bluuebunny/crossref_metadata_2025 huggingface dataset:
Child-Friendly School and Its Relationship with the Merdeka Curriculum in Forming the Students' Character through Science Learning
Authors: Rusilowati A. , Hidayah I. , Nugrahani R. , Abidin Z. , Hutagalung F. D. , Sofchah T. , Ariyanti S. W.
Published: June 2024

The Merdeka Curriculum demands student competence and character formation through the Pancasila Student Profile (called P3). Through science learning, P3 indicators can be achieved. This study aims to (1) analyze Child-friendly School (CFS) implementation in SHS-X, (2) analyze SHS-X students' characters, and (3) identify teachers' attitudes during learning in SHS-X. This research uses a qualitative approach. The sample was obtained using purposive sampling from a child-friendly school implementing a Merdeka curriculum. The data validity was tested by triangulation. Data was explored based on participants' said, felt, and done or an emic perspective. Science learning activities inside and outside the classroom were observed. The subjects were principals, teachers, alumni, parents, and students at SHS-X. Data was collected through observation, interviews, analyzing documents, and giving questionnaires. Data analysis used the Miles and Huberman model. Based on the research and discussion results, implementing the child-friendly school policy at SHS-X has met the indicators set out in the Child-Friendly School Guidelines. The characters formed in SHS-X students include (1) nationalism, (2) religion, (3) leadership, (4) politeness, (5) honesty, (6) cooperation, and (7) anti-corruption. Another thing that makes SHS-X superior is that the teachers’ attitudes during learning are friendly, humane, and fun. With the two-way discussion method, learning becomes more interactive. With teachers teaching humanely, many students experience changes in behavior and learning outcomes. It is hoped that SHS-X's best practices in implementing CFS can inspire other schools.
Comparison of SWAT-based Ecohydrological Modeling in the Rawa Pening Catchment Area, Indonesia
Authors: Amalia A. V. , Fariz T. R. , Lutfiananda F. , Ihsan H. M. , Atunnisa R. , Jabbar A.
Published: June 2024

The Soil and Water Assessment Tool (SWAT) is an ecohydrological model widely applied to assess water quality and watershed management. This tool also has the advantage of building watershed models even with limited monitoring data availability. The essential data required by this tool includes digital elevation models (DEM), land use maps, climate data, and soil data. Nonetheless, the availability of spatial data is still often a challenge in developing hydrological models, especially in developing countries such as Indonesia. This research will compare the accuracy of freely available data in Indonesia in facilitating the development of hydrological models from SWAT in the Rawa Pening catchment area. This research is crucial since Rawa Pening Lake is a priority lake for revitalization, so the research results will help provide suggestions regarding presenting data in SWAT modeling. This research compares SWAT models built from different land use and DEM (Digital Elevation Models) data. The land use data being compared is the result of processing from the Google Earth Engine (GEE) platform using machine learning with land use data from government agencies, namely the Ministry of Environment and Forestry, while the DEM data being compared is SRTM and DEMNAS data. The validation results using R, R2, RMSE, and NSE show that, in general, the model built from land use from GEE is the best compared to the other models. In modeling SWAT in Indonesia, we recommend using good-quality land-use data. Utilizing supervised classification through Random Forest (RF) algorithms within GEE can facilitate the acquisition of this data. To reduce computation time, the DEM can be SRTM with a small sacrifice of accuracy.
The Influence of WE-ARe (Warm-Up, Exploring, Argumentation, Resume) Model Integrated with 21st-Century Skills on Prospective Biology Teachers' Communication Skills
Authors: Amin A. M. , Adiansyah R. , Mustami M. K. , Yani A. , Hujjatusnaini N. , Ahmed M. A.
Published: June 2024

The research aims to identify the influence of the WE-ARe (Warm-up, Exploring, Argumentation, Resume) model integrated with 21st-century skills on prospective biology teachers’ communication skills. The research type was quantitative, using a quasi-experiment research design. The research sample consisted of 60 biology education students in three classes. The research instruments used were valid and reliable observation sheets and questionnaires to measure communication skills. Data were analyzed using Covariate Analysis (ANCOVA) with a significant level of 5%. The research shows that the average communication in the experimental group after receiving treatment is 90.63, while in the positive control group, it is 73.54, and in the negative control group, it is 39.14. The test results to find out the difference in communication skills between the experimental and control groups obtained a calculated F value of 2846.491 with a significance value of 0.000. The significance value is smaller than the real level alpha 5% or (0.05). The research concludes that there is an influence of the WE-ARe model integrated with 21st-century skills on prospective biology teachers’ communication skills. The learning phases of the WE-ARe model integrated with 21st-century skills are proven to improve verbal and non-verbal communication skills. WE-ARe is a new learning model developed by researchers to accommodate the learning needs of students in the Industry 4.0 era towards the Society 5.0 era by using the principles of constructivism, collaborative, and participatory elaboration. The research is expected to contribute to increasing the global competence of university graduates, especially teachers.
The Professional Competency Development Model of Science Teachers through Learning Leadership
Authors: Utaminingsih S. , Sundari S. , Mirana A. E.
Published: June 2024

