bluuebunny/crossref_metadata_2025 huggingface dataset:
Routine blood test markers for predicting liver disease post HBV infection: precision pathology and pattern recognition
Authors: Ajuwon Busayo I. , Roper Katrina , Richardson Alice , Lidbury Brett A.
Published: September 2023

Background

Early stages of hepatitis B virus (HBV) infection usually involve inflammation of the liver. Patients with chronic infection have an increased risk of progressive liver fibrosis, cirrhosis, and life-threatening clinical complications of end-stage hepatocellular carcinoma (HCC).

Content

Early diagnosis of hepatic fibrosis and timely clinical management are critical to controlling disease progression and decreasing the burden of end-stage liver cancer. Fibrosis staging, through its current gold standard, liver biopsy, improves patient outcomes, but the clinical procedure is invasive with unpleasant post-procedural complications. Routine blood test markers offer promising diagnostic potential for early detection of liver disease without biopsy. There is a plethora of candidate routine blood test markers that have gone through phases of biomarker validation and have shown great promise, but their current limitations include a predictive ability that is limited to only a few stages of fibrosis. However, the advent of machine learning, notably pattern recognition, presents an opportunity to refine blood-based non-invasive models of hepatic fibrosis in the future.

In this review, we highlight the current landscape of routine blood-based non-invasive models of hepatic fibrosis, and appraise the potential application of machine learning (pattern recognition) algorithms to refining these models and optimising clinical predictions of HBV-associated liver disease.

Outlook

Machine learning via pattern recognition algorithms takes data analytics to a new realm, and offers the opportunity for enhanced multi-marker fibrosis stage prediction using pathology profile that leverages information across patient routine blood tests.
Designing of the Health Information Model in Iranian Public Libraries
Authors: Joulahi Laleh , Hashemi-Madani Nahid , Sedighi Zeinab , Emami Zahra
Published: September 2023

This study aims to provide a health information model for public access to reliable and up-to-date information resources at public libraries. The study was based on a Sequential-Exploratory Mixed Methods Design and combination of qualitative and quantitative methods. Quantitative method was applied for 12 library managers in the health domain as well as officials of the institution of public libraries for whom in-depth and semi-structured interviews were applied. The third group (475 managers of the Iranian public libraries) participated in the quantitative survey. Quantitative results indicated the libraries’ space needs to be extended and the librarians require training courses about health information. Qualitative results, after coding, lead to extraction of ground theory. From the library managers’ point of view, for implementation of this model, a coherent planning and structured memorandum of understanding between public libraries and ministry of health is required. Finally, using the quantitative and qualitative results, the model of health information through public libraries in Iran has been extracted and presented. The present model includes three parts: management actions, strengthen resources, and education. It could be concluded that paying attention on information resources, especially in the field of health information, will lead to an increase in the level of awareness in the society, and consequently health status and quality of life of the people will improve. Thus, considering the variations in the referred people to the libraries, presentation of a health model in the field of health information in public libraries could be promising.
Highly efficient uptake of TcO4
−/ReO4
− by functionalized PAFs
Authors: Zhi Xupeng , Chen Xinlong , Shen Yinglin , Li Xiaomin , Yang Suliang , Zhang Shengdong
Published: September 2023

Selective removal of 99TcO4
− from complex radioactive wastewater is a challenging but meaningful task since it is important for both spent fuel reprocessing and 99TcO4
− leakage handling. Here, we synthesized a series of functionalized PAF-1 framework materials, PAF-1-C-N2, PAF-1-N2-C4, PAF-1-IM and PAF-1-PY, by grafting quaternary ammonium, imidazolium and pyridinium onto the PAF framework as active sites, respectively, which purpose is to screen functional groups with high affinity for TcO4
−. The structures and morphological characteristics of the four adsorbents were characterized by N2 adsorption-desorption, Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscope (SEM). These materials exhibit high selectivity for TcO4
−/ReO4
−, rapid adsorption kinetics (reaching equilibrium within 30 s), and a wide pH range (pH 3–11) for ReO4
−/TcO4
−adsorption. Among them, PAF-1-IM had the best adsorption performance, and the partition coefficient K

d
reached 1.27 × 106 mL/g. 97.1 % and 96.9 % of ReO4
− could be removed by PAF-1-IM even when the concentrations of PO4
3− and SO4
2− are 1000 times the concentration of ReO4
−, respectively. When the solid-liquid ratio is 10 g/L, 93.7 % of TcO4
− can be removed from the simulated Low Active Wastewater (LAW), which is higher than most other TcO4
− adsorbents. X-ray energy dispersive spectroscopy (EDS) and FT-IR suggest the adsorption process was anion exchange.
Guia para eleições eletrônicas na UFPel: Helios Voting UFPel
Authors: Leoneti Lencina Claiton , Cruz Matheus , Vieira Rodrigues Severo Renata , Costa de Moura Rodrigo
Published: September 2023

