bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between Adversity Intelligence and Career Adaptability in Students of the Department of Industrial Technology Vocational School Diponegoro University Third Year
Authors: Pertiwi Rahma Zahidah , Sawitri Dian Ratna
Published: June 2023

This study aims to determine the relationship between adversity intelligence and career adaptability in students of the Department of Industrial Technology, Vocational School, Diponegoro University in Semarang, Central Java. The study population was 423 students of the Department of Industrial Technology of the Vocational School of Diponegoro University, and a sample of 204 people were taken using convenience sampling techniques. Measuring instruments used were the Adversity intelligence scale (39 items, α = 0.931) and the Career Adaptability scale (40 items, α = 0.952). Spearman Rank non-parametric correlation analysis shows that there is a significant positive relationship between adversity intelligence and career adaptability in students of the Department of Industrial Technology Vocational School of Diponegoro University, with a correlation coefficient of rxy = 0.702 (p <0.05). The higher adversity intelligence, the higher the career adaptability they have.
Hubungan antara Penyesuaian Diri dengan Motivasi Berprestasi pada Siswa Kelas X di SMA Negeri 1 Kudus dengan Sistem Pembelajaran Full Day School
Authors: Ulfia Rista Titania , Rusmawati Diana
Published: June 2023

Full day school merupakan sistem pembelajaran sehari penuh selama 5 hari dalam semingu. Diterapkannya sistem ini membuat para siswa kesulitan dalam menjalani pembelajaran di sekolah. Banyak siswa yang merasa tertekan sehingga membuat siswa enggan untuk menjalankan tanggungjawabnya dengan cara yang terbaik agar mencapai keberhasilan di sekolah. Penelitian ini bertujuan untuk mengetahui hubungan antara penyesuaian diri dengan motivasi berprestasi pada siswa kelas X di SMA Negeri 1 Kudus dengan pembelajaran full day school. Populasi dalam penelitian ini adalah siswa kelas X di SMA Negeri 1 Kudus yang berjumlah 388 siswa. Sampel penelitian terdiri dari 188 siswa yang diperoleh dengan menggunakan teknik cluster random sampling. Metode pengumpulan data yang digunakan dalam penelitian ini adalah skala model likert, diantaranya yaitu Skala Penyesuaian Diri (32 aitem, α = 0,890) dan Skala Motivasi Berprestasi (29 aitem, α = 0,884). Hasil pengolahan data menggunakan analisis regresi sederhana memperoleh nilai koefisiensi korelasi rxy = 0,780 dengan p = 0,000 (p<0,05). Hasil tesebut menunjukkan bahwa terdapat hubungan positif yang signifikan antara penyesuaian diri dengan motivasi berprestasi pada siswa kelas X di SMA Negeri 1 Kudus. Artinya, semakin tinggi penyesuaian diri siswa, maka semakin tinggi pula motivasi berprestasi siswa. Penyesuaian diri memberikan sumbangan efektif sebesar 60,8%  pada motivasi berprestasi.
HUBUNGAN ANTARA KECERDASAN SPIRITUAL DENGAN KEMATANGAN KARIER PADA SISWA KELAS XI SMA NEGERI 1 KOTA MUNGKID
Authors: Kistina Qorin Yuda , - Diana Rusmawati
Published: June 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara kecerdasan spiritual dengan kematangan karier pada siswa Kelas XI SMA Negeri 1 Kota Mungkid. Populasi dalam penelitian ini berjumlah 341 siswa dengan subjek penelitian sebanyak 252 siswa. Teknik pengambilan sampel yang digunakan adalah teknik cluster random sampling. Alat ukur yang digunakan adalah Skala Kecerdasan Spiritual (54 aitem; α = 0,936) dan Skala Kematangan Karier (31 aitem; α = 0,903). Analisis Rank Spearman menunjukkan bahwa terdapat hubungan positif yang signifikan antara kecerdasan spiritual dengan kematangan karier pada siswa Kelas XI SMA Negeri 1 Kota Mungkid (ρ= 0,629; p = 0,000). Artinya semakin tinggi kecerdasan spiritual maka semakin tinggi pula kematangan karier siswa. Begitu pula sebaliknya, semakin rendah kecerdasan spiritual maka semakin rendah pula kematangan karier siswa.
PENYUSUNAN MODUL PELATIHAN GRATITUDE UNTUK MENINGKATKAN RESILIENSI PADA WARGA BINAAN PEREMPUAN DI LEMBAGA PEMASYARAKATAN PEREMPUAN KELAS IIA SEMARANG
Authors: Nurwendah Riris , Kaloeti Dian Veronika Sakti
Published: June 2023

Penelitian ini bertujuan untuk menyusun modul pelatihan gratitude untuk meningkatkan resiliensi pada warga binaan perempuan di Lembaga Pemasyarakatan Perempuan Kelas IIA Semarang berdasarkan sepuluh langkah melatih gratitude. Metode yang digunakan adalah Research and Development (R&D). Modul pelatihan telah melalui validasi oleh psikolog menggunakan kuesioner dan uji coba kepada kelompok kecil warga binaan perempuan. Data dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa modul pelatihan gratitude layak digunakan berdasarkan validasi psikolog dan perlu dilakukan adanya uji coba lanjutan kepada kelompok lebih luas pada warga binaan perempuan guna melihat efektivitas modul pelatihan gratitude.
Hubungan Antara Pola Asuh Otoriter Dengan Pengambilan Keputusan Karier Pada Siswa Kelas XII SMK Hidayah Semarang
Authors: Gradiyanto Gerri , Indrawati Endang Sri
Published: June 2023

