bluuebunny/crossref_metadata_2025 huggingface dataset:
Management And Training Programs Of Military Drone Small Unmanned Aircraft Systems
Authors: Roberts Eric , Beck Andrew
Published: September 2017

The present study investigated the operational readiness of Army unmanned aircraft systems (UAS) training programs. Small unmanned aircraft systems (SUAS), unlike larger UAS, are not managed by the Aviation branch within the Army. They are managed and employed by Infantry branch unit personnel. The differences in organizational culture and methods between the Infantry and Aviation could pose challenges for safe SUAS utilization. This study found that the majority of SUAS operators were not meeting flight currency requirements as per Army regulation. A high number of respondents believed that SUAS would be more effectively and safely employed if SUAS was its own military occupational specialty (MOS) and was managed by Aviation branch. This study helps us to understand the occupational demands of unmanned aircraft systems warrant consideration of a SUAS MOS, which is branched in Aviation.
Medication Management Apps: Usable by Older Adults?
Authors: Stuck Rachel E. , Chong Amy W. , Tracy L. Mitzner , Rogers Wendy A.
Published: September 2017

For older adults, managing medications can be a burden and could lead to medication non-adherence. To decrease risks associated with medication non-adherence, healthcare providers may recommend medication reminder apps as an assistive tool. However, these apps are often not designed with consideration of older adults’ needs, capabilities, and limitations. To identify whether available apps are suitable for older adults, we conducted an in-depth cognitive walkthrough and a heuristic evaluation of the most commonly downloaded medication reminder app. Findings revealed three main issues: 1) difficulty in navigation, 2) poor visibility, and 3) a lack of transparency. We also selected the top five downloaded medication reminder apps and categorized user reviews to assess app functionality and usability problems. The results of our analysis provide guidance for app design for older adult users to provide effective tools for managing medications and supporting patient/user health.
Developing A Theoretical Framework of Task Complexity for Research on Visualization in Support of Decision Making Under Uncertainty
Authors: Fiore Stephen M. , Warta Samantha F. , Best Andrew , Newton Olivia , LaViola Joseph J.
Published: September 2017

This paper describes initial validation of a theoretical framework to support research on the visualization of uncertainty. Two experiments replicated and extended this framework, illustrating how the manipulation of task complexity produces differences in performance. Additionally, using a combinatory metric of workload and performance, this framework provides a new metric for assessing uncertainty visualization. We describe how this work acts as a theoretical scaffold for examining differing forms of visualizations of uncertainty by providing a means for systematic variations in task context.
What Does A Robot Look Like?: A Multi-Site Examination of User Expectations About Robot Appearance
Authors: Phillips Elizabeth , Ullman Daniel , de Graaf Maartje M. A. , Malle Bertram F.
Published: September 2017

Robot design is a critical component of human-robot interaction. A robot’s appearance shapes people’s expectations of that robot, which in turn affect human-robot interaction. This paper reports on an exploratory analysis of 155 drawings of robots that were collected across three studies. The purpose was to gain a better understanding of people’s a priori expectations about the appearance of robots across a variety of robot types (household, military, humanoid, generic, and AI). The findings suggest that people’s visualizations of robots have common features that can be grouped into five broad components. People seem to distinguish between human-like and machine-like robots, with a default visualization of robots having a human-like appearance. In addition, expectations about robot appearance may be dependent on application domain.
Are All Types of Natural Environments Created Equal? A Comparison of Different Elements in Nature for Improving Restoration in Work Environments
Authors: Neilson Brittany , Nguyen Theresa , Bukowski Alex , Klein Martina
Published: September 2017

Prior research suggested images that feature aquatic elements were perceived to be more restorative. Specifically, images with a larger proportion of aquatic elements compared to greenery elements were more restorative than images that contained just greenery elements. This idea has been referred to as the “dose effect” of water. However, related work was not able to extend these results, leading to questions about the validity of the effect. The current study was conducted to determine whether we could replicate the “dose effect” using the same images as previous researchers and whether we could generalize the “dose effect” to a unique set of images. Our results indicated that we were unable to replicate the “dose effect” using the same images utilized in prior research, and we were also unable to generalize it to a unique set of images.
Performance analysis of a satellite–multi-terrestrial relay network with hardware impairments using switch-and-stay combining scheme
Authors: Guo Kefeng , Zhang Bangning , Huang Yuzhen , Guo Daoxing
Published: September 2017

Space information networks are proposed to broaden the observation area and realize continuous information acquisition using satellites and high-altitude platform stations. Space information networks are able to enhance detection and transmission capabilities compared to the current single Earth observation satellite. The satellite–terrestrial network is an important component of the space information networks. Hence, the major contribution of this article is to propose a new transmitted link selection scheme in a satellite–terrestrial network. Switch-and-stay combining scheme is used by destination to have a trade-off between the complexity and efficiency. The satellite, terrestrial relays, and destination user are influenced by hardware impairments, respectively. The closed-form expressions for the outage probability and throughput are derived. In order to analyze the system performance at high signal-to-noise rate, the asymptotic expressions for the system performance are also derived to give a special view on the impact of hardware impairments on the considered network. What is more, numerical results are derived to verify the correctness of our analytical results.
An efficient reconfigurable ad-hoc algorithm for multi-sink wireless sensor networks
Authors: Carlos-Mancilla Miriam , López-Mellado Ernesto , Siller Mario , Fapojuwo Abraham
Published: September 2017

