bluuebunny/crossref_metadata_2025 huggingface dataset:
Tổng quan chi phí - hiệu quả của thuốc Lenvatinib trong điều trị ung thư biểu mô tế bào gan
Authors: Bích Đỗ Thị Ngọc , Bình Nguyễn Huy , Kiệt Phạm Huy Tuấn
Published: June 2023

Ung thư biểu mô tế bào gan có gánh nặng bệnh tật và kinh tế ngày càng tăng, đặc biệt với nhóm bệnh nhân giai đoạn tiến triển hoặc không thể phẫu thuật. Lenvatinib là thuốc điều trị giúp tăng thời gian sống và làm chậm sự tiến triển của bệnh tương đương so với Sorafenib cho nhóm bệnh nhân trên, nhưng chi phí cao khiến người bệnh gặp nhiều khó khăn. Nghiên cứu tổng quan một số tài liệu về chi phí - hiệu quả của Lenvatinib so với các lựa chọn khác trong điều trị ung thư biểu mô tế bào gan dựa trên các cơ sở dữ liệu PubMed, Cochrane, Web of Science, Hinari được thực hiện và công bố đến tháng 12/2022. Ghi nhận 7/9 nghiên cứu Lenvatinib đạt chi phí - hiệu quả tại nhiều nước, tuy nhiên 2 nghiên cứu ở Trung Quốc cho thấy những lựa chọn khác được ưu tiên hơn do giá thành cao của Lenvatinib. Như vậy, việc giảm giá thuốc thấp hơn so với ngưỡng sẵn sàng chi trả của từng nước là cơ hội để người bệnh có khả năng tiếp cận và gia tăng hiệu quả về chi phí. Từ đó xem xét đưa Lenvatinib vào Danh mục thuốc Bảo hiểm y tế.
Teater med barn og unge – kunsterisk virksomhet eller sosialt tiltak? Om prosjekt bydelsteater i Trondheim
Authors: Hanssen Einar
Published: June 2023

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Å overse et barn. Om lek og samhandling i den flerkulturelle barnehagen
Authors: Evenstad Randi
Published: June 2023

Er barn så flinke til å kommunisere på tvers av språk og kulturer at de finner lekekamerater og etablerer vennskap på egen hånd bare fordi de er sammen? Eller trengs det bevisst innsats fra de voksne? Høgskolelektorene Kari Jorde og Randi Evenstad fra Høgskolen i Oslo, har vært i hver sin barnehage for å undersøke lek som arena for samhandling mellom barn fra ulike kulturer. Resultatene viser at det er nødvendig å synliggjøre hva som kreves av barnehagens ledere og av det øvrige personalet, for at intensjonene om kontakt og inkludering skal kunne realiseres. Ellers kan det være fare for at enkelte barn blir oversett.
Physicochemical, microbiological, and sensory evaluation of kefir produced from goat milk containing Lacticaseibacillus casei AP and/or oat milk during storage
Authors: WULANSARI Putri Dian , WIDODO Widodo , SUNARTI Sunarti , NURLIYANI Nurliyani
Published: June 2023

This study combined the probiotic properties of Lacticaseibacillus casei AP with the prebiotic properties of oats to improve kefir products. Lacticaseibacillus casei AP, oat milk, or both were added to goat milk kefir. Physicochemical properties, microbiological evaluation, and sensory evaluation were done over the course of 14 days. The result showed that adding Lacticaseibacillus casei AP and oat milk together had positive (non-opposing) effects on the physicochemical, microbiological, and sensory properties of the kefir product until the end of shelf life. Compared to the control group, the viscosity of kefir increased by two times (13,630 vs. 6,716 mPa). The viscosity of goat milk that had been mixed with Lacticaseibacillus casei AP and oat milk and stored for 14 days also got thicker by 44%. Overall, Lacticaseibacillus casei AP and oat milk can be added to kefir simultaneously over time to improve its qualities.
Okul Psikolojik Danışmanlarının Beceri Boşluğu: Ulusal Meslek Standardı Kapsamında Bir İnceleme
Authors: YILMAZ Olcay , ATAY Bünyamin
Published: June 2023

Bir çok eğitsel ve mesleki alanda yeterliklerin belirlenmesi, ölçülmesi ve buna bağlı gerçekleştirilen yeterlik temelli eğitimler giderek önem kazanmaktadır. Okul psikolojik danışmanları açısından bu kapsamda, Okul psikolojik danışmanı standartları 2017 yılında Resmi Gazete’de “Okul Psikolojik Danışmanı Seviye 7 Ulusal Meslek Standartları” adı altında yayımlanmıştır. Ancak teorik olarak belirlenen bu standartların uygulamada varlığını sorgulayan bir çalışma henüz yoktur. Bu çalışmanın amacı, Ulusal Meslek Standartları’nda yer alan becerilerin okul psikolojik danışmanlarınca ne derece önemli görüldüğünün, bu becerilere ne derece sahip olduklarının ve verdikleri önem ile sahip olma dereceleri arasındaki farkın araştırılmasıdır. Çalışmaya çeşitli kademelerde çalışan 253 psikolojik danışman katılmıştır. Veriler, demografik bilgi formu ve Okul Psikolojik Danışmanlığı UMS Yeterlik Kontrol Listesi aracılığıyla toplanmıştır. En çok önemli ve en yetkin görülen becerilerin çocukluk ve ergenlik dönemi yaşantılarına yönelik beceriler, en az önemli ve en az yetkin görülen becerilerin ise ölçme değerlendirme ve iş ortamına dair beceriler olduğu görülmüştür. Son olarak, tüm becerilerde psikolojik danışmanların becerilere sahip olma dereceleri, becerilere verdikleri önemden istatistiksel olarak anlamlı derecede (p< .05) düşük bulunmuştur. Başka bir deyişle katılımcılar ilgili becerilerin tümünü önemli görmekle birlikte kendilerini bu önemden daha düşük bir yeterlik düzeyinde algılamaktadırlar. Araştırma bulguları, yeterlik temelli lisans ve meslek içi eğitim ihtiyacına işaret etmektedir.
Uzaktan Eğitime Yönelik Tutum, Mesleki Motivasyon Ve Örgütsel İletişim İklimi: COVID -19 Pandemisi Ve Öğretmenler
Authors: KARADEMİR Lütfullah , DEMİRDAĞ Seyithan
Published: June 2023

