bluuebunny/crossref_metadata_2025 huggingface dataset:
RDIGITALIZATION OF ACCOUNTING PROCESSES IN AGRICULTURAL ENTERPRISES: OPPORTUNITIES, CHALLENGES, AND TRANSFORMATION PERSPECTIVES
Authors:   State Biotechnological University, Mazorenko Mariia
Published: February 2025

The article emphasizes that digitalization is not just a technological upgrade but a strategic necessity for agricultural enterprises to remain competitive in a rapidly evolving global market. It discusses how integrating digital technologies can facilitate real-time monitoring and predictive analytics, enabling enterprises to respond proactively to market and environmental changes. Furthermore, the research highlights the role of government policies and financial incentives in mitigating the challenges associated with adopting digital tools, particularly for small and medium-sized enterprises. By providing a roadmap for overcoming barriers, the study aligns the potential of digital transformation with the long-term goals of enhancing resilience and promoting environmentally sustainable practices in agriculture. The article explores the role and impact of digitalization on the accounting processes of agricultural enterprises. It highlights the advantages of implementing digital technologies, including ERP systems, artificial intelligence, Big Data, blockchain, and the Internet of Things (IoT), for automation, analysis, and efficiency improvement in management. The study examines key trends in the digital products market, focusing on how small and medium-sized enterprises can benefit from accessible software solutions. SWOT and PEST analyses are conducted to evaluate the benefits, risks, and limitations of digitalization, especially in the face of modern challenges such as military risks and inadequate infrastructure. Special attention is paid to the potential of digitalization in supporting sustainable development through data collection and reporting. The paper underscores the strategic importance of adapting integrated software solutions to enhance decision-making and operational transparency. It also identifies the challenges of integrating digital tools, such as high initial costs, lack of technical expertise, and the need for staff training. The study calls for further research into the development of multi-criteria approaches for selecting digital tools tailored to the specific needs of agricultural enterprises. This research contributes to the broader understanding of how digital technologies can transform accounting processes, offering insights into the balance between innovation, cost, and efficiency in the agricultural sector. The findings serve as a basis for future research and practical applications in optimizing accounting processes and fostering sustainable growth in agriculture.
ANALYSIS OF THE MARKET CONDITIONS FOR CYBERSECURITY PRODUCTS AND SERVICES
Authors:   National University "Odesa Law Academy", Savratskyi Oleksandr
Published: February 2025

This article is dedicated to analyzing the current state of the cybersecurity products and services market, its key trends, and the specific characteristics of supply and demand. It highlights critical challenges faced by Ukrainian companies in adopting effective cybersecurity measures, particularly the low readiness of small and medium-sized enterprises (SMEs) to invest in data protection. The study evaluates the dynamics of the global and Ukrainian cybersecurity markets, noting the rising frequency and complexity of cyber threats, especially amidst the full-scale invasion. The lack of systematic statistics, institutional mechanisms, and standards in Ukraine is identified as a significant barrier to the development of the sector. The research emphasizes the competitive advantages of Ukrainian specialists and companies, including their substantial contributions to the global cybersecurity industry. Ukrainian expertise has proven effective in addressing challenges such as DDoS attacks, malware protection, and incident response, showcasing the potential for integration into the international market. The study also analyzes the primary consumers of cybersecurity products and services, focusing on large and medium-sized businesses, critical infrastructure sectors, and industries such as finance, energy, and transportation. Recommendations are provided to enhance the efficiency of the cybersecurity market, including fostering innovation, improving public-private partnerships, and raising awareness among businesses about the importance of cybersecurity investments. Additionally, the potential for comprehensive "turnkey" solutions and educational initiatives to increase the overall cybersecurity culture within organizations is explored. This research concludes that cybersecurity is not only an economic necessity but also a strategic priority for Ukraine's stability and development, particularly in the face of escalating cyber threats. The findings underline the importance of continuous improvement in cybersecurity measures through technological advancement, regulatory updates, and proactive engagement with international best practices.
Pemberdayaan Masyarakat pada Usaha Mikro Kecil dan Menengah (UMKM) Melalui Pelatihan Branding Digital Marketing
Authors: Prajogi Liena
Published: February 2025

Pemberdayaan masyarakat pada sektor Usaha Mikro Kecil dan Menengah (UMKM) menjadi upaya strategis dalam meningkatkan perekonomian lokal dan kesejahteraan masyarakat Indonesia. Penelitian ini bertujuan untuk menganalisis efektivitas pelatihan branding melalui digital marketing terhadap pengembangan UMKM di Kampung Rawajati. Metode penelitian dengan menggunakan studi kasus kolaborasi pengabdian kepada masyarakat dalam rangka digitalisasi Kampung Rawajati melalui tutorial pada pre-test workshop tahap satu dan dua dengan melakukan pre-testdan post-test, dilanjutkan dengan final workshop untuk menggali secara mendalam pengalaman pelaku UMKM dalam mengadopsi strategi branding melalui kreatif pembuatan konten dan strategi promosi media sosial ini berhasil meningkatkan pemahaman pelaku UMKM tentang pentingnya citra merek dan pemanfaatan media digital dalam memasarkan produk. Peningkatan kemampuan ini berkontribusi pada peningkatan daya saing produk dan pertumbuhan penjualan. Selain itu, kolaborasi antara pemerintah, akademisi, dan komunitas lokal terbukti menjadi kunci keberhasilan pemberdayaan UMKM. Penelitian ini merekomendasikan keberlanjutan program pelatihan dan penguatan jaringan pemasaran berbasis digital menjadi solusi inovatif bagi pengembangan ekonomi masyarakat lokal secara berkelanjutan.
МУЛЬТИМОДАЛЬНЕ КОНСТРУЮВАННЯ ГРАФІЧНИХ НАРАТИВІВ В АВСТРАЛІЙСЬКОМУ ХУДОЖНЬОМУ ДИСКУРСІ (НА МАТЕРІАЛІ ГРАФІЧНОГО РОМАНУ ПЕТА ҐРАНТА “BLUE”)
Authors: Ставенко Олена Вікторівна
Published: February 2025

