bluuebunny/crossref_metadata_2025 huggingface dataset:
Rachunkowość zrównoważona w ujęciu kognitywno-teoretycznym
Authors: Zyznarska-Dworczak Beata
Published: February 2023

Rachunkowość podlega nieustannym procesom ewolucyjnym. Od lat jej rozwój jest stymulowany przez rozwój gospodarczy, a także rozwój społeczny i środowiskowy. W ostatnich dekadach proces ewolucji rachunkowości nabrał większego tempa, na co wpłynęła w szczególności koncepcja rozwoju zrównoważonego. Szybkość zmian działań praktycznych i badań naukowych w zakresie rozwoju zrównoważonego nie pozwoliła dotychczas na jednoznaczne wskazanie roli rachunkowości w tym obszarze. Przeprowadzone w niniejszej rozprawie rozważania wypełniają lukę badawczą dotyczącą wykorzystania rachunkowości przedsiębiorstwa na potrzeby rozrachunku przedsiębiorstwa z tytułu jego ekonomicznej, społecznej i środowiskowej odpowiedzialności. Autorka analizuje przesłanki rozwoju rachunkowości na potrzeby sprawozdawczości z dokonań przedsiębiorstwa zrównoważonego oraz zarządzania nim w świetle teorii pozytywnych i normatywnych, a następnie podejmuje próbę konceptualizacji rachunkowości zrównoważonej. W konstruowaniu ram koncepcyjnych autorka przyjmuje założenie, iż rachunkowość zrównoważona może niezmiennie stanowić bazę normatywną, odwzorowującą społeczno-ekonomiczne zjawiska gospodarcze z uwzględnieniem ochrony środowiska, oddziaływania społecznego i etycznych zasad komunikowania informacji. Ramy koncepcyjne ukazują sposób integrowania rachunkowości zrównoważonej ze stosowanym przez przedsiębiorstwo systemem rachunkowości finansowej i zarządczej organizacji w celu generowania informacji finansowych i niefinansowych o stopniu realizacji zasad rozwoju zrównoważonego. Ramy koncepcyjne kreują także rolę rachunkowości zrównoważonej w kształtowaniu społecznych relacji z interesariuszami przedsiębiorstwa. Poprzez właściwe ukierunkowywanie instytucjonalizacji praw i obowiązków kluczowych interesariuszy organizacji, a także sankcjonowanie norm i wartości moralnych w komunikowaniu dokonań, wspierają faktyczną legitymizację działalności związanej z realizacją zasad rozwoju zrównoważonego.
The evaluation of breast biopsy results before and after the inception of COVID-19 pandemic: Single center retrospective study
Authors: ULU ÖZTÜRK Funda , TEZCAN Şehnaz
Published: February 2023

Aim: This study aimed to evaluate breast biopsy procedures performed in radiology unit before and after COVID-19 pandemic initiation, and compare breast cancer diagnosis.

Material and Methods: Breast biopsies performed two years before and after March 2020 were retrospectively analyzed. Patient demographics, referral reason (screening/diagnostic), biopsy type and region, tumor size, BI-RADS category and pathology were evaluated. Statistical analysis was made using chi-square test, independent samples t-test and Mann-Whitney U test.

Results: Among 903 biopsies, the mean age was 51 (range 15 to 88 years). Biopsy volume decreased in the early six months of the pandemic, but accelerated soon after, with numbers even more than the pre-pandemic era. Screening intention on patient referral decreased significantly in the pandemic period, where diagnostic purposes arised (p
A Case Study of a Successful Park and Recreation Voter Referendum
Authors: Pitas Nicholas Andrew , Kerins Andrew , Zou Sharon , Jaquet Izabelle
Published: February 2023

Although other sources exist, tax-based funding accounts for the majority of operating budgets for NRPA member agencies. To keep pace with ongoing maintenance and service needs, and to increase agency capacity to provide services into the future, many municipal and county level agencies often turn to voter referenda – a form of direct democracy, wherein citizens in a given area hold decision making authority in specific elements of the public policy process – to increase tax-based funding. These referenda take a variety of forms, including permanent increases to property, income, or sales tax, or the approval of a one-time bond resolution. Despite their prevalence and importance, the scholarly body of work addressing the referendum process as a tool for open-space and environmental conservation is relatively small, with very little scholarly work specifically addressing referenda focused on community level park and recreation services. The purpose of this manuscript is to begin to address the gaps in knowledge surrounding the referendum process, specific to the financing of community park and recreation services. We employ a qualitative case study approach to examine the historical and contemporary context of a successful park and recreation referendum, conducting in-depth key-informant interviews with stakeholders within and external to the agency.
Breeding Lines Influence on Growth, Yield and Quality Characteristics of Cutleaf Groundcherry (Physalis angulata L.)
Authors: Yamika W.S.D. , Waluyo B. , Aini N. , Sebayang H.T.
Published: February 2023

Background: Physalis angulata L. or Cutleaf groundcherry is underutilized crop that has not been widely cultivated and is often considered weeds. Cutleaf groundcherry is rich in nutritional and phytochemical contents, which is beneficial for human health. Information on the growth, yield and quality content of cutleaf groundcherry lines is essential for future development. The objective of this experiment was to determine the variation among the lines of cutleaf groundcherry in growth, yield and fruits quality. Methods: A greenhouse study was conducted in August to December, 2021. Nine lines of cutleaf groundcherry were tested in randomized block design by following the recommended agronomic practcies. Result: The results show that nine lines of cutleaf groundcherry were varied with significant differences in growth, yield and quality characteristics. The line PA-06 was superior to other lines in vegetative growth and total dry weight, yield characteristics, namely fruit weight fruit-1, fruit diameter and fruit weight plant-1. The nine lines had the same as total soluble solids and ascorbic acid, but differences in β-carotene and antioxidant.
Effect on Physic-chemical Quality of Soymilk Blended Channa based Sweetmeat by using Natural Coagulant
Authors: Honkar A.S. , Hembade A.S.
Published: February 2023

