bluuebunny/crossref_metadata_2025 huggingface dataset:
Maintaining Customer Loyalty Using Electronic Customer Relationship Management (E-CRM): Qualitative Evidence from Small Food Businesses in Jordan
Authors: Kakeesh Dana , Al-Weshah Ghazi , Al-Ma'aitah Noor
Published: July 2021

The current study aims at providing understanding and practical insights of how to maintain customer loyalty using E-CRM from perspectives of small food businesses in Jordan. The qualitative design of research is adopted. Semi-structured and face-to-face interviews have been conducted with eight executives to generate data from target interviewees in different Jordanian food companies. Using thematic analysis for interviews and based on executives perspectives, this study provides customer loyalty concepts, benefits, tools, and measurements. Moreover, this study also investigates the benefits of E- CRM, E-CRM tools, and how customer loyalty could be enhanced by E-CRM. The results of the thematic analysis found that social media and telemarketing are the most common tools of E-CRM that are adopted by food companies. Sales frequency and sales records are the most common criteria for customer loyalty measurement. Furthermore, complaints handling, post sales services, customer following up, and maintaining customer relationship are the most critical tactics of E-CRM that are adopted by food companies to enhance customer loyalty. The study recommends that customer loyalty practices are not well established by food companies; however, adopting E-CRM practices are critical issues for maintaining customer loyalty.
The choice of tactical approaches to the implementation of enterprise strategy in terms of innovative development
Authors: Doroshkevych Kateryna , Maslak Oleksander , Motorniuk Uliana , Zhezhukha Volodymyr , Terebuh Marta , Malinovska Оlga
Published: July 2021

In order to increase the level of efficiency of strategic management of the enterprise as a result of strategy implementation by means of various tactical approaches, the article investigates methods and models for selecting tactical approaches to strategy implementation: enterprise strategy and tactics tree (S&T tree), marginal approach to the choice of tactics, hidden Markov model, method of morphological analysis, etc. Critical analysis of the methods has proved the necessity of combining them in order to increase the effectiveness of the mathematical apparatus, which is designed to reduce the subjectivity, which is inherent in heuristic methods (provided by most of the studied methods).In order to achieve the goals of the article, it is recommended the procedure for choosing tactical approaches to implementing the strategy: definition of the purposes and tasks, information maintenance of process of a choice of the tactical approach; formation of a set of strategic approaches for realization of strategy of the enterprise for what it is possible to use elements of a suffix tree; selection of criteria for acceptability of the tactical approach (Boolean variables that characterize the costs of the enterprise and the implementation of the tactical approach, the level of prices for finished products and services, market capacity in which the company operates, the level of market competition, international economic relations) and their expert evaluation; formation of a table of values of the Boolean function of an acceptable tactical approach to implementing enterprise strategy and evaluating the Boolean vector number; formation of an evaluation scale depending on the set of tactical approaches of the enterprise; selection tactical approach on the recommended scale.The practical implementation of the recommended procedure at TMC «Lvivholod» Ltd. (the company is one of the leaders in the retail trade of Western Ukraine with more than ten years of experience in retail, it ranks 5th place in the all-Ukrainian ranking of networks by number of outlets) has allowed to choose a tactical approach, which involves the transformation of existing products in the enterprise, the formation of their new features and subspecies that can meet the different needs of consumers, the development of quality characteristics of the enterprise's products, excellent product properties..
Improving the quality of higher education based on the positive image of HEE in the social and information space: legal and management aspects
Authors: Horodovenko Viktor , Bilovodska Olena , Vatras Volodymy , Kanzafarova Ilona , Melnyk Roman
Published: July 2021

In the paper the authors improved the methodological approach to quantitative assessment of the image of a higher education establishment (HEE). This approach is based on the structure of the image of higher education establishment (educational process quality, training costs, visual characteristics of higher education establishments, stability of student intake and employment graduates, educational and extracurricular work as for applicants, corporate culture and traditions) for selected target audiences, provides comprehensive assessment and takes into account the significance (weight) of selected parameters evaluation. The image of higher education establishments was evaluated for three groups of the target audience: applicants, their parents and first-year students of higher education establishments of Ukraine. It was based on the real data of existing higher education establishments of Ukraine and EU, and online survey of 756 people. The author's approach is important for the general approach to the management of the HEE image, analysis and selection of forms, methods, mechanisms and tools of such management, search and justification of the place and role of image management in the management of the entire higher education establishment.
Modeling of economic security of the enterprise at change of investment maintenance
Authors: Bondarenko Svitlana , Tkachuk Halyna , Klochan Iryna , Mokhnenko Andrey , Liganenko Iryna , Martynenko Vasyl
Published: July 2021

