bluuebunny/crossref_metadata_2025 huggingface dataset:
The characteristics of medical social state in patients with nose and perirhinal sinuses diseases associated with chlamidiae infecting
Authors: Parilova O. V. , Kapustina T. A. , Kin T. I.
Published: June 2020

There were presented the results of examination for 104 patiens with acute and chronic pathology of nose and perirhinal sinuses associated or not with chlamidiae infection involving medical social characteristics. The authors marked that the main place in the structure of medical social types of both chlamidae infected and non-infected patients belonged to medical and social risk subjects. But we observed the decreased health level in respondents with confirmed chlamidiae infection and comparatively higher range of negative social factors.
UBC-test use in the capacity of urinary marker of bladder cancer
Authors: Vintizenko S. I. , Slonimskaya Ye. M. , Usynin Ye. A. , Stukanov S. L.
Published: June 2020

The enzyme immunoassay was used to evaluate diagnostic value of level of tumoral marker UBC at 54 patients with muscle invasive bladder cancer. The obtained data testify to possibility of use of the UBC-test for diagnostics primary bladder cancer, at monitoring for patients for revealing superficial and muscle invasive relapses after spent treatments. UBC it can be considered as the additional diagnostic marker, allowing to assume presence muscle invasive character of growth of a tumors, and also for an efficiency estimation neoadjuvant chemotherapy.
Pharmacological correction of no-reflow phenomenon in myocardial infarction treatment
Authors: Mamonova T. Yu. , Markov V. A. , Udut V. V.
Published: June 2020

This article presents the research findings on the impact of carvedilol on the course of the necrosis myocardium focus and malone dialdegid concentration with patients, afflicted with acute myocardial infarction. The study proves that carvedilol slows down the necrosis focus formation and relieves the intensity of the no-reflow phenomenon as well as the oxydative stress, in case it is administered prior to the trombolytic therapy.
The threshold determination of the pulp electroexcitability of teeth in the persons with attendant somatic pathology
Authors: Lyubomirskiy G. B.
Published: June 2020

The research on 559 intact teeth has been conducted among 128 patients with different systemic pathology. It is established that in the patients with psycopathology diseases the threshold of the pulp excitability in molars decreases significantly, in the patients with the diseases of the cardiovascular system the electroexcitability of the pulp increases in the region of the same teeth, and in the patients with the pathology of connective tissue the pulp in the region of all teeth reacts to the power of current almost two times lower than in somatically healthy persons.
Ferrogem therapy of women with chronic hypochromic anemia
Authors: Makhmutkhodzhaev A. Sh. , Yevtushenko I. D.
Published: June 2020

The results of randomized clinical trial of the effectiveness of biologically active admixture «Ferrogem» therapy the women with moderate chronic anemia has been presented. The «Ferrogem» therapy within a four week resulted in complete relief of anemic syndrome, normalization of red blood quantitative and qualitative indices, restoration of reserves of iron.
Expression of steroid hormones receptors and morphofunctional condition endometrium at patients with anomalous uterine bleedings
Authors: Tayukina I. P. , Mustafina L. M. , Tikhonovskaya O. A. , Logvinov S. V.
Published: June 2020

The research of the influence of drug containing Indole-3-carbinol in combination with Kipferon on morphofunctional condition of endometrium with anomalous uterine bleedings is carried out. Ineffectiveness of hormonotherapy at pathological conditions of endometrium is specified by reduction of expression of estrogens and progesterone receptors. Suggested method is effective due to anti-inflammatory and receptocorrecting effect, and probably, is recommended in the case of simple hyperplasia in combination with chronic endometrium in the stage of preparing endometrium for hormonal therapy.
The role of cytokines in redox-dependent regulation of apoptosis
Authors: Chechina O. Ye. , Biktasova A. K. , Sazonova Ye. V. , Zhukova O. B. , Prokhorenko T. S. , Krat I. V. , Chasovskikh N. Yu. , Novitsky V. V. , Ryazantseva N. V.
Published: June 2020

Research of influence of recombinant tumor necrosis factor alpha, interleukin-2 and interleukin-4 in vitro on the apoptosis of lymphocytes is performed. It is revealed that a proapoptotic effect of these cytokines is dose-dependent and is realized with the assistance of reactive oxygen species and mitochondrias.
Psychosomatic disorders among women with climacteric syndrome during earlier postmenopause
Authors: Yelchaninov D. V. , Akker L. V. , Smagina I. V. , Gridina A. O.
Published: June 2020

Forty women with climacteric syndrome took part in a prospective research. Strong vegetative dysfunction and increased anxiety and light situational or neurotic type depression (30% patients) were found. Health related quality of life increased after correction of these disorders with Estrovel — product, containing combination of standardized medicinal herbs extracts.
The peculiarities of multiple sclerosis clinical course in the South of Russia (on the example of Rostov Region)
Authors: Goncharova Z. A.
Published: June 2020

In order to improve multiple sclerosis (MS) diagnosing and specify the influence of climatic and geographic factors on the clinical picture of the disease, the peculiarities of its course and clinical polymorphism in the population of Rostov region were studied. The analysis was conducted to compare the main characteristics of MS in Rostov Region (prevalence — 27,2 : 100 000 of its population) and the area with a considerably bigger rate (Novosibirsk — 54,36 : 100 000). The distinctive peculiarities of the disease among people living in the South of Russia (on the example of Rostov Region) are slow progression and wide clinical polymorphism.
Indicators of autonomic regulation of cardiovascular system subject in the acute phase of ischemic stroke with a favorable outcome
Authors: Kolokoltsev K. Ye. , Nazarenko N. V. , Kutkin V. M.
Published: June 2020

