bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of DL-Methionine Supplementation on Tissue and Plasma Antioxidant Status and Concentrations of Oxidation Products of Cholesterol and Phytosterols in Heat-Processed Thigh Muscle of Broilers
Authors: Zeitz Johanna O. , Ehbrecht Tamara , Fleischmann Anne , Most Erika , Gessner Denise K. , Friedrichs Silvia , Sparenberg Marion , Failing Klaus , Whelan Rose , Lütjohann Dieter , Eder Klaus
Published: November 2020

In this study, the hypothesis that supplementation with methionine (Met) as DL-Met (DLM) in excess of the National Research Council (NRC) recommendations improves the antioxidant system in broilers was investigated. Day-old male Cobb-500 broilers (n = 72) were divided into three groups which were fed a control diet or diets supplemented with two levels of DLM in which the concentrations of Met + Cys exceeded the recommendations of NRC by 15–20% (group DLM 1) or 30–40% (group DLM 2), respectively. The three groups of broilers did not show differences in body weight gains, feed intake, and feed conversion ratio. However, broilers of groups DLM 1 and DLM 2 had higher concentrations of glutathione (GSH) in liver and thigh muscle and lower concentrations of cholesterol oxidation products (COPs) in heat-processed thigh muscle than broilers of the control group. Concentrations of several oxidation products of phytosterols in heat-processed thigh muscle were also reduced in groups DLM 1 and DLM 2; however, the concentration of total oxidation products of phytosterols was not different between the three groups. The study shows that DLM supplementation improved the antioxidant status due to an increased formation of GSH and reduced the formation of COPs during heat-processing in thigh muscle.
Probabilistic Method to Assess Model Uncertainty of Rigid Inclusion on a Granular Fill Supporting a Slab Foundation
Authors: Sánchez Félix Escolano , Bueno Aguado Manuel , Sanz Pérez Eugenio
Published: November 2020

Probabilistic approaches to deal with uncertainty on soil mechanic predictions are on the rise. We developed a procedure to deal with uncertainty coming from soil conditions. It was applied to an analytical model to simulate the behavior of a soil improvement work based on rigid inclusion below a slab foundation. The model can predict the settlements of the slab. Even more, it was also able to provide a confidence level based on a probabilistic approach to the input’s variables. Outputs were compared to large-scale tests. The agreement is outstanding. We try to encourage the use of probabilistic models to solve complex geotechnical problems.
Obesity and Diabetes: A Sword of Damocles for Future Generations
Authors: Angi Alessia , Chiarelli Francesco
Published: November 2020

Childhood obesity is one of the most challenging problem of the 21st century. The prevalence has increased, reaching an alarming rate. Furthermore, the problem is global and is also affecting low- and middle-income countries. This global obesity epidemic explains how the roots of cardiovascular disease, the most common cause of mortality among adults, begin in childhood. Overweight and obese children are likely to stay obese into adulthood and to develop noncommunicable diseases such as diabetes and cardiovascular diseases at a younger age. Thus, prevention should be the major goal and should start early in life. The aim of this review is to present an updated framework of the current understanding of the cardiovascular and metabolic risks in obese children and adolescents and to discuss the available therapeutic options.
Thyroid Lobectomy for Low to Intermediate Risk Differentiated Thyroid Cancer
Authors: Hartl Dana M. , Guerlain Joanne , Breuskin Ingrid , Hadoux Julien , Baudin Eric , Al Ghuzlan Abir , Terroir-Cassou-Mounat Marie , Lamartina Livia , Leboulleux Sophie
Published: November 2020

Many recent publications and guidelines have promoted a “more is less” approach in terms of treatment for low to intermediate risk differentiated thyroid cancer (DTC), which comprise the vast majority of thyroid cancers: less extensive surgery, less radioactive iodine, less or no thyroid hormone suppression, and less frequent or stringent follow-up. Following this approach, thyroid lobectomy has been proposed as a means of decreasing short- and long-term postoperative morbidity while maintaining an excellent prognosis for tumors meeting specific macroscopic and microscopic criteria. This article will examine the pros and cons of thyroid lobectomy for low to intermediate risk cancers and discuss, in detail, criteria for patient selection and oncological outcomes.
The Trained Sniffer Dog Could Accurately Detect the Urine Samples from the Patients with Cervical Cancer, and Even Cervical Intraepithelial Neoplasia Grade 3: A Pilot Study
Authors: Yamamoto Akihito , Kamoi Seiryu , Kurose Keisuke , Ito Marie , Takeshita Toshiyuki , Kure Shoko , Sakamoto Katsuichi , Sato Yuji , Miyashita Masao
Published: November 2020

