bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legends from miR-6883 Family miRNAs Target CDK4/6 to Induce G1 Phase Cell-Cycle Arrest in Colon Cancer Cells
Authors: Lulla Amriti R. , Slifker Michael J. , Zhou Yan , Lev Avital , Einarson Margret B. , Dicker David T. , El-Deiry Wafik S.
Published: April 2023

Supplementary Fig. 1. Expression of CDK4, CDK6, and PER1. Supplementary Fig. 2. Sequence similarity of miRNA family and p16 status CRC cell lines. Supplementary Fig. 3. Efficacy in miRNA mimics in melanoma cell lines. Supplementary Fig. 4. Combination of palbociclib and irinotecan. Supplementary Fig. 5. Combination of CDK4 siRNA and irinotecan. Supplementary Table S1. List of primers. Supplementary Table S2. CDK4 TargetScan analysis. Supplementary Table S3. CDK6 TargetScan analysis.
Figure S1 from Restoration of Natural Killer Cell Antimetastatic Activity by IL12 and Checkpoint Blockade
Authors: Ohs Isabel , Ducimetière Laura , Marinho Joana , Kulig Paulina , Becher Burkhard , Tugues Sonia
Published: April 2023

Effects of NK cell, CD4 T cells and gd T cell ablation on pulmonary metastases and IFN-γ production by lung NK cells
Figure S2 from Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma
Authors: Sadahiro Hirokazu , Kang Kyung-Don , Gibson Justin T. , Minata Mutsuko , Yu Hai , Shi Junfeng , Chhipa Rishi , Chen Zhihong , Lu Songjian , Simoni Yannick , Furuta Takuya , Sabit Hemragul , Zhang Suojun , Bastola Soniya , Yamaguchi Shinobu , Alsheikh Hebaallah , Komarova Svetlana , Wang Jun , Kim Sung-Hak , Hambardzumyan Dolores , Lu Xinghua , Newell Evan W. , DasGupta Biplab , Nakada Mitsutoshi , Lee L. James , Nabors Burt , Norian Lyse A. , Nakano Ichiro
Published: April 2023

Supplementary Figure S2. CD11b(+) cells were depleted by BLZ945.
Figure S1 from Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma
Authors: Sadahiro Hirokazu , Kang Kyung-Don , Gibson Justin T. , Minata Mutsuko , Yu Hai , Shi Junfeng , Chhipa Rishi , Chen Zhihong , Lu Songjian , Simoni Yannick , Furuta Takuya , Sabit Hemragul , Zhang Suojun , Bastola Soniya , Yamaguchi Shinobu , Alsheikh Hebaallah , Komarova Svetlana , Wang Jun , Kim Sung-Hak , Hambardzumyan Dolores , Lu Xinghua , Newell Evan W. , DasGupta Biplab , Nakada Mitsutoshi , Lee L. James , Nabors Burt , Norian Lyse A. , Nakano Ichiro
Published: April 2023

Supplementary Figure S1. AXL expression has inverse correlation with PDGFRα expression in GSCs.
Tables S4 from Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis
Authors: Hsiao Kuei-Yang , Lin Ya-Chi , Gupta Sachin Kumar , Chang Ning , Yen Laising , Sun H. Sunny , Tsai Shaw-Jenq
Published: April 2023

The list of circRNAs identified in colorectal cancer
Supplemental Figure S2 from PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1
Authors: Lacey Alexandra , Rodrigues-Hoffman Aline , Safe Stephen
Published: April 2023

Role of Sp1, p300 and CBP in PAX3-FOXO1A expression. ARMS cells were transfected with siSp1 (A), sip300 (B) and siCBP (C) for 72 hr, and whole cell lysates were analyzed by western blots.
Table S5 from Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis
Authors: Hsiao Kuei-Yang , Lin Ya-Chi , Gupta Sachin Kumar , Chang Ning , Yen Laising , Sun H. Sunny , Tsai Shaw-Jenq
Published: April 2023

The list of miRNAs targeting exons 8 to 10 of CCDC66
Supplementary Table 3 from New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Authors: Wilson Leah J. , Linley Adam , Hammond Dean E. , Hood Fiona E. , Coulson Judy M. , MacEwan David J. , Ross Sarah J. , Slupsky Joseph R. , Smith Paul D. , Eyers Patrick A. , Prior Ian A.
Published: April 2023

Human phospho-site census and kinase substrate consensus motifs.
Supplemental Tables 1 and 2 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Authors: Bakst Richard L. , Xiong Huizhong , Chen Chun-Hao , Deborde Sylvie , Lyubchik Anna , Zhou Yi , He Shizhi , McNamara William , Lee Sei-Young , Olson Oakley C. , Leiner Ingrid M. , Marcadis Andrea R. , Keith James W. , Al-Ahmadie Hikmat A. , Katabi Nora , Gil Ziv , Vakiani Efsevia , Joyce Johanna A. , Pamer Eric , Wong Richard J.
Published: April 2023

Tables contain information on the list of candidate genes screened from murine macrophages and clinical data on human pancreatic samples. This file contains 2 tables (Supplemental Tables 1 and 2).
Supplementary Table 1 from New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Authors: Wilson Leah J. , Linley Adam , Hammond Dean E. , Hood Fiona E. , Coulson Judy M. , MacEwan David J. , Ross Sarah J. , Slupsky Joseph R. , Smith Paul D. , Eyers Patrick A. , Prior Ian A.
Published: April 2023

The human protein kinome
Supplementary File 1 from New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Authors: Wilson Leah J. , Linley Adam , Hammond Dean E. , Hood Fiona E. , Coulson Judy M. , MacEwan David J. , Ross Sarah J. , Slupsky Joseph R. , Smith Paul D. , Eyers Patrick A. , Prior Ian A.
Published: April 2023

Phospho-proteome profiler.
Figs S2-S5 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Authors: Bakst Richard L. , Xiong Huizhong , Chen Chun-Hao , Deborde Sylvie , Lyubchik Anna , Zhou Yi , He Shizhi , McNamara William , Lee Sei-Young , Olson Oakley C. , Leiner Ingrid M. , Marcadis Andrea R. , Keith James W. , Al-Ahmadie Hikmat A. , Katabi Nora , Gil Ziv , Vakiani Efsevia , Joyce Johanna A. , Pamer Eric , Wong Richard J.
Published: April 2023

