bluuebunny/crossref_metadata_2025 huggingface dataset:
Prescription pattern and effectiveness of antihypertensive drugs in patients with aortic dissection who underwent surgery
Authors: Liao Kuang-Ming , Shen Chuan-Wei , Huang Yun-Hui , Lu Chun-Hui , Lai Hsuan-Lin , Chen Chung-Yu
Published: November 2023

Background: Surgical patients with aortic dissection often require multiple antihypertensive drugs to control blood pressure. However, the prescription pattern and effectiveness of antihypertensive drugs for these patients are unclear. We aimed to investigate the prescription pattern and effectiveness of different classes of antihypertensive drugs in surgical patients with aortic dissection.

Methods: Newly diagnosed aortic dissection patients who underwent surgery, aged >20 years, from 1 January 2012 to 31 December 2017 were identified. Patients with missing data, in-hospital mortality, aortic aneurysms, or congenital connective tissue disorders, such as Marfan syndrome, were excluded. Prescription patterns of antihypertensive drugs were identified from medical records of outpatient visits within 90 days after discharge. Antihypertensive drugs were classified into four classes: 1) β-blockers, 2) calcium channel blockers (CCBs), 3) renin–angiotensin system, and 4) other antihypertensive drugs. Patients were classified according to the number of classes of antihypertensive drugs as follows: 1) class 0, no exposure to antihypertensive drugs; 2) class 1, antihypertensive drugs of the same class; 3) class 2, antihypertensive drugs of two classes; 4) class 3, antihypertensive drugs of three classes; or 5) class 4, antihypertensive drugs of four classes. The primary composite outcomes included rehospitalization associated with aortic dissection, death due to aortic dissection, and all-cause mortality.

Results: Most patients were prescribed two (28.87%) or three classes (28.01%) of antihypertensive drugs. In class 1, β-blockers were most commonly used (8.79%), followed by CCBs (5.95%). In class 2, β-blockers+CCB (10.66%) and CCB+RAS (5.18%) were the most common drug combinations. In class 3, β-blockers + CCB+RAS (14.84%) was the most prescribed combination. Class 0 had a significantly higher hazard of the composite outcome (HR, 2.1; CI, 1.46–3.02; p < 0.001) and all-cause mortality (HR, 2.34; CI, 1.56–3.51; p < 0.001) than class 1. There were no significant differences in hazards for rehospitalization associated with aortic dissection among classes.

Conclusion: Among operated patients with type A aortic dissection, no specific type of antihypertensive drug was associated with a better outcome, whereas among those with type B aortic dissection, the use of β-blockers and CCBs was related to a significantly lower risk of the composite outcome.
Overview of DISCOVER22 experiment in the framework of INFN-LNGS Cosmic Silence activity: challenges and improvements in underground radiobiology
Authors: Morciano Patrizia , Dini Valentina , Berardinelli Francesco , Baiocco Giorgio , Conte Valeria , Udroiu Ion , Barbato Federica , Marinaccio Jessica , Anello Pasqualino , Antoccia Antonio , Tabocchini Maria Antonella , Selva Anna , Canella Stefania , Bianchi Anna , Guardamagna Isabella , Lonati Leonardo , Scifoni Emanuele , Laubenstein Matthias , Balata Marco , Ferella Francesco , Grifoni Daniela , Galante Angelo , Maccarrone Mauro , Tirelli Valentina , Grasso Felicia , Sanchez Massimo , Sgura Antonella
Published: November 2023

One of the most intriguing and still pending questions in radiobiology is to understand whether and how natural environmental background radiation has shaped Life over millions of years of evolution on Earth. Deep Underground Laboratories (DULs) represent the ideal below-background exposure facilities where to address such a question. Among the few worldwide DULs, INFN-Laboratorio Nazionale del Gran Sasso (LNGS) is one of the largest in terms of size and infrastructure. Designed and built to host neutrino and dark matter experiments, since the 1990 s the LNGS has been one of the first DULs to systematically host radiobiology experiments. Here we present the DISCOVER22 (DNA Damage and Immune System Cooperation in VEry low Radiation environment 2022) experiment recently started at LNGS. DISCOVER22 aims at investigating how the low radiation background modulates the Immune System (IS) response in in vitro and in vivo models. Underground radiobiology experiments are particularly complex and tricky to design and perform. In these studies, the accurate characterization of exposure scenarios is mandatory, but a challenging aspect is to understand how the very few ionizing tracks in the ultra-Low Radiation Environment (LRE) interact with the living matter in space and time in order to trigger different biological responses. In this Perspective, we describe these challenges and how we address them through a microdosimetric and a radiobiological approaches. We aim at linking physical microdosimetric measurements and the corresponding biological radiation responses by using radiation biophysical models that could shed light on many as yet unresolved questions.
Game-theoretic approach to understanding status transition dynamics and employee performance enhancement in organizations
Authors: Wu Mengyun , Zhu Yuqing , Yang Ting , Xu Yifan
Published: November 2023