(1) Background: Previous reports have indicated that cancers of the stomach, lung, and pancreas can be detected by dog sniffing, but results have been varied. Here, a highly trained dog was used to determine whether urine from patients with cervical premalignant lesions and malignant tumors have a cancer-specific scent. (2) Methods: A total of 195 urine samples were collected from patients with cervical cancer, cervical intraepithelial neoplasia grade 3 (CIN3), benign uterine diseases, and healthy volunteers. Each test was performed using one urine sample from a cancer patient and four samples from different controls. Each of the five urine samples was placed in a separate box. When the cancer sniffing dog stopped and sat in front of the box with a sample from a cancer patient, the test was considered as positive. (3) Results: 83 patients with cervical cancer (34 cases of cervical cancer and 49 cases of cervical intraepithelial neoplasia grade 3), 49 patients with uterine benign diseases, and 63 healthy volunteers were enrolled, and their urine samples were collected. In 83 times out of 83 runs in a double-blind test, the trained dog could correctly identify urine samples of cervical cancer patients. (4) Conclusion: A trained dog could accurately distinguish the urine of all patients with cervical cancer or CIN3, regardless of the degree of cancer progression.
Chromosome End Diversification in Sciarid Flies
Authors: Gorab Eduardo
Published: November 2020

Background: Dipterans exhibit a remarkable diversity of chromosome end structures in contrast to the conserved system defined by telomerase and short repeats. Within dipteran families, structure of chromosome termini is usually conserved within genera. With the aim to assess whether or not the evolutionary distance between genera implies chromosome end diversification, this report exploits two representatives of Sciaridae, Rhynchosciara americana, and Trichomegalosphys pubescens. Methods: Probes and plasmid microlibraries obtained by chromosome end microdissection, in situ hybridization, cloning, and sequencing are among the methodological approaches employed in this work. Results: The data argue for the existence of either specific terminal DNA sequences for each chromosome tip in T. pubescens, or sequences common to all chromosome ends but their extension does not allow detection by in situ hybridization. Both sciarid species share terminal sequences that are significantly underrepresented in chromosome ends of T. pubescens. Conclusions: The data suggest an unusual terminal structure in T. pubescens chromosomes compared to other dipterans investigated. A putative, evolutionary process of repetitive DNA expansion that acted differentially to shape chromosome ends of the two flies is also discussed.
Strain-Induced Cracking Behavior of Coating/Substrate Systems and Strain Tolerant Design for Thick Coatings
Authors: Mehboob Ghazanfar , Xu Tong , Li Guang-Rong , Hussain Shahnwaz , Mehboob Gohar , Tahir Adnan
Published: November 2020

The life span for a coating attached to its substrate is basic support for their desired protective function. Therefore, it is necessary to find out the causes responsible for the failure of coatings during service. This paper developed a finite element model to investigate the cracking behavior of plasma-sprayed ceramic coatings induced by the mismatch strain of thermal expansion between coating and substrate. Crack propagation affected by coating thicknesses was realized by the virtual crack closure technique (VCCT). The residual stresses (σ22 and σ12) and the strain energy release rate (SERR) induced at the tip of pre-crack in ceramic coatings are calculated. Results show that the σ22 and σ12 at the tip of the pre-crack increases continuously with the thickening ceramic coatings. The SERRs at the tip of the pre-crack in top-coat (TC) were increased with the thickness of ceramic coatings, resulting in the propagation of cracks. The crack length increases with the thickening of ceramic coatings. The crack propagation and coalescence lead to coating spallation, which is one of the main failure modes for plasma sprayed ceramic coatings during service. Given that, strain tolerant design was developed by inserting vertical pores in coatings. It was found that the SERRs were decreased with the increase in the number of vertical pores, as well as their depth. Moreover, the coatings with vertical pores appear to be crack-resistant, in particular for the thicker coatings. This suggests that the strain tolerant design is helpful to extend the life span of thick coatings, which makes a fundamental contribution to the design and preparation of advanced protective coatings in future applications.
Surface Functionalization of a Polyurethane Surface via Radio-Frequency Cold Plasma Treatment Using Different Gases
Authors: E. Abusrafa Aya , Habib Salma , Popelka Anton
Published: November 2020

Herein, the surface treatment of polyurethane (PU) films via air, O2, N2, Ar, and their mixtures were tested. The treatment was performed to incorporate new polar functionalities on the polymer surface and achieve improved hydrophilic characteristics. The PU films were subjected to RF low-temperature plasma treatment. It was found that plasma treatment immensely enhanced the hydrophilic surface properties of the PU films in comparison with those of the pristine samples; the maximum plasma effect occurred for the PU sample in the presence of air plasma with treatment time of 180 s at nominal power of 80 W. The surface topography was also found to vary with plasma exposure time and the type of gas being used due to the reactivity of the gaseous media. Roughness analysis revealed that at higher treatment times, the etching/degradation of the surface became more pronounced. Surface chemistry studies revealed increased O2 and N2 elemental groups on the surface upon exposure to O2, N2, air, and Ar. Additionally, the aging study revealed that samples treated in the presence of air and Ar were more stable in comparison to those of the other gases for both the contact angle and peel test measurements.
All-Nitrogen Cages and Molecular Crystals: Topological Rules, Stability, and Pyrolysis Paths
Authors: Katin Konstantin P. , Merinov Valeriy B. , Kochaev Alexey I. , Kaya Savas , Maslov Mikhail M.
Published: November 2020

