bluuebunny/crossref_metadata_2025 huggingface dataset:
Internalized Homonegativity and Sexual Quality of Life in Italian Lesbian and Bisexual Women
Authors: Pavanello Decaro Sofia , Prunas Antonio
Published: March 2024

This study investigates the relationship between sexual quality of life (SQoL) and internalized homonegativity among Italian lesbian and bisexual cisgender women, drawing on the minority stress model. The aim of this study is to compare levels of internalized homonegativity and SQoL between the two groups, exploring the association between these variables. We used a quantitative methodology based on a questionnaire. The data were collected through an online questionnaire from 686 women, including 217 lesbians and 469 bisexuals, using the Lesbian Internalized Homophobia Scale and the Female-Sexual Quality of Life Questionnaire. Statistical analyses, including t-tests and linear regression, were performed to assess group differences and predictors of SQoL. The findings support the hypothesis that bisexual women may experience higher levels of internalized homonegativity. Additionally, the study reveals disparities in SQoL, with lesbian women reporting better outcomes. The linear regression model confirmed a significant negative association between internalized homonegativity and SQoL. The results highlight the need for further research on factors influencing sexual well-being in sexual minority women, and the need to give thorough attention to specific sexual identities in clinical and research practice.
Prevalence of Depressive Symptoms and Its Correlates among Male Medical Students at the University of Bisha, Saudi Arabia
Authors: Alshahrani Abdullah M. , Al-Shahrani Mohammad S. , Miskeen Elhadi , Alharthi Muffarah Hamid , Alamri Mohannad Mohammad S. , Alqahtani Mohammed A. , Ibrahim Mutasim E.
Published: March 2024

Background: Identifying the potential factors of depression among medical students is the first step towards academic excellence and future safe medical practice. Methods: A cross-sectional study was conducted from December 2019 to February 2020 at the University of Bisha, College of Medicine (UBCOM), Bisha Province, Saudi Arabia. Male medical students from year one to year six were involved. A self-administered questionnaire was used to collect data about students’ socio-demographic and academic characteristics. The Arabic version of the PHQ-9 scale with a score of ≥10 was used to identify depression. Logistic regression analysis was used to assess the prevalence and correlates of depression. Results: Of the 190 male students enrolled, 26.8% had depressive symptoms, of whom 45.1% were experiencing moderate to severe symptoms. The significantly highest depression rate was found among the second-year students, at 43.8% (OR = 2.544; 95% CI 1.178–5.714; p = 0.018), and the lowest rate was found among year one students, at 8.9% (OR = 0.203; 95% CI 0.075–0.560; p = 0.002). Univariate regression revealed a significant correlation between depression and dissatisfaction with family income, loss of family members, having psychological illness, difficulties in personal relationships, regretting studying medicine, failure in an academic year, a lower grade than expected, conflict with tutors, lack of college facilities and heavy academic load. In multivariate analysis, loss of family members (AOR = 3.69; 95% CI 1.86–7.413), difficulties in personal relationships (AOR = 2.371; 95% CI 1.009–5.575), regretting studying medicine (AOR = 3.764; 95% CI 1.657–8.550), and failing an academic year (AOR = 2.559; 95% CI 1.112–5.887) were independently correlated with depression. Conclusions: The study concluded that medical students at UBCOM experience depressive symptoms associated with various risk indicators. Optimizing the educational and social environment and infrastructure facilities at UBCOM might promote students’ mental health and well-being.
Factor VII Deficiency in Systemic Mastocytosis with an Associated Myeloid Neoplasm
Authors: Rosati Giorgio , Camerlo Sofia , Fornari Alessandro , Marci Valerio , Montaruli Barbara , Morotti Alessandro
Published: March 2024

Factor VII (FVII) deficiency is a rare bleeding disorder that can be classified as congenital or acquired, and the majority of acquired cases are due to vitamin K deficiency or liver disease. Isolated acquired FVII deficiency is a rare occurrence and has been associated with inhibitors or auto-antibodies. Here, we describe a patient with polycythemia vera who developed systemic mastocytosis and FVII deficiency simultaneously. FVII deficiency was not caused by inhibitors and improved with antineoplastic treatment. Acquired FVII deficiency has been reported in cases of sepsis, possibly due to proteolytic degradation induced by the activation of monocytes or endothelial cells. Malignancies have been shown to cause a depletion in circulating FVII through the direct binding of cancer cells. This case report suggests a potential association between SM associated with a hematological neoplasm (SM-AHN) and acquired FVII deficiency. Further evaluations are recommended in patients with systemic mastocytosis to gain a better understanding of the relationship between pathological mast cells and clotting factor concentrations.
An Update on the Special Issue “Parent-Child Interactions: Paths of Intergenerational Transmission of Psychopathological Risk”
Authors: Cerniglia Luca
Published: March 2024

In September 2020, this Journal published a Special Issue (SI) entitled “Parent-Child Interactions: Paths of Intergenerational Transmission of Psychopathological Risk” that included fourteen interesting articles (see here for all of the published manuscripts’ references: https://www [...]
Interactions with Nature, Good for the Mind and Body: A Narrative Review
Authors: Stott Dahlia , Forde DeAndra , Sharma Chetan , Deutsch Jonathan M. , Bruneau Michael , Nasser Jennifer A. , Vitolins Mara Z. , Milliron Brandy-Joe
Published: March 2024

