bluuebunny/crossref_metadata_2025 huggingface dataset:
Bacterial cellulose/calcium alginate hydrogels in wound’s cicatricial process of diabetic foot implementation: case report
Authors: Da Silva Gabriela Arruda , Zanchin Elissandra Moreira , Da Silva Andressa Mendes , Bertanha Matheus , Junior Antonio Eduardo de Aquino , Carbinatto Fernanda Mansano , De Oliveira Barud Hélida Gomes , Barud Hernane da Silva
Published: August 2022

It is well known that Diabetes mellitus (DM) is classified as a metabolic disease and in consequence several dysfunctions are expected, such as difficulties in wound healing process. Objectives: Due to the excellent properties of the developed bacterial cellulose/alginate hydrogel (BC/ALG), this material was applied to treat a diabetic ulcer patient. Method: The treatment was carried out at the Ambulatory of Santa Casa de Misericordia de São Carlos, by applying the hydrogel twice a week during 30 days. Results: After the period of treatment, the wound showed 84% of closure reduction when compared to its initial size Conclusion: Bacterial cellulose/ alginate hydrogel presented a high potential for successful treatment of wound closure.
Register number: 89006118.2.0000.8148
The Linguistic Reanalysis and Reinterpretation of Qur’ānic Verse 37 of Sūrat al-Qiyāmah
Authors: Al-Balushi Rashid
Published: August 2022

Qur’ānic verses have always received new interpretations in light of new historical evidence or scientific discoveries. This paper argues for the thesis that Qur’ānic verses may also receive new interpretations in light of novel construal of their linguistic properties. It proposes new interpretations of verse 37 of sūrat al-Qiyāmah (Resurrection, 75:37) based on a reanalysis of its structure, which leads to re-identifying what was traditionally construed as a verb as an adjective. The paper presents the traditional (standard) interpretations of verse Q. 75:37 and provides three new interpretations. It then argues for the legitimacy of the new interpretations, based on evidence from the Qur’ān and sunnah.
The Current Condition of the Religious Sphere in Kazakhstan
Authors: Almasovich Azilkhanov Marat , Zhalgas Askhatuly
Published: August 2022

This article analyzes the current conditions and trends in the religious space of the Republic of Kazakhstan. It outlines the main challenges and threats in the religious sphere and evaluates the main tendencies. The article draws upon the state policy in the religious sphere as well as upon data gathered from sociological studies conducted in the territory of Kazakhstan. It also analyzes the normative and legal acts regulating the religious sphere of Kazakhstan. It studies the formation of state policy of secular Kazakhstan in the religious sphere, which has been shaped by three factors: the search for and determination of the national development strategy of the country; the challenges and threats of the modern globalizing world; and the rise of the processes of secularism in other states. The article attempts to analyze the results of sociological studies of recent years regarding the risks associated with the erosion of the secular foundations of the state, as well as the issues related to the self-identification of Kazakhstani citizens. In particular, the article provides comprehensive information on the confessional structure of Kazakhstan, as well as separate samples based on the results of sociological studies on religious issues carried out by government agencies.
Effect of the Passive Oxide Films Structure and Surface Temperature on the Rate of Anodic Dissolution of Chromium-Nickel and Titanium Alloys in Electrolytes for Their Electrochemical Machining. Part 2. Anodic Dissolution of Titanium Alloys in Nitrate and Chloride Solutions
Authors:   Shevchenko Pridnestrovie State University, Likrizon E. V. , Silkin S. A. ,   Kostroma State University, Russia, Dikusar A. I. ,   Institute of Applied Physics, Republic of Moldova
Published: August 2022

An experimental study of the anodic dissolution of titanium and its alloys, including pulsed dissolution (up to 100 A/cm2) under control of hydrodynamic conditions and surface temperature in nitrate and chloride solutions, showed that the process is carried out through the electrochemical formation of anodic oxide films (AOF) which can be chemically dissolved. An AOF has a bilayered structure, i.e. two barrier films on the interface with a metal and a solution. Its model is PDM-III (Point Defect Model). At certain conditions, it is possible to achieve a steady state in which the film growth rate is compensated by the rate of its chemical dissolution (observed at pulsed conditions). In this case, over 100% current efficiency based on the ionization of titanium in the oxidation state is achieved. During the conducted experiments, when treated with the direct current, the rate of the electrochemical formation of an AOF exceeded the rate of its chemical dissolution, which led to a decrease in to current efficiency which did not exceed 75%. An increase of the dissolution rate takes place with an increase in the electrolyte flow rate. Upon reaching the thermokinetic instability (TKI) of the AOF (thermal explosion due to a feedback rate of the electrochemical reaction-surface tem-perature-rate of an electrochemical reaction), the interaction of electrolyte components with the surface free of the film takes place, and, as a result, an “anomalous” anodic dissolution is observed with the current efficiency greater than 100%. Regardless the nature of the electrolyte, TKI is achieved at a current density of 1 A/cm2. It is shown that in nitrate solutions with certain parameters of pulsed processing (duty factor 2, dc 50%), the dissolution rate, and, in the case of electrochemical machining, the feed rate of a cathode-tool, can be more than twice higher than the rate of machining with the direct current of the same density.
The effect of the implementation of GCG principles and PSAK adoption of IFRS on quality of financial reports in SOEs
Authors: Sumiyati Sumiyati , Mappanyuki Ratna
Published: August 2022

The purpose of this paper is to study the effect of the implementation of GCG principles and PSAK adoption of IFRS on quality of financial reports in SOEs. The data for the study comes from questionnaires collected by the survey method. Smart PLS 3.0 is an analytical technique used in research, with 99 people as the data. The results indicate that the implementation of PSAK adoption of IFRS and GCG principles had a substantial favorable impact on financial report quality.
Board of directors and investment performance: A marginal Q approach
Authors: Gaitan Sandra , Saravia Jimmy , Tellez Diego
Published: August 2022

