bluuebunny/crossref_metadata_2025 huggingface dataset:
A TRAGÉDIA DA MACONHA ANUNCIADA PELO DISCURSO MÉDICO-PSIQUIÁTRICO
Authors: Quintela Júlia Carvalho Van der Ley , Oliveira Daniele
Published: February 2025

Este artigo propôs-se a investigar como o uso da maconha é reconfigurado no discurso médico veiculado pelo texto A tragédia da maconha: causas, consequências e prevenção, uma cartilha publicada pelo Conselho Federal de Medicina (CFM). O interesse neste documento justifica-se tendo em vista que este veicula o posicionamento oficial de uma autarquia que detém o poder constitucional de normatização da prática médica no Brasil. Sendo assim, o documento oficial produzido pela entidade tem o potencial de moldar os discursos e práticas sociais referentes à questão das drogas no país, bem como pautar a constituição de políticas públicas que produzem efeitos diretos para os cidadãos em nível legal e sanitário. Desse modo, acionamos os Estudos Críticos do Discurso como recurso para identificar as relações de poder presentes e analisar como estas se articulam no discurso veiculado pelo texto em tela. O discurso do Conselho Federal de Medicina, materializado na seção de apresentação do texto, articula o discurso da medicina baseada em evidências, o discurso proibicionista e o discurso moral cristão. Esse entrecruzamento de discursos gera uma configuração discursiva particular produtora e produzida por relações de poder que estão à serviço de um projeto político de desmonte das políticas públicas de saúde mental baseadas no cuidado em liberdade e na dignidade humana.
A (IM)PREVISIBILIDADE DA EXCLUSÃO NAS SALAS DE AULA REGULARES
Authors: Barros Renata Chrystina Bianchi de , Silva Priscilla Ferreira e
Published: February 2025

Este texto do tipo ensaio revisita uma experiência didática por meio da problematização entorno da educação inclusiva e a formação de professores. O retorno a essa experiência destacou a importância de suspender as certezas relacionadas à previsibilidade das experiências profissionais e dos processos didáticos. Fundamentado na Análise de Discurso, a argumentação é circunscrita na temática da inclusão e homogeneização das práticas de ensino pela adaptação de recursos didáticos. O texto suspende as certezas sobre as adaptações curriculares, ressaltando a necessidade de uma abordagem crítica e reflexiva para promover a transformação de paradigmas na educação inclusiva.
O NEGACIONISMO CLIMÁTICO NO BRASIL
Authors: Busnardo Juliano Momenti , Mendonça Marina Célia
Published: February 2025

Esta pesquisa pretende analisar uma entrevista de Ricardo Felício, no Programa do Jô, do ano de 2012. Nesta entrevista, o professor da USP fala sobre “a farsa do aquecimento global” e comenta sobre o tema, suscitando o discurso do negacionismo climático. Tendo essa entrevista como corpus, o objetivo do artigo é entender como o discurso de Ricardo Felício se constitui na relação com o discurso científico sobre mudanças climáticas e o aquecimento global e responder às seguintes questões: 1. Como o discurso sobre o aquecimento global na esfera científica se constitui em relação a outras esferas discursivas?; 2. Qual a importância da entonação e da avaliação no discurso de Ricardo Felício na  relação com seu outro?; 3. Como o discurso de Ricardo Felício manifesta seu aspecto pseudocientífico? Para compreender este tema, esta pesquisa parte da Análise Dialógica do Discurso, baseando-se em Bakhtin, Volóchinov e seus comentadores no Brasil. Conclui-se que o discurso de Ricardo Felício pode ser entendido como pseudocientífico, no entanto, para compreender o discurso do negacionismo climático, é necessário ir além da esfera científica, entendendo que esse discurso constitui uma “controvérsia científica fabricada”, fundamentando-se e ganhando popularidade pelos elementos extracientíficos, ou seja, de outras esferas, como a política, econômica, jornalística.
Rede criativa Bridgerton e suas ações de marketing
Authors: Câmara Naiá Sadi , De Andrade Henrique Botelho
Published: February 2025

Compreendendo redes criativas como aglomerações de criativos, de produtores culturais, compostas pelos ativos criativos, pela produção e distribuição dos bens simbólico-culturais, e como eixos promissores de projetos de desenvolvimento regional (Autor 2, 2018), nossa pesquisa objetivou analisar como a rede criativa Bridgerton se constitui, verificar seus desdobramentos em ações de marketing para divulgação tanto da própria série quanto das marcas associadas para discutirmos o papel desse tipo de rede na constituição das sociedades. A rede nasce com a série de livros Os Bridgertons, de Julia Quinn, e, recebeu em 2020 uma adaptação para o gênero audiovisual pela Netflix. A partir desse processo transmidiático, o universo ficcional, construído inicialmente para uma série de livros, converte-se em uma rede criativa, que se expande para além das redes digitais. A metodologia do estudo deu-se por meio da metodologia de análise dos Letramentos transmídia (Autor 1, 2018; Autor 3, 2019) e as dimensões escolhidas para apresentação neste artigo foram gêneros, formatos, linguagens, transmidiações, interação e transnacionalidade. Posteriormente, foram realizadas duas análises de ações de marketing que envolviam o universo ficcional de Bridgerton e marcas nacionais e internacionais. Os resultados revelam que a rede criativa Bridgerton se constitui a partir da tradução transmídia dos romances para a narrativa seriada audiovisual, mantendo elementos, mas adaptando-se ao novo formato e às pautas sociais contemporâneas. Com relação à divulgação da rede e das marcas associadas, elementos que compõem a rede são conectados aos produtos de marcas de luxo, extrapolando o universo ficcional e possibilitando maior engajamento dos consumidores.
ANÁLISE DO DISCURSO POLÍTICO-MIDIÁTICO DO JORNAL GAZETA DO CERRADO
Authors: Boucher Damião Francisco , Soares Thiago Barbosa
Published: February 2025

