bluuebunny/crossref_metadata_2025 huggingface dataset:
Essential Topics for the Regulatory Consideration of Phages as Clinically Valuable Therapeutic Agents: A Perspective from Spain
Authors: Vázquez Roberto , Díez-Martínez Roberto , Domingo-Calap Pilar , García Pedro , Gutiérrez Diana , Muniesa Maite , Ruiz-Ruigómez María , Sanjuán Rafael , Tomás María , Tormo-Mas María Ángeles , García Pilar
Published: March 2022

Antibiotic resistance is one of the major challenges that humankind shall face in the short term. (Bacterio)phage therapy is a valuable therapeutic alternative to antibiotics and, although the concept is almost as old as the discovery of phages, its wide application was hindered in the West by the discovery and development of antibiotics in the mid-twentieth century. However, research on phage therapy is currently experiencing a renaissance due to the antimicrobial resistance problem. Some countries are already adopting new ad hoc regulations to favor the short-term implantation of phage therapy in clinical practice. In this regard, the Phage Therapy Work Group from FAGOMA (Spanish Network of Bacteriophages and Transducing Elements) recently contacted the Spanish Drugs and Medical Devices Agency (AEMPS) to promote the regulation of phage therapy in Spain. As a result, FAGOMA was asked to provide a general view on key issues regarding phage therapy legislation. This review comes as the culmination of the FAGOMA initiative and aims at appropriately informing the regulatory debate on phage therapy.
Management of a Major Carbapenem-Resistant Acinetobacter baumannii Outbreak in a French Intensive Care Unit While Maintaining Its Capacity Unaltered
Authors: Risser Clémence , Pottecher Julien , Launoy Anne , Ursenbach Axel , Belotti Laure , Boyer Pierre , Willemain Rosalie , Lavigne Thierry , Deboscker Stéphanie
Published: March 2022

We describe bundle measures implemented to overcome a protracted carbapenem-resistant Acinetobacter baumannii (CRAB) outbreak in an 18-bed trauma Intensive Care Unit (ICU) at Strasbourg University Hospital, a tertiary referral center in France. Outbreak cases were defined by a positive CRAB sample with OXA-23 profile during or after ICU say. To sustain the capacity of the busy trauma ICU, infection control bundles were purposely selected to control the outbreak without closing the ICU. During the outbreak, from May 2015 to January 2019, 141 patients were contaminated by CRAB, including 91 colonized and 50 infected patients. The conventional infection and prevention control (IPC) measures implemented included weekly active surveillance of patients’ samples, enhancement of environmental cleaning, interventions to improve hand hygiene compliance and antibiotic stewardship with audits. Supplemental measures were needed, including environmental samplings, health care workers’ (HCWs) hand sampling, chlorhexidine body-washing, relocation of the service to implement Airborne Disinfection System (ADS), replication of crisis cells, replacement of big environmental elements and improvement of HCW organization at the patient’s bedside. The final measure was the cohorting of both CRAB patients and HCW caring for them. Only the simultaneous implementation of aggressive and complementary measures made it possible to overcome this long-lasting CRAB epidemic. Facing many CRAB cases during a rapidly spreading outbreak, combining simultaneous aggressive and complementary measures (including strict patients and HCW cohorting), was the only way to curb the epidemic while maintaining ICU capacity.
Fruit Peels as a Sustainable Waste for the Biosorption of Heavy Metals in Wastewater: A Review
Authors: Gómez-Aguilar Dora Luz , Rodríguez-Miranda Juan Pablo , Salcedo-Parra Octavio José
Published: March 2022

One of the environmental challenges that is currently negatively affecting the ecosystem is the continuous discharge of untreated industrial waste into both water sources and soils. For this reason, one of the objectives of this qualitative study of exploratory-descriptive scope was the review of scientific articles in different databases—Scopus, Web of Science, and Science Direct—published from 2010 to 2021 on the use of fruit peels as a sustainable waste in the removal of heavy metals present in industrial wastewater. For the selection of articles, the authors used the PRISMA guide as a basis, with which 210 publications were found and 93 were compiled. Considering the reported work, a content analysis was carried out using NVivo 12 Plus and VOSviewer 1.6.17 software. The results show that the fruits mentioned in these publications are lemon, banana, mango, tree tomato, pineapple, passion fruit, orange, coconut, avocado, apple, lulo, and tangerine. However, no studies were found with lulo and tree tomato peels. On the other hand, the heavy metals removed with the selected fruit peels were Pb+2, Cr+3, Cr+6, Ni+2, Cd+2, As+5, Cu+2, and Zn+2.
Determination of Menbutone: Development and Validation of a Sensitive HPLC Assay according to the European Medicines Agency Guideline
Authors: López Cristina , Díez Raquel , Rodríguez José M. , Sierra Matilde , García Juan J. , Fernández Nélida , Diez M. José , Sahagún Ana M.
Published: March 2022

