bluuebunny/crossref_metadata_2025 huggingface dataset:
Gas-bearing evaluation of deep coal rock in the Yan’an gas field of the Ordos Basin
Authors: Wan Yongping , Wang Zhenchuan , Hu Dengping , Wang Ye , Huo Mengxia , Mu Xiaoyan , Han Shuangbiao
Published: September 2024

The Yan’an gas field in the Ordos Basin is a typical deep coalbed methane field with tremendous resource potential. Evaluation methods for gas content in deep coal seams are urgently required to be established. This study is aimed at quantitatively analyzing the gas content of coalbed methane in deep coalbed methane reservoirs and revealing its influencing factors. With the coal rock samples of typical deep coalbed methane wells in the Yan’an gas field of the Ordos Basin as the research objects, the gas-bearing characteristics of deep coal rocks were analyzed, and the main controlling factors of gas-bearing properties were explored. The research results indicate that (1) the deep coal seams in the Yan’an gas field have a considerable thickness, a high total organic carbon content, and the potential of pyrolysis hydrocarbon generation is generally elevated, presenting excellent hydrocarbon generation potential. (2) Various types of pores and fractures in the deep coal rocks of the Yan’an gas field are well-developed, providing a favorable preservation space and migration channel for deep coalbed methane. (3) The total gas content of on-site analysis of deep coalbed methane in the Yan’an gas field is relatively high, mainly existing in the form of free gas, and has significant exploration and development potential. (4) The gas content of deep coal rocks in the Yan’an gas field is jointly controlled by multiple factors such as the total organic carbon content, minerals, and pore structure. In conclusion, the deep coal seams in the Yan’an gas field have favorable reservoir-forming conditions and great exploration and development potential.
Hydrogen sulfide and its potential as a possible therapeutic agent in male reproduction
Authors: Pilsova Zuzana , Pilsova Aneta , Zelenkova Natalie , Klusackova Barbora , Chmelikova Eva , Postlerova Pavla , Sedmikova Marketa
Published: September 2024

Hydrogen sulfide (H2S) is an endogenously produced signaling molecule that belongs to the group of gasotransmitters along with nitric oxide (NO) and carbon monoxide (CO). H2S plays a pivotal role in male reproductive processes. It is produced in various tissues and cells of the male reproductive system, including testicular tissue, Leydig and Sertoli cells, epididymis, seminal plasma, prostate, penile tissues, and sperm cells. This review aims to summarize the knowledge about the presence and effects of H2S in male reproductive tissues and outline possible therapeutic strategies in pathological conditions related to male fertility, e. g. spermatogenetic disorders and erectile dysfunction (ED). For instance, H2S supports spermatogenesis by maintaining the integrity of the blood-testicular barrier (BTB), stimulating testosterone production, and providing cytoprotective effects. In spermatozoa, H2S modulates sperm motility, promotes sperm maturation, capacitation, and acrosome reaction, and has significant cytoprotective effects. Given its vasorelaxant effects, it supports the erection of penile tissue. These findings suggest the importance and therapeutic potential of H2S in male reproduction, paving the way for further research and potential clinical applications.
Analysis of macrophage polarization and regulation characteristics in ovarian tissues of polycystic ovary syndrome
Authors: Yuan Yue , Mao Yan , Yang Liu , Wang Yilin , Zhang Xuehong
Published: September 2024

Background

Polycystic ovary syndrome (PCOS) can lead to infertility and increase the risk of endometrial cancer. Analyzing the macrophage polarization characteristics in ovarian tissues of PCOS is crucial for clinical treatment.

Methods

We obtained 13 PCOS and nine control ovarian samples from the CEO database and analyzed differentially expressed genes (DEGs). Macrophage polarization-related genes (MPRGs) were sourced from the GeneCards and MSigDB databases. Intersection of DEGs with MPRGs identified DEGs associated with macrophage polarization (MPRDEGs). Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Protein–protein interaction (PPI) Network analysis were conducted on MPRDEGs. Moreover, the top 10 genes from three algorithms were identified as the hub genes of MPRGs. In addition, miRNAs, transcription factors (TFs), and drugs were retrieved from relevant databases for regulatory network analysis of mRNA-miRNA, mRNA-TF, and mRNA-Drug interactions. Immune cell composition analysis between the PCOS and control groups was performed using the CIBERSORT algorithm to calculate correlations across 22 immune cell types.

Results

A total of 13 PCOS samples and nine control ovarian samples were obtained in this study. We identified 714 DEGs between the two groups, with 394 up-regulated and 320 down-regulated. Additionally, we identified 774 MPRGs, from which we derived 30 MPRDEGs by intersecting with DEGs, among which 21 exhibited interaction relationships. GO and KEGG analyses revealed the enrichment of MPRDEGs in five biological processes, five cell components, five molecular functions, and three biological pathways. Immune infiltration analysis indicated a strong positive correlation between activated nature killer (NK) cells and memory B cells, while neutrophils and monocytes showed the strongest negative correlation. Further investigation of MPRDEGs identified nine hub genes associated with 41 TFs, 82 miRNAs, and 44 drugs or molecular compounds. Additionally, qRT-PCR results demonstrated overexpression of the CD163, TREM1, and TREM2 genes in ovarian tissues from the PCOS group.

