bluuebunny/crossref_metadata_2025 huggingface dataset:
Randomized detection of kdr allele frequencies in wild populations of Aedes aegypti (Diptera, Culicidae) in Colombo District, Sri Lanka
Authors: Induni Chimasha , Mendis B.A.N , Fernando H.S.D. , De Silva B.G.D.N.K
Published: October 2023

Sri Lanka is one of the most affected countries in South Asia by dengue fever, with the number of dengue cases increasing over the last five years. The main strategy for managing disease outbreaks is to reduce infected vector populations with pyrethroid insecticides. However, extensive pyrethroid exposure has resulted in an increase in the selection of knockdown resistance mutations in Aedes aegypti (Linnaeus) (Diptera, Culicidae) voltage-gated sodium channel (vgsc) gene that confer pyrethroid resistance. Colombo district records the highest dengue incidence across the country each year, thus a failed vector control program will be a major threat to public health. Multiplexed Allele-specific PCR was used to genotype kdr alleles in wild Ae. aegypti mosquitoes obtained via random sampling from Wellawatte, Borella, and Battaramulla areas in the Colombo district. This study presents the co-occurrence of F1534C and V1016G kdr mutations from a randomized population in the Colombo district. 1534C mutant allele was predominant (with a 56.7% frequency) and 1016G was prevalent in 32.5 per cent of the population. The heterozygous mutant 1016VG genotype showed the highest distribution (with a 65% frequency) and the incidence of 1534FC was 56.7 per cent. Interestingly, 1016GG was completely absent and the FC/VG mutation combination had the highest incidence with 46.7 per cent. Furthermore, 82.36 per cent of individuals with the 1534FC genotype also had the 1016VG genotype, indicating a high prevalence of pyrethroid resistance in the studied population.
Population dynamics of southern birdwing (Troides minos Cramer, 1779) in Sirumalai Reserve Forest, Tamil Nadu, India
Authors: Archana B. , Sharmila E. Joy , Rangesh K. , Pandi V. , Susaritha S. , Selvi S. Kalai
Published: October 2023

Southern birdwing Troides minos (Cramer, [1779]), a large swallow tail butterfly, state butterfly of Karnataka, is endemic to south India. T. minos was listed in CITES (Convention on International Trade in Endangered species of wild fauna and flora) and is of high conservation priority. IUCN also recommends close monitoring of T. minos. The population trend of T. minos, in Sirumalai Reserve Forest, Eastern Ghats was monitored for the period of twenty six months using the line transect method. Higher prevalence of T. minos butterflies were observed and recorded over the study. This study highlights the abundance of T. minos in certain months of the study period and peak abundance during the post monsoon period.
New distributional records of six Aphodiinae species (Coleoptera, Scarabaeidae) from south India
Authors: Sobhana K.A. , Kumar P. Girish , Thomas Sabu K. , Hegde V.D.
Published: October 2023

Six species (Platytomus indicus (Balthasar, 1941), P. nathani Pittino & Mariani, 1986, Rhyssemus karnatakaensis Pittino, 1984, R. procerus Petrovitz, 1973, R. loebli Petrovitz, 1975 and Neocalaphodius moestus (Fabricius,1801)) of the subfamily Aphodiinae (Coleoptera, Scarabaeidae) are first report from Kerala and two first report from south India. Descriptions of species with images are provided.
Intelectual Capital, Green Accounting, And Company Performance With The Manufacturing Company
Authors: Nuraini
Published: October 2023

This study aims to determine the application of Intelectual Capital green accounting, and company performance with the Manufacturing Company . This research uses quantitative research. The population in this study are mining companies listed on the Manufacturing Company for 2021-2023. The sampling technique used in this study used purposive sampling . The number of companies sampled in this study were 40 companies. The type of data used is secondary data, namely in the form of financial reports and annual reports obtained through the official website of the Indonesia Stock Exchange and the official websites of related companies. The dependent variable used in this study is Company Performance. Meanwhile, the independent variables use intelectual capital and green accounting. The data analysis method used is panel data regression analysis with the help of the SPSS application program. The results of this study indicate that intelectual Capital and green accounting have a positive and significant effect on company performance.
KOMPETENSI PEDAGOGIK GURU DALAM IMPLEMENTASI MODEL PEMBELAJARAN INOVATIF
Authors: Trihantoyo Syunu , Wulandari Ayu , Janah Milla Uzlifatul , Kumairo Mala Nur , Alfi Deyah Nur
Published: October 2023

Pedagogic Competence is the study of Education. Pedagogic Science learns about an ability (expertise) that must be possessed by teachers in the form of the ability to understand students, what methods are appropriate for establishing communication with students, what techniques are used in preparing Learning Designs for students, how to implement learning evaluation, etc. The problem examined in this study is what learning model is designed by the teacher so that students at SDN Sepanjang 2 do not feel bored with the subject matter being directed. Delivering creative, innovative and fun learning materials will make the class atmosphere less saturated, this will make students able to receive lessons easily. The purpose of this research is to see how far the creativity of teachers at SDN Sepanjang 2 develops in delivering material to their students. In the Implementation of Pedagogic Competency schools must provide facilities in the form of adequate facilities and infrastructure so that teachers can optimize the implementation of Pedagogic Competency activities. The research method used in this research is descriptive qualitative method.
KONSEP FILSAFAT PADA PENGEMBANGAN KARAKTER REMAJA MUSLIM DI ERA DUNIA DENGAN GENRE “4P”
Authors: El-Yunusi Muhammad Yusron Maulana , Sajidah Salsabila , Mubarok Husni
Published: October 2023

