bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação de repositórios de dados de pesquisa segundo critérios da Encontrabilidade da Informação | Evaluation of research data repositories according to Information Findability criteria
Authors: Sanchez Fernanda Alves , Vechiato Fernando Luiz
Published: January 2020

RESUMO A busca por melhorias nos processos de partilha, uso e reuso de dados de pesquisa, cresce exponencialmente graças as transformações tecnológicas. O artigo aborda discussões sobre a ampliação da comunicação e colaboração científica, em especial, a partilha das produções científicas não tradicionais, realizada por meio dos repositórios de dados de pesquisa. Trata-se de metodologia exploratória de abordagem qualitativa para correlacionar os atributos de Encontrabilidade da Informação com os sistemas da Arquitetura da Informação, nesse tipo de ambiente. Os resultados apontam a relevância dos referidos estudos teórico-práticos na implementação e avaliação dos repositórios.Palavras-chave: Ciência Aberta; Dados de Pesquisa; Repositório de Dados de Pesquisa; Encontrabilidade da Informação; Arquitetura da Informação.ABSTRACT The search for improvements in the processes of sharing, use and reuse of research data, grows exponentially thanks to technological transformations. The article approaches discussions on the expansion of scientific communication and collaboration, in special, the sharing of non-traditional scientific productions, carried out through research data repositories. It is an exploratory methodology of qualitative approach to correlate the attributes of Information Findability with the Information Architecture systems, in this type of environment. The results point out the relevance of these theoretical-practical studies in the implementation and evaluation of the repositories.Keywords: Open Science; Search Data; Search Data Repository; Information Findability; Information Architecture.
Apresentação | Foreword
Authors: Sales Luana , Sayão Luís Fernando
Published: January 2020

Apresentação | Foreword
БИОТИЗАЦИЯ ОБРАЗА ЖИЗНИ ОБЫВАТЕЛЯ В ИДЕОЛОГИЧЕСКОЙ ТРАДИЦИИ АМЕРИКАНСКОГО ФИЛЬМА УЖАСОВ
Authors: Маленко Сергей Анатольевич , Некита Андрей Григорьевич
Published: January 2020

Актуальность. Переосмысление классических политических доминант актуализирует смыслы взаимодействия государства, общества и индивида. Отказ от прямого физического принуждения побуждает к поиску идеологических механизмов социального контроля. Голливуд становится медийным рупором биотической трансформации политики, а фильм ужасов превращается в наиболее эффективную модель визуализации этих технологий. Цель работы – проанализировать методологические стратегии биотизации обывательской повседневности в пространстве современной массовой культуры посредством идеологической экспансии традиции американских фильмов ужасов. Методы: комплекс компаративистских, семиотических и психоаналитических методов, анализирующих художественный опыт кинематографа и его мифологию. Результаты. Голливудские фильмы ужасов выступают апробированным средством сублимации, деформации и потребительского замещения ментального ядра любых конкурирующих социокультурных традиций. Американская визуальная хоррор-культура эффективно вытесняет потенциал агрессии внутри страны, превращаясь в прибыльную пропагандистскую технологию формирования и продвижения патомифа. Он воспроизводит преимущественно физиологические мотивы коммуникации индивида с окружающим миром, пропагандирует идейную доминанту биологически сильной особи как фундамент социокультурной коммуникации постчеловеческого типа. Американский фильм ужасов обнуляет экзистенциальный опыт человечества и находится в авангарде ревизии традиций не только европейской, но и мировой культуры. Выводы. Голливудская модель биовласти разрушает культурные традиции и исторический опыт, конструирует и продвигает антропологическую и социокультурную сингулярность человеческой особи, понимаемую как ее единичность в противостоянии отчужденному социуму, а периодически накапливающаяся «интоксикация» голливудским ужасом компенсируется иллюзией американской геополитической гегемонии.
On the total vertex irregularity strength of comb product of two cycles and two stars
Authors: Ramdani Rismawati
Published: January 2020

Let G = (V(G),E(G)) be a graph and k be a positive integer. A total k-labeling of G is a map f : V ∪ E → {1,2,3,...,k}. The vertex weight v under the labeling f is denoted by w_f(v) and defined by w_f(v) = f(v) + \sum_{uv \in{E(G)}} {f(uv)}. A total k-labeling of G is called vertex irregular if there are no two vertices with the same weight. The total vertex irregularity strength of G, denoted by tvs(G), is the minimum k such that G has a vertex irregular total k-labeling. This labelings were introduced by Baca, Jendrol, Miller, and Ryan in 2007. Let G and H be two connected graphs. Let o be a vertex of H. The comb product between G and H, denoted by G \rhd_o H, is a graph obtained by taking one copy of G and |V(G)| copies of H and grafting the i-th copy of H at the vertex o to the i-th vertex of G. In this paper, we determine the total vertex irregularity strength of comb product of two cycles and two stars.
Rainbow connection number of Cm o Pn and Cm o Cn
Authors: Maulani Alfi , Pradini Soya , Setyorini Dian , Sugeng Kiki A.
Published: January 2020

Let G = (V(G),E(G)) be a nontrivial connected graph. A rainbow path is a path which is each edge colored with different color. A rainbow coloring is a coloring which any two vertices should be joined by at least one rainbow path. For two different vertices, u,v in G, a geodesic path of u-v is the shortest rainbow path of u-v. A strong rainbow coloring is a coloring which any two vertices joined by at least one rainbow geodesic. A rainbow connection number of a graph, denoted by rc(G), is the smallest number of color required for graph G to be said as rainbow connected. The strong rainbow color number, denoted by src(G), is the least number of color which is needed to color every geodesic path in the graph G to be rainbow. In this paper, we will determine  the rainbow connection and strong rainbow connection for Corona Graph Cm o Pn, and Cm o Cn.
Keragaman arthropoda herbivora dan musuh alami pada tanaman padi lahan rawa di Rowopulo Kecamatan Gumukmas Kabupaten Jember
Authors: Adnan Muflih , Wagiyana W
Published: January 2020

