bluuebunny/crossref_metadata_2025 huggingface dataset:
Generative adversarial networks for imputing missing data for big data clinical research
Authors: Dong Weinan , Fong Daniel Yee Tak , Yoon Jin-sun , Wan Eric Yuk Fai , Bedford Laura Elizabeth , Tang Eric Ho Man , Lam Cindy Lo Kuen
Published: April 2021

Background

Missing data is a pervasive problem in clinical research. Generative adversarial imputation nets (GAIN), a novel machine learning data imputation approach, has the potential to substitute missing data accurately and efficiently but has not yet been evaluated in empirical big clinical datasets.

Objectives

This study aimed to evaluate the accuracy of GAIN in imputing missing values in large real-world clinical datasets with mixed-type variables. The computation efficiency of GAIN was also evaluated. The performance of GAIN was compared with other commonly used methods, MICE and missForest.

Methods

Two real world clinical datasets were used. The first was that of a cohort study on the long-term outcomes of patients with diabetes (50,000 complete cases), and the second was of a cohort study on the effectiveness of a risk assessment and management programme for patients with hypertension (10,000 complete cases). Missing data (missing at random) to independent variables were simulated at different missingness rates (20, 50%). The normalized root mean square error (NRMSE) between imputed values and real values for continuous variables and the proportion of falsely classified (PFC) for categorical variables were used to measure imputation accuracy. Computation time per imputation for each method was recorded. The differences in accuracy of different imputation methods were compared using ANOVA or non-parametric test.

Results

Both missForest and GAIN were more accurate than MICE. GAIN showed similar accuracy as missForest when the simulated missingness rate was 20%, but was more accurate when the simulated missingness rate was 50%. GAIN was the most accurate for the imputation of skewed continuous and imbalanced categorical variables at both missingness rates. GAIN had a much higher computation speed (32 min on PC) comparing to that of missForest (1300 min) when the sample size is 50,000.

Conclusion

GAIN showed better accuracy as an imputation method for missing data in large real-world clinical datasets compared to MICE and missForest, and was more resistant to high missingness rate (50%). The high computation speed is an added advantage of GAIN in big clinical data research. It holds potential as an accurate and efficient method for missing data imputation in future big data clinical research.

Trial registration

ClinicalTrials.gov ID: NCT03299010; Unique Protocol ID: HKUCTR-2232
COVID-19 as the sole cause of death is uncommon in frail home healthcare individuals: a population-based study
Authors: Nilsson Lena , Andersson Christer , Sjödahl Rune
Published: April 2021

Background

During the first pandemic wave, Sweden experienced a high mortality rate. Home healthcare reflects a group of people especially vulnerable to coronavirus disease 2019 (COVID-19). We aimed to evaluate the pattern of comorbidity and frailty in a group of individuals having fatal outcomes in home healthcare during the COVID-19 pandemic March to September 2020, and to assess the contribution of COVID-19 in the fatal outcomes.

Methods

A cohort of adults with confirmed COVID-19 diagnosis that deceased in home healthcare between March and September 2020 were analysed in a retrospective study comprising home healthcare in 136 facilities in one Swedish county. Main outcome measures were comorbidity and frailty.

Results

One hundred fifty-five individuals (88 women, 67 men) aged 57–106 (median 88) years were included in the analysis. Nine had considerable frailty (ability to perform various activities of daily living but confined to bed or chair on occasion) and the remaining 146 had severe frailty (unable to perform activities of daily living and/or confined to bed or chair; dementia necessitating care). Three or more diagnoses besides COVID-19 were present in 142 individuals and another eight had two diagnoses in addition to COVID-19. In 20 (13%) individuals, COVID-19 was assessed as the principal cause of death, in 100 (64.5%) a contributing cause, and for the remaining 35 (22.5%) death was probably caused by another comorbidity. This seemed to change over the course of the COVID − 19 pandemic, with its contributing role decreasing from the middle of the summer.

Conclusions

Death in home healthcare during the first wave of the pandemic mostly affected individuals with severe frailty and comorbidity at very advanced ages. One fifth of the individuals who died in home health care had another cause than Covid-19.

Trial registration

Clinical Trials.gov NCT04642196 date 24/11/2020.
The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
Authors: Wang Liulin , Cheng Xiaobin , Dong Qiufen , Zhou Chenliang , Wang Yeming , Song Bin , Li Weinan , Wang Min , Qin Rui , Long Qi , Liu Juan , Li Jing , Li Dan , Li Gang , Ba Yuanming
Published: April 2021

Background

The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients.

Methods

We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression.

Results

In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 109/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality.

Conclusions

COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.
A patient with a homozygous diacylglycerol kinase epsilon (DGKE) gene mutation with atypical haemolytic uraemic syndrome and low C3 responded well to eculizumab: a case report
Authors: Alabdulqader Muneera , Alfakeeh Khalid
Published: April 2021

Background

Atypical haemolytic uraemic syndrome (aHUS) is a rare systemic syndrome characterized by non-immune haemolytic anaemia, thrombocytopenia, and kidney injury. In most cases, alternative complement pathway dysregulation is the identifying cause. Recently, other genetic causes have been identified, including a mutation in the diacylglycerol kinase epsilon (DGKE) gene, which theoretically affect the coagulation pathway and does not affect the complement pathway. Data about the management of these patients are limited. Ideal management and definitive treatment protocols have not yet been established.