This research aims to analyze the model for developing the professional competence of science teachers through learning leadership. This method is quantitative research applied to a survey with a cross-sectional design. The participants were the science teachers at Pati residency, with 240 respondents. The researchers collected a questionnaire consisting of 46 validated questions with estimated reliability. The questions consisted of four teacher competence models and three leadership learning indicators. The researchers analyzed with the Structural Equation Modeling, SEM. Based on the data analysis, the science teacher competency development model is positively influenced by learning leadership by 15% in the small category. It also showed that the science teacher competency model formed from indicators of professional development and learning practices is in the large category, while professional knowledge and soft skills are in the moderate category. This research concluded that learning leadership contributed little to the science teacher competency development model. In the era of independent learning, it was important for school principals to increase the development of professional competency models for science teachers so that they can implement student-centered learning. The results of these findings provided input to school principals to improve their leadership in managing teacher learning, starting from planning, learning processes, evaluation, and reflection, while science teachers to improve their professional competence through learning activities with lesson studies and research actions as well as activities outside of learning such as training and seminars.
Digital Problem-Based Worksheet with 3D Pageflip: An Effort to Address Concept Understanding Problems and Enhance Digital Literacy Skills
Authors: Distrik I. W. , Ertikanto C. , Purwati Y. S. , Saregar A. , Ab Rahman N. F.
Published: June 2024

This study aims to provide digital teaching materials in the form of problem-based worksheets with 3D PageFlip presentations that are valid, practical, and effective in overcoming conceptual understanding problems and enhancing digital literacy skills in high school students. The research approach employed was a mixed method based on Thiagarajan’s (1974) 4D development model, which consists of four stages: define, design, develop, and disseminate. Three experts conducted the validity test and a limited field test involving ten high school students. Furthermore, the large-scale field test was carried out at another high school with 60 students utilizing the static pretest-post-test design. Data for the study were gathered through observation, tests, and questionnaires. Qualitative data analysis was done descriptively using the percentage technique, while quantitative data was analyzed using statistical tests. According to the results, the problem-based digital worksheet with the 3D PageFlip display has an average content validity of 8.83 and an average construct validity of 8.91. It has been proven practical with a digital worksheet implementation rate of 89.39 and positive student responses. Conceptual understanding that occurs before learning can be overcome through images and videos embedded in digital worksheets. The difference in concept knowledge and digital literacy progress between the experimental and control groups demonstrates the usefulness of this teaching material. Thus, problem-based digital worksheet teaching materials with 3D PageFlip can overcome conceptual understanding problems and improve students’ digital literacy.
Del androcentrismo hacia un nuevo enfoque de la transversalización de la perspectiva de género a través de la Corte Interamericana
Authors: Estrada Vargas Eduardo A
Published: June 2024

The primary goal of this research is to introduce a new approach to mainstreaming gender perspective, which includes not only women and girls but also the lesbian, gay, bisexual, transgender, and intersex (LGBTI) population. The study begins by examining the androcentric view of society, which has fostered its heteronormativity and patriarchal system. It then explores the evolution of the concepts of gender perspective and gender identity. Finally, the analysis evaluates judgments and advisory opinions issued by the Inter-American Court of Human Rights (IACHR) on matters concerning non-discrimination, sexual orientation, family, work, and equal protection under the law. These legal decisions establish reparative actions to safeguard and advance the rights of vulnerable groups. The study also aims to underscore the reparative measures concerning non-repetition guarantees, which the Inter-American Court advocates to promote mechanisms and public policies that States must adopt to overcome barriers of discrimination and social stigma that continue to impact Latin American societies.
Una lucha contra las violaciones de los derechos humanos en Guapinol, Honduras: la metodología feminista decolonial en las narrativas de resistencia
Authors: Sullivan Kathryn
Published: June 2024

This article addresses the flagrant human rights violations in Guapinol, Honduras, between 2018-2022, emphasizing the decolonial feminist methodology used in a participatory action investigation. In recent years, the region has witnessed numerous human rights violations, especially related to the defense of the Guapinol River against the mining company Inversiones Los Pinares. The main objective of this article is to explore the methodology employed in the collection of the resistance narratives of five women who are all relatives of the "Guapinol Eight," the water defenders who were imprisoned for their defense of the river. Adopting a human rights perspective, the decolonial feminist methodology revealed the crucial contribution of women in resistance, providing a comprehensive methodological map for understanding the dynamics of oppression, intimidation and violence imposed by Inversiones Los Pinares. The results underscore the essential role of women in the struggle against human rights violations. The article concludes by highlighting the importance of sharing the methodology used, not only as an analysis of the violations in Guapinol, but also as a call for the continued collection and sharing of stories of resistance. The author hopes that this approach will inspire future research that gives voice to the experiences of resistors and promotes social justice.
Study on optical properties of hexagonal lattice photonic	crystal fibers infiltrated with heavy	water
Authors: Dang Van Trong , Le Tran Bao Tran , Chu Van Lanh
Published: June 2024

In this paper, we analyzed a PCF made from fused silica glass, with a core filled with heavy water. The guiding properties of proposed fibers in terms of effective refractive index, attenuation, and dispersion of the fundamental mode were studied and optimized setups were selected and analyzed in detail. After 25 simulations, we determined two structures possessing optimal dispersion with the lattice constant (Ʌ) and the filling factor as follows: Ʌ = 1.1 µm, d/Ʌ = 0.92 for #F1 and Ʌ = 1.4 µm, d/Ʌ = 0.92 for #F2. Besides, high nonlinearity and low confinement loss are also outstanding points in our model. Thanks to these advantages, the proposed fibers have been targeted for flat and smooth broadband supercontinuum (SC) generation for near-infrared applications.
Epicardial fat thickness as a component of early vascular aging in patients with coronary artery disease with borderline coronary stenosis
Authors: Yakhontov D. A. , Ostanina Ju. O. , Lukinov V. L.
Published: June 2024

Aim. To evaluate the incidence of early vascular aging (EVA) and epicardial fat thickness (EFT) in patients with stable coronary artery disease (CAD) with borderline stenosis.