Interacting with nature may promote mental and physical health. There are multiple ways to interact with nature: indirectly, incidentally, and intentionally. How these types of interactions with nature may be associated with mental and physical health status and health behaviors is unclear. The purpose of this narrative review is to (1) describe the relationship between interactions with nature (indirect, incidental, and intentional) and mental and physical health outcomes and behaviors, (2) identify gaps in the literature, and (3) provide recommendations for future research. Considerable evidence suggests that interacting with nature, indirectly and intentionally, is associated with improvements in mental health and physical exhibitions of mental status. Furthermore, intentionally interacting with nature is associated with engagement in physical activity and gardening is associated with fruit and vegetable consumption. Research suggests that incidentally interacting with nature may be associated with positive mental health status. More research is needed to understand the relationships between incidental interactions with nature and physical health status and behaviors; as well as among all types of interactions with nature and physical health disorders, sleep, and dietary behaviors.
Health Expenditure, Institutional Quality, and Under-Five Mortality in Sub-Saharan African Countries
Authors: Sibanda Kin , Qoko Alungile , Gonese Dorcas
Published: March 2024

The aim of this study is to examine the relationship between health expenditure, institutional quality, and under-five mortality rates in sub-Saharan African countries. Specifically, the study seeks to explore the mediating role of institutional quality in this relationship, focusing on understanding how variations in healthcare spending and institutional frameworks impact child health outcomes. By examining these dynamics, the study aims to provide valuable insights that can inform evidence-based policy interventions to reduce under-five mortality and improve child health outcomes in the region. Utilizing data spanning the years 2000 to 2021 from 46 sub-Saharan African countries, this study employs a systems GMM model to explore the intricate relationship between health expenditure and under-five mortality rates (U5MRs), with a particular focus on the mediating role of institutional quality. The findings reveal that the quality of institutions significantly influences the impact of health expenditures on the U5MR. Strong institutional quality enhances the effectiveness of health expenditure in improving child health outcomes, particularly concerning the allocation of external health funds. Conversely, poor institutional quality amplifies the positive impact of domestic private and out-of-pocket health expenditures on the U5MR, as these serve as coping mechanisms in the absence of robust public healthcare systems. This research emphasizes the need for strategies that increase health expenditure and prioritize institutional strengthening to ensure efficient resource allocation and healthcare system management, thereby reducing under-five mortality rates. Furthermore, it underscores the importance of policies that minimize reliance on private and out-of-pocket health expenditures, which can lead to financial burdens and worsened health outcomes. Sub-Saharan African countries can make significant strides toward improving child survival and overall public health by addressing these issues.
Psychosocial Hazards in the Northern Territory Building and Construction Industry: A Profile of Job Demands and Job Resources in a Jurisdiction and Industry with High Rates of Suicide
Authors: Thompson Nicholas , Robertson Adam , Loudoun Rebecca , Biggs Amanda , Townsend Keith
Published: March 2024

The work environment for building workers in Australia’s Northern Territory (NT) is characterised by concerningly high rates of distress and suicide at both a jurisdictional and an industry level. Work-related psychosocial hazards are known antecedents of work-related distress and suicide, and more research is required to understand how these hazards impact workers in this unique building context. This paper examines the unique work environment in the NT building industry by comparing psychosocial hazards in the NT with those in the broader Australian building and construction industry. When comparing 330 NT self-report survey responses about psychosocial hazards in the workplace to 773 broader Australian building industry responses, supervisor task conflict for NT workers was more concerning, at 10.9% higher than the broader Australian cohort. Within the NT sample, comparisons between fly-in and fly-out/drive-in and drive-out (FIFO/DIDO) workers and non-FIFO/DIDO workers were also performed to determine specific local psychosocial hazards. When comparing FIFO/DIDO workers’ responses to their NT peers, role overload and supervisor task conflict were significantly higher, and co-worker and supervisor support were lower. In FIFO/DIDO environments, praise and recognition, procedural justice, and change consultation were at concerningly lower averages than the broader NT building and construction industry. These results suggest that the NT building and construction industry, and particularly FIFO/DIDO operations, require greater resourcing, investment, and focus on workplace mental health initiatives to improve the work environment and wellbeing of this workforce and mitigate hazards that can lead to distress and the high rates of occupational suicide found in this jurisdiction and industry.
Microbial Composition Dynamics in Peloids Used for Spa Procedures in Lithuania: Pilot Study
Authors: Kataržytė Marija , Rapolienė Lolita , Kalvaitienė Greta , Picazo-Espinosa Rafael
Published: March 2024