This article presents a novel distributed protocol for wireless sensor network formation and operation in multi-sink environments. It consists of three stages: the first one performs network formation and maintenance under a policy of low power consumption based on a local strategy in which every sensor node in the environment interacts only with the neighbour nodes. The second one uses local information to build trees from the sink nodes using a load balance strategy. In the third stage, the sinks collect sensed data through the trees. The protocol has been modelled by a timed Petri net, which is used first for a qualitative validation in which deadlocks, operational functionality, overflows, bottlenecks, and delays were checked, and later for network performance analysis.
The use of thoracic stent grafts for endovascular repair of abdominal aortic aneurysms
Authors: Bastiaenen VP , Snoeijs MGJ , Blomjous JGAM , Bosma J , Leijdekkers VJ , van Nieuwenhuizen RC , Vahl AC
Published: September 2017

Objectives

Stent grafts for endovascular repair of infrarenal aneurysms are commercially available for aortic necks up to 32 mm in diameter. The aim of this study was to evaluate the feasibility of endovascular repair with large thoracic stent grafts in the infrarenal position to obtain adequate proximal seal in wider necks.

Methods

All patients who underwent endovascular aneurysm repair using thoracic stent grafts with diameters greater than 36 mm between 2012 and 2016 were included. Follow-up consisted of CT angiography after six weeks and annual duplex thereafter.

Results

Eleven patients with wide infrarenal aortic necks received endovascular repair with thoracic stent grafts. The median diameter of the aneurysms was 60 mm (range 52–78 mm) and the median aortic neck diameter was 37 mm (range 28–43 mm). Thoracic stent grafts were oversized by a median of 14% (range 2–43%). On completion angiography, one type I and two type II endoleaks were observed but did not require reintervention. One patient experienced graft migration with aneurysm sac expansion and needed conversion to open repair. Median follow-up time was 14 months (range 2–53 months), during which three patients died, including one aneurysm-related death.

Conclusions

Endovascular repair using thoracic stent grafts for patients with wide aortic necks is feasible. In these patients, the technique may be a reasonable alternative to complex endovascular repair with fenestrated, branched, or chimney grafts. However, more experience and longer follow-up are required to determine its position within the endovascular armamentarium.
Worldview Conflict in Daily Life
Authors: Brandt Mark J. , Crawford Jarret T. , Van Tongeren Daryl R.
Published: September 2017

Building on laboratory- and survey-based research probing the psychology of ideology and the experience of worldview conflict, we examined the association between worldview conflict and emotional reactions, psychological well-being, humanity esteem, and political ideology in everyday life using experience sampling. In three combined samples (total N = 328), experiencing disagreement compared to agreement was associated with experiencing more other-condemning emotions, less well-being, and less humanity esteem. There were no clear associations between experiencing disagreement and experiencing self-conscious emotions, positive emotions, and mental stress. None of the relationships were moderated by political ideology. These results both replicate and challenge findings from laboratory- and survey-based research, and we discuss possible reasons for the discrepancies. Experience sampling methods can help researchers get a glimpse into everyday worldview conflict.
Catheter‐directed therapy for submassive pulmonary embolism after unsuccessful systemic thrombolysis
Authors: Dong Chang , Jiang Shufen , Ji Donghua , Ji Yingqun , Zhang Zhonghe
Published: September 2017

Catheter‐directed therapy (CDT) has emerged as an important treatment for pulmonary embolism (PE). We present a patient with life‐threatening submassive PE with transient hypotension, progressive right ventricular dysfunction, and respiratory failure who failed anticoagulation and had little improvement with systemic thrombolysis, but responded well to catheter‐directed therapy.
President's Page
Authors: House Nancy
Published: September 2017

Recent natural disasters in Houston and other parts of the world have adversely affected many members and sponsors of SEG. The economic impact of these disasters on individual communities and countries, on the petroleum industry (which was already suffering from excess supply and changing demand for geophysics), and on SEG is huge. Hurricanes Harvey and Irma, the 7 September earthquake that struck off the southern coast of Mexico, and disasters in other parts of the world highlight an expanding role of geophysics and other sciences to help prepare for and mitigate such events in the future. Many of the future mitigation and warning processes are already SEG programs (e.g., Geoscientists Without Borders® [GWB]) or fall within the domain of technical groups (e.g., the Near Surface Technical Section).
Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population
Authors: Glans Martin , Bejerot Susanne , Humble Mats B.
Published: September 2017

Background

Generalised joint hypermobility (GJH) is reportedly overrepresented among clinical cases of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and developmental coordination disorder (DCD). It is unknown if these associations are dimensional and, therefore, also relevant among non-clinical populations.

Aims

To investigate if GJH correlates with sub-syndromal neurodevelopmental symptoms in a normal population.

Method

Hakim-Grahame's 5-part questionnaire (5PQ) on GJH, neuropsychiatric screening scales measuring ADHD and ASD traits, and a DCD-related question concerning clumsiness were distributed to a non-clinical, adult, Swedish population (n=1039).

Results

In total, 887 individuals met our entry criteria. We found no associations between GJH and sub-syndromal symptoms of ADHD, ASD or DCD.

