bluuebunny/crossref_metadata_2025 huggingface dataset:
De la philosophie heideggérienne de la religion à une philosophie de la présence comme spiritualité
Authors:   Université Félix HOUPHOUËT-BOIGNY (Côte d’Ivoire), YAPO Séverin
Published: February 2025

La religion introduit à la spiritualité. La notion de « présence » permet de caractériser toute religion introduisant à la spiritualité. Cette réflexion relative au dialogue entre la philosophie de la religion et la pratique de la spiritualité s’appuie sur la critique de la philosophie de Heidegger quant à sa puissance de relier à la présence. Ses traits généraux constituent le corpus de la recherche. Son analyse montre que la philosophie n’est pas toujours explicite sur son potentiel spirituel. Ce potentiel y apparaît dans un mouvement double : dévoiler la relation de l’homme soit à la présence, soit au théologique. Les questions de relation, de divins, d’absence, et de présence sont autant d’éléments qui déterminent le potentiel spirituel d’une philosophie. Notre recherche a ainsi exploré les marqueurs de cette spiritualité.
Public policy and governance under Imran Khan: A critical assessment
Authors: Shah Prof. Dr. Zahir , Iqbal Javed
Published: February 2025

This article critically examines public policy and governance under Imran Khan's leadership as Prime Minister of Pakistan (2018–2022). It examines the efforts of his government to combat economic instability, corruption, social injustice, and education reform and re-make foreign policy. Structural economic reforms to improve ease of doing business, ambitious social welfare programs like the Ehsaas and Sehat Sahulat initiatives, and education standardization through the Single National Curriculum were the major reforms. The administration's achievements, such as the improvement in world business rankings and more social protection programs, and the recurrent issues of higher inflation, bureaucratic inefficiencies, and selective anti-corruption were the findings of the research. In addition, the foreign policy realignments with China and Russia and strain with Western allies posed questions regarding strategic coherence. Based on a qualitative analysis of secondary data from government reports, scholarly research, and international assessments, the article examines the achievements and failures of such governance efforts. The article concludes that although the policy vision of Khan was reformist, practical implementation was overcome by institutional resistance and economic turmoil. The article urges inclusive, holistic governance efforts to promote sustainable socio-economic growth in Pakistan.
DEVELOPMENT OF ADVANCED MICROWAVE ABSORBING MATERIALS FOR ELECTROMAGNETIC INTERFERENCE (EMI) SHIELDING IN NEXT-GENERATION ELECTRONIC SYSTEMS
Authors: Saddam Hussain  , Madiha Liaquat  , Zamin Abbas
Published: February 2025

The growing use of portable electronic equipment and wireless communication systems has amplified the issue of electromagnetic interference (EMI), thus the need to design high-performance microwave absorbing materials. That is why traditional metal based shielding materials are good conductors but they include high density, corrosion and poor fatigue resistance and are rigid in nature. This work investigates the fabrication and EMI shielding characteristics of graphene, CNTs, MXenes, and the polymer-ferrite composites based on electrical conductivity, dielectric constant, mechanical strength, and thermal stability. In the case of shielding effectiveness, the MXene composites afforded 52.4 dB which is much higher than for graphene (42.1 dB) and CNT-polymer composites (39.2 dB) because of its higher conductivity and efficient absorption properties. In comparison to the commercial shielding materials, it was realized that these composites provided propitious performance enhancement in flexibility and considerably low weight. The results indicate that coating with MXene can integrate excellent properties with polymers to be the most potential candidates for the next-generation EMI shielding applications especially for 5G, IoT, aerospace, and wearable electronics. Additional research directions include improving large scale fabrication technology, combining carbon nanostructures, and discovering environmentally friendly shielding materials.
Green Finance and ESG Investment Strategies under Climate Risk Management
Authors: Zhang Ruyi
Published: February 2025

The growing danger of climate change leads to a rising need for green financial solutions and environmental investment that aids Sustainable Development Goals. Researchers study the development of green finance with ESG investing through climate risk management strategies, particularly to understand their effect on financial risk reduction. Environmental sustainability drives sustainable economic transformation through green finance that distributes funds to sustainable projects with the support of financial incentives and policy guidance. Financial markets benefit from ESG investing by obtaining competitive returns and end up supporting green corporate behavior. Green finance operations need rigorous macroprudential policies together with accurate national governance structures to maintain stability in the financial system. The study examines the influence of physical risks and transition risks linked to climate change on financial stability. These financial threats produce concrete economic results, which such instruments as green bonds and ESG indices can help determine. The paper aims to supply government officials with theoretical guidance and specific recommendations about promoting healthy growth of green finance and ESG investments throughout climate risk management complexities.
Study on the Interactive Design of Public Guidance Systems Based on the Design Thinking Behavior Model
Authors: Shengxuan  Zhang  , Zainudin Bin Siran  , Hew Soon Hin  , Na Zhang
Published: February 2025

This study explores the interactive design of public guidance systems based on the Design Thinking Behavior Model (DTBM). By analyzing user behaviors and thought processes, the research aims to optimize the design of public guidance systems to enhance user experience and system efficiency. Using Changsha Subway in China as a case study, the study identifies existing problems in the guidance system and proposes optimization strategies. The findings indicate that the DTBM can effectively improve the functionality and usability of public guidance systems, providing theoretical support and practical references for the development of smart cities.
Les facteurs ayant facilité l’intervention sociale auprès de sinistrés lors des inondations de 2019 : point de vue de gestionnaires et d’intervenants sociaux
Authors: Maltais Danielle , Hamel Ariane , Lansard Anne-Lise
Published: February 2025

