bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Microstructural White Matter Changes of Somatosensory Cortex in Stress Among Non-Clinical Population: A Diffusion Tensor Imaging Study
Authors: Zolkefley Mohd Khairul Izamil , Abd Razak Wan Adibah Nadiah , Perisamy Rajeev Shamsuddin , Zulkifli Nor Saradatul Akmar , Abdul Basit Khairul Salleh , Mustapha Muzaimi
Published: October 2024

Introduction: Stress is a common response to stressors or potential threats, resulting in physical, affective, and cognitive changes. Emotions are linked to interpretations of bodily alterations, with the somatosensory cortex, including the postcentral gyrus, playing a key role in emotional processing. This study aimed to investigate the relationship between stress and microstructural white matter changes in the somatosensory cortex among healthy adults, crucial for early detection and treatment of stress in non-clinical populations.
Materials and Methods: A total of 30 participants were recruited. The participants were administered the Depression, Anxiety, and Stress Scale 21 (DASS-21) questionnaire. All subjects underwent MRI brain scanning, with diffusion tensor imaging (DTI) used to assess white matter integrity. The association between stress scores in DASS-21 and DTI parameters was analyzed.
Results: A significant negative correlation between stress scores and fractional anisotropy (FA) values in the left postcentral gyrus (r = -0.393, p = 0.32) was found, indicating early impairment by stress. No significant correlation was found in the right postcentral gyrus (r = -0.300, p = 0.107).
Conclusion: Our research results demonstrated that the microstructural somatosensory cortex, especially the left postcentral gyrus, might have early changes impairment by stress using the technique of diffusion tensor imaging (DTI). Therefore, the microstructural white matter changes in the brain before suffering the disorder may be crucial and can be a novel potential biomarker for the early detection and intervention of the disease in the non-clinical population.
Vaping as a Harm Reduction Strategy: Lessons from the Past
Authors: Ab Rahman Prof. Dr. Jamalludin
Published: October 2024

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The concept of a smart contract: advantages and current situation of legal regulation in the Republic of Kazakhstan
Authors: Boranbay S.S. , Juchnevicius E.
Published: October 2024

This scientific article outlines the current provisions of the legal regulation of smart contracts, the relevance of which will grow as such contracts spread in various spheres and areas of life. Thus, the main problem of regulating relations on the use of a smart contract is the ambiguity of its legal essence, the lack of regulation in legislation, including in the Civil Code of the Republic of Kazakhstan. At the same time, some advantages of a smart contract are clearly shown by examples, which will help facilitate the process of concluding, changing, terminating and executing contracts. The main advantages of a smart contract are also discussed in detail, such as automation, transparency, security, efficiency, low intermediary costs, decentralization, flexibility and programmability. In the research, the authors touched upon the problems of fulfilling obligations in debt relations, the potential advantages and assistance of a smart contract in enforcement proceedings. The result of the exploration is a formulated definition of a smart contract and the identification of specific potential advantages of this type of non-traditional contracts. The authors summarize the results, noting the absence of a legal definition of a smart contract in the legislation of the Republic of Kazakhstan, the exclusively declarative nature of its legal regulation; the ambiguity of the range of public relations where contracts in this form are applicable, which does not allow the widespread dissemination and use of a smart contract.
Developing podcast for listening material for grade 10
Authors: Anggriani Titania , Elfiza Rona , Candra Muhammad
Published: October 2024

This study aimed to developedpodcast for listening material for grade 10. The subject of this research was the tenth grade, which consisted of 22 students. The location of this research was in the MAN Tanjungpinang. The type of this research was development research with ADDIE model. The researcher focused on developing podcast for listening matrial that was suitable for studentsÃ¢â‚¬â„¢ daily activity and their environment. There were five stages namely analysis, design, development, implementation and evaluation. The data obtained from studentsÃ¢â‚¬â„¢ need questionnaires, expert validation questionnaire, and small group try out questionnaire. The results showed that the podcast validation results for students' listening material for class X were valid and did not need revisions. Podcasts were directly implemented to students. Based on the results of student implementation of the practicality test sheet, it was found that podcasts for listening material for grade 10 were very appropriate and practical.
Justicia restaurativa para el tratamiento de conflictos de acoso sexual, violencia y discriminación en los establecimientos universitarios
Authors: González Ramírez Isabel Ximena
Published: October 2024

Introducción: En las universidades, los conflictos de acoso sexual, violencia y discriminación de género son comunes, afectando a estudiantes que a menudo son víctimas silenciosas. Este artículo analiza la posible aplicación de un sistema restaurativo para abordar estos conflictos dentro de la comunidad universitaria. Metodología: Se utilizó una metodología cualitativa con un diseño descriptivo y evidencia empírica para investigar la viabilidad de un enfoque restaurativo en el tratamiento de estos conflictos. Resultados: Los resultados indican que existen factores que permiten la incorporación de un tratamiento restaurativo para los conflictos de acoso sexual, violencia y discriminación de género en la universidad. Este enfoque podría contribuir a crear un ambiente más propicio para el aprendizaje. Discusión: Aunque las políticas, reglamentos y comisiones de ética representan un avance en la materia, no siempre proporcionan resultados preventivos ni soluciones reparadoras satisfactorias para las víctimas, dado su enfoque sancionatorio. Conclusiones: Un sistema restaurativo podría ofrecer soluciones más reparadoras y satisfactorias en los conflictos de acoso, violencia y discriminación de género en la comunidad universitaria, mejorando el ambiente educativo.
Recrear los espacios educativos: espacios de relación que educan y aprenden
Authors: Guillem González-Blanch María
Published: October 2024

