bluuebunny/crossref_metadata_2025 huggingface dataset:
Orofacial Functions and Chewing Effiency in Elderly Patients with Parkinson’s Disease Rehabilitated with Removable Prostheses
Authors: Massimo Corsalini , Biagio Rapone , Giovanni Cagnetta , Massimo Carossa , Pasquale Sportelli , Andrea De Giacomo , Alessandra Laforgia , Daniela Di Venere
Published: February 2020

Background:

Parkinson’s Disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. It is one of the movement disorders that can affect oro-facial conditions. It is more common in the elderly, having an average age of onset of around 60 years.

Objective:

The aim was to study orofacial functions in patients suffering from PD with partial or total edentulism, wearing removable prostheses.

Methods:

Forty-eight (48) elders, rehabilitated with removable dentures, were included: 24 patients suffering from Parkinson's disease constitute the Study Group (SG), and 24 subjects not suffering from Parkinson's disease or neurological degenerative diseases represent the Control Group (CG).

In SG, the severity of Parkinson's disease was assessed according to the Unified Parkinson's Disease Rating objective motor scale III, and oro-facial dysfunctions were evaluated using Nordic Orofacial Test-Screening (NOT-S). The duration of the use of dental prostheses expressed in years has been reported. In both the groups, the subjective chewing index for the analysis of masticatory ability and the two-color chewing gum test for the analysis of masticatory efficiency were conducted .

Results:

There was a statistically significant difference between the SG and CG compared to the NOT-S (P = 0.001).

Analyzing the study group, a statistically significant correlation was found between the masticatory efficiency and prosthetic years of use (rs = 0.436; P <0.05); instead, no statistically significant correlation was found between the masticatory efficiency and the severity of Parkinson's disease.

Conclusion:

In our study, we did not find differences between SG and CG in terms of the degree of masticatory efficiency; therefore, only a correlation between the duration of use of dental prostheses and the degree of masticatory efficiency was found.
Using Confirmatory Factor Analysis to Evaluate Construct Validity of the Indonesian Palatable Eating Motives Scale (I-PEMS)
Authors: Cahyani A.D. , Iskandarsyah A. , Cahyadi S. , Srisayekti W.
Published: February 2020

The purpose of this work is to establish the validity of the Indonesian Palatable Eating Motives Scale (I-PEMS) and to describe the characteristics in palatable eating motives among current Indonesian young adults. The Original Palatable Eating Motives Scale (PEMS) was translated into Indonesian and back-translated into English to confirm the conceptual and linguistic equivalence. The scale was administered to emerging adults aged 18-25 years old. Confirmatory factor analysis demonstrated that the I-PEMS has an acceptable factor structure. The result provided evidence of four factors of palatable eating motives. No significant difference from the I-PEMS score between males and females. The association was only observed between the scores of Conformity motive and Body Mass Index.
Phytochemicals from Citrus Limon Juice as Potential Antibacterial Agents
Authors: Singh Nitika , Jaiswal Jyotsna , Tiwari Priyanka , Sharma Bechan
Published: February 2020

Background:

Citrus limon(lemon) belongs to the Rutaceae family and has great therapeutic applications. The chemical ingredients ofC. limonhave been used in the formulation of several ethnic herbal medicines. The application of antibiotics has shown the development of drug resistance in antibacterial drugs. Due to the drug-resistant nature of microorganisms, there is an urgent need to develop a novel drug active against wildtype and MDR resistant strains of pathogens.

Aim:

The present study is an endeavor to characterize the juice ofC. limontowards its total antioxidants potential activity (FRAP), DPPH and antibacterial efficacy.

Methods and Materials:

The antimicrobial activity was evaluated using different bacterial species such asSalmonella typhi, Neisseria gonorrhoeae, Citrobacter species, Shigella flexneriandStaphylococcus epidermidis.

Results:

The results of the present study indicated the antibacterial potential ofC. limonfruit juice. Among the tested bacterial species,Shigella flexneridisplayed maximum inhibition followed by the other microbes such asStaphylococcus epidermidis, Citrobacter speciesandSalmonella typhi.

Conclusion:

These findings may be utilized in the development of cost effective, safe and efficient novel drugs active against several pathogenic multi drug-resistant microorganisms.
Hotspot Mutations in DICER1 Causing GLOW Syndrome-Associated Macrocephaly via Modulation of Specific microRNA Populations Result in the Activation of PI3K/ATK/mTOR Signaling
Authors: Klein Steven D. , Martinez-Agosto Julian A.
Published: February 2020

Background:

We have previously described mosaic mutations in the RNase IIIb domain
of DICER1that display global developmental delays, lung cysts, somatic overgrowth, macrocephaly
and Wilms tumor. This constellation of phenotypes was classified as GLOW syndrome. Due to the
phenotypic overlap between GLOW and syndromes caused by mutations in the PI3K/AKT/mTOR
pathway, we hypothesized that alterations in miRNA regulation of this pathway cause its specific
constellation of phenotypes.

Objective:

To test the hypothesis that DICER1 “hot spot” mutations associated with GLOW syndrome
activate PI3K/AKT/mTOR signaling.

Methods:

We developed HEK293T cells with loss of exon 25 in DICER1, a genetic modification that
is synonymous with the “hot spot” RNAseIIIb mutations that cause GLOW syndrome. We assayed
the cells for activation of the PI3K/AKT/mTOR signaling pathway.

Results:

We observed activation of the PI3K/AKT/mTOR pathway as demonstrated by increased
pS6Kinase, p4EBP1 and pTSC2 levels. Additionally, these cells demonstrate a striking cellular phenotype,
with the ability to form spheres when the serum is removed from their growth medium. The
cells in these spheres are Oct4 and Sox2 positive and exhibit the property of reversion with the addition
of serum. We queried miRNA expression data and identified a population of miRNAs that increase
due to these mutations and target negative regulators of the PI3K/AKT/mTOR pathway.