Au printemps 2019, des inondations historiques ont affecté plus de 300 municipalités québécoises, forçant l’évacuation de milliers de résidents avec l’aide de centaines d’intervenants sociaux et municipaux. Cet article présente les résultats d’une étude qualitative s’intéressant aux points de vue d’intervenants sociaux et de gestionnaires oeuvrant au sein des CISSS, des CIUSSS ou des municipalités quant aux facteurs ayant facilité l’intervention sociale auprès de sinistrés lors de ces inondations. Lors de 20 rencontres de groupe focalisé, ces professionnels ont identifié quatre grands types de facteurs, à savoir ceux reliés à la société, aux organisations, aux intervenants et aux citoyens sinistrés.
Travailler dans un organisme communautaire et accompagner un parent d’enfant placé : quelles pratiques sont privilégiées ?
Authors: Pelletier Émilie , Ross Frédérike , Noël Julie , Ummel Deborah
Published: February 2025

Bien que peu documentées dans les écrits empiriques actuels, les interventions prodiguées par les personnes intervenant en milieu communautaire sont incontournables dans l’accompagnement des parents lorsqu’un enfant est placé par la Direction de la protection de la jeunesse. S’appuyant sur 28 entrevues individuelles semi-structurées, réalisées auprès de personnes travaillant au sein d’organismes communautaires du Québec, l’article présente leurs pratiques quant à l’accompagnement de parents au cours du processus de placement. Leurs propositions portent sur les habiletés au fondement de la création et du maintien du lien de confiance, sur la mise en valeur de l’évaluation globale de la situation du parent ainsi que sur les connaissances nécessaires pour soutenir la diversité des interventions requises. Le milieu communautaire, du fait de sa nature, met en place des pratiques novatrices et complémentaires au travail de la protection de la jeunesse. Ainsi, lorsque le parent le consent, la mise en place d’une collaboration intersectorielle apparaît essentielle pour que les parents d’un enfant placé par la Direction de la protection de la jeunesse puissent bénéficier de suivis cohérents et d’un continuum de services. Toutefois, pour que ces espaces de collaboration se matérialisent, l’expertise des personnes qui interviennent en milieu communautaire doit être reconnue.
« Dis-moi tout ce que tu sais sur… »
Authors: Wiertz Christine , Galand Benoît , Colognesi Stéphane
Published: February 2025

Notre recherche se concentre sur la compétence de résumé oral et la conduite
discursive descriptive chez les élèves de fin de primaire. Nous avons examiné (1) le niveau
d’aisance des élèves lors du résumé oral, (2) les changements observés lorsqu’ils ont refait
la tâche, et (3) les modifications apportées avec un appui documentaire. Vingt-quatre élèves
ont spontanément réalisé deux versions d’un même résumé, certains bénéficiant d’un support
écrit. Les analyses quantitative et qualitative révèlent que (1) la structuration du résumé
pose des difficultés, (2) réoraliser sans intervention n
’
améliore pas les
performances, et (3) l’appui documentaire n’engendre pas d’amélioration
significative.
Cishétéronormativité scolaire et jeunes queers : les limites d’un discours d’inclusion scolaire et de lutte aux LGBTphobies
Authors: Richard Gabrielle
Published: February 2025

Les enquêtes dont la France dispose pour dresser le portrait des conditions de scolarité de ses élèves queers sont peu nombreuses et limitées sur le plan méthodologique. Pourtant, des événements d’actualité récents ont contribué à faire que l’Éducation nationale mette en place des initiatives de « lutte aux LGBTphobies » pour favoriser l’inclusion des élèves minoritaires sur les plans de l’orientation sexuelle ou de l’identité de genre. À partir de deux enquêtes menées auprès de jeunes queers scolarisé·e·s en France, cet article met en évidence l’impasse de cette conception de l’inclusion scolaire selon laquelle le « problème à régler » est celui de conflits isolés entre jeunes, plutôt que des oppressions systémiques et cishétéronormatives que le système scolaire contribue à alimenter. Il présente la pédagogie critique des normes comme approche privilégiée pour considérer l’institution scolaire comme véhiculant elle-même des normes de genre et de sexualité qui constituent les leviers de l’exclusion des jeunes queers qui la fréquentent.
Les jeunes, Internet et leur argent : vulnérabilités et inégalités. Une approche par le risque sociodémographique cumulé
Authors: Henchoz Caroline , Mantzouranis-Baudat Sophie
Published: February 2025