Наукову розвідку присвячено висвітленню особливостей творення австралійських графічних наративів, орієнтованих на дитячу і юнацьку читацьку аудиторію, що продемонстровано на матеріалі графічного роману Пета Ґранта “Blue”. Дослідження здійснено у контексті сучасної мультимодальної наратології з опертям на теорію графічного наративу як особливого гібридного типу наративу з візуальним і вербальним планами вираження, у яких історія та її темпоральність розгортається через простір, представлений в окремих панелях, що набувають свого значення лише у секвентивному поєднанні з іншими панелями й епізодами. Графічні наративи, створені в межах австралійської лінгвокультури, вирізняються втіленими візуально-вербально в елементах наративного конструювання смислами. Мета статті полягає в виявленні та характеристиці основних мультимодальних прийомів і засобів конструювання історії австралійських графічних наративів. Відповідно до цього, завданнями є продемонструвати особливості конструювання нарації, творення точки зору фокалізатора, постаті наратора, образів персонажів, а також художнього простору на прикладі графічного наративу Пета Ґранта “Blue”. У статті представлено результати мультимодального наратологічного аналізу конструювання графічних наративів, що характеризується секвентивним поєднанням наративних епізодів та панелей, які мають візуальний і вербальний модуси вираження, у єдиний наратив за допомогою особливої візуальної мови, наративних, часто кінематографічних, мультимодальних прийомів і засобів його творення. Виявлено, візуальні та візуально-вербальні засоби творення точки зору фокалізатора, мультимодальні засоби репрезентації наратора, його мовлення, думок і коментарів, особливості інтродукції різних образів персонажів, а також художнього простору, у якому втілюються глибокі імпліцитні смисли. Конструювання австралійських графічних наративів для дітей і юнацтва уможливлює розуміння читачами складних й амбівалентних тем і значень, представлених мультимодально. Творення художнього простору відбиває етнокультурні особливості австралійської мовної спільноти.
Career Development Challenges in the Judicial System of Indonesia: A Case Study of Judges and Registrars
Authors: Pratama Jefri , Hasyim Abdul Wahab , Alting Husen , Fahri Johan
Published: February 2025

The Constitutional Court and the Supreme Court of the Republic of Indonesia are the two high state institutions that possess judicial authority; they are both independent of other bodies of government. The Supreme Court, in particular, has two main types of human resources—judge (hakim) and Registrar (Panitera). Despite the fact that registrar and judge job descriptions are clearly different according to regulations, career paths indicate otherwise—while a judge can serve as a registrar at the Supreme Court level, a registrar cannot. This study examines career development inconsistencies in Indonesia’s judicial system, focusing on the dual roles of judges and registrars. Using a literature review approach, this paper highlights regulatory ambiguities and the urgent need for policy reform to address career progression challenges within the Supreme Court. This highlights the formation of a case that needs to be further explored by using a case study approach to unveil factors leading to this situation.
Hubungan Kualitas Udara Dan Kelembaban Udara Dengan Iritasi Mata Pada Pekerja Laki-Laki Di Proyek RS UPT Vertikal Makassar
Authors: Rahmadani Magfirah Anugrah , Masriadi  , Nur Ulmy Mahmud
Published: February 2025

Enviromental Protection Agency (EPA) Amerika Serikat menyatakan bahwa paparan polutan di luar ruangan 100 kali lebih tinggi daripada paparan polutan dalam ruangan karena tingginya konsentrasi polutan di luar ruangan. Indonesia sebagai salah satu negara di Asia yang berkembang menjadi negara industri baru juga menghadapi masalah polusi udara, dimana yang paling sering oleh asap kendaraan bermotor dan asap pabrik. Hasil emisi polutan CO2 di Sulawesi menunjukkan nilai tertinggi di wilayah Sulawesi selatan yaitu sebesar 84,4 sampai 103,7 ton dari tahun 2014 hingga tahun 2016. Jenis penelitian ini adalah kuantitatif dengan pendekatan cross sectional study. Dalam pengambilan sampel memakai probability sampling. Populasi penelitian ini ialah 200 orang pekerja bagian finishing di proyek RS UPT Vertikal Makassar. Data diperoleh dengan menggunakan lembar observasi dan wawancara. Metode analisis memakai analisis univariat dan bivariat dengan uji chi-square. Hasil penelitian ini menunjukkan bahwa ada hubungan antara Kualitas Udara PM 10 dengan Kelelahan Mata Pada Pekerja bagian Finishing di Proyek RS UPT Vertikal Makassar Tahun 2024 (p value=0,000 <0,05%). Saran dalam penelitian ini adalah Sebaiknya pekerja menggunakan kacamata safety pada saat melakukan pekerjaan untuk melindungi mata dari paparan debu dan partikel bahaya lainnya. Menggunakan kacamata safety juga merupakan langkah preventif yang penting untuk menjaga kesehatan dan keselamatan pekerja di tempat kerja.
Equity-based Financing and Credit Risk: A Monte Carlo Analysis of Economic Crises in Malaysia
Authors: Umul Ain’syah Sha’ari  , Siti Raihana Hamzah  , Karmila Hanim Kamil  , Putri Swastika
Published: February 2025

