bluuebunny/crossref_metadata_2025 huggingface dataset:
Boris Ilyich Alperovich (to the 80th birthday)
Authors: Article Editorial
Published: April 2021

Creative biography of the known Russian surgeon and scientist - doctor of medical sciences, Honoured Physician of Russia, Honoured Science
Worker of Russia, State Prize Winner of RF, Honourary Citizen of Tomsk , professor B.I. Alperovich is presented in the article
Clinical aspects of living related liver grafts harvesting
Authors: Gautier S. V. , Kim E. F. , Tsiroulnikova O. M. , Khizroev Kh. M. , Ammosov A. A. , Khovrin V. V. , Kryzhanovskaya Ye. Yu.
Published: April 2021

Seven years experience of liver resection in living related donors for orthotopic transplantation in patients with end-stages diffuse and focal diseases of the liver is summarized. Basic principles of donor selection, surgical technique and postoperative course were studied in 104 cases of right and left liver graft harvesting. The postoperative incidence consisted of hemorrhage - 1 (1,1%), hernia - 1 (1,1%), bile leakage - 3 (3,3%). All donors survived with full medical and social rehabilitation.
Shape-memory implants in abdominal surgery
Authors: Dambayev G. Ts. , Gyunter V. E. , Soloviyov M. M. , Latypov V. R. , Fatyushina O. A. , Dambayeva Ye. G. , Avdoshina Ye. A. , Sharayevsk M. A.
Published: April 2021

Here are represented our results according to making and clinical using of different TiNi devices for treatment of digestive system diseases. Constructions for perfoming of compression anastomoses, cliping of tubular structures during laparoscopic operations and perforated ulcer plastic. Materials of experimental investigations and clinic experience of 220 cases treatment are represented.
Diagnosis and correction of disorders of blood aggregate statesin children with burning injury
Authors: Bocharov R. V. , Bocharova M. N. , Solnyshko A. L. , Udut V. V.
Published: April 2021

To reveal the character and dynamics of changes in the aggregate state of blood in children with burning injury and to choose the correction method, 200 children in burn shock were investigated. Hemostasis abnormalities were studied with aт ARP-01 analyzer (Mednord, Tomsk). A tactics for anticoagulation therapy has been chosen. A positive effect was observed from combination of programmed hypocoagulation and the method of reinfusion of autocellular mass after its antibiotic incubation
Prediction of bronchial permeability disturbance from breathing patterns
Authors: Karzilov A. I. , Tetenev F. F. , Bodrova T. N. , Mes’ko P. Ye.
Published: April 2021

Health subjects (n= 15), patients with bronchial asthma (n= 30), COPD (n= 16), and community-acquired pneumonia (n= 17) have been inspected in the mixed group (40 men, 38 women, 15-64 years old). The results of research of breathing patterns with interruption of air stream have been used to construct Raw, FEV1, FEV1% and FEV1/FVC% mathematical models. High diagnostic importance of FEV1% and FEV1/FVC% models in prediction of bronchial permeability disturbance has been shown.
Estimation of carotinoid, antioxidant, and oxidant statusby biophotonic scanning in healthy and sick persons with risk factorsof atherosclerosis
Authors: Kim V. N. , Krivulina G. V. , Shevelyev V. M. , Suslova T. Ye. , Gruzdeva O. V. , Karpov R. S.
Published: April 2021

High accuracy of biophotonic scanning in estimation of skin carotinoid score (SCS) and antioxidant status after 8-week period of correction by LifePak, MarineOmega, and Tegreen97 active dietary supplements is proved in 45 healthy persons with cardiovascular risks and in patients with cardiovascular diseases. SCS increased by 42.8% (p = 0.005) and total antioxidant capacity of blood (TAC) increased by 36.4% (p = 0.005) in health people; while in patients SCS increased by 47.4% (p = 0.001) and TAC increased by 30.3% (p = 0.008). The SCS accuracy in estimation of antioxidant status was 87%.
Physiological separation of erythrocytes in aortic arch
Authors: Medvedev M. A. , Koval G. S. , Ryazantseva N. V.
Published: April 2021

The erythrocyte distribution at the level of aortic arch is determined experimentally from structural-functional features. It is shown that there exists the mechanism of physiological separation of erythrocytes, which causes the prevalent income of younger and functionally valid forms of erythrocytes to brain and favors better oxygen supply of nerve cells.
Correction of hepatobiliary pathology by the complex herbal remedy
Authors: Chuchalin V. S. , Teplyakova Ye. M.
Published: April 2021

The influence of complex herbal remedy on the secretary and metabolic functions of a liver was investigated in rates with experimental toxic hepatitis and hypercholesterolemia. The result obtained have shown that complex herbal remedy shortened the time of evolution and decreased hepatic enzymes (AST, ALT, and GGT), alkaline phosphates, total bilirubin, and cholesterol. It has also been shown that complex herbal remedy increased the protein synthesis of hepatocyte and hampered lipolysis processes. On the other hand, the active components of this remedy regulated the excessive bile production. During complex herbal remedy administration, the rheologycal properties of bile are normalized, bile acid pool extends, and total cholesterol in bile reduces. Along with hepatoprotective properties, remedy has the expressive choleretic and cholekinetic effects.
New methods of investigation of the external base of skull at fatal injuries inpassenger compartment
Authors: Shadymov A. B. , Novosyolov A. S.
Published: April 2021

