bluuebunny/crossref_metadata_2025 huggingface dataset:
Exome sequencing identified a novel pathogenic RET variant with high variable expressivity and incomplete penetrance in an extended pedigree with Hirschsprung disease
Authors: Rahnavard Sahereh , eghbali maryam , saei hassan , Ashjaei bahar , abiri maryam
Published: April 2020

Background: Hirschsprung disease (HSCR) is a developmental disorder characterized by the absence of ganglion cells in the gastrointestinal tract, which consequences in intestinal obstruction. HSCR has more than 80% heritability, including two major forms as sporadically which is the most common form with a complex pattern of inheritance and other forms appear with a familial/syndromic basis along with Mendelian inheritance and incomplete penetrance. The rare and common sequence variants in genes related to the enteric nervous system (ENS) was identified to play a critical role in the progress of HSCR. Results: This study aimed to investigate the genetic basis of an Iranian extended family with different manifestations such as inherited HSCR, chronic constipation, congenital malformations (single kidney and closed anus) to find the causal mutations. To uncover the contributing genetic variant/s, exome sequencing was performed on proband (IV-V). Finally, with the standard filtering protocol, we identified a novel heterozygous nonsense mutation, p.Y314X at exon 5 of the RET gene. This variant is located in the extracellular domain of RET tyrosine kinase and subsequently leads to no detectable RET full-length protein and so may lead to protein loss of function. This devastating variant is manifested in the proband, with long‐segment form and other phenotypes such as single kidney, absent of peritoneum and pigmentation of the face. However, this variant has been segregated in the mother (III-IV, with single kidney), the grandmother (II-II, with diarrhea) and the aunt (III-V, with chronic constipation and premature ovarian failure); these members of the family didn’t show HSCR. Furthermore, in other members of the family (II-IV and III-XII) with chronic constipation and no HSCR, the variant was detected. Nonetheless, this phenomenon can be interpreted by incomplete or reduced penetrance in this extended family with variable expression. Conclusions: The present study found a novel null variant at RET gene that is associated with a wide range of phenotypes and incomplete penetrance. This can be synergistic effects of rare and/or common variants among known and/or unknown disease susceptibility genes which lead to variable severity of phenotype. Such information is important for proper genetic counseling in familial HSCR. Keywords : Hirschsprung disease, whole-exome sequencing, RET novel mutation, extended pedigree, incomplete penetrance.
The clinical data from 19 critically ill patients with Corona Virus Disease 2019: a single-centered, retrospective, observational study﻿
Authors: Zhang Jinping
Published: April 2020

Background To analyze the clinical features of Corona Virus Disease 2019 (COVID-19) and evaluate the diagnosis and treatment.Methods Making retrospective analysis of the clinical manifestation and auxiliary examination of the 19 patients of COVID-19 which from the Liyuan Hospital ICU between January 16, 2020 and February 20, 2020.Results There were 11 male and 8 female cases among the patients. The median (range) age was 73 (38-91) years. There are 8（42.1%）patients had died , and the median duration from ICU to death was 2 (IQR: 1–10.75) days in non-survivors. Seven patients have the basic diseases which in the dead patients. Auxiliary examination: fever (68.4%), dry cough (15.8%), dyspnea (10.5%), diarrhea (5.3%). 19 cases (100%) showed ground-glass changes on Chest computed tomography. Serum Hypersensitive C-Reactive Protein (hs-CRP) and Serum Amylase A (SAA) were increased obviously of 19 cases (100%); there are 16（84.2%）cases which the total number of lymphocytes decreased; 12 cases (63%) liver function; 11 cases (58%) were deviant in fibrinogen (FIB) and D-dimer, in particular, the D-dimer was significantly higher compared with the non-survivors and survivors.Conclusion More men than women in critically ill patients. All the cases showed ground-glass changes on chest CT, and the vast majority of patients will appear fever and dry cough. Clinical lab index changes obviously, especially the D-dimer in Non-survivors.
Construction of a Full-length Infectious Clone of Zika Virus Stably Expressing EGFP Marker in a Eukaryotic Expression System
Authors: Gao Jing , Shi Lingjuan , Chen Jiayi , Lu Weizhi , Cai Jingtai , Zhao Wei , Zhang Bao
Published: April 2020

Background: Zika virus is among the most widely transmitted arboviruses in the world and closely associated with diseases, such as encephalitis, fetal microcephaly, and Guillain–Barré syndrome. The pathogenic mechanism of the virus has not been fully elucidated, and there are no vaccines or specific drugs targeting the virus. To address these issues, the application of reverse genetics is needed for viral reconstruction and reproduction.Methods: Polymerase chain reaction (PCR) was used to merge the full-length Zika virus genome, CMV promoter, intron, EGFP, hepatitis delta virus ribozyme, and SV40 terminator sequence for cloning into a pBAC11 vector through recombination to produce recombinant pBAC-ZIKA-EGFP. The ZIKA–EGFP was rescued by transfection of 293T cells with pBAC-ZIKA-EGFP, and at 7-days post-transfection, the supernatant (P0 generation) was passed through a 0.45-μm membrane and used to infect Vero cells (to produce the P1 generation). Fluorescence-based quantitative PCR, 50% tissue culture infectious dose, and plaque assays were used to measure differences in replication ability and pathogenicity relative to the rescue virus (ZIKA–WT), the sequence of which is consistent with that of the wild-type Zika virus. Additionally, caffeic acid phenethyl ester (CAPE), a nuclear factor kappaB (NF-kB) inhibitor, was used to examine its effect on viral replication.Results: The results showed that ZIKA–EGFP could effectively infect Vero cells, SH-SY5Y cells and C6/36 cells, and cause cytopathic effects on them. ZIKA–EGFP exhibited stable replication and EGFP expression during cell passage for at least six generations, with no significant difference in replication ability relative to the ZIKA–WT. Fluorescent cell foci were observed in the plaque assay while the ZIKA–EGFP was in the absence of phage plaque formation. The inhibition of NF-kB inhibitor on ZIKA-EGFP was observed by fluorescence microscopy, which was consistent with the results of fluorescence quantitative PCR.Conclusions: We constructed an infectious clone of the full-length genome of Zika virus which could replicate with stable EGFP expression in eukaryotic cells during passage. The infectious clone, remaining main characteristics of wild type ZIKA virus could be appied on the studies of reverse genetics, drug screening and gene function of ZIKA virus.
Characteristics of three-dimensional acetabular morphology of patients with excellent outcome after rotational acetabular osteotomy over 20 years
Authors: Tanaka Takeyuki , Moro Toru , Ishikura Hisatoshi , Hashikura Kazuaki , Kaneko Taizo , Tanaka Sakae
Published: April 2020