Abstrak: Dijelaskan bagaimana islam membenahi pendidikan, karakter, akhlak,moral dan tentunya cara berpikir para pemuda pemudi calon penerus generasi bangsa, bagaimana jalan tengah yang paling efektif  untuk mereka tentunya agar dapat membenahi sikap dan sifat pada era global ini serta bagaimana pengaruh kajian islam pada fungsi 4P (Pembenah, Pembenar. Pelindung, Pelopor), bahwa genre 4P ini sangat penting adanya dijamin oleh kitab suci kalamullah, tanpa itu manusia akan selamanya terbengkalai dengan kelalaiannya, stay dengan kerusakkannya dan menghalalkan segala cara tuk mensukseskan hasratnya. Tujuan dalam penelitian ini adalah Membahas perihal pengembangan dan pendidikan karakter dalam islam, tentunya pokok utama adalah niat, mindset dan kesabaran tinggi. Metode yang dipakai dalam penelitian ini kami menggunakan beberapa metode, diantaranya kualitatif, metode ini kami kumpulkan dalam bentuk kata kata, bukan berupa angka bukan pula berupa gambar, kami juga menggunakan beberapa referensi dari website, jurnal, dan artikel. Hasil yang dicapai yaitu diantara metode pembenahan diri yang ada adalah dengan 4P dalam islam, 4P tersebut yakni Pembenahan, Pembenaran, Pelindung, dan Pelopor. 4P tersebut pastinya harus didasari dengan kebajikan dan keikhlasan.Kata Kunci: Karakter Remaja Muslim, Era Genre “4P”
PELAKSANAAN PEMILIHAN PENGADAAN BAHAN PUSTAKA DI PERPUSTAKAAN MADRASAH ALIYAH NEGERI 3 PALEMBANG
Authors: Annur Saipul , Ibrahim Ibrahim , Salsabila Siti Husna
Published: October 2023

Abstract: This study discusses "Implementation of Selection of Library Materials Procurement in the Library of Madrasah Aliyah Negeri 3 Palembang". The purpose of this study is to describe how the implementation of the selection of procurement of library materials in the library of Madrasah Aliyah Negeri 3 Palembang and to analyze the factors that influence the implementation of the selection of procurement of library materials in the library of Madrasah Aliyah Negeri 3 Palembang. The researcher used a qualitative approach with a descriptive type, and the main informants in this study were the head of the library and library staff. Data collection techniques used are observation, interviews, and documentation. The data analysis technique used is data reduction, data presentation and drawing conclusions. Test the validity of research data by source triangulation, technical triangulation and time triangulation. This research was conducted on May 17 – July 3, 2023. The research results obtained by researchers indicated that the implementation of the selection of procurement of library materials in the Palembang 3 Madrasah Aliyah Library is carried out once a year according to user needs. The supporting factors are human resources and infrastructure in the library, while the inhibiting factor is limited funds.Keywords: Implementation, Selection, Library Materials
PERKEMBANGAN PENDIDIKAN ISLAM DI ERA MILENIAL
Authors: Astuti Mardiah , Herlina Herlina , Ibrahim Ibrahim , Nupus Fiona Hayatun , Meilinda Nina , Miranti Miranti
Published: October 2023

Abstract: Islamic education in the current millennial era has experienced significant developments throughout its history, in this millennial era as well. In today's digital and information technology era, the development of Islamic education faces new challenges and an opportunity. It presents how Islamic education adapts to social trends and changes in the current millennial era. The research method used is descriptive qualitative method, with a descriptive approach. The informants of this study were 9 students of the Raden Fatah State University of Palembang, Indonesia. Data was collected through observation, literature study and interviews. Data analysis used descriptive qualitative analysis, so that in-depth conclusions were obtained from the problems studied. The results of this study are first, the form of challenges that occur in the development of Islamic education in the millennial youth era which often occur in the present are: (1) the influence of social media (2) the influence of outside culture (3) technological advances (4) moral decadence ( 5) minimal understanding of religion (6) moral challenges. Researchers found challenges that could affect the development of Islamic education in the current millennial era. Second, important factors that can influence Islamic education in the current millennial era are: (1) having a solid Islamic foundation (2) having strong moral values (3) overcoming the challenges of the times (4) forming an identity (5) build an understanding of Islam (6) develop morals. these factors strengthen to fight challenges in the development of Islamic education in the millennial era.Keywords: Islamic Education, Millennial Era
ANALISIS PENGARUH DISKON, PROMOSI, DAN KEPERCAYAAN KONSUMEN TERHADAP KEPUTUSAN PEMBELIAN PADA PENGGUNA APLIKASI SHOPEE PADA MAHASISWA UNIVERSITAS PENDIDIKAN MANDALIKA PRODI MANAJEMEN ANGKATAN 2021
Authors: Sami`un Sami`un , Hana Fermatika Oktavia
Published: October 2023

