bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery of zerumbone as a new agent for cardiac hypertrophy by high-throughput screening using human embryonic stem cell-derived cardiomyocytes
Authors: Huang Jie , Chen Haiyan , Lan Shujue , Qin Le , Xun Zixuan , Han Shuai , Zhao Hongwei , Ci Yunqing , Xu Chen , Zhu Wenjia , Lu Xinya , Chen Jiaxin , zheng Qiuyi , Li Ermin , Chen Xinyun , Lu Chao , Qian Ruizhe , Chen Sifeng , Li Xiaobo , Sun Ning
Published: April 2022

Background: Pathological cardiac hypertrophy is considered an adaptive response of the heart due to cardiovascular diseases such as hypertension, aortic and valvular stenosis, and inherited cardiomyopathy caused by mutations in sarcomeric proteins. It is a risk factor of various forms of cardiovascular diseases and closely associated with heart failure. Current medications for cardiac hypertrophy are limited and often only target the symptoms without a radical effect. There is a strong demand for developing new drugs to improve the overall treatment. Methods: We firstly established a hypertrophy model of human embryonic stem cell (hESC)-derived cardiomyocytes by norepinephrine treatment. Using high-throughput drug screening a library of small-molecule natural products and high-content analyses of hESC-cardiomyocyte size, we identified zerumbone as an effective new agent alleviating concentric cardiac hypertrophy. The downstream molecular pathway induced by zerumbone was identified by RNA-seq analyses of zerumbone treated hESC-cardiomyocytes and confirmed by biochemical studies.Results: We found that zerumbone not only inhibited norepinephrine-induced hypertrophy of hESC-derived human cardiomyocytes in vitro, but also alleviated cardiac hypertrophy in spontaneous hypertensive rats and Mybpc3-G790A hypertrophic cardiomyopathy mice in vivo. This inhibition of cardiac hypertrophy by zerumbone was not dependent on lowering blood pressure. We further found that zerumbone markedly activated the NRF2/HO-1 related signaling pathway which showed a cardioprotective effect on cardiac hypertrophy. Zerumbone directly bound to and induced high molecular weight KEAP1, which impeded the interaction of CUL3 with KEAP1, leading to the inhibition of NRF2 ubiquitination and NRF2 accumulation and translocation into the nucleus. Inhibition of HO-1 expression blocked the effect of zerumbone in attenuating cardiomyocyte hypertrophy. Conclusion: Our data indicate that zerumbone is an effective small molecule alleviating pathological cardiac hypertrophy. It could be used in combination with current antihypertensive drugs for hypertension patients with cardiac hypertrophy and may also be used for patients of inherited hypertrophic cardiomyopathy.
DETERMINATION OF OPTIMAL PARAMETERS FOR CALCULATING TERRAIN CORRECTIONS BASED ON DIGITAL TERRAIN MODELS (ON THE EXAMPLE OF EASTERN TRANSBAIKALIA)
Authors:   Transbaikal State University, Chita, Gruzdev, R , Rylsky I. ,   Lomonosov Moscow State University, Moscow
Published: April 2022

The study of corrections for the influence of terrain is a very popular and significant procedure in the production of high-precision gravimetric work. The results of such studies allow us to determine the optimal parameters for calculating terrain corrections, which helps to reduce the error in calculating the anomaly of the force of gravity in the Buge reduction and, accordingly, leads to an increase in the quality of the interpreted material. Therefore, the improvement of the methodology for calculating corrections for terrain is of particular interest for gravity exploration today and is a very relevant direction in high-precision surveying. Thus, in this article, the purpose of the study is to determine the optimal parameters for calculating terrain corrections for during high-precision gravimetric surveying. The degree of elaboration of the study indicates a number of unresolved issues, which are to some extent disclosed by the authors as a result of calculations and analysis of digital grids, graphs and other data involved in calculating terraincorrections. The article discusses the actual materials and methods for determining corrections for the influence of terrain, obtained during the production of high-precision field gravimetric work on one of the objects of the Trans-baikal Territory. In the course of the study, the results of determining the terraincorrections are presented, comparisons of the corrections in different zones are made, their quantitative indicators are analyzed, and statistics are provided. With the help of mathematical modeling, matrices (grids) of calculated parameters are constructed. The results of the study are clearly demonstrated in the diagrams and in the final tables, which indicates the reliability of the study performed. On the basis of the conducted research, conclusions are drawn and recommendations are made for the method of calculating corrections for the influence of terrain
DEVELOPMENT OF RESORT INFRASTRUCTURE BASED ON BALNEOLOGICAL RESOURCES
Authors:   Perm Institute (branch) of the Russian Economic University named after G. V. Plekhanov, Perm, Oborin M.
Published: April 2022

