bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Green Message Types on Advertising Effectiveness for Luxury and Budget Hotel Segments
Authors: Sahin Safak , Baloglu Seyhmus , Topcuoglu Esra
Published: December 2019

This study aims to broaden knowledge about the effects of green (environmentally responsible) advertising images on consumer behavior in the context of the hotel industry. A 5 (ad type: non-green vs. green with text vs. green with logos vs. green with visuals vs. green with the combination of all) × 2 (hotel segment: luxury vs. budget) between-subjects experimental design was developed. The purpose of this research, within the foundations of dual coding theory, is to investigate the influence of different types of green (textual, visual, green certification logos, and combination of all) versus non-green ads on advertising effectiveness operationalized as attitude toward the ad (AAd), attitude toward the hotel (AHot), and purchase intention (PI) for budget and luxury hotel segments while controlling the effects of environmental involvement. The results demonstrate that green text, green certification logo, green with visual cues, and green combination ads were more effective than non-green ads in terms of AAd, attitude toward the brand, or PI. The study also reveals that the effectiveness of green hotel ads will vary with the budget and luxury hotels as the results provide encouraging results for luxury hotels to increase ad effectiveness via using green certification in their advertising strategy. Overall, the findings provide implications for budget and luxury hotels in terms of designing green and sustainability messages in their communication strategies.
De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course
Authors: Ramachandran Preethi , Sahni Sonu , Wang Jen C.
Published: December 2019

The gastrointestinal tract is a common extranodal site for lymphomas. However, primary gastrointestinal lymphomas are rare. Diffuse large B-cell lymphomas (DLBCL) are the most commonly encountered type in the gastrointestinal tract. Most of the DLBCL are CD5 negative. CD5+ DLBCL is very rare and a poor prognostic subtype of lymphoma. We report a rare case of primary small bowel CD5+ DLBCL that evolved from being a localized low International Prognostic Index–scored disease into an advanced and aggressive disease primarily dictated by the presence of CD5 antigen positivity.
Pediatric Resident Attitudes Toward Inpatient Immunization of Children and Adolescents: Highlighting Differences in Human Papillomavirus Vaccination
Authors: Pfaff Nora , Garnett Chelsea , Mihalek Alexandra J. , Mamey Mary Rose , Wu Susan
Published: December 2019

Over a decade after its debut, human papillomavirus (HPV) vaccine coverage remains suboptimal. The inpatient setting presents a largely unexplored opportunity to increase vaccination rates. This study aims to describe pediatric resident attitudes toward inpatient immunization and compare differences by vaccine, in particular HPV. An anonymous survey of beliefs and practices regarding inpatient vaccines was distributed to pediatric resident physicians at a single freestanding urban children’s hospital in September 2017. A total of 58 surveys were collected (64% response rate). We found that pediatric residents were more likely to report that they never or rarely discuss the HPV vaccine during hospitalization compared with the primary childhood series ( P = .001), Tdap ( P = .02), and the influenza vaccine ( P < .001), and rarely offer the HPV vaccine during hospitalization compared with childhood vaccines ( P = .003) and influenza ( P = .001). This suggests that provider hesitancy still exists for the HPV vaccine, presenting opportunities for further education and inpatient interventions.
The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease
Authors: Srinagesh Hrishikesh K. , Özbek Umut , Kapoor Urvi , Ayuk Francis , Aziz Mina , Ben-David Kaitlyn , Choe Hannah K. , DeFilipp Zachariah , Etra Aaron , Grupp Stephan A. , Hartwell Matthew J. , Hexner Elizabeth O. , Hogan William J. , Karol Alexander B. , Kasikis Stelios , Kitko Carrie L. , Kowalyk Steven , Lin Jung-Yi , Major-Monfried Hannah , Mielke Stephan , Merli Pietro , Morales George , Ordemann Rainer , Pulsipher Michael A. , Qayed Muna , Reddy Pavan , Reshef Ran , Rösler Wolf , Sandhu Karamjeet S. , Schechter Tal , Shah Jay , Sigel Keith , Weber Daniela , Wölfl Matthias , Wudhikarn Kitsada , Young Rachel , Levine John E. , Ferrara James L. M.
Published: December 2019

Key Points

The MAGIC algorithm probability, computed from 2 serum biomarkers, predicts mortality in all GVHD grades after 4 weeks of treatment. Dynamic changes in the MAGIC algorithm probability occur within all biomarker risk groups and can guide therapy.
Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes
Authors: Huang Qiang , Hou Jue , Yang Peng , Yan Jun , Yu Xiaoliang , Zhuo Ying , He Sudan , Xu Feng
Published: December 2019

Background

HSV-1 is a common pathogen that infects 50–90% of the human population worldwide. HSV-1 causes numerous infection-related diseases, some of which are severely life-threatening. There are antiviral medications with activity against HSV-1. However, with the emergence of drug-resistant mutant strains of HSV-1, there is an urgent need to develop new effective anti-HSV-1 agents.

Methods

Therefore, we screened a chemical library of approximately 1500 compounds to identify inhibitors of HSV-1-induced toxicity for further drug development. Moreover, we performed several experiments, including western blot analysis, Q-PCR analysis and luciferase activity assay, to explore the antiviral mechanism of the candidates.

Results

Here, we identified a small molecule, mitoxantrone dihydrochloride, with potency against HSV-1-induced toxicity. Furthermore, the viral titers and expression levels of HSV-1 viral proteins were potently reduced by the presence of MD in many cell lines. Using Q-PCR analysis, we found that MD efficiently reduced the transcription of viral genes that are essential for DNA synthesis, namely, UL5, UL9, UL29, UL30, UL42 and UL52. Notably, MD also significantly inhibited the transcription of the immediate early genes ICP0, ICP22, ICP27 and ICP47, all of which are required for the expression of early and late viral gene products. Using immunofluorescence and western blot analysis, we found that the antiviral effect of MD was independent of the activation of the NF-κB and MAPK pathways. Furthermore, we found that the reduction in the transcription of viral immediate early genes was not related to the promoter activities of ICP0.