Introducción: Este artículo examina si la arquitectura puede favorecer las relaciones que facilitan el aprendizaje en una comunidad educativa, argumentando que la arquitectura educa y aprende, al adaptarse a las necesidades del alumnado y docentes, con un enfoque pedagógico. Metodología: La investigación utiliza un estudio de casos de arquitectura educativa marianista, que se basa en lo relacional. Se analizan tanto proyectos nuevos como intervenciones en construcciones existentes y ampliaciones, adaptadas a las diferentes formas de aprender de los estudiantes. Resultados: El análisis demuestra que centrar las decisiones arquitectónicas en la relación del alumnado con la comunidad educativa tiene un impacto positivo y decisivo. La versatilidad de los espacios refleja una adaptación al cambio, basada en la reflexión de toda la comunidad educativa. Discusión: Las decisiones intencionadas sobre el diseño de los espacios, traducidas por arquitectos especializados, propician relaciones que educan, fomentando la participación activa y crítica del alumnado en la comunidad. Conclusiones: La arquitectura educativa, cuando se centra en lo relacional, fomenta un entorno que no solo facilita el aprendizaje, sino que también prepara a los estudiantes para participar activamente en el cambio social.
Experiencias de líderes víctimas del conflicto armado frente a procesos de atención psicosocial en el municipio de Chalán
Authors: Hernandez Henrriquez Cindy Paola
Published: October 2024

Introducción: El conflicto armado ha dejado un impacto significativo en la población colombiana, destacando las afectaciones psicológicas que han requerido de la implementación de procesos de atención y acompañamiento psicosocial. Este estudio analiza los procesos de atención psicosocial en el municipio de Chalán desde la experiencia de los líderes comunitarios. Metodología: Desde un enfoque cualitativo fenomenológico, se implementaron grupos focales donde participaron 35 líderes y lideresas. Resultados: Los resultados revelaron inconformidades debido a la ausencia, insuficiencia o deficiencia de las acciones estatales en materia de atención psicosocial. Entre las expresiones destacadas se encuentran: "En el territorio, los procesos psicosociales que se han llevado a cabo han sido escasos, desarrollados a través de talleres grupales que no satisfacen las necesidades de salud mental de la comunidad"; "Vienen hacer acción con daño, por eso recomendamos que los procesos de atención psicosocial deben ser íntegros, constantes y permanentes", "No tienen en cuenta el enfoque diferencial”. Discusión: Los hallazgos subrayan la necesidad de implementar intervenciones psicosociales integrales con un enfoque diferencial, que involucre la participación de la comunidad, los líderes, las entidades públicas y privadas, garantizando el fortalecimiento del bienestar psicológico, subjetivo, social y promoviendo el desarrollo social.
Stereotactic radiofrequency lesioning of caudal zona incerta for parkinsonian tremor
Authors: Bajaj Jitin , Khandelwal Namrata , Jain Anivesh , Swamy Muddaiah N. , Yadav Yad R.
Published: October 2024

This video showcases stereotactic radiofrequency lesioning of the caudal zona incerta (CZi) for parkinsonian tremor in a 70-year-old patient. The preoperative evaluation, including imaging and frame placement, is detailed. The surgical procedure involves meticulous targeting and trajectory planning. Intraoperative stimulation is utilized for motor response assessment. Two temporary lesioning phases precede the final procedure at 75°C. The postoperative CT scan highlights the lesion site. Immediate tremor relief is observed postoperatively, with the effect persisting at the 1-month follow-up. Supporting readings underscore the efficacy and safety of CZi for tremor management.

The video can be found here: https://stream.cadmore.media/r10.3171/2024.7.FOCVID2462
MRI-guided focused ultrasound for essential tremor
Authors: Agopyan-Miu Alexander H. , Simmons Grace B. , Baltuch Gordon H.
Published: October 2024

This video depicts a left-sided MRI-guided focused ultrasound (MRgFUS) thalamotomy for a right-arm tremor in a 76-year-old, right-handed man with bilateral upper-extremity tremors. The patient tolerated the procedure well, with immediate tremor reduction that persisted at the 1-month follow-up, and there were no adverse events noted during intraoperative testing, postoperative testing, or follow-up. This case highlights MRgFUS as an effective, safe, incision-free treatment option for medically refractory essential tremor. Additional research is required to establish the long-term efficacy of MRgFUS compared with other surgical treatment options such as deep brain stimulation (DBS) and radiosurgery.

The video can be found here: https://stream.cadmore.media/r10.3171/2024.7.FOCVID2472
Magnetic resonance–guided focused ultrasound thalamotomy for tremor
Authors: Chen Jason A. , White P. Jason , Cosgrove G. Rees , Rolston John D.
Published: October 2024

Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy has emerged as an effective treatment for tremor, particularly in those patients who are excluded from deep brain stimulation. The authors illustrate an example of MRgFUS thalamotomy, targeting the ventralis intermedius nucleus, in a 78-year-old patient with tremor who had features of essential tremor and tremor-predominant Parkinson’s disease. Significant tremor improvement was seen during the procedure. The authors review step-by-step the preoperative considerations, Vim targeting, treatment, and outcomes for this evolving treatment modality.

The video can be found here: https://stream.cadmore.media/r10.3171/2024.7.FOCVID249
Habilitacyjne perypetie lubelskiego historyka prawa doktora Jana Kamińskiego
Authors: Jońca Maciej
Published: October 2024

Pod koniec lat 20. XX w. Katolicki Uniwersytet Lubelski podjął starania w kierunku umożliwienia uzyskania habilitacji przez historyka prawa – doktora Jana Kamińskiego. Przedsięwzięciu temu sprzyjał prof. Przemysław Dąbkowski, który był mentorem i wychowawcą Jana Kamińskiego. Niestety, mimo wieloletnich starań, lubelskiemu uczonemu nie udało się zdobyć upragnionego tytułu. Materiały archiwalne, zachowane w zbiorach Biblioteki KUL, rzucają nowe światło na tę sprawę. Nie wszyscy byli Kamińskiemu życzliwi i nie wszyscy dotrzymali słowa, obiecawszy mu wsparcie i pomoc.
Magia w Kazaniach Cezarego z Arles
Authors: Stodulska Irmina
Published: October 2024

