bluuebunny/crossref_metadata_2025 huggingface dataset:
Vena cava superioron keresztül végzett pulmonálisvéna-izoláció elzárt vena cava inferior esetén
Authors: Párkányi Boglár , Tahin Tamás , Riba Ádám
Published: May 2024

A pulmonálisvéna-izoláció elsőként válaszható terápiás lehetőség pitvarfibrillációban, különösen szívelégtelenséggel járó vagy gyógyszeres terápiára rezisztens esetekben. A beavatkozás több technikával is végezhető, de a kezdeti lépések között mindig szerepel a combvéna perkután punkciója, majd a katéterek jobb pitvarba juttatása. Ritkán ez nem kivitelezhető a szokásostól eltérő érfejlődési variáció, például elzárt vena cava inferior miatt, ilyenkor alternatív behatolási kapu használata jön szóba. Esetünkben egy elzárt vena cava inferiorral élő, 48 éves, perzisztens pitvarfibrilláló nőbeteg vena jugularis punkciót követő, vena cava superior felől végzett sikeres ablációjának menetét és körülményeit mutatjuk be.
A pitvarfibrilláció és az agy
Authors: Zádori Dénes , Klivényi Péter
Published: May 2024

Az agyi érkatasztrófa, azaz a stroke amellett, hogy a második leggyakoribb halálok, az egyik leggyakoribb rokkantságot okozó kórállapot. Az esetek közel harmadában kóroki tényezőként kardiális embolizáció, a leggyakrabban pitvarfibrilláció merül fel. A pitvarfibrilláció detektálásának terápiás szempontból is kiemelt jelentősége van, hiszen ilyenkor másodlagos stroke-prevenció céljából az antikoaguláns-kezelés az elsőként választandó, preferáltan direkt orális antikoagulánssal végezve. A stroke mellett vagy azon felül a pitvarfibrilláció az előidézett agyi funkciókárosodás révén kognitív hanyatláshoz is vezethet, amely szintén jelentősen ronthatja a betegek életminőségét. Itt kóroki tényezőként leginkább cerebrális tromboembólia (beleértve a csendes agyi infarktusokat is), hipoperfúzió, illetve mikrovérzések merülnek fel, de gyulladásos folyamatok és genetikai faktorok is szerepet játszhatnak. A kardiovaszkuláris rizikófaktorok csökkentése, az antikoaguláns-kezelés és a megfelelő ritmus- és/vagy frekvenciakontroll révén a kognitív tünetek megjelenése is jelentősen mérsékelhető.
The Year in Hungarian Cardiology 2023: Arrhythmias
Authors: Kosztin Annamária , Szegedi Nándor , Salló Zoltán , Schwertner Walter Richard , Gellér László
Published: May 2024

In 2023, Hungary produced notable scientific publications focused on cardiac arrhythmias. This review highlights the most impactful papers, authored at least in part by Hungarians, featuring work conducted at Hungarian research sites and published in international peer-reviewed journals. We give a short overview regarding papers dealing with the role of imaging (different types of ultrasound, cardiac magnetic resonance imaging and electroanatomical mapping) in treating cardiac arrhythmias. We summarize the novelties of ischemic complications of atrial fibrillation (AF), cerebral safety of AF ablation, and current AF ablation techniques. Optimizing risk stratification of ventricular tachycardia (VT) ablation was a landmark paper of our “machine learning” research. Further studies have made significant strides in cardiac device therapy, notably through the groundbreaking BUDAPEST-CRT Upgrade Trial for heart failure, which demonstrated marked reductions in deaths and hospitalizations following Cardiac Resynchronization Therapy (CRT) upgrade procedures. Research on the impact of frailty on CRT outcomes has underscored the importance of tailored treatments. Artificial intelligence, particularly topological data analysis, has been crucial in personalizing CRT therapy. Additionally, advancements in remote monitoring and lead extraction techniques have mirrored the rapid evolution of cardiac technology and care.
Advancing Force Fields Parameterization: A Directed Graph Attention Networks Approach
Authors: Chen Gong , Jaffrelot Inizan Théo , Plé Thomas , Lagardère Louis , Piquemal Jean-Philip , Maday Yvon
Published: May 2024

Force Fields (FFs) are an established tool for simulating large and complex molecular systems. However, parametrizing FFs is a challenging and time-consuming task that relies on empirical heuristics, experimental data, and computational data. Recent efforts aim to automate the assignment of FF parameters using pre-existing databases and on-the-fly ab-initio data. In this study, we propose a Graph-Based Force Fields (GB-FFs) model to directly derive parameters for the Generalized Amber Force Field (GAFF) from chemical environments and research into the influence of functional forms. Our end-to-end parameterization approach eliminates the need for expert-defined procedures and enhances the accuracy and transferability of GAFF across a broader range of molecular complexes. The GB-FFs model, which is only grounded on ab initio data, is implemented in the highly parallel Tinker-HP GPU package. Simulation results are compared to the original GAFF parameterization and validated on various experimentally and computationally derived properties, including free energies.
Nanobody Engineering: Computational Modelling and Design for Biomedical and Therapeutic Applications
Authors: El Salamouni Nehad , Cater Jordan , Spenkelink Lisanne , Yu Haibo
Published: May 2024