CCL2 and CCR2 loss results in impaired PNI and IM recruitment following cancer injection independent of tumor growth. This file contains 4 supplemental figures (S2-S5), which demonstrate the importance of both CCR2 and CCL2 in IM recruitment.
Figs S12-S13 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Authors: Bakst Richard L. , Xiong Huizhong , Chen Chun-Hao , Deborde Sylvie , Lyubchik Anna , Zhou Yi , He Shizhi , McNamara William , Lee Sei-Young , Olson Oakley C. , Leiner Ingrid M. , Marcadis Andrea R. , Keith James W. , Al-Ahmadie Hikmat A. , Katabi Nora , Gil Ziv , Vakiani Efsevia , Joyce Johanna A. , Pamer Eric , Wong Richard J.
Published: April 2023

Clinical outcomes in human PDA as a function of macropahge infiltration and CTSB expression. This file contains two supplemental figures (S12-S13).
Supplementary Table S1 from Genetic Manipulation of Helicobacter pylori Virulence Function by Host Carcinogenic Phenotypes
Authors: Suarez Giovanni , Romero-Gallo Judith , Sierra Johanna C. , Piazuelo M. Blanca , Krishna Uma S. , Gomez Martin A. , Wilson Keith T. , Peek Richard M.
Published: April 2023

PCR and sequencing primer sequences
Supplementary Tables-3-4 from The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells
Authors: Jinesh Goodwin G. , Kamat Ashish M.
Published: April 2023

Supplementary tables showing the Associations between defects in programmed cell death and hepatosplenomegaly/splenomegaly in vivo; and Cancer or cancer therapeutic associated hematuria
Supplementary figures from Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition
Authors: Yaeger Rona , Yao Zhan , Hyman David M. , Hechtman Jaclyn F. , Vakiani Efsevia , Zhao HuiYong , Su Wenjing , Wang Lu , Joelson Andrew , Cercek Andrea , Baselga Jose , de Stanchina Elisa , Saltz Leonard , Berger Michael F. , Solit David B. , Rosen Neal
Published: April 2023

Supplementary Figures 1-5: Supplementary Figure 1 - validation and characterization of acquired genomic alterations, Supplementary Figure 2 - RAS amplification leads to increased RAS-GTP and dimerization of RAF, Supplementary Figure 3 - Increase in NRAS expression is sufficient to cause resistance to RAF/EGFR inhibition in vitro in CRC, Supplementary Figure 4 - Increase in NRAS expression does not cause resistance to RAF inhibition in melanoma, Supplementary Figure 5 - Combined EGFR and RAF dimer inhibitors lead to better inhibition of signaling and tumor growth than RAF dimer inhibitor alone in BRAF V600E CRC.
Supplementary Table-1 from The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells
Authors: Jinesh Goodwin G. , Kamat Ashish M.
Published: April 2023

Blebbishield-mediated transformation-specific microarray gene expression signature
Supplemental material from Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer
Authors: Rho Jin Kyung , Lee In Yong , Choi Yun Jung , Choi Chang-Min , Hur Jae-Young , Koh Jong Sung , Lee Jaekyoo , Suh Byung-Chul , Song Ho-Juhn , Salgaonkar Paresh , Lee Jungmi , Lee Jaesang , Jung Dong Sik , Kim Sang-Yeob , Woo Dong-Cheol , Baek In-Jeoung , Lee Joo-Yong , Ha Chang Hoon , Sung Young Hoon , Kim Jeong Kon , Kim Woo Sung , Song Joon Seon , Kim Cheol Hyeon , Bivona Trever G. , Lee Jae Cheol
Published: April 2023

This file contains Supplemental figures, tables, and legends that accompany the main figures, as indicated in each legend. There are 3 supplemental tables and 6 supplemental figures. Table S1. List of potential target of the GNS compounds that were profiled in Figure 1 of the main text. Table S2. Half-maximal inhibitor concentration of the EGFR inhibitors tested. Table S3. Blood-brain-barrier penetration of the GNS compounds as assessed by the indicated pharmacokinetic measurements. Figure S1. Structural modeling studies show the binding characteristics of the indicated EGFR inhibitors. Figure S2. The effects of each EGFR inhibitor in the cell lines expressing mutant or wild type EGFR. Figure S3. In vivo effects of the GNS compounds. Figure S4. In vivo anti-tumor effects of the GNS compounds. Figure S5. In vivo anti-tumor effects of the GNS compounds in intracranial EGFR-mutant lung cancer. Figure S6. In vivo anti-tumor effects of the indicated EGFR inhibitors in intracranial EGFR-mutant lung cancer.
Supplementary Figure S3. c-ABL Inhibits PLK1 Degradation through Ubiquitin- Proteasome Pathway. from Cervical Cancer Growth Is Regulated by a c-ABL–PLK1 Signaling Axis
Authors: Yang Xu , Chen Gang , Li Wei , Peng Changmin , Zhu Yue , Yang Xiaoming , Li Teng , Cao Cheng , Pei Huadong
Published: April 2023

A-B, HeLa cells were infected with lentivirus expressing HA-c-ABL or shRNAs targeted to c-ABL. Cell lysates were analysed two days post-infection by immunoblotting. The mRNA levels of PLK1 were evaluated by qPCR ({plus minus} s.e.m., n=3). C, HeLa cells were treated with imatinib (10 μM) for indicated times, then PLK1 protein and mRNA levels were analyzed ({plus minus} s.e.m., n=3). D-F, HEK293 trasfected with indicated plasmids, the cells were incubated with 100 μg/mL CHX for indicated times.
Supplementary Table 1 from Interplay between Immune Checkpoint Proteins and Cellular Metabolism
Authors: Lim Sangbin , Phillips Joshua B. , Madeira da Silva Luciana , Zhou Ming , Fodstad Oystein , Owen Laurie B. , Tan Ming
Published: April 2023

Supplementary Table 1
Table S4 from Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer
Authors: Cejalvo Juan M. , Martínez de Dueñas Eduardo , Galván Patricia , García-Recio Susana , Burgués Gasión Octavio , Paré Laia , Antolín Silvia , Martinello Rosella , Blancas Isabel , Adamo Barbara , Guerrero-Zotano Ángel , Muñoz Montserrat , Nucíforo Paolo , Vidal María , Pérez Ramón M. , Chacón López-Muniz José I. , Caballero Rosalía , Peg Vicente , Carrasco Eva , Rojo Federico , Perou Charles M. , Cortés Javier , Adamo Vincenzo , Albanell Joan , Gomis Roger R. , Lluch Ana , Prat Aleix
Published: April 2023

