bluuebunny/crossref_metadata_2025 huggingface dataset:
Types of naming errors in chronic post-stroke aphasia are dissociated by dual stream axonal loss
Authors: McKinnon Emilie T. , Fridriksson Julius , Basilakos Alexandra , Hickok Gregory , Hillis Argye E. , Spampinato M. Vittoria , Gleichgerrcht Ezequiel , Rorden Chris , Jensen Jens H. , Helpern Joseph A. , Bonilha Leonardo
Published: September 2018

The types of errors during speech production can vary across individuals with chronic post-stroke aphasia, possibly due to the location and extent of brain damage. In this study, we evaluated the relationship between semantic vs. phonemic errors during confrontational naming, and their relationship with the degree of damage to ventral and dorsal white matter pathways extending beyond the necrotic stroke lesion. Based on the dual stream model of language processing, we tested the hypothesis that semantic errors would be associated with ventral stream damage, whereas phonemic errors would be associated with dorsal stream damage, but not vice-versa. Multi-shell diffusion MRI was used to obtain kurtosis-based white matter tractography from 32 chronic stroke survivors. Using diffusion microstructural tissue modeling, we estimated axonal loss along the length of the inferior and superior longitudinal fasciculi (ILF and SLF), representing the main pathways in the ventral and dorsal streams, respectively. The frequency of semantic paraphasias was strongly associated with ILF axonal loss, whereas phonemic paraphasias were strongly associated with SLF axonal loss, but not vice versa. This dissociation between semantic and phonological processing is in agreement with the dual stream model of language processing and corroborates the concept that, during speech production, knowledge association (semantics) depends on the integrity of ventral, whereas form encoding (phonological encoding) is more localized to dorsal pathways. These findings also demonstrate the importance of the residual integrity of specific white matter pathways beyond regional gray matter damage for speech production.
Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells
Authors: Plackal Adimuriyil George Blassan , Kumar Neeraj , Abrahamse Heidi , Ray Suprakas Sinha
Published: September 2018

Metallic nanoparticles (NPs) especially silver (Ag) NPs have shown immense potential in medical applications due to their distinctive physio-chemical and biological properties. This article reports the conjugation of Ag NPs with Rubus fairholmianus extract. The modification of Ag NPs was confirmed using various physico-chemical characterization techniques. The cytotoxic effect of Rubus-conjugated Ag NPs (RAgNPs) was studied by LDH assay and proliferation by ATP assay. The apoptotic inducing ability of the NPs were investigated by Annexin V/PI staining, caspase 3/7 analysis, cytochrome c release, intracellular ROS analysis, Hoechst staining and mitochondrial membrane potential analysis using flow cytometry. The expression of apoptotic proteins caspase 3, Bax and P53 were analyzed using ELISA and caspase 3, Bax using western blotting. Cells treated with 10 µg/mL RAgNPs showed an increased number of cell death by microscopic analysis compared to untreated control cells. The RAgNPs induced a statistically significant dose-dependent decrease in proliferation (p < 0.001 for 5 and 10 µg/mL) and increased cytotoxicity in MCF-7 cells. A 1.83 fold increase in cytotoxicity was observed in cells treated with 10 µg/mL (p < 0.05) compared to the untreated cells. Nuclear damage and intracellular ROS production were observed upon treatment with all tested concentrations of RAgNPs and the highest concentrations (5 and 10 µg/mL) showed significant (p < 0.05, p < 0.01) expression of caspase 3, Bax and P53 proteins. The data strongly suggest that RAgNPs induces cell death in MCF-7 cells through the mitochondrial-mediated intrinsic apoptosis pathway. The present investigation supports the potential of RAgNPs in anticancer drug development.
Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification
Authors: Jiang Kewu , Tang Zan , Li Juan , Wang Fengchao , Tang Nan
Published: September 2018

Genetic studies have shown that FGF10/FGFR2 signaling is required for airway branching morphogenesis and FGF10 functions as a chemoattractant factor for distal epithelial cells during lung development. However, the detail downstream cellular and molecular mechanisms have not been fully characterized. Using live imaging of ex vivo cultured lungs, we found that tip airway epithelial progenitor cells migrate faster than cleft cells during airway bud formation and this migration process is controlled by FGFR2-mediated ERK1/2 signaling. Additionally, we found that airway progenitor cells that migrate faster tend to become distal airway progenitor cells. We identified that Anxa4 is a downstream target of ERK1/2 signaling. Anxa4−/− airway epithelial cells exhibit a “lag-behind” behavior and tend to stay at the stalk airways. Moreover, we found that Anxa4-overexpressing cells tend to migrate to the bud tips. Finally, we demonstrated that Anxa4 functions redundantly with Anxa1 and Anxa6 in regulating endoderm budding process. Our study demonstrates that ERK1/2/Anxa4 signaling plays a role in promoting the migration of airway epithelial progenitor cells to distal airway tips and ensuring their distal cell fate.
Omega-3 from Flaxseed Oil Protects Obese Mice Against Diabetic Retinopathy Through GPR120 Receptor
Authors: Dátilo Marcella Neves , Sant’Ana Marcella Ramos , Formigari Guilherme Pedron , Rodrigues Patrícia Brito , de Moura Leandro Pereira , da Silva Adelino Sanchez Ramos , Ropelle Eduardo Rochete , Pauli José Rodrigo , Cintra Dennys Esper
Published: September 2018

