bluuebunny/crossref_metadata_2025 huggingface dataset:
T Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal
Authors: Admin Ada , James Eddie A. , Mallone Roberto , Kent Sally C. , DiLorenzo Teresa P.
Published: June 2020

The autoimmune
disease type 1 diabetes is characterized by effector T cell responses to
pancreatic beta cell-derived peptides presented by HLA class I and class II molecules, leading ultimately to
beta cell demise and insulin insufficiency.
Although a given HLA molecule presents a vast array of peptides, only
those recognized by T cells are designated as epitopes. Given their intimate link to etiology,
the discovery and
characterization of T cell epitopes is a critical aspect of type 1
diabetes research. Understanding epitope
recognition is also crucial for the pursuit of antigen-specific immunotherapies
and implementation of strategies for T cell monitoring. For these reasons, a cataloging and appraisal
of the T cell epitopes targeted in type 1 diabetes was completed over a decade
ago, providing an important resource for both the research and the clinical
communities. Here we present a
much-needed update and reappraisal of this earlier work, and include an online
appendix that cross-indexes each epitope with its primary references and Immune
Epitope Database (IEDB) identifier. Our
analysis includes a grading
scale to score the degree of evidence available for each epitope, which conveys our perspective on
several useful criteria for epitope evaluation. While providing an efficient summary
of the arguably impressive
current state of knowledge, this work also brings to light several
deficiencies. These include the need for
improved epitope validation, as few epitopes score highly by the criteria
employed, and the dearth of investigations of the epitopes recognized in the
context of several under-studied type 1 diabetes-associated HLA molecules.
Predicting 5- and 10-Year Mortality Risk in Older Adults with Diabetes Mellitus
Authors: Griffith Kevin N. , Prentice Julia C. , Mohr David C. , Conlin Paul R.
Published: June 2020

OBJECTIVE:
Several
diabetes clinical practice guidelines suggest that treatment goals may be
modified in older adults based on comorbidities, complications and life
expectancy. The long-term benefits of treatment
intensification may not outweigh short-term risks for patients with limited
life expectancy. Due to the uncertainty of determining life expectancy for
individual patients, we sought to develop and validate prognostic indices for
mortality in older adults with diabetes.

RESEARCH
DESIGN AND METHODS: We used a prevalence sample of Veterans
with diabetes who were aged ≥65 years on January 1, 2006 (n=275,190). Administrative data were queried for
potential predictors that included patient demographics, comorbidities and
procedure codes, lab values and anthropomorphic measurements, medication
history, and previous health services utilization. Logistic least absolute shrinkage and
selection operator (LASSO) regressions were employed to identify variables
independently associated with mortality. The resulting odds ratios were then
weighted to create prognostic indices of mortality over 5 and 10 years.

RESULTS:
Thirty-three
predictors of mortality were identified: four demographic variables,
prescriptions for insulin or sulfonylureas, five biomarkers, previous
outpatient and inpatient utilization, and twenty comorbidities/procedures. The
prognostic indices showed good discrimination, with c-statistics of 0.74 and
0.76 for 5 and 10-year mortality, respectively. The indices also demonstrated
excellent agreement between observed outcome and predictions, with calibration
slopes of 1.01 for both 5 and 10-year mortality.

CONCLUSIONS:
Prognostic
indices obtained from administrative data can predict 5- and 10-year mortality
in older adults with diabetes. Such a tool may enable clinicians and patients
to develop individualized treatment goals that balance risks and benefits of
treatment intensification.
OPPORTUNITIES FOR PROFESSIONAL COMPETENCE FORMATION WHEN STUDYING THE DISCIPLINE «BANKING»
Authors: Петрова Татьяна Адольфовна
Published: June 2020

Формирование экономических компетенций является важнейшим фактором в рамках образовательного процесса по специальности «Экономика» профиль «Финансы и кредит». Рассмотрены проблемы формирования компетенции по сбору и анализу исходных данных, необходимых для расчета экономических и социально-экономических показателей, которая связана с отсутствием корреляции между теоретическим и практическими блоками, а также действием социальных стереотипов в обществе, обусловливающих отношение к экономике как науке, которая развивается в другой плоскости, отличной от реальной жизни. Считаем необходимым при формировании означенной компетенции в образовательном процессе использовать системный подход, основанный на поступательном формировании знаний, позволяющих развить умения и сформировать навыки, доведенные до автоматизма. Приведенные примеры заданий реально используются в рамках преподавания дисциплины «Банковское дело» в целях формирования экономических компетенций. В рекомендациях по организации образовательного процесса упор сделан на постоянную актуализацию информации, экономических показателей, так как именно при обучении по экономическим специальностям актуальность сведений позволяет достаточно часто коррелировать свои выводы по ситуации в стране, экономической и банковской сферах.

