bluuebunny/crossref_metadata_2025 huggingface dataset:
Intermittent Fasting as a Potential Therapeutic Instrument for Major Depression Disorder: A Systematic Review of Clinical and Preclinical Studies
Authors: Murta Laís , Seixas Daniela , Harada Luana , Damiano Rodolfo Furlan , Zanetti Marcus
Published: October 2023

Recent studies have reported positive effects of Intermittent Fasting (IF) on metabolic parameters, cognition, and mood. However, regarding depressive symptoms, the effect of IF is not clear. The purpose of this review was to assess the available evidence on IF interventions for depression in both clinical and preclinical studies. Of the 23 included studies, 15 were performed on humans and 8 on animal models. The studies on rodents suggested that IF acts as a circadian regulator, improving neurotransmitter availability and increasing the levels of neurotrophic factors in the brain. However, the investigations on humans mainly evaluated healthy volunteers and showed a great heterogeneity regarding both the IF regimen studied and the observed effects on mood. Most available clinical trials have specific limitations, such as small sample sizes and uncontrolled designs. A comprehensive systematic review was conducted on five databases, PubMed, Cochrane, the Central Register of Controlled Trials, Web of Science databases, BVS and Scopus, identifying 23 relevant studies up to 6 October 2022. IF has potentially relevant physiological effects for the treatment of mood disorders, but better designed studies and controlled evaluations are needed to evaluate its efficiency in the treatment of major depression.
Effect of Reactive Oxygen Scavenger N,N′-Dimethylthiourea (DMTU) on Seed Germination and Radicle Elongation of Maize
Authors: Li Wei-Qing , Li Jia-Yu , Zhang Yi-Fei , Luo Wen-Qi , Dou Yi , Yu Song
Published: October 2023

Reactive oxygen species (ROS) are an important part of adaptation to biotic and abiotic stresses and regulate seed germination through positive or negative signaling. Seed adaptation to abiotic stress may be mediated by hydrogen peroxide (H2O2). The effects of the ROS scavenger N,N′-dimethylthiourea (DMTU) on maize seed germination through endogenous H2O2 regulation is unclear. In this study, we investigated the effects of different doses of DMTU on seed endogenous H2O2 and radicle development parameters using two maize varieties (ZD958 and DMY1). The inhibitory effect of DMTU on the germination rate and radicle growth was dose-dependent. The inhibitory effect of DMTU on radicle growth ceased after transferring maize seeds from DMTU to a water medium. Histochemical analyses showed that DMTU eliminated stable H2O2 accumulation in the radicle sheaths and radicles. The activity of antioxidant enzyme and the expression of antioxidant enzyme-related genes (ZmAPX2 and ZmCAT2) were reduced in maize seeds cultured with DMTU compared with normal culture conditions (0 mmol·dm−3 DMTU). We suggest the use of 200 mmol·dm−3 DMTU as an H2O2 scavenger to study the ROS equilibrium mechanisms during the germination of maize seeds, assisting in the future with the efficient development of plant growth regulators to enhance the seed germination performance of test maize varieties under abiotic stress.
The Arising Role of Extracellular Vesicles in Cholangiocarcinoma: A Rundown of the Current Knowledge Regarding Diagnostic and Therapeutic Approaches
Authors: Trifylli Eleni-Myrto , Kriebardis Anastasios G. , Koustas Evangelos , Papadopoulos Nikolaos , Vasileiadi Sofia , Fortis Sotirios P. , Tzounakas Vassilis L. , Anastasiadi Alkmini T. , Sarantis Panagiotis , Papageorgiou Effie G. , Tsagarakis Ariadne , Aloizos Georgios , Manolakopoulos Spilios , Deutsch Melanie
Published: October 2023

Cholangiocarcinomas (CCAs) constitute a heterogeneous group of highly malignant epithelial tumors arising from the biliary tree. This cluster of malignant tumors includes three distinct entities, the intrahepatic, perihilar, and distal CCAs, which are characterized by different epidemiological and molecular backgrounds, as well as prognosis and therapeutic approaches. The higher incidence of CCA over the last decades, the late diagnostic time that contributes to a high mortality and poor prognosis, as well as its chemoresistance, intensified the efforts of the scientific community for the development of novel diagnostic tools and therapeutic approaches. Extracellular vesicles (EVs) comprise highly heterogenic, multi-sized, membrane-enclosed nanostructures that are secreted by a large variety of cells via different routes of biogenesis. Their role in intercellular communication via their cargo that potentially contributes to disease development and progression, as well as their prospect as diagnostic biomarkers and therapeutic tools, has become the focus of interest of several current studies for several diseases, including CCA. The aim of this review is to give a rundown of the current knowledge regarding the emerging role of EVs in cholangiocarcinogenesis and their future perspectives as diagnostic and therapeutic tools.
Nipbl Haploinsufficiency Leads to Delayed Outflow Tract Septation and Aortic Valve Thickening
Authors: Boulet Fanny , Odelin Gaelle , Harrington Alenca , Moore-Morris Thomas
Published: October 2023