COVID-19 salgını sebebiyle dünyada 188 ülkede en az 1,5 milyar öğrenci etkilenmiştir. Bu çalışmanın amacı pandemi sürecinde uzaktan eğitim, mesleki motivasyon ve örgütsel iletişim iklimi arasındaki ilişkiyi incelemektir. İlişkisel tarama modelinin kullanıldığı bu nicel çalışmada 400 öğretmen katılımcı olarak yer almıştır. Katılımcıların seçiminde seçkisiz olmayan (non-random) örnekleme yöntemlerinden uygun örnekleme kullanılmıştır. Araştırmanın verileri “Uzaktan Eğitim Tutum Ölçeği”, “Mesleki Motivasyon Ölçeği” ve “Örgütsel İletişim İklimi Ölçeği” ile elde edilmiştir. Çalışmada toplanan verilerin değerlendirilmesinde yüzde, frekans, ortalama ve standart sapma analizleri kullanılmıştır. Çalışmadaki veriler normal bir dağılım gösterdiği için parametrik testler kullanılmıştır. Değişkenler arasındaki ilişkiler Pearson momentler çarpımı korelasyon analizi ile belirlenmiştir. Değişkenlerden birinin diğeri üzerindeki yordama gücünün tespiti amacıyla çoklu regresyon analizi kullanılmıştır. Bulgulara göre uzaktan eğitim genel puanına ilişkin algıların çoğunlukla “katılmıyorum” düzeyinde olduğu bulunmuştur. Çalışmada ayrıca mesleki motivasyon ile örgütsel iletişim iklimi algısı arasında pozitif yönde, orta düzeyde, anlamlı bir ilişki bulunduğu tespit edilmiştir. Son olarak, mesleki motivasyonun, örgütsel iletişim ikliminin anlamlı bir yordayıcısı olduğu bulunmuştur.
Ses ve Özellikleri ile İlgili Tasarım Temelli Etkinliklerin 6. Sınıf Ögrencilerinin Başarı ve Tutumlarına Etkisi
Authors: AKSOY Şeyma , ÖZCAN Hasan , ÇEKEN Ramazan
Published: June 2023

Bu çalışmanın amacı “Ses ve Özellikleri” ünitesi ile ilgili tasarım temelli etkinliklerin altıncı sınıf öğrencilerin bilgi ve tutum düzeylerine etkisini belirlemek, Fen Bilimleri dersinin tasarım temelli fen eğitimi uygulamalarıyla işlenmesi hakkında öğrencilerin bakış açılarını incelemektir. Çalışmada karma yöntem araştırmalarından olan gömülü desen kullanılmıştır. Araştırma sürecinde nitel araştırma uygulamalarından durum çalışması ve nicel araştırma uygulamalarından tek gruplu ön test-son test deneysel desenden faydalanılmıştır. Çalışma grubu bir devlet okulunun altıncı sınıf düzeyinde öğrenim görmekte olan 24 öğrenciden oluşmaktadır. Yarı yapılandırılmış görüşme formu, öğrenci günlüğü ve tasarım temelli fen eğitimi uygulama modülleri ile toplanan notlar ve çizimler nitel veri toplama araçları; fene yönelik tutum ölçeği ile ses ve özellikleri ünitesine yönelik başarı testi ise nicel veri toplama araçları olarak kullanılmıştır. İçerik ve betimsel analizin birlikte kullanıldığı araştırmanın sonucunda, tasarım temelli fen eğitimi uygulamalarının altıncı sınıf düzeyi öğrencilerinin fen başarılarında ve tutum puanlarında artışa neden olduğu ve katılımcı öğrencilerin Fen Bilimleri dersine yönelik görüşlerinde olumlu yönde değişim gerçekleştiği tespit edilmiştir.
Astronomi Öğretmen Kampı Kazanımları: Fen Bilimleri Öğretmenlerinin Alan Bilgileri ve Sınıf İçi Uygulamaları Üzerine Bir İnceleme
Authors: BODUR Zeynep , ARABACIOĞLU Sertaç
Published: June 2023

Bu çalışmanın amacı, astronomi öğretmen kampının fen bilimleri öğretmenlerinin astronomi alan bilgileri ve sınıf içi uygulamaları üzerine etkilerinin araştırılmasıdır. Astronomi kampları, zengin içerik unsurları ve yoğun öğrenme deneyimleri ile mesleki gelişim fırsatları içerisinde öğretmenlerin öncelikli tercihleri arasındadır. “Penceremde Dünya Var 2” başlıklı kamp ve sonrasındaki izleme süreçlerine uzanan incelemeler, öğretmenlere kazandırılması hedeflenen astronomi bilgi ve kavrayışları ile ilişkili olarak, sınıf içi uygulamalar üzerine kampın potansiyel etkilerini açıklamaktadır. Nicel ve nitel veri toplama yaklaşımlarının kullanıldığı çalışma, kamp katılımcısı 35 fen bilimleri öğretmeni ile gerçekleştirilmiştir. Veri toplama sürecinde dört aşamalı bilgi testleri, yansıtıcı değerlendirme formları ve izlemeye dönük görüşmelerden yararlanılmıştır. Sonuçlar, kampın öğretmen astronomi alan bilgisini pozitif yönde anlamlı derecede etkilediğini göstermektedir. Bunun yanı sıra nitel incelemeler, kampın sınıf uygulamalarını desteklemeye dönük etkilerinin, sadece öğretmen alan bilgisi ile sınırlı bir repertuarda gerçekleşmediğini göstermiştir. Nitel veriler, astronomi kamp etkinliklerinin öğretmenlere katkılarının pedagojik alan bilgileri üzerinden sınıf ortamlarına yansıtıldığını destekleyen güçlü kanıtlar sunmaktadır. Araştırma, astronomi kamplarının başta öğretmen bilgi ve kavrayışına etkilerini, sonrasında da sınıf uygulamalarını destekleme potansiyellerini daha geniş bir şekilde tanımlayarak alan yazına katkıda bulunmaktadır.
COVID-19 Pandemi Sürecinde Okul Öncesi Velisi Olmak
Authors: OKATAN Özlem , TAGAY Özlem
Published: June 2023

