bluuebunny/crossref_metadata_2025 huggingface dataset:
Temporal changes of taxonomic and functional diversity in dung beetles inhabiting forest fragments and pastures in Los Tuxtlas Biosphere Reserve, Mexico
Authors: Da Silva Pedro Giovâni , P. Salomão Renato , González-Tokman Daniel , S. Neves Frederico , Favila Mario E.
Published: June 2023

We evaluated short- (among months within-years) and long-term (between 1999-2000 and 2016-2017) temporal patterns of taxonomic and functional β- diversity (and its components of substitution and gain/loss) of dung beetle assemblages in forest  fragments and pastures in the Los Tuxtlas Biosphere Reserve (LTBR). Habitat type affected the taxonomic dissimilarity and the richness difference component, with average values being respectively 1.42 and 1.56 times higher in pastures than in forest fragments. Only habitat type was important for functional  richness, being 1.93 and 1.69 higher in forest fragments than pastures in 1999-2000 and 2016-2017, respectively. Pastures were taxonomically and functionally poorer but were also more temporally dynamic than forest fragments both within-year and between-years. Habitat type is a determining factor for temporal dynamics, with forest fragments presenting more stable dung beetle assemblages than cattle pastures.
Crinoideos (Echinodermata: Crinoidea) del Misisípico-Pensilvánico de la sierra Santa Teresa, región central del estado de Sonora, México
Authors: Buitrón-Sánchez Blanca Estela , Cuadros-Mendoza Iván Manuel , Cuen-Romero Francisco Javier , Torres-Martínez Miguel Ángel
Published: June 2023

Se describen crinoideos de las morfoespecies Baryschyr anosus Moore y Jeffords, Cyclocaudex insaturatus Moore y Jeffords, Floricyclus angustimargo Moore y Jeffords, Cyclocion distictus Moore y Jeffords, Lamprosterigma erathense Moore y Jeffords y Preptopremnum rugosum Moore y Jeffords que proceden de estratos del Misisípico Superior (Chesteriano) y del Pensilvánico Inferior-Medio (Morrowano-Desmoinesiano) de la sierra Santa Teresa, Sonora. La distribución de estas morfoespecies permitió establecer correlaciones paleobiogeográficas con otros crinoideos reportados para el Carbonífero del norte de México en los cerros El Tule, sierra Las Mesteñas, sierra Agua Verde en Sonora. También son correlacionables con regiones de EUA como en Texas, Colorado, Illinois, Oklahoma y Kansas pertenecientes a la provincia del Cratón Norteamericano. Asociado a los crinoideos existe una abundante y diversa biota representada por algas, foraminíferos-fusulínidos, esponjas-quetétidas, corales, briozoarios-fenestélidos, braquiópodos-prodúctidos y conodontos que se desarrollaron en los bordes continentales de plataforma calcárea en mares tropicales del océano Rheico durante el Paleozoico Tardío.
Entre la revolución y la institución: la Escuela Popular de Arte en Puebla, 1973-1974
Authors: López Cuenca Alberto Javier , Márquez Carrillo Jesús
Published: June 2023

Este artículo tiene por objetivo reconstruir someramente y problematizar críticamente la Escuela Popular de Arte (EPA), una efímera y poco estudiada iniciativa de pedagogía artística desarrollada en Puebla a inicios de la década de 1970. Mediante revisión bibliográfica, hemerográfica y entrevistas a actores directos, emplazaremos la epa, por una parte, en las disputas de distintos movimientos de izquierda por el control de la Universidad Autónoma de Puebla; por otra, en los compromisos de profesores, alumnos y personal universitario con los movimientos de resistencia ciudadana que respondían al acelerado y desigual proceso de industrialización en la ciudad y las zonas rurales colindantes; finalmente, la situaremos en la estela de las formas de autoorganización artística y experimentación plástica puestas en práctica en las movilizaciones de estudiantes de 1968. Una vez hecho esto, interrogaremos el que quizá fue el principal reto en la fugaz existencia de la epa: la imposibilidad de institucionalizar la experimentación artística y el compromiso político como estrategia educativa.
José María Carvajal y la construcción del Estado nacional en la frontera norestense, 1859-1860
Authors: Tovar Mota Valentina
Published: June 2023

El objetivo de este artículo es mostrar el papel militar y político que tuvo José María Carvajal en la frontera norte de Tamaulipas entre 1859 y 1860 durante la guerra de Reforma. El trabajo argumenta que, en sus intervenciones como militar, Carvajal interactuó con fuerzas políticas y sociales de gran alcance de índole regional, nacional e internacional. A través de un análisis de fuentes hemerográficas y de documentación resguardada por el Archivo Histórico de la Secretaría de la Defensa Nacional, el artículo permite adentrarse en la manera en la que personajes como Carvajal contribuyeron a apuntalar la causa liberal en la zona fronteriza y a construir autoridad para el gobierno encabezado por Benito Juárez. El artículo concluye que la facción liberal en buena medida intentó construir legitimidad y controlar las zonas fronterizas a través de figuras “fuertes” como Carvajal, las cuales fueron pieza clave del dominio territorial en esa parte de la línea divisoria.
Sobre Luis Alberto Arrioja Díaz Viruell y Armando Alberola Romá, eds., Estudios sobre historia y clima: Argentina, Colombia, Chile, España, Guatemala, México y Venezuela
Authors: Lorenzo Río María Dolores
Published: June 2023

