bluuebunny/crossref_metadata_2025 huggingface dataset:
ИЗУЧЕНИЕ ВЛИЯНИЯ ДЕКСПАНТЕНОЛА НА МЕТАБОЛИЧЕСКИЙ ПРОФИЛЬ ПРИ СТРЕПТОЗОЦИНОВОМ ДИАБЕТЕ
Authors:   Воронежский государственный университет, КУЗНЕЦОВ А.Ю. , БУЗЛАМА А.В. , КРЫЛЬСКИЙ Е.Д. , ФИЛИН А.А. ,   Воронежский государственный медицинский университет им. Н.Н. Бурденко, ДОБА С.Х. ,   Университет Аль-Манара
Published: April 2024

Одним из перспективных объектов для разработки лекарственных препаратов, предназначенных для патогенетической фармакотерапии осложнений сахарного диабета 1 и 2 типа может являться декспантенол. Цель исследования - изучение влияния декспантенола на метаболический профиль при экспериментальном стрептозоциновом диабете в доклинических исследованиях на лабораторных животных. В доклинических исследованиях на белых крысах самцах (n=42, по 7 в каждой группе) на модели стрептозоцинового диабета установлено, что декспантенол в дозах 50, 100 и 200 мг/кг, перорально 1 раз в день 30 дней не вызывает значимых изменений в показателях, характеризующих функции почек и печени, но при этом обеспечивает тенденцию к нормализации показателей липидного профиля крови, а так же признаки умеренного противовоспалительно действия.
СПЕЦИФИЧЕСКИЕ ФЕРМЕНТНЫЕ БИОТЕСТ-СИСТЕМЫ ДЛЯ ОЦЕНКИ БИОЛОГИЧЕСКОЙ АКТИВНОСТИ ЛЕКАРСТВЕННЫХ РАСТИТЕЛЬНЫХ СРЕДСТВ
Authors:   Всероссийский научно-исследовательский институт лекарственных и ароматических растений, ЛУПАНОВА И.А. , МИЗИНА П.Г.
Published: April 2024

В настоящее время в медицине широко применяются лекарственные препараты растительного происхождения. Однако они отличаются сложным химическим составом, содержание отдельных компонентов может меняться в зависимости от погодных условий, мест произрастания, изменений состава почвы и т.д. Всё это указывает на необходимость контроля каждой партии лекарственного растительного сырья по химическому составу или целевой биологической активности. Контроль биологической активности чаще всего проводят с использованием лабораторных животных. Во всех странах мира такие эксперименты строго контролируются законами и могут проводиться только с их соблюдением. Основываясь на принципах «трех R» в ФГБНУ ВИЛАР разработан альтернативный метод с использованием специфических ферментных биотест-систем (СФБТС) in vitro на основе ключевых ферментов гомеостаза. Целью работы являлось экономическое обоснование возможности использования СФБТС в оценке биологической активности растительных лекарственных средств на примере четырех экстрактов красных листьев винограда культурного (Vitis vinifera L.) различных сортов. При оценке их венотропной активности с применением СФБТС in vitro по сравнению с методами in vivo сокращаются затраты: временные в 2 раза, финансовые в 2,8 раз, количество лабораторных животных в 4 раза.
Критический обзор концепции социального инвестирования
Authors: Миронова Анна
Published: April 2024

Статья посвящена критическому анализу концепции социального инвестирования как основы социальной политики. В рамках концепции социального инвестирования фокус внимания социальной политики меняется с «пассивной» защиты граждан от наступления различного рода рисков, связанных с возможностью сохранения позиций на рынке труда, на «активную» поддержку граждан, направленную на расширение их возможностей по интеграции на рынок труда. Согласно концепции социального инвестирования, социальная политика должна быть направлена на инвестирование в человеческий капитал, чтобы в последующем граждане могли максимально эффективно реализовать свой трудовой потенциал на рынке труда. С одной стороны, политика, основанная на концепции социального инвестирования, имеет неоспоримые преимущества. Так, высокая вовлечённость населения в трудовую деятельность является эффективным способом поддержания доходов и обеспечения социальной интеграции. Кроме этого, высокий уровень занятости населения сокращает потребность в государственных пособиях и способствует устойчивости государства всеобщего благосостояния. В то же время концепция социального инвестирования не лишена недостатков. Анализ имеющихся исследований, посвящённых политике социального инвестирования, позволил условно выделить четыре основных направления критики данной концепции: чрезмерное бремя индивидуальной ответственности; ограниченность эффективности инвестиций в человеческий капитал; ограничение применимости социальной политики, основанной на концепции социальных инвестиций; проблема социальной интеграции через рынок труда для нетрудоспособных граждан. Выделенные ограничения концепции социального инвестирования во многом связаны с сохраняющейся значимостью такого фактора, как принадлежности к социальному классу, в объяснении социального неравенства. Исследования показывают, что социальные риски, обуславливающие бедность, социально стратифицированы во всех государствах всеобщего благосостояния. Учитывая это, социальное инвестирование не следует рассматривать как исчерпывающую модель социальной политики. Социальная политика не должна ограничиваться только социальным инвестированием. Социальное инвестирование должно дополняться социальной защитой населения.
«Эмоциональная разметка» психотерапевтической культуры: императивы, идейные противоречия и линии анализа
Authors: Симонова Ольга
Published: April 2024

