bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulated Fermentation of Strong-Flavor Baijiu through Functional Microbial Combination to Realize the Stable Synthesis of Important Flavor Chemicals
Authors: Xu Youqiang , Wu Mengqin , Zhao Dong , Zheng Jia , Dai Mengqi , Li Xiuting , Li Weiwei , Zhang Chengnan , Sun Baoguo
Published: February 2023

The solid-state fermentation of Baijiu is complicated by the co-fermentation of many microorganisms. The instability of the composition and abundance of the microorganisms in the fermentation process leads to fluctuations of product quality, which is one of the bottleneck problems faced by the Strong-flavor Baijiu industry. In this study, we established a combination of functional microorganisms for the stable fermentation of the main flavor compounds of Baijiu, including medium and long-chain fatty acid ethyl esters such as hexanoic acid, ethyl ester; butanoic acid, ethyl ester; octanoic acid, ethyl ester; acetic acid, ethyl ester; 9,12-octadecadienoic acid, ethyl ester; and decanoic acid, ethyl ester in the fermented grains. Our study investigated the effects of microbial combinations on the fermentation from three aspects: microbial composition, microbial interactions, and microbial association with flavor compounds. The results showed that the added functional microorganisms (Lactobacillus, Clostridium, Caproiciproducens, Saccharomyces, and Aspergillus) became the dominant species in the fermentation system and formed positive interactions with other microorganisms, while the negative interactions between microorganisms were significantly reduced in the fermentation systems that contained both Daqu and functional microorganisms. The redundancy analysis showed that the functional microorganisms (Lactobacillus, Saccharomyces, Clostridium, Cloacibacterium, Chaenothecopsis, Anaerosporobacter, and Sporolactobacillus) showed strong positive correlations with the main flavor compounds (hexanoic acid, ethyl ester; lactic acid, ethyl ester; butanoic acid, ethyl ester; acetic acid, ethyl ester; and octanoic acid, ethyl ester). These results indicated that it was feasible to produce Baijiu with a functional microbial combination, and that this could promote stable Baijiu production.
Correction: Bertuso et al. Combining Celery Oleoresin, Limonene, and Rhamnolipid as a New Strategy to Control Endospore-Forming Bacillus cereus. Foods 2021, 10, 455
Authors: Bertuso Paula de Camargo , Mayer Débora M. Drappé , Nitschke Marcia
Published: February 2023

There was an error in the original publication [...]
The Potential Future of Insects in the European Food System: A Systematic Review Based on the Consumer Point of View
Authors: Mina Giorgio , Peira Giovanni , Bonadonna Alessandro
Published: February 2023

Edible insects recently gained attention as a potential contributor to the future sustainability of the food system. Insect farming has indeed shown to have environmental and nutritional benefits, but edible insects are still an unusual foodstuff in Europe. The purpose of this article is to analyze the barriers and drivers of insect consumption in Europe and to identify the most promising strategies to convince consumers to include insect-based products in their diets. To answer these research questions, a systematic review of the literature on the consumer’s point of view about insects as food was performed. The results show that the main barrier to the development of this market is related to the psychological rejection of consumers induced by disgust toward entomophagy. To break down these barriers, it is essential to increase the general knowledge about the environmental and nutritional benefits of entomophagy. Furthermore, the limited size of the edible insect market appears to be a structural barrier. Expanding the reach of the market and consumer familiarity with edible insects will increase their acceptability. Finally, some product-related strategies are also highlighted. Furthermore, this article brings new knowledge about the effectiveness of the environmental motive in convincing consumers to try edible insects.
Salmonella Risk Assessment in Poultry Meat from Farm to Consumer in Korea
Authors: Oh Hyemin , Yoon Yohan , Yoon Jang-Won , Oh Se-Wook , Lee Soomin , Lee Heeyoung
Published: February 2023

This study predicted Salmonella outbreak risk from eating cooked poultry in various methods. The incidence of Salmonella in poultry meat and the environment from farm to home for consumption was investigated. To develop the predictive models, Salmonella growth data were collected at 4–25 °C during storage and fitted with the Baranyi model. The effects of cooking on cell counts in poultry meat were investigated. Temperature, duration, and consumption patterns were all searched. A simulation in @Risk was run using these data to estimate the probability of foodborne Salmonella disease. In farm, Salmonella was detected from only fecal samples (8.5%; 56/660). In slaughterhouses, Salmonella was detected from feces 16.0% (38/237) for chicken and 19.5% (82/420) for duck) and from carcasses of each step (scalding, defeathering, and chilling) by cross contamination. In chicken (n = 270) and duck (n = 205), Salmonella was detected in 5 chicken (1.9%) and 16 duck meat samples (7.8%). Salmonella contamination levels were initially estimated to be −3.1 Log CFU/g and −2.5 Log CFU/g, respectively. With R2 values between 0.862 and 0.924, the predictive models were suitable for describing the fate of Salmonella in poultry meat with of 0.862 and 0.924. The Salmonella was not detected when poultry meat cooks completely. However, if poultry meat contaminated with Salmonella were cooked incompletely, Salmonella remained on the food surface. The risk of foodborne Salmonella disease from poultry consumption after cooking was 3.0 × 10−10/person/day and 8.8 × 10−11/person/day in South Korea, indicating a low risk.
Young Radio Sources Expanding in Gas-Rich ISM: Using Cold Molecular Gas to Trace Their Impact
Authors: Morganti Raffaella , Murthy Suma , Guillard Pierre , Oosterloo Tom , Garcia-Burillo Santiago
Published: February 2023

