bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodology for the development and application of clinical decisions support information technologies with consideration of civil-legal grounds
Authors: Hnatchuk Yelyzaveta , Hovorushchenko Tetiana , Pavlova Olga
Published: April 2023

Currently, there are no clinical decision support information technologies (CDSIT) that would consider civil-legal grounds when forming a decision for clinicians. Therefore, the design, development, and implementation of CDSIT, which considers civil-legal grounds when forming decisions, are actual problems. Methodology for the development and application of knowledge-driven, rule-based, clinical decisions support information technologies with consideration of civil-legal grounds has been developed, which provides a theoretical basis for developing clinical decisions support information technology with consideration of civil-legal grounds and partial CDSITs regarding the possibility of providing medical services of a certain type. In addition to the conclusion about the possibility or impossibility of providing certain medical services, the developed methodology ensures the presence of all essential terms (from the viewpoint of civil law regulation) in the contract for the certain medical service's provision and/or the data on potential patients for the provision of such a service, as well as minimization of the influence of the human factor when making clinical decisions. It is advisable to evaluate the CDSITs with consideration of civil-legal grounds, developed according to the proposed methodology, from the viewpoint of the correctness of the decisions generated by them, as well as from the viewpoint of their usefulness for clinics. In this paper, experiments with the methodology-based CDSIT regarding the possibility of performing a surrogate motherhood procedure with consideration of civil-legal grounds were conducted. Such experiments showed the correctness of the generated decisions at the level of 97 %. Experiments also demonstrated the usefulness of such IT for clinics from the viewpoint of eliminating adverse legal consequences, as they might arise due to violation or disregard of legal, and moral and ethical norms.
Improving the accuracy of the PET/MRI tridimensional multimodal rigid image registration based on the FATEMD
Authors: Taime Abderazzak , Khamjane Aziz , Riffi Jamal , Tairi Hamid
Published: April 2023

The subject matter of the article is the improvement in the accuracy of multimodal image registration between PET and MRI images in the medical field. The focus of the article pertains to the importance of these images in diagnosis, interpretation, and surgical intervention. This study increased the accuracy of PET/MRI multimodal image registration achieved through a new approach based on the multi-resolution image decomposition. The tasks to be solved are: The study proposes a new method, the fast and adaptive three-dimensional mode decomposition (FATEMD), to generate multi-resolution components for accurate registration. The method used: The study uses the FATEMD approach, which estimates the transformation parameters of the registration from the PET image and the residue of the second level of the MRI image that is obtained after the extraction of the first two tridimensional intrinsic mode functions (TIMFs). The following results were obtained: The proposed method of multimodal registration between PET and MRI images involves the use of the fast and adaptive three-dimensional mode decomposition (FATEMD) approach. This approach was tested on 25 pairs of images from the Vanderbilt database and was found to have improved accuracy compared to the usual method, as shown through comparative studies using measures of mutual information, normalized mutual information, and entropy correlation coefficient. Conclusion. The main objective achieved in the study was to enhance the accuracy of PET/MRI multimodal image registration through the application of the FATEMD decomposition method. This approach is novel compared to traditional methods as it involves estimating the transformation parameters from the PET image and the second level residue of the MRI image, resulting in more precise outcomes as opposed to using just the PET and MRI images alone. The integration of multiple imaging techniques, such as PET and MRI, provides healthcare professionals with a more comprehensive view of a patient's anatomy and physiology, leading to enhanced diagnosis and treatment planning.
Peculiarities of the formation of sperm production and the course of peroxide oxidation in boars
Authors: Shostya A. M. , Zamazii A. A. , Usenko S. O. , Shpyrna I. G.
Published: April 2023

The intensive use of boars and receiving biologically complete valuable ejaculates from them is possible due to early assessment of the quality of sperm production and timely determination of their genetic potential. The research aimed to determine the peculiarities of the formation of sperm production and the course of peroxide oxidation in boars during puberty. For the experiment, 5–10 month-old boars of Poltava Meat, the Large White, and Myrhorod breeds were used. The quality of the obtained ejaculates was evaluated according to standard indicators according to the instructions for artificial insemination of pigs. The research results indicate a significant increase in the quantitative indexes of sperm production in young boars in the age range with different features for each breed. By the eighth month of life, a general tendency to increase the parameters in the received ejaculates is noted. In contrast, the highest increase in ejaculate volume and sperm concentration was found in young boars of the sebaceous direction of productivity on the 240th day of the development (4.6 and 1.9 times). The minimum motility and survival of gametes were observed at five months, regardless of the breed, with a gradual increase to maximum values at the seventh and eighth months of age, depending on the direction of animal productivity. The use of moderate sexual load for young boars after they reach the age of 9 months ensures the functional activity of sperm suitable for artificial insemination (motility above 80 % and survival above 70 %). The significant changes in the pro-oxidant-antioxidant homeostasis in the sperm of boars of 7–8 months occur in the direction of the acceleration of the peroxygen oxidation of lipids, which is evidenced by an increase in the content of diene conjugates and TBC-active compounds and an increase in the activity of enzymes of the antioxidant link. An earlier formation of pro-oxidant-antioxidant homeostasis in this secretion is noted in representatives of the meat and fat direction of productivity. Thus, the obtained results indicate significant age-related changes in the ejaculate parameters and peculiarities of the course of peroxide oxidation processes depending on the breed of boars.
Effectiveness of fattening cattle on diets of different energy levels with the use of probiotic feed additive “PROGALplv”
Authors: Mil O. O. , Pivtorak Ya. I.
Published: April 2023

