bluuebunny/crossref_metadata_2025 huggingface dataset:
An Open-Label Clinical Trial of Oral Transmucosal Haloperidol and Olanzapine in the Treatment of Terminal Delirium
Authors: Lyu Xiao Juan , Kan Adrian David , Chong Poh Heng , Lin Keegan , Koh Yung Hua , Yeo Zhi Zheng
Published: December 2021

Background : The phenomenon of restlessness, agitation, or cognitive disturbances experienced by dying patients is well-known in palliative care; more than half of these patients will experience delirium symptoms at end-of-life. When not identified early and effectively managed, delirium symptoms could lead to caregiver and patient distress and harm. Methods : 80 patients with a prognosis of 3 days or less will be recruited for an open-label randomized control trial. The two arms compare oral-transmucosal haloperidol 2.5mg vs olanzapine 5mg over 72 hours. The severity of agitation, delirium and toxicities of treatments will be compared at the 24 th , 48 th and 72 nd hour after drug administration. Discussion : This trial is the first to compare anti-psychotics in the management of delirium at the dying stage in the home hospice setting using the oral transmucosal route. Ethical considerations, as well as recruitment procedures are discussed. Trial registration : ClinicalTrials.gov, NCT04750395. Registered 11 February 2021, https://clinicaltrials.gov/ct2/show/NCT04750395
Association of Sonographic Features of Unifocal Papillary Thyroid Carcinoma With Cervical Lymph Node Metastasis
Authors: Zhou Liuhua , Zhu Qiaodan , Yao Jincao , Yang Chen , Xu Dong
Published: December 2021

Background Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid carcinoma. We aim to evaluate the association of sonographic features of PTC and cervical lymph node metastasis (CLNM) at the initial surgery. Methods Clinical information, ultrasonographic measurements and features for 1335 patients were acquired in data collection. Univariate analysis was performed to test CLNM by 7 independent variables. Receiver operating characteristic (ROC) curve was created to evaluate the diagnostic performance. Results Univariate analysis showed that gland, location, aspect ratio, margin and echogenic foci were independently associated with CLNM metastatic status (P<0.05). Binary linear regression analysis showed that sex, age, tumour maximum diameter and volume, location, margin and echogenic foci were independent correlative factors. The ROC curves were established based on the relevant factors, the AUC of tumour maximum diameter, tumour volume and margin were 0.74, 0.73, and 0.71, respectively. The multiple-variable linear regression model was constructed with AUC of 0.81, specificity of 72.8%, and sensitivity of 75.0%. ANOVA variance analysis for sub-positive groups, tumour maximum diameter, tumour volume, margin and echogenic foci had statistical significance (P<0.05).Conclusion Younger age, male, larger tumour, margin, and echogenic foci were high risk factors for CLNM in PTC. Cross-sectional aspect ratio with value≥1 had higher predictive value for CLNM in patients with larger thyroid tumors.
Aquaporin-4 Expression in the Human Choroid Plexus
Authors: Deffner Felix , Gleiser Corinna , Mattheus Ulrich , Wagner Andreas , Neckel Peter H , Fallier-Becker Petra , Hirt Bernhard , Mack Andreas F
Published: December 2021

The choroid plexus (CP) consists of specialized ependymal cells and underlying blood vessels and stroma producing the bulk of the cerebrospinal fluid (CSF). CP epithelial cells are considered the site of the internal blood-cerebrospinal fluid barrier, show epithelial characteristics (basal lamina, tight junctions), and express aquaporin-1 (AQP1) apically. In this study, we analyzed the expression of aquaporins in the human CP using immunofluorescence and qPCR. As previously reported, AQP1 was expressed apically in CP epithelial cells. Surprisingly, and previously unknown, many cells in the CP epithelium were also positive for aquaporin-4 (AQP4), normally restricted to ventricle-lining ependymal cells and astrocytes in the brain. Expression of AQP1 and AQP4 was found in the CP of all eight body donors investigated (3 males, 5 females; age 74-91). These results were confirmed by qPCR, and by electron microscopy detecting orthogonal arrays of particles. To find out whether AQP4 expression correlated with the expression pattern of relevant transport-related proteins we also investigated expression of NKCC1, and Na/K-ATPase. Immunostaining with NKCC1 was similar to AQP1 and revealed no particular pattern related to AQP4. Co-staining of AQP4 and Na/K-ATPase indicated a trend for an inverse correlation of their expression. We hypothesized that AQP4 expression in the CP was caused by age-related changes. To address this, we investigated mouse brains from young (2 months), adult (12 months) and old (30 months) mice. We found a significant increase of AQP4 on the mRNA level in old mice compared to young and adult animals. Taken together, we provide evidence for AQP4 expression in the CP of the aging brain which likely contributes to the water flow through the CP epithelium and CSF production. In two alternative hypotheses, we discuss this as a beneficial compensatory, or a detrimental mechanism influencing the previously observed CSF changes during aging.
Tumor-B-cell Interactions Promote Isotype Switching to an Immunosuppressive IgG4 Antibody Response Through Upregulation of IL-10 in Triple Negative Breast Cancers
Authors: Toney Nicole J. , Opdenaker Lynn M. , Cicek Kader , Frerichs Lisa , Kennington Christopher Ryan , Oberly Samuel , Archinal Hollis , Somasundaram Rajasekharan , Mourtada Jennifer Sims
Published: December 2021

