bluuebunny/crossref_metadata_2025 huggingface dataset:
A Clinical Approach to Semiautomated Three-Dimensional Fetal Brain Biometry—Comparing the Strengths and Weaknesses of Two Diagnostic Tools: 5DCNS+TM and SonoCNSTM
Authors: Gembicki Michael , Welp Amrei , Scharf Jann Lennard , Dracopoulos Christoph , Weichert Jan
Published: August 2023

(1) Objective: We aimed to evaluate the accuracy and efficacy of AI-assisted biometric measurements of the fetal central nervous system (CNS) by comparing two semiautomatic postprocessing tools. We further aimed to discuss the additional value of semiautomatically generated sagittal and coronal planes of the CNS. (2) Methods: Three-dimensional (3D) volumes were analyzed with two semiautomatic software tools, 5DCNS+™ and SonoCNS™. The application of 5DCNS+™ results in nine planes (axial, coronal and sagittal) displayed in a single template; SonoCNS™ depicts three axial cutting sections. The tools were compared regarding automatic biometric measurement accuracy. (3) Results: A total of 129 fetuses were included for final analysis. Our data indicate that, in terms of the biometric quantification of head circumference (HC), biparietal diameter (BPD), transcerebellar diameter (TCD) and cisterna magna (CM), the accuracy of SonoCNS™ was higher with respect to the manual measurement of an experienced examiner compared to 5DCNS+™, whereas it was the other way around regarding the diameter of the posterior horn of the lateral ventricle (Vp). The inclusion of four orthogonal coronal views in 5DCNS+™ gives valuable information regarding spatial arrangements, particularly of midline structures. (4) Conclusions: Both tools were able to ease assessment of the intracranial anatomy, highlighting the additional value of automated algorithms in clinical use. SonoCNS™ showed a superior accuracy of plane reconstruction and biometry, but volume reconstruction using 5DCNS+™ provided more detailed information, which is needed for an entire neurosonogram as suggested by international guidelines.
Advances in Endoscopic Management of Endobronchial Carcinoid
Authors: Messina Gaetana , Pica Davide , Vicario Giuseppe , Bove Mary , Natale Giovanni , Di Filippo Vincenzo , Capasso Francesca , Mirra Rosa , Panini D’Alba Francesco , Conzo Giovanni , Posta Tecla , Giorgiano Noemi , Vicidomini Giovanni , Capaccio Damiano , Peritore Valentina , Teodonio Leonardo , Andreetti Claudio , Rendina Erino , Fiorelli Alfonso
Published: August 2023

Introduction: Bronchial carcinoid (BC) tumors represent between 1% and 5% of all lung cancers and about 20–30% of carcinoid tumors; they are classified into two groups: typical and atypical bronchial carcinoids. The aim of the present study was to review the results of endoscopic treatments as an alternative to surgical treatment in selected patients. Materials and methods: The present study was a retrospective and multicentric study, in which all data were reviewed for patients with BC in the central airways, referred to the Thoracic Surgery Units of Luigi Vanvitelli University of Naples and Sant’Andrea Hospital in Rome between October 2012 and December 2022 Overall, 35 patients, 13 of whom were female, were included in the study (median age, 53 years; range, 29–75 years). All patients underwent rigid bronchoscopy combined with flexible bronchoscopy. Tumor clearance was mostly performed by use of Argon Plasma Coagulation or Thulep Laser, mechanical debridement and excision with the use of forceps and aspirator through the working channel of the 8.5 mm-sized rigid bronchoscope. There were no complications during the treatment. Results: Endobronchial treatment provided complete tumor eradication in all patients; two patients had controlled bleeding complications; however, bleeding was well controlled without patient desaturation, and only one patient died of renal failure during the follow-up period. We found two recurrences in the left and right main bronchus, in patients with atypical carcinoma during fiberoptic bronchoscopy follow-up. Only one patient died of renal failure. At the first analysis, there were no significant differences between the patients receiving endobronchial treatment and patients receiving surgical treatment in the present study (p-value > 0.05—it means statistically insignificant). Conclusions: Endobronchial treatment is a valid and effective alternative for patients with BC unsuitable for surgery.
Mechanical and Functional Improvement of β-TCP Scaffolds for Use in Bone Tissue Engineering
Authors: Umrath Felix , Schmitt Lukas-Frank , Kliesch Sophie-Maria , Schille Christine , Geis-Gerstorfer Jürgen , Gurewitsch Elina , Bahrini Kathleen , Peters Fabian , Reinert Siegmar , Alexander Dorothea
Published: August 2023