De plus en plus d’activités financières se font par le biais d’Internet. Selon nombre d’études, les jeunes, les femmes et les plus précaires y recourent moins, ce qui peut conduire à de nouvelles formes d’inégalité. Ces études ne permettent toutefois pas de vérifier si les jeunes qui réunissent plusieurs facteurs de risque sont, comparativement aux autres, plus concernés par ces inégalités, car elles examinent les caractéristiques sociodémographiques de manière indépendante. L’approche du risque cumulé que nous mobilisons pour analyser les données 2019 de l’enquête Omnibus de l’Office fédéral de la statistique suisse remédie à cette lacune. Elle nuance le constat d’une fracture numérique. Certes, il existe des inégalités en matière d’inclusion financière numérique et de pratiques économiques numériques effectuées, les 18-29 ans les plus vulnérables étant moins susceptibles de mobiliser Internet pour gérer et dépenser leur argent. Cependant, il n’y a pas de liens statistiquement significatifs entre le fait de cumuler les risques et les activités de recherche de gains en ligne, ce qui laisse supposer que le numérique est aussi une ressource pour les plus vulnérables. On n’observe également pas de différence dans les problèmes rencontrés sur Internet et, le cas échéant, les pertes financières en découlant, ce qui semble indiquer des stratégies d’autocontrôle et des compétences dans l’évaluation des risques chez les plus vulnérables qu’il reste à explorer.
Improving Codon Evolution Models Using Complex Mutation Models
Authors: Hewgley Preston
Published: February 2025

This paper discusses an improvement in a Stochastic Evolutionary Model of Protein Production Rate (SEMPPR) by revising the method by which it models mutation. SEMPPR previously assumed unbiased mutation, an assumption whose inaccuracy is made clear by observed codon counts of low-expression genes, where mutation determines equilibrium state. This paper presents a new, more complex model generalized on a per-codon basis and calculated from observed codon frequencies using a maximum likelihood framework. Results obtained from SEMPPR using the codon specific mutation model proved more accurate in predicting a protein’s production rate, reaffirming that complex mechanisms govern codon mutation rates.
An Interview with Dr. Taylor Eighmy
Authors: Russell Sarah
Published: February 2025

The University of Tennessee welcomed Dr. Taylor Eighmy in October of 2012 as the new Vice Chancellor for Research and Engagement. Dr. Eighmy comes with many years of experience working to develop research initiatives, grants, and contracts for university research, having previously worked at Texas Tech University and the University of New Hampshire. In an interview on January 22, 2013, he discussed the importance of research at public universities, his personal experiences with research, and his goals for research development at the University of Tennessee.
New Age Insights: Filipino Millennials in Government
Authors:   Graduate School, Samar State University, Catbalogan City, 6700, Philippines, Chua Mark Kevin C. , Labid Sherrie Ann C. ,   Graduate School, Samar State University, Catbalogan City, 6700, Philippines, Bolante Lovely Rose A. ,   Office of the Executive Director for Research, Samar State University, Catbalogan City, 6700, Philippines
Published: February 2025

Millennials comprise a significant portion of the demography of the current Philippine workforce. Cognizant of the unique socio-cultural environment that shaped the Generation Y cohort, this descriptive phenomenological qualitative study aimed to explore millennial employees' work expectations and experiences within a government agency in the Philippines. Four themes emerged from the in-depth analysis of the five employees' interview responses: (1) job security and financial stability, (2) socio-emotional support, (3) fulfillment, and (4) professional development opportunities. The qualitative findings of this study emphasize the importance of supporting millennial employees' career growth and fostering a healthy work environment. It indicates that millennial employees know their value in government service and recognize that job security substantially impacts their performance. The findings of this study provide valuable insights into the work expectations and experiences of millennial employees in a government agency, highlighting the need for institutions to understand and adapt to the unique needs of this generation to foster a productive and engaged workforce.
Kids for a Happy Marriage? A Preliminary Study on Marriage Satisfaction and Presence or Absence of Children Among Married Individuals in Indonesia
Authors:   Faculty of Psychology, Universitas Pelita Harapan, 15810 Banten, Indonesia, Hutabarat Alftisya Victory , Himawan Karel Karsten ,   Faculty of Psychology, Universitas Pelita Harapan, 15810 Banten, Indonesia
Published: February 2025

Having children after marriage tends to be seen as a normative practice in Indonesia. As a result, individuals who do not have children could be at risk of experiencing a set of social stigmas. The study aims to explore whether having children is associated with one’s marital satisfaction. In particular, the present study aims to explore the differences in marital satisfaction among married individuals who have biological children, who are childfree (voluntarily childless), and who are childless (involuntarily childless). A cross-sectional survey was conducted to 210 married individuals (M age = 34.3; SD = 7.9). The result shows that child ownership is not the predominant determinant of marital satisfaction. The results of this study may pave the way and inspire further research in examining the unique psychological and social dynamics of child-free individuals, which are an understudied phenomenon in Indonesia.
The Strategy of Taman Mini Indonesia Indah as an Educational Cultural Tourism Destination for Generation Z Students
Authors:   Universitas Indonesia, Bramantya Yoga Akbar
Published: February 2025

The Merdeka Belajar Program is a new policy of the Ministry of Education and Culture of the Republic of Indonesia that provides students with the freedom to learn, pays attention to their natural talents, and gives teachers and students the freedom to innovate. This program is designed based on the needs and desires of students, and utilizes educational tourism objects as a means of learning. Taman Mini Indonesia Indah (TMII) is one of the educational tourism destinations that is suitable for learning about Indonesian culture and diversity through detailed miniatures. TMII displays miniature traditional houses from various provinces with the cultural characteristics of each province. TMII also provides various other facilities such as theaters, museums, and amusement parks. Through strategies involving technology and social media, TMII strives to be an interesting and modern place of learning for generation Z, with the aim of enriching their knowledge of Indonesia's cultural diversity and increasing public awareness of educational cultural heritage that is ideal to be part of the Merdeka Belajar program.
Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function
Authors: Gholamalamdari Omid , van Schaik Tom , Wang Yuchuan , Kumar Pradeep , Zhang Liguo , Zhang Yang , Gonzalez Gabriela A Hernandez , Vouzas Athanasios E , Zhao Peiyao A , Gilbert David M , Ma Jian , van Steensel Bas , Belmont Andrew S
Published: February 2025

Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here we integrated analysis of sequencing and image-based data to compare genome organization in four human cell types relative to three different nuclear locales: the nuclear lamina, nuclear speckles, and nucleoli. Whereas gene expression correlates mostly with nuclear speckle proximity, DNA replication timing correlates with proximity to multiple nuclear locales. Speckle attachment regions emerge as DNA replication initiation zones whose replication timing and gene composition vary with their attachment frequency. Most facultative LADs retain a partially repressed state as iLADs, despite their positioning in the nuclear interior. Knock out of two lamina proteins, Lamin A and LBR, causes a shift of H3K9me3-enriched LADs from lamina to nucleolus, and a reciprocal relocation of H3K27me3-enriched partially repressed iLADs from nucleolus to lamina. Thus, these partially repressed iLADs appear to compete with LADs for nuclear lamina attachment with consequences for replication timing. The nuclear organization in adherent cells is polarized with nuclear bodies and genomic regions segregating both radially and relative to the equatorial plane. Together, our results underscore the importance of considering genome organization relative to nuclear locales for a more complete understanding of the spatial and functional organization of the human genome.
Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration
Authors: Hahn Hyunggu , Daly Carole , Little John , Perry-Hauser Nicole A , Flores-Espinoza Emmanuel , Inoue Asuka , Plouffe Bianca , Thomsen Alex RB
Published: February 2025

Chemokine receptors are GPCRs that regulate the chemotactic migration of a wide variety of cells including immune and cancer cells. Most chemokine receptors contain features associated with the ability to stimulate G protein signaling during β-arrestin-mediated receptor internalization into endosomes. As endosomal signaling of certain non-GPCR receptors plays a major role in cell migration, we chose to investigate the potential role of endosomal chemokine receptor signaling on mechanisms governing this function. Applying a combination of pharmacological and cell biological approaches, we demonstrate that the model chemokine receptor CCR7 recruits G protein and β-arrestin simultaneously upon chemokine stimulation, which enables internalized receptors to activate G protein from endosomes. Furthermore, spatiotemporal-resolved APEX2 proteome profiling shows that endosomal CCR7 uniquely enriches specific Rho GTPase regulators as compared to plasma membrane CCR7, which is directly associated with enhanced activity of the Rho GTPase Rac1 and chemotaxis of immune T cells. As Rac1 drives the formation of membrane protrusions during chemotaxis, our findings suggest an important integrated function of endosomal chemokine receptor signaling in cell migration.
Epidemiological characteristics of patients with scabies at a Korean university hospital: a single-center retrospective study
Authors: Hwang Hye Eun , Jeong Jae Sim , Kim Yang Ree , Lee Ji young
Published: February 2025

Purpose: This study aimed to establish infection control strategies for preventing the spread of scabies within a single institution by analyzing the epidemiological characteristics of patients diagnosed with scabies. Methods: This was a retrospective descriptive study. The electronic medical records of 430 patients diagnosed with scabies at the dermatology outpatient department of Uijeongbu St. Mary’s Hospital from January 2020 to December 2022 were used to collect data on their characteristics. The subjects were divided into three groups: patients, family of confirmed patients, and healthcare workers. General and epidemiological characteristics were analyzed. Results: The average age was 60.89 ± 22.39 years. The number of days from symptom onset to diagnosis was unknown in many cases (65.3%), although the average was 63.42 ± 64.18 days. Repeated visits after treatment were observed in 193 patients (67.5%), 38 family members of confirmed patients (55.1%), and 35 healthcare workers (46.7%), showing a statistically significant difference (p = .002). The most common place of residence before the visit was home (56.2%), and the most common suspected origin of contagion was the home (38.3%), and the most common category of the suspected contagious person was family (49.6%). Conclusion: Cases of scabies were disproportionately common in women and older adults. The interval from symptom onset to diagnosis was long, and about half of the cases involved itching but no skin lesions. More than one-thirds of cases did not revisit for a follow-up after 2 weeks. In the overall results, unlike previous studies, factors related to home and family were frequently observed as epidemiological characteristics.
A conceptual replication of the Psychological Typhoon Eye effect in the aftermath of the Petrinja earthquake in Croatia
Authors: Mertens Gaëtan , Dürrigl Marta
Published: February 2025

Background

The Psychological Typhoon Eye (PTE) effect refers to the observation that those living in the epicenters of natural disasters or public emergencies exhibit lower levels of psychological distress than those living further away. The effect has been described in the aftermath of multiple public emergencies, including the 2008 Wenchuan earthquake. However, despite its potential importance for emergency relieve, this phenomenon has received little research attention and requires further replication. The goals of this study were to replicate the PTE effect using both the original items used in prior research and using the validated Depression, Anxiety, and Stress Scales (DASS).

Methods

A cross-sectional survey was conducted following an earthquake with a magnitude of 6.4 on the Richter scale that occurred in December 2020 in Petrinja, Croatia. The sample consisted of 316 participants living in Croatia at the time of the earthquake. Questionnaires were administered through an online survey, including the DASS, the items used in previous research, and questionnaires measuring general and earthquake-specific coping. Exposure to the earthquake was operationalized as the degree of devastation participants had experienced (i.e., the degree of structural damage to their home as assessed by local authorities). In line with previous work, we tested for an inverse relationship between the experienced level of devastation and the different measures of psychological distress (i.e., the items used in previous work and the DASS).