The article is devoted to the study of the directions of infrastructural development of territories with resort specialization on the basis of balneological resources, the use of which can be promising not only in the conditions of the sanatorium-resort complex, but also related types of economic activity. The Perm Region has a significant balneological potential, a program approach to the development of which can become the basis for the investment development of resort medicine and individual resorts. The object of the study is the directions of commercial use of the balneological resources of the region. The purpose of the study is to determine the most popular types of economic activity using the balneological potential of the Perm Region. The objectives of the study include the assessment and justification of some business areas related to the development of resort medicine. Research methods: system and situational approaches, marketing analysis. In the course of the study, it was determined that the potential of the territories of the region can be used more effectively, as it is represented by unique therapeutic waters that can be used in various areas of services related to treatment, rehabilitation and rehabilitation. The state of the resources of the Perm Region from an economic point of view is characterized by an insufficient degree of involvement in the activities of the sanatorium-resort complex, the sector of paid medical and wellness services, which is based on cosmetic procedures, healthy nutrition. The systematic formation of a supply designed for various market segments will contribute to sustainable demand in the region and higher rates of recovery of financial and economic indicators of health resorts in the region
Dynamic modeling and analysis of elastic isolation damping gears
Authors: Jiang Hanjun , Liu Fuhao
Published: April 2022

Transmission error is the main excitation source of gear vibration and noise, how to reduce the transmission error has always been the focus of the research on gear dynamics. In this study, a new type of cylindrical spur gear with elastic isolation is developed for the reduction of transmission error. The elastic isolation damping gear includes three parts: the gear body, the elastic isolation layer, and the involute profile body. Dynamic models are established with the elastic isolation damping gear using lumped parameter method. Dynamic characteristics are simulated via spur gear pair examples by the Runge-Kutta algorithm. By comparing the simulation results of three gear models, the dynamic response of the elastic isolation damping gear with sliding friction is illustrated. The influence of different parameters of the elastic isolation layer on the dynamic response for the elastic isolation damping gear model is carried out. The results indicate that the proposed elastic isolation damping gear model is effective in reducing dynamic transmission error, especially for torque fluctuation, high-speed and heavy-duty conditions. Parameter influence analysis guides the design of elastic isolation damping gears with low transmission error.
Rapid Analysis of Risk of Sustainable Agriculture Development: Socio-Ecological-Economic Approach
Authors: Sergienko Oksana
Published: April 2022

The article proposes a methodology for rapid analysis of risks of sustainable agricultural development based on statistical data from the perspective of the socio-ecological-economic approach of the agricultural sector. Methods: synthesis, statistical analysis, and comparison methods. The practice of world and domestic experience of using methods of assessment of sustainable development using development indicators is described. The author presents an analysis of the main economic indicators of agricultural production of the Omsk region, the financial results of economic activities of agricultural producers taking into account three components – economic, social, environmental. An assessment of the resilience of indicators from the point of view of signs of sustainable and unstable development of the agricultural industry is given. The article considers threats to the sustainable safe development of agriculture in the region, considering the monitoring of the economic component and the positive trend of the most growing sector of the economy. The main aspects of sustainable development of the agricultural sector of the region were considered, the relationship between the socio-ecological and economic components of sustainable development of agricultural production from the point of view of assessing the risks of sustainable development was revealed. An interpretation of the author's express analysis of the main components of the development of the agricultural sector in the Omsk region with the identification of risk zones and the threat of unstable development of the industry is presented.
Development of a qPCR assay for the detection of naturalized wastewater E. coli strains
Authors: Zhi Shuai , Banting Graham , Neumann Norman F.
Published: April 2022

We recently demonstrated the presence of naturalized populations of Escherichia coli in municipal sewage. We wanted to develop a quantitative polymerase chain reaction (qPCR) assay targeting the uspC-IS30-flhDC marker of naturalized wastewater E. coli and assess the prevalence of these naturalized strains in wastewater. The limit of detection for the qPCR assay was 3.0 × 10−8 ng of plasmid DNA template with 100% specificity. This strain was detected throughout the wastewater treatment process, including treated effluents. We evaluated the potential of this marker for detecting municipal sewage/wastewater contamination in water by comparing it to other human and animal markers of fecal pollution. Strong correlations were observed between the uspC-IS30-flhDC marker and the human fecal markers Bacteroides HF183 and HumM2, but not animal fecal markers, in surface and stormwater samples. The uspC-IS30-flhDC marker appears to be a potential E. coli-based marker for human wastewater contamination.
Experimental study of the growth period of wall-attached bubbles
Authors: Lin Lu , Li Ran , Feng Jingjie , Cheng Xiaolong , Yuan Youquan , Wang Zhenhua
Published: April 2022

Due to dam discharge, waterfalls, sudden increases in water temperature and oxygen production by photosynthesis, the total dissolved gas (TDG) in water is often supersaturated, which may have serious effects on aquatic ecology. Wall-attached bubbles formed during the TDG release process and the generation and departure of wall-attached bubbles influenced the release of TDG from water. Therefore, an experiment was performed to simulate the growth of wall-attached bubbles at various water flow velocities, a quantitative relationship between the wall-attached bubble growth period and flow velocity was obtained. Another quantitative relationship, between the wall-attached bubble departure diameter and turbulent kinetic energy of flowing water, was also determined. The analysis results of the TDG release rate proved that the adsorption of TDG on solid walls was considerably affected by flow velocity. The analysis models the TDG release mechanism through complex experiments and provides a method to better identify sites for supersaturated TDG adsorption. This study serves as an important theoretical basis for revealing the mechanism by which solid surfaces promote the release process of supersaturated TDG in natural water.
Hybrid CNN-LSTM models for river flow prediction
Authors: Li Xia , Xu Wei , Ren Minglei , Jiang Yanan , Fu Guangtao
Published: April 2022