Conclusions

Although GJH is overrepresented in clinical cases with neurodevelopmental disorders, such an association seems absent in a normal population. Thus, if GJH serves as a biomarker cutting across diagnostic boundaries, this association is presumably limited to clinical populations.
Perceptions and knowledge of antipsychotics among mental health professionals and patients
Authors: Cahling Lindah , Berntsson Anders , Bröms Gabriella , Öhrmalm Lars
Published: October 2017

Aims and method

To assess the patients' most influential concerns regarding long-acting injectable antipsychotics (LAIs) and mental health professionals' preconceptions about these concerns. For both groups, to assess the level of knowledge about LAIs. This cross-sectional study used semi-structured interviews of patients with schizophrenia or schizoaffective disorder (n = 164), nurses (n = 43) and physicians (n = 20).

Results

The mental health professionals overestimated many of the patients' fears of LAIs, and the expressed fears exceeded the actual experiences of patients already on LAIs. Acceptance to switch to LAIs was associated with shorter time from diagnosis. Nurses and patients disclosed limited knowledge of antipsychotics.

Clinical implications

Physicians and nurses should aim to identify the individual patient's concerns about LAIs in the discussion about choice of antipsychotic treatment early in the course of illness.
Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin
Authors: Gao Juan , Huang Ming , Lai Jingjing , Mao Kaijun , Sun Peisen , Cao Zhongyuan , Hu Youpei , Zhang Yingying , Schulte Marie L. , Jin Chaozhi , Wang Jian , White Gilbert C. , Xu Zhen , Ma Yan-Qing
Published: September 2017

Kindlins play an important role in supporting integrin activation by cooperating with talin; however, the mechanistic details remain unclear. Here, we show that kindlins interacted directly with paxillin and that this interaction could support integrin αIIbβ3 activation. An exposed loop in the N-terminal F0 subdomain of kindlins was involved in mediating the interaction. Disruption of kindlin binding to paxillin by structure-based mutations significantly impaired the function of kindlins in supporting integrin αIIbβ3 activation. Both kindlin and talin were required for paxillin to enhance integrin activation. Interestingly, a direct interaction between paxillin and the talin head domain was also detectable. Mechanistically, paxillin, together with kindlin, was able to promote the binding of the talin head domain to integrin, suggesting that paxillin complexes with kindlin and talin to strengthen integrin activation. Specifically, we observed that crosstalk between kindlin-3 and the paxillin family in mouse platelets was involved in supporting integrin αIIbβ3 activation and in vivo platelet thrombus formation. Taken together, our findings uncover a novel mechanism by which kindlin supports integrin αIIbβ3 activation, which might be beneficial for developing safer anti-thrombotic therapies.
Elastic ankle muscle-tendon interactions are adjusted to produce acceleration during walking in humans
Authors: Farris Dominic James , Raiteri Brent James
Published: September 2017

Humans and other cursorial mammals have distal leg muscles with high in-series compliance that aid locomotor economy. This muscle-tendon design is considered sub-optimal for injecting net positive mechanical work. However, humans change speed frequently when walking and any acceleration requires net positive ankle work. The present study unveiled how the muscle-tendon interaction of human ankle plantar flexors are adjusted and integrated with body mechanics to provide net positive work during accelerative walking. We found that for accelerative walking, a greater amount of active plantar flexor fascicle shortening early in the stance phase occurred and was transitioned through series elastic tissue stretch and recoil. Reorientation of the leg during early stance for acceleration allowed the ankle and whole soleus muscle-tendon complex to remain isometric while its fascicles actively shortened, stretching in-series elastic tissues for subsequent recoil and net positive joint work. This muscle-tendon behaviour is fundamentally different to constant speed walking, where the ankle and soleus muscle-tendon complex undergo a period of negative work to store energy in series elastic tissues before subsequent recoil, minimising net joint work. Muscles with high in-series compliance can therefore contribute to net positive work for accelerative walking and here we show a mechanism for how in human ankle muscles.
Information technology in the modeling of fast nonlinear processes (on the example of interaction of submunitions with biological tissue)
Authors: Гусев Андрей , Gusev Andrey , Шабанов Геннадий , Shabanov Gennadiy , Родионов Михаил , Rodionov Mihail
Published: September 2017

The monograph is devoted to the problem of mathematical modeling of process of interaction of the bullet with the block simulator with a finite element method that enables the assessment of the damaging effect of bullets at the design stage, the development of neural network based on the evaluation of those factors on the parameters of the damaging effect of bullets provides a characterization of the striking element on the stages of the pilot study, conceptual design and technical design and development of methods for the assessment of the damaging effect of bullets of small arms ammunition, taking into account elastico viscous state of the target.
Ensuring human rights in activities of law enforcement agencies
Authors: Акмалова Альфия , Akmalova Alfiya , Капицын Владимир , Kapitsyn Vladimir
Published: September 2017

In the textbook on the basis of consideration of international standards and national legislation in the field of the rights and freedoms of the individual are considered main mechanisms of their law-enforcement agencies. Special attention is paid to the analysis of the requirements to the law enforcement practice of public authorities concerning the rights of separate categories of citizens.
The tutorial is intended for professionals studying in the direction of training "law Enforcement" and anyone involved in human rights activities, asked about the situation of the individual in society and the state.
EFFECT OF HEAT TREATMENT ON THE CORROSION BEHAVIOR OF Al-10%WT Mg ALLOYS
Authors: Samira Zermane , Abdelouahed Chala , Okba Belahssen
Published: September 2017