BackgroundTriple negative breast cancer (TNBC) is an aggressive breast cancer for which there is currently no targeted therapy. Tumor-infiltrating B-cells (TIB) have been observed in tumor tissues of TNBC patients, but their functional role is unclear. IgG4 is one of four antibody subclasses of IgG expressed and secreted by B cells. Unlike other IgG isotypes, IgG4 has an immunosuppressive function and is induced by Th2-type cytokines. In cancers such as melanoma, IgG4 has been linked with advanced disease and poor patient survival. Therefore, we sought to determine the role of IgG4 in TNBC. MethodsWe performed co-culture assays to examine expression of Th2 cytokines by TNBC cells with and without the presence of B cells. We also performed in vitro class switching experiments with peripheral B cells with and without co-culture with TNBC cells in the presence or absence of an IL-10 blocking antibody. We examined expression of CD20 + TIB, IgG4 and Th2 cytokines by immunohistochemistry in 152 TNBC samples. Statistical analysis was done using Log-Rank and Cox-proportional hazards tests. ResultsOur findings indicate that B cells interact with TNBC to drive chronic inflammatory responses through increased expression of inflammatory cytokines including the TH2 cytokines IL-4 and IL-10. In vitro class switching studies show that interactions between TNBC cell lines and B cells drive isotype switching to the IgG4 isotype in an IL-10 dependent manner. In patient tissues, expression of IgG4 correlates with CD20 and tumor expression of IL-10. Both IgG4 and tumor IL-10 are associated to shorter recurrence free survival (RFS) and overall survival (OS) in TNBC. In a multi-variant analysis, IL-10 was associated with poor outcomes indicating that tumor IL-10 may drive immune escape. ConclusionsThese findings indicate that interactions between TIB and TNBC results in activation of chronic inflammatory signals that suppress antibody driven immune responses
Global Analysis of The Signalling Network of Breast Cancer Cells In Response To Progesterone.
Authors: Wright Roni H. G. , Vastolo Viviana , Oliete Javier Quilez , Carbonell-Caballero Jose , Beato Miguel
Published: December 2021

Background: Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit the external signal from the cell membrane to chromatin, ultimately leading to a change of the gene expression program. Although many of the events within the signalling network have been described in isolation, how they globally team up to generate the final cell response is unclear. Methods: In this study we used antibody microarrays and phosphoproteomics to reveal a dynamic global signalling map that reveals new key regulated proteins and phosphor-sites and links between previously known and novel pathways. T47D breast cancer cells were used, and phosphosites and pathways highlighted were validated using specific antibodies and phenotypic assays. Bioinformatic analysis revealed an enrichment in novel signalling pathways, a coordinated response between cellular compartments and protein complexes. Results: Detailed analysis of the data revealed intriguing changes in protein complexes involved in nuclear structure, epithelial to mesenchyme transition (EMT), cell adhesion, as well as transcription factors previously not associated with breast cancer proliferation. Pathway analysis confirmed the key role of MAPK following progesterone and additional hormone regulated phosphosites were identified. Full network analysis shows the activation of new signalling pathways previously not associated with progesterone signalling in breast cancer cells such as ERBB and TRK. As different post-translational modifications can mediate complex crosstalk mechanisms and massive PARylation is also rapidly induced by progestins, we provide details of important chromatin regulatory complexes containing both phosphorylated and PARylated proteins. Conclusions: This study contributes an important resource for the scientific community, as it identifies novel players and connections meaningful for breast cancer cell biology and potentially relevant for cancer management.
The Modulatory Role of Internet-Supported Mindfulness-Based Cognitive Therapy on Extracellular Vesicles and Psychological Distress in People Who Have Had Cancer: A Protocol for A Two-Armed Randomized Controlled Study
Authors: Pereira Diana , Silva Eunice R. , Carvalho-Maia Carina , Monteiro-Reis Sara , Lourenço Catarina , Calisto Rita , Teixeira Ricardo João , Carlson Linda E. , Bart Genevieve , Vainio Seppo J. , Sales M. Goreti F. , Jerónimo Carmen , Henrique Rui
Published: December 2021

BackgroundMindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized controlled trials (RCTs) have examined their effects upon biological parameters. Specifically, no previous study has examined the effects of MBIs on extracellular vesicles (EVs), which are potentially important markers of health, disease, and stress. Moreover, the lack of RCTs is even more limited within the context of technology-mediated MBIs and long-term effects.MethodsThe current study protocol presents a two-arm, parallel, randomized controlled study investigating the effects of internet-supported mindfulness-based cognitive therapy (MBCT) compared with treatment as usual (TAU). Primary outcomes are psychological distress and EV cargo of distressed participants with previous breast, colorectal, or prostate cancer diagnoses. Secondary outcomes are self-reported psychosocial and health-related measures, and additional biological markers. Outcomes will be assessed at baseline, 4 weeks after baseline (mid-point of the intervention), 8 weeks after baseline (immediately post-intervention), 24 weeks after baseline (after booster sessions), and 52 weeks after baseline. Our goal is to recruit at least 111 participants who have been diagnosed with breast, prostate, or colorectal cancer (cancer stage I to III), are between 18 and 65 years old, and have had primary cancer treatments completed between 3 months and 5 years ago. Half of the participants will be randomized to the TAU group and the other half will participate in an 8-week online MBCT intervention with weekly group sessions via videoconference. The intervention also includes asynchronous homework, an online retreat after the fifth week, and 4 monthly booster sessions after completion of the 8-week program.DiscussionThis study will allow characterizing the effects of internet-based MBCT on psychosocial and biological indicators in the context of cancer. The effects on circulating EVs will also be investigated, as a possible neurobiological pathway underlying mind-body intervention effects. Trial registration: NCT04727593 (date of registration: 27 January 2021; date of record verification: 6 October 2021; https://clinicaltrials.gov/ct2/show/NCT04727593).
Design and Development of HDPE Plastic Sheet Testing Machine
Authors: Jakukore Vidyanand , Shinde Sachin
Published: December 2021

