bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação da cobertura vacinal contra o papiloma vírus humano a partir da vacina HPV quadrivalente recombinante nos municípios 9º núcleo regional de saúde da Bahia
Authors: Manganelli Luciane Aparecida Gonçalves , Borges Grasiely Faccin , Fonseca Yago Soares , Santos Lhoren Batista , Ramalho Matheus Ramos
Published: May 2020

HPV (Papilomavírus Humano) é um vírus que pode ser transmitido sexualmente, possuindo mais de 100 tipos de vírus de DNA muitas vezes responsáveis pelo desenvolvimento de verrugas genitais, e nos casos mais severos, originando neoplasias como os cânceres de colo de útero, vagina, vulva e ânus. No Brasil a vacina quadrivalente que previne contra os tipos benignos de HPV 6 e 11 e contra os malignos 16 e 18 foi ofertada pelo SUS em 2014 para meninas de 9 a 13 anos de idade em três doses com intervalos de 0,6 e 60 meses. A vacina é preventiva e por isso necessita ampla cobertura para obter sucessona diminuição do índice dos portadores de HPV. Este trabalho objetiva avaliar índices de cobertura vacinal contra HPV nos municípios da área de atuação do 9º Núcleo Regional de Saúde da Bahia, tendo em vista a prevenção da infecção pelo HPV.
Análise do Desenvolvimento Socioeconômico em Campo Bom, Brasil, no contexto das cidades criativas
Authors: Raul de Souza Nunes  , Guerra ASHTON Mary Sandra , Dusan Schreiber
Published: May 2020

Campo Bom é cidade localizada no Rio Grande do Sul, Brasil que reflete o desenvolvimento econômico por meio do seu pioneirismo na produção e exportação de calçados, que é a principal atividade econômica da cidade há muitas décadas. Em relação ao seu desenvolvimento social a cidade promove ações que buscam o envolvimento da população com projetos culturais e atividades de literatura, teatro, festas e feiras populares. Esses fatores contribuem para elevar o Índice de Desenvolvimento Humano (IDH) de Campo Bom, para acima da média dos padrões brasileiros. Este trabalho tem o objetivo de analisar o desenvolvimento socioeconômico em Campo Bom, no contexto das cidades criativas, e observando a presença da diversidade cultural, sustentabilidade, inovação e inclusão. Em relação a metodologia, se fez uso do método exploratório descritivo com análise de conteúdo de cunho qualitativo. Foi realizada revisão bibliográfica, caracterização de Campo Bom, entrevistas com residentes e formadores de opinião, e por fim, foram aplicadas em Campo Bom as teorias de Reis (2011) e de Landry (2013) formuladas para as cidades criativas. Entre os resultados, vale ressaltar que a interpretação dos dados coletados facultou identificar que a vocação (tradição criativa) em Campo Bom tem suas bases no setor coureiro-calçadista como o mais relevante para o desenvolvimento socioeconômico municipal. Observou-se que as atividades vinculadas ao setor coureiro-calçadista é o responsável pelas dinâmicas socioeconômicas cotidianas de Campo Bom. A produção de calçados, iniciada ainda no século XIX, chegou a fazer de Campo Bom o município pioneiro na exportação de calçados no Brasil, o que mais empregou e envolveu toda a sociedade local e regional. Atualmente, as atividades ligadas as indústrias criativas, como os índices de educação e a valorização de ações culturais como a literatura, a música, a dança e o teatro contribuem para o desenvolvimento de Campo Bom, gerando maior diversificação na economia local e inserindo o município no contexto das cidades criativas, conforme desenvolvido por autores consagrados nessa temática. Além disso, a gastronomia e o turismo também contribuem com o desenvolvimento socioeconômico local, visto que, possui gastronomia regional diferenciada e espaços públicos destacados voltados aos interesses de residentes e de turistas como a praça (Largo Irmãos Vetter) que abriga os mais significativos eventos municipais; a ciclovia de 22 km de extensão que facilita a mobilidade dos cidadãos; o ambiente do Centro de Educação Integrada (CEI) com biblioteca, teatro, praça, entre outros.
Decolonizing Description: First Steps to Cataloguing with Indigenous Syllabics
Authors: Fagnan Luc
Published: May 2020

In light of the TRC Calls to Action from 2015 and the CFLA’s Truth & Reconciliation Report and Recommendations from 2017, many libraries in what is known as Canada have begun to take steps towards decolonization. Decolonizing bibliographic descriptions in library catalogues is an important part of this process, as this can impact both the ability to access Indigenous materials and the representation of Indigenous Peoples and Knowledges in the library.

While various efforts to work towards accurately and respectfully representing Indigenous Peoples and Knowledges in library catalogues are ongoing, the inclusion of Indigenous Syllabics in bibliographic records is one way in which cataloguers can begin to put these efforts into action. In addition to collaborating with Indigenous community members and Indigenous librarians on this work, there are a variety of resources and tools available online that can aid cataloguers in creating accurate and culturally appropriate descriptions of Indigenous materials. This extended abstract provides context and information that is central to this work, and gives a cursory overview of how one might insert Indigenous Syllabics into bibliographic records.
Küçük Radikal Tümlenmiş Modüller
Authors: ERYILMAZ Figen , TÜRKMEN Ergül
Published: May 2020

