bluuebunny/crossref_metadata_2025 huggingface dataset:
Intergenerational Conflict or Solidarity in Hong Kong? A Survey of Public Attitudes Toward Social Spending
Authors: Wu Alfred M. , Chou Kee-Lee
Published: May 2021

This study aims to investigate age-related differences in social spending preference in an Asian context, drawing on a random survey of more than 1000 adults in Hong Kong in 2013. Contrary to popular belief, older adults in Hong Kong hold a negative view toward welfare spending, especially when it is directed toward the poor population. In contrast, descriptive statistics reveal that younger people tend to support increased spending on welfare assistance. The findings in this study provide evidence that reciprocity and solidarity in intergenerational relationships are present in Hong Kong. This demonstrates the nature of shifting social values held by different generations in a dynamic and demographically pressured Asian context. Amidst rising intergenerational conflict in different contexts in Asia, this study has profound implications for policymaking.
Bochner–Riesz operators in grand lebesgue spaces
Authors: Formica Maria Rosaria , Ostrovsky Eugeny , Sirota Leonid
Published: May 2021

We provide the conditions for the boundedness of the Bochner–Riesz operator acting between two different Grand Lebesgue Spaces. Moreover we obtain a lower estimate for the constant appearing in the Lebesgue–Riesz norm estimation of the Bochner–Riesz operator and we investigate the convergence of the Bochner–Riesz approximation in Lebesgue–Riesz spaces.
Production and characterization of experimental low noise trailing edges made of cold rolled porous aluminum with special attention to the influence of cold rolling on the mechanical stability of the investigated materials
Authors: Tychsen Jörn , Rösler Joachim
Published: May 2021

In the framework of the CRC 880 “Fundamentals of high-lift for future civil air craft” methods for the reduction of aircraft noise are investigated. An important method for this noise reduction is the usage of porous material as low noise trailing edges. To improve the aeroacoustic properties of porous materials, an innovative rolling process was established by Tychsen et al. (Metals 8:598, 2018). Here, the rolling process is described as it is used as an important method for the production of samples. The influence of cold rolling on two different porous materials namely porous aluminum 80–110 (PA 80–110) and PA 120–150 is investigated. Important characteristics studied are the porosity, mechanical properties and the dependence of flow resistivity from the degree of deformation. The flow resistivity is of particular interest as the aeroacoustic performance is significantly influenced by it. The results are then compared to the findings for PA 200–250, which was investigated in Tychsen et al. (Metals 8:598, 2018). Lastly, experimental trailing edges made out of cold rolled porous aluminum with a gradient in thickness reduction are shown. The characterization of the aeroacoustic behavior is not part of this study. Reference is made to Rossignol et al. (Int J Aeroacoust 19:365–384, 2020), where trailing edges shown here are characterized aeroacoustically. The findings shown here demonstrate that different porous materials can be tailored by cold rolling without negative impact on the mechanical behavior. It is proven that the new rolling process is a versatile tool for the production of gradient porous material.
Rule-based strategies for dynamic life cycle investment
Authors: den Haan T. R. B. , Chau K. W. , van der Schans M. , Oosterlee C. W.
Published: May 2021

In this work, we consider rule-based investment strategies for managing a defined contribution pension savings scheme, under the Dutch pension fund testing model. We find that dynamic, rule-based investment strategies can outperform traditional static strategies, by which we mean that the investor may achieve the target retirement income with a higher probability or limit the shortfall when the target is not met. In comparison with dynamic programming-based strategies, the rule-based strategies have more stable asset allocations throughout time and avoid excessive transactions that may be hard to explain to an investor. We also study a combined strategy of a rule-based target with dynamic programming. A key feature of our setting is that there is no risk-free asset, instead, a matching portfolio is introduced for the investor to avoid unnecessary risk.
Personality traits and night eating syndrome in women with bulimia nervosa and binge eating disorder
Authors: Melunsky Natasha D. , Solmi Francesca , Haime Zoë , Rowe Sarah , McIntosh Virginia V. W. , Carter Janet D. , Jordan Jennifer
Published: May 2021

Purpose

Previous research suggests that eating disorders may be associated with certain personality profiles; however, there is limited research investigating associations with night eating syndrome (NES). This research suggests harm avoidance personality trait is higher in NES individuals than in the general population, however, evidence of associations with other personality traits is inconsistent. To understand which personality traits are associated with NES symptoms, the current study aimed to improve understanding of the relationship between NES symptoms and a range of personality traits, addressing limitations in the earlier literature in this area by controlling for common confounders.

Methods

Baseline data were analysed from an outpatient psychotherapy trial for 111 women with bulimia nervosa or binge eating disorder. Pre-treatment measures of personality traits (measured with the Temperament and character inventory—revised) and NES symptoms (measured with the Night eating questionnaire) were used. Regression analyses tested associations between these variables, adjusting for potential confounders, including age and ethnicity.

Results

Low cooperativeness scores were associated with greater NES symptoms in the multivariable model (mean difference: − 0.10, 95% confidence intervals: − 0.20 to − 0.01, p = 0.033). There was weak evidence of associations between both high harm avoidance and low self-directedness personality traits and greater NES symptoms.

