bluuebunny/crossref_metadata_2025 huggingface dataset:
Brahmā at the Ajapāla Banyan Tree: Re-Examining Paintings at the Sulamani Temple, Bagan
Authors: Bopearachchi Osmund
Published: April 2020

This article examines how the literary evidence corroborates with the visual evidence for the unusual presence of Brahmā with the Buddha at the Ajapāla banyan tree of the goatherd symbolizing the Fifth of the Seven Weeks after the Enlightenment of the Buddha in the paintings of the recessed chamber in the east corridor of the Sulamani temple in Bagan in Burma. The presence of Brahmā at the Ajapāla banyan tree is puzzling, because most of the mural paintings in Burma and Sri Lanka follow the chronological order given in the Nidānakathā, and, as a result, the intervention of Brahmā pleading with the Buddha to reconsider his decision not to expound the doctrine takes place in the Eighth Week. The painting of the encounter of Brahmā and the Buddha at the banyan tree in the Sulamani temple in the Fifth Week is thus a notable exception. It is argued that the visual artist of the Sulamani temple who introduced Brahmā in an earlier than normal context knew the narratives in the Pāli Mahāvagga and in the Nidānakathā well and, to shorten a long story, selected quite wisely the Ajapāla banyan tree of the goatherd where both events took place, meaning the Fifth and Eighth Weeks.
A Novel Divergent Geminivirus Identified in Asymptomatic New World Cactaceae Plants
Authors: Fontenele Rafaela S. , Salywon Andrew M. , Majure Lucas C. , Cobb Ilaria N. , Bhaskara Amulya , Avalos-Calleros Jesús A. , Argüello-Astorga Gerardo R. , Schmidlin Kara , Khalifeh Anthony , Smith Kendal , Schreck Joshua , Lund Michael C. , Köhler Matias , Wojciechowski Martin F. , Hodgson Wendy C. , Puente-Martinez Raul , Van Doorslaer Koenraad , Kumari Safaa , Vernière Christian , Filloux Denis , Roumagnac Philippe , Lefeuvre Pierre , Ribeiro Simone G. , Kraberger Simona , Martin Darren P. , Varsani Arvind
Published: April 2020

Cactaceae comprise a diverse and iconic group of flowering plants which are almost exclusively indigenous to the New World. The wide variety of growth forms found amongst the cacti have led to the trafficking of many species throughout the world as ornamentals. Despite the evolution and physiological properties of these plants having been extensively studied, little research has focused on cactus-associated viral communities. While only single-stranded RNA viruses had ever been reported in cacti, here we report the discovery of cactus-infecting single-stranded DNA viruses. These viruses all apparently belong to a single divergent species of the family Geminiviridae and have been tentatively named Opuntia virus 1 (OpV1). A total of 79 apparently complete OpV1 genomes were recovered from 31 different cactus plants (belonging to 20 different cactus species from both the Cactoideae and Opuntioideae clades) and from nine cactus-feeding cochineal insects (Dactylopius sp.) sampled in the USA and Mexico. These 79 OpV1 genomes all share > 78.4% nucleotide identity with one another and < 64.9% identity with previously characterized geminiviruses. Collectively, the OpV1 genomes display evidence of frequent recombination, with some genomes displaying up to five recombinant regions. In one case, recombinant regions span ~40% of the genome. We demonstrate that an infectious clone of an OpV1 genome can replicate in Nicotiana benthamiana and Opuntia microdasys. In addition to expanding the inventory of viruses that are known to infect cacti, the OpV1 group is so distantly related to other known geminiviruses that it likely represents a new geminivirus genus. It remains to be determined whether, like its cactus hosts, its geographical distribution spans the globe.
Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses
Authors: Woelfl Franziska , Léger Psylvia , Oreshkova Nadia , Pahmeier Felix , Windhaber Stefan , Koch Jana , Stanifer Megan , Roman Sosa Gleyder , Uckeley Zina M. , Rey Felix A. , Boulant Steeve , Kortekaas Jeroen , Wichgers Schreur Paul J. , Lozach Pierre-Yves
Published: April 2020

The sand fly-borne Toscana virus (TOSV) is the major cause of human meningoencephalitis in the Mediterranean basin during the summer season. In this work, we have developed a T7 RNA polymerase-driven reverse genetics system to recover infectious particles of a lineage B strain of TOSV. The viral protein pattern and growth properties of the rescued virus (rTOSV) were found to be similar to those of the corresponding wild-type (wt) virus. Using this system, we genetically engineered a TOSV mutant lacking expression of the non-structural protein NSs (rTOSVɸNSs). Unlike rTOSV and the wt virus, rTOSVɸNSs was unable to (i) suppress interferon (IFN)-b messenger RNA induction; and (ii) grow efficiently in cells producing IFN-b. Together, our results highlight the importance of NSs for TOSV in evading the IFN response and provide a comprehensive toolbox to investigate the TOSV life cycle in mammalian and insect host cells, including several novel polyclonal antibodies.
Using Next Generation Sequencing to Study the Genetic Diversity of Candidate Live Attenuated Zika Vaccines
Authors: Collins Natalie D. , Shan Chao , Nunes Bruno T.D. , Widen Steven G. , Shi Pei-Yong , Barrett Alan D.T. , Sarathy Vanessa V.
Published: April 2020

Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. Candidate live-attenuated vaccine (LAV) viruses with engineered deletions in the 3’ untranslated region (UTR) provide immunity and protection in animal models of ZIKV infection, and phenotypic studies show that LAVs retain protective abilities following in vitro passage. The present study investigated the genetic diversity of wild-type (WT) parent ZIKV and its candidate LAVs using next generation sequencing analysis of five sequential in vitro passages. The results show that genomic entropy of WT ZIKV steadily increases during in vitro passage, whereas that of LAVs also increased by passage number five but was variable throughout passaging. Additionally, clusters of single nucleotide variants (SNVs) were found to be present in the pre-membrane/membrane (prM), envelope (E), nonstructural protein NS1 (NS1), and other nonstructural protein genes, depending on the specific deletion, whereas in the parent WT ZIKV, they are more abundant in prM and NS1. Ultimately, both the parental WT and LAV derivatives increase in genetic diversity, with evidence of adaptation following passage.
Utility of Healthcare System-Based Interventions in Improving the Uptake of Influenza Vaccination in Healthcare Workers at Long-Term Care Facilities: A Systematic Review
Authors: Bechini Angela , Lorini Chiara , Zanobini Patrizio , Mandò Tacconi Francesco , Boccalini Sara , Grazzini Maddalena , Bonanni Paolo , Bonaccorsi Guglielmo
Published: April 2020

Healthcare workers (HCWs) in long-term care facilities (LTCFs) can represent a source of influenza infection for the elderly. While flu vaccination coverage (VC) is satisfactory in the elderly, HCWs are less likely to be vaccinated. There is no definitive evidence on which types of healthcare system-based interventions at LTCFs would be more useful in improving the vaccination uptake among HCWs. We performed a systematic review in different databases (Pubmed, Cochrane Database of Systematic Reviews, Health Evidence, Web of Science, Cinahl) to provide a synthesis of the available studies on this topic. Among the 1177 articles screened by their titles and abstracts, 27 were included in this review. Most of the studies reported multiple interventions addressed to improve access to vaccination, eliminate individual barriers, or introduce policy interventions. As expected, mandatory vaccinations seem to be the most useful intervention to increase the vaccination uptake in HCWs. However, our study suggests that better results in the vaccination uptake in HCWs were obtained by combining interventions in different areas. Educational campaigns alone could not have an impact on vaccination coverage. LTCFs represent an ideal setting to perform preventive multi-approach interventions for the epidemiological transition toward aging and chronicity.
Acupuntura, a utilização moderna de uma tradição milenar
Authors: Filho Reginaldo de Carvalho Silva
Published: April 2020

.
Bridging Audio and Augmented Reality towards a new Generation
of Serious Audio‑only Games
Authors: Rovithis Emmanouel , Floros Andreas , Moustakas Nikos , Vogklis Konstantinos , Kotsira Lily
Published: April 2020

Abstract: Educational practices are constantly adjusting to
technological advances, in order to improve their effectiveness in
delivering knowledge and preparing students for the challenges of
modern digital society. Electronic games and augmented reality
environments are two such media that can shape powerful modes of
interactive and immersive experiences. Audio games in particular,
i.e. electronic games that utilise data sonification and audio
interaction techniques to express all narrative and gameplay
content, have been proven to enhance players’ skills, such as
concentration, memory, fantasy, emotional response, perception, data
management and cooperation. However, despite the promising research
findings reported in literature, there has been no systematic
approach in integrating systems based on audio interaction into
formal education. This article suggests that audio games can be
designed and implemented for the delivery of targeted curricula
through an engaging learning experience, whereas fusing audio game
mechanics into new interactive technologies, such as augmented
reality environments, will further enhance the students’
immersiveness in the learning process. Towards establishing the
theoretical framework for the design of educational audio games, as
well as educational augmented reality audio games, the authors
review existing approaches and argue that the inherent features of
both audio interaction and augmented reality systems agree with the
official educational goals formulated by the Greek Ministry of
Education and the International Baccalaureate Institution. Then,
they discuss four original projects in terms of sound and mechanics
design to demonstrate that audio games can address a wide range of
subjects, adopt cross‑curricular strategies, facilitate complex
modes of interaction, and realise creative, collaborative and
inclusive learning activities.
The Gameplay Loop Methodology as a Tool for Educational Game
Design
Authors: Czauderna André , Guardiola Emmanuel
Published: April 2020

The field of game design for educational content lacks a
focus on methodologies that merge gameplay and learning. Existing
methodologies typically fall short in three ways: they neglect the
unfolding of gameplay through players’ actions over a short period
of time as a significant unit of analysis; they lack a common
consideration of game and learning mechanics; and they falsely
separate the acts of playing and learning. This paper recommends the
gameplay loop methodology as a valuable tool for educational game
design, as it addresses these major shortcomings. Furthermore, this
paper outlines how this methodology can be supported by knowledge
from subject‑specific didactics—considering both the curriculum and
its mediation (contributed by experts from educational practice) as
well as methods of player‑centered design—in order to ensure the
appropriateness of learning objectives and techniques of mediation
in the context of a particular field of knowledge, the game’s appeal
to its target group, and the effectiveness of the learning
mechanics. A case study of the design and production phases of
Antura and the Letters, a literacy game for Arabic refugee children,
illustrates the uses of the gameplay loop methodology situated in
the described broader approach to educational game design. Finally,
this paper explains the results of an impact study revealing that
the approach indeed provides the opportunity to merge playing and
learning.
Pengaruh Waktu dan Suhu terhadap Proses Pengeringan Bawang Merah menggunakan Tray Dryer
Authors: Manfaati Rintis , Baskoro Hibah , Rifai Muhammad Muhlis
Published: April 2020