Bu çalışmada, küçük tümlenmiş modüller kullanılarak küçük radikal tümlenmiş modüller tanımlanmıştır ve bu modüllerin çeşitli özellikleri elde edilmiştir. Her küçük tümlenmiş modülün ve her zayıf radikal tümlenmiş modülün küçük radikal tümlenmiş modül olduğu açıktır. Bu önermelerin terslerinin doğru olmadığına dair örnekler verilmiştir. Küçük radikal tümlenmiş modüllerin sınıfının sonlu toplamlarda ve bölüm modüllerinde korunduğu ispatlanmıştır. Bunun yanı sıra, sol kalıtsal halka üzerindeki bir M modülünün N⊆M olacak şekilde N küçük modülü için M nin küçük radikal tümlenmiş olması için gerek ve yeter koşulun M/N bölüm modülünün küçük radikal tümlenmiş olması gerektiği gösterilmiştir. Ayrıca sol kalıtsal R halkası için R sol R-modülünün küçük radikal tümlenmiş olması için gerekli ve yeterli koşulun R/(Rad(R)) bölüm modülünün küçük tümlenmiş olması gerektiği gösterilmiştir. Ayrıca, lokal Dedekind bölgesi üzerinde her küçük radikal tümlenmiş modülün radikal tümlenmiş olduğu ispatlanmıştır.
1D Kuantum Telin Ortalama Enerjisi ve Öz Isısı
Authors: BABANLI Arif , SABYROV Vepa
Published: May 2020

Bu çalışmada InAs yarıiletken heteroyapıdan oluşan bir boyutlu kuantum telin Rashba spin-orbital etkileşimi ve tel eksenine dik yönde yönelmiş manyetik alan etkisinde elektronların ortalama enerjisi ve öz ısısı teorik olarak araştırıldı. Sistemin dağılım fonksiyonu hesaplandı. Kuantum tel sistemin ortalama enerjisi, öz ısısı sıcaklığa göre grafiği oluşturuldu ve manyetik alanın şiddetine göre değişimi incelendi. Buna göre kuantum telin elektronlarının ortalama enerjisi, sıcaklık artmakta ve belli bir sıcaklıktan sonra sabit bir değere yaklaşmaktadır. Manyetik alanın şiddetinin artması veya azalması ortalama enerjinin sıcaklığa göre sabit değerini değiştirmektedir. Kuantum teldeki elektronların öz ısısı düşük sıcaklıkta maksimum değere ulaşmakta ve artan sıcaklıkla birlikte sıfıra gitmektedir. Elektronların öz ısısı sıcaklığa göre manyetik alanın farklı değerlerinde farklı maksimum tepe noktaları vermektedir.
ANALISIS RASIO ARUS KAS UNTUK MENILAI KINERJA KEUANGAN PADA KOPERASI KARYAWAN ANGKASA PURA 1 “SELAPARANG” BANDARA INTERNASIONAL ZAINUDIN ABDUL MAJID
Authors: Lalu Jamhuri Hidayat  , I Nengah Arsana  , Ni Nyoman Yuliati
Published: May 2020

This research aim to to know cash flow statement performance and growth of KokapuraSelaparang pursuant to year cash flow statement 2014-2018. this descriptive Research type with quantitative approach. Technique data collecting the used Technique interview and documentation. Research object in the form of balance data, loss and profit report, cash flow statement and allocation of division of Net income and also common picture of co-operation in year 2014-2018.

Technique analyse data the used [is] cash flow ratio analysis which consist of Cash Flow Operation ratio ( AKO), Coverage Fund Flow ratio ( CAD), Coverage Cash ratio to Flower ( CKB), Coverage Cash ratio to Current Liabilities ( CKHL), Capital Expenditure ratio ( PM), Total Liabilities ratio ( TH), Free Clean Cash Flow ratio ( AKBB) and ratio Sufficiency of Cash Flow ( KAK).

Monetary performance of KokapuraSelaparang in year 2014-2018 assessed from cash flow statement ratio expressed is good enough, its performance [in] telling good enough because from eight calculation of cash flow ratio above expressing that 3ratio fulfill standard 1, and only 4 ratio which [is] menu [do] not standard 1. Ratio which [do] not fulfill standard namely Cash Flow Operation ratio ( AKO), Coverage Cash to Current Liabilities ( CKHL) and Total Liabilities ( TH) and Sufficiency Of Cash Flow ( KAK). And ratio which have fulfilled standard namely Coverage Fund Flow ( CAD), Coverage Cash to Flower ( CKB), Capital Expenditure ( PM), and Free Clean Cash Flow ( AKBB. In this case Co-Operation unable to pay [for] ability of fluent obligation and and also indigent provide cash to fulfill its obligation. KokapuraSelaparanghave to can improve cash flow of activit  operate for [so that/ to be] obligation short-range fufilled, maximizing and managing cash flow of got financing of member [so that/ to be] self-supporting.
PENGARUH PEMBERIAN PAKAN KULIT SAPI TERHADAP PERTUMBUHAN dan KELANGSUNGAN HIDUP BENIH LOBSTER PASIR (Panulirus homarus)
Authors: Tias Sherina aulia ningtias , Junaidi Muhammad , Rahman Ibadur
Published: May 2020