Background: Animal origin protein prices are beyond the purchasing capacity of average population. So for those who cannot afford costly protein available in market, plant origin protein source is very good choice e.g. Soybean. Many food scientists are working on to enhance the nutritive value of milk products. In this investigation an attempt has been carried out to enhance nutritive value of sweetmeat with low cost of production by using natural coagulant. Methods: In this investigation soymilk used for partial replacement of cow milk in order to reduce cost of production of Channa Murki. Passion fruit juice (PFJ) having good nutritional properties successfully used for coagulation. Result: From this investigation it has been concluded that passion fruit juice can be successfully used instead of traditional coagulants in making of coagulated dairy products with high nutritive value.
Unidad Didáctica:
Authors: Rodríguez García Dora Marcela , Díaz Aldana Ana Patricia
Published: February 2023

Unidad Didáctica: la enseñanza del control organizacional, es resultado del proyecto de investigación con SGI 2753 titulado “Didáctica de las ciencias sociales”, el cual se obtuvo por medio de un trabajo interdisciplinar que aporta a los procesos de formación de los programas Contaduría Pública y Administración de Empresas de la Universidad Pedagógica y Tecnológica de Colombia, Facultad Seccional Chiquinquirá. Se configura como un acercamiento a la enseñanza - aprendizaje del control organizacional, que aplica un estilo que va más allá de los enfoques tradicionales de educación.En esta unidad didáctica, se consideraron elementos relevantes en la formación, como los conocimientos previos y las experiencias propias de los estudiantes, saberes imprescindibles en el proceso de enseñanza – aprendizaje. Punto de partida para que el docente estructure pautas, actividades y técnicas a desarrollar en el aula, al ceder paso a la transposición didáctica, con la finalidad de potenciar el pensamiento crítico y la evolución conceptual.Finalmente, este texto, deja entrever el diseño, implementación y evaluación de una unidad didáctica de control organizacional, que surge de las ideas previas de la población objeto de estudio, estudiantes de los programas Contaduría Pública y Administración de Empresas. Así, esta investigación, convoca a los profesores a contar con el uso de nuevas estrategias pedagógicas y didácticas que alcancen el conocimiento científico y la evolución conceptual en los discentes, sin desconocer los métodos cognoscitivos y su aplicación en contextos reales, para fomentar un aprendizaje permanente en el que se considere al estudiante y al docente, como actores dinámicos dentro del proceso formativo.
Psikolojik Danışmanlarda Şefkat Yorgunluğu Ölçeğinin Geliştirilmesi
Authors: ÜMMET Durmuş , METİN Süleyman , OKUR Sinan
Published: February 2023

Bu araştırmanın amacı ruh sağlığı alanında çalışan psikolojik danışmanların şefkat yorgunluğu düzeyini ölçmek üzere bir ölçme aracı geliştirmektir. Araştırmanın çalışma grubunu toplam 725 (518 kadın ve 207 erkek) psikolojik danışman oluşturmaktadır. Araştırmada açımlayıcı faktör analizi, doğrulayıcı faktör analizi, ölçüt bağıntılı geçerliği, Cronbach alfa iç tutarlık değeri ve madde analizi hesaplanarak ölçeğin psikometrik özellikleri ortaya konmuştur. Açımlayıcı faktör analizi sonucunda toplam varyansın %53’ünü açıklayan 21 maddelik dört boyutlu bir ölçek elde edilmiştir. Ölçek faktör yükleri .504 ile .781 arasında değişmektedir. Ölçeğin dört boyutlu yapısı farklı bir örneklem grubu üzerinde doğrulayıcı faktör analizi yapılarak test edilmiştir. Yapılan analiz sonucunda model ile veri arasında uyumun kabul edilebilir düzeyde olduğu saptanmıştır (χ2= 315.43, p= .000, sd= 181, χ2/sd= 1.74, CFI= .91, TLI= .90, SRMR= .05, RMSEA= .06). Ölçeğin madde tahmin değerleri ise .39 ile .80 arasında değişmektedir. Bunun dışında, farklı bir örneklem ile yapılan ölçüt bağıntılı geçerlik çalışmasında da istatistiksel olarak anlamlı ilişkiler bulunmuştur. Güvenirlik analizleri kapsamında yapılan analizlerde ölçeğin geneli için Cronbach alfa iç tutarlık katsayısı .890 ve Guttman katsayısı .872 olarak hesaplanmıştır. Alt boyutlar için ise Cronbach alfa iç tutarlık değeri .683 ile .836 arasında değerler almıştır. Benzer şekilde alt boyutlar için Guttman katsayısı da .612 ile .837 arasında değişmektedir. Ölçeğe ilişkin madde toplam korelasyon değerleri hesaplandığında .374 ile .701 arasında değerler olduğu belirlenmiştir. Tüm bu bulgular, Psikolojik Danışmanlarda Şefkat Yorgunluğu Ölçeğinin geçerli ve güvenilir bir ölçme aracı olduğunu kanıtlar niteliktedir. Araştırmada elde edilen sonuçlar alanyazında yer alan araştırmalar dikkate alınarak tartışılmış ve yorumlanmıştır.
Cesaretin Felsefesi: Platon’a Göre Cesaret Erdeminin Önemi
Authors: SOYSAL Özgür
Published: February 2023