Conclusions:

This work identifies the delicate and essential role for miRNA control of the
PI3K/AKT/mTOR pathway. We conclude that the phenotypes observed in the GLOW syndrome are
the result of PI3K/AKT/mTOR activation.
Evaluation of the Antidepressant Like Activity of Ethanolic Extract of Calendula officinalis using Rodent Models (Wistar Rat) of Depression
Authors: Rajwinder Kaur , Singh Rajmeet , Lalit  , Jaswinder Kaur , Rajat
Published: February 2020

Background:

Depression disorder has been considered to be the global common psychological CNS disorder affecting about 121 million people worldwide and is among the leading causes of disability that not only inflicts suffering but also carries a high economic burden. Calendula officinalis L. (Marigold) is globally known for its medicinal importance containing various phytochemicals including terpenoids, quinones, coumarins and other constituents, showing some important biological activities like immuno-stimulant, hepatoprotective, antioxidant, etc. activities with no toxic effect.

Objective:

This study aims to evaluate the antidepressant effect of ethanolic extract of Calendula officinalis using rodent models (Wistar rat) of depression.

Material and methods:

The present study was carried out to evaluate the antidepressant effect of ethanolic extract of Calendula officinalis in Wistar rat. This effect was determined by recording the immobility time in Forced Swim Test (FST) and a number of squares crossing and rearing in Open Field Test (OFT). The rats were randomly divided into 5 groups. Rats belonged to group 1 act as control group and group 2 were given Imipramine (10 mg/kg, i.p.) which act as standard group.Wistar rats were treated i.p. with Ethanolic extract of Calendula officinalis group 3, 4 and 5 were given 100mg/kg, 200mg/kg and 400mg/kg respectively.

Results:

The effect of rat model of depression i.e. Forced Swim Test (FST) and Open Field Test (OFT) model indicated that Ethanolic extract of Calendula officinalis showed potent to moderate antidepressant effect (decrease in immobility time and increase in number of square crossing and rearing) as compared to normal group. The drug might act as monoamine oxidase inhibitors.

Conclusion:

Taken all together, the present study concluded that the drug EECO was to exert antidepressant effects by inhibiting the monoamine oxidase-A (MAO-A) reaction, which is responsible for the regulation of the metabolism of the neurotransmitter 5-hydroxytryptamine (5-HT) in the brain. This drug might act as monoamine oxidase inhibitors (MAO-inhibitors) hence may increase the levels of norepinephrine, dopamine and serotonin; and decrease the levels of GABA in the brain.
Naturally Available Nitrogen-Containing Fused Heterocyclics as Prospective Lead Molecules in Medicinal Chemistry
Authors: Bhardwaj Nivedita , Pathania Akashdeep , Kumar Pradeep
Published: February 2020

Heterocyclic compounds constitute one of the largest and most versatile families
of organic compounds. There are many heterocyclic compounds that are being isolated from
natural sources and day by day the number is increasing rapidly due to their enormous utility.
Nitrogen containing heterocyclic compounds have a prominent role in medicinal chemistry,
biochemistry and other streams of science. In this review, we have covered most of the
biologically active nitrogen containing heterocyclic compounds obtained from the natural
sources including indole, carbazole, quinoline, isoquinoline and benzothiazole ring system.
These isolated nitrogen containing heterocyclic compounds render wide spectrum of biological
activities including antifungal, anti-inflammatory, antibacterial, antioxidants, anticonvulsant,
anti-allergic, herbicidal and anticancer activities.
The Interactions Between Alzheimer’s Disease and Major Depression: Role of Ca2+ Channel Blockers and Ca2+/cAMP Signalling
Authors: Bergantin Leandro Bueno
Published: February 2020

Background:

The interactions between Alzheimer’s Disease (AD) and major depression
can be translated into clinical data showing that depressive patients have had an enhanced risk for
developing AD (later in life). The cellular mechanisms involved in these interactions remain under
intensive debate in the literature. In addition, the role of a Ca2+ homeostasis dysregulation in the
pathogenesis of neurodegenerative diseases, like AD, and major depression has been under intensive
discussion.

Objective:

Thus, revealing the interplay between AD and major depression may provide novel insights
into the pathogenesis of these diseases.

Methods:

Publications involving Ca2+ signalling pathways, AD, and major depression (alone or
combined) were collected by searching multiple databases to find the maximum number of relevant
citations (using a search strategy with high sensitivity for studies of etiology).

Results:

Ca2+ Channel Blockers (CCBs), classically prescribed for hypertensive patients, have been
demonstrating neuroprotective effects, such as decreasing the incidence of AD in hypertensive patients,
including alleviating major depression symptoms. A mechanism under debate is focused on the restoration
of the Ca2+ homeostasis. Indeed, previous studies of our own have correlated Ca2+ and cAMP signalling
pathways (Ca2+/cAMP signalling) in controlling both the neurotransmitter release and neuronal
death. These studies also observed that CCBs can affect Ca2+/cAMP signalling.

