bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Buku Elektronik (E-Book) sebagai Media Pembelajaran Ekstrakurikuler Wajib Pramuka
Authors: Rahmadhani Sutrisza , Supriadi Supriadi , Okra Riri , Efriyanti Liza
Published: July 2023

Penelitian ini dilatarbelakangi tentang persoalan peserta didik yang sering kehilangan buku dan materi pembelajaran pkstrakuerikuler pramuka sehingga kesulitan bagi peserta didik dalam memahami matei. Pengembangan E-book bertujuan memudahkan peserta didik dan pembimbing dalam proses pemahaman pramuka, baik itu pemahaman teori maupun praktek. Penelitian ini menggunakan metode Research and Development (RnD), dan pada tahapan pengembangannya memakai metode waterfall dengan model Pressman. Aplikasi dibangun dengan memakai software sublimetext, photoshop, coreldrar, filmora, dan memakai Bahasa pemrograman HTML dan CSS  sebagai back end dan CSS bootsratp sebagai front end. Produk penelitian ini diuji dengan menggunakan formula rumus Aiken’s “V” untuk uji validitas, Formula Moment kappa untuk mendapatkan hasil uji praktikalitas dan formula Gain Score untuk mendapatkan nilai dari uji efektifitas. Berdasarkan ketiga pengujian yang telah didapatkatkan bahwa produk valid dengan hasil nilai 0.81 dengan kategori valid, hasil uji praktis dengan nilai 0.86 dengan kategeori kepraktisan tinggi, dan nilai efektifitas yaitu sebesar 0,88 dengan katergoi efetifitas sangat tinggi. Produk ini dapat mempermudah peserta didik dalam mengikuti kegiatan ekstrakurikuler pramuka dan dapat memprmudah pembimbing pramuka dalam menjelaskan materi pramuka.

Abstract

This research is motivated by the problem of students who often lose books and scout extracurricular learning materials so that it is difficult for students to understand the material. E-book development aims to facilitate students and supervisors in the process of understanding scouts, both theoretical and practical understanding. This study uses the Research and Development (RnD) method, and at the stage of development it uses the waterfall method with the Pressman model. The application is built using sublimetext, photoshop, coreldrar, filmora software, and uses HTML and CSS programming languages ​​as the back end and CSS bootsratp as the front end. The product of this research was tested using the Aiken's "V" formula to test the validity, the Moment kappa formula to get the results of the practicality test and the Gain Score formula to get the value of the effectiveness test. Based on the three tests that have been obtained, it is found that the product is valid with a value of 0.81 with a valid category, practical test results with a value of 0.86 with a high practicality category, and an effectiveness value of 0.88 with a very high effectiveness category. This product can make it easier for students to participate in scout extracurricular activities and can make it easier for scout supervisors to explain scout material
COUNSELING ON LEARNING ENGLISH WITH THEME OF STRENGTHENING PANCASILA PROFILE TO STUDENTS AT KINDERGARTEN OF AN NUUR, MOJOROTO DISTRICT, KEDIRI CITY
Authors: Yoyok Febrijanto  , Nofa Novera
Published: July 2023

This community service activity aims to improve the teaching skills of kindergarten teachers at Kindergarten of An Nuur, Mojoroto District, Kediri City in terms of learning methods, namely the play pictures method, the story method, and the demonstration method. While the type of counseling that was carried out was an effective way of learning for kindergarten students. The results of this community service activity was that the understanding and ability of kindergarten teachers regarding effective learning methods for kindergarten students can be improved by conducting counseling; teacher's understanding and ability can increase success in learning the subject matter. In addition, understanding parents of kindergarten students about how their children learn and understanding. By understanding the parents of kindergarten students, they have improved how their children learn, understand every subject explained by kindergarten teachers, and not forcing their children to complete homework properly.
ACERCÁNDONOS A CIERTOS CÓMICS Y SEXUALIDADES. DE LA EMANCIPACIÓN SEXUAL A LA INSTITUCIONALIZACIÓN
Authors: Fridman Cristina Tania
Published: July 2023

Ya en los albores de los años 60 Umberto Eco advertía en su ensayo “Apocalípticos e Integrados” que la historieta es un producto cultural, ordenado desde arriba, y funciona según toda la mecánica de la persuasión oculta, presuponiendo en el receptor una postura de evasión que estimula de inmediato las veleidades paternalistas de los organizadores. Y los autores, en su mayoría, se adaptan: así los comics, en su mayoría, reflejan la implícita pedagogía de un sistema y funcionan como refuerzo de los mitos y valores vigentes.
Procedimiento administrativo de denuncias en el delito de agresiones contra la mujer y los integrantes del grupo familiar en la modalidad de violencia Familiar en la PNP, comisaría de Chorrillos, 2021
Authors:   , Barraza Monteverde Julissa Adriana
Published: July 2023

La presente investigación titulada “Procedimiento administrativo de denuncias en el delito de agresiones contra la mujer y los integrantes del grupo familiar en la modalidad de violencia familiar en la PNP, Comisaría de Chorrillos, 2021”, tuvo como objetivo determinar la influencia del procedimiento administrativo de denuncias en el delito de agresiones contra la mujer y los integrantes del grupo familiar en la modalidad de violencia familiar en la PNP, Comisaría de Chorrillos, 2021. El tipo de investigación es no experimental de corte transversal, correlacional-causal y con alcance cuantitativo. La población que se ha considerado es 50 policías, la técnica empleada fue la encuesta y de instrumento con un cuestionario de 20 ítems con 5 alternativas de Likert. En conclusión, podemos decir que la eficacia de la PNP contra la violencia psicológica en contra de las mujeres y el delito de Violencia familiar no se hace evidente en nuestra sociedad, tampoco de manera oportuna, sino más bien que es un problema mayor; por lo que éste presente trabajo tendrá a bien dar a conocer las incidencias sobre el tema y cuál es el nivel de eficacia e intervención de la PNP en cuanto a estos procedimientos Administrativos
La conciliación extrajudicial y su incidencia en la tenencia compartida del menor en la ciudad de Ambo - Huánuco 2021-2022
Authors:   , Leon Cardenas Conzuelo
Published: July 2023