Bu makalenin amacı cesaret erdeminin Platon’un politika felsefesinde genel olarak kabul edildiğinden daha belirleyici ve merkezi bir role sahip olduğunu ortaya koymaktır. Bu rolün öneminin Platon’un hem hocası Sokrates’in bir filozof olarak yaşamında sergilediği ve hatta hayatına mal olan cesaretinin farklı boyutlarını bir araya getirme çabasından hem de genel olarak, felsefe ile politikanın uzlaşabileceği ideal devlet çözümünün ayrılmaz bir parçası olmasından ileri geldiği iddia edilecektir. Platon’un dönemin politik düşüncesinde kahramanlıkla birlikte düşünülen cesarete oldukça farklı bir felsefi bir anlam ve rol vermeye çalıştığı savunulacaktır. Bu yolda Platon felsefesinde cesaretin aklın (bilgeliğin) arzuları (bedeni, maddi dünyayı ve devleti) yönetebildiği ideal bir düzen inşa etme hedefi açısından neden zorunlu bir işleve sahip olduğu gösterilmeye çalışılacaktır. Bu açıdan, makalenin iddiası, cesaret erdemine dair bu bakış açısının, Platon’un, Sokrates’in kişiliğinde somutlaşan felsefi yaşamı, doğru ve adil bir yaşam olarak sitede inşa etme yönündeki çözüm arayışının farklı boyutlarını anlamaya katkıda bulunabileceğidir.
Proto-Macarlar ve Orta Çağ’da Türklerle İlişkileri
Authors: MIZRAK Egemen Çağrı
Published: February 2023

Uralik halklar zümresinin Ugor kolu menşeli Proto-Macarların tarihi, başlangıç sahası olarak kabul edebileceğimiz kadim ana-yurt coğrafyası (Urheimat) olan Ural Dağları’nın doğusundan Batı-Güney Sibirya’ya uzanan geniş coğrafyada Türk kökenli halklarla iç içe olmuştur. Günümüzde dahi bu ortaklığın (Türk-Ugor) maddi verileri ilk yurt diyebileceğimiz Sibirya’da gerek antropolojik ve genetik gerekse de sosyo-kültürel safhalarda görülmektedir. Macarların, bilinen ilk yurtlarına dair bilgiler ise bizi daha çok Ural Dağları’nın güneyi, Kama-Yayık nehirleri arası ve doğusuna, bilhassa Başkirya sahasına götürmektedir. Tarihi ve coğrafi kayıtlar bağlamında Macar-Türk bağlantısının en etkin bir şekilde varlığından bahsedebileceğimiz dönem MS V. yüzyılda vuku bulan büyük Ogur göçleriyle başlamakta ve MS IX. yüzyılın sonlarına kadar uzanmaktadır. Bu zaman diliminde Macarların, Hun-Ogur-Sabir-Hazar-Gök Türk unsurlarıyla güçlü bağlar kurdukları ve kaynaklarda genel itibariyle Türklerle ilişkilendirildikleri görülmektedir.
Reflexões de um cineasta indígena sobre o cinema indígena contemporâneo
Authors: Mongconãnn Ítalo
Published: February 2023

O presente texto é uma reflexão das inquietações de um cineasta indígena sobre os dias atuais, o qual teve como ponto de partida a conversa entre os realizadores indígenas Graciela Guarani e Alexandre Pankararu por meio de uma Live realizada pela Fundação Cultural Badesc de Florianópolis, SC. Ao longo do diálogo vários pontos foram abordados, como propor outras linguagens e gêneros de produção, ver o cinema indígena como área de emprego, pensar sobre a distribuição e o público dessas produções. Onde independente de todos os aspectos levantados, o cinema indígena é e sempre será uma forma de resistência e enfrentamento.
The jumara festival of Panamá
Authors: Izard Gabriel
Published: February 2023

Based on an ethnography of the First Jumara International In-digenous Film Festival, which took place in an Emberá com-munity in Panama, the aim of this article is to delve deeper into the connection between the processes of ethnicity derived from Indigenous cinema and the processes of ethnicity deri-ved from the meaning given to that cinema at specific even-ts. At Jumara, Indigenous cinema was the reason for affirming Emberá culture and for championing, in a markedly festive and performative way, the group’s main demands in a celebration in which the body and its ornamentation took on a special role. It is argued that the ethnographic focus on festivals organized in Indigenous communities makes it possible to fully analyze the committed and activist dimension of Indigenous cinema.
A eternidade de Wiñaypacha como imagem do pensamento andino
Authors: Caballero Indira Nahomi Viana
Published: February 2023

Recentemente estreou Wiñaypacha (título em espanhol Eternidad), o primeiro filme peruano longa-metragem integralmente falado em aimará, alcançando imenso sucesso não só nos cinemas do Peru como internacionalmente. O filme dirigido por Óscar Catacora, jovem cineasta peruano de origem aimará, é uma obra-prima tanto por suas qualidades estéticas quanto narrativas. O objetivo deste artigo é mostrar como fotografia e roteiro, também assinados pelo diretor, têm um forte caráter poético e potente enquanto recursos reveladores do pensamento andino, sendo a ideia de Eternidade central nesse sentido. Por fim, trata-se de destacar o protagonismo que os povos andinos alcançam com o sucesso de Wiñaypacha em lugares onde há muito tempo são/estão presentes, porém, vistos predominantemente como coadjuvantes.
Devoradores de deuses
Authors: Macedo Rafael Gonzaga de
Published: February 2023