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kulit sapi terhap pertumbuhan dan kelangsungan hidup benih lobster pasir (panulirus homarus). Metode yang digunakan dalam penelitian itu yaitu metode experimental mengunakan rancangan acak kelompok (RAK), dengan 5 perlakuan yaitu pemberian 100% ikan rucah, 75% ikan rucah+25% kulit sapi, 50% ikan rucah + 50% kulit sapi, 25% ikan rucah + 75% kulit sapi dan 100% kulit sapi yang di ulang sebanyak 3 kali. pengamatan di lakukan selama 60 hari. parameter yang di amati meliputi pertumbuhan mutlak, laju pertumbuhan spesifik, rasio konversi pakan dan tingkat kelansungan hidup. Hasil penelitian menunjukkan bahwa pertumbuhan mutlak dan laju pertumbuhan spesifik tertinggi terdapat pada perakuan 3 (50% ikan rucah + 50% kulit sapi), yang dimana memberikan pengaruh yang berbeda nyata (P<0,05). Berdasarkan penelitian ini, untuk menggunakan pakan dengan 50% ikan rucah + 50% kulit sapi dan melakukan uji proksimat pada kulit sapi mentah dan rebus.
Sosialisasi Pembelajaran Berbasis Cara Kerja Otak dan Implikasinya dalam Pembelajaran di SD Kabupaten Lombok Timur
Authors: Handayani Baiq Sri , Idrus Agil Al , Lestari Nur , Artayasa Putu , Kusmiyati Kusmiyati
Published: May 2020

Abstrak: Guru sebagai penentu keberhasilan proses pembelajaran dirasa pelu untuk diberikan pemaham tentang kaitan antara ilmu neurosains dengan pembelajaran. Oleh karena itu Program Pengabdian Kepada Masyarakat Kemitraan dalam bentuk sosialisasi tentang pembelajaran berbasis cara kerja otak dan implikasinya dalam pembelajaran merupakan satu hal yang penting untuk dilakukan. Metode yang digunakan dalam pelaksanaan kegiatan ini yaitu ceramah interaktif atau diskusi informasi, dan tanya-jawab. Keberhasilan kegiatan sosialisasi dapat di ukur dengan melihat adanya peningkatan rata-rata skor pre test dan post test yang diperoleh peserta, nilai N-Gain. Selanjutnya data tersebut didukung oleh hasil quesioner tingkat kepuasan peserta terhadap pelaksanaan sosialisasi. Materi sosialisasinya meliputi: struktur otak dan fungsi setiap bagian otak dalam belajar (materi I), cara otak mengolah informasi (materi II), sistem pembelajaran alamiah otak (materi III), dan model-model pembelajaran berbasis cara kerja otak (materi IV). Peserta yang menjadi sasaran dalam kegiatan ini adalah guru-guru SD di Kabupaten Lombok Timur-NTB, berjumlah 50 orang (masing-masing kecamatan diwakili 5 orang guru). Kegiatan sosialiasi dilaksanakan di Gedung Aula Dikbud Kabupaten Lombok Timur-NTB, yakni pada tanggal 18 Juli 2019. Hasil kegiatan menunjukkan terdapat peningkatan pemahaman peserta dari pre tes ke posttes sebesar 0,59 pada materi I (kategori sedang), 0,65 pada Materi II (kategori sedang), 0,67 pada materi III (kategori sedang) dan 0,75 pada materi IV (kategori tinggi). Selain itu juga tingkat kepuasan peserta terhadap pelaksanaan kegiatan sosialisasi  rata-rata berkategori baik.
PEMBERDAYAAN KELUARGA MELALUI USAHA EKONOMI MIKRO
Authors: Hakim Fatwa Nurul
Published: May 2020

This research aims to know about Kreasindo handicraft activities in the village ofTamantirto Village, Kasihan Subdistrict – Bantul, Yogyakarta, Indonesia. Bantul whichproduces bags and shirts that are mostly done by rural women, how much results or wagesgained, and the utilization of income for families. The research was conducted using aqualitative descriptive method. Data collection techniques Observation and in-depthinterview were used for data collection and an interview of 18 craftsmen and entrepreneursas a craft manager. Of the 18 workers consisting of 15 female workers and 3 male workers.All come from the countryside with ELEMENTARY, JSS and high school backgrounds. For18 workers who have been families, their children have entered education at the elementaryschool so that after carrying out homework, they have free time that can be utilized to work.Income gained to improve family welfare. While 3 male workers earned income is onlyenough to be used to meet the basic needs of families. Nevertheless, the work activity ismaintained because it has no other job opportunities that can be used as a source of income.As for women workers in filling their free time want to work to increase family income.
Las utopías del bienestar general: De la idea de ciudad de Thomas Moro a Yuval Harari
Authors: Muñoz Cardona Ángel Emilio , Quintero Núñez Helmer
Published: May 2020

El fin último de las utopías es el ideario reflexivo de un mundo mejor; más solidario y menos egoísta. Es la búsqueda incesante de un orden social abierto a la simpatía moral, un lugar donde no prevalece la explotación del hombre por el hombre. El objetivo del presente ensayo de investigación es mostrar cuál es la relación y cuáles son los aportes sociales que subyacen en los planteamientos éticos de Thomas More, Tommaso Campanella, Paul Lafargue, Aldous Huxley y Yuval Noah Harari, en el debate contemporáneo de las administraciones de ciudad. Siguiendo un análisis cronológico, lógico-deductivo, el ensayo concluye que no hay una utopía que sea utópica. Existen nuevos esfuerzos sociales, tal vez utópicos pero no imposibles, que buscan construir una ética pública en el diseño de ciudades del aprendizaje, del conocimiento y de la innovación.
Guardia Campesina del Catatumbo, (Asociación Campesina del Catatumbo ASCAMCAT). Entre la autoprotección, el empoderamiento y la construcción territorial.
Authors: Alba Maldonado José Manuel , Santiago Velásquez Javier Alonso , Jácome Garzón Edidvanidt
Published: May 2020

