bluuebunny/crossref_metadata_2025 huggingface dataset:
A Brain-Inspired Theory of Mind Spiking Neural Network for Reducing Safety Risks of Other Agents
Authors: Zhao Zhuoya , Lu Enmeng , Zhao Feifei , Zeng Yi , Zhao Yuxuan
Published: April 2022

Artificial Intelligence (AI) systems are increasingly applied to complex tasks that involve interaction with multiple agents. Such interaction-based systems can lead to safety risks. Due to limited perception and prior knowledge, agents acting in the real world may unconsciously hold false beliefs and strategies about their environment, leading to safety risks in their future decisions. For humans, we can usually rely on the high-level theory of mind (ToM) capability to perceive the mental states of others, identify risk-inducing errors, and offer our timely help to keep others away from dangerous situations. Inspired by the biological information processing mechanism of ToM, we propose a brain-inspired theory of mind spiking neural network (ToM-SNN) model to enable agents to perceive such risk-inducing errors inside others' mental states and make decisions to help others when necessary. The ToM-SNN model incorporates the multiple brain areas coordination mechanisms and biologically realistic spiking neural networks (SNNs) trained with Reward-modulated Spike-Timing-Dependent Plasticity (R-STDP). To verify the effectiveness of the ToM-SNN model, we conducted various experiments in the gridworld environments with random agents' starting positions and random blocking walls. Experimental results demonstrate that the agent with the ToM-SNN model selects rescue behavior to help others avoid safety risks based on self-experience and prior knowledge. To the best of our knowledge, this study provides a new perspective to explore how agents help others avoid potential risks based on bio-inspired ToM mechanisms and may contribute more inspiration toward better research on safety risks.
Backpropagation With Sparsity Regularization for Spiking Neural Network Learning
Authors: Yan Yulong , Chu Haoming , Jin Yi , Huan Yuxiang , Zou Zhuo , Zheng Lirong
Published: April 2022

The spiking neural network (SNN) is a possible pathway for low-power and energy-efficient processing and computing exploiting spiking-driven and sparsity features of biological systems. This article proposes a sparsity-driven SNN learning algorithm, namely backpropagation with sparsity regularization (BPSR), aiming to achieve improved spiking and synaptic sparsity. Backpropagation incorporating spiking regularization is utilized to minimize the spiking firing rate with guaranteed accuracy. Backpropagation realizes the temporal information capture and extends to the spiking recurrent layer to support brain-like structure learning. The rewiring mechanism with synaptic regularization is suggested to further mitigate the redundancy of the network structure. Rewiring based on weight and gradient regulates the pruning and growth of synapses. Experimental results demonstrate that the network learned by BPSR has synaptic sparsity and is highly similar to the biological system. It not only balances the accuracy and firing rate, but also facilitates SNN learning by suppressing the information redundancy. We evaluate the proposed BPSR on the visual dataset MNIST, N-MNIST, and CIFAR10, and further test it on the sensor dataset MIT-BIH and gas sensor. Results bespeak that our algorithm achieves comparable or superior accuracy compared to related works, with sparse spikes and synapses.
Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation
Authors: Polymeris Alexandros A. , Helfenstein Fabrice , Benkert Pascal , Aeschbacher Stefanie , Leppert David , Coslovsky Michael , Willemse Eline , Schaedelin Sabine , Blum Manuel R. , Rodondi Nicolas , Reichlin Tobias , Moschovitis Giorgio , Wuerfel Jens , De Marchis Gian Marco , Engelter Stefan T. , Lyrer Philippe A. , Conen David , Kühne Michael , Osswald Stefan , Bonati Leo H. , Kuhle Jens ,   the Swiss-AF Investigators
Published: April 2022

Objective

Serum neurofilament light chain (sNfL) is increasingly used as a neuroaxonal injury biomarker in the elderly. Besides age, little is known about how other physiological factors like renal function and body mass index (BMI) alter its levels. Here, we investigated the association of estimated glomerular filtration rate (eGFR) and BMI with sNfL in a large sample of elderly patients with atrial fibrillation (AF).

Methods

This is a cross-sectional analysis from the Swiss-AF Cohort (NCT02105844). We measured sNfL using an ultrasensitive single-molecule array assay. We calculated eGFR using the chronic kidney disease epidemiology collaboration (CKD-EPI) creatinine (eGFRcrea) and creatinine–cystatin C (eGFRcrea–cys) formulas, and BMI from weight and height measurements. We evaluated the role of eGFR and BMI as determinants of sNfL levels using multivariable linear regression and the adjusted R2 (R2adj).

Results

Among 2,277 Swiss-AF participants (mean age 73.3 years), eGFRcrea showed an inverse curvilinear association with sNfL after adjustment for age and cardiovascular comorbidities. BMI also showed an independent, inverse linear association with sNfL. The R2adj of models with age, eGFRcrea, and BMI alone was 0.26, 0.35, and 0.02, respectively. A model with age and eGFRcrea combined explained 45% of the sNfL variance. Sensitivity analyses (i) further adjusting for vascular brain lesions (N = 1,402 participants with MRI) and (ii) using eGFRcrea–cys yielded consistent results.

