bluuebunny/crossref_metadata_2025 huggingface dataset:
GoFood Vs ShopeeFood: Manakah yang Menjadi Pilihan Generasi Z?
Authors: Faizah Fita Nurotul , Zulfaturrohmaniyah Zulfaturrohmaniyah
Published: May 2023

This study tries to ascertain Generation Z's preference for online food delivery between ShopeeFood and GoFood based on the notion of the marketing mix from an Islamic economics perspective. A comparative descriptive methodology was adopted. The research participants at the time were Generation Z from Semarang City. About the sample that was obtained through accidental sampling under non-probability sampling. While research data was gathered from observations, questionnaires, observations, interviews, and documentation. According to the findings, Generation Z prefers ShopeeFood over GoFood. From a sharia economic perspective, this can be seen in the 7P marketing mix, which includes: pragmatism & product aspects, which explain that even though there are more GoFood merchants, Generation Z prefers ShopeeFood because the necessary menu options are also available in the market, while the pertinence & promotion aspect, which explains ShopeeFood offers more promos even though it claims the promo is easier on GoFood, and the palliation & price aspect, where Shop The results are not significantly different for the factors of persistence and process, patience and environment, peer support and people, pedagogy and environment, and so on.
Panic Buying as a Cause of Inflation According to al-Maqrizi's Perspective
Authors: Dahliana Difi
Published: May 2023

This article was written based on the results of qualitative literature research which aims to determine the impact of panic buying in March 2020 on the inflation rate in Indonesia and to classify panic buying as the cause of inflation based on al-Maqrizi's perspective. The background of this research is because there are only a few studies on panic buying in Islamic economic discourse that can be found when browsing in Google Scholar page, even though panic buying at that period was a problem in various countries. The results of this study are: 1) the panic buying that occurred in Indonesia was not severe, so it does not have an impact on the inflation rate; 2) according to al-Maqrizi’s perspective, panic buying can be classified into human error inflation.
COVID-19 dan Pasar Modal Syariah: Pendekatan Regresi Korelasi Kanonikal
Authors: Octaviana Ratna
Published: May 2023

Economic activity in 2019–2020 were heavily impacted by the COVID-19 pandemic sickness. The effect of COVID-19 on investments made on Islamic financial markets, however, has not been studied in research. The primary focus of this study will be on the connection between the Covid-19 movement and the Islamic financial market industry. In the quantitative method, canonical correlation analysis was used. Samples were collected from March 3 through August. The movement of the Jakarta Islamic Index and the Covid-19 Movement variable are used to examine Sharia Mutual Funds and Sukuk. The results show that neither of the two dependent variables—the Jakarta Islamic Index nor Sukuk—is significantly impacted by the movement of Covid-19. But, there is one factor on which Islamic mutual funds have a positive and significant influence.
Kemampuan Guru Penggerak dalam Program Merdeka Belajar di Daerah Jember
Authors: Fitriyah Chumi Zahroul , Wardani Rizki Putri , Rofiq Annur
Published: May 2023

Guru Penggerak is one of the independent learning programs that is expected to increase teacher competence with several programs and encourage learning independence for students. The purpose of this study is to identify the ability of Guru Penggerak in implementing independent learning classes. This type of research is a qualitative research with an interview, field survey, and observation approach. Data analysis using data reduction, data triangulation, and data synthesis. The results of the study show that teachers have sufficient professional competence in the ability of teachers to drive independent learning.
Prediction of Surface Wellhead Deformation Via Calculation of Tubular Growth Due to Thermal Effects
Authors: Proano Manuel Alejandro , Meneses Alba Rolanda , Tates Victor Andres , Aponte Jesus , Magalhaes Tasso , Duque Gerardo Javier
Published: May 2023

After implementing a water injection project with high temperature (up to 235°F @ surface) sourced water in existing wells, 63% of the conventional Wellhead associated with waterflooding installed showed growth/inclination at the surface. A detailed analysis of twenty-seven wells in the Orient Basin of Ecuador was performed, where onsite measurements and engineering calculations of the loads and elongations of the production casing and tubing strings were caused by thermal effects.

A specialized tubular modeling software was used to simulate the water producer wells and injector well thermal profiles, casing elongation, and buckling. The produced water has temperatures superior to 200°F and is transferred directly to the injector wells without any allowed time to cool down. The analysis focused mainly on the 9-5/8″ production casing since it is not cemented to the surface and has almost 6,000ft of free pipe able to elongate due to high-temperature injected water. As the other casing strings were cemented to the surface, it was assumed that they were adequately anchored, and no elongation would occur.

All the wells were inspected before entering service, and no wellhead deformation was observed. Once operations started, the surface temperatures reached up to 235°F on the water producers and injectors. After six months, the production operators noticed the first signs of wellhead movement, with consequent inclination. A survey was carried out in 27 wells, where the wellhead deformations were measured by taking the projection in 3 planes (X, Y, and Z). Out of 27 wells surveyed, two water producers presented an inclination above 2° and one injector well above 1.5°, which was deemed excessive. It was possible to establish a good correlation between the specialized tubular modeling software results and the deformations measured at the surface, enabling the development of guidelines to define if high-temperature wellheads with expansion capabilities would be required.