Статья посвящена эмоциональной стороне «психотерапевтической культуры», возникшей в западноевропейском мире в результате проникновения идей психотерапии во все сферы общества. Эта культура стремительно глобализируется и претендует на роль морального регулятора, когда жизненные события, отношения и социальные процессы интерпретируются через психологическую призму. В то же время научный подход ослабевает, принимая формы, далекие от профессиональной психологии и адаптированные для массовой культуры. Социологи исследуют причины распространения психотерапевтической культуры, отмечая ее амбивалентность и связь с поздним капитализмом, в частности неолиберализмом. Некоторые исследователи видят в ней этический потенциал освобождения, формирование автономного морального субъекта, стремящегося к новым формам солидарности на основе этики подлинности и заботы о себе. Другие придерживаются критического подхода, рассматривая психотерапевтическую культуру как эмоционально-­идеологический инструмент, выгодный элитам и формирующий образ «нарциссического» субъекта, морально нечувствительного и утрачивающего социальные связи, которым легко управлять. Целью статьи является осмысление различных подходов к анализу терапевтической культуры и рефлексия над ее амбивалентностью на основе выделенных эмоциональных идеалов или императивов, которые могут иметь неоднозначные социальные последствия и ослаблять интегративный и творческий потенциал данной культуры. Основной точкой противоречий является сочетание стремления к рациональному управлению эмоциями и культа подлинных спонтанных чувств. В статье анализируются и другие противоречия, например, между стремлением к интенсивной эмоциональной коммуникации и желанием личной автономии. Эмоциональная терапевтическая логика современного общества является противоречивой, а потому адаптивной и совместимой с другими идеологическими представлениями, допустимой в разных культурных контекстах, включая российский. Важно оценить потенциал и влияние психотерапевтической культуры в различных сферах социальной жизни, особенно в социальной политике, где противоречивый терапевтический эмоциональный стиль может затруднять осуществление социально-­политических программ.
Palpation and functional assessment of the palate in isolated soft palate defects
Authors: Szkiełkowska Agata , Krasnodębska Paulina , Miaśkiewicz Beata
Published: April 2024

Wprowadzenie

Wady rozszczepowe wargi i/lub podniebienia dotyczą 2–3 na 1000 żywo urodzonych dzieci w Polsce. Według danych europejskich izolowane wady podniebienia to niespełna 8% wszystkich wad rozszczepowych. Najczęściej poszukiwaną wadą ukrytą jest podśluzówkowy rozszczep podniebienia. Celem pracy jest przedstawienie algorytmu postępowania diagnostycznego zawierającego palpacyjną i funkcjonalną ocenę podniebienia.

Materiał i metody

Prezentowany w pracy algorytm diagnostyczny został oparty na otolaryngologiczno-foniatrycznym doświadczeniu klinicznym Instytutu Fizjologii i Patologii słuchu. Algorytm zawiera elementy oceny morfologiczno-czynnościowej aparatu artykulacyjnego w dysfunkcjach twarzowo-ustnych: ocenę podniebienia od strony jamy ustnej oraz od strony nosogardła.

Wyniki

Na podstawie algorytmu diagnostycznego omówione zostały praktyczne aspekty wykorzystania oceny funkcjonalnej podniebienia w kontekście ryzyka niewydolności podniebienno-gardłowej po zabiegach adenotomii czy tonsillotomii, a także
przygotowanie pacjenta z ryzykiem niewydolności podniebienno-gardłowej do operacji migdałków.

Wnioski

Przed każdą kwalifikacją do adenotomii/ tonsillotomii wskazana jest wnikliwa ocena morfologiczno-czynnościowa obwodowego narządu artykulacyjnego ze szczególnym uwzględnieniem podniebienia miękkiego i twardego. Indywidualne podejście diagnostyczne do każdego pacjenta z podejrzeniem izolowanej wady podniebienia zakłada współpracę otolaryngologa, audiologa, foniatry oraz logopedy.
Autoimmunity and The Role of T Cells in Parkinson’s Disease (PPMI Whole Blood T cells) v1
Authors: Sulzer David
Published: April 2024

This protocol details autoimmunity and the role of T cells in Parkinson’s Disease (PPMI Whole Blood T cells).
BIDMC-TMC Nuclei Isolation from Frozen Cervix for Single Cell RNA-Seq v1
Authors: G Martelotto Luciano , Arruda de Amaral Antonella , Kalavros Nikolaos , Vlachos Ioannis , Wang Shuoshuo
Published: April 2024

As a fibromuscular organ, human cervix samples are naturally resilient to withstand strains and deformation during pregnancy and birth. Due to its consistency and composition, dissociation and disrupting the cervix or other parts of uterus to extract nuclei is a challenging step for single cell applications. Here, we present a comparably simple and fast protocol for single nucleus RNA sequencing that has been developed at BIDMC TMC, Spatial Technologies Unit of the Beth Israel Deaconess Medical Center of HuBMAP Consortium in collaboration with Luciano Martelotto from the University of Adelaide. We optimized this protocol for human cervix and other uterine parts, but also tested it successfully for other tissue types very rich (90%) in fibrous connective tissues. Our protocol combines liquid nitrogen facilitated tissue disruption with the fixed RNA (flex) kit from 10x Genomics and generating high quality libraries for HuBMAP.
Self-made chrome alum gelatin coated slides v1
Authors: Fritzsche Sonja
Published: April 2024

This is step-wise protocol to coating microscopy slides with chrom alum gelatin for better tissue adherence.
Traditional Fishing Knowledge and Fishing Policy Analysis v1
Authors: Bloom Kai
Published: April 2024