In the present investigation, the effect of heat treatment on the electrochemical behavior of Al-10% wt Mg alloy in 3.5% wt NaCl is studied by different electrochemical techniques such as polarization technique (Tafel plot) and electrochemical impedance spectroscopy. It has been shown that the corrosion resistant of the alloy decreased with the ageing treatment at 250 °C for 24 h. However, this latter increased with naturally ageing. The SEM (electron microscope) and Energy Dispersive EDS characterization have shown that the alloy with the two treatments of ageing became susceptible to the pitting corrosion.
SUPERPLASTIC DEFORMATION OF TWO PHASE MgLiAl ALLOY AFTER TCAP PRESSING
Authors: Dutkiewicz Jan , Rusz Stanislav , Kuc Dariusz , Hilser Ondrej , Pałka Paweł , Boczkal Grzegorz
Published: September 2017

Magnesium based alloy containing 9 wt. % Li, 1,5 wt. % Al, composed of  (hcp + bcc) phases was cast under argon atmosphere and extruded at 350oC as bars of cross section 12x12 mm. Twist Channel Angular Pressing TCAP deformation was applied at a temperature of 160oC using BC rotation of samples in the following passes. TCAP tool consisted of helical part in horizontal area of the channel with an angle of lead γ = 30° to simulate back pressure and thus to increase the extrusion force. The initial grain size of the hexagonal  phase estimated at 30 m decreased in the following passes down to 6 m and that of bcc  phase decreased after TCAP from initial 12 m, down to 5 m. TEM studies after TCAP passes showed higher dislocation density in the  region than in the  phase. Crystallographic relationship (001)  || (110)  indicates parallel positioning of slip planes of both phases due to activation of slip. Electron diffraction indicates increase of grain misorientation with a number of TCAP passes. Stress/strain curves measured at temperature of 200oC show superplastic forming after 1st and 3rd TCAP passes with better superplastic properties with increasing number of passes. Values of strain rate sensitivity coefficient m were calculated at 0.31 after 1 TCAP pass using flow stress values from step strain increase curves. The sample after 3 TCAP passes showed increase of m value up to 0.47 for the strain rate range 10-5 – 5 x 10-4 s-1. Obtained values are slightly lower than those reported in the literature, however increase of a number of TCAP passes has a positive effect on superplastic properties due to fine grains and increase of their misorientation.
Contents
Authors: AMS Editorial
Published: September 2017

Research papers

Technical notes
Demands on community nurse mentors: Are new models for practice necessary?
Authors: Ball Judith
Published: September 2017

The Royal College of Nursing (RCN) Bazian report (2015a) explored international mentorship models that focus less on 1:1 mentorship than on an increased ratio of students to a mentor, and this was used to inform the RCN (2015b) mentorship recommendations document to the Nursing and Midwifery Council (NMC). The need to examine new models for mentorship and make recommendations for future practice was identified, despite the Bazian report ( RCN, 2015a ) stating that among developed countries and national regulators and professional bodies, the UK seemed to possess the most detailed policy and guidance on student nurse mentoring. The models mentioned were not community nursing-focused, as this group of nurses visits people in their own homes. The need for new community mentorship models will be examined, alongside the need to support increasing numbers of student learners in practice, as the NMC is revisiting the Standards for Learning and Assessment in Practice ( NMC, 2008 ) and has provided draft guidance of forthcoming changes for mentors inviting comments, due to be refined and published 2018. This article will examine the challenges and benefits to community nursing of adopting new models of mentorship delivery.
Barriers deterring patient advocacy in a Saudi Arabian critical care setting
Authors: Mortell Manfred , Abdullah Khatijah L , Ahmad Chean
Published: September 2017

Aim:

To explore the perceptions of patient advocacy among Saudi Arabian intensive care unit (ICU) nurses.

Background:

Despite advocacy being a crucial role for nurses, its scope is often limited in clinical practice. Although numerous studies have identified barriers to patient advocacy, their recommendations for resolution were unclear.

Method:

The study employed a constructivist grounded theory methodology, with 13 Saudi Arabian registered nurses, working in critical care, in a tertiary academic teaching hospital. Semi-structured interviews, with broad open-ended questions, and reflective participant journals were used to collect data. All interviews were concurrently analysed and transcribed verbatim.

Results:

Gender, culture, education, subjugation, communal patronage, organisational support and repercussions, and role-associated risks were all revealed as factors affecting their ability to act as advocates for critically ill patients.

Conclusion:

Saudi Arabian ICU nurses in the study believed that advocacy is problematic. Despite attempting to advocate for their patients, they are unable to act to an optimal level, instead choosing avoidance of the potential risks associated with the role, or confrontation, which often had undesirable outcomes. Patient advocacy from a Saudi Arabian nursing perspective is contextually complex, controversial and remains uncertain. Further research is needed to ensure patient safety is supported by nurses as effective advocates.
UK district nursing: the crisis continues
Authors: Glasper Alan
Published: September 2017

Emeritus Professor Alan Glasper, from the University of Southampton, discusses a new independent report that warns of the problems facing district nursing and its effect on the care home sector and acute NHS care
Assurance from ward to board
Authors: Foster Sam
Published: September 2017

Sam Foster, Chief Nurse, Oxford University Hospitals, has started a new job and plans to work with her new team to ensure the best post possible care is being delivered to patients
O Coaching como Ferramenta na Formação de Liderança nas Organizações Comerciais: Estudo de Caso em uma Empresa de Juazeiro do Norte
Authors: Luna Matheus De Medeiros , Almeida Neto José Leandro , Maranhão Thércia Lucena Grangeiro , Souza Franscisca Laudeci Martins
Published: October 2017