Autologous bone transplantation is still considered as the gold standard therapeutic option for bone defect repair. The alternative tissue engineering approaches have to combine good hardiness of biomaterials whilst allowing good stem cell functionality. To become more useful for load-bearing applications, mechanical properties of calcium phosphate materials have to be improved. In the present study, we aimed to reduce the brittleness of β-tricalcium phosphate (β-TCP). For this purpose, we used three polymers (PDL-02, -02a, -04) for coatings and compared resulting mechanical and degradation properties as well as their impact on seeded periosteal stem cells. Mechanical properties of coated and uncoated β-TCP scaffolds were analyzed. In addition, degradation kinetics analyses of the polymers employed and of the polymer-coated scaffolds were performed. For bioactivity assessment, the scaffolds were seeded with jaw periosteal cells (JPCs) and cultured under untreated and osteogenic conditions. JPC adhesion/proliferation, gene and protein expression by immunofluorescent staining of embedded scaffolds were analyzed. Raman spectroscopy measurements gave an insight into material properties and cell mineralization. PDL-coated β-TCP scaffolds showed a significantly higher flexural strength in comparison to that of uncoated scaffolds. Degradation kinetics showed considerable differences in pH and electrical conductivity of the three different polymer types, while the core material β-TCP was able to stabilize pH and conductivity. Material differences seemed to have an impact on JPC proliferation and differentiation potential, as reflected by the expression of osteogenic marker genes. A homogenous cell colonialization of coated and uncoated scaffolds was detected. Most interesting from a bone engineer’s point of view, the PDL-04 coating enabled detection of cell matrix mineralization by Raman spectroscopy. This was not feasible with uncoated scaffolds, due to intercalating effects of the β-TCP material and the JPC-formed calcium phosphate. In conclusion, the use of PDL-04 coating improved the mechanical properties of the β-TCP scaffold and promoted cell adhesion and osteogenic differentiation, whilst allowing detection of cell mineralization within the ceramic core material.
Thangka Image Captioning Based on Semantic Concept Prompt and Multimodal Feature Optimization
Authors: Hu Wenjin , Qiao Lang , Kang Wendong , Shi Xinyue
Published: August 2023

Thangka images exhibit a high level of diversity and richness, and the existing deep learning-based image captioning methods generate poor accuracy and richness of Chinese captions for Thangka images. To address this issue, this paper proposes a Semantic Concept Prompt and Multimodal Feature Optimization network (SCAMF-Net). The Semantic Concept Prompt (SCP) module is introduced in the text encoding stage to obtain more semantic information about the Thangka by introducing contextual prompts, thus enhancing the richness of the description content. The Multimodal Feature Optimization (MFO) module is proposed to optimize the correlation between Thangka images and text. This module enhances the correlation between the image features and text features of the Thangka through the Captioner and Filter to more accurately describe the visual concept features of the Thangka. The experimental results demonstrate that our proposed method outperforms baseline models on the Thangka dataset in terms of BLEU-4, METEOR, ROUGE, CIDEr, and SPICE by 8.7%, 7.9%, 8.2%, 76.6%, and 5.7%, respectively. Furthermore, this method also exhibits superior performance compared to the state-of-the-art methods on the public MSCOCO dataset.
Aggregate News Sentiment and Stock Market Returns in India
Authors: Chari Sushant , Desai Purva Hegde , Borde Nilesh , George Babu
Published: August 2023

This paper contributes to the advancement of noise trader theory by examining the connection between aggregate news sentiment and stock market returns during days of significant stock market movement. In contrast to previous studies that solely focused on company-specific news sentiment, this research explores the impact of aggregate news sentiment. To draw conclusions, GARCH modeling, regression analysis, and dictionary-based sentiment analysis are employed. The findings, based on data from India, reveal that aggregate news sentiment has a short-lived influence, with notable effects stemming from the business and politics categories.
The Impacts of a Commercial Bubble Curtain on Zoo-Housed African Penguin (Spheniscus demersus) Swimming Behavior
Authors: O’Brien Shannon L. , Cronin Katherine A.
Published: August 2023

Swimming is an important behavior for all penguin species. However, zoo-housed penguins typically do not swim as often as their wild counterparts, which may have consequences for their health and welfare. In an effort to increase the swimming time of the African penguin (Spheniscus demersus) population at Lincoln Park Zoo in Chicago, IL, USA (21 adults: 13 males, 8 females), we introduced a commercially available bubble curtain to the outdoor pool within the penguins’ habitat. The bubble curtain pushes pressurized air out through a hose fitted with small holes to create a stream of bubbles that generate water movement, which could entice penguins to swim. Over the course of 2 months, the penguins were exposed to a series of alternating conditions characterized by the bubble curtain being off or on for 2-week periods. A total of 228 swimming bouts were observed during this study. The bubble curtain did not increase the amount of time the penguins spent swimming, nor the maximum number of penguins in the pool during swim bouts. Rather, the penguins spent more time swimming when the bubble curtain was turned off, and the number of penguins in the pool during swim bouts was consistent across experimental phases. Additionally, we found that penguins swam the most when air temperatures were between 31 and 40 °F (approximately −1 to −4 °C). Unexpectedly, at least three individual penguins swam overnight between the hours of midnight and 6:00, highlighting the value of monitoring animals during entire 24 h periods. Collectively, this study provides detailed information about the swimming behavior of a zoo-housed African penguin population, and indicates that a bubble curtain was ineffective at stimulating swimming.
Improving Dryland Urban Land Cover Classification Accuracy Using a Classical Convolution Neural Network
Authors: Luan Wenfei , Li Ge , Zhong Bo , Geng Jianwei , Li Xin , Li Hui , He Shi
Published: August 2023