River flow prediction is a challenging problem due to highly nonlinear hydrological processes and high spatio-temporal variability. Here we present a hybrid network of convolutional neural network (CNN) and long short-term memory (LSTM) network for river flow prediction. The hybridization enables accurate identification of the spatial and temporal features in precipitation. A shortcut layer is used as an additional channel of passing input features through the deep network to increase feature diversity. The flows in Hun River Basin, China are predicted using the trained hybrid network and are compared with the results from the Soil and Water Assessment Tool (SWAT) model. The results demonstrate the learning efficiency of the hybrid network is greatly affected by its structure and parameters, including the number of convolutional layers and LSTM cell layers, the step size of pooling and training data size. Further, the shortcut layer can effectively solve the diversity reduction problem in a deep network. The hybrid network is shown to have a similar predictive performance to SWAT but is superior in wet seasons due to its nonlinear learning ability. This study shows that the hybrid network has great promise in learning nonlinear and high spatio-temporal variability in river flow forecasting.
Public policy: urban stormwater in a paradigm shift, is it the end or just the beginning?
Authors: Novaes Carlos , Marques Rui
Published: April 2022

The perception that urban stormwater policies are non-existent, incomplete, or lacking in aspects that concern the environment and quality of life in cities has become increasingly common. This is partly due to the increased frequency and magnitude of rainfall events resulting from climate change and its economic, social, and environmental consequences. Population concentration and changes in patterns of living, construction, and urbanization contribute to the pollution of water runoff and receiving waters. Thus, quantity and quality problems add up and often require costly solutions, which are then addressed as economic issues. To deal with all these aspects, many of which were previously absent, stormwater public policies require a paradigm shift to break away from institutional inertia and dependence on the previous path. Without the aim of exhausting the subject, this paper discusses the policy aspects that concern stormwater management and the current and desired paradigm shift.
DIGITAL CLUSTER MODEL OF PORE SPACE AT FLOW OF THREE-PHASE FLOW IN POROUS MEDIUM
Authors: SHABAROV Alexander B. , IGOSHIN Dmitry E. , Rostenko Polina M. , Sadykova Anastasia P.
Published: April 2022

The work is devoted to one of the urgent problems of the oil and gas industry — the study of three-phase filtration. The creation of pore space models is an important stage in the study of the flow of oil and gas mixtures for the subsequent determination of the filtration and reservoir properties of reservoir rocks. The aim of the study is to develop a physical and mathematical model of a porous medium on the scale of a core sample. A digital cluster model for calculating the geometric parameters of the pore space is presented. The structure of the pore space of the cluster model is based on the distribution of pores by diameters obtained from capillary pressure curves (KCD). The core contains clusters consisting of a big channel (B) through which oil, water and gas move in a clear mode, average channels (A) with moving water and gas and small channels (S) with moving gas, as well as bridges between these channels. The division of the pore diameter distribution function into regions related to big, average and small channels is based on empirically determined relationships between the numbers of channels through which fluids move in the pore space in the above combinations. At the same time, the transition from the physical core model to the digital cluster model is carried out with the preservation of porosity, absolute permeability and taking into account the tortuosity of the channels. The dependence of the tortuosity of channels on their diameter is assumed according to a decreasing power law. The model presented in this paper is tested on two examples at different values of effective porosity and the number of intervals of the pore distribution function by diameter. The model has the potential for further development and calculation of the filtration flow of a three-phase mixture (oil, gas and water) on the scale of a core sample.
Percutaneous mitral edge-to-edge repair
Authors: Golukhova E.Z. , Skopin I.I. , Latyshev M.S. , Slivneva I.V.
Published: April 2022

Functional mitral regurgitation, now better known as secondary mitral regurgitation, is the most common acquired heart disease in the world. In most cases, patients with secondary mitral regurgitation have a rather poor prognosis, for example, about 50% of patients are at high risk of surgery or are inoperable, while mortality within 1 year without surgery is 57%. The tactics of treating these patients is the subject of much debate. According to the American Association for Thoracic Surgery (Ischemic Mitral Regurgitation Consensus Guidelines Writing Committee), mitral valve reconstruction is accompanied by a large number of relapses of mitral insufficiency in the long term after surgery, and mitral valve replacement is characterized by high mortality (≥ 13%). With the optimal selected conservative therapy (Guideline-directed medical therapy), in most patients, there is no significant improvement in their condition. Since the 2000s the development of methods of interventional influence on the mitral valve for the treatment of such patients is underway. In the 2010s, interventional treatment techniques began to be widely used, and recommendations for their use began to be developed. In some cases, the results of using the techniques are superior to open surgery. Is it possible to say that the problem of treating patients with functional mitral insufficiency of high operative risk has been solved? In order to answer this question, a literature review was carried out on the interventional treatment of secondary mitral regurgitation using the "edge-to-edge" technique.We used PICO strategy (Patient, Intervention, Comparison, Outcome) for searching articles. A systematic search for information on the research topic was carried out in the PubMed and Google Scholar databases using search queries, keywords, and logical operators AND, OR. Key words: mitral regurgitation, functional mitral regurgitation, chronic mitral regurgitation, MitraClip, percutaneous mitral repair, mitral insufficiency, mitral valve, Edge-to-Edge repair. In the initial selection, 1,180 publications were received. After analyzing the titles and abstracts, 94 articles were selected, and full-text copies were studied. The final analysis included 43 articles and 2 randomized clinical trials. We have compiled a literature review on the interventional treatment of secondary mitral regurgitation using the "edge-to-edge" technique.Received 13 July 2021. Revised 4 August 2021. Accepted 9 August 2021.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.Contribution of the authors: The authors contributed equally to this article.
‘Print tuning’: Dé specifieke, leesgerelateerde ERP-component?
Authors: Maassen Ben A.M.
Published: April 2022