Este artigo analisa o discurso político-midiático, procurando investigar como efeitos de sucesso midiático aplicados ao campo político podem modificar a imagem de sujeitos a partir de outros efeitos de sentidos como do âmbito das redes sociais. Por meio desse expediente, pretende-se examinar os sentidos do sintagma “O Dudu tá on” e outros pré-construídos da esfera das redes sociais e como tais enunciados projetam e produzem sujeitos políticos investidos de sucesso midiático. Para tal investigação, utilizam-se os ferramentais teórico-metodológicos da Análise do Discurso, especificamente, as noções de interdiscurso, intradiscurso, formações ideológicas, formações discursivas, processamentos metafóricos, polissêmicos, parafrásticos, pré-construídos, bem como outros de igual potencial heurístico. Como corpus a ser examinado, tem-se a materialidade midiática “‘O Dudu tá on’ Eduardo Siqueira garante obra da ponte da integração no Bertaville, agradece bancada e movimenta redes com interações com moradores”, publicada no site Gazeta do Cerrado, em 6 de janeiro de 2025. Por fim, sopesa-se o batimento descritivo-interpretativo, verificando as dimensões do discurso do sucesso midiático nas redes de sentidos que projetam Eduardo Siqueira Campos como sujeito de sucesso político.
Stock Repurchase and Corporate Governance : Empirical Evidence in Korean Market
Authors: Woo Seungyub , Kim Noolee , Kim Hyemin
Published: February 2025

We analyze the influence of corporate governance on share repurchase policies in Korean listed firms from 2013 to 2021 and examine the features of share repurchases in the Korean market. Results reveal that firms with higher corporate governance ratings are more likely to pay dividends but less likely to engage in share repurchases than firms with lower governance ratings. Moreover, market reactions to share repurchase announcements are more positive for firms with higher governance ratings than for those with lower governance ratings. While investors react negatively to treasury share sales announcements, these negative effects are stronger for firms with lower governance ratings than for firms with higher governance ratings. Overall, our findings suggest that, in the Korean market, share repurchases are partly used to protect the control of controlling shareholders rather than to serve their original purpose of payout to shareholders.
COVID-19 vaccine effectiveness in the paediatric population aged 5–17 years: a multicentre cohort study using electronic health registries in six European countries, 2021 to 2022
Authors: Soares Patrícia , Machado Ausenda , Nicolay Nathalie , Monge Susana , Sacco Chiara , Hansen Christian Holm , Meijerink Hinta , Martínez-Baz Iván , Schmitz Susanne , Humphreys James , Fabiani Massimo , Echeverria Aitziber , AlKerwi Ala’a , Nardone Anthony , Mateo-Urdiales Alberto , Castilla Jesús , Kissling Esther , Nunes Baltazar ,   VEBIS-Lot 4 working group
Published: February 2025

Background

During the first year of the COVID-19 pandemic, vaccination programmes targeted children and adolescents to prevent severe outcomes of SARS-CoV-2 infection.

Aim

To estimate COVID-19 vaccine effectiveness (VE) against hospitalisation due to COVID-19 in the paediatric population, among those with and without previously documented SARS-CoV-2 infection.

Methods

We established a fixed cohort followed for 12 months in Denmark, Norway, Italy, Luxembourg, Navarre (Spain) and Portugal using routine electronic health registries. The study commenced with paediatric COVID-19 vaccination campaign at each site between June 2021 and January 2022. The outcome was hospitalisation with a laboratory-confirmed SARS-CoV-2 infection or COVID-19 as the main diagnosis. Using Cox proportional hazard models, VE was estimated as 1 minus the confounder-adjusted hazard ratio of COVID-19 hospitalisation between vaccinated and unvaccinated. A random-effects meta-analysis was used to pool VE estimates.

Results

We included 4,144,667 5–11-year-olds and 3,861,841 12–17-year-olds. In 12–17-year-olds without previous infection, overall VE was 69% (95% CI: 40 to 84). VE declined with time since vaccination from 77% ≤ 3 months to 48% 180–365 days after immunisation. VE was 94% (95% CI: 90 to 96), 56% (95% CI: 3 to 80) and 41% (95% CI: −14 to 69) in the Delta, Omicron BA.1/BA.2 and BA.4/BA.5 periods, respectively. In 12–17-year-olds with previous infection, one dose VE was 80% (95% CI: 18 to 95). VE estimates were similar for 5–11-year-olds but with lower precision.

Conclusion

Vaccines recommended for 5–17-year-olds provided protection against COVID-19 hospitalisation, regardless of a previously documented infection of SARS-CoV-2, with high levels of protection in the first 3 months of the vaccination.
Pengembangan Media E-Learning Koi Park Berbasis Scan QR Android pada Mata Pelajaran Kewirausahaan di SMK Negeri 1 Udanawu
Authors: Wahyudi Erlik Prasetyo , Tuwoso Tuwoso , Prasetya Didik Dwi
Published: February 2025

Saat ini teknologi telah mengubah paradigma cara mengajar pendidik dan cara belajar peserta didik dalam memperoleh berbagai sumber informasi pembelajaran. Mata pelajaran Kewirausahaan di SMK menuntut guru untuk memberikan implementatif pada dunia nyata dalam menyajikan materi literasi kewirausahaan, sehingga dapat mengembangkan potensi UMKM di sekitar kawasan sekolah. Salah satu potensi UMKM adalah budidaya ikan Koi di Desa Kemloko, Kecamatan Nglegok, Kabupaten Blitar. Penelitian ini bertujuan untuk mengembangkan aplikasi media e-learning Koi Park Blitar berbasis Scan QR Android pada mata pelajaran Kewirausahaan menggunakan model ADDIE. Media pembelajaran tersebut layak digunakan dengan hasil validasi oleh ahli materi 96,15 (sangat layak) dan ahli media 92,30 (sangat layak).
Pengembangan Game Literasi Numerasi berbasis RPG Maker MV
Authors: Eldiana Novia Frisda , Zainuddin Muhammad , Arifin Slamet
Published: February 2025