Background Rotational acetabular osteotomy (RAO) is a type of pelvic osteotomy performed to improve the acetabular bony coverage against the femoral head for patients with acetabular dysplasia. The acetabular bony coverage is ideally evaluated three-dimensionally; however, there is a paucity of published data regarding three-dimensional morphology in patients with long-term excellent outcome after RAO. The present study investigated the characteristics of three-dimensional acetabular morphology with long-term excellent outcome after RAO in comparison to patients with normal hip joints and those converted to total hip arthroplasty (THA) after RAO because of osteoarthritis (OA) progression. Methods Anteroposterior plain radiograph and computed tomography data of 57 hip joints (17 joints with excellent outcome 20 years or more after RAO, 16 normal joints, and 20 joints converted to THA after RAO) were analyzed. The two-dimensional lateral center-edge (CE) angle from plain radiographs, acetabular anteversion, anterior acetabular sector angle, and posterior sector angle from computed tomography (CT) images were calculated. Results Compared with patients converted to THA, all parameters in patients with long-term excellent outcome after RAO were similar to those in patients with normal hip joints, particularly in the three-dimensional analyses. The anterior bony coverage was excessive, whereas the posterior bony coverage was deficient in patients converted to THA after RAO. Anterior bony impingement and posterior instability may be the cause of OA progression after RAO. Conclusion Caution must be taken to avoid rotating the separated fragment excessively to the anterior direction during RAO to prevent OA progression and achieve long-term excellent outcome.
GDNF and GUCY2C mutation associated with Hirschsprung's disease in a trio pedigree: a case report
Authors: Chai Senmao , Deng Kai , Sun Xiaodong , Zhao Qiang , Fu Pan , Xu Qianqian , Sang Ming
Published: April 2020

Background: Hirschsprung's disease (HSCR) caused by absence or dysfunction of ganglion cells in the submucosal plexus and intermuscular plexus of the intestinal wall. Studies have shown that homozygous mutations of glial cell-line derived neurotrophic factor ( GDNF ) can lead to the occurrence of HSCR. but heterozygous mutation must combine with other related abnormal genes could to cause the HSCR. The other Guanylyl cyclase C ( GUCY2C ) gene is rarely reported as a direct cause of HSCR. Our findings Provides a new perspective for application of mutation screening in the genetic counseling.Case presentation: We report clinical and genetic findings of a trio pedigree with Hirschsprung's disease. Whole exome sequencing and Sanger sequencing were performed for propositus and all members of trio pedigree, respectively. We also collected 74 healthy control samples and used Sanger sequencing to identify that found the mutation. We first described the rare trio pedigree of HSCR caused by two special genes of GDNF (p.Arg93Gln) and GUCY2C (p.Tyr1072Cys). Studies have found that mutations in GDNF alone do not cause HSCR symptom, so is propositus’ mother in this study. Common mutation of GDNF gene mutation inherited from mother of proband, but the rare mutation of GUCY2C from the father. None of the parents showed HSCR phenotype. We provide evidence for the causative role of the two variants.Conclusions: Our study found that GDNF and GUCY2C together lead to the occurrence of HSCR. This finding expands the genotype spectrum and increases knowledge on the genetic molecular mechanisms of the HSCR. Our findings will provide help for the screening of pathogenic genes of HSCR.
Studi Karakteristik Sarang Orangutan (Pongo pygmaeus morio) di Resort Sangatta dan Resort Sangkima Taman Nasional Kutai
Authors: Tikurara Londong Allo Marcelina , Kisworo  , Pakpahan Suhendra
Published: April 2020

Orangutan (Pongo pygmaeus morio) merupakan satwa langka yang harus dikonservasi melalui pelestarian Taman Nasional Kutai (TNK). Studi karakteristik sarang orangutan merupakan bagian dari upaya pelestarian. Metode yang digunakan dalam penelitian ini adalah menggunakan jalur transek dengan menghitung sarang orangutan serta mencatat karakteristik sarang orangutan yang meliputi kelas sarang, posisi sarang, tinggi sarang, tinggi pohon, diameter pohon dan jenis pohon sarang. Pada lokasi penelitian ditemukan sebanyak 173 sarang orangutan yang terdiri dari 84 sarang di resort Sangatta dan 89 sarang di resort Sangkima. Jenis sarang didominasi oleh kelas sarang C dan D dengan posisi sarang sebagian besar terdapat pada ujung dahan (UD) di resort Sangatta, posisi sarang terbanyak ada pada ujung dahan (UD) dan pucuk pohon (PP) di resort Sangkima. Rata-rata tinggi sarang orangutan adalah 12,2 - 40,2 m, diameter pohon 17,4 - 110 cm, dan tinggi pohon 12,2 - 40,2 m di resort Sangatta. Pada resort Sangkima rata-rata tinggi sarang orangutan adalah 10,2 - 24,2 m dengan diameter pohon 20 - 109,4 cm dan rata-rata tinggi pohon 14-28,6 m. Karakteristik sarang orangutan menjadi indikator kondisi habitat orangutan yang ada di TNK
Peripheral Immunosenescence and Central Neuroinflammation: A Dangerous Liaison - A Dietary Approach
Authors: Magrone Thea , Magrone Manrico , Russo Matteo A. , Jirillo Emilio
Published: April 2020