Reliable information of land cover dynamics in dryland cities is crucial for understanding the anthropogenic impacts on fragile environments. However, reduced classification accuracy of dryland cities often occurs in global land cover data. Although many advanced classification techniques (i.e., convolutional neural networks (CNN)) have been intensively applied to classify urban land cover because of their excellent performance, specific classification models focusing on typical dryland cities are still scarce. This is mainly attributed to the similar features between urban and non-urban areas, as well as the insufficient training samples in this specific region. To fill this gap, this study trained a CNN model to improve the urban land classification accuracy for seven dryland cities based on rigorous training sample selection. The assessment showed that our proposed model performed with higher overall accuracy (92.63%) than several emerging land cover products, including Esri 2020 Land Cover (75.55%), GlobeLand30 (73.24%), GLC_FCS30-2020 (69.68%), ESA WorldCover2020 (64.38%), and FROM-GLC 2017v1 (61.13%). In addition, the classification accuracy of the dominant land types in the CNN-classified data exceeded the selected products. This encouraging finding demonstrates that our proposed architecture is a promising solution for improving dryland urban land classification accuracy and compensating the deficiency of large-scale land cover mapping.
Simultaneous Fault Diagnostics for Three-Shaft Industrial Gas Turbine
Authors: Salilew Waleligne Molla , Gilani Syed Ihtsham , Lemma Tamiru Alemu , Fentaye Amare Desalegn , Kyprianidis Konstantinos G.
Published: August 2023

The study focused on the development of -gas turbine full- and part-load operation diagnostics. The gas turbine performance model was developed using commercial software and validated using the engine manufacturer data. Upon the validation, fouling, erosion, and variable inlet guide vane drift were simulated to generate faulty data for the diagnostics development. Because the data from the model was noise-free, sensor noise was added to each of the diagnostic set parameters to reflect the actual scenario of the field operation. The data was normalized. In total, 13 single, and 61 double, classes, including 1 clean class, were prepared and used as input. The number of observations for single faults diagnostics were 1092, which was 84 for each class, and 20,496 for double faults diagnostics, which was 336 for each class. Twenty-eight machine learning techniques were investigated to select the one which outperformed the others, and further investigations were conducted with it. The diagnostics results show that the neural network group exhibited better diagnostic accuracy at both full- and part-load operations. The test results and its comparison with literature results demonstrated that the proposed method has a satisfactory and reliable accuracy in diagnosing the considered fault scenarios. The results are discussed, following the plots.
Augmenting Mobile App with NAO Robot for Autism Education
Authors: Mutawa A. M. , Al Mudhahkah Hanan Mansour , Al-Huwais Aisha , Al-Khaldi Norah , Al-Otaibi Rayuof , Al-Ansari Amna
Published: August 2023

This paper aims to investigate the possibility of combining humanoid robots, particularly the NAO robot, with a mobile application to enhance the educational experiences of children with autism spectrum disorder (ASD). The NAO robot, interfaced with a mobile app, serves as a socially assistive robotic (SAR) tool in the classroom. The study involved two groups of children aged three to six years old, exhibiting mild to moderate ASD symptoms. While the experimental group interacted with the NAO robot, the control group followed the standard curriculum. Initial findings showed that students in the experimental group exhibited higher levels of engagement and eye contact. However, certain limitations were identified, including the NAO robot’s limited capacity for concurrent interactions, language difficulties, battery life, and internet access. Despite these limitations, the study highlights the potential of robots and AI in addressing the particular educational requirements of children with ASD. Future research should focus on overcoming these obstacles to maximize the advantages of this technology in ASD education.
Recent Advances in Electrospun Fibers for Biological Applications
Authors: Fromager Bénédicte , Marhuenda Emilie , Louis Benjamin , Bakalara Norbert , Cambedouzou Julien , Cornu David
Published: August 2023

Electrospinning is a simple and versatile method to generate nanofibers. Remarkable progress has been made in the development of the electrospinning process. The production of nanofibers is affected by many parameters, which influence the final material properties. Electrospun fibers have a wide range of applications, such as energy storage devices and biomedical scaffolds. Among polymers chosen for biological scaffolds, such as PLA or collagen, polyacrylonitrile (PAN) has received increasing interest in recent years due to its excellent characteristics, such as spinnability, biocompatibility, and commercial viability, opening the way to new applications in the biotechnological field. This paper provides an overview of the electrospinning process of a large range of polymers of interest for biomedical applications, including PLA and PEO. It covers the main parameters and operation modes that affect nanofiber fabrication. Their biological applications are reviewed. A focus is placed on PAN fiber formation, functionalization, and application as scaffolds to allow cell growth. Overall, nanofiber scaffolds appear to be powerful tools in medical applications that need controlled cell culture.
A Lightweight YOLOv5-Based Model with Feature Fusion and Dilation Convolution for Image Segmentation
Authors: Chen Linwei , Yang Jingjing
Published: August 2023

