bluuebunny/crossref_metadata_2025 huggingface dataset:
Models of Intermediate Care Organization and Staffing at an Academic Medical Center: Considerations of an Inpatient Planning Committee
Authors: Hager David N. , Dezube Rebecca , Disney Sarah M. , Flanagan Eleni , Huang Shanshan , Kakadiya Kinjal , Langlotz Ronald , Lautzenheiser Matthew B , Street Lara , Michalek Andrew , Biddison Lee D. , Desai Sanjay V. , Herzke Carrie A.
Published: January 2022

Rationale: Geographic co-localization of patients and provider teams (geography) may improve care efficiency and quality. Patients requiring intermediate care present a unique challenge to the geographic model. Objective: Identify the best organizational and staffing model for intermediate care at our academic medical center. Methods: A modified nominal group technique was employed to assess the benefits and limitations of an existing model of intermediate care, identify and review potential alternative models, and choose a new model. Results: In addition to the institution's current model, the benefits and limitations of six alternative organizational and staffing models were characterized. The anticipated impact of each model on nurse: provider communication, maintenance of nursing competencies, nurse satisfaction, efficient utilization of technical and human resources, triage of patients to the unit, care continuity, and the impact on trainee education are described. After considering these features, stakeholders ranked a closed provider staffing model on a unit dedicated to intermediate care highest of the six alternative models. Important outcomes to monitor following transition to a closed staffing model included patient outcomes, nursing job satisfaction and retention, provider and trainee experience, unexpected patient transfers to higher or lower levels of care, and administrative costs. Conclusions: After considering six alternative staffing models for intermediate care, stakeholders ranked a closed provider staffing model highest. Further qualitative and quantitative comparisons to determine optimal models of intermediate care are needed.
Virtual Guest Speakers in Textile and Apparel Courses: Student Experiences and Expectations
Authors: Jablon-Roberts Sara , McCracken Arienne
Published: January 2022

This paper focuses on the findings related to the second part of a continuing study of student impressions of the industry guest speaker experience in college fashion courses: student perceptions of virtual guest speakers. Data from 130 participants who were enrolled in the researchers’ textile and apparel classes at two United States universities were analyzed. Findings suggested that although there are disadvantages to the use of virtual industry guest visits, many students find them useful and enlightening. While respondents overall preferred in-person visits, student concern with technological issues seems to have lessened during the forced move to online coursework during the COVID-19 pandemic, and they have come to realize that the online medium, especially through the “chat” functionality found in videoconferencing platforms, can be an effective way to ask questions. Suggestions are made for instructors considering the use of the virtual medium for industry speaker visits.
Holistic Health of Two Spirit People in Canada: A Call for Nursing Action
Authors: Dykhuizen Melissa , Marshall Kerry , Loewen Walker Rachel , Saddleback Jack
Published: January 2022

Purpose: In response to item 7.1 from the Missing and Murdered Indigenous Women and Girls Report (2019), calling on health service providers to recognize the importance in inclusive services with and for Indigenous peoples including Two Spirit, lesbian, bisexual, transgender, queer, questioning, intersex, and asexual (2SLGBTQQIA) peoples, we undertook a review of the literature to identify the gaps in understanding and to better situate the health and resiliencies of Two Spirit people in Canada. Method: We conducted a review of 13 articles related to the health and wellness of the Canadian Two Spirit community. Overall, there was a dearth of Two Spirit specific health-related information. Results: Identified themes were grounded in the holistic Medicine Wheel teachings. These themes directly parallel holistic nursing in their demonstration that health is complex, and that there are many facets that make up an individuals’ health. Conclusion: Assessing the impact that colonization has had on the intersections of gender, race, sexuality, class, culture, and spirituality, Two Spirit people face unique health concerns. Considering the intersections of identity and structural barriers in place for this community, more research led by and in collaboration with the Two Spirit community is needed.
Friction stir welding of dissimilar alloy combinations—A Review
Authors: ShivaKumar G N , Rajamurugan G
Published: January 2022

Friction stir welding (FSW) is one among solid-state welding processes that can be employed for producing joints between dissimilar combinations with more ease than that of fusion welding processes. Several high coupled physical phenomena have addressed FSW as an extremely complex process. It is around three decades of invention, optimization of the parameters have been carried out even today by many researchers all over the world to obtain sound joints. This article focuses mainly on the research developments in the dissimilar FSW (DFSW), with the factors that are involved in joint fabrication between dissimilar materials. From the literature, it is found that the most influential factors in deciding the quality of the joints are pin profile, shoulder shape, welding speed and tool rotational speed. In addition, all other parameters will provide incremental support to it. The study on microstructure in different zones and the mechanical properties of welded specimens are elaborated from the available literature. Special attention is given to the reinforcement of micro- and nano- sized solid particles in the DFSW process. Future studies of DFSW are discussed based on the untracked studies that are not available in the literature.
Exploring Casting Defects of AA7075 Alloy in the Gravity Die Casting Simulation of an IC Engine Block
Authors: Aneesh T. , Pawan K. , Mohan L. , Hari Krishna P. , Hotta Tapano Kumar , Mohanty Chinmaya Prasad , Gupta Manoj
Published: January 2022