Bu araştırmada okul öncesi velilerinin COVID-19 pandemi sürecinde pandemi, eğitim, teknoloji kullanımı ve aile içi etkileşim ile ilgili görüşleri incelenmiştir. Bu çalışmada nitel araştırma modeli olan olgubilim (fenomonoloji) deseni kullanılmıştır. Araştırmanın verileri 2020-2021 eğitim-öğretim yılı güz döneminde, Türkiye’de eğitim-öğretimin tüm kademeler için tamamen çevrimiçi olduğu bir zaman diliminde toplanmıştır. Araştırmaya çocuğu, Burdur il merkezi ve ilçelerindeki devlet okullarına devam eden 52 okul öncesi velisi katılmıştır. Araştırmanın verileri pandemi kaynaklı sosyal izolasyon nedeniyle, elektronik ortamda toplanmıştır. Veri toplama aracı olarak araştırmacılar tarafından oluşturulan yarı yapılandırılmış görüşme formu kullanılmıştır. Veriler içerik analizi yöntemiyle analiz edilmiştir. Araştırmadan elde edilen bulgulara göre; velilerin ve çocukların pandemi ile ilgili kaygılı olduğu, velilerin en çok eğitim, sağlık ve teknoloji kullanımına dair kaygılı olduğu, hem velilerin hem çocukların pandemi sürecinde teknoloji kullanımının arttığı, velilerin pandemi ile ilgili gelişmeleri daha çok televizyon ve telefon/tabletten günde en az bir kez takip ettiği, okul öncesi çocuklarının büyük çoğunluğunun Milli Eğitim Bakanlığı’nın sağlandığı uzaktan eğitim faaliyetlerine düzenli olarak katıldığı, velilerin uzaktan eğitim faaliyetlerini gerekli gördüğü, velilerin eğitimi desteklemek amacıyla kaynak kitaplara ve web tabanlı eğitim ortamlarına başvurduğu, çocukların genel olarak okula dönmeye istekli olduğu, pandemi döneminin aile-çocuk ilişkisine olumlu ve olumsuz bir çok etkisinin olduğu sonucuna ulaşılmıştır.
Türkiye’de Mühendislik Tasarım Temelli Öğretim İle İlgili Fen Eğitimi Alanında Yapılan Çalışmaların Tematik Analizi
Authors: ÖZÜNLÜ Özgür , ÇEPNİ Salih
Published: June 2023

Türkiye’de mühendislik tasarım temelli fen öğretimi (MTTFÖ) ile ilgili, 2013 ile 2022 yıllarını kapsayan 10 yılda yapılan çalışmaları analiz etmeyi amaçlayan bu araştırmada tematik analiz yöntemi kullanılmış olup, Ulakbim, DergiPark ve Google Akademi’de yer alan dergilerdeki makaleler ve Yüksek Öğretim Kurulu (YÖK) Ulusal Tez Merkezi’nde yer alan lisansüstü tezlerini kapsayan çalışmalar incelenmiştir. Yapılan taramalar sonucunda mühendislik tasarım temelli fen öğretimi ile ilgili yapılan 21 makale ve 19 tez olarak toplamda 40 çalışma araştırmaya dahil edilmiştir. Araştırma kapsamında incelenen çalışmalar matris kullanılarak analiz edilmiş, veriler içerik analizi ve betimsel istatistik tekniklerle çözümlenmiştir. Verilerin analizleri iki alan uzmanı tarafından gerçekleştirilmiş ve Cohen’s kappa katsayısı 0.80 bulunmuştur. Çalışmaların örneklemini en çok ortaokul öğrencileri ve öğretmen adaylarının oluşturduğu görülmektedir. MTTFÖ’ye dayalı materyallerin etkilerinin irdelendiği araştırmalarda öğrencilerin mühendisliğe yönelik algı ve tutumlarının yanında bu çalışmalarda asıl vurgunun öğrencilerin becerilerinin geliştirilmesi ve akademik başarılarına olan etkisinin irdelendiği ve daha çok MTTFÖ’nin bu iki değişkeni pozitif yönde etkilediği görülmüştür. Gelecek çalışmaların araştırma konuları arasında fen öğretim programlarının kazanımları ile MTTFÖ ilişkilendirilip bu yönde öğretmen ve öğrencilere yönelik rehber materyalin hazırlanması, 21. Yüzyıl becerilerinden yaşam ve meslek becerilerini hayata yansıtacak uygulamalara yer verilmesi şeklinde geleceğe yönelik öneriler sunulmuştur.
Assessing Bulgarian SMES’ Maturity for Industry 4.0 Implementing – The Case of “Montana Hydraulics” Ltd
Authors: Peneva Gabriela , Andreev Ognyan
Published: June 2023

