bluuebunny/crossref_metadata_2025 huggingface dataset:
Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day
Authors: Slomnicki Lukasz P. , Wei George , Burke Darlene A. , Hodges Emily R. , Myers Scott A. , Yarberry Christine D. , Morehouse Johnny R. , Whittemore Scott R. , Saraswat Ohri Sujata , Hetman Michal
Published: November 2021

The circadian gene expression rhythmicity drives diurnal oscillations of physiological processes that may determine the injury response. While outcomes of various acute injuries are affected by the time of day at which the original insult occurred, such influences on recovery after spinal cord injury (SCI) are unknown. We report that mice receiving moderate, T9 contusive SCI at ZT0 (zeitgeber time 0, time of lights on) and ZT12 (time of lights off) showed similar hindlimb function recovery in the Basso mouse scale (BMS) over a 6 week post-injury period. In an independent study, no significant differences in BMS were observed after SCI at ZT18 vs. ZT6. However, the ladder walking test revealed modestly improved performance for ZT18 vs. ZT6 mice at week 6 after injury. Consistent with those minor effects on functional recovery, terminal histological analysis revealed no significant differences in white matter sparing at the injury epicenter. Likewise, blood-spinal cord barrier disruption and neuroinflammation appeared similar when analyzed at 1 week post injury at ZT6 or ZT18. Therefore, locomotor recovery after thoracic contusive SCI is not substantively modulated by the time of day at which the neurotrauma occurred.
Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors
Authors: Pöll Gisela , Pilsl Michael , Griesenbeck Joachim , Tschochner Herbert , Milkereit Philipp
Published: November 2021

In yeast and human cells many of the ribosomal proteins (r-proteins) are required for the stabilisation and productive processing of rRNA precursors. Functional coupling of r-protein assembly with the stabilisation and maturation of subunit precursors potentially promotes the production of ribosomes with defined composition. To further decipher mechanisms of such an intrinsic quality control pathway we analysed here the contribution of three yeast large ribosomal subunit r-proteins rpL2 (uL2), rpL25 (uL23) and rpL34 (eL34) for intermediate nuclear subunit folding steps. Structure models obtained from single particle cryo-electron microscopy analyses provided evidence for specific and hierarchic effects on the stable positioning and remodelling of large ribosomal subunit domains. Based on these structural and previous biochemical data we discuss possible mechanisms of r-protein dependent hierarchic domain arrangement and the resulting impact on the stability of misassembled subunits.
Correlates of survival after autoantibody reduction therapy for acute IPF exacerbations
Authors: Kulkarni Tejaswini , Valentine Vincent G. , Fei Fei , Tran-Nguyen Thi K. , Quesada-Arias Luisa D. , Mkorombindo Takudzwa , Pham Huy P. , Simmons Sierra C. , Dsouza Kevin G. , Luckhardt Tracy , Duncan Steven R.
Published: November 2021

Background

No medical treatment has proven efficacy for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), and this syndrome has a very high mortality. Based on data indicating humoral autoimmune processes are involved in IPF pathogenesis, we treated AE-IPF patients with an autoantibody reduction regimen of therapeutic plasma exchange, rituximab, and intravenous immunoglobulin. This study aimed to identify clinical and autoantibody determinants associated with survival after autoantibody reduction in AE-IPF.

Methods

Twenty-four(24) AE-IPF patients received the autoantibody reduction regimen. Plasma anti-epithelial autoantibody titers were determined by HEp-2 indirect immunofluorescence assays in 22 patients.

Results

Mean age of the patients was 70 + 7 years old, and 70% were male. Beneficial clinical responses that occurred early during therapy were a favorable prognostic indicator: supplemental O2 flows needed to maintain resting SaO2>92% significantly decreased and/or walk distances increased among all 10 patients who survived for at least one year. Plasma anti-HEp-2 autoantibody titers were ~-three-fold greater in survivors compared to non-survivors (p<0.02). Anti-HEp-2 titers >1:160 were present in 75% of the evaluable one-year survivors, compared to 29% of non-survivors, and 10 of 12 patients (83%) with anti-HEP-2 titers <1:160 died during the observation period (Hazard Ratio = 3.3, 95% Confidence Interval = 1.02–10.6, p = 0.047).

Conclusions

Autoantibody reduction therapy is associated with rapid reduction of supplemental oxygen requirements and/or improved ability to ambulate in many AE-IPF patients. Facile anti-epithelial autoantibody assays may help identify those most likely to benefit from these treatments.
Nutritional status and body composition in cognitively impaired older persons living alone: The Takashimadaira study
Authors: Iwasaki Masanori , Motokawa Keiko , Watanabe Yutaka , Hayakawa Misato , Mikami Yurie , Shirobe Maki , Inagaki Hiroki , Edahiro Ayako , Ohara Yuki , Hirano Hirohiko , Shinkai Shoji , Awata Shuichi
Published: November 2021

Objectives

To investigate nutritional status and body composition in cognitively impaired older persons living alone.

Methods

This cross-sectional study included 1051 older adults (633 women and 418 men, mean age: 77.1 years) from the Takashimadaira study. The study participants were categorized according to whether they lived alone, which was confirmed via questionnaire, and had cognitive impairment, which was defined as having a Mini Mental State Examination-Japanese score ≤23. Nutritional status was evaluated using the serum albumin level. The fat-free mass index (FFMI) was calculated based on anthropometric and body composition measurements. A logistic regression model with the outcome of a low serum albumin level (serum albumin <4 g/dL) and low FFMI (<16 kg/m2 in men and <14 kg/m2 in women) were used to analyze the data.