In this work main objective is to check the quality of plastic sheet paper of different companies and suggest best of one, so that farmers in India should know the quality and get awareness about the plastic sheet paper .This test method may be used to test all plastics within the thickness range described and the capacity of the machine employed. At this checking of tensile strength all size of sheet paper was performed. This tensile test measure the force required to break a specimen and extent to which the specimen stretches or elongate that braking point.
Design and Analysis of Ultrasonic Polypropene Corrugated Box Welding Machine
Authors: Kaveri V R , Gaikwad A B , Utpat A A
Published: December 2021

A wide style of ultrasonic corrugated plastic box welding machine options are available to you. Ultrasonic Polypropene corrugated box welders as a special purpose machine for variable sizes of Polypropene boxes that is a no bench type-welding machine to weld pp boxes is made with innovative technology at its perfection. “SANITEK PLASTOWELD SOLUTION” are a reliable manufacturer, trader, importer and exporter of the industry and established within the year 2010. They are the favoured name within the market place for providing very best quality assortment of plastic welding machine box, ultrasonic handgun, ultrasonic tube sealing machines and plenty of more products are designed and made by them. Ultrasonic welding provides good welding aesthetics. Manufacturing of ultrasonic Polypropene box welding machine is obtainable by “SANITEK PLASTOWELD SOLUTION”. No scratch guarantee for packed items. Polypropene corrugated boxes are nowadays used more as compare to the normal corrugated boxes, which were stapled and now corrugated box are joint by using ultrasonic welding. There is less rejection of packing items. A large form of ultrasonic Polypropene corrugated box welding machine options are available to you. No corrosion of joints means healthy packaging. This machine can weld one or more welding spot together which make it production friendly. With vision to sale its products in larger base company has laid emphasis on research. These are specifically designed to confirm easy handling reliable welding results, reproducibility while advancing, and optimizing the machine.
Setudnyan Application
Authors: Kulkarni S. M , Bhuite S. R , Gangamwar O. H , Randive S. S
Published: December 2021

In today’s situation people do not want to come outside their home and make close contact to other people due to this COVID-19 virus. So our purpose is to providing the one informative platform to such users. The Setudnyan Application will play a very significant role in rural areas where people don’t understand the English language well. It will help to those people to understand the different processes for How to get the different government certificates or prerequisite of Sub-documents. This application will help or provides all the information related to documents like income Certificate, Caste Certificate, Farmer Certificate, etc. This application also provides information or different portals link of different government schemes. All users first create an account first, and then they can login through id and password.
Study of Different Positions of Sprinklers for Irrigation System
Authors: Motewar Aditya , Patil Rushikesh , Khandagale Rohit , Bansode Dnyaneshwar , Wangikar Sandeep S
Published: December 2021

The use of sprinkler is becoming prevalent day by day. A sprinkler system should be designed to apply water homogeneously without erosion or runoff. The sprinkler application rate of the system should be harmonized to the infiltration rate of the most restrictive soil in the field. If the application rate exceeds the soil intake rate, the water will run off the field or relocate within the field resulting in over and under watered areas. Three different sprinkler systems for irrigation purpose are proposed in this paper. The three different systems are stating the configuration of the sprinklers as at between 2 rows but on height with 2 sprinklers, on plants at topmost position and on plants at topmost position but 2 sprinklers at position. The comparison based on the eleven points amongst the three configurations along with the traditional sprinkling system is made and further the most suitable configuration of sprinkler system is predicted.
Рembrolizumab as second line therapy for hepatocellular patient
Authors: Dzhanyan I. A. , Breder V. V. , Borisova O. I. , Laktionov K. K.
Published: December 2021

The optimal hepatocellular cancer (HCC) therapy remains a challenge. Due to checkpoint inhibitors patients with intolerance to the targeted therapy and or those with the impaired liver function can get an appropriate drug therapy. This clinical observation illustrates the long-term effect of pembrolizumab as the 2-line therapy in a patient diagnosed with. Sorafenib in standard doses as first line therapy led to severe toxicity and necessitated the withdrawal of therapy. Although subsequently the doses were reduced and concomitant medications used, sorafenib therapy was discontinued due to pronounced side effects typical of kinase inhibitors. From August 2017 to September 2019, as a part of a clinical study, the patient received 35 courses of immunotherapy with pembrolizumab 200 mg i.v. every 3 weeks, with satisfactory tolerance. The best response - partial tumor regression – was achieved at 84 weeks of therapy and continues to this day. Favorable toxicity profile makes checkpoints inhibitors a good treatment option in patients with impaired liver function (Child-Pugh 7–8 points) or with intolerable toxicity of kinase inhibitors.
As duas lógicas nucleares
Authors: Moura José , Dias Monteiro Alvaro
Published: December 2021

A partir dos anos 1980, o Brasil tomou diversas medidas políticas de construção da confiança na área nuclear, culminando com a adesão ao Tratado de Não Proliferação das Armas Nucleares. A partir daí, tornou- se um enérgico apoiador do desarmamento nos foros internacionais. Mesmo assim, como domina a tecnologia de enriquecimento de urânio, continuou se ressentindo de ações externas negativas, que têm retardado seus projetos. Isso ocorre porque, como essa tecnologia é dual, a lógica internacional, baseada na ameaça das armas nucleares e privilegiando a não proliferação, tem pontos de choque com a brasileira, baseada nos usos pacíficos da energia nuclear, mas privilegiando o desenvolvimento e a autonomia nacionais. A lógica internacional origina pressões transmitidas por formadores de opinião na mídia especializada, que estão aumentando com os avanços no desenvolvimento do submarino convencional de propulsão nuclear, o que exigirá, a médio prazo, negociações com a Agência Internacional de Energia Atômica, sobre os procedimentos de salvaguarda para seu combustível. Conclui-se que, como a tecnologia é dual, sempre haverá choque entre as duas lógicas, mas o Brasil tem condições de negociação apesar da oposição da lógica internacional porque o Tratado reconhece o direito inalienável ao desenvolvimento da tecnologia nuclear para fins pacíficos.
Classification of a cracked-rotor system during start-up using Deep learning based on convolutional neural networks
Authors: Rezazadeh Nima , Ashory Mohammad-Reza , Fallahy Shila
Published: December 2021

