bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Learning in Plant Phenological Research: A Systematic Literature Review
Authors: Katal Negin , Rzanny Michael , Mäder Patrick , Wäldchen Jana
Published: March 2022

Climate change represents one of the most critical threats to biodiversity with far-reaching consequences for species interactions, the functioning of ecosystems, or the assembly of biotic communities. Plant phenology research has gained increasing attention as the timing of periodic events in plants is strongly affected by seasonal and interannual climate variation. Recent technological development allowed us to gather invaluable data at a variety of spatial and ecological scales. The feasibility of phenological monitoring today and in the future depends heavily on developing tools capable of efficiently analyzing these enormous amounts of data. Deep Neural Networks learn representations from data with impressive accuracy and lead to significant breakthroughs in, e.g., image processing. This article is the first systematic literature review aiming to thoroughly analyze all primary studies on deep learning approaches in plant phenology research. In a multi-stage process, we selected 24 peer-reviewed studies published in the last five years (2016–2021). After carefully analyzing these studies, we describe the applied methods categorized according to the studied phenological stages, vegetation type, spatial scale, data acquisition- and deep learning methods. Furthermore, we identify and discuss research trends and highlight promising future directions. We present a systematic overview of previously applied methods on different tasks that can guide this emerging complex research field.
Salinity Tolerance in a Synthetic Allotetraploid Wheat (SlSlAA) Is Similar to Its Higher Tolerant Parent Aegilops longissima (SlSl) and Linked to Flavonoids Metabolism
Authors: Fu Tiansi , Xu Chenyang , Li Hong , Wu Xiaohan , Tang Man , Xiao Binbin , Lv Ruili , Zhang Zhibin , Gao Xiang , Liu Bao , Yang Chunwu
Published: March 2022

Allotetraploidization between A and S (closely related to B) genome species led to the speciation of allotetraploid wheat (genome BBAA). However, the immediate metabolic outcomes and adaptive changes caused by the allotetraploidization event are poorly understood. Here, we investigated how allotetraploidization affected salinity tolerance using a synthetic allotetraploid wheat line (genome SlSlAA, labeled as 4x), its Aegilops longissima (genome SlSl, labeled as SlSl) and Triticum urartu (AA genome, labeled as AA) parents. We found that the degree of salinity tolerance of 4x was similar to its SlSl parent, and both were substantially more tolerant to salinity stress than AA. This suggests that the SlSl subgenome exerts a dominant effect for this trait in 4x. Compared with SlSl and 4x, the salinity-stressed AA plants did not accumulate a higher concentration of Na+ in leaves, but showed severe membrane peroxidation and accumulated a higher concentration of ROS (H2O2 and O2⋅⁣–) and a lesser concentration of flavonoids, indicating that ROS metabolism plays a key role in saline sensitivity. Exogenous flavonoid application to roots of AA plants significantly relieved salinity-caused injury. Our results suggest that the higher accumulation of flavonoids in SlSl may contribute to ROS scavenging and salinity tolerance, and these physiological properties were stably inherited by the nascent allotetraploid SlSlAA.
Mature Sunflower Inflorescences Face Geographical East to Maximize Absorbed Light Energy: Orientation of Helianthus annuus Heads Studied by Drone Photography
Authors: Takács Péter , Kovács Zoltán , Száz Dénes , Egri Ádám , Bernáth Balázs , Slíz-Balogh Judit , Nagy-Czirok Magdolna , Lengyel Zsigmond , Horváth Gábor
Published: March 2022

Mature sunflower (Helianthus annuus) inflorescences, which no longer follow the Sun, face the eastern celestial hemisphere. Whether they orient toward the azimuth of local sunrise or the geographical east? It was recently shown that they absorb maximum light energy if they face almost exactly the geographical east, and afternoons are usually cloudier than mornings. However, the exact average and standard deviation (SD) of the azimuth angle of the normal vector of mature sunflower inflorescences have never been measured on numerous individuals. It is imaginable that they prefer the direction of sunrise rather than that of the geographical east. To decide between these two photobiological possibilities, we photographed mature inflorescences of 14 sunflower plantations using a drone and determined the average and SD of the azimuth angle of the normal vector of 2,800 sunflower heads. We found that the average azimuth αinflorescence = 89.5° ± 42.8° (measured clockwise from the geographical north) of inflorescences practically coincided with the geographical eastern direction (αeast = 90°) instead of the azimuth of local sunrise αsunrise = 56.14° – 57.55°. Although the SD of the orientation of individual inflorescences was large (± 42.8°), our finding experimentally corroborated the earlier theoretical prediction that the energetically ideal azimuth of sunflower inflorescences is east, if mornings are usually less cloudy than afternoons, which is typical for the domestication region of H. annuus. However, the average orientation of inflorescences of two plantations in hilly landscapes more or less differed from that of the majority of plantations in plane landscapes. The reason for this deviation may be that the illumination conditions in hilly sites more or less differed from those in plane landscapes. Furthermore, in a plantation, we observed a group of south-facing inflorescences that were in shadow for about 5 h both after sunrise and before sunset. This southern orientation can be explained by the southern maximum of total light energy absorbed by the partly shadowed inflorescences during the day, as computed by our software integrating both the diffuse skylight and the direct sunlight received by sunflower inflorescences.
Genome Engineering Technology for Durable Disease Resistance: Recent Progress and Future Outlooks for Sustainable Agriculture
Authors: Ali Qurban , Yu Chenjie , Hussain Amjad , Ali Mohsin , Ahmar Sunny , Sohail Muhammad Aamir , Riaz Muhammad , Ashraf Muhammad Furqan , Abdalmegeed Dyaaaldin , Wang Xiukang , Imran Muhammad , Manghwar Hakim , Zhou Lei
Published: March 2022