Rowopulo is one of the swamps in Gumukmas, Jember Regency with its unique soil in the form of peat soil that floats on water and by the community used for rice cultivation, whose production is influenced by the presence of Plant Pests, which is dominated by the Herbivod Arthropods. The presence of herbivorous Arthropods in the swampland rice ecosystem can be suppressed by the presence of useful Arthropod populations such as predators, parasitoids, and pollinators. Related to this, a study was conducted to find out the diversity of Arthropods found in swampy rice plantations. The study began with a land survey, then the determination and marking of observation plots on the map and matching these locations using GPS (Global Positioning System). Observations were made on plots that were made based on the extent of rice plants that were still in one stretch and the same irrigation flow. Each plot was observed ten times at 7-day intervals from rice plants aged 14 days after 77 days after planting. Arthropod sampling using sweep net method. Catching arthropods are put into vials of 5 ml size and then identified up to family level, and the diversity, evenness, and wealth index of the species is calculated. The results of research on swamp rice plants contained 37 families. Ten families act as herbivorous Arthropods, 15 families as predators, six families as parasitoids, one family as pollinators, and five families as detritivores. The highest diversity index in plot 1 was 2.95, while the lowest in plot 2 was 2.70, with the medium category for all observation plots. The magnitude of the diversity index is due to the dominance of only a few orders, such as Orthoptera and Diptera; the highest species wealth index in plot 3 with a value of more than 4 in the high category; Evenness index of all observation plots has a value of less than 1 with uneven categories.  

Keywords: arthropods, diversity, natural enemies, swamp land
SAFAHAT’TAN SEÇMELER AHLAK
Authors: GÜLER Zülfi
Published: January 2020

Mehmet Akif bir sosyolog, bir ahlakçıdır. Safahat, İslam ahlakının
öğretilmesi amacıyla yapılan öğütlerle doludur. Hurafelerden arınmış İslam
ahlakını öğretmeğe çalışır Akif. Bu ahlak, felsefi anlamda genel ahlak
kurallarına uygundur; filozofların belirlediği temel ahlak erdemlerini de
içerir. Bu ahlaka, bu erdemlere sahip bir nesil hayal etmiş ve adına Asım’ın
nesli demiştir; bilgili, yiğit, doğru, iffetli, adil bir nesil.
CHOMSKY’NİN EVRENSEL DİLBİLGİSİ KURAMI TEMELİNDE ÇAĞDAŞ TÜRK LEHÇELERİNDE SIFAT-FİİLLİ YAPILARIN KARŞILAŞTIRILMASI
Authors: KARABULUT Ferhat , ARI ÖZDEMİR Tuba
Published: January 2020

Her
dilin kendine has biçimbilimsel ve söz dizimsel yapıları vardır. Bu yapılar
bazen başka dillerle benzerlik gösterebilir. Buna Chomsky İlkeler (Principles) adını verir. Baz yapılar ise sadece belli bir
dile aittir. Bu yapılara ise Chomsky değiştirgenler (parameters) adını verir. Yani İlkeler, her dilde
karşımıza çıkan ve evrensel özellik gösteren kurallardır. Değiştirgenler de dillerdeki farklılıkları ve dillere özel kuralları işaret
eder. Bununla birlikte ilkeler ve değiştirgenler
kuralı aynı dilin lehçeleri ve hatta ağızları arasında da söz konusu
olmaktadır. Başka bir deyişle her dilin de kendi içinde (alt kollarında) hem
ilkeler yani dil içi evrensellikler
hem de değiştirgenler kaçınılmaz olarak mevcuttur. Dilin çağdaş lehçeleri için
söz konusu olan ilkeler ve değiştirgenler kuralı, kuşkusuz, her dilin tarihi ve
çağdaş dönemi karşılaştırıldığında da söz konusudur.

Dillerin
veya herhangi bir dilin yapısal analizlerinde Chomsky’nin Evrensel Dilbilgisi Kuramı önemli ipuçları verir. Yine Chomsky
kuramlarının önemli kavramları olan derin
yapı ve yüzey yapı çok önemlidir.
Bir dilin analizinin tam olarak yapılabilmesi için, o dilin hem tarihsel
yapısının hem de lehçeler arasında meydana gelen yapıların birlikte ele
alınması gerekir. Underhill, Chomsky kuramları temelinde, Türkçedeki sıfat
fiilleri iki gruba ayırmış ve bunlara özne
sıfat fiiller ve nesne sıfat fiiller
adını vermiştir.