Cezary z Arles był jedną z najwybitniejszych postaci swoich czasów. Starał się wpływać na postępowanie podległej mu społeczności poprzez żarliwe i głęboko przemyślane kazania. Jednymi z poruszanych w nich zagadnień były różnego rodzaju praktyki magiczne. Duchowny piętnował m.in.: wróżenie z wnętrzności zwierząt (haruspicia), wróżenie z zachowania ptaków (auguria) czy astrologię, a także zwracanie się do zamawiaczy, czarnoksiężników, wróżących z losów oraz wieszczków. Zdaniem biskupa Arles wszelkiego typu magiczne aktywności łączyło jedno – związek z działalnością diabła. Przedmiotem prowadzonych w niniejszym artykule rozważań są praktyki magiczne, które w Kazaniach galijskiego kaznodziei zostały uznane za szkodliwe. Zastosowano metody historyczną, porównawczą i filologiczną.
Prawa auguralne i pontyfikalne w Noctes Atticae Aulusa Gelliusa
Authors: Zabłocki Jan
Published: October 2024

W archaicznym zbiorze Noctes Atticae Aulusa Gelliusa znalazły się ‒ wśród wielu ciekawych wiadomości, z różnych dziedzin wiedzy z minionej przeszłości, także te traktowane przez współczesnych mu jako bezużyteczne lub trudne do zrozumienia ‒ nieliczne wzmianki poświęcone rzadko poruszanym zagadnieniom prawa auguralnego i pontyfikalnego. Dzięki Gelliusowi zachowały się fragmenty zaginionych dzieł różnych autorów, które dotyczą, kompetencji kapłanów i ich udziału w obrzędach sakralnych takich jak: auspicia, adrogatio, testamentum calatis comitiis, inaugurationes regum et pontificum, captio dziewcząt do służby świątyni Westy, formuła iusiurandum żołnierzy i te wygłaszane przez fecjałów związane z przygotowaniem do wojny.
Mariology in the Documents of Ecumenical Dialogue and Christian Unity
Authors: Napiórkowski Andrzej
Published: October 2024

Ecumenical dialogues that seek to bring all followers of Christ closer to unity face many difficulties. One of them is the wrong understanding of ecumenism (doctrinal, spiritual and practical). Also an obstacle is the lack of distinction between the unity of Christians and the unity of the Churches. This article undertakes the presentation of another such difficulty in the path of Christian unity, which is the Mariological (doctrinal) and Marian (worship/devotion) issues. Ecumenical meetings, therefore, do not avoid such difficult topics concerning the Mother of the Lord, such as her virginity, Immaculate Conception, Assumption or her role as Mother of the Church. Many Christian traditions have different interpretations of these truths. Catholic and Orthodox communities even consider them an inalienable part of their spiritual heritage, while most Protestant communities have a more nuanced approach and do not accept these truths as binding, but reject them. A compilation of the documents to date relating to the Mother of God proves to be a big, positive surprise. Of course, these are writings of varying degrees of validity, as they come as much from international mixed official commissions as from national bilateral bodies or local debates. Nevertheless, both their prominence and impact, as well as their quantity, make it clear that the person and action of the Mother of Jesus nevertheless animates and strengthens the difficult rapprochement of the followers of her Divine Son.
Średniowieczne "clausulae" różańcowe i ich teologiczna treść
Authors: Lekan Janusz
Published: October 2024

Celem tej refleksji teologicznej jest skupienie się na jednej z form kultu maryjnego, jaką jest różaniec. Modlitwa ta, znana od wieków, posiada bogate znaczenie teologiczne – wprowadza w misterium zbawienia (doktryna) i stanowi rodzaj modlitwy medytacyjnej (duchowość). Jest modlitwą, która potrzebuje również odnowy, do czego zachęca papież Paweł VI w adhortacji Marialis cultus. Jedną z dróg odnowy tej modlitwy mogą stać się średniowieczne formy klauzuli różańcowych. Zanim jednak zostanie ukazany historyczny i teologiczny kontekst jej powstania, trzeba wskazać na naturę kultu maryjnego i jego miejsce w pobożności chrześcijańskiej. Po omówieniu kontekstu historyczno-teologicznego powstawania klauzul i roli Dominika z Prus w tym procesie, zechcemy podkreślić aktualność tej modlitwy, wskazując na jej bogactwo teologiczne – wartość biblijną i kontemplacyjną. Różaniec klauzulowy ma również wartość ekumeniczną, gdyż ta forma modlitwy posiada ściśle biblijne korzenie, zawiera bowiem Pozdrowienie anielskie, opisane w Ewangelii św. Łukasza i odniesienie do tajemnic zbawienia dokonanego przez Jezusa Chrystusa. Jest także odpowiedzią na modę medytacji religii Wschodu.
Mariologia Franciszka Petrarki w pieśni "Vergine bella, che di sol vestita"
Authors: Waszkiewicz Piotr Tadeusz
Published: October 2024