Formation of economic competencies is the most important factor in the educational process in the specialty of “Economics”, profile “Finance and Credit”. The article discusses the problems of building competence in the collection and analysis of baseline data necessary for calculating economic and socio-economic indicators, which is associated with the lack of correlation between theoretical and practical blocks, as well as the effect of social stereotypes in society that determine the attitude to the economy as a science, which develops in a different plane than real life. We consider it necessary to use a systematic approach to the formation of the aforementioned competencies in the educational process, based on the progressive formation of knowledge that allows developing skills and forming skills brought to automatism. The given examples of tasks are actually used in the framework of teaching the discipline “Banking” in order to form economic competencies. The practical orientation of the tasks forms the ability to navigate in the economic situation and make decisions aimed at increasing income. In the recommendations on the organization of the educational process, emphasis is placed on the constant updating of information and economic indicators, since it is precisely during training in economic specialties that the relevance of information allows quite often to correlate your conclusions and arguments on the situation in the country, economic and banking sectors.
FEATURES OF THE ORGANIZATION OF PROJECT ACTIVITY OF PRIMARY SCHOOL STUDENTS
Authors: Кондакова Ирина Владимировна , Долгошеева Елена Владимировна , Корякина Галина Александровна
Published: June 2020

Рассматривается вопрос организации проектной деятельности в начальной школе как личностно ориентированной технологии, объединяющей в себе различные подходы, методы, методики. Даны характеристики основных сложностей, возникающих в процессе организации проектной деятельности, которые заключаются в неумении младших школьников, в связи с психолого-физиологическими особенностями развития, действовать самостоятельно и стремлении учителей давать прямые инструкции, подавлять и сдерживать инициативу обучающихся. Наиболее существенным фактором в процессе организации проектной деятельности с младшими школьниками является использование творческого, личностно ориентированного подхода, так как реализация каждого проекта предполагает наличие сотрудничества обучающегося и учителя, их сотворчества и совместного исследовательского поиска. Выделены и охарактеризованы основные проектные умения, сформированность которых свидетельствует о возможности успешной организации проектной деятельности с младшими школьниками. Приведены результаты исследования по выявлению уровня сформированности проектных умений у второклассников (поисковые умения, коммуникативные умения, умения и навыки работы в сотрудничестве, рефлексивные умения, организационно-практические проектные умения). Экспериментальное исследование проводилось в условиях учебного процесса при подготовке к организации проектной деятельности и выполнении различных диагностических заданий.

The article deals with the specifics of the organization of project activities in primary school, as a person-oriented technology that combines various approaches, methods, and techniques. The characteristics of the main difficulties that arise in the process of organizing project activities, which consist in the inability of younger students, due to psychological and physiological characteristics of development, to act independently and the desire of teachers to give direct instructions, to suppress and restrain the initiative of younger students, are given. The most significant factor in the process of organizing project activities with younger schoolchildren is the use of a creative, personality-oriented approach to the student’s activities due to the fact that the implementation of each project involves the student’s and teacher’s cooperation, their co-creation and joint research inquiry. The main project skills are identified and characterized, the formation of which indicates the possibility of successful organization of project activities with younger students. The results of a study to identify the level of formation of design skills in second-graders (search skills, communication skills, skills and working skills in collaboration, reflective skills, organizational and practical design skills) are presented. An experimental study was carried out in an educational process in preparation for the organization of project activities and the implementation of various diagnostic tasks.
READINESS OF FUTURE PRESCHOOL TEACHERS FOR MATHEMATICAL DEVELOPMENT OF CHILDREN: CONCEPT, STRUCTURE AND CONTENTS
Authors: Турова Ирина Валерьевна
Published: June 2020

Представлен анализ исследований по проблеме готовности будущих педагогов дошкольного образования к математическому развитию детей. Раскрыты основные подходы к сущности понятия «готовность». На основе проведенного анализа учебных планов направления подготовки «Психолого-педагогическое образование» профиль «Психология и педагогика дошкольного образования», а также профессионального стандарта педагога выделены компетенции, необходимые для осуществления математического развития детей дошкольного возраста. Готовность будущих педагогов дошкольного образования к математическому развитию детей рассматривается через системный, деятельностный и компетентностный подходы, что позволяет дать наиболее полное его определение и раскрыть разнопозиционность его формирования. Обобщая содержание психолого-педагогической литературы и диссертационных исследований по данной проблеме, выделены и охарактеризованы такие компоненты готовности будущих педагогов дошкольного образования к математическому развитию детей, как когнитивный, праксиологический и аксиологический. На основе выделенных компонентов определены критерии и уровни готовности.

The analysis of research works on a problem of readiness of future preschool teachers for mathematical development of children is submitted. The main approaches to the definition of the concept “readiness” are disclosed. Based on the analysis of curricula in the direction of preparation of “Psychological and Pedagogical Education” profile of “Psychology and Pedagogy of Preschool Education”, as well as the professional standard of the teacher, the competencies necessary for the implementation of the mathematical development of children of preschool age are distinguished. The readiness of future preschool teachers for the implementation of the mathematical development of children is considered through system, activity and competence-based approaches, which allows us to define this concept and consider the process of formation of this readiness from different angles. Generalizing the experience described in psychological and pedagogical literature and dissertation researches on this problem, the components of readiness of future preschool teachers for mathematical development of children, such as cognitive, praxeological and axiological are allocated and characterized. On the basis of the allocated components, criteria and levels of formation of this readiness are defined. The purpose of the article is to give an author’s idea of the structure and content of the professional readiness of future teachers of preschool education for the mathematical development of children.
Medical Learning Tool for Ventilator Weaning Protocols.
Authors: Mesa Agudelo Juan Camilo , Salazar Sánchez Maria Bernarda
Published: June 2020