The present work aims to investigate the different casting defects that arose during the gravity die casting process of an IC engine block made of AA 7075 alloy and also highlights the feasible solutions to eradicate those defects. The minimization of the casting defects is a very crucial task in an IC engine block. Experimental studies which are generally performed to reduce the casting defects are proven to be strenuous, costly, and time-consuming. To counter this, a thermal simulation model is proposed in the present study to identify the effect of the pouring temperature, mould temperature, and the number of chillers on the various casting defects such as cold shuts, air entrapment, mould erosion, and microporosity. A detailed parametric study is conducted on the proposed model to evaluate the outcomes of important process variables on the resulting casting defects. The simulation results predict, at pouring temperature of 963 K, mould temperature of 293.15 K and with the use of 2 chillers defect-free IC engine blocks can be casted. The optimum result obtained by the proposed model is validated by conducting a confirmative test predicting an average error of 6.98%. The proposed model is effective enough in getting rid of the numerous casting defects which cannot be identified using the traditional methods; thus increasing productivity. This can be used as an economical time-saving substitute to the experimental methods during casting of various engine parts.
A comprehensive review on wire EDM performance evaluation
Authors: Alam Md Nadeem , Siddiquee Arshad Noor , Khan Zahid A , Khan Noor Zaman
Published: January 2022

Wire electric discharge machining (WEDM) technique is a fast-growing, advanced manufacturing process which is used for machining of hard materials including various alloys of steel, nickel, tungsten, cubic boron nitride, metal matrix composites (MMC's), superalloys, and ceramic materials. Moreover, it is employed for machining complex profiles and micromachining of hardened materials which are not feasible by various conventional machining processes. Generally, this process is employed to machine electrically conductive materials but during this scenario, it is also being used for machining of electrically low conducting and non-conducting ceramics including silicon carbide, aluminium oxide, silicon nitrate, and zirconium oxide ceramics by modifying the WEDM method with assisted electrode technique or forming composite of conductive and non-conductive materials. This paper presents a comprehensive review on the influence of several WEDM control factors including pulse-on time, pulse-off time, wire feed rate, peak current, wire tension, type of wire (tool) materials, types of base materials and types of powder mixed dielectric fluids on the output responses such as surface roughness (Ra), material removal rate (MRR), width of cut (kerf), wire wear ratio (WWR), wire breakage, microstructural defects, recast layer thickness, and thermal deformation. Moreover, various simulation methods, post processing methods and optimization of WEDM parameters using various techniques were discussed and at last this paper shapes the important recommendations and upcoming developments in WEDM.
Community perspectives on natural gas management in Tanzania
Authors: Bishoge Obadia Kyetuza , Kombe Godlisten Gladstone , Mvile Benatus Norbert
Published: January 2022

Several studies have discussed community participation in socio-economic projects. The studies have shown that many projects that have been initiated by either the government or private sectors have encountered resistance and reluctance from the local communities and other officials due to lack of prior and continuous involvements, poor dissemination of information on the significance of the projects, and differences in priority and interests. One of the key factors for the success and sustainability of any project is a clear understanding of the community's voluntary involvement, perspectives, and expectations of the given project. This study, therefore, aims to analyze the communities’ perspectives, expectations, and concerns related to the recent discovery and management of natural gas in Tanzania. The study adopted a questionnaire survey. Data was collected from the 115 respondents from local communities of Lindi and Mtwara regions in Tanzania. The study revealed that the communities are aware of the natural gas discoveries and policies and laws related to them. It shows that a small number of employment opportunities have been created and/or are expected to increase in the future. There should be transparency and accountability in the natural gas development, contracts, and agreements. The parliament should be the most trustworthy custodian of natural gas revenues. The study revealed that the natural gas sector would enhance the living conditions of Tanzanian households and support the attainment of the country's socio-economic development.
A Strange Sadness: Margaret Baxter on the Trauma of Conversion
Authors: Shannon Nathan
Published: January 2022

This article seeks to recover a familiar but unappreciated female voice from English Puritanism of the seventeenth century, that of Margaret Baxter. Various challenges to such recovery are examined, most notably the nature of her relationship to her pastor and husband, Richard. Extant literature from Margaret’s hand focuses on the events surrounding her conversion and life-threatening illness shortly thereafter. The present analysis of these texts and their circumstances concludes that Margaret was a faithful but critical heir of the practical theology of her day, and that in her lived expression of that tradition one observes the enduring scars of the trauma of her conversion.
My Grandmothers Baked Cakes for the Queen of Heaven: A Journey from Judaism to Goddess Spirituality
Authors: daCosta Jacqueline
Published: January 2022

