bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety and Clinical Activity of a New Anti-PD-L1 Antibody as Monotherapy or Combined with Targeted Therapy in Advanced Solid Tumors: The PACT Phase Ia/Ib Trial
Authors: Patnaik Amita , Yap Timothy A. , Chung Hyun Cheol , de Miguel Maria J. , Bang Yung-Jue , Lin Chia-Chi , Su Wu-Chou , Italiano Antoine , Chow Kay Hoong , Szpurka Anna M. , Yu Danni , Zhao Yumin , Carlsen Michelle , Schmidt Shelly , Vangerow Burkhard , Gandhi Leena , Xu Xiaojian , Bendell Johanna
Published: November 2020

Purpose:

This phase Ia/Ib PACT study evaluated the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of a new programmed cell death ligand 1 (PD-L1) inhibitor, LY3300054, as monotherapy or in combination with ramucirumab, abemaciclib, or merestinib (a type II MET kinase inhibitor) in patients with advanced, refractory solid tumors (NCT02791334).

Patients and Methods:

Patients were enrolled into cohorts of escalating LY3300054 dose (phase Ia) as monotherapy (N = 15) or combined with ramucirumab (N = 10), abemaciclib (N = 24), or merestinib (N = 12). The phase Ib dose expansion enrolled 8 patients with melanoma in the monotherapy arm and 12 patients with pancreatic cancer in the merestinib combination arm. Combination treatments were administered concurrently from day 1 of each cycle. A 14-day lead-in abemaciclib arm was also explored. Primary endpoints were dose-limiting toxicity (DLT) and safety.

Results:

Treatment-related adverse events included fatigue and nausea in the monotherapy arm (13% for each), hypothyroidism (30%) in the ramucirumab arm, diarrhea (54%) in the abemaciclib arm, and nausea (25%) in the merestinib arm. DLTs associated with hepatoxicity were observed in 3 of 4 patients in the abemaciclib lead-in cohorts. No DLTs or grade 3 or 4 hepatoxicity were reported in the concurrent abemaciclib arm. Pharmacokinetic characteristics were comparable with other PD-L1 inhibitors. One patient in each arm experienced a partial response per RECIST v1.1 lasting ≥7 months.

Conclusions:

LY3300054 was well tolerated without unexpected safety concerns when administered alone or concurrently with ramucirumab, abemaciclib, or merestinib. Lead-in abemaciclib before combining with LY3300054 was not feasible due to hepatotoxicity. Durable clinical benefits were seen in all regimens.
Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma
Authors: Hitchman Tyler D. , Bayshtok Gabriella , Ceraudo Emilie , Moore Amanda R. , Lee Cindy , Jia Ruobing , Wang Naitao , Pachai Mohini R. , Shoushtari Alexander N. , Francis Jasmine H. , Guan Youxin , Chen Juliet , Chang Matthew T. , Taylor Barry S. , Sakmar Thomas P. , Huber Thomas , Chi Ping , Chen Yu
Published: November 2020

Purpose:

All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the G-protein alpha-q (Gαq) pathway. Targeting these melanomas has proven difficult despite advances in the molecular understanding of key driver signaling pathways in the disease pathogenesis. Inhibitors of Gαq have shown promising preclinical results, but their therapeutic activity in distinct Gαq mutational contexts and in vivo have remained elusive.

Experimental Design:

We used an isogenic melanocytic cellular system to systematically examine hotspot mutations in GNAQ (e.g., G48V, R183Q, Q209L) and CYSLTR2 (L129Q) found in human uveal melanoma. This cellular system and human uveal melanoma cell lines were used in vitro and in in vivo xenograft studies to assess the efficacy of Gαq inhibition as a single agent and in combination with MEK inhibition.

Results:

We demonstrate that the Gαq inhibitor YM-254890 inhibited downstream signaling and in vitro growth in all mutants. In vivo, YM-254890 slowed tumor growth but did not cause regression in human uveal melanoma xenografts. Through comprehensive transcriptome analysis, we observed that YM-254890 caused inhibition of the MAPK signaling with evidence of rebound by 24 hours and combination treatment of YM-254890 and a MEK inhibitor led to sustained MAPK inhibition. We further demonstrated that the combination caused synergistic growth inhibition in vitro and tumor shrinkage in vivo.

Conclusions:

These data suggest that the combination of Gαq and MEK inhibition provides a promising therapeutic strategy and improved therapeutic window of broadly targeting Gαq in uveal melanoma.

See related commentary by Neelature Sriramareddy and Smalley, p. 1217
Pediatric Acute Kidney Injury to the Subsequent CKD Transition
Authors: Wang Fang , Ding Jie
Published: November 2020