This article addresses an improvement of a classification procedure on cracked rotors through Deep learning based on convolutional neural networks (CNNs). At first, a cracked rotor-bearing system is modeled by the finite element method (FEM), then throughout its start-up, the related time-domain responses are calculated numerically. In the following, as a pre-processing stage, continuous wavelet transform (CWT) and Short-time Fourier transform (STFT) are applied on the three various health conditions, i.e. without crack, shallow-cracked, and relatively deep-cracked shafts. The plots of CWT’s coefficients and STFT’s in these various classes are used as the input dataset in Deep learning based on CNNs and the three classes are introduced as the output. AlexNet with 25 layers is employed as the network. The results of the testing phase demonstrated that not only this expanded method has a reasonable capacity in the classification of cracked and healthy rotors, but it also can classify cracked rotors with different crack depths with a negligible error.
PREÇOS DOS IMÓVEIS EM NATAL-RN: BOLHA E CONTANGO NO PERÍODO 2005-2010
Authors: Bezerra Márcia Maria de Oliveira , Correa André Luíz , Mendonça Ana Rosa Ribeiro de , Clementino Maria do Livramento Miranda
Published: December 2021

À luz da abordagem de Davidson, a dinâmica de preços dos imóveis em Natal comporta fenômenos que merecem ser tratados. No período 2005-2007, observa-se uma situação de backwardation, cuja intensidade fornece evidências suficientes da ocorrência de uma bolha imobiliária na cidade. Após 2008, é possível identificar uma situação de contango diferente, percepção esta reforçada pelo movimento dos outros indicadores considerados na pesquisa referentes à comparação entre a evolução do valor dos aluguéis e a trajetória dos preços dos imóveis  e à evolução do indicador de preço e custo da construção. Esse artigo explora a possibilidade do tipo de contango observado permitir que o tratamento de bolhas, sustentado na perspectiva teórica desenvolvida por Davidson, capte o ponto de inflexão desse fenômeno, ou seja, da possível passagem do movimento ascendente de preços em direção ao seu processo de arrefecimento.
POR DE TRÁS DE UMA CAPA - Por Vicente Martos e Vinicius Dantas
Authors: Martos Vicente
Published: December 2021

Isto Não É Uma Festa surge da implicação entre as pesquisas de mestrado: Pesquisa-Casa: Táticas analíticas sobre performances invisíveis (Vicente Martos, UFRN, 2019), e Política e estética do designer: Práticas de suspensão dos programas utilitários e a redistribuição da competência projetual (Vinicius Dantas, UFPE, 2018).
La Filmoteca Española, un recurso didáctico para la Historia del Cine y los historiadores de la Educación
Authors: Manso Valeriano Durán
Published: December 2021

Las filmotecas constituyen un espacio esencial para localizar, restaurar, conservar y difundir los archivos audiovisuales. Además, posibilitan su conocimiento y estudio a nivel técnico, narrativo y estético. Debido a su carácter testimonial y artístico, estos archivos poseen un notable valor en áreas tan vinculadas como la Comunicación, la Historia y la Educación. Mediante una metodología cualitativo-descriptiva, este estudio tiene como objetivos reflexionar sobre las funciones de estas instituciones, tomando como estudio de caso a la Filmoteca Española –creada en 1953 durante la dictadura franquista-, y abordar sus posibilidades didácticas para los historiadores. Así, se evidencia que el patrimonio de las filmotecas supone un material de primer orden para la enseñanza de las materias vinculadas a las tres citadas áreas.
Veinte años de dictadura
Authors: Amézola Gonzalo
Published: December 2021

Desde el inicio de la reforma educativa en Argentina, la enseñanza de la historia en la escuela secundaria  se centró en la época contemporánea.  En este contexto el objetivo de formar ciudadanos democráticos se concentró en  el estudio de la trágica experiencia vivida con  la última dictadura militar (1976 – 1983). Así fue como la dictadura se fue instalando  firmemente  como un tema escolar  en la enseñanza media desde 1993, lo que habilita algunas preguntas: ¿Cuáles son las características de esa enseñanza? ¿Qué se propone y qué logra efectivamente  la escuela con el estudio de la dictadura? Buscaremos indicios para esas cuestiones  en  el análisis de la normativa oficial, en la propuesta editorial  y los saberes  de los estudiantes a través de los datos relevados en casi mil encuestas.
Repeated Administration of Orexin into the Thalamic Paraventricular
Nucleus Inhibits the Development of Morphine-Induced Analgesia
Authors: Samani Fatemeh , Arami Masoumeh Kourosh
Published: December 2021

Background:

Hypothalamic neuropeptides, orexins, play pivotal roles in nociception
and pain modulation.

Objective:

In this study, we investigated the effect of the administration of orexin into the paraventricular
nucleus (PVT) on the development of morphine-induced analgesia in rats.

Methods:

Male Wistar rats weighing 250-300g received subcutaneous (s.c.) chronic morphine (6,
16, 26, 36, 46, 56 and 66 mg/kg, 2 ml/kg) at an interval of 24 hours for 7 days. Animals were divided
into two experimental groups in which the orexin (100 μM, 200 nl) and its vehicle were microinjected
into the PVT nucleus for 7 days before each morphine injection. Then, the formalin test was
performed for the assessment of pain-related behaviors.