Masa pendidikan Sekolah Menengah Kejuruan (SMK) adalah pengambilan keputusan yang banyak terkait dengan masa depan. Masalah pengambilan keputusan yang karier adalah mengembangkan pengetahuan tentang pekerjaan dunia dan berdasarkan minat untuk mengasah kemampuan. Salah satu faktor yang berpengaruh dalam mengambil keputusan bagi siswa adalah keluarga. Orang tua memiliki pola asuh yang berbeda-beda, salah satunya adalah pola asuh otoriter. Pola asuh otoriter merupakan pola asuh yang diberikan orang tua kepada anak yang dipersepsikan mengekang, menuntut, dan membatasi anak. Penelitian ini bertujuan untuk melihat hubungan antara pola asuh otoriter dengan pengambilan keputusan karier siswa SMK.Populasi penelitian ini yaitu seluruh siswa kelas XII SMK Hidayah Semarang yang mungkin 142 siswa. Subjek pengambilan menggunakan teknik cluster random sampling . Pengumpulan data menggunakan Skala Pola Asuh Otoriter (30 aitem valid dengan α = 0,913) dan Skala Pengambilan Keputusan Karier (25 aitem valid dengan α = 0,920). Analisis data menggunakan metode analisis statistik regresi sederhana menunjukkan adanya hubungan negatif yang signifikan antara pola asuh otoriter dengan pengambilan keputusan karier pada siswa kelas XII SMK Hidayah Semarang (rxy = -0,345; p = 0,000). Pola asuh otoriter memberikan sumbangan efektif sebesar 11,9% terhadap pengambilan keputusan karier.
STUDI FENOMENOLOGI : PROSES MEMBANGUN KEPERCAYAAN DIRI PADA PENYANDANG TUNADAKSA DEWASA AWAL AKIBAT KECELAKAAN
Authors: Ningtyas Amalia Puja , Indriana Yeniar
Published: June 2023

Penelitian ini bertujuan untuk menemukan makna dan gambaran mengenai dinamika psikologis seorang tuna daksa dewasa awal akibat kecelakaan dalam membangun kepercayaan diri. Subjek dalam penelitian berjumlah tiga orang yang mengalami ketunadaksaan akibat kecelakaan dan memiliki status belum menikah. Teknik yang digunakan dalam pencarian subjek adalah purposive sampling dimana sampel dipilih berdasarkan karakteristik penelitian (Patton, 2009). Teknik analisis data yang digunakan dalam penelitian yaitu Interpretative Phenomenological Analysis (IPA) yang berfokus pada pengalaman subjek melalui kehidupan pribadi dengan menggunakan wawancara semi terstruktur sebagai metode pengumpulan data. Hasil penelitian menunjukkan bahwa dalam membangun kepercayaan diri ketiga subjek melalui proses dan tahapan yang berbeda-beda sehingga akan berpengaruh terhadap kualitas hidup setiap individu. Hal ini juga dipengaruhi oleh faktor internal (seperti, inferior, kurang percaya diri, tidak berdaya, dan lainnya) serta faktor eksternal (seperti dukungan keluarga, stigma dan diskriminasi lingkungan, dan lainnya).
Pengaruh Hipnoterapi Terhadap Penurunan Tingkat Kecemasan (Anxiety) Akibat Pandemi Covid-19 Di Kota Makassar
Authors: Sahdani Andi Mahdi
Published: June 2023

Anxiety is one of the psychological impacts felt by individuals in the face of the Covid-19 pandemic. Anxiety due to the Covid-19 pandemic arises because of the stimulus related to the Covid-19 pandemic that is received by individuals. Stimulus related to the Covid-19 pandemic that is not processed properly in the cognitive realm causes anxiety and has the potential to reduce individual immunity. Individuals who experience decreased body immunity are susceptible to contracting various diseases, including Covid-19. This study aims to determine the effect of hypnotherapy intervention on reducing anxiety levels due to the Covid-19 pandemic. This research design uses a quasi-experimental research design with one group pretest-posttest research design. Participants in the study consisted of 8 women aged 21-30 years who experienced anxiety due to the Covid-19 pandemic. The measuring instrument used in this study is the Coronavirus Anxiety Scale (CAS) which has been adapted into Indonesian. The data analysis technique used the Wilcoxon test. The results showed that hypnotherapy had an effect on reducing anxiety levels due to the Covid-19 pandemic ( pretest=7.375,  posttest=0.875, ρ=0.007). The implication of this research is that hypnotherapy can be used as an alternative method to reduce anxiety levels due to the Covid-19 pandemic.
HUBUNGAN ANTARA SOCIAL MEDIA ENGAGEMENT DENGAN BODY-ESTEEM PADA SISWI SMAN 1 SALATIGA PENGGUNA INSTAGRAM
Authors: Syafani Hanifa Silvi Azri , Alfaruqy Muhammad Zulfa
Published: June 2023

Penelitian ini bertujuan untuk melihat hubungan antara social media engagement dengan body-esteem pada remaja perempuan pengguna Instagram. Desain penelitian ini menggunakan kuantitatif korelasi. Media penggalian data menggunakan skala cetak yang disebar kepada responden, yaitu siswa perempuan di SMA Negeri 1 Salatiga berusia 14-18 tahun. Partisipan penelitian berjumlah 247 siswa yang ditentukan dengan stratified cluster sampling. Alat ukur yang digunakan adalah skala social media engagement pada platform Instagram (n = 33, α = 0,925) dan skala body-esteem (n = 32, α = 0,935). Hasil analisis Kendall’s tau-b menunjukkan adanya hubungan signifikan antara social media engagement dan body-esteem, dengan indikasi arah hubungan negatif (𝜏b = -0,098, p < 0,05). Dapat disimpulkan bahwa terdapat hubungan yang signifikan dengan arah negatif antara social media engagement dan body-esteem pada siswa perempuan SMA Negeri 1 Salatiga pengguna Instagram. Berdasarkan hasil penelitian, maka rekomendasi yang diberikan adalah sekolah perlu mengadakan kegiatan yang membuat para siswa lebih aktif berinteraksi di dunia nyata dan mengurangi tingkat social media engagement yang berlebihan dalam diri para siswa.
Hubungan antara Regulasi Emosi dengan Stres Pengasuhan pada Ibu dengan Anak Disabilitas Intelektual di Kabupaten Blora
Authors: Putri Aprilia Kusuma , Rusmawati Diana , Dewi Endah Kumala
Published: June 2023