Conclusions

Therefore, the identification of compound MD as an inhibitor of toxicity induced by HSV-1 highlights its potential use in the development of novel anti-HSV-1 drugs.
A case report of two siblings with Alstrom syndrome without hearing loss associated with two new ALMS1 variants
Authors: Shurygina Maria F. , Parker Maria A. , Schlechter Catie L. , Chen Rui , Li Yumei , Weleber Richard G. , Yang Paul , Pennesi Mark E.
Published: December 2019

Background

Alström syndrome (AS) is a rare monogenic disorder characterized by progressive multi-organ pathology including retinal degeneration, hearing impairment and type 2 diabetes. Here we present clinical features in two siblings diagnosed with Alström syndrome associated with two novel changes in ALMS1.

Case presentation

Two siblings originally diagnosed as having achromatopsia presented with mild light sensitivity, nonspecific otitis media, and mild developmental delay during the first decade of life with a relatively stable ocular appearance during second decade, late onset of nystagmus and dyschromatopsia (after 20 years) and preserved vision during the third decade of life. One sibling had late onset hearing loss and both siblings had symmetric high myopia, normal stature, and ptosis. Clinical findings revealed structural and functional tests consistent with a cone-rod dystrophy. Novel variants c.9894dupC (p.S3298 fs) and c.10769delC (p.T3590 fs) in ALMS1 gene were found.

Conclusions

Two North American siblings who presented with a mild clinical phenotype of Alström syndrome were found to have novel mutations in ALMS1. These two frame-shift mutations segregated with the disease phenotype lending evidence to their pathogenicity.
The maternal antibody against diphtheria, tetanus and pertussis showed distinct regional difference in China
Authors: Meng Qinghong , Qian Qinghui , Li Li , Liu Dandan , Gao Wei , Yuan Lin , Yao Kaihu
Published: December 2019

Background

Passive transferred antibodies to the fetus play an essential role on protecting neonates and young infants until infant vaccination is more efficacious. However, very little is known about the discrepancy of DTP vaccine associated antibodies level in neonates from different economic areas in China.

Methods

In 2018, 200 neonates hospitalized in Shunyi Women and Children’s Hospital in Beijing, and 238 neonates hospitalized in Qianjiang Central Hospital located in the southwestern mountainous areas were included in this study. Antibodies specific for the antigens covered by DTP vaccine were determined using ELISA Kits (Euroimmun, Lübeck, Germany). The cut off value of ≥0.1 IU/ml (anti-diphtheria, anti-Dtx), > 0.1 IU/ml (anti-tetanus, anti-Ttx) and > 40 IU/ml (anti-pertussis toxin, anti-Ptx) were used to assess the percentage of protected neonates, respectively.

Results

The antibody levels in the neonates from Qianjiang (0.04 IU/ml for anti-Dtx IgG and 0.07 IU/ml for anti-Ttx IgG) were significantly lower than those from Shunyi (0.12 IU/ml for anti-Dtx IgG and 0.18 IU/ml for anti-Ttx IgG). The prevalence of protective anti-Dtx and anti-Ttx IgG were lower in the neonates from Qianjiang (7.1% for anti-Dtx IgG and 7.6% for anti-Ttx IgG) than in those from Shunyi (30.5% for anti-Dtx and 38.5% for anti-Ttx). The neonates from Qianjiang also had lower detectable rate of anti-Dtx (57.5%) and anti-Ttx IgG (55.8%) than neonates from Shunyi (97.5% for anti-Dtx and 71.0% for anti-Ttx). However, the detectable rate of anti-Ptx IgG in neonates from Qianjiang (39.9%) was higher significantly than in those from Shunyi (30.5%). Two neonates from Qianjiang have anti-PT IgG ≥100.0 IU/ml, which suggested that their mothers have a recent pertussis course.

Conclusions

The regional discrepancy of the protective antibody rates might be caused by different vaccine coverage and pertussis exposure, which suggested the importance of Tdap booster immunization for pregnant women or women at childbearing age, those living undeveloped areas in particular.
The incidence of bone marrow oedema at the sacroiliac joints in a non-rheumatological population — a retrospective cohort study
Authors: Nygaard A. , Jurik A. G. , Lund C. , Schiøttz-Christensen B.
Published: December 2019

Background

The purpose of this study is to determine the incidence of bone marrow oedema (BME) at magnetic resonance imaging (MRI) of the sacroiliac joints (SIJ) in a non- rheumatological population, and to explore whether patient-reported outcome measures are suitable for predicting BME at the SIJ at referral. Furthermore, to investigate the final clinical diagnoses three months after initial SIJ MRI.

Methods

This study was a retrospective cohort study consisting of patients 18–45 years of age that were referred for a SIJ MRI between 1 July 2016 to 30 June 2017 at the Department of Radiology in Lillebaelt Hospital, Denmark. The SIJ MRI radiological reports were evaluated for signs of BME. Principal and secondary diagnoses according to the 10th version of International Classification of Diseases (ICD-10)—three months after the initial MRI—were identified in the electronic patient record system. For a subgroup of patients, patient- reported outcome measures, such as the 23-item Roland Morris Disability Questionnaire, quality of life and pain intensity in the back and leg were included from the local SpineData database.