We present an overview of the results obtained from the study of the resolved distribution of molecular gas around eight young (≲106yr), peaked-spectrum radio galaxies. Tracing the distribution and kinematics of the gas around these radio sources allows us to trace the interplay between the jets and the surrounding medium. For three of these sources, we present new CO(1-0) observations, obtained with the Northern Extended Millimeter Array (NOEMA) with arcsecond resolution. In two of these targets, we also detected CN lines, both in emission and absorption. Combining the new observations with already published data, we discuss the main results obtained. Although we found that a large fraction of the cold molecular gas was distributed in disc-like rotating structures, in the vast majority of the sources, high turbulence and deviations from purely quiescent gas (including outflows) were observed in the region co-spatial with the radio continuum emission. This suggests the presence of an interaction between radio plasma and cold molecular gas. In particular, we found that newly born and young radio jets, even those with low power i.e., Pjet < 1045 erg s−1), are able to drive massive outflows of cold, molecular gas. The outflows are, however, limited to the sub-kpc regions and likely short lived. On larger scales (a few kpc), we observed cases where the molecular gas appears to avoid the radio lobes and, instead, wraps around them. The results suggest the presence of an evolutionary sequence, which is consistent with previous simulations, where the type of impact of the radio plasma changes as the jet expands, going from a direct jet-cloud interaction able to drive gas outflows on sub-kpc scales to a more gentle pushing aside of the gas, increasing its turbulence and likely limiting its cooling on kpc scales. This effect can be mediated by the cocoon of shocked gas inflated by the jet–cloud interactions. Building larger samples of young and evolved radio sources for observation at a similar depth and spatial resolution to test this scenario is now needed and may be possible thanks to more data becoming available in the growing public archives.
Prevalence of Potentially Inappropriate Prescriptions According to the New STOPP/START Criteria in Nursing Homes: A Systematic Review
Authors: Díaz Planelles Isabel , Navarro-Tapia Elisabet , García-Algar Óscar , Andreu-Fernández Vicente
Published: February 2023

The demand for long-term care is expected to increase due to the rising life expectancy and the increased prevalence of long-term illnesses. Nursing home residents are at an increased risk of suffering adverse drug events due to inadequate prescriptions. The main objective of this systematic review is to collect and analyze the prevalence of potentially inadequate prescriptions based on the new version of STOPP/START criteria in this specific population. Databases (PubMed, Web of Science and Cochrane) were searched for inappropriate prescription use in nursing homes according to the second version of STOPP/START criteria. The risk of bias was assessed with the STROBE checklist. A total of 35 articles were assessed for eligibility. One hundred and forty nursing homes and more than 6900 residents were evaluated through the analysis of 13 studies of the last eight years. The reviewed literature returned prevalence ranges between 67.8% and 87.7% according to the STOPP criteria, according to START criteria prevalence ranged from 39.5% to 99.7%. The main factors associated with the presence of inappropriate prescriptions were age, comorbidities, and polypharmacy. These data highlight that, although the STOPP/START criteria were initially developed for community-dwelling older adults, its use in nursing homes may be a starting point to help detect more efficiently inappropriate prescriptions in institutionalized patients. We hope that this review will help to draw attention to the need for medication monitoring systems in this vulnerable population.
Candida auris as an Emergent Public Health Problem: A Current Update on European Outbreaks and Cases
Authors: Geremia Nicholas , Brugnaro Pierluigi , Solinas Maria , Scarparo Claudio , Panese Sandro
Published: February 2023

Candida auris is considered to be an emerging fungal pathogen and is related to high mortality rates, persistent candidemia, inconsistencies in susceptibility testing results and misidentification by available commercial identification systems. Multidrug-resistant (MDR) and pandrug-resistant (PDR) strains are increasingly detected. In Europe, hospital outbreaks caused by C. auris have been reported in the United Kingdom (UK), Italy and Spain; however, several cases have been sporadically detected in all European countries. C. auris is difficult to control despite enhanced control measures due to its ability to survive for a long time in environments and colonize patients for prolonged periods. An adequate laboratory diagnostic capacity and national surveillance are fundamental to rapidly detect new C. auris cases and to apply the correct measures to circumscribe them and prevent their spread. Our narrative review aims to highlight the primary C. auris outbreaks and case reports that have occurred in Europe.
Development and Testing of an IoT Spectroscopic Nutrient Monitoring System for Use in Micro Indoor Smart Hydroponics
Authors: Stevens Joseph D , Murray David , Diepeveen Dean , Toohey Danny
Published: February 2023