Background & Objectives:

In old people, both innate and adaptive immune responses are
impaired, thus leading to a condition of systemic inflamm-ageing, even including the involvement of
the central nervous system (CNS).

Aims:

Here, main mechanisms of the immune ageing and neuro-inflammation will be discussed along
with the dietary approaches for the modulation of age related diseases.

Discussion:

Neuroinflammation is caused by the passage of inflammatory mediators through the brain
blood barrier to CNS. Then, in the brain, antigenic stimulation of microglia and/or its activation by
peripheral cytokines lead to a robust production of free radicals with another wave of proinflammatory
cytokines which, in turn, causes massive neuronal damage. Also, infiltrating T cells [T
helper (h) and T cytotoxic cells] contribute to neuronal damage. Additionally, a peripheral imbalance
between inflammatory Th17 cells and anti-inflammatory T regulatory cells seems to be prevalent in the
aged brain, thus leading to a proinflammatory profile. Alzheimer’s disease, Parkinson’s disease and
multiple sclerosis will be described as typical neurodegenerative diseases. Finally, modulation of the
immune response thanks to the anti-oxidant and anti-inflammatory effects exerted by dietary products
and nutraceuticals in ageing will be discussed. Special emphasis will be placed on polyunsaturated
fatty acids, polyphenols, micronutrients and pre-probiotics and synbiotics.

Conclusion:

Ageing is characterized by an imbalance subversion of the immune system with a condition
of inflamm-ageing. Neuroinflammation and neurodegenerative diseases seem to be a central manifestation
of a peripheral perturbation of the immune machinery. Dietary products and nutraceuticals
may lead to a down-regulation of the oxidative and pro-inflammatory profile in ageing.
Web-based thematic module in social studies to improving student digital literation skills
Authors: Zahroh Nur Lailatus
Published: April 2020

Web-based thematic modules were developed based on the needs of social studies teachers and students of a media that collects social science material in an integrated and thematic manner that is easily accessible and flexible. This study aims to (1) find out the procedures for developing and making web-based modules on IPS material, (2) knowing the students' responses after using the WEB-based module as teaching material for social studies, (3) knowing the effectiveness of WEB-based modules viewed from student learning outcomes. The method used is the Research and Development method with a three-stage development model; there are design, production, and evaluation. The results of this study are (1) WEB-based thematic modules developed in two themes, namely the first theme of forest and land fires in Kalimantan and the second theme of the Industrial Revolution 4.0, (2) as for student responses to the use of this web-based thematic module product, in general, give a positive response. Although they found obstacles that were difficult to concentrate when studying with WEB, (3) the effectiveness of the product seen from student learning outcomes showed that this WEB-based module did not have a significant positive impact on student learning outcomes. 46.03% of students entered the category of mastering, and 53.94% of students entered the category of not mastering, so that shows the level of digital literacy of students is still low.
Molecular Characterization of Betasatellite Associated with Begomovirus on Ageratum conyzoides in Magelang, Central Java
Authors: Kandito Argawi , Hartono Sedyo , Sulandari Sri , Somowiyarjo Susamto
Published: April 2020

Ageratum conyzoides is one of the common weeds in Indonesia. The presence of weed can decrease plant yield by resource competition and its role as alternative hosts for pests and diseases, especially begomoviruses transmitted by whitefly. The aim of this research is to detect and characterize the begomovirus-beta satellite in A. conyzoides. A. conyzoides showed severe yellowing symptoms were collected from Magelang, Central Java, Indonesia. Total DNA was extracted and analyzed using PCR method for begomovirus and beta satellite. Begomovirus detection was performed with universal primer Krusty-Homer, resulted a 500 bp DNA fragment. Betasatelit detection performed with specific primer β01/β02, resulted a 1300 bp DNA fragment, indicated presence of a beta satellite associated with the begomovirus. The sequence of begomovirus showed 95% similarity with Tomato Leaf Curl Java Virus (ToLCJaV). The sequence of beta satellites showed 85% similarity with Tomato Leaf Curl Betasatellite (ToLCB). Characterization of beta satellite showed three main characters of beta satellite, TAATATTAC stem-loop structure, Adenine-rich region, and 118 amino acids of putative ORF BC1.
Formación del profesorado de Primaria defendiendo la diversidad y la inclusión. Memoria de un caso de experiencia docente a través de Museari
Authors: Huerta Ricard
Published: April 2020