The chronic and low-grade inflammation induced by obesity seem to be the “first hit” to retinopathy associated to diabetes type 2. Herein, we hypothesized that omega-3 fatty acids from flaxseed oil enriched diet disrupt the pro-inflammatory status in the retina, protecting against retinopathy development. For eight weeks under a high-fat diet (HF), several physiological parameters were monitored to follow the metabolic homeostasis disruption. After this period, mice were treated with a HF substituted in part of lard by flaxseed oil (FS) for another eight weeks. Food behavior, weight gain, glucose and insulin sensitivity, electroretinography, RT-qPCR and western blots were carried out. The HF was able to induce a pro-inflammatory background in the retina, changing IL1β and TNFα. VEGF, a master piece of retinopathy, had early onset increased also induced by HF. The FS-diet was able to decrease inflammation and retinopathy and improved retinal electro stimuli compared to HF group. GPR120 and GPR40 (G Protein-Coupled Receptors 120 and 40), an omega-3 fatty acid receptors, were detected in the retina for the first time. FS-diet modulated the gene expression and protein content of these receptors. Thus, unsaturated fatty acids protect the retina from diabetes type 2 mice model from disease progression.
Age-Structured Population Modeling of HPV-related Cervical Cancer in Texas and US
Authors: Peng Ho-Lan , Tam Samantha , Xu Li , Dahlstrom Kristina R. , Wu Chi-Fang , Fu Shuangshuang , Zhong Chengxue , Chan Wenyaw , Sturgis Erich M. , Ramondetta Lois , Rong Libin , Lairson David R. , Miao Hongyu
Published: September 2018

Human papillomavirus (HPV)–related cervical cancer is a major public health threat to women, with >10,000 new cases diagnosed annually in the United States between 2008 and 2012. Since HPV vaccines can protect against ~80% of HPV-associated cervical cancers, the economic and epidemiological impacts of HPV vaccination have been extensively investigated, particularly at the national level. However, vaccination policies are state-specific, and state-level models are required for state-specific policy decisions. This study adapted an age-structured population model to describe the dynamics of HPV-related cervical cancer in Texas, with model parameters calibrated for Texas. The Year 2000 parameter set was the start point, and the model’s predictions from 2001–2010 were well matched with the real incidence numbers in 23 age groups, suggesting the validity of the model. Application of the model to the Year 2010 parameter set predicted that, over the next 10 decades, incidence would decrease rapidly within the first decade and more slowly thereafter. Sensitivity analysis determined the impact of selected parameters (e.g., vaccine coverage rate) on future disease incidence. When compared with the US parameter sets, the Texas population was more sensitive to changes in HPV transmission and vaccination (e.g., ~8% difference in the predicted disease decline).
Persister Cells – a Plausible Outcome of Neutral Coevolutionary Drift
Authors: Khlebodarova T. M. , Likhoshvai V. A.
Published: September 2018

The phenomenon of bacterial persistence – a non-inherited antibiotic tolerance in a minute fraction of the bacterial population, was observed more than 70 years ago. Nowadays, it is suggested that “persister cells” undergo an alternative scenario of the cell cycle; however, pathways involved in its emergence are still not identified. We present a mathematically grounded scenario of such possibility. We have determined that population drift in the space of multiple neutrally coupled mutations, which we called “neutrally coupled co-evolution” (NCCE), leads to increased dynamic complexity of bacterial populations via appearance of cells capable of carrying out a single cell cycle in two or more alternative ways and that universal properties of the coupled transcription-translation system underlie this phenotypic multiplicity. According to our hypothesis, modern persister cells have derived from such cells and regulatory mechanisms that govern the consolidation of this phenomenon represented the trigger. We assume that the described type of neutrally coupled co-evolution could play an important role in the origin of extremophiles, both in bacteria and archaea.
Impedance Spectroscopy as a Novel Approach to Probe the Phase Transition and Microstructures Existing in CS:PEO Based Blend Electrolytes
Authors: Aziz Shujahadeen B. , Faraj M. G. , Abdullah Omed Gh.
Published: September 2018

In this work the role of phase transition of PEO from crystalline to amorphous phases on DC conductivity enhancement in chitosan-based polymer electrolyte was discussed. Silver ion-conducting polymer electrolytes based on chitosan (CS) incorporated with silver nitrate (AgNt) is prepared via solution cast technique. Various amounts of polyethylene oxide (PEO) are added to the CS:AgNt system to prepare blend polymer electrolytes. Ultraviolet-visible (UV-vis) spectrophotometry is used to confirm that the blended samples containing AgNt salt exhibit a broad absorption peak. From optical micrograph images it is apparent that small white specs appear on the surface of the samples. The SEM results clearly show the aggregated silver nanoparticles. The enlargement of the crystalline area was observed from the morphological emergence and impedance plots. The phase separation in SEM images was observed at high PEO concentration. The XRD consequences support the morphological manifestation. In this study a new approach is offered to explore the microstructures existing in the blend electrolytes. The width of the semicircle linked to crystalline phase in impedance spectra was found to be increased with the increase of PEO concentration. A slow increase of DC conductivity was observed at low temperatures while above 333 K an immediate change in DC conductivity was obtained. The rapid rise of DC conductivity at high temperatures is correlated with the DSC results and impedance studies at high temperatures.
CRISPR-Cas9 ribonucleoprotein-mediated co-editing and counterselection in the rice blast fungus
Authors: Foster Andrew J. , Martin-Urdiroz Magdalena , Yan Xia , Wright Harriet Sabrina , Soanes Darren M. , Talbot Nicholas J.
Published: September 2018