O presente trabalho tem por objetivo conhecer a importância do Coaching como ferramenta no desenvolvimento da liderança, bem como a aplicação de processos de Coaching no âmbito organizacional e como a liderança e o Coaching estão interligados. Buscando entender como esses procedimentos podem auxilia no desenvolvimento de competências das organizações. Será feito um estudo de caso em uma dada empresa na cidade de Juazeiro do Norte, composta por 26 funcionários. A empresa já existiu há 10 anos, retornando no mês de outubro de 2012. Tendo por volta de três anos e meio de existência. Nessa empresa existem práticas de treinamento para os gerentes, tanto on-line quanto presenciais, a fim de desenvolver os gerentes para que possa treinar a equipe. Quanto às bases lógicas de investigação, método da pesquisa foi hipotético dedutivo. Será aplicado um questionário para os colaboradores e entrevista para o gestor.  Ao realizar o trabalho foram utilizadas pesquisas bibliográficas, textos em sites e artigos científicos. Ao término do trabalho ficou comprovado que o Coaching é considerada ferramenta de auxílio de liderança, potencializando assim as habilidades e maximização de resultados.
A CIDADE COMO PROCESSO CORPOGRÁFICO: CORPO E PALAVRA
Authors: Santos Taís Beltrame dos , Allemand Débora Souto
Published: September 2017

O artigo retrata o processo e pontual experiência de uma futura arquiteta e sempre bailarina, que procura na cidade os motivadores criativos de suas composições. De modo a ressignificar o cotidiano por meio de leituras urbanas, procura estabelecer conexões entre criação, corpo, espaço, escala, visualidades e cidade. Permeia campos multidisciplinares e não limitados, de forma a encontrar pequenas respostas para questionamentos cotidianos. Baseia-se nas possibilidades da cartografia, através da leitura dos processos pelo corpo e busca, através da crítica sensível, apreender a cidade e a si mesma. Esse processo tem como resultado uma sequência coreográfica, que recorre ao fim à poética e aos recursos descritivos e visuais das palavras. Conclui que a cidade não pode ser representada pelo corpo e que sua leitura é somente uma alusão pessoal aos fluxos que a qualificam.Palavras-chave: Corpografias urbanas, dança, arquitetura.
Dez quadras ao redor do estúdio
Authors: Nunes Gustavo De Oliveira
Published: September 2017

Resenha do Catálogo de Exposicção Dez quadras ao redor do estúdio, do artista belga radicado no México Francis Alÿs.
Kallmann syndrome and ichthyosis: a case of contiguous gene deletion syndrome
Authors: Berges-Raso Irene , Giménez-Palop Olga , Gabau Elisabeth , Capel Ismael , Caixàs Assumpta , Rigla Mercedes
Published: September 2017

Kallmann syndrome is a genetically heterogeneous form of hypogonadotropic hypogonadism caused by gonadotropin-releasing hormone deficiency and characterized by anosmia or hyposmia due to hypoplasia of the olfactory bulbs; osteoporosis and metabolic syndrome can develop due to longstanding untreated hypogonadism. Kallmann syndrome affects 1 in 10 000 men and 1 in 50 000 women. Defects in 17 genes, includingKAL1, have been implicated. Kallmann syndrome can be associated with X-linked ichthyosis, a skin disorder characterized by early onset dark, dry, irregular scales affecting the limb and trunk, caused by a defect of the steroid sulfatase gene (STS). BothKAL1andSTSare located in the Xp22.3 region; therefore, deletions in this region cause a contiguous gene syndrome. We report the case of a 32-year-old man with ichthyosis referred for evaluation of excessive height (2.07 m) and weight (BMI: 29.6 kg/m2), microgenitalia and absence of secondary sex characteristics. We diagnosed Kallmann syndrome with ichthyosis due to a deletion in Xp22.3, a rare phenomenon.

Learning points:

Kallmann syndrome is a genetically heterogeneous disease characterized by hypogonadotropic hypogonadism with anosmia or hyposmia associated with defects in the production or action of gonadotropin-releasing hormone (GnRH) and hypoplasia of the olfactory bulbs.

Several genes have been implicated in Kallmann syndrome, includingKAL1, located in the Xp22.3 region, which is responsible for X-linked Kallmann syndrome.KAL1encodes the protein anosmin-1. X-linked ichthyosis is caused by deficiency of the steroid sulfatase enzyme, encoded bySTS, which is also located in the Xp22.3 region. Deletions involving this region can affect both genes and result in contiguous gene syndromes.

Phenotype can guide clinicians toward suspicion of a specific genetic mutation.KAL1mutations are mostly related to microgenitalia, unilateral renal agenesis and synkinesia, although patients need not present all these abnormalities.

Longstanding untreated hypogonadism is associated with poor sexual health, osteoporosis and metabolic syndrome with the concomitant risk of developing type 2 diabetes mellitus and obesity.

Treatment aims to promote the development of secondary sex characteristics, build and sustain normal bone and muscle mass and restore fertility. Treatment can also help minimize some psychological consequences.