Results

We found no evidence for the PTE effect in our study. Instead, we observed a ripple effect, whereby those most affected by the earthquake showed the most psychological distress. We argue that the ripple effect, rather than the PTE effect, should be seen as the default psychological response pattern to natural disasters and emergencies.
Current trends in the epidemiology of multidrug-resistant and beta-lactamase-producing Pseudomonas aeruginosa in Asia and Africa: a systematic review and meta-analysis
Authors: Salleh Mohd Zulkifli , Nik Zuraina Nik Mohd Noor , Deris Zakuan Zainy , Mohamed Zeehaida
Published: February 2025

Pseudomonas aeruginosa continues to be a significant contributor to high morbidity and mortality rates worldwide, particularly due to its role in severe infections such as hospital-acquired conditions, including ventilator-associated pneumonia and various sepsis syndromes. The global increase in antimicrobial-resistant (AMR) P. aeruginosa strains has made these infections more difficult to treat, by limiting the effective drug options available. This systematic review and meta-analysis aim to provide an updated summary of the prevalence of AMR P. aeruginosa over the past 5 years. A systematic search was performed across three major electronic databases—PubMed, ScienceDirect, and Web of Science—yielding 40 eligible studies published between 2018 and 2023. Using a random-effects model, our meta-analysis estimated that the overall prevalence of P. aeruginosa in Asia and Africa over the past 5 years was 22.9% (95% CI [14.4–31.4]). The prevalence rates for multidrug-resistant (MDR) and extensively drug-resistant (XDR) P. aeruginosa strains were found to be 46.0% (95% CI [37.1–55.0]) and 19.6% (95% CI [4.3–34.9]), respectively. Furthermore, the prevalence rates of extended-spectrum β-lactamase- and metallo-β-lactamase-producing P. aeruginosa were 33.4% (95% CI [23.6–43.2]) and 16.0% (95% CI [9.8–22.3]), respectively. Notably, resistance rates to β-lactams used for treating pseudomonal infections were alarmingly high, with rates between 84.4% and 100.0% for cephalosporins, and over 40% of P. aeruginosa isolates showed resistance to penicillins. Our analysis identified the lowest resistance rates for last-resort antimicrobials, with 0.3% (95% CI [0.0–1.3]) resistance to polymyxin B and 5.8% (95% CI [1.5–10.2]) to colistin/polymyxin E. The low resistance rates to polymyxins suggest that these antibiotics remain effective against MDR P. aeruginosa. However, the findings also highlight the critical public health threat posed by antimicrobial-resistant P. aeruginosa, particularly concerning β-lactam antibiotics. This underscores the need for effective and carefully planned intervention strategies, including the development of new antibiotics to address the growing challenge of resistance. Developing robust antibiotic treatment protocols is essential for better management and control of pseudomonal infections globally. Therefore, continued research and international collaboration is vital to tackle this escalating public health challenge. This study protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO), under registration number CRD42023412839.
Predictors of outcome among children with biliary atresia: a single centre trial
Authors: Ye Chaoxiang , Gao Wei
Published: February 2025

Objective

This study aimed to investigate the predictive role of preoperative gamma-glutamyl transpeptidase (GGT) levels on the prognosis of neonatal biliary atresia (NBA) in patients who underwent the Kasai procedure.

Methods

A retrospective analysis was conducted of patients with NBA who underwent the Kasai procedure at our hospital from 2017 to 2021. Patients were categorized into high (GGT > 300 IU/L) and GGT inadequate (GGT ≤ 300 IU/L) groups based on preoperative GGT levels. The influence of GGT levels on NBA prognosis was evaluated by comparing clinical data, age at operation, jaundice normalization, and survival outcomes between the groups.

Results

A total of 74 patients with NBA were included, with 59 in the high GGT group and 15 in the GGT inadequate group. Ages at the time of the Kasai procedure ranged from 31 to 106 days, with a median of 61 days; the average weight was 4.8 ± 1.1 kg. Two years post-procedure, 56 patients (75.7%) survived with their native liver (P < 0.0001). At 3 months post-procedure, alanine aminotransferase (ALT) levels were significantly higher in the GGT inadequate group compared to the high GGT group (3.5 times vs. 2.3 times the upper limit of normal, P = 0.0259). Significant differences in GGT levels persisted 1-month post-procedure (P = 0.0473). Jaundice clearance was significantly higher in the high GTT group (P = 0.0171) after 6 months. Multivariate logistic regression indicated a substantially higher mortality rate in the GGT inadequate group (P = 0.0452), with no significant age difference at operation (P = 0.8449). Preoperative GGT is a valuable predictor for NBA prognosis (area under the curve (AUC) 0.754, 95% confidence interval CI [0.640–0.847], P = 0.001, specificity 91.1%, and sensitivity 61.1%).