Menbutone is often used to stimulate the hepato-digestive activity in case of digestive disorders and hepatic insufficiency in different species (cattle, sheep, goats, pigs, horses, dogs) because it has choleretic and cholagogue effects and increases gastric and pancreatic juices. The objective was to develop and validate an HPLC method to quantify menbutone in sheep plasma using sparfloxacin as internal standard. The HPLC mobile phase consisted of acetonitrile:monopotassium phosphate solution. The method was validated according to EMA guideline (EMEA/CHMP/EWP/192217/2009). Mean retention times of menbutone and sparfloxacin were 4.5 and 2.2 min, respectively. The method met all specifications of the EMA guideline, being selective and linear in the range of 0.2–100 µg/mL (R2 ≥ 0.99). The within-run precision range was 0.19–8.21%, with an accuracy of 102.99–119.52% for the lower limit of quantitation (LLOQ). For the other values (LOW, MED, HIGH) the precision range was 0.01–4.77%, with an accuracy of 85.17–109.67%. The LLOQ was 0.2 µg/mL, and no interference from the biological matrix was found. Stability of menbutone in the biological matrix at different storage conditions was also demonstrated. Thus, the method can be used to determine menbutone concentrations in plasma sheep in different types of studies.
A Multiobjective Optimization Approach for Retrofitting Decision-Making towards Achieving Net-Zero Energy Districts: A Numerical Case Study in a Tropical Climate
Authors: Chacón Lorena , Chen Austin Miguel , Castaño Carmen
Published: March 2022

Buildings are among the main reasons for the deterioration of the world environment as they are responsible for a large percentage of CO2 emissions related to energy. For this reason, it is necessary to find solutions to this problem. This research project consists of constructing the metamodel of an urbanization located in Panama, Herrera province. The classification and systematization of its main elements, using the software DesignBuilder and SysML diagrams, were carried out for its subsequent implementation in an optimization analysis that seeks to approach the NZED standard. The main objectives of the optimization are reducing the energy consumption at the lowest possible price while maintaining or improving thermal comfort. In this study, it was possible to reduce electricity consumption to at least 60% of the original value and about 10% of the renewable energy generation capacity by implementing optimization techniques within the retrofit category related to the envelope of the buildings and the occupant’s behavior.
Efficiently Mitigating Face-Swap-Attacks: Compressed-PRNU Verification with Sub-Zones
Authors: Hassani Ali , Malik Hafiz , Diedrich Jon
Published: March 2022

Face-swap-attacks (FSAs) are a new threat to face recognition systems. FSAs are essentially imperceptible replay-attacks using an injection device and generative networks. By placing the device between the camera and computer device, attackers can present any face as desired. This is particularly potent as it also maintains liveliness features, as it is a sophisticated alternation of a real person, and as it can go undetected by traditional anti-spoofing methods. To address FSAs, this research proposes a noise-verification framework. Even the best generative networks today leave alteration traces in the photo-response noise profile; these are detected by doing a comparison of challenge images against the camera enrollment. This research also introduces compression and sub-zone analysis for efficiency. Benchmarking with open-source tampering-detection algorithms shows the proposed compressed-PRNU verification robustly verifies facial-image authenticity while being significantly faster. This demonstrates a novel efficiency for mitigating face-swap-attacks, including denial-of-service attacks.
Trends in the development of the banking system of the Republic of Uzbekistan and expert-analytical assessments of the effectiveness of the functioning of its banking sector entities
Authors: Fadeikina N. ..
Published: March 2022

In order to substantiate the trends in the development of the banking system of the Republic of Uzbekistan and its banking sector, the institutional support of the mechanisms for implementing the Strategy for Reforming the Banking System of the Republic of Uzbekistan for 2020-2025 and the Strategy «Digital Uzbekistan - 2030» is evaluated. Special attention is paid to the transformation of the unitary enterprise «National Bank for Foreign Economic Affairs of the Republic of Uzbekistan» into a joint-stock company (JSC «NBU»), the privatization of banking sector entities in 2021-2025, as well as the modernization of banking services and digital transformation of the activities of commercial banks of the republic. The issues related to the implementation of the main directions of these strategies in the context of the ongoing coronacrisis, which has had a significant impact on the functioning of the banking sector and the entire national economy of the republic, are considered. The article summarizes expert and analytical assessments of the financial stability and efficiency of the banking sector entities of the Republic of Uzbekistan for 2019-2020, including those obtained by the expert community based on the results of indexing the activity of banks, carried out in the rating format using the CAMELS model indicator system.
Assessment of the efficiency of state financial control
Authors: Kapriyan Yu. ..
Published: March 2022

The article examines the theoretical and methodological aspects and problems of assessing the effectiveness of state financial control, studied by many scientists as the main tool for managing public entities and financial resources of the Republic of Moldova. The author highlights the components of assessing the effectiveness of state bodies, characterizing both the effectiveness of the implementation of state policy and the effectiveness of the use of budgetary funds and the work of civil servants. The article also emphasizes the need for controlling as a system to ensure effective management of public entities and financial resources.
About poverty as one of the global problems of mankind and about the policy to overcome it
Authors: Naumenko A. .. , Shapovalova A. ..
Published: March 2022

The article examines some of the causes of poverty in society. It is concluded that without solving this large-scale problem, it is impossible to achieve socio-economic development of the state, poverty is a brake on development. Having long been one of the global problems of mankind, poverty has resumed its growth in recent years; partly as a result of global isolation caused by the coronacrisis, a factor that sharply reduces economic activity in many sectors of the world economy and has a negative impact on the livelihoods of households.
Economic development of Norway and Sweden. Why is Russia not Norway?
Authors: Arefyev P. ..
Published: March 2022

The article analyzes the causes and features of the economic development of Norway and Sweden, their differences, and common features. The author considers these problems using statistical data as a basis. The relevance of the article emphasizes the consideration of the impact of the SARS-CoV-2 virus on the economies of Norway and Sweden, their measures to protect citizens and results. The article is informative, it can be used to compare the considered Scandinavian states with Russia and determine the differences between the countries.
On the question of factors and indicators poverty in Russia
Authors: Naumenko A. . , Shapovalova A. .
Published: March 2022