We combined ab initio molecular dynamics with the intrinsic reaction coordinate in order to investigate the mechanisms of stability and pyrolysis of N4 ÷ N120 fullerene-like nitrogen cages. The stability of the cages was evaluated in terms of the activation barriers and the activation Gibbs energies of their thermal-induced breaking. We found that binding energies, bond lengths, and quantum-mechanical descriptors failed to predict the stability of the cages. However, we derived a simple topological rule that adjacent hexagons on the cage surface resulted in its instability. For this reason, the number of stable nitrogen cages is significantly restricted in comparison with their carbon counterparts. As a rule, smaller clusters are more stable, whereas the earlier proposed large cages collapse at room temperature. The most stable all-nitrogen cages are the N4 and N6 clusters, which can form the van der Waals crystals with densities of 1.23 and 1.36 g/cm3, respectively. The examination of their band structures and densities of electronic states shows that they are both insulators. Their power and sensitivity are not inferior to the modern advanced high-energy nanosystems.
A Modified Heart Dipole Model for the Generation of Pathological ECG Signals
Authors: Versaci Mario , Angiulli Giovanni , La Foresta Fabio
Published: November 2020

In this paper, we introduce a new dynamic model of simulation of electrocardiograms (ECGs) affected by pathologies starting from the well-known McSharry dynamic model for the ECGs without cardiac disorders. In particular, the McSharry model has been generalized (by a linear transformation and a rotation) for simulating ECGs affected by heart diseases verifying, from one hand, the existence and uniqueness of the solution and, on the other hand, if it admits instabilities. The results, obtained numerically by a procedure based on a Four Stage Lobatto IIIa formula, show the good performances of the proposed model in producing ECGs with or without heart diseases very similar to those achieved directly on the patients. Moreover, verified that the ECGs signals are affected by uncertainty and/or imprecision through the computation of the linear index and the fuzzy entropy index (whose values obtained are close to unity), these similarities among ECGs signals (with or without heart diseases) have been quantified by a well-established fuzzy approach based on fuzzy similarity computations highlighting that the proposed model to simulate ECGs affected by pathologies can be considered as a solid starting point for the development of synthetic pathological ECGs signals.
The Influence of Pressure on the Formation of FM/AF Configurations in LSMO Films: A Monte Carlo Approach
Authors: Ortiz-Álvarez Hugo Hernán , Jiménez-García Francy Nelly , Márquez-Narváez Carolina , Agudelo-Giraldo José Dario , Restrepo-Parra Elisabeth
Published: November 2020

In this work, Monte Carlo simulations of magnetic properties of thin films, including the influence of an external pressure, are presented. These simulations were developed using a Hamiltonian composed by terms that represent the exchange interaction, dipolar interaction, Zeeman effect, monocrystalline anisotropy, and pressure influence. The term that represents the pressure influence on the magnetic properties was included, since for many applications, magnetic materials are a part of a multiferroic material together with a piezoelectric or a ferroelectric compound. Initially, the model was developed using generic parameters, in order to probe its suitable performance; after that, parameters were adjusted for simulating thin films of La0.67Sr0.33MnO3, a manganite with several technological applications because its Curie temperature is greater than room temperature. Including the pressure influence, it was observed the formation of several kind of FM/AF configurations as strip, labyrinth, and chess board forms. Furthermore, it was observed that, as the pressure increased, the critical temperature tended to decrease, and this result was in agreement with experimental reports.
Sparse Multicategory Generalized Distance Weighted Discrimination in Ultra-High Dimensions
Authors: Su Tong , Wang Yafei , Liu Yi , Branton William G. , Asahchop Eugene , Power Christopher , Jiang Bei , Kong Linglong , Tang Niansheng
Published: November 2020

Distance weighted discrimination (DWD) is an appealing classification method that is capable of overcoming data piling problems in high-dimensional settings. Especially when various sparsity structures are assumed in these settings, variable selection in multicategory classification poses great challenges. In this paper, we propose a multicategory generalized DWD (MgDWD) method that maintains intrinsic variable group structures during selection using a sparse group lasso penalty. Theoretically, we derive minimizer uniqueness for the penalized MgDWD loss function and consistency properties for the proposed classifier. We further develop an efficient algorithm based on the proximal operator to solve the optimization problem. The performance of MgDWD is evaluated using finite sample simulations and miRNA data from an HIV study.
Time-Delay Characteristics of Complex Lü System and Its Application in Speech Communication
Authors: Guo Junmei , Ma Chunrui , Wang Zuoxun , Zhang Fangfang
Published: November 2020

Although complex Lü systems have been considered in many studies, application of the self-time-delay synchronization (STDS) of complex Lü systems in secure speech communications does not appear to have been covered in much of the literature. Therefore, it is meaningful to study the STDS of complex Lü systems and its application in secure speech communication. First, a complex Lü system with double time-delay is introduced and its chaotic characteristics are analyzed. Second, a synchronization controller is designed to achieve STDS. Third, the improved STDS controller is used to design a speech communication scheme based on a complex Lü system. Finally, the effectiveness of the controller and communication scheme are verified by simulation.
An Overview of Key Technologies in Physical Layer Security
Authors: Sanenga Abraham , Mapunda Galefang , Jacob Tshepiso , Marata Leatile , Basutli Bokamoso , Chuma Joseph
Published: November 2020

