bluuebunny/crossref_metadata_2025 huggingface dataset:
Inteligencia artificial, predicciones y funciones normativas
Authors: García Majado Patricia
Published: November 2024

El núcleo gordiano de los sistemas de inteligencia artificial, al menos desde el punto de vista jurídico, es que, en base a la cantidad de datos que manejan son capaces de ofrecer inferencias sobre lo que es más plausible que suceda en el futuro, es decir, arrojar predicciones. Este trabajo trata, precisamente, de explorar, desde un punto de vista de teoría general, el encaje que las predicciones pueden tener en el sistema normativo, entendido éste desde un punto de vista jurídico-positivo. Así, tras analizar si la predicción es o no la función que aquél tiene generalmente encomendada, pasa a estudiarse la implicación de aquélla en las dos funciones características del ordenamiento jurídico: la creación y la aplicación de normas.
Controversias sobre la calificación de enmiendas con repercusiones presupuestarias en el Senado
Authors: Nieto Jiménez José Carlos
Published: November 2024

En este artículo se analiza la compleja tramitación en el Senado de un proyecto de ley, protagonizada por las controversias surgidas en torno a la cuestión de la homogeneidad de las enmiendas y del veto presupuestario. Concretamente se presta atención al veto presupuestario del Gobierno a la tramitación de una propuesta de modificación presentada en fase de Pleno, a su rechazo por la Mesa del Senado y a la resolución de esta controversia por la presidenta del Senado, quien decidió la anulación de una votación plenaria celebrada dos días antes.
El nuevo constitucionalismo latinoamericano: un desafío al sistema interamericano de derechos humanos
Authors: Mier Galera David
Published: November 2024

En un contexto regional marcado por la falta de efectividad de los derechos, el nuevo constitucionalismo latinoamericano propone reforzar el hiperpresidencialismo. Además de aprobar cartas robustas de derechos, los líderes del nuevo constitucionalismo han procurado capturar a la justicia constitucional, la cual se ha revelado esencial para validar una estrategia destinada a concentra el poder en el presidente. Para ello, la justicia constitucional ha recurrido a la interpretación abusiva y desleal de la Convención Americana. La CIDH ha respondido reconociendo el derecho del juez a ser independiente, declarando la reelección presidencial indefinida incompatible con la Convención Americana, y reiterando el carácter obligatorio de sus sentencias, pero aun así la tutela efectiva de los derechos y del principio democrático exige reformas sistémicas en el SIDH.
AGRICULTURAL AND FOOD SECURITY COOPERATION AS A PATHWAY TO PEACE AND RECONCILIATION BETWEEN COUNTRIES
Authors: Sargsyan Nairi , Adkanian Alireza (Arik)
Published: November 2024

Peace and ways to achieve it have always been among the most important concerns of mankind. The age of war and peace is tied to human history. Food has been a human need since the beginning, and agriculture and food production have been integral throughout human history. There have been many wars over food, food resources, and agriculture.
However, the question addressed in this article is how to make food and agriculture a means to achieve peace. This has happened in the past, either after improving relationships between countries from enmity to friendship or, more rarely, during a time of transformation. There is still the possibility that this approach could become a component of peace agreements, making them stronger. Considering that no two cases are ever completely similar in historical events and human sciences, it is possible to propose a new theory or suggestion by examining the most correlations.
THE PRIMARY ISSUES WITH THE DEVELOPMENT OF ENTREPRENEURIAL ACTIVITIES IN THE RA SERVICES SECTOR
Authors: Khalatyan Harutyun
Published: November 2024

Maintenance services play a significant part in the RA economy and come in third place in terms of GDP formation, after industry and agriculture. Additionally, the country has seen an unparalleled expansion in service delivery in recent years, which creates significant difficulties for the management of commercial operations in the sector. In this context, it is critical to draw attention to the current issues with business operations pertaining to service delivery and offer solutions, which have been discussed in the article.
Particularly noteworthy are the insightful remarks made in the essay regarding RA-served solutions to issues pertaining to the sustainable development of services. Proposals were also made for the creation of high-caliber human resources and the innovative support of company operations, which creates prospects for the provision of services that meet international competitive standards.
Analisis Rasio Profitabilitas
Authors: Tasmita Yuni Nuardi
Published: November 2024

This study aims to determine the ratio of profitability at PT. Unilever Indonesia Tbk on the Indonesia Stock Exchange. The analytical method in this study uses a quantitative descriptive method using profitability ratio analysis using 3 measurements, namely return on assets, return on equity and net profit margin. The results of the profitability ratio analysis as measured using Return On Assets are considered very good because the average results achieved in 2018-2021 have exceeded industry average standards while profitability as measured using Net Profit Margin is included in the criteria quite good because the average results achieved in 2018-2021 are close to the industry average standard.
Partisipasi Masyarakat dalam Penerbitan Akta Kelahiran melalui Sistem Pelayanan Berbasis Digital
Authors: Haerati Haerati , Fatmawati Fatmawati , Mustari Nuryanti
Published: November 2024

This research aims to find out how the community participates in issuing birth certificates through the online-based service system at the Makassar City Population and Civil Registration Service. This research was carried out using the literature study method, which contains theories that are relevant to the research problem. The research was carried out by examining the concepts and theories used based on literature, related journals, supporting articles, and conducting direct observations at the Makassar City Population and Civil Registration Service office. The research results show that there are still many people who have not actively participated in issuing birth certificates through an online-based service system due to the public's lack of understanding of the online service system. The socialization carried out by the Makassar City Population and Civil Registration Service has not been optimal. It is hoped that the suggestions that can be given by researchers to the Makassar City Population and Civil Registration Service are to maximize outreach activities to the community by collaborating with various sectors that focus on public services to the community. The Makassar City Population and Civil Registration Service can also carry out activities that attract public attention so that community participation can be further increased.
PENERAPAN PERSETUJUAN TINDAKAN MEDIS DI GUNUNG SARI MEDICAL CLINIK
Authors: Bachri Syamsul , Nurnaeni Nurnaeni , Nabila An-Nur
Published: November 2024