Results:

The results demonstrated that the rats pretreated by intra-PVT orexin exhibited higher
pain-related behaviors than the morphine-treated group. The analgesic effects of morphine were significantly
lower in orexin plus morphine-treated rats than the vehicle plus morphine-treated ones.

Conclusion:

Our findings suggested that the animals receiving the prolonged intra-PVT application
of orexin before morphine injection demonstrated a significant increase in the development of
nociceptive behaviors in all phases. There fore, the present study highlighted a new area of the
brain involved in the effect of orexin on analgesia induced by morphine.
Indazole and its Derivatives in Cardiovascular Diseases: Overview,
Current Scenario, and Future Perspectives
Authors: Uppulapu Shravan Kumar , Alam Md. Jahangir , Kumar Santosh , Banerjee Sanjay Kumar
Published: December 2021

:

Indazoles are a class of heterocyclic compounds with a bicyclic ring structure composed of a pyrazole ring and a benzene ring. Indazole-containing compounds with various functional groups have important pharmacological activities and can be used as structural motifs in designing novel drug molecules. Some of the indazole-containing molecules are approved by FDA and are already in the market. However, very few drugs with indazole rings have been developed against cardiovascular diseases. This review aims to summarize the structural and pharmacological functions of indazole derivatives which have shown efficacy against cardiovascular pathologies in experimental settings.
Counterfeit? I don’t mind
Authors: Yulianti Ni Made Dhian Rani , Saputra A. A. Gd. Deni Windu
Published: December 2021

The purpose of this study was to determine how the influence of Fashion Consciousness, Subjective Norm, and Hedonic Shopping Motivation on Purchase Intention of counterfeit fashion products. This study used a quantitative approach that targets youth consumers in Denpasar City. Data was collected through an online questionnaire using a google form involving 100 respondents. The data were analyzed using SPSS software version 26.0. This research provides evidence that purchase intention is influenced by fashion consciousness and hedonic shopping motivation, while the subjective norm has no significant effect on the purchase intention of counterfeit fashion products. This research has implications for fashion product entrepreneurs, both original and counterfeit products, regarding the internal factors of consumers that influence purchase intentions on fashion products, especially counterfeit fashion products.
Improving the strategy to create a profitable and sustainable business in the era of economic competition in Indonesia
Authors: Dyanasari Dyanasari , Siswadi Bambang , Hindarti Sri , Askafi Eka , Mulyaningtiyas Ratna Dewi
Published: December 2021

This project aims to improve business strategies to increase profits and sustainability in the era of business competition. The data that we use to answer the discussion of this study is sourced from some literature published in several journals such as books, procedures at other times. We then analyzed the data using a phenomenological approach, a method for exploring the data and then analyzing it under an in-depth interpretation approach to the coding system and evaluating analysis to provide the data as findings to answer high-quality questions. The data search is carried out by procedures and electronically with a keyword system. Based on the existing data and the discussion, we can finally conclude that the results include strategies to increase profits and business continuity in this competitive era is the ability instead of moving a business to understand the business world, study business strategies, understand and know the business competition system and have extensive knowledge of business that is run in an era full of intense competition. Hopefully, these insights to be a good input material to support future studies.
Some notes on outro in Portuguese
Authors: Brugè Laura , Giusti Giuliana
Published: December 2021

This paper studies the syntactic behavior of outro(s) in Brazilian and European Portuguese. Starting from the syntax of its Italian counterpart un altro/(degli) altri, we argue that outro(s)in prenominal position is neither an adjective nor a determiner, but an existential quantifier and that the presence of the indefinite article, um outro/uns outros, gives rise to a complex existential quantifier, like the corresponding Italian form. We also argue that outro(s) and um outro/uns outros do not specialize for different interpretations since they both substantially show the same ambiguity (one/some more or a/some different one(s)) and behave in the same way in relation to possible semantic interpretations typical of existential quantifiers
A “língua desportuguesa”. Próclise no português angolano e no português moçambicano
Authors: Martins Ana Maria
Published: December 2021

The expansion of proclisis in contexts that typically exclude it in European Portuguese has been described as a syntactic feature that characterizes Angolan Portuguese. This article studies the presence of this feature in the literary language, based on a corpus of texts by Angolan and Mozambican authors, representing two generations: authors born in the colonial period (the Angolan Pepetela and the Mozambicans Mia Couto and Paulina Chiziane) and authors born after the independence of their countries (the Angolan Ondjaki and the Mozambican Lucílio Manjate). The study results show that proclisis has a stronger presence in the works of Angolan authors than Mozambican authors, suggesting that the shift towards the generalization of proclisis is more advanced, socially widespread and accepted in Angolan Portuguese than in Mozambican Portuguese, although it is visible in both. It is in non-finite domains that the contrast between the two African varieties is more evident. Not only is the frequency of proclisis to the infinitive higher in the Angolan Portuguese corpus, but only there is proclisis to the past participle attested. Comparing the two generations of writers, we see a significant rise of proclisis to the infinitive between Pepetela and Ondjaki and it is in Ondjaki’s works that proclisis to the past participle occurs. Regarding the Mozambican Portuguese corpus, however, there seems to be a regression in the advance of proclisis between Mia Couto and Manjate. A closer look at Rabhia, by Manjate (2017), suggests that young speakers with a high level of education may perceive the spread of proclisis as a socially marked feature.
Online Monitoring of Effluent Quality for Assessing the Effect of Wastewater Treatment Plant to Discharge into the Receiving Water: a review
Authors: Rizaluddin Andri Taufick , Hardiani Henggar
Published: December 2021