La presente investigación, propone regular en la Ley de Conciliación 26872 la Tenencia Compartida, su procedimiento, el derecho de opinión del menor y a ser escuchado por el conciliador, para garantizar y salvaguardar su bienestar. En la actualidad la mencionada ley, no garantiza la tenencia compartida y el derecho a la libertad de opinión del menor, porque no está regulada en su marco legal, visto que en su artículo 7° únicamente indica que el conciliador deberá aplicar el principio del interés superior, sin indicar pauta alguna, transgrediendo así los derechos y quebrantando el mencionado principio. Asimismo, el objetivo general es la regulación de la Tenencia Compartida en la Ley 26872, su procedimiento y el derecho a la libertad de opinión del menor. Además, la investigación tiene un enfoque cuantitativo, donde se aplicó la encuesta conformada por 18 preguntas, con finalidad de obtener la opinión de mi población y muestra conformada por 35 personas (conciliadores extrajudiciales y padres de familia). Obteniendo como resultados mayoritarios, las opciones que están de acuerdo y totalmente de acuerdo que se implemente en la Ley 26872 la tenencia compartida, su procedimiento y el derecho de opinión. Finalmente concluyo señalando que, es importante que se regule en la Ley de Conciliación 26872 la tenencia compartida, su procedimiento y el derecho de opinión del menor establecido en el Código y en la Convención de los Derechos del Niño, para garantizar y salvaguardar el bienestar del menor.
Finite temperature effects on Dipolar Superfluids
Authors: Mestre Fons Bartolomé , Maucher Fabian
Published: July 2023

We qualitatively discuss the dependency of the phase-transition between a super-
fluid and a supersolid of a dipolar Bose-Einstein condensate confined to a tubular
geometry on temperature employing beyond mean-field corrections.
Estudio de los niveles de IgA frente a Anisakis simplex en sueros de paciente con esclerosis múltipl
Authors: DE LA HOZ MARTIN MARIA PIEDAD , González Fernández Juan
Published: July 2023

Es un estudio en el que se analizan y comparan los niveles séricos de IgA anti-Anisakis en donantes sanos y en pacientes con esclerosis múltiple para observar alguna relación entre los niveles séricos de IgA y el desarrollo de esclerosis múltiple.
Gun Violence Trends in US Cities During the Early Phase of the COVID-19 Pandemic
Authors: Hall Chandler , Wilson Nick , Piquero Alex R.
Published: January 2025

This cross-sectional study evaluates whether there was any variation in gun violence trends in US cities during the early phase of the COVID-19 pandemic.
Medication for Opioid Use Disorder in Federally Qualified Health Centers
Authors: Lindenfeld Zoe , Mauri Amanda I.
Published: January 2025

This cross-sectional study examines changes in and factors associated with rates of patients with substance use disorder receiving medication for opioid use at federally qualified health centers.
Biomarker-Directed Radiotherapy in Breast Cancer
Authors: Meattini Icro , Coles Charlotte E. , Tramm Trine , Borghesi Simona , Krug David , Montero Angel , Nardone Valerio , Salvestrini Viola , Valzano Marianna , Valentini Vincenzo , Aristei Cynthia , Poortmans Philip ,   Assisi Think Tank Meeting Investigators, Arenas Meritxell , Boersma Liesbeth J. , Bolukbasi Yasemin , Ciabattoni Antonella , Franco Pierfrancesco , Genovesi Domenico , Kaidar Person Orit , Kouloulias Vassilis , Krengli Marco , Leonardi Maria Cristina , Lozza Laura , Marazzi Fabio , Masiello Valeria , Morganti Alessio G. , Offersen Birgitte , Palumbo Isabella , Pedretti Sara , Perrucci Elisabetta , Ratosa Ivica , Rivera Sofia , Garcia Trigo Maria de Lurdes
Published: January 2025

Importance

Integration of molecular biomarker information into systemic therapy has become standard practice in breast cancer care. However, its implementation in guiding radiotherapy (RT) is slower. Although postoperative RT is recommended for most patients after breast-conserving surgery and, depending on risk factors, following mastectomy, emerging evidence has indicated that patients with low scores on gene expression signatures or selected clinical-pathological features may have very low local recurrence rates. This narrative review explored the potential of biomarker-directed personalized RT approaches, which may optimize treatment strategies and be associated with improved patient outcomes and experiences.

Observations

Distinctions between prognostic and predictive biomarkers were highlighted, emphasizing the importance of analytical and clinical validity in biomarker-based studies. Findings from studies investigating the prognostic and predictive value of various genomic signatures and immunohistochemical markers for guiding breast RT were presented. These included the Adjuvant Radiotherapy Intensification Classifier and the Profile for the Omission of Local Adjuvant Radiation, which have shown potential in predicting RT benefits. The genomic-adjusted radiation dose and role of tumor-infiltrating lymphocytes were also discussed. Ongoing clinical trials exploring the use of biomarkers in ductal carcinoma in situ and invasive breast cancer to refine RT decision-making were illustrated.