Stres pengasuhan merupakan suatu ketegangan dan kecemasan akibat ketidakmampuan orangtua dalam mengasuh anak, sehingga akan mempengaruhi proses pengasuhan. Kemampuan mengelola emosi negatif ketika mengalami stres pengasuhan dapat membantu proses pengasuhan anak berjalan dengan baik. Penelitian ini dilakukan dengan tujuan untuk mengetahui hubungan antara regulasi emosi dengan stres pengasuhan pada ibu dengan anak disabilitas intelektual di Kabupaten Blora. Sampel pada penelitian sebanyak 49 orangtua yang memiliki anak disabilitas intelektual. Sampel diambil dengan menggunakan metode purposive sampling. Pengumpulan data dilakukan dengan menggunakan dua skala Likert, yaitu skala regulasi emosi (16 aitem; α=0,838 ) dan skala stres pengasuhan (14 aitem; α=0,872). Hasil analisis data regresi linier sederhana menunjukkan bahwa adanya hubungan negatif antara variabel regulasi emosi dengan stres pengasuhan orangtua anak disabilitas intelektual di Kabupaten Blora (rxy = -0,438; p=0,002). Semakin tinggi nilai regulasi emosi, maka akan semakin rendah stres pengasuhan dan sebaliknya, semakin rendah nilai regulasi emosi, maka nilai stres pengasuhan akan semakin rendah.
Manajemen Anestesi pada Pasien Geriatri dengan Abses dan Nyeri Perut Bagian Bawah
Authors: Jatmiko Heru Dwi , Mochamat Mochamat
Published: June 2023

Latar Belakang: Abses abdomen merupakan kondisi yang sering ditemui pada sebagian besar kasus namun merupakan kondisi serius yang membutuhkan pengangan yang tepat dari dokter. Penegakkan diagnosis dan etiologi dari abses abdomen memberikan sebuah tantangan dan peningkatan risiko cedera pada intervensi operasi dan komplikasi post operasi yang diperparah dengan komorbiditas, seperti geriatri. Pada laporan kasus ini, kami bertujuan untuk menjabarkan penanganan anestesi pada pasien geriatri dengan abses abdomen yang menjalani laparotomi.Kasus: Laki – laki berusia 79 tahun datang ke rumah sakit dengan dengan nyeri perut kemudian diketahui memiliki abses abdomen. Terdapat keluhan kelemahan anggota tubuh sisi kanan. Kelemahan dirasakan baik di ekstremitas atas dan bawah sisi kanan pasien. Pada pemeriksaan fisik, pasien tampak sadar penuh dengan tensi 128/56 mmHg, laju jantung 57x / menit, laju pernapasan 20x/menit, berat badan 52 kg dan tinggi badan 160 cm. Pemeriksaan dari head to toe, konjungtiva anemis (+/+), mulut bisa membuka 3 jari (kategori Mallampati 2), tidak ada gigi palsu, gigi ompong, maupun gigi goyang. Pada pemeriksaan lab, diperoleh hasil gula darah sewaktu 122 mg/dL, ureum 43 mg/dL, kreatinin 1,0 mg/dL, natrium 133 mmol/L, kalium 4,0 mmol/L, klorida 101 mmol/L, SGOT 18 IU/L, SGPT 16 IU/L. Pasien kemudian direncanakan untuk dilakukan operasi laparotomi dengan anestesi umum. Pasien menjalani puasa selama 6 jam pre-anestesi, yang kemudian dilanjutkan dengan pemberian pre-medikasi deksametason 5 mg IV. Anestesi awal dilakukan dengan propofol 100 mg, atracurium 30 mg, dan fentanil 50 µg. Untuk anestesi rumatan diberikan sevofluran MAC 2%. Setelah operasi, pasien diberikan ketorolak 30 mg/8 jam IV, parasetamol oral 1000 mg/8 jam, ondansetron 6 mg, dan metoclopramide 10 mg/8 jam IV.Diskusi: Pada laporan kasus ini, dilaporakan sebuah kasus seorang pasien yang datang dengan nyeri perut kemudian diketahui memiliki abses abdomen. Pasien geriatri ini kemudian menjalani laparotomi yang dilakukan dengan anestesi umum untuk mempermudah kontrol ventilasi, serta mencegah gangguan pernapasan dan kardiovaskular selama operasi.Kesimpulan: Pada kasus pasien geriatri dengan nyeri abdomen akibat abses, pemeriksaan fisik secara menyeluruh menjadi dasar untuk memberikan tatalaksana operatif dengan penggunaan anestesi yang adekuat.
How to integrate cultural and geological heritage? The case of the Comuniterrae project (Sesia Val Grande UNESCO Global Geopark, northern Italy)
Authors: Bollati Irene Maria , Caironi Valeria , Gallo Alessio , Muccignato Eliana , Pelfini Manuela , Bagnati Tullio
Published: June 2023

Geoheritage is recognized as a component of the cultural heritage, especially in areas like UNESCO Global Geoparks. In the Sesia Val Grande UNESCO Global Geopark (northern Italy), the “Comuniterrae project” is a participated project focusing on the elaboration of Community Maps of the Middle Lands and including 10 municipalities located in a “mid” territory between the valley bottom and the highlands. Local communities have inventoried 270 elements, both immaterial and material, as components of their cultural heritage. These sites show a strong link with the geological and geomorphological background. We aimed at enlightening this link by selecting the most iconic geo-cultural sites. An original procedure of classification based on 3 main criteria was set on 70 selected sites: i) the kind of geofeatures; ii) the spatial relation between geofeatures and cultural sites, and the reciprocal conditioning; iii) the relation between humans and geofeatures. The results highlight that heritage stones and natural landforms, especially if conditioning the cultural site location, are the most recurrent categories. The use of geofeatures by humans is the most common kind of relation. These results invite to organize meetings with local populations to discuss these outcomes, and to enrich the touristic offer with multidisciplinary approaches.
Screening of the best time window for MSC transplantation to treat acute myocardial infarction with SDF-1α antibody-loaded targeted ultrasonic microbubbles: An in vivo study in miniswine
Authors: Yang Lingjie , Hu Rong , Yuan Chen , Guan Lina , Mu Yuming
Published: June 2023