Treatments available for patients with congenital GnRH deficiency such as Kallmann syndrome include gonadal steroid hormones, human gonadotropins and GnRH. The choice of therapy depends on the goal or goals.
El fracaso del estanco de la pimienta en Castilla, 1605-1684
Authors: Alloza Aparicio Ángel
Published: September 2017

Este trabajo reconstruye el estanco de la pimienta en Castilla durante el siglo XVII. Lo hace con fuentes primarias no estudiadas hasta la fecha, predominantemente de carácter fiscal. En él se aprecia la extensión del consumo de esta especia en la sociedad castellana, su utilización para fines recaudatorios y, tan revelador como lo anterior, la complejidad existente a la hora de establecer el monopolio sobre un producto de cuyo abastecimiento no se posee el control directo ni absoluto. Finalmente, el modelo de gestión de las rentas de la Corona y la controversia entre su administración directa o su arrendamiento quedan perfectamente definidos en el trabajo: siendo inequívoca la preferencia por la gestión privada, siempre se opta por la opción más rentable.
Leísmo real y leísmo aparente. Sobre el uso de los pronombres átonos (le, les, la, las, lo, los) en Málaga
Authors: Díaz Montesinos Francisco
Published: September 2017

Este trabajo tiene por objetivo el estudio de los pronombres átonos de tercera persona no reflexivos en el corpus oral del español hablado en la ciudad de Málaga (España). Puesto que Málaga está ubicada en una zona dominada por el sistema distinguidor de caso, resulta interesante conocer qué verbos y qué estructuras presentan la variación dativo/acusativo. Para ello, se exponen primero los principios analíticos seguidos y se destaca la importancia del tipo de construcción en el uso del objeto directo-acusativo y del objeto indirecto-dativo. Después se proporcionan los porcentajes de uso de los clíticos pronominales y se analizan los verbos y construcciones en los que se atestiguan la variación o la alternancia. El resultado más relevante es la constatación del alto grado de conservadurismo lingüístico en lo referente al uso etimológico de los verbos y construcciones registrados, al mismo tiempo que se comprueba la existencia de un incipiente leísmo de persona masculino singular vinculado al nivel de estudios medios.
Deudas latinas y variaciones romances en la creación del marcador de topicalización respecto
Authors: Pons Rodríguez Lola
Published: September 2017

Las expresiones topicalizadoras se han configurado en romance y no han sido heredadas en tal funcionamiento desde la lengua madre, lo que las hace especialmente interesantes como muestras de la génesis y los detalles del desarrollo de las unidades que trabajan en la frontera entre lo oracional y lo discursivo.Este trabajo trata del uso de respecto como topicalizador en el español de ayer a partir de un esclarecimiento básico de cómo se usa hoy esta forma (§ 1). En § 2 describo la parentela románica de respecto en tanto que heredero de respectus y sus usos en neolatín, claves para entender la complejización formal que experimentó respecto en los romances. En § 3 se describe de acuerdo a su cronología las fases por las que pasó esta forma hasta hacerse, tardíamente, una expresión topicalizadora; y en § 4 se dan algunas notas acerca del complejo abigarramiento formal que ha presentado desde el castellano medieval al actual.
El marcado diferencial de la función 'meta' en español
Authors: Melis Chantal , Rodríguez Cortés Diego
Published: September 2017

El fenómeno conocido como ‘marcado diferencial’ de argumentos se manifiesta en la presencia de una marca casual particular que distingue unos referentes de otros en una determinada función, tal como sucede en español con los complementos directos que llevan la preposición a. El factor que más atención ha recibido en los intentos de explicar el fenómeno es la sabida ‘jerarquía de animación’, según la cual el marcado diferencial tiende a incidir en participantes que cumplen funciones no esperadas dada su posición en la jerarquía. Así, los seres humanos que actúan como ‘paciente’ en un evento, en lugar de tomar la función de agente que les corresponde, son los que más atraen la preposición a en español. En este trabajo, siguiendo nuevas vertientes de análisis, exploramos el marcado diferencial de la función locativa de ‘meta’ en español desde la perspectiva de los estudios tipológicos desarrollados en torno a este tema. Establecemos que el oficio de servir de punto de referencia espacial lo desempeñan canónicamente entidades inanimadas, de bajo rango jerárquico, y examinamos las formas de marcado diferencial que genera la asignación del papel de meta a una persona.
Métodos para medir la riqueza léxica de los textos. Revisión y propuesta
Authors: Torruella Casañas Joan , Capsada Blanch Ramon
Published: September 2017

Con el presente trabajo se pretende hacer una revisión extensa de los diferentes métodos existentes para medir la riqueza léxica de textos y hacer una propuesta para su aplicación a un corpus textual. En primer lugar, se da una visión de los principales índices existentes para cuantificar la riqueza léxica, explicando  cómo están definidos y evaluando sus fortalezas y sus debilidades a partir de actividades de carácter experimental. En segundo lugar, se plantea una propuesta de metodología de medición de la riqueza léxica para poderse utilizar en todo un corpus textual, de manera que se puedan establecer comparaciones entre textos y constituir una clasificación pautada del grado de riqueza léxica de cada uno de ellos dentro del conjunto del corpus.
Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in Caenorhabditis elegans
Authors: Underwood Ryan S , Deng Yuting , Greenwald Iva
Published: September 2017