Crop production worldwide is under pressure from multiple factors, including reductions in available arable land and sources of water, along with the emergence of new pathogens and development of resistance in pre-existing pathogens. In addition, the ever-growing world population has increased the demand for food, which is predicted to increase by more than 100% by 2050. To meet these needs, different techniques have been deployed to produce new cultivars with novel heritable mutations. Although traditional breeding continues to play a vital role in crop improvement, it typically involves long and laborious artificial planting over multiple generations. Recently, the application of innovative genome engineering techniques, particularly CRISPR-Cas9-based systems, has opened up new avenues that offer the prospects of sustainable farming in the modern agricultural industry. In addition, the emergence of novel editing systems has enabled the development of transgene-free non-genetically modified plants, which represent a suitable option for improving desired traits in a range of crop plants. To date, a number of disease-resistant crops have been produced using gene-editing tools, which can make a significant contribution to overcoming disease-related problems. Not only does this directly minimize yield losses but also reduces the reliance on pesticide application, thereby enhancing crop productivity that can meet the globally increasing demand for food. In this review, we describe recent progress in genome engineering techniques, particularly CRISPR-Cas9 systems, in development of disease-resistant crop plants. In addition, we describe the role of CRISPR-Cas9-mediated genome editing in sustainable agriculture.
Reference Dependence in Bayesian Reasoning: Value Selection Bias, Congruence Effects, and Response Prompt Sensitivity
Authors: Talboy Alaina , Schneider Sandra
Published: March 2022

This work examines the influence of reference dependence, including value selection bias and congruence effects, on diagnostic reasoning. Across two studies, we explored how dependence on the initial problem structure influences the ability to solve simplified precursors to the more traditional Bayesian reasoning problems. Analyses evaluated accuracy and types of response errors as a function of congruence between the problem presentation and question of interest, amount of information, need for computation, and individual differences in numerical abilities. Across all problem variations, there was consistent and strong evidence of a value selection bias in that incorrect responses almost always conformed to values that were provided in the problem rather than other errors including those related to computation. The most consistent and unexpected error across all conditions in the first experiment was that people were often more likely to utilize the superordinate value (N) as part of their solution rather than the anticipated reference class values. This resulted in a weakened effect of congruence, with relatively low accuracy even in congruent conditions, and a dominant response error of the superordinate value. Experiment 2 confirmed that the introduction of a new sample drew attention away from the provided reference class, increasing reliance on the overall sample size. This superordinate preference error, along with the benefit of repeating the PPV reference class within the question, demonstrated the importance of reference dependence based on the salience of information within the response prompt. Throughout, higher numerical skills were generally associated with higher accuracy, whether calculations were required or not.
Gradual Acquisition of Professional Knowledge, Audit Quality and Audit Fees
Authors: Xu Gaoshuang , Ding Rui , Cheng Hanxiu , Xing Qiuhang
Published: March 2022

The acquisition of professional knowledge is a core issue in the formation of auditor industry expertise; however, previous literature has neglected the time required for auditors to acquire professional knowledge. We examine the audit quality and fees of audit firms in different stages of an auditor acquiring professional knowledge and find that, in the initial stage of the process of knowledge acquisition, audit quality and audit fees decrease. However, in the long run, knowledge learning has a more obvious effect on the improvement of audit quality and audit fees. Specifically, knowledge learning has a positive effect on the development of audit firms.
Entrepreneurship Education and Health-Stress Analysis of College Teachers and Students Using Backpropagation Neural Network Model
Authors: Fu Leiming , Cheng Qi
Published: March 2022

The purpose is to solve the problem of college students’ employment difficulties. It is the development trend of the times to master the basic psychological pressure state of students and analyze students’ problems by using modern technology and science. First, based on Marxist theory, the theory of entrepreneurship education and the characteristics of teachers and students in colleges are expounded, and the principle and algorithms of Backpropagation Neural Network (BPNN) are introduced. Second, from the perspective of entrepreneurship education and mental health factors of college students, the sample set of the BPNN model is collected using a Questionnaire Survey (QS). Then, the sample set is normalized to analyze the current college entrepreneurship education and the health and stress of college students. The results show that the comprehensive BPNN output of entrepreneurship education is 0.726, indicating that entrepreneurship education in colleges is at a moderate level. The proposed BPNN model can perform better than the traditional prediction methods in predicting college students’ mental health, and the data fitting results are satisfactory. Overall, college students’ entrepreneurship education should be improved, and schools should take more incentives to help adjust college students’ mentality.
The Effect of Psychological Capital and Role Conflict on the Academic Entrepreneurial Intents of Chinese Teachers in Higher Education: A Study Based on the Theory of Planned Behavior
Authors: Liao Kai , Liu Ziyang , Li Bing
Published: March 2022

