bluuebunny/crossref_metadata_2025 huggingface dataset:
Level of Patient’s satisfaction with Online Psychiatric Outdoor services
Authors: Jilani Abdul Qadir , Khan Arish , Saloni Saloni , Kumar Seshan , Singh Jai , Verma Kushagra , Siddique Aleem , Sinha Reema
Published: September 2022

Purpose: During the ongoing COVID-19 global pandemic, there have been treatment gaps for common physical and mental disorders due to vast reasons like lockdowns, poor convenience, fear of getting COVID infection, and economic restraints. Hence, to reduce the treatment gap and, also to limit exposure to COVID-19 infections, telemedicine in the form of telephonic and internet consultations has been increasingly adopted worldwide. Our centre also started telepsychiatry to cater for the needs of patients with pre-existing mental health disorders to ensure regular follow-up and compliance with prescriptions. The study aimed to assess the level of patient satisfaction through online psychiatric services (Telepsychiatry).
Methods: Ethical clearance for the present study was granted by the research cell of the study centre. The sample consisted of 100 patients with pre-existing mental health disorders. This was a single-point cross-sectional study for 6 months. Hospital Information system (HIS) software, which is used to manage the patient's appointment schedule, relevant clinical and lab details along with follow-up prescriptions was used to follow the selected patients for study purposes. This software also provides a digital platform for video calls for online consultation. Client Satisfaction Questionnaires-8 (CSQ-8) were applied to collect patient data for analysis.
Result: The mean total CSQ-8 score of the study sample was 21.01±5.80 (8-32), which indicates a low to moderate level of satisfaction with online psychiatric services. Most patients (45%) reported low satisfaction levels followed by 37% of the patients who reported moderate levels of satisfaction. Only 18% of the patients reported higher satisfaction with online psychiatric services.
Conclusion: Despite the psychiatrist's ability to deliver adequate professional advice and psychoeducation through online psychiatric services, the patient’s level of satisfaction was moderate to low. This suggests a need to design standard protocols and guidelines for consultation through online psychiatric services to enhance the patient’s level of satisfaction.
Simulated nitrogen deposition and precipitation events alter microbial carbon cycling during early stages of litter decomposition
Authors: Kroeger Marie E. , Wang Renée Z. , Suazo Dennis , Yoshida Thomas , Albright Michaeline B.N. , Dunbar John
Published: September 2022

Plant litter decomposition is a major nutrient input to terrestrial ecosystems that is primarily driven by microorganisms. Litter decomposition results in a flow of dissolved organic carbon (DOC) that links above-ground decomposition to below-ground microbial processes. Litter decomposition is expected to be altered by human-induced global disturbances—specifically nitrogen deposition and altered intensity and frequency of precipitation events—but little is known about impacts on the mobile pool of DOC. This study investigated the effect of simulated nitrogen deposition and increased precipitation events on microbially-driven carbon flow during short-term litter decomposition using a ‘common garden’ experimental design with microcosms containing sterile sand and blue grama grass litter inoculated with different soil microbial communities. Respiration (CO2) was measured throughout the experiment while microbial biomass carbon and nitrogen were quantified at the end. Overall, nitrogen deposition decoupled CO2 and DOC during short-term litter decomposition with respiration increasing and no affect on DOC concentration. Moreover, nitrogen deposition increased microbial biomass and had no effect on carbon use efficiency (CUE). Simulated precipitation events significantly increased DOC concentrations, decreased CUE, increased the microbial metabolic quotient (qCO2), and greatly altered microbial composition and diversity. These findings highlight the complex interactions and responses of surface litter decomposers to the combined effects of climate change and supports the need for more research into how varying microbiomes will respond to different global change scenarios. Furthermore, this study clearly indicates that any increases in soil carbon sequestration from nitrogen deposition are unlikely to arise from a larger supply of DOC.
Characteristics of subscapularis muscle strain in professional baseball players: A case series
Authors: Komatsu Shuro , Kaneko Hironori , Nagashima Masaki
Published: September 2022

Background
Subscapularis muscle strains can develop in professional baseball players, rendering the players unable to continue playing for a certain period. However, the characteristics of this injury are not well known. The purpose of the present study was to investigate the details of the injury and the post injury course of subscapularis muscle strain in professional baseball players.
Methods
Of 191 players (83 fielders and 108 pitchers) who were members of a single Japanese professional baseball team between January 2013 and August 2022, 8 players (4.2%) had subscapularis muscle strain and were enrolled in this study. The diagnosis of muscle strain was made on the basis of shoulder pain and magnetic resonance imaging findings. The incidence of subscapularis muscle strain, the details of the site of the injury, and the time to return to play were examined.
Results
Subscapularis muscle strain occurred in 3 (3.6%) of 83 fielders and 5 (4.6%) of 108 pitchers, with no significant difference between fielders and pitchers. All players had injuries on the dominant side. Most injuries were located at the myotendinous junction and in the inferior half of the subscapularis muscle. The mean time to return to play was 55.3 ± 40.0 (range, 7-120) days. At a mean 21.0 months after the injury, there were no re-injured players.
Conclusions
Baseball players who have shoulder pain should be regarded as having possible subscapularis muscle strain, and proactive examination should be considered.
Trial registrations:
Not applicable
Spider mites avoid caterpillar traces to prevent intraguild predation
Authors: Kinto Shiori , Akino Toshiharu , Yano Shuichi
Published: September 2022