Nanobodies, the smallest functional antibody fragment derived from camelid heavy-chain-only antibodies, have emerged as powerful tools for diverse biomedical applications. In this comprehensive review, we discuss the structural characteristics, functional properties, and computational approaches driving the design and optimisation of synthetic nanobodies. We explore their unique antigen-binding domains, highlighting the critical role of complementarity-determining regions in target recognition and specificity. This review further underscores the advantages of nanobodies over conventional antibodies from a biosynthesis perspective, including their small size, stability, and solubility, which make them ideal candidates for economical antigen capture in diagnostics, therapeutics, and biosensing. We discuss the recent advancements in computational methods for nanobody modelling, epitope prediction, and affinity maturation, shedding light on their intricate antigen-binding mechanisms and conformational dynamics. Finally, we examine a direct example of how computational design strategies were implemented for improving a nanobody-based immunosensor, known as a Quenchbody. Through combining experimental findings and computational insights, this review elucidates the transformative impact of nanobodies in biotechnology and biomedical research, offering a roadmap for future advancements and applications in healthcare and diagnostics.
Dynamic cycling enhances battery lifetime
Authors: Geslin Alexis , Xu Le , Ganapathi Devi , Moy Kevin , Chueh William , Onori Simona
Published: May 2024

Laboratory aging campaigns benchmark and elucidate the complex degradation behavior of lithium-ion batteries, and are critical not only for developing new battery chemistries and cell designs but also for engineering reliable battery management systems. Critically, these laboratory experiments aim to quantify and capture realistic aging mechanisms. In this study, we systematically compare dynamic discharge profiles representative of electric vehicle driving to the well-accepted constant-current profiles. Surprisingly, we discovered that dynamic discharge enhances lifetime substantially compared to constant current discharge. Specifically, for the same average current and voltage window, varying the dynamic discharge profile leads to an increase of up to 38 % in equivalent full cycles at end-of-life. Explainable machine learning reveals the importance of low-frequency current pulses as well as time-induced aging under these realistic discharge conditions. Our work quantifies the importance of evaluating new battery chemistries and designs with realistic load profiles, and highlights the opportunities to revisit our understanding of aging mechanisms at the chemistry, materials, and cell levels.
Formulating reduced density gradient approaches for noncovalent interactions
Authors: Guerra Cristian , Burgos José , Ayarde-Henríquez Leandro , Chamorro Eduardo
Published: May 2024

This work elucidates several forms of reduced electron density gradient (RDG) to describe non-covalent interactions (NCIs). By interpreting the RDG as a local-moment function, we systematically leveraged Weizacker's and Fermi's local moments. This resulted in high-fidelity RDG representations consistent with the NCI analysis. In addition, the RDG version derived from the Lagrangian kinetic energy density is conveniently normalized. These results suggest the non-existence of a particular RDG formulation when performing NCI analysis. Thus, an in-depth examination of the theoretical foundations connecting the RDG function with the nature of non-covalent interactions is necessary.
What impact does tautomerism have on drug properties and development?
Authors: Dhaked Devendra , Nicklaus Marc
Published: May 2024

This mini-review reports on effects that tautomerism has on predicted and clinically observed small-molecule properties important for drug design and drug behaviour in the patient. We present examples of both pharmacokinetics and pharmacodynamics effects. The importance of tautomerism on drugs’ formulation and possible interconversion of stereoisomers is also discussed.
La última canción: al encuentro de memorias del seeptsá entre Cachicoto y Juanjuí
Authors: Rojas-Berscia Luis Miguel , Pérez Valderrama Martha , Tangoa Pérez Susy Caroly , García García Luis Gonzalo
Published: May 2024

El cholón o seeptsá es una lengua indígena peruana considerada extinta o durmiente. En el presente artículo, mostramos evidencias de la existencia de recordadores de esta lengua en la actualidad, en la forma de datos recolectados en el campo en la ciudad de Juanjuí con el apoyo de Martha Pérez Valderrama, recordadora de la lengua cholona y nieta de una de las últimas hablantes activas de la lengua, Victoria Cerquera Ojeda. Describimos los detalles del viaje realizado entre los departamentos de Huánuco y San Martín, así como detalles de los hallazgos de tipo sociolingüístico y documental. Finalmente, proveemos un primer análisis de una canción y un breve cuento en lengua cholona de Martha Pérez Valderrama.
As lições do mel e as transformações entre modos de vida
Authors: Otto Diniz Renata , Cangussu Daniel
Published: May 2024

Partindo das conotações e agências atribuídas ao mel, nas Mitológicas de Lévi-Strauss, tentamos conectar alguns pontos que propiciam a transformação na imagem conceito, amplamente consolidado na etnologia, de “regressão agrícola”. Sugerimos a contra imagem da “perda vantajosa” para ressignificar aquele movimento entre os modos de subsistência historicamente adotados pelas sociedades ameríndias, do mais agricultor ao mais forrageador. Chamamos atenção, em primeiro lugar, para a natureza não categórica da diferença entre tais modos e, em segundo lugar, mobilizamos argumentos que reivindicam a perspectiva nativa da história, para deslocar qualquer tipo de determinismo sobre a cultura ou a sociedade indígena. Seguimos Lévi-Strauss, quando ele afirma que o mel proporciona ocasião para especular sobre uma notável reviravolta: ele é o motivo de uma rotação de perspectiva segundo a qual os humanos passam a advogar em favor de uma economia de coleta, atribuindo-lhe as virtudes de variedade, abundância e longa preservação, que a perspectiva inversa atribuía à adoção da agricultura. Sugerimos que o mel faz papel de avatar da coleta ou do modo de vida forrageiro, corporificando os valores nativos. Tendo isso em mente, comparamos situações entre coletivos tupi-guarani, alguns deles descritos como “objetos” daquela “regressão agrícola”, para melhor compreender a rotação e testamos alguma generalidade.
"A Noção de Objeto", de Alain (Émile Chartier)
Authors: Lacour Philippe , Matos Lima Melo Felipe , Oliveira Chaia Jade , Mendes Sbervelheri Mariana , Alves Teixeira Michelly , Santos dos Prazeres Rogério
Published: May 2024