Abstract: This research was conducted to find out how much influence Discounts, Promotionsand Consumer Trust haveon Purchase Decisions for Shopee Application Usersin the Mandalika University Of Education student circle. This study uses multiple linear regression analysis method to verify the effect of Discounts, Promotions and Consumer Confidence thataffect the decisions of Mandalika University Of Education students in purchasing products onthe Shopee application. The data used are primary data obtained from the distribution of questionnaires with 60 respondents. The results of this study indicate that there is a significant positive effect of discounts on purchasing decisions for Mandalika University OfEducation students who use the Shopee application. There is a significant positive effect ofpromotion on purchasing decisions for Mandalika University Of Education students who use the Shopee application. There is a significant positive effect of Consumer Trust on purchasing decisions for Mandalika University Of Education students who use the Shopeeapplication. There is a simultaneous significant positive effect of discounts, promotions and consumer confidence on purchasing decisions for Mandalika University Of Educationn students who usethe Shopee applicationKeywords: Discount, Promotion, Consumer Confidence, e-commerce
MANAJEMEN STRES KERJA DI LEMBAGA PENDIDIKAN ISLAM
Authors: Saimima M Sahrawi , Ahyani Edi , Dhuhani Elfridawati Mai
Published: October 2023

Abstract (English): The worksystem built by all institutions of Islamic Education Institutions requires every employee and lecturer to work in order to provide excellent service to all stakeholders. With the improvement of good service, there is no doubt that employees or lecturers often feel stress in their work. This study aims to reveal the factors that cause work stress experienced by employees and lecturers at the Faculty of Tarbiyah Sciences and Teacher Training IAIN Ambon. The research method, which was used to streamline this research was to use qualitative research methods, with informants totaling six people selected based on work stress factors they often experienced. The results showed that several factors caused the stress experienced such as work pressure, work dedline, the number of applications, co-worker involvement, the use of elusive applications, and family. Then for his work stress management includes approaching himself to God, making work priority schedules, social support in this case colleagues and family, being firm in work, healing, eating a lot and also exercising.Keywords: Management; Work Stress; Islamic; Educational InstitutionsAbstrak (Indonesia): Sistem kerja yang dibangun oleh semua intitusi Lembaga Pendidikan Islam mengharuskan setiap pegawai dan dosennya untuk bekerja dalam rangka memberikan pelayanan yang prima kepada seluruh stakeholder. Dengan adanya peningkatan pelayanan yang baik, tak ayal para pegawai atau dosen sering merasakan stres dalam pekerjaannya. Penelitian ini bertujuan untuk mengungkapkan faktor penyebab stres kerja yang dialami oleh pegawai dan dosen di Fakultas Ilmu Tarbiyan dan Keguruan IAIN Ambon. Metode penelitian, yang digunakan untuk mengefektifkan penelitian ini adalah menggunakan metode penelitian kualitatif, dengan informan berjumlah enam orang yang dipilih berdasarkan faktor stres kerja yang sering mereka alami. Hasil penelitian menunjukan bahwa beberapa faktor penyebab stress yang dialami seperti tekanan pekerjaan, dedline pekerjaan, banyaknya aplikasi, keterlibatan rekan kerja, penggunaan aplikasi yang sukar dipahami, dan keluarga. Kemudian untuk manajemen stres kerjanya meliputi pendekatan diri kepada Allah, membuat jadwal prioritas kerja, dukungan sosial dalam hal ini rekan kerja dan keluarga, tegas dalam kerja, healing, banyak makan dan juga olahraga.  Kata Kunci : Manajemen; Stres Kerja; Islam; Lembaga Pendidikan
IMPLEMENTASI PROJEK KEWIRAUSAHAAN DALAM MENDUKUNG PROFIL PELAJAR PANCASILA DI SMAN 1 SIKUR
Authors: Hardiansyah Hardiansyah
Published: October 2023

Abstract: Pancasila Student Profile Entrepreneurship is able to realize idealistic dreams and develop their own potential with the emergence of 6 elements of the Pancasila Student Profile in Entrepreneurship Activities. The data analysis technique used in this study is descriptive qualitative data analysis using a qualitative triangulation model. The results of this study are the development of entrepreneurial projects in supporting the profile of Pancasila students in the form of the Merdeka curriculum which is modified into 1 program, the Entrepreneurship Project program where the program is scheduled on Fridays and Saturdays and the person in charge appears on a schedule that implements the learning process of entrepreneurship projects so as to develop talent in students and enthusiasm in creating a product, such as Typical Sasak Food, Typical Sasak Snacks (cakes), Candied Papaya, Efficacious Drinks, and Crafts. In the Entrepreneurship Project that supports the profile of Pancasila student profiles, SMAN 1 Sikur applies the independent curriculum (School of Mobilization), as it can encourage an entrepreneurial spirit through the Project to Strengthen Pancasila Student Profiles (P5) with the theme of entrepreneurship. Where the teacher of SMAN 1 Sikur hopes that with this the teacher becomes a facilitator and students must play an active role in the process or carry out activities in learning. Keywords: Entrepreneurship Project, Profile of Pancasila Supporters. Abstrak: Profil Pelajar Pancasila Kewirausahaan mampu mewujudkan mimpi idealisme dan mengembangkan potensi diri sendiri dengan munculnya 6 Elemen Profil Pelajar Pancasila dalam berkegiatan Kewirausahaan. Tehnik analisis data yang digunakan dalam penelitian ini yaitu analisis data kualitatif deskriptif dengan model Triangulasi kualitatif. Hasil penelitian ini diperoleh informasi dan data tentang implementasi projek kewirausahaan dalam mendukung profil pelajar pancasila dituangkan ke dalam Kurikulum Merdeka yang di modifikasi menjadi 1 program, program projek kewirausahaan yang dimana program itu disusun terjadwal pada hari Jum’at dan hari Sabtu dan muncul penanggung jawab secara terjadual itulah yang mengimplementasikan pada proses pembelajaran projek kewirausahaan sehingga mengembangkan bakat pada siswa dan semangat dalam menciptakan sebuah prodak, seperti Makanan Khas Sasak, Jajanan (kue) Khas Sasak, Manisan Pepaya, Minuman yang Berkhasiat dan Kerajiaan Tangan. Dalam Projek kewirausahaan yang mendukung profil pelajar pancasila SMAN 1 Sikur mengaplikasikan kurikulum merdeka (Sekolah Penggerak), sebagai dapat mendorong jiwa kewirausahaan melalui Projek Penguatan Profil Pelajar Pancasila (P5) tema kewirausahaan. Dimana guru SMAN 1 Sikur berharap dengan adanya hal tersebut guru menjadi fasilitator dan siswa yang harus berperan aktif dalam proses atau berkegiatan dalam pembelajaraan. Kata Kunci: Projek Kewirausahaan, Profil Pendukung Pancasila.
PERAN PENGAWAS PAI DALAM MENINGKATKAN KINERJA GURU PAI SD DI LOMBOK BARAT
Authors: Najwa Lu`luin
Published: October 2023