In this article, I trace my story from Jewish ‘war baby’ to thealogian embracing Goddess talk; a search for spirituality, as well as for roots. I explore, in particular, Asherah, whom I accept as the Hebrew Goddess, and I share some of the insights of academics who illuminated my path. I also touch on the latest DNA evidence for the origins of Ashkenazi Jewry and my own search for identity.
‘Mass Anywhere on Sea or Land’: Catholicism and the Royal Navy, 1901–1906
Authors: Seligmann Matthew S.
Published: January 2022

Before the First World War, the law stated that only Anglican clergy could perform religious services aboard British warships; clergy of other denominations were, other than in exceptional circumstances, barred from undertaking this role. For a brief period at the start of the twentieth century an informal and unpublicized attempt was made to circumvent this requirement and provide Catholic sailors with access to their own priests at sea. The reasons for this policy, how it operated and why it ended are explored in this article.
Can Equity be Safe-haven for Investment?
Authors: Janani Sri S.  , Kayal Parthajit , Balasubramanian G.
Published: January 2022

Popular investment choices such as fixed income, gold, and real estate have generated low returns over long horizons. Equity seems to have performed much better despite its inherent risk. Although, investors prefer safe-haven assets, they are increasingly moving to equities in search for better returns. We consider whether equity could be a safe-haven investment if chosen from quality stocks’ basket. We examine the safe-haven and hedging properties of the Nifty-50 constituent stocks over the period 2008–2020. To address this, we employ copula-based framework to model the dependence structure between stocks and five indices. We distinguish between safe-haven attributes and hedging features of the individual stocks. We show that the safe-haven properties of the Nifty-50 listed stocks are not as concentrated as gold but they show much low co-movement with the market. We call them pseudo–safe-haven as they are the safe-bets for investors seeking relatively safe-haven assets with impressive returns.

JEL Codes: G11, G12, G15
High Technology Trade and the Roles of Absorptive Capabilities in Malaysia
Authors: Lam Leonard Fong Litt , Law Siong Hook , Azman-Saini W. N. W. , Ismail Normaz Wana
Published: January 2022

This article analyses the importance of high-technology trade as a channel of economic growth to ease Malaysia out of the middle-income trap. This study also wonders upon the missing absorptive capabilities that validate the likelihoods of dismal gross domestic product (GDP) growth since the 1990s. Using the autoregressive distributed lag (ARDL) approach and fully modified ordinary least squares (FMOLS) estimator as robustness checks, this study identifies the determinants of high-technology trade and the appropriate absorptive capability in enhancing economic growth. The empirical results from quarterly data from 1990 to 2015 proved that foreign direct investment, financial development and infrastructure are vital to develop a successful high-technology trade. Another important finding is that it validates the presence of trade openness (as absorptive capability) in order to magnify the benefits of research and development (R&D). This explains why, despite spending on R&D, these spending do not project to economic growth.
Experiencing the SARS-CoV-2 Pandemic Whilst Living With Cancer
Authors: Page Alexander , Broom Alex , Kenny Katherine , Lwin Zarnie , Wakefield Claire E , Itchins Malinda , Khasraw Mustafa
Published: January 2022

The SARS-CoV-2 pandemic has resulted in considerable consequences for many cancer patients, exacerbating pre-existing systemic health system limitations as well as creating new challenges. From socially distanced clinics and the widespread introduction of telehealth, to the halting of clinical trials and the reassessment of what constitutes “essential” treatment, care in oncology has abruptly changed. There is currently limited analysis of cancer patients’ experiences of the pandemic and its impacts on illness, wellness, and everyday life. Through semi-structured interviews with 54 people living with cancer during the 2020 phase of the SARS-CoV-2 pandemic in Australia, we explore how patients experience illness and care in reflecting upon a range of pandemic challenges, including delay, distance, and vulnerability. We find that in some cases, these pandemic conditions redefined the meaning of essential cancer care, reconfigured expectations around clinical trials, constructed new affective distances, and amplified dread and fear for people living with cancer.
Surgical Repositioning of the Premaxilla: Incidence, Indications and Growth Study About a 189 Bilateral Cleft Lip ± Palate Population
Authors: Drilleaud Adrien , Corre Pierre , Perrin Jean-Philippe , Loin Justine , Durand Thomas , Salagnac Jean-Michel , Delaire Jean , Mercier Jacques-Marie , Bertin Helios
Published: January 2022

Objective

We aimed to evaluate the rate of patient requiring Surgical Repositioning of the Premaxilla in a population carrying BCL  ±  P, retrieve age and operative indication. Our secondary objective was to present further facial growth characteristics.

Settings

This was a retrospective, single-center cohort study conducted in Nantes University Hospital, Oral and Maxillofacial Surgery department, tertiary cleft center.

Patients

Patients with BCL  ±  P born between 1980 and 2019 treated at Nantes University Hospital were included.

Main outcome measure

Our primary outcome measure was the rate of patient requiring SRP.

Results

Over the whole period, 189 patients with BCL  ±  P were identified. Three patients (1,58%) underwent SRP. Patients who underwent SRP all had BCLP. SRP was performed during their primary dentition period. The indication for surgical repositioning was always premaxilla vertical overgrowth with an overbite over 10 mm. Facial growth features in the three patients were mostly comparable with a population carrying BCLP who had no premaxillary surgery.