Bu
çalışmada; Türk Dilinin (Çağdaş Türk Lehçelerinin) en önemli yapılarından olan
sıfat-fiilli yapılar Chomsky kuramları temelinde ele alınmış ve karşılaştırmalı
bir analiz yapılmıştır. Çalışmada,
Underhill’in yöntemi benimsenmiş ve -An
ve -DIK sıfat-fiil yapısı ile
kurulmuş cümleler esas alınmıştır. İlk olarak sıfat fiilli cümleler Türkiye
Türkçesi’nde tespit edilmiştir. İkinci olarak bu cümleler yazı dili olarak
kullanılan 18 Türk lehçesinde bu lehçenin ana dil konuşurlarına sorularak
yeniden kurgulanmıştır. Üçüncü olarak bu cümleler Underhill’in özne sıfat-fiil
ve nesne sıfat-fiil ayrımına dayanarak analiz edilmiştir.
Divulgar, solicitar e restringir
Authors: Eirão Thiago Gomes , Leite Fernando César Lima
Published: January 2020

Trata do estudo do acesso à informação pública no contexto dos países do Cone Sul. A partir do estudo das leis que disciplinam a questão em cinco países do Cone Sul: Argentina, Brasil, Chile, Paraguai e Uruguai, o presente trabalho investiga as características e a consonância dos textos legais com as diretrizes teóricas de acesso à informação pública preconizadas por Braman (2004, 2006, 2011), Mendel (2009) e o Modelo Interamericano de Lei de Acesso à Informação (2012). Os dados coletados permitem inferir que há um núcleo que sustenta o acesso à informação nesses países tendo como foco a divulgação, a solicitação e a restrição de informações como conceitos mais identificados com a literatura.
Chitosan Synthesis and Optimization of Root Endophytic Fungi
Authors: Khastini Rida Oktorida , Munandar Aris , Sari Indah Juwita
Published: January 2020

The cell wall component of root endophytic fungi is a main source of chitosan synthesis. This research aimed to optimize chitosan synthesis from three different isolated species of root endophytic fungi in Pulau Dua Nature Reserve, Banten Indonesia. Three species of root endophytic fungi, namely, Aspergillus niger, Aureobasidium sp., Basipetospora sp., were cultured to produce chitosan. To optimize the production of fungal chitosan, cultures were treated with different conditions such as growth medium (Oat Meal broth, Potato Dextrose Broth, CMMY Broth), pH value (4, 5, 6, 7), and temperature (25, 30, 35, 40°C). Chitosan was extracted from dried mycelium after treated on NaOH 10% at 121°C for 2 min. The degree of deacetylation (DD) of chitosan was then examined and compared with the control (shrimp chitosan). The optimum fungal chitosan condition was higher in CMMY medium, pH 5, and 30°C. The DD value of three root endophytic fungi species, Aspergillus niger, Aureobasidium sp., Basipetospora sp. were 88.5, 83.3, 80.8, respectively, which was lower than DD value resulted from control. This study indicates that Aspergillus niger was a potential endophytic fungi for chitosan synthesis.
Privacidade e transparência: aplicação dos testes de dano e interesse público em recursos da LAI
Authors: Bezerra Queiroz Ribeiro Érica , Amaral Machado Bruno
Published: January 2020

A partir da análise documental de amostra de 100 decisões da Controladoria-Geral da União (CGU) em recursos contra negativa de acesso a informações, discute-se a relevância da aplicação dos testes de dano e do interesse público para a interpretação das hipóteses legais de restrição do acesso a informações, conforme previstas na Lei nº 12.527/2011 (LAI). A pesquisa evidenciou que a aplicação dos testes facilitou o registro dos raciocínios jurídicos adotados para avaliação dos riscos e interesses relacionados à promoção da transparência e à proteção de sigilos legais, especialmente da privacidade. Os testes também tornaram possível garantir a transparência da implementação da política de transparência pública, na medida em que resultam em um conjunto de precedentes construído de modo coordenado e tendente à coerência, a partir de casos semelhantes e precedentes administrativos.
A Garantia Constitucional da “Responsabilidade Gerencial”: Responsabilidade por Resultados dos Dirigentes Públicos nos Sistemas Brasileiro e Italiano e as Relações entre Órgãos Políticos e Administrativos
Authors: Celone Cristiano , Noberto Robl Filho Ilton
Published: January 2020

O Estado de Direito contemporâneo pressupõe a adoção da democracia constitucional, a qual busca o equilíbrio entre decisões majoritárias e o respeito aos direitos fundamentais, e a prestação de atividades e serviços públicos eficientes. Nesse contexto, insere-se a responsabilidade gerencial da administração pública. A hipótese principal teórica sustentada afirma que o exercício dos cargos gerenciais e de gestão pela alta burocracia e para buscar resultados com autonomia e com poder de planejar e executar políticas públicas é a forma adequada de relacionar política e administração pública. No Brasil, os modelos de administração pública e de responsabilidade gerenciais foram introduzidos especialmente por meio da Reforma do Estado na década de noventa do século passado, pela Emenda Constitucional n. 19/2008 e atualmente pela Lei Federal n. 13.934/2019.
Kualitas Pelayanan Persalinan di Rumah Sakit Ibu dan Anak Sriratu Medan
Authors: Ndruru Desi Lustiyani Putri , Wau Herbert , Manalu Putranto
Published: January 2020