Penelitian ini bertujuan untuk Penerapan Persetujuan Tindakan Medis di Gunung Sari Medical Clinic. Penelitian ini termasuk penelitian hukum empiris berdasarkan tipe pendekatan sosiologis, fakta, dan konseptual. Data bersumber dari hasil penelitian lapangan dan juga perundang-undangan. Sedangkan pengumpulan data dilakukan dengan teknik dokumentasi, wawancara dan studi pustaka. Hasil dari penelitian bahwa pelaksanaan persetujuan tindakan medis yang ada di Gunung Sari Medical Clinic secara yuridis sudah sesuai dengan ketentuan yang berlaku, dimana dalam pelaksanaannya lebih diutamakan pada proses komunikasi antara dokter dengan pasiennya, bukan hanya pada pengisian dan ditandatanganinya formulir. Jika muncul perbedaan pendapat antara dokter dengan pasiennya akan tindakan medis yang akan dijalankan, pihak tenaga medis dalam penyelesaiannya, tetap berusaha menghormati hak-hak asasi pasien dengan tetap memberikan layanan terbaik, memberikan alternatif tindakan lainnya meskipun hasilnya tidak maksimal dibandingkan tindakan medis yang telah disarankan, dan tidak menyuruh pulang paksa.
IMPLEMENTASI SISTEM MANAJEMEN KESELAMATAN KONSTRUKSI (SMKK) PADA PROYEK PEMBANGUNAN RS UPT VERTIKAL MAKASSAR TAHUN 2023
Authors: Muflihah A.Muflihah Darwis , Nurazizah  , Atjo Wahyu  , Mahfuddin Yusbud  , Muh. Yusri Abadi
Published: November 2024

63IMPLEMENTASI SISTEM MANAJEMEN KESELAMATAN KONSTRUKSI(SMKK) PADA PROYEK PEMBANGUNAN RS UPT VERTIKAL MAKASSARTAHUN 2023A. Muflihah Darwis1, Nurazizah2, Atjo Wahyu3, Mahfuddin Yusbud4, Muh. Yusri. Abadi51,2,3,4,5 Fakultas Kesehatan Masyarakat, Prodi Kesehatan dan Keselamatan Kerja,Universitas Hasanuddin* E-mail: amuflihah@unhas.ac.idAbstrakLatar belakang. Proyek konstruksi merupakan salah satu sektor usaha dengankompleksitas yang tinggi. Industri konstruksi menjadi salah satu sektor yang menyumbangangka kecelakaan paling tinggi dibandingkan sektor lainnya.Penerapan SMKK merupakansalah satu upaya perlindungan tenaga kerja dari risiko keselamatan dan kesehatan kerja.Tujuan. Penelitian ini bertujuan untuk mengetahui gambaran tingkat penerapan SistemManajemen Keselamatan Konstruksi (SMKK) pada proyek pembangunan RS UPT VertikalMakassar Tahun 2023. Metode. Penelitian ini merupakan penelitian kualitatif yangbersifat deksriptif observasional. Penelitian ini menggunakan lembar pemeriksaan SMKKsesuai dengan Permen PUPR No. 10 Tahun 2021. Analisis data dilakukan menggunakanaplikasi microsoft excel. Hasil. Berdasarkan hasil analisa data didapatkan tingkatpenerapan tiap elemen yaitu kepemimpinan dan partisipasi pekerja sebesar 91,6%,perencanaan keselamatan konstruksi sebesar 96,6%, dukungan keselaamatan konstruksisebesar 100%, operasi keselamatan konstruksi sebesar 98,7% dan evaluasi kinerjakeselamatan konstruksi sebesar 100%. Dari pembobotan masing-masing elemen tersebutdidapatkan nilai tingkat penerapan SMKK sebesar 97,6% atau berada pada kategori sangatbaik. Kesimpulan. Proyek pembangunan RS UPT Vertikal Makassar telah menerapkanSMKK dengan sangat baik dan memenuhi persyaratan yang berlaku
Effect of Strategic Leadership on the Performance of Nestle Foods Nigeria Plc
Authors: Asenge Emmanuel Lubem , Dewua Philip
Published: November 2024

The digital age has posed challenges to organizations in the 21st century. Strategic leadership is one of the most important problems that organizations are currently confronting. The investigation looked at how strategic leadership affected the performance of Nestle Foods Nigeria Plc. The research specifically examined how strategic direction setting, strategic core competencies, and strategic alignment affect the performance of Nestle Foods Nigeria Plc. A survey research design was utilized, and data were obtained from 32 company management staff using an online questionnaire. The data retrieved from the participants were analyzed using mean, standard deviation, and regression using the Statistical Package for Social Sciences (SPSS version 23). The results indicated that strategic leadership practices (strategic direction setting, strategic core competencies, and strategic alignment) positively and significantly affect firm performance. The study concludes that strategic leadership substantially affects the performance of the company. The study suggested, among other things, that the company's vision statement be revisited often to take into account newly emerging environmental dynamics. This would guarantee that the company's future goals are reflected in the vision.
The use of computer vision to differentiate valley fever from lung cancer via CT scans of nodules
Authors: El Kereamy Noor , On Vincent
Published: November 2024