Results

In total, 333 patients were included, and 187 (56.2%) of those patients received a final diagnosis within three months after the SIJ MRI. BME was detected in 63 (18.9%) patients; 17 (9.1%) patients had both BME at SIJ MRI and were diagnosed with spondyloarthritis (M45/M46). There was no statistically significant difference between patients with and without BME regarding demographics, quality of life, pain descriptions or function.

Conclusions

The incidence of BME in the cohort correlates well to previous studies regarding the incidence of SIJ MRI changes in non-rheumatological populations in Denmark. Patient-reported outcome measures do not seem to contribute to identifying patients with early-phase BME in a non-rheumatological population.
iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity
Authors: Diaz Bessone María Inés , Simón-Gracia Lorena , Scodeller Pablo , Ramirez María de los Angeles , Lago Huvelle María Amparo , Soler-Illia Galo J. A. A. , Simian Marina
Published: December 2019

Background

Tamoxifen (Tam) is the most frequent treatment for estrogen receptor (ER) positive breast cancer. We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. With the aim of developing a nanoformulation that would simultaneously tackle ER and FN/β1 integrin interactions, we designed polyethylene glycol-polycaprolactone polymersomes polymersomes (PS) that carry Tam and are functionalized with the tumor-penetrating iRGD peptide (iRGD-PS-Tam).

Results

Polyethylene glycol-polycaprolactone PS were assembled and loaded with Tam using the hydration film method. The loading of encapsulated Tam, measured by UPLC, was 2.4 ± 0.5 mol Tam/mol polymer. Physicochemical characterization of the PS demonstrated that iRGD functionalization had no effect on morphology, and a minimal effect on the PS size and polydispersity (176 nm and Pdi 0.37 for iRGD-TAM-PS and 171 nm and Pdi 0.36 for TAM-PS). iRGD-PS-Tam were taken up by ER+ breast carcinoma cells in 2D-culture and exhibited increased penetration of 3D-spheroids. Treatment with iRGD-PS-Tam inhibited proliferation and sensitized cells cultured on FN to Tam. Mechanistically, treatment with iRGD-PS-Tam resulted in inhibition ER transcriptional activity as evaluated by a luciferase reporter assay. iRGD-PS-Tam reduced the number of cells with self-renewing capacity, a characteristic of breast cancer stem cells. In vivo, systemic iRGD-PS-Tam showed selective accumulation at the tumor site.

Conclusions

Our study suggests iRGD-guided delivery of PS-Tam as a potential novel therapeutic strategy for the management of breast tumors that express high levels of FN. Future studies in pre-clinical in vivo models are warranted.
Renal function change after switching tenofovir disoproxil fumarate for tenofovir alafenamide in the HIV-positive patients of a metropolitan sexual health service
Authors: Turner Dane , Drak Douglas , O’Connor Catherine C. , Templeton David J. , Gracey David M.
Published: December 2019

Background

Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched from TDF. The factors which predict improved renal function in patients switching from TDF to TAF have yet to be described.

Aim

To determine which patient factors are associated with an improvement in renal function following the switch from a TDF- to a TAF-based HIV antiretroviral regimen.

Methods

A retrospective analysis was performed of a cohort from a publicly funded sexual health clinic in Sydney, Australia. All HIV-positive clinic patients switched from a TDF- to TAF-containing regimen between January 2016 and August 2018 were eligible for inclusion. Laboratory results were obtained from patients’ electronic medical records. The statistical significance of differences between pre- and post-switch means was determined by paired t-tests, adjusted for baseline values, and associations between continuous variables by univariate linear regression.

Results

79 patients met inclusion criteria. The majority were male (89%), with a median age of 44 years (IQR: 34.5 to 53). Patients had a mean pre-switch estimated glomerular filtration rate (eGFR) of 95 ± 2 mL/min/1.73 m2, and there was no significant change post-switch (p = 0.062). Pre-switch eGFR was a significant predictor of the magnitude of eGFR change after the switch (p < 0.001), but there was no significant association with age (p = 0.189), cumulative TDF exposure (p = 0.454) or baseline urinary protein to creatinine ratio (p = 0.814).

Conclusion

While there was no significant difference in mean eGFR, in patients switched from TDF to TAF, baseline eGFR was a significant predictor of the change in eGFR. This suggests that patients on TDF with poorer baseline renal function would benefit more from switching to TAF. Further study to explore this association is warranted.
Prophylactic antibiotic bundle compliance and surgical site infections: an artificial neural network analysis
Authors: Walczak Steven , Davila Marbelly , Velanovich Vic
Published: December 2019

Background

Best practice “bundles” have been developed to lower the occurrence rate of surgical site infections (SSI’s). We developed artificial neural network (ANN) models to predict SSI occurrence based on prophylactic antibiotic compliance.

Methods

Using the American College of Surgeons National Quality Improvement Program (ACS-NSQIP) Tampa General Hospital patient dataset for a six-month period, 780 surgical procedures were reviewed for compliance with SSI guidelines for antibiotic type and timing. SSI rates were determined for patients in the compliant and non-compliant groups. ANN training and validation models were developed to include the variables of age, sex, steroid use, bleeding disorders, transfusion, white blood cell count, hematocrit level, platelet count, wound class, ASA class, and surgical antimicrobial prophylaxis (SAP) bundle compliance.

Results

Overall compliance to recommended antibiotic type and timing was 92.0%. Antibiotic bundle compliance had a lower incidence of SSI’s (3.3%) compared to the non-compliant group (8.1%, p = 0.07). ANN models predicted SSI with a 69–90% sensitivity and 50–60% specificity. The model was more sensitive when bundle compliance was not used in the model, but more specific when it was. Preoperative white blood cell (WBC) count had the most influence on the model.