El presente artículo es resultado de un trabajo de investigación social, centrado en identificar cómo a partir de procesos de autoprotección como la Guardia Campesina del Catatumbo de la Asociación Campesina del Catatumbo (ASCAMCAT), se han generado procesos de empoderamiento y construcción del territorio. El diseño metodológico se desarrolla dentro de un paradigma cualitativo y enfoque histórico hermenéutico, usando herramientas de recolección de información como la observación directa, estudios de caso, historia de vida, reconstrucción de memoria histórica. Entre los principales resultados se puede mencionar que la Guardia Campesina surge como una acción de autoprotección debido a la vulnerabilidad que presentan las comunidades rurales en la región del Catatumbo, generando empoderamiento del territorio y procesos de construcción territorial.
Antidiarrhoeal activity of ethanolic stem bark extract of Newbouldia laevis in castor oil-induced diarrhoea in rats
Authors: Aderinola AA , Ejiofor J , Oyinloye OE , Fasanya TA , Eremu E
Published: May 2020

Background: Diarrhoeal disease is the second leading cause of morbidity and mortality in developing countries requiring urgent attention. Many of the conventional anti-diarrhoeal drugs cause serious adverse effects, hence the need to screen various plants for their medicinal values becomes imperative.
Objective: To investigate the anti-diarrhoeal activity of ethanolic stem bark extract of Newbouldia laevis in castor-oil induced diarrhoea in rats.
Methods: The stem bark of Newbouldia laevis collected from Abeokuta, Ogun State, was air-dried, ground, macerated in 90% ethanol and concentrated to dryness in a water bath and then reconstituted using distilled water. Fifty (50) albino rats of both sexes used for the study were divided into two groups: A and B with twenty-five (25) rats per group.
Group A was used for the gastro-intestinal motility test using charcoal meal while
Group B was used for castor-oil induced diarrhoea test and the number of stool pellets was counted over an hour period.
Results: The extract (250-1000mg/kg) showed significant (p = 0.0399) anti-diarrhoeal activity by decreasing the distance of the gastrointestinal movement of charcoal meal in the treated rats and also inhibited the severity of diarrhoea induced by castor-oil in a dose-dependent manner when compared with the control (distilled water). This activity could be attributed to phytochemicals like flavonoids and tannins present in Newbouldia laevis.
Conclusion: The results showed that stem bark extract of Newbouldia laevis possesses a significant anti-diarrhoeal property and this supports the traditional use of the plant in the treatment of diarrhoea.
Research on the Way to Promote the Innovation of Ideological and Political Teaching in Colleges and Universities with the “Emotion, Reason and Taste” of Red Culture
Authors: Li Yue
Published: May 2020

As an important part of the advanced socialist culture, red culture has profound inner spiritual connotation and abundant external forms of expression, which provides good educational resources for the innovation of ideological and political courses in colleges and universities in the aspects of “emotion, reason and taste”. As a result, digging the ideological and political education value of red culture from multiple perspectives, actively employing all means and opening up various ways to promote the deep integration of red culture & ideological and political teaching activities has become a significant measure to promote the innovation of ideological and political teaching in colleges and universities.
PENGADOPSIAN UNCAC MENGENAI PENGEMBALIAN ASET HASIL KORUPSI YANG DIBAWA ATAU DISIMPAN KE LUAR NEGERI DALAM PENEGAKAN HUKUM INDONESIA
Authors: Latukau Fikry
Published: May 2020

Korupsi merupakan permasalahan universal yang dihadapi oleh seluruh negara dan masalah pelik yang sulit untuk diberantas, hal ini tidak lain karena masalah korupsi bukan hanya berkaitan dengan permasalahan ekonomi semata, melainkan juga terkait dengan permasalahan politik, kekuasaan dan penegakkan hukum. salah satunya dalam penegakkan hukum tindak pidana korupsi yang hasil dari korupsinya dibawa ke luar negeri, pengembalian aset hasil korupsi ini sangat  penting mengingat mengembalikan hasil dari korupsi  adalah tujuan utama dalam meberantas tindak pidana korupsi tersebut. Penulisan ini menggunakan metode penelitian hukum normatif, karena penulis tidak melakukan studi lapangan.
Nosema ceranae ile doğal enfekte balarısı kolonilerinde NOSEBA®’nın etkinliğinin araştırılması
Authors: ÖZÜİÇLİ Mehmet , AYDIN Levent , GİRİŞGİN A. Onur , SAYGIN Betül , ÇİMENLİKAYA Nurgül , ALTAV Yiğit , ZENGİN Suna Aslı
Published: May 2020

Bu
çalışmada, Arion İlaç Ar-Ge Merkezi ve Bavet İlaç San. ve Tic. A.Ş. tarafından
geliştirilen esansiyel yağ karışımı ile vitamin bileşiklerinin (Noseba®),
Nosema ceranae ile doğal enfekte
balarısı kolonilerinde etkinliğinin araştırılması amaçlanmıştır. Çalışma
süresince kullanılan kolonilerde sadece N.
ceranae bulunduğu, PCR ile daha önceki bir çalışmada saptanmıştır. Bursa
yöresi İkizce köyünde Mayıs 2019’da 10’ar çerçeveli kolonilerden digestion
yönteminde pozitiflik/negatiflik kontrolü için kovan başı en dış çerçeveden 25’er
arı muayene edilip,  pozitif çıkan kolonilerden
Neubauer lamına alınarak ışık mikroskobunda 40x10 büyütmede sayılıp Shimanuki-Knox
formülü ile arı başına düşen spor sayısı tespit edilmiştir. Pozitif kovanlar
spor sayıları dikkate alınarak 7’şerli 4 gruba ayrılmış, toplam 28 kovan çalışmada
kullanılmıştır. Üç ayrı deneme grubunda 1 lt 1:1’lik şeker şurubuna sırasıyla
20, 40 ve 80 cc Noseba® karıştırılmış, Nosema-pozitif bir adet
kontrol grubu ise deneme sonuna kadar tedavi edilmeden bırakılmıştır.