Penelitian ini bertujuan untuk mengembangkan game literasi numerasi berbasis RPG Maker MV berupa game yang dintyatakan valid dan game yang dinyatakan praktis. Metode yang digunakan dalam penelitian ini adalah penelitian pengembangan dengan model prototyping menurut nieveen yang memiliki tahapan; 1) preliminary research, 2) prototyping stage, dan 3) assessment stage. Instrumen yang digunakan yaitu lembar wawancara dan lembar angket. Lembar wawancara digunkan untuk menggali informasi tentang kebutuhan sekolah, sedangkan lembar angket digunakan untuk validasi dan respon kepraktisan game. Validitas game ditentukan dari hasil validasi oleh dosen pakar matematika dan guru. Kepraktisan diperoleh dari pengisian angket respon dari penggunakan game oleh siswa dan guru. Subjek uji yaitu siswa sekolah dasar di kecamatan durenan khususnya siswa kelas V. Uji coba terbatas dilakukan pada 7 siswa dan uji coba lapangan dilakukan pada 21 siswa. Perangkat yang dihasilkan dapat dikatakan baik apabila memenuhi kriteria valid dan praktis. Hasil validasi game yaitu 85,7 dari ahli media. Hasil validasi dari ahli materi terdiri 91,6 dari dosen dan 88,9 dari guru. Hasil angket kepraktisan respon siswa 90,6 dan angket kepraktisan respon guru 92,6. Jadi kesimpulannya game literasi numerasi berbasis RPG Maker MV valid dan praktis digunakan dalam proses pembelajaran.Â
Model Pendekatan Komponen Pariwisata 6A Di Desa Mondoluku Menuju Desa Wisata
Authors: Andri Krisna Dianto  , Ardiansyah Hendra Lukmana  , Longinus Lozha  , Rahayu Antasari
Published: February 2025

Desa Mondoluku untuk menjadi Desa wisata memiliki keberagaman potensi yang belum dikelola secara optimal, maka perlu dilakukan analisis dengan model komponen pariwisata 6A yakni Attraction, Accessibilities, Amenities, Accommodation, Activity dan Ancillary Service sebagai model dalam pengembangan dan pembangunan desa wisata Mondoluku. Kesiapan desa Mondoluku dengan analisis model pendekatan komponen pariwisata 6A, sebagai model pengelolaan dan pengembangan pariwisata di Desa Mondoluku, sehingga pengunjung atau wisatawan dapat menikmati potensi-potensi wista yang ada di Desa Mondoluku, serta diharapkan dapat memberikan peluang pada masyarakat umtuk memanfaatkan potensi-potensi yang ada untuk mendukung keberlangsungan kegiatan pariwisata.  Tujuan Penelitian yakni menganalisis model pendekatan komponen pariwisata 6A serta menganalisis faktor pendukung dan penghambat dalam pengembangan desa wisata di Desa Mondoluku menuju desa wisata. Jenis penelitian ini yakni deskriptif kualitatif dengan teknik pengumpulan data dengan observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan pengembangan pariwisata di Desa Mondoluku masih belum optimal, masih ada yang perlu diperbaiki dalam masing-masing komponen pariwisata tersebut pada setiap potensi tempat wisata yang ada di Desa Mondoluku
Financial performance analysis of automobile industry after Covid-19 Pandemic
Authors: Yadav Veena , Bansal Tina
Published: February 2025

The COVID-19 pandemic had a profound impact on the global automobile industry, disrupting supply chains, reducing consumer demand, and altering production strategies. This research paper provides a comprehensive financial performance analysis of the automobile industry post-COVID, focusing on key financial indicators such as revenue growth, profitability, liquidity, and market capitalization. Using a comparative approach, this study examines financial data from major automobile manufacturers worldwide, highlighting the variations in recovery trends across different regions and market segments. The analysis incorporates key financial metrics such as Return on Assets (ROA), Return on Equity (ROE), Earnings Before Interest and Taxes (EBIT), and debt-equity ratios to assess the financial health of the industry. Additionally, the study explores the role of government stimulus packages, digital transformation, and shifts in consumer preferences towards electric vehicles (EVs) and sustainable mobility solutions. The findings indicate that while the automobile industry has shown signs of recovery, the pace of financial rebound varies among companies, influenced by factors such as operational efficiency, technological adaptation, and market demand. This research contributes to the existing literature by offering a data-driven evaluation of the industry's financial resilience, providing insights for investors, policymakers, and industry stakeholders to navigate future uncertainties effectively.
Cultural Hybridity and Assimilation: Exploring the Immigrant Experience in Jasmine
Authors: Bundela Varsha Raja , Saxena Rashmi
Published: February 2025