It also evaluated the possibility of using insulated packer fluids to minimize heat transfer and production casing elongation. The simulation estimated an average elongation reduction of 28% and 41% when water-based and oil-based packer fluids are used, respectively.

This work created a workflow to identify wells with a high risk of suffering wellhead deformation caused by high surface temperature. Combining the simulation results with the field measurements made it possible to determine when deformation at the surface was expected and high-temperature wellheads with expansion capabilities were needed. It also evaluated the effectiveness of insulated packer fluids in reducing the casing elongation and avoiding the installation of such wellheads.
The Impacts of Gas Adsorption on the Productivity of Marcellus Shale Horizontal Well
Authors: Bulule Valcia , Sattari Arya , Aminian Kashy , El Sgher Mohamed , Samuel Ameri
Published: May 2023

The shale formations, in addition to the gas present in the pores of the rock, contain gas in the adsorbed state in the organic matter within the rock. As the pressure depletes in the reservoir the adsorbed gas is released and augments the gas production. In addition, gas desorption can potentially lead to permeability enhancement due to shale matrix shrinkage. At the same time, the pressure depletion increases the effective stress causing shale permeability and hydraulic fracture conductivity impairments. The purpose of this study was to investigate the impact of the gas desorption on the productivity of Marcellus shale horizontal well with multiple hydraulic fracture stages. The impacts of hydraulic fracture properties including half-length, conductivity, and stage spacing on gas desorption were also investigated.

To investigate the impact of the gas desorption on gas production from Marcellus shale, a reservoir model for a horizontal well completed with multiple hydraulic fracture stages was used. The model has been developed based on the available information from several existing Marcellus shale horizontal wells in West Virginia. The laboratory and published data relative to adsorbed gas and the geomechanical factors were analyzed and geomechanical multipliers were generated and incorporated in the model. The geomechanical multipliers account for the impairments in hydraulic fracture conductivity and the reduction in the formation (matrix and fissure) permeability as well as the shale shrinkage caused by the reservoir depletion. The model was then utilized to investigate the impact of different parameters including Langmuir pressure and volume, fracture half-lengths, fracture spacings, and fracture conductivity on gas desorption and gas production. The inclusion of geomechanical multipliers provided more realistic production predictions and better understanding of the desorbed gas impact. The gas desorption was found to have a significant impact on the productivity during later stages of the production. This is contributed to pressure depletion required for desorption to become significant. The contribution of the desorbed gas to production increases as the fracture half-length increases and the fracture spacing decreases. Therefore, it can be concluded that desorption of gas depends on the stimulated reservoir volume.
Systematic Evaluation of Alternative Acid System for High-Temperature Carbonate Formation
Authors: Gajipara Riten Prafulbhai , Hill A. D. , Zhu Ding , AlNajjar Najim , Chkolny Nikita , Weissenberger Markus
Published: May 2023

Alternative acid systems for carbonate acidizing have been developed to overcome some weaknesses of conventionally used hydrochloric acid. Such systems are of particular interest for the reservoirs with high temperature because of high reactivity and corrosiveness of HCl at temperatures above 200°F. The main advantages of the evaluated alternative acid include better wormhole efficiency at lower injection rates and less corrosiveness to protect tubulars and surface equipment. In a high-temperature environment, the performance of alternative acids needs to be evaluated for the feasibility of being an effective stimulation fluid. Even though there are plenty of core flood data in the literature for carbonate rocks, there are fewer studies/publications that provide acid performance at high temperatures. In this paper, we present an experimental study of an alternative acid over a wide range of temperatures up to 300°F. The goal is to confirm the applicability and identify the optimal conditions for field operations. We conducted core flood tests using the alternative acid to generate wormhole efficiency curves with different interstitial velocities. The optimal condition was determined from the experimental results for each temperature tested. The temperature for testing ranged from 125°F to 300°F. The tested acid system created a preferred wormhole structure with a dominant wormhole for all test conditions. This indicates that the alternative acid system can be used as a matrix acidizing fluid for carbonate reservoirs over a broad range of temperatures up to 300°F. As observed by HCl core flood tests, wormhole efficiency for the alternative acid also decreases with increasing temperature when compared with its performance at low temperature, but it showed reasonable results of wormholing, while HCl experiments was not practical at 300°F. The challenge of stimulating high-temperature formations can be addressed when the acid system and injection condition are designed correctly. The data presented in this paper add new information for high-temperature acid core flood testing, and provide useful information for matrix acidizing design using alternative acid systems.
Ensemble Machine Learning for Data-Driven Predictive Analytics of Drilling Rate of Penetration (ROP) Modeling: A Case Study in a Southern Iraqi Oil Field
Authors: Al-Sahlanee Dhuha T. , Allawi Raed H. , Al-Mudhafar Watheq J. , Yao Changqing
Published: May 2023