Case presentation

A three-year-old boy presented with features of atypical haemolytic uraemic syndrome (aHUS) and low complement C3. He was presumed to have complement-mediated aHUS and was managed empirically with eculizumab. Two weeks after starting eculizumab, his haemoglobin levels, platelet count, and complement C3 level normalized but he continued to have non-nephrotic range proteinuria. His genetic testing revealed a homozygous DGKE mutation, with no other mutation detected. Six months after presentation, the patient was still in remission with no features of aHUS, a trial of weaning eculizumab by increasing dose interval was followed by nephrotic range proteinuria and severe oedema. His proteinuria improved and his oedema resolved after resuming his recommended eculizumab dose.

Conclusions

DGKE gene mutation can lead to aHUS with theoretically no complement dysregulation. However, some patients with this mutation show alternative complement pathway activation. This case report describes a patient with aHUS due to a DGKE gene mutation and low C3 levels who responded to eculizumab, adding to the previously reported cases of patients with DGKE gene mutations who had complete remission with no relapse with C5 blockers and/or plasma exchange. A randomized controlled study on patients with DGKE mutations might be beneficial in understanding the disease and generating a management protocol.
Comorbidity of depression and anxiety leads to a poor prognosis following angina pectoris patients: a prospective study
Authors: Bai Bingqing , Yin Han , Guo Lan , Ma Huan , Wang Haochen , Liu Fengyao , Liang Yanting , Liu Anbang , Geng Qingshan
Published: April 2021

Background

Depression and anxiety are two common mood problems among patients with cardiovascular disease (CVD) and are associated with poor cardiac prognoses. The comorbidity of depression and anxiety is considered to be a more severe psychological status than non-comorbid mood disorders. However, little is known about the relationship between depression or anxiety and noncardiac readmission. We conducted a prospective study on the prognostic impact of depression, anxiety, and the comorbidity of the two among angina pectoris (AP) patients.

Method

In this prospective study, 443 patients with AP were included in the analysis. Follow-up assessments were performed 1 year, and 2 years after patient discharges. Clinical outcomes of interest included noncardiac readmission, major adverse cardiovascular events (MACEs), and composite events. Depression and anxiety symptom scores derived from the patient health questionnaire-9 (PHQ-9) and generalised anxiety disorder-7 (GAD-7) questionnaire were used to assess mood symptoms at baseline. Participants with symptom scores of ≥10 on both the depression and anxiety questionnaires formed the clinical comorbidity subgroup. We used multivariable Cox proportional hazards models to evaluate the impact of individual mood symptom and comorbidity on clinical outcomes.

Results

Among all the AP patients, 172 (38. 9%) were determined to have depression symptoms, 127 (28.7%) patients had anxiety symptoms and 71 (16.0%) patients suffered from their comorbidity. After controlling covariates, we found that patients who endured clinical depression (hazard ratio [HR] = 2.38, 95% confidence interval [CI] 1.06–5.33, p = 0.035) and anxiety ([HR] 2.85, 95% [CI] 1.10–7.45, p = 0.032) had a high risk of noncardiac readmission. Compared to participants with no mood symptoms, those with clinical comorbidity of depression and anxiety presented a greater risk of noncardiac readmission ([HR] 2.91, 95% [CI] 1.03–8.18, p = 0.043) MACEs ([HR] 2.38, 95% [CI] 1.11–5.10, p = 0.025) and composite event ([HR] 2.52, 95% [CI] 1.35–4.69, p = 0.004).

Conclusion

Depression and anxiety were found to have predictive value for noncardiac readmission among patients with AP. Furthermore, prognoses were found to be worse for patients with comorbidity of depression and anxiety than those with single mood symptom. Additional attention needs to be focused on the initial identification and long-term monitoring of mood symptom comorbidity.
Medical thoracoscopy treatment for pleural infections: a systematic review and meta-analysis
Authors: Mondoni Michele , Saderi Laura , Trogu Federica , Terraneo Silvia , Carlucci Paolo , Ghelma Filippo , Centanni Stefano , Sotgiu Giovanni
Published: April 2021

Background

Complicated parapneumonic effusions and empyema represent advanced stages of pleural infections and are characterized by a high mortality. Medical thoracoscopy is a safe and minimally invasive endoscopic technique prescribed to treat severe pleural infections. However, only a few studies evaluated its success rate. A systematic review of observational studies was performed to assess the efficacy of medical thoracoscopy in patients with complicated parapneumonic effusions and empyema, as well as its predictive factors.

Methods

A search of the scientific evidence was carried out using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials. Articles describing observational studies on medical thoracoscopy in patients with parapneumonic effusions and empyema were selected.

Results

Eight studies met the inclusion criteria. The pooled treatment success rate of thoracoscopy was 85% (95% CI 80.0–90.0%; I2: 61.8%) when used as first-line intervention or after failure of chest tube. The pooled complication rate was 9.0% (95% CI 6.0–14.0%; I2: 58.8%). A pooled difference of treatment success of 9.0% (95% CI 1.0–18.0%) was found when post-thoracoscopy intra-pleural fibrinolysis was prescribed. Pooled success rate was higher in cases with pleural fluid culture negativity (pooled difference: 14.0%; 95% CI 4.0–24.0%).

