bluuebunny/crossref_metadata_2025 huggingface dataset:
Prinsip Kepemilikan Bersama Hak Cipta Dalam Naskah Film Soekarno
Authors: Izzah Ananda Elena Nurul
Published: June 2023

AbstractCopyright ownership dispute in the Soekarno film script between Rachmawati Soekarnoputri and PT. Tripar Multivision Plus, Ram Jethmal Punjabi, and Hanung Bramantyo have obtained permanent legal force, namely through Supreme Court Decision Number 305K/Pdt.Sus HKI/2014. The purpose of this study is to examine the status of Rachmawati Soekarnoputri in the film “Soekarno: Indonesia Merdeka” and its legal consequences, and to examine the principle of co-ownership of copyright in the film script “Soekarno: Indonesia Merdeka”. This study applies normative legal research methods, using a statutory, conceptual, and case approach. The results of the study show that the status of Rachmawati Soekarnoputri in Soekarno’s film only acts as a reference source (in addition to other reference sources). So based on the Copyright Law, the creator of the Soekarno film scenario, namely Ben Sihombing, was the owner of the copyright, and not Rachmawati Soekarnoputri. As for the principle of joint ownership, the laws and regulations in Indonesia still do not accommodate the joint ownership of the idea reference for filmmaking. However, in the implementation of moral rights, Rachmawati Soekarnoputri actually can still be named as a reference in the film as a form of joint ownership.Keywords: Soekarno Films; Copyright; Collective Ownership.
AbstrakSengketa kepemilikan hak cipta dalam naskah Film Soekarno antara Rachmawati Soekarnoputri dengan PT. Tripar Multivision Plus, Ram Jethmal Punjabi, dan Hanung Bramantyo telah memperoleh kekuatan hukum tetap, yakni melalui Putusan Mahkamah Agung Nomor 305K/Pdt.Sus HKI/2014. Tujuan dari penelitian ini adalah untuk mengkaji status Rachmawati Soekarnoputri dalam Film “Soekarno: Indonesia Merdeka” dan akibat hukumnya, serta mengkaji prinsip kepemilikan bersama hak cipta dalam naskah Film “Soekarno: Indonesia Merdeka”. Penelitian ini mengaplikasikan metode penelitian hukum normatif, dengan menggunakan pendekatan peraturan perundang-undangan, konseptual, dan kasus. Hasil penelitian mengetengahkan bahwa status Rachmawati Soekarnoputri dalam Film Soekarno hanya bertindak sebagai salah satu sumber referensi (selain sumber-sumber referensi lainnya). Sehingga berdasarkan UU Hak Cipta, pencipta skenario Film Soekarno, yakni Ben Sihombing lah selaku pemilik hak cipta, dan bukannya Rachmawati Soekarnoputri. Adapun berkaitan dengan prinsip kepemilikan bersama, peraturan perundang-undangan di Indonesia masih belum mengakomodir berkenaan dengan kepemilikan bersama terhadap pemberi referensi ide terhadap pembuatan film. Namun demikian, dalam pelaksanaan hak moral, Rachmawati Soekarnoputri sejatinya tetap dapat dicantumkan namanya sebagai pemberi refrensi dalam film tersebut sebagai wujud dalam hal kepemilikan bersama. Kata Kunci: Film Soekarno; Hak Cipta; Kepemilikan Bersama.
Keabsahan Bukti Elektronik Dalam Tindak Pidana Pencucian Uang di Pasar Modal Beserta Akibat Hukumnya
Authors: Batmomolin Modesta Anen M. , Saleh Moh.
Published: June 2023

AbstractDevelopments in technology and informatics have led to developments in crimes that are easier and can be carried out anywhere using smartphones. Money laundering is a crime that has an impact on development and social welfare. The capital market is a very attractive field for money laundering. The purpose of this study is to determine the validity of electronic evidence and legal consequences in money laundering crimes committed in the capital market. The research method used is normative law using an analytical approach to legislation. The research results will be presented in a qualitative descriptive manner, so that data can be obtained that can compare theories with existing facts. The results of the study show that evidence in the form of electronic information and documents is valid to be used in deciding on money laundering crimes. As a result of the law, perpetrators of money laundering in the capital market can be sentenced to a maximum fine of Rp. 10,000,000,000,00,- (ten billion rupiahs) or imprisonment for a maximum of 20 (twenty) years in accordance with the articles in law number 8 of 2010.Keywords: Money Laundering; Electronic Media; Capital Markets.
AbstrakPerkembangan teknologi dan informatika menyebabkan perkembangan dalam tindak pidana kejahatan yang lebih mudah dan dilakukan dimanapun mengguanakan telepon cerdas. Pencucian uang merupakan kejahatan yang memberikan dampak dalam pembangunan dan kesejahteraan sosial. Pasar modal menjadi ladang yang sangat menarik untuk melakukan pencucian uang. Tujuan penelitian ini untuk mengetahui keabsahan alat bukti elektronik dan akibat hukum dalam tindak pidana pencucian uang yang dilakukan di pasar modal. Metode penelitian yang digunakan yaitu hukum normatif menggunakan pendekatan analitis perundang-undangan. Hasil penelitian akan disajikan secara deskriptif kualitatif, sehingga didapat data yang dapat membandingkan teori-teori dengan fakta yang ada. Hasil penelitian menunjukkan jika alat bukti berupa informasi dan dokumen elektronik sah digunakan dalam memutuskan pidana pencucian uang. Akibat hukum pelaku pencucian uang di pasar modal dapat dijatuhi hukuman pidana denda paling banyak Rp. 10.000.000.000,00,- (sepuluh miliar rupiah) maupun kurungan penjara paling lama 20 (dua puluh) tahun penjara sesuai dengan pasal-pasal dalam Undang-Undang Nomor 8 Tahun 2010. Kata Kunci: Tindak Pidana Pencucian Uang; Media Elektronik; Bursa Efek.
Inter-Religious Marriage: A Comparison Analysis of Indonesian Law With Other Countries
Authors: Hidayatullah Tomi , Moechthar Oemar , Aprilia Dimipta
Published: June 2023