Conclusions and Relevance

The results of this narrative review suggest that evidence-based shared decision-making is crucial to optimize treatment according to the individual’s predicted benefits and risks along with their personal preferences. Incorporation of biomarker-directed approaches in RT for breast cancer may hold promise for personalized treatment, potentially facilitating omission of RT for patients at low risk of recurrence, while identifying those who may benefit from intensified therapy. This personalized RT approach may be associated with improved clinical outcomes and quality of life and facilitate decision-making for people with breast cancer. However, there remains a need for robust clinical and analytical validation of biomarkers to ensure reliability and clinical utility for RT optimization.
Speech Perception in Noise After Cochlear Implantation for Single-Sided Deafness
Authors: van Heteren Jan A. A. , Wendrich Anne W. , Peters Jeroen P. M. , Grolman Wilko , Stokroos Robert J. , Smit Adriana L.
Published: January 2025

Importance

There is a lack of high level of evidence studies comparing the effect of different treatment options for single-sided deafness (SSD).

Objective

To determine the effect of a cochlear implant (CI), bone conduction device (BCD), contralateral routing of signals hearing aid (CROS), and no treatment on speech perception in noise outcomes in patients with SSD.

Design, Setting, and Participants

In this single-center randomized clinical trial, adult patients with SSD were randomized into 3 groups: CI; a trial period with first a BCD on a headband and then a CROS; or a trial period with first a CROS and then a BCD on a headband. After the trial periods, patients opted for a BCD, CROS, or no treatment. Measurements were completed at baseline and at 3, 6, 12, and 24 months of follow-up. Data were collected from July 2014 to October 2021, and data were analyzed from December 2022 to May 2023.

Interventions

CI, BCD then CROS, or CROS then BCD.

Main Outcomes and Measures

The primary outcome was the speech reception threshold in noise (SRTn), measured with speech and noise from the front (S0N0), speech directed to the poor ear and noise to the better ear (SpeNbe), and vice versa (SbeNpe). The secondary outcome was disease-specific quality of life (QOL).

Results

Of 120 included patients, 60 (50.0%) were female, and the mean (SD) age at inclusion was 53.0 (12.1) years. At the start of follow-up, 28 patients received a CI, 25 a BCD, 34 a CROS, and 26 chose no treatment. At 24 months, the CI group had significantly better speech perception in noise scores than the BCD group (difference in SRTn: SbeNpe, −4.7 dB; 95% confidence interval, −6.6 to −3.0; SpeNbe, −2.2 dB; 95% confidence interval, −4.6 to −1.1), the CROS group (difference in SRTn: S0N0, −1.3 dB; 95% confidence interval, −1.7 to −0.2; SbeNpe, −5.3 dB; 95% confidence interval, −6.0 to −3.1), and the no treatment group (difference in SRTn: SpeNbe, −6.3 dB; 95% confidence interval, −7.5 to −4.9). Compared with the no treatment group, the BCD and CROS groups showed significantly better (difference in SRTn for SpeNbe, −4.1 dB [95% confidence interval, −5.2 to −1.5] and −4.1 dB [95% confidence interval, −6.1 to −3.3], respectively) or worse (difference for SbeNpe, 4.0 dB [95% confidence interval, 2.6 to 6.2] and 4.6 dB [95% confidence interval, 2.8 to 5.7], respectively) speech perception in noise. Self-reported speech perception abilities were significantly better for the CI group compared with the BCD, CROS, and no treatment groups.

Conclusions and Relevance

In this randomized clinical trial, the CI group outperformed the BCD, CROS, and no treatment groups in terms of speech perception in noise and disease-specific QOL in patients with SSD after 24 months of follow-up. These results indicate that patients with SSD can partially regain the advantages of binaural hearing after treatment.

Trial Registration

trialregister.nl Identifier: NL4457
Cationic Vacancy Modulation of Mn3O4 as a Superior Cathode for Durable Aqueous Zinc‐Ion Batteries
Authors: Deng Shenzhen , Xu Bingang , Liu Xinlong , Yang Yujue , Xiao Yana , Wang Shuai , Zhao Jingxin , Chen Tiandi
Published: January 2025

Aqueous zinc‐ion batteries (AZIBs) have attracted more and more attention owing to their high safety, low cost, and environmental friendliness. Mn‐based materials are considered as one of the most promising cathode materials for AZIBs because of their high output voltage, eco‐friendliness, and abundance. However, the low electrochemical activity and the manganese dissolution of Mn3O4 lead to the low specific capacity and inferior cycling stability, hindering its practical applications. Herein, a facile and low‐cost strategy is designed that combines cationic vacancy modulation with Mn ion‐confinement effect in a synergistic action to boost zinc ion energy storage capability of inert Mn3O4 (designated as VMn‐Mn3O4@C). The cationic vacancy endows Mn3O4 with more active sites, resulting in an increased specific capacity. Meanwhile, the manganese dissolution is inhibited via the Mn ion‐confinement effect of the carbon framework, thereby improving the cycling stability of the cathode. Consequently, the developed Zn/VMn‐Mn3O4@C batteries deliver a high specific capacity of 280.9 mAh g−1 and 98.4% capacity retention after 100 cycles at 0.1 A g−1. More importantly, VMn‐Mn3O4@C cathodes maintain superior cycling stability of 5000 cycles with nearly 100% capacity retention at 1 A g−1.
Coplanar Pattern and Temperature Transient Control in Intelligent Wearable Multi‐Color Alternating Current Electroluminescence Devices
Authors: Wang Xun , Lin Yuting , Zhang Ying , Xu Shilin , Liu Mingyu , Shen Yaoxi , Gong Yingzhen , Xiong Yarui , Hu Yi
Published: January 2025