Entre as possibilidades do ensino da arte destacam-se as questões da reivindicação social, especialmente a luta pela equidade e o respeito às minorias. Dentro dessa corrente socializadora, os avanços em gênero e diversidade são enquadrados. A luta pelos direitos humanos torna-se assim um lugar comum a partir do qual se implementam políticas culturais e inovações educacionais. Trabalhamos nessa linha há três décadas, conscientes da necessidade de nos envolvermos nos avanços que promovem a convivência e o equilíbrio social. Há cinco anos, criamos o museu on-line Museari para desenvolver projetos e melhorar a situação de grupos minoritários usando o ambiente on-line para coordenar esforços e gerar redes entre os professores.
Çelik Liflerin Geometrik Şeklinin ve Oranının Beton Özelliklerine Etkisinin Araştırılması
Authors: ŞİMŞEK Osman , TOKLU Kenan , ÜNAL Muhammed Talha
Published: April 2020

Birçok araştırmada betonun teknik özelliklerini artırmak için farklı cins ve tiplerdeki liflerle çalışmalar yapılmıştır. Genellikle son yıllarda betonun mekanik özeliklerinin öncelikli olan yerlerde çelik lif tercih edilmektedir. Bu çalışmada, tarafımızca şekil verilerek oluşturulan 2 farklı çelik lif tipi (Z, C şeklinde) ve 80/60 çelik lifi, çimento ağılığının 0.0, 0.10, 0.15 ve 0.20 oranlarında kullanılmıştır. Bu farklı şekillere sahip çelik liflerin, taze betonda oluşturdukları hava %’si miktarı ve işlenebilme özelliği gözlenirken; sertleşmiş betonda ise basınç, eğilme ve aşınma dayanımlarına olan etkileri incelenmiştir. Lifin şekli ve oranının, taze ve sertleşmiş beton özellikleri üzerinde etkili olduğu görülmüştür. Taze ve sertleşmiş betonda en optimum özellik, 80/60 lifinin %10 kullanılmasıyla elde edilmiştir.
Live Music and Festivals
Authors: O’Reilly Dr Daragh , Larsen Dr Gretchen , Kubacki Dr Krzysztof
Published: April 2020

The purpose of this chapter is to explore the importance of live music, music venues, music festivals and live music promotion in the production and consumption of music. As shown in Chapter 3, music is a complex product which can be enjoyed in a wide range of social situations, from listening to music in one’s own home or car, through enjoying a concert in a large music venue like an opera house or stadium, to spending several days at a music festival attended by over a million people. This chapter therefore begins with an attempt to provide an understanding of some of the historical developments of live music, its main characteristics, and the reasons behind its growing popularity. Music festivals are an important variant of live music, and the chapter also includes a discussion of the nature, form and function of music festivals, their multiple impacts and the marketing issues which they present.
Linguo-legal convergence: foreign trade discourse
Authors: Gyul’verdiev Ramu Beyukhanovich
Published: April 2020

The expansion of international contacts and integration policy of Russian mainstream the question of development of linguistic grounds for effective interlingual communication, thus special attention is given to the problem of building nominative field of frame-scenario of linguo-legal convergence as a type of linguocultural concept, which main purpose consists in systematization and substantiation of a set of translation strategies. Based on the analysis of the models of representation of knowledge, it would contain the results of identification of national-cultural and mental specifics of language structures. Multi-aspect examination of the problems of legal translation justifies utilization of complex methodology that includes linguo-legal, linguo-culturological and comparative analysis. The author also applies statistical, comparative-legal and comparative methods in studying the foreign practice, scientific works, business documentation, which allow formulating and introducing recommendations aimed and increasing effectiveness and optimization of activity in the indicated sphere. The conclusion is made that the frame-scenario may significantly assist in translation of contracts as a results of time-consuming and detailed work of the translators-interpreters, which would integrate the ontological properties of the meaning of text. The author determines the key trajectories of cognitive study of linguo-legal convergence in the foreign trade discourse.  
Criminal-legal protection of competition in the United States
Authors: Danilovskaia Anna
Published: April 2020

The subject of this research is the legislation and law enforcement in the area of criminal-legal protection of competition in the United States. The questions of counteracting encroachment upon competition alongside protection of rights of economic entities and consumers in case of unfair competition are one of the most relevant in the world. According to separate assessment, the U. S. antitrust legislation is recognized as most efficient. Its establishment, development, and application contributed to emergence of the generally accepted principles of protection of competition, such as per se and the rule of reason. Modern approaches towards restraint of violation of antitrust legislation determined the new trends in development of both, normative acts and judicial practice. Criminal legal protection of competition in the United States is characterized by strict prohibitions, high sanctions, presence of criminal-procedural authority of Antitrust Administration of the U. S. Ministry of Justice, as well as program of mitigation of responsibility for cartels. The goal of study lies in the analysis of legislation and law enforcement in the area of protection of competition in the United States for assessing the existing experience. The novelty consists in proposal of the author to take into account the U. S. experience with regards to countering encroachment upon competition, which can be valuable particularly in revision of the Article 178 of the Criminal Code of the Russian Federation, improvement of the program of mitigation of responsibility for cartels, systematization of the compositions of crime related to unfair competition, cooperation of anti-monopoly agencies and law enforcement authorities. The research results can be used in the work of Federal Anti-Monopoly Service, as well as educational process and scientific activity.
Avaliação geoespacial da expansão do aglomerado urbano Crajubar utilizando inteligência geográfica
Authors: Teles Rudá Peixoto , Gomes da Silva Maria Lucineide , Alves Ribeiro Antonio Junior
Published: April 2020