AbstractInter-religious marriage is not something new in Indonesia. Judging from the diversity of religions that exist, it does not rule out the possibility of inter-religious marriages. However, inter-religious marriage is still a polemic among the public because the Law of the Republic of Indonesia Number 1 of 1974 concerning Marriage, does not explicitly regulate and accommodate the problem of inter-religious marriage, especially after the enactment of Law Number 23 of 2006 concerning Administration Population, the opportunity to legalize inter-religious marriages seems to be wide open, namely with the availability of the option of submitting an application for interfaith marriages to the District Court to issue a stipulation allowing interfaith marriages and instructing Civil Registry office employees to record these interfaith marriages into Register of Marriage Registration. In the end, people often smuggle laws in ways that are not justified, for example by providing false information that they have changed religions and follow the religion of their partners. Or by carrying out marriages abroad which allow marriages of different religions, and then registering them at the civil registry office. This study aims to find out how Indonesian law views inter-religious marriages and how inter-religious marriages are regulated from a comparison of the laws of other countries, such as those in Canada, Singapore, England and the Netherlands. This study uses a statutory approach, namely an approach that is carried out by examining all laws and regulations that are related to the legal issues under study. The results of this study will provide input to Indonesian legislators which can be used as an improvement in regulations, especially provisions related to inter-religious marriage.Keywords: Interfaith Marriage; Reduced Inequalities; Comparative Civil Law; Peace and Justice.
Dietary inclusion of African bush mango (Irvingia gabonensis) seed improves sexual performance in sexually inexperienced rats
Authors: Omojokun Olasunkanmi , Famurewa Akindele , Oboh Ganiyu , Enang Jemima , Ijeh Stella
Published: June 2023

Background: Erectile dysfunction (ED) is a sexual dysfunction characterized by the persistent inability to develop or maintain an erection of penis sufficient for satisfactory sexual relation. Synthetic aphrodisiacs have reportedly been used for the management of ED, but they present with some side effects. This research sought to evaluate the enhancing potential of diet-supplemented African bush mango (ABM) seed on erectile function in sexually inexperienced rats. Results: For this study, weaned male (28) and female (28) rats were procured. Rats were separately nurtured to maturity and grouped into four of seven rats in a group (n = 7). Group 1 received basal diet, Group 2 received basal diet with sildenafil (5 mg/kg body weight), Group 3 were fed diet with 10% ABM seed inclusion, while Group 4 were fed diet with 20% ABM seed inclusion. The experiment lasted for 21 days after which behavioral studies involving sexual and anxiety indices/measurements, lipid peroxidation, and enzyme assays (arginase and phosphodiesterase-5 [PDE-5]) were conducted. The group with diet inclusion containing 20% ABM showed an obviously increased sexual behavior similar to the group that received sildenafil. Arginase and PDE-5 inhibitory activities were also higher in the same group. Conclusion: This study suggests that ABM promotes sexual behavior and improves penile erection as a treatment for ED, justifying its use in folk medicine for this purpose.
Developed Method. Interactions and Their Quantum Picture
Authors: Ogonowski Piotr
Published: June 2023

By developing the previously proposed method of combining continuum mechanics with Einstein Field Equations, a complete description of the physical system was obtained. The density of the Lagrangian for the system turns out to be equal to the invariant of the electromagnetic field tensor, vanishing four-divergence of canonical four-momentum appears to be consequence of the Poyinting theorem, and explicit form of one of gauges of the electromagnetic four-potential was introduced. A quantum picture of the system was also proposed, leading to the Klein-Gordon equation, which seems to finally reconcile the curvilinear description, classic relativistic description and quantum description of the physical system.
Effects on Virulence Factors and Mechanisms Involved in Antimicrobial Sonophotodynamic Therapy Mediated by Curcumin
Authors: Alves Fernanda , Mayumi Inada Natália , Pratavieira Sebastião , Barrera Patiño Claudia Patricia , Kurachi Cristina
Published: June 2023

Due to the progression of antimicrobial resistance, Photodynamic (aPDT) and Sonodynamic (SDT) Therapies arose as promising approaches for microbial control. Recently, the combination of both therapies, called Sonophotodynamic Therapy (SPDT), have shown greater effects than the single treatments. This study evaluated the effects of aPDT, SDT and SPDT mediated by curcumin on the metabolism, adhesion capacity, biofilm formation ability and structural alteration in the Staphylococcus aureus biofilm. Moreover, possible antimicrobial mechanisms involved, such as the production of reactive oxygen species (ROS) and the degradation spectrum of curcumin by light, ultrasound and light+ultrasound, were measured. SPDT was more effective to inactivate the biofilm than aPDT and SDT. All treatments reduced the adhesion ability of the bacteria and it is probably related to the metabolism cell reduction. Regarding to the biofilm formation ability, all treatments reduced the total biomass. One possible mechanism involved in the inactivation is the ROS production observed. Curcumin had a significantly decay in its absorbance with the application of light, and a slighter one caused by the ultrasound. Finally, all treatments impacted the biofilm components and structure, reducing the cells and matrix. In conclusion, SPDT was more effective in the inactivation, and all treatments had the same effect in the virulence factors evaluated.
Blockchain Protocols & Edge Computing Targeting Industry 5.0 Needs
Authors: Oliveira Miguel , Chauhan Sumit , Pereira Filipe Alexandre , Felgueiras Manuel Carlos , Carvalho David Vieira
Published: June 2023