Modeling the drill bit Rate of Penetration (ROP) is crucial for optimizing drilling operations as maximum ROP causes fast drilling, reflecting efficient rig performance and productivity. In this paper, four Ensemble machine learning (ML) algorithms were adopted to reconstruct ROP predictive models: Random Forest (RF), Gradient Boosting (GB), Extreme Gradient Boost (XGB), and Adaptive Boosting (AdaBoost). The research was implemented on well data for the entire stratigraphy column in a giant Southern Iraqi oil field. The drilling operations in the oil field pass through 19 formations (including 4 oil-bearing reservoirs) from Dibdibba to Zubair in a total depth of approximately 3200 m. From the stratigraphic column, various lithology types exist, such as carbonate and clastic with distinct thicknesses that range from (40-440) m. The ROP predictive models were built given 14 operating parameters: Total Vertical Depth (TVD), Weight on Bit (WOB), Rotation per Minute (RPM), Torque, Total RPM, flow rate, Standpipe Pressure (SPP), effective density, bit size, D exponent, Gamma Ray (GR), density, neutron, and caliper, and the discrete lithology distribution. For ROP modeling and validation, a dataset that combines information from three development wells was collected, randomly subsampled, and then subdivided into 85% for training and 15% for validation and testing. The root means square prediction error (RMSE) and coefficient of correlation (R-sq) were used as statistical mismatch quantification tools between the measured and predicted ROP given the test subset. Except for Adaboost, all the other three ML approaches have given acceptable accurate ROP predictions with good matching between the ROP to the measured and predicted for the testing subset in addition to the prediction for each well across the entire depth. This integrated modeling workflow with cross-validation of combining three wells together has resulted in more accurate prediction than using one well as a reference for prediction. In the ROP optimization, determining the optimal set of the 14 operational parameters leads to the fastest penetration rate and most economic drilling. The presented workflow is not only predicting the proper penetration rate but also optimizing the drilling parameters and reducing the drilling cost of future wells. Additionally, the resulting ROP ML-predictive models can be implemented for the prediction of the drilling rate of penetration in other areas of this oil field and also other nearby fields of the similar stratigraphic columns.
Towards Improved Risk Assessment and Accident Investigation
Authors: Duhon Howard , Ariamuthu Venkidasalapathy Joshiba , Kalantri Pranav
Published: May 2023

Risk assessments are an important part of HAZOPs, root cause analysis studies, and other process safety evaluations. But process risk assessments, as typically performed, suffer from several identifiable and fixable flaws. These include: The assumption that accidents have a root cause, such as a component failure or human error,Ambiguous risk matrices that yield questionable and non-repeatable results,Flawed concepts of how people in the ‘line of fire’ make decisions.

Failure to identify/acknowledge common failure modes when they exist at a hierarchical level above the component level.

This paper addresses all these flaws and suggests solutions. The solutions are based on several schools of thought, including: Nancy Leveson's System Theoretic Accident Model and Processes (STAMP)Gary Klein's work on Naturalistic Decision Making (NDM)James Reasons’ work on human error,Level of Protection Analysis (LOPA) and Safety Integrity Level (SIL)Complexity science and Hierarchy Theory

Three cases studies are used to illustrate the implications of these flaws in practice and the power of improved approaches. Evaluation of a root cause analysis (conducted by others) of a fatal accident involving loss of containment of sour water.Comparison of the use of a typical color-coded risk matrix vs. LOPA-based risk matrix for process risk assessment.A risk assessment study used to determine which valves on a sour gas platform should be locked open or locked closed.
Operational Theory and Qualification of a Unique Autonomous Inflow Control Device for First Use in a Heavy Oil Layered Reservoir
Authors: Yao Xiutian , Xu Lei , Wang Chao , Simonds Floyd , Ding Bing , Zhao Liang
Published: May 2023

As Operators face challenges due to increased water production worldwide the application of Passive and Autonomous Inflow Control Devices has proven effective at both delaying water production onset (passive functionality) and reducing water production at the surface (autonomous functionality). Passive technology has been deployed very effectively in hundreds of wells while autonomous devices are showing great promise to reduce costs, environmental risk, and potentially a significant reduction in topside infrastructure.

Passive devices only delay the onset of unwanted fluid breakthrough. Once breakthrough occurs, these tools do not restrict production. This led to the development of AICD technology which provides passive functionality initially but restricts water production at breakthrough. This functionality is greatly enhanced when compartments are created downhole to enable a "network" of devices to function independently at breakthrough, allowing other compartments to produce oil relatively unrestricted. The design proposed in this paper uses no moving parts, significantly restricts water production in a wide range of crude viscosities, is easily configured for a variety of downhole conditions, and delivers passive ICD performance with AICD benefits using a simple, reliable, and unique design.

The tool functions to restrict water production progressively as either oil viscosity or water cut increase without ever completely or nearly completely closing to production, which makes it an excellent solution for marginal production wells, younger reservoirs, and wells with lower overall production rates compared to other technologies.