To foster high-quality economic development, it is critical to not only enhance the “hard environment,” such as infrastructure, but also to make significant strides in the “soft environment,” such as the relationship between government and businesses. This study posits that the government, industry associations, and enterprises should collectively participate in fostering a “cordial and clean” government-business relationship. By resolving the equilibrium solution of the three-party game, it has been identified that achieving the goal of constructing a cordial and clean government-business relationship and aligning with the ambitions of enterprises necessitates policy guidance and a balance of interests among the government, industry associations, and enterprises. The research also contributes to the beneficial exploration of game theory, by constructing a network model from the perspective of public management and integrating it with the practice of local administrative reform. This integration is particularly relevant for industry associations, and their systematic analysis further enhances the practical applicability of the research.
Application of electrogastrogram in assessment of gastric motility in acute pancreatitis
Authors: Cai Ying , Wang Jinyun , Huang Deqiang , Luo Lingyu
Published: November 2023

Background: Electrogastrogram (EGG) can reflect gastric motility disorders in many diseases, but its application in acute pancreatitis (AP) has not been studied. Therefore, our study aimed to investigate the value of EGG in assessing the existence of gastric motility disorder in patients with AP and in predicting the severity of AP.

Methods: Patients with AP admitted to the First Affiliated Hospital of Nanchang University from June 2020 to December 2020 were enrolled. Five EGG parameters (Percentage of normal gastric slow wave (PNGSW), main frequency, average frequency, percentage of gastric tachycardia (PGT), percentage of gastric bradycardia (PGB)) were collected. The receiver operating characteristic (ROC) curve was constructed to judge the predictive value of EGG parameters to AP severity.

Results: The PNGSW in AP patients was significantly lower than that of the control group (p < 0.05), and the PGB was higher in AP patients than that of the control group (p < 0.05). The area under curve (AUC) of the PNGSW and the PGB in diagnosing non-mild acute pancreatitis (N-MAP) were 0.777 (95% CI: 0.676-0.877, p < 0.001) and 0.775 (95% CI: 0.670-0.879, p < 0.001) respectively. After combining with C-reactive protein, the accuracy, sensitivity and specificity of predicting N-MAP were improved.

Conclusion: EGG parameters can well reflect the gastric motility disorder of AP patients. The PNGSW and the PGB can be used to predict the occurrence of N-MAP.
Characterization of gene expression patterns in response to an orthotospovirus infection between two diploid peanut species and their hybrid
Authors: Chen Yi-Ju , Catto Michael A. , Pandey Sudeep , Leal-Bertioli Soraya , Abney Mark , Hunt Brendan G. , Bag Sudeep , Culbreath Albert , Srinivasan Rajagopalbabu
Published: November 2023

Tomato spotted wilt orthotospovirus (TSWV) transmitted by thrips causes significant yield loss in peanut (Arachis hypogaea L.) production. Use of peanut cultivars with moderate field resistance has been critical for TSWV management. However, current TSWV resistance is often not adequate, and the availability of sources of tetraploid resistance to TSWV is very limited. Allotetraploids derived by crossing wild diploid species could help introgress alleles that confer TSWV resistance into cultivated peanut. Thrips-mediated TSWV screening identified two diploids and their allotetraploid possessing the AA, BB, and AABB genomes Arachis stenosperma V10309, Arachis valida GK30011, and [A. stenosperma × A. valida]4x (ValSten1), respectively. These genotypes had reduced TSWV infection and accumulation in comparison with peanut of pure cultivated pedigree. Transcriptomes from TSWV-infected and non-infected samples from A. stenosperma, A. valida, and ValSten1 were assembled, and differentially expressed genes (DEGs) following TSWV infection were assessed. There were 3,196, 8,380, and 1,312 significant DEGs in A. stenosperma, A. valida, and ValSten1, respectively. A higher proportion of genes decreased in expression following TSWV infection for A. stenosperma and ValSten1, whereas a higher proportion of genes increased in expression following infection in A. valida. The number of DEGs previously annotated as defense-related in relation to abiotic and biotic stress was highest in A. valida followed by ValSten1 and A. stenosperma. Plant phytohormone and photosynthesis genes also were differentially expressed in greater numbers in A. valida followed by ValSten1 and A. stenosperma, with over half of those exhibiting decreases in expression.
Prevalence and spatial distribution of cranberry fruit rot pathogens in British Columbia, Canada and potential fungicides for fruit rot management
Authors: Wood Brandon , McBride Ethan , Nabetani Keiko , Griffin Taylor , Sabaratnam Siva
Published: November 2023