The publication presents the application of developed in Peneva (2021) “Model for Assessing Bulgarian SMEs’ Readiness for Industry 4.0” in a Bulgarian SME: “Montana Hydraulics” Ltd. In the model, the approach of the series of international standard ISO/IEC 33000 “Information Technology – Process Assessment” is used and adapted. For this purpose, the current state of the SME was analyzed and its maturity was assessed according to 5 Industry 4.0 priority areas selected together with the company’s management. Based on the research, measures are proposed to reach the target maturity and recommendations for investment priorities about these 5 target areas are made.
Toolkit for Assessing Entrepreneurial Competencies among Learners
Authors: Yordanov Daniel
Published: June 2023

The growth of entrepreneurship education has raised questions related to the measurement of entrepreneurial competencies, which has led to an increase in the number of studies focused on the latter. If we aim to develop such competences, it should be possible to measure them before and after the intervention and to prioritize the competences that benefit individual development and to provide academics with up-to-date information on the various factors, which influence their development. In this article, we present a toolkit for assessing entrepreneurial competencies, based on 15 competencies set out in the European Commission's Entrepreneurship Framework (EntreConp).
Strategies and Policies to Support the Development of AI Technologies in Europe
Authors: Molhova Miglena , Biolcheva Petya
Published: June 2023

The starting point for this particular research is to uncover the relationship between the establishment of the regulatory framework, the implementation of various European digitisation development programmes and other types of enabling environment (financial instruments and programmes) with the demonstrated performance of business and science in the form of registered patents in the field of AI. The scope of the study is limited to the specific legal documents in the field of artificial intelligence, the financial mechanisms that Europe applies to stimulate research in this field, as well as to the applications filed and patents granted for technologies in the field of artificial intelligence, namely: machine understanding technologies. The study’s main results show that technology companies follow their own technology policies to meet market demands and trends, and support mechanisms (in the form of policies, programmes, and financial incentives) are more the result of technological developments than the other way around.
Bulgaria's Technological Development Through the Prism of Higher Education Policies
Authors: Ivanov Ivaylo , Molhova Miglena
Published: June 2023

The current paper aims at studying the technological development and the economic growth related with it from the perspective of the development of human brains and cognitive abilities of people, thus linking it to the educational framework, strategies, and policies, which a country sets as a basis for such development. The paper focuses on the technological development of Bulgaria and relating it to the country’s educational development. The research question set in the current paper is if and how technological development of a country is influenced by its educational policies in the field of higher education. Main results of the study show that Bulgaria has implemented a number of educational changes during the past 30 years, arguing that doing so will assist the nation achieve higher levels of socioeconomic development. There are still significant educational inequalities based on location and socioeconomic background, and overall productivity increases have not yet fully translated into sustainable and equitable growth in Bulgaria.
Intelligent Animal Husbandry: Farmer Attitudes and A Roadmap for Implementation
Authors: Petropoulos Dimitrios , Fotios Koutroubis , Valchev Evgeni
Published: June 2023

In order to preserve and develop sheep breeding, it is necessary for traditions to meet with intelligent technologies. This will ensure a better quality of animal products (both dairy and meat), increase the health status of the animals, reduce their stress levels, optimize the costs of the farmers and a number of other benefits. The purpose of this article is to show the possibilities of intelligent technologies in modern sheep farming. In it, one hundred different farms in southern Greece were studied and the attitudes of their owners towards the implementation of intelligent monitoring of sheep flocks were established. Analyzes of farmers’ propensity to adopt AI technologies are performed. On this basis, a road map has been proposed, facilitating the process of introducing intelligent sheep farming. It is applicable both to the study area and to other geographical areas with sheep farming traditions.
Public Speaking bagi Tim Penggerak Pembinaan Kesejahteraan Keluarga Kelurahan Cibubur Jakarta untuk Menunjang Presentasi
Authors: Giantika Gan Gan , Utomo Ichsan Widi , Munanjar Azwar , Susilowati Susilowati
Published: June 2023

Mengingat masih banyaknya anggota penggerak Pembinaan Kesejahteraan Keluarga (PKK) PKK yang masih takut dan tidak percaya diri dalam menyampaikan informasi ataupun pesan yang terdapat di dalam materi presentasi sehingga dibutuhkan cara dan tekhnik dalam public speaking pada saat memberikan presentasi, yaitu berupa pelatihan untuk keberanian berbicara di hadapan publik. Pada kegiatannya Tim Penggerak Pembinaan Kesejahteraan Keluarga (PKK) Kelurahan Cibubur Jakarta memerlukan pengetahuan akan cara melakukan presentasi yang baik khususnya dalam tekhnik public speaking. Metode pelaksanaan yang digunakan adalah dengan pelatihan dilakukan secara langsung dan tatap muka dengan melakukan beberapa tahapan yaitu tahap persiapan yaitu survey lokasi kegiatan, tahap pelaksanaan dari Pengabdian Masyarakat dengan tema yaitu Public Speaking bagi Tim Penggerak PKK Kelurahan Cibubur Jakarta untuk menunjang presentasi. Hasil yang diperoleh dari hasil kuesioner secara signifikan merasa puas akan pelaksanaan Pengabdian Masyarakat sehingga dapat diartikan Pengabdian berhasil dengan baik dan dari hasil saran yang diajukan peserta ternyata beberapa dari peserta berharap tema Public Speaking ini dilakukan pengembangannya dan ditambah waktunya khusu untuk prektek bagi pesertanya.
Single-Stage Extracranial and Intracranial Stenting of the Internal Carotid Artery in a Patient with Open Circle of Willis and Associated Renovascular Hypertension
Authors: Agarkov Maksim V. , Safuanov Alexey A. , Evreeva Svetlana T. , Gertsog Olga B. , Safuanova Olga S. , Popov Vitaly V. , Khilchuk Anton A.
Published: June 2023