Results

The percentages of participants in the living alone (-)/cognitive impairment (-) group, the living alone (+)/cognitive impairment (-) group, the living alone (-)/cognitive impairment (+) group, and the living alone (+)/cognitive impairment (+) group were 54.8%, 37.3%, 5.6%, and 2.3%, respectively. Compared to the living alone (-)/cognitive impairment (-) group, the living alone (+)/cognitive impairment (+) group was more likely to have a low serum albumin level (adjusted odds ratio = 3.10, 95% confidence interval = 1.31 to 7.33) and low FFMI (adjusted odds ratio = 2.79, 95% confidence interval = 1.10 to 7.06) after adjusting for potential confounders.

Conclusion

Cognitively impaired older adults living alone had poorer nutrition than cognitively normal and cohabitating persons in this study. Our results highlight the importance of paying extra attention to nutritional status for this group of community-dwelling older adults.
RESULTS FROM A PHASE II STUDY TO ASSESS THE CLINICAL AND IMMUNOLOGICAL ACTIVITY OF AFFITOPE® AD02 IN PATIENTS WITH EARLY ALZHEIMER’S DISEASE
Authors: Schneeberger A. , Hendrix S. , Mandler M. , Ellison N. , Bürger V. , Brunner M. , Frölich L. , Mimica N. , Hort J. , Rainer M. , Imarhiagbe D. , Kurz A. , Peters O. , Gertz H.-J. , Tierney L. , Mattner F. , Schmidt W. , Dubois B.
Published: November 2021

OBJECTIVES: The primary objective of this clinical trial was to assess the clinical activity of various doses and formulations of AFFITOPE® AD02 following its repeated s.c. administration to patients with early Alzheimer´s disease (AD), based on the evaluation of cognitive and functional domains. DESIGN: It was designed as a randomized, placebo-controlled, parallel group, double blind, multicenter phase II trial with 10 regular outpatient visits and 6 telephone interviews. SETTING: The trial was performed at 32 sites in six countries. PARTICIPANTS: A total of 332 patients were enrolled and 265 patients completed the trial in 3 treatment groups with AD02 and 2 control groups with aluminum oxihydroxide, here named IMM-AD04. Patients were randomly assigned to 5 groups: two doses of IMM-AD04, 25µg AD02 (in two different formulations) and 75µg AD02. INTERVENTION: At months 0, 1, 2, 3, 9 and 15, each patient received a single s.c. injection of the corresponding preparations of AFFITOPE® AD02 or the control, IMM-AD04. MEASUREMENTS: Co-primary efficacy outcomes included a measure of cognition (adapted AD Assessment Scale cognitive [aADAS cog]), and a measure of function (adapted AD Cooperative Trial Activities of Daily Living [aADCS-ADL]). A primary composite score was the sum of these two scores. RESULTS: Treatments were generally well tolerated and adverse events (AEs) were seen at similar rates across all treatment groups, with the exception that more injection site reactions were seen in the groups with a higher level of adjuvant. None of the AD02 groups showed a benefit over the IMM-AD04 controls for primary or exploratory efficacy outcomes. The control groups differed on aADCS-ADL and therefore couldn’t be pooled (p=0.039). Unexpectedly, the 2mg IMM-AD04 showed statistically significant effects over the other groups on several clinical outcomes including: aADAS-cog, aADL, Composite, ADAS-cog, CDR-sb, and QOL-AD Caregiver as well as two biomarker outcomes: right and total hippocampal volume (all p<0.05). 48% of patients in the IMM-AD04 2mg group had no decline in the composite outcome over 18 months compared to 17%-31% in the other groups, which is consistent with historical placebo groups. CONCLUSION: No significant treatment effects were seen for the investigational compound AD02. However, the IMM-AD04 2mg group showed statistically significant effects over all other groups on several clinical outcomes as well as a slowing of decline on right hippocampal volume. The data support further development of IMM-AD04 as a disease modifying agent in line with EMA/FDA definitions.
A teoria de justiça de Dworkin e sua aplicação no domínio dos transportes
Authors: De Lima Jessica Helena , Maia Maria Leonor Alves
Published: November 2021

As questões relativas à justiça e equidade nos transportes vêm crescendo em importância na literatura dos transportes nos últimos anos. No entanto, por tratar-se de um conceito normativo, a definição de equidade nos transportes perpassa pelo compreendimento de uma teoria de justiça e do significado de equidade no contexto desta teoria. Além disso, é preciso avaliar se é possível aplicar a lupa dos transportes a uma determinada teoria sem que a sua essencialidade lógica seja perdida. Este artigo revisa quatro teorias de justiça recorrentes na literatura e avalia criticamente as suas disposições considerando a perspectiva dos transportes e propõe B a utilização da teoria de Dworkin para o embasamento das análises. A escolha dessa teoria se deu por dois motivos principais: a) a linha de pensamento de Dworkin permite a extensão de sua teoria para analisar problemas específicos, sem a necessidade de desenvolver uma teoria mais abrangente de justiça social; e b) a noção de equidade de distribuição é diretamente ligada ao custo de prover a distribuição desejada.
PROFESOR SILVIO PANCIERA (WENECJA, 21.03.1933 – RZYM, 16.08.2016)
Authors: Mrozewicz Leszek
Published: November 2021