The rice blast fungus Magnaporthe oryzae is the most serious pathogen of cultivated rice and a significant threat to global food security. To accelerate targeted mutation and specific genome editing in this species, we have developed a rapid plasmid-free CRISPR-Cas9-based genome editing method. We show that stable expression of Cas9 is highly toxic to M. oryzae. However efficient gene editing can be achieved by transient introduction of purified Cas9 pre-complexed to RNA guides to form ribonucleoproteins (RNPs). When used in combination with oligonucleotide or PCR-generated donor DNAs, generation of strains with specific base pair edits, in-locus gene replacements, or multiple gene edits, is very rapid and straightforward. We demonstrate a co-editing strategy for the creation of single nucleotide changes at specific loci. Additionally, we report a novel counterselection strategy which allows creation of precisely edited fungal strains that contain no foreign DNA and are completely isogenic to the wild type. Together, these developments represent a scalable improvement in the precision and speed of genetic manipulation in M. oryzae and are likely to be broadly applicable to other fungal species.
Response of macrophages and neural cells in contact with reduced graphene oxide microfibers
Authors: Serrano M. C. , Feito M. J. , González-Mayorga A. , Diez-Orejas R. , Matesanz M. C. , Portolés M. T.
Published: September 2018

rGO microfibers mediate polarization of RAW-264.7 macrophages towards an M2 phenotype and support neural progenitor cell growth.
Binding of halogens by a Cr8 metallacrown
Authors: Sava Daniel Florin , Zheng Nan , Vitórica-Yrezábal Iñigo J. , Timco Grigore A. , Winpenny Richard E. P.
Published: September 2018

A Cr8 metallacrown binds halogens X2 (Cl2, Br2 and I2) without loss of crystallinity; the binding has been studied by X-ray diffraction and thermodynamic techniques.
A series of new hybrid selenidostannates with metal complexes prepared in alkylol amines
Authors: Luo Hai-Ying , Zhou Jian
Published: September 2018

A series of new hybrid selenidostannates were synthesized in alkylol amines, whose zinc selenidostannate with a photocurrent response represents the first example of the hybrid chalcogenidostannate incorporating rare tetrahedral metal complexes.
Theoretical insight on ethylene polymerization catalyzed by carborane-containing metal complexes: the role of carborane
Authors: Ma Nana , Wei Changgeng , Li Shujun , Zhang Guisheng
Published: September 2018

Theoretical calculations indicate carborane rather than Cp* plays a decisive role in ethylene polymerization catalyzed by carborane-containing metal complexes.
Copper(i) sulfide: a two-dimensional semiconductor with superior oxidation resistance and high carrier mobility
Authors: Guo Yu , Wu Qisheng , Li Yunhai , Lu Ning , Mao Keke , Bai Yizhen , Zhao Jijun , Wang Jinlan , Zeng Xiao Cheng
Published: September 2018

δ-Cu2S sheets are energetically favorable, and exhibit superior oxidation resistance, suitable direct band gap, and ultrahigh carrier mobility.
Magnetic field-oriented ferroferric oxide/poly(2,6-dimethyl-1,4-phenylene oxide) hybrid membranes for anion exchange membrane applications
Authors: Chen Nanjun , Wang Dong , Long Chuan , Li Yunxi , Lu Chuanrui , Wang Fanghui , Zhu Hong
Published: September 2018

A magnetic-field-oriented hybrid membrane constructs successive and effective QA-Fe3O4 ion channels to improve the comprehensive performance.
Influence of polymeric electrets on the performance of derived hybrid perovskite-based photo-memory devices
Authors: Ercan Ender , Chen Jung-Yao , Shih Chien-Chung , Chueh Chu-Chen , Chen Wen-Chang
Published: September 2018

The influence of polymer matrix selection on photo-response and memory properties of the derived hybrid perovskite-based photo-memory devices was investigated.
d-/l-Isothymidine incorporation in the core sequence of aptamer BC15 enhanced its binding affinity to the hnRNP A1 protein
Authors: Li Liyu , Yang Xiantao , Li Kunfeng , Zhang Guangpu , Ma Yuan , Cai Baobin , Li Shaohua , Ding Hongmei , Deng Jiali , Nan Xiyan , Sun Jing , Wu Yun , Shao Ningsheng , Zhang Lihe , Yang Zhenjun
Published: September 2018

Truncation of BC15 and d-/l-isothymidine modification of its core sequence greatly enhanced the binding affinity and selectivity to the hnRNP A1 protein.
Synthesis of near-infrared fluorescent rhodamines via an SNArH reaction and their biological applications
Authors: Wang Qing , Huang Kun , Cai Songtao , Liu Chang , Jiao Xiaojie , He Song , Zhao Liancheng , Zeng Xianshun
Published: September 2018

Seven rectilinearly π-extended NIR fluorescent rhodamines were synthesized via an intramolecular SNArH reaction under mild conditions without any transition metal catalyst or extra oxidant.
Catalytic asymmetric Tamura cycloaddition of homophthalic anhydrides with 2-arylidene-1,3-diones
Authors: Xu Han , Sha Feng , Li Qiong , Wu Xin-Yan
Published: September 2018

2-Arylidene-1,3-diones have been firstly employed in enantioselective Tamura cycloaddition to construct chiral spiro-1,3-indanedione derivatives.
Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation
Authors: Hu Miao , Gao Yang , Wu Wanqing , Li Jianxiao , Li Chunsheng , Zhang Hao , Jiang Huanfeng
Published: September 2018