Financial instruments play a critical role in influencing the performance of a corporation. Corporate management may choose between debt and equity-based financing instruments to ensure the continuity of their business operations. Even so, the management will need to consider the credit risk exposure associated with the financing instruments as they tend to affect corporate performance, especially during an economic fluctuation. Therefore, this study employed Monte Carlo simulation to analyze and compare the credit risk exposure associated with debt and equity-based financing across various sectors in Malaysia, particularly in the context of significant economic crises. The sectoral data were used and segregated into two different phases of economic crises, which are from 2007 until 2018 (this period involves the Global Financial Crisis (GFC)) and from 2010 until 2021 (this period involves the COVID-19 pandemic). Through the simulation, this study finds that equity-based financing recorded consistent results of providing low credit risk exposure regardless of sectors and economic crises. Meanwhile, debt financing recorded high credit risk by all sectors during the economic crises. Therefore, this study suggests that equity-based financing is more reliable than debt in promoting corporate financial sustainability by offering lower exposure to credit risk and minimizing reliance on debt issuance.
Aerosol Measurement in Inpatients and Outpatients with SARS-CoV-2 Infection
Authors:   Department of Pediatrics, Division of Pneumology, Allergology, Infectious diseases and Gastroenterology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany, Landeis Anton , Rose Ume Emily , Lehmkühler Timon , Herrlich Laura , Hutter Martin , Schubert Ralf ,   Department of Pediatrics, Division of Pneumology, Allergology, Infectious diseases and Gastroenterology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany, Zielen Stefan ,   Respiratory Research Institute, Medaimun GmbH, 60596 Frankfurt am Main, Germany, Gutmann Desiree ,   Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
Published: February 2025

Background: Since the COVID-19 pandemic, research of aerosols and their importance for the transmission of SARSCoV-2 as well as their role in super-spreading events has intensified. The present study compared healthy controls,
outpatients with mild SARS-CoV-2 disease (outpatient group) and severely ill hospitalized patients (inpatient group) to
investigate the connection between aerosol production and disease severity.
Methods: For this purpose, the exhaled aerosol concentration of 234 adults (53 outpatients, 61 inpatients and 120
controls) was analyzed in a prospective clinical trial. The study consisted of a clinical examination, spirometry and aerosol
measurement using a spectrometer (Resp-Aer-Meter, Palas GmbH, Karlsruhe, Germany).
Results: The outpatients had a milder clinical course, fewer co-morbidities, and a lower age than the inpatient group. The
aerosol concentration of the groups differed significantly (p<0.001) from each other (median control 285.5 [14 - 850] n/l;
outpatient group 413 [18 - 7355] n/l and inpatient group 1353 [46 – 27779] n/l). The increase of aerosols was primarily
observed in the size range from 0.1 to 0.52 µm. Lung function differed significantly (p < 0.001) between the groups (median
FEV1; control group 87.6 [57.1 - 149.3], outpatient group 85.3 [50.3 - 117.6] % and inpatient group 59.7 [16.0 – 112.3]
%).
In this study, two super-emitters (3.8%) with very high aerosol exhalation (> 5000 n/l) could be identified among outpatients,
whereas 15.6% of the inpatients were super-emitters.
Conclusion: Aerosol measurement using the Resp-Aer-Meter is not suitable for detecting SARS-CoV-2 infections. However,
it could provide valuable information about super-emitters and may be used to support prevention and control measures
in the community.
EXPLORING HAIKU IN STUDENTS’ ENGLISH CREATIVE WRITING AT SMA NEGERI 7 KOTA KUPANG
Authors: Mega Sonya Kore , Marpaung Tiarma , Metboki Yakob
Published: February 2025