Mechanical ventilation is one of the most used medical procedures in intensive care units across the world. In clinical practice, it represents a high level of complexity, especially in both stages, the extubation and weaning protocols. In order to enhance medical and nursing student's training skills regarding those topics, an interactive application was developed to teach basic information for ventilator weaning. The application has two fully graphic modules, which provide theoretical information and a set of clinical cases of patients under spontaneous breathing tests. It also includes information about medical records and interactive panels for weaning criteria and patient clinical condition during the weaning trials. A usability testing was performed with 12 subjects to validate the application usability, where the level of satisfaction with them showed that the app provides a straightforward tool to interact with the critical concepts of ventilator weaning.
Benefits and barriers to cooperation in the process of building a place?s brand: perspective of tourist region stakeholders in Poland
Authors: Kiryluk Halina , Glińska Ewa , Barkun Yauheniya
Published: June 2020

Research background: Cooperation within the public and the private sectors is one of the conditions for a tourist region to achieve a competitive advantage, and it is one of the most important aspect for building a regional tourist brand. Research studies often raise the issue of tourism cooperation; however, there are few papers undertaking this topic in the context of place branding. The issue of benefits and barriers of this type of cooperation seen from the perspective of the involved stakeholders is rarely the sole object of research and is often presented indirectly or implicitly.
Purpose of the article: The aim of the paper is to identify the benefits and barriers of cooperation seen by the local government and other representatives of regional tourism organization in the process of developing a regional brand.
Methods: To achieve the aim of the paper, the authors conducted a case study of a region, specifically Podlaskie Voivodship in Poland. This case study involved individual in-depth interviews conducted among representatives of organizations ? members of the Regional Tourism Organization.
Findings & Value added: The findings of this study contribute to a better understanding of cooperation between tourism entities in the process of regional place branding. The authors established a conceptual framework for systematization of benefits and barriers of cooperation as seen by regional stakeholders. The benefits were grouped into the following categories: economic, organizational, marketing and social; and the barriers included economic, organizational, socio-cultural and political determinants.
Impact of the global green factor on the capitalization of oil companies in Russia
Authors: Filimonova Irina , Komarova Anna , Mishenin Mikhail
Published: June 2020

Research background: This paper studies the impact of a new so-called green factor on the capitalization of petroleum companies, which is becoming highly relevant in view of the signing of the Paris agreements in 2015 and the support for clean energy. Although society, international organizations, and government authorities encourage companies to reduce their environmental impact, one of the main reasons for responsible behavior is still economic efficiency. The oil industry, on the one hand, faces one of the most volatile markets and, on the other hand, has one of the largest environmental impacts of any industry. That requires a detailed study of interconnections between market capitalization and the green factor.
Purpose of the article: A comprehensive study of factors affecting the level of capitalization of oil and gas companies in Russia and identification of the most significant among them with a special focus on the green factor.
Methods: Econometric analysis of panel data for Russian petroleum companies. The database includes indicators for six major Russian oil companies from 2011 to 2018. The following groups of factors are analyzed to explain the change in the companies? capitalization: macroeconomic (GDP and inflation in Russia), microeconomic (companies? revenue, net profit, tax payment, return on assets, return on equity, ratio of borrowed capital to equity), industrial (oil export, refining, production and proven reserves of the companies), and the green factor.
Findings & Value added: The selection of factors showed that the size of capitalization has been influenced most significantly by the following: the volume of the company's proven reserves, net profit, tax burden, and the green factor based on the policy of minimizing environmental damage. This result shows that investors consider companies with high environmental performance to be more valuable than companies with similar financial results but lower environmental ratings.
Economic efficiency of forming pike perch broodstocks in fish farms of Kazakhstan
Authors: Asylbekova Saule Zhangirovna , Badryzlova Nina Sergeevna , Koyshibaeva Saya Kashkinbayevna , Isbekov Kuanysh Baibulatovich
Published: June 2020

The article highlights the problem of the industrial press on the pike perch population in all reservoirs of Kazakhstan and the sharp decline in its population due to increased exports of pike perch to Europe, which led to the need to fill the shortage of fish stock by forming pike perch broodstocks in the fish farms and increasing the importance of aquaculture. There are presented the results of introducing the technology of pike perch broodstocks formation in conditions of the fish farm HalykBalyk, LLP, which is carried out in two ways: by a method of domestication that provides catching pike perches from the natural reservoirs and adopting the spawners to the con-ditions of the fish farm: by obtaining offspring from the wild pike perch producers and growing the seeding material in ponds with subsequent selection for the broodstock. There have been given the calculations and analysis of the economic efficiency of biotechnological techniques for the phased formation of the breeding stock of pikeperch in a fish farm. There are presented the data on the cost of domestication of pike perch producers harvested in the natural pond and transported from the fishing sites to the hatcheries, as well as fish products: fertilized eggs, larvae that switched to mixed feeding, raised juveniles, fingerlings and two-year-olds raised in polyculture with traditional fish species in ponds in order to form a breeding stock of pike perch by the ‘ab ovo’ method. A diagram of the production processes of forming pike perch broodstock is presented. To determine the economic efficiency of growing pike perch yearlings and two-year-olds in the ponds in polyculture with carp and grass carp, the general costing of ponds, specific production costs and data on fish catch in monetary terms are presented. A comparative analysis of the results has been held; the ways to reduce the cost of pike perch production at each stage have been indicated.
Current prospects of industrial use of valuable fish species in Lakes Kuito system (catchment area of the White sea)
Authors: Shirokov Vyacheslav Anatolievich , Georgiev Andrey Pavlovich , Cherepanova Nadezhda Stepanovna
Published: June 2020