Peningkatan produksi bawang merah akan membuat stok melimpah dan harga bawang merah akan turun. Produk olahan bawang merah bertujuan untuk memperpanjang daya simpan dan meningkatkan nilai tambah. Salah satu metoda pengolahan dan pengawetan makanan adalah melalui pengeringan. Tujuan dari penelitian ini adalah untuk mengetahui suhu dan waktu pengeringan optimum serta laju pengeringan bawang merah menggunakan Tray dryer. Pada penelitian ini  suhu pengeringan divariasikan  pada range 50 -70oC, waktu pengeringan pada range 4-8 jam dan laju udara pengeringan 2,0 m/s . Analisis yang dilakukan terhadap produk adalah nilai kadar air menggunakan metode Gravimetri, kadar abu menggunakan metode pengabuan langsung/kering, dan kadar protein menggunakan metode Kjehdahl. Hasil penelitian menunjukkan bahwa suhu optimum pengeringan bawang merah menggunakan Tray dryer adalah 70˚C dan waktu optimum pengeringan adalah 7 jam. Produk pengeringan memiliki nilai kadar air sebesar 4%, kadar abu 3,95%, dan kadar protein 2,3%.
Modifikasi Homopolimer Poli (Vinil Asetat) dengan Variabel Hidrofobisitas Emulsifier untuk Aplikasi Perkayuan
Authors: Sihombing Rony Pasonang , Ngatin Agustinus
Published: April 2020

Perekat (lem) merupakan salah satu media yang sangat penting untuk menyatukan kayu yang satu dengan lainnya dan berbasis pada pelarut. Umumnya, pelarut yang digunakan adalah pelarut organik golongan BTX (Benzena, Toluene, dan Xylene) yang merupakan pelarut berbahaya bagi lingkungan dan kesehatan. Untuk itu perekat berbasis air yang berbahan baku vinil asetat akan diperkenalkan pada penelitian ini. Pengaruh hidrofobisitas surfaktan yang digunakan terhadap viskositasnya dijadikan tujuan dari penelitian ini. Vinil asetat dan polivinil alkohol digunakan sebagai bahan baku. Asam tartrat dan amonium persulfat digunakan sebagai bahan pendukung proses. Proses polimerisasi dilakukan di dalam reaktor dilengkapi kondensor, termometer, dan motor pengaduk dengan laju 50 – 500 rpm (opsional, hingga terbentuk vorteks). Water bath dipanaskan pada tekanan 1 atm dan suhu sekitar 750C. Perekat yang dihasilkan dilakukan uji viskositas dan total NVC . Hasil penelitian adalah sintesis perekat melalui proses polimerisasi vinil asetat dengan polivinil alkohol berhasil dibuat, dengan hasil perekat tanpa menggunakan surfaktan memiliki viskositas (13.400 cps) di antara NP-10 (14.500 cps) dan NP-06 (5.500 cps), sehingga perekat dengan surfaktan NP-10 memiliki viskositas paling tinggi dengan nilai 14.500 cps dari ketiga perekat yang dihasilkan.
THE RELATIONSHIP BETWEEN SELF EFFICACY AND MOTIVATION WITH STEM EDUCATION: A SYSTEMATIC LITERATURE REVIEW
Authors: Wan Jaafar Wan Naliza , Maat Siti Mistima
Published: April 2020

While Malaysia’s performance in the international assessment such as TIMSS and PISA are inclined to worry, enrollment of students in the science stream is also decreasing. Even though there are rapid changes made into the curriculum, teaching strategies and assessment method, the quality of Malaysia’s education system especially in mathematics have not shown any promising changes. The purpose of this study is to analyze previous studies on the relationship between students’ self-efficacy and motivation with STEM education. This systematic review is conducted by qualitatively analyzed 34 articles from Scopus, Google Scholar and MyJurnal using thematic analysis. The result of the analysis is categorized into six themes: non-cognitive factors, pedagogy, STEM intervention programs, social-economic status, teachers’ gender, and mathematics curriculum. The result shows that self-efficacy and motivation are highly affected by mathematics achievement. This paper suggesting a rapid study on STEM education at the primary school level so that issues related to mathematics achievement can be solved at an earlier stage.
Soil Erosion and Sediment Deposition Modelling at the Small Catchment Scale
Authors: Vysloužilová Barbora , Kliment Zdeněk
Published: April 2020

Water erosion is considered to be the most important factor behind the degradation of agricultural land. Many methods of measuring soil erosion processes, using mathematical models, have been developed in recent years. The most widespread of these, USLE, and its modifications have been used as the basis for new erosion models. Two such models, USPED (Mitášová et al. 1996) and WaTEM/SEDEM (Van Rompaey et al. 2001; Van Oost et al. 2000; Verstraeten et al. 2002), have been utilized to study erosion and deposition processes in the experimental rural catchment of Černičí. River sediment transport is also calculated using the WaTEM/ SEDEM model. The results are discussed with results from USLE and a field survey. The article also presents brief instructions for implementing the models in a GIS environment.
Examination of the relationship between viscoelastic properties and the invasion of ovarian cancer cells by atomic force microscopy
Authors: Chen Mengdan , Zeng Jinshu , Ruan Weiwei , Zhang Zhenghong , Wang Yuhua , Xie Shusen , Wang Zhengchao , Yang Hongqin
Published: April 2020