This article examines the dynamics of real monetary incomes of the population, as well as the level of poverty in Russia; it is proved that minor increases in the minimum wage do not lead to an increase in real incomes, as they are «eaten up» by inflation; it is shown that the minimum wage should be tied to a real increase in prices for essential goods and services based on objective statistical data. It is emphasized that the subsistence minimum and the minimum wage, being basic social indicators, are among the indicators that determine the poverty threshold.
External economic sanctions in the international space: historical background and modern realities
Authors: Polyanskaya I. . , Pospelov A. . , Yakushov A. .
Published: March 2022

This article provides a brief historical background of the sanctions events in the international arena, provides an overview of the sanctions policy against Russia, assesses the positive and negative aspects of the bans imposed and considers a set of anti-Russian sanctions. The relevance of the topic is due to the tension of political relations between Russia and Western countries. The generalization prepared by the authors makes it possible to systematize knowledge on the issues under consideration and may be of interest to domestic and foreign scientists studying external economic sanctions in legal, historical, political and economic aspects.
Is netrin-1 a reliable inflammatory marker for periodontitis?
Authors: Abdulfattah Sarah Yasser , Baiomy Azza Abdel Baky , Youssef Jilan Mohammed
Published: March 2022

Background. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease. Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group. Results. Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (P<0.05). Conclusion. Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.
Comparing two equations for estimation of kidney function (Cockcroft-Gault and Glomerular Filtration Rate Assessment in Liver Disease) for vancomycin dosing in adult liver transplant recipients: a pilot, randomized clinical trial
Authors: Saee Yasaman , Dashti-Khavidaki Simin , Ahmadinejad Zahra , Ghiasvand Fereshteh
Published: March 2022

Background: In the setting of impaired liver function, estimation of glomerular filtration rate (GFR) using common creatinine-based equations is inaccurate. Recently, the Glomerular filtration Rate Assessment In Liver disease (GRAIL) model has been introduced to estimate GFR in liver transplantation. This study was conducted to compare vancomycin dose adjustment in liver transplant patients using Cockcroft-Gault (C-G) versus the GRAIL method. Methods: In this pilot, randomized clinical trial, adult liver transplant recipients who were a candidate to receive intravenous vancomycin were enrolled. The level of kidney function was estimated using the GRAIL model and C-G equation in the intervention and control arms, respectively. Then, vancomycin maintenance doses were accordingly adjusted. At the steady state, peak and trough serum concentrations of vancomycin were collected for area under the concentration-time curve (AUC) calculation and pharmacokinetic comparisons. Results: Fifteen patients were enrolled in each arm of study. The mean daily dose of vancomycin was estimated insignificantly lower for individuals in the GRAIL arm than the C-G group (1550.00±544.45 versus 1750.00± 389.60mg). Compared with the C-G group, a higher rate of patients in the GRAIL arm experienced below-target vancomycin trough concentrations (40.0% versus 13.3%), and a lower rate showed above target trough concentration (40.0% versus 66.7%). These differences did not reach statistical significance. Individuals in the GRAIL arm represented significantly higher rate of below target vancomycin AUC/MIC than patients in the C-G arm (46.7% versus 6.7%) (P=0.049). No differences in clinical outcomes were observed between the two groups. Conclusion: Using the GRAIL model for vancomycin dosing may result in less percent of patients with at target AUC/MIC compared to the C-G method and expose more patients at risk for vancomycin under dosing.
Andrographolide and epigallocatechin gallate (EGCG) lower the risk of addiction induced by nicotine and cigarette smoke extract (CSE) in mice
Authors: Samirah Samirah , Indrayanti Kurnia , Nurhan Ahmad Dzulfikri , Softyana Vida , Pradipta Nadya Ratri , Ardianto Chrismawan , Yulistiani Yulistiani , Rahmadi Mahardian
Published: March 2022

Background: Nicotine, a psychoactive compound from the tobacco plant, produces a reward effect that potentially causes addiction. It is postulated that nicotine addiction occurs through increased reactive oxygen species production in nucleus accumbens, which causes damage to the endogenous antioxidant defense system resulting in an increased need for nicotine intake, which leads to addiction. The antioxidants, andrographolide and epigallocatechin gallate (EGCG), are expected as potential substances to decrease the risk of nicotine addiction. This study aimed to analyze the effect of andrographolide and EGCG on the risk of addiction induced by nicotine and cigarette smoke extract (CSE) in mice. Methods: Thirty-five Balb/c male mice, divided into seven groups, were used in this study. The administered drugs were normal saline 1.0 mL/kg BW as control group, nicotine 0.5 mg/kg BW, CSE 1.0 mg/kg BW, andrographolide 50 mg/kg BW, and EGCG 50 mg/kg BW as pre-treatment. Conditioned place preference (CPP) with a biased design method was used to evaluate the reward effects induced by nicotine and CSE. Several stages were carried out, namely pre-conditioning, conditioning, post-conditioning, extinction, and reinstatement tests. Results: Based on the CPP score, both nicotine (p<0.001) and CSE (p<0.001) groups increased the reward effect significantly compared to that of the normal saline group. The andrographolide + nicotine (p<0.001) and EGCG + nicotine (p<0.001) groups decreased the reward effect significantly compared to that of the nicotine group without pharmacological treatment. Similarly, the andrographolide + CSE (p<0.001) and EGCG + CSE (p<0.01) groups decreased the reward effect significantly compared to that of the CSE group without pharmacological treatment. Conclusions: Andrographolide and EGCG lower the risk of addiction induced by nicotine and CSE.
Preventive effects of Spirulina platensis on exercise-induced muscle damage, oxidative stress and inflammation in taekwondo athletes: a randomized cross-over trial
Authors: Kashani Arvin , Keshavarz Seyed Ali , Jafari-Vayghan Hamed , Azam Kamal , Hozoori Mohammad , Alinavaz Mina , Djafarian Kurosh
Published: March 2022

