bluuebunny/crossref_metadata_2025 huggingface dataset:
Leiomyoma of the prostate: A case report and systematic review
Authors: Wang Shangren , Huang Shiqiao , Pan Yang , Ma Yong , Kang Jiaqi , Liu Li , Liu Xiaoqiang
Published: January 2023

Purpose

It is rare to find a large leiomyoma in the prostate, especially in that of a young man. This case report and systematic review provides additional information on the diagnosis, distinguishing features of imaging examinations, and treatment options.

Patients and Methods

We report on the case of a thirty-year-old man with a large leiomyoma of the prostate. MRI of the prostate revealed a round mass in the posterior lobe, 8.0 × 8.0 × 5.5 cm in size. With the assistance of laparoscopy, we resected the prostate mass completely and spared this organ. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews (PRISMA) including English language published reports, from 1970 to December 2021.

Results

Urinary and erectile functioning was preserved postoperatively. After a year of follow-up, no evidence of recurrence emerged. A total of 21 studies were included for analysis.

Conclusions

A medical history of no, or few, lower urinary tract symptoms; the characteristics of a benign tumor in imaging examinations; and negative tumor markers should be included in any differential diagnosis of leiomyoma of the prostrate. A prostate biopsy should be performed before the preparative radical prostatectomy and choose nonsurgical treatment to confirm the diagnosis. Nowadays, minimally invasive surgery is the preferred effective option for this disease. It is a rare recurrence after its removal by means of surgery.
On the Numerical Treatment of the Temporal Discontinuity Arising from a Time-Varying Point Mass Attachment on a Waveguide
Authors: Manolis George D. , Dadoulis Georgios I.
Published: January 2023

A vibrating pylon, modeled as a waveguide, with an attached point mass that is time-varying poses a numerically challenging problem regarding the most efficient way for eigenvalue extraction. The reason is three-fold, starting with a heavy mass attachment that modifies the original eigenvalue problem for the stand-alone pylon, plus the fact that the point attachment results in a Dirac delta function in the mixed-type boundary conditions, and finally the eigenvalue problem becomes time-dependent and must be solved for a sequence of time steps until the time interval of interests is covered. An additional complication is that the eigenvalues are now complex quantities. Following the formulation of the eigenvalue problem as a system of first-order, time-dependent matrix differential equations, two eigenvalue extraction methods are implemented and critically examined, namely the Laguerre and the QR algorithms. The aim of the analysis is to identify the most efficient technique for interpreting time signals registered at a given pylon as a means for detecting damage, a procedure which finds application in structural health monitoring of civil engineering infrastructure.
Design of a Quasi-Direct Drive Actuator with Embedded Pulley for a Compact, Lightweight, and High-Bandwidth Exosuit
Authors: Yang Jaeha , Moon Junyoung , Ryu Jaewook , Kim Jehyeok , Nam Kimoon , Park Sungjin , Kim Yoosun , Lee Giuk
Published: January 2023

Although exosuits have several advantages compared to exoskeleton type of wearable robots, they have limitations, such as bulkiness and low control performance. This study addresses the design and evaluation of a compact, lightweight, and highly responsive actuator to be used for exosuits, based on the Quasi-Direct Drive (QDD) actuation. The design requirements of the actuator were set based on the actuation system used in the state-of-the-art exosuit from Harvard University (HE) so that it could be an improvement compared to HE. Several design concepts were comparatively evaluated to select the optimal design, and a design for the pulley embedded QDD (PEQDD) actuator was selected. The PEQDD was fabricated using mechanical components selected based on the design constraints or designed through mechanical analysis. Using a dynamometer, the efficiency map of the PEQDD was drawn. The control bandwidth comparison test with the motor originally used for HE showed improved bandwidth from 6.25 Hz to 20 Hz. Preliminary testing was done in walking and running conditions using an exosuit utilizing PEQDD. The test results showed that the actuator performance met all the design requirements.
New Perspectives on Entrepreneurship Education: Introduction
Authors: Mets Tõnis , Kozlinska Inna , Raudsaar Mervi , Trabskaia Iuliia
Published: January 2023

Entrepreneurship education (EE) plays an essential role in developing the competencies of modern knowledge-based societies and economies, the so-called 21st-century competencies (OECD 2018) [...]
Quartz Crystal Microbalances for Space: Design and Testing of a 3D Printed Quasi-Kinematic Support
Authors: Scaccabarozzi Diego , Saggin Bortolino , Magni Marianna , Corti Marco Giovanni , Valnegri Pietro , Palomba Ernesto , Longobardo Andrea , Dirri Fabrizio , Zampetti Emiliano
Published: January 2023