Examine how traditional fishing knowledge is not being passed down to the new generations of fishermen in Mo'orea, French Polynesia, thus causing fishing policy to be simplified. Additionally, examine the effects that simplified policy has on fish populations and if it further perpetuates the loss of traditional fishing knowledge. We expect to observe a reduction in fish populations after the implementation of simpler fishing policies, and that such policy, along with modern fishing techniques, are leading to increased loss of traditional fishing knowledge.
Longitudinal TSPO PET imaging with [18F] DPA-714 in PPMI (PPMI DPA-714 PET Imaging) v1
Authors: Standaert David
Published: April 2024

This protocol details the Longitudinal TSPO PET imaging with [18F] DPA-714 in PPMI (PPMI DPA-714 PET Imaging).
Mitochondrial DNA base editing in HEK293T cells v1
Authors: Lake Nicole , Ma Kaiyue , Cohen Justin , Lek Monkol
Published: April 2024

This protocol is for the transfection of mitochondrial-targeted DddA-derived cytosine base editors (DdCBE), and their subsequent selection, in HEK293T cells. This uses a dual plasmid system, where a ‘left’ and ‘right’ DdCBE are needed for editing. Enrichment of cells with both DdCBE halves is achieved by separate drug selection for the left and right plasmids.
Moldability and Solvent Debinding of Hydroxyapatite Micro-Part Processed through Micro-Powder Injection Molding
Authors:   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, Basir Al , Muhamad Norhamidi ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, Mohd Nor Mohammad Fadhli Izuddin ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, Mohamed Muhammad ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, Jamadon Nashrah Hani ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia
Published: April 2024

The development of the micro-powder injection molding (µPIM) process from the powder injection molding (PIM) process has been prompted by the demand of the worldwide market to produce micro-sized components. The need for µPIM-processed components is currently rising across a range of industries, including automotive, aerospace, food, biomedical, electronics, and telecommunications. In the current research work, homogeneous HA feedstock with a powder loading of 57 vol.% was prepared by mixing HA powder particles with palm stearin and low-density polyethylene (LDPE) binders at a mixing temperature of 150 °C for 6 h. Defect-free injection molded or green micro-sized components of HA were produced by employing injection pressure, injection time, mold temperature, and melt temperature of 12 bar, 5 s, 110 °C, and 180 °C, respectively. When mold temperatures less than 110 °C were used, short shot defects were frequently observed in green specimens. After solvent debinding at 60 °C for 50 min, 82.2% of the palm stearin was removed from the green part. No difference in dimension between the solvent debound part and the green part was noticed. An open-pore structure developed in the solvent debound HA microcomponent is helpful for eliminating the insoluble LDPE binder during the thermal debinding phase.
Design of Intelligent Hybrid Energy Ambulatory Surgical Center Ship in Efficient Way
Authors:   Faculty of Ocean Engineering Technology, Hasan Tawheed ,   Universiti Malaysia Terengganu (UMT), Malaysia, Jamaludin Shahrizan ,   Faculty of Ocean Engineering Technology; Universiti Malaysia Terengganu (UMT), Malaysia, Wan Nik W.B. ,   Faculty of Maritime Studies and Marine Science; Universiti Malaysia Terengganu (UMT), Malaysia
Published: April 2024

An Ambulatory Surgical Center (ASC), also known as an outpatient surgery center, is a medical facility that provides same-day surgical procedures to patients who do not require an overnight stay in a hospital. ASCs are equipped with state-of-the-art medical equipment and staffed by highly trained healthcare professionals, including surgeons, anaesthesiologists and nurses. There are many areas along the river where people do not have easy access to any surgery. They have to go far to get this service, for which they do not even take the service. This research is for them. This research will ensure their basic medical services. The contribution of this research, this world-class surgical ship goes to ensure the basic medical needs of poor people in remote areas where good healthcare is not available. Another great contribution that will surprise the world is that no conventional fuel is needed to ensure this healthcare service. So undoubtedly this research has a great contribution in the global energy crisis. To ensure efficient ambulatory surgical center (ASC) ship, conducting site assessment, sizing the hybrid system appropriately, selecting the right components, improving hybrid energy system design, implement intelligent system is important. And these are the scope of our research. A detailed analysis of all possible aspects has shown that using intelligent hybrid energy ships instead of conventional ships improves the quality of service. Long lasting service is achieved with low energy consumption, sustainability and no pollution even without compromising performance. In this research details of ASC will be critically discussed.
Graphene-Based Materials for Energy Harvesting at Microwave Frequencies: A Comprehensive Review
Authors:   Department of Electrical and Electronics Engineering, School of Electrical and Artificial Intelligence, Xiamen University Malaysia, Sepang, Malaysia, Cheah Dennis Yang Shen , Kang Chia Chao ,   Department of Electrical and Electronics Engineering, School of Electrical and Artificial Intelligence, Xiamen University Malaysia, Sepang, Malaysia, Tan Jian Ding ,   Department of Electrical and Electronics Engineering, School of Electrical and Artificial Intelligence, Xiamen University Malaysia, Sepang, Malaysia, Ariannejad Mohammadmahdi ,   Department of Electrical and Electronics Engineering, School of Electrical and Artificial Intelligence, Xiamen University Malaysia, Sepang, Malaysia, Chang Clifford Choe Wei ,   Department of Electrical and Electronics Engineering, School of Electrical and Artificial Intelligence, Xiamen University Malaysia, Sepang, Malaysia
Published: April 2024