Interpretation

In an elderly AF cohort, both renal function and BMI were associated with sNfL, but only renal function explained a substantial proportion of the sNfL variance. This should be taken into account when using sNfL in elderly patients or patients with cardiovascular disease.
Deficits in Sense of Body Ownership, Sensory Processing, and Temporal Perception in Schizophrenia Patients With/Without Auditory Verbal Hallucinations
Authors: He Jingqi , Ren Honghong , Li Jinguang , Dong Min , Dai Lulin , Li Zhijun , Miao Yating , Li Yunjin , Tan Peixuan , Gu Lin , Chen Xiaogang , Tang Jinsong
Published: April 2022

It has been claimed that individuals with schizophrenia have difficulty in self-recognition and, consequently, are unable to identify the sources of their sensory perceptions or thoughts, resulting in delusions, hallucinations, and unusual experiences of body ownership. The deficits also contribute to the enhanced rubber hand illusion (RHI; a body perception illusion, induced by synchronous visual and tactile stimulation). Evidence based on RHI paradigms is emerging that auditory information can make an impact on the sense of body ownership, which relies on the process of multisensory inputs and integration. Hence, we assumed that auditory verbal hallucinations (AVHs), as an abnormal auditory perception, could be linked with body ownership, and the RHI paradigm could be conducted in patients with AVHs to explore the underlying mechanisms. In this study, we investigated the performance of patients with/without AVHs in the RHI. We administered the RHI paradigm to 80 patients with schizophrenia (47 with AVHs and 33 without AVHs) and 36 healthy controls. We conducted the experiment under two conditions (synchronous and asynchronous) and evaluated the RHI effects by both objective and subjective measures. Both patient groups experienced the RHI more quickly and strongly than HCs. The RHI effects of patients with AVHs were significantly smaller than those of patients without AVHs. Another important finding was that patients with AVHs did not show a reduction in RHI under asynchronous conditions. These results emphasize the disturbances of the sense of body ownership in schizophrenia patients with/without AVHs and the associations with AVHs. Furthermore, it is suggested that patients with AVHs may have multisensory processing dysfunctions and internal timing deficits.
A Circadian Hygiene Education Initiative Covering the Pre-pandemic and Pandemic Period Resulted in Earlier Get-Up Times in Italian University Students: An Ecological Study
Authors: Montagnese Sara , Zarantonello Lisa , Formentin Chiara , Giusti Gianluca , Mangini Chiara , Isherwood Cheryl M. , Ferrari Paolo , Paoli Antonio , Mapelli Daniela , Rizzuto Rosario , Toppo Stefano , Skene Debra J. , Vettor Roberto , Costa Rodolfo
Published: April 2022

The aims of the present study were to obtain sleep quality and sleep timing information in a group of university students and to evaluate the effects of a circadian hygiene education initiative. All students of the University of Padova (approximately 64,000) were contacted by e-mail (major campaigns in October 2019 and October 2020) and directed to anad hocwebsite for collection of demographics and sleep quality/timing information. Participants (n= 5,740) received one of two sets of circadian hygiene advice (“A regular life” or “Bright days and dark nights”). Every month, they were then asked how easy it had been to comply and provided with the advice again. At any even month from joining, they completed the sleep quality/timing questionnaires again. Information on academic performance was obtainedpost hoc, together with representative samples of lecture (n= 5,972) and examination (n= 1,800) timings, plus lecture attendances (n= 25,302). Fifty-two percent of students had poor sleep quality, and 82% showed signs of social jetlag. Those who joined in October 2020, after several months of lockdown and distance learning, had better sleep quality, less social jetlag, and later sleep habits. Over approximately a year, the “Bright days and dark nights” advice resulted in significantly earlier get-up times compared with the “A regular life” advice. Similarly, it also resulted in a trend toward earlier midsleep (i.e., the midpoint, expressed as clock time, between sleep onset and sleep offset) and toward a decrease in the latency between wake-up and get-up time, with no impact on sleep duration. Significant changes in most sleep quality and sleep timing variables (i.e., fewer night awakenings, less social jetlag, and delayed sleep timing during lock-down) were observed in both advice groups over approximately a year, mostly in association with pandemic-related events characterizing 2020. Early chronotype students had better academic performances compared with their later chronotype counterparts. In a multivariate model, sleep quality, chronotype and study subject (science and technology, health and medical, or social and humanities) were independent predictors of academic performance. Taken together, these results underlie the importance of designing circadian-friendly university timetables.
What Are the Human-Specific Aspects of Neocortex Development?
Authors: Mora-Bermúdez Felipe , Huttner Wieland B.
Published: April 2022

When considering what makes us human, the development of the neocortex, the seat of our higher cognitive abilities, is of central importance. Throughout this complex developmental process, neocortical stem and progenitor cells (NSPCs) exert a priming role in determining neocortical tissue fate, through a series of cellular and molecular events. In this Perspective article, we address five questions of relevance for potentially human-specific aspects of NSPCs, (i) Are there human-specific NSPC subtypes? (ii) What is the functional significance of the known temporal differences in NSPC dynamics between human and other great apes? (iii) Are there functional interactions between the human-specific genes preferentially expressed in NSPCs? (iv) Do humans amplify certain metabolic pathways for NSPC proliferation? and finally (v) Have differences evolved during human evolution, notably between modern humans and Neandertals, that affect the performance of key genes operating in NSPCs? We discuss potential implications inherent to these questions, and suggest experimental approaches on how to answer them, hoping to provide incentives to further understand key issues of human cortical development.
Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium
Authors: Ran Wei , Liang Ning , Yuan Ruixue , Wang Zhiqiao , Gao Jin
Published: April 2022