The purpose of this study is formation of tools for forecasting the economic security of the enterprise by modeling methods when changing investment support. The relevance of this study is due to the need to solve the problem of modernization management system of the enterprise by implementing the project management of economic security of the enterprise in the implementation of investment programs.The variant of model offered economic security of the enterprise. This model involves the implementation of the process of adaptive management, based on the definition of safe limits of longterm growth of the enterprise. It has established that the ratio of self-organization processes and managerial influences depends on the value of the self-organization coefficient. The calculated value of adaptive potential on the basis of the indicator of self-organization as the dynamic indicator of maintenance of perspective growth of the enterprise on the allocated purposes has offered. This indicator can serve as a criterion for assessing the effectiveness of the management system of the enterprise in relation to the project management of economic security of the enterprise in the implementation of investment programs of key goals of long-term growth of the enterprise.
Organizational Barriers which are Facing Electronic Government Implementation: The Electronic Government Implementation Framework
Authors: Saleh Saman , A. Nakshabandi Omar , Zeebaree Mosleh , Ismael Goran Yousif , Aqel Musbah
Published: July 2021

Investigating e-government specified a few organizational barriers to e-government implementation. This paper proposes a framework for examining how organizational barriers affect the application of e-government. Frame creation depends on three main organizational dimensions. First, the organizational main dimensions, which are related to the culture of the organization, include (control system, strategic direction, integration, and coordination). Second, the organizational main dimensions which are related to the structure of the organization include (adaptability, involvement, integration, agreement, reword, and incentive system). Third, the organizational main dimensions, which are related to Information Technology, include (information transfer, Communication, end-user focus, and employee learning). We initiate those organizational obstacles which are recognized in major electronic government literature linked to the organizational culture effectiveness and dimensions. The conclusion is that the framework is related to understand organizational barriers which prompt the implementation of electronic government. This research is limited to the framework that has been developed based on the lens of e-government literature in the application theory. It is now necessary to test this model in different contexts. This study tries to demonstrate that key that impedes the factors that are associated with the implementation and enhancement of the e-government system. There must be more attention to the progress made in e-government projects quickly and accurately. Thus, there is a strong commitment on the part of each government to implement e-government services.
Lithostratigraphy of the Naros Granite (Komsberg Suite), South Africa and Namibia
Authors: Macey P.H. , Thomas R.J. , Smith H.P. , Frei D. , le Roux P.J.
Published: July 2021

The Naros Granite occurs as a large, northwest-trending ovoid batholith roughly 30 km long and 15 km wide straddling the Orange River border between South Africa and Namibia, 25 km northeast of Onseepkans. It consists mainly of a leucocratic to mesocratic grey, coarse-grained equigranular hornblende-biotite granite-granodiorite that is locally mildly feldspar porphyritic. Small, ovoid mafic autoliths are common and characteristic of the Naros Granite. The composition of the unit varies from granite to granodiorite with a minor leucogranitic phase observed along the southern margin of the batholith. Hornblende and biotite are ubiquitous mafic minerals but small amounts of orthopyroxene occur locally. The Naros Granite has yielded tightly-constrained U-Pb zircon ages between 1 114 Ma and 1 101 Ma.

The Naros Granite is generally unfoliated to weakly deformed with only localised shearing along contacts with the surrounding country rocks giving rise to orthogneissic fabrics. It has an intermediate to felsic composition (mean SiO2: 63.9 ± 2.2 wt.%) and is strongly metaluminous. This, together with its biotite-hornblende ± orthopyroxene mineral assemblage and the abundance of mafic autoliths, suggests it is an I-type granitoid, with the source magma produced by partial melting of older igneous rocks that had not undergone any significant chemical weathering.

The Naros Granite is the youngest and most evolved member of the ~1.11 Ga Komsberg Suite, a collection of late- to post-tectonic I-type metaluminous, intermediate to felsic, biotite ± hornblende granitoids and their charnockitic equivalents that have intruded the older pre-tectonic gneisses of the Kakamas Domain of the Namaqua Metamorphic Sector.
Covid-19’s Emotional Toll on Students: Experiences during Online Assessments in an Open and Distance Learning Programme
Authors: du Plessis Elize , van der Westhuizen Gert
Published: July 2021

The Covid-19 pandemic had an immense effect on teaching and learning during 2020. The fast shift to online examinations in reaction to the pandemic and subsequent lockdown underlines the significance of motivationally enriched and emotionally supportive instruction during this stressful time. It cannot be assumed that all students have the same access to online assets or to internet-equipped devices such as laptops or tablets. Not all students coped well, as an analysis of student remarks indicated in a qualitative study. The purpose of this exploratory case study was to determine what type of emotions Postgraduate Certificate in Education students experienced during their first fully online examination in order to create motivating and supportive learning environments. A total of 10 of these students from an open and distance learning university were purposefully selected to complete 14 questions related to their learning needs and, in particular, emotional challenges during the lockdown. Theoretical underpinnings include, inter alia, five motivational design principles. The results indicated that all 10 students had access to mobile phones and seven to laptops to participate in online academic activities. The emotions experienced most by the students varied from anxiousness to restlessness. The findings are discussed with reference to supporting students’ motivation and emotions in university courses during these stressful times.
Entomologists – the Austro-Hungarian army prisoners of World War I in Siberia and the Russian Far East
Authors:   Khabarovsk Territorial Museum after N.I. Grodekov, Khabarovsk, Russia, Novomodnyi E.V. , Beljaev E.A. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Published: July 2021