Partindo de uma fotografia de uma máscara elmo iorubá presente na obra Negerplastik de Carl Einstein, o artigo procura demonstrar que, ao contrário do que possa parecer à primeira vista, nenhuma fotografia é transparente e que seus pressupostos visuais estão ancorados na experiência do olhar imperial ocidental sobre o outro. Trata-se de explorar as implicações de uma postura que considera a fotografia não meramente como uma ferramenta para a divulgação das artes ditas primitivas, mas como vetor de um devir maquínico dessas artes, devorando e produzindo imagens que expressam uma sensibilidade específica e imperial com sua historicidade e seus dilemas.
Mirando mundos possíveis
Authors: Costa Ana Carolina Estrela da , Neves André Luís Lopes , Marin Nadja Woczikosky
Published: February 2023

Este relato narra a experiência de concepção e construção da plataforma virtual “Mirando Mundos Possíveis: (Re)Existir e Curar”, que reúne uma série de produções audiovisuais realizadas por povos indígenas durante o período da pandemia. O mosaico de vídeos criado a partir desta experiência emerge como uma potente expressão de como povos indígenas, em sua multiplicidade, oferecem perspectivas igualmente múltiplas acerca deste momento dilatado de rupturas. A criação desta plataforma insere-se em meio à recente trajetória de formação da Rede CineFlecha, uma rede que articula diversos coletivos indígenas de cinema junto a seus parceiros não-indígenas.
Carnaubal
Authors: Pereira Lucas Coelho
Published: February 2023

Ganhador do Prêmio Mariza Corrêa na modalidade Ensaio Visual.
Editorial
Authors: Paccillo Giovanna , Silva Jinx Vilhas Mauricio da , Limão Gabriela , Saldanha Inácio dos Santos , Augusto Isabela Cassis , Serber Luiza , Negretti Natalia , Del Pino Ramón
Published: February 2023

Editorial da Proa: Revista de Antropologia e Arte, v. 11, nº 2, 2021.
Brasília teimosa, de Bárbara Wagner, diante das tradições e tendências contemporâneas da fotografia documentária
Authors: Almeida Cyro
Published: February 2023

A pesquisa investiga a série de fotografias Brasília Teimosa, realizada entre 2005 e 2006, pela artista brasileira Bárbara Wagner. Situada na esfera da fotografia documentária, suas imagens colocam, de antemão, questionamentos a esse legado, utilizando-se da cor e da luz artificial, da performatividade dos personagens e da apropriação de fórmulas midiáticas para elaboração de retratos. Por isso examinei os modos pelos quais Brasília Teimosa afasta-se das tradições fotodocumentárias e em que medida dialoga com proposições contemporâneas dessa abordagem.
O espetáculo do constrangimento
Authors: Figueiredo Wallace de
Published: February 2023

Este artigo analisa a performance dos lutadores de MMA no documentário The Hurt Business (O Espetáculo da Dor). O texto apresenta a construção da identidade do lutador através do conceito de individualismo pensado por Gilberto Velho, e utiliza tanto a Jornada do Herói de Joseph Campbell quanto a ideia de constrangimento de Goffman para mostrar o sentido das construções narrativas após a derrota, fomentando no lutador motivos para uma busca incessante pela vitória.
The analysis of village financial management and reporting in Simeulue district
Authors: Rasyid Ainul , Darwanis  , Yusmita Fifi
Published: February 2023

This study aims to determine the appropriateness of village funds management and reporting budgets in Simeulue Regency based on the Regulation of the Ministry of Home Affairs Number 20 of 2018 and the Regulation of Simelue Regent Number 78 of 2018 concerning village fund management. This research is a study in all villages in Simeulue District in 138 villages. Data collection from this study was interviews and observations of 138 villages as the object of this research. Respondents in this research consist of two people in each village, with a total of 276 respondents. A qualitative descriptive was employed as the analysis method. Data were collected from interviews, observations and documentation. The results showed that the stages of village fund management in Simeulue Regency were following the mandate instructed by the Permendagri and the 2018 Simeulue regent regulation. Regarding managing the village fund budget, reporting, and accountability, there were still two villages, namely Lhok Makmur and Sembilan Villages, whose budgets still needed to be in order, resulting in reporting and accountability delays. Such conditions are caused by a lack of ability of the financial coordinator since the treasurer has newly served in that position. The implications of the findings are expected to be the basis for policymakers to manage village funds in the future.
Predictors of academic performance of distance e-learners in a Nigerian University
Authors: Aboderin Olukayode Solomon , Govender Desmond Wesley
Published: February 2023

This study was designed to analyze the predictors of the academic performance of distance e-learners. The population consisted of all distance learners in the university study centers in the South-West geopolitical zone. The sample of the study was made up of 1025 respondents from the university, which were selected using a purposive sampling technique. A mixed-method approach was used for the collection of data. This study applied ordinal regression analysis in searching for the best predictors among the variables under investigation in predicting the academic performance of distance e-learners. A quantitative approach was used to determine the best predictors. In contrast, a qualitative approach was used to support the quantitative results and reveal other variables not covered in the questionnaire. Results showed that five variables best predicted academic performance, and together they explained 10% of the variance in academic performance after considering all the rules that guide ordinal regression analysis. Frequency of engagement with information and communication technology (ICT) was found to be the strongest predictor, followed by students’ ICT literacy levels, marital status, previous academic performance and entry qualification. Based on the study's findings, it was recommended that policymakers and educational stakeholders fully support the implementation of e-learning in Nigerian universities.
Exploring factors contributing to unplanned pregnancies among students at higher education institution in South Africa
Authors: Kgarose Mathibedi , Mashiane Phindile Precious , Machaka Meyahabo
Published: February 2023