Cornelia de Lange Syndrome (CdLS) patients, who frequently carry a mutation in NIPBL, present an increased incidence of outflow tract (OFT)-related congenital heart defects (CHDs). Nipbl+/- mice recapitulate a number of phenotypic traits of CdLS patients, including a small body size and cardiac defects, but no study has specifically focused on the valves. Here, we show that adult Nipbl+/- mice present aortic valve thickening, a condition that has been associated with stenosis. During development, we observed that OFT septation and neural crest cell condensation was delayed in Nipbl+/- embryos. However, we did not observe defects in the deployment of the main lineages contributing to the semilunar valves. Indeed, endocardial endothelial-to-mesenchymal transition (EndMT), analysed via outflow tract explants, and neural crest migration, analysed via genetic lineage tracing, did not significantly differ in Nipbl+/- mice and their wild-type littermates. Our study provides the first direct evidence for valve formation defects in Nipbl+/- mice and points to specific developmental defects as an origin for valve disease in patients.
Arabidopsis 3β-Hydroxysteroid Dehydrogenases/C4-Decarboxylases Are Essential for the Pollen and Embryonic Development
Authors: Pan Jiawen , Li Weifeng , Chen Binzhao , Liu Linchuan , Zhang Jianjun , Li Jianming
Published: October 2023

The biosynthesis of C27–29 sterols from their C30 precursor squalene involves C24-alkylation and the removal of three methyl groups, including two at the C4 position. The two C4 demethylation reactions require a bifunctional enzyme known as 3β-hydroxysteroid dehydrogenase/C4-decarboxylase (3βHSD/D), which removes an oxidized methyl (carboxylic) group at C4 while simultaneously catalyzing the 3β-hydroxyl→3-keto oxidation. Its loss-of-function mutations cause ergosterol-dependent growth in yeast and congenital hemidysplasia with ichthyosiform erythroderma and limb defect (CHILD) syndrome in humans. Although plant 3βHSD/D enzymes were well studied enzymatically, their developmental functions remain unknown. Here we employed a CRISPR/Cas9-based genome-editing approach to generate knockout mutants for two Arabidopsis 3βHSD/D genes, HSD1 and HSD2, and discovered the male gametophytic lethality for the hsd1 hsd2 double mutation. Pollen-specific expression of HSD2 in the heterozygous hsd1 hsd2/+ mutant not only rescued the pollen lethality but also revealed the critical roles of the two HSD genes in embryogenesis. Our study thus demonstrated the essential functions of the two Arabidopsis 3βHSD/D genes in male gametogenesis and embryogenesis.
Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma
Authors: Zhai Lei , Balachandran Anushree , Larkin Rebecca , Seneviratne Janith A. , Chung Sylvia A. , Lalwani Amit , Tsubota Shoma , Beck Dominik , Kadomatsu Kenji , Beckers Anneleen , Durink Kaat , De Preter Katleen , Speleman Frank , Haber Michelle , Norris Murray D. , Swarbrick Alexander , Cheung Belamy B. , Marshall Glenn M. , Carter Daniel R.
Published: October 2023

MYCN amplification occurs in approximately 20–30% of neuroblastoma patients and correlates with poor prognosis. The TH-MYCN transgenic mouse model mimics the development of human high-risk neuroblastoma and provides strong evidence for the oncogenic function of MYCN. In this study, we identified mitotic dysregulation as a hallmark of tumor initiation in the pre-cancerous ganglia from TH-MYCN mice that persists through tumor progression. Single-cell quantitative-PCR of coeliac ganglia from 10-day-old TH-MYCN mice revealed overexpression of mitotic genes in a subpopulation of premalignant neuroblasts at a level similar to single cells derived from established tumors. Prophylactic treatment using antimitotic agents barasertib and vincristine significantly delayed the onset of tumor formation, reduced pre-malignant neuroblast hyperplasia, and prolonged survival in TH-MYCN mice. Analysis of human neuroblastoma tumor cohorts showed a strong correlation between dysregulated mitosis and features of MYCN amplification, such as MYC(N) transcriptional activity, poor overall survival, and other clinical predictors of aggressive disease. To explore the therapeutic potential of targeting mitotic dysregulation, we showed that genetic and chemical inhibition of mitosis led to selective cell death in neuroblastoma cell lines with MYCN over-expression. Moreover, combination therapy with antimitotic compounds and BCL2 inhibitors exploited mitotic stress induced by antimitotics and was synergistically toxic to neuroblastoma cell lines. These results collectively suggest that mitotic dysregulation is a key component of tumorigenesis in early neuroblasts, which can be inhibited by the combination of antimitotic compounds and pro-apoptotic compounds in MYCN-driven neuroblastoma.
Deep Learning Approaches for Big Data-Driven Metadata Extraction in Online Job Postings
Authors: Skondras Panagiotis , Zotos Nikos , Lagios Dimitris , Zervas Panagiotis , Giotopoulos Konstantinos C. , Tzimas Giannis
Published: October 2023