Outgassing or thruster’s generated contaminants are critical for optical surfaces and optical payloads because scientific measurements and, in general, the performances can be degraded or jeopardized by uncontrolled contamination. This is a well-known issue in space technology that is demonstrated by the growing usage of quartz crystal microbalances as a solution for measuring material outgassing properties data and characterizing the on-orbit contamination environment. Operation in space requires compatibility with critical requirements, especially the mechanical and thermal environments to be faced throughout the mission. This work provides the design of a holding structure based on 3D printing technology conceived to meet the environmental characteristics of space application, and in particular, to face harsh mechanical and thermal environments. A kinematic mounting has been conceived to grant compatibility with a large temperature range, and it has been designed by finite element methods to overcome loading during the launch phases and cope with a temperature working range down to cryogenic temperatures. Qualification in such environments has been performed on a mockup by testing a prototype of the holding assembly between −110 ∘C and 110 ∘C and allowing verification of the mechanical resistance and stability of the electrical contacts for the embedded heater and sensor in that temperature range. Moreover, mechanical testing in a random environment characterized by an RMS acceleration level of 500 m/s2 and excitation frequency from 20 to 2000 Hz was successfully performed. The testing activity allowed for validation of the proposed design and opened the road to the possible implementation of the proposed design for future flight opportunities, also onboard micro or nanosatellites. Moreover, exploiting the manufacturing technology, the proposed design can implement an easy assembling and mounting of the holding system. At the same time, 3D printing provides a cost-effective solution even for small series production for ground applications, like monitoring the contaminants in thermo-vacuum chambers or clean rooms, or depositions chambers.
Multidisciplinary Optimization and Analysis of Stratospheric Airships Powered by Solar Arrays
Authors: Tang Jiwei , Xie Weicheng , Zhou Pingfang , Yang Hui , Zhang Tongxin , Wang Quanbao
Published: January 2023

Stratospheric airships have much potential in military and commercial applications. Design, analysis and optimization of stratospheric airships involves complex trade-off of different disciplines, and hence a multidisciplinary approach is essential. This paper describes a methodology coupling several disciplines and involving seven design variables to obtain the optimal design of a stratospheric airship powered by solar arrays. A numerical method is established to calculate the output power of the solar array in the optimization process. The optimal solutions are obtained using hybrid algorithms. The methodology can obtain the optimal envelope shape, solar array layout and other general configurations of subsystems. Results show that the methodology was able to achieve a solution with a 19.2% reduction in airship volume compared to the value being part of an arbitrary initial set of airship parameters. In addition, a comparative study is carried out to highlight the importance of considerations of solar array layouts and array circumferential location. Furthermore, detailed sensitivity analysis shows that operating parameters of latitudes, heading angles and average resisting wind speeds have significant effects on the airship design and solar array layouts.
Cloning and Disease Resistance Analysis of the Maize ZmBON3 Gene
Authors: Zhang Chen , Qi Zhuo , Jiao Peng , Jiang Zhenzhong , Liu Siyan , Fan Sujie , Zhao Chunli , Ma Yiyong , Guan Shuyan
Published: January 2023

(1) Corn is the most widely planted food crop, feed crop, and economic crop in the world, and plays an important role in agricultural production and national economy development. The copine gene, also known as the BONZAI gene, encodes a Ca2+-dependent phospholipid membrane binding protein that is widely present in eukaryotes. It has been found that the copine protein is a negative regulator of disease resistance regulation and plays a key role in plants’ disease resistance response. In this study, the Agrobacterium-tumefacien-mediated method was used to successfully obtain T2 generation ZmBON3-gene-overexpressing plants and gene-edited plants. Related phenotypes and molecular identification showed that the disease resistance of overexpression plants was significantly reduced, and the disease resistance of gene-edited plants was significantly increased, which verified that the ZmBON3 gene was a negative regulatory gene. By detecting the physiological indexes related to defense, it was found that the content of H2O2 and the enzyme active water of CAT, POD, SOD, and PAL in ZmBON3-gene-edited plants was higher than those in the control plants and ZmBON3-gene-overexpressing plants, and the content of H2O2 and CAT, POD, and SOD in ZmBON3-gene-overexpressing plants was significantly higher than that in the control plants and ZmBON3-gene-overexpressing plants. The enzyme activity of PAL was the lowest. By detecting the expression of key genes of defense-related signaling pathways, it was found that ZmBON3 may be involved in the related defense processes mediated by the R gene, SA pathway, JA pathway, and ABA pathway. In addition, ZmBON3-geneedited plants showed obvious dwarf phenomenon at the seedling stage, but this did not affect the ear length, axis diameter, ear row number, and grain color.
Laissez-Faire Stallions? Males’ Fecal Cortisol Metabolite Concentrations Do Not Vary with Increased Female Turnover in Feral Horses (Equus caballus)
Authors: Jones Maggie M. , Nuñez Cassandra M. V.
Published: January 2023

Stress responses can be triggered by several physical and social factors, prompting physiological reactions including increases in glucocorticoid concentrations. In a population of feral horses (Equus caballus) on Shackleford Banks, North Carolina, females previously immunized with the immunocontraceptive agent porcine zona pellucida (PZP) change social groups (bands) more often than unimmunized females, disrupting the social stability within the population. We assessed the effects of increased female group changing behavior (or female turnover) on individual male stress by comparing fecal cortisol metabolite (FCM) concentrations among stallions experiencing varying amounts of female group changing behavior. FCM concentrations did not significantly correlate with female turnover. Similarly, FCM concentrations were not dependent upon the timing of female group changing behavior. These findings suggest that female turnover rate has little influence on physiological measures of stress in associated stallions. That said, Shackleford stallions experiencing increased female turnover do engage in behaviors typically associated with stress (increased vigilance, highly escalated male-male conflicts). Future work should compare FCM concentrations across time within populations and among populations managed under different strategies to better isolate factors influencing stallion stress physiology. Such studies are especially important if we are to determine how changes in female behavior related to immunocontraception impact physiological and behavioral indicators of stress for non-target animals. Finally, our study highlights the importance of considering both physiological and behavioral measures when investigating animal responses to potentially challenging situations.
Highly Effective Frontal Stunning Procedure Using a Pneumatic Penetrating Captive Bolt in Water Buffaloes
Authors: Molnar-Fernández Valeria , Muñoz-Vargas Lohendy , Romero-Zúñiga Juan José , Araya-Rodríguez Gustavo
Published: January 2023