Conclusions

High preoperative GGT levels predict better prognosis in patients with NBA undergoing Kasai operation.
Qualitative Study of Phytocompounds Antiradical Potential from Selective Extracts of three Plants Used in Neurodegenerative Diseases Traditherapy in Côte d'Ivoire
Authors: Venance Konan Kouakou , Akhanovna Mamyrbekova-Békro Janat , Jean-Luc Pirat , Yves-Alain Békro
Published: February 2025

The Ivorian flora is rich in plants of interest, some of which are used to treat neurodegenerative diseases. Among them, Nauclea latifolia (NL), Bombax costatum (BC) and Vernonia cinerea(VC) were studied for their potential. This qualitative research focuses on the phytochemical  screening and the evaluation of the antioxidant power of selective extracts hexane, chloroform,  ethyl acetate and n-butanol of these plants. These extracts were obtained by a series of successive extractions with solvents varying according to polarity, revealing the presence of to the synergistic action of these phytochemical families, explaining their neuroprotective effects.
In-vitro Antibacterial and Antifungal Activities of the Stem Bark Extract and Fractions of Warbugia. ugadensis, Prunus africana and Albizia gummifera from Mt Kenya and Elgon Regions in Kenya
Authors: Holland Shoso Luvembe , Wanyonyi Alphonse Wafula , Mwangi Henry
Published: February 2025

Fungal and bacterial infections pose a major global public health challenge due to rising antimicrobial resistance. Over 50% of hospital infections now involve pathogens resistant to multiple drugs, contributing to higher death rates, longer patient illness, and increased/prolonged hospital stays. Exploration of medicinal plants' phytochemical properties provides one avenue for developing new treatment options outside the traditional drug development process to address the intensifying antimicrobial resistance crisis. The plant materials were subjected to cold maceration followed by liquid-liquid partitioning using hexane, dichloromethane (DCM), and ethyl acetate in order of increasing polarity. The derived methanol extracts were screened for phytochemicals using standard procedures. The disk diffusion method evaluated the antimicrobial activity of 50mg/mL of W. ugadensis, P. africana, and A. gummifera against S. aureus, E. coli, and C. albicans. The study qualitatively and quantitatively assessed antibacterial and antifungal activities by observing inhibition zones and determining minimum inhibitory concentration (MIC) values.  Several bioactive compounds were detected in the methanolic extract of these plants such as saponins, alkaloids, terpenoids, tannins, flavonoids, phenols, and glycosides. Preliminary disk diffusion screening revealed that W. ugadensis DCM extract exhibited the strongest antimicrobial activity against C. albicans, E. coli, and S. aureus, with mean inhibition zones of 21.0, 10.3, and 15.7mm respectively. MIC analyses with 96-well microliter plate assays confirmed S. aureus as the most susceptible and E. coli as the least vulnerable to the extracts. Tukey’s Multiple Comparison Test (P < 0.05) demonstrated significant differences in antimicrobial activity among A. gummifera, W. ugandensis, and P. africana. The inhibition of the various plant extracts against the tested microorganisms indicates that further study could reveal their potential use in treating infections caused by these microorganisms.  Additional research is required to fully elucidate their therapeutic potential and explore practical applications for combating microbial infections.
United States v Skrmetti—Testing the Transition to Politicized Regulation of Medicine
Authors: Huberfeld Nicole , Ulrich Michael R.
Published: January 2025

This Viewpoint discusses Tennessee’s ban on gender-affirming care for transgender youth and how the US Supreme Court’s decision on the constitutionality of this law could have potential implications for state regulation of medical practice.
Gamification With a Support Partner and Postoperative Mobility in Older Adults Undergoing Radical Cystectomy
Authors: Lee Daniel , Rareshide Charles , Mondal Angira , Patel Mitesh S. , Greysen S. Ryan
Published: January 2025

This randomized clinical trial examines the effects of a gamified program for older adults to meet daily and weekly step goals following radical cystectomy procedures.
Development of activities by nonresidents through “ko”
Authors: Morita Ryoya , Goto Haruhiko , Yamazaki Yoshito
Published: January 2025

An effective method to develop the activities of nonresidents in the area of the Tenkawa shrine is to offer extraordinary experiences in which people can participate casually through “ko” to enhance religious culture based on the shrine's history. This can also increase the sustainability of the area where the shrine is located, as the charm of the shrine has attracted several households, which have moved into the village in recent years.
Chemo‐Mechanics Interplay Dictates Interface Instability and Asymmetry in Plating and Stripping of Sodium Metal Electrodes
Authors: Singla Aditya , Naik Kaustubh G. , Vishnugopi Bairav S. , Mukherjee Partha P.
Published: January 2025

The development of practical sodium (Na) metal batteries is hindered by key challenges including dendrite growth, dead metal formation, and unstable solid electrolyte interphase (SEI) growth. A fundamental understanding of the chemo‐mechanical interactions at the Na/SEI interface is critical for designing stable Na metal electrodes. In this work, the coupled electrochemical‐mechanical processes governing the morphological evolution and stability of Na metal during plating and stripping are investigated. The heterogeneous nature of transport and morphological interactions at the Na/SEI interface is revealed to result in nonuniform mechanical overpotentials and reaction fronts, eventually leading to Na filaments or pits. The spatio‐temporal evolution of stress heterogeneities during Na plating and stripping is shown to be asymmetric, manifesting in varying morphological nonuniformities and instability modes. The crucial role of external pressure in modulating the electrochemical‐transport interactions, the mechanical response of Na, and the localized reaction currents and stresses at the Na/SEI interface is demonstrated. At different external pressure conditions, the correlation between transport heterogeneities in the SEI and the onset and propagation of interface instability has been delineated. This work highlights the need for synergistic tailoring of external pressure and SEI heterogeneity toward achieving stable electrodeposition and dissolution in Na metal electrodes.
Integrated Underwater X‐Ray Detector Arrays Fabricated by Perovskite Single‐Crystal Arrays
Authors: Zhang Jianglei , Li Weijun , Yang Yifan , Tang Zigao , Wei Haotong , Zhang Junhu , Yang Bai
Published: January 2025

