bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of “Folk” Costume in the Sustainable Development of Ethnic Communities from Tulcea County, Romania. Case Study: Ukrainians and Russian Lipovans
Authors: Chiselev Alexandru
Published: January 2023

The article addresses the influence of traditional costumes on the identity development of two Slavic ethnic groups from Dobruja: the Ukrainians and the Russians Lipovans (Old Believers or Starovery). Adhering to certain traditional patterns, or on the contrary, adopting historical and modern symbols from Ukraine and Russia, these groups try to differentiate themselves, although at one time there was a great degree of isomorphism between their costumes. The investigation attempts to reconstruct old costume models, worn in Dobruja, elements with identity marker value, and also discusses the evolution of clothes over time, in relation to the cultural influences and the specific socio-economic environment.
Can Constancy Mechanisms Draw the Limits of Intentionality?
Authors: de Souza Filho Sérgio Farias
Published: January 2023

What are the minimal conditions for intentionality that a sensory state should satisfy for it to constitute a representational state? That is, what are the limits of intentionality? This is the problem of demarcation. The goal of this paper is to assess a specific demarcation proposal for the minimal conditions of intentionality—the constancy mechanism proposal. Accordingly, it is a minimal condition for the intentionality of a given state that the sensory system should employ a constancy mechanism in the production of this state. First of all, I introduce the problem of demarcation and show its relevance for the debate on the viability of naturalist theories of mental representation. After that, I present the explanatory role requirement for the positing of representational states by intentional explanations of behaviour and show how it constitutes a criterion for the assessment of demarcation proposals for the limits of intentionality. Finally, I assess the constancy mechanism proposal and show that its viability is seriously jeopardised by the minimal distance problem.
Roadside hawk (Rupornis magnirostris) hit by an oncoming vehicle while capturing a striped snake (Lygophis anomalus)
Authors: Lyons Sebastián , Di Pietro Diego O.
Published: January 2023

One of the most apparent origins of biodiversity loss caused by humans is infrastructural development of roads. Yet they offer certain benefits for some animals, such as hunting opportunities with lower energy costs and consumption of carrion earlier hit by vehicles. Raptors find roads a particularly favorable environment, perching on poles or overhead cables and waiting to attack their prey as it crosses a road. This paper describes the first ever recorded predation by a roadside hawk (Rupornis magnirostris) of a striped snake (Lygophis anomalus) supportable by material evidence, when both the raptor and the snake were hit by a vehicle immediately after the snake was caught. The study contributes to knowledge about the roadside hawk’s diet and illuminates the problem these human infrastructures pose for animals. Future research on roads birds of prey use as hunting sites could contribute toward improvements in conservation programs for birds of prey species.
The second egg in the lesser spotted eagle (Clanga pomarina) clutch as a nesting insurance
Authors: Kicko Ján
Published: January 2023

Over an interval of 16 days, two eggs were laid by the same lesser spotted eagle female in her nest in the west-central Slovakia in 2021. The first egg failed to hatch, and the female ate it on the 45th day after she had laid it. Thereafter, the chick hatched from the second egg and later successfully fledged. The case contributes toward explaining why the species lays a second egg, even though the younger hatched chick is almost always prone to siblicide. In this case, the second egg acts as a reserve or an insurance if the first egg should not hatch, enabling the parents to breed successfully.
STATUS BEKERJA, STRUKTUR KELUARGA DAN KERAWANAN PANGAN RUMAH TANGGA DENGAN ANAK
Authors: Yunita Hepi
Published: January 2023

AbstractHousehold food insecurity is an important issue because of its negative impact on children’s health and nutrition. This study aimed to analyze the effect of working status and family structure on food insecurity in households with children. The data used comes from the 2018 National Socio-Economic Survey. The analysis was carried out separately for poor and non-poor households using binary logistic regression. The results showed that households with heads in part-time work and those with unemployed heads were more likely to be food insecure than households with heads in full-time work in both households, whereas households with heads not in labor force were significantly more likely to be food insecure only in the poor households. In the poor households, single-male headed households were more likely to be food insecure than single-female headed households while in the non-poor households, the opposite occurred. Strengthening social safety nets, expanding employment opportunities and providing education about food insecurity needs to be done in households with children.
PENGARUH KAPASITAS SUMBER DAYA MANUSIA, PEMANFAATAN TEKNOLOGI INFORMASI, DAN PERAN AUDITOR INTERNAL TERHADAP KUALITAS PELAPORAN KEUANGAN PEMERINTAH DAERAH (STUDI PADA SKPK BANDA ACEH)
Authors: Zumaira Tasya , Rahmawaty Rahmawaty
Published: January 2023

This study aims to examine the effect of Human Resource Capacity, Utilization of Information Technology, and the Role of Internal Auditors on the Quality of Local Government Financial Reporting. The population used in this study were 44 Local Government Working Units (SKPK) located in Banda Aceh. Respondents in this study were employees who performed accounting or financial administration functions consisting of the Head of the Finance Subdivision, Revenue Treasurer, Expenditure Treasurer, and Staff of the Finance Section of each SKPK. The data collection method in this study used a questionnaire technique. The validity test used the Pearson Correlation test, while the reliability test used Cronbach's Alpha. The data analysis technique used is simple regression analysis with the help of the latest version of IBM SPSS software. The results of this study indicate that (1) Human Resource Capacity, Utilization of Information Technology, and the Role of Internal Auditors simultaneously affect the Quality of Local Government Financial Reporting, (2) Human Resource Capacity does not affect the Quality of Local Government Financial Reporting, (3) Utilization of Information Technology has a positive effect on the Quality of Local Government Financial Reporting, (4) the role of Internal Auditors does not affect the Quality of Local Government Financial Reporting.
PENGARUH INDEKS MAQASID SYARIAH DAN MODAL INTELEKTUAL TERHADAP KINERJA KEUANGAN PADA PERBANKAN SYARIAH DI INDONESIA
Authors: Ulfa Nur Eliza , Suazhari Suazhari
Published: January 2023