Conclusions

SAP bundle compliance was associated with a lower incidence of SSI’s. In an ANN model, inclusion of the SAP bundle compliance reduced sensitivity, but increased specificity of the prediction model. Preoperative WBC count had the most influence on the model.
DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A
Authors: Hu Yang , Wu Fuxia , Liu Yankun , Zhao Qian , Tang Hua
Published: December 2019

Background

Emerging evidence indicates that dysregulation of microRNAs (miRNAs) contributes to cervical cancer (CC) tumorigenesis and development. Previous work showed that miR-484 which regulated the EMT process was obviously downregulated in CC. However, little is known about the precise mechanism.

Results

We found that the deficiency of EZH2-recruited DNA methyltransferases DNMT1 reduced the CpG methylation of miR-484 promoter and then increased the miR-484 expression. Furthermore, the cell membrane-bound matrix metalloproteinase (MMP14) and the hepatocyte nuclear factor 1A (HNF1A) were found to be downregulated by miR-484. miR-484 repressed the expression of MMP14 and HNF1A inhibiting CC growth and metastasis in vitro and in vivo. Upregulation of MMP14 and HNF1A promotes the CC cell adhesion and EMT, all of which contribute to cell motility and metastasis. Moreover, miR-484 negatively regulates the WNT/MAPK and TNF signaling pathway by downregulating HNF1A and MMP14 respectively. Thus, miR-484, who is downregulated by DNMT1-mediated hypermethylation in its promoter, functions as a tumor suppressor by inhibiting MMP14 and HNF1A expression in CC.

Conclusion

Our finding characterizes miR-484 as a key suppressive regulator in CC metastasis and reveals a DNMT1-mediated epigenetic mechanism for miR-484 silencing, expanding our understanding of the molecular mechanism underlying CC progression and metastasis.

Graphical abstract
Paraneoplastic pyoderma gangrenosum associated with adenocarcinoma of the rectosigmoid junction: a case report
Authors: Alassani Fousséni , Kassang Panawe , Amouzou Efoe-Ga , Tchangai Boyodi , Sakiye Kossi Abossisso , Darré Tchin , Saka Bayaki , Attipou Komla
Published: December 2019

Introduction

Pyoderma gangrenosum is a rare, idiopathic, inflammatory, neutrophilic dermatitis characterized by sterile skin ulceration. It can be associated with an underlying pathology, especially inflammatory bowel disease and hematological malignancies. Its association with a malignant pathology in the context of a paraneoplastic syndrome is more commonly described in hematological malignancies, with solid tumors being rare.

Case report

We report a case of a 39-year-old West African man with pyoderma gangrenosum that developed 6 months before the clinical expression of rectosigmoid junction cancer. The removal of the cancer resulted in the patient’s recovery.

Conclusion

Recurrent pyoderma gangrenosum lesions may be the expression of colonic adenocarcinoma in paraneoplastic syndrome and require colonoscopy, especially in at-risk patients.
Use of health outcome and health service utilization indicators as an outcome of access to medicines in Brazil: perspectives from a literature review
Authors: Arueira Chaves Luisa , de Souza Serio dos Santos Danielle Maria , Rodrigues Campos Monica , Luiza Vera Lucia
Published: December 2019

Background

To guarantee the right to health, the health system must also ensure access to medicines. Several financial arrangements to provide these technologies are implemented and range from the direct (either total or partial) to indirect payment by the patient, being necessary to evaluate its effect on access to medicines. However, to ensure access to medicines is not just about ensuring its availability, as this only materializes in its use. Thus, evaluation studies of interventions in access to medicines have been using indicators related to the health results and use of health services as its outcomes. Furthermore, as this relationship is not direct, it is important to critically assess the adequacy of these tools to measure this phenomenon and, additionally, the ability to use it in the Brazilian scenario. Therefore, this study sought to identify, describe, and analyze the use of these indicators as medicine access outcomes, through a review of the scientific literature.

Methods

An extensive literature review was done using a bibliographic database for a systematic review. The references were selected based on inclusion and exclusion criteria, and the indicators from the papers retained were analyzed using the parameters of validity, measurability, reliability, and relevance.

Results

We have analyzed over 12,000 references of which 30 references were included, describing the use of 49 health outcomes and health service use indicators. The majority reported the use of health service utilization measures. In our evaluation, the best indicators for assessing the effects of co-payment intervention on access are the ones aimed at specific populations or symptomatic health conditions in which the response to the therapeutic treatment is known and occurs in a short period of time. It was evident the lack of information on the indicators analyzed as well as the limitation of the Brazilian secondary databases for its calculation.

Conclusions

This research showed the variety and heterogeneity of the indicators used in scientific studies. The best indicators for access to medicines are sought to measure the use of health services for symptomatic health conditions that are quickly responsive to pharmacological treatment, while the indicators related to worker productivity loss was the most suitable for health outcomes.
Adjacent digit fingerprint white line count differences: a pointer to sexual dimorphism for forensic application
Authors: Taura Magaji Garba , Adamu Lawan Hassan , Asuku Abdullahi Yusuf , Umar Kabiru Bilkisu , Abubakar Musa
Published: December 2019

Background

Sex determination is one of the leading criterion in identification and verification of an individual. However, the potential roles of differences in adjacent fingerprint white line count (FWLC) in sex inference are not well elucidated in the literature especially among Hausa population. The study was conducted to determine sexual dimorphism and predict sex using adjacent digit FWLC difference (adj. DFWLCD) among Hausa population of Kano state, Nigeria.

Methods

The study population involved 300 participants. FWLC was determined from a plain fingerprint captured using live scanner. The formula for adj. DFWLCD of thumb and fifth digit is dR15 for right hand. The same applied for possible combination in cephalocaudal direction. Mann-Whitney andttests were used for comparison of variables between sexes. Binary logistic regression analyses were employed for determination of sex.