Material and methods. The study involved 201 patients with class 1-3 stable CAD with borderline (50-70%) stenosis. The first group consisted of 57 (28,4%) patients with increased EFT, the second (n=144 (71,6%)) — without increased EFT. EFT was determined by cardiac ultrasound. Vascular wall stiffness was assessed using a VaSera VS-1500N sphygmomanometer manufactured by FUKUDA DENSHI (Japan). Relative telomere length was determined by real-time PCR. All patients underwent coronary angiography.

Results. The mean EFT in group 1 was 6,00 [5,00; 6,50] mm, in group 2 — 3,00 [2,30; 4,00] mm (p<0,001). In patients of group 1, hypertension (p<0,001), CAD (p<0,001) in general and myocardial infarction (p=0,003) in particular debuted at a younger age. In both groups, the incidence of obesity, type 2 diabetes, angina, and the intake rate of all four main groups of antianginal drugs did not differ significantly. Early vascular aging was significantly more often detected in the group of patients with stable CAD with borderline coronary artery stenosis and visceral obesity (p<0,001). Relative telomere length was shorter and pulse wave velocity was higher in this group (p<0,001).

Conclusion. Patients with stable CAD with borderline stenosis and increased EFT have a higher incidence of EVA, despite the same incidence of obesity, diabetes, and functional class of angina as the group of patients without increased EFT.
Biomarkers of fibrosis and inflammation and the risk of arrhythmia recurrence after elective electrical cardioversion in patients with atrial fibrillation and metabolic syndrome
Authors: Barashkova E. I. , Ionin V. A. , Baranova E. I.
Published: June 2024

Aim. To evaluate the effect of blood concentrations of biomarkers of inflammation and fibrosis, obesity parameters, and parameters characterizing cardiac remodeling on the risk of recurrent atrial fibrillation (AF) within 6 months after elective electrical cardioversion (ECV) in patients with metabolic syndrome (MS).

Materials and methods. The study included patients with AF and MS (n=60) and with AF without MS (n=41), who underwent elective ECV. Prospective observation was carried out for 6 months.

Results. Arrhythmia recurrence within 6 months after ECV in patients with AF in combination with MS is higher than without MS (34/60 and 9/41, p = 0.003). Among echocardiographic parameters, left atrial volume and volume index, and epicardial adipose tissue thickness (EAT) are associated with arrhythmia resumption in patients with MS and AF. Blood concentrations of galectin-3 (17.4 (12.8-19.6) and 13.3 (5.1-14.9), p=0.0001), connective tissue growth factor (CTGF) (163, 1 (134.1-232.2) and 156.7 (104.7 - 189.1), p=0.002), growth differentiation factor 15 (GDF-15) (2343.9 (1206.1-3254.2 ) and 986.1 (812.5-1775.5), p=0.0001) and interleukin-6 (IL-6) (3.8 (2.3-7.3) and 2.3 (1, 3-3.4), p=0001) in patients with MS with recurrent arrhythmia is higher than without arrhythmia. According to the ROC analysis of EAT, the concentration of galectin-3 and IL-6 in the blood was most predictive of relapse of AF in MS; threshold values of the predictors were established: EAT more than 6.1 mm, IL-6 more than 2.8 pg/ml, galectin-3 more than 15.9 ng/ml.

Conclusion. In patients with AF combined with MS, the frequency of maintaining sinus rhythm after effective ECV for 6 months is lower than in patients without MS. Epicardial adipose tissue thickness, high concentrations of galectin-3 and IL-6 are associated with relapse of AF in patients with MS.
Masked uncontrolled hypertension in patients with impaired carbohydrate metabolism
Authors: Nazarova V. V. , Antropova O. N. , Osipova I. V. , Zhuravleva A. N. , Semenova M. I.
Published: June 2024

Aim. To establish the prevalence of masked uncontrolled hypertension (HTN) (MUH) in patients with diabetes or impaired glucose tolerance (IGT) and determine its clinical and hemodynamic characteristics.

Material and methods. The study involved 87 patients who received regular antihypertensive therapy for hypertension and had established diabetes or IGT. The mean age of patients was 62,6±9,9 years, of which 51,7% were women, 48,3% — men. Type 2 diabetes was revealed in 77,7%, IGT — 22,8% of patients. For 24-hour blood pressure monitoring, BpLAB system (OOO Petr Telegin) was used; blood pressure (BP) was determined in the brachial artery, central blood pressure — in the aorta. We analyzed risk factors and target organ damage. The results were processed using the Excel Microsoft Office 2007 package and the Statistica 6.0 and 10.0 package from StatSoft, Inc (USA).