Conclusion:

This review discussed the plausible role of Ca2+/cAMP signalling in the neuroprotective
effects of CCBs, including the participation of Ca2+/cAMP signalling in the interactions between
major depression and AD. Considering both AD and major depression have become highly
prevalent medical problems in the world, the comprehension of the interactions between these diseases
could improve drug development.
MANAJEMEN PERUBAHAN ORGANISASI PUBLIK : MENGATASI RESISTENSI PERUBAHAN
Authors: Dewi Rosma Rosmala , Kurniawan Teguh
Published: February 2020

Organizational change is one thing that public organizations cannot avoid. A dynamic organizational environment and high public demands for good quality services make public organizations have to be able to adjust to change. But unfortunately the changes that occurred are not always well received, and in fact there is a resistance. Through a post positivist approach, this qualitative research seeks to analyze how public sector organizations are able to overcome the resistance of existing changes so that changes can be carried out properly and successfully achieve the desired goals. Analysis is done through literature review on several books, publications, reports or relevant news. The results of the analysis indicate that the resistance of public organizations can be avoided by the readiness of the organization to deal with changes and supported by all members of the organization, especially leaders as drivers who will bring the organization from the status quo towards the desired change. In the level of practice these efforts can be carried out by building the mental readiness of the apparatus to always be ready to face changes and be balanced with the government's ability to make responsive change policies.
Educação ambiental: a interpessoalidade a partir dos rios internos do ser humano
Authors: Gioria Andrea Pereyra , Albani Ionara Cristina , Podewils Tamires Lopes
Published: February 2020

Este artigo é resultado de um projeto de ação em Educação Ambiental que teve como objetivo geral, proporcionar à comunidade escolar, por meio da práxis, a reflexão e a reconstrução de posturas e de valores, possibilitando diferentes maneiras de compreender o lugar de pertencimento e constituindo distintas formas de relações. Como questionamento motivador, estabeleceu-se: o que está sendo feito para cuidar dos rios internos? Foi realizado com crianças da Educação Infantil e a comunidade escolar do Colégio Santa Teresinha, instituição pertencente à Congregação das Irmãs Escolares de Nossa Senhora. Observou-se, como principais resultados, a mudança de conduta com relação às ações, desenvolvendo uma compreensão social e, melhorando assim, as relações com o mundo. Ainda, o desenvolvimento de uma Educação Ambiental voltada para o progresso interpessoal do ser humano, resultou em mudanças individuais pertinentes ao bem coletivo, que refletiram de forma explícita nas relações do grupo.
A política de ensino médio integrado como garantia do direito à educação da juventude
Authors: Costa de Azevedo Mello Rachel Costa , Moll Jaqueline Moll
Published: February 2020

ResumoO presente artigo é uma pesquisa bibliográfica que tem por objetivo analisar a política de Ensino Médio Integrado à educação profissional como um caminho para a garantia do direito à educação da juventude e enfrentamento das desigualdades educacionais no contexto brasileiro. Realizamos uma discussão conceitual sobre o tema. Concluímos que o Ensino Médio Integrado busca enfrentar o dualismo que marcou praticamente todas as propostas e políticas públicas destinadas a esta etapa da escolarização, ao propor uma formação integrada, abrangendo um conjunto de conhecimentos que relacionam ciência, tecnologia, cultura e o mundo do trabalho, essencial para compreensão e inserção no mundo contemporâneo.Palavras-chave: ensino médio integrado; política em educação; direito à educação
A fecundidade da ecologia cosmocena na perspectiva do currículo e da dignidade humana
Authors: Pereira Vilmar , Freire Simone Grohs , Da Silva Márcia Pereira
Published: February 2020

O estudo aqui apresentado propõe pensar o currículo e a dignidade humana com base nas teses apresentadas pela Ecologia Cosmocena, acenando para uma nova compreensão da relação humanidade-natureza, reconhecendo que a era Antropocena, em que se avalia os impactos das atividades humanas como sendo determinantes na alteração ecológica do Planeta, já não consegue responder as necessidades deste tempo de crise. A reflexão sobre um currículo pautado nestas teses sugere um convite hermenêutico de reposicionarmos ações e escolhas que possam estabelecer outras relações humanidade-natureza. Mobiliza a refletir sobre a necessidade de ressignificar o princípio da dignidade a partir de uma compreensão do mundo que se habita para que os sentidos da existência humana sejam renovados num olhar compassivo pelo outro. Sobretudo convida a superação das dicotomias, injustiças e barreiras desumanizantes que, cunhadas por um capitalismo sem limites aumenta incertezas, descrenças e desumanidades.
CONCILIAÇÃO MATERNIDADE E TRABALHO: UM ESTUDO COM ALUNAS E SERVIDORAS DA UNIVERSIDADE FEDERAL DO TOCANTINS
Authors: Andrade Rayssa Neves , Iwamoto Helga Midori
Published: February 2020

O artigo teve como objetivo analisar as principais estratégias empregadas e dificuldades enfrentadas pelas estudantes e servidoras da UFT ao conciliar maternidade e trabalho. Trata-se de uma pesquisa qualitativa baseada na análise de conteúdo de Bardin, com dados demográficos tratados de forma quantitativa. Para a coleta de dados utilizou-se entrevistas semiestruturadas com 33 mães. Foram criadas dez categorias sendo discutidas conforme a fundamentação teórica. Os resultados indicam que com as mudanças nos tradicionais padrões familiares é possível essa conciliação, pois ser mãe é importante na vida dessas mulheres, mas o trabalho é uma fonte de realização pessoal
KEPENTINGAN POLITIK MASYUMI DALAM TAFSIR ANNUR KARYA TENGKU MUHAMMAD HASBI ASHSHIDDIEQY
Authors: Rahman Abd , Wulandari Suci
Published: February 2020

This study aims to look at aspects of Masyumi's political interests that sparked the spirit of the Islamic State in Annur's interpretation of Hasbi Ashshiddieqy. Using the socio-political analysis approach this study shows that Hasbi's interpretation in Annisa (4): 58-59 carries the political interests of the Masyumi which is aspired to the Islamic State. In this case Hasbi interprets that meant by ulu alamr in this verse is ahl halli wa alaqdi, the legislatif and eksekutif leaders according to the constitution at that time. Although carrying Islam as the basis of the state, Hasbi did not reject the meeting of Islamic teachings and Pancasila within the framework of the nation state. The interests carried by Hasbi are inseparable from his role as a reformist figure and Masyumi's representative in the constituents. This also confirms that a product of interpretation cannot be completely separated from the interests of the interpreter, it can even be a reflection of the political interests of its time
Individual Analysts' Stock Recommendations, Earnings Forecasts, and the Informativeness of Conference Call Question and Answer Sessions
Authors: Mayew William J. , Sethuraman Mani , Venkatachalam Mohan
Published: February 2020