Based on the results of our own field studies (Northern Research Institute of Fisheries in Petrozavodsk State University (formerly SevNIORH), Northern Water Problems Institute of the Karelian Research Centre of the Russian Academy of Sciences) and taking into account the available literature and archival information, we studied the long-term dynamics of catches of valuable fish species (salmon, lake char, whitefish, vendace) in Lake Kuito, assessed the current state of the populations and new biology data are provided. It was established that after the regulation of Lower and Middle Kuyto as a whole, changes in the structure of communities of valuable fish species against the background of underdeveloped fishing are not very noticeable, the commercial part of ichthyocenosis remains quite stable. The cessation of centralized fishing has created the conditions for amateur and paid recreational fishing, focused mainly on catching the most valuable fish species: salmon, pale, whitefish, vendace in the conditions of free fishing, existing at present. In the conditions of free fishing, it is proposed to amend the existing fishing rules in terms of establishing fishing measures for salmon (57 cm), fallow (40 cm), whitefish (20 cm) and changing the fishing measure to vendace (9 cm). At the present stage, in the conditions of the Kuito system (including tributaries), in terms of the developed forecasting the volumes of annual total allowable catches of valuable fish species have been determined in the following limits: salmon – 1 ton, lake char – 1 ton, whitefish – 5 ton, vendace – 40–50 ton. The boundary position of the Kuito lakes contributes to the tourist attractiveness and creating a modern tourist complex of natural significance
Monitoring sanitary state of perch (Perca fluviatilis L.) in open and closed water bodies of Volga basin
Authors: Stepanenko Elizaveta Aleksandrovna , Kanieva Nuria Abdrakhimovna , Grigoryeva Tatiana Nikolaevna
Published: June 2020

The article describes the main task of the sanitary-parasitological inspection as a timely detection of parasites and the degree of infection of fish raw materials in order to determine the eating properties or other use of fish products. Sanitary and parasitological study of the fish from the closed and open water bodies of the Astrakhan Oblast was carried out using perch (Perca fluviatilis L.)

as an example. There were studied 60 fish specimens (by 10 specimens in the autumn, winter, spring periods of 2018-2019) caught from the Sarbai River and the Shuralinskoye reservoir, with average weight of 110-182 g and length of 15-25 cm. There have been found dangerous nematodes (Anisakidae) and nematodes (Eustrongylides) – parasites that are not dangerous to human health, but significantly spoil the fish marketability. According to the results of comparative analysis of the extensiveness and permissible average number of parasites per 1 kg of fish, depending on the season and the type of reservoir, it was inferred that the Shuralinskoye reservoir is a safer reservoir

in terms of the prevalence of helminthes in perch than the Sarbai River. The fish from the reservoir can be eaten after sculling, gutting and the appropriate decontamination methods. The dynamics of fish parasites occurrence has been found to depend on the type of the water body and the season.
Descripción imagenológica de un caballo criollo colombiano con enfermedad articular degenerativa del tarso
Authors: Gallego-Rodríguez Renso Sneider , Álvarez-Mejía Claudia Patricia , López-Vera Luis Alejandro
Published: June 2020

En este artículo se reporta un caso clínico de una yegua criolla de 4 años, que llega a consulta por cojera y aumento de tamaño de la articulación del tarso en el miembro posterior derecho producto de un traumatismo. Se realiza examen clínico de la paciente en el cual se evidencia una claudicación de apoyo 5/5 con notables movimientos compensatorios; a la palpación refiere dolor y se evidencia tumefacción, aumento de temperatura y del tamaño. Se realizó hemograma, química sanguínea, evaluación del líquido articular por medio de citología y cultivo; a su vez, se realiza diagnóstico imagenológico mediante radiografía convencional y ecografía articular, el mismo se hace durante varios períodos de la evolución del caso, se realiza radiografía convencional en la cual se encuentran hallazgos como reacción proliferativa, presencia de osteofitos, anquilosis, entre otros; la evaluación ecográfica presentó hallazgos como disminución del líquido sinovial, aumento de tamaño y de ecogenicidad de la membrana sinovial y presencia de bandas de fibrina presentes en el líquido articular. El abordaje terapéutico se realiza mediante fármacos analgésico, lavado articular e infiltración con corticoides, e infusión intraarticular con DMSO al 10%. El presente caso describe el seguimiento imagenológico mediante ecografía y radiografía, hecho en un paciente equino con enfermedad articular degenerativa del tarso, lo cual entrega herramientas útiles a la comunidad veterinaria en el conocimiento y la interpretación de los cambios radiográficos y ultrasonográficos en un equino con enfermedad articular degenerativa durante el tiempo de evolución patológica.
Cellulose Nanocrystals Preparation as Pharmaceuticals Excipient : a Review
Authors: Putri Margaretha Efa , Chaerunisaa Anis Yohana , Abdassah Marline
Published: June 2020

Cellulose nanocrystals is a cellulose derivates which has been widely researched and observed as an chemical agent. Different with cellulose that has been widely used as pharmaceutical excipient especially in solid dosage form, cellulose in nanocrystals form is not available in pharmaceutical grade. Cellulose nanocrystals have different characteristics and quality which is depend on its preparation including sourcing, isolation procedure, and hydrolysis reaction involved. This difference is very important to deeply observed its impact in pharmaceutical dosage form with different active ingredients. In addition, cellulose nanocrystals should meet FDA requirement as pharmaceutical excipient. This review  describe cellulose nanocrystals preparation and its characteristics, its application to active pharmaceutical ingredients, and its properties in order to meet FDA requirement.Keywords: Cellulose, nanocrystals, pharmaceutical excipient
Characterization Methods of Amorphous Form Stability in Solid Dispersion : A Review
Authors: Butarbutar Maria Elvina Tresia , Wathoni Nasrul , Wardhana Yoga Windu
Published: June 2020

