bluuebunny/crossref_metadata_2025 huggingface dataset:
The Challenge of Energy Efficiency in Social Housing: An Evaluation of Envelope's Improvements and their Economic Effects
Authors: Barreto Patricia , Vieira Saul , Có Márcio Almeida , Muniz Pablo Rodrigues
Published: October 2024

Objective: This study aims to propose a combination of modifications to the envelope of a Social Housing (SH) project and evaluate their impacts on thermal load reduction and cost increase, staying within the budgetary constraints.
 
Theoretical Framework: The Minha Casa Minha Vida Program (PMCMV) prioritizes architectural solutions focused on large-scale production and reduced unit costs, at the expense of environmental comfort and energy efficiency. However, efforts to raise the standards of habitability and quality of life are evident in the new 2023 program version and its regulations for new projects.
 
Method: This case study assesses the envelope classification of an SH project applied to 20 sets of construction modifications and 4 deployment orientations, using the Inmetro Normative Instruction for Building Energy Efficiency (INI-R). Thermal load reduction and cost increment analysis will be performed.
 
Results and Discussion: For each deployment orientation, the modifications that resulted in the greatest reduction in thermal load. This reduction ranged between 20% and 26.5% for the four orientations, with an additional cost ranging from 6% to 16%.
 
Research Implications: Energy efficiency measures, even if they entail higher costs, may provide economic benefits during the operation and maintenance phases of the properties within PMCMV standards.
 
Originality/Value: This study contributes to the dissemination of the simplified method of INI-R for envelope analysis in buildings and may influence improvements in public policies related to environmental quality in housing programs.
УКРАЇНСЬКА АНТРОПОНІМІЯ ХVІІ СТ. У МАЛОВІДОМОМУ ТУРЕЦЬКОМУ ІСТОРИЧНОМУ ДЖЕРЕЛІ. IX
Authors: КУПЧИНСЬКА ЗОРЯНА
Published: October 2024

Статтю присвячено дослідженню українських антропонімів XVІІ ст., які засвідчені в маловідомому турецькому історичному джерелі «Дефтер Муфассал 1681 року». Простудійовано власні назви людей у межах М – Mavrunejko. Антропоніми, що репрезентовані в «Дефтері», свідчать про їхню архаїчність, адаптацію запозичених імен на україномовному ґрунті. З 91 дослідженої назви засвідчено такі, які: поширені і сьогодні на рівні власних імен людей і прізвищ; мають відмінності зі сучасними відповідниками на фонетичному рівні; не виявлені на сучасному етапі, знаходимо їх у похідних назвах. У результаті розвідки було встановлено особливості антропонімії, що виділена з турецької пам’ятки «Дефтер Муфассал 1681 року», зокрема це історичне джерело засвідчує функціонування прізвищевих назв в Україні на кінець ХVII ст., репрезентований список антропонімів у межах М – Mavrunejko підтверджує, що у ХVII ст. існував обширний реєстр запозичених власних імен, які адаптувалися на українському мовному ґрунті; законстатовано великий спектр різноманітних суфіксів, за допомогою яких творилися похідні імена/прізвиська/прізвищевої назви.
Evaluation of WEPP and Its Comparison with USLE and MUSLE in Yozgat-Kadılı Village
Authors: Demir Saniye , Şimşek Halis , Kaya Yağmur
Published: October 2024

The water erosion is a significant environmental issue in arid and semi-arid regions. It leads to soil degradation, reduced agricultural productivity, and desertification. This article used The WEPP, the USLE, and the MUSLE models to estimate the average soil loss in the Yozgat-Kadılı village. Also, The MUSLE model utilized the WEPP model-estimated runoff for soil loss estimation. The USLE model, which estimates soil erosion using six factors (R, K, L, S, P, and C), can be improved by incorporating the Modified Fournier Index (MFI). Results indicated that the MUSLE model (3.66 t/ha) performed well in estimating soil losses close to the observed value (3.15) in the wheat fields between 1986-1996. the MUSLE (5.31 t/ha) and WEPP (5.88 t/ha) models underestimated soil losses to the observed value (8.75 t/ha) in the fallow field for 1986-1996. The WEPP model estimated the highest average soil loss at 5.18 t/ha in a wheat field, while the USLE model yielded the lowest estimate at 1.28 t/ha between 1969 and 2020. The MUSLE model estimated the highest (4.94 t/ha) and The USLE model estimated the lowest (2.53 t/ha) soil loss in the fallow field between 1969-2020. Results also revealed that the WEPP model is needed to calibrate for estimating soil loss in arid and semi-arid regions.
Intensity of Adoption of Improved Malt Barley Production Technologies in Ethiopia: A Case Study in Oromia Region
Authors: Bezabeh Ali Addisu , Mohammed Jema Haji
Published: October 2024