Unplanned pregnancies among female undergraduate & postgraduate students at higher education institution pose severe public health issue in South Africa (SA) and are also linked to bad health and social consequences that have a detrimental influence on academic advancement and future employment opportunities. The number of unplanned pregnancies among students at higher education institutions continues to rise, despite the government introduction of contraceptives and other preventative methods. Thus, the objective of this study was aimed at explore factors that contribute to unplanned pregnancies among students in higher institution of learning The study adopted non-empirical research, in which existing literature on factors that contributes to unplanned pregnancies among students in higher education institutions. This paper is solely based on a review and analysis of published research and data. The findings of this study indicate that peer pressure, contraceptive uptake, and substance abuse contribute to unplanned pregnancies among students at higher education institution. Peer pressure and inconsistent contraceptive usage are the two interdependent factors that significantly impact unplanned pregnancies at higher education institutions. However, it seems that the lack of sexual knowledge makes these problems worse. The paper notes factors such as peer pressure, contraceptive uptake, and substance abuse that contribute to unplanned pregnancies among students at higher education institutions. The paper recommends adopting policies that emphasize sexual abstinence or the use of contraceptives inclusive of condoms and the government to introduce a long-term injectable contraceptive.
Assessment of the effect of resource allocation on digital transformation in the Zimbabwean life insurance industry
Authors: Chiguvi Douglas , Zaranyika Tafadzwa , Marozwa Manuel , Zhou Noel
Published: February 2023

The present study attempts to assess the effect of resource allocation on digital transformation in the Zimbabwean Life insurance industry. The study used a positivist research philosophy and a quantitative research approach. Data was collected using an email survey questionnaire from employees and management of four big Life insurance companies in Zimbabwe. The study findings revealed that resource allocation positively influenced digital transformation in the Zimbabwean Life insurance industry. The study recommends that managers in the Life insurance industry hire technologically proficient people to ensure digital transformation success and hire digital transformation consultants to help them with their digitalization process. Life insurance companies are urged to develop a digital transformation strategy. Future researchers are urged to look at other factors which affect digital transformation.
Forecasting volatility in oil returns using asymmetric GARCH models: evidence from Tanzania
Authors: Mbwambo Haika Andrew , Letema Laban Gaspe
Published: February 2023

Crude oil is, without a doubt, one of the most significant commodities in the modern world. The highly contagious coronavirus, the conflict between Ukraine and Russia, and not to mention the unusual turn of events worldwide have all significantly impacted crude oil prices. Since oil is required for all critical economic activities, such as production and transportation, a forecast for crude oil prices is essential. Using a range of GARCH models at such an intense time, this study attempted to close this gap by forecasting crude oil volatility. To forecast the returns of Brent crude oil prices from January 2002 to February 2022, this study uses a family of GARCH models. In the respective family of models, GJRGARCH (1,1) was the most effective in predicting the volatility of crude oil prices. The GJRGARCH model was chosen since it had a higher likelihood value and a lower information criteria value. A diagnostic check was done to evaluate the produced model further to ensure that the proposed model was good enough for forecasting crude oil volatility. The study suggests employing the GJRGARCH technique to predict future fluctuations in exceptional circumstances.
The effect of use, task technology-fit, user satisfaction on performance of the Kimia Farma Pharmacy employees in Yogyakarta business unit
Authors: Adhitya Mahatva Yodha  , Nuryakin  , Arni Suwanti
Published: February 2023

This study aims to determine the effect of the use of information technology on employee performance, which is mediated by user satisfaction and the suitability of technology tasks. Respondents in this study were employees of PT Kimia Farma Pharmacy Yogyakarta Business Unit. The sample used was 110 respondents, with a quantitative method using SEM and AMOS. From the data that has been tested and collected, the results of this study indicate that the use of information technology has a significant positive effect on employee performance and task-technology fit. User satisfaction and task-technology fit do not mediate the positive and insignificant effects of using information technology on employee performance. User satisfaction has no positive effect on performance and is insignificant. Task-technology fit has a positive effect on performance.
Forgotten “Primum Non Nocere” and Increased Mortality after Covid-19 Vaccination
Authors: Šorli Srecko , Makovec Tomaz , Krevel Zivan , Gorjup Rado
Published: February 2023

Background. The main impetus behind the worldwide Covid-19 vaccination campaign in 2021 was to reduce the mortality attributed to SARS-CoV-2 infection in the preceding year. Nevertheless, rigorous analyses of the mortality benefits conferred by this massive vaccination effort have been lacking. Methods Statistics offers us an essential methodological approach for measuring the impacts of Covid-19 vaccination on public health. The mathematical relation between vaccinated-alive groups can be repeated between vaccinated-dead groups with relatively high statistical reliability because of the large population numbers involved. This method also confers greater statistical usefulness because it eliminates the Simpson effect. Results Calculations were performed for each of the following five four-week intervals: weeks 35-38 (2021), weeks 39-42 (2021), weeks 43-46 (2031), weeks 47-50 (2021), and weeks 51(2021)-2(2022). The results obtained confirm that the mortality of the vaccinated coronavirus-infected groups was 14.5% higher on average than the mortality of non-vaccinated coronavirus-infected groups. Conclusions Vaccinated infected groups appear to have higher average mortality than their non-vaccinated infected counterparts. The findings suggest the legitimacy of extending the statistic between vaccinated living and vaccinated dead individuals for different age groups. Calculating the impact of Covid-19 vaccination on the mortality rate is a necessary step toward satisfying the first principle of medicine: “Primum non nocere”, “Do no harm”.
Novel Data Analyses Explain the Birth-Cohort Phenomenon of Peptic Ulcers
Authors: Dong Simon Xin Min
Published: February 2023