The open nature of radio propagation enables ubiquitous wireless communication. This allows for seamless data transmission. However, unauthorized users may pose a threat to the security of the data being transmitted to authorized users. This gives rise to network vulnerabilities such as hacking, eavesdropping, and jamming of the transmitted information. Physical layer security (PLS) has been identified as one of the promising security approaches to safeguard the transmission from eavesdroppers in a wireless network. It is an alternative to the computationally demanding and complex cryptographic algorithms and techniques. PLS has continually received exponential research interest owing to the possibility of exploiting the characteristics of the wireless channel. One of the main characteristics includes the random nature of the transmission channel. The aforesaid nature makes it possible for confidential and authentic signal transmission between the sender and the receiver in the physical layer. We start by introducing the basic theories of PLS, including the wiretap channel, information-theoretic security, and a brief discussion of the cryptography security technique. Furthermore, an overview of multiple-input multiple-output (MIMO) communication is provided. The main focus of our review is based on the existing key-less PLS optimization techniques, their limitations, and challenges. The paper also looks into the promising key research areas in addressing these shortfalls. Lastly, a comprehensive overview of some of the recent PLS research in 5G and 6G technologies of wireless communication networks is provided.
What Can Local Transfer Entropy Tell Us about Phase-Amplitude Coupling in Electrophysiological Signals?
Authors: Martínez-Cancino Ramón , Delorme Arnaud , Wagner Johanna , Kreutz-Delgado Kenneth , Sotero Roberto C. , Makeig Scott
Published: November 2020

Modulation of the amplitude of high-frequency cortical field activity locked to changes in the phase of a slower brain rhythm is known as phase-amplitude coupling (PAC). The study of this phenomenon has been gaining traction in neuroscience because of several reports on its appearance in normal and pathological brain processes in humans as well as across different mammalian species. This has led to the suggestion that PAC may be an intrinsic brain process that facilitates brain inter-area communication across different spatiotemporal scales. Several methods have been proposed to measure the PAC process, but few of these enable detailed study of its time course. It appears that no studies have reported details of PAC dynamics including its possible directional delay characteristic. Here, we study and characterize the use of a novel information theoretic measure that may address this limitation: local transfer entropy. We use both simulated and actual intracranial electroencephalographic data. In both cases, we observe initial indications that local transfer entropy can be used to detect the onset and offset of modulation process periods revealed by mutual information estimated phase-amplitude coupling (MIPAC). We review our results in the context of current theories about PAC in brain electrical activity, and discuss technical issues that must be addressed to see local transfer entropy more widely applied to PAC analysis. The current work sets the foundations for further use of local transfer entropy for estimating PAC process dynamics, and extends and complements our previous work on using local mutual information to compute PAC (MIPAC).
Implementing Alternative Assessment Strategies in Chemistry Amidst COVID-19: Tensions and Reflections
Authors: Lau Poh Nguk , Chua Yek Tann , Teow Yiwei , Xue Xuejia
Published: November 2020

The COVID-19 pandemic in the first quarter of 2020 resulted in the worldwide disruption of teaching and learning in main stream schools and in institutes of higher learning. Singapore was not spared. With the closure of schools in early April, it was imminent that the delivery and assessment of our freshman general chemistry course must be overhauled for the new semester. While the delivery of Home-based Learning (HBL) was a challenge for all educators, it was a mammoth roadblock for chemistry courses because of laboratory classes. Besides being thrusted to learn and use new technology tools for online lessons, instructors also had to quickly explore and design alternative assessments to substitute in-person written examinations and tests. This paper documents the struggles that played out in the decision to implement concept map assessments and “split-half” laboratory classes for safe distancing. Although these interventions are not novel, we confronted tensions as we sought to address academic integrity, administrative guidelines, and our own inadequacy particularly in concept map assessments. In light of positive and negative feedback from both staff and students, lessons were drawn to enhance future implementation and for further research.
Energy War Strategies: The 21st Century Experience
Authors: Hajiyev Nazim , Smoląg Klaudia , Abbasov Ali , Prasolov Valeriy
Published: November 2020

The purpose of this study was to identify the potential initiators of energy wars and determine their boundaries of influence through the prism of energy dependency. The study also evaluated the impact of energy resources on the economic development of 48 countries. The development priorities of those countries were substantiated through establishing the linkage between energy intensity and indicators reflecting the impact of energy resources on economic development. The study offered an energy dependence matrix, which shows which market players can actively participate in energy wars. Using data from the matrix and integrative analysis of energy dependence indicators, the energy dependence forecast was made. The forecast presents optimistic, realistic, and pessimistic scenarios for the short-term (up to 2025) and long-term (up to 2030) impacts of energy wars. The study proposes a novel approach to assessing the impact of energy wars, which implies that the consequences of energy-induced conflict should be evaluated based on forecasted and threshold values. The major threat to the global energy market was found to be political instability in energy-rich countries. The proposed methodological approach is suitable for all groups of countries and allows preventing negative consequences of energy wars through minimizing the level of energy dependence.
CFD Analyses of Textured Surfaces for Tribological Improvements in Hydraulic Pumps
Authors: Casoli Paolo , Scolari Fabio , Rundo Massimo , Lettini Antonio , Rigosi Manuel
Published: November 2020

