bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of long-haul COVID-19 toward domains of the health-related quality of life among recovered hospitalized patients
Authors: Trihandini Indang , Muhtar Manendra , Karunia Sakti Dea Allan , Erlianti Chintya Putri
Published: August 2023

Background

People with long-haul COVID-19 could experience various health problems, from mild to severe. This research aimed to identify the effect of long-haul COVID-19, specifically on the Quality-of-Life domains experienced by COVID-19 patients who have been discharged.

Methods

Data collection was done online, using data from DKI Jakarta hospitalized patients confirmed with and recovered from SARS-CoV-2 infections. We selected patients who have a minimum of 28 days after being hospitalized for COVID-19 positive. The Logistic regression technique was used to analyze the data. The questionnaire used in this research contained questions regarding long-haul COVID-19 symptoms and domains of Quality of Life, which WHOQOL-BREF measured. Before collecting data, we tested the questionnaire with 30 recovered patients hospitalized outside DKI Jakarta.

Results

172 recovered inpatients who filled out the questionnaire correctly and were aged 18 years and above were randomly selected. Almost one-third (30.2%) of the recovered inpatients had long-haul COVID-19, with 23.8% experiencing one long-haul symptom and 6.4% experiencing more than one symptom. This research also showed that the long-haul effects of COVID-19 affected almost all domains of Quality of Life except the environmental one. Age, gender, and marital status were covariates for the association between long-haul COVID-19 and The Quality of Life.

Conclusion

Continuing health services after the patient is discharged from the hospital is an important program for COVID-19 survivors because it can prevent a decline in the Quality of Life among patients due to the long-haul COVID-19.
Does the first generic exclusivity system provide an economic incentive for early generic entrance under the patent linkage system?
Authors: Son Kyung-Bok
Published: August 2023

Introduction

A period of exclusivity for the first generics, as part of the patent linkage system, was established in South Korea to provide an economic incentive for early generic entry. This study describes the dynamics of generic penetration and assesses the first mover market share advantages under the patent linkage system.

Methods

Pairs of originators and their corresponding generics granted the first generic exclusivity from 2015 to 2020 were identified. We categorized generics into first movers and latecomers, described the penetration curves of generics, and estimated the saturated market share of generics, first movers, and latecomers. Volume-based monthly prescriptions were used to describe the generics’ penetration curves. A logistic growth model was adopted to estimate the saturated market shares of generics.

Results

We identified 28 pairs of originators and generics, presented penetration curves, and estimated generics market shares. The saturated market share of generics was 30%, and the time to saturation was approximately 33 months. The shapes of penetration varied by nationality, route, and number of generics. The existence of latecomers was associated with the decreased penetration speed over time and decreased market share of generics. However, the first mover market share advantages or latecomers’ disadvantages were consistently observed.

Conclusion

The generic uptake in South Korea is delayed, limited, and context-dependent. However, first generics’ market share advantage suggests that a period of exclusivity, as part of the patent linkage system, could provide an economic incentive for early generic entrance.
Barriers and strategies for recruiting participants who identify as racial minorities in musculoskeletal health research: a scoping review
Authors: Le Denise , Almaw Rachel D. , Rinaldi Daniel , Ivanochko Natasha K. , Harris Sheereen , Benjamin Ashley , Maly Monica R.
Published: August 2023

Objective

Visible minorities are disproportionately affected by musculoskeletal disorders (MSD) and other diseases; yet are largely underrepresented in health research. The purpose of this scoping review was to identify barriers and strategies associated with increasing recruitment of visible minorities in MSD research.

Methods

Electronic databases (MEDLINE, EMBASE, CINAHL, and PsycInfo) were searched. Search strategies used terms related to the concepts of ‘race/ethnicity’, ‘participation’, ‘research’ and ‘musculoskeletal’. All research designs were included. Two reviewers independently screened titles and abstracts, completed full-text reviews, and extracted data. Papers that did not focus on musculoskeletal research, include racial minorities, or focus on participation in research were excluded. Study characteristics (study location, design and methods; sample characteristics (size, age, sex and race); MSD of interest) as well as barriers and strategies to increasing participation of visible minorities in MSD research were extracted from each article and summarized in a table format.

Results

Of the 4,282 articles identified, 28 met inclusion criteria and were included. The majority were conducted in the United States (27 articles). Of the included studies, the groups of visible minorities represented were Black (25 articles), Hispanic (14 articles), Asian (6 articles), Indigenous (3 articles), Middle Eastern (1 article), and Multiracial (1 article). The most commonly cited barriers to research participation were mistrust, logistical barriers (e.g., transportation, inaccessible study location, financial constraints), and lack of awareness or understanding of research. Strategies for increasing diversity were ensuring benefit of participants, recruiting through sites serving the community of interest, and addressing logistical barriers.

Conclusion

Understanding the importance of diversity in MSD research, collaborating with communities of visible minorities, and addressing logistical barriers may be effective in reducing barriers to the participation of visible minorities in health research. This review presents strategies to aid researchers in increasing inclusion in MSD-related research.
Perceptions of antimicrobial stewardship: identifying drivers and barriers across various professions in Canada utilizing a one health approach
Authors: McCubbin Kayley D. , de Jong Ellen , Smid Anne-Marieke C. , Ida Jennifer A. , Bodaneze Julia , Anholt R. Michele , Larose Samantha , Otto Simon J. G. , Barkema Herman W.
Published: August 2023

Introduction

As antimicrobial resistance (AMR) represents a substantial threat to the efficacy of available antimicrobial options, it is important to understand how to implement effective and practical mitigation efforts, including antimicrobial stewardship (AMS), across human, animal, and environmental sectors.