Abstract (English): This research was motivated by the lack of optimal supervision of West Lombok Elementary School PAI teachers. The purpose of this study is to describe PAI supervisors' role in improving PAI teachers' performance in elementary schools. The method used in this study is descriptive qualitative. The results showed that the role of PAI supervisors in improving teacher performance was carried out by 1) ensuring the implementation of the curriculum; 2) Supervise learning activities; 3) Provide guidance and supervision to teachers; 4) Monitor student progress; 5) Organizing training and workshops; 6) Coordinate with related parties; 7) Implement program evaluation and development; and 8) Maintain ethics and professionalism. Improving the performance of PAI teachers in elementary schools needs to pay attention to all aspects of supervision, supervision needs to be held on a scheduled basis by giving firmness to teachers to complete matters related to the implementation of learning.Key Words: Supervisor, teacher performance Abstrak (Indonesia):Penelitian ini dilatarbelakangi oleh belum optimalnya pengawasan terhadap guru PAI di SD Lombok Barat. Tujuan penelitian ini adalah untuk mendeskripsikan peran pengawas PAI dalam meningkatkan kinerja guru PAI di SD. Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif. Hasil penelitian menunjukkan bahwa peran pengawas PAI dalam Meningkatkan kinerja guru dilakukan dengan 1) memastikan pelaksanaan Kurikulum; 2) Mengawasi kegiatan pembelajaran; 3) Memberikan bimbingan dan supervisi kepada guru; 4) Memonitor perkembangan siswa; 5) Menyelenggarakan pelatihan dan workshop; 6) Berkoordinasi dengan pihak terkait; 7) Menerapkan evaluasi dan pengembangan program; dan 8) Menjaga etika dan profesionalisme. Peningkatan kinerja guru PAI di SD perlu memperhatikan segala aspek pengawasan, supervisi perlu diadakan terjadwal dengan memberikan ketegasan pada guru untuk melengkapi hal-hal yang bersangkutan dengan pelaksanaan pembelajaran.Kata Kunci: Pengawas, Kinerja Guru
PENGARUH KEDISIPLINAN GURU TERHADAP MOTIVASI BELAJAR PESERTA DIDIK DI SMP NEGERI 1 JEREWEH
Authors: Prihatin Umul Hani , Rahmawati Fitri , Afian Tilal
Published: October 2023

Abstract: This research aims to determine the influence of teacher discipline on students' learning motivation at SMPN 1 Jereweh. The type of research used in this research is quantitative descriptive. This research was carried out from April to May 2023 in class VIII at SMP Negeri 1 Jereweh, West Sumbawa Regency, for the 2022/2023 academic year. The population in this study were all class VIII students. The sample used in this research was class VIII D. The data collection technique was administering teacher discipline and student motivation questionnaires, interviews with school principals and subject teachers, and documentation. The data analysis technique was carried out using four grading scales for answers: very good was given a score of 4, good was given a score of 3, less good was given a score of 2, and not good was given a score of 1. The results of the research found that teacher discipline was influenced in learning activities in the excellent category, with a score of 50.1%. Students learning motivation is in a suitable category. The discipline of teachers at SMPN 1 Jereweh in student learning activities is suitable. Students' learning motivation, which is influenced by internal and external factors, is in the excellent category.Keywords: Teacher Discipline, Learning MotivationAbstrak: Penelitian ini bertujuan untuk mengetahui pengaruh kedisiplinan guru terhadap motivasi belajar peserta didik di SMPN 1 Jereweh. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif kuantitatif. Penelitian ini dilaksanakan dari Bulan April sampai Bulan Mei 2023 pada kelas VIII di SMP Negeri 1 Jereweh Kabupaten Sumbawa Barat Tahun Pelajaran 2022/2023. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII. Sampel yang di gunakan dalam penelitan ini adalah kelas VIII D. Teknik pengumpulan data yang digunakan melalui pemberian angket kedisiplinan guru dan motivasi peserta didik, wawancara dengan kepala sekolah dan guru mata pelajaran, dan dokumentasi. Teknik analisis data dilakukan dengan menggunakan 4 skala pemberian nilai dilakukan untuk jawaban sangat baik diberi nilai 4, baik diberi nilai 3, kurang baik diberi nilai 2, dan tidak baik diberi nilai 1. Hasil penelitian ditemukan adanya pengaruh kedisiplinan guru dalam kegiatan pembelajaran kategori baik dengan skor 50,1%. Motivasi belajar peserta didik masuk kategori baik. Dapat disimpulkan kedisiplinan guru di SMPN 1 Jereweh dalam kegiatan pembelajaran terhadap peserta didik masuk kategori baik. Motivasi belajar peserta didik yang dipengaruhi faktor internal dan eksternal masuk kategori baik.Kata Kunci: Kedisipilinan Guru, Motivasi Belajar
PENGARUH KONSELING TEKNIK ASSERTIVE TERHADAP KECEMASAN SOSIAL SOSIAL PADA SISWA KELAS XI IPS DI SMA NEGERI 1 JANAPRIA
Authors: Mardiana Yuni , Endriani Ani
Published: October 2023