Overzichtsartikel van een serie studies in het kader van het themanummer 'Gevorderde lezers met dyslexie'.
ВОПРОСЫ РАСШИРЕНИЯ ПРИМЕНЕНИЯ ОТЕЧЕСТВЕННЫХ БАЗОВЫХ МАТЕРИАЛОВ В ИЗГОТОВЛЕНИИ ПЕЧАТНЫХ ПЛАТ
Authors: Дубровский А. , Егоров А.
Published: April 2022

Приводятся сведения о достижениях и планах российского производителя базовых материалов печатных плат – АО «Электромаш», о недавно созданной отраслевой ассоциации НАРПЭ, призванной содействовать расширению применения отечественных материалов в производстве печатных плат, а также о проблемах, решение которых данная ассоциация видит в качестве своей задачи.
A Detail Analysis of IoT Gas Detection System for Wireless Sensor Networks
Authors: Sharma Rajat , Sayyed Jishaan
Published: April 2022

Abstract: The Internet of Things (IoT) is basically a network that connects computing devices. IoT is capable of sending massive amounts of data via a network without the need for human intervention. Cloud services are used to manage this real-time data, which is backed up by strong computing software and hardware. This information is gathered through a variety of sensors placed around the user's environment. IoT is the future of computation, and it will have a significant impact on our daily life. In this research, we offer a wireless sensor network driven by the Internet of Things for gas detection. Using many sensors connected by IoT, these detectors can detect burnable, flammable, and toxic gases, as well as oxygen usage. This method is extremely adaptable when it comes to wirelessly accessing remote devices all across the world. Less power consumption and computational cost are advantages of this technology. Furthermore, it aids in the construction of open and compact stack sizes. Keywords: Wireless, Sensor, Communication, Network, IOT.
Impact of Covid-19 on IT Company
Authors: Yadav Kamlesh Dayashankar , Vishwakarma Dharmendrakumar Ramji
Published: April 2022

Abstract: This electronic document is about the impact of the IT industry during and before Covid-19 on the situation with the help of IT (Information Technology) solutions. India is one of the top world hubs of information technology enable services. Companies working in the service sector are also likely to be instantly impacted by the measures taken to contain the pandemic long time lockdown, and mobility restrictions. Keywords: IT, Company, Covid-19, Industry, Sector, Services
Secure the File Storage on Cloud Computing Using Hybrid Cryptography Algorithm
Authors: Dalave Chetan Vijaykumar , Lodh Anushka Alok , Dalave Tushar Vijaykumar
Published: April 2022

Abstract: The proposed of this paper is for the security needs of the cloud data center. Blowfish is used to convert encrypt file cuts, takes the minimum amount of time, and has the extreme throughput for encryption and decryption from other compatible algorithms. The idea of spreading and mixing meets the principle of information security. The hybrid approach makes the remote servers more secure when deployed in a cloud environment and, thus helps cloud providers gain more trust from their users. Used for data safety and privacy issues, the basic challenge of separating sensitive data and access control has been met. Cryptography techniques translate original data into an unreadable format. The encryption technique is divided into private key encryption and public-key encryption. Here we will use AES 128-algorithm, DES, RC, and LSB encryption techniques. This technique uses keys to translate data into an unreadable format. Therefore only authorized persons can access data from the cloud server. Ciphertext data is visible to all. Keywords: Cloud, AES, RSA, Blowfish algorithms, Encryption/Decryption Techniques.
Designing a Smart Bag Using Cyber Physical Devices
Authors: Sharma Prince , Jaiswal Himanshu Kumar , Tyagi Prashant , Mittal Pulkit , Shukla Shubham
Published: April 2022

Abstract: A smart bag is a specially designed bag that is tailored to a certain use and can benefit practically everyone in society. Smart implies clever, and the bag will be capable of carrying out a variety of functions for regular use. The bag developed uses renewable source of energy. The solar panel on the front of the backpack will not only charge electrical devices such as phones and laptops, but will also provide energy to the complete system. This energy helps in activating our cyber-physical device which consists of microcontrollers, sensors. As soon as the zip of the bag is opened, the microcontroller transmits the information to the user, using an android based application. It also sends a notification about the percentage of battery charged, in the bag using the solar panel to the user on their device Keywords: Smart bag, Microcontroller, Solar panel, Internet of Thing, sensors.
Truly Scalable and Reusable SOA Services
Authors: Parab Rajat
Published: April 2022