Basal skull fractures are frequent and cause certain difficulties in detection of the mechanism of their formation. Common dissecting methods do not allow detailed study of the external base of skull and deform facial soft tissues. A new method is developed, which allows determining the mechanism of formation of constructional fractures of the basal skull and pterygoid processes at various injuries, in particular, inside a passenger compartment at headon collision of motor vehicles. The method is registered as an invention.
Quality of life in patients with non-Hodgkin’s malignant lymphomas
Authors: Pospelova T. I. , Gritsai L. N. , Loseva M. I. , Maslova L. M. , Nechunayeva I. N.
Published: April 2021

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Vitamin-enriched drinks and dessert for myotoniс dystrophy patients with oropharyngeal dysfagia
Authors: Shnaider N. A. , Bakhtina Ye. A. , Kamoza T. L. , Kozulina Ye. A.
Published: April 2021

Myotonic dystrophy is a multisystemic disease which mutation may influence your development and function of different organs and tissue: smooth and skeletal-muscular tissue; heart; organs of the eye, brain. This review gives a simple information about balanced diet of patients myotonic dystrophy with oropharyngeal dysphagia.
The efficiency of millimeter-wave resonance therapy in cytotoxic supression of hemopoiesis
Authors: Kareva N. P. , Pospelova T. I. , Pozdnyakova S. V. , Ushakova G. Yu. , Shamayeva G. V.
Published: April 2021

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Myc-family oncogenes as therapeutic targets
Authors: Kabilova T. O. , Chernolovskaya Ye. L.
Published: April 2021

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Nutritive status in patients with lymphomas
Authors: Pospelova T. I. , Panin L. Ye. , Ivanchei O. S. , Nechounayeva I. N. , Shamayeva G. V. , Chernyavsky D. B.
Published: April 2021

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Vascular-thrombocyte disorders and genetic polymorphism of haemostatic system in hemophilia patients
Authors: Buyevich Ye. I. , Kotovschikova Ye. F. , Bogdanova I. V.
Published: April 2021

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Apoptosis cells in patients with multiple sclerosis
Authors: Vostryakova S. A. , Alifirova V. M. , Ivanova S. A. , Orlova Yu. Yu.
Published: April 2021

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Apoptosis and mechanisms of tumoral progression non-Hodgkin’s malignant lymphomas
Authors: Kovynev I. B. , Pospelova T. I. , Ageyeva T. A. , Diyachcova N. V. , Scvortsova N. V. , Voropayeva Ye. N. , Berezina O. V. , Nechounayeva I. N. , Lyamkina A. S.
Published: April 2021

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Peculiarity of bioelectric brain activity in children with tic disorders
Authors: Fedoseeva I. F. , Poponnikova T. V. , Galiyeva G. Yu.
Published: April 2021

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Comparative analysis of retrospective and current evaluation of life quality for patients with inhibitor form of hemophilia treated with Novoseven medication
Authors: Zozulya N. I. , Arina G. A.
Published: April 2021

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Modern therapy and prognostic factors at chronic lymphoid leucosis. Review of literature and own datas
Authors: Stadnik Ye. A. , Nikiteen Ye. A. , Alekseyeva Yu. A. , Salogub G. N. , Yakubovich M. A. , Virts Yu. V. , Zaritsky A. Yu.
Published: April 2021

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Opportunities of early laboratory diagnostics of tick-born neuroinfections: tick-borne encephalitis and Lyme borreliosis
Authors: Mar’ina N. M. , Shetekauri S. A. , Olchovsky I. A.
Published: April 2021

Diagnostics of tick-borne encephalitis and Lyme borreliosis is possible only by laboratory confirmation. The purpose of the investigation was the study of possibilities of immunoferment analysis and polymerase chain reaction for early diagnostics of these infections. It was revealed that mixinfection of patient does not influence on revelation of infectious agent by immunoferment analysis and polymerase chain reaction in the early period of disease. For initial diagnostics of focal and meningeal forms of tick-born neuroinfections, revelation IgM in blood serum is the most informative. The investigation of patient liquor by the method of polymerase chain reaction is the most available for diagnostics of early neuroborreliosis. The combination of methods (immunoferment analysis and polymerase chain reaction) increases the effectiveness of early laboratory diagnostics of focal and meningeal forms of tick-born encephalitis and Lyme borreliosis.
Mechanisms of development, value and contemporary possibility of correction of the anaemia at non-Hodgkin’s lymphomas
Authors: Lyamkina A. S. , Pospelova T. I. , Loseva M. I. , Kovynev I. B. , Nechounayeva I. N. , Diyachkova N. Yu.
Published: April 2021

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Clinical-immunological markers of generalized infections in newborns as functions of maturity of an organism
Authors: Maksutova A. K. , Belousova T. V. , Samsonova Ye. N. , Trunov A. N.
Published: April 2021

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Achievements in diagnostics and treatment of the patients with mieloid leucosis in Russian Federation
Authors: Turkina G. A. , Vinogradova O. Yu. , Khoroshko N. D. , Vorob’yov A. I.
Published: April 2021

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Autologous bone marrow-derived cell transplantation in the treatment of cerebral stroke
Authors: Krivoshapkin A. L. , Chernykh Ye. R. , Netesov Ye. V. , Leplina O. Yu. , Shevela Ye. Ya. , Kulagin A. D. , Lisukov I. A. , Ostanin A. A. , Kozlov V. A.
Published: April 2021

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Comparative analysis of the application results of high-intensive
laser radiation and high-frequency electrocautery for the laparoscopic surgery
of stomach
Authors: Pryakhin A. N.
Published: April 2021