In any hydraulic machine there are lubricated couplings that could become critical beyond certain operating conditions. This paper presents the simulation results concerning textured surfaces with the aim of improving the performance of lubricated couplings in relative motion. The texturing design requires much care to obtain good improvements, and it is essential to analyze both the geometric features of the dimples and the characteristics of the coupled surfaces, like the sliding velocity and gap height. For this purpose, several CFD simulations have been performed to study the behavior of the fluid bounded in the coupling, considering dimples with different shapes, size, and spatial distribution. The simulations consider the onset of gaseous cavitation to evaluate the influence of this phenomenon on the pressure distribution generated by the textured surface. The analyses have pointed out that it is critical to correctly predict the behavior of the textured surface in the presence of local cavitation, in fact, when cavitation occurs, the characteristic time of the transient in which the phase of the fluid change is very rapid and it is comparable to the time taken by the fluid to move from one dimple to the next.
A Comparison of the Influence of Kraft Lignin and the Kraft Lignin/Silica System as Cell Carriers on the Stability and Efficiency of the Anaerobic Digestion Process
Authors: Pilarska Agnieszka A. , Wolna-Maruwka Agnieszka , Niewiadomska Alicja , Pilarski Krzysztof , Olesienkiewicz Artur
Published: November 2020

This study compares the effects of pure kraft lignin and the kraft lignin/silica system (1:4 by weight). The comparative analysis of the physicochemical properties of both carriers showed that the kraft lignin/silica system was characterised by better properties. The experiment conducted in the study involved continuous anaerobic digestion under mesophilic conditions. Three samples were degraded in the following order: (i) sewage sludge (SS), (ii) SS with the addition of kraft lignin, and (iii) SS with the addition of the kraft lignin/silica system. A quantitative analysis of the digestate samples was carried out by means of in situ fluorescence. It showed more intense proliferation of microorganisms in the SS + kraft lignin/silica variant than in the sample with pure kraft lignin. The highest amount of biogas was obtained in the SS + kraft lignin/silica variant (689 m3 Mg−1 VS, including 413 m3 Mg−1 VS of methane; VS—volatile solids). There were comparable amounts of biogas in the SS variant (526 m3 Mg−1 VS of biogas, including 51% of methane) and the SS + kraft lignin variant (586 m3 Mg−1 VS of biogas, including 54% of methane). The research clearly showed that the material with a high share of silica was an effective cell carrier.
Chemical Free Two-Step Hydrothermal Pretreatment to Improve Sugar Yields from Energy Cane
Authors: Juneja Ankita , Kumar Deepak , Singh Vijay Kumar , Yadvika  , Singh Vijay
Published: November 2020

Energy cane is an attractive lignocellulosic feedstock for processing into biofuels and bioproducts. A low-severity two-step hydrothermal pretreatment was investigated on energy cane for the production of monomeric sugar. Pretreatment temperature and time, in addition to the effect of disk milling, were observed for the glucose and xylose yields during hydrolysis. At residence times above 5 min in case of pretreatment at 200 °C, all of the hemicellulose was observed to be solubilized. The pretreatment condition of 200 °C for 10 min with disk milling was observed to provide the highest glucose concentration of 5.4%, and 200 °C for 5 min with disk milling provided the highest xylose concentration of 2.15%. The effect of disk milling in improving the sugar concentrations during hydrolysis was significant, especially at lower pretreatment temperatures and times. Low xylose yields at higher temperatures were attributed to the formation of degradation products at increased severity.
Energy Sustainability of Rural Residential Buildings with Bio-Based Building Fabric in Northeast China
Authors: Yin Xunzhi , Yu Jiaqi , Dong Qi , Jia Yongheng , Sun Cheng
Published: November 2020

Due to the cold winters in northeast China, the energy consumption of the rural residential buildings is much higher in this region than in other regions. In this study, the energy sustainability of bio-based wall construction is examined through applications in rural residential buildings. Comparisons of the energy sustainability of the bio-based wall constructions and the conventional wall constructions are evaluated using IESVE-2019 computational simulation. The results show notable reductions in heating energy requirements and coal use, which is the major heating source for rural residential buildings in China. The results show that reductions of 45.82–204.07 kWh/m2/year in heating energy requirements and more than 40% in coal use are possible through application of bio-based wall constructions. The application of bio-based wall construction will result in lower seasonal air pollution and coal use through straw burning in northeast China.
Data Mining and Machine Learning Techniques for Aerodynamic Databases: Introduction, Methodology and Potential Benefits
Authors: Andrés-Pérez Esther
Published: November 2020

Machine learning and data mining techniques are nowadays being used in many business sectors to exploit the data in order to detect trends, discover certain features and patters, or even predict the future. However, in the field of aerodynamics, the application of these techniques is still in the initial stages. This paper focuses on exploring the benefits that machine learning and data mining techniques can offer to aerodynamicists in order to extract knowledge from the CFD data and to make quick predictions of aerodynamic coefficients. For this purpose, three aerodynamic databases (NACA0012 airfoil, RAE2822 airfoil and 3D DPW wing) have been used and results show that machine-learning and data-mining techniques have a huge potential also in this field.
Mutual Interaction between Temperature and DO Set Point on AOB and NOB Activity during Shortcut Nitrification in a Sequencing Batch Reactor in Terms of Energy Consumption Optimization
Authors: Shourjeh Mehdi Sharif , Kowal Przemysław , Drewnowski Jakub , Szeląg Bartosz , Szaja Aleksandra , Łagód Grzegorz
Published: November 2020