O sistema Helios Voting foi institucionalizado na UFPel em 2018 e usado pela primeira vez no Conselho de Planejamento da UFPel (COPLAN/UFPel). Em seguida à sua exitosa estreia, com grande participação, outras consultas universais organizadas pelo COPLAN serviram-se da ferramenta. Porém, o sistema ganhou maior atenção em 2020, por força da Pandemia da Covid-19, com a necessidade de manter os processos de eleição para diversos cargos de gestão e de representações em conselhos e órgãos colegiados. Assim, a Universidade ampliou o emprego do Sistema Helios Voting a partir de ações emergenciais, sempre com a condução direta da Pró-Reitoria de Planejamento e Desenvolvimento (PROPLAN). Foram conduzidos diversos processos com o mais absoluto sucesso, contribuindo diretamente para que na consulta informal para a escolha da reitoria na UFPel os organizadores, com o conhecimento sobre a capacidade e segurança desta plataforma – o adotassem para realizar um processo que envolveu mais de 20 mil pessoas.
Projeto Pedagógico Institucional (2022 - 2036): metodologia participativa para elaboração do Projeto Pedagógico Institucional da Universidade Federal de Pelotas
Authors:   Universidade Federal de Pelotas
Published: September 2023

O atual Projeto Pedagógico Institucional (PPI) da UFPel data de 1991, com atualização em 2003. A partir dele são definidos os princípios orientadores, a missão e a visão da universidade, que refletem as concepções da comunidade acadêmica. O documento vigente traz itens que, de certa forma não remetem mais ao perfil de formação da UFPel, tais como, por exemplo, a oferta de cursos seqüenciais e cursos profissionalizantes de ensino médio, entre outros. Por outro lado, existem demandas que não estão contempladas, ou mesmo, ainda não pensadas no texto, como o perfil dos técnicos administrativos em educação (TAEs). A necessidade de atualização do PPI justifica-se tendo em vista as mudanças ocorridas na sociedade, desde a última atualização (2003), bem como as transformações evidenciadas na UFPel, tanto em termos de ampliação do número de cursos de graduação e de pós-graduação, matrículas, servidores (docentes e TAEs), ofertas de eventos de extensão, projetos de pesquisa cadastrados, mas, sobretudo, em relação às políticas institucionais de democratização do acesso, que tornou a universidade mais diversa e plural; quanto em termos de atuação e impactos das ações universitárias no cenário local/regional, nacional e internacional.
Cultura para todos: instrumento de avaliação de acessibilidade para ambientes culturais
Authors: Nobre Salasar Desirée , de Castro Barros Fonseca Tatiana
Published: September 2023

Trata-se de um instrumento voltado para o diagnóstico dos espaços a partir de um processo de identificação sistematizado e, sobretudo, atento aos protocolos de avaliação já em vigor, à legislação e recomendações atuais, aos documentos constituídos em diferentes fóruns de discussão, às normativas técnicas e a conceitos fundamentais da área de conhecimento das autoras. Há outro elemento de destaque, que ressalto com grifos especiais: a experiência das autoras como terapeutas ocupacionais que atuaram em museu inclusivos e que vivenciaram o trabalho de equipes interdisciplinares. A magnitude do objetivo, qual seja o de fazer a cultura acessível a todos, não admite um ou poucos pontos de vista, uma ou escassas abordagens, exíguas verdades, conceitos fechados e mentes disciplinadas em conteúdos específicos. Demanda pensamento ativo, concepções abertas e para tanto, muito diálogo sobre e com as diferenças.
omida, ética e reciprocidade em tempos de pandemia: diálogos entre Brasil, Espanha e Itália
Authors: Sacco dos Anjos Flávio , Velleda Caldas Nádia
Published: September 2023

No apagar das luzes do ano 2019, a Organização Mundial de Saúde (OMS) foi advertida a respeito da eclosão de diversos casos de pneumonia na República Popular da China, mais precisamente na cidade de Wuhan, Província de Hubei. Surgia, assim, uma nova cepa de coronavírus nunca antes identificada na espécie humana. O aumento rápido no número de casos dessa doença respiratória e as primeiras centenas de óbitos converteram-se em tema de crescente preocupação por parte das autoridades sanitárias. Em 11 de fevereiro de 2020, a enfermidade passou a ser referida como covid-19, momento em que se converteu numa pandemia, alcançando os cinco continentes do planeta. Longe de ser definitivamente debelada, a pandemia da covid-19 representa hoje um divisor de águas na história recente da humanidade, cujos efeitos alcançam os mais recônditos âmbitos da vida humana, assim como das diversas instituições e relações estabelecidas entre os indivíduos. Os impactos estão ainda sendo avaliados, mas são claros os sinais de recrudescimento da injustiça e da desigualdade social, bem como de uma abissal concentração de renda e forte precarização das relações de trabalho.
Tonic Activation of NR2D-Containing NMDARs Exacerbates Dopaminergic Neuronal Loss in MPTP-Injected Parkinsonian Mice
Authors: Sharma Ramesh , Neupane Chiranjivi , Pham Thuy Linh , Lee Miae , Lee Sanghoon , Lee So Yeong , Nam Min-Ho , Kim Cuk-Seong , Park Jin Bong
Published: September 2023