The paper will discuss the theory of the device's functionality to differentiate between fluids present. Laboratory test results will be shown to demonstrate flow performance as well as API 19ICD[1] testing for erosion, plugging resistance, and mud flow initiation testing. The completion modeling process will be discussed in detail for an upcoming completion in Sinopec's Shengli Field.
Managing the terror of publication bias: A comprehensive p-curve analysis of the Terror Management Theory literature
Authors: Chen Lihan , Benjamin Rachele , Guo Yingchi , Lai Addison , Heine Steven J.
Published: May 2023

We assessed the evidential value of the large literature (k=826 studies) investigating the mortality salience (MS) hypothesis from terror management theory. We employed a multitool assessment approach and reviewed past efforts to replicate experiments testing the MS hypothesis, and conducted a p-curve, a z-curve, and a random effects meta-analysis including bias corrections of the selection model, PET-PEESE, and WAAP-WLS on the studies. Overall, the different meta-analytic tools pointed to conflicting conclusions, reflecting differences in the methodology and philosophy of these tools. Our synthesis of these findings suggests there are true effects underlying some studies of the MS hypothesis, although the effects are highly heterogeneous, and the majority of studies are underpowered. We recommend future replications to assume a smaller effect size (r = .10 ~ .15) and to follow expert guidance in the experimental protocol. Given the conflicting findings that emerged, we suggest that future attempts to evaluate other literatures would benefit from a multitool assessment approach.
Transposons are important contributors to gene expression variability under selection in rice populations
Authors: Castanera Raul , Morales-Díaz Noemia , Gupta Sonal , Purugganan Michael , Casacuberta Josep
Published: May 2023

Transposable elements are an important source of genome variability. Here, we analyze their contribution to gene expression variability in rice by performing a TE insertion polymorphism (TIP)-eQTL mapping using expression data from 208 varieties from the O. sativa ssp. indica and O. sativa ssp. japonica subspecies. Our data shows that TE insertions are associated with changes of expression of many genes known to be targets of rice domestication and breeding. An important fraction of these insertions were already present in the rice wild ancestors, and have been differentially selected in indica and japonica rice populations. Taken together, our results show that small changes of expression in signal transduction genes induced by TE insertions accompany the domestication and adaptation of rice populations.
Application of Multi-Objective Optimization and Graph Theory Algorithms to Achieve Efficient and Adaptable Partitioning of District Metered Areas in Water Distribution Networks
Authors: Shekofteh Mohammad Reza , Yousefi-Khoshqalb Ehsan , Piratla Kalyan
Published: May 2023

The management of network infrastructure in the context of water sector sustainability poses a significant challenge due to the increasing demand for fresh water, rapid infrastructure deterioration, and rising global water shortages. This paper presents a practical method to address these challenges by partitioning water distribution networks (WDNs) into district metered areas (DMAs) during critical hydraulic conditions to ensure adequate water supply, appropriate pressure and flow rates, and improved customer satisfaction. The proposed method employs efficient graph theoretic algorithms and a multi-objective optimization approach to reduce computational effort and determine the optimal dynamic layout of DMAs based on flow meters and gate valves, while minimizing variable installation costs and regulating water loss monitoring and management. The method ensures that only the number of flowmeters and gate valves may require modification, rather than the DMA layout, as hydraulic criteria may frequently change for a network due to various reasons. The effectiveness of the proposed method is demonstrated through successful implementation on six complex WDNs consisting of hundreds of pipes and nodes.
Diverse Amdoparvoviruses Infecting Farmed Asian Badgers (Meles meles)
Authors: Wu Yanhong , Zhao Yongqiang , Zhang Xiuting , Wei Tao , Peng Qianwen , Wang Jianke , Liu Zongyue , Zhu Yanzhu , Shao Xiqun
Published: May 2023

Amdoparvoviruses infect various carnivores, including mustelids, canids and felids et al. Aleutian mink disease virus (AMDV), Carnivore amdoparvovirus 1, infects mink and other Mustelidae and causes subclinical diseases or fatal chronic immune stimulation and immune complex diseases. Here, we identified a nearly complete genome (4265nt) of a novel amdoparvovirus from farmed Asian badgers (Meles meles) and tentatively named Meles meles amdoparvovirus (MMAV). Furthermore, we constructed phylogenetic trees based on the NS1 and VP2 proteins, respectively, as well as the amdoparvoviral VP2 nucleotide hypervariable region. MMAV NS1 protein shared 62.6%-88.8% sequence identities with other known amdoparvoviruses and phylogenetically clustered into a unique clade, while VP2 protein shared 76.7%-97.2% identities and clustered into two clades, of which one was more closely related to raccoon dog and arctic fox amdoparvovirus (RFAV), and the other clade is independent of other known amdoparvoviruses. According to the NS1 genetic distance-based criteria, MMAV is classified as a novel species of Amdoparvovirus. the positive rate for amdoparvovirus by PCR was 32.8% (47/143) in 143 clinical samples collected from 134 individual badgers. MMAV DNA was detected in feces, blood, spleen, liver, lung, and adipose tissue from Asian badgers. Eight isolates were sequenced from eight samples, with five obtaining approximate complete genomes. Six serum samples were PCR,CIEP and IAT-positive, with four having high serum antibody titers (＞512) against AMDV-G. Twenty-six of the 41 amdoparvovirus-positive badgers exhibited diseased symptoms, and some necropsy revealed organic lesions. Therefore, these lines of evidence suggested that we discovered novel and diverse amdoparvoviruses, MMAVs, that naturally infect Asian badgers of mustelid and may be cause Aleutian disease in badgers similar to that seen in mink. Furthermore, our findings supported that mustelid species are susceptible to diverse amdoparvoviruses and the molecular characteristics of amdoparvorviruses divergence between hosts species.
PATTERN OF BODY FAT DISTRIBUTION IN PATIENTS OF PCOS USING DEXA BASED INDICES
Authors: Birjees Sanna
Published: May 2023