Conclusion

This study elucidated the polarization status and regulatory characteristics of macrophages in ovarian tissues of the PCOS subjects, confirming significant overexpression of CD163, TREM1, and TREM2. These findings contribute to a deeper understanding of the pathogenesis of PCOS.
Intraoperative end-tidal carbon dioxide levels are not associated with recurrence-free survival after elective pancreatic cancer surgery: a retrospective cohort study
Authors: Dehne Sarah , Kirschner Lina , Klotz Rosa , Kilian Samuel , Michalski Christoph W. , Hackert Thilo , Büchler Markus W. , Weigand Markus A. , Larmann Jan
Published: September 2024

Background

Intraoperative end-tidal carbon dioxide concentrations (EtCO2) values are associated with recurrence-free survival after colorectal cancer surgery. However, it is unknown if similar effects can be observed after other surgical procedures. There is now evidence available for target EtCO2 and its relation to surgical outcomes following pancreatic cancer surgery.

Methods

In this single-center, retrospective cohort study, we analyzed 652 patients undergoing elective resection of pancreatic cancer at Heidelberg University Hospital between 2009 and 2016. The entire patient cohort was sorted in ascending order based on mean intraoperative EtCO2 values and then divided into two groups: the high-EtCO2 group and the low-EtCO2 group. The pre-specified primary endpoint was the assessment of recurrence-free survival up to the last known follow-up. Cardiovascular events, surgical site infections, sepsis, and reoperations during the hospital stay, as well as overall survival were pre-specified secondary outcomes.

Results

Mean EtCO2 was 33.8 mmHg ±1.1 in the low-EtCO2 group vs. 36.8 mmHg ±1.9 in the high-EtCO2 group. Median follow-up was 2.6 (Q1:1.4; Q3:4.4) years. Recurrence-free survival did not differ among the high and low-EtCO2 groups [HR = 1.043 (95% CI: 0.875–1.243), log rank test: p = 0.909]. Factors affecting the primary endpoint were studied via Cox analysis, which indicated no correlation between mean EtCO2 levels and recurrence-free survival [Coefficient −0.004, HR = 0.996 (95% CI:0.95–1.04); p = 0.871]. We did not identify any differences in the secondary endpoints, either.

Conclusions

During elective pancreatic cancer surgery, anesthesiologists should set EtCO2 targets for reasons other than oncological outcome until conclusive evidence from prospective, multicenter randomized controlled trials is available.
A prediction model to differentiate transient ischemia from irreversible transmural necrosis in closed-loop small bowel obstruction
Authors: Pan Shaorong , Yang Jiejin , Liu Zining , Nai Rile , Chen Zeyang
Published: September 2024

Introduction

The study aims to develop a prediction model to differentiate transient ischemia from irreversible transmural necrosis in closed-loop small bowel obstruction (CL-SBO).

Methods

A total of 180 participants with CL-SBO between January 2010 and December 2019, of which 122 had complete radiologic data, were included to investigate the significant clinical and imaging characteristics for differentiating patients with necrosis from transient ischemia. A logistic regression model was developed and validated.

Results

In a multivariate analysis, the American Society of Anesthesiologists physical status classification system >2 is the independent predictor for transmural necrosis. Another multivariate analysis, including clinical and imaging factors, revealed that the imaging sign of mesenteric vessel interruption was an independent risk factor for necrosis. The diagnostic model developed using these two factors has excellent performance among the validation sets, with an area under the curve of 0.89.

Conclusion

The diagnostic model and innovative imaging signs have substantial potential in solving this complex clinical problem.
Mechanisms of ferroptosis and the relationship between ferroptosis and ER stress after JEV and HSV infection
Authors: Zhou Rui , Wei Kexin , Li Xinyu , Yan Beibei , Li Lin
Published: September 2024

Ferroptosis is a novel form of programmed cell death, which is different from apoptosis, pyroptosis and autophagy in morphology and biochemistry. Ferroptosis is characterized by condensed mitochondrial membrane densities, vanished of mitochondria crista and outer membrane rupture in morphology, and the accumulation of intracellular iron, lipid peroxidation (LPO), decrease of GSH and inhibition of GPX4 in biochemistry. Japanese encephalitis virus (JEV) and Herpes simplex virus (HSV) are both common neurotropic viruses that can cause neurological disorders, such as severe encephalitis. JEV and HSV have been demonstrated to be able to induce ferroptosis. This process is closely related to the inhibition of the GSH-GPX4 system, ACSL4 phosphorylation, and Nrf2 ubiquitination. In this review, we summarized the mechanisms by which JEV and HSV induced ferroptosis in the current study. In addition, we found a strong relationship between endoplasmic reticulum (ER) stress and ferroptosis, and we therefore speculated that sustained ER stress might be a prerequisite for ferroptosis in JEV and HSV-induced diseases.
Antimicrobial resistance and genomic analysis of Vibrio parahaemolyticus isolates from foodborne outbreaks, Huzhou, China, 2019–2023
Authors: Yan Wei , Ji Lei , Dong Fenfen , Chen Liping , Yuan Rui , Zhang Peng
Published: September 2024

Objective

The purpose of this study was to investigate the epidemiological and genomic characteristics of Vibrio parahaemolyticus (V. parahaemolyticus) isolates from outbreaks in Huzhou, China.