The participation of European entomologists from among the Austro- Hungarian army prisoners of World War I in the research of the Siberian and Amur entomofauna is considered. Despite the fact that they were doing this in conditions of lack of freedom, their mass collection yielded appreciable results. The biographical information about Karl Ferdinand Mandl (1891– 1989), Stepan Jurechek (1877–1940), Hermann Frib (1877–1947), Josef Michel (1890–1963) and Alfred Biener (1892(?)–1954), which are known from publications of entomologists processed their collections or materials, is given. Some little-known events from the activities in the South Ussuriysk branch of the Amur department of the Russian Geographical Society in Nikolsk-Ussuriysk, and in the life of Evgenia Nikolaevna Klobukova-Alisova (1889–1962) and Alexei Ivanovich Kurentsov (1896–1975) are described. The translation of memories on this time by A. Biener is included in the Appendix.
Review of the family Caligidae (Crustacea, Сореpoda, Siphonostomatoida) of the fauna of Vientam
Authors:   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Kovaleva N.N. , Kazachenko V.N. ,   Far Eastern State Technical Fisheries University, Vladivostok, Russia
Published: July 2021

An annotated list of 30 species in 10 genera of the family Caligidae collected from fishes in the waters of Vietnam in 1960, 2011, 2013 is given. The data on localities and hosts are provided for all species. Vietnamese Caligidae is registrated from 29 fishe species from 26 genera, 21 families, and six orders. The most diverse genera of copepods are Caligus (16 species) and Parapetalus (4 species). Tropical and subtropical species of Caligidae dominate in the fauna of Vietnam, while only Caligus bonito, C. pelamydis, C. lacustris and Caligodes laciniatus are distributed in both Boreal and Subtropical zones.
Distribution of two species of dung-beetles (Coleoptera: Scarabaeidae, Aphodiini) in Primorsky krai
Authors:   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Shabalin S.A.
Published: July 2021

The use of the method of removing the substrate allows not only to obtain new information about the structure of assemblies of coprophagous beetles, but also to clarify the distribution of certain species. In Russia, two species of dung-beetles were previously known only from the Khasansky district of the Primorsky krai. At present, Aganocrossus urostigma (Harold, 1862) is found in the Shkotovsky district, and Sinodiapterna songrini (Stebnicka et Galante, 1992) is reported from the Shkotovsky, Partizansky, and Anuchinsky districts of Primorsky krai for the first time.
Reversal of cognitive, behavioral, and language impairments after the left frontal arachnoid cyst fenestration in a pediatric patient
Authors: Maxwell Christina R. , Joshi Neal , Feller Christina N. , McAree Michael , Hedayat Hirad S.
Published: July 2021

Background:

Arachnoid cysts (ACs) are cerebrospinal fluid-containing cysts located between the surface of the brain or spinal cord and arachnoid layer of the leptomeninges. ACs have been known to cause cognitive, language, and behavioral deficits and currently there is no standard treatment paradigm. Surgical indications include papilledema, increasing growth with mass effect causing neurological deficit, or rapid head growth, however, cognitive symptoms related to mass effect may not always be considered.

Case Description:

We present a 3-year-old male with an AC of the left anterior fossa causing frontal lobe compression with resultant behavioral, language, and cognitive deficits.

Conclusion:

Surgical intervention for AC decompression may be indicated when there are cognitive, behavioral, or language delays related to the mass effect and location of the AC. Neuropsychiatric testing or more advanced imaging studies may further support surgical treatment. After craniotomy for fenestration of the left frontal AC, there was drastic improvement in cognitive, language, and behavioral symptoms in our pediatric patient.
Surgical histopathology of a filar anomaly as an additional tethering element associated with closed spinal dysraphism of primary neurulation failure
Authors: Morioka Takato , Murakami Nobuya , Suzuki Satoshi O. , Mukae Nobutaka , Shimogawa Takafumi , Kurogi Ai , Shono Tadahisa , Mizoguchi Masahiro
Published: July 2021

Background:

Closed spinal dysraphism of primary neurulation failure could be associated with filar anomalies, such as filar lipoma or thickened and tight filum terminale (TFT), resulting from impaired secondary neurulation. Retained medullary cord (RMC) is a remnant of the cavitary medullary cord originating from the secondary neurulation failure. Some filar lipomas are known to contain a central canal-like ependyma-lined lumen with surrounding neuroglial tissues (E-LC w/NGT), that is, a characteristic histopathology of RMC. To clarify the embryological background of these filar anomalies, we evaluated the histopathological findings.

Methods:

Among 41 patients with lesions of primary neurulation failure who underwent initial untethering surgery, the filum including cord-like structure (C-LS) was additionally resected in 10 patients (five dorsal and transitional lipomas; five limited dorsal myeloschisis). We retrospectively analyzed the clinical, neuroradiological, intraoperative, and histopathological findings.

Results:

Among 10 patients, two patients were diagnosed with RMC based on morphological features and intraoperative neurophysiological monitoring. The diagnosis of filar lipoma was made in six patients, since various amounts of fibroadipose tissue were histopathologically noted in the filum. Two patients were diagnosed with TFT, since the filum was composed solely of fibrocollagenous tissue. E-LC w/NGT was noted not only in both C-LSs of RMCs but also in two out of six fila both with filar lipomas and fila with TFTs.