Given the promising application prospects of underwater X‐ray detection technology, traditional perovskite materials, despite their outstanding performance in X‐ray detection, are significantly constrained by their inherent susceptibility to hydrolysis, hindering their effective utilization in underwater environments. To date, most efforts are devoted to evaluating these materials' performance under atmospheric conditions, with a limited exploration into their adaptability in underwater settings. In this study, the successful fabrication of thick perovskite single‐crystal arrays with a thickness of 400 µm and their integration into a stable underwater X‐ray detector array is demonstrated. The single‐crystal arrays exhibit remarkable uniformity in both alignment and dimensions, thereby contributing to improved detection homogeneity and enhanced underwater imaging capabilities. The detector arrays exhibit exceptional X‐ray detection performance, characterized by a high sensitivity of 155,020 µC·Gy−1·cm−2 at 5 V bias and a low detection limit of 52 nGy·s−1, which represents a significant advancement in the frontier of perovskite‐based materials for underwater X‐ray detection. After continuous submersion in water for over 60 days, the detector array maintains its initial X‐ray detection performance, proving its stable adaptability to the underwater environment.
Trace NaBF4 Modulated Ultralow‐Concentration Ether Electrolyte for Durable High‐Voltage Sodium‐Ion Batteries
Authors: Li Shuaiqi , Song Xinrui , Jing Pengwei , Xiao Xiyue , Chen Yuecong , Sun Qing , Huang Maxiong , Zhang Yiping , Li Guosheng , Liu Pengyu , Xu Shan , Dou Qingyun , Zhu Jian , Yan Xingbin
Published: January 2025

Ultralow‐concentration ether electrolytes hold great promise for cost‐effective sodium‐ion batteries (SIBs), while their inferior cycle stability under high voltages remains an awkward challenge. Herein, ultralow‐concentration diglyme (G2)‐based electrolytes with single sodium salt are found to manifest high‐rate capability when employed for high‐voltage Na3(VOPO4)2F (NVOPF) cathode, but their specific capacity rapidly depletes to exhaustion during long‐term cycling. To address this issue, trace NaBF4 (0.03 m) as electrolyte additive is introduced, which minimally affects ion conductivity of the pristine electrolyte, yet weakens the coordination between Na+ ions and G2 molecules. This allows more PF6− to enter the solvation sheath of Na+ ions, forming a more stable cathode electrolyte interphase and enhancing the cycle performance without sacrificing high‐rate performance (up to 20 C). As a result, the trace NaBF4 modulated G2‐based electrolyte enables the NVOPF cathode to cycle steadily, with a capacity retention of 94.2% over 1000 cycles at a low rate of 1 C. This work provides valuable insights into the modulation of ultralow‐concentration ether electrolytes for use in durable high‐voltage SIBs.
An Agile 3 cm‐Scale Quadruped Piezoelectric Robot with a Rigid Ring‐Shaped Structure
Authors: Li Jing , Liu Baoyi , Chen Weishan , Zhang Shijng , Deng Jie , Liu Yingxiang
Published: January 2025

Miniature piezoelectric robots can perform various tasks in narrow spaces, due to their small sizes and agile motions. However, there is key challenge of reconciling large load capacity with agile motions, which limits the integration of functional units. In this work, a miniature agile quadruped piezoelectric robot (AQPR) inspired by hard‐shell animals is proposed. The prominent feature of AQPR is the rigid ring structure, which can be utilized to achieve large load capacity with its high stiffness; the degeneracy of different vibration modes is used to generate multi‐dimensional trajectories at the foot, which can achieve linear and rotational motions. A prototype with size of 30 × 30 × 14.3 mm3 and weight of 6.9 g is produced. The experimental results show that the maximum linear and rotational speed is 255 mm s−1 and 1265°s−1, respectively. The load capacities reach 200 g (≈30 times self‐weight). By using an impulse signal, the resolutions of linear and rotational motions reach 0.25 µm and 32.7 µrad, respectively. Benefiting from small size, large load capacity, high resolution, agile, and fast speed, AQPR shows great potential for applying micro‐operations in narrow spaces, such as large‐scale wafer transport and detection.
3D Bioprinted Head and Neck Squamous Cell Carcinoma (HNSCC) Model Using Tunicate Derived Nanocellulose (NC) Bioink
Authors: Azhakesan Alexya , Kern Johann , Mishra Ankit , Selhuber‐Unkel Christine , Affolter Annette , Gatenholm Paul , Rotter Nicole , Bieback Karen
Published: January 2025