A new method of forecasting the outcome of ischemic stroke in the acute period, based on dynamic monitoring of new indicators of autonomic regulation of cardiovascular system — VIB (vegetative indicator of blood circulation), BSB (background systolic blood pressure), IDD (index of diastolic pressure). VIB allows to quantitatively assess the state of autonomic tone of the cardiovascular system, and to evaluate its dynamics, comparing with the physiological state of the patient. BSB — background systolic blood pressure, a quantitative method of assessing the standard systolic (pressor) load. IDD — an index of diastolic pressure — a way to assess the proportionality of hemodynamics. A retrospective analysis of 131 case histories of patients with ischemic stroke favorable outcome. The expression of VIB on admission and the normalization rate with the seriousness of the disease.
Considering the question about spinal liqiud's outflow to the lymphatic channel
Authors: Pesin Ya. M. , Omorov N. K. , Doronin B. M.
Published: June 2020

The interstitial fluid drains from the cerebral hemisphere to the same named deep neck's lymph nodes in perineural spaces. The spinal liquid drains from the subarahnoid spase to left and right neck area's lymph nodes.
Peculiarities in the course of chronic cerebral ischaemia in senior age groups in the dynamics of medical rehabilitation under conditions of a specialized medical center
Authors: Popova T. F. , Klimova L. A.
Published: June 2020

According to the data of the investigation it was established the connection between the intensity of neurological and cognitive disturbances, psychoemotional disturbances and changes of quality of life of the adult and elderly patients with chronicle cerebral ischemia. It was showed that using the rehabilitation therapy in the special referral medical center in the beginning stage of the disease bias for the better on quality of live of the patients.
Effect of the neurovegetative blockade on haemodinamic parameters and the course of acute period of stroke
Authors: Sycheva M. A. , Astrakov S. V. , Кuryachenko Yu. T. , Porotnikova N. A. , Oleksyuk N. V.
Published: June 2020

For the study of effect neurovegetative blockade of the brain on the course of an stroke in the acute period was carried out noninvasion monitoring of the basic parameters systems haemodinamic and a vegetative homeostasis with use of Kerdo Index at 110 patients with different types of stroke. The neurovegetative blockade having been started in the first day of the brain damage promotes the decrease of damaging reactions manifestations, normalization of vegetative homeostasis and promonting more favourable course of acute period stroke and its prognosis.
Demographic characteristics of patients with motor neuron disease subject to conditions of large industrial city in West Siberia
Authors: Lebedev A. V.
Published: June 2020

78 patients with motor neuron disease (MND) were examined. Prevalence of MND in urban population of Novosibirsk on 2008/01/01 is 3,46 per 100 000 of population. In majority of patients amyotrophic lateral sclerosis (ALS) was revealed — 76 people (97,4%); primary lateral sclerosis was revealed in 1 case (1,3%), progressive bulbar paralysis was revealed also in 1 case (1,3%). There were 63 men (80,8%) and 15 women (19,2%) (ratio is 4,2 : 1,0). There was no people younger than 27 years for the moment when first symptoms of the disease were revealed. The major age group was 41 to 60 years (66 people — 84,6%).
Spiritual dominant and ageing of organism
Authors: Troshin V. D.
Published: June 2020

The paper shows conception of integrative ageing of organism based upon complex approach and clinical-and-psychological, clinical-and-neurophysiological and neuroimmunological studies. Spiritual-and-psychic and genomic spheres of activity play major role in ageing and combine nervous, endocrine and immune systems. Controlling systems take part in pathological process that’s why there have to be integrative attitude with accent on spiritual-and-psychic and genomic spheres. Spiritual dominant in man’s life is the basis of health harmony and active longevity.
Hereditary muscular dystrophies
Authors: Doronin V. B. , Doronina O. B.
Published: June 2020

Precise diagnostic of hereditary muscular diseases begins to change during recent years due to genetic achievements. Genetic defects discoveries typical for different clinical variants of muscular dystrophies give opportunity for creation of specific testsystems to verify the diagnosis. Determination of gene and protein causes of neuromuscular pathology however does not exclude initial clinical diagnostic which cost less and easier to find.
Respective characteristic from vascular and degenerative mild cognitive impairments
Authors: Bugrova S. G.
Published: June 2020

42 patients with dyscirculatory encephalopathy (DE) and 42 patients with Alzheimer desease were investigated. From neurologycal and neuropsychologycal tests and multyspiral computer tomography and electroencephalography it was exposed that vascular mild cognitive impairments (MCI) have dysfunction from neuroregulation and leucoareosis and lacunar inpharcts and hydrocephalia. Alzheimer desease MCI have cortical brain atrophy.
Value of patology of the vestibular analyzer in pathogenesis impellent frustration in children with cerebral paralyses
Authors: Glukhov B. M.
Published: June 2020

Value of functions of the vestibular analyzer of the child in formation of its motility is shown. 11 patients aged till three years, suffering by a childrens cerebral paralysis, have been surveyed. Was studied the group of the tonic reflexes in dynamics, afferent arch of which was the vestibular mechanism and its conductors. Infringement of degree of expressiveness of tonic reflexes and their late reduction are a principal cause of formation of a pathological impellent stereotype at the child.
Some peculiarities of the social adaptation in patients with discectomia in distant period
Authors: Dorochova Ye. A. , Fedyanin S. A.
Published: June 2020