Methods

This study aims to analyze the epidemiological data on V. parahaemolyticus outbreaks reported in Huzhou from 2019 to 2023. A total of 70 V. parahaemolyticus outbreak isolates were collected. The antibiotic resistance, serotypes, molecular typing, and genomic characteristics of these isolates were analyzed.

Results

Most outbreaks of V. parahaemolyticus infection occurred in the summer, and the majority of outbreaks occurred in restaurants and rural banquets. High resistance rates were observed for ampicillin (AMP, 24.29%), followed by tetracycline (TET, 15.71%) and trimethoprim-sulfamethoxazole (SXT, 15.71%). The newly emerged serotype O10:K4 became dominant from 2021 to 2023, with most isolates belonging to ST3. The resistance gene blaCARB was frequently detected among these isolates. The pulsed-field gel electrophoresis (PFGE) and whole-genome single-nucleotide polymorphisms (wgSNPs) effectively differentiated the nine outbreaks.

Conclusion

The newly emerged serotype O10:K4 became dominant from 2021 to 2023, with most isolates being ST3. PFGE and WGS technologies provided reliable methods for typing and identifying V. parahaemolyticus for outbreaks.
Unveiling the vital role of soil microorganisms in selenium cycling: a review
Authors: Jiang Zhihui , Wang Zhiyong , Zhao Yong , Peng Mu
Published: September 2024

Selenium (Se) is a vital trace element integral to numerous biological processes in both plants and animals, with significant impacts on soil health and ecosystem stability. This review explores how soil microorganisms facilitate Se transformations through reduction, oxidation, methylation, and demethylation processes, thereby influencing the bioavailability and ecological functions of Se. The microbial reduction of Se compounds, particularly the conversion of selenate and selenite to elemental Se nanoparticles (SeNPs), enhances Se assimilation by plants and impacts soil productivity. Key microbial taxa, including bacteria such as Pseudomonas and Bacillus, exhibit diverse mechanisms for Se reduction and play a substantial role in the global Se cycle. Understanding these microbial processes is essential for advancing soil management practices and improving ecosystem health. This review underscores the intricate interactions between Se and soil microorganisms, emphasizing their significance in maintaining ecological balance and promoting sustainable agricultural practices.
Association between blood pressure and dementia in older adults: a cross-sectional study from China
Authors: Yi Tingting , Su Zhou , Wang Jiyang , Gan Jinghuan , Wu Hao , Shi Zhihong , Sun Zhen , Liu Shuai , Ji Yong
Published: September 2024

Background and aims

The association between blood pressure (BP) and dementia in older adults remains unclear, prompting this study to investigate the relationship between various BP indicators and dementia in this population.

Methods

A cross-sectional survey was conducted in 2019, including 3,599 participants aged 65 years or older. The basic demographic characteristics of participants were collected. BP measurements and neuropsychological assessments were performed. From the systolic BP (SBP) and diastolic BP (DBP) values, mean arterial pressure (MAP), pulse pressure (PP) and blood pressure index (BPI) were calculated. Generalized additive models and logistic regression models were used to analyze the association between BP indicators and dementia.

Results

Generalized additive models identified a U-shaped relationship between DBP and dementia, which was more significant in males and people 70 years of age and older. The optimal DBP associated with the lowest dementia risk was 85 mmHg. Logistic regression models revealed that compared to the DBP subgroup (80–89 mmHg), participants in the DBP < 80 mmHg subgroup and the DBP ≥100 mmHg subgroup had OR for dementia of 1.611 (95% CI: 1. 252–2.073, P < 0.001) and 1.423 (95% CI: 0.999–2.028, p = 0.050), respectively. A significant association was observed between BPI and dementia (OR:1.746 95% CI: 1.142–2.668, p = 0.010).

Conclusion

In older adults, we found a U-shaped relationship between DBP and dementia, and a linear relationship between BPI and dementia. These results underscore the importance of considering DBP and BPI in BP management strategies for older adults to potentially prevent or delay dementia onset.
New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer’s disease
Authors: Cao Yuan , Zhao Lin-Wei , Chen Zi-Xin , Li Shao-Hua
Published: September 2024