Reseña sobre Luis Alberto Arrioja Díaz Viruell y Armando Alberola Romá, eds., Estudios sobre historia y clima: Argentina, Colombia, Chile, España, Guatemala, México y Venezuela (Zamora, Michoacán: El Colegio de Michoacán; Alicante: Universidad de Alicante; San Luis Potosí: El Colegio de San Luis; México: Instituto de Investigaciones Dr. José María Luis Mora, 2021).
Sobre Silvia Marina Arrom, La Güera Rodríguez. Mito y mujer
Authors: Tuñón Pablos Julia
Published: June 2023

Reseña sobre Silvia Marina Arrom, La Güera Rodríguez. Mito y mujer (México: Turner Noema, 2020).
Communication Network with Secure, Reputable Mobile Agent Structure
Authors: Yadav Neera , Singh Dharamveer , Kumar Anil
Published: June 2023

Abstract: The proposed multiphase security model for mobile agents appears to address a critical issue in their mainstream deployment. The use of symmetric key cryptography is a sensible choice for securing mobile agent code and data, as it is more efficient than asymmetric key cryptography. The focus on defending against a meet-in-the-middle attack is also appropriate, as this is a common type of attack that mobile agents are vulnerable to. However, it would be helpful to provide more details about the specific authenticated encryption mechanism that will be used. This will help to evaluate the effectiveness of the proposed model and ensure that it is robust enough to defend against various types of attacks. It is also important to consider the energy consumption of the proposed security model, as mobile devices typically have limited battery life. Therefore, the model should be designed in a way that minimizes energy consumption while maintaining the required level of security. Overall, the proposed multiphase security model appears to be a step in the right direction for addressing the security issues associated with mobile agents. However, it is important to ensure that it is properly implemented and thoroughly tested to ensure its effectiveness and efficiency
Universal Language Model Fine-Tuning for Text Classification
Authors: Reddy R Neha
Published: June 2023

Abstract: We describe approaches that are essential for fine-tuning a language model further utilized for text categorization and propose Universal Language Model Fine-tuning (ULMFiT), an efficient transfer learning method that can be used for any NLP activity. Transfer learning methods have greatly impacted computer vision, but existing approaches in NLP still require taskspecific modifications. Universal Language Model Fine-tuning, or ULMFiT, is an architecture and transfer learning method that can be applied to NLP tasks. It involves a 3-layer architecture. Three steps make up the training process: pre-training for the general language model on a text taken from Wikipedia; fine-tuning the language model on a target task; and fine-tuning the classifier on the target task. Deep learning techniques enable computers to learn and comprehend natural language, facilitating human-machine interaction. Deep learning models are often employed in medical research, from medication candidate identification to picture analysis. On text classification tasks, our method greatly surpasses the state-of-the-art (it is the most recent model incorporating the best and latest technology), reducing the error on most datasets. Furthermore, with only a few labeled examples, it can match the performanceof training on 100× more data.
Study of Image Recognition Using Machine Learning
Authors: Deshmukh Shubhangi C.
Published: June 2023

Abstract: This article presents a survey of machine learning for image recognition. Image Recognition is the task of identifying objects of interest within an image and recognizing which category the image belongs to. The common goal of image recognition is the classification of detected objects into different categories. Image processing technology based on machine learning has been widely used in feature image, classification, segmentation and recognition and is a widely used in various fields. In this paper use of machine learning for image recognition is discussed.
Virtual Assistant Using Supervised Learning
Authors: Ali MD Mohsin , Vamshi S. , Shiva S. , Prakash S. Bhanu
Published: June 2023

Abstract: Todays modern world, everything got evoluted including technology from vacuum tubes to nanoelectronics.Now a days the total world is in single palm of human in the form of mobile.But these days we aren’t using hands, instead we using voice commands to wake electronics devices like mobiles,it is not only in mobiles, also in every electronics.This type of usage is possible by embedding a virtual assistant into electronics. Virtual Assistants are software programs that help you ease your day to day tasks, such as showing weather report, creating reminders, making shopping lists etc. They can take commands via text (online chat bots) or by voice. This paper delivers steps to build a web based virtual assistant using supervised learning to achieve goals which cannot done by the VA’s in market.And as this model uses supervised learning, so there will be limited commands and data to maintain it in our control.
An Approach of Continued Involvement and Continued Development Using Cloud Computing for University-Industry Collaboration
Authors: Thaker Dhaval J. , Raval Dr. Hiteshkumar R.
Published: June 2023

Abstract: Education is strange for any country’s growth. Nowadays technology is growing rapidly. Technology plays a very important role in every domain of industry, especially in higher education where there is a need to improve the quality of education. Continuing updating in technology is essential to adopt by education institutions. Education 4.0 and 5.0 are focused on providing value-based, skill-based education according to the needs of the industry. Cloud computing helps to make a bridge between university and industry. Cloud computing has such a kind of characteristic, service model, and deployment model which helps to continued involvement and development (CI/CD) to UI. Our research discussed the role of continued involvement and continued development by the university and industry using cloud computing.
Contours and Strokes of Islamic Social Policy
Authors: Stepanyants Marietta T.
Published: June 2023

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Master of Adab about Art of Writing: Preface to Publication of Translation of Abu Hayyan al-Tawhidi’s Manuscript “An Epistle on Penmanship”
Authors: Palenko Mikhail S.
Published: June 2023