Image segmentation has played an essential role in computer vision. The target detection model represented by YOLOv5 is widely used in image segmentation. However, YOLOv5 has performance bottlenecks such as object scale variation, object occlusion, computational volume, and speed when processing complex images. To solve these problems, an enhanced algorithm based on YOLOv5 is proposed. MobileViT is used as the backbone network of the YOLOv5 algorithm, and feature fusion and dilated convolution are added to the model. This method is validated on the COCO and PASCAL-VOC datasets. Experimental results show that it significantly reduces the processing time and achieves high segmentation quality with an accuracy of 95.32% on COCO and 96.02% on PASCAL-VOC. The improved model is 116 M, 52 M, and 76 M, smaller than U-Net, SegNet, and Mask R-CNN, respectively. This paper provides a new idea and method with which to solve the problems in the field of image segmentation, and the method has strong practicality and generalization value.
Outer Synchronization of Two Muti-Layer Dynamical Complex Networks with Intermittent Pinning Control
Authors: Liang Yi , Deng Yunyun , Zhang Chuan
Published: August 2023

This paper regards the outer synchronization of multi-layer dynamical networks with additive couplings via aperiodically intermittent pinning control, in which different layers of each multi-layer network have different topological structures. First, a state-feedback intermittent pinning controller is designed in the drive and response configuration, and sufficient conditions to achieve the outer synchronization are derived based on the Lyapunov stability theory and matrix inequalities. Second, outer synchronization problem of multi-layer networks is discussed by setting an adaptive intermittent pinning controller; an appropriate Lyapunov function is selected to prove the criteria of synchronization between the drive multi-layer network and the response multi-layer network. Finally, three simulation examples are given to show the effectiveness of our control schemes.
Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease?
Authors: Silva Joana , Alves Celso , Soledade Francisca , Martins Alice , Pinteus Susete , Gaspar Helena , Alfonso Amparo , Pedrosa Rui
Published: August 2023

The increase in the life expectancy average has led to a growing elderly population, thus leading to a prevalence of neurodegenerative disorders, such as Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder and is characterized by a progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). The marine environment has proven to be a source of unique and diverse chemical structures with great therapeutic potential to be used in the treatment of several pathologies, including neurodegenerative impairments. This review is focused on compounds isolated from marine organisms with neuroprotective activities on in vitro and in vivo models based on their chemical structures, taxonomy, neuroprotective effects, and their possible mechanism of action in PD. About 60 compounds isolated from marine bacteria, fungi, mollusk, sea cucumber, seaweed, soft coral, sponge, and starfish with neuroprotective potential on PD therapy are reported. Peptides, alkaloids, quinones, terpenes, polysaccharides, polyphenols, lipids, pigments, and mycotoxins were isolated from those marine organisms. They can act in several PD hallmarks, reducing oxidative stress, preventing mitochondrial dysfunction, α-synuclein aggregation, and blocking inflammatory pathways through the inhibition translocation of NF-kB factor, reduction of human tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6). This review gathers the marine natural products that have shown pharmacological activities acting on targets belonging to different intracellular signaling pathways related to PD development, which should be considered for future pre-clinical studies.
Obsidian Artifacts from Multiple Sources and Subsources at Valdesi in Western Sicily
Authors: Tykot Robert H. , Forgia Vincenza , Foresta Martin Franco
Published: August 2023

Forty-two obsidian artifacts excavated at the site of Valdesi in western Sicily were analyzed to determine their geological sources and to reconstruct trade patterns. Non-destructive analysis was performed using a portable, non-destructive X-ray fluorescence spectrometer, with the calibrated element’s composition values compared directly with a dataset of geological samples from the Mediterranean and European sources that were analyzed with the same instrument. The results, based on straightforward X-Y graphs using the trace elements Rb, Sr, Y, Zr, and Nb, showed the presence of obsidian from two subsources on Lipari (Gabellotto Gorge, Canneto Dentro), two on Pantelleria (Balata dei Turchi, Lago di Venere), and one on Sardinia. The majority coming from Lipari coincided with the location of Valdesi, and nearly 20% came from Pantelleria, both consistent with the overall distribution patterns for Sicily, while the one from Sardinia is a unique discovery. These results are discussed in terms of the time period and context for Valdesi, as well as the open-water and land-based routes that must have been taken.
Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives
Authors: Biţă Andrei , Scorei Ion Romulus , Ciocîlteu Maria Viorica , Nicolaescu Oana Elena , Pîrvu Andreea Silvia , Bejenaru Ludovic Everard , Rău Gabriela , Bejenaru Cornelia , Radu Antonia , Neamţu Johny , Mogoşanu George Dan , Benner Steven A.
Published: August 2023

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD+) is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes. Further, healthy aging and longevity appear to be closely related to NAD+ and its related metabolites, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). As a dietary supplement, NR appears to be well tolerated, having better pharmacodynamics and greater potency. Unfortunately, NR is a reactive molecule, often unstable during its manufacturing, transport, and storage. Recently, work related to prebiotic chemistry discovered that NR borate is considerably more stable than NR itself. However, immediately upon consumption, the borate dissociates from the NR borate and is lost in the body through dilution and binding to other species, notably carbohydrates such as fructose and glucose. The NR left behind is expected to behave pharmacologically in ways identical to NR itself. This review provides a comprehensive summary (through Q1 of 2023) of the literature that makes the case for the consumption of NR as a dietary supplement. It then summarizes the challenges of delivering quality NR to consumers using standard synthesis, manufacture, shipping, and storage approaches. It concludes by outlining the advantages of NR borate in these processes.
Green Ultrasound-Assisted Synthesis of Rare-Earth-Based MOFs
Authors: Lo Presti Francesca , Pellegrino Anna L. , Consoli Nancy , Malandrino Graziella
Published: August 2023