The phytophagous spider mites Tetranychus kanzawai and Tetranychus urticae can be as small as <0.5 mm; thus, they are often incidentally consumed along with food plant leaves by voracious lepidopteran larvae (hereafter, ‘caterpillars’). Therefore, the ability to avoid such intraguild predation should confer a selective advantage to mites. We experimentally demonstrated that adult females of both mite species avoided settling on food plant leaves with traces of all tested caterpillar species (Bombyx mori, Papilio xuthus, Spodoptera litura and Theretra oldenlandiae). We examined additional interactions using B. mori and T. kanzawai and found that B. mori trace avoidance by T. kanzawailasted for more than 48 h. Tetranychus kanzawai also avoided B. moritraces on plant stems, along which mites access leaves. Moreover, T. kanzawai avoided acetone extracts of B. mori traces applied to filter paper, indicating that chemical substances of caterpillar traces are responsible for the avoidance. This study is the first demonstration of a repellent effect of herbivore trace chemicals on heterospecific herbivores. Although spider mites have developed resistance against many synthetic pesticides, these results predict that natural compounds simulating caterpillar traces may repel spider mites from agricultural crops.
Human Monitoring Scanner Using GAIT
Authors: Macwan Kiran , Shah Harshal
Published: September 2022

Biometric system is useful to identify person. Biometric systems are rising and generally used technology. Because of this generalization today many protected systems are taking advantage of biometric systems. And one of these newest research areas of biometric systems is gait analysis systems. Numerous locations, including banks, airports, courtrooms for criminal proceedings, and security reasons, require the biometric technology. We can recognize a person by their fingerprints, handprints, eyes (retina), and face with the use of a biometric system . The issue of walking behavior is addressed through the use of gait technology. In security and video surveillance applications, gait identification is crucial. A person's lack of walking style may be resolved by reorganizing the gait. Gait biometric skill recognizes a individual by the walking pattern. Gait study investigates human body parts to find personal features for human recognition. Gait technology recognizes person walking pattern for individual detection. When person identification ratio matches up to 60% to 70% in order to that here Re-identification is solution. Several studies on this study area are examined during the survey.
Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration
Authors: Yang Zhujun , Li Xuejian , Gan Xueqi , Wei Mengying , Wang Chunbao , Yang Guodong , Zhao Yimin , Zhu Zhuoli , Wang Zhongshan
Published: September 2022

Background

Sustained release of bioactive BMP2 (bone morphogenetic protein-2) is badly needed for bone regeneration, while the intrinsic short half-life of BMP2 at protein level cann’t meet the clinical need. In this study, we aimed to design Bmp2 mRNA-enriched engineered exosomes, which were then loaded into specific hydrogel to achieve sustained release for more efficient and safe bone regeneration.

Results

BMP2 mRNA was enriched into exosomes by selective inhibition of translation in donor cells, in which NoBody (non-annotated P-body dissociating polypeptide, a protein that inhibits mRNA translation) and modified engineered Bmp2 plasmids were co-transfected. The derived exosomes were named ExoBMP2+NoBody. In vitro experiments confirmed that ExoBMP2+NoBody had higher abundance of Bmp2 mRNA and thus stronger osteogenic induction capacity. When loaded into GelMA hydrogel via ally-L-glycine modified CP05 linker, the exosomes could be slowly released and thus ensure prolonged effect of BMP2 when endocytosed by the recipient cells. In the in vivo calvarial defect model, ExoBMP2+NoBody-loaded GelMA displayed great capacity in promoting bone regeneration.

Conclusions

the proposed ExoBMP2+NoBody-loaded GelMA can provide an efficient and innovative strategy for bone regeneration.
Identity Influences on Medical Students’ Orientation to Feedback During Rotations
Authors: Thompson Charee M. , Kerr Anna M.
Published: September 2022

Medical students’ attitudes about and preferences for feedback from preceptors may change over the course of the third year of medical school and is likely influenced by identity-related factors. We propose that both how students view themselves personally (i.e., impostor syndrome) and how they view themselves in relation to the group (i.e., identification with the profession) are identity factors related to related to feedback orientation during clinical rotations. 177 third-year medical students enrolled in our four-phase longitudinal survey study beginning at the start of clinical rotations and continuing every twelve weeks of the academic year thereafter. Mixed modeling was utilized to assess models that included phase, sex, and specialty intention as covariates and impostor syndrome and group identity as predictors of feedback orientation. Results indicate that feedback orientation does not significantly change during the third year. Instead, across phases, impostor syndrome was at least marginally, significantly associated with all aspects of feedback orientation across phases—utility, retention, sensitivity, and confidentiality. Group identity was associated with feedback utility and retention, and female-identifying students reported significantly greater feedback confidentiality and feedback retention. Interventions may be needed to improve medical students’ attitudes about feedback, particularly for those who experience impostor syndrome. Fostering group cohesion among medical students may influence how well students remember feedback and find it useful.
Field monitoring and analysis of the stress variation relationship between fiberglass bolts and face deformation in tunnels based on the ADECO-RS construction approach
Authors: FENG Jimeng , TAN Yumei , YAO Shiyu , JIANG Hui , ZHANG Junru , LI Hongtao
Published: September 2022