Flexible alternating current electroluminescence (ACEL) devices integrated into textiles are gaining significant attention for their potential in lighting displays and health monitoring applications. Traditional challenges include high‐voltage “breakdown” and limited color output due to the inherent properties of ZnS:Cu. This study introduces a novel multi‐color ACEL device featuring a fluorescent dye color conversion layer alongside a robust protective layer designed to enhance device stability. The optimal ratio of dielectric layer concentration and protective layer thickness is systematically investigated to mitigate the risk of “breakdown”. Utilizing the principles of photoluminescence and electroluminescence, luminous electronic textile devices is successfully developed that exhibit both purple and green luminescence. Additionally, integration with a temperature sensor enables the device to serve as a health‐monitoring tool by signaling changes in body temperature. This research delineates the protective capabilities of the protective layer and the efficacy of the color conversion mechanism in maintaining consistent brightness under various conditions. The findings suggest a viable pathway for broadening applications and potentially accelerating the commercialization of wearable electroluminescent technologies.
A Facile Approach To Develop Ion Pair Micelles Satellited Freshly Derived Neutrophils For Targeted Tumor Therapy
Authors: Sharma Garima , Wangpimool Kwanjira , George Joy Jomon , Sharma Ashish Ranjan , Son Hyeon Ki , Kim Songrae , Jeong Hoibin , Kim Jin‐Chul
Published: January 2025

Immune cells show enormous potential for targeted nanoparticle delivery due to their intrinsic tumor‐homing skills. However, the immune cells can internalize the nanoparticles, leading to cellular functional impairments, degradation of the nanoparticles, and delayed release of drugs from the immune cells. To address these issues, this study introduces an approach for the synthesis of freshly derived neutrophils (NUs)‐based nanocarriers system where the NUs are surfaced by dialdehyde alginate‐coated self‐assembled micelles loaded with mitoxantrone (MIT) and indocyanine green (ICG) (i.e., dA(MI@IPM)s) for stimuli‐responsive tumor‐targeted therapy. Here, the dA(MI@IPM)s are not internalized by the NUs, but they are anchored on the membrane of the NUs via distearoylphosphatidylethanolamine‐polyethylene glycol‐polyethylenimine anchors. Owing to the natural recruitment ability of NUs to the tumor microenvironment, NUs‐anchored dA(MI@IPM)s accumulation is higher at the tumor site than free dA(MI@IPM)s, where the dA(MI@IPM)s can readily detach from the NUs to get internalized in the tumor cells. The stimuli‐responsive dA(MI@IPM)s disassembles inside the cancer cells upon near‐infrared irradiation due to the photosensitizing effect of the loaded ICG, releasing MIT and significantly inhibiting tumor growth. This approach is simple and fast to prepare, opening up exciting possibilities for personalized cancer treatment using patient's autologous NUs.
Transition of Perovskite Solar Technologies to Being Flexible
Authors: Castriotta Luigi Angelo , Uddin Md Aslam , Jiao Haoyang , Huang Jinsong
Published: January 2025

Perovskite technologies has taken giant steps on its advances in only a decade time, from fundamental science to device engineering. The possibility to exploit this technology on a thin flexible substrate gives an unbeatable power to weight ratio compares to similar photovoltaic systems, opening new possibilities and new integration concepts, going from building integrated and applied photovoltaics (BIPV, BAPV) to internet of things (IoT). In this perspective, the recent progress of perovskite solar technologies on flexible substrates are summarized, focusing on the challenges that researchers face upon using flexible substrates. A dig into material science is necessary to understand what kind of mechanisms are limiting its efficiency compare to rigid substrates, and which physical mechanism limits the upscaling on flexible substrate. Furthermore, an overview of stability test on flexible modules will be described, suggesting common standard procedure and guidelines to follow, showing additional issues that flexible modules face upon bending, and how to prevent device degradation providing an ad‐hoc encapsulation. Finally, the recent advances of flexible devices in the perovskite market will be shown, giving an outline of how this technology is exploited on flexible substrates, and what are still missing that need stakeholders’ attention.
Recent Progress and Advances of Perovskite Crystallization in Carbon‐Based Printable Mesoscopic Solar Cells
Authors: Xiang Junwei , Han Chuanzhou , Cheng Yanjie , Gao Qiaojiao , Hu Wenjing , Zhou Yang , Mei Anyi , Zhou Yinhua , Han Hongwei
Published: January 2025

Carbon‐based printable mesoscopic solar cells (p‐MPSCs) offer significant advantages for industrialization due to their simple fabrication process, low cost, and scalability. Recently, the certified power conversion efficiency of p‐MPSCs has exceeded 22%, drawing considerable attention from the community. However, the key challenge in improving device performance is achieving uniform and high‐quality perovskite crystallization within the mesoporous structure. This review highlights recent advancements in perovskite crystallization for p‐MPSCs, with an emphasis on controlling crystallization kinetics and regulating perovskite morphology within confined mesopores. It first introduces the p‐MPSCs, offering a solid foundation for understanding their behavior. Additionally, the review summarizes the mechanisms of crystal nucleation and growth, explaining how these processes influence the quality and performance of perovskites. Furthermore, commonly applied strategies for enhancing crystallization quality, such as additive engineering, solvent engineering, evaporation controlling, and post‐treatment techniques, are also explored. Finally, the review proposes several potential suggestions aimed at further refining perovskite crystallization, inspiring continued innovation to address current limitations and advance the development of p‐MPSCs.
Advances in Oxygen Evolution Reaction Electrocatalysts via Direct Oxygen–Oxygen Radical Coupling Pathway
Authors: Rong Chengli , Huang Xinyi , Arandiyan Hamidreza , Shao Zongping , Wang Yuan , Chen Yuan
Published: January 2025