Results. Uncontrolled hypertension was revealed in 59,8%, MUH — in 18,4%, controlled HTN — 21,8% of patients. Mean daytime and mean nighttime systolic BP in patients with MUH and uncontrolled HTN were comparable. Patients with controlled hypertension compared with MUH had lower mean day- and nighttime aortic BP by 27,1% (p<0,01) and 16,8% (p<0,01), respectively. Aortic BP was comparable in individuals with MUH and uncontrolled HTN. Asymptomatic hyperuricemia was more common in patients with uncontrolled HTN compared with MUH and controlled hypertension by 29,3% and 41,8%, respectively. With MUH, compared with controlled HTN, we revealed a higher incidence of stroke by 18,8%, a decrease in glomerular filtration rate <60 ml/min by 17,5%, albuminuria by 18,8%, left ventricular hypertrophy by 2,6 times.

Conclusion. Only 41,2% of patients with diabetes and prediabetes achieve the target office BP level, while every second of these patients has MUH. MUH, compared with controlled HTN, is characterized by a higher incidence of stroke, kidney (decrease in glomerular filtration rate <60 ml/min and albuminuria) and heart damage (left ventricular hypertrophy).
Non-alcoholic fatty liver disease and ultrasound markers of obesity as unfavorable factors in the course of coronary artery disease
Authors: Tsygankov D. A. , Polikutina O. M.
Published: June 2024

Aim. To evaluate the association of non-alcoholic fatty liver disease (NAFLD) with markers of visceral obesity in patients with coronary artery disease (CAD).

Material and methods. We examined 125 patients hospitalized in the emergency cardiology department with CAD (female — 41,6%, male — 58,4%) and body mass index of 18,5-35,0 kg/m2. The median age of the subjects was 68 [61,0;74,0] years. We assessed following ultrasound parameters of visceral obesity: intraabdominal fat thickness (IAFT), abdominal wall fat index (WFI), preperitoneal fat thickness (PFT), subcutaneous adipose tissue (SAT), represented by MinSAT and MaxSAT. The following liver parameters were assessed: anteroposterior dimension of the left lobe and oblique-vertical dimension of the right lobe. Statistical data processing was carried out using the Statistica 6.0 program. Quantitative variables are presented as median (Me). Percentiles (25%; 75%) were used as dispersion measures. The influence of several predictors was assessed using linear regression analysis.

Results. In patients without echographic signs of hepatic steatosis, the IAFT was 50,5 [30,7;65,0] mm and significantly increased with increasing hepatosis degree: from 45,0 [24,0;63,0] mm in respondents with grade 1 to 67,5 [34,0;76,0] mm with grade 3 (p=0,010). PFT also significantly increased from 11,5 [8,9;13,3] mm in individuals without hepatic steatosis to 13,8 [10,7;15,6] mm in those with grade 1, 18,5 [13,0;22,4] mm in those with grade 2 and 23,5 [13,0;29,4] mm in those with grade 3 hepatic steatosis (p=0,001). MinSAT and MaxSAT also increased, but not significantly (from 11,5 [8,8;15,9] to 20,4 [10,1;27,3] mm, p=0,151 and from 14,0 [11,4;25,4] mm to 22,4 [15,0;25,0] mm, p=0,576, respectively). The increase in WFI was also not significant. Linear regression analysis confirmed that hepatic steatosis was associated with IAFT increase (b=9,3, p=0,012).

Conclusion. NAFLD is associated with factors influencing the CAD course — hyperglycemia, lipid metabolism disorders, as well as ultrasound markers of obesity. An increase in liver size was associated with an increase in BMI, glucose, triglycerides, high-density lipoproteins and ultrasound markers of obesity — IAFT and PFT. NAFLD in patients with CAD was associated with increased IAFT and PFT. In addition, 52,5% of people with normal body weight had NAFLD, which once again indicates the ineffectiveness of this indicator for stratifying the risk of development and progression of cardiovascular disease and the need for routine screening of NAFLD in people with cardiovascular diseases, regardless of BMI.
Bernard, Seth, Lisa Marie Mignone and Dan-el Padilla Peralta (eds). 2023. Making the Middle Republic. New Approaches to Rome and Italy, c. 400–200 BCE. Cambridge: Cambridge University Press; 978-1-009-32798-5 hardback $130.
Authors: Tol Gijs Willem
Published: June 2024

This is a review of Making the Middle Republic. New Approaches to Rome and Italy, c. 400–200 BCE, edited by Seth Bernard, Lisa Marie Mignone and Dan-el Padilla Peralta, published in 2023 by Cambridge University Press.
Kente Karşı İşlenen Suçlar Bağlamında Grand İsias Otel Örneği: Otellerin Güvenliğini Yeniden Düşünmek
Authors: Toker Arzu , Unat Rümeysa
Published: June 2024