Abstract: Web Services are materialized as a major technology carried out for automated interaction between distributed and miscellaneous applications. It is defined as a software service that provides business solutions consumed by different service requester. It can be accessed by a standard web protocol. Service composition is the mechanism used for selecting, reusing and combining existing web services to build new web services. With immense increase in web services, quality assessment plays an essential role in the selection approach. QoS is defined as the ability to guarantee the requirements like latency, reliability, bandwidth, etc. in order to satisfy a service level agreement between an application provider and end-user. QoS based dynamic service composition leads to the upward growth of an organization that implements multiple services to provide its business solution. The proposed research work elaborates the research work on different methodologies of QoS prediction with its implications to provide a proper road map for future research on efficient service composition. Keywords: SOA, service reuse, scalable, web services, QoS.
PEDIATRIC RADIOLOGY
Authors: Editorial Article
Published: April 2022

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WATERMELON PEEL EXTRACT AS GREEN CORROSION INHIBITOR FOR ST-37 CARBON STEEL IN SEAWATER
Authors: Priharti Sri Teguh , Nizar Umar Kalmar , Sundari Rita , Etika Sri Benti , Oktavia Budhi , Putra Ananda , Anggraini Rini
Published: April 2022

Corrosion engineering has taken great interest in many industries that required high cost management to overcome the serious problems. This work has investigated the role of watermelon peel extract as green inhibitor to protect carbon steel in seawater. This investigation has studied the corrosion rate and inhibition efficiency applying weight loss method.  The laboratory result shows the optimum inhibition efficiency found to be 71.64% at 5% inhibitor concentration in 100 ml seawater at room temperature. The effects of temperature and immersion time on inhibition efficiency have also been examined.  This study has used Arrhenius equation based on activation energy to determine type of adsorption encountered with corrosion process. The result shows a chemical adsorption justified by its high adsorption heat and strengthened by FTIR and UV-Vis examinations. The phytochemical examination of watermelon peel extract gives positive response to flavonoid, alkaloid, and saponin. The finding is useful for many industries encountered with carbon steel corrosion in corrosive medium using green inhibitor.
Analysis of The Share Price of Transportation Companies Listed on the Indonesia Stock Exchange (IDX) Before and After Covid-19
Authors: Yuliana Dwi Riska , Khairunnisa Jihan Lathifah , Aslakhiyah Rubaiatul , Novitasari Sri
Published: April 2022

The Covid-19 virus pandemic has had a major impact on Indonesia, including on the economy, exchange rates and stock prices. On March 2, 2020, the first Covid-19 case was announced in Indonesia by President Ir. Joko Widodo. This study aims to analyze stock prices of Transportation Sector Companies Listed on the Indonesia Stock Exchange before and after Covid-19. In this study, the data used is the average share price of 41 transportation companies listed on the Indonesia Stock Exchange 31 days before and 31 days after the announcement of the first case of Covid-19 in Indonesia. The data was processed using the Wilcoxon Test, through the use of SPSS version 25. The results of data processing showed that there was a significant difference in stock prices before and before the announcement of the first Covid-19 case. This is indicated by a significance value of 0.000 < 0.05. Where the price is lower than before the first case of Covid-19 was announce.
STOCK PERFORMANCE ANALYSIS OF KOMPAS 100 BEFORE AND AFTER THE PANDEMIC COVID-19 IN INDONESIA
Authors: Setiawan Teguh Agus , Haliza Siti Nur , Mulki Nur' Alvia , Suhadiono Suhadiono
Published: April 2022

AbstractThis study analyzes the performance of the Kompas 100 stock before and after the COVID-19 pandemic in Indonesia in the period 2019 – 2020. This study uses stock price data for 40 companies listed in the Kompas 100 stock group on the Indonesia Stock Exchange. Data were analyzed using IBM SPSS Version 25 with a paired sample difference test model (compare means paired samples t test). This study found that there were differences in the situation before and after the COVID-19 pandemic on the volatility of the Kompas 100 stock price on the Indonesia Stock Exchange. In general, there has been a decline in the share price of Kompas 100 on the Indonesia Stock Exchange which reached -12.46% after the pandemic in 2020 compared to before the COVID-19 pandemic situation in 2019.
COMPARISON ANALYSIS OF LQ-45 SHARE PRICES BEFORE AND DURING THE COVID-19 PANDEMIC
Authors: Gabrilia Filia , Octavia Anita Dwi , Meliala Melinda S , Sumaiya Annisa
Published: April 2022

The COVID-19 pandemic has impacted the world of capital markets, especially in LQ45. The company's share price globally, the Indonesian state, also experienced an unprecedented decline. The purpose of this study is to analyze the impact of the COVID-19 pandemic on LQ45 shares by comparing the average price of LQ45 shares before and after the COVID-19 pandemic in Indonesia. This study uses IBM SPSS Version 22 with a different pair-sample test model (compare means paired sample t-test). The results of this study indicate that the decline in stock prices in LQ45 shares before and after the COVID-19 pandemic reached Rp1,234.76.
ANALYSIS OF PURCHASE DECISION MODEL TOWARDS AIRLINES TICKET BOOKING IN TRAVELOKA (MERCU BUANA UNIVERCITY CASE STUDY)
Authors: Pringgodigdoyo Prapatantio Teteg , Nurmahdi Adi
Published: April 2022