Abstract Background: Spirulina is an interesting nutritional supplement that has attracted a lot of attention. The aim of the present study was to examine the effect of spirulina supplementation on oxidative stress, inflammatory factors and plasma markers of exercise-induced muscle damage in male taekwondo athletes. Results: A total of 18 trained taekwondo male athletes took part in a double-blind, placebo-controlled crossover study. Each subject received either spirulina (8 g/day) or placebo for 3 weeks. The study had two periods separated by a 14-day washout. Blood samples were taken after finishing a training checklist program (4 times in total). There were no significant carryover effects; therefore, the two-week washout period was adequate. Compared to the placebo, a dose of 8 g / d of spirulina supplement over 21 days resulted in a significant decrease in plasma levels of lactate dehydrogenase (LDH), creatine kinase (CK) and interleukin 6 (IL6) and a significant increase in plasma levels of total antioxidant capacity (TAC), superoxide dismutase (SOD) and glutathione peroxidase (GPX) (p<0.05). There was not any statistically significant change in the plasma malondialdehyde (MDA) (p>0.05). Conclusion: Due to the improvement of antioxidant and anti-inflammatory conditions as well as an appropriate protein content, spirulina supplementation can produce a preventive effect on exercise-induced muscle damage in taekwondo athletes. Trial registration: Iranian Registry of Clinical Trials, IRCT20121110011421N4. Registered 12 July 2021 - Retrospectively registered, https://irct.ir/trial/11692.
The effects of interprofessional education on teamwork, communication skills and quality of health care in advanced and developing countries: A systematic review and meta-analysis study
Authors: Asvadi Kermani Atabak , Ghojazadeh Morteza , Hazrati Hakime , Alizadeh Mahasti
Published: March 2022

Background: Inter-professional education is a new approach in education in which professionals in various fields of health systems learn from each other based on educational events in a real environment, actively and interactively. This systematic review and metaanalysis aims to investigate inter-professional education in advanced and developing countries. Methods: Persian and English keywords were used to search these databases: ISI Web of Science, Scopus, ProQuest, PubMed/Medline, Embase, Google Scholar, ERIC, Magiran, Irandoc, and Barakat with an English language restriction and for the years 2000 to 2019, using these terms: Embase, Meshand and free. Two evaluators assessed the extracted articles using the Critical Appraisal Skills Program (CASP) checklist. CMA 3.1 software was used for the analysis with a fixed-effects model. Results: A total of 1425 articles formed the basis of this study. In all, nine articles were extracted that examined the effect of inter-professional education from the viewpoints of professors and students (three for professors and six for students). Heterogeneity among the nine studies was not significant. Teamwork scores, communication skills, and healing of the participants in the study increased by 0.339, 0.283, and 0.275 points after the intervention, respectively. Conclusion: Inter-professional education is one method of educational integration. Students become aware of how their role overlaps with other medical professions as well as the limitations of their role in treating patients. However, inter-professional education implementation requires infrastructure, such as training professors and preparing them and students to accept inter-professional education.
Dental Status and Changes in the Levels of Secondary Antioxidants in the Oral Fluid during Pathology of the Oral Mucosa in Patients with Diseases of the Gastrointestinal Tract in the Dynamics of Treatment
Authors: Ахадова П.Д.
Published: March 2022

Был обследован 21 пациент с патологией слизистой оболочки полости рта (СОПР) и заболеваниями желудочно-кишечного тракта. Лечение проведено в 2 группах пациентов: 1-я группа (n=9) получала базисную терапию, 2-я группа (n=12) – базисное лечение и локально β-аминокапроновую кислоту. Контрольную группу (n=10) составили практически здоровые лица. Стоматологическое обследование показало, что индекс КПУ был повышен в большей мере за счет компонента «П». Индекс РМА до лечения в 1,4–1,6 раза был выше, чем в группе практически здоровых лиц. Гигиенический индекс РНР был повышен в группах пациентов в 2 раза. У пациентов до лечения выявлено снижение уровней вторичных антиоксидантов (альбумин на 36,5%, билирубин на 61,4%) и азотосодержащих антиоксидантов (мочевина на 11,8%, мочевая кислота на 15,8%). В результате комплексной терапии с β-аминокапроновой кислотой отмечалось статистически значимое повышение уровней антиоксидантов неферментативной системы (альбумин на 27,3%, мочевина на 8,9%, мочевая кислота на 11,5% и билирубин на 30,9%).

21 patients with pathology of the oral mucosa and diseases of the gastrointestinal tract were checked-up. Treatment was conducted in 2 groups of patients: 1-st group (n=9) received basistherapy, 2-nd group (n=12) – basis therapy and locally β-aminocaproic acid. Control group (n=10) composed practically healthy people. Dental check-up showed that KPU index was increased mainly due to the component "P". Index PMA before treatment was in 1.4–1.6 higher, than at the practically healthy people group. Hygiene index PHP was increased in both groups twice. In patients before treatment was revealed the decrease of secondary antioxidants level (albumen on 36.5%, bilirubin on 61.4%) and nitrogen containing antioxidants (urea on 11.8%, uric acid on 15.8%). At the result of complex therapy with β-aminocaproic acid, noted statistically significant increase of non-enzymatic system antioxidants levels (albumen on 27.3%, urea on 8.9%, uric acid on 11.5% and bilirubin on 30.9%).
Planning of Restorations in Aesthetic Stomatology
Authors: Луцкая И.К. , Новак Н.В.
Published: March 2022

Представлены новые критерии по планированию и оценке эстетических реставраций. В статье описаны этапы изготовления упроченного адгезивного протеза. Представлен клинический случай изготовления адгезивной волоконной конструкции при отсутствии центрального резца.