With purpose of studying of social adaptation in patients with pain syndrome recurrence in the discectomia distant period were 215 patients investigated. Study methods included neurological examination, magnetic resonance tomography, rentgenography, ultrasonography, Osverstry query. Reasons of pain syndrome recurrence were revealed. It was ascertain, that the pain syndrome recurrence is accompanied by social desadaptation. Participation of social specialists in adaptation process is recommended.
Magnetotherapy in the combined treatment of chronic opisthorchosis patients
Authors: Schegoleva S. F. , Poddubnaya O. A. , Beloborodova E. I. , Rekhtina S. D.
Published: June 2020

The development of new methods for treatment of chronic opisthorchosis patients is very urgent in regions hyperendemic in this disease. The use of phyto- (ecorsol) and physiotherapeutic (magnetotherapy) method in the combined therapy of this disease is promising and significant. These methods have the sufficient antihelminthic effect (up to 85,0%) and positively affect the indices of the motor-evacuation function of the biliary excretion system (1,2—1,3 times decreasing the volume of cystic bile and 1,7—2,1 times increasing indices of the contractile function of the gall bladder) and the level of adaptation capabilities of an organism (increasing the number of patients with the activation reaction by 16,7—33,4%).
Multiple-factor of metabolic disturbances at women of genesial age in a postovariectomy state
Authors: Pokul L. V. , Yevtushenko I. D. , Zhabina Ye. S.
Published: June 2020

In this article the postovariectomic syndrome is regarded as prediction of metabolic syndrome in women of different age groups. With various clinicodiagnostic analyses it has been estimated that in women with postovariectomic syndrome over 40 metabolic disturbances are observed more frequently.
Role of nitric oxide and cytoskeleton in regulation of contractile activity smooth muscle cells
Authors: Gusakova S. V. , Baskakov M. B. , Kovalev I. V. , Melnik O. S. , Kapilevich L. V. , Medvedev M. A. , Studnitsky V. B. , Antonov O. I.
Published: June 2020

The influence of modulation of cytoskeleton by colchicine, nocodazole and cytochalasine D on contractile reactions of smooth muscle cells caused by depolarization, phenylephrine end sodium nitroprusside has been investigated by the mechanographical method. It was found that the reduction in smooth muscle cells of rat aorta caused by fenilefrin more sensitive to sodium nitroprusside than the reduction induced hyperpotassium solution. We show that microtubules involved in relaxation, indirect nitric oxide of smooth muscle in hyperpotassium solution, whereas the efficiency of relaxing influence of nitric oxide in rat aorta smooth muscle in the action depends on phenylephrine and microfilaments and microtubules.
Morphological aspects used of semisynthetic antioxidant dibornol in treatment of rats OXYS with involutional central chorioretinal degeneration
Authors: Zhdankina A. A. , Plotnikov M. B. , Smoliyakova V. I. , Ivanov I. S. , Kolosova N. G. , Fursova A. Zh. , Kuchin A. V. , Chukicheva I. P. , Logvinov S. V.
Published: June 2020

Retina of rats OXYS 6 months of age by treatment of 4-methyl-2,6-diisobornylphenol (dibornol) was researched. Mainly, rats OXYS have of vascular disturbances such as reduction open functional vasculars of choroidea, destruction of retinal pigmental epithelium and retinal neurons. Dibornol was protected of retina increased area of open vascular and safety of retinal neurons. Besides dibornol was prevented thrombosis in retinal vasculars.
«Skin window» cytokines in atopic dermatitis
Authors: Zagreshenko D. S. , Klimov V. V. , Denisov A. A. , Salikova T. I. , Firsova Ye. K.
Published: June 2020

There have been defined IL-4, IL-10, IL-17 and IFN-γ in cell-free skin exudate in 90 patients of atopic dermatitis depending on spread of dermal pathological process. There been found that variations of each cytokine had different features and reflected different parts of immunopathogenesis of the disease both in an acute period and remission and after allergenspecific immunotherapy.
Biomechanic and physiological factors providing the technique of goal-oriented shot actions in football
Authors: Koshelskaya Ye. V. , Bazhenov V. N. , Buravel O. I. , Kapilevich L. V. , Andreyev V. I.
Published: June 2020

Biomechnic peculiarities of the technique of shots in football have been studied. With the aid of electromyography and stabilography, 45 men aged from 18 to 27 were examined. It has been shown that stabilographic and electromyographic characteristics of ball shooting can serve indicators of technical development of sportsmen. The technique of direct kick is formed at the stage of perfection of basic skills, while that of lateral kicks is formed at the stage of top sport mastering. In football players of high qualification, the role of the visual analyzer in equilibrium control is insignificant, while in low- and moderate-qualified players, the equilibrium function works worse without visual control.
State of vegetative regulation in endometriosis in women at reproductive age with anxiety and depressive disorders
Authors: Nasyrova R. F. , Sotnikova L. S. , Novitsky V. V. , Zhukova N. G. , Baikov A. N. , Krivoschyokova G. V.
Published: June 2020