Oxygen evolution reaction (OER) is a cornerstone of various electrochemical energy conversion and storage systems, including water splitting, CO2/N2 reduction, reversible fuel cells, and rechargeable metal‐air batteries. OER typically proceeds through three primary mechanisms: adsorbate evolution mechanism (AEM), lattice oxygen oxidation mechanism (LOM), and oxide path mechanism (OPM). Unlike AEM and LOM, the OPM proceeds via direct oxygen–oxygen radical coupling that can bypass linear scaling relationships of reaction intermediates in AEM and avoid catalyst structural collapse in LOM, thereby enabling enhanced catalytic activity and stability. Despite its unique advantage, electrocatalysts that can drive OER via OPM remain nascent and are increasingly recognized as critical. This review discusses recent advances in OPM‐based OER electrocatalysts. It starts by analyzing three reaction mechanisms that guide the design of electrocatalysts. Then, several types of novel materials, including atomic ensembles, metal oxides, perovskite oxides, and molecular complexes, are highlighted. Afterward, operando characterization techniques used to monitor the dynamic evolution of active sites and reaction intermediates are examined. The review concludes by discussing several research directions to advance OPM‐based OER electrocatalysts toward practical applications.
Shear‐Mediated Stabilization of Spin Spiral Order in Multiferroic NiI2
Authors: Tseng Yi , Occhialini Connor A. , Song Qian , Barone Paolo , Patel Sahaj , Shankar Meghna , Acevedo‐Esteves Raul , Li Jiarui , Nelson Christie , Picozzi Silvia , Sutarto Ronny , Comin Riccardo
Published: January 2025

Type‐II multiferroicity from non‐collinear spin order is recently explored in the van der Waals material NiI2. Despite the importance for improper ferroelectricity, the microscopic mechanism of the helimagnetic order remains poorly understood. Here, the magneto‐structural phases of NiI2 are investigated using resonant magnetic X‐ray scattering (RXS) and X‐ray diffraction. Two competing magnetic phases are identified. Below 60 K, an incommensurate magnetic reflection (q ≈ [0.143,0,1.49] reciprocal lattice units) is observed which exhibits finite circular dichroism in RXS, signaling the inversion symmetry‐breaking helimagnetic ground state. At elevated temperature, in the non‐polar phase (60 K < T < 75 K), a distinct q ≈ [0.087,0.087,1.5] magnetic order is observed, attributed to a collinear incommensurate (CI) state. The first‐order CI‐helix transition is concomitant with a structural transition characterized by a significant interlayer shear, which drives the helimagnetic ground state as evidenced by a mean‐field Heisenberg model including interlayer exchange and its coupling to the structural distortion. These findings identify interlayer magneto‐structural coupling as the key driver behind multiferroicity in NiI2.
A Robust, Biodegradable, and Fire‐Retardant Cellulose Nanofibers‐Based Structural Material Fabricated from Natural Sargassum
Authors: Li De‐Han , Han Zi‐Meng , Shao Meng , Jiao Zhi‐Jin , Gao Chen , Sun Wen‐Bin , Liu Zhao‐Xiang , Yang Kun‐Peng , Guan Qing‐Fang , Yu Shu‐Hong
Published: January 2025

With increasing concern about the environmental pollution of petrochemical plastics, people are constantly exploring environmentally friendly and sustainable alternative materials. Compared with petrochemical materials, cellulose has overwhelming superiority in terms of mechanical properties, thermal properties, cost, and biodegradability. However, the flammability of cellulose hinders its practical application to a certain extent, so improving the fire‐retardant properties of cellulose nanofiber‐based materials has become a research focus. Here, cellulose nanofiber and alginate are extracted from abundant natural sargassum as high‐strength nanoscale building blocks, and then a sargassum cellulose fire‐retardant structural material is prepared through a bottom‐up hydrogel layer‐by‐layer method. The structural materials obtained incorporate excellent mechanical properties (≈297 MPa), thermal stability (≈200 °C), low thermal expansion coefficient (≈7.17 × 10−6 K−1), and fire‐retardant properties. This work largely improves the utilization of seaweed residue and natural polymers, providing a bio‐based fire‐retardant strategy, and has a wide range of development prospects in the field of fiber‐based high‐performance structural materials in the future.
Dynamic Reconstruction of Fluid Interface Manipulated by Fluid Balancing Agent for Scalable Efficient Perovskite Solar Cells
Authors: Sun Kai , Wang Zhen , Li Naizhen , Liu Licheng , Xiong Wei , Xu Zengjie , Geng Zhi , Guo Xiaoyang , Jiang Yue , Feng Shien‐Ping , Gao Xingsen , Chen Yiwang , Liu Junming , Gao Jinwei
Published: January 2025

Laboratory‐scale spin‐coating techniques are widely employed for fabricating small‐size, high‐efficiency perovskite solar cells. However, achieving large‐area, high‐uniformity perovskite films and thus high‐efficiency solar cell devices remain challenging due to the complex fluid dynamics and drying behaviors of perovskite precursor solutions during large‐area fabrication processes. In this work, a high‐quality, pinhole‐free, large‐area FAPbI3 perovskite film is successfully obtained via scalable blade‐coating technology, assisted by a novel bidirectional Marangoni convection strategy. By incorporating methanol (MeOH) as a fluid balance agent, the direction of Marangoni convection is effectively regulated, mitigating the disordered motion of colloidal precursor particles during the printing process. As a result, champion power conversion efficiencies (PCEs) of 24.45% and 20.32% are achieved for small‐area FAPbI3 devices (0.07 cm2) and large‐area modules (21 cm2), respectively. Notably, under steady illumination, the device reached a stabilized PCE of 24.28%. Furthermore, the unencapsulated device exhibited remarkable operational stability, retaining 92.03% of its initial PCE after 1800 h under ambient conditions (35 ± 5% relative humidity, 30 °C). To demonstrate the universality of this strategy, a blue perovskite light‐emitting diode is fabricated, showing an external quantum efficiency (EQE) of 14.78% and an electroluminescence wavelength (EL) of 494 nm. This work provides a significant technique for advancing solution‐processed, industrial‐scale production of high‐quality and stable perovskite films and solar cells.
Formal [3+1+1+1] Annulation of 2‐Isocyanophenyl Propargylic Esters and 4‐Hydroxy‐2H‐Chromen‐2‐Ones: An Access to Quinoline‐Fused Polycyclic Skeletons
Authors: Xing Yu , Li Xiangheng , Ni Zihan , Guo Jiajian , Zhou Zijun , Cui Lei , Li Chunju , Li Jian
Published: January 2025