An effective frontal stunning procedure in water buffaloes was assessed using a pneumatic penetrating captive bolt (PPCB) with high air pressure. The study contemplated two phases; first, 352 buffaloes and 168 post-mortem heads were evaluated to determine the most effective anatomical site for stunning. Then, the second phase (n = 182) was used to validate the stunning procedure at the discovered anatomical site in the first phase, which was located 8 cm dorsal above the middle of the forehead on an “X” formed between the eyes and the base of the contralateral horns, and 2 cm lateral, avoiding the midline, where the skull tended to narrow. A total of 95.1% of buffaloes received effective stunning at the first shot with evidence of the presence of collapse, absence of rhythmic breathing, and absence of ocular reflexes (corneal and palpebral). There were no differences in the stunning efficacy by sex, breed, or skull thickness. These findings demonstrated that stunning with a PPCB at pressures of 1379–1516.8 KPa (200–220 pounds per square inch (psi)) in the site reported here produces a highly effective stunning at the first shot in water buffaloes.
Online SOPDT Model Identification Method Using a Relay
Authors: Kula Krzysztof S.
Published: January 2023

This paper describes a novel method for the online identification of an analog second-order plus dead time (SOPDT) model. It requires the measurement of four physical quantities, for which a relay is used. Based on these measurements, the parameters of the model or the regulator settings can be directly determined and used to autotune PI/PID controllers. The steps required to take the necessary measurements and the computational algorithms used to determine the model parameters are presented. The results of the simulation studies, including the measurements and calculations of the obtained models, are presented to demonstrate the effectiveness of the proposed method. Comparisons were made between the developed SOPDT model and the critically damped SOPDT model that is often used for high-order inertial plants.
Biological Scaffolds for Congenital Heart Disease
Authors: Harris Amy G. , Salih Tasneem , Ghorbel Mohamed T. , Caputo Massimo , Biglino Giovanni , Carrabba Michele
Published: January 2023

Congenital heart disease (CHD) is the most predominant birth defect and can require several invasive surgeries throughout childhood. The absence of materials with growth and remodelling potential is a limitation of currently used prosthetics in cardiovascular surgery, as well as their susceptibility to calcification. The field of tissue engineering has emerged as a regenerative medicine approach aiming to develop durable scaffolds possessing the ability to grow and remodel upon implantation into the defective hearts of babies and children with CHD. Though tissue engineering has produced several synthetic scaffolds, most of them failed to be successfully translated in this life-endangering clinical scenario, and currently, biological scaffolds are the most extensively used. This review aims to thoroughly summarise the existing biological scaffolds for the treatment of paediatric CHD, categorised as homografts and xenografts, and present the preclinical and clinical studies. Fixation as well as techniques of decellularisation will be reported, highlighting the importance of these approaches for the successful implantation of biological scaffolds that avoid prosthetic rejection. Additionally, cardiac scaffolds for paediatric CHD can be implanted as acellular prostheses, or recellularised before implantation, and cellularisation techniques will be extensively discussed.
Optimization of an Injectable, Resorbable, Bioactive Cement Able to Release the Anti-Osteoclastogenic Biomolecule ICOS-Fc for the Treatment of Osteoporotic Vertebral Compression Fractures
Authors: Banche-Niclot Federica , Corvaglia Ilaria , Cavalera Caterina , Boggio Elena , Gigliotti Casimiro Luca , Dianzani Umberto , Tzagiollari Antzela , Dunne Nicholas , Manca Antonio , Fiorilli Sonia , Vitale-Brovarone Chiara
Published: January 2023

Vertebral compression fractures are typical of osteoporosis and their treatment can require the injection of a cement through a minimally invasive procedure to restore vertebral body height. This study reports the development of an injectable calcium sulphate-based composite cement able to stimulate bone regeneration while inhibiting osteoclast bone resorption. To this aim, different types of strontium-containing mesoporous glass particles (Sr-MBG) were added to calcium sulphate powder to impart a pro-osteogenic effect, and the influence of their size and textural features on the cement properties was investigated. Anti-osteoclastogenic properties were conferred by incorporating into poly(lactic-co-glycolic)acid (PLGA) nanoparticles, a recombinant protein able to inhibit osteoclast activity (i.e., ICOS-Fc). Radiopaque zirconia nanoparticles (ZrO2) were also added to the formulation to visualize the cement injection under fluoroscopy. The measured cement setting times were suitable for the clinical practice, and static mechanical testing determined a compressive strength of ca. 8 MPa, comparable to that of human vertebral bodies. In vitro release experiments indicated a sustained release of ICOS-Fc and Sr2+ ions up to 28 days. Overall, the developed cement is promising for the treatment of vertebral compression fractures and has the potential to stimulate bone regeneration while releasing a biomolecule able to limit bone resorption.
Emerging Indications for Interventional Oncology: Expert Discussion on New Locoregional Treatments
Authors: Iezzi Roberto , Gangi Afshin , Posa Alessandro , Pua Uei , Liang Ping , Santos Ernesto , Kurup Anil N. , Tanzilli Alessandro , Tenore Lorenzo , De Leoni Davide , Filippiadis Dimitrios , Giuliante Felice , Valentini Vincenzo , Gasbarrini Antonio , Goldberg Shraga N. , Meijerink Martijn , Manfredi Riccardo , Kelekis Alexis , Colosimo Cesare , Madoff David C.
Published: January 2023