This paper deepens our understanding of the anatomy of an earnings conference call. Prior research indicates that, on average, analysts providing bullish stock recommendations or beatable earnings forecasts benefit from greater access to corporate management. Therefore, we analyze whether and to what extent individual analysts' ex ante stock recommendations and earnings forecasts affect the information content of analyst-manager conversations. Using intraday absolute stock price reactions around specific analyst-manager dialogs to measure informativeness, we find that manager dialogs with bearish analysts whose forecasts are missed are more informative. Such analysts engage in longer conversations with more back-and-forth iterations and exhibit a more negative tone, relative to bullish analysts that provide beatable forecasts. Stock prices directionally respond to both the analyst's linguistic tone and the manager's voice pitch. In sum, the capital market effects during an earnings conference call are far more nuanced than previously documented.
Geometry of real objects in shipbuilding and ship repair
Authors: Lelyukhin Vladimir Egorovich , Kolesnikova Olga Valeryevna
Published: February 2020

The article considers the modern engineering practice of designing and manufacturing that uses various analytical and graphic forms representing geometric objects. Both of these forms are characterized by the presence of two problems in terms of production practice: 1 - tools of modern geometry cannot operate with non-ideal forms and configurations of material objects; 2 - lack of methods and tools for describing patterns of generating geometric objects, from production lines to the structure that characterizes the relative location of surfaces. The generalized provisions of the geometry of non-ideal objects theoretically justified for formal synthesis and their elements have been presented, which avoids problems of geometric configuration in the practice of designing and developing manufacturing technologies in shipbuilding and ship repair. A special toolkit based on discrete mathematics is proposed for the formal description of the geometric configuration of non-ideal objects. The principles of geometry of real objects describe the structural-parametric representation of objects in a six-dimensional space that is defined by linear and angular vectors. The concepts of linear and angular vectors are analyzed. It has been stated that the presence of an angular vector simplifies the perception and makes easier calculating the processes of geometric transformations. A geometrical object refers to a closed subspace bounded by a single surface, a set of mating or intersecting surfaces. The examples of the real plane deviations from its reference, location of the planes for creating the ideal geometric configuration, variants of real images, forming the basis for six-dimensional space, structure of geometric configurations have been illustrated. It has been found that any specific part acting as a geometric object can be represented by a set of surfaces and the structure of their relationships, which contributes to the correctness of its manufacture. The use of six-dimensional space allows to describe the spatial geometric configurations of parts of various mechanisms with mathematical accuracy.
Evaluation of influence of elastic properties of slide bearing of ship stern gear on stiffness coefficient
Authors: Khalyavkin Aleksey Aleksandrovich , Makeev Sergey Aleksandrovich , Loshadkin Dmitry Vladimirovich , Mamontov Victor Andreevich , Salamekh Ali  , Shatskov Denis Olegovich , Auslender Anna Yakovlevna
Published: February 2020

The article considers the ship shaft line as a complex dynamic system influencing the operation of the ship. There has been given a diagram of the shaft line with one stern bearing and one remote bearing of the propeller shaft. The shaft line service life depends on the material of the slide bearing of the stern gear (lignum vitae, babbitt, textolite, caprolon, bronze, polyurethanes, rubber). The analysis of the research of static and dynamic calculations of ship shafting has been carried out. The design scheme of the ship shafting on elastic point supports is presented. It has been referred to consider feasibility of the elastic and mechanical properties of stern bearings at the stage of designing a ship shaft line. The method of calculating the transverse vibrations of the shaft line is studied, the purpose of which is to determine the natural frequency. The formula for calculating the lowest natural frequency of bending vibrations is given. The results of experimental studies at the KMV-200 stand based on uneven distribution of loads along the stern bearings are considered. It has been suggested that the greater the wear, the lower the stiffness coefficient. At a certain degree of wear of stern bearings, a resonance phenomenon occurs at the lowest operating frequencies. The value of the stiffness coefficient is studied depending on the modulus of elasticity of the stern bearing material. Static analysis of the ship shaft line was made taking into account the stiffness coefficient of the stern bearing. The universal equation of the curved axis of the beam is used according to the initial parameters method. As it has been found, the greater the deflection at the propeller attachment point, the lower the natural frequency of the transverse vibrations of the shaft line. In calculations it is necessary to take into account the separation of the shaft line from the stern bearing, since it helps to reduce the natural frequency and the appearing resonance during transverse vibrations.
PROSES PARENTAL MEDIATION TERHADAP ANAK USIA PRASEKOLAH DALAM MENGGUNAKAN GADGET
Authors: Wulandari Herni , Santoso Meilanny Budiarti
Published: February 2020