Because academic entrepreneurship is an innovation driving force in China’s economy, teachers are key knowledge creators in the process of entrepreneurship. Therefore, it is particularly important to give attention to the individual psychological mechanism factors at play in the process of teachers in higher education academic entrepreneurship. The purpose of this study is to identify individual psychological capital and role conflict issues among university teachers in China. To accomplish this aim, we investigated the emergence of positive academic entrepreneurial intents, continued through the process of academic entrepreneurship, and clarified the impact of psychological capital and role conflict on entrepreneurial intent. Based on the theory of planned behavior, we constructed a research model from the perspective of entrepreneurial intent prior to entrepreneurial action. We established a cohort of teachers in 17 higher education institutions (N = 525) in southern China, with psychological capital and role conflict as the prior independent variables and the teachers’ academic entrepreneurial intent as the dependent variable. Using quantitative analysis, SPSS 22.0, and AMOS 23.0, we conducted reliability and validity tests, correlation analysis, and structural equation models on the collected data. We reached the following conclusions: (1) psychological capital has a positive effect on attitudes toward academic entrepreneurship; (2) psychological capital has a positive effect on perceived behavioral control; (3) role conflict has a negative effect on perceived behavioral control; (4) academic entrepreneurial attitudes have a positive effect on academic entrepreneurial intent; (5) perceived behavioral control has a positive effect on academic entrepreneurial intent; (6) subjective norms have a positive effect on academic entrepreneurial intent. We also provide some suggestions about academic entrepreneurship for university administrators.
The Complex Dynamics of Resources and Maintaining Factors in Social Networks for Alcohol-Use Disorders: A Cross-Sectional Study
Authors: Braus Niels , Kewitz Sonja , Hunger-Schoppe Christina
Published: March 2022

Systemic therapy considers the complex dynamics of relational factors and resources contributing to psychological symptoms. Negative maintaining factors have been well researched for people suffering from Alcohol-use Disorders (AUD). However, we know little about the complex dynamics of these negative factors and resources. We interviewed fifty-five participants suffering or fully remitted from Alcohol-use disorders in this cross-sectional study (M = 52 years; 33% female). The interviews focused on relational factors (e.g., social support and social negativity) referring to a Support Social Network and a Craving Social Network (CSN). The CSN included all significant others who were associated with craving situations. We compared the network characteristics of the group suffering from Alcohol-use Disorders (n = 38) to a fully remitted control group (n = 17). The abstinent group with full remission named on average fewer individuals in the CSNs. They had lower social negativity mean scores in the Support Social Network compared to the non-remitted group (d = 0.74). In the CSN, the mean scores of social support were significantly higher than the median for both groups (d = 2.50). These findings reveal the complex interplay of relational patterns contributing to the etiology, maintenance, and recovery from Alcohol-use disorders. A successful recovery can be linked to increased social resources and reduced relations associated with craving. However, craving-associated relations represent an important source of social support. Future research should investigate this ambivalence for the systemic perspective on the explanation and treatment of Alcohol-use disorders.
COVID-19 Adaptive Interventions: Implications for Wellbeing and Quality-of-Life
Authors: Ramkissoon Haywantee
Published: March 2022

Social bonds may assist in cultivating a more positive attitude to life through commonly shared meanings about the COVID-19 pandemic. The key challenge, however, is how to foster social bonds meeting the changing demands in a post pandemic world. Yet, it is in the middle of a crisis that the conversation needs to start about how to strategically plan for the recovery. This is important not only in the current pandemic, but also in a post pandemic world. Reinforcing or fostering new social bonds is likely to bring positive experiences. The latter is central to human health and wellbeing, and has potential to contribute greatly in enhancing people’s quality of life. In an attempt to foster place social bonding in the COVID-19 pandemic and beyond to subsequently contribute to wellbeing, this paper develops and proposes a new conceptual framework suggesting the need for adaptive social bonding interventions in the SARS-CoV-2 pandemic. This is an essential measure to manage the significant impacts on our global health services due to a decline in people’s mental health in addition to COVID-19 physical impacts. The paper discusses how promoting adaptive social bonding interventions (psycho-socio, digital and nature social bonding) can make people more resilient. It further discusses how they can be empowered psychologically, socially, and emotionally in the current challenging times. The conceptual framework posits that social bonding interventions can assist in maintaining better mental, physical, emotional, and spiritual wellbeing and discusses how these wellbeing outcomes may also be experienced post the pandemic. This has important benefits and is of relevance to governments, policy makers and healthcare professionals in delivering better health care and equipping people with coping mechanisms both throughout the pandemic and in the long run.
Tracking Changes in Students’ Online Self-Regulated Learning Behaviors and Achievement Goals Using Trace Clustering and Process Mining
Authors: Taub Michelle , Banzon Allison M. , Zhang Tom , Chen Zhongzhou
Published: March 2022