Pulmonary diseases, notably lung cancer and valley fever, pose significant health risks. Therefore, a swift and accurate diagnostic tool is imperative. This study sought to harness advanced technologies, integrating computer vision techniques with computed tomography (CT) scans, to differentiate between lung cancer and valley fever, thereby enhancing diagnostic precision. We hypothesized that the MATLAB-based software tool developed would discern minute and distinct features of lung nodules specific to either lung cancer or valley fever with more precision than traditional diagnostics. Upon use of Otsu's thresholding and object size filtering, distinct morphological features were extracted from binary versions of the images. The MATLAB-based software consistently detected and differentiated lung cancer and valley fever based on the nodules' features, such as solidity, extent, and roundedness, among others. While size wasn't a consistent indicator as per previous studies, features like solidity showed great contrast between the distinct images. Overall, the software demonstrated promising potential in providing features to differentiate between two critical pulmonary diseases. However, a future study is needed with a larger number of images to further validate and refine the prediction algorithm prototype developed in this work, ensuring its accuracy for potential implementation in clinical settings. Once the technique is fully developed, it could reduce the chances of human error and expedite early detection and intervention. Future enhancements may incorporate other imaging modalities, promoting diagnostic capabilities. The study underlines the transformative role of machine learning-based analysis of CT scans in revolutionizing healthcare diagnostics.
PENGEMBANGAN REAKTOR SAMPAH UNTUK PENYELESAIAN MASALAH DI DAERAH URBAN: STUDI KASUS DI KOTA BANDUNG
Authors: Dzakiy Uruqul Nadhif , Pringgabayu Dematria , Hidayat Agus Maolana , Fadh Hottob Ahmad Sulthon , Purwandari Icha Sofia , Azizah Zaskia Nur , Akbar Subhan Syariifi
Published: November 2024

Reaktor sampah dapat membantu mengatasi masalah sampah di kota-kota, termasuk Kota Bandung. Reaktor hidrotermal adalah salah satu dari berbagai jenis reaktor yang kami rancang untuk mengubah limbah organik menjadi produk berguna yang memiliki nilai jual sebanding dengan pupuk dan pakan ternak. Masyarakat kelurahan Cangkuang Kulon, Kabupaten Bandung, yang berbatasan langsung dengan daerah sentra sepatu Cibaduyut Kota Bandung, akan menguji kesiapan dari reaktor ini. Pengujian ini mendapatkan hasil bahwa purwarupa alat ini berfungsi dengan baik di mana didapatkan hasil berupa alat pakan ternak seperti ayam dan bebek. Adanya alat ini diharapkan dapat menyelesaikan masalah sampah di kota-kota, khususnya sampah organik.
AKTIVITAS KOMUNIKASI PADA UPACARA RITUAL ADAT REBA MASYARAKAT KAMPUNG BAJAWA
Authors: Loparawi Mariano N. , Daga Lukas Lebi , Nafie Juan A. , Ara Roky K.
Published: November 2024

Masyarakat kampung Bajawa memiliki berbagai upacara adat. Salah satunya adalah upacara adat Reba yang hanya dilakukan oleh masyarakat Bajawa. Upacara adat Reba yang dilakukan oleh masyarakat kampung Bajawa dilakukan sebagai wujud syukur dan pernghormatan kepada leluhur dan Sang Pencipta, serta untuk mengevaluasi segala hal yang berhubungan dengan kehidupan bermasyarakat. Upacara adat ini juga bertujuan untuk memohon berkat serta penyertaan dari leluhur dan Sang Pencipta dalam menjalani tahun baru yang akan datang. Penelitian ini bertujuan untuk mengetahui aktivitas komunikasi ritual pada upacara adat Reba Penelitian ini dikaji menggunakan metode etnografi komunikasi dan teori interaksi simbolik hasil dari penelitian ini adalah aktivitas komunikasi ritual pada upacara adat Reba merupakan sebuah urutan tindakan dalam peristiwa komunikatif, dimana setiap tindakan tersebut memiliki makna tertentu. Komponen-komponen ritual pada upacara adat Reba yang merujuk pada media atau sarana yang digunakan dalam ritual merupakan bagian yang sangat penting, karena apabila media atau sarana tersebut belum disiapkan maka ritual tidak bisa dilakukan.
PEMANFAATAN MEDIA SOSIAL UNTUK VAKSINASI COVID-19 PADA MASYARAKAT KOTA KUPANG
Authors: Soba Maria Fransiskus Siga Rani , Mas'amah  , Aslam Muhammad
Published: November 2024

Pada era kemajuan industry teknologi dan digital pada saat ini penyebaran informasi melalui media menjadi sangat penting bagi masyarakat umum. Terkhusus dalam penyampaian informasi vaksinasi covid-19 di Kota Kupang yang dilakukan oleh salah satu instansi dibidang Kesehatan yakni RSUD Prof.Dr.W.Z. Johannes  Dalam masa new normal kerumunan adalah satu hal yang paling dihindari oleh masyarakat hal ini dikarenakan karna dapat menyebarkan virus covid-19, untuk menimalisir kerumunan maka pihak RSUD Prof.Dr.W,Z Johannes menggunakan salah satu cara dengan memberikan informasi tentang pentingnya vaksinasi covid-19. Pemerintah melalui instansi RSUD Prof.Dr.W,Z Johannes melakukan perencanaan untuk menjalankan strategi untuk memnfaatkan media informasi terkait dengan vaksinasi covid-19 pada masyarakat kota kupang. penelitian ini dilakukan dengan menggunakan konsep new media dengan menggunakan paradigma interpretative yang menghasilkan hasil penelitian yaitu : 1). Pihak RSUD Prof. Dr. W.Z Johannes Kupang sebagai salah satu instansi penyedia layanan vaksinasi bagi masyarakat memberikan kesempatan pada khalayak sebagai calon peserta vaksinasi dalam mendapatkan informasi mengenai  layanan penyedia vaksinasi melalui media sosial yaitu Facebook dan WhatsApp. 2). Hambatan yang ditemukan oleh RSUD Prof.Dr.W.Z. Johannes dalam melakukan  pelayanan vaksinasi kepada masyarakat adalah kurang stabilnya koneksi jaringan dalam melakukan pendataran online melalui link google form.
KOMUNIKASI VIRTUAL MAHASISWA PRODI ILMU KOMUNIKASI UNIVERSITAS NUSA CENDANA ANGKATAN 2020
Authors: Keko Rikardus , Wutun Monika , Aslam Muhammad
Published: November 2024