Despite peloids’ acknowledged therapeutic and cosmetic potential, there remains a limited understanding of their microbial diversity and dynamics, especially concerning beneficial and non-beneficial microorganisms under different heating conditions. Our study employs both cultivation and metagenomic methods to assess the microbiota of peloids, focusing on lake sapropel and peat under heating conditions recommended for external application and safety assurance. By applying microbial indicators specified in national regulatory documents, we found that all peloids reached thresholds for sulphite-reducing clostridia and colony-forming units. Each peloid exhibited a distinctive bacterial composition based on metagenomic analysis, and temperature-induced changes were observed in microbial diversity. We identified beneficial bacteria potentially contributing to the therapeutic properties of peloids. However, the same peloids indicated the presence of bacteria of human faecal origin, with a notably higher abundance of Escherichia coli, pointing to a potential source of contamination. Unfortunately, it remains unclear at which stage this contamination entered the peloids. The findings underscore the importance of monitoring and controlling microbial aspects in peloid applications, emphasising the need for measures to prevent and address contamination during their preparation and application processes.
Peripheral Upregulation of Parkinson’s Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression
Authors: Brazdis Razvan-Marius , von Zimmermann Claudia , Lenz Bernd , Kornhuber Johannes , Mühle Christiane
Published: March 2024

Due to the high comorbidity of Parkinson’s disease (PD) with major depressive disorder (MDD) and the involvement of sphingolipids in both conditions, we investigated the peripheral expression levels of three primarily PD-associated genes: α-synuclein (SNCA), lysosomal enzyme β-glucocerebrosidase (GBA1), and UDP-glucose ceramide glucosyltransferase (UGCG) in a sex-balanced MDD cohort. Normalized gene expression was determined by quantitative PCR in patients suffering from MDD (unmedicated n = 63, medicated n = 66) and controls (remitted MDD n = 39, healthy subjects n = 61). We observed that expression levels of SNCA (p = 0.036), GBA1 (p = 0.014), and UGCG (p = 0.0002) were higher in currently depressed patients compared to controls and remitted patients, and expression of GBA1 and UGCG decreased in medicated patients during three weeks of therapy. Additionally, in subgroups, expression was positively correlated with the severity of depression and anxiety. Furthermore, we identified correlations between the gene expression levels and PD-related laboratory parameters. Our findings suggest that SNCA, GBA1, and UGCG analysis could be instrumental in the search for biomarkers of MDD and in understanding the overlapping pathological mechanisms underlying neuro-psychiatric diseases.
Empowering Pedestrian Safety: Unveiling a Lightweight Scheme for Improved Vehicle-Pedestrian Safety
Authors: Rabieh Khaled , Samir Rasha , Azer Marianne A.
Published: March 2024

Rapid advances in technology and shifting tastes among motorists have reworked the contemporary automobile production sector. Driving is now much safer and more convenient than ever before thanks to a plethora of new technology and apps. Millions of people are hurt every year despite the fact that automobiles are networked and have several sensors and radars for collision avoidance. Each year, many of them are injured in car accidents and need emergency care, and sadly, the fatality rate is growing. Vehicle and pedestrian collisions are still a serious problem, making it imperative to advance methods that prevent them. This paper refines our previous efficient VANET-based pedestrian safety system based on two-way communication between smart cars and the cell phones of vulnerable road users. We implemented the scheme using C and NS3 to simulate different traffic scenarios. Our objective is to measure the additional overhead to protect vulnerable road users. We prove that our proposed scheme adds just a little amount of additional overhead and successfully satisfies the stringent criteria of safety applications.
Using Generative AI to Improve the Performance and Interpretability of Rule-Based Diagnosis of Type 2 Diabetes Mellitus
Authors: Kopitar Leon , Fister Iztok , Stiglic Gregor
Published: March 2024

Introduction: Type 2 diabetes mellitus is a major global health concern, but interpreting machine learning models for diagnosis remains challenging. This study investigates combining association rule mining with advanced natural language processing to improve both diagnostic accuracy and interpretability. This novel approach has not been explored before in using pretrained transformers for diabetes classification on tabular data. Methods: The study used the Pima Indians Diabetes dataset to investigate Type 2 diabetes mellitus. Python and Jupyter Notebook were employed for analysis, with the NiaARM framework for association rule mining. LightGBM and the dalex package were used for performance comparison and feature importance analysis, respectively. SHAP was used for local interpretability. OpenAI GPT version 3.5 was utilized for outcome prediction and interpretation. The source code is available on GitHub. Results: NiaARM generated 350 rules to predict diabetes. LightGBM performed better than the GPT-based model. A comparison of GPT and NiaARM rules showed disparities, prompting a similarity score analysis. LightGBM’s decision making leaned heavily on glucose, age, and BMI, as highlighted in feature importance rankings. Beeswarm plots demonstrated how feature values correlate with their influence on diagnosis outcomes. Discussion: Combining association rule mining with GPT for Type 2 diabetes mellitus classification yields limited effectiveness. Enhancements like preprocessing and hyperparameter tuning are required. Interpretation challenges and GPT’s dependency on provided rules indicate the necessity for prompt engineering and similarity score methods. Variations in feature importance rankings underscore the complexity of T2DM. Concerns regarding GPT’s reliability emphasize the importance of iterative approaches for improving prediction accuracy.
The Reasons for the Low Uptake of New Antidiabetic Drugs with Cardiovascular Effects—A Family Doctor Perspective
Authors: Kurevija Tomislav , Šojat Dunja , Bosnić Zvonimir , Mujaj Blerim , Canecki Varžić Silvija , Majnarić Trtica Ljiljana
Published: March 2024