Background: Both acute kidney injury (AKI) and CKD are complex syndromes caused by multiple etiologies and presented with various degrees of severity. Studies on adults provide strong evidence that AKI is an independent risk factor for both the initiation and progression of CKD, and the severity, frequency, and duration of AKI are crucial factors in the subsequent development of CKD. However, without consensus definitions of AKI and CKD and long-term follow-up studies using predictive biomarkers, it is difficult to clarify the potential for transition from AKI to CKD in pediatric populations. The goal of this review is to describe the most recent studies in epidemiology of pediatric AKI and biomarkers aiding in the earlier detection of AKI and CKD. Summary: KDIGO criteria for AKI have been widely applied for pediatric AKI studies. AKI in critically ill and non-critically ill children is common. CKD is highly prevalent in pediatric AKI survivors. Compared with traditional biomarkers such as serum Cr, proteinuria, and estimated glomerular filtration rate, urinary biomarkers earlier identifying AKI may also detect CKD earlier, but additional studies are required to determine their clinical utility. Key Messages: The use of consensus AKI criteria has improved our understanding of pediatric AKI epidemiology, and an association between AKI and CKD in pediatric populations has been endorsed. However, further studies are needed to better answer a definitive causal relationship between pediatric AKI and the subsequent development of CKD.
Accuracy and Safety of Customized Stereotactic Fixtures for Stereoelectroencephalography in Pediatric Patients
Authors: Pistol Constantin , Daneasa Andrei , Ciurea Jean , Rasina Alin , Barborica Andrei , Oane Irina , Mindruta Ioana
Published: November 2020

Stereoelectroencephalography (SEEG) in children with intractable epilepsy presents particular challenges. Their thin and partially ossified cranium, specifically in the temporal area, is prone to fracture while attaching stereotactic systems to the head or stabilizing the head in robot’s field of action. Postponing SEEG in this special population of patients can have serious consequences, reducing their chances of becoming seizure-free and impacting their social and cognitive development. This study demonstrates the safety and accuracy offered by a frameless personalized 3D printed stereotactic implantation system for SEEG investigations in children under 4 years of age. SEEG was carried out in a 3-year-old patient with drug-resistant focal epilepsy, based on a right temporal-perisylvian epileptogenic zone hypothesis. Fifteen intracerebral electrodes were placed using a StarFix patient-customized stereotactic fixture. The median lateral entry point localization error of the electrodes was 0.90 mm, median lateral target point localization error was 1.86 mm, median target depth error was 0.83 mm, and median target point localization error was 1.96 mm. There were no perioperative complications. SEEG data led to a tailored right temporal-insular-opercular resection, with resulting seizure freedom (Engel IA). In conclusion, patient-customized stereotactic fixtures are a safe and accurate option for SEEG exploration in young children.
Magnetic Resonance Imaging in Stable Mild Cognitive Impairment, Prodromal Alzheimer’s Disease, and Prodromal Dementia with Lewy Bodies
Authors: Siddiqui Tahreem Ghazal , Whitfield Timothy , Praharaju Sudhakar Janaki , Sadiq Dilman , Kazmi Hiba , Ben-Joseph Aaron , Walker Zuzana
Published: November 2020

Introduction: Fifteen percent of people with mild cognitive impairment (MCI) will progress to dementia within 2 years. There is increasing focus on the evaluation of biomarkers which point towards the underlying pathology. This enables better prediction of clinical outcomes. Early diagnosis of the dementia subtype is crucial for appropriate management and accurate prognosis. The aim of this study was to compare MRI measures in stable mild cognitive impairment patients (stable-MCI), prodromal Alzheimer’s disease (pro-AD), and prodromal dementia with Lewy bodies (pro-DLB). Methods: Out of 1,814 patients assessed in Essex memory clinic between 2002 and 2017, 424 had MCI at baseline with follow-up data. All patients underwent comprehensive clinical and cognitive assessment at each assessment. MRI scans were acquired at patients’ baseline assessment, corresponding to the time of initial MCI clinical diagnosis. Patients were grouped according to their diagnosis at the end of follow-up. All baseline scans were visually rated according to established rating scales for medial temporal atrophy (MTA), global cortical atrophy (GCA), and white matter lesions (WMLs). Results: MRI scans were available for 28 pro-DLB patients and were matched against 27 pro-AD and 28 stable-MCI patients for age, sex, and education. The mean follow-up duration was 34 months for the pro-AD group, 27 months for the pro-DLB group, and 21 months for the stable-MCI group. MTA scores were significantly greater in pro-AD patients compared to pro-DLB (p = 0.047) and stable-MCI patients (p = 0.012). There was no difference on GCA or WMLs between pro-AD, pro-DLB, and stable-MCI. Conclusions: This study indicates that a simple visual rating of MTA at the stage of MCI already differs at a group level between patients that progress to AD, DLB, or continue to be stable-MCI. This could aid clinicians to differentiate between MCI patients who are likely to develop AD, versus those who might progress to DLB or remain stable.
Cutaneous Myiasis Caused by Chrysomya megacephala in an Infant with Psoriasis Vulgaris
Authors: Sangmala Siripan , Aiempanakit Kumpol , Khantee Puttichart , Pengsakul Theerakamol
Published: November 2020

Cutaneous myiasis is an infestation of the skin by fly larvae, which usually occurs in adults. We present a case of cutaneous myiasis caused by Chrysomya megacephalain a 3-month-old infant with psoriasis vulgaris. In this case report, we highlight the clinical, histopathologic, taxonomic identification, and treatment of cutaneous myiasis occurring in psoriatic skin.
Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism
Authors: Abbara Ali , Eng Pei Chia , Phylactou Maria , Clarke Sophie A. , Mills Edouard , Chia Germaine , Yang Lisa , Izzi-Engbeaya Chioma , Smith Neil , Jayasena Channa N. , Comninos Alexander N. , Anand-Ivell Ravinder , Rademaker Jesse , Xu Cheng , Quinton Richard , Pitteloud Nelly , Dhillo Waljit S.
Published: November 2020