Improved malt barley production technology packages are not yet widely adopted in Ethiopia. Stakeholders, including brewers, malt factories, research institutes, and farmer-based organizations, have been collaborating and promoting new malt barley production technologies in order to boost the intensity of acceptance. The aim of this study was to find out the intensity of improved malt barley production technologies adoption in Arsi zones, Oromia region, Ethiopia. A stratified random sampling approach with multiple stages was employed to collect primary data from 384 malt barley household heads. The data was analyzed using descriptive statistics, and the intensity of adoption of improved malt barley production technologies was determined using an econometric Tobit regression model. The findings specified that the most adopted improved malt barley variety was Traveler (47.92%), which was followed in descending order by Iboni (14.58%), Sabini (9.38%), Grace (5.47%), Holker (4.43%), and 18.23% unnamed varieties. The Tobit model result also depicted that the intensity to which improved malt barley varieties adopted were affected by, taking into account factors including contract farming involvement, cooperative membership, off-farm income, size of livestock holdings, access to training, and mobile ownership. Enhancing farmers’ knowledge of the advantages of contract farming, income diversification, and mobile phone-based information delivery are among the many ways to support access to and accelerate the adoption of improved malt barley technology in the research area and beyond.
Physicochemical, Nutritional, and Antioxidant Properties of Ice Cream Enriched with Red Beetroot (Beta vulgaris L.) at Varying Sucrose Levels
Authors: Hacıbektaşoğlu Firdevs , Gündoğdu Engin
Published: October 2024

This study aims to produce a low-calorie ice cream with a higher nutritional value using red beetroot (Beta vulgaris L.). Four kinds of ice cream containing 5%, 10 % and 15% sucrose and single red beetroot (RB) ratio 15% and control (15% sucrose+ RB free) encoded as RB5, RB10, RB15 and C were produced respectively. The addition of RB increased pH and decreased the acidity (LA) and dry matter contents compared to control. Ash content was decreased depending on the sucrose ratio. While the lowest overrun value was determined in the RB10 sample (23.08%), the highest was in sample C (39.18%). The increasing of sucrose ratio generally increased the first dropping time and decreased the total melting time. The addition of sucrose reduced the viscosity and the highest viscosity values were observed in the sample RB5. While the lowest total phenolic content (TPC) was observed in the control sample (329.69 GAE mg/kg), the highest TPC was found in the RB5 sample (558.55 GAE mg/kg). Also, the lowest DPPH value was determined in the control sample (13.66% inhibition), the highest DPPH value was determined in the RB10 sample (27.98% inhibition). While fructose and glucose values decreased, sucrose values increased in the ice cream samples depending on the increasing of sucrose ratio.
Used in Urban Area for Landscape Planning and Design Spatial and Temporal Variations in Chromium (Cr) Concentrations in Picea orientalis L.
Authors: Zeren Çetin İlknur
Published: October 2024

This study investigates the spatial and temporal variations in chromium (Cr) concentrations in Picea orientalis L., across different directions (north, east, south, and west) and plant organs (outer bark, inner bark, and wood) in a forested region. The research, conducted over eight age periods spanning 1980 to 2020, aimed to assess the effectiveness of Picea orientalis L. as a biomonitor for Cr pollution. The highest Cr concentrations were observed in the east direction, particularly in the inner bark and wood, while the lowest levels were found in the west. The study was conducted in an urban area near the industrial zone and highway, as well as in forested regions. A total of 100 trees were selected for the study, with samples collected from three different organs: outer bark (OB), inner bark (IB), and wood. Samples were taken from each organ at breast height (approximately 1.3 meters above the ground) to ensure consistency. The sampling covered various age periods, specifically 1980–2020, to analyze temporal changes in Cr concentrations. Statistical analysis revealed significant variations in Cr concentrations across most directions and periods, with notable increases during certain periods, especially in the west direction. These variations can be attributed to several factors, including the proximity to industrial sources of pollution, which typically release higher levels of chromium into the environment. The eastern direction likely experiences greater exposure to these emissions due to prevailing wind patterns and urban runoff, leading to increased accumulation in Picea orientalis L. Additionally, seasonal changes, temperature fluctuations, and soil characteristics may influence the bioavailability of chromium, affecting its uptake by the tree. The results suggest that Picea orientalis L. can effectively reflect Cr pollution levels, with significant directional and temporal variations that highlight the influence of these environmental factors on Cr accumulation. This study underscores the potential of Picea orientalis L. as a valuable tool for monitoring and managing Cr pollution in forested environments.
Quality Determination of Dairy Farm Wastewater in Dinajpur
Authors: Islam Motaharul , Mst. Taslema Nasrin  , Md. Mofizul Islam
Published: October 2024

At present environmental pollution is a talked about issue. Due to environmental pollution, humans and animals face threats. The scientist has pointed out that waste is one reason for climate change. Solid, liquid, gaseous etc. are different types of waste. The experiments were conducted to determine the chemical constituents present in dairy farm wastewater, wastewater management practice and environmental impact and compare it with the groundwater Dinajpur Sadar upazila. The data concerning the dairy farm wastewater in Dinajpur was obtained through a designed questionnaire, and separate area inspection interacting with the proprietor and workers in the dairy farm. Randomly collected samples from different dairy farms. The chemical constituents of the wastewater sample were determined by a laboratory experiment. The wastewater contained Mg, Na, Ca, Cl-, K, EC, P, HCO3-, pH, TDS, DO, COD, Zn, S, BOD, HT and NO3-. The Na, K, Ca and pH concentration of wastewater under the range in groundwater in Dinajpur. However, concentrations of P, TDS, Mg, EC, Cl-, HCO3- and HT are above the groundwater range in Dinajpur. The produced wastewater was disposed of either through drainage or piping systems on fellow land, ponds, open lakes, roadside land, urban drains, and rivers. The unplanned wastewater disposal creates bad odor, and environmental pollution, seduces the growth of mosquitoes decreases the water quality, soil quality and health hazards. Therefore, it can be concluded that the prevailing dairy farm wastewater disposal system not being satisfactory. The proper disposal system should be improved to reduce environmental impacts.
The Spectrum of Thyroid Lesions on Cytology in a Secondary Care Centre, Karkala, Karnataka
Authors:   Kasturba Medical College, R Shetty Rashmi
Published: October 2024