Interventional oncology (IO) employs image-guided techniques to perform minimally invasive procedures, providing lower-risk alternatives to many traditional medical and surgical therapies for cancer patients. Since its advent, due to rapidly evolving research development, its role has expanded to encompass the diagnosis and treatment of diseases across multiple body systems. In detail, interventional oncology is expanding its role across a wide spectrum of disease sites, offering a potential cure, control, or palliative care for many types of cancer patients. Due to its widespread use, a comprehensive review of the new indications for locoregional procedures is mandatory. This article summarizes the expert discussion and report from the “MIOLive Meet SIO” (Society of Interventional Oncology) session during the last MIOLive 2022 (Mediterranean Interventional Oncology Live) congress held in Rome, Italy, integrating evidence-reported literature and experience-based perceptions. The aim of this paper is to provide an updated review of the new techniques and devices available for innovative indications not only to residents and fellows but also to colleagues approaching locoregional treatments.
Comment on Billant et al. p53, A Victim of the Prion Fashion. Cancers 2021, 13, 269
Authors: Liebman Susan W. , Derkatch Irina L. , Park Sangeun , Park Sei-Kyoung
Published: January 2023

The p53 tumor suppressor is a central protein in the fight against cancer [...]
Multiple Roles of PLK1 in Mitosis and Meiosis
Authors: Kalous Jaroslav , Aleshkina Daria
Published: January 2023

Cells are equipped with a diverse network of signaling and regulatory proteins that function as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell division. A key regulator of cell division is polo-like kinase 1 (PLK1), a member of the serine/threonine kinase family that plays an important role in regulating the mitotic and meiotic cell cycle. The phosphorylation of specific substrates mediated by PLK1 controls nuclear envelope breakdown (NEBD), centrosome maturation, proper spindle assembly, chromosome segregation, and cytokinesis. In mammalian oogenesis, PLK1 is essential for resuming meiosis before ovulation and for establishing the meiotic spindle. Among other potential roles, PLK1 regulates the localized translation of spindle-enriched mRNAs by phosphorylating and thereby inhibiting the translational repressor 4E-BP1, a downstream target of the mTOR (mammalian target of rapamycin) pathway. In this review, we summarize the functions of PLK1 in mitosis, meiosis, and cytokinesis and focus on the role of PLK1 in regulating mRNA translation. However, knowledge of the role of PLK1 in the regulation of meiosis remains limited.
Effect of Different Application Modalities on the Bonding Performance of Adhesive Systems to Dentin: A Systematic Review and Meta-Analysis
Authors: Hardan Louis , Bourgi Rim , Cuevas-Suárez Carlos Enrique , Devoto Walter , Zarow Maciej , Monteiro Paulo , Jakubowicz Natalia , Zoghbi Amine El , Skaba Dariusz , Mancino Davide , Kharouf Naji , Haïkel Youssef , Lukomska-Szymanska Monika
Published: January 2023

Diverse types of dental adhesives exhibit different cytotoxic outcomes on cells in vitro. Currently, no standard adhesive application technique has so far been decisive for clinicians for better durability of resin–dentin bonds of adhesive systems. The purpose of this study was to systematically review the literature to evaluate the bonding performance of adhesive systems to dentin by using different application modalities. The systematic research strategy was conducted by two reviewers among multiple databases: PubMed, Scopus, Web of Science, Embase, and Scielo. In vitro studies reporting the effects of additional steps for the application of adhesive systems on the bond strength to dentin were selected. Meta-analysis was performed using Review Manager Software version 5.3.5 using the random effects model. The methodological quality of each in vitro study was assessed according to the parameters of a previous systematic review. The electronic research through different databases generated a total of 8318 references. After the examination of titles and abstracts, a total of 106 potentially relevant studies accessed the full-text evaluation phase. After full-text examination, 78 publications were included for the qualitative analysis, and 68 studies were included in the meta-analysis. Regarding the etch-and-rinse adhesive systems, the application modalities that improved the overall bond strength were the application of a hydrophobic resin layer (p = 0.005), an extended application time (p < 0.001), an application assisted by an electric current (p < 0.001), a double-layer application (p = 0.05), the agitation technique (p = 0.02), and the active application of the adhesive (p < 0.001). For self-etch adhesive systems, the techniques that improved the overall bond strength were the application of a hydrophobic resin layer (p < 0.001), an extended application time (p = 0.001), an application assisted by an electric current (p < 0.001), a double-layer application (p < 0.001), the agitation technique (p = 0.01), and the active application of the adhesive (p < 0.001). The in vitro evidence suggests that the application of adhesive systems using alternative techniques or additional strategies may be beneficial for improving their bond strength to dentin. The application modalities that favored the overall bond strength to dentin were an extended application time, a double-layer application, an application assisted by an electric current, the active application of the adhesive, and the application of a hydrophobic resin layer. Worth mentioning is that some techniques are intended to increase the degree of the conversion of the materials, and therefore, improvements in the biocompatibility of the materials can be expected.
The Consequences of GBA Deficiency in the Autophagy–Lysosome System in Parkinson’s Disease Associated with GBA
Authors: Pradas Eddie , Martinez-Vicente Marta
Published: January 2023