There is given a short review of the most important biographical information about Abū Ḥayyān al-Tawḥīdi (d. ca. 1023), an outstanding representative of the Adab literature. Amongst his creative heritage it is emphasized the importance of the «Epistle (on Penmanship)». The conclusion is made that Adab style served in the best way the author’s intention. He was the first one who succeeded to exhaustively summarize the primary (defining) stage of the Arabic script formation, to clearly formulate the technique for preparing the qalam . The “Epistle” is written in a simple manner, though it is not devoid of traditional elegance and eclecticism. Anticipating further development of the multiple types of proportional script referring to the existent schools, al-Tawḥīdi formulates common additional principles (apart from proportions), that, according to him, would constitute their aesthetics in future. In the second part of the “Epistle” there are given classic sayings and teachings, that became commonplace, regarding this type of art. Al-Tawḥīdi goes beyond his contemporaries and authors of the inner tradition. He gives the full scope of then existing knowledge regarding the discourse object. These data can be divided into rubrics depending on the subject and genre. In many of them we can trace the author's desire to zealously protect the Arab cultural heritage. It is concluded that al-Tawḥīdi strived to take out and convey further the main information, rules and techniques from the previous era of styles formation, so that they would not be lost or significantly changed. The writing contains numerous terms related to the preparation of tools and the process of script itself, which may again become relevant in the modern science of calligraphy.
An Epistle on Penmanship. Translated from Arabic with commentary by M.S. Palenko
Authors: Abu Hayyan al-Tawhidi , Palenko Mikhail S.
Published: June 2023

For the very first time, Russian readers are offered the translation of one of the most rarely published (in the Arab world) and practically unknown (everywhere else) works of Abū Ḥayyān al-Tawḥīdi (930-1023), “[An Epistle] on Penmanship (Arabic Calligraphy)” (982). As one of those who popularized knowledge, an encyclopedist, an unrivaled master of style and a Mu’tazilite scholar Al-Tawḥīdi, using Adab literature, shares all that was known to him about this form of Arabic literature up until its compilation. In an elegant manner, he reveals its secrets, gives us valuable recommendations, and conveys the universal admiration of the famous sages, writers, scribes, and court secretaries of that time. This epistle is considered the first professional work of this art form in the Arab tradition. At the time this piece was written, the seven “canonical” types of Arabic writing were not yet developed in the form and with the names, we are familiar with now. Nevertheless, this is what makes this treatise even more precious in raising the Adībs as well as the well-educated urban youths of those days. It sheds light on the history of their creation at the initial and, perhaps, the most crucial stage. The theoretical basis and the most important rules of proportional writing were formed back then and remain unshakable to this day.
Captiveness and Openness as Ontological Intuitions in Works of H. Bergson
Authors: Litvinov Maksim F.
Published: June 2023

The research focuses on the problem of freedom from that point of view which puts captiveness by being and openness to being in the middle of non-dialectical examination. This perspective clarifies not only the major course of Bergson’s thought, but also the subsequent incorrect shift to the pole of openness in the hermeneutical interpretation of facticity, implemented by Heidegger. The work is conventionally divided into two parts. The first one inquires about specifics of the method used by Bergson. It is emphasized the proximity in between Bergson's orientation to the common sense and phenomenological research, despite all differences in these approaches. Also it’s gives a general analysis of Bergson’s concepts used in “Time and Free Will: An Essay on the Immediate Data of Consciousness” and in “Matter and Memory” in order to adequately questioning about the freedom of a person, acting on the basis of specific practical conditions of his existence. Bergson draws the roads of freedom through the adaptability of the intelligible to the prose of life, establishing the plane of immanence with its unbreakable boundaries. The second part analyzes aesthetic consequences of Bergson’s theory of perception and memory, thus opening access to descending pathways in sensory data processing. The theory of duration and the emphasis it places on retrospection in clarifying what accompanies the act of perception, argues for the connection of creativity with the process of actualization of the virtual. With reference to Deleuze, it is criticized the irrational attempt to assert the beginning of creativity both in nothingness and in the realization of the possible by its limiting. Thus, the appeal to Bergson’s ontological intuitions allows to refuse both the aesthetics of the origin and the logic of the readiness-to-hand-being as primarily encountered in the world. In conclusion, it is considered Bergson's polemic with Einstein, in the resolution of which the logic of differentiation seems preferable to the logic of dialectical sublation.
Hegel’s Bellicis View of War. Mature Works
Authors: Krouglov Alexei N.
Published: June 2023

In “The Phenomenology of Spirit” and “Philosophy of Right”, Hegel gives a detailed specification of the theses about the war that were claimed in earlier papers and manuscripts, but his position is not fundamentally changed. In the “The Phenomenology of Spirit” Hegel advocates governments’ need and right to initiate a war from time to time in order to prevent both the isolation and atomization, and let individuals feel the death. As in the past, the war, as Hegel says, has a moment of ethical life. In the “Philosophy of Right” Hegel introduces final deliberations about war that rely on ideas of his earlier paper about natural law even more than in the “The Phenomenology of Spirit”. Hegel emphasizes the ethical role of sacrifice in the war and expresses opinions critical of not an abstract perpetual peace but a concrete philosophical project of Kant. Due to Hegel, Kant’s perpetual peace does not resemble a perpetual deception, since the required union of states is elusive and none except the world spirit in the world history can be a praetor. In line with Heraclitus, Hegel maintains that wars underlie the nature of things. I contribute to the discussions of Hegel scholars if Hegel’s philosophy glorifies a war or not as follows: I substitute the term “glorification” with the term “bellicisme” that suits better to measured, not snobbish and deprived of certain historical implications Hegel’s theses about reasonableness, necessity, the ethicality of war and ethicality of perpetual peace illness.
Diseminasi Hasil Budidaya Madu Lebah Bagi Meningkatkan Produktivitas Daya Saing Produk Berbasis E-Commerce Pada UKM Madu “Dr.Bee” Danau Lamo Kecamatan Maro Sebo
Authors: Setiawan Dedy , Arsa Daniel , Fitri Lucky Enggrani , Weni Indra
Published: June 2023