This article presents a study on the multi-class classification of job postings using machine learning algorithms. With the growth of online job platforms, there has been an influx of labor market data. Machine learning, particularly NLP, is increasingly used to analyze and classify job postings. However, the effectiveness of these algorithms largely hinges on the quality and volume of the training data. In our study, we propose a multi-class classification methodology for job postings, drawing on AI models such as text-davinci-003 and the quantized versions of Falcon 7b (Falcon), Wizardlm 7B (Wizardlm), and Vicuna 7B (Vicuna) to generate synthetic datasets. These synthetic data are employed in two use-case scenarios: (a) exclusively as training datasets composed of synthetic job postings (situations where no real data is available) and (b) as an augmentation method to bolster underrepresented job title categories. To evaluate our proposed method, we relied on two well-established approaches: the feedforward neural network (FFNN) and the BERT model. Both the use cases and training methods were assessed against a genuine job posting dataset to gauge classification accuracy. Our experiments substantiated the benefits of using synthetic data to enhance job posting classification. In the first scenario, the models’ performance matched, and occasionally exceeded, that of the real data. In the second scenario, the augmented classes consistently outperformed in most instances. This research confirms that AI-generated datasets can enhance the efficacy of NLP algorithms, especially in the domain of multi-class classification job postings. While data augmentation can boost model generalization, its impact varies. It is especially beneficial for simpler models like FNN. BERT, due to its context-aware architecture, also benefits from augmentation but sees limited improvement. Selecting the right type and amount of augmentation is essential.
The Effect of Cuelure on Attracting and Feeding Behavior in Zeugodacus tau (Walker) (Diptera: Tephritidae)
Authors: Liu Xuxiang , Zhang Qinyuan , Xu Weijie , Yang Yongbang , Fan Qingwen , Ji Qinge
Published: October 2023

As a vital pest control strategy, trapping plays an important role in the system of monitoring, catching and killing fruit flies. Cuelure (4-(4-acetoxyphenyl)-2-butanone, CL) is a male lure that attracts Zeugodacus tau and also stimulates feeding in this species. In this study, the attraction of Z. tau to CL and its subsequent feeding behavior were investigated. Under the significant influence of age and time of day, the attraction of CL to Z. tau was found to be optimal when flies were 14 days old, and the number of flies trapped increased with trapping duration. It was determined that consumption can improve the mating success and female adult fertility of Z. tau. After the observation period, the mating success rate of flies that ingested CL was significantly higher than that of the control group and was maintained at a higher level. It was found that parental consumption of CL could accelerate the development of eggs and larvae, resulting in increased pupation and emergence rates. The results of this study will further clarify the dynamic relationship between pest and lure, and provide a research basis for navigating the integrated management of Z. tau in the field.
Association between Neuron-Specific Enolase, Memory Function, and Postoperative Delirium after Transfemoral Aortic Valve Replacement
Authors: Nübel Jonathan , Buhre Charlotte , Hoffmeister Meike , Oess Stefanie , Labrenz Oliver , Jost Kerstin , Hauptmann Michael , Schön Julika , Fritz Georg , Butter Christian , Haase-Fielitz Anja
Published: October 2023

Introduction: Although transfemoral aortic valve replacement (TAVR) is a safe treatment for elderly patients with severe aortic valve stenosis, postoperative microembolism has been described. In this secondary endpoint analysis of the POST-TAVR trial, we aimed to investigate whether changes in neuron-specific enolase (NSE)—a biomarker of neuronal damage—are associated with changes in memory function or postoperative delirium (POD). Materials and Methods: This was a prospective single-center study enrolling patients undergoing elective TAVR. Serum NSE was measured before and 24 h after TAVR. POD was diagnosed using CAM-ICU testing. Memory function was assessed before TAVR and before hospital discharge using the “Consortium to Establish a Registry for Alzheimer’s Disease” (CERAD) word list and the digit span task (DST) implemented in “∆elta-App”. Results: Subjects’ median age was 82 years (25th to 75th percentile: 77.5–85.0), 42.6% of subjects were women. CERAD scores significantly increased from pre- to post-TAVR, with p < 0.001. POD occurred in 4.4% (6/135) of subjects at median 2 days after TAVR. After TAVR, NSE increased from a median of 1.85 ng/mL (1.30–2.53) to 2.37 ng/mL (1.69–3.07), p < 0.001. The median increase in NSE was 40.4% (13.1–138.0) in patients with POD versus 17.3% (3.3–43.4) in those without POD (p = 0.17). Conclusions: Memory function improved after TAVR, likely due to learning effects, with no association to change in NSE. Patients with POD appear to have significantly higher postoperative levels of NSE compared to patients without POD after TAVR. This finding suggests that neuronal damage, as indicated by NSE elevation, may not significantly impair assessed memory function after TAVR.
Exploring Mechanisms in COPD: Time for Biomarker Reappraisal?
Authors: Voulgareli Ilektra , Bakakos Petros , Loukides Stelios
Published: October 2023

Chronic obstructive pulmonary disease (COPD) is a widespread condition often overlooked in diagnosis [...]
Beyond Diameter: Enhancing Abdominal Aortic Aneurysm Surveillance with Volumetric Assessments after Endovascular Aneurysm Repair (EVAR)
Authors: Kargul Michał , Skórka Patryk , Gutowski Piotr , Kazimierczak Arkadiusz , Wiernicki Ireneusz , Rynio Paweł
Published: October 2023

