bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical Management of a Torn ACL and Bucket-Handle Meniscal Tear in the Pregnant Patient
Authors: Filtes Peter , Beckerman Marc A. , Austin Kimberlee , Buckley Patrick S. , Swan Kenneth G.
Published: April 2024

Update

This article was updated on June 7, 2024 because of a previous error. One author's name was incorrect. The correct name is Marc A. Beckerman, MD.

An erratum (JBJS Case Connect. 2024;14[2]:e23.00423ER) has been published for this article.

Case:

A 36-year-old, 7-month pregnant woman presented to the office with a locked knee and a displaced bucket-handle medial meniscus tear, in the setting of chronic anterior cruciate ligament (ACL) insufficiency. After thorough discussion with the patient and her husband, the obstetrician, and the anesthesiologist, the patient was treated with left knee ACL reconstruction and medial meniscus repair.

Conclusion:

With sufficient preoperative planning and coordinated multidisciplinary care among orthopaedic, anesthesiologist, and obstetric specialists, elective knee surgery can be performed safely in time-sensitive situations during pregnancy.
New and Traditional Treatment Options for Idiopathic Scoliosis in Children and Adolescents
Authors: Andreeff Renee , Andreeff Autumn
Published: April 2024

Scoliosis is a medical condition common in children and adolescents, which causes an abnormal curvature of the spine in a “C” or “S” shape. Three main forms of scoliosis exist: neuromuscular, congenital, and idiopathic with idiopathic being most common. Traditional treatments include observation, rigid bracing (a corrective orthosis), casting, surgery, and physiotherapeutic scoliosis-specific exercises. Surgical corrections include spinal fusion or placement of traditional or growing rods. Treatment options for scoliosis have recently expanded, to include newer flexible bracing and surgical procedures such as tethering and posterior dynamic deformity correction. Providers should be screening for scoliosis, and all providers can benefit from knowing the latest options available to help their patients receive the best care before reaching skeletal maturity.
MEASURING THE COMPETITIVENESS OF TÜRKİYE'S INDUSTRIES AGAINST THE EUROPEAN UNION ACCORDING TO THE TECHNOLOGY INTENSITY: AN EVALUATION WITHIN THE FRAMEWORK OF THE CUSTOMS UNION REVISION
Authors: Demir Gökçe , Aydın Üzeyir , Utkulu Utku
Published: April 2024

Identifying the industries with competitive power and knowing their places in the world market regarding proper policy implementations is essential. This paper aims to determine the normalized competition levels of Türkiye against the European Union (EU) countries in the context of industries with different technology intensities and to evaluate these industries within the scope of the planned Customs Union revision. For this purpose, firstly, the static comparison of Ballassa's Revealed Comparative Advantage (BRCA) index is calculated for 1990-2021. After, the dynamic comparison of Normalized Revealed Comparative Advantage (NRCA) index is calculated for 1990-2021. Analysis was made by considering the temporal comparison variation of NRCA. According to the research findings, the Customs Union adversely affects competitiveness in low and medium-low technology sectors where Türkiye is competitive. The results show the importance and necessity of the Customs Union revision.
Bibliometric Analysis of Studies of Published in the Field of Volatility
Authors: Şahin Özkan , Bil Erkan
Published: April 2024

Volatility, which is used to determine the risk structure of financial markets or instruments, is one of the most used methods by researchers. In this study which is conducted to reveal the tag of volatility studies, 11,894 articles related to volatility between 1975 and 2020, which were scanned in the Web of Science database, were subjected to bibliometric analysis. As a consequence of the investigation, the details of the subject such as the country with the highest number of publications, institutions, the most cited authors, articles, leading journals and keywords in the field were revealed. As a consequence of the, it was determined that the authors worked on three basic subjects such as "stocks and stock markets", "exchange rates" and "macroeconomic indicators" on volatility. It has been observed that the main objectives of the studies conducted are either to compare the performance of existing volatility estimation models or to develop new models by adding new variables.
Auge y declive del Distrito Textil de Trafalgar de Barcelona: un análisis espacio-temporal (1916-2016)
Authors: Vicente-Salar Rafael , Pallares-Barbera Montserrat , Vera Martín Ana
Published: April 2024

El artículo examina los factores que influyen en la dinámica de las economías de aglomeración intraurbanas provenientes de los distritos textiles urbanos durante el siglo XX, centrándose en el Distrito Textil de Trafalgar (DTT) de Barcelona, especializado desde principios del siglo XX en la industria textil, de la confección y el sector mayorista –industria TCM. A través de una metodología mixta, los resultados señalan que a medida que la industria TCM se globaliza, las ventajas asociadas a las economías de localización intraurbanas se diluyen afectando a la estructura productiva del DTT y dependiendo de las economías de urbanización para su supervivencia. Sin embargo, en la actualidad el papel de las instituciones formales ha sido parte clave en la dilución de las ventajas asociadas a la centralidad urbana que beneficiaba la viabilidad del DTT comportando su progresivo declive. Este estudio contribuye a la literatura al analizar el papel de las economías de aglomeración intraurbanas desde una perspectiva microgeográfica e histórica en distritos textiles urbanos, los cuales han recibido escasa atención en el ámbito nacional.
Formation of isoamyl alcohol and isobutanol in the fermentation of sugarcane molasses in a microdistillery: evaluation of pH, refrigeration and supplementation factors
Authors: Santos Renan Atanázio dos , de Almeida Yeda Medeiros Bastos , Andrade Samara Alvachian Cardoso , Caldas Celso Silva , de Freitas Jonnathan Duarte , Costa Clara Andrezza Crisóstomo Bezerra
Published: April 2024