Profesor Silvio Panciera (Wenecja, 21.03.1933 - Rzym, 16.08.2016)
VERBA PERFECTA IN TYPOLOGISCHER HINSICHT. PIOTR MIKHAYLOVICH ARKADJEV, AREAL’NAJA TIPOLOGIJA PREFIKSAL’NOGO PERFEKTIVA (NA MATERIALE JAZYKOV JEVROPY I KAVKAZA), STUDIA PHILOLOGIGA, MOSKVA 2015, S. 352.
Authors: Chernyukh Bohdan
Published: November 2021

Verba perfecta in typologischer hinsicht, rec. książki: Piotr Mikhaylovich Arkadjev, Areal’naja tipologija prefiksal’nogo perfektiva (na materiale jazykov Jevropy i Kavkaza)
ZNACZENIE ALMANACHU 1C Z KODEKSU DREZDEŃSKIEGO DLA ROZWOJU EPIGRAFIKI MAJAŃSKIEJ
Authors: Jagodziński Kajetan
Published: November 2021

This papers seeks to demonstrate the tremendous importance of the usually omitted first page of the Dresden Codex for the ongoing process of deciphering Mayan script. As an example, one could quote the recently identified Mayan term denoting a loincloth (Span. braguero, taparrabo) in the almanac 1c, which may be found on the page in question. Furthermore, the author critically discusses all possible forms in which the word can have been written, as it still defies being deciphered completely.
Łaciński viridis, włoski verde, polski zielony – językowo-kulturowe studium barwy zielonej
Authors: Skuza Sylwia
Published: November 2021

The aim of the study is to discuss the place of the colour green with its shades in Italian and Polish since antiquity (Latin) until the present times. Furthermore, the author shows the differences and similarities between these languages in their diachronic perception of the colour green. The colour is be also analysed in general in the light of European culture, where green has its established position.
Między archiwum a bazą danych – o doświadczeniu sztuki nowych mediów
Authors: Szykowna Sylwia
Published: November 2021

The essential objective of this paper is to examine the category of archive from the perspective of new media, which transform the model of linear his-torical discourse into a new one, whereby it assumes the form of a database, enabling novel modes of indexing reality
A Short Argument against Truthmaker Maximalism
Authors: Bondar Oleh
Published: November 2021

Mark Jago has introduced a short Fitch-style argument for truthmaker maximalism – the thesis that every truth has a truthmaker. In response to Jago, Trueman argues that the Fitch-style reasoning allows us to prove the opposite – no truth has a truthmaker. In the article, we consider the debates between Jago’s truthmaker maximalism and Trueman’s truthmaker nihilism. Also, we introduce a short Grim-style argument against Jago’s truthmaker maximalism.
Increased Connectivity among Sensory and Motor Regions during Visual and Audiovisual Speech Perception
Authors: Peelle Jonathan E. , Spehar Brent , Jones Michael S. , McConkey Sarah , Myerson Joel , Hale Sandra , Sommers Mitchell S. , Tye-Murray Nancy
Published: November 2021

In everyday conversation, we usually process the talker's face as well as the sound of the talker's voice. Access to visual speech information is particularly useful when the auditory signal is degraded. Here, we used fMRI to monitor brain activity while adult humans (n= 60) were presented with visual-only, auditory-only, and audiovisual words. The audiovisual words were presented in quiet and in several signal-to-noise ratios. As expected, audiovisual speech perception recruited both auditory and visual cortex, with some evidence for increased recruitment of premotor cortex in some conditions (including in substantial background noise). We then investigated neural connectivity using psychophysiological interaction analysis with seed regions in both primary auditory cortex and primary visual cortex. Connectivity between auditory and visual cortices was stronger in audiovisual conditions than in unimodal conditions, including a wide network of regions in posterior temporal cortex and prefrontal cortex. In addition to whole-brain analyses, we also conducted a region-of-interest analysis on the left posterior superior temporal sulcus (pSTS), implicated in many previous studies of audiovisual speech perception. We found evidence for both activity and effective connectivity in pSTS for visual-only and audiovisual speech, although these were not significant in whole-brain analyses. Together, our results suggest a prominent role for cross-region synchronization in understanding both visual-only and audiovisual speech that complements activity in integrative brain regions like pSTS.

SIGNIFICANCE STATEMENTIn everyday conversation, we usually process the talker's face as well as the sound of the talker's voice. Access to visual speech information is particularly useful when the auditory signal is hard to understand (e.g., background noise). Prior work has suggested that specialized regions of the brain may play a critical role in integrating information from visual and auditory speech. Here, we show a complementary mechanism relying on synchronized brain activity among sensory and motor regions may also play a critical role. These findings encourage reconceptualizing audiovisual integration in the context of coordinated network activity.
Facultad de Medicina Veterinaria y de Zootecnia: cien años aportando a la salud y a la producción animal
Authors: Botero Espinosa Lucía
Published: November 2021

Revista de la Facultad de Medicina Veterinaria y de Zootecnia Universidad Nacional de Colombia. ISSN 0120-2952
Prevalencia y efecto de la infección intramamaria debida a especies de estafilococos coagulasa negativo (ECN) en el conteo de células somáticas en leche de vacas Holstein en Boyacá, Colombia.
Authors: Andrade-Becerra R. J , Tarazona-Manrique L. E. , Vargas-Abella J. C.
Published: November 2021

