bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of an Interface in MATLAB for Trend Analysis of Hydro-Meteorological Data
Authors: Patil J. P. , Sarangi A. , Singh D. K.
Published: November 2019

This study presents an interface, ‘Climate Change Trend Analysis (CCTA)’, developed in MATLAB® environment to analyze the trends using non-parametric statistical methods, Mann-Kendall (MK) test and modified Mann-Kendall (MMK) test with Sen’s slope estimator. The interface was used to determine trend in annual and seasonal (kharif) rainfall depths in Pune district acquired from 13 observatories. The developed interface automates the trend analysis process, which can further use for detecting variability and trends in the meteorological as well as other hydrological and agricultural parameters. The observed rainfall trends during monsoon would play a significant role for rainfed agriculture in Pune district.
Screening of Fluorescent Pseudomonad Isolates Against Sclerotium Rolfsii Sacc., of Soybean (Glycine Max)
Authors: . Priyanka , Goudar Geeta.
Published: November 2019

An attempt was made to isolate and characterize Fluorescent pseudomonads from the rhizosphere soil samples and further screening of the isolates for their antagonistic properties against Sclerotium rolfsii Sacc., of soybean. The isolates were subjected for morphological, biochemical and functional characterization. All the isolates exhibited fluorescence under UV light. Cells were rods and gram negative. All the isolates produced clear zone of P- solubilization (TCP) (18.80-21.71mm diameter) on Pikovskaya’s agar medium. The fluorescent pseudomonads produced significantly varying quantities of IAA (19.97 mg to 28.89 mg IAA/25 ml of broth) and GA (18.52 µg per 25 ml broth). All the isolates showed antagonistic activity against Sclerotium rolfsii. The per cent inhibition ranged from 36.85 to 70.37. Under pot culture experiment, lowest PDI was observed in DFP48 followed by DFP47, among the FP isolates. These isolates also showed maximum peroxidase activity and also plant growth promotional activities.
Evaluation of green gram genotypes for drought tolerance by PEG (polyethylene glycol) induced drought stress at seedling stage
Authors: Jincya M. , Prasad V. Babu Rajendra , Jeyakumara P. , Senthila A. , Manivannan N.
Published: November 2019

Drought stress is one of the major constraints for pulse production which negatively affecting its growth and production. Screening and selection of desirable genotypes for drought tolerance is the first and foremost important step in pulse breeding program. In green gram standardization for moisture stress was done under laboratory conditions using various concentration of PEG 6000 and 50% seedling mortality was observed at 0.5 MPa of moisture stress. Using this level of moisture stress 108 green gram genotypes were screened for their drought tolerance at seedling level and the following parameters viz., germination percentage, promptness index, radicle length, root length stress index, germination stress index and seed vigour were recorded. Observations revealed that the following green gram genotypes COGG 1332, VGG 16069, VGG 17003, VGG 17004, VGG 17009, VGG 17019 and VGG 17045 were found highly tolerant to moisture stress at seedling stage.
MOLECULAR HYDROGEN: BIOLOGICAL EFFECTS, POSSIBILITIES OF APPLICATION IN HEALTH CARE. REVIEW
Authors: Rakhmanin Yu. A. , Egorova Natalija A. , Mikhailova R. I. , Ryzhova I. N. , Kamenetskaya D. B. , Kochetkova M. G.
Published: November 2019

Hydrogen (H2) is the lightest and most common element in the universe. In molecular form, (H2) is a colorless, odorless, tasteless and non-toxic gas. For a long time, hydrogen was considered physiologically inert until its ability to reduce the intensity of the negative effect of oxidative stress was detected. According to modern concepts, oxidative stress affecting cells and tissue to be damaged, aged and causing a number of diseases - cardiovascular, rheumatic, gastrointestinal, neurodegenerative, oncological, metabolic and other. Antioxidants, however, have had limited use in the prevention and treatment of oxidative stress-related diseases due to the high toxicity and low efficacy of many of them. Therefore, it remained necessary to identify effective antioxidants with little-to-no side effects. Since 2007, discovery molecular hydrogen (H2) to possess selective antioxidant properties, multiple studies have demonstrated H2 to show beneficial effects in diverse human disease (such as digestive, cardiovascular, central nervous, respiratory, reproductive, immune, endocrine systems diseases, cancer, metabolic syndrome, and aging). H2 is a specific scavenger of •OH, which is a very strong oxidant that reacts with nucleic acids, lipids, and proteins, resulting in DNA fragmentation, lipid peroxidation, and protein inactivation. Fortunately, H2 does not appear to react with other ROS having normal physiological functions in vivo. Due to its mild but effective antioxidant properties, H2 can reduce oxidative stress and cause numerous effects in cells and tissues, including anti-apoptosis, anti-inflammatory, anti-allergic and metabolic effects. This review discusses H2 biological effects, describes effective H2 delivery approaches and summarizes data on the results and prospects of H2 applications in the prevention of human diseases and therapy.
SOMATOTYPOLOGICAL FEATURES OF STUDENTS IN THE CONDITIONS OF RADIATION EXPOSURE TO THE ENVIRONMENT
Authors: Litvin Fedor B. , Dorofeev V. V. , Zhigalo V. Ya. , Bykova I. V. , Nikityuk D. B. , Klochkova S. V.
Published: November 2019