"Industry 5.0” is the latest industrial revolution. A variety of cutting-edge technologies, including artificial intelligence, the Internet of Things (IoT), and others, come together to form it. This new era will bring about significant changes in the way businesses operate, allowing them to become more cost-effective, more efficient, and produce higher-quality goods and services. Because sen-sors are getting better, 5G networks are being put in place, and more industrial equipment and machinery are becoming available, the manufacturing sector is going through a significant period of transition right now. These newly scalable opportunities make it possible to use and spread blockchain architectures on the shop floor, which is made possible by the ever-decreasing costs associated with implementing blockchain technology. Even though modern production models make use of the cloud (both internal and external services), networks and systems can take ad-vantage of the cloud's relatively low cost, scalability, increased computational power, real-time communication, and data transfer capabilities to create much smarter and more autonomous systems. This paper presents the results of an investigation into how blockchain services for large-scale industry networks could benefit from increased levels of security, transparency, and efficiency.

We discuss the ways in which decentralized networks that make use of protocols and meshes might make things better with these technologies, which are not going away anytime soon. We emphasize the significance of new design in regards to cybersecurity, data integrity, and storage by using straightforward examples that have the potential to lead to the excellence of distributed systems.
CfDNA and Caspase-3 Levels in Patients with Chronic Kidney Disease
Authors: Clementi Anna , Virzì Grazia Maria , Manani Sabrina Milan , De Cal Massimo , Battaglia Giovanni Giorgio , Ronco Claudio , Zanella Monica
Published: June 2023

Background: Cell-free plasma DNA (cfDNA) is composed of circulating extracellular DNA originating from apoptosis or cell necrosis. It is generally present in healthy individuals, but its levels increase in different clinical conditions, such as kidney disease, sepsis, myocardial infarction, trauma and cancer. Caspase-3 plays a central role in apoptosis, a mechanism of programmed cell death involved in the pathogenesis of chronic kidney disease (CKD). Methods: We compared cfDNA and caspase-3 levels in 25 CKD patients and in 10 healthy subjects, evaluating the modification of their concentrations according to CKD stage. We also analyzed the correlation between cfDNA and caspase-3 levels in CKD patients and the correlation between cfDNA and caspase-3 levels and creatinine and urea. Results: CfDNA and caspase-3 levels were higher in CKD patients compared to healthy subjects, in particular in patients with advanced renal disease. A positive correlation between cfDNA and caspase-3 levels and between cfDNA and caspase-3 and creatinine and urea was also observed. Conclusion: Patients with chronic kidney disease present higher levels of cfDNA and caspase-3 levels compared with healthy subjects. The worsening of renal damage and the increase in uremic toxin concentration are associated to higher levels of cfDNA and caspase-3 levels, thus reflecting a central role of apoptosis in the pathogenesis of CKD.
Overview of High-dimensional Measurement Error Regression Models
Authors: Luo Jingxuan , Yue Lili , Li Gaorong
Published: June 2023

High-dimensional measurement error data are becoming more prevalent across various fields. Research on measurement error regression models has gained increasing attention due to the risk of drawing inaccurate conclusions if measurement errors are ignored. When the dimension p is larger than the sample size n, it is challenging to develop statistical inference methods for high-dimensional measurement error regression models due to the existence of bias, nonconvexity of objective function, high computational cost and many other difficulties. Over the past few years, some works have overcome the aforementioned difficulties and proposed several statistical inference methods. This paper mainly reviews the current development on estimation, hypothesis testing and variable screening methods for high-dimensional measurement error regression models and shows the theoretical results of these methods with some directions worthy of exploring for future research.
Longitudinal Cognitive Trajectories in Older Adults with Rest-less Legs Syndrome or Willis-Ekbom Disease
Authors: Liampas Ioannis , Siokas Vasileios , Andreas Andreas , Sakoutis George , Yannakoulia Mary , Kosmidis Mary H , Sakka Paraskevi , Scarmeas Nikolaos , Georgios M. Hadjigeorgiou Georgios M , Dardiotis Efthimios
Published: June 2023