Masyarakat lokal di kecamatan. Mendahara Ulu di masa pandemic virus covid 19, banyak mencari peluang bagi meningkatkan taraf perekonomian mereka. Salah satunya dengan melakukan pembudidayaan madu lebah. usaha mikro kecil HoneyMoon Madu yang di pimpin oleh Ibu Resti Ismaya yang berlokasi di desa Sungai Beras Kecamatan Mendahara Ulu Kabupaten Tanjung Jabung Timur merupakan salah satu usaha mikro kecil yang bergerak dalam pembudidayaan lebah madu. Permasalahan utama yang dihadapi oleh mitra pada saat ini adalah: (1). Usaha Mikro Kecil HoneyMoon Madu dalam hal mempromosikan produk-produknya masih mengunakan cara yang sangat sederhana sekali (bersifat Offline) sehingga jangkauan pemasaran tidak begitu luas hanya sebatas di dalam provinsi Jambi saja. Pemasaran produknya yang di lakukan oleh mitra hanya dari mulut ke mulut (word of mouth), belum menggunakan media teknologi berbasis online (E-Commerce) yang dapat dengan mudah membantu dalam memasarkan produknya (2). Mitra usaha mikro kecil HoneyMoon Madu membutuhkan pelatihan tentang manajemen pemasaran, manajemen produksi dan permodalan serta pelatihan dalam penggunaan teknologi khususnya teknologi informasi dan komunikasi untuk digunakan dalam membantu tatakolah manajemen pada mitra dan memasarkan produk-produknya secara online (3). kemasan untuk produk madu yang dimiliki mitra kurang menarik dan kurang higienis. Luaran dari kegiatan pengabdian masayarakat ini adalah metode dalam tata kelola manajemen bagi meningkatkan produktivitas madu serta penyedian kemasan yang higenis dan menarik dan pembuatan teknologi tepat guna berupa sistem e-commerce berbasis web selain itu target pengabdian ini, dalam besinergi dengan kegiatan Merdeka Belajar Kampus Merdeka Universitas Jambi yaitu Desa Binaan dan Magang.
Práticas translíngues em perspectiva dialógica
Authors:   , Padilha Mariana Aparecida
Published: June 2023

Ao considerar o campo da educação bilíngue, observam-se diversas questões que impedem e dificultam a implantação efetiva de outras metodologias e conceitos acerca dos campos da educação e da linguagem. Os professores são frequentemente confrontados com alguns obstáculos ao lecionar, visto que as instituições preservam abordagens que analisam o educando e os seus conhecimentos de forma categórica. Muitas vezes, a falta de esclarecimento e posicionamento pela gestão pedagógica para a aplicação de métodos diferenciados, além da baixa ou inexistente oferta de formação continuada para professores, promovem um ambiente com limitações para a sua atuação e manutenção de abordagens pautadas em concepções tradicionalistas. A partir disso, reconhece-se a importância da abordagem educacional das translinguagens, apresentada pela pesquisadora Ofélia García, a qual rompe com as realidades estruturais da sala de aula e promove um contexto multilíngue que analisa o aluno a partir de uma perspectiva interna, valorizando o seu desempenho e repertório linguístico de forma completa e única. Ao cotejar esse campo, o questionamento da pesquisa surge com a finalidade de compreender como as práticas translíngues contribuem para o aspecto linguístico e para a produção de sentido no ensino bilíngue a partir de uma perspectiva dialógica. Embasa-se nos estudos teóricos de Bakhtin e o Círculo a partir de Brait (2006) para entender essa relação em suas dimensões extralinguísticas e em seu caráter social para o processo de aquisição de conhecimento e consequente produção de repertório. Como resultado, associam-se as práticas translíngues com a constituição de discursos diversificados e multilíngues.
Accounting conservatism, Islamic social reporting, and earning responses coefficient: An empirical analysis
Authors: Embuningtiyas Sandra Sukma , Anggraeni Rani , Puspasari Oktaviani Rita
Published: June 2023

This research aims to determine the influence of accounting conservatism, sharia-based social performance disclosure and company size both partially and simultaneously against earnings response (earnings response coefficient). Empirical study of Sub- sector property and Real Estate companies registered in ISSI on Indonesia Stock Exchange period 2015-2018. The method used is descriptive and verification method with quantitative data. The data collection technique used non-participating observation. The results concluded that partially accounting conservatism was positively and significantly influential on the earnings response, sharia-based social performance disclosure has a positive and significant effect on earnings response, company size positively and significantly affects the earnings response and the simultaneous conservatism of accounting, sharia-based social performance disclosure and company size together have a positive and significant impact on the earnings response.
Risk Factors to Predict Acute Respiratory Failure in Patients with Acute Pesticide Poisoning
Authors: Cho Nam-Jun , Park Samel , Lee Eun Young , Gil Hyo-Wook
Published: June 2023