Results of study of vegetative regulation in endometriosis have been presented in women at reproductive age with anxiety and depressive disorders. Obtained data demonstrate reinforcement of activation of central contour and growth of sympathic regulation in endometriosis in women with anxiety and depressive disorders what testifies to significant tension of regulator systems and critical state of adaptive mechanisms. Results of the investigation have allowed revealing the distinctive associations between psychopathological manifestations and vegetative disturbances in studied pathology.
Peculiarities of uretral pacemaker zones innervation
Authors: Tsukanov A. I. , Baitinger V. F.
Published: June 2020

Peculiarities of extra-intraorgan innervation of uretral pacemaker zones (upper and lower urethral narrowings) were investigated. Anatomic-histological investigation results showed that upper (the I order pacemaker) and middle (the II order pacemaker) pacemaker zones of the ureter are innervated by single nerve stems from lower aortic-renal ganglion of plexus nervosus. Presence of microganglia in their intramuscular plexus nervosus is the peculiarity of intraorgan innervations of uretral pacemaker zones. The data obtained contribute to cystoid-peristaltic theory of uretral motility organization.
The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients
Authors: Efendiyev A. M. , Azizova G. I. , Huseynova G. R.
Published: June 2020

We evaluated some biochemical and immune parameters, such as IgA, IgM, IgG, CIC, phagocytic index, T-lymphocytes, as well as avidity of antibodies in type 2 diabetic patients.

Avidity, high- and low-avid antibody ratio was determined by test-systems for express-diagnostics of clinical and preclinical forms of immunologic deficiency. All patients (n = 47), depending on the level of glycemia and disease duration were divided into 3 groups: in the stage of compensation, subcompensation and decompensation. Control group included 17 healthy subjects.

Value of high-avid antibodies in diabetes mellitus patients decreased in 75, 57 and 26% respectively, whereas in healthy subjects it is 89%. Conversely, increased amount of low-avid antibodies was observed, respectively 25, 43, and 74% (11% in control).

These parameters prove antibody-folding disorders in diabetes mellitus and show that, change of metabolic parameters affects antibody avidity: G class high-avid antibody level decreases and shows weak protective function. This indicates functional disorders in B-system immunity.
Using administrative databases for parmacoepidemiological monitoring of asthma drug prescribing
Authors: Karakulova Ye. V. , Zenkova Z. N. , Кlokova M. V.
Published: June 2020

Possibility of using administrative drug utilization database for pharmacoepidemiological monitoring is studied. The expediency of application ATC/DDD methodology for estimation tendencies in drug utilization in the system of preferential medicinal support is proved. It was determined more intensive use of combined asthma drug by patients of Tomsk, and oral corticosteroids and short-acting b2-agonists by patients from Tomsk region (without Tomsk).
Comparative estimation of domestic drugs Laifferon and Reaferon-ES antiviral treatment of the chronic viral hepatitis patients
Authors: Petrova Ye. I. , Chuikova K. I.
Published: June 2020

The paper presents the results of clinical tests of the comparative estimation of tolerance, effectiveness and clinic-laboratory indices of chronic HBV and HCV patients Laifferon and Reaferon-ES treatment within a year (12 month). Less collateral effect caused by laifferon is stated. The results of effectiveness of Laifferon and Reaferon-ES treatment of the chronic HBV and HCV patients did not differ in compared groups.
Analysis of conjugacy between treatment systems and the efficiency of combined treatment of patients with chronic cholecystitis in combination with chronic opisthorchosis
Authors: Poddubnaya O. A. , Kozhemyakin A. M.
Published: June 2020

In development of new treatment technologies, the reliability of results obtained should be beyond any doubts. The study of conjugacy of the obtained therapeutic effect with peculiarities of the combined treatment of patients with chronic cholecystitis in combination with chronic opistorhcosis and the revealing of predictors of the ultimate result are of great practical significance. The analysis of conjugacy tables and results of logistic regression, which allows one to determine prognostically significant signs (predictors) guaranteeing some or other result, favors the selection of the optimal treatment strategy for this category of patients.
Outside of easy display of chronic obstructive pulmonary disease: clinical and functional-morphological aspects of changes of intestines
Authors: Beloborodova E. I. , Akimova L. A. , Kritskaya N. G. , Asanova A. V. , Semenenko Ye. V.
Published: June 2020

At patients chronic obstructive pulmonary disease (COPD) average degree of gravity and heavy stages decrease absorption functions of a thin gut is established concerning fats, protein, carbohydrates, progressing with weight of disease, a degree of degenerate-dystrophic changes of a mucous membrane of a thin gut with its infringement regeneration potentialities. The received data are interpreted in a context of interrelation of function, structure of a mucous thin gut and a clinical component. Direct correlation communications between deficiency of weight of a body of patients COPD and decrease absorption functions of a thin gut in the attitude are established albuminum (r = 0,71), fats (r = 0,55), carbohydrates (r = 0,48).
Cellular cardiomyoplasty: state of the art and results of our investigation
Authors: Markov V. A. , Ryabov V. V. , Suslova T. Ye. , Poponina Yu. S. , Popov S. V. , Karpov R. S.
Published: June 2020

A modern representations and opportunities of cellular technologies in cardiology and cardio surgery are summarized in article. Results of the clinical researches concerning an opportunity of participation stem cells in regeneration of a myocardium are summarized and analyzed. Results of own clinical researches devoted to studying of bearableness, safety and efficiency of different ways of delivery autologous mononuclear bone marrow cells to the damaged myocardium in patient with acute myocardial infarction are submitted.
Regional features of endocrinological pathologies among trained youth of Tomsk and Tomsk Region
Authors: Alimbekova P. R. , Kravets Ye. B.
Published: June 2020