Abstract: Background: Restless Legs Syndrome /Willis-Ekbom disease (RLS/WED) has occasionally -but not consistently- been associated with cognitive, and most notably, language and executive impairment. The present study was conducted to investigate the cognitive trajectories of older individuals with RLS/WED. Methods: Participants were drawn from the randomly selected, older (>64 years), population-based HELIAD cohort. Individuals without dementia, with available neuropsychological evaluations at baseline and follow-up were considered for potential eligibility. A comprehensive assessment examining five principal components of cognition (memory, visuo-spatial ability, attention, executive function, and language) was administered to the partici-pants. Generalized estimating equations analysis was used to examine the unadjusted and adjusted (for critical factors and covariates) effects of RLS/WED on cognition over time. Results: A total of 1003 predominantly female, older (72.9 ±4.9 years) partici-pants, with follow-up evaluations after a mean of 3.09 ±0.85 years and without demen-tia at baseline and follow-up were included in the present study. Among them, 81 were diagnosed with RLS/WED at baseline. Global cognition, memory, attention, executive and visuo-perceptual skills did not differ between those with and without RLS/WED. However, the RLS/WED group performed worse on language at baseline by 0.249 of a standard deviation, while demonstrating a mitigated language decline over time, by 0.063 of a standard deviation. The unadjusted models yielded similar results. Conclu-sions: Our findings were indicative of a baseline language disadvantage among older individuals with RLS/WED, but the initial discrepancy tends to dissolve over time.
Ex Vivo Drug Testing of Patient-Derived Lung Organoids to Predict Treatment Responses for Personalized Medicine
Authors: Hung Chia-Nung , Williams Maddison , Williams Ryan , Chen Meizhen , Kamali Samaneh , Sambandam Vaishnavi , Chiu Cheryl Hsiang-Ling , Osmulski Pawel , Gaczynska Maria , DeArmond Daniel , Gaspard Christine , Macini Maria , Song Lina , Jin Lingtao , Schiavini Paolo , Chen Chun-Liang , Taverna Josephine
Published: June 2023

Lung cancer is the leading cause of global cancer-related mortality resulting in ~1.8 million deaths annually. Systemic, molecular targeted, and immune therapies have provided significant improvements of survival outcomes for patients. However, drug resistance usually arises and there is an urgent need for novel therapy screening and personalized medicine. 3D patient-derived organoid (PDO) models have emerged as a more effective and efficient alternative for ex vivo drug screening than 2D cell culture and patient-derived xenograft (PDX) models. In this review, we performed an extensive search of lung cancer PDO-based ex vivo drug screening studies. Lung cancer PDOs were successfully established from fresh or biobanked sections/biopsy of lung tumors, PDXs, and pleural affusion. PDOs were subject to ex vivo drug screening with chemotherapy, targeted therapy and immune therapy agents. PDOs mainly recapitulated the genomic alterations, transcriptomic landscape and drug sensitivity of primary tumors. Although sample sizes of the previous studies were limited and some technical challenges remained, PDOs showed promise to screen novel therapy drugs. With the technical advance of high throughput, tumor-on-chip, combined microenvironment, and air-liquid interface (ALI), the drug screening using PDOs would serve better for precision care of lung cancer patients.
Study of the Efficiency of Layered Double Hydroxide-based Corrosion Inhibitors on Mild Steel in Chemical Pickling in HCl Medium
Authors: Salim Ayoub , Elharrari Said , Guilbert Gregory , Lahem Driss , Semane Adnane , Harrad Mohamed Anouar , Badreddine Mohammed , Legrouri Ahmed , Takky Driss , Naimi Youssef
Published: June 2023

The materials used as corrosion inhibitors are [Zn-Al-Cl], [Mg-Al-Cl], [Ni-Fe-Cl], and [Co-Fe-Cl] layered double hydroxides (LDHs). They were synthesized by coprecipitation and characterized by X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), and thermal anal-yses. The efficiency of these corrosion inhibitors on mild steel in concentrated hydrochloric acid (18.5%) at 60°C (chemical pickling conditions of steel) was studied using electrochemical and gravimetric methods for different concentrations. The surface morphology and composition were examined by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), respectively. The inhibitory efficiency in the case of 1.2 g.L-1 LDH was found to be 83.33%, 83.65%, 68.38%, and 74.73% for [Ni- Fe-Cl], [Zn-Al-Cl], [Co-Fe-Cl], and [Mg-Al-Cl], respectively.
Sustainable Health Education Simulator Using Open-Source Technology
Authors: Oyarzún-Diaz Patricia , Orellana Ana , Segura Hugo , Vidal-Silva Cristian , Sánchez Aurora , Serrano Jorge
Published: June 2023

The information society has transformed human life. Technology is almost everywhere, including health and education. For example, years ago, speech and language therapy students required a long time and high-cost equipment to develop healthcare of the auditory and vestibular systems competencies. The high cost of the equipment permitted its practical use only in classes, hindering students’ autonomy in developing those competencies. That situation was a real issue, even more in times of pandemic where online education was essential. This article describes SAEF, an open-source software simulator for autonomously developing procedural audiology therapy competencies, user acceptance, and the validity of experiments and results. SAEF delivers immediate feedback and performance results. Obtained results permit validating students’ and educators’ acceptability of SAEF in audiology therapy education. Obtained results invite authors to continue developing simulator software solutions in other health education contexts. SAEF was developed using open-source technology to facilitate its accessibility, classification, and sustainability.
Investigation on Dynamic Behavior of Ultra-Large Cold-water Pipe for Ocean Thermal Energy Conversion
Authors: Zhang Yanfang , Zheng Miaozi , Zhang Li , Zhang Chaofei , Tan Jian , Zhang Yulong , Duan Menglan
Published: June 2023