NR2D subunit-containing NMDA receptors (NMDARs) gradually disappear during brain maturation but can be recruited by pathophysiological stimuli in the adult brain. Here, we report that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication recruited NR2D subunit-containing NMDARs that generated an Mg2+-resistant tonic NMDA current (INMDA) in dopaminergic (DA) neurons in the midbrain of mature male mice. MPTP selectively generated an Mg2+-resistant tonic INMDAin DA neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA). Consistently, MPTP increased NR2D but not NR2B expression in the midbrain regions. Pharmacological or genetic NR2D interventions abolished the generation of Mg2+-resistant tonic INMDAin SNpc DA neurons, and thus attenuated subsequent DA neuronal loss and gait deficits in MPTP-treated mice. These results show that extrasynaptic NR2D recruitment generates Mg2+-resistant tonic INMDAand exacerbates DA neuronal loss, thus contributing to MPTP-induced Parkinsonism. The state-dependent NR2D recruitment could be a novel therapeutic target for mitigating cell type-specific neuronal death in neurodegenerative diseases.

SIGNIFICANCE STATEMENTNR2D subunit-containing NMDA receptors (NMDARs) are widely expressed in the brain during late embryonic and early postnatal development, and then downregulated during brain maturation and preserved at low levels in a few regions of the adult brain. Certain stimuli can recruit NR2D subunits to generate tonic persistent NMDAR currents in nondepolarized neurons in the mature brain. Our results show that MPTP intoxication recruits NR2D subunits in midbrain dopaminergic (DA) neurons, which leads to tonic NMDAR current-promoting dopaminergic neuronal death and consequent abnormal gait behavior in the MPTP mouse model of Parkinson's disease (PD). This is the first study to indicate that extrasynaptic NR2D recruitment could be a target for preventing neuronal death in neurodegenerative diseases.
Diferencias en Factores de Innovación en Profesores de Ciencias y Matemáticas en ESO
Authors: Monge Carlos , Gómez Patricia
Published: September 2023

La innovación se ha convertido en un elemento clave en los centros educativos de cara a mejorar el desempeño profesional docente y facilitar un proceso de enseñanza-aprendizaje de calidad para todos. Hay muchos aspectos que condicionan la innovación, entre los que destaca el ámbito o rama de conocimiento al que pertenece el profesorado. Conocer los factores que condicionan la innovación parece ser un punto necesario para introducir y desarrollar mejoras factibles en los centros educativos. Por ello, el objetivo principal de esta investigación fue analizar los factores de innovación del profesorado de Ciencias y Matemáticas de Educación Secundaria Obligatoria en función de algunas variables claves. Se desarrolló un estudio por encuesta donde participaron 1.440 docentes de todo el territorio español, a quienes se les aplicó el Cuestionario de Factores de Innovación Docente. Los principales resultados arrojaron diferencias significativas entre el profesorado de Ciencias y Matemáticas en función de las variables analizadas en tres de los factores de innovación docente: participación institucional, apertura psicopedagógica y planificación didáctica. En conclusión, el sexo, la edad y la experiencia del profesorado y la titularidad del centro educativo, el tamaño del instituto y su ámbito de actuación suponen elementos fundamentales que determinan la innovación docente
Inpatient Screening of Parental Adversity and Strengths
Authors: Shah Anita N. , Goodman Emily , Lawler Julianne , Bosse Dianna , Rubeiz Christine , Beck Andrew F. , Parsons Allison
Published: September 2023

BACKGROUND AND OBJECTIVES

Social adversities, including health-harming social risks and adverse childhood experiences, contribute to poor outcomes after hospital discharge. Screening for social adversities is increasingly pursued in outpatient settings. Identifying and addressing such adversities has been linked to improved child outcomes. Screening for social adversities and strengths in the inpatient setting may contribute to better transitions from hospital to home. Our goal was twofold: 1. to use qualitative methods to understand parent perspectives around screening tools for potential use in inpatient settings; and 2. to develop a family-friendly inpatient screening tool for social adversity.

METHODS

We used in-depth, cognitive qualitative interviews with parents to elicit their views on existing screening tools covering social adversities and strengths. We partnered with a local nonprofit to recruit parents who recently had a child hospitalized or visited the emergency department. There were 2 phases of the study. In the first phase, we used qualitative methods to develop a screening prototype. In the second phase, we obtained feedback on the prototype.

RESULTS

We interviewed 18 parents who identified 3 major themes around screening: 1. factors that promote parents to respond openly and honestly during screening; 2. feedback about screening tools and the prototype; and 3. screening should include resources.