The present study aimed to screen the best time window for the transplantation of bone marrow mesenchymal stem cells (MSCs) after acute myocardial infarction (MI) through targeted ultrasound microbubbles loaded with SDF-1α antibody. Thirty-six MI miniswine were randomly divided into six experimental groups according to the duration after infarction (1 day, 3 days, 1 week, 2 weeks, 3 weeks, and 4 weeks after infarction). MSCs were labeled with BrdU and then injected through the coronary artery in the stem cell transplantation group to detect the number of transplanted MSCs at different time points after MI. Three miniswine were randomly selected as the control group (sham operation: open chest without ligation of the coronary artery). All SDF-1α groups and control groups were injected with a targeted microbubble ultrasound contrast agent. The values of the myocardial perfusion parameters (A, β, and A × β) were determined. A
T, β
T, and (A × β)T varied with time and peaked 1 week after MI (P < 0.05). The number of transplanted stem cells in the myocardium through coronary injection of MSCs at 1 week was the greatest and consistent with the changing tendency of A
T, β
T, and (A × β)T (r = 0.658, 0.778, 0.777, P < 0.05). β
T(X), (A × β)T(X), and the number of transplanted stem cells was used to establish the regression equation as follows: Y = 36.11 + 17.601X; Y = 50.023 + 3.348X (R

2
= 0.605, 0.604, P < 0.05). The best time window for transplanting stem cells was 1 week after MI. The myocardial perfusion parameters of the SDF-1α targeted contrast agent can be used to predict the number of transplanted stem cells in the myocardial tissue.
Application of dynamic mode decomposition and compatible window-wise dynamic mode decomposition in deciphering COVID-19 dynamics of India
Authors: Rana Kanav Singh , Kumari Nitu
Published: June 2023

The COVID-19 pandemic recently caused a huge impact on India, not only in terms of health but also in terms of economy. Understanding the spatio-temporal patterns of the disease spread is crucial for controlling the outbreak. In this study, we apply the compatible window-wise dynamic mode decomposition (CwDMD) and dynamic mode decomposition (DMD) techniques to the COVID-19 data of India to model the spatial-temporal patterns of the epidemic. We preprocess the COVID-19 data into weekly time-series at the state-level and apply both the CwDMD and DMD methods to decompose the data into a set of spatial-temporal modes. We identify the key modes that capture the dominant features of the COVID-19 spread in India and analyze their phase, magnitude, and frequency relationships to extract the temporal and spatial patterns. By incorporating rank truncation in each window, we have achieved greater control over the system’s output, leading to better results. Our results reveal that the COVID-19 outbreak in India is driven by a complex interplay of regional, demographic, and environmental factors. We identify several key modes that capture the patterns of disease spread in different regions and over time, including seasonal fluctuations, demographic trends, and localized outbreaks. Overall, our study provides valuable insights into the patterns of the COVID-19 outbreak in India using both CwDMD and DMD methods. These findings can help public health organizations to develop more effective strategies for controlling the spread of the pandemic. The CwDMD and DMD methods can be applied to other countries to identify the unique drivers of the outbreak and develop effective control strategies.
Understanding Economic Sanctions on Iran: A Survey
Authors: Farzanegan Mohammad Reza , Batmanghelidj Esfandyar
Published: June 2023

This paper surveys the literature on the economic effects of sanctions on Iran, with a principal focus on those imposed after 2006. We discuss the challenges of isolating the impacts of sanctions and evaluate recent methodological approaches used to measure causal effects. Specifically, we focus on the application of the synthetic control method to disaggregate the exogenous and endogenous factors responsible for economic underperformance in Iran. We review studies on the macroeconomic impacts of Iran sanctions and examine those that focus on the sectoral effects of sanctions. Our survey reveals a large and growing body of literature that remains incomplete. There are significant gaps in the existing research on the impact of sanctions. Iran will likely remain the most important case study as researchers seek to fill those gaps.
Assessment of antibody titer and side effects after fourth doses of COVID-19 mRNA vaccination in 38 healthy volunteers
Authors: Kozakai Rikei , Suzuki Susumu , Sato Yuri , Takahashi Mizue , Chida Nodoka , Takahashi Mei , Hoshi Kuniko , Takahashi Shinichiro
Published: June 2023

Objectives

Fourth dose of SARS-CoV-2 vaccination was started from the end of May, 2022 in Japan. However, data on the precise analysis of the side effects after fourth vaccination, remain scarce. Here, we examined the side effects and the levels of SARS-CoV-2 antibody titers in healthy volunteers who underwent BNT162b2 vaccination for the fourth time.

Methods

Thirty-eight volunteers were assessed for the side effects of the vaccination for the fourth dose, and samples were used for the measurement of SARS-CoV-2 IgG and IgM antibody with chemiluminescent assays.

Results

We found that the level of IgG at day 504 (average, 117.9 AU/mL [SD 76.9]), was significantly higher than at day 264 (average, 17.3 AU/mL [SD 13.1]), which are 8 months after the third and second vaccination, respectively. The level of IgG was potently increased after fourth vaccination (average, 711.8 AU/mL [SD 361.9]), whereas IgM remained baseline level. Commonly reported side effects in the participants after the fourth dose were similar to those until third dose, such as sore arm/pain (81.0 %), generalized weakness/fatigue (57.1 %) and fever (54.8 %). The number of side effects were significantly decreased with age, and participant with sore arm/pain had higher IgG titer (p=0.0007), whereas participant with lymphadenopathy had lower IgG (p=0.0371).