Background: considering the close link between polycystic ovary syndrome (PCOS) and metabolic syndrome considerable research has been devoted to study the pattern of fat distribution in PCOS.
Objectives: The study is aimed to assess usefulness of dual energy X-Ray absorptiometry (DEXA) based regional fat distribution indices as predictor of development of PCOS.
Methods: This cross sectional study recruited diagnosed cases of PCOS using Rotterdam Criteria (cases n=86) and healthy age matched controls (n=90). DEXA was performed in both the groups for assessment of total and regional body fat distribution after undergoing ultrasonography (USG) and baseline/biochemical evaluation.
Results: the study revealed significant difference between cases and controls in trunk fat percentage (40.2 % ± 9.1% vs 26.5%±9.1%; p < 0.001) , android fat percentage (42.4%±41%vs 27.8%±1.51%; p<0.001), total fat percentage (43.8%±8% vs28.5%±1.6%;p<0.001), Fat Mass/Ht2 (fat mass index)( 8.82±3%vs4.8±1.7%;p<0.001), Android/Gynoid ratio(1.05±0.1vs0.7±0.2; p<0.001), trunk/limb fat mass ratio(1.06±0.3vs0.69±0.3;p,0.001).Multivariate analysis revealed significant relation of trunk fat mass with android % fat, Gynoid fat mass, and android-gynoid ratio.
Conclusions: the study demonstrates that there is central pattern of fat distribution in patients with PCOS while the overall fat might not be increased which is well analyzed by DEXA. Hence, we suggest its use in initial diagnostic work up and follow up of PCOS patients for their body fat distribution and content.
Vacuum sealing drainage to treat Fournier’s gangrene
Authors: Chen Ju-hua , Li Yu-bo , Li De-gang , Zeng Xiao-mei , Yao Qiu-yuan , Fu Jun , Wang Gong-he , Huang Xiao-yan
Published: May 2023

Background Vacuum sealing drainage (VSD) is widely applied in complex wound repair. We aimed to compare traditional debridement and drainage and VSD in treating Fournier's gangrene (FG).Methods Data of patients surgically treated for FG were retrospectively analyzed.Results Of the 36 patients (men: 31, women: 5; mean age: 53.5 ± 11.3 [range: 28–74] years) included in the study, no patients died. Between-group differences regarding sex, age, BMI, time from first debridement to wound healing, number of debridements, FGSI, and shock were not statistically significant (P > 0.05). However, lesion diameter, colostomy, VAS score, dressing changes, analgesic use, length of hospital stay, and wound reconstruction method (χ2 = 5.43, P = 0.04) exhibited statistically significant differences. Tension-relieving sutures (6 vs. 21) and flap transfer (4 vs. 2) were applied in Groups I and II, respectively.Conclusion VSD can reduce postoperative dressing changes and analgesic use, and shrunk the wound area, thereby reducing flap transfer in wound reconstruction.
Prevention of the Adverse Effects of Neoadjuvant Chemotherapy for Esophageal Cancer: Role of Nutritional Management in Different Neoadjuvant Chemotherapy Regimens
Authors: Onishi Sachiyo , Tajika Masahiro , Tanaka Tsutomu , Yamada Keisaku , Inaba Yoshitaka , Abe Tetsuya , Muro Kei , Shimizu Masahito , Niwa Yasumasa
Published: May 2023

Based on the results of the JCOG1109 trial, docetaxel + cisplatin + 5-fluorouracil (DCF) may be a standard neoadjuvant chemotherapy (NAC), in addition to the conventional 5-fluorouracil and cisplatin (FP) therapy. We examined whether the nutritional therapy should be modified when a different NAC is used based on the changes in body composition. The study included 215 patients with advanced esophageal cancer who underwent surgery after receiving NAC at our hospital between 2013 and 2019, and those who underwent abdominal computed tomography before and after NAC. The skeletal muscle mass index (SMI) was calculated using the following formula: total skeletal muscle mass at the third lumbar level/height2. The visceral and subcutaneous fat masses were assessed at the umbilical level. The lower 25% of men and women were defined as the low visceral fat and low subcutaneous fat groups, respectively. The DCF group was significantly younger (p < 0.01), had higher proportion of men (p = 0.03), and had higher proportion of patients with cStage III disease (p < 0.01) compared with the FP group. The body composition changes were not significantly different in terms of percentage changes in SMI and visceral fat mass. Multivariate analysis showed that cStage III disease and a shift to low visceral fat were prognostic factors, whereas differences in NAC were not. Although no significant difference was found in the body composition before and after NAC, aggressive nutritional management is recommended during NAC, especially because a shift to a low visceral fat affects the patient’s prognosis.
Primary care delivery of behavioral weight loss services for adults with cardiovascular risk factors: development of pragmatic implementation strategies and results of a randomized feasibility trial
Authors: Ackermann Ronald T , Cameron Kenzie , Liss David , Dolan Nancy , Aikman Cassandra , Carson Amy , Harris Sterling , Doyle Kathryn , Cooper Andrew , Hitsman Brian
Published: May 2023