Layanan kesehatan yang berkualitas adalah layanan kesehatan yang efisien, sebaliknya layanan kesehatan yang kurang atau tidak bermutu adalah akan membuat layanan organisasi menjadi sangat boros dan mengelurkan biaya yang mahal. Berdasarkan hasil survei awal yang telah dilakukan, data kunjungan ibu bersalin di Rumah Sakit Ibu dan Anak (RSIA) Sri Ratu Medan dalam tiga tahun terakhir menunjukan angka yang menurun pada tahun 2015 sebanyak 681 ibu bersalin, tahun 2016 sebanyak 573 ibu bersalin, tahun 2017 sebanyak 505 ibu bersalin. Penelitian ini bertujuan untuk mengetahui hubungan kualitas pelayanan persalinan dengan kepuasan ibu bersalin di RSIA Sri Ratu Medan. Metode penelitian yang digunakan adalah penelitian kuantitatif dengan pendekatan cross- sectional. Populasi dalam penelitian ini adalah pasien ibu bersalin di RSIA Sri Ratu Medan dengan jumlah sampel 83 orang. Analisis dengan menggunakan uji Chi-square dengan α<0,05. Hasil penelitian menunjukan bahwa nilai p-value antara bukti fisik (p-value = 0,001), kehandalan (p-value = 0,000), daya tanggap (p-value = 0,001), jaminan (p-value = 0,115), perhatian (p-value = 0,243) terhadap kepuasan ibu bersalin di RSIA Sri Ratu Medan. Terdapat hubungan yang bermakna antara bukti fisik, kehandalan, daya tanggap terhadap kepuasan ibu bersalin dan tidak terdapat hubungan yang bermakna antara jaminan dan perhatian terhadap kepuasan Ibu Bersalin di RSIA Sri Ratu Medan.
Congratulations! The Fourth JDR Award
Authors: Hayashi Haruo
Published: January 2020

The Fifth JDR Award ceremony was held in Kanda, Japan, at December 18, 2019 and a prize were given to Doctor Yuichiro Usuda, National Research Institute for Earth Science and Disaster Resilience (NIED), Japan. We congratulate the winner and sincerely wish for future success.
Improvement of Elementary School Students’ Competence of Reading Comprehension through Generative Learning Model
Authors: Saepurokhman Asep
Published: January 2020

ABSTRACT

Reading comprehension is a competence that everyone has to possess. It can broaden human’s insight in that we will not be left behind as time goes so fast. One of the teachers’ efforts as to enhance the reading comprehension competence is to apply a learning model that is able to explore a lot of students’ potency. The learning model considered to be capable of developing the students’ creative-thinking is a generative model. Based on the result of data analysis, it is known that the process of reading-comprehension learning runs well in full activity of students. The students’ tendency to the learning of reading comprehension using such a model is positive in the means of 75.10%. The generative learning model succeeds in enhancing the students’ competence of reading comprehension. The means of score before the treatment is only 53.80%, whereas after the treatment it gets 72% in which the index gain is 0.41 and it is categorized into mediocre. There is difference of reading-comprehension competence between the use of generative learning model and conventional model. It is proven by t-test, indicating that t-observed is higher than t-table. Therefore, the generative learning model is effective and reasonable to use for the teachers in the improvement of stduents’ reading-comprehension competence.
Etapas de la administración: hacia un enfoque sistémico
Authors: Pantoja-Aguilar Martín P. , Salazar Garza-Treviño José Rodrigo
Published: January 2020

Rev.esc.adm.neg

El objeto de esta investigación se centra en homologar un análisis cronológico de las etapas de la administración hasta llegar a su actual enfoque sistémico. Se inicia con los precursores de la administración desde la civilización China en la cual se sentaron las bases de un enfoque pragmático, y se abordan las diferentes etapas que condujeron a la humanidad hacia la revolución industrial cuando las maquinas sustituyeron a la mano de obra. El artículo presenta un análisis crítico del surgimiento de la administración científica como una respuesta a la creciente demanda por estilos más humanos y sociales para ordenar la labor administrativa. Aplicando un análisis metodológico de cada etapa de las teorías de la administración bajo la visión de un enfoque sistémico, detectando las características que fueron aportando a la construcción de los nuevos modelos y su desenlace en los modelos actuales con enfoque sistémico, revisando desde los principios de la administración científica establecidos por Taylor, hasta la crítica que señalaba la falta de atención de los diferentes factores psicológicos y sociales relacionados con el ser humano. Se concluye de esto que el nuevo enfoque sistémico es el resultado de un proceso de evolución de la teoría administrativa, así como del análisis de la adaptación y tropicalización de cada escuela administrativa con respecto a las necesidades de cada época, pero con una visión de futuro que conduce a una utopía con cierto grado de realismo.
An Integrated Experimental Method to Investigate Tool-Less Temporary-Plugging Multistage Acid Fracturing of Horizontal Well by Using Self-Degradable Diverters
Authors: Zhang Lufeng , Zhou Fujian , Mou Jianye , Feng Wei , Li Zhun , Zhang Shicheng
Published: January 2020

Tool-less temporary-plugging multistage acid fracturing of horizontal well is a necessary technology to unlock the production potential and enable commercial productivity for tight carbonate reservoirs. However, this technique has not been investigated experimentally yet, and the plugging behavior of diverters within acid-etched fracture is still unclear. In this paper, we propose an integrated method to experimentally study tool-less multistage fracturing with diverters. First, we introduce an innovative 3D printing method to reproduce the roughness of acid-etched fracture surface and design an acid-etched fracture temporary plugging evaluation system to satisfy the requirements of temporary plugging experiments. Then, we conduct a series of plugging experiments to optimize the diverter's formula for creating a tight plugging zone within an acid-etched fracture under different fracture widths. On the basis of the description of the fracture surface, we further analyze the formation process and mechanism of temporary plugging. Finally, we further verify through laboratory experiments using a modified true tri-axial fracturing system the feasibility of using a single type of diverter and combined diverters to achieve tool-less temporary plugging staged fracturing of horizontal well. The experimental results show the following findings: (1) Pure fibers can realize temporary plugging at lower fracture width (≤2 mm). (2) To achieve temporary plugging, the diameter of particulates should not be less than half of the fracture width under the condition of larger fracture width (≥4 mm). (3) The fracture surface morphology affects the formation time of temporary plugging, but does not affect whether temporary plugging is formed or not. (4) Using a steel plate with a smooth fracture surface to conduct optimization experiments will increase the dosage of diverters, thus increasing the operation cost. (5) Pure particulates cannot achieve favorable plugging effect. This study provides an insight into multistage acid fracturing.
Verifying participant reported clinical outcomes: challenges and implications
Authors: Breeman Suzanne , Constable Lynda , Duncan Anne , Starr Kath , McDonald Alison , Wileman Samantha , Cotton Seonaidh
Published: January 2020