Conclusions

The level of IgG was significantly higher in 8 months after the third, compared to the second, vaccination, and it was potently increased after fourth vaccination. The number of side effects were inversely correlated with age. Sore arm/pain and lymphadenopathy may affect IgG titer.
Development and validation of a nomogram for predicting survival in patients with pancreatic ductal adenocarcinoma after radical pancreatoduodenectomy
Authors: Wang Yanwei , Cui Chenghao , Yu Qiang , Li Mingtai , Liang Yurong
Published: June 2023

Objectives

Hypercoagulation and malnutrition are the characteristic pathophysiological changes associated with pancreatic ductal adenocarcinoma (PDAC), which are intimately related to cancer progression and prognosis. We aimed to integrate related indicators to build a nomogram model to predict the overall survival (OS) of PDAC patients underwent radical pancreatoduodenectomy (PD).

Methods

Clinicopathological and survival data of 138 patients were retrospectively analyzed according to inclusion and exclusion criteria. A nomogram was built based on the multivariate Cox regression analysis. The receiver operating characteristic curve (ROC) and calibration curves were performed based on the bootstrap method to evaluate the predictive performance of the nomogram. Decision curve analysis (DCA) was performed to assess the clinical usefulness of the nomogram.

Results

High-grade tumor (Hazard ratio [HR]: 3.70; 95% confidence interval [CI]: 1.51–3.82; p<0.001), vessel carcinoma embolus (HR: 2.69; 95% CI: 1.30–5.31, p=0.007), N2 (HR: 2.90; 95% CI: 1.47–7.37; p=0.004), anemia (HR: 1.98; 95% CI: 1.01–2.70; p=0.047), PLR>244.8 (HR: 2.13; 95% CI: 1.05–3.45; p=0.033), FBG>3.50 g/L (HR: 2.10; 95% CI: 1.04–3.09, p=0.008), and DRR>1.1 (HR: 2.69; 95% CI: 1.56–4.27; p<0.001) served as independent risk factors for poor OS of patients with PDAC underwent radical PD and were implemented to construct a nomogram. The area under curve (AUCs) for the first, second, and third years were 0.713, 0.777, and 0.845, respectively. Besides, calibration curves fitted well to the ideal line. DCA shows that the nomogram has greater net benefit than the existing TNM staging system, suggesting that this model is a more practical clinical tool for predicting the prognosis of PDAC patients.

Conclusions

The nomogram we established based on the characteristic pathophysiological alterations of PDAC for predicting OS in patients who underwent radical pancreatoduodenectomy presented considerable predictive power. It may facilitate prognostic risk stratification and optimize therapeutic decision-making.
Hypoxia-inducible factor 1α (HIF-1α)-activated Gli1 induces invasion and EMT by H3K4 methylation in glioma cells
Authors: Lin Yihai , Wu Zhangyi
Published: June 2023

Objectives

Gliomas are highly aggressive neuroepithelial-layer malignancies. Hypoxia-inducible factor 1α (HIF-1α) was revealed to be upregulated in gliomas under hypoxia. Nevertheless, its role in glioma cells remains elusive. We attempted to clarify the molecular mechanism of HIF-1 underlying glioma.

Methods

Cellular models were established to mimic the characteristics of hypoxia. RT‒qPCR was used to detect HIF-1α and Gli1 levels in glioma cells with or without hypoxic treatment. Transwell assays were used to measure the invasive ability of U87 and U251 cells. Western blotting was used to evaluate epithelial-mesenchymal transition (EMT)-associated protein abundance and H3K4 methylation (H3K4me)-associated protein abundance in U87 and U251 cells. ChIP assessed the association of HIF-1α or H3K4me with the Gli1 promoter in glioma cells.

Results

HIF-1α and Gli1 were upregulated in glioma cells relative to normal human astrocytes (NHAs). HIF-1α and Gli1 were also upregulated in hypoxia-treated glioma cells relative to untreated glioma cells. Both HIF-1α and Gli1 silencing suppressed glioma invasion and EMT under hypoxia. HIF-1α upregulated Gli1 transcriptionally via MLL1-mediated H3K4me. H3K4me mutation silencing was further demonstrated to suppress glioma cell invasion and EMT under hypoxia.

Conclusions

Both HIF-1α and Gli1 are upregulated in glioma cells and function as oncogenes in glioma cells. HIF-1α transcriptionally activates Gli1 via MLL1-mediated H3K4 methylation in glioma cells, providing ideas for seeking new therapeutic directions for glioma.
SET domain containing protein 8 (SET8) promotes tumour progression and indicates poor prognosis in patients with laryngeal squamous cell carcinoma
Authors: Lan Li-Li , Liu Sheng-Hui , Fan Zhi-Tao , Wang Xue-Xia , Wang Jing-Tian , Wang Ke-Xin , Zhao Rui-Li
Published: June 2023

Objectives

SET Domain Containing Protein 8 (SET8), a member of the SET domain containing methyltransferase family involved in several biological processes and SET8 expression levels, reportedly affects the outcomes of patients with breast cancer, renal cancer, prostate carcinoma, and oesophageal squamous cell carcinoma. However, there have been no relevant studies on the biofunction and use of SET8 expression in the prediction of laryngeal squamous cell carcinoma (LSCC) outcomes.

Methods

In our study, SET8 expression levels were detected using immunohistochemical staining, western blotting, and quantitative real-time RT-PCR (qRT-PCR) with semi-quantitative analysis for laryngeal cancer outcomes. Additionally, we assessed the influence of SET8 on the behaviour of laryngeal cancer cells in vitro, using cell counting kit-8, clone formation, wound healing, and Transwell invasion assays. We subsequently performed qRT-PCR and western blotting for an in-depth study of SET8.

Results

Our study showed marked upregulation of SET8 in tumour tissues and laryngeal cancer cell lines. High SET8 expression predicts poor prognosis in patients with LSCC, and its expression can be used as an independent predictor of LSCC outcome. Subsequent functional analyses indicated that SET8 knockdown exerted an inhibitory effect on proliferation, migration, and invasiveness in vitro.

