bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening for Latent Tuberculosis Infection in People Living with HIV: TUBHIVIT Project, a Multicenter Italian Study
Authors: Pipitò Luca , Ricci Elena Delfina , Maggi Paolo , De Socio Giuseppe Vittorio , Pellicano Giovanni Francesco , Trizzino Marcello , Rubino Raffaella , Lanzi Alessandra , Crupi Lorenzo , Capriglione Ilaria , Squillace Nicola , Nunnari Giuseppe , Di Biagio Antonio , Bonfanti Paolo , Cascio Antonio
Published: May 2024

Background: The coexistence of HIV infection and latent tuberculosis infection (LTBI) presents a significant public health concern due to the increased risk of tuberculosis (TB) reactivation and progression to active disease. The multicenter observational cohort study, TUBHIVIT, conducted in Italy from 2017 to 2023, aimed to assess the prevalence of LTBI among people living with HIV (PLHIV) and their outcomes following LTBI screening and therapy initiation. Methods: We performed a prospective study in five referral centers for HIV care in Italy. PLHIV who consented Tto participate underwent QuantiFERON-TB Gold Plus and clinical, microbiological, and radiological assessments to exclude subclinical tuberculosis, as opportune. PLHIV diagnosed with LTBI who started chemoprophylaxis were followed until the end of therapy. Results: A total of 1105 PLHIV were screened for LTBI using the QuantiFERON-TB Gold Plus test, revealing a prevalence of 3.4% of positive results (38/1105). Non-Italy-born individuals exhibited a significantly higher likelihood of testing positive. Thirty-one were diagnosed with LTBI, 1 showed active subclinical TB, and 6 were lost to follow-up before discriminating between latent and active TB. Among the PLHIV diagnosed with LTBI, 83.9% (26/31) started chemoprophylaxis. Most individuals received 6–9 months of isoniazid-based therapy. Of the 26 PLHIV commencing chemoprophylaxis, 18 (69.2%) completed the therapy, while 3 discontinued it and 5 were still on treatment at the time of the analysis. Adverse events were observed in two cases, while in one case the patient refused to continue the treatment.
In Silico and In Vitro Evaluation of the Molecular Mimicry of the SARS-CoV-2 Spike Protein by Common Short Constituent Sequences (cSCSs) in the Human Proteome: Toward Safer Epitope Design for Vaccine Development
Authors: Mizuno Yuya , Nakasone Wataru , Nakamura Morikazu , Otaki Joji M.
Published: May 2024

Spike protein sequences in SARS-CoV-2 have been employed for vaccine epitopes, but many short constituent sequences (SCSs) in the spike protein are present in the human proteome, suggesting that some anti-spike antibodies induced by infection or vaccination may be autoantibodies against human proteins. To evaluate this possibility of “molecular mimicry” in silico and in vitro, we exhaustively identified common SCSs (cSCSs) found both in spike and human proteins bioinformatically. The commonality of SCSs between the two systems seemed to be coincidental, and only some cSCSs were likely to be relevant to potential self-epitopes based on three-dimensional information. Among three antibodies raised against cSCS-containing spike peptides, only the antibody against EPLDVL showed high affinity for the spike protein and reacted with an EPLDVL-containing peptide from the human unc-80 homolog protein. Western blot analysis revealed that this antibody also reacted with several human proteins expressed mainly in the small intestine, ovary, and stomach. Taken together, these results showed that most cSCSs are likely incapable of inducing autoantibodies but that at least EPLDVL functions as a self-epitope, suggesting a serious possibility of infection-induced or vaccine-induced autoantibodies in humans. High-risk cSCSs, including EPLDVL, should be excluded from vaccine epitopes to prevent potential autoimmune disorders.
Wildlife–Livestock Host Community Maintains Simultaneous Epidemiologic Cycles of Mycoplasma conjunctivae in a Mountain Ecosystem
Authors: López-Olvera Jorge Ramón , Ramírez Eva , Martínez-Carrasco Carlos , Granados José Enrique
Published: May 2024

Infectious keratoconjunctivitis (IKC) is an eye disease caused by Mycoplasma conjunctivae that affects domestic and wild caprines, including Iberian ibex (Capra pyrenaica), a medium-sized mountain ungulate. However, its role in IKC dynamics in multi-host communities has been poorly studied. This study assessed M. conjunctivae in Iberian ibex and seasonally sympatric domestic small ruminants in the Natural Space of Sierra Nevada (NSSN), a mountain habitat in southern Spain. From 2015 to 2017, eye swabs were collected from 147 ibexes (46 subadults, 101 adults) and 169 adult domestic small ruminants (101 sheep, 68 goats). Mycoplasma conjunctivae was investigated through real-time qPCR and statistically assessed according to species, sex, age category, year, period, and area. The lppS gene of M. conjunctivae was sequenced and phylogenetically analysed. Mycoplasma conjunctivae was endemic and asymptomatic in the host community of the NSSN. Three genetic clusters were shared by ibex and livestock, and one was identified only in sheep, although each host species could maintain the infection independently. Naïve subadults maintained endemic infection in Iberian ibex, with an epizootic outbreak in 2017 when the infection spread to adults. Wild ungulates are epidemiologically key in maintaining and spreading IKC and other shared diseases among spatially segregated livestock flocks.
Relationship between Milk Yield and Reproductive Parameters on Three Hungarian Dairy Farms
Authors: Amma Zsófia , Reiczigel Jenő , Fébel Hedvig , Solti László
Published: May 2024