Nutrient monitoring in Micro Indoor Smart Hydroponics (MISH) relies on measuring electrical conductivity or total dissolved solids to determine the amount of nutrients in a hydroponic solution. Neither method can distinguish concentrations of individual nutrients. This study presents the development and testing of a novel spectroscopic sensor system to monitor nitrogen changes in nutrient solutions for MISH systems. The design phase determined that using an inexpensive AS7265x Internet of Thing (IoT) sensor in a transflective spectroscopic application could effectively detect small fluctuations in nitrogen concentraation. Next, a novel transflective sensor apparatus was designed and constructed for use in a MISH system experiment, growing lettuce over 30 days. Two solution tanks of different sizes, 80 L and 40 L, were used in the deployment of the system. Samples from each tank were analyzed for nitrogen concentration in a laboratory, and multilinear regression was used to predict the nitrogen concentrations using the AS7265x 18 spectral channels recorded in the sensor system. Significant results were found for both tanks with an R2 of 0.904 and 0.911 for the 80 and 40 L tanks, respectively. However, while the use of all wavelengths produced an accurate model, none of the individual wavelengths were indicative on their own. These findings indicate that the novel system presented in this study successfully and accurately monitors changes in nitrogen concentrations for MISH systems, using low cost IoT sensors.
Cinnamom verum Plantations in the Lowland Tropical Forest of Mexico Are Affected by Phytophthora cinnamomi, Phylogenetically Classified into Phytophthora Subclade 7c
Authors: Andrade-Hoyos Petra , Romero-Arenas Omar , Silva-Rojas Hilda Victoria , Luna-Cruz Alfonso , Espinoza-Pérez José , Mendieta-Moctezuma Aarón , Urrieta-Velázquez José Alberto
Published: February 2023

Cinnamon is a tree introduced to the lowlands of Mexico in the mid-16th century, but it spread to other places at the beginning of the 20th century due to its important commercial value as an aromatic spice. In the state of Veracruz, symptoms of dieback have been observed in 12-year-old cinnamon plantations cultivated in an agroforestry system, causing concern among producers. For this reason, the present investigation was carried out to determine the causal agent of these symptoms observed in cinnamon trees. Fifty symptomatic plants were recovered from established plantations. One hundred cinnamon root fragments showing dieback were selected and separated; isolates were made from tissue showing crown and root rot on clarified juice V-8 agar medium. After eight days, the growth of whitish coralloid mycelium with characteristics similar to the Phytophthora oomycete was consistently observed. Subsequently, the identity corresponding to P. cinnamomi was confirmed by morphological, taxonomic studies and Bayesian inference of the rDNA internal transcribed spacer. The pathogenicity test was performed on 20 6-month-old cinnamon plants grown in pots by inoculating 2.5 × 104/mL of zoospores around the roots. Control plants were inoculated with sterile distilled water and kept in a greenhouse under conditions controlled. After five weeks, symptoms of root rot were observed in the inoculated plants; however, the control group plants remained healthy. The results showed that P. cinnamomi subclade 7c was responsible for the symptoms observed in lowland cinnamon plantations in Mexico. Our findings suggest that this phytopathogen is a new threat for cinnamon growers; likewise, it is recommended that growers implement management strategies to avoid its introduction into nurseries or new plantations that could be susceptible to this pathogen.
Bio-Fertilizers Reduced the Need for Mineral Fertilizers in Soilless-Grown Capia Pepper
Authors: Dasgan Hayriye Yildiz , Yilmaz Mehmet , Dere Sultan , Ikiz Boran , Gruda Nazim S.
Published: February 2023

Soilless cultivation is extensively used in the greenhouse industry. Recently, hydroponic cultivation of capia pepper has become popular among growers. Capia pepper is harvested at the red maturity stage, and intensive mineral fertilizers are usually used for soilless cultivation. This study was performed in a greenhouse during spring under Mediterranean climatic conditions. The effects of bacteria and mycorrhiza on capia pepper plant growth, yield, fruit quality, and nutrition were investigated. Furthermore, the synergistic effects of these two bio-fertilizers were investigated. Our objective was to replace 20% of mineral fertilizers with bio-fertilizers in a soilless culture system. The use of 80% mineral fertilizers, in combination with mycorrhiza and bacteria, provided a 32.4% higher yield than the control (100% mineral fertilizer without bio-fertilizers). Moreover, the concentrations of N, P, K, Ca, Mg, Fe, Mn, Zn, and Cu in the leaves of pepper plants fed with the reduced mineral fertilizers combined with bio-fertilizers were higher than that of the control. In addition, fruit parameters, such as fruit weight, diameter, volume, the electric conductivity of the fruit juice, and total soluble solids, were significantly higher in this treatment compared to the control. Using 80% mineral fertilizer with only bacteria provided a 24.2% higher yield than the control. In conclusion, mineral fertilizers were successfully reduced by 20% using bacteria and mycorrhiza. These results provide an eco-friendly approach to a sustainable environment.
Effects of Soil Physical and Chemical Properties on the Quality of Nanjing ‘Yuhua’ Tea, a Type of Famous Green Tea
Authors: Liu Zemao , Yang Deyu , Zhang Guangtao , Zheng Lihong , Chen Chen , Sun Xin , Yu Fangyuan
Published: February 2023