A cascade reaction involving 2‐isocyanophenyl propargylic ester and 4‐hydroxy‐2H‐chromen‐2‐one has been documented. This reaction leads to the formation of a highly strained cyclopropen‐imine species, thereby offering an efficient route to synthesize quinoline‐fused polycyclic skeletons.
1,3‐Iodoesterification of 2‐Substituted Indoles via Csp2−H/Csp3−H Retained Dual Functionalization Using Hypervalent Iodine(III)
Authors: Wasaki Hiroko , Moriyama Katsuhiko
Published: January 2025

A 1,3‐iodoesterification of 2‐substituted indoles with trihaloacetic acid, iodination reagent, and hypervalent iodine(III) compound was developed as an acid‐promoted Csp2−H/Csp3−H dual functionalization reaction to furnish 3‐iodo‐2‐trihaloacetoxymethyl indoles. The one‐pot 1,3‐iodoesterification/hydrolysis of the trihaloester group provided 3‐iodo‐2‐pivaloylmethyl indoles via the rearrangement of the pivaloyl group. The reaction proceeded through a trihaloacetic acid‐assisted electrophilic activation of the iodination reagent after the formation of an indolyl(mesityl)iodonium trihaloacetate.
Surface‐Functionalized Diatoms as Green Nano‐Adsorbents for the Removal of Methylene Blue and Methyl Orange as Model Dyes from Aqueous Solution
Authors: Ojike Chidinma Akobueze , Hagen Volker , Beszteri Bank , Galstyan Anzhela
Published: January 2025

Water pollution from the chemical industry has become a significant and widespread global environmental problem. This necessitates the development of cost‐effective adsorbents with rapid removal efficiency. In this paper, the use of low‐cost and globally available diatomaceous earth (DE) is decribed as a sorbent for the removal of model dyes, methylene blue (MB) and methyl orange (MO). The skeleton is chemically modified to achieve highly selective sorption and the results are compared with silica (Si)  which has the same functionalities. The adsorption performance of the sorbents obtained is investigated by varying different parameters such as pH value, adsorbent dosage, initial concentration of dye, and contact time. Diatomaceous earth functionalized with carboxyl groups showed a better removal efficiency of MB (up to 100%) than functionalized silica. The removal of MO with functionalized imidazolium species is found to be comparable (up to 70%). The adsorption kinetics are investigated using first and second‐order pseudo‐models, with the latter showing superior agreement with the experimental data. The results demonstrate the potential of biosorbents to enable energy‐efficient water remediation.
Collagen Nanofiber‐Lignin Composite Sponges with Adjustable Hierarchical Pore Structure for Efficient Low‐Frequency Sound Absorption
Authors: Ma Yan , He Mu , Wang Jiaxuan , Ma Fuying , Yu Hongbo , Zhou Yaxian , Xie Shangxian
Published: January 2025

Current sound‐absorbing materials, reliant on nonrenewable resources, pose sustainability and disposal challenges. This study introduces a novel collagen‐lignin sponge (CLS), a renewable biomass‐based material that combines collagen's acoustic properties with lignin's structural benefits. CLSs demonstrate high porosity (>0.97), lightweight (10 mg cm−3), and exceptional broadband noise absorption performance (sound absorption coefficient exceeding 0.9 across 2000–6300 Hz). Due to their unique hierarchical and aligned pore structure, CLSs display superior low‐frequency sound‐absorbing capabilities and a high noise‐reduction coefficient of 0.64 (for a 30‐mm‐thick sample). A geometric model is also developed to evaluate and predict the sound absorption performance with high consistency to the experimental results. Additionally, the inclusion of lignin as a green crosslinker has significantly improved the thermal stability and compressive strength by ≈600% compared to collagen sponges alone. The innovative integration of collagen and lignin in this study not only leverages the benefits of renewable resources but also presents a cost‐effective and straightforward preparation process, positioning CLS as a promising alternative for the construction of sound‐absorbing materials seeking sustainable solutions.
A Peptide‐Derived Aggregation‐Induced Emission Nanobioprobe: Unlocking Selective Detection of Fusobacterium nucleatum and Noninvasive Screening of Colorectal Cancer
Authors: Liu Hongyu , Wu Tengling , Yu Yunjian , Xin Youtao , Lu Hegang , Zhao Shengke , Su Meihui , Ga Lu , Dong Alideertu , Elsabahy Mahmoud , Gao Hui
Published: January 2025

Colorectal cancer (CRC) screening and early diagnosis is an effective strategy for reducing CRC mortality. However, the current detection methods involve exorbitant costs and complex procedures, which are inconvenient for large‐scale screening. Given its high prevalence in malignant tissues and feces of CRC patients, Fusobacterium nucleatum (F. nucleatum) has emerged as a crucial biomarker for the early detection of CRC. Herein, we propose an F. nucleatum‐specific recognition strategy for CRC screening and diagnosis. A novel nanobioprobe (AIE‐Pep) with aggregation‐induced emission (AIE) characteristics was synthesized by conjugating a red/near‐infrared (NIR) emissive AIE luminogen (AIEgen) with a FadA‐targeting peptide (ASANWTIQYND). The robust binding affinity between the peptide and FadA on F. nucleatum allows AIE‐Pep NPs to adhere selectively to F. nucleatum, and emits strong red/NIR fluorescence. In the model of the orthotopic CRC, AIE‐Pep NPs can precisely localize F. nucleatum around CRC. Moreover, AIE‐Pep NPs demonstrated a limit of detection (LOD) of 82.97 CFU/mL for F. nucleatum, which could significantly differentiate the feces of CRC mice from those of normal mice. Overall, this study presents a pivotal approach to specifically identifying F. nucleatum and holds immense potential for CRC diagnosis.
Could Better‐Quality Employment Improve Population Health? Findings From a Scoping Review of Multi‐Dimensional Employment Quality Research and a Proposed Research Direction
Authors: Ahonen Emily Q. , Winkler Megan R. , Bosmans Kim , Gunn Virginia , Julià Mireia
Published: January 2025

Background

Precarious employment, a specific part of the conceptual spectrum of employment quality (EQ), has been established as an important risk to individual and population health and well‐being when compared to a standard employment circumstance. There remains a need, however, to explore whether and how EQ might be used as a tool to not only protect but also advance population health and well‐being.