Fine Needle Aspiration Cytology (FNAC) is a cost effective, minimally invasive procedure with less complications. It can be used in the diagnosis of thyroid lesions, aiding the clinician in the patient management and reducing the incidence of unnecessary surgeries. Thyroid profile test, ultrasonography and radionuclide scan are used as adjuvant diagnostic modalities.
Low-intensity aerobic training reduces macrophages infiltration and improves morphological characteristics of soleus skeletal muscle from mdx mice
Authors: Antão Rosangela , Sigoli Emilly , Chesca Deise Lucia , Oliveira Passos de Araújo Tatiana , Cornachione Anabelle Silva
Published: October 2024

Duchenne Muscular Dystrophy (DMD) is characterized by the absence of the dystrophin protein. The absence of this protein determines recurrent injuries in muscle tissue progressing to necrosis and generalized weakness, leading to the patient’s death due to respiratory and/or cardiac failure. There is no cure for DMD. However, some exercise programs could minimize the disease's progression. Low-intensity training has been used as a rehabilitation program for dystrophic muscles, although the effects are still unclear. This study aimed to analyze the effects of low-intensity aerobic training on the general morphological aspects of the skeletal muscle of mdx mice.  Eighteen male mice were divided into three groups with six animals each: (mdx sedentary, mdx trained, and wild-type sedentary). The low-intensity training was performed on a treadmill running during the 37 sessions. After the experiments, the animals were euthanized, and the soleus muscle was excised for histological and immunofluorescence analyses. The training (37 sessions) showed an improvement intoning the morphological aspects of soleus mdx mice and a reduction of macrophage infiltration. The low-intensity training can minimize the inflammatory process and reverse morphological alteration in the soleus muscle of the mdx mice.
Queer Narratives and Colonial Injustice: Tropical Landscape in The Brief Wondrous Life of Oscar Wao
Authors: Samal Prabhudutta , Samantaray Swati
Published: October 2024

This paper explores the intersection of colonialism, masculinity, and queerness in Junot Díaz’s The Brief Wondrous Life of Oscar Wao. Through a decolonial lens, it examines how Díaz critiques the lingering effects of colonialism and dictatorship on Dominican identity, particularly through the ‘fukú’ curse—a symbol of intergenerational trauma. The paper argues that the queering of heterosexuality in the novel challenges rigid gender norms, where Oscar’s nonconformity and Yunior’s conflicted hypermasculinity expose the limitations of Dominican masculinity shaped by colonial rule. Set against the backdrop of the Dominican Republic’s tropical landscapes and violent history, Oscar’s and Yunior’s narratives highlight the broader struggle between individual authenticity and societal conformity. Díaz’s use of magical realism and transcultural storytelling amplifies this decolonial critique, revealing how colonial legacies continue to shape gender and identity in the post-colonial world. By analyzing the characters’ resistance to heteronormative pressures and their individual journeys, the paper situates The Brief Wondrous Life of Oscar Wao as a significant exploration of queering as a form of decolonial resistance, reconsidering the lasting impact of colonial oppression on cultural and gender identities.
Intersection of Queerness, Disease, and Tropics: Walking the Streets of Anosh Irani's ‘The Parcel’
Authors: Neelofar Shafi  , Peerzada Owais Adil  , Priyanka Prachi
Published: October 2024

This paper provides an analysis of Anosh Irani's novel The Parcel, with a particular focus on queerness and disease within the Hijra community of prostitutes in the tropical setting of Kamathipura, the notorious red-light district of Mumbai, India. The paper delves into the novel's nuanced portrayal of queerness, exploring how it intersects with the theme of disease within the tropical milieu. Extending the theoretical works of Elizabeth Outka on disease, and Erving Goffman on stigma to the queer tropics, the study explores how these elements interact and influence the lived experiences of the Hijra community. The paper highlights how the novel presents contagion and disease as a pervasive aspect of the characters' lives, shaping their experiences and identities. The tropical enclave of Kamathipura is examined for its role in compounding the challenges faced by the Hijra community, including health disparities and social stigma. This study contributes to literary scholarship on queerness and health in the Indian tropics, offering a deeper understanding of the realities faced by marginalized communities.
Aleitamento materno e adesão vacinal nos primeiros seis meses de vida
Authors: Ribeiro Myllena Maciel , Costa Júlia Silva , Rogério Vitória Valadares , Neves Milene Garcia , Pires Catarina Amorim Baccarini
Published: October 2024