This paper aims to contribute to the debate on the effect of board characteristics on firm performance. We use marginal q to estimate the effect of board characteristics on investment performance. Using data of 1616 firms that traded on the Standard and Poor´s (S&P) 1500 between 1997 and 2014, we use between and fixed effects estimators to capture the long-run effects and control other endogeneity problems as omitted variable bias. We find a negative and statistically significant effect of board size on investment performance. For the sample under study, we also find empirical evidence on the nonlinear relation between board independence and investment performance. Finally, using two different measures, we also find a nonlinear relation between board busyness and investment performance.
Determinants of foreign direct investment in Southeast and South Asian countries
Authors: Yolanda Yolanda , Sumarni Sumarni , Kamil Muslim
Published: August 2022

The purpose of this study is to describe the Foreign Direct Investment (FDI) determinants of 6 countries, each of which is 3 countries from Southeast Asia and South Asia. Foreign Direct Investment (FDI) shows capital flows in 6 countries (Indonesia, Philippines, Malaysia, India, Pakistan and Bangladesh) that are affected by inflation, wage, Exchange Rate, Market Size and Trade Openness. The research method used is the regression of panel data for the period 2004-2019 from 6 countries in Southeast Asia obtained from the World Bank database. The results showed simultaneously and partially variable wage, exchange rate, market size and trade openness had a significant relationship with FDI inflows, except for variable inflation at α = 10%. Of the several variables studied, the dominant variable affecting the inflow of FDI in a country is the size of the market and followed by the wage level. In addition, of the 6 countries studied by countries that have great potential as recipients of FDI is Philippines.
Technological, organizational and environmental factors influencing on user intention towards big data technology adoption in Malaysian educational organization
Authors: Harun Noor Baizura , Jalil Habibah Ab , Zolkepli Maslina
Published: August 2022

Studying the factors in influencing the users’ intentions to adopt Big Data technology in Malaysia is crucial. This study adopted three grand theories which consisted of Dissemination of Innovation (DOI) theory, Technology Acceptance Model (TAM), and Technology-Organization Environment (TOE) framework. The model specifies technological, organizational, and environmental factors as determinants of the users’ intentions to adopt big data technology. This study aims to review the technology, organizational and environmental factors that can determine the intentions towards big data technology adoption. A total of 224 questionnaires were obtained and screened. Data was analyzed using the Partial Least Square Modelling of Structural Equations due to one of the best software for verifying structured data on structural equations modelling (SEM) Smart PLS 3.0 as analytical tools. This study finds that the predictor variables of compatibility, security are significant and critically direct to the users’ intentions to adopt big data technology. The results indicate that the model is suited for studying users’ intentions to adopt Big Data technology in educational organizations. This study can help the Malaysian ministry of education to emphasize the important factors in further developing the use of Big Data technology in organizations. The findings provide important recommendations and implications for BDA technology practitioners and application developers, which could coincide with successful BDA technology deployment. This study provides practitioners with practical recommendations for guidance in incorporating and endorsing BDA activities in their organizations in order to maximize the benefits of revolutionary technology, particularly in government agencies.
A study on the relationship between money supply and inflation in Vietnam from 2005 to 2021
Authors: Nguyen Van Anh Thi , Hoang Thanh Tung , Le Duc Anh
Published: August 2022

The study examines the relationship between money supply and inflation in Vietnam in the period of 2005-2021. The relationship between money supply and inflation is addressed in economic theories and models and has been studied by many experts in different economies in different periods. To examine the relationship between money supply and inflation in Vietnam in the period of 2005-2021, the research team collected data on money supply and inflation rate, then analyzed this relationship during three periods of 2005-2011, 2012-2019 and 2019-2021. Next, the research team collected data on money supply (MS - total means of payment) and consumer price index (CPI), quarterly data from the first quarter of 2005 to the fourth quarter of 2021 and uses Eviews 8 software for analyzing. The research team uses a linear regression model to evaluate the impact of money supply growth (GMS) on consumer price index (CPI), a variable representing the inflation rate, of Vietnam during the research period. The model results support the view that money supply growth and past inflation are among the factors affecting inflation in Vietnam. From the research results and the actual money supply, the money supply growth rate as well as the inflation rate in Vietnam during the research period, the research team makes some policy recommendations to achieve the targets of supporting economic recovery, controlling inflation, stabilizing the macro-economy in Vietnam after the Covid-19 pandemic.
Earnings management and managerial compensation in Nigerian manufacturing firms
Authors: Opudu Okubokeme Derek , Eze Gbalam Peter
Published: August 2022

The growing convolution of industries and the need for corporate business survival has created a cognizance dilemma on the nexus of earnings management and managerial compensation paradigm, especially in developing nations. Hence, this paper sought to examine the nexus of earnings management and managerial compensation in Nigerian manufacturing firms. The study collected panel data from audited annual financial reports of six selected manufacturing firms listed in the Nigeria Stock Exchange, covering the period from, 2012-2019. The data were analyzed using descriptive statistics, correlation and Panel Regression Model. The findings indicate that earnings management is a significant determinant of managerial remuneration. Therefore, the study concludes that managing earnings of firms has a positive significant relationship with executive remuneration, and as such compensation should be tied to performance of the firm in real values.
Saturation of finitely-generated submodules of free modules over Prüfer domains
Authors: Yengui Ihsen , Ben Amor Faten
Published: August 2022

We propose to give an algorithm for computing the $R$-saturation of a finitely-generated submodule of a free module $E$ over a Prüfer domain $R$. To do this, we start with the local case, that is, the case where $R$ is a valuation domain. After that, we consider the global case ($R$ is a Prüfer domain) using the dynamical method. The proposed algorithm is based on an algorithm given by Ducos, Monceur and Yengui in the case $E=R[X]^m$ which is reformulated here in a more general setting in order to reach a wider audience. The last section is devoted to the case where $R$ is a Bézout domain. Particular attention is paid to the case where $R$ is a principal ideal domain ($\mathbb{Z}$ as the main example).
Есенциални фосфолипиди при болести на черния дроб
Authors: Minarik Peter , Koscova Eva
Published: August 2022

Черният дроб е важен орган за метаболизма и имунната система. Високият прием на въглехидрати или прекомерната консумация на алкохол могат да отключат възпалителни процеси, водещи до развитие на мастна чернодробна болест. Прегледът на 25 изследвания, публикувани в научната литература, показа положителни резултати от употребата на есенциални фосфолипиди.
Eibischwurzelextrakt und Honig: Linderung des Hustens durch Schleimhautprotektion
Authors: Mueck Tobias
Published: August 2022