Fusel oil is a mixture of higher alcohols that are formed during fermentation, and the main constituents are isoamyl alcohol and isobutanol. Although their presence in fermented musts is detrimental to the distillation process and ethanol quality, the aforementioned higher alcohols are widely used, especially in the fine chemical industry. On the other hand, the quality and quantity of fusel oil depend on various factors, including raw materials and fermentation conditions. The aim of this study was to investigate the effects of pH, refrigeration, and supplementation on the formation of isoamyl alcohol and isobutanol during the fermentation of molasses must in a microdistillery. The fermentations were conducted in batches that were fed with 25 °Brix must and 25% v/v commercial dry yeast for 10 hours. A complete 2³ factorial design was used to assess the effects of the studied factors and their interactions on the response variables: fermentation efficiency (nf), process efficiency (np), ethanol productivity (P), substrate-to-cell conversion factor (YX/S), isoamyl alcohol produced (A), isobutanol produced (B) and the A/B Ratio between these alcohols. For statistical analysis, analysis of variance (ANOVA) and Tukey’s test were used for mean comparisons. The results of the substrate-to-cell conversion factor (YX/S) indicated good yeast performance under different fermentation conditions. The interaction effects among the evaluated factors significantly influenced the formation of isoamyl alcohol and isobutanol, as well as the A/B Ratio.
Bacterial cellulose as reinforcement for earthen material
Authors: KABALAN Ola NASHED , Roy Robert Le , Ciblac Thierry , Marceau Sandrine
Published: April 2024

The interest of reinventing raw earth is for the purpose of drastically reducing the environmental impact of the continuous human urban growth. This paper discusses the use of cellulose synthesized by bacteria as a new source of microfibers to reinforce the soil matrix. It presents firstly, the bacterial cellulose (BC) and its production method then it focuses on defining its microstructural characteristics. In the second part, the soil-BC association is studied. Commercial soil (DW-earth) and bentonite clay were tested with 3 and 8% of BC. The objective is to evaluate the impact of BC addition on the soil’s physcio -mechanical properties. Shrinkage and mechanical performance tests were carried out. The results showed a material with better mechanical performances and high cracks resistance. The shrinkage percentage decreased significantly for DW-earth with a similar water/solid ratio when adding BC, by about 18% and 22% when adding 3% and 8% BC for water content of 35%. In the case of bentonite clay the BC addition has only a positive impact on limiting cracking. The mechanical tests showed that 8% of BC increases the compressive strength of the cylindrical specimens by 28% and 649%, respectively for the DW-earth and bentonite clay, whereas the flexural strength of the prismatic specimens increases by 39% and 556%.
Factors Contributing to Disparities in Visual Acuity Prior To Cataract Surgery: An IRIS® Registry Analysis
Authors: Lorch Alice , Manz Sarah , Gilbert Joshua , Ross Connor , Elze Tobias , Miller Joan
Published: April 2024

Purpose
Access to and utilization of cataract surgery varies nationally. The purpose of this study was to characterize sociodemographic factors that predict best corrected visual acuity (BCVA) at the time of cataract surgery.
Design:
Retrospective cohort study.
Methods
This is a multicenter study of nearly 2.4M patients ≥ 50 years of age in the national IRIS® (Intelligent Research in Sight) Registry who had ≥ one BCVA measurement six months preceding cataract surgery. Estimating the relationship between race and ethnicity and preoperative BCVA, within and between ophthalmology practices, was the main outcome measure.
Results
Within a practice, preoperative BCVA was approximately 0.05 logarithm of the minimum angle of resolution (logMAR) lower for patients identified as White compared to all other racial and ethnic groups (p < 0.002). Uninsured and Medicaid-insured patients had worse preoperative BCVA (1.150, 0.097 logMAR higher, p = 0.006, 0.001, respectively). Between practices, a patient in a practice serving 10 percent more patients identified as Asian, Black, or Hispanic had higher preoperative BCVA, holding constant an individual’s race and ethnicity (0.009, 0.012, 0.014 logMAR higher, respectively, all p = 0.002).
Conclusions
Our results suggest that patients who do not identify as White, uninsured, and Medicaid-insured patients, will have worse vision prior to cataract surgery. Further, we observed that patients seen at practices serving a higher percentage of patients identified as Asian, Black, or Hispanic will have worse preoperative BCVA. These findings highlight the need for initiatives to address disparities in ophthalmic care.
Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome
Authors: Semenov Konstantin N. , Prokopiev Ilya A. , Petukhova Natalya V. , Kremenetskaya Uliana A. , Senichkina Dina A. , Epifanovskaya Olga S. , Rumiantsev Andrei M. , Andoskin Pavel A. , Ageev Sergei V. , Anufrikov Yurii A. , Zakharov Egor E. , Moiseev Ivan S. , Sharoyko Vladimir V.
Published: April 2024