A convenient and efficient strategy to construct functionalized ynones by a palladium-catalyzed cascade annulation reaction has been developed.
Influence of shell compositions of solution blown PVP/PCL core–shell fibers on drug release and cell growth
Authors: Chan Park Seok , Kim Min Jung , Choi Kyoungju , Kim Jooyoun , Choi Seong-O
Published: September 2018

The presence of hydrophilic porogens on the surface of core–shell fibers can accelerate drug release and enhance cell proliferation.
High responsivity and 1/f noise of an ultraviolet photodetector based on Ni doped ZnO nanoparticles
Authors: Ben Elkamel Imen , Hamdaoui Nejeh , Mezni Amine , Ajjel Ridha , Beji Lotfi
Published: September 2018

This study involves the novel fabrication of a high responsivity, fast response, and low-cost (UV) photodetector (PD) based on ZnO/Ni nanoparticles deposited on a glass substrate.
Chemistry of black leaf films synthesised using rail steels and their influence on the low friction mechanism
Authors: Ishizaka Kei , Lewis Stephen R. , Hammond Deborah , Lewis Roger
Published: September 2018

Graphite-like carbon was found to be formed by leaf organics and rail steels, causing low friction between wheels and rails.
A simple strategy for converting starch to novel compressible carbonaceous foam: mechanism, enlightenment and potential application
Authors: Lei Hong , Wu Yao , Yang Sen , Fu Chunfang , Huo Jichuan
Published: September 2018

The conversion mechanism from starch to carbonaceous foam provides inspiration for the conversion of other biomass into value-added carbonaceous materials.
Crystal structures, and magnetic and thermal properties of basic copper formates with two-dimensional triangular-lattice magnetic networks
Authors: Fujita Wataru
Published: September 2018

Basic copper formate, [Cu3(OH)4(HCOO)2], has a distorted two-dimensional triangular lattice magnetic network and showed antiferromagnetic ordering at 2.15 K.
Phase separation around a heated colloid in bulk and under confinement
Authors: Roy Sutapa , Maciołek Anna
Published: September 2018

Temperature gradient influences the coarsening patterns of a binary solvent around a heated colloid; under confinement a bridge forms connecting the colloid and the walls.
Chitosan/rectorite nanocomposite with injectable functionality for skin hemostasis
Authors: Li Xiaoyun , Li Yi-Chen , Chen Mingjie , Shi Qingshan , Sun Runcang , Wang Xiaoying
Published: September 2018

Maltose-like chitosan/rectorite nanocomposites could promote blood coagulation and reduce the release of clay particles to avoid in vitro secondary thrombosis.
A highly efficient bactericidal surface based on the co-capture function and photodynamic sterilization
Authors: Huang Lin , Liu Xin-Hua , Zhang Xiao-Hong , Tan Lei , Liu Chuan-Jun
Published: September 2018

Bacterial infection is posing a great threat to human life, and constructing a platform to capture or kill the bacteria attached on a material surface is of particular significance.
A programmable and biomimetic photo-actuator: a composite of a photo-liquefiable azobenzene derivative and commercial plastic film
Authors: Hu Jing , Li Xiao , Ni Yue , Ma Shudeng , Yu Haifeng
Published: September 2018

A programmable and biomimetic bilayer actuator enabled by a photo-liquefiable azobenzene derivative.
The potential role of MGMT rs12917 polymorphism in cancer risk: an updated pooling analysis with 21010 cases and 34018 controls
Authors: Sheng Zhiguo , Kang Meini , Wang Hao
Published: September 2018

In the present study, we aimed at determining the potential role of rs12917 polymorphism of the O-6-methylguanine-DNA methyltransferase (MGMT) gene in the occurrence of cancer. Based on the available data from the online database, we performed an updated meta-analysis. We retrieved 537 articles from our database research and finally selected a total of 54 case–control studies (21010 cases and 34018 controls) for a series of pooling analyses. We observed an enhanced risk in cancer cases compared with controls, using the genetic models T/T compared with C/C (P-value of association test <0.001; odds ratio (OR) = 1.29) and T/T compared with C/C+C/T (P<0.001; OR = 1.32). We detected similar positive results in the subgroups ‘Caucasian’, and ‘glioma’ (all P<0.05; OR > 1). However, we detected negative results in our analyses of most of the other subgroups (P>0.05). Begg’s and Egger’s tests indicated that the results were free of potential publication bias, and sensitivity analysis suggested the stability of the pooling results. In summary, the T/T genotype of MGMT rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population.
Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis
Authors: Ji Shuaifei , Chen Xuemin , Shi Heng , Zhang Babo , Yao Shun , Deng Senlin , Tian Chunlong , Jiang Jun , Chen Fei , Wang Xiaocheng
Published: September 2018

Recent years, the discussion about whether platelets participant in the development of sudden sensorineural hearing loss (SSHL) continues and many studies on the relationship between them have come to our attention. Some studies believe that platelet parameters have significantly changed in patients with SSHL, while some not, controversially. Therefore, to investigate the association between platelet parameters, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PLT), and SSHL, expecting to resolve controversy and provide clinical evidence for diagnosis and monitoring of SSHL. Basic methods: Literature was retrieved searching electronic databases (PubMed, Embase, Cochrane, and Scopus) and searching references of related articles by hand. A total of 18 case–control studies involving 1837/1734 subjects (SSHL/control) were included. Meta-analysis showed there was no difference between the patients who suffered SSHL and healthy controls in MPV level [standard mean difference (SMD) (95% confidence interval (CI)) = 0.16 (−0.07, 0.40), I2 = 80%, P<0.00001] and PLT [SMD (95% CI) = −0.03(−0.18, 0.12), I2 = 73%, P<0.00001]. While PDW exhibited significant difference [SMD (95% CI) = 0.85 (0.20, 1.49), I2 = 93%, P<0.00001]. Subgroup analysis about geographical area suggested PLT have obvious evidence for SSHL in Eastern country [SMD (95% CI) = 0.23 (0.14, 0.33), I2 = 0%, P=0.81]. Our study did not support a correlation between MPV and SSHL, while PLT may have clinical significance for SSHL in Eastern country. With insufficient data to explore the resource of heterogeneity for PDW, there is no decisive conclusion reached.
Sodium-glucose transporter 2 inhibition and cardiovascular events in patients with diabetes: information from clinical trials and observational real-world data
Authors: Ferrannini Giulia , Rydén Lars
Published: September 2018