Background Researchers often rely on trial participants to self-report clinical outcomes (for example fracture, re-operation). Little information exists as to the “accuracy” of participant reported clinical outcomes, particularly in randomised controlled trials (RCTs). To help address this evidence gap, we report four case-studies, nested within different RCTs where participant reported clinical outcome data were compared with that reported by clinicians or extracted from medical notes. Methods Four publicly-funded RCTs with different methods of verifying participant reported outcomes were identified: KAT: Participants were asked about hospital admissions for any reason. Where it was thought to be relevant to the trial knee, further information was sought from the lead surgeon at the admitting site to confirm whether or not the admission was relevant to the trial knee. REFLUX: Participants were asked about hospital admissions for any reason. For participants who reported a re-operation, further information was sought from the lead surgeon at the admitting site to confirm this. RECORD: Participants were asked three questions regarding broken bones. Where they were thought to be low-trauma fractures, clinical verification was sought, initially from the research nurse at site. CATHETER: Participants were asked about urinary tract infections (UTIs) and a prescription of antibiotics for treatment of UTIs following urethral catheterisation. The GPs of those who reported a UTI were contacted to confirm that an antibiotic prescription had been issued for the suspected UTI. Results KAT: 397 of 6882 (6%) participant reported hospital admissions were confirmed as relevant to the trial knee. REFLUX: 16 of 19 participants (84%) who appeared to have had a re-operation were confirmed as having had one. RECORD: 473 of 781 (61%) fractures reported by participants were confirmed as low-trauma fractures. CATHETER: 429 of 830 participant reported UTIs (52%) were confirmed as such by the GPs. Conclusions We used different approaches to the verification of participant reported outcomes in clinical trials, and it is our opinion that there is no one optimal solution. Consideration of issues such as what information is sought from participants, the phrasing of questions, whether the medical records are a true “gold standard” and costs and benefits to the RCT may help determine the appropriate approach.
Randomized Controlled Trials for Comparison of Laparoscopic Versus Conventional Open Catheter Placement in Peritoneal Dialysis Patients: A Meta-Analysis
Authors: Sun Mei-Lan , Author) Yong Zhang(Former Corresponding , Wang Bo , Ma Tean , Jiang Hong , Hu Shou Liang , Zhang Piao , Tuo Yan-Hong
Published: January 2020

Aim: The application of laparoscopic catheterization technology in peritoneal dialysis (PD) patients has recently increased. However, the advantages and disadvantages of laparoscopic versus conventional open PD catheter placement are still controversial. The aim of this meta-analysis is to assess the complications of catheterization in PD patients and to provide a reference for choosing a PD-catheter placement technique in the clinic.Methods: We searched numerous databases, including Embase, PubMed, CNKI and the Cochrane Library, for published randomized controlled trials (RCTs).Results: Eight relevant studies (n=646) were included in the meta-analysis. The pooled results showed a lower incidence of catheter migration (OR: 0.42, 95% CI: 0.19 to 0.90, P: 0.03) and catheter removal (OR: 0.41, 95% CI: 0.21 to 0.79, P: 0.008) but a higher incidence of bleeding (OR: 3.25, 95% CI: 1.18 to 8.97, P: 0.02) with a laparoscopic approach than with a conventional approach. There was no significant difference in the incidence of omentum adhesion (OR: 0.32, 95% CI: 0.05 to 2.10, P: 0.24), hernia (OR: 0.38, 95% CI: 0.09 to 1.68, P: 0.20), leakage (OR: 0.69, 95% CI: 0.38 to 1.26, P: 0.23), intestinal obstruction (OR: 0.96, 95% CI: 0.48 to 1.91, P: 0.90) or perforation (OR: 0.95, 95% CI: 0.06 to 15.42, P: 0.97). The statistical analysis showed no significant difference in early (OR: 0.44, 95% CI: 0.15 to 1.33, P: 0.15) , late (OR: 0.89, 95% CI: 0.41 to 1.90, P: 0.76) or total (OR: 0.68, 95% CI: 0.42 to 1.12, P: 0.13) peritonitis infections between the 2 groups, and there are no no significant difference in early ( OR: 0.39, 95% CI: 0.06 to 2.36, P: 0.30), late ( OR: 1.35, 95% CI: 0.78 to 2.33, P: 0.16) or total ( OR: 1.20, 95% CI: 0.71 to 2.02, P: 0.17) tunnel or exit-site infections between the 2 groups.Conclusion: Laparoscopic catheterization and conventional open catheter placement in PD patients have unique advantages, but laparoscopic PD catheterization may be superior to conventional open catheter placement. However, this conclusion needs to be confirmed with further large-sample-size, multi-centre, high-quality RCTs.
Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis
Authors: Li Li , Li Zhenxing , Li Yuyan , Hu Xi , Zhang Yu , Fan Pei
Published: January 2020