It is postulated that there is negative correlation between milk yield and reproductive performance. However, some studies definitely doubt this causality. The aim of our study was to investigate the relationship between milk production and fertility on three dairy farms. The production parameter was the milk yield (in kg), and fertility was expressed by the number of inseminations per conception (AI index), as well as by the length of the service period (in days). A total of 13 012 lactations from cows with their first three lactations completed were analysed. The number of inseminations was significantly correlated with the milk yield and with the studied farm (p < 0.0001), but its correlation with the lactation number was not significant (p = 0.9477). A similar relationship was found after evaluating the length of the service period. A multiplicative model showed that a 2000 kg milk increase extended the service period by 9% and increased the AI index by 13%. Thereafter, using quartiles of the cows, the service period of the highest-producing group rose by 41.5 days, and the AI index by almost 1, compared to the lowest quartile. Our results indicate a definitive decline in reproductive indicators parallel to an increase in milk production but did not prove an inevitable correlation.
Simulation of Sloped-Bed Tuned Liquid Dampers Using a Nonlinear Shallow Water Model
Authors: Khanpour Mahdiyar , Mohammadian Abdolmajid , Shirkhani Hamidreza , Kianoush Reza
Published: May 2024

This research aims to develop an efficient and accurate model for simulating tuned liquid dampers (TLDs) with sloped beds. The model, based on nonlinear shallow water equations, is enhanced by introducing new terms tailored to each specific case. It employs the central upwind method and Minmod limiter functions for flux and interface variable assessment, ensuring both high accuracy and reasonable computational cost. While acceleration, slope, and dissipation are treated as explicit sources, an implicit scheme is utilized for dispersion discretization to enhance the model’s stability, resulting in matrix equations. Time discretization uses the fourth-order Runge–Kutta scheme for precision. The performance of the model has been evaluated using several test cases including dam-breaks on flat and inclined beds and run-up and run-down simulations over parabolic beds, which are relevant to sloshing in tanks with sloped beds. It accurately predicts phenomena such as asymmetric sloshing waves, especially in sloped beds, where pronounced waves occur. Dispersion and dissipation terms are crucial for capturing these effects and maintaining stable wave patterns. An initial perturbation method assesses the tank’s natural period and numerical diffusion. Furthermore, the model integrates with a single-degree-of-freedom (SDOF) system to create a TLD model, demonstrating enhanced damping effects with sloped beds.
Removal of Dyes from Water Using Aluminum-Based Water Treatment Sludge as a Low-Cost Coagulant: Use of Response Surface Methodology
Authors: Benalia Abderrezzaq , Derbal Kerroum , Baatache Ouiem , Lehchili Cheima , Khalfaoui Amel , Pizzi Antonio
Published: May 2024

The aim of this research was to valorize waste (sludge) from a drinking water treatment plant as a coagulant in the removal of dyes (methylene blue and crystal violet) from water and to prevent environmental issues associated with sludge storage. To accomplish this purpose, the response surface methodology based on a central composite design with five levels was implemented. In order to enhance the efficacy of the coagulation–flocculation process, three key operational variables were considered for optimization: the pH, coagulant dosage (mg/L), and initial dye concentration (mg/L). To achieve this, a quadratic polynomial model was established. According to the mathematical model that has been developed, it is predicted that the highest efficiency for removing dyes is 94.44%. This maximum effectiveness is reached when the pH is adjusted to 12.04, the coagulant dose is set at 87.044 mg/L, and the dye concentration of MB is maintained at 2.955 mg/L. Conversely, the best dye removal of CV was attained at 100% under the following conditions: pH = 12.045, a coagulant dosage of 2.955 mg/L, and a dye concentration of 2.955 mg/L. The R2 (98.44% and 95.80% for MB and CV, respectively) validated both models. In this work, the coagulant was characterized by the surface charge, FTIR, BET, and SEM analysis.
Dynamics of outcomes of thoracoscopic microdiscectomy
Authors:   Neurosurgical Outpatient Clinic, Turku University Hospital, Turku, Finlandж AO «European Medical Center», Moscow, Russia, Kivelev Yu. V. , Klimov V. S. ,   AO «European Medical Center», Moscow, Russia; FSAEI HE Peoples» Friendship University of Russia named after Patrice Lumumba, Research Clinical Institute of Pediatrics and Pediatric Surgery named after Academician Yuri Veltischev, FSAEI HE Pirogov Russian National Research Medical University,Moscow, Russia, Gaitan A. S. ,   AO «European Medical Center», Moscow, Russia; FSAEI HE Peoples» Friendship University of Russia named after Patrice Lumumba, Moscow, Russia, Gerald M. ,   FSAEI HE Peoples» Friendship University of Russia named after Patrice Lumumba, Moscow, Russia, Chmutin G. E. ,   FSAEI HE Peoples» Friendship University of Russia named after Patrice Lumumba, Moscow, Russia, Krivoshapkin A. L. ,   AO «European Medical Center», Moscow, Russia; FSAEI HE Peoples» Friendship University of Russia named after Patrice Lumumba, Moscow, Meshalkin National Medical Research Center, Novosibirsk, Russia
Published: May 2024