CONCLUSIONS

Social adversity routinely affects children; hospitalization is an important time to screen families for adversity and potential coexisting strengths. Using qualitative parent feedback, we developed the family friendly Collaborate to Optimize Parent Experience screening tool.
Paratexte, ohne die es keine Literatur gäbe. Zur Rezeption des Werkes von Paul Celan und der Funktion von Paratexten in der totalitären Tschechoslowakei (1948–1989)
Authors: Pytlík Petr
Published: September 2023

The reception of literature written in German in Czechoslovakia after the Second World War was (and still is) in a hybrid position, oscillating between aversion to historical events that still resonate in Czech culture and society, and interest due to intensive cultural contacts and exchange projects between Germany and the Czech Republic. The reception of works by Paul Celan was all the more complicated because Jewish issues were by and large considered undesirable by the communist regime. The regime was officially only anti-Zionist, but de facto, as is well known, this meant anti-Semitic. In this article, attention is drawn to a neglected aspect of the surprising history of the reception of Celan’s poems in Czechoslovakia between 1945 and 1989 (with a brief excursion into the period 1990–2020) – namely, the “mediating function” of paratexts in the totalitarian regime. The first part briefly presents a definition of the term “paratext” and outlines the function of this type of text (taking into account the specific situation in which literature found itself in socialist Czechoslovakia). The following part illustrates the “mediating function” of paratexts in the Czechoslovak and the Czech editions of Celan’s poems.
The relationship between parenting styles and adolescent problematic Internet use: A three-level meta-analysis
Authors: Niu Xiang , Li Jie-yang , King Daniel L. , Rost Detlef H. , Wang Hai-Zhen , Wang Jin-Liang
Published: September 2023

Background and aims

Problematic Internet use (PIU) has become a global public health problem. It has been suggested that parenting style is associated with adolescent PIU. However, the evidence in favor of this view is mixed. Based on the PRISMA method, the present study employed three-level meta-analysis approach to investigate the relationship between these two variables and further explore potential moderators.

Methods

After a systematic search for published articles, 35 studies were included, reporting 171 effect sizes (N = 40,587).

Results

The results showed that positive parenting styles were significantly negatively related to PIU. This association was moderated by gender, age, publication year, and measurements of PIU, but was not by culture and measurements of parenting styles. Negative parenting styles were significantly positively related to PIU, which was moderated by publication year, culture, and sub-types of negative parenting, but not by gender, age, and measurements of both parenting styles and PIU. In addition, the correlation of PIU with negative parenting styles was stronger than that with positive parenting styles.

Discussion and Conclusions

The present results demonstrated that parenting styles, especially punitive parenting styles, should be attached to more important when treating adolescent PIU.
Archaeobotanical Materials from the Golden Horde Settlements of the Saratov Volga Region
Authors:   Kazan (Volga region) Federal University, Nedashkovsky Leonard , Kochanova Maria ,   Institute of Archaeology of the Russian Academy of Sciences, Aleshinskaya Anna ,   Institute of Archaeology of the Russian Academy of Sciences, Spiridonova Elena ,   Institute of Archaeology of the Russian Academy of Sciences
Published: September 2023

Introduction. The article considers archaeobotanical data obtained as a result of the analysis of plant macro- and microremains from the settlements of the Golden Horde epoch in the central part of the Saratov Volga region. Methods and materials. The results of the analyses of flotation samples allow us to obtain data on the plant food of the settled population. The interpretation of spore-pollen analyses allows us to trace the process of growth of the territory of monuments, the nature of the lands surrounding them, and the natural conditions and occupations of the population. Analysis. Finds of ear fragments were noted – traces of the threshing of cereals by the population of the studied monuments. On the Bagaevka settlement, six samples from trench I of 2012 were studied by the palynological method, and according to the results of the analysis, three spore-pollen complexes were allocated. Results. The rural economy of the settled population of the Saratov Volga region in the Golden Horde time was quite well developed; millet, wheat, rye, barley, oats, peas, and lentils were mainly cultivated here. Palynological data propose the agriculture at the Bagaevka settlement in all stages of its existence. The available materials indicate that the population of these monuments engaged in farming and had the opportunity to cultivate the nearby fertile black soils. Authors contribution. L.F. Nedashkovsky summarized the available data on archaeobotanical macroremains. M.D. Kochanova carried out chemical processing of samples for palynological analysis, computer processing of data and plotting, and summarized the available data on microremains. A.S. Aleshinskaya conducted spore-pollen analyses on samples. E.A. Spiridonova interpreted the results of palynological analyses.
Assessment of the economic security system of «TransLogistik» LLC
Authors: Ovakimyan Levon
Published: September 2023

In this article, the author considers the system of economic security of TransLogistics LLC. The article is aimed at analyzing and evaluating the effectiveness of the SES of the specified enterprise. The author notes that enterprises operating in the transport and logistics industry are characterized by the presence of a large set of business processes, which, in turn, increases the number of vulnerabilities and increases the possibility of fraud. The article presents a list of departments responsible for fraud detection within the enterprise in question. Special attention is paid to the issue of information security. According to the author, this is due to the fact that disclosure of information can lead to significant financial and reputational costs. It is noted that the activity of the economic security service is based on the charter of the company and the policy of information security. The author also focuses on the fact that in building a system of economic security, compliance control plays a particularly important role, which establishes the compliance of the activities of an economic entity with acts of the legislative framework. According to the author, the frequency and forms of fraudulent activities largely depend on the organizational structure of the enterprise and ongoing business processes. An analysis of these aspects will make it possible to determine at what stage and by whom a particular offense is committed, as well as to timely implement measures to eliminate them and further prevent them at the identified stages. The author argues that the fraud matrix is a practically useful and effective tool in this case. The article details the meaning of this matrix and the principles of its compilation. The most common form of corporate fraud, according to the author, is partnership actions that do not comply with contractual obligations or concealment by them of true information about their financial situation. The article provides a relevant example and the consequences of this form of fraud. In the final part of the article, the author formulates conclusions regarding the effectiveness of the instrumental apparatus used to combat corporate fraud.
Efficiency of financial management of energy companies as a component of ensuring the financial stability of the industry
Authors: Antonov Ivan
Published: September 2023