Health of youth, is substantially defined by social factors, a way of life, an ecological situation, volume and quality of rendered medical aid. Ten years' dynamics (1999—2008) parameters of health trained youth of Tomsk and Tomsk Region characterized: growth of prevalence endocrinological pathologies on 20,9%, primary desease — on 46,8%. All this causes at a regional level to study structures endocrinological illnesses in view of influence of anthropogenous factors for realization of monitoring endocrinological health of youth.
Absorptive function of the small intestine at chronic inflammatory bowel diseases
Authors: Burkovskaya V. A. , Beloborodova E. I. , Akimova L. A. , Naumova Ye. L. , Glinskaya O. N. , Markidonova A. A. , Kvach Ye. A. , Baksht A. Ye.
Published: June 2020

The absorption function of small intestine has been studied at chronic inflammatory intestine diseases anв assessed depending on the severity of the main process. In groups of patients with ulcerative colitis, Crohn’s disease, and irritable bowel syndrome, as well as in healthy persons, diurnal fat loss with feces was determined by the van de Kamer method, and the D-xylose tolerance test was performed. The disorder of nutrient absorption in patients with chronic inflammatory intestinal diseases is directly proportional to the severity of the main disease.
Functionally-morphological kidneys condition in patients with rheumatoid arthritis
Authors: Kalyuzhina M. I. , Bukharova Ye. O. , Shatuta A. Yu. , Kalyuzhina Ye. V. , Zibnitskaya L. I. , Yeliseyeva L. V.
Published: June 2020

The aim of the investigation was to study the functional-morphological state of kidney in patients with rheumatoid arthritis (RА). Examination was performed on 75 patients with RA and 25 healthy subjects. In addition to complete clinical and instrumental examination accepted in specialised clinic, biopsy of kidney was conducted. At 62 patients changes in an urinary deposit are taped. According to 25 nephrobiopsies in 12 cases took place mesangioproliferative variant of a chronic glomerulonephritis, the amyloidosis was detected at 5 patients, in 8 cases - vascular changes, the weak and moderate phenomena of a productive vasculitis of arterioles, the capillaries, accompanied by a focal perivascular sclerosis. Nephroprotective effect of basic therapy of RА was found.
Activity of kallikrein-kinin system in children in norm and at some pathological states
Authors: Kondratiyeva Ye. I. , Tropova T. Ye. , Sukhanova G. A. , Terentiyeva A. A. , Krivonogova T. S. , Gorev V. V. , Stepanenko N. P. , Tyuteva Ye. Yu.
Published: June 2020

Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions. We have studied the activity of kallikrein, kallikreinogen, angiotensine transforming enzyme, α1-protease inhibitor, and α2-macroglobulin in healthy children in different age periods, in newborns with hypoxic-ischemic encephalopathy, in children with infectious-inflammatory diseases of the urinary system, obesity, and metabolic syndrome.

The activity of the kallikrein-kinin system was increased in all the groups against the background of the decreased inhibitory activity of blood plasma of different intensity, which can be used for the prediction of the course of diseases.
Different age women’s quality of life characteristics depending on genital prolapse degree
Authors: Kokh L. I. , Dorosh T. N. , Kim S. K.
Published: June 2020

We studied the quality of life of 115 patients with different genital prolapse degree before operative treatment in age of 35—71 years. Questionnaires Short Form 36 Health Quality Survey for research of neuter were used. We ascertained that quality of life made worse in all extents of prolapse and that quality of life lower with age.
Audit of GINA (Global Initiative of Asthma) knowledge in primary care doctors of Tomsk regions
Authors: Abashina L. V. , Kobyakova O. S. , Deyev I. A. , Kolomeyets I. L. , Starovoitova Ye. A. , Cherevko N. A. , Petrovskaya Yu. A. , Nikitina L. Yu.
Published: June 2020

The one step study was aimed at assessing of GINA knowledge in primary care doctors. The results demonstrated that the primary care doctors most often use GINA (2006) as source of information. But some systematic problems were revealed. Among them there is shortage of primary care doctors knowledge about modern asthma treatment approaches and low level of diagnostic equipment in primary care.
Structure, chemical composition, and mechanic properties of bone tissue under the effect of natural zeolites and fluorine
Authors: Babenko O. A. , Gaidash A. A. , Bashirov R. S. , Yemeliyanov O. F. , Kovalyov A. A.
Published: June 2020

In the experiment with Wistar lab rats, the structure, physical-chemical properties, the strength characteristics of the bone tissue under the joint action of natural zeolites and sodium fluoride are investigated. Morphological studies were carried out with the aid of the atomic-force and scanning electron microscopy. Physical-chemical studies were carried out with the aid of the Raman spectroscopy and the atomic absorption spectrophotometry. Micromechnic tests were conducted by the microindentation method with the use of a micro hardness meter. It was shown that natural zeolites used as food additives and acting together with fluorine imposes an extreme impact on the bone tissue due to hypermineralization effect on membranes of bone canalicules with the secondary disorder of trophics of the bone matrix and the worsening of bone hardness characteristics. These circumstances cast doubt on promises of using zeolite and fluorine-containing medical drugs in osteoporosis correction technologies.
Characteristics of immunosuppression by viruses infections
Authors: Churina Ye. G. , Urazova O. I. , Novitsky V. V. , Naslednikova I. O. , Voronkova O. V. , Slepicheva N. R.
Published: June 2020