ABSTRAK Gadget merupakan salah satu media yang digunakan oleh masyarakat Indonesia sebagai sumber informasi, hiburan dan pendidikan sehingga gadget dapat memberikan dampak yang postif dan negatif. Pemakaian gadget pada sekarang ini sudah digunakan mulai dari anak usia dini hingga orang dewasa. Persepsi efek positif anak terhadap gadget sangat penting untuk dikembangkan karena dapat membantu anak sebagai khalayak aktif untuk membedakan antara tontonan yang positif dan negative bagi anak.Dalam menggunakan g adget tentunya anak memerlukan dukungan dengan dilakukannya pendampingan dari orang tua untuk mengarahkan serta memberikan pemahaman-pemahaman mengenai media yang ditonton sehingga dapat meminimalisir dampak negatif. Pendampingan penggunaan media dan teknologi serta perangkatnya dikenal dengan istilah parental mediation . Tujuan dari penelitian ini yaitu untuk mengetahui bagaimana pengawasan orangtua (parental mediation) terhadap anak usia dini dalam menggunakan gadget . Metode penelitian yang digunakan dalam penelitian adalah kajian pustaka dan literatur yang berisi teori. Untuk menjawab permasalahan tersebut digunakan Teori Parental Mediation. Hasil dari kajian yang telah dilakukan terdapat tipe mediasi yang dilakukan orangtua untuk melakukan pengawasan terhadap anak usia prasekolah dalam menggunakan gadget yaitu mediasi restriktif (restrictive mediation), mediasi aktif (active mediation) , mediasi penggunaan bersama (co - use) ABSTRACK The gadget is one of the media used by Indonesian people as a source of information, education and education so that gadgets can have positive and negative impacts. The use of gadgets at this time has been used starting from early childhood to adults. Percepti on of positive effects of children on gadgets is very important to be developed because it can help children as active audiences to distinguish between positive and negative shows for children. In using gadgets, make sure children support by supporting the assistance of parents to support providing media supports watched so that it can minimize negative impacts. Assistance in the use of media and technology known as parental mediation. The purpose of this study is to learn how to supervise parents of early childhood using gadgets. The research method used in the research is lit e r a t u r e r e vie w a n d lit e r a t u r e w hic h c o n t ain s t h e o r y . T o a n s w e r t h e s e q u e s tio n s u s e t h e P a r e n t al Mediation Theory. Restrictive mediation (restrictive mediation), active mediation (activ e mediation), co - use mediation.
STRATEGI TANGGUNG JAWAB SOSIAL STARBUCK DALAM MEWUJUDKAN LINGKUNGAN YANG BERKELANJUTAN
Authors: Shidiq Alima Fikri , Purnama Fitri Hajar , Raharjo Santoso Tri , Humaedi Sahadi
Published: February 2020

ABSTRAK Pemerintah Indonesia berkomitmen untuk mewujudkan ke 17 tujuan SDG ini dengan melibatkan seluruh komponen masyarakat Indonesia mulai dari masyarakat itu sendiri, akademisi, pemerintahan hingga pihak swasta. Dengan melibatan pihak swasta dalam mewujudkan SDGs diharapkan akan membawa dampak lebih luas terhadap masyarakat, mengingat bahwa di Indonesia banyak terdapat perusahaan yang bergerak di bidang usaha pelayanan baik barang ataupun jasa kepada masyarakat Indonesia. Salah satu cara yang bisa dilakukan perusahaan dalam mewujudkan tujuan tersebut yaitu melalui program tanggung jawab sosial perusahaan (CSR). Hal ini ditanggapi positif oleh berbagai pihak, salah satunya Starbucks Coffee Company yang mengusung tujuan SDGs ke dalam program CSR (Corporate Social Responsibility) perusahaan. Sebagai green company Starbuck mengambil peran dalam pembangunan lingkungan berkelanjutan sebagai bentuk tanggung jawab sosialnya melalui program CSR yang diintegrasikan dengan strategi marketing. Adapun program CSR tersebut dilakukan baik secara langsung kepada masyarakat, bermitra dengan lembaga sosial ataupun kepada konsumennya.  ABSTRACT The Government of Indonesia is committed to realizing these 17 SDG objectives by involving all components of Indonesian society from the community itself, academics, government to the private sector. By involving the private sector in realizing SDGs, it is expected to have a wider impact on the community, given that in Indonesia there are many companies engaged in the business of providing goods or services to the people of Indonesia. One way companies can do in realizing thes e goals is through corporate social responsibility (CSR) programs. This was positively responded by various parties, one of which was Starbucks Coffee Company which brought the SDGs goals into the company's CSR (Corporate Social Responsibility) program. As a green company Starbuck takes a role in the development of environmentally sustainable as a form of social responsibility through CSR programs that are integrated with marketing strategies. The CSR program is carried out either directly to the community, in partnership with social institutions or to consumers.
Ciência do espaço sem espaço: disciplina Geografia e reforma do Ensino Médio no Brasil | Science of Space without Space: Geography discipline and High School reform in Brazil
Authors: Ribeiro Larissa Oliveira Mesquita , Ribeiro Willame De Oliveira
Published: February 2020

O objetivo deste artigo é analisar as implicações da reforma do Ensino Médio sobre a disciplina Geografia e os seus desdobramentos para a sociedade brasileira. Os procedimentos metodológicos utilizados são de natureza bibliográfica e documental, com destaque para as análises da Lei de Diretrizes e Bases da Educação (Lei n°9.394/1996) e da Lei n°13.415/2017, que disciplinou a reforma do Ensino Médio. Os resultados da pesquisa ressaltam que a disciplina Geografia compunha a estrutura curricular da Educação Básica brasileira mesmo antes da conformação da Geografia científica, com forte articulação com interesses estatais e elitistas, o que não se repete na atualidade, no âmbito da reforma do Ensino Médio, que promove a fragilização dessa disciplina na Educação Básica, representando um claro desacordo entre os poderes elitistas e os caminhos seguidos pela disciplina Geografia nos últimos anos. As implicações dessa reforma em relação à disciplina Geografia devem ocasionar, entre outras consequências, perdas na formação voltada à construção de um sujeito social complexo atuante no âmbito profissional e também em outras esferas da vida social.
Mudanças curriculares no Ensino Médio a partir da Lei n°13.415/2017: percepção de estudantes secundaristas | Curricular changes in High School Education from Law n°13.415/2017: Perception of High School Students
Authors: Reyes Lurvin Gabriela Tercero , Gonçalves Suzane Da Rocha Vieira
Published: February 2020