Cardiovascular (CV) disease (CVD) is the main cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Despite optimal glycaemic control, standard antihyperglycaemic therapy failed to impact CV events in intervention trials; therefore, the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) issued a guidance to the pharmaceutical industry to specifically assess the CV outcomes and safety of new glucose-lowering drugs. Amongst them, sodium-glucose transporter 2 (SGLT2) inhibitors proved to not only provide good tolerance, few adverse effects, and good glycometabolic control, but also striking reduction in the risk of CV events. In this review, data from the main randomised controlled trials are presented, including post-hoc analyses looking into several aspects of CV protection. Moreover, the main findings from observational real-world studies to date are described, overall reassuring as regards to CV safety and efficacy of SGLT2 inhibitors. Finally, several mechanisms which might contribute to the cardioprotective effect of SGLT2 inhibition are depicted, including findings from recent mechanistic studies.
Solving non-LTE problems in rotational transitions using the Gauss–Seidel method and its implementation in the Atmospheric Radiative Transfer Simulator
Authors: Yamada T. , Rezac L. , Larsson R. , Hartogh P. , Yoshida N. , Kasai Y.
Published: September 2018

This article presents our implementation of a non-LTE solver in spherical symmetry for molecular rotational transition in static or expanding atmospheres. The new open-source code relies on the Gauss–Seidel Accelerated Lambda Iteration methodology that provides a rapid and accurate convergence of the non-LTE problems, which is now routinely used in astrophysical and planetary research. The non-LTE code is interfaced with the widely used package, the Atmospheric Radiative Transfer Simulator (ARTS), to facilitate spectral line simulations for various viewing geometries. In this paper we describe the numerical implementation, provide the first validation results for the populations against two other non-LTE codes, and then discuss the possible application. The quantitative comparisons are performed using an established ortho-water non-LTE model applied to cases of optical thick and thin conditions of Ganymede’s atmosphere. The differences in populations expressed as excitation temperatures show very good agreement in both cases. Finally, we also apply this model to a sample of data from the Microwave Instrument for the Rosetta Orbiter (MIRO) instrument. The new non-LTE package is demonstrated to be fast and accurate, and we hope that it will be a useful addition to the planetary community. In addition, being open source and part of the ARTS, it will be further improved and developed.
Optical observations of NEA 3200 Phaethon (1983 TB) during the 2017 apparition
Authors: Kim M.-J. , Lee H.-J. , Lee S.-M. , Kim D.-H. , Yoshida F. , Bartczak P. , Dudziński G. , Park J. , Choi Y.-J. , Moon H.-K. , Yim H.-S. , Choi J. , Choi E.-J. , Yoon J.-N. , Serebryanskiy A. , Krugov M. , Reva I. , Ergashev K. E. , Burkhonov O. , Ehgamberdiev S. A. , Turayev Y. , Lin Z.-Y. , Arai T. , Ohtsuka K. , Ito T. , Urakawa S. , Ishiguro M.
Published: September 2018

Context. The near-Earth asteroid 3200 Phaethon (1983 TB) is an attractive object not only from a scientific viewpoint but also because of JAXA’s DESTINY+ target. The rotational lightcurve and spin properties were investigated based on the data obtained in the ground-based observation campaign of Phaethon.

Aims. We aim to refine the lightcurves and shape model of Phaethon using all available lightcurve datasets obtained via optical observation, as well as our time-series observation data from the 2017 apparition.

Methods. Using eight 12-m telescopes and an optical imager, we acquired the optical lightcurves and derived the spin parameters of Phaethon. We applied the lightcurve inversion method and SAGE algorithm to deduce the convex and non-convex shape model and pole orientations.

Results. We analysed the optical lightcurve of Phaethon and derived a synodic and a sidereal rotational periods of 3.6039 h, with an axis ratio of a∕b = 1.07. The ecliptic longitude (λp) and latitude (βp) of the pole orientation were determined as (308°, −52°) and (322°, −40°) via two independent methods. A non-convex model from the SAGE method, which exhibits a concavity feature, is also presented.
The AMBRE Project: r-process elements in the Milky Way thin and thick discs
Authors: Guiglion G. , de Laverny P. , Recio-Blanco A. , Prantzos N.
Published: September 2018

Context. The chemical evolution of neutron capture elements in the Milky Way disc is still a matter of debate. There is a lack of statistically significant catalogues of such element abundances, especially those of the r-process.

Aims. We aim to understand the chemical evolution of r-process elements in Milky Way disc. We focus on three pure r-process elements Eu, Gd, and Dy. We also consider a pure s-process element, Ba, in order to disentangle the different nucleosynthesis processes.