This research aims to evaluate the effect of the Maqasid Sharia Index (MSI) and intellectual capital (IC) on the financial performance of Islamic banking projected by ROA in BUS Indonesia within the 2016-2020 period. This research takes the sample by using purposive sampling that contains some characteristic and can represent the population as well used in this research. This research contains 12 BUS observations which were multiplied by a five-year period so that the final number of samples observed was 60. The data collected by literature study and documentation method which is carried out by collecting relevant data from various sources and tracing the related BUS annual reports according to the year period used. This research used multiple linear regression analysis and processes by SPSS 22. The results show that MSI and Intellectual capital simultaneously affects the ROA while partially MSI has a negative affect toward ROA but Intellectual Capital has no influence on the financial performance projected by ROA of BUS in Indonesia.
KOMPETENSI APARATUR DESA, SISTEM PENGENDALIAN INTERNAL DAN PEMANFAATAN TEKNOLOGI INFORMASI TERHADAP AKUNTABILITAS PENGELOLAAN DANA DESA
Authors: Fernanda Anggy Putri Aulia , Fadhlia Wida
Published: January 2023

This study aims to determine the effect of the village apparatus competence, internal control systems, and the use of information technology on the accountability of village fund management in the Village Government in Aceh Besar District. Data was collected by distributing 86 research questionnaires to respondents, namely the Village Treasurer or Finance Officer, the questionnaires which as many 86 questionnaires were completely answered. Determination of the sample using simple random sampling technique and analyzing the data using multiple linear regression model with SPSS version 28 program. The results of this study based on the responses received from 86 respondents indicate that (1) the competence of village officials affects the accountability of village fund management, (2) the internal control system affects the accountability of village fund management, (3) the use of information technology does not affect the accountability of village fund management, (4) the competence of the village apparatus, the internal control system and the use of information technology simultaneously affect the accountability of village fund management.
DETERMINING FACTORS FOR THE SELECTION OF SHARIA BANK
Authors: Setiyaningsih Rozi Fery , Pramuka Bambang Agus
Published: January 2023

This study examines the determinants of the community selection of Islamic banks. Specifically, this study aims to determine how the influence of Islamic financial literacy and service quality on the selection of Islamic banking is mediated by trust. Islamic banking is increasingly needed as a transaction medium along with an increasing number of Indonesian halal industries. Islamic banking is rapidly growing, but it has a low market share, reaching only 6.59% of Indonesia's population in July 2021. This study uses the SmartPLS 3 tool with the Partial Least Squares (PLS) analysis method. Respondents in this study were 163 respondents, namely customers of Islamic banks from the Pekalongan ex-residency. The results show that Islamic financial literacy does not affect the selection of Islamic banks, which is interesting because it turns out that Islamic financial literacy will affect the selection of Islamic banks if mediated by trust. Service quality has a significant positive effect on the selection of Islamic banks, and service quality affects the selection of Islamic banks mediated by trust. Trust affects the selection of Islamic banks. This research implies that customers need to improve Islamic financial literacy in forming trust in Islamic bank products and services. In addition, the need to improve the quality of service. Building customer trust requires a high sense of awareness and intention.
Analisa Penggunaan Video Game sebagai Media Dakwah
Authors: Prayogi Arditya
Published: January 2023

The development of da'wah today is very rapid. This rapid development is also supported through various media, including popular culture media (Pop Culture). Of the many popular cultures, video games are rarely used in da'wah media because they are often considered as trivial things, not of important value, and also considered as wasteful/consumptive activities. In fact, video games are suspected to be able to shape changes in the mindset and behavior of the players. This study uses a qualitative approach through analysis of literature obtained from books, journals and other relevant sources. This study aims to examine conceptually and practically the use of video games as a medium of da'wah that can open up opportunities to disseminate messages of da'wah massively and significantly. The results show that the phenomenon of using video games as a popular propaganda medium can theoretically be examined in three perspectives, namely video games as a way of delivering/intervention to change behavior through the learning process, video games as a simulation and a model that presents a meaningful experience, and video games as part of an environment that is able to provide various (direct) activities that are useful and meaningful from the learning aspect. Practically, the use of video games as a medium of Islamic da'wah can be realized in three ways, namely building the entire process of developing a video game platform by involving Muslim components in it. Then by inserting Islamic elements, and involving other platforms outside the video game system.
Komunikasi Organisasi Dakwah Dalam Penguatan Rohani Santri Karya Laz Daarut Tauhiid (DT) Peduli
Authors: Saadah Neng Ayu
Published: January 2023

Amil zakat merupakan kunci dalam pengelolaan zakat yang efektif di sebuah lembaga amil zakat. Sehingga dapat mengoptimalkan pengelolaan zakat secara merata sebagaimana visi-misi lembaga Daarut Tauhiid (DT) Peduli miliki. Sehingga amil zakat yang profesional akan turut berkontribusi aktif dalam memajukan dan meningkatkan kesejahteraan masyarakat. Tidaklah mudah dan diperlukan komunikasi organisasi yang baik dan cara yang efetktif dalam memberikan penguatan rohani kepada pegawainya atau seorang amil zakat agar menjadi sosok yang amanah, profesional dan jujur yang dapat berhasil mencapai tujuan bersama sebuah lembaga amil zakat. Penelitian ini menggunakan metode penelitian kualitatif yakni metode etnografi. Metode ini memiliki asumsi teoritik berisi aktivitas komunikasi pada kumpulan orang. Komunikasi organisasi yang baik akan menghasilkan sebuah organisasi atau lembaga yang sempurna. Tentu harus memiliki stratetgi-strategi tertentu. Dapat peneliti temukan jawaban dalam komunikasi organisasi dakwah dalam penguatan rohani santri karya yaitu adanya kajian rutin setiap kamis dan jumat, uprading oleh para pakar amil zakat, memahami budaya lembaga dan melakukan diklatsar seluruh santri karya. Kata Kunci: Amil Zakat, Komunikasi Organisasi Dakwah
Evaluasi Tingkat Pengetahuan Penggunaan dan Penyimpanan Antibiotika pada Masyarakat di Kecamatan Ampenan Periode April–Juli 2021
Authors: Puspitasari Candra Eka , Meivira Audra , Dewi Ni Made Amelia Ratnata
Published: January 2023