Conclusions

SET8 may be associated with epithelial-mesenchymal transition. Our results demonstrate that higher SET8 expression is an unfavourable prognostic predictor and exerts tumour-promoting effects in LSCC.
What motivates critical care nurses to stay in their job? A scoping review protocol
Authors: Teutsch Dagmar , Frick Eckhard , Kubitza Jenny
Published: June 2023

Objective

The aim of this scoping review (Registration https://doi.org/10.17605/OSF.IO/28NKU) is to understand the extrinsic and intrinsic factors that motivate critical care nurses to stay in their job.

Introduction

Previous reviews failed to consider both critical care nurses who stay in their job as well as other critical care nurses who have already left the job or switched from critical care to another medical discipline. Moreover, the literature mainly discusses extrinsic factors that lead to job attrition and turnover, but misses out to exemplify intrinsic factors and to put both in relation to one another.

Inclusion criteria

The inclusion criteria will be described by applying the PCC-framework (Population, Context, Concept). The population is limited to fully qualified critical care nurses who currently work or have been working in the field of critical and emergency care. The context is defined within critical care (intensive care units and emergency care in hospitals). Other contexts (e. g., common surgical wards, palliative care) are excluded. The concept is the personal motivation concerning professional engagement.

Methods

Eleven databases and grey literature from 2015–2023 will be searched. We will apply a two-stage screening process by at least two independent reviewers. First, titles and abstracts will be scanned. In a further step, relevant articles will receive a full-text review. Finally, the research team (approx. 5–6 persons) will discuss the extracted data independently.

Ethics and Dissemination

Ethical approval is not required for scoping reviews. Dissemination will include submission to peer-reviewed journals and presentations in conferences and workshops in the area of critical care.
Estimators of tissue absorption parameters power-law prefactor and power-law exponent from medical ultrasonic images
Authors: Brandner Dinah Maria , Zagar Bernhard G.
Published: June 2023

Ultrasound is a mechanical wave propagating in tissue which is influenced in its propagation behavior by the locally prevailing acousto-mechanical conditions. By suitable processing of the back-scattered signals received by the ultrasound transducer, tissue parameters such as local bulk modulus, mass density, speed of sound, isotropic scattering coefficient, and also the locally acting tissue absorption can be inferred. A discipline that has received increasing attention in the medical ultrasonic imaging discipline and its scientific publications in recent years is quantitative ultrasound (QUS) which tries to estimate with great accuracy these local acting tissue parameters. In this paper we analyze different algorithms for estimation of high spatial resolution tissue absorption parameters. On the one hand, there is a simple absorption estimator based on the evaluation of the quotient of the power density spectra calculated for different depth regions (spectral-log-difference estimator), which, however, assumes a linearly with frequency increasing absorption, this is contrasted with an estimator which also allows to estimate a polynomial increase of the absorption with frequency (method-of-moments estimator). Since a closed-form solution cannot be given for this, a maximum-likelihood estimator for which there is always an estimate that can be computed numerically efficiently is developed. The results, tissue attenuation, are presented as a color-coded overlay on conventional B-mode ultrasound images showing only morphology.
Über die Assoziation von Namen mit privaten Empfindungen – ein Kommentar zu Wittgensteins Privatsprachenargument (PU 256 – 265)
Authors: Lüdeking Matthias
Published: June 2023

On the Association of Names with Private Sensations – A Commentary on Wittgenstein’s Private Language Argument (PI 256 – 265). This commentary on PI 256 – 265, informed by Wittgenstein’s Nachlass and the recently published Skinner dictations, shows that Wittgenstein uses a particular method in these sections: He investigates what kind of meaning one might give to the parts of a philosophical sentence. Wittgenstein recommended this method already in TLP and BBB – it marks a continuity in his thought. The sentence under investigation is the following: “And now I simply associate names with sensations” (PI 2009: 256). PI 257 – 265 discuss three proposals of what it might mean to associate a name with a private sensation. PI 257 investigates the claim that the association is set up by means of inventing a name, PI 258 proposes that it consists in a private ostensive definition, and PI 262, 263 suggest that it works by (inwardly) resolving to call this like that. All of these ideas turn out to be unsatisfactory. The reason why PI 258’s private ostensive definition fails is that for a private sensation there is by definition no difference between “it is the same” and “he recognized it”. This is why one cannot talk of recognition here, and therefore the private ostensive definition is an empty ceremony. The result of PI 256 – 265 is not a proof of the impossibility of a private language, but these sections show that the meaning of “And now I simply associate names with sensations” cannot satisfactorily be explained by means of the three aforementioned proposals.
Die Baumstruktur des Tractatus: Genesis, Lesarten, Editionen
Authors: Stern David
Published: June 2023

Tree-Structured Readings of the

Tractatus

: I argue that the numbering system of the Tractatus lets us see how it was constructed, in two closely related senses of that term. First, it tells us a great deal about the genesis of the book, for the numbering system was used to assemble and rearrange a series of drafts, as recorded in MS 104. Second, it helps us understand the structure of the published book, as cryptically summarized in the opening footnote. I also discuss an unpublished letter from Anscombe to von Wright from 1948 which contains the very first sketch of a tree-structured reading, and what I believe is Stenius’s response to Anscombe’s proposal. The paper critically evaluates previous work on tree-structured readings and contends that we need to read the Tractatus in both the number order used in the published book and the tree order that Wittgenstein used to draft it. It also considers some of the main ways of turning this complex branching structure into a linear, printed text, and so serves as an introduction to the three tree-structured editions of the Tractatus that accompany the original English-language publication of this paper in NWR 11 (the German text, and the translations by Ogden & Ramsey and Pears & McGuinness).
Supervisores do PIBID: Contribuições para a formação de futuros professores de Matemática
Authors: GUIMARÃES ENDERSON LOPES , ROLKOUSKI EMERSON
Published: June 2023