A full-fledged yearling of young cattle should be based on scientifically based standards, guaranteeing their genetic productivity potential, rational use of feed resources, and proper payment for feed with meat products. The current situation regarding the rationing of yearling livestock in global and domestic, both scientific and production practices, has fundamentally changed, which requires a significant revision of traditional provisions on the organization of rationed yearling and feeding of farm animals. At the same time, the conceptual requirements for the organization of standardized feeding of young livestock should be based on the general world experience of the need for energy, nutrients, and biologically active substances of animals, taking into account the age period of the growing season, with an emphasis on the quality and biosafety of products. In the intensive production of meat products, to ensure high productivity, it is only possible to do so by using feed products of natural substance, which should include additives with a phytobiological effect. One of these consists of the feed supplement “PROGALplv,” which contains the probiotic component maltodenstrin and fructooligosaccharides and belongs to the probiotic supplement for ruminants. Based on the research, optimizing the standardized feeding of fattening young animals on diets with different energy levels and using the biological feed additive “PROGALplv” at the rate of 6, 10, and 15 g/head was set a day. The research was conducted on Simmental bulls in the conditions of the farm “Pchany-Denkovych” of the Stryi district of the Lviv region. It was established that using “PROGALplv” bio-additives in the ration against the background of different energy nutrition contributed to an increase in the intensity of physiologically helpful microflora of the rumen, which had a stimulating effect in the processes of additional assimilation of nutrients. A positive result was obtained regarding the average daily gains and quality indicators of meat products and the economic efficiency of the final fattening period. Thus, based on the results of our research, it is possible to recommend the introduction of an increased level of energy nutrition of 110 % of the explicit norms into the intensive technology of livestock removal at the expense of an entirely rational feed mixture with the inclusion of the probiotic feed additive “PROGALplv” at the rate of 10 g/head per day. The optimal introduction dose to compound feed compliance is 10 g/head. The maximum amount can be no more than 15 g/h. daily. No adverse side effects of “PROGALplv” bio-additives on the general functional condition of Bugai residents were found.
Gastrointestinal parasitosis of sheep on farms of the Poltava region
Authors: Korchan L. , Melnychuk V. , Zamaziy A. , Prykhodko Yu.
Published: April 2023

Sheep breeding is one of the most promising branches of agriculture and the most important branch of animal husbandry worldwide. For the successful development of the industry mentioned above, it is necessary to increase the number of sheep and the production of livestock products. One of the aspects of this task is the effective implementation of measures to control parasitic diseases in sheep, particularly those localized in the gastrointestinal tract. The work aimed to investigate the spread of gastrointestinal parasitoses among sheep of single-person peasant farms in the Poltava region. The studies established that the average infestation of sheep by causative agents of gastrointestinal parasitoses is 39.74 %. In the studied sheep, strongylidoses of the digestive organs (extensiveness of invasion – 20.19 %), trichuriasis (18.59 %), eimeriosis (18.27 %), monieziosis (6.73 %), strongyloidosis (6.73 %) and dicrocoeliosis (1.92 %). In 32.26 % of the studied animals, the invasions occurred in monoinvasions, and in 67.74 % – in the form of mixinvasions. Among the monoinvasions, dicrocoeliosic (10 % of monoinvasions), monieziosic (22.5 %), strongyloidosic (40 %), and eimeriosic (27.5 %) were recorded. A total of 10 types of mixinvasions were detected in sheep, where two-component associations of gastrointestinal parasites were most often registered (78.57 % of mixinvasions), and three-component associations of parasites were less frequently diagnosed (21.43 %). Among the two-component mixinvasions, strongyloidosic- eimeriosic and trichuriasic- strongyloidosic were most often diagnosed, where the indicators of the extensiveness of invasions were 5.77 and 5.13 %, respectively. Three-component mixinvasions were represented by an association of trichurises, strongylides of digestive organs and eimeries (3.21 %), trichurises, strongyloideses and eimeries (1.60 %) and moniezies, trichurises, and strongylides of digestive organs (0.96 %). The research results on the spread of gastrointestinal parasitoses in sheep will allow for taking into account the peculiarities of the course of mixinvasions and the composition of their co-members when carrying out treatment and preventive measures in single-person peasant farms of the studied region.
ОСОБИСТІСНА ЗРІЛІСТЬ МОЛОДІ КРІЗЬ ПРИЗМУ РОСІЙСЬКО-УКРАЇНСЬКОЇ ВІЙНИ
Authors: Угрин Ольга Георгіївна , Лучка Тетяна
Published: April 2023

У статті з’ясовано особливості прояву особистісної зрілості молоді. Проаналізовано показники особистісної зрілості (глибинність переживань, відповідальність та децентрацію), які є найбільш актуальними та важливими під час російсько-української війни. З’ясовано копінг-стратегії (знання, віру та уяву), на які найчастіше спирається молодь. Встановлено зв’язки між показниками особистісної зрілості, особистісними рисами та копінг-стратегіями. Так, чим більш відповідальною є людина, тим більш важливими є контакти, уява та прояв нейротизму. Водночас відкритість до нового досвіду, поступливість та уява дають можливість молоді поглянути на речі і явища з різних боків, а відтак розширити межі розуміння, перейти із «зони комфорту» в «зону росту й розвитку», що дає розуміння та прийняття інакшості в інших і собі. Встановлено також вікові особливості у прояві особистісної зрілості. Зокрема, з віком зростає автономія та відповідальність.
КАМЕРНА МУЗИКА НА ШЛЯХУ УКРАЇНСЬКОЇ НАРОДНОСТІ
Authors: РУКОМОЙНІКОВА Олександра , РЯБІНІН Олексій
Published: April 2023

