bluuebunny/crossref_metadata_2025 huggingface dataset:
Insulin binding characteristics in canine muscle tissue: effects of the estrous cycle phases
Authors: Pöppl Álan G. , Valle Sandra C. , González Félix H.D. , Kucharski Luiz C. , Silva Roselis S.M. da
Published: October 2016

Abstract: Hormonal fluctuations during the different estrous cycle are a well-recognized cause of insulin resistance in bitches, and little is known about insulin receptor binding or post-binding defects associated with insulin resistance in dogs. To evaluate insulin binding characteristics in muscle tissue of bitches during the estrous cycle, 17 owned bitches were used in the study (six in anestrus, five in estrus, and six in diestrus). An intravenous glucose tolerance test (IVGTT) was performed in all patients by means of injection of 1mL/kg of a glucose 50% solution (500mg/kg), with blood sample collection for glucose determination at 0, 3, 5, 7, 15, 30, 45 and 60 minutes after glucose infusion. Muscle samples, taken after spaying surgery, were immediately frozen in liquid nitrogen and then stored at -80 ºC until the membranes were prepared by sequential centrifugation after being homogenized. For binding studies, membranes were incubated in the presence of 20,000cpm of human 125I-insulin and in increasing concentrations of unlabeled human regular insulin for cold saturation. The IVGTT showed no differences among bitches during the estrous cycle regarding baseline glycemia or glycemic response after glucose infusion. Two insulin binding sites - high-affinity and low-affinity ones - were detected by Scatchard analysis, and significant statistical differences were observed in the dissociation constant (Kd1) and maximum binding capacity (Bmax1) of the high-affinity binding sites. The Kd1 for the anestrus group (6.54±2.77nM/mg of protein) was smaller (P<0.001) than for the estrus (28.54±6.94nM/mg of protein) and diestrus (15.56±3.88nM/mg of protein) groups. Bmax1 in the estrus (0.83±0.42nM/mg of protein) and diestrus (1.24±0.24nM/mg of protein) groups were also higher (P<0.001) than the values observed in anestrus (0.35±0.06nM/mg of protein). These results indicate modulation of insulin binding characteristics during different phases of the estrous cycle in dogs, showing that muscle insulin binding affinity for its receptor is reduced during estrus and diestrus. However, this poor hormone-receptor affinity is compensated for by a greater total binding capacity, once there is no difference in patients' glycemic response after an intravenous glucose load.
Identification of ultrastructural and functional damages in sperm from six-banded armadillos (Euphractus sexcinctus) due to cryopreservation
Authors: Sousa Patrícia C. , Santos Erika A.A. , Silva Andréia M. , Bezerra José A.B. , Souza Ana L.P. , Lima Gabriela L. , Oliveira Moacir F. , Silva Alexandre R.
Published: October 2016

Abstract: The aim of the study was to cryopreserve the semen of six-banded armadillos (Euphractus sexcinctus) in Tris-yolk and glycerol diluent, and to determine the damage caused by the freezing-thawing process, using fluorescent markers and ultrastructural analysis. Semen samples (n=11) collected from 4 adult six-banded armadillos by electroejaculation were cryopreserved in Tris diluent plus 20% egg yolk and 3% glycerol, in a fast freezing curve. Classical analysis of samples was performed after dilution, refrigeration and thawing, followed by fluorescence analysis, using a combination of fluorescent probes to assess membrane integrity (propidium iodide - PI and Hoechst - H342), and mitochondrial activity (CMXRos - Mito Tracker Red®). We also used the ultrastructural analysis to verify possible morphological alterations caused by cryoinjuries. When compared with fresh samples, we verified a significant decline in all the armadillos' semen parameters after thawing, in which only 6.1% motile sperm were found. However, the percentage of sperm which remained with viable (13%) and functional (24.7%) membranes after thawing suggests that some cells could be live but immotile. Analysis using fluorescent markers revealed that the mitochondria of armadillos' sperm is highly sensible to the freezing protocol and the findings through ultrastructure analysis proved this statement. Additionally, the images obtained by transmission electron microscopy revealed that frozen-thawed sperm presented damaged plasma membrane, nuclear modifications as changes in chromatin and acrossomal changes relative to sperm capacitation. In conclusion, this study is the first attempt to cryopreserve the semen of an armadillo species, and to help us to identify critical points on the freezing-thawing procedure in order to improve the protocol.
Effects of intracameral brilliant blue on the corneal endothelium of swine: in vitro study
Authors: Terzariol Mariana , Hünning Paula S. , Brambatti Gustavo , Albuquerque Luciane de , Neumann Carolina , Pigatto João A.T.
Published: October 2016

Abstract: The aim was to investigate the ultrastructural changes in the corneal endothelium of pigs induced by intracameral 0.05% brilliant blue. Twenty swine corneas were separated into two groups, the right eye bulbs (control group) and the left eye bulbs (experimental group) of the same animal. All the eye bulbs were evaluated with specular microscopy. The cornea of the right eye bulbs was excised and in the left eye bulbs 0.2ml of 0.05% brilliant blue vital dye (OPTH-blue±) was injected into the anterior chamber, where it remained for one minute. Then the anterior chamber was cleaned with a balanced salt solution injection and the cornea was excised too. All the corneas were evaluated by scanning electron microscopy to evaluate the changes on the endothelium caused by the brilliant blue dye. There were no significant differences between the right corneal endothelium cells and the left corneal endothelium cells with scanning electron microscopy after intracameral use of 0.05% brilliant blue dye. The 0.05% brilliant blue dye concentration did not cause deleterious effects for the swine corneal endothelium after intracameral use and can be a choice for safe staining of the anterior capsule of the lens in cataract surgery.
Células-tronco derivadas do epitélio olfatório: perspectivas terapêuticas na medicina veterinária
Authors: Mazzarella Rosane , Garnica Taismara K. , Roballo Kelly C.S. , Ambrósio Carlos E.
Published: October 2016