Results

We observed a significantly larger adj. DFWLCD in males compared with females in most of the digit combination. A significant sexual dimorphism was observed in most of the adj. DFWLCD involving ring digit in both right (dR14, dR24, and dR34) and left (dL14, dL24, and dL34). The best discrimination was observed in adjacent FWLC difference of second and fourth digits in both right and left digits (dR24 and dL24). This was further supported by stepwise logistic regression analyses.

Conclusion

The adj. DFWLCD exhibits sexual dimorphism. The best prediction potentials were found to be dR24 and dL24 for right and left hands respectively.
Clinical characteristics and in-hospital outcome of heart failure in women: a single center registry from Egyptian cardiac care unit
Authors: Badran Hala Mahfouz , Elgharably Marwa Ahmed , Faheem Naglaa
Published: December 2019

Background

This study represents figures from a cardiac care unit (CCU) of a university hospital; it describes an example of a tertiary academic center in Egypt and provides an epidemiological view of the female HF patients, their risk profile, and short-term outcome during hospitalization.

Results

It is a local single-center cross-sectional observational registry of CCU patients 1 year from July 2015 to July 2016. Patient’s data were collected through a special software program. Women with evidence of HF were thoroughly studied.

Among the 1006 patients admitted to CCU in 1 year, 345 (34.2%) patients were females and 118 (34.2%) had evidence of HF, whereas 661 (65.7%) were males and 178 (26.9%) of them had HF. Women with HF showed 11.7% prevalence of the total population admitted to CCU. 72.7% were HFrEF and 27.3% were HFpEF. Compared to men, women with HF were older in age, more obese, less symptomatic than men, had higher incidence of associated co-morbidities, less likely to be re-admitted for HF, and less likely to have ACS and PCI. Valvular heart diseases and cardiomyopathies were the commonest etiologies of their HF. Women had more frequent normal ECG, higher EF%, and smaller LA size. There is no difference in medications and CCU procedures. While females had shorter stay, there is no significant difference in hospital mortality compared to male patients.

Conclusions

Despite higher prevalence of HF in females admitted to CCU and different clinical characteristics and etiology of HF, female gender was associated with similar prognosis during hospital course compared to male gender.
NeuroChaT: A toolbox to analyse the dynamics of neuronal encoding in freely-behaving rodents in vivo
Authors: Islam Md Nurul , Martin Seán K. , Aggleton John P. , O’Mara Shane M.
Published: December 2019

There is a dearth of freely-available, standardised open source analysis tools available for the analysis of neuronal signals recorded in vivo in the freely-behaving animal. In response, we have developed a freely-available, open-source toolbox, NeuroChaT (Neuron Characterisation Toolbox), specifically addressing this lacuna. Although we have particularly emphasised single unit analyses for spatial coding, NeuroChaT also characterises rhythmic properties of units and their dynamics associated with local field potential signals. NeuroChaT was developed using Python and facilitates a complete pipeline from automation of analysis to producing and managing publication-quality figures. Additionally, we have adopted a platform-independent format (Hierarchical Data Format version 5) for storing recorded and analysed data. By providing an easy-to-use software package, we aim to simplify the adoption of standardised analyses for behavioural neurophysiology and facilitate open data sharing and collaboration between laboratories.
ПРОБЛЕМЫ ИСПОЛЬЗОВАНИЯ ИННОВАЦИЙ В ОБРАЗОВАТЕЛЬНЫХ СФЕРАХ
Authors: Preobrazhenskiy Andrey Petrovich , Choporov Oleg Nikolaevich
Published: December 2019

В данной статье обсуждаются особенности применения инноваций в образовательных процессах. Показана их роль как при усвоении знаний, так и при мотивации обучающихся.
РАСПРОСТРАНЕННОСТЬ ЭКСТРАГЕНИТАЛЬНЫХ ФАКТОРОВ РИСКА И ИХ ВЛИЯНИЕ НА НЕБЛАГОПРИЯТНЫЕ ИСХОДЫ БЕРЕМЕННОСТИ
Authors: Kurbanismailov Renat Badrudinovich , Narkevich Artem Nikolaevich , Vinogradov Konstantin Anatolyevich , Mironova Alena Andreevna
Published: December 2019

Цель. Изучение распространенности экстрагенитальных факторов и их влияния на риск развития неблагоприятных исходов беременности в Красноярском крае.Материалы и методы. Для изучения факторов риска неблагоприятных исходов беременности использованы данные перинатального мониторинга Красноярского края, который функционирует на базе Красноярского краевого медицинского информационно-аналитического центра. В анализ включены данные о 122 250 случаях беременности в период с 2014 по 2017 гг. Все анализируемые случаи беременности распределены на 2 группы: I группа – случаи беременности с неблагоприятными исходами (8 290 случаев), II группа – случаи беременности с благоприятными исходами (113 960 случаев). В работе проанализированы следующие факторы: наличие сахарного диабета, артериальной гипертензии и гипотензивного синдрома, хронической специфической инфекции, заболеваний почек, варикозной болезни, тромбозов и тромбофлебитов, заболеваний щитовидной железы и надпочечников, пороков сердца без нарушения кровоснабжения, травм и переломов, нарушений мозгового кровообращения и миопии у матери.Результаты. Результаты проведенного исследования свидетельствуют о том, что большинство факторов оказывают влияния на риск развития неблагоприятных исходов беременности. В наибольшей степени на данный риск оказывают влияние наличие положительной реакции на волчаночный антикоагулянт, сахарного диабета, артериальной гипертензии II и III степени тяжести у матери.Заключение. Использование информации о распространенности и влиянии экстрагенитальных факторов на риск развития неблагоприятных исходов беременности позволит наиболее эффективно осуществлять маршрутизацию беременных по уровням оказания медицинской помощи для снижения числа неблагоприятный исходов беременности. Полученные результаты свидетельствуют о том, что на риск развития неблагоприятных исходов беременности оказывает влияние довольно широкий спектр факторов. При этом каждый фактор оказывает различное по степени влияние на данный риск.
АЛКОГОЛИЗМ КАК УГРОЗА СОЦИАЛЬНОЙ БЕЗОПАСНОСТИ НАСЕЛЕНИЯ ВОРОНЕЖСКОЙ ОБЛАСТИ
Authors: Yakovenko Nataliya Vladimirovna , Fedotov Vladimir Ivanovitch , Mikhno Vladimir Borisovitch , Safonova Irina Vyacheslavovna
Published: December 2019