Die experimentelle Studie untersuchte die bioadhäsiven Eigenschaften von Hustensirupen mit Teilfraktionen aus Pflanzenextrakten mit und ohne Zusatz von Honig. Die Autoren der Studie stellten fest, dass der Zusatz von Honig die Adhäsionszeit auf der Schleimhaut im Modell verlängert und damit die physiko-chemische Reizlinderung verbessern kann. Als zusätzlicher reizlindernder Effekt zeigte sich, dass die untersuchten Sirupe die Durchlässigkeit der Schleimhaut für Noxen verringern können und auch hier u. a. der Zusatz von Honig zum Gesamteffekt beiträgt.
Frauenspezifische Besonderheiten in Bezug auf das Auftreten und die Behandlung der Obstipation
Authors: Landes Sabine
Published: August 2022

Eine Obstipation hat nicht nur Auswirkungen auf den täglichen Stuhlgang, sondern auch auf das Wohlbfinden der betroffenen Personen. Eine digitale Datenerhebung in mehr als 5.000 Personen zeigte: Frauen sind oft umfassender betroffen – physisch wie emotional. In Hinblick auf eine Behandlung zeigte sich in Studiendaten zu den Laxantien Bisacodyl und Natriumpicosulfat, dass Frauen schneller auf eine Laxantieneinnahme ansprachen und in Bezug auf ihre gesundheitsbezogene Lebensqualität stärker von einer Behandlung profitierten.
Pharmakokinetik von Ibuprofen: Vergleich der fixen Kombination Ibuprofen plus Coffein mit Ibuprofen Lysinat und Ibuprofen Säure
Authors: Weiser Thomas
Published: August 2022

Analgetika mit leicht löslichem Ibuprofen (z. B. als Lysinat) wurden mit dem Ziel entwickelt, durch schnellere Absorption im Magen-Darmtrakt eine schnellere Schmerzlinderung zu gewährleisten als Ibuprofen-Säure. Da die Magenfüllung einen erheblichen Einfluss auf die Absorption haben kann, untersuchten zwei Studien die Pharmakokinetik von Ibuprofen-Lysinat und Ibuprofen-Säure (in der Kombination mit Coffein) auf nüchternen Magen und nach einem Standardfrühstück. Eine schnellere Absorption von Ibuprofen als Lysinat konnte nur auf nüchternen Magen gezeigt werden; nach einem Frühstück war die Zeit bis zum Erreichen maximaler Plasmaspiegel bei Ibuprofen-Säure (mit Coffein) sogar geringer als bei Ibuprofen-Lysinat. Da Analgetika üblicherweise nicht auf nüchternen Magen eingenommen werden, relativiert dies die angeblichen Vorteile von Ibuprofen-Lysinat.
Leitlinien-Empfehlungen zur Behandlung der Bauchschmerzen (beim Reizdarmsyndrom)
Authors: Weiser Thomas
Published: August 2022

Bauchschmerzen sind häufig und beeinträchtigen die Lebensqualität. Zur Behandlung des Reizdarmsyndroms haben weltweit viele Fachgesellschaften Leitlinien formuliert. Übereinstimmend werden Spasmolytika zur Behandlung der Bauchschmerzen genannt. Welche Substanzen genau Eingang finden, richtet sich nach den verfügbaren Behandlungsoptionen. Auffallend ist, dass viele Leitlinien explizit Butylscopolamin und Pfefferminzöl empfehlen, während die Anwendung von Analgetika keine Option darstellt.
Rohtosalkoruusun juuriuute ja hunaja: yskän lievitys limakalvosuojan avulla
Authors: Mueck Tobias
Published: August 2022

Kokeellisessa tutkimuksessa selvitettiin kasviuutteita ja hunajaa tai pelkkiä kasviuutteita sisältävien yskänlääkkeiden bioadhesiivisia ominaisuuksia. Tutkijat osoittivat, että hunajan lisääminen pidensi kiinnittymisaikaa limakalvolle tutkimusmallissa parantaen siten ärsytyksen fysikaaliskemiallista lievitystä. Ylimääräisenä rauhoittavana vaikutuksena testatut yskänlääkkeet vähensivät myös limakalvojen läpäisevyyttä haitallisille aineille, ja myös tässä tapauksessa hunajan lisääminen paransi osaltaan kokonaisvaikutusta.
Farmacocinética de ibuprofeno: comparação da combinação fixa de ibuprofeno mais cafeína com lisinato de ibuprofeno e ácido de ibuprofeno
Authors: Weiser Thomas
Published: August 2022

Foram desenvolvidos analgésicos contendo ibuprofeno de dissolução rápida (p. ex., na forma de lisinato) com o objetivo de garantir um alívio mais rápido da dor do que com o ácido de ibuprofeno através da absorção mais rápida no trato gastrointestinal. Dado que o grau de enchimento gástrico pode ter uma influência significativa na absorção, dois estudos clínicos investigaram a farmacocinética de lisinato de ibuprofeno e de ácido de ibuprofeno (combinados com cafeína) em estômago vazio (em jejum) e após a ingestão de um pequeno-almoço padrão. A absorção do ibuprofeno na forma de lisinato apenas foi mais rápida quando tomado com o estômago vazio; após a ingestão de um pequeno-almoço padrão, o tempo para atingir o pico das concentrações plasmáticas com o ácido de ibuprofeno (com cafeína) foi na verdade mais curto do que com o lisinato de ibuprofeno. Dado que a ingestão dos analgésicos geralmente não se verifica com o estômago vazio, isto reduz as alegadas vantagens do lisinato de ibuprofeno.
Zdraví dospelí s ťažkým stresom a hypomagnezémiou profitujú z kombinácie horčíka a vitamínu B6
Authors: Eberlin Marion
Published: August 2022