Introduction. The state of health and the level of physical development of modern youth is updated as the steady balance of environmental factors is disturbed. Issues of ecology and human survival are included in the line of priority world problems. The purpose of the study was a comparative study of the somatotypological features of boys and girls from different radioecological places of residence. Material and methods. The study involved 396 young men and 320 girls from radioecologically disadvantaged regions (REDR) of the Bryansk region and 970 young men and 962 girls from radio-ecologically safe regions, the age of cases varied from 17 to 22 years. There were determined following main somatometric indices: length and body weight, chest circumference (CC). There was calculated a Pignet index (PI), characterizing the strong-built and body mass index (BMI, kg/m2). Information was processed using the Statistika 6.0 application package. Results. According to the results of the work, the somatotypological features of the organism largely were shown to depend on the living conditions in which the genetic program of the individual’s development was installed. The calculated data showed the total dose of radiation during their stay in radioecologically to contaminate areas in the range from 35.7 mSv to 43.52 mSv. Low doses of radiation along with socio-economic factors influence the growth and development of the organism, which is manifested by a change in the number of boys and girls with “extreme” variants of somatotypes. In REDR the number of asthenics and hypersthenics increased by 2 times a decrease by 2 correspondingly. Boys have an increase in body weight, a decrease in CC, and presented short stature. Regardless of the somatotype, the index of body strength and BMI decreases. In girls, the number of asthenics increased by 1.4 times and the number of hypersthenics decreased by 1.5 times. The disharmony of development is manifested in an increase in body length with a decrease in CC. The weight varies in different directions. Body strength and BMI are reduced unidirectionally. In general, the dynamics of indices of physical development in girls indicates a more pronounced resistance of the female body to the effects of low doses of radiation. Conclusion. The results of the study showed that small doses of radiation along with other social and economic factors influence the level of metabolic processes in the growing organism of young men and women, which is accompanied by changes in the morphological characteristics that underlie the somatotypological features.
VIBRIO CHOLERA IN THE WATERS OF THE RUSSIAN FEDERATION
Authors: Kruglikov V. D. , Levchenko Daria A. , Titova S. V. , Moskvitina E. A. , Arkhangelskaya I. V. , Gaevskaya N. E. , Ezhova M. I.
Published: November 2019

The current stage of development of the seventh pandemic of cholera in the world is characterized by a tendency to widespread, registration of outbreaks, epidemics and sporadic cases of diseases associated with drifts, including single drifts of this infection (without spreading) into Russia. The territory of Russia is one of the most water-supplied countries in the world; however, some of the rivers, such as the Volga, Ob, Amur, and Don are among the most important economic arteries, therefore just these rivers were the objects of study for this work. A comparative multivariate analysis of data from long-term monitoring studies on cholera showed that in all the studied reservoirs during the study period there was observed the isolation of cultures of Vibrio cholerae with diverse phenotypic characteristics. The data obtained allows us to tentatively assume that in Russia there are a number of areas with aquatic ecosystems, such as r. Volga, Ob, Amur, and Don, in which non-toxic cholera vibrios can survive during the summer period. In the microbiological aspect of cholera epidemiological surveillance, the accumulation of long-term data on the circulation of Vibrio cholera strains in environmental objects is important. From our point of view, the use of computer technologies (Geoinformational System) for analyzing the dynamics of the isolation of V. cholerae cultures in both spatial and temporal formats contributes to the timely determination of the direction and volume of preventive measures in each specific administrative territory of the country.
HYGIENIC ASSESSMENT OF WORKING CONDITIONS OF EMPLOYEES IN THE TEST LABORATORY CENTER OF THE OFFICE OF FEDERAL SERVICE FOR SUPERVISION OF CONSUMER RIGHTS PROTECTION AND HUMAN WELL-BEING
Authors: Vazhenina A. A. , Trankovskaya Lidiya V. , Anishchenko E. B.
Published: November 2019

A comprehensive hygienic assessment of the working conditions of the Test Laboratory Center employees in the «Center for Hygiene and Epidemiology in Primorsky Krai» was executed. Instrumental studies of the air in the working area have been performed, the levels of production noise, general vibration, microclimate parameters, light environment, non-ionizing electromagnetic fields, and radiations have been measured, time-related studies have been carried out to study the severity and intensity of the work process at workplaces in the structural subdivisions of the microbiological laboratory and the Department of sanitary and hygienic laboratory research. The biological factor at the workplaces for employees of the microbiological laboratory was studied. Harmful production factors were identified at the workplaces of the Test Laboratory Center of the office of The Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, and their hygienic assessment was given. Based on the results of the general hygienic assessment the 3rd grade of working conditions of degree 3 was established in the microbiological laboratory and in the Department of sanitary and hygienic laboratory research there was the 3rd grade of working conditions of degree 1.
REGIONAL FEATURES OF THE MORPHOFUNCTIONAL DEVELOPMENT OF STUDENTS OF KAZAKH NATIONALITY
Authors: Bazarbaeva Saule M. , Dinmukhamedova A. S. , Aizman R. I.
Published: November 2019