The mechanical properties of cells could serve as an indicator for disease progression and early cancer diagnosis. This study utilized atomic force microscopy (AFM) to measure the viscoelastic properties of ovarian cancer cells and then examined the association with the invasion of ovarian cancer at the level of living single cells. Elasticity and viscosity of the ovarian cancer cells OVCAR-3 and HO-8910 are significantly lower than those of the human ovarian surface epithelial cell (HOSEpiC) control. Further examination found a dramatic increase of migration/invasion and an obvious decease of microfilament density in OVCAR-3 and HO-8910 cells. Also, there was a significant relationship between viscoelastic and biological properties among these cells. In addition, the elasticity was significantly increased in OVCAR-3 and HO-8910 cells after the treatment with the anticancer compound echinomycin (Ech), while no obvious change was found in HOSEpiC cells after Ech treatment. Interestingly, Ech seemed to have no effect on the viscosity of the cells. Ech significantly inhibited the migration/invasion and significantly increased the microfilament density in OVCAR-3 and HO-8910 cells, which was significantly related with the elasticity of the cells. An increase of elasticity and a decrease of invasion were found in OVCAR-3 and HO-8910 cells after Ech treatment. Together, this study clearly demonstrated the association of viscoelastic properties with the invasion of ovarian cancer cells and shed a light on the biomechanical changes for early diagnosis of tumor transformation and progression at single-cell level.
Revealing the local crystallinity of single silicon core-shell nanowires using tip-enhanced Raman spectroscopy
Authors: van den Berg Marius , Moeinian Ardeshir , Kobald Arne , Chen Yu-Ting , Horneber Anke , Strehle Steffen , Meixner Alfred J , Zhang Dai
Published: April 2020

Tip-enhanced Raman spectroscopy is combined with polarization angle-resolved spectroscopy to investigate the nanometre-scale structural properties of core-shell silicon nanowires (crystalline Si core and amorphous Si shell), which were synthesized by platinum-catalyzed vapor-liquid-solid growth and silicon overcoating by thermal chemical vapour deposition. Local changes in the fraction of crystallinity are characterized for those silicon nanowires at an optical resolution of about 300 nm. Furthermore, we are able to resolve the variations in the intensity ratios between the crystalline Si and the amorphous Si Raman peaks by applying tip-enhanced Raman spectroscopy, at sample positions being eight nanometers apart. The local crystallinity revealed using confocal Raman spectroscopy and tip-enhanced Raman spectroscopy agree well with the high-resolution transmission electron microscopy measurements. Additionally, the polarizations of Raman scattering and the photoluminescence signal from the tip-sample nanogap are explored by combining polarization angle-resolved emission spectroscopy with tip-enhanced optical spectroscopy. Our work demonstrates the significant potential of resolving local structural properties of Si nanomaterials at the sub-10 nanometer scale using tip-enhanced Raman techniques.
Performance Analysis of a Heat Pipe with Stainless Steel Wick
Authors: Haque Md Enamul , Hossain Md Efthakher , Mashud Mohammad
Published: April 2020

In this study, the influences of different parameters on performance of a heat pipe with stainless steel net as wick have been presented. Experiments have been carried out for an input power range from 80 W to 160 W, constant cooling water mass flow rate of 0.0515 liter/s, and constant temperature at the inlet to condenser of 11°C. The temperatures were recorded at different power level by using a laser thermometer of the heater block, evaporator and condenser end at 50 second interval. Variation in the input power was done by varying the input voltage. It was done by a variack. Considering all criteria the copper is selected as the material of the container, water is selected as the working fluid of the heat pipe, stainless steel net is used as wick material. As copper/water heat pipes are able to tolerate storage temperatures between -65°C and 250°C, and can effectively operate between 10°C and 250°C. So a .9144 m copper tube is used to construct the heat pipe. Inside this tube stainless steel net is used as wick material to aid the flow of fluid. In the observation it is observed that the temperature of the evaporator end increases at a greater rate of the copper pipe than the heat pipe at different power level. It has been shown the variation of temperature of the heater block and the evaporator section at 80V, 100V, 120V, 140V, 160V respectively of the heat pipe and copper pipe.
Design and Implementation of LOD Explorer: A LOD Exploration and Visualization Model
Authors: Jacksi Karwan , Zeebaree Subhi , Dimililer Nazife
Published: April 2020

The quantity of data published on the Web according to principles of Linked Data (LD) is increasing intensely. However, this data is still largely limited to be used up by domain professionals and users who understand LD technologies. Therefore, it is essential to develop tools to enhance intuitive perceptions of LD for lay users. The features of LD point to various challenges for an easy-to-use data presentation. In this research, the technical details behind the LOD Explorer, which is a tool for exploring the Web of Data, is presented, the efficiency and scalability of the system has been tested using several different platforms, and the results of experiments indicated an outstanding performance.
DESCENT TRAJECTORY MODELLING FOR THE LANDING SYSTEM PROTOTYPE
Authors: Glaser-Opitz Henrich , Labun Ján , Budajová Kristína , Glaser-Opitz Leonard
Published: April 2020