The comparative analysis of the application of diode laser (970 nm wavelength) and high-frequency electrocautery for laparoscopic stomach
surgery was carried out. 30 experimental operations in dogs and 108 laparoscopic surgical interventions in clinic (fundoplication, vagotomy, pyloroplasty)
were performed. Laser application allowed to reduce the thermal injury of tissues, avoid complications, decrease hospitalization period
after operation from (3,4 ± 1,3) to (2,3 ± 0,6) days.
Difficult (for diagnosis) case of old posttraumatic diaphragmatic hernia
Authors: Klinovitsky I. Yu. , Brazhnikova N. A. , Maryina M. Ye.
Published: April 2021

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Состояние периферического звена эритрона при дисплазии соединительной ткани у детей
Authors: Ponomaryova D. A.
Published: April 2021

Status of peripheral blood erythrocytes was studied in 51 children aged 8 to 12 years with connective tissue dysplasia (CTD). There were re vealed
modifications superficial architectonics of red cells, decreased thiol groups and lipoprotein complex, increased content of diene conjugates
and antioxidant activity. Structural and metabolic abnormalities of peripheral blood erythrocytes in 13% children with CTD were accompanied by
anemia.
Metabolic syndrome in general medical practice
Authors: Kravets Ye. B. , Samoilova Yu. G. , Matyusheva N. B. , Bulanova A. A. , Dorokhova V. V. , Yadmaa O.
Published: April 2021

Modern scientific and practical information on urgency, prevalence, etiopathogenesis, clinical implications, laboratory diagnostics, and treatment of metabolic syndrome is presented. The paper presents up-to-date information on metabolic syndrome for general practice doctors and doctors of specialized services in order to improve efficiency of treatment of the discussed category of patients.
Clinical variants of the Helicobacter pylori-associated peptic ulcerin comparison to structural and functional changes in gastric mucosa
Authors: Shakurova N. R. , Roslyakova Ye. P. , Hvaschevsky A. I. , Poltoratsky A. N. , Afrikantova Ye. G.
Published: April 2021

The purpose of research was to compare cellular structure inflammatory in a gastric and a duodenal mucosa, its ratio with disregenerations at peptic ulcers of not complicated current and complicated with a bleeding, punching and its ratio with disregenerations at one peptic ulcers or plural peptic ulcers. At ulcer peptic complicated with a bleeding or punching observed more intensive character of an inflammation, a high level infiltration gastric mucosa and neutrophils, eosinophils. The density neutrophils and eosinophils infiltration correlated with disregenerations changes of gastric and a duodenal mucosa. The patients with 2 or more peptic ulcers have a high level infiltration gastric mucosa of neutrophils, plasmacytes and a high level infiltration duodenal mucosa of interepitelial neutrophils. The density neutrophils and interepitelial infiltration correlated with disregenerations changes of gastric and a duodenal mucosa.
Modern tendencies in a thyroid volume of the newly born childrenin Tomsk and Tomsk Region
Authors: Davydova T. V. , Kravets E. B.
Published: April 2021

The thyroid was ultrasonographically studied in 236 a newly born child aged 7-28 days of life in Tomsk and Tomsk Region. The sizes of thyroid lobes and its echogenicity were defermined. The infants were born by apparently healthy mothers and females, who took different dozes of iodine. A procedure for neonatal ultrasound study was developed. While data statistical processing individual dizes of ultrasonographical standard of a thyroid volume, which allows some patological conditions of the thyroid to be established at early stages of life were defesmined.
State of antioxidant blood system at physiological pregnancy and pregnancy complicated with bleeding
Authors: Mikashinowich Z. I. , Olempieva Ye. V.
Published: April 2021

The task of our investigation was the analysis of enzyme activity of antioxidant defense in women blood at physiological pregnancy and pregnancy complicated with hypertension. It was established that hyper production of hydrogen peroxide and glutathione peroxidase activation at physiological pregnancy improved microcirculation due to vasodilatation effect of hydrogen peroxide. It was established that activation of superoxiddysmutase and myeloperoxidase at pregnancy complicated with hypertension developed endothelial dysfunction owing to citotoxic effects of hydrogen peroxide.
Average duration of a forthcoming life as the integrated demographic indicatorand a method of an estimation of a state of health of the population
Authors: Mendrina G. I. , Oleynichenko V. F.
Published: April 2021

Both in the Russian Federation and in Tomsk area comes to light negative tendencies in population health: low level of indicator ADFL and the tendency of its decrease, lower level of an indicator at men, than at women. Only hardly more than half of men born in 2003 can live till 65 years, and women more than half till 80 years IADFL countrymen considerably below city, there are no bases for optimistic forecast IADFL for men.
Mistic and spiritual symbol of the Siberian State MedicalUniversity. Part 3
Authors: Tetenev F. F. , Karzilov A. I.
Published: April 2021

The history of the creation of Siberian State Medical University symbol — octahedral tower of faculty clinics — has been presented.
Ultrastructural and morphometrical peculiarities of embryo and fetus brainsynaptogenesis under conditions of prenatal ethanol exposure
Authors: Solonsky A. V. , Logvinov S. V.
Published: April 2021

The method of electron microscopy and morphometry have been used to study peculiarities in formation of the structure of human embryo and fetus brain synapses at early stages (7 to 12 weeks) of development at mother alcoholization. Electron microscopy of material obtained from alcoholic women has shown slowing-down of formation of synaptic structure. Morphometry has revealed that under the influence of prenatal alco holization the formation of components of synaptic brain contacts slows down at 9—12 th weeks of development: the area of presynaptic terminals and their perimeter decreases, and the perimeter of postsynaptic densities decreases as well.
Experimental-clinical substantiation of principles of treatment ulcergastroduodenal bleedings at elderly and senile age
Authors: Skochilova O. Ye.
Published: April 2021