Penggunaan dan penyimpanan antibiotik yang rasional dapat meningkatkan efektivitas terapi. Pengetahuan yang rendah mengenai obat dapat mengakibatkan tidak tercapainya tujuan terapi, termasuk pengetahuan penggunaan antibiotik sehingga perlu adanya studi yang bertujuan untuk mengetahui tingkat pengetahuan penggunaan dan penyimpanan antibiotika serta mengetahui hubungan faktor demografik partisipan terhadap tingkat pengetahuan penggunaan dan penyimpanan antibiotik. Penelitian dilakukan di Kecamatan Ampenan, Kota Mataram, Nusa Tenggara Barat adalah cross sectional melalui survei dengan media kuesioner. Pengambilan sampel dilakukan menggunakan metode cluster sampling yang melibatkan 120 KK (Kepala Keluarga). Instrumen penelitian yang digunakan berupa kuesioner tertutup dengan total 29 pertanyaan. Data yang diperoleh kemudian dianalisis secara deskriptif dan selanjutnya diuji korelasi menggunakan Uji Chi Square untuk mengetahui hubungan antar variabel penelitian. Hasil penelitian diperoleh bahwa tingkat pengetahuan penggunaan dan penyimpanan antibiotika di Kecamatan Ampenan termasuk kategori baik yaitu secara berurutan dengan total presentase yang menjawab sebesar 53% dan 83%. Terdapat hubungan yang bermakna antara tingkat pengetahuan penggunaan dengan jenis kelamin (0.038), pekerjaan (0.014) dan usia (0.012). Terdapat pula hubungan bermakna antara tingkat pengetahuan penyimpanan dengan jenis kelamin (0.002) dan pekerjaan (0.008).
Asuhan Kefarmasian Beberapa Kasus Penggunaan Obat Penyakit Kulit
Authors: Indriyanti Niken , Antadini Antadini , Emor Jorgi Imanuel , Maulana Pabely Nahwan
Published: January 2023

Penggunaan obat untuk gangguan pada kulit berupa alergi maupun infeksi memerlukan instruksi khusus. Laporan kasus ini bertujuan untuk membahas asuhan kefarmasian yang tepat untuk beberapa kasus penggunaan obat penyakit kulit. Metode yang digunakan adalah metode prospektif pada pelayanan kefarmasian di beberapa apotek di Samarinda. Perijinan pengambilan data berdasarkan perjanjian kerjasama antara Fakultas Farmasi Unmul dengan apotek. Didapatkan hasil bahwa asuhan kefarmasian pada kondisi alergi dan infeksi kulit perlu disampaikan oleh apoteker dan dipahami oleh pasien, sehingga terapi bisa maksimal. Kesembuhan keluhan pasien menuntut kepatuhan penggunaan obat. Beberapa kendala pengaplikasian sediaan untuk kulit perlu diantisipasi supaya tepat dosis. Batas waktu penggunaan obat menjadi bagian asuhan kefarmasian yang penting. Dengan demikian, asuhan kefarmasian yang tepat dapat memaksimalkan terapi kulit.
Analytical Method Validation of Sulfamethoxazole in Human Plasma and Urine by HPLC-PDA
Authors: Notario Dion , Suwita Aprillia , Kelviyana Kelviyana
Published: January 2023

An analytical method for analyzing SMZ in human plasma and urine using high-performance liquid chromatography (HPLC) was developed. The separation was carried out on a Shim-pack GIST® C18 column (150 × 4.6 mm, 5 ?m) with a temperature setting of 30°C. The mobile phase consisted of glacial acetic acid pH 2.5: methanol: acetonitrile (70:25:5, v/v/v) at a rate of 0.8 mL/min. Detection was done using a PDA detector in the range of ?190-800 nm, and quantification was carried out at ?265 nm. Plasma sample preparation used the protein precipitation method with acetonitrile as the precipitating solvent (1:3, v/v), while urine preparation used the liquid-liquid extraction method with 0.03 M H2SO4 and ethyl acetate. The developed method was proven selective, linear (r = 0.998) for plasma and (r = 0.996) for urine, accurate (%error ?11.76% for LLOQ and ?14.08% for concentrations above), precision (%RSD ?4.52% for LLOQ and ?4.48% for the concentrations above), sensitive with 0.7 ?g/mL (plasma) and 0.17 ?g/mL (urine). Stability tests were carried out to determine the shelf life of the samples under several conditions. The developed method is valid and suitable for pharmacokinetic studies of SMZ in human plasma and urine.
Analisis Kepuasan Konsumen Terhadap Kualitas Pelayanan Swamedikasi di Apotek Kabupaten Nunukan
Authors: Setiawati Anggi , Hanifa Deasy Nur Chairin
Published: January 2023