Six initially equivalent, multipotential Vulval Precursor Cells (VPCs) in Caenorhabditis elegans adopt distinct cell fates in a precise spatial pattern, with each fate associated with transcription of different target genes. The pattern is centered on a cell that adopts the “1°” fate through Epidermal Growth Factor Receptor (EGFR) activity, and produces a lateral signal composed of ligands that activate LIN-12/Notch in the two flanking VPCs to cause them to adopt “2°” fate. Here, we investigate orthologs of a transcription complex that acts in mammalian EGFR signaling—lin-1/Elk1, sur-2/Med23, and the Cdk8 Kinase module (CKM)—previously implicated in aspects of 1° fate in C. elegans and show they act in different combinations for different processes for 2° fate. When EGFR is inactive, the CKM, but not SUR-2, helps to set a threshold for LIN-12/Notch activity in all VPCs. When EGFR is active, all three factors act to resist LIN-12/Notch, as revealed by the reduced ability of ectopically-activated LIN-12/Notch to activate target gene reporters. We show that overcoming this resistance in the 1° VPC leads to repression of lateral signal gene reporters, suggesting that resistance to LIN-12/Notch helps ensure that P6.p becomes a robust source of the lateral signal. In addition, we show that sur-2/Med23 and lin-1/Elk1, and not the CKM, are required to promote endocytic downregulation of LIN-12-GFP in the 1° VPC. Finally, our analysis using cell fate reporters reveals that both EGFR and LIN-12/Notch signal transduction pathways are active in all VPCs in lin-1/Elk1 mutants, and that lin-1/Elk1 is important for integrating EGFR and lin-12/Notch signaling inputs in the VPCs so that the proper gene complement is transcribed.
Tra-2 Mediates Cross-Talk Between Sex Determination and Wing Polyphenism in Female Nilaparvata lugens
Authors: Zhuo Ji-Chong , Lei Chen , Shi Ji-Kai , Xu Nan , Xue Wen-Hua , Zhang Meng-Qiu , Ren Ze-Wei , Zhang Hou-Hong , Zhang Chuan-Xi
Published: September 2017

Sexual dimorphism and wing polyphenism are important and evolutionarily conserved features of many insect species. In this article, we found a cross-talk linking sexual differentiation with wing polyphenism in the brown planthopper (BPH) Nilaparvata lugens (order: Hemiptera). Knockdown of the sex determination gene Transformer-2 in N. lugens (NlTra-2) in nymph caused females to develop into infertile pseudomales containing undeveloped ovaries. Whereas males treated with dsNlTra-2 exhibited normal morphology, but lost fertility. Knockdown of NlTra-2 in adult females (maternal RNAi) resulted in long-winged female offspring, indicating that maternal RNAi changed the wing morphs in female offspring. In addition, silencing of NlTra-2 down-regulated the expression of the forkhead transcription factor FoxO (NlFoxO), and simultaneously up-regulated the expression of phosphatidylinositol-3-OH kinase (PI(3)K)-protein kinase B (NlAkt), the two critical genes in the insulin signaling pathway. Furthermore, the long-winged effect caused by maternal dsNlTra-2 RNAi could be reversed by silencing of NlInR1 and NlAkt, leading to short-winged morphs. We propose that there is a cross-talk between the sexual differentiation and wing polyphenism pathways mediated by NlTra-2 during embryonic stages.
DARBO TEISĖS REKODIFIKAVIMAS LIETUVOJE 2016–2017 M.
Authors: Davulis Tomas
Published: September 2017

Straipsnyje yra siekiama atskleisti kokybiškai naujus darbo santykių teisinio reguliavimo bruožus, kurie jau netolimoje ateityje turės įtakos darbuotojų teisinei padėčiai Lietuvoje ir šalies darbo rinkos konkurencingumui. Todėl straipsnyje tiriamos ir analizuojamos Lietuvos darbo teisės rekodifikavimo priežastys ir paties naujojo Darbo kodekso kūrimo procesas. Pasitelkiant lyginamąjį, sisteminį ir kitus metodus, tiriamos Lietuvos naujojo Darbo kodekso nuostatos pagal bendrąsias kodekso, kaip teisės akto, charakteristikas ir pagal tai, kokius tikslus sau kėlė rekodifikavimo sumanytojai ir kaip jie buvo įgyvendinti įstatymo tekste.
SPRENDIMAS UŽ AKIŲ – AR RASTAS KOMPROMISAS?
Authors: Nekrošius Vytautas
Published: September 2017

Straipsnyje analizuojami Lietuvos Respublikos Seimo 2016 lapkričio 8 d. priimti CPK pakeitimai, susiję su sprendimo už akių instituto tobulinimu. Autorius stengiasi atsakyti į klausimą, ar jau ne vienerius metus trunkantis doktrinos atstovų ir praktikų ginčas dėl įrodymų vertinimo apimties, priimant sprendimą už akių, pagaliau išspręstas.
ŠIUOLAIKINIO KONSTITUCIONALIZMO SAMPRATA
Authors: Vaičaitis Vaidotas A.
Published: September 2017

Straipsnyje1 pateikiama konstitucionalizmo samprata, apimanti tris paradigmas: i) studijas apie skirtingas konstitucijos sąvokas, kuri čia vadinama filosofiniu konstitucionalizmu, ii) trijų pagrindinių konstitucinių vertybių (teisinės valstybės, demokratijos ir žmogaus teisių) tarpusavio santykį kaip vertybinį konstitucionalizmą ir iii) konstitucijos interpretavimo metodologijos teoriją, kuri čia vadinama interpretaciniu (metodologiniu) konstitucionalizmu. Kiekviena iš šių konstitucinių paradigmų galėtų apimti visą konstitucinės teisės turinį. Tokia konstitucionalizmo samprata yra visiškai naujas požiūris į konstitucionalizmo reiškinį ne tik Lietuvos, bet ir lyginamojoje konstitucinėje teisėje.
PACIENTO PAREIGA RŪPINTIS SAVO SVEIKATA KAIP TEISĖS Į SVEIKATOS PRIEŽIŪROS PASLAUGAS ĮGYVENDINIMO SĄLYGA
Authors: Januševičienė Justina
Published: September 2017