Alzheimer’s disease (AD) is increasingly recognized as being intertwined with the dysregulation of lipid metabolism. Lipids are a significant class of nutrients vital to all organisms, playing crucial roles in cellular structure, energy storage, and signaling. Alterations in the levels of various lipids in AD brains and dysregulation of lipid pathways and transportation have been implicated in AD pathogenesis. Clinically, evidence for a high-fat diet firmly links disrupted lipid metabolism to the pathogenesis and progression of AD, although contradictory findings warrant further exploration. In view of the significance of various lipids in brain physiology, the discovery of complex and diverse mechanisms that connect lipid metabolism with AD-related pathophysiology will bring new hope for patients with AD, underscoring the importance of lipid metabolism in AD pathophysiology, and promising targets for therapeutic intervention. Specifically, cholesterol, sphingolipids, and fatty acids have been shown to influence amyloid-beta (Aβ) accumulation and tau hyperphosphorylation, which are hallmarks of AD pathology. Recent studies have highlighted the potential therapeutic targets within lipid metabolism, such as enhancing apolipoprotein E lipidation, activating liver X receptors and retinoid X receptors, and modulating peroxisome proliferator-activated receptors. Ongoing clinical trials are investigating the efficacy of these strategies, including the use of ketogenic diets, statin therapy, and novel compounds like NE3107. The implications of these findings suggest that targeting lipid metabolism could offer new avenues for the treatment and management of AD. By concentrating on alterations in lipid metabolism within the central nervous system and their contribution to AD development, this review aims to shed light on novel research directions and treatment approaches for combating AD, offering hope for the development of more effective management strategies.
Relationship between residual cholesterol and cognitive performance: a study based on NHANES
Authors: Liu Kepeng , Fu Haishou , Chen Yong , Li Binfei , Huang Huaqing , Liao Xiaozu
Published: September 2024

Background and aims

Age-related cognitive impairment impacts a significant portion of the elderly population. Remnant cholesterol (RC) has attracted increased attention in relation to cardiovascular disease, diabetes, hypertension, and fatty liver disease. Nevertheless, its role in cognitive function is still enigmatic, prompting our exploration into the potential associations between them.

Methods

A total of 1,331 participants from the NHANES (2011–2014) database, all aged over 60, were included in this investigation. Cognitive function was assessed using four widely applied tests, including the Consortium to Establish a Registry for Alzheimer’s Disease Word Learning (CERAD-WL), CERAD Delayed Recall (CERAD-DR), Animal Fluency Test (AFT), as well as Digit Symbol Substitution test (DSST). Z-score is calculated by scores from the above four tests. The association between RC, total cholesterol (TC) to RC and cognitive performance was assessed by logistic regression analyses. In addition, restricted cubic spline (RCS) regression was performed to assess non-linearity between RC and cognitive function. Subgroup analysis was performed to evaluate the robustness of the results in populations with relevant covariate variables.

Results

Those with Z-scores below the 25% quartile are defined as having cognitive impairment, totaling 498 individuals. Observationally, higher RC levels and a lower TC/RC were associated with an increased risk of cognitive impairment. After adjusting for confounding factors, the impact of RC levels on cognitive performance quartiles was consistent across various subgroups, except in individuals with trouble sleeping, no/unknown alcohol use, and no hypertension. Americans with high RC levels and trouble sleeping are more likely to develop cognitive impairment, with an odds ratio of 2.33 (95% CI: 1.18–4.59).

Conclusion

This study suggests that higher RC levels and lower levels of TC/RC are associated with an increased likelihood of cognitive impairment, suggesting that RC can serve as a novel and convenient indicator for predicting the risk of cognitive impairment in the US population.
Comparative study of CAD/CAM reconstruction and miniplates for patient-specific fixation in LCL-type mandibular reconstruction
Authors: Lampert Philipp , Fenske Jakob , Wüster Jonas , Koerdt Steffen , Kreutzer Kilian , Ruf Philipp , Checa Sara , Heiland Max , Steffen Claudius , Rendenbach Carsten
Published: September 2024

Objective

Miniplates offer superior clinical handling and facilitate postoperative removal after mandibular reconstruction but unfavorable load distribution under high stress has been shown. This study aimed to compare the clinical outcome of patient-specific 3D-printed (PS-3D) titanium miniplate with reconstruction plate fixation in three-segmental LCL-type reconstructions for the first time.

Methods

Patients undergoing three-segmental LCL-type mandibular reconstruction after malignant tumor resection between April 2017 and July 2023 were analyzed in a retrospective single-center study. Inclusion criteria were primary reconstruction using a fibula free flap and PS-3D titanium mini- or reconstruction plate fixation. Complication rates were recorded and analyzed within 6 months after surgery using the N – 1 Chi2- and unequal variance t-test.

Results

38 patients (10 females, 28 males; mean age 61.4 ± 7.6 years) met the inclusion criteria. In 14 patients (36.8%) miniplates were used in the anterior region. Rates of fixation failure, plate exposure, incomplete osseous union, wound infection, soft tissue, and overall complications did not differ significantly between the two plate systems.