Methods

A mixed-methods questionnaire was distributed virtually to attendees of the virtual One Health Antimicrobial Stewardship Conference (March 10–12, 2021) and their professional networks. Respondents (n = 81) were largely from the veterinary (75%) or human (19%) health sectors. Qualitative data were analyzed in NVivo using template analysis whereas quantitative data were analyzed in STATA using Kruskall-Wallis tests. The questionnaire asked respondents about their perceptions of AMS, as well as the perceived barriers and drivers of AMS efforts.

Results

Perceptions of what AMS meant to the respondents personally and their profession as a whole were grouped into 3 main themes: 1) AMS strategies or considerations in antimicrobial prescribing and use; 2) responsibility to maintain health and preserve antimicrobial effectiveness; and 3) reducing antimicrobial use (AMU) as a goal of AMS efforts. Identified AMS barriers had 3 main themes: 1) lack of various prescribing and AMU support mechanisms; 2) shift in prescriber attitudes to drive change; and 3) stronger economic considerations to support shifting prescribing practices. Drivers of AMS had the following themes: 1) leadership to guide change; 2) education to support optimizing AMU; and 3) research to identify best practices and opportunities for action. Across all questions, 2 cross-cutting themes emerged: 1) a One Health understanding of AMS; and 2) blame placed on others for a lack of AMS success.

Conclusion

Overall, sector-specific, but particularly cross-sectoral AMS drivers and barriers were identified, highlighting the importance of a One Health approach in AMR research and mitigation.
Experimental Investigation on Morphological Characteristics and Propulsion Performance of Typical Metals Ablated with Multipulse Nanosecond Laser
Authors: Liu Hao , Ye Jifei , Li Mingyu , Gao Heyan
Published: August 2023

For laser ablation micropropulsion technology with metal as the target to increase the total impulse, the effective utilization and supply of a working medium is a crucial aspect. In this research, the ablation characteristics and propulsion performance of the typical metal targets, copper and aluminum, ablated via nanosecond laser ablation are analyzed. Due to the low melting point of aluminum, the protrusion characteristics in the remelted area are more prominent. Its surface morphology has characteristics for height extremum and roughness that are higher than those of copper. Affected by the anisotropy of the rough surface, the absorbed energy decreases with increasing roughness. The impulse coupling coefficient of the metal decreases and stabilizes at about 6 μN·W−1. The specific pulse of aluminum obtains a minimum value of 603.6 s at 6000 pulses and improves with increasing pulses. The propulsion parameters of copper alters slightly under various working conditions, with a maximum specific impulse of 685 s.
Effect of Physical Activity on Health-Related Quality of Life of Older Adults Using Newly Developed Health-Related Quality of Life Tool for the Korean Population
Authors: Seo Jungwoon , An Sangyong , Kim Daehee
Published: August 2023

This study aimed to investigate the effect of physical activity on health-related quality of life. Data from the 2019 Korean National Health and Nutrition Examination Survey were used. The participants were 1495 (56.7% women) older individuals older than 65 years of age. A one-way analysis of variance (ANOVA) and multiple regression analysis were performed to determine the effect of walking and strength exercise on the health-related quality of life using the Korean version of the health-related quality of life questionnaire called the Korean Health-Related Quality of Life Instrument with 8 Items (HINT-8). The one-way ANOVA revealed that the health-related quality of life (according to the HINT-8) differed depending on increases in walking and strength exercise. Furthermore, walking and strength exercise positively influenced the health-related quality of life according to the HINT-8. Therefore, this study showed that walking and strength exercise were associated with the health-related quality of life among older Korean individuals. This study will be helpful for future studies on the health-related quality of life of older individuals.
Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells
Authors: Yang Feifei , Wen Han , Ma Siqi , Chang Qi , Pan Ruile , Liu Xinmin , Liao Yonghong
Published: August 2023

Myelin repair, which is known as remyelination, is critical to the treatment of neurodegenerative diseases, and myelination depends on not only the differentiation of oligodendrocyte precursor cells toward oligodendrocytes but also the renewal of oligodendrocyte precursor cells under pathological conditions. However, simultaneously promoting the differentiation and proliferation of oligodendrocyte precursor cells in lesions remains an unmet challenge and might affect demyelinating diseases. Kidney-tonifying herbs of traditional Chinese medicine (TCM) are effective in improving the symptoms of degenerative patients. However, herbs or compounds with dual functions are unverified. The purpose of this study was to find a kidney-tonifying TCM that synchronously improved the differentiation and proliferation of oligodendrocyte precursor cells under pathological conditions. Compounds with dual functions were screened from highly frequently used kidney-tonifying TCM, and the effects of the obtained compound on remyelination were investigated in an in vitro oligodendrocyte precursor cell differentiation model under pathological conditions and in demyelinating mice in vivo. The compound icaritin, which is an active component of Yin-Yang-Huo (the leaves of Epimedium brevicornu Maxim), demonstrated multiple effects on the remyelination process, including enhancing oligodendrocyte precursor cell proliferation, facilitating the differentiation of neural progenitor cells toward oligodendrocyte precursor cells and further toward oligodendrocytes, and maturation of oligodendrocytes under corticosterone- or glutamate-induced pathological conditions. Importantly, icaritin effectively rescued behavioral functions and increased the formation of myelin in a cuprizone-induced demyelination mouse model. The multiple effects of icaritin make it a promising lead compound for remyelination therapy.
Improving Blueberry Anthocyanins’ Stability Using a Ferritin Nanocarrier
Authors: Huang Wuyang , Zhao Xingyu , Chai Zhi , Herrera-Balandrano Daniela D. , Li Bin , Yang Yiyun , Lu Shan , Tu Zhigang
Published: August 2023