This paper gives another view on a method used for aircraft approach and landing phase of flight
that enables replacement of standard glideslope. Proposed Landing System is based on Terrain Reference Navigation (TRN)
using own created terrain elevation database, based on Radar Altimeter (RA) measurements compared to the overflown terrain.
Simulations were performed on a chosen airport (KSC – Košice Airport) and aircraft (Boeing 737-800), where descend procedures
was designed based on real airline data in compliance with Initial 4D Trajectory (i4D). Descend trajectory was modelled with
EUROCONTROL Base of Aircraft DAta (BADA) performance model as a Continuous Descent Approach (CDA) from proposed merging point
to the KSC RunWaY (RWY) threshold. This method was proposed to enhance pilot situational awareness in situations when standard
Instrument Landing System (ILS) information could be lost or misleading and without the need of any ground station for successful
navigation and guidance to the RWY threshold. Landing System prototype flight test were performed on full mission flight simulator.
A 1201 s Orbital Period Detached Binary: The First Double Helium Core White Dwarf LISA Verification Binary
Authors: Brown Warren R. , Kilic Mukremin , Bédard A. , Kosakowski Alekzander , Bergeron P.
Published: April 2020

We report the discovery of a 1201 s orbital period binary, the third shortest-period detached binary known. Sloan Digital Sky Survey J232230.20 + 050942.06 contains two He-core white dwarfs orbiting with a 27° inclination. Located 0.76 kpc from the Sun, the binary has an estimated Laser Interferometer Space Antenna (LISA) 4 yr signal-to-noise ratio of 40. J2322 + 0509 is the first He + He white dwarf LISA verification binary, a source class that is predicted to account for one-third of resolved LISA ultra-compact binary detections.
The wild bees (Hymenoptera, Apoidea) of the island of Cyprus
Authors: Varnava Androulla I. , Roberts Stuart P. M. , Michez Denis , Ascher John S. , Petanidou Theodora , Dimitriou Stavroula , Devalez Jelle , Pittara Marilena , Stavrinides Menelaos C.
Published: April 2020

Cyprus, the third largest island in the Mediterranean, constitutes a biodiversity hotspot with high rates of plant endemism. The wild bees of the island were studied extensively by the native George Mavromoustakis, a world-renowned bee taxonomist, who collected extensively on the island from 1916 to 1957 and summarised his results in a series of eight Cyprus-specific papers published from 1949 [“1948”] to 1957. The current work represents the first modern checklist of the wild bees of Cyprus, based on a compilation of previous publications, museum specimens and authors’ recent collections. Overall, 369 verified wild bee species have been recorded on the island, with eleven species reported from Cyprus for the first time. The island hosts all six of the globally widespread bee families, with Apidae represented by 110 species, Megachilidae with 91, Andrenidae with 76, Halictidae with 72, Colletidae with 19, and Melittidae with 1. Twenty-one of the recorded bee species are endemic (i.e., 5.7 % endemism rate) and Cyprus ranks third after Lesvos and Sicily in known bee species richness among the Mediterranean islands. Previously unpublished records from various locations on Cyprus for 156 previously reported bee species are also provided in the study. The current work provides a baseline for future studies of wild bee diversity on the island of Cyprus and neighbouring regions.
Management of Suicidality with Borderline and Narcissistic Features
Authors: Unruh Brandon T.
Published: April 2020

General suicide risk assessment and management should include consideration of core borderline and narcissistic vulnerabilities of interpersonal hypersensitivity and self-esteem dysregulation. Understanding the oscillating phenomenology of these vulnerabilities using the basic personality disorder treatment approach of Good Psychiatric Management provides a coherent, practical method for assessing and managing suicide risk not only in patients with these personality disorders but more broadly in those with some traits of personality disorder but not meeting full diagnostic criteria.[Psychiatr Ann. 2020;50(4):139–145.]
A Study of the Influence of Social Media Use on Employees' Psychological Distress and the Moderating Effect of Perceived Organizational Support
Authors: Choi Youngkeun
Published: April 2020

The purpose of this study is to propose an integral model for the influence of the mental properties of professional literacy in social media on employees' psychological distress and investigate a managerial factor moderating the influence of mental properties of professional literacy in social media on employees' psychological distress. For this, using survey method, this study distributed the survey to 305 employees working at Korean companies. This study used a series of multiple regression analyses. In the results, first, invasion and uncertainty among the mental properties of professional literacy in social media increases employees' psychological distress. However, overload has no significance with employees' psychological distress. Second, perceived organizational support has a moderating effect on the relationship between uncertainty and psychological distress. However, perceived organizational support has no effect on the relation between invasion and psychological distress.
Pricing and Bundling Strategies for Competing Mobile Phone Supply Chains With Network Externality
Authors: Yue Yunpeng , Xiao Tiaojun
Published: April 2020

In mobile phone supply chains, consumers can choose handsets and telecommunication services as a bundled package or buy handsets and services independently. This article develops a multi-agent simulation model to explore price, subsidy and bundling decisions for competing mobile phone supply chains with network externality, where each chain includes one mobile phone manufacturer and one service operator. There are two bundling strategies: free or bundled. The results indicate that: 1) if the impact of network externality is not too small, then competitive differentiation can be formed when one party adopts a bundled one. If bundled scenario is adopted by both, the total profit is reduced. Consequently, both service operators and manufacturers choose (accept) different bundling strategies; 2) network externality and consumer heterogeneity both increase the advantage of bundled scenario in the asymmetric setting; 3) when the effect of network externality is sufficiently small, free scenario is dominant; and 4) consumer heterogeneity can alleviate competition in the symmetric settings.
A Model Based on Data Envelopment Analysis for the Measurement of Productivity in the Software Factory
Authors: Castañeda Pedro , Mauricio David
Published: April 2020