Solubility as a cause of ineffective active pharmaceutical ingredients (API) needs to be a concern. One of the solutions to increase the solubility by choosing active ingredients in the amorphous form. However, the amorphous form tends to be unstable because it has high Gibbs free energy and molecular mobility. To overcome those properties solid dispersion methods can be an answer. The dispersion of the amorphous form in the polymer is expected to prevent the transformation of API to crystal stable form. The solid dispersion (SD) resulted needs for physicochemical characterization to prove the ability of SD to maintain the amorphous form. Therefore, the physicochemical properties of the amorphous solid dispersions (ASDs) have to analyze there in any interactions that are able to occur between the drug and the polymer. Also for evaluate the stability of the ASDs within a certain period. In the article presents, some articles related with ASDs and its characterization will studying, include several product on the market as example. The number of literature used in this article is 69 articles.Keywords: Solubility, amorphous for, solid dispersion, characterization ASDs.
Riset aksi partisipatif: Festival kebudayaan menghadapi intoleransi
Authors: Adiprasetio Justito , Vinianto Andika
Published: June 2020

Indonesia saat ini mengalami ancaman gelombang intoleransi yang memprihatinkan, berbagai fakta lapangan seperti penyerangan tokoh agama, rumah ibadah dan berbagai persekusi, serta studi-studi pendahulu menunjukkan permasalahan tersebut. Mengacu pada strategi yang diterapkan oleh UNESCO, terdapat beberapa hal yang dapat dilakukan untuk melawan gejala intoleransi yaitu dengan meningkatkan pengetahuan melalui pendidikan berbasis multikulturalitas dan pluralisme, peningkatan kesadaran individu dan solusi lokal lain yang bersifat akar rumput. Ketiganya dapat dirangkum melalui pengadaan kegiatan kebudayaan: festival. Festival di berbagai negara, kerapkali digunakan untuk menanamkan nilai-nilai keberagaman: multikulturalisme dan pluralisme. Studi ini dengan menggunakan metodologi riset aksi partisipatif dan dikombinasikan dengan etnografi berupaya untuk menyusun pilot-project festival yang mempromosikan semangat toleransi. Partisipan dari penelitian ini adalah 600 mahasiswa yang berasal dari 5 program studi di Fakultas Ilmu Komunikasi (Fikom), Universitas Padjadjaran, yang sebelumnya telah mendapatkan mata kuliah Komunikasi Lintas Budaya. Hasil penelitian menunjukkan bahwa festival kebudayaan adalah sarana yang tepat untuk mengembangkan visi multikulturalisme dan pluralisme sekaligus menggeser narasi-narasi esensialisme kebudayaan. Riset ini membuktikan bahwa festival secara spesifik dapat ditargetkan untuk menyebarkan nilai-nilai toleransi, apabila memang partisipannya dilibatkan secara utuh dan berkesinambungan. Keberhasilan penyelenggaraan festival kebudayaan di Fikom menjadi jawaban dan pengejawantahan bahwa sangat mungkin festival-festival sejenis dapat diselenggarakan di tempat lain dengan tujuan yang sama, dan terutama menyasar generasi muda.
Pemanfaatan fitur media sosial Instagram dalam membangun personal branding Miss International 2017
Authors: Efrida Sella , Diniati Anisa
Published: June 2020

Media sosial saat ini selain sebagai media berkomunikasi dan berinteraksi, tetapi juga mendatangkan suatu fenomena baru sebagai wadah dalam melakukan personal branding. Salah satu media sosial yang sering digunakan dalam melakukan personal branding adalah Instagram. Kevin Liliana melalui akun Instagramnya @kevinlln melakukan pemanfaatan fitur pada Instagram untuk menampilkan identitas dirinya sebagai seorang Miss International 2017. Tujuan penelitian ini adalah untuk mengetahui bagaimana personal branding yang dilakukan oleh Kevin Liliana selaku Miss International 2017 dengan memanfaatkan media sosial Instagram. Penelitian ini menggunakan paradigma konstruktivisme yang bertujuan untuk menafsirkan makna-makna yang dimiliki oleh informan tentang suatu fenomena personal branding yang dilakukan oleh Kevin Liliana selaku Miss International 2017 yang terdapat pada fitur Instagram. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif. Teknik pengumpulan data penelitian ini berupa observasi, wawancara mendalam, dan dokumentasi. Hasil penelitian menunjukkan bahwa Kevin Liliana mendasari personal branding-nya secara authentic, dimana terdapat keselarasan antara apa yang ia tampilkan di media sosial dan kehidupan aslinya. Personal branding yang Kevin Liliana tampilkan sebagai Miss International 2017 yaitu sebagai beauty queen yang soft, humble, dan menonjolkan sisi behavior-nya. Kevin Liliana membangun personal branding melalui Instagram pribadinya @kevinlln ini tidak hanya berupa mengunggah konten personal branding, tetapi juga dengan berinteraksi dengan para pengikutnya melalui fitur Instagram agar pesan personal branding-nya dapat lebih cepat dan mudah tersampaikan. Secara keseluruhan, Kevin Liliana berhasil melakukan personal branding di media sosial Instagram, walaupun terdapat kekurangan, seperti engagement pada konten kegiatan sosialnya tidak lebih banyak mendapat respon seperti like dan comment dari pengguna lain.
Pengaruh Kualitas Produk dan Desain Terhadap Keputusan Pembelian Motor Yamaha Vixion
Authors: Aisyah Siti , Agustiawan Agustiawan , Nurwanita Nurwanita , Fatma Fatma
Published: June 2020