Background: Inflammatory mediators in the synovial fluid (SF) play critical roles in the initiation and development of pain in knee osteoarthritis (KOA). However, data for inflammatory marker expression are conflicting, and the role of SF inflammatory mediators in neuropathic pain is not clear. Therefore, the aim of this study was to identify SF inflammatory mediators associated with nociceptive and neuropathic pain in KOA. Methods: Levels of IL-1β, IL-6, TNF-α, macrophage colony-stimulating factor, MMP-3, MMP-13, metalloproteinase with thrombospondin motifs 5, calcitonin gene-related peptide, neuropeptide Y, substance P and bradykinin were measured using enzyme-linked immunosorbent assays in 86 patients. Nociceptive pain was assessed using the numeric rating scale (NRS), visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score. Neuropathic pain was determined using the PainDETECT questionnaire. Moreover, knee function was evaluated by the WOMAC score and range of motion (ROM) assessments. Radiological grade was defined using the Kellgren-Lawrence (K-L) grading scale. Results: Pain scores measured using different methods correlated highly with each other. A worse K-L grade and knee function were associated with worse pain. Expression of IL-1β and IL-6 was increased in the early stage compared with the late stage. The NRS score correlated positively with age, K-L grade, and the WOMAC score and negatively with ROM and TNF-α expression. The VAS correlated positively with age, K-L grade, and the WOMAC score but negatively with ROM and levels of IL-1β, IL-6 and TNF-α. The WOMAC pain score did not correlate with any of the inflammatory mediators measured; it correlated only with ROM. The PainDETECT score correlated only with the WOMAC score. Expression of other inflammatory mediators did not correlate with any of the pain scores. Conclusions: IL-1β, IL-6 and TNF-α play critical roles in pain in the early stage of KOA and correlate with pain. The catabolic enzymes and neuropeptides measured do not correlate with nociceptive and neuropathic pain. New biomarkers related to pain in the late stage need to be further investigated.
Knowledge, attitude and practice of mothers on prevention and control of intestinal parasitic infection among their preschool children in Sekota town, Waghimra zone, Ethiopia
Authors: Kassaw Mesfin Wudu , Abebe Ayele Mamo , Abate Biruk Beletew , Zemariam Alemu Birara , Kassie Ayelign Mengesha
Published: January 2020

Background: Intestinal parasitic infection is one of the common communicable diseases across the world. Globally, more than 1.5 billion individuals infected with one or more parasitic agents. Of the victim individuals, 700 and 807 million people were infected by Hookworm and Ascariasis respectively. Intestinal parasites are prevalent in developing countries and to the most in sub-Saharan Africa. The prevalence of helminthiases in Ethiopia range from 27.2% to 85.1%. Particularly, young children have a high infestation rate and they suffer from a substantial burden of Ascaris lumbricoides,Trichuris trichiura, and Schistosomiasis. Therefore, this study was intended to assess mother’s knowledge, attitude and practice on prevention and control of intestinal parasitic infection among their pre-school children in Sekota town, Ethiopia.Methods: A community based descriptive cross-sectional study was conducted on 378 mothers using simple random sampling method, and gave a response rate of 98.4%. The findings are presented in percentage, frequency and tables. In all of the data collection, data analysis, and write up phases, a standard operational procedure was followed. A bivariate covariate analysis were undertaken to assess the correlation of total knowledge, attitude, and practice scores. Results: The level of good maternal knowledge, positive maternal attitude, and good maternal practice in preventing and controlling intestinal parasitic infection on their preschool children was 45.2% (95% CI, 40.2, 50.5), 55.3% (95% CI, 50.8, 61.1), and 51.1 (95% CI, 46.0, 56.1) respectively. In assessing mothers knowledge, seventy seven (20.4%) of them reported that they knew Ascaris lumbricoides, and on the maternal practices in preventing IP infection, 62 (16.4%) mothers wash vegetables, and 252 (66.7%) mothers stated that their children had at least one history of stool examination. Conclusions: The overall level of good maternal knowledge, positive maternal attitude, and good maternal practice on prevention and control of intestinal parasites was low. Specifically, the level of knowledge was significantly low. Therefore, community awareness about intestinal parasitic infection prevention and control methods should be created.
Patient-reported quality indicators to evaluate physiotherapy care for hip and/or knee osteoarthritis- development and evaluation of the QUIPA tool.
Authors: Teo Pek Ling , Hinman Rana S , Egerton Thorlene , Dziedzic Krysia S , Kasza Jess , Bennell Kim L
Published: January 2020