Na região Nordeste do Brasil existe uma gama de aglomerações urbanas, dentre as quais se destaca a conurbação urbana, conhecida como Crajubar, localizada na Região Metropolitana do Cariri (RMC), no sul do Ceará, onde existe uma percepção de ausência de limites urbanos entre os três municípios: Crato, Juazeiro do Norte e Barbalha. Assim, este trabalho busca compreender a dinâmica da expansão do Crajubar, por meio de técnicas de Geoprocessamento. Para tanto, utilizou-se arquivos vetoriais da delimitação territorial com mancha urbana do ano de 2005 e imagens orbitais dos satélites GeoEye do ano de 2018. Para o processamento dos dados foi utilizado o software QGIS. O Google Earth foi usado para identificar estabelecimentos responsáveis por atraírem crescimento urbano para o seu entorno, ainda foram utilizadas informações oficiais de crescimento populacional e informações econômicas geradas pelos órgãos oficiais. Como resultados, geraram-se arquivos vetoriais com duas manchas urbanas da região, sendo uma de 2005 e outra de 2018, as quais apresentam a conurbação dos três municípios para as duas situações. A partir do mapa gerado, construiu-se o entendimento dos fatores que impulsionam a expansão espacial urbana do Crajubar, tais como serviços públicos nas áreas de infraestrutura, saúde e educação. Evaluation of expansion of Crajubar urban agglomerate using geomatics A B S T R A C TIn the Northeast region of Brazil there is a range of urban agglomerations, among which the urban conurbation known as Crajubar. It is located in the metropolitan area of Cariri (MAC), in the south of Ceará, where there is a perception of the absence of urban boundaries between the three towns: Crato, Juazeiro do Norte and Barbalha. This work tries to understand the dynamics of the expansion of Crajubar, using Geoprocessing techniques. It was used shapefiles of the territorial delimitation with urban area of the year of 2005 and GeoEye satellites images of the year of 2018. The QGIS software was used for data processing. The Google Earth was used to identify companies and institutions responsible for attracting urban growth for the around their area, official information on population growth and economic information generated by government institutions was also used. As a result, shapefiles were generated with two urban areas in the region, one of area in 2005 and another area in 2018, where each one presents the conurbation of the three towns for both situations. From the generated map, the understanding of the factors that have influenced the urban spatial expansion of Crajubar was constructed, such as public services of infrastructure, health and education.Keywords: Urbanization, Population Growth, Geoprocessing.
EDUCATION AND BUSINESS PARTNERSHIP: IN SEARCH OF NEW FORMS OF INTERACTION
Authors: Khoruzha Liudmyla , Tadeush Olena
Published: April 2020

The article analyzes modern approaches to the partnership interaction between education and business, characterizes the specific features and modern forms of partnership interaction between higher educational institutions and business corporations. The authors have established that the partnership between higher education and business is a very specific type of cooperation and involves a wide range of activities, multifaceted goals and multifunctional opportunities. The researchers emphasize that establishing a productive mechanism for cooperation between universities and business will increase the efficiency of educational activities and develop ways of technology transfer to production, because this partnership is mutually beneficial, since the university receives additional financial resources and practical focus of its activities and the company gets qualified professionals and advanced technologies. The authors have described the Master’s Educational and Professional Program «Corporate Education and Staff Development» in Specialty 011 «Educational, Pedagogical Sciences». The purpose of the educational program is to provide theoretical and practical training for the specialists capable of creating and operating alternative education systems in corporations and enterprises that provide training, advanced studies and continuous development of the staff in accordance with the strategic goals and objectives of these institutions. The authors have presented the content of the educational program, competencies and program outputs, a selective block of educational disciplines and prospects for employment of graduates.
Education Policy Overcome Coronavirus, A Study of Indonesians
Authors: Wajdi Muh Barid Nizarudin , Iwan Kuswandi  , Umar Al Faruq  , Zulhijra Zulhijra , Khairudin Khairudin , Khoiriyah Khoiriyah
Published: April 2020

The COVID-19 or Coronavirus that encircled Indonesia seems to be unmuted. Its massive and relatively fast spread makes people feel scared. Everyone is forced to remain at home to break the COVID-19 transmission chain. Mass agenda eliminated because of COVID-19 also the term work from home (WFH) so popular.  COVID-19 also has a serious impact on the education sector in Indonesia. Here are some policies in the world of education taken by the Indonesian government in the emergency period of Coronavirus (COVID-19) year 2020.  This article aims to discuss government policy, especially about the education policy to deal with Coronaviruses. The results showed that some government policies related to education in the time Coronavirus could minimize the spread of coronaviruses. These policies include online learning for school children, online lectures, national Examinations 2020 canceled, UTBK SBMPTN 2020 postponed, the implementation for SNMPTN still in review
KONSEP PENDIDIKAN ISLAM DALAM PERSPEKTIF KIAI HAJI AHMAD DAHLAN
Authors: Mubaroq Ahmad Isa , Maulana Aslich , Basri Hasan
Published: April 2020

Tujuan mendeskripsikan konsep pendidikan K.H Ahmad Dahlan. Metode penelitian yang digunakan adalah metode penelitian Library Research. Pengumpulan data dilakukan dengan cara mengumpulkan data-data yang berkaitan dengan konsep pendidikan K.H Ahmad Dahlan dari beberapa buku kemudian memberikan deskripsi lalu di simpulkan. Hasil pembahasan yang ditulis ini ada pertama konsep pendidikan menurut K.H Ahmad Dahlan menganggap yang menjadi target paling penting dalam tujuan pendidikan adalah pembentukan kepribadian. Kedua, tujuan pendidikan menurut K.H Ahmad Dahlan adalah Baik budi pekertinya, alim dalam agama, luas pengetahuan dalam ilmu dunia (umum), dan bersedia memperjuangkan kemajuan masyarakat. Ketiga, Model Pendidikan yang baik menurut K.H Ahmad Dahlan adalah pendidikan yang sesuai dengan kebutuhan masyarakat saat ini di mana peserta didik tersebut berada. Keempat, K.H Ahmad Dahlan melakukan pembaharuan pendidikan dengan cara memasukkan pelajaran agama di setiap sekolah umum
PERAN GURU PENDIDIKAN AGAMA ISLAM DALAM MENDISIPLINKAN SHALAT BERJAMA’AH PESERTA DIDIK DI SMK MUHAMMADIYAH 3 GRESIK
Authors: Anggraini Nurullia , Amirudin Noor
Published: April 2020