Conclusion

Complication rates did not differ significantly between PS-3D mini- and reconstruction plates in three-segmental LCL-type mandibular reconstructions. Given their advantages in clinical handling and postoperative removal, PS-3D miniplates can be a viable alternative also in larger mandibular reconstructions.
Qingxuan Runmu Yin alleviates dry eye disease via inhibition of the HMOX1/HIF-1 pathway affecting ferroptosis
Authors: Wang Jiadi , Liu Yue , Zong Beiting , Zhao Shanshan , Li Yue , Zhang Zhirui , Yao Jing
Published: September 2024

The prevalence of dry eye disease (DED), a multifactorial ocular surface disease characterized by tear film instability, is increasing yearly. Qingxuan Run Mu Yin (QXRMY) is a traditional Chinese medicine (TCM) consisting of Radix Rehmanniae, Radix Scrophulariae, Rhizoma Atractylodis macrocephalae, Herba Dendrobii, Flos Lonicerae, Forsythia suspensa, Ophiopogon japonicus, Saposhnikovia divaricata, Radix Platycodi, and Radix Glycyrrhizae. It has excellent therapeutic effects on dry eye syndrome and a good anti-inflammatory effect on immune-related inflammation. However, the molecular mechanism of Qing Xuan Run Mu Yin in treating dry eye syndrome is largely unknown. The present study used an online database to identify potential target genes of QXRMY for treating DED. The possible mechanisms of these target genes for the treatment of DED were obtained through Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) databases, Hub genes screened by Cytoscape and intersected with ferroptosis-related genes, and the essential genes were finally obtained based on the results of the analyses. DED cell model and rat model were constructed in this study to validate the critical genes and pathways, and it was confirmed that QXEMY alleviated DED by repressing ferroptosis through inhibiting the HMOX1/HIF-1 pathway. In conclusion, this study integrated network pharmacological analyses and experimental validation to provide an effective method to investigate the molecular mechanism of QXRMY in treating DED.
Rosa × damascena Herrm. essential oil: anti-tyrosinase activity and phytochemical composition
Authors: Wu Qiuyan , Fang Wanting , Liu Hao , Liu Zhong , Xu Xuetao
Published: September 2024

Tyrosinase is a key enzyme in melanin synthesis, and its natural inhibitors are receiving increasing attention. Rosa × damascena Herrm. essential oil (RDEO), as important functional metabolites, was widely known due to its biological activities. But its tyrosinase inhibitory activity has not been detailed investigated. Therefore, in this paper, RDEO was comprehensively investigated the tyrosinase inhibitory, followed by the phytochemical composition analysis. Activity screening results showed that RDEO exhibited effective anti-tyrosinase activity and was a reversible and mixed-type inhibitor. CD assay results revealed that RDEO could affect the conformation of tyrosinase to reduce the activity. In B16F10 cells, RDEO (25–100 μg/mL) could inhibit intracellular tyrosinase activity and decrease melanin content. Finally, GC-MS analysis of RDEO found that citronellol (21.22%), geraniol (14.1%), eicosane (11.03%), heneicosane (6.65%) and 1-nonadecene (5.16%) were its main phytochemical compositions. This study provided data support for Rosa × damascena Herrm. essential oil as one potential natural tyrosinase inhibitor and its applications in cosmetics and medicine.
A single intraarticular injection of a tranexamic acid-modified hyaluronic acid (HA/TXA) alleviates pain and reduces OA development in a murine model of monosodium iodoacetate-induced osteoarthritis
Authors: Brochard Sybille , Boumédiene Karim , Mercier Jéromine , Agin Véronique , Conrozier Thierry , Baugé Catherine
Published: September 2024

Rationale

Tranexamic acid (TXA) is a strong and specific plasminogen activator inhibitor with inhibitory effects on the matrix metalloproteases involved in the pathophysiology of osteoarthritis (OA) through targeting of the fibrinolysis pathway. In this study, we evaluated the analgesic and chondroprotective effects of a HA-tranexamic acid (HA/TXA) conjugate, compared to HA alone and placebo, in an animal model of knee OA.

Methods

Knee OA was induced in 15 C57 b l/6J mice by IA injection of 0.75 mg of Monosodium IodoAcetate (MIA). At day 28, the mice received 1 IA injection of 10 µL of saline (control-group), or of HA or of HA/TXA. Tactile sensitivity was assessed using von Frey filaments. Stimulations started at 1 g and increased until a response was obtained (up to 4 g). A response to the stimulus was counted if the animal withdrew its paw. If the animal responded to the 1 g stimulation, stimulation was reduced until the lack of response was observed (up to 0.2 g). At day 56, mice were euthanized for knee histological assessment. Cartilage degradation was assessed using the OARSI score. Statistical analysis was performed on GraphPad Prism 8.0.2 software. Kruskal–Wallis or Mann-Whitney tests were performed as appropriate.

Results

Just before treatment administration, no intergroup difference in paw withdrawal threshold was observed. Throughout the experiment animals given saline and HA had a lower paw withdrawal threshold than those treated with HA/TXA (p < 0.01). In the control group OARSI score was 5.5 ± 0.6. In HA and HA + TXA treated mice the OARSI score was 3.2 ± 0.8 and 3.1 ± 0.5 (p < 0.01) showing that both treatments were able to reduce OA progression.

Conclusion

In this animal model of MIA induced KOA, a single IA injection of a HA/TXA conjugate resulted in a greater efficacy on pain than both saline and HA. HA and HA/TXA exhibited chondroprotective effects compared to placebo.
Family language policy retention across generations: childhood language policies, multilingualism experiences, and future language policies in multilingual emerging Canadian adults
Authors: Pagé Leah L. , Noels Kimberly A.
Published: September 2024

Introduction

Language policies in multilingual families refer to parents’ decisions, whether explicitly articulated or not, regarding which languages will be used in which contexts. However, because most studies that explore language allocation focus on families with young children, they do not address how family language policies impact the retention of a home language through to the next generation. The present study investigates an important perspective on this issue, specifically how emerging adults’ childhood experiences with their family language policy relate to the languages they currently use and plan to retain in the future.