Objetivo: Avaliar o perfil clínico de mães e crianças nos primeiros seis meses de vida e o perfil epidemiológico do aleitamento materno exclusivo e não exclusivo, da vacinação, da presença de infecções respiratórias, de sintomas do trato gastrointestinal e do ganho de peso dessas crianças. Métodos: Trata-se de um estudo descritivo, do tipo coorte prospectivo e retrospectivo. Os dados foram obtidos por meio de questionários enviados mensalmente para mães do Vale do Aço - MG ao longo dos seis meses de pesquisa. Resultados: O estudo iniciou com 36 mães e ao final da pesquisa haviam 23 mães participantes. Os resultados revelaram que a ocorrência de infecções respiratórias não teve uma mudança significativa em sua frequência ao longo dos seis meses e a diminuição na taxa de vacinação não foi estatisticamente relevante. No entanto, a presença de sintomas gastrointestinais mostrou uma redução significativa em sua incidência. Conclusão: O estudo atual evidencia uma relação estatisticamente significativa entre a prática do aleitamento materno exclusivo e a diminuição das taxas de sintomas gastrointestinais durante os primeiros seis meses de vida do bebê. Isso reforça a importância da amamentação exclusiva nos primeiros meses como um fator protetor.
Genetic analysis of drug resistance mechanisms and phylogenetic clustering in Candida auris isolates from Western India
Authors: Chheda Pratiksha , Shivaprakash Shashikala , Gupta Naina , Dama Tavisha , Biyani Neetu , Bansode Seema
Published: October 2024

Objectives:

Candida auris is an emerging multidrug-resistant fungal pathogen that poses a significant threat to global health. Limited information is available from the Indian subcontinent regarding mutations associated with drug resistance and genetic variability among the isolates. In this study, we employed whole-genome sequencing (WGS) to investigate the genetic variations and drug resistance mechanisms within C. auris isolates from the western region of India.

Materials and Methods:

A total of twenty archived isolates were subjected to WGS on the Illumina NextSeq 2000 platform. A set of 18 genes was analyzed to check for the presence of drug-resistant mutations. Phylogenetic analysis was done using MEGA v6.06 software to identify the C. auris subgroup or clade and to check genetic relatedness among species.

Statistical analysis:

The data related to drug resistance were presented in numbers and percentages.

Results:

Through manual analysis, drug-resistant mutations were detected in ERG11, CDR1, and TAC1b genes, which are known to be associated with reduced susceptibility to antifungal agents. Phylogenetic analysis revealed that all the isolates clustered within Clade I, indicating a high degree of genetic similarity among isolates. The absence of comprehensive antifungal mutation databases and automated tools for drug resistance detection necessitated the utilization of specialized computational skills of bioinformaticians for data analysis.

Conclusions:

The study provides valuable insights into the genetic diversity and drug resistance mechanisms of C. auris isolates in the western region of India and emphasizes the need for continued research and surveillance to combat this emerging pathogen. Our findings underscore the need for the development of user-friendly automated tools and comprehensive databases to facilitate rapid and accurate identification of drug resistance in C. auris.
The Pivotal Role of Negative Pressure Wound Therapy in the Management of Enteroatmospheric Fistula: A Year-Long "Obstacle Marathon"
Authors: Porfidia Raffaele , Grimaldi Simona , Ciolli Maria , Picarella Pietro , Grimaldi Sergio
Published: October 2024

Background. Enteroatmospheric fistula (EAF) is an abnormal communication between the gastrointestinal tract and the atmosphere. This phenomenon is still considered one of the most significant challenges faced by general surgeons after abdominal surgery. Primary goals of managing EAF include controlling and diverting intestinal contents outside the abdominal cavity, protecting surrounding tissues from retraction, and promoting wound healing. Achieving these goals is not easy. EAF has a 40% mortality rate. Several techniques have been proposed for managing this problem, including negative pressure wound therapy. The use of bladder catheters, nipples, endoscopic stents, vascular grafts, and fistula funnel, among other options, in the management of EAF has also been described. Case Report. The patient in the current report underwent Hartmann reversal surgery. On postoperative day (POD) 5, he had an anastomotic leak with ischemia of the descending colon and the transverse colon. Resection of the ischemic colon was performed, followed by creation of a terminal ileostomy on the last ileal loop on the right side. The first small orifice of EAF appeared on POD 23, the second on POD 28, and the third on POD 45. On POD 253, the patient underwent resection of the fistulated loop, extensive vitreolysis of the entire small intestine, and mechanical jejunojejunal laterolateral anastomosis to reestablish the canalization toward the previous terminal ileostomy on the right side. Complete closure of the skin was evident on POD 358. Conclusion. There is no ideal treatment approach that is valid for all cases of EAF. Spontaneous closure of an EAF is unlikely but feasible in the setting of a single, deep lesion with limited output and when intestinal continuity is preserved.
Случай гипертрипсиногенемии при частичной трисомии хромосомы 13
Authors: Репникова А.Р. , Прокопцева Ж.В. , Ким М.Д. , Галиуллина Г.Р. , Костырко Э.И. , Самсоненко М.С.
Published: October 2024

Неонатальная гипертрипсиногенемия (при скрининговом и ретестном исследовании в 21–28 дней жизни в группе риска) должна расцениваться не только в качестве диагностического критерия муковисцидоза, но и как признак других заболеваний и состояний у новорожденного, в том числе структурных хромосомных аномалий. Это поможет своевременно диагностировать патологию и корректировать лечебные мероприятия в более раннем возрасте. В статье описан клинический случай гипертрипсиногенемии при частичной трисомии 13 хромосомы. Также рассмотрены возможные причины повышения иммунореактивного трипсина в рамках неонатального скрининга. Приведены данные ретроспективного анализа историй болезни пациентов с гипертрипсиногенемией.