Nosema
sayımını takiben 2 gün üst üste 0,5 lt Noseba® karışımları tedavi
gruplarındaki kolonilere oral yolla verilmiştir. Tedavi sonrası  +1, +5, +10 ve +15. günlerde tekrar spor sayımı
yapılmış, kontrol grubu ile istatistiki olarak karşılaştırılmıştır. Sonuç
olarak kontrol grubu ile karşılaştırıldığında sırası ile 1. tedavi grubu %34,2;
2. tedavi grubu %67,2 ve 3. tedavi grubu % 99,9 etkili bulunmuş, kontrol grubu
çalışma sonunda 3. tedavi grubu (80 cc) ile tedavi edilmiş ve %99,9’luk
etkinlik saptanmıştır. Çalışma süresince Noseba®’dan kaynaklı hiçbir
yan etki ve koloni kaybı görülmemiştir.
Wiederbelebung einer unscheinbaren Position
Authors: Vogel Martin
Published: May 2020

Der Abbau von Hierarchie und die Demokratisierung von Organisationen sind gegenwärtig zentrale Konzepte in Veränderungsprojekten. Neue Organisationsformen bringen neue Rollenkonzepte hervor, andere verschwinden völlig, so zum Beispiel die klassische Position des Stellvertreters. Selbstorganisierte Teams führen sich selbst und vertreten sich auch selbst. Umso bemerkenswerter ist es, wenn dennoch der Wunsch nach stellvertretenden Führungspositionen auftaucht. So geschehen in einer Kommunalverwaltung einer deutschen Großstadt. Gezeigt werden zentrale Erkenntnisse einer Begleitforschung, bei der die Wiedereinführung von Stellvertretungen beobachtet wurde. Bezogen auf die Idee der Demokratisierung durch Hierarchieabbau in Organisationen kommt der Artikel zu einem paradoxen Fazit.
Синтез и цитотоксическая активность N-гликозидов индоло[2,3-a]пирроло[3,4-c]карбазол-5,7-дионов, замещенных по малеимидному атому азота
Authors: Эктова Лидия Владимировна , Еремина Вера Александровна , Тихонова Надежда Ивановна , Плихтяк Ирина Леонидовна , Медведева Лидия Александровна , Ярцева Ирина Вячеславовна , Моисеева Наталья Ивановна , Голубева Ирина Сергеевна , Яворская Надежда Петровна , Будько Андрей Павлович , Тарасова Ольга Ивановна , Пугачева Ружена Борисовна
Published: May 2020

Взаимодействием N-гликозидов индоло[2,3-a]фурано[3,4-c]карбазол-5,7-дионов с гидразингидратом, гидрохлоридом гидроксиламина, формилгидразином получены соответствующие N-6 замещенные гликозиды индолопирролокарбазолов. В качестве углеводных остатков использованы L-арабиноза, D-галактоза, D-ксилоза и D-рибоза. Полученные соединения изучены in vitro и in vivo. Они показали значительную антипролиферативную активность на клетках HCT-116 (IC50 10–6 – 10–7 М) и высокий противоопухолевый эффект на асцитных моделях опухоли Эрлиха и лимфолезкозе Р-388. Увеличение продолжительности жизни животных на первой модели составило от 540 – 495 % до 172 – 132 % и от 80 – 83 % до 120 – 93 % на второй модели.
Дипептидный миметик мозгового нейротрофического фактора ГСБ-106 предотвращает развитие ангедонии в условиях острого социального стрессаНИИ В УСЛОВИЯХ ОСТРОГО СОЦИАЛЬНОГО СТРЕССА
Authors: Таллерова Анна Вадимовна , Межлумян Армен Гарикович , Поварнина Полина Юрьевна , Антипова Татьяна Алексеевна , Логвинов Илья Олегович , Гудашева Татьяна Александровна , Середенин Сергей Борисович
Published: May 2020

При моделировании острого социального стресса изучено влияние димерного дипептидного миметика мозгового нейротрофического фактора гексаметилендиамида бис(N-моносукцинил-L-серил-L-лизина) (ГСБ-106, лекарственная форма) при пероральном 3-дневном введении в дозе 0,1 мг/кг на предпочтение 1 % раствора сахара и уровень белка постсинаптической плотности PSD-95 в префронтальной коре и гиппокампе мышей С57Bl/6. У стрессированных мышей статистически значимо снижалось потребление сладкого раствора и вдвое уменьшалось содержание PSD-95 в префронтальной коре по сравнению с контрольными животными. В гиппокампе изменений содержания PSD-95 у стрессированных животных не выявлено. Введение ГСБ-106 в дозе 0,1 мг/кг перорально в течение 3 дней однократно после каждой сессии стресса полностью предотвращало развитие ангедонии по показателям потребления раствора сахара. Влияния ГСБ-106 на сниженное содержание PSD-95 в префронтальной коре стрессированных животных в период эксперимента не выявлено.
Антипролиферативная активность N-замещенных 2,4-диамино-5-арил-5,6,7,8,9,10-гексагидробензо[b][1,8]-нафтиридин-3-карбонитрилов
Authors: Бардасов Иван Николаевич , Алексеева Анастасия Юрьевна , Ершов Олег Вячеславович , Марьясов Максим Андреевич
Published: May 2020