Táto randomizovaná, jednoducho zaslepená klinická štúdia skúmala účinky suplementácie horčíkom v porovnaní s podávaním kombinácie horčíka a vitamínu B6. Zatiaľ čo v prípade stredne závažného stresu neboli významné rozdiely medzi skupinami v štúdii, pacienti s hypomagnezémiou a ťažkým alebo veľmi ťažkým stresom mali prospech z kombinácie horčíka a vitamínu B6.
Analgetiká s adjuvantnými látkami – kombinácia analgetík s kofeínom
Authors: Weiser Thomas
Published: August 2022

Prehľad organizácie Cochrane Collaboration porovnal analgetické účinky bežného analgetika s kombináciou analgetika a kofeínu. Prídavok kofeínu výrazne zvýšil podiel pacientov, ktorí zaznamenali účinnú úľavu od bolesti pri všetkých skúmaných bolestivých stavoch. Autori nezistili žiadne dôkazy závažných nežiaducich udalostí v súvislosti s analgetikom alebo kofeínom.
Macrogol – tratamentul constipației, bazat de ghiduri
Authors: Eberlin Marion , Schuett Tanja
Published: August 2022

Creșterea frecvenței scaunelor și îmbunătățirea consistenței scaunelor joacă un rol decisiv în diminuarea constipației. Directivele internaționale și cele naționale recunosc efectul pozitiv al macrogolului în legătură cu ambii parametrii, cu un număr mare de dovezi. Este considerat a fi bine tolerat și sigur. Unele directive recomandă laxativele stimulatoare bisacodyl și picosulfat de sodiu cu același grad de recomandare.
Makrogol – liečba zápchy založená na usmerneniach
Authors: Eberlin Marion , Schuett Tanja
Published: August 2022

Zvýšenie frekvencie defekácie a zlepšenie konzistencie stolice zohrávajú rozhodujúcu rolu pri úľave od zápchy. Medzinárodné aj národné usmernenia uznávajú pozitívny účinok makrogolu vo vzťahu k obom parametrom s vysokou úrovňou dôkazov. Považuje sa za dobre znášaný a bezpečný. Niektoré usmernenia odporúčajú stimulačné laxatíva bisakodyl a pikosulfát sodný v rovnakej miere.
Ambroxol reduces cough frequency (in the daytime and at night) and thereby improves concentration and quality of life
Authors: Mueck Tobias
Published: August 2022

The pharmacy-based study questioned customers who had used one of four different dosage forms of ambroxol for acute cough. The results illustrated the therapeutic benefits of ambroxol in self-medication of acute cough. The different dosage forms showed comparable efficacy.
Do caffeine-containing combination analgesics cause sleepless nights?
Authors: Weiser Thomas
Published: August 2022

No relevant effects on the sleep quality of subjects were found in two studies in which ibuprofen combined with 100 mg caffeine was taken three times daily. Of a total of 538 patients, medication-induced sleep problems occurred in only one to two in 100 participants. In one of the studies, only 0.8% of participants reported sleep disorders – exactly the same percentage as in the placebo arm.
Macrogol 4000 : automédication probante pour la constipation fonctionnelle
Authors: Eberlin Marion , Landes Sabine
Published: August 2022

Les préparations à base de macrogol comptent parmi les traitements de première ligne de la constipation chez les enfants et les adultes. Une analyse a confirmé l’efficacité et la tolérance du macrogol 4000 par rapport au lactulose et aux préparations de macrogol avec ajouts d’électrolytes. Ce laxatif osmotique est également une bonne recommandation pour des raisons pharmaco-économiques.
Dexibuprofén – portrét
Authors: Gazova Andrea , Kyselovic Jan , Koscova Eva
Published: August 2022

Dexibuprofén, farmakologicky aktívny enantiomér ibuprofénu, preukazuje dobrú účinnosť pri akútnej aj chronickej bolesti. Tento prehľad zhŕňa výsledky štúdií, ktoré potvrdzujú, že dexibuprofén je účinná a bezpečná alternatíva v porovnaní s ibuprofénom a inými inhibítormi COX.
Rinite Alérgica e poluição atmosférica: nova evidência clínica com cloridrato de fexofenadina 180 mg
Authors: Murrieta-Aguttes Margarita , Volonte Marina
Published: August 2022

A exposição a poluentes atmosféricos e as alterações climáticas são fatores que contribuem para aumentar a prevalência e a exacerbação dos sintomas de rinite alérgica (RA). A fexofenadina 180 mg tem-se mostrado eficaz no alívio dos sintomas de RA induzidos pelos pólenes e agravados pela poluição atmosférica num ensaio clínico aleatorizado controlado (ensaio FEXPOLSAR) utilizando um modelo de desafio de alérgeno controlado, reconhecido e validado de RA.
Better understanding of “21st century headache” via real-world data
Authors: Constantin Luminita , Eberlin Marion , Turudic Iva Igracki , Martin C. Martin C.
Published: August 2022

Throughout the world, headache is one of the main causes of limitations in daily life and/or unfitness to work. 50% of sufferers never consult a doctor and instead turn to self-medication. A recently published expert consensus investigated this phenomenon in more detail and associated it with a scientific concept called “21st century headache”.
Real-World-Daten helfen, „Kopfschmerz des 21. Jahrhunderts“ besser zu verstehen
Authors: Constantin Luminita , Eberlin Marion , Turudic Iva Igracki , Michel Martin C.
Published: August 2022

Weltweit gehört Kopfschmerz zu den Hauptursachen für Einschränkungen im Alltag bzw. Arbeitsunfähigkeit. Dennoch sucht die Hälfte der Betroffenen nie einen Arzt auf und greift stattdessen zur Selbstmedikation. Ein kürzlich veröffentlichter Expertenkonsens hat dieses Phänomen näher untersucht und bringt es in Zusammenhang mit einem wissenschaftlichen Konzept, das als „Kopfschmerz des 21. Jahrhunderts“ bezeichnet wird.
The probiotic Bacillus clausii is an effective treatment of acute diarrhea in children
Authors: Perez Marcos III , Greifenberg Dorothea M.
Published: August 2022

A systematic review and meta-analysis confirms that the probiotic Bacillus clausii is an effective treatment for acute diarrhea in childhood. It shortens the duration of diarrhea and associated hospitalization. New studies shed light on the mechanisms underlying these beneficial effects.
Das Probiotikum Bacillus clausii ist bei der Behandlung von akutem Durchfall bei Kindern wirksam
Authors: Perez Marcos , Greifenberg Dorothea
Published: August 2022