Object of the study. Thoracoscopic microdiscectomy (TM) is used for surgical treatment of thoracic disc herniations (TDH). The purpose of this study was to analyze the factors influencing the dynamics of outcomes in the early and late postoperative period Materials and methods/ The study had a retrospective, single-center, observational cohort design. The series included all patients without exception who underwent TM from January 2018 to December 2022. Outcomes were assessed according to the Macnab scale adapted for the thoracic spine. Postoperative complications were classified according to the Clavien-Dindo Classification. Statistical univariate analysis of the data was carried out using the Fisher»s method and the Mann-Whitney U test. Multivariate analysis was performed using multiple linear regression with stepwise elimination. Results/ A total of 36 patients were operated on using the TM technique. These included 22 (61 %) women and 14 (39 %) men. The median age was 45±15 years. Early outcomes were assessed 2 months after the patients» surgery. The median duration of long-term outcomes was 22±12 months. The statistical analysis of early outcomes revealed a connection between the localization of a disc herniation in the lower thoracic spine (Th8 — Th12) with simultaneous surgery at two levels and less favorable outcomes. The analysis of long-term outcomes showed that the only prognostic factor was the patient»s condition when assessing the early outcome. Thus, complete recovery was registered at the first control in 13 out of 15 (86 %) patients and at the last control in 13 out of 16 (81 %) patients (p <0.001). Conclusions. The analysis of early and long-term outcomes made it possible to identify factors that determine the dynamics of recovery after thoracoscopic microdiscectomy. The data obtained can be used in planning postoperative management of this group of patients.
Cranioplasty in Chiari malformation surgery
Authors:   Federal State Budgetary Institution «Novosibirsk Research Institute of Traumatology and Orthopedics named after Ya. L. Tsivyan» of the Ministry of Health of the Russian Federation, Novosibirsk, Russia, Mishinov S. V. , Kravets L. Ya. ,   Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia
Published: May 2024

Techniques for surgical correction of Chiari malformation vary significantly. A number of authors report about occipital bone reconstruction at the final surgical stages. The article provides an overview of cranioplasty techniques in surgical interventions for Chiari malformation.
Assessment and analysis of motor dysfunction in idiopathic normal pressure hydrocephalus using computer-assisted stabilometry
Authors:   FSBEI HE Pavlov First St. Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Abytov S. A. , Gavrilov G. V. ,   FSBEI HE Pavlov First St. Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Cherebillo V. Yu. ,   FSBEI HE Pavlov First St. Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Stanishevskiy A. V. ,   FSBMEI HE Military Medical Academy named after S. M. Kirov of the Ministry of Defense of the Russian Federation, St. Petersburg, Skoromets T. A. ,   FSBEI HE Pavlov First St. Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Svistov D. V. ,   FSBMEI HE Military Medical Academy named after S. M. Kirov of the Ministry of Defense of the Russian Federation, St. Petersburg, Burmakina M. Yu. ,   FSBEI HE Pavlov First St. Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg
Published: May 2024

The article presents the results of a study of the assessment and analysis of motor dysfunction in idiopathic normal pressure hydrocephalus using computer-assisted stabilometry. The purpose of this publication is to present the first experience of using computer stabilography in assessing motor function over time in the treatment of patients with idiopathic normal pressure hydrocephalus (iNPH). A non-randomized prospective observational study of the state of balance and gait in patients with iNPH is being conducted on the basis of the Department and Clinic of Neurosurgery of the Pavlov First St. Petersburg State Medical University and the Hospital for War Veterans using the ST-150 computer stabilography system. To date, the study has included 9 patients with a confirmed diagnosis of iNPH who underwent CS at the stages before / after the tap test and after CSF shunt surgery. In all 9 cases, we received a positive result from the operation in the form of improved locomotor function. Computer-assisted stabilometry makes it possible to objectively assess motor function disorders in patients with idiopathic normal pressure hydrocephalus in the preoperative period, optimize diagnostics when selecting patients for surgery and conducting invasive research methods, as well as significantly improve the assessment of the effectiveness of surgical treatment after surgery due to objective quantitative assessment of motor disorders over time.
Prediction of cervicalgia regression after surgery for cervical osteochondrosis
Authors:   FSBI Almazov National Medical Research Center of the Ministry of Health of the Russian Federation, Oleinik E. A. , Oleinik A. A. ,   FSBI Almazov National Medical Research Center of the Ministry of Health of the Russian Federation, Nazarov A. S. ,   FSBI Almazov National Medical Research Center of the Ministry of Health of the Russian Federation, Belyakov Yu. V. ,   FSBI Almazov National Medical Research Center of the Ministry of Health of the Russian Federation, Ivanova N. E. ,   FSBI Almazov National Medical Research Center of the Ministry of Health of the Russian Federation, Voevodkina A. Yu. ,   FSBI Almazov National Medical Research Center of the Ministry of Health of the Russian Federation, Orlov A. Yu. ,   FSBI Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Published: May 2024

In the medical rehabilitation of patients with cervical osteochondrosis, a surgery is one of the stages in the treatment of this spinal pathology. However, the use of modern high-tech diagnostic and treatment methods does not always make it possible to achieve such a result of surgical intervention that would satisfy both the patient and the attending physicians. Due to this, we are obliged to constantly study and develop new diagnostic and therapeutic measures that could help improve the quality of treatment of clinical manifestations of cervical osteochondrosis. The multifactorial analysis of data about patients with cervical osteochondrosis allowed creating a database of various diagnostic and prognostic factors, on the basis of which the «Method for predicting the regression of cervicalgia intensity after surgery for cervical osteochondrosis» was developed depending on the severity of the identified diagnostic and prognostic factors and the volume of the upcoming surgical intervention. The proposed method of predicting the regression of cervicalgia intensity after surgery for cervical osteochondrosis can serve as an integral part of a comprehensive preoperative examination of patients with this spinal pathology. As a result of applying the proposed diagnostic method, additional opportunities arise to guide the surgeon to an individual set of surgical measures with the most promising outcome. Moreover, comfortable psychological conditions are created for the patient as fear and uncertainty in the result of the upcoming treatment are eliminated, which gives him / her confidence in the outcome of the upcoming operation and helps to improve treatment results and reduce the disability of patients. The work is based on the analysis of the results of a comprehensive clinical examination, treatment, and follow-up of 457 patients who underwent surgical treatment for cervical osteochondrosis. The reliability of predicting the regression of cervicalgia intensity after surgery for cervical osteochondrosis is 96.9 %.
A case of acute intestinal obstruction caused by Burkitt’s lymphoma
Authors:   Russian National Research Medical University named after N. I. Pirogov, Kornev L. V.] ,   Moscow city hospital № 24, Moscow, Russia, Yartseva N. D. ,   Russian National Research Medical University named after N. I. Pirogov, Moscow, Russia, Naumov E. K. ,   Russian National Research Medical University named after N. I. Pirogov; Moscow city hospital № 24, Moscow, Russia, Laberco L. A. ,   Russian National Research Medical University named after N. I. Pirogov; Moscow city hospital № 24, Moscow, Russia, Rodoman G. V. ,   Russian National Research Medical University named after N. I. Pirogov; Moscow city hospital № 24, Moscow, Russia, Shakhbazova S. S. ,   Department of General Surgery, Medical Faculty, FSAEI HE N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Published: May 2024