This research paper examines cultural hybridity and assimilation as central themes in Bharati Mukherjee’s novel Jasmine, exploring the immigrant experience through the transformative journey of its protagonist. Jasmine’s evolution from Jyoti, a traditional village girl in India, to her multiple identities in the United States Jasmine, Jazzy, Jase, and Jane highlights the fluid and dynamic nature of identity. The narrative captures the tension between cultural assimilation and resistance, illustrating the challenges and opportunities faced by immigrants in navigating the complexities of a new cultural landscape. Drawing upon theories of cultural hybridity, such as Homi K. Bhabha’s “Third Space,” this paper explores how Jasmine negotiates between her Indian heritage and American norms, crafting a unique identity that transcends rigid cultural binaries. The analysis further delves into the interplay of gender and culture, showcasing how Jasmine challenges patriarchal constraints and redefines her agency within a multicultural context.
This study situates Jasmine within the broader discourse of diasporic literature, emphasizing its relevance in understanding the psychological, emotional, and social dimensions of migration. By portraying Jasmine’s journey as both a struggle and a process of empowerment, Mukherjee provides a nuanced exploration of the immigrant experience, shedding light on the transformative potential of cultural hybridity. This paper contributes to the understanding of identity formation in a globalized world, where cultural negotiation and assimilation remain vital to the immigrant narrative.
ELECTRICALLY CONDUCTIVE FILMS - CHARACTERISATION OF WEIGHT-REDUCED POLYMER FILMS FOR USE IN A BIPOLAR LITHIUM-SULPHUR BATTERY
Authors: Engelke Martin , Hickmann Thorsten Manfred , Krause Beate
Published: February 2025

With a theoretical energy density of around 2600 Wh kg-1 and a specific capacity of approx. 1675 mAh g-1, the lithium-sulphur battery (Li-S battery) is a promising technology for future energy storage solutions. Lithium-sulphur batteries currently achieve specific energy densities of between 400 and 600 Wh kg-1 in practical applications, making them an attractive alternative to lithium-ion batteries. Despite their advantages, technical challenges such as the dissolution of polysulphides in the electrolyte and the low cell voltage are significant obstacles to the commercialisation of this technology. In the "BiPoLiS" project (development of lithium-sulphur bipolar batteries), these challenges are addressed by combining lithium-sulphur battery technology with a previously undescribed bipolar structure. The focus of this article is on the development of weight-reduced polymer conductor foils, which should contribute to an improved battery packing density due to the planar layer structure - compared to single cells.Experimental investigations were carried out to develop an electrically conductive, flexible and weight-reduced film suitable for use in lithium-sulphur batteries. The investigations were based on compounds of styrene-ethylene-butylene-styrene (SEBS) and polypropylene (PP), whereby various mixing ratios were tested. The optimum mixture was found with a ratio of a SEBS compound to a PP compound of 30:70, which had an electrical in-plane conductivity of around 346 S m-1 and a through-plane conductivity of around 60 S m (-1). The flexible film was produced using a calendering process, whereby a thickness of approx. 0.2 mm was achieved.Thanks to the innovative combination of bipolar design and polysulphide-free sulphur cathode, the lithium-sulphur battery can offer significant advantages in terms of energy density and manufacturing costs. This technology could play a decisive role, particularly in the field of electromobility and industrial energy storage. Future work should focus on optimising the process parameters for reducing the film thickness and investigating the long-term stability in order to exploit the full potential of these new materials and enable their commercial applications.
ALTERED DISTINCTION: A CRITICAL STUDY OF THE MIND AND THE BODY IN THE CASE OF ALTERED CARBON
Authors: Kamboj Lakshay Kumar
Published: February 2025

Altered Carbon is a Netflix original series in two parts. The First part is created by Laeta Kalogridis, and adapted from the novel, by the same title, written by Richard K. Morgan in 2001. In this Cyberpunk genre series, a new human subjectivity is represented in the series, in which a Transhuman state is imagined. In the series, human mind can be stored in ‘Cortical Stacks’ and can be transferred into changeable bodies indefinitely thereby making humans immortal. It can also be spun up in the virtual for any purpose such as interrogation, torture or a virtual meeting. Bodies can be manufactured, real or synthetic and commodified. But these capabilities also result in unfair handling and exploitation of both mind and body. Hence, this detailed content analysis will study these conflicts and issues of ‘altered carbon’ with the perspectives of the mind/body as actually distinct substances as suggested by Rene Descartes. He argues that mind and the body differ in their natures, which makes it possible for one to exist without the other. These characteristics seem to adhere to the mind/body distinction as demonstrated in the series, which will help the paper explore the problems of a Transhuman state. In conclusion, with this paper, I would be critically analyzing the altered human subjectivity and its consequences in the series.
TRADITIONAL KNOWLEDGE AND SUSTAINABLE DEVELOPMENT
Authors: Manjari Chandra  , Shabran Rohit P
Published: February 2025

This paper looks at how IP laws have attempted to safeguard conventional knowledge and how it may be stolen. Although traditional knowledge is protected by the Biodiversity Act, there have been cases of bio-piracy involving traditional medical knowledge and the usage of plants to treat a range of illnesses. The author will explain the need to preserve traditional knowledge and the idea of bio-piracy using the three well-known Indian examples of neem, turmeric, and basmati rice.In addition, I'll investigate whether there are any constitutional protections for sacred traditional knowledge. To preserve TK, several international agreements have been put into effect. Global issues including food security, environmental degradation, and sustainable livelihoods can be addressed by combining traditional knowledge with contemporary scientific methods. The role of traditional knowledge in intellectual property protection has been a hot topic of debate ever since the 1992 Convention on Biological Diversity and the 1995 TRIPS agreement.A single solution is unlikely to be able to address the vast array of issues and goals related to TK protection. Since TK is essential to the existence of many indigenous people, care should be made to protect it. With a focus on its applicability to accomplishing the Sustainable Development Goals of the UN, this article examines the complementary relationship between traditional knowledge and sustainable development. While a complete sui generis legal framework is being developed, traditional knowledge can be secured by utilizing already-existing forms of intellectual property or by combining multiple different types of IP.
Generative adversarial neural network with graph embeddings for de novo designing small-molecule inhibitors against Mycobacterium tuberculosis KasA enzyme
Authors: Gonchar A. V. , Furs K. V. , Tuzikov A. V. , Andrianov A. M.
Published: February 2025