Conclusions

This study adds to the limited research measuring associations between a range of personality traits and NES, addressing limitations of previous research. Weak evidence for an association between high harm avoidance and low self-directedness and increased NES symptoms was found. A novel association was found between low cooperativeness and greater NES symptoms. Further research is needed to validate its presence in those with and without comorbid eating disorders and to examine the relative change in NES, eating disorder symptoms and personality scores in treatments focusing on cooperativeness.

Level of evidence

Level IV (cross-sectional data from a randomised controlled trial, CTB/04/08/139).
Top-k Competitive Location Selection over Moving Objects
Authors: Liu Ping , Wang Meng , Cui Jiangtao , Li Hui
Published: May 2021

The location selection (LS) problem identifies an optimal site to place a new facility such that its influence on given objects can be maximized. With the proliferation of GPS-enabled mobile devices, LS studies have made progress for moving objects. However, the state-of-the-art LS techniques over moving objects assume the new facility has no competitor, which is too restrictive and unrealistic for real-world business. In this paper we study Competitive Location Selection over Moving objects (CLS-M), which takes into account competition against existing facilities in mobile scenarios. We present a competition-based influence score model to evaluate the influence of a candidate. To solve the problem, we propose an influence pruning algorithm to prune objects who are either influenced by inferior candidates or affected by no candidate. Experimental study over two real-world datasets demonstrates that the proposed algorithm outperforms state-of-the-art LS techniques in terms of efficiency.
Religion und ihre Einbettung in Verfassungen als Kontext
Authors: Schnabel Annette , Hönes Lisa
Published: May 2021

Soziologisch lassen sich Verfassungstexte als wichtiges Moment der Konstruktion kollektiver Identitäten und idealer Mitgliedschaften staatlicher Gemeinschaften verstehen. Auf der Basis einer quantitativen, explorativen Dokumentenanalyse von Verfassungstexten aus 186 Ländern wird untersucht, welche religionsbezogenen Identifikationsangebote Verfassungen machen. Dies wird anhand von drei Themenfeldern expliziert: (i) Präambeln leiten den Verfassungstext ein, hier findet sich die Bestimmung des „wir“ der verfassungsgebenden Gemeinschaft, indem sie den „Geist“, in dem die Verfassung verfasst ist, entfalten; (ii) Die Untersuchung der Verankerung von Religions- und Gewissensfreiheit sowie ihrer Einschränkungen in den Verfassungstexten gibt Auskunft über den Stellenwert, den Religion und Religiosität für die Verfasstheit der good citizens hat. Hieran wird auch sichtbar, welches Verhältnis staatlich verfasste Sozialitäten zur individuellen Religionsfreiheit haben. (iii) Staatliche Biopolitiken wiederum umfassen neben anderen policies auch die verfassungsmäßige Verankerung der gouvernementalen Verantwortung für die (Aus‑)Bildung der future citizens. Diese umfasst Art und Umfang der Schulpflicht ebenso wie die Verankerung religions-bezogener Curricula. Mit ihren Identitätsangeboten konfigurieren Verfassungen den good citizen und schaffen damit eine soziale Ordnung, indem Bürger*innen als Subjekte mit Rechten und Pflichten angerufen werden. Im globalen Vergleich bleibt Religion dabei wichtiges Element – sei es als Adresse der staatlichen Schutzverpflichtung individueller Freiheiten, als Moment der Bedrohung der Freiheit anderer und der staatlichen Ordnung oder als konfessionell bestimmter Bestandteil der staatlichen Gemeinschaft.
Contestations of the Liberal International Order
Authors: Söderbaum Fredrik , Spandler Kilian , Pacciardi Agnese
Published: May 2021

A seemingly never-ending stream of observers claims that the populist emphasis on nationalism, identity, and popular sovereignty undermines international collaboration and contributes to the crisis of the Liberal International Order (LIO). Why, then, do populist governments continue to engage in regional and international institutions? This Element unpacks the counter-intuitive inclination towards institutional cooperation in populist foreign policy and discusses its implications for the LIO. Straddling Western and non-Western contexts, it compares the regional cooperation strategies of populist leaders from three continents: Hungarian Prime Minister Viktor Orbán, former Venezuelan President Hugo Chávez, and Philippine President Rodrigo Duterte. The study identifies an emerging populist 'script' of regional cooperation based on notions of popular sovereignty. By embedding regional cooperation in their political strategies, populist leaders are able to contest the LIO and established international organisations without having to revert to unilateral nationalism.
Chronic traumatic encephalopathy (CTE) is absent from a European community-based aging cohort while cortical aging-related tau astrogliopathy (ARTAG) is highly prevalent
Authors: Forrest SL , Kril JJ , Wagner S , Hönigschnabl S , Reiner A , Fischer P , Kovacs GG
Published: May 2021

Chronic traumatic encephalopathy (CTE) and aging-related tau astrogliopathy (ARTAG) are characterised by tau-immunopositive neuronal and/or astrocytic inclusions, with overlapping cortical involvement and astrocytic inclusion morphology. This study determined the prevalence of CTE and cortical ARTAG in a European community-based population (n=310) and explored overlap of both pathological entities. Frontal, parietal and temporal cortices were assessed. No case fulfilling CTE criteria was found. However, isolated astroglial or neuronal tau pathologies were recognized in sulcal depths (<2%). One case without history of traumatic brain injury showed combined tau-immunoreactive features confined to frontal sulci without perivascular accumulation. Another 24 cases had single tau pathologies in cortical sulci. ARTAG was identified in 117 cases (38%), with a similar regional prevalence. Grey matter ARTAG was the most common followed by subpial, white matter and perivascular. The presence of any type of ARTAG was associated with having another type of ARTAG in the same region (P<0.05). In summary, cortical ARTAG in this population is common and contrasts the high prevalence of CTE in individuals with repeated mild traumatic brain injury.