Conclusion

Our results showed a low incidence of SRP. No SRP was necessary during early infancy (ie, before lip repair) or during adulthood. Surgical repositioning of the premaxilla is beneficial for patient with orthodontically uncorrectable vertical premaxillary excess, even more since facial development compared with other patients with BCLP appears comparable.
A Clinical Report of the Complete Nasal Agenesis: Reconstruction of Congenital Arhinia and Review of the Literature
Authors: Boynuyogun Etkin , Tuncbilek Gokhan
Published: January 2022

Congenital absence of the nose or arhinia is an exceptionally rare craniofacial malformation, and the pathophysiology of the arhinia is still unknown. Most arhinia patients can have difficulties with breathing and feeding due to the absence of the nose, nasal cavities, and associated problems. A 38-day-old female patient was referred to our clinic with arhinia. Physical examination revealed the complete agenesis of nasal structures as the nasal bones and vestibulum nasi. The region of the absent nose was flat and firm at palpation. Congenital arhinia may occur with other associated malformations such as ocular, ear, palate, and gonadal. Therefore, it is recommended to evaluate computed tomography/magnetic resonance imaging in the postnatal period. Additionally, a radiological evaluation will help nasal reconstruction by documenting changes in nasal and maxillary anatomy over time. Due to the limited number of arhinia cases presented, the surgical management of this condition has not been standardized. We presented the pyramid-shaped cartilage grafts for the nasal framework and an expanded paramedian forehead flap for the skin coverage for reconstruction of arhinia.
The Case of Donald Trump and the Goldwater Rule: Politics and Professional Ethics Intertwined
Authors: Piccorelli Justin T. , Cawley R. McGreggor
Published: January 2022

In 1964, after a group of psychiatrists questioned Barry Goldwater’s mental health during the presidential campaign, the Goldwater rule became part of American Psychiatric Association’s medical ethics. The events surrounding the Goldwater rule indicate changes in the practice of psychiatry, but also politics. More recently, thirty-seven psychiatrists were compelled to question the mental health of President Donald Trump believing their greatest responsibility is to the well-being of the citizenry. These psychiatrists point to the intertwining of politics and professional ethics, a relationship, which our paper attempts to better understand.
“Good-Bye to Nonviolence?”
Authors: Scheuerman William E.
Published: January 2022

John Rawls and other liberals from the 1960s and ’70s are usually interpreted as having refurbished the idea of nonviolent civil disobedience, as practiced by Gandhi, King, and many others. That standard reading has recently provided a launching pad for a growing body of critical theoretical reflection that challenges strictly nonviolent civil disobedience’s privileged normative status. Here I offer a revisionist account of both liberal (and especially) Rawlsian nonviolent disobedience and recent attempts to supersede it. Recent critics occasionally miss their targets: the main differences separating Rawls from the critics revolve around competing empirical assessments of contemporary liberal societies and rival accounts of political violence. Rawls and other liberals, in fact, provided normative space for limited forms of “violent” lawbreaking, when resulting typically not in injuries to other persons but perhaps damage to property. The debate about nonviolent vs. violent political illegality needs to pay closer attention to the difficult issue of how best to understand and define political violence. Although we may need to provide normative space under unjust conditions for limited types of violence (e.g., property damage), substantial grounds remain for principally favoring lawbreaking that avoids injuring or violating persons.
The Correlation Between MDR1 Gene Polymorphism and Clopidogrel Resistance in People of the Hui and Han Nationalities
Authors: Zhang Jing , Dong Zhi-Feng , Bian Cheng-Xue , Zhang Xuan , Xin Xiang-Bin , Chen Fang
Published: January 2022

To investigate the differences in the correlation between multidrug resistance protein 1 ( MDR1) ( ABCB1) gene polymorphism and clopidogrel resistance in patients of the Hui and Han nationalities with percutaneous coronary intervention (PCI). A total of 377 subjects (154 people of Hui nationality, 223 people of Han nationality) with PCI were enrolled in the study. Each patient's platelet aggregation rate was induced by adenosine diphosphate and measured using light turbidimetry. Based on the results, the patients were divided into two groups: a clopidogrel resistance (CR) group and a non-clopidogrel resistance (NCR) group. Restrictive fragment-length polymorphism polymerase chain reaction technology was then used to determine the genotype and alleles at two loci (C3435 T[rs1045642] and C1236 T[rs1128503]), calculate the frequencies of the genotype and alleles at these two loci, and conduct correlation analysis. The incidence rate of clopidogrel resistance was 23.4%, and the frequencies of the TT genotype and T allele at C3435 T for patients of both nationalities were significantly higher in the CR group than in the NCR group (P < 0.05). There were no significant differences between the two groups in genotype or allele frequency at C1236 T. There was a significant difference in the distribution of C1236 T polymorphism between the two nationalities (P < 0.05), but there was no significant difference between the two nationalities in C3435 T polymorphism. Patients with a T allele at MDR1 C3435 T are more likely to show clopidogrel resistance, and no significant differences were identified in C3435 T gene polymorphism between the two nationalities.
Physicochemical stability of PF-05280014 (trastuzumab-qyyp; TrazimeraTM), a trastuzumab biosimilar, under extended in-use conditions
Authors: Weiser Sarah , Burns Christopher , Zartler Edward R.
Published: January 2022

Introduction

The stability and functional activity of the trastuzumab biosimilar PF-05280014 (trastuzumab-qyyp; TrazimeraTM), was assessed under extended in-use conditions.