A generative semi-supervised adversarial neural network trained on graph embeddings was developed for de novo design of potential inhibitors against beta-ketoacyl-[acyl-carrier protein] synthase I (KasA), an enzyme critically important for biosynthesis of mycolic acids of the Mycobacterium tuberculosis cell wall. The designed model was trained and tested on a set of compounds from a virtual library of small molecules containing structural elements capable of selective interactions with the therapeutic target. Using the developed neural network, 3,637 compounds were de novo designed, followed by assessment of their inhibitory activity against the KasA protein using molecular docking methods. Based on the analysis of the obtained data, six compounds exhibiting high affinity to the malonyl-binding site of the enzyme were selected. The identified compounds are assumed to form promising basic structures for further theoretical and experimental studies on the development of new effective inhibitors of drug-resistant tuberculosis.
Variability of secondary metabolites in the bark of Rhamnus cathartica L. from native and introduced population
Authors: Spirydovich A. V. , Shabunya P. S. , Ahabalayeva A. D. , Deeva A. A. , Vinogradova Yu. K. , Vlasava N. B. , Kost M. A. , Reshetnikov V. N.
Published: February 2025

The European buckthorn (Rhamnus cathartica L.) – a shrub native to most parts of Europe and Western Asia – has been successfully naturalized in the Midwest and Northeast of the USA, dominating various habitats and displacing native species. It is known that Rhamnus cathartica L. plants contain a wide range of secondary metabolites with pharmacological effects. Permanent sample plots with R. cathartica – the species native for Belarus (two sites) and invasive in the USA (two sites) – were selected. This study investigated the level of anthraquinones, catechins, and leucoanthocyanins, and identified anthraquinones using HPLC with mass spectrometry and UV detection, showing a significant variation in these indicators depending on the conditions and the geographical area of growth. Rhamnus cathartica chemorases were identified, which will allow further isolation of samples with a required set of phenolic compounds and a directed selection for obtaining artificially introduced populations with an increased content of one or another valuable compound.
Simulating of radar signals of unmanned aerial vehicles for non-Gaussian distributions of complex amplitudes
Authors: Kostromitsky S. M. , Nefedov D. S. , Dyatko A. A.
Published: February 2025

The structure and functioning algorithms of the simulator of radar signals reflected from small-sized unmanned aerial vehicles (UAVs) have been developed. A specific feature of the simulator is the ability to generate arbitrarily correlated signal implementations of the radar input influence for the cases where the random amplitude of the reflected signal (RS) has a Rayleigh, Nakagami, Weibull or lognormal distribution. Analytical expressions are presented for calculating the parameters of the probability density function, as well as generating samples of the random amplitude of the RS with a given distribution law from the samples of the initial implementations of the Gaussian process. Provision is made for normalizing the RS average power to the average value of the modeled target RCS and a specified correlation time for fluctuations of RS complex amplitudes is ensured. The parameters of the generated RS implementations correspond to the values of real radar characteristics of small-sized UAVs obtained experimentally. The application of the proposed simulator is to analyze the effectiveness of newly developed and known UAV detection algorithms using the mathematical modeling method.
Effect of temperature, microstructure and intramolecular dynamics of fibrillary collagen on apatitogenesis in scaffolds
Authors: Gaidash A. A. , Kulak A. I. , Krut’ko V. K. , Musskaya O. N. , Kulchitsky V. A. , Skrotskaya K. V. , Kulbitskaya L. V. , Krutsko E. N.
Published: February 2025

The structure and physicochemical properties of scaffolds obtained from collagen gel using connective tissue sheaths of paravertebral tendons of Wistar rats were studied. The scaffolds were obtained at 37 °C (filmy) and 6 °C (volumetric). During hardening, the scaffolds form globular and extraglomerular fractions, which is typical for collagen gels obtained from tendon membranes. The ratio of the fraction volumes is determined by the pore structure and kinking of collagen fibrils. In the filmy scaffold, closed-type pores with weakened kinking are formed, which leads to the dominance of the extraglomerular scaffold. In the volumetric scaffold, kinking is intensified, open-type pores are formed, which determines the dominance of the globular scaffold. The morphogenetic factors of dominant fraction formation are ordering and increased rigidity, while the subdominant fractions are chaotization and elasticization of collagen frameworks. Fibrillar collagen undergoes extra- and intrafibrillar mineralization in situ with structuring of calcium phosphates along the apatite direction. The micromechanical properties of scaffolds induce extrafibrillar synthesis and determine the direction of apatitogenesis: stoichiometric hydroxyapatite is synthesized on rigid matrices, while carbonate-hydroxyapatites are synthesized on loose ones. Intrafibrillar synthesis in combination with temperature determines the degree of crystallinity and the composition of cationic and anionic sublattices of hydroxyapatites. On matrices of fibrillar collagen with strengthened bonds of peptide and carbonate groups, stoichiometric hydroxyapatite is formed, the degree of crystallinity of which is moderated by temperature − the higher the synthesis temperature, the higher the degree of crystallinity and saturation with calcium would be. On matrices with weakened peptide and C−O bonds, carbonate-hydroxyapatites are formed, in which substitutions in the anionic sublattice are regulated by temperature: at elevated temperatures, CO32– groups predominantly replace OH–, and at lower temperatures, PO43– groups.
Clinical and microbiological characteristics of viral-bacterial pneumonia caused by Klebsiella pneumoniae in SARS-CoV-2 infected patients
Authors: Levchenko K. V. , Mitsura V. М. , Tapalski D. V. , Karpova E. V. , Bondarenko V. N.
Published: February 2025

The object of study was to investigate the clinical and laboratory characteristics, the outcomes of the disease, the susceptibility to antibiotics and to different combinations in the patients with pneumonia caused by K. pneumoniae associated and not associated with COVID-19.