We describe a case of 72-year-old patient with recurrent transient ischemic attacks in the right internal carotid artery (ICA) territory associated with uncontrolled hypertension. Duplex ultrasonography und carotid angiography showed a 60% stenosis with signs of a vulnerable plaque in the cervical segment, as well as a 90% stenosis in the cavernous segment of the right ICA. After further examination the patient was diagnosed with an 80% renal artery stenosis. First, the patient had a single-stage stenting for extracranial and intracranial stenoses of the right ICA, then left renal artery stenting. No intraoperative and postoperative complications were observed. These results show that this surgical treatment is minimally invasive, safe, and effective in symptomatic patients and may be considered for the disease.
Predictors of In-Hospital Mortality Among Patients with COVID-19 Related Stroke
Authors: Rakhmatullin Airat R. , Kutlubaev Mansur A. , Khayrullin Amir T.
Published: June 2023

Introduction. COVID-19-related stroke is associated with a significantly higher mortality than COVID-19 or stroke alone. Mechanisms underlying the increased mortality of patients with stroke and COVID-19 should be thoroughly studied.
Objective: to analyze predictors of hospital mortality associated with COVID-19-related stroke.
Materials and methods. We retrospectively analyzed 1,386 cases of COVID-19-related stroke reported by an infectious diseases inpatient clinic in 2020. We studied clinical, laboratory, and instrumental parameters in patients with different outcomes. Logistic regression was used to identify independent predictors of mortality.
Results. 539 (38.9%) patients died during their hospital stay, with 437 (38.0%) deaths from ischemic stroke and 102 (42.7%) deaths from hemorrhagic stroke (p = 0.0001). Independent predictors of mortality associated with COVID-19-related stroke included age, neurological deficit severity measured by NIHSS, COVID-19 severity, and laboratory parameters including white blood cell count, creatinine, glucose, and D-dimer blood levels.
Discussion. The results of logistic regression analysis were able to explain only 41% of the variability in hospital deaths among patients with stroke associated with COVID-19.
Conclusion. Hospital mortality in patients with COVID-19-related stroke is associated with severity of inflammatory response, impaired coagulation, age, neurological deficit severity, and somatic comorbidities.
The Management of High-Frequency Episodic and Chronic Migraines with Calcitonin Gene-Related Peptide Monoclonal Antibody
Authors: Dobrynina Larisa A. , Afanasev Maksim A. , Belopasova Anastasia V. , Gubanova Maria V. , Baydina Ekaterina V.
Published: June 2023

Introduction. High prevalence of migraine and its impact on quality of life requires the development of original agents. In 2020, fremanezumab, a new calcitonin gene-related peptide monoclonal antibody was authorized in Russia.
Objective: to evaluate safety and effectiveness of fremanezumab in patients with high-frequency episodic migraine (HF EM) and chronic migraine (CM).
Materials and methods. We assessed 60 patients at the age of 35.5 8.96 years (85%, females) with HFEM and CM with and without aura who were either receiving preventive treatment or not. Fremanezumab was administered subcutaneously at a single dose of 675 mg. The study participants were followed-up for efficacy in 3 months. The investigators assessed change in the number of days with headache per month as well as headache intensity, its impact on the daily activities, anxiety, and depression.
Results. By the end of month 3 post dosing, the number of days with headache decreased by 50% in 76.7% of participants where 77.8% of individuals suffered from HF EM and 72.7% of individuals had CM while headache intensity decreased in all the patients equally. No response (decrease in the number of days with headache by 30%) was reported in 15% of participants including 14.8% of individuals with HF EM and 15.2% of individuals with CM. By the end of study month 3, 81% of participants demonstrated no anxiety symptoms and 79% of participants showed no depression with significant MIDAS and HIT-6 score decline in both groups. Only 3 (5%) patients noted adverse events (redness, itching at the administration site).
Conclusion. We documented higher fremanezumab safety and effectiveness in patients with EM and CM in real-world practice as compared to fremanezumab safety and efficacy in randomized clinical trials. A single dose of fremanezumab (675 mg) resulted in effective migraine prevention, decline in comorbid anxiety and depression, and improved quality of life during 3-month follow-up.
Morphological Changes in Neural Progenitors Derived from Human Induced Pluripotent Stem Cells and Transplanted into the Striatum of a Parkinson's Disease Rat Model
Authors: Voronkov Dmitry N. , Stavrovskaya Alla V. , Lebedeva Olga S. , Li Wen , Olshansky Artem S. , Gushchina Anastasia S. , Kapkaeva Marina R. , Bogomazova Alexandra N. , Lagarkova Maria A. , Illarioshkin Sergey N.
Published: June 2023

Introduction. Development of cell therapy for Parkinson's disease (PD) requires protocols based on transplantation of neurons derived from human induced pluripotent stem cells (hiPSCs) into the damaged area of the brain.
Objective: to characterize neurons transplanted into a rat brain and evaluate neural transplantation efficacy using a PD animal model.
Materials and methods. Neurons derived from hiPSCs (IPSRG4S line) were transplanted into the striatum of rats after intranigral injection of 6-hydroxydopamine (6-OHDA). Immunostaining was performed to identify expression of glial and neuronal markers in the transplanted cells within 224 weeks posttransplant.
Results. 4 weeks posttransplant we observed increased expression of mature neuron markers, decreased expression of neural progenitor markers, and primary pro-inflammatory response of glial cells in the graft. Differentiation and maturation of neuronal cells in the graft lasted over 3 months. At 3 and 6 months we detected 2 graft zones: one mainly contained the transplanted neurons and the other human astrocytes. We detected human neurites in the corpus callosum and surrounding striatal tissue and large human tyrosine hydroxylase-expressing neurons in the graft.
Conclusion. With graft's morphological characteristics identified at different periods we can better understand pathophysiology and temporal patterns of new dopaminergic neurons integration and striatal reinnervation in a rat PD model in the long-term postoperative period.
Deep Multiple Instance Learning Approach for Classification in Clinical Decision Support Systems
Authors:   Department of Computer Science and Engineering Nitte Meenakshi Institute of Technology Bengaluru India, .. Vani. ,   Department of Artificial Intelligence and Machine Learning Nitte Meenakshi Institute of Technology Bengaluru India, Pareek Piyush Kumar
Published: June 2023