Acute respiratory failure is an important risk factor for mortality in patients with acute pesticide poisoning. Therefore, it is necessary to investigate the risk factors to predict respiratory failure in these patients. This study retrospectively investigated the clinical features of respiratory failure among patients with acute pesticide poisoning requiring mechanical ventilation. This study included patients who were admitted with intentional poisoning by pesticide ingestion from January 2017 to December 2019. Paraquat intoxication was excluded. Among 469 patients with acute pesticide poisoning, 398 patients were enrolled in this study. The respiratory failure rate was 30.4%. The rate of respiratory failure according to the type of pesticide was carbamate (75.0%), organophosphate (52.6%), glufosinate (52.1%), glyphosate (23%), pyrethroid (8.9%), and others (17%). The mortality was 25.6% in the respiratory failure group. The risk factors for respiratory failure were old age, low body mass index, and ingestion of more than 300 mL. In conclusion, respiratory failure is a risk factor for mortality in pesticide poisoning. Old age, low body mass index, and ingestion of more than 300 mL are the risk factors for predicting respiratory failure.
Predicting Factors Associated with Large Amounts of Glyphosate Intoxication in the Early-Stage Emergency Department: QTc Interval Prolongation
Authors: Kyung Dong-Soo , Jeon Jae-Cheon , Choi Woo Ik , Lee Sang-Hun
Published: June 2023

Purpose: Taking large amounts of glyphosate is life-threatening, but the amounts of glyphosate taken by patients for suicide are not known precisely. The purpose of this study was to find the predictors of large amounts of glyphosate ingestion. Methods: This retrospective study analyzed patients presenting to an emergency department with glyphosate intoxication between 2010 and 2019, in a single tertiary hospital. The variables associated with the intake amounts were investigated. The parameters were analyzed by multivariate variate logistic regression analyses and the receiver operating characteristic (ROC) curve. Results: Of the 28 patients with glyphosate intoxication, 15 (53.6%) were in the large amounts group. Univariate analysis showed that metabolic acidosis, lactic acid, and corrected QT (QTc) interval were significant factors. In contrast, multivariate analysis presented the QTc interval as the only independent factor with intoxication from large amounts of glyphosate. (odds ratio, 95% confidence interval: 1.073, 1.011-1.139; p=0.020) The area under the ROC curve of the QTc interval was 0.838. Conclusion: The QTc interval is associated significantly with patients who visit the emergency department after being intoxicated by large amounts of glyphosate. These conclusions will help in the initial triage of patients with glyphosate intoxication.
QTc Prolongation due to Psychotropic Drugs Intoxication and Its Risk Assessment
Authors: Park Kwan Ho , Hong Hoon Pyo , Lee Jong Seok , Jeong Ki Young , Ko Seok Hun , Kim Sung Kyu , Choi Han Sung
Published: June 2023

Purpose: The aims of the present study were twofold. First, the research investigated the effect of an individual's risk factors and the prevalence of psychotropic drugs on QTc prolongation, TdP (torsades de pointes), and death. Second, the study compared the risk scoring systems (the Mayo Pro-QT risk score and the Tisadale risk score) on QTc prolongation. Methods: The medical records of intoxicated patients who visited the emergency department between March 2010 and February 2019 were reviewed retrospectively. Among 733 patients, the present study included 426 psychotropic drug-intoxicated patients. The patients were categorized according to the QTc value. The known risk factors of QTc prolongation were examined, and the Mayo Pro-QT risk score and the Tisadale risk score were calculated. The analysis was performed using multiple logistic regression, Spearman correlation, and ROC (receiver operating characteristic). Results: The numbers in the mild to moderate group (male: 470≤QTc<500 ms, female: 480≤QTc<500 ms) and severe group (QTc≥500 ms or increase of QTc at least 60ms from baseline, both sex) were 68 and 95, respectively. TdP did not occur, and the only cause of death was aspiration pneumonia. The statically significant risk factors were multidrug intoxications of TCA (tricyclic antidepressant), atypical antipsychotics, an atypical antidepressant, panic disorder, and hypokalemia. The Tisadale risk score was larger than the Mayo Pro-QT risk score. Conclusion: Multiple psychotropic drugs intoxication (TCA, an atypical antidepressant, and atypical antipsychotics), panic disorder, and hypokalemia have been proven to be the main risk factors of QTc prolongation, which require enhanced attention. The present study showed that the Tisadale score had a stronger correlation and predictive accuracy for QTc prolongation than the Mayo Pro-QT score. As a result, the Tisadale risk score is a crucial assessment tool for psychotropic drug-intoxicated patients in a clinical setting.
Ciguatera fish poisoning in Korea: a case report
Authors: Kang Jeong Ho , Lee Sung Kgun
Published: June 2023

Ciguatera is the commonest syndrome of marine poisoning that is caused by the ingestion of ciguatoxins that accumulate in certain tropical and subtropical finfish. It is endemic throughout the subtropical and tropical regions of the Indo-Pacific and Caribbean and has been rarely reported in Korea. With the expansion of travel, tourism, and the import of fish from the tropics, ciguatera poisoning now affects a diverse population. We report a case of ciguatera in a 70-year-old woman, presenting with general paralysis and coma, which developed after consuming codfish and mackerel in Korea.
The Significance of the Strong Ion Gap in Predicting Acute Kidney Injury and In-hospital Mortality in Critically Ill Patients with Acute Poisoning
Authors: Sim Tae Jin , Cho Jae Wan , Lee Mi Jin , Jung Haewon , Park Jungbae , Seo Kang Suk
Published: June 2023