Türkiye’de büyük kayıplara yol açan Kahramanmaraş depreminde çöken yüzlerce bina, binlerce insanın ölmesine neden olmuştur. Adıyaman’da yıkılan binalar arasında şehrin en büyük oteli Grand İsias Otel’in de olması gözleri konuklarına mezar olan otellere çevirmiştir. Depremde yıkılan tek otel olmasa da Türkiye eğitim gezisinde olan turist rehberi adayları ile KKTC’li çocuk voleybolcuların bu enkazda ölmesi Grand İsias Otel’i, mezar otellerin sembolü hâline getirmiştir. Bu araştırmada kentlere karşı işlenen suçlar bağlamında ele alınabilecek suistimallerin; Grand İsias Otel örneğinden yola çıkarak Kahramanmaraş depreminde yıkılan tüm otellerin durumunu, hataların çerçevesini ve turizm medyası yoluyla kamuoyunda nasıl temsil edildiğini ortaya koymak amacıyla nitel araştırma yaklaşımlarından durum çalışması benimsenmiştir. Araştırmanın verilerini, turizm medyasının en çok okunan beş platformunda yayımlanan depremde yıkılan oteller ile ilgili 156 haber metni oluşturmuştur. Haber metinleri nitel veri analiz programı aracılığıyla analiz edilmiştir. Analizler sonucunda ilgili haberlerin, yıkılan otellerin temsiliyeti, enkaz altındakilerin temsiliyeti, Grand İsias Otel’in mezar otel olarak sembolleşmesi ve deprem sonrası çağrışımlar ile ilgili bulgular elde edilmiştir.
A strategy to optimize soil phosphorus reserve: A study based on native maize of Mexico and genotype selection
Authors: Salazar Mejía Selene Guadalupe , Bayuelo Jiménez Jeannette S.
Published: June 2024

Continual removal of phosphorus (P) by the crop gradually decreases soil fertility and drives the need for fertilizer inputs for agricultural production. Phytate is considered as the major storage pool for P in the seeds, but its contribution to human nutrition is low. The objective of this study was to characterize quantitative P concentrations (phytate, inorganic P and total P) of 50 native maize genotypes of Zea mays L. of the Patzcuaro lake, Michoacan, Mexico. The average total P and phytate concentration observed across all the genotypes was 3,1, 2,64, and 0,43 mg g-1, respectively. The relationship between phytate and total P was strong (r= 0,98**). This clearly suggests that with an increase in total P there is a corresponding increase in phytate concentration. Cluster analysis of data indicated five distinct groups with 1, 14, 11, 15 and 9 genotypes, respectively. Clusters I and II contained low phytate genotypes (1,74 mg g-1) while cluster V grouped most of the high phytate (4,9 mg g-1) contenting genotypes. Principal component analysis and F test showed the attributes more influencing group separation. Those attributes were total P and phytate. The first two components explained the 95% of the accumulation variation among groups. The race of the genotypes, however, was no clearly related to the group differentiation. These observations provide the first study on the genetic variety for breeding maize with lower P concentration to reduce P extraction from maize field at harvest.
Husref Tahirović: Dr. Isak Samokovlija. The life in a white coat
Authors: Damjanov Ivan
Published: June 2024

Dr. Husref Tahirović, an endocrinologist and professor emeritus of pediatrics at the University of Tuzla School of Medicine and a member of the Academy of Sciences and Arts of Bosnia and Herzegovina, performed many functions and held many appointments during his long professional life, reflecting his various scientific and social interests. Among other roles, he has been the Editor-in-Chief of Acta Medica Academica, the official journal of the Academy. In this journal, he published several historical articles on famous physicians from Bosnia and Herzegovina. His interest in history also led him to spend considerable time during the last few years researching the life and works of Dr. Isak Samokovlija a celebrated writer in former Yugoslavia, who was also a physician recognized for his contributions to medicine and the organization of health care services in Bosnia and Herzegovina before the Second World War. This book contains a wealth of data that Dr. Tahirović has collected about this remarkable physician, who was born in Goražde in 1889 and died in Sarajevo in 1955.
Read more in the PDF.
Климатический дискурс в России: от дихотомии климатического сознания к четырем формам климатической политики
Authors: Лобанов Михаил Михайлович , Звезданович Лобанова Елена , Звезданович Милан
Published: June 2024

В статье рассматриваются особенности климатического дискурса в России, развивающегося в условиях усиления глобальных рисков изменения климата. Участниками дискурса выступают как ученые, чиновники и предприниматели, так и представители других общественных страт, балансирующие между двумя крайними формами климатического сознания – климатическим скептицизмом и алармизмом. В соответствии с оценкой климатических вызовов формируется отношение к государственной климатической политике, направленной на устранение или адаптацию к возникающим угрозам. Анализ сложившихся в обществе позиций позволил выделить четыре подхода к государственной климатической политике. Укорененность идей климатического скептицизма обуславливает высокий уровень неприятия климатической политики в российском обществе (отрицательное влияние на хозяйственную динамику, неэффективность мер, кабальные условия международных соглашений по декарбонизации). Напротив, поддержка теории антропогенного изменения климата отличает сторонников активной климатической политики, основанной на внедрении принципов «зеленого перехода» и формировании циркулярной экономики, стремлении к углеродной нейтральности за счет действия мер углеродного регулирования, технологической модернизации энергетики и промышленных производств, выпускающих продукцию с высоким углеродным следом (чугун и сталь, алюминий, цемент, аммиак и т. д.). Однако опыт реализации программ низкоуглеродного развития в России показывает, что декларируемые цели идут вразрез с задачами экономической безопасности, которые государственные органы считают приоритетными в условиях сырьевой модели развития (например, меры по сокращению эмиссии парниковых газов не должны ограничивать хозяйственный потенциал страны и влиять на конкурентоспособность ключевых отраслей). Третий подход, названный нами дифференцированной климатической политикой, предполагает учитывать как отрицательные, так и положительные эффекты глобального потепления. В зависимости от типа экологических рисков для определенных территорий должны разрабатываться селективные меры климатической политики. Наконец, четвертый подход заключается в отказе от стратегии низкоуглеродного развития в пользу адаптации населения и экономики к изменениям климата. Особенности каждого из четырех подходов подробно проанализированы в работе.
Феномен отложенного материнства и вспомогательные репродуктивные технологии: социально-экономические и демографические аспекты
Authors: Спиридонов Дмитрий Владимирович , Полякова Ирина Геннадьевна
Published: June 2024