Conclusions

Medical thoracoscopy is effective and safe when prescribed for complicated parapneumonic effusions and empyema. Bacteriological negativity of pleural effusion specimens and administration of adjuvant intra-pleural fibrinolysis after the procedure are associated with a higher success rate.
Comparison of perioperative outcomes of single-port laparoscopy, three-port laparoscopy and conventional laparotomy in removing giant ovarian cysts larger than 15 cm
Authors: Wang Xiaoying , Li Yan
Published: April 2021

Background

Although conventional laparoscopy has gradually accepted as a surgical treatment for ovarian cancer, reducing the port numbers of laparoscopy still has great challenge for larger ovarian tumors. Thus, this study aims to explore the surgical outcomes of single-port laparoscopy for removing giant ovarian cysts (≥ 15 cm) and compare with laparotomy and three-port laparoscopy.

Methods

This study enrolled 95 patients with giant ovarian cysts (> 15 cm) who underwent single-port laparoscopy, three-port laparoscopy or laparotomy. Their medical records, perioperative surgical outcomes, and postoperative pain score and complications were analyzed and compared retrospectively.

Results

Single-port laparoscopy showed better perioperative outcomes and less postoperative pain than three-port laparoscopy and laparotomy. The time between post-surgery and getting out of bed in single-port laparoscopy was significant shorter than that in the laparotomy and three-port laparoscopy (17.53 ± 7.26 vs 29.40 ± 9.57 vs 24.56 ± 7.76, P < 0.01). The length of hospital stay in single-port laparoscopy was significantly shorter than that in other two groups (4.06 ± 0.5 vs 5.46 ± 1.63 vs 4.81 ± 0.83, P < 0.001). In addition, single-port laparoscopy had the lowest postoperative pain scores than in the laparotomy and three-port laparoscopy. There were no significant differences of total hospital cost, postoperative complications and time until gas passing among the three surgical groups. Importantly, in the removal of giant ovarian cysts, the proportion of cyst rupture in single-port laparoscopy was far lower than that in three-port laparoscopy (3.0 vs 22.2%).

Conclusions

For giant ovarian cysts, single-port laparoscopy is still a safe and efficient technique with the advantages of short operation time, less estimated blood loss, short hospital stay, lower spillage rate, and less postoperative pain.
Copeptin, pro-atrial natriuretic peptide and pro-adrenomedullin as markers of hypoxic stress in patients with obstructive sleep apnea—a prospective intervention study
Authors: Karakioulaki Meropi , Grendelmeier Peter , Strobel Werner , Schmid Thomas , Jahn Kathleen , Grize Leticia , Tamm Michael , Stolz Daiana
Published: April 2021

Study Objectives

Obstructive sleep apnea (OSA) might lead to oxidative stress, inflammation and elevated circulating copeptin, proANP and proADM levels. We aimed to evaluate whether the levels of these prohormones are higher in patients with OSA and whether they might change under continuous positive airway pressure (CPAP) therapy, serving as potential proxies for the diagnosis and therapy-response in OSA.

Methods

A total of 310 patients with suspicion of OSA were recruited. Screening for OSA was performed using overnight pulse oximetry followed by polygraphy and a venous puncture in the morning. All patients diagnosed with OSA underwent CPAP adaptation. A venous puncture was conducted in the night before CPAP and in the following morning. At 1 and 6 months of treatment, polygraphy was performed, followed by a venous puncture in the morning. In the acquired blood, copeptin, proANP and proADM levels were measured.

Results

We analyzed 232 patients with OSA and 30 patients without OSA. Our results indicated that only copeptin levels differed significantly among patients with and without OSA at baseline. In OSA patients, the levels of proADM significantly changed after 1 and 6 months on CPAP therapy, when compared to baseline (p < 0.001 and p = 0.020). Additionally, proANP levels significantly decreased after 12 h on CPAP therapy, as compared to baseline levels (p < 0.001).

Conclusions

Copeptin is significantly associated with the presence of OSA. ProANP levels might serve as a potential proxy for the acute response to non-invasive ventilation (12 h), while proADM reflects the long-term response (1 and 6 months).
Research on gray correlation analysis and situation prediction of network information security
Authors: Ye Chengqiong , Shi Wenyu , Zhang Rui
Published: April 2021

In order to further improve the accuracy and efficiency of network information security situation prediction, this study used the dynamic equal-dimensional method based on gray correlation analysis to improve the GM (1, N) model and carried out an experiment on the designed network security situation prediction (NSSP) model in a simulated network environment. It was found that the predicted result of the improved GM (1, N) model was closer to the actual value. Taking the 11th hour as an example, the predicted value of the improved GM (1, N) model was 28.1524, which was only 0.8983 larger than the actual value; compared with neural network and Markov models, the error of the improved GM (1, N) model was smaller: the average error was only 2.3811, which was 67.88% and 70.31% smaller than the other two models. The improved GM (1, N) model had a time complexity that was 49.99% and 39.53% lower than neural network and Markov models; thus, it had high computational efficiency. The experimental results verify the effectiveness of the improved GM (1, N) model in solving the NSSP problem. The improved GM (1, N) model can be further promoted and applied in practice and deployed in the network of schools and enterprises to achieve network information security.
Questionnaires in otology: a systematic mapping review
Authors: Viergever Koen , Kraak Jeroen T. , Bruinewoud Els. M. , Ket Johannes C. F. , Kramer Sophia E. , Merkus Paul
Published: April 2021

Background

Patient-reported outcome measures (PROMs) are valuable tools in assessing the quality of health care from a patient perspective and are increasingly used by otologists. However, selecting the right questionnaire has proven to be a difficult and time-consuming task. To facilitate this process, we will provide a comprehensive overview of existing questionnaires.