Исследована антипролиферативная активность N-замещенных 2,4-диамино-5-арил-5,6,7,8,9,10-гексагидробензо[b][1,8]нафтиридин-3-карбонитрилов. На активность веществ оказывают значительное влияние заместители в положениях 5 и 7 нафтиридинового кольца и незначительное — в положении 1. Так соединения с 3,4,5-триметоксифенильным радикалом при C-5 атоме значительно превосходят остальные производные. Влияние других заместителей не установлено, однако заместитель при C-7 атоме играет ключевую роль в проявлении биологической активности.
Оптимизация состава и технологии получения таблеток с фукоиданом и их биофармацевтическая оценка
Authors: Облучинская Екатерина Дмитриевна , Пожарицкая Ольга Николаевна , Флисюк Елена Владимировна , Шиков Александр Николаевич
Published: May 2020

Поиск и разработка лекарственных средств, способных конкурировать по эффективности с прямыми антикоагулянтами, является актуальной задачей. Фукоидан — сложный разветвленный гетерополисахарид с антикоагулянтной и антитромбической активностью. Субстанция фукоидана гигроскопична и обладает неудовлетворительными технологическими свойствами. Цель исследования — разработка оптимального состава и технологии таблеток с фукоиданом, а также их биофармацевтическая оценка. Для оптимизации состава лекарственной формы применен метод обобщённой функции желательности Харрингтона, дисперсионный и регрессионный анализы. Наибольшее влияние на распадаемость и прессуемость модельных таблеток оказывали содержание кросповидона и лактозы. Содержание лактозы оказывало значимое влияние на индексы Карра и Хауснера. Проведен сравнительный анализ кривых растворения таблеток in vitro (pH 1,2; 5,7; 6,8). Высвобождение фукоидана in vitro из разработанных таблеток описывается уравнением кинетики первого порядка.
Экономически обоснованные технологические карты возделывания зерновых колосовых на основе адаптивных технологий, используемых в Калужском регионе
Authors: Кузнецова Любовь Васильевна
Published: May 2020

Впервые в условиях Калужской области рассчитаны экономически обоснованные технологические карты возделывания зерновых колосовых культур на основе адаптивных технологий, использования новейших районированных сортов, высокопроизводительных механизированных агрегатов, а также адаптированной системы применения минеральных удобрений и защиты растений, которые позволят производить продукцию, конкурентоспособную на внутреннем и внешнем продовольственных рынках. Расчет типовых технологических карт по выращиванию зерновых колосовых культур дает основание утверждать, что на производство 1 ц озимых зерновых колосовых культур при плановой урожайности 45 ц/га потребуется 843,6 руб. и 95,6 нормо-смен, из которых 72,5 — нормо-смен трактористов-машинистов. На производство 1 ц яровых зерновых колосовых культур при плановой урожайности 40 ц/га потребуется 802,4 руб. и 90,1 нормо-смен, из которых 68,7 — нормо-смен трактористов-машинистов. На основе полученных показателей эффективности производства с учетом погодного риска и конъюнктуры рынка можно утверждать, что экономическая эффективность сельскохозяйственных культур (уровень рентабельности) варьирует в зависимости от ценового предложения: по озимым зерновым колосовым — от –0,08 до 26,3 %; по яровым зерновым колосовым культурам — от –0,8 до 21,5 %. Применение результатов исследования рекомендовано в сельскохозяйственных организациях и фермерских хозяйствах Калужской области.
Разработка наноразмерных лекарственных форм этопозида и исследование их противоопухолевой активности in vitro
Authors: Merkulova M. , Ostrovskiy К. , Osipova N. , Moiseeva N. , Maksimenko O. , Gelperina S. , Menshutina N.
Published: May 2020

Разработан метод получения водорастворимых форм этопозида солюбилизацией его человеческим сывороточным альбумином или растворимым производным витамина Е (TPGS). Полученные формы представляют собой субмикронные суспензии с содержанием этопозида не менее 1 мг/мл: размер частиц составляет ~150 нм (в случае альбумина) и ~15 нм (в случае TPGS). Полученные формы устойчивы при лиофилизации и не содержат органических растворителей. Обе формы показали более высокую по сравнению с препаратом Этопозид-Тева цитотоксичность in vitro в отношении линии клеток опухоли молочной железы MCF-7.
The Sensitivity of Teacher Value-Added Scores to the Use of Fall or Spring Test Scores
Authors: Atteberry Allison , Mangan Daniel
Published: May 2020

Papay (2011) noticed that teacher value-added measures (VAMs) from a statistical model using the most common pre/post testing timeframe–current-year spring relative to previous spring (SS)–are essentially unrelated to those same teachers’ VAMs when instead using next-fall relative to current-fall (FF). This is concerning since this choice–made solely as an artifact of the timing of statewide testing–produces an entirely different ranking of teachers’ effectiveness. Since subsequent studies (grades K/1) have not replicated these findings, we revisit and extend Papay’s analyses in another Grade 3–8 setting. We find similarly low correlations (.13–.15) that persist across value-added specifications. We delineate and apply a literature-based framework for considering the role of summer learning loss in producing these low correlations.
A Matter of Measurement: How Different Ways of Measuring Racial Gaps in School Discipline Can Yield Drastically Different Conclusions About Racial Disparities in Discipline
Authors: Curran F. Chris
Published: May 2020