Tujuan penelitian ini adalah untuk mengetahuai kualitas produk dan desain berpengaruh secara parsial dan secara serempak terhadap keputusan pembelian motor yamaha vixion pada organisasi vixion di kota Palu. Lokasi pada penelitian ini di wilaya kota palu provinsi Sulawesi Tengah. Populasi dalam penelitian ini adalah seluruh anggota organisasi vixion di Kota Palu yang berjumlah 8 organisasi yaitu Vixion Young Riders Community, Rider Vixion Independen, Yamaha Vixion Club Indonesia, Vixion Jari-Jari Palu Vixion Ruji Squad Palu Celebes Vixion Club Dan Vixion Independen Club yang jumlah keseluruhan anggota 282 anggota. Teknik pengambilan sampel yang digunakan adalah teknik sample random sampling sebanyak 74 orang, dengan menggunakan rumus slovin untuk menentukan jumlah sampel. Teknik pengumpulan data adalah melalui teknik observasi, kuesioner, dan wawancara, SPSS 21 For Windows. Dan teknik analisa yang digunakan adalah analisis regresi linear berganda. Hasil penelitian ini menunjukkan bahwa variabel yang terdiri dari kualitas produk, dan desain secara serempak berpengaruh terhadap keputusan pembelian Motor Yamaha Vixion Studi Pada Organisasi Vixion di Kota Palu . Sedangkan, secara parsial desain berpengaruh secara signifikan terhadap keputusan pembelian Motor Yamaha Vixion Studi Pada Organisasi Yamaha Vixion di Kota Palu, sedangkan kualitas produk berpengaruh tetapi tidak signifikan. Nilai koefisien determinasi (R2) menunjukkan bahwa variabel independen yang diteliti mampu menjelaskan 11,3% pengaruhnya  terhadap variabel dependen (Keputusan Pembelian Motor Yamaha Vixion Studi Pada Organisasi Yamaha Vixion di Kota Palu, sedangkan sisanya 88,7% dijelaskan oleh variabel independen yang lain yang tidak termasuk dalam penelitian ini.
Tinjauan Ekonomi Islam Pada Prospek Industri Daur Ulang Sampah Plastik
Authors: Musyahidah Siti , Prasanti Nia Manora , Hasanah Uswatun , Ferdiawan Ferdiawan
Published: June 2020

Tulisan ini membahas permasalahan perekonomian masyarakat dan permasalah sampah yang semakin mengganggu di kota Palu. Metode yang digunakan dalam penelitian ini adalah: metode pendekatan kualitatif deskriftif yang berisi gambaran tentang latar pengamatan, orang, tindakan, dan pembicaraan. Adapun sumber datanya adalah informan yaitu ketua anggota dan beberapa anggota yang bekerja di industri Tondo Mandiri. Adapun analisis data yang digunakan dalam penelitian ini adalah analisis deskriftif dengan menggambarkan dan menginterprensikan data dan temuan-temuan yang peneliti peroleh dari lapangan serta fakta-fakta yang ada.  Hasil penelitian Tondo Mandiri tidak mempunyai prospek yang baik untuk kemajuan usaha kedepannya dikarenakan masalah dan hambatan yang dihadapinya. Kemudian ditinjau dari Ekonomi Islam Penulis memandang industri ini secara umum tidak bertentangan dengan ketentuan dalam syariat Islam, namun belum dapat sepenuhnya dikatakan sesuai dengan tinjauan Ekonomi Islam, karena ada beberapa hal yang dilakukan oleh para pekerja yang belum memenuhi syarat untuk dikatakan sesuai dengan aturan Syariat Islam.
Pengaruh Motivasi Terhadap Peningkatan Produktivitas Kinerja Karyawan Pada Tamzis Baituttamwil Area Yogyakarta
Authors: Nuriatullah Nuriatullah
Published: June 2020

Penelitian ini bertujuan untuk mengetahui pengaruh variabel-variabel motivasi terhadap peningkatan produktivitas kinerja karyawan, dan juga mengetahui variabel yang paling dominan terhadap produktivitas kinerja karyawan pada Tamzis Baituttamwil area Yogyakarta. Sampel yang digunakan adalah karyawan Tamzis Baituttamwil dimana jumlah sampel yang telah ditetapkan pada penelitian ini sebanyak 60 responden. Penelitian ini merupakan jenis penelitian lapangan yang bersifat deskriptif kuantitatif. Teknik pengumpulan data menggunakan metode pengumpulan angket, wawancara, dan dokumentasi. Hasil penelitian menunjukan bahwa Koperasi Jasa Keuangan Syariah Tamzis Baituttamwil secara umum telah menerapkan pemberian motivasi kepada karyawan. Hasil dari uji t (partial) menunjukan bahwa variabel motivasi berupa kebutuhan fisiologis, kebutuhan sosial, kebutuhan aktualisasi diri, kebutuhan penghargaan, kebutuhan spiritual, mempunyai pengaruh yang signifikan terhadap produktivitas kinerja karyawan. Adapun variabel yang berpengaruh dominan adalah variabel kebutuhan spiritual. Sedangkan untuk variabel kebutuhan keamanan tidak mempunyai pengaruh yang signifikan terhadap produktivitas kinerja karyawan. Hasil uji R2 (koefisien determinasi)  menunjukan bahwa variabel motivasi dapat memberikan kontribusi dalam mempengaruhi produktivitas kinerja  sebesar 80,7%. Sedangkan sisanya 19,3% dipengaruhi oleh faktor lain.
Pengaruh Gaya Kepemimpinan Dan Motivasi Kerja Terhadap Kinerja Karyawan Pada Bank Mandiri KCP Palu Imam Bonjol
Authors: Malkan Malkan , Adam Yusuf , Syafaat Muhammad , Sofyan Syaakir
Published: June 2020