Methods

A systematic literature search has been conducted on August 26, 2019, using the EMBASE and PubMed medical databases. 13,345 unique records were extracted. Questionnaires addressing any otologic complaint (tinnitus, hearing loss, earache, otorrhoea, and ear-related pressure sensation, vertigo, itch, or dysgeusia) were identified. All questionnaires were evaluated for eligibility by two independent researchers. Inclusion criteria were adult population, closed-ended questions, English language of the questionnaire, and the availability of the original article describing the development of the instrument or a validation paper describing the validation process written in English.

Objective

Create a comprehensive overview of all validated closed-ended otology questionnaires for adults and demonstrate their basic characteristics.

Main outcome measure

The number of questionnaires in English literature for the adult population, subdivided per symptom and target population.

Results

A total of 155 unique questionnaires were selected: 33 tinnitus questionnaires, 23 vertigo questionnaires, 84 hearing loss questionnaires, and 15 multiple complaint questionnaires. A protocol for further questionnaire comparison is presented.

Discussion

Two separate sequential searches were needed to identify unique questionnaires and to identify their development/validation paper. Although many ear diseases create multiple symptoms, the majority of the questionnaires were symptom specific.

Conclusion

Many questionnaires concerning ear-related symptoms exist and predominantly concern hearing loss, vertigo, or tinnitus. Only a few questionnaires cover the multiple complaints that ear diseases can create. The presented overview is the most comprehensive overview of otology questionnaires in literature to date. It will serve as a basis for questionnaire selection by professionals and could serve as a protocol for questionnaire selection in other fields.

Systematic review registration

PROSPERO CRD42017058155
Dynamics of a second-order nonlinear difference system with exponents
Authors: Dilip D. S. , Mathew Smitha Mary
Published: April 2021

In this paper, we study the persistence, boundedness, convergence, invariance and global asymptotic behavior of the positive solutions of the second-order difference system $$\begin{aligned} x_{n+1}&= \alpha _1 + a e ^{-x_{n-1}} + b y_{n} e ^{-y_{n-1}},\\ y_{n+1}&= \alpha _2 +c e ^{-y_{n-1}}+ d x_{n} e ^{-x_{n-1}} \quad n=0,1,2,\ldots \end{aligned}$$

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where $$\alpha _1, \alpha _2, a, b , c,d$$

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are positive real numbers and the initial conditions $$x_{-1},x_0, y_{-1}, y_0$$

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are arbitrary nonnegative numbers.
Analysing students’ environmental awareness profile using strategic environmental assessment
Authors: Khoiri Ahmad , Sunarno Widha , Sajidan Sajidan , Sukarmin Sukarmin
Published: April 2021

Background: Environmental awareness (EA) is a part of character education ignored by most students. This indifference tends to affect other students’ by not only in protecting and preserving the current environment but also in preventing and repairing the damage that occurs in the environment. This research analyses students' EA profile, based on the findings of LISREL 8.8 Confirmatory Factor Analysis.

Methods: Research subjects included 131 students from Senior High School State 1 Selomerto Wonosobo, Central Java Province, Indonesia. Based on the Slovin formula, the number of samples is representative of the total population (N: 185; error tolerance: 0.05). Data were collected through non-test questionnaires and observation of Strategic Environmental Awareness (SEA). Quantitative descriptive data analysis on EA indicators (Care, Curiosity, Critical, Dependability, Responsibility, and Local Wisdom).

Results: The EA profile of high school students was categorised sufficiently. This revealed the following results: a) the SEA instrument is effective in identifying students’ awareness about current environmental issues and meets model fit criteria (P-value 0.25>0.05; RMSEA 0.095; NFI 0.67); b) the SEA instrument is valid and reliable in accurately determining students’ EA profile; c) although the Responsibility profile was significant (t >1.96), other variables did not meet this significance criteria (EA 1a: ‘Care towards environmental damage’ under the Care profile; EA 3b: ‘Contributing towards preserving the environment’ under the Critical profile; and EA 6b: ‘Aware of local potentials’ under the Local Wisdom profile); d) evaluation of the expected changes in SEA is modified through an ethnoscience approach and the socioscientific issues strategy.