Racial disparities in school discipline remain central to policy discussions around school discipline. Recent research points to the importance of how discipline disparities are measured for the conclusions that are drawn about the extent of the problem or whether such disparities are improving. This brief uses data from Maryland to demonstrate how the choice of metric of the Black-White discipline gap can drastically change conclusions about whether the gap is closing or widening as well as conclusions about whether particular districts or schools have high or low racial disparities in discipline. This brief shows how interpretations of the Black-White discipline gap can be drastically different when using different metrics. Implications for educational researchers and practitioners studying school discipline are given.
On Plurality Voting and Runoff Elections: Information Aggregation under Divided Majority
Authors: Gao Jacque
Published: May 2020

This article compares Plurality Voting (PV) and two forms of Runoff Elections (RE) in a setting in which (i) there are two majority-preferred alternatives, (ii) a strong minority backs a third alternative which would make the majority strictly worse off, and (iii) some of the majority voters are uninformed about the "correct" majority alternative. I show that in the informative equilibrium in Majority Runoff Elections (MRE), uninformed majority voters vote randomly with strictly positive probability, achieving partial information aggregation, while they always abstain in Automatic Runoff Elections (ARE), achieving full information aggregation and strictly improving the majority's welfare. However, uninformed majority voters do not abstain in PV, resulting in less information aggregation than in both MRE and ARE.
Narrative Style of Time of Habiburrahman El Shirazy in Building the Bidadari Bermata Bening Novel
Authors: Noermanzah  , Syafryadin  , Sari Ira Komala , Juwati  , Martina Feny
Published: May 2020

This study aims to describe the narrative style of time of Habiburrahman El Shirazy's in developing the Bidadari Bermata Bening novel. The research method used is the narrative method. Data collection techniques using documentation techniques. Data analysis techniques with steps: compiling a series of events in the novel, determining the time of events in the novel and the actual time of events, and determining the type of time contained in the novel. Test the validity of the data using member checking, bending, and validation of literary experts. The results showed that the narrative style of time by Habiburrahman El Shirazy in constructing the Bidadari Bermata Bening novel consists of: (1) the actual duration of the story is 59 years starting from the introduction of Ayna's parents, until Ayna lived happily in Amman with her husband, Afif. (2) Order of the story in the novel's text is a 10-year story of the event starting from the atmosphere of Ayna in Kanzul Ulum Islamic Boarding School, Magelang, Ayna who was still in high school class, then made a flashback or flashback, namely telling the present and past when the death event Ayna's parents, and the Ayna parents meeting in Jordan, then the story ends with Ayna's happiness in Amman with her husband, Afif. Then, (3) frequency in the form of repetitive frequency is more dominant followed by singular, multiple-singular, and iterative frequencies. While the events that often arise are the events of Ayna's adolescence, namely the story of Ayna who received the National Examination score, Ayna who could not watch the Wayang Kulit performance, the love story of Ayna and Afif, the event of Ayna's adult life which is the story of Ayna's life with Yoyok, the difficulties of Ayna's life after getting divorced from Yoyok, and Ayna's success.
Potential Use of Pomalaa Nickel Slag as A Substitute for Sand in Brick Making
Authors: Ngii Edward
Published: May 2020

The latest variance of nickel slag from PT.Antam Pomalaa hasmaterial gradation size equivalent to sand has, so it has potentially as a sandsubstitute material. The study aims to determine the use of fine nickel slag asa substitute for sand in brick making. Nickel slag used is variation of 0%,25%, 50%, 75% and 100% against of total weight of sand. The brick isdesigned with a cement – sand ratio of 1 : 7. The experimental is a hollow brickwith dimension of 40 cm×18 cm×10 cm. Compressive test is done after brickcuring along 28 days. The maximum result of compressive test is obtained inthe use of 50 % nickel slag of 19.58 kg/cm2 compared to the brick withoutnickel slag of 12.92 kg/cm2. The conclusion that by using a fine nickel slagtype of fenil iv up to 50 % on production, it can reduce sand use and improvethe strength up to 51%.
Evidence that instrumental conditioning requires conscious awareness in humans
Authors: Skora Lina , Yeomans Martin Richard , Crombag Hans C. , Scott Ryan Bradley
Published: May 2020

Instrumental conditioning is a crucial substrate of adaptive behaviour, allowing individuals to selectively interact with the stimuli in their environment to maximise benefit and minimise harm. The extent to which complex forms of learning, such as instrumental conditioning, are possible without conscious awareness is a topic of considerable importance and ongoing debate. In light of recent theoretical and empirical contributions casting doubt on the early demonstrations of unconscious instrumental conditioning, we revisit the question of its feasibility in two modes of conditioning. In Experiment 1, we used trace conditioning, following a prominent paradigm (Pessiglione et al., 2008) and enhancing its sensitivity. Success in this task requires participants to learn to approach reward-predictive stimuli and avoid punishment-predictive stimuli through monetary reinforcement. All stimuli were rendered unconscious using forward-backward masking. In Experiment 2, we used delay conditioning to shorten the stimulus-outcome delay, retaining the structure of the original task but presenting the stimuli under continuous flash suppression to allow for an overlap of the stimulus, action, and outcome, as well as replacing monetary reinforcement with primary appetitive reinforcement. In both experiments, we found evidence for absence of unconscious instrumental conditioning, showing that participants were unable to learn to adjust their behaviour to approach positive stimuli and avoid negative ones. This result is consistent with evidence that unconscious stimuli fail to bring about long-term behavioural adaptations, and provides empirical evidence to support theoretical proposals that consciousness might be necessary for adaptive behaviour, where selective action is required.
Marriage and Divorce
Authors: Pragholapati Andria
Published: May 2020