Banyaknya Apotek sebagai salah satu sarana pelayanan kesehatan di sekitar kita memberikan kemudahan untuk memilih Apotek mana yang memberikan pelayanan yang berkualitas, tersedianya pelayanan yang berkualitas akan mendatangkan kepuasan bagi konsumen, kepuasan konsumen didapat jika pengalamannya terhadap suatu pelayanan sebanding atau melebihi harapan. Salah satu pelayanan kesehatan yang banyak terjadi di Apotek adalah swamedikasi. Penelitian ini bertujuan untuk mengetahui gambaran tingkat kepuasan konsumen terhadap kualitas pelayanan swamedikasi di Apotek Kabupaten Nunukan. Penelitian ini dilakukan dengan jenis penelitian deskriptif dan metode purposive sampling. Data dikumpulkan melalui pengisian kuesioner, sampel diperoleh dengan melibatkan 100 responden yang melakukan swamedikasi di Apotek yang ada di Kabupaten Nunukan pada bulan Agustus 2022. Data yang diperoleh diolah dengan menggunakan program Microsoft Excel kemudian dianalisis dengan membandingkan kenyataan dirasakan dan layanan yang diharapkan konsumen dalam diagram kartesius yang terdiri atas 4 bagian yaitu kuadran 1 prioritas utama, kuadran 2 pertahankan prestasi, kuadran 3 prioritas rendah dan kuadran 4 berlebihan. Berdasarkan hasil penelitian keseluruhan kepuasan konsumen terhadap pelayanan swamedikasi di Apotek Kabupaten Nunukan adalah rata rata menjawab puas dengan rata-rata nilai kenyataan dirasakan (4.43) dan rata-rata nilai layanan yang diharapkan (4.39) sehingga kesimpulannya yaitu nilai kenyataan sebanding dengan apa yang diharapakan konsumen.
Antithrombotic and Antioxidant Activities of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Ethanol Extract and Its Nanoemulsion Preparation in Swiss Webster Mice
Authors: Iwo Maria Immaculata , Adlia Amirah , Septila Silviyanita Isna , Pratama Yennie Agnes , Purkon Dicki Bakhtiar
Published: January 2023

Platelet aggregation has the potential to form thrombi and result in cardiovascular system diseases such as myocardial infarction and ischemic stroke - one of the leading causes of death globally. Traditionally, people use binahong leaves as blood thinners. Therefore, this study aims to obtain scientific data on the efficacy of binahong leaf  as antithrombotic. The efficacy test was carried out on male Swiss-Webster mice. The results showed that the ethanol extract of binahong leaves at doses of 50 (BLEE50) and 100 mg/kg bw (BLEE100) could increase bleeding time on H7 (7.61±1.79% and 3.72±1.76% vs 1.08±0.90%) and H14 (13.81±4.42% and 5.06±2.30% vs 1.66±1.09%) and coagulation time at H7 (5.01±1.36% and 4.18±1.67% vs 1.38±1.08%) and at H14 (7.92±1.97% and 7.19±1.96% vs 1.70±1.10%) significantly (p<0.05). The two doses of BLEE were formulated in the form of nanoemulsions with the Self Nano Emulsifying Drug Delivery System (NBLEE50 and NBLEE100) were also able to prolong bleeding time and coagulation time significantly (p<0.01) but only NBLEE50 prolonged bleeding time (p<0.05) significantly against BLEE50. In the test of the anti-platelet aggregation effect with ADP as an inducer, both doses of BLEE and the nanoemulsion preparation (NBLEE) could significantly (p<0.01)  inhibit platelet aggregation with a percentage of inhibition >70% which was not different from the standard (acetylsalicylic acid). In the antioxidant effect test using the DPPH method, BLEE has an IC50 = 66.08?g/mL which is classified as a strong antioxidant. Both doses of BLEE and its NBLEE could significantly (p<0.01) inhibit lipid peroxidation in plasma and liver and NO radicals formation. BLEE50 can significantly (p<0.05) reduce mean platelet volume (6.05±0.24fL vs 6.55±0.34fL) and platelet distribution width (8.52±0.36% vs 9.25±0.42%). Based on those results, BLEE has the potential to be used as an antiplatelet aggregation and antioxidant.
Alternativas sustentáveis para esgotamento sanitário de residências e assentamentos rurais
Authors: Neves Batista Salvador Nemésio , Frigo Fernando
Published: January 2023

Os esgotos sanitários gerados na zona rural podem causar a poluição do solo e das águas, colocando em risco a saúde das comunidades locais.  Este trabalho tem por objetivo apresentar e discutir soluções práticas e simples para o esgotamento sanitário de residências e assentamentos rurais. As soluções propostas são sanitária e ambientalmente adequadas, seguindo técnicas e normas apropriadas, e são compatíveis com a realidade socioeconômica dessas comunidades. Podem ser executadas utilizando mão-de-obra local, em regime de autoconstrução, com materiais acessíveis e de baixo custo, além de demandar operação e manutenção simples, com baixa ou nenhuma utilização de energia elétrica. Tais soluções, portanto, podem ser consideradas como sustentáveis e envolvem a coleta dos esgotos sanitários através de sistemas alternativos - coletores simplificados e ramais condominiais, e o seu tratamento, empregando técnicas não sofisticadas e econômicas - fossas sépticas, filtros anaeróbios, poços absorventes, valas de infiltração, lagoas de estabilização e terras úmidas (wetlands). São discutidas também o manejo e a disposição dos resíduos sólidos (lodos) provenientes do tratamento dos esgotos, que podem ser usados como fonte de matéria orgânica (esterco) para o solo em determinadas culturas.
Populações tradicionais e a construção de usinas hidrelétricas: um falso dilema entre desenvolvimento e direitos territoriais
Authors: Campoi Antonio Marcos , Ferrante Vera Lucia Silveira Botta , Junior Osvaldo Aly
Published: January 2023