Harvesting energy from microwave frequency is one of the key areas of research in the past decade to provide an alternative power source for wireless devices and sensor networks. The increase in the employment of Internet of Things (IoT) devices as well as sensors in order to support technological advancement leads to an increase in the energy demand. This in turn leads to environmental pollution due to the large amount of batteries being disposed. As such, in order to support the current demand for clean and sustainable energy that can reduce environmental pollution, various approaches to reduce the usage of conventional batteries in these systems are being researched. One of the approaches is the usage of the antenna to harvest radio frequency energy. The appearance of graphenebased material further sparked the interest of researchers due to its exciting properties. Therefore, this paper aims to provide a comprehensive review on the advancement of the usage of graphene-based material in the field of harvesting ambient radio frequency energy. Graphene material is first introduced in order to understand its characteristics and properties as a replacement for the conventional copper material. Current state-of-the-art approaches on graphene-based radio frequency energy harvesting systems were then reviewed and compared. The future prospect of graphene-based material in energy harvesting systems was also presented and discussed, shedding light on the future potential areas for research and development.
The Study of Thermal Comfort in a Common Commercial Car Cabin: Looking at Malaysia’s Perspective
Authors:   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Mohd Sabri Mohd Anas , Jun Chan Zhao ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Khamis Nor Kamaliana ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Mat Tahir Mohd Faizal ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Wan Ghopa Wan Aizon ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Meor Ahmad Meor Iqram ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia
Published: April 2024

Assessing thermal comfort in vehicles poses unique challenges compared to buildings. The in-car environment is characterized by specific factors such as sunlight exposure, poor clothing insulation, non-uniform average radiant temperature, and limited time to establish comfort parameters. To address these challenges, this study aims to evaluate thermal comfort in different branded car cabins by analyzing temperature distribution, air velocity, relative humidity, and dew point temperature. A comprehensive review of literature was conducted, focusing on various aspects including airflow regimes, factors influencing thermal comfort, measuring instruments, and comfort indices. Understanding these factors is crucial for developing comprehensive methodologies to assess thermal comfort and indoor air quality in vehicle cabins. The results of the study indicate that MPV cars offer superior comfort levels within the optimal range of -1 to +1, surpassing sedans and compact cars. These findings are instrumental in guiding design and engineering decisions to improve passenger comfort in vehicles. Tailoring the design of different car types to meet the specific comfort requirements can lead to enhanced overall comfort and satisfaction. In conclusion, this study provides valuable insights into assessing thermal comfort and indoor air quality in vehicle cabins. By addressing the unique challenges posed by the in-car environment, it offers guidance for designing and engineering vehicles that prioritize passenger comfort and well-being.
Monitoring For Strain-Based Railway Structure Assessment Approach Using Optical Fibre Sensor
Authors:   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering and Built Environments, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia, Agos Mustaram Agus Danish Hakim , Meor Ahmad Meor Iqram ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering and Built Environments, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia, Suhaimi Nur Shufinah ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering and Built Environments, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia, Nuawi Mohd Zaki ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering and Built Environments, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia, Zohari Mohd Hafizi ,   Advanced Structural Integrity and Vibration Research (ASIVR), Faculty of Mechanical and Automotive Engineering Technology, Universiti Malaysia Pahang, 26600, Pekan, Pahang, Malaysia, Ariffin Ahmad Kamal ,   Department of Mechanical & Manufacturing Engineering, Faculty of Engineering and Built Environments, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia, Muhammad Abdullah Aidie Zeid ,   Rail Engineering Department, Track Network Maintenance Ampang Line, 5th Mile Jalan Ampang, 68000, Ampang, Selangor, Malaysia
Published: April 2024

Railway transportation is essential and continually evolving with new technologies to achieve high efficiency and passenger safety. Monitoring railways can be challenging, especially when dealing with delicate equipment. This study outlines a basic guideline and real-time monitoring process for railway tracks, serving as precautionary measures. The research employs Fiber Bragg Grating (FBG) sensors directly attached to the railway track’s web surface, which have the potential to cause failures. Before sensor installation, several critical steps were taken to ensure the fragile FBG sensors remained intact. These steps involved preparing sensor arrangements and positioning them before installation. Additionally, a calibration test for FBG is performed using the Universal Tensile Machine (UTM) with a mild steel sample, achieving a measurement of almost 1.2 picometers/micro-strain. As a result, a shift in wavelength was successfully measured and collected, enabling the calculation of strain-stress data for the rail structure during operation. The collected data exhibited no irregularities or anomalies data, indicating the success of the monitoring process. The data obtained from a well-prepared installation greatly differs from that of an underprepared one. This study underscores the necessity of thorough preparation when handling delicate equipment like FBG sensor. Therefore, the FBG sensor has the capability to measure the strain-stress behavior of rail structures, allowing for more accurate predictive assessments to prevent rail failures.
Characterization and antimicrobial Properties of Cotton Fabric Loaded with green Synthesized Silica Nanoparticles
Authors:   Department of Textile Engineering, NED University of Engineering and Technology, Karachi, 75270, Pakistan, Amir Muhammad , Ali Asghar Muhammad Sajid ,   Department of Materials Engineering, NED University of Engineering and Technology, Karachi, 75270, Pakistan, Nadir Ali Saeeda ,   Department of Chemistry, NED University of Engineering and Technology, Karachi, 75270, Pakistan
Published: April 2024