O texto aqui traduzido foi publicado originalmente na Revue de Métaphysique et de Morale, em janeiro de 1901. Trata-se de um dos artigos publicados por Alain, pseudônimo utilizado por Émile Chartier. A tradução foi realizada pelo Grupo de Tradução do Departamento de Filosofia da Universidade de Brasília, coordenado pelo Professor Philippe Lacour. O grupo se propõe a traduzir regularmente obras de filosofia ainda inéditas em língua portuguesa e disponibilizá-las em periódicos de acesso livre. O trabalho de tradução é produzido de maneira colaborativa através da plataforma digital TraduXio (https://traduxio.org/).
On Ur-intentionality
Authors: Soutif Ludovic , Márquez Carlos
Published: May 2024

Starting from Brentano’s classical characterization of intentionality, we review the radical enactivist proposal about basic cognition and show that the underlying assumption that stripping teleosemantics of its representationalist commitments results in no explanatory loss is unwarranted. Significant features of basic cognition are lost, or so we argue, with the RECtification of teleosemantics that are retrieved by means of an alternative dubbed metaphysically non-committal content-ascriptivism.
Diversidades em um livro didático de língua inglesa: representações visuais e/em interseccionalidade
Authors: Milani Victor Gomes
Published: May 2024

À luz de uma perspectiva da Linguística Aplicada (LA) do século XXI (MOITA LOPES, 2006), o presente artigo propõe uma análise inicial de representações de pessoas veiculadas pela linguagem visual sob uma perspectiva sociossemiótica (KRESS; VAN LEEUWEN, 2006; NASCIMENTO; BEZERRA; HEBERLE, 2011) e interseccional (CRENSHAW, 2002; LIBARDI; JACKS, 2020) em um livro didático de língua inglesa. O corpus deste estudo é composto por 27 recursos imagéticos, os quais estão distribuídos em 12 páginas de abertura de unidade do Livro Didático (LD). O LD selecionado pertence ao componente curricular Língua Estrangeira Moderna (Inglês) chama-se Way to English for Brazilian Learners (editora Ática, 2020, 3ª edição) e é direcionado ao sexto ano do Ensino Fundamental. Foram adotados os seguintes passos analíticos: a) identificação do número de recursos imagéticos com pessoas presentes nas páginas de abertura das unidades; b) contagem, tabulação e descrição dos recursos imagéticos com foco na representação de pessoas através dos significados representativos da Gramática do Design Visual (GDV) (KRESS; VAN LEEUWEN, 2006; NASCIMENTO; BEZERRA; HEBERLE, 2011) e da interseccionalidade (CRENSHAW, 2002; LIBARDI; JACKS, 2020); e c) interpretação dos dados considerando um contexto pedagógico possível para o LD, a LA e alguns pontos da Sociologia da Educação (SE). Os recursos imagéticos analisados apontaram para uma perspectiva relativamente positiva em relação à (co)existência das diversidades humanas no que diz respeito aos gêneros masculino e feminino e raças/etnias brancas/não brancas e oriental, com algumas exceções no que tange a pessoas trans/não binárias e com deficiência.
Proposta para o trabalho com os aspectos fonético-fonológicos por meio da Aprendizagem Baseada em Problemas
Authors: Machry da Silva Susiele , Brisolara Luciene Bassols
Published: May 2024

As transformações sociais e a velocidade das informações têm mudado o cenário do ensino de línguas, trazendo novos desafios e a necessidade de repensar a prática pedagógica. A necessidade de um ensino condizente com a nova realidade traz o repensar da prática pedagógica na era pós-moderna do ensino de línguas, em que, não necessariamente, se segue um único método ou abordagem, mas, sim, que seja o professor o criador de seu método, embasado em uma ou mais abordagens. Aliado a esta perspectiva, este artigo apresenta uma proposta para o ensino do espanhol a brasileiros fazendo uso da Aprendizagem Baseada em Problemas (ABP). Nosso objetivo perpassa, portanto, pelo entendimento do surgimento da Era Pós-Método no ensino de línguas (KUMARAVADIVELU, 1994; 2001), as Metodologias Ativas de Aprendizagem (BACICH; MORAN, 2018; MATTAR, 2017, entre outros), trazendo sugestões do uso da ABP para o trabalho com /s/ e /z/, pares contrastivos no português, mas não no espanhol. Defende-se, a partir desta proposta, que o uso da ABP pode levar à problematização de situações que aluno e professor busquem solucionar como participantes ativos do processo.
O signo de Libra está para seus ascendentes assim como Libras está para as classificações linguísticas
Authors: Silveira Junior Josué Shimabuko da , Borges Flávia Girardo Botelho
Published: May 2024