Народна українська музика, пройшовши нелегкий історичний шлях, вистоявши і відвоювавши право глибинної поваги, на етапі становлення сучасності та розвитку вільної незалежної України є національно-культурним, духовно-патріотичним надбанням, яке впливає на становлення української національної свідомості сучасного покоління, сприяє вдосконаленню та втіленню національних уявлень та особливостей нашого народу у часі та просторі на соціально-культурний розвиток. Вивчення та збереження своїх національних коренів, заглиблення вивчення фольклорних першооснов, освітлення та окреслення української культури дає поштовх до об’єднання творчої фантазії, який може свіжо та цікаво, плідно та інноваційно поєднуватися з сучасними жанрами, тенденціями, стилями музичного майбутнього. Українська народна музика вражає своєю колоритністю і різнобарвністю, в кожному селі чи містечку свої пісні, колядки, музика, своя історія. Фольклор – це живий організм, із своїми шрамами та оновленнями, не суха мумія, а вічно молода красуня, яка завдяки пам’яті свого народу постійно перетворюється, оновлюється і стає багатше. Велику роль народна українська музика грає в камерно-інструментальній музиці. За десятиліття, ми спостерігаємо за розвитком і творчим ростом сотень майстрів музичної творчості, які прославляють нашу державу. І головне завдання сучасності перенести із історичного минулого, через різноманітне сьогодення у таємне майбутнє. Українську музику чують і співають у всьому світі. Гімн нашої держави лунає в різних куточках планети на підтримку нашої сили і незламності. Наша славетна історія, завжди супроводжувалася музикою. Захисники, солдати, які захищали, захищають і будуть захищати нашу неньку ідучи у бій, відпочиваючи після атаки, при поранені співають пісні, згадуючи і єднаючись із своїм домом і близькими.
БОГОСЛУЖБОВИЙ СПІВ У КОМПОЗИТОРСЬКІЙ ІНТЕРПРЕТАЦІЇ (НА ПРИКЛАДІ «ВЕЛИКОГО СЛАВОСЛІВ’Я» З «ВСЕНІЧНОЇ» К. СТЕЦЕНКА)
Authors: ЯСТРУБ Олена
Published: April 2023

Заявлена наукова проблема пов’язана з актуалізацією шедеврів духовної композиторської творчості представників «нової національно-української церковної музики» (Н. Супрун-Яремко) першої третини ХХ століття у дослідницькій та виконавській царині. Духовна літургійна композиторська творчість К. Стеценка привертає увагу сучасних дослідників, зокрема, в аспекті самобутньої композиторської інтерпретації богослужбової традиції та сучасної виконавської рефлексії. Метою нашої наукової статті є розгляд богослужбового співу у композиторській інтерпретації на прикладі «Великого славослів’я» (1921) з «Всенічної» К. Стеценка у виконавській інтерпретації камерного хору «Київ» (диригент М. Гобдич, 2013). Методологія наукової розвідки базується на поєднанні історико-культурологічного, жанрового, стильового, композиційно-драматургічного, інтерпретаційного підходів. Наукова новизна отриманих результатів дослідження пов’язана з виявленням інноваційних жанрово-стилістичних ознак літургійної творчості К. Стеценка на прикладі «Великого славослів’я» з «Всенічної» в аспекті спадкоємності традиції духовного співу та здійсненого інтерпретаційного аналізу виконавської версії, що постає еталонним зразком в сучасній виконавській практиці (камерний хор «Київ»). Духовний стрій «Великого славослів’я» К. Стеценка увиразнює органічне поєднання хвалебного гімну і покаянної молитви. Апелюючи до псалмодичного типу викладу, композитор комбінує речитативність з наспівною мелодією-наспівом. У Висновках обґрунтовується погляд на літургійну хорову творчість К. Стеценка як втілення тенденцій національного стилеутворення у музичній культурі України першої третини ХХ століття, що визначається спадкоємністю традиції богослужбового співу та опорою на засади національної народної пісенності.
A Multimodal Discourse Analysis of the Geographical Indication trademark of China Intangible Cultural Heritage
Authors: Mei Zheng , Xin Wang
Published: April 2023

Guided by the theories of systemic functional linguistics and social semiotics, this paper analyzes the specific embodiment of representational, interactive and compositional meanings of the geographical indication trademark of China intangible cultural heritage within the theoretical framework of multimodal discourse analysis. Based on the analysis results, this paper aims to reveal the effective linkage and meaning construction of language and images while expressing the deep value meaning of intangible cultural heritage geographical trademark and provide ideas to raise people’s concern over and multimodal literacy of China intangible cultural heritage, thus better protect and promote it.
Analisis Waste Produksi Celana Dengan Metode Lean Six Sigma Pada Area Sewing Line 5 Di PT. XYZ
Authors: Munandar Ahmad , Permana Delfiana Sandi
Published: April 2023