Postoperative delirium (POD) is a common postoperative complication in elderly patients and seriously affects postoperative recovery. The exact mechanism of POD is still unclear. Therefore, it is necessary to explore the mechanism of POD in transcriptional regulation. At present, circRNAs have been proven to play an important role in a variety of mental health and cognitive disorders, such as Alzheimer’s disease, depression and schizophrenia. To reveal the effect of circRNA on POD, we used microarray to analyze the differential expression profiles of circRNAs in the hippocampus of 12-month-old mice between the tibial fracture and control groups. A total of 1,4236 circRNAs were identified. Compared with the control group, there were 500 circRNAs with increased expression and 187 with decreased expression. The accuracy of the microarray data was further verified by qRT–PCR. Finally, GO enrichment and KEGG pathway analyses indicated that changes in axon orientation, ubiquitin-mediated proteolysis, glutamate synapses, the estrogen signaling pathway, the RAS signaling pathway and other systems may be important potential pathological mechanisms in the progression of POD. In particular, we found that the HOMER1 gene and its transcript mmu_circRNA_26701 are specifically expressed in the glutamate synapse, which may provide new clues and intervention targets for the progression of this refractory disease.
Possible Roles of Specific Amino Acids in β-Tubulin Isotypes in the Growth and Maintenance of Neurons: Novel Insights From Cephalopod Mollusks
Authors: Ludueña Richard F.
Published: April 2022

Microtubules, are formed of the protein tubulin, which is a heterodimer of α- and β-tubulin subunits. Both α- and β-tubulin exist as numerous isotypes, differing in amino acid sequence and tissue distribution. Among the vertebrate β isotypes, βIII has a very narrow distribution, being found primarily in neurons and in advanced cancers. The places in the amino acid sequence where βIII differs from the other β isotypes are highly conserved in evolution. βIII appears to be highly resistant to reactive oxygen species and it forms highly dynamic microtubules. The first property would be very useful in neurons, which have high concentrations of free radicals, and the high dynamicity would aid neurite outgrowth. The same properties make βIII useful in cancers. Examination of the amino acid sequences indicates a cysteine cluster at positions 124–129 in βIII (CXXCXC). This occurs in all βIII isotypes but not in βI, βII, or βIV. βIII also lacks the easily oxidized C239. Both features could play roles in free radical resistance. Many aggressive tumors over-express βIII. However, a recent study of breast cancer patients showed that many of them mutated their βI, βII, and βIV at particular places to change the residues to those found at the corresponding sites in βIII; these are all sites that are highly conserved in vertebrate βIII. It is possible that these residues are important, not only in the resistance to free radicals, but also in the high dynamicity of βIII. The cephalopod mollusks are well known to be highly intelligent and can remodel their own brains. Interestingly, several cephalopods contain the cysteine cluster as well as up to 7 of the 17 residues that are highly conserved in vertebrate βIII, but are not found in βI, βII, or βIV. In short, it is possible that we are looking at a case of convergent evolution, that a βIII-like isotype may be required for neuronal growth and function and that a structure-function study of the particular residues conserved between vertebrate βIII and cephalopod tubulin isotypes could greatly increase our understanding of the role of the various tubulin isotypes in neuronal growth and function and could aid in the development of novel anti-tumor drugs.
Effect of Salt (Sodium Chloride) Replacement With Potassium Chloride, High Pressure Processing, and Cold Storage at 4°C on Beef Sausage Volatile Compounds
Authors: Ojangba Theodora , Zhang Li , Boamah Solomon , Gao Yanlei , Wang Zhuo , Alhassan Martha Wunnam
Published: April 2022

This study aimed to investigate the partial substitution of 0, 25 and 50% sodium chloride (NaCl) by potassium chloride (KCl) coupled with high-pressure processing (HPP) effects on volatile compounds and lipid oxidation of beef sausage at five (0, 3, 7, 14, and 21) different cold storage days (4°C). The odor activity values (OAV) of the various compounds were visualized by heat map analysis. Thiobarbituric acid reactive substances (TBARS) of the samples treated with 100% NaCl and HPP increased by an average of 0.52 ± 0.01 mg MDA/kg compared with the control (100% NaCl-no HPP) across the 21 storage days. In addition, 50% NaCl substitution with KCl in combinations with HPP treatments increased TBARS across the 21 storage days by an average of 0.40 ± 0.02 mg MDA/kg compared with no HPP treatment. However, on day 3, there was a sharp decrease in TBARS by an average of 0.10 ± 0.01 mg MDA/kg compared with days 0, 7, 14, and 21 in all treatments. At the end of 21 days of storage, a total of 227 volatile compounds were identified and quantified in the beef sausage, including 43 aldehydes, 46 phenols, 8 ketones, 30 alcohols, 14 acids, 12 esters, 27 terpenes, and 47 alkanes. However, no ketone compounds were detected on days 7, 14 and 21; esters on day 14 and acids on days 14 and 21 in the samples treated with or without HPP across the salts levels. However, high OAVs (OAV > 1) were obtained after partial substitution of NaCl with KCl at 25 and 50% with HPP treatment compared to the samples not treated with HPP. The aroma perceived in the beef sausage was due to compounds with the highest OAVs such as; pentadecanal, benzyl carbazate, anethole, myristicin, o-cresol, phenylacetaldehyde and (E)-methyl isoeugenol, pentadecanal, hexanoic acid, octanoic acid, eugenol, trans-2-nonenal, trans-2-octenal, trans-2-decenal, 2-butyl-1-octanol, 2,3-butanedione, ethyl hexanoate, ethyl octanoate, (-)-4-terpineol which had an OAV > 1 as compared to the other compounds with an OAV < 1. In conclusion, 25 and 50% NaCl partial replacement with KCl coupled with HPP technique can be considered in producing low-NaCl beef sausage in order to improve the flavor and decrease lipid oxidation during cold storage.
Discussion on the Treatment Strategy for Stage ⅡA1 Cervical Cancer (FIGO 2018)
Authors: Chen Xiaolin , Liang Wentong , Duan Hui , Wu Minling , Zhan Xuemei , Dai Encheng , Lv Qiubo , Xie Qinghuang , Liu Ruilei , Xu Yan , Bin Xiaonong , Lang Jinghe , Liu Ping , Chen Chunlin
Published: April 2022