The management of financial resources of energy companies is one of the key aspects that ensure the efficiency of such companies, as a result of which the energy industry in the Russian Federation is more sustainable. The author analyzes the specifics of the energy industry and the history of the formation of the world energy market. The process of implementing a financial management system is described, the criteria for the effectiveness of this system are studied in more detail. According to the author, the main criterion for the effectiveness of energy finance management is the availability of a certain amount of funds in the bank accounts of industry enterprises, as well as a positive amount of free cash flows. In addition, the author describes the main stages of energy finance management, as well as the main task of energy industry managers, which is to develop a rational system of benchmarks for the main divisions of the industry, which is real and achievable. Based on the conducted research, the author concludes that the formation of a correct and optimal system of benchmarks that can be applied at different levels of management of the system of financial assets of energy companies. Financial stability is considered as the most important control parameter, which allows not only to develop individual companies operating in the energy industry, but also to increase the stability of the entire energy segment as a whole, which is quite important taking into account the specifics and peculiarities of the functioning of the domestic economy. In the context of sanctions pressure and the current situation around the energy sector of the Russian economy, effective financial management of energy companies is an integral part of ensuring sustainability and development.
The Role of T Cells in Alzheimer's Disease Pathogenesis
Authors: Zhao Jin , Wang Xiaofang , He Yusheng , Xu Pingyi , Lai Laijun , Chung Younggie , Pan Xinghua
Published: September 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with memory decline and cognitive impairment, which is related to hallmark protein aggregates, amyloid-β (Аβ) plaques and neurofibrillary tangles; the latter are accumulated with hyperphosphorylated Tau protein. Immune cells play an important role in AD pathogenesis. Although the role of T cells in AD remains controversial, studies have shown that T cell deficiency is associated with increased AD pathology. In contrast, transplantation of T cells reduces AD pathology. T cells can help B cells generate anti-Аβ antibody to neutralize the toxin of Аβ and hyperphosphorylated Tau. T cells also activate macrophages to phagocytose misfolded proteins including Аβ and Tau. Recent data have also shown that AD animals have a damaged thymic microenvironment, especially thymic epithelial cells (TECs), resulting in decreased T cell numbers, which contribute to AD pathology. Therefore, regulation of T cell regeneration, for example by rejuvenating the thymic microenvironment, has the potential to be used in the treatment of AD.
PHYSICS-INFORMED POINTNET: ON HOW MANY IRREGULAR GEOMETRIES CAN IT SOLVE AN INVERSE PROBLEM SIMULTANEOUSLY? APPLICATION TO LINEAR ELASTICITY
Authors: Kashefi Ali , Guibas Leonidas J. , Mukerji Tapan
Published: September 2023

Regular physics-informed neural networks (PINNs) predict the solution of partial differential equations using sparse labeled data but only over a single domain. On the other hand, fully supervised learning models are first trained usually over a few thousand domains with known solutions (i.e., labeled data) and then predict the solution over a few hundred unseen domains. Physics-informed PointNet (PIPN) is primarily designed to fill this gap between PINNs (as weakly supervised learning models) and fully supervised learning models. In this article, we demonstrate for the first time that PIPN predicts the solution of desired partial differential equations over a few hundred domains
simultaneously, while it only uses sparse labeled data. This framework benefits fast geometric designs in the industry when only sparse labeled data are available. Particularly, we show that PIPN predicts the solution of a plane stress problem over more than 500 domains with different geometries, simultaneously. Moreover, we pioneer implementing the concept of remarkable batch size (i.e., the
number of geometries fed into PIPN at each sub-epoch) into PIPN. We systematically try batch sizes of 7, 14, 19, 38, 76, and 133. Additionally, we systematically investigate for the first time the effect of the PIPN size, symmetric function in the PIPN architecture, and static and dynamic weights for the component of the sparse labeled data in the PIPN loss function.
The social structure of signing communities and lexical variation: A cross-linguistic comparison of three unrelated sign languages
Authors: Lutzenberger Hannah , Mudd Katie , Stamp Rose , Schembri Adam Charles
Published: September 2023