Eine systematische Recherche und Metaanalyse hat bestätigt, dass das Probiotikum Bacillus clausii bei der Behandlung von akutem Durchfall bei Kindern wirksam ist. Es verkürzt die Durchfalldauer und die damit verbundene Hospitalisierung. Neue Studien geben Aufschluss über den Mechanismus, der dieser positiven Wirkung zugrunde liegt.
Il probiotico Bacillus clausii è un trattamento efficace della diarrea acuta nei bambini
Authors: Perez Marcos III , Greifenberg Dorothea M.
Published: August 2022

Una revisione sistematica con metanalisi conferma che il probiotico Bacillus clausii è un trattamento efficace per la diarrea infantile acuta, accorciando la durata della diarrea e l’ospedalizzazione ad essa associata. Nuovi studi fanno luce sui meccanismi alla base di questi effetti benefici.
O probiótico Bacillus clausii é um tratamento eficaz da diarreia aguda nas crianças
Authors: Perez Marcos III , Greifenberg Dorothea M.
Published: August 2022

Uma revisão sistemática e uma meta-análise confirmam que o probiótico Bacillus clausii é um tratamento eficaz da diarreia aguda na infância. Reduz a duração da diarreia e do internamento associado à mesma. Foram efetuados novos estudos que clarificam os mecanismos subjacentes a estes efeitos benéficos.
Probiotics can prevent drug-induced gastrointestinal symptoms
Authors: Plomer Manuel , Perez Marcos III
Published: August 2022

Probiotics such as Bacillus clausii reduce the occurrence of gastrointestinal side effects of commonly used medications such as antibiotics and proton pump inhibitors in placebo-controlled randomized trials. Their use can make Helicobacter pylori eradication schemes more tolerable.
Probiotika können arzneimittelinduzierten gastrointestinalen Symptomen vorbeugen
Authors: Plomer Manuel , Perez Marcos
Published: August 2022

Probiotika wie Bacillus clausii haben in placebokontrollierten, randomisierten Studien gastrointestinale Nebenwirkungen von häufig eingesetzten Arzneimitteln wie Antibiotika und Protonenpumpenhemmern reduziert. Sie können eine Eradikationsbehandlung von Helicobacter pylori verträglicher machen.
A probiotikumok megelőzhetik a gyógyszerek okozta gyomor-bélrendszeri tüneteket
Authors: Plomer Manuel , Perez Marcos III
Published: August 2022

Az olyan probiotikumok, mint a Bacillus clausii, placebokontrollos, randomizált vizsgálatokban csökkentik az általánosan használt gyógyszerek, például az antibiotikumok és a protonpumpa-gátlók gasztrointesztinális mellékhatásainak előfordulását. Használatuk tolerálhatóbbá teheti a Helicobacter pylori-eradikációs programokat.
I probiotici possono prevenire i sintomi gastrointestinali indotti dai farmaci
Authors: Plomer Manuel , Perez Marcos III
Published: August 2022

I probiotici come il Bacillus clausii riducono la comparsa di effetti collaterali gastrointestinali di farmaci di uso comune, quali antibiotici e inibitori della pompa protonica, in studi randomizzati controllati con placebo. Il loro uso può rendere più tollerabili gli schemi di eradicazione dell’Helicobacter pylori.
Os probióticos podem impedir os sintomas gastrointestinais induzidos pelos fármacos
Authors: Plomer Manuel , Perez Marcos III
Published: August 2022

Os probióticos, como o Bacillus clausii, diminuem a ocorrência de efeitos secundários gastrointestinais de medicamentos utilizados comummente, como antibióticos e inibidores da bomba de protões, em ensaios aleatorizados controlados por placebo. A sua utilização pode tornar os esquemas de erradicação da Helicobacter pylori mais bem tolerados.
Makrogol 4000: bizonyítékokon alapuló öngyógyszerezés funkcionális székrekedés esetén
Authors: Eberlin Marion , Landes Sabine
Published: August 2022

A makrogolkészítmények a székrekedés egyik első vonalbeli kezelését jelentik gyermekeknél és felnőtteknél egyaránt. Egy áttekintő vizsgálat megerősítette a makrogol 4000 hatásosságát és tolerálhatóságát a laktulózzal és a hozzáadott elektrolitokat tartalmazó makrogolkészítményekkel összehasonlítva. Az ozmotikus hashajtó farmakoökonómiai okokból is megfelelő javaslat.
Macrogol 4000: automedicație bazată pe dovezi pentru constipația funcțională
Authors: Eberlin Marion , Landes Sabine
Published: August 2022

Preparatele cu macrogol sunt unul dintre tratamentele de primă linie pentru constipație atât la copii, cât și la adulți. O analiză a confirmat eficacitatea și tolerabilitatea macrogolului 4000 în comparație cu lactuloza și cu preparatele cu macrogol cu adaos de electroliți. Laxativul osmotic este o recomandare bună și din punct de vedere farmacoeconomic.
Fosfolipide esențiale în bolile ficatului gras
Authors: Minarik Peter , Koscova Eva
Published: August 2022

Ficatul este un organ important al metabolismului și al sistemului imunitar. Un aport excesiv de carbohidrați sau un consum excesiv de alcool pot declanșa procese inflamatorii și pot duce la apariția bolii ficatului gras. O analiză a literaturii de specialitate bazată pe 25 de studii a arătat efecte pozitive după utilizarea fosfolipidelor esențiale.
Intranasal triamcinolone acetonide effectively improves nasal symptoms and quality of life in patients with perennial allergic rhinitis
Authors: Amessou Mohamed , Leshcheva Elizaveta , Maslakov Aleksandr , Venkataraman Palak
Published: August 2022

Allergic rhinitis is a common problem with increasing prevalence. Two recent publications demonstrate that intranasal triamcinolone acetonide is an effective treatment that progressively improves nasal symptoms and quality of life in adult patients with perennial allergic rhinitis.
Intranasal verabreichtes Triamcinolonacetonid verbessert nasale Symptome und die Lebensqualität von Patienten mit ganzjähriger allergischer Rhinitis wirksam
Authors: Amessou Mohamed , Leshcheva Elizaveta , Maslakov Aleksandr , Venkataraman Palak
Published: August 2022