O presente artigo objetiva problematizar as mudanças curriculares que a Lei n°13.415/2017 impõe ao Ensino Médio brasileiro, assim como verificar a percepção que estudantes secundaristas, da Escola Estadual Dr. Augusto Duprat na Cidade do Rio Grande (RS), têm sobre essas mudanças. A base empírica foi construída a partir de uma investigação dissertativa de cunho qualitativo, contando com a participação de 61 alunos de 1º, 2º e 3º ano do Ensino Médio. Como procedimento para produção dedados, formaram-se 4 grupos focais, um com cada turmada escola; ademais, também foi aplicado um questionário fechado. Para a análise dos dados utilizou-se a metodologia de análise do conteúdo, a partir de 4 categorias estabelecidas a priori, sendo o presente trabalho produto de uma dessas categorias. A partir da análise dos dados, aponta-se um discurso reprobatório por parte dos estudantes, no que se refere à determinação de dispor de Língua Portuguesa e matemática como únicas disciplinas obrigatórias nos três anos de Ensino Médio. Os estudantes também discordaram da proposta de tornar uma percentagem do Ensino a Distância, afirmando que atualmente o ensino é precário e que essas disposições iriam fragilizá-lo ainda mais. Nas falas, identificou-se também uma associação da retirada de disciplinas como Filosofia e História com intenções governamentais de controlar a população. Por fim, considera-se fundamental que os jovens sejam ouvidos, visto que são os sujeitos do Ensino Médio os mais afetados com essas mudanças.
Trajetórias escolares no Ensino Médio Integrado: uma análise da atribuição de sentidos de jovens estudantes por meio da história oral temática | School trajectories in integrated High School Education: An analysis of the attribution of meanings of young students through thematic oral history
Authors: Zimmermann Tânia Regina , Socorro Anselmo Silva
Published: February 2020

Este artigo se insere na problemática dos desafios atuais do Ensino Médio brasileiro no que concerne à relação distanciada de muitos jovens frente à escola, marcada por tensão e altos índices de desistência dos estudantes. Nesta pesquisa entrevistamos 11 estudantes do Ensino Médio Integrado do Instituto Federal do Mato Grosso do Sul - Coxim, dos quais 4 foram selecionados para este artigo. A instituição foi selecionada por apresentar boa infraestrutura, docentes com alto nível de escolaridade e, em contraponto, altos índices de desistência escolar. O objetivo do estudo foi conhecer as trajetórias escolares dos jovens estudantes, bem como analisar os sentidos atribuídos à experiência escolar no Ensino Médio Integrado da instituição. As narrativas foram analisadas de forma descritiva, com base na metodologia da História Oral Temática, através da qual se estabeleceu um diálogo entre as falas dos estudantes e os interlocutores teóricos. Entre os estudantes desistentes, pôde-se observar a dificuldade de conciliação entre escola e trabalho, o desejo da independência financeira, a timidez e o excesso de reprovações. Também se observou trajetórias de êxito de estudantes ligados a iniciativas de ensino diferenciadas, embora com o reconhecimento do cansaço gerado pelas atividades escolares. Os resultados sinalizam a necessidade de ouvir e reconhecer as particularidades dos estudantes do Ensino Médio.
Reforma do Ensino Médio: retrocesso nas políticas educacionais brasileiras | High School Reform: Setback in Brazilian Educational Policies
Authors: Marcelino Angélica de Cássia Gomes , Porto Rita de Cassia Cavalcanti , Cabral Angela Ninfa Mendes de Andrade
Published: February 2020

O presente artigo é um ensaio que tem por objetivo refletir o contexto da reforma do Ensino Médio, implantada no Brasil por meio da Lei n°13.415/2017 e os seus impactos na formação docente, visando levantar discussões, estudos, diálogos e evidências que possam levar à reflexão acerca das políticas de formação dos professores vinculadas ao modelo de gerenciamento empresarial que vem sendo recentemente aplicado à educação. Constata-se, neste estudo, que essas políticas reformistas não estão comprometidas com a luta dos trabalhadores da educação e não propõem uma qualidade social. A reforma do Ensino Médio é vista neste estudo como um mecanismo de reprodução quando analisada à luz dos referenciais teóricos de Bourdieu e Passeron. Apontam-se, ainda, encaminhamentos que busquem o fortalecimento das estratégias de resistência dos profissionais docentes e a constante luta em prol do compromisso com as classes populares e/ou com quem precisar fazer uso da Educação Pública brasileira. A pesquisa se inspira na investigação temática, embasada em Freire, que se caracteriza pela leitura e análise crítica da realidade, bem como pela elaboração de propostas de ação, considerando que as políticas de formação docente deverão partir das necessidades dos educadores e da leitura crítica da realidade, a fim de que estes possam construir uma trajetória emancipatória, num processo permanente de reflexão-ação-reflexão.
Interação de agroecossistema consorciado com palma-sorgo em ambiente semiárido: uma revisão
Authors: Jardim Alexandre Maniçoba da Rosa Ferraz , Silva Thieres George Freire da , Souza Luciana Sandra Bastos de , Souza Marcondes de Sá
Published: February 2020