In the article is consider reasons of the second immunodeficiency, attendants flow the infectious diseases of viral kind. It is established, that molecular machinery make conditional viral-induce immunosuppression, in those number role in her forming CD4+ CD25+ T-lymphocytes, witch known as regulatory T-cells or T-reg, able expressed Foxp3 factor control transcription genes responsible for differentiation T-cells and secretion cytokins, participated in the suppression of immunity response.
Clinical and instruments criterias of the correction effectiveness in patients with chronic opisthorchosis of cholelithiasis
Authors: Korkin A. L.
Published: June 2020

To study influence of therapy Biltritsid and Ursosan on existence of cholelithiasis at opisthorchosis. Are inspected 87 patients with the cholelithiasis and chronic opisthorchosis. There were carried out in the investigating groups the analysis of the clinical, laboratory and instrument criterias of biliar and gastrointestinal disfunction. In patients with the cholelithiasis, in combination with opisthorchosis is revealed the low effect from conducting of litolithic therapy, which comprises not more than 20%. Conducting litolithic therapy after the preliminary antihelminthic therapy by Biltritsid makes it possible to achieve the significant litolithic effect, to the larger degree at the early stages of cholelithiasis, that composes 72,3% and 53,8% into 2 and 3 stages of cholelithiasis.
Efficiency of rehabilitation measures in reduction of perinatal morbidity
Authors: Krivonogova T. S. , Tropova T. Ye.
Published: June 2020

The clinical examination of 198 pregnant women after the health promotion program and their infants has been carried out. The content of stress hormones and the intensity of processes of lipid peroxidation have been studied, and adaptation abilities have been assessed. The use of the proposed rehabilitation program for pregnant women at early gestational ages favors the reduction of occurrence of feto-maternal disease and the increase of the adaptation reserve of women. Infants, whose mothers received the health promotional program, 3.5 times rarely had signs of the perinatal affection of the central nervous system.
Biomechanic characteristics of target-oriented kick motions in sportive karate
Authors: Bredikhina Yu. P. , Gouzhov F. I. , Kapilevich L. V. , Andreyev V. I.
Published: June 2020

The methods of electrmiography and stabilography are used to determine biomechanic characteristics of target-oriented kick motions in sportive karate. It is shown that highly qualified sportsmen can better maintain equilibrium in main karate combat maneuvers. This shows itself in the smaller amplitude of vibrations of the common center of gravity and in higher quality values of the equilibrium function compared to lower-qualification sportsmen. In addition, masters of sports show the synchronous operation of motor units, their simultaneous participation in a kick motion. The dynamics of main stabilogram and electromiogram characteristics can be used as an indicator of the level of technical training of sportsmen.
Carcinomatous pleuritis in women with malignant tumors of reproductive system: potentialities of a cytological technigue
Authors: Grigoruk O. G. , Lazarev A. F. , Bazulina L. M. , Chechulin M. N.
Published: June 2020

А cytological technique to determine the character of pleura pathology with malignant tumors among 297 women was used. The features of malignant cells of tumors of reproductive system in pleurisies with breast carcinoma (119), ovarian (73) and endometrial carcinoma (4) were studied. A light microscopy, also immunocytochemical technique with a set of 2—14 antibodies in difficult cases for diagnostics was used. With the dissemination of breast carcinoma on pleura, the specific pathogonomic characters in 78.2 % of cases are found. With ovarian carcinoma according to the certain cytological features also taking into consideration immunocytological characters in 34, 2% of observations, the site of primary tumor was exactly revealed. Indirect characters were noticed in 61, 6% of cases. With endometrial carcinoma, the special specific characters were not observed. Immunocytochemical technique can play a critical role in a differential diagnose of canceromatous pleurisies.
Clinical-functional peculiarities in the course of bronchial asthma in combination with the hypertonic disease
Authors: Zaripova T. A. , Antipova I. I. , Smirnova I. N. , Lyapunova I. Yu.
Published: June 2020

Clinical-functional peculiarities of bronchial asthma combined with the hypertonic disease have been revealed. It has been found that the combined pathology occurs more often in older age and proceeds with more pronounced clinical symptoms. It is characterized by the disturbed lipid exchange, diastolic disfunction, changes in the vegetative regulation of the cardiac activity. These symptoms should be taken into account in the plan of treatment.
Hydrogen peroxide influence on contractile activity smooth muscle cells: the role of cytoskeleton
Authors: Kovalyev I. V. , Gusakova S. V. , Melnik O. S. , Baskakov M. B. , Kapilevich L. V. , Medvedev M. A. , Studnitsky V. B. , Antonov O. I.
Published: June 2020

The influence of of hydrogen peroxide on the contractile reactions of smooth muscle cells caused by hyperpotassium solution end phenylephrine in modulation a potassium conductance the membrane and the state of cytoskeleton elements has been investigated by the mechanographical method. It has multidirectional influence of hydrogen peroxide in the reduction of smooth muscles of rat aorta with the membrane depolarization hyperpotassium solution and action phenylephrine: phenylephrine decline in value and increase strength hyperpotassium contractures. We show that the cytoskeleton components involved in the mechanisms of action of hydrogen peroxide in the contractile reactions of smooth muscles of rat aorta caused by phenylephrine.
The features of pathophisiology Helicobacter pilory associated ulceractive disease from the Khakasses
Authors: Ageyeva Ye. S. , Shtygasheva O. V. , Ryazntseva N. V.
Published: June 2020