Conclusion:

These findings provide further evidence for the idea that entities, such as filar lipoma, TFT, and RMC, can be considered consequences of a continuum of regression failure occurring during late secondary neurulation.
Multiple hippocampal transections for mesial temporal lobe epilepsy
Authors: Pitskhelauri David , Kudieva Elina , Kamenetskaya Maria , Kozlova Antonina , Vlasov Pavel , Dombaanai Baiyr , Eliseeva Natalia , Shishkina Lyudmila , Sanikidze Alexander , Shults Evgeniy , Moshev Dmitriy , Pronin Igor , Melikyan Armen
Published: July 2021

Background:

The purpose of this study was to evaluate the effectiveness of multiple hippocampal transections (MHT) in the treatment of drug-resistant mesial temporal lobe epilepsy.

Methods:

Six patients underwent MHT at Burdenko Neurosurgery Center in 2018. The age of the patients varied from 18 to 43 years. All patients suffered from refractory epilepsy caused by focal lesions of the mesial temporal complex or temporal pole in dominant side. Postoperative pathology revealed neuronal-glial tumors in two patients, focal cortical dysplasia (FCD) of the temporal pole – in two patients, cavernous angioma – in one patient, and encephalocele of the preuncal area – in one patient.

Results:

All patients underwent surgery satisfactorily. There were no postoperative complications except for homonymous superior quadrantanopia. This kind of visual field loss was noted in four cases out of six. During the follow-up period five patients out of six had Engel Class I outcome (83.3%). In one case, seizures developed after 1 month in a patient with FCD in the uncus (Engel IVA). After surgery, three out of six patients developed significant nominative aphasia. Two patients relative to the preoperative level demonstrated improvement in delayed verbal memory after MHT. Two patients showed a decrease level in delayed verbal memory. In preoperative period, visual memory was below the normal in one patient. Delayed visual memory in two cases impaired compared to the preoperative level.

Conclusion:

MHT can be considered as an effective method of drug-resistant mesial temporal lobe epilepsy caused by tumors of the medial temporal complex. At the same time, MHT makes it possible to preserve memory in patients with structurally preserved hippocampus. However, MHT do not guarantee the preservation of memory after surgery.
Delayed Collet-Sicard syndrome after internal carotid dissection and Jefferson fracture. Case report and Review of Literature
Authors: Al-Shabibi Talal , Hamdi Hussein , Balaha Ahmed , Ghoraba Yasser , Kaya Jean-Marc
Published: July 2021

Background:

Lower cranial nerve palsies, or Collet-Sicard syndrome, can be caused by many different etiologies including head trauma, basilar occipital fractures, tumors, and interventions. Few reports describe different presentations of this condition, and we present here a case study to increase awareness of and add to the variable spectrum.

Case Description:

A 56-year-old who had been hit while diving was admitted to our department. On examination, he was conscious without any signs of lateralization but presented with severe neck pain. CT brain and cervical spine revealed a C1 fracture with bilateral symmetrical fracture of the anterior and posterior arches (Jefferson’s fracture) and slight bilateral joint dislocation C1-C2 discreetly predominant on the left. One week later, he presented with dysarthria, dysphonia, swallowing disorder, anisocoria, tongue deviation, and palate deviation (XII, IX, and X). CT Angiography showed dissection of the internal carotid artery immediately after the carotid bulb. He has been treated conservatively with curative anticoagulants with stable symptoms. No surgical intervention had been proposed.

Conclusion:

Adding to the literature, delayed Collet-Sicard syndrome and lower cranial affection can be caused by missed carotid wall hematoma following severe craniocervical trauma associated with Jefferson’s fracture.
Third ventricle colloid cysts: An endoscopic case series emphasizing technical variations
Authors: Zymberg Samuel Tau , Riechelmann Guilherme Salemi , da Costa Marcos Devanir Silva , Ramalho Clauder Oliveira , Cavalheiro Sergio
Published: July 2021

Background:

Colloid cyst treatment with purely endoscopic surgery is considered to be safe and effective. Complete capsule removal for gross total resection is usually recommended to prevent recurrence but may not always be safely feasible. Our objective was to assess the results of endoscopic surgery using mainly aspiration and coagulation without complete capsule resection and discuss the rationale for the procedure.

Methods:

A retrospective review was conducted of 45 consecutive symptomatic patients with third ventricle colloid cysts that were surgically treated with purely endoscopic surgery from 1997 to 2018.

Results:

Mean age was 35.4 years. Male-to-female ratio was 1:1. Clinical presentation included predominantly headache (80%). Transforaminal was the most used route (71.1%) followed by transeptal (24.5%) and interforniceal (4.4%). Capsule was intentionally not removed in 42 patients (93.3%) and cyst remnants were absent on postoperative MRI in 36 (85%). Mild complications occurred in 8 patients (17.8%). Surgery was statistically associated with cyst volume and ventricular size reduction. There were no serious complications, shunts or deaths. Follow-up did not show any recurrence or remnant growth that needed further treatment.