Methods

PF-05280014 was diluted in 0.9% sodium chloride to final concentrations of 0.2 mg/mL and 4 mg/mL in 3 different types of infusion bags (polyolefin, ethylene vinyl acetate, and polyvinyl chloride). Infusion bags containing diluted PF-05280014 were stored at 25 ± 5° C for 24 h, before storage at 5 ± 3° C for 0, 1, 2, 4, or 6 weeks. Following extended storage, samples of PF-05280014 were removed from the infusion bags and stored at 25 ± 5° C for 24 h before biophysical and functional characterization. In addition to the visual characteristics of each sample at the various time points, the stability of PF-05280014 was assessed using a variety of biophysical techniques, including size-exclusion high-performance liquid chromatography, non-reducing sodium dodecyl sulfate capillary electrophoresis, cation-exchange chromatography, peptide mapping, far-UV circular dichroism spectroscopy, and differential scanning calorimetry. The functional activity of PF-05280014 was evaluated using a cell-based growth inhibition assay.

Results

For all PF-05280014 concentrations, time points and infusion bags tested, there were no significant differences in visual characteristics or in protein concentration. The were no significant changes in the relative abundance of molecular weight or charge variants throughout the 6-week study period. Similarly, there were no significant changes in primary structure or in secondary structure content during the study. The relative potency of PF-05280014 was also maintained throughout the 6-week period.

Conclusions

The stability and functional activity of PF-05280014 was maintained following dilution in 0.9% sodium chloride and storage for up to 6 weeks at 2–8° C.
Management of the leakage of aqueous humour caused by the wound in a cataract surgery post-operative period with Nd:YAG laser
Authors: Crespo Campello Natalia , Perucho Martínez Susana , Crespo Bordonaba Marceliano , Toledano Fernández Nicolas
Published: January 2022

Purpose

To describe a new technique for sealing aqueous leakage after cataract surgery using Nd:YAG laser.

Introduction

The leakage of aqueous humour through the corneal incisions after a surgical procedure still is one of the main complications in the cataract surgery post-operative period. Its cause depends on multiple factors, among which we find the structure of the incision. Several methods to treat its ending have been proposed over the years, and there is not a definitive and standardised method. Although most of the times they are mild and self-limited, in the cases in which the aqueous humour leakage is more profuse, a treatment is needed to avoid the risk of other complications, mainly contaminations that cause infections.

Methods

The technique consists of generating intrastromal microbubbles with the Nd:YAG laser to increase the pressure against the tunnel, achieving its sealing. It is applied on the corneal stroma, next to the incision plane. Power is set between 1.5 and 2.0 mJ (millijoules), with offset set to 0, and normally between four and six single shots would be sufficient.

Results

We have achieved the closure in all the patients that we performed this procedure so far.

Conclusions

We describe an easy and very effective technique for the sealing of the incision with an aqueous humour leakage in the immediate post-operative period of the cataract surgery by using the YAG:Nd laser, allowing a prompt and accessible treatment with a good safety profile, and reducing the need for new procedures and additional check-ups.
Exploring native-speakerism in teacher job recruitment discourse through Legitimation Code Theory: The case of the United Arab Emirates
Authors: Daoud Sumaya , Kasztalska Aleksandra
Published: January 2022

Despite growing criticisms of native-speakerism in English Language Teaching (ELT), the ‘native speaker’ concept is still used in the recruitment of teachers (Mahboob & Golden, 2013; Ruecker & Ives, 2015). This study critically evaluates the impact of native-speakerism on ELT hiring practices in the United Arab Emirates (UAE). To identify qualifications desired by employers and to document the role of the ‘native speaker’ criteria, 53 online job advertisements are analysed. The data are analysed using Legitimation Code Theory (LCT) to understand what characteristics, knowledge, and skills are discursively legitimized in the advertisements. Our results suggest that the ‘native speaker’ is indeed used as a model against which ELT applicants in the UAE are benchmarked. Because native-speakerism reflects a knower code orientation, which downplays specialized knowledge and skills, we argue that to challenge discriminatory hiring practices, employers should place more emphasis on teachers’ language proficiency and relevant knowledge and skills.
Policy gaps and opportunities: A systematic review of autism spectrum disorder and criminal justice intersections
Authors: Cooper Dylan S , Uppal Disha , Railey Kirsten S , Blank Wilson Amy , Maras Katie , Zimmerman Emily , Bornman Juan , Shea Lindsay L
Published: January 2022