Neonatal hypertrypsinogenemia (in screening and retest) should be regarded not only as a marker of cystic fibrosis, but also as a sign of other diseases and conditions, incl. structural chromosomal rearrangements. This will help to diagnose pathology in a timely manner and correct therapeutic measures at an earlier age. The article describes a clinical case of hypertrypsinogenemia with partial trisomy of chromosome 13. Various reasons for the increase in immunoreactive trypsin as part of neonatal screening are also considered. The data of a retrospective analysis of the case histories of patients with hypertrypsinogenemia are presented.
Южные алтайцы: различия в структуре генофонда теленгитов и алтай-кижи по данным X-STR маркеров
Authors: Вагайцева К.В. , Валихова Л.В. , Колесников Н.А. , Харьков В.Н. , Бочарова А.В. , Волкова И.А. , Степанов В.А.
Published: October 2024

В кратком сообщении представлены результаты анализа генетического разнообразия и структуры неравновесия по сцеплению в двух популяциях южных алтайцев: теленгитов и алтай-кижи. Анализ проводился с использованием мультиплексного набора TYPER X-19, включающего 18 STR-маркеров, локализованных на X-хромосоме. Продемонстрирована специфичность генетической структуры двух этносов, Выявлены различия в структуре неравновесия по сцеплению. Проведена оценка уровня исключающей способности 18 X-STR для ДНК-идентификации.

The brief report presents the results of the analysis of genetic diversity and the structure of linkage disequilibrium in two populations of southern Altaians: Telengites and Altai-Kizhi. The analysis was performed using the TYPER X-19 multiplex set, which includes 18 STR markers localized on the X chromosome. The specificity of the genetic structure of the two ethnic groups is demonstrated, and differences in the structure of linkage disequilibrium are revealed. The assessment of the level of identification informativeness of 18 X-STR for DNA identification was carried out.
Разработка интеллектуальных моделей проактивной защиты критической инфраструктуры финансового сектора на примере информационного обеспечения контрактных систем
Authors: Корчагин С.А. , Рубцов Д.Ю. , Беспалова Н.В. , Сердечный Д.В.
Published: October 2024

В работе предлагается подход к разработке интеллектуальных моделей проактивной защиты, ориентированный на информационное обеспечение контрактных систем в финансовом секторе. Представлена методология разработки интеллектуальных моделей, включающая в себя компоненты мониторинга, прогнозирования и предупреждения кибератак. Предложенная методология легла в основу практической реализации на языке Python с использованием библиотек Numpy и Scirket Learn. Особое внимание уделяется использованию передовых алгоритмов машинного обучения и искусственного интеллекта для выявления и предотвращения потенциальных угроз в режиме реального времени. В качестве практического примера рассматривается применение разработанных интеллектуальных моделей для защиты информационного обеспечения контрактных систем, используемых в финансовом секторе. Анализируются ключевые уязвимости, потенциальные атаки и методы их упреждающего обнаружения и блокирования. Результаты исследования подтверждаются данными вычислительного эксперимента и демонстрируют высокую эффективность предлагаемого подхода в повышении устойчивости критической информационной инфраструктуры финансового сектора к кибератакам. Внедрение интеллектуальных моделей проактивной защиты позволяет значительно снизить риски нарушения целостности и доступности ключевых данных, минимизировать финансовые и репутационные потери, а также прогнозировать и предупреждать потенциальные угрозы.

The paper proposes an approach to developing intelligent models of proactive protection focused on information support of contract systems in the financial sector. A methodology for developing intelligent models is presented, which includes components for monitoring, forecasting and preventing cyberattacks. The proposed methodology formed the basis for practical implementation in Python using the Numpy and Scirket Learn libraries. Particular attention is paid to the use of advanced machine learning and artificial intelligence algorithms to identify and prevent potential threats in real time. As a practical example, the application of the developed intelligent models to protect the information support of contract systems used in the financial sector is considered. Key vulnerabilities, potential attacks and methods for their proactive detection and blocking are analyzed. The results of the study are confirmed by the data of a computational experiment and demonstrate the high efficiency of the proposed approach in increasing the resilience of the critical information infrastructure of the financial sector to cyberattacks. The implementation of intelligent models of proactive protection allows us to significantly reduce the risks of compromising the integrity and availability of key data, minimize financial and reputational losses, and predict and prevent potential threats.
Imaging of Ovarian Metastases (OM) from Breast Cancer: A Review
Authors:   Radiologist Independent Researcher, Costa Contina Street 19 Zip Code 66054, Vasto, Italy, Donatello Diana
Published: October 2024