Objective

This study aimed to explore the best treatment strategy for International Federation of Gynecology and Obstetrics (FIGO) 2018 stage IIA1 cervical cancer patients by comparing the survival outcomes of two treatment methods: abdominal radical hysterectomy (ARH) with standard postoperative therapy and radio-chemotherapy (R-CT).

Methods

Patients with FIGO2018 stage IIA1 cervical cancer who underwent ARH or received R-CT were screened from the clinical diagnosis and treatment for cervical cancer in China (Four C) database. The recurrence cases between the two groups were analyzed. The 5-year overall survival (OS) and disease-free survival (DFS) of patients diagnosed with stage IIA1 cervical cancer in 47 hospitals in mainland China between 2004 and 2018 were compared by using propensity score matching (PSM).

Results

A total of 724 patients met the inclusion criteria. In the total study population, The R-CT group had higher recurrence (22.8% for the R-CT group and 11.2% for the ARH group, P<0.001) rates compared to the ARH group.The 5-year OS and DFS of the ARH group (n=658) were significantly higher than those of the R-CT group (n=66) (OS: 85.9% vs. 71.2%, P=0.009; DFS: 79.2%vs. 70.5%, P=0.027). R-CT was associated with worse 5-year OS (HR=3.19, 95% CI: 1.592-6.956, P=0.001) and DFS (HR=2.089, 95% CI: 1.194-3.656, P=0.01). After 1:2 PSM, the 5-year OS and DFS of the ARH group (n=126) were significantly higher than those of the R-CT group (n=64) (OS:88.9% vs. 70.1%, P=0.04; DFS:82.8% vs. 69.8%, P=0.019). R-CT was still associated with worse 5-year OS (HR=2.391, 95% CI: 1.051-5.633, P=0.046) and DFS (HR=2.6, 95% CI: 1.25-5.409, P=0.011).

Conclusion

Our study demonstrated that for stage FIGO2018 stage IIA1 cervical cancer patients, ARH offers better oncological outcomes than R-CT.
Targeting TNFR2: A Novel Breakthrough in the Treatment of Cancer
Authors: Li Muchun , Zhang Xiaozhen , Bai Xueli , Liang Tingbo
Published: April 2022

Tumor necrosis factor (TNF) receptor type II (TNFR2) is expressed in various tumor cells and some immune cells, such as regulatory T cells and myeloid-derived suppressing cells. TNFR2 contributes a lot to the tumor microenvironment. For example, it directly promotes the occurrence and growth of some tumor cells, activates immunosuppressive cells, and supports immune escape. Existing studies have proved the importance of TNFR2 in cancer treatment. Here, we reviewed the activation mechanism of TNFR2 and its role in signal transduction in the tumor microenvironment. We summarized the expression and function of TNFR2 within different immune cells and the potential opportunities and challenges of targeting TNFR2 in immunotherapy. Finally, the advantages and limitations of TNFR2 to treat tumor-related diseases are discussed, and the problems that may be encountered in the clinical development and application of targeted anti-TNFR2 agonists and inhibitors are analyzed.
Survival Outcomes and Pattern of Relapse After SABR for Oligometastatic Prostate Cancer
Authors: Mercier Carole , Claessens Marc , De Troyer Bart , Debacker Tibaut , Fransis Karen , Vandeursen Hendrik , Ost Piet , Dirix Piet
Published: April 2022

Introduction

The addition of stereotactic ablative radiotherapy (SABR) to standard of care for patients with oligometastatic prostate cancer has the potential of improving survival and delaying further metastases. The primary aim of this analysis is to report survival outcomes and pattern of recurrence of patients with hormone-sensitive (HSPC) and castrate-resistant (CRPC) oligometastatic prostate cancer treated with SABR.

Methods

This is a single-center retrospective study of patients with oligometastatic prostate cancer treated in Iridium Network between 2014 and 2018. All patients with oligometastatic (≤3 active lesions) HSPC and CRPC treated with SABR were included. Data were collected using electronic records. Patterns of first progression following SABR were reported. Kaplan-Meier methods were used to determine survival outcomes.