В статье анализируются проблемы позднего (отложенного) материнства в современной России, а также готовности женщин к использованию технологий репродуктивного донорства. Результаты исследования, опирающегося на эмпирические данные, подтверждают тренд на постарение материнства, который фиксируется в России с конца 1990-х  годов, при этом выявляются некоторые корреляции между репродуктивными намерениями и социально-демографическими характеристиками разных групп женщин. Показаны различия в отношении к вспомогательным репродуктивным технологиям (ВРТ) у женщин в  возрасте 18–35 лет, а также различия в готовности стать донором биологического материала. Исследование позволило реконструировать три социальных портрета женщин в зависимости от их репродуктивных намерений, отношения к ВРТ и репродуктивному донорству, коррелирующие с уровнем образования и социальным статусом респонденток. В статье рассматривается вопрос о роли ВРТ в решении демографической проблемы постарения материнства и, как следствие, роста показателей окончательной бездетности. Анализ зарубежного опыта показывает, что независимо от доступности ВРТ в конкретной стране их применение не является значимым фактором, препятствующим снижению рождаемости. Тем не менее в условиях меняющейся возрастной модели материнства использование ВРТ следует рассматривать не столько как способ повышения рождаемости, сколько как инструмент ее поддержания и механизм компенсации количества естественных рождений за счет мобилизации женщин более старших возрастных групп, чье репродуктивное поведение ранее в принципе не оказывало никакого значимого влияния на общие демографические показатели. Отмечается, что, в отличие от многих западных стран, в  России потенциал использования ВРТ как инструмента поддержания рождаемости в  более старших возрастных группах остается достаточно значимым, однако он ограничивается идеологическими рамками государственной политики в области демографии.
The expression of DLGAP5 associate with progression and prognosis in glioma
Authors: Kangjie Du , Yu Zhang , Mengyao He , Yalin Lu , Xingjie Chen , Hao Yu , Qiang Huang
Published: June 2024

Glioma is the most common primary malignant tumor of the central nervous system and is related to poor clinical outcomes. At present, the standard treatment of glioma in clinical practice is to maximally remove the focus on the premise of protecting the neurological function, supplemented by postoperative chemotherapy and radiotherapy. However, after standard treatment, the prognosis of glioma patients is still not satisfactory. DLGAP5 has been shown to play an important role in the occurrence and progression of various tumors. This study examined the expression of DLGAP5 in glioma samples and its significance in predicting the prognosis of glioma patients. TCGA and CGGA datasets were used to explore the difference in DLGAP5 expression between glioma and normal central nervous system tissues and to investigate the prognostic value of DLGAP5 expression in glioma patients. The cBioPortal online analysis website was used to explore the gene mutations of DLGAP5 expressing in glioma. The String database and GEPIA online analysis website were used to perform Enrichment Analysis to explore the molecular mechanism of DLGAP5.In this study, we observed that DLGAP5 expression was upregulated in glioma tissues compared with normal CNS tissues and was negatively associated with the prognosis of glioma patients. DLGAP5 may affect the occurrence and progression of glioma mainly through gene mutation, gene amplification, and gene depth deletion. At the same time, the molecular inhibition of DLGAP5 may be related to the cell cycle and the p53 pathway. In conclusion, our findings suggested that DLGAP5 may be a therapeutic target and an independent prognostic indicator for glioma.
Remembering the dead, reconciling the living:
Authors: Belcher Kimberly Hope
Published: June 2024

Rituals advancing reconciliation often do so by recalling a shared history or proposing a shared future. Racial reconciliation in the United States and recovery from the clergy sexual abuse crisis must reckon with how the past can be justly remembered. The George Floyd Global Memorial in Minneapolis, Minnesota, occupies a space of remembrance, raising up a representative victim of police violence as a symbolic ancestor. The All Saints’ and All Souls’ Day monastic liturgies at St John’s Abbey in Collegeville, Minnesota, remember the dead and a future that transcends contemporary divisions. This article will explore how gestures toward an eschatological future in both of these memorial rites frame the memory of the past and mediate the relationship between the living and the dead amid a fragile movement towards reconciliation.
МONGOLIA:HOW TO EXIST AT THE CROSSROADS BETWEEN CHINA AND THE RUSSIAN FEDERATION?
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Ignatiev P.
Published: June 2024

It is widely known that in historic respect Mongolia became the only country that succeeded in times of Genghis Khan and his successors in the conquest of both China and huge lands of Slavic people. With the flow of time enormous Mongol Empire disintegrated and the state actor that was established in the place of it is forced to exist between former parts of the Empire that today belong to the list of the most powerful countries of the world in military and economic respects. The Mongolian foreign policy of balancing between China and the Russian Federation is very interesting topic of scientific research, since the study of it helps to understand the set of measures that allow relatively weak and isolated country preserving independence in such challenging geopolitical neighborhood.
A Review of Nanofluid Boiling Heat Transfer and Its Applications in Heat Pipes
Authors:   School of Mechanical Engineering, North China University of Water Resources and Electric Power, Zhengzhou, Henan 450045, CHINA, Wang Xinyu , Li Ya
Published: June 2024