Claims have been made about the relationship between the degree of lexical variation and the social structure of a sign language community (e.g., population size), but to date there exist no large-scale cross-linguistic comparisons to address these claims. In this study, we present a cross-linguistic analysis of lexical variation in three signing communities: Kata Kolok, Israeli Sign Language (ISL) and British Sign Language (BSL). Contrary to the prediction that BSL would have the lowest degree of lexical variation because it has the largest population size, we found that BSL has the highest degree of lexical variation across the entire community (i.e., at the global level). We find, however, that BSL has the lowest degree of lexical variation at the local level, i.e., within clusters of participants who group most similarly lexically. Kata Kolok and ISL, on the other hand, exhibit less of a distinction between variation at the global and local levels, suggesting that lexical variation does not pattern as strongly within subsets of these two communities as does BSL. The results of this study require us to reassess claims made about lexical variation and community structure; we need to move towards an approach of studying (lexical) variation which treats communities equally on a theoretical level and which respects the unique social-demographic profile of each community when designing the analysis by using a community-centered approach.
Stowers Institute for Medical Research Rodent Facility Environmental Summary v1
Authors: Dukes Debra
Published: September 2023

Mice (Mus Musculus) are the most common research organisms used in biomedical research. We have housed and maintained a variety of strains at the Stowers Institute for Medical Research since 2000.Our environment and housing parameters provide a standardized guideline for our staff to follow.This information assures the protection of our research using the rodent model, with proper use of housing, nutrition, maintenance, and environmental enrichments for the healthiest rodent specimensfor our research. The provided guideline is currently being used at the Stowers Institute in 2023.
Handling and Sampling Birds - ISL Peru v1
Authors: Luis Mendoza-Silva Jorge
Published: September 2023

Program Timing: Sample collection occurs annually during the rainforest dry season (June - August). Sample transport and analyses occur between September and April. Program Overview: Mist nets are set up at multiple locations encompassing major habitat types surrounding the field station (terra firme, flood plain, swamp, bamboo, successional forest, primary forest, edge forest, etc). Mist netting occurs over 3 consecutive days at each location throughout the sample collection period. Team Composition This protocol is intended to be carried out by a team of no less than 3 individuals, including at least 2 trained personnel. Roles include (1) designated handler (2) sampling assistant (3) data recorder. Capture Overview: Mist nets are opened between 0500 and 1000 hours, and captures occur spontaneously throughout (~ 5 - 25 animals/event) -> animals are extracted from the net (1-2 minutes) -> transferred into a light and breathable cloth bag and held in order-of-capture in a nearby tent until processing (0 - 30 minutes) -> one-by-one animals are processed for morphometric measurements, photographs, nonlethal tissue collection, and placement of leg bands (~10 minutes) -> animals are immediately released at the site of capture, but away from mist nets.
A computational pipeline to quantify perinuclear lysosomes in fibroblasts using CellProfiler v1
Authors: Jaimon Ebsy
Published: September 2023

Here we present a CellProfiler software pipeline to quantify the distribution of lysosomes in MEF cells. The lysosomes were stained using anti-LAMP1 antibody, and nuclei were labeled using DAPI. The images were acquired using a Zeiss laser scanning confocal microscope and were maximum intensity projected in FIJI.
Submitting Genomes v1
Authors: not provided emma.pearce
Published: September 2023

Steps to submit a genome to NCBI through Bankit
Plant Monitoring Using a Web-View-Based Android Application as a Realization of the Implementation of the Smart Agriculture Concept
Authors: Supriyanto Supriyanto , Rohmat Rohmat
Published: September 2023

The concept of Smart Farming has been adopted by utilizing microcontrollers, sensor devices, and actuators to regulate plant conditions. However, the communication methods with farmers, such as text messaging applications, are considered ineffective due to their limited features, and farmers cannot control monitoring devices. To address this issue, we developed a web-view-based application named Prospherine Smart Farming using PHP, Java, and MongoDB. The Software Development Life Cycle (SDLC) methodology was employed to ensure the proper functioning of the application. This application has comprehensive features that enable farmers to control monitoring devices, even remotely, and provide continuous information about farming conditions. Testing was conducted to ensure that all features functioned properly, and feedback was obtained from farmers. The research results indicate that using the Prospherine Smart Farming Application positively impacts farming activities. With this application, farmers can monitor their farming conditions in real-time and take necessary actions to enhance crop yields. The Prospherine Smart Farming Application can potentially improve agricultural efficiency and assist farmers in tackling challenges in the digital era.
Doctors Fact-Check, Journalists Get Fact-Checked: Comparing Public Trust in Journalism and Healthcare
Authors: Moon Young Eun , Roschke Kristy , Nelson Jacob L. , Lewis Seth C.
Published: September 2023