В условиях динамичности и неопределенности социальных процессов особую актуальность приобретают проблемы обеспечения безопасности, так как потребность в ней является базисным, мотивационным механизмом человеческой жизнедеятельности. Алкоголизм представляет собой комплекс медико-социальных патологий, которые крайне негативно влияют на нормальное функционирование российского общества. Эта проблема существует столько же, сколько существует само человечество. Однако именно в нынешних условиях нестабильности социально-экономических процессов и явлений она приобретает особую значимость. Алкоголизм представляет собой угрозу для социальной безопасности, так как наносит не только моральный, но социальный и экономический ущерб.Цель исследования: раскрыть проблему алкоголизации населения Воронежской области в контексте социальной безопасности.Материалы и методы. Основным методологическим подходом выступил системный, который дает возможность рассмотреть феномен алкоголизации населения в зависимости от внешних и внутренних факторов его возникновения, а также социальных изменений, обусловленных им.Результаты. Раскрыты основные тенденции, связанные с алкоголизмом в Воронежской области. Показаны динамика и тенденция заболеваемости алкоголизмом населения Воронежской области. Проведена классификация муниципальных образований региона по «территориям риска».Заключение. В современных условиях развития российского общества проблема социальной безопасности стоит очень остро. Алкоголизм выступает одной из угроз социального благополучия населения. Анализ ситуации в Воронежской области показывает необходимость разработки ряда мероприятий региональными органами власти с целью профилактики алкоголизации населения с учетом негативных, деструктивных последствий и угроз для социальной безопасности региона.
ASSOCIAÇÃO ENTRE OFERTA DE FÓRMULAS INFANTIS E CHUPETAS NA MATERNIDADE E AMAMENTAÇÃO NOS PRIMEIROS SEIS MESES DE VIDA
Authors: Silva Osvaldinete Lopes de Oliveira , Rea Marina Ferreira , Sarti Flávia Mori , Silva Milene De Oliveira
Published: December 2019

Introdução: Amamentação (AM) é base para a segurança alimentar e saúde. Deve ser promovida na maternidade por práticas como os passos 6 (não oferecer suplementos) e 9 (não oferecer bicos) da Iniciativa Hospital Amigo da Criança (IHAC). Objetivo: Avaliar o cumprimento dos passos 6 e 9 da IHAC e sua associação com a AM nos primeiros seis meses de idade. Metodologia: Coorte prospectiva em seis hospitais do município de São Paulo, sendo três Hospitais Amigos da Criança (HAC) e três não HAC. Mães foram entrevistadas na maternidade e por telefone aos 30 e 180 dias. Investigaram-se o cumprimento dos passos 6 e 9 e as práticas de AM. As associações foram analisadas por regressão logística ajustada para as variáveis de confusão determinadas pelo gráfico acíclico direcionado (DAG). Resultados: Amostra de 969 mães na primeira entrevista, 902 na segunda e 814 na terceira. Os passos 6 e 9 foram cumpridos nos dois grupos de hospitais. O não cumprimento do passo 6 reduziu o AME aos 30 dias (aOR=1,82; IC=1,19-2,77) e a AM aos 180 dias (aOR=1,79; IC=1,15-2,78). O descumprimento do passo 9 reduziu o AME aos 30 dias (aOR=2,33; IC=1,30-4,19). Conclusão: A chance do AME no primeiro mês foi reduzida pela oferta de fórmula infantil e chupeta na maternidade. Aos seis meses, a amamentação foi reduzida pela introdução de fórmula na maternidade. Os resultados reforçam a importância do cumprimento das disposições do Código Internacional de Comercialização de Substitutos do Leite Materno, propiciando um ambiente seguro que incentive a mulher a escolher amamentar.DOI: 10.12957/demetra.2019.43555
RELATO DE EXPERIÊNCIA: GRUPO DE APOIO AO ALEITAMENTO MATERNO DO MUNICÍPIO DE SÃO GONÇALO
Authors: Flor Rogéria Batista , Damm Denise Veigo , Almeida Aline Rodrigues , De Sousa Ana Paula Seixas , Fernandes Alexandre Guimarães
Published: December 2019

Trata-se de relato de experiência da construção e desenvolvimento de um grupo de apoio ao aleitamento materno que atua em uma Clínica da Atenção Primária à Saúde no município de São Gonçalo, RJ. O grupo atua com palestras, rodas de conversas, orientações e aconselhamentos sobre as questões da lactação. Constatou-se que o grupo é uma estratégia importante de educação em saúde, essencial para garantir a assistência integral e de qualidade para a gestante, bebê e família. Configura-se como uma excelente estratégia para acolher as gestantes e suas famílias e criar vínculos entre usuários e profissionais. Conclui-se que é importante assegurar a qualidade na assistência prestada à gestante, sendo fundamental desenvolver espaços de troca de experiências, de conhecimentos e de exercício da assistência interdisciplinar.DOI: 10.12957/demetra.2019.43743
Pacientes com traqueostomia: conhecimentos, atitudes e práticas das equipes do serviço de atenção domiciliar
Authors: Castro Mônica Cristina da Silva , Teixeira Luiz Antônio da Silva
Published: December 2019