Resumo: O epitélio olfatório (EO) é uma fonte promissora de células-tronco (CTEO) para o uso terapêutico na medicina veterinária e humana, especialmente em doenças correlacionadas com o sistema nervoso periférico (medula espinhal) e central (cérebro e tronco encefálico) , pois as CTEO possuem a capacidade de se diferenciar em células do sistema nervoso, tais como: neurônios, oligodendrócitos e astrócitos. Em humanos estas células são utilizadas em ensaios terapêuticos de doenças degenerativas como o Alzheimer e Parkinson. Em animais a casuística relativa das doenças neurodegenerativas crônicas ou agudas é baixa, devido à dificuldade de diagnóstico definitivo, desta forma o enfoque das pesquisas com terapia celular são em sua grande maioria em lesões mecânicas na medula espinhal. Devido à falta de padronização e seleção das melhores metodologias que permitam confrontação de estudos, esta revisão busca reunir as mais recentes publicações, descrevendo o potencial uso das células-tronco do epitélio olfatório em terapias celulares, discutindo os principais desafios e perspectivas futuras com enfoque na medicina veterinária.
Factors associated with disease-specific survival of patients with non-small cell lung cancer
Authors: Souza Mirian Carvalho de , Cruz Oswaldo Gonçalves , Vasconcelos Ana Glória Godoi
Published: October 2016

ABSTRACT Objective: Lung cancer is a global public health problem and is associated with high mortality. Lung cancer could be largely avoided by reducing the prevalence of smoking. The objective of this study was to analyze the effects of social, behavioral, and clinical factors on the survival time of patients with non-small cell lung cancer treated at Cancer Hospital I of the José Alencar Gomes da Silva National Cancer Institute, located in the city of Rio de Janeiro, Brazil, between 2000 and 2003. Methods: This was a retrospective hospital cohort study involving 1,194 patients. The 60-month disease-specific survival probabilities were calculated with the Kaplan-Meier method for three stage groups. The importance of the studied factors was assessed with a hierarchical theoretical model after adjustment by Cox multiple regression. Results: The estimated 60-month specific-disease lethality rate was 86.0%. The 60-month disease-specific survival probability ranged from 25.0% (stages I/II) to 2.5% (stage IV). The performance status, the intention to treat, and the initial treatment modality were the major prognostic factors identified in the study population. Conclusions: In this cohort of patients, the disease-specific survival probabilities were extremely low. We identified no factors that could be modified after the diagnosis in order to improve survival. Primary prevention, such as reducing the prevalence of smoking, is still the best method to reduce the number of people who will suffer the consequences of lung cancer.
Prevalence of alpha-1 antitrypsin deficiency and allele frequency in patients with COPD in Brazil
Authors: Russo Rodrigo , Zillmer Laura Russo , Nascimento Oliver Augusto , Manzano Beatriz , Ivanaga Ivan Teruaki , Fritscher Leandro , Lundgren Fernando , Miravitlles Marc , Gondim Heicilainy Del Carlos , Santos Junior Gildo , Alves Marcela Amorim , Oliveira Maria Vera , Souza Altay Alves Lino de , Sales Maria Penha Uchoa , Jardim José Roberto
Published: October 2016

ABSTRACT Objective: To determine the prevalence of alpha 1-antitrypsin (AAT) deficiency (AATD), as well as allele frequency, in COPD patients in Brazil. Methods: This was a cross-sectional study involving 926 COPD patients 40 years of age or older, from five Brazilian states. All patients underwent determination of AAT levels in dried blood spot (DBS) samples by nephelometry. Those with DBS AAT levels ≤ 2.64 mg/dL underwent determination of serum AAT levels. Those with serum AAT levels of < 113 mg/dL underwent genotyping. In case of conflicting results, SERPINA1 gene sequencing was performed. Results: Of the 926 COPD patients studied, 85 had DBS AAT levels ≤ 2.64 mg/dL, and 24 (2.6% of the study sample) had serum AAT levels of < 113 mg/dL. Genotype distribution in this subset of 24 patients was as follows: PI*MS, in 3 (12.5%); PI*MZ, in 13 (54.2%); PI*SZ, in 1 (4.2%); PI*SS, in 1 (4.2%); and PI*ZZ, in 6 (25.0%). In the sample as a whole, the overall prevalence of AATD was 2.8% and the prevalence of the PI*ZZ genotype (severe AATD) was 0.8% Conclusions: The prevalence of AATD in COPD patients in Brazil is similar to that found in most countries and reinforces the recommendation that AAT levels be measured in all COPD patients.
Effects of passive inhalation of cigarette smoke on structural and functional parameters in the respiratory system of guinea pigs
Authors: Vasconcelos Thiago Brasileiro de , Araújo Fernanda Yvelize Ramos de , Pinho João Paulo Melo de , Soares Pedro Marcos Gomes , Bastos Vasco Pinheiro Diógenes
Published: October 2016