Public trust in journalism has fallen disconcertingly low. This study sets out to understand the news industry’s credibility crisis by comparing public perceptions of journalism with public perceptions of another institution facing similar trust challenges: healthcare. Drawing on in-depth interviews with 31 US adults, we find that although both healthcare and journalism face public distrust, members of the public generally tend to feel more trusting of individual doctors than they do of individual journalists. This is because people (a) perceive doctors to be experts in their field and (b) engage more frequently with doctors than they do with journalists. Consequently, our interviewees described treating their doctors as “fact-checkers” when it comes to health information they find online, demonstrating trust in their physicians despite their lack of trust in healthcare more broadly. Meanwhile, the opposite unfolds in journalism: Instead of using legitimate news sources to fact-check potential misinformation, people feel compelled to “fact-check” legitimate news by seeking alternative sources of corroboration. We conclude that, to improve their credibility among the public, journalists must strike the right balance between persuading the public to perceive them as experts while also pursuing opportunities to engage with the public as peers.
“Small Tragedies of Individuals’ Lives”: London’s Migrant Division of Labour and Migrant Language Educational Settings
Authors: Zschomler Silke
Published: September 2023

This article highlights the lived experience of migrants who have come to London to set up a new life and are learning English to facilitate this process. Drawing on my ethnographic research with a heterogenous group of adult migrants within and beyond the institutional boundaries of a migrant language educational setting in London, I tease out the often painful experiences and effects of deskilling my participants are confronted with as they are trying to make their lives in the city. Language proficiency is commonly seen as a key factor that accounts for migrants’ disparities regarding their labour market participation and linguistic competence often acts as a crucial gatekeeping mechanism to social inclusion, which is additionally impeded by wider structural constraints. In this context, my research highlights the ways in which my interlocutors find themselves caught up in entrenched forms of intersecting inequalities, unequal power relations, and the dynamics and conditions of London’s migrant division of labour. I shed light on how my participants deal with and navigate these complex processes whilst questing for the “right” linguistic competence to somehow propel their lives forward despite being aware that this might not necessarily come to fruition. I draw particular attention to the emotional cost of deskilling and being bumped down and show how this not only leaves an imprint on migrants themselves but also on those who are teaching them in order to increase migrants’ employability and social mobility.
The Effect of Digital Transformation on Corruption: A Global Analysis
Authors:   Indiana University South Bend, Merhi Mohammad I.
Published: September 2023

Background: This study investigates the effect of digital transformation on corruption at country level. Very few studies have empirically investigated this phenomenon. The model presented lays the relationships between socio-technical and socio-political factors and their impact on technological factors, which in turn, influence corruption. Methods: Secondary data from 139 countries collected by credible international organizations are used for the empirical analyses. The sample of 139 countries, used in this study, makes the results more robust and generalizable than those published in previous studies. PLS-SEM and multi-group analysis were used to test the hypotheses presented in the research model. Results: The results of the analysis show that digital transformation can significantly lower the corruption. The empirical analysis also demonstrates that socio-technical and socio-political factors are important in supporting the technological factors in reducing corruption. Multi-group analysis based on the GNI categorization of the World Bank revealed fine results for nations of different economic level. The significance of the relationships varies based on the development level of the country. Conclusions: This study contributes to the growing empirical base of literature on digital transformation and corruption by empirically assessing new relationships that have not been explored in the extant literature using a relatively larger sample size. The results suggest that technology plays a critical role in reducing the corruption in any country. Factors such as infrastructure, e-participation, education/human capital, laws relating to ICT, and Importance of ICT to government are found to be vital for fighting corruption.
Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov region
Authors: Berezin P. G. , Milovanov V. V. , Ivannikov A. A. , Kuleshkov V. A. , Nyushko K. M.
Published: September 2023

Treatment of patients with metastatic castration-resistant prostate cancer in clinical practice is a vital necessity and a challenging task since the causes of castration resistance are not fully understood. Adherence to treatment regimens in accordance with the National Clinical Guidelines allows to achieve an increase in both overall survival and progression-free survival, as well as to reduce the mortality rate in this category of patients. Administration of 1st-line treatment regimens stabilizes the disease in the majority of pancreatic cancer patients; in some cases, the disease becomes aggressive, distant metastases appear, most oﬅen in bones, lymph nodes, and internal organs, as demonstrated by three clinical observations presented in this article. The administration of enzalutamide (in 2 cases) and abiraterone acetate (in 1 case) at the stage of resistance to castration therapy allowed to obtain a complete “response” from visceral lesions, stabilise bone metastatic foci and increase the life expectancy of patients.
«Forgotten» encrusted ureteral stents
Authors: Frantsev R. S. , Kuchuk A. V.
Published: September 2023

The article presents a rare clinical observation of patient S., 50 years old, a long-term suﬀerer of urolithiasis, who was admitted to the urological department of the hospital with a clinical picture of renal colic on the leﬅ side, exacerbation of chronic pyelonephritis. From the anamnesis: in 2021, internal stenting of both ureters was performed as indicated. Despite detailed recommendations at discharge, the patient did not consult doctors or take any medications until 2023. The examination revealed that the cause of exacerbation of chronic pyelonephritis and impaired urine outflow were encrusted (“forgotten”) stents in both ureters, in the leﬅ of which there was a concrement obstructing urine outflow. Ureteroscopy on the right side, stent fragments extraction; ureteroscopy on the leﬅ side, contact lithotripsy, removal of the encrusted ureteral stent; urinary passage and independent urination were restored. Despite technical diﬃculties during the surgical intervention, the postoperative period proceeded without complications.
Clinical observation of genetically confirmed Kabuki syndrome type 1, with an undetermined type of inheritance, in a 7-year-old child
Authors: Gorkina Oksana K. , Pavlov Pavel V. , Zakharova Maria L. , Nikitina Nadezhda V.
Published: September 2023