Tulisan ini bertujuan untuk mengetahui  gaya kepemimpinan  dan motivasi kerja berpengaruh secara parsial dan simultan terhadap kinerja karyawan pada Bank Mandiri KCP Palu Imam Bonjol serta dari kedua variabel tersebut manakah yang paling berpengaruh terhadap kinerja karyawan. Populasi dalam penelitian ini adalah seluruh karyawan Bank Mandiri KCP Palu Imam Bonjol yang berjumlah 48 orang. Teknik pengambilan sampel yang digunakan adalah teknik sampel jenuh (saturation sampling), dengan menggunakan rumus sampel jenuh menurut Sugiyono. Teknik pengumpulan data adalah melalui teknik observasi dan kuesioner. Kemudian teknik analisa yang digunakan adalah analisi regresi linear berganda. Hasil olahan statistik yang dibantu dengan program SPSS 21 for windows, menunjukan bahwa gaya kepemimpinan dan motivasi kerja secara simultan berpengaruh terhadap kinerja karyawan pada Bank Mandiri KCP Palu Imam Bonjol. Sedangkan, secara parsial gaya kepemimpinan berpengaruh secara signifikan terhadap kinerja karyawan pada Bank Mandiri KCP Palu Imam Bonjol, sedangkan motivasi kerja berpengaruh namun tidak signifikan. Nilai koefisien determinasi (R2) menunjukan bahwa variabel independen (gaya kepemimpinan dan motivasi kerja) yang diteliti mampu menjelaskan 41,4% pengaruhnya terhadap variabel dependen (kinerja karyawan pada Bank Mandiri KCP Palu Imam Bonjol), sedangkan sisanya 58,6% yang dijelaskan oleh variabel independen yang lain yang tidak termaksut dalam penelitian ini.
STRATEGI PENGEMBANGAN USAHA AGROINDUSTRI KOPI LUWAK PADA SATRIA AGROWISATA DI KABUPATEN GIANYAR
Authors: Rosyanta Putu Marita Cakatini , Satriawan I Ketut , Sedana Yoga I Wayan Gede
Published: June 2020

This study aims to analyze the internal and external conditions as well as compose and recommend the business development strategy of agro-industries of Civet coffee at Satria agro- tourism in the Gianyar Regency. The methods used in this research is a method of observation field and in-depth interviews using questionnaire. Data field observations and interviews are then analyzed to obtain formulation strategies using the SWOT analysis. The assessment weighting and rating conducted by 5 experts. Results of the study show that there are 5 strengths, 5 weaknesses, 4 opportunities, and 3 threats. Results weighting and rating values for the matrix that the weighted Internal Factor Evaluation (IFE) was 3.72 and matrix External Factor Evaluation (EFE) is 3.75. This value indicates a strong position on the matrix Internal external (IE) and the strategy to do is intensive and integrative strategies. Based on SWOT Matrix Analysis, priority alternative strategy is maintaining of price and quality to expand marketing.

Keywords : strategy, SWOT, agro tourism, civet coffee, QSPM
ISOLASI DAN KARAKTERISASI KHAMIR POTENSIAL PENGHASIL BIOETANOL DARI INDUSTRI ARAK DI KARANGASEM BALI
Authors: Simbolon Nebay Cronika , Mahaputra Wijaya I Made , Wayan Gunam Ida Bagus
Published: June 2020

This research aimed to isolate and identify potential yeast of bioethanol-producer from arak industri in Karangasem Bali. The isolated sample was taken from 3 different points from 2 villages in Karangasem Bali. Isolation was carried out using PYG media then purified to obtain pure isolates. The pure isolates were screened with several stages, namely a qualitative test of gas production, growth selection with the addition of antibiotics, and quantitative tests with an alcohol oxidation reaction. Determind by UV visible spectroscopy, 9 potential isolates was obtained to continue to the identification stage. At this stage fermentation was carried out in PYG media for 10 days using a starter from a potential isolate with a media glucose level of 20% of the media volume. Fementation results were then distilled. Of the obtained 9 potential isolates the best isolate. IS 258 isolates are determind the best isolates with 86.85 mL ethanol. The total ethanol produced by IS 258 is higher than with 60.73 mL alcohol control experiment (Alcotec). Isolate IS 258 was isolated from bayur skin samples taken from the sap fermentation process. IS 258 then identified macroscopically and microscopically. Based on the results of macroscopic and microscopic identification, IS 258 has many similarities with previous studies on yeast isolation, isolate IS 258 is presumably the yeast genus Saccharomyces sp. Further research is needed to optimize ethanol production of IS 258 and identify species from isolates IS 258.