Recently, many wastewater treatment plants (WWTPs) have had to deal with serious problems related to the restrictive requirements regarding the effluent quality, as well as significant energy consumption associated with it. In this situation, mainstream deammonification and/or shortened nitrification-denitrification via nitrite (so-called “nitrite shunt”) is a new promising strategy. This study shows the mechanisms and operating conditions (e.g., dissolved oxygen (DO) concentration, temp.), leading to the complete domination of ammonium oxidizing bacteria (AOB) over nitrite oxidizing bacteria (NOB) under aerobic conditions. Its successful application as shortcut nitrification in the sequencing batch reactor (SBR) technology will represent a paradigm shift for the wastewater industry, offering the opportunity for efficient wastewater treatment, energy-neutral or even energy-positive facilities, and substantial reductions in treatment costs. In this study, under low and moderate temperatures (10–16 °C), averaged DO concentrations (0.7 mg O2/L) were preferable to ensure beneficial AOB activity over NOB, by maintaining reasonable energy consumption. Elevated temperatures (~30 °C), as well as increased DO concentration, were recognized as beneficial for the NOB activity stimulation, thus under such conditions, the DO limitation seems to be a more prospective approach.
Implementation Framework for Energy Flexibility Technologies in Alkmaar and Évora
Authors: Maas Nienke , Georgiadou Vasiliki , Roelofs Stephanie , Lopes Rui Amaral , Pronto Anabela , Martins João
Published: November 2020

As energy generation based on renewable resources does not always match energy consumption profiles, Positive Energy Districts (PEDs) should embody energy flexibility technologies to decrease possible negative impacts on existing grids due to, e.g., reverse power flows. As part of the EU H2020 Smart Cities and Communities project POCITYF, the cities Alkmaar (NL) and Évora (PT) aim to support the deployment and market uptake of such districts and in doing so demonstrate innovative and integrated technologies to enable flexibility in the energy system. This paper addresses implementation conditions for energy flexibility technologies that help cities to engender the expected impact and ensure replication of these technologies to other sites. It aims to guide both urban planners and technology solution providers through pitfalls and opportunities that can appear during the design and implementation of PEDs. Taking this into consideration, the RUGGEDISED innovation and implementation framework for smart city technology was taken as a starting point to describe and analyze the experiences in Alkmaar and Évora.
A Model for Cost–Benefit Analysis of Privately Owned Vehicle-to-Grid Solutions
Authors: Rodríguez-Molina Jesús , Castillejo Pedro , Beltran Victoria , Martínez-Núñez Margarita
Published: November 2020

Although the increasing adoption of electric vehicles (EVs) is overall positive for the environment and for the sustainable use of resources, the extra effort that requires purchasing an EV when compared to an equivalent internal combustion engine (ICE) competitor make them less appealing from an economical point of view. In addition to that, there are other challenges in EVs (autonomy, battery, recharge time, etc.) that are non-existent in ICE vehicles. Nevertheless, the possibility of providing electricity to the power grid via vehicle-to-grid technology (V2G), along with lower maintenance costs, could prove that EVs are the most economically efficient option in the long run. Indeed, enabling V2G would make EVs capable of saving some costs for their vehicle owners, thus making them a better long-term mobility choice that could trigger deep changes in habits of vehicle owners. This paper describes a cost–benefit analysis of how consumers can make use of V2G solutions, in a way that they can use their vehicle for transport purposes and obtain revenues when injecting energy into the power grid.
Bioclimatic Architecture and Urban Morphology. Studies on Intermediate Urban Open Spaces
Authors: Battisti Alessandra
Published: November 2020

This paper deals with the interactions between biophysical and microclimatic factors on the one hand with, on the other, the urban morphology of intermediate urban open spaces, the relationship between environmental and bioclimatic thermal comfort, and the implementation of innovative materials and the use of greenery, aimed at the users’ well-being. In particular, the thermal comfort of the open spaces of the consolidated fabrics of the city of Rome is studied, by carrying out simulations of cooling strategies relating to two scenarios applied to Piazza Bainsizza. The first scenario involves the use of cool materials for roofs, cladding surfaces, and pavement, while the second scenario, in addition to the cool materials employed in the first scenario, also includes the use of greenery and permeable green surfaces. The research was performed using summer and winter microclimatic simulations of the CFD (ENVI-met v. 3.1) type, in order to determine the different influences of the materials with cold colors, trees, and vegetated surfaces on the thermal comfort of the urban morphology itself. Meanwhile, the comfort assessment was determined through the physiological equivalent temperature (PET) calculated with the RayMan program. The first scenario, with the use of cool materials, improves summer conditions and reduces the urban heat island effect but does not eliminate thermal discomfort due to the lack of shaded surfaces and vegetation. The second scenario, where material renovations is matched with vegetation improvements, has a slightly bad effect on winter conditions but drastically ameliorates the summer situation, both for direct users and, thanks to the strong reduction of the urban heat island effect, to urban inhabitants as a whole.
Chestnut Shells as Waste Material for Succinic Acid Production from Actinobacillus succinogenes 130Z
Authors: Ventrone Michela , Schiraldi Chiara , Squillaci Giuseppe , Morana Alessandra , Cimini Donatella
Published: November 2020