ABSTRACT Objective: To evaluate the effects of passive inhalation of cigarette smoke on the respiratory system of guinea pigs. Methods: Male guinea pigs were divided into two groups: control and passive smoking, the latter being exposed to the smoke of ten cigarettes for 20 min in the morning, afternoon and evening (30 cigarettes/day) for five days. After that period, inflammatory parameters were studied by quantifying mesenteric mast cell degranulation, as well as oxidative stress, in BAL fluid. In addition, we determined MIP, MEP, and mucociliary transport (in vivo), as well as tracheal contractility response (in vitro). Results: In comparison with the control group, the passive smoking group showed a significant increase in mast cell degranulation (19.75 ± 3.77% vs. 42.53 ± 0.42%; p < 0.001) and in the levels of reduced glutathione (293.9 ± 19.21 vs. 723.7 ± 67.43 nM/g of tissue; p < 0.05); as well as a significant reduction in mucociliary clearance (p < 0.05), which caused significant changes in pulmonary function (in MIP and MEP; p < 0.05 for both) and airway hyperreactivity. Conclusions: Passive inhalation of cigarette smoke caused significant increases in mast cell degranulation and oxidative stress. This inflammatory process seems to influence the decrease in mucociliary transport and to cause changes in pulmonary function, leading to tracheal hyperreactivity.
Gel pillow designed specifically for obstructive sleep apnea treatment with continuous positive airway pressure
Authors: Salvaggio Adriana , Lo Bue Anna , Isidoro Serena Iacono , Romano Salvatore , Marrone Oreste , Insalaco Giuseppe
Published: October 2016

ABSTRACT Objective: To determine whether the use of a gel pillow with side cutouts designed to accommodate a continuous positive airway pressure (CPAP) mask and reduce head temperature improves the efficacy of and adherence to auto-CPAP therapy. Methods: Twenty-three consecutive CPAP-naïve patients with obstructive sleep apnea were enrolled in the study. Patients were given an auto-CPAP machine with an appropriate CPAP mask and were instructed to use CPAP for 15 nights. They were instructed to sleep with their own pillow (the control pillow) from nights 1 to 5 and with either a foam pillow or a gel pillow, both of which had side cutouts, for 5 consecutive nights each, in random order. After night 15, auto-CPAP machine data were downloaded and patients rated their satisfaction with each pillow on a visual analog scale. Results: Twenty-two patients completed the protocol. The pressures administered, residual apnea-hypopnea index, air leaks, and mean duration of CPAP use did not differ among the periods during which each pillow was used. Patients were significantly more satisfied with the gel pillow than with the control pillow and the foam pillow (p = 0.022 and p = 0.004, respectively), their level of satisfaction with the gel pillow correlating significantly with excessive daytime sleepiness (r2 = 0.19; p = 0.0443). Conclusions: Among obstructive sleep apnea patients treated with nasal CPAP, the use of a gel pillow with side cutouts appears to have no impact on treatment effectiveness. Nevertheless, such patients seem to prefer a gel pillow over other types of pillows.
Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis?
Authors: Muñoz-Torrico Marcela , Rendon Adrian , Centis Rosella , D'Ambrosio Lia , Fuentes Zhenia , Torres-Duque Carlos , Mello Fernanda , Dalcolmo Margareth , Pérez-Padilla Rogelio , Spanevello Antonio , Migliori Giovanni Battista
Published: October 2016

ABSTRACT The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the "post-tuberculosis treatment" phase, which will potentially affect several million cases every year. We carried out a non-systematic literature review based on a PubMed search using specific keywords (various combinations of the terms "tuberculosis", "rehabilitation", "multidrug-resistant tuberculosis", "pulmonary disease", "obstructive lung disease", and "lung volume measurements"). The reference lists of the most important studies were retrieved in order to improve the sensitivity of the search. Manuscripts written in English, Spanish, and Russian were selected. The main areas of interest were tuberculosis sequelae following tuberculosis diagnosis and treatment; "destroyed lung"; functional evaluation of sequelae; pulmonary rehabilitation interventions (physiotherapy, long-term oxygen therapy, and ventilation); and multidrug-resistant tuberculosis.The evidence found suggests that tuberculosis is definitively responsible for functional sequelae, primarily causing an obstructive pattern on spirometry (but also restrictive and mixed patterns), and that there is a rationale for pulmonary rehabilitation. We also provide a list of variables that should be discussed in future studies on pulmonary rehabilitation in patients with post-tuberculosis sequelae.
A harmony-based calibration tool for urban drainage systems
Authors: De Paola Francesco , Giugni Maurizio , Pugliese Francesco
Published: October 2016

The US Environmental Protection Agency's storm water management model SWMM 5·1 is widely used to simulate urban drainage processes both for qualitative and quantitative analysis. In the present work, SWMM 5·1 was applied to the Fossolo urban sub-catchment in Bologna, Italy, and the geographic information system ArcGIS was adopted to reproduce the spatial distribution of rainfall. An innovative and original optimisation procedure was developed, coupling the jazz-music-based harmony search evolutionary algorithm with SWMM 5·1 for the estimation of runoff parameters. Seven historical storm events were taken into account for model calibration and validation. A careful sensitivity analysis highlighted the effectiveness of the calibrated parameters for simulations. The results obtained showed the proposed approach to be a useful tool for the calibration of hydrological parameters in large urban drainage systems, defining a satisfactory correlation between modelled and measured data.
Inter-Channel Connectivity Analysis of Electroencephalograms Based On the Correlation Ratio
Authors: Ивановский Р.И. , Ivanovskiy R.I.
Published: October 2016

