bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan Antara Kelekatan Orang Tua Dengan Kedisiplinan Siswa Di Mts Nurul Huda Sedati
Authors: Mursini Septian Dwi , Widyastuti Widyastuti
Published: December 2019

This research is a correlational quantitative method that is motivated by phenomena that seek to undiscipline in school environment. This study aims to determine whether there is a relationship between parents with discipline students in MTs Nurul Huda Sedati. Variables in this research is Parent attachment as independent variable (X) and Discipline as independent variable (Y). This research was conducted in MTs Nurul Huda Sedati covering class VII-IX with total sample of 221 students, taken using proporsionate stratified random sampling technique. Data collection in this research using psychological model that is Likert, that is IPPA scale (parent attachment) and disciplinary scale. Hypothesis in this research is there is positive relation between parent attachment with student discipline. Data analysis was done by statistical technique from Product Moment from Pearson using SPSS 18.0 for windows. The result of data analysis show open coefficient (rxy) = 0,285 with significance level 0.000 (less than 0,01) accepted hypothesis. The results showed there was a positive relationship between parents with discipline students in MTs Nurul Huda Sedati.
A Two-factor Model of Intra-industry Trade: A Demonstration of Robustness of Krugman’s (1980) Model
Authors: Duan Lianjie
Published: December 2019

Using Cobb-Douglas production function with increasing returns to scale, this paper presents an intra-industry trade model which contains two factors, capital and labor. Thus, this paper extends Krugman’s (1980) single-factor model to a two-factor model with the entry cost. Firstly, an equilibrium analysis of closed economy is carried out. After the condition of existence and uniqueness of equilibrium is obtained, the analytic solutions are given. Secondly, it provides an analysis on trade effects. The results show that, under setup of symmetry among firms, the intra-industry trade can only enable consumers to benefit from product diversification without making firms achieve economies of scale. Obviously, this conclusion is consistent with Krugman (1980), which thus indicates robustness of Krugman’s (1980) model.
Characteristics of a Campanian delta deposit controlled by alternating river floods and tides: the Loyd Sandstone, Rangely Anticline, Colorado, U.S.A.
Authors: Flaig Peter P. , Hasiotis Stephen T. , Prather Timothy J. , Burton Darrin
Published: December 2019

The Campanian Loyd Sandstone Member of the Mancos Shale (Loyd) along the Rangely Anticline, Piceance Basin, Colorado, contains a series of multi-meter-thick, heterolithic, coarsening-upward successions (CUSs) with internal clinoforms comprising low-angle-dipping (< 5°), parallel-laminated sandstone beds interbedded with bioturbated flaser-wavy-lenticular bedded sandstone and siltstone. Loyd clinoforms are delta foresets composed of prodelta and delta-front deposits, including mouthbars. Many CUSs exhibit scours filled with bioturbated sandstone, or interbedded bioturbated sandstone and siltstone or mudstone representing aggradational fill of subaqueous terminal distributary channels or the migration of mouthbars into channel scours. Mud drapes on sedimentary structures and mud rip-up clasts are extremely common. A high-abundance, high-diversity, trace-fossil assemblage includes vertical, 1–4-m-deep Ophiomorpha that may penetrate multiple bedsets of parallel-laminated sandstones and highly bioturbated finer-grained interbeds. Bioturbation increases sandstone content in finer-grained interbeds, and provides sandy conduits that increase connectivity between beds.

Although parallel-laminated sandstones volumetrically dominate Loyd delta clinoforms, they likely represent relatively short-term freshwater and sediment input during river flooding that produced delta-front turbidity currents. Interbedded finer-grained beds, mud-draped sedimentary structures, and the high-abundance, high-diversity trace-fossil assemblages record longer amounts of time during reduced fluvial discharge, tidal reworking of sediments, and intense bioturbation under marine salinities. Controls on the internal characteristics of the Loyd delta deposits include: 1) a high sediment influx into a relatively shallow marine basin protected from wave action during normal regression; 2) relatively short-duration, episodic freshwater and sediment discharge from distributaries that reduced salinities, deposited sand as turbidity currents, and promoted delta-front channelization; and 3) longer-duration periods of reduced discharge with deposition of finer-grained sediment, tidal reworking, and bioturbation of sediments under higher salinities. These controls combined to produce the heterolithic, highly bioturbated, river-flood delivered, and tidally modified clinoforms of the Loyd that differ from deposits typically considered to be classic examples of fluvial-flood-dominated or extensively tidally modified deltas.
Determinants of Dietary Diversity among Pregnant Women Attending Public Health Facilities in Hossana town,South Ethiopia
Authors: Kobiro Degefa Helamo , Delil Romedan , Tamiru Desalegn , Zinab Beakal
Published: December 2019