Este artigo apresenta aos leitores uma relação paralelística entre os termos “signo de Libra” e “Libras”, a Língua Brasileira de Sinais. O trabalho tem por objetivo discutir a classificação da Libras tendo como base categorias linguísticas quanto a aquisição/aprendizagem, oferecendo exemplos elucidativos ao longo da discussão. É possível perceber que a classificação não difere em comparação com as línguas orais, entretanto há exceções que serão discutidas, como o caso de Língua Materna e Primeira Língua. Os estudos relacionados às línguas de sinais são recentes em comparação com as demais línguas oralizadas e necessitam de mais pesquisas na área. Desta forma, partindo de um tópico da cultura popular, a Astrologia, estabelece-se a discussão sobre categorias para a classificação das línguas, em particular, a Libras.
Aula de língua inglesa e responsabilidade social: problematização de atos de corrupção no cotidiano
Authors: Barros Walter Vieira , Elono Edith Estelle Blanche Owono , Costa Marco Antônio Margarido
Published: May 2024

O objetivo deste artigo é apresentar os resultados de uma pesquisa que investigou como uma aula de língua inglesa, que visa promover discussões sobre corrupção, pode contribuir para o desenvolvimento da cidadania participativa. Fundamentamo-nos em Menezes de Souza e Monte Mór (2006), por defenderem que o objetivo do ensino de língua estrangeira na escola pública não se restringe à abordagem de aspectos linguísticos, mas está comprometido com a formação de indivíduos criativos e receptivos para novos conhecimentos e possuidores de uma consciência social. Para isso, acreditamos que tal ensino deva estar fundamentado em princípios éticos e orientado por uma perspectiva crítica. Dessa forma, a aula analisada foi planejada com o intuito de promover discussões a respeito da corrupção na sociedade e estimular a reflexão acerca de nossa responsabilidade social enquanto cidadãos. A investigação ocorreu durante o período de regência do estágio supervisionado realizado em uma turma de 3º ano do Ensino Médio de uma escola da rede estadual de ensino da Paraíba, no segundo semestre de 2016. Com a análise, percebemos que as discussões causaram desestabilização nas representações cristalizadas dos alunos sobre os atos de corrupção e de pessoas consideradas desonestas.
Reconceptualización de la dinámica del proceso de enseñanza y aprendizaje de las unidades fraseológicas en español como lengua extranjera
Authors: Villavicencio Simón Yessy , Grajales Melian Ivan Gabriel , Rosa de Melian Valdivina Telia
Published: May 2024

A contribuição deriva do projeto de tese de doutorado da primeira autora, apresentado no programa de Ciências da Educação do CEPED “Manuel F. Gran” na Universidade do Oriente, Santiago de Cuba. A revisão bibliográfica com uma abordagem qualitativa e exploratória nos permitiu explorar as contribuições teóricas e metodológicas sobre o tratamento didático das unidades fraseológicas no ensino do espanhol como língua estrangeira (NAVARRO, 2003; MADRID, 2002; BARALO, 2006; CORTINA PÉREZ, 2009; LEAL RIOL, 2011, 2012; TIMOFEEVA TIMOFEEV, 2013; ALESSANDRO, 2015; SARACHO ARNÁIZ, 2015; VILLAVICENCIO SIMÓN; TARDO; CAUSSE CATHCART, 2020; SIMÓN; MELIAN; CATHCART, 2022). Uma reconceptualização da dinâmica acima é oferecida com o objetivo de desenvolver a competência lexical no aluno do espanhol como língua estrangeira. Revela-se que há necessidade de aprimorar a formação desta competência através do estudo pragmalinguístico de tais unidades. Conclui-se que a análise epistemológica da dinâmica do processo acima mencionado é relevante, de modo que sua reconceptualização do ponto de vista pragmático pode ter repercussões na tarefa pedagógica do ensino do espanhol como língua estrangeira.
Brincadeira, engajamento e multiletramento para produção do inédito viável em um ambiente multilíngue
Authors: Liberali Fernanda Coelho , Dunkerly Rayssa Mesquita , Borges Sandra V. André , Modesto-Sarra Luciana Kool , Tiso Marina
Published: May 2024

Nosso objetivo é apresentar uma experiência de interação multilíngue em um ambiente de aprendizagem criativa, na qual os participantes foram convidados a fazer uso de suas estratégias comunicativas em um contexto multicultural. Nesta proposta, apresenta-se como os conceitos de Brincar (VYGOTSKY, 1933), Multiletramento Engajado (LIBERALI, 2021) e Multiletramento se entrelaçam para produzir o inédito viável (FREIRE, 1987) no Projeto Brincadas, uma iniciativa brasileira apoiada pela Global Play Brigade, grupo internacional de mais de 60 países, incluindo o Brasil. Este projeto surgiu como resposta às dificuldades causadas pela pandemia COVID-19. Portanto, o projeto Brincadas tenta transformar as situações limites (FREIRE, 1987), materializando novas alternativas para superar os obstáculos que se impõem no cotidiano em meio a esse contexto pandêmico da COVID-19. Nesta atividade, os participantes foram convidados a utilizar seus diferentes repertórios e experiências de vida social para recriá-los de forma mais crítica e revolucionária, ressignificando seu aprendizado e ampliando suas possibilidades de atuação. Para este artigo, nos referimos a uma experiência de Carnaval Virtual oferecida pelo Projeto Brincadas em fevereiro de 2021.
Olimpíadas do Português como Língua de Herança: relato de experiência e desafios
Authors: Moroni Andreia Sanchez , Vizentini Miriam Müller , Tanaka Luzia Miya , McCarthy Regina Pierantoni
Published: May 2024