LEARNING OBJECTIVES

This presentation will enable the learner to:

Classify tau-immunopositive astrocytic inclusions characteristic of ARTAG

1.

Describe neuropathological components of CTE

2.

Identify CTE and cortical ARTAG in a case series
The Amygdala in Neurodegeneration
Authors: Joseph JT
Published: May 2021

The amygdala is a key anatomic structure that has multiple different nuclei and is involved in several critical aspects of cognition and systemic functions. Several different neurodegenerative diseases have major pathological effects on distinct amygdala nuclei. This presentation will describe the classic and characteristic anatomic distributions in the amygdala of “pure” Alzheimer disease and “pure” Lewy body disease, as well as “normal aging”. In addition, data will be presented on how these classic distributions are altered in either “mixed dementias” or in some atypical forms of neurodegeneration. Amygdala pathology will also be illustrated in several other neurodegenerative diseases. The implications of the differing anatomic distributions in different neurodegenerative diseases will be discussed.

LEARNING OBJECTIVES

This presentation will enable the learner to:

Recognize key anatomic divisions of the amygdala

1.

Describe how different neurodegenerative diseases affect the amygdala

2.

Consider how anatomic specificity of protein aggregation is important in the classification of neurodegenerative diseases
Evaluating clinical outcomes of routinely delivered task-shared care for depression in rural Haiti
Authors: Rose Alexandra L. , McBain Ryan , Wilson Jesse , Coleman Sarah F. , Mathieu Emmanuel , Fils-Aimé J. Reginald , Affricot Emmeline , Thérosmé Tatiana , Dubuisson Wilder , Eustache Eddy , Smith Stephanie L. , Raviola Giuseppe
Published: May 2021

Background

There is a growing literature in support of the effectiveness of task-shared mental health interventions in resource-limited settings globally. However, despite evidence that effect sizes are greater in research studies than actual care, the literature is sparse on the impact of such interventions as delivered in routine care. In this paper, we examine the clinical outcomes of routine depression care in a task-shared mental health system established in rural Haiti by the international health care organization Partners In Health, in collaboration with the Haitian Ministry of Health, following the 2010 earthquake.

Methods

For patients seeking depression care betw|een January 2016 and December 2019, we conducted mixed-effects longitudinal regression to quantify the effect of depression visit dose on symptoms, incorporating interaction effects to examine the relationship between baseline severity and dose.

Results

306 patients attended 2052 visits. Each visit was associated with an average reduction of 1.11 in depression score (range 0–39), controlling for sex, age, and days in treatment (95% CI −1.478 to −0.91; p < 0.001). Patients with more severe symptoms experienced greater improvement as a function of visits (p = 0.04). Psychotherapy was provided less frequently and medication more often than expected for patients with moderate symptoms.

Conclusions

Our findings support the potential positive impact of scaling up routine mental health services in low- and middle-income countries, despite greater than expected variability in service provision, as well as the importance of understanding potential barriers and facilitators to care as they occur in resource-limited settings.
A 3.5-kW near-single-mode oscillating–amplifying integrated fiber laser
Authors: Zeng Lingfa , Wang Xiaolin , Yang Baolai , Zhang Hanwei , Xu Xiaojun
Published: May 2021

The fiber laser based on an oscillating-amplifying integrated structure has the potential to benefit from the advantages of a fiber laser oscillator and amplifier with the characteristics of strong anti-back-reflected light ability and high efficiency. Here, we achieved a 3.5-kW near-single-mode (M2 ∼ 1.24) oscillating–amplifying integrated fiber laser with an active fiber length of 8 m in the oscillating section and 17.6 m in the amplifying section. While operating at the maximum power, the optical-to-optical conversion efficiency is 87.0%, and the intensity of stimulated Raman scattering is about 23.61 dB lower than that of the signal light. To the best of the authors’ knowledge, this is the highest output power of an oscillating–amplifying integrated fiber laser, accompanied with the best beam quality and the highest efficiency.
A descriptive pilot survey of behavioural addictions in an adolescent secondary school population in Ireland
Authors: Columb David , Keegan Eoghan , Griffiths Mark D. , O’Gara Colin
Published: May 2021

Objectives:

The aim of the present study was to evaluate the levels of possible internet addiction, gaming addiction, gambling addiction and associated mental health difficulties in a secondary school population in Ireland.

