bluuebunny/crossref_metadata_2025 huggingface dataset:
Underfunding Basic Psychological Science Because of the Primacy of the Here and Now: A Scientific Conundrum
Authors: Almeida Jorge
Published: September 2022

The psychological sciences are suffering from the primacy of the “here and now” and from a radical utilitarian view of science—this is certainly true in less affluent countries around the world. Portugal is a particular case study, as both psychology departments and funding agencies are largely biased toward applied psychology—but this is a more global trend. The field needs to find a balance between applied and basic psychology to better respond to the challenges of tomorrow.
Short-acting beta-2 agonist prescription patterns and clinical outcomes in Chinese patients with asthma: an observational study in mainland China for the SABINA programme
Authors: Bao Wuping , Zhang Yingying , Hang Jingqing , Guo Yubiao , Tang Wei , Yun Chunmei , Deng Jingmin , Jin Meiling , Lai Kefang , Yu Huapeng , Beekman Maarten , Zhou Xin , Zhang Min
Published: September 2022

Objectives:

The SABINA CHINA study aimed to determine prescription data for asthma medication with a focus on SABA and ICS in a representative population of patients with asthma in China.

Methods:

SABINA China was a multicentre, observational, cross-sectional study with data collected retrospectively from a convenience sample of 25 tertiary centres across China. Patients (age ⩾ 12 years) with ⩾3 consultations/year were enrolled. Data were collected on clinical characteristics, asthma severity, and symptom control (as per GINA 2017), treatment and history of severe exacerbations over the past year. SABA over-prescription was defined as ⩾3 SABA canisters/year. Descriptive statistics are presented.

Results:

Between March and August 2020, 498 patients were included in the outcome analysis. Mean (SD) age was 48.7 (15.0) years, 57.9% were female and 91% had moderate-to-severe asthma ( n = 453). Overall, 12.5% ( n = 62) and 26.4% ( n = 131) of patients had uncontrolled and partly controlled asthma, respectively. SABA add-on was prescribed to 20.3% ( n = 101) of patients; one patient with moderate-to-severe asthma was prescribed SABA-alone. SABA over-prescription in the overall population was 4.0% ( n = 20; all with moderate-to-severe asthma) and 19.8% (20/101) among those prescribed SABA add-on. In the mild asthma group, 50% ( n = 22) were prescribed ICS/LABA and 43.2% ( n = 19) were prescribed LTRA. Among those with moderate-to-severe asthma, 97.4% ( n = 441) were prescribed ICS/LABA and 55.0% ( n = 249) were prescribed LTRA. Approximately 30% of patients ( n = 149) experienced ⩾1% and 6.6% ( n = 33) ⩾3 severe exacerbations in the preceding year; mean annual number of severe exacerbation/patient was 0.6 (1.2). Among those prescribed SABA add-on, ICS/LABA and LTRA (non-mutually exclusive groups due to overlapping prescriptions), 54.5%, 29.9%, and 35.3% had ⩾1 severe exacerbations, respectively.

Conclusion:

Among patients with predominantly moderate-to-severe asthma managed in tertiary care and were prescribed SABA, 1 in 5 received ⩾3 canisters/year. Fewer patients who received ICS/LABA prescriptions experienced annual exacerbations than those prescribed SABA add-on.
‘That would have been the perfect thing after diagnosis’: development of a digital lifestyle management application in multiple sclerosis
Authors: Krause Nicole , Riemann-Lorenz Karin , Rahn Anne Christin , Pöttgen Jana , Köpke Sascha , Meyer Björn , Thale Frithjof , Temmes Herbert , van de Loo Markus , Gold Stefan M. , Heesen Christoph
Published: September 2022

Background:

A multiple sclerosis (MS) diagnosis urges decision-making on immunotherapies, while persons with MS (PwMS) need to develop a coping concept in parallel. At this stage, PwMS ask how they themselves may contribute to controlling the disease. Evidence suggests that maintaining a healthy lifestyle (e.g. physical activity and stress management) is a key factor for healthy aging and preserving activity, while data on MS are complex.

Objectives:

Following the Medical Research Council framework, this study aimed to develop and investigate the feasibility of a new digital health application that conveys evidence-based patient information about lifestyle factors in MS and engages PwMS in relevant behaviour change techniques.

Methods:

Based on a digital health application promoting lifestyle management in breast cancer survivors, an MS-specific adaptation (‘levidex’) was developed. Feasibility was tested with 15 PwMS and eight MS experts. Subsequently, a six-week pilot study with eight PwMS was conducted. All participants provided feedback on practicability and acceptability via a questionnaire and took part in a semi-structured telephone interview. Levidex was revised after each test phase.

Results:

The final levidex tool includes 16 modules, 177 references and several other functions. Feasibility results showed that PwMS and MS experts perceived levidex as understandable (14 out of 15; 6 out of 8), trustworthy (15 out of 15; 8 out of 8), and relevant (10 out of 15; 8 out of 8). Interviews revealed potential for improvement regarding the length and complexity of some content. Piloting of the revised version confirmed good feasibility and high acceptance. Most participants felt inspired to initiate (7 out of 8) or had already implemented (5 out of 8) lifestyle changes after working with levidex.