PT. XYZ merupakan salah satu perusahaan di kota Cimahi yang bergerak dalam produksi garmen. Pada proses produksi sewing di PT. XYZ terdapat permasalahan, yaitu hasil produksi tidak sesuai dengan target aktual perusahaan, diketahui juga dari delapan line yang ada line 5 merupakan tingkat pencapaian produksi terendah sebesar 60,95% dari pada line lainnya. Terdapat beberapa hal yang memengaruhi perbedaaan tersebut, yaitu dikarenakan masih banyak ditemukan kualitas tidak sesuai dengan standar (reject) sehingga pada akhirnya mengakibatkan terjadinya proses pengerjaan ulang produk (rework), pemborosan tersebut perlukan untuk dihilangkan dengan mengunakan konsep lean six sigma dengan tahapan (DMAIC). Â Pada tahap define ini identifikasi melalu pengidentifikasian waste dilakukan dengan menggunakan metode SIPOC, Value Stream Mapping (VSM), Waste Assessment Model (WAM). Pada tahap measure menetukan CTQ dan mengetahui nilai DPMO dan nilai sigma. Pada tahap analyze yaitu mengetahui penyebab terjadinya waste dengan menggunakan diagram pareto dan diagram sebab akibat. Pada tahap improve mengetahui penilaian RPN FMEA yang tertinggi dan memberikan usulan perbaikan pada waste. Â Berdasarkan hasil penelitian didapatkan identifikasi melalu pengidentifikasian waste dengan menggunakan metode Waste Assessment Model (WAM) yang menghasilkan peringkat waste tertinggi yaitu defect 23.94%,dengan CTQ-30 dan DPMO sebesar 6968.84 dan nilai sigma sebesar 3.96 sigma. Faktor penyebab menggunakan diagram pareto, dapat diketahui jenis 11 cacat produk yang dominan dan diagram sebab akibat, penyebab waste defect terdapat 4 faktor, yaitu manusia, material, metode dan mesin. Perbaikan berdasarkan nilai RPN FMEA yang tertinggi berdasarkan manusia adalah diberikan arahan dan bimbingan sesuai SOP, selanjutnya pengawasan yang ketat dan untuk mesin yaitu menerapkan preventive maintenance dalam melakukan kegiatan perawatan mesin.Kata kunci: Lean Six Sigma, DMAIC ,VSM,WAM ,DPOM,FMEA
Một kỹ thuật biến đổi giọng người nói hiệu quả sử dụng kỹ thuật phân rã tiếng nói theo thời gian
Authors: Nghĩa Phùng Trung
Published: April 2023

Voice transformation is an important issue in speech synthesis when we need to synthesize multiple output voices but do not want to rebuid the synthesis system. Speech transformed by the conventional method using Gaussian Mixture Model (GMM) is not high-quality due to the oversmoothness of GMM. Therefore, a number of methods have been proposed to overcome the disadvantages of the conventional method using GMM. Among them, Hidden Markov Model Trajectory Tiling (HTT) and Temporal Decomposition – GMM (TD-GMM) improve the effectiveness of voice transformation. However, they still have drawbacks. In this paper, a voice transformation method using the modified restricted TD (MRTD) is proposed. The experimental results with Vietnamese and English corpus confirm the effectiveness of the proposed method compared with HTT and TD-GMM.
Pricing of Ijara: An Alternative Model Based on Musharaka
Authors: Hidoussi Ibrahim
Published: April 2023

يعتبر التسعير في المعاملات الآجلة من أبرز التحديات التي تواجهها المالية الإسلامية باعتبار قيامها على السعر المضاف للمستقبل الذي يواجه مخاطر الانزلاق نحو الربط بأسعار الفائدة على غرار الليبور. وحيث تقوم هذه الورقة على اقتراح بديل يغني عن هذا المطب ويراعي جوهر المعاملات المالية الإسلامية القائم على المشاركة في المخاطر والمكاسب، وهو البديل القائم على المشاركة. وهذا المقترح ينطلق من التكييف الفقهي لمنتج الإجارة لدى بعض التيارات الفقهية. وحيث ينتهي هذا البحث إلى استنباط طريقة في احتساب العوائد على الإجارة يقوم على تعديل السعر تلقائيا على امتداد العقد بدخول عنصر المشاركة كمكوّن أساسي من مكونات العقد. وقد تمت معالجة الإشكالية التي يطرحها البحث باستقراء الأدلة الشرعية وتحليل نماذج التسعير المعتمدة لاستنباط النموذج المناسب للصيغة المقترحة لمنتج الإجارة. كلمات مفتاحية: الإجارة، التسعير، المشاركة، الأجل
Inteligencia artificial en diagnóstico, pronóstico y planificación del tratamiento de alteraciones de la región cráneo-cérvico maxilofacial en ortodoncia. Revisión de la literatura
Authors: Bravo Medina Pablo Ramiro , Pulgarin Fernández Celia María , Ramos Montiel Ronald Roossevelt
Published: April 2023

Introducción: La incorporación de la tecnología informática en el diagnóstico, pronóstico, planificación de tratamiento de la región cráneo-cérvico maxilofacial en el área de la salud, ha ido evolucionando a lo largo de los años hasta incorporar estas tecnologías como un auxiliar en estos procedimientos denominada como inteligencia artificial IA, en las últimas décadas ha contribuido a reducir los costos, tiempo, experiencia del profesional y ciertos errores. Objetivo: Esta revisión de la literatura pretendió organizar de manera ordenada la literatura existente sobre la implementación de la IA en salud y el diagnóstico ortodóncico, además de las limitaciones del tema. Métodos: Se realizó mediante la búsqueda electrónica extensiva en diversas bases de datos digitales como Pubmed, Springer, Cochrane, Taylor & Francis y Web of Science, sin temporalidad de tiempo ni exclusión idiomas. Resultados: Para esta revisión se estableció un registro de base de datos un total de 428 estudios. Se realizo un primer cribado dejando 376 artículos; luego de esta selección, se eliminó la bibliografía duplicada, quedando 321 artículos, se excluyeron estudios que no cumplieron con los criterios de selección, lo que resultó en 40 incluidos. Conclusiones: De la literatura existente se encontró que debido a su baja exactitud la IA no se los podría considerar como una herramienta diagnostica definitiva, sino como una ayuda en el diagnóstico, pronóstico y planificación de tratamientos ya que hasta ahora ninguna maquina podría superar la inteligencia humana, pero debemos tener en cuenta que con el aumento de las investigaciones sobre IA en el área de la salud, esta podría a llegar a convertirse en una herramienta muy valiosa especialmente en el campo de la impresión 3D, que ayuda en la fabricación de aparatos accesorios que podrían potenciar los tratamientos de alteraciones en cabeza y cuello.
Design and Development of a Low-Cost 2.4 GHz GFSK Modulation based Walkie-Talkie
Authors: Hashmi Galib , Huda Md Nazmul , Mamun Md Kowsar Hossain , Rahman Md Habibur
Published: April 2023