This study aimed to investigate the relationship between maximum transverse diameter (MTD) and volume measurements in patients who underwent reoperations after endovascular aneurysm repair (EVAR), and their association with the occurrence of endoleaks. The study included 51 patients who underwent EVAR and subsequent re-operations caused by endoleaks type I–III. In some number of events, multiple re-operations were needed. MTD was measured using the Horos software, and segmentations of the AAA were performed using 3D Slicer. This study first evaluated post-operative computed tomography angiography (CTA) to measure MTD and volume. Then, similar measurements were made in the control scan for re-operation qualification. Negative remodeling (increase in MTD and/or volume) was observed in 40 cases using MTD, and 48 cases using volume measurements. The volume measurement showed lower missed negatives than MTD, indicating its effectiveness in screening for negative remodeling (p < 0.001). Combining both methods identified 51 negative remodeling cases and 8 positive changes, with a higher sensitivity compared to MTD alone. The volume of the sac did not predict specific endoleak types. Decreases in MTD were observed in smaller sacs, with smaller volume changes. Volume measurement is a valuable screening tool, and combining MTD and volume enhances sensitivity. However, sac volume does not predict endoleak type.
Mental Health for All: The Case for Investing in Digital Mental Health to Improve Global Outcomes, Access, and Innovation in Low-Resource Settings
Authors: Faria Manuel , Zin Stella Tan Pei , Chestnov Roman , Novak Anne Marie , Lev-Ari Shahar , Snyder Michael
Published: October 2023

Mental health disorders are an increasing global public health concern that contribute to morbidity, mortality, disability, and healthcare costs across the world. Biomedical and psychological research has come a long way in identifying the importance of mental health and its impact on behavioral risk factors, physiological health, and overall quality of life. Despite this, access to psychological and psychiatric services remains widely unavailable and is a challenge for many healthcare systems, particularly those in developing countries. This review article highlights the strengths and opportunities brought forward by digital mental health in narrowing this divide. Further, it points to the economic and societal benefits of effectively managing mental illness, making a case for investing resources into mental healthcare as a larger priority for large non-governmental organizations and individual nations across the globe.
Assessing the Accuracy of Spinal Instrumentation Using Augmented Reality (AR): A Systematic Review of the Literature and Meta-Analysis
Authors: Pahwa Bhavya , Azad Tej D. , Liu Jiaqi , Ran Kathleen , Liu Connor J. , Tracz Jovanna , Sattari Shahab Aldin , Khalifeh Jawad M. , Judy Brendan F. , Bydon Ali , Witham Timothy F.
Published: October 2023

Technological advancements, particularly in the realm of augmented reality (AR), may facilitate more accurate and precise pedicle screw placement. AR integrates virtual data into the operator’s real-world view, allowing for the visualization of patient-specific anatomy and navigated trajectories. We aimed to conduct a meta-analysis of the accuracy of pedicle screw placement using AR-based systems. A systematic review of the literature and meta-analysis was performed using the PubMed/MEDLINE database, including studies reporting the accuracy of pedicle screw placement using AR. In total, 8 studies with 163 patients and 1259 screws were included in the analysis. XVision (XVS) was the most commonly used AR system (595 screws) followed by the Allura AR surgical navigation system (ARSN) (462 screws). The overall accuracy was calculated as 97.2% (95% CI 96.2–98.1% p < 0.001). Subgroup analysis revealed that there was no statistically significant difference in the accuracy rates achieved by XVS and Allura ARSN (p = 0.092). AR enables reliable, accurate placement of spinal instrumentation. Future research efforts should focus on comparative studies, cost effectiveness, operative time, and radiation exposure.
Comparison of Early versus Traditional Rehabilitation Protocol after Rotator Cuff Repair: An Umbrella-Review
Authors: Paolucci Teresa , Agostini Francesco , Conti Marco , Cazzolla Sara , Mussomeli Elena , Santilli Gabriele , Poso Federica , Bernetti Andrea , Paoloni Marco , Mangone Massimiliano
Published: October 2023

Rehabilitation after rotator cuff repair is crucial for functional recovery and for minimizing the risk of retear. There are two rehabilitation protocols (early and traditional) and the debate about which is the best is open. This umbrella review aimed to compare the effect of these rehabilitation protocols in terms of reduction in pain, functional recovery, and retear risk. We selected systematic reviews and meta-analyses published between 2012 and 2022 dealing with the aim. Nineteen systematic reviews were included. No significant differences were found between early and traditional protocols in terms of pain reduction. Early rehabilitation provided better short-term results regarding Range of Motion improvement, but long-term functional outcomes were similar. Retear risk remains a significant concern for the early protocol. We found major differences between the analyzed protocols. This review suggests that both protocols are useful to recover global shoulder function, but the standard protocol has a greater safety profile for larger tears. On the other hand, the early protocol may be preferable for smaller lesions, allowing a faster recovery and having less impact on medical costs. Further research is needed to identify optimal rehabilitation strategies tailored to the individual patient’s needs and characteristics.
The Link between Periodontal Disease and Asthma: How Do These Two Diseases Affect Each Other?
Authors: Tamiya Hiroyuki , Abe Masanobu , Nagase Takahide , Mitani Akihisa
Published: October 2023

A growing body of evidence suggests that the effects of poor oral hygiene extend beyond the oral cavity and are associated with a variety of systemic diseases, including asthma. Asthma, which results in symptoms of cough, wheezing, and dyspnoea, and is characterized by airflow limitation with variability and (partial or complete) reversibility, is amongst the most prevalent respiratory diseases with approximately 262 million patients worldwide, and its prevalence and disease burden is on the increase. While asthma can occur at a young age, it can also develop later in life and affects a variety of age groups. Both of these diseases have a chronic course, and various researchers have suggested a link between the two. In this article, we aim to provide a literature review focusing on the association between the two diseases. The results demonstrate that medications (primarily, inhaler medicine), hypoxia induced by asthma, and the breathing behaviour of patients potentially trigger periodontal disease. In contrast, oral periodontopathogenic microorganisms and the inflammatory mediators produced by them may be involved in the onset and/or exacerbation of asthma. Common contributing factors, such as smoking, gastro-oesophageal reflux, and type-2 inflammation, should also be considered when evaluating the relationship between the two diseases.
Allogeneic Umbilical Cord Plasma Eyedrops for the Treatment of Recalcitrant Dry Eye Disease Patients
Authors: Wong Joy , Govindasamy Gayathri , Prasath Arun , Hwang William , Ho Aloysius , Yeo Sharon , Tong Louis
Published: October 2023