Success in online and blended courses requires engaging in self-regulated learning (SRL), especially for challenging STEM disciplines, such as physics. This involves students planning how they will navigate course assignments and activities, setting goals for completion, monitoring their progress and content understanding, and reflecting on how they completed each assignment. Based on Winne & Hadwin’s COPES model, SRL is a series of events that temporally unfold during learning, impacted by changing internal and external factors, such as goal orientation and content difficulty. Thus, as goal orientation and content difficulty change throughout a course, so might students’ use of SRL processes. This paper studies how students’ SRL behavior and achievement goal orientation change over time in a large (N = 250) college introductory level physics course taught online. Students’ achievement goal orientation was measured by repeated administration of the achievement goals questionnaire-revised (AGQ-R). Students’ SRL behavior was measured by analyzing their clickstream event traces interacting with online learning modulesviaa combination of trace clustering and process mining. Event traces were first divided into groups similar in nature using agglomerative clustering, with similarity between traces determined based on a set of derived characteristics most reflective of students’ SRL processes. We then generated causal nets for each cluster of tracesviaprocess mining and interpreted the underlying behavior and strategy of each causal net according to the COPES SRL framework. We then measured the frequency at which students adopted each causal net and assessed whether the adoption of different causal nets was associated with responses to the AGQ-R. By repeating the analysis for three sets of online learning modules assigned at the beginning, middle, and end of the semester, we examined how the frequency of each causal net changed over time, and how the change correlated with changes to the AGQ-R responses. Results have implications for measuring the temporal nature of SRL during online learning, as well as the factors impacting the use of SRL processes in an online physics course. Results also provide guidance for developing online instructional materials that foster effective SRL for students with different motivational profiles.
Informal Safety Communication of Construction Workers: Conceptualization and Scale Development and Validation
Authors: Cong Weiyi , Xue Hong , Liang Huakang , Su Yikun , Zhang Shoujian
Published: March 2022

Existing studies have highlighted the importance of informal safety communication among workers at construction sites. However, there is still a lack of empirically tested theoretical models with valid and reliable scales for describing and measuring construction workers’ informal safety communication (CWISC). Accordingly, this study aimed to fill this need by developing an instrument to assess the communication performance of construction workers. Four stages of scale development were described: construct formation, item generation, factor extraction through the exploratory factor analysis (EFA) (n = 219), and scale assessment through the confirmatory factor analysis (CFA) (n = 156). Using questionnaire data drawn from construction workers in China, the CWISC was verified to be a three-dimensional construct including citizenship safety communication (CSC), self-needed safety communication (SSC), and participatory safety communication (PSC). The corresponding CWISC scale with 12 items was shown to have acceptable internal consistency reliability, as well as content, convergent, and discriminant validity. The CWISC scale could serve as an instrument to assess and identify the weaknesses in informal safety communication performance of construction workers. In turn, this information could help supervisors implement appropriate management practices to those workers to enhance workplace informal safety communication. Related studies taking a multidimensional CWISC into account were expected to be carried out.
Influence of Psychological Separation on Master Graduates’ Career Maturity: Mediating Role of Occupational Self-Efficacy
Authors: Jianchao Ni , Yumei Wang , Dongchen Li
Published: March 2022

This research adopts the career maturity as an indicator of one’s intention and ability in career development, and explores whether and how psychological separation from parents and occupational self-efficacy influence one’s career maturity. A structural equation model is constructed and tested with data from a survey of 584 master graduates in top universities across China. According to the study, it is founded that: (1) The psychological separation and occupational self-efficacy of master graduates are significantly and positively correlated with occupational self-efficacy, and career maturity, respectively. (2) Occupational self-efficacy plays a part of the mediating role between psychological separation and career maturity. (3) Master graduates with a high degree of psychological separation are more confident in achieving their career goals, more involved in the career selection process and have a higher level of career development. These findings will arouse the attention of the society to the master graduates’ career maturity to some extent.
Sensorimotor Synchronization in Healthy Aging and Neurocognitive Disorders
Authors: von Schnehen Andres , Hobeika Lise , Huvent-Grelle Dominique , Samson Séverine
Published: March 2022