Acute intestinal obstruction is a multifactorial disease. Its causes may be intra-abdominal adhesions, volvulus, bezoar, gallstones, foreign bodies, intestinal tumors, etc. In rare cases, acute intestinal obstruction may be associated with intussusception, which is relatively rare in adults. The purpose of this work is to demonstrate a clinical case of acute small bowel obstruction caused by Burkitt lymphoma. During treatment for a herpetic infection, the patient underwent surgical treatment — ileostomy because of acute intestinal obstruction. In the postoperative period, the patient was hospitalized due to intestinal bleeding; during diagnostic colonoscopy, intussusception of the ileum into the ascending colon was detected; diagnostic laparoscopy, laparotomy, right-sided hemicolectomy with resection of the greater omentum, restoration of intestinal continuity with elimination of the stoma,and formation of an anastomosis were performed. The material obtained intraoperatively was sent for pathomorphological examination, including the method of fluorescent hybridization, which revealed a rearrangement of the 8th chromosome in the region of localization of the MYC gene in tumor cells, and a diagnosis of Burkitt lymphoma was established. The oncological council determined the chemotherapy treatment protocol. According to the literature, Burkitt lymphoma can debut in the cutaneous form, and it is necessary to carry out a differential diagnosis, including chickenpox. There is currently no information about intestinal complications occurring in the cutaneous form of Burkitt lymphoma. It is possible that in the described case, the initially established diagnosis of herpetic infection was incorrect, and Burkitt lymphoma occurred in the cutaneous form.
Gunshot wound of the neck with a fragment localized in close proximity to the initial p art of the esophagus with development of paraesophageal abscess. surgical tactics
Authors:   Federal State-Owned Institution «1469 Naval Clinical Hospital» of the Ministry of Defense of the Russian Federation, Severomorsk, Russia, Anipchenko S. N. , Arkhangelskiy D. A. ,   Federal State-Owned Institution «1469 Naval Clinical Hospital» of the Ministry of Defense of the Russian Federation, Severomorsk, Russia, Kuznetsov S. A. ,   Military Medical Department of the Northern Fleet, Severomorsk, Russia, Zhdanov A. A. ,   Military Medical Department of the Northern Fleet, Severomorsk, Russia, Vysotskiy Ya. V. ,   Federal State-Owned Institution «1469 Naval Clinical Hospital» of the Ministry of Defense of the Russian Federation, Severomorsk, Russia, Bashilov N. I. ,   Federal State-Owned Institution «1469 Naval Clinical Hospital» of the Ministry of Defense of the Russian Federation, Severomorsk, Russia, Allakhverdyan A. S. ,   Federal State Budgetary Educational Institution of Higher Education «Russian University of Medicine» of the Ministry of Health of the Russian Federation, Moscow, Russia, Anipchenko A. N. ,   Federal State Budgetary Educational Institution of Higher Education «Russian University of Medicine» of the Ministry of Health of the Russian Federation, Moscow, Russia
Published: May 2024

One of the features of the special military operation is the prevalence of fragment wounds with predominant damage to unprotected parts of the body. Wounds and injuries to the neck constitute no more than 4 %; however, with these injuries, irreversible losses amount to up to 13 %. The article describes a clinical case of a patient with a blind gunshot fragment wound to the neck, who was admitted to the surgical (thoracic) department of the 1469 Naval Clinical Hospital of the Russian Ministry of Defense 21 days later. The fragment, located behind the pharyngoesophageal junction in the projection of Killian's triangle, led to the development of an abscess and threatened perforation of the esophagus with subsequent development of mediastinitis. In addition, the article on surgical tactics justifies the access and describes in detail the technical methods of surgical inter vention.
METHODOLOGY OF MANAGEMENT OF CULTURAL HERITAGE SITES IN A COMMON DATA ENVIRONMENT
Authors: Savchikov A. , Nakhimovskii A. , Korotkova A.
Published: May 2024

The creation of an information model of a cultural heritage object involves the development of a digital information model, the organization of storage of engineering and technical information and ensuring the collaboration of project participants in a single information space. During this process, all available data about the cultural heritage site is translated into a digital format, which allows effectively managing this information and using it for various purposes. The article considers an approach to creating a common data environment for such objects, taking into account their historical context. Various research methods are used to determine the structure of information storage in the environment of general data on cultural heritage sites. The article summarizes the methods of storing documentation, including the choice of data formats and storage technologies, as well as data management methods such as database organization, distribution of access rights in the System by organizational structure and version control of the information model. The technique was tested on the buildings of St. Petersburg Polytechnic University. It includes various ways of organizing links between a cultural heritage site, its documentation and a digital model. As a result of the analysis, the possibilities of participants in such projects and their role in the preservation of cultural heritage sites were determined.
DYNAMIC OF EXPLOITING INDUSRTIAL OBJECTS AT POST-SOVIET PERIOD
Authors: Shein V.
Published: May 2024