In-Law No. 1 of 1974 in article 1, marriage is an inner and outer bond between a man and awoman as husband and wife with the aim of forming a happy and eternal family (household)based on the Godhead of the Almighty. The law does not specifically explain the meaning ofdivorce. In the Big Indonesian Dictionary, Divorce comes from the syllable of divorce, anddivorce according to language means separation, concerning divorce between husband and wife,division, divorce.
The Impact of the Great Recession on Mothers’ Employment
Authors: Landivar Liana Christin
Published: May 2020

In all recent recessions, men’s unemployment has been higher than women’s because they are disproportionately likely to be concentrated in cyclical industries such as construction and manufacturing. This recession has been particularly severe for men and women, as they are both experiencing unprecedented levels of long-term unemployment, along with declining wages. Because of the severity of the recession, married mothers of young children may have increased their labor force participation to compensate for their husbands’ under- or unemployment. Using 2006 and 2010 American Community Survey data, I show that married mothers’ increased labor force participation likely occurred in households that were less economically disadvantaged prior to the recession. The demand for married women’s employment should have been stronger in households where men were employed in industries that were hard-hit by the recession. However, employment rates were lower among women married to men with lower earnings who are or were employed in construction and agriculture, the two industries with the highest levels of unemployment. Because their wives were less likely to be employed prior to the start of the recession, they may have been at a stronger disadvantage in obtaining employment in a tight labor market without recent job experience.
The French public’s attitudes to a future COVID-19 vaccine: the politicization of a public health issue
Authors: Ward Jeremy Keith , Alleaume Caroline , Peretti-Watel Patrick
Published: May 2020

As Covid-19 spreads across the world, governments turn a hopeful eye towards research and development of a vaccine against this new disease. But it is one thing to make a vaccine available, and it is quite another to convince the public to take the shot, as the precedent of the 2009 H1N1 flu illustrated. In this paper, we present the results of four online surveys conducted in April 2020 in representative samples of the French population 18 years of age and over (N=5,018). These surveys were conducted during a period when the French population was on lockdown and the daily number of deaths attributed to the virus reached its peak. We found that if a vaccine against the new coronavirus became available, almost a quarter of respondents would not use it. We also found that attitudes to this vaccine were correlated significantly with political partisanship and engagement with the political system. Attitudes towards this future vaccine did not follow the traditional mapping of political attitudes along a Left-Right axis but oppose people who feel close to governing parties (Centre, Left and Right) on the one hand, and, on the other, people who feel close to Far-Left and Far-Right parties as well as people who do not feel close to any party. We draw on the French sociological literature on ordinary attitudes to politics to discuss our results as well as the cultural pathways via which political beliefs can affect perceptions of vaccines during the COVID-19 pandemic.
Does One Effect Size Fit All? The Case Against Default Effect Sizes for Sport and Exercise Science
Authors: Caldwell Aaron R , Vigotsky Andrew David
Published: May 2020

Recent discussions in the sport and exercise science community have focused on the appropriate use and reporting of effect sizes. Sport and exercise scientists often analyze repeated-measures data, from which mean differences are reported. To aid the interpretation of these data, standardized mean differences (SMD) are commonly reported as description of effect size. In this manuscript, we hope to alleviate some confusion. First, we provide a philosophical framework for conceptualizing SMDs; that is, by dichotomizing them into two groups: magnitude-based and signal-to-noise based SMDs. Second, we describe the statistical properties of SMDs and their implications. Finally, we provide high-level recommendations for how sport and exercise scientists can thoughtfully report raw effect sizes, SMDs, or other effect sizes for their own studies. This conceptual framework provides sport and exercise scientists with the background necessary to make and justify their choice of an SMD. The code to reproduce all analyses and figures within the manuscript can be found at the following link: https://www.doi.org/10.17605/OSF.IO/FC5XW.
Silsilah Keluarga Adib Rifqi Setiawan & Wahyu Eka Saputri (16 Generasi)
Authors: Setiawan Adib Rifqi
Published: May 2020

Silsilah Keluarga Adib Rifqi Setiawan & Wahyu Eka Saputri (16 Generasi)
Assessment Instrument of Financial Literacy for Fiqh Mu'āmalāt Learning Based on Kitab Kuning
Authors: Setiawan Adib Rifqi , Saputri Wahyu Eka
Published: May 2020

Nong Darol Mahmada said that fiqh is a collection of classical ulama's ijtihād results on al-Qur’ān and al-īadīts as the daily basis of Muslims in every context of life. Based on the direction, the fiqh map can be classified into 2 major groups: ibādāt and mu’āmalāt. The direction of the discussion of the ibādāt group is the relationship between humans and Allōh (ḥablun min Allōh), while mu'āmalāt is a group whose direction addresses the relationship between humans and something else (ḥablun min al-nas and ḥablun min al-‘ālam). The goal of this cross-sectional survey research was to find the validity and reliability of assessment instrument of financial literacy for fiqh mu'āmalāt learning based on kitab kuning. To reveal validity is assessed based on obtain judgement expert and reliability measured by internal consistency. It was gained that the validity is 7 items very feasible and 5 item quite feasible with reliability’s value is 0,763. This finding shows that assessment instrument can be used to analyze difficulties of students for designing a learning program to guide students in pondok pesantren on achieving financial literacy throught fiqh mu’āmalāt learning that is based on kitab kuning (classical book).
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Published: May 2020

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