Methods. We take advantage of high-resolution FEROS, HARPS, and UVES spectra from the ESO archive in order to perform a homogeneous analysis on 6500 FGK Milky Way stars. The chemical analysis is performed thanks to the automatic optimization pipeline GAUGUIN. We present abundances of Ba (5057 stars), Eu (6268 stars), Gd (5431 stars), and Dy (5479 stars). Based on the [α/Fe] ratio determined previously by the AMBRE Project, we chemically characterize the thin and the thick discs, and a metal-rich α-rich population.

Results. First, we find that the [Eu/Fe] ratio follows a continuous sequence from the thin disc to the thick disc as a function of the metallicity. Second, in thick disc stars, the [Eu/Ba] ratio is found to be constant, while the [Gd/Ba] and [Dy/Ba] ratios decrease as a function of the metallicity. These observations clearly indicate a different nucleosynthesis history in the thick disc between Eu and Gd–Dy. The [r/Fe] ratio in the thin disc is roughly around +0.1 dex at solar metallicity, which is not the case for Ba. We also find that the α-rich metal-rich stars are also enriched in r-process elements (like thick disc stars), but their [Ba/Fe] is very different from thick disc stars. Finally, we find that the [r/α] ratio tends to decrease with metallicity, indicating that supernovae of different properties probably contribute differently to the synthesis of r-process elements and α-elements.

Conclusions. We provide average abundance trends for [Ba/Fe] and [Eu/Fe] with rather small dispersions, and for the first time for [Gd/Fe] and [Dy/Fe]. This data may help to constrain chemical evolution models of Milky Way r- and s-process elements and the yields of massive stars. We emphasize that including yields of neutron-star or black hole mergers is now crucial if we want to quantitatively compare observations to Galactic chemical evolution models.
The chemical composition of the oldest nearby open cluster Ruprecht 147
Authors: Bragaglia Angela , Fu Xiaoting , Mucciarelli Alessio , Andreuzzi Gloria , Donati Paolo
Published: September 2018

Context. Ruprecht 147 (NGC 6774) is the closest old open cluster, with a distance of less than 300 pc and an age of about 2.5 Gyr. It is therefore well suited for testing stellar evolution models and for obtaining precise and detailed chemical abundance information.

Aims. We combined photometric and astrometric information coming from literature and the Gaia mission with very high-resolution optical spectra of stars in different evolutionary stages to derive the cluster distance, age, and detailed chemical composition.

Methods. We obtained spectra of six red giants using HARPS-N at the Telescopio Nazionale Galileo (TNG). We also used European Southern Observatory (ESO) archive spectra of 22 main sequence (MS) stars, observed with HARPS at the 3.6 m telescope. The very high resolution (115 000) and the large wavelength coverage (about 380–680 nm) of the twin instruments permitted us to derive atmospheric parameters, metallicity, and detailed chemical abundances of 23 species from all nucleosynthetic channels. We employed both equivalent widths and spectrum synthesis. We also re-derived the cluster distance and age using Gaia parallaxes, proper motions, and photometry in conjunction with the PARSEC stellar evolutionary models.

Results. We fully analysed those stars with radial velocity and proper motion/parallax in agreement with the cluster mean values. We also discarded one binary not previously recognised, and six stars near the MS turn-off because of their high rotation velocity. Our final sample consists of 21 stars (six giants and 15 MS stars). We measured metallicity (the cluster average [Fe/H] is +0.08, rms = 0.07) and abundances of light, α, Fe-peak, and neutron-capture elements. The Li abundance follows the expectations, showing a tight relation between temperature and abundance on the MS, at variance with M 67, and we did not detect any Li-rich giant.

Conclusions. We confirm that Rup 147 is the oldest nearby open cluster. This makes it very valuable to test detailed features of stellar evolutionary models.
Does Fourier analysis yield reliable amplitudes of quantum oscillations?
Authors: Audouard Alain , Fortin Jean-Yves
Published: September 2018

Quantum oscillation amplitudes of multiband metals, such as high-Tc superconductors in the normal state, heavy fermions or organic conductors, are generally determined through Fourier analysis of the data even though the oscillatory part of the signal is field dependent. It is demonstrated that the amplitude of a given Fourier component can strongly depend on both the nature of the windowing (either flat, Hahn or Blackman window) and, since oscillations are obtained within a finite field range, the window width. Consequences on the determination of the Fourier amplitudes, hence of the effective masses, are examined in order to determine the conditions for reliable data analysis.
An analytical model for the magnetostriction strain of ferromagnetic materials subjected to multiaxial stress
Authors: Daniel Laurent
Published: September 2018

Magnetostriction is the magnetisation-induced strain in ferromagnetic materials. It highly depends on mechanical stress. Stress state in electromagnetic devices is usually multiaxial and its effect on magnetostrictive properties is not easily predicted. In this paper, an original three-parameter analytical model for the stress-dependent magnetostriction strain of ferromagnetic materials is proposed. It is based on a simplified energetic description of magneto-elastic behaviour. It follows a similar method previously adopted for the description of the effect of stress on the magnetic permeability of magnetic materials. It is applied for the first time to the magnetostriction behaviour and results in a simple formula to express the effect of multiaxial magneto-mechanical loadings on the magnetostriction strain. The approach also naturally includes the description of the so-called ΔE effect. The analytical formula is derived in the paper. It shows very satisfying agreement with experimental results on iron–cobalt alloy and pure iron specimen.
Hybrid Discontinuous Galerkin methods with relaxed H(div)-conformity for incompressible flows. Part II
Authors: Lederer Philip L. , Lehrenfeld Christoph , Schöberl Joachim
Published: September 2018