Conclusions: Students’ lack of awareness of the environment and understanding of their regional potential fails to contribute towards creating a sustainable environment. Profile analysis in exploring attitudes, values, and ethics towards the environment are important, as it helps recognize students’ behaviour.
Evidence of Information Asymmetry and Herding Behaviour – The Swiss Franc Unpegging Event in Perspective
Authors: Garg Shruti
Published: April 2021

The paper aims to find the impact of financial events that occurred in one country on another. Taking the case of the Swiss Franc Unpegging of 2015 in Switzerland, the paper observes its impact on the Indian economy. This is done by studying the information asymmetry and herding behaviour in Indian market on the day of the event. The study uses two sets of data, (i) high frequency data and (ii) 3 years index data of both countries. The Ganger Causality test has been conducted to study the cause and effect relationship between the economies, which helps determine the impact on any of the countries. The study found that herding behaviour and information asymmetry in Indian market are now linked to each other in such a way that the country is affected even if the event has not occurred in the economy itself, however, only for a short duration of time. There also seems to be a huge gap between information available amongst all investors.
Occupation-Related Stress among University Faculty Staff in Kwara State, Nigeria
Authors: Atunde Martins Olanrewaju , Medupin Johnson Abiodun , Alabi Saliu Ishaq , Awarun Olabode , Oladejobio Janet Oluwakemi , Oladimeji Rasheedat Modupe , Maiye Christiana Abosede
Published: April 2021

This study examined occupational-related stress among university faculty staff and its implications on goal attainment of universities in Kwara State, Nigeria.  The research design was a descriptive research of a cross-sectional survey. Multi-stage sampling technique was used for the selection of 458 faculty staff. Data were collected with the use of 57-item questionnaire. Data collected were analyzed with relevant statistics like percentage, mean, standard deviation, t-test statistics and analysis of variance (ANOVA). Findings revealed that the level of stress among faculty staff was high (3.25), while stress level differs based on gender (p<.05), age (p<.01), marital status (p<.01), work experience (p<.05) and ownership of workplace (p<.05). The prominent risk associated with occupational-related stress were the organizational-related (cluster mean 3.26) and role-related (CM 3.26) factors. Finding further indicated that the social support (CM 3.00) and individual-focused (CM 2.91) coping strategies were moderately adopted for managing occupational-related stress among university faculty, while the organizational support coping strategy was utilized to a low extent (CM 2.47). The findings implicate the attainment of university goals because of the negative effect high-stress level will have on the physiological and behavioural state of faculty staff adding to destructive work and health anomalies.
Formação inventiva de uma professora-pesquisadora no encontro com mulheres ciganas: pesquisa-intervenção e estudos foucaultianos
Authors: Marcondes Gláucia Siqueira , Ferrari Anderson
Published: April 2021

O foco da análise empreendida neste artigo é a formação inventiva de uma professora-pesquisadora no encontro com mulheres ciganas. O texto é desdobramento de uma pesquisa mais abrangente em que problematizamos o processo de constituição de três mulheres ciganas em um acampamento na cidade de Juiz de Fora/MG. Para isso, utilizamos a perspectiva foucaultiana como embasamento teórico-metodológico, sobretudo os modos de constituição dos sujeitos e os efeitos dos discursos nas formas de conhecer, de ser e de estar no mundo. Ao longo da investigação, as relações de gênero e o sentido de educação foram as questões que mais chamaram atenção nas falas da professora-pesquisadora, que serão tomadas como análise.
Dos indicadores sociais aos analisadores sociais
Authors: Lourau René
Published: April 2021

Capítulo VII (Des indicateurs sociaux aux analyseurs sociaux) do livro L’État-inconscient. Paris: Les Éditions de Minuit, 1978, p. 125 a 138.Tradução: Solange L’Abbate. Revisão: Yvone Greis Notas do trabalho de tradução - As aspas, itálico e palavras no meio do texto iniciadas com letra maiúscula foram mantidos como aparecem no texto original. Há apenas uma nota de rodapé do texto original, que está indicada; as demais foram acrescentadas no decorrer do trabalho de tradução. Ao final, encontra-se uma relação dos autores citados no texto, que foi organizada por doutorandos em Saúde Coletiva da Faculdade de Ciências Médicas da Universidade Estadual de Campinas: Daniel Vannucci Dóbies; Ana Cristina dos Santos Vangrelino; Juliana Dorigan Hespanhol; Lia Bissoli Malaman e Tatiana Loiola.
Editorial
Authors: Santos Adriana Rosa Cruz , Souza Alice De Marchi Pereira de , Rodrigues Heliana De Barros Conde
Published: April 2021

Fazer um resumo
ensaios de um corpo em estado de experiência: a poética da substância do ato
Authors: Santos Adriana Rosa Cruz
Published: April 2021

o presente texto recolhe fragmentos de um percurso de pesquisa de pós-doutorado que toma a errância como dispositivo de abertura do corpo à experiência, ensejando ativar regimes sensíveis e práticas de si-mundo capazes de reencantar o corpo e a vida. A arte de Rosana Paulino e Lygia Clark sopra e ressoa as políticas/poéticas de encantamento e rasga a fina membrana colonial, deflagrando estados de corpo transfigurados pelas intensidades que o interpelam, numa expansão de si que ultrapassa a forma individual e conecta humanos e não-humanos numa única teia viva, como ensinam os indígenas.
Uma experiência de atividade-intervenção: a sensibilidade como ferramenta de luta
Authors: Resende Catarina , Câmara Júlia Virginio , Craveiro Júlia Bodden , Rocha Jully Wanny da Silva , Araújo Luiza S. Loyola de , Freitas Marcelle Da Silva , Ribeiro Mariana Thomaz de Aquino , Guimarães Vic
Published: April 2021