Background: Dry eye disease is a significant disease in Singapore. While there have been studies using allogenic cord serum for the treatment of dry eye disease, treatment of dry eyes with allogenic umbilical cord plasma drops has yet to be started in Singapore. Purpose: To evaluate the effectiveness of umbilical cord plasma eyedrops for the treatment of recalcitrant dry eyes in a local Singaporean context. Methods: This is an observational, longitudinal, interventional study for dry eye patients who did not show clear improvement after standard therapy. Patients were recruited from 2020 to 2023 from the dry eye clinic of the Singapore National Eye Center. Umbilical cord plasma was delivered frozen to patients and stored in home freezers. All participants underwent a standardized clinical evaluation for dry eye, and data were collected. Results: There were 40 participants (7 males and 33 females). The duration of follow-up was 5.52 ± 1.57 months. Kerato-epitheliopathy staining score, TBUT (tear breakup time), and SPEED (Standard Patient Evaluation of Eye Dryness Questionnaire) scores significantly improved after treatment. No statistically significant improvement was found in terms of visual acuity, according to Schirmer’s score. Conclusion: Cord plasma eye drops significantly improved kerato-epitheliopathy staining scores in recalcitrant dry eye patients. Allogeneic plasma is a promising form of treatment for recalcitrant dry eye.
Comparative Research on Topologies of Contra-Rotating Motors for Underwater Vehicles
Authors: Cheng Bo , Pang Shengzhao , Ou Huanyu , Hu Zeyan , Mao Zhaoyong
Published: October 2023

Underwater vehicles have been widely used in marine exploration and development. A contra-rotating propeller (CRP) can improve propulsion efficiency, eliminate the roll moment of the propeller acting on underwater vehicles, and significantly improve the dynamic performance of underwater vehicles. Contra-rotating motors (CRMs) are used to drive CRPs. Topologies of CRMs include an armature rotating contra-rotating motor (ARCRM), double contra-rotating motors (DCRMs), and a double rotor contra-rotating motor (DRCRM). In this paper, the design and optimization of these different topological CRMs were realized with analytical calculations of the magnetic field and electromagnetic performance. The efficiency map and losses analysis of CRMs with different topologies are obtained with the finite element method. In order to achieve suitable CRMs to drive the CRPs of underwater vehicles, three topologies for CRMs will be compared comprehensively from the perspective of structure, weight, size, loss, and efficiency. For low-speed, high-torque CRPs, the ARCRM has been proven to improve efficiency and power density. An ARCRM prototype was developed to verify this solution and its reliability.
Investigation of Physics-Informed Neural Networks to Reconstruct a Flow Field with High Resolution
Authors: Yang Zhou , Xu Yuwang , Jing Jionglin , Fu Xuepeng , Wang Bofu , Ren Haojie , Zhang Mengmeng , Sun Tongxiao
Published: October 2023

Particle image velocimetry (PIV) is a widely used experimental technique in ocean engineering, for instance, to study the vortex fields near marine risers and the wake fields behind wind turbines or ship propellers. However, the flow fields measured using PIV in water tanks or wind tunnels always have low resolution; hence, it is difficult to accurately reveal the mechanics behind the complex phenomena sometimes observed. In this paper, physics-informed neural networks (PINNs), which introduce the Navier–Stokes equations or the continuity equation into the loss function during training to reconstruct a flow field with high resolution, are investigated. The accuracy is compared with the cubic spline interpolation method and a classic neural network in a case study of reconstructing a two-dimensional flow field around a cylinder, which is obtained through direct numerical simulation. Finally, the validated PINN method is applied to reconstruct a flow field measured using PIV and shows good performance.
Replacing Mancozeb with Alternative Fungicides for the Control of Late Blight in Potato
Authors: Ben Naim Yariv , Cohen Yigal
Published: October 2023