Table
Table S2 from Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer
Authors: Cejalvo Juan M. , Martínez de Dueñas Eduardo , Galván Patricia , García-Recio Susana , Burgués Gasión Octavio , Paré Laia , Antolín Silvia , Martinello Rosella , Blancas Isabel , Adamo Barbara , Guerrero-Zotano Ángel , Muñoz Montserrat , Nucíforo Paolo , Vidal María , Pérez Ramón M. , Chacón López-Muniz José I. , Caballero Rosalía , Peg Vicente , Carrasco Eva , Rojo Federico , Perou Charles M. , Cortés Javier , Adamo Vincenzo , Albanell Joan , Gomis Roger R. , Lluch Ana , Prat Aleix
Published: April 2023

Table
Table S1 from Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer
Authors: Cejalvo Juan M. , Martínez de Dueñas Eduardo , Galván Patricia , García-Recio Susana , Burgués Gasión Octavio , Paré Laia , Antolín Silvia , Martinello Rosella , Blancas Isabel , Adamo Barbara , Guerrero-Zotano Ángel , Muñoz Montserrat , Nucíforo Paolo , Vidal María , Pérez Ramón M. , Chacón López-Muniz José I. , Caballero Rosalía , Peg Vicente , Carrasco Eva , Rojo Federico , Perou Charles M. , Cortés Javier , Adamo Vincenzo , Albanell Joan , Gomis Roger R. , Lluch Ana , Prat Aleix
Published: April 2023

Table
Figure S3 from Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer
Authors: Cejalvo Juan M. , Martínez de Dueñas Eduardo , Galván Patricia , García-Recio Susana , Burgués Gasión Octavio , Paré Laia , Antolín Silvia , Martinello Rosella , Blancas Isabel , Adamo Barbara , Guerrero-Zotano Ángel , Muñoz Montserrat , Nucíforo Paolo , Vidal María , Pérez Ramón M. , Chacón López-Muniz José I. , Caballero Rosalía , Peg Vicente , Carrasco Eva , Rojo Federico , Perou Charles M. , Cortés Javier , Adamo Vincenzo , Albanell Joan , Gomis Roger R. , Lluch Ana , Prat Aleix
Published: April 2023

Figure
Supplementary Figure S4 from Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve–Dependent Regulation of NKG2D and CCR5
Authors: Song Yanfang , Gan Yu , Wang Qing , Meng Zihong , Li Guohua , Shen Yuling , Wu Yufeng , Li Peiying , Yao Ming , Gu Jianren , Tu Hong
Published: April 2023

EE prevents experimental lung metastases of murine melanoma cells.
Supplemental Figures and Tables from EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression
Authors: Chen Xueran , Ma Huihui , Wang Zhen , Zhang Shangrong , Yang Haoran , Fang Zhiyou
Published: April 2023

This file contains 9 supplemental figures and 3 supplemental tables. Supplemental Figure 1. There are four potential binding sites (red) for NF-Y in the 1kb upstream region of the ZDHHC5 promoter. Supplemental Figure 2. The mutant p53 and NF-Y co-recruit onto the ZDHHC5 promoter. Supplemental Figure 3. Genetic, differentiated and proliferative characteristics of CA-KRAS/hTERT/DN-p53/ZDHHC5 hNSCs. Supplemental Figure 4. There is co-expression of ZDHHC5 and SOX2 or CD133 in p53 mutant glioma samples and glioma stem cells. Supplemental Figure 5. ZDHHC5 regulates self-renewal of p53 mutant GSCs. Supplemental Figure 6. ZDHHC5 regulates tumor angiogenesis in xenografted brain tumors from p53 mutant GSCs. Supplemental Figure 7. ZDHHC5 specifically regulates EZH2 palmitoyaltion level and EZH2-mediated colony formation and cell migartion. Supplemental Figure 8. The EZH2 potential palmitoyaltion sites which are conserved in different species. Supplemental Figure 9. ZDHHC5 regulates EZH2-mediated glioma development. Supplemental Table1. p53 mutational status in glioma. Supplemental Table2. The Relationship between ZDHHC5 expression and p53 mutantional status in glioma. Supplemental Table 3. Limiting dilution tumor formation of p53 mutant GSCs transfected with or without ZDHHC5 shRNA.
Suppelmentary Figure S5 from Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve–Dependent Regulation of NKG2D and CCR5
Authors: Song Yanfang , Gan Yu , Wang Qing , Meng Zihong , Li Guohua , Shen Yuling , Wu Yufeng , Li Peiying , Yao Ming , Gu Jianren , Tu Hong
Published: April 2023

EE increases the expression levels of INF-gamma and granzyme B in NK cells.
Supplementary Video S2 from Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion
Authors: Ohishi Tomokazu , Yoshida Haruka , Katori Masamichi , Migita Toshiro , Muramatsu Yukiko , Miyake Mao , Ishikawa Yuichi , Saiura Akio , Iemura Shun-ichiro , Natsume Tohru , Seimiya Hiroyuki
Published: April 2023

Time-lapse imaging of HTC75 cells transfected with TNKS1BP1 siRNA.
Supplemental Figure 3 from Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer
Authors: Thomas Jeffrey D. , Longen Charles G. , Oyer Halley M. , Chen Nan , Maher Christina M. , Salvino Joseph M. , Kania Blase , Anderson Kelsey N. , Ostrander William F. , Knudsen Karen E. , Kim Felix J.
Published: April 2023

RNAi mediated knockdown of ATG5 does not prevent IPAG induced decrease in AR levels.
Supplementary Table 1. DDR proficiency of PDA cells affects PARPi response from Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Authors: Chand Saswati N. , Zarei Mahsa , Schiewer Matthew J. , Kamath Akshay R. , Romeo Carmella , Lal Shruti , Cozzitorto Joseph A. , Nevler Avinoam , Scolaro Laura , Londin Eric , Jiang Wei , Meisner-Kober Nicole , Pishvaian Michael J. , Knudsen Karen E. , Yeo Charles J. , Pascal John M. , Winter Jordan M. , Brody Jonathan R.
Published: April 2023