Tea has become one of the most popular drinks worldwide because of its special taste and health benefits. ‘Yuhua’ tea is a famous specialty of Nanjing, China, a green tea produced from Camelia sinensis. It belongs to the green tea category and is one of the top ten most famous teas in China. The physical and chemical properties of soil are very important to the quality of tea. However, at present, there are few instances of research on the soil of the ‘Yuhua’ tea cultivation area. To provide the theoretical basis for improving the final quality of ‘Yuhua’ tea by soil management measures, the effects of the soil’s physical and chemical properties on the contents of important chemical components (free amino acids, tea polyphenols, and caffeine) of ‘Yuhua’ tea in three different cultivation areas in Nanjing were studied. The quality of ‘Yuhua’ tea is greatly influenced by the physical and chemical properties of the soil in which the tea plant grows. The free amino acid content and tea polyphenol content of tea leaves were significantly and negatively correlated with soil bulk density, pH, and water-soluble calcium content, while a significantly positive correlation was noticed between the two criteria and soil effective nitrogen, phosphorus, and potassium content. Additionally, the growth of the tea tree will be hampered and perhaps stressed if the soil’s helpful mineral concentration is too low. The tea tree may produce more caffeine as a result, which could lower the quality of the tea leaves. Therefore, implementing targeted soil management techniques is the key to promoting tea tree growth and improving tea quality. This study laid the foundation for the adoption of corresponding soil management measures to improve the quality of ‘Yuhua’ tea.
Heavy Metal Analysis and Health Risk Assessment of Potato (Solanum tuberosum L.) Cultivars irrigated with Fly Ash-Treated Acid Mine Drainage
Authors: Raletsena Maropeng Vellry , Mongalo Nkoana Ishmael , Munyai Rabelani
Published: February 2023

In water-scant regions, the reuse of (un)treated acid mine drainage effluent (AMD) water for crop irrigation has turned into a prerequisite. The study assesses the levels of heavy metals, and health risk assessment in two potato crop cultivars, namely, Fianna and Lady rosetta (both determinate and indeterminate) when exposed to irrigation with different fly ash: acid mine drainage amelioration ratios. The study investigates the health risk assessment in the potato tissues namely, stem, tubers, new and old leaves of the potato cultivars. The treatments constituted a control, 50% FA: AMD, 75% FA: AMD ratio, and 100% AMD (untreated AMD). The results showed that the heavy metals of plants irrigated with AMD mixed with FA was significantly affected differently at harvest. In summary, the concentration of Cd was over the WHO acceptable standards in untreated acid mine drainage water. Fianna recorded 1.34 mg/kg while a notably decrease was observed in Lady rosetta with (1.01 mg/kg). In any case, FA was proven to significantly lessen the Cd particles in both FA-AMD ratios: Cd content was 0.98 mg/kg and 0.84 mg/kg in 50% FA: AMD treatment for Fianna and Lady rosetta separately, while the recommended maximum limit is 0.1 mg/kg. With the readings recorded, they are slightly high according to the CODEX general standard for food contaminants and toxins in food and feed (CODEX STAN 193-1995). Then again, in 75% FA: AMD ratio, the Cd concentration was 0.04 mg/kg and 0.03 mg/kg for Fianna and Lady rosetta exclusively. It is in this way obvious that FA adsorbed the Cd ions, and the two cultivars fulfill the CODEX guideline, nonetheless the potato crop irrigated with a 75% FA: AMD ratio can be consumed by humans without causing any detrimental effects.
The Impact of Urbanization on Urban Heat Island: Predictive Approach Using Google Earth Engine and CA-Markov Modelling (2005–2050) of Tianjin City, China
Authors: Ullah Nadeem , Siddique Muhammad Amir , Ding Mengyue , Grigoryan Sara , Khan Irshad Ahmad , Kang Zhihao , Tsou Shangen , Zhang Tianlin , Hu Yike , Zhang Yazhuo
Published: February 2023

Urbanization has adverse environmental effects, such as rising surface temperatures. This study analyzes the relationship between the urban heat island (UHI) intensity and Tianjin city’s land cover characteristics. The land use cover change (LUCC) effects on the green areas and the land surface temperature (LST) were also studied. The land cover characteristics were divided into five categories: a built-up area, an agricultural area, a bare area, a forest, and water. The LST was calculated using the thermal bands of spatial images taken from 2005 to 2020. The increase in the built-up area was mainly caused by the agricultural area decreasing by 11.90%. The average land surface temperature of the study area increased from 23.50 to 36.51 °C, and the region moved to a high temperature that the built-up area’s temperature increased by 1.5%. Still, the increase in vegetation cover was negative. From 2020 to 2050, the land surface temperature is expected to increase by 9.5 °C. The high-temperature areas moved into an aerial distribution, and the direction of urbanization determined their path. Urban heat island mitigation is best achieved through forests and water, and managers of urban areas should avoid developing bare land since they may suffer from degradation. The increase in the land surface temperature caused by the land cover change proves that the site is becoming more urbanized. The findings of this study provide valuable information on the various aspects of urbanization in Tianjin and other regions. In addition, future research should look into the public health issues associated with rapid urbanization.
3D Hand Scanning Methodology for Determining Protective Glove Dimensional Allowances
Authors: Szkudlarek Joanna , Zagrodny Bartłomiej , Zarychta Sandra , Zhao Xiaoxue
Published: February 2023