Getting challenged with academic writing, creative writing in a form of poetry can be delivered as an alternative task to help students cope with writing challenges. Haiku as one of the simplest poetry writings from Japan may help beginner writers to explore poetic words on certain objects or topics without using too many words in each line. Struggling writers can also use Haiku to stimulate their creative thinking in descriptive writing. With its simple pattern, Haiku can also boost students’ confidence to write. This study investigated whether students’ Haiku writing follows its rules and represents the qualities of creative writing. This qualitative study took 20 students in their third year of senior high school as research participants. This research used documentation as an instrument which is the students’ Haiku poetry writing. In the data analysis, students’ Haikus were assessed based on Haiku rules and the qualities of creative writing. It was found that most students have a sufficient understanding of the rules of Haiku writing. Students made some mistakes in their Haikus. However, students showed their efforts to perform the qualities of creative writing. Thus, the researchers believe that with consistent practices, students can write a qualified haiku as creative writing. More use of sensory words can further help the students to vary the diction and characterize the image described in their haikus. Finally, using haiku to express students’ feelings and thoughts and stimulate students’ creative writing is recommended in EFL classrooms.
TEACHER PROBLEMS IN THE IMPLEMENTATASI KURIKULUM MERDEKA: LITERATURE STUDY
Authors: Rahayu Jeni , Maghfiroh Ana
Published: February 2025

Curriculum is a plan designed to facilitate the teaching and learning process under the guidance and responsibility of a school or educational institution, including educators. Currently the implemented curriculum is the Kurikulum Merdeka. Learning tools, determining learning objectives, and conceptualizing the delivery of material are some of the problems found in the study of this research literature. The purpose of this study is to discuss further the problematic Implementasi Kurikulum Merdeka. This study using the literature review method with 7 article reference data sourced from Google Schoolar. Component the subject matter of discussion: 1) kinds of teacher problems, 2) Solution of teachers problem to implemented Kurikulum Merdeka 3) kind of methods used in research, 4) Subject of the research. Then the results of these questions: 1) teacher problem were teacher's difficulties in converting learning outcomes (LO) into appropriate learning objectives, lack of literacy materials, lack of learning media and the teacher's creativity to make class interesting, a lot of categories assessments, the teacher's lack of understanding of technology. Solutions offered to research data include: 2) the solution were teachers are active in participating in training and seminars on the independent curriculum so that they have broader insights and provisions for implementing the independent curriculum, teachers and school parties collaborate with supporting parties in implementing the independent curriculum, teachers must have a willingness to learn to upgrade themselves and adapt to technology. 3) the researchers often used qualitative studies case, 4) the subject of the researchers were Elementary School Teachers.
DESCRIPTIVE STUDY OF MODES AND TECHNIQUES OF INTERPRETING USED BY INTERPRETERS AT POTTER'S HOUSE CHRISTIAN MINISTRIES
Authors: Anakay Picessylia S. , Ludji Ifoni , Marpaung Tiarma
Published: February 2025

This study aims to identify and describe the modes and techniques used by interpreters in the process of interpreting sermons at Potter's House Christian Ministries. This research is a descriptive qualitative study. This research employed the scrutinizing method for data collection, which entails attentive listening to language usage (Sudaryanto, 1993: 133). The researcher adopted a non-participatory role, serving as mere observer of data without direct involvement in its formation. The study focused on analyzing language usage in two recorded videos of weekly services at Potter's House Christian Ministries. The researcher specifically examined individual sentences as manifestations of data, which were recorded and organized into tables based on criteria such as perspective, vocabulary, and modality. Technique assessment was employed to gather data and assess the impact of different modes and techniques on interpretation. The study reveals that interpreters at Potter's House Christian Ministries primarily employ consecutive interpreting mode, particularly short consecutive interpreting. The researcher also discovered six predominant techniques used during the interpretation process, namely: (1) reformulation, (2) elimination technique, (3) summarization, (4) error correction technique, (5) metaphors and saying technique, and (6) code-switching technique.
THE INFLUENCE OF THE PROBLEM-BASED LEARNING MODEL WITH PORTFOLIO ASSESSMENT OF SCIENTIFIC WRITING ABILITY BY STUDENTS’ COGNITIVE STYLE CONTROL
Authors: Tnunay Paulus
Published: February 2025

This research aims to determine the Influence of the Problem-Based Learning Model (PBM) with portfolio assessment on the ability to write scientific writing with variable cognitive style. The study employs an experiment with a posttest-only control group design. The sample is 66 students; it is taken randomly based on class. The research instrument is a test (rubric) of work performance and cognitive style. It is analyzed in one-way ANOVA. This research finds that 1) H1 is accepted because Fcount 22,964 (0,00) <0,05. It means there is a difference in the capability in scientific writing between the students who join the PBM model with portfolio assessment compared to those who join the conventional learning model; 2) H1 is accepted because Fcount 6,756 (0,012) <0,05. It means that after co-variable cognitive is controlled, there is a difference in scientific writing ability for those students that join the PBM Model with portfolio assessment compared with the students that join the conventional learning model; 3) H1 is accepted because Fcount 27,512 (0,000) <0,05. It means that covariable cognitive style significantly contributes to the capability in scientific writing at 30,1%. The rest is 69,9, which is contributed to another variables beyond this study
Representation of Political Identity in Billboard Advertisement: Linguistic Landscape Analysis in Kupang City
Authors: Benu Naniana N. , Denil Mauli , Prasetyo Lery
Published: February 2025