To get around the drawbacks of conventional classification algorithms that required manual feature extraction and the high computational cost of neural networks, this paper introduces a deep convolutional neural network with multiple instance learning approaches, namely dynamic max pooling and sparse representation. For the categorization of tuberculosis lung illness, this model combines deep convolutional neural networks and multiple instance learning. The design was composed of four phases: pre-processing, instance production, feature extraction, and classification. To perform feature extraction, a model based on a customized version of the VGG16 architecture was trained from scratch. Multiple instance learning techniques such as Diverse Density (DD) and the Maximum pattern bag formulation of the Support Vector Machine were used to evaluate how well the proposed classification algorithm performed in comparison (SVM).The numerical findings demonstrated that the new method offered a higher level of accuracy than the methods that had been used in the past. When evaluating the efficacy of the current method, accuracy, specificity, sensitivity, and error rate were all taken into consideration. The accuracy of the max-pooling based framework and the sparse representation framework was found to be greater than that of the other multiple instance strategies, coming in at 91.51% and 89.84%, respectively, when compared to that of the other methods. The improved accuracy of the present system that makes use of deep neural networks is mostly attributable to the contributions made by features such as transfer learning and automatic feature extraction.
Multimedia Imaging System of Data Collection and Antenna Alignment for Unmanned Aerial Vehicles Based Internet of Things
Authors:   Technical engineering collage, Northren technical university (NTU), Mosul, Iraq, qasim Maysaloon abed ,   Blended Learning Department, College of Administration and Economics, Tikrit University, Tikrit, Iraq,   Labs Department, High school of Al-Motafukeen, Salahaldin Education, Tikrit, Iraq,   Information and Communication Engineering, Al-Nahrain University, Baghdad, Iraq,   Computer Techniques Engineering Department, Al-Mustaqbal University, Babil, Iraq, Ali Qusay Abboodi , Sahab Noor Mezher , Jaleel Refed Adnan , Zahra Musaddak Maher Abdul
Published: June 2023

Because network of sensors gives a more accurate representation of remotely sensed environments, a network of wirelessly connected sensors is essential. Data packets must be routed to the base station hop by hop, which causes conventional network data collecting to use a lot of power. Unmanned aerial vehicles (UAV) were employed for hovering over the detected environment and gather data to solve this issue. The paper also aims to provide an automatic alignment for UAV antennas for tracking by utilising computer vision technologies. A directional antenna with high gain is used by a ground station that can operate by a pan-tilt to point towards the low-gain omnidirectional antenna carried by the UAV. To center the UAV's antenna's image in the frame, the antenna is equipped with a camera, and a computer detects the video and controls the pan-tilt. The antennas are aligned if there are no more than a few pixels between the UAV image center and the image center. The proposed imaging system exhibits fast data collection, thus attaining a high packet delivery rate and the minimum use of energy. With the suggested antenna auto-alignment approach, the antennas can be accurately aligned with an angle error of under one. UAVs must take the smoothest and shortest pathways possible to accommodate their motion and time constraints. As a result, the Traveling Sales Problem (TSP) is utilized to determine the shortest route, and Bezier curves are then employed to turn paths into a flyable path.
An Extended Neutrosophic Stepwise Weight Assessment Ratio Analysis Technique Based on GIS for Analysing Flash Floods
Authors:   Department of Information Systems, Faculty of Computers and Informatics, Zagazig University, Sharqiyah, Egypt, AbdelAziz Nabil M. ,   Department of Information Systems, Faculty of Computers and Informatics, Zagazig University, Sharqiyah, Egypt,   Department of Information Systems, Faculty of Computers and Informatics, Zagazig University, Sharqiyah, Egypt, Mohammed Hassan H. , Eldrandaly Khalid A.
Published: June 2023

Flash floods are a sudden natural hazard caused by successive heavy rains in a short period of time. The world suffers from heavy and frequent rains due to climate change. So, the risk assessment of flash floods is considered increasingly important and urgent. Egypt is considered one of the countries exposed to sudden floods resulting from heavy rains, especially in Upper Egypt. Multi-criteria techniques are widely used to study and analyze the causes and effects of natural hazards. In contrast to the traditional multi-criteria techniques used in the process of estimating flood problems, we applied neutrosophic logic in this study that has a great ability for simulating and reflecting uncertain human’s thoughts in real world problems. Our study area sits in Southeast Sohag, and it is one of the most flash floods prone regions of Egypt's Eastern Desert. This area of Sohag has suffered from frequent flash floods, with some flood events resulting in human casualties in the last decades. This study focuses on using a neutrosophic stepwise weight assessment ration analysis (N-SWARA) technique with remotely sensed data and geographical information system (GIS) for producing a flash floods hazard map. The N-SWARA technique is applied to determine the weights of various factors that related to flash flooding, including elevation, slope, topographic wetness index, distance from the stream, flow accumulation, aspect, and flow direction. The obtained weight of selected criteria used then to produce the flood hazard map (FHM) using a raster calculator tool in geographic information system. The weight of each factor calculated by using the N-SWARA multi criteria analysis method and obtained the following results: 0.39 for slope, 0.21 for elevation, 0.12 for distance, 0.08 for flow direction, 0.05 for flow accumulation, 0.09 for TWI and 0.03 for aspect.
Neutrosophic Multinominal Logistic Regression Technique for Optimizing Adaptive Reuse of Historical Castles
Authors:   Faculty of Architectural Engineering, University of Aleppo, Aleppo, Syria, Omar Rama Hussen ,   Department of Mathematical Statistics, University of Aleppo, Aleppo, Syria,   Department of Mathematical Statistics, University of Aleppo, Aleppo, Syria, .. Mohamed Najeb , Zeina Mohamed Bisher
Published: June 2023