Methods:

An online survey containing questions related to internet addiction, gaming addiction, gambling addiction and associated mental health difficulties was administered to secondary school adolescents in Ireland. Participants were self-selecting and answered questions on the characteristics of each topic and screening questionnaires for addiction to each behaviour, as well as their respective effects on mental health.

Results:

A total of 234 children participated in the survey (156 males; aged 12–18 years; average age of 14.2 years; S.D. 1.60). Internet addiction as assessed using the Chen Internet Addiction Scale was present for between 11.5% and 22.6% and levels of gaming addiction as assessed using by the Internet Gaming Disorder Scale–Short Form was present for between 0.5% and 1.6%. Weak positive correlations were found between time spent on the internet and time spent gaming with internet addiction and gaming addiction, respectively. There were weak positive correlations between higher internet addiction scores, higher gaming addiction scores, and increased depression and anxiety scores. Using the South Oaks Gambling Screen–Revised for Adolescents, two participants were classed as ‘at-risk’ for gambling addiction and one participant was classed as a problem gambler.

Conclusions:

The present study examined behavioural addictions and their effects on mental health on a self-selecting sample of schoolchildren at two schools in Ireland. A low number were identified as being at risk or problem gamblers.
Intensified Liminal Legality: The Impact of the DACA Rescission for Undocumented Young Adults in Colorado
Authors: Burciaga Edelina M. , Malone Aaron
Published: May 2021

The Deferred Action for Childhood Arrivals (DACA) program provides qualifying undocumented immigrant youth with significant benefits. These benefits exist in a state of tension because they are temporary, making the status of DACA recipients precarious. In this article we draw on survey and interview data collected with DACA recipients in Colorado, along with community stakeholder interviews and observations to examine the liminally legal experience of recipients, both before and after Donald Trump’s announced intention to terminate the program. Focusing on their experiences of precarity across educational, economic, and emotional spheres, we document the negative and lasting consequences that the loss of DACA status would have for them. Given the rapidly shifting legal context of the DACA program, we argue that liminal legality varies in intensity based on political context and place. While undocumented young adults are acutely aware of the uncertainty of this moment, we also show how they are demonstrating resilience in the face of increasingly harmful immigration policies. The liminal legality of DACA status, which has worsened in the recent political context, underscores the urgent need for a permanent legislative solution.
SMOOTH FANO 4-FOLDS IN GORENSTEIN FORMATS
Authors: QURESHI MUHAMMAD IMRAN
Published: May 2021

We construct some new deformation families of four-dimensional Fano manifolds of index one in some known classes of Gorenstein formats. These families have explicit descriptions in terms of equations, defining their image under the anticanonical embedding in some weighted projective space. They also have relatively smaller anticanonical degree than most other known families of smooth Fano 4-folds.
Petrogenesis and tectonic significance of the middle Neoproterozoic highly fractionated A-type granite in the South Qinling block
Authors: Qiu Xiao-Fei , Xu Qiong , Jiang Tuo , Lu Shan-Song , Zhao Long
Published: May 2021

The South Qinling block, a segment of the Yangtze craton involved in the Qinling–Dabie orogen, is critical for understanding the tectonic evolution of eastern China. However, the tectonic setting of the South Qinling block and the northern margin of the Yangtze block during middle Neoproterozoic time has long been the subject of debate, with two distinctly different models (continental rift or volcanic arc) proposed. Here, a comprehensive study of zircon U–Pb geochronology and geochemistry has been carried out on the Chengwan granitic pluton from the Suizao terrane in the South Qinling block. The granites are monzogranite and syenogranite in lithology, and are mainly composed of potash feldspar, quartz, plagioclase and biotite. This suite has long been regarded as a Palaeozoic magmatic pluton, but zircon U–Pb ages of 809 ± 9 Ma and 816 ± 4 Ma are obtained in this study. The granites are metaluminous to strongly peraluminous with high alkali contents, and exhibit highly fractionated features, including high SiO2, low Zr/Hf ratios, rare earth element tetrad effects and enrichment of K and Rb. They show Hf–Nd isotopic decoupling, which may be genetically related to their petrogenetic process. Based on the geochemical features and the positive εHf(t) values of the zircons, it is indicated that the granites may have been derived from partial melting of juvenile tonalitic rocks by biotite breakdown under fluid-absent conditions. The Chengwan granite geochemically belongs to the A2-subtype granites, suggesting that it might have formed in a post-orogenic tectonic setting. The highly fractionated A-type granite in this study may represent extensional collapse shortly after the collisional events in the South Qinling block, and thus indicate a tectonic regime switch, from compression to extension, as early as middle Neoproterozoic time. Integrating our new data with documented magmatic, metamorphic and sedimentary events during middle Neoproterozoic time in the region may support a continental rift model, and argues against arc models.
The economic corridors paradigm as extractivism: Four theses for a historical materialist framework
Authors: Thame Charlie
Published: May 2021