This table indicates that cells lacking intact DDR machinery i.e. BRCA2 deficient Capan-1 and FA-deficient Hs 766t and PL11 are more sensitive to PARPi.
Supplementary Figure S6. PARG overexpression rescues HuR's regulation of PARPi response from Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Authors: Chand Saswati N. , Zarei Mahsa , Schiewer Matthew J. , Kamath Akshay R. , Romeo Carmella , Lal Shruti , Cozzitorto Joseph A. , Nevler Avinoam , Scolaro Laura , Londin Eric , Jiang Wei , Meisner-Kober Nicole , Pishvaian Michael J. , Knudsen Karen E. , Yeo Charles J. , Pascal John M. , Winter Jordan M. , Brody Jonathan R.
Published: April 2023

PARG rescue in HuR silenced cells restores PARPi resistance. Small-molecule inhibition of HuR prevents its cytoplasmic accumulation, abrogates PARG mRNA regulation and increases PARPi sensitivity, independent of DDR status.
Supplementary Figure S5. HuR and PARG inhibition enhance PARPi-mediated accumulation of apoptosis and DNA damage from Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Authors: Chand Saswati N. , Zarei Mahsa , Schiewer Matthew J. , Kamath Akshay R. , Romeo Carmella , Lal Shruti , Cozzitorto Joseph A. , Nevler Avinoam , Scolaro Laura , Londin Eric , Jiang Wei , Meisner-Kober Nicole , Pishvaian Michael J. , Knudsen Karen E. , Yeo Charles J. , Pascal John M. , Winter Jordan M. , Brody Jonathan R.
Published: April 2023

PARPi treatment mediated apoptosis and chromatin- associated trapping of PARP1 is significantly enhanced upon HuR and PARG inhibition.
Supplementary Figure S3. HuR regulates PARG mRNA expression from Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Authors: Chand Saswati N. , Zarei Mahsa , Schiewer Matthew J. , Kamath Akshay R. , Romeo Carmella , Lal Shruti , Cozzitorto Joseph A. , Nevler Avinoam , Scolaro Laura , Londin Eric , Jiang Wei , Meisner-Kober Nicole , Pishvaian Michael J. , Knudsen Karen E. , Yeo Charles J. , Pascal John M. , Winter Jordan M. , Brody Jonathan R.
Published: April 2023

HuR regulates all isoforms of PARG by binding a discrete minimal binding region (MBR) within its 3'UTR in both DDR- proficient MIA PaCa-2 and DDR- deficient Hs 766t cells. Such PARG mRNA and protein expression is also increased with other non-PARPi stress such as gemcitabine and oxaliplatin treatment, which simultaneously induce HuR cytoplasmic translocation.
Supplementary Figure S6 from FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4–GSK3β–Nrf2 Signaling
Authors: Teng Yong , Zhao Huakan , Gao Lixia , Zhang Wenfa , Shull Austin Y. , Shay Chloe
Published: April 2023

Supplementary Figure S6. FGF19 overexpressing MHCC97L cells (FGF19 O/E) and the control cells (EV) were transfected with siRNA targeted against luciferase (siNC) or Nrf2 (siNrf2), and cell viability was determined by MTS assays at different time points. *P<0.05, **P<0.01.
Supplementary Table 4 from ATR Is a Therapeutic Target in Synovial Sarcoma
Authors: Jones Samuel E. , Fleuren Emmy D.G. , Frankum Jessica , Konde Asha , Williamson Chris T. , Krastev Dragomir B. , Pemberton Helen N. , Campbell James , Gulati Aditi , Elliott Richard , Menon Malini , Selfe Joanna L. , Brough Rachel , Pettitt Stephen J. , Niedzwiedz Wojciech , van der Graaf Winette T.A. , Shipley Janet , Ashworth Alan , Lord Christopher J.
Published: April 2023

This file lists Z-score data of the synovial sarcoma (SS) specific hits from the siRNA screen. SS genetic dependencies were identified by comparing the siRNA Z-scores from the SS tumour cell line screens to siRNA Z-score profiles of >130 other tumour cell lines, and genes are ranked according to median difference between the SS tumour cell lines and other tumour cell lines.
Supplementary Table 1 from ATR Is a Therapeutic Target in Synovial Sarcoma
Authors: Jones Samuel E. , Fleuren Emmy D.G. , Frankum Jessica , Konde Asha , Williamson Chris T. , Krastev Dragomir B. , Pemberton Helen N. , Campbell James , Gulati Aditi , Elliott Richard , Menon Malini , Selfe Joanna L. , Brough Rachel , Pettitt Stephen J. , Niedzwiedz Wojciech , van der Graaf Winette T.A. , Shipley Janet , Ashworth Alan , Lord Christopher J.
Published: April 2023

This file contains the complete list of Dharmacon SMARTpool 384 well plate-arrayed siRNA libraries used in this paper. It is designed to target 714 kinases and kinase-related genes, 320 Wnt-pathway associated genes, 80 tumour suppressor genes, and 480 genes recurrently altered in human cancers.
Supplementary Materials and Methods from OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues
Authors: Drenberg Christina D. , Gibson Alice A. , Pounds Stanley B. , Shi Lei , Rhinehart Dena P. , Li Lie , Hu Shuiying , Du Guoqing , Nies Anne T. , Schwab Matthias , Pabla Navjotsingh , Blum William , Gruber Tanja A. , Baker Sharyn D. , Sparreboom Alex
Published: April 2023

This file contains supplementary information regarding materials and methods including: chemicals and reagents, early drug uptake, NCI60 correlation analysis, quantitative determination of ergothioneine, and culturing keratinocytes.
Combined Supplementary Information from Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer
Authors: Goldstein Jonathan T. , Berger Ashton C. , Shih Juliann , Duke Fujiko F. , Furst Laura , Kwiatkowski David J. , Cherniack Andrew D. , Meyerson Matthew , Strathdee Craig A.
Published: April 2023