Penelitian ini bertujuan untuk mengkaji Bagaimanakah Komunikasi Virtual Mahasiswa Prodi Ilmu Komunikasi angkatan 2020  pada WhatsApp grup STORM’20 sehingga menghasilkan tujuan untuk Mendeskripsikan Faktor-Faktor Kontekstual Yang Mempengaruhi Komunikasi Virtual Pada WhatsApp Grup STORM’20 dan Mendeskripsikan Pola Komunikasi Pada WhatsApp Grup STORM’20. Dalam penelitian ini penulis menggunakan teori Computer Mediated Communication (CMC) dan jenis penelitian ini adalah penelitian kualitatif, menggunakan metode studi kasus. Pemilihan informan menggunakan metode purposive sampling dengan kriteria yang telah ditetapkan, informan penelitian berjumlah sembilan (9) orang. Pengumpulan data penelitian diperoleh dari wawancara, observasi dan dokumentasi. Teknik analisis data dengan mereduksi data, penyajian data, penyimpulan dan verifikasi. Serta uji keabsahan data dengan perpanjangan keikutsertaan dan ketekunan pengamatan atau keajegan pengamatan. Dari penelitian yang telah dilakukan, sehingga hasil penelitian yang didapatkan Faktor-faktor kontekstual yang mempengaruhi komunikasi virtual pada WhatsApp grup STORM’20 yakni, faktor peserta, topik, jenis saluran, lamanya, apakah sinkron atau ansinkron dan bagaimana sikap umum peserta terhadap komunikasi di internet. Dengan adanya faktor-faktor tersebut membuat komunikasi virtual yang terjadi di dalam grup WhatsApp STORM’20 dapat berjalan dengan baik antar sesama anggotnya ataupun dengan para senior mereka. Dan juga Pola Komunikasi pada WhatsApp Grup STORM’20 yang terbentuk adalah Pola Rantai, Pola Lingkaran, dan juga Pola Bintang atau Semua Saluran. Penelitian ini diharapkan agar para mahasiswa pengguna WhatsApp grup tidak selalu bergantung pada aplikasi yang tersedia sebagai media komunikasi virtual, tetapi mengutamakan komunikasi secara langsung sebagai komunikasi sehari-hari.
FORECAST THE USE OF TRAVEL WEBSITES USING THE THEORY OF PLANNED BEHAVIOR
Authors: Rangsom Kritiya , Khan-Am Wasun
Published: November 2024

Given the digital era's use of artificial intelligence (AI) in any field, the goal of this article is to investigate the use of the Theory of Planned Behavior (TPB) for forecasting travel websites utilizing AI applications. A total of 120 respondents who used both websites and chatbots were polled. The survey questionnaire elements were adapted from TPB and AI-enabled travel websites. Purposive random sampling was used to randomly assign the sample. Multiple regression analysis, correlation analysis, and descriptive statistics were utilized to investigate the acquired data. The results show that there are correlations among the variables that are included in the model framework. This study used TPB, as demonstrated by the regression equation: Y=0.07+0.46A+0.36S+0.16CB, with a strong R2 of 0.66. These findings demonstrate how well TPB understands and predicts user behavior in the context of AI-driven travel website usage.
Redistribución de planta de las áreas de trabajo de una marmolería mediante simulación, software FlexSim
Authors: García Castellanos Humberto , Ruiz García Cindy Guadalupe , Flores Enríquez Norma Yarisdi , Loera Castro Adrián Francisco
Published: November 2024

En esta propuesta se presentarán las técnicas para la distribución de áreas dentro de una marmolería. La empresa presenta un problema de distribución de planta ya que no se cuenta con un área asignada para cada máquina o proceso de trabajo.
Así mismo para que no se presente este tipo de problema, se propone asignarle un espacio determinado a cada máquina, representándolo por medio de un Layout hecho en el software AutoCAD, realizado con las medidas correspondientes de la empresa, una vez tomadas las medidas de cada espacio dentro de la marmolería, se realizará el Layout en AutoCAD, donde se representará con un color diferente cada área de trabajo.
Después de ello, una vez obtenidos los resultados del Layout en AutoCAD, se realizará una simulación en el software FlexSim, en el cual se volverán a representar las máquinas y los operadores propuestos, así como también el transporte desde la entrada de materia prima hasta convertirse en producto terminado.
El mármol es una piedra que se extrae de cerros, es utilizada para distintos fines, en este caso la empresa le da uso a las distintas placas para la elaboración de cubiertas en distintos sectores: industrial, hotelero y doméstico. Este tipo de trabajos da una vida más acogedora para el consumidor ya que son trabajos finos y brinda una estancia más cálida.
Udo Dannlowski: Brain structure and function in the long-term course of mental disorders
Authors: Dannlowski Udo
Published: November 2024

Udo Dannlowski is a psychiatrist, psychologist, and translational neuroimaging researcher whose work intersects clinical psychiatry, genetics, data science, and systems neuroscience. His academic endeavors are driven by a commitment to unraveling the complex biological and genetic mechanisms underlying long-term disease trajectories of affective disorders, including depression and anxiety. Dannlowski's use of brain imaging technologies, such as multimodal MRI, to explore the structural and functional anomalies in patients with these disorders in longitudinal cohorts over several years of follow-up with machine learning techniques has significantly advanced our understanding of brain mechanisms in mental disorders. Dannlowski is recognized for contributing to psychiatry and neuroscience, substantially impacting theoretical understanding and clinical practice. Since 2019, he has been heading the Institute for Translational Psychiatry in Münster, Germany, together with the clinical Section for Transition Psychiatry at the Department for Mental Health. We are privileged to present the Genomic Press interview with Professor Dannlowski, who has offered to share insights from his esteemed career and personal experiences for our readers' benefit.
Kim Q. Do: Antioxidants specifically targeted at mitochondria: A novel therapeutic approach to schizophrenia
Authors: Do Kim Q.
Published: November 2024