Twenty-eight cranberry farms in southwestern British Columbia were investigated for the prevalence and spatial distribution of fungal pathogens that contribute to fruit rot incidence. Farms were selected from six regions where most cranberry production is concentrated. Flowers, and green and ripe fruit (var. ‘Stevens’) samples, collected during two consecutive crop seasons, were analyzed for fruit rot pathogens. The most frequently isolated pathogens were identified as Allantophomopsis cytisporea, Botrytis cinerea, Coleophoma empetri, Colletotrichum fioriniae, Colletotrichum gloeosporioides, Fusicoccum putrefaciens, Glomerella sp., Phomopsis vaccinii, Phyllosticta elongata, Phyllosticta vaccinii and Physalospora vaccinii. The pathogens Allantophomopsis cytisporea, Phyllosticta spp., and Physalospora vaccinii were found at high incidence. These pathogens were present in all cranberry growing regions, although their mean percentage incidence varied from farm-to-farm and region-to-region. Amongst the pathogens from three phenological stages of cranberry crop examined, ripe fruit had the highest percentage incidence of fruit rot pathogens compared to that of flowers or green fruit; thus, indicating their presence at the early stages of crop development. The efficacy to inhibit the mycelial growth and spore germination of the fruit rot pathogens by twenty six fungicides, belonging to nine different modes of actions, were evaluated in vitro. The copper-based fungicides and captan of group M, flutriafol, triforine, difenoconazole, prothioconazole and propiconazole of group 3, benzovindiflupyr of group 7, and fosetyl-Al of group 33 demonstrated a high degree of efficacy in inhibiting the mycelial growth of all fruit rot pathogens. The fungicides chlorothalonil of group M, fenbuconazole of group 3, pyrimethanil and cyprodinil of group 9, and fludioxonil of group 12 also demonstrated activity against most fruit rot pathogens. The copper-based fungicides, chlorothalonil, captan, flutriafol, triforine, difenoconazole, prothioconazole, propiconazole, benzovindiflupyr, and fosetyl-Al effectively prevented the spore germination of most fruit rot pathogens. This demonstrated activity of the fungicides towards cranberry fruit rot pathogens should be assessed for efficacy in planta under field conditions. The current study identified the most critical fungal pathogens causing fruit rot of cranberry in British Columbia and potential fungicides that could be used in the management of fruit rot and to improve fruit quality and yield.
From flower to fruit: fruit growth and development in olive (Olea europaea L.)—a review
Authors: Rosati Adolfo , Lodolini Enrico Maria , Famiani Franco
Published: November 2023

The olive (Olea europaea L.) is the most cultivated tree crop in the Mediterranean and among the most cultivated tree crops worldwide. Olive yield is obtained by the product of fruit number and fruit size; therefore, understanding fruit development, in terms of both number and size, is commercially and scientifically relevant. This article reviews the literature on fruit development, from the flower to the mature fruit, considering factors that affect both fruit size and number. The review focuses on olive but includes literature on other species when relevant. The review brings the different factors affecting different phases of fruit development, addressed separately in the literature, under a single frame of interpretation. It is concluded that the different mechanisms regulating the different phases of fruit development, from pistil abortion to fruit set and fruit size, can be considered as different aspects of the same overall strategy, that is, adjusting fruit load to the available resources while striving to achieve the genetically determined fruit size target and the male and female fitness targets.
Integrating the technology acceptance model for social media-based learning with authentic leadership development: symmetric and asymmetric modeling
Authors: Asghar Muhammad Zaheer , Rasool Samma Faiz , Seitamaa-Hakkarainen Pirita , Arif Seema , Bano Sumaira
Published: November 2023

Introduction

The growing trend of social media use has influenced all segments of society, including education, during the COVID-19 pandemic. At the same time, authentic leadership is an emerging concept in positive psychology for dealing with emergencies in the digital era. The possibility of a relationship between the two was checked in preservice teachers studying in a teacher education department of a university in Pakistan. The conceptual framework of the study was built around teaching acceptance model (TAM) and Authentic leadership theory.

Methods

The survey method suited the aim of the research, and questionnaires aided us in gathering participant self-reporting responses. We conducted two surveys, and in between them, a course was taught online using social media as a teaching and learning platform. The survey results checked preservice teachers’ positive intentions toward social media-based learning, and the post-course survey studied the development of Authentic leadership attributes among the preservice teachers. Technology acceptance was measured across three constructs: ease of use, usefulness, and positive intentions. The results also reported the development of three authentic leadership characteristics: ethics, self-regulation, and self-awareness.

Results and discussion

This study is among the pioneering studies integrating TAM (i.e., the acceptance of social media-based learning) with leadership theory (i.e., authentic leadership). It also adds a methodological contribution by combining symmetrical (i.e., partial least squares structural equation modeling) and asymmetrical (i.e., fuzzy set qualitative comparative technique) for data analysis. The study’s findings are valuable for teacher education institutions, as they help prepare future teachers to become authentic leaders capable of addressing future crises by leveraging education through social media-based teaching and learning platforms.
Social networks and aggressive attitudes: who is who. Scoping review of the scientific production on their relationships
Authors: Martín-Martín Margarita , Bueno-Álvarez José Antonio
Published: November 2023

Introduction

In the current world, an increasing number of people use social networks as a scenario for socialization, which have come to stay as a part of human development. During this socialization process, violent situations occur all too often, despite their virtuality, and seriously compromises the emotional well-being of the other participants. Based on the work conducted on this subject, the following systematic review aims to establish the state of the art regarding the relationship between moral disengagement, disruptive behavior and emotional intelligence of social network users.

Method

A scoping review is carried out, according to the PRISMA-ScR criteria, consulting the WoS, Scopus, Education database, PsycINFO, PsycARTICLES, PLOS one and ScienceDirect databases, from 2021 up to the present day.

Results

A total of 999 articles related to the research topic were collected, although the result of research responding to the specific search criteria was reduced to 10.