Supplementary Methods. Supplementary Figure 1. Somatic alterations in PPARG and RXRA are hallmarks of luminal bladder cancer. Supplementary Figure 2. PPARG pathway is activated by overexpression of RXRA S427F/S427Y, but not other mutant alleles in bladder cancer cells. Supplementary Figure 3. Representation of the effects of ligand-dependent modulation on the PPARG interactome. Supplementary Figure 4. Downregulation of FABP4 protein by treatment of PPARG-activated bladder cancer cell lines by inverse-agonist T0070907. Supplementary Figure 5. Genome engineering scheme for generating reporter cell line. Supplementary Figure 6. Basal expression of FABP4 is reduced by PPARG inverse agonists, but not antagonists. Supplementary Figure 7. Lipid metabolism genes are inhibited by PPARG inverse-agonists. Supplementary Figure 8. PPARG inverse-agonists inhibit proliferation of PPARG activated bladder cancer cell lines in clonogenic assays. Supplementary Figure 9. PPARG inverse-agonists, but not antagonists, inhibit proliferation of PPARG-activated bladder cancer cell lines. Supplementary Figure 10. Somatic alterations in RXRA and PPARG.
Supplemental data from An Essential Role of Maspin in Embryogenesis and Tumor Suppression
Authors: Dzinic Sijana H. , Bernardo M. Margarida , Li Xiaohua , Fernandez-Valdivia Rodrigo , Ho Ye-Shih , Mi Qing-Sheng , Bandyopadhyay Sudeshna , Lonardo Fulvio , Vranic Semir , Oliveira Daniel S.M. , Bonfil R. Daniel , Dyson Gregory , Chen Kang , Omerovic Almasa , Sheng Xiujie , Han Xiang , Wu Dinghong , Bi Xinling , Cabaravdic Dzenana , Jakupovic Una , Wahba Marian , Pang Aaron , Harajli Deanna , Sakr Wael A. , Sheng Shijie
Published: April 2023

List of supplemental materials accompanying the current manuscript: 1. Table S1. List of primers and expected amplicon sizes for genotyping and mRNA detection. 2. Table S2. Live births & gender distribution. 3. Figure S1. Tertiary maspin structure. 4. Figure S2. qRT-PCR detection of mRNA in mouse mammary gland and small intestine tissues using primers PB1687/1688. 5. Figure S3. Identification of PrPC mRNA. 6. Figure S4. Histopathological (H&E) and immunohistological (IHC) analysis of mouse tissues. 7. Figure S5. Mouse growth analysis. 8. Figure S6. Histopathological analysis of mouse testes and ovaries. 9. Figure S7. Mammary gland adenoma of mouse KO tissue. 10. Figure S8. Histomorphometry of wt/wt mouse prostate. 11. Figure S9. Histopathological analysis of mouse small intestine tissues.
Figure S1 from Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates
Authors: Caculitan Niña G. , dela Cruz Chuh Josefa , Ma Yong , Zhang Donglu , Kozak Katherine R. , Liu Yichin , Pillow Thomas H. , Sadowsky Jack , Cheung Tommy K. , Phung Qui , Haley Benjamin , Lee Byoung-Chul , Akita Robert W. , Sliwkowski Mark X. , Polson Andrew G.
Published: April 2023

Supplementary Figure 1: Loss of cathepsin B in cells. Cathepsin B enzymatic assays for various gRNAs tested against cathepsin B in KPL-4 cells (A) and BT-474M1 (B). IP/WB for cathepsin B expression in KPL-4 cells (C) and BT-474M1 (D). Change in mRNA expression of cathepsin B in BJAB and WSU-DLCL2 cells.
Table S3 from Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation
Authors: Malakar Pushkar , Shilo Asaf , Mogilevsky Adi , Stein Ilan , Pikarsky Eli , Nevo Yuval , Benyamini Hadar , Elgavish Sharona , Zong Xinying , Prasanth Kannanganattu V. , Karni Rotem
Published: April 2023

Table S3. IPA enriched pathways based on RNA-seq analysis
Figure S1 from Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma
Authors: Xu Yang , Taylor Paul , Andrade Joshua , Ueberheide Beatrix , Shuch Brian , Glazer Peter M. , Bindra Ranjit S. , Moran Michael F. , Linehan W. Marston , Neel Benjamin G.
Published: April 2023

H2O2 induces reversible oxidation of classical PTPs.
Supplemental Fig. 1 from Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains
Authors: Peng Hongzhuang , Prokop Jeremy , Karar Jayashree , Park Kyewon , Cao Li , Harbour J. William , Bowcock Anne M. , Malkowicz S. Bruce , Cheung Mitchell , Testa Joseph R. , Rauscher Frank J.
Published: April 2023

The deletion R666-H669 in the ULD domain of BAP1 corresponding to that observed in a uveal melanoma completely abolished ASXL2 binding in vivo. HEK 293 cells were co-transiently transfected with plasmids expressing WT or mutant BAP1 and ASXL2 (261-649aa) proteins. At 48 h post-transfection, the cells were collected and whole cell lysates were used for co-IP with ANTI-Flag M2 Affinity Gel. Western blot analyses were performed with BAP1 (rAb) and Flag (rAb).
Supplemental tables 1-3. IHC reagents and conditions from Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment
Authors: San Martin Rebeca , Pathak Ravi , Jain Antrix , Jung Sung Yun , Hilsenbeck Susan G. , Piña-Barba María C. , Sikora Andrew G. , Pienta Kenneth J. , Rowley David R.
Published: April 2023

Immunohistochemistry conditions and regaents for singe and dual immunohistochemistry
Supplementary Data Summary from Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements
Authors: Seo Jae Ho , Agarwal Ekta , Bryant Kelly G. , Caino M. Cecilia , Kim Eui Tae , Kossenkov Andrew V. , Tang Hsin-Yao , Languino Lucia R. , Gabrilovich Dmitry I. , Cohen Andrew R. , Speicher David W. , Altieri Dario C.
Published: April 2023

Contents of Supplementary Figures ans Table
Supplemental figures 9-11 from Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment
Authors: San Martin Rebeca , Pathak Ravi , Jain Antrix , Jung Sung Yun , Hilsenbeck Susan G. , Piña-Barba María C. , Sikora Andrew G. , Pienta Kenneth J. , Rowley David R.
Published: April 2023

Integrin profiling in prostate cancer-derived cell lines. Integrin alpha nine knock down via siRNA
Supplemental figures 7-8 from Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment
Authors: San Martin Rebeca , Pathak Ravi , Jain Antrix , Jung Sung Yun , Hilsenbeck Susan G. , Piña-Barba María C. , Sikora Andrew G. , Pienta Kenneth J. , Rowley David R.
Published: April 2023