Abstract: the purpose to be achieved in this study is to know the effect of assertive counseling techniques on social anxiety in Class XI IPS students in SMAN 1 Janapria. The data collection method used is questionnaire as the main method, observation, interview and documentation as a complementary method by using the design of one group pre-test and post-desigen test. In this study the study population was 80 students and 6 students who had high levels of social anxiety. Sampling techniques used are purposive samples and for data analysis using the T-test formula. Based on the results of data analysis, obtained t-count value of 8.531 with T-table value at the level of signitifikansi 5% with db (N-1) = 5 of 2.571. Thus the value of t-count is greater than the T-table (8.531 > 2.571) so that it can be concluded that there is an effect of assertive counseling techniques on social anxiety in Class XI IPS students in SMAN 1 Janapria, then the results of this study were declared “signitifikan”.Keywords: Assertive counseling techniques, social anxiety.Abstrak: Tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahmui pengaruh konseling teknik assertive terhadap kecemasan sosial pada siswa kelas XI IPS di SMAN 1 Janapria. Metode pengumpulan data yang digunakan adalah angket sebagai metode pokok, observasi, wawancara dan dokumentasi sebagai metode pelengkap dengan menggunakan rancangan one group pre-test and post-tes desigen. Dalam penelitian ini populasi penelitian berjumlah 80 siswa dan 6 siswa yang memiliki kecemasan sosial tingkat tinggi. Teknik sampling yang digunakan adalah purposive sampel dan untuk analisis data menggunakan rumus t-test. Berdasarkan hasil analisis data, diperoleh nilai  t-hitung sebesar 8,531 dengan nilai t-tabel pada taraf signitifikansi 5% dengan db (N-1) = 5 sebesar 2,571. Dengan demikian nilai t-hitung  lebih besar dari pada t-tabel (8,531 > 2,571) sehingga dapat ditarik kesimpulan bahwa ada pengaruh konseling teknik assertive terhadap kecemasan sosial pada siswa  kelas XI IPS di SMAN 1 Janapria, maka hasil penelitian ini dinyatakan “signitifikan”.Kata Kunci: Konseling Teknik Assertive, kecemasan sosial.
TINGKAT KEMAMPUAN BERPIKIR KREATIF SISWA DALAM MENYELESAIKAN SOAL TIPE HIGHER ORDER THINKING SKILL DI TINGKAT SMA
Authors: Widayanti Evi , Siahaan Jetti Oktavia
Published: October 2023

The aim of this research is to describe students' creative thinking abilities in solving Higher Order Thinking Skills type questions at the high school level. The type of research used by researchers is qualitative-descriptive research. The subjects in this research were Class XI students at SMA Wijaya Putra Surabaya. Meanwhile, to determine the object, the researcher used a sampling technique, namely purposive sampling, where the object was taken based on certain considerations. The data analysis technique that researchers will use is the Miles and Huberman model analysis technique. This model analysis technique is carried out interactively and continuously until the data is saturated. The steps that must be taken in this model analysis technique are data reduction, data presentation, and conclusions. The results of this research were that there were 25 subjects (90%) who were included in TKBK 0 (Not Creative). There are 3 subjects (10%) included in TKBK 1 (Less Creative). Students included in TKBK 1 are students who only meet one of the three indicators of creative thinking, namely fluency.
Ten years of climate change adaptation in Greenlandic fisheries: key observations from local ecological knowledge
Authors: Jacobsen RB , Dyremose SCS , Ounanian K , Raakjær J
Published: October 2023

This article reviews and examines the most significant climate-change-related impacts and adaptation from the perspective of stakeholders in Greenlandic fisheries. The study was constructed as a comprehensive, multi-site, bottom-up case study around Greenlandic fisheries (south-north/offshore-inshore), where interviews and workshops with Greenlandic fishers and stakeholders have communicated their observations of fishery changes associated with changes in the marine environment within the last decade. Key observations include: changes in sea ice cover; increased abundance of known species in North Greenland; fish species relocation and periodic absences in coastal systems; a northward movement of the shrimp fishery; new and unprecedented bycatch issues; and new fisheries. Stakeholder knowledge acknowledges the capacity of both offshore and coastal fisheries to adapt to changing seasonality and distribution. Factory capacity and decision-making as well as bycatch legislation have been identified as the most critical bottlenecks for (re)diversifying fisheries and increasing the value of the locally available resources.
DeepRaccess: high-speed RNA accessibility prediction using deep learning
Authors: Hara Kaisei , Iwano Natsuki , Fukunaga Tsukasa , Hamada Michiaki
Published: October 2023