A implantação de grandes empreendimentos hidrelétricos vem acompanhada de uma série de programas ambientais objetivando a prevenção, mitigação e compensação de seus impactos ambientais, econômicos, sociais e culturais na região de abrangência. Especificamente com relação ao remanejamento compulsório das famílias ocupantes das áreas de interesse destes empreendimentos, na ótica dos empreendedores este processo acarreta somente perdas materiais passíveis de serem indenizadas. Para as populações ribeirinhas a perda é do espaço onde os indivíduos travam suas relações pessoais e familiares, é o espaço de seu nascimento, de sua moradia, de sua reprodução social e cultural, é o local que exercem suas atividades produtivas temporárias em simbiose com o meio ambiente circundante, fatos estes que invariavelmente, não são considerados durante a realização dos estudos e relatórios de impacto ambiental e consequentemente nos processos mitigatórios e compensatórios a serem previstos. Este artigo visa analisar em um empreendimento hidrelétrico – UHE Peixe Angical no Estado do Tocantins, os efeitos e resultados de uma iniciativa pioneira que foi a criação de um espaço permanente de diálogo, o “Foro de Negociação” entre população atingida, órgãos licenciadores e fiscalizadores, empreendedor e poder público local. A partir dos resultados alcançados pelo Fórum e que foram analisados neste artigo, o  objetivo é propor que esta forma alternativa de licenciamento ambiental de grandes projetos possibilite a tomada de decisões de forma mais célere, rediscutindo ações, corrigindo rumos, adequando situações imprevistas, sempre amparadas nos interesses de todos os atores envolvidos direta e indiretamente na implantação do empreendimento, buscando reduzir ou minimizar os impactos causados as populações atingidas.
Pengaruh Pemberian Human Bone Marrow Mesenchymal Stem Cell Terhadap Gambaran Mikroskopis Jaringan Adneksa Pada Kulit Tikus Luka Bakar Diabetes Melitus
Authors: Wisesa Jella , Revilla Gusti , Yenita Yenita
Published: January 2023

Latar Belakang: Luka bakar pada kulit dapat mempengaruhi integritas kulit sesuai kerusakan yang terjadi, yaitu hilang atau tidaknya jaringan adneksa sebagai organ sensorik dan termoregulasi, sehingga menjadi salah satu parameter penyembuhan kulit. Kondisi diabetes melitus mengganggu proses penyembuhan luka melalui peningkatan stres oksidatif yang menyebabkan penurunan fungsi endotel sehingga memperpanjang fase inflamasi dan menghambat proliferasi. Human bone marrow mesenchymal stem cell (hBM-MSC) dapat mempercepat penyembuhan kulit dan pertumbuhan jaringan adneksa.
Objektif: Mengetahui pengaruh hBM-MSC terhadap gambaran mikroskopis jaringan adneksa pada kulit tikus luka bakar diabetes melitus
Metode: Penelitian ini menggunakan hewan percobaan yang diinduksi aloksan untuk menginduksi kerusakan sel-β pankreas, dibuat luka bakar dengan ketebalan penuh dengan plate yang dipanaskan. Penelitian eksperimental ini menggunakan 30 hewan coba yang dibagi menjadi 2 kelompok (Kontrol dan perlakuan) dan distratifikasi berdasarkan hari ke-3, ke-7, dan ke-14 yang terdiri dari 5 tikus per hari. Kelompok kontrol diberikan NaCl fisiologis, sedangkan perlakuan diberikan hBM-MSC.
Hasil: Hasil yang didapatkan adalah terjadi peningkatan jumlah total pertumbuhan jaringan adneksa kulit setelah diberikan hBM-MSC, tetapi tidak terlalu berpengaruh pada rata-rata diameter. Analisis uji Two-Way ANOVA menunjukkan tidak terdapat perbedaan yang bermakna untuk jumlah total dan rata-rata diameter pertumbuhan jaringan adneksa kulit dengan p berturut-turut 0.621 dan 0.427 (p > 0.05).
Kesimpulan: Kesimpulan yang didapat adalah hBM-MSC dapat memengaruhi pertumbuhan jaringan adneksa pada kulit tikus luka bakar diabetes mellitus, tetapi secara statistik menunjukkan hasil yang tidak signifikan.
Kata kunci: Diabetes melitus, human bone marrow mesenchymal stem cell (hBM-MSC), jaringan adneksa kulit, luka bakar.
Gambaran Pengetahuan, Sikap, dan Tindakan Mahasiswa Kesehatan di Kota Padang Mengenai Vaksin COVID-19
Authors: Anugrahwati Gustia , Elvira Dwitya , Yulistini Yulistini , Adrial Adrial , Hendriati Hendriati , Ilmiawati Cimi
Published: January 2023

Latar Belakang: Keraguan terhadap vaksin COVID-19 dan kurangnya pengetahuan mahasiswa kesehatan dapat mempengaruhi keberhasilan herd immunity sehingga dibutuhkan berbagai upaya untuk meningkatkan pengetahuan dan kesadaran akan pentingnya vaksinasi COVID-19.
Objektif: Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan, sikap dan tindakan mengenai vaksin COVID-19 pada mahasiswa kesehatan di Padang, Indonesia.
Metode: Penelitian ini merupakan penelitian deskriptif dengan desain cross-sectional menggunakan teknik consecutive sampling pada bulan Maret-April 2022 dan didapatkan sebanyak 350 responden yang berpartisipasi dalam penelitian ini. Data diperoleh dari kuesioner yang dibagikan melalui tautan Google form kemudian dianalisis menggunakan analisis univariat.
Hasil: Hasil penelitian menunjukkan sebanyak 58,6% responden memiliki pengetahuan yang baik, sebanyak 66,6% responden menunjukkan sikap positif dan sebanyak 52,9% responden menunjukkan tindakan yang cukup baik mengenai vaksin COVID-19.
Kesimpulan: Mayoritas mahasiswa kesehatan menunjukkan tingkat pengetahuan baik, sikap positif dan tindakan cukup baik terhadap vaksin COVID-19.
Los videojuegos educativos y las competencias digitales en la enseñanza de las ciencias
Authors: Cabrera Castillo Henry Giovany , Espinosa Ríos Andrés , Viáfara Ortiz Robinson , Barona Anggie Carolina , Escobar Buitrón Andres Felipe , Bermudez Diaz Juan David , Riascos Sarmiento Iveth Andrea , Barrera Moncada Juan Martín
Published: January 2023