Characterization of the tenascin-c coated trabecular bone scaffold system.
Supplemental figures 3-6 from Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment
Authors: San Martin Rebeca , Pathak Ravi , Jain Antrix , Jung Sung Yun , Hilsenbeck Susan G. , Piña-Barba María C. , Sikora Andrew G. , Pienta Kenneth J. , Rowley David R.
Published: April 2023

Characterization of the osteogenic organoids: Smooth alpha actin expression, viability, co-culture with prostate-derived cell lines. Adhesion of prostate cancer cell lines to tenascin-C
Figure S4 from Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements
Authors: Seo Jae Ho , Agarwal Ekta , Bryant Kelly G. , Caino M. Cecilia , Kim Eui Tae , Kossenkov Andrew V. , Tang Hsin-Yao , Languino Lucia R. , Gabrilovich Dmitry I. , Cohen Andrew R. , Speicher David W. , Altieri Dario C.
Published: April 2023

Regulation of tumor cell invasion by SNPH ubiquitination outside the MBD
Figure S1 from Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements
Authors: Seo Jae Ho , Agarwal Ekta , Bryant Kelly G. , Caino M. Cecilia , Kim Eui Tae , Kossenkov Andrew V. , Tang Hsin-Yao , Languino Lucia R. , Gabrilovich Dmitry I. , Cohen Andrew R. , Speicher David W. , Altieri Dario C.
Published: April 2023

Regulation of SNPH ubiquitination
Supplementary Materials and Methods from CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma
Authors: Ravindran Menon Dinoop , Luo Yuchun , Arcaroli John J. , Liu Sucai , KrishnanKutty Lekha Nair , Osborne Douglas G. , Li Yang , Samson Jenny Mae , Bagby Stacey , Tan Aik-Choon , Robinson William A. , Messersmith Wells A. , Fujita Mayumi
Published: April 2023

Supplementary Materials and methods. Supplementary figure legends. Supplementary table 1 (PDX tumors) and Supplementary table 3(RT PCR primers)
Video 1 from The Digital Slide Archive: A Software Platform for Management, Integration, and Analysis of Histology for Cancer Research
Authors: Gutman David A. , Khalilia Mohammed , Lee Sanghoon , Nalisnik Michael , Mullen Zach , Beezley Jonathan , Chittajallu Deepak R. , Manthey David , Cooper Lee A.D.
Published: April 2023

Video
Supplementary Figure 1 from CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma
Authors: Ravindran Menon Dinoop , Luo Yuchun , Arcaroli John J. , Liu Sucai , KrishnanKutty Lekha Nair , Osborne Douglas G. , Li Yang , Samson Jenny Mae , Bagby Stacey , Tan Aik-Choon , Robinson William A. , Messersmith Wells A. , Fujita Mayumi
Published: April 2023

Effect of tumor digestion protocol on average viable cell number. Related to Figure 1
Supplementary Information from TIP: A Web Server for Resolving Tumor Immunophenotype Profiling
Authors: Xu Liwen , Deng Chunyu , Pang Bo , Zhang Xinxin , Liu Wei , Liao Gaoming , Yuan Huating , Cheng Peng , Li Feng , Long Zhilin , Yan Min , Zhao Tingting , Xiao Yun , Li Xia
Published: April 2023

Supplementary figures and tables
Supplementary Tables S1-S7 from miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells
Authors: Mazzu Ying Z. , Hu Yulan , Soni Rajesh K. , Mojica Kelly M. , Qin Li-Xuan , Agius Phaedra , Waxman Zachary M. , Mihailovic Aleksandra , Socci Nicholas D. , Hendrickson Ronald C. , Tuschl Thomas , Singer Samuel
Published: April 2023

Table S1: Clinicopathologic characteristics of 238 patients with liposarcoma. Table S2: Sources of reagents: antibodies, miRNAs, siRNAs, and inhibitors. Table S3: Primers for MSP, qRT-PCR, and cloning of gene 3'UTR reporters. Table S4: Top 50 differentially expressed miRNAs in DDLS versus normal fat tissues. Table S5: Microarray and SILAC analysis in miRNA-treated liposarcoma cells. Table S6: Identification of miR-193b-targets by integration of transcriptomics, proteomics, and miR-target prediction methods. Table S7: DAVID gene ontology analysis of miR-193b targets.
Supplementary Figures S1-S9 from miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells
Authors: Mazzu Ying Z. , Hu Yulan , Soni Rajesh K. , Mojica Kelly M. , Qin Li-Xuan , Agius Phaedra , Waxman Zachary M. , Mihailovic Aleksandra , Socci Nicholas D. , Hendrickson Ronald C. , Tuschl Thomas , Singer Samuel
Published: April 2023

Figure S1, showing that lower miR-193b expression is associated with poor distant recurrence-free survival. Figure S2, showing the effects of miR-193b and miR-365 on liposarcoma cell growth. Figure S3, showing the effects of forced expression of miR-193b on the transcriptome and proteome in liposarcoma cells and selected gene ontology terms enriched among miR-193b targets. Figure S4, showing that CRKL affects cell proliferation, apoptosis, and expression of cell cycle regulators. Figure S5, showing that FAK affects cell proliferation and apoptosis. Figure S6, showing that miR-193b induces loss of mitochondrial membrane potential. Figure S7:, showing that knockdown of MSRA increases ROS levels and protein oxidation. Figure S8, showing hypermethylation of the miR-193b promoter and expression of DNMT1 in liposarcoma. Figure S9, showing the tumor suppressive activity of miR-193b in vivo.
Supplementary Figure 6 from Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment
Authors: Theodoraki Marie-Nicole , Yerneni Saigopalakrishna , Sarkar Saumendra N. , Orr Brian , Muthuswamy Ravikumar , Voyten Jamie , Modugno Francesmary , Jiang Weijian , Grimm Melissa , Basse Per H. , Bartlett David L. , Edwards Robert P. , Kalinski Pawel
Published: April 2023

The model: Molecular separation of pro-inflammatory and suppressive pathways of dsRNA signaling in cancer TME.
Supplementary figure 4 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming
Authors: Sánchez-Paulete Alfonso R. , Teijeira Álvaro , Quetglas José I. , Rodríguez-Ruiz María E. , Sánchez-Arráez Álvaro , Labiano Sara , Etxeberria Iñaki , Azpilikueta Arantza , Bolaños Elixabet , Ballesteros-Briones María Cristina , Casares Noelia , Quezada Sergio A. , Berraondo Pedro , Sancho David , Smerdou Cristian , Melero Ignacio
Published: April 2023