We offer an approach to the inter-channel connectivity analysis of EEG using correlation ratios which can objectively estimate characteristics
of interactions in all their models. It is shown that the values of the correlation ratios can serve as an indicator of nonlinear correlation.
The ability to analyze multiple interactions is shown on the basis of the proposed correlation ratio matrix. The concept of dominant channels
is introduced. Algorithms and analysis software are discussed.
Fractal Model of the Protoplant's Appearance
Authors: Галицкий В.В. , Galitskii V.V.
Published: October 2016

Sectional model of the tree's system branches, which was published earlier, was extended on the range (0.1) of model's allometric parameter μ,
relating the magnitude of the green biomass of a tree and its size (for spruce μ ≈ 1.83). The model showed the presence of a green biomass in this range.
According to the statements of fractal geometry this points out a possibility to interpret the placement of green biomass as a set of photosynthesis
points. In turn according to contemporary notions about endosymbiotic character of appearance of organelles in eukaryotic cell this was interpreted
as begin of endosymbiosis of cyanobacteria and a host (protist). This has been modeled by the groups’ placement of growing number of points on
an interval under initial limitation of the number of points per group. The limitation is connected to the initial absence in protist an infrastructure
which is need for the growing number of cyanobacteria. It was demonstrated that initially in course of increasing total points number the parameter μ
decreases from 1.0 to 0.25 under the fixed number of points per group and then increases to 1.0 under the fixed number of groups. This gives
an initial braking (slowdown) of growth of protoplant's size (a characteristic geometrical dimension of set of points) and then exponential growth
after deleting limitation of point number per group in evolution's course of host endosymbiosis similarly to higher plants. Morphological analogy
of situations of begin of plant embryogenesis and begin of seed germination with the situation described by the model of protoplant appearance
is discussed.
Diarios Narrativos: Relaciones y Encuentros en Educación Secundaria
Authors: Cabrera Cuadros Valeska , Fuentes Quesada Laura
Published: October 2016

During the academic year 2014-2015, an investigation was conducted in an innovative school in Barcelona where a teacher used personal diaries written by its students during their Catalan lessons in 2nd high school. The objective of this activity was to use this tool to work with and from the students’ emotions, and create a communication channel to enhance closeness in the student-teacher relationship that would also benefit their Catalan language learning process. The second stage of the study includes four participants: three students and one teacher. The objectives are: (a) to do a follow-up on the agents who were involved in the creation of personal diaries and (b) to see what this type of activity made them feel in terms of communication and relationship between teacher-student. The method that has guided this work is biographical narrative and some of the conclusions are that the use of narrative newspapers could be a useful tool in improving teaching and even learning itself because it helps establish links between teacher-student and because it allows expressing the experiences using language first hand.
Self-Reported Benefits and Adverse Outcomes of Hot Yoga Participation
Authors: Mace Casey , Eggleston Brandon
Published: October 2016

Background: There is little to no scientific data about the health benefits or risks to participating in hot yoga, in particular distinguishing it from the practice of non-hot yoga. Aims: This study aims to provide some preliminary evidence about the risks and benefits of participating in hot yoga. Future studies will be able to build off the findings herein. Methods: This study utilized online survey software (Qualtrics) and recruited participants through convenience sampling (n = 157) by targeting yoga websites and online forums. As there is currently no known questionnaire that has been developed to assess the risks and benefits of hot yoga participation, an exploratory measure was designed to gain more detailed responses from participants. Descriptive epidemiological analyses we re conducted. Results : Participants of hot yoga had a number of pre-existing health conditions. Both benefits and adverse outcomes were reported. The most frequently reported health benefits of hot yoga in this sample included increased flexibility (63%), improved mood (58%), increased fitness (43%), and improved stamina (42%). Just over half of the participants reported some sort of adverse event during a hot yoga session (n = 82). The most commonly reported adverse events included dizziness (60%), feeling light headed (61%), nausea (35%), and dehydration (34%), amongst others. Conclusions: Further study on the risks and benefits of hot yoga participation is required.
Influence OF parental DEPRIVATION on THE STRUCTURE OF Motivational sphere OF children with NON - SOCIAL FRUSRATUION OF BEHAVIOUR
Authors: Novikov V V , Petrov S S
Published: October 2016

The important question of childhood psychiatry is: which are the features of personality structure of the child with CD?
The analysis of the literature shows that findings in this sphere are extremely contradictory. The authors examined by Szondi Test two groups of children with childhood-onset unsocialized conduct disorder (UCD). The data demonstrate that the child personality structure and dynamics of UCD are connected with parent's deprivation.
The development of the cultural-creative aspect in information world outlook of a person
Authors: Sokolina E N
Published: October 2016

In the article there are given ways of the development of the cultural creative aspect in information world outlook of a person.The obtained data proves that the development of the cultural-creative aspect in information world outlook of a person is a necessary condition of the effective formation of the information culture.
Quality of life of patients who was exposed a hemygasrectomy
Authors: Tarasenko S V , Zaitsev O V , Kopeykin A A , Motin A P , Rakhmaev T S
Published: October 2016