En la actualidad los videojuegos educativos han adquirido un valor preponderante en los procesos educativos, siendo utilizados como instrumentos de aprendizaje. En este sentido, la finalidad de este libro consiste en realizar una conceptualización y caracterización de los videojuegos educativos y las competencias digitales, y establecer lineamientos metodológicos para el diseño de propuestas educativas para la enseñanza de las ciencias, específicamente, presenta unidades didácticas desde el campo de la biología y la física, donde se pretende abordar una serie de actividades fundamentadas en el desarrollo de competencias mediante el uso de videojuegos educativos. Los cuatro capítulos que hacen parte de este libro se estructuran así: los capítulos 1 y 2 son conceptualización de los principales términos que hicieron parte del proyecto en relación con los videojuegos, las competencias digitales y su papel en el ámbito educativo y se establecen los lineamientos metodológicos para el diseño de propuestas educativas basadas en el uso de videojuegos educativos y la manera como se promueven las competencias digitales. El capítulo 3 aborda una propuesta educativa desde campo disciplinar de la biología mediante la temática de la estructura y síntesis del ARN. Finalmente, el capítulo 4 presenta una propuesta de enseñanza desde el campo de la física (la electricidad y los circuitos eléctricos). Finalmente, el libro está dirigido principalmente a profesores de ciencias naturales tanto en formación inicial como en ejercicio que estén interesados en promover competencias digitales que permitan el potenciamiento en el aprendizaje de habilidades, destrezas, procesos cognitivos en sus estudiantes mediante el uso de videojuegos educativos.
اثر استراتيجية تدوين الملاحظات في تحصيل طالبات الرابع الأدبي في الأدب والنصوص
Authors: Mohsen Hoda Abdul Karim
Published: January 2023

هدف البحث إلى التعرّف على (أثر استراتيجية تدوين الملاحظات في تحصيل طالبات الرابع الادبي في الادب والنصوص). تكونت عينة البحث من (62) طالبة من طالبات الصف الرابع الادبي في مدرسة ثانوية للبنات في مدينة الرمادي / مركز محافظة الأنبار للعام الدراسي (2019 - 2020)، وزعن بالتساوي إلى مجموعتين: تجريبية وضابطة بواقع (31) طالبة في كل مجموعة، بعد ان كافأت الباحثة بينهما إحصائياً في مُتغيرات (العُمر الزمني، واختبار الذكاء، واختبار القدرة اللغوية، واختبار معلومات سابقة)، وقد أعدّت اختباراً للتحصيل من (40) فقرة موضوعية من نوع "اختيار من متعدد ذي الأربعة بدائل"، وقد تحققت من صدقه وثباته، وبعد انتهاء التجربة وتطبيق الاختبار على طالبات مجموعتي البحث أظهرت النتائج: يوجد فرق ذو دلالة إحصائية بين متوسط درجات طالبات المجموعة التجريبية اللواتي درسن باستراتيجية تدوين الملاحظات ومتوسط درجات طالبات المجموعة الضابطة اللواتي درسن بالطريقة الاعتيادية في اختبار التحصيل لصالح طالبات المجموعة التجريبية.
The Importance of Using Game Strategy in Teaching English Grammar
Authors: Sami Afraa Husam
Published: January 2023

English language plays an essential part in everyday situations over the world. It is a global language that transacts with all sides of life. So, all non-native learners must study the English language.

      Grammatical knowledge is considered a significant component of English language learning. It is a crucial mean in constructing confidence, fluency in using English language ( Sultan, 2012 : 1).

    English language teachers use many techniques and strategies to gain grammatical knowledge. One of these strategies is the Game strategy.  The game strategy presents entertaining drills and creates comfortable learning milieu. It invigorates stimulus among learners.

      This study is intended at defining the nature of game strategy that may develop learners’ grammar, specifying features of grammar that will be enhanced by employing the Game strategy and finally shedding light on the usefulness of Game strategy in improving students' grammar and defines to what extent it affects on language learning and using.                                              

     Presenting a theoretical background about the game strategy which affects the learning of grammar, introducing a literary review around the game strategy, about its definitions, features, and about its prominence in English language teaching especially in teaching grammar are the procedures which were followed by the researcher to achieve the aims of this study.
More Is Better: Acceptor Engineering for Constructing NIR-II AIEgens to Boost Multimodal Phototheranostics
Authors: Yang Shiping , Zhang Jianyu , Zhang Rongyuan , Ou Xinwen , Li Xue , Zhang Zhijun , Xu Weilin , Kang Miaomiao , Yan Dingyuan , Sun Jianwei , Lam Jacky W. Y. , Wang Dong , Tang Ben Zhong
Published: January 2023