O Programa Melhor em Casa é constituído pelas equipes do Serviço de Atenção Domiciliar inseridas em área territorial adscrita. Tem por objetivo melhorar e ampliar a assistência no SUS a pacientes com agravos de saúde, que possam receber atendimento humanizado, em casa, perto da família. Assim, a pesquisa teve por objetivo, identificar os conhecimentos, atitudes e práticas das equipes que compõe o serviço de atenção domiciliar, em relação ao processo de atenção à saúde dos pacientes com traqueostomia, internados no domicílio, no município de Macapá. Trata-se de um estudo descritivo, com abordagem qualitativa, realizado com dezessete profissionais que atuam no Serviço de Atenção Domiciliar. Os dados foram coletados por meio de entrevista semi-estruturada com uso de um roteiro e analisados através da técnica de análise de conteúdo proposta por Bardin. Utilizou-se também a análise de documentos oficiais e observação sistemática que possibilitou descrever os aspectos relacionados à dinâmica do serviço e das equipes. O estudo revelou que a estrutura disponível para a realização da atenção domiciliar é um ponto crítico e desfavorável comparado ao arcabouço teórico que o programa preconiza. Foi possível considerar o Melhor em Casa como um programa tronco, conectado com os demais programas assistenciais existentes dentro da oferta de serviços da atenção primária de saúde. Concluiu-se que o modelo de assistência que se propõe o programa coloca-se a favor de uma de assistência integral ao indivíduo, sendo de extrema importância a disponibilização de condições mínimas necessárias para a execução das práticas que ultrapassem o modelo tradicional de assistência à saúde.
COBERTURA DAS CAMPANHAS DE VACINAÇÃO ANTIRRÁBICA ANIMAL
Authors: Gebrim Murilo Stefan , Tobias Gabriela Camargo , Teixeira Cristiane Chagas
Published: December 2019

Objetivo: analisar a cobertura vacinal nas campanhas antirrábica em Senador Canedo, Goiás, Brasil, no período de 2012 a 2017. Materiais e métodos: estudo descritivo, sobre a cobertura de vacinação antirrábica. A população em estudo compreendeu todos os cães e gatos que foram vacinados no período de 2012 a 2017. As informações foram obtidas pelo DATASUS e os dados foram organizados e analisados em Programa Microsoft® Excel. Resultados: no período estudado a cobertura vacinal total do intervalo de 2012 a 2017 foi de 88,5% para cães e 88,1% para gatos. O ano de maior cobertura vacinal foi o de 2012 para cães e 2017 para gatos, com 112,2% e 105%, respectivamente, onde as metas estabelecidas foram ultrapassadas. Conclusão: diante da letalidade de 100% dos casos da raiva e o alto custo na assistência preventiva às pessoas expostas ao vírus, torna-se essencial o esforço das secretarias municipais de saúde para realizarem as campanhas vacinais para eliminação e controle deste agravo.
Empirical comparison between effective medium theory models for the dielectric response of biological tissue at terahertz frequencies
Authors: Hernandez-Cardoso Goretti G. , Singh Abhishek K. , Castro-Camus Enrique
Published: December 2019

We study the use of three effective medium theory models, namely Maxwell–Garnett, Bruggeman, and Landau–Lifshitz–Looyenga, for the dielectric response of biological tissue in the terahertz band of the electromagnetic spectrum. In order to accomplish our objectives, we performed measurements on water-dehydrated basil binary mixtures encompassing the entire concentration range, and we further analyze the dielectric function with the models. Our results indicate that the Landau–Lifshitz–Looyenga and Bruggeman models provide marginally better fit to the experimentally measured dielectric function in the terahertz band. We further discuss the biological relevance of the models in the context of our experimental data based on their fundamental assumptions.
A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease
Authors: Zhao Xuemei , Kang John , Svetnik Vladimir , Warden Donald , Wilcock Gordon , David Smith A , Savage Mary J , Laterza Omar F
Published: December 2019

Background

Accurate diagnosis of Alzheimer disease (AD) involving less invasive molecular procedures and at reasonable cost is an unmet medical need. We identified a serum miRNA signature for AD that is less invasive than a measure in cerebrospinal fluid.

Methods

From the Oxford Project to Investigate Memory and Aging (OPTIMA) study, 96 serum samples were profiled by a multiplex (>500 analytes) microRNA (miRNA) reverse transcription quantitative PCR analysis, including 51 controls, 32 samples from patients with AD, and 13 samples from patients with mild cognitive impairment (MCI). Clinical diagnosis of a subset of AD and the controls was confirmed by postmortem (PM) histologic examination of brain tissue. In a machine learning approach, the AD and control samples were split 70:30 as the training and test cohorts. A multivariate random forest statistical analysis was applied to construct and test a miRNA signature for AD identification. In addition, the MCI participants were included in the test cohort to assess whether the signature can identify early AD patients.

Results

A 12-miRNA signature for AD identification was constructed in the training cohort, demonstrating 76.0% accuracy in the independent test cohort with 90.0% sensitivity and 66.7% specificity. The signature, however, was not able to identify MCI participants. With a subset of AD and control participants with PM-confirmed diagnosis status, a separate 12-miRNA signature was constructed. Although sample size was limited, the PM-confirmed signature demonstrated improved accuracy of 85.7%, largely owing to improved specificity of 80.0% with comparable sensitivity of 88.9%.