Productivity in software factories is very important because it allows organizations to achieve greater efficiency and effectiveness in their activities. One of the pillars of competitiveness is productivity, and it is related to the effort required to accomplish the assigned tasks. However, there is no standard way to measure it, making it difficult to establish policies and strategies to improve the factory. In this work, a model based on data envelopment analysis is presented to evaluate the relative efficiency of the software factories and their projects, to measure the productivity in the software production component of the software factory through the activities that are carried out in their different work units. The proposed model consists of two phases in which the productivity of the software factory is evaluated and the productivity of the projects it conducts is assessed. Numerical tests on 6 software factories with 160 projects implemented show that the proposed model allows one to assess the software factories and the most efficient projects.
Serotonin (5-HT) Shapes the Macrophage Gene Profile through the 5-HT2B–Dependent Activation of the Aryl Hydrocarbon Receptor
Authors: Nieto Concha , Rayo Ignacio , de las Casas-Engel Mateo , Izquierdo Elena , Alonso Bárbara , Béchade Catherine , Maroteaux Luc , Vega Miguel A. , Corbí Ángel L.
Published: April 2020

Macrophages can either promote or resolve inflammatory responses, and their polarization state is modulated by peripheral serotonin (5-hydroxytryptamine [5-HT]). In fact, pro- and anti-inflammatory macrophages differ in the expression of serotonin receptors, with 5-HT2B and 5-HT7 expression restricted to M-CSF–primed monocyte-derived macrophages (M-MØ). 5-HT7 drives the acquisition of profibrotic and anti-inflammatory functions in M-MØ, whereas 5-HT2B prevents the degeneration of spinal cord mononuclear phagocytes and modulates motility of murine microglial processes. Because 5-HT2B mediates clinically relevant 5-HT–related pathologies (valvular heart disease, pulmonary arterial hypertension) and is an off target of anesthetics, antiparkinsonian drugs, and selective serotonin reuptake inhibitors, we sought to determine the transcriptional consequences of 5-HT2B engagement in human macrophages, for which 5-HT2B signaling remains unknown. Assessment of the effects of specific agonists and antagonist revealed that 5-HT2B engagement modifies the cytokine and gene signature of anti-inflammatory M-MØ, upregulates the expression of aryl hydrocarbon receptor (AhR) target genes, and stimulates the transcriptional activation of AhR. Moreover, we found that 5-HT dose dependently upregulates the expression of AhR target genes in M-MØ and that the 5-HT–mediated activation of AhR is 5-HT2B dependent because it is abrogated by the 5-HT2B–specific antagonist SB204741. Altogether, our results demonstrate the existence of a functional 5-HT/5-HT2B/AhR axis in human macrophages and indicate that 5-HT potentiates the activity of a transcription factor (AhR) that regulates immune responses and the biological responses to xenobiotics.
Prognostic Value of TP53 Mutation for Transcatheter Arterial Chemoembolization Failure/Refractoriness in HBV-Related Advanced Hepatocellular Carcinoma
Authors: Xue Miao , Wu Yanqin , Fan Wenzhe , Guo Jian , Wei Jialiang , Wang Hongyu , Tan Jizhou , Wang Yu , Yao Wang , Zhao Yue , Li Jiaping
Published: April 2020

PurposeThis study aimed to investigate the clinicopathologic features and mutational landscape of patients with hepatitis B virus (HBV)–related advanced hepatocellular carcinomas (HCC) undergoing transcatheter arterial chemoembolization (TACE).Materials and MethodsFrom January 2017 to December 2018, 38 patients newly diagnosed with HBV-related advanced HCC were enrolled in the final analysis. Their pathological tissues and corresponding blood samples before TACE treatment were collected for whole-exome sequencing. Response to TACE was evaluated at 1-3 months after two consecutive use of TACE. Predictive factors were analyzed by univariate and multivariate analyses in a bivariate Logistic regression model. Enrichment of related pathways of all driver genes were acquired using the gene set enrichment analysis (GSEA).ResultsAmong 38 patients, 23 (60.5%) exhibited TACE failure/refractoriness. Patients with TACE failure/refractoriness showed higher frequency of TP53 mutation than their counterparts (p=0.020). Univariate and multivariate analyses showed that only vascular invasion and TP53 mutation were significantly correlated with TACE failure/refractoriness in HBV-related advanced HCC. Of the 16 patients without vascular invasion, eight (50.0%) had TP53 mutations, and TP53 mutation was associated with TACE failure/refractoriness (p=0.041). Moreover, GSEA showed that mitogen-activated protein kinase and apoptosis pathways induced by TP53 mutation were possibly associated with TACE failure/refractoriness.ConclusionOur study suggested that TP53 mutation was independently related with TACE efficacy, which may work via mitogen-activated protein kinase and apoptosis pathways. These findings may provide evidence to help distinguish patients who will particularly benefit from TACE from those who require more personalized therapeutic regimens and rigorous surveillance in HBV-related advanced HCC.
Digitalisation Advances and Hospitality Service Encounters
Authors: Montargot Nathalie
Published: April 2020

A new hospitality concept gives more autonomy to the clients and mobility to the front-line employees. The objective of this research was to observe in situ the actors, customers and receptionists, operating in renewed lobbies. The research questions focus on how customers respond to the increased expectations of self-production and the way front-line employees adapt to their new roles. The review of literature highlights the importance of the service production process, its stages and customer integration in the innovative process. A study was conducted in a 4-star pilot Parisian hotel affiliated to a major French hotel group. 490 non-participant observations, based on encounters of service were collected. The findings show the gap between the project's philosophy and the behavior of the actors on the ground. Managerial recommendations are presented.
Estudo envolvendo a função das imagens associadas a tópicos de Física Moderna nos livros didáticos do ensino médio
Authors: Rosa Cleci Teresinha Werner da , Biazus Marivane De Oliveira , Darroz Luiz Marcelo
Published: April 2020