Kim Q. Do was appointed senior lecturer at the University of Lausanne (CH) in 2000. Over the years, she became an associate professor of translational psychiatry in 2011 and attained the position of full professor in 2017. In 1999, she established the Unit for Research in Schizophrenia at the Center for Psychiatric Neuroscience within the Department of Psychiatry at Lausanne University Hospital. She served as the head of this unit from 1999 until 2022. Additionally, she was the Center for Psychiatric Neuroscience director from 2013 to 2019. She holds visiting professor positions at Harvard Medical School in Boston, USA, the Institute of Psychiatry, Psychology & Neuroscience at King's College London, UK, and the Swiss Federal Institute of Technology Lausanne (EPFL). Professor Do graciously consented to participate in the Genomic Press interview, offering insights into her unique personal and professional journeys.
Carmine Maria Pariante: Understanding why and how stress makes us ill
Authors: Pariante Carmine M.
Published: November 2024

Carmine M. Pariante is Professor of Biological Psychiatry at the Institute of Psychiatry, Psychology and Neuroscience, King's College London, and Consultant Perinatal Psychiatrist at the South London and Maudsley NHS Foundation Trust. He investigates the role of stress and inflammation in the pathogenesis of mental disorders and in the response to psychotropic drugs, both in clinical and experimental settings. His work focuses on depression and fatigue, with a particular interest in the perinatal period and individuals with medical disorders. More recently, he has developed an interest in the effects of the arts, social prescribing, and nutritional interventions on mental health. Since 2018, Professor Pariante has been a Clarivate Analytics Highly Cited Researcher, and, as of April 2024, he has published >520 publications, with close to 40,000 citations and an H-Index of 103 in Scopus and 137 in Google Scholar. He is also the appointed Editor in Chief of the journal Brain Behaviour and Immunity and the Past President of the International Society for Psychoneuroendocrinology. Professor Pariante is also passionate about public engagement and has made many media appearances in newspapers, magazines, radio, and TV on topics broadly related to mental health, writing pieces for the Daily Mail, The Guardian, and the New Humanist. He can be followed on X and Instagram on @Pariantelab and the digital publication he edits, www.inspirethemind.org. It is gratifying to see Professor Pariante share insights into his professional and personal voyage during the Genomic Press interview.
Euripedes C. Miguel: Risk factors for obsessive-compulsive and other mental health disorders and their treatment and public policy implications
Authors: Miguel Euripedes C.
Published: November 2024

Euripedes Constantino Miguel is a full, tenured Professor and Head of the Department of Psychiatry at the Faculty of Medicine, University of São Paulo (FMUSP), and an Adjunct Associate Professor at Yale University School of Medicine. He graduated from FMUSP and completed his Psychiatry Residency and PhD at the Institute of Psychiatry at the University of São Paulo. After a postdoctoral fellowship at Massachusetts General Hospital, Harvard Medical School, Professor Miguel returned to Brazil in 1994 to pioneer the Obsessive-Compulsive Spectrum Disorders Program. He leads the National Institute for Developmental Psychiatry www.inpd.org.br, focusing on early identification and intervention of mental health disorders. Since 2023, he has led the National Center for Science and Innovation in Mental Health (CISM) www.cism.org.br, enhancing mental health education and research through innovative solutions and public-private partnerships. This Genomic Press Interview features Professor Miguel's candid reflections on his professional achievements and life's journey.
Annamaria Cattaneo: Three main questions: Stress, mental, and physical health: Is the gut microbiome the key? Which are the biological mechanisms driving perinatal depression, and how do they affect the mental and physical health of the offspring? Pharmacological and non-pharmacological interventions in reducing the risk of developing mood disorders or in improving symptomatology: Is inflammation the key driver?
Authors: Cattaneo Annamaria
Published: November 2024

Annamaria Cattaneo is an Associate Professor at the University of Milan, Department of Pharmacological and Biomolecular Sciences, and the Head of the Laboratory of Biological Psychiatry at the IRCCS Fatebenefratelli Institute in Brescia, where she is also Deputy Scientific Director. She is currently associate editor of Brain, Behavior, & Immunity—Health, an official journal of the Psychoneuroimmunology Research Society. She dedicates her research to understanding the complex interplay between early life adversities and the development of mental health disorders. Her work focuses on the biological mechanisms, such as neuroplasticity, inflammation, gut microbiome, and epigenetics, that connect early life experiences to mental health vulnerabilities later in life. Recently, Dr Cattaneo has expanded her research to explore the liver-brain axis and its role in the development of comorbidities between mental and physical disorders. Additionally, she is actively involved in identifying peripheral biomarkers associated with the risk of developing mood disorders and treatment response. A significant focus of her current work is on perinatal depression, aiming to uncover the biological, social, and environmental factors that shape the risk for depression during pregnancy and its impact on offspring outcomes. As the Coordinator of the HappyMums Project, a Horizon Europe initiative, she leads efforts to improve our understanding of the biological mechanisms underlying the development of depressive symptoms in pregnancy and the efficacy of interventions. Dr Cattaneo's passion for her work extends beyond the laboratory, as she actively engages in dissemination activities to raise awareness about mental health issues among the general population. Through events like the HappyRun in the Monza Park and Luci e Ombre / Lights and Shadows, she brings together science, art, and community to promote mental well-being. In this "Genomic Press Interview," Annamaria Cattaneo kindly shares insights into her life and impressive career, providing our readers with a glimpse into the driving force behind her ground-breaking research and tireless efforts to advance our understanding of mental health.
Ultra-short heart rate variability reliability for cardiac autonomic tone assessment in severe traumatic brain injury
Authors: Melo Hiago Murilo , Rangel Norma Beatriz Diaz , Fialho Guilherme Loureiro , Ribeiro de Carvalho Cristiane , Lin Katia , Walz Roger
Published: November 2024