Purpose: A high anion gap (AG) is known to be a significant risk factor for serious acid-base imbalances and death in acute poisoning cases. The strong ion difference (SID), or strong ion gap (SIG), has recently been used to predict in-hospital mortality or acute kidney injury (AKI) in patients with systemic inflammatory response syndrome. This study presents a comprehensive acid-base analysis in order to identify the predictive value of the SIG for disease severity in severe poisoning. Methods: A cross-sectional observational study was conducted on acute poisoning patients treated in the emergency intensive care unit (ICU) between December 2015 and November 2020. Initial serum electrolytes, base deficit (BD), AG, SIG, and laboratory parameters were concurrently measured upon hospital arrival and were subsequently used along with Stewart's approach to acid-base analysis to predict AKI development and in-hospital death. The area under the receiver operating characteristic curve (AUC) and logistic regression analysis were used as statistical tests. Results: Overall, 343 patients who were treated in the intensive care unit were enrolled. The initial levels of lactate, AG, and BD were significantly higher in the AKI group (n=62). Both effective SID [SIDe] (20.3 vs. 26.4 mEq/L, p<0.001) and SIG (20.2 vs. 16.5 mEq/L, p<0.001) were significantly higher in the AKI group; however, the AUC of serum SIDe was 0.842 (95% confidence interval [CI]=0.799-0.879). Serum SIDe had a higher predictive capacity for AKI than initial creatinine (AUC=0.796, 95% CI=0.749-0.837), BD (AUC=0.761, 95% CI=0.712-0.805), and AG (AUC=0.660, 95% CI=0.607-0.711). Multivariate logistic regression analyses revealed that diabetes, lactic acidosis, high SIG, and low SIDe were significant risk factors for in-hospital mortality. Conclusion: Initial SIDe and SIG were identified as useful predictors of AKI and in-hospital mortality in intoxicated patients who were critically ill. Further research is necessary to evaluate the physiological nature of the toxicant or unmeasured anions in such patients.
Comparison of medical history based diagnosis and urine test using ultra-performance liquid chromatography-tandem mass spectrometry in drug overdose
Authors: Lee Ja-Young , Cha Kyungman , Jeong Won Jung , Kim Hyung Min , So Byung Hak
Published: June 2023

Purpose: In patients with acute drug overdose, identification of drugs ingested is crucial to make a precise diagnosis. In most cases, the diagnoses are made on the medical history and physical examination findings. This study was undertaken to determine the concordance of diagnosis made on the basis of patient history by comparing it with urine toxicology analysis. Methods: This was a retrospective study of drug intoxicated patients over 18 years old who presented to the emergency center from 2017 to 2019. Specimens from urine were tested using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-TMS). The test results were compared with information obtained from patients. Diagnostic concordances for drug detection in intoxicated patients were calculated. Logistic regression analysis was used to examine the association between clinical characteristics and diagnostic discrepancy. Results: Totally, 370 patients were included in the analysis. Overall, 66 types of drugs were detected by UPLC-TMS. The drugs detected most frequently were zolpidem (104, 27.8%), citalopram (70, 18.7%), and paracetamol (66, 17.6%). The mean diagnostic concordance of patients was 52.7%. There were statistically significant diagnostic discrepancies in patients with underlying depression and patients intoxicated with multiple types of drugs. Conclusion: In ED patients with acute drug overdose, the diagnoses made on history alone were often inaccurate. It is essential to perform urine toxicology tests such as UPLC-TMS as a confirmatory instrument to improve accuracy in evaluating patients with drug intoxication.
Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) syndrome due to antidepressant
Authors: Nah Sangun , Kim Han Bit , Han Sangsoo , Choi Sungwoo , Lim Hoon
Published: June 2023

Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) syndrome is characterized by an altered mental status. The acute MRI lesions show abnormal restricted diffusion imaging bilaterally and symmetrically in the cerebellum, hippocampus, and basal nuclei. This syndrome is an unknown syndrome and is presumed to be mainly an opioidinduced toxidrome. Here, we present a case study wherein we show that it can also be caused by an antidepressant overdose.
CASP15 cryoEM protein and RNA targets: refinement and analysis using experimental maps
Authors: Topf Maya , Mulvaney Thomas , Kretsch Rachael C. , Elliott Luc , Beton Joe , Kryshtafovych Andriy , Rigden Daniel , Das Rhiju
Published: June 2023

CASP assessments primarily rely on comparing predicted coordinates with
experimental reference structures. However, errors in the reference
structures can potentially reduce the accuracy of the assessment. This
issue is particularly prominent in cryoEM-determined structures, and
therefore, in the assessment of CASP15 cryoEM targets, we directly
utilized density maps to evaluate the predictions. A method for ranking
the quality of protein chain predictions based on rigid fitting to
experimental density was found to correlate well with the CASP
assessment scores. Overall, the evaluation against the density map
indicated that the models are of high accuracy although local assessment
of predicted side chains in a 1.52 Å resolution map showed that
side-chains are sometimes poorly positioned. The top 136 predictions
associated with 9 protein target reference structures were selected for
refinement, in addition to the top 40 predictions for 11 RNA targets. To
this end, we have developed an automated hierarchical refinement
pipeline in cryoEM maps. For both proteins and RNA, the refinement of
CASP15 predictions resulted in structures that are close to the
reference target structure, including some regions with better fit to
the density. This refinement was successful despite large conformational
changes and secondary structure element movements often being required,
suggesting that predictions from CASP-assessed methods could serve as a
good starting point for building atomic models in cryoEM maps for both
proteins and RNA. Loop modeling continued to pose a challenge for
predictors with even short loops failing to be accurately modeled or
refined at times. The lack of consensus amongst models suggests that
modeling holds the potential for identifying more flexible regions
within the structure.
Antibiotic resistant biofilms and the quest for novel therapeutic strategies
Authors: SUREKHA SAUMYA , LAMIYAN ASHISH
Published: June 2023