Nanofluid is a new type of heat transfer medium formed by adding metal or non-metal in liquid medium in a certain proportion and manner, which has many advantages over the traditional working fluid. Combining heat pipes with nanofluids and using nanofluids as the working material of heat pipes can reduce thermal resistance and effectively improve the heat transfer performance of heat pipes. This paper provides a relevant overview of heat pipes and nanofluids, and introduces the relevant classifications of heat pipes, the working principle and the relevant research on nanofluid-enhanced boiling heat transfer. It conducts a literature review on the application of nanofluids in heat pipes, and finally proposes possible future research directions.
The Effect of Internet Development on Indonesia’s Agri-Food Export Potential in the Global Market
Authors: Suroso Arif Imam , Fahmi Idqan , Tandra Hansen , Haryono Adi
Published: June 2024

The Internet has become essential in increasing output between corporate and country levels. However, the impact of the Internet on trading potential still needs to be known. On the other hand, Indonesia has great potential to export agricultural food products in global trade. Therefore, the relationship between the Internet development and agri-food export potential could be explored. This study aims to investigate the effect of Internet development on Indonesia’s export potential in the global market. The export potential estimation was measured using gravity estimation in 124 destination countries from 2010 to 2020. Furthermore, the panel regression was employed to determine the three indicators of Internet development: Internet users, secure Internet servers, and fixed broadband subscriptions on Indonesia’s agricultural export potential. This study also utilized simulation due to the possibility of rising the number of Internet indicators. The results revealed several positive factors of Indonesia’s agricultural exports, such as importers’ gross domestic bruto (GDP), contagious border, and colonial relationship. Otherwise, geographical distance, exchange rate, and being a landlocked country negatively affected Indonesia’s agricultural exports. Indonesia possessed a greater potential for agricultural exports in Europe, especially in the conditions of emerging and developing economies. There were 85 destination countries with higher potential for Indonesia’s agri-food export. Additionally, Internet users and secure Internet servers positively influenced the agricultural export potential to target countries. The simulation revealed that improving Internet indicators boosted the new market rather than raising the export value to target countries.
Rare case of immune mediated cutaneous leucoclastic vasculitis with pancytopenia in a rheumatoid arthritis patient with chronic cytomegalovirus infection
Authors: Bajpai Rashmi Gupta , Garg Ayush
Published: June 2024

Acute febrile illnesses with systemic involvement can present significant diagnostic and therapeutic challenges, particularly in patients with multiple comorbidities. This case report highlights a complex presentation of acute febrile illness with pancytopenia and immune-mediated cutaneous vasculitis in a patient with type II diabetes mellitus. A 52-year-old male with a known history of type II diabetes mellitus presented with fever, decreased oral intake, loose stools, oral ulcers, dysphagia, and rashes over the trunk and abdomen for four days. Upon admission to the ICU, extensive diagnostic evaluations were performed, revealing significant hematological, biochemical, and serological abnormalities. Imaging studies and histopathological examinations were conducted to further investigate the underlying etiology. Laboratory findings indicated pancytopenia, acute kidney injury, and hyperkalemia. Infectious disease workup was largely negative, except for a positive CMV IgG. Imaging studies revealed medical renal disease, and a skin punch biopsy confirmed cutaneous leukocytoclastic vasculitis. Bone marrow biopsy suggested bone marrow suppression. Multidisciplinary management, including dialysis, IV fluids, antibiotics, blood transfusions, steroids, and Ganciclovir, led to the patient’s gradual improvement and stabilization. The comprehensive diagnostic and therapeutic approach in this case underscores the importance of considering immune-mediated etiologies in patients with atypical presentations. Multidisciplinary collaboration was crucial in managing the multifaceted clinical condition of the patient. Early recognition and prompt multidisciplinary management are essential in similar cases. Extensive diagnostic evaluations should be performed to identify the underlying causes, and immune-mediated etiologies should be considered in complex presentations. Further research is recommended to explore optimal management strategies for such multifaceted conditions.
A systematic review on the impact of interventions on gene expression profiles of rheumatoid arthritis patients
Authors: Shaham N Muhammad , Das Partha Pratim , Haque M Ijasul , Khanna Manish
Published: June 2024

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease with a poorly known aetiology. Although the primary characteristic of RA is inflammation, other biological systems are implicated in various phases of the disease. Interventions and their impact on gene expression in active RA patients is currently playing a significant role in the development of specific treat to target techniques. The present study aims toevaluate the effect of various reported interventions on gene expression in rheumatoid arthritis patients. Publicly available English databases, PubMed and Google Scholar, were queried from 2020 to 2023. We mined a total of 1970 research documents, of which 8 articles were selected based on the inclusion and exclusion criteria. The review analyzed therapeutics, including anti-TNF alpha-blockers, GM-CSF blockers, Chemokine receptor blockers and herbal Ginger in RA treatment and prediction of responders and non-responders based on gene expression analysis. However, due to the mixed-use of samples, experimental methodologies, analysis tools and genes studied in the studies, our comparison is inconclusive in determining effective therapy. The study highlights the necessity of harmonization in order for gene expression profiles to be effectively used as a clinical tool in RA patients' personalized medication.
Functional outcome of chronic osteomyelitis treated by sequestrectomy & saucerisation with antibiotic bead implantation
Authors: Jha Vikash Kumar , Zacarias Tomin P , Bharali Kaushik , Dutta Swapnaneel
Published: June 2024

Chronic Osteomyelitis has been treated since inception of Orthopaedics, however a ideal treatment eliminating the disease doesn’t exist. Numerous treatment modalities & Surgical procedures have been tried with varied results, owing to the chronic nature of the infection, virulence of organism and complex pathogenesis. With time, the antibiotic delivery to target site has expanded to include effective oral agents and local therapy with antibiotics mixed in bone cement or use of biodegradable antibiotic impregnated materials.