La mastitis es una de las enfermedades más importantes en los rebaños lecheros especializados alrededor de todo el mundo debido a los efectos sobre la producción y la salud animal. Los tipos ocasionados por estafilococos coagualasa negativo (ECN) tienen una importancia especial en una producción en la que los principales patógenos están controlados. El objetivo del presente trabajo es determinar la prevalencia del ECN en un hato lechero en Boyacá y cuantificar los efectos de cada especie de ECN en el conteo de células somáticas (CCS). Se seleccionaron 40 vacas y se tomaron muestras durante 6 meses, se realizó california mastitis test (CMT) y se tomaron muestras de los resultados desde 1 hasta donde hubo trazas. También se realizó la prueba bacteriológica de rutina para la identificación del ECN y el aislamiento del ECN se realizó mediante la identificación del gen rpoB y del tipo de cepa, usando el procedimiento de electroforesis en gel de pulso. De 960 muestras, 619 fueron positivas para el crecimiento del ECN. Las especies más prevalentes fueron Staphylococcus epidermidis, S. chromogenes, S. sciuri, S. simulans, S. haemolyticus y S. capitis. Los resultados encontrados aquí son similares a resultados en diferentes partes del mundo, lo que confirma que son patógenos que deben ser evaluados constantemente porque pueden pasar desapercibidos en los controles de rutina, especialmente en aquellas fincas donde los patógenos mayores no son un problema grave. Los resultados determinados en este estudio demuestran que el SNC genera un ligero aumento de células somáticas.
MANAJEMEN RISIKO UNIT USAHA SYARIAH BANK PEMBANGUNAN DAERAH JAMBI PADA PEMBIAYAAN MURABAHAH MODAL KERJA
Authors: Syahrizal Ahmad
Published: November 2021

Penelitian ini dilakukan untuk mengetahui bagaimana penerapan manajemen risiko pada pembiayaan murabahah modal kerja Unit Usaha Syariah Bank Pembangunan Daerah (BPD) Jambi. Pembiayaan murabahah modal kerja memiliki risiko yang cukup besar dibandingkan pembiayaaan lainnya sehingga Unit Usaha Syariah BPD Jambi dituntut untuk menyusun, menetapkan dan menerapkan manajemen risiko yang baik. Metode yang digunakan dalam proses penelitian adalah studi empiris dengan metode kualitatif  deskriptif berdasarkan data dan informasi yang didapatkan dilapangan. Berdasarkan hasil penelitian didapati bahwa dalam pembiayaan murabahah modal kerja Unit Usaha Syariah BPD Jambi telah menerapkan manajemen risiko yang cukup baik dengan adanya proses identifikasi risiko-risiko yang yang bisa saja terjadi dalam pembiayaan, adanya pengukuran risiko-risiko yang kemungkinan terjadi dengan mengamati dan membaca data serta riwayat pembiayaan calon nasabah, adanya pengelolaan dan pengendalian risiko dengan sistem tagihan, penerbitan surat peringatan serta mediasi penyelesaian permasalahan pembiayaan nasabah. Manajemen risiko yang diterapkan tergolong efektif dengan adanya peningkatan capaian pada pembiayaan murabah modal kerja tersebut.
KINERJA KEUANGAN PERBANKAN SYARIAH PADA MASA COVID-19 DAN STRATEGI PENINGKATANNYA
Authors: Hidayat Ridwan , Umam Ripqi , Tripalupi Ramadhani Irma
Published: November 2021

Tulisan ini bertujuan untuk memaparkan kinerja keuangan perbankan syariah di Indonesia pada masa pandemi Covid-19 dan strategi peningkatanya, dimana pandemi tersebut sangat berdampak buruk terhadap perekonomian. Penelitian ini merupakan penelitian kualitatif, di mana metode yang digunakan adalah deksriptif analisis. Data dalam penelitian ini merupakan data sekunder yang teknik pengumpulan datanya menggunakan dokumentasi. Analisis data menggunakan triangulasi data yaitu, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian yang diperoleh adalah; (1) kinerja keuangan perbankan syariah pada masa pandemi Covid-19 masih baik dan positif, hanya perlu ditingkatkan jika dibandingkan dengan bank konvensional; (2) strategi peningkatan kinerja keuangan bank syariah adalah restrukturisasi pembiayaan, penambahan jangka waktu pembiayaan, penyempurnaan regulasi, dan digitalisasi layanan bank; dan (3) dalam konteks ekonomi, lembaga keuangan berperan dalam memulihkan ekonomi nasional dengan memobilisasi simpanan, menyumbangkan modal risiko dalam krisis, dan mengembangkan Fintech Syariah.
Whiteness and the Rainbow: White LGBTQ+ College Students’ Racial Identity Development
Authors: Noble Chelsea , Renn Kristen
Published: November 2021

LGBTQ+ communities and spaces on college campuses are often known as white-centered spaces, implicitly or explicitly excluding students of color. While White LGBTQ+ students may experience marginalization and exclusion on the basis of their sexual orientations and/or gender identities, they may unwittingly perpetuate oppression on the basis of race. Utilizing Helms’ (1990) white racial identity development model, this study explored how White LGBTQ+ college students understand their racial identity and white privilege. The sample of 12 White LGBTQ+ college students was drawn from a larger four-year longitudinal qualitative study of LGBTQ+ college student success. In early interviews, students either did not discuss their white racial identity or did not view their white racial identity as a salient aspect of their identity. However, students increasingly spoke about their white identities, race, and racism in later interviews. Interpersonal experiences, academic engagement, and national events provided access points for White LGBTQ+ students to talk about race and their white identities. Implications for research and practice with White LGBTQ+ college students and in LGBTQ+ campus spaces are discussed.
Cash Management in Russian Metallurgical and Oil and Gas Companies
Authors: Olga  , Panasenko Kristina
Published: November 2021

The problem of money management has remained relevant over the past years. The aim of the study is to assess the impact of debt and cash flow on the amount of cash on companies with and without financial constraints. The main hypothesis of the study is that the impact of debt and cash flow on the level of cash depends on financial constraints which were taken as two proxy variables – dividend payment and bond rating. To substantiate the hypothesis put forward, a regression model of the influence of debt and cash flow on the level of cash is built in the work.