Este trabalho faz uma análise de uma atividade-intervenção proposta pelo grupo de pesquisa CorpoSSutis, suscitada ao encontrar um cenário de retaliação governamental ao ensino nas universidades públicas. Diante desse contexto, e a partir do engajamento da UFF com outras universidades, nossa proposta surgiu em conjunto com uma série de atividades abertas à comunidade. Um grupo de pesquisa que estuda a formação de um corpo-clínico sensível foi sensibilizado pelo fato de boa parte das pesquisas acadêmicas permanecerem enrijecidas quanto ao diálogo com o fora, entre a população e a produção científica e tecnológica universitária. Ao instaurar a pergunta disparadora “Como Sensibilizar os Corpos para Luta?”, a atividade-intervenção em foco pode despertar conversas sobre possíveis relações entre sensibilidade, luta e coletividade.
Saúde mental e arte: espaço de fala para as vozes minoritárias.
Authors: Nogueira Vivian Nunes , Carvalho Damares Moreira de , Araújo Gustavo Henrique Aragão Muniz de , Petrone Rafaela Antunes Fernandes , Valentim Renata Patrícia Forain de
Published: April 2021

O texto procura recuperar a experiência vivida na oficina expressiva “Loucura em Cena: O Teatro do Oprimido como ferramenta na saúde mental para encontrar-se com o estranho que habita dentro de nós”, aplicada por graduandos do curso de Psicologia da UERJ, que procurou compreender os diversos afetos envolvidos na vivência dentro da Universidade. O evento “Políticas/Poéticas do Contágio: ensaios de viver entre muitxs”, realizado no dia 31 de outubro de 2019, foi o cenário para o trabalho da oficina terapêutica, através das técnicas do Teatro do Oprimido, desenvolvido por Augusto Boal. Em cena, a arte pode ser percebida como ferramenta para trabalhar afetos e proporcionar uma melhoria na saúde mental.
A Poética do corpo e sua inteligência pelo percepto e pelo afeto
Authors: Souza Maria Lúcia Galvão
Published: April 2021

Este trabalho tem por finalidade relatar e analisar a atividade desenvolvida na forma de oficina durante o evento de extensão universitária “Políticas/poéticas de contágio: ensaio de viver entre muitxs”, organizado pelo Instituto de Psicologia da UERJ. A Oficina Poética do Corpo teve o intuito de abrir caminhos para o desenvolvimento da consciência de si e do outro, potencializando o ato de criação na forma de vivências práticas, funcionando como uma poética do encontro. Dessa forma, serão relatados os passos para a execução do projeto que culminou em uma rica experiência transdisciplinar na forma de oficina livre, com caráter essencialmente prático, utilizando conceitos relacionados a experiência, corpo, jogo e afeto que foram explanados na forma de ações sensíveis e lúdicas a partir da investigação de narrativas corpóreas, desvelando afetos com alunos de diferentes áreas de conhecimento e de diferentes instituições de ensino.
Experimentações rebeldes e novas estéticas de luta no contemporâneo
Authors: Schubert Fernando Pinheiro , Heckert Ana Lúcia Coelho
Published: April 2021

Este artigo apresenta um recorte das questões debatidas na dissertação de mestrado “Práticas de militância nômade: experimentações rebeldes e novas estéticas de luta no contemporâneo”. Utilizando-se da experiência de um dos autores no processo de luta pela terra dos povos indígenas Tupinikim-Guarani no Estado do Espírito Santo (2005-2010), o texto objetiva analisar a constituição de formas de resistência problematizadoras das relações de poder instituídas na atualidade. O ato de retomada da terra empreendido por essas etnias e os efeitos que se seguiram na produção e articulação de ações rebeldes são debatidos em meio às fissuras que provocaram nos modos de funcionamento político que tecem a máquina administrativa do Estado, bem como dos próprios movimentos sociais. A emergência de dinâmicas e estéticas de luta dissidentes se expressa nos afrontamentos entre redes de insurgência e contra-insurgência, servindo como analisadores de uma sociedade mundial de controle espraiada por todo o tecido social.
No olho do furacão: compreendendo a transição de um Ambulatório de Saúde Mental Infanto-Juvenil para CAPSij à luz da Socioanálise
Authors: Picirilli Cláudia Capelini , Sacardo Daniele Pompei
Published: April 2021

Este artigo origina-se de Pesquisa Intervenção realizada em um município do interior paulista cujo objetivo centrou-se em analisar a transição do modelo de atendimento ambulatorial em saúde mental para o dispositivo de Centro de Atenção Psicossocial Infanto-Juvenil (CAPSij). Utilizou-se a Socioanálise enquanto referencial teórico-metodológico. As demais ferramentas de pesquisa envolveram observação participante; entrevista semiestruturada individual; questionário eletrônico e leitura de livro-ata. Os registros das intervenções socioanalíticas foram construídos em diário de pesquisa. A utilização deste referencial teórico-metodológico, bem como as ferramentas de pesquisa, possibilitaram o reconhecimento dos desafios enfrentados pelos trabalhadores no cotidiano do serviço; analisar as dinâmicas relacionais entre os trabalhadores e as instituições que os inscrevem; identificar as potências de uma equipe que busca resistir à precarização do trabalho; e apontar, para a macrogestão, estratégias que intentem contribuir com esta transição a partir dos princípios da universalidade e da integralidade no cuidado.
Imagens da memória entre Roberto Bolaño e Walter Benjamin
Authors: Ferreira Marcelo Santana
Published: April 2021