Head and neck squamous cell carcinoma (HNSCC) are invasive solid tumors accounting for high mortality. To improve the clinical outcome, a better understanding of the tumor and its microenvironment (TME) is crucial. Three ‐dimensional (3D) bioprinting is emerging as a powerful tool for recreating the TME in vitro. To establish long‐term HNSCC bioprinted constructs for personalized drug‐testing, this proof‐of‐principle study aims to compare two different innovative tunicate‐derived nanocellulose (NC) hydrogels against the widely used semi‐synthetic gelatin methacryloyl (GelMA). Cell lines of different tumor origin sites are printed in TEMPO and Carboxy‐NC, and GelMA in alginate (GelMAA). Both NC hydrogels show higher bioprintability than GelMAA. Carboxy‐NC supported long‐term HNSCC survival, proliferation, and maintenance of epithelial phenotype in 3D bioprinted constructs similar to GelMAA. The hydrogel microstructure revealed differences in pore size. Importantly, the established HNSCC bioprinted model allowed the testing of radiochemotherapy (RCT) both in cell lines and patient‐derived cultures. Compared to a spheroid model, the cytotoxic effects are less, better reflecting the response in patients. The proof‐of‐principle findings indicate that Carboxy‐NC is a viable alternative to gelatin‐based bioink with improved bioprintability allowing personalized drug‐testing. By adding other cell‐types of the TME, this model can be advanced to a heterotypic one.
Ring‐Opening Polymerization of Surface Ligands Enables Versatile Optical Patterning and Form Factor Flexibility in Quantum Dot Assemblies
Authors: Lee Yunseo , Shin Jiyun , Shin Seungki , Kim Eun A , Lee Joon Yup , Gwak Namyoung , Kim Seongchan , Seo Jaeyoung , Kong Hyein , Yeo Dongjoon , Na Jina , Kim Sungwon , Lee Juho , Cho Seong‐Yong , Lee Jaejun , Kim Tae Ann , Oh Nuri
Published: January 2025

The evolution of display technologies is rapidly transitioning from traditional screens to advanced augmented reality (AR)/virtual reality (VR) and wearable devices, where quantum dots (QDs) serve as crucial pure‐color emitters. While solution processing efficiently forms QD solids, challenges emerge in subsequent stages, such as layer deposition, etching, and solvent immersion. These issues become especially pronounced when developing diverse form factors, necessitating innovative patterning methods that are both reversible and sustainable. Herein, a novel approach utilizing lipoic acid (LA) as a ligand is presented, featuring a carboxylic acid group for QD surface attachment and a reversible disulfide ring structure. Upon i‐line UV exposure, the LA ligand initiates ring‐opening polymerization (ROP), crosslinking the QDs and enhances their solvent resistance. This method enables precise full‐color QD patterns with feature sizes as small as 3 µm and pixel densities exceeding 3788 ppi. Additionally, it supports the fabrication of stretchable QD composites using LA‐derived monomers. The reversible ROP process allows for flexibility, self‐healing, and QD recovery, promoting sustainability and expanding QD applications for ultra‐fine patterning and on‐silicon displays.
Multiple Electron Transfers Enable High‐Capacity Cathode Through Stable Anionic Redox
Authors: Wu Lichen , Dai Zhongqin , Fu Hongwei , Shen Mengkang , Cha Limei , Lin Yue , Sun Fanfei , Rao Apparao M. , Zhou Jiang , Wen Shuangchun , Lu Bingan
Published: January 2025

Single‐electron transfer, low alkali metal contents, and large‐molecular masses limit the capacity of cathodes. This study uses a cost‐effective and light‐molecular‐mass orthosilicate material, K2FeSiO4, with a high initial potassium content, as a cathode for potassium‐ion batteries to enable the transfer of more than one electron. Despite the limited valence change of Fe ions during cycling, K2FeSiO4 can undergo multiple electron transfers via successive oxygen anionic redox reactions to generate a high reversible capacity. Although the formation of O‒O dimers in K2FeSiO4 occur upon removing large amounts of potassium, the strong binding effect of Si on O mitigates irreversible oxygen release and voltage degradation during cycling. K2FeSiO4 achieves 236 mAh g−1 at 50 mA g−1, with an energy density of 520 Wh kg−1, which can be comparable with commercial LiFePO4 materials. Moreover, it also exhibits 1400 stable cycles under high‐current conditions. These findings enhance the potential commercialization prospects for potassium‐ion batteries.
Polarity‐selective Transfer of Lipophilic Cargoes From Lipid Droplets (Oleosomes) to Lipid Bilayers
Authors: Vardar Umay Sevgi , Bitter Johannes H. , Nikiforidis Constantinos V.
Published: January 2025

Lipid Droplets (LDs) or as also called oleosomes are lipid storage organelles in eukaryotic cells. Besides storing lipids, LDs can fuse their core into other intracellular organelles, but the mechanism remains unknown. In this work, this is aimed to understand the effect of cargo's polarity on the transportation of the cargo from LDs to lipid bilayers using liposomes. LDs are loaded with curcumin and Nile red, two lipophilic molecules with similar log P values. The loaded LDs are blended with liposomes, while curcumin and Nile red are tracked using confocal microscopy and spectroscopy. LDs remained intact, while curcumin was transferred in 5 min from LDs to liposomes. Nile red remained in LDs. The difference between curcumin and Nile red is attributed to the amphiphilicity of curcumin, which allowed its adsorption in the LD monolayer and the subsequent transportation to the liposome bilayer upon contact. The unique selectivity of LDs is shown as carriers since lipophilic cargo is transferred to the lipid bilayer only when participating in the LD membrane. The understanding of the transportation mechanism of molecules from LDs to bilayers helps the exploitation of LDs as natural lipid carriers.