A walkie-talkie device can be quite useful in the location where there is no cellphone coverage. Even in the cellphone coverage area it provides communication at very low cost. Currently the law enforcement and military personnel uses frequency modulation (FM) based walkie-talkie systems. The main goal of this research is to design and develop a lowcost walkie-talkie device that can be used by anyone other than the military and law enforcement personals. To construct the walkie-talkie system, the 2.4 GHz industrial, scientific, and medical (ISM) band and GFSK modulation technology have been chosen. In addition, the device includes transceiver module, dc power source, microphone amplifier, audio amplifier, dc-dc booster, and speaker. The coverage range of the implemented walkie-talkie system has been determined and found up to 200 meters. The gadget incorporates a li-ion battery charging system. The voltage, current and power levels at various locations of the device have been measured. It has been found that the maximum operating power consumption is 4.81W and standby power is 1mW. Moreover, the waveforms of different signals at different points of the systems have been observed on the oscilloscope. All of the development process of the system and the performance data are presented in this paper.
DUJASE Vol. 7 (2) 16-20, 2022 (July)
Barriers of Researches in Medical Sector in Bangladesh-The Curtain in the Window
Authors: Jahan Shah Md Sarwer
Published: April 2023

Abstract not available

J Rang Med Col. September 2023; Vol. 8, No. 1:1-2
Evaluation of Estimated Glomerular Filtration Rate in Obese Male Adults and Its Correlation with BMI
Authors: Akhter Safina , Sarkar Chandra Rani , Zahid ATM Zoadur Rahim
Published: April 2023

Background: Overweight and obesity has been announced as a global epidemic by The World Health Organization. These conditions have strong associations with renal function impairment.
Objectives: To evaluate the estimated glomerular filtration rate (eGFR) in obese male adults and to observe the correlation of eGFR with body mass index (BMI).
Methods: This cross-sectional analytical study was conducted at the Department of Physiology, Rangpur Medical College, Rangpur. After briefing about objectives, adult males who met the inclusion and exclusion criteria were enrolled in the study by consensus. The study involved 60 people who were divided into two groups: apparently healthy adult males of average weight (Group A) and apparently healthy adult males who were obese (Group B). The subjects were selected from different districts of the city of Rangpur. Their body mass index & serum creatinine were measured. eGFR was calculated by Cockcroft-Gault equation using serum creatinine. For statistical analysis, unpaired t-test and Pearson’s correlation coefficient test were performed as applicable by computer-based SPSS–25.0 for windows. Regarding the interpretation of results, p≤0.05 was accepted as significant.
Results: The mean of estimated glomerular filtration rate was significantly (p≤ 0.001) lower in obese male adults than in normal-weight male adults. This study also found a highly significant (p≤0.05) negative correlation of eGFR (r = -0.317) with body mass index.
Conclusion: eGFR is reduced in obese male adults, and it is negatively correlated with BMI. Regular body mass index screening is recommended as an easy and effective means of assessing body weight.
J Rang Med Col. March 2023; Vol. 8, No. 2:27-32
Isoniazid-induced Encephalopathy in a Patient with Pott’s Disease with Chronic Kidney Disease: A Case Report
Authors: Miah Md Helal , Bakas Md Ahad , Hossein Md Kamal , Begum Tahmina , Alam Md Shafiul , Kabir Md Jahangir , Mondol Abu Said Md Rahenur , Sarkar Md Ruhul Amin , Anwar Md Mahfuj Ul , Jahan Shah Md Sarwer , Rahman Md Mahfuzer
Published: April 2023

We report an isoniazid-induced encephalopathy in a man with chronic renal failure. Drug-induced encephalopathy is a common side effect of many drugs. Isoniazid (INH), a first-line drug for tuberculosis, can cause encephalopathy in patients with chronic kidney disease (CKD). For Pott's disease of the thoracic spine, he received rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine and prednisolone. But the patient is free of pyridoxine for two and a half months. Subsequently, after treatment, the patient experienced recurrent episodes of altered consciousness, irrelevant conversations, and disorientation. After ruling out other causes, isoniazid-induced encephalopathy was suspected and confirmed by improvement of symptoms after discontinuation of high-dose isoniazid and pyridoxine.
J Rang Med Col. March 2023; Vol. 8, No. 1:72-75
EDUCAÇÃO DE JOVENS E ADULTOS, ENSINO DE BIOLOGIA, TEORIA HISTÓRICO-CULTURAL E PEDAGOGIA HISTÓRICO-CRÍTICA: RELAÇÕES EM PESQUISAS DE PÓS-GRADUAÇÃO
Authors: Martins de Avelar Lucas , De Deus Paranhos Rones
Published: April 2023

Este estudo é o desdobramento de uma investigação de mestrado e objetiva analisar as relações entre a Educação de Jovens e Adultos, o Ensino de Biologia, a Teoria Histórico-Cultural (THC) e a Pedagogia Histórico-Crítica (PHC) em pesquisas de pós-graduação brasileiras com propostas de intervenção didática. Empregou-se a metodologia do Estado do Conhecimento, com recorte temporal de 1997 a 2019 e seleção das produções no Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Foram selecionadas e analisadas 15 dissertações. Os resultados indicam que a THC e PHC não se configuram nos principais referenciais das pesquisas e seu emprego ocorre de forma majoritariamente incidental. Os nexos estabelecidos pelos trabalhos são insipientes e focalizam o cotidiano e as experiências de vida dos sujeitos. Defende-se a necessidade de uma abordagem teórico-epistemológica a partir do Materialismo Histórico-Dialético, na qual a Teoria Histórico-Cultural e a Pedagogia Histórico-Crítica sejam mediação viva para os vínculos sintéticos entre o conhecimento biológico e a modalidade, em uma perspectiva de organização do ensino-aprendizagem para o desenvolvimento humano omnilateral. 
Palavras-chave: EJA. THC. PHC. Conhecimento biológico. Estado do conhecimento.
 