The manipulation of electron donor/acceptor (D/A) shows endless impetus for innovating optoelectronic materials. Because of the diversity of electron-donating species, the study on donor engineering has explored systematically, whereas the research on electron acceptor engineering received a snub by contrast. Inspired by the philosophical idea of “more is different”, two systems with D'−D−A−D−D' (1A system) and D'−D−A−A−D−D' (2A system) structures based on the acceptor engineering are ingeniously designed and studied. It is demonstrated that the 1A system presents a weak aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ) phenomenon along with the increased acceptor electrophilicity. Interestingly, the 2A system exhibits an opposite ACQ-to-AIE transformation, manifesting the dual-acceptor tactic could facilitate AIE activity. Thanks to the highest molar absorptivity, near-infrared-II (NIR-II, 1000–1700 nm) emission, superior AIE effect, favorable reactive oxygen species generation and high photothermal conversion efficiency, a representative member of 2A system handily perform in fluorescence-photoacoustic-photothermal multimodal imaging-guided photodynamic-photothermal synergetic therapy for efficient tumor elimination. Meanwhile, NIR-II fluorescence imaging of blood vessels and lymph nodes in living mice are also accomplished. This work provides a fascinating molecular design philosophy for developing versatile phototheranostic agent with a higher molar absorptivity, superb aggregation-intensified NIR-II fluorescent emission, and improved heat generation capacity.
A reaction network of AP decomposition: the missing piece from atomic simulations
Authors: Chu Qingzhao , Fu Xiaolong , Chen Dongping
Published: January 2023

The decomposition network of AP is essential for the combustion performance and safety of solid propellants, while the detailed reaction pathway during thermolysis is far from clear due to the ultrafast and complex reactions involved. Herein, we present direct atomic simulations of AP thermal decomposition and propose a detailed decomposition network to fill the missing piece in the kinetics models, by using a neural network model derived from ab initio calculations. The proton transfer is the dominant channel (NH4 + ClO4 -> NH3 + HClO4), which is also observed in previous mass spectra experiments. In addition, gas products from decomposition play a critical role in promoting the decomposition of solid AP. For example, the H abstraction reaction by OH is found to be a critical pathway for AP decomposition. These simulations provide atomic insights into the complex reaction dynamics of AP and can be extended to investigate the reaction mechanism of novel energetic materials.
N-Terminal Proline Editing for the Synthesis of Peptides with Mercaptoproline and Selenoproline: Mechanistic Insights Lead to Greater Efficiency in Proline Native Chemical Ligation
Authors: Ludwig Brice , Forbes Christina , Zondlo Neal
Published: January 2023

Native chemical ligation (NCL) at proline has been limited by cost and synthetic access. In addition, prior examples of NCL using mercaptoproline have exhibited stalling of the reaction after thioester exchange, due to inefficient SN acyl transfer. Herein, we develop methods, using inexpensive Boc-4R-hydroxyproline, for the solid-phase synthesis of peptides containing N-terminal 4R-mercaptoproline and 4R-selenoproline. The synthesis proceeds via proline editing on the N-terminus of fully synthesized peptides on the solid phase, converting an N-terminal Boc-4R-hydroxyproline to the 4S-bromoproline, followed by SN2 reaction with potassium thioacetate or selenobenzoic acid. After cleavage from the resin and deprotection, peptides with functionalized N-terminal proline amino acids were obtained. NCL reactions with mercaptoproline proceeded slowly under standard NCL conditions, with the S-acyl transthioesterification intermediate observed as a major species. Computational investigations indicated that the bicyclic intermediates and transition states for SN acyl transfer are sufficiently low in energy (10-15 kcal mol–1 above starting material) that ring strain cannot explain slow SN acyl transfer. Instead, the bicyclic zwitterionic tetrahedral intermediate has a low barrier for reversion to the S-acyl intermediate, causing reversion to the thioester (reverse reaction) to occur preferentially over elimination to generate the amide (forward reaction). We hypothesized that a buffer capable of general acid and/or general base catalysis could promote SN acyl transfer, and thus achieve greater efficiency in proline NCL. In the presence of 2 M imidazole at pH 6.8, NCL with mercaptoproline proceeded efficiently to generate the peptide with a native amide bond. NCL with selenoproline also proceeded efficiently to generate the desired products when a thiophenol thioester was employed as a ligation partner. After desulfurization or deselenization, the products obtained were identical to those synthesized directly, confirming that the solid-phase proline editing reactions proceeded stereospecifically and without epimerization.
FINANCING RISKS AND COUNTERMEASURES IN REAL ESTATE INDUSTRY
Authors: Liu Yuwei
Published: January 2023

Under the supply-side regulation of the “The Three Red Lines”, loan concentration management, pre-sale fund supervision and other policies, the asset-liability ratio and net debt ratio of China’s real estate enterprises continues to improve. However, at the same time, there is a contrast between leverage ratio decline and risk increase, indicating that there’s still serious capital problem in the real estate industry, and the existing high-cost financing risks, high-leverage operation risks, high-proportion indirect financing risks, and high-probability overseas financing default risks have not been properly addressed. In the long run, it is necessary to strengthen the structural and long-term regulation of financing in the real estate industry, clarify the differences in risk degree of real estate enterprises, improve the stable expectations of participants in the real estate industry, and fundamentally solve the problems of high-cost financing and high-leverage operations. In the short term, it’s necessary to increase the direct financial support of high-quality real estate enterprises, standardize the external debt financing of real estate enterprises, and resolve the high-cost financing risks, high-proportion indirect financing risks and overseas financing default risks.
POPULATION DENSITY OF ARBUSCULAR MYCORRHIZAL FUNGI AND PHYSICO-CHEMICAL PROPERTIES OF SOILS AS AFFECTED BY CROPPING SYSTEMS
Authors: Thaddeus Egboka Nzube , Chimaobi Agim Leonard , Akaninyene Okon Michael , Henry Okoli Nnaemeka , Isaiah Afangide Akaninyene , Nkem Okonjo Philomena
Published: January 2023