During the past decade, improvement in the functionality of textile materials has become an important research field due to their significant health and safety benefits. Here we report, simple and cost-effective green synthesis of silica nanoparticles from fibrous residue of sugarcane bagasse followed by investigating the applicability on cotton fabric. The characteristics of synthesized nanoparticles were determined by techniques including FTIR (exhibited characteristic peak at 791.01 attributed to vibration of Si-O and the absorption band at 1072.48 cm-1 owing to asymmetric vibration of Si-O-Si confirming the formation of SNPs), SEM (40±2nm), and XRD (Examined spectra with JCPDS 36-1451 indicate well-defined peaks of Silicon Oxide). Debye Scherrer equation was used to calculate the mean crystallite size (19.79 nm) of powder Silica NP sample at the full width half maximum (FWHM) of the diffraction peaks of 2Ɵ positions. Applicability of synthesized nanoparticles was determined by assessing thermal stability and antimicrobial property of treated and untreated cotton fabric. It was observed that silica nanoparticles coated fabric showed substantial thermal stability at 1 % Silica NPs comparatively treated with 2% and 3% silica NPs due to clustering phenomena. Antimicrobial property, confirmatory test as positive control of treated fabric shown substantial increased in antibacterial activity in solutions containing silica NPs as compared to the ethanol solution. Moreover, 76 green profiling score of synthesized method was evaluated by Analytical Eco-Scale tool.
Investigation of a Wheel Liquid Desiccant Cooling System Performance via ANSYS CFX
Authors:   Department of Mechanical Engineering and Manufacturing, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi Selangor, Malaysia, Mohd Sabri Mohd Anas , Qin Loh Chow ,   Department of Mechanical Engineering and Manufacturing, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi Selangor, Malaysia, Khamis Nor Kamaliana ,   Department of Mechanical Engineering and Manufacturing, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi Selangor, Malaysia, Meor Ahmad Meor Iqram ,   Department of Mechanical Engineering and Manufacturing, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi Selangor, Malaysia, Wan Ghopa Wan Aizon ,   Department of Mechanical Engineering and Manufacturing, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi Selangor, Malaysia
Published: April 2024

A liquid desiccant cooling system is an alternative air-conditioning system with significant energy-saving potential. This system is commonly used in the industrial sector, such as in dehumidifiers. The key component of the liquid desiccant cooling system is its dehumidification performance. Therefore, a study on a liquid desiccant dehumidifier has been conducted to predict its performance using computational fluid dynamics analysis. In these simulations, the effects of the temperature of the liquid desiccant and the velocity of air flow on the absorption process between the liquid desiccant and air were studied. The same applies to the velocity profile, which helps determine the airflow pattern within the dehumidifier. The model was constructed using ANSYS FLUENT and Autodesk Inventor. The model is the rotary desiccant wheel dehumidifier which was used to dehumidified the air.. ANSYS CFX was used for simulating the velocity profile to achieve the airflow pattern in the dehumidifier. The volume of fluid was selected as the multiphase method for the second simulation process. The temperature and mass fraction of water were monitored within the air during the counterflow simulation between the liquid desiccant and the air. The liquid desiccant chosen for this study was LiCl. The simulations were conducted at specific air velocities, and the behavior within the dehumidifier was observed. The analysis results revealed that the air entering the rotary desiccant wheel dehumidifier experienced a drop in velocity after passing through the desiccant wheel in the middle. Additionally, turbulence occurred after the air passed through the wheel and the dehumidifier’s wall. Based on these findings, the design of an optimal dehumidifier and the selection of an appropriate air velocity for cooling can be carried out.
Kesan Penambahan Fukoidan Terhadap Kualiti Penyimpanan Kombucha
Authors: Aziz Nurul Shahirah , Abd Aziz Nur Syafiqa , Lim Seng Joe , Sofian-Seng Noor-Soffalina , Wan Mustapha Wan Aida , Abdul Rahman Hafeedza , Mohd Razali Noorul Syuhada
Published: April 2024

Kombucha ialah minuman berasid yang dihasilkan daripada teh manis setelah penapaian menggunakan kultur simbiotik bakteria dan yis (SCOBY). Ekstrak fukoidan daripada rumpai laut menjadi bahan berfungsi tinggi antioksidan yang boleh meningkatkan kualiti penyimpanan kombucha. Objektif kajian ialah untuk mengukur kesan penambahan fukoidan pada kepekatan berbeza (0.0, 0.25, 0.50, 0.75, 1.0 mg/mL) terhadap kualiti fizikokimia kombucha seperti warna, nilai TSS, nilai TA, nilai pH, flavonoid serta antioksida (TPC, DPPH dan FRAP) yang disimpan pada suhu 4 °C selama 14 hari. Kombucha yang diperkuat dengan fukoidan disediakan menggunakan teh bergula (150 g sukrosa/L larutan teh) yang ditapai dengan 150 mL kultur pemula SCOBY pada suhu 28 °C selama 7 hari. Selepas proses penapaian selesai, kombucha disimpan pada suhu 4 °C untuk pencirian fizikokimia dan bioaktiviti pada hari 0, 7 dan 14. Hasil kajian mendapati penambahan fukoidan mempengaruhi nilai warna a* dan b* (p<0.05) namun tidak merubah kecerahan (L*), menurunkan nilai TSS dan nilai TA (p<0.05), meningkatkan nilai pH (> pH 2.5) serta merendahkan kandungan alkohol (< 0.5%). Manakala, kesan bioaktiviti kombucha dengan kepekatan fukoidan 1.00 mg/mL mencatatkan peningkatan TFC: 5.78 ± 0.19 mg QUE/mL (p<0.05), TPC: 0.47 ± 0.01 mg GAE/mL (p<0.05) dan FRAP 390.43 ± 0.03 mg AAE/mL (p<0.05) lebih tinggi selepas 14 hari berbanding sampel kawalan. Fukoidan serendah 0.25 mg/mL meningkatkan peratusan DPPH seiring peningkatan kepekatan (p<0.05). Ciri fizikokimia, bioaktiviti serta antioksidan minuman kombucha telah meningkat setelah ditambah dengan 1.0 mg/mL fukoidan selepas 14 hari penyimpanan.
A Vortex-Assisted Deep Eutectic Solvent for Parabens Extraction in Cosmetic Samples Coupled with High Performance Liquid Chromatography
Authors: Muhamad Yusri Nurin Farawani Binti , Md Saleh Noorashikin Binti , Elan Solan Tanusha Devi , Mat Salleh Muhammad Zulhaziman
Published: April 2024