Conclusion

Although additional and more diverse cohorts are needed for further clinical validation of the robustness, the miRNA signature appears to be a promising blood test to diagnose AD.
Quality Control of Preanalytical Handling of Blood Samples for Future Research: A National Survey
Authors: Gils Charlotte , Nybo Mads
Published: December 2019

Background

Assessment and control of preanalytical handling of blood samples for future research are essential to preserve integrity and assure quality of the specimens. However, investigation is limited on how quality control of preanalytical handling of blood samples is performed by biobanks.

Methods

A questionnaire was sent to all Danish departments of clinical biochemistry, all Danish departments of clinical immunology, the Danish Health Surveillance Institution and the Danish Cancer Society. The questionnaire consisted of questions regarding preanalytical handling of samples for future research. The survey was carried out from October 2018 until the end of January 2019.

Results

A total of 22 departments (78%) replied, of which 17 (77%) performed preanalytical quality control of the blood samples. This quality control consisted of patient preparation, temperature surveillance of freezers, maintenance of centrifuges, and visual inspection for hemolysis, lipemia, and sample volume. Automated sample check for hemolysis, icterus, and lipemia interferences was performed by 41% of respondents, not performed by 50% of respondents, and 9% did not answer. The majority (55%) of the participants stated that they had no local standard operating procedure for preanalytical handling of samples for research projects.

Conclusions

The preanalytical phase for blood samples obtained and preserved for future research in Denmark is highly heterogeneous, although many aspects (e.g., hemolysis, which also affects DNA analyses, metabolomics, and proteomics) seems highly relevant to document. Our findings emphasize the need to optimize and standardize best practices for the preanalytical phase for blood samples intended for use in future research projects.
Homero Aridjis. Antología Poética (1960-2018). Edición de Aníbal Salazar Anglada. Madrid: Cátedra, 2018
Authors: Abellán Chuecos Isabel
Published: December 2019

Reseña de la publicación: Homero Aridjis. Antología Poética (1960-2018). Edición de Aníbal Salazar Anglada. Madrid: Cátedra, 2018, 408 pp. ISBN: 9788437638959.
Pleonazmus és tautológia
Authors: Schirm Anita
Published: December 2019

A pleonazmus és a tautológia jelenségét a különböző nyelvészeti szakmunkák eltérően közelítik meg. Egyes retorikák szerint szinonim a két fogalom, s a meghatározásaik is tartalmaznak átfedéseket. Más munkák viszont a köztük lévő különbségre helyezik a hangsúlyt, s a pleonazmust hasonlóságon, míg a tautológiát azonosságon alapuló szószaporításnak tartják. Tanulmányomban a szakirodalom definícióinak az áttekintése után egy középiskolai tankönyv­korpusz elemzésének az eredményeit ismertetem, majd ötleteket adok arra, hogy a nyelvtantanításban hogyan lehetne a korábbi ismereteket felhasználva példák segítségével a diákok számára a hétköznapi helyzetekben is haszno­sítható módon megtanítani e két fogalmat. Ugyanis mind a pleonazmus, mind pedig a tautológia kötődik a nyelvhelyességhez, a kommunikációhoz, a sti­lisztikához, a retorikához, a szemantikához és a pragmatikához, vagyis számos kapcsolódási pont van az egyes tananyagokban a két fogalom megismerte­tésére. A tanulmányban amellett érvelek, hogy nem fölösleges fölöslegesnek tűnő szerkezeteket tanítani, mert a fölöslegesség látszata mögött számos, egyáltalán nem fölösleges nyelvhasználati stratégia húzódhat meg.
Irodalmi matézis
Authors: Büky László
Published: December 2019

Az irodalmi művekben ritka a matematikai vagy logikai fogalmak használata. Ismeretük műveltség vagy műveletlenség jelzésére, valamilyen szimbolikusság megjelenítésére alkalmas. Mint nyelvi elemek nagy hírértékűek, erős lehet stiláris hatásuk, amelyet jelöléseik (+, ‒, x, √, ∞ stb.) írásképe erősít.
Barragem do rio todos os santos no vale do mucuri/mg: análise de rompimento para Teófilo Otoni
Authors: Costa Alexandre Sylvio Vieira da , Silva Altamiro Junior Mendes , Colares Rodrigo Silva
Published: December 2019

Grandes obras da engenharia são projetadas para solucionar ou minimizar problemas. Neste trabalho é apresentado um estudo sobre a barragem que visa abastecer e satisfazer as necessidades da região, mas que podem gerar alguns transtornos caso o barramento se rompa. Desta forma a pesquisa avaliou as ondas de inundação provenientes do rompimento hipotético da barragem de Teófilo Otoni-MG. Para a realização deste estudo foi utilizado o método das características descrito por   Mascarenhas.  A vazão máxima de ruptura calculada resultou no valor de 5739,34 m³/s, utilizando o hidrograma triangular simplificado de ruptura. O tempo estimado de esvaziamento do reservatório é de aproximadamente 4.460,44 segundos (1,24 horas). Com base nos dados encontrados, percebemos que a sede municipal de Teófilo Otoni, situada a 15 km da barragem, seria atingida por um fenômeno de galgamento, cuja altura seria de aproximadamente três metros. Observa-se, neste desfecho, que os resultados obtidos no desenvolvimento dessa proposta de estudo, podem  ampliar  as  possibilidades  de  ações  relativas  à prevenção  de  catástrofes,  no  que  tange  à  construção, manutenção e rompimento involuntário de uma barragem de  contenção,  e  incentivar estratégias emergenciais  de  apoio,  em  caso  de  situações  de  risco iminente.