Industrial structures of post-soviet period are urbanizing and do influence on quality of life in anthropogenic environment. Post-soviet period can be considered as crisis for industrial architectural objects in the field of the usage and consequently of the physical condition and obsolescence. There are the patterns have been observed during each time step differently and for all the post-soviet period
Three main time steps of post-soviet period have been revealed. Each one includes special features and paradigmatic dynamics in the question of usage of industrial architectural objects. The first step of devaluation – end of 1980s – beginning of 1990s – the period of the stagnation of industrial activity, partial demolishing of the objects of the industrial architecture. The second step of transition – mid 1990s – 2014 – the period of the chaotic filling of industrial objects, renovation. The third step of renaissance – 2014 – nowadays – the period of the restoration and development of the industries, organization of new industries on the territory of existing industrial structures of soviet period. Nevertheless, with main positive dynamic of usage of that kind of architectural objects, there is no systematic approach to the exploiting of them. This way it is not possible to provide the complexness of industrial and auxiliary processes at the object.
Comportamento do índice tornozelo-braquial e dos parâmetros centrais em um ambulatório de cardiologia
Authors: Barbosa Filho Antônio Carlos de Almeida , Guedes Andressa de Melo Cavalcanti , Tenório Emanuelle Costa Pereira Tavares , Souza Fransciédna de Oliveira , Silva Érica de Andrade Alves da , Paiva Annelise Machado Gomes de
Published: May 2024

Introdução: Os eventos cardiovasculares exibem um crescimento exponencial nas últimas décadas e persistem como a principal causa de mortalidade mundial. O exame do índice tornozelo-braquial (ITB) que auxilia no diagnóstico da doença arterial obstrutiva periférica (DAOP) dos membros inferiores, e os parâmetros centrais (PCs), úteis para o diagnóstico de rigidez arterial, são preditores de eventos cardiovasculares e de mortalidade. Objetivo: Observar o comportamento do índice tornozelo-braquial e dos parâmetros centrais em um ambulatório de Cardiologia em Maceió/Alagoas. Metodologia: Estudo observacional transversal descritivo, realizado com pacientes atendidos em um ambulatório de cardiologia em Maceió/Alagoas. Foram avaliados dados demográficos, clínicos e antropométricos, além da verificação do ITB com o esfigmomanômetro oscilométrico automático. A obtenção dos PCs, como a pressão sistólica central (PSc), velocidade da onda de pulso (VOP) e o Augmentation Index (Alx), foi possível através do equipamento Mobil-O-Graph. Resultados: Foram incluídos 114 pacientes, sendo a maioria do sexo feminino 65,79% (n=75), com média de idade de 54,18 ± 13,67 anos. Cerca de 81,57% (n=93) da amostra apresentou DAOP pelo ITB, mas apenas uma minoria expressou alguma anormalidade em um dos PCs colhidos. A VOP estava alterada em 25,71% (n=27) dos participantes, destes, apenas 7,4% (n=2) possuíam DAOP. Não houve associação entre VOP e DAOP e entre ITB e outros PCs, mesmo após ajuste para sexo. Discussão: Há certa divergência na literatura quanto à associação de PCs, principalmente VOP, com DAOP. Todavia, pode-se dizer que o ITB é um método de baixo custo, fácil acesso e útil no diagnóstico precoce da DAOP, importante para redução da morbimortalidade. Conclusão: As variáveis dos PCs não foram preditivas para o diagnóstico de DAOP e não apresentaram correlação com o ITB, contudo, novos estudos podem elucidar mais seguramente uma possível correlação entre ITB e PCs.
Ensifentrina e a Doença Pulmonar Obstrutiva Crônica (DPOC): uma revisão da eficácia do novo inibidor da fosfodiesterase 3 e 4
Authors: Gordiano Vinícius Ramos , Sampaio Lara de Medeiros , Pinto Guilherme Fernandes Santos , Dourado Júnior Teddy Wilson Araújo , Santos Karine Sarmento , Anjos Ingrid Maria Barbosa dos , Mendes Diego Xavier , Souza Victória Angel Sales de , Marciano Vitória Lima , Freitas Soraya Novaes dos Santos , Monteiro Marcela Meira , Gaudiano Fernanda Lima , Silva Andrew Pereira da
Published: May 2024