This study explores the political identity representation in billboard advertisements of the governor of NTT and the Mayor of Kupang candidates for the 2024-2029 period in Kupang City through the lens of linguistic landscape analysis. The research addresses three key aspects: the language employed in candidate billboards to shape political identity, the linguistic elements that reflect the candidates’ ideologies and political values, and the incorporation of local culture and languages to establish connections with the voters. Data was obtained using observation and documentation methods. Using qualitative analysis, this research reveals that the language and visual components of the billboards play a pivotal role in constructing the candidates' public personas, aligning political ideologies with the cultural and linguistic diversity of the region. The findings highlight the strategic use of local languages and cultural symbols, illustrating how these elements build rapport with voters and foster a sense of shared identity within the community.
The Application of the Sahm Rule to Determine the Likelihood of a Recession in 2025
Authors: Savino David M.
Published: February 2025

Over the decades a significant issue has been the degree to which expert analysts and economists have the ability to accurately predict the onset of a recession. The studies done to track trends and the early indicators of potential recessions have had mixed results that vary as much as the experts' opinions. However, one measure of predicting recessions has its supporters and proponents. The measure known as Claudia Sahm developed the Sahm Rule. This study is a twofold analysis of the Sahm Rule and its instrumentality in the analysis and predictions for the year 2025.
PENGARUH K3 (KESELAMATAN DAN KESEHATAN KERJA) DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN DI PT. SAIPEM INDONESIA KARIMUN YARD
Authors: Zhaflesia Zhetta Zhahiriyah , Dewi Aditya Mutiara , Febri Anti Rekha Dea
Published: February 2025

Tujuan penelitian ini adalah untuk mengetahui pengaruh K3 (Keselamatan dan Kesehatan Kerja) dan lingkungan kerja terhadap kinerja karyawan yang ada di PT. Saipem Indonesia Karimun Yard. Populasi dalam penelitian adalah karyawan  yang ada di PT. Saipem Indonesia Karimun Yard. Respoden dalam penelitian ini sebanyak 100 orang. Pengambilan sampel dilakukan dengan menggunakan teknik purposive sampling. Pengumpulan data dilakukan dengan menggunakan data primer melalui kuesioner menggunakan skala likert untuk mengukur 16 pernyataan indikator.Teknik analisis data menggunakan metode kuantitatif, Pengolahan data menggunakan  aplikasi  SPSS 25.0. Analisis data menggunakan teknik analisis regresi linear, uji t, uji f. Hasil penelitian menunjukan bahwa pengaruh Keselamatan dan Kesehatan Kerja (K3) dan lingkungan kerja secara bersama-sama berpengaruh terhadap kinerja karyawan. Dari hasil pembahasan, dapat ditarik kesimpulan bahwa K3 (Keselamatan dan Kesehatan Kerja) dan lingkungan kerja di PT. Saipem Indonesia Karimun Yard bisa dikatakan baik, serta dapat dipertahankan untuk program dan usaha yang telah dilaksanakan.
LACVD growth of diamond on gallium nitride substrates with PH3 in recipe
Authors: Mallik Awadesh Kumar , Sankaran Kamatchi Jothiramalingam , Desta Derese , Pobedinskas Paulius , Joy Rani Mary , Rouzbahani Rozita , Lloret Fernando , Boyen Hans-Gerd , Haenen Ken
Published: February 2025

Integrating chemical vapour deposition (CVD) diamond with GaN material for effective thermal management of the power electronic devices is critical. However, there are issues with CVD processing, like GaN substrate etching under normal CVD diamond growth conditions, which nowadays, is overcome by inserting an intermediate silicon nitride layer of very low thermal conductivity. Unfortunately, such a buffer layer is detrimental to proper heat dissipation. So, the direct growth of diamonds onto GaN substrates is still a relevant research topic. Here, we have used an innovative low-temperature growth process by linear antenna microwave plasma enhanced CVD to overcome such a problem. Other than the normal hydrogen gas CVD recipe, PH3 gas diluted with hydrogen (1,000 ppm in H2) was added as a doping gas precursor, to dope the diamond lattice with phosphorous atoms, by varying the substrate temperature from 400oC to 900oC. PH3 addition in the precursor gas recipe was found to etch the GaN substrate substantially. The phosphorous atom was found to be present on the surface of the diamond film from their corresponding X-ray photoelectron spectroscopy signal. Raman spectroscopy and scanning electron microscopy images do not reveal GaN substrate damage when pure hydrogen gas was used as a precursor without PH3 addition. However, there is a relative competition between the GaN substrate decomposition and CVD diamond growth rates when diluted PH3 gas was used in the precursor gas recipe. At a lower substrate temperature of 400oC, GaN etching was prevalent, but with a gradual increase in substrate temperature to 900ºC, diamond lateral growth was promoted inside the linear antenna CVD reactor, which partially protected the underneath GaN/sapphire heterostructures from decomposition under harsh plasma CVD conditions.
A geographic information systems selection approach to repurposing offshore oil & gas assets for green hydrogen production
Authors: Rupp William , Rabea Karim , Yuan Ruoyang
Published: February 2025