Este artigo tem como objetivo compreender as percepções de supervisores do Programa Interinstitucional de Bolsas de Iniciação a Docência - PIBID sobre suas contribuições para a formação de futuros professores de Matemática. Para cumprir com tal objetivo foram constituídos dados advindos de respostas a 55 questionários respondidos por professores supervisores de diversas regiões do Brasil e 5 entrevistas. Os dados assim constituídos foram submetidos à Análise Textual Discursiva emergindo quatro categorias: Supervisor como modelo, Supervisor como apresentador da realidade escolar, Supervisor como orientador de atividades escolares, Supervisor como participante e orientador de atividades acadêmicas. Espera-se que os resultados aqui alcançados contribuam para a formulação de novas políticas públicas de formação de professores, bem como o constante aprimoramento das já existentes.
O papel da língua de sinais e de docentes Surdas na construção de identidades de crianças Surdas
Authors: Romário Lucas , Dorziat Ana
Published: June 2023

Este artigo discute o papel da língua de sinais e de professoras surdas em processos educacionais que envolvem crianças surdas de escolas públicas de Ensino Fundamental de João Pessoa-PB, Brasil. Com base nos Estudos Culturais, nos Estudos Surdos e na abordagem qualitativa realizamos observações de situações pedagógicas e entrevistas semiestruturadas com professoras surdas, atuantes no Atendimento Educacional Especializado (AEE), para obtenção dos dados. As análises mostraram que a língua de sinais e o papel das professoras surdas nos processos educacionais têm grande representatividade na construção identitária das crianças surdas, pelo fato de contribuírem para o seu desenvolvimento educacional, pessoal e social, enfim, de cidadania.
Agronegócio e Educação: o trabalho docente e a pedagogia da hegemonia
Authors: Lamosa Rodrigo de Azevedo Cruz
Published: June 2023

A Associação Brasileira do Agronegócio (ABAG), entidade nacional fundada em Brasília, em 1993, realiza o Programa Educacional Agronegócio na Escola, desde 2001, nas escolas públicas. O objetivo do artigo foi analisar o papel dos professores no projeto de hegemonia da associação. Foi utilizada como procedimentos de coleta de dados a revisão de literatura e entrevistas com dezessete docentes. Concluímos que a ABAG assumiu a tarefa histórica de “Partido do Agronegócio”, articulando na sociedade civil a formação de uma dupla camada de intelectuais orgânicos e a difusão da autoimagem associada à responsabilidade socioambiental. Os professores das escolas públicas vêm sendo assimilados para o papel da difusão de uma autoimagem do agronegócio.
Legislação educacional para o cárcere
Authors: Xavier Antônio Roberto , Laurindo Wedyla Silva , Fiuza Fialho Lia Machado
Published: June 2023

O sistema penitenciário brasileiro não tem conseguido alcançar, de maneira satisfatória, a ressocialização de pessoas privadas de liberdade. Nesse âmbito, a educação surge como uma perspectiva ressocializadora dos apenados. Tal iniciativa constitui-se como um dilema paradoxal nas prisões brasileiras. Este estudo objetiva discutir sobre as garantias que os presos possuem, amparadas nos textos normativos brasileiros, para receber educação no âmbito do sistema penitenciário. Constata-se que há diversos dispositivos legais que asseguram a educação nas prisões, no entanto a carência de boa gestão para tornar eficaz a oferta de uma educação de qualidade acarreta distanciamento entre as normas e sua execução. Esse paradoxo distancia o preso de uma vida cidadã.
Plano Educacional Individualizado para Estudantes com Autismo: uma análise conceitual
Authors: Costa Daniel da Silva , Schmidt Carlo
Published: June 2023

O Plano Educacional Individualizado (PEI) é um instrumento norteador da inclusão de alunos com deficiências, utilizado em diversos países. Trata-se de uma proposta pedagógica compartilhada de ações entre gestores, professores, profissionais especializados e pais, para a aprendizagem do aluno. Estudantes com autismo parecem ser especialmente beneficiados pelo PEI devido ao potencial adaptativo deste instrumento para atender a heterogeneidade dos perfis de aprendizagem da síndrome. O objetivo deste estudo é apresentar uma análise conceitual do PEI, compreendendo suas bases legais e concepções teóricas, aproximações e divergências de outras formas de plano, para discutir as possibilidades de suporte que este instrumento pode oferecer à aprendizagem. Conclui-se que o PEI pode preencher uma lacuna na inclusão por se constituir como uma metodologia de trabalho que endereça as particularidades do ensino destes estudantes por meio do trabalho colaborativo entre a equipe escolar.
Tiempo, individuo y aprendizaje: Tres categorias para repensar la educación como práctica
Authors: Rubio-Gaviria David Andrés , Heredia-Duarte Maria Isabel
Published: June 2023

El artículo se propone realizar un aporte a los debates sobre práctica educativa. Asumiremos tal propósito a partir de tres categorias poco usuales, como lo son tiempo, individuo y aprendizaje. Se plantea como hipótesis que el protagonismo sobre el aprendizaje - que trae aparejado el ascenso del individuo sobre la sociedad - ha estimulado la dilación o, incluso, la detención de la historia, que podemos presentar como tiempo histórico de la educación. Esto de igual manera influye sobre la complejidad de expresarnos sobre la educación como práctica para los tiempos actuales, pues asumir que la educación se reduce a la práctica tiene implicaciones sobre su naturaleza teleológica. Para tales fines, hemos revisado algunas obras de la filosofia moderna del siglo XVIII, además de los aportes de la historia del siglo XX y la crítica que ofrece la antropologia contemporánea.
Da inclusão digital ao digital que inclui
Authors: Saraiva Karla , Loureiro Carine Bueira
Published: June 2023