Chronic diseases, such as type 2 diabetes (T2D), are difficult to manage because they demand continuous therapeutic review and monitoring. Beyond achieving the target HbA1c, new guidelines for the therapy of T2D have been introduced with the new groups of antidiabetics, glucagon-like peptide-1 receptor agonists (GLP-1ra) and sodium-glucose cotransporter-2 inhibitors (SGLT2-in). Despite new guidelines, clinical inertia, which can be caused by physicians, patients or the healthcare system, results in T2D not being effectively managed. This opinion paper explores the shift in T2D treatment, challenging assumptions and evidence-based recommendations, particularly for family physicians, considering the patient’s overall situation in decision-making. We looked for the possible reasons for clinical inertia and the poor application of guidelines in the management of T2D. Guidelines for antidiabetic drugs should be more precise, providing case studies and clinical examples to define clinical contexts and contraindications. Knowledge communication can improve confidence and should include clear statements on areas of decision-making not supported by evidence. Precision medicine initiatives in diabetes aim to identify subcategories of T2D patients (including frail patients) using clustering techniques from data science applications, focusing on CV and poor treatment outcomes. Clear, unconditional recommendations for personalized T2D management may encourage drug prescription, especially for family physicians dealing with diverse patient contexts and clinical settings.
Association between Surrogate Markers of Insulin Resistance and the Incidence of Colorectal Cancer in Korea: A Nationwide Population-Based Study
Authors: Son Minkook , Moon Sang Yi , Koh Myeongseok , Kang Yeowool , Lee Jong Yoon
Published: March 2024

Background: Insulin resistance (IR) is assessed using surrogate markers such as the triglyceride–glucose (TyG) index, the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (METS-IR). Limited studies investigated their association with colorectal cancer (CRC) incidence, and no research has been conducted on their association with the METS-IR. Method: This study used claims data from the Korean National Health Insurance Service, analyzing a cohort of 314,141 Koreans aged over 40 who participated in the National Health Screening Program from 2009 to 2010. The follow-up period was extended until 31 December 2019. Participants were divided into four groups based on quartiles (Q1–Q4) of the markers. Results: All surrogate markers of IR had sequentially statistically lower disease-free probabilities from Q1 to Q4. The Cox proportional hazard model demonstrated statistically significant positive associations between CRC incidence and Q3 and Q4 of the TyG index, as well as Q3 and Q4 of the TG/HDL-C ratio and Q4 of the METS-IR. The constrained cubic spline method revealed a nonlinear, positive dose–response relationship between the TyG index and the METS-IR in relation to CRC incidence. Conclusions: In conclusion, the TyG index, TG/HDL-C ratio, and METS-IR were positively correlated with CRC incidence in Koreans.
Reassessing Trabeculectomy: A Long-Term Study with Stringent Success Criteria
Authors: Braun Philip , Böhringer Daniel , Jordan Jens , Reich Michael , Keye Philip , Reinhard Thomas , Lübke Jan
Published: March 2024

Background: The aim was to evaluate the long-term outcome and efficacy of primary trabeculectomy with adjunctive mitomycin c (MMC) for treating glaucoma. Methods: We examined the medical records of 286 eyes that underwent trabeculectomy between 2008 and 2009 at the University Eye Hospital in Freiburg, Germany. Preoperative and follow-up data were collected, including intraocular pressure (IOP) measurements, surgical glaucoma interventions, and prescribed glaucoma medication. The first success criterion was defined as IOP ≤ 15 mmHg with no use of pressure-lowering medication by the patient, the second criterion was defined as the absence of surgical revision, and the third criterion as no further IOP-lowering surgery excluding early revisions following trabeculectomy. Statistical analyses comprised Cox regression and Kaplan–Meier survival estimations. Results: The mean follow-up duration was 1841 days (5 years). The mean preoperative IOP was 26.1 mmHg. Evaluating the success criteria at the time of average follow-up yielded a success rate of only 25% for the first criterion but 80% for both the second and third success criteria. Conclusions: The findings suggest that trabeculectomy with adjunctive MMC can be an effective procedure for permanently lowering IOP. However, surgical revisions and/or further glaucoma surgeries might still be needed. The long-term success rate is lower in comparison to previous research, which may be explained by the stricter success criteria in our study.
Deductive Reasoning Skills in Children Aged 4–8 Years Old
Authors: Józsa Krisztián , Oo Tun Zaw , Borbélyová Diana , Podráczky Judit
Published: March 2024

Young children possess the fundamental deductive reasoning skills for solving their upcoming problems in their daily lives. These skills are of great importance for their school readiness and academic development. Therefore, this study aimed to explore the age differences and predictive variables of deductive reasoning skills in young Hungarian children aged 4–8 years old who reside in Hungary and Slovakia. Face-to-face data were collected from 3050 participants. The instrument of deductive reasoning skills assessment was extracted from the school readiness test, DIFER (Diagnostic System for Assessing Development). Utilizing various statistical analyses with R, AMOS, and MPlus8 packages, it was found that there were significant differences in young children’s deductive reasoning skills across countries and age groups. Parents’ education levels had significant positive relationships with children’s deductive reasoning skills development. And the variables of country and age were identified as significant predictors of children’s deductive reasoning skills. And children’s family background variables such as parental education played a significant role in predicting children’s deductive reasoning skills in Hungary. The implications of this study emphasize the importance of educational contexts, parental involvement, cross-cultural exchange, and further research, with the potential to enhance young children’s educational experiences and prospects in Hungary, Slovakia, and beyond.
Research on the Vitality of Public Spaces in Tourist Villages through Social Network Analysis: A Case Study of Mochou Village in Hubei, China
Authors: Song Jinghua , Zhu Yuyi , Chu Xiangzhai , Yang Xiu
Published: March 2024