Defining and utilizing Neutrosophic Multinomial Logistic Regression (NMLR) is significant in architecture because it introduces a novel approach to prioritizing the optimal alternative for adaptively reusing a historic building. This is particularly crucial in post-conflict recovery. NMLR presents an intelligent classification system and decision-making tool that optimizes the evaluation process for adaptive reuse projects, even under conditions of uncertainty. The integration of Neutrosophic sets and digital technologies provides decision-makers with a more accurate and reliable tool to make rational decisions regarding functional spaces reuse. The effectiveness of this approach is demonstrated through a case study of the Castle of Aleppo. The study determined that the most suitable alternative for the castle is a multi-purpose facility that caters to tourism. This approach can be adapted to various restoration projects, and the assessment of proposed alternatives can be customized according to the weight of the criteria by creating desktop application which contributes to the sustainability and improvement of post-disaster reconstruction efforts.
Terrorism & The Overview on Impacts Towards Government Policies in Malaysia, The United States and The United Kingdom
Authors: Othman Noraini , Saiful Bahri Mohd Sharazad , Yahaya Hazliana , Jen Augustine  Leonard
Published: June 2023

The terrorist acts that occur around the world, with a significant incident of September 11, have brought about changes in government policies not only in Western countries but also in Malaysia. In fact, the introduction of the Security Offences (Special Measures) Act (SOSMA) 2012 in Malaysia is one of the significant legislations in combating terrorism. Anti-Terrorism legislation is, without a doubt, a sine qua non for countries in pursuit of their states’ stability and security. Therefore, this article evaluates the impacts of terrorism on government policies in Malaysia, the United States and the United Kingdom and emphasis will be placed on whether the policies, i.e., the domestic legislation carried out, manage to play a significant role in combating terrorism.
Fragments Re-Connected
Authors: Tahkokallio Jaakko
Published: June 2023

The large fragment collections of the National Archives of Sweden and National Library of Finland share the same early modern history of recycling. Because of this, leaves from one medieval manuscript are often divided between these two collections. This article establishes a series of new inter-archival connections between fragments stemming from the same book. It focuses on missal fragments dated to the twelfth or early thirteenth century. In addition, it presents preliminary observations on how the recycling history helps us to contextualise the fragments preserved in Finland as historical evidence.
Lectio praecursoria: The Good Noblemen Who Conquered the Kingdom: Islam, Historiography, and Aristocratic Legitimation in Late-Medieval Portugal
Authors: Queimada e Silva Tiago
Published: June 2023

This text consists of the 'lectio praecursoria' given at the defense of my doctoral dissertation "The Good Noblemen Who Conquered the Kingdom:  Islam, Historiography, and Aristocratic Legitimation in Late-Medieval Portugal". This dissertation deals with aristocratic historiography and political legitimation in late-medieval Portugal (late thirteenth and fourteenth centuries). It offers a perspective into the historical imaginary of the late-medieval Portuguese aristocracy; an imaginary that underlay the argumentation of members of this social class in defence of their traditional rights and jurisdictions against politicalcentralisation. It examines how the medieval Portuguese aristocracy utilized memories of past interactions with Islam to justify its privileged social status and defend its traditional prerogatives at a time when this social group opposed the royalist policy of political centralization. This research is included into wider debates on the role of culture — in this case, historical culture — as a resource to justify, reinforce, reproduce, and transform an existing social order.
The Validity and the Reliability Study of A Cyber Victimization/Bullying Scale For University Students
Authors: BAYAR Alper , KURT Bilge Sena , MUTLU Mahir , ÖVEN Çağrı , BAYAR Yusuf
Published: June 2023

The main purpose of this study was to develop a cyber victimization/bullying scale for university students and to test the validity and reliability of the scale. In the first step of this study, the validity and reliability of the cyber victimization scale were tested. The first study sample consisted of 486 university students, 320 (65.8%) female, and 166 (34.2%) male. As a result of the exploratory factor analysis, a 6-factor structure was obtained. The identified subscales for the victimization form were "substitution, verbal teasing, social exclusion, disclosure, cyber victimization with sexual content, anonymous cyber victimization," The total Cronbach's alpha for the victimization form was .81. In the second step, a parallel bully form was created with the same items. The second study sample consisted of 208 university students, 130 (62.5%) female, and 78 (37.5%) male. As a result of the exploratory factor analysis, a similar 6-factor structure was obtained. The identified subscales for the bullying form were "substitution, verbal teasing, social excluding, disclosure, cyberbullying with sexual content, and anonymous cyberbullying." The total Cronbach's alpha for the bullying form was .93. The results of exploratory factor analysis and reliability analysis indicated that the cyber victimization/bullying scale was a qualified scale that could be preferred in scientific studies conducted with university students.
Carbon-Tunable p-type ZnO Nanoparticles for Enhanced Photocatalytic Removal of Eriochrome Black T
Authors: YUSHAU Auwal , GAYA Umar
Published: June 2023

Zinc oxide-mediated photocatalysis is a promising alternative to TiO2 photocatalysis, especially for the purpose of removal of recalcitrant organic dye pollutants. Highly crystalline, nanoscopic carbon-doped ZnO was successfully synthesized via combined precipitation and mechanochemical approach and characterized using x-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive x-ray (EDX) and Fourier transform infrared (FTIR) spectrometry. The obtained photocatalysts depict plate-like morphology and hexagonal wurtzite structure. The XRD, SEM, and FTIR analyses were in good agreement with EDX results. The 5wt % C-doped ZnO showed remarkable visible light-photocatalytic activity based on the degradation of Eriochrome Black T (EBT), and exhibits the best point of zero charge (pHpzc) for a favorable adsorption equilibrium. This degradation process was optimized at 97 % using response surface methodology (RSM) using a 0.1 g C-ZnO, 5.00 mg/L EBT and pH 11. The associated kinetic data fit the pseudo-first-order kinetic model. The resulting C-ZnO was a p-type with a good pH at zero-point charge that permits the substantial removal of EBT by C-doped under visible light irradiation over a wide range of initial pH.
Quantum Chemical Study of Some Basic Organic Compounds as the Corrosion Inhibitors
Authors: AHMED Lana , BULUT Niyazi , KAYGILI Omer , OMER Rebaz
Published: June 2023