A doença pulmonar obstrutiva crônica (DPOC) é uma condição comum e tratável, sendo definida pela limitação progressiva do fluxo aéreo e destruição tecidual, com uma maior prevalência entre pacientes fumantes e pessoas com mais de 40 anos e destacada como a terceira causa mais comum de morbidade e mortalidade entre a população mundial. O presente estudo de revisão buscou avaliar novos estudos acerca da eficácia e segurança da ensifentrina em pacientes com doença pulmonar obstrutiva crônica (DPOC), a partir de ensaios clínicos publicados na literatura médica atual. Trata-se de uma pesquisa de revisão integrativa realizada por meio da base de dados PubMed, que levou em consideração os seguintes critérios de inclusão: ensaios clínicos; artigos publicados nos últimos 05 anos (2019-2024); que possuíam texto completo disponível e que abordassem acerca do uso da ensifentrina em pacientes com DPOC. Ficaram constatadas as melhorias significativas na função pulmonar, redução de exacerbações e melhora dos sintomas em pacientes tratados com ensifentrina. A incidência de efeitos adversos foi semelhante entre os grupos, e os pacientes que receberam ensifentrina relataram melhorias sintomáticas desde o início do tratamento, conforme evidenciado pelos questionários de avaliação. Além disso, a análise dos dados demonstrou uma melhoria gradual e significativa na dispneia ao longo do tratamento, impactando positivamente na qualidade de vida dos pacientes com DPOC. Esses achados sugerem que a ensifentrina pode ser uma opção terapêutica eficaz e segura para um amplo espectro de pacientes com DPOC.
Atendimento de urgência endodôntica associada à dor de origem pulpar: como proceder? - revisão de literatura
Authors: Almeida Yure Moreira de , Oliveira Monalisa Machado Cirilo de , Moura Rafaella Ferreira , Barros Ranna Karine de Oliveira Costa , Lessa Samara Verçosa
Published: May 2024

As buscas por atendimentos de urgências odontológicas constantemente estão relacionadas às urgências endodônticas, dentre elas: pulpite reversível, pulpite irreversível, periodontite apical aguda e abscesso perirradicular. Assim, esse trabalho objetivou analisar e apresentar para a comunidade acadêmica e profissional as principais alterações de origem pulpar, bem como seu manejo clínico. Trata-se de uma revisão de literatura realizada por meio do uso de bases de dados como SciELO e PubMED. Verificou-se que as principais causas das urgências odontológicas são devido às alterações pulpares e do periodonto apical e é importante o conhecimento dos cirurgiões dentistas diante das condutas terapêuticas a serem utilizadas. Pode-se, por fim, considerar que o cirurgião dentista deve estar apto a identificar as alterações pulpares para que a melhor conduta terapêutica possa ser racionalmente implementada evitando o sofrimento e a evolução da infecção no paciente.
Lesões musculoesqueléticas causadas por ausência de ergonomia na odontologia – uma revisão integrativa
Authors: Santos Beatriz Rolim dos , Meireles Aryadne Carvalhedo Souza , Silva Regina Angélica de Araújo Tavares
Published: May 2024

Demonstrar por meio de revisão de artigos a importância da ergonomia e alertar para prevenção de agravos e inatividade da profissão dos cirurgiões-dentistas por doenças ocupacionais. Será realizada uma revisão integrativa de literatura, a qual inclui a análise relevante de pesquisas sobre o assunto, que dão suporte para identificar as principais lesões musculoesqueléticas causadas por ausência de ergonomia por profissionais da odontologia e técnicas de prevenção das devidas lesões, desta forma, será analisado os dados para desenvolver uma explicação mais concreta sobre o assunto abordado. Há relação significativa entre a falta de ergonomia na prática odontológica e o desenvolvimento de lesões musculoesqueléticas em profissionais da odontologia, a falta de ergonomia na prática odontológica está significativamente associada ao aumento da incidência de lesões musculoesqueléticas em profissionais da odontologia. Identificar e descrever os principais distúrbios musculoesqueléticos, avaliar a eficácia de técnicas de prevenção dessas complicações, investigar fatores que afetam a efetividade das técnicas de prevenção, como tempo de trabalho, procedimentos a serem realizados e colaboração dos pacientes.
O efeito da terapia Reiki na dor de pacientes oncológicos: uma revisão sistemática
Authors: Barbieri Carolina Mendes , Lima Bruno Souza de , Ferreira Júlia Corrêa e , Oliveira Aline Rezende de , Silva Yago Nunes Cabral e , Bobbi Robson Martis , Chaves Valéria Ernestânia
Published: May 2024

O Reiki é uma Prática Integrativa e Complementar em Saúde, incluído na Política Nacional de Práticas Integrativas e Complementares e oferecido pelo Sistema Único de Saúde desde 2017. Trata-se de uma terapia de origem japonesa que visa a harmonização do corpo, da mente e do espírito, por meio da canalização da energia universal para o corpo do paciente, pelo terapeuta reikiano. O Reiki é aplicado como tratamento complementar para diversas condições de saúde, dentre elas a dor, que é um dos sintomas mais frequentes em pacientes oncológicos. Estima-se que na metade dos casos a dor é mal controlada, apesar da disponibilidade de tratamentos farmacológicos efetivos. Levando em conta que a dor oncológica é frequente e geradora de grande sofrimento, este trabalho busca investigar as evidências disponíveis sobre a aplicação do Reiki para alívio desse sintoma, a fim de incrementar a validação científica dos seus efeitos. Metodologia: Esta revisão foi elaborada com base na pesquisa de artigos em quatro bases de dados (PubMed, Embase, Scopus e Web of Science), a fim de responder à pergunta “O Reiki é uma prática eficiente para o alívio da dor de pacientes oncológicos?”. 10 artigos foram selecionados, por atenderem aos critérios de elegibilidade. Todos relataram que o Reiki promoveu alívio da dor, sendo que 8 demonstraram resultados estatisticamente significativos. O Reiki auxilia no controle da dor oncológica e na melhoria da qualidade de vida dos pacientes, porém são necessários mais estudos científicos com rigor metodológico para corroborar essa afirmação.
Diagnóstico e atenção farmacêutica em pacientes com diabetes mellitus: uma revisão de literature
Authors: Lima Arthur Aires , Silva Luan Rodrigues da , Oliveira Valéria Maciel Cordeiro de , Ponce Marilis Pereira , Rodrigues Rayssa Soares , Oliveira Talianne Soares de , Fonseca Andressa dos Santos
Published: May 2024