Aim. To study the features of the morphofunctional development of the Kazakh nationals of the first year of the M. Kozybaev North Kazakhstan State University arrived for training from the northern and southern regions of Kazakhstan with the goal of developing preventive measures to reduce the adaptive stress to university education. Material and methods. The study involved 400 first-year students 17-18 years old, of both genders, studying at different faculties of the M. Kozybaev North Kazakhstan State University (200 girls and 200 boys) who arrived from the northern and southern regions of the republic. Standard methods of determining anthropometric and functional indices, estimating the adaptive potential and the level of physical health were used. The resulting material is processed by the methods of ANOVA statistical methods. Results. Indices of physical development (length, body weight, chest circumference, Quetelet, Pinje and stenius indices) were shown to be within the age-gender norms, but a comparative assessment of physical health of students showed significant differences in the anthropometric and physiological state depending on the previous area of residence. Thus, the length of growth in northerners was higher than that of southerners. The indices of body weight, chest circumference, and the Quetelet index are higher in representatives of the southern regions. By the type of body build, among the girls and boys hypersthenics predominated in the southern region, normostenics - in the northern region. At the same time, with an increase in the constitution, the absolute and relative values of force indices and the vital index increased. At the same time, students in the southern region had a lower functional reserve of the heart, determined by the magnitude of the double product, the heart rate, and blood pressure. For students of the northerners of both genders, satisfactory adaptation (1st “level of health”) is typical, whereas representatives of the Southern Region had a lower level of adaptive potential, which corresponded to the state of exertion of adaptation mechanisms. Conclusion. Comparative evaluation of morpho-functional indices of the body of students of adolescence revealed features of body size, type of constitution, functional reserves of the cardiorespiratory system depending on the previous region of residence. The data obtained can be used to compile standards for the physical development of young people of different regions of the republic and the development of health programs to reduce adaptive stress.
CONTENTS OF MAGNESIUM IN THE ENVIRONMENT AND POPULATION MORBIDITY RATE OF ARTERIAL HYPERTENSION
Authors: Yahyaev M. A. , Salikhov Shamil K. , Abdulkadyrova S. O. , Aselderova A. Sh. , Surkhayeva Z. Z. , Kazanbiyeva P. D. , Ibragimova E. I. , Alieva D. Z. , Adilova M. A. , Abusueva B. A. , Abusueva Z. S.
Published: November 2019

Introduction. Study of the interrelation between magnesium content in biosphere objects (soil, natural water, plants) with arterial hypertension (AH) incidence among the population living in the territory of the plain Dagestan (Babayurtovsky, Kizlyar, Tarumovsky and Nogai districts of the Republic). material and Methods. To assess the development of hypertension, the data were obtained from the medical information center of the Ministry of Health of Dagestan. Samples of soil, water, plants with the determination of the magnesium content in them were processed by the photometric method in the biogeochemical laboratory of the Prikaspiyskiy Institute of Biology Resources of Daghestan Scientific Centre of the Russian Academy of Sciences. For analyzes, the material was selected in the summer months. The correlation coefficients are calculated by Pearson. Results. When comparing the incidence rates of AH for 2005-2007 with the magnesium content in soils, natural waters, plants, a negative average correlation of magnesium concentration in the study sites with the incidence of AH population was established in the study area. A number of patients in the studied years was also noted to be changing, but the dependence of the incidence of AH of the population on the magnesium content in the biosphere objects is preserved. Conclusions. One of the factors of occurrence and course of hypertension is the magnesium status of the population, which depends on the geochemical features of the territory. As a result of the study, it was found that the higher the magnesium content in biosphere objects, the lower the incidence of AH population. In order to reduce the AH values among the population, it is necessary to correct the lack of magnesium in the human body with magnesium additives, which contribute to the regulation of blood pressure and reduce the risk of cardiovascular diseases. In connection with the possible subclinical magnesium deficiency, an important factor in informing about the possible morbidity of hypertension is information on the magnesium content in environmental objects.
HYGIENIC RISK FACTORS OF PHYSICAL CULTURE AND SPORTS ACTIVITY OF ATHLETES. THE COACH’S VIEW
Authors: Davletova Nailya Ch. , Tafeeva E. A.
Published: November 2019

The article presents an overview of hygienic risk factors that affect the health of athletes. There were analyzed and ranked main risk factors for the health of athletes associated with physical culture and sports activities in 25 sports. During the research, 223 trainers were interviewed. As a result of the analysis, hygienic risk factors were concluded t0 be associated with microclimatic and other conditions in training and competition in halls/sports facilities are most often observed in cyclical sports (75.6%), sports games (63.3%), complex coordination sports (59.7%). Hygienic risk factors associated with compliance with personal hygiene, diet and drinking regimens are encountered in recreational sports (46.7%), martial arts (19.1%) and sports games (18.1%). Hygienic risk factors associated with sports equipment and inventory are more typical for recreational sports (40%), martial arts (32.8%) and hard-coordinated sports (28.6%).
Case Report: Prolonged Excretion of Platinum in Human Breast Milk After Cisplatin Therapy
Authors: Canale Stephanie , Duffy Jennifer , Chang Chong Hyun , Damoiseaux Robert
Published: November 2019

Introduction

Cisplatin is used to treat cancers that affect women of childbearing age and those that may breastfeed. Prior literature regarding the duration of cisplatin excretion in human milk is sparse and suggests complete clearance days after initial administration.