Methods

In all, 62 multilingual Canadian adults, aged between 17 and 29 years, participated in focus group interviews concerning their experience of language policies in their birth families, their current beliefs concerning language allocation and retention, and their plans about language policy in their future families.

Results

The data revealed that not only are most participants interested in retaining their home language, thereby continuing to speak the language in their future families, but most are also open to incorporating additional languages into their policies.

Discussion

The results provide insight into how to identify effective heritage language retention policies that transcend generations.
Why should I when no one else does? A review of social norm appeals to promote sustainable minority behavior
Authors: Schorn Anna
Published: September 2024

Social norm appeals have been proven successful in promoting sustainable behavior that most people engage in. However, research on the effectiveness of social norm appeals in promoting sustainable behavior performed by a numerical minority of people is lacking. This systematic review aimed to examine empirical studies that applied social norm appeals and to elaborate on how social norm appeals could be effectively designed to foster sustainable minority behaviors. Thirty-six articles, including 54 studies, applying social norm interventions to promote sustainable minority behavior were compiled and discussed, with a particular focus on the methodology and operationalization of social norm appeals. The results showed that static descriptive minority social norm appeals might not be effective in promoting sustainable behavior. Nevertheless, there appeared to be differences depending on the strength of the norm and the environmental attitudes of the population. However, using injunctive and dynamic descriptive social norm appeals appear promising approaches because these appeals are less prone to undesirable effects. Nevertheless, it could be problematic if injunctive and descriptive social norm appeals are not aligned, but results are inconclusive. For practitioners, emphasizing social change and highlighting majority approval are simple, low-cost strategies with great potential to induce compliance and encourage sustainable minority behavior without running the risk of backfire effects.
On research into the relationship between personality traits and the sporting level of competitive, professional and elite athletes
Authors: Piepiora Paweł Adam , Čaplová Petra , Zimoń Paweł , Gumienna Róża
Published: September 2024

Data on the relationship between personality traits and athletes’ level of sportsmanship are not sufficiently documented. Therefore, it is reasonable to look for differences in personality traits between athletes from different levels: amateur, competitive and professional, as these groups of athletes function differently on a daily basis. Therefore, the aim of this article was to gain knowledge about the relationship between personality traits and the sporting level of athletes. The experiment examined male and female athletes (N = 119) aged 19–34, including 100 Polish professional athletes: 30 basketball players, 40 football players, 30 kyokushin style karate competitors; and 19 professional athletes (among them were the elite: 3 Olympic medallists): 4-person Polish Biathlon Team, 7-person Polish Luge Team, 8-person Swiss Mountain Bike (MTB) Team. The NEO-FFI Personality Questionnaire was used. Analyses were performed with the IBM SPSS Statistics 29.0 package at a statistical significance of α = 0.05. Significant differences were found in comparisons between groups of athletes: football players and karate competitors (in severity of neuroticism, extraversion, agreeableness, conscientiousness), football players and basketball players (in severity of neuroticism, extraversion, openness to experience, conscientiousness), football players and lugers (in severity of agreeableness), football players and mountain bikers (in severity of neuroticism). One significant difference was noted in the comparisons between athletes from different levels: competitive athletes had higher neuroticism severity than elite athletes. A weak and negative correlation between neuroticism and sporting levels was verified. But no correlation was shown between personality traits and the likelihood of becoming a professional. It was concluded that the observed differences between the studied groups of athletes could be derived from the specifics of the different sports. The elite are characterised by a lower intensity of neuroticism in relation to the competitive athletes, which can be seen in the relationship: the lower the neuroticism, the higher the sporting level.
Substance use among young people in sub-Saharan Africa: a systematic review and meta-analysis
Authors: Ebrahim Jemal , Adams Jon , Demant Daniel
Published: September 2024

Background

The use of substances such as alcohol, tobacco, khat, or drugs among young people is becoming a public health concern globally, with particularly high prevalence rates in low and middle-income settings, where socio-cultural and economic factors contribute to distinct challenges in addressing this problem. This review aimed to summarize the current literature on the prevalence of substance use among young people in sub-Saharan Africa (SSA) and identify gaps in the current body of literature.

Methods

Seven databases and Google were searched for studies reporting on substance use prevalence among young people (aged 10-24 years) in SSA, published between January 2010 and May 2024. Observational studies were included, assessed for methodological quality, and checked for the presence of heterogeneity and publication bias using standard methods. A random effect model was used to estimate the pooled proportions for substance use among young people.