O objetivo é analisar o trabalho do farmacêutico no cenário da diabetes mellitus. Buscou-se descrever as principais ações que esse profissional possui no decorrer da Assistência Farmacêutica com pacientes diagnosticados com diabetes mellitus. Trata-se de uma revisão integrativa da literatura, com base em artigos científicos, teses e dissertações. O recorte temporal dos estudos se deu entre os anos de 2019 a 2023, na base de dados da Scielo, PubMed, LILACs e Google Acadêmico. Nos resultados encontrados, ficou claro que a Atenção Farmacêutica é eficaz no tratamento do diabetes mellitus. Foi observado que os farmacêuticos podem fornecer informações detalhadas sobre o diabetes mellitus, incluindo causas, sintomas, complicações e opções de tratamento. Eles podem ajudar os pacientes a entenderem seus medicamentos, incluindo como tomá-los corretamente, possíveis efeitos colaterais e interações medicamentosas. Eles também podem fornecer orientações sobre o armazenamento adequado dos medicamentos e a importância de não interromper o tratamento sem consultar um profissional de saúde. Conclui-se que a Atenção Farmacêutica desempenha um papel essencial no manejo eficaz do diabetes mellitus, melhorando a adesão ao tratamento, prevenindo complicações, capacitando os pacientes e promovendo melhores resultados de saúde de forma geral.
As alterações celulares e imunológicas e suas implicações no Transtorno de Déficit de Atenção e Hiperatividade (TDAH)
Authors: Barbosa Janaína de Alencar , Sobrinho Caroline Magalhães Tenório Rocha , Feitosa Junior Marcilio Moreira , Figueira João Rubens Ribeiro , Brandão Júlia Tenório , Moura Aline Coelho , Ferreira Brunna Karolyne Aguiar , Borges Isabela Caracas Machado
Published: May 2024

O Transtorno do Déficit de Atenção e Hiperatividade (TDAH) é uma condição neuropsiquiátrica prevalente em crianças, adolescentes e adultos, com impactos significativos em diversos aspectos da vida. Estudos recentes exploram possíveis vínculos entre o sistema imunológico e o TDAH, concentrando-se nas citocinas pró-inflamatórias. O artigo irá abordar as alterações celulares e imunológicas com o TDAH de forma concisa baseada nas interleucinas, no Eixo hipotalâmico-pituitário-adrenal (HPA) e o cortisol, no Eixo intestino-cérebro e a obesidade, finalizando com Neurotrofinas, Estresse oxidativo e Micróglia. Em julho de 2023 foi realizada uma busca na base de dados via PubMed, Lilacs e Scielo, com o uso dos descritores ‘’ADHD’’ and ‘’Inflammatory’’ and “Imunne” e aplicado o filtro dos últimos 8 anos. Foram encontrados 216 artigos e após aplicar os critérios de inclusão e exclusão, 10 foram selecionados para o estudo. Embora as evidências sugiram uma associação potencial entre as interleucinas especialmente a interleucina-6, alguns eixos como o eixo HPA e o eixo intestino-cérebro, além de associar o cortisol, neurotrofinas, estresse oxidativo e células da micróglia com o transtorno abordado, é importante destacar que a problemática em destaque é multifatorial e envolve uma complexa interação de fatores genéticos, ambientais e neurobiológicos.
Análise do tratamento da Glomerulonefrite pós-estreptocócica complicada com encefalopatia hipertensiva na infância
Authors: Silva Livia Regina Gonçalves e , Ferraz Hyale Melo Lima , Mendes Sara Araújo de Medeiros , Brito Ana Gabriela Batista Pinheiro de , Tenório Eduardo Nunes , Carvalho Isabela Tavares de , Mundim Renato Resende
Published: May 2024

A glomerulonefrite pós-estreptocócica (GNPE) é uma doença aguda, manifestando-se até 2 semanas após faringite ou de 3 a 6 semanas após impetigo, com prevalência em crianças entre 6 a 15 anos. Destaca-se a encefalopatia hipertensiva (EH), síndrome neurológica rara em crianças, entre as possíveis complicações. Objetiva-se realizar uma revisão bibliográfica analisando a encefalopatia hipertensiva desencadeada por GNPE, bem como o seu tratamento. Para tanto, procede-se à revisão de literatura com busca no PubMed/MEDLINE e Scielo, utilizando os descritores (“Glomerulonephritis” AND “Hypertensive Encephalopathy”), pesquisados no MeSH e no DeCS. Artigos nacionais e internacionais de revisões sistemáticas e de literatura, publicados nos últimos 10 anos foram selecionados. Manteve-se, após leitura de todos os resumos, 14 artigos, que abordavam a GNPE, a EH e tratamento. Observa-se, então, que a GNPE desencadeia um processo inflamatório nos capilares glomerulares e no mesângio reduzindo a taxa de filtração glomerular, bem como sua capacidade de controle, provocando insuficiência renal aguda que cursa com hipervolemia, edema e hipertensão arterial, presente em cerca de 60 a 80% dos casos. A hipertensão arterial somada à ineficiência da autorregulação cerebral do fluxo sanguíneo, provoca lesões aguda, estabelecendo, assim, a EH em 7,9% dos pacientes. A EH tem caráter progressivo e reversível, quando prontamente tratada, sendo classificada como uma emergência médica, visando reverter e conter o avanço dos danos cerebrais deflagrados. Seus sinais e sintomas variam de leves a graves e estão diretamente relacionados ao edema cerebral - cefaleia (85%), vômitos, confusões mentais, convulsões, letargia e alterações visuais e retinianas (30%).
Coronectomia: uma abordagem alternativa para prevenir lesões no nervo alveolar inferior durante a extração de terceiros molares inferiores
Authors: Santos Neto João Alves dos , Barros Breno Augusto Arrial , Silva Junior Geraldo Prisco da , Santos Kelveys Abraão Alves dos , Moita Daniela Neres , Malaquias Vitória , Botelho Nathália Maria de Sousa , Oliveira Marlucia Anjos
Published: May 2024