Economic corridors are under construction across the planet. Trillions of dollars are being spent and they will have significant implications for international politics and, ultimately, world order. However, there has been limited conceptual work on them to date, especially in International Relations. This article contributes to that gap by explaining the dominant rationale before offering a conceptualisation of economic corridors as an essentially extractivist paradigm. This counter-hegemonic proposition revolves around four relational theses: (1) economic corridors are a ‘fix’ for crises of capitalism; (2) economic corridors exacerbate class struggle; (3) economic corridors are tools for exploitation; (4) economic corridors facilitate financial extraction. In so doing it unmasks the dominant rationale as ideological cover for valorisation and accumulation based on extractive and exploitative relations with human and extra-human nature. Rather than contributing to inclusive and sustainable development as proponents claim, the article contends economic corridors reinforce power asymmetries between states, countries, and classes, thereby extending and entrenching processes of uneven and combined development. The argument is substantiated with empirical reference to mainland Southeast Asia but aims to advance understanding of extractive dynamics integral to the concept of economic corridors and hence operative worldwide.
Politics Turns Moral Foundations Into Consequences of Intergroup Attitudes
Authors: Hadarics Márton , Kende Anna
Published: May 2021

Abstract. Applying a longitudinal design, we tested the directions of the relationships between moral foundations and attitudes toward Muslim immigrants. The study was conducted during the official campaign period of the Hungarian parliamentary elections in 2018. It was found that moral foundations are consequences of intergroup attitudes. Latent change modeling showed that while individualizing foundations were independent of anti-Muslim attitudes, longitudinal change in binding foundations was predicted by prior anti-Muslim attitudes, but not the other way around. Furthermore, this relationship was moderated by exposure to the anti-Muslim and anti-immigration campaigns led by the government. These results suggest that people are motivated to harmonize their moral concerns with their prior social beliefs, and they actively utilize available political messages in this process.
Water‐Mass Properties and Circulation in the Deep and Abyssal Philippine Sea
Authors: Tian Zichen , Zhou Chun , Xiao Xin , Wang Tinghao , Qu Tangdong , Yang Qingxuan , Zhao Wei , Tian Jiwei
Published: May 2021

Water‐mass properties and circulation in the deep and abyssal Philippine Sea are investigated using repeatedly occupied full‐depth hydrographic data. The abyssal water‐mass, the Lower Circumpolar Deep Water (LCDW), is captured. After crossing the Yap Mariana Junction, the LCDW spreads to the Parece Vela Basin, the southern part of the Shikoku Basin, the Minami‐Daito Basin, and the northern Philippine Basin, with its upper interface sinking from ∼4,000 m to ∼5,000 m. Blocked by the Central Basin Fault, the LCDW cannot penetrate further southward into the southern Philippine Basin. An abyssal current across the Kyushu‐Palau Ridge connecting the eastern and western parts of the Philippine Sea is identified at 22.5°N–29.5°N, which is suggested to be the main branch transporting LCDW from the Yap Mariana Junction westward into the northern Philippine Basin. Synoptic analysis of hydrographic observations suggests the existence of a cyclonic circulation in the abyssal Philippine Sea. During 1990–2020, a warming trend of 0.33 ± 0.19 × 10−3°C yr−1 is identified at depths below 2,000 m, while a SiO2 maximum core at 30°N implies a possible cooling of the Mixed Deep Water (more influenced by North Pacific Deep Water) in the Philippine Sea. Under 4,000 m, freshening together with warming south of 20°N indicate contraction of LCDW after entering the Yap Mariana Junction.
Data‐Driven Forecasting of Low‐Latitude Ionospheric Total Electron Content Using the Random Forest and LSTM Machine Learning Methods
Authors: Zewdie Gebreab K. , Valladares Cesar , Cohen Morris B. , Lary David J. , Ramani Dhanya , Tsidu Gizaw M.
Published: May 2021

In this research, we present data‐driven forecasting of ionospheric total electron content (TEC) using the Long‐Short Term Memory (LSTM) deep recurrent neural network method. The random forest machine learning method was used to perform a regression analysis and estimate the variable importance of the input parameters. The input data are obtained from satellite and ground based measurements characterizing the solar‐terrestrial environment. We estimate the relative importance of 34 different parameters, including the solar flux, solar wind density, and speed the three components of interplanetary magnetic field, Lyman‐alpha, the Kp, Dst, and Polar Cap (PC) indices. The TEC measurements are taken with 15‐s cadence from an equatorial GPS station located at Bogota, Columbia (4.7110° N, 74.0721° W). The 2008–2017 data set, including the top five parameters estimated using the random forest, is used for training the machine learning models, and the 2018 data set is used for independent testing of the LSTM forecasting. The LSTM method as applied to forecast the TEC up to 5 h ahead, with 30‐min cadence. The results indicate that very good forecasts with low root mean square (RMS) error (high correlation) can be made in the near future and the RMS errors increase as we forecast further into the future. The data sources are satellite and ground based measurements characterizing the solar‐terrestrial environment.
Geodetic Observation and Modeling of the Coseismic and Postseismic Deformations Associated With the 2020 Mw 6.5 Monte Cristo Earthquake
Authors: Li Shuiping , Tao Tingye , Chen Yunguo , He Ping , Gao Fei , Qu Xiaochuan , Zhu Yongchao
Published: May 2021