Quality of life of patients who was exposed a hemygasrectomy is investigated. For an assessment of quality of life questionnaire SF-36 is used. Analysis was effected in the basic and control bunches. The basic bunch - 21 patient who was exposed a resection of a stomach on Bilrot-1, control bunch - 29 patients, suffering a peptic ulcer. There was, that a degree of quality of life of the patients who was subjected a resection of a stomach are higher, than the qualities of life of the patients, suffering a peptic ulcer . The maximal difference as life of the basic and control bunches has been received by criteria: the role functioning caused by a physical state, a pain, vitality, social functioning and the role functioning caused by an emotional state. Improvement of quality of life of the patients who was subjected a hemygastrectomy, is achieved not only due to physical, but also due to a psychologic component of health
SYMPTOMS OF THE BOTTOM URIC WAYS AND CHRONIC PROSTATITIS WITH PATIENTS HAVING GOOD-QUALITY PROSTATE HYPERPLASIA
Authors: Aristarchov V G , Zhiborev B N , Martov A G , Zhiborev A B
Published: October 2016

The article is devoted to analysis of results of exposing and treatment chronic prostatitis in patients with benign prostatic hyperplasia.
Neurologic Frustration at Asthma
Authors: Kiruhina N N , Burshinov A O , Rakita D R
Published: October 2016

Examination of 96 patients with asthma mowed that 66 (68,8 %) patients had the syndrome of psycho-vegetative disorders, 42 (63,6 %) patients among them had mild diffuse focal symptomatology
CONDITION OF STOMATOLOGIC HEALTH OF THE PERSONS OF THE ABLE-BODIED AGE LIVING IN VARIOUS REGIONS OF THE CENTRAL FEDERAL DISTRICT
Authors: Breusov R A , Konovalov O E , Rodina T S , Fedotova N N
Published: October 2016

The description of the complex social - hygienic research lead by authors on studying the reasons, structures and a level of stomatologic desease of the able-bodied population living in various subjects of the Central Federal district is devoted. On the basis of an estimation of a condition of stomatologic health of the population the recommendations directed on his improvement are developed.
THE DEVELOPMENT OF THE OPTIMUM EXSTRACTION TECHNOLOGY OF THEREGULATOR ALBUMEN WITH THE GEPATO-PROTECTORS ACTIONS FROMBIOTECHNOLOGICAL RAW MATERIAL
Authors: Privalov I M , Stepanova E F , Jamskova V P
Published: October 2016

The complex researches of the optimum extraction technology of the regulator albumen with the gepato-protectors actions from biotechnological raw material are resulted. For the first time the optimum extraction conditions of the regulator albumen from the biotechnological raw material, possessing the gepato-protectors actions are revealed and proved; the technology of their manufacture is developed and biological criteria describing their quality are chosen.
Morphological characteristics of thyroid gland in case of acute ischemic disease of heart
Authors: Levitin A V , Uhov Y I
Published: October 2016

In this work we analyzed the role of thyroid pathology in case of development of severe forms of acute ischemic disease of heart. We demonstrated clinic-al anatomical observations of numerous cases which confirm the meaning of subclinical hypothyroidism as a risk factor for acute myocardial infarction development. There is a set of microphotos histogical preparations of thyroid glands of people died from severe forms of ischemic disease of heart.
THE ECONOMIC ANALYSIS OF ACTIVITY OF VERSATILE HOSPITAL
Authors: Likstanov M I , Rejmer V V , Breusov A V
Published: October 2016

The description of a technique of the analysis of economic efficiency of work of structural divisions offered by authors and treatment-and-prophylactic establishment as a whole is given. The given
Treatment of intestinalinsufficiency withconstant infusion ofropivakain in caseof generalizedperitonitis
Authors: Midlenko Vadim Il'ich , Zaytseva O B , Lyubaev A Yu , Smol'kina A V , Zaytsev A V , Midlenko O V , Midlenko V I , Zaytseva O B , Lyubaev A Yu , Smolkina A V , Zaytsev A V , Midlenko O V
Published: October 2016

The article represents the performance evaluation of intensive therapy of postoperative intestinal insufficiency in case of generalized peritonitis. 81 patients with postoperative intestinal insufficiency were examined. Constant infusion of 0,5% solution of ropivakain was taken in peridural space (6-10 ml/h). Application of proposed treatment regimen of intestinal insufficiency leads to faster reliable regress of dynamic intestinal insufficiency ultrasound signs, what may cause the beginning of early enteral feeding (from 3-rd day of postoperative stage).
The main procedures of the program«Pharmaceutical economicsafety»
Authors: Kuznetsov Dmitriy Anatol'evich , Kuznetsov D A
Published: October 2016

In this article is presented the order of the analysis of a degree of economic safety of pharmaceutical systems on the basis of modern information technologies. With usage of the main procedures of the software the technology of acceptance of administrative solutions on support of economic safety in pharmacy is described.
Orientation andcomposition ofcollagen fibers withinthe scar aftermyocadial lesion in ratfetuses
Authors: Bol'shakova Galina Borisovna , Bolshakova G B
Published: October 2016

This study was undertaken to examine orientation and composition of collagen fibers within the myocardial scar after mechanical injury in 16-day-old rat fetuses and in adult male rats. Measurements were performed from 7 to 40 days after lesion. Angles of fiber bundles relative to the longitudinal axis of wound channel were measured and were analyzed with circular statistic techniques. Proportion of collagen types I and III was determined when studying sections stained with picrosirius red under polarized light. In adult myocardium fibers of collagen type I were abundant and longitudinally aligned, the lesion developed into a mature scar. Fetal scar contained thinner fibers, which did not display a homogeneous distribution. This suggests that fetal scar is immature, its mechanical strength is less and that fetal myocardium shows incomplete repair.
INFLUENCE OF DIPYRIDAMOLE AND ATP ON IMMUNOSUPRESSING PROPERTIES OF ERYTHROCYTES AND THROMBOCYTES IN EXPERIMENTAL NON - OBSTRACTIVE PYELONEPHRITIS
Authors: Siplivyi G V , Lazarev A I , Siplivaya L E , Kukureka A V
Published: October 2016