New criteria for planning and evaluation of aesthetic restoration are presented. In article fabrication stages of the strengthened adhesive artificial limb are described. The clinical case of production adhesive fiber designs in the absence of the central cutter is presented.
Women's Economic Empowerment: Paving the Way for Household Income Enhancement
Authors: Sahari Noorul Huda , Alias Baterah , Aris Suliah Mohd , Samori Zakiah , Harun Nur Hafizah
Published: March 2022

Objective – Women with careers nowadays play an important role in their household income to support breadwinner
husbands in easing the financial burden of families. To achieve the role, women are empowered to be independent and
not too dependent on others by handing over the duty to generate a family income solely to their husbands. With low
physical, financial, and human capital, and limited social and economic networks in Pulau Tuba, Langkawi, when the
socio-economy activities of its majority Muslim population depend on agriculture, aquaculture, and tourism, the
activities should be expanded to potential activities to increase family income since the island is well known with its
natural resources. Women on the island also identify less participate in increasing the family income. Thus, this study
aims to identify the potential activities for family income upgrading and determine factors for women's empowerment
to support family income and the success of the activities.
Methodology – To achieve the objective the study adopts quantitative research where the data were collected through a
survey to randomly selected 150 respondents out of 4350 Pulau Tuba total population. The questionnaires are
distributed to respondents through face to face by the representatives of the research team in November 2020. The
collected data has been analyzed by descriptive, correlation, and regression analysis using Statistical Package for The
Social Science (SPPS) tool version 21.
Findings – The finding shows that women in Pulau Tuba are more inclined to increase their daily and family income in
marketing, sales, livestock, and fisheries. Moving on, the environmental factor is the most effective because of its
higher correlation value than the family factor and environmental factors that contribute significantly to improving
family income in Pulau Tuba. Therefore, it is suggested to put effort to enhance awareness among women through
appropriate workshops on marketing with large-scale participation.
Type of Paper: Empirical
JEL Classification: O11, O4
Ortaöğretime Devam Eden Öğrencilerde Problemli İnternet Kullanımının Akademik Güdülenmeye Etkisi
Authors: AKBABA Taner , KAYA Metin
Published: March 2022

Bu araştırmanın amacı ortaöğretime devam eden öğrencilerde problemli internet kullanımının akademik güdülenmeye etkisini incelemektir. Araştırmada problemli internet kullanımı ve akademik güdülenme arasındaki ilişkiyi incelemek amacıyla ilişkisel tarama modeli kullanılmıştır. Araştırmanın örneklemini 2017-2018 eğitim öğretim yılı Erzurum ili Merkez İlçelerinde bulunan Fen Lisesi, Sosyal Bilimler Lisesi ve Anadolu Liselerine devam eden 360 kız öğrenci ve 280 erkek öğrenci olmak üzere toplam 640 öğrenci oluşturmuştur. Araştırmada veri toplama aracı olarak ortaöğretime devam eden öğrenciler için araştırmacı tarafından tasarlanan kişisel bilgi formu, problemli internet kullanım ölçeği-ergen ve akademik güdülenme ölçeği kullanılmıştır. Araştırmanın uygulanması sürecinde elde edilen veriler yapısal eşitlik modeli (YEM) ile analiz edilmiştir. Araştırmanın analizleri LISREL 8.80 ve SPSS 21.00 programları aracılığıyla yapılmıştır. Araştırma sonucunda problemli internet kullanımı ve akademik güdülenme ölçeklerinin alt boyutları arasında negatif yönde anlamlı ilişkiler olduğu, problemli internet kullanımının akademik güdülenmeyi negatif düzeyde anlamlı olarak yordadığı sonucuna ulaşılmıştır.
Ortaokul Öğrencilerinin Yakın Çevreye Yönelik Farkındalıklarının Sınıf Düzeyleri Açısından Karşılaştırılması
Authors: HÜSEYİNBAŞ Özgür , ÜNAL Ahmet , YERLİKAYA Zekeriya
Published: March 2022

Bu çalışmanın amacı, Kastamonu ilinde yaşayan ortaokul öğrencilerin içinde yaşadıkları yakın çevredeki canlı ve cansız çeşitliliğine yönelik farkındalıklarını ortaya koymak ve bu farkındalık durumlarını sınıf düzeylerine göre karşılaştırmaktır. Bu kapsamda, bu araştırmada uygulanmak üzere “Yakın Çevre Farkındalık Testi” geliştirilmiştir ve araştırmada nicel araştırma türlerinden tarama modeli kullanılmıştır. Kastamonu il ve ilçelerinde yaşayan toplam 720 ortaokul öğrencisinin yakın çevreye yönelik farkındalıkları farklı değişkenler bakımından irdelenmiştir. Elde edilen bulgular analiz edildiğinde öğrencilerin yakın çevre ve canlılara yönelik farkındalıklarının oldukça düşük olduğu sonucuna ulaşılmıştır. Bu çalışmada elde edilen sonuçların ve önerilerin değerlendirilmesi halinde, bu alanla ilgili eğitim-öğretim faaliyetlerinde verimliliği artırma noktasında katkı verebileceği düşünülmüştür.
Okul Öncesi Öğretmenlerinin Okul Dışı Öğrenme Ortamlarını Kullanma Durumlarının Değerlendirilmesi
Authors: YILDIZ Ensar
Published: March 2022