Petrarka często jest przeciwstawiany „Boskiemu Poecie”, Dantemu; jego poezja skupia się na figurze Laury oraz na miłości do niej, tym samym odchodząc od teocentryzmu średniowiecznego. Żyjący na granicy dwóch epok Petrarka wytyczał jednak pewne trendy nie tylko literackie, ale również teologiczne. Jego zbiór poezji wieńczy pieśń będąca mariologiczną perłą poezji średniowiecznej. Niniejszy artykuł pragnie pochylić się nad teologicznym aspektem poezji Petrarki w pieśni Vergine bella, che di sol vestita, próbując odkryć, jakim teologiem – i mariologiem – był Petrarka. Szczególnie ważne jest pytanie, czy jego maryjna pieśń jest odejściem od jego wcześniejszej perspektywy antropocentrycznej i ziemskiej oraz w konsekwencji, czy dzieło to stanowi polemikę, czy raczej punkt spotkania z Dantem. Odpowiedzi na te pytania służy poznanie prawdopodobnego kontekstu powstania Vergine bella, oraz przede wszystkim analiza wybranych wezwań pieśni, pozwalająca odkryć nawiązania do autorów wcześniejszych (od epoki patrystycznej po Franciszka z Asyżu i Dantego) oraz oryginalny wkład samego Petrarki, który – fundamentalnie wierny swojemu podejściu antropocentrycznemu – dostrzega w Maryi „Dziewicę ludzką” i szczególnie litościwą wobec ludzkiej nędzy. To właśnie tytuł Vergine humana wydaje się stanowić najbardziej oryginalną nutę mariologii Petrarki, a zarazem interesujący punkt jego wyjścia naprzeciw Dantemu.
Mujeres ‘en’ migración entre México y Estados Unidos. De la administración a la generación y remeseo de recursos propios, 1965–2008
Authors:   Universidad Nacional Autónoma de México, Córdoba Ramírez Diana , Hernández Lara Itzel ,   Universidad Autónoma del Estado de México
Published: October 2024

From a multidisciplinary perspective, this article proposes the concept of 'women "in" international migration' in order to acknowledge the specificities and diverse experiences that women have encountered in migratory processes. Specifically, we examine the women’s participation in the processes of generating, sending, receiving, and managing remittances between Mexico and the United States from 1964 to 2008. This research was conducted based on statistical data, documentary testimonies, and interviews that collectively highlight the significance of their gender condition.
Analisis Penerapan Audit Internal Pada Koperasi Unit Desa (KUD) Dwi Tunggal Tania Makmur
Authors: Fatmawati Siti , Arafat Yasir , Salmah Ninin Non Ayu
Published: October 2024

ABSTRACT
This study aims to determine the application of internal audit to cooperative compliance according to the Ministry of Cooperatives and UMKM Regulation Number 5 of 2016. The population of this study is a report on findings and the sample of this research is audit results in 2019-2021. The data collection technique for this research was a qualitative descriptive technique which was carried out by means of documentation and interviews. The data used are primary data and secondary data. The results of the study show that the cooperative has not fully complied with the regulations that have been set by conducting an internal audit to find out the weaknesses or deficiencies that exist in the cooperative and can comply with the regulations that have been set. The principle of cooperatives, cooperatives have been managed democratically, membership is voluntary and open, the distribution of the remaining business results is carried out fairly, and the development of cooperatives. Business, cooperatives have not been optimal in carrying out business performance, business planning and control, and financial control, KUD Dwi Tunggal has not complied with controls in its business. Transactions have not been carried out optimally by utilizing services, applying a standard accounting system, and KUD Dwi Tunggal has not fully complied with SAK-ETAP which can be seen from the accumulation of depreciation has not been carried out.
Keywords: Internal Audit,Compliance, Cooperatives.
 
ABSTRAK
Penelitian ini bertujuan untuk mengetahui penerapan audit internal pada kepatuhan koperasi sesuai Peraturan Kementrian Koperasi dan UMKM Nomor 5 Tahun 2016. Populasi penelitian ini adalah laporan hasil temuan dan sampel penelitian ini adalah hasil audit pada tahun 2019-2021. Teknik pengambilan data penelitian ini adalah teknik deskriptif kualitatif  yang dilakukan dengan dokumntasi dan wawancara. Data yang digunakan yaitu data primer dan data sekunder. Hasil penelitian menunjukkan bahwa koperasi belum sepenuhnya mematuhi peraturan  yang telah ditetapkan dengan dilakukannya audit internal dapat mengetahui kelemahan atau kekurangan yang ada pada koperasi dan dapat mematuhi peraturan yang telah ditetapkan. Prinsip koperasi, koperasi telah melakukan pengelolaan dilakukan secara demokratis, kenggotaan sukarela dan terbuka, pembagian sisa hasil usaha dilakukan secara adil, dan pengembangan koperasi. Usaha, koperasi belum optimal dalam menjalankan kinerja usaha, perencanaan dan pengendalian usaha, dan  pengendalian keuangan, KUD Dwi Tunggal belum mematuhi pengendalian dalam usahanya. Transaksi belum dilakukan secara optimal pemanfaatan pelayanan, penerapan sistem standar akuntansi, dan KUD Dwi Tunggal belum sepenuhnya mematuhi SAK-ETAP yang dapat dilihat dari belum dilakukannya akumulasi penyusutan.
Kata kunci: Audit Internal, Kepatuhan, Koperasi.
Analisis Pengelolan Aset Tetap Pada Kantor Camat Kecamatan Banyuasin II Kabupaten Banyuasin
Authors: Amanda Nurulia Putri , Nurmala Nurmala , Sudiyanto Totok
Published: October 2024

ABSTRACT
This study aims to analyze the management of fixed assets at the District Office of Banyuasin II District, Banyuasin Regency, especially in the recognition, measurement, valuation and disclosure of fixed assets. The population of this research is the Fixed Assets Management in the Banyuasin II District Head Office, Banyuasin Regency. This research method uses descriptive qualitative where the analysis process is by compiling and analyzing regional fixed asset management. The data used is secondary data that is already available and has been collected at the District Office of Banyuasin II District, Banyuasin Regency. The results of this study concluded that the management of fixed assets, especially in the recognition, measurement, valuation and disclosure of fixed assets at the Banyuasin II Subdistrict Head Office, Banyuasin Regency, was in accordance with the Statement of Government Accounting Standards (PSAP) Number 07 concerning Accounting for Fixed Assets which had been carried out optimally.
Keywords: Disclosure, Measurement, Valuation, Recognition, Fixed Assets.
 
