bluuebunny/crossref_metadata_2025 huggingface dataset:
The Drug Effectiveness and Side Effects of Remdesivir in Neonatal COVID-19: A Case Series Study
Authors: Kazemian Mohammad , Nouripor Shamsollah , Alizadeh Parinaz , Saeidi Reza , Radfar Mitra , Tajalli Saleheh , Vafaee Ali , Mirrahimi Bahador , Fallahi Minoo
Published: February 2024

: Due to the novelty of COVID-19, no definite treatment has yet been found for this infectious disease, especially in neonates and early infants. Although most of the neonates affected by this virus have a mild or silent course of the disease, in the severe form, there is no approved antiviral drug. This study was done to evaluate the safety and efficacy of Remdesivir as the known effective antiviral drug in both adults and children’s populations. In this case series study, we present our experience of the administration of Remdesivir in the treatment of 15 infants with severe neonatal COVID-19, with severe respiratory distress, admitted to our neonatal intensive care unit. We prescribed the drug with a 2 to 3-hour infusion of a loading dose of 5 mg/kg on day 1, followed by 2.5 mg/kg/day 4 days later, concomitant with continuous cardiac monitoring and blood pressure monitoring every 15 minutes. Fortunately, no side effects were reported either during or after the administration of the drug. Long-term patient follows up, for 10 months after birth, did not reveal any particular complications. It seems that the use of Remdesivir to treat severe forms of neonatal and early infancy COVID-19 is safe and effective.
A Cross-sectional Study on the Role of Rotavirus and Microbial Co-infection in Children with Acute Diarrhea in Vietnam
Authors: Tran Khai Quang , Hoang Tuan Nguyen Hung , Pham Van Hung , Bui Nghia Quang , Kieu Anh Pham Tho , Ngo Toan Hoang , Minh Nguyen Phuong
Published: February 2024

Background: Rotavirus is the leading cause of acute diarrhea in children. Understanding co-infections with other bacterial or viral microorganisms alongside Rotavirus is crucial. Objectives: This study aimed to determine the frequency distribution of Rotavirus infections and related co-infections in children with acute diarrhea. Additionally, it sought to compare 2 groups: Those with Rotavirus mono-infection and those with microbial co-infections in terms of clinical and laboratory characteristics. Methods: In this cross-sectional study, we collected a total of 171 rectal swabs at Can Tho Children′s Hospital, Can Tho City, Vietnam, from November 2022 to April 2023. We used real-time polymerase chain reaction (PCR) to detect infectious agents. Patients underwent examinations and tests to assess clinical features and laboratory data. Results: Rotavirus was the most commonly detected agent (42.7%). The incidence of co-infection with other bacterial or viral microorganisms alongside Rotavirus was 45.2%. Acute diarrhea caused by Rotavirus significantly increased the percentage of children with watery stools (P = 0.004) and vomiting (P < 0.001) and led to a greater number of loose stools per day (P = 0.007) compared to cases without Rotavirus. However, there were no significant differences in clinical features or laboratory data between cases with Rotavirus mono-infection and those with co-infections involving other bacterial or viral microorganisms. Conclusions: This study sheds light on the prevalence of Rotavirus and co-infections in Vietnam. Among these findings, identifying Rotavirus in children with acute diarrhea is more critical than detecting co-infecting agents.
Patient-Reported Outcomes and Healthcare Practices: A Retrospective Analysis of Cystic Fibrosis Management During the COVID-19 Pandemic
Authors: Tabatabaii Seyed Ahmad , Taghizadeh-Behbahani Abdolhamid , Khanbabaee Ghamartaj , Alibakhshi Maryam , Bahadori Amir Reza , Farahbakhsh Nazanin
Published: February 2024

Background: Cystic fibrosis (CF) is one of the most prevalent inherited diseases in children. Coronavirus can lead to more severe respiratory complications in patients with comorbidities, such as CF. Additionally, the coronavirus disease 2019 (COVID-19) pandemic has imposed a substantial burden on both national and international healthcare systems. Coronavirus disease could influence CF patients’ morbidities and mortalities. Methods: A descriptive retrospective study was performed at Mofid Children's Hospital to determine the effect of the COVID-19 pandemic on CF patients. A physician completed 128 valid and reliable questionnaires. Moreover, hospital medical records were also used to revalidate the data and complete the remaining part of the questionnaire. The information collected for this study included demographic data, patients' height, patients' weight, body mass index (BMI), past and current positive history of COVID-19-like symptoms, socially determined condition, and influence of COVID-19 on routine therapeutic measurements in CF. The data were analyzed using SPSS software (version 21). Results: The majority of cases continued to perform chest physiotherapy at home, maintained routine follow-ups with pulmonologists, and adhered to their previous medication regimens (59.4%, 42.2%, and 82%, respectively). Moreover, 65.5% of participants reported leaving home less frequently than before, and approximately 73% of patients’ parents also reduced their outings, with no statistically significant differences (P > 0.05). Conclusions: The daily habits of CF patients did not undergo significant changes during the COVID-19 pandemic, particularly during the Omicron wave, despite the dramatic increase in infection rates.
Epigenetic Peculiarity of Alphapapillomavirus Genus Based on the CpG Dinucleotides’ Island Variability
Authors: Elisee Libert Embolo Enyegue , Christian Kitchener Ndipho Tatou , Halidou Awalou , Sidonie Agnès Ananga Noa , Mohamadou Halmata , Celestin Godwe , Honore Richard Eyebe , Basile Junior Evina Evina , Eric Michel Bell , Jean Louis Essame Oyono
Published: February 2024