In general, industries that use water in their production process will produce wastewater which usually contains a lot of polluting contaminants. It will affects the surrounding environment by contaminating the water bodies, which will adversely affect the health life of all living beings. Pollution that occurs in the some rivers in Indonesia has begun to raise concern for Indonesian Goverment. Some of the river locations already have heavy poluted status. The pollution is mostly caused by industrial waste and domestic waste along the river. Treatment plants for wastewater effluents are mandatory for any industry which discharges their wastewater effluents into the environment. Information on monitoring the quality of industrial wastewater is very important to be perceived by examining changes in water quality condition that are getting better or worse. It is necessary to develop a system that monitors the condition of industrial wastewater. Industrial wastewater monitoring is a device system that collects real time data. Online monitoring technology is one part that plays an important role in supporting activities to control marine environmental pollution. Real‐time monitoring of wastewater quality remains an unresolved problem to the wastewater treatment industry. One of the problem in most industries in Indonesia is that the operational and performance of wastewater treatment plants (WWTP) are still not optimal, and need to be improved. The application of industrial technology concept 4.0 and automation systems in the industry is expected to improve the WWTP supervision process which has advantages such as reducing down time, reducing consumption of raw materials, reducing the energy used, increasing productivity, improving product quality and making efficient use of resources and processes, so as to reduce industrial operating costs.
Adoption Level of Good Aquaculture Practices in Brackish Water Pond Aquaculture, Pinrang Regency, South Sulawesi Province
Authors:   Research Institute for Coastal Aquaculture, Maros, Indonesia, Mustafa Akhmad , Athirah Admi , Ratnawati Erna , Asaf Ruzkiah , Tarunamulia Tarunamulia ,   Research Institute for Coastal Aquaculture, Maros, Indonesia
Published: December 2021

Pinrang Regency is a center of brackish water pond aquaculture production in South Sulawesi Province in which some of brackish water pond farmers in this regency have adopted Good Aquaculture Practices (GAqP). A study was conducted to determine GAqP adoption level, to identify GAqP aspects required to be improved, and to determine the category of GAqP adoption level as the first step to maximize the GAqP adoption level in the brackish water ponds. Primary data were obtained from 76 respondents consisted of pond farmers who already have adopted and or obtained GAqP certificates. On the basis of the adoption level, the adoption level classification is carried out into three categories, namely low adopters, medium adopters, and high adopters. The results showed that the highest GAqP adoption levels in brackish water ponds were in food security (89.41%) and technical aspects (78.57%). The lowest GAqP adoption levels were in management (8.71%) and environmental aspects (0%). It was also reported that the GAqP adoption level in brackish water ponds varied from 40.58 to 67.01% with an average of 42.86% and was categorized as moderate adopters. Based on this study, management and environmental aspects were found to be the aspects that need serious attention to increase the GAqP adoption level in the brackish water ponds.
Psychological Impact and Social Support Received during COVID-19 among Nursing Students
Authors: Hashim Noraini , Nor Ismail Nurul Laili , Anuar Umi Namirah , Suryanto Suryanto
Published: December 2021

Uncertainty of the COVID-19 outbreak impacts mental health mainly among university students. This research seeks to identify the psychological impact and social support received among nursing students in UiTM Puncak Alam during COVID-19. A cross-sectional study used Depression Anxiety Stress Scale (DASS-21) and the Impact on Social and Family Support questionnaire among 114 nursing students. Students' anxiety (2.10 ± 1.20) was higher than depression (1.50 ± 0.73). However, participants reported receiving substantial social support, especially from family members (1.30±0.46). In conclusion, half of the participants showed the psychological impact; however, there was an increase in social support during the COVID-19 outbreak.
Keywords: psychological impact; social support; nursing students; COVID-19
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3060
The Attitudes of Egyptian Web-Based Health Information Seekers Toward Health Information Provided Through the Internet: Qualitative Study
Authors: Ghweeba Mayada , Lindenmeyer Antje , Shishi Sobhi , Waheed Amani , Kofi Mostafa , Amer Shaymaa
Published: December 2021

Background

The internet has become an established source of health information for many Egyptian internet users. Understanding users’ attitudes toward the benefits and limitations of web-based health information will explain the influence of this information on users’ health-related behavior and decisions.

Objective

This qualitative study aims to understand the attitude of Egyptian internet users toward internet health information and to explore the impact of obtained health information on users’ behavior and on their physician-patient relationship.

Methods

For this qualitative study, semistructured interviews were conducted with a total of 49 participants (41/49, 84% Egyptian internet users and 8/49, 16% physicians) who participated in focus groups or individual interviews. We used a thematic analysis approach to explain and demonstrate participants’ views, thoughts, and experiences in using web-based health information.

Results

The internet has become an important source of health information in comparison with other health information sources and is the central theme that has emerged across the thematic analysis. The attitude toward the use of internet health was classified into three main themes: feeling toward web-based health information (with subthemes: favoring, disliking, neutral, or having ambivalence feelings), motivators to seek internet health information, and behavioral changes using internet health information (subthemes: confidence, satisfaction, and improved knowledge). Themes that emerged from physicians’ interviews included the accessibility of the internet health information, good communication, and coordination of care between patients and their physicians, and the active engagement of patients with their management plan.