Blueberries are fruits known for their high level of anthocyanins, which have high nutritional value and several biological properties. However, the chemical instability of anthocyanins is one of the major limitations of their application. The stability of blueberry anthocyanin extracts (BAEs) encapsulated in a ferritin nanocarrier was investigated in this study for several influencing parameters, including pH, temperature, UV–visible light, redox agents, and various metal ions. The outcomes supported the positive role of protein nanoparticles in enhancing the stability of blueberry anthocyanins by demonstrating that the stability of encapsulated BAE nanoparticles with ferritin carriers was significantly higher than that of free BAEs and a mixture of BAEs and ferritin carriers. This study provides an alternative approach for enhancing blueberry anthocyanin stability using ferritin nanocarrier encapsulation.
A Ratiometric Fluorescent Probe Based on RhB Functionalized Tb-MOFs for the Continuous Visual Detection of Fe3+ and AA
Authors: Jiang Xin , Li Wenwei , Liu Min , Yang Jie , Liu Mengjiao , Gao Daojiang , Li Hongda , Ning Zhanglei
Published: August 2023

In this study, a red-green dual-emitting fluorescent composite (RhB@MOFs) was constructed by introducing the red-emitting organic fluorescent dye rhodamine B (RhB) into metal-organic frameworks (Tb-MOFs). The sample can be used as a ratiometric fluorescent probe, which not only avoids errors caused by instrument and environmental instability but also has multiple applications in detection. The results indicated that the RhB@MOFs exhibited a turned-off response toward Fe3+ and a turned-on response for the continuous detection of ascorbic acid (AA). This ratiometric fluorescent probe possessed high sensitivity and excellent selectivity in the continuous determination of Fe3+ and AA. It is worth mentioning that remarkable fluorescence change could be clearly observed by the naked eye under a UV lamp, which is more convenient in applications. In addition, the mechanisms of Fe3+- and AA-induced fluorescence quench and recovery are discussed in detail. This ratiometric probe displayed outstanding recognition of heavy metal ions and biomolecules, providing potential applications for water quality monitoring and biomolecule determination.
The Comparison of Honey Enriched with Laboratory Fermented Pollen vs. Natural Bee Bread in Terms of Nutritional and Antioxidant Properties, Protein In Vitro Bioaccessibility, and Its Genoprotective Effect in Yeast Cells
Authors: Miłek Michał , Mołoń Mateusz , Kielar Patrycja , Sidor Ewelina , Bocian Aleksandra , Marciniak-Lukasiak Katarzyna , Pasternakiewicz Anna , Dżugan Małgorzata
Published: August 2023

The aim of the study was to compare the nutritional value and bioactivity of honey enriched with a 10% addition of natural bee bread and its substitutes obtained as a result of laboratory fermentation of bee pollen. Physicochemical parameters, antioxidant properties, as well as the bioaccessibility of proteins using an in vitro static digestion model were analyzed. The bioactivity of the obtained enriched honeys was tested using the yeast model. The research indicates the similarity of honeys with the addition of “artificial bee bread” to honey with natural ones. During in vitro digestion, good bioaccessibility of the protein from the tested products was demonstrated. The ability of the products to protect yeast cells against hydrogen superoxide-induced oxidative stress was demonstrated using a qualitative spot test, which was stronger in the case of enriched honey than in pure rapeseed control honey. Significant inhibition of the growth of both strains of yeast exposed to bee pollen-enriched honeys was also demonstrated. Furthermore, all tested samples showed significant genoprotective activity against the genotoxic effect of zeocin and the reduction of the number of DNA double-strand breaks by a minimum of 70% was observed.
Wetting Behaviour of Water, Ethanol, Rhamnolipid, and Triton X-165 Mixture in the Polymer–Solution Drop–Air System
Authors: Zdziennicka Anna , Rekiel Edyta , Szymczyk Katarzyna , Zdziennicki Wojciech , Jańczuk Bronisław
Published: August 2023