One of the main causes for excessive deformation within a tunnel is due to the instability of the soil or soft rock ahead of the excavation face. Fiberglass bolts have been shown to be a useful advance reinforcement method for the excavation face. In this paper, an improved ADECO-RS (Analysis of controlled deformation in rock and soils) method have been proposed for soft rock mountain tunnels, in terms of the partial (mainly the upper bench) excavation face reinforcement and also for the bench excavation method. Strain gauges were used to test the micro-strain in the fiberglass bolt to investigate how the axial force of the fiberglass bolt varied during the tunnel excavation. In addition, combined with the field tunnel deformation monitoring data, the relationship between the reinforcement parameters of the fiberglass bolts and the tunnel construction phase has been discussed. The conclusions of this study are: (1) The redistribution of the stress after the excavation led to an increase in the stresses of the surrounding rock near the excavation face, and there was a significant stress increase in the fiberglass bolt; (2) The excavation during the lap area of the fiberglass bolt led to an increase in the axial force in the bolt, however, the excavation outside the lap area of the fiberglass bolt didn’t show any influence on the bolt; (3) The deformation of the tunnel met the construction specification by ensuring the stability of the excavation face and closing the loop of each initial support construction as soon as possible; (4) In a future project with similar conditions, the recommended lap length of the fiberglass bolt was 3 m utilizing the fiberglass bolt grouting face reinforcement method.
Optical solitons to the Perturbed Gerdjikov-Ivanov equation with quantic nonlinearity
Authors: Ali Karmina Kamal , Tarla Sibel , Sulaiman Tukur Abdulkadir , Yilmazer Resat
Published: September 2022

In this article, we examine the Perturbed Gerdjikov-Ivanov equation by using the Jacobi ellipticfunction expansion method. This results in obtaining distinct solutions including dark, bright,singular solitons, periodic waves, singular periodic waves, and Jacobi elliptic function solutions. The2- and 3-dimensional graphs of the reported solutions are presented. The reported results may beuseful in explaining the physical features of the studied equation.
Adjuvant anti-PD-1 antibody for hepatocellular carcinoma with high recurrence risks after hepatectomy
Authors: Chen Wei , Hu Shuifang , Sun Yukun , Wu Jian , Shen Shunli , Peng Zhenwei
Published: September 2022

Background and Purpose
The clinical role of postoperative adjuvant therapy in hepatocellular carcinoma (HCC) is still unclear. The purpose of our study was to explore the clinical value of postoperative adjuvant anti-programed cell death 1 antibody (PA-PD-1) on the prognosis of HCC patients with high relapse risks after surgery.
Patients and Methods
Consecutive HCC patients with high recurrence risks treated with liver resection at our center during January 2019 and March 2021 were prospectively enrolled. Baseline differences were balanced between HCC patients with (PA-PD-1 group) or without PA-PD-1 (non-PD-1 group) after hepatectomy by propensity-score matching (PSM). Between these two groups, we compared overall survival (OS) and recurrence-free survival (RFS). Independent prognostic risk factors for OS and RFS were confirmed by Cox regression analysis and subgroup analysis was also performed.
Results
47 pairs of patients with or without PD-1 treatment after hepatectomy were matched. After PSM, the 1-year and 2-year RFS were 58.4% and 44.1% in the PA-PD-1 group, and 34.0% and 21.3% in the non-PD-1 group (p = 0.008). The OS at 1-year and 2-year were 91.2% and 91.2% in the PA-PD-1 group, compared with 85.1% and 61.7% in the non-PD-1 group (p= 0.024). Multivariable analyses demonstrated that PA-PD-1 was an independent protective predictor associated with RFS and OS. Through subgroup analysis, we concluded that HCC patients with portal venous tumor thrombus (PVTT) or tumor size ≥ 5 cm significantly benefited from PA-PD-1 therapy in RFS and OS.
Conclusions
Adjuvant anti-PD-1 antibody can effectively improve the survival outcomes of HCC patients with high relapse risks after hepatectomy.
Decision-Making Process about Prenatal Genetic Screening: How deeply do Moms-to-Be Want to Know from Non-Invasive Prenatal Testing?
Authors: Oliveri Serena , Ongaro Giulia , Cutica Ilaria , Menicucci Giulia , Belperio Debora , Spinella Francesca , Pravettoni Gabriella
Published: September 2022