This work is devoted to the study of biocompatibility, cyto- and genotoxicity, mechanism of action and prospects for the use of atranorin, which is an AKT kinase inhibitor, for the treatment of myelodysplastic syndrome. Atranorin was isolated by preparative flash chromatography; identification was carried out by UV, IR, and NMR spectroscopy, mass spectrometry, and elemental analysis. Biocompatibility studies included studies of haemocompatibility, genotoxicity, antioxidant activity, cytotoxicity against ECV340 and HEK293 cell lines. Computer modelling of the interaction of atranorin with AKT kinase was carried out using docking followed by molecular dynamics of the resulting complexes; the ADMET properties of atranorin were also calculated. Flow cytometry included analysis of the expression level of PD-L1 and TIM-3 in the presence of atranorin on THP-1, Mono-Mac-1 and KG-1 cell lines, as well as human bone marrow cells.
Validation and psychometric properties of the Chinese version of the questionnaire for assessing the childbirth experience (QACE)
Authors: Zhong Xiaoying , Wang Junbang , He Linqian , Li Xixi , Pan Changqing , Peng Lin
Published: April 2024

Background:The aim of this paper was to translate and determine the psychometric properties of the questionnaire for assessing the childbirth experience (QACE) among Chinese postpartum women (C-QACE).
Method:The cross-cultural adaptation process followed Beaton (2000) intercultural debugging guidelines. A total of 235 women were included to test the psychometric properties of the C-QACE. Participants were asked to complete the demographic characteristics form, the C-QACE, Edinburgh Postnatal Depression Scale (EPDS), and the Generalized Anxiety Disorder-7 (GAD-7). The psychometric testing of the C-QACE were evaluate through item analysis, exploratory factor analysis, divergent validity and internal consistency reliability.
Results: Item analysis showed that the critical ratios of all items were greater than 3 , and all item-total correlation coefficients were greater than 0.4. The finding of the exploratory factor analysis (EFA) revealed the presence of four components with eigenvalues greater than 1, explaining a total variance of 67.682%. And the scree plot showed it was acceptable to retain four factors (emotional status, relationship with staff, first moments with the new born, and feelings at one month postpartum). In terms of the divergent validity, the QACE subscale and total score were in a significant positive correlations with the EPDS and GAD-7. Regarding the internal consistency reliability, the Cronbach’s alpha of the QACE total score was 0.812, and the subscales was ranging of 0.611 to 0.844.
Conclusion: The Chinese version of QACE is a relevant tool for measuring childbirth experience into the Chinese context with acceptable validity and stability.
Piezo1 reduces inflammation regulatory ability of periodontal ligament cells to decelerate orthodontic tooth movement in response to heavy mechanical force
Authors: Zheng Leilei , Zhu Ye , Meng Xuehuan , Zhai Qiming , Xin Liangjing , Tan Hao , He Xinyi , Li Xiang , Yang Guoyin , Song Jinlin
Published: April 2024

Periodontal ligament (PDL) cells exhibit immunoregulatory characteristics and are being explored as promising therapeutic candidates for accelerating orthodontic tooth movement (OTM). The impact of light or heavy orthodontic mechanical force (MF) on PDL cellular regulatory ability and the modulation of alveolar bone remodeling during OTM is not yet fully understood. Piezo1, a mechanosensitive ion channel, is essential for mediating the conversion in response to MF stimuli. This study aimed to investigate the influence of light and heavy MF on OTM and the consequent remodeling of alveolar bone by altering the immunoregulatory capabilities of PDL cells through Piezo1 modulation. This research represents the initial exploration of the role of Piezo1 activation by either light or heavy MF in the modulation of mitochondrial calcium concentrations through mitochondria-associated endoplasmic reticulum membranes in PDL cells. The study results have validated that heavy MF-induced deregulation of mitochondrial calcium by Piezo1 leads to a decrease in the release of mitochondrial DNA into the cytoplasm, thereby inhibiting the cGAS-STING pathway activation. Inhibition of the cGAS-STING pathway leads to a decrease in the immunoregulatory capacity of PDL cells during OTM, resulting in reduced osteoclast remodeling and deceleration of rat and sting−/− OTM model. The cumulative findings of this study indicate that manipulating the immunoregulatory ability of PDL cells via Piezo1 could potentially offer an effective strategy to shorten the duration of orthodontic treatment.
A novel nomogram to predict the impact of polymorphism and plasma level of Mfn2 on risk of ischemic cardiomyopathy
Authors: Naman Tuersunjiang , Aimaier Salamaiti , Abudourexiti Muyashaer , Abuduhalike Refukaiti , Sun Juan , Mahemuti Ailiman
Published: April 2024