For the analysis, large Russian companies in the metallurgical and oil and gas industries were sorted in accordance with financial constraints. Based on the results of the constructed regression model, the following conclusions can be drawn. Borrowed funds of companies negatively affect the amount of cash on the balance sheet, regardless of the presence andtype of financial constraints. Cash flow is not statistically significant for companies without financial constraints.

This study has some limitations. The research results can be useful for corporate CFOs in order to optimize cash balances.
Floristics of flowering plants from the understory of Atlantic remnants in central and southern Bahia, Brazil
Authors: Borges Rodrigo L. , Ferreira Patrícia A. , Viana Blandina F. , Guedes Maria L.S. , Roque Nádia
Published: November 2021

The Atlantic Rainforest has high species diversity and endemism and is one of the most threatened ecosystems in the world. However, the rainforest understory stratum is regarded as the least studied and understood with regards to biodiversity. The aim of our study was to develop an up-to-date checklist of flowering plants collected in 10 Atlantic Rainforest remnants in Southern Bahia, Brazil. The floristic inventory recorded 49 families, 103 genera, and 170 species. The richest families were Rubiaceae (34 spp.), Melastomataceae (16), Bromeliaceae, Poaceae (8 spp.), Cyperaceae, Erythroxylaceae, Marantaceae, Myrtaceae, and Piperaceae (7). We record 10 new state records for Bahia and two new taxonomic novelties (Bertolonia sp. nov. and Palicourea sp. nov.) were discovered. The species composition is very exclusive with 85% of species occurring in only one of the studied areas and 27% being endemic to this biome region.
New combinations in Nearctic endemic Euphrasia (Orobanchaceae)
Authors: Gussarova Galina
Published: November 2021

Evolution of locally unique species has been important in Nearctic Euphrasia. Fifty percent of Euphrasia species in the flora of North America are considered endemic. Revision of taxonomic status of infraspecific units of endemic species was carried out while preparing the treatment for the Flora of North America. Two new combinations and changes in rank are proposed here: Euphrasia oakesii Wettst. var. williamsii (B.L. Rob.) Gussarova, comb. & stat. nov. and Euphrasia farlowii (B.L. Rob.) Gussarova, comb. & stat. nov.
Adlumia fungosa (Fumariaceae), New to the Flora of LOUISIANA (U.S.A.)
Authors: Allen Charles M.
Published: November 2021

Allegheny Vine Adlumia fungosa  (Fumariaceae) is reported new to Louisiana, U.S.A.
[RETRACTED] Maximum Edge Nutrition Glucotrust v1
Authors: Bowen Jo
Published: November 2021

[RETRACTED]

Clear And Unbiased Facts About Glucotrust
Multi tissue processing for single cell sequencing of human immune cells v1
Authors: Rainbow Daniel , Howlett Sarah , Jarvis Lorna , Jones Joanne
Published: November 2021

This protocol has been developed for the simultaneous processing of multiple human tissues to extract immune cells for single cell RNA sequencing using the 10X platform, and ideal for atlasing projects. Included in this protocol are the steps needed to go from tissue to loading the 10X Chromium for single cell RNA sequencing and includes the hashtag and CiteSeq labelling of cells as well as the details needed to stimulate cells with PMA+I.
On sarcomach of the uterus
Authors: Weber F. K.
Published: November 2021

After Virchow had accurately established the concept of sarcomas in general, and in 1860 at the Berlin Gynaecological Society, the first undisputed case of uterine sarcomas was presented, confirmed by a thorough microscopic examination, a number of works on uterine sarcomas have appeared in the literature, some of which are purely caustic in nature and some provide a detailed description of the pathological and anatomical structure of tumours.
Incorrectness of menstruation, in particular intensified menstruation.
Authors: Dauchet H.
Published: November 2021

On 308 cases, absolutely correct menstruation in the first year of puberty was observed in 176 girls, in the rest there were observed: absence of menstruation 56 times, sick menstruation 34 times and increased menstruation 42 times.
Pathological and anatomical changes in the liver and kidneys with eclampsia
Authors: Guyeisse B.
Published: November 2021

Since 1890, the authors investigated 19 cases of liver damage in eclamptics. From this number, the authors believe, however, it is necessary to exclude five cases in which death caused a summer, so that the rapid decomposition of corpses prevented the use of autopsy material in proper conditions.
Meeting of obstetric and gynecological societies Protocol No. 94
Authors: Rein G. E.
Published: November 2021

It was chaired by prof. G. E. Rein
On the issue of breast nipple disease in the postnatal time, about caring for them and about their treatment
Authors: Libov B. A.
Published: November 2021

(Doctor. 1898, No. 11, p. 412). Nipple soreness in the postnatal time is either in the form of abrasions and cracks (first stage), or in the form of ulcers (postpartum stage).
On the issue of late miscarriageѣ
Authors: Ivanov N. K.
Published: November 2021