Background: Methylation plays a crucial role in genome regulation, serving as an essential epigenetic mechanism. CpG islands, which are regions of DNA rich in CpG dinucleotides, are ubiquitous epigenetic regulatory features that can modulate the functional dynamics of genes, thereby influencing the pathophysiology of pathogenic organisms within a host. Objectives: In this study, we aimed to investigate the distribution of CpG islands on Papillomavirus genomes and assess their potential impact on the neoplastic progression of different Alphapapillomavirus genera within host cells. Methods: We conducted an analysis of dinucleotide frequencies in DNA sequences from various Alphapapillomavirus genera. The sequences for our analysis were sourced from the specialized HPV (human papillomavirus) database (pave.niaid.nih.gov). Following a comprehensive comparative examination of entire genomes from different HPV species, we specifically focused on 63 genomes belonging to the Alphapapillomavirus genus to identify internal CpG island profiles. These investigations were conducted using online bioinformatics software (DBCAT), and statistical analysis was performed using GraphPad Prism v. 8.0.1. Results: Our preliminary findings revealed that 76.1% of the viruses in our study had fewer than 3 CpG islands but multiple CpG sites, while fewer than 25% of the viruses possessed at least 3 CpG islands. High-risk viruses were identified in 68.42% of genotypes with fewer than 3 CpG islands, whereas low-risk genotypes were observed in 15.7% of cases. Notably, some oncogenic viruses lacked CpG islands entirely, and this pattern was also observed in viruses with a single CpG island, occurring in 50% of cases. Based on the absence of CpG islands, genotypes such as HPV 67, HPV 97, and HPV 34 could potentially be classified as carcinogenic. Additionally, the distribution of CpG islands across HPV genes did not appear to be random. Genes like L2 and E2 contained a CpG island in 50% of cases, whereas oncogenes E6 and E7 consistently had a CpG island in 100% of cases in high-risk genotypes. Conclusions: Our findings suggest that the loss of 1 or more CpG islands could potentially transform an HPV genotype into a high-risk genotype. This process may be accelerated in the presence of host-related risk factors. Further research is required to validate whether CpG island distribution can aid in identifying oncogenic viruses.
Preliminary Study on the Evaluation of Liver Fibrosis Using Endoscopic Ultrasound Elastography and Transabdominal Ultrasound Transient Elastography Combined with Strain Ratio
Authors: Yao Dun-Wei , Jiang Hai-Xing , Qin Shan-Yu
Published: February 2024

Background: This study aimed to explore the effectiveness of endoscopic ultrasound elastography (EUS-EG) in evaluating liver fibrosis. Methods: The present study involved 11 patients with chronic liver disease who met study criteria and underwent EUS-EG, transabdominal ultrasound transient elastography (TUS-TE), and liver biopsy (LB) examinations at the same time. The Batts-Ludwig scoring system for liver fibrosis was used as the gold standard to analyze the correlation between the EUS-EG strain ratio (SR) and TUS-TE liver stiffness measurement with the pathological stage of liver fibrosis. The optimal cut-off value and area under the receiver operating characteristic curve (AUROC) of EUS-EG and TUS-TE for diagnosing liver fibrosis were calculated by drawing an ROC curve, and the corresponding sensitivity, specificity, and accuracy were also calculated. Results: Endoscopic ultrasound elastography was highly positively correlated with the pathological stage of liver fibrosis (S ≥ 2, r = 0.759, P = 0.01), and TUS-TE was positively correlated with the pathological stage of liver fibrosis (S ≥ 2, r = 0.857, P = 0.003). The optimal diagnostic cut-off value of cirrhosis undergoing EUS-EG and TUS-TE was 0.84 and 14.2 Kpa, respectively. When the pathological stage was S0 - S1, the sensitivity, specificity, accuracy, and AUROC value of TUS-TE in the diagnosis of liver fibrosis were higher than those of EUS-EG (96.2%, 83.3%, 81.8%, and 0.96 vs. 94.6%, 75%, 72.7%, and 0.8958). When the pathological stage was ≥ S2, the sensitivity, specificity, accuracy, and AUROC values of EUS-EG were higher than those of TUS-TE (100%, 87.5%, 88.9%, and 0.97 vs. 100%, 83.3%, 88.9%, and 0.94). Conclusions: There is a superior correlation between EUS-EG combined with SR and the pathological stage of liver fibrosis, compared to TUS-TE, and it has the same or even higher diagnostic efficacy as TUS-TE. Larger prospective studies are needed to evaluate the clinical utility of this approach in the assessment of liver fibrosis.
Prevalence of Pain and Factors Affecting it in Patients with Lung Cancer in Ilam
Authors: Bastani Elham , Rizehbandi Mahsa , Shokri Fariba
Published: February 2024