Okul öncesi öğretmenlerinin okul dışı öğrenme ortamlarını kullanma durumlarını değerlendirmek amacıyla yapılan bu çalışmada karma araştırma yöntemlerinden açımlayıcı sıralı desen kullanılmıştır. Çalışma grubu 135 öğretmenden oluşmaktadır. Araştırmanın verileri “Okul Öncesi Öğretmenlerinin Okul Dışı Öğrenme Ortamlarına Yönelik Görüş Anketi” ve “Okul Öncesi Öğretmenlerinin Okul Dışı Öğrenme Ortamlarını Kullanma Durumlarının Belirlenmesine İlişkin Yarı Yapılandırılmış Görüşme Formu” ile toplanmıştır. Nicel verilerin analizinde frekans ve yüzde hesaplanırken, nitel verilerin analizinde Maxqda programıyla içerik analizi yapılmıştır. Çalışma grubunda yer alan öğretmenlerin okul dışı öğrenme ortamlarının kullanımı ile ilgili bilgi düzeylerinin yetersiz olduğu bulunmuştur. Öğretmenlerin eğitim etkinliklerini gerçekleştirirken en çok sınıf içi öğrenme ortamlarını kullandıkları belirlenmiştir. Maddi olanakların ve ulaşım imkânlarının yetersizliği, sınıf yönetiminin zorluğu, iklim koşullarının elverişsizliği ve ailelerin izin vermemesinden dolayı öğretmenlerin okul dışı öğrenme ortamlarını daha az kullandığı sonucuna ulaşılmıştır.
SISTEM PENUNJANG KEPUTUSAN SELEKSI BEASISWA BERDASARKAN MULTI KRITERIA DENGAN METODE PROFILE MATCHING DAN WEIGHTED PRODUCT (WP) BERBASIS WEB PADA PERUSAHAAN PERBANKAN
Authors: Murdianto Bayu , Utama Gunawan Pria
Published: March 2022

Abstrak

Bank Mandiri merupakan perusahaan yang bergerak di bidang perbankan. PT. Bank Mandiri berdiri pada tanggal 2 Oktober 1998, sebagai bagian dari program restrukturisasi perbankan yang dilaksanakan pada pemerintah Indonesia.Tahun 2015 merupakan tahun yang penting bagi Bank Mandiri karena bertepatan dengan dimulainya Transformasi Tahap III 2015-2020, sehingga kinerja Bank Mandiri di 2015 akan menjadi barometer dan landasan dalam menghadapi serta menyelesaikan tantangan yang lebih besar pada tahun-tahun mendatang. Untuk membangun Indonesia lebih cerdas dan lebih pintar PT. Bank Mandiri membuat program beasiswa untuk meningkatkakan siswa/siswi lebih cerdas dan lebih pintar. PT. Bank Mandiri mempunyai program beasiswa untuk siswa/siswi SMA berprestasi yang akan melanjutkan pendidikan ke bangku kuliah. PT. Bank Mandiri belum memiliki sistem khusus untuk penerimaan beasiswa agar proses penerimaan beasiswa mendapakan hasil yang objektif dan efektif. Dengan studi kasus ini penulis menggunakan Metode Profile Matching dan Metode Weighted Product (WP). Dari hasil penelitian ini PT.Bank Mandiri Bisa Mendapatkan Siswa yang berprestasi dengan tepat dan akurat.
IMPLEMENTASI ALGORITMA KRIPTOGRAFI RC4 UNTUK KEAMANAN DATABASE APLIKASI PENGGAJIAN KARYAWAN BERBASIS WEB PADA PT. TRANS INTRA ASIA
Authors: Setiawan Andre , Fatimah Titin
Published: March 2022

Trans Intra Asia adalah perusahaan yang bergerak di bidang consultant management yang mempuyai 70 karyawan. Setiap bulannya Perusahaan melakukan penggajian terhadap karyawan dimana data yang disimpan dalam database yang memiliki keamanan mudah dicuri karena hanya memakai keamanan database yang sewaktu–waktu bisa saja dicuri atau digunakan oleh pihak yang tidak bertanggung jawab. Jadi perlu dibuat aplikasi keamanan database untuk mengamankan data penggajian karyawan. Teknik kriptografi menjadi salah satu solusi yang perlu digunakan untuk pengamanan database. Adapun metode kriptografi yang digunakan algoritma RC4 (Rivest Code 4) yang termasuk kunci simetris, yaitu kriptografi yang menggunakan kunci enkripsi yang sama dengan dekripsinya. Kelebihan kriptografi kunci simetris adalah proses enkripsi dan dekripsi membutuhkan waktu yang cukup singkat, untuk ukuran kunci simetris relatif lebih pendek dan dapat dipergunakan untuk membangkitkan bilangan acak. Aplikasi ini menggunakan bahasa pemrograman PHP (Hypertext Prepocessor) dengan database MySQL. Hasil penelitian ini menunjukkan data penggajian karyawan pada  perusahaan dapat terjaga kerahasiaannya karena menggunakan proses enkripsi lebih dahulu sehingga data penggjian lebih aman dan terhindar dari pencurian data atau digunakan oleh pihak tidak bertanggung jawab.
IMPLEMENTASI STEGANOGRAFI LEAST SIGNIFICANT BIT (LSB) PADA APLIKASI BERBASIS DESKTOP DI PENGEMBANG PROPERTI BSA LAND
Authors: Marudin Marudin , Windarto Windarto
Published: March 2022