The ovary is a common site of metastases from other primary malignancies, and 5-30% of ovarian cancers are metastatic malignancies [1-16]. The most common primary origins are the breast, colon, and stomach[24]. Although imaging cannot always differentiate between secondary and primary ovarian neoplasms, and pathologic confirmation is generally required, it is important to recognize suggestive imaging features on pelvic US, CT and MR imaging [5,8-10,16,18-20]. OM from breast cancers is frequently asymptomatic until the masses have grown to certain size, and the metastatic tumors are frequently manifested as bilateral, solid, hypervascular, small ovarian masses [2]. Even though the Immunohistochemistry plays a key role in distinguishing between primary ovarian tumors and OM, and it was also important for confirming the metastatic nature of the ovarian lesion and diagnosing the primary tumor, imaging is vital to guide radiologists to include metastases in their differential diagnosis for atypical adnexal masses and in some cases avoid unnecessarie mutilative surgery [2-24]. In this review i will analize the main radiology features of OM from breast cancer to direct the surgery planning including referral practice, selection of candidates for primary chemotherapy by demonstration of non resectable disease, and tissue sampling in case of peritoneal carcinomatosis.
Non-Invasive Ventilation for Children Affected by Duchenne Muscular Dystrophy in Ukraine
Authors:   Mobile Ambulatory Brigade of Palliative Care for children, Kyiv, Ukraine, Trofimov Igor , Morozova Maryana ,   Intensive Care Unit, National Children’s Specialized Hospital Ohmatdyt, Kyiv, Ukraine, Shevchenko Roman ,   Department of Comprehensive Neuromonitoring with Pediatric Sleep Laboratory, National Children’s Specialized Hospital Ohmatdyt, Kyiv, Ukraine, Yashchenko Marharyta ,   NGO Duchenne Ukraine, Kropyvnytskyi, Ukraine, Toussaint Michel ,   Centre de Référence Neuromusculaire, Department of Neurology, Cliniques Universitaires de Bruxelles, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium
Published: October 2024

Background: Duchenne Muscular Dystrophy (DMD) poses significant challenges, especially in Low- and Middle-Income Countries (LMIC) with limited access to Non-Invasive Mechanical Ventilation (NIV), which prolongs life expectancy. Two years after Stage 1 of the successfull “1500 years of survival” NIV programme commenced with 8 DMD boys in Ukraine in 2021, this study further explores the Stage 2 of the programme in 2023. Method: DMD patients underwent a 5-day training program at the National Children’s Clinical Hospital “Okhmatdyt” in Kyiv, Ukraine, utilizing donated second-hand bilevel intermittent positive presure ventilators. Indications for NIV included: sleep-related symptoms, high Apnea-Hypopnea Index (AHI>10 events/hour), decreased Forced Vital Capacity (FVC=50%), low minimum saturation during sleep (SpO2<88%), or age above 17 years. Parallel Masterclass on NIV was conducted for Ukrainian healthcare professionals and patients’ parents. Findings: Thirteen DMD inpatients, aged (mean ± standard deviation) 14.8±2.6 years and FVC of 1.8±0.4L (65.5±22.8% predicted value) were enrolled. Criteria for NIV initiation were: age>17 years (n: 4), FVC% =50% (n :6), AHI>10 (n :2) and SpO2<88% (n :5). Follow-up phone calls were conducted to monitor progress. Three months post-hospitalization, all 13 patients consistently adhered to nocturnal ventilator treatment with a mean use of 7.5 hours per night. Conclusions: Despite the lack of equipment and system of reimbursement, the implementation of the comprehensive Stage 2 training programme supplying NIV for DMD patients in an LMIC such as in Ukraine, was a successful experience. The next steps in the home NIV programme will take place in the coming years.
Melt electrowriting of amorphous solid dispersions: influence of drug and plasticizer on rheology and printing performance
Authors: Keßler Larissa , Luxenhofer Robert
Published: October 2024

Drug loaded microfiber scaffolds have potential for sublingual drug delivery due to their fast dissolution time and tunable porosity. Such microfiber scaffolds can be prepared by melt electrowriting (MEW), wherein a polymer melt is electrostatically drawn out of a syringe onto a computer controlled moving collector. The fabrication of such scaffolds via MEW has previously been shown for a polymer with a glass transition temperature (Tg) just above room temperature, making handling challenging. For this reason, ABA triblock copolymers bearing poly(2-oxazoline) and poly(2-oxazine) with slightly higher Tg were synthesized and their processability into drug loaded microfiber scaffolds was assessed. Additionally, plasticizers commonly used in drug products were added to decrease the fabrication temperature. The aim was to investigate the influence of plasticizers on the melt viscosity and printability to expand the polymer platform for the preparation of drug loaded microfiber scaffolds. Temperature dependent melt rheology measurements of the polymers and their mixtures revealed a drop in viscosity by one order of magnitude by the addition of triethyl citrate and ethylene glycol, respectively. Addition of the model drug indomethacin led to a further decrease in viscosity. Even though the drug loaded samples were printable with and without the addition of triethyl citrate, better fiber stacking and therefore improved printing results were obtained with the plasticizer added. However, the addition of the plasticizer did alter the dissolution profile for some of the polymer samples, leading to longer dissolution times or lower drug release compared to the samples without plasticizer, which makes it difficult to predict the influence of the plasticizer on the dissolution profile.
Identification of novel PAD4 inhibitors using pharmacophore-based virtual screening, molecular docking, and molecular dynamics simulations
Authors: Mulosmani Trashgim , Malik Vivek
Published: October 2024