Background: Hypogonadotropic hypogonadism (HH) is hypogonadism due to either hypothalamic or pituitary dysfunction. While gonadotropin-releasing hormone (GnRH) can directly test pituitary function, no specific test of hypothalamic function exists. Kisspeptin-54 (KP54) is a neuropeptide that directly stimulates hypothalamic GnRH release and thus could be used to specifically interrogate hypothalamic function. Congenital HH (CHH) is typically due to variants in genes that control hypothalamic GnRH neuronal migration or function. Thus, we investigated whether KP54 could accurately identify hypothalamic dysfunction in men with CHH. Methods: Men with CHH (n = 21) and healthy eugonadal men (n = 21) received an intravenous bolus of either GnRH (100 μg) or KP54 (6.4 nmol/kg), on 2 occasions, and were monitored for 6 h after administration of each neuropeptide. Results: Maximal luteinizing hormone (LH) rise after KP54 was significantly greater in healthy men (12.5 iU/L) than in men with CHH (0.4 iU/L; p < 0.0001). KP54 more accurately differentiated CHH men from healthy men than GnRH (area under receiver operating characteristic curve KP54: 1.0, 95% CI 1.0–1.0; GnRH: 0.88, 95% CI 0.76–0.99). Indeed, all CHH men had an LH rise <2.0 iU/L following KP54, whereas all healthy men had an LH rise >4.0 iU/L. Anosmic men with CHH (i.e., Kallmann syndrome) had even lower LH rises after KP54 than did normosmic men with CHH (p = 0.017). Likewise, men identified to have pathogenic/likely pathogenic variants in CHH genes had even lower LH rises after KP54 than other men with CHH (p = 0.035). Conclusion: KP54 fully discriminated men with CHH from healthy men. Thus, KP54 could be used to specifically interrogate hypothalamic GnRH neuronal function in patients with CHH.
Identity formation: An auto-ethnography of Indonesian student becomes a legitimate speaker and teacher of English
Authors: Sarie Rina Febriani , Pratolo Bambang Widi , Purwanti Eko
Published: November 2020

Several studies have investigated how the TESOL program influenced the construction of Non-Native English Speaker Teachers’ identities, yet few literature concerns about the negotiation of NNESTs’ identity as legitimate speakers and teachers of English. This paper was an auto-ethnographic investigation of my personal experience as one of international students in the TESOL program at an Australian university. Drawing on Norton’s theory of language and identity, this study examined a complex process of my identity formation as a legitimate speaker and teacher of English after studying one of a critical pedagogical unit ‘Language, Culture, and Curriculum’. The findings revealed that the TESOL program enabled me to discover and explore another part of myself as a legitimate speaker and teacher of English through linguistic constructs and rich knowledge given in that unit. It also supported that a critical pedagogical unit could empower international students to form their identities as confident and professional English teachers back to their countries.
How classroom design impacts for student learning comfort: Architect perspective on designing classrooms
Authors: Widiastuti Kurnia , Susilo Mohamad Joko , Nurfinaputri Hanifah Sausan
Published: November 2020

This study aimed to determine the factors that influence student learning comfort in the classroom and its distribution. This explorative study employed 772 students who were elementary school, junior high school, and senior high school students in several Muhammadiyah Yogyakarta schools. Data collection techniques using open questionnaires. The data analysis technique uses qualitative analysis which consists of three stages: open coding, axial coding, and selective coding. The results showed that the factors that influence learning comfort of students in the classroom include: air circulation, quietness, cleanliness, adequate & supportive facilities, and peer attendance. These five factors are among other factors that are grouped into two: 1) factors originating from the physical environment (of building & site themes and of indoor space themes); and 2) factors from within its occupants (of human themes). The theme that shows the highest influence comes from the physical conditions in the classroom, that is indoor space themes.
Competency improvement through internship: An evaluation of corporate social responsibility program in vocational school
Authors: Ramadhani Mgs. Ahmad , Rahayu Ety
Published: November 2020

The high unemployment rate in Indonesia derived from vocational school graduates could be alleviated through internship as a part of Corporate Social Responsibility program that deployed by company together with school to equip its students or graduates with set of competences, therefore they will be competent and able to compete in job market, especially in the era of disruptive technologies. This applied research of evaluation using qualitative approach aimed to evaluate the input and process of the corporate social responsibility program in vocational internship conducted by an oil and gas manufacturing company in Indonesia. The results of this revealed some inputs that were the source of program success and processes that determined the quality of the program. Aspects of input generally met the ideal criteria such as competent program staff, participant characteristic reflecting program objectives, flexible and synchronized curriculum, adequate facility, and available procedure. Aspects of the process complied with regulations and procedures as well. Both aspects resulted the achievement of outcome that exceeded expectation such as competence improvement, cost saving, awards and provide information to be replicated by other institutions.
A systematic review of photovoice as participatory action research strategies
Authors: Suprapto Nadi , Sunarti Titin , Suliyanah Suliyanah , Wulandari Desi , Hidayaatullaah Hasan Nuurul , Adam Alif Syaiful , Mubarok Husni
Published: November 2020