Shalat adalah media komunikasi antara makhluk dan sang khalik. Shalat adalah pencegah dari perbuatan keji dan munkar. Kalau melihat realitas sekarang di kalangan remaja sudah banyak terjadi kelalaian dalam banyak hal. Oleh karena itu, perlu adanya kebiasaan shalat berjamaah di sekolah agar pembiasaan baik sejak dini tertanam dalam diri remaja. Penelitian ini difokuskan pada peran guru PAI dalam mendisiplinkan shalat berjamaah peserta didik di SMK Muhammadiyah 3 Gresik dengan rumusan masalah sebagai berikut: (1) peran guru PAI dalam mendisiplinkan shalat berjamaah peserta didik (2) faktor pendukung dan penghambat dalam mendisiplinkan shalat berjamaah peserta didik. Untuk mencapai tujuan tersebut menggunakan metode deskriptif kualitatif, adapun pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Peneliti menggunakan analisis deskriptif yang bertujuan untuk menjelaskan aspek yang relevan dengan fenomena yang diamati. Hasil penelitian menunjukkan bahwa: (1) Guru memberikan contoh (sebagai teladan yang baik), memberikan nasihat yang baik, memberikan hukuman, (2) kerja sama yang baik antara guru PAI dan guru yang lain, peran guru PAI yang berjalan dengan baik, lokasi, dan waktu. Dengan diadakan shalat berjamaah di sekolah maka akan menjadikan siswa terbiasa melakukan shalat berjamaah di mana pun dengan tepat waktu. Kegiatan ini sangat baik dilaksanakan karena sesuai dengan kurikulum tentang shalat yang selanjutnya dapat mengaplikasikan kegiatan di sekolah maupun di rumah. Kegiatan shalat berjamaah tersebut dengan maksud untuk mendisiplinkan shalat berjamaah peserta didik.
PEMBIASAAN MEMBACA AL-QUR’AN DI PONDOK AL-ISHLAH SENDANGAGUNG PACIRAN LAMONGAN
Authors: Apriyanti Eva , Basri Hasan
Published: April 2020

Abstrak: Penelitian ini merupakan penelitian kualitatif. Menggunakan metode penelitian sebagai berikut: 1) jenis pola penelitian kualitatif, 2) sumber data : narasumber, kepada guru, ustazah, pengasuh pondok dan santri, OPPI, pengumpulan data dilakukan dengan menggunakan metode observasi, wawancara dan dokumentasi, 4) teknis analisis data adalah reduksi data, penyajian data, dan penarikan kesimpulan dan berdasarkan data yang diperoleh tersebut peneliti menganalisis menggunakan analisis deskriptif, yaitu dengan mendeskripsikan atau menggambarkan apa adanya hasil temuan di lapangan terkait pembiasaan membaca Al-Qur’an di pondok Al-Ishlah Sendangagung Paciran Lamongan. Hasil penelitian skripsi ini adalah 1) untuk mengetahui proses pembiasaan membaca Al-Qur’an dan untuk mendukung pembiasaan agar mencapai hasil yang lebih efektif maka digunakan beberapa metode atau cara dalam membaca Al-Qur’an yaitu: metode penugasan, metode teman sejawat, metode khusus atau privat, metode klasikal. Faktor pendukung dalam pelaksanaan pembiasaan membaca Al-Qur’an adalah Bahwa terdapat peran penting pengurus dan pembimbing dalam kegiatan proses pembiasaan membaca Al-Qur’an di pondok Al-Ishlah Sendangagung Paciran Lamongan, dan pengurus dan pembimbing dituntut untuk bekerja sama dalam pembelajaran dan pembiasaan membaca Al-Qur’an. Hal ini tidak lain dikarenakan adanya kultur atau budaya membaca Al-Qur’an yang melekat di dalam pondok Al-Ishlah Sendangagung sedangkan faktor penghambatnya adalah kurang motivasi diri. Masih banyak santri yang tidak lancar atau belum bisa mengaji, minimnya tenaga pengajar yang benar-benar ahli tahsin (membaca Al-Qur’an).
Комбінований метод нечіткої кластеризації даних в системах технічної діагностики
Authors: Удовенко С.Г. , Келембет Д.В. , Тесленко О.В.
Published: April 2020

У статті наведено результати аналізу методів нечіткої кластеризації даних поточних спостережень в технічних системах. Запропоновано і протестовано комбінований підхід до нечіткої кластеризації даних з використанням комбінації алгоритму Густафсона-Кесселя, методу остовного лісу та фільтра Калмана, що може бути використаний в системах технічної діагностики (зокрема, діагностики стану основних параметрів технологічних процесів). Розглянуто можливість подальшого розширення функціональних можливостей наведеного комбінованого методу кластеризації з наданням йому адаптивних властивостей. Наведено результати тестування та визначено переваги запропонованого підходу.
MENGIDENTIFIKASI TAHAPAN-TAHAPAN METODOLOGI ANALISIS AUDIT SISTEM INFORMASI
Authors: Winariyani
Published: April 2020