Background: The birth-cohort phenomenon of peptic ulcers has remained an unresolved mystery for 60 years since it was first reported in 1962. Currently, peptic ulcers are widely studied as an infectious disease caused by Helicobacter pylori, but this etiology cannot explain this phenomenon. A recently published etiological theory identified peptic ulcers as a psychosomatic disease triggered by psychological stress. This new theory addresses all the characteristics, observations/phenomena, controversies, and mysteries of the disease in a series of 6 articles. Methods: In this fourth article of the series, all the possible causes of peptic ulcers collected from literatures were classified into 3 categories, and the mortality rates caused by these categories were superposed to reproduce the fluctuation curves in the birth-cohort phenomenon. Results: The fluctuation curves in the birth-cohort phenomenon were successfully reproduced, with all the details of the phenomenon elucidated. Psychological stress induced by the First World War accounted for the increasing mortality rates in the early 1910s. The high mortality rates between 1910s and 1940s were maintained by a succession of crucial events that led to extensive psychological stress in the population. The end of the Second World War and continuous improvements in living conditions explained the fall in the early 1950s and afterwards. Conclusions: The birth-cohort phenomenon cannot be fully understood unless peptic ulcers are considered a psychosomatic disease triggered by psychological stress. A full explanation of the birth-cohort phenomenon exemplifies the application of a brand-new methodological concept, superposition mechanism, which can be universally applied to understand any life phenomenon and human disease.
La temperatura nasal: marcador autonómico de relajación y su relación con el apoyo social en adultos mayores
Authors: Rodríguez Medina David Alberto , Martínez-Cuervo Nadia , Vázquez-Ortega José Joel , Manjarrez-Ibarra Jesús Omar , Ríos-Quintero Yurica
Published: February 2023

Marco Teórico: La respuesta psicofisiológica de estrés induce un tono simpático de vasoconstricción en las regiones distales del cuerpo disminuyendo la temperatura nasal y de los dedos de las manos. Para el manejo de estrés son útiles las técnicas de relajación. Sin embargo, se desconoce su efecto sobre la temperatura nasal en adultos mayores, quienes presentan dificultades de termorregulación. Se propusieron tres objetivos: 1) examinar los efectos de diferentes estrategias de relajación sobre la temperatura nasal y contrastarlos con una actividad ecológica de psicoeducación sobre el apoyo social en adultos mayores como actividad no relajante; 2) identificar quienes se benefician en cada técnica de relajación, y explorar la relación entre la temperatura nasal y el apoyo social. Método: Mediante un muestreo no probabilístico, participaron 39 adultos mayores, de manera grupal, que completaron 5 sesiones semanalmente: 4 de relajación y una de psicoeducación. Se registró la temperatura nasal pre – post sesión mediante un termómetro infrarrojo. El estudio se realizó en un espacio comunitario para actividades destinadas a adultos mayores. Resultados: Los resultados revelaron que la respiración diafragmática, la imaginería guiada y el entrenamiento autógeno incrementaron la temperatura nasal (p < 0.05) con tamaños del efecto moderados o grandes, aunque no todos los participantes presentaron el mismo efecto; mientras que la psicoeducación no mostró cambios en la temperatura nasal. Además, se encontró una asociación positiva entre la temperatura nasal y el apoyo social. Conclusiones: La temperatura nasal puede distinguir a aquellos participantes logran relajarse, de aquellos que les genera más esfuerzo.
A systematic review of economic evaluations of supervised injection and consumption facilities for people who use drugs: A study protocol
Authors: Jozaghi Ehsan
Published: February 2023

Background:
There are now more than 100 supervised injection facilities (SIFs) operating in numerous jurisdictions, including Australia, Canada and Western Europe. However, despite the increasing prevalence of people who use or abuse illegal drugs, including those who inject drugs, there are currently no operating SIFs in Africa, Asia, Central and South America and Eastern Europe. With the exception of Canada in North America, no sanctioned facility currently operates in the United Mexican States or the United States of America. This is the first study to systematically synthetizes the overall benefits and cost-effective ratios associated with operating SIFs, hypothetical SIFs, or drug consumption sites in different jurisdictions.
Methods and Analysis:
In this systematic review, through relying on five electronic scientific data bases, the peer-reviewed studies, reports, and theses that have evaluated the cost and benefits of supervised injection or consumption facilities will be identified. Based on the inclusion criteria, all initial articles will be identified and screened via title and abstract. All the articles collected through the initial search will be additionally screened to extract further information and data related to costs, benefits, programs, or services. The final data analysis will include the average cumulative benefits, costs, and ratios associated with operating SIFs.
Discussion:
This review has the potential to provide evidence-based knowledge related to the cost-savings of public health interventions implemented via harm reduction approaches for marginalized populations. However, it is important to emphasize that SIFs are an integral part of health care system for the marginalized populations and their establishments should not be based on health care costs, rather based on human rights.
Systematic review registration: PROPSERO CRD42018100324
Bayesian compositional regression with microbiome features via variational inference
Authors: SCOTT DARREN A. V. , BENAVENTE ERNEST DIEZ , LIBISELLER-EGGER JULIAN , FEDOROV DMITRY , PHELAN JODY , ILINA ELENA , TIKHONOVA POLINA , KUDRYAVTSEV ALEXANDER , GALEEVA JULIA , CLARK TAANE , LEWIN ALEX
Published: February 2023

The microbiome plays a key role in the health of the human body. Interest often lies in finding features of the microbiome, alongside other covariates, which are associated with a phenotype of interest. One important property of microbiome data, which is often overlooked, is its compositionality as it can only provide information about the relative abundance of its constituting components. Typically, these proportions vary by several orders of magnitude in datasets of high dimensions. To address these challenges we develop a Bayesian hierarchical linear log-contrast model which is estimated by mean field Monte-Carlo coordinate ascent variational inference (CAVI-MC) and easily scales to high dimensional data. We use novel priors which account for the large differences in scale and 1 constrained parameter space associated with the compositional covariates. A reversible jump Monte Carlo Markov chain guided by the data through univariate approximations of the variational posterior probability of inclusion, with proposal parameters informed by approximating variational densities via auxiliary parameters, is used to estimate intractable marginal expectations. We demonstrate that our proposed Bayesian method performs favourably against existing frequentist state of the art compositional data analysis methods. We then apply the CAVI-MC to the analysis of real data exploring the relationship of the gut microbiome to body mass index.
MiR-125 family improves the radiosensitivity of head and neck squamous cell carcinoma
Authors: Wang Qi-Wei , Liu Jiang-Tao , Tan Li-Jun , Zhao Jian-Nan , Zhou Xiao-Jie , Yu Tian-Jiao , Sun Ya-Nan
Published: February 2023