Sensorimotor synchronization (SMS), the coordination of physical actions in time with a rhythmic sequence, is a skill that is necessary not only for keeping the beat when making music, but in a wide variety of interpersonal contexts. Being able to attend to temporal regularities in the environment is a prerequisite for event prediction, which lies at the heart of many cognitive and social operations. It is therefore of value to assess and potentially stimulate SMS abilities, particularly in aging and neurocognitive disorders (NCDs), to understand intra-individual communication in the later stages of life, and to devise effective music-based interventions. While a bulk of research exists about SMS and movement-based interventions in Parkinson’s disease, a lot less is known about other types of neurodegenerative disorders, such as Alzheimer’s disease, vascular dementia, or frontotemporal dementia. In this review, we outline the brain and cognitive mechanisms involved in SMS with auditory stimuli, and how they might be subject to change in healthy and pathological aging. Globally, SMS with isochronous sounds is a relatively well-preserved skill in old adulthood and in patients with NCDs. At the same time, natural tapping speed decreases with age. Furthermore, especially when synchronizing to sequences at slow tempi, regularity and precision might be lower in older adults, and even more so in people with NCDs, presumably due to the fact that this process relies on attention and working memory resources that depend on the prefrontal cortex and parietal areas. Finally, we point out that the effect of the severity and etiology of NCDs on sensorimotor abilities is still unclear: More research is needed with moderate and severe NCD, comparing different etiologies, and using complex auditory signals, such as music.
“Responsible” or “Strange?” Differences in Face Mask Attitudes and Use Between Chinese and Non-East Asian Canadians During COVID-19’s First Wave
Authors: Zhang Ying Shan Doris , Noels Kimberly A. , Young-Leslie Heather , Lou Nigel Mantou
Published: March 2022

Early in the COVID-19 pandemic, journalists and scholars noted differences between Asians and North Americans in their support for public mask use. These differences were primarily assumed to be due d to variations in ethnocultural norms and practices. To better ascertain people’s motives for wearing masks and potential cultural differences in these rationales, this comparative, mixed-methods research examines Chinese and non-East Asian Canadians’ mask use attitudes utilizing online group interviews (Study 1) and a nation-wide survey (Study 2) Study 1, conducted in the early stages of the pandemic, captured an ambivalent, yet evolving attitude toward public mask use among the non-East Asian Canadians, which differed from their Chinese counterparts who more uniformly perceived mask use favorably. Study 2, conducted 2 months later, suggests that both groups primarily wore masks for disease protection- and prevention-related reasons. However, age and education appeared to influence the mask wearing frequency of the non-East Asian Canadians, for whom public mask use was less prevalent and normative. The attitudinal differences in public mask use call for targeted strategies to support mask wearing for different ethnocultural groups, which may be achieved partially through enhancing interethnic understanding on the diversified use of and opinions about masks. The findings suggest that favorable social norms, along with evidence-based information campaigns involving personal appeals may encourage greater mask use by the non-East Asian population.
The interRAI Child and Youth Suite of Mental Health Assessment Instruments: An Integrated Approach to Mental Health Service Delivery
Authors: Stewart Shannon L. , Celebre Angela , Semovski Valbona , Hirdes John P. , Vadeboncoeur Chris , Poss Jeffrey W.
Published: March 2022

Various biological, social, psychological, and environmental factors impact children and youth living with mental health problems across their lifespan. To meet the wide-ranging challenges of mental illness, service system integration is needed to improve efficiencies and reduce fragmentation. Unfortunately, the mental health system has been plagued by the lack of coordination across services. There is a general consensus that mental health service delivery must ensure a child or youth’s needs are addressed in a collaborative, coordinated, and seamless manner. A key element to successful integration is the development of a comprehensive standardized screening and assessment system. Numerous assessments have been developed to assess child mental health and functioning, but they typically have a very narrow focus with limited use and utility. Not only does this reduce the ability to take a life course perspective to mental health, but this uncoordinated approach also results in redundancies in information collected, additional resources, and increased assessor burden for children, youth, and their families. The interRAI child and youth mental health assessment suite was developed in response to the need for an integrated mental health system for young persons. This suite includes screening and assessment instruments for in-patient and community settings, emergency departments, educational settings, and youth justice custodial facilities. The instruments form a mental health information system intentionally designed to work in an integrated fashion beginning in infancy, and incorporate key applications such as care planning, outcome measurement, resource allocation, and quality improvement. The design of these assessment tools and their psychometric properties are reviewed. Data is then presented using examples related to interpersonal trauma, illustrating the use and utility of the integrated suite, along with the various applications of these assessment systems.
L-Methylfolate in Antidepressant Non-responders: The Impact of Body Weight and Inflammation
Authors: Macaluso Matthew
Published: March 2022

This summary provides context for the role of L-methylfolate (LMF) in treating antidepressant non-responders. Bidirectional relationships have been observed between obesity and/or inflammation and depression. Studies have shown an increased prevalence of depression among patients with elevated body mass index and/or chronic inflammation and an increased risk of becoming obese and experiencing chronic inflammation in those with depression. These relationships can negatively affect the pathophysiology of depression. Elevated cytokine levels have been found to be among the factors that correlate with poor antidepressant treatment responsiveness. Low baseline neurotransmitter levels (e.g., serotonin) can also be associated with reduced effectiveness of commonly used antidepressants [e.g., selective serotonin reuptake inhibitors (SSRIs)]. LMF is an approved nutritional adjunctive antidepressant therapy that increases central neurotransmitter levels and thereby improves the effectiveness of antidepressant therapy. LMF can increase clinical response when used adjunctively in patients with major depressive disorder (MDD) and who are SSRI-resistant. In 2 randomized controlled trials, the pooled results showed increased response rates (32.3 vs. 14.6%; P = 0.04) as measured by a ≥50% reduction or final score ≤ 7 on the Hamilton Depression Rating Scale (HAM-D) and greater mean HAM-D reductions (−5.6 vs. −3.0; P = 0.05) when LMF was added to an SSRI compared with an SSRI plus placebo. Additionally, LMF has demonstrated effectiveness in real-world studies, with 67.9% of patients responding to therapy, using the 9-item Patient Health Questionnaire (P < 0.001). Post-hoc analyses found that patients with inflammation and/or obesity responded better to adjunctive LMF therapy compared with the overall sample (mean HAM-D reduction: −2.74 vs. +0.99).
The Effects of Patient Education on Psychological Status and Clinical Outcomes in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Authors: Wu Zugui , Zhu Yue , Wang Yi , Zhou Rui , Ye Xiangling , Chen Zehua , Li Congcong , Li Junyi , Ye Zixuan , Wang Zhenbang , Liu Wengang , Xu Xuemeng
Published: March 2022