Method

We present the case of a postpartum woman who received three doses of weekly cisplatin for cervical cancer. Platinum levels were measured in expressed milk for several months after cisplatin administration.

Results

Levels of the parent element platinum were detected 159 days (over 22 weeks) followingadministration. These results demonstrate persistence of detectable platinum levels for a muchlonger period than previously reported.

Conclusion

This case report is the first to follow platinum levels in expressed milk after multiplepostpartum cisplatin doses. Our results demonstrate a biphasic elimination with detectionspanning several months after cessation of treatment. Women should be advised to abstainfrom breastfeeding until long after completion of cisplatin therapy.
Anti TNF tedavisi seyrinde gelişen üveitler: primer hastalıktan mı ilaçtan mı?
Authors: ARSLAN Didem
Published: November 2019

Anti-TNF ilaçlar, non-enfeksiyoz üveit için günümüzde etkinliği kanıtlanmış yaygın kullanılan tedavilerdir. Mevcut tüm anti-TNF ilaçların üveit tedavisinde olumlu etkileri bildirilmiştir. Ancak retrospektif ve gözlemsel çalışmalarda etanersept tedavisi sonrası düşük etkinlik veya paradoksal etkiye bağlı olarak üveit gelişimi bildirilmiştir. Paradoksal reaksiyonlar, Anti-TNF tedavisi sırasında, bu ilaca bağlı olarak gelişen ve genellikle bu grup ilaçlara yanıt veren patolojik durumlar olarak tanımlanır. Paradoksik üveit tedavisini, hastaların altta yatan hastalığının ve üveitin durumları ve hastanın demografik verileri belirlemelidir.
Anti-TNF tedavi seyrinde gelişen otoimmün hastalıklar: Eşlik eden hastalık mı? İlaca mı bağlı?
Authors: ÇELİK Selda
Published: November 2019

Anti-TNF tedavilerin romatolojik ve otoimmün hastalıkların tedavisinde yaygın kullanımı ve uzun dönem takipleri ile birlikte, paradoksal olarak anti-TNF ilişkili otoimmün hastalıklarla ilgili artan sayıda bildiriler olmaktadır. Bu ilaçlar genelde ağır hastalık aktivitesi olan romatolojik hastalarda kullanıldığından, bazı durumlarda bu gelişen hastalıkların altta yatan hastalığa da bağlı olabilmesi ile ilgili çelişkiler bulunmaktadır. Giderek artan vaka serilerinden elde edilen bilgiler ışığında bu konuyu tartışmayı amaçladık
Osteoartrozda yeni tedavi yöntemleri
Authors: ÖZER Diren , EYİGÖR Sibel
Published: November 2019

Osteoartroz (OA) en yaygın artrit şeklidir. OA'da klinik çalışmaların sunduğu birçok zorluğa rağmen, hastalık patogenezi, hastalık süreci ve ağrının tedavisinin yanı sıra altta yatan hastalığın tedavisinde birçok yeni farmakolojik tedaviler ve klinik araştırmalar vardır. Yeni farmakolojik ajanlar ile klinikte OA'da semptomların ve hastalık sürecinin iyileştirilmesine yönelik fırsatlar ufukta görünmektedir.
Waldemar Henrique, um compositor paraense: regionalismo e interações com os nacionalismos de Mário de Andrade e Getúlio Vargas
Authors: Aguiar Geam Gonçalves , Clímaco Magda De Miranda
Published: November 2019

Waldemar Henrique, compositor paraense, em muitas de suas composições investiu na cultura popular da Amazônia, em sua música, seus mitos e crenças, o que o caracterizou como um compositor regionalista. As primeiras análises de sua trajetória de vida e de sua trajetória musical, no entanto, levaram a considerar que teve oportunidade de dialogar também com os nacionalismos de Mário de Andrade e de Getúlio Vargas. Daí este trabalho ter objetivado investigar como se deu o diálogo do compositor regionalista com os nacionalismos marioandradiano e getulista com os quais teve contato e como estes nacionalismos se evidenciaram em duas canções que compôs: Minha Terra e Uirapuru. Uma canção do início de sua carreira em Belém (PA) e uma canção composta durante a sua residência no Rio de Janeiro, o que possibilitou verificar que já havia sintonizado com os movimentos nacionalistas que ocorriam no eixo Rio/São Paulo, mesmo antes de domiciliar-se nessa região. Levando em consideração este contexto descrito, os processos de interação com diferentes dimensões culturais que Waldemar Henrique efetivou, as análises musicais realizadas e a fundamentação teórica adotada, foi possível estabelecer uma relação de seu trabalho com uma “construção simbólica da nação”. “Construção simbólica da nação” sujeita à transversalidade de diferentes poderes, ao entrecruzamento de um sistema de representações, onde sentidos e significados relacionados a uma cultura popular interagem, diretamente ou não, com intenções e interesses políticos e/ou ideológicos.
Perspectivas teóricas para el análisis de la maternidad adolescente
Authors: Hernández Cordero Ana Lucía , Gentile Alessandro , Santos Díaz Estela
Published: November 2019