Despite the fact that the wetting properties of multicomponent mixtures including the surface active compounds play a very important role in many practical applications, they are not sufficiently known. Thus, the wettability of polytetrafluoroethylene (PTFE) and poly (methyl methacrylate) (PMMA) by the water + ethanol (ET) solution of rhamnolipid (RL) with Triton X-165 (TX165) mixture was studied. The investigations involved measuring the advancing contact angles of this solution on PTFE and PMMA by varying the concentration of TX165 while maintaining a constant concentration of ET and RL. Additionally, a thermodynamic analysis was conducted to obtain the compositions and concentrations of the ET, RL, and TX165 mixtures at the different interfaces. The composition and concentration of the interface mixed layer were considered using two different approaches to the wetting process. From these considerations, it follows that, depending on the ET concentration, it is possible to form the TX165 + RL layer at the solid–water + ET mixed solvent, as well as the water + ET–air interfaces, but not at the solid–water and water–air ones. This conclusion is in accordance with the Gibbs standard free energy of adsorption of particular components of the studied mixture at the solution–air and solid–solution interfaces.
An Exploration of Biophilic Design Features within Preschool Interiors
Authors: Mohammed Ibtisam , Onur Zeynep , Çağnan Çiğdem
Published: August 2023

This study examined the incorporation of biophilic elements in Duhok preschool interiors and integrated them into the Biophilic Interior Design Matrix (BID-M). This approach holds great promise for the development of restorative environments. The Biophilic Design Matrix (BDM) is based on Kellert’s list of biophilic design attributes, adjusted to suit preschool interiors. Photos and plan drawings were employed as methods to analyze 59 interior spaces within six preschools, both private and public. The biophilic matrix revealed the presence of 30% of biophilic attributes in the analyzed spaces, with an average score of 16.45 out of 53 total points. Individual scores ranged from 8 to 22 for each space, highlighting variations in biophilic design within the six preschools. Notably, the study identified a lack of biophilic features that foster human–nature relationships in the majority of preschools, albeit minimally observed in some spaces. Conversely, the environmental features scored higher than the average. This research highlights the importance of enhancing biophilic design elements, especially those that strengthen human–nature relationships. The results enhance biophilic design in educational settings, promoting nature-centered, restorative environments for future interventions. Furthermore, we propose an innovative approach for assessing and incorporating biophilia in interiors, recognizing its positive impact on human health and wellbeing.
Could the Comfort Zone Model Enhance Job Role Clarity in Youth Work? Insights from an Ethnographic Case Study of the United Kingdom-Based National Citizen Service
Authors: Godfrey Nigel Mark
Published: August 2023

A convention in outdoor adventure education leadership is to stretch participants beyond their comfort zone to optimize engagement and learning. This article explores how an interpretation of the comfort zone model (CZM) might potentially enhance job role clarity within the youth work (YW) field. The CZM emerged as a strong theme from an ethnographic case study of the United Kingdom government’s flagship youth policy, the National Citizen Service (NCS). The findings indicate that the CZM has the potential to reinforce Dewey-derived YW principles and enhance young people’s social skills, self-esteem, confidence, and resilience. However, applying the CZM to YW practice presents risks such as misunderstandings, coercion, and overstretching. Further research should consider factors such as staff training, mental health, and welfare concerns, as well as the implications and limitations of integrating the CZM within the YW field.
What is the deadline in accordance with the Constitution by which the President must appoint to а Prime-minister candidate a mandate for formation of a regular Government
Authors: Slavov Peter
Published: August 2023

This article provides an analysis of case with the possible delay of the deadline within which the President of the Republic is obliged to appoint a mandate for formation of a Government as to art. 99. There is no explicit deadline in the Constitution, by which the latter must appoint the mandate, as e.g. he is obliged by art. 75 to convene the newly elected Parliament within 1-month-term. The case is especially important as there is no practice of the Constitutional Court on this matter, while there are quite a few rulings on the other aspects of art. 99 and the applicable terms after the first mandate has been appointed. While there are also some gaps in the constitutional framework, the Constitutional Court has adopted the term “reasonable term”, beyond which any delay shall be in contradiction with the Constitution. Precisely this “reasonability” in the context of appointing the first mandate will be analysed, in the context of the entire constitutional regulation of art. 99 for forming a regular Government but also in the spirit of a parliamentary Republic.
Health monitoring system for Nordic walking
Authors:   I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Lebed O. L. , Kiseleva N. I. ,   I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Published: August 2023

This article discusses an analytical approach to writing user and system requirements for the Nordic Walking Health Monitoring System and describes the tools which allow designing this web-based system.
The effectiveness of medical personnel vaccination against hepatitis B
Authors:   S. P. Botkin City Clinical Hospital, Moscow Healthcare Department, Moscow, Russia, Nikitina G. Y. , Orlova O. A. ,   National Medical and Surgical Center named after N. I. Pirogov of the Ministry of Health of the Russian Federation, Moscow, Russia, Semenenko A. V. ,   The National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russia, Shavlova E. O. ,   S. P. Botkin City Clinical Hospital, Moscow Healthcare Department, Moscow, Russia, Gotvyanskaya T. P. ,   The National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russia
Published: August 2023