O objetivo deste artigo é discutir as transformações das possibilidades de acesso à rede mundial de computadores, problematizando os modos de inserção na galáxia internet. A partir de uma retomada das políticas de promoção da inclusão digital, em especial no campo educacional, mostra-se que a apropriação dos meios digitais vem-se realizando com muito maior sucesso através de outras estratégias. Esta apropriação vem ampliando rapidamente a base de usuários, permitindo acesso a processos de ativismo político que passam pelo uso de ferramentas digitais, particularmente, as redes sociais. Neste sentido, o artigo defende que estaríamos passando de uma ênfase nas políticas de inclusão digital para um uso das tecnologias digitais que inclui nos processos políticos de constituição do mundo.
A biblioteca como um espaço de acolhimento, inclusão e promoção da diversidade
Authors: Nogueira Gabriela Medeiros , Vahl Mônica Maciel , Willis Arlette Ingran
Published: June 2023

Este trabalho apresenta resultados de uma pesquisa sobre ações de incentivo à leitura propostas em bibliotecas públicas municipais em dois países: Estados Unidos e Nova Zelândia. Refletimos sobre o papel que esses locais têm em construir uma sociedade culturalmente inclusiva, considerando dois eixos: i) espaço, tempo e ambiente; ii) público, ações e recorrência. A pesquisa, de cunho documental, é pautada na perspectiva de Cellard (2010). A análise dos dados segue os pressupostos de Giardinelli (2010); Patte (2012); Petit (2016); Colomer (2007) e Hirschman (2009). Os dados da pesquisa sugerem que é possível implementar práticas de incentivo à leitura visando o acolhimento das pessoas e a inclusão da comunidade. Para tanto, é necessário políticas públicas consistentes e sistemáticas que fomentem o encontro e o diálogo nas bibliotecas.
O centenário de Paulo Freire e a recontextualização da Educação Popular: possibilidades de uma pedagogia situada
Authors: Pereira Thiago Ingrassia
Published: June 2023

No contexto comemorativo do centenário de nascimento de Paulo Freire, torna-se interessante retomar sua obra no sentido de leituras capazes de nos subsidiar ações educativas na atualidade. O tema desse trabalho é a Educação Popular pensada em perspectiva e em seus diferentes contextos históricos, com enfoque sobre o cenário dos anos 1990 e o debate teórico sobre sua refundamentação ou revivificação, bem como as novas demandas políticas e epistemológicas, com desdobramentos teórico-conceituais, observadas a partir do ambiente político brasileiro depois de 2016. Por meio de pesquisa bibliográfica, revisita-se autores(as) de referência no campo e se sustenta o argumento de que a atualidade de práticas de Educação Popular responde à ofensiva conversadora vigente no Brasil, reafirmando o projeto social contra as opressões e as desigualdades sociais. A recontextualização discutida sugere sua atualidade na construção de “redes de indignação e esperança” a partir de uma prática pedagógica situada.
Cien años con Paulo Freire: esperanza, utopía y transformación
Authors: Battestin Cláudia , Gárate Vergara Francisco , Weyh Cênio Back
Published: June 2023

El presente escrito contribuye para la re-construcción del pensamiento de Paulo Freire, como maestro y educador que, a través de su obra, va destacando su visión de mundo desde la educación. Muestra los procesos que dan origen a la opresión en torno al sistema capitalista y como desde la esperanza pedagógica se forja la transformación de la sociedad. Siempre con una metodología de formación, trabajo con, desde y para el sujeto histórico desde un plano didáctico dialéctico. Por otra parte, indicamos el sentido y proximidad con la educación popular y su desarrollo con los movimientos sociales, sentido y provocación de esta, en su génesis y contexto. Por último, en a re-invención del legado de Paulo Freire, construimos sueños y utopías, marcados por los desafíos de la educación del presente y del futuro.
Centenário de nascimento de Paulo Freire: um legado de fraternuras e de auto(trans)formação com as gentes e o mundo
Authors: Henz Celso Ilgo , Da Silveira Melissa Noal
Published: June 2023

No ano em que se comemora o centenário de Paulo Freire, 1921-2021, seu legado torna-se cada vez mais imprescindível tanto para o mundo da educação como para os mundos que anseiam pela busca humanizadora de gentes em constante auto(trans)formação. Re-conhecer a história desse autor, suas mobilizações e práxis nas fraternuras com as gentes e o mundo é o que nos move nesta escrita e nos convoca para celebrar a vida daquele que é o maior educador de todos os tempos não só do Brasil, mas do mundo. O menino/homem Paulo Freire convoca-nos para ser mais, não negando nossas condições convida-nos à vida, reconhecendo e assumindo o que vimos sendo socio-historicamente. Suas andarilhagens constituíram-se num compromisso do anúncio abundante em defesa de vida digna, testemunhando que pela e na educação nos tornamos mais gente.
Central hyperthyroidism combined with Graves' disease: case series and review of the literature
Authors: Mo Caiyan , Chen Han , Zhang Qi , Guo Ying , Zhong Liyong
Published: June 2023

Background

Central hyperthyroidism is characterized by elevated free thyroid hormone and unsuppressed thyroid-stimulating hormone (TSH), and this laboratory feature includes TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone β (RTHβ). Central hyperthyroidism combined with Graves’ disease (GD) has been rarely reported.

Case Report

We describe three patients with TSHoma combined with GD and one patient with GD combined with RTHβ and pituitary adenoma. These three patients with TSHoma combined with GD showed elevated thyroid hormone, while TSH level was normal or elevated, and TSH receptor antibodies were positive. After thyrotoxicosis was controlled, they all underwent transsphenoidal surgery. We also describe a patient with an initial presentation of GD who developed hypothyroidism after anti-hyperthyroidism treatment and TSH was inappropriately significantly increased. His head magnetic resonance imaging revealed a pituitary adenoma. Genetic testing confirmed a heterozygous mutation in the thyroid hormone receptor β gene c.1148G>A (p.R383H). After levothyroxine and desiccated thyroid tablet treatment, the TSH level decreased to normal.

Conclusion

These four cases highlight the need to consider the diagnosis of GD combined with central hyperthyroidism when faced with inconsistent thyroid function test results, illuminating the specific diagnostic and therapeutic challenges of coexisting primary and central hyperthyroidism. Finally, we propose clinical management for central hyperthyroidism combined with GD.