En este artículo revisamos la literatura más destacada y reciente (española e internacional) que aborda los embarazos y la maternidad en edad adolescente desde el ámbito médico-sanitario y desde las ciencias sociales. Identificamos dos marcos analíticos que insisten, respectivamente, en las consecuencias bio-psico-sociales de la maternidad adolescente y en los elementos estructurales que la reproducen en distintos contextos socio-económicos y culturales. Nuestro objetivo es sistematizar las contribuciones de estos dos marcos teóricos y plantear una tercera perspectiva que da cuenta de la maternidad adolescente como experiencia subjetiva de estas mismas jóvenes madres.
Teodora Castro Hernández. Itinerarios de poder y liderazgo. La voz de las mujeres. Badajoz: Instituto de la Mujer de Extremadura. 2018. 254 pp.
Authors: Franco Martínez J. Agustín
Published: November 2019

Reseña del libro de Teodora Castro.
Discriminación, apoyo social y bienestar psicológico en personas con trastornos mentales
Authors: Suárez Vergne Álvaro
Published: November 2019

En esta investigación se estudian los discursos y prácticas relacionados con la salud mental en la ciudad de Sevilla observando la influencia de estos sobre el bienestar psicológico de sujetos con trastornos bipolar y depresión. No sólo se trata de visibilizar un fenómeno de gran importancia de cara al futuro sanitario, sino que se hace desde una perspectiva diferente, una perspectiva social. Frente a enfoques hegemónicamente biologicistas en el abordaje de la salud, la visión de las ciencias sociales puede enriquecer notablemente el conocimiento respecto al tema tratado, generando oportunidades difíciles de ver desde otras posiciones.

Se emplea una metodología cualitativa que pone en evidencia la variabilidad discursiva de cara al fenómeno estudiado, así como la influencia positiva del apoyo social sobre el bienestar psicológico de sujetos con trastornos mentales.
elecciones europeas de 2019 y las fake news
Authors: Pira Francesco
Published: November 2019

La comunicación en Italia en las últimas elecciones europeas marca la victoria del algoritmo sobre valores y contenidos y reafirma el peso muy fuerte dado por las fake news en todo el proceso de conocimiento sobre programas y candidatos. Una comunicación más inclinada al retorno de una propaganda entre populismo y soberanismo. La encuesta sobre la comunicación de los partidos políticos en Italia atestigua este cambio de tendencia y destaca las derivas que refuerzan en la red el malismo, el individualismo y el conocimiento limitado por las distorsiones generadas por las cascadas informativas.
Paper versus Screen: Impact on Reading Comprehension and Speed
Authors: Ely Shuhadah Tajuddin  , Fitri Suraya Mohamad
Published: November 2019

Choosing the appropriate reading format is important for students to achieve effective reading. This quasi-experimental study investigates the effects of paper versus screen on reading comprehension and speed among undergraduate students who are currently enrolled in a public university in Sarawak. The general objective of this study is to investigate the formats for effective reading and comprehension among undergraduates. Instruments that have been used in this study were a set of questionnaires, a set of general interest articles, corresponding comprehension questions, and an online timer.  Findings revealed that students tended to have better reading comprehension when reading on the screen. Conversely, students were able to read faster using the paper format. Data also revealed that there is significant difference between paper and screen formats for both reading comprehension and reading speed.
Genre-Based Aproach in L2 Writing Classroom
Authors: Rasyidah Nur
Published: November 2019

This conceptual paper is aimed at examining the application of genre theory to an L2 classroom in a local university in Malaysia in the learning of specialized vocabulary in a food writing course. All three types of genre theory will be discussed, namely literary, rhetoric and linguistic genre theory to give a holistic understanding of genre. This will allow the coverage of both similarities and differences through all disciplines, and subsequently inform the richness of these theories, how it can be applied, and the significance of using these genre theories in the ESL writing classroom. This paper will also discuss the relationship between genre approach and genre writing and its application in the food writing classroom.
Students’Perceptions on Program Learning Outcomes: A Secondary Data Analysis of An Exit Survey
Authors: Nik Mohd Yusoff Nik Nadhilah
Published: November 2019

Outcome based education (OBE) emphasized on designing, constructing, delivering and documenting the teaching and learning to be in line with the established program learning outcomes (PLO) by the Malaysian Qualification Framework (MQF) to improve the quality of learning. The study focuses on students’ perceptions on the PLO at the School of Quantitative Sciences (SQS), Universiti Utara Malaysia.A secondary data from an exit survey among graduating students of SQS has been analysed for this purpose. Study finding shows that on average, all respondents perceived that they werefairly strongly to strongly for all PLOs. The information obtained from the exit survey data is able to rank the PLO by its corresponding mean value in decreasing order.The purpose of this study is to obtain information on the extent to which the students have mastered the skills (PLO) from their own view.This study has been done by secondary data collection. The secondary data was from a 2017 Exit Survey with 46 respondents among graduating students of SQS, UUM. All of these students were enrolled in Bachelor of Science with Honors (Business Mathematics) program.All respondents perceived that they were at fairly strong to strong level for all PLO. The information obtained from the exit survey data is able to rank the PLO by its corresponding mean value in decreasing order.This study will be beneficial to curriculum providers as a reference for improvement by understanding the needs and current states of the students. Moreover, this research will provide recommendations on how to evaluate program learning outcomes.
Does fluvial channel-belt clustering predict net sand to gross rock volume? Architectural metrics and point-pattern analysis of a digital outcrop model
Authors: Koch Alexander R. , Johnson Cari L. , Stright Lisa
Published: November 2019