Autism spectrum disorder prevalence is rising, and as this population enters adulthood, preliminary research has identified high rates of contact with the criminal justice system. Policy and programmatic reform are crucial given reported negative and violent outcomes for autistic individuals when encountering the criminal justice system. Given the size and scope of the entire criminal justice system, identifying priorities and opportunities for change is critical, and must be rooted in evidence-based findings to maximize impact and scalability. This article provides a systematic review of the literature on autism spectrum disorder and criminal justice system intersections, analyzed through a convergent qualitative synthesis. As the extant literature is diverse and employs a variety of study methods, this review allows for an analysis across study types. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis structure was utilized and captured 89 total articles from six databases. Studies are grouped by the Sequential Intercept Model, which offers a framework for analyzing criminal justice system dimensions, and informs where research at the intersection of autism spectrum disorder and the criminal justice system is most prevalent. Themes were identified at each intercept and described through key study findings to articulate implications and guidance for policy, practice, and future research to promote equitable justice for autistic individuals.

Lay abstract

The number of people with autism spectrum disorder has increased, and as this population ages, research is showing high rates of contact with the criminal justice system among this group. Social and communication differences that autistic individuals experience can act as a risk factor during these interactions, as shown by public reports of negative and violent encounters between autistic individuals and the law enforcement. There is a clear need for evidence-based strategies to reduce high rates of contact and to improve outcomes when an interaction occurs. This article provides a systematic review of research on autism spectrum disorder and criminal justice system to compile this evidence base. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis structure was used to identify 89 articles after searching six databases. The Sequential Intercept Model describes the criminal justice system as different stages, or intercepts, that are connected, and the Sequential Intercept Model serves as an overall framework to organize the included articles. Articles were analyzed to identify research themes at each intercept, which offer guidance for policy and program changes that support equitable justice for autistic individuals.
Exploring potential sources of childhood trauma: A qualitative study with autistic adults and caregivers
Authors: Kerns Connor M , Lankenau Stephen , Shattuck Paul T , Robins Diana L , Newschaffer Craig J , Berkowitz Steven J
Published: January 2022

The stressors autistic individuals encounter and experience as traumatic may vary from non-autistics. We conducted a qualitative study to identify potential sources of trauma for autistic individuals and evaluate correspondence with a standard measure. We enrolled autistic adults ( N = 14) and caregivers ( N= 15) with varied adversities, levels of functioning, and socio-demographics. Participants completed standard measures of autism, traumatic exposures and stress, and qualitative interviews, which were submitted to thematic analysis. A wide range of experiences were described as traumatic. Whereas some reflected traditional traumas (e.g. maltreatment) and forms of social marginalization, others reflected conflicts between autistic characteristics and the environment (e.g. sensory trauma). All adults and caregivers described sources of trauma in interviews not captured by standardized measures. Varied stressful experiences, many not detected by a standardized measure, may have a traumatic effect on autistic individuals. Whereas some reflect commonly recognized trauma sources, others may reflect particular vulnerabilities for autistic individuals. Results have implications for assessing traumatic events and understanding their contribution to mental health inequities in the autistic population.

Lay abstract

The stressors autistic individuals encounter and experience as traumatic may vary from those not on the spectrum and typically measured. We conducted in-depth interviews with autistic adults and caregivers of children and adults on the spectrum to identify potential sources of trauma for autistic individuals and evaluate the ability of a standard trauma measure to capture those experiences. Fourteen autistic adults and 15 caregivers with varied backgrounds, clinical profiles, and histories of adversity were interviewed. Participants also completed standard measures of autism, traumatic exposures, and stress. Interviews were analyzed to record both traditional sources of trauma, for comparison with the standard measure, and distinct sources, described as traumatic only in the narratives of participants. Participants described varied experiences as traumatic. Whereas some reflected traditional traumas (e.g. maltreatment) and forms of social marginalization, others reflected conflicts between autistic characteristics and the environment (e.g. sensory trauma). All adults and most caregivers described sources of trauma in interviews not reported on the standard measure. Results have implications for assessing traumatic events in autism and for understanding their contribution to the mental health of this group.
‘Straighten Up and Fly Right’: Radical right attempts to appeal to the British LGBTQ+ community
Authors: Foster Russell David , Kirke Xander
Published: January 2022

This article explores an emerging strategy by sections of the British radical right towards the LGBTQ+ (lesbian, gay, bisexual, transgender and queer) community, who the radical right claim are existentially threatened by the alleged violent homophobia of Islam and their ostensible betrayal by ‘the left’. Consequently, parts of the radical right present themselves as the ‘true’ protectors of LGBTQ+ individuals through what we term alter-progressivism. By analysing recorded speeches, discussions and interviews by and with key British radical right figures, we demonstrate three themes: (1) the broad radical right discourse of a ‘Great Replacement’ specifically tailored towards LGBTQ+ anxieties, (2) a narrative in which the radical right portray themselves as the defenders of (some) minorities and (3) an emerging distinction between the far-right and radical right concerning LGBTQ+ rights. We conclude that these themes represent a significant rhetorical shift and reveal the flexibility of radical right narratives in an attempt to appeal to diverse communities. This represents a serious challenge, which compels social scientists to adapt their understandings of radical right ideologies, objectives and strategies.
Modifying my self: A qualitative study exploring agency, structure and identity for women seeking publicly funded plastic surgery in Australia
Authors: Foley Kristen , Dean Nicola , Musolino Connie , Long Randall , Ward Paul
Published: January 2022