Background. Two procedures are available to obtain prenatal information: invasive diagnostic procedures, and non-invasive diagnostic procedures, such as those that use cell-free fetal DNA. Several psychological factors are involved in the decision to undergo a non-invasive prenatal testing (NIPT) but little is known about the decision-making strategies involved in choosing a specific level of in-depth NIPT, considering the increased availability and complexity of NIPT options. The main aim of this work is to assess the impact of psychological factors (anxiety about pregnancy, perception of risk in pregnancy, intolerance to uncertainty), and COVID-19 pandemic on the type of NIPT chosen, in terms of the number of conditions that are tested.
Methods. A self-administered survey evaluated the decision-making process about NIPT. The final sample comprised 191 women (Mage= 35.53; SD= 4.79) who underwent a NIPT from one private Italian genetic company. Based on the test date, the sample of women was divided between “NIPT before COVID-19” and “NIPT during COVID-19”.
Results. Almost all of the participants reported being aware of the existence of different types of NIPT and more than half reported having been informed by their gynecologist. Results showed no significant association between the period in which women underwent NIPT (before COVID-19 or during COVID-19) and the preferences for more expanded screening panel. Furthermore, regarding psychological variables, results showed a significant difference between baby’s risk perception based on the NIPT type groups, revealing that the mums-to-be who underwent the more expanded panel had a significantly higher level of baby’s risk perception than that reported by the mums-to-be who underwent the basic one. There was no statistically significant difference between the other psychological variables and NIPT type.
Conclusions. Our findings indicate the paramount role of gynecologist and other health care providers, such as geneticists and psychologists, to support decision-making process in NIPT, in order to overcome people’s deficits in genetic knowledge, promote awareness about their preferences, and control anxiety related to the unborn child. Decision-support strategies are critical during the onset of prenatal care, according to the advances in prenatal genomics and to parent’s needs.
Image-seq: spatially-resolved single cell sequencing guided by in situ and in vivo imaging
Authors: Haase Christa , Gustafsson Karin , Mei Shenglin , Yeh Shu-Chi , Richter Dmitry , Milosevic Jelena , Turcotte Raphaël , Kharchenko Peter V. , Sykes David B. , Scadden David T. , Lin Charles P.
Published: September 2022

Tissue function depends on proper cellular organization. While the properties of individual cells are increasingly being deciphered using powerful single-cell sequencing technologies, understanding their spatial organization and temporal evolution remains a major challenge. Here, we present Image-seq, a technology that provides single-cell transcriptional data on cells that are isolated from specific spatial locations under image guidance, thus preserving the spatial information of the target cells. It is compatible with in situ and in vivo imaging and can document the temporal and dynamic history of the cells being analyzed. Cell samples are isolated from intact tissue and processed with state-of-the-art library preparation protocols. The technique therefore combines spatial information with highly sensitive RNA sequencing readouts from individual, intact cells. We have used both high-throughput, droplet-based sequencing, as well as SMARTseq-v4 library preparation to demonstrate its application to bone marrow and leukemia biology. We discovered that DPP4 is a highly upregulated gene during early AML progression and that it marks a more proliferative subpopulation which is confined to specific bone marrow microenvironments. Furthermore, Image-seq’s ability to isolate viable, intact cells should make it compatible with a range of downstream single-cell analysis tools including multi-omics protocols.
Fungi in hair roots of Vaccinium spp. (Ericaceae) growing on decomposing wood: colonization patterns, identity and in vitro symbiotic potential
Authors: Vohník Martin , Réblová Martina
Published: September 2022

Most of our knowledge on the ericoid mycorrhizal (ErM) symbiosis comes from temperate heathlands characterized by acidic peaty soils and many experiments with a few ascomycetous fungi. However, ericaceous plants thrive in many other habitats and in temperate coniferous forests, their seedlings often prosper on decomposing wood. While wood is typically exploited by basidiomycetous ectomycorrhizal (EcM) and saprobic fungi, the role of ErM fungi (ErMF) is much less clear. We explored the cultivable mycobiota of surface sterilized hair roots of Vaccinium spp. growing on decomposing wood in two coniferous forests in Northern Bohemia and Mid-Norway. Obtained isolates were identified using molecular tools and their symbiotic potential was tested in vitro. While the detected community lacked the archetypal ErMF Hyaloscypha hepaticicola and the incidence of dark septate endophytes and EcM fungi was negligible, it comprised other frequent asexual ascomycetous ErMF, namely H. variabilis and Oidiodendron maius, together with several isolates displaying affinities to sexual saprobic H. daedaleae and H. fuckelii. Ascomycete-suppressing media revealed representatives of the saprobic basidiomycetous genera Coprinellus, Gymnopilus, Mycena (Agaricales) and Hypochnicium (Polyporales). In the resyntheses, the tested basidiomycetes occasionally penetrated rhizodermal cells of their hosts but never formed ericoid mycorrhizae and in many cases overgrew and killed the inoculated seedlings. In contrast, a representative of the H. daedaleae/H. fuckelii-related isolates repeatedly formed what morphologically appears as the ErM symbiosis and supported host´s growth. In conclusion, while basidiomycetous saprobic fungi have a potential to colonize healthy-looking ericaceous hair roots, the mode(-s) of their functioning remain obscure. For the first time, a lineage in Hyaloscypha s. str. (formerly the Hymenoscyphus ericae aggregate) where sexual saprobes are intermingled with root symbionts has been revealed, shedding new light on the ecology and evolution of these prominent ascomycetous ErMF.
Anthropogenic forcing changes coastal tropical cyclone frequency
Authors: Wang Shuai , Murakami Hiroyuki , Cooke William
Published: September 2022

It remains a mystery if and how anthropogenic climate change has altered the global tropical cyclone (TC) activities, mainly due to short reliable TC observations and substantial climate internal variabilities. Here we show with large-ensemble TC-permitting simulations that the observed changes in global coastal TC frequency since 1980 were caused by anthropogenic greenhouse gases (GHG) and/or aerosols. The observed increases in TC frequency near the US Atlantic coast and Hawaii are likely related to the aerosol and GHG effects, respectively. The observed decrease in the South China Sea could be associated with GHG emissions alone, whereas the observed increase near Japan and Korea would be related to the aerosol and GHG combined effects. These changes are explained by the responses of large-scale environmental conditions to anthropogenic forcing. Our findings suggest the substantial influence of anthropogenic forcing on TC frequency over the heavily populated coastal regions worldwide.
Selective change in the bacterial flora in respiratory sputum from elderly patients during the SARS-CoV-2 pandemic
Authors: Nagasawa Masayuki , Kato Tomoyuki
Published: September 2022