Objectives
In this study, we aimed to investigate the relation of polymorphism as well as plasma level of Mitofusion2(Mfn2) and occurrence of ischemic cardiomyopathy (ICM), then develop a predictive model which can predict the risk of ICM.
Methods
A total of 2052 participants were included in this study. These participants were randomly assigned to the training group [n = 1412 (70%)] and the validation group [n = 640 (30%)]. Univariable analysis was performed in the training group. Then, least absolute shrinkage and selection operator (LASSO) regression model were adopted, then, a multivariable logistic regression was performed to build the predictive model. We then constructed a nomogram incorporating the variables regarded as independent predictive factors using multivariable logistic regression analysis. Evaluated the model by Receiver operating characteristic (ROC) curves, calibration plot and decision curve analysis (DCA).
Results
The independent predicting factors incorporated into this nomogram were age, hemoglobin concentration, diabetes, ejection fraction, left-ventricular diastolic-end diameter, plasma Mfn2 concentration, and mutation in rs1042842 and rs2295281. Our constructed nomogram displayed favorable discrimination ability, Besides, the Hosmer–Lemshow test suggested that the model exhibited good consistency (P training group = 0.2655; P validation group = 0.3315). DCA revealed that our constructed ICM nomogram showed clinical benefits.
Conclusions
The plasma level of Mfn2 is a protective factor of ICM. Mutations of rs1042842 and rs2295281 are risk factors for ICM.
Relationship between bone metabolic markers and bone mineral density in natural postmenopausal women
Authors: Li Guohua , Abudushalamu Muyashaer , Muheremu Aikeremujiang
Published: April 2024

Objective: To investigate the relationship between bone metabolic markers and bone mineral density (BMD) in natural postmenopausal women more than 2 years after menopause.
Methods: A total of 147 women aged 45-72 years who had undergone natural menopause for more than 2 years were selected. Dual-energy X-ray Absorptiometry (DEXA) was used to scan the standard BMD of the lumbar spine and hip. Fasting venous blood was collected in the morning to detect serum bone metabolism markers like amino-terminal pro-peptide of type Ⅰ pro-collagen (PINP) and β-collagen degradation products (β-CTX). According to BMD the patients were divided into normal bone mass group, osteopenia group and osteoporosis group. The differences of PINP and β-CTX among the three groups were compared. The correlation between PINP, β-CTX and general data was analyzed. The correlation between lumbar BMD, hip BMD and each variable; Correlation between β-CTX and P1NP, lumbar spine BMD and hip BMD.
Results: P1NP had no significant difference among the three groups. PINP and β-CTX were not correlated with age, menopausal age, height, weight, BMI and glycosylated hemoglobin (P > 0.05). Lumbar spine BMD was correlated with age, menopausal age, height, weight and BMI (P < 0. 05), but not with Hba1c, PINP and β-CTX. Hip BMD was correlated with menopausal age, height, weight, BMI and β-CTX (P < 0. 05), but not with age, Hba1c and P1NP. 05), and lumbar BMD was correlated with hip BMD (P < 0. 05).
Conclusion: Bone resorption and bone formation are in a state of high metabolism, and osteoporosis patients may lose bone mass faster. Bone mineral density is better than PINP and β-CTX in reflecting bone mass.
Development and Validation of a dynamic online nomogram predicting acute kidney injury in critically ill patients with cirrhosis
Authors: Tu Huilan , Su Junwei , Gong Kai , Li Zhiwei , Yu Xia , Xu Xianbin , Shi Yu , Sheng Jifang
Published: April 2024

Background: This study aimed to develop a tool for predicting the occurrence of acute kidney injury (AKI) in critically ill patients with cirrhosis.
Methods: Eligible patients with cirrhosis were identified from the Medical Information Mart for Intensive Care database. Demographic data, laboratory examinations, and interventions were obtained. After splitting the population into training and validation cohorts, the least absolute shrinkage and selection operator regression model was used to select factors and construct the dynamic online nomogram. Calibration and discrimination were used to assess nomogram performance, and clinical utility was evaluated by decision curve analysis (DCA).
Results: A total of 1282 patients were included in the analysis, and 773 developed AKI. The mean arterial pressure, urine volume, white blood cell count, total bilirubin level, and Glasgow Coma Score were identified as predictors of AKI. The developed model had a good ability to differentiate AKI from non-AKI, with AUCs of 0.796 and 0.782 in the training and validation cohorts, respectively. Moreover, the nomogram model showed good calibration. DCA showed that the nomogram had a superior overall net benefit within wide and practical ranges of threshold probabilities.
Conclusions: The dynamic online nomogram can be an easy-to-use tool for predicting the individualized risk of AKI in critically ill patients with cirrhosis.
Evaluation of a new method of selective dry cow treatment using microbiological culture and antibiogram results
Authors: Navaei Hossein , Vojgani Mehdi , Khoramian Babak , Akbarinejad Vahid , Gharagozloo Faramarz , Garoussi Massoud Talebkhan , Momeni Amir
Published: April 2024