Conclusion:

Gross total resection may not be the main objective for every situation. Subtotal resection without capsule removal seems to be safer while preserving good results, especially in a limited resource environment. Remnants left behind should be followed but tend to remain clinically asymptomatic for the most part. Surgical planning allows the surgeon to choose among the different resection routes and techniques available. Decisions are predominantly based on preoperative imaging and intraoperative findings.
Cytokines, brain proteins, and growth factors in acute stroke patients: A pilot study
Authors: Zafar Atif , Farooqui Mudassir , Ikram Asad , Suriya Sajid , Kempuraj Duraisamy , Khan Mohammad , Tasneem Nudrat , Qaryouti Dania , Quadri Syed , Adams Harold P. , Ortega-Gutierrez Santiago , Leira Enrique , Zaheer Asgar
Published: July 2021

Background:

Immunomodulation and cell signaling involve several cytokines, proteins, and other mediators released in response to the trauma, inflammation, or other insults to the central nervous system. This pilot study is part of the registry designed to evaluate the temporal trends among these molecules after an acute ischemic stroke (AIS) in patients.

Methods:

Twelve AIS patients were enrolled within 24 hours of the symptoms onset. Two sets of plasma samples were collected: First at admission and second at 24 hours after admission. Cytokines/chemokines and other inflammatory molecules were measured using multiplex assay kit.

Results:

An increased trend in IL-6 (22 vs. 34 pg/ml), IL-8/CXCL8 (87 vs. 98 pg/ml), MMP-9 (16225 vs. 18450 pg/ml), and GMF-β (999 vs. 3739 pg/ml) levels was observed overtime after an AIS. Patients ≤60 years had lower levels of plasma MCP-1/CCL2 (50–647 vs. 150–1159 pg/ml), IL-6 (9–25 vs. 20–68 pg/ml), and IL-8 (30– 143 vs. 72–630 pg/ml), when compared with patients >60 years old.

Conclusion:

Cytokines/chemokines and other inflammatory mediators play an important role in the pathogenesis of stroke in addition to mediating poststroke inflammation. Further research is needed to evaluate and characterize the cumulative trends of these mediators for the clinical prognosis or as surrogate biomarkers.
Waste not, want not: Report of a completely calcified C1-C2 juxtafacet cyst and literature review
Authors: Ruggeri Luca , Brunasso Lara , Urrico Giovanni , Alessandrello Raffaele , Cinquemani Giovanni , Lipani Rita , Mandelli Jaime , Nobile Francesco , Iacopino Domenico Gerardo , Maugeri Rosario
Published: July 2021

Background:

Calcified juxtafacet cysts in the cervical spine are extremely rate. Such symptomatic cysts commonly cause neck pain, radiculopathy, or even myelopathy. MR and CT studies typically document cord/ root compression. On occasion, some of these cysts will spontaneously regress, while many others may warrant surgical removal.

Case Description:

A 70-year-old male presented with a 2-year history of a progressive tetraparesis. The preoperative MR/CT studies showed a C1-C2 left extradural mass occupying more than half of the spinal canal. On MR, it was homogeneously hypointense on both T1- and T2-weighted images, while the CT showed a calcified cyst. Intraoperative and histopathological findings documented a calcified cervical juxtafacet cyst (i.e. ganglion subtype) that was fully excised without sequelae.

Conclusion:

C1-C2 juxtafacet cervical cyst should be considered when a patient presents with myelopathy due to a calcified MR/CT documented paraspinal lesion contributing to significant cervical cord/root compression.
THE ABILITY OF STUDENTS’ CONCEPTUAL UNDERSTANDING IN COMPLETING STORY PROBLEMS ON MATHEMATICS
Authors: Mayasari Dian , Habeahan Nova Lina Sari
Published: July 2021

This study aims to describe the ability of students to understand concepts in solving story problems. The research subjects were 28 grade VII students of SMP Negeri 8 Merauke. Data collection techniques were carried out in tests of students' abilities in understanding concepts and unstructured interviews. The test used to measure the concepts is in the form of description questions and 4 questions with integer operation material on the story problem. From the data analysis, it was concluded that the students' ability at high ability could master the 6 indicators of concept understanding, students in the moderate category mastered 5 indicators of concept understanding, students in the low category mastered 4 indicators of conceptual understanding. It can be concluded that the students' concept understanding ability is in the medium category.
Repercussion of piperine on pharmacokinetics parameters of eletriptan in albino rats: Involvement of CYP3A and P-GP inhibition
Authors: Hematheerthani N  , Siva Reddy CH  , Prameela Rani A  , Suresh Kumar P
Published: July 2021