Photovoice research is conducted by researchers to communicate images or photographs, and it has high confidence in analyzing the value, story or meaning of an image. Several previous studies that examined photovoice as a research strategy were analyzed and reviewed. This systematic review used an article selection process. It was defining the purpose, conducting a literature search, pulling articles by reading abstracts, reading the full paper, data abstraction, and conducting an analysis. The photovoice article selection was classified into education, health, and social science domain. Finally, forty-one articles have been reviewed with the total of participants involved ranged from five to fifty individuals. The majority of research method in the articles was participatory action research (PAR) through qualitative inquiry or field visits. Meanwhile, the research instruments used photography, documentation, observation, and interviews. In various fields of research, photovoice is able to increase the understanding of individuals or groups to interpret the content of an image or photo.
Mathematical self-concept among prospective teachers
Authors: Takaria Johannis , Palinussa Anderson Leonardo
Published: November 2020

Mathematical self-concept (MS-C) is an important construct that prospective mathematics teachers must have in mathematics learning. The aim of the research was to analyze the increase of MS-C of prospective mathematics teachers. The research was quasi-experimental with the design of one group pretest-posttest. The results showed that for prospective teachers, MS-C increased in the medium category while the MS-C indicators achieved in the medium and low categories. The increase of MS-C is due to the effectiveness of collaborative mind mapping (CMM) learning strategy and the process of strengthening MS-C capacity of prospective teachers. The CMM facilitates prospective teachers to construct creative ideas through structured collective ideas that support the increase of MS-C among prospective teacher.
Question-led approach in designing Dijkstra algorithm game-based learning: A pilot study
Authors: Ramle Rosni Binti , Rosli D’oria Islamiah , Nathan Shelena Soosay , Berahim Mazniha
Published: November 2020

Dijkstra algorithm is important to be understood because of its many uses. However, understanding it is challenging. Various methods to teach and learn had been researched, with mixed results. The study proposes questionled approach of the algorithm in a game-based learning context. The game designed based on an existing game model, developed and tested by students. Pre- and post-game tests compared and game feedback survey analysed. Results showed that students’ performance in graph data structure Dijkstra algorithm improved after playing the game where post-test mark was higher than pre-test. Game feedback were mostly positive, with areas of improvement. Students may use the game as a learning tool for self-regulated learning. Educators may get some ideas on how to design teaching tool using question-led approach.
TPACK in ASEAN perspectives: Case study on Thai pre-service teacher
Authors: Nuangchalerm Prasart
Published: November 2020

Technological Pedagogical and Content Knowledge (TPACK) is now recognizing for teacher development and preparation program. The new era of teaching and learning are not only focus on contents, but also pedagogical knowledge, technology and education with instructional strategies are now necessary for teacher preparation program. This study focuses on identifying and summarizing the features of TPACK in ASEAN literatures. The review was conducted using the ACI database; a total of 11 articles describing TPACK based on specific search criteria. The framework of TPACK needs to generalize to school policy, administrative purposes and teacher development and teacher preparation program. Also, the exploratory TPACK of 7 Thai pre-service science teachers in one-year school practicum provided significant findings through TPACK questionnaire and lesson plan analysis. Data were collected and analyzed by descriptive analysis. The explorative study illustrated the nature of their TPACK by concept and practice was at high level. The study needs pre-service teacher have technology integration in teacher preparation program, also TPACK should be implemented in teacher development program.
Emotional exhaustion and organizational commitment: Primary school teachers’ perspective
Authors: Wullur Mozes M. , Werang Basilius Redan
Published: November 2020

Teaching is a noble profession to educate the youth of nations facing today’s global challenges. Teaching, at the same time, has become a highly challenging profession and occasionally a draining work, especially for those who are working in the remote areas. A high-level of teacher absenteeism in the primary schools of Southern Papua has blown some societal alarm for conducting studies focusing on emotional exhaustion as a latent predictor for low-performance. This study attempted to describe the eventual correlation between the emotional exhaustion and organizational commitment of teachers working in the primary schools of Merauke, Indonesia. A survey approach was employed to collect data from a total of 243 primary school teachers in Merauke, Papua, Indonesia. Data were examined statistically by employing Pearson’s correlation model. Results of analysis showed that the emotional exhaustion and commitment of primary school teachers in Merauke, Indonesia, are significantly negatively correlated. This result may be useful for the teachers to benefit from the information of how they may interact with all the school elements and the extent to which these emotions directly affect their organizational commitment. The result may also be advisable for the school leaders to take some tactical efforts of securing teachers’ emotion to promote a high-level of teachers’ organizational commitment and, in turn, improving students’ capabilities in reading, writing, and arithmetics.
Experiences and satisfaction of high-risk mothers who gave birth in select facilities in Legazpi City, Philippines
Authors: Cagayan MD Maria Stephanie Fay S. , Christian F. Pepito Veincent , Bon MD MPM Rita Mae Ang , Llamas-Clark Erlidia F.
Published: November 2020

Among the interventions implemented to curb maternal mortality in the Philippines, service delivery networks (SDNs) have been one of the most important. However, due to their recent implementation, frameworks to assess the quality of care they provide have not yet been established. To address this need, we had formulated the Integrated Patient-Centered Health Service Framework and used it to explore the satisfaction of mothers who gave birth in select facilities Legazpi City Philippines. We conducted key-informant interviews with 14 mothers. We found out that they were satisfied with the quality of care during pre-pregnancy, pregnancy, and post-partum; however, the quality of care during labor and delivery, adherence to referral protocols, and respect for patient‟s autonomy can still be improved. The framework should be used by program managers to have a qualitative measure of quality of care provided by SDNs, as well as to ensure that referral protocols were implemented.
Predictors of stunting among pediatric children living with HIV/AIDS, Eastern Ethiopia
Authors: Gezahegn Dawit , Egata Gudina , Gobena Tesfaye , Abebaw Berhanu
Published: November 2020