Background: Due to financial issues and the rise in antimicrobial resistance, updating dry cow therapy (DCT) methods is still being researched by scientists worldwide. This investigation aimed to evaluate a new method of selective treatment by choosing an appropriate dry ointment for each cow based on the individual culture and antibiogram results and examining its effects on clinical and subclinical mastitis indices, cure rate, new infection rate, and milk yield during the first 30 days in milk (DIM).
Results: For this research, a total of 291 Holstein dairy cows were selected from three herds. These cows had a somatic cell count (SCC) > 200,000 (cells/mL) just before the dry period, had positive composite milk culture results, and were gradually dried over five days. The milk samples were taken before dry-off and on the first day after parturition (1 DIM), as well as 3 days before dry-off and between 3 and 7 days postpartum to evaluate SCC. The cows were randomly divided into two groups of control (n = 151) and treatment (n = 140). The control group included cows that were treated with dry cow ointment regardless of the pathogens involved in mammary infection, and the treatment group contained cows that received DCT ointment based on the type of pathogen isolated during culture and the antibiogram results before dry-off. The results revealed that the cure rate in the treatment group was significantly better than in the control group (P = 0.0006). In addition, the rate of new intramammary infections (IMI, P = 0.0006) and the rate of clinical mastitis (P = 0.015) decreased in the first 30 DIM in the treatment group. Nevertheless, SCC and milk yield at the onset of the subsequent lactation did not differ significantly between the control and treatment groups (P > 0.05).
Conclusion: According to the findings of our study, based on individual milk culture and antibiogram results, selectively treating cows with appropriate dry ointments had significant benefits for increasing the cure rate of pathogens, lowering the incidence of new IMIs, and minimizing the risk of clinical mastitis in the first 30 DIM.
Optimization Method for Control Panel Layout of Manned Submarine Vehicle Based on Genetic-Ant Colony Algorithm
Authors: Xie Ning , Qiao Yidan , Shi Hongqi , Chen Dengkai
Published: April 2024

In traditional computer-aided design methods for manned submersible control panel layout, interactive input and modification are commonly used, which can’t support a global optimization process for the design layout. Therefore, the genetic-ant algorithm is introduced into the design of manned submersible control panel layouts. Based on the cognitive characteristics of humans, layout optimization principles are summarized and incorporated into the objective function variables during the optimization process. The fitness function, pheromone, and heuristic information expressions for optimizing the control panel layout of manned submersibles are studied to establish the genetic-ant algorithm flow for use in the optimization design process. Taking the control panel layout design of a certain type of manned submersible as an example, multi-objective optimization calculations are performed to quantify the layout principles and combine them with the algorithm, thus verifying the feasibility of the proposed method.
Effectiveness of Multimedia Education on the Childbearing Intention in One-Child Women: A Field Trial Study
Authors: Amini Leila , Jabbari Saber , Haghani Shima , Aghazadeh Nasrin
Published: April 2024

Background: childbearing is a key component of population movements and sustainable development in low-fertility nations. This study was conducted with the aim of determining the impact of multimedia education on the childbearing intention in One-child women of Maragheh city in 2023.
Method: In this intervention study in Maragheh in 2023, 94 women with one child were randomly selected and placed in two intervention and control groups. Before the intervention, people were examined using demographic information and Miller's questionnaire of desire to have children. Then, For the intervention group, three 60-minute multimedia training videos were shown in person for three weeks, and the control group did not receive any training. The data were collected using the researcher's demographic questionnaire and Miller's childbearing questionnaire in three stages before the intervention, immediately after and six weeks after the intervention. Data analysis was done with SPSS version 16 software.
Results: There was no significant difference between the two groups in terms of the average score of desire to have children and demographic variables (p>0.05). Before the intervention, there was no significant difference between the intervention and control groups in terms of the demographic characteristics of the subjects and the average score of women's willingness to have children in the positive and negative dimensions. While after the multimedia educational intervention, the average score of desire to have children in positive and negative dimensions, immediately after the intervention and six weeks after the intervention, had a significant difference compared to before the intervention (p<0.001).
Conclusion: The findings of the study showed that carrying out multimedia educational interventions to single-child women can have a positive effect on their desire to have children. It seems that the implementation of such programs is effective in the conscious decision of families to have children and ultimately increases the intention of the individual to carry out the behavior.
Trial registration: Iranian Registry of Clinical Trials: IRCT20230227057549N1. Date of registration: 16/04/2023. URL: https://irct.behdasht.gov.ir/
Predicting dementia progression with fully connected cascade neural networks
Authors: Akbarifar Ahmad , Maghsoudpour Adel , Mohammadian Fatemeh , Mohammadzaheri Morteza , Ghaemi Omid
Published: April 2024

Accurate and timely diagnosis of dementia progression remains a major global challenge due to the complexities of brain pathology and the lack of definitive biomarkers. This study presents a pioneering fully connected cascade (FCC) neural network model that leverages cost-effective lifestyle and neuroimaging data to predict dementia progression with remarkable accuracy. The model uniquely integrates 42 lifestyle factors for brain health (LIBRA) and 7 brain atrophy and lesion indice (BALI) derived from baseline MRI data as inputs, to predict sensitive diffusion tensor imaging (DTI) biomarkers of white matter degeneration. Remarkably, the FCC network achieved a mean squared error of 0.0071693 in predicting DTI metrics, demonstrating exceptional predictive capability. This multidisciplinary data-driven approach capitalizes on the model's ability to detect subtle yet informative changes in brain structure and function through advanced neuroimaging. By amalgamating multidomain lifestyle and neuroimaging data, the proposed model enhances diagnostic value and sensitivity to dementia pathology. Its high accuracy, scalability with large datasets, clinical interpretability, and cost-effectiveness make it a powerful computational tool for early prediction, monitoring, and personalized treatment planning in dementia care. This groundbreaking research exemplifies the transformative potential of artificial intelligence in tackling the global dementia burden, paving the way for improved patient outcomes and reduced healthcare costs.
Study on the Effects of a Ketogenic Diet Full-Cycle Management Platform in Children with Refractory Epilepsy
Authors: Wang Xingyanan , Ye Jinghua , Tian Xiaoqin , Wang Fangping
Published: April 2024