We analysed 93 cases of pneumonia with K. pneumoniae detected in biological materials including 65 ones with COVID-19 and 28 ones without COVID-19.

In the both groups, the diseases of the circulatory system and metabolic disorders were the most common concomitant conditions. The laboratory data were not statistically different. The lethal outcomes were found reliably more often in the patients with COVID-19 (66 % vs 32 %).

 K. pneumoniae was detected predominantly after the tenth day of admission to the hospital (nosocomial strains). In the both groups, the majority of detected K. pneumoniae strains had a multiple resistance to antibiotics. The combinations of antibiotics with no colistin demonstrated a low efficacy, including those with carbapenems. A proportion of 40 (61.5 (48.6–73.3) %) K. pneumoniae samples isolated from patients with COVID-19 had carbopenemases detected.

The results of the study refer to the preferability of the colistin comprising the schemes of antibiotics for treatment  of pneumonia caused by K. pneumoniae associated and not associated with COVID-19.
Bacterial ligands in complex treatment of community-acquired pneumonia in organized groups
Authors: Kostinov M. P. , Zverev V. V. , Tatevosov V. R. , Gainitdinova V. V. , Polishchuk V. B. , Osiptsov V. N. , Guban’ V. I. , Yastrebova N. E. , Kurbatova E. А. , Markelova E. V. , Shubin I. V.
Published: February 2025

Despite the successes achieved in treating community-acquired pneumonia (CAP), tactics still need to be  improved, especially when forming new organized collectives of military personnel.

The purpose of the study was to examine clinical and immunological features of action of an immunotropic drug of bacterial origin Immunovac-VP-4 in complex treatment of mild community-acquired pneumonia in newly recruited military personnel.

The study included 35 patients (main group 1) hospitalized with mild CAP who, in addition to basic antibacterial therapy, were treated with the Immunovac-VP-4 vaccine. Control group 2 consisted of 53 patients who received only basic antibacterial therapy. Immunovac-VP-4 contains lysates of Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli and was prescribed according to the nasal-subcutaneous regimen from 1 to 13 days of hospital stay. The mechanism  of action is based on activating key effectors of innate and adaptive immunity.

 In the main group there were an increase of respiratory function indicators, production of IgG antibodies to all antigens of the drug, a relative decrease in IL-6 and IFN-γ concentration in blood serum after administration of a bacterial immunomodulator.

Including the multicomponent antibacterial vaccine in subcutaneous-nasal regimen in complex treatment of mild CAP can be recommended as one of the treatment methods leading to the normalization of inflammatory mediators and the prevention of respiratory infections in this cohort of patients.
Effect of ascorbic acid on obtaining chondrogenic pre-differentiated mesenchymal stem/stromal cells
Authors: Zhernasechanka H. A. , Isaikina Ya. I.
Published: February 2025

Mesenchymal stem/stromal cells (MSCs) have unique functional properties, one of which is the chondrogenic differentiation. This population of cells is being used in clinical practice for repairing cartilage tissue. Various combinations of growth factors promote the expression of markers of hyaline cartilage, but also induce hypertrophy’s markers. There  is evidence that ascorbic acid can promote chondrogenic differentiation of MSCs by increasing the transcription of Col2, so we have studied when adding ascorbic acid to the differentiation medium to the previously developed cytokine cocktail in order to obtain a hyaline-like matrix. There is a different time of induction of chondrogenesis in MSCs, so we assumed to reduce the induction period of chondrogenic pre-differentiation of MSCs. Based on our studies we confirmed a positive effect of ascorbic acid on the expression of Col2, which indicates the possibility of obtaining strong and stable chondrogenic differentiation  of MSCs. The analysis of the expression of genes-markers of chondrogenic differentiation of MSCs and the synthesis  of extracellular matrix components on the 4th and 7th days showed a possibility of reducing the pre-differentiation period  to 4 days.
Polymorphism of the MMP-2, MMP-9, TIMP-2 genes and the expression pattern of matrix metalloproteinases types 2 and 9 of the placenta of women with recurrent miscarriage
Authors: Grinevich T. N. , Lyalikov S. A. , Shulga A. V. , Kot M. O.
Published: February 2025

Expression indices of matrix metalloproteinases (MMPs) of types 2 and 9 and polymorphism of MMP-2, MMP-9 and their tissue inhibitor (TIMP-2) genes in placental tissue of women with early reproductive losses were determined. MMP-2 expression in placental tissue preparations was found to be significantly higher among women with recurrent miscarriage in the first trimester pregnancy than in women with normal pregnancy. Associations of the mutant T allele of the 735 C/T polymorphism of the MMP-2 gene and the mutant C allele of the 418 G/C polymorphism of the TIMP-2 gene with  a high level of matrix MMP-2 expression were found. The level of MMP-9 expression in the placenta of women with recurrent miscarriage and with physiological pregnancy was not statistically significantly different.
İslâmî Dönem Şiirlerinin İstişhâd Değerine İlişkin Yaklaşımlar
Authors: Çokyürür Mehmet Zahid
Published: February 2025