SFV-XF intratumoral treatment combined with CD4 depletion control the progression of uninjected contralateral tumors.
Supplementary Figure 3 from Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment
Authors: Theodoraki Marie-Nicole , Yerneni Saigopalakrishna , Sarkar Saumendra N. , Orr Brian , Muthuswamy Ravikumar , Voyten Jamie , Modugno Francesmary , Jiang Weijian , Grimm Melissa , Basse Per H. , Bartlett David L. , Edwards Robert P. , Kalinski Pawel
Published: April 2023

IFNÃŽÂ± enhances the response to TLR3 triggering by either poly-I:C or rintatolimod, but prostaglandin inhibition is selectively needed to optimize the pattern of inflammation induced by poly-I:C.
Supplementary figure 3 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming
Authors: Sánchez-Paulete Alfonso R. , Teijeira Álvaro , Quetglas José I. , Rodríguez-Ruiz María E. , Sánchez-Arráez Álvaro , Labiano Sara , Etxeberria Iñaki , Azpilikueta Arantza , Bolaños Elixabet , Ballesteros-Briones María Cristina , Casares Noelia , Quezada Sergio A. , Berraondo Pedro , Sancho David , Smerdou Cristian , Melero Ignacio
Published: April 2023

Cytokine production profiling of CD4+ T cells in draining lymph nodes from mice intratumorally treated with SFV-XF.
Supplementary Figure 2 from Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment
Authors: Theodoraki Marie-Nicole , Yerneni Saigopalakrishna , Sarkar Saumendra N. , Orr Brian , Muthuswamy Ravikumar , Voyten Jamie , Modugno Francesmary , Jiang Weijian , Grimm Melissa , Basse Per H. , Bartlett David L. , Edwards Robert P. , Kalinski Pawel
Published: April 2023

Dose-dependent response to rintatolimod (RINT) and poly-I:C (pIC) in macrophage cultures.
Supplementary figure 2 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming
Authors: Sánchez-Paulete Alfonso R. , Teijeira Álvaro , Quetglas José I. , Rodríguez-Ruiz María E. , Sánchez-Arráez Álvaro , Labiano Sara , Etxeberria Iñaki , Azpilikueta Arantza , Bolaños Elixabet , Ballesteros-Briones María Cristina , Casares Noelia , Quezada Sergio A. , Berraondo Pedro , Sancho David , Smerdou Cristian , Melero Ignacio
Published: April 2023

CD4 Treg depletion or inhibition does not recapitulate the enhancement of efficacy of SFV-XF treatment found with CD4 T-cell depletion.
Supplementary figure 1 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming
Authors: Sánchez-Paulete Alfonso R. , Teijeira Álvaro , Quetglas José I. , Rodríguez-Ruiz María E. , Sánchez-Arráez Álvaro , Labiano Sara , Etxeberria Iñaki , Azpilikueta Arantza , Bolaños Elixabet , Ballesteros-Briones María Cristina , Casares Noelia , Quezada Sergio A. , Berraondo Pedro , Sancho David , Smerdou Cristian , Melero Ignacio
Published: April 2023

The SFV-XF vector exerts maximal antitumor efficacy as compared to SFV vectors encoding each single transgene and is effective against B16F10-derived melanomas, PANC02 pancreatic cancer and CT26 colon cancer.
Figure S8 from Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma
Authors: Meng Jing , Chen Shuang , Han Jing-Xia , Qian Baoxin , Wang Xiao-Rui , Zhong Wei-Long , Qin Yuan , Zhang Heng , Gao Wan-Feng , Lei Yue-Yang , Yang Wei , Yang Lan , Zhang Chao , Liu Hui-Juan , Liu Yan-Rong , Zhou Hong-Gang , Sun Tao , Yang Cheng
Published: April 2023

Figure S8. Kaplan-Meier survival analysis the relationship between survival time of multiple tumors and Twist1 expression. (A) Kaplan-Meier survival analysis of Kaplan-Meier plotter for the relationship between survival time of breast, gastric, ovarian and lung cancer and their expression of Twist1. (B) The relationship between survival time of 75 cases HCC and the Twist1 expression.
Table S1 from Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC
Authors: Sun Haoyu , Xu Jing , Huang Qiang , Huang Mei , Li Kun , Qu Kun , Wen Hao , Lin Renyong , Zheng Meijuan , Wei Haiming , Xiao Weihua , Sun Rui , Tian Zhigang , Sun Cheng
Published: April 2023

Clinicopathological characteristics of each cohort in the study.
Figure S5 from Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC
Authors: Sun Haoyu , Xu Jing , Huang Qiang , Huang Mei , Li Kun , Qu Kun , Wen Hao , Lin Renyong , Zheng Meijuan , Wei Haiming , Xiao Weihua , Sun Rui , Tian Zhigang , Sun Cheng
Published: April 2023

Figure S5 shows (A) Cumulative percentage and MFI of CD160+ NK cells following co-culturing with medium alone, TGF-β1, IL-10, or HCC patient plasma treated with or without anti-TGF-β1 or isotype control for 72h; and (B) CD160 expression level on NK cells from each HC cultured with medium alone at 0h and 72h.
Figure S2 from Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma
Authors: Meng Jing , Chen Shuang , Han Jing-Xia , Qian Baoxin , Wang Xiao-Rui , Zhong Wei-Long , Qin Yuan , Zhang Heng , Gao Wan-Feng , Lei Yue-Yang , Yang Wei , Yang Lan , Zhang Chao , Liu Hui-Juan , Liu Yan-Rong , Zhou Hong-Gang , Sun Tao , Yang Cheng
Published: April 2023

Figure S2. The relationship between circ-10720 expression and patients parameters in HCC. (A) The circ-10720 expression in carbohydrate antigen 199 (CA-199), smoking, drinking negative and positive groups, in female and male groups and whether circ-10720 expression is associated with the origin of bile duct carcinoma (AFP- CA199+). (B) The relationship between circ-10720 expression and enzymes related to liver function (LDH, ALP, ALT, AST). (C) The relationship between circ-10720 expression and albumin (ALB), albumin/ globulin (A/G), carbohydrate antigen 125 (CA-125) and age.
Figure S4 from Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC
Authors: Sun Haoyu , Xu Jing , Huang Qiang , Huang Mei , Li Kun , Qu Kun , Wen Hao , Lin Renyong , Zheng Meijuan , Wei Haiming , Xiao Weihua , Sun Rui , Tian Zhigang , Sun Cheng
Published: April 2023