Mancozeb (MZ) is a broadly used fungicide for the control of plant diseases, including late blight in potatoes caused by the oomycete Phytophthora infestans (Mont.) De Bary. MZ has been banned for agricultural use by the European Union as of January 2022 due to its hazards to humans and the environment. In a search for replacement fungicides, twenty-seven registered anti-oomycete fungicidal preparations were evaluated for their ability to mitigate the threat of this disease. Fourteen fungicides provided good control (≥75%) of late blight in potted potato and tomato plants in growth chambers. However, in Tunnel Experiment 1, only three fungicides provided effective control of P. infestans in potatoes: Cyazofamid (Ranman, a QiI inhibitor), Mandipropamid (Revus, a CAA inhibitor), and Oxathiapiprolin + Benthiavalicarb (Zorvek Endavia, an OSBP inhibitor + CAA inhibitor). In Tunnel Experiment 2, these three fungicides were applied at the recommended doses at 7-, 9-, and 21-day intervals, respectively, totaling 6, 4, and 2 sprays during the season. At 39 days post-inoculation (dpi), control efficacy increased in the following order: Zorvec Endavia > Ranman > Revus > Mancozeb. Two sprays of Zorvec Endavia were significantly more effective in controlling the blight than six sprays of Ranman or four sprays of Revus. We, therefore, recommend using these three fungicides as replacements for mancozeb for the control of late blight in potatoes. A spray program that alternates between these three fungicides may be effective in controlling the disease and also in avoiding the build-up of resistance in P. infestans to mandipropamid and oxathiapiprolin.
Balloon Eustachian Tuboplasty Combined or Not with Myringotomy in Eustachian Tube Dysfunction
Authors: Lin Wei-Chieh , Chang Yao-Wen , Kang Ting-Ya , Ye Ciou-Nan , Wu Hung-Pin , Lin Chung-Ching
Published: October 2023

Background: Eustachian tube dysfunction (ETD) is a common disorder causing ear pressure, pain, and hearing loss. Balloon Eustachian tuboplasty (BET) is an emerging technique for dilating the Eustachian tube and treating ETD. Whether adding myringotomy improves BET efficacy is controversial. Methods: This retrospective study included 95 ETD patients undergoing BET alone (n = 44) or BET with myringotomy (BET + M; n = 51) between June 2020 and August 2021 at a single medical center. The primary outcome was the change in ETDQ-7 symptom scores from baseline to 6 months after treatment. Secondary outcomes included audiometry, endoscopy, Valsalva maneuver, and complications. Results: The ETDQ-7 scores improved significantly after treatment in both groups (p < 0.001), without significant between-group differences (p = 0.417). No significant differences occurred in the audiometry, endoscopy, and Valsalva results or in most complications between groups. One BET + M patient had a persistent tympanic membrane perforation. Conclusions: Both BET alone and BET + M effectively and safely improved the subjective and objective ETD outcomes. However, adding myringotomy did not further improve the outcomes over BET alone, while it incurred risks such as persistent perforation. BET alone may sufficiently treat ETD without requiring myringotomy in this cohort. Further randomized controlled trials should identify optimal candidates for BET alone versus combined approaches.
The Role of Obstructive Sleep Apnea in Vision-Threatening Diabetic Retinopathy—A National Register-Based Study
Authors: Ba-Ali Shakoor , Jennum Poul Jørgen , Brøndsted Adam Elias , Heegaard Steffen , Lund-Andersen Henrik
Published: October 2023

Introduction: we investigated the association between OSA and vision-threatening diabetic retinopathy (VTDR). Methods: we used three nationwide registers to identify subjects with and without OSA and patients with type 1 (T1DM) or type 2 diabetes mellitus (T2DM). The Danish Civil Registration System was used to link OSA with diabetes diagnosis. The primary outcome was the occurrence of VTDR in diabetic patients with and without OSA. The secondary outcome was the prevalence of diabetes mellitus in patients with and without OSA. Results: we included 532,828 diabetic subjects comprising 13,279 patients with OSA (2.5%) and 519,549 without OSA (97.5%). Diabetic patients with OSA had a 57% lower risk of VTDR compared to diabetic patients without OSA (OR 0.43, 95% CI 0.38–0.50, p < 0.0001). Conclusions: our findings indicate that OSA is associated with a lower risk of VTDR. Since we did not adjust our outcomes for diabetes duration, hypertension control and hemoglobin A1c, future studies are needed to confirm our findings.
The Next Frontier in Sarcoma Care: Digital Health, AI, and the Quest for Precision Medicine
Authors: Fuchs Bruno , Studer Gabriela , Bode-Lesniewska Beata , Heesen Philip ,   on behalf of the Swiss Sarcoma Network
Published: October 2023

The landscape of sarcoma care is on the cusp of a transformative era, spurred by the convergence of digital health and artificial intelligence (AI). This perspectives article explores the multifaceted opportunities and challenges in leveraging these technologies for value-based, precision sarcoma care. We delineate the current state-of-the-art methodologies and technologies in sarcoma care and outline their practical implications for healthcare providers, administrators, and policymakers. The article also addresses the limitations of AI and digital health platforms, emphasizing the need for high-quality data and ethical considerations. We delineate the promise held by the synergy of digital health platforms and AI algorithms in enhancing data-driven decision-making, outcome analytics, and personalized treatment planning. The concept of a sarcoma digital twin serves as an illustrative paradigm for this integration, offering a comprehensive, patient-centric view of the healthcare journey. The paper concludes with proposals for future research aimed at advancing the field, including the need for randomized controlled trials or target trial emulations and studies focusing on ethical and economic aspects. While the road to this transformative care is laden with ethical, regulatory, and practical challenges, we believe that the potential benefits far outweigh the obstacles. We conclude with a call to action for multidisciplinary collaboration and systemic adoption of these technologies, underscoring the urgency to act now for the future betterment of sarcoma care and healthcare at large.
Impacts of Urbanization and Its Parameters on Thermal and Dynamic Fields in Hangzhou: A Sensitivity Study Using the Weather Research and Forecasting Urban Model
Authors: Wu Mengwen , Dong Meiying , Chen Feng , Yang Xuchao
Published: October 2023