O presente artigo busca contextualizar as I e II Olimpíadas do Português como Língua de Herança (OPLH), um concurso cultural promovido pelo governo brasileiro em 2021 e 2022 para crianças e adolescentes de origem brasileira de até 15 anos de idade em vários pontos do mundo, como parte das políticas públicas para o Português como Língua de Herança (PLH) recentemente impulsionadas pelo Brasil. Apresenta-se um relato das experiências, o qual discorre sobre: (i) o engajamento da comunidade em participar; (ii) os desafios de elaborar as provas diante das heterogeneidades características do PLH; (iii) como a ideia de ser avaliado em PLH é recebida pela comunidade; e (iv) os ajustes feitos entre a primeira e a segunda edição. A discussão se estrutura a partir de dados destas experiências em quatro localidades: o âmbito geográfico de atuação dos Consulados do Brasil em Barcelona (Espanha), Zurique (Suíça), Nagoia (Japão) e Nova York (EUA). Conclui-se que, apesar de as OPLH terem tido incialmente um caráter avaliativo e classificatório, servem como instrumento não apenas de medir conhecimentos, mas como um processo que provoca novas oportunidades de aprendizagem para os participantes, a valorização de seus saberes e a possibilidade de construir pertencimento ao universo brasileiro da diáspora.
Em torno da mesa: um espaço para a transmissão da língua e da cultura de herança
Authors: Salvatto Gabrielle Cristina Baumann , Ortale Fernanda Landucci
Published: May 2024

Este artigo tem como objetivo propor uma reflexão sobre o papel das interações em torno da mesa na preservação e transmissão intergeracional da Língua de Herança. Os dados foram gerados junto a membros do núcleo familiar Conci-Maggio, tendo em vista o contexto sui generis que o caracteriza, uma vez que, após 65 anos da chegada dos progenitores ao Brasil, o italiano ainda é a principal língua de comunicação cotidiana entre as quatro gerações. Na Introdução, são detalhados o contexto e a metodologia da pesquisa, bem como o conceito de Língua de Herança que orienta o trabalho. Em seguida, propõe-se uma discussão acerca de bilinguismo e de políticas familiares. Na terceira parte, com base na definição de Cozinha de Herança (AZEVEDO; ORTALE, 2019), apresenta-se uma análise de interações rotineiras relacionadas aos atos de cultivar ingredientes, preparar pratos e se reunir à mesa. E, finalmente, retomam-se as principais ideias do texto e, também, as potencialidades das ações cotidianas no que diz respeito às políticas de preservação da Língua de Herança.
Exploring belonging, investment and territory: a qualitative analysis of Portuguese as an Additional Language didactic materials in Brazil
Authors: Oliveira Diego Fernando
Published: May 2024

Teaching and learning Portuguese as an additional language has received progressive attention from researchers in the last two decades in the literature of Applied Linguistics in Brazil. Despite this fact, there are still gaps in language education studies that are concerned with bringing to light debates about belonging, investment and territory in language education contexts. In view of this demand, this work aims to discuss excerpts obtained from didactic materials for teaching Portuguese as an additional language, published in recent decades in Brazil, based on an integrative model that comprises the constructs of language, belonging and investment as vehicles of territoriality. Through a qualitative analysis of the treatment given to themes such as the migrant and the territory in the text fragments, the results demonstrate that it is possible to adopt strategies to foster territorialization in language education contexts for migrants by developing materials based on a critical posture to ideologies that tend to limit migrants’ agency. This paper also intends to favor the broadening of discussions in the literature about the urgency of institutionalizing Portuguese as an Additional Language in Brazil, as well as highlighting the need to (re)think teacher training in face of the reality of a contemporary Brazilian State with increasingly liquid borders.
A diachronic view of language learning strategies
Authors: Borges Laís
Published: May 2024

The present paper adopts a chronological perspective to report the development of Language Learning Strategy research in the last forty years. First, relevant strategy research is reviewed and findings from seminal studies are examined. Then, a brief overview of intervention studies is provided. Important discussions include the birth of strategy studies, controversies surrounding the field, issues in strategy training, as well as contributions from this research area to second / foreign language instruction. The paper concludes with future research directions.
The Analysis of Community Radio Performance in the Central Java Province is Conducted through the Utilization of a Radio Mobile Simulator
Authors:   Electrical Engineering, Universitas Islam Sultan Agung, Semarang, INDONESIA, Lestari Nunik , Marwanto Arief ,   Electrical Engineering, Universitas Islam Sultan Agung, Semarang, INDONESIA, Dwi Prasetyowati Sri Arttini ,   Electrical Engineering, Universitas Islam Sultan Agung, Semarang, INDONESIA
Published: May 2024