A extração de terceiros molares inferiores é um procedimento comum na odontologia, porém pode estar associada a complicações, sendo a lesão do nervo alveolar inferior (NAI) a mais preocupante. A coronectomia é uma técnica recomendada para cirurgias de terceiros molares inferiores próximos ou em contato com o NAI, com o objetivo de reduzir o risco de lesões ao nervo. No entanto, a decisão de realizar ou não essa abordagem cirúrgica pode ser complexa e envolver vários fatores clínicos. O objetivo deste estudo era analisar a eficácia da coronectomia na redução de lesões do NAI causadas por terceiros molares inferiores em íntimo contato ou próximos ao nervo, bem como as complicações cirúrgicas. Foram incluídos como critério de inclusão os artigos publicados em português, inglês e/ou espanhol, que abordassem a temática de interesse e estivessem publicados e indexados nos respectivos bancos de dados National Library of Medicine (PubMed), Biblioteca Virtual em Saúde (BVS) e Google Acadêmico, com data de publicação entre 2013 e 2023. A coronectomia tem se mostrado eficaz na redução de lesões no NAI em cirurgias de terceiros molares inferiores próximos ou em contato direto com o NAI. Portanto, a prevenção de lesões do NAI em cirurgias desses molares pode ser alcançada por meio da coronectomia, desde que seja realizada de forma competente e o paciente tenha uma boa indicação para a técnica.
Perspectivas de implantação do TBC no assentamento padre Nestor/ se, sob a ótica dos assentados
Authors: Nascimento Irinéia Rosa do , Santos Carmem Lúcia , Melo Mailay Mota de , Andrade Geislane Santos
Published: May 2024

A agricultura familiar busca estratégias de reprodução socioeconômica e cultural, frente a um modelo de desenvolvimento rural que contribui para a desagregação social destas populações. Objetivou-se com o presente trabalho estudar, de forma participativa, a dinâmica do assentamento Padre Nestor, identificando as potencialidades e limitações, diante da perspectiva de implantação de atividades de Turismo de Base Comunitária. Foram utilizadas ferramentas de Diagnóstico Rápido Participativo na caracterização das atividades desenvolvidas nos diferentes espaços do assentamento. O Padre Nestor apresenta atrativos para o turismo e uma organização social típica dos projetos da reforma agrária. Esses fatos motivam a implantação TBC, já que a organização da comunidade reflete nas buscas de parceiros externos e garante a representatividade das lideranças em comitês de desenvolvimento nas diferentes esferas do poder público, para reivindicar as ações estruturais necessárias.
The importance of innovative technologies in creating sustainable agriculture in the European Union
Authors: Lorek Elżbieta , Lorek Agnieszka , Michaliszyn-Gabryś Beata
Published: May 2024

The article aims to evaluate – from the point of view of selected socio-economic aspects – the implementation of an innovative weed control technology into agricultural practice using laser energy targeted at reducing pesticide use. The achievement of the stated objective required an analysis of the research output concerning the problem of pesticide sustainability in European Union agriculture and an analysis of EU policies in this field. The paper also utilises data obtained through research by conducting in-depth interviews with representatives of three stakeholder groups: farmers, society and business. The subject of the interviews was to assess the impact of large-scale dissemination of an innovative weed control technology on selected socio-economic aspects. The article is one of the first studies to assess the social impact of innovative technologies using artificial intelligence and laser technology for weed control in agriculture. The implementation of this technology can have a significant impact on running farms in a more sustainable way, but a prerequisite for its successful use is the inclusion of social and economic considerations.
Forgery of signatures by means of a mechanicaldigital device. Assumptions of the Rękopis (Manuscript) Project
Authors:   Centralne Laboratorium Kryminalistyczne Policji, Kocielnik Łukasz
Published: May 2024

The issue of forgery using mechanical-digital devices is increasingly appearing in forensic studies. Research conducted by experts on the subject has so far not allowed categorical conclusions on the genesis of a given writing sample. In Poland and around the world, no method has been developed to identify signatures made using various types of mechanical-digital devices. To address concerns and questions, the Central Forensic Laboratory of the Police together with the consortium partners, i.e. The Polish Society of Forensic Science and JAS technologies Ltd. started a research project in 2021 entitled Intelligent System for Identification of Forgery of Biometric Handwriting Features, operating under the code name Manuscript. The project is in the implementation phase, so this article contains the main ideas of the project. However, the publication began with an introduction to the issue of signature forgery, focusing on a description of its various types. At the same time, the possibilities for the use of mechanical-digital devices reproducing signatures in the United States are introduced, and previous attempts to study mechanically produced manuscripts are described.
Effect of the dulling of headlight covers and type of bulbs on the dipped beam light spot range for a Toyota Corolla
Authors:   Forensic Laboratory of the Voivodeship Police Headquarters in Kielce, Noga Bartłomiej
Published: May 2024

The article presents the results of a study aimed at demonstrating the relationship between the technical condition of headlight covers (in-service and brand-new) and the type of light source used (in-service and new bulbs), and the range of the light spot of a Toyota Corolla passenger car.