Background: There is no physiotherapy-specific quality indicator tool available to evaluate physiotherapy care for people with hip and/or knee osteoarthritis (OA). This study aimed to develop a patient-reported quality indicator tool (QUIPA) for physiotherapy management of hip and knee OA and to assess its reliability and validity.
Methods: To develop the QUIPA tool, quality indicators were initially developed based on clinical guideline recommendations most relevant to physiotherapy practice and those of an existing generic OA quality indicator tool. Draft items were then further refined using patient focus groups. Test-retest reliability, construct validity (hypothesis testing) and criterion validity were then evaluated. Sixty-five people with hip and/or knee OA attended a single physiotherapy consultation and completed the QUIPA tool one, twelve- and thirteen-weeks after. Physiotherapists (n=9) completed the tool post-consultation. Patient test-retest reliability was assessed between weeks twelve and thirteen. Construct validity was assessed with three predefined hypotheses and criterion validity was based on agreement between physiotherapists and participants at week one.
Results: A draft list of 23 clinical guideline recommendations most relevant to physiotherapy was developed. Following feedback from three patient focus groups, the final QUIPA tool contained 18 items (three subscales) expressed in lay language. The test-retest reliability estimates (Cohen’s Kappa) for single items ranged from 0.30-0.83 with observed agreement of 64-94%. The intraclass correlation coefficient (ICC) and 95% confidence interval (CI) for the Assessment and Management Planning subscale was 0.70 (0.54, 0.81), Core Recommended Treatments subscale was 0.84 (0.75, 0.90), Adjunctive Treatments subscale was 0.70 (0.39, 0.87) and for the total QUIPA score was 0.80 (0.69, 0.88). All predefined hypotheses regarding construct validity were confirmed. However, agreement between physiotherapists and participants for single items showed large measurement error (Cohen’s Kappa estimates ranged from -0.04-0.59) with the ICC (95% CI) for the total score being 0.11 (-0.14, 0.34).
Conclusions: The QUIPA tool showed acceptable test-retest reliability for subscales and total score but inadequate reliability for individual items. Construct validity was confirmed but criterion validity for individual items, subscales and the total score was inadequate. Further research is needed to refine the QUIPA tool to improve its clinimetric properties before implementation.
Recognition of stroke among community residents and the improvement after intensive health education: A cross-sectional study.
Authors: Zhong Xuemin , Wang Jian , He Lanying , Xu Ronghua
Published: January 2020

Background: This study aimed to investigate stroke recognition in a community population (including high-risk groups of stroke) in Jinjiang District of Chengdu and strengthen the publicity of the impact of stroke-related knowledge on community residents’ stroke recognition.
Methods: By conducting an epidemiological survey, nine communities in Jinjiang District were sampled, and a questionnaire on stroke-related knowledge was designed to investigate the community residents in Jinjiang District of Chengdu City. We carried out stroke health education activities with the theme of “understanding stroke” and evaluated the impact.
Results: There were 1685 valid questionnaires, and the awareness level of stroke risk among community residents in Jinjiang District of Chengdu was 11.4%. The proportion of people who recognized that there was a risk of stroke increased with the increase in the number of risk factors (P < 0.001). Participants with three or more risk factors were aware that the risk of stroke was only 40.3%. The recognition rate of stroke warning symptoms among community residents was 29.8–59.5%. Among them, the recognition rate of common stroke symptoms such as limb weakness, language disorder, and imbalance was more than 50%, and the cognitive proportion of rare symptoms including monocular or binocular blurred vision and severe headache with no known cause was only about 1%. When faced with five sudden stroke warning symptoms, the proportion of participants who chose to make an emergency call (120, in China) was about 41.5%. Nearly 10% of the respondents chose to consult a doctor, take medicine, or wait. After strengthening publicity and education, there was a significant improvement in the identification of stroke risk factors, stroke warning symptoms, and stroke management. The number of respondents who chose to dial 120 increased from 59.2% to 82.7%.
Conclusions: The recognition of stroke among community residents in Jinjiang District of Chengdu is low. Strengthening publicity and education on stroke-related knowledge and post-stroke treatment can significantly improve patients’ cognition of stroke-related knowledge and enhance community residents’ awareness of giving priority to dialing 120 after the onset of stroke symptoms.
Key words: stroke, community residents, warning symptoms, intensive education
lncRNA NEAT1 Inhibits Proliferation, Invasion and Epithelial-mesenchymal Transition of Gastric Cancer Cells by Regulating MiR-129-5p/PBX3 Axis
Authors: Ji Hanshu , Zhang Xiaoyu
Published: January 2020

Purpose: lncRNA NEAT1 has been reported as a tumor-promoting gene in a variety of tumors, but few studies have explored its role and mechanism in gastric cancer. In the face of increasing incidence of gastric cancer, how to improve the diagnostic accuracy and therapeutic effect of gastric cancer is a major clinical problem. Therefore, we studied the effect and mechanism of lncRNA NEAT1 on the proliferation, invasion and epithelial-mesenchymal transition of gastric cancer cells. To inquiry into the effect of lncRNA NEAT1 on the proliferation, invasion and epithelial-mesenchymal transition (EMT) of gastric cancer (GC) cells by regulating miR-129-5p/PBX3 axis. Methods: Totally 63 GC diagnosed and treated in our hospital were selected as the study subjects, whose paired GC tissues and pericarcinomatous tissues were collected as the study specimens after obtaining their consent. QRT-PCR was employed to detect the NEAT1 expression in tissues and cells to analyze the relationship between NEAT1 and clinicopathological data of GC patients. In addition, stable and transient overexpression and inhibition vectors were established and transfected into GC cells HCG-27 and MKN-45. CCK-8, traswell, and flow cytometry were employed to evaluate the proliferation, invasion, and apoptosis of transfected cells. The correlation of miR-129-5p between PBX3 and NEAT1 was assessed using dual luciferase reporter assay, while that between NEAT1 and miR-129-5p was assessed by RNA-binding protein immunoprecipitation (RIP) . Western blot was applied for the detection of apoptosis and EMT related proteins.Results: NEAT1 was overexpressed in GC patients and had a high diagnostic value. The expression of NEAT1 was related to the pathological stage, differentiation degree, tumor size and lymph node metastasis of patients with GC. Down-regulated NEAT1 brought decreased cell proliferation, invasion and EMT, and increased apoptosis. According to dual luciferase reporter assay, NEAT1 could target miR-129-5p, while in turn miR-129-5p could target PBX3. Functional analysis exhibited that miR-129-5p overexpression inhibited PBX3 in GC cells, affecting cell proliferation, invasion, EMT and apoptosis, and rescue experiments demonstrated that these effects were eliminated by up-regulating NEAT1 expression.Conclusion: Inhibition of NEAT1 could mediate miR-129-5p/PBX3 axis to promote apoptosis of GC cells, and reduce cell proliferation, invasion and EMT.
Still careless: Findings from a cross-sectional study of young pedestrians’ risky road crossing behaviors
Authors: Hashemiparast Mina , Sharma Manoj , Jafarabadi Mohammad Asghari , Hosseini Zahra
Published: January 2020