Background: Dietary diversity refers to increasing the consumption of a variety of foods across and within the food groups, adequate and diversified diets during pregnancy is essential for fetus health, body maintenance and enhancement of maternal health through protection of infectious and non-communicable diseases. Hence, this study was targets to assess dietary diversity and its determinants among pregnant women of public health facilities in Hossana town, south Ethiopia Methods: Facility based cross-sectional study was applied among selected 303 pregnant women in Hossana town from June 1 to July 15, 2018. Systematic random sampling procedure was employed to recruit study participants. Data were collected using an interviewer administered pretested semi-structured questionnaire, one week dietary consumption was used to compute women dietary diversity score. Descriptive statistics and multivariable logistic regression were done to isolate predictors of dietary diversity. Result: The prevalence of low, medium and high women’s dietary diversity was 9.2, 48.2 and 42.6% respectively. Educational status (AOR=2.1; 95%CI: 4.8, 15.2), monthly income (AOR=2.1; 95% CI: 4.8, 15.2), nutritional education (AOR=2.3; 95% CI: 1.2, 4.4) and frequency of eating (AOR=12.9; 95% CI: 3.1, 52) were meaningfully associated with women dietary diversity. Conclusions: In this study women educational status, monthly income, receiving nutritional education and frequency of eating were determinants of women dietary diversity. Efforts should be strengthened towards improving women educational level, delivery of nutritional education and enhance frequency of eating among pregnant women to advance dietary diversity. Keywords: Dietary diversity, Determinants, Pregnancy
Insecticide Resistance in Anopheles stephensi in Somali Region, Eastern Ethiopia
Authors: Yared Solomon , Gebressielasie Araya , Damodaran Lambodhar , Bonnell Victoria , Lopez Karen , Janies Daniel , Carter Tamar
Published: December 2019

Background: The movement of malaria vectors into new areas is a growing concern in the efforts to control malaria. The recent report of Anopheles stephensi in eastern Ethiopia has raised the necessity to understand the insecticide resistance status of the vector in the region to better inform vector-based interventions. The aim of this study was to evaluate insecticide resistance in An. stephensi in eastern Ethiopia using two approaches: 1) World Health Organization (WHO) bioassay tests in An. stephensi and 2) genetic analysis of insecticide resistance genes in An. stephensi in eastern Ethiopia. Methods: Mosquito larava and pupae were collected from Kebridehar. Insecticide susceptibility of An. stephensi was tested with malathion 5%, bendiocarb 0.1%, propoxur 0.1%, deltamethrin 0.05%, permethrin 0.75%, Pirimiphos-methyl 0.25% and DDT 4%, according to WHO standard protocols. Results: All An. stephensi samples were resistant to carbamates, with mortality rates 23% and 21% for bendiocarb and propoxur, respectively. Adult An. stephensi was also resistant to pyrethroid insecticides with mortality rates 67% for deltamethrin and 53% for permethrin. Resistance to DDT and malathion was detected in An. stephensi with mortality rates of 32% as well as An. stephensi was resistance to pirimiphos-methyl with mortality rates 14%. Analysis of the voltage gate sodium channel gene (vgsc) revealed the absence of kdr L1014 mutations. Conclusion: Overall, these findings support that An. stephensi is resistant to several classes of insecticides, most notably pyrethroids. However, the absence of the kdr L1014 gene may suggest non-target site resistance mechanisms. Continued to insecticide resistance surveillance should be carried out in the region to confirm the findings on An. stephensi in Ethiopia.
What information do people with cirrhosis and their family members want during out-patient appointments? A qualitative study exploring the perspectives of patients, close family member and liver health professionals.
Authors: Low Joseph T S , Davis Sarah , Wilson Jo , Greenslade Lynda , Clancy Jennifer-Louise , Carroll Cathy , Craig Rachel , Marshall Aileen , Thorburn Douglas , Stone Patrick
Published: December 2019

Background: Good communication between health professionals and patients is important in healthcare, but difficult to implement in practice. This is highlighted in care for people with cirrhosis where patients have little understanding about their disease and feel stigmatized when communicating with health professionals. No study has explored the conversation exchanges between health professionals and patients with cirrhosis. This paper reports on secondary data analysis to explore the contents of patient doctor communication in hepatology out-patient clinics. Methods: Semi-structured interviews and focus groups were conducted with 12 patients, 5 close family members and 14 liver health professionals, aimed at exploring aspects of the consultation: questions asked or not asked during the consultation, the ease of answering questions, understanding of information received, and their preparation for the consultation. All interviews were audio-taped and data analysed using framework analysis. Results: Questions discussed centred on test results, symptoms and their management. Patients and family members felt comfortable with asking health professionals questions, but wanted better information about prognosis, the effects of medication on their symptoms and the likelihood of further deterioration in their liver disease. Patients had difficulty in understanding information received as it was couched in technical terms. Emphasis in consultations focused on the physical aspect of patient care leaving little time to discuss the psychological impact of their disease. Some clinicians felt patients should ask questions about their future, particularly about advance care plans. Key barriers in asking questions included: a) limited time for out-patient appointments, b) expectation that only medical issues could be discussed, c) fear about giving ‘negative’ information to patients, d) memory issues resulting from hepatic encephalopathy. Conclusions: Health professionals should use simple language when providing patients and their families with explanations about liver disease, its physical and psychological impact and prognosis. Information sheets about these topics should be made available for patients to take home. Doctors should be willing to explore supportive care issues with patients or consider referring patients to another health care professional with more time and expertise to discuss specific issues. Further work needed to explore the interactions between these groups using observational methods.
miR-188 promotes Oxaliplatin resistances through targeting RASA1 in colon cancer cells
Authors: Zhu Xijia , Luo Xishun , Song Zhike , Jiang Shiyu , Long Xiangkai , Gao Xuanyuan , Xie Xinyang , Zheng Laijian , Wang Haipeng
Published: December 2019