Cropping pattern exerts significant impact on the population density of the arbuscular mycorrhizal fungi (AMF) and on soil properties. The study examined the population of indigenous AMF communities as well as status of soil properties under different cropping systems in Aluu, Rivers state, Nigeria. Two farm sites of mono cropping and mixed cropping systems and a fallow land (which served as control) were sampled at 0 – 20 cm depth of soil. Soil samples were analyzed in the laboratory for their physical and chemical properties as well as for the estimation of AMF spore density and resulting data were analyzed statistically. Result shows that, soils of the mono cropping and mixed cropping systems are moderately acidic with mean pH values of 5.80 and 5.74, respectively, while the fallow land exhibits a strongly acid soil reaction (pH = 5.29). Concentrations of organic C (9.25 g kg-1), total N (0.97 g kg-1), exchangeable Ca2+ (3.63 cmol kg-1), available P (13.31 mg kg-1) and C:N ratio (7.87) as recorded in the mixed cropping system, were generally higher than the corresponding results in the fallow and mono cropping systems. Spore population of the AMF varied significantly (P < 0.05) across the cropping systems and was highest in the mixed cropping (157 spores 100 g-1 soil) followed by the fallow (144 spores 100 g-1 soil) while the mono cropping (123 spores 100 g-1 soil) had the lowest spore density. Significant negative (P < 0.05) correlations occurred between AMF spore population and soil pH in both the fallow (r = 0.689*) and mixed cropping (-0.670*) systems whereas correlation with C:N ratio was positively significant (P < 0.01) across the cropping systems. Adoption of mixed cropping rather than mono cropping practices should be encouraged in the studied area in order to enjoy maximum benefits of mycorrhizal symbiosis.
A Meta-Analysis on the Correlation Between Herpes Simplex Virus Type II Infection and Adverse Pregnancy Outcomes in China
Authors: Wang Li , Yurong Zhang  , Xin Wang
Published: January 2023

Objective: To systematically evaluate the relationship between herpes simplex virus type II (HSV-2) infection in pregnant women and the adverse pregnancy outcomes (preterm delivery, spontaneous abortion, stillbirth, monstrum, low birth weight, intrauterine growth retardation, premature rupture of membranes), so as to provide clinical guidance for the prevention and treatment of adverse pregnancy outcomes caused by HSV-2 infection in pregnant women. Methods: 2140 articles were collected from PubMed, China National Knowledge Infrastructure (CNKI), and other databases for the past 20 years. According to the inclusion criteria, the literatures about the relationship between HSV-2 infection of pregnant women and adverse pregnancy outcomes were screened. The effect model was determined by heterogeneity test results, and the meta-analysis was carried out by RevMan 5.3 software. Results: The results of meta-analysis showed that the positive rate of HSV-2 was higher in the adverse pregnancy group than in the control group (odds ratio [OR]: 7.92, 95% confidence interval [Cl]: 3.91–16.01), and the difference was statistically significant. Conclusion: HSV-2 infection will increase the risk of adverse pregnancy outcomes. Prevention and effective control of HSV-2 infection in early pregnancy can reduce the rate of adverse pregnancy outcome, which is of great significance to the promotion of eugenics.
Diagnostic Value and Misdiagnosis Analysis of Conventional Ultrasonography Combined with Contrast-Enhanced Ultrasonography in Thyroid Nodules
Authors: He Meiqing , Zhang Xixi , Li Hui , Wang Tian
Published: January 2023

Objective: To explore the diagnostic value of conventional ultrasonography combined with contrast-enhanced ultrasonography in thyroid nodules. Methods: From June 2021 to July 2022, 163 patients with thyroid nodules enrolled in our hospital were selected as research subjects. After pathological diagnosis, 24 cases were malignant thyroid nodules, and 139 cases were benign thyroid nodules. The diagnosis rate of malignant and benign thyroid nodules was observed and analyzed, with 95% CI. Results: Among them, the malignant and benign detection rates of routine ultrasound were 88.63% and 75.00%, respectively, and the malignant and benign detection rates of contrast-enhanced ultrasound were 81.82% and 81.25%, respectively. The malignant and benign detection rates of conventional ultrasound combined with contrast-enhanced ultrasound were 93.18% and 87.50%, respectively, and the 95% CI was greater than 0.7. Conclusion: Conventional ultrasound combined with contrast-enhanced ultrasound can help improve the diagnostic accuracy of benign and malignant thyroid nodules and reduce the misdiagnosis rate.
Forecast of the digitalization impact on public ﬁnancial management
Authors: Belousov Yu. V. , Timofeeva O. I.
Published: January 2023

Modern digital technologies based on artiﬁcial intelligence and big data have a signiﬁcant impact on many areas of the socioeconomic life of society. At present, digitalization has not affected the public ﬁnancial management system to a small extent. However, this particular area has a high potential for the use of big data and artiﬁcial intelligence, as it is based on signiﬁcant amounts of information, including unstructured information. At the same time, the process, mechanism and forms of the digital technologies impact on public ﬁnance management have been little studied in the scientiﬁc literature. The paper forecasts changing in the public ﬁnancial management system that may occur under the inﬂuence of digital technologies in the medium and long term. The authors used a methodical approach based on extrapolation for forecasting. Nowadays, digital technologies have signiﬁcantly inﬂuenced some sectors of the socio-economic people’s activity. The forms and mechanisms of such inﬂuence had been extrapolated to the public ﬁnancial management system and, primarily, to various stages of the budget process.
Anti-russian sanctions impact: aftermath of a reduction in foreign trade and production growth in the Russian Federation
Authors: Kazantsev S. V.
Published: January 2023

There are technological, economic, transport links in the production, storage and delivery of goods in the contemporary economy. Therefore, the appearance of a new or an increase in the volume of production of an existing product requires changes in the production of other products, linked with this one through the technological chains. Statistical data and models of input-output balance allow us to trace such chains of connections and calculate the volumes production of different goods. This paper contains the results of a study of intersectoral chains of inﬂuence of bans and restrictions imposed on Russian exports. The study shows the reduction in the export of some goods has a negative effect on the output of a number of other goods. The decrease in imports has a similar effect. The author also shows calculations’ results of the growth impact on the output of different goods and services on changes in the scale of other types of goods production and services in the Russian economy.