Investigations on 175 Wistar rats showed that thrombocytes of animals with non-obstructive pyelonephritis have possessed immunosupressing properties being increased on interaction with light erythrocytes and serum factors, accumulated in blood of rats with pyelonephritis. Introduction of dipyridamole and ATP blocked thromboerythrocyte chain of immunosuppression development in rats with pyelonephritis. Here, the pyridamole action was directed to thrombocyte - erythrocyte unit, and the ATP action - to light erythrocytes.
KARIOMETRICHESKIE INDICATORS OF ACTIVITY IN HUMAN THYROID FOLLICLES IN THE ASPECT OF AGE AND GENDER
Authors: Ukhov Y I , Kolobaev A V , Voroninа R K
Published: October 2016

The article shows kariometrii thyrocytes thyroid gland and its results are compared with the nature of the activity of follicles according to gender and age. Found that the average volume of nuclei of thyrocytes in the follicles "active" type with opposite-sex persons than the corresponding figures for follicular "inactive". At the same time and both men and women the maximum mean volume of nuclei is reached in the period 50 - 54 years.
Oxidizing modificationof albumens in plasmaof blood of patients bydiabetes mellitus oftype 2 iin dependence ondegree ofindemnification ofcarbohydrateexchange and durationof diabetes mellitus oftype 2
Authors: Zanozina Ol'ga Vladimirovna , Shcherbatyuk Tat'yana Grigor'evna , Borovkov Nikolay Nikolaevich , Zanozina O V , Scherbatuc T G , Borovkov N N
Published: October 2016

Oxidizing stress at diabetes mellitus ( DM) of type 2 characterized by the generation of free radicals, leading, in
particular, to oxidizing modification of albumens. It is rotined that modification of albumens takes place and at
subcompensation of carbohydrate exchange, however much maximal changes take place at decompensation of DM of
type 2 large durations. For the estimation of stage, orientation, expressed of oxidizing stress for the patients of DM of
type 2 it is suggested to use different parts of OMB and their correlations. Not enough for indemnification of
carbohydrate exchange breaking of vicious circle ( a generation of free radicals is oxidizing modification of albumens
is oxidization of lipids - generation of free radicals).
Investigation of some aspect ofpsychic status in patients withcolorectal cancer
Authors: Semionkin Evgeniy Ivanovich , Yakovleva Natal'ya Valentinovna , Trushin Sergey Nikolaevich , Semionkin E I , Yakovleva N V , Trushin S N
Published: October 2016

In this study weve evaluated psychic status of men and women with colorectal cancer of 3 and 4 stages before
an operation and after it.
Weve used Lushers color test, Spielberger test (Spielberger C. D., 1970) to evaluate the situational and
personal anxiety level processed by Hanina Y.L. [9] and personal anxiety scale according Tailor.
Weve discovered that patients, especially women, had serious stress reaction, had neurologic syndromes and
anxiety-depression condition with adaptation disorders.
Study nature nerve fiberscauses of increasedabbreviations duodenalduring stimulation of the sympatheticnerve
Authors: Sveshnikov D S , Myasnikov VM IL , Kuchuk A V , Trofimova Yu E , Trubetskaya M A , Sveshnikov D S , Myasnikov VM IL , Kucuk A V , Trofimova Y E , Trubetskaya M A , Smirnov I L , Smirnov I L
Published: October 2016

In experiments on dogs showed that stimulyatornye reactions induced by electrical stimulation of the sympathetic nerve on
the background of a joint blockade of α-adrenergic fentolaminom and β-adrenoceptor propranolol almost completely
eliminated lizergolom-blocker S1, 2 receptors. In this introduction lizergola had no significant effects on both the background
motor activity of duodenal ulcer, and on the function of the vagus nerve. Concluded that the effector neuron with which
realized stimulyatorny phenomenon is serotonin, its effects are carried out with the help of S1, 2 - receptors of smooth
muscles
Comparative efficacy of drugs ofdifferent pharmacotherapeuticgroups in experimental toxichepatitis
Authors: Tauki Akhmed Nabil , Fedorov V N , Kunitsa Z A , Smirnov N A , Kochneva N V , Taouk A N , Fiodorov V N , Kunitsa Z A , Smirnov N A , Kotshneva N V
Published: October 2016

This article discusses the evaluation of pharmacological effectiveness of drugs of different pharmacotherapeutic
groups in an experimental model of toxic hepatitis. The method of two-stage pharmacological screening. Key findings: of
immunomodulators were found drugs worsen the condition of the liver against toxic hepatitis, the combination of
essential phospholipids and glycyrrhizic acid is substantially more important hepatoprotective activity, in comparison
with the effectiveness of this combination of components that are applied separately, the number of members of the group
of adaptogens immunostimulant effect of which is the only one component of their actions, have a more pronounced
hepatoprotective activity compared with the specialized immunomodulators
Harmonization analysisof hospital formularyand essential drug listsof federative level
Authors: Yakusheva E N , Yakusheva E N
Published: October 2016

The paper characterizes use of harmonization analysis of hospital formulary and Lists of Essential Drugs of
Federative level as method gives quality evaluation of drug selection and is recomended for examination.
REVIEW pharmacotherapy Peyronie's disease
Authors: Karaguzhin S K , Kovalev V A , Koroleva S V , Abdulkhamidov A N , Karaguzhin S K , Kovalev V A , Korolev S V , Abdulhamid A N
Published: October 2016