Em regiões áridas e semiáridas as condições climáticas e salinização do solo e da água proporcionam declínios na produção de forragem e comprometem o rendimento dos rebanhos. Logo, o uso de espécies forrageiras adaptadas e de alto valor nutricional, torna-se uma alternativa para manter a disponibilidade de alimentos em períodos sazonais. Dentre estas espécies, a palma forrageira é um alimento recomendado para os ruminantes, devido ao alto teor de água em suas estruturas, boa aceitabilidade e baixo custo de produção. A cultura do sorgo, também apresenta elevado potencial forrageiro, alta produção de matéria seca, baixa exigência hídrica, e adaptabilidade à consorciação, auxiliando em melhores produções em ambientes áridos e semiáridos. A utilização de sistemas consorciados acrescidos com a irrigação é de grande relevância para o manejo sustentável da pecuária local, uma vez que esse tipo de sistema maximiza o rendimento de forragem das áreas produtivas. Assim, objetivou-se com a presente revisão ressaltar a importância de estudos relacionados ao consórcio palma-sorgo em condições irrigadas no semiárido para subsidiar políticas de produção contínua de forragem. Os achados dessa revisão encorajam pesquisas no planejamento agrícola de área em ambientes negligenciados sob condições semiáridas com o consórcio de palma-sorgo para produção de forragem.
Motivation and ability to learn in relation to behavioural reactivity in horses
Authors: Ziemiańska Agnieszka
Published: February 2020

The aim of the study was to assess the relationships between the learning ability and other behavioural profile traits in horses and to answer the question whether motivation to undertake a specific task facilitates the problem solving process and influences the learning rate. The study involved 31 małopolska breed horses at various ages. The learning rate test consisted in moving or lifting the trough lid to achieve a reward. Additionally, all the horses were subjected to a series of behavioural tests. It was found that motivation to perform a specific task does not facilitate execution thereof and does not influence the speed of solving the problem. Similarly, the degree of horse’s arousal and the emotional reactivity do not exert an impact on the speed of solving the problem and are not associated with the motivation for activity in a specific situation.
دور الاقتدار المعرفي في تحقيق الابتكار التسويقي في عدد من المنظمات الفندقية في مدينة دهوك
Authors: Oso Khairy A.
Published: February 2020

يهدف البحث الى دراسة الاقتدار المعرفي ودوره في تحقيق الابتكار التسويقي في عدد من المنظمات الفندقية بمدينة دهوك ، منطلقا من مخطط فرضي يأخذ بنظر الاعتبار اتجاه العلاقة بين المتغيرين ، وتحقيقا لهدف البحث واكمال متطلباته باشر الباحث بأعداد اطار نظري بالاستفادة من ادبيات الموضوع ، واعتمد البحث المنهج الوصفي التحليلي ، وتم استخدام الاستبانة لاستطلاع اراء عينة البحث ، والمكونة من المديرين والذين بلغ عددهم ( 70 ) مديرا ، وتم استخدام بعض الأساليب الإحصائية لتحليل النتائج واختبار الفرضيات ، تمثلت اهم الاستنتاجات باهتمام المنظمات الفندقية بالاقتدار المعرفي ، واهتمامها بالابتكار التسويقي ، وتوصل البحث الى مجموعة من المقترحات من اهمها تعزيز الاهتمام بالمتغيرات المستقلة لكونها تساهم في تحقيق المتغير المعتمد.
Profil Kelengkapan Informasi oleh Apoteker tentang Cara Penggunaan Sediaan Handihaler® yang Mengandung Tiotropium Bromida Di Apotek Wilayah Surabaya Timur
Authors: Lorensia Amelia , De Queljoe Doddy , Tandjung Yessica Christina Wijaya
Published: February 2020

Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease that can be controlled with medication. Handihaler® may be an option in the control of COPD, but the use of techniques Handihaler® is lacking in patients can cause treatment to be not optimal, therefore, the role of pharmacists to explain how to use Handihaler®. This study aims to investigate the characteristics of how to use information given Handihaler® pharmacists in pharmacies in East Surabaya. This research is non-experimental research with cross sectional method, and using observation techniques in the form of a checklist. Sampling by non-random sampling method by using purposive. The data will be processed with descriptive statistical analysis. The research sample as many as 22 pharmacies. The results showed that the steps 1, 2, 3, and 4 can be explained properly, whereas no pharmacist to explain step 16. Therefore, community pharmacists need to increase knowledge to support the pharmacist's role in providing information on how to use inhalers to improve the effectiveness COPD therapy.
Evaluasi Karakteristik Fisik dan Uji Permeasi Pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon
Authors: Arifin Arfiani , Sartini Sartini , Marianti Marianti
Published: February 2020

Penelitian ini bertujuan mengetahui kombinasi perbandingan polimer etilselulosa dan PVP K-30 yang menghasilkan karakteristik fisik baik dan pengaruhnya terhadap permeasi kulit pada hewan coba. Pengujian yang dilakukan meliputi pengujian fisik yaitu uji organoleptik, kadar air, ketebalan, dan keseragaman bobot, serta uji permeasi kulit pada hewan coba menggunakan membran kulit tikus dan kelinci. Perbandingan formulasi etilselulosa dan PVP K-30  yang digunakan adalah 7:3 (F1), 8:2 (F2) dan 9:1 (F3). Patch dibuat dengan menggunakan metode solvent casting atau dikenal metode cetak tuang. Hasil penelitian menunjukkan bahwa kombinasi perbandingan polimer etilselulosa dan PVP K-30 yang menghasilkan karakteristik fisik baik adalah F2 (8:2) dan F3 (9:1). Berdasarkan hasil pengujian terhadap uji permeasi menggunakan membran kulit tikus dan kelinci dapat disimpulkan bahwa formula optimum yaitu F3 (9:1) dengan nilai permeasi tertinggi pada tikus 46,09% dan kelinci 66,30 %.
Reviuw Beberapa Bioaktivitas dan Senyawa Kimia Organisme Laut untuk Kefarmasian
Authors: Rijai Laode
Published: February 2020