Spatial point-pattern analyses (PPAs) are used to quantify clustering, randomness, and uniformity of the distribution of channel belts in fluvial strata. Point patterns may reflect end-member fluvial architecture, e.g., uniform compensational stacking and avulsion-generated clustering, which may change laterally, especially at greater scales. To investigate spatial and temporal changes in fluvial systems, we performed PPA and architectural analyses on extensive outcrops of the Cretaceous John Henry Member of the Straight Cliffs Formation in southern Utah, USA. Digital outcrop models (DOMs) produced using unmanned aircraft system-based stereophotogrammetry form the basis of detailed interpretations of a 250-m-thick fluvial succession over a total outcrop length of 4.5 km. The outcrops are oriented roughly perpendicular to fluvial transport direction. This transverse cross-sectional exposure of the fluvial system allows a study of the system's variation along depositional strike. We developed a workflow that examines spatial point patterns using the quadrat method, and architectural metrics such as net sand to gross rock volume (NTG), amalgamation index, and channel-belt width and thickness within moving windows. Quadrat cell sizes that are ∼ 50% of the average channel-belt width-to-thickness ratio (16:1 aspect ratio) provide an optimized scale to investigate laterally elongate distributions of fluvial-channel-belt centroids. Large-scale quadrat point patterns were recognized using an array of four quadrat cells, each with 237× greater area than the median channel belt. Large-scale point patterns and NTG correlate negatively, which is a result of using centroid-based PPA on a dataset with disparately sized channel belts. Small-scale quadrat point patterns were recognized using an array of 16 quadrat cells, each with 21× greater area than the median channel belt. Small-scale point patterns and NTG correlate positively, and match previously observed stratigraphic trends in the fluvial John Henry Member, suggesting that these are regional trends. There are deviations from these trends in architectural statistics over small distances (hundreds of meters) which are interpreted to reflect autogenic avulsion processes. Small-scale autogenic processes result in architecture that is difficult to correlate between 1D datasets, for example when characterizing a reservoir using well logs. We show that 1D NTG provides the most accurate prediction for surrounding 2D architecture.
Implementing a clinical-educator curriculum to enrich internal medicine residents' teaching capacity
Authors: Habboush Yacob , Stoner Alexis , Torres Claribel , Beidas Sary
Published: November 2019

Introduction Physicians-in-training (residents) are typically the primary educators for medical students during clinical clerkships. However, residents are not formally trained to teach or to assess their teaching. The aim of this study was to assess the implementation of a clinical educator rotation aimed at developing residents’ competencies related to clinical teaching. Methods A mixed-methods approach was used to develop and assess the clinical educator rotation at a teaching community hospital. Internal medicine residents who participated in the rotation and consented to the research were assigned to the clinical educator trainee (CET) group, the remaining residents were assigned to the control group. Osteopathic medical students rotating in the medicine service line were invited to participate. The study used descriptive and qualitative analyses to measure primary and secondary outcomes. Results The primary outcome measure showed a positive change in resident knowledge, skills and behaviors in communication, reflection, feedback, precepting, and facilitation. Medical student perceptions of resident teaching skills confirmed the observed changes in CETs. Some CETs continued to practice and build their capacity for teaching after completing the rotation. Qualitatively, we derived four common themes among the data; communication, professional engagement, practice-based learning, and systems-based learning. Conclusion Resident teaching capacity was enriched after completing the clinical educator rotation. Other benefits included: enhanced patient communication and education, increased resident confidence, personal satisfaction with training, work life-balance and enhanced career satisfaction. Future research should focus on curricular content, faculty development, and delivery assessment. In addition, research efforts should identify appropriate emerging technologies to include in the curriculum for enhancing teaching capacity.
Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study
Authors: Sato Ryuhei , Handa Tomohiro , Matsumoto Hisako , Kubo Takeshi , Hirai Toyohiro
Published: November 2019