Audit Sistem Informasi merupakan proses pengumpulan dan pengevaluasian buktibukti untuk menentukan apakah suatu sistem aplikasi komputerisasi telah menetapkan dan menerapkan sistem pengendalian intern yang memadai, semua aktiva dilindungi dengan baik atau tidak disalahgunakan serta terjaminnya integritas data, keandalan serta efektifitas dan efisiensi penyelenggaraan sistem informasi berbasis komputer. Disini kita akan mengidentifikasi tentang tahapan-tahapan metodologi analisis audit sistem informasi. Audit sistem informasi melakukan tinjauan atas pengendalian untuk menilai kesesuaiannya dengan kebijakan dan prosedur pengendalian serta efektivitas dalam menjaga aset perusahaan. Dengan kata lain Audit Sistem Informasi adalah proses pengumpulan dan pengevaluasian bukti-bukti untuk membuktikan dan menentukan apakah sistem aplikasi komputerisasi yang digunakan telah menetapkan dan menerapkan sistem pengendalian intern yang memadai, apakah aset organisasi sudah dilindungi dengan baik dan tidak disalah gunakan, apakah mampu menjaga integritas data, kehandalan serta efektifitas dan efisiensi penyelenggaraan sistem informasi berbasis komputer.
Expedient behaviour and predetermination at the Ciota Ciara cave (north-western Italy) during Middle Palaeolithic.
Authors: Daffara Sara , Berruti Gabriele L.F. , Arzarello Marta
Published: April 2020

The Ciota Ciara cave is a Middle Palaeolithic site located in Piedmont (north-western Italy) and it is the only one systematically investigated in the region. It opens at 670 m a.s.l. on the west side of Monte Fenera and its archaeological deposit has a stratigraphic sequence documenting several and repeated human frequentations. Four archaeological layers have been identified (13, 14, 15 and 103) and are characterized by lithic assemblages where vein quartz is the main exploited raw material. The upper level (13), was already subject to technological and functional studies but the enlargement of the excavated area made necessary a completion of the technological data. The aim of this work is to deal with a complete technological and functional study of the lithic assemblage of the four archaeological layers of the Ciota Ciara cave to face the issues of predetermination and adaptation of the reduction sequences to the raw materials features. The technological analysis is based on the concept of chaîne opératoire and refers to the classical definitions of the S.S.D.A., discoid and Levallois methods for the identification of the different exploitation strategies. The concepts of curated and expedient technology are also applied to the present study. We finally refer to the huge debate concerning the concept of predetermination related to cores that show reduced or none phases of core configuration for the analysis and interpretation of the considered lithic assemblage.The results obtained show that the general behaviour can be interpreted as expedient, both from a technological and a functional point of view. The Middle Palaeolithic hunter-gatherers of the Ciota Ciara cave adapted their “technological background” to the resources available and put into action flexible adaptation strategies. Even in the shortness or absence of phases of core configuration, predetermination can be observed in the adaptation of Levallois and discoid concepts to the natural constraints of the pebbles chosen as cores. The natural convexities are exploited to obtain Levallois and discoid flakes after an intentional choice made by the knappers. In order to deeply investigate the characteristics of the technological behaviour of the hunter-gatherers that inhabited the site, the use-wear analysis is a fundamental additional source of information and it is here aimed to understand if there is or not a differential use of the lithic artefacts according to their typology and/or to the knapping method.
Modeling compliance with COVID-19 prevention guidelines: The critical role of trust in science
Authors: Plohl Nejc , Musil Bojan
Published: April 2020

The ongoing coronavirus pandemic is one of the biggest health crises of our time. In response to this global problem, various institutions around the world had soon issued evidence-based prevention guidelines. However, these guidelines, which were designed to slow the spread of COVID-19 and contribute to public well-being, are deliberately disregarded or ignored by some individuals. In the present study, we aimed to develop and test a multivariate model that could help us identify individual characteristics that make a person more/less likely to comply with COVID-19 prevention guidelines. A total of 617 participants took part in the online survey and answered several questions related to socio-demographic variables, political conservatism, religious orthodoxy, conspiracy ideation, intellectual curiosity, trust in science, COVID-19 risk perception and compliance with COVID-19 prevention guidelines. The results of structural equation modeling (SEM) show that COVID-19 risk perception and trust in science both independently predict compliance with COVID-19 prevention guidelines, while the remaining variables in the model (political conservatism, religious orthodoxy, conspiracy ideation and intellectual curiosity) do so via the mediating role of trust in science. The described model exhibited an acceptable fit (χ2(1611) = 2485.84, p < .001, CFI = .91, RMSEA = .032, SMR = .055). These findings thus provide empirical support for the proposed multivariate model and underline the importance of trust in science in explaining the different levels of compliance with COVID-19 prevention guidelines.
Who gets evidence-based therapy for psychosis in the six months following a psychiatric hospital admission? Follow-up data from an inpatient randomised controlled trial
Authors: Jacobsen Pamela Charlotte , Taylor Gemma , Stefanova Maria
Published: April 2020

A major barrier to clinicians referring service users with psychosis for psychological therapies is the belief that they will not engage. We investigated therapy receipt after discharge, in a sample of service users who had already demonstrated willingness to engage in psychological therapy during an inpatient admission. We found only one-third of service users (33%; 16/48) had received at least 1 session of evidence-based therapy at 6-month follow-up after discharge. We found that therapy receipt was more common for service users with i) lower delusional distress at discharge, ii) Black or minority ethnic (BME) background, and iii) discharged to an Early Intervention (EI) service.
Asia in the Russian Imagination
Authors: Hacking Jane F. , Hardy Jeffrey S. , Romaniello Matthew P.
Published: April 2020