GBA gene variants were the first genetic risk factor for Parkinson’s disease. GBA encodes the lysosomal enzyme glucocerebrosidase (GBA), which is involved in sphingolipid metabolism. GBA exhibits a complex physiological function that includes not only the degradation of its substrate glucosylceramide but also the metabolism of other sphingolipids and additional lipids such as cholesterol, particularly when glucocerebrosidase activity is deficient. In the context of Parkinson’s disease associated with GBA, the loss of GBA activity has been associated with the accumulation of α-synuclein species. In recent years, several hypotheses have proposed alternative and complementary pathological mechanisms to explain why lysosomal enzyme mutations lead to α-synuclein accumulation and become important risk factors in Parkinson’s disease etiology. Classically, loss of GBA activity has been linked to a dysfunctional autophagy–lysosome system and to a subsequent decrease in autophagy-dependent α-synuclein turnover; however, several other pathological mechanisms underlying GBA-associated parkinsonism have been proposed. This review summarizes and discusses the different hypotheses with a special focus on autophagy-dependent mechanisms, as well as autophagy-independent mechanisms, where the role of other players such as sphingolipids, cholesterol and other GBA-related proteins make important contributions to Parkinson’s disease pathogenesis.
Effects of Vacancy Defects and the Adsorption of Toxic Gas Molecules on Electronic, Magnetic, and Adsorptive Properties of g−ZnO: A First-Principles Study
Authors: Shen Yang , Yuan Zhihao , Cui Zhen , Ma Deming , Yuan Pei , Yang Kunqi , Dong Yanbo , Wang Fangping , Li Enling
Published: January 2023

Using first principles based on density functional theory (DFT), the CO, NH3, NO, and NO2 gas adsorbed on intrinsic Graphite-like ZnO (g−ZnO) and vacancy-deficient g−ZnO were systematically studied. For intrinsic g−ZnO, the adsorption energy of NH3, NO, and NO2 adsorption defective g−ZnO systems increased significantly due to the introduction of Zn vacancy (VZn). Especially, for NH3, NO, and NO2 adsorbed Zn-vacancy g−ZnO (VZn/g−ZnO) systems increased to 1.366 eV, 2.540 eV and 2.532 eV, respectively. In addition, with the introduction of vacancies, the adsorption height of the gases adsorbed on VZn/g−ZnO system is significantly reduced, especially the adsorption height of the NH3 adsorbed on VZn/g−ZnO system is reduced to 0.686 Å. It is worth mentioning that the introduction of O-vacancy (VO) significantly enhances the charge transfer between NO or NO2 and VO/g−ZnO. This suggest that the defective g−ZnO is more suitable for detecting NH3, NO and NO2 gas. It is interesting to note that the adsorption of NO and NO2 gases gives rise to magnetic moments of 1 μB and 0.858 μB for g−ZnO, and 1 μB and 1 μB for VO/g−ZnO. In addition, VZn induced 1.996 μB magnetic moments for intrinsic g−ZnO, and the CO, NH3, NO and NO2 change the magnetic of VZn/g−ZnO. The adsorption of NO2 causes the intrinsic g−ZnO to exhibit metallic properties, while the adsorption of NH3 gas molecules causes VZn/g−ZnO also to show metallic properties. The adsorption of NO and NO2 causes VZn/g−ZnO to display semi-metallic properties. These results facilitate the enrichment of defect detection means and the design of gas detection devices.
Recent Advances in Chitosan-Based Hydrogels for Flexible Wearable Sensors
Authors: Wu Shuping , Xu Chao , Zhao Yiran , Shi Weijian , Li Hao , Cai Jiawei , Ding Fuyuan , Qu Ping
Published: January 2023

Flexible wearable sensors show great potential for applications in wearable devices, remote health monitoring, artificial intelligence, soft robotics, and artificial skin due to their stretchability, bendability, thinness and portability, and excellent electrical properties. Hydrogels have tunable mechanical properties, excellent biocompatibility, and flexibility, making them attractive candidates for wearable flexible sensors. Among them, tremendous efforts have focused on the advancement of chitosan-based hydrogels (CS-Gels) to realize multifunctional wearable sensing by modifying hydrogel networks with additives/nanofillers/functional groups. Recently, remarkable progress has been made in flexible wearable sensors. Herein, this review summarizes recent advances in CS-Gels wearable sensors for applications such as human motion monitoring, health monitoring, human-machine interface and soft robotics. Representative synthesis methods and strategies for CS-Gels are briefly described, the problems and deficiencies of CS-Gels for wearable sensors are discussed. Finally, the possible opportunities and challenges for the future development of CS-Gels flexible wearable devices are proposed.
Factors Participating in the Occurrence of Inflammation of the Lips (Cheilitis) and Perioral Skin
Authors: Lugović-Mihić Liborija , Špiljak Bruno , Blagec Tadeja , Delaš Aždajić Marija , Franceschi Nika , Gašić Ana , Parać Ena
Published: January 2023