Discussion

The research identified shows that there is a relationship between the level of moral development of social network users and their participation in aggressive online behavior. However, more research is needed, as it has not been demonstrated whether it is the networks that develop or favor the emergence of these attitudes, or simply act as facilitators for their amplified expression.
Lower cortical thickness and increased brain aging in adults with cocaine use disorder
Authors: Schinz David , Schmitz-Koep Benita , Tahedl Marlene , Teckenberg Timo , Schultz Vivian , Schulz Julia , Zimmer Claus , Sorg Christian , Gaser Christian , Hedderich Dennis M.
Published: November 2023

Background

Cocaine use disorder (CUD) is a global health issue with severe behavioral and cognitive sequelae. While previous evidence suggests a variety of structural and age-related brain changes in CUD, the impact on both, cortical thickness and brain age measures remains unclear.

Methods

Derived from a publicly available data set (SUDMEX_CONN), 74 CUD patients and 62 matched healthy controls underwent brain MRI and behavioral-clinical assessment. We determined cortical thickness by surface-based morphometry using CAT12 and Brain Age Gap Estimate (BrainAGE) via relevance vector regression. Associations between structural brain changes and behavioral-clinical variables of patients with CUD were investigated by correlation analyses.

Results

We found significantly lower cortical thickness in bilateral prefrontal cortices, posterior cingulate cortices, and the temporoparietal junction and significantly increased BrainAGE in patients with CUD [mean (SD) = 1.97 (±3.53)] compared to healthy controls (p < 0.001, Cohen’s d = 0.58). Increased BrainAGE was associated with longer cocaine abuse duration.

Conclusion

Results demonstrate structural brain abnormalities in CUD, particularly lower cortical thickness in association cortices and dose-dependent, increased brain age.
Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders
Authors: Michalski Christina , Wen Zhexing
Published: November 2023

Communication between the immune and the nervous system is essential for human brain development and homeostasis. Disruption of this intricately regulated crosstalk can lead to neurodevelopmental, psychiatric, or neurodegenerative disorders. While animal models have been essential in characterizing the role of neuroimmunity in development and disease, they come with inherent limitations due to species specific differences, particularly with regard to microglia, the major subset of brain resident immune cells. The advent of induced pluripotent stem cell (iPSC) technology now allows the development of clinically relevant models of the central nervous system that adequately reflect human genetic architecture. This article will review recent publications that have leveraged iPSC technology to assess neuro-immune interactions. First, we will discuss the role of environmental stressors such as neurotropic viruses or pro-inflammatory cytokines on neuronal and glial function. Next, we will review how iPSC models can be used to study genetic risk factors in neurological and psychiatric disorders. Lastly, we will evaluate current challenges and future potential for iPSC models in the field of neuroimmunity.
Accurate low-dose exposure assessment of benzene and monoaromatic compounds by diffusive sampling: sampling and analytical method validation according to ISO 23320 for radiello® samplers packed with activated charcoal
Authors: Zaratin Laura , Boaretto Caterina , Schianca Riccardo Carnevale , Hinkal George , Grignani Elena , Cottica Danilo
Published: November 2023

The research study aimed at providing an accurate low-dose benzene exposure assessment method, by validating diffusive monitoring techniques for benzene personal exposure measurements at workplaces where benzene concentrations are expected in the low ppb range, such as in the present-day chemical, petrochemical, foundry, and pharmaceutical industry. The project was aimed at addressing the need for a robust and fully validated method to perform personal exposure measurements considering that the occupational exposure limit value for benzene is going to be significantly lowered in the next few years. Diffusive sampling offers a reliable alternative to pumped sampling methods, intrinsic safety in potentially explosive atmospheres, lightness, and ease of use. In this study, the radiello® diffusive sampler, with the packed activated charcoal RAD130 adsorbing substrate [suitable for solvent desorption and analysis by high-resolution gas chromatography-flame ionization detection (HRGC-FID)], was used. The experiments have been conducted following the ISO 23320 standard in the range from 0.005 to 0.1 ppm (16 to 320 μg/m3), yielding a full validation of the sampling and analytical method. The sampler performances have fulfilled all requisites of the ISO 23320 standard, in particular: bias due to the selection of a non-ideal sorbent is lower than 10% (no significant back diffusion of benzene due to concentration change in the atmosphere); bias due to storage of samples for up to 2 months is lower than 10%; nominal uptake rate for benzene on RAD130 is 74.65 mL/min; and expanded uncertainty of the sampling and analytical method is 20.6%. The sampling and analytical method is therefore fit-for-purpose for the personal exposure measurements aimed at testing compliance with occupational exposure limit values for benzene. The method is also fit for short-duration exposure monitoring related to specific tasks, and other volatile organic compounds, usually found in the same workplaces, such as aliphatic and aromatic hydrocarbons and some oxygenated compounds, have also been studied. In particular, n-hexane and isopropyl benzene, whose classification is currently under revision, can be efficiently monitored by this technique.
Sustainment of the TeleSleep program for rural veterans
Authors: Belkora Jeffrey K. , Ortiz DeBoque Linda , Folmer Robert L. , Totten Annette M. , Williams Katherine , Whooley Mary A. , Boudreau Eilis , Atwood Charles W. , Zeidler Michelle , Rezayat Talayeh , Chilakamarri Priyanka , Sarmiento Kathleen F.
Published: November 2023

Background

In fiscal year 2021, the Veterans Health Administration (VHA) provided care for sleep disorders to 599,966 Veterans, including 189,932 rural Veterans. To further improve rural access, the VA Office of Rural Health developed the TeleSleep Enterprise-Wide Initiative (EWI). TeleSleep's telemedicine strategies include tests for sleep apnea at the Veteran's home rather than in a sleep lab; Clinical Video Telehealth applications; and other forms of virtual care. In 2017 and 2020, VHA provided 3-year start-up funding to launch new TeleSleep programs at rural-serving VA medical facilities.