There are two types of dimensional allowance (inner and external) related to two distinct areas of occupational health and safety: those being a measure of fit of personal protective equipment (PPE) and those determining the safe and comfortable human interaction with tools and machines, e.g., the latter ones result from wearing PPE increasing the dimensions of the human body and generating limitations in the work environment. In this paper, they are taken to mean the difference between the dimensions of a bare and gloved hand (including glove construction and materials). Dimensional allowances are important in designing the work environment, e.g., machine control panels and tools. The absolute and relative maximum values of dimensional allowances determined in this study for a hand in a firefighter’s protective glove for the main anthropometric data are: 16.90 mm (5.90%) for length, 12.00 mm (13.77%) for width, and 15.70 mm (7.96%) for circumference. The obtained results are useful for designers, and especially for designing keys on control panels and LCD touch displays and monitors integrated with machines.
Adsorption of Fluoroquinolone Antibiotics from Water and Wastewater by Colemanite
Authors: Hacıosmanoğlu Gül Gülenay , Arenas Marina , Mejías Carmen , Martín Julia , Santos Juan Luis , Aparicio Irene , Alonso Esteban
Published: February 2023

Pharmaceutical residues in water and wastewater have become a worldwide problem with environmental and public health consequences. Antibiotics are of special importance because of the emergence of antibiotic-resistant genes. This study evaluates the adsorptive removal of four common fluoroquinolone antibiotics by using natural colemanite as an alternative adsorbent for the first time. Batch adsorption experiments were conducted for the mixture of fluoroquinolones as well as for individual compounds during the isotherm studies. Adsorption kinetic results indicated that the process followed the pseudo-second-order (PSO) model, while the Langmuir model described the sorption isotherms. The effects of pH and temperature on adsorption performance were determined, and the results indicated that the adsorption was endothermic and spontaneous, with increasing randomness at the solid–liquid interface. The effects of real water and wastewater matrices were tested by using tap water, surface water, and wastewater samples. Reusability experiments based on five adsorption–desorption cycles indicated that the adsorption performance was mostly retained after five cycles. The adsorption mechanism was elucidated based the material characterization before and after adsorption. The results indicate that colemanite can be used as an effective and reusable adsorbent for fluoroquinolone antibiotics as well as for other pollutants with similar physicochemical properties.
Establishing Self-Harm Registers: The Role of Process Mapping to Improve Quality of Surveillance Data Globally
Authors: Bebbington Emily , Poole Rob , Kumar Sudeep Pradeep , Krayer Anne , Krishna Murali , Taylor Peter , Hawton Keith , Raman Rajesh , Kakola Mohan , Srinivasarangan Madhu , Robinson Catherine
Published: February 2023

Self-harm registers (SHRs) are an essential means of monitoring rates of self-harm and evaluating preventative interventions, but few SHRs exist in countries with the highest burden of suicides and self-harm. Current international guidance on establishing SHRs recommends data collection from emergency departments, but this does not adequately consider differences in the provision of emergency care globally. We aim to demonstrate that process mapping can be used prior to the implementation of an SHR to understand differing hospital systems. This information can be used to determine the method by which patients meeting the SHR inclusion criteria can be most reliably identified, and how to mitigate hospital processes that may introduce selection bias into these data. We illustrate this by sharing in detail the experiences from a government hospital and non-profit hospital in south India. We followed a five-phase process mapping approach developed for healthcare settings during 2019–2020. Emergency care provided in the government hospital was accessed through casualty department triage. The non-profit hospital had an emergency department. Both hospitals had open access outpatient departments. SHR inclusion criteria overlapped with conditions requiring Indian medicolegal registration. Medicolegal registers are the most likely single point to record patients meeting the SHR inclusion criteria from multiple emergency care areas in India (e.g., emergency department/casualty, outpatients, other hospital areas), but should be cross-checked against registers of presentations to the emergency department/casualty to capture less-sick patients and misclassified cases. Process mapping is an easily reproducible method that can be used prior to the implementation of an SHR to understand differing hospital systems. This information is pivotal to choosing which hospital record systems should be used for identifying patients and to proactively reduce bias in SHR data. The method is equally applicable in low-, middle- and high-income countries.
Types and Characteristics of Stress Coping in Women Undergoing Infertility Treatment in Korea
Authors: Choi Yumi , Moon So-Hyun
Published: February 2023