Medical personnel belong to the occupational risk group of hepatitis B virus (HBV) infection due to the increase of parenteral interventions and procedures using sophisticated equipment, constant contact with biological fluids of patients, the widespread use of antibiotics and cytostatics that have an immunosuppressive effect, etc. Insufficient objectivity in assessing the quality of hepatitis B (HBV) immunoprophylaxis only according to documentation may be associated with a violation of immunization regimens, the presence of chronic pathology in vaccinated, age-related immunodeficiency. Despite the effectiveness of HCV vaccination, the protective activity of specific humoral immunity (antibodies to HBsAg — anti-HBs) among vaccinated medical workers has not been sufficiently studied. The results of studying the intensity and duration of the immune response in 2075 employees of two large multidisciplinary hospitals vaccinated against HBV (average age 46.3 ± 10.1 years) are presented. A high level of vaccination coverage of medical personnel in hospitals No. 1 and No. 2 was established, amounting to 96.6 % and 97.2 %, and the level of collective immunity was equal to 1645.5±72.5 IU/l and 886±123.7 IU/l, respectively. The absence of cases of HBV in vaccinated individuals during immunoprophylaxis according to the standard scheme was noted. It seems advisable to use an individual approach to the tactics of revaccination when reducing the content of anti-HBs in the blood to low concentrations (10–100 IU / l), preventing them from falling below the protective level.
Assessment of the state of non-specific resistance of the body of military personnel according to the leukogram in various professional activities in the Arctic
Authors:   Volga Research Medical Universit y of the Ministry of Health of Russia, Nizhny Novgorod, Rachmanov R. S. , Bogomolova E. S. ,   Volga Research Medical Universit y of the Ministry of Health of Russia, Nizhny Novgorod, Nurutdinov D. A. ,   Krasnoyarsk State Medical Universit y named after prof. V. F. Voyno-Yasenetsky of the Ministry of Health of Russia, Krasnoyarsk, Razgulin S. A. ,   Volga Research Medical Universit y of the Ministry of Health of Russia, Nizhny Novgorod, Podeeva T. V. ,   Volga Research Medical Universit y of the Ministry of Health of Russia, Nizhny Novgorod, Neprashin D. V. ,   Volga Research Medical Universit y of the Ministry of Health of Russia, Nizhny Novgorod
Published: August 2023

A comparative analysis of the state of non-specific resistance of the body in military personnel serving under a contract, divided into groups according to the principle of work probation (with different duration of professional activity in the Arctic): up to 5 (n = 21) and up to 10 years (n = 30) years, by leukocyte index. According to the leukogram, leukocyte indices (ratios) were calculated: neutrophils/lymphocytes (NIL), lymphocytes/neutrophils (LI), lymphocytes/monocytes (ILM), neutrophils/monocytes (NIL), lymphocytes/eosinophils (ISLE), monocytes/lymphocytes (ML), lymphocytes/to the percentage of segmented neutrophils (IG), the sum of eosinophils and lymphocytes/monocytes — immunoreactivity of the organism (IIR). We established the presence of statistically significant differences in 5 indices out of 9 determined. ISLM in group No. 2 was higher by 7.0 %, ISMI — by 7.8 %, ISLE — by 29.6 %, IIR — by 4.2 %. According to the indicators of IG, MLI, IIR, the level of immune defense of the body of military personnel was within the normal range. The conditions of activity in the Arctic had a negative impact on the humoral and cellular immunity (LI), phagocytic activity of cells (CMI). Leukocyte indices (ISLM, ISNL, ISLE, IIR) testified that in persons with a longer period of professional activity, the level of adaptation of the organism to extreme living conditions is higher. Leukocyte indices revealed the features of the state of the protective functions of the body of military personnel during work in the Arctic, they are informative. Carrying out blood tests, in terms of assessing leukograms in extreme conditions, allows you to use these studies in the form of express methods.
ANALISIS GRAVITY LOCATION MODEL DALAM PENENTUAN LOKASI GUDANG PADA SUPPLY CHAIN MANAGEMENT
Authors: Susanto Rani
Published: August 2023

Kegiatan distribusi barang merupakan salah satu kegiatan dalam perancangan jaringan supply chain management. Kegiatan ini bertujuan agar produk yang dikirimkan tepat waktu dengan ongkos yang minimal. Dalam kegiatan pendistribusian, penempatan sumber pasokan dengan lokasi fasilitas memiliki peranan penting untuk memastikan barang bisa terkirim dengan baik kepada pelanggan. Jarak antara sumber pasokan dengan lokasi fasilitas yang relatif jauh menyebabkan ongkos transportasi menjadi semakin membengkak. PT. X merupakan perusahaan yang menerapkan jaringan supply chain pada perusahaannya dalam pemenuhan kebutuhan barang setiap kantor cabangnya. Lokasi cabang yang saling berjauhan dan kebutuhan barang yang berbeda-beda menyebabkan total ongkos (cost) semakin membengkak. Maka  dari itu perusahaan membutuhkan rekomendasi lokasi fasilitas gudang penyimpanan barang untuk kebutuhan distribusi dengan lokasi yang paling optimal dan total ongkos yang minimal. Metode Gravity Location Model digunakan untuk menentukan lokasi yang akan menjadi penghubung antara sumber pasokan dengan lokasi fasilitas terkait. Model ini mempertimbangkan asumsi jika ongkos akan naik sesuai dengan volume yang dipindahkan dan penentuan koordinat x,y sebagai penentu lokasi. Hasil penelitian ini menyatakan bahwa   titik koordinat yang paling optimal yang akan menjadi lokasi fasilitas gudang baru total ongkos (cost) sebesar Rp888.611. Dengan hasil tersebut, perusahaan mendapatkan rekomendasi lokasi fasilitas gudang yang paling optimal untuk memenuhi kebutuhan barang disetiap kantor cabangnya.