This study compares heart rate variability (HRV) indices across different time epochs (5 minutes, 1 minute, and 30 seconds) to evaluate the reliability of ultra-short recordings for assessing cardiac autonomic tone 1 year after a severe traumatic brain injury (TBI). Electrocardiogram recordings were obtained from 48 patients 1 year after a severe TBI. Pearson correlation analysis was performed to evaluate the association between ultra-short HRV indices (1 minute and 30 seconds) and the standard 5-minute recordings. Additionally, ANOVA was used to compare the differences in mean HRV indices across the different epochs. The correlation analysis supports that time-domain indices present higher correlation coefficients (r = 0.63 to 0.99, p < 0.05) when compared with frequency-domain indices (r = 0.51 to 0.97, p < 0.05). The reduction in recording time increases the percentage variation of all indices. The root mean square of the successive differences of RR intervals (rMSSD) shows higher Pearson coefficient values and lower percentage variation at the 1-minute and 30-second epochs compared with other HRV indices. Ultra-short HRV indices are reliable for assessing cardiac autonomic tone in chronic patients who survived severe TBI. rMSSD was the most reliable HRV index for ultra-short recordings. The value of ultra-short HRV for cardiovascular prognosis after severe TBI remains to be determined in future studies.
A novel neurodevelopmental-neurodegenerative syndrome that cosegregates with a homozygous SPAG9/JIP4 stop-codon deletion
Authors: Acosta-Baena Natalia , Tejada-Moreno Johanna , Soto-Ospina Alejandro , Mejía-García Alejandro , Preciado Mauricio , Nanclares-Torres Jessica , Caro María Antonieta , Rojas Winston , Cardona-Gómez Gloria P. , Madrigal Lucía , Arcos-Burgos Mauricio , Villegas-Lanau Carlos Andrés
Published: November 2024

This report outlines the clinical features of a complex neurological phenotype shared by three siblings from a consanguineous family, characterized by intellectual disabilities, speech developmental delay, gait disturbance, cerebellar syndrome signs, cataracts, and dysmorphic features (square and coarse facial features, thick lips, deep palate, small and spaced teeth, low-set ears, strabismus, eyelid ptosis, and blond hair). Seizures and brain atrophy were later evident. In the cosegregation analysis, five family members and 12 family controls were studied by whole-exome and Sanger sequencing. The structural and functional effects of the protein were explored to define the mutated variant's potential deleterious impairment. Neurological and neuropsychological follow-ups and brain magnetic resonance imaging (MRI) were performed. We identified a single frameshift homozygous nucleotide deletion in the SPAG9/JIP4 gene (NM_001130528.3): c.2742del (p. Tyr914Ter), causing a premature stop codon and truncating the protein and originating a possible loss of function. The variant cosegregated in affected individuals as an autosomal recessive trait. The in silico protein functional analyses indicate a potential loss of 66 phosphorylation and 29 posttranslational modification sites. Additionally, a mutated protein structure model shows a significant modification of the folding that very likely will compromise functional interactions. SPAG9/JIP4 is a dynein-dynactin motor adapter for retrograde axonal transport, regulating the constitutive movement of neurotrophic factor signaling and autophagy-lysosomal products. Under stress conditions, it can potentiate this transport by the p38 mitogen-activated protein kinases (p38MAPK) signaling cascade. Both functions could be associated with the disease mechanism, altering the axon's development and growth, neuronal specification, dendrite formation, synaptogenesis, neuronal pruning, recycling neurotransmitters and finally, neuronal homeostasis—promising common mechanisms to be used with investigational molecules for neurodevelopmental diseases and neurodegeneration.
Circulating long noncoding RNA: New frontiers in biomarker research for mood disorders
Authors: Roy Bhaskar , Verma Anuj Kumar , Hulwi Ellie Marie , Dwivedi Yogesh
Published: November 2024

Unipolar and bipolar depression [major depressive disorder (MDD) and bipolar disorder (BD)] are complex psychiatric disorders characterized by disturbances in mood, affect, and cognition. Increasing evidence has confirmed epigenetic malfunctioning at the core of these two mental conditions; however, the exact molecular nature of that epigenetic maladaptivity is less known. Lately, long noncoding RNAs (lncRNAs) have emerged as essential epigenetic regulators of gene expression and cellular processes, offering new avenues for exploring the pathophysiology of mood disorders. In this report, we present a comprehensive review of recent clinical studies investigating the involvement of lncRNA in MDD and BD, and emphasizing their disease-specific contribution as potential biomarkers. We explore the dysregulation of specific lncRNAs detected in peripheral blood samples of individuals with mood disorders, while underscoring their significance for clinical diagnosis, prognosis, and predicting treatment response. Additionally, we provide future directions for lncRNA research in the context of mood disorders.
Anthony A. Grace: Elucidating the circuitries that underlie schizophrenia and depression may reveal the impact of stress during development and identify novel treatment targets
Authors: Grace Anthony A.
Published: November 2024