The purpose of this study was to identify the characteristics and predictors of types of stress coping in women undergoing infertility treatment. The cross-sectional study included 120 women who were receiving infertility treatment at infertility hospitals. Self-report questionnaires were used to measure. K-means cluster analysis and multinomial logistic regression were used to examine the characteristics and predictors of stress-coping types. Out of all the women undergoing infertility treatment who completed a self-report survey, 30.8% had a weak mixed coping type, 35.9% had a strong mixed coping type, and 33.3% had a passive coping type. The strong mixed treatment type was compared to weak mixed treatment type, with the following results: infertility adaptation (OR = 17.71, p < 0.000), spousal support (OR = 4.50, p = 0.021), infertility counseling experience (OR = 7.14, p = 0.010). Comparing the strong mixed coping type with the passive coping type, resilience (OR = 9.11, p < 0.000) was shown. It is necessary to strengthen resilience and provide a receptive attitude and spousal support to women undergoing infertility adaptation to help them relieve stress and develop functional coping.
Facial Soft Tissue Thickness Differences among Three Skeletal Classes in Korean Population Using CBCT
Authors: Park Eunseo , Chang Jisuk , Park Jongtae
Published: February 2023

Studies related to facial soft tissue thickness (FSTT) have been conducted since the late 19th century. Soft tissue is any tissue in the body that is not hardened by ossification or calcification processes, such as bones and teeth; and varies according to sex, age, race, and nutritional status. Forensically, soft tissue thickness plays an important role in cases where a cadaver has no unique characteristics; and the remains cannot be identified through DNA analysis, fingerprints, or examination of dental records. Therefore, the results of the current study suggest that the average thickness of the three skeletal classes (i.e., straight, concave, and convex) should be used for face restoration and forensic art research. It is thought that the current study’s results will be invaluable in the fields of forensic science, forensic art, anthropology, and dentistry. As a result, gender differences were observed in all classes, and the facial tissue thickness in Korean adults differed according to gender and occlusion type.
Quality of Sex Life in Intestinal Stoma Patients—A Literature Review
Authors: Paszyńska Wiktoria , Zborowska Katarzyna , Czajkowska Mariola , Skrzypulec-Plinta Violetta
Published: February 2023

Introduction: Stoma surgery may reduce the quality of life, including sex life. A literature review was undertaken to explore what factors impact on the sexual health and sexuality of people with a stoma. Methodology: A review of the literature was undertaken using the online databases Cochrane, PsychInfo, Embase and Pubmed. The search was limited to articles on colostomates and ileostomates in the English language that were peer-reviewed and written in the past 5 years. Results: Intestinal stoma surgery affects many aspects of a patient’s life, including body image, relationship with a partner and quality of sex life. The introduction of perioperative educational programmes for patients qualified for ostomy surgery and their relatives will provide the necessary support in the face of physical and mental difficulties that may be associated with the procedure.
Willingness to Compromise Scale: Italian Validation and Assessment of the Relationship with Career Decision Self-Efficacy and Career Adaptability during School-to-Work Transition
Authors: Parola Anna
Published: February 2023

Willingness to compromise is defined as the propensity to accept an alternative career-related option that was not the one initially desired. In the literature, there is a validated scale for measuring willingness to compromise but not an Italian validation. Thus, Study 1 aimed to test the psychometric proprieties of the Willingness to Compromise Scale in a sample of 282 Italian university students. Confirmatory factor analyses were performed showing a second-order factorial structure with two well-separated first-order factors, i.e., compromising and adapting. Study 2 focused on the predicting role of willingness to compromise on career decision self-efficacy and the mediating role of career adaptability in this relationship. The sample consisted of 237 Italian university students. A mediation analysis with a 5000-bootstrap resampling procedure was computed. The results showed that willingness to compromise predicts both career decision self-efficacy and career adaptability, while career adaptability mediates the relationship between willingness to compromise and career decision self-efficacy. These findings allowed the discussion of practical implications for career guidance intervention aimed to support school-to-work transitions.
Editorial on the Research Topic of Sports Training and the Promotion of Physical Health
Authors: Tannheimer Markus
Published: February 2023

Sport activities are a deciding factor in maintaining or achieving physical health [...]
Effect of Turning Frequency on the Survival of Fecal Indicator Microorganisms during Aerobic Composting of Fecal Sludge with Sawdust
Authors: Manga Musa , Muoghalu Chimdi , Camargo-Valero Miller A. , Evans Barbara E.
Published: February 2023

The study investigated the effect of turning frequency on survival of fecal indicator pathogens (E. coli, Enterococcus spp., Salmonella spp. and helminth eggs) during fecal sludge (FS) co-composting with sawdust. Dewatered FS was mixed with sawdust and composted on a pilot scale using different turning frequencies—i.e., 3 days (3TF), 7 days (7TF), and 14 days (14TF). Composting piles were monitored weekly for survival of fecal indicator microorganisms and evolution of selected physical and chemical characteristics for 14 weeks. Our results show that turning frequency has a statistically significant (p < 0.05) effect on pathogen inactivation in FS compost. The 3TF piles exhibited shorter pathogen inactivation periods (8 weeks) than 7TF and 14TF piles (10 weeks). Temperature-time was found to be the major factor responsible for the survival of pathogens in FS composting piles, followed by indigenous microbial activities and toxic by-products (monitored as NH4+-N). Our study findings suggest that even at low composting temperatures, the high turning frequency can enhance pathogen inactivation. This is a significant finding for composting activities in some rural areas where suitable organic solid waste for co-composting with FS to attain the recommended high thermophilic conditions could be greatly lacking.
The Role of Cognition and Social Factors in Competition: How Do People with Intellectual Disabilities Respond to Opponents?
Authors: Sakalidis Kandianos Emmanouil , Menting Stein Gerrit Paul , Hettinga Florentina Johanna
Published: February 2023