Язвенные гастродуоденальные кровотечения, пожилой и старческий возраст, эндотоксемия
Influence of cerebral circulation disorders on the course of female climacteric period
Authors: Lyubarova I. B. , Tikhonovskaya O. A. , Alifirova V. M.
Published: April 2021

A comparative analysis of the premenopause and postmenopause course was carried out in women with cerebral circulation ischemic disor ders (group I) and in women without the signs of the cerebral vascular impairment (group II). The study included the evaluation of the anamnesis, objective status, functional state of the vegetative nervous system, asthenia as well as laboratory and instrumental examination methods. The analysis of the obtained data showed that cerebral circulation ischemic disorders in women contribute to earlier manifestations of the climacteric syndrome with a marked clinical picture presented by neurovegetative, metabolicendocrine and psychoemotional disorders as well as high fre quency of asthenic disturbances of predominantly hypostenic type.
Energy metabolism regulators effect on clinical course and inflammatory markers in patients with exacerbation of severe copd
Authors: Sanzharovskaya M. S. , Varvyanskaya N. V. , Yamkina N. S. , Pechyorkina I. N. , Smotrova A. A. , Antipov S. I. , Roslyakova Ye. P. , Akbasheva O. Ye. , Sanzharovskaya O. P. , Khazanov V. A. , Chernogoryuk G. E.
Published: April 2021

We assessed in a prospective, randomised, placebo-controlled trial the effects of «yantar-antitox» in patients with exacerbations of COPD requiring hospital admission. We recruited patients with exacerbations of severe COPD who were randomly assigned oral «Yantar-antitox» (n=33) or identical placebo (n=45) for 14 days, in addition to standard treatment with nebulised bronchodilators, antibiotics, and oxygen. We did spirometry and recorded symptom scores in inpatients. The 6-min walking distance (6MWD) was also determined. Inflammatory markers were measured in induced sputum and serum. Significant increase in the percentage predicted lung vital capacity, maximal expiratory flow volume, 6MWD were found between the patient in the «Yantar-antitox» — treated group.
Effect of Simvastatin on the spectrum of blood plasma fat acids change in the patients with ischemia heart disease
Authors: Novitsky V. V. , Karpov R. S. , Kotlovsky M. Yu. , Klemenkov S. V. , Voronkova O. V. , Shulman V. A. , Nikulina S. Yu. , Mashkovskaya S. V. , Kirichenko D. A. , Ivtchenko Ye. N. , Masterova A. A. , Zlodeyev K. V. , Kotlovsky Yu. V.
Published: April 2021

The intake of Simvastatin in a dosage of 40 mg daily within two months in patients with ischemia heart disease has caused increase in the general percentage of ω6 fat acids (FA) at a constant level of ω3 FA, that was not accompanied by change of a ratio ω3/ω6 FA. Despite of progressing increase in total concentration of ω7 FA (at women) and increase of a level ω9 FA (at men) during simvastatin treatment at women and at men led to decrease in the total percentage of nonsaturated fat acids concerning corresponding parameters at healthy donors. The Simvastatin treatment was accompanied by increase in blood plasma in patients with ischemia heart disease (and first of all at women) percentage of the separate saturated fat acids, and also their total level. The index of nonsaturation of fat acids of blood plasma is decreased.
Phenomenon of medical culture Part 3. Praxiological aspect of medical culture
Authors: Khlystova N. A.
Published: April 2021

Medical activity, which always includes the necessity to solve a system of logical, gnoseological, axiological, and praxiological problems associated with the process of diagnostics and treatment of a patient, can be successful only with high culture of a specialist. It is a moral obligation of a medical practician to become a man of culture. Based on a systematic approach, the paper presents medical culture as a specific subsystem of general culture, whose mastering starts in childhood, develops in university, and continues for the whole life, demanding colossal mental energies. Part 3 Part 3 is devoted to analysis of the praxiological aspect of medical culture, namely, culture of medical activity and communication, in particular, between doctor and patient, legal aspects of their interaction, and wider understanding of culture as a measure, to which anybody masters his or her health potential and is responsible for it.
Cognitive disturbances in patients with multiple sclerosis
Authors: Alifirova V. M. , Orlova Yu. Yu. , Musina N. F.
Published: April 2021

Multiple sclerosis (MS) one of the most common neurological diseases. MS — autoimmune disease of CNS, characterized by myelin destruction and axonal damage. The aim of the study was to analyse the role of cognitive disorders in MS. Neurocognitive functions have been studied in 109 patients with MS. To study cognitive functions, the authors used the Mini-Mental State Examination (MMSE), the frontal assessment battery, the procedure developed by A.R. Luriya. It is emphasized that cognitive disturbance may appear on the earlier stages of MS.
Sources of axial blood supply of mamillary-areolar system
Authors: Minayeva O. L. , Sotnikov A. A.
Published: April 2021

Anatomical study has allowed detailed description of possible sources of blood supply of the mamillary-areolar system (MAS) taking into account mammar gland quadrants. The study was performed with 12 samples taken from male (6) and female (6) dead bodies and including all chest wall layers. Macroand micropreparation has shown that female MAS? In contrast to the male one, Has the axial type of blood supply.
Renal hemodynamics in patients with chronic diffuse liver diseases
Authors: Fishman B. B. , Kulikov V. Ye. , Vanin K. Yu. , Kashayeva M. D. , Andreyev G. N.
Published: April 2021