Nahiv metodolojisinde şiirle istişhâd ve şair tabakaları denilince; Cahiliyye dönemi şairleri, Muhadram şairler, İslâmî dönem şairler ve Müvelled şairler şeklinde dört tabaka akla gelmektedir. Bunlardan
ilk ikisinin istişhâd değeri taşıdığı ve sonuncusunun taşımadığı noktasında nahiv bilginlerince uzlaşı
söz konusudur. Literatürde verilen bilgiye göre; mütekaddimûn veya üçüncü tabaka da denilen İslâmi dönem şairlerinin şiirleri ise sahih olan kavle göre istişhâd değeri taşısa da söz konusu dönemin
şairleriyle muasır olan meşhur dil bilginleri bu tabakanın şiirlerini istişhâda değer görmemişlerdir.
Klasik literatürde bazı kaynaklarda ve özellikle modern literatürde bu bilginlerin söz konusu tavrı takınmalarının nedeni olarak; başta Ferezdak (ö. 114/732) olmak üzere Kümeyt el-Esedî (ö. 126/744) ve
Zürrumme (ö. 117/735) gibi şairlerin şiirlerinin lahn barındırdığı veya bu şairlerin çağdaşlarınca müvelled kabul edildiği hususu gösterilmiştir. Araştırma derinleştirildiğinde ise nahiv bilginlerinin bu neslin şairlerini tenkit etmelerindeki tek nedenlerin bunlar olmadığı, bunların yanı sıra siyasi ve mezhebi
etmenlerin de bu tenkitlere yön verdiğine şahit olunmuştur. Yine ilgili bilginlerin söz konusu şairlerin
beyitleriyle ilgili birbiriyle tenakuz teşkil eden dilsel tutumlarda bulundukları da gözlenmiştir. Böylece
bu çelişki araştırmanın hareket noktasını teşkil etmiş, meseleyi çözümlemek için etraflı bir araştırma
inceleme ihtiyacı hâsıl olmuştur.
Retrospective analysis of the epidemiological profile of patients undergoing breast reconstruction in a public hospital in Northeastern Brazil
Authors: Ferreira Darley de Lima , Ferreira Nancy Cristina Ferraz de Lucena , Ferreira Thais de Lucena
Published: February 2025

Introduction: Breast reconstruction is a right guaranteed by the public health system to patients undergoing mastectomy. The present study aimed to understand the epidemiological profile of women with breast cancer who underwent breast reconstruction at a referral hospital in the Northeast region of Brazil. Methods: Observational, retrospective study with an analytical character and descriptive approach. Data were collected through a sociodemographic questionnaire and clinical-surgical history, and were subsequently analyzed using SPSS version 18, with the percentages of the categories evaluated by the χ2 test, considering a significance level of 5%. The comparison of the analyses was significant (p<0.005), demonstrating that the profile described was the most frequent in the group of patients evaluated. Results: A non-probabilistic sample of 400 medical records was obtained from a public referral hospital in the unified health system of the Northeast Region. The majority had a mean age between 46 and 59 years (45.3%) and brown skin color (61.1%), and were married (79.1%), with education up to high school (60.7%); they were housewives (45.0%), non-smokers (84.9%), non-alcohol drinkers (94.9%) and underwent immediate reconstruction after mastectomy (70.3%). Conclusions: The findings support that patients with high education levels are likely to undergo immediate breast reconstruction, indicating that socioeconomic level significantly influences the rates of breast reconstruction after radical or conservative breast surgery.
Emenda Constitucional Nº 93 DE 2016: efeitos sociais e questionamentos jurídicos
Authors: Vieira Gregório de Albuquerque , Morais Joel Helder da Silva
Published: February 2025

O artigo aborda o tema da guarda compartilhada, sintetizando os resultados de uma pesquisa sociojurídica desenvolvida em Maceió (AL). No estudo, além da consulta de fontes bibliográfi cas e documentais, foi realizada uma pesquisa de campo, na qual foram entrevistados juízes e juízas de varas de família, profissionais das equipes interdisciplinares e pais e mães que vivenciaram processos de guarda de filhos. A pesquisa teve como objetivo observar a aplicação da guarda compartilhada, bem como as concepções sobre parentalidade dos sujeitos entrevistados, de modo a verifi car a realidade desta modalidade de guarda em nosso contexto.
Ordem e efetiva formulação dos quesitos no Tribunal do Júri
Authors: Sotto-Mayor Lorena Carla
Published: February 2025

A ordem de formulação de quesitos no procedimento do Tribunal do Júri, bem como a pergunta sobre a absolvição do acusado quando a única tese é a negativa de autoria, vem provocando alguns debates na comunidade jurídica. Este estudo, através de revisão bibliográfica, narra os posicionamentos e sobreleva os argumentos que devem preponderar, segundo o ponto de vista da articulista.
O internamento compulsivo de portador de anomalia psíquica em Portugal: Breve referência à Lei brasileira de Reforma Psiquiátrica de 2001
Authors: Antunes Maria João
Published: February 2025

Traça um esboço histórico das resoluções e documentos internacionais que marcaram a problemática da saúde mental, tendo em vista, a proteção jurídica das pessoas com problemas mentais internadas como pacientes involuntários. Elucida a Lei brasileira n.º 10.216, de 6 de abril de 2001, que dispõe sobre a proteção e os direitos das pessoas portadoras de transtornos mentais.
A funcionalização da autonomia contratual e seu reflexo na formação do direito subjetivo
Authors: Bezerra Rodrigo José Rodrigues
Published: February 2025

A autonomia contratual é um direito previsto na Constituição, sendo
sua limitação um instrumento de concretização da justiça social e de proteção
de direitos fundamentais. Os direitos subjetivos deixam de ser enxergados
como um ambiente orientado exclusivamente pela vontade individual, estando
condicionado à satisfação das funções estabelecidas pelo próprio direito
objetivo, que os cria e vincula. A função social entra na estrutura da norma como
o condicionamento de validade dos signifi cados que se atribui ao texto normativo
à satisfação desses objetivos, tal como ocorre com o consequencialismo.
VIOLÊNCIA DOMÉSTICA E FAMILIAR NO BRASIL: NÚMEROS, FATOS E JUSTIÇA RESTAURATIVA
Authors: Passos Anderson Santos dos
Published: February 2025