Objective:
To develop and explore the application effects of a Ketogenic Diet Full-Cycle Management Platform in the nursing care of children with refractory epilepsy undergoing a ketogenic diet.
Methods:
A prospective, non-synchronous control study was conducted. Thirty children undergoing a ketogenic diet from August to September 2023 were selected as the control group, while thirty children undergoing the diet from October to November 2023 served as the experimental group. The control group received standard nursing care, whereas the experimental group received interventions through the Ketogenic Diet Full-Cycle Management Platform, on top of the control group's regimen. The study compared the average daily seizure frequency, the average daily incidence of adverse reactions, and the average duration of the ketogenic diet between the two groups after four weeks.
Results:
The experimental group showed a decrease in seizure frequency and adverse reactions, along with an increased average duration of the ketogenic diet compared to the control group. These findings were statistically significant (P < 0.05).
Conclusion:
The Ketogenic Diet Full-Cycle Management Platform enables parents of affected children to more conveniently and quickly grasp the knowledge related to the ketogenic diet. Medical staff can timely understand changes in the children's diet through the platform, make adjustments as needed, and thus improve the quality and effectiveness of the ketogenic diet for children with refractory epilepsy.
Research on a Coal Seam Modeling Construction Method Based on Improved Kriging Interpolation
Authors: ZHANG Jing , LIU Guangwei
Published: April 2024

To make the Kriging interpolation more consistent with the actual coal seam shape, combine interpolation points into a triangular mesh, extract a large triangular mesh using MATLAB for local interpolation, then identify triangular meshes with similar normal vectors. Formulate them into a plane, remove interpolation points inside the plane. Finally, continue interpolation at the boundaries, generate a triangular mesh, clip using the original boundary lines to retain internal triangular meshes, re-establish the boundary lines, and ultimately disperse the boundary lines into points. The research results show that applying this method to the construction of the Dananhu No. 2 open-pit mine coal seam model has improved the problem of coal seam transition stiffness, such as abnormal large-area triangulation in areas with large elevation differences, saving about 27000KB, about the memory occupied by the four-layer coal seam model, preventing boundary line positioning due to reasons such as too small density of points on the coal seam reserve boundary line and transitions are inaccurate, making the model transition at the boundary smoother and more consistent with the actual coal seam change trend. This method can be extended to the construction of all mine models.
Properties of postbiotics produced by probiotics: antimicrobial, antioxidant activities and production of vitamins, organic acids
Authors: Ibrahim Gamal A. , Mabrouk Ahmed M. , El-Ssayad Mohamed F. , Mehaya Fathy. M. S. , Sharaf Osama M. , Ibrahim Mohamed I. M.
Published: April 2024

The current study was conducted to determine and investigate the antimicrobial, antioxidant activity, vitamins, organic acid and short-chain fatty acid composition of postbiotics produced by some probiotics. In this study, the antimicrobial activity of all postbiotics from tested probiotic strains showed zones of inhibition against most indicator strains, but with different diameters. The results show that L. acidophilus and L. helveticus had the largest inhibitory effects on pathogenic bacteria and fungi. The results also show that the postbiotics have antioxidant activity. It was observed that the L. plantarum strain had the highest antioxidant activity, followed by L. rhamnosus GG and B. bifidum. The results indicated that postbiotics produced by various strains contain many organic acids in different concentrations. In conclusion, different compounds detected in the postbiotics of the probiotic strains used in this study are in preparation for the next research on their nutritional evaluation to identify the best strains for application in functional dairy products.
Cohesive transcriptomic and in vitro approach revealed genes involved in inhibition of G0/G1, G2 phase of cell cycle pathway of stomach cancer cells by geraniol treatment
Authors: Perumalsamy Haribalan , Rahimi Shadi , Gokulanathan Anandapadmanaban , Jyothiraditya Vuluchala , Dhandapani Sanjeevram , Almoajel Alia , Subramanian Sivakumar Allur , Elsadek Mohamed Farouk , Balusamy Sri Renukadevi
Published: April 2024