Background

Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease. The disease has a serious impact on mental health and requires more effective non-pharmacological interventions.

Objective

This study aims to systematically evaluate the effectiveness of patient education on psychological status and clinical outcomes in rheumatoid arthritis.

Methods

This systematic review and meta-analysis was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Cochrane Library, EMBASE database, and Web of Science database were screened for articles published until November 2, 2021. Randomized controlled trials (RCTs) of patient education for RA were included. Outcomes measures included pain, physical function, disease activity, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anxiety, depression, Arthritis Self-Efficacy (pain, other symptoms, total), and General health. For each outcome, standardized mean differences or mean differences and 95% confidence intervals (CIs) were calculated.

Results

A total of 24 RCTs (n= 2,276) were included according to the inclusion and exclusion criteria. Meta-analysis revealed a statistically significant overall effect in favor of patient education for physical function [SMD = −0.52, 95% CI (−0.96, −0.08),I2= 93%,P= 0.02], disease activity [SMD = −1.97, 95% CI (−3.24, −0.71),I2= 97%,P= 0.002], ASE (pain) [SMD = −1.24, 95% CI (−2.05, −0.43),I2= 95%,P= 0.003], ASE (other symptoms) [SMD = −0.25, 95% CI (−0.41, −0.09),I2= 25%,P= 0.002], ASE (total) [SMD = −0.67, 95% CI (−1.30, −0.05),I2= 90%,P= 0.03], and general health [SMD = −1.11, 95% CI (−1.36, −0.86),I2= 96%, P < 0.00001]. No effects were found for anxiety [SMD = 0.17, 95% CI (−0.64, 0.98),I2= 82%,P= 0.68], depression [SMD = −0.18, 95% CI (−0.52, 0.15),I2= 52%,P= 0.28], pain [SMD = −0.37, 95% CI (−0.80, 0.05),I2= 89%,P= 0.08], and CRP [SMD = −0.27, 95% CI (−0.57, 0.02),I2= 0%,P= 0.07].

Conclusions

Patient education may be effective in improving clinical outcomes and psychological status in patients with rheumatoid arthritis. Considering the methodological limitations of the included RCTs, more high-quality and large-sample RCTs are needed to confirm this conclusion in the future.

Systematic Review Registration

http://www.crd.york.ac.uk/prospero, identifier: CRD42021250607.
Risk Assessment and Management for Potential Living Kidney Donors: The Role of “Third-Party” Commission
Authors: Tattoli Lucia , Santovito Davide , Raciti Ida Marina , Scarmozzino Antonio , Di Vella Giancarlo
Published: March 2022

Living kidney donation is the most common type of living-donor transplant. Italian guidelines allow the living donations from emotionally related donors only after clear and voluntary consent expressed by both the donor and the recipient involved. Living donation raises ethical and legal issues because donors voluntarily undergo a surgical procedure to remove a healthy kidney in order to help another person. According to the Italian standards, the assessment of living donor-recipient pair has to be conducted by a medical “third party”, completely independent from both the patients involved and the medical team treating the recipient. Starting from the Hospital “Città della Salute e della Scienza” of Turin (Italy) experience, including 116 living kidney donations, the Authors divided the evaluation process performed by the “Third-Party” Commission into four stages, with a particular attention to the potential donor. Living donation procedures should reflect fiduciary duties that healthcare providers have toward their patients, originating from the relationship of trust between physician and patient. In addition to that, the social implications are enormous if one considers the worldwide campaigns to promote public awareness about organ donation and transplantation, and to encourage people to register their organ donation decisions. The systematic process proposed here can be a tool that proactively reduces and controls the risks of coercion, organ trafficking, vitiated consent, insufficient weighting of donative choice, that could arise especially in donors involved in living kidney donation.
Risk Factors Identification of Unsafe Acts in Deep Coal Mine Workers Based on Grounded Theory and HFACS
Authors: Yang Li , Wang Xue , Zhu Junqi , Qin Zhiyuan
Published: March 2022