(Doctor. 1898, No. 15, p. 425).In contrast to some views, the author thinks that a belated miscarriage is not met easily.
Therapy of candidosis vulvovaginitis at pregnancy
Authors: Simchera I. A. , Kira E. F. , Dobrynin V. M.
Published: November 2021

Clinical effectiveness gyno-pevaryl (GP) is investigated at treatment acute (30 women) and chronic (38 patients) candidosis vulvovaginitis in the period of pregnancy. In an end of course of treatment GP clinical and laboratory the confirmed recovery is marked in the first group at 80.0 % patients, in the second and the third - at 76.3 % patients. Gynopevaryl is an effective preparation for local treatment acute and chronic candidosis vulvovaginitis.
A place of a preparation «Divina» in treatment perimenopausal of disorders
Authors: Repinа M. A.
Published: November 2021

In an article are considered problems of effective application of a preparation Divina for hormone replacement therapy (HRT) at patients in perimenopausal period.
Application of perftoruglerods for treatment fetal intranatal hypoxia (experimental research)
Authors: Lebedzevich Lu. S.
Published: November 2021

Learning influence perftoruglerods of connections on current and outcome of pregnancy in experiment is spent. Efficiency is proved applications perftorans in a doze 10 mg/kg of a mass for treatment of chronic fetal intranatal hypoxia. Is shown favorable therapeutic effect on metrics peroxide lipide oxidetion, state born of fetus and mechanism of its implementation is justified.
Atrophic colpitis. Pathogenesis. Preventive treatment. Treatment.
Authors: Radzinskij V. E. , Ordijanc I. M.
Published: November 2021

Main links pathogenesis of atrophic colpitis were considered, were investigated dependence urogenital of infections and of trofic violations at the women in the menopausal period. The most expressed changes on the part of microbiological and cytological of metrics with the purpose of development of methods of preventive maintenance and treatment colpitis at the women of the menopausal period were appreciated. In the programme of treatment were included preparations for restoring microbiocenosis of an organism. It was shown, that, apart from hormone replacement therapy, the preventive maintenance atrophic colpitis is impossible without normalisation biocenosis of urogenital of a tract.
International cooperation and training of midwives
Authors: Dymchenko L. N.
Published: November 2021

One of the areas of international cooperation carried out by the St. Petersburg Obstetric College is joint activities with the British Association Hele Prom. This nongovernmental organization assists in the development of health care in the republics of the former Soviet Union. An important part of this work is to ensure maternal and child health.
Efficiency of preventive maintenance after confinement postpartum infectious diseases of the pregnant women with bacterial vaginosis (BV) and colpitis
Authors: Radzinskij V. E. , Ordijanc I. M. , Serebrjannik E. L.
Published: November 2021

Were examined 55 pregnant women with the purpose of development of optimum methods of preventive maintenance and treatment postpartum infectious diseases. Differential diagnostics between BV and colpitis was conducted, pathological attributes BV in the period of pregnancy in sorts and postpartum established. A microbial flora of the pregnant womens vagines with BV and colpitis with normal and with complicated current of pregnancy was investigated. The preventive maintenance and treatment of postpartum infectious mothers diseases, foetus, baby at pregnant women with BV and colpitis based on restoration microbiocenosis and local immunoresistence.
Oxidiring updating of protein and endogenic intoxication as parameters of weight EPH-gestosis
Authors: Kostuchek D. F. , Sokolova L. V.
Published: November 2021

Is investigated contents of substances low and average molecular of weight (SLAMW) in plasma of blood, in erythrocytes and urine, and process of oxidizing updating serum s proteins of blood at 11 unpregnant women, at 22 pregnant women with physiological current of pregnancy, at 9 pregnant of risks group on development EPH-gestosis and at 33 pregnant, suffering by EPH-gestosis. On the basis of received facts following conclusions were made. Processes of agrgation of proteins prevail at physiological current of pregnancy. Endogenic intoxication at healthy pregnant not observed. In connection with an increase of concentration the active forms of an oxygen in a body of pregnant from risks group, process of agrgation of protein considerably more intensive. We can observe among the pregnant of risks group the first compensatory phase of endogenic intoxication, which accompanied by increase SLAMW in erythrocytes. The oxidizing updating of protein amplifies in a greater degree at pregnant women suffering by EPH- gestosis. Is observed as agrgation of proteins molecules, as its destruction.
Influence of the adverse industrial factors to a state of fagocytic activity of neutrophils of peripheral blood in women of chemical manufacture
Authors: Bezhenar V. F. , Grebenjuk A. N. , Antushevich A. E.
Published: November 2021

In the article was considered a problem long-duration a combined effect of toxic ksenobiotics on the factors non-specific resistence of immunity of workwomen of chemical manufacture. It was shown a high forecasted value of investigated parameters of fagocitic activity of neutrophils of blood in valuation of the condition of immunity system, and correlation gears of interrelation of the factors a system non-specific peg. With a level and features of morbidity of the surveyed women.
Participation of the gynaecologist and the dermatovenereologist in a system of a hygienic education of under-ages
Authors: Lusan N. V. , Davidova S. V.
Published: November 2021

In the article on origin sight of the authors on the decision of a problem a hygenic education and social behaviour of under-ages is submitted.
Prostitution and population
Authors: Zharkov Yu. N.
Published: November 2021

A publicist article examines some aspects of the problem of prostitution.
The results and prospectives of gynecological endovideosurgery development
Authors: Kira E. F. , Bezhenar V. F. , Berlev I. V.
Published: November 2021

Authors, on the basis literary given and by the results of researches present the detailed analysis of efficiency and expediency of endovideosurgical methods of diagnostics and treatment in GYN practice. There are considered indications, contra-indication, features of the methodical approaches with use of specified methods under urgent condition and in planned GYN. Prospective directions of development of the new technological approaches in modern operative GYN are also considered.
Danoval and omnadren effect on the patients with dysfunctional uterine bleedings during the premenopause
Authors: Gumenyuk E. G. , Samorodinova L. A.
Published: November 2021

Initial level of gonadothropic, steroid hormones in the blood, receptors of estradiol and progesteron of the endometrium in the patients with dysfunctional uterine bleedings during the premenopause, and their dunamics during and after hormone therapy were studied.

