduce the intensity of the occurrence and development of oral dysbiosis and inflammatory reactions after prosthetics, the authors conducted biotesting of polymer materials of acrylic nature, the results of which are presented in this paper.
COMPARATIVE CHARACTERISTICS OF PREPARATIONS BASED ON ROSEHIP FRUITS
Authors: Zotova Elena E. , Ryabinina Elena I. , Livanova Алина F. , Salnikova Anastasia D.
Published: December 2023

The paper presents a comparative analysis of preparations based on rosehip fruits available on the Russian market in order to determine the effectiveness and expediency of choosing a drug. It is shown that the expediency of choosing a drug should first of all be determined by the purpose of use, despite the fact that all drugs, in addition to specific action, exhibit similar biological activity due to the content of vitamin C and other biologically active substances (BAS), which, depending on the variety of rosehip and the method of preparation of drugs, are still in them in different quantities. For the treatment of skin diseases, it is necessary to choose oils rich in PUFA and vitamin E. For the treatment of liver diseases, you should choose low-vitamin rosehip fruits or syrups based on it, which contain the largest amount of organic acids compared to other drugs. Among the natural preparations of the group of restorative and immunomodulatory effects, the most effective were rosehip fruits and water-soluble dry extract. In addition, it has been experimentally shown that all preparations from this group, except syrups, have adsorption activity against lead ions, which expands the list of useful properties of preparations based on rosehip fruits and increases the effectiveness of their use.
EXPERIENCE WITH COMBINATION THERAPY FOR PSORIASIS
Authors: Ryabinina Elena I. , Zotova Elena E. , Ryabinin Stanislav V. , Nasonova Ekaterina S.
Published: December 2023

Psoriasis is one of the most widespread dermatological diseases, having a strong influence on the quality of human life. About 70% of patients require external therapy at that. The aim of this work is evaluation of the efficiency of combination therapy of psoriatic patients by solidol in combination with application of greater celandine (Chelidonii majoris L.) extract. The areas of the skin, affected by psoriasis, were treated by celandine infusion 2 times a week during the first month of cure, and solidol was applied on plaque after drying. The same procedure was carried out in the second month once a week. The course of treatment was 2 months. The efficiency of described combination therapy was proved in a resulting keratolytic, antiphlogogenic, emollient and antipruritic action.