Background: Pain has been known as one of the most common, persistent, and complex symptoms of patients with lung cancer. Objectives: The aim of this research is to study the relationship between attitude to pain and the prevalence and method of pain control in patients with lung cancer. Methods: This descriptive cross-sectional study was performed through the census method in patients suffering from lung cancer in Ilam Province. For data collection, while interviewing the patients and studying their files, instruments were used including demographic characteristics form, brief pain inventory, and pain attitude questionnaire. Data analysis was performed by SPSS v.16 through descriptive statistical tests (mean, percentage, and standard deviation) and analytical tests (independent t-test, ANOVA, and linear regression). Results: Considering the severity of pain, 12 (18.8%) patients had mild pain, 43 (67.2%) had moderate pain, and 9 (14.1%) had severe pain, and all of them reported some degree of pain. According to the findings, mean ± SD of the total score of the questionnaire was 77.15 (3.18), where the minimum and maximum acquired scores were 72 and 85, respectively. Also, no significant relationship was found between any of the dimensions of the attitude to pain questionnaire and the severity of pain. Further the mean ± SD of attitude to pain was 76.58 (2.81), 77.09 (3.28), and 78.22 (3.23) for mild, moderate, and severe pain, respectively. Conclusions: In this study, there was no relationship between pain severity and attitude to pain, which may have been due to the small sample size or the specificity of the study in the group of lung cancer patients. Accordingly, conducting further studies in this regard with a larger sample size is suggested.
Effect of Chitosan Nanoparticle on pfLA and ftsL Genes Expression in Listeria monocytogenes
Authors: Kazemi Rad Sara , Mirpour Mirsasan , Assmar Mehdi , Razavi Mohamad Reza
Published: February 2024

Background: Listeriosis is an infection caused by Listeria monocytogenes, a facultative, intracellular, Gram-positive bacterium. Listeriosis predominantly affects pregnant women and other high-risk groups. Listeria monocytogenes is a bacterium responsible for food-borne infections and is associated with serious illnesses, such as septicemia and encephalomeningitis. Chitosan nanoparticles (CNPs) are often used as nanomaterials due to their properties, such as antibacterial activity and non-toxic nature. Objectives: This research aimed to determine how the activity of cell division proteins and formate acetyltransferase-activating enzymes affect the expression of pfLA and ftsL genes in L. monocytogenes in response to CNPs. Methods: In this study, six strains of L. monocytogenes were investigated. The molecular changes in the expression of pfLA and ftsL genes in L. monocytogenes, both before and after exposure to CNPs, were analyzed using a real-time polymerase chain reaction (RT-PCR) assay. Results: The study found that the expression of pfLA and ftsL genes in L. monocytogenes altered following exposure to CNPs. Specifically, the pfLA gene expression increased, while the ftsL gene expression decreased in all strains of L. monocytogenes. Conclusions: Based on the present results, CNPs appear to be effective in preventing infections and complications associated with listeriosis.
Factor Structure of Parental Reflective Functioning Questionnaire for Mothers Working at Qazvin University of Medical Sciences
Authors: Bahramkhani Mahmoud , Mohammad Hoseini Sara , Sarichloo Mohammad Ebrahim
Published: February 2024

Background: Maternal reflective functioning refers to a mother's ability to understand the mental states of herself and her child. This capacity is related to the attachment styles of the mother and child, as well as the mentalizing capacity of the child and his/her behavioral problems. The Parental Reflective Functioning Questionnaire (PRFQ) was developed to evaluate the capacity of mothers. Objectives: This study aimed to determine the factor structure, structural validity, and psychometric properties of PRFQ in mothers working at Qazvin University of Medical Sciences. Methods: The study was a methodological one conducted by structural equation modeling to investigate the factor structure of PRFQ designed by Luyten et al. in 2017. Two samples, including 183 and 120 mothers working at Qazvin University of Medical Sciences in 2021, were selected using convenience sampling for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), respectively. For data collection, the participants completed PRFQ, Adult Attachment Inventory (AAI), Symptom Checklist-25 (SCL-25), RFQ, and Emotional Availability Self-Report (EA-SR). For data analysis, statistical methods, including EFA, CFA, and correlation analysis, were used in SPSS and AMOS software packages. Results: The Cronbach’s alpha for the total questionnaire was equal to 0.6. The exploratory factor analysis showed that PRFQ had a 3-factor structure with a shared variance of 38.03%. Item 11 loaded on all factors, and items 6 and 18 loaded on the pre-mentalization factor. The developed model was approved by removing item 11 and loading items 6 and 18 on the pre-mentalization factor in CFA (comparative fit index [CFI] = 0.93, normed fit index [NFI] = 0.82, Tucker-Lewis index [TLI] = 0.92, and root mean square error of approximation [RMSEA] = 0.05). The results also revealed that the developed questionnaire had adequate concurrent and predictive validity. Conclusions: Overall, the 3-factor structure of PRFQ for mothers showed adequate validity and reliability.
High-dose Versus Low-dose Oral Ketamine on Control and Relapse of Treatment-resistant Depression: A Randomized, Double-blinded Clinical Trial
Authors: KheirAbadi Gholamreza , Golkar Shirin
Published: February 2024