Danoval and oxy prog esterone-capronat in combination with omnadren had different effect on the parameters of the hormonal homeostasis and receptor apparatus of the endometrium. Antigonadоthropic effect of danoval results in FSG level reduction, estradiol and progesterone decrease in the blood and that of steroid receptors in the endometrium, that did not take place with other therapies. The effectiveness of the treatment with danoval was 88,24%, and it was 62,50% when oxy prog esterone-capronat with omnadren therapy was used.

It is concluded that danoval prescription to the patients with dysfunctional uterine bleedings during the menopause is more expedient for the wide spectrum of antigonadothropic effect.
The clinical experience of Gynipral application in pregnant and during labor
Authors: Repina M. A. , Kulagina N. V. , Kornilova Ya. A.
Published: November 2021

In modern obstetrics there is an urgent problem of treatment of threat of premature labor being one of the basic reasons for perinatal losses. In the article the prospects of Gynipral application in pregnant women, and also the results of practical application of a drug in clinic are considered. It is proved, that the application of beta-adrenomimetic Gynipral allows effectively and without development of complications on the part of the mother to carry out the treatment of premature labor threat, hypoxia a fetus, discoordination in labor, that provides the perinatal morbidity and mortality reduction.
Use of Divena and Divitren for treatment of the typical form of climacteric syndrome
Authors: Ryabtceva I. T. , Shapovalova K. A. , Kucheryavenko A. N.
Published: November 2021

In the work the clinic and lab researches of substitute hormonal therapy (SHT) to climacteric syndrome (CS) by the combined drugs Divina and Divitren, containing natural estrogens and gestagen are submitted. 24 patients received Divina and 16 - Divetren. Up to 6 months of treatment the control of a status of their health with application of hormonal, USG, cytolic and histologic methods was carried out. The efficiency of treatment has made 92,5%. The side-effect didnt require the cancellation of drug administration. The received results testify to validity SHT with Divina and Divetren in women with CS.
A Perfectly Matched Layer Technique Applied to Lattice Spring Model in Seismic Wavefield Forward Modeling for Poisson’s Solids
Authors: Tang Jinxuan , Zhou Hui , Jiang Chuntao , Xia Muming , Chen Hanming , Zheng Jinxin
Published: November 2021

As a complementary way to traditional wave-equation-based forward modeling methods, lattice spring model (LSM) is introduced into seismology for wavefield modeling owing to its remarkable stability, high-calculation accuracy, and flexibility in choosing simulation meshes, and so forth. The LSM simulates seismic-wave propagation from a micromechanics perspective, thus enjoying comprehensive characterization of elastic dynamics in complex media. Incorporating an absorbing boundary condition (ABC) is necessary for wavefield modeling to avoid the artificial reflections caused by truncated boundaries. To the best of our knowledge, the perfectly matched layer (PML) method has been a routine ABC in the wave-equation-based numerical modeling of wave physics. However, it has not been used in the nonwave-equation-based LSM simulations. In this work, we want to apply PML to LSM to attenuate the boundary reflections. We divide the whole simulation region into PML region and inner region, PML region surrounds the inner region. To incorporate PML to LSM, we establish elastic-wave equations corresponding to LSM. The simulation in the PML region is conducted using the established wave equations and the simulation in the inner region is conducted using LSM. Three simulation examples show that the PML scheme is effective and outperforms Gaussian ABC.
Fast and Robust Earthquake Source Spectra and Moment Magnitudes from Envelope Inversion
Authors: Eulenfeld Tom , Dahm Torsten , Heimann Sebastian , Wegler Ulrich
Published: November 2021

With the present study, we introduce a fast and robust method to calculate the source displacement spectra of small earthquakes on a local to regional scale. The work is based on the publicly available Qopen method of full envelope inversion, which is further tuned for the given purpose. Important source parameters—seismic moment, moment magnitude, corner frequency, and high-frequency fall off—are determined from the source spectra by fitting a simple earthquake source model. The method is demonstrated by means of a data set comprising the 2018 West Bohemia earthquake swarm. We report moment magnitudes, corner frequencies, and centroid moment tensors inverted from short-period body waves with the Grond package for all earthquakes with a local magnitude larger than 1.8. Moment magnitudes calculated by envelope inversion show a very good agreement to moment magnitudes resulting from the probabilisitc moment tensor inversion. Furthermore, source displacement spectra from envelope inversion show a good agreement with spectra obtained by multiple taper analysis of the direct onsets of body waves but are not affected by the large scatter of the second. The seismic moments obtained with the envelope inversion scale with corner frequencies according to M0∝fc−4.7. Earthquakes of the present data set result in a smaller stress drop for smaller magnitudes. Self-similarity of earthquake rupture is not observed. In addition, we report frequency-dependent site amplification at the used stations.
Photoresponse characteristics of the heterojunction bipolar transistor
Authors:   , De Barros Luiz Eugenio Monteiro , Herczfeld Peter R
Published: November 2021