The sea as a habitat for organisms, is very characteristic and extreme compared to the terrestrial environment. This extreme environment allows the metabolic processes of living things within to become characteristic and produce a number of secondary metabolites that are characteristic for defense. Secondary metabolites are certain compounds that are only possessed by certain orgasms, and these class of compounds are very valuable for pharmaceuticals such as raw materials for medicines, nutraceuticals, cosmetics, to medical devices. A number of types of compounds with biological activity very important for pharmaceuticals originating from marine organisms are (a) Cytotoxic activities sourced from Sinularin compounds, Crassin Acetate, Cytarabine, Fludarabine, Aplysistatin, Geranylhydroquinone, Asperidol (b) Cardiovascular activities for (i) Activities for Cardiotonic namely compounds Laminin, Octopamine, Saxitoxin, Autonomium Chlorides (ii) Activities for Hypotensive namely Spongosine, Doridosine, Aaptameine, Hymenin (c) Marine Toxin, namely compounds of the group Polytoxin, such as Palytoxin; Red Tide Toxin compounds such as Tetrodotoxin, Brevetoxin in the form of Pb Tx-1 and Pb Ts-1; and Ciguatera Toxin groups, namely Ciguatoxin (d) Antimicrobial Activity such as Zonarol, Prepacifenol, Polyhalo-3-Butene-2-one; Tetrabromo-2-heptanone; 2-Cyano-4,5-dibromopyrrole, Aeroplysinin (+) and (-); Eunicin (e) Activities for Antibiotics namely Okadaic Acid, Acanthfolicin, Norhalichondrin A; and (f) Active Miscellaneous for Pharmaceuticals, namely Latrunculin A and B; Kainic Acid, Domoic Acid, Vidarabine, Aplysinopsin, Barettin, Nereistotoxin and 28-Deoxyzoanthenamine compounds.
Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY
Authors: Saputri Ratih Dewi , Tjahjandarie Tjitjik Srie , Tanjung Mulyadi
Published: February 2020

One furokuinoline alkaloid, evolitrine (1), and one cinnamate acid, trans 3-methyl-4-geranil caffeic acid (2) were isolated from  the stem bark of Melicope hookeri.  The structures of both compounds were determined  based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their anticancer activity against murin leukemia P-388 cells, showing their IC50 were 4,06 ± 0,15 and 4,86 ± 0,30 µg/ml, and two compounds showed moderate activity.
Penetapan Kadar Total Flavonoid, Fenolat, dan Karotenoid, serta Uji Aktivitas Antioksidan dari Daun dan Kulit Batang Tanaman Kenitu (Chrysophyllum cainito L.)
Authors: Roni Asep , Fitriani Laela , Marliani Lia
Published: February 2020

Salah satu tanaman yang memiliki aktivitas antioksidan ialah kenitu (Chrysophyllum cainito L.) yang merupakan  famili sapotacea. Tanaman ini juga biasa digunakan masyarakat sebagai obat. Penelitian ini bertujuan untuk menetapkan kadar flavonoid, fenol serta aktivitas antioksidan pada daun dan kulit batang kenitu. Ekstraksi dilakukan dengan metode refluks bertingkat menggunakan tiga pelarut yang berbeda kepolarannya yaitu pelarut n-heksan, etil asetat dan etanol 96%. Penetapan  kadar  flavonoid dan fenol dilakukan dengan menggunakan spektrofotometri UV-Visibel. Pengujian aktivitas antioksidan dilakukan dengan menggunakan metode peredaman radikal bebas DPPH (1,1-Diphenyl-2-picryllhydrazil).  Hasil penetapan kadar menunjukkan kandungan flavonoid tertinggi terdapat pada ekstrak n-heksan daun (6,106 mg Qe/ 100 mg), kandungan fenol tertinggi terdapat pada ekstrak etanol daun (24,483 mg GAE / 100 mg ) dan kandungan karotenoid tertinggi terdapat pada ekstrak daun etil asetat (6,2386±0,0138 mg BE/100mg). Hasil pengujian aktivitas antioksidan menunjukkan ekstrak etanol daun kenitu memiliki aktivitas antioksidan paling kuat dengan nilai IC50  10,81 ppm.
Pengukuran Kualitas Hidup Pasien Pengguna Antihipertensi dengan European Quality of Life 5 Dimensions (EQ5D) Questionnaire dan Visual Analog Scale (VAS)
Authors: Yuswar Muhammad Akib , Susanti Ressi , Az-zahra Nadasyifa Shalihah
Published: February 2020

Hipertensi merupakan faktor risiko terjadinya diabetes melitus, stroke, osteoartritis dan gagal jantung. Hipertensi dengan dan tanpa komplikasi dapat menyebabkan penurunan kualitas hidup. Penelitian ini bertujuan untuk mengukur kualitas hidup pasien hipertensi dengan dan tanpa komplikasi agar dapat dilakukan pencegahan dan evaluasi kualitas hidup pasien hipertensi. Desain penelitian ini adalah observasional cross sectional. Pengambilan data dilakukan secara purposive sampling di Puskesmas Alianyang Kota Pontianak yang memenuhi kriteria inklusi dan eksklusi. Data dikumpulkan menggunakan European Quality of Life 5 Dimensions (EQ5D) Questionnaire dan Visual Analog Scale (VAS) pada 102 pasien hipertensi. Analisis data dilakukan dengan mengubah skoring EQ5D menjadi indeks EQ5D, menentukan mean/median nilai VAS serta dilakukan uji t. Diperoleh 26 pasien (25,49%) tidak memiliki masalah pada kelima dimensi dengan indeks EQ5D tertinggi. Dimensi yang paling banyak dimiliki pasien hipertensi dengan dan tanpa komplikasi adalah rasa sakit/tidak nyaman sebesar 63,72%. Kualitas hidup diukur menggunakan VAS diperoleh median 75. Hasil uji Mann-Whitney diperoleh tidak terdapat perbedaan kualitas hidup antara pasien hipertensi dengan dan tanpa komplikasi menggunakan VAS dan terdapat perbedaan kualitas hidup antara pasien hipertensi dengan dan tanpa komplikasi menggunakan EQ5D.