ABSTRAK
Penelitian ini bertujuan untuk menganalisis pengelolaan aset tetap pada Kantor Camat Kecamatan Banyuasin II Kabupaten Banyuasin khususnya dalam pengakuan, pengukuran, penilaian dan pengungkapan aset tetap. Populasi penelitian ini adalah Pengelolaan Aset Tetap yang ada diKantor Camat Kecamatan Banyuasin II Kabupaten Banyuasin. Metode penelitian ini menggunakan deskriptif kualitatif dimana proses analisa dengan cara menyusun dan menganalisa pengelolaan aset tetap daerah. Data yang digunakan yaitu data sekunder yang sudah tersedia dan telah dikumpulkan pada Kantor Camat Kecamatan Banyuasin II Kabupaten Banyuasin. Hasil penelitian ini menyimpulkan bahwa pengelolaan aset tetap khususnya dalam pengakuan, pengukuran, penilaian dan pengungkapan aset tetap pada Kantor Camat Kecamatan Banyuasin II Kabupaten Banyuasin sudah sesuai dengan Pernyataan Standar Akuntansi Pemerintah (PSAP) Nomor 07 tentang Akuntansi Aset Tetap telah terlaksanakan dengan optimal.
Kata kunci: Pengungkapan, Pengukuran, Penilaian, Pengakuan, Aset Tetap.
СТРУКТУРНІ КОМПОНЕНТИ ГОТОВНОСТІ МАЙБУТНІХ УЧИТЕЛІВ ОБРАЗОТВОРЧОГО МИСТЕЦТВА ДО ВИКОРИСТАННЯ АРТ-ТЕХНОЛОГІЙ У ПРОЦЕСІ ПРОФЕСІЙНОЇ ПІДГОТОВКИ
Authors: Лей Лю
Published: October 2024

Стаття присвячена виокремленню структурних компонентів готовності майбутніх учителів образотворчого мистецтва до використання арт-технологій у процесі професійної підготовки з метою подальшого дослідження реального стану сформованості готовності у майбутніх учителів образотворчого мистецтва до використання арт-технологій. Обґрунтовано багатоаспектність та складність вирішення проблеми формування готовності майбутніх учителів образотворчого мистецтва до використання арт-технологій у процесі професійної підготовки. Було визначені ознаки готовності до педагогічної діяльності майбутніх учителів.
В результаті було запропоноване власне бачення структури готовності майбутніх учителів образотворчого мистецтва до використання арт-технологій в процесі професійної підготовки, яка складається з чотирьох взаємопов’язаних компонентів, а саме: ціннісно-мотиваційний, змістовний, комунікативно-діяльнісний та особистісно-регулятивний. Ціннісно-мотиваційний компонент передбачає усвідомлення ставлення майбутніх учителів образотворчого мистецтва до використання арт-технологій, що визначає спрямованість майбутніх учителів образотворчого мистецтва на використання арт-технологій. Сформованість змістовного компоненту свідчить про розвиток інтелектуальної активності майбутніх учителів, наявність у них власного особистісного потенціалу до використання арт-технологій у майбутній професійній діяльності. Комунікативно-діяльнісний компонент проявляється в наявності організаційних, розвиваючих і комунікативних компетентностей, а також умінь та навичок володіння арт-технологіями як системою інваріантних педагогічних умінь по вирішенню педагогічних завдань. Особистісно-регулятивний передбачає здатність до саморегуляції у процесі використання арт-технологій у педагогічній діяльності, самоконтроль і професійну самооцінку.
Biological active compounds from edible mushroom: Effect on hela cells
Authors: Avagyan Inesa , Minasbekyan Liya , Nanagulyan Siranush
Published: October 2024

Background: Mushrooms are unique organisms rich in proteins, carbohydrates, vitamins, and minerals, which allows them to be used not only as a source of nutrition but also in cosmetics and medicine. The fungus P. ostreatus possesses two strong enzymatic complexes – lignin-decaying and cellulose-decaying. 
Objective: The research aimed to study the antitumor activity of treated mm-wave mycelial extracts of mushrooms on the HeLa cell line. Research on edible mushrooms against tumors is very actual and important for the field of functional food science and bioactive compounds field.
Methods: The effect of the fungal culture extract on the cyto-photometric and morphometric indices of the HeLa cell line culture was studied according to the nature of proliferation and transcription of malignant tissues. Using high-resolution liquid chromatography, the amino acid composition of acid-soluble proteins in mycelial extracts of a mushroom culture treated with mm waves was studied.
Results: Extracts of P. ostreatus mycelial culture significantly suppressed the growth of proliferative activity of human tumor cultures and completely suppressed the mitotic activity of continuous HeLa cell cultures to 72 hours. Our study revealed a significant increase in glutamic and aspartic acids in mycelial culture extracts treated by mm-waves.
Conclusion:  Based on HPLC analysis, we suggest polyfunctional peroxidase as the candidate for the role of biologically active compound in the composition of aqueous extracts of the mycelial culture. So, the polyfunctional peroxidase plays an active role in the therapeutic properties of the oyster mushroom.
Keywords: anticancer activity, ant-inflammation activity, mm-waves, mushroom`s, mycelial extracts, HPLC of acid-soluble proteins, HeLa cell line.
Preparation and Characterization of Isradipine as Surfactant-Free Dry Emulsion
Authors: Al-Sharify Zahraa M. , J. Jawad Fatima
Published: October 2024