Ultra-large cold-water pipes (CWP) may present structural instability phenomenon under complex and variable operating conditions, and the current theoretical analysis rarely takes into account the influence of multiple key parameters at the same time, resulting in some errors between the prediction results and the actual deformation behavior of the pipe. Considering this issue, this paper establishes a computational analysis model of the mechanical performance of the CWP based on the Euler-Bernoulli beam theory, considering the effect of waves, the clump weight at the bottom, internal flow and sea current, and gives a time-dependent solution of the mechanical response of the pipe with the action of multiple key parameters using the differential quadrature method (DQM). Additionally, the correctness and validity of the theoretical model are well verified by comparing the numerical solution with the theoretical results. Finally, to study the effects of operating conditions on the mechanical response of the pipe, the effects of waves, the clump weight, internal flow and sea current on the lateral deflection and maximum bending moment of the pipeline are discussed based on numerical simulation and orthogonal experimental method. The results show that changing the wave strength and internal flow velocity has little effect on the lateral deflection of the CWP, and the clump weight at the bottom can effectively suppress the lateral deflection of the pipeline, but increasing the current velocity can significantly increase the lateral deflection of the pipeline, which can lead to the instability of the pipe. Nevertheless, the effects of waves, the clump weight, internal flow and sea current on the maximum bending moment of the pipeline are basically the same, all of them increase sharply at first, and then decrease gradually until they level off, and the differences in the effects are mainly reflected in the different locations of the pipe sections. This paper suggests the design guidance of CWP in aspect of dynamic response depending on the operating condition.
Research on Four-channel Wide Dynamic Microwave Rectifier with a Shared Load
Authors: Peng Cheng , Ye Zhihao , Zhao Biao , Xiao Han , Wang Zerun
Published: June 2023

This paper has designed a four-channel wide dynamic microwave rectifier circuit for the shortcomings of uneven output voltage of each branch of the multi-channel rectification technology. A voltage-doubling rectifier circuit with identical structure was used in each branch. The four rectifier branches shared the same load at the output terminal, allowing the rectifier circuit to have an RF-DC conversion efficiency greater than 50% over the input power range from 12mW to 274mW, widened by 274% compared to a single channel. Not only the advantages of multi-channel technology with wide dynamics were retained, but also the output voltage was highly consistent and could be directly output in parallel without complex power electronics conversion.
Effects of Process Parameters on Bond Properties of Ag-2.35Au-0.7Pd-0.2Pt-0.1Cu Alloy Wire
Authors: Zhou Hongliang , Chang Andong , Cao Jun , Zhang Yingchong , An Bin , Xia Jie
Published: June 2023

Bond Properties were performed on Ag-2.35Au-0.7Pd-0.2Pt-0.1Cu alloy wire with a diameter of 25 µm under different process parameters. Effects of electrical flaming off (EFO) current and EFO time on deformability of the free air ball (FAB) were investigated using scanning electron microscopy (SEM) as well as the effects of ultrasonic power and bonding force on the bond characteristic. The experimental results showed that, FAB grows from a preheated tip to a small ball, a regular ball and finally to a golf ball with increasing either the EFO current or the EFO time, and the FAB presented optimal shape at 25 mA and 650 μs. Moreover, a nonlinear relationship between FAB diameter and EFO time is obtained at the EFO current of 25 mA, which could be expressed by a cubic equation. Further, at a constant bonding force, as the ultrasonic power increased, the mashed ball diameter grew larger and larger, the capillary hole imprint became more and more obvious, and the tail width also increased larger and larger, and vice versa. The optimal ultrasonic power and bonding force are 70 mW and of 45 gf for ball bond and 90 mW and 75 gf for wedge bond, respectively. Finally, for all the bonded wire samples prepared under optimal process parameters, no ball and wedge bond lifts happened after destructive pull test, and full intermetallic compound coverage with perfect morphology occurred on the bond pad after ball shear test, which meant that the bonded wire samples have high bond strength, and hence improved the reliability of microelectronic products.
Cyanoacrylate Glue for Treating Chronic Saphenous Vein Insufficiency: A Retrospective Observational Single-Center Study
Authors: Falvo Nicolas , Latreche Amine , Chevallier Olivier , Ledan Frédérik , Jandot Maud , Daoud Héla , Fréchier Léo , Loffroy Romaric
Published: June 2023

Endovenous thermal methods are superseding surgical stripping for treating chronic superficial venous disease but require tumescent anesthesia and can cause heat-related nerve injuries. Endovenous cyanoacrylate ablation is a more recent technique that does not share these drawbacks. Retrospective observational study of consecutive adults managed with endovenous cyanoacrylate in 2018–2021 at a single university center. Follow-up was 18 months. We identified factors associated with target vein closure at 18 months and measured changes in quality of life using the generic 36-item Short-Form tool (SF-36) and the venous disease-specific VEINES-QOL/Sym questionnaire. Adverse events were collected. In the 55 study patients with 67 treated veins, the closure rate at 18 months was 94% (95%CI, 85%–98%). Target vein diameter ≥9.5 mm had 81% sensitivity and 75% specificity for predicting recanalization. Both quality-of-life scores improved significantly (P<0.001 for both). The only adverse event was a type IV allergic reaction to cyanoacrylate that resolved with corticosteroid and histamine-antagonist therapy. Endovenous cyanoacrylate ablation was highly effective and safe in experienced hands. Studies are warranted to determine whether changes in the protocol increase the closure rate in patients with target veins ≥9.5 mm in diameter.
Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers
Authors: Rafikova Guzel , Gilyazova Irina , Enikeeva Kadriia , Pavlov Valentin , Kzhyshkowska Julia G.
Published: June 2023