Rare-earth (RE)-based metal organic frameworks (MOFs) are quickly gaining popularity as flexible functional materials in a variety of technological fields. These MOFs are useful for more than just conventional uses like gas sensors and catalyst materials; in fact, they also show significant promise in emerging technologies including photovoltaics, optical, and biomedical applications. Using yttrium and europium as ionic host centres and dopants, respectively, and 1,3,5-benzenetricarboxylic acid (H3-BTC) as an organic linker, we describe a simple and green approach for the fabrication of RE-MOFs. Specifically, Y-BTCs and Eu-doped Y-BTCs MOFs have been synthesised in a single step using an eco-friendly method that makes use of ultrasound technology. To establish a correlation between the morphological and structural properties and reaction conditions, a range of distinct reaction periods has been employed for the synthetic processes. Detailed analyses of the synthesised samples through powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FE-SEM), and Fourier-transform infrared spectroscopy (FT-IR) have confirmed the phase formation. Furthermore, thermal analyses such as thermogravimetric analysis (TGA) have been employed to evaluate the thermal stability and structural modifications of the Y-BTC and Eu-doped Y-BTC samples. Finally, the luminescent properties of the synthesised samples doped with Eu3+ have been assessed, providing an evaluation of their characteristics. As a proof of concept, an Eu-doped Y-BTC sample has been applied for the sensing of nitrobenzene as a molecule test of nitro derivatives.
Band Dynamics of Multimode Resonant Nanophotonic Lattices with Adjustable Liquid Interfaces
Authors: Razmjooei Nasrin , Magnusson Robert
Published: August 2023

Subwavelength resonant lattices offer a wide range of fascinating spectral phenomena under broadside illumination. The resonance mechanism relies on the generation of lateral Bloch modes that are phase matched to evanescent diffraction orders. The spectral properties and the total number of resonance states are governed by the structure of leaky modes and the mode count. This study investigates the effect of interface modifications on the band dynamics and bound-state transitions in guided-mode resonant lattices. We provide photonic lattices comprising rectangular Si3N4 rods with a liquid film with an adjustable boundary. The band structures and band flips are examined through numerical simulations using the rigorous coupled-wave analysis (RCWA) method and analyzing the zero-order spectral reflectance as a function of the incident angle. The band structures and band flips are examined through numerical simulations, and the influences of the refractive index and the thickness of the oil layer on the band dynamics are investigated. The results reveal distinct resonance linewidths corresponding to different refractive indices of the oil layer. Furthermore, the effect of the oil thickness on the band dynamics is explored, demonstrating precise control over the number of propagating modes within the lattice structure. Theoretical simulations and experimental results are presented for a subwavelength silicon-nitride lattice combined with a liquid film featuring an adjustable boundary. The presence of a relatively thick liquid waveguiding region enables the emergence of additional modes, including the first four transverse-electric (TE) leaky modes, which produce observable resonance signatures. Through experimental manipulation of the basic lattice’s duty cycle, the four bands undergo quantifiable band transitions and closures. The experimental results obtained within the 1400–1600 nm spectral range exhibit reasonable agreement with the numerical analysis. These findings underscore the significant role played by the interface in shaping the band dynamics of the lattice structure, providing valuable insights into the design and optimization of photonic lattices with adjustable interfaces.
Synthesis of Aluminum-Based Metal–Organic Framework (MOF)-Derived Carbon Nanomaterials and Their Water Adsorption Isotherm
Authors: Jeong Dasom , Kim Seong Cheon , An Taeseop , Lee Dongho , Hwang Haejin , Choi Siyoung Q. , Park Jeasung
Published: August 2023

The characteristics of water vapor adsorption depend on the structure, porosity, and functional groups of the material. Metal–organic framework (MOF)-derived carbon (MDC) is a novel material that exhibits a high specific area and tunable pore sizes by exploiting the stable structure and porosity of pure MOF materials. Herein, two types of aluminum-based MOFs were used as precursors to synthesize hydrophobic microporous C-MDC and micro-mesoporous A-MDC via carbonization and activation depending on the type of ligands in the precursors. C-MDC and A-MDC have different pore characteristics and exhibit distinct water adsorption properties. C-MDC with hydrophobic properties and micropores exhibited negligible water adsorption (108.54 mgg−1) at relatively low pressures (P/P0~0.3) but showed a rapid increase in water adsorption ability (475.7 mgg−1) at relative pressures of about 0.6. A comparison with the isotherm model indicated that the results were consistent with the theories, which include site filling at low relative pressure and pore filling at high relative pressure. In particular, the Do–Do model specialized for type 5 showed excellent agreement.
Taurine, a Component of the Tear Film, Exacerbates the Pathogenic Mechanisms of Acanthamoeba castellanii in the Ex Vivo Amoebic Keratitis Model
Authors: Salazar-Villatoro Lizbeth , Chávez-Munguía Bibiana , Guevara-Estrada Celia Esther , Lagunes-Guillén Anel , Hernández-Martínez Dolores , Castelan-Ramírez Ismael , Omaña-Molina Maritza
Published: August 2023