Traveloka is an airline ticket purchase application that has the most visitors in Southeast Asia, but starting in the first quarter of 2019 they experienced a decline in the number of visitors. The decline in the number of visitors was the most contributed by application users from Indonesia. The decline in the number of visitors is a phenomenon that needs attention because it can potentially affect ticket sales through the application. there are several factors that influence the pattern of ticket purchases through online applications, including internet knowledge, service quality, prices, trust, understanding of risk, and user perceptions.  The objectives in this study is to determine the effect of price, service quality, brand image on purchase decisions on the Traveloka application. The samples of this study are a 100 post graduate students of Mercu Buana University. The results of this study show that price does not have a positive and significant effect on brand image on the Traveloka application. Price, service quality and brand image have a positive and significant influence on purchase decisions on the Traveloka application. Traveloka companies are advised to increase their responsiveness in providing quality services so that they will be able to create a better brand image. Keywords: price, service quality, brand image, purchase decision, traveloka
THE INFLUENCE OF INVESTMENT KNOWLEDGE, INVESTMENT MOTIVATION AND FINANCIAL LITERATURE ON INVESTMENT INTEREST (CASE STUDY IN INDONESIA STUDENTS WHO HAVE INVESTED)
Authors: Sumaiya Annisa , Meliala Melinda S , Setiawan Teguh Agus
Published: April 2022

ABSTRACTThe purpose of this study is to determine whether there is a relationship between investment interest based on investment knowledge, investment motivation and financial literacy. The investment interest variable is the dependent variable. Meanwhile, investment knowledge, investment motivation and financial literacy are independent variables in this study. Processing research data using multiple regression method through SPSS software. Based on the results and conclusions of this study, investment knowledge does not have a significant effect on student investment interest in the capital market. Meanwhile, investment motivation and financial literacy have a significant influence on investment interest in the capital market.
THE ACCURACY TEST OF TECHNICAL ANALYSIS OF MOVING AVERAGE, BOLLINGER BANDS, AND RELATIVE STRENGTH INDEX ON STOCK PRICES OF COMPANIES LISTED IN INDEX LQ45
Authors: Daniswara Dipta Amelia , Widjanarko Hendro , Hikmah Khoirul
Published: April 2022

This study aims to test and provide empirical evidence of the accuracy of the technical analysis indicators Moving Average, Bollinger Bands, and Relative Strength Index in predicting the direction of stock price movements. This research focuses on stocks that represent the Indonesian stock Market, namely the LQ45 stock index for the period February 2021 - July 2021. Data were collected through the tradingview.com platform. To test the research hypothesis, the statistical differences between the predictions and the reality of stock price movement were tested using Mann-Whitney non-parametric test. The results of this study found that there was no difference between the predictions of the direction of stock price movements produced by the three indicators and the actual prices, which means that the three indicators are accurate. From the results of the analysis and comparison of the performance of the three indicators from the number of signals, the average rate of return, and the sample observations, it can be concluded that the Relative Strength Index indicator has a more optimal accuracy performance compared to the other two indicators. indicator. The results of this study can be used as a reference for capital market investors in choosing technical analysis methods that can help make more appropriate investment decisions.
DEVELOPMENT OF WORKLOAD ANALYSIS MODEL ACCORDING TO JOB MAPPING FOR HUMAN RESOURCES OPTIMALIZATION BASED ON EMPLOYEE’S COMPETENCIES AT BBPPMPV BMTI
Authors: Wanto Wanto
Published: April 2022

All of employees at Vocational Education Quality Assurance Development Center from the Leadership to the Executor structure, work in accordance with the job mapping whose number and workload have been determined by the government. However, in daily tasks there are still employees who work overload and some are underloaded. So far, the workload of employees is determined by regulations which mostly calculate the employee's burden based on the physical workload, while the calculation of the workload based on the mental workload has barely been touched. The purpose of this study is to understand how to develop a workload analysis model according to job maps for optimizing human resources based on employee competencies. The formulation of the issue on this study is how to develop a workload analysis model according to the job map for optimizing human resources based on employee competencies. Analysis of the models is done by examining the existing workload analysis models, then making comparisons between each model, where the research step begins with a literature study and field observations. The development of the model is carried out by the following steps: determining the objectives or defining the problem, making a conceptual model, formulating the model, analyzing and the model solving, as well as the use of models. where the research step begins with a literature study and field observations. The development of the model is carried out by the following steps: determining the objectives or defining the problem, making a conceptual model, formulating the model, analyzing and the model solving, as well as the use of models. where the research step begins with a literature study and field observations. The development of the model is carried out by the following steps: determining the objectives or defining the problem, making a conceptual model, formulating the model, analyzing and the model solving, as well as the use of models.
“In Our Home Everyone Said Lévin”: on the Pronunciation of the Surname of Anna Karenina’s Character in L. N. Tolstoy’s Family
Authors: Mozharova Marina A. , Sin Anastasia V.
Published: April 2022