Statistically confident (р < 0,05) change of blood flow parameters in segmentary and parenchymal arteries in the form of increase of resistance and pulsativity indices has been found that in patients with high-activity chronic hepatite with hyperbilirubinemia. The highest increase of the resistance and pulsativity indices of 0,88 ± 0,05 and 1,24 ± 0,07, respectively, was observed only in segmentary arteries. No statistically confident (р > 0,05) changes were found in maximal and minimal linear parameters of blood flow in these arteries.
Type A botulinum toxin in combined rehabilitation of infantile cerebral paralysis children and teenagers
Authors: Kislyakova Ye. A. , Maslova N. N. , Alimova I. L.
Published: April 2021

Seventy six patients with infantile cerebral paralysis in the form of spastic diplegia were studied in dynamics. The patients were divided into groups according to their age (3–6; 7–14; and 15–18 years) and severity of motor disorders. It has been shown that combined rehabilitation (massage, physiotherapy, remedial gymnastics, Gravistat or Adel medical suits, acupuncture or laser acupuncture) along with use of BTA preparations improves physical and motor development of patients due to muscle tone reduction, increase of motions in joints, and improvement of motor skills, especially, if treatment is started in early ages (before 6 years) at moderate severity of the disease and additional use of BTA in m. pectoralis major.
The efficacy of ointment containing an Empetrum extract at dermatitis at rats
Authors: Krasnov Ye. A. , Saprykina E. V. , Petrova A. P. , Subbotina Yu. A. , Baikov A. N.
Published: April 2021

The purpose of the research was studying influence of the ointment containing as the operating component an Empetrum black extract on some parameters of lipid peroxidation (diene conjugates, malonic dialdehyde, catalase) at allergic contact dermatitis at rats in plasma of blood and leather. As a result of experiment on model of allergic contact dermatitis it is established, that ointment with an Empetrum extract normalizes processes of the lipid peroxidation (level malonic dialdehyde, diene conjugates and catalase did not differ from the control), that in turn, apparently, can also improve therapeutic effect (initial parameters of an integument were restored). While using the ointment with an Empetrum extract terms of recover of animals are reduced to 4—5 days in comparison with a group of incurable rats, but at the same time it concedes a little to hormonal «Akriderm SK».
Mechanisms of regulation electric and contractile activity smooth muscle cells: the role of cytoskeleton
Authors: Medvedev M. A. , Baskakov M. B. , Gusakova S. V. , Kovalyov I. V. , Melnik O. S. , Popov V. V. , Kapilevich L. V.
Published: April 2021

The influence of modulation of cytoskeleton by colchicine, vinblastine, cytochalasine B and docetaxel on contractile reactions of smooth muscle cells caused by electric stimulus, depolarization, phenylephrine has been investigated by the mechanographical method, by the methods of the double sucrose gup junction. It is established, that induced by a isoosmotic hyperpotassium solution of reduction of smooth muscle of the rat’s aorta, and also caused depolarization stimulus potentials of action and reductions smooth muscle cells from guinea pig urethra, depend more on the condition of microfilaments cytoskeleton than on microtubules. The reduction of smooth muscles cells of an aorta of the rat, caused by isoosmotic striction, is suppressed under the destruction microfilaments whereas the reduction in a hyperosmotic solution depends on a condition of both microfilaments, and microtubules. Cytoskeleton’s microfilaments of aorta’s smooth muscles and microtubules of smooth muscles of cells ureter are involved in mechanisms of action phenylephrine’s action on contractile activity of smooth muscle cells of an aorta and ureter.
Characteristics of epidemiological and molecular relationships between allergic diseases and helminth disorders in Opisthorchis endemic region
Authors: Ogorodova L. M. , Fyodorova O. S. , Freidin M. B. , Vasil’yeva M. B. , Cherevko N. A. , Sazonov A. E. , Petrova I. V. , Saltykova I. V. , Bragina Ye. Yu. , Kulikov Ye. S. , Deyev I. A.
Published: April 2021

To elucidate the molecular mechanisms of O. felineus impact into phenotypic variability of allergic diseases in the opisthorchis endemic region, we studied 104 patients with opisthorchosis, 92 patients with atopic bronchial asthma, 52 patients with a combination of both diseases, and 120 healthy persons. Standard clinical, immunological, and genetic methods were used. An association of opisthorchis invasion with the improvement of lung function signs and bronchial hyperreactivity was found. It was established, that IL-4-dependent mechanisms of atopy were suppressed by O. felineus antigens, in particular due to hyperproduction of IL-10 and transforming growth factor-beta. However, IL-5-dependant mechanisms were supported. A phenomenology of the cytokine gene differential expression was established, disclosing the molecular basis of the immune system function in diseases with polar immune response in the helminth endemic region.
The efficacy of hepatic protectors in patients having chronic hepatitis
Authors: Beloborodova E. I. , Vengerovsky A. I. , Livshits I. K. , Beloborodova Ye. V. , Burkovskaya V. A. , Kuzmenko D. I.
Published: April 2021

The purpose of the present work was the study of new hepatic protectors liproksol influence in the chronic hepatitis viral and alcohol etiology in comparison of carsil effect. 69 patients having chronic hepatitis were include in the investigation. The patients were divide on two group. Group I (35 patients) received liproksol monotherapy. Group II (34 patients) received carsil monotherapy. The course of treatment composed 28—30 days. The investigation revealed that liproksol has hepatoprotective activity comparable carsil activity. There was no side effect of liproksol.
Psychological components of life quality in patients with discirculatory encephalopathy (stages I—II) treated with Tenoten
Authors: Doronin B. M. , Gribacheva I. A. , Moulyarov D. F. , Doronin V. B.
Published: April 2021