Peyronie's disease - is a local idiopathic fibrosis developing in the tunica of the penis, which subsequently leads to a curvature of the penis and sexual dysfunction. Therapy is conducted in the chronic stage, or stage of the stabilization process, especially when there are signs of calcification plaques, found to be ineffective. The main goal of therapy is aimed at stopping the inflammatory process and the maximum preservation of tunica albuginea from defeat indurative process and the reduction of pain syndrome arising during erection. Conservative therapy of Peyronie's disease, currently, is shown in the acute stage, which lasts from 6 to 18 months.
ANATOMIC VARIATIONS AND asymmetry in Anterior chest wall in women
Authors: Sergeev I V , Shikhirman E V , Puchkov K V , Sergeev I V , Shihirman E V , Puchkov K V
Published: October 2016

Kind of mammary glands in women as in an aesthetic sense and in terms of symmetry depends not only on the condition of breast tissue, but also from the anterior contour of the chest. If reconstructive or Augmentation interventions on the type of mammary glands are strongly influenced by the size, shape and location of implants. Understanding the diversity of forms and degree of asymmetry may help in the planning of surgical treatment to achieve an aesthetically acceptable result.
According to X-ray computed tomography was obtained to assess the prevalence of anatomic changes and the asymmetry of the anterior chest wall in women. These results underscore the importance of evaluating the contour anterior chest wall at the planning stage of rapid increase in breast cancer in
order to achieve predictable aesthetic results.
SOCIAL PHARMACOLOGY: THE NEW INTERDISCIPLINARY SCIENTIFIC DIRECTION
Authors: Mikhaylova D O , Mikhailova D O
Published: October 2016

Consideration of medical and sociological problems in the field of drug development and administration is expedient within the limits of a new interdisciplinary direction of a medical science on a joint of clinical pharmacology and sociology of medicine. Subjects of studying of social pharmacology are both interrelations of pharmacological activity and social factors, and set of medical and social processes by development, manufacture, turnover and utilization of drugs. On the basis of socially-pharmacological approaches probably creation of new tools for optimization of activity of authorities, scientific institutions, the medical and pharmaceutical organizations on perfection of drug development and administration.
Immunomorphological CHARACTERISTICS experimental chronic autoimmune prostatitis
Authors: Tsvetkov I S , Mkhitarov V A , Tsvetkov IS , Mkhitarov V A
Published: October 2016

In experiments on Wistar rats was reproduced by a model of chronic autoimmune prostatitis introduction homogenate additional sexual glands of rats. For morphometrical and morphological study of histological slides of the prostate were identified degenerative and proliferative epithelial changes acini, inflammatory infiltration, focal fibrosis. For immunofluoresence study revealed deposits of IgG in the basal plate epithelial acini processing sections of prostate serum of rats with chronic prostatitis. In the culture fluid of splenocytes was reduced levels of IL-4, TNF-α.
SCIENCE-BASED PLANNING OF ADDRESSED ANTI-DRUG EVENTSAND IT'S EFFECT (THE EXAMPLE OF KURSK REGION)
Authors: Timoshilov Vladimir Igorevich , Sidorov Gennadiy Alekseevich , Timoshilov V I , Sidorov G A
Published: October 2016

The article presents narco-predisposition as a medical and social problem of young people, results of the expert evaluation of different risk-factors, methodic of its monitoring and planning addressed preventive events according to its results. The choice of forms of work is based on the author's research.
Clinical specific features of grippe-induced severe out-patient form of pneumonia
Authors: Abrosimov V N , Almazova E V , Abrosimov V N , Almazova E V
Published: October 2016

The aim of the article is to study clinical specific features of grippe-induced severe out-patient form of pneumonia (OPP) using the comparative analyses of clinical, laboratory and x-ray examination data of severe out-patient form of pneumonia which was not connected with acute respiratory virus infection (ARVI). The first group included 25 patients (mean age - 35,6±2,8 years) with severe OPP induced by grippe. All patients were infected by grippe virus A/H1N1 swl. The second group consisting of 25 patients (mean age - 50,6±3,8 years) with severe OPP which was not associated with ARVI. Young and middle aged persons had grippe-induced OPP in whom the obesity of the II and III stages was the background disease of 28 % of patients. Fever (39,1 ºC or more) was marked in 60% of cases, the mean duration period of fever was 15,1±2,1 days. Stab neutrophil shift secondary or normal total amount of leucocytes was noted. 48% of cases showed the increase of transaminase level. It appeared that the lesion of two lobes of the lungs (76%) and bilateral damage of pulmonary tissue (72%) were characteristic signs. Complications in grippe-induced pneumonia occurred frequently. Acute respiratory distress syndrome (ARDS) was seen in 12% of cases.
Dynamics of recovery of the lymphoid formations of a small intestine after influence of emotional stress
Authors: Ivanova Elena Aleksandrovna , Koplik Elena Vladimirovna , Sapin Mikhail Romanovich , Sudakov Konstantin Viktorovich , Ivanova E A , Koplik E V , Sapin M R , Sudakov K V
Published: October 2016

The study revealed that the severity and duration of response of the lymphoid formations in the walls of the small intestine to acute emotional stress depends on the individual organism's resistance to the stress exposure. Despite the fungible nature of the response of lymphoid structures in the stressors, their reaction in the group of stress-resistant rats was less pronounced, and recovery times are shorter compared to the stress-prone animals.
INDICATORS OF THE CASE RATE AND CONDITION OF THE IMMUNO-BIOCHEMICAL HOMEOSTASIS AT ТЕПЛИЧНИЦ DEPENDING ON THE PROFESSIONAL EXPERIENCE
Authors: Dubovaya Natal'ya Ivanovna , Dubovaya N I
Published: October 2016