Lip inflammation may manifest as mainly reversible cheilitis, mainly irreversible, or cheilitis connected to dermatoses or systemic diseases. Therefore, knowing a patient’s medical history is important, especially whether their lip lesions are temporary, recurrent, or persistent. Sometimes temporary contributing factors, such as climate and weather conditions, can be identified and avoided—exposure to extreme weather conditions (e.g., dry, hot, or windy climates) may cause or trigger lip inflammation. Emotional and psychological stress are also mentioned in the etiology of some lip inflammations (e.g., exfoliative cheilitis) and may be associated with nervous habits such as lip licking. To better manage cheilitis, it is also helpful to look for potential concomitant comorbidities and the presence of related diseases/conditions. Some forms of cheilitis accompany dermatologic or systemic diseases (lichen, pemphigus or pemphigoid, erythema multiforme, lupus, angioedema, xerostomia, etc.) that should be uncovered. Occasionally, lip lesions are persistent and involve histological changes: actinic cheilitis, granulomatous cheilitis, glandular cheilitis, and plasmacellular cheilitis. Perioral skin inflammation with simultaneous perioral dermatitis can have various causes: the use of corticosteroids and cosmetics, dysfunction of the skin’s epidermal barrier, a contact reaction to allergens or irritants (e.g., toothpaste, dental fillings), microorganisms (e.g., Demodex spp., Candida albicans, fusiform bacteria), hormonal changes, or an atopic predisposition. Epidermal barrier dysfunction can worsen perioral dermatitis lesions and can also be related to secondary vitamin or mineral deficiencies (e.g., zinc deficiency), occlusive emollient use, sunscreen use, or excessive exposure to environmental factors such as heat, wind, and ultraviolet light. Current trends in research are uncovering valuable information concerning the skin microbiome and disruption of the epidermal barrier of persons suffering from perioral dermatitis. Ultimately, an effective approach to patient management must take all these factors and new research into account.
On the Enhancement of Energy Storage Performance in Modified Relaxor Ferroelectric Ceramics for Pulsed Power Applications
Authors: Zhang Hao , Zhu Zhe , Yao Zhonghua , Hao Hua , Wang Lingyun , Cao Minghe , Liu Hanxing
Published: January 2023

Relaxor-type ferroelectrics show important potential in energy storage fields due to their significantly enhanced energy performance and good temperature stability compared to normal ferroelectrics. Here, a novel, high-performance ternary composition, (0.4−x)BiFeO3-xBi(Mg1/2Ti1/2)O3–0.6BaTiO3 (x = 0.2, 0.25, 0.3, 0.35, 0.4), was designed by compositional modulation, which displays typical relaxor characteristics. The optimum energy storage properties can be attained at x = 0.35, accompanied by energy efficiency of 84.87%, a promising energy storage density of 2.3 J/cm3 and good temperature stability of less than 10% over 20–160 °C. Moreover, the samples provide stable cycling fatigue after 105 cycles and a fast discharge time of t0.9 < 0.1 μs, indicative of promising applications in energy units.
Museum-Based Research on the Lice (Insecta: Phthiraptera) Infestations of Hummingbirds (Aves: Trochilidae)—Prevalence, Genus Richness and Parasite Associations
Authors: Oniki-Willis Yoshika , Willis Edwin O. , Lopes Leonardo E. , Rózsa Lajos
Published: January 2023

We documented the presence/absence of the eggs of Trochiloecetes, Trochiliphagus, and Leremenopon lice on over 50,000 hummingbird specimens (representing 348 species plus 247 additional subspecies) in four museums in the USA. (i) We provide sample estimates of infestation prevalence. (ii) Sample estimates of parasite genus richness increased with increasing host sample size. (iii) Host body mass did not correlate with parasite genus richness, even when controlled for sample size effects. (iv) The prevalence of Trochiliphagus and Trochiloecetes infestations did not correlate with host body mass, while the prevalence of Leremenopon exhibited a marginally significant positive correlation with host body mass. (v) The prevalence of Trochiliphagus and Leremenopon infestations correlated strongly and positively across host taxa (i.e., species or subspecies). (vi) The co-occurrence of Trochiliphagus and Trochiloecetes within the few largest host samples—i.e., within particular host taxa—was significantly more frequent than expected by chance. This latter association might indicate a true ecological relationship or, alternatively, might have emerged as an artifact of our sampling method. (vii) We found no relationship between host sexual size dimorphism and the prevalence of any of the three louse genera, contrary to the interspecific prediction of the Hamilton–Zuk hypothesis.
Tracing Patterns and Biodiversity Aspects of the Overlooked Skates and Rays (Subclass Elasmobranchii, Superorder Batoidea) in Greece
Authors: Chatzispyrou Archontia , Koutsikopoulos Constantin
Published: January 2023