Background: The chemoresistance of colon cancer cells limits the efficacy of chemotherapy. miR-188 has been shown to be down-regulated in various types of cancer. The aim of this study was to explore the molecular mechanism of miR-188 in drug resistant cancer cells. Materials and methods: we examined the effects of miR-188 on the sensitivity of colon cancer cells to oxaliplatin (OXA) by using SW480/OXA cell line. The target of miR-188 was determined by luciferase activity assay. The cell cycle distribution were detected by flow cytometry. The expression of p21, Hoechst 33342 staining and Annexin V assays were used to detect the cell apoptosis. Results: The expression of miR-188 was significantly increased in SW480/OXA cells compared with SW480 cells. By luciferase assay we found that miR‑188 miRNA binds to RASA1 (Ras GTPase-activating protein 1, also known as p120RasGAP), and overexpression of miR‑188 inhibited RASA1 expression by binding to the 3'-untranslated region of RASA1 mRNA. In addition, suppression of miR‑188 enhanced the chemosensitivity of the oxaliplatin-resistant colon cancer cells. Furthermore, suppression of RASA1 abrogated the increasement of cell apoptosis induced by miR-188 inhibitor, while, overexpression of RASA1 induced cell apoptosis in SW480/OXA cells. Our results suggested that miR-188 played chemoresistant role in colon cancer through regulating RASA1 expression. Conclusion: The findings of our study suggest that target miR-188 is capable of enhancing the chemosensitivity of colon cancer cells by promoting RASA1.
Treatment of limbal stem cell deficiency with autologous cultivated oral mucosal epithelial transplantation
Authors: jin yuqi , zhang huicheng , wang huimin , ye yufeng
Published: December 2019

Background: To evaluate the feasibility of autologous cultivated oral mucosal epithelial transplantation (COMET) for the treatment of limbal stem cell deficiency (LSCD).Methods: Seven eyes from seven different patients with monocular LSCD were included in this study. Autologous oral mucosal epithelial cells were fabricated on ex vivo using amniotic membranes as a substrate. Clinical efficacy was evaluated by the coefficient of best-corrected visual acuity (BCVA). Clinical formation of the conjunctiva and symblepharon was evaluated and graded on a scale from 0 to 3. Clinical safety was evaluated by the presence of persistent epithelial defects, infection, and ocular hypertension.Results: Autologous COMET was successfully performed in all seven patients. The mean follow-up period was 10.7 months, during which time the postoperative formation of the conjunctiva and symblepharon was inhibited. BCVA was improved more than two lines in six eyes (86%) during the follow-up period. Complete reepithelialization of the corneal surfaces occurred in all treated eyes. No persistent epithelial defects, corneal infection, or postoperative ocular hypertension were observed. Conclusions: Autologous COMET offers a viable and safe alternative for the reconstruction of a stable ocular surface and improves vision in patients with LSCD.
A New Choroidal Layer Segmentation Method Based on Graph Theory and Directional Curvelet Transform in OCT Images
Authors: Esmaeili Mahdad , Eghtedar Reza Alizadeh , Peyman Alireza , Akhlaghi Mohammadreza , Rasta Seyed Hossein
Published: December 2019

Background: Automatic segmentation of the choroid on Optical Coherence Tomography (OCT) images helps ophthalmologists in diagnosing eye pathologies. In nature, it is not as exhausting as manual segmentation and does not depend on human errors. In this study, sixty EDI-OCT (Enhanced Depth Imaging Optical Coherence Tomography) images of both normal and abnormal eyes gathered from Isfahan Feiz Medical Center were used. The data were manually segmented by a retinal ophthalmologist to draw comparison with the proposed automatic segmentation technique.Methods: In this study, curvelet transform based KSVD dictionary learning and Lucy-Richardson algorithm was used to remove speckle noise from OCT images. The Outer / Inner Choroidal Boundaries (O/ICB) were determined utilizing graph theory. The area between ICB and OCB was considered as choroidal region.Results: The method was evaluated on the EDI-OCT images and the average Dice Similarity Coefficient (DSC) was calculated to be 92.14% ± 3.30% between automatic and manual segmented regions. Moreover, by applying the latest presented open-source algorithm by Mazzaferri et al on our dataset the mean DSC was calculated to be 55.75% ± 14.54%. Conclusions: A significant similarity was observed between automatic and manual segmentations, in both normal and abnormal eyes. Automatic segmentation of the choroidal layer could be also utilized in large-scale quantitative studies of the choroid.
Accuracy of intraocular lens power calculation using Scheimpflug tomography and OKULIX ray tracing software in corneal scarring
Authors: Nabil Karim Mahmoud
Published: December 2019