 Kata Kunci: supply chain management, distribusi, Gravity Location Model

perusahaan ini yaitu pada titik (0,5;1,9) dengan
Rancang Bangun Sistem Informasi Point of Sale (POS) Berbasis Web (Studi Kasus Toko Andorio)
Authors: Mulyana Agus , Rusmawan Uus
Published: August 2023

Proses manajemen penjualan yang saat ini berjalan di Toko Andorio masih menggunakan metode tradisional atau konvensional. Metode seperti ini kurang efisien dan efektif karena melibatkan penggunaan banyak buku nota dan tulisan manual. Pembuatan laporan juga memakan waktu karena harus menyalin data dari nota penjualan. Tujuan dari penelitian ini adalah mengembangkan sistem informasi Point Of Sale (POS) sebagai sarana untuk meningkatkan efisiensi dan efektivitas dalam proses penjualan dan pembuatan laporan di Toko Andorio. Dalam penelitian ini, metode perancangan aplikasi yang diterapkan adalah metode Waterfall, Waterfall merupakan salah satu metode Rekayasa Perangkat Lunak. Proses perancangan aplikasi ini dilakukan secara berurutan, dimulai dengan melakukan analisis kebutuhan, merancang sistem, melakukan implementasi dan pengujian, menerapkan program, dan terakhir adalah pemeliharaan. Bahasa pemrograman yang digunakan adalah PHP, dengan database MySQL. Hasil dari penelitian ini adalah Aplikasi sistem informasi Point Of Sale berbasis web yang dapat digunakan untuk memudahkan kegiatan oprasional Toko Andorio mulai dari proses transaksi seperti pembelian dan penjualan, serta memudahkan dalam rekapitulasi laporan seperti laporan pembelian, penjualan dan laporan stok.

Kata Kunci: MYSQL, PHP, Point of sale, Waterfall
Features of statistical accounting of service dogs of the Federal Penitentiary Service of Russia: on the issue of combating the penetration of prohibited items
Authors: Zanegina N. V.
Published: August 2023

The article presents part of the results obtained during a scientific study that was conducted in 2022 at the Research Institute of Information Technologies of Federal Penitentiary Service to improve the effectiveness of departmental statistical monitoring in the field of organizing the work of the security service to ensure the security of institutions of the penitentiary system. The publication provides a justification for the need to adjust statistical indicators of the form of departmental statistical reporting, which contains information on the results of the official activities of the canine units of the penal system within the second section informing the Department of Protection and Escort of the Federal Penitentiary Service about the service dogs of institutions. The publication contains information about the reasons and content of the changes in the specified form of departmental statistical reporting. The article notes the importance, relevance, and timeliness of adjusting statistical indicators that are used to monitor the effectiveness of the canine units of Federal Penitentiary Service of Russia, as well as for analysis, planning, modeling, and implementation of the main directions of management activities in this area.
Quasi-periodic development of the economy
Authors: Kuzentsov S. B.
Published: August 2023

The article considers the mathematical definition of the space of states of the macroeconomy, where each point represents a certain distribution of the growth of the main factors of production – labor, capital, and natural resources. We study the violation of the sustainable regime of economic development, described by the system of differential equations in partial derivatives. The phenomenon of stable development of the economy, as well as the presence of more than one stable regime of economic development, depending on political and international factors, is studied. The role of periodic development in the economy and the existence of multiple attractors that create various stable regimes are considered in detail. The various stable regimes that arise are solutions of non-linear differential equations. We study the process of the emergence of instability, when the economic number that defines a particular economy continues to increase after reaching its first critical value. A further increase in the economic number leads to the fact that periodic development becomes unsustainable. The trajectory analysis of production factors is performed by the method presented by L.D. Landau and E.M. Lifshitz. The emerging stabilization of the economy can be broken again as the economic number approaches the next critical value; instability reappears with the advent of a new frequency. After passing through several critical values of the economic number, a stable limit cycle can appear on the torus, which is a geometric interpretation of the trajectories of economic development. The appearance of a stable limit cycle means the manifestation of synchronization of oscillations the disappearance of the quasi-periodic and the establishment of a new periodic motion. The birth of a stable limit cycle prevents the emergence of a regime of superpositions of motions of trajectories with many incommensurable frequencies.
Mitreu de Londinium e a escavação de dois impérios
Authors: Pinto Renato
Published: August 2023

A descoberta do Mitreu de Londinium em 1952 foi um importante marco na reconstrução de Londres após os bombardeios da Segunda Guerra Mundial. Vindo do mundo helenístico, o mitraísmo chegou à Britânia (Britannia), província do Império Romano, no séc. II d.C. já ressignificado, voltado aos militares, mercadores e ricos libertos. O templo dedicado a Mitra foi construído no início do séc. III e durou até meados do IV, simbolizando resistência aos ataques do cristianismo e, possivelmente, sendo reconsagrado a outra divindade. A escavação do templo e os achados arqueológicos no séc. XX no seu interior levaram muitos britânicos a conectar os vestígios de um império da Antiguidade com a ansiedade relacionada aos estertores do seu império moderno. Apesar do sucesso do Mitreu na modernidade, sua trajetória arqueológica é complexa e envolve as pressões imobiliárias de uma grande cidade como Londres e o papel de museus e da iniciativa privada na guarda do patrimônio arqueológico do passado.
Conquista romana da Hispânia Citerior
Authors: Carreras Cesar , Catarineu Laia , Rodrigo Esther , Romani Núria , Pera Joaquim
Published: August 2023