The risk factors affecting workers' unsafe acts were comprehensively identified by Human Factors Analysis and Classification System (HFACS) and grounded theory based on interview data and accident reports from deep coal mines. Firstly, we collected accident case and field interview data from deep coal mines issued by authoritative institutions. Then, the data were coded according to grounded theory to obtain relevant concepts and types. The HFACS model was used to classify the concepts and categories. Finally, the relationship between core and secondary categories was sorted out by applying a story plot. The results show that risk factors of unsafe acts of deep coal mine workers include environmental factors, organizational influence, unsafe supervision and unsafe state of miners, and the main manifestations of unsafe acts are errors and violations. Among them, the unsafe state of miners is the intermediate variable, and other factors indirectly affect risky actions of coal miners through unsafe sates. Resource management, organizational processes and failure to correct problems are the top three risk factors that occur more frequently in unsafe acts. The three most common types of unsafe act are unreasonable labor organization, failure to enforce rules, and inadequate technical specifications. By combining grounded theory and the HFACS framework to analyze data, risk factors for deep coal miners can be quickly identified, and more precise and comprehensive conceptual models of risk factors in unsafe acts of deep coal miners can be obtained.
Climatology of Lake-Effect Snow Days Along the Southern Shore of Lake Michigan: What Is the Sensitivity to Environmental Factors and Snowband Morphology?
Authors: Clark Craig A. , Metz Nicholas D. , Goebbert Kevin H. , Ganesh-Babu Bharath , Ballard Nolan , Blackford Andrew , Bottom Andrew , Britt Catherine , Carmer Kelly , Davis Quenten , Dufort Jilliann , Gendusa Anna , Gertonson Skylar , Harms Blake , Kavanaugh Matthew , Landgrebe Jeremy , Mazan Emily , Schroeder Hannah , Rutkowski Nicholas , Yurk Caleb
Published: March 2022

The Laurentian Great Lakes have substantial influences on regional climatology, particularly with impactful lake-effect snow events. This study examines the snowfall, cloud-inferred snow band morphology, and environment of lake-effect snow days along the southern shore of Lake Michigan for the 1997–2017 period. Suitable days for study were identified based on the presence of lake-effect clouds assessed in a previous study and extended through 2017, combined with an independent classification of likely lake-effect snow days based on independent snowfall data and weather map assessments. The primary goals are to identify lake-effect snow days and evaluate the snowfall distribution and modes of variability, the sensitivity to thermodynamic and flow characteristics within the upstream sounding at Green Bay, WI, and the influences of snowband morphology. Over 300 lake-effect days are identified during the study period, with peak mean snowfall within the lake belt extending from southwest Michigan to northern Indiana. Although multiple lake-effect morphological types are often observed on the same day, the most common snow band morphology is wind parallel bands. Relative to days with wind parallel bands, the shoreline band morphology is more common with a reduced lower-tropospheric zonal wind component within the upstream sounding at Green Bay, WI, as well as higher sea-level pressure and 500-hPa geopotential height anomalies to the north of the Great Lakes. Snowfall is sensitive to band morphology, with higher snowfall for shoreline band structures than for wind parallel bands, especially due south of Lake Michigan. Snowfall is also sensitive to thermodynamic and flow properties, with a greater sensitivity to temperature in southwest Michigan and to flow properties in northwest Indiana.
The Impact of COVID-19 Surges in 2019–2021 on Patient-Reported Outcome Measures After Spine Surgery at an Academic Tertiary Referral Center in Taiwan: A Retrospective Observational Cohort Study
Authors: Lin Yu-Hsien , Wang Jun-Sing , Wang Wen-Chien , Lin Yu-Tsung , Wu Yun-Che , Chen Kun-Hui , Pan Chien-Chou , Chin Ning-Chien , Shih Cheng-Min , Lee Cheng-Hung
Published: March 2022

Aim

Limited data are available on the impact of the coronavirus disease 2019 (COVID-19) pandemic on patient-reported outcome measures (PROMs) in patients who underwent spine surgery. In this study, we aimed to investigate the associations between the COVID-19 outbreak in Taiwan (May 2021) and PROMs in patients who underwent spine surgery.

Method

We retrospectively identified patients who underwent spine surgery during identical defined 6-week time-intervals (May 16 to June 30) in 2019, 2020, and 2021. PROMs, including visual analog scale (VAS) score for pain, Oswestry disability index (ODI), and EuroQol-5D (EQ-5D), were investigated before surgical intervention and at a 1-month follow-up. Relevant clinical information was collected from the electronic medical records of patients. Linear regression analysis was used to examine the association between the pandemic in 2021 (vs. 2019/2020) and the PROMs after adjusting for age, sex, and relevant clinical variables.

Results

The number of patients who underwent spine surgery at our hospital during the identical defined 6-week time-intervals in 2019, 2020, and 2021 was 77, 70, and 48, respectively. The surgical intervention significantly improved VAS, ODI, and EQ-5D of the patients (1 month after surgery vs. before surgery, all p < 0.001) in all three study periods. However, there was a significant between-group difference in change from baseline in VAS (p = 0.002) and EQ-5D (p = 0.010). The decrease in VAS and increase in EQ-5D after surgery in 2021 were not as much as those in 2019 and 2020. The associations between the pandemic in 2021 (vs. 2019/2020) and changes in VAS (β coefficient 1.239; 95% confidence interval [CI] 0.355 to 2.124; p = 0.006) and EQ-5D (β coefficient, −0.095; 95% CI, −0.155 to −0.035; p = 0.002) after spine surgery were independent of relevant clinical factors.