Backgroud: MiRNAs can affect the radiosensitization of head and neck squamous cell carcinoma (HNSCC). We aimed to analyze the function of miR-125 family members in HNSCC using The Cancer Genome Atlas (TCGA) and determine their effect on radiation in laryngeal squamous cell cancer (LSCC).
Methods: First, we systematically analyzed the role of the miR-125 family in HNSCC using the TCGA database and found that miR-125a-5p is associated with radiotherapy. We then performed comprehensive enrichment analysis of miR-125a-5p and predicted target genes. Then, we performed transfection, cell proliferation assays, reverse transcription polymerase chain reaction, apoptosis assays, micronucleus tests, and western blotting on hep-2 cells selected with puromycin.
Results: MiR-125 family members exhibited significantly different expression in HNSCC. They were significantly associated with tumor–node–metastasis staging, clinical stages, and histological grades. Radiation therapy had a statistically effect on miR-125 family members, except miR-125a-3p. Moreover, miR-125a-5p was related to overall survival in LSCC. Thus, we predicted 110 target genes and seven hub genes of miR-125a-5p. The proliferation rate of cells transfected with lentivirus vector expressing miR-125a-5p was significantly reduced compared to the other groups. The radiation effect was enhanced in cells transfected with miR-125a-5p. The ratio of apoptotic cells transfected and exposed to X-rays (10 Gy) was distinctly higher than that of the Ad-control group. Western blotting analysis revealed that miR-125a-5p upregulated the apoptotic regulators P53 and rH2AX. Thus, miR-125a-5p may increase radiosensitivity in LSCC via upregulation of pro-apoptotic genes.
Conclusions: MiR-125 family members could be prognostic biomarkers of HNSCC and improve HNSCC sensitivity to radiotherapy by activating P53. Upregulating miR-125a-5p via lentivirus vectors may be a novel strategy to strengthen the effect of radiotherapy on LSCC.
Dynamic Patterns of Gene Expression and Regulatory Variation in the Maize Seed Coat
Authors: Li Juan , Wang Liangfa , Wan Jiong , Dang Kuntai , Lin Yuan , Meng Shujun , Qiu Xiaoqian , Wang Qiyue , Zhao Jiawen , Mu Liqin , Luo Hongbing , Ding Dong , Chen Zehui , Tang Jihua
Published: February 2023

Background
Seed size is an important factor contributing to maize yield, but its molecular mechanism remains unclear. The seed coat, which serves as one of the three components of the maize grain, determines seed size to a certain extent. The seed coat also shares the maternal genotype and is an ideal material for studying heterosis.
Results
In this study, the self-pollinated seeds of the maize hybrid Yudan888 and its parental lines were continuously collected from 0 day after pollination (DAP) to 15 DAP for phenotyping, cytological observation and RNA-seq. The phenotypic data showed that 3 DAP and 8 DAP are the best time points to study maize seed coat heterosis. Cytological observations indicated that maize seed coat heterosis might be the result of the coordination between cell number and cell size. Furthermore, the RNA-seq results showed that the nonadditive genes changed significantly between 3 DAP and 8 DAP. However, the number of genes expressed additively was not significantly different. Our findings suggest that seed coat heterosis in hybrid is the result of nonadditive expression caused by dynamic changes in genes at different time points during seed expansion and seed coat development. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment indicated that genes related to DNA replication, cell cycle regulation, circadian rhythms and metabolite accumulation contributed significantly to hybrid seed coat heterosis.
Conclusion
Maize seed coat phenotyping allowed us to infer that 3 DAP and 8 DAP are important time points in the study of seed coat heterosis. Our findings provide evidence for genes involved in DNA replication, cell cycle regulation, circadian rhythms and metabolite accumulation in hybrid with high or low parental expression as major contributors to hybrid seed coat heterosis.
Sliding mode controller with fuzzy supervisor for MPPT of Photovoltaic Pumping system
Authors: Hamdi Taleb , Elleuch Khaled , ABID Hafedh , Toumi Ahmed
Published: February 2023

This paper focuses on a photovoltaic system for pumping water since the use of photovoltaic energy has grown quickly due to its direct obtainability without pollution or noise. This paper proposes a new MPPT controller based on Takagi-Sugeno type fuzzy supervisors and a sliding mode controller. The first generate the maximum power point current under varying climatic condition whereas, the second allows tracking the reference signal produced by the fuzzy supervisor. The system includes a photovoltaic (PV) generator followed by a DC-DC Converter, DC bus, an AC/DC inverter which is connected to the induction motor. This later is coupled to a centrifuge pump. The induction motor is driven based on field oriented control strategy. The Takagi-Sugeno (T-S) type fuzzy supervisors predicts, depending on the variations of climatic variables such as irradiation and temperature, the optimum operating point for the photovoltaic source. The simulation results show the effectiveness of the proposed approach in transient and stationary regimes for different values ​​of climatic variables.
Association of the Pretreatment Lung Immune Prognostic Index with Immune Checkpoint Inhibitor Outcomes in Patients with Advanced Hepatocellular carcinoma
Authors: Sun Tao , Guo Yusheng , Sun Bo , Chen Lei , Ren Yanqiao , Zhu Licheng , Zhang Lijie , Liu Yiming , Zheng Chuansheng
Published: February 2023