O estudo refere-se a uma investigação a respeito das imagens presentes nos livros didáticos de Física do ensino médio aprovados pelo Programa Nacional do Livro Didático (PNLD) 2018. O objetivo foi avaliar como essas imagens estão sendo utilizadas pelos autores para ilustrar os tópicos de Física Moderna referentes à radiação do corpo negro, ao efeito fotoelétrico, aos modelos atômicos e à espectroscopia. Como suporte teórico, adotou-se a taxonomia proposta por Perales e Jiménez (2002) para analisar a relação e a função das imagens junto ao texto. Os resultados desse estudo indicam que as obras apresentam uma grande diversidade na maneira como as imagens são apresentadas e que é necessário haver cuidado com as relações estabelecidas entre a imagem e o texto nesse recurso didático, visto que desempenham importante papel no processo de ensino e aprendizagem.
Artefatos digitais para o Museu DICA: contribuições para a formação de professores de Física
Authors: Barros Matheus , Martins Silvia
Published: April 2020

No contexto das licenciaturas, pouco se ouve falar sobre espaços diferentes da escola para a realização de atividades didáticas. No entanto, pesquisas sobre práticas em espaços não formais, em especial os museus de ciência, vem aumentando cada vez mais. Nesse sentido, é importante que, além do incentivo às práticas em espaços fora da escola, também haja um despertar de interesse e treinamento para a efetivação de tais atividades. Desse modo, este trabalho apresenta uma pesquisa realizada com estudantes da disciplina de PROJETOS INTEGRADOS DE PRÁTICAS EDUCATIVAS 3 (PIPE 3), do curso de Física Licenciatura, da Universidade Federal de Uberlândia (UFU), no primeiro semestre de 2016, a fim de evidenciar as possíveis contribuições para a formação de professores de Física diante da construção de artefatos digitais para a exposição de Eletromagnetismo do Museu Diversão com Ciência e Arte – DICA. Nessa pesquisa, ficaram evidentes a evolução das concepções dos estudantes de PIPE 3 quanto aos museus de ciências, e o reconhecimento destes como espaços educativos e diferentes da escola; bem como os saberes despertados e agregados durante essa etapa da formação profissional. Desse modo, acreditamos que esse trabalho evidenciou as vantagens em se trabalhar em espaços diferentes da escola na formação inicial de professores.
Análise comparativa dos modelos usados como ferramenta metodológica nas pesquisas sobre o Conhecimento Pedagógico de Conteúdo (PCK) de professores de Física no Brasil
Authors: Lima Stela Silva , Darsie Marta Maria Pontin , Mello Geison Jader
Published: April 2020

A base de conhecimento de professores vem sendo objeto de pesquisas, em diversas áreas da educação, ao longo de muitas décadas, sendo abordada por diferentes perspectivas teóricas e autores, dentre os quais o conceito introduzido por Lee Shulman (1986; 1987), Conhecimento Pedagógico de Conteúdo (PCK), é o foco deste artigo. Mesmo com a longevidade do tema PCK, as bases teóricas e metodológicas usadas nestas investigações são dispersas, não há consenso quanto a conceitos, terminologia, abrangência e componentes dos modelos adotados para estudo do conhecimento de professores. Com o objetivo de identificar as diferentes visões sobre o conhecimento de professores de Física, presentes nos modelos apoiados na base teórica do PCK e adotados na condução de pesquisas em Ensino de Física, foi conduzida uma revisão sistemática da literatura para identificação dos modelos nelas adotados. Após a identificação destes, fez-se um estudo aprofundado das referências originais de cada modelo, para então proceder-se a análise comparativa com intuito de identificar suas similaridades, divergências e lacunas. Esta análise aponta que, em sua maioria, os modelos adotados para estudo do conhecimento de professores de Física, contemplam, para caracterização da base de conhecimento de professores, os mesmos Componentes. Porém, há divergências conceituais sobre a formação e desenvolvimento destes conhecimentos, assim como diferem as delimitações da abrangência de cada modelo. Percebe-se também, pela evolução temporal dos modelos adotados, que há uma tendência à especialização na modelagem dos conhecimentos de professores de Física.
Corpos secos ou molhados? Representações do suor em duas academias de ginástica do Rio de Janeiro, Brasil
Authors: Silva Alan Camargo , Ferreira Jaqueline
Published: April 2020

Embora "suar a camisa" seja uma expressão ética comum no âmbito das práticas corporativas, porque esse discurso foi simbolicamente explorado na área de Educação Física. Assim, ou o objetivo deste trabalho, foi capaz de entender em que medida os representantes de dois praticantes de construção muscular nas academias de ginástica estavam preocupados com sua influência sobre nós e seus seis anos. Com base na abordagem antropológica, durante um ano, foi realizada uma etnografia comparativa em duas academias inseridas em contextos socioeconômicos e culturais diferentes do Rio de Janeiro. Concluo que uma multiplicidade de significados atribuídos ou perdidos por algumas influências ou encantamentos dois meses depois não pode ser exercida.
“Everything is scorched by the burning sun”: missionary perspectives and experiences of 19th- and early 20th-century droughts in semi-arid central Namibia
Authors: Grab Stefan , Zumthurm Tizian
Published: April 2020