RNA accessibility is a useful RNA secondary structural feature for predicting RNA-RNA interactions and translation efficiency in prokaryotes. However, conventional accessibility calculation tools, such as Raccess, are computationally expensive and require considerable computational time to perform transcriptome-scale analysis. In this study, we developed DeepRaccess, which predicts RNA accessibility based on deep learning methods. DeepRaccess was trained to take artificial RNA sequences as input and to predict the accessibility of these sequences as calculated by Raccess. Simulation and empirical dataset analyses showed that the accessibility predicted by DeepRaccess was highly correlated with the accessibility calculated by Raccess. In addition, we confirmed that DeepRaccess could predict protein abundance in E.coli with moderate accuracy from the sequences around the start codon. We also demonstrated that DeepRaccess achieved tens to hundreds of times software speed-up in a GPU environment. The source codes and the trained models of DeepRaccess are freely available at https://github.com/hmdlab/DeepRaccess.
Association of predicted body composition with occurrence of atrial fibrillation
Authors: Woo Ho Geol , Kang Min Kyoung , Song Tae-Jin
Published: October 2023

Background

Body mass index (BMI) is insufficient evidence as a risk factor for numerous health disorders. Body composition may be more appropriate for confirming the association with cardiovascular diseases, including atrial fibrillation (AF). This study aimed to examine the association between body composition and the occurrence of AF.

Methods

A total of 2,673,108 participants (48.6% women) without AF at baseline from the Korean national health insurance data were included. Body composition including appendicular skeletal muscle mass, body fat mass, and lean body mass were indirectly measured through validated anthropometric prediction equations. The diagnosis of AF and comorbidities were defined.

Results

With a median of 9.5 (interquartile range 9.2–10.1) years’ follow-up, 25,841 (0.96%) cases of incident AF were included. In multivariable analysis, higher appendicular skeletal muscle was related to low risk of AF [hazard ratio (HR) 0.829, 95% confidence interval (CI) 0.753–0.912 for men (fifth quintile) and HR 0.888, 95% CI 0.792–0.995 for women (fifth quintile)]. In contrast, a higher body fat mass [HR 1.345, 95% CI 1.221–1.483 for men (fifth quintile) and HR 1.420, 95% CI 1.274–1.591 for women (fifth quintile)] and lean body mass [HR 2.241, 95% CI 2.182–2.303 for men (fifth quintile) and HR 1.516, 95% CI 1.368–1.667 for women (fifth quintile)] were associated with the occurrence of AF.

Conclusions

In this study, body composition parameters were associated with the occurrence of AF. It should be noted that when appendicular skeletal muscle mass decreases and body fat mass and lean body mass increase, the risk of AF may be increased in general population except underweighted BMI group.
Assessing the impact of future climate scenarios on crop water requirements and agricultural water supply across different climatic zones of Pakistan
Authors: Shafeeque Muhammad , Bibi Amna
Published: October 2023

This study investigates the potential impacts of future climate change on crop water requirements (CWR) in different climatic zones of Pakistan and the subsequent implications for agricultural water demand and supply. Using the latest CMIP6 climate projections, we focused on Rabi and Kharif crop seasons, which are crucial for the growth of major crops in Pakistan. An empirical climate-crop and a hydrological model based on the Budyko theory were modified and forced to project future CWR changes and the potential widening of the water demand-supply gap until 2,100. Our results indicate a significant rise in mean annual CWR across all zones and emissions scenarios, with increasing rates at 2.30–2.57 mm/yr under SSP585 and 1.0–1.26 mm/yr under SSP245. Both Rabi and Kharif seasons show rising CWR, notably more under SSP585 (Kharif: 8%–14%, Rabi: 12%–15%) than SSP245 (Kharif: 4%–7%, Rabi: 6%–8%). The demand-supply gap is expected to grow notably, with arid and semi-arid zones being the most affected. Compared to 2015–2025, by 2091–2,100, the gap increased by 7%–15% (SSP245) and 15%–28% (SSP585) for Kharif and 7%–13% (SSP245) and 13%–32% (SSP585) for Rabi. To address these challenges, we recommend strategies like enhancing irrigation efficiency, adjusting crop patterns, and developing heat-resilient crops. Our insights aim to inform policy decisions on agriculture and water management in Pakistan under future climate change.
The relationship of hip fracture and thyroid disorders: a systematic review
Authors: SeyedAlinaghi SeyedAhmad , Yarmohammadi Soudabeh , Dashti Mohsen , Ghasemzadeh Afsaneh , Siami Haleh , Molla Ayoob , Mahrokhi Sona , Qaderi Kowsar , Arjmand Ghazal , Parikhani Sahar Nooralioghli , Amrollah Masoomeh Fathi , Mirghaderi Peyman , Mehraeen Esmaeil , Dadras Omid
Published: October 2023

Introduction

Bone density regulation is considered one of the systems affected by thyroid hormones, leading to low bone density that can result in pathologic fractures, including hip fractures. This review aimed to update clinicians and researchers about the current data regarding the relationship between hip fractures and thyroid disorders.

Methods

English papers were thoroughly searched in four main online databases of Scopus, Web of Science, PubMed, and Embase. Data extraction was done following two steps of screening/selection using distinct inclusion/exclusion criteria. This study used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist and the Newcastle-Ottawa Scale (NOS) as bias assessment.

Results

In total, 19 articles were included in the research. The risk of hip fractures in women with differentiated thyroid cancer (DTC) is higher than hip fractures caused by osteoporosis. Men with hyperthyroidism and subclinical hyperthyroidism are at higher risk for hip fracture. Also, a decrease in serum thyroid stimulating hormone (TSH) may be associated with an increased risk of hip fracture.