This special issue of Sibirica is devoted to exploring Russia’s complicated relationship with Asia. Along with an edited volume (Russia in Asia: Imaginations, Interactions, and Realities, forthcoming), it is an outgrowth of the “Asia in the Russian Imagination” conference that was held at the University of Utah in March 2018. This conference brought together an interdisciplinary body of scholars from the United States, Canada, and Russia to discuss how Russians imagined and interacted with the peoples of Eurasia. Chronologically this conversation spanned the Russian Empire, Soviet Union, and post-Soviet Russia, and included not just the geography and peoples possessed by Russia but also the bordering states of Japan, China, and the Ottoman Empire. This is certainly not a new line of inquiry, but there is still much to be understood about these complex relationships, both real and imagined.
Gender and Empire
Authors: Bourlakov Gwyn
Published: April 2020

The article focuses on the imprisonment of elite women from the Russian metropole and women of mixed ethnic backgrounds on the Siberian frontier in the mid-eighteenth-century. Female prisoners and their monastic jailors responded to ascribed identities, positions, and circumstances dictated by imperial policies within the walls of the Dalmatov Vvedenskii Convent, which complicates our understanding of imperial interaction, gender, and empire in Siberia.
Penerapan Pembelajaran Authentic Instruction Learning dalam Upaya Meningkatkan Pemahaman PKn Siswa
Authors: Hafsah Hafsah , Nursani Nursani
Published: April 2020

Dalam pembentukan sumber daya manusia (SDM) yang berkualitas itu, peranan pendidikan kewarganegaraan khususnya meningkatkan pemahaman PKn sangat  penting, terutama pada jenjang pendidikan menengah. Dapat meningkatkan pemahaman PKn harus memuat empat komponen yang sangat mendasar dalam membaca antara lain mencatat, tugas, observasi, dan presentasi. Tujuan penelitian untuk menjelaskan penerapan pembelajaran authentic instruction learning dalam upaya meningkatkan pemahaman PKn siswa. Metode penelitian ini menggunakan Penelitian ini menggunakan rancangan classroom action research, subyek penelitian sebanyak 38 orang. Pengumpulan data menggunakan observasi dan tes, analisis data menggunakan rumus ketuntasan belajar. Hasil penelitian menunjukkan penerapan pembelajaran Authentic Intruction Learning mampu meningkatkan pemahaman belajar siswa pada mata pelajaran Pendidikan Kewarganegaraan. Hal ini terlihat pada siklus I nilai rata-rata dari 38 siswa adalah 65,52 dengan persentase ketuntasan belajar adalah 57,89%, kemudian pada siklus II nilai rata-rata dari 38 siswa adalah 72.36 dengan persentase ketuntasan belajarnya adalah 78,94%, kemudian pada siklus III diperoleh nilai rata-rata dari 38 siswa adalah 84,47 dengan presentase ketuntasan belajar adalah 100%. Jadi pembelajaran Authentic Instruction Learning disamping mammpu meningkatkan pemahaman konsep PKn, dapat juga meningkatkan sikap kerjasama tim dalam berdiskusi dalam proses pembelajaran.In the establishment of qualified human resources, the role of citizenship education, in particular, enhances the understanding of Civic Education is very important, especially in the secondary education level. Can increase the knowledge of Civic Education should contain four fundamental components in reading, among others, taking notes, tasks, observations, and presentations. The purpose of research to explain the implementation of learning authentic instruction learning to improve the understanding of Civic Education students. This research method uses the research using classroom action research, subject to research as much as 38 people: data collection using observations and tests, data analysis using learning-submission formulas. Instruction Learning was able to improve students ' learning understanding of citizenship education subjects. This was seen on the I cycle. The average value of 38 students is 65.52, with the percentage of learning submission is 57.89%. In cycle II the average cost of 38 students is 72.36, with the interest of the study's presentation is 78.94%. The III cycle obtained an average value of 38 students is 84.47, with a percentage of the learning is 100%. So the teaching of Authentic Instruction Learning, in addition to improving the understanding of the concept of Civic Education, can also increase the attitude of teamwork in the discussion in the learning process.
Officer Professional Education	in the Canadian Forces	and the Rowley Report, 1969
Authors: Wakelam Randall
Published: April 2020

In the late 1960s the Canadian Military was experiencing a peacetime

upheaval. The three previously independent Services were being

amalgamated – unified – by political direction. This meant that previously

independent processes, including professional education, had to be rethought

and reorganized to fit the new single-force philosophy. Under the leadership

of a battlefield commander, Major-General Roger Rowley, a small team set

out to devise a radical concept for academic and professional education that

would provide officers with a coherent suite of learning programs spanning

their careers, all provided for by an integrated single military-civilian teaching

engine. The plan immediately met resistance from pre-existing organizations

and, harried by organizational reductions, faded from the scene, even as the

value of enhanced education was receiving general support. In 2002, with a

renewed focus on intellectual agility, the concept was resurrected with the

establishment of the Canadian Defence Academy.
On the issue of increasing terminological literacy among veterinary specialists (on the example of morphological and parasitological terminology)
Authors: Babichev Nikolay , Akbaev Ramazan
Published: April 2020

In the work on the basis of logical-conceptual and linguistic analysis of a continuous sample of veterinary terms related to morphological and parasitological term systems, the specificity of the terminological apparatus of these Sciences is shown and the existing problems that reduce the terminological literacy of students and specialists in the field of veterinary medicine are revealed. At the same time, the historical mobility and variability of terminology is shown, the conclusion is made about the expediency of using the obtained data in the didactics of veterinary medicine in the preparation of future doctors.