The construction of tourist villages is an important implementation path for promoting the new urbanization strategy in China. The optimization of their spatial pattern and functional adjustment is a key way to achieve high-quality urban development. The purpose of this study is to determine the influencing factors of public space vitality in tourist villages from the perspective of human behavior activities and to provide design support strategies for enhancing the vitality of public spaces in tourist villages. Using Mochou Village as an example, physical and behavioral network models were used to conduct a quantitative study of the vitality characteristics, and Quantitative Analysis of Precedence (QAP) regression was used to investigate the influence factors. The results demonstrate that spatial characteristics, such as “small block size, high street density”, and grid-like street structure and squares, as well as factors such as store concentration, sight lines, street length, spatial openness, and street width, significantly impact the vitality of public spaces in tourist villages. The analysis of the characteristics of the vitality of public space networks in tourist villages and the discussion of the influencing factors of public space vitality in this study can provide guidance for evaluating the vitality of public spaces and designing public spaces with high vitality in tourist villages.
Multiscale Ecological Zoning Management with Coupled Ecosystem Service Bundles and Supply–Demand Balance, the Case of Hangzhou, China
Authors: Li Yonghua , Ding Xinyi , Yao Song , Zhang Bo , Jiang Hezhou , Zhang Junshen , Liu Xinwei
Published: March 2024

Grasping the interrelationship between the supply and demand of ecosystem services (ESs) and spatial scale characteristics is the foundation for effective ecological zoning management, which helps to realize a win–win situation for both ecological protection and economic development. This paper focuses on the following three real problems: mismatch in ES supply and demand evaluation, mechanical and subjective delineation of ecological zoning, and rough management strategies, and constructs a multi-scale ecological zoning management framework for the “comprehensive evaluation of supply and demand, ecological zoning, and enhancement of human well-being”. This study integrates the InVEST model, SOM, Z-score quadrant matching, and coordination degree method, and applies them to the ecological management zoning of Hangzhou. The results show that (1) the spatial differentiation of ESs in Hangzhou is significant. The spatial pattern of the five types of ES supply varies at the county scale and the grid scale on which ES demand is concentrated and is consistent at different scales. (2) ES supply–demand matching in Hangzhou is at the basic coordination and can be divided into four modes including HH, LH, LL, and HL at both the county and grid scales. On the small scale, the proportion of mismatches declines slightly, but the severity rises. (3) ES supply is divided into four categories as follows: the food production bundle, the carbon storage bundle, the ESs balancing bundle, and the ESs depleting bundle, and clarifies the priority of ES management. (4) Construct an ecological management practice path, delineates 6 ecological management zones at the county scale and 19 secondary management zones at the grid scale. Targeted measures are proposed in terms of supply–demand adjustment strategies, ecological management strategies, and key implementation areas. This study helps to incorporate the interaction between the supply and demand of ESs into the planning framework and provides decision-making support for refined ecological management.
Physiological, Agronomic, and Grain Quality Responses of Diverse Rice Genotypes to Various Irrigation Regimes under Aerobic Cultivation Conditions
Authors: Mousa Ahmed M. A. , Ali Ahmed M. A.-G. , Omar Abdelrahman E. A. , Alharbi Khadiga , Abd El-Moneim Diaa , Mansour Elsayed , Elmorsy Rasha S. A.
Published: March 2024

Aerobic rice cultivation represents an innovative approach to reduce water consumption and enhance water use efficiency compared to traditional transplanting methods. Simultaneously, cultivating drought-tolerant rice genotypes becomes crucial to ensure their sustainable production under abrupt climate fluctuations. Hence, this study aimed to explore the physiological, agronomic, and grain quality responses of ten diverse rice genotypes to various irrigation levels under aerobic cultivation conditions. A field experiment was performed for two summer seasons of 2019 and 2020 in an arid Mediterranean climate. The irrigation regimes were well watered (13,998 m3/ha), mild drought (10,446 m3/ha), moderate drought (7125 m3/ha), and severe drought (5657 m3/ha). The results revealed considerable variations among rice genotypes under tested irrigation regimes in all physiological, agronomic, and quality traits. According to drought response indices, rice genotypes were classified into three groups (A–C), varying from tolerant to sensitive genotypes. The identified drought-tolerant genotypes (Giza-179, Hybrid-1, Giza-178, and Line-9399) recorded higher yields and crop water productivity with reduced water usage compared to drought-sensitive genotypes. Thus, these genotypes are highly recommended for cultivation in water-scarce environments. Furthermore, their characteristics could be valuable in breeding programs to improve drought tolerance in rice, particularly under aerobic cultivation conditions. The PCA biplot, heatmap, and hierarchical clustering highlighted specific physiological parameters such as relative water content, chlorophyll content, proline content, peroxidase content, and catalase content exhibited robust associations with yield traits under water deficit conditions. These parameters offer valuable insights and could serve as rapid indicators for assessing drought tolerance in rice breeding programs in arid environments.
Thermal-Induced Microstructure Deterioration of Egyptian Granodiorite and Associated Physico-Mechanical Responses
Authors: Gomah Mohamed Elgharib , Li Guichen , Omar Ahmed A. , Abdel Latif Mahmoud L. , Sun Changlun , Xu Jiahui
Published: March 2024