Peculiarities of pathogene sis of Helicobacter pylori (HP)-associated gastric ulcer (GU) in Khakas se s are investigated. It is found that, in con - trast to Caucasian s, the activation of the Т-cell and humoral parts of the immune response in Mongoloids with GU is accompanied by the high con - tent of CD4 +- and CD20 +-lympho cytes in the muscou s coat of stomach. Changes revealed in the peripheral blood in GU patients were character - ized by a decrease in the magnitude of CD4 +- and CD8 +-lympho cyte subpopulations compared to patients with chronic gastritis. The detected pos - itive correlation between the АА-251 genotype of interleukin-8 and the risk of GU development in Khakssses indicated in favor of the existence of immuno-genetic regularities of GU development. The reasonability of determining population risk and protective genotypes of development of HРassociated GU in Khakasses is discussed.
The experimental basis for the effectiveness of the wound adsorbing bandage based on nanostructural graphite
Authors: Ryazantseva N. V. , Khandorin G. P. , Khasanov O. L. , Dubov G. I. , Shteinle A. V. , Mazin V. I. , Shteinle L. A. , Chechina O. Ye. , Ratkin A. V.
Published: June 2020

The infectious complications of injuries and wounds are the actual problem of surgery. One of the most important tasks for today is the investigation of new remedies to prevent from the infectious process and to accelerate purifying processes from necrotic tissues in the wound and to intensify the wound regeneration. In this connection, to guarantee sorbing, antimicrobic, necrolitic and anesthetic protective actions is necessary to develop the first stage wound process bandage. As a result of the doctors’ and scientists’ team-work investigation a new dressing model for treating exuding wounds has been made. In the experiment this adsorbing bandage with the sorption level based on graphite particles (thermo broadened form of fluorinated graphite intercalated compound) has shown the high wound healing and drainage activity in treating associated gunshot bone-arterial injuries of extremities.
Strategies for control achievement in the real clinical practice settings. The data of ARROW-ACT study
Authors: Kulikov Ye. S.
Published: June 2020

At multicenter prospective observational study conducted in 19 centers in Russia under common protocol (n = 543) was demonstrated that in the context of real clinical practice the use of a step-up treatment regime and long-term dosing in a stable volume leads to control achievement in 73,3 and 69,4% cases respectively.
Modern look at pathogenetic mechanisms of joint disease in patients with ixodic tick-borne borreliosis
Authors: Reshetova G. G. , Shvtsova O. V.
Published: June 2020

The modern look at pathogenetic mechanisms of joint disease in patients with exodic tick-borne borreliosis is presented. The problems of etiology, pathogenesis, classifications, and morphological peculiarities of Lyme-arthritis and mechanisms of development of immune inflammation are considered.
The principles of patients protection from noncardiac complications in cardiac and vascular surgery
Authors: Loyenko V. B. , Sorokina Ye. A. , Morova N. A. , Smyalovsky V. E. , Gubenko A. V.
Published: June 2020

The generalized information in area of noncardiac complications prevention are introduced based on results of own researches and literature data (prevention of ischemic stroke, gastroduodenal bleeding and infectious complications in cardiovascular surgery): preparing of patient for planning surgical intervention, including finding of stenosing and/or embolodangerous plaques and theirs surgical treatment; diagnosis of gastroduodenal erosions and ulcers, theirs epitelization and etiologic treatment; diagnosis and sanation of infectious focuses; using of surgical methods of cerebral protection (puncture intravasal grafting, intravasal filters) and pharmacologic cerebroprotection (nimodipine, vinpocetine) in operations on the brachiocefal artheries; two-step using of proton pump inhibitors more than three weeks duration in patients in groups of risk of gastroduodenal bleeding; prevention of infectious complications using three antibacterial drugs (cefalosporine of the third generation, rifampicine and fluconasole) mainly in cardiac surgery with on-pump circulation. Using the suggested arrangements, according our research data and results of investigations, fulfilled in other scientific centers, lets fundamentally decrease the frequency of aforenamed complications and increase the surviving of patients after cardiac and vascular surgery.
The traits of conservative correction of congenital clubfoot at the children of the first year old
Authors: Chuguy Ye. V. , Melnik D. D.
Published: June 2020

On the grounds of analysis results of the congenital clubfoot’s treatments 120 children of the first year old the indications and contraindications to correction of the deformation by the soft redressmentory bandage were determinated, the particularities of their using were distinguished. The designed method raises the good results of the conservative treatment of the disease more then on 30% in contrast with the traditional methods. The efficiency correction of the congenital clubfoot by the soft bandage straightly depends on observance particularities of the repair of the deformation by the offered way.
Medical economic efficiency of various schemes of rehabilitation of children with chronic gastroduodenitis
Authors: Shakhova A. M. , Lobanov Yu. F.
Published: June 2020