Results

Eighty-seven men received SABR to 115 metastases. Nineteen patients were castrate-resistant and 68 hormone-sensitive at the time of SABR. Median follow-up was 41.6 months. In 25% of patients, no decline from baseline PSA was recorded. Median bPFS was 11.7 months (95% CI 7.6 - 18.3) for HSPC as well as CRPC (95% CI 6.4 - 24.0) (p=0.27). Median DMFS was 21.8 (95% CI 16.9 - 43.2) versus 17.6 months (95% CI 6.7 - 26.2) for HSPC versus CRPC, respectively (p=0.018). Median OS was 72.6 months (95% CI 72.6 – not reached) for HSPC and not reached for CRPC (95% CI 35.4 months – not reached) (p=0.026). For the subgroup of oligorecurrent HSPC, short-term androgen-deprivation therapy was associated with improved bPFS (median 6.0 vs. 18.3 months, HR 0.31, p<0.001) and DMFS (median 15.8 vs 29.6 months, HR 0.5, p=0.06). Information on pattern of relapse was retrieved for 79 patients: 45% (36/79) of these patients were long-term disease-free (>18 months), 28% (22/79) of patients wmere oligoprogressive (≤3 new lesions) and 27% (21/79) developed a polymetastatic relapse.

Conclusion

In this cohort, oligometastatic HSPC showed potential benefit from SABR with a median DMFS of 21.8 months. Well-selected patients with oligometastatic CRPC may also benefit from SABR. For patients with metachronous and repeat oligorecurrent HSPC, combining SABR with short-term androgen-deprivation therapy was associated with improved bPFS and DMFS. Overall, 36/87 (41%) of patients were still free from clinical relapse at 18 months.
Factors Associated With Hospitalization or Intensive Care Admission in Children With COVID-19 in Latin America
Authors: López-Medina Eduardo , Camacho-Moreno German , Brizuela Martin E. , Dávalos Diana M. , Torres Juan Pablo , Ulloa-Gutierrez Rolando , López Pio , Debbag Roberto , Pérez Paola , Patiño Jaime , Norero Ximena , Mariño Cristina , Luengas Miguel A. , Ensinck Gabriela , Daza Carlos , Luciani Kathia , Quintana Kuhner Paola , Rodriguez Mónica , Rodríguez-Auad Juan Pablo , Estrada-Villarroel Alejandra , Carnevale Mayli , Mantese Orlando Cesar , Berezin Eitan N. , Castillo José Iván , Mascareñas Abiel , Jimenez-Zambrano Andrea , Dueñas Lourdes , Melgar Mario , Galvez Nancy , Cantor Erika , Asturias Edwin J.
Published: April 2022

Background

Limited data is available from low-middle and upper-middle income countries of the factors associated with hospitalization or admission to pediatric intensive care unit (PICU) for children with COVID-19.

Objective

To describe the factors associated with hospitalization or PICU admission of children with COVID-19 in Latin America.

Method

Multicenter, analytical, retrospective study of children reported from 10 different Latin American countries to the Latin-American Society of Pediatric Infectious Diseases (SLIPE-COVID) research network from June 1, 2020, and February 28, 2021. Outpatient or hospitalized children <18 years of age with COVID-19 confirmed by polymerase chain reaction or antigen detection from the nasopharynx were included. Children with multisystem inflammatory syndrome in children (MIS-C) were excluded. Associations were assessed using univariate and multivariable logistic regression models.

Results

A total of 1063 children with COVID-19 were included; 500 (47%) hospitalized, with 419 (84%) to the pediatric wards and 81 (16%) to the ICU. In multivariable analyses, age <1 year (Odds Ratio [OR] 1.78; 95% CI 1.08–2.94), native race (OR 5.40; 95% CI 2.13–13.69) and having a co-morbid condition (OR 5.3; 95% CI 3.10–9.15), were associated with hospitalization. Children with metabolic or endocrine disorders (OR 4.22; 95% CI 1.76–10.11), immune deficiency (1.91; 95% CI 1.05–3.49), preterm birth (OR 2.52; 95% CI 1.41–4.49), anemia at presentation (OR 2.34; 95% CI 1.28–4.27), radiological peribronchial wall thickening (OR 2.59; 95% CI 1.15–5.84) and hypoxia, altered mental status, seizures, or shock were more likely to require PICU admission. The presence of pharyngitis (OR 0.34; 95% CI 0.25–0.48); myalgia (OR 0.47; 95% CI 0.28–0.79) or diarrhea (OR 0.38; 95% CI 0.21–0.67) were inversely associated with hospital admission.