Methods

The purposes of this scoping review were to assess the analytic treatment of the multiple dimensions of EQ and the stances researchers take to characterize the state of knowledge of EQ that supports the idea that better EQ is a health‐promoting factor. Quantitative, qualitative, and mixed‐methods primary studies that included at least three of the seven conceptually‐informed EQ dimensions were eligible. Studies were assessed for EQ dimensions represented, how dimensions were treated analytically, the pathogenic, ambivalent, or salutogenic stances used by investigators, and what each might tell us about how to leverage aspects of better‐quality employment to improve population health.

Results

A total of 78 studies were included; 54 of these treated EQ dimensions in an interrelated way. Of the analytically interrelated studies, none had an explicit salutogenic stance. Some evidence suggests that a handful of EQ types might present an equal or reduced risk of poor health than the standard employment relationship, frequently used as a historic gold standard.

Conclusion

Research with a salutogenic stance might build our understanding of whether and how employment could be used to advance our collective well‐being.
Stabilizing Contorted Doubly‐Reduced Tetraphenylene with Heavy Alkali Metal Complexation: Crystallographic and Theoretical Evidence
Authors: Zhu Yikun , Zhou Zheng , Wei Zheng , Tsybizova Alexandra , Gershoni‐Poranne Renana , Petrukhina Marina A.
Published: January 2025

The two‐fold reduction of tetrabenzo[a,c,e,g]cyclooctatetraene (TBCOT, or tetraphenylene, 1) with K, Rb, and Cs metals reveals a distinctive core transformation pathway: a newly formed C−C bond converts the central eight‐membered ring into a twisted core with two fused five‐membered rings. This C−C bond of 1.589(3)–1.606(6) Å falls into a single σ‐bond range and generates two perpendicular π‐surfaces with dihedral angles of 110.3(9)°–117.4(1)° in the 1TR2− dianions. As a result, the highly contorted 1TR2− ligand exhibits a “butterfly” shape and could provide different coordination sites for metal‐ion binding. The K‐induced reduction of 1 in THF affords a polymeric product with low solubility, namely [{K+(THF)}2(1TR2−)] (K2‐1TR2−). The use of a secondary ligand facilitates the isolation of discrete complexes with heavy alkali metals, [Rb+(18‐crown‐6)]2[1TR2−] (Rb2‐1TR2−) and [Cs+(18‐crown‐6)]2[1TR2−] (Cs2‐1TR2−). Both internal and external coordination are observed in K2‐1TR2−, while the bulky 18‐crown‐6 ligand only allows external metal binding in Rb2‐1TR2− and Cs2‐1TR2−. The reversibility of the two‐fold reduction and bond rearrangement is demonstrated by NMR spectroscopy. Computational analysis shows that the heavier alkali metals enable effective charge transfer from the 1TR2−TBCOT dianion, however, the aromaticity of the polycyclic ligand remains largely unaffected.
Evaluation of Annual Storage on Online Released Compounds in Artemisia argyi Smoke With GC‐MS‐Based Untargeted Metabolomics Coupled With Chemometric Method of AntDAS‐GCMS
Authors: Zhai Meng , Liu Jia‐Nan , Wang Long‐He , Wen Yan‐Jin , Ma Hui , Liu Ping‐Ping , Chai Guo‐Bi , Zhang Qi‐Dong , Ma Ji , Yu Yong‐Jie
Published: January 2025

Artemisia argyi smoke, generated from the combustion of A. argyi, is widely utilized in traditional Chinese medicine for moxibustion and fumigation therapies. The released smoke during the combustion of A. argyi is rich in massive compounds and can be affected by storing periods. However, there is a lack of a comprehensive understanding on the chemical composition of released smoke, and the effects of annual storage on the released smoke were still unclear. Herein, a strategy that integrated chromatography–mass spectrometry (GC‐MS) with advanced chemometric software, AntDAS‐GCMS, was developed for comprehensively characterizing tens of compound in the released smoke of A. argyi and evaluating the quality variation across annual storage periods. Both particle and gas phases of the released smoke during the combustion were collected for GC‐MS analysis; the raw data files were then imported to our recently developed data analysis software AntDAS‐GCMS for automatically retrieving underlying components. Components that show significant difference among annual storage periods were screened to provide a total of 471 components. Finally, 61 compounds were identified. Both supervised and unsupervised chemometric methods suggest that the 2‐ and 4‐year storage periods were close to clinic used sample (3‐year storage), whereas a too short storage (like 1 year) or too long storage (6 years) were quite different from the 3‐year storage samples. In conclusion, this strategy provides a novel solution for evaluating smoke samples from traditional Chinese medicine.
Rapid and low‐temperature synthesis of MoAlB MAB phase by using stress‐induced Al‐particles
Authors: Dey Maharshi , Tran Quan , Zhang Jin , Ngige Godswill , Javaid Sabah , Pantoya Michelle , Gupta Surojit
Published: January 2025