Results

The literature search identified 1,889 hits from the databases and Google. Among these 60 eligible studies involving 83,859 respondents were included in the review. The overall lifetime, 12-month, and current prevalence of any substance use among young people in SSA was found to be 21.0% (95% CI= 18.0, 24.0), 18% (95% CI=10,27), and 15% (95% CI=12,18), respectively. Among young people from SSA, alcohol use problem was the most prevalent (40%), followed by khat use (25%), stimulant use (20%), and cigarette smoking (16%). Other substances used by a smaller proportion of young people included cannabis, cocaine, inhalants, sedatives, shisha, hallucinogens, steroids, and mastics. The prevalence of substance use problems was higher among males compared to females, highest in the southern African region followed by Western and Eastern regions, and in community-based studies compared to institutional-based studies.

Conclusions

In SSA, over a fourth of young people use at least one substance in their lifetime, with higher rates among males than females and in community-based compared to institution-based studies. These results emphasize the need for interventions targeting the wider young population and those in specific subgroups identified as being at higher risk of substance use. This approach allows for the provision of tailored support and resources to those who need it most while also promoting positive health outcomes for the entire population of young people in the region.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022366774, identifier CRD42022366774.
Modernizing undergraduate medical education by bringing public health into focus
Authors: Hothersall Eleanor J.
Published: September 2024

Healthcare and healthcare education are changing rapidly, being pulled in a number of directions by political, economic, environmental and technological imperatives. At the University of Dundee Medical School a curriculum review during the Covid-19 pandemic has allowed opportunities to reframe aspects of the program to emphasize themes linking public health and social determinants of health to the wider curriculum, while also bringing a shared understanding of the core outcomes of the program. This brings some adaptability into the structure and content of the course, helping graduates and staff to be “future proof.”
OLTW-TEC: online learning with sliding windows for text classifier ensembles
Authors: Lipianina-Honcharenko Khrystyna , Bodyanskiy Yevgeniy , Kustra Nataliia , Ivasechkо Andrii
Published: September 2024

In the digital age, rapid dissemination of information has elevated the challenge of distinguishing between authentic news and disinformation. This challenge is particularly acute in regions experiencing geopolitical tensions, where information plays a pivotal role in shaping public perception and policy. The prevalence of disinformation in the Ukrainian-language information space, intensified by the hybrid war with russia, necessitates the development of sophisticated tools for its detection and mitigation. Our study introduces the “Online Learning with Sliding Windows for Text Classifier Ensembles” (OLTW-TEC) method, designed to address this urgent need. This research aims to develop and validate an advanced machine learning method capable of dynamically adapting to evolving disinformation tactics. The focus is on creating a highly accurate, flexible, and efficient system for detecting disinformation in Ukrainian-language texts. The OLTW-TEC method leverages an ensemble of classifiers combined with a sliding window technique to continuously update the model with the most recent data, enhancing its adaptability and accuracy over time. A unique dataset comprising both authentic and fake news items was used to evaluate the method’s performance. Advanced metrics, including precision, recall, and F1-score, facilitated a comprehensive analysis of its effectiveness. The OLTW-TEC method demonstrated exceptional performance, achieving a classification accuracy of 93%. The integration of the sliding window technique with a classifier ensemble significantly contributed to the system’s ability to accurately identify disinformation, making it a robust tool in the ongoing battle against fake news in the Ukrainian context. The application of the OLTW-TEC method highlights its potential as a versatile and effective solution for disinformation detection. Its adaptability to the specifics of the Ukrainian language and the dynamic nature of information warfare offers valuable insights into the development of similar tools for other languages and regions. OLTW-TEC represents a significant advancement in the detection of disinformation within the Ukrainian-language information space. Its development and successful implementation underscore the importance of innovative machine learning techniques in combating fake news, paving the way for further research and application in the field of digital information integrity.
Sustainability materiality of insuring coal businesses for insurers
Authors: Umakanth Mithula
Published: September 2024

This study aims to understand the impact of sustainability efforts on materiality or financial performance of insurers by accounting their risk coverage pattern in the Coal Mining Industry. 10 major insurance companies have been selected for this study and the focus has been to understand the stances and policies implemented by these companies between 2018 and 2023. Some of the firms like Hartford have officially declared that they have exited from this industry, while major players are still fueling the coal mining industry. Alternatively, companies themselves are looking to fund their risk mitigation plans so as to not rely on insurance firms. Studies by Hinshaw Law show that losses arising from climate change are rising at an alarming rate, the question then remaians, would insurance companies continue to fund activities that would put their existence in peril. Further research can be conducted on a larger time frame, new policies and frameworks implemented across this industry and to understand the risks of insuring activities that have increased the rate of climate change.
Hong Kong anti-human trafficking framework: what lessons can be learned from Europe?
Authors: Lo Noble Po-kan
Published: September 2024