The article deals with the issue of correct pronunciation of the surname of Konstantin Levin — a character from L. N. Tolstoy’s novel Anna Karenina. According to the writer’s youngest daughter A. L. Tolstaya and his great grandson I. V. Tolstoy, the author of the novel and all his family pronounced it like “Lévin.” This tradition is currently preserved in the L. N. Tolstoy State Museum in Moscow and in L. N. Tolstoy Museum-Estate ‘Yasnaya Polyana’. Apart from the spoken tradition there is also a written tradition originated from L. N. Tolstoy himself. Manuscripts of Anna Karenina attest to the fact that L. N. Tolstoy, S. A. Tolstaya and all other copyists always wrote “Levin,” letter “ё” (“yo”) being used in necessary cases. N. N. Strakhov who helped L. N. Tolstoy prepare the first separate edition of Anna Karenina (1878) wrote in the same manner. The tradition of spelling the surname of the character as “Levin” is registered in all lifetime and posthumous editions of Anna Karenina as well as in translations into foreign languages. However there is a contradiction in spelling “Lyovin” in two private letters of L. N. Tolstoy’s contemporaries (I. S. Aksakov and K. N. Leontiev), who were not in his inner circle, and a viewpoint of V. V. Nabokov claiming that L. N. Tolstoy derived the character’s surname from his own name Lyov used at home.
“Gospel Story”: The Broad Intention of St. Theophan (Govorov) and Ways of Its Implementation
Authors: Shcherbakova Marina I.
Published: April 2022

The article discusses the ways and methods of implementing the plan of St. Theophan to compose the Gospel story according to the four canonical books of the evangelists Matthew, Mark, Luke and John. The creative history of the book is restored on the basis of St. Theophan’s letters to the Athos monk Arseny (Minin) and N. V. Elagin, as well as the bishop’s articles “Lessons from the deeds and words of the Lord and God and our Savior Jesus Christ” and “Instructions according to which everyone can compose a consistent Gospel story from the four Gospels by himself.” An analysis of the four-part structure of the book is undertaken. As an example of St. Theophan’s deep reading of the gospel text, the stories about the calling of fishermen by the Lord, about His visit to the house of Martha and Mary and the farewell conversation with the disciples are considered. A kind of inserted episode of creative history was revealed — St. Theophan’s editing of the famous three-volume work of the same name by Archpriest Pavel Matveevsky. The main feature of St. Theophan’s work, in comparison with the other Gospel stories, consists in the distribution of events into periods and departments, not so much by the time of their accomplishment, but by place.
Challenges faced by hospital management boards: A case of central hospitals in the emerging market
Authors: Funhiro Webster , Yalezo Bhasela , Mutambara Emmanuel
Published: April 2022

Zimbabwe’s health care sector has been on the decline since the attainment of political independence in 1980 with the blame leveled against the hospital’s governance system. Responding to the blame, The Ministry of Health and Child Care, responsible for all public hospitals in Zimbabwe, has revamped the hospital governance system by introducing what is referred to as the hospital management board (HMB) tasked with the responsibility to provide the oversite role (Moyo, 2016; Sikipa, Osifo-Dawodu, Kokwaro, & Rice, 2019). The study, therefore, sought to establish the challenges faced by HMBs in the management of public hospitals with a focus on six (6) central hospitals in Zimbabwe. A mixed-method design was employed using the questionnaire and interviews to collect data from 66 censured board members for the quantitative study, and 12 purposively selected board members for the qualitative study. The study revealed that HMBs faced numerous challenges that include an unconducive economic environment responsible for high costs in hospital health care and services, ineffective policies, a weak referral system, and inexperienced board members. The study recommends that HMBs should be appointed based on relevant experience in public hospital leadership. Drawing from the findings, most HMBs must be reconstituted to include members with relevant experience, a focus on policy issues towards improving the ineffective hospital referral system.
Utilización de plasma de convaleciente en pacientes con neumonía por sars-cov-2. Serie de casos
Authors: J M Cavallo , P Lucero
Published: April 2022

INTRODUCCIÓN: El virus que causa COVID-19 es denominado síndrome respiratorio agudo y grave porcoronavirus 2 (Sars-CoV-2). Con múltiples estudios respecto a diversos tratamientos (sintomáticos oantivirales) de cuestionable evidencia y resultados clínicos no aplicables a la población general, emergió lanecesidad de un tratamiento específico que mejore verdaderamente la historia natural de la enfermedad. 1,2El plasma convaleciente (PC) parece al día de la fecha una de las respuestas a esta necesidad. Se obtiene apartir de donantes que se han recuperado de la infección y que hayan generado anticuerpos contra ella(medidos en sangre como IgM e IgG específicos para Sars-CoV-2). 3,4OBJETIVO: Reportar la evolución clínica de pacientes con neumonía bilateral por COVID-19 querecibieron PC.MATERIAL Y METODO: Se analizó de manera retrospectiva la evolución clínica de 6 pacientesinternados con diagnóstico de COVID-19. Todos ellos tenían neumonía bilateral. Recibieron 1 o 2 unidadesde PC ajustadas al peso y se reevaluaron los pacientes a las 72 horas y hasta la externación.RESULTADOS: A los pacientes se les administró PC. A las 72 horas de la infusión de PC a nivel clínicolos pacientes presentaron mejoría de la disnea hasta la desaparición de la misma, y un menor requerimientoen el flujo oxígeno. También a nivel analítico los pacientes mejoraron de manera evidente a las 72 horas.CONCLUSIONES: Los riesgos de la infección por COVID-19 son importantes. La información respectoal PC en pacientes con COVID-19 es escasa, aunque los datos preliminares actuales son prometedores.Además, la infusión de PC es respaldada por amplia evidencia respecto al uso de PC en otras infeccionesvirales por coronavirus (MERS, SARS) con extenso uso y excelentes resultados. Sin embargo, esimportante realizar estudios clínicos controlados, aleatorizados y sistematizados para confirmar estaeficacia.
Significance of anti-neutrophil antibody in chronic benign neutropenia in Chinese children
Authors: Ha Shau yin , Lai Sophie , See Wing Shan , Duque Jaime , Cheuk Daniel Ka Leung , Ho Jenny , Cheung Stephen , Chu Patrick , Lee Pamela PW , Kwok Janette SY
Published: April 2022