Background: Treatment-resistant Depression (TRD) does not respond to conventional treatments. Despite the efforts made to control depression, the outcomes are controversial and inconclusive. New strategies such as ketamine use are accompanied by promising outcomes; however, the best dosage remains a question. Objectives: The current study aimed to compare the effect of 1 and 2 mg/kg of oral ketamine in TRD subjects. Methods: The current randomized clinical trial was conducted on 29 patients suffering from TRD. The patients were randomly assigned into two groups of treatment with low dose (1 mg/kg; n = 17) versus high dose (2 mg/kg; n = 12) oral ketamine twice a week for six weeks. The Hamilton Depression Rating Scale (HDRS) and the Beck Depression Inventory-II (BDI-II) were applied to assess the outcomes of the interventions at baseline, within 2, 4, and 6 weeks after the interventions, and then, within a week, a month, and 2 months after the end of the intervention. Results: Baseline HRDS (P-value = 0.393) and BDI-II (P-value = 0.0.919) were similar in both groups. Neither HDRS (P-value = 0.97) nor BDI-II (P-value = 0.71) had a significant trend of changes when low versus high-dose ketamine uses were compared. The comparison of the frequency of ketamine-related adverse effects revealed a significantly higher incidence of drowsiness (P-value = 0.021) and lightheadedness (P-value = 0.004) in high-dose ketamine. Conclusions: We achieved no conclusive superiority or efficacy of 1 mg/kg over 2 mg/kg of oral ketamine; however, considering the adverse effects, a 1 mg/kg dose is preferred.
Naringin Reduced the Density and Total Number of Aβ Plaques and Restored Memory Function and Volume of Hippocampal CA1 Area in Alzheimer's Disease Model Rats: A Stereological Study
Authors: Yazdani Fateme , Jahanshahi Mehrdad , Elyasi Leila , Badeli Sarkala Hamzeh
Published: February 2024

Background: Alzheimer's disease (AD), the most prevalent form of dementia worldwide, is characterized by memory impairment and the accumulation of tau and beta-amyloid (Aβ) plaques. Naringin, a flavonoid, has exhibited strong anti-inflammatory, anti-oxidant, and anti-apoptotic properties. Objectives: In this study, we aimed to demonstrate the neuroprotective effects of naringin on memory function, the total number and density of Aβ plaques, and the volume of the hippocampal CA1 region in a scopolamine (SCO)-induced AD model in rats. Methods: Forty male Wistar rats were randomly divided into the following groups: A control group, a saline + SCO (3 mg/kg) group (pretreated with 200 µL saline), and 3 treatment groups receiving naringin at doses of 50 mg/kg/day + SCO, 100 mg/kg/day + SCO, and 200 mg/kg/day + SCO (pretreated with 50, 100, or 200 mg/kg of naringin) for 14 consecutive days via intraperitoneal (IP) injection. After the 14-day pretreatment period, the saline + SCO and 3 naringin treatment groups received SCO (3 mg/kg) to induce an AD-like condition. Memory function was assessed using the inhibitory passive avoidance test. Following brain harvesting, paraffin-embedded coronal brain slices were stained with Congo red, and the density and the total number of Aβ plaques and the volume of the hippocampal CA1 area were estimated using unbiased stereological techniques. Results: The results indicated that naringin significantly improved memory function, with the most pronounced effect observed in the naringin 200 mg/kg + SCO group. Stereological analysis revealed that SCO reduced the volume of the hippocampal CA1 area and increased the total number and density of Aβ plaques. Pretreatment with naringin significantly restored the hippocampal CA1 volume in the 200 mg/kg + SCO group compared to the saline + SCO group. Additionally, naringin reduced the total number and density of Aβ plaques, with the most significant decrease observed in the 200 mg/kg + SCO group. Conclusions: Naringin restored memory function and the volume of the hippocampal CA1 region while reducing the total number and density of Aβ plaques in a SCO-induced AD model in rats. This stereological study complements previous molecular research on naringin's neuroprotective effects in AD-like pathogenesis.
Comparing the Effect of Internet-Delivered Interpersonal Psychotherapy and Compassion-Focused Therapy on the Quality of Life and Grief Experience of First-Degree Relatives of the Deceased Due to COVID-19
Authors: Malekmohammadi Maryam , Zargar Fateme , Moayedi Zahra , Salehi Mehrdad , Tarrahi Mohammad Javad , Salimi Hajar
Published: February 2024

Background: The COVID-19 pandemic presents an extreme threat to global health and stands as one of the leading causes of death worldwide. Loss, as a broader theme, intertwines with various aspects of people’s lives during these challenging times. Failing to address the urgent needs of individuals experiencing loss and grief can result in poor mental and physical health. Objectives: Our study aimed to evaluate the impact of interpersonal psychotherapy (IPT) and compassion-focused therapy (CFT) on the grief and quality of life (QoL) of first-degree relatives who lost loved ones due to the COVID-19 pandemic. Methods: This study was a randomized clinical trial. Participants who had lost a family member to COVID-19 between March 2019 and September 2020 and who visited the hospitals affiliated with Isfahan University of Medical Sciences were selected based on specific inclusion and exclusion criteria. Forty participants were randomly assigned to either IPT or CFT, and each group underwent 6 weekly sessions. The Grief Experience Questionnaires and the World Health Organization’s Quality of Life Questionnaires were administered to all individuals via phone interviews before commencing treatment and 1 month after completing the sessions. Results: The results indicated a significant improvement in both treatment groups individually (P < 0.001). However, when comparing the 2 groups while adjusting for the pre-test effects, there were no significant differences between them in any of the following areas: Physical response (P2 = 0.45), notoriety (P2 = 0.53), justification and coping (P2 = 0.59), guilt (P2 = 0.31), feelings of abandonment (P2 = 0.52), judgment by others (P2 = 0.78), and embarrassment and shame (P2 = 0.79). Conclusions: The findings from our study demonstrate that both IPT and CFT resulted in improved QoL and reduced grief experiences. Therefore, these therapeutic approaches can be employed to alleviate grief symptoms and enhance overall QoL.
The Inverted U-shaped Curvilinear Relationship Between Conscientiousness and the Quality of Life in Patients with Irritable Bowel Syndrome
Authors: Hamidian Kaveh , Meschi Farahnaz , Taghdisi Mohammad Hossein , Manouchehri Mehdi
Published: February 2024

Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that greatly affects the quality of life. While prior research suggested a linear connection between conscientiousness and health outcomes like quality of life, recent studies propose a more intricate, curved relationship. Objectives: The present study aimed to determine the inverted U-shaped curvilinear relationship between conscientiousness and quality of life in patients with irritable bowel syndrome. Methods: This descriptive-correlational study in Tehran's private gastroenterology clinic in 2020 included 232 IBS patients. Data collected via the NEO Five-Factor Inventory (NEO-FFI) and Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire were analyzed using SPSS version 26 and Excel 2023 for statistical assessment at a 95% confidence interval. Results: Scatter plots and regression equations demonstrated a strong curvilinear relationship (R2 = 0.14) between conscientiousness and IBS patients' quality of life, surpassing the linear relationship (R2 = 0.08). Curvilinear regression analysis revealed significant correlations (95% CI) for both the first-degree coefficient (β1 = 2.304, P < 0.001) and the second-degree coefficient (β2 = -2.043, P < 0.001). Conclusions: The findings indicate an inverted U-shaped relationship between conscientiousness and quality of life in IBS individuals. This underscores the importance of addressing exceptionally high conscientiousness levels in healthcare.
Effect of Music and Lemon Aroma on Anaerobic Power and Balance of Athletes After Exhausting Activity
Authors: Adanur Oğuzhan , Oncu Mertkan , Turkmen Musa , Eken Özgür , Kurtoğlu Ahmet , Yermakhanov Baglan , Setiawan Edi , Muracki Jaroslaw
Published: February 2024

Background: The aim of this study was to investigate the effect of lemon aroma (LA) and music on anaerobic power and balance in athletes following sporting activity. Recognizing the potential influence of sensory stimuli on performance, we sought to contribute valuable insights into optimizing recovery strategies for athletes. Objectives: The primary objective was to assess the effects of LA and music on anaerobic power and balance, employing a comprehensive set of physical fitness factors. Methods: Twelve male amateur athletes were randomly included in our study. These individuals were given LA, music, and with no supplementation (control) for 72 hours, followed by a standardized recovery phase using a Monarch ergometer, and lactic acid levels were measured after the intervention to assess the physiological effect. Balance analysis covering both static and dynamic conditions was performed using a specialized balance machine. Isometric dynamometer measurements and detailed assessments of Sargent's jumping performance were performed to analyze physical fitness factors. Results: Significant differences were observed in balance parameters, with both static balance (SB) and dynamic balance (DB) registering higher values in the control time (P = 0.006; P < 0.001, respectively). Lemon aroma exposure resulted in the highest values for peak power (PP) and relative PP (RPP) (P < 0.001; P < 0.001, respectively). Conversely, in the control time exhibited the lowest values for relative anaerobic power (RAP) and vertical jump (VJ). Conclusions: The findings suggest a positive influence of stimulating aroma (lemon) and music elements on sportive performance. Lemon aroma was associated with enhanced anaerobic power, while the control group exhibited superior balance outcomes. These results underscore the potential benefits of incorporating sensory interventions into athletes' recovery protocols for optimized performance.
The Impact of Resistance Training on IL-6, TNF-a, and CRP Levels in the Elderly: A Systematic Review and Meta-Analysis Study
Authors: Rahimi Mohammad Rahman , Mehrwand Zanyar
Published: February 2024

: Background: Inflammatory markers have been linked to an increased risk of cardiovascular diseases including atherosclerosis, coronary artery disease, and heart failure in the elderly individuals. Resistance exercises are one effective method to manage inflammation in this population. Objectives: This meta-analysis aimed to explore the impact of resistance training on inflammatory markers in the elderly. Methods: All randomized controlled clinical trials (from 2004 to 2023) that examined the effect of resistance training on tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and C-reactive protein (CRP) in individuals over 50 years old were selected through a systematic search of PubMed, Google Scholar, Web of Science and SID databases, that out of 600 studies identified, 31 met the inclusion criteria for our analysis. Random and fixed effects models, along with the I2 heterogeneity test, Egger test, and funnel plot, were used to determine publication bias using CMA2 software. The effect size (ES) was reported in terms of the standard mean difference (SMD) and a 95% confidence interval (CI). Results: The meta-analysis results indicated that resistance training significantly reduced CRP (ES = -0.49, 95% CI = -0.34 to -0.64, P = 0.001) and IL-6 (ES = -0.27, 95% CI = -0.41 to -0.13, P = 0.001) levels. However, it did not have a significant effect on TNF-α levels (ES = -0.22, 95% CI = 0.02 to -0.47, P = 0.075). Subgroup analyses revealed that resistance training for more than 16 weeks and a training frequency of three times a week led to a greater decrease in CRP and IL-6 levels in the elderly. Conclusions: The findings of this meta-analysis suggest a significant decrease in CRP and IL-6 levels in the elderly due to resistance training. Furthermore, the subgroup analysis indicated that higher training volumes (training duration and frequency) result in a greater reduction in these markers' levels. Based on these findings, it is advisable for elderly individuals to consider incorporating resistance training into their regular exercise routines.
Exploring the Impact of Treating Functional Constipation on Headache Episodes in Children Suffering from Migraine
Authors: Fayyazi Afshin , Shirmohamadi Maryam , Soltanian Ali Reza , Bazmamoun Hassan
Published: February 2024