Background: Oral anticoagulation medication, warfarin, and non-vitamin K antagonist oral anticoagulants (NOAC) may require long-term use which may affect patients’ satisfaction with their treatment and their quality of life (QOL).
Objective: To compare the quality of life and treatment satisfaction among groups of patients using different anticoagulant therapies (warfarin and NOAC). 
Methods: A cross-sectional study was performed at Ibn Al-Bitar Hospital for cardiac surgery in Baghdad in the period from December 2022 to May 2023. The study population included a convenient sample of patients receiving either warfarin or non-vitamin k antagonist oral anticoagulants treatment. The Arabic version of the short form 12 (SF-12) questionnaire and the Anti-Coagulant Treatment Satisfaction Scale (ACTS) questionnaire were used to assess the quality of life and satisfaction with treatment respectively. 
Results: The study included 181 patients in total. The mean physical and mental quality of life scores for study participants were 42.3±9.92 and 52.6±10.36 respectively. There was no significant difference in the QOL between patients taking warfarin and those on non-vitamin k antagonist oral anticoagulant treatment. The mean total satisfaction score was 65.4±6.73. Patients receiving non-vitamin k antagonist oral anticoagulants had significantly higher satisfaction compared to those receiving warfarin. The physical score correlated significantly with gender, educational level, employment status, number of chronic medications, and number of chronic diseases. The total satisfaction score correlated significantly with gender, number of chronic medications, number of side effects, and duration of anticoagulation. There was a significant correlation between the QOL and treatment satisfaction.
Conclusion: Treatment with non-vitamin K antagonist oral anticoagulants showed comparable QOL and higher treatment satisfaction than that of warfarin. Better treatment satisfaction can improve patients’ QOL which may ultimately enhance their adherence to treatment.
Assessment of Serum P53 Protein Level in Adult Patients with Acute Myeloid Leukemia in Correlation with Response to Treatment
Authors: Jebur Laith A. , Al-Rubaie Haithem A.
Published: October 2024

Background: Acute myeloid leukemia (AML) is an adult leukemia characterized by rapid proliferation of undifferentiated myeloid precursors, leading to bone marrow (BM) failure and impaired erythropoiesis. The p53 tumor suppressor protein regulates cell division and inhibits tumor development by preventing cell proliferation of altered or damaged DNA. It orchestrates various cellular reactions, including cell cycle arrest, DNA repair, and antioxidant properties.
Objectives: To investigate the relationship of P53 serum level with hematological findings, remission, and survival status in de novo AML patients.
Methods: This is a cross-sectional study that enrolled 63 newly diagnosed de novo AML patients, and 15 sex- and age-matched healthy persons as a control group. Serum P53 levels were assessed using the enzyme-linked immunosorbent assay (ELISA) technique before initiating induction chemotherapy. The study was performed between November 2022 and May 2023 at the Hematology and Bone Marrow Transplant Center of the Medical City Complex in Baghdad.
Results: There were significantly lower P53 serum levels in AML patients before starting chemotherapy compared to the control group. However, no substantial difference in P53 levels was identified between AML patients achieving complete remission and those exhibiting no response, nor between alive and deceased individuals. Furthermore, there was a positive yet statistically non-significant correlation between serum P53 levels and age, and no significant relationship between P53 levels and sex or various hematological parameters.
Conclusion: P53 levels are low in AML patients. They are not associated with remission status or survival after six months and are not correlated with hematological values.
Impact DASH System on Patients' Dietary Pattern after Recovery from Myocardial Infarction
Authors: Hadi Sabri Sh. , Khudur Khalida M.
Published: October 2024

Background: One of the top three causes of death and morbidity is cardiovascular disease Myocardial infarction is a clinical illness defined by quickly growing severe myocardial ischemia. It is the most frequent health problem in the world and the main cause of mortality.
Objectives: The study aims to assess the dietary pattern of food intake frequency for patients with post- myocardial infarction.
Patients & Methods: The quasi-experimental design has been carried out to determine the impact of the Dietary Approaches to Stop Hypertension system on patients with post-myocardial infarction, in the Al-Diwaniyah Teaching Hospital's cardiac outpatient clinic for the period from 17th April 2023 to 3rd May, 2024. Nonprobability (purposive) sample of (60) patients were selected who recovering from myocardial infarction at AL Diwaniyah Teaching Hospital. The study instrument comprised of (3) parts: part I: demographic details of the patient, which included seven items. Part II: Data on clinical characteristics, consisting of (3) items and Part III: Evaluation of diet frequency consisting of (8) items.
Results: The study results showed that most of the food groups were (less than the Recommended Daily Servings) in pre-test, then became (Equal to the Recommended Daily Servings) in post-test in the study group. While most of the food groups were (Less than the Recommended Daily Servings) in pre-test and post-test in the control group. Also, there were statistically significant differences between the study and control groups in the post-test measurements regarding the evaluation of the dietary pattern of food intake frequency at (p. value <0.05).
Conclusions: The DASH system was effective in improving the dietary pattern of patients after recovery from myocardial infarction. And in assessing food intake frequency and the dietary pattern at p. value <0.05). There were statistically significant differences between the study and the control group on the post-test measures.
Imbalance of Pro and Anti-Inflammatory Cytokines in Rheumatoid Arthritis in Iraqi Patients
Authors: Salih Shakir M. , Adam Sevki A.
Published: October 2024