Globally, there were about 3.4 million pediatric children (<15 years of age) who were living with HIV/AIDS. Ethiopia has one of the highest rates of malnutrition in Sub-Saharan Africa. As of 2013, there were about 160,000 pediatric children living with HIV/AIDS in Ethiopia. Even though undernutrition makes it difficult to combat HIV/AIDS, there is paucity of information on the magnitude of stunting and its predictors among seropositive pediatric children in low-income countries like Ethiopia. Institution based quantitative cross sectional study design was employed on 414 randomly selected pediatric (5-15 years) children living with HIV/AIDS in Harari Region and Dire Dawa City Administration Public Hospitals, Eastern Ethiopia. Pretested interviewer administered questionnaire and patient card review was held to collect data. Data were entered through Epi-data and exported to SPSS for analysis. The WHO Anthros plus software was used to calculate the anthropometric indices. Bivariate and Multivariable analysis along with 95%CI were done to identify predictors of stunting. Level of statistical significance was declared at P-value <0.05. The prevalence of stunting was found to be 30.9% (95%CI: 26.0-36.0%). Rural residence [AOR=4.0, (95%CI: 2.22, 7.17)], family monthly income of ≤500 ETB [AOR=5.79, (95%CI: 2.82, 11.60)], being anemic [AOR=3.17, (95% CI: 2.13, 4.93)] and the presence of diarrhea [AOR=6.21, 95% (CI: 3.39, 9.24)] were predictors of stunting. Thus, collaborative measures should be undertaken (to decrease frequent infections and to improve the economic status) to combat chronic malnutrition during HIV/AIDS treatment.
Contamination rate of commonly consumed fresh vegetables and fruits with parasites of medically importance in Wolkite and Butajira Towns of Gurage Zone, Southern Ethiopia
Authors: Bekele Fitsum , Shumbej Teha , Dendir Andamlak , Mesfin Dereje , Solomon Absra
Published: November 2020

Intestinal parasitic infections are among the most common on causes  of disease in humans, responsible for considerable morbidity and mortality. Commonly consumed raw vegetables and fruits are among the ways through which humans become infected with parasites of medical importance. A prospective cross-sectional study with an aim of describing the parasite contamination rate of raw fresh vegetables and fruits sold at the central open-aired market of Butajira and Wolkite towns, in southern Ethiopia was conducted on a total of 270 fresh vegetable and fruits samples. Standardized parasitological techniques were employed to detect diagnostic stages of parasites.98 out of the 270 (36.3%) samples were found positive for intestinal parasites. Remarkably, twenty eight out of the forty five cabbage samples analyzed, 62.2%, were found to be contaminated with parasites of medical importance, registering the highest level of contamination. On the contrary Avocado was found to be the least contaminated produce with contamination rate of 17.7% (8/45). Significant association was observed between the kind of vegetables analyzed and existence of parasites (p=0.002). This study identified high rate of contamination in commonly consumed vegetables and fruits. The authors believe that the role fruits and vegetables paly in the transmission of intestinal parasitic infections to humans is un questionable. Substantial attention is needed from all relevant bodies to tackle this problem.
Stress and fear in women living with cancer: An argumentation towards the adaptation theory
Authors: Sari Ni Putu Wulan Purnama
Published: November 2020

Extended life expectancy in cancer nowadays has implication on longer exposures toward cancer-related stressors. Based on the adaptation theory, the longer the stressor exposures then the more the stress tolerance expected. This study aimed to compare and analyze the differences of stress and fear in cervical and breast cancer survivors (CCS and BCS) between cases and survivorship stages, impacting on anxiety, depression, and perceived life normality (PLN). This cross-sectional study involved 47 CCS and 58 BCS (n=105). Self-developed instrument was used in data collection (r=-0.256-0.935; Chronbach’s Alpha=0.908). Various statistical tests were used in data analysis (α<0.05). Stress due to cancer diagnosis and treatments were significantly different between cases (p=0.005 and p=0.003 in CCS and BCS respectively), impacting significant differences on anxiety, depression, and PLN between cases (p=0.025, p=0.000, and p=0.000 respectively). In both cases, stress due to cancer diagnosis and treatments, anxiety, depression, and PLN were not significantly different between survivorship stages (all p>0.05). Fear towards cancer recurrence, metastasis, additional cancer, and diagnostic test were not significantly different between cases and survivorship stages (all p>0.05). These findings argue the adaptation theory because the adaptation process was proved to be limitless in CCS and BCS; therefore it can’t be seen as a product.
Nutritional status of under-five children in rural Bangladesh
Authors: Sen Liton Chandra , Ahmed Md. Sabbir , Touhiduzzaman Abu Shoeb Md. , Mandal Soumitra , Ahmed AH Towfique , Das Sanjit Kumar , Saha Rama
Published: November 2020