Exploring pacing behaviour in people with intellectual disabilities (ID) in competition will help to better understand the impact of cognition and social environment in sports, providing support for the shaping of proper inclusive sports environments. The present experimental study aimed to (1) compare the pacing behaviour and performance between people with and without ID who are inexperienced in cycling and (2) investigate how these are influenced by an opponent. Participants with (n = 8) and without ID (n = 10) performed two randomised 4-km maximal cycling trials, alone and against an opponent. Non-parametric tests for repeated measures data (p ≤ 0.05) revealed that people with ID cycled slower, but with higher inter-individual variation (both conditions) and paced themselves differently compared to people without ID when competing against an opponent. In contrast to the previous literature in athletes without ID, the presence of a faster opponent resulted in a decrease in the performance in the participants with ID. The negative influence of the opponent highlights the potential difficulties people with ID experience to adequately use their opponents to enhance their self-regulatory processes and optimize their pacing and performance in maximal exercise trials. Coaches who want to offer inclusive sports environments for people with ID could take these findings into consideration.
Place-Based Policies and Carbon Emission Efficiency: Quasi-Experiment in China’s Old Revolutionary Base Areas
Authors: Wen Huwei , Liu Yutong , Huang Yulin
Published: February 2023

Regional imbalance is a typical feature of economic and social development in China, and place-based policies aimed at promoting balanced regional development may bring challenges to low-carbon goals. This study uses the panel data of China’s prefecture-level cities from 2003 to 2019 to investigate the impact of place-based policies on carbon emission efficiency using a quasi-experimental method. Results indicate that place-based policies significantly reduce the regional total-factor carbon emission efficiency. The difference-in-differences method based on propensity score matching and entropy balancing matching consistently supports the finding that carbon emission efficiency decreases after policy intervention. Place-based policies lead to a significant decline in capital allocation efficiency but have an insignificant impact on labor allocation efficiency. Moreover, place-based policies result in the expansion of carbon-intensive industries but hinder the progress of the financial technology of financial institutions. Nevertheless, place-based policies do not lead to the deterioration of environmental quality. Among the advantages of these policies are the significant promotion of regional digitization and increased fiscal expenditure on science and technology. Political promotion, carbon regulation, trade policies, and other conditional factors may be optimally designed to promote low-carbon development in the old revolutionary areas.
Prehabilitation in Cardiovascular Surgery: The Effect of Neuromuscular Electrical Stimulation (Randomized Clinical Trial)
Authors: Sumin Alexey N. , Oleinik Pavel A. , Bezdenezhnykh Andrey V. , Bezdenezhnykh Natalia A.
Published: February 2023

Objective: We aimed to determine the effects of prehabilitation with neuromuscular electrical stimulation (NMES) on muscle status and exercise capacity in patients before cardiac surgery. Methods: Preoperative elective cardiac surgery patients were randomly assigned to the NMES group or control group. Intervention in the NMES group was 7–10 sessions, whereas the control group carried out breathing exercises and an educational program. The outcome measures included a six-minute walk test (6MWT) and a muscle status assessment (knee extensor strength (KES), knee flexor strength (KFS), and handgrip strength (HS)) after the course of prehabilitation. Results: A total of 122 patients (NMES, n = 62; control, n = 60) completed the study. During the NMES course, no complications occurred. After the course prehabilitation KES, KFS, and 6MWT distance were significantly increased (all p < 0.001) in the NMES group compared to the control. There was no significant difference in HS before surgery. Conclusions: A short-term NMES course before cardiac surgery is feasible, safe, and effective to improve preoperative functional capacity (six-minute walk distance) and the strength of stimulated muscles.
The Potential Impact of Cycling on Urban Transport Energy and Modal Share: A GIS-Based Methodology
Authors: Monteiro João , Sousa Nuno , Natividade-Jesus Eduardo , Coutinho-Rodrigues João
Published: February 2023

This article presents a methodology to estimate the maximum potential impact of a well-built and conserved cycling infrastructure, measured as modal share for accessibility trips, as well as the associated transport energy that can be saved in those trips. The methodology uses Geographic Information Systems (GIS) to estimate active trip probabilities, from which the output variables can be obtained. It was applied to a case study of a mid-sized city in Southern Europe, and results show that an adequate cycling infrastructure can achieve cycling mode share in that city on par with the world’s most cycling-friendly cities. Concerning transport energy, a full-cycling scenario is estimated to reduce fossil energy intensity by approximately 20%, mainly by inducing a mode change for residents on the closest outskirts. It is also argued that cycling investment in commuting routes will have the most impact on reducing fossil transport energy.
Therapeutic Potential of Dimethyl Fumarate in Counteract Oral Squamous Cell Carcinoma Progression by Modulating Apoptosis, Oxidative Stress and Epithelial–Mesenchymal Transition
Authors: Basilotta Rossella , Lanza Marika , Filippone Alessia , Casili Giovanna , Mannino Deborah , De Gaetano Federica , Chisari Giulia , Colarossi Lorenzo , Motta Gianmarco , Campolo Michela , Cuzzocrea Salvatore , Paterniti Irene , Esposito Emanuela
Published: February 2023