Conclusion

Reaching a consensus conclusion regarding the association between subclinical thyroid dysfunction and hip fracture is not feasible due to the heterogenicity of evidence; however, there may be a higher risk of fracture in individuals with subclinical hyperthyroidism.
The role of the junctional zone in the management of adenomyosis with infertility
Authors: Wang Sha , Duan Hua
Published: October 2023

The junctional zone (JZ) is an important structure in the myometrium that maintains uterine fertility. Changes in the junctional zone are closely related to infertility and adenomyosis (ADS). As an increasing number of young women are affected by ADS, the disease is no longer considered typical of women over 40. With these changes, an increasing number of patients refuse hysterectomy and desire fertility preservation treatment. At the same time, ADS is a crucial factor causing female infertility. Therefore, the treatment of ADS-related infertility and preservation of reproductive function is one of the other major challenges facing clinicians. For these young patients, preserving fertility and even promoting reproduction has become a new challenge. Therefore, we searched and summarized these studies on PubMed and Google Scholar using keywords such as “adenomyosis”, “junctional zone”, and “infertility” to explore infertility causes, diagnosis, and treatment of ADS patients who wish to preserve their uterus or fertility and become pregnant, focusing on the junctional zone, to obtain a full appreciation of the new perspective on this disease.
Help-seeking during 1-year follow-up in Chinese patients diagnosed with type 2 diabetes mellitus comorbid major depressive disorder
Authors: Geng Wenqi , Jiang Yinan , Hong Xia , Zhao Weigang , Ren Jie , Lloyd Cathy , Sartorius Norman , Wei Jing
Published: October 2023

Introduction

Previous research has revealed a bidirectional relationship between type 2 diabetes mellitus (T2DM) and major depressive disorder (MDD). A very limited proportion of patients with T2DM comorbid MDD received adequate psychiatric intervention. This study investigated the help-seeking behaviors of patients with T2DM comorbid with MDD during one-year follow-up.

Methods

At a medical center in China, a cohort of outpatients with T2DM were assessed and diagnosed for comorbid depression at baseline and after one year. The Mini International Neuropsychiatric Interview was used to diagnose MDD, while The Patient Health Questionnaire-9 (PHQ-9) and The Hamilton Depression Scale 17-item (HAMD-17) were used for depression assessment. Mental health help-seeking behaviors of patients during follow-up period were also evaluated.

Results

Out of the 203 patients with T2DM at baseline, 114 (56.2%) completed the follow-up. The prevalence of MDD in participants with T2DM was 12.8% at baseline and 22.8% at follow-up. Patients who completed the follow-up had a lower baseline PHQ-9 score (test statistic -2.068, p=0.039), HAMD-17 score (test statistic -2.285, p=0.022) than those who did not complete the follow-up. A total of 26 patients had comorbid MDD during the follow-up period, among which 8 patients (30.8%) voluntarily visited psychiatric clinics, while others did not seek assistance. The level of HbA1c at follow-up was higher in patients who sought help than in those who did not (8.1 ± 1.8% vs. 7.0 ± 0.7%), although the difference was not statistically significant.

Conclusion

Voluntary psychiatric help-seeking for Chinese patients with comorbid T2DM and MDD is uncommon. It is crucial to increase awareness of depression among patients and healthcare professionals alike.
Integrated transcriptomic and metabolomic analyses identify key factors in the vitellogenesis of juvenile Sichuan bream (Sinibrama taeniatus)
Authors: Zhao Zhe , Zhao Qiang , Wang Haoyu , Wei Lan , Wang Siya , Li Shilin , Yuan Dengyue , Wang Zhijian
Published: October 2023

Vitellogenesis is the most important stage of ovarian maturation in fish, involving the synthesis and transport of essential yolk substances and their complex mechanisms and coordination process. The liver is the main tissue involved in the vitellogenesis of oviparous animals, but studies of vitellogenesis in fish rarely include the liver and ovary as a whole. The aim of this study was to explore the molecular mechanism and associated regulatory factors behind vitellogenesis in Sichuan bream (Sinibrama taeniatus). The different stages of oogenesis were first identified by successive histological observations. Then, ovary and liver tissues that developed to 115 days (stage II, previtellogenesis stage), 165 days (stage III, vitellogenesis stage) and 185 days (stage IV, late-vitellogenesis stage) were collected for transcriptomic and metabolomic analyses, and serum testosterone (T), 17β-estradiol (E2), vitellogenin (Vtg), triiodothyronine (T3), and thyroxine (T4) levels were measured at the corresponding stages. We found that energy redistribution during vitellogenesis is mainly regulated through glycolysis, fatty acid biosynthesis and the citrate cycle pathway. In the liver, energy metabolism was promoted by activating glucolipid metabolic pathways to provide sufficient ATP, but at the same time, the ovary tends to retain nutrients rather than decompose them to produce energy. In addition, we have identified several key factors involved in the metabolism of neutral lipids, polar lipids, amino acids and vitamins, which are involved in the assembly and transport of important yolk nutrients. The initiation of vitellogenesis was found to be associated with a surge in serum E2 levels, but the sustained increase in Vtg levels in the late stage may be due more to upregulation of the estrogen receptor. These results provide valuable information about the regulation of ovarian development in cultured fish.
The influence of vegetation-generated turbulence on deposition in emergent canopies
Authors: Deitrick Autumn R. , Hovendon Erin H. , Ralston David K. , Nepf Heidi
Published: October 2023