Our sociological knowledge base about plastic surgery has been predominantly constructed in free market contexts, leaving uncertainties as to how sociological theory around agency, identity, and structure apply in the context of publicly funded plastic surgeries. We draw on narratives of Australian women while waiting for abdominoplasty in the public system and recounting their post-surgical realities to understand the relational, dependent and interdependent agency–structure networks in which women's bodies, affects, lives and eligibility requirements are enmeshed. We found women adopted a ‘deserving’ identity to help them claim and enact agency as they felt and navigated the layered structures that govern publicly funded abdominoplasty in Australia, and theorise how this might influence unfolding patterns of social life. We explicate the importance of locating women's lived experiences of medical (dys)function vis-à-vis the sociocultural histories of medicine, health, gender and citizenship that give rise to publicly funded healthcare.
Queer Love, Literature and Philosophy. On Reading The Argonauts
Authors: Aldrin Salskov Salla
Published: January 2022

In this article, I suggest Maggie Nelson’s The Argonauts challenges “epistemic habits” in contemporary critical thought on gender, politics, sexuality, intimacy, identity, and love. In particular, I focus on how Nelson through descriptions of queer life, love, and kinship articulates moral-existential and queer-philosophical perspectives on everyday life by bringing the “I-You” relationship to the fore of feminist and queer theoretical concerns. By reading Nelson with the philosophy of Wittgenstein, I discuss how love is related to views on language and what it means to say that one can have, as well as lack a faith in words, other people and linguistic meaning. The Argonauts, I argue, shows us the importance of acknowledging moral-existential perspectives of gender and identity and their role in I-You relations. The article raises questions of how to understand the relationship between theory, philosophy, and ordinary language in relation to cultural critique and criticism (Butler 1990; Sedgwick 2003). It also discusses love as a perspective one might take and have in life and to other people in general, not exclusively as romantic love, but as a philosophical perspective in thinking about gender, identity, politics, love, and intimacy.
Panic and stoicism: Media, PISA and the construction of truth
Authors: Crome Jennifer
Published: January 2022

In December 2019, the Organisation for Economic Co-operation and Development released the latest results of its triennial Programme for International Student Assessment (PISA) testing. What followed was a flurry of media reports in the participant countries about the 2018 PISA results that were interpretive rather than descriptive. Whilst there is a considerable body of literature describing PISA’s impact on education policies, there are fewer studies that examine how PISA data is presented to the public by the media and how this contributes to the construction of policy truths. As part of a broader study of policy landscapes in the Asia Pacific region, this paper provides a critical analysis of the mediatisation of the 2018 PISA results in Australia and Singapore. It will be demonstrated that in Australia, much of the reporting was characterised by panic, whereas in Singapore the reporting was much more measured, exhibiting a stoicism. Drawing on a corpus of articles published in Australian and Singaporean newspapers in December 2019, and informed by the work of Michel Foucault, the analysis will make visible how dominant discourses used by the media operated as regimes of truth to advance neoliberal imperatives.
Dynamic, Time-Resolved CT Angiography After EVAR: A Quantitative Approach to Accurately Characterize Aortic Endoleak Type and Identify Inflow Vessels
Authors: Berczeli Marton , Chinnadurai Ponraj , Legeza Peter , Peden Eric K. , Bavare Charudatta S. , Chang Su Min , Lumsden Alan B.
Published: January 2022

Purpose:

Our purpose was to study the accuracy of dynamic computed tomography angiography (d-CTA) in characterizing endoleak type, inflow vessels as compared with digital subtraction angiography (DSA) using qualitative and quantitative analysis.

Methods:

Between March 2019 and January 2021, all patients who underwent d-CTA imaging after EVAR were retrospectively reviewed. Two blinded independent reviewers qualitatively reviewed d-CTA and DSA images. Quantitative region of interest (ROI) analysis was performed by measuring time-resolved contrast enhancement within the aorta and endoleak lesion(s) in the aneurysm sac. Differences between time-to-peak enhancement (Δ TTP) across different ROIs were quantified.

Results:

A total of 48 patients underwent d-CTA during the study period, of whom 24 patients had abdominal EVAR and DSA imaging for comparison. Qualitative review of DSA imaging showed type I (n=4), type II (n=16), and type III (n=2) and no endoleak (n=2). In 23 of 24 patients (95.8%), d-CTA findings correlated with DSA findings for endoleak type. One patient had a type III endoleak that was demonstrated only in d-CTA (arising from defect in polymer sealing ring of Ovation stent graft) imaging. In type II endoleak cases, d-CTA identified more inflow vessels than DSA imaging (33 vs 21 vessels, p=0.010). Quantitative analysis showed mean (±SD) Δ TTP values for type I endoleak as 1.8 (±1.8) seconds, type II as 9.6 (±3.5) seconds, and for type III endoleak as 5.6 (±1.3) seconds.