The effects of geraniol on cell cycle related pathway in AGS using RNA sequencing have not been explored and it is largely unknown. In this study, we isolated geraniol from Cymbopogon martini (palmarosa) essential oil using various spectroscopic analyses. At first, we carried out the cytotoxicity of geraniol on AGS cells. In-depth RNA sequencing analysis showed that geraniol negatively regulated genes that specifically initiate double-strand break repair via DNA replication, mitotic G1, G2/M transition, and S phases in cell cycle, eventually leading to induce apoptosis. Additionally, we validated the interaction of geraniol with the cell cycle related genes using docking, Florescence-activated cell sorting (FACS) and quantitative polymerase chain reaction (qPCR) analysis. Overall, the present investigation shows that geraniol interacts with specific target genes involved in the cell cycle process and induce cell death in the stomach cancer cells, which can be suggested as the potential treatment for stomach cancer.
Adverse Childhood Experiences, School Bullying Retrospection, and the Impact on Resilience in Adulthood
Authors: Fountain Raisa , Beckstein Amoneeta
Published: April 2024

Adverse childhood experiences (ACEs) have been repeatedly shown to profoundly impact individual resilience in adulthood. ACEs and bullying experiences are linked with school disengagement, depression, anxiety disorders, and substance abuse. Moreover, ACEs are associated with lower life expectancy, increased risk of heart disease, and cancer. Experiencing bullying victimization had been shown to lead to lower educational attainment, unemployment, reduced income, and poorer general health and cognitive functioning in early to midlife. Yet, there remains a gap in understanding how ACEs and bullying interact to influence resilience in adulthood. This cross-sectional study aims to explore the compounded effects of ACEs and bullying on resilience scores. The study surveyed 255 Amazon MTurk workers selected by CloudResearch under 40 years old from the United States, assessing ACEs, bullying, and resilience. Surprisingly, mild to moderate experiences of past bullying were positively linked to resilience scores, counter to expectations. However, ACEs showed no direct relationship with resilience scores. These findings prompt further investigation, considering potential sample biases from using an MTurk population, and highlight implications for future research and practice.
Integrated analysis of disulfidptosis-related genes SLC7A11, SLC3A2, RPN1 and NCKAP1 across cancers Running title: Disulfidptosis-related genes across cancers
Authors: Zheng Zequn , Song Yongfei
Published: April 2024

Disulfidptosis, a newly identified form of regulated cell death associated with disruption of disulfide bond formation in the endoplasmic reticulum, involves the dysregulation of disulfidptosis-related genes (DRGs) that may contribute to cancer development and progression. However, the molecular mechanisms and clinical implications of DRGs in different cancer types remain poorly characterized. Therefore, in this comprehensive study, we investigated the expression, prognostic value, and functional roles of four recently identified DRGs (SLC7A11, SLC3A2, RPN1, and NCKAP1) across various cancers. Our results demonstrated that these DRGs were significantly upregulated in multiple tumor types and were associated with poor survival outcomes. Through mutation landscape analysis, we identified diverse missense mutations in these DRGs, with NCKAP1 exhibiting the highest mutation frequency (5.9% in skin cutaneous melanoma). Additionally, we observed positive correlations between these DRGs and tumor stemness (DNAss and RNAss) as well as RNA modifications, particularly m6A modification, in several cancer types. Furthermore, high expression of SLC7A11, RPN1, and NCKAP1 was positively associated with infiltration of T-helper type 2 (Th2) cells in various cancers, while high expression of SLC7A11, SLC3A2, and RPN1 correlated with tumor mutational burden (TMB) in 10, 4, and 8 tumor types, respectively. Utilizing a protein-protein interaction network, we identified the RHO GTPases Activate WASPs and WAVEs pathway as significantly enriched, suggesting the involvement of these DRGs in cancer-related signaling pathways. Collectively, our findings provide novel insights into the molecular mechanisms and clinical implications of DRGs in pan-cancer, highlighting their potential as biomarkers and therapeutic targets for cancer treatment.
Process Optimization of Vacuum Concentration of Karonda Fruit Juice Using Response Surface Methodology: Effects on Antioxidant Activity, Iron Content and Gcms Profile
Authors: S. Chinmayi A. , J. Suresha G. , X. Rosemary M. , K. Sadananda G. , R. Venugopalan , R. Vasudeva K. , B. Suresha K. , K Swamy G. S.
Published: April 2024

In the realm of fruit processing, karonda juice stands out for its elevated moisture levels, posing challenges in storage and transportation. This study presents a pioneer effort for concentration of karonda juice through optimizing the process parameters viz., temperature and time using central composite design (CCD) of response surface methodology (RSM) within rotary evaporator setup. Through ten experimental runs, variations were introduced, adjusting temperatures from 45 to 55°C and duration from 90 to 210 minutes. The results showcased the efficacy of vacuum concentration, reducing moisture content to 16.43% and significantly elevating total soluble solids (TSS) from 9.02 to 89˚B. Moreover, key nutrients experienced substantial increase: ascorbic acid surged from 3.79 to 14.66 mg per 100g, total phenolic content (TPC) soared from 100.74 to 386.97 mg GAE per 100g, total antioxidant activity (TAA) (FRAP) escalated from 76.74 to 328.10 mg AAE per 100g, anthocyanin content increased from 10.9 to 129.34 mg per 100g, and iron content rose from 39 to 150.54 mg per 100g. GC-MS profile elucidated compounds like Tetrahydrofuran, 3-Hydroxy-3-methylvaleric acid, 3-Hexen-2-one, Hydroperoxide and Octane. The optimization process, guided by RSM revealed the ideal parameters: 55°C for 150 minutes, marking a significant advancement in karonda concentration techniques.
Transcriptomic and Proteomic Spatial Profiling of Pediatric and Adult Diffuse Midline Glioma H3 K27-Altered, Reveals Region Specific Differences and Limited Overlap between mRNA and Protein
Authors: Damodharan Sudarshawn , Shireman Jack M. , Xie Elliot , Distler Emily , Kendziorski Christina , Dey Mahua
Published: April 2024