Background: Migraine and functional constipation are prevalent chronic conditions among children, with many children suffering from migraines also experiencing functional constipation. Objectives: This study aims to investigate the impact of constipation treatment on headaches in children with migraines. Methods: This clinical trial involved 32 children aged 4 to 15 years, all diagnosed with both migraine and functional constipation. They were randomly divided into two groups: An intervention group and a control group, each comprising an equal number of participants. In the intervention group, both migraine and constipation were treated concurrently, whereas in the control group, only migraine was addressed. The outcomes of the two groups were then monitored and compared. Results: After the treatment, the intervention group experienced a significant reduction in the average number of monthly headache attacks (3 ± 2.4) compared to the control group (7.1 ± 6.9) with a P-value of 0.016. The average duration of each headache attack was shorter in the intervention group (2.3 ± 4.8 hours) compared to the control group (2.9 ± 4.2 hours), although this difference was not statistically significant. Parental satisfaction with the treatment was higher in the intervention group than in the control group, but this difference also lacked statistical significance. Constipation treatment was successful in all children in the study. Conclusions: The study's findings indicate that treating constipation in children with both migraine and functional constipation significantly reduces the frequency of headache attacks. However, it does not have a significant impact on the duration of headache attacks or on parental satisfaction with the treatment.
Molecular Detection and Identification of oprl and lasb Genes Isolated from Pseudomonas aeruginosa
Authors: Ghazaei Ciamak
Published: February 2024

: Species Pseudomonas aeruginosa is a distinguished opportunistic nosocomial bacterium that is commonly dispersed in nature. A pathogen that causes a large range of infections i.e. chronic as well as acute, with considerable levels of mortality and morbidity. Infections of P. aeruginosa are extremely hard to eliminate because of the presence of several virulence determinants as well as the intrinsic resistance against antibiotics. The present study investigated the detection of the virulence genes by polymerase chain reaction (PCR) namely oprL and lasB in the P. aeruginosa that were isolated detection from both human and animal specimens. 120 specimens of P. aeruginosa including samples were then collected from hospitals and veterinary laboratories, from which 55 isolates of P. aeruginosa were identified and selected. Pseudomonas aeruginosa strains were present in 40% of animal sample isolates and 86% of human sample isolates. The PCR results showed that oprL genes were detected in 54.16% of isolates obtained from animal samples and 80.76% of isolates obtained from human samples. While, the lasB gene was present at 58.33% and 92.30% in the isolates obtained from animal and human samples, respectively. Our results also showed the coexistence of both virulence genes in 32.34% of animal sample isolates and 25.10% of human sample isolations. The detection of gene oprL and lasB by the PCR technique can be effectively used for the molecular-level identification of P. aeruginosa. The identification of such virulence genes in P. aeruginosa isolates suggests that these may be linked with varying degrees of the pathogenesis and inherent virulence in this pathogen.
The Effect of Preoperative Education on Preoperative Anxiety in Patients Waiting for Surgery: A literature Review
Authors: Samadi Shahram
Published: February 2024

Context: Among patients undergoing surgery, preoperative anxiety (PA) is one of the most common psychological problems that can negatively impact the patient's physical health and the operation's outcome. Preoperative patient education (PPE) is a way to reduce PA, which has many advantages over pharmaceutical methods. Therefore, this study aimed to evaluate the effectiveness of PPE on PA in patients who are candidates for surgery by reviewing similar previous studies. Evidence Acquisition: The data in this narrative review were collected by searching past studies in reliable international databases, including Web of Science, Science Direct, Scopus, PubMed, and Google Scholar, in the last two decades. In the first stage of the search, 248 articles and scientific reports were received, and then 30 articles were selected as final studies by considering the inclusion and exclusion criteria. Results: In most previous similar studies, PPE significantly reduced PA in patients who are candidates for surgery. However, the findings of a small number of studies also showed that PPE had little positive effect, no effect, or negative effect on PA control. There were different methods to provide information to patients before surgery, and the efficiency and application of each were different based on the demographic characteristics of the patients. Conclusions: Based on the findings, appropriate training methods can reduce the level of PA in patients who are candidates for surgery. However, in some past studies, providing information about the surgical procedure may increase patients' PA. Therefore, nurses or medical staff with more contact with patients are suggested to have sufficient experience and knowledge in providing information and choosing the training method for patients before surgery.
Applying a Meta-synthesis Approach to Present a Blended Learning Model for Talent Development
Authors: Mirchi Sanaz , Vedadi Ahmad , Gholamzadeh Dariush
Published: February 2024