The 2020 Mw 6.5 Monte Cristo earthquake occurred in the northeastern Mina deflection of the central Walker Lane Belt (WLB) in Nevada, USA. The Mina deflection represents a typical stepover zone that transfers the dextral slip in the northern Eastern California Shear Zone onto the dextral faults in the central WLB. The Monte Cristo earthquake provides a rare opportunity to investigate the strain accumulation and stress transition mechanisms in the WLB. In this study, ascending and descending Sentinel‐1 images were utilized to generate coseismic and early postseismic deformations associated with this earthquake. Combined with global positioning system measurements, these images were inverted for the coseismic slip and afterslip of the Monte Cristo earthquake. The preferred coseismic slip model suggests that the causative fault is characterized by two fault segments with southward dips of 64° and 79°. The coseismic rupture was dominated by sinistral slip with obvious normal slip components in the western segment of the source fault. The coseismic slip was mainly concentrated in the 3–12 km depth range and decreased at shallower depths, suggesting a moderate amount of shallow coseismic slip deficit. Rapid afterslip was mainly confined to the 0–3 km depth range, largely compensating for the shallow slip deficit caused by the mainshock. The widely distributed normal slips in the northeastern Mina deflection revealed by the Monte Cristo earthquake suggest the transtensional model is more applicable due to its ability to account for the slip transition kinematics in the Mina deflection.
The Estimation of D‐Region Electron Densities From Trans‐Ionospheric Very Low Frequency Signals
Authors: Worthington E. R. , Cohen M. B.
Published: May 2021

Due to the relatively low ionization levels present in the D‐region of the ionosphere (60–90 km), few reliable methods exist for estimating electron densities at this altitude. Very Low Frequency (VLF, 3–30 kHz) radio waves, unlike higher frequency waves used for similar remote sensing applications, are sensitive to these low ionization levels. Much past work has addressed the estimation of D‐region electron densities using ground‐based measurements of signals originating from VLF transmitters or atmospheric lightning. We introduce a new technique for the estimation of ionospheric D‐region electron densities using satellite observations of trans‐ionospheric VLF signals originating from high‐powered VLF transmitters. Although most of the energy radiated from these transmitters is confined to sub‐ionospheric propagation modes, a small fraction penetrates the ionosphere in a right‐hand circularly polarized “whistler mode” which has been observed by many satellites. We show that the modal interference pattern previously observed enables the estimation of the electron density profile in the D‐region from a single satellite pass. Using data from the DEMETER experiment, each collection is compared with results from a validated theoretical model to select a best‐fit D‐region electron density profile. Results show expected seasonal variations and are consistent with rocket observations. Although the D‐region electron density estimates derived with this technique are shown to exhibit long‐term seasonal variations consistent with rocket and ground‐based observations, it is important to note that validation of these results remains difficult due to the lack of other techniques for continuously sensing the D‐region.
Temporal Evolution of Three‐Dimensional Structures of Metal Ion Layer Around Japan Simulated by a Midlatitude Ionospheric Model
Authors: Andoh Satoshi , Saito Akinori , Shinagawa Hiroyuki
Published: May 2021

A regional numerical ionospheric model with neutral winds, corresponding to the Ground‐to‐topside model of Atmosphere and Ionosphere for Aeronomy model, was used to investigate the temporal evolution of 3‐D structures of metal ion layers (MILs) around Japan. The MILs that appear specifically in the ionospheric E region, called “sporadic E,” display complicated multi‐layer structures and intense density variations. Although the wind shear theory elucidates the basic formation mechanism of MILs, it does not fully explain the physical mechanism of 3‐D MIL structures, especially their sporadic behavior. Herein, we present two simulation cases in which the effect of the monthly mean and day‐to‐day variations of wind on the MILs around Japan was investigated. The temporal evolutions of the complicated MIL structures were classified into the following four phases: (1) Above 110 km, MILs are generally constrained vertically and horizontally at the zonal‐wind shear null. (2) Below 110 km, MILs lag behind the zonal‐wind shear null, and the 3‐D MIL structures are affected not only by the wind shears but also by the magnitude and direction of the horizontal winds. (3) When stagnating metal ions exist below a descending MIL, some metal ions ascend and merge with the descending MIL, thereby increasing its density. (4) MILs stagnate at around 100 km or descend to <100 km depending on the strength of the vertical winds. Our results reveal that Phases (2–4) are crucial for the formation of complicated MIL structures.
A Census of Eddies in the Tropical Eastern Boundary of the Indian Ocean
Authors: Azis Ismail M. F. , Ribbe J. , Arifin T. , Taofiqurohman A. , Anggoro D.
Published: May 2021

The Indo‐Australian Basin (IAB) constitutes a crucial water route for the global ocean's circulation between the Pacific and Indian Oceans. Locally generated eddies contribute to the continued westward transport of water away from the IAB. In this paper, results from the first comprehensive regional ocean eddy census are discussed. A hybrid eddy census and tracking algorithm is used to analyze satellite altimetry data from 1993 to 2018. A total of 2,792 eddies were identified and tracked. Cyclonic eddies and anticyclonic eddies exhibit geographical segregation in terms of their dynamic characteristics. Larger amplitudes, radii, and absolute vorticities are associated with high eddy kinetic energy regions located in the vicinity of the South Java Current, South Equatorial Current, and Indonesian Throughflow. The eddies are grouped into three duration‐based classifications providing the first systematic insight into understanding their physical characteristics, formation, and distribution in the IAB.
Localization-limited exciton oscillator strength in colloidal CdSe nanoplatelets revealed by the optically induced stark effect
Authors: Geiregat Pieter , Rodá Carmelita , Tanghe Ivo , Singh Shalini , Di Giacomo Alessio , Lebrun Delphine , Grimaldi Gianluca , Maes Jorick , Van Thourhout Dries , Moreels Iwan , Houtepen Arjan J. , Hens Zeger
Published: May 2021