Mineral transformations often induce microstructural deteriorations during temperature variations. Hence, it is crucial to understand why and how this microstructure weakens due to mineral alteration with temperature and the correlated physical and mechanical responses. Therefore, in this study, physical, chemical, thermal, petrographic, and mechanical analyses were carried out to comprehend better the thermal behaviors of Egyptian granodiorite exposed to temperatures as high as 800 °C. The experimental results indicate that the examined attributes change in three distinct temperature phases. Strength zone (up to 200 °C): During this phase, the temperature only slightly impacts the granodiorite mass loss and porosity, and the P-wave velocity and E slightly decrease. However, the rock structure was densified, which resulted in a minor increase in strength. After that, the transition zone (200–400 °C) was distinguished by the stability of most studied parameters. For instance, mass and porosity did not significantly alter, and the uniaxial compressive strength steadily increased with an axial failure mode. When the temperature rises, transgranular cracks cause the P-wave velocity and elastic modulus to decrease moderately. The decay zone started after 400 °C and continued to 800 °C. This zone is characterized by complicated factors that worsen the granodiorite properties, lead to color shift, and produce a shear failure mode. The properties of granodiorite became worse because of chemical reactions, structural and crystal water evaporation, rising thermal expansion coefficient variation, and quartz inversion at 575 °C (α to β, according to the differential thermal analysis). Thermal damage greatly affected granodiorite’s physical and mechanical properties and microstructure at 800 °C. As a result, UCS measurements were extremely small with a complex failure pattern, making Vp and E unattainable.
The Influence of Graphite Filler on the Self-Lubricating Properties of Epoxy Composites
Authors: Smoleń Jakub , Olesik Piotr , Stępień Krzysztof , Mikuśkiewicz Marta , Myalska-Głowacka Hanna , Kozioł Mateusz , Gawron Anna , Godzierz Marcin
Published: March 2024

In this work, epoxy composites filled with flake graphite of various size (less than 10 μm and less than 45 μm) were produced. The aim of the research was to develop a self-lubricating material with favorable tribological properties, i.e., reduced friction coefficient compared to unfilled epoxy resin and limited abrasive wear. The research material was produced using technical epoxy resins based on bisphenol A. The detailed process of composite production was described, and typical technological problems were considered. The addition of graphite led to an increase in dynamic viscosity, which positively limits the phenomenon of sedimentation, but an increase in the filler content also led to an increase in the porosity of the material. A series of tests have shown that the addition of graphite above 5% by weight allows for a reduction in the friction coefficient from 0.6 to 0.4 and significantly reduces the material’s tendency to abrasive wear.
Facile Synthesis of Ag-Doped Urchin-like MnO2 on Carbon Cloth for Supercapacitors
Authors: Feng Yanqiu , Qu Henghui , Wang Yanxiang , Wang Lanzhong , Wang Yongbo , Yang Deli , Ding Bohan , Sun Yue , Guo Jinghe , Dai Shichao
Published: March 2024

Based on MnO2/carbon cloth (CC) composite materials, an Ag-doped MnO2 nanowire, self-assembled, urchin-like structure was synthesized in situ on the surface of CC using a simple method, and a novel and efficient flexible electrode material for supercapacitors was developed. The morphology, structure, elemental distribution, and pore distribution of the material were analyzed using SEM, TEM, XRD, XPS, and BET. The electrochemical performance was tested using cyclic voltammetry (CV) and galvanostatic charge/discharge (GCD). In the three-electrode system, GCD testing showed that the specific capacitance of the material reached 520.8 F/g at 0.5 A/g. After 2000 cycles at a current density of 1 A/g, the capacitance retention rate was 90.6%, demonstrating its enormous potential in the application of supercapacitor electrode materials.
Anti-Inflammatory Activity of Cyanobacteria Pigment Extracts: Physiological Free Radical Scavenging and Modulation of iNOS and LOX Activity
Authors: Rodrigues Lécia , Morone Janaína , Hentschke Guilherme Scotta , Vasconcelos Vitor , Lopes Graciliana
Published: March 2024