The impact of urbanization and the sensitivity of urban canopy parameters (UCPs) on a typical summer rainfall event in Hangzhou, China, is investigated using three groups of ensemble experiments. In this case, urbanization leads to higher temperatures, lower mixing ratios, lower wind speeds before precipitation, and more precipitation in and around the urban area. Both the thermal and dynamical effects of urbanization contribute to an increase in temperature and precipitation, with thermal effects contributing 71.2% and 63.8% to the temperature and precipitation increase, respectively, while the thermal and dynamical impacts cause the opposite changes to the mixing ratio and wind speed. Compared to the other three meteorological elements, the model has the largest uncertainty in the simulation of precipitation, which includes the sensitivity of the different parameterization schemes to the simulation of precipitation in urban areas, and the uncertainty brought by the urban effect on precipitation is not confined within the city but extends to the surrounding areas as well. Temperature and mixing ratio are more sensitive to thermal-related UCPs, while the wind speed is mainly affected by the structural parameters. These variations, however, are sometimes contradictory to precipitation changes, which further adds to the complexity of precipitation simulation.
Landscape Structure and Fragmentation: Key Factors in the Characterisation of Urban and Peri-Urban Forests in Slovenia
Authors: Hladnik David , Nastran Mojca
Published: October 2023

Urban and peri-urban forests are strongly influenced by urbanisation and infrastructure-driven development. The main objective of the study is to evaluate and assess key factors characterising of urban and peri-urban forests in Slovenian regions with large differences in landscape fragmentation, from the Pannonian Plain to the Alps and the Mediterranean Sea. To assess landscape fragmentation and potential urban and peri-urban forests (UPFs), we used a spatial model of landscape structure and spatial characteristics of forests’ fragmentation and connectivity. The basis for estimating landscape structure and spatial characteristics of UPFs was tested for the 69 settlements with city status and for 150 smaller, rural settlements, which are the centres of individual municipalities. Of the 219 Slovenian settlements analysed, forest core areas within walking distance were estimated for 98% of the settlements. The proportion of the walking distance area with forest cover and 100 m or more from the forest edge is no more than one tenth of this area for 45% of Slovenian towns and for 42% of smaller settlements. By assessing the gradients of landscape ecological variables and accessibility of UPFs, it is possible to compare UPFs in different regions and take them into account when preparing guidelines for spatial planning based on landscape structure principles at the local level. Large differences in the landscape and UPF fragmentation within cities and settlements highlight the importance of spatial planning that adapts to the individuality of the landscape and each UPF.
Personalized Nasal Protective Devices: Importance and Perspectives
Authors: Quoc Thinh To , Bácskay Ildikó , Fehér Pálma , Pallér Ádám , Papp Boglárka , Bíró Krisztina , Ujhelyi Zoltán
Published: October 2023

Nowadays, in addition to diseases caused by environmental pollution, the importance of personalized protection against various infectious agents has become of paramount importance. Besides medicine, several technical and technological studies have been carried out to develop suitable devices. One such revolutionary solution is the use of personalized nasal filters, which allow our body to defend itself more effectively against external environmental damage and pathogens. These filters are small devices that are placed in the nose and specifically filter the inhaled environmental contaminants, allergens, and microorganisms according to individual needs. These devices not only play a key role in maintaining our health but also contribute to environmental protection, reducing the inhalation of pollutants and their harmful impact on the natural environment. Another advantage of personalized filters is that they also provide an opportunity to strengthen our individual immune systems. The use of personalized filters allows medicine to provide optimized protection for everyone, focusing on individual genetic and immunological conditions. The momentum behind the development and research of personalized nasal filters has reached astonishing proportions today. Nowadays, many research groups and medical institutions are working to create new materials, nanotechnologies, and bioinformatics solutions in order to create even more effective personalized nasal filters that can also be shaped easily and safely. Considering the needs of the users is at least as important during development as the efficiency of the device. These two properties together determine the success of the product. Industry research focuses not only on improving the efficiency of devices, but also on making them more responsive to user needs, comfort, and portability. Based on all this, it can be concluded that personalized nasal filters can be a promising and innovative solution for protection against environmental pollutants and pathogens. Through a commitment to the research and development of technology, the long-term impact of such devices on our health and the environment can be significant, contributing to improving people’s quality of life and creating a sustainable future. With unique solutions and continuous research, we give hope that in the future, despite the environmental challenges, we can enjoy the protection of our health with even more efficient and sophisticated devices.
Clinical Study of 14 Cases of Bone Augmentation with Selective Laser Melting Titanium Mesh Plates
Authors: Takahashi Ayaka , Inoue Kazuya , Imagawa-Fujimura Naoko , Matsumoto Keisuke , Yamada Kazuto , Sawai Yasuhisa , Nakajima Yoichiro , Mano Takamitsu , Kato-Kogoe Nahoko , Ueno Takaaki
Published: October 2023