Conclusions

In this data analysis reported to the SLIPE research network in Latin America, infants, social inequalities, comorbidities, anemia, bronchial wall thickening and specific clinical findings on presentation were associated with higher rates of hospitalization or PICU admission. This evidence provides data for prioritization prevention and treatment strategies for children suffering from COVID-19.
Multimodal Benefits of Exercise in Patients With Multiple Sclerosis and COVID-19
Authors: Razi Omid , Tartibian Bakhtyar , Laher Ismail , Govindasamy Karuppasamy , Zamani Nastaran , Rocha-Rodrigues Silvia , Suzuki Katsuhiko , Zouhal Hassane
Published: April 2022

Multiple sclerosis (MS) is a demyelinating disease characterized by plaque formation and neuroinflammation. The plaques can present in various locations, causing a variety of clinical symptoms in patients with MS. Coronavirus disease-2019 (COVID-19) is also associated with systemic inflammation and a cytokine storm which can cause plaque formation in several areas of the brain. These concurring events could exacerbate the disease burden of MS. We review the neuro-invasive properties of SARS-CoV-2 and the possible pathways for the entry of the virus into the central nervous system (CNS). Complications due to this viral infection are similar to those occurring in patients with MS. Conditions related to MS which make patients more susceptible to viral infection include inflammatory status, blood-brain barrier (BBB) permeability, function of CNS cells, and plaque formation. There are also psychoneurological and mood disorders associated with both MS and COVID-19 infections. Finally, we discuss the effects of exercise on peripheral and central inflammation, BBB integrity, glia and neural cells, and remyelination. We conclude that moderate exercise training prior or after infection with SARS-CoV-2 can produce health benefits in patients with MS patients, including reduced mortality and improved physical and mental health of patients with MS.
The Effect of Blood Flow-Restricted Low Resistance Training on Microvascular Circulation of Myocardium in Spontaneously Hypertensive Rats
Authors: Tan Zhaowen , Zhao Yan , Zheng Yuchan , Pan Ying
Published: April 2022

Objective: The purpose of this study was to explore the effect of blood flow-restricted low resistance training on microvascular rarefaction in the myocardium of spontaneously hypertensive rats (SHRs).

Methods: Four-week-old male SHRs were randomly divided into the following groups: Wistar-Kyoto (WKY), SHR control (SHR-SED), high-intensity resistance training (HIRT), low-intensity resistance training (LIRT), and blood flow-restricted low resistance training (BFRT). The exercise groups began to receive exercise intervention for 8 weeks at the age of 7 weeks. Blood pressure (BP), heart rate (HR), cardiac function, capillary density, and Vascular endothelial growth factor -Phosphatidylinositol 3-kinase-Protein kinase B-Endothelial nitric oxide synthetase (VEGF-Pi3k-Akt-eNOS) were assessed.

Results: 1) BP and HR of BFRT decreased significantly, Ejection fraction (EF) and Fraction shortening (FS) increased, and the effect of BFRT on lowering BP and HR was better than that of other groups (p < 0.05); 2) The expression of VEGF, VEGFR2, p-VEGFR2, Pi3k, Akt, p-Akt, eNOS and p-eNOS in the myocardium of the BFRT was significantly upregulated, and eNOS expression was significantly higher than other groups (p < 0 05); 3) the expression of VEGF in the blood of the BFRT was significantly upregulated, higher than SHR-SED, lower than HIRT (p < 0.05), and there was no significant difference between BFRT and LIRT(p > 0.05); 4) the capillary density in the myocardium of BFRT was significantly higher than other exercise groups (p < 0 05).

Conclusion: Blood flow-restricted low resistance training can activate the VEGF-Pi3k-Akt-eNOS pathway, upregulate the expression of VEGF in blood, improve microvascular rarefaction, and promote myocardial microvascular circulation, thereby improving cardiac function and lowering blood pressure, achieving the preventive effect of early hypertension.
Dopamine Modulation of Drosophila Ellipsoid Body Neurons, a Nod to the Mammalian Basal Ganglia
Authors: Frighetto Giovanni , Zordan Mauro A. , Castiello Umberto , Megighian Aram , Martin Jean-René
Published: April 2022

The central complex (CX) is a neural structure located on the midline of the insect brain that has been widely studied in the last few years. Its role in navigation and goal-oriented behaviors resembles those played by the basal ganglia in mammals. However, the neural mechanisms and the neurotransmitters involved in these processes remain unclear. Here, we exploited an in vivo bioluminescence Ca2+ imaging technique to record the activity in targeted neurons of the ellipsoid body (EB). We used different drugs to evoke excitatory Ca2+-responses, depending on the putative neurotransmitter released by their presynaptic inputs, while concomitant dopamine administration was employed to modulate those excitations. By using a genetic approach to knockdown the dopamine 1-like receptors, we showed that different dopamine modulatory effects are likely due to specific receptors expressed by the targeted population of neurons. Altogether, these results provide new data concerning how dopamine modulates and shapes the response of the ellipsoid body neurons. Moreover, they provide important insights regarding the similitude with mammals as far as the role played by dopamine in increasing and stabilizing the response of goal-related information.
Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo
Authors: Alser Maha , Salman Huseyin Enes , Naïja Azza , Seers Thomas Daniel , Khan Talha , Yalcin Huseyin Cagatay
Published: April 2022

Collectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart‘s pumping power, ventricles are particularly affected by developmental abnormalities, such as flow disturbances or genomic defects. Hypoplastic Right Heart Syndrome (HRHS) is a rare disease where the right ventricle is underdeveloped. In this study, we introduce a surgical procedure performed on chick embryo, termed right atrial ligation (RAL) for disturbing hemodynamics within the right heart aiming in order to generate an animal model of HRHS. RAL is a new surgical manipulation, similar to the well-studied left atrial ligation (LAL) surgery but it induces the hemodynamic change into the right side of the heart. After inducing RAL, We utilized techniques such as Doppler ultrasound, x-ray micro-CT, histology, and computational fluid dynamics (CFD) analysis, for a comprehensive functional and structural analysis of a developing heart. Our results displayed that RAL does not induce severe flow disturbance and ventricular abnormalities consistent with clinical findings. This study allows us to better understand the hemodynamics-driven CHD development and sensitivities of ventricles under disturbed flows.
Concurrent Improvement in Maize Grain Yield and Nitrogen Use Efficiency by Enhancing Inherent Soil Productivity
Authors: Zhigang Wang  , Bao-Luo Ma  , Yajian Li  , Rongfa Li  , Qi Jia  , Xiaofang Yu  , Jiying Sun  , Shuping Hu  , Julin Gao
Published: April 2022

Quantifying the relationships of maize yield and nitrogen use efficiency (NUE) to inherent soil productivity (ISP) could provide a theoretical basis for implementing strategies that concurrently narrow the yield gap, increase NUE, and improve soil quality. A field study under irrigation conditions was conducted at five locations with large differences in ISP (estimated by maize grain yield without using fertilizers) across various ecological regions in Inner Mongolia, China. Our results showed that the changes in maize yield and nitrogen partial factor productivity (PFPN) to ISP followed a linear-plateau model, with a common inflection point. When ISP was below 8.0 t ha–1, maize yield and PFPN were stagnating at a low level, due to a trade-off between the contribution of soil and chemical fertilizers to yield. When ISP exceeded 8.0 t ha–1, the contribution rate of soil to yield stabilized at 80%, resulting in a simultaneous increase in maize yield by 1.2 t ha–1 and PFPN by 4.6 kg kg–1, for increasing ISP at each t ha–1. Our results indicated that while keeping other management strategies unchanged, to increase maize yield and PFPN by 15% or further 30%, it is necessary to increase ISP to 9.3 and 10.4 t ha–1, respectively. In this scenario, N input will be reduced by 33.5 and 47.5%, and apparent N losses will be reduced by 11.7 and 21.5%, respectively. Therefore, enhancing ISP could lead to a simultaneous improvement in yield and NUE as well as strongly support the green development of maize production.
How Do Determiners of Job Performance Matter During COVID-19? The Conservation of Resource Theory
Authors: Zhao Wen-Xuan , Shao Lijin , Zhan Mingjun , Peng Michael Yao-Ping
Published: April 2022

During the COVID-19 pandemic, business managers are facing many challenges from a severe challenge. Many organizations have changed their original management mode and organizational behavior to improve employees’ organizational citizenship behavior, thus reducing their sense of anxiety and incapability. Thereinto, job performance of the employees also affects the growth and development of the organization. To explore how to fragment employees’ positive psychology and job performance, this study discusses the influence on employees’ subjective wellbeing and job performance from relevant factors at the organizational and individual levels. Also, to explore the influence of organizational support and occupation self-efficacy on job performance and the mediating role of subjective wellbeing during COVID-19, a total of 618 valid questionnaires were collected from all walks of life in 2020. Hypotheses were tested by structural equation modeling and Bootstrap technology. The results show that: (1) Professional self-efficacy and subjective wellbeing have a significant positive impact on job performance; (2) Subjective wellbeing plays a complete mediating role between organizational support and job performance, and subjective wellbeing plays a partial mediating role between professional self-efficacy and job performance; (3) Compared with the sense of organizational support, the positive effect of self-efficacy on job performance is more significant.
Perfectionistic Concerns and Mobile Phone Addiction of Chinese College Students: The Moderated Mediation of Academic Procrastination and Causality Orientations
Authors: Liu Guirong , Teng Xiuqin , Fu Yao , Lian Qiang
Published: April 2022

This study aimed to investigate the effect of perfectionistic concerns (PC) on mobile phone addiction (MPA) and the mediating role of academic procrastination (AP), as well as the moderating role of causality orientations (autonomous/controlled/impersonal orientation). A cross-sectional sample of 625 Chinese college students (20.8% male, mean age = 20.47 years old) completed measures of PC, AP, causality orientations, and MPA. We analyzed the survey data using structural equation modeling (SEM) in Mplus 8.0. PC was positively related to MPA. In addition, AP partially mediated this association. The hypothesized moderating effect of autonomous orientation and controlled orientation was not supported. Impersonal orientation moderated the second stage of the mediating effect of AP on the PC–MPA link in that the mediating effect was positive when impersonal orientation was high, while the mediating effect was not significant when impersonal orientation was low. The findings confirm the importance of investigating how individual difference (i.e., PC) contributes to MPA. The implications of the findings for relieving MPA or preventing college students from developing MPA are also discussed deeply and thoroughly.
The Psychology of Coronavirus Behavioral Health Mindset, Vaccination Receptivity, Customer Orientation and Community Public Service
Authors: Cunningham Michael R. , Druen Perri B. , Logsdon M. Cynthia , Dreschler Brian W. , Barbee Anita P. , Carrico Ruth L. , Billings Steven W. , Jones John W.
Published: April 2022