The pandemic of SARS-CoV-2 has affected the social lifestyle and consequently the prevalence of infections, such as seasonal influenza. It has been reported that invasive pneumococcal infection is markedly decreased worldwide.  We retrospectively investigated the bacterial flora of 23,052 respiratory sputum samples obtained at our hospital from April 2015 to March 2022. The average patient age was 71.8 years old with a standard deviation of 16.0 years old. There was no significant difference in the age of the patients or the female-to-male ratio between each year. The detection ratio of bacteria was analyzed in accordance with sputum quality based on the Geckler classification.  The detection ratio of community-acquired pneumonia pathogens such as Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae increased in parallel with the quality of the sputum, while that of hospital-acquired pneumonia pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus was not significantly affected by the quality of the sputum. The former detection ratio decreased significantly since April 2020 by 60–80% for two years in a row, while that of the latter did not change between each year.  The pandemic of SARS-CoV-2 reduced the detection ratio of community-acquired pathogens such as Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae but not hospital-acquired pneumonia pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus in the respiratory sputum from elderly patients.
N2-neutrophils promote invasion and metastasis of ovarian cancer by upregulating MAPK signaling
Authors: Li Caixia , Zhou Yang , Men Chuandi , Yang Weihong , Liu Qi , Cheng Zhongping
Published: September 2022

Background
Neutrophils is an important immune cell in microenvironment of various cancers. Previous studies reported that neutrophils were associated with the development and prognosis of various malignant tumors, but how different phenotypic and functional heterogeneity of neutrophils exert in regulating invasion and metastasis of ovarian cancer were rare reported.
Objective
This study aimed to verify functions and mechanisms of different phenotypes of neutrophils in ovarian cancer invasion and metastasis.
Methods
The expression of CD11b, one of the most important biomarkers of N2-neutrophils, was assessed by immunohistochemistry and western blot (WB) in 24 benign and malignant clinical ovarian cancer tissues respectively. 48 samples from 16 ovarian serous carcinoma patients were averagely divide into adjacent tissues, primary lesions and metastatic lesions groups, detecting the mRNA and protein expression levels of neutrophil biomarkers CD11b, CXCL8 and CXCR1 by reverse-transcription quantitative PCR (qRT–PCR) and WB. Tumor associated N1 and N2 neutrophils phenotypes research models were constructed. Invasion and metastasis changes of ovarian cancer cells were assessed by transwell assay and wound-healing test with or without N1/N2 neutrophils co-culturing. The roles and mechanisms of N2-neutrophils in promoting ovarian cancer progression were probed by high-throughput RNA sequencing and gain- and loss-of-function analysis.
Results
The expression of CD11b was significantly increased in malignant tissue groups compared with benign groups. The expression levels of CD11b, CXCL8 and CXCR1 were the highest in groups of metastatic lesions, followed by the primary lesions, and the lowest in the adjacent tissues. N2-neutrophils co-cultured with ovarian cancer cell lines (SKOV3 and OVCAR3) could promote the invasion and metastasis of ovarian cancer cell lines, but N1-neutrophils played the opposite role. MAPK signaling pathway was significantly enhanced in ovarian cancer cells by phosphorylating of P38 after co-culturing with N2-neutrophils and the p-P38 mono-inhibitor was able to reverse this function.
Conclusions
N2-neutrophils promoted the invasion and metastasis of ovarian cancer by upregulating MAPK signaling through phosphorylating the P38.
Influência de manobras
Authors: Souza Carlos Antonio
Published: September 2022

Golpe de Aríete
O USO PRAGMÁTICO DA ESTÉTICA E ARTE NAS PRODUÇÕES DE EDUCAÇÃO QUÍMICA: EM DIREÇÃO À AMPLIAÇÃO DA VISÃO DE MUNDO
Authors: Abreu Murilo Henrique , Carmo Ana Paula Carvalho do , Sousa Robson Simplicio de
Published: September 2022

O foco deste trabalho é apresentar uma investigação de artigos que se referem à estética na Educação/Ensino de Química. Um argumento para que haja a inclusão da estética nos cursos de ciências é o aperfeiçoamento da percepção que ela possibilita, contribuindo para experiências estéticas que valorizem os sentidos e não somente o agreguem ao cognitivo do aluno. Pesquisamos artigos em periódicos com escopo em Ensino/Educação química que obtinham em seu título, resumo ou palavras-chave os termos “Artes e/ou Estética”. Tomamos como pergunta de pesquisa “Como se mostra a arte/estética no Ensino de Química/Educação Química?”. Utilizamos a análise Textual Discursiva (ATD), que é uma metodologia de análise qualitativa fenomenológica e hermenêutica. Assim organizamos possíveis respostas para a pergunta de pesquisa em três categorias finais. A primeira categoria intermediária trata a arte/estética na Educação Química como uma ferramenta que propicia a interdisciplinaridade, a contextualização sócio-histórica e a abordagem CTS no Ensino de Química/Ciências, no entanto, trazemos a visão fenomenológica desta abordagem. A segunda categoria traz as relações entre estética e educação, Ciência/Química como agentes potenciais para encaminhar o cientista para sua ampliação de mundo, apresentamos então que isto torna possível se haver uma ótica estética por parte do cientista nestas relações. A terceira categoria intermediária trata do termo ampliação do mundo dos alunos, mostramos que a estética articulada no ensino de Química e/ou Ciência é importante para a expansão de entendimento e ampliação da visão de mundo.
Ensino de Geometria Analítica: discussão nos pressupostos da Sequência Fedathi no contexto da formação do professor de Matemática
Authors: Alves Francisco Vieira , Pereira Carolina costa Costa
Published: September 2022