Integrating green hydrogen production with existing oil and gas infrastructure is seen as viable step for the reutilization of oil and gas assets. Green hydrogen production through offshore wind has the potential to extend the lives of these systems, reduce decommissioning costs and provide a source of clean energy. This paper presents an outlook on wind license areas using existing oil and gas infrastructure. Three scenarios are proposed for the conversion of offshore assets into wind turbine sites, including the conversion of a platform into a substation. A methodology is provided to assess the suitability of offshore wind using exclusion criteria and the cessation of production dates for oil and gas infrastructure. This methodology is applied to the UK Exclusive Economic Zone (EEZ), and the results show that 7.4% of the UK EEZ is within the top suitability index for wind turbine development. The cost of green hydrogen production from different offshore locations is estimated to be in the range of 9.78–11.76 £/kgH2 depending on the wind farm scale and the distance. The study highlights the potential for using existing infrastructure for wind turbine development and provides valuable insights for stakeholders in the energy industry.
Advances in the detection of biomarkers for ischemic stroke
Authors: Liang Ying , Chen Juan , Chen Yue , Tong Yaoyao , Li Linhao , Xu Yuan , Wu Shimin
Published: February 2025

Ischemic stroke is a leading cause of mortality and morbidity globally. Prompt intervention is essential for arresting disease progression and minimizing central nervous system damage. Although imaging studies play a significant role in diagnosing ischemic stroke, their high costs and limited sensitivity often result in diagnostic and treatment delays. Blood biomarkers have shown considerable promise in the diagnosis and prognosis of ischemic stroke. Serum markers, closely associated with stroke pathophysiology, aid in diagnosis, subtype identification, prediction of disease progression, early neurological deterioration, and recurrence. Their advantages are particularly pronounced due to their low cost and rapid results. Despite the identification of numerous candidate blood biomarkers, their clinical application requires rigorous research and thorough validation. This review focuses on various blood biomarkers related to ischemic stroke, including coagulation and fibrinolysis-related factors, endothelial dysfunction markers, inflammatory biomarkers, neuronal and axonal injury markers, exosomes with their circular RNAs and other relevant molecules. It also summarizes the latest methods and techniques for stroke biomarker detection, aiming to provide critical references for the clinical application of key stroke biomarkers.
Evaluating diabetes-related nutrition knowledge and dietary beliefs among type 2 diabetes patients in Vidarbha region, Maharashtra: a mixed method approach for insightful analysis
Authors: Kawalkar Umesh , Mankar Amar , Puri Mahesh , Singh Anshu , Telrandhe Shital , Gaidhane Abhay , Talapalliwar Manoj , Fuladi Sayali
Published: February 2025

Introduction

The purpose of this study is to evaluate diabetes-related nutrition knowledge and dietary beliefs among Type 2 Diabetes Mellitus (T2DM) patients in the Vidarbha region, Maharashtra, utilizing a mixed method approach. The study aims to assess the existing gaps in nutritional education and dietary practices among T2DM patients, with a specific focus on understanding gender-based differences in knowledge levels.

Methods

A convergent parallel mixed method approach was employed at tertiary care hospital in Vidarbha region, over 18 months. Participants aged 30 years and above, diagnosed with T2DM for at least 6 months, were included. Quantitative data collection utilized structured questionnaires during interviews to assess socio-demographic characteristics and diabetes-related nutrition knowledge. Qualitative data collection involved in-depth interviews to explore participants’ perspectives on dietary beliefs and practices, ensuring ethical approval and informed consent.

Results

Total 384 T2DM patients participated, revealing significant gender disparities in diabetes-related nutrition knowledge. Male participants exhibited higher awareness levels across various aspects of dietary recommendations. Quantitative analysis highlighted gender differences in knowledge regarding recommended fruit and vegetable intake, milk product consumption, types of fruits suitable for diabetics, inclusion of rice in diabetic diets, alcohol consumption, and recommended salt intake. Qualitative analysis identified key themes related to food choices, meal timing, portion control, dietary restrictions, and cultural influences.

Conclusion

The study emphasizes gender-sensitive educational interventions to enhance diabetes-related nutrition knowledge and self-management practices among T2DM patients. Tailored interventions addressing gender-based knowledge gaps are crucial for improving diabetes management outcomes and overall health among T2DM patients in Vidarbha, Maharashtra.
The post-orchiectomy systemic inflammatory index is associated with tumor characteristics in clinical stage I germ cell tumors
Authors: Lesko Peter , Mego Michal
Published: February 2025

Background

Approximately 25% to 30% of clinical stage I (CSI) germ cell cancer (GCT) patients will experience disease relapse after an orchiectomy. Adding adjuvant treatment will decrease the relapse rate but could lead to over-treatment. Prognostic biomarkers such as lymphovascular invasion (LVI) and/or embryonal carcinoma (EC) in non-seminoma (NSGCT) and rete testis invasion (RTI) and/or primary tumor size (PTS) in seminoma (SGCT) add limited value in treatment decision- making. The aim of this study is to assess the systemic inflammatory index (SII) and lactate-dehydrogenase (LDH) with clinicopathological findings along with their prognostic impact.

Methods

This is a retrospective study that included 159 diagnosed CSI GCT patients, who underwent active surveillance (AS) from June 2004 to November 2023. Medical records and pathology reports were collected retrospectively. Drawn blood must have been done less than 3 months after the orchiectomy had been done. For the survival analysis, we used dichotomized values of the studied biomarkers from “low” to “high” based on the median values.