Parabens, commonly used preservatives in food, cosmetics, and pharmaceutical items, inhibit harmful germ growth. Deep Eutectic Solvents (DES) are intriguing for analyte extraction due to superior properties formed through hydrogen bond acceptors and donor interactions. However, the studies on the optimal DES-based extraction conditions for paraben-containing cosmetics and the accuracy of 'paraben-free' labels are limited. The most effective DES (DL-Menthol and decanoic acid, 1:2 molar ratio) was applied to cosmetic samples after heating at 80 °C following optimization parameters. FTIR study confirmed hydrogen bonds in DES samples. Both paraben-containing and paraben-free samples showed methyl, ethyl, and propyl paraben peaks from the HPLC analysis. Cosmetic sample paraben concentrations ranged from 0.53 mg/L to 26.08 mg/L (non-spiked). LOD and LOQ were 0.24 mg/L-1.62 mg/L, 0.73 mg/L, and 4.8 mg/L, respectively. Goals were met by establishing a paraben extraction method using DES and investigating paraben quantities in cosmetics.
Evolusi Pancaran Sinar-X Sagittarius A* antara Tahun 1999 sehingga 2019 Berdasarkan Pemerhatian Observatori Sinar-X Chandra
Authors: Azizan Aimi , Abdul Hamid Muhammad Ezzat , Annuar Adlyka
Published: April 2024

Kertas ini membentangkan pemerhatian Observatori Sinar-X Chandra terhadap Sagittarius A* (Sgr A*) yang diambil sepanjang dua dekad pertama operasi observatori tersebut antara tahun 1999 dan 2019. Spektrum sinar-X bagi 143 pemerhatian dianalisis untuk mengkaji evolusi sinar-X Sgr A* sepanjang 20 tahun melalui ciri utamanya, iaitu kecerahan (luminositi), ketumpatan gas dan debu (NH) dan indeks foton (Γ). Secara amnya, Sgr A* berada dalam keadaan stabil sepanjang tempoh pemerhatian, dengan purata luminositi sinar-X intrinsik dalam julat tenaga 2 – 8 keV iaitu, L2-8 keV,int,kes = (3.69 ± 4.25) ×1033 erg s–1. Nilai ini tekal dengan purata luminositi sinar-X cerapan dalam jangka masa yang sama, L2-8 keV,cer,kes = (2.24 ± 2.12) ×1033 erg s–1. Walau bagaimanapun, terdapat tujuh pemerhatian (~5%) yang mempunyai luminositi intrinsik melebihi nilai purata yang dianggarkan. Nilai NH dan Γ yang diukur bagi kesemua pemerhatian dilihat tekal sepanjang tempoh kajian dengan nilai purata, NH ukur = 0.90 ± 0.35 ×1023 cm–2 dan Γ ukur = 1.90 ± 0.68. Ini mencadangkan bahawa kebolehubahan dalam luminositi yang diperhatikan bukan disebabkan oleh pengaburan atau perubahan besar dalam kadar penokokan. Selain itu, kajian ini juga mengukur luminositi sinar-X tertinggi bagi Sgr A*, L2-8 keV,int = 3.84 ± 4.25 0.37 ×1034 erg s–1, yang berlaku pada 14 September 2013. Keputusan ini sejajar dengan suar yang paling terang pernah dikesan dalam kajian terdahulu. Ini diikuti dengan pemerhatian pada 19 Ogos 2019 dengan luminositi, L2-8 keV,int = 2.40 ± 0.52 0.36 ×1034 erg s–1. Kajian ini memberikan gambaran menyeluruh terhadap evolusi pancaran Sgr A* selama dua dekad pertama pengoperasian Chandra dan meningkatkan lagi pemahaman terhadap lohong hitam ini.
Housing Norms and Standards: The Design of Everyday Life
Authors: Jacoby Sam , Özer Seyithan
Published: April 2024

This editorial introduces the articles in this thematic issue, which bridge the gap between technical housing standards, design practices, and socio-cultural norms.
Quotations from D.B. Elkonin's Speech at the Meeting of the Academic Council of the Psychological Institute Dedicated to His 80th Anniversary
Authors: Elkonin D.B.
Published: April 2024

Quotations from D.B. Elkonin`s speech at the meeting of the Academic Council
Round Table "From the Psychology of Play to the Psychology of Learning: the Scientific School of D.B. and B.D. Elkonin
Authors: Kudryavtsev V.T.
Published: April 2024