BSA Land merupakan pengembang properti yang berkomitmen dalam pengembangan perumahan, area bisnis dan pasar segar. BSA Land, dalam proses produksi perencanaan menghasilkan gambar-gambar yang bersifat penting, diantaranya Masterplan, Siteplan dan Artist Impression. Gambar-gambar tersebut tidak diperkenankan untuk disebarluaskan sebelum menjadi media publikasi seperti brosur, baliho dan banner, sehingga perlu diamankan. Dengan berperkembangan nya teknologi informasi, keamanan dalam penyimpanan dan pengiriman data sangat diperlukan demi menjaga kerahasiaan data tersebut. Salah satu cara mengamankan data rahasia tersebut adalah dengan menggunakan teknik steganografi. Pada tahap pembangunan aplikasi ini menggunakan bahasa pemrograman java. Data yang dapat di encode berupa gambar berformat (*.png). Berdasarkan hasil uji coba yang dilakukan pada aplikasi ini menggunakan metode Steganografi Least Significant Bit (LSB) rata-rata hasil encode pada penelitian ini adalah 5242880 Byte, rata-rata hasil decode adalah 1061795,84 Byte. Proses encode pada penelitian ini rata-rata membutuhkan waktu 120322.5 Milidetik, Sedangkan rata-rata proses decode file membutuhkan waktu 13506.75 Milidetik.
ROLE OF MRI IN EVALUATION OF TRAUMATIC KNEE INJURIES AMONG ADULTS; SEE YOUR KNEE BY AN EYE OF A RADIOLOGIST.
Authors: Kumar Ravi , Deshpande Anagha Vaidya , D. Sonawane Bhawana
Published: March 2022

Introduction: Magnetic Resonance Imaging (MRI) as a non-invasive imaging modality plays a vital role in assessment of a wide spectrum of
internal knee derangements. The objective of this study is to characterise the pattern of internal derangement of knee joint using MRI, and
determines the patient management.
Method: This study is a tertiary care hospital based prospective diagnostic study which was conducted in the Department of Radio diagnosis,
Indira Gandhi Government Medical College and Hospital, Nagpur. This study was conducted over 90 patients who were referred from various
referral centres. First Magnetic resonance imaging (MRI) knee was performed and then these patients underwent Arthroscopy. MRI images are
studied for evidence of injuries to the cruciate, menisci ligaments, collateral ligaments, tendons around the knee joint, uid collections, bony
contusions and soft tissue injuries.
Results: Out of 90 cases 71 are males 19 are females. Left knee is commonly involved accounting for 55 cases. Right knee is involved in 15 cases.
Young patients are maximum in number who suffered from knee injuries which predominantly comprises age group of 21 to 40 years. The most
common complaint of patients is pain and instability. Anterior cruciate ligament (ACL) injury is the most common injury followed by Medial
meniscus injury.
Interpretation And Conclusion: MRI is an extremely useful imaging modality for evaluation of knee injuries. It gives valuable information to the
referring orthopaedician for planning the line of treatment in terms of conservative management or surgery.it is very accurate in detecting both intra
and extra articular injuries.
“A STUDY TO EVALUATE THE EFFECTIVENESS OF SELF-INSTRUCTIONAL MODULE ON KNOWLEDGE REGARDING MATERNAL HEALTH BENEFITS AMONG ANTENATAL MOTHERS IN SELECTED RURAL AREAS, TUMKUR.”
Authors: S Eswarappa , M S Balaji , C Dayanand , Rani R Shilpa
Published: March 2022

Introduction: Maternal and child health refers to the promotive, preventive and curative and rehabilitative care of mothers and children. Antenatal
1 care is the care of women during pregnancy the main aim of care is to achieve at the end if a pregnancy healthy mother and healthy baby. Most of the
Antenatal mothers don't know about the Different maternal health benets scheme. Providing knowledge about the maternal health benets
scheme helps to live a better-quality life.The aim of the study was to nd the effectiveness of Self-Instructional Module (SIM) on the knowledge
regarding Maternal health benet schemes among antenatal mothers. Methods: An evaluative approach with pre-experimental one group pre-test
post-test design was used with purposive sampling technique to select the sample (N=50). A structured knowledge questionnaire was used to assess
the Knowledge and SIM was administered to nd its effectiveness. The collected data was analyzed by using Descriptive statistics like mean,
median and standard deviation, and inferential statistics like paired and independent 't' test was included to test the hypothesis and Chi-square test
was included to test the association of knowledge scores with demographic variables. Results: The mean percentage of post-test knowledge score
(79.1 %) was higher than the mean percentage of pre-test knowledge score (46.5%). The calculated' value [t (49) = 52.39] is greater than the table
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value (0.05, 49df) = 1.96. It showed a signicant difference between mean pre- and post- test knowledge scores. The calculated χ values for age
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group, type of family, educational status, family income per month, Gravida of the mother were more than the table value and calculated χ values
were less than the table values for Source of information with their post-test knowledge scores. Interpretation & Conclusion: The ndings of the
study showed that there was a decit in knowledge of Antenatal mothers before administration of SIM. The results indicated that the SIM is
effective in increasing the knowledge of Antenatal mothers on Maternal health benet schemes.
A RARE CASE OF SICKEL CELL DISEASE (SCD) MOYA MOYA SYNDROME : CASE REPORT
Authors: Shaikh Shahid , Kumari Purnima , Patel Ankur
Published: March 2022