Antimicrobial resistance (AMR) is one of the major leading causes of
death around the globe. Present treatment pipelines are insufficient to
overcome the critical situation. Prominent biofilm forming human
pathogens which have the ability to thrive in infection sites using
adaptive features results in biofilm persistence. This is a challenge
due to involvement of unknown pathways for which therapeutic targets are
still unknown. In regard to this developing newer and effective
treatment options using edge cutting technologies in medical research is
the need of time. The reasons underlying the adaptive features in
biofilm persistence have been centred on different metabolic and
physiological aspects. The high tolerance levels against antibiotics
direct researchers to search for novel bioactive molecules that can help
combat the problem. In view of this, the present review outlines the
focuses on a possible opportunity of different strategies which are in
testing pipeline can thus be developed into products ready to use.
Airway epithelial overexpressed CTSK induces airway remodeling through EMTU activation in asthma
Authors: Yao Ye , Qin Ling , Wang Weijie , Liu Jingjing , Qin Qingwu , Liu Huijun , Yuan Lin , Yuan Yunchang , Du Xizi , Wu Xinyu , Zhao Bingrong , Bei Qing , Huang Leng , Wang Gang , Yang Xiang , Qu Xiangpin , Zhang Xuewei , Yang Ming , Xia Zhenkun , liu Chi
Published: June 2023

Accumulating studies in recent years have revealed that airway
remodeling is involved in the occurrence, development, and treatment
sensitivity of asthma. Airway epithelial cells (AECs) regulate the
activation of epithelial-mesenchymal trophic units (EMTUs) during airway
remodeling through secretion of a series of signaling mediators.
However, the major trigger and the intrinsic pathogenesis of airway
remodeling is still obscure. Here, we show that the expression of CTSK
in airway epithelia increased significantly along with the development
of airway remodeling in HDM-stressed asthma model. Increased secretion
of CTSK from airway epithelia induced the activation of EMTU through the
activation of PAR2-mediated pathway. We found that CTSK is a potential
biomarker of airway remodeling for asthma patients that can reflect the
degree of airway remodeling and the severity of asthma. Blockade of CTSK
inhibits EMTU activation and alleviate airway remodeling effectively
that is an effective intervention target of airway remodeling. Thus, our
findings provide that CTSK is a potential biomarker for airway
remodeling which may also be a useful target for the targeted
intervention of airway remodeling in asthma patients.
HepaRG™ Cells as a New Approach Methodology Follow Up to a Positive Response in Human TK6 Cell Micronucleus Assay: Naphthalene Case Study
Authors: Recio Les , Fowler Jasmine , Martin Lincoln , Swartz Carol
Published: June 2023

We are evaluating the use of metabolically competent HepaRG™ cells
combined with CometChip for DNA damage and the micronucleus (MN) assay
as a follow up for in vitro positive genotoxic response as alternatives
to in vivo genotoxicity testing.. Naphthalene is genotoxic with rat
liver S9 in human TK6 cells inducing a nonlinear dose-response for the
induction of micronuclei in the presence of rat liver S9. To follow up
this response, we used metabolically competent HepaRG™ cells as a New
Approach Methodology (NAM) alternative to animals for genotoxicity
assessment of naphthalene. In HepaRG™ cells, naphthalene genotoxicity
was assessed using 12 concentrations of naphthalene with the top dose
used for assessment of genotoxicity of 1.7 mM corresponding to 45% cell
survival. In contrast to human TK6 cell with S9, Naphthalene was not
genotoxic in either the HepaRG™ MN Assay or the Comet Assay using
CometChip. The lack of genotoxicity in both the MN and comet assays in
HepaRG™ cells is likely due to Phase II enzymes removing phenols
preventing further bioactivation to quinones and efficient detoxication
of naphthalene quinones or epoxides by glutathione conjugation. In
contrast to CYP450 mediated metabolism, these Phase II enzymes are
inactive in rat liver S9 due to lack of appropriate cofactors causing a
positive genotoxic response. This data indicates that rat liver
S9-derived BMD10 over-predicts naphthalene genotoxicity BMD calculations
when compared to hepatocytes. Metabolically competent hepatocyte models
like HepaRG™ cells should be considered as human-relevant NAMs for use
genotoxicity assessments to reduce reliance on rodents.
Observation of Sediment Mobilization by an Internal Solibore on the California Inner Shelf
Authors: Jefferson Joseph Darryl , Simeonov Julian A , Calantoni Joseph , Sheremet Alex
Published: June 2023

Acoustic backscatter, velocimetry measurements of the nearbed velocity
profiles, and thermistor chain measurements of the temperature
stratification were used to understand the bottom boundary layer flows
and associated sediment transport processes in 35 meters water depth on
the California shelf off of Point Sal where the bottom sediment consist
of fine sand with median grain size diameter of $d_{50}=0.1$ mm.
The observations show that the nearbed flow is dominated by the bore of
a shoaling internal tide whose steepening front generated a series of
internal solitary waves (ISW) with a 15-min period superposed on the
tail of the bore. The bore-induced nearbed flow was strongly asymmetric
with 20 cm/s seaward directed flow under the bore trough that exceeded
the bottom stress threshold for mobilization of the 0.1 mm sand, and
5-10 cm/s onshore flow during the tail of the bore that produced only
subcritical bottom stress. The ISWs induced symmetric 5-10 cm/s nearbed
velocity which however combined with the bore tail to produce onshore
flows under the wave crests with bottom stress that also exceeded the
sediment mobilization threshold.
Impact of anthropogenic disturbance on nesting Chimney Swift (Chaetura pelagica) including best practices for conservation
Authors: Poole Timothy , Stewart Barbara , Stewart Robert
Published: June 2023