Abstract. Limited research has focussed on historical droughts during the
pre-instrumental weather-recording period in semi-arid to arid
human-inhabited environments. Here we describe the unique nature of droughts
over semi-arid central Namibia (southern Africa) between 1850 and 1920. More
particularly, our intention is to establish temporal shifts in influence and
impact that historical droughts had on society and the environment during
this period. This is achieved through scrutinizing documentary records
sourced from a variety of archives and libraries. The primary source of
information comes from missionary diaries, letters, and reports. These
missionaries were based at a variety of stations across the central Namibian
region and thus collectively provide insight into subregional (or site-specific) differences in hydrometeorological conditions and
drought impacts
and responses. The earliest instrumental rainfall records (1891–1913) from
several missionary stations or settlements are used to quantify
hydrometeorological conditions and compare them with documentary sources. The
work demonstrates strong subregional contrasts in drought conditions during
some given drought events and the dire implications of failed rain seasons,
the consequences of which lasted for many months to several years. The paper
argues that human experience and associated reporting of drought events
depends strongly on social, environmental, spatial, and societal
developmental situations and perspectives. To this end, the reported
experiences, impacts, and responses to drought over this 70-year period
portray both common and changeable attributes through time.
Evaluating the suitability of the consumer low-cost Parrot Flower Power soil moisture sensor for scientific environmental applications
Authors: Xaver Angelika , Zappa Luca , Rab Gerhard , Pfeil Isabella , Vreugdenhil Mariette , Hemment Drew , Dorigo Wouter Arnoud
Published: April 2020

Abstract. Citizen science, scientific work and data collection conducted by or with non-experts, is rapidly growing. Although the potential of citizen science activities to generate enormous amounts of data otherwise not feasible is widely recognized, the obtained data are often treated with caution and scepticism. Their quality and reliability is not fully trusted since they are obtained by non-experts using low-cost instruments or scientifically non-verified methods.
In this study, we evaluate the performance of Parrot's Flower Power soil moisture sensor used within the European citizen science project the GROW Observatory (GROW; https://growobservatory.org, last access: 30 March 2020). The aim of GROW is to enable scientists to validate satellite-based soil moisture products at an unprecedented high spatial resolution through crowdsourced data. To this end, it has mobilized thousands of citizens across Europe in science and climate actions, including hundreds who have been empowered to monitor soil moisture and other environmental variables within 24 high-density clusters around Europe covering different climate and soil conditions. Clearly, to serve as reference dataset, the quality of ground observations is crucial, especially if obtained from low-cost sensors.
To investigate the accuracy of such measurements, the Flower Power sensors were evaluated in the lab and field. For the field trials, they were installed alongside professional soil moisture probes in the Hydrological Open Air Laboratory (HOAL) in Petzenkirchen, Austria. We assessed the skill of the low-cost sensors against the professional probes using various methods. Apart from common statistical metrics like correlation, bias, and root-mean-square difference, we investigated and compared the temporal stability, soil moisture memory, and the flagging statistics based on the International Soil Moisture Network (ISMN) quality indicators. We found a low intersensor variation in the lab and a high temporal agreement with the professional sensors in the field. The results of soil moisture memory and the ISMN quality flags analysis are in a comparable range for the low-cost and professional probes; only the temporal stability analysis shows a contrasting outcome.
We demonstrate that low-cost sensors can be used to generate a dataset valuable for environmental monitoring and satellite validation and thus provide the basis for citizen-based soil moisture science.
Verification of the regional atmospheric model CCLM v5.0 with conventional data and lidar measurements in Antarctica
Authors: Zentek Rolf , Heinemann Günther
Published: April 2020

Abstract. The nonhydrostatic regional climate model CCLM was used for
a long-term hindcast run (2002–2016) for the Weddell Sea region with
resolutions of 15 and 5 km and two different turbulence
parametrizations. CCLM was nested in ERA-Interim data and used in
forecast mode (suite of consecutive 30 h long simulations with
6 h spin-up). We prescribed the sea ice concentration from
satellite data and used a thermodynamic sea ice model. The
performance of the model was evaluated in terms of temperature and
wind using data from Antarctic stations, automatic weather stations (AWSs), an
operational forecast model and reanalyses data, and lidar wind
profiles. For the reference run we found a warm bias for the
near-surface temperature over the Antarctic Plateau. This bias was
removed in the second run by adjusting the turbulence parametrization,
which results in a more realistic representation of the surface
inversion over the plateau but resulted in a negative bias for some
coastal regions. A comparison with measurements over the sea ice of
the Weddell Sea by three AWS buoys for 1 year showed small biases
for temperature around ±1 K and for wind speed of
1 m s−1. Comparisons of radio soundings showed a model bias
around 0 and a RMSE of 1–2 K for temperature and
3–4 m s−1 for wind speed. The comparison of CCLM
simulations at resolutions down to 1 km with wind data from
Doppler lidar measurements during December 2015 and January 2016
yielded almost no bias in wind speed and a RMSE of ca. 2 m s−1. Overall CCLM shows a good representation of temperature and
wind for the Weddell Sea region. Based on these encouraging results,
CCLM at high resolution will be used for the investigation of the
regional climate in the Antarctic and atmosphere–ice–ocean
interactions processes in a forthcoming study.