Methods

In early 2022, we surveyed leaders of 24 sites that received TeleSleep funding to identify successes, failures, facilitators, and barriers relevant to sustaining TeleSleep implementations upon expiration of startup funding. We tabulated frequencies on the multiple choice questions in the survey, and, using the survey's critical incident framework, summarized the responses to open-ended questions. TeleSleep program leaders discussed the responses and synthesized recommendations for improvement.

Results

18 sites reported sustainment, while six were “on track.” Sustainment involved medical centers or regional entities incorporating TeleSleep into their budgets. Facilitators included: demonstrating value; aligning with local priorities; and collaborating with spoke sites serving rural Veterans. Barriers included: misalignment with local priorities; and hiring delays. COVID was a facilitator, as it stimulated adoption of telehealth practices; and also a barrier, as it consumed attention and resources. Recommendations included: longer startup funding; dedicated funding for human resources to accelerate hiring; funders communicating with local facility leaders regarding how TeleSleep aligns with organizational priorities; hiring into job classifications aligned with market pay; and obtaining, from finance departments, projections and outcomes for the return on investment in TeleSleep.
What's trust got to do with research: why not accountability?
Authors: Foláyan Morẹ́nikẹ́ Oluwátóyìn , Haire Bridget
Published: November 2023

This paper explores the intricate dynamics of trust, power, and vulnerability in the relationship between researchers and study participants/communities in the field of bioethics. The power and knowledge imbalances between researchers and participants create a structural vulnerability for the latter. While trust-building is important between researchers and study participants/communities, the consenting process can be challenging, often burdening participants with power abrogation. Trust can be breached. The paper highlights the contractual nature of the research relationship and argues that trust alone cannot prevent exploitation as power imbalances and vulnerabilities persist. To protect participants, bioethics guidance documents promote accountability and ethical compliance. These documents uphold fairness in the researcher-participant relationship and safeguard the interests of socially vulnerable participants. The paper also highlights the role of shared decision-making and inclusive deliberation with diverse stakeholders and recommends that efforts should be made by researchers to clarify roles and responsibilities, while research regulatory agents should transform the research-participant relationship into a legal-based contract governed by accountability principles. While trust remains important, alternative mechanisms may be needed to ensure ethical research practices and protect the interests of participants and communities. Striking a balance between trust and accountability is crucial in this regard.
The association between flagellin producers in the gut microbiota and HDL-C level in humans
Authors: Yiu Jensen H. C. , Cai Jieling , Cheung Samson W. M. , Chin Karie Tsz-Ching , Chan Chi Fai , Ma Edward S.C. , Sharma Rakesh , Dorweiler Bernhard , Woo Connie W.
Published: November 2023

The gut microbiota can be beneficial and harmful to cardiovascular health depending on the mechanisms. The interaction between gut microbiota-derived flagellin and toll-like receptor 5 in hepatocytes, resulting in apolipoprotein A1 (ApoA1) production, brings forth a cardiovascular benefit to the host. Here, the association between flagellated microbiota and high-density lipoprotein-cholesterol (HDL-C) in humans was explored. Through sex-based gut microbiota analysis of two population-based cohorts, the 500 Functional Genomics Project (500FG) and Chinese cohorts, we found positive correlations between the capacity to produce flagellins in the gut microbiota and HDL-C in females of the 500FG and males of Chinese cohorts. Eubacterium rectale, Lachnospira pectinoschiza, Roseburia intestinalis and Roseburia inulinivorans were crucial species for such correlations. Diverse types of flagellins and TLR5, but not NAIP/NLRC4, flagellin-engaging receptors, were detectable by proteomic analysis of the human liver. However, not all flagellated bacteria yield the same degree of such benefit because of differences in the penetration of flagellins where other factors such as geographics and diets may play important roles.
Carboxylated cellulose nanocrystal cryogel monoliths: a multi-tool study of morphology and porosity of pure and magnetite nanoparticle-decorated CNC scaffolds
Authors: Chen Xining , Andrews Mark P.
Published: November 2023