After finishing his postdoc at NYU in the Physiology Department under the direction of Rodolfo Llinas, Dr. Grace started as an Assistant Professor of Psychology and Psychiatry at the University of Pittsburgh in the fall of 1985. He was promoted early in the fall of 1991 to Associate Professor of Behavioral Neuroscience and Psychiatry and to Professor of Neuroscience and Psychiatry in July 2003. In September 2010, he was again promoted to Distinguished Professor of Neuroscience and Professor of Psychiatry and Psychology, his current position. He is the Editor-in-Chief of the International Journal of Neuropsychopharmacology, the journal of the Collegium Internationale Neuropsychopharmacologicum (CINP, International College of Neuropsychopharmacology). Dr. Grace has offered insights into his personal and professional journey.
Mayana Zatz: Two critical questions take center stage – Which variants mitigate the impact of lethal mutations in severe conditions with mild phenotype? What factors contribute to the health and longevity of centenarians?
Authors: Zatz Mayana
Published: November 2024

Mayana Zatz has been a Professor of Genetics at the Institute of Biosciences, University of São Paulo (USP), Brazil, since 1982. She became an assistant professor after a postdoc at the University of São Paulo and a second postdoc at the University of California, Los Angeles. Her current research is focused on neuromuscular disorders, aging, genomics, and, more recently, xenotransplantation and the use of the Zika virus as an oncolytic therapy against brain tumors. Functional studies are done in genetically engineered mouse and cell models. She is particularly interested in investigating protective mechanisms in rare patients with Duchenne dystrophy and a milder clinical course, as well as in centenarians' health determinants. Mayana Zatz is also involved in ethical aspects of genomic studies and government political decisions related to science. Professor Zatz is pleased to offer our readers insights into her personal and professional experiences.
Robin Dunbar: The neurobiology of human sociality
Authors: Dunbar Robin
Published: November 2024

Robin Dunbar is an eminent evolutionary psychologist and anthropologist whose pioneering work has permanently redefined how we think about human social relationships. Dunbar, who is an emeritus Professor of Evolutionary Psychology at the University of Oxford, became world-renowned for, among other contributions, his formulation of “Dunbar's number,” a theoretical limit to the number of stable social relationships an individual can maintain, typically cited as about 150. That idea, which he developed as he studied the relationship between brain size and social group size in various primate species, has since had broad influences across areas from social media design to organizational management. Over time, Dunbar's number has become more widely known and discussed, particularly with the advent of social media and online social networks. This has led to renewed interest in its implications for digital social interactions. Dunbar's illustrious career spans multiple prestigious institutions, including, prior to joining Oxford in 2007, the University of Cambridge, the University of Stockholm (Sweden), University College London and the University of Liverpool. He is a fellow of the British Academy and the Royal Anthropological Institute, a Foreign Member of the Finnish Academy of Science and Letters, and an elected Honorary Member of the Hungarian Academy of Sciences. His interdisciplinary expertise is reflected in his professorships in psychology, evolutionary biology, and anthropology at institutions such as Liverpool and Oxford Universities. He has held a visiting chair in statistical physics and computer science at Aalto University, Finland, which has also awarded him an honorary doctorate. Dunbar studies the evolution of social processes in primates and humans, with work that blends neurobiology, cognitive science, and the social dynamics of how we communicate via friendship networks. His insights into friendships and community cohesion continue to shape our understanding of human social behaviour in the digital age. It is an absolute pleasure that Professor Dunbar answered the Genomic Press Interview as we celebrate the extraordinary story of his scientific odyssey with our readers.
Bernard Lerer: Pre-clinical, translational and clinical research focused on the use of psychedelic drugs and their derivatives to treat psychiatric disorders
Authors: Lerer Bernard
Published: November 2024

Professor Bernard Lerer is in the Faculty of Medicine, Hebrew University, Jerusalem, Israel, where he is Director the Center for Psychedelic Research (https://cfpr.brainlabs.org.il/) at Hadassah Medical Center, in Jerusalem. The Center has a growing staff that includes senior scientists, post-docs, Ph.D. and graduate students, technicians, and psychiatrists undergoing research training. Their research is preclinical, translational, and clinical and focuses on the use of psychedelic drugs and their derivatives to treat psychiatric disorders. Previously, he was Head of the Biological Psychiatry Unit at Hadassah Medical Center for 30 years, with research and clinical responsibilities. A conversation with Professor Lerer covered topics on his life and career.
The Birth of the Dark Child
Authors: Shepherd Sherry Thorn
Published: November 2024

This author describes her experience as a therapist in holding the containment of the birth of the dark child, a dark-skinned mother or a dark woman acting as protector. She clarifies that this is the work of North Americans in her practice, and could be "culturally variable." The work of Meister Eckhart is quoted, with The Via Creativa as the Breakthrough stage, the birth of the self, or a part of the personality that one is not acquainted with, prompting a powerful experience between therapist and sandplayer. Jung is quoted to say that the child is "the product of the conjunction of the unconscious and consciousness," prompting some spiritual change. These transformational symbols unify spirit and psyche, prompting creativity.
"Home" and "Career" Women—Initial and Final Scenes
Authors: Bradway Kay
Published: November 2024

The initial and final sand scenes of 10 women, 5 identified as "Home Women" and 5 as "Career Women" are presented and discussed. Home women (median age of 40) were married and not employed outside the home. Career women (median age of 30) were active in helping professions and not married. Comparisons: Initial scenes of the two groups show marked differences in assertiveness and aggression, with the career women being more aggressive and home women more passive. Final scenes of both groups show more balance and wholeness. Discussion of the psychology of women in the 1970s, which was when these women were seen, is included.
Ibn Rusyd Mempertemukan Agama, Filsafat dan Sains Relevasinya dengan Pendidikan Islam
Authors: Asnawan Asnawan , Amaliano Adam Gio , Nudin Ihwan , Ghoni Mohammad Wafa’ul , Rofik Muhammad
Published: November 2024