The effect of anthropogenic disturbance on nesting Chimney Swift (Chaetura pelagica) is poorly described. We review five case studies of anthropogenic disturbance around Chimney Swift nest sites caused by building construction, demolition, and maintenance activities in St. Adolphe, Manitoba. Chimney Swift behaviour and nest site activity did not appear to be overtly influenced by building demolition and construction conducted on adjacent buildings or lots within 13–30 m of nest chimneys. In contrast, Chimney Swift behaviour and breeding success appeared to be negatively affected by loud interior renovations and rooftop work conducted in or on the same building as the nest chimneys. The presence of humans on the roof of the nest building prevented Chimney Swifts from entering the nest site and reduced the overall rate of feeding young. Based on these observations, we provide conservation best practices for building construction and maintenance projects conducted within or on the same building as nest chimneys to help ensure protection of Chimney Swifts and their nesting habitat during the breeding season.
Red-eared Slider (Trachemys scripta elegans) nests in the Greater Toronto Area
Authors: Dupuis-Désormeaux Marc , Van Alstyne Grace , Mueller Maureen , Takayesu Ruth , D'Elia Vince , MacDonald Suzanne
Published: June 2023

Red-eared Slider (Trachemys scripta elegans) is a non-native turtle found in abundance in Toronto’s wetlands as a result of pet releases. Although this species is known to reproduce successfully in southwestern Ontario, Canada, there is yet no evidence to suggest successful reproduction in the Greater Toronto Area (GTA). As part of a native turtle nest protection program, volunteers inadvertently placed nest protector boxes over four slider nests in 2021 and 10 nests in 2022. This gave us the opportunity to determine whether nests produced viable offspring and whether these hatchlings would emerge in the fall. The exact nesting date for each nest was recorded. In 2021, eight of the 41 eggs from the slider nests showed very late-stage arrested embryonic development. In 2022, one of the nests had four hatchlings out of their eggshells but still inside the nest cavity. It is unclear whether the hatchlings would emerge later in the fall or overwinter in the nest cavity and emerge the following spring. If the small population sampled accurately reflects what occurs in the GTA, complete egg development may be possible for this species in some years, in some locations, with the right local micro-climate and micro-habitat. We discuss implications for turtle nest protection in Toronto.
Training as a Vital Safety Intervention Activity for Employees’ Job Commitment: A Case Study of Steel Factory
Authors: Ajayeoba A. O. , Fajob i M. O. , Raheem W. A , Adebiyi K. A. , Okuma S. O. , Fatukasi S. , Ajayeoba A. S.
Published: June 2023

The need for human resources, otherwise referred to as employees, in the effective running of any establishment cannot be over-emphasized, especially in steel factories. Likewise, the effect of training as one of the vital safety intervention activities on accident rate reduction is highly imperative. Thus, its effect on the rate of employees' commitment to the job is understudied. Therefore, this study investigated the effect of training as one of the key safety intervention activities on the employees' commitment to the job. This study adopted the participatory approach, and the stakeholders, who are 67 employees of the steel factory, were considered for questionnaire administration and interview. This study sought information on the respondents' demographic characteristics, activities carried out, safety management, and influence on job commitments. Data collected were statistically analyzed using the SPSS 20.0 version. The respondents' ages are normally distributed around 26 – 35 and 36 – 45 age brackets, with 56.72 and 31.34 %, respectively. The majority (36 %) of this factory’s employees were in the manufacturing and melting unit, while the least (16 %) were in the packaging unit. The following percent, 7.46 and 44.78 %, strongly agreed and agreed to the management's provision of safety induction and training, while only 37.31 % disagreed. The study established that training intervention has a positive influence on the job commitment of factory employees. Thus, about 93% of the workers believed that safety training should be given priority over PPE or incentive/motivation. Keywords: Safety Management, Job Commitment, Factory Employees, Influence, Steel. Aims Research Journal Reference Format: Ajayeoba A. O., Fajobi M. O., Raheem W. A., Adebiyi K. A., Okuma S. O., Fatukasi S. O. & Ajayeoba, A.S. (2022): Training as a Vital Safety Intervention Activity for Employees’ Job Commitment. Advances in Multidisciplinary and Scientific Research. Vol. 9. No. 1, Pp 37-50. www.isteams.net/aimsjournal. dx.doi.org/10.22624/AIMS/V9N1P3x
Approximation properties of Bernstein-Stancu operators preserving e−2x
Authors: Usta Fuat , Mursaleen Mohammad , Çakır İbrahim
Published: June 2023

Bernstein-Stancu operators are one of the most powerful tool that can be used in approximation theory. In this manuscript, we propose a new construction of Bernstein-Stancu operators which preserve the constant and e?2x, x > 0. In this direction, the approximation properties of this newly defined operators have been examined in the sense of different function spaces. In addition to these, we present the Voronovskaya type theorem for this operators. At the end, we provide two computational examples to demonstrate that the new operator is an approximation procedure.