Review of the round table on the topic "From the psychology of play to the psychology of teaching: the scientific school of D.B. and B.D. Elkonin", dedicated to the 120th anniversary of the birth of D.B. Elkonin, which took place on February 29, 2024 at the Moscow State Psychological and Pedagogical University. Pedagogical University. The state of the Elkonin scientific school is reflected both from a historical point of view and from the point of view of new approaches developed within its framework recently, and related research perspectives. The participants agreed that the scientific school of D.B. Elkonin - B.D. Elkonin sets a fundamental trend in the development of cultural and historical psychology in the first third of the XXI century.
Evald Ilyenkov on Freedom of Will
Authors: Maidansky A.D.
Published: April 2024

Evald Ilyenkov’s works explores the issue of free will within the framework of activity theory. According to him, the concept of freedom is linked to the general activity of living beings in the external world and to the purposeful nature of this activity. Human freedom, or the ‘freedom of the will’, is treated as acting in accordance with the “purpose of the species”, that is, the interests of human society. The will is a psychological function that subordinates an individual’s activity to the goals and norms of social life. Alternative doctrines postulate free will as an immediate “fact of consciousness”, discovered through introspection and underlying human activity. This is where traditional empirical psychology intersects with the physiological doctrine of the unconditional reflex of freedom. Ilyenkov regards such a conception of free will as a “psychological illusion” and examines the implications of this illusion in the classic experiments of academician Ivan Pavlov. The article offers a cultural-historical perspective on the development of the human mind as a process of increasing free will: the emancipation of mental activity from the captivity of natural affects through the use of cultural tools and man’s rational understanding of the world and himself.
A Human Through the Prism of Jointness. The Possibility of a General Psychology
Authors: Novichkova A.V.
Published: April 2024

The paper raises the question of the possibility of creating a general psychological field of research. The condition for the beginning of such research is a sufficiently complete general model of psychological phe­nomena. The assumption is made that the work of identifying suitable psychological universals has already been done as a part of cultural-historical psychology. We summarised the investigations, starting with L.S. Vygotsky’s idea of a psychological “unit”. With the help of some modern theories, the assumption is substantiated that joint meaning field is the essence of the human in man. The history of the “integral unit of the human lifeworld” construction in the F.E. Vasilyuk’s school and its transformation into a scheme of jointness is described. By analysing F.E. Vasilyuk's notion of “experiencing”, the activity-dialogical model of jointness is extrapolated and filled with “meaning”. This model is proposed as a suitable tool for generalis­ing psychological knowledge. An assumption is made about resonance as a fundamental mechanism of joint­ness formation. In this paper we describe the properties of the prism of jointness and question its sufficiency for the beginning of general psychological research.
The Life and Vegetating
Authors: Suvorov A.V.
Published: April 2024

For several years, A.V. Suvorov has been doing mailing lists for like-minded colleagues and friends. Each of the letters is a scientific and journalistic text on philosophical, psychological, pedagogical, and life topics. A.V. Suvorov signed his letters "Hedgehog" - that's how he called himself, meaning not only prickly, but also the desire to isolate himself for a while, shrink, withdraw into himself from the world, so that he could then turn to him with something important. We bring to your attention his latest essay, or rather, the last revision of the text that he wrote almost a quarter of a century ago. The author reflects on how to overcome universal, collective and individual, personal nonsense as a way of existence. In his opinion, didactics is intended to provide a means of understanding existence.
La romanización de la actual provincia de Toledo: los municipia de Toletum, Consabura y Caesarobriga
Authors: Patiño Amor Ángel
Published: April 2024

La conquista romana de la Península Ibérica supuso la necesidad de incorporar un sistema que facilitase su romanización y la administración del territorio. En la actual provincia de Toledo destacaron Toletum, Caesarobriga y Consabura, que adquirieron el carácter de municipium. En esta investigación se analizan diversos vestigios de la romanización de esta región, así como su configuración municipal.
Opus Facere: una aportación de las fuentes jurídicas romanas en la sistematización de las obligaciones
Authors: Polo Arévalo Eva María
Published: April 2024

Este trabajo estudia la trascendencia que tuvo la acogida del binomio “medios-resultado” en el ámbito de las obligaciones y contratos en los instrumentos de armonización del Derecho europeo y su incorporación en la Doctrina civilista y Jurisprudencia española como intento para clarificar la regulación del arrendamiento de obras y servicios presente en el Código Civil. Se analiza también el progresivo abandono que esta distinción ha tenido en las propuestas de modernización y reforma del Código Civil publicadas en España. Se estudian finalmente las fuentes de Derecho romano en las que están presentes las nociones de opus y opus facere en el marco de las obligaciones nacidas en la locatio-conductio y regidas por los principios de buena fe y deber general de lealtad de las partes, ofreciendo una visión retrospectiva que pueda ayudar en la regulación futura de esta materia.
Tácito y la fidelidad a las fuentes jurídicas primarias
Authors: Posadas Sánchez Juan Luis
Published: April 2024

En este artículo reivindicamos la profundidad de los conocimientos jurídicos y legales de Tácito para poner en valor su obra como fuente de conocimiento jurídico. En concreto, analizamos la fidelidad de Tácito a las fuentes primarias del Derecho romano, por medio de un análisis comparativo entre las leyes conservadas epigráficamente (las Tabulae) y las menciones a dichas leyes que encontramos en los Anales de nuestro autor.