Currently, the full exploitation of waste materials for the production of value-added compounds is one of the potential solutions to lower costs and increase the sustainability of industrial processes. In this respect, the aim of this work was to evaluate the potential of chestnut shells (CSH) as substrate for the growth of Actinobacillus succinogenes 130Z, a natural producer of succinic acid that is a precursor of several bulk chemicals with diverse applications, such as bioplastics production. Hydrolysis of ammonia pretreated CSH in citrate buffer with the Cellic CTec2 enzyme mix was optimized and strain performance was studied in bottle experiments. Data showed co-consumption of citrate, glucose and xylose, which resulted in a change of the relative ratio of produced acids, providing an insight into the metabolism of A. succinogenes that was never described to date. Furthermore, high C:N ratios seems to have a favorable impact on succinic acid production by decreasing byproduct formation. Finally, yield and volumetric production rate of succinic acid were studied in controlled 2 L bioreactors demonstrating the potential use of CSH as renewable raw material.
CYP6P9-Driven Signatures of Selective Sweep of Metabolic Resistance to Pyrethroids in the Malaria Vector Anopheles funestus Reveal Contemporary Barriers to Gene Flow
Authors: Djuicy Delia Doreen , Hearn Jack , Tchouakui Magellan , Wondji Murielle J. , Irving Helen , Okumu Fredros O. , Wondji Charles S.
Published: November 2020

Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we do not know if this resistance mechanism is spreading across Africa and how it relates to broader patterns of gene flow across the continent. Nucleotide diversity of the CYP6P9a gene and the diversity pattern of five gene fragments spanning a region of 120 kb around the CYP6P9a gene were surveyed in mosquitoes from southern, eastern and central Africa. These analyses revealed that a Cyp6P9a resistance-associated allele has swept through southern and eastern Africa and is now fixed in these regions. A similar diversity profile was observed when analysing genomic regions located 34 kb upstream to 86 kb downstream of the CYP6P9a locus, concordant with a selective sweep throughout the rp1 locus. We identify reduced gene flow between southern/eastern Africa and central Africa, which we hypothesise is due to the Great Rift Valley. These potential barriers to gene flow are likely to prevent or slow the spread of CYP6P9-based resistance mechanism to other parts of Africa and would to be considered in future vector control interventions such as gene drive.
Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study
Authors: Paterno Jussi J. , Koskela Ali , Hyttinen Juha M.T. , Vattulainen Elina , Synowiec Ewelina , Tuuminen Raimo , Watala Cezary , Blasiak Janusz , Kaarniranta Kai
Published: November 2020

Age-related macular degeneration is an eye disease that is the main cause of legal blindness in the elderly in developed countries. Despite this, its pathogenesis is not completely known, and many genetic, epigenetic, environmental and lifestyle factors may be involved. Vision loss in age-related macular degeneration (AMD) is usually consequence of the occurrence of its wet (neovascular) form that is targeted in the clinic by anti-VEGF (vascular endothelial growth factor) treatment. The wet form of AMD is associated with the accumulation of cellular waste in the retinal pigment epithelium, which is removed by autophagy and the proteosomal degradation system. In the present work, we searched for the association between genotypes and alleles of single nucleotide polymorphisms (SNPs) of autophagy-related genes and wet AMD occurrence in a cohort of Finnish patients undergoing anti-VEGF therapy and controls. Additionally, the correlation between treatment efficacy and genotypes was investigated. Overall, 225 wet AMD patients and 161 controls were enrolled in this study. Ten SNPs (rs2295080, rs11121704, rs1057079, rs1064261, rs573775, rs11246867, rs3088051, rs10902469, rs73105013, rs10277) in the mTOR (Mechanistic Target of Rapamycin), ATG5 (Autophagy Related 5), ULK1 (Unc-51-Like Autophagy Activating Kinase 1), MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 α), SQSTM1 (Sequestosome 1) were analyzed with RT-PCR-based genotyping. The genotype/alleles rs2295080-G, rs11121704-C, rs1057079-C and rs73105013-T associated with an increased, whereas rs2295080-TT, rs2295080-T, rs11121704-TT, rs1057079-TT, rs1057079-T, rs573775-AA and rs73105013-C with a decreased occurrence of wet AMD. In addition, the rs2295080-GG, rs2295080-GT, rs1057079-TT, rs11246867-AG, rs3088051-CC and rs10277-CC genotypes were a positively correlated cumulative number of anti-VEGF injections in 2 years. Therefore, variability in autophagy genes may have an impact on the risk of wet AMD occurrence and the efficacy of anti-VEGF treatment.
Coronavirus Disease 2019 (COVID-19): A Modeling Study of Factors Driving Variation in Case Fatality Rate by Country
Authors: Pan Jennifer , St. Pierre Joseph Marie , Pickering Trevor A. , Demirjian Natalie L. , Fields Brandon K.K. , Desai Bhushan , Gholamrezanezhad Ali
Published: November 2020