Background: To evaluate the accuracy of intraocular lens power (IOL) calculation using Scheimpflug tomography and OKULIX ray tracing software in corneal scarring. Methods: This study was conducted on 40 consecutive eyes, 20 cases with corneal scarring and coexisting cataract, and 20 controls with clear cornea, which underwent uneventful phacoemulsification and IOL implantation following Scheimpflug tomography and OKULIX ray tracing software and third generation IOL power calculation formulas for IOL power calculation. Accuracy of IOL power calculation was evaluated by subtracting expected and achieved spherical refraction 3 months postoperatively and was recorded as mean absolute error (MAE). Distance uncorrected visual acuity (UCVA) for each eye was measured using Snellen chart preoperatively and 3 months postoperatively; visual acuity was scored and converted to the logarithm of the minimum angle of resolution (LogMar). Results: In cases of corneal scarring, 20 eyes (100 %) yielded a postoperative spherical refraction which differed less than 1 diopter (D) from predicted, in 16 eyes (80 %) the postoperative spherical refraction was within 0.50 D from expected. The MAE was 0.2 D in cases, which did not differ significantly compared to controls (MAE 0.1 D). In corneal scarring cases, distance UCVA showed significant improvement from 1.3 Log Mar (Snellen equivalent 20/400) preoperatively to 0.5 Log Mar (Snellen equivalent 20/60) 3 months postoperatively. Conclusion: Scheimpflug tomography combined with OKULIX ray tracing software for calculation of IOL power provides accurate results in cases of corneal scarring.
Association between Muscular Strength and Depressive Symptoms among Chinese Nursing Freshmen—A Cross-Sectional Study
Authors: Ren Zhongyu , Guo Liya , Cao Jianhua , Li Yingke , Yang Guang , Cheng Peng , Liu Bin , Hao Zongji , Yao Hui , Shi Dongzhe , Chen Chang , Peng Li
Published: December 2019

Increased physical activity level is related to lower risk of depressive symptoms, and an inverse association between muscular strength and risk of depressive symptoms among the elderly population. However, the association among younger adults is unclear. The aim of this study was to examine the association between muscle strength, using handgrip strength as a representative of skeletal muscle strength, and the risk of depressive symptoms among Chinese female college freshman. A cross-sectional study was conducted among 867 participants aged between 16-23 years. Handgrip strength was measured with a handheld digital Smedley dynamometer, and depressive symptoms were evaluated using the 20-item Zung self-rating depression scale (SDS) with 3 cut-off points to indicate elevated depressive symptoms. We found that 10.7% of participants (17.2% or 29.2%) were classified as having moderate to severe depressive symptoms using 50 as the cut-off point. After adjusting for these potential confounders, the adjusted odds ratios for moderate-to-severe depressive symptoms across tertile of relative handgrip strength were 1.00 (reference) for tertile 1, 0.61 (95% CI: 0.35, 1.04) for tertile 2, and 0.53 (95% CI: 0.39, 0.94) for tertile 3 (P for trend: 0.024). The significant associations remained when other cut-off points (SDS 48 or 45) were used. Interactions between the handgrip strength and potential confounders for depressive symptoms in the final models were insignificant. This study showed that handgrip strength is inversely and independently related to the risk of depressive symptoms among Chinese female college freshman. These results can help with the development of an effective intervention strategy against depression. For future research, it is important to explore the causality of the effects of handgrip strength on the depressive symptoms by intervention study.
Unraveling the genetic basis of drought tolerance in potato
Authors: Tessema Biructawit Bekele , Gebregiorgis Gebremedhin , Visser Richard , Linden C. Gerard van der
Published: December 2019

Background: Potato is highly valued as a food security crop but is sensitive to drought stress. A relatively small reduction of the optimum amount of water can already result in a significant reduction in tuber yield. Therefore, unravelling the genetic basis of drought tolerance is important in order to enhance tolerance to drought in potato. We have evaluated a diploid potato backcross mapping population for drought tolerance under field conditions. Water application was withheld at the stage of tuber initiation. At the end of the drought stress period, we collected data on a number of morphological and physiological traits.Results: The potato population showed significant reduction in several growth traits measured, as well as in tuber yield. We applied quantitative trait locus (QTL) analysis to find genomic regions underlying these drought tolerance traits. We found 60 QTL for several of the traits measured under well-watered and drought stress conditions. From the total number of QTLs identified, 21 were detected under water stress conditions while 39 QTLs were identified under well-watered conditions. Drought specific QTLs for tuber fresh yield was detected on chromosome 7, 9 and 12.Conclusions: There is genetic variation in potato for drought tolerance and QTLs discovered for drought tolerance traits in this study can aid in improving potato for drought tolerance.
Influential Factors of Green Consciousness in Bangladesh: A Pragmatic Study on General Public in Dhaka City
Authors: Alam Jahangir , Rashid Bazlur
Published: December 2019

Green is the buzz term in the globe. Green is a crucial term that can mean a wide diversity of things to different people. Ecological approach is a current information that can be applied to everywhere. Bangladeshi general public must adopt ecologically sound behavior to keep up the clean environment. By location, Bangladesh falls in the coastal region. Bangladesh is going to be worst sufferers due to the effect of quick climate change throughout the globe. Bangladesh is an emerging and densely populated country in South Asia.