As the need for high-volume communication systems grows, especially in densely populated areas, so follows the demand for faster, less costly and more reliable network infrastructure. Fiber optics provides plenty bandwidth space that applications such as Local Area Networks (LANs), video and data distribution (eg. CATV, SONET), optically fed wireless systems and remoting of radar, could benefit from it. However the opto-electronic interconnects are major bottlenecks in such systems. The HBT operating as a three-terminal photodetector is potentially the best solution for optoelectronic integrated receivers. It is compatible with post-detection electronics requiring no matching circuits which reduces parasitics and is capable of providing simultaneous gain and amplification at high frequencies. It also requires small bias voltages which leads to lower power consumption, a very attractive characteristic for monolithic circuits. This work presents a comprehensive theoretical and experimental analysis of the HBT under illumination. The study covers static, dynamic and noise properties of these devices when working as photodetectors. Other types of transistors are also investigated such as the MESFET and the HEMT. Experimental results for the three types of transistors are compared to currently used photodiodes (PIN and MSMs). A new HBT photodetector, the optical-HBT, is proposed, implemented and characterized. The new design enhances the sensitivity of conventional HBTs without degrading bandwidth. The optical-HBT is fully compatible with existing electronics, has low power consumption and provides large gain and bandwidth simultaneously.
X-linked agammaglobulinemia rare disease with a rarer presentation
Authors: Myathari Ramakrishna , Gupta Anand
Published: November 2021

X-linked agammaglobulinemia (XLA) is a rare disorder, characterized by absence of mature B cells leading to severe antibodies deficiency. This translates to recurrent sinopulmonary infections in affected children. The most common age group of presentation is 6 months to 2 years. Being an X-linked recessive disorder males are affected, females are carriers. Intravenous immunoglobulins and antibiotics remains the corner stone of treatment. Here in, we report a case of 11-year-old male having recurrent episodes of fever with one episode of hospitalization 3 years back. Child was treated at healthcare facility elsewhere for recurrent fever. He presented to our institute with signs and symptoms suggestive of meningitis, investigated, had culture proven Staphylococcus aureus meningitis with a low Absolute Lymphocyte Count (ALC). On further work up found to have low serum immunoglobulins (IgG, IgM, IgA) and Flowcytometry showing absence of B cells (CD19/CD20). Child was diagnosed to have XLA. This case highlights the importance of having strong clinical suspicion of XLA, despite not having recurrent sinopulmonary infections.
Correlation of ER PR receptors with other prognostic parameters of breast carcinoma
Authors: Pawar Vishrabdha Rahul , Anand Nekta , Zaidi Shahnaz
Published: November 2021

To study the MRM specimens for size, grade of the tumor, LVI and LN metastases and the ER/PR receptors of the tumor. To study the association of ER/PR status with the above mentioned prognostic parameters.

This three-year study includes 72 histopathologically confirmed cases of carcinoma breast. The tumor type, grade, LNM, LVE were reported on H & E. The ER-PR study was done of all 72 cases. The tumor size, grade, LNM, LVE were correlated with receptor status.

Out of 72 cases majority (53%) of cases were in 41-50 years of age group, and tumor size was between 2-4 cm in (54.16%) cases; majority were of grade II carcinoma (60%) of which 59% were ER-PR positive. Out of 46 cases with negative LNM and LVE, 30 cases (65%) were ER-PR positive.

In our observation there is no association between higher histological grade and ER-PR status. No obvious correlation with tumor size was noted. But increase in tumor size could also be a poor predictor of ER-PR status. LNM, LVE is poor predictor of ER-PR status.
D Dimer – Prognostic indicator for disease severity in patients hospitalised with COVID 19
Authors: Banga Vineet , Jain Stuti
Published: November 2021

Patients of Covid 19 infections present with different severity. Levels of D Dimer in these patients can be correlated with disease severity for management and prognosis.

To evaluate the usefulness of D-Dimer levels in blood to correlate with disease severity in COVID 19 patients.

Retrospective study was done in Department of Pathology of Secondary Care hospital that became designated covid hospital from May 2021 to June 2021 on 60 COVID 19 positive admitted patients. D dimer levels were analysed and correlated with clinical severity of disease.

Out of total 60 patients, 33 were in mild, 23 in moderate and 4 were in severe category. In mild cases D Dimer varies from 43 ng/ml to 183 ng/ml. In moderate cases D Dimer varies from 270 ng/ml to 991 ng/ml. In severe cases D Dimer varies from 1043 ng/ml to 2463 ng/ml. The study suggests cut off levels for D Dimer as up to 200 ng/ml for mild, 200-1000 ng/ml for moderate and more than 1000 ng/ml for severe category in COVID 19 patients.

D dimer helps in identifying severe disease and can be used as an essential biomarker in developing the management protocol for COVID 19 patients.
Verruciform xanthoma in groin – A case report
Authors: Gaikwad Nirmala
Published: November 2021

Verruciform xanthoma is a rare benign mucocutaneous lesion. Extra oral sites are also reported mainly on vulva, groin, penis and scrotum. Histopathologic diagnosis is diagnostic and confirmative. Histopathology shows subepithelial lipid laden foamy histiocytes associated with hyperkeratosis, parakeratosis, papillomatosis and elongation of rete ridges. Here we report a case of Verruciform xanthoma in groin.