Cyanobacteria are among the oldest organisms colonizing Earth. Their great biodiversity and ability to biosynthesize secondary metabolites through a variety of routes makes them attractive resources for biotechnological applications and drug discovery. In this pioneer study, four filamentous cyanobacteria (Cephalothrix lacustris LEGE 15493, Leptolyngbya boryana LEGE 15486, Nodosilinea nodulosa LEGE 06104 and Leptothoe sp. LEGE 11479) were explored for their anti-inflammatory potential in cell and cell-free in vitro bioassays, involving different inflammatory mediators and enzymes. Extracts of different polarities were sequentially prepared and chemically characterized for their content of phycobiliproteins (PBPs) and carotenoids. HPLC-PDA analysis of the acetone extracts revealed β-carotene to be the dominant carotenoid (18.4–44.3 mg/g) and zeaxanthin as the dominant xanthophyll (52.7–192.9 mg/g), with Leptothoe sp. LEGE 11479 and Nodosilinea nodulosa LEGE 06104, respectively, being the richest strains. The PBP profile was in accordance with the color presented by the aqueous extracts, with Leptolyngbya boryana LEGE 15486 being the richest in phycocyanin (204.5 μg/mg) and Leptothoe sp. LEGE 11479 the richest in phycoerythrin (78.5 μg/mg). Aqueous extracts were more effective in superoxide anion radical scavenging, while acetone ones were more effective in scavenging nitric oxide radical (●NO) and in inhibiting lipoxygenase. Acetone extracts also reduced ●NO production in lipopolysaccharide-stimulated RAW 264.7 macrophages, with the mechanistic study suggesting a downregulation of the inducible nitric oxide synthase expression. Nodosilinea nodulosa LEGE 06104 and Leptothoe sp. LEGE 11479 acetone extracts presented the lowest IC50 values for the mentioned assays, pointing them out as promising resources for the development of new multi-target anti-inflammatory therapies.
Palmitate Compromises C6 Astrocytic Cell Viability and Mitochondrial Function
Authors: Schmitt Luisa O. , Blanco Antonella , Lima Sheila V. , Mancini Gianni , Mendes Natalia F. , Latini Alexandra , Gaspar Joana M.
Published: March 2024

Consumption of high-fat diets (HFD) is associated with brain alterations, including changes in feeding behavior, cognitive decline, and dementia. Astrocytes play a role in HFD-induced neuroinflammation and brain dysfunction; however, this process is not entirely understood. We hypothesized that exposure to saturated fatty acids can compromise astrocyte viability and mitochondrial function. The C6 (astrocytes) cell line was treated with palmitate or stearate (200 µM and 400 µM) for 6 h. Cell viability, morphology, inflammatory markers, and oxidative stress were evaluated. To assess mitochondrial function, various parameters were measured (membrane potential, mass, respiration, and complex activities). We observed that 6 h of treatment with 400 µM palmitate decreased cell viability, and treatment with 200 µM palmitate changed the astrocyte morphology. Palmitate increased inflammatory markers (TNF-α and IL6) but did not induce oxidative stress. Palmitate significantly decreased the mitochondrial membrane potential and mitochondrial mass. Complex I activity also decreased in palmitate-treated cells; however, no changes were observed in mitochondrial respiration. In conclusion, palmitate, a saturated fatty acid, induces inflammation and impairs mitochondrial function, leading to reduced astrocytic cell viability and changes in cellular morphology. Our study provides valuable insights into the potential mechanisms underlying the relationship between saturated fatty acids, astrocytes, and mitochondrial function in obesity-related brain dysfunction.
A Current-Mode Analog Front-End for Capacitive Length Transducers in Pneumatic Muscle Actuators
Authors: Di Patrizio Stanchieri Guido , De Marcellis Andrea , Faccio Marco , Palange Elia , Antonelli Michele Gabrio , Beomonte Zobel Pierluigi
Published: March 2024

This paper reports on the design, implementation, and characterization of a current-mode analog-front-end circuit for capacitance-to-voltage conversion that can be used in connection with a large variety of sensors and actuators in industrial and rehabilitation medicine applications. The circuit is composed by: (i) an oscillator generating a square wave signal whose frequency and pulse width is a function of the value of input capacitance; (ii) a passive low-pass filter that extracts the DC average component of the square wave signal; (iii) a DC-DC amplifier with variable gain ranging from 1 to 1000. The circuit has been designed in the current-mode approach by employing the second-generation current conveyor circuit, and has been implemented by using commercial discrete components as the basic blocks. The circuit allows for gain and sensitivity tunability, offset compensation and regulation, and the capability to manage various ranges of variations of the input capacitance. For a circuit gain of 1000, the measured circuit sensitivity is equal to 167.34 mV/pF with a resolution in terms of capacitance of 5 fF. The implemented circuit has been employed to measure the variations of the capacitance of a McKibben pneumatic muscle associated with the variations of its length that linearly depend on the circuit output voltage. Under step-to-step conditions of movement of the pneumatic muscle, the overall system sensitivity is equal to 70 mV/mm with a standard deviation error of the muscle length variation of 0.008 mm.
Chitosan as an Alternative to Oil-Based Materials for the Fabrication of Lab-on-a-Chip
Authors: Zimmer Morgane , Trombotto Stéphane , Laurenceau Emmanuelle , Deman Anne-Laure
Published: March 2024

Given the growing importance of lab-on-a-chip in a number of fields, such as medical diagnosis or environmental analysis, the fact that the current fabrication process relies mainly on oil-based polymers raises an ecological concern. As an eco-responsible alternative, we presented, in this article, a manufacturing process for microfluidic devices from chitosan, a bio-sourced, biodegradable, and biocompatible polysaccharide. From chitosan powder, we produced thick and rigid films. To prevent their dissolution and reduce their swelling when in contact with aqueous solutions, we investigated a film neutralization step and characterized the mechanical and physical properties of the resulting films. On these neutralized chitosan films, we compared two micropatterning methods, i.e., hot embossing and mechanical micro-drilling, based on the resolution of microchannels from 100 µm to 1000 µm wide. Then, chitosan films with micro-drilled channels were bonded using a biocompatible dry photoresist on a glass slide or another neutralized chitosan film. Thanks to this protocol, the first functional chitosan microfluidic devices were prepared. While some steps of the fabrication process remain to be improved, these preliminary results pave the way toward a sustainable fabrication of lab-on-a-chip.
Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol
Authors: Abdel-Kader Maged S. , Radwan Mohamed M. , Metwaly Ahmed M. , Eissa Ibrahim H. , Hazekamp Arno , ElSohly Mahmoud A.
Published: March 2024