Three studies were conducted to explore the psychological determinants of COVID-deterrent behaviors. In Study 1, using data collected and analyzed both before and after the release of COVID-19 vaccines, mask-wearing, other preventative behaviors like social distancing, and vaccination intentions were positively related to assessments of the Coronavirus Behavioral Health Mindset (CVBHM); belief in the credibility of science; progressive political orientation; less use of repressive and more use of sensitization coping; and the attribution of COVID-19 safety to effort rather than ability, powerful forces, fate, or luck. In Study 2, favorable COVID-19 vaccination intentions were related to greater willingness to work, lower emotional distress, and greater customer experience mindset. Study 3 examined the personality and motives of individuals who volunteered to help deliver COVID-19 inoculations to the local community. The vaccine-giving volunteers, especially those with prosocial motives, had high CVBHM scores, belief in the credibility of science, low use of repressive coping, greater attribution of COVID-19 protection to effort, low likelihood of voting conservative, were older, and had more education than others. The majority of public health volunteers expressed prosocial motives to help people or join a cause (60.7%), but many (39.3%) expressed the personal motives of getting the COVID-19 vaccination for themselves, conveying a public image of compassion, or structuring time. Based on the three research studies, a COVID-19 Mindset Hierarchy model is proposed to integrate the results.
Sport Community Involvement and Life Satisfaction During COVID-19: A Moderated Mediation of Psychological Capital by Distress and Generation Z
Authors: Park Juho , Uhm Jun-Phil , Kim Sanghoon , Kim Minjung , Sato Shintaro , Lee Hyun-Woo
Published: April 2022

How can sport community involvement influence life satisfaction during a pandemic? Self-expansion theory posits that individuals seek to gain resources such as positive interpersonal relationships for growth and achievement. By considering psychological capital (PsyCap) as a dispositional resource intervening between sport community involvement and life satisfaction, we examined an empirical model to test the chain of effects. Based on the stress process model, distress and generational group (Generation Z vs. others) were tested as moderators. Participants (N = 233) responded to the scale item questionnaire for model assessment. Supporting the hypothesized relationships, the model was supported with a significant moderated-moderated mediation. The mediation effect of PsyCap was stronger when distress level was lower and such interaction effect was amplified for Generation Z (Gen Z). Whereas the global sport communities and Gen Z were found to be more particularly vulnerable to COVID-19, our findings suggest that there are psychological pathways for fans to maintain their resilience. It is foremost imperative to lower the stress level of sport fans for their community involvement to positively affect life satisfaction. Gen Z were more stressed during the pandemic but individuals who managed to cope with stress were able to leverage community involvement to boost positive psychological resources. Acknowledgment of these effects brings implications for better management strategies and provides avenues for new research.
Validation of Cyber Test for Future Soldiers: A Test Battery for the Selection of Cyber Soldiers
Authors: Lif Patrik , Sommestad Teodor , Albinsson Pär-Anders , Valassi Christian , Eidenskog Daniel
Published: April 2022

To facilitate recruitment of conscript cyber soldiers in Sweden, the Cyber Test for Future Soldiers (CTFS) was developed as a complement to the existing generic enrolment test (I-prov 2000). Consisting of several parts, CTFS measures different aspects of computer-related knowledge and cognitive abilities that we believe are of particular relevance to cyber security. This article describes the evaluation regarding CTFS’s validity and reliability based on data from 62 conscripts that took the test and the 27 selected conscripts finishing the training 1 year later (being the first to do so). Reliability was predicted through internal consistency and test–retest measures. Cronbach’s alpha for CTFS ranges from 0.79 to 0.86 whereas the test–retest reliability is 0.60. Evidence regarding validity was collected based on test content and internal structure. Convergent, discriminant, and predictive evidence are also presented. Perhaps most importantly, CTFS could predict the cyber soldiers’ performance during their training and added incremental validity to I-prov 2000. When adjusted for range restriction, I-prov 2000 predicted 20% of the variation in course score, while 34% of the variance was explained when CTFS was used in conjunction with I-prov 2000. The results show that CTFS already in its first version is adding value for the Swedish Armed Forces.
An Evaluation of the Acceptability, Appropriateness, and Utility of a Bibliotherapy for Children of Parents With a Mental Illness
Authors: Vetri Kelly , Piché Geneviève , Villatte Aude
Published: April 2022

Background

Children of parents with a mental illness are at higher risk for various psychiatric problems and adaptive difficulties compared to those of parents without mental health problems. Certain preventive psychoeducational interventions target these children to promote their well-being and resilience and prevent the emergence of adaptive difficulties. However, few such interventions have been developed and evaluated specifically for elementary school-aged children of parents with a mental illness.

Objectives

This study aims to evaluate an interpersonal psychotherapy-based book targeting children living with a parent with a mental illness.

Methods

The study examines children, parents and psychosocial workers' perception of the acceptability, appropriateness and utility of the book. In total, 22 participants answered online open-ended questions after reading the book.

Results

The book was highly appreciated and positively perceived by the families and psychosocial workers. Results suggest that children, parents and psychosocial workers viewed it as an appropriate and useful tool for supporting children with a parent with a mental illness. The present study reveals that the bibliotherapy appears well adapted to the developmental level of school-age children.

Discussion

This study presents a book that shows promise for supporting the resilience of elementary school-aged children having a parent with a mental illness. Results highlight the importance of tailoring the content and modalities of interventions to the developmental level, needs and preferences of elementary school-aged children. The relevance of a collaborative method is also discussed, thus providing knowledge regarding this type of approach for the development of interventions targeting children.