Die allergische Rhinitis ist ein häufiges Problem mit steigender Prävalenz. Zwei aktuelle Publikationen zeigen, dass intranasal verabreichtes Triamcinolonacetonid wirksam und zunehmend nasale Symptome und die Lebensqualität von Patienten mit ganzjähriger allergischer Rhinitis verbessert.
Το ενδορρινικό ακετονίδιο τριαμσινολόνης βελτιώνει αποτελεσματικά τα ρινικά συμπτώματα και την ποιότητα ζωής σε ασθενείς με ολοετή αλλεργική ρινίτιδα
Authors: Amessou Mohamed , Leshcheva Elizaveta , Maslakov Aleksandr , Venkataraman Palak
Published: August 2022

Η αλλεργική ρινίτιδα είναι ένα συχνό πρόβλημα με αυξανόμενο επιπολασμό. Δύο πρόσφατες δημοσιεύσεις καταδεικνύουν ότι το ενδορρινικό ακετονίδιο τριαμσινολόνης είναι μια αποτελεσματική θεραπεία που σταδιακά βελτιώνει τα ρινικά συμπτώματα και την ποιότητα ζωής σε ενήλικες ασθενείς με ολοετή αλλεργική ρινίτιδα.
La triamcinolona acetónido intranasal mejora eficazmente los síntomas nasales y la calidad de vida en pacientes con rinitis alérgica perenne
Authors: Amessou Mohamed , Leshcheva Elizaveta , Maslakov Aleksandr , Venkataraman Palak
Published: August 2022

La rinitis alérgica es un problema común con una prevalencia creciente. Dos publicaciones recientes demuestran que la triamcinolona acetónido intranasal es un fármaco eficaz que mejora progresivamente los síntomas nasales y la calidad de vida en pacientes adultos con rinitis alérgica perenne.
Il triamcinolone acetonide intranasale allevia efficacemente i sintomi nasali e migliora la qualità della vita dei pazienti con rinite allergica perenne
Authors: Amessou Mohamed , Leshcheva Elizaveta , Maslakov Aleksandr , Venkataraman Palak
Published: August 2022

La rinite allergica è un problema comune, la cui prevalenza è in aumento. Due recenti pubblicazioni dimostrano che il triamcinolone acetonide per uso intranasale è un trattamento efficace che migliora progressivamente i sintomi nasali e la qualità della vita dei pazienti adulti con rinite allergica perenne.
Lepšie porozumenie „bolesti hlavy 21. storočia“ pomocou údajov z reálneho sveta
Authors: Constantin Luminita , Eberlin Marion , Turudic Iva Igracki , Michel Martin C.
Published: August 2022

Bolesť hlavy je na celom svete jednou z hlavných príčin obmedzení v každodennom živote alebo neschopnosti pracovať. 50% trpiacich sa nikdy neporadí s lekárom a obracajú sa namiesto toho k samoliečbe. Nedávno publikovaný záver odborníkov podrobnejšie skúmal tento fenomén a spojil ho s vedeckou koncepciou nazývanou „bolesť hlavy 21. storočia“.
Una mejor comprensión del «dolor de cabeza del siglo XXI» a través de datos del mundo real
Authors: Constantin Luminita , Eberlin Marion , Turudic Iva Igracki , Michel Martin C.
Published: August 2022

El dolor de cabeza es una de las principales causas de limitación en la vida cotidiana y/o de incapacidad laboral en todo el mundo. El 50% de los afectados nunca acuden a un médico, sino que recurren a la automedicación. Un consenso de expertos publicado recientemente ha investigado este fenómeno con más detalle y lo ha asociado a un concepto científico denominado «dolor de cabeza del siglo XXI».
Mieux comprendre la « céphalée du 21è siècle » grâce à des données concrètes
Authors: Constantin Luminita , Turudic Iva Igracki , Martin C. Martin C.
Published: August 2022

À travers le monde, la céphalée est l’une des principales causes de limitations dans la vie quotidienne et/ou d’incapacité à travailler. 50% des personnes qui en souffrent ne consultent jamais de médecin et se tournent plutôt vers l’automédication. Un travail de consensus d’experts récemment publié a exploré ce phénomène plus en détail et l’a associé à un concept scientifique appelé « céphalée du 21è siècle ».
A „21. századi fejfájás” jobb megértése valós adatokon keresztül
Authors: Constantin Luminita , Eberlin Marion , Turudic Iva Igracki , Michel Martin C.
Published: August 2022

A fejfájás világszerte a mindennapi életben való korlátozottság és/vagy a munkaképtelenség egyik fő oka. Az érintettek 50%-a soha nem fordul orvoshoz, hanem öngyógyításhoz folyamodik. Egy nemrégiben közzétett szakértői konszenzus részletesebben vizsgálta ezt a jelenséget, és egy tudományos fogalommal, a „21. századi fejfájással” hozta összefüggésbe.
Update on the antibiotic treatment of uncomplicated skin abscesses
Authors: Sethmann Annette
Published: August 2022

Cutaneous abscesses are often caused by S. aureus. The most important therapeutic measure is drainage of the accumulated pus. Although the clinical benefit from additionally administering oral antibiotics is well-proven, the increasing problem of resistance has prompted growing criticism of this approach. Against this backdrop, it is therefore interesting that an antimicrobial action – even against MRSA – has been demonstrated for locally applied ammonium bituminosulfonates, which have long been used to treat abscesses.
Study confirms the effect of a supplement on the micronutrient content of breast milk
Authors: Seibel Jens
Published: August 2022

Even in countries with a high standard of living, the intake of essential nutrients by breast-feeding women is often inadequate – with potentially negative effects on the development of their baby. A randomised, double-blind, placebo-controlled study confirms the evidence in favour of daily supplementation with a combination of several micronutrients plus lutein and docosahexaenoic acid (DHA) during lactation.
Studie belegt den Effekt eines Supplements auf den Mikronährstoff-Gehalt in der Muttermilch
Authors: Seibel Jens
Published: August 2022