A conquista romana da Península Ibérica, e mais precisamente do território que viria a ser a província da Hispânia Citerior, tem suscitado um interesse particular nos últimos anos. Intervenções arqueológicas preencheram uma lacuna no conhecimento da atividade militar dos séculos II-I a.C., que basicamente só era conhecida através de fontes antigas. Graças ao trabalho contínuo de várias equipas de investigação, temos atualmente um panorama completamente diferente. Nestas novas investigações sobre o primeiro século da conquista romana da Península, o século II a.C., que há poucas décadas era um período completamente desconhecido, surge como um período crucial para propor novas hipóteses sobre o modelo romano de conquista deste território do norte peninsular. Este modelo de conquista foi seguramente aplicado, com algumas nuanças, aos outros territórios que viriam a constituir o futuro Império Romano.
Sustainable Development Goals: Challenges and the Role of the International Society of Nephrology in Improving Global Kidney Health
Authors: Karam Sabine , Wong Michelle M.Y. , Jha Vivekanand
Published: August 2023

The United Nations 2030 agenda for sustainable development includes 17 sustainable development goals (SDGs) that represent a universal call to end poverty and protect the planet, and are intended to guide government and private sector policies for international cooperation and optimal mobilization of resources. At the core of their achievement is reducing mortality by improving the global burden of noncommunicable diseases (NCDs), the leading causes of death and disability worldwide. CKD is the only NCD with a consistently rising age-adjusted mortality rate and is rising steadily up the list of the causes of lives lost globally. Kidney disease is strongly affected by social determinants of health, with a strong interplay between CKD incidence and progression and other NCDs and SDGs. Tackling the shared CKD and NCD risk factors will help with progress toward the SDGs and vice versa. Challenges to global kidney health include both preexisting socioeconomic factors and natural and human-induced disasters, many of which are intended to be addressed through actions proposed in the sustainable development agenda. Opportunities to address these challenges include public health policies focused on integrated kidney care, kidney disease surveillance, building strategic partnerships, building workforce capacity, harnessing technology and virtual platforms, advocacy/public awareness campaigns, translational and implementation research, and environmentally sustainable kidney care.
Publications Highlight Science Communication Research for Busy Professionals
Authors: Crone Joseph
Published: August 2023

Professionals, such as Extension personnel, who communicate with a range of non-specialists about scientific or technical information face particular challenges. A common goal of all such professionals is to effect at least some change in their audiences' understanding and perhaps in their actions. A key challenge for many of these professionals is a lack of familiarity with research relating to communicating and making decisions about scientific and technical topics. Public Science Communication Research and Practice, a series of publications from Oregon State University, is designed to identify, distill, and highlight useful social science research to help professionals communicate more effectively.
Disengaging a Volunteer: What to Do When Supervision Fails
Authors: Culp Ken , Doyle Joyce
Published: August 2023

Eventually, most Extension professionals will need to disengage a volunteer. The decision to disengage a volunteer should be a last resort. Disengagement is an admission that volunteer supervision has failed. Useful alternatives to and steps in avoiding volunteer disengagement are provided. A systematic approach for disengaging volunteers is presented.
Assessing the Culture of Fresh Produce Safety Within a Leafy Green Producing Community
Authors: Nolte Kurt , Sanchez Charles , Fonseca Jorge
Published: August 2023

The 2006 Escherichia coli outbreak in spinach prompted the implementation of unprecedented production strategies (Arizona Leafy Green Products Shipper Marketing Agreement) to minimize microbial risk in leafy greens. As the new procedures require assessments of physical intrusion and excrement in fields, outreach was initiated to educate adult (20-35, 35-50, and > 50 years) Yuma, Arizona residents about these guidelines and animal (e.g., pets, horses) stewardship. Pre- and post-assessments revealed that while sensitivity to fresh produce safety improved, adults over 35 years were more industry responsive. Citizen-based outreach programs, in communities where fresh produce is grown, could benefit field-level safety mitigation.
Extension's Role in Developing a Farmers' Market
Authors: Civittolo David
Published: August 2023

Interest in access to local food is increasing. Communities of all types and sizes have volunteers interested in creating farmers' markets. Extension can play an important role in the development of farmers' markets because it is ideally suited to organize and coordinate these volunteer energies. By helping community volunteers focus their efforts, Extension enabled volunteers, community leaders, and residents to realize the benefits of creating a farmers' market. This article discusses a process for developing a community farmers' market and the roles that Extension has played.
On Reviewing and Writing a Scholarly Article
Authors: Bettis Jerry
Published: August 2023