No Brasil, os dados sobre a violência doméstica e familiar são assustadores, colocando o país dentre aqueles que possuem maiores índices de homicídios e agressões contra a mulher em todo o mundo. A Organização Mundial da Saúde considera a violência contra as mulheres uma questão de saúde pública, a mulher agredida precisa de apoio do Estado, tanto no campo psicológico como assistencial, tendo como objetivo recuperar-se do trauma sofrido, notou-se que dentro da faixa etária de 20 à 49 anos, mais de 65% das agressões foram praticadas pelos próprios companheiros das vítimas. A partir disto, a Justiça Restaurativa pode apresentar uma mudança no âmbito da violência doméstica, buscando resultados efetivos que a Justiça Retributiva não conseguiu atingir.
INTERRUPÇÃO DA GRAVIDEZ E INTERPRETAÇÃO CONSTITUCIONAL: ANÁLISE DA EVOLUÇÃO DA HERMENÊUTICA DA CORTE CONSTITUCIONAL BRASILEIRA ATÉ A ADPF Nº 442
Authors: Araújo Elita Isabella Morais Dorvillé de , Pimentel Elaine
Published: February 2025

Aborda a problemática da criminalização do aborto como mais uma forma de violência contra as mulheres no Brasil, problematizando como a hermenêutica constitucional do Supremo Tribunal Federal tem tratado a temática da interrupção da gravidez, por meio da análise feminista da jurisprudência nos casos da ADI 3510, da ADPF 54 e do HC 124.306, bem como a tese defendia pela ADPF nº 442, em tramitação no STF desde 2017, segundo a qual a tipificação do aborto no Brasil não foi recepcionada pela Constituição Federal de 1988.
O MONITORAMENTO PROCESSUAL COMO GARANTIA DA EFETIVIDADE DO ACESSO À JUSTIÇA NAS VARAS DO ÚNICO OFÍCIO DO TRIBUNAL DE JUSTIÇA DO ESTADO DE ALAGOAS
Authors: CESAR SHYMENA DE OLIVEIRA BARROS BRANDÃO , CESAR SHYMENA DE OLIVEIRA BARROS BRANDÃO , Tenório Marta Diana Lucindo
Published: February 2025

A efetividade do acesso à Justiça tem sido alvo de muitos debates no âmbito acadêmico, sobretudo, quando se trata da consagração do princípio processual da primazia da resolução do mérito em detrimento da primordialidade da forma há anos vivenciada no meio jurídico. Dada a necessidade de atender às inovações processuais e jurídicas, frente aos desafios do Poder Judiciário alagoano, faz-se mister a realização de um monitoramento processual que proporcione aos jurisdicionados uma tutela efetiva, justa e tempestiva, por meio do planejamento e acompanhamento processuais.
PROVA INDIRETA: DELIMITAÇÃO CONCEPTUAL E REQUISITOS (O DEVER DE ENUMERAÇÃO DOS FACTOS INDICIANTES E INDICIADOS E O DEVER DE MOTIVAÇÃO)
Authors: Sousa Susana Aires de
Published: February 2025

O artigo tem como objetivo delimitar conceptualmente a chamada prova indireta, decompondo-a nas suas categorias constitutivas de modo a expor a sua natureza e, consequentemente, as suas fragilidades. Como coordenadas fundamentais desse exame crítico segue princípios fundamentais do processo penal português. Atende-se ainda à apreciação que dela tem feito o Tribunal Constitucional português e o Tribunal Europeu dos Direitos do Homem (TEDH). Considera-se ainda o esforço jurisprudencial em desenvolver um conjunto de exigências à sua admissibilidade e valoração, de modo muito particular na jurisprudência espanhola e italiana. Como conclusão da investigação e reflexão defende-se ser por via dos deveres de fundamentação da sentença que a prova indireta de um facto desfavorável ao arguido conhece o seu derradeiro e inultrapassável limite.
MANDADO DE SEGURANÇA E A (IM)POSSIBILIDADE DE CONDENAÇÃO EM HONORÁRIOS SUCUMBENCIAIS COM O ADVENTO DO CÓDIGO DE PROCESSO CIVIL DE 2015
Authors: Aguiar Nathália de Araújo Oliveira de Oliveira
Published: February 2025

Com o advento do Código de Processo Civil de 2015, surgiu a discussão acerca da aplicabilidade ou não do dispositivo em referenteao julgamento de recursos interpostos em mandado de segurança (art. 85, §11). Apesar do dispositivo legal permitir a condenação em honorários de sucumbência recursal, a ação de mandado de segurança, regida por lei especial, possui vedação expressa à condenação em honorários no julgamento de 1ª instância. Assim, este trabalho analisa as duas correntes sobre o tema e conclui que a aplicação do §11º do art. 85 do CPC/2015 não é juridicamente viável, tendo em vista a vedação, por expressa disposição legal.
EFICÁCIA TEMPORAL DA REVOGAÇÃO DOS PRECEDENTES NO SUPREMO TRIBUNAL FEDERAL E NO SUPERIOR TRIBUNAL DE JUSTIÇA
Authors: Aguiar Caio César Maia , Aguiar Nathália de Araújo Oliveira de Oliveira
Published: February 2025

Os precedentes judiciais têm assumido especial relevância na resolução dos conflitos de interesses, principalmente diante do fenômeno da constitucionalização do Direito Processual. Essa tendência está clara no Código de Processo Civil que, mitigando preciosismos, prima pela resolução dos conflitos com efetivação da justiça social, exigindo uma jurisprudência estável e uniforme. Portanto, este estudo analisará a eficácia temporal da revogação dos precedentes judiciais no Supremo Tribunal Federal e no Superior Tribunal de Justiça que, nas posições de órgão máximo do Poder Judiciário e de última instância para causas infraconstitucionais, possuem a importante missão de concretizar a segurança jurídica esperada pela sociedade.