Selbst in Ländern mit hohem Lebensstandard sind stillende Frauen häufig unzureichend mit essenziellen Nährstoffen versorgt – mit unter Umständen negativen Auswirkungen auf die Entwicklung des Säuglings. Eine randomisierte, doppelblinde, placebokontrollierte Studie bestätigt die Evidenz für eine tägliche Supplementierung mit einer Kombination aus mehreren Mikronährstoffen plus Lutein und Docosahexaensäure (DHA) in der Stillzeit.
Stress symptoms: Evidence supporting a phytopharmaceutical product with new marketing authorisation in Germany
Authors: Kolb Christiane , Aziz-Kalbhenn Heba
Published: August 2022

Phytotherapeutics are used in many countries to treat stress symptoms such as mild sleep disorders, anxiety, increased irritability, tension and nervous restlessness. An established combination preparation is now also available in Germany. Two studies prove the benefit, both with real-life data and in a controlled volunteer study.
Stressbeschwerden: Evidenz eines Phytopharmakons mit Neuzulassung in Deutschland
Authors: Kolb Christiane , Aziz-Kalbhenn Heba
Published: August 2022

Phytotherapeutika werden in vielen Ländern zur Behandlung von Stressbeschwerden wie z. B. leichten Schlafstörungen, Ängstlichkeit, erhöhter Reizbarkeit, Anspannung und nervöser Unruhe eingesetzt. Ein etabliertes Kombinationspräparat ist nun auch in Deutschland erhältlich. Zwei Untersuchungen belegen den Nutzen, sowohl mit Real-Life-Daten als auch in einer kontrollierten Probandenstudie.
Une nouvelle association abaisse les mesures objectives et la perception subjective du stress
Authors: Noah Lionel
Published: August 2022

La réduction du stress négatif est un enjeu majeur pour préserver le bien-être. Une récente étude randomisée, en double aveugle et contrôlée contre placebo, menée sur des adultes en bonne santé et modérément stressés (Clinicaltrials.gov: NCT03262376 ; 25/0817) démontre les effets bénéfiques d’une association de magnésium, vitamines B (B6, B9, B12) et extraits de rhodiola et de thé vert par rapport à des indicateurs de stress objectifs et subjectifs. Elle a été plus efficace que l’un ou l’autre extrait seul.
Una nuova combinazione riduce le misure oggettive e la percezione soggettiva dello stress
Authors: Noah Lionel
Published: August 2022

La riduzione dello stress nocivo è una sfida chiave per la salvaguardia del benessere. Un recente studio randomizzato, in doppio cieco, controllato con placebo in adulti sani con stress moderato (Clinicaltrials.gov: NCT03262376; 25/0817) dimostra gli effetti benefici di una combinazione di magnesio, vitamine del gruppo B (B6, B9, B12) ed estratti di rodiola e tè verde sugli indicatori oggettivi e soggettivi di stress. La combinazione si è dimostrata più efficace rispetto ai singoli estratti da soli.
Uma nova combinação reduz medições objetivas e a perceção subjetiva do stress
Authors: Noah Lionel
Published: August 2022

A redução do stress nocivo é um desafio fundamental para preservar o bem-estar. Um estudo recente aleatorizado com dupla ocultação e controlado por placebo em adultos saudáveis com stress moderado (Clinicaltrials.gov: NCT03262376; 25/0817) demonstra os efeitos benéficos de uma combinação de magnésio, vitaminas B (B6, B9, B12) e extratos de rhodiola e chá verde em comparação com indicadores objetivos e subjetivos do stress. Foi mais eficaz do que qualquer um dos extratos por si só.
Nowe leczenie skojarzone zmniejsza obiektywne i subiektywne wskaźniki stresu
Authors: Noah Lionel
Published: August 2022

Zredukowanie szkodliwego stresu jest kluczowym wyzwaniem, aby móc zachować dobre samopoczucie. Niedawne badanie przeprowadzone metodą podwójnie ślepej próby, z randomizacją i grupą kontrolną placebo u zdrowych dorosłych odczuwających umiarkowany stres (Clinicaltrials.gov: NCT03262376; 25/0817) wykazało korzystny wpływ stosowania połączenia magnezu, witamin z grupy B (B6, B9, B12) oraz ekstraktów z różeńca i zielonej herbaty na obiektywne i subiektywne wskaźniki stresu. Połączenie to było skuteczniejsze niż stosowanie któregokolwiek z ekstraktów oddzielnie.
Yeni bir kombinasyon, nesnel önlemleri ve öznel stres algısını azaltır
Authors: Noah Lionel
Published: August 2022

Zararlı stresi azaltmak, sağlığınızı korumak için önemli bir mücadeledir. Orta derecede stresli sağlıklı yetişkinler üzerinde yapılan yeni, randomize, çift kör, plasebo kontrollü çalışmada (Clinicaltrials.gov: NCT03262376; 25/0817) Magnezyum, B vitaminleri (B6, B9, B12) ve rhodiola ve yeşil çay ekstrelerinden oluşan bir kombinasyonun stresin nesnel ve öznel göstergelerine karşı yararlı etkileri ortaya konulmuştur. Bu her ekstreden daha etkili olmuştur.
Hatmi Çiçeği kök ekstresi ve bal: Mukoproteksiyon yoluyla öksürüğü dindirme
Authors: Mueck Tobias
Published: August 2022

Deneysel çalışma, bitki özlerinin kısmi fraksiyonlarını içeren bal eklenmiş veya eklenmemiş öksürük şuruplarının biyoyapışkan özelliklerini incelemiştir. Çalışma yazarları, balın eklenmesinin modelde mukozaya yapışma süresini uzattığını ve böylece tahrişin fizikokimyasal dindirilmesini iyileştirdiğini tespit etmiştir. Ek bir yatıştırıcı etki olarak, test edilen şuruplar ayrıca zararlı maddelere karşı mukozal geçirgenliği de azaltmıştır ve burada da bal ilavesi genel etkiye katkıda bulunmuştur.
Сочетание магния и витамина B6 помогает здоровым взрослым с гипомагниемией и в состоянии тяжелого стресса
Authors: Eberlin Marion
Published: August 2022