This research has been conducted with an objective to analyze the influential factors of green consciousness in Bangladesh: A pragmatic study on general public in Dhaka city. Different facets is important tools to guide the general public green consciousness in Bangladesh. This survey studies Environmental concern (EC), Environmental knowledge (EK), Social media (SM), Promotional tools (PT), Reference groups (RG), Government initiative (GI) influence on Public Green Consciousness (PGC). By using convenient sampling method, the data has been collected from 400 respondents. Data are analyzed using frequency, mean, standard deviation, correlation analysis, and regression analysis. From the descriptive statistics analysis, Environmental Concern (EC), Reference Groups (RG) and Government Initiative (GI) become the famous factors in general public green consciousness in Bangladesh. Likewise, from the results of regression analysis, the research is found that Social media (SM), Promotional tools (PT), Reference groups (RG), and Government initiative (GI) as the important factors, which significantly effects on Public Green Consciousness (PGC). The consequences of this study can be beneficial for both investigators and specialists. For examiners’, it provides guidelines for thoughtful consciousness designs, level, and their virtual status. Furthermore, this study proposals real-world direction and pertinent suggestions to the general public and ecological experts to inspire the strategies for improving green consciousness as ecological subjects are opportunities to create demand in greening firms.
Keywords: green consciousness, general public, influential factors, Dhaka city.
Simultaneous nitrification and denitrification (SND) bioaugmentation with Pseudomonas sp. HJ3 inoculated for enhancing phenol and nitrogen removal in coal gasification wastewater
Authors: Ma Weiwei , Han Yuxing , Ma Wencheng , Han Hongjun , Xu Chunyan , Zhu Hao
Published: December 2019

A simultaneous nitrification and denitrification (SND) bioaugmention system with Pseudomonas sp. HJ3 inoculated was established to explore the potential of simultaneous phenol and nitrogen removal in coal gasification wastewater (CGW). When the concentration of influent chemical oxygen demand (COD) and total phenols (TPh) was 1,765.94 ± 27.43 mg/L and 289.55 ± 10.32 mg/L, the average removal efficiency of COD and TPh at the stable operating stage reached 64.07% ± 0.76% and 74.91% ± 0.33%, respectively. Meanwhile, the average removal efficiency of NH4+-N and total nitrogen (TN) reached 67.96% ± 0.17% and 57.95% ± 0.12%, respectively. The maximum SND efficiency reached 83.51%. Furthermore, SND bioaugmentation performed with good nitrification tolerance of phenol shock load and significantly reduced toxic inhibition of organisms. Additionally, the microbial community analysis indicated that Pseudomonas sp. HJ3 was the predominant bacterium in the SND bioaugmentation system. Moreover, the indigenous nitrogen removal bacteria such as Thauera, Acidovorax and Stenotrophomonas were enriched, which further enhanced the nitrogen removal in the SND bioaugmentation system. The results demonstrated the promising application of SND bioaugmentation for enhancing simultaneous phenol and nitrogen removal in CGW treatment.
Особенности идентичности женщин в кризисные и межкризисные возрастные периоды
Authors: Кузьмин Михаил Ю. , Миронова Елена И. , Осипенок Оксана А.
Published: December 2019

Introduction. This paper examines the characteristics of identities in women of various ages and ethnic groups in crisis and inter-crisis age periods. The novelty of the research lies in studying the identities of women of Russian, Buryat, and mixed ethnic groups in crisis periods regardless of their age.

Methods. The study used the following techniques: (a) the Twenty Statements Test developed by M. Kuhn and T. MacPartland, (b) the Life Line technique developed by A. Kronik, and (c) the SEI test by developed E. L. Soldatova.

Results. Regardless of the periodization of crisis and inter-crisis periods in adulthood, the level of achieved identity is higher in the crisis periods. Meanwhile, the level of diffused identity is higher in the inter-crisis periods. Differences in identity statuses are mainly inherent to women of Russian ethnic group. The SEI test results showed no significant differences in women identifying themselves with Buryat ethnic group or those of the mixed ethnic group. Certain age periods are characterized by greatest differences in identity statuses. Differences in the achieved identity statuses refer to the period between the 35th and 46th year of age. Women older than 46 years of age demonstrate differences in the diffused identity statuses. During inter-crisis periods, women represent a great number of events that may happen to them in the future, as well as in the period of life that they subjectively refer to the future. During crisis periods, women with the status of achieved identity are characterized by a more detailed representation of their future. During crisis periods, women of Russian ethnic group plan their future in terms of their unique identities. Women of Buryat ethnic group plan their future being guided by social roles attributed to them.

Discussion. The empirical results obtained in this study are compared to those from previous studies in this field. The differences in the results are analyzed in terms of differences in the study samples, cultural aspects, and approaches to studying identity development.
Трехкомпонентная модель злоупотребления в межличностной коммуникации
Authors: Чуганский Сергей А.
Published: December 2019

Introduction. One of the most relevant issues in practical psychology is the topic of abuse – manipulation, violence, and violation of personal boundaries of any kind. The purpose of this study is to provide a concise, structured view of communication abuse, expressed in a three-component model. The communication of abuse contains three components: asymmetry, variability, and purpose. The following hypotheses were verified: 1) the detection of abuse by the person in situations of interpersonal communication occurs with the simultaneous presence of all three components; 2) abuse communication can be identified more frequently (successfully) in case of a higher level of psychological competence.

Methods. To verify the hypotheses of the study, we created a questionnaire entitled Experimental Test for the Detection of Abuse. The sample of the study was comprised of 74 respondents aged 20 to 58 years, 34 of whom were professional psychologists (the group of ‘psychologists’) and 40 of whom were specialists of other professions (the group of ‘non-psychologists’). The gender composition was as follows: 24 males and 50 females.