Neste artigo são discutidas situações didáticas envolvendo a aplicação dos pressupostos que caracterizam as fases de ensino da Sequência Fedathi - SF. Seu contexto de aplicação envolve a Geometria Analítica. Deste modo, na seção inicial, indicam-se certos entraves pertinentes à qualidade do livro didático. Em seguida, descrevem-se as fases de ensino da SF, acentuando caracteres específicos requeridos no ensino deste conteúdo. Por fim, são trazidas três situações-problema conhecidas evidenciando vários elementos que emergem da relação . Na ausência de uma metodologia de base, no entanto, podem passar despercebidos ao professor de Matemática pouco experiente.
Effect of Slope Geometries on 3D Slope Stability under the Influence of Infiltration
Authors: Hassan M S K , Loo V H
Published: September 2022

Rainfall-induced slope failure is the most common type of slope failure in Malaysia. Many studies have been carried out to assess the correlation of infiltration to 2D geometric features such as slope inclination. However, the relationship between infiltration and 3D slope geometric features has not yet been widely studied. The aim of this study is to assess the effect of varying slope geometries on slope stability with the influence of rainfall, and to compare the results of the 2D and 3D slope analysis. Seepage and slope stability analysis of homogenous slopes for normal, curved surface and turning corner slopes of varying angles were modelled using the numerical software PLAXIS LE. The 3D analysis demonstrated that multiple shallow failures spread across the sloped surface, which could not be captured by the 2D analysis. The failure modes are similar for the various geometric types of slopes. The results also indicate that the safety factor from the 3D analysis decreases more significantly with the rainfall duration as compared to the 2D analysis. This study changes the perception that a 2D analysis is more conservative than a 3D analysis, which is not always true.
Topological Orders in (4+1)-Dimensions
Authors: Johnson-Freyd Theo , Yu Matthew
Published: September 2022

We investigate the Morita equivalences of (4+1)-dimensional topological orders. We show that any (4+1)-dimensional super (fermionic) topological order admits a gapped boundary condition --- in other words, all (4+1)-dimensional super topological orders are Morita trivial. As a result, there are no inherently gapless super (3+1)-dimensional theories. On the other hand, we show that there are infinitely many algebraically Morita-inequivalent bosonic (4+1)-dimensional topological orders.
Experiences of Mothers with Disabled Children During the COVID-19 Pandemic
Authors: ÖZMETE Emine , PAK Melike
Published: September 2022

Introduction: During the COVID-19 pandemic, conditions such as the limitation of resources and the difficulty of access led to disabled individuals and their families to become more vulnerable to the risks posed by the pandemic. Understanding the experiences, difficulties, and needs of individuals with disabilities and their families during the pandemic, as well as evaluating the effects of the crisis, are essential in creating interventions to mitigate these difficulties. This study has aimed to examine the experiences of mothers, who have the burden of care in families with disabled children, during the COVID-19 pandemic.Method: In the study, semi-structured interviews were conducted with mothers of children with disabilities (n = 14) using the phenomenological method, which is one of the qualitative research methods. In the data analysis, Miles and Huberman model was followed, and the codes and categories reflecting the investigated phenomenon were determined by using continuous comparison and phenomenological reduction methods.Findings: According to the results of the study, the difficulties of the mothers' lives increased during the pandemic, and the perception of restrictions resulting from the measures against the pandemic, as well as the inadequacy of access to services, led to increased concern among mothers. The limited support for children with disabilities and their families, as well as their inability to meet their needs with their resources, caused mothers to feel exhausted. In addition to the difficulties they experienced, mothers stated that they had positive experiences as well, since they could spend more productive time with their family members, use digital resources, and feel stronger at the end of the process.Discussion: Compelling experiences such as anxiety, feelings of inadequacy, fatigue, and restraint among mothers with disabled children show that these mothers are among the vulnerable individuals adversely affected by the COVID-19 pandemic. Although the pandemic period was challenging, mothers gained resilience in coping with the difficulties and adapted to the situation.Conclusion and Suggestions: Based on the experiences of families with disabled members for possible future pandemics, services should be provided to facilitate family crisis management, education, advocacy, psychosocial counseling, and empowerment-based studies.
Power Relations in the Stadium Stands: Strengthening Gender Equality in Indonesian Football Club Supporters
Authors: Kusuma Bayu Mitra A. , Octastefani Theresia
Published: September 2022