BACKGROUND: Moyamoya syndrome (MMS) is a relatively uncommon vascular complication of sickle cell disease (SCD) characterized by
progressive stenosis of the supraclinoid carotid arteries and development of typical collaterals. MMS confers a signicant lifetime risk of ischemic
stroke, and frequently results in multiple cerebrovascular events leading to poor outcomes. Management of MMS in this population is challenging.
Ischemic stroke develops in 7% to 11% of children with homozygous sickle cell anemia (HbSS)
CLINICAL DESCRIPTION: We present a case of Moyamoya syndrome disease that was detected in a 7-year-old female who presented with
transient altered mental status &leftsided hemiparesis. On MR angiography and further investigation, the child was diagnosed to have Moyamoya
diseases with sickle cell disease.
MANAGEMENT: Although there is no denitive medicaltreatment, numerous direct and indirect revascularization procedures have been used
to improve the compromisedcerebral circulation, with outcomes varying according to procedure type, the treatment goal is toimprove blood ow to
hypoperfused cerebral regions bysurgery. Our patient was treated conservatively and referred to a higher Centre for specic neurosurgery.
Neurosurgical revascularization process leads to favorable outcome.
CONCLUSION: Moyamoya disease can be diagnosed if history, physical exam and brain imaging is highly suspicious. Conventional
angiography remains the gold standard for diagnosis and aids in surgical planning for patients with suspected Moyamoya disease
EFFECT OF CLAY THERAPY AND FREE EXERCISE FOR REDUCTION OF ANXIETY IN GERIATRICS- AN EXPERIMENTAL STUDY
Authors: Oza Helly , Solanki Vidhya
Published: March 2022

Geriatic medicine is a specially categorized that focuses on health care of elderly people. It helps in preventing and treating diseases and disabilities
in older adults. Nowadays, anxiety, depression and stress are very common in adults and in geriatrics. Anxiety is one type of felling of uneasiness
and worry, which is generalized as an overreaction to any situation. Anxiety is closely related to fear which is response to a real or immediate
situation. Clay is a very known material known from prehistoric time in forms such as vases, pots and symbolic gure. Clay therapy involves an
intense and powerful tactile experience of touching. Clay therapy having evidence of reduction of anxiety and gave benecial result and free
exercise also having evidence of reduction of anxiety .Combination of these two treatment gives remarkable result on reduction of anxiety in
geriatric people. The aim of study is to reduce anxiety in old AIM: OBJECTIVE: age people. The objective of the study is to educate the
patient about anxiety and to nd out whether clay therapy and free exercise are effective in reduction of anxiety in geriatric. An STUDY DESIGN:
Experimental Study in highlight In 6 weeks of intervention; 30 participants with fe METHODS: atures of anxiety were studied. They will be
collected by convenience sampling. Pre and post data is collected and analyzed using SPSS 26.0. A signicant improvement is seen in RESULTS:
anxiety (p‹0.05) after the treatment was found. Greater statistical signicant improvement was seen in geriatic. The study CONCLUSION:
concluded that clay therapy and free exercise is effective in reduction of anxiety for geriatric.
EFFECT OF VARMAN THERAPY ON UTHIRAVATHASURONITHAM (RHEUMATOID ARTHRITIS) – A CASE REPORT
Authors: Sathya Sindhuja Bhuvanagiri , Sankar Injarapu , Tiwari Shweta , Anam Anam
Published: March 2022

A36-year-old male from Tarnaka,visited with the chief complaints of pain,severe stiffness, and restricted range of movement of shoulderjoints,
ankle joints and interphalangeal joints of upper limb in both active and passive movements.He was diagnosed case ofRheumatoid Arthritis which
can be equated toUthiravathasuronitham, one of the Vatha disease mentioned in Siddhasystem of medicine. The disease varies greatly in the
manner and degree to which it may affect a patient's general health, mobility and quality of life. Patient was treated with the Siddha Varman Therapy
for 23 days. After 23 sessions of therapy reduction in pain, and restricted movement with the improvement in quality of life were measured by using
the Visual Analog Scale (VAS)andHealth Assessment Questionnaire- Disability Index (HAQ-DI) respectively.
CLINICO RADIOLOGICAL CORRELATION IN COVID-19 PATIENTS.
Authors: Rekha Bokam Bhanu , Puvvadi Sireesha , Lakshmi K.charan
Published: March 2022

INTRODUCTION: Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by a novel coronavirus, known as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 genome is similar to that of SARS and Middle East respiratory syndrome.
Infection by COVID-19 can result in a range of clinical outcomes, from asymptomatic to severe life-threatening course or death. Most of the
1
affected patients present with high temperature and dry cough
Chest radiograph (CXR) played a role in determining the course and the severity of disease during the 2002 severe acute respiratory syndrome
2
(SARS) and the 2012 Middle East respiratory syndrome (MERS) outbreaks
The diagnostic armamentarium of COVID-19 is inclusive of travel history, history of exposure, clinical features, and reverse
transcriptase–polymerase chain reaction (RT-PCR) assay from specimens obtained by oropharyngeal or nasopharyngeal swab, assisted with
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digital Chest radiograph (CXR)
AIMS & OBJECTIVES:
1.To Study clinical correlation to chest x ray in covid 19 patients.
2.To Study clinical correlation to outcome in covid 19 patients.
METHODS & MATERIALS: This is a prospective study which included 507 patients with laboratory-conrmed COVID-19 admitted in
tertiary care hospital from May 2020 to Nov 2020. The patients were examined clinically , were assessed for signs& symptoms and severity of
pneumonia. All patients underwent a digital CXR examination.
RESULTS: Out of 507 patients studied, 58.6% were males, 41.4%were females.Most of the affected patients are between 41-60 yrs of age group
.Death percentage is more in critical group compared to noncritical group.Our observational study shows signicant correlation between clinical
features , CXR and outcome in covid 19 patients.