Results. The hypotheses verification showed the following results: 1) the empirical distribution of answers for the whole sample, as well as for the “psychologists” and “non-psychologists”, does not differ from the theoretical one; 2) the results for the group of “psychologists” are significantly different from those obtained in the group of “non-psychologists”.

Discussion. Both hypotheses of the study were confirmed: 1) the detection of abuse takes place in accordance with the proposed three-component abuse model; 2) psychological competence and other kinds of psychological activities reliably contribute to a more successful recognition of abuse.

Conclusion. In the article we formulated the conclusions about the correctness of the three-component abuse model and the influence of the level of psychological competence on the ability to determine abuse in social contacts. The presented model may become a method of analyzing communications of abuse and be used to correct them.
Preparation of Palladium(II) Complexes of 1-substituted-3-phospholene Ligands and their Evaluation as Catalysts in Hydroalkoxycarbonylation
Authors: Bagi Péter , Herbay Réka , Györke Gábor , Pongrácz Péter , Kollár László , Timári István , Drahos László , Keglevich György
Published: December 2019

:

A series of palladium(II) complexes incorporating 1-substituted-3-methyl-3-
phospholenes as the P-ligands were prepared from phospholene oxides by deoxygenation
followed by complexation with PdCl2(PhCN)2. The two 1-substituted-3-methyl-3-
phospholene ligands were trans position to each other in the Pd(II)-complexes. As the
ligands contain a P-stereogenic center, the Pd-complexes were obtained as a 1:1 mixture
of two stereoisomers, the homochiral (R,R and S,S) and the meso (R,S) forms, when racemic
starting materials were used. An optically active Pd-complex containing (R)-1-propyl-
3-phospholene ligand was also prepared. Catalytic activity of an aryl- and an alkyl-3-
phospholene-palladium(II)-complex was evaluated in hydroalkoxycarbonylation of
styrene. The alkyl-derivative showed higher activity and selectivity towards the formation
of the esters of 3-phenylpropionic acid. However, the overall activity of these PdCl2(phospholene)2-type
complexes was low.
Inorganic Gold and Polymeric Poly(Lactide-co-glycolide) Nanoparticles as Novel Strategies to Ameliorate the Biological Properties of Antimicrobial Peptides
Authors: Casciaro Bruno , Ghirga Francesca , Quaglio Deborah , Mangoni Maria Luisa
Published: December 2019

Cationic antimicrobial peptides (AMPs) are an interesting class of gene-encoded molecules
endowed with a broad-spectrum of anti-infective activity and immunomodulatory properties. They
represent promising candidates for the development of new antibiotics, mainly due to their membraneperturbing
mechanism of action that very rarely induces microbial resistance. However, bringing
AMPs into the clinical field is hampered by some intrinsic limitations, encompassing low peptide
bioavailability at the target site and high peptide susceptibility to proteolytic degradation. In this regard,
nanotechnologies represent an innovative strategy to circumvent these issues. According to the
literature, a large variety of nanoparticulate systems have been employed for drug-delivery, bioimaging,
biosensors or nanoantibiotics. The possibility of conjugating different types of molecules, including
AMPs, to these systems, allows the production of nanoformulations able to enhance the biological
profile of the compound while reducing its cytotoxicity and prolonging its residence time. In this minireview,
inorganic gold nanoparticles (NPs) and biodegradable polymeric NPs made of poly(lactide-coglycolide)
are described with particular emphasis on examples of the conjugation of AMPs to them, to
highlight the great potential of such nanoformulations as alternative antimicrobials.
RPS24c Isoform Facilitates Tumor Angiogenesis Via Promoting the Stability of MVIH in Colorectal Cancer
Authors: Wang Yue , Wu Youjun , Xiao Kun , Zhao Yingjie , Lv Gang , Xu Shiyan , Wu Fuquan
Published: December 2019

Background:

Colorectal cancer (CRC) is the second leading cause of death
worldwide, and distant metastasis is responsible for the poor prognosis in patients with
advanced-stage CRC. RPS24 (ribosomal protein S24) as a ribosomal protein, multiple
transcript variant encoding different isoforms have been found for this gene. Our
previous studies have demonstrated that RPS24 is overexpressed in CRC. However,
the mechanisms underlying the role of RPS24 in tumor development have not been fully
defined.

Methods:

Expression of RPS24 isoforms and lncRNA MVIH in CRC tissues and cell
lines were quantified by real-time PCR or western blotting assay. Endothelial tube
formation assay was performed to determine the effect of RPS24 on tumor
angiogenesis. The cell viability of HUVEC was determined by MTT assay, and the
migration and invasion ability of HUVEC were detected by transwell assay. PGK1
secretion was tested with a specific ELISA kit.

Results:

Here, we found that RPS24c isoform was a major contributor to tumor
angiogenesis, a vital process in tumor growth and metastasis. Real-time PCR revealed
that RPS24c isoform was highly expressed in CRC tissues, while other isoforms are
present in both normal and CRC tissues with no statistical difference. Moreover the
change of RPS24 protein level is mainly due to the fluctuation of RPS24c. Furthermore,
we observed that silencing RPS24c could decrease angiogenesis by inhibiting tubule
formation, HUVEC cell proliferation and migration. Additionally, we investigated the
molecular mechanisms and demonstrated that RPS24c mRNA interacted with lncRNA
MVIH, the binding-interaction enhanced the stability of each other, thereby activated
angiogenesis by inhibiting the secretion of PGK1.