This article examines the regulatory framework related to human trafficking in Hong Kong and identifies its deficiencies as the lack of an accepted internationally compliant definition of trafficking and the absence of any specific criminal offence of trafficking as a result. The article compares the approach taken in Hong Kong to efforts undertaken in Europe by the Council of Europe, the UK, and the European Union and identifies several lessons from the European experience that could help rectify failures observed in Hong Kong. In particular, effective combatting of human trafficking requires not only a definition of the offence that recognises the essential elements—an “act,” a “means,” and a “purpose” of exploitation—but also the establishment of sufficient state institutions and agencies dedicated to identifying and protecting trafficking victims. Without the detection of trafficking victims, criminals engaged in the act of trafficking perceive their chances of being caught and prosecuted as low and operate with impunity. This necessitates the adoption of a consistent and readily identifiable criminal offence of “trafficking” aligned with the approach taken by the Palermo Protocol, just as the EU and UK have done.
Incidence of enamel defects on permanent canine teeth following extraction of linguoverted mandibular deciduous canine teeth in dogs
Authors: Felz Charles L. , Arzi Boaz , Taney Kendall , Block Katherine
Published: September 2024

Interceptive orthodontics may be indicated in puppies exhibiting dental malocclusion with linguoverted deciduous mandibular canine teeth to alleviate pain and prevent teeth interlock, which may affect growth and development of the mandibles. Historically extraction of deciduous mandibular canine teeth has been recommended as soon as a malocclusion is identified, often as early as 6–8 weeks of age and no later than 12 weeks of age. This early surgical intervention of deciduous teeth extractions risks potential damage to the developing permanent canine teeth resulting in enamel defects often referred to as a Turner’s tooth or Turner’s hypoplasia. A search of medical records from five veterinary specialty dentistry practices was conducted to identify dogs 8–12 weeks of age who (a) underwent deciduous mandibular canine extractions for management of class 1 or class 2 malocclusion with linguoverted mandibular canine teeth, and (b) were seen for at least one recheck exam to assess for enamel defects on permanent mandibular canine teeth. Furthermore, data was collected to determine the number of dogs that required additional treatment after eruption of the permanent canine teeth due to linguoversion of the permanent canine teeth. All procedures were performed by a board-certified veterinary dentist™ or a supervised veterinary dentistry resident. Seventy-four dogs fit the inclusion criteria and had a total of 143 deciduous mandibular canine teeth extracted, out of which 13 dogs exhibited enamel defects affecting 21 permanent canine teeth. The 13 affected dogs represent a 17.5% cumulative incident rate 13/74 (95%CI 11–28%). Of all extracted teeth, 14.6% (21/143) had enamel defects affecting permanent canine teeth. Twenty-eight dogs required additional treatment to prevent the permanent mandibular canine teeth from causing trauma to the hard palate and gingiva which represented 37.8% (28/74) of all dogs in the study. Age and sex of the dog at the time of extraction were not found to be associated with the likelihood of incidence of enamel defects. This is the first reported rate of enamel defects on permanent mandibular canine teeth following extraction of deciduous mandibular canine teeth and is important to consider when advising or performing extraction of deciduous teeth in dogs.
Study on the Performance Improvement of Straw Fiber Modified Asphalt by Vegetable Oil
Authors: Ma Hongfu , Jiao Xiaolei , Liu Xinjie , Zhao Song , Gong Minghui , Zhang Qianhui , Ouyang Jian
Published: September 2024

As a plasticizer, vegetable oil can improve the compatibility between straw fibers and an asphalt matrix and promote the uniform dispersion of fibers, thereby improving the viscoelastic properties of the composite material. This paper selected three vegetable oils: tall oil, rapeseed oil, and palm wax. Through dynamic shear rheology tests, low-temperature bending beam rheology tests, contact angle tests, and infrared spectroscopy tests, the vegetable-oil-reinforced straw fiber modification was analyzed from different points of view. The research results show that palm wax significantly improves the high-temperature rheological properties of straw-fiber-modified asphalt but has a negative impact on low-temperature properties. Tall oil can most significantly improve the low-temperature rheological properties of straw-fiber-modified asphalt. Rapeseed oil has the most obvious effect in improving the adhesion and water damage resistance of straw-fiber-modified asphalt. In addition, the research shows that all three vegetable oils exist in the modified asphalt in adsorbed form, and no new compounds are generated. These research results provide theoretical guidance value for the application of straw-fiber-modified asphalt pavement in different environments.
An Analog Integrated Multiloop LDO: From Analysis to Design
Authors: Koniavitis Konstantinos , Alimisis Vassilis , Uzunoglu Nikolaos , Sotiriadis Paul P.
Published: September 2024

This paper introduces a multiloop stabilized low-dropout regulator with a DC power supply rejection ratio of 85 dB and a phase margin of 80°. It is suitable for low-power, low-voltage and area-efficient applications since it consumes less than 100 μA. The dropout voltage is only 400 mV and the power supply rails are 1 V. Furthermore, a full mathematical analysis is conducted for stability and noise before the circuit verification. To confirm the proper operation of the implementation process, voltage and temperature corner variation simulations are extracted. The proposed regulator is designed and verified utilizing the Cadence IC Suite in a TSMC 90 nm CMOS process.
Genetic and Epigenetic Factors That Predispose to Musculoskeletal Disorders
Authors: Raleigh Stuart M.
Published: September 2024

Musculoskeletal soft tissue disorders (MSTDs) are a heterogenous group of maladies that can affect the muscles, bones, nerves, joints, ligaments, tendons, cartilage, and adjoining structures and seriously impact on the quality of life in those affected [...]