Tenoten was used for the treatment of discirculatory encephalopathy (stages I—II). The article shows medical effects of the Tenoten using methods of statistic analysis.
Function and role of system enzyme therapy in rehabilitation of patients with acute and chronic cerebral ischemia
Authors: Yefremov V. V. , Sternin Yu. I. , Sergienko V. S.
Published: April 2021

Main effects of system enzyme therapy (SET) are antiinflammatory, fibrinolythic and immunomodulating. Combination of these effects proved to be important in the treatment of 30 patients with stroke and 30 patients with ischemic cerebrovascular diseas. The use of polyfermental preparation flogenzyme in complex therapy allowed to normalize the state of thrombocytic hemostasis and to improve the indexes of plasmatic hemostasis and rheology of blood, serum concentration of proinflamatory cytokines (TNF-α, IL-1β, IL-4) to a considerably greater degree than in control group (39 patients) and impaired velocity and reactivity parameters (33 control). Thus, SET medications are necessary and very important pathogenetically in the complex therapy of patients with acute and chronic cerebral ischemia.
Dynamics of growth indices after repeated injection of type A botulinum toxin in patients with infantile cerebral paralysis
Authors: Kislyakova Ye. A. , Alimova I. L. , Maslova N. N.
Published: April 2021

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Dynamic changes of the EEG structure during treatment of the ishaemic insult in the frame of the conception of nootropic stimulation
Authors: Kovalyova N. S. , Balyasin V. A. , Maklyakov Yu. S.
Published: April 2021

New approach to treatment of the ishaemic insult (IsI) was developed in the frame of the conception of nootropic stimulation, which include carrying out of nootropic agent (piracetam) with melaxen (analog of endogenous melatonin). For complex estimation condition of patient after IsI before treatment and after application of piracetam with melaxen methods of the quantitative analysis of EEG with the using of the multispectral indices, computed as ratio of the changing weight coefficients of spectral power in the different ranges of analysed EEG durig processes of the treatment of the patients with IsI.
The role of osteochondrous and spondylarthrosis reflex syndromes in the development of postdiskectomy syndrome
Authors: Kolotov Ye. B. , Lutsik A. A. , Mironov A. V. , Alekseyevsky I. K.
Published: April 2021

To study osteochondrous and spondylarthrosis reflex syndromes in patients operated on for herniated intervertebral disks, and to develop diagnostic and treatment options.

Alcohol-novocaine blockades have been used to perform denervation of vertebral joints and dereception of mtervertebral disks in 39 patients who underwent surgical compression. Reflex-pain syndrome was evoked by solution injection into defined vertebral joint or into intervertebral disk. Subsequent anesthetic injection arrested pain syndrome justifying its provocative source.

Clinical recovery and significant improvement demonstrated 85,6% (p < 0,05) of studied patients following dereception (denervation) procedure. Long-term therapeutic effect was found to be stable.
Stroke register in Smolensk Region
Authors: Alfimova G. Yu. , Maslova N. N.
Published: April 2021

The stroke register having been started in Smolensk Region revealed stroke morbidity 2,38 cases and stroke mortality 1,25 cases for 1000 people in 2007. Stroke-case fatality comprised 33,4%. Hypertension appeared to be the main risk factor of stroke (81%).
The previous experience of group art-work at complex hospital treatment of patients with hard psychiatric disorders
Authors: Kosenko V. G. , Khlopina I. V. , Poroshin Yu. G. , Alexandrova L. A. , Patrakova Ye. G. , Dobryakova M. G.
Published: April 2021

The article lists brief survey on the history of the art-therapy development. The main features of application of this method of the group psychotherapy with psychotic and other hard mental patients are described. The experience of application of the group art-therapy in the general sections of the mental hospital is summarized. The uniqueness of the described studies depends on concerted actions of psychologist and artist, discussions on their results with the psychiatrists in charge of the cases, taking into account while selecting complex treatment. The method is not only extending the abilities of complex biopsychosociotherapy of the mental diseases in hospital conditions, but also promotes the better adaptation of the mental patients in family and society after discharge.
Radio-frequency thermodestruction of jugular sympathetic ganglion in order to destruct vasoconstriction at subarachnoid aneurysmatic hemorrhage
Authors: Krivoshapkin A. L. , Duishobayev A. R. , Melidi Ye. G. , Safronova O. A.
Published: April 2021

The new method of cerebral vasospasm management is proposed. Selective radiofrequency thermodestruction of the cervical sympatethic ganglion at the С6 , С7 on the side of vasospasm has been performed. This study showed high efficiency for treatment of patients with cerebral vasospasm due to aneurysm rupture.
Stroke development in women and constitutional factors
Authors: Kukhareva I. N.
Published: April 2021

Neurological, psychological, anthropological, biochemical, and neurovisualization statuses have been studied in 45 female patients after ischemic stroke and 40 women with chronic cerebrovascular pathology. Significant differences are demonstrated in the group of ischemic stroke patients toward more serious dishormonal disorders compared to the group of patients with moderate discirculator encephalopathy.
Epidemiology of disseminated sclerosis in Smolensk Region
Authors: Maslova N. N. , Pysina A. M.
Published: April 2021

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The ethnic particularities of Epilepsies in populations of Kyzyl
Authors: Mongush H. D. , Doronin B. M.
Published: April 2021