A cross-sectional study was carried out in Dumki Upazila of Patuakhali district in Bangladesh to assess the prevalence of stunting, wasting and underweight among the under-five children. Anthropometric measurements were taken from all children, aged 0-59 months in the studied area using wooden height board and digital weight machine. We used WHO Anthro software for analyzing the z scores of the children. A total of 4409 (2296 boys and 2113 girls) under five children were counted for anthropometric analysis.  Regarding the Height-for-age Z-score (HAZ), the study revealed that the prevalence of stunting was 27.10% (95% CI: 25.8-28.5) of the children while 7.80% (95% CI: 7-8.6) were severe stunting. By assessing the Weight-for-height Z-score (WHZ), the study showed that 11.20% (95% CI: 10.3-12.1) were wasting whereas 3% (95% CI 2.5-3.5) were severe wasting. According to Weight-for-age Z-score (WAZ), about 18.20% (95% CI: 17-19.3) were underweight and 4.1% (95% CI: 3.5-4.7) were underweight. The findings of the study show that prevalence of stunting is very high. Focusing on childhood stunting is a high priority, and there should be comprehensive efforts to increase the overall nutritional status of the under-five children in this area.
Clinical pharmacoepidemiology of antibiotics usage in intensive care unit of cancer special hospital
Authors: Akrom Akrom , Capritasari Rafiastiana
Published: November 2020

The pattern of antibiotics use in cancer patients in the intensive care unit (ICU) of dharma is cancer special hospital (DCSH) has not been identified. The purpose of this study is to determine the pattern of antibiotics use in cancer patients treated in the ICU of DCSH from 2012-2014. This study was observational with a cross-sectional design. The data collection is done retrospectively. The inclusion criteria to recruit the subjects, i.e. Adult patients who had nosocomial infections in the ICU; Patients with medical records in the ICU who received antibiotics in the 2012-2014 periods. Patients originating from inpatients (wards); Patients with medical records were read. The exclusion criteria were postoperative patients and Patients with incomplete medical records. We collected data from medical records of cancer patients who had been admitted to the ICU in 2012-2014, medication administration records, sample submission, and laboratory records. There are 202 cancer patients including in the study. Leukemia and breast cancer were the most cancer’s diagnosis in the Subject. More than two hundred cancer patients were receiving antibiotic therapy, with more than 50% of them were diagnosed with pneumonia, followed by central infection (>20%) and urinary tract infection (>10%). The antibiotic most frequently used was meropenem, with 33.8%. The three most commonly used antibiotics from 2012 to 2014 were meropenem, levofloxacin, and ceftriaxone.
Hormonal profile and characteristics of polychistic ovarium syndrome among Madurese tribe, Indonesia
Authors: Zainiyah Zakkiyatus , Susanti Eny , Haris Mustofa
Published: November 2020

Polycystic ovarium syndrome (PCOS), the most common endocrine disorders in women of reproductive age, characterized by menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, the appearance of acne, alopecia and the results of biochemical tests that show increased androgens (testosterone). Increased serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) serve as diagnostic tests for PCOS over the years, but from several research results obtained inconsistent results that need further research. The purpose of this study is to analyze the hormonal profile and characteristics of polycystic ovary syndrome (PCOS) in Madura. Case-control study conducted in March-August 2019 in the Madura tribe. There were 32 subjects with PCOS and 32 healthy women participated in this study. Hormonal examination was using a serum and followed by enzyme-linked immune sorbent assay (ELISA kit). Levels Follicle-stimulating hormone (FSH) average was 8.74 and SHBGs were 10.02 lower in PCOS patients and LH levels were higher in PCOS patients; ratio LH/FSH was 0.76. The results of the Madurese study showed that levels of FSH, LH, weight significantly related to PCOS sex hormone binding globulin (SHBG), however body mass index (BMI) levels were not related to PCOS.
Prevalence and determinants of overweight and obesity among school-aged children and adolescents
Authors: Wanghi Guy Ikambo , Leytle Leslie , Kabututu Zakayi Pius , Buhendwa Augustin Rudahaba , Sumaili Kiswaya Ernest
Published: November 2020

Obesity is a significant public health crisis affecting millions of children globally. The objective of this study was to identify the prevalence and associated factors of overweight/obesity among school children in Kinshasa, Democratic Republic of Congo (DRC). This was a descriptive cross-sectional study among school children and adolescents
(n= 1442) from Kinshasa selected using multistage sampling method. A structured questionnaire was used to collect behavioral data. The WHO AnthroPlus was used to calculate BMI (body mass index). SPSS version 21 was used for data analysis. Potential covariates were examined using chi-square tests followed by multivariate logistic regression analyzes The study found that out of 1442 students, 72% of the sample was at a healthy weight, 15% were underweight and nearly 13% were overweight or obese. The prevalence of overweight and obesity was higher in girls as compared with boys. The results of multivariate logistic regressions showed that the gender of children, category of age, percent body fat, eating fruits and vegetables, and physical activity levels were significantly associated with childhood overweight/obesity. One in eight children and adolescents (12.8%) aged 6 to 18 years in Kinshasa going to primary and secondary schools were either overweight or obese.
Barrier and facilitator on breastfeeding education and promotion: A literature review
Authors: Handayani Lina , Dewi Maya Kusuma , Munira Lafi
Published: November 2020