Indonesian football competition is often seen as a masculine sport only suitable for men supporters. But now, women's supporter groups are increasingly popping up. Therefore, this study aims to analyze how hierarchical and power relations between women and men members in Brigata Curva Sud (BCS), a supporter base of PSS Sleman football club, which in 2017 was praised as the best ultras supporter in Asia. This study uses the power relation theory from Michel Foucault to analyze this phenomenon. The research method used is qualitative with a descriptive approach. The research results showed that BCS had put gender equality as the foundation of its organization: First, BCS has a manifesto of "no leader just together, " which implies that BCS does not recognize a hierarchical organizational structure. Each member has the same rights and obligations in formulating the organization's future and making any agreed decisions. Second, there is no unequal power relation between women and men members in BCS. The only supreme power in the BCS that produces knowledge is a deliberative forum open to all members regardless of social background or gender.
Müşahede ve tahliller, Dahil verit iyot mahlulü zerkile şarbon tedavisi
Authors: NEDİM Nimet
Published: September 2022

Anadolu Kliniği, 1936; Cilt 4 Sayı 4'de yayınlanan Dr. Nimet Nedim'in kaleme aldığı "Müşahede ve tahliller, Dahil verit iyot mahlulü zerkile şarbon tedavisi" isimli yazısını içermektedir.
The Effect of Ginger (Zingiber officinale) on Improving Blood Lipids and Body
Weight; A Systematic Review and Multivariate Meta-analysis of Clinical Trials
Authors: Asghari-Jafarabadi Mohammad , Khalili Leila
Published: September 2022

Background:

Beneficial effects of ginger consumption on metabolic biomarkers has been reported
previously. The current research aimed to investigate the effects of ginger supplementation on lipid profile and
body weight using a meta-analysis of randomized, controlled trials

Methods:

Online databases PubMed, Embase, Web of Science, and Science Direct were searched until December 2021 to identify eligible articles. Twenty-six trials were included.

Results:

The results showed that ginger consumption can significantly improve lipid profile including total triglyceride (-12.54 (-20.01 to -5.08)), cholesterol (-6.53 (-10.76 to -2.31)), LDL (-5.14 (-8.79 to -1.50)), and HDL
(1.13 (0.35 to 1.91)). Moreover, ginger supplementation could significantly decrease body mass index (BMI)
(-0.49 (-0.79 to -0.18)). However, the small number of sample studies that investigated reductions in body
weight (-0.52 (-1.48 to 0.43)) were not statistically significant. Sub-group analysis of treatment dose and duration showed that in most of the analyzed lipid profiles, both ≤1500 and >1500 mg/d for both of ≤8 and >8
weeks could be effective; however, in the case of weight control dose of >1500 mg/d for more than 8 weeks
was more effective. Besides, the results of multivariate meta-analysis revealed the effect of the intervention on
all lipid profiles simultaneously.

Conclusion:

The present meta-analysis and review reveal that ginger supplementation can improve lipid profile
and body weight if used at the appropriate dose and duration. More studies are needed to fully evaluate the effect of ginger supplements' different doses and duration on lipid profile and BMI.
In vitro Evaluation of Antioxidant and Antibacterial Activities of
Eco-friendly Synthesized Silver Nanoparticles using Quercus robur Bark
Extract
Authors: Macovei Irina , Corciovă Andreia , Fifere Adrian , Moleavin Ioana Turin , Tuchiluș Cristina , Mircea Cornelia , Burlec Ana Flavia
Published: September 2022

Aims:

This study reports a simple, cost-effective, and environmentally friendly method to obtain silver nanoparticles (AgNPs) using an aqueous extract of Quercus robur bark.

Methods:

AgNPs synthesis conditions such as silver nitrate concentration, extract: AgNO3 volume ratio, pH, temperature, and reaction time have been examined. After optimizing the synthesis, the obtained AgNPs were characterized by different methods such as UV-Vis, TEM, EDX, and FTIR. The antioxidant activity was evaluated using lipoxygenase inhibition capacity and inhibition of erythrocyte hemolysis mediated by peroxyl free radicals tests. The antimicrobial potential of the samples was tested against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans.

Results:

The AgNPs synthesis process is influenced by reaction conditions, the optimum established values being in this case: concentration of 3 mM AgNO3, 1:9 extract: AgNO3 volume ratio, pH value of 6, 60 ℃ temperature, and 90 minutes stirring time. The shape of the synthesized AgNPs was predominantly spherical, with an average size of 50 nm. The SPR band at 432 nm, the strong EDX signal at ~ 3keV and zeta potential of -13.88 mV revealed the formation of AgNPs and electrostatic stabilization of the colloidal solution. FTIR analysis confirmed the participation of molecules from the extract in the synthesis and stabilization of AgNPs. The obtained nanoparticles showed improved antioxidant, antifungal and antibacterial activities compared to the extract.

Conclusion:

The results open the possibility of exploring new applications of nanoparticles obtained via green synthesis.
Synthesis, Characterization, and Evaluation of Sulfonium Lipids as Potential
Nonviral Gene Vectors
Authors: Li Jing , Zhang Ying , Lu Yanjie , Zhang Lei , Shen Guinan , Jin Chenghao
Published: September 2022

Introduction:

Non-viral gene vectors have attracted much attention in the last few decades
because of their potential activity and fewer side effects. Headgroup chemistry is a key aspect of lipid
design.