Background: With the rapid development of healthcare, traditional teaching has been unable to meet the learning needs of hospital staff training, which has led to talent development. With the development of Internet technology, blended learning seems to be a new available choice to solve the current predicament. However, the effectiveness of blended learning is still controversial. In addition, most studies have primarily evaluated the teaching effect unilaterally. Objectives: The purpose of this study was to apply a meta-synthesis approach to synthesize research on blended learning models for talent development in healthcare settings. By examining a body of evidence from peer-reviewed studies, the authors aimed to identify common elements of effective blended learning models applied to hospital employee training. This synthesis provided a foundation for developing a comprehensive blended learning model tailored to the specific needs of hospital employees. Methods: In this study, the meta-synthesis approach was used to synthesize qualitative evidence in relation to blended learning factors in talent development. A comprehensive search strategy was used to retrieve articles from ScienceDirect, Emerald, PubMed, Web of Science, and Scopus within 1990 to 2023. To find additional studies, the bibliographic search of included studies and review articles and a random search in Google Scholar, Research Gate, and Google were carried out. A total of 751 studies were identified. After reviewing the full text of the articles, 89 studies were selected. This review evaluated studies that explained blended learning and talent development among healthcare employees. Eighty-six studies were selected and included in the meta-synthesis process after critical appraisal using the Critical Appraisal Skills Program. Results: The findings consisted of the model’s dimensions, components, and indices. The five identified dimensions include specifying learning needs, learning campaign elements, learning proposal, content strategy, and facilitation model consisting of 22 components and 76 indices. Conclusions: The identification and application of the obtained components will allow the policymakers and managers of the health system field to replace the traditional training of employees with blended learning, culminating in employee talent development.
Sosialisasi Bahaya Mengonsumsi Ikan Tercemar Di Desa Jirak Kecamatan Sajad
Authors: Widia Widia , Agam Beryaldi , Fikri Muhammad Zakiyul , Sangkala Sangkala , Sigiro Oktavia Nurmawaty , Yunita Nurul Fatimah , Asrul Asrul , Nugroho Bayu , Agusriani Deya , Aldina Jian Rifa , Joni Joni , Ludiyansyah Ludiyansyah , Masnita Masnita , Nurkholis Muhammad Faris , Marjulita Marjulita , Neny Neny , Ahyana Ridho
Published: February 2024

Water has a crucial role in human life and ecosystems, especially as a source of life. However, the sustainability of water sources, such as rivers, is threatened by industrial waste pollution, as happened to the Jirak River in Sambas City. This condition is caused by the poor system of Wastewater Sewerage (SPAL) and Wastewater Management Plant (WWTP), as well as the shortage of latrines around the river. In 2014, the Ministry of Environment of the Republic of Indonesia noted that 75% of rivers in Indonesia experienced heavy pollution, including the Jirak River. One of the main pollutants is mercury (Hg), which can be toxic and harmful to human health. Therefore, it is necessary to make prevention and counseling efforts to the community. The purpose of this counseling is to socialize about the dangers of consuming polluted fish in Jirak Village in the Jirak River area of Sambas Regency, and also provide awareness to the surrounding community to consume fresh fish that can be applied in people's lives in a sustainable manner. The location of this counseling is the Jirak River located in Sambas Regency, West Kalimantan Province. The approach used in this community service activity is to provide socialization and direct communication to mothers in Jirak Village. The socialization participants participated in the activity by actively discussing and experiencing increased knowledge and understanding of the dangers of consuming polluted fish.
The Impact of Changes in the Independent Curriculum on Learning in Schools
Authors: Abdul Fattah Nasution  , Hasita Dwi Putri  , Nurtika Syahputri  , Laila Parhani Hasibuan  , Azaman Andra
Published: February 2024

The curriculum merdeka has become an increasingly popular approach in recent years, providing greater freedom for schools, teachers, and students to develop and organize their own curriculum. However, these changes also present various challenges and issues in their implementation. This article employs a literature review method to gain a deep understanding of the impact of these changes. The analysis reveals that the curriculum merdeka changes can pose challenges in curriculum development and organization for teachers and schools. There is also a potential gap between schools in implementing the curriculum merdeka. Additionally, the readiness and adequate support for teachers are crucial factors in the success of the curriculum merdeka. To address these challenges, this research emphasizes the importance of adequate training and regular monitoring to improve the quality of learning in schools. By understanding the impact and challenges related to the curriculum merdeka changes, this article aims to provide valuable insights for educational practitioners and policymakers in enhancing the quality of education.
The Principal's Efforts in Building Brand Image and Competitiveness in MI Al Qodir Wage Taman Sidoarjo
Authors: Lutfi Firdausi  , Prim Masrokan  , Agus Eko Sujianto
Published: February 2024

Establishing Islamic Education Institutions in this era of globalization is an opportunity to face the challenges of the times. Maintaining it is even more difficult to compete with other institutions. Challenges and competition come from internal and external institutions. Challenges and competition come from internal and external institutions. Building a good perspective for (Brand image) users of institutions is one of the inevitability in building and introducing transformative Islamic educational institutions to the community in order to increase the competitiveness of Islamic Education Institutions. Through descriptive qualitative research supported by data from the field at MI al Qodir Wage Taman Sidoarjo, it was obtained that efforts to build a brand image of transformative Islamic educational institutions can be done through; 1) Market Identification 2) Segmentation and Positioning, 3) Differentiation of Education Services, and 4) Services of Transformative Islamic Education Institutions. Meanwhile, to build a brand image, this Islamic educational institution implements the theory of the marketing mix known as the 7P formula, namely; Product, Price, Place, Promotion, People, Physichal Evendnce, and Process.  Furthermore, to maximize the positive impact of brnad image, institutions need to pay attention to supporting factors, including; a) Product Attributes or values that accompany the product, and b) Consumer Benefits of excellence or benefits obtained by consumers.
Grounds and First Principles in Heidegger and Hegel
Authors: Munroe Samuel Patrick ,   Philosophy Documentation Center
Published: February 2024