Breast milk contains many nutrients according to the needs of the baby for growth and development. Breast milk is very important for the health and well-being of infants. The world health organization recommends exclusive breastfeeding mothers for six months starting from the baby's first life and continuing until the age of two. Breastfeeding can provide economic benefits for the family and community. This study aimed to explore the barrier and facilitator on breastfeeding promotion and education. This study was literature study. This study finding that support from the baby's father is needed as a strong decision exclusively breastfeeding mothers. Pediatricians and midwives have an important role to support in providing exclusive breastfeeding from mothers and infants. Mothers who work full time find it very difficult to care for their babies exclusively. The workplace can be a barrier for mothers to care for and provide exclusive breastfeeding. Breastfeeding competency-based training is needed as a more optimal promotion of exclusive breastfeeding. Promotion of breastfeeding can increase the duration and exclusivity of breastfeeding. Knowledge promotes breastfeeding can increase the chances of successful breastfeeding and improve baby's health. An important role in the successful promotion of breastfeeding is the quality of knowledge and support for exclusive breastfeeding.
Decentralization of public healthcare services in the Province of Sumatera Utara, Indonesia
Authors: Trimurni Februati , Mansor Norma
Published: November 2020

The research examined the effectiveness of decentralization program on the healthcare sector at the provincial level in the context of political and administrative decentralization. It adopted qualitative approach and employed the technique of in-depth interview, observation on documentation. Informants consist of public servants, practitioners, community and relevant stakeholders. The implementation of decentralization does not work that ideal for some reason: the devolution and the decentralization programs are not conducted simultaneously, mutually support and complimentary; the lack of local apparatus capabilities to understand and carry out the principles and the practices of the programs in the field; the limitation of financial sources and support to conduct the programs.
Analysis and potential use of Google Trends as a monitoring tool for risk communication during COVID-19 pandemic
Authors: Mahfuza Nindya , Syakurah Rizma Adlia , Citra Resiana
Published: November 2020

COVID-19 Pandemic has become a major problem in various infected countries, including Indonesia. The proper risk communication strategy during this outbreak was important to reduce the impact. Therefore, this research was intended to assess the potential use of Google Trends as a tool to monitor risk communication during COVID-19 pandemic in Indonesia. Search patterns were analyzed using the terminology used to identify COVID-19 in Indonesia, followed by information-finding keywords 'gejala (symptoms)', 'mencegah (preventing)', and 'obat (drug)' keywords compared to the number of newly confirmed COVID-19 cases in Indonesia using time-lagged correlation analysis from December 31th, 2019 to April 20th, 2020. Peaks within respective timelines were qualitatively described according to current COVID-19 related events. ”Corona” was the terminology mostly used in Indonesia to identify COVID-19. There were five spikes observed from “corona” keyword timeline, which each spike was dependent on the media coverage and regulation by the Government. Validation using time-lagged correlation yields significant results between corona, corona symptoms, preventing corona and corona drugs compared to newly confirmed COVID-19 cases in Indonesia. Google Trends can potentially be used to maximize the improvement of risk communication and as a tool to monitor public restlessness during the COVID-19 pandemic in Indonesia by Government.
Analysis of public search interest towards immune system improvement during the COVID-19 pandemic using Google Trends
Authors: Amelia Linda , Syakurah Rizma Adlia
Published: November 2020

In combating COVID-19, maintaining the immune system is important. Providing this information to the general population will increase public awareness towards improving their immune system. The use of Google Trends for exploring web behavior related to a topic or search term also considered as a tool for monitoring public awareness to help risk communication during the COVID-19 pandemic. Therefore, this study was conducted to assess the use of Google Trends to monitor public awareness to immune system improvement during the COVID-19 pandemic in Indonesia. This quantitative and qualitative research used time-series data from 31 December 2019 to 2 May 2020. The time-lag correlation analysis was performed to compare between relative search volume (RSV) of “Vitamin C”, “Vaksin” (Vaccine), “Berjemur” (Sunbathing) from Google Trends (GT), and the number of reported COVID-19 new cases. Validation using time-lag correlation shows the significant correlation between RSV keywords related to public awareness towards immune system improvement and the number of COVID-19 cases in Indonesia in 1-3 days before an increase in the number of cases occurs. Google Trends has the potential to become an early warning system and a tool for monitoring risk communication towards immune system improvement during the COVID-19 pandemic by Indonesia Government.
Prevalence of malnutrition among under-five children in Al-Nohoud province Western Kordufan, Sudan
Authors: Elnadif Elmanssury A.
Published: November 2020

Malnutrition remains one of the most common causes of childhood morbidity and mortality worldwide. The objective of this research was to determine the prevalence of malnutrition and related factors among Al-Nohoud children between 6-59 months of age. For the choice of parts, blocks and households, a three-stage sample design was used. Data collection was focused on anthropometric tests and structured questionnaires. The prevailing low weight, stunting and wasting of 16.7%, 13.5% and 17.6%, respectively, was shown. Two thirds (67%) %) of the affected children were 24 months. Female children were further underweight than male children. Home-wives achieved lower education levels and were higher in the mothers of malnourished children than those with healthy children. This study found that age of mothers, mother and family income have substantial malnutrition linked to children under the age of five (p= 000, X2= 57.40) (p= .004, X2= 41.00) (p= .00, X2= 32.74). The study found that under-five children were particularly malnutrition. Age ranges were significantly linked to wasting, stunting and underweight. Sex, mother's age, mother's level of education and family income differ greatly from malnutrition for children under the age of five.
Deriving the system equations of unbalanced two-phase induction motor
Authors: Shousha Hany Ibrahim , Kotb Abdelsamie B.
Published: November 2020