Conclusion:

RPS24c facilitates tumor angiogenesis via the RPS24c/MVIH/PGK1
pathway in CRC. RPS24c inhibition may be a novel option for anti-vascular treatment in
CRC.
Discovery of 2-aminopyridine Derivatives with Antichagasic and Antileishmanial Activity Using Phenotypic Assays
Authors: Tezuka Daiane Yukie , de Albuquerque Sergio , Montanari Carlos Alberto , Leitão Andrei
Published: December 2019

Background:

Compounds previously studied as anticancer were screened against
trypomastigotes to access the bioactivity. The epimastigote form of Trypanosoma cruzi Y strain and
the promastigote form of Leishmania amazonensis and Leishmania infantum were used in this work.

Methods:

Cell-based assays were performed to access the bioactivity of the compounds using MTT
and the flow cytometry methods.

Results:

Neq0438, Neq0474 and Neq0440 had the highest potency, with EC50 of 39 μM (L.
amazonensis), 52 μM (T. cruzi) and 81 μM (T. cruzi), respectively. These molecules were inactive
for Balb/C fibroblast cell line at concentrations above 250 μM, showing selectivity for the parasites.

Conclusion:

This is the first report that demonstrates antiparasitic activity for the 2-aminopyridine
scaffold, with cross-activity against cancer cells.
Antibacterial Activity of Steroids Isolated from the Madagascar Marine Sponge Biemna laboutei: Δ7 Steroids as New Potential Agents Against Pathogenic Bacteria
Authors: Ralambondrahety Rahanira , Couzinet-Mossion Aurélie , Rabesaotra Vony , Andriambeloson Onja , Barnathan Gilles , Rakotovao Marcelle , Wielgosz-Collin Gaëtane
Published: December 2019

Background:

Nowadays, the efficiency of antibiotics is endangered by the development of
resistant bacterial strains. Consequently, novel bioactive agents are intensively searched. Marine sponges
are well-known for being major sources of bioactive compounds, including unusual sterols. Until
now, among sterols, noteworthy antibacterial activity has been reported exclusively for Δ5 sterols.

Objectives:

This study aims to describe the steroid composition of the marine sponge Biemna laboutei
collected in the North coast of Madagascar, and the antibacterial activity of steroid mixture
against human pathogenic strains.

Methods:

Sponge was extracted in CHCl3/MeOH. Free steroids were separated from other lipids by
column chromatography with dichloromethane as specific eluent. Free sterols/steroids and sterol
acetates were analysed by gas chromatography coupled with mass spectrometry. Antibacterial activity
of steroid fractions was assessed for eight strains using agar diffusion with cellulose disks.

Results:

Neutral lipids were the major lipid class (79.1% of total lipids). The dichloromethane eluted
fraction contained only free steroids giving rise to the identification of eleven compounds. These components
presented exclusively Δ7 unsaturation, including lathosterol as the major one (38.4%) and four
3-oxo-steroids (11.8%). The steroid fraction of B. laboutei has exhibited inhibitory activity against
pathogenic strains but more particularly against gram(+) Bacillus cereus (MIC of 12.5 μg/mL) and
Staphylococcus aureus (MIC of 25 μg/mL) strains. This latter bacterium causes several illnesses, some
of those strains being antibiotic-resistant and this becomes a worldwide health problem.

Conclusion:

This is the first report for an antibacterial activity of a mixture of Δ7 steroids against a
resistant strain of S. aureus to many antibiotics.
Design, Development and Optimization of Ramipril Solid Lipid Nanoparticles Using Solvent Emulsification and Evaporation Method
Authors: Vakhariya Rohan R. , Salunkhe Vijay R. , Randive Dheeraj S. , Bhutkar Mangesh A. , Bhinge Somnath D.
Published: December 2019

Background:

Ramipril, an antihypertensive drug exhibits 28% of oral bioavailability
and is also excreted out quickly through the kidneys. Moreover, numerous side effects of Ramipril
have been reported such as, hypotension (postural), increasing potassium level, and angioedema,
when it is presented as an immediate dosage form. Hence, to conquer the side-effects associated
with the drug and to increase its bioavailability, the present study was undertaken.

Objective:

The objective of the proposed approach was to design, develop and optimize Ramiprilloaded
solid lipid nanoparticles.

Methods:

Solvent emulsification and evaporation method were employed to prepare Ramiprilloaded
solid lipid nanoparticles containing stearic acid and phosphatidylcholine as a lipid and surfactant,
respectively. The prepared formulations were studied for particle size analysis, % entrapment
efficiency, Zeta Potential, SEM, X-ray diffraction study, FTIR, NMR spectroscopy, in vitro
release study and stability study.

Result:

The obtained results were noted to be within the standard limits. No interaction between
Ramipril and other excipients, was confirmed with the FT-IR study of the formulations. Particle
size analysis confirmed that the size of the prepared formulations ranged between 200-350 nm.
The percent entrapment efficiency was observed in the range of 70.61-91.60%. The result of entrapment
and particle size of the nanoparticles from the R5 batch was adjudged. The designed formulation
noted a 70.50% cumulative drug release within a period of 7 h. The designed batch
showed a mean zeta potential of -29.4 mV, exhibiting good stability of the formulation.