Radio broadcasting is one of the electronic media complementary to print media in the presentation of information and entertainment. Community radio is an FM radio station owned, managed, provided, initiated and established by a community. Community radio is also often referred to as social radio, educational radio, or alternative radio. Community radio frequency allocation according to the Regulations of the Minister of Communications and Informatics of the Republic of Indonesia Number: 3 In 2017, only three channels are available, namely Channels 202, 203, and 204 (frequency 107.7 MHz, 107.8 MHz and 107.9 MHz), while one channel of 200 is allocated to the Public Broadcasting Authority (LPP) and the Private Broadcaster. (LPS). Due to the limited number of community radio channels, there is not much community radio established, in addition to monitoring and optimizing the use of frequencies as well as to maintain the existence of the community radio it is necessary to conduct an analysis of the performance of those community radio. Besides, the results of the analysis also show how many channels can still be used to establish community radio in their territory. A mobile radio simulator is used to get a complete picture of the activity of the frequency channels as well as the community radio performance used in Central Java. The results of the analysis show that the community's radio frequency allocation is well used and the broadcasting power emitted in accordance with government regulations with EIRP and RSL rates is -6,02 dBm
Statistical Model for Compressive Strength of Metakaolin Concrete
Authors:   Professor, Dept of Civil Engineering, Sri Bharathi Engineering College for Women, Kaikurichi, Pudukkottai, INDIA, S Thilagavathi , Rani Padma ,   Assistant Professor, Dept of Civil Engineering, Sri Bharathi Engineering College for Women, Kaikurichi, Pudukkottai, INDIA
Published: May 2024

In the present research work, investigations were carried out to improve the performance of concrete in terms of strength by incorporating metakaolin (MK) as mineral admixture in concrete. Parametric study was carried out by considering w/c ratio, various percentage of MK and age of concrete as parameters to understand the effect of each parameter. The study was conducted for different w/c ratios of 0.32, 0.35, 0.4 and 0.5. The MK proportion was varied from 0 to 15% with an increment of 5% and age of concrete from 3 to 90 days were considered and experiments performed accordingly. The effects of above said parameters on the various properties of concrete such as workability, compressive strength and pH of concrete were investigated, and the results of metakaolin concrete were compared with the conventional concrete. From the results, it was observed that MK concrete showed greater strength for higher water cement ratios (0.4 & 0.5). A Multiple non-linear regression analysis was used to develop a statistical model to predict the strength and found to have good correlation between the observed and predicted values. It was concluded that the concrete developed in this study have significant potential for use on real time projects.
Al Based Automatic alarm Generation and Dropping of Payload at a Particular Object through a Drone
Authors:   Department of Information Technology, Greater Noida Institute of Technology (Engg. Institute), Greater Noida, INDIA, Gupta Muskan , Kumar Monu ,   Department of Information Technology, Greater Noida Institute of Technology (Engg. Institute), Greater Noida, INDIA, Singhal Dr.Vikas ,   Head,Department of Information Technology, Greater Noida Institute of Technology (Engg. Institute), Greater Noida, INDIA
Published: May 2024

Unmanned aerial vehicles (UAVs), commonly referred to as drones, are becoming more and more prevalent in a number of industries, including logistics, surveillance, and reconnaissance. This work introduces a novel framework that automatically generates alerts and precisely targets specific points of interest for UAV payload delivery using artificial intelligence (AI) algorithms. Our framework seamlessly integrates real-time object detection and recognition capabilities with an advanced AI-driven decision-making module to enable autonomous functionality. The operational process starts with using on board sensors and cameras to continuously monitor the environment. The AI algorithms carefully consider all the options when they identify an object of interest, such as a suspicious package or a predetermined target. They then determine the optimal course of action. If necessary, the system triggers an alert and arranges for a series of actions to enable the UAV to drop a payload at the designated location. Payload delivery mechanisms, advanced object detection algorithms, path planning algorithms that optimize UAV navigation, and deep learning models tailored for object recognition are some of the framework's key elements. The AI-powered decision-making module ensures that choices are made accurately, promptly, and with consideration for the mission's goals, the law, and the environment. A comprehensive evaluation of the proposed framework's efficacy is conducted through simulated and real-world experiments, showcasing its versatility in various contexts. The results Validate the framework's remarkable accuracy in object detection and recognition, as well as its reliable payload delivery capabilities. Furthermore, the system's autonomy lessens the need for human intervention, which makes it particularly suitable for applications that demand accuracy and speed. Our work advances the development of AI-powered unmanned aerial vehicles (UAVs) designed for automated monitoring, law enforcement, and disaster relief operations. With its great potential to improve situational awareness and operational effectiveness in a variety of environments, the proposed framework could usher in a new era of autonomous aerial system advancements.
STUDI PENGGUNAAN DATA GOOGLE TRENDS: KASUS PERAMALAN TINGKAT PENGANGGURAN USIA MUDA
Authors: Priyarsono D. S. , Magfirotul Laelia Siti
Published: May 2024

Google Trends data is an unbiased sample of search data produced by the Google search machine. This data represents the number of searches for a specific keyword using the search machine.  The availability of this free of charge data creates various opportunities of utilization for forecasting economic variables.  On the other hand, data produced by standard methods (using surveys) cannot be issued very frequently because of financial constraints and the limited mobility during COVID-19 pandemic.  This article reports a methodological study on the use of Google Trends data. The objective of this study is to show that the use of Google Trends data can improve the quality of forecasting.  To achieve the objective, youth unemployment data are utilized and prepared for analysis of Autoregressive Integrated Moving Average.  The quality of forecasting utilizing additional Google Trends data is compared with that without involving Google Trends data.  It is concluded that the quality of the forecasting using the first method is better than that of the second one.  This conclusion implies that utilizing Google Trends data can potentially improve the quality of forecasting and partially solve the problem of data scarcity resulted from financial constraints and the COVID-19 pandemic.
DETERMINAN DEFISIT NERACA TRANSAKSI BERJALAN DAN DEFISIT ANGGARAN: TWIN DEFICIT INDONESIA
Authors: Ludfernando Chrisna , Agung Gunanto Edy Yusuf
Published: May 2024