ABSTRACT
Este estuThis study is the unfolding of a master's investigation and aims to analyze the relationships between Youth and Adult Education, Biology Teaching, Historical-Cultural Theory (THC) and Historical-Critical Pedagogy (PHC) in postgraduate research. Brazilian undergraduate courses with didactic intervention proposals. The State of Knowledge methodology was used, with a time frame from 1997 to 2019 and selection of productions in the Catalog of Theses and Dissertations of the Coordination for the Improvement of Higher Education Personnel (CAPES). Fifteen dissertations were selected and analyzed. The results indicate that THC and PHC are not the main research references and their use is mostly incidental. The connections established by the works are incipient and focus on the subjects' daily life and experiences. The need for a theoretical-epistemological approach based on Historical-Dialectic Materialism is defended, in which Historical-Cultural Theory and Historical-Critical Pedagogy are living mediation for the synthetic links between biological knowledge and modality, in a perspective organization of teaching and learning for omnilateral human development.
Keywords: EJA. THC. PHC. Biological knowledge. State of knowledge.
KEMAMPUAN MANAJERIAL TERHADAP KINERJA PENGURUS BUMDES
Authors: Rusdi Muhammad , Madaling Madaling , Said Sunandar
Published: April 2023

Pembangunan bertujuan untuk meningkatkan kemandirian taraf hidup dan kesejahteraan masyarakat, termasuk pembangunan perdesaan. Badan Usaha Perdesaan (BUMDes) adalah badan usaha komersial yang didirikan oleh pemerintah desa untuk merevitalisasi dan mengembangkan perekonomian pedesaan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kemampuan manajemen terhadap kinerja manajemen BUMDes di Kabupaten Sidenreng Rappang. Metode penelitian yang digunakan dalam penelitian ini adalah kuantitatif dengan pendekatan cross sectional. Subjek penelitian ini adalah pengelola utama BUMDes di Kabupaten Sidenreng Rappang. Pengumpulan data dilakukan dengan menggunakan alat bantu berupa kuesioner. Selain itu, data dianalisis dengan menggunakan analisis regresi linier sederhana. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh yang signifikan dan positif kemampuan manajemen terhadap kinerja BUMDes di Kabupaten Sidenreng Rappang. Kata kunci: BUMDes, kemampuan manajerial, kinerja ABSTRACT Development aims to improve the independence of living standards and social well-being, including the development of rural areas. Village Enterprises (BUMDes) are commercial enterprises established by village governments to revitalize and develop the rural economy. The purpose of this study was to determine the effect of management ability on management performance of BUMDes in Sidenreng Rappang Regency. The research method used in this study is a quantitative, cross-sectional approach. The subject of this study is the principal manager of BUMDes at the Sidenreng Rappang Regency. Data were collected using the tool in the form of a questionnaire. In addition, data were analyzed using simple linear regression analysis. The results of this study showed that there was a significant and positive impact of management ability on the performance of BUMD in Sidenreng Rappang Regency. Keywords: BUMDes, Managerial Ability, Performance.
DAMPAK NILAI PERUSAHAAN YANG DIPENGARUHI KEPUTUSAN INVESTASI, STRUKTUR MODAL, DAN KEBIJAKAN DIVIDEN
Authors: Yunaningsih Yuyun , Widhiastuti Susanti
Published: April 2023

Penelitian ini bertujuan untuk menguji dampak nilai perusahaan yang dipengaruhi keputusan investasi, struktur modal, dan kebijakan dividen pada perusahaan sektor industri dasar dan kimia yang terdaftar di Bursa Efek Indonesia periode 2017-2020. Data dalam penelitian menggunakan data sekunder dari 15 perusahaan sektor industri dasar dan kimia yang terdaftar di BEI. Teknik analisis menggunakan regresi linier berganda yang diolah menggunakan SPSS. Hasil penelitian ini ialah keputusan investasi berdampak positif signifikan terhadap nilai perusahaan, sementara kebijakan dividen dan struktur modal berdampak positif tidak signifikan terhadap nilai perusahaan. Kata kunci: kebijakan dividen, keputusan investasi, nilai perusahaan, struktur modal  ABSTRACT This study aims to examine the impact of firm value on investment decisions, capital structure and dividend policy on basic and chemical industrial sector companies listed on the Indonesia Stock Exchange for the 2017-2020 period. The data in this study uses secondary data from 15 basic and chemical industrial sector companies listed on the IDX. The analysis technique uses multiple linear regression which is processed using SPSS. The results of this study are that investment decisions have a significant positive impact on firm value, while dividend policy and capital structure have an insignificant positive impact on firm value. Keywords: capital structure, dividend policy, firm value, investment decision
IMPAK GAYA KEPEMIMPINAN DAN MOTIVASI KERJA ATAS KINERJA KARYAWAN PADA INDUSTRI PADAT KARYA DI BOGOR
Authors: Mulyana Dede , Utama Angka , Widodo Widodo , Cecep Cecep
Published: April 2023