خلفية البحث: التهاب المفاصل الروماتويدي (RA) هو مرض التهابي مزمن مناعي ذاتي يصيب الجسم كله ويتميز بمشاكل غير مفصلي وغير مفصلي. في كثير من الحالات، يحدث المرض من خلال التفاعل بين الجينات والعوامل البيئية.
الاهداف: تم تصميم هذا البحث للتحقيق في تأثير عدم التوازن بين السيتوكينات المؤيدة والمضادة للالتهابات في المرضى الذين يعانون من التهاب المفاصل الروماتويدي ومقارنة نتائجهم مع الأشخاص الأصحاء الذين لا يعانون من المرض.
المرضى وطرق العمل/ المواد وطرق العمل: في هذه الدراسة تم اختيار مجموعتين لدراسة تأثير بعض التحاليل المخبرية مثل السيتوكينات المسببة للالتهاب الروماتويدي والسيتوكينات المضادة للروماتيزم للمرضى المترددين على المؤسسات الصحية في محافظة الأنبار / العراق للفترة من 2/1/2023 إلى 30/8/2023 والذين ظهرت عليهم أعراض التهاب المفاصل الروماتويدي مع مقارنة نتائج فحوصاتهم المختبرية مع نتائج الأشخاص الأصحاء للمقارنة.
النتائج: أشارت النتائج إلى أن مستوى السيتوكين IL1 ارتفع بشكل ملحوظ في مجموعة مرضى التهاب المفاصل الروماتويدي مقارنة بمجموعة الأشخاص الأصحاء. أظهرت النتائج أن متوسط مستوى السيتوكين IL6 للمجموعتين المدروستين يختلف اختلافا كبيرا في القيمة. أكدت نتائج قياس مستويات السيتوكين IL20 في مجموعتي الدراسة أن مستوى السيتوكين قد ارتفع بشكل ملحوظ في مجموعة مرضى التهاب المفاصل الروماتويدي مقارنة بمجموعة الأشخاص الأصحاء. أظهرت النتائج أن مستوى السيتوكين IL4 أظهر تفوقا كبيرا بين مرضى التهاب المفاصل الروماتويدي مقارنة بمجموعة الأشخاص الأصحاء.
الاستنتاجات: ارتفع مستوى السيتوكين IL1 و IL4 و IL6 و IL20 بشكل ملحوظ في مجموعة مرضى التهاب المفاصل الروماتويدي مقارنة بمجموعة الأشخاص الأصحاء.
МИРОВЫЕ ИННОВАЦИИ ЭКСТРАКТИВНОЙ МЕТАЛЛУРГИИ ТИТАНА
Authors: Ахметова К.Ш. , Кенжалиев Б.К. , Гладышев С.В. , Ахмадиева Н.К. , Имангалиева Л.М.
Published: October 2024

Представлен аналитический обзор мирового рынка и мировых ресурсов титана, методов переработки труднообогатимых весьма сложных по вещественному составу ильменитовых концентратов, достижений мировых производителей высокотехнологичной продукции титана. Освещены результаты деятельности австралийской компании Austpac Resources, создавшей лучшую, предпочтительно используемую, универсальную технологию производства высокочистого ситетического рутила из концентратов ильменитовых песков; канадской компании QIT-Fer & Titane Inc., разработавшей технологию производства сопоставимого по качеству с синтетическим рутилом модифицированного титанового шлака, выплавляемого из бедного по диоксиду титана гемоильменитового концентрата с высоким содержанием тесно ассоциированных жильных минералов вмещающей анортозитовой породы и вкраплениями изоморфных примесей множества сидерофильных микроэлементов; южноафриканской компании Richards Bay Minerals, поставляющей на рынок 85% титановый шлак и 94% синтетический рутил, получаемых переработкой высокохромистого мелкодисперного ильменита песчаных дюн адаптированной технологией канадской компании QIT; Усть-Каменогорского титаномагниевого комбината Казахстана обеспечивающего производство титана губчатого, титановых слитков и сплавов аэрокосмического назначения одностадийной восстановительной плавкой угольной шихты смеси низко- и высокосортного ильменитовых концентратов. Отражены успехи научных организаций в решении актуальных проблем, посвященных сокращению себестоимости производства титановых пигментов и металлического титана, расширению сырьевой базы ценного металла и улучшению экологии окружающей среды.
“ҚЫЗЫЛ МИЯ” ӨСІМДІГІНІҢ ТАМЫРЫНАН ГЛИЦИРРИЗИН ҚЫШҚЫЛЫН СИНТЕЗДЕУ ЖӘНЕ ХИМИЯЛЫҚ ҚАСИЕТТЕРІН ЗЕРТТЕУ
Authors: Имангалиева Б. , Досанова Б. , Торсыкбаева Б. , Нурлыбаев И. , Сұлтанов Н.
Published: October 2024

Мия өсімдігі Қазақстанда өсетін дәрілік өсімдіктердің негізгі түріне жатады. Бұлар-ботаникалық қасиеттерінің жіктелуіне байланысты бұршақ тұқымдасына жататын көпжылдық шөптесін өсімдіктер. Қазақстанның шөл,  шөлейтті, далалы аймақтарында өсетін бірнеше түрі бар. Қызыл мия тамыры медицинада қақырық түсіретін, іс жүргізетін, тыныс жолдар ауруын бәсеңдететін, суық тигенге қарсы дәрі ретінде пайдаланылады. Қызыл мия препараты суық тигенде, тыныс жолдарының қабынуына, аллергиялық  тері ауруларына ем. Глицирренат препараты трихомонат және гинекологиялық ауруларды, халкорин, асқазан және бауыр ауруларын емдеуге ұсынылған.
Мия өсімдігінің тамырында ең белсенді әрі активті биологиялық, фармакологиялық негізгі компонент «глицирризин қышқылы» болып есептеледі. Бұл қышқыл – пентациклді үштерпеноидты сапонин болып табылады және оның концентрациясы Қызыл мия өсімдігінің тамырымында 25%-ды құрайды, сондай-ақ тамырдың құрамында полифенолды қосылыстардың үлесі 3-5%-ға жуық болып келеді.
Глицирризин қышқылы мия өсімдігінің тамырында калий, кальций және магний тұздары ретінде кезедеседі. Таза глицирризин қышқылын синтездеу концентрлі күкірт қышқылы қатысында жүзеге асады. Ол туралы эксперименттік бөлімнің зертханалық жұмыстары жүргізілді.
Зерттелетін өнімге сандық талдау жасалды. Зерттеу барысында еріткіш ретінде су, аммиак алынды. Зерттеу нысаны мия өсімдігіне салыстырмалы талдау үшін географиялық орнына сәйкес Қызылорда облысы мен Батыс Алтай тауларының бөктерінде өсетін «Қызыл мия» өсімдігінің тамыры және Орал тауларының бөктерінде өсетін «Орал мия» өсімдігінің тамыры алынды. Талдау көрсеткіші ретінде масса анықталды. Мақалада глицирризин қышқылының сандық құрамын анықтау және экстракттың құрамындағы биологиялық белсенді заттардың сапалық қасиеттері салыстырамалы талданып, зерттеу жүргізу және нәтижелерін өңдеу баяндалған.
The existences and asymptotic behavior of solutions to stochastic semilinear generalized Rayleigh–Stokes equation with delays
Authors: Quan Nguyen Nhu
Published: October 2024