The global crisis has pushed Indonesia into external and internal imbalances. In this case, the current account deficit is one of the important issues related to external balance because it is related to Indonesia's foreign exchange reserves. A crisis causes not only external imbalances but also causes internal imbalances. The Indonesian government uses the State Revenue and Expenditure Budget (APBN) as an instrument in achieving internal balance, but Indonesia implements a deficit budget policy so that with this condition Indonesia experiences a twin deficit. This study aims to analyze the determinants that cause a deficit in the current account balance and government budget. The government budget, exchange rate, economic growth, commodity price index, and trade openness variables are used to analyze the current account balance determinants. Meanwhile, to analyze the determinants of the government's budget, the variables of economic growth, inflation, and interest rates are used. The analytical tool used is the Error Correction Model (ECM). The results showed that the variables of economic growth, commodity price index, and trade openness had a significant negative effect on the current account balance in the long and short term. The government budget variable has a significant positive effect in the short term on the current account balance, while the exchange rate variable has a negative and significant effect on the current account balance in the long term. In the determinants of the government budget, the variable of economic growth has a significant positive effect in the long and short term, while the inflation variable has a significant negative effect in the long and short term. However, the interest rate variable has no significant effect in the long and short term.
RANCANGAN SISTEM INFORMASI AKUNTANSI PERSEDIAAN KOPERASI PAGUYUBAN KARYAWAN DEKABE JAWA TIMUR
Authors: Nur Hidayah Titin , Yutanto Hariadi , Sihotang Ellen Theresia
Published: May 2024

The rapid development of information technology has brought changes to all aspects of individuals and organizations, one of which is cooperatives. The Cooperative Association of Pakar Dekabe employees (Pakar Dekabe Cooperative), has trading and service business activities. Its trading business activities are related to buying, selling, and managing merchandise inventory that require recording and reporting. Recording sales as inventory expenditure is still done manually. Inventory is updated at the end of the current month period. This has an impact on inventory information that is not up-to-date and there is the potential for physical discrepancies to occur in recording. In this regard, the purpose of this study is to develop an inventory accounting information system through the Excel for Accounting (EFA) application to produce financial information accurately and qualified for stakeholders. The result of this study is the design of the EFA with the development of the number of working sheets from three become 11 sheets in order to detail the recording transactions, avoid the occurrence of physical discrepancies and recording inventory and also simplify the process of preparing financial reports as part of the internal control implementation.
DO ESG-RELATED GOVERNANCE DISCLOSURES IMPROVE FIRM’S FINANCIAL PERFORMANCE IN INDONESIA?
Authors: Rahmithasari Wyandhika Muharani , Qadri Resi Ariyasa
Published: May 2024

This study endeavors to scrutinize the causality between the transparency of information within the governance pillar of sustainability performance by corporations and their financial outcomes, measured using Tobin's Q. Adopting a quantitative methodology, the research utilizes an inferential statistical testing model to analyze 275 samples derived from non-banking entities listed on the Indonesia Stock Exchange over the period from January 1, 2017, to 2021. The findings elucidate that management dedication and sustainability strategies exert a considerable adverse effect on the financial performance of companies. Conversely, the efficacy of shareholder structures appears to exert no substantial influence on financial outcomes. These results imply the critical need for corporations to meticulously consider governance aspects when devising their strategic plans. An efficacious strategy is pivotal for fostering exemplary governance practices, thereby enabling the organization to judiciously orchestrate sustainability initiatives in alignment with stakeholder perceptions
Prosthetic hand for phocomelia patients with enhanced pain management using EMG signal processing and biofeedback control system
Authors: Ravindrakumar S. , Aparna N. , Surya R. , Iniyavan S.
Published: May 2024

Denoising is an essential step in data mining. It makes an effort to remove noise from the picture without sacrificing any of the important elements. The primary method utilized in this project to assess the effectiveness of phocomelia images is Kmeans clustering. The PSNR and MSE values of the denoised image are computed. In the end, the best technique for denoising medical images is chosen based on the PSNR values from the collection of patient data necessary for the fitting of upper limb devices. Using image processing, the bone health of phocomelia patients are evaluated and specific information extracted from MRI scans. Electromyography (EMG) sensors pick up electrical impulses, convert them into hand movements that the user wants, and flex the muscles in the residual limb directly below the elbow. The same muscles that enable hand function in humans are also felt by the system using microcontrollers. Through the integration of sophisticated sensor technologies with responsive prosthetic design idea, this newly developed technique enhances feedback from the proprioceptive system for patients with phocomelia, hence promoting natural movement and improving functional outcomes. As a result, it provides phocomelia patients a special method for acquiring superior result from biofeedback system.
Impact of artificial intelligence in medical imaging
Authors: S. Atheena Milagi Pandian , Rashika Murugan , N. Sri Manoj Kumar , Sudherson M. , S. Mohammad Sahil
Published: May 2024