В данном рандомизированном простом слепом клиническом исследовании изучались эффекты добавок магния по сравнению с комбинированным приемом магния и витамина B6. В то время как не было никаких существенных различий между исследуемыми группами в случае умеренного стресса, пациентам с гипомагниемией и тяжелым или очень тяжелым стрессом помогало сочетание магния и витамина B6.
Кофеин – бодрящий и ароматный, но безопасный!
Authors: Weiser Thomas
Published: August 2022

Европейское агентство по безопасности пищевых продуктов провело всестороннюю оценку рисков и пришло к выводу, что регулярное потребление кофеина в течение всей жизни в дозе до 400 мг в день в возрасте от 18 лет здоровыми взрослыми и до 200 мг беременными и кормящими женщинами может считаться безопасным. Поперечный анализ по разным странам показал, что потребление кофеина было в пределах безопасного диапазона у 95% опрошенных.
Makrogol – kılavuza dayalı konstipasyon tedavisi
Authors: Eberlin Marion , Schuett Tanja
Published: August 2022

Dışkı sıklığında artış ve dışkı tutarlılığında iyileşme konstipasyonun iyileşmesinde belirleyici rol oynamaktadır. Uluslararası kılavuzlar ve ulusal kılavuzlar, yüksek bir kanıt düzeyiyle makrogolun her iki parametreyle ilgili olumlu etkisini kabul etmektedir. İyi tolere edildiği ve güvenli olduğu kabul edilmektedir. Bazı kılavuzlarda aynı derecede tavsiye içeren uyarıcı laksatifler bisakodil ve sodyum pikosülfat da önerilmektedir.
Амброксол снижает частоту кашля (днем и ночью) и тем самым улучшает концентрацию внимания и качество жизни
Authors: Mueck Tobias
Published: August 2022

В аптечном исследовании были опрошены клиенты, которые использовали одну из четырех различных лекарственных форм амброксола при остром кашле. Результаты продемонстрировали терапевтические преимущества амброксола при самолечении острого кашля. Различные лекарственные формы показали сопоставимую эффективность.
Облегчение острого кашля с помощью сиропа от кашля с мукопротектором
Authors: Mueck Tobias
Published: August 2022

В двух рандомизированных слепых контролируемых многоцентровых исследованиях изучали терапевтический эффект химического и механического барьера в верхних дыхательных путях, создаваемого сиропом от кашля на основе полисахарида, смолы и меда, у детей с острым кашлем, связанным с простудой. Мукопротекция привела к значительному облегчению кашля у детей по сравнению с сиропом на основе карбоцистеина или плацебо. Положительный эффект был особенно выражен у детей с сильным кашлем и/или эпизодами ночного кашля.
Боль в животе, спазмы и дискомфорт ухудшают качество жизни женщин: обсервационное интернет-исследование, посвященное лечению
Authors: Weigmann Harald
Published: August 2022

В этом обсервационном интернет-исследовании 96% опрошенных женщин сообщили, что боль в животе, спазмы и дискомфорт иногда мешают их повседневной деятельности; 44% даже заявили, что это случалось часто. Пострадавшие считали, что симптомы можно успешно лечить с помощью гиосцина бутилбромида и − статистически − значительно менее успешно с помощью спиртовых растительных экстрактов или анальгетиков.
İn vitro virüs deaktivasyonundan klinik uygunluğu: soğuk algınlığında gliserol ve morina balığı tripsini içeren ağız spreyi
Authors: Schuett Tanja , Loehn Matthias
Published: August 2022

Gliserol ile kombine edilen tripsin soğuk algınlığı virüslerinin in vitro deaktivasyonuna neden olmuştur. Bir pilot çalışma ve karşılaştırmalı çok merkezli bir çalışma soğuk algınlığından mustarip hastaların boğaz spreyi olarak aktif maddeleri kullandıktan sonra viral yükteki in vivo azalmayı ve yaşam kalitelerindeki iyileşmeyi araştırmıştır. Sonuçlar viral yükte azalma, soğuk algınlığı süresinde kısalma ve yaşam kalitesinde iyileşme göstermiştir.
Слабительные для детей? Новое исследование подтверждает эффективность и переносимость бисакодила при длительном применении
Authors: Eberlin Marion
Published: August 2022

В ретроспективном исследовании изучались эффективность и переносимость длительного и регулярного применения бисакодила у детей. Даже при длительном приеме (средняя продолжительность лечения: 14 месяцев) бисакодил был эффективен, безопасен и хорошо переносился детьми. Опасения по поводу развития зависимости оказались необоснованными; у большинства пациентов бисакодил можно было постепенно отменить без изменения частоты стула.
Есенціальні фосфоліпіди при стеатозах печінки
Authors: Minarik Peter , Koscova Eva
Published: August 2022

Печінка є важливим органом метаболізму та імунної системи. Надлишок вуглеводів або надмірне споживання алкоголю може дати поштовх запальному процесу та призвести до розвитку стеатозу печінки. Огляд літератури, що стосувався 25 досліджень, показав позитивні ефекти після застосування есенціальних фосфоліпідів.
Эссенциальные фосфолипиды при жировых заболеваниях печени
Authors: Minarik Peter , Koscova Eva
Published: August 2022

Печень является важным органом обмена веществ и иммунной системы. Переизбыток углеводов или чрезмерное употребление алкоголя могут спровоцировать воспалительные процессы и привести к развитию жировой болезни печени. Обзор литературы, основанный на 25 исследованиях, показал положительный эффект после применения эссенциальных фосфолипидов.
Бисакодил: комплексные данные свидетельствуют об эффективном и безопасном применении при запоре
Authors: Landes Sabine , Eberlin Marion , Lange Robert
Published: August 2022

Впервые с тех пор, как бисакодил был сертифицирован в 1950-х годах, в новейшем обзоре была представлена подробная подборка фармакологических и клинических данных, касающихся этого прокинетического и секретагогического слабительного. На основе знаний, полученных в результате многолетнего опыта работы с этим препаратом, в обзоре представлены практические рекомендации для консультаций пациентов относительно еще более эффективного и безопасного использования бисакодила.