Studying of structure of a case rate, immune-allergological and biochemical indicators at working women of hothouses with the different experience of industrial contact to pesticides is spent. The interrelation between development immune-allergological reorganisations of reactance of an organism, degree of disturbance of a functional condition of a liver at working women of hothouses and duration of the professional experience is taped. In case rate structure of working women of hothouses prevail immune-pathological the disturbances which structure changes depending on the professional experience.
DEPARTMENT OF QUALITY MANAGEMENT - UNIT FOR MANAGEMENT SYSTEM IMPROVEMENT OF MEDICAL AND PREVENTIVE TREATMENT FACILITY'S QUALITY
Authors: Anishchenko Petr Nikolaevich , ANICHENKO P N
Published: October 2016

The basic functions of the Multidisciplinary Hospital's quality management department are described in this article. This department was created in order to: 1. coordinate the actions of hospital staff and as a result to improve quality management, 2. enhance continuity between the units and 3. organize the institution functioning in accordance with the requirements of Russian and international standards ISO 9001. As the result of the quality management department activity the hospital obtained the certificate of quality management system compliance to the requirements of the RF State Standards GOST R ISO 9001-2001 (ISO 9001:2000). This certificate was issued to the hospital in 2008. Moreover, due to department of quality management work key performance indicators were improved.
SHORT-TERM AND LONG-TERM RESULTS OF RADICAL R0 MULTIORGAN RESECTIONS FOR ADVANCED STOMACH CANCER
Authors: Karachun Aleksey Mikhaylovich , Samsonov Denis Vladimirovich , Karachun A M , Samsonov D V
Published: October 2016

The results of surgical treatment of 169 patients with R0 combined resections performed in the period from 2000 to 2005 due to advanced stomach cancer were analyzed. The postoperative morbidity rate was 31,4 ± 3,3%, postoperative mortality rate was- 7,1 ± 1,0%. The overall 5-year survival rate was 24,1 ± 3,1%, median of survival was 16 months. The categories of patients with R0 resections which have not improved the treatment long-term results were identified. This requires a differentiated surgical treatment for patients with advanced stomach cancer
Lifetime anatomy and topography of the retroperitoneal spaces fascias
Authors: Lyashchenko Sergey Nikolaevich , Lyashchenko S N
Published: October 2016

The purpose of work is studying lifetime computer-tomographic anatomy of the retroperitoneal spaces fascias. As object of research the computer tomograms received from 140 patients without a pathology of organs of a retroperitoneal spaces have served. As a result of carried out research are received morphometrical parameters of all retroperitoneal spaces fascias of the person. Opportunities of their visualization are found out from persons of three age groups, sexual distinctions are studied. The alternative anatomy and topography of everyone fascias of the retroperitoneal spaces is described. Results of work can be useful to surgeons, urologists, morphologists.
EXPERIENCE OF REALIZATION OF PRINCIPLES OF SOCIOLOGICAL MONITORING IN PUBLIC HEALTH SERVICES
Authors: Grishina Natal'ya Konstantinovna , Kicha Dmitriy Ivanovich , Grishina N K , Kicha D I
Published: October 2016

In article materials of approbation of principles of sociological monitoring of availability and quality of medical aid to the population, and also its knowledge on various questions of the organization of functioning of system of public health services and obligatory medical insurance are resulted. Results of three consecutive поросов, spent in various territories of the Russian Federation, allowed to receive the information on dynamics of the relation of the population to problems of rendering of medical aid are presented. The importance of monitoring researches in management of public health services is underlined
EFFECTS OF STATINES ON ACTIVITY OF LYSOSOMAL HYDROLASES IN ALLOXAN DIABETES
Authors: Polupanov A S , Polupanov A S
Published: October 2016

Paper shows that alloxan diabetes in rats increases nonsedimenteted activity of lysosomal hydrolases in liver, myocardium and skeletal muscle, but decreases nonsedimenteted activity of them. Lovastatin and simvastatin cause decreases of expressiveness of these processes in rats with alloxan diabetes
Sudden Coronary death frequency, detectability and statistical recording
Authors: Nikulina N N , Nikulina N N
Published: October 2016

Specification of Sudden Coronary Death (SCD) prevalence, diagnostics quality and statistical recording in outpatients' clinics. Materials and methods. Comparative analysis of SCD prevalence, recorded in outpatients' clinics and qualified per study algorithm, was performed in 285 736 population (76.4% of them ≥18 лет, 46.0% - males). Results. Qualified SCD frequency accounted 156 per 100 000 male population and 72 per 100 000 female population, that in 2,3 и 2,8 times more then recorded in outpatients' clinics level (р
THE REALIZATION OF GENERAL ADAPTATION SYNDROME IN THE SYSTEM OF HAEMOSTASIS AT THE LOCAL AND SYSTEM LEVELS BY ENDOVIDEOSCOPIC INVASIONS
Authors: Ivanov Vladislav Valerievich , Ivanov V V
Published: October 2016

In the accomplished clinical-experimental research the results of studying coagulation, countercoagulation and fibrinolitic system and functional activity of thrombocytes during endovideoscopic invasions. Here are shown differences in the system of haemocoagulation at the local and system levels, the dependence of the current changes on the stress reaction level.