Laboratory experiments measured sediment deposition and turbulent kinetic energy (TKE) in bare and vegetated channels. The model vegetation represented a mangrove pneumatophore canopy. Three solid volume fractions were considered (ϕ=  0.01, 0.02, and 0.04). For the same channel-averaged velocity, the vegetated region had elevated near-bed TKE compared to the bare region. Net deposition in both regions was measured by adding a sediment slurry of 11-micron solid glass spheres to the flume and collecting the deposited sediment from the flume baseboards after a 4-hr experiment. The elevated near-bed TKE in the vegetated region resulted in lower deposition compared to the bare region. A model for deposition probability written in terms of near-bed TKE (TKE model) more accurately predicted the measured deposition than a model based on bed shear stress (τb model). Application of the model to field conditions suggested that, by inhibiting deposition, vegetation-generated TKE facilitates the delivery of sediment farther into the mangrove forest than would be achieved without vegetation-generated TKE.
The Republic of Korea’s experience with an ocean dumping management system to enhance compliance with the London Protocol: highlights of major institutional history over 40 years
Authors: Kim Chang-Joon , Chung Chang Soo , Shin Kyung-Hoon , Choi Ki-Young
Published: October 2023

Since the late 1980s, in efforts to reduce the burden of waste treatment on land and to protect the nation’s rivers, the Korean government has licensed dumping at sea only for waste difficult to treat on land. However, owing to the “not in my backyard” (NIMBY) phenomenon and the higher cost of land-based treatment, the amount of ocean-dumped waste has increased rapidly. The categories of waste dumped have also expanded to include sewage sludge containing highly concentrated hazardous substances, raising concerns about damage to the marine environment. The Korean Ministry of Oceans and Fisheries has noted that compliance with the London Protocol could be essential for limiting ocean dumping activities. The Republic of Korea enacted comprehensive measures to ensure compliance and formally acceded to the London Protocol in 2009. This paper presents Korea’s implementation of the criteria that led to the cessation of ocean dumping of sewage sludge in 2016.
A hybrid energy-based and AI-based screening approach for the discovery of novel inhibitors of JAK3
Authors: Wei Juying , Pan Youlu , Shen Zheyuan , Shen Liteng , Xu Lei , Yu Wenjuan , Huang Wenhai
Published: October 2023

The JAKs protein family is composed of four isoforms, and JAK3 has been regarded as a druggable target for the development of drugs to treat various diseases, including hematologic tumors, cancer, and neuronal death. Therefore, the discovery of JAK3 inhibitors with novel scaffolds possesses the potential to provide additional options for drug development. This article presents a structure-based hybrid high-throughput virtual screening (HTVS) protocol as well as the DeepDock algorithm, which is based on geometric deep learning. These techniques were used to identify inhibitors of JAK3 with a novel sketch from a specific “In-house” database. Using molecular docking with varying precision, MM/GBSA, geometric deep learning scoring, and manual selection, 10 compounds were obtained for subsequent biological evaluation. One of these 10 compounds, compound 8, was found to have inhibitory potency against JAK3 and the MOLM-16 cell line, providing a valuable lead compound for further development of JAK3 inhibitors. To gain a better understanding of the interaction between compound 8 and JAK3, molecular dynamics (MD) simulations were conducted to provide more details on the binding conformation of compound 8 with JAK3 to guide the subsequent structure optimization. In this article, we achieved compound 8 with a novel sketch possessing inhibitory bioactivity against JAK3, and it would provide an acceptable “hit” for further structure optimization and modification to develop JAK3 inhibitors.
Community-based treatment of cutaneous leishmaniasis using cryotherapy and miltefosine in Southwest Ethiopia: the way forward?
Authors: van Henten Saskia , Pareyn Myrthe , Tadesse Dagimawie , Kassa Mekidim , Techane Mehret , Kinfe Eyerusalem , Girma Nigatu , Demeke Degnet , Mesay Mebratu , Kassa Mekibib , Temesgen Rodas , Shewangizaw Misgun , Massebo Fekadu , van Griensven Johan , Wegayehu Teklu , Merdekios Behailu
Published: October 2023

Background

Cutaneous leishmaniasis (CL) is a common, yet massively underreported skin morbidity in Ethiopia. Most patients never seek treatment, as this is offered only in specialized treatment centers. Early diagnosis and treatment through decentralization is crucial to decrease transmission and to reach the NTD roadmap goals. However, little information is available on outcomes and challenges of community-based treatment initiatives.

Methods

A community-based prospective cohort study was conducted in Ochollo. Patients with clinically or microscopy confirmed CL were included. Cryotherapy was (to be) given weekly with at least four sessions for uncomplicated lesions, and miltefosine was given for 4 weeks for complicated lesions. Miltefosine adherence was assessed by counting pill strips. Clinical and patient-reported outcomes (dermatological life quality index and patient-global assessment) were assessed at month 6 (M6).

Results

A total of 107 patients were included, with a median age of 6 years. Two patients refused, and 15 could not be treated as they were too young (<4 years) for miltefosine. Giving cryotherapy to patients weekly was not feasible due to long wound healing times and required use of topical antibiotics. Only 52.4% of miltefosine patients finished >90% of their tablets by M1. Among 46 patients treated with cryotherapy, 24 (52.2%) were cured at M6, and 9 (19.6%) had substantial improvement. The cure rate was 16/39 (41.0%) for miltefosine with 28.2% (11/39) substantial improvement. Before treatment, more than half (57.8%) of patients reported that CL did not negatively impact their life, which significantly increased to 95.2% at M6. At this time, 61.7% of patients said their lesion was clear, which was 1% before treatment.

Conclusion

Our study is the first to identify the challenges and opportunities of miltefosine and cryotherapy for community treatment of CL. Although overall cure rates were lower than expected, patient-reported outcomes were generally positive and quite some patients had good improvement.