La conclusión es que Tácito conocía los textos legales, y los utilizaba como fuentes primarias para su obra histórica, pero los resumía, seleccionaba y adaptaba para usarlos con un fin historiográfico y político. En síntesis, podemos afirmar que las menciones de Tácito a temática jurídica pueden considerarse como fuentes secundarias para el conocimiento del Derecho romano.
Distorsiones del derecho de la persona en el siglo XXI
Authors: Rogel Vide Carlos
Published: April 2024

Capacidad, discapacidad e incapacidad. Animales, cosas y máquinas como pretendidos titulares de derechos. Los riesgos del metaverso. La dignidad de la persona como clave de nuestro sistema jurídico.
La cuestura a lo largo de la historia: de su incierto origen a su esplendor
Authors: Roncero Núñez Javier
Published: April 2024

La cuestura es quizá la menos estudiada de las magistraturas. Relegado al ámbito de los magistrados menores, su papel ha sido tradicionalmente pasado por alto a favor de otros puestos más interesantes como el pretor o el tribuno de la plebe. A pesar de ello, el cuestor resulta sumamente interesante, no solo por la prolongada existencia a lo largo del tiempo (desde la Monarquía hasta el Principado), sino también por la gran variedad de competencias que fueron adquiriendo durante todo este periodo, llegando a ocupar múltiples responsabilidades en diferentes niveles territoriales. Su incierto origen, el aumento de sus tareas y su eventual desaparición ocupan el contenido de la presente investigación.
Laudatio al Prof. Dr. Justo García Sánchez
Authors: Torrent Ruiz Armando
Published: April 2024

Laudation in memoriam al Prof. Justo García Sánchez
Memoria de publicaciones de Derecho Romano año 2023
Authors: Duplá Marín Maria Teresa , Panero Oria Patricia
Published: April 2024

La Memoria de Publicaciones de Derecho Romano año 2023 que presentamos tiene como objetivo principal la recopilación y presentación de los trabajos de investigación de Derecho Romano publicados a lo largo del año 2023, y cuyos autores han tenido a bien trasladarnos a tal fin.
Acute appendicitis in adults: only clinical and laboratory diagnostics, only imaging, or both?
Authors: Ryazanov Vladimir V. , Sadykova Gul’naz K. , Trufanov Gennadiy E. , Zheleznyak Igor’ S. , Bagnenko Sergey S. , Ipatov Victor V. , Voronkov Leonid V. , Romanov Gennadiy G. , Bagaturia Georgiy O.
Published: April 2024

The presented article is devoted to the discussion of the necessity and expediency of using medical visualization diagnostics — radiological imaging — of acute appendicitis as an independent or complex approach in combination with clinical and laboratory data. Until now, the clinical diagnosis of each individual case of acute appendicitis is complicated, and its formulation requires combining clinical, laboratory and imaging data, since it includes a wide range of differential diagnoses depending on age and gender. The literature provides data that the frequency of negative appendectomies based on the results of a clinical examination can be up to 28.2%. Radiological imaging is used as an adjunct to clinical diagnostics using ultrasound examination, computed tomography and magnetic resonance imaging, but the role of the latter is limited by the duration of the study, increased cost, unavailability around the clock, as well as the presence of absolute contraindications. Sonography and computed tomography in diagnostics have a number of advantages and disadvantages, and the question of choosing a specific method still causes scientific controversy. We also provide illustrative clinical examples demonstrating echographic and computed tomographic imaging manifestations of acute appendicitis, as well as discuss visualization signs. For a patient with suspected acute appendicitis, in order to increase the accuracy of diagnosis, reduce complications or the need of undergoing unnecessary diagnostic and therapeutic procedures, a multidisciplinary and multimodal approach is necessary, taking into account age, gender and constitution, however, the question of choosing the optimal method of medical imaging in the diagnosis of acute appendicitis between ultrasound and computed tomography remains debatable.
To the 100th anniversary of professor Viktor Pavlovich Baskakov
Authors: Bezmenko Aleksandr A. , Kira Evgeny F. , Bezhenar Vitaly F. , Abashin Victor G. , Beskrovny Sergey V. , Gaivoronskikh Dmitry I. , Zakharov Igor’ S. , Shkarupa Olga A.
Published: April 2024

The article describes the main milestones in the labor, scientific and pedagogical activities of Professor Viktor Pavlovich Baskakov, born on November 28, 1923. After graduating from the Military Medical Academy and defending his dissertation for the degree of Candidate of Medical Sciences in 1950, he was hired as a teacher in the Department of Obstetrics and Gynecology, in 1958 he was appointed to the position of associate professor, in 1970 he received the title of professor, after which in 1974 he became head of department, where he worked until 1984. Viktor P. Baskakov was the first in the country to begin studying endometrioid disease. Three of his monographs are devoted to this complex pathology: “Endometriosis” (1966), “Clinic and treatment of endometriosis” (1979, 1990) and “Endometrioid disease” (2002). In 1968, based on the published monograph “Endometriosis” by V.P. Baskakov was awarded the academic degree of Doctor of Medical Sciences without defending a dissertation. For many years, Viktor Pavlovich was a member of the presidium of the Leningrad Obstetrics and Gynecology Society, a member of dissertation councils, and the editorial board of the Journal of Obstetrics and Women’s Diseases. He was awarded the Order of the Red Star and medals, including the medal “For Military Merit” and the medal “For Victory over Germany in the Great Patriotic War of 1941–1945.” Professor Viktor Pavlovich Baskakov remained in the memory of his contemporaries as a talented scientist, teacher, and surgeon. It was difficult to find a person more concerned about the problems of others. Students remember him with a smile and great warmth.