Acanthamoeba spp. is the etiological agent of amoebic keratitis. In this study, the effect of taurine in physiological concentrations in tears (195 μM) on trophozoites of Acanthamoeba castellanii through the ex vivo amoebic keratitis model was evaluated. Trophozoites were coincubated with the Syrian golden hamster cornea (Mesocricetus auratus) for 3 and 6 h. Group 1: Control (−). Corneas coincubated with amoebic culture medium and taurine. Group 2: Control (+). Corneas coincubated with trophozoites without taurine. Group 3: Corneas coincubated with taurine 15 min before adding trophozoites. Group 4: Trophozoites coincubated 15 min with taurine before placing them on the cornea. Group 5: Corneas coincubated for 15 min with trophozoites; subsequently, taurine was added. Results are similar for both times, as evaluated by scanning electron microscopy. As expected, in the corneas of Group 1, no alterations were observed in the corneal epithelium. In the corneas of Group 2, few adhered trophozoites were observed on the corneal surface initiating migrations through cell junctions as previously described; however, in corneas of Groups 3, 4 and 5, abundant trophozoites were observed, penetrating through different corneal cell areas, emitting food cups and destabilizing corneal surface in areas far from cell junctions. Significant differences were confirmed in trophozoites adherence coincubated with taurine (p < 0.05). Taurine does not prevent the adhesion and invasion of the amoebae, nor does it favor its detachment once these have adhered to the cornea, suggesting that taurine in the physiological concentrations found in tears stimulates pathogenic mechanisms of A. castellanii.
Use of Nanocarriers Containing Antitrypanosomal Drugs for the Treatment of Chagas Disease
Authors: Paiva Diogo de Freitas , Matos Ana Paula dos Santos , Garófalo Denise de Abreu , do Nascimento Tatielle , Monteiro Mariana Sato de Souza de Bustamante , Santos-Oliveira Ralph , Ricci-Junior Eduardo
Published: August 2023

Chagas disease, caused by the Trypanosoma cruzi parasitic protozoan, is a neglected tropical disease (NTD) of significant incidence in Latin America. Transmission to humans and other mammals is mainly via the vector insect from the Reduviidae family, popularly known as the kissing bug. There are other transmission means, such as through congenital transmission, blood transfusions, organ transplantations, and the consumption of contaminated food. For more than 50 years, the disease has been treated with benznidazole and nifurtimox, which are only effective during the acute phase of the disease. In addition to their low efficacy in the chronic phase, they cause many adverse effects and are somewhat selective. The use of nanocarriers has received significant attention due to their ability to encapsulate and release therapeutic agents in a controlled manner. Generally, their diameter ranges from 100 to 300 nanometers. The objective of this scoping review was to perform a search of the literature for the use of nanocarriers as an alternative for improving the treatment of Chagas disease and to suggest future research. Bibliographic searches were carried out in the Web of Science and PubMed scientific databases from January 2012 to May 2023, using the “Chagas disease and Trypanosoma cruzi and nanoparticles” keywords, seeking to gather the largest number of articles, which were evaluated using the inclusion and exclusion criteria. After analyzing the papers, the results showed that nanocarriers offer physiological stability and safety for the transport and controlled release of drugs. They can increase solubility and selectivity against the parasite. The in vitro assays showed that the trypanocidal activity of the drug was not impaired after encapsulation. In the in vivo assays, parasitemia reduction and high survival and cure rates in animals were obtained during both phases of the disease using lower doses when compared to the standard treatment. The scoping review showed that nanocarriers are a promising alternative for the treatment of Chagas disease.
Chemotherapy-Mediated Neuronal Aberration
Authors: Jaiswara Pradip Kumar , Shukla Surendra Kumar
Published: August 2023

Chemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the advancement of several modern therapies, such as immunotherapy, gene therapy, etc., chemotherapy remains the first-line therapy for most cancer patients. Along with its anti-cancerous effect, chemotherapy exhibits several detrimental consequences that restrict its efficacy and long-term utilization. Moreover, it effectively hampers the quality of life of cancer patients. Cancer patients receiving chemotherapeutic drugs suffer from neurological dysfunction, referred to as chemobrain, that includes cognitive and memory dysfunction and deficits in learning, reasoning, and concentration ability. Chemotherapy exhibits neurotoxicity by damaging the DNA in neurons by interfering with the DNA repair system and antioxidant machinery. In addition, chemotherapy also provokes inflammation by inducing the release of various pro-inflammatory cytokines, including NF-kB, IL-1β, IL-6, and TNF-α. The chemotherapy-mediated inflammation contributes to chemobrain in cancer patients. These inflammatory cytokines modulate several growth signaling pathways and reactive oxygen species homeostasis leading to systemic inflammation in the body. This review is an effort to summarize the available information which discusses the role of chemotherapy-induced inflammation in chemobrain and how it impacts different aspects of therapeutic outcome and the overall quality of life of the patient. Further, this article also discusses the potential of herbal-based remedies to overcome chemotherapy-mediated neuronal toxicity as well as to improve the quality of life of cancer patients.
The Impact of Continuous Veno-Venous Hemodiafiltration on the Efficacy of Administration of Prophylactic Doses of Enoxaparin: A Prospective Observational Study
Authors: Aszkiełowicz Aleksander , Steckiewicz Karol P. , Okrągły Michał , Wujtewicz Magdalena A. , Owczuk Radosław
Published: August 2023