Kabuki syndrome is a rare hereditary disease that has a specific clinical picture: facial features, growth retardation, muscular hypotonia, skeletal abnormalities, dermatoglyphic abnormalities, mild to moderate mental retardation, and postnatal growth deficiency. Kabuki syndrome (Kabuki mask syndrome / Kabuki makeup syndrome) got its name for the specific features of the appearance of patients who have a facial expression similar to a special makeup that highlights the eyes and eyebrows of the characters of the Japanese Kabuki theater. The main reasons for the development of Kabuki syndrome in 75% are mutations in the KMT2D gene (KS type 1) and in 5% are mutations in the KDM6A gene (Kabuki syndrome type 2), the etiology of about 20% of cases remains unknown. Most mutations in type 1 Kabuki syndrome are formed de novo, and cases of autosomal dominant inheritance have also been described. Type 2 Kabuki syndrome has sex-linked (X-linked) inheritance. Because Kabuki syndrome is a low-prevalence, multisystem disease, patients require a variety of diagnostic and screening tests with multidisciplinary evaluation of outcomes at different stages of their lives. Early diagnosis of the disease is crucial for timely treatment and rehabilitation measures and improving the prognosis and quality of life of the child. The interest of the presented clinical observation of Kabuki syndrome lies in the importance of early recognition of clinical manifestations, timely surgical treatment, hearing rehabilitation and improving the prognosis of the patients life. The article describes a clinical observation, genetically confirmed type 1 Kabuki syndrome, in a child born in 2015 (type of inheritance not established). The interest of the presented clinical observation of Kabuki syndrome, manifested by characteristic facial features, skeletal anomalies, postnatal growth retardation, dermatoglyphic anomalies, intellectual retardation, lies in the need for a multidisciplinary approach to the diagnosis and treatment of the patient.
Prediction of ADHD in Adolescents Utilizing fMRI-Based Individual Cortical Thickness Measurements
Authors:   , Dengler Julia , Ayaz Hasan , Medaglia John D
Published: September 2023

Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric disorder primarily affecting youth defined by symptoms of inattention and impulsivity. Current diagnosis tools consist of questionaries and tasks which are subject to biases. A quantitative and objective measurement for diagnosis does not exist. The use of fMRI-derived metrics, such as cortical thickness measurements, has gained popularity in diagnosing disease. Since cortical thickness differences exist in adolescents with ADHD, prediction algorithms can be written using this metric to diagnose ADHD. To determine regions most likely to predict ADHD, cortical thickness measurements were extracted in functional regions associated with symptoms of inattention and impulsivity, as well as for the whole brain. Four different types of classification models were created and tested across the three different functional conditions: inattention, impulsivity, and whole brain. 238 ADHD and 244 healthy adolescent participants from the ADHD 200 publicly available dataset were used to test and train the models. Across all models, the average accuracy measure was 63.83% (+/- 2.2%). There were no differences in accuracy values between the different functional networks associated with symptoms and the whole brain analysis. Support vector classification (SVC) predicted ADHD the most accurately across the different functional network conditions. Specificity was found to be slightly better than sensitivity across SVC models. Overall, cortical thickness provides a new avenue of possible prediction in diagnosing ADHD. Further work evaluating hemispheric cortical thickness differences and extracting the functional networks most responsible for accurate prediction needs to be completed to better understand how the models work.
Power to Change One's Robes
Authors:   , Hatchett Dennis Lee , Nag Rajiv , D'Innocenzo Lauren
Published: September 2023

This is a research study on how major polarizing events affect, highlight, and inform the professional relationships, personal effectiveness and organizational identification of Black professionals. The specificity of this study was intended to allow the researcher to excavate learnings that could be reapplied for the broader benefit of all professionals. Moreover, this research seeks to understand if these types of events create a vicious or virtuous cycle for Black professionals and the corporate ecosystems within which they exist. This study is a critical examination of the intersection of professional identity, meaning making, and voice work amid major and polarizing societal events. This research looks beyond the routine, albeit tragic, stories that dominate America's news cycle, and to the rare events that become catalysts for corporate, political, social and personal change. Identity, voice and meaning making were specifically chosen as the three areas of study given their centrality to relationships, effectiveness and identification; and their connection to the primary causes of one recent event of note, the George Floyd murder, which became the context for how many Black Americans saw themselves. All Americans, not just Black Americans, were attempting to make meaning of their first pandemic. Lastly, the charged political environment left many attempting to find their voice or wondering if they were going to be silenced by others with differing views. While there is much to be studied on the individual components of identity, voice and meaning making, there is very little research that explores both the interactive and iterative nature of all three. This study develops a foundation for such future work. Finally, this research seeks to determine if any of the key findings can be used to improve or enhance existing DE&I training and development constructs. This pragmatic approach is an attempt to address an ever-changing corporate landscape.