Figure S4 shows (A) Correlation between peritumoral IOD/area of CD160 and OS or DFS of HCC patients; and (B-C) FACS analysis of CD160 expression in circulating NK cells from HCs, patients with CHB, LC or HCC.
Figures S1-12, Tables S3-6 from IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Authors: Karakasheva Tatiana A. , Lin Eric W. , Tang Qiaosi , Qiao Edmund , Waldron Todd J. , Soni Monica , Klein-Szanto Andres J. , Sahu Varun , Basu Devraj , Ohashi Shinya , Baba Kiichiro , Giaccone Zachary T. , Walker Sarah R. , Frank David A. , Wileyto E. Paul , Long Qi , Dunagin Margaret C. , Raj Arjun , Diehl J. Alan , Wong K.K. , Bass Adam J. , Rustgi Anil K.
Published: April 2023

Fig. S1 demonstrates that human CAFs survive within xenograft tumors Fig. S2 shows the results of quality control for CRISPR-mediated knockout cell lines Fig. S3 shows enhanced tumor growth is ESCC cells are co-implanted with CAF Fig. S4 shows data supporting the role of IL-6 as a mediator of tumor-stroma cross-talk Fig. S5 demonstrates that IL-6 is produced by both ESCC cells and CAFs via RNA in situ hybridization Fig. S6 shows that IL-6 and IL-6Ra are expressed by ESCC cells Fig. S7 shows that exogenous IL-6 rescues the IL-6 knockout phenotype Fig. S8 shows that tocilizumab treatment stalls growth of ESCC and EAC 3D tumoroids Fig. S9 shows the growth curves and IHC staining for pSTAT3, pERK, Ki-67 and cleaved caspase 3 for ESCC tumor xenografts treated with tocilizumab Fig. S10 demonstrates that tosilizumab treatment reduces angiogenesis (via lectin staining) Fig. S11 quantifies the histological changes in tocilizumab-treated xenograft tumors Fig. S12 demonstrates the changes in STAT3 and ERK target gene expression in xenograft tumors in response to tocilizumab treatment Table S3 provides details on the antibodies used for IHC staining Table S4 provides details of linear regression analysis of ESCC and EAC tumor growth kinetics in response to tocilizumab Table S5 provides details of linear regression analysis of HNSCC and gastric cancer tumor growth kinetics in response to tocilizumab Table S6provides details of the mixed effect linear mix model analysis of changes in STAT3 and ERK target gene expression in response to tocilizumab
Supplementary Materials and Methods from Inflammatory Breast Cancer Promotes Development of M2 Tumor-Associated Macrophages and Cancer Mesenchymal Cells through a Complex Chemokine Network
Authors: Valeta-Magara Amanda , Gadi Abhilash , Volta Viviana , Walters Beth , Arju Rezina , Giashuddin Shah , Zhong Hua , Schneider Robert J.
Published: April 2023

Supplementary Materials and Methods for additional procedures
Supplemental Figure 4 from A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity
Authors: Díaz-Carballo David , Saka Sahitya , Klein Jacqueline , Rennkamp Tobias , Acikelli Ali H. , Malak Sascha , Jastrow Holger , Wennemuth Gunther , Tempfer Clemens , Schmitz Inge , Tannapfel Andrea , Strumberg Dirk
Published: April 2023

Replicative elements found in P1 and G1 cells and the expression of HERV envelope proteins in small G1-G2 cells can be visualised here.
Supplemental Figure 3 from A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity
Authors: Díaz-Carballo David , Saka Sahitya , Klein Jacqueline , Rennkamp Tobias , Acikelli Ali H. , Malak Sascha , Jastrow Holger , Wennemuth Gunther , Tempfer Clemens , Schmitz Inge , Tannapfel Andrea , Strumberg Dirk
Published: April 2023

P1 oncogenerative cell division as a whole cell entity is shown here.
Supplemental Figure 2 from A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity
Authors: Díaz-Carballo David , Saka Sahitya , Klein Jacqueline , Rennkamp Tobias , Acikelli Ali H. , Malak Sascha , Jastrow Holger , Wennemuth Gunther , Tempfer Clemens , Schmitz Inge , Tannapfel Andrea , Strumberg Dirk
Published: April 2023

Depiction of funiculus cellularis, crevices and G1-Gn cell eclosion.
Supplementary Figure Legend from Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells
Authors: Jounaidi Youssef , Cotten Joseph F. , Miller Keith W. , Forman Stuart A.
Published: April 2023

Supplementary Figure Legend including Supplementary Table 1: Primers used for Expression profiles of cytotoxicity effectors in NK92, NK92IL2 and NK92CIRB. Supplementary Tabel 2: Impact of direct contact with cancer cells on NK cells expression profiles of natural cytotoxicity and effectors. Supplementary Figure 1: Representation of the chimera CIRB. Supplementary Figure 2: Cell growth of NK92IL2 and NK92CIRB cell lines.
Supplemental Figure 1 from A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity
Authors: Díaz-Carballo David , Saka Sahitya , Klein Jacqueline , Rennkamp Tobias , Acikelli Ali H. , Malak Sascha , Jastrow Holger , Wennemuth Gunther , Tempfer Clemens , Schmitz Inge , Tannapfel Andrea , Strumberg Dirk
Published: April 2023

Occurrence and morphology of multinucleated cells in different tumors.
Figure S2 from Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells
Authors: Jounaidi Youssef , Cotten Joseph F. , Miller Keith W. , Forman Stuart A.
Published: April 2023

Cell growth of NK92IL2 and NK92CIRB cell lines.
The GDC Application Programming Interface (API) from Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API
Authors: Wilson Shane , Fitzsimons Michael , Ferguson Martin , Heath Allison , Jensen Mark , Miller Josh , Murphy Mark W. , Porter James , Sahni Himanso , Staudt Louis , Tang Yajing , Wang Zhining , Yu Christine , Zhang Junjun , Ferretti Vincent , Grossman Robert L.
Published: April 2023

This video gives an overview of the GDC Application Programming Interface (API), which makes available to third party applications all of the data available in the GDC.