Eletriptan is at the type of triptan medication suggested for the management of episodes of severe headache with or without aura. Piperine (1-piperoylpiperidine) is a pure alkaloid as well as the basic tanginess material from the pipli and peppercorn. There are signs that piperine inhibits Cytochrome P-450 enzymes and P-glycoprotein, rather than arouses, drug metabolism generally, thus increasing the bioavailability and effect of several medications. The analysis was undertaken to assess the results of Piperine on the pharmacokinetics of Eletriptan. Samples of blood were taken at different time points for example 0 (predose), 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 6.0, 8.0, 12, 24 hours post-treatment. The plasma concentration of Eletriptan was estimated with the HPLC procedure.  In our study Cmax, Tmax, AUC0-24 , AUC0-8, AUC%, AUMC0-24, AUMC0-8, t1/2, MRT0-24, MRT0-8 and Volume of distribution were increased by approximately 51.76%, 7.55%, 72.93%, 84.42%, 42.72%, 93.56%, 128.82%, 19.97%, 11.74%, 23.96% and 3% respectively, where as clearance decreased by 42.10% when eletriptan co-administered with piperine. In summary, the results obtained herein imply that Piperine is improving the bioavailability of Eletriptan by strengthening the exposure (AUC) of their Eletriptan when concomitantly administered by the oral route. The Piperine improved the oral bioavailability of eletriptan by inhibiting CYP3A and P-GP in rats. This observation indicates the possibility that the combo of piperine along with other CYP3A and P-GP double substrates can also enhance bioavailability.
Dynamic changes in RNA–protein interactions and RNA secondary structure in mammalian erythropoiesis
Authors: Shan Mengge , Ji Xinjun , Janssen Kevin , Silverman Ian M , Humenik Jesse , Garcia Ben A , Liebhaber Stephen A , Gregory Brian D
Published: July 2021

Two features of eukaryotic RNA molecules that regulate their post-transcriptional fates are RNA secondary structure and RNA-binding protein (RBP) interaction sites. However, a comprehensive global overview of the dynamic nature of these sequence features during erythropoiesis has never been obtained. Here, we use our ribonuclease-mediated structure and RBP-binding site mapping approach to reveal the global landscape of RNA secondary structure and RBP–RNA interaction sites and the dynamics of these features during this important developmental process. We identify dynamic patterns of RNA secondary structure and RBP binding throughout the process and determine a set of corresponding protein-bound sequence motifs along with their dynamic structural and RBP-binding contexts. Finally, using these dynamically bound sequences, we identify a number of RBPs that have known and putative key functions in post-transcriptional regulation during mammalian erythropoiesis. In total, this global analysis reveals new post-transcriptional regulators of mammalian blood cell development.
Towards a Left Secretariat for the Pacific
Authors: Bryar Tim
Published: July 2021

The Pacific Islands region occupies a vast ocean continent, consisting of a diversity of cultures. What draws the islands together is a shared experience of economic dependency and vulnerability driven by global warming, geopolitical competition, and class divisions. Together, these factors account for poor performance on a range of development indicators, including policy and inequality. It is in this context that Epeli Hau‘ofa has argued that the hoped-for era of autonomy following political independence has not materialised in the Pacific. In response, this paper explores the possibilities and potential aims of a Left secretariat in the Pacific. It aims to rethink political and economic autonomy in the Pacific by bringing together Left theory and practice with the history of Indigenous and class struggles.
A NEW HYBRID PRP-MMSIS CONJUGATE GRADIENT METHOD AND ITS APPLICATION IN PORTOFOLIO SELECTION
Authors: Devila Sindy , Malik Maulana , Giyarti Wed
Published: July 2021

In this paper, we propose a new hybrid coefficient of conjugate gradient method (CG) for solving unconstrained optimization model.  The new coefficient is combination of part the MMSIS (Malik et.al, 2020) and PRP (Polak, Ribi'ere \& Polyak, 1969) coefficients.  Under exact line search, the search direction of new method satisfies the sufficient descent condition and based on certain assumption, we establish the global convergence properties.  Using some test functions, numerical results show that the proposed method is more efficient than MMSIS method.  Besides, the new method can be used to solve problem in minimizing portfolio selection risk .
Qualitative Content Analysis of Teachers’ Perceptions and Experiences in Using Blended Learning during the COVID-19 Pandemic
Authors: Batac Kenneth Ian Talosig , Baquiran Jonnedel Azucena , Agaton Casper Boongaling
Published: July 2021

The unexpected COVID-19 pandemic has closed schools and shifted the mode of education to digital and distance learning methods. However, the socioeconomic status of students affects their access to education. Blended learning, which includes online classes, television and radio broadcasts, and modular lessons, offers a more inclusive education that caters to the needs of the students. While the subject has been discussed in the literature from the perspective of the learners, this paper explores the perceptions, experiences, and insights of teachers in the Philippines on blended learning at the time of the pandemic. This study surveyed 39 basic education teachers and analyzed the data using qualitative content analysis. The results showed an agreement on teachers' perspectives about the effectiveness of educational policies implemented and the government's response to the pandemic. Despite the flexibility in using blended learning, the teachers experienced various challenges in applying this method during the pandemic, such as readiness, technology literacy, access to technology, financial difficulties, and health risk. These findings suggest the government and other education stakeholders provide additional financial support to schools during the pandemic; enhance the professional development activities for teachers; and continue developing learning platforms allowing open access to quality and reliable educational resources during and beyond the pandemic.
Effect of Body Mass Index on Serum CA125 Level in Females with PCOS
Authors: Hasan Hanan Abdulmaged , Selman Mohammed Oda , Jwad Mufeda Ali
Published: July 2021