Conclusions

The internet has become an essential source of health information for Egyptian adults. Internet health information can improve the patient-physician relationship, especially when users discuss the obtained health information with their physician. Internet health information provided seekers with social support and self-confidence when making health decisions.
Phân tích các yếu tố tác động đến hoạt động chuyển giao, ứng dụng, đổi mới công nghệ tại thành phố Cần Thơ
Authors: Nguyễn Thắng Lợi , Nguyễn Hồng Phúc , Nguyễn Chí Ngôn
Published: December 2021

Mục đích của bài báo là trình bày phân tích Mô hình cấu trúc diễn giải (Interpretive Structural Modeling-ISM) và phương pháp Phép nhân ma trận tác động chéo được áp dụng để phân loại (Cross-Impact Matrix Multiplication Applied to Classification-MICMAC) là một công cụ phân loại mức độ quan trọng cụ thể của các yếu tố và mối quan hệ thứ bậc giữa các yếu tố, giúp cho việc đề xuất các giải pháp thúc đẩy hoạt động chuyển giao, ứng dụng, đổi mới công nghệ tại thành phố Cần Thơ được chặt chẽ và đạt hiệu quả tốt hơn. Các yếu tố chính này bao gồm 04 nhóm yếu tố lớn chứa đựng 14 yếu tố phụ được xác định thông qua các kết quả khảo sát 217 doanh nghiệp trên địa bàn thành phố Cần Thơ và tham vấn nhiều chuyên gia về khoa học và công nghệ. Kết quả cho thấy các yếu tố trong cụm "Nhân tố định hướng", bao gồm Khả năng thông thạo công nghệ, Tính chất đặc thù doanh nghiệp và Chiến lược và chính sách của Chính phủ có tác động mạnh mẽ nhất đến hoạt động này.
Nghiên cứu thực trạng nguồn dữ liệu đầu vào phục vụ xây dựng cơ sở dữ liệu quy hoạch sử dụng đất thành phố Vũng Tàu, tỉnh Bà Rịa – Vũng Tàu
Authors: Trương Đỗ Thùy Linh
Published: December 2021

Cơ sở dữ liệu quy hoạch sử dụng đất có vai trò hỗ trợ đắc lực cho công tác quản lý và giám sát tình hình khai thác, sử dụng đất đai, đặc biệt là quá trình thực hiện các dự án đầu tư công tại các địa phương. Với nhiều phương pháp (như thu thập tài liệu và dữ liệu, phỏng vấn chuyên gia, kế thừa, thống kê, phân tích và tổng hợp, bản đồ và ứng dụng GIS...), cơ sở dữ liệu địa chính và các tài liệu, dữ liệu có liên quan đến quy hoạch và điều chỉnh quy hoạch sử dụng đất của thành phố Vũng Tàu được phân tích nhằm đánh giá thực trạng nguồn dữ liệu đầu vào phục vụ xây dựng cơ sở dữ liệu quy hoạch sử dụng đất trên địa bàn. Kết quả đạt được cho thấy nguồn dữ liệu đầu vào của địa phương chứa khá đầy đủ thông tin cần thiết, với độ tin cậy cao và cơ bản đáp ứng yêu cầu xây dựng cơ sở dữ liệu quy hoạch sử dụng đất theo quy chuẩn dữ liệu của ngành tại Thông tư số 75/2015/TT-BTNMT.
Đặc điểm và phương pháp chẩn đoán bệnh do Ehrlichia canis gây ra trên chó tại thành phố Rạch Giá, tỉnh Kiên Giang
Authors: Lê Tuyết Đang , Nguyễn Đình Chuẩn , Dương Anh Thư , Nguyễn Khánh Thuận , Lý Thị Liên Khai
Published: December 2021

Nghiên cứu được thực hiện nhằm xác định những đặc điểm và phương pháp chẩn đoán hiệu quả bệnh Ehrlichiosis do Ehrlichia canis (E. canis) gây ra trên chó. Tổng số 151 mẫu máu được thu thập từ những con chó nghi nhiễm E. canis. Mẫu máu từ chó nghi bệnh được chẩn đoán bằng kit E. canis-Ab, đồng thời được kiểm tra sự hiện diện của phôi dâu E. canis trên tế bào bạch cầu bằng phương pháp nhuộm tiêu bản máu và đếm số lượng tiểu cầu. Kết quả kiểm tra cho thấy có 103/151 (68,21%) mẫu dương tính với E. canis bằng kit E. canis-Ab. Tình trạng giảm tiểu cầu được ghi nhận ở 69/80 (86,25%) con chó dương tính với E. canis. Tỷ lệ chó nhiễm E. canis tại thành phố Rạch Giá không phụ thuộc vào giới tính, giống, tuổi, hình thức nuôi, và tính trạng lông; nhưng phụ thuộc vào tình trạng nhiễm ve. Chẩn đoán bệnh do E. canis cần phải kết hợp cả hai phương pháp kiểm tra nhanh bằng kit E. canis-Ab và nhuộm tiêu bản máu đối với tất cả những con chó có biểu hiện lâm sàng. Giảm tiểu cầu là dấu hiệu đặc trưng nhất giúp chẩn đoán xác định chó nhiễm E. canis.
Hoàn thiện quy trình tái sinh in vitro cho giống lúa Nàng Thơm Chợ Đào
Authors: Nguyễn Văn Mạnh , Đỗ Tiến Phát , Trần In Đô , Huỳnh Kỳ
Published: December 2021

Trong công tác chọn tạo giống cây trồng, chuyển gene là một trong những cách tiếp cận hiệu quả nhất vì đưa trực tiếp gene mục tiêu vào giống cây nghiên cứu. Cách tiếp cận này cần phải thông qua hệ thống nuôi cấy mô hoàn thiện. Một trong những trở ngại lớn nhất của nuôi cấy mô ở các giống lúa thuộc nhóm indica là quá trình chuyển hóa các mô sẹo thành phôi vô tính và có tỷ lệ tái sinh rất thấp. Chính vì vậy, nghiên cứu được tiến hành nhằm xây dựng và đánh giá hiệu quả quy trình tái sinh cho giống lúa Nàng Thơm Chợ Đào (NTCD) cũng như mở rộng ứng dụng cho các giống lúa khác ở vùng Đồng bằng sông Cửu Long. Trong nghiên cứu này, khả năng tạo mô sẹo trên môi trường N6D (N6+2,4D) với giống NTCD đạt hiệu quả từ 95 tới 97%. Môi trường phù hợp với giai đoạn phát sinh phôi soma và tái sinh chồi lần lượt là MS+NAA+kinetin và MS+B, với tỷ lệ tạo chồi đạt 31,01%. Tỷ lệ tạo cây hoàn chỉnh đạt 30,71%, cây tái sinh được chuyển thành công ra trồng và chăm sóc trong điều kiện vườn ươm. Kết quả này là cơ sở cho các nghiên cứu tiếp theo nhằm hoàn thiện quy trình tái sinh và ứng dụng trong việc chuyển gene vào giống lúa NTCD.
Các nhân tố ảnh hưởng đến sự hấp dẫn của điểm đến du lịch Phú Quốc, tỉnh Kiên Giang
Authors: Trương Trí Thông , Tô Diễm Phụng
Published: December 2021