O presente artigo é uma problematização da memória a partir do romance Amuleto de Roberto Bolaño, escritor chileno contemporâneo, e da concepção de história materialista em Walter Benjamin, em conexão com uma abordagem política da memória e da subjetividade em psicologia social. O propósito do artigo é defender uma concepção de memória que se relaciona com o tempo histórico decorrido, na articulação de um rastro que merece a atenção do presente. A personagem que ocupa o lugar de narradora no romance de Bolaño enfrenta dificuldades para estabelecer uma narrativa coerente e linear sobre a vivência traumática que experimentou na invasão militar de 1968 na Universidade Nacional Autônoma do México. No entanto, as dificuldades não são impeditivas para o empreendimento de um testemunho, que se subsidia na memória do passado e dos tempos vindouros, expressão do estatuto resistente e sobrevivente da recordação e da tarefa ética da literatura.
Potências monstruosas e ambiguidades sexuais: o caso de Herculine Barbin
Authors: Mação Izabel Rizzi , Alvim Davis Moreira , Bentivoglio Julio César
Published: April 2021

Propõe-se uma abordagem genealógica do problema das ambiguidades sexuais, atentando para as relações de poder/saber que vão, ao longo dos séculos XVIII e XIX, conectando a imagem do monstro ao corpo sexualmente ambíguo. Também recorremos ao conceito de abjeto, indicando sua funcionalidade na formação do sujeito e na instalação da diferença sexual enquanto norma. Ao mesmo tempo, seguimos por pequenas ondulações, tensões e desorientações na composição do sistema sexo/gênero, notadamente aquelas sugeridas no manuscrito “Minhas Memórias”, de Herculine Barbin – uma pessoa intersexual que viveu e escreveu no contexto do século XIX europeu. Com Herculine, avançamos por zonas inóspitas, nas quais nos esbarramos com as potências do monstruoso e do abjeto para desnaturalizar a noção de verdadeiro sexo e, também, a própria concepção ontológica do humano.
Figuras da psicologia francófona do final do século XIX
Authors: Vieira Yuri Pereira Antunes , Ribeiro André Elias Morelli
Published: April 2021

A expressão psicologia francófona designa uma série de saberes e práticas psicológicas que foram desenvolvidas em países cujo idioma principal é o francês, ou por autores que desenvolveram suas ideias neste idioma. Sua conceituação, apesar de bastante ampla, agrupa muitos atores que foram relevantes para a constituição da psicologia no Brasil, através de diversos meios. Contata-se, contudo, que poucos materiais em português foram publicados no Brasil após os anos 1950 sobre vários dos atores da psicologia francófona, de modo que permanecem, em diferentes graus, desconhecidos dos profissionais da psicologia e, muitas vezes, até mesmo dos historiadores. Este trabalho pretende auxiliar no preenchimento desta lacuna ao elaborar biografias de cinco autores francófonos do final do século XIX, importantes para a compreensão da psicologia brasileira: Paul Janet, Théodule Ribot, Henri Beaunis, Alfred Binet e Pierre Janet. Conclui-se que o conceito geral é bastante plural, de modo que as recepções e apropriações destes atores no Brasil ainda estão por ser melhor analisados.
Treating post-renal transplant surgical site infection with combination therapy: a case study
Authors: Hajimohammadi Kazem , Makhdoomi Khadijeh , Zabihi Roghayeh Esmaeili , Parizad Naser
Published: April 2021

Surgical site infection (SSI) is one of the most common and debilitating complications of surgery. The risk of SSI rises if the patient has underlying health-related risk factors. This article reports on the complicated case of 61-year-old female with a history of obesity and diabetes. She was diagnosed with end-stage renal disease (ESRD) and had been receiving haemodialysis since 2012. She underwent a kidney transplant and developed a multidrug-resistant Pseudomonas aeruginosa SSI following surgery. She experienced delayed wound healing with a partially dehisced incision. Despite conventional wound care, there was no progress in wound healing. The authors combined sharp debridement, irrigation and antibiotic therapy with a silver-containing antimicrobial dressing for 1 month. Her SSI improved significantly and she returned to theatre for wound closure. The patient recovered well and was discharged from the hospital after suture removal. Wound care professionals can use combination therapies to manage SSIs effectively and reduce patient and healthcare costs.
Simulation and student learning: will NMC policy lead to lasting change?
Authors: Glasper Alan
Published: April 2021

Emeritus Professor Alan Glasper, from the University of Southampton, discusses a new initiative from the Nursing and Midwifery Council to increase clinical learning through simulation during the COVID-19 pandemic
Vascular access device securement for oncology patients and those with chronic diseases
Authors: Hawes Michelle L
Published: April 2021

This article presents three case studies, each discussing securement issues as they relate to the use of long-term vascular access devices from the perspectives of the clinician and the patient. The choice of securement should be weighed against the patient's activity level, duration of the line placement, infection risks and inevitable skin irritation caused by repeated replacement of adhesive securement. Living with a chronic illness requiring frequent infusions is difficult enough—worrying about the device being dislodged should not be an additional stressor.
Research roundup: April 2021
Authors: Odd Dawn , Poole Patricia
Published: April 2021