CA125 is a glycoprotein mucins (MUC16) tumor marker, used in screening, ovarian and endometrial malignancies and in monitoring therapy, early recurrences, and prognosis of these cancers. Hormonal induction for ovulation can elevate the risk of ovarian cancers so CA125 may be used for screening in PCOS as an unsafe group and the way of treatment may need to be changed in these patients. Polycystic Ovarian Syndrome (PCOS) is one of the most common hormonal disturbed diseases that can affect females in reproductive life. It has both metabolic and fertility impacts that can be seen in the reproductive period and post-menopausal life. To study the correlation between PCOS and CA125 level in relation to body weight in non-cancerous patients. 60 women were selected with age 18-42-year-old forty of them were diagnosed with PCOS according to Rotterdam criteria. They were divided into two groups according to BMI G1 was more than 25 kg/m2 (overweight and obese) G2 was less than 25 kg/m2 (normal) and the G3 was 20 healthy non-PCOS BMI less than 25 kg/m2. Blood samples were taken in the early follicular phase for assessing luteinizing hormone (LH), follicular stimulating hormone (FSH) and, free testosterone (FT) hormone. Other blood samples were taken at the late follicular phase to measure CA125 levels using Enzyme-Linked Immune Sorbent Assay (ELISA). PCOS G2 were significantly higher in the concentration of CA125 than PCOS G1 (p< 0.05), but there was no significant difference in CA125 level in groups when there is no significant difference in body mass index (BMI) between PCOS G1 and G2. P>0.05. The negative relation between CA125 concentration and weight. The tumor marker CA125 efficacy is decreased in obese women. Furthermore, PCOS not causes an increase in CA125 in the non-cancerous patient.
Пацієнтоцентричність фізичної терапії під час спортивно-реабілітаційних зборів
Authors: Andriichuk Olga , Ulianytska Nataliia , Hreida Nataliia , Strubitska Nataliia
Published: July 2021

Актуальність. Реалізація комплексної програми реабілітації спортсменів після травм та ушкоджень, окрім виділення мети, цілей, завдань, контролю ефективності й спостереження, повинна враховувати можливість відновлення спортивної майстерності, підвищення вмотивованості до комплексної реабілітації, переоцінку своїх можливостей і перспектив. Мета дослідження – аналіз динаміки показників якості життя за анкетою МОS SF-36 у спортсменів, які проходили двотижневий курс фізичної терапії за індивідуально реалізованим реабілітаційним планом під час спортивно-реабілітаційних зборів. Методи дослідження – аналіз і синтез наукових літературних джерел, педагогічне спостереження, дворазове анонімне анкетування МОS SF-36; статистичне опрацювання даних. Результати дослідження. Аналіз отриманих даних на початку дослідження за анкетою МОS SF-36 із виділенням фізичного компонента здоров’я (PCS) та психологічного компонента здоров'я (MCS) у показнику якості життя показав значну варіабельність даних: PCS – від 25,79 до 59,76 бала; MCS – від 20,97 до 64,85 балів. При цьому між показниками простежено негативний кореляційний зв'язок помірної сили. Після двотижневої програми фізичної терапії, яка складалась з урахуванням профілю пацієнта відповідно до МКФ й була спрямована не лише на підвищення рівня функціонування та ліквідацію (компенсації, відновлення) наслідків травм й ушкоджень опорно-рухового апарату, а й на задоволення потреб і побажань спортсменів, варіабельність компонентів здоров’я, змінилась. Величина PCS коливалась у межах від 34,31 до 59,48 бала, MCS – від 21,43 до 61,77 бала. Між показниками PCS та MCS наприкінці дослідження з’явився слабкий позитивний кореляційний зв’язок. Також ми аналізували взаємозалежність між компонентами здоров’я на початку та наприкінці досліджен- ня. Виявлено за показниками PCS позитивний кореляційний зв'язок помірної сили. Водночас між показниками MCS на початку й наприкінці дослідження залежності не виявлено. Висновки. Доведений кореляційний зв'язок між показниками PCS на початку дослідження та після реалізації програми фізичної терапії є свідченням того, що врахування принципу пацієнтоцентричності під час складання індивідуального реабілітаційного плану є обов’язковою умовою результативності реабілітації. Зміна коефіцієнта кореляції між показниками PCS і MCS із негативного помірної сили на позитивний слабкої сили свідчить про те, що реалізовані реабілітаційні плани, провідним принципом яких був пацієнтоцентричний підхід, відобразилися на складниках якості життя, змінюючи їх взаємовплив та взаємозалежність.
Формування здоров'язбережувальної компетентності майбутніх фахівців будівельних спеціальностей в процесі професійно-прикладної фізичної підготовки
Authors: Melnyk Serhii
Published: July 2021