Background Intensive lifestyle interventions (ILI) improve weight loss and cardiovascular risk factors, but health systems face challenges implementing them. We engaged stakeholders to cocreate and evaluate feasibility of primary care implementation strategies and of a pragmatic randomization procedure to be used for a future effectiveness trial.Methods The study setting was a single, urban primary care office. Patients with BMI ≥ 27 and ≥ 1 cardiovascular risk factor were sent a single electronic health record (EHR) message between December 2019 and January 2020 offering services to support an initial weight loss goal of about “10 pounds in 10 weeks.” All patients who affirmed weight loss interest were pragmatically enrolled in the trial and offered “Basic Lifestyle Services” (BLS), including a scale that transmits weight data to the EHR using cellular networks, a coupon to enroll in lifestyle coaching resources through a partnering fitness organization, and periodic EHR messages encouraging use of these resources. About half (n = 42) of participants were randomized by an automated EHR algorithm to also receive “Customized Lifestyle Services” (CLS), including weekly email messages adapted to individual weight loss progress and telephonic coaching by a nurse for those facing challenges. Interventions and assessments spanned January to July 2020, with interference by the coronavirus pandemic. Weight measures were collected from administrative sources. Qualitative analysis of stakeholder recommendations and patient interviews assessed acceptability, appropriateness, and sustainability of intervention components.Results Over 6 weeks, 426 patients were sent the EHR invitation message and 80 (18.8%) affirmed interest in the weight loss goal and were included for analysis. EHR data were available to ascertain a 6-month weight value for 77 (96%) patients. Overall, 62% of participants lost weight; 15.0% exhibited weight loss ≥ 5%, with no statistically significant difference between CLS or BLS arms (p = 0.85). CLS assignment increased participation in daily self-weighing (43% versus 21% of patients through 12 weeks) and enrollment in referral-based lifestyle support resources (52% versus 37%).Conclusions This preliminary study demonstrates feasibility of implementation strategies for primary care offices to offer and coordinate ILI core components, as well as a pragmatic randomization procedure for use in a future randomized comparative trial.
One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression
Authors: Sasaki Masato , Yamamoto Kazuo , Ueda Takeshi , Irokawa Hayato , Takeda Kouki , Sekine Ryoya , Ito Fumie , Tanaka Yutaka , Kuge Shusuke , Shibata Nobuyuki
Published: May 2023

Tumor cells generally require large amounts of nucleotides, and thus activate de novo purine synthesis (dnPS). In the dnPS reactions, 10-formyltetrahydorofolate (10-fTHF) supplied by one-carbon metabolism is utilized as a formyl group donor. We focused on aldehyde dehydrogenase 1 family member L1 (ALDH1L1), which metabolizes 10-fTHF to tetrahydrofolate (THF) and whose expression is often attenuated in hepatocellular carcinoma (HCC). We generated ALDH1L1-expressing HuH-7 cells to perform metabolome analysis and found that intracellular levels of serine were reduced and glycine was increased. In addition, 5-aminoimidazole-4-carboxamide ribonucleotide (ZMP), a dnPS intermediate, accumulated due to the consumption of 10-fTHF by ALDH1L1, which inhibited ZMP formylation. Importantly, ALDH1L1-expressing cells showed reduced ZMP sensitivity and higher mitochondrial activity. The suppression of mitochondrial serine catabolism by ALDH1L1 expression was speculated to be closely related to this phenotype. Gene set enrichment analysis utilizing The Cancer Genome Atlas (TCGA) data revealed that genes related to oxidative phosphorylation were enriched in HCC patients with high ALDH1L1 expression. Moreover, drug sensitivity data analysis demonstrated that HCC cell lines with low expression of ALDH1L1 were sensitive to ZMP and cordycepin, a structural analog of ZMP and AMP. Our study revealed that ZMP and AMP analogs might be effective in the pharmacotherapy of HCC patients with low expression of ALDH1L1.
A case of dipeptidyl peptidase 4 inhibitor-related glomerulopathy combined with renal cancer diagnosed incidentally by percutaneous kidney biopsy
Authors: Kurihara Shigekazu , Sawa Naoki , Sumida Keiichi , Ikuma¹ Daisuke , Oba¹ Yuki , Mizuno Hiroki , Sekine Akinari , Yamanouchi Masayuki , Hasegawa Eiko , Suwabe Tatsuya , Urakami Shinji , Kono Kei , Kinowaki Keiichi , Ohashi Kenichi , Yamaguchi Yutaka , Ubara Yoshifumi
Published: May 2023