In this section, a range of brief synopses of recently published articles that may be of interest to health visitors is presented. The aim of this roundup is to give an overview, rather than a detailed summary, of the research papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided
Recruitment and retention of participants in longitudinal studies after a natural disaster
Authors: McLeod Geraldine F.H. , Horwood L. John , Darlow Brian A. , Boden Joseph M. , Martin Julia , Spittlehouse Janet K. , Carter Frances A. , Jordan Jennifer , Porter Richard , Bell Caroline , Douglas Katie , Henderson Jacki , Goulden Marie , McIntosh Virginia V.W. , Woodward Lianne J. , Rucklidge Julia J. , Kuijer Roeline G. , Allen Joanne , Vierck Esther
Published: April 2021

Climate change and population growth will increase vulnerability to natural and human-made disasters or pandemics. Longitudinal research studies may be adversely impacted by a lack of access to study resources, inability to travel around the urban environment, reluctance of sample members to attend appointments, sample members moving residence and potentially also the destruction of research facilities. One of the key advantages of longitudinal research is the ability to assess associations between exposures and outcomes by limiting the influence of sample selection bias. However, ensuring the validity and reliability of findings in longitudinal research requires the recruitment and retention of respondents who are willing and able to be repeatedly assessed over an extended period of time. This study examined recruitment and retention strategies of 11 longitudinal cohort studies operating during the Christchurch, New Zealand earthquake sequence which began in September 2010, including staff perceptions of the major impediments to study operations during/after the earthquakes and respondents’ barriers to participation. Successful strategies to assist recruitment and retention after a natural disaster are discussed. With the current COVID-19 pandemic, longitudinal studies are potentially encountering some of the issues highlighted in this paper including: closure of facilities, restricted movement of research staff and sample members, and reluctance of sample members to attend appointments. It is possible that suggestions in this paper may be implemented so that longitudinal studies can protect the operation of their research programmes.
Single-objective high-resolution confocal light sheet fluorescence microscopy for standard biological sample geometries
Authors: Yordanov Stoyan , Neuhaus Konstantin , Hartmann Raimo , Díaz-Pascual Francisco , Vidakovic Lucia , Singh Praveen K. , Drescher Knut
Published: April 2021

Three-dimensional fluorescence-based imaging of living cells and organisms requires the sample to be exposed to substantial excitation illumination energy, typically causing phototoxicity and photobleaching. Light sheet fluorescence microscopy dramatically reduces phototoxicity, yet most implementations are limited to objective lenses with low numerical aperture and particular sample geometries that are built for specific biological systems. To overcome these limitations, we developed a single-objective light sheet fluorescence system for biological imaging based on axial plane optical microscopy and digital confocal slit detection, using either Bessel or Gaussian beam shapes. Compared to spinning disk confocal microscopy, this system displays similar optical resolution, but a significantly reduced photobleaching at the same signal level. This single-objective light sheet technique is built as an add-on module for standard research microscopes and the technique is compatible with high-numerical aperture oil immersion objectives and standard samples mounted on coverslips. We demonstrate the performance of this technique by imaging three-dimensional dynamic processes, including bacterial biofilm dispersal, the response of biofilms to osmotic shocks, and macrophage phagocytosis of bacterial cells.
Kerr-lens mode-locked Yb:LuAG ceramic thin-disk laser
Authors: Kitajima Shotaro , Shirakawa Akira , Yagi Hideki , Yanagitani Takagimi
Published: April 2021

A Kerr-lens mode-locked (KLM) thin-disk laser with Yb:LuAG ceramic was demonstrated. Yb:LuAG ceramic is an attractive material for high-power lasers due to its high thermal conductivity and large emission cross section. The highest output power of 17 W with a pulse duration of 130 fs was achieved. Moreover, the pulse duration of 88 fs was also obtained with a high-Q factor cavity. To the best of our knowledge, this is the first demonstration of a KLM thin-disk laser based on Yb:LuAG, including both ceramic and single crystal. The results show the usefulness of ceramic thin disks for high-power ultrashort pulse laser sources.
Obesity under full fresh fruit and vegetable access conditions
Authors: Silva Andres , Jano Pilar , Von Hausen Nicolás
Published: April 2021

There is no agreement regarding the role of fresh fruit and vegetables’ affordability, accessibility and availability, or access in general, on obesity rates. In this article we investigated whether access to fresh fruit and vegetables is related to better biometric indicators such as weight and body mass index. Using mediation and matching methods and assuming that farmers and traditional market sellers have easy access to fruit and vegetables, we found that having better access is not associated to a reduction in weight or body mass index. Potential explanations for this result are that better access was not associated with fresh fruit and vegetables’ consumption and fruit and vegetables’ consumption was not associated with weight and body mass index. Also, fresh fruit and vegetables’ sellers had a higher weight and body mass index compared to the rest of the population but, a similar weight and body mass index compared to people with their same educational level. Therefore, variations on weight and body mass index were more associated with educational level rather than with access. Access may not be the single story to explain fruit and vegetable consumption.