Species belonging to the superorder Batoidea have been poorly assessed due to the lack of information on their life history aspects and their limited economic value. This work presents an overview of skates and rays inhabiting the marine Greek waters and reports biodiversity issues requiring resolution for conservation purposes. Overall, 30 species from nine families and 16 genera have been documented within the past 22 years, based on the available literature and technical reports from research surveys of the Hellenic Centre for Marine Research (HCMR). However, 28 species are currently confirmed, since the presence of two rajids has not been sufficiently demonstrated and hence is considered as doubtful. Recent changes in nomenclature allowed us to replace old with new names in four species on the Greek list; patterns in the frequency of occurrence were observed and species were assigned into five categories; and diversity and misidentification issues were reported by family. Although Greek waters are oligotrophic and not considered a biodiversity hot spot for elasmobranchs, a high number of batoid species is documented in the area; therefore, the need to reinforce knowledge on biological aspects of skates and rays, define their status and identify their main threats is essential.
Follow-Up Infarct Volume Prediction by CTP-Based Hypoperfusion Index, and the Discrepancy between Small Follow-Up Infarct Volume and Poor Functional Outcome—A Multicenter Study
Authors: Zhou Pengyu , Li Ran , Liu Siyun , Wang Jincheng , Huang Lixiang , Song Bin , Tang Xiaoqiang , Chen Boyu , Yang Haiting , Zhu Chengcheng , Malhotra Ajay , Wang Yuting
Published: January 2023

(1) Background: Follow-up infarct volume (FIV) may have implications for prognostication in acute ischemic stroke patients. Factors predicting the discrepancy between FIV and 90-day outcomes are poorly understood. We aimed to develop a comprehensive predictive model of FIV and explore factors associated with the discrepancy. (2) Methods: Patients with acute anterior circulation large vessel occlusion were included. Baseline clinical and CT features were extracted and analyzed, including the CTP-based hypoperfusion index (HI) and the NCCT-based e-ASPECT, measured by automated software. FIV was assessed on follow-up NCCT at 3–7 days. Multiple linear regression was used to construct the predictive model. Subgroup analysis was performed to explore factors associated with poor outcomes (90-mRS scores 3–6) in small FIV (<70 mL). (3) Results: There were 170 patients included. Baseline e-ASPECT, infarct core volume, hypoperfusion volume, HI, baseline international normalized ratio, and successful recanalization were associated with FIV and included in constructing the predictive model. Baseline NIHSS, baseline hypertension, stroke history, and current tobacco use were associated with poor outcomes in small FIV. (4) Conclusions: A comprehensive predictive model (including HI) of FIV was constructed. We also emphasized the importance of hypertension and smoking status at baseline for the functional outcomes in patients with a small FIV.
Petrology, Mineralogy, and Geochemical Characterization of Paleogene Oil Shales of the Youganwo Formation in the Maoming Basin, Southern China: Implication for Source Rock Evaluation, Provenance, Paleoweathering and Maturity
Authors: Hu Fei , Meng Qingtao , Liu Zhaojun , Xu Chuan , Zhang Xun
Published: January 2023

Oil shale is a crucial unconventional energy source to supplement conventional oil and gas. The oil shale in the Maoming Basin of China has excellent resource potential. In this study, through systematic geochemical testing, the industrial quality and geochemical characteristics of oil shale are revealed, and the hydrocarbon generation potential of oil shale, the parent rock type, and the tectonic setting of the source area are discussed. It is comprehensively assessed that Maoming oil shale has a medium-oil yield (avg. 6.71%) with high ash content (avg. 76.1%), a high calorific value (avg. 7.16 M J/kg), and ultra-low sulfur (avg. 0.54%). The mineralogical compositions primarily consist of clay minerals and quartz, and barely pyrite. Maoming oil shale is in an immature evolution stage, with high TOC and I-II1 kerogen type, and could be considered an excellent hydrocarbon source rock. The chemical index of alteration (CIA), the index of chemical variability (ICV), and the Th/U ratio indicate that the Maoming oil shale parent rock area is strongly weathered. Multitudinous geochemical diagrams also show that the oil shale was mainly derived from Late Cretaceous felsic volcanic rock and the granite zone, and the tectonic setting was a continental island arc environment related to the active continental margin. This is consistent with the tectonic history of southern China in the Late Cretaceous.
Mixedness and Intersectionality: The Use of Relief Maps to Understand the Experiences of Multiracial Women of African Descent in Spain
Authors: Habimana-Jordana Teresa , Rodríguez-García Dan
Published: January 2023

This article analyzes the experiences of multiracial women of African descent in Catalonia, Spain—looking at their identity processes, social relations, experiences of racialization and discrimination, and strategies of resistance—using a novel qualitative research method called “Relief Maps,” a very useful tool for the study of social inequalities from an intersectional and multilocational perspective. Relief Maps are a data collection tool and a means of visualizing and analyzing data—providing a graphical representation of interviewee narratives that discuss processes of social inclusion and exclusion. The maps represent three dimensions of experience: (1) psychological (indicating the respondent’s level of discomfort or well-being); (2) geographical (including at least five physical or experiential locations: e.g., home, street, work, school); and (3) social (examining seven social variables or aspects of identity: i.e., gender, ethnicity/skin color, age, sexual orientation, social class, physical appearance, and religion). In this way, the maps show where greater or lesser well-being or discomfort is experienced by the respondent based on each aspect of identity, thus indicating personal places of oppression, places of controversial intersections, neutral places, and places of relief. We argue that this supplementary investigative technique is highly relevant to research in the social sciences, particularly in the field of mixed-race, critical race, and ethnic studies, as it provides an intersectional, reflective, nuanced, and contextual lens for understanding complex social phenomena, leading to information of greater analytical strength.
Effects of Forced-Air Precooling on Postharvest Physiological and Storage Quality of Winged Beans
Authors: Lee Ying-Che , Hsu Min-Chi , Liao Jia-Zhu , Wei Zhao-Wei , Chung Hsin-Ying , Liang Yu-Shen
Published: January 2023