The corrosion inhibitor activities of 10 molecules (Benzene (C1), Phenol (C2), Toluene (C3), Benzoic acid (C4), Acetophenone (C5), Chlorobenzene (C6), Bromobenzene (C7), Benzaldehyde (C8), Naphthalene (C9), and Anthracene (C10) were investigated using quantum mechanical methods. The energy of the highest occupied molecular orbital (EHOMO), the energy of the lowest occupied molecular orbital (ELUMO), the energy bandgap (E = ELUMO - EHOMO), and the dipole moment (μ) were all estimated in this study. The parameters mentioned can provide information about the corrosion efficiency of organic compounds. In addition, the density functional theory (DFT) was used to determine the geometry of the molecules as well as the electronic properties of the compounds. Physical parameters such as chemical hardness (ɳ), softness (σ), and electronegativity (χ) were determined using B3LYP/6-31G (d, p). As well as the quantum chemistry properties like the fraction of electrons transported (ΔN) between the iron surface and the titled compounds have been calculated. This research also aimed to find which variables have a significant linear relationship with inhibitory performance. According to the results, the behavior of organic-based corrosion inhibitors is related to the effectiveness of good corrosion inhibitors and the quantum chemical parameters measured during this process. As a result, corrosion inhibitor behavior can be predicted without the need for an experiment.
The Relationship between Kidney Stones and Dietary Habits Using XRF Technique
Authors: AHMED Lana , CHAQMAQCHEE Assist.prof.dr. Faten Adel , OMER Rebaz
Published: June 2023

Abstract

Kidney stones are considered a severe disease that causes considerable pain and can lead to kidney failure. Dietary habits may be the reason behind the development of stones in the kidneys. Twelve kidney stone samples were collected and analyzed using an X-ray fluorescent technique along with commonly consumed foodstuffs in the Koya region of northern Iraq. It was observed that all of the stones were based on calcium element. The findings reveal that Ca, Zr, S, and Cl can be the core elements of forming kidney stones in such an area. The core elements were found to include many dietary foods commonly consumed by many in the Koya region. More studies are required, however, to see whether dietary intake may be the main cause of kidney stone formation.
Density Function Theory Study of the Physicochemical Characteristics of 2-nitrophenol
Authors: HAMAD Othman , OBAID KAREEM Rebaz , KAYGILI Omer
Published: June 2023

2-Nitrophenol (2-NP) is utilized in the production of bio-refractory organic compounds, and petrochemicals, and in the synthesis of many drugs and weed killers. The chemical structure of 2-NP is C6H5NO3. The structure of 2-NP is important as the nitro group (NO2. In this present investigation, the Gaussian 5.0 program was used to compute the difference in energy level that exists between the HOMO and LUMO states of the BGs.This information was then used to optimize the shape of the 2-NP structures using DFT methods. The 3-21G/B3LYP base set has a minimum value for the BG energy of 3.48 eV. This is the minimum value that can be achieved. The DOS for 2-NP was measured to have its maximum possible value of 2.23 ev/atom. According to the results of the IR, and Raman spectrum, the C-H stretching vibration peak for 2-NP was found to be between 3208.96 cm-1 and 3243.76 cm-1. The maximum excitation energy was analyzed at a wavelength of 382.1 nm, and the oscillator strength was determined at 0.0537 UV Spectroscopy. In the potential energy map (PE), the colors are changed from blue to red in the range of -4.442e-2 to 4.442e-2.
Solvents Effect on 4-Phenyl-5-(2-Thienyl)-2,4-Dihydro-3H-1,2,4-Triazol-3-Thion Molecule: Experimental And Theoretical Study
Authors: TEMÜZ M.mürşit , KOPARIR Pelin , YILDIRIM Mehmet
Published: June 2023

In this study 4-phenyl-5-(2-thienyl)-2, 4-dihydro-3H-1,2,4-triazol-3-thion was synthesized using experimental method and later characterized using spectroscopic methods. The titled molecule is then designed, optimized and charaterized with theoretical first principle method. The result compared and the titled molecule is solvated with polar and non-polar solvent to see the effect of their interaction and changes that occurs in the spectroscopic results.
Structural water self-organization in river flow
Authors:   Water Problems Institute, Russian Academy of Sciences, Moscow, Russia, Rozental O. M , Fedotov V. Kh. ,   Chuvash State University, Cheboksary, Russia
Published: June 2023

Application of neural-network methods revealed relationships between hydrological and hydrochemical characteristics of water flow, suggesting structural self-organization of substances dissolved in water in the form of micro layering. In particular, the coefficient of correlation between the concentrations of such substances in some cases reaches its nearly maximal value (0.99), combining with the high weights of neural network edges. This can be supposed to be due to the mechanical and chemical interactions in river flow with the participation of Van der Waals forces, hydration, and sorption. Other factors, not taken into account, can also have their effect, in particular those responsible for the fluctuations of the parameters of order, determining the singular contributions to the dynamic characteristics of the non-linear system under consideration. Such can be the cyclic oscillations of the characteristics under control with an amplitude decreasing with a decrease in the intensity of the pollution/selfpurification processes in water medium and increasing with an increase in this intensity. The obtained information, in addition to its direct purpose as a means to study the nature and properties of fresh water, is a necessary condition for the effective control of water resource quality and water management activity.