Background: The intensity and frequency of cough remain unclear in interstitial lung disease (ILD). The aim of this study was to evaluate the intensity and frequency of cough in idiopathic interstitial pneumonias (IIPs), connective tissue disease-associated interstitial lung disease (CTD-ILD), and chronic hypersensitivity pneumonia (CHP), and examine their associations with clinical indices. Methods: In this cross-sectional study, the intensity and frequency of cough were evaluated using a 100-mm visual analogue scale. Scores on the Leicester Cough Questionnaire, chronic dyspnoea scale, and a frequency scale for symptoms of gastro-oesophageal reflux disease (FSSG) were collected. The correlations of cough intensity and frequency with potential predictor variables were tested using bivariate and multiple logistic regression analysis. Results: The study included 70 patients with IIPs, 49 with CTD-ILD, and 10 with CHP. Patients with IIPs had the most severe cough intensity among the three patient groups. In patients with IIPs, both the intensity and frequency of cough were negatively associated with the diffusing capacity of the lung for carbon monoxide and positively with the Composite Physiologic Index (CPI). In CTD-ILD, both the intensity and frequency of cough were correlated with a higher FSSG score. In multivariate analysis of patients with ILD, IIPs and the FSSG score were independently associated with both components of cough, and CPI tended to be independently associated with cough frequency. Finally, we examined the features of the differences between cough intensity and frequency in all patients with ILD. Patients in whom cough frequency was predominant had a greater impairment of health status relative to other patients. Conclusions: Cough intensity was greater in IIPs than in other ILDs. Different clinical indices were associated with patient-reported cough intensity and frequency according to the subtype of ILD. Cough frequency was more strongly associated with health status than was cough intensity. These findings suggest that medical staff could manage patients with ILD by considering cough-related factors when assessing the intensity and frequency of cough.
MicroRNA Expression Profiles Analysis in Sperm Reveals hsa-mir-191 is an Auspicious Omen of in Vitro Fertilization
Authors: Xu Hua , Wang Xin , Wang Zhikai , Li Jianhui , Xu Zhiming , Miao Maohua , Chen Guowu , Lei Xiangdong , Wu Jun , Shi Huijuan , Wang Ke , Zhang Tiancheng , Sun Xiaoxi
Published: November 2019

Background: MicroRNAs (miRNAs) are a class of noncoding small RNAs that play important roles in many physiological processes by regulating gene expression. Previous studies have shown that the expression levels of total miRNAs increase during mouse embryonic development, and some miRNAs control the regulatory network in development progression. However, few studies have focused on the effects of miRNAs on early human embryonic development. The relationship between miRNAs and early human embryogenesis is still unknown. Results:In this study, RNA-seq data collected from sperm samples from 102 patients with a normal sperm index but treated with assisted reproductive technology (ART) were analyzed for the relationships between differentially expressed small RNAs and the fertilization rate (FR), blastocyst rate and high-quality embryo rate (HQER). The sperm samples with high hsa-mir-191 expression had a higher FR, effective embryo rate (EER) and HQER. hsa-mir-191 was used as a single indicator to predict the HQER. The receiver operating characteristic (ROC) curve had an area under the ROC curve (AUC) of 0.686. We also found that hsa-mir-191 expression is correlated with an abnormal sperm rate (cor = 0.29, p< 0.01). We also evaluated the relationship between hsa-mir-34c and early human embryo development in these 102 sperm samples and obtained negative results. Conclusions: These findings suggest that high hsa-mir-191-5p expression in sperm is associated with early human embryonic quality and that hsa-mir-191-5p could be used as a potential marker to screen high-quality sperm to improve the success rates of in vitro fertilization (IVF).
Gene expression profiling identifies pathways involved in seed maturation of Jatropha curcas
Authors: Maghuly Fatemeh , Deak Tamas , Vierlinger Klemens , Pabinger Stephan , Tafer Hakim , Laimer Margit
Published: November 2019

Background: Jatropha curcas, a tropical shrub, is a promising biofuel crop, which produces seeds with high content of oil and protein. To better understand the maturation process of J. curcas seeds and to improve its agronomic performance, a two-step approach was performed in six different maturation stages of seeds: 1) generation of the entire transcriptome of J. curcas seeds using 454-Roche sequencing of a cDNA library, 2) comparison of transcriptional expression levels using a custom Agilent 8x60K oligonucleotide microarray.
Results: A total of 793,875 high-quality reads were assembled into 19,841 unique full-length contigs, of which 13,705 could be annotated with Gene Ontology (GO) terms. Microarray data analysis identified 9,111 probes (out of 57,842 probes), which were differentially expressed between the six maturation stages. The expression results were validated for 75 selected transcripts based on expression levels, predicted function, pathway, and length.
Result from cluster analyses showed that transcripts associated with fatty acid, flavonoid, and phenylpropanoid biosynthesis were over-represented in the early stages, while those of lipid storage were over-represented in the late stages. Expression analyses of different maturation stages of J. curcas seed showed that most changes in transcript abundance occurred between the two last stages, suggesting that the timing of metabolic pathways during seed maturation in J. curcas occurs in late stages. The co-expression results showed that the hubs (CB5-D, CDR1, TT8, DFR, HVA22) with the highest number of edges, associated with fatty acid and flavonoid biosynthesis, are showing a decrease in their expression during seed maturation. Furthermore, seed development and hormone pathways are significantly well connected.
Conclusion: The obtained results revealed differentially expressed sequences (DESs) regulating important pathways related to seed maturation, which could contribute to the understanding of the complex regulatory network during seed maturation with the focus on lipid, flavonoid and phenylpropanoid biosynthesis. This study provides detailed information on transcriptional changes during J. curcas seed maturation and provides a starting point for a genomic survey of seed quality traits. The results highlighted specific genes and processes relevant to the molecular mechanisms involved in Jatropha seed maturation. These data can also be utilized regarding other Euphorbiaceae species.
Plasma volume expansion across healthy pregnancy: a systematic review and meta-analysis of longitudinal studies
Authors: Aguree Sixtus , Gernand Alison D.
Published: November 2019