Tissue scaffolds are known to benefit from incorporation of nanoscale bio-additives like cellulose nanocrystals (CNC), which can affect porosity as an important tunable design parameter for bio-based scaffolds. In this paper, we probe how freeze-casting of carboxylated cellulose nanocrystals and CNC derivatized with magnetite nanoparticles yields macroscale cryogel scaffold monoliths. Cryogel topographical features and macropore morphologies depend on the conditions under which ice formation takes place, and on exposure to static magnetic fields. We examine porosity over several length scales with scanning electron microscopy (SEM) coupled with Local Thickness Euclidean distance image processing, small angle X-ray scattering (SAXS), and dynamic vapor sorption (DVS). SAXS data fitted with a mass fractal model and power law suggest that CNC particles aggregate to form well-defined compact walls in the range of 96.7–27.3 nm for all samples, while inclusion of Fe3O4 nanoparticles disrupts this compactness in the range of 27.3–4.8 nm. Analysis of DVS reveals that nanoparticles directly impact water uptake by the cryogel scaffolds and can reduce water sorption in mesopores with a radius of 5–6 nm.
Effects of the evolving early Moon and Earth magnetospheres
Authors: Green James , Boardsen Scott , Dong Chuanfei
Published: November 2023

Recently it has been identified that our Moon had an extensive magnetosphere for several hundred million years soon after it was formed when the Moon was within 20 Earth Radii (RE) from the Earth. Some aspects of the interaction between the early Earth-Moon magnetospheres are investigated by mapping the interconnected field lines between the Earth and the Moon and investigating how the early lunar magnetosphere affects the magnetospheric dynamics within the coupled magnetospheres over time. So long as the magnetosphere of the Moon remains strong as it moves away from the Earth in the antialigned dipole configuration, the extent of the Earth’s open field lines decreases. As a result, at times it significantly changes the structure of the field-aligned current system, pushing the polar cusp significantly northward, and forcing magnetotail reconnection sites into the deeper tail region. In addition, the combined magnetospheres of the Earth and the Moon greatly extend the number of closed field lines enabling a much larger plasmasphere to exist and connecting the lunar polar cap with closed field lines to the Earth. That configuration supports the transfer of plasma between the Earth and the Moon potentially creating a time capsule of the evolution of volatiles with depth. This paper only touches on the evolution of the early Earth and Moon magnetospheres, which has been a largely neglected space physics problem and has great potential for complex follow-on studies using more advanced tools and due to the expected new lunar data coming in the next decade through the Artemis Program.
Pilot study of a digital literacy-based intervention to confront concomitant crises amongst key food system actors in Chile
Authors: Kanter Rebecca , Boza Sofía , Acuña-Salazar Paula
Published: November 2023

Introduction

The fragility of food systems in Chile has been exposed through concomitant crises, from a social crisis in 2019 to the COVID-19 pandemic, and ongoing climate change. There is an increased dependence on information and communication technologies (ICTs) to produce, sell, and consume food and the digital divide has increased. The lack of digital literacy in Chile has not been evaluated or considered within comprehensive interventions.

Methods

To examine how local food systems can be strengthened, we conducted a pilot study of a digital literacy-based intervention with smallholder farmers, vendors, and consumers (n = 96) of different age groups (25–45 y, and 46–65 y) from adjacent urban and rural regions in Chile. Telephone surveys were carried out on the use of ICTs, access to the food environment, and agricultural practices during crises. A 5-week digital literacy intervention was carried out on digital confidence, the use of ICTs to generate networks, networks, the use of apps to sell or buy food, banking operations, and communication with state agencies. We also planned a virtual conversation about the food system and nutrition in Chile.

Results

All participants knew how to read and send WhatsApp messages but >50% of farmers and vendors reported cell signal problems. Between the 2019 social crisis and the COVID-19 pandemic, supermarkets as the main source of food decreased from 79 to 57%, and delivery increased from 2 to 17%. In total, 92% of the participants received the intervention, and 52% expressed satisfaction. Across participants, the average implementation score was 61%. Only one person connected to the virtual conversation.

Discussion

Crises have impacted how the Chilean population in both urban and rural regions navigate their food environment for their household as well as small-scale agricultural production in these areas; elucidating a greater dependency on ICTs amongst small-scale farmers, vendors, and consumers in Chile to buy and/or sell food. We also conclude that it is feasible to implement a digital literacy intervention for key food system actors in urban and rural settings in Chile. Future studies will contribute to the evidence base about the feasibility and impact of similar digital literacy interventions; an area of increasing importance given the rising prevalence of the digital food environment worldwide.
Assessment of in vitro efficacy for common surface disinfectants and antiseptics against Tritrichomonas foetus trophozoites
Authors: Martin Katy A. , Kovach Kristofer , Moscoso Erica , Carreiro Elizabeth , Jesudoss Chelladurai Jeba R. J. , Brewer Matthew T.
Published: November 2023