Oral squamous cell carcinoma (OSCC) is a common human tumor, that originates from buccal mucosa and the tongue, associated with a high mortality rate. Currently, the treatment for OSCC involves surgery, chemotherapy and radiotherapy; however, survival outcomes for OSCC patients remain poor. For this reason, it is necessary to investigate new therapeutic strategies to counteract the progression of OSCC. In this study, we aimed to evaluate the role of dimethyl fumarate (DMF) in modulation of OSCC progression, both in vitro and in an in vivo orthotopic xenograft model. In vitro results revealed that DMF was able to reduce the expression of anti-apoptotic factors as BCL-2 and increased the expression of pro-apoptotic factors as Bax, Caspase-3 and BID. DMF appears to be involved in the modulation of oxidative stress mediators, such as MnSOD and HO-1. Furthermore, DMF showed to reduce the migratory ability of tumor cells and to modulate the expression of markers of epithelial-mesenchymal transition (EMT), as N-cadherin and E-cadherin. The in vivo study confirmed the data obtained in vitro significantly decreasing tumor mass and also reducing oxidative stress and apoptosis. Therefore, based on these results, the use of DMF could be considered a promising strategy to counteract oral cancer progression.
Employing Supervised Algorithms for the Prediction of Nanomaterial’s Antioxidant Efficiency
Authors: Mirzaei Mahsa , Furxhi Irini , Murphy Finbarr , Mullins Martin
Published: February 2023

Reactive oxygen species (ROS) are compounds that readily transform into free radicals. Excessive exposure to ROS depletes antioxidant enzymes that protect cells, leading to oxidative stress and cellular damage. Nanomaterials (NMs) exhibit free radical scavenging efficiency representing a potential solution for oxidative stress-induced disorders. This study aims to demonstrate the application of machine learning (ML) algorithms for predicting the antioxidant efficiency of NMs. We manually compiled a comprehensive dataset based on a literature review of 62 in vitro studies. We extracted NMs’ physico-chemical (P-chem) properties, the NMs’ synthesis technique and various experimental conditions as input features to predict the antioxidant efficiency measured by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Following data pre-processing, various regression models were trained and validated. The random forest model showed the highest predictive performance reaching an R2 = 0.83. The attribute importance analysis revealed that the NM’s type, core-size and dosage are the most important attributes influencing the prediction. Our findings corroborate with those of the prior research landscape regarding the importance of P-chem characteristics. This study expands the application of ML in the nano-domain beyond safety-related outcomes by capturing the functional performance. Accordingly, this study has two objectives: (1) to develop a model to forecast the antioxidant efficiency of NMs to complement conventional in vitro assays and (2) to underline the lack of a comprehensive database and the scarcity of relevant data and/or data management practices in the nanotechnology field, especially with regards to functionality assessments.
The Role of the Interleukin-1 Family in Complications of Prematurity
Authors: Green Elys A. , Garrick Steven P. , Peterson Briana , Berger Philip J. , Galinsky Robert , Hunt Rod W. , Cho Steven X. , Bourke Jane E. , Nold Marcel F. , Nold-Petry Claudia A.
Published: February 2023

Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter injury (WMI, brain), retinopathy of prematurity (ROP, eyes), necrotizing enterocolitis (NEC, gut) and sepsis are among the major causes of long-term morbidity in infants born prematurely. Though the origins are multifactorial, inflammation and in particular the imbalance of pro- and anti-inflammatory mediators is now recognized as a key driver of the pathophysiology underlying these illnesses. Here, we review the involvement of the interleukin (IL)-1 family in perinatal inflammation and its clinical implications, with a focus on the potential of these cytokines as therapeutic targets for the development of safe and effective treatments for early life inflammatory diseases.
Unravelling How Single-Stranded DNA Binding Protein Coordinates DNA Metabolism Using Single-Molecule Approaches
Authors: Xu Longfu , Halma Matthew T. J. , Wuite Gijs J. L.
Published: February 2023

Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double helix from re-annealing and maintaining genome integrity. In the meantime, they interact and coordinate with various proteins vital for DNA replication, recombination, and repair. Although SSB is essential for DNA metabolism, proteins of the SSB family have been long described as accessory players, primarily due to their unclear dynamics and mechanistic interaction with DNA and its partners. Recently-developed single-molecule tools, together with biochemical ensemble techniques and structural methods, have enhanced our understanding of the different coordination roles that SSB plays during DNA metabolism. In this review, we discuss how single-molecule assays, such as optical tweezers, magnetic tweezers, Förster resonance energy transfer, and their combinations, have advanced our understanding of the binding dynamics of SSBs to ssDNA and their interaction with other proteins partners. We highlight the central coordination role that the SSB protein plays by directly modulating other proteins’ activities, rather than as an accessory player. Many possible modes of SSB interaction with protein partners are discussed, which together provide a bigger picture of the interaction network shaped by SSB.