Methods:

In this study, a group of sulfonium lipids were designed and constructed by combining tetrahydrothiophene
or tetrahydrothiopyran with an ethoxy linker and carbon aliphatic chains and were evaluated
in terms of their ability as potential gene vectors. The sulfonium lipids were synthesized and characterized
by 1H NMR, 13C NMR, and Mass. Condensates of sulfonium lipids (SL) and DNA were examined by gel
electrophoresis and particle size and zeta potential were measured. Sulfonium compounds were tested on
HepG2 cells for cytotoxicity. SL/DNA condensates were studied in cellular uptake and distribution using
fluorescent microscopy.

Results:

12 sulfonium lipids were obtained. Gel electrophoresis experiments showed that sulfonium cation
can effectively interact with phosphorous in DNA. Compounds containing longer lipid chains can
effectively retard DNA at an S/P ratio higher than 10/1 and can condense DNA into nano size particles
with particle size in the range of 150 nm ~ 300 nm and zeta potential in the range of +20~+40. Sulfonium
compounds were calculated against HepG2 cells in the range of 0.035 μg/mL to 1.64 μg/mL. The intracellular
uptake experiments revealed that SL/DNA nanoparticle was taken into the cell at low efficiency.

Conclusion:

Sulfonium head group can interact with the phosphates of DNA. The structural environment
of sulfonium ions influences the DNA bonding effect. The designed cyclic sulfonium ion was buried in
the middle of the structure and thus hindered interaction with DNA. This type of molecule is worthy of
further modification to increase DNA capacity and reduce cell cytotoxicity.
Knowledge of Complications of Diabetes Mellitus among Patients with
Type 2 Diabetes in Saudi Arabia: A Descriptive Study
Authors: Hassounah Ghadeer , Al Dossari Huda Joman , Robert Asirvatham Alwin
Published: September 2022

Background and Aims:

The objective of this study was to assess the knowledge of diabetes-related complications among patients with type 2 diabetes (T2D) in Saudi Arabia.

Methods:

In this study, 237 patients with T2D, who visited the diabetic clinic at Prince Sultan Military Medical City, Saudi Arabia, from December 2021 to March 2022, were recruited by adopting the non-probability sampling technique. A structured questionnaire was used to collect data on the sociodemographic features of the group in this study and their knowledge regarding T2D-related complications.

Results:

From the 237 patients with T2D in this study, a higher percentage had hypertension (64.1%), heart disease (67.1%), retinopathy (79.7%), nephropathy (69.7%), diabetic foot (75.9%), and neuropathy (68.4%). Overall, a high number of these patients (121 or 51.3%) expressed inadequate knowledge of complications related to diabetes. Only 40 (16.9%) revealed adequate knowledge of diabetes-related complications, while 75 (31.8%) mentioned genuine ignorance regarding their complications. Patients educational status (p = 0.045), occupation (p = 0.026), and duration of diabetes (p = 0.037) were significantly associated with knowledge of diabetic complications. From the multinomial regression, substantial differences were evident concerning the duration and occupation of the population under study.

Conclusion:

The knowledge patients with T2D possess concerning diabetes-related complications was generally poor. This study indicates that through improved knowledge of diabetes, the risks of diabetes-related complications among T2D patients can be minimized.
Human Amniotic Fluid Stem Cells Exert Immunosuppressive Effects on T
Lymphocytes in Allergic Rhinitis
Authors: Zong Ling , Wang De , Long Yanbo , Liu Xiaolan , Tao Ailin , Zhang Lanzhen , Zhai Jinming
Published: September 2022

Aim:

The study aims to investigate the immunomodulatory effect of Amniotic fluid stem
(AFS) cells to Th2-skewed allergic rhinitis (AR) on T-lymphocyte proliferation, viability, activation and
cytokine production.

Background:

AFS cells can suppress peripheral blood mononuclear cells (PBMCs) proliferation and
display immunomodulatory properties, but AFS cells' immunoregulation on AR has not been defined.

Methods:

Human AFS cells were derived from magnetic cell sorting and co-cultured with PBMCs from
AR patients stimulated by phytohemagglutinin (PHA). The AFS cells-associated suppressive proliferation
was analyzed using CellTrace™ Violet assay; the T lymphocytes proliferation, viability, activation and
the Foxp3+ Treg cells were determined by flow cytometry; cytokine levels were measured using an enzyme-
linked immunosorbent assay.

Results:

We determined that AFS cells significantly inhibited PHA-induced CD3+ T lymphocyte proliferation
at the ratio higher than 1:50 (AFS cells: PBMCs) (P<0.05); AFS cells obviously increased the T
lymphocytes viability (P<0.01), inhibited the apoptosis of T lymphocytes (P<0.001), compared to
PBMCs alone; AFS cells suppressed CD3+CD25+ T lymphocytes activated by PHA (P<0.05); AFS cells
significantly promote Treg cells expansion in house dust mite (HDM)-stimulated PBMCs from AR patients
(P<0.05). Compared with HDM-stimulated PBMCs, AFS cell co-culture predominantly decreased
IL-4 level (P<0.05), but increased IFN-γ and IL-10 levels (P<0.01).

Conclusion:

AFS cells modulate the T-cells' immune imbalance towards Th2 suppression in AR, which
can be used as a new cell banking for allergic airway diseases.