Kidney biopsy was performed in a 64-year-old woman with type 2 diabetes, less than 1 g of proteinuria, who rapidly progressed to end-stage renal failure within about 2 years. At biopsy, a renal cell carcinoma, 8 mm in size, was diagnosed; the tumor was not evident on computed tomography performed before biopsy. The non-cancerous area was characterized by a high degree of thrombotic microangiopathy (TMA)-like endothelial cell damage. The clinical course of the patient showed that renal function deteriorated progressively after the use of two dipeptidyl peptidase 4 (DPP-4) inhibitors. A TMA-like lesion associated with DPP4 inhibitor administration may have contributed to the rapid decline in renal function.
First records of two new silverfish species (Ctenolepisma longicaudatum and Ctenolepisma calvum) in Slovakia, with checklist and identification key of Slovak Zygentoma
Authors: Bednar Frantisek , Hemala Vladimír , Čejka Tomáš
Published: May 2023

In recent years, synanthropic species of the genus Zygentoma (especially Ctenolepisma longicaudatum and C. calvum) have begun to spread in central Europe, with the introduction of these and other species across the continent. Two above-mentioned non-native species of silverfish have also recently been confirmed in Slovakia. This paper aims to comment on the occurrence of the two non-native species in Slovakia, to compile an identification key for all (i.e. also native) Slovak silverfish species and establish local species names.
A first-generation genome-wide map of correlated DNA methylation demonstrates highly coordinated and tissue-independent clustering across regulatory regions
Authors: Jajoo Aarti , Hirschi Owen , Schulze Katharina , Guan Yongtao , Hanchard Neil
Published: May 2023

Genome-wide DNA methylation studies have typically focused on quantitative assessments of CpG methylation at individual loci. Although methylation states at nearby CpG sites are known to be highly correlated, suggestive of an underlying coordinated regulatory network, the extent and consistency of inter-CpG methylation correlation across the genome, including variation between individuals, disease states, and tissues, remains unknown. Here, we leverage image conversion of correlation matrices to identify correlated methylation units (CMUs) across the genome, describe their variation across tissues, and annotate their regulatory potential using 35 public Illumina BeadChip datasets spanning more than 12,000 individuals and 26 different tissues. We identified a median of 18,125 CMUs genome-wide, occurring on all chromosomes and spanning a median of ~1 kb. Notably, 50% of CMUs had evidence of long-range correlation with other proximal CMUs. Although the size and number of CMUs varied across datasets, we observed strong intra-tissue consistency among CMUs, with those in testis encompassing those seen in most other tissues. Approximately 20% of CMUs were highly conserved across normal tissues (i.e. tissue independent), with 73 loci demonstrating strong correlation with non-adjacent CMUs on the same chromosome. These loci were enriched for CTCF and transcription factor binding sites, always found within putative TADs, and associated with the B compartment of chromosome folding. Finally, we observed significantly different, but highly consistent, patterns of CMU correlation between diseased and non-diseased states. Our first-generation, genome-wide, DNA methylation map suggests a highly coordinated CMU regulatory network that is sensitive to disruptions in its architecture.
Association between a family history of cancer and multiple primary lung cancer risks: a population-based analysis from China
Authors: Ni Chen-Hui , Wang Mu-Ting , Lu Yan-Qi , Zheng Wei , Chen Chun , Zheng Bin
Published: May 2023

Objectives: The incidence of multiple primary lung cancer (MPLC) has increased in recent years. The risk factors of MPLC are not well studied, especially in the Asian population. This case-control study investigated the association between a family history of cancer and MPLC risk.
Methods: We used data from people who surgically confirmed MPLC with at least 2 nodes of Fujian Medical University Union Hospital and matched 1:2 normal individuals as controls between 2016 and 2017. Information on age, sex, lifestyle, personal history, and family history of cancer was collected using a self-administered questionnaire, and odds ratios (OR) were estimated using unconditional logistic regression.
Results: We included 2 104 patients. In total, 321 patients with histologically confirmed MPLC and 642 healthy controls were studied. The significantly higher ratio of current smokers was observed for the cases than the controls (54.1% vs. 30.0%). A family history of LC in first-degree relatives of the cases reported a significantly higher proportion than in the controls (15.3% vs. 8.6%). Family history of all cancers and LC significantly increased the risk of MPLC (OR = 1.64, P = 0.009 and OR = 2.59, P = 0.000, respectively). The multivariate analysis identified a significantly increased risk of MPLC (OR = 2.45, P = 0.000) associated with parents and siblings influenced by LC history. The younger age (aged < 55 years) of LC cases at diagnosis exhibited a significantly increased risk of MPLC (OR = 2.39, P = 0.000). A significant association with a family history of LC was found for male squamous carcinoma and male adenocarcinoma (OR = 1.59, p = 0.037 and OR = 1.64, p = 0.032, respectively). A positive association with LC history was only observed for female adenocarcinoma (OR = 2.23, p = 0.028). The risk of MPLC was not significantly associated with A family history of cancers in non-smokers (OR = 0.91, P = 0.236). Ever-smokers with a positive family history of cancer or LC had a significantly elevated risk of MPLC (OR = 4.01, P = 0.000 and OR = 6.49, P = 0.000, respectively). We also observed a very elevated risk for smokers with no family history (OR = 3.49, P = 0.000). Such a positive association was also observed in ever-smokers with no family history of LC (OR = 3.55, P = 0.000). Adenocarcinoma in females was prevalent and significantly associated with a family history of LC in risk of MPLC compared with other histologic subtypes.
Conclusions: Our findings suggest an association between a family history of LC and MPLC risk among an Asian population. Smoking status and family history of LC have a synergistic effect on MPLC. These findings indicate that MPLC exhibits familiar aggregation and that inherited genetic susceptibility may contribute to the development of MPLC.
Feasibility of a physical activity intervention for children and adolescents with anxiety and depression
Authors: Kodal Arne , Muirhead Fiona , Reilly John J. , Wergeland Gro Janne , Thorsen Paul Joachim Bloch , Bovim Lars Peder Vatshelle , Elgen Irene
Published: May 2023