Conclusion:

The developed formulation was found to be stable and it represents a promising system
for the sustained and controlled delivery of Ramipril.
Pengaruh pemberian jus mentimun dan minuman isotonik terhadap tingkat dehidrasi pada latihan Zumba fitness
Authors: Pratama Rizki Yudha , Damayanti Imas , Ruhayati Yati
Published: December 2019

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus mentimun dan minuman isotonik terhadap tingkat dehidrasi. Metode yang digunakan yaitu dengan eksperimen dengan desain penelitian cross over design. 8 orang mahasiswa keperawatan UPI 2018 berpartisipasi sebagai sampel dalam penelitian ini. Dehydrating exercise test yang digunakan dalam penelitian ini adalah Zumba fitness selama 60 menit. Instrumen pengambilan data menggunakan Urine Refractometer Spesific Gravity dan 5 visual analog scale. Hasil dari penelitian ini menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara hasil pre-test dan post-test pada jus mentimun dan minuman isotonik terhadap tingkat dehidrasi sebesar p(0.83) dan p(1.52). Pada penilaian subjektif tidak terdapat perbedaan yang signifikan pada penilaian subjektif antara jus mentimun dan minuman isotonik dengan nilai signifikansi sebesar Thirst p(0.398), Bloatedness p(0.609), Refreshed p(0.758), Stomach upset p(0.486) dan Tiredness (0.683). Demikian pula tidak terdapat perbedaan yang signifikan antara jus mentimun dan minuman isotonik terhadap tingkat dehidrasi dengan taraf signifikansi sebesar p(0.696). Hal ini menunjukkan bahwa jus mentimun dapat mengurangi potensi terjadinya dehidrasi sama baiknya dengan minuman isotonik. Ini membuktikan bahwa jus mentimun dapat menggantikan minuman isotonik sebagai minuman olahraga. The effect of giving cucumber juice and isotonic drink of dehydration level on Zumba fitness exercise AbstractThis research is intended to know comparison the effect of giving cucumber juice and isotonic drink on level of dehydration. Method which is used is experiment with cross over design. 8 UPI 2018 nursing students participated as samples in this research. Dehydrating exercise test that used in this research is Zumba fitness for 60 minute. Instrument data retrieval uses Urine Refractometer Spesific Gravity dan 5 visual analog scale. The result of this research indicated that there’s no difference significantly between the results of pre-test and post-test on cucumber juice and isotonic drink to the level of dehydration p(0.83) and p(1.52). In subjective assessment there is no significant difference in the subjective assessment between cucumber juice and isotonic drink with a significance in the amount of Thirst p(0.398), Bloatedness p(0.609), Refreshed p(0.758), Stomach upset p(0.486) dan Tiredness p(0.683). As well as there is no significant difference between cucumber juice and isotonic drink to the level of dehydration with a significance level of p(0.696). This shows that cucumber juice can reduce the potential of dehydration as good as isotonic water. It proved that cucumber juice can replaced isotonic water as sport drink.
EFFECTIVENESS GUIDED INQUIRY LEARNING METHOD TOWARDS SCIENCE LEARNING OUTCOMES OF FOURTH GRADE HIGH ACHIEVING STUDENTS ON THEME 8 AT SD 1 TRIRENGGO
Authors: Kusuma Dewi Tri Avivah , Wahab Rochmat
Published: December 2019

This study attemps to know the effectiveness guided inquiry learning method  towards science learning outcomes of fourth grade high achieving students on theme 8 at SD 1 Trirenggo. The study use a kind of quasi experiment with a quantitative approch with one group pretest and posttest design. The subject were 4 high achieving students of fourth grade at SD 1 Trirenggo. The technique of data collection use a test, observation, and documentation. Data analysis in this study with quantitative decription statistic. The result of this study indicates the increased value posttest that having given guided inquiry learning method treatment. The result of each subject in increasing on the subject ALF increased of 65 be 80 with a good criteria, subjek FDL increased value of 55 be 75 with enough criteria, subjek MYL increased value of 75 be 85 with good criteria, and subject SFD increased value of 60 be 80 with good criteria. The increase shows that guided inquiry learning method effective againts the science learning outcomes of fourth grade high achieving students on theme 8 at SD 1 Trirenggo
The Dynamics of Special Interests Development in Autistic Student
Authors: Rini Thalia Ayu
Published: December 2019

The purpose of this case study was to describe the dynamics of special interests development in an autistic student at Dian Amanah Special School Yogyakarta. This study collected data about: 1) form of special interests; 2) model of interest’s development; 3) and consequence of special interests. Data were collected by observation, interview, and documentation technique. Data were analyzed data reduction, data display, and drawing conclusion/verification. The results showed 1) subject has 2 form of special interests on music and people; 2) special interests on music triggered by family and persisted by maintenance factor such as environmental opportunity, perception of ability, cognitive reward, and emotional reward while special interests on people triggered by other interests and persisted by maintenance factor such as environmental opportunity, cognitive reward, and emotional reward; 3) special interests on music viewed positively because there was perception of ability while SI on people viewed negatively due to behavioral problem.