Nghiên cứu các nhân tố ảnh hưởng đến sự hấp dẫn của điểm đến có ý nghĩa quan trọng đối với sự tồn tại và phát triển của điểm du lịch. Mục tiêu của nghiên cứu này tập trung xác định các nhân tố ảnh hưởng đến sự hấp dẫn của điểm đến du lịch Phú Quốc, tỉnh Kiên Giang. Kết quả nghiên cứu cho thấy có 11 nhân tố ảnh hưởng đến sự hấp dẫn của điểm đến du lịch Phú Quốc, tỉnh Kiên Giang: (1) Nguồn nhân lực, (2) Vệ sinh và không có tình trạng chèo kéo, (3) Giá cả, (4) Cơ sở vật chất kỹ thuật và quà lưu niệm, (5) Tài nguyên du lịch, (6) An toàn và an ninh, (7) Cơ sở hạ tầng, (8) Quảng bá và xúc tiến, (9) Các di tích và bãi biển, (10) Sự kiện, lễ hội và sinh thái, tự nhiên, và (11) Dịch vụ giải trí về đêm. Từ đó, một số khuyến nghị được đề xuất nhằm tăng sức hấp dẫn của điểm đến Phú Quốc hơn nữa trong thời gian tới.
Phân tích chuỗi giá trị lúa gạo chất lượng cao theo hướng gắn kết doanh nghiệp và hợp tác xã tại tỉnh An Giang
Authors: Khổng Tiến Dũng
Published: December 2021

Sản xuất lúa gạo chất lượng cao nhằm phát triển bền vững ngành hàng là hướng đi phù hợp với nhu cầu thị trường. Nghiên cứu này phân tích chuỗi giá trị (CGT) lúa gạo chất lượng cao theo cách tiếp cận của GTZ ValueLinks (2007) sử dụng số liệu thu thập trực tiếp từ 100 nông dân và 31 tác nhân tham gia CGT tại tỉnh An Giang. Kết quả nghiên cứu chỉ rõ CGT lúa gạo chất lượng cao hiện nay đã có một số cải thiện so với chuỗi truyền thống, trong đó số tác nhân tham gia vào chuỗi giảm, lợi nhuận của nông dân được tăng lên. Phân tích kinh tế chuỗi cho thấy các tác nhân trong chuỗi hiện có giá trị gia tăng khá cao, nhất là công ty lương thực. Đây là điểm quan trọng làm căn cứ thu hút doanh nghiệp tham gia liên kết với nông dân. Tuy nhiên, CGT này hiện còn gặp nhiều thách thức như tình trạng phá vỡ hợp đồng và rủi ro về chất lượng. Như vậy, để phát triển và hoàn thiện CGT lúa gạo chất lượng cao hiện nay cần phát triển và hoàn thiện hợp tác xã kiểu mới làm cầu nối giữa sản xuất và tiêu thụ. Bên cạnh đó, cần có sự tham gia của các tổ chức tín dụng để đảm bảo nguồn vốn sản xuất cho nông dân và vốn kinh doanh cho doanh nghiệp tham gia liên kết.
Lựa chọn mô hình sản xuất của hộ trồng lúa trong điều kiện xâm nhập mặn: Trường hợp Cà Mau và Sóc Trăng
Authors: Phan Đình Khôi , Huỳnh Việt Khải , Võ Thành Danh , Ngô Thị Thanh Trúc , Hà Tấn Linh , Phạm Thị Ngọc Hân
Published: December 2021

Diễn biến xâm nhập mặn có ảnh hưởng rất lớn đến hộ trồng lúa ở các tỉnh ven biển ở vùng Đồng bằng sông Cửu Long, bao gồm Cà Mau và Sóc Trăng. Bài viết này phân tích các yếu tố ảnh hưởng đến quyết định lựa chọn mô hình canh tác trên đất lúa trong điều kiện xâm nhập mặn dựa vào mô hình Ricardian. Kết quả chỉ ra rằng nhiều mô hình trồng lúa kết hợp như lúa cá, lúa tôm, và lúa màu được ghi nhận trên địa bàn của hai tỉnh bên cạnh mô hình chuyên canh cây lúa. Xu hướng chuyển đổi từ mô hình trồng lúa chuyên canh 2 vụ và 3 vụ sang mô hình lúa kết hợp trong điều kiện xâm nhập mặn được ghi nhận với tỉ lệ khá cao trên 50%. Kết quả nghiên cứu còn cho thấy các yếu tố ảnh hưởng đến quyết định lựa chọn giữa mô hình sản xuất lúa chuyên canh và mô hình lúa kết hợp của hộ trồng lúa ở Cà Mau và Sóc Trăng bao gồm: diện tích đất, vay vốn, địa bàn và xâm nhập mặn. Trong đó, xâm nhập mặn là yếu tố quan trọng nhất tác động tích cực trực tiếp đến quyết định lựa chọn mô hình sản xuất từ lúa chuyên canh sang lúa kết hợp. Kết quả này phù hợp với xu hướng chuyển dịch cơ cấu nông nghiệp của các tỉnh khác ở trong vùng.