Background: Plasma volume expansion is an important physiologic change across gestation. High or low expansion has been related to adverse pregnancy outcomes, yet there is a limited understanding of normal/healthy plasma volume expansion. We aimed to evaluate the pattern of plasma volume expansion across healthy pregnancies from longitudinal studies. Methods: We conducted a systematic review and meta-analysis to identify original studies that measured plasma volume in singleton pregnancies of healthy women. Specifically, we included studies that measured plasma volume at least two times across gestation and one time before or after pregnancy in the same women. PubMed, Web of Science, Cochrane, CINAHL, and clinicaltrials.gov databases were searched from the beginning of each database to February 2019. We combined data across studies using a random effects model. Results: Ten observational studies with a total of 347 pregnancies were eligible. Plasma volume increased by 6% (95% CI 3-9) in the first trimester compared to the non-pregnant state. In the second trimester, plasma volume was increased by 18% (95% CI 12-24) in gestational weeks 14-20 and 29% (95% CI 21-36) in weeks 21-27 above the nonpregnant state. In the third trimester, plasma volume was increased by 42% (95% CI 38-46) in weeks 28-34 and 48% (95% CI 44-51) in weeks 35-38. The highest rate of increase occurred in the first half of the second trimester. Included studies were rated from moderate to high quality; 7 out of 10 studies were conducted over 30 years ago. Conclusions: In healthy pregnancies, plasma volume begins to expand in the first trimester, has the steepest rate of increase in the second trimester, and peaks late in the third trimester. The patterns observed from these studies may not reflect the current population, partly due to the changes in BMI over the last several decades. Additional longitudinal studies are needed to better characterize the range of normal plasma volume expansion across maternal characteristics.
Association of Cleft Lip and Palate on Mother-to-Infant Bonding: a Cross-Sectional Study in the Japan Environment and Children's Study (JECS).
Authors: Tsuchiya Shinobu , Tsuchiya Masahiro , Momma Haruki , Koseki Takeyoshi , Igarashi Kaoru , Nagatomi Ryoichi , Arima Takahiro , Yaegashi Nobuo
Published: November 2019

Background: Cleft lip and/or palate is among the most prevalent congenital birth defects, and negatively affects maternal psychological status and may consequently result in higher prevalence of child maltreatment. However, the association of childbirths of infants with cleft lip and/or palate with maternal emotional involvement still remains unclear. We examined the association between childbirths of infants with cleft lip and/or palate and mother-to-infant bonding, using data from the Japan Environment and Children's Study, a nationwide birth cohort study.
Methods: A cross-sectional study using the jecs-an-20180131 dataset was performed. A total 104,065 fetuses in 15 regional centres in Japan were enrolled after obtaining informed written consent. The Mother-to-Infant Bonding Scale, a self-report scale consisting of 10 items, was used to evaluate maternal bonding at one year after childbirth. Finally, the participants consisted of 79,140 mother-infant pairs, of which 211 mothers of infants with cleft lip and/or palate were included in our analyses. Multivariable logistic regression analysis using multiple imputation for missing data was performed to calculate the odds ratio and 95% confidence interval in the estimation of the association between bonding disorders and childbirths with cleft lip and/or palate.
Results: No increased risk of bonding disorders was observed among all the mothers of infants with cleft lip and/or palate (odds ratio [95% confidence interval]; 0.97 [0.63-1.48], p = 0.880), however, advanced maternal age or multiple parity may adversely affect the associations between bonding disorders and cleft lip and/or palate, respectively. After stratification with a combination of maternal age and parity, a significant association of cleft lip and/or palate with bonding disorders was found only among advanced-age multiparae (odds ratio [95% confidence interval] = 2.51 [1.17-5.37], p = 0.018), but it was weakened after additional adjustment for maternal depression.
Conclusions: Childbirths of infants with cleft lip and/or palate may increase the risk of bonding disorders among advanced-age multiparae, possibly through maternal depression. This finding provides valuable information for the provision of multidisciplinary cleft care.
Pregnancy outcomes among 31 patients with tetralogy of Fallot
Authors: Wang Kana , Xin Junguo , Wang Xiaodong , Yu Haiyan , Liu Xinghui
Published: November 2019

Background Ttralogy of Fallot (TOF) is a severe type of congenital heart disease (CHD) and confers substantial risk to mother and fetus. However, the outcomes of pregnant women with TOF have not been well studied. Methods Women with TOF who has been seen and/or delivered at our tertiary-care hospital between April 2008 and January 2018 were retrospective reviewed. Results A total of 31 TOF patients with pregnancies were identified in ten-year period. Among these patients, cardiac defects were surgically repaired in 19 cases and remained uncorrected in 12 women. The frequency of miscarriages and preterm birth was greater in the uncorrected group (16.67% vs one, and 50% vs 5.26%, respectively). The percentage of babies who were small for gestational age (SGA) was 41.67% and 10.53% in two groups. The neonatal mortality and fetal mortality were observed in women without correction for TOF, which were 3.23% (1/31) and 6.45(2/31), respectively. Maternal and neonatal risk appeared to be associated with heart functional classifications, pulmonary hypertension and histories of cardiac events such as serious cardiac arrhythmias. Conclusions Obstetric and cardiac complications are more frequently present in the pregnant women with uncorrected TOF. Surgical correction is associated with improved maternal and perinatal outcome.