Protein arginine deiminase 4 (PAD4) is a member of the PAD family of enzymes which catalyze citrullination, or the conversion of the amino acid arginine to citrulline. Overexpression and dysregulation of PAD4 is implicated in the onset and progression of a variety of autoimmune and inflammatory diseases, including rheumatoid arthritis (RA). Thus, PAD4 inhibition via small molecules is an attractive therapeutic avenue. We utilized pharmacophore-based virtual screening of databases including over 120 million commercially available compounds to identify novel small molecule reversible inhibitors of PAD4. Molecular docking and ADME filtering identified our top three compounds that showed high binding affinity and promising ADME/Tox properties. Molecular dynamics (MD) simulations and post-MD analysis metrics such as RMSD, RMSF and Rg were carried out on the final hits to determine the stability of the complexes. All final hits outperform previously discovered reversible PAD4 inhibitors by docking score and ADME properties. Ultimately, MolPort 010-719-973 showed the most promising docking scores, residue interactions, stability, and binding energy as compared to the reference compound. Thus, we identify a novel reversible PAD4 inhibitor that may prove useful for the treatment of RA and can be used as a scaffold to design more potent PAD4 inhibitors.
Bridging the scales within transport-coupled kinetic models for heterogeneous electrocatalysis
Authors: Pillai Hemanth S. , Heenen Hendrik H. , Reuter Karsten , Bukas Vanessa J.
Published: October 2024

Optimizing reaction rates in heterogeneous electrocatalysis requires a solid, fundamental understanding of the interplay between mass transport and the intrinsic reaction kinetics at the electrode surface. As these processes occur on disparate scales, however, bridging the two into a (single) comprehensive reaction model is a challenging task and active area of research. In this perspective, we give a current overview of transport-coupled kinetic models while making a distinction between those that describe the surface reaction via an effective phenomenological or first-principles based kinetic model. This choice tends to be accompanied by a correspondingly more or less elaborate inclusion of mass transport. The two modeling approaches thus generally differ in the scientific questions that they aim to answer; whether focusing on elaborate transport effects and resulting design rules at the device level or more detailed mechanistic insight on a microscopic scale. We first discuss these approaches separately, including their pros and cons through notable studies in the existing literature, and conclude with an outlook view on combining the value of both in future research.
Pressure-Dependent Kinetic Analysis of the N2H3 Potential Energy Surface
Authors: Keslin Michal , Kaplan Kfir , Grinberg Dana Alon
Published: October 2024

Pressure-dependent reactions on the N2H3 potential energy surface (PES) are studied at the CCSDT(Q)/aug-cc-pVTZ//B2PLYPD3/aug-cc-pVTZ level of theory. This work extends the N2H3 PES relative to previous literature studies by adding another isomer, NH3N, and additional bimolecular channels adjacent to the new isomer, NNH + H2, and H2NN + H. Theoretical predictions are made for the rate coefficients of all path and well-skipping pressure-dependent reactions. The theoretical analyses employ a combination of ab-initio transition state theory and master equation simulations. Pressure-dependent rate coefficients are computed for all reactions in the network. The dominant products of NH2+NH(T) recombination are N2H2+H, and at high pressures and low temperatures N2H3 formation becomes important. Collisions of H2NN + H on this surface yield mainly N2H2 +H as well. Important secondary reactions are H2NN+ H <=> NNH + H2 at high temperatures and all examined pressures and H2NN + H <=> N2H3 at low temperatures and high pressures. None of these three reactions were considered by previous NH3 oxidation models with pressure-dependent rate coefficients. The rate coefficients obtained here should be useful in modeling ammonia, hydrazine, and hydrazine derivatives in various combustion environments.
Amination of Alkylboronic Esters
Authors: Almutairi Norah , Elsharif Nada , Kamranifard Telma , Wang Junning , Partridge Benjamin
Published: October 2024

Alkylboronic esters are high value chemical building blocks which can be used to make complex, C-sp3 rich molecules. The ability to convert the C-B bond in a range of C-C and C-heteroatom bond-forming reactions, in addition to their broad functional group compatibility, gives alkylboronic esters significant synthetic utility. Methods to convert boronic esters into amines have particular interest, due to the wide prevalence of nitrogen-based functional groups in biologically active compounds, functional materials, and catalysts. In this review, we explore different methods for the amination of alkylboronic esters. These can be split into three distinct classes based on the mechanism of reaction: amination through 1,2-metallate rearrangement, amination using nucleophilic ‘ate’ complexes, and alkyl variants of the Chan-Lam reaction.
Does Experience Guide People to Rebuy? Brand Loyalty at Ice Cream Shops in Yogyakarta
Authors: Kurniadita Yuan Adelintang
Published: October 2024

Food tourism is a major attraction for tourists because it provides an unforgettable experience. Yogyakarta is a tourist destination that is increasingly in demand because of its contemporary culinary concept. This research aims to determine the phenomenon of the experience of visitors to ice cream shops in Yogyakarta in enjoying ice cream in a shop with a unique concept in a tropical atmosphere. The brand experience felt by the ice cream shop customers was tested for its influence on brand loyalty. The concept of brand trust is also tested as a mediator of the relationship between brand experience and brand loyalty based on the commitment-trust theory. The formation of brand loyalty through the concepts of experience and trust is closely related to long-term brand-customer relationship management. A total of 179 data were analyzed using the PLS-SEM method. The research results show that brand experience has a positive significant effect on brand loyalty. In an indirect relationship, brand trust partially mediates the relationship between brand experience and brand loyalty.
Descarbonización de la economía. Casos de éxito en diferentes sectores económicos orientados hacia la E2050
Authors: Monsalve Castillo Zulay , López Astudillo Andrés , Garzón Morales Daniela
Published: October 2024