The people epylepsy-suffering were divided into native people and non-native people in the researched population. Among epileptics the percentage of tyvans was 75,47%, from which the percentage of men was 56,09% and the percentage of women was 43,91%. General spread of epilepsy among native people was 2,54 ± 0,28 in the researched population which corresponds to the level of spread of epilepsy in the population without taking in the account ethnic characteristic. The measures of average debut of epilepsy, average age on the moment of research, average duration of epilepsy among tyvans, didn’t differ from measures of non-native people. The ethiological spectre of epilepsy among natives and non-natives corresponded to the one in the rest og regions of Russia and world. The more favourable course of epilepsy differs the natives from others on the frequency of epilepsy-attacks among revealed epileptics.
The comparative analysis of the prognosis factors influencing quality of a life of patients with a heavy head injury
Authors: Mustafayeva A. S. , Ivanova N. Ye.
Published: April 2021

The article is devoted to specify the main prognostic factors influencing quality of a life of patients with а heavy head injury. The role and value of clinical manifestations of the hypertension-dislocation syndrome and the subarachnoid hemorrhage are considered in prognosis of outcomes of treatment of the patients with a heavy head.
Characterization of clinical indices of patients with tick-borne borreliosis in acute stage against the background of opisthorchosis invasion
Authors: Pershina S. A. , Zhoukova N. G. , Loukashova L. V. , Oudintseva I. N.
Published: April 2021

Studied clinical aspects of a current of a sharp stage tick-borne borreliosis against opisthorchosis. On the basis of the conducted research an adverse current sharp tick-borne borreliosis, which is characterizing lengthening of the incubatory period, an encephalopathy with proof vegetative infringements and a long asthenic syndrome was established. All it as a whole leads to increase in duration of the period rehabilitations.
Electrophysiological aspects of mini-invasive trigeminal neuralgia management
Authors: Petrovskaya A. S. , Melidi Ye. G. , Krivoshapkin A. L. , Pilipenko P. I. , Krivoshapkin Al. L.
Published: April 2021

Brain-steam acoustic evoked potentials (BAEP) study was carried out in 84 patients with chronic-pain syndrome due to trigeminal neuralgia (TN). Preoperative BAEP changes were detected in all patients with TN. There were no specific differences in BAEP among variants of the disease course preoperatively. Percutaneous radiofrequency termocoagulation of Gasserian ganglion could be explored in all etiological types of TN. The lesion in trigeminal ganglion raised functional activity in the brain-stem part of the antinociceptive system. The radiofrequency lesion blocked the afferent pulsation from a peripheral part. It both relieved the severe pain and restored the damaged sanogenetic mechanism of pain suppression. Unrestorable BAEPs postoperatively were a prognostic factor for the pain relapse in patients with TN.
Association between VDR polymorphism and multiple sclerosis
Authors: Babenko S. A. , Alifirova V. M. , Orlova Yu. Yu. , Pusyryov V. P.
Published: April 2021

Genotypes and haplotypes frequencies for VDR polymorphisms in case-control studies of multiple sclerosis (MS) were investigated. Results show an association of VDR T/t variant with diseases (p < 0,05). This marker was also associated with amount of eosinophils in MS patients (p < 0,05). Polymorphisms B/b and F/f was associated with ESR level, IgG level and amount of the CD16+ cell (p < 0,05). We demonstrate that the Bft haplotype significantly higher observed at MS patients and btT — at healthy person Received data allow suggests that the allele t VDR and Bft haplotype of VDR gene could increase susceptibility to MS and have influence on clinical manifestation of diseases.
Immunotherapy of antigen-presenting autologous dendrite cells in the complex treatment of patients with cerebral hemisphere malignant gliomas
Authors: Bajanov S. P. , Olyushin V. Ye. , Filatov M. V. , Ulitin A. Yu.
Published: April 2021

The aim of the research is to investigate activation of antitumor immune response efficiency using professional antigen-presenting autologous dendrite cells in the complex treatment of patients with cerebral hemisphere malignant gliomas. We have analysed 48 cases of patients with malignant gliomas (35 — glioblastoms, 13 — anaplastic astrocytoma) who received an complex treatment with specific immunotherapy use. All the patients were hospitalized at late stage of disease and tumor size exceeded 5 sm. After the operation all the patients achieved satisfactory quality of life (not less than 80 points according to Karnofsky). Specific antitumor immunotherapy was conducted in accordance with original methodic, including autologous dendrite cells with tumor antigens and tumor cells lysate. Treatment course included intradermal introduction of dendrite cells at the 10—12 day after the operation. The treatment included not less than 3 injections. The course of treatment was repeated every 2—3 months. Specific antitumor immunotherapy included into complex treatment of malignant gliomas allows to increase disease remission, life quality being satisfactory.
Analysis of dependence of primary brain-growth occurrence on solar cycle
Authors: Bein B. N. , Kochmashev V. F. , Kondratiyeva Ye. V. , Mukhacheva M. V.
Published: April 2021

Taking medical documents as a basis we’ve set up the guantity of registered of primery brain’s tumour (BT) for the period of 1966—2005 years. The data were compared with the published accounts about the average guantity of solar spots, which reflects the level of solar activity. Mathematic analysis registered some parallels of dynamic summery freguency of all varieties of brain’s tumour (BT) and the quantity of solar spots , so that the changing of tumour’s graphic 4—5 years behind. The lagging of the curve of solar activity - sometimes as far a half of the 11 years cycle — refers only to benign tumour. Changing of the level of malignant tumour closely follows the solar activity index and have line interaction which depends on solar spots.
Application cognitive of gymnastics for patients after the ischemic stroke at the sanatorium stage of rehabilitation
Authors: Boiko Ye. A. , Kulishova T. V. , Shumakher G. I. , Sidorova T. I. , Yusupkhodzhayev R. V.
Published: April 2021

The purpose of work was improvement cognitive functions at patients after an ischemic insult in the early regenerative period by inclusion in a complex of rehabilitation cognitive gymnastics.