The present work is the second part of a pair of papers, considering Hybrid Discontinuous Galerkin methods with relaxed H(div)-conformity. The first part mainly dealt with presenting a robust analysis with respect to the mesh size h and the introduction of a reconstruction operator to restore divergence-conformity and pressure robustness (pressure independent velocity error estimates) using a modified force discretization. The aim of this part is the presentation of a high order polynomial robust analysis for the relaxed H(div)-conforming Hybrid Discontinuous Galerkin discretization of the two dimensional Stokes problem. It is based on the recently proven polynomial robust LBB-condition for BDM elements, Lederer and Schöberl (IMA J. Numer. Anal. (2017)) and is derived by a direct approach instead of using a best approximation Céa like result. We further treat the impact of the reconstruction operator on the hp analysis and present a numerical investigation considering polynomial robustness. We conclude the paper presenting an efficient operator splitting time integration scheme for the Navier–Stokes equations which is based on the methods recently presented in Lehrenfeld and Schöberl (Comp. Methods Appl. Mech. Eng. 307 (2016) 339–361) and includes the ideas of the reconstruction operator.
Simplified Design Equations for a Class of Rhombic Auxetic Plates
Authors: Lim Teik-Cheng
Published: September 2018

Equations for solving the deflection and bending moments of rhombic plates by exact method are known to be highly tedious. A set of simplified equations is developed for design purposes of such simply supported plates under uniform load. Curve-fitting from exact data allows the deflection and its second derivatives, evaluated at the plate centre, to be expressed in greatly simplified and yet sufficiently accurate empirical models for thin rhombic plates. Using the simplified model, it is shown that the maximum bending moment can be reduced by using auxetic materials. By including the effects of shear deformation for thick rhombic plates, it is demonstrated that the ratio of shear-to-bending deformation decreases as the rhombic plate approaches a square shape and as the plate’s Poisson’s ratio becomes more negative.
Construction Stability Analysis of Curved Continuous Rigid Frame Bridges with High Piers
Authors: Song Guohua , Li Minghui , Che Delu
Published: September 2018

Taking the curved continuous rigid frame bridges (CRFBs) with high piers as research object, the construction stability of four different styles of main piers were analyzed by finite element (FE) method in three construction stages including the segment 0 stage, largest cantilever stage, and finished bridge stage. Rules governing the stabilities of bridges with various pier styles, height, and slenderness ratio were established. At different construction stages, pier type and pier height affect structural stability differently. Wind loads have little influence on structural stability at any construction stage, and accidental events influence the stability of bridges more than normal construction loads. There is a nonlinear power relationship of fixed functional type between the stability safety factor (SSF) and slenderness ratio in all four pier styles; this power relationship can be used to predict the stability of a new pier.
Current Status of Degraded Road Bridge Slab Located in Mountainous Area
Authors: Maki Yuji , Ha Tuan Minh , Fukada Saiji , Torii Kazuyuki , Ono Ryohei
Published: September 2018

In the mountainous area of the Hokuriku region, bridges are suffering early deterioration caused by salt damage, alkali-silica reaction (ASR) and frost damage. Under such a regional situation, the load carrying capacity evaluation of these bridges has become an urgent issue. In this study, a statistical method–survival analysis–was carried out by using inspection data for bridges in the Hokuriku region, and the relationship between degradation tendency of bridges and regional characteristics causing salt damage, ASR and frost damage has been studied. In addition, the degradation causes of the reinforced concrete deck of a road bridge which deteriorated early in the mountainous area of the Hokuriku region were investigated. Cylindrical core extraction was carried out to analyze the degradation causes. Polarizing microscopic observation of specimens collected from RC slabs confirmed that cracks developed from the andesite particles and cracks were confirmed to be filled with ASR gels. Therefore, ASR was a cause of the deterioration. Moreover, the degradation in the mechanical properties of concrete due to ASR was also studied and reported. The results show that the reduction in compressive strength and static elastic modulus of both dry and leakage-water parts affected the load bearing capacity of the structure.
Parameter Analysis on the Anti-Impact Behavior of Pcfst Columns under Lateral Impact Load
Authors: Xu W , Zhu A Z , Gao K
Published: September 2018

Concrete-filled steel tubular (CFST) structures have been widel y used in civil engineering structures, due to its good behaviors under both static and dynamic loads. In this paper, numerical studies were carried out to investigate the anti-impact behavior of partially concrete-filled steel tubular (PCFST) columns under lateral impact loads. Finite element analysis (FEA) model was established using ABAQUS. To validate the FEA model, the numerical results were compared with experimental results. Moreover, parameter analysis was carried out to further study the anti-impact behaviors of the PCFST columns. The concrete filling height, the impact energy, the impact direction, and the yield strength of steel were the main parameters considered in this study. The dynamic responses under the impact load, including the impact force, the failure mode, and the displacement response, were all analyzed. The results of parameter analysis showed that the anti-impact behaviors of the PCFST columns significantly increased when the concrete filling height or the yield strength of steel increased greatly. The impact energy and direction also greatly affected the anti-impact behaviors of the PCFST columns.
Trial to Determine Durability and Serviceability for Swine Farm in Thailand
Authors: Lapcharatsangroj L , Chalida U-tapao
Published: September 2018