Additive manufacturing techniques are being used in the medical field. Orthopedic hip prostheses and denture bases are designed and fabricated based on the patient’s computer-aided design (CAD) data. We attempted to incorporate this technique into dental implant bone augmentation. Surgical simulation was performed using patient data. Fourteen patients underwent bone augmentation using a selective laser melting (SLM) titanium mesh plate. The results showed no evidence of infection in any of the 14 patients. In 12 patients, only one fixation screw was used, and good results were obtained. The SLM titanium mesh plate was good adaptation in all cases, with bone occupancy greater than 90%. The average bone resorption of the marginal alveolar bone from the time of dental implant placement to the time of the superstructure placement was 0.69 ± 0.25 mm. Implant superstructures were placed in all cases, and bone augmentation with SLM titanium mesh plates was considered a useful technique.
Puncture Resistance and UV aging of Nanoparticle-Loaded Waterborne Polyurethane-Coated Polyester Textiles
Authors: Acierno Domenico , Graziosi Lucia , Patti Antonella
Published: October 2023

The goal of this research was to investigate the effect of different types of nanoparticles on the UV weathering resistance of polyurethane (PU) treatment in polyester-based fabrics. In this regard, zinc oxide nanoparticles (ZnO), hydrophilic silica nanoparticles (SiO2 (200)), hydrophobic silica nanoparticles (SiO2 (R812)), and carbon nanotubes (CNT) were mixed into a waterborne polyurethane dispersion and impregnated into textile samples. The puncturing resistance of the developed specimens was examined before and after UV-accelerated aging. The changes in chemical structure and surface appearance in nanoparticle-containing systems and after UV treatments were documented using microscopic pictures and infrared spectroscopy (in attenuated total reflectance mode). Polyurethane impregnation significantly enhanced the puncturing strength of the neat fabric and reduced the textile’s ability to be deformed. However, after UV aging, mechanical performance was reduced both in the neat and PU-impregnated specimens. After UV treatment, the average puncture strength of all nanoparticle-containing systems was always greater than that of aged fabrics impregnated with PU alone. In all cases, infrared spectroscopy revealed some slight differences in the absorbance intensity of characteristic peaks for polyurethane polymer in specimens before and after UV rays, which could be related to probable degradation effects.
Effect of Defects and Oxidation on CNT–Copper Interface: First-Principles Calculation and Experiment
Authors: Ju Boyu , Zhu Yubo , Yang Wenshu , Sun Jinpeng , Li Haozhe , Yuan Feng , Xiu Ziyang
Published: October 2023

In this paper, the effects of carbon nanotube defects and a copper surface oxide layer on a carbon nanotube–copper interface were studied via first-principles. A defect-free CNT-Cu interface, Stone–Wales defect CNT-Cu interface, single-hole and double-hole defect CNT-Cu interface, and Cu2O-Cu interface were simulated and calculated. By simulating the differential charge density, atomic population, bond population and density of states of the interface model, the effects of various defects on the interface bonding and electrical conductivity of the composites during the preparation of the CNT-reinforced copper matrix composites were analyzed, which provided theoretical guidance for the preparation of CNT/Cu composites. After that, copper matrix composites with different CNT defect contents were prepared via different rolling deformation processes. Their hardness and electrical conductivity were tested, and the results were consistent with the results obtained via the first-principles calculations.
Influence of Interface on Mechanical Behavior of Al-B4C/Al Laminated Composites under Quasi-Static and Impact Loading
Authors: Zhang Runwei , Chao Zhenlong , Jiang Longtao , Han Huimin , Han Bingzhuo , Du Shanqi , Luo Tian , Chen Guoqin , Mei Yong , Wu Gaohui
Published: October 2023

In this study, Al-B4C/Al laminated composites with high interlayer bonding strength were fabricated by integrated hot-pressed sintering accompanied with hot rolling. The mechanical properties and interface behavior of the Al-B4C/Al laminated composites were investigated under quasi-static and impact loading. The results show that the Al-B4C/Al laminated composites obtain a high interface bonding strength, because no interlayer delamination occurs even after fractures under quasi-static and impact loads. The Al-B4C/Al laminated composites exhibit a better comprehensive mechanical performance, and the fracture can be delayed due to the high bonding strength interface. Moreover, laminated composites can absorb more impact energy than the monolithic material under impact loading due to the stress transition and relaxation.
Microstructure of the Advanced Titanium Alloy VT8M-1 Subjected to Rotary Swaging
Authors: Dyakonov Grigory S. , Yakovleva Tatyana V. , Mironov Sergei Y. , Stotskiy Andrey G. , Modina Iulia M. , Semenova Irina P.
Published: October 2023

In this study, the microstructural behavior of the advanced Ti-5.7Al-3.8Mo-1.2Zr-1.3Sn-0.15Si (VT8M-1) alloy during rotary swaging (RS) was investigated. VT8M-1 has increased heat resistance and is considered a replacement for the Ti-6Al-4V alloy. It was shown that, during RS, the evolution of the primary a phase is characterized by the formation of predominantly low-angle boundaries according to the mechanism of continuous dynamic recrystallization. The density of low-angle boundaries increases three times: from 0.38 µm−1 to 1.21 µm−1 after RS. The process of spheroidization of the lamellar (a + b) component is incomplete. The average size of globular a and b particles was 0.3 μm (TEM). It is shown that the microstructures after RS (ε = 1.56) and equal-channel angular pressing (ECAP) (ε = 1.4) are significantly different. The temperature–velocity regime and the predominance of shear deformations during ECAP contributed to a noticeable refinement of the primary a-phase and a more complete development of globularization of the lamellar (a+b) component. EBSD studies have shown that RS leads to the formation of a structure with a higher density of low- and high-angle boundaries compared to the structure after ECAP. The results are useful for predicting alloy microstructure in the production of long rods that are further used in forging operations.