This study intends to obtain factors which influence the incidence of osteomyelitis in the population & also to know the common means of transmission of bony infection, further identification of the major areas of disease manifestations and means of eradication of the same by our procedure. We conducted a prospective randomized control study on patients diagnosed with chronic osteomyelitis in the age group of 4- 60 years. 30 patients were treated with sequestrectomy and saucerisation & dead space filling with biodegradable antibiotic impregnated calcium sulphate beads for local delivery of antibiotics. The calcium sulfate used in this study was The STIMULAN KIT. This bone void filler kit consists of surgical-grade calcium sulfate powder and a sodium chloride diluent with Vancomycin as the broad spectrum antibiotic.

: Functional outcome was evaluated using Enneking Functional Evaluation System which is a 30 point system for both upper and lower limbs. X-rays were used to evaluate the dead space volume (in cc) and bone repair (in %). Each patients were followed up for minimum of six months. The mean score for functional outcome was found to be 29.93. In 18 patients osteomyelitis occurred by hematogenous spread (60%) by superficial skin infection, Mean age of 13 patients (43.3%) were in the age group of 4-10 years. 63.3% of affected individuals were male. Most common site of infection was found to be tibia (33.3%) & most of the culture report from infection site showed no growth(90%). Complications such as prolonged ooze was seen in 15.9% cases. On Statistical analysis of the functional outcome, p value was found to be significant < 0.001.

Antibiotics containing beads (Stimulan Kit) is effective in the treatment of chronic osteomyelitis and in preventing the recurrence of infection. It is imperative to identify various factors responsible for the recurrence of infection. This may help clinicians predict the prognosis of the disease and minimise the risk of adverse outcomes.
A study of risk factors for Pott’s disease
Authors: Katkar Minish Raghunath , Chandanwale Ajay , Zad Shreyas , Deshpande Sandeep , Mangwalkar Vishal Anand
Published: June 2024

Pott’s spine is caused by Mycobacterium tuberculosis, a slow growing gram-positive, acid-fast bacillus which becomes lodged in the bone via Batson’s venous plexus and lymphatic from primarily infected lung, lymph nodes, mediastinum and viscera, forming granulomatous inflammation and caseation necrosis. Pott's spine accounts for 2% of all cases of TB, 15% of extrapulmonary, and 50% of skeletal TB. The paradiscal, central, anterior subligamentous, and neural arch are the common vertebral lesions. Thoracic vertebrae are commonly affected followed by lumbar and cervical vertebrae. Predisposing factors for tuberculosis include poverty, overcrowding, illiteracy, malnutrition, alcoholism, drug abuse, diabetes mellitus, immunosuppressive treatment, and HIV infection. These are also predisposing factors for spinal tuberculosis. Older age, female gender, chronic peritoneal dialysis, household crowding and previous tuberculous infection were identified as risk factors for Pott’s spine. (10G) Additionally, vitamin D deficiency has been linked to an increased risk of spinal bone loss and an increased risk of spinal fractures in individuals with Pott’s spine.

: To identify and evaluate the risk factors for Pott’s spine.

: Present study was prospective in nature conducted among 441 patients of Pott’s spine. All patients fulfilling inclusion criteria and exclusion criteria were taken up for the study. Study was carried out over a period of 3 years. Serum Vitamin D was assessed.

: Majority of the patients was in the age group of 41-50 years and most of them were male. In this study, we found that age, socioeconomic status, employment, presence of comorbidities and BMI(<18) were associated with increased risk of pott’s spine.

: This cross-sectional study investigates 441 cases of intervertebral disc degeneration leading to disc bulge/protrusion/extrusion, focusing on demographic, socioeconomic, and health-related factors. The majority of cases (31.82%) occurred in individuals aged 41-50 years, with females accounting for a larger proportion (54.55%) than males. Religious demographics revealed a prevalence of Muslims (45.57%) and Hindus (42.17%), with bilateral involvement common. A substantial portion of patients resided in slum areas (60.09%), reflecting socioeconomic disparities, with the majority (60.31%) belonging to the lower socioeconomic status. Most patients reported symptoms lasting less than 6 months (61.36%) and came from families with 5 or more members (85.48%). Addiction history (78.45%) and pre-existing co-morbidities (65.75%) were prevalent. Notably, no significant associations were found between serum Vitamin D levels and demographic factors. Among the employed, a significant proportion were unemployed (31.97%), underscoring socioeconomic challenges. These findings provide comprehensive insights into the multifaceted nature of intervertebral disc degeneration, crucial for informing targeted interventions and management strategies.