Background: The novel Severe Acute Respiratory Syndrome Coronavirus-2 has led to a global pandemic in which case fatality rate (CFR) has varied from country to country. This study aims to identify factors that may explain the variation in CFR across countries. Methods: We identified 24 potential risk factors affecting CFR. For all countries with over 5000 reported COVID-19 cases, we used country-specific datasets from the WHO, the OECD, and the United Nations to quantify each of these factors. We examined univariable relationships of each variable with CFR, as well as correlations among predictors and potential interaction terms. Our final multivariable negative binomial model included univariable predictors of significance and all significant interaction terms. Results: Across the 39 countries under consideration, our model shows COVID-19 case fatality rate was best predicted by time to implementation of social distancing measures, hospital beds per 1000 individuals, percent population over 70 years, CT scanners per 1 million individuals, and (in countries with high population density) smoking prevalence. Conclusion: Our model predicted an increased CFR for countries that waited over 14 days to implement social distancing interventions after the 100th reported case. Smoking prevalence and percentage population over the age of 70 years were also associated with higher CFR. Hospital beds per 1000 and CT scanners per million were identified as possible protective factors associated with decreased CFR.
Waste Separation Behaviour of College Students under a Mandatory Policy in China: A Case Study of Zhengzhou City
Authors: Hao Mengge , Zhang Dongyong , Morse Stephen
Published: November 2020

The need for effective solid waste management (SWM) is an important environmental and public health issue. As a key way of minimizing municipal solid waste (MSW), source separation has in recent years become the centre of discussion in China. Following the example of Shanghai, the city of Zhengzhou introduced its mandatory waste separation measures on 1 December 2019. But does the mandatory regulation work? This study aims to investigate the waste separation behaviour of college students in Zhengzhou under the mandatory regulation and the motivations behind students’ behaviour. A questionnaire-based survey was carried out on 62 university campuses in Zhengzhou City, and a total of 1747 valid questionnaires were completed across these campuses and analysed. It was found that under Zhengzhou’s mandatory measures, college students do have a basic knowledge of waste separation and most are familiar with where kitchen waste should be placed, but they have problems categorizing some recyclables such as glass, hazardous waste such as lightbulbs and other waste such as cigarette butts and napkins. It was also found that college students’ waste separation behaviour, their attitude towards waste separation and the convenience of waste sorting facilities in Zhengzhou in the mandatory era have been improved compared to the era prior to mandatory waste separation. The results also indicate that most of college students (86.7%) always or sometimes undertake waste separation, and students majoring in science and senior year undergraduates are more likely to participate in the practice of waste separation. Other influencing factors of college students’ waste separation behaviour include convenience of waste sorting facilities, their willingness to separate waste, knowledge of a related field, attitude towards waste separation, peer pressure as well as the existence of a reward and penalty system. Management strategies for improving college students’ waste separation behaviour under mandatory regulation are also discusses and a number of recommendations for improvement are made.
The Effect of Boarding on the Mental Health of Primary School Students in Western Rural China
Authors: Tang Bin , Wang Yue , Gao Yujuan , Wu Shijin , Li Haoyang , Chen Yang , Shi Yaojiang
Published: November 2020

Based on the panel data of 20,594 fourth- and fifth-grade students in the western provinces A and B in China, this paper analyzed the effect of boarding at school on the mental health of students using a combination of the propensity score matching (PSM) and difference-in-differences (DID) methods. The results showed that boarding had no significant effect on the mental health of students, but the tendency of loneliness among boarding school students was increased. Heterogeneity analysis found that fifth-grade students whose parents had both left home to work were more likely to have poorer mental health when boarding. This paper has essential policy significance for guiding rural primary schools to improve the mental health of boarding school students, especially left-behind children.
Relationship of Internet Gaming Disorder with Psychopathology and Social Adaptation in Italian Young Adults
Authors: De Pasquale Concetta , Sciacca Federica , Martinelli Valentina , Chiappedi Matteo , Dinaro Carmela , Hichy Zira
Published: November 2020

Internet addiction is currently considered a worldwide problem, with a possible impact on mental health. This study aimed to investigate the prevalence of internet gaming disorder (IGD) among Italian young adults and to explore its association with psychopathological symptoms. Our sample included 566 young adults (324 males/242 females; age: 22.74 ± 4.83 years). Participants were asked to state their favorite games and complete the following questionnaires: the Internet Gaming Disorder Scale Short Form (IGD9-SF); the APA symptom checklist, based on DSM-5 diagnostic criteria for IGD; the Symptom Checklist-90 Revised (SCL-90 R); and the Social Adaptation Self Evaluation Scale (SASS). Use of video games was common among study participants (95% of the sample). Thirty subjects (5.3% of the sample) matched criteria for a clinical diagnosis of IGD. Data showed a positive correlation between higher use of online games and higher levels of depression (r = 0.501), anxiety (r = 0.361) and psychoticism (r = 0.431), and lower family and extra-family relationships (r = −0.383). At linear regression analysis, somatization (p = 0.002), depression (p = 0.001) and sleep disturbances (p = 0.003) were predictors of IGD diagnosis. IGD was significantly associated to mental health distress. Healthcare professionals should be aware of the problematic consequences of online gaming.