Diffuse midline glioma, H3 K27-altered (DMG-Alt) are highly aggressive malignancies of the central nervous system (CNS) that primarily affect the pediatric population. Large scale spatial transcriptomic studies have implicated that tumor microenvironmental landscape plays an important role in determining the phenotypic differences in tumor presentation and clinical course, however, data connecting overall transcriptomic changes to the protein level is lacking. The NanoString GeoMx™ Digital Spatial Profiler platform was used to determine the spatial transcriptomic and proteomic landscape in a cohort of both pediatric and adult H3 K27-altered DMG biopsy samples. Three fluorescently labeled antibodies targeting immune cells (CD45), epithelial cells (PanCK), tumor cells (H3 K27M) and a nucleic acid stain (SYTO-13) were used to establish regions of interest (ROI) for genomic and proteomic analysis. We found genetic alterations within the tumor which can be delineated across patient age and spatial location. We show that the H3 K27M mutation itself has a profound impact on tumor cells transcriptomics and interestingly we found limited fidelity between overall transcriptome and proteome. Our data also validate the previously described OPC like precursor signature at the proteomic level and reveal a special shift in the signature based on the local TME composition.
Spirulina supplementation and circuit resistance training (CRT) reduce serum Asprosin and appetite and improve energy balance in overweight and obese Men
Authors: Nakhaei Hossein , Mogharnasi Mehdi , Dehghani Karim , Mohammadi Mahdi , Ghasemi Elham
Published: April 2024

Purpose
The present study aimed to investigate the effects of eight weeks spirulina supplementation and circuit resistance training (CRT) on Asprosin, appetite and energy balance of overweight and obese men.
Methods
The present study is a single-blind randomized controlled trial. Sixty overweight and obese men (BMI > 25) were purposefully selected and randomly divided into equal four groups of training plus spirulina, training plus placebo, spirulina, and placebo. The participants of the training groups performed 12 movements with 40–90 percent maximal repetition (3 sessions per week) and supplemental groups consumed 1000 mg of spirulina per day for eight weeks. Asprosin, appetite with visual analogue scales, calorie intake, energy expenditure and mass of body fat (MBF) were measured before and after intervention. To analyze data, one-way variance, paired- t-tests and Pearson correlation test was used by SPSS (version 20) at a significance level of p ≤ 0.05.
Results
After intervention Asprosin level, weight, MBF, calorie intake, and hunger declined and fullness and satiety increased in training plus spirulina, training plus placebo, and spirulina groups (p < 0.05). In addition, energy expenditure increased only in the training groups (P = 0.01). The mean changes of the research indicators in the training plus spirulina group were significantly more than the other groups (p < 0.05).
Conclusion
It seems that eight weeks of CRT and spirulina supplementation decrease the level of Asprosin and improve appetite and energy balance in overweight and obese people.
Well-being amid (im)mobility struggles: Youth’s experiences in Casamance, Senegal
Authors: Debray Alix , Petit Véronique , Ruyssen Ilse , Sow Ndiémé , Toma Sorana
Published: April 2024

Background Large numbers of young people worldwide, especially in the Global South, wish to migrate but lack the capacity to do so, with potentially detrimental consequences for their well-being and mental health. Termed ‘involuntary immobility’, this phenomenon is numerically larger than migration, but remains for now a largely underexplored area of research. Focusing on young Senegalese living in Casamance, this paper contributes to the limited literature on the implications of immobility for subjective well-being. It does so by (i) considering different degrees and types of involuntary immobility and their intersections, (ii) laying out the implications of (interacting) social and spatial immobilities for well-being with particular attention to youth’s agency in navigating a lack of capabilities, and (iii) by accounting for heterogenous experiences taking a gendered approach.
Methods For this study, 35 semi-structured interviews were conducted with 18- to 39-year-olds in Ziguinchor region, recruited through purposive and snowball sampling. Thematic analysis was employed on verbatim transcriptions of audio-recorded interviews.
Results Our study reveals a nuanced reality where aspirations to (temporarily) move abroad coexist with aspirations to stay in Casamance. Participants’ life aspirations and overarching projects clash, however, both with a lack of capabilities to move abroad and to enact these locally. This pervasive immobility decreases life satisfaction and generates negative emotions, such as stress, anxiety, discouragement, and distress. Despite these obstacles, our findings also underscore the agency and resourcefulness displayed by the youth as they navigate their limited control over life choices and paths.
Conclusions Involuntary spatial immobility exacerbates the dominant experience of social immobility, magnifying its effect on youth’s well-being, revealing a previously unacknowledged phenomenon. Our findings further emphasize the pressing need for a more cohesive alignment between migration policies and information campaigns on one hand and the real experiences and challenges encountered by their intended audience on the other.