Tujuan dari peneltian ini untuk melakukan uji impak gaya kepemimpinan juga motivasi kerja atas kinerja karyawan di industri padat karya di Bogor. Maka pada pelaksanaannya digunakan metode deskriptif, melakukan uji (butir pernyataan, korelasi, regresi simpel dan ganda, determinan, serta parsial, simultan). Keluaran regresi diperoleh ada impak yang nyata antara gaya kepemimpinan atas variabel kinerja karyawan. Kesimpulannya adalah gaya kepemimpinan yang baik mampu menaikan kinerja karyawan. Motivasi berpengaruh kuat atas kinerja karyawan. Hasil uji regresi diperoleh ada impak yang nyata (signifikan) motivasi atas kinerja karyawan. Artinya semakin baiknya motivasi akan meningkat pula kinerja karyawan. Gaya kepemimpinan, motivasi kerja secara simultan memiliki dampak positif atas kinerja karyawan. Kata kunci: gaya kepemimpinan, motivasi kerja, kinerja karyawan  ABSTRACT The influence of leadership style and work motivation on employee performance manufacturing industry in Bogor. To apply these objectives, descriptive analysis methods, validity tests, reliability tests, correlation tests, simple regression, multiple regression, determinant tests, and partial and simultaneous tests are used. Regression obtained that there is a strong effect between leadership style on employee performance variable. A good leadership style will improve employee performance. Motivation has a significant effect on employee performance. The results of the regression analysis obtained that there is a significant (significant) influence on the motivation variable on the employee performance variable. Keywords: corporate social responsibility, entrepreneurship orientation, SME innovation
PENINGKATAN KAPASITAS SDM DAN PEMASARAN DIGITAL DENGAN MEDIASI MODAL INTELEKTUAL TERHADAP KINERJA USAHA AGRIBISNIS
Authors: Wicaksana Indrajit , Budiningsih Susilowati , Triastuti Yuli , Jayadi Jayadi
Published: April 2023

Pandemi covid-19 memberikan dampak besar bagi usaha skala mikro, kecil, dan menengah. Kebijakan pembatasan sosial yang berskala besar akibat covid-19 berdampak pada turunnya aktivitas ekonomi, termasuk di bidang agribisnis. Strategi yang diterapkan untuk penguatan usaha di masa pandemi ini salah satunya adalah memperkuat kapasitas sumber daya manusia agar tetap bertahan dan berinovasi. Penelitian ini ditujukan untuk mengetahui pengaruh langsung dan tidak langsung peningkatan kapasitas sumber daya manusia (capacity building) dan pemasaran digital (digital marketing) terhadap peningkatan kinerja usaha agribisnis di masa pandemi covid-19 melalui mediasi modal intelektual (intellectual capital). Sampel penelitian ini mencakup 50 usaha agribisnis. Melalui penelitian ini akan diketahui pengaruh langsung dan tidak langsung capacity building pada kinerja usaha agribisnis saat covid-19. Kata kunci: agribisnis, kinerja, modal intelektual, pemasaran digital, peningkatan kapasitas ABSTRACT The Covid-19 pandemic has had an impact on micro, small and medium scale businesses. The large-scale social restriction policy due to Covid-19 has had an impact on decreasing economic activity, including in the agribusiness sector. One of the strategies implemented to strengthen business during this pandemic is to strengthen the capacity of human resources to survive and innovate. This study aims to determine the direct and indirect effects of increasing the capacity of human resources and digital marketing on improving the performance of agribusiness businesses during the Covid-19 pandemic through the mediation of intellectual capital. The sample of this research includes 50 agribusiness enterprises. Through this research, it will be known the direct and indirect effects of capacity building on the performance of agribusiness during Covid-19. Keywords: agribusiness, capacity building, digital marketing, intellectual capital, performance
PERAN KEPERCAYAAN DALAM MEMEDIASI PROMOSI ONLINE DAN BRAND IMAGE TERHADAP LOYALITAS MAHASISWA DI JAKARTA
Authors: Herlina Elin , Mulyanto Heru
Published: April 2023

Penelitian ini untuk mengetahui peran kepercayaan dalam memediasi promosi online dan brand image terhadap loyalitas mahasiswa. Penelitian dilakukan pada mahasiswa perguruan tinggi di jakarta. Sampel diambil dengan metode random sampling dengan membagikan kuesioner kepada 87 mahasiswa. Data dari kuesioner dianalisis menggunakan software Smart-PLS. Promosi Online berpengaruh positif terhadap kepercayaan. Brand Image berpengaruh positif terhadap kepercayaan. Kepercayaan berpengaruh positif terhadap loyalitas. Kepercayaan memediasi promosi online secara positif pada loyalitas. Kepercayaan memediasi secara positif brand image pada loyalitas. Berdasarkan temuan tersebut, untuk meningkatkan loyalitas mahasiswa, disarankan agar institusi meningkatkan kepercayaan mahasiswa dengan meningkatkan Promosi Online dan Brand Image. Kata kunci: brand image, kepercayaan, loyalitas, promosi online  ABSTRACT This research is to determine the role of trust in mediating the influence of online promotion and brand image on student loyalty. Research was conducted on students at universities in Jakarta. Samples were taken using the random sampling method by distributing questionnaires to 87 students. Data from the questionnaire was analyzed using smart PLS software. This study resulted in findings that: 1) Online Promotion positively affects trust; 2) Brand Image positively affects trust; 3) Trust positively affects loyalty; 4) Trust mediates online promotion positively on loyalty; 5) Trust positively mediates brand image on loyalty. To increase student loyalty, it is recommended that institutions increase student trust by increasing Online Promotion and Brand Image. Keywords: brand image, loyalty, online promotion, trust.
Treatment of Isolated Intracranial Progression of Lung Cancer During Treatment with Systemic Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs)
Authors: Tufman Amanda , Schrödl Kathrin , Scheithauer Heike , Duell Thomas , Coppenrath Eva , Hube Rudolf Maria
Published: April 2023

Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are an effective treatment for non-small-cell lung cancer (NSCLC) harbouring EGFR mutations. The development of isolated central nervous system (CNS) metastases is a relevant clinical problem in patients who respond well to EGFR-TKIs.
Methods: We present a patient with isolated progression of brain metastases during treatment of EGFRmutated NSCLC with an EGFR-TKI and review the treatment options in this setting, including the evidence for and toxicity of treatment with high-dose TKIs.
Results: Oligometastatic CNS progression during TKI therapy may be treated locally. Both whole brain radiotherapy (WBRT) and stereotactic brain irradiation are well tolerated and effective in this setting. The use of high-dose pulsed TKIs is intended to increase the concentration of TKI in the brain and has been reported to be effective and without significant toxicity in case reports and small case series. These therapeutic options are illustrated in the case of a 44-year-old NSCLC patient who developed CNS progression after WBRT during second-line erlotinib and was treated locally with stereotactic radiosurgery (SRS) and, upon further CNS progression, with high-dose pulsed erlotinib. This resulted in intracerebral response; however, significant haemorrhage also occurred. Severe haemorrhage has not previously been described as a complication of high-dose pulsed erlotinib.
Conclusion: Possible explanations for isolated CNS progression during TKI treatment include inadequate dosing across the blood—brain barrier and longer survival on TKIs. The efficacy and tolerability of high- dose pulsed TKIs for CNS metastases has been previously reported. None of the cases reported showed the severe haemorrhage and cerebral oedema that developed in our patient. Simultaneous anticoagulation as well as previous SRS may have predisposed our patient to haemorrhage and may prove to be relative contraindications to high-dose pulsed erlotinib. Most centres only see a few patients in this clinical situation, and co-operative efforts are needed to collect and analyse similar cases and to develop appropriate treatment strategies.
Alma's (Not) Normal: Normalising Working-Class Women in/on BBC TV Comedy
Authors: Minor Laura
Published: April 2023

This article examines the BBC sitcom Alma's Not Normal and its representation of white working-class femininities in/on British TV comedy. After The Royle Family creator Caroline Aherne's death in July 2017, the BBC created a bursary in memory of the comedy star, awarding £5,000 to the successful applicant to develop a pilot comedy script. Though open to people of all backgrounds and genders, the three winners so far have been working-class women – Sophie Willan, Amy Gledhill and Kiri Pritchard-McLean – an important shift from the recent success of female-fronted and female-authored middle-class comedies on the BBC such as Miranda and Fleabag. This article examines the award's first winner: Boltonian Sophie Willan and her series Alma's Not Normal. While Phil Wickham argues that contemporary working-class sitcoms in Britain display the ‘hidden injuries of class’, something that is felt but no longer acknowledged, I contend that Willan exposes class wounds by explicitly referencing and drawing attention to social issues in her TV series. More specifically, I argue that, as a working-class woman in the North West, Willan uses comedy to interrogate the intersections of class and gender. This textual analysis will then be used as a framework to conceptualise the labour of working-class women in British television comedy, mainly because class has been overlooked as a social category in contemporary scholarship on feminism and humour.
Clinical features and “early” corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia
Authors: Liu Jinrong , He Ruxuan , Zhang Xiaoyan , Zhao Fei , Liu Liyong , Wang Heng , Zhao Shunying
Published: April 2023

Background

Many children with mycoplasma pneumoniae (MP) pneumonia (MPP) developed sequelae such as bronchiolitis/bronchitis obliterans (BO). Early corticosteroid therapy might prevent disease progression. This study aimed to use “early” corticosteroid and observe the treatment outcome in patients with MPP.

Methods

Patients who had pulmonary infiltrations on chest imaging within 5 days of the disease course and were suspected of having MP infection on admission were enrolled. Among them, patients whose disease course was within 10 days on admission were ultimately enrolled. We analyzed their data including the clinical features, the starting time and dose of corticosteroid therapy, and the treatment outcome. According to chest imaging, we divided patients into two groups (Group A: bronchiolitis-associated lesions or ground-glass opacities; Group B: pulmonary segmental/lobar consolidation).

Results

A total of 210 patients with confirmed MPP were ultimately enrolled. There were 59 patients in Group A and 151 patients in Group B. Patients in Group A were more prone to have allergy histories, hypoxemia, wheezing sound, and wet rales on auscultation than those in Group B. Corticosteroid treatment was initiated between 5 and 10 days of disease onset in all patients and 6–7 days in most patients. Methylprednisolone was prescribed in all patients within 10 days of disease onset, and the highest prescribed dose was at least 2 mg/kg/day. In Group A, methylprednisolone >2 mg/kg/day was prescribed in 22 patients, and among them, 8 patients with diffuse bronchiolitis-associated lesions received high-dose methylprednisolone therapy. After 3 months, lung CT revealed slightly segmental ground-glass opacity in three patients. In Group B, methylprednisolone >2 mg/kg/day was prescribed in 76 patients, and among them, 20 patients with pulmonary lobar consolidation received high-dose methylprednisolone therapy. After 3 months, chest imaging revealed incomplete absorption of pulmonary lesions in seven patients. Among them, five patients with consolidation in more than one pulmonary lobe ultimately had slight BO.

Conclusion

In hospitalized patients with MPP, particularly severe MPP, the ideal starting time of corticosteroid treatment might be 5–10 days, preferably 6–7 days, after disease onset. The initial dosage of corticosteroid therapy should be decided according to the severity of the disease. MPP patients with diffuse bronchiolitis-associated lesions/whole lobar consolidation on imaging might require high-dose corticosteroid therapy.