2D materials are considered for applications that require strong light-matter interaction because of the apparently giant oscillator strength of the exciton transitions in the absorbance spectrum. Nevertheless, the effective oscillator strengths of these transitions have been scarcely reported, nor is there a consistent interpretation of the obtained values. Here, we analyse the transition dipole moment and the ensuing oscillator strength of the exciton transition in 2D CdSe nanoplatelets by means of the optically induced Stark effect (OSE). Intriguingly, we find that the exciton absorption line reacts to a high intensity optical field as a transition with an oscillator strength FStark that is 50 times smaller than expected based on the linear absorption coefficient. We propose that the pronounced exciton absorption line should be seen as the sum of multiple, low oscillator strength transitions, rather than a single high oscillator strength one, a feat we assign to strong exciton center-of-mass localization. Within the quantum mechanical description of excitons, this 50-fold difference between both oscillator strengths corresponds to the ratio between the coherence area of the exciton’s center of mass and the total area, which yields a coherence area of a mere 6.1 nm2. Since we find that the coherence area increases with reducing temperature, we conclude that thermal effects, related to lattice vibrations, contribute to exciton localization. In further support of this localization model, we show that FStark is independent of the nanoplatelet area, correctly predicts the radiative lifetime, and lines up for strongly confined quantum dot systems.
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
Authors: Zhong Lei , Li Yueshan , Xiong Liang , Wang Wenjing , Wu Ming , Yuan Ting , Yang Wei , Tian Chenyu , Miao Zhuang , Wang Tianqi , Yang Shengyong
Published: May 2021

Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs, targeted therapeutic drugs have become mainstream cancer treatments. Since the first tyrosine kinase inhibitor imatinib was approved to enter the market by the US Food and Drug Administration (FDA) in 2001, an increasing number of small-molecule targeted drugs have been developed for the treatment of malignancies. By December 2020, 89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration (NMPA) of China. Despite great progress, small-molecule targeted anti-cancer drugs still face many challenges, such as a low response rate and drug resistance. To better promote the development of targeted anti-cancer drugs, we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification. We present all the approved drugs as well as important drug candidates in clinical trials for each target, discuss the current challenges, and provide insights and perspectives for the research and development of anti-cancer drugs.
Plasma polyunsaturated fatty acids and mental disorders in adolescence and early adulthood: cross-sectional and longitudinal associations in a general population cohort
Authors: Mongan David , Healy Colm , Jones Hannah J. , Zammit Stan , Cannon Mary , Cotter David R.
Published: May 2021

Polyunsaturated fatty acids (PUFAs) may be pertinent to the development of mental disorders, for example via modulation of inflammation and synaptogenesis. We wished to examine cross-sectional and longitudinal associations between PUFAs and mental disorders in a large cohort of young people. Participants in the Avon Longitudinal Study of Parents and Children were interviewed and provided blood samples at two sampling periods when approximately 17 and 24 years old. Plasma PUFA measures (total omega-6 [n-6], total omega-3 [n-3], n-6:n-3 ratio and docosahexaenoic acid [DHA] percentage of total fatty acids) were assessed using nuclear magnetic resonance spectroscopy. Cross-sectional and longitudinal associations between standardised PUFA measures and three mental disorders (psychotic disorder, moderate/severe depressive disorder and generalised anxiety disorder [GAD]) were measured by logistic regression, adjusting for age, sex, body mass index and cigarette smoking. There was little evidence of cross-sectional associations between PUFA measures and mental disorders at age 17. At age 24, the n-6:n-3 ratio was positively associated with psychotic disorder, depressive disorder and GAD, while DHA was inversely associated with psychotic disorder. In longitudinal analyses, there was evidence of an inverse association between DHA at age 17 and incident psychotic disorder at age 24 (adjusted odds ratio 0.44, 95% confidence interval 0.22–0.87) with little such evidence for depressive disorder or GAD. There was little evidence for associations between change in PUFA measures from 17 to 24 years and incident mental disorders at 24 years. These findings provide support for associations between PUFAs and mental disorders in early adulthood, and in particular, for DHA in adolescence in relation to prevention of psychosis.
Association between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank
Authors: Weber Andrea , Leitzmann Michael F. , Sedlmeier Anja M. , Baurecht Hansjörg , Jochem Carmen , Haferkamp Sebastian , Baumeister Sebastian E.
Published: May 2021

Background

Physical activity has been positively related to malignant melanoma. However, that association may be confounded by ultraviolet radiation (UV), a variable closely related to both outdoor physical activity and malignant melanoma. We examined physical activity, grip strength and sedentary behaviour in relation to risk of malignant melanoma, accounting for relevant confounders using data from a prospective cohort study.