In this article, I provide an interpretation of Heidegger’s critique of Hegel. Hegel’s ability to provide a presuppositionless metaphysics is often taken to be the core strength of his Logic. In his critique of Hegel, Heidegger attempts to show that Hegel in fact smuggles in a decisive presupposition concerning being. Building on the recent work of Robert Pippin, I argue that we can understand this critique by situating it in terms of their common understanding of problems of first principles. Once we do, we can fully appreciate a point that Pippin misses, that Heidegger develops his methodology and concept of ground in order to avoid the problems that he locates in Hegel. The upshots of my interpretation are that it (1) allows us to appreciate the systematicity and radicality of Heidegger’s mature ontology, and (2) forces those sympathetic to Hegel to reevaluate Hegel’s ability to provide a presuppositionless metaphysics.
Основні форми та види ефективної діяльності підприємства малого бізнесу
Authors:   Вінницький інститут Університету «Україна», Балахонова Олеся , Вокалюк Богдан ,   Вінницький інститут Університету "Україна"
Published: February 2024

У статті досліджено забезпечення ефективної та продуктивної господарської діяльності підприємства малого бізнесу. Ефективна діяльність підприємства малого бізнесу є якісною характеристикою його загального фінансового стану. Відображає тенденції зміни економічно-фінансових відносин на підприємстві під впливом факторів внутрішнього і зовнішнього середовища. Визначає фінансову незалежність від зовнішніх джерел фінансування та оптимальну структуру активів і джерел їх покриття. Ефективність діяльності підприємства малого бізнесу досягається в процесі стратегічного та оперативного управління такими складовими економічного стану як: інноваційна активність, організаційна гнучкість, конкурентоспроможність, здатність до диверсифікації, новітні технології. Виділено три основні форми ефективної діяльності підприємства малого бізнесу: рівноважна (початкова форма), зростання без розвитку, ефективна (вища форма діяльності).
Вдосконалення методів оцінки продуктивності та ефективності праці в торговельних підприємствах
Authors:   Вінницький соціально-економічний інститут Університету «Україна», Турчак Вікторія , Рибак Володимир ,   Вінницький соціально-економічний інститут Університету «Україна»
Published: February 2024

У статті проводиться аналіз ефективності праці в умовах переходу України до ринкової економіки, акцентуючи на важливості переосмислення економічної природи праці та її комплексного впливу на розвиток суспільства. Ефективність праці розглядається як широка соціально-економічна категорія, що охоплює живу, уречевлену та майбутню працю, підкреслюючи їх роль у збільшенні вільного часу, зниженні виробничих витрат та задоволенні потреб людей. Особлива увага приділяється потребі розробки нових підходів до оцінки та стимулювання ефективності праці, зокрема через врахування її привабливості та впливу на якість товарів та послуг. Стаття закликає до створення комплексної системи показників для аналізу та підвищення ефективності праці, що є ключовим для економічного зростання та соціального розвитку.
Сучасні теоретичні підходи до класифікації форм та видів корпоративного контролю
Authors:   Вінницький фаховий коледж НУХТ, Чеснік Наталія , Побережник Павло ,   Миколаївський міжрегіональний інститут розвитку людини Університету «Україна»
Published: February 2024

У даній статті розглядаються ключові аспекти корпоративного контролю, включаючи його визначення, форми, види, а також характеристики завдань, суб'єктів та об'єктів. Зокрема, висвітлено різноманітні форми корпоративного контролю та види, які застосовуються в сучасних умовах управління корпоративними структурами. У статті також розглянуті завдання, які ставляться перед суб'єктами корпоративного контролю, а також об'єкти, які піддаються контролю. Детально розкрито принципи, які лежать в основі корпоративного контролю, і як вони сприяють оптимізації управлінських процесів та забезпеченню стійкого функціонування корпорацій.
Використання штучного інтелекту в управлінні діяльністю підприємства
Authors:   Вінницький соціально-економічний інститут Університету «Україна», Швед Вадим , Щур Ігор ,   Вінницький соціально-економічний інститут Університету «Україна»
Published: February 2024

Стаття висвітлює актуальність інтеграції штучного інтелекту у сферу управління діяльністю підприємств, а також зосереджує увагу на потенціалі та викликах, пов'язаних з цим процесом. Автори розкривають значення штучного інтелекту для оптимізації виробничих процесів, підкреслюючи його спроможність ефективно обробляти великі обсяги даних та автоматизувати рутинні завдання, що сприяє звільненню ресурсів для стратегічних цілей. Також акцентується на аналітичних засобах, які штучний інтелект надає для прийняття обґрунтованих управлінських рішень. Стаття надає конкретні приклади використання ШІ в різних галузях та компаніях, підкреслюючи його значення для підвищення продуктивності, зниження витрат та стимулювання інновацій.