Results

The median follow-up time was 61 months (ranging from 1 to 230 months), with 2-year relapse- free survival (RFS) of 81.3% and 69.0% in SGCT and NSGCT, respectively. We confirm inferior RFS in the presence of LVI compared to an absence of LVI in NSGCT ([HR]= 2.59, 95%CI (0.74-9.07), p=0.04). A trend of inferior RFS in NSGCT patients with EC predominance (≥50%) was also observed ([HR]= 2.59, 95%CI (0.98-6.85), p=0.06). A prognostic impact of RTI and a PTS >4cm in SGCT was not observed with p=0.24 and p=0.51, respectively. The SII was assessed in the population, and a higher neutrophil- to- lymphocyte ratio (NLR) value was associated with LVI presence and with advanced tumor stage in NSGCT. In SGCT, a higher SII level was associated with LVI presence and advanced pathological stage. A PTS >4cm was associated with a higher LDH level among all the studied patients, without significance in SGCT or NSGCT. A higher LDH value in NSGCT was also associated with EC predominance (≥50%).

Conclusion

Our study, for the first time, revealed associations of post-orchiectomy systemic inflammatory indices and/or LDH in CSI GCT. These new associations deserve further evaluation in a larger cohort of patients with CSI GCT to elucidate whether its associations in certain histology subgroups will improve the stratification of the at-risk population.
Association between human leukocyte antigen E expression and outcomes in solid tumors: a systematic review and meta-analysis
Authors: Benitez Fuentes Javier David , Bartolome Arcilla Jorge , Lazaro Sanchez Antonio David , de Luna Aguilar Alicia , Mohamed Mohamed Kauzar , Guevara-Hoyer Kissy , Ballestin Martinez Pablo , Borregon Rivilla Miguel , Ferrandez Arias Asia , Sánchez-Ramon Silvia , Ocaña Alberto
Published: February 2025

Background

Immunotherapy has gained momentum with the discovery of novel antibodies targeting immunosuppressive proteins. HLA-E, a non-classical major histocompatibility complex class I (MHC-I) protein, exhibits immunosuppressive properties, potentially influencing tumor immune evasion mechanisms. The association between Human Leukocyte Antigen E (HLA-E) expression and outcomes in solid tumors remains unclear.

Methods

A systematic review of MEDLINE, Scopus, and the Cochrane Library up to March 15, 2024, was conducted following the PRISMA guidelines. Studies investigating HLA-E expression in solid tumors and its association with OS and DFS were included. Statistical analysis was performed using Comprehensive Meta-Analysis (version 3.0) with random-effects models.

Results

After screening 657 articles, 11 studies were included, comprising a total of 1781 patients. The studies encompassed a variety of cancer types, follow-up periods, and staging details, with the majority focusing on non-metastatic cases. Notably, three studies evaluated colorectal cancer, while others focused on pancreatic, esophageal, brain, renal cell, gastric, endometrial, cervical, and hepatocellular carcinomas. The mean age of the patients was 59.81 ± 2.01 years, and the median follow-up period was 57.45 ± 8.91 months. HLA-E expression demonstrated no statistically significant association with OS (HR 0.913, 95% CI = 0.567-1.469; P=0.707), with significant heterogeneity observed (I2 = 84%). However, HLA-E non-expression was significantly associated with improved DFS (HR 1.406, 95% CI = 1.027-1.930; P=0.03), with moderate heterogeneity (I2 = 45%).

Conclusion

This systematic review highlights that HLA-E expression in solid tumors could be a biomarker of better prognosis, measured by DFS. These findings align with the clinical benefit observed for agents targeting this pathway. However, further studies should be performed to confirm these preliminary observations.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024527598, identifier CRD42024527598.
Efficacy and prognostic impact of preoperative risk factors for salvage liver transplantation and repeat hepatectomy in patients with early-stage recurrent hepatocellular carcinoma: a propensity score-matched analysis
Authors: Yang Linfeng , Huang Yang , Deng Dawei , Liu Junning , Xu Liangliang , Yi Pengsheng
Published: February 2025

Background

The optimal treatment strategy for recurrent hepatocellular carcinoma (rHCC) remains unclear. This study is based on cases of rHCC after liver resection, aiming to evaluate the influence of preoperative risk factors on the long-term prognosis of patients with rHCC by comparing patients who underwent salvage liver transplantation (SLT) with those who underwent repeat hepatectomy (RH).

Methods

We retrospectively analyzed 401 consecutive patients with rHCC who underwent SLT or RH between March 2015 and December 2022. Next, we performed propensity score matching, subgroup analyses, and both univariate and multivariate analyses. In addition, Kaplan–Meier analysis was used to estimate the overall survival (OS) and recurrence-free survival (RFS) after recurrence.

Results

The 1-, 3-, and 5-year OS and RFS rates in the SLT group were significantly higher than those in the RH group (p=0.0131 and p=0.0010, respectively), and similar results were observed after propensity score matching. In the presence of zero or one risk factors, the OS and RFS in the SLT group were significantly better than those in the RH group (p=0.0386 and p=0.0117, respectively). However, in the presence of two to four risk factors, no significant differences in OS or RFS were detected between the two groups (p=0.1119 and p=0.1035, respectively).