Artificial Intelligence (AI) is a cutting-edge technology that analyzes complex data using computer algorithms. Diagnostic imaging is one of the most potential clinical uses of AI, and increasing effort is being put toward optimizing its functionality to make a wide range of clinical problems easier to identify and quantify. Research employing computeraided diagnostics has demonstrated exceptional precision, sensitivity, and specificity in identifying minute radiographic irregularities, which has promise for enhancing public health. However, lesion identification is often used to define result assessment in AI imaging research, neglecting the nature and biological aggressiveness of a lesion. This might lead to a distorted portrayal of AI's performance. Some AI imaging research evaluate clinically significant results, whereas others compute sensitivity and specificity to quantify diagnostic accuracy. Though AI frequently picks up on little changes to images, more significant outcome factors include newly discovered advanced disease, illnesses that need to be treated, or circumstances that might have an impact on long-term survival. AI-based research should concentrate on clinically significant events since they have a significant impact on quality of life, such as symptoms, the requirement for disease-modifying medication, and death. Numerous research have demonstrated that AI outperforms normal reading in terms of specificity and recall rates; nevertheless, the kind and biological aggressiveness of a lesion are often overlooked in the estimation of accuracy and sensitivity.
Detection of deep fakes using deep learning
Authors: Anjani Suputri Devi D. , Sai Kishore T. , Venkata Sri Sai Tejaswi V. , Venkata Subrahmanya Sivaram G. , Subhan Saheb S. K. , Vikas Kumar K.
Published: May 2024

Deep learning algorithms have simplified the process of creating indistinguishable synthetic videos, or deep fakes, because of the unparalleled increase in processing power. It is concerning because these face-swapped manipulations are often used in a variety of contexts, such as blackmail and political manipulation. This paper presents a revolutionary deep learning-based approach to accurately discriminating between real and Artificial Intelligence (AI)-generated false films. Using a ResNext Convolutional Neural Network (CNN) for frame-level feature extraction, this method makes use of an automated mechanism intended to identify replacement and re-enactment deep fakes. A Recurrent Neural Network (RNN) equipped with Long Short-Term Memory (LSTM) training is utilized to classify videos and distinguish between real and modified ones. The system demonstrates the effectiveness of a straightforward and reliable methodology, in addition to utilizing complex neural network topologies. Through testing, this paper showcases how well the system can accurately identify videos playing a crucial role in ongoing initiatives to combat the increasing dangers posed by the proliferation of deep fake content in society.
Weathering the Storm
Authors:   , Allan Fletcher
Published: May 2024

The coast, a geographical area where the land meets the sea, have been inhabited by New Zealanders since the first arrival of Māori. Presently, a majority of our population resides in close proximity to the coast.

However, the escalating frequency of extreme weather events and accelerated weathering processes, attributed to climate change, is transforming the coast into a formidable and relentless environment for both people and architecture.

This thesis explores the nuanced interaction between architecture and the raw nature of coastal environments, concentrating on weathering dynamics and an intention to engage with the experience of the sublime. This investigation utilises diverse design tools to develop five architectural interventions, each tailored to interact with the distinctive weathering and sublime qualities of five specific sites along Wellington’s South Coast. Each intervention unfolds first from the conceptualisation of the bodily experience, illustrating that architecture, through its engagement with weathering processes, has the capacity to shape the sublime experience by evoking awe and managing fear. Furthermore, it is proposed that by dissolving thresholds between exposure and shelter, architecture empowers individuals to mediate their experience of the coast.

Consequently, this study acknowledges that by embracing the harsh weathering conditions of the coast, architecture facilitates an inhabitation that allows individuals to appreciate the formidable power of nature
Investigation of the CtrA cell cycle master regulator in Bartonella quintana
Authors:   , Watanabe Kae
Published: May 2024

This research project aimed to address the gaps in knowledge surrounding Bartonella quintana, with a specific focus on understanding its cell cycle dynamics and the mechanisms underlying its virulence. B. quintana is an intriguing pathogen due to its ability to persist for long periods within the human vascular and intraerythrocytic environment. Specifically, for B. quintana to reside inside erythrocytes without causing lysis, tight regulation of the cell cycle is required to limit its replication within this niche.

CtrA is known as a master regulatory protein controlling the cell cycle in multiple alpha-proteobacteria, including C. crescentus. This study aimed to shed light on how this protein influences the cell cycle or morphology of B. quintana. The primary objective was to investigate the role of CtrA as a transcription factor within B. quintana and to evaluate the impact of CtrA overexpression on the bacterium.

I first used a bioinformatics approach to identify B. quintana promoters that contained putative CtrA binding motifs. I then used a beta-galactosidase assay to investigate the impact of heterologous CtrA protein expression on the activity of two identified promoters, ftsH and ftsK. The ftsH homologue gene in C. crescentus encodes a zinc metalloprotease that is required for the stress response and that plays a role in cell division. The ftsK homologue encodes an essential protein that coordinates cell division and chromosomal segregation. The results suggested a potential repressive role of CtrA on the ftsH gene within B. quintana. Expression from the ftsK promoter, however, was not detected, either with or without CtrA.

Because CtrA is an essential protein in most alpha-proteobacteria, I attempted to construct a conditional mutant. Although this strain could not be achieved in this project, the strain carrying the complementation plasmid was used to study the effects of CtrA overexpression in B. quintana. Distinct outcomes were noted in terms of viability and chromosome content between the wildtype B. quintana and those carrying the inducible ctrA plasmid. Differences in morphology were not noted, but this could be due to the lack of time available to optimise microscopy protocols.

The alteration in viability and chromosomal contents observed, when ctrA expression was induced on a plasmid, suggests a potential role for CtrA in the cell cycle of B. quintana. Further investigation is warranted to explore the functions of CtrA in B. quintana, not only in the context of the cell cycle but also in other aspects of B. quintana morphology and pathogenesis.