The protozoanTritrichomonas foetuscauses early embryonic death in cattle, there are no legal options for treating this parasite in the United States, and there are few developed protocols for cleaning veterinary and obstetrical equipment that may have been contaminated with trophozoites. In this study, we evaluated bleach, ethanol, acetic acid, chlorhexidine gluconate, and hydrogen peroxide solutions for the ability to kill trophozoitesin vitro. Our findings suggested that ethanol and bleach could adequately disinfect tools and equipment. Acetic acid, chlorhexidine, and hydrogen peroxide had applications as surface disinfectants in addition to potential as local topical treatments due to their past uses in veterinary theriogenology. Chlorhexidine gluconate demonstrated trophocidal effects by damaging parasite cell membranes and had the lowest effective concentration 50 (EC50) of any compound tested and was in the micromolar range. These findings, in conjunction with accepted clinical uses of chlorhexidine gluconate suggest that this is a convenient agent for disinfecting equipment. In addition, topical use of chlorhexidine is relatively common, setting the stage for further investigation of this compound as a topical therapeutic option for bovine trichomonosis.
Long-Term Survival of Investments Implemented under Endogenous Rural Development Programs: The Case Study of La Vera Region (Extremadura, Spain)
Authors: Castellano-Álvarez Francisco Javier , Robina-Ramírez Rafael
Published: November 2023

One of the main objectives of rural development programs is the economic diversification of rural areas. In the context of the European Union, the application of the Leader Initiative (referred to today as the Leader Approach) is perhaps the best example of this type of policy. Based on the case study methodology, the objective of this work is to analyze the viability of the projects promoted by this type of program. A long-term scenario is taken as a reference, and this is precisely one of the main methodological innovations of this research in relation to most of the analyses focused on the impacts of rural development programs. The results of the research show (a) an orientation of the development strategy towards the promotion of rural tourism and (b) differences in the survival of the projects according to the type of productive measure under which they have been implemented: agricultural valorization and marketing projects offer better results than those promoting rural tourism or the promotion of SMEs and crafts and services. These results call into question the notable concentration of investment in projects aimed at creating tourist accommodation.
Are Proteins Such as MMP2, IGF1, IL-13, and IL-1ra Valuable as Markers of Fitness Status in Racehorses? A Pilot Study
Authors: Grzędzicka Jowita , Dąbrowska Izabela , Kiełbik Paula , Perzyna Maciej , Witkowska-Piłaszewicz Olga
Published: November 2023

In a recent study, in which more than a thousand racehorses were evaluated, three potential blood markers were selected. It was concluded that insulin-like growth factor 1 (IGF1), interleukin-1 receptor antagonist (IL-1ra), and matrix metalloproteinase 2 (MMP2) may enable the early detection of horses at risk of injuries. However, in other studies, it was suggested that cytokine concentrations indicate the athlete’s status better than mRNA expression in blood cells. Thus, the purpose of this study was to evaluate changes in IGF1, MMP-2, and novel markers such as interleukin-13 (IL-13) after exercise in horses at different fitness levels as well as after different intensities of exercise. ELISA tests were performed on thirty-one racehorses [n = 31], who were divided into an inexperienced [beginner] group [n = 20] and an experienced [advanced] group [n = 6]. In addition, differences between race and training session were evaluated to see the influence of different intensities of exercise. Blood samples were taken before and after exercise. The basal IGF1 concentration was lower in an inexperienced group (p < 0.01) as well as IL-13 (p < 0.05) in comparison to the experienced group. There were no differences between pre- and post-exercise samples, changes in multiples or between training, and racing exercises. In conclusion, the basal values of some cytokines may appear to be more beneficial in forecasting horse fitness level.
Effects of Foliar Spraying of Organic Selenium and Nano-Selenium Fertilizer on Pak Choi (Brassica chinensis var. pekinensis. cv. ‘Suzhouqing’) under Low Temperature Stress
Authors: Wang Yanyan , Tan Guozhang , Chen Jiao , Wu Jianfu , Liu Shiyu , He Xiaowu
Published: November 2023

The effects of foliar spraying of organic selenium and nano-selenium fertilizer on pak choi (Brassica chinensis var. pekinensis. cv. ‘Suzhouqing’) under low temperature were investigated. The impacts on plant growth, antioxidant capacities, and nutritional profiles were studied. Exogenous selenium was applied at three rates: 5, 10, 20 mg L−1, and RNA-Seq technology was used to sequence the transcriptome of leaves. The study revealed that selenium influenced leaf weight and total selenium content through three main mechanisms. First, it protected photosynthetic pigments and boosted photosynthetic capacity by up-regulating LHca2, LHcb1, LHca1, and LHcb4. Second, it enhanced antioxidant capacity by elevating the expression of genes such as superoxide dismutase and monodehydroascorbic acid. Third, it facilitated selenium absorption through endocytosis, transported selenium using the ABC transport gene family, and regulated selenium metabolism-related genes like cysteine synthetase and glutaredoxin. Nine hub genes identified with a weighted gene co-expression network analysis were closely associated with these mechanisms. The results of a functional enrichment analysis were consistent with those of a Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis conducted on DEGs, thus confirming the reliability of these findings. Therefore, this study can provide scientific basis for pak choi production with selenium fortification by selenium application.
Optimized Farmland Mulching Improves Rainfed Maize Productivity by Regulating Soil Temperature and Phenology on the Loess Plateau in China
Authors: Zhang Shibo , Xia Zhenqing , Zhang Guixin , Bai Jingxuan , Wu Mengke , Lu Haidong
Published: November 2023