This article provides guidelines for reviewing and writing scholarly articles for the professional who reads and writes them for his/her own work and/or for publication in scientific journals. It outlines the purpose and contents of each section of a research article and provides a checklist for reviewing and writing a research article. This article is intended for use by authors, reviewers, Extension workers, graduate students, and neophyte scientists when reviewing and writing a scholarly article. The reviewer has the responsibility to determine and demand quality, and by doing so quality will result.
Tratamento de maxila atrófica com implante personalizado: relato de caso
Authors: Da Maia Renan Prado Reis , Nascimento Ramon dos Santos , Ibanez Rafaella Brandão , Marins Luci Santos , Rivas Marcos Vidal , Cova Júlio César Pereira
Published: August 2023

Atualmente, um dos maiores desafios para a implantodontia é reestabelecer e reconstruir as funções fisiológicas, estéticas e fonéticas em maxilas atróficas. Quando o nível ósseo do paciente não permite a instalação dos implantes convencionais, o tratamento de reabilitação pode ser realizado através dos procedimentos cirúrgicos reabilitadores, utilizando a tecnologia customizada, fabricada a base de titânio, a partir de análise computadorizada de toda a anatomia bucomaxilofacial do paciente. Neste trabalho é relatar um caso de uma paciente com perda óssea severa em região maxilar, sendo feita a reconstrução utilizando a precisão da Prótese Customizada da Maxila para Reabilitação Protética implantossuportada.
Condição física e rendimento académico na adolescência
Authors: Guilherme José , Martins Carla , Nunes Maria Cristina de Oliveira Salgado , De Jesus Saul Neves
Published: August 2023

Conhecer as relações entre a condição física e o rendimento académico, assim como equacionar esta relação a nível das variáveis sexo e idade dos adolescentes, constitui uma questão atual e fulcral no ensino, no desporto e na sociedade. A amostra do presente estudo é constituída por 1358 participantes da região do Algarve, sendo 724 (53,31%) do sexo feminino. A idade está compreendida entre os 12 e os 17 anos. A Condição Física foi avaliada mediante o Fitnessgram. O rendimento académico foi obtido a partir da média aritmética do curriculum. Verificou-se que no global da amostra, sexo feminino e masculino, existem diferenças estatisticamente significativas entre as médias escolares (rendimento académico) e os grupos critério da condição física. As médias do rendimento académico entre o sexo masculino e feminino, não apresentam diferenças estatisticamente significativas. A idade não parece constituir variável preditora no rendimento académico dos participantes no presente estudo.
Tendência da mortalidade por Câncer Colorretal no estado do Piauí e Brasil no período de 2016 a 2020
Authors: De Mesquita Neto Antonio Martins , Silva Lorenna Martins , Muniz Alexandra Ferreira Nery , Diniz Thiago Pereira
Published: August 2023

O câncer de colorretal é uma causa significativa da morbimortalidade no mundo. No Brasil, o câncer de cólon e reto é o segundo tipo de neoplasia mais incidente em ambos os sexos. Esta pesquisa tem como objetivo realizar uma análise estatística e descritiva dos dados de mortalidade por câncer colorretal no Estado do Piauí e no Brasil entre os anos de 2016 a 2020. Foi realizado um estudo com estatísticas descritivas, de série temporal, sobre casos e mortalidade por câncer colorretal no Piauí e no Brasil entre 2016 a 2020, com os dados retirados do Departamento de Informática do Sistema Único de Saúde (DATASUS). Os dados obtidos foram processados no programa Microsoft Excel. Neste estudo, foi observado aumento no número de casos em ambos os sexos no Piauí e no Brasil, seguindo uma tendência linear, apesar da diminuição de 2019 para 2020. A proporção de novos casos entre os sexos se manteve aproximadamente constante, no Piauí e no Brasil e de acordo com o avanço da idade. Ademais, o número de óbitos apresentou uma tendência de diminuição no Piauí, e no Brasil, continua com uma tendência de crescimento, sendo menor que o aumento de casos. É possível mencionar a razão de mortalidade apresentou tendência de diminuição ao longo dos anos no Piauí e no Brasil. Contudo, esta pesquisa contribuiu para comunidade científica, a fim de promover a saúde e conscientizar sobre a necessidade de realizar estudos futuros e mais detalhados sobre essa temática.
Compostos bioativos e propriedades funcionais de espécies frutíferas cultivadas no Brasil
Authors: Mesquita Fernanda Lôbo Oliveira , Ribeiro Jéssica Souza , Viana Eduardo Bruno Macêdo , Zanuto Marcia Elena , De Souza Cassiara Camelo Eloi
Published: August 2023

O presente trabalho teve como objetivo reunir, sistematizar e discutir os mais recentes estudos que abordam sobre os compostos bioativos e/ou as propriedades funcionais biológicas de espécies vegetais cultivadas no Brasil. A maioria dos estudos envolveram as famílias Anacardiaceae, Arecaceae, Annonaceae, Apocynaceae, Caryocaraceae, Clusiaceae, Fabaceae, Malpighiaceae, Myrtaceae Rubiaceae, Oxalidaceae, Olacaceae, Passifloraceae e Solanaceae. Dentre as propriedades funcionais observadas nos estudos, verificou-se a descrição das atividades antienvelhecimento, antiproliferativa, imunomoduladora, antimicrobiana, antiobesidade e, principalmente, antioxidante, comuns em grande parte das espécies, indicando o seu potencial para desenvolvimento de produtos voltados à promoção da saúde.