As there is no system driven especially for the two-phase induction motor fed from unbalanced two-phase supply yet, so we start for derivation the system equations for the said motor to be generally used even for the balanced or unbalanced two-phase supply. In this paper, we will derive a system equation starting from the sequence equivalent circuit for the forward and backwards equivalent circuits, then we will re-arrange the equations with some mathematical assumptions which will lead us to the new system equations. first for the voltage equations then for the current equations and finally for both power and torque equations. Moreover, we will put an example which will cover all cases with specific values and relations charts.
Implementation of PWM AC chopper controller for capacitor run induction motor drive via bacterial foraging optimization algorithm
Authors: Sivasubramanian Gobi Mohan , Narayanamurthy Murali
Published: November 2020

This paper focuses on design of closed-loop control for pulse width modulated AC chopper controlled capacitor run induction motor drive engaging enriched optimization algorithm based on foraging of bacteria. Capacitor run induction motor is a non-linear device and its parameter varies under different functional point of the system. A linearized increment model for PWM AC chopper is illustrated for a particular functional point of the drive. The conventional method does not provide acceptable performance under different load conditions. Bacteria foraging optimization technique categorizes accurate control parameters for the superlative dynamic response under unit step load variations. Field Programmable Gate Array is implemented practically for a particular functional point of the drive to exhibit accurate performance. Experimental and simulated results are obtained to authenticate the effectiveness of the optimized controller.

 
Substrate integrated circuits for high frequency of opto electronics
Authors: Punati Mounika , Yuvaraj R.
Published: November 2020

Another age of high-recurrence coordinated circuits is displayed, which is called substrate incorporated circuits (SICS). Current cutting edge of circuit plan and implementation stages dependent on this new idea are assessed and dis-cussed in delail. Various potential outcomes and various favorable circumstances of the SICS are appeared for microwave, millimeter-wave and opto hardware applications. Down to earth models are delineated with hypothetical and trial results for substrate coordinated waveguide (SIW), substrate incorporated chunk waveguide (SISW) and substrate incorporated non-transmitting dielectric (SI") direct circuits. Future innovative work patterns are likewise dis-cussed regarding ease imaginative plan of millimeter-wave and optoelectronic coordinated circuits.
Cardiac Pressure Overload Decreases ETV1 Expression in the Left Atrium, Contributing to Atrial Electrical and Structural Remodeling
Authors: Yamaguchi Naoko , Xiao Junhua , Narke Deven , Shaheen Devin , Lin Xianming , Offerman Erik , Khodadadi-Jamayran Alireza , Shekhar Akshay , Choy Alex , Wass Sojin Y. , Van Wagoner David R. , Chung Mina K. , Park David S.
Published: November 2020

Background:

Elevated intracardiac pressure attributable to heart failure induces electrical and structural remodeling in the left atrium (LA) that begets atrial myopathy and arrhythmias. The underlying molecular pathways that drive atrial remodeling during cardiac pressure overload are poorly defined. The purpose of this study is to characterize the response of the ETV1 (ETS translocation variant 1) signaling axis in the LA during cardiac pressure overload in humans and mouse models and explore the role of ETV1 in atrial electrical and structural remodeling.

Methods:

We performed gene expression profiling in 265 left atrial samples from patients who underwent cardiac surgery. Comparative gene expression profiling was performed between 2 murine models of cardiac pressure overload, transverse aortic constriction banding and angiotensin II infusion, and a genetic model of
Etv1
cardiomyocyte-selective knockout (
Etv1

f/f

Mlc2a

Cre
/+

).

Results:

Using the Cleveland Clinic biobank of human LA specimens, we found that
ETV1
expression is decreased in patients with reduced ejection fraction. Consistent with its role as an important mediator of the NRG1 (Neuregulin 1) signaling pathway and activator of rapid conduction gene programming, we identified a direct correlation between
ETV1
expression level and
NRG1
,
ERBB4
,
SCN5A
, and
GJA5
levels in human LA samples. In a similar fashion to patients with heart failure, we showed that left atrial ETV1 expression is downregulated at the RNA and protein levels in murine pressure overload models. Comparative analysis of LA RNA sequencing datasets from transverse aortic constriction and angiotensin II–treated mice showed a high Pearson correlation, reflecting a highly ordered process by which the LA undergoes electrical and structural remodeling. Cardiac pressure overload produced a consistent downregulation of
ErbB4
,
Etv1
,
Scn5a
, and
Gja5
and upregulation of profibrotic gene programming, which includes
Tgfbr1/2, Igf1
, and numerous collagen genes.
Etv1

f/f

Mlc2a

Cre
/+

mice displayed atrial conduction disease and arrhythmias. Correspondingly, the LA from
Etv1

f/f

Mlc2a

Cre
/+

mice showed downregulation of rapid conduction genes and upregulation of profibrotic gene programming, whereas analysis of a gain-of-function ETV1 RNA sequencing dataset from neonatal rat ventricular myocytes transduced with
Etv1
showed reciprocal changes.

Conclusions:

ETV1 is downregulated in the LA during cardiac pressure overload, contributing to both electrical and structural remodeling.