Straipsnyje aptariama pareigos rūpintis savo sveikata problematika argumentuojant, kad požiūris į šią prievolę ir deramą jos vykdymą turi keistis. Pareigą rūpintis savo sveikata reikia suvokti ne kaip deklaratyvią paciento atmintinės nuostatą, bet kaip vieną iš svarbiausių sąlygų paciento teisei į sveikatos priežiūros paslaugas atsirasti ir įgyvendinti. Socialinis spaudimas, skatinantis individą laikytis teisės normoje suformuluoto įpareigojimo, kyla tik tada, kai normos suvokiamos kaip svarbios, nes tikima, kad jos būtinos palaikyti socialinį gyvenimą.
The impact of allergic rhinitis on quality of life: a study in western Iran
Authors: Kalmarzi Rasoul Nasiri , Khazaei Zaher , Shahsavar Jafar , Gharibi Fardin , Tavakol Marzieh , Khazaei Salman , Shariat Mansoureh
Published: September 2017

Introduction: Chronic diseases, due to their prolonged and debilitating nature, dramatically affect patient quality of life. Allergic rhinitis (AR) is one of the most common chronic diseases. The present study aimed to determine quality of life in patients with allergic rhinitis in Western Iran.

Methods: In a cross-sectional study, 146 patients with AR were enrolled in this study. The required data were collected using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ). The questionnaire was distributed among the patients by a physician and analysis of data was carried out by SPSS version 16.

Results: Of the total of 146 AR patients admitted to the clinic, 61% were female and 39% were male; the mean age was 29±10.17. Rhinorrhea (82.2%) was the most common symptom, and moderate to severe intermittent rhinitis (38.4%) was the most common type of the disease. A dramatic reduction in quality of life was observed in 62% of the patients, and the severity of the disease significantly reduced the quality of life (P=0.000).

Conclusion: Allergic rhinitis can adversely affect every aspect of a patient's life, including sleep quality, mood and daily activities.
Essentials of bladder cancer worldwide: incidence, mortality rate and risk factors
Authors: Gandomani Hamidreza Sadeghi , Tarazoj Abed Asgari , Siri Fatemeh Hadavand , Rozveh Ali Karimi , Hosseini Soheila , Borujeni Narges Naseri , Mohammadian-Hafshejani Abdollah , Salehiniya Hamid
Published: September 2017

Bladder cancer (BC) is the sixth most common cancer in the world. An increase in the incidence and recurrence of BC has led to massive pressure on health care systems. Studies have shown that the geographical and ethical distributions of BC are variable in different parts of the world. However, most studies have focused more on clinical challenges and treatment strategies in BC management. Due to the limited number of studies conducted on the incidence rate, mortality and risk factors of BC worldwide, it is necessary to carry out studies in these areas. Therefore, the aim of this study was to determine the global incidence rate, mortality rate and risk factors for BC.
Physiological and psychological correlates of attention-related body sensations (tingling and warmth)
Authors: Tihanyi BT , Köteles F
Published: September 2017

Body sensations play an essential role in the subjective evaluation of our physical health, illness, and healing. They are impacted by peripheral somatic and external processes, but they are also heavily modulated by mental processes, e.g., attention, motor control, and emotion. Body sensations, such as tingling, numbness, pulse, and warmth, can emerge due to simply focusing attention on a body part. It is however an open question, if these sensations are connected with actual peripheral changes or happen “only in the mind.” Here, we first tested whether the intensity of such attention-related body sensations is related to autonomic and somatomotor physiological processes and to psychological traits. In this study, attention-related body sensations were not significantly connected to changes in physiology, except warmth sensation, which was linked to decrease in muscle tension. Overall intensity of tingling significantly correlated with body awareness and tendentiously with body–mind practice. This strengthened the hypothesis that attention-related body sensations are more the result of top–down functions, and the connection with peripheral processes is weak. Here, we suggested a novel protocol to examine the effect of manipulating attention on body sensations, which together with our results and discussion can inspire future researches.
PENAMBAHAN FILTER AIR PADA BUDIDAYA SISTEM YUMINA–BUMINA
Authors: Supendi Supendi , Maulana Muhammad Rizki , Fajar Samsul
Published: September 2017

Yumina-bumina adalah teknik budidaya yang memadukan antara sayuran (yu) dengan ikan (mina) atau buah-buahan (bu) dengan ikan (mina). Sayuran dalam yumina adalah tanaman sayuran daun. Adapun bumina adalah yang menghasilkan tanaman sayuran buah. Pada kegiatan ini dilakukan uji sistem yumina–bumina melalui penambahan filter air dengan perlakuan A (1 bak pengendapan), B (1 bak pengendapan 1 bak biofilter), C (2 bak pengendapan 1 bak biofilter). Tujuan dari kegiatan ini adalah untuk mendapatkan informasi efektivitas penambahan filter air dalam sistem yumina-bumina terhadap produksi ikan dan tanaman. Berdasarkan hasil pengamatan, biomassa panen terbesar diperoleh dari perlakuan C yang menghasilkan ikan 108,85 kg; pakcoi 466,67 g; caisin 266,67 g; kailan 300 g; tomat 853,33 g; dan terong 255 g.