Ibnu Rusyd merupakan salah satu tokoh filsuf yang berupaya menggabungkan antara agama dan filsafat dengan berlandaskan prinsip-prinsip ajaran Islam, seperti pendapat beliau bahwa filsafat tidaklah bertentangan dengan islam, bahkan orang islam diwajibkan atau sekurang-kurangnya dianjurkan untuk mempelajarinya. Penelitian ini ingin mengetahui upaya-upaya ibn rusyd dalam mempertemukan agama, filsafat dan sains serta ingin mengetahui relevansi pemikiran ibn rusyd mempertemukan agama, filsafat dan sains dalam kehidupan sekarang. Metode yang digunakan adalah content analysis yaitu metode penelitian yang memanfaatkan seperangkat prosedur untuk menarik kesimpulan yang sahih dari sebuah buku dan dokumen. Analisis terhadap pemikiran-pemikiran Ibn Rusyd dalam menyelaraskan agama, filsafat, dan sains, dengan cara membuat klasifikasi pembenaran berdasarkan tingkatan kapasitas pemahaman keagamaan kaum Muslimīn, secara substansial akan menemukan titik simpul. Karena pada dasarnya, pemahaman seseorang terhadap agama pada tingkatan tertentu tidak akan terlepas dari fungsi akal yang sebagai promotor suatu pemikiran yang rasional. Tanpa akal seseorang tidak akan dapat menerima kebenaran agama, meskipun dalam tingkatan “rasional” yang rendah. Hal ini menunjukkan bahwa hubungan kebenaran rasio dan agama tidak akan pernah bertentangan, yang bisa bertentangan adalah pemahaman manusia terhadap isi kandungan yang di bawa oleh wahyu.
PELATIHAN WIRAUSAHA BUDIDAYA IKAN LELE MENGGUNAKAN PAKAN ALTERNATIVE DI PONDOK PESANTREN ASSUNNIYYAH KENCONG KABUPATEN JEMBER
Authors: Syaikhu Ach , Maulana Achmad Lana , Mukti Abdul , Ilahi Sri Kurnia , Kholil Mochammad , Akmal Ahmat Maulana
Published: November 2024

Program Kreativitas Mahasiswa (PKM) ini bertujuan untuk meningkatkan efisiensi budidaya lele di Pondok Pesantren Assunniyah dengan solusi pakan alternatif berbasis maggot Black Soldier Fly (BSF). Kendala utama yang dihadapi oleh pelaku UMKM dalam budidaya lele adalah tingginya biaya pakan. Oleh karena itu, maggot BSF, yang kaya protein dan mudah dibudidayakan dengan memanfaatkan limbah organik, diperkenalkan sebagai pakan alternatif yang lebih ekonomis dan ramah lingkungan. Hasil dari pelaksanaan program ini menunjukkan bahwa penggunaan maggot BSF dapat menekan biaya produksi hingga 30-40% dan mendukung pertumbuhan lele yang optimal. Selain itu, program ini memberikan keterampilan baru kepada santri dalam budidaya maggot dan pengelolaan limbah organik, sekaligus meningkatkan kesadaran lingkungan. Program ini berpotensi memberikan kontribusi positif bagi pemberdayaan ekonomi dan peningkatan keterampilan masyarakat, serta dapat diperluas ke komunitas lainnya untuk meningkatkan keberlanjutan usaha dan ketahanan pangan.
Egy reprezentációs forma változatai – Zsigmond-kori csempés és oszmán-török szemes kályhák a csókakői várban
Authors: Hatházi Gábor , Kovács Gyöngyi
Published: November 2024

A csókakői vár (Fejér vármegye, móri járás) 1997 óta zajló feltárása 2017-ben fejeződött be (1. ábra 1–3), így az utóbbi években nagyobb lendületet vett a leletanyag feldolgozása.1 Munkánk során prioritás a vár tárgyi emlékeit ugyanazon súllyal kezelni, mint az épített emlékeket: azon céllal és igénnyel, hogy e leletanyag ne csak az építészettörténeti időrend támpontjául szolgáljon, hanem a vár mindenkori lakóinak anyagi kultúrájáról és életmódjáról is minél teljesebb összképet, egyfajta korszakonkénti „szociokulturális látleletet” is nyújtson. Érdekes szelete a kérdéskörnek a reprezentáció. A 13–17. század folyamán mindvégig használt csókakői vár különböző korszakaiban ennek megnyilvánulási formái (bizonyos időszakokban a teljes hiányuk, avagy – meglétük esetén – azok jellege és mértéke) jelentősen eltértek egymástól, jelezve az erősség (valamint birtokosai, elöljárói) súlyának és különböző funkcióinak időről-időre beálló változásait, a hangsúlyok eltolódásait. E tekintetben a csókakői leletanyag egyik legfigyelemreméltóbb tárgycsoportja a kályhacsempe- és kályhaszemanyag. Az abból kiolvasható tendenciákra fókuszáló alábbi tanulmányunkkal szeretnénk köszönteni a jelen kötet ünnepeltjét, a számos más kutatási terület mellett a székelykeresztúri kályhacsempék régészét.
„Das Kind hat mehr Zeit als wir.“ Zeitwahrnehmung bei Kindern und Erwachsenen in Michael Endes Momo
Authors:   Universitatea din București, Karlstedt Ana
Published: November 2024

The concepts of time and time perception are crucial in this article. Moreover, the fact that time is perceived differently from children to adults is exemplified through theory and practice. The main object of analysis is the cult classic fantasy novel Momo by Michael Ende. Published in 1973, the book emphasizes the fact that children and adults have different visions and different usage of time. While children seem to have time in abundance, focusing on play and fun ways to spend it, adults fear they don’t have enough time on their hands. Michael Ende proposes a possible worlds dystopic scenario in which relentless and cunning so-called time-thieves have power over human time. It is only little Momo with her unique, effortless approach to temporality that can save humankind from extinction. Counting on his readership being entertained by his book, Michael Ende’s novel also has the power to make us highly aware of the consequences of poor time management. For this reason, the following article also ponders over the moralizing aspects of this timeless novel.