Winged beans accumulate abundant field heat following harvest, and their shelf life is shortened if precooling is not performed promptly. In the present study, top-suction forced-air precooling (FC) was employed to rapidly remove field heat from pods, and its effects on winged bean pod storage quality and shelf life were assessed. After postharvest FC to remove field heat from winged bean pods, the mean 1/2 precooling time was 5.8 min and 7/8 precooling time was 14.7 min, which was 9.6 times and 11.7 times faster than room cooling (RC), respectively. Moreover, after FC was applied to remove field heat, the weight loss rate at 7/8 precooling time was 0.92%, significantly lower than that after RC was applied (1.98%). FC could delay decay, and the decay rate was only 18% on day 14 storage, which was lower than 52% of RC. During 12 °C and 85% relative humidity (RH) storage, the shelf life of winged bean pods in the FC group was 14.8 days, which was significantly longer than that of the pods in the RC group (10.6 days). In conclusion, FC is an effective precooling method to rapidly remove field heat postharvest and maintain the storage quality of winged beans.
Hydroponic Agriculture and Microbial Safety of Vegetables: Promises, Challenges, and Solutions
Authors: Sela Saldinger Shlomo , Rodov Victor , Kenigsbuch David , Bar-Tal Asher
Published: January 2023

Hydroponics is a farming technique for growing plants with mineral nutrients using a soil-free medium. The plant roots are submerged in soil-free media, such as vermiculite or perlite, or just in mineral nutrient solutions. This allows for high production yields throughout the year with less water and agro-chemical inputs. Consequently, hydroponics is considered a sustainable agriculture technology. Hydroponically grown crops are usually protected from the diseases transmitted through soil or animals in open fields. Therefore, they require fewer chemicals for pest control and are safer than conventionally grown crops in terms of possible chemical contamination. Nevertheless, hydroponics guarantees neither plant health nor the microbial safety of fresh produce. In the case of microbial contamination by human pathogens, unlike soil-grown crops, the pathogens may rapidly spread through the circulating water and simultaneously infect all the plants in the facility. This review summarizes the up-to-date knowledge regarding the microbial safety of hydroponically grown crops and discusses the role of the hydroponic system in reducing the microbial hazards for leafy and fruity crops as well as the potential risks for contamination by human pathogens. Finally, it outlines the approaches and the available science-based practices to ensure produce safety. The contamination risk in hydroponic systems may be diminished by using novel planting materials and the appropriate decontamination treatment of a recirculating liquid substrate; by modulating the microbiota interactions; and by following strict phytosanitary measures and workers’ hygienic practices. There is a timely need to adopt measures, such as the Good Agricultural Practice (GAP) guidelines, to mitigate the risks and ensure safe hydroponically grown vegetables for consumers.
Identification of Genes of Molecular Marker TGS0892 on Chromosome 6 and Its Mechanism of Soluble Solids Metabolism in Tomato
Authors: Zhang Rong-Rong , Tao Jian-Ping , Song Liu-Xia , Zhang Jia-Qi , Liu Hui , Zhu Wei-Min , Zhao Tong-Min , Xiong Ai-Sheng
Published: January 2023

Tomato (Solanum lycopersicum L.) is one of the vegetables widely cultivated in the world, whose fruits are rich in nutrients. Soluble solids content (SSC) is one of the important factors affecting tomato fruit flavor and plays a decisive role in improving tomato quality. Molecular markers are genetic markers that reveal plant genetic polymorphism at the DNA level, which have the advantages of improving breeding purposes, increasing selection efficiency, and shortening breeding years. The molecular marker TGS0892 is located on chromosome 6 of the tomato genome and is closely related to soluble solids. In the present work, five different tomato cultivars were used as experimental materials. The results showed that ‘TD-10’ had the lightest single fruit weight and the highest soluble solids content, while ‘TD-8’ and ‘TD-9’ had heavier single fruit weight and lowered soluble solids content. Seventeen genes within 50 kb upstream and downstream of the molecular marker TGS0892 were identified using bioinformatics methods, and their structural analysis and functional annotation were performed. Quantitative reverse transcription PCR (RT-qPCR) showed that the expression levels of the 17 genes in different tomato cultivars were classified into two major categories, with the highest expression in ‘TD-7’ and other cultivars, respectively. Soly065970 and Soly066010 were significantly more expressed in high soluble solids tomato cultivars (‘TD-7’ and ‘TD-10’) and less expressed in the low soluble solids tomato cultivar (‘TD-9’). The results suggested that Soly065970 and Soly066010 may be involved in regulating the soluble solids metabolic process, which provides a reference for studying the formation mechanism of highly soluble solids in tomatoes.