Актуальність. Доведено основні напрями реалізації стану сформованості здоров’язберігальної компетент- ності в професійній підготовці майбутніх фахівців будівельних спеціальностей у процесі професійно-прикладної фізичної підготовки, що в подальшому уможливило вивчення динаміки зміни її сформованості. Також уста- новлено причини низького рівня сформованості здоров’язберігальної компетентності майбутніх фахівців будівельних спеціальностей. Обґрунтовано, що структурними компонентами здоров’язберігальної компетентності майбутніх фахівців будівельних спеціальностей є аксіологічний, гносеологічний і фізкультурно-оздоровчий. Мета дослідження полягає у визначенні та обґрунтуванні критеріїв і показників рівня сформованості здоров’язберігальної компетентності майбутніх фахівців будівельних спеціальностей у процесі професійно- прикладної фізичної підготовки. Методи дослідження – вивчення, аналіз і систематизація літературних джерел, узагальнення передового педагогічного досвіду для визначення важливості формування в майбутніх фахівців будівельних спеціальностей здоров’язберігальної компетентності в процесі професійно-прикладної фізичної підготовки. Результати роботи. На основі кількісних і якісних показників проведено порівняльний аналіз отриманих результатів експерименту. Достовірність результатів дослідження забезпечувалася науковою обґрунтованістю вихідних теоретичних положень; внутрішньою логікою дослідження; адекватністю методів, які вико- ристовувалися, метою й завданням дослідження; використанням статистичних методів обробки результатів роботи. Висновки. На теоретичному та методологічному рівні доведено важливість професійно-прикладної фізичної підготовки для формування здоров’язберігальної компетентності майбутніх фахівців будівельних спеціальностей. Визначено структурні компоненти, критерії сформованості та ступінь сформованості здоров’язберігальної компетентності, а також показники, які характеризують сформованість кожного критерію.
Вегетативне забезпечення функціонального резерву серця підлітків різних медичних груп
Authors: Sitovskyi Andrii , Bielikova Natalia , Indyka Svitlana , Radchenko Oleksandr , Romaniuk Viktor , Savchuk Ihor
Published: July 2021

Актуальність. Фізична працездатність підлітків різних медичних груп варіює в досить широких діапазонах. Розподіл учнів на медичні групи за показниками індексу Руф’є не відображає рівня фізичної працездатності школярів. Мета дослідження – дослідити взаємозв’язок вегетативного забезпечення серцевої діяльності, фізичної працездатності та функціонального резерву серця підлітків різних медичних груп. Матеріал та методи дослідження. Обстежено 140 школярів 7–8-х класів віком 12–14 років (середній вік – 12,9±0,65 років). Із них 58 хлопців (середній вік – 12,9±0,7 років) та 82 дівчини (середній вік – 13,0±0,6 років). Вивчали фізичну праце- здатність (PWC170), функціонально-резервні можливості серцево-судинної системи (індекс Руф’є), варіабельність ритму серця (ВРС). Статистичний аналіз здійснювали за допомогою пакета прикладних програм Statistica-v.10.0. Результати. Під час вивчення вегетативного забезпечення серцевої діяльності встановлено достовірні відмінності між основною й спеціальною медичними групами за такими показниками ВРС у спокої: LF norm, n.u., HF norm, n.u., LF/HF, у.о., %LF. Середні показники К 30:15 між різними медичними групами не відрізнялися. А їхні середні значення перебували в діапазоні 1,0–1,25 у.о., що характеризує погіршення функціонального стану організму в усіх медичних групах. Баланс симпатичного й парасимпатичного відділів ВНС, за середніми даними приросту ЧСС в ортопробі, перебували в межах фізіологічної норми (18–27 %) і не відрізнявся між різними медичними групами. Висновки. У стані спокою простежено переважання активності симпатичної ланки регуляції в модуляції серцевого ритму підлітків спеціальної медичної групи, порівняно з основною. Однак за активної ортостатичної проби відсутні відмінності між показниками, що характеризують стан вегетативної регуляції серцевої діяльності й реактивність симпатичного та парасимпатичного відділів вегетативної нервової системи.
Ways to Improve the Development of Strength Endurance in Girls and Boys
Authors: Korzh Natalia
Published: July 2021

Topicality. The constant decrease in the level of schoolchildren`s physical qualities and physical health development is the main issue of modern Ukraine. Therefore, the involvement of schoolchildren to the new interesting types of health physical culture and the promotion of exercises is the value task for a contemporary PE teacher at secondary schools. The Purpose of the Research is to substantiate the effectiveness of the implemented Floor Work Methodology for the educational process optimization at PE lessons for senior schoolchildren. The Research Organization. The study involved high school children of main medical group. The proposed methodology increases the motor and overall density of PE. The use of the power part of Floor Work was introduced into each lesson (at the end of the main part of the lesson), regardless of the topic. The Research Results. There was an improvement in the results of both experimental groups (EG): pull up strength-endurance – in 2,7 times (males); flexion and extension of the arms at bent-arm leaning rest – in 1,7 (ma- les) and female – in 2,0 times; raising the legs at a 90-degree angle – in 3,1 (males) and female – in 3,8 times; rope skipping – in 3,2 times (males) and female – in 1,5 times. The highest increase in the results of the static strength endurance development is observed performing the following exercises: hanging bent to an angle – in 2,5 times (males); angled position – in 2,5 times (males) and females – in 3,2 times; half squats with feet shoulder-width apart – in 3,3 times (females). The results of the survey indicate the formation of positive motivation of EG high schoolchildren for PE attendance. Conclusions. Comparison of the results before and after the experiment allowed establishing a positive trend in both EGs with symbolic significance for all indicators of testing, which signifies the effectiveness of the implemented Floor work Methodology into the PE classes.