Conclusion

Our analysis identified a number of risk factors that were strongly correlated with a long term prognosis for patients with rHCC who underwent SLT and RH: multiple tumors, a maximum tumor diameter ≥5 cm, microvascular invasion, and a recurrence time ≤2 years. Our findings provide important reference guidelines for organ allocation and clinical decision-making.
Role of artificial intelligence in pediatric intensive care: a survey of healthcare staff perspectives in Saudi Arabia
Authors: Al-Sofyani Khouloud Abdulrhman
Published: February 2025

Background

Artificial Intelligence (AI) has the potential to revolutionize Pediatric Intensive Care Units (PICUs) by enhancing diagnostic accuracy, improving patient outcomes, and streamlining routine tasks. However, integrating AI into PICU environments poses significant ethical and data privacy challenges, necessitating effective governance and robust regulatory frameworks to ensure safe and ethical implementation. This study aimed to explore valuable insights into healthcare professionals' current perceptions and readiness to adopt AI in pediatric critical care, highlighting the opportunities and challenges ahead.

Methods

A cross-sectional study conducted an online survey among healthcare practitioners at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. The survey included questions about professional roles, experience, and familiarity with AI, their opinions on AI's role, trust in AI-driven decisions, and ethical and privacy concerns. Statistical analyses were performed using IBM SPSS.

Results

Results found varying familiarity with AI among healthcare professionals, with many expressing limited knowledge of AI applications in PICU settings. Despite this, there was growing recognition of AI's current applications. Trust in AI-driven decisions for PICU management was mixed, with most expressing partial trust. Opinions on AI's role in enhancing diagnostic accuracy and improving patient outcomes varied. Ethical considerations, data privacy, and effective governance to address regulatory and ethical challenges were highlighted as critical concerns.

Conclusion

Healthcare practitioners in the PICU preferred using AI for routine patient monitoring but had concerns about its use in diagnoses and advanced healthcare. Concerns were held regarding data privacy, security breaches, and patient confidentiality.
Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability
Authors: Moestl Stefan , De Boni Laura , Hoenemann Jan-Niklas , Kramer Tilmann , Schmitz Jan , Pesta Dominik , Frett Timo , Bohmeier Maria , Frings-Meuthen Petra , Ewald Ann Charlotte , Nitsche Andrea , Loehr Patricia , Noppe Alexandra , Klischies Nicolas , Huang Alex S. , Laurie Steven S. , Marshall-Goebel Karina , Macias Brandon R. , Tank Jens , Jordan Jens , Mulder Edwin
Published: February 2025

After longer duration space missions, some astronauts experience structural and functional changes in the eye and structural changes in the brain, termed Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Countermeasures against SANS are required to minimize potential operation impacts and negative long-term health consequences. Headward fluid shifts, which appear to promote SANS, provide a target for countermeasures. The SANS countermeasures study, a 30 days strict head down tilt bed rest (HDTBR) study, tested two mechanical countermeasures aimed at reversing cephalad fluid overload. This work presents design and methodology of the study with a focus on countermeasure implementation and tolerability. Following baseline evaluations, participants were randomized to four groups and HDTBR commenced: Daily application of 25 mmHg lower body negative pressure for 6 h, six-hour bilateral venous constrictive thigh cuffs following moderate cycling exercise on 6 days per week, a negative control group without countermeasures, and a positive control group with HDTBR interruption for 6 h per day by sitting upright. The potential of these countermeasures for future space applications was examined in 86 different experiments, which will be reported elsewhere. Comfort ratings ranging from 1 (very uncomfortable) to 5 (very comfortable) were used to asses tolerability. Overall, 47 participants (20 women) completed the study. Out of 4,032 h scheduled for both countermeasures, 10.5 h were not performed due to medical issues unrelated to the countermeasures. Mean comfort ratings were 3.9 in men and 4.4 in women in the lower body negative pressure group (p = 0.1356) and 4.2 in men and 3.9 in women in the thigh cuff group (p = 0.1604). We conclude that both countermeasures were well tolerated and applied under well controlled conditions, thus, allowing for meaningful analyses of efficacy in attenuating HDTBR effects.
Acute effects of caffeine and paracetamol on velocity and power in resistance exercise
Authors: Scapec Bela , Grgic Jozo , Varovic Dorian , Mikulic Pavle
Published: February 2025

This study aimed to explore the isolated and combined effects of caffeine and paracetamol (acetaminophen) on velocity and power in resistance exercise. Twenty-eight resistance-trained men and women participated in this randomized, double-blind, placebo-controlled, crossover study. The participants performed three sets of the bench press with 75% of one-repetition maximum to momentary muscular failure after ingesting a placebo, caffeine (3 mg/kg), paracetamol (1,500 mg), or caffeine + paracetamol 45 min before exercise. Velocity and power of the repetitions in each set were analysed. Compared to placebo, only isolated caffeine ingestion increased mean velocity (d = 0.34), and mean power (d = 0.17) in the first set. No significant differences between the conditions were observed for any of the analysed outcomes in the second and third sets. Our results indicate that only isolated caffeine ingestion improves velocity and power in resistance exercise, even though these effects are not consistent across all sets. Paracetamol ingestion was not ergogenic, even when combined with caffeine. These results highlight that analgesics may be ineffective in improving resistance exercise performance.