Medical economic efficiency of various schemes of rehabilitation of 120 children with chronic gastroduodenitis is studied. The Most economic scheme of rehabilitation of children with chronic gastroduodenitis is the scheme with use of training of children in gastroschool. Sanatorium treatment considerably raises mediko-economic efficiency of rehabilitation actions.
Optical properties of solutions of nanopowders magnetite and stanum dioxide
Authors: Zaitseva T. N. , Nosarev A. V. , Ageyev B. G. , Kapilevich L. V. , Diyakova Ye. Yu. , Magayeva A. A. , Terekhova O. G. , Itin V. I.
Published: June 2020

Optimal concentrations of the magnetite and stanum dioxide nanopowders for production of a stable aerosol are determined. The dependence of laser radiation absorption by the aerosol on the nanomaterial concentration in the initial solution is revealed.
Chronograph-2010
Authors: Kolomijceva O. V.
Published: June 2020

Chronograph-2010.
State evaluation of the oral cavity microflora based on Laser optical-acoustic spectroscopy
Authors: Bochkaryova O. P. , Kistenyov Yu. V. , Krasnozhyonov Ye. P. , Mushtovatova L. S. , Nikotin Ye. S. , Popova N. O. , Fokin V. A.
Published: June 2020

Owing to shortcomings of existing methods of evaluation of oral cavity microflora, reviewed possibilities for this purpose of new noninvasive method — laser optical-acoustic spectroscopy. The results show perspectivities of this method for diagnosis of microflora disorders.
The istant changes of the salivary glands to stress
Authors: Gerasimov A. V. , Logvinov S. V. , Kostyuchenko V. P.
Published: June 2020

Night lighting and microwave exposure have been influence on structures of stress realization. The endocrine, fotoperiodical and adaptive functions of rodent submandibular salivary glands belonging to hormone produced duct cells. To evaluate their morphofunctional state at guinea-pigs and rats using the methods of light and electron microscopy there have been analyzed striated and granular ducts. It has been revealed that instant and twenty-four-hour strengthening of duct cell stress induced secretory activity was similar. It is concluded that salivary glands take part in circadian expectations to stress.
Clinical morphological estimation of the apical granulom before treatment chronic periodontitis in the aggravation and remission stage
Authors: Semennikova N. V. , Logvinov S. V. , Semennikov V. I.
Published: June 2020

Tissues of apical granulomas at the exacerbation and remission stages before and after the treatment with the use of transcanal electrogranulotomy (TCEGT) have been studied by the methods of histological and clinical X-ray investigations and nonparametric statistics. The content of polymorphonuclear leukocytes at the exacerbation doubled compared to the remission (p < 0,05). After the treatment at the exacerbation stage (87 teeth) and beyond it (116 teeth), the activation of macrophages and fibroblasts was observed, as well as the appearance of Malassez's epithelial rests. The reconstruction of the bone structure has been found by the X-ray investigation in 97,6% of patients in the period up to 5 years. The treatment of granulomatous periodontitis with TCEGT is possible at any stage.
Interrelation of the maintenance endotehelin 1-21 in serum of blood and indicators of daily monitoring of arterial pressure with diabetic nephropathy in children and the teenagers of diabetes mellitus type 1
Authors: Enert A. V. , Ivanov S. N. , Samoilova Yu. G.
Published: June 2020

Daily monitoring arterial pressure (DMAP) and definition endotehelin 1-21 immunofermentat a method was perfermed in 79 children and teenagers with type 1 diabetes mellitus (DM1) in the age 10—18 years, with duration of disease 2—16 years auskultative a method on the apparate “Shiller BR-102 plus” (Switzerland). Depending on a degree of expressiveness diabetic nephropathy (DN) patients have been distributed on three groups: 1st — normalalbuminuria (n = 31), 2nd — microalbumiuria (n = 32), 3rd — proteinuria (n = 16) and 16 person the control group comparable on a floor and age. At children and teenagers with DM1 according to DMAP, attributes of a labile arterial hypertension (AH), met at 34,1%, stable at 25,5%. Frequency of revealing of stable forms АГ depend on expressiveness DN. The daily rhythm the AP at patients DM1 was characterized by a low degree of night decrease the AP. 47,1% patients 1st groups, 72,7% patients 2nd and 75% patients 3rd had no adequate decrease the AP at night. Communication between the raised level endotehelin 1-21 with development and progressing diabetic nephropathy, and also with indicators diastolic AP is revealed.
From ligature treatment to reconstructive angiosurgery (to 250th anniversary of vessel suture)
Authors: Shteinle A. V.
Published: June 2020

The historical review of the treatment of the injuries of the main arteries has been carried out by the author from the XVII century to the our time. The prime stages of the formations of the reconstructive surgery of the arteries have been shown.
The magnetic-laser therapy in the system treatment of anemia in pregnant women infected with Helicobacter pylori
Authors: Aristova I. V. , Yuriyev S. Yu. , Barabash L. V. , Krotov S. A.
Published: June 2020

The article is presented with the results of comparing assessment of clinical efficiency of the magnetic-laser therapy in doublefrequency ranges (150 ang 1 500 Hz) combined with iron therapy (sorbifer 100 mg once a day) in treatment of benign anemia of pregnancy, running above with the chronic gastritis, associated with contamination of gastrointestinal tract by Helicobacter pylori. The results of treatment show that the clinical effect is optimal for noninvasive magnetic-laser impact on blood with 150 Hz frequency. This method allows to raise hemoglobin while maintaining the iron depot in the form of ferritin together with cutting off the infectious process on the gastrointestinal tract mucous.