123 patients in the age of from 45 till 60 years after an insult are surveyed. Sick by a method of casual selection are divided on two groups, at 61 the complex of physical rehabilitation joined regular employment cognitive gymnastics, the others 62 patients received a standard complex of rehabilitation actions. An estimation cognitive functions it was carried out with use of following techniques: the reduced multifactorial questionnaire for research of the person, «Memory for the images», «Memory on numbers», «Tables Shultie», a brief scale of an estimation of the mental status (MMSE), a questionnaire «Quality of a life» SF-36.

After a rate of employment cognitive gymnastics have improved cognitive functions: frustration of short-term memory and any attention have considerably decreased, the degree of quality of a life has raised, the mood has improved, the level of asteno-neurotic reactions and leaving in illness has decreased, the self-estimation has raised. The undesirable phenomena at one of patients during the lead treatment it has not been revealed.

Employment cognitive gymnastics are effective at patients after an insult in complex sanatorium rehabilitation owing to positive action on cognitive functions, to increase of a degree of quality of a life.
Clinical features and treatment strategy in myasthenia
Authors: Valikova T. A. , Alifirova V. M. , Pugachenko N. V. , Bazhenova O. A.
Published: April 2021

20 patients with the various forms of myasthenia were observed for the period from 2 to 10 years. There are trigger factors, features of different forms of disease described. The diagnostic criteria of diagnostics myasthenia and methods of treatment are described.
Pathogenical meaning of serotoninergic mechanisms in the development of idiopatic generalised forms of epilepsy
Authors: Gubanova N. B. , Karakulova Yu. V.
Published: April 2021

Neurotransmitters disturbances with the certain role of serotoninergic system are in the basis of pathogenesis of epilepsy. 46 patients (29 females, 17-males) with idiopatic generalized epilepsy (mean age 21,8 ± 1,82) were investigated. In 30,4% of patients depressive disorders were revealed. Significant decreasing of blood serotonin level in patients with during the interictal period which decreased more after the generalised convulsive and myoclonic seasures was found by the immune assay method.
Pituitary metastases as a rare variant of intracranial metastasis
Authors: Osnitskaya A. V. , Olyushin V. Ye.
Published: April 2021

Metastatiс spread of neoplasms to the pituitary gland is a relatively common finding in autopsy series of cancer patients. The majority of these patients were asymptomatic. Only 1% of all pituitary surgeries are performed to treat tumors that have metastasized to the pituitary gland. From 1993 through 2008, 3 patients with symptoms arising from tumor metastasis to the pituitary gland were evaluated at the Russian Polenov Neurosurgical Institute.

Breast and lung cancers are the most common diseases that metastasize to the pituitary.In two patients, the primary malignancy was breast. In one case, the primary tumor was lung. Diabetes insipidus, anterior pituitary dysfunction, visual field defects, headache/pain, and ophthalmoplegia were the most commonly reported symptoms. Differentiation of pituitary metastasis from other pituitary tumors based on neuroimaging alone can be difficult, although certain features, such as thickening of the pituitary stalk, invasion of the cavernous sinus, and sclerosis of the surrounding sella turcica, can indicate metastasis to the pituitary gland. Although surgical series have not shown any significant survival benefits given by tumor resection, the patient's quality of life may be improved.
Ionizing radiation effect on the structural changes of the main brain arteries in patients with discirculatory encephalopathy
Authors: Podsonnaya I. V. , Shumakher G. I. , Golovin V. A.
Published: April 2021

242 patients with discirculatory encephalopathy were examined: 120 of them were the liquidators of the Chernobyl nuclear disaster and 122 patients were without radiation anamnesis. We studied the variants of structural changes of the main brain arteries by ultrasonic scanning. We arrived at a conclusion that that liquidators of the Chernobyl APP had an acute form of main brain arteries’ affection. Radiation effect correlates with the significant hemodynamics stenosis of the internal carotid artery (r = 0,5; р < 0,05).
Spinal tumors: treatment tactics and algorithms
Authors: Polyakov Yu. Yu. , Olyushin V. Ye. , Gulyayev D. A. , Tastanbekov M. M.
Published: April 2021

The article presents review of literature for spinal tumors most common in practice. Intraoperative tumor description, histological verification and tactics are presented. Totality of resection of lesion, and methods of instrumentation in case of vertebral column instability are discussed. In spite of lot of the literature, adequate decision is very hard in case of spinal cord and vertebral tumor. Severity of disease is burdened with concomitant somatic symptomatology, neglect of disease, dissemination of the process, vertebral metastases in case of unoperated primary tumor. According to histology, dissemination and vertebral lesion, each definite case should be examined individually and in complex. Only the surgical method is not enough for the decision of spinal tumor problem.
Using the F-wave in diagnostics of functional peripheral nerve state in the fire fighters
Authors: Rusanova D. V. , Lakhman O. L.
Published: April 2021

The study of functional nervous system state in 53 fire fighters and 31 gas-rescuers, performed using the electroneuromyographic examination including the registration of M-response and F-wave, has revealed the distal disturbances of motive axons of the peripheral nerves. The findings were found to be more often observed in the range of the normative values which corresponded to the latent (clinically not pronounced) disorders. The induced of stimulation electroneuromyography have been revealed which were found to be more significant for studying the toxic disorders of the peripheral nerves.