We consider a functional stochastic delay semilinear Rayleigh–Stokes equation involving Riemann–Liouville derivative. Our aim is using the resolvent theory, fixed point argument to prove the global solvability and gives some sufficient conditions to ensure the asymptotic stability of mild solutions in the mean square moment.
Kirchhoff problems with logarithmic double phase operator: Existence and multiplicity results
Authors: Vetro Francesca
Published: October 2024

In this paper, we focus on Kirchhoff type problems driven by a logarithmic double phase operator with variable exponents. Under very general assumptions on the nonlinearity and using variational tools, like the mountain pass theorem, we establish the existence of at least one nontrivial weak solution for the problem under consideration. Then, under different hypotheses on the reaction term, we are also able to derive a multiplicity result of solutions for our problem. We stress that in order to produce such a multiplicity result a key role is played by a variant of the symmetric mountain pass theorem.
Extract from Falcaria vulgaris loaded with exosomes for the treatment of hypertension in pregnant mice: In vitro and In vivo investigations
Authors: Chen Jing , Wang Huan , Zhu Jing
Published: October 2024

BACKGROUND: Hypertensive disorders during pregnancy pose significant risks to both maternal and fetal health, necessitating safe and effective therapeutic interventions. OBJECTIVE: This study aimed to investigate the potential of an extract derived from Falcaria vulgaris (FV), loaded with exosomes to form the Exo/FV complex, as a novel therapeutic agent for the management of hypertension in pregnant mice: antioxidants, antimicrobials, and phenolic compounds present in FV lower blood pressure. METHODS: The isolation of exosomes was done by ultracentrifugation methods and the FV was loaded into the exosomes by electroporation method. RESULTS: The Exo/FV was found to be spherical with diameter ranges from 20 to 30 nm and they were tested for biocompatibility in NHI 3T3 cell lines and found to be effective. This research investigated in vivo hypertension in mice induced by L-NAME and treated with FV and Exo/FV and found that AChE and MAO determine mice’s redox state tends to reduce blood pressure. Increased non-protein thiol (NP-SH) and decreased lipid peroxidation were also found, and PDE-5, ACE, Arginase, and MDA activity has also been tested. CONCLUSION: This analysis showed that Exo/FV effectively treated hypertension during pregnancy.
A study of the nonlinear behaviour of the irregular Beni Haroun cable-stayed bridge to progressive seismic failure under SVGM
Authors: Ouanani Mouloud , Sandjak Khaled , Tiliouine Boualem
Published: October 2024

The progressive failure of the nonlinear irregular Cable-Stayed Bridges (CSBs) under Spatial Variability of Ground Motions (SVGM) counting seismic wave propagation, incoherence effect and site-response effect is investigated. A spectral representation method is used in order to develop a computer code. This code is used to simulate SVGM time histories to be compatible with an overall coherency function and a target response spectrum, A three-dimensional Finite Element Model (FEM) of an asymmetric bridge: the Beni Haroun cable-stayed bridge (CSB) (North Eastern Algeria) is developed in order to include the effects of the main components of SVGM on response parameters in terms of variations of absolute maximum vertical displacements and flexural moments along the deck and on height of short and tall pylons of study CSB, in particular, nonlinear bridge response quantities are examined in terms of rotational ductility demands at the ends of the short and tall piers of the bridge under all components of SVGM. The numerical results are comforted with those obtained assuming uniform seismic excitations. The analysis results reveal, among others, that the bridge responses are very sensitive to the SVGM, with site-response effects being more critical for bridge response than those of incoherence components and wave propagation. As a general trend, it is showed that the assumption of uniform excitation results in much lower ductility demands on bridges than incoherence and site SVGM components and that the latter should be considered for the seismic response assessments and progressive seismic failure studies of irregular cable-stayed bridges.
Projecting the Likely Impact of COVID-19 Infections on the Prevalence of Dementia in the United States
Authors: Ansah John P. , Zacharia Hannah , Chiu Chi-Tsun
Published: October 2024

Background: The association between COVID-19 infection and the onset of dementia among adults 65 years and older has the potential to increase the burden of dementia worldwide significantly. Our research, which focuses on understanding the likely increase in the burden of dementia due to COVID-19 infection in the USA, has crucial public policy implications. By providing these insights, we aim to empower policymakers, healthcare professionals, researchers, and public health officials to make informed decisions and plan for the future. Objective: Project the prevalence of dementia in the United States while accounting for the impact of COVID-19 infection on the onset of dementia. Methods: A dynamic multi-state population model was developed. The model was initialized with USA demographic data and estimates of age, gender, and race-specific transition rates from the Health and Retirement Study (HRS). Results: The projected increase in the burden of dementia among Americans 65 years and older is a staggering 14.838 million by 2050. However, due to the COVID-19 pandemic, we anticipate an additional 265,000 to 677,000 older adults 65 years and older will be affected by dementia. This will escalate the burden of dementia to a potential 15.103 million to 15.515 million by 2050, a significant human toll that we must be prepared for. Conclusions: The projected dementia numbers underscore the urgent need for policy and intervention in social care services and healthcare needs planning. This includes providing robust support systems for caregivers and ensuring the healthcare staff is adequately trained to meet the healthcare needs of dementia patients and their families.