Frente al cambio climático, los países han firmado convenios, permitiendo desarrollar compromisos frente a las emisiones de gases de efecto invernadero (GEI), los cuales representan una de las principales causas del calentamiento global y sus consecuencias adversas. La generación en exceso de dichos GEI han generado alteraciones en los patrones del clima, el incremento de la temperatura en las diferentes épocas del año, la variabilidad climática alterando los ciclos de las cosechas y un sensible reconocimiento de la elevación del nivel del mar afectando las zonas costeras, donde diferentes simuladores presentan pronósticos y escenarios preocupantes sobre el impacto que se generará sobre las poblaciones que viven al frente de dichas costas. Al evaluar las responsabilidades entre los gobiernos, los ciudadanos /consumidores y las empresas transformadoras de bienes y servicios, esta última variable, es decir las empresas de los diferentes sectores, son una de las principales generadoras de los GEI, cuyas acciones para evitar la generación de los mismos en los procesos de transformación, desempeñan un papel principal que al mitigarlos a través de programas de descarbonización, reducen los efectos negativos sobre la atmosfera y las consecuencias del cambio climático, permitiendo la preservación de los recursos naturales. El objetivo de esta investigación exploratoria, se orienta en poder conocer los planes de descarbonización que diferentes empresas reconocidas por ser líderes en el desarrollo de la sostenibilidad, de diferentes sectores económicos de Colombia, con el fin de poder identificar el grado de alineación de dichos planes con la Estrategia 2050 (E2050) y la Política 2169 establecidas por el Gobierno Colombiano declarados en los diferentes compromisos adquiridos para que en el año 2050, el país en su actividad económica, haya reducido el 50% de los GEI en sus actividades económicas. Las empresas abordadas a través de la metodología caso de estudio, fueron analizadas mediante la información secundaria identificada en los diferentes reportes de sostenibilidad, como también mediante entrevistas realizadas a los responsables de los planes de descarbonización a corto y mediano plazo, identificando con esto, el aporte que se da frente a la estrategia país 2050 (E2050).
THE REALITY OF DATE PRODUCTION IN ALGERIA AND ITS RELATIONSHIP WITH NATIONAL INCOME: AN ECONOMETRIC STUDY USING THE AUTOREGRESSIVE DISTRIBUTED LAG (ARDL) MODEL DURING THE PERIOD 2000-2019
Authors: Mokadem Leila , Hadjadj Mourad , Zergoune Mohamed
Published: October 2024

Objective: The objective of this study is to investigate the evolution of date production in Algeria and its impact on the country's national income (GDP) from 2000 to 2019. This research aims to analyze the short-term and long-term relationships between date production and national income, assessing the significance of agricultural policies in enhancing the productivity and economic contribution of the date sector. Ultimately, the study seeks to highlight the role of date production in diversifying Algeria's exports and contributing to sustainable economic growth.
 
Theoretical Framework: This study explores the relationship between date production and national income in Algeria, using agricultural productivity theory, endogenous growth theory, export diversification theory, and the ARDL model. It aims to understand the impact of agricultural policies, human capital investment, and export diversification on Algeria's date production, highlighting the potential for economic diversification.
 
Method: This study analyzes the relationship between date production and Algeria's GDP from 2000 to 2019, using the Autoregressive Distributed Lag (ARDL) model. Data sources include Algeria's GDP and date production data. The study uses unit root tests, bounds testing, and error correction models to estimate the relationship. Statistical software like EViews or R is used for analysis.
 
Results and Discussion: The study reveals a positive relationship between date production and national income in Algeria from 2000 to 2019. The data suggests that agricultural policies have led to an upward trajectory in date production, while GDP has grown significantly. The study also highlights the importance of date production in Algeria's economy, particularly in diversifying exports. The long-term relationship suggests sustained investment in date production will yield continued benefits for national income.
 
Research Implications: The study highlights the importance of supporting agricultural policies that enhance productivity in Algeria's date sector. It suggests broader export diversification strategies, infrastructure development, and economic development. Strengthening date production can create job opportunities, stimulate rural development, and contribute to food security. Future research should explore other agricultural products, climate change, and technological innovations to improve yields and sustainability in the sector.
 
Originality/Value: The study explores Algeria's date production and national income relationship, providing insights for policymakers to diversify the economy beyond hydrocarbons and foster sustainable growth.
Obituary: A life devoted to bee protection: the legacy of Pieter Oomen
Authors: Pistorius Jens , Steeger Thomas , Alix Anne , Thompson Helen , Smagghe Guy , Van der Steen Sjef , Kevan Peter
Published: October 2024

Dr. Pieter Oomen, born in 1946,  a prominent and inspirational scientist in many areas of the biosafety of pesticides, most notably ecotoxicology, regulatory, risk assessment and bioassays, passed away peacefully on 19th of January 2024. His efforts have had a great and long-lasting impact on bee risk assessment and have improved bee protection. While we will miss a very warm and brilliant person; his many contributions to science and our ability to detect and mitigate risks to the environment remain.