Conclusion:

Dynamic CTA can accurately characterize aortic endoleak type, inflow vessels as compared with DSA imaging. Quantitative parameters such as Δ TTP enhancement can help better differentiate endoleak types and provide an objective approach to endoleak diagnosis.
Roles of BMI1 in the Initiation, Progression, and Treatment of Hepatocellular Carcinoma
Authors: Wang Ru , Fan Hengwei , Sun Ming , Lv Zhongwei , Yi Wanwan
Published: January 2022

Liver cancer has high rates of morbidity and mortality, and its treatment is a global health challenge. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancer cases. B-lymphoma Mo-MLV insertion region 1 ( BMI1) has been identified as a proto-oncogene, which contributes to the initiation and progression of many malignant tumors. BMI1 expression is upregulated in HCC, and it influences the occurrence and development of HCC by various mechanisms, such as the INK4a/ARF locus, NF-κB signaling pathway, and PTEN/PI3K/AKT signaling pathway. In addition, the expression of BMI1 is related to prognosis and recurrence of HCC. Hence, there is clear evidence that BMI1 is a novel and valid therapeutic target for HCC. Accordingly, the development of therapeutic strategies targeting BMI1 has been a focus of recent research, providing new directions for HCC treatment. This review summarizes the role of BMI1 in the occurrence and treatment of HCC, which will provide a basis for using BMI1 as a potential target for the development of therapeutic strategies for HCC.
Prognostic Significance of Platelet (PLT) and Platelet to Mean Platelet Volume (PLT/MPV) Ratio During Apatinib Second-Line or Late-Line Treatment in Advanced Esophageal Squamous Cell Carcinoma Patients
Authors: Su Rixin , Zhu Jingya , Wu Shusheng , Luo Huiqin , He Yifu
Published: January 2022

Background: Apatinib has a certain efficacy for advanced esophageal squamous cell carcinoma (ESCC). This study aimed to investigate the prognostic significance of platelet (PLT) and platelet to mean platelet volume (PLT/MPV) ratio for advanced ESCC patients with apatinib second-line or late-line treatment. Methods: A retrospective study included 80 patients with advanced ESCC who received Apatinib ≥ 2 lines targeted therapy. We collected baseline clinical characteristics and blood parameters from the patients. Kaplan–Meier plots and univariate and multivariate analysis were used to find the factors related to progression-free survival (PFS). Results: The optimal cut-off values of PLT and PLT/MPV ratio were determined by X-tile software. Kaplan–Meier analysis demonstrated that patients in the high PLT group had better PFS than those in the low PLT group (156 d vs 80 d, P <.001), and patients in the high PLT/MPV ratio group had better PFS than those in low PLT/MPV ratio group (157 d vs 85 d, P <.001). Univariate analysis revealed pretreatment PLT and PLT/MPV ratio were significantly correlated with PFS. Multivariate analysis revealed high levels of pretreatment PLT/MPV ratio was an independent predictor of longer PFS (HR: 0.257, 95% CI: 0.089-0.743, P = .012). Conclusion: High levels of baseline PLT and PLT/MPV may indicate a better prognosis in apatinib ≥ 2 lines treatment for advanced ESCC patients.
A functional polymorphism within the distal promoter of RUNX3 confers risk of colorectal cancer
Authors: Wang Huiping , Wang Jin , Li Danhua , Zhu Zhansheng , Pei Dongsheng
Published: January 2022

Background

Accumulating evidence has indicated that runt-related transcription factor 3 ( RUNX3) gene polymorphism (rs7528484) is associated with an alimentary system cancer risk. However, the role of rs7528484 in colorectal cancer is still unclear. The present study aimed to explore the association between rs7528484 and colorectal cancer susceptibility in a Chinese Han population.

Material and methods

We firstly investigated the effect of the polymorphism rs7528484 in distal promoter of RUNX3 polymorphism on colorectal cancer risk in a Chinese Han population comprising 427 colorectal cancer patients and 503 controls. We then carried out a phenotype–genotype association analysis to validate its influence on the adjacent gene RUNX3.

Results

Logistic regression analysis demonstrated that the T allele of rs7528484 was significantly associated with an increased risk for colorectal cancer occurrence in our case-control study (odds ratio = 1.33; 95% confidence interval = 1.09–1.65; P = 0.005). In stratified analysis, the susceptibility of colorectal cancer in the T allele carriers increased among the smokers, III and IV tumor stage, and at the rectum. Furthermore, the T allele was significantly correlated with lower expression of RUNX3 in vitro.

Conclusion

In summary, the current case-control and genotype–phenotype study provides convincing evidence that functional RUNX3 polymorphism (rs7528484) is related to colorectal cancer risk and is a plausible marker for the prediction of colorectal cancer.