In agricultural construction, the most frequently used construction material is concrete. In particular swine farm, traditional concrete flooring system in the business is conventional concrete. However, the conventional concrete floor has several key issues on its surface. They are easily to be spalled and cracked, pig scour, rough areas, and low wear resistance of acid from animal feed. This research involves study in the ratio between Portland cement and supplementary materials (fly ash and silica fume) that is the most resistant to abrasion. Concrete samples were cured in water for 28 days, then submersed in lactic acid solution at 30 °C (pH 2-3). After exposure to the acid solution, every 7, 14, 28, and 56 days, the samples will be test for attrition on the face of concrete in accordance with ASTM C944 to simulate the acceleration reaction refer to animal behaviour and corrosion from acid of feed. From experiment, it was found that increasing the volume of fly ash and silica fume can increase concrete resistance to corrosion due to acid derived from feed.
Impact of the Content Variation of the Different Recycled Wastes to the Properties of Concrete Paving Block
Authors: Wang X , Chin C S , Xia J
Published: September 2018

Recycled concrete aggregates have been widely studied and used in concrete products nowadays. However, other recycled wastes, such as glass, have not been involved too much in recycled aggregate concrete studies. This paper aims to study the impact of the content variation of the different recycled wastes to the properties of the concrete paving block. In this paper, not only recycled coarse concrete aggregates, crushed glass are also used as the recycled aggregate in the concrete paving block in different replacement levels. According to test the properties of blocks mixed with different recycled wastes, the experimental results indicate that: (1) adding recycled concrete coarse aggregate (RCCA) in the blocks can decrease the blocks’ strength, and increase the water absorption. The suggested replacement levels for RCCA is 60%; (2) mixing crushed glass (CG) in the concrete paving blocks as a type of coarse aggregates can obviously improve the blocks’ strength and decrease the blocks’ water absorption.
Impact Resistance of High-Performance Steel Fiber Concrete under Long Term Exposure to Environmental Conditions
Authors: Abubakar Abdulhameed Umar , Akçaoğlu Tulin , Marar Khaled
Published: September 2018

An investigation is presented here that studied the influence of long-term environmental conditions exposure on cylindrical specimens after initial 28 day moist curing. The specimens were tested after six months subjected to Mediterranean weather elements in North Cyprus. Specimens with 150 mm diameter by 60 mm long cylinders were tested under impact load using a modified version of the testing equipment described in ACI 544.2R. Numbers of blows to create first and damage cracks were determined, and subsequently the impact energies calculated. It was seen that there is as much as twenty times improvement in impact energy of fibered concretes at fiber volume of 2% when compared with plain concrete. This will goa long way to improve the impact resistance of industrial floors and slabs on grade.
Effect of Temperature and Asphalt Binder Type on the Properties of Foamed Asphalt Mix
Authors: Bitolog Martin , Bouraima Mouhamed Bayane , Zhang Xiao-hua , Ndjegwes Christian Magloire , Qiu Yanjun
Published: September 2018

In this study, an effect of temperature on both indirect tensile strength (ITS) test and Marshall Stability Test of foam asphalt mixture using Shell #70 A asphalt is firstly investigated. A detailed investigation of the mechanical properties of foam asphalt mixture was then carried out using two different asphalt binders. The experimental work compares the mechanical properties of foam asphalt mixes including water stability test, indirect tensile strength (ITS) test, and freeze-thaw splitting test. The test results indicate that the foam asphalt mixture is temperature dependent and also temperature sensitive material. The foaming properties of asphalt have an important effect on the properties of the foam asphalt mixture for the strength and water stability of the foam asphalt mixture.
Modeling and Simulation Technology of High Frequency Vibratory Stress Relief Treatment for Complex Thin -Walled Workpiece
Authors: Zhao Xian-yang , Zhang Nian-song , Wang Ai-min
Published: September 2018

The current research based on vibratory stress relief (VSR) is focused on low frequency excitation, but it is seldom mentioned for complex thin-walled workpiece with higher natural frequency. In this paper, the mechanism of high frequency VSR is studied by microdynamic theory. Aiming at the rotating frame of complex thin-walled workpiece in aerospace equipment, the high frequency VSR numerical simulation is carried out by finite element software Abaqus, the modal analysis technology and harmonic response analysis technology are proposed, and the exciting force, excitation frequency and other important parameters are determined. The simulation results are analyzed to verify the superiority of high frequency VSR to eliminate residual stresses of complex thin-walled workpieces, and provide a theoretical basis for optimal selection of excitation parameters for high frequency VSR.
Organisation bipartite de la lymphopoïèse humaine
Authors: Alhaj Hussen Kutaiba , Chabaane Emna , Canque Bruno
Published: September 2018

L’étude de l’hématopoïèse humaine a longtemps été limitée par l’accès aux prélèvements primaires de moelle osseuse. Afin de s’affranchir de cette contrainte, une approche originale de modélisation chez la souris immunodéficiente a été développée dans notre laboratoire. L’analyse de l’ensemble des populations cellulaires humaines générées dans la moelle osseuse des animaux greffés a permis d’établir une nouvelle cartographie de l’hématopoïèse humaine. Nous montrons que, contrairement aux prédictions du modèle canonique de l’hématopoïèse, la lymphopoïèse humaine présente une organisation bipartite, articulée autour de l’existence de deux familles de progéniteurs lymphoïdes identifiées par l’expression différentielle du récepteur de l’interleukine 7 (CD127). Outre leurs différences phénotypiques, les progéniteurs lymphoïdes CD127-et CD127+se distinguent par leurs capacités de différenciation, leur dépendance vis-à-vis de facteurs de croissance, leurs modalités de restriction de potentiel, ainsi que par leurs signatures transcriptionnelles.