Background: Chronic benign neutropenia (CBN) and autoimmune neutropenia
(AIN) are notoriously difficult to differentiate in children owing to
their indistinguishable clinical course and varying availability and
accuracy in the methods of anti-neutrophil antibody detection. This
study aims to investigate whether the presence of anti-neutrophil
antibody has implications on the disease course in Chinese children with
AIN, as well as evaluating the various methods including LABScreen
MULTI, granulocyte agglutination test (GAT) and granulocyte
immunofluorescence test (GIFT) in anti-neutrophil antibody detection.
Procedure: Chinese children under 18 years of age with neutropenia ≤ 1.5
x 109/L lasting 6 months or more in our single center were recruited
into the study between 2016 to 2018. Patients with secondary causes of
neutropenia were excluded. Blood for anti-neutrophil antibody and
genotyping was taken once at the time of recruitment and subsequently
when neutropenia recovered to ≥ 1.5 x 109/L. A combination of two
in-house methods including GIFT, GAT and commercial kit LABScreenTM
multipanel were used for the detection of antibodies. The age of onset,
age of recovery, duration of neutropenia, gender, serial neutrophil
counts, incidence of invasive infection, use of G-CSF were examined.
Results: Using combined testing methods, anti-neutrophil antibody was
detected in 30.8 % of patients and positivity was associated with more
severe neutropenia, higher likelihood of infection and slower and later
recovery compared to those without antibodies. Conclusions: The presence
of anti-neutrophil antibody was useful in predicting the clinical course
of patients with AIN. The use of combined testing methods increased the
detection rate.
Scabies surrepticius: An uncommon presentation of a common dermatosis
Authors: chaima kouki , Korbi Mouna , Manaa Linda , Njim Leila , Mohamed Mariem , Belhadjali Hichem , Zili Jameleddine
Published: April 2022

We report an atypical presentation of a current disease to highlight the
importance of making a correct diagnosis of scabies surrepticius in
front of any itchy dermatosis especially in elderly patients. The
misdiagnosis of this disease results in extensive infestation,
especially with the use of corticosteroids.
Intramucosal esophageal dissection caused by gastric tube insertion
Authors: Ichibayashi Ryo , Watanabe Masayuki , Honda Mitsuru
Published: April 2022

We experienced a case of iatrogenic intramucosal esophageal dissection
in a patient who had difficulty inserting a gastric tube. CT is useful
for diagnosis.
Eosinophil-Rich Sweet syndrome: Is it a new entity?
Authors: Korbi Mouna , Chtiou Emna , Soua Maroua , Hadhri Rym , Belhadjali Hichem , Youssef Monia , Laatiri Mohamed Adnène , Mohamed Mariem , Zili Jameleddine
Published: April 2022

Sweet syndrome (SS) is an inflammatory disease with clinical and
histological characteristics. SS is usually associated with important
neutrophilic infiltrates on histological examination of skin biopsies. A
few cases of SS with dense eosinophil infiltrate have been described.
Herein, we report a new case of eosinophil-rich SS.
Estimation of breeding population size using DNA-based pedigree reconstruction in brown bears
Authors: Shimozuru Michito , Jimbo Mina , Adachi Keisuke , Kawamura Kei , Shirane Yuri , Umemura Yoshihiro , Ishinazaka Tsuyoshi , Nakanishi Masanao , Kiyonari Mayu , Yamanaka Masami , Amagai Yukihiro , Ijuin Ayaho , Sakiyama Tomoki , Kasai Shinsuke , Nose Takane , Shirayanagi Masataka , Tsuruga Hifumi , Mano Tsutomu , Tsubota Toshio , Fukasawa Keita , Uno Hiroyuki
Published: April 2022

Robust estimates of demographic parameters are critical for effective
wildlife conservation and management, but are difficult to obtain for
elusive species. We estimated the breeding and adult population sizes,
as well as the minimum population size, in a high-density brown bear
population on the Shiretoko Peninsula, in Hokkaido, Japan, using
DNA-based pedigree reconstruction. A total of 1,288 individuals,
collected in and around the Shiretoko Peninsula between 1998 and 2020,
were genotyped at 21 microsatellite loci. Among them, 499 individuals
were identified by intensive genetic sampling conducted in two
consecutive years (2019 and 2020) mainly by noninvasive methods (e.g.,
hair and fecal DNA). Among them, both parents were assigned for 330
bears, and either maternity or paternity was assigned to 47 and 76
individuals, respectively. The subsequent pedigree reconstruction
indicated a range of breeding and adult (≥4 years old) population sizes:
128–173 for female breeders and 66–91 male breeders, and 155–200 for
female adults and 84–109 male adults. The minimum population size was
estimated to be 449 (252 females and 197 males) in 2019. Long-term
continuous genetic sampling prior to a short-term intensive survey would
enable parentage to be identified in a population with a high
probability, thus enabling reliable estimates of breeding population
size for elusive species.