Objective
To evaluate whether the pretreatment Lung Immune Prognostic Index (LIPI) is associated with outcomes in advanced hepatocellular carcinoma (HCC) patients under ICI.
Methods
A two-center retrospective study of patients with HCC treated with immune checkpoint inhibitors (ICIs) between January 2018 and January 2021 was performed. The patients were stratified into three groups (good LIPI, intermediate LIPI, and poor LIPI) according to pretreatment LIPI based on dNLR (neutrophil count/ [white blood cell count - neutrophil count]) greater than 3 and LDH greater than LDH normal value. The primary endpoints were overall survival (OS) and progression-free survival (PFS). The second endpoints were disease control rate (DCR) and objective response rate (ORR).
Results
In the pooled cohort (n=224), 80 (35.7%) had a good LIPI (zero factor), 91 (40.6%) had intermediate LIPI (one factor), and 53 (23.7%) had poor LIPI (two factors). The median follow-up was 25.1 months. Median OS was 16.8 months, 12.5 months, and 9.5 months for the good, intermediate, and poor LIPI groups, respectively (P < 0.0001). Median PFS was 11.8 months, 7.8 months, and 4.0 months for the good, intermediate, and poor LIPI groups, respectively (P<0.0001) The intermediate LIPI and poor LIPI were independently associated with shorter OS, PFS，and lower ORR, DCR (P＜0.05).
Conclusion
Pretreatment LIPI was correlated with worse outcomes for ICIs suggesting that LIPI could be promising biomarker for advanced HCC patients under ICIs.
Factors affecting the total occlusion time in eyes with hyperopic anisometropic amblyopia
Authors: Utamura Keisuke , Wakayama Akemi , Matsumoto Fumiko , Shiraishi Yukari , Narita Ikumi , Tanabe Fumi , Kusaka Shunji
Published: February 2023

Purpose To investigate the factors that affected the total occlusion time (TOT) in eyes with hyperopic anisometropic amblyopia.
Methods Subjects were 58 patients (26 boys and 32 girls; age range, 3.6-9.2, average, 5.8 ± 1.3 years) with hyperopic anisometropic amblyopia. All the subjects had initially visited and completed occlusion therapy with improved visual acuity (VA) of 1.0 (0.0 logMAR equivalent) or better in the amblyopic eye at Kindai University Hospital between January 2007 and March 2017. Using the subjects’ medical records, five factors for the TOT were evaluated retrospectively: the age at treatment, the initial VA of the amblyopic eye, refraction of the amblyopic eye, anisometropic disparity, and the presence of microstrabismus.
Results The initial VA of the amblyopic eye ranged from 0.1 to 0.9 (median, 0.4). The TOT ranged from 140 to 1795 (median, 598) hours with an average daily occlusion time of 7 hours. The initial VA of the amblyopic eye and presence of microstrabismus were the influential factors for the TOT (p< 0.01). To achieve VA of 1.0 or better, patients with initial VA of ≤ 0.3 in the amblyopic eye required a longer TOT. Moreover, patients with concomitant microstrabismus required a 1.7-fold longer TOT compared to those without microstrabismus.
Conclusion Patient’s initial VA and the presence of microstrabismus are the significant factors that affect the TOT.
Labor Supply, Hourly Imbalances and Household consumption in Cameroon
Authors: Evou Jean-Pierre , Ntamack Simon Alain Song
Published: February 2023

This paper studies two things: first, the impact of observed
labor supply constraints on the welfare of household members and,
second, break down the different work times dysfunctions by
comparing observed hours to the hours actually desired by
individuals. Using ECAM IV data from 2014 and a discrete choice
collective labour supply model, it arrives at the following
results: (i) the unemployment and underemployment
constraint negatively impacts household consumption and thus their
material well-being; (ii) on the 25.53% of unemployed
women, nearly 25% of them are forced into unemployment or
inactivity. On the contrary, on the 2.54% of unemployed men, none
of them wishes to remain inactive or unemployed; (iii)
nearly one woman over four (26%) and one man over five (20%) are
forced into underemployment.

JEL code : I1 ; D6 ; J2 ; C25
Targeting MYH9 represses USP14-mediated NAP1L1 deubiquitination and enhances temozolomide response in Glioma
Authors: Chen Zigui , Yan Xin , Miao Changfeng , Liu Longyang , Liu Su , Xia Ying , Fang Weiyi , Zheng Dandan , Luo Qisheng
Published: February 2023

Myosin heavy chain 9 (MYH9) has been significantly involved in a number of diseases. Nevertheless, the function of MYH9 in glioma is unclear. The article aims to investigate the effect of MYH9 and to determine if MYH9 is also implicated in temozolomide chemoresistance of glioma. Here, we first found that MYH9 increased cell proliferation and temozolomide resistance in glioma. Mechanistic studies showed that MYH9 bound to NAP1L1, a potential tumor promoter has been reported to promote the tumor proliferation, and further inhibited ubiquitination and degradation of NAP1L1 by recruiting USP14. The up-regulated NAP1L1 increased the binding with c-Myc and further activated c-Myc, which induce the expression of CCND1/CDK4, thereby promoting temozolomide resistance and cell proliferation in glioma. In addition, we found that up-regulated MYH9 level was strongly related to patient survival and should be demonstrated as a negative factor in patients with glioma. Taken together, our results offer a new perspective on the role of MYH9 in glioma progression by regulating NAP1L1 deubiquitination, targeting MYH9 will have the possible clinical application in glioma treatment going forward.