Methods

In 350,512 UK Biobank participants aged 38–73 years at baseline, physical activity was assessed with a modified version of the International Physical Activity Questionnaire Short Form, grip strength was measured with a hand dynamometer, and sedentary behaviour was recorded with three specific questions. Multivariable hazard ratios (HR) and corresponding 95% confidence intervals (CI) were estimated using Cox proportional hazards regression.

Results

During 7 years of follow-up, 1239 incident malignant melanoma diagnoses were recorded. Physical activity and sedentary behaviour were unrelated to malignant melanoma (HRs 1.01 (95% CI 0.95–1.07) and 1.04 (95% CI 0.97–1.12), respectively), and the initially positive association with grip strength in the basic model (HR 1.23, 95% CI 1.08–1.40) was attenuated after full adjustment (HR 1.10, 95% CI 0.96–1.26).

Conclusion

Physical activity, grip strength and sedentary behaviour are not associated with malignant melanoma risk.
High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
Authors: Deitersen Jana , Berning Lena , Stuhldreier Fabian , Ceccacci Sara , Schlütermann David , Friedrich Annabelle , Wu Wenxian , Sun Yadong , Böhler Philip , Berleth Niklas , Mendiburo María José , Seggewiß Sabine , Anand Ruchika , Reichert Andreas S. , Monti Maria Chiara , Proksch Peter , Stork Björn
Published: May 2021

Autophagy is an intracellular recycling pathway with implications for intracellular homeostasis and cell survival. Its pharmacological modulation can aid chemotherapy by sensitizing cancer cells toward approved drugs and overcoming chemoresistance. Recent translational data on autophagy modulators show promising results in reducing tumor growth and metastasis, but also reveal a need for more specific compounds and novel lead structures. Here, we searched for such autophagy-modulating compounds in a flow cytometry-based high-throughput screening of an in-house natural compound library. We successfully identified novel inducers and inhibitors of the autophagic pathway. Among these, we identified arzanol as an autophagy-modulating drug that causes the accumulation of ATG16L1-positive structures, while it also induces the accumulation of lipidated LC3. Surprisingly, we observed a reduction of the size of autophagosomes compared to the bafilomycin control and a pronounced accumulation of p62/SQSTM1 in response to arzanol treatment in HeLa cells. We, therefore, speculate that arzanol acts both as an inducer of early autophagosome biogenesis and as an inhibitor of later autophagy events. We further show that arzanol is able to sensitize RT-112 bladder cancer cells towards cisplatin (CDDP). Its anticancer activity was confirmed in monotherapy against both CDDP-sensitive and -resistant bladder cancer cells. We classified arzanol as a novel mitotoxin that induces the fragmentation of mitochondria, and we identified a series of targets for arzanol that involve proteins of the class of mitochondria-associated quinone-binding oxidoreductases. Collectively, our results suggest arzanol as a valuable tool for autophagy research and as a lead compound for drug development in cancer therapy.
Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons
Authors: Allodi Ilary , Montañana-Rosell Roser , Selvan Raghavendra , Löw Peter , Kiehn Ole
Published: May 2021

ALS is characterized by progressive inability to execute movements. Motor neurons innervating fast-twitch muscle-fibers preferentially degenerate. The reason for this differential vulnerability and its consequences on motor output is not known. Here, we uncover that fast motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression in the SOD1G93A mouse model leads to specific loss of inhibitory synapses onto fast motor neurons. Inhibitory V1 interneurons show similar innervation pattern and loss of synapses. Moreover, from postnatal day 63, there is a loss of V1 interneurons in the SOD1G93A mouse. The V1 interneuron degeneration appears before motor neuron death and is paralleled by the development of a specific locomotor deficit affecting speed and limb coordination. This distinct ALS-induced locomotor deficit is phenocopied in wild-type mice but not in SOD1G93A mice after appearing of the locomotor phenotype when V1 spinal interneurons are silenced. Our study identifies a potential source of non-autonomous motor neuronal vulnerability in ALS and links ALS-induced changes in locomotor phenotype to inhibitory V1-interneurons.
Protein nanofibrils for next generation sustainable water purification
Authors: Peydayesh Mohammad , Mezzenga Raffaele
Published: May 2021

Water scarcity is rapidly spreading across the planet, threatening the population across the five continents and calling for global sustainable solutions. Water reclamation is the most ecological approach for supplying clean drinking water. However, current water purification technologies are seldom sustainable, due to high-energy consumption and negative environmental footprint. Here, we review the cutting-edge technologies based on protein nanofibrils as water purification agents and we highlight the benefits of this green, efficient and affordable solution to alleviate the global water crisis. We discuss the different protein nanofibrils agents available and analyze them in terms of performance, range of applicability and sustainability. We underline the unique opportunity of designing protein nanofibrils for efficient water purification starting from food waste, as well as cattle, agricultural or dairy industry byproducts, allowing simultaneous environmental, economic and social benefits and we present a case analysis, including a detailed life cycle assessment, to establish their sustainable footprint against other common natural-based adsorbents, anticipating a bright future for this water purification approach.