Cannabis sativa is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern hemisphere, its use has moved and flourished in the Western nations in more recent centuries. C. sativa is the source of psychoactive cannabinoids that are consumed as recreational drugs worldwide. The C21 aromatic hydrocarbons are restricted in their natural occurrence to cannabis (with a few exceptions). Delta-9-tetrahydrocannabinol (Δ9-THC) is the main psychoactive component in cannabis, with many pharmacological effects and various approved medical applications. However, a wide range of side effects are associated with the use of Δ9-THC, limiting its medical use. In 1966, another psychoactive cannabinoid, Delta-8-tetrahydrocannabinol (Δ8-THC) was isolated from marijuana grown in Maryland but in very low yield. Δ8-THC is gaining increased popularity due to its better stability and easier synthetic manufacturing procedures compared to Δ9-THC. The passing of the U.S. Farm Bill in 2018 led to an increase in the sale of Δ8-THC in the United States. The marketed products contain Δ8-THC from synthetic sources. In this review, methods of extraction, purification, and structure elucidation of Δ8-THC will be presented. The issue of whether Δ8-THC is a natural compound or an artifact will be discussed, and the different strategies for its chemical synthesis will be presented. Δ8-THC of synthetic origin is expected to contain some impurities due to residual amounts of starting materials and reagents, as well as side products of the reactions. The various methods of analysis and detection of impurities present in the marketed products will be discussed. The pharmacological effects of Δ8-THC, including its interaction with CB1 and CB2 cannabinoid receptors in comparison with Δ9-THC, will be reviewed.
Lewis-Acid-Catalyzed (3+2) Annulation of 2-Indolylmethanols with Propargylic Alcohols to Access Cyclopenta[b]indoles
Authors: Wu Teng-Fei , Fu Zhao-Jie , Zhang Yi-Rui , Qiu Zong-Wang , Li Bao Qiong , Chen Shao-Shuai , Pan Han-Peng , Ma Ai-Jun , Zhang Xiang-Zhi
Published: March 2024

Herein, a Sc(OTf)3-catalyzed (3+2) annulation of 2-indolylmethanols with propargylic alcohols is reported. The reaction proceeds via a Friedel–Crafts-type allenylation/5-exo-annulation cascade. In the reaction, 2-indolylmethanol is used as a three-carbon synthon, and propargyl alcohol is used as a two-carbon synthon. This method provides a direct and high-yield pathway for synthetically useful cyclopenta[b]indoles. In general, the method features easily accessible substrates with broad scope and generality, the formation of multiple bonds with high efficiency, and easy scale-up.
Uncovering the Power of GPR18 Signalling: How RvD2 and Other Ligands Could Have the Potential to Modulate and Resolve Inflammation in Various Health Disorders
Authors: Honkisz-Orzechowska Ewelina , Łażewska Dorota , Baran Grzegorz , Kieć-Kononowicz Katarzyna
Published: March 2024

The resolution of inflammation is the primary domain of specialised pro-resolving mediators (SPMs), which include resolvins, protectins, and their forms synthesised under the influence of aspirin and the maresins. The role of these SPMs has been discussed by many authors in the literature, with particular reference to neuroinflammation and significant neurological disorders. This review discusses the role of G protein-coupled receptor 18 (GPR18), resolvin D2 (RvD2) activity, and the GPR18-RvD2 signalling axis, as well as the role of small molecule ligands of GPR18 in inflammation in various health disorders (brain injuries, neuropathic pain, neurodegenerative/cardiometabolic/cardiovascular/gastrointestinal diseases, peritonitis, periodontitis, asthma and lung inflammation, Duchenne muscular dystrophy, SARS-CoV-2-induced inflammation, and placenta disorders. The idea of biological intervention through modulating GPR18 signalling is attracting growing attention because of its great therapeutic potential. With this paper, we aimed to present a comprehensive review of the most recent literature, perform a constructive view of data, and point out research gaps.
Monolithic Integration of GaN-Based Transistors and Micro-LED
Authors: He Honghui , Huang Jinpeng , Tao Tao , Zhi Ting , Zhang Kaixin , Zhuang Zhe , Yan Yu , Liu Bin
Published: March 2024

Micro-LED is considered an emerging display technology with significant potential for high resolution, brightness, and energy efficiency in display applications. However, its decreasing pixel size and complex manufacturing process create challenges for its integration with driving units. Recently, researchers have proposed various methods to achieve highly integrated micro-structures with driving unit. Researchers take advantage of the high performance of the transistors to achieve low power consumption, high current gain, and fast response frequency. This paper gives a review of recent studies on the new integration methods of micro-LEDs with different types of transistors, including the integration with BJT, HEMT, TFT, and MOSFET.