Background: Physical activity is identified as a key modifiable factor towards good short- and long-term mental health and has shown positive effects on anxiety and depression in children and adolescents. However, physical activity-based interventions are not a part of standard mental health care and evidence on the effect of such interventions is still lacking. A transdiagnostic, physical activity-based intervention was developed as a supplement to routine clinical care for youth in specialized child and adolescent mental health services.
Methods/design: The feasibility of the physical activity intervention (Confident, Active and Happy Youth) was evaluated in an open-label study by assessing the recruitment process, acceptability, intervention suitability, contentment and preliminary intervention effects in the form of youth and parent rated anxiety and depressive symptoms. Physical activity levels were objectively measured using ActigraphTM physical activity sensors, and progression to a definitive study was evaluated in accordance with a-priori criteria.
Results: In total 21 of 25 eligible youth consented to participate, two dropped out of the intervention while 19 completed (76% of eligible participants). The retention rate among consenting participants was 89% and mean attendance to sessions was 83%. The suitability of the intervention was rated as good by youth and their parents, and intervention contentment was rated high. Effects on youth and parent-rated symptom measures following the intervention were negligible, except for parent-rated anxiety symptoms assessed at 10-month follow-up. Accelerometer data indicated lower levels of moderate to vigorous activity during sessions, than intended. No adverse effects were noted.
Conclusion: This feasibility study met the pre-determined progression criteria to a definitive study. Thus, a larger trial with longer follow-up should be conducted to explore the effect of the intervention.
Study registration:
ClnicalTrials.gov, NCT05049759. Retrospectively registered, 20.09.2021
Inverse Power Generalized Maxwell Distribution with Applications in Industry
Authors: Alsahangiti Arwa M. , Gemeay Ahmed M. , Sapkota Laxmi Prasad , Bakr Mahmoud E. , Benchiha SidAhmed , Balogun Oluwafemi Samson , Hossam Eslam , Shama Mustafa S.
Published: May 2023

Employing the inverse power transformation technique, we have proposed a new continuous three-parameter probability distribution and named it inverse power generalized Maxwell distribution. This distribution is the generalized version of the generalized Maxwell distribution. For this model, we have derived some functions related to survival analysis. Several statistical properties of the model are provided. This study also focused on the estimation of the unknown model parameters. Six different parameter estimation methods are employed and studied extensively through numerical simulation. To investigate the applications of the suggested model, two real engineering data sets are considered and empirically found that the suggested model can provide a superior fit as compared to some candidate models under study.\\ \\
\textbf{Keywords:} Generalize Maxwell distribution, Moments, Estimation, Inverse power, Entropy.
A cross-sectional study of the relationship between background noise and hearing threshold among Indian mine workers: formulating regression equations to reduce the false- positive hearing impairment cases
Authors: Nandi Subroto , Tank Nitishkumar D , Dhatrak Sarang V
Published: May 2023

Background noise is believed to affect audiometry results conducted particularly in non-soundproof booth in various occupational settings. The present study first of its kind investigated the effect of background noise on the results of audiometry among mine workers. Furthermore, the study formulated regression equations to rationalise audiometry conducted in a non-soundproof audiometry booth. In this cross-sectional study, audiometry was performed on mineworkers (n=388) divided into four groups with variable background noise outside the soundproof booth and then within the soundproof booth. The hearing levels of audiograms obtained outside and inside the soundproof booth were compared. A graph was plotted based on the differences in hearing level and background noise outside the audiometry booth. The relationship between variations in hearing level and background noise was explored using a coefficient of correlation. When the outside background noise level increased from 26 dB to 62 dB, the difference in hearing level increased from 2 dB to 27 dB across all groups. The mean hearing levels were found to be more affected at lower frequencies than at higher frequencies. Based on background noise and the variance in hearing level for each frequency, the study proposed regression equations. The study concluded that background noise had a greater impact on audiometry results at lower frequencies. Formulated regression equations may have the advantage of reducing the number of false positive hearing impairment cases that would have been identified in non-soundproof booths. The findings of the study are important particularly among mine workers in developing countries like India.