Epidemiological data highlight prostate cancer as a significant global health issue, with high incidence and substantial impact on patients' quality of life. The prevalence of this disease is associated with various factors, including age, heredity, and race. Recent research in prostate cancer genetics has identified several genetic variants that may be associated with an increased risk of developing the disease. However, despite the significance of these findings, genetic markers for prostate cancer are not currently utilized in clinical practice as reliable indicators of the disease. In addition to genetics, epigenetic alterations also play a crucial role in prostate cancer development. Aberrant DNA methylation, changes in chromatin structure, and microRNA (miRNA) expression are major epigenetic events that influence oncogenesis. Existing markers for prostate cancer, such as prostate-specific antigen (PSA), have limitations in terms of sensitivity and specificity. The cost of testing, follow-up procedures, and treatment for false-positive results and overdiagnosis contributes to the overall healthcare expenditure. Improving the effectiveness of prostate cancer diagnosis and prognosis requires either narrowing the risk group by identifying new genetic factors or enhancing the sensitivity and specificity of existing markers. Immunological biomarkers (both circulating and intra-tumoral), including markers of immune response and immune dysfunction, represent a potentially useful area of research for enhancing the diagnosis and prognosis of prostate cancer. Our review emphasizes the need for developing novel immunological biomarkers to improve the diagnosis, prognosis, and management of prostate cancer. We highlight the most recent achievements in the identification of biomarkers provided by circulating monocytes and tumor-associated macrophages (TAMs). We highlight that monocytes-derived and TAMs-derived biomarkers can enable to establish the missing links between genetic predisposition, hormonal metabolism and immune responses in prostate cancer.
Landau Diamagnetism and de Haas van Alphen Oscillations in the Phase Separation Regions, Formed in Y3Fe5O12 Domain Walls, in the Strong Magnetic Fields at Room Temperature
Authors: Khannanov Boris , Golovenchits Evgenii , Scheglov Mikhail P. , Sanina V.A.
Published: June 2023

This paper presents results of the magnetic dynamics study (the microwave power absorptions at the fixed frequencies, during magnetic field sweeping) in samples of Y3Fe5O12 single crystals in the form of plates and spheres of various sizes, at frequencies exceeding 30 GHz, in magnetic fields up to 18 kOe, at room temperature and T=77 K. It was found, that in this case, the inhomogeneity’s of the magnetic state manifested itself in the Y3Fe5O12 samples in as 2D local phase separation regions. These 2D phase separation regions formed inside domain walls representing superlattices with size’s 700 – 900 Å. Landau diamagnetism or de Haas van Alphen oscillations observed in the 2D phase separation regions at room temperature and T=77 K, depending on the shape and size of the studied plates and spheres.
Decomposition and Modeling of the Situational Awareness of Unmanned Aerial Vehicle for Advanced Air Mobility
Authors: Kamkuimo Sorelle Audrey , Magalhaes Felipe , Zrelli Rim , Misson Henrique Amaral , Nicolescu And Gabriela , Nicolescu Gabriela
Published: June 2023

The use of unmanned aerial aircrafts (UAVs) is governed by strict regulatory frameworks that prioritize safety. To guarantee safety, it is necessary to acquire and maintain situational awareness (SA) throughout the operation. Existing Canadian regulations require pilots to operate their aircrafts in visual line-of-sight. Therefore, the task of acquiring and maintaining SA primary falls to the pilots. However, the development of aerial transport is entering a new era with the adoption of a highly dynamic and complex system known as advanced air mobility (AAM), which involves UAV operating autonomously beyond visual line-of-sight. SA must therefore be acquired and maintained primarily by each UAV through specific technologies and procedures. In this paper, we review these technologies and procedures in order to decompose the SA of the UAV in the AAM. We then use the system modeling language to provide a high-level structural and behavioral representation of the AAM as a system having UAV as its main entity. In a case study, we analyze one of the flagships UAVs of our industrial partner. Results show that this UAV doesn’t have all the technologies and methodologies necessary to achieve all the identified SA goals identified for the safety of the AAM. This work is a theoretical framework intended to contribute to the realization of the AAM, and we also expect to impact the future design and utilization of UAVs.
Renin-Angiotensin System Components and Arachidonic Acid Metabolites as Biomarkers of COVID-19
Authors: Ghimire Biwash , Khajehpour Sana , Middleton Elizabeth , Campbell Robert A , Nies Mary , Aghazadeh-Habashi Ali
Published: June 2023

Through the ACE2, a main enzyme of the renin-angiotensin system (RAS), the SARS-CoV2 gains access into the cell, resulting in different complications which may extend beyond the RAS and impact the Arachidonic Acid (ArA) pathway. The contribution of the RAS through ArA pathways metabolites in the pathogenesis of COVID-19 is unknown. We investigated whether RAS components and ArA metabolites can be considered biomarkers of COVID-19. We measured the plasma levels of RAS and ArA metabolites using an LC-MS/MS. Results indicate that Ang1-7 levels were significantly lower, whereas Ang II levels were higher in the COVID-19 patients than healthy control individuals. The ratio of Ang1-7/Ang II as an indicator of the RAS classical and protective arms balance was dramatically lower in COVID-19 patients. There was no significant increase in inflammatory 19-HETE and 20-HETE lev-els. The concentration of EETs was significantly increased in COVID-19 patients, whereas the DHETs concentration was repressed. Their plasma levels were correlated with Ang II concentration in COVID-19 patients. In conclusion, evaluating the RAS and ArA pathway biomarkers could provide helpful information for the early detection of high-risk groups, avoid delayed medical attention, facilitate resource allocation and improve patient clinical outcomes to prevent long COVID incidence.
Groundwater Contamination in Rural Communities and Its Potential Impact on Human Health
Authors: Mashau Funanani
Published: June 2023