Keyword : bioethanol, Balinese wine, lau, yeast, isolation and identification of yeast, UV visible spectroscopy
ANALISIS PEMASARAN GARAM KUSAMBA DI KECAMATAN DAWAN, KABUPATEN KLUNGKUNG
Authors: Sega Neli Riyanti Dewa Ayu , Satriawan I Ketut , Bayu Sadyasmara Cokorda Anom
Published: June 2020

This research was carried out in Kusamba Village, Dawan District, Klungkung Regency. This study aims to find out to identify the salt kusamba marketing channel with the structure, conduct, performance (SCP) approach and analyze the marketing efficiency of kusamba salt. The data collected was analyzed with qualitative and quantitative methods. Qualitative methods are used to analyze marketing channels, structure, and market behavior, while quantitative methods are used to analyze market performance. Based on the results of the study, it can be concluded that the salt marketing process is through 4 (four) marketing channels. The market structure that occurs in the marketing of kusamba salt is oligopsonia. Market conduct occurs when the practice of pricing is still dominated by intermediary traders. Market performance shows that the highest total marketing margin is found in marketing channel 3 and the highest farmer share is found in marketing channels 1. The analysis of salt marketing efficiency based on farmer 's share states that the marketing channel 1 is the most efficient and based on the total marketing costs of marketing channel 3 is the most efficient because the value of Marketing Efficiency (EP) is 44,44% or ? 50%.

Keywords: Kusamba sea  salt, structure, conduct, performance, and  marketing efficiency
ANALISIS KEPUASAN KONSUMEN DENGAN MENGGUNAKAN METODE CUSTOMER SATISFACTION INDEX (Studi Kasus : C’Bezt Taman Griya)
Authors: Simanjuntak Pinondang , Satriawan I Ketut , Mulyani Sri
Published: June 2020

The purpose of this study was to know the attributes that are considered important by consumers and to know the level of customer satisfaction at C'Bezt Taman Griya. The method used is Slovin Method for determining samples and customer satisfaction index (CSI) method for data processing. Tests for reliability and validity were carried out at Jaya Fried Chicken Siligita and research site in C’Bezt Taman Griya. The number of samples used was 97 respondents. The attributes that are considered important by consumers based on the level of importance are the taste of food, the behavior of employees in serving consumers, and cleanliness of the location. Based on the level of satisfaction is the speed in serving consumers, taste of food, seriousness in serving consumers. The level of customer satisfaction C'Bezt Taman Griya is 74.63% with the level of Customer Satisfaction criteria that is satisfied.

Keywords: Consumer Satisfaction, Consumen Satisfaction Index, C’Bezt.
ANALISIS KELAYAKAN FINANSIAL USAHA BUDI DAYA IKAN LELE DUMBO (Clarias gariepinus) DI KOLAM TERPAL DAN KOLAM PERMANEN PADA UD. REPUBLIK LELE KABUPATEN KEDIRI
Authors: Abidin Zainal , Suryawan Wiranatha A.A.P. Agung , Mulyani Sri
Published: June 2020

The purpose of the study was to analyze the financial feasibility of Clarias gareipinus cultivation in tarpaulin ponds and permanent ponds UD. Republik Lele in Kediri Regency, East Java. The method used is the analysis of profit-loss calculations using the Net Present Value (NPV), Internal Rate of Return (IRR), Net B / C Ratio, Pay Back Period (PBP), and Break Event Point (BEP). The results of the study show that. The results showed that the stages of catfish cultivation included the process of spawning, catfish egg hatching, seed grading, and the augmentation process. Spread density in permanent ponds of 500 seedlings / m2, tarpaulin ponds of 450 seedlings / m2 as a whole the business of profitable catfish cultivation, with an average net pool profit of Rp. 23,918,347 / cycle / pond and tarpaulin pool Rp. 19,005,054 / pool / cycle. Based on the analysis of financial feasibility of permanent ponds and tarpaulins in a row generate (NPV) Rp. Rp 5,975,446,295 and Rp 1,645,894,923 (IRR) of 17.62% and 10.57%, (PBP) for 3 years and 3 years 9 months, Net B / C Ratio of 1.20 and 1.19, and (BEP) in the amount of Rp. 11,082,314,678 and Rp. 8,238,792,702/year. This business is feasible to be developed.

Keywords: financial feasibility, tarpaulin pool, permanent pond, catfish
STRATEGI PENGEMBANGAN PRODUK AGROINDUSTRI PADA AREA BELANJA Di AGROWISATA CAU CHOCOLATE FACTORY
Authors: Trisnayanti Ni Made , Satriawan I Ketut , Sedana Yoga I Wayan Gede
Published: June 2020

Agrotourism is a tourist activity that involves the use of agricultural land or related facilities that attract tourists. The increasing number of agrotourism will have implications for the level of competition that is increasingly high among agrotourism. The high competition is one of the factors to carry out product development strategies. The objectives purpose of this study are: 1) to find out the types of agroindustry products sold in the shopping area in agrotourism, 2) determine which agroindustry products are most popular with tourists in the shopping area, 3) to formulate alternative strategies and set priorities for agroindustry product development strategies. This research was conducted at Cau Chocolate Factory Agrotourism. This study uses the SWOT method to determine the alternative strategies used, and TOPSIS to rank these alternatives. The strategy that can be applied in Cau Chocolate Factory Agrotourism is a intensive strategy, the priority of the chosen strategy is 1) expanding the marketing of chocolate products, 2) promoting processed chocolate products to social media, 3) strengthening cooperation with suppliers and between tourism actors and similar companies.

Keywords: Agrotourism, Agroindustry, SWOT, TOPSIS, Chocolate Factory