Background: Critically ill patients frequently require continuous renal replacement therapy (CRRT). During CRRT, particles up to 10 kDa in size, such as enoxaparin, may be removed. The aim of this study was to determine if patients receiving prophylactic doses of enoxaparin and treated with continuous veno-venous hemodiafiltration (CVVHDF) reach prophylactic values of anti-Xa factor activity. Methods: In this observational trial, we compared two groups: 20 patients treated with CVVHDF and 20 patients not treated with CVVHDF. All of them received prophylactic doses of 40 mg of enoxaparin subcutaneously. Anti-Xa factor activity was determined on the third day of receiving a prophylactic dose of enoxaparin. The first blood sample was taken just before the administration of enoxaparin, and other samples were taken 3 h, 6 h, and 9 h after the administration of a prophylactic dose of enoxaparin. Results: At 3 and 6 h after administration of enoxaparin in both groups, we observed a significant increase in anti-Xa factor activity from baseline, with the peak after 3 h of administration. There were no significant differences in the numbers of patients who had anti-Xa factor activity within the prophylactic range between CVVHDF and control groups. Conclusion: CVVHDF has only a mild effect on the enoxaparin prophylactic effect measured by anti-Xa factor activity. Thus, it seems there is no need to increase the dose of enoxaparin for patients requiring CVVHDF.
Simultaneous Quantification and Visualization of Photosynthetic Pigments in Lycopersicon esculentum Mill. under Different Levels of Nitrogen Application with Visible-Near Infrared Hyperspectral Imaging Technology
Authors: Zhao Jiangui , Chen Ning , Zhu Tingyu , Zhao Xuerong , Yuan Ming , Wang Zhiqiang , Wang Guoliang , Li Zhiwei , Du Huiling
Published: August 2023

Leaf photosynthetic pigments play a crucial role in evaluating nutritional elements and physiological states. In facility agriculture, it is vital to rapidly and accurately obtain the pigment content and distribution of leaves to ensure precise water and fertilizer management. In our research, we utilized chlorophyll a (Chla), chlorophyll b (Chlb), total chlorophylls (Chls) and total carotenoids (Cars) as indicators to study the variations in the leaf positions of Lycopersicon esculentum Mill. Under 10 nitrogen concentration applications, a total of 2610 leaves (435 samples) were collected using visible-near infrared hyperspectral imaging (VNIR–HSI). In this study, a “coarse–fine” screening strategy was proposed using competitive adaptive reweighted sampling (CARS) and the iteratively retained informative variable (IRIV) algorithm to extract the characteristic wavelengths. Finally, simultaneous and quantitative models were established using partial least squares regression (PLSR). The CARS–IRIV–PLSR was used to create models to achieve a better prediction effect. The coefficient determination (R2), root mean square error (RMSE) and ratio performance deviation (RPD) were predicted to be 0.8240, 1.43 and 2.38 for Chla; 0.8391, 0.53 and 2.49 for Chlb; 0.7899, 2.24 and 2.18 for Chls; and 0.7577, 0.27 and 2.03 for Cars, respectively. The combination of these models with the pseudo-color image allowed for a visual inversion of the content and distribution of the pigment. These findings have important implications for guiding pigment distribution, nutrient diagnosis and fertilization decisions in plant growth management.
Effect of Different Monochromatic LEDs on the Environmental Adaptability of Spathiphyllum floribundum and Chrysanthemum morifolium
Authors: Song Yinglong , Liu Weichao , Wang Zheng , He Songlin , Jia Wenqing , Shen Yuxiao , Sun Yuke , Xu Yufeng , Wang Hongwei , Shang Wenqian
Published: August 2023

Light-emitting diodes (LEDs) can be programmed to provide specialized light sources and spectra for plant growth. UV-A (397.6 nm), blue (460.6 nm), green (520.7 nm), and red (661.9 nm) LED light sources were used to study the effects of different monochromatic lights on the growth, antioxidant system, and photosynthetic characteristics of Spathiphyllum floribundum ‘Tian Jiao’ (a shade-loving species) and Chrysanthemum morifolium ‘Huang Xiu Qiu’ (a sun-loving species). This research revealed that green and blue light could enhance the morphological indicators, Chl a/b, photosynthetic electron transfer chain performance, and photosystem activity of S. floribundum, blue and red light could enhance the solution protein, Chl a, and photosynthetic electron transfer chain performance of C. morifolium, red and UV-A light viewed the highest SOD and CAT activities of S. floribundum (275.56 U·min·g−1; 148.33 U·min·g−1) and C. morifolium (587.03 U·min·g−1; 98.33 U·min·g−1), respectively. Blue and green light were more suitable for the growth and development of the shade-loving plant S. floribundum, while red and blue light were more suitable for the sun-loving plant C. morifolium. UV-A light could be used for their stress research. The research revealed the different adaptation mechanism of different plants to light environmental conditions.
Ion Acoustic Breathers in Electron-Beam Plasma
Authors: Kaur Manveet , Singla Sunidhi , Saini Nareshpal Singh , Gill Fateh Singh
Published: August 2023