Groundwater use for domestic and agricultural purposes is every day in rural communities. However, groundwater quality in those communities is still being determined due to the lack of water quality monitoring programs. The purpose of this study was to evaluate groundwater quality in rural communities using physiochemical parameters. Eight communities using communal boreholes were selected. Water samples were analysed for temperature, pH, electrical conductivity, total dissolved solids (TDS), ammonia, nitrate, and nitrite as Nitrogen. The pH means ranged from 6.6 to 8.1, whereas high TDS levels of 1390 mg/L and 1470 mg/L were observed in two boreholes. Three boreholes had higher electrical conductivity. Two boreholes had elevated nitrate levels of 15 and 21.5 mg/L. The high nitrate level correlates with the pH, EC, and TDS values. Our results suggest that high nitrate levels measured in communities’ boreholes pose ill health to the community, especially children, infants, and elders. Prenatal exposure to high nitrate has been found to have acute health effects in infants. Therefore, there is a need for further longitudinal studies on health risks among vulnerable groups in these communities.
Angular patterns of nonlinear emission in dye water droplets stimulated by femtosecond laser pulse for LiDAR application
Authors: Geints Yury E.
Published: June 2023

Femtosecond laser-induced fluorescence (FLIF) and femtosecond laser-induced optical breakdown spectroscopy (FIBS) are important tools for remote diagnostics of atmospheric aerosols using LiDAR techniques. They are based on light emission excitation in disperse medium via the multiphoton nonlinear processes in aerosol particles induced by high-power optical pulses. To date, the main challenge restraining the large-scale application of the FLIF and FIBS in atmospheric studies is the lack of valued theory of the stimulated light emission in liquid microparticles with sufficiently broad range of sizes. In this paper, we fill this gap and present the theoretical model of dye water droplets emission under high-intense laser exposure that adequately simulates the processes of multiphoton excited fluorescence and optical breakdown plasma emission in microparticles and gives quantitative estimates of the angular and power characteristics of the nonlinear emission. The model is based on the numerical solution to the inhomogeneous Helmholtz equations for the stimulating (primary) and nonlinear (secondary) waves provided by the random nature of molecule emission in particles. We show that droplet fluorescence stimulated by the multiphoton absorption generally becomes more intensive with increasing particle size. Moreover, far-field plasma emission from liquid particles demonstrates larger angular diversity when changing droplet radius in comparison with the multiphoton excited fluorescence, which is mainly due to the excitation of the internal optical field resonances in spherical particles.
Fungi in a One Health Perspective
Authors: Simões Daniela , De Andrade Eugénia , Sabino Raquel
Published: June 2023

Fungi constitute a diverse group with highly positive and negative impacts in different envi-ronments, having several natural roles and beneficial applications in human life, but also caus-ing several concerns. Fungi can affect human health directly, but also indirectly by being detri-mental for animal and plant health influencing food safety and security. Climate changes are al-so affecting fungal distribution, prevalence, and their impact on different settings. Searching for sustainable solutions to deal with these issues is challenging due to the complexity of the inter-actions among fungi and agriculture, animal production, environment, and human health. In this way, the “One Health” approach may be useful to get some answers since it recognizes that human health is closely connected to animal and plant health, as well as to the shared environ-ment. This review aims to explore and correlate each of those factors influencing human health in this “One Health” perspective.
Brain Injury Plasma Biomarkers in Patients on VA-ECMO: A Pilot Prospective Observational Study
Authors: Kapoor Shrey , Ahmad Syed Ameen , Muquit Siam , Gusdon Aaron , Khanduja Shivalika , Ziai Wendy , Everett Allen , Whitman Glenn , Cho Sung-Min
Published: June 2023

Background: Early diagnosis of acute brain injury (ABI) is critical for patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) to guide anticoagulation strategy; however, neurological assessment in ECMO is often limited by patient sedation. Methods: In this pilot study of adults from June 2018 to May 2019, plasma samples of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), and Tau were collected daily after VA-ECMO cannulation and measured using a multiplex platform. Primary outcomes were the occurrence of ABI, assessed clinically, and neurologic outcome, assessed by modified Rankin Scale (mRS). Results: Of 20 consented patients (median age=48.5 years; 55% female), 8 (40%) had ABI and 15 (75%) had unfavorable neurologic outcomes at discharge. 10 (50%) patients were centrally cannulated. The median duration on ECMO was 4.5 days (IQR: 2.5-9.5). Peak GFAP, NFL, and Tau levels were higher in patients with ABI vs. without (AUC = 0.77; 0.85; 0.57, respectively) and in patients with unfavorable vs. favorable neurologic outcomes (AUC = 0.64; 0.59; 0.73, respectively). GFAP elevated first, NFL elevated to the highest degree, and Tau showed limited change regardless of ABI. Conclusion: Plasma biomarkers may facilitate early detection of ABIs in VA-ECMO where neurological exam is limited and assist timely clinical decision-making.
Medical Radiology in Italy: Current Progress
Authors: Pepe Alessia , Crimì Filippo , Vernuccio Federica , Cabrelle Giulio , Lupi Amalia , Zanon Chiara , Gambato Sebastiano , Perazzolo Anna , Quaia Emilio
Published: June 2023