Conclusion

There was less improvement in short-term PROMs (VAS and EQ-5D) after spine surgery during the COVID-19 pandemic. Assessment of PROMs in surgical patients during a pandemic may be clinically relevant, and psychological support in this condition might help improve patients' outcomes.
The Mechanism of Downregulation of Twist1 Inhibiting Trophoblast Invasion and Aggravating the Development of Preeclampsia
Authors: Yang Shuangjian , Tong Wenjuan , Li Yi
Published: March 2022

To study the expression of under expressed transcription factor Twist1 in preeclampsia (PE) and its effect on the invasion of placental trophoblast cells and to explore its related mechanism on the development of PE by establishing a pregnant rat model. Methods: the villi were collected from the induced abortion in the first trimester (6–8 weeks), the normal placenta (18–20 weeks) induced by the second trimester, the term placenta tissue of normal pregnancy (37–40 weeks), and the placental tissue of patients with PE, to detect the expression of Twist1. Trophoblast cells were subjected to primary culture in placental tissues of normal pregnant women and placental tissues of PE patients. The invasion ability of the two groups of trophoblasts was detected, and the primary cultured trophoblasts were divided into two groups: an experimental group and a control group. Specific Twist1 siRNA was added to the experimental group, and no reagents were added to the control group. The above-mentioned cells were given different interventions. To explore the effect of Twist1 on trophoblast cell invasion, cells were cultivated for 72 h. The SD rats were conceived. After the pregnancy was stable, the SD rats in different groups were treated with different treatments (interference with Twist1), and the average systolic blood pressure and urine protein of the gestational mothers in the different treatment groups were measured at 1 week, 2 weeks, and full-term pregnancy. The expression of Twist1 in the placenta tissue of SD rats with different interventions at full-term pregnancy was detected. The results showed that Twist1 expression is down-regulated in PE, and the invasion ability of placental trophoblast cells in PE patients is weak. After inhibiting Twist1, the mean tail artery pressure and urine protein level of SD pregnant rats increase, showing a trend of PE. The mechanism may be related to the inhibition of the placenta by Twist1 Trophoblast cell invasion.
Acromegaliás páciens teljes foghiányának ellátása részlegesen egyéni értékű artikulátorban készült teljes lemezes fogpótlással
Authors: Somogyi Andrea , Hermann Péter , Kivovics Péter
Published: March 2022

Az acromegalia súlyos szisztémás kórkép, melynek hátterében a megnövekedett növekedési hormon (GH), valamintaz IGF-1 termelődése áll. A betegség klinikai manifesztációi között szerepel az aránytalan szkeletális növekedés, lágyszöveti szaporulat, metabolikus, kardiovaszkuláris és légzőrendszeri komorbiditások. A diagnózis felállítása hosszú évtizedekbe is telhet, köszönhetően a megjelenésbeli elváltozások lassú kialakulásának. Esetbemutatásunkban egy acromegaliában szenvedő páciens teljes szájüregi rehabilitációját mutatjuk be. A kezelés során az implantáció lehetősége a számos szisztémás megbetegedés miatt kontraindikált volt, így a páciensnek hagyományos teljes lemezes fogpótlás készült, részlegesen egyéni értékű artikulátorban. A páciens jelentős állcsontméretbeli eltérése, valamint számos szisztémás megbetegedése tette a kezelést szakmailag izgalmassá.
Statikus navigáció segítségével beültetett implantátumokon elhorgonyzott, felső egész fogívre kiterjedő rögzített fogpótlás és alsó kombinált fogpótlás készítése
Authors: Seereiner Tamás , Kivovics Márton
Published: March 2022

A protetikai szemléletű tervezés során a beültetendő fogászati implantátumok helyzetét és számát a készülő fogpótlás fajtája, az elhorgonyzás és a megtámasztás módja határozza meg. A navigált implantáció módszerével az előre megtervezett implantátum pozíciók nagy pontossággal reprodukálhatóak a műtét során. Statikus navigáció esetén az implantátum-ágy kialakításakor műszereinket sablon vezeti a kívánt pozícióba. A módszer csökkenti a posztoperatív morbiditást és a műtéti időt, melynek kiemelt jelentősége van az időskorúak fogászati ellátásában. Az így tervezett és kivitelezett implantációs fogpótlás hozzájárul az orális rehabilitáció esztétikájához és funkciójához, biztosítja a fogpótlás és az implantátumok megfelelő biomechanikai terhelését, valamint az implantátum körüli kemény- és lágyszövetek hosszú távú stabilitását. Esetbemutatásunkban összefoglaljuk a statikus navigáció segítségével beültetett implantátumokon elhorgonyzott felső egész fogívre kiterjedő rögzített fogpótlás és alsó kombinált fogpótlás készítésének menetét.