Currently, MoAlB particles are produced at 1000°C and higher temperatures. In this manuscript, we report the rapid synthesis of MoAlB by altering the stress of Al particles to affect Al reactivity. The Al particles were purposefully stress‐altered to reduce their threshold for reaction. The stress‐altering process consisted of annealing followed by quenching of the aluminum powder. The combined process caused a reaction at a lower temperature between Mo, B, and Al to form MoAlB. The stress‐altering of Al particles (i.e., Al [TT‐treated]) was effective in producing >95 wt.% MoAlB after reaction at only 700°C for 10 min, a significant reduction in temperature. Based on these results, we can further project that this process can be used for manufacturing Al‐based compositions at significantly lower temperatures.
On‐Demand Continuous Flow Synthesis of Pentafluorosulfanyl Chloride (SF5Cl) Using a Custom‐Made Stirring Packed‐Bed Reactor
Authors: Peyrical Lauriane C. , Mabit Thibaud , Kairouz Vanessa , Charette André B.
Published: January 2025

The pentafluorosulfanyl (SF5−) group has been the subject of a surge of interest in the past decade, but there is still little practicality associated with its synthesis and installation. Herein is reported the first continuous flow synthesis of pentafluorosulfanyl chloride (SF5Cl), the most common reagent for the synthesis of SF5‐substituted compounds. The synthesis is based on inexpensive and easy‐to‐handle reagents: sulfur powder (S8), trichloroisocyanuric acid (TCCA) and potassium fluoride (KF). To this end, a custom‐made stirring reactor was designed to allow for fast, safe, and highly efficient on‐demand synthesis of SF5Cl. The resulting SF5Cl solution is showcased in the radical addition on alkynes in a telescoped fashion.
Upgrade of Weak σ‐hole Bond Donors via Cr(CO)3 Complexation
Authors: Dhaka Arun , Beccaria Roberta , Pizzi Andrea , Tupikina Elena Yu. , Kukushkin Vadim Yu. , Resnati Giuseppe
Published: January 2025

Molecular recognition mediated by s‐hole interactions is enhanced as the electrostatic potential at the σ‐hole becomes increasingly positive. Traditional methods to strengthen σ‐hole donor ability of atoms such as halogens often involve covalent modifications, such as, introducing electron‐withdrawing substituents (neutral or positively charged) or electrochemical oxidation. Metal coordination, a relatively underexplored approach, offers a promising alternative. In this study, η6‐coordination of Cr(CO)3 to haloarenes, a neutral system, is demonstrated to significantly increase the electrophilic character of halogen bond donors, enabling weak donors such as chloroanisole to form short and directional Cl···O halogen bonds. Structural characterization using single‐crystal X‐ray diffraction and computational analysis of a series of η6‐Cr(CO)3‐coordinated haloarenes provides evidence for this enhancement. Furthermore, the effect is shown to extend to other heteroatomic substituents on the coordinated arene, e.g., other halogen atoms as well as elements of groups 16, 15, and 14 of the periodic table, broadening the scope of this approach.
Oligoethylene Phosphoramidate‐Based Kinase Inhibitor Prodrugs – Solubility, Enzyme Inhibition, and Hydrolysis
Authors: Spiewok Sarah , Schaefer Maximilian , Lamla Markus , Jaritz Yannick , Kuehne Alexander J. C.
Published: January 2025

The efficiency of kinase inhibiting cancer therapeutics is often limited by their poor solubility in water. PEGylation is one possible strategy to improve the solubility of the drug, however, means to cleave off the PEG after reaching the target is important to make use of the therapeutic effects of the native drug. Moreover, the length of the PEG chains will have an effect on the solubility and binding. In this study, we want to extend our understanding of solubilizing oligo ethylene glycol (OEG) chains connected to kinase inhibitors using a pH labile phosphoramidate linker. We synthesize a library of drug‐OEG conjugates for Ceritinib, Crizotinib, Palbociclib, and Ribocilib kinase inhibitors with n=2, 3, 4 and 8 OEG repeat units. We study the influence on water solubility, enzyme inhibition, and pH induced hydrolysis. A maximum in solubility is obtained for n=3 or 4. We show that small differences in chain length can strongly influence the water solubility, while all other properties remain relatively comparable.
Resorcinol‐based Bolaamphiphilic Quaternary Ammonium Compounds
Authors: Asante Johanna Y. D. , Casey Caroline M. , Bezold Elise L. , Fernando Asantha , McDonough Diana , Wuest William M. , Minbiole Kevin P. C.
Published: January 2025

Quaternary ammonium compounds (QACs) play crucial disinfectant roles in healthcare, industry, and domestic settings. Most commercially utilized QACs like benzalkonium chloride have a common architectural theme, leading to a rise in bacterial resistance and urgent need for novel structural classes. Some potent QACs such as chlorhexidine (CHX) and octenidine (OCT) feature a bolaamphiphilic architecture, comprised of two cationic centers at the molecular periphery and a non‐polar region connecting them; these compounds show promise to elude bacterial resistance mechanisms. Inspired by such structures, we synthesized a series of 43 biscationic amphiphilic compounds focused on a resorcinol core, featuring flexibility of linker lengths, alkyl tails, and relative substituent positioning, to study their structure activity relationships (SARs). Antibacterial activity evaluation against a panel of gram‐positive and gram‐negative strains, including ESKAPE pathogens (A. baumannii, P. aeruginosa), were encouraging, with minimum inhibitory concentrations (MICs) of 0.5–4 μM against all tested strains for select compounds. Ten prepared compounds bearing either 17 or 18 total side chain carbons demonstrated uniformly strong antibacterial activity against P. aeruginosa (MIC 4–16 μM) and 6 other strains (MIC ≤4 μM), irrespective of cationic spacing. These findings promise to further extend the application of bolaamphiphilic QACs as a novel class of disinfectants.