Recently, Medical Radiology has undergone significant improvements in patients’ management due to advancements in image acquisition by last generation machines, data processing, and integration of artificial intelligence. In this way, cardiovascular imaging is one of the fastest growing radiological subspecialty. A compressive review was focused on addressing how and why CT and MR have gained a I class indication in most cardiovascular diseases, and the potential impact of the tissue and functional characterization by CT photon counting, quantitative MR mapping, and 4-D flow.
Regarding rectal imaging, advances in cancer imaging by using diffusion-weighted MRI sequences for identifying residual disease after neoadjuvant chemoradiotherapy and [18F] FDG PET/MRI were provided for high-resolution anatomical and functional data in oncological patients. We offered a large overview on the approach to the imaging of diffuse and focal liver diseases by US elastography, contrast-enhanced US, quantitative MRI, and CT for the patient’s risk stratification. Italy is riding the wave of these improvements. The development of large networks will be crucial to create high-quality databases for a patient-centered precision medicine by artificial intelligence. dedicated radiologists with specific training and a close relationship with the referring clinicians will be the essential human factor.
KESESUAIAN PRINSIP RETALIASI DALAM KASUS PERANG PERDAGANGAN ANTARA AMERIKA SERIKAT DAN TIONGKOK
Authors: Savira Gina Nafsah
Published: June 2023

Penelitian ini menggambarkan dan meneliti masalah tentang apakah tindakan yang dilakukan oleh Amerika Serikat terhadap China atau sebaliknya sesuai dengan aturan pembalasan dalam perdagangan internasional. Penelitian ini adalah penelitian hukum normatif preskriptif. Data sekunder yang digunakan adalah bahan hukum primer, sekunder, dan tersier. Teknik pengumpulan data yang digunakan adalah penelitian kepustakaan, instrumen penelitian dalam bentuk Pemahaman Penyelesaian Sengketa,

Perjanjian Umum tentang Tarif dan Perdagangan, Perjanjian tentang Safeguards, AS-China Relation Act, kemudian analisis teknis yang digunakan adalah metode deduktif. Hasil penelitian menunjukkan bahwa kebijakan ekonomi yang dilakukan oleh AS disebut solusi perdagangan dalam bentuk proteksionisme yang mengacu pada tindakan pengamanan dalam kerangka hukum WTO. Solusi perdagangan bertujuan untuk meminimalkan dampak negatif impor pada produk dalam negeri. Selanjutnya, tindakan yang diambil oleh Tiongkok adalah salah satu contoh tindakan perbaikan dalam bentuk pembalasan.

 
A Stepper Motor-Powered Lower Limb Exoskeleton with Multiple Assistance Functions for Daily Use by the Elderly
Authors: Fang Yifan , Hou Bingkai , Wu Xiuyuan , Wang Yuntian , Osawa Keisuke , Tanaka Eiichiro
Published: June 2023

With the increase in the aging population, the demand for healthcare devices has increased. Among the aging population, many experience joint pain, muscle weakness, or poor balance. Without external help, such persons may have difficulty walking, fall easily, or experience poor quality of life. To provide this category of the population with the opportunity to exercise and walk safely and take care of themselves in daily activities, a stepper motor-powered walking assistive device is proposed and built. The device enables users with different heights to walk in suitable gaits; assists users to stand up, sit down, and step up or down stairs; automatically detects user’s intention using pressure sensors and potentiometers; and can be used outdoors for long periods. In this study, the effectiveness of the device is verified using muscle-activity measurements.
Gait Analysis and Improvement of Hexapod Mobile Robot Using Tetrahedral-Shaped Pneumatic Soft Actuators
Authors: Cho Feifei , Hase Kenta , Akagi Tetsuya , Dohta Shujiro , Shinohara Takashi , Yokota Masashi
Published: June 2023

In recent years, the aging of society has led to challenges such as ensuring adequate facility capacity and promoting health maintenance for the elderly. Consequently, there has been a growing demand for rehabilitation and fitness equipment suitable for use in limited spaces such as homes. In a previous study, a hexapod mobile robot, equipped with six tetrahedral-shaped pneumatic soft actuators (TSAs), was developed as a core training device to address these issues. However, the robot’s gait was investigated experimentally via a trial-and-error process. Hence, it is necessary to examine the stability of the gait. In this study, a straightforward model is presented for gait analysis of the mobile robot. Furthermore, the stability of the gait is demonstrated based on the analysis, and a more efficient gait with a sufficient stability margin is introduced.
Through-Hole Detection and Finger Insertion Planning as Preceding Motion for Hooking and Caging a Ring-Shaped Objects
Authors: Makihara Koshi , Otsubo Takuya , Makita Satoshi
Published: June 2023

This study investigated a pregrasp strategy for hooking and caging ring-shaped objects. Through-hole features enable the robot hand to hook an object with holes by inserting its finger into one of the holes. Compared to directly grasping the ring, an inserting motion is more convenient to allow the uncertainty of positioning errors and avoid collisions between the hand and the object. Instead of recognizing the exact shape of the object, we only detected its ring-shaped feature as a through-hole to be inserted and estimated its approximate center position and orientation from the point cloud of the object. The estimated geometric properties enabled the approaching motion of the robotic gripper to complete insertion. The proposed perception and motion-planning method was demonstrated for rigid and deformable objects with holes.