The nonlinear excitations of ion acoustic (IA) structures in an electron beam embedded plasma composed of Vasyliunas–Cairns (VC) distributed hot electrons has been studied. The nonlinear Schrödinger equation (NLSE) from the Kadomtsev–Petviashvili (KP) equation with suitable transformation has been derived from rational solutions of NLSE; breathers have been studied. It has been shown that the nonthermality and superthermality of the electrons, the electron beam density, and the beam velocity alter the characteristics of different kinds of breathers. This investigation may be important in interpreting the physics of nonlinear structures in the upper layer of magnetosphere.
End-Of-Use Fly Ash as an Effective Reinforcing Filler in Green Polymer Composites
Authors: Patsidis Anastasios C. , Souliotis Manolis
Published: August 2023

The aim of this study is to use fly ash powder in an environmentally friendly matrix, in a novel way, addressing environmental and disposal problems. Fly ash/epoxy composites were prepared and studied varying the filler content. An investigation of structural and morphological characteristics was conducted using of X-ray diffraction patterns and scanning electron microscopy images, which revealed the successful fabrication of composites. Thermomechanical properties were studied via dynamic mechanical analysis and static mechanical tests. The composites exhibited an improved mechanical response. Broadband dielectric spectroscopy was used to investigate the dielectric response of the composite systems over the frequency range from 10−1 to 107 Hz and the temperature range from 30 to 160 °C. The analysis revealed the presence of three relaxation processes in the spectra of the tested systems. Interfacial polarization, the glass-to-rubber transition of the polymer matrix, and the rearrangement of polar side groups along the polymer chain are the processes that occur under a descending relaxation time. It was found that dielectric permittivity increases with filler content. Finally, the influence of filler content and the applied voltage under dc conditions was analyzed to determine the ability of the composites to store and retrieve electric energy. Fly ash improved the efficiency of the storing/retrieving energy of the composites.
Impact of the Processing-Induced Orientation of Hexagonal Boron Nitride and Graphite on the Thermal Conductivity of Polyethylene Composites
Authors: Ali Mehamed , Sobolciak Patrik , Krupa Igor , Abdala Ahmed
Published: August 2023

Emergent heat transfer and thermal management applications require polymer composites with enhanced thermal conductivity (κ). Composites filled with non-spherical fillers, such as hexagonal boron nitride (hBN) and Graphite (Gr), suffer from processing-induced filler orientations, resulting in anisotropic κ, commonly low in the through-plane direction. Here, the effects of extrusion and compression molding-induced orientations on κ of hBN- and Gr-filled polyethylene composites were investigated. The effect of extrusion on the hBN orientation was studied using dies of various shapes. The shaped extrudates exhibited hBN orientations parallel to the extrusion flow direction, which prompted additional hBN orientation during compression molding. κ of the composites produced with shaped extrudates varied from 0.95 to 1.67 W m−1 K−1. Pelletizing and crushing the extrudates improved κ, by exploiting and eliminating the effect of extrusion-induced hBN orientations. Gr-filled composites showed better κ than hBN composites due to the higher intrinsic conductivity and bigger particle sizes. A maximum κ of 5.1 and 11.8 W m−1 K−1 was achieved in composites with oriented hBN and Gr through a thin rectangular die and stacking the sheets to fabricate composites with highly oriented fillers.
Conversion of Materials and Energy in Anaerobic Digestion of Sewage Sludge with High-Pressure Homogenization Pretreatment
Authors: Xiao Huihuang , Liang Jinsong , Zhang Yuxuan , Chang Jianning , Zhang Ru , Zhang Panyue
Published: August 2023

High pressure homogenization (HPH) pretreatment can improve sludge anaerobic digestion; however, the relationship among the material, energy conversion, and gas production efficiency was unclear under different operating conditions in sludge anaerobic digestion by HPH pretreatment. In this study, the performance of HPH pretreatment before sludge anaerobic digestion was investigated, and the relationship among the material, energy conversion, and gas production efficiency was explored. HPH pretreatment induced organic solubilization, and a maximum soluble chemical oxygen demand (SCOD)/total chemical oxygen demand (TCOD) of about 30% was achieved. Results showed that HPH pretreatment significantly improved the biogas production of sludge anaerobic digestion; the maximum increase in CH4 yield was 57%; and the anaerobic digestion period was shortened by about 10 days. The ratio of CH4 yield increment to volatile dissolved solids (VDS) increment was 0.21 mL/mg. The CH4 yield increment of 1 L/g volatile solid (VS) required a specific energy of 0.10 MJ/kg total solid (TS) by increasing the pressure with one cycle and 0.72 MJ/kg TS by increasing the cycle at 60 MPa. The minimum additive energy consumption of HPH pretreatment was 125 J/mL CH4 yield increment at 20 MPa with one cycle. Considering CH4 yield improvement and energy conservation, HPH pretreatment should maintain a pressure of no more than 60 MPa in one cycle. This study provides a theoretical reference for the practical application of HPH pretreatment in anaerobic digestion. HPH holds promise as a potential strategy for sewage sludge pretreatment to produce CH4 in anaerobic digestion.