Owing to global warming, continuously increasing the grain yield of rainfed maize is challenging on the Loess Plateau in China. Plastic film mulching has been extensively utilized in dryland agriculture on the Loess Plateau. However, higher topsoil temperatures under film mulch caused rainfed-maize premature senescence and yield loss. Here, we aimed to explore the influence of topsoil temperature driven by novel double mulching patterns on rainfed maize productivity based on the excellent moisture conservation function of plastic film. A maize field experiment was conducted in two different areas, namely Changwu, a typical semi-arid area, and Yangling, a dry semi-humid area. The experiment followed a randomized block design with three replications. Five flat-planting practices were examined in 2021 and 2022: (1) bare land (CK), (2) transparent film mulching (PFM), (3) black film mulching (BFM), (4) double mulching of PFM with a black polyethylene net (PFM + BN), and (5) double mulching of PFM with whole maize stalks (PFM + ST). Soil hydrothermal conditions, maize growth dynamics, grain yield, water use efficiency (WUE), and economic returns were quantified under different mulching practices. Under double mulching treatments, topsoil temperatures were lower than PFM by 1.7–2.0 °C at the two sites (p < 0.05), whereas BFM was slightly lower than that of PFM by 0.6–0.7 °C at Yangling (p > 0.05). The average growth period for maize under double mulching was longer than that under PFM by 8–11 days at the two sites. Double mulching treatments significantly improved the leaf area index (LAI), chlorophyll relative content (SPAD), and aboveground biomass compared to CK and PFM during the late growth stage. Compared with PFM, average grain yield increased by 14.93%, 18.46%, and 16.45% in Changwu (p < 0.05) under BFM, PFM + BN, and PFM + ST, respectively, and by 2.71%, 24.55%, and 20.38% in Yangling. The corresponding WUEs also increased. Additionally, net income under BFM was higher than that under other treatments, and there were no significant (p > 0.05) differences between PFM + ST and BFM in Changwu. However, PFM + ST in net income averaged 10.72–52.22% higher than other treatments, and its output value was 19.51% higher in Yangling. In summary, smallholder farmers can adopt PFM + ST to improve rainfed-maize productivity in the Loess Plateau in China.
Local Beneficial Microorganisms Impact Carbon and Nitrogen Mineralization in a Lixisol Incubated with Organic Waste Products
Authors: Noumsi-Foamouhoue Emmanuel , Legros Samuel , Fernandes Paula , Thuriès Laurent , Assigbetsé Komi , Kane Aboubacry , Feder Frédéric , Médoc Jean-Michel
Published: November 2023

Growing awareness of the environmental impact of intensive agriculture has prompted a quest for more sustainable approaches. The most promising alternatives include the application of organic waste products (OWPs), as well as biofertilizers containing local beneficial microorganisms (BMs) on cultivated soils. This study was designed to assess the effects of BMs on carbon and nitrogen mineralization of OWPs. A 28-day laboratory incubation experiment was conducted at 28 °C with a soil, three OWPs (poultry litter (PL), cow dung (CD), and sewage sludge (SS)), and three BMs (groundnut + millet from Saint-Louis (LGM), groundnut from the southern groundnut basin (BG), and rice from the southern groundnut basin (BR) in Senegal), alone and combined. The results showed that the C mineralization from OWP + BM + soil mixtures exceeded (range 13–41%) those measured for OWP + soil. The BM input induced an increase or reduction in OWP nitrogen mineralization, depending on the type of BM and OWP. However, the net mineral nitrogen (Nmin) obtained with the PL-LGM and SS-BG combinations was 13.6- and 1.7-fold higher than with PL and SS, respectively, at 28 days. The addition of BM seemed to lead to a decrease in the C: N ratio, an improvement in the availability of nitrogen, and an increase in microbial activity in the OWP + BM + soil mixture. Our results generated new information on the variation patterns of OWP carbon and nitrogen in OWP-BM-soil systems. This novel insight will be developed to guide the most appropriate choice of OWP-BM mixtures for improved fertilization in sustainable production systems.
A Performance Analysis of a Litchi Picking Robot System for Actively Removing Obstructions, Using an Artificial Intelligence Algorithm
Authors: Wang Chenglin , Li Chunjiang , Han Qiyu , Wu Fengyun , Zou Xiangjun
Published: November 2023

Litchi is a highly favored fruit with high economic value. Mechanical automation of litchi picking is a key link for improving the quality and efficiency of litchi harvesting. Our research team has been conducting experiments to develop a visual-based litchi picking robot. However, in the early physical prototype experiments, we found that, although picking points were successfully located, litchi picking failed due to random obstructions of the picking points. In this study, the physical prototype of the litchi picking robot previously developed by our research team was upgraded by integrating a visual system for actively removing obstructions. A framework for an artificial intelligence algorithm was proposed for a robot vision system to locate picking points and to identify obstruction situations at picking points. An intelligent control algorithm was developed to control the obstruction removal device to implement obstruction removal operations by combining with the obstruction situation at the picking point. Based on the spatial redundancy of a picking point and the obstruction, the feeding posture of the robot was determined. The experiment showed that the precision of segmenting litchi fruits and branches was 88.1%, the recognition success rate of picking point recognition was 88%, the average error of picking point localization was 2.8511 mm, and an overall success rate of end-effector feeding was 81.3%. These results showed that the developed litchi picking robot could effectively implement obstruction removal.