Background Pedestrian-vehicle collision is one of the most common traffic injuries worldwide. This study aimed to investigate the determinants of pedestrians' road crossing beliefs and behaviors in potentially risky situations using the Theory of Planned Behavior among Iranian young adults. Methods This was a population-based study on a sample of 562 young adults aged 18 to 25 years living in Tehran, Iran. The data were collected using a self-administered validated questionnaire comprising of two potentially risky road crossing behaviors scenarios followed by additional items assessing perceived risk and severity. Results From all the respondents, 17.8% reported that they had previous experience of vehicle-collision while the remaining 82.2% did not. The results indicated that those with previous experience reported fewer safety behaviors than those who did not experience an accident. There were significant differences between participants with and without a history of vehicle-collision for perceived risk (mean difference, adjusted multivariate P-value: -5.77, 0.027) and perceived severity (-6.08, 0.003), attitude toward traffic regulations (-6.34, 0.006), attitude toward behavior (-7.56, 0.005), perceived behavioral control (-5.20, 0.018), behavioral intention (-5.35, 0.046) and road crossing behavior in potentially risky situations (-5.37, 0.004). Conclusions Previous unpleasant experience of vehicle-collision is not the only determinant of self-protective behaviors in the road- crossing and it is important to focus on the effect of attitudinal and motivational factors such as attitudes towards risk, feelings of invulnerability and perception of vehicle- collision severity as well. Future safety education interventions should keep these aspects in their design.
Development and validation of a RAD-Seq target-capture based genotyping assay for routine application in advanced black tiger shrimp (Penaeus monodon) breeding programs
Authors: Guppy Jarrod Lee , Jones David B. , Kjeldsen Shannon R. , Port Agnes Le , Khatkar Mehar S. , Wade Nicholas M. , Sellars Melony J. , Steinig Eike J. , Raadsma Herman W. , Jerry Dean R. , Zenger Kyall R.
Published: January 2020

Background The development of genome-wide genotyping resources has provided terrestrial livestock and crop industries with the unique ability to accurately assess genomic relationships between individuals, uncover the genetic architecture of commercial traits, as well as identify superior individuals for selection based on their specific genetic profile. Utilising recent advancements in de-novo genome-wide genotyping technologies, it is now possible to provide aquaculture industries with these same important genotyping resources, even in the absence of existing genome assemblies. Here, we present the development of a genome-wide SNP assay for the Black Tiger shrimp ( Penaeus monodon ) through utilisation of a reduced-representation whole-genome genotyping approach (DArTseq). Results Based on a single reduced-representation library, 31,262 polymorphic SNPs were identified across 660 individuals obtained from Australian wild stocks and commercial aquaculture populations. After filtering to remove SNPs with low read depth, low MAF, low call rate, deviation from HWE, and non-Mendelian inheritance, 7,542 high-quality SNPs were retained. From these, 4,236 high-quality genome-wide loci were selected for bates-probe development and 4,194 SNPs were included within a finalized target-capture genotype-by-sequence assay (DArTcap). This assay was designed for routine and cost effective commercial application in large scale breeding programs, and demonstrates higher confidence in genotype calls through increased call rate (from 80.2 ± 14.7 to 93.0% ± 3.5%), increased read depth (from 20.4 ± 15.6 to 80.0 ± 88.7), as well as a 3-fold reduction in cost over traditional genotype-by-sequencing approaches. Conclusion Importantly, this assay equips the P. monodon industry with the ability to simultaneously assign parentage of communally reared animals, undertake genomic relationship analysis, manage mate pairings between cryptic family lines, as well as undertake advance studies of genome and trait architecture. Critically this assay can be cost effectively applied as P. monodon breeding programs transition to undertake genomic selection at less than $15 AUD per sample.
Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds
Authors: xiong ying , Hao Yan , Cheng Yalin , Fan Liqing , Song Gang , Li Dongming , Qu Yanhua , Lei Fumin
Published: January 2020

Background Pectoralis phenotypic variation plays a fundamental role in locomotion and thermogenesis in highland birds. However, its regulatory and metabolic mechanisms remain enigmatic to date. Here, we integrated phenomic, transcriptomic and metabolomic approaches to determine muscle variation and its underpinning mechanisms across altitudinal songbirds. Results Phenomics revealed that all highland birds had considerable increases in muscle oxidative capacity, capillarity, and mitochondrial abundance. Correspondingly, transcriptomic analyses found that differentially expressed genes in modules associated with phenotypes enriched in blood vessel, muscle structure development, and mitochondrial organization. Despite similar traits and functional enrichments across highland birds, different mechanisms drove their occurrence in part for their own various evolutionary histories. Importantly, a metabolic feature shared by highland birds is the improvement in insulin sensitivity and glucose utilization through activating insulin signaling pathway, which is vital to increase muscle oxidative capacity and maintain metabolic homeostasis. Nevertheless, fatty acid biosynthesis and oxidation are enhanced in species with a long evolutionary history, also differing from ketone body metabolism in recently introduced colonizer. Conclusions Our study represents a vital contribution to reveal the regulatory and metabolic basis of pectoralis variation across altitudinal songbirds.