Conclusion:

Results suggest that levidex is feasible and well-accepted by PwMS and MS experts. It might be a useful tool to support PwMS in adapting to their diagnosis and initiating health-promoting lifestyle changes.
Targeted therapy for pediatric diffuse intrinsic pontine glioma: a single-center experience
Authors: Del Baldo Giada , Carai Andrea , Abbas Rachid , Cacchione Antonella , Vinci Mara , Di Ruscio Valentina , Colafati Giovanna Stefania , Rossi Sabrina , Diomedi Camassei Francesca , Maestro Nicola , Temelso Sara , Pericoli Giulia , De Billy Emmanuel , Giovannoni Isabella , Carboni Alessia , Rinelli Martina , Agolini Emanuele , Mackay Alan , Jones Chris , Chiesa Silvia , Balducci Mario , Locatelli Franco , Mastronuzzi Angela
Published: September 2022

Background:

Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the mainstay treatment. Several other therapeutic strategies have been attempted in the last years without a significant effect on OS. Although radiological imaging is the gold standard for DIPG diagnosis, the urgent need to improve the survival has led to the reconsideration of biopsy with the aim to better understand the molecular profile of DIPG and support personalized treatment.

Methods:

In this study, we present a single-center experience in treating DIPG patients at disease progression combining targeted therapies with standard of care. Biopsy was proposed to all patients at diagnosis or disease progression. First-line treatment included RT and nimotuzumab/vinorelbine or temozolomide. Immunohistochemistry-targeted research included study of mTOR/p-mTOR pathway and BRAFv600E. Molecular analyses included polymerase chain reaction, followed by Sanger sequences and/or next-generation sequencing.

Results:

Based on the molecular profile, targeted therapy was administered in 9 out of 25 patients, while the remaining 16 patients were treated with standard of care. Personalized treatment included inhibition of the PI3K/AKT/mTOR pathway (5/9), PI3K/AKT/mTOR pathway and BRAFv600E (1/9), ACVR1 (2/9) and PDGFRA (1/9); no severe side effects were reported during treatment. Response to treatment was evaluated according to Response Assessment in Pediatric Neuro-Oncology criteria, and the overall response rate within the cohort was 66%. Patients treated with targeted therapies were compared with the control cohort of 16 patients. Clinical and pathological characteristics of the two cohorts were homogeneous. Median OS in the personalized treatment and control cohort was 20.26 and 14.18 months, respectively ( p = 0.032). In our experience, the treatment associated with the best OS was everolimus.

Conclusion:

Despite the small simple size of our study, our data suggest a prognostic advantage and a safe profile of targeted therapies in DIPG patients, and we strongly advocate to reconsider the role of biopsy for these patients.
Survival benefit of HER2-targeted or androgen deprivation therapy in salivary duct carcinoma
Authors: Kawakita Daisuke , Nagao Toshitaka , Takahashi Hideaki , Kano Satoshi , Honma Yoshitaka , Hirai Hideaki , Saigusa Natsuki , Akazawa Kohei , Tani Kaori , Ojiri Hiroya , Tsukahara Kiyoaki , Ozawa Hiroyuki , Okami Kenji , Kondo Takahito , Togashi Takafumi , Fushimi Chihiro , Shimura Tomotaka , Shimizu Akira , Okamoto Isaku , Okada Takuro , Imanishi Yorihisa , Watanabe Yoshihiro , Otsuka Kuninori , Sakai Akihiro , Ebisumoto Koji , Sato Yuichiro , Yamazaki Keisuke , Ueki Yushi , Hanazawa Toyoyuki , Saito Yuki , Ando Mizuo , Matsuki Takashi , Nakaguro Masato , Sato Yukiko , Urano Makoto , Utsumi Yoshitaka , Kohsaka Shinji , Saotome Takashi , Tada Yuichiro
Published: September 2022

Background:

The efficacy and safety of human epidermal growth factor receptor 2 (HER2)-targeted therapy and androgen deprivation therapy (ADT) for locally advanced or recurrent or metastatic (LA/RM) salivary duct carcinoma (SDC) have been reported in prospective studies. However, the survival benefit of these therapies to conventional therapy remains controversial, and whether HER2-targeted therapy or ADT should be chosen in HER2- and androgen receptor (AR)-positive SDC patients remains unknown.

Methods:

Overall, 323 LA/RM SDC patients treated at seven institutions between August 1992 and June 2020 were retrospectively enrolled. The primary aim was to analyze the effect of HER2-targeted therapy and ADT on overall survival from the diagnosis of LA/RM disease to death from any cause (OS1). The secondary indicators included the overall response rate (ORR), clinical benefit rate (CBR), overall survival from therapy initiation for LA/RM disease (OS2), progression-free survival (PFS), time to second progression (PFS2), duration of response (DoR), and duration of clinical benefit (DoCB) of HER2-targeted therapy or ADT as first-line therapy for HER2-positive/AR-positive SDC.

Results:

Patients treated with HER2-targeted therapy or ADT had longer OS1 than those treated without these therapies (Median OS1: historical control, 21.6 months; HER2-targeted therapy, 50.6 months; ADT, 32.8 months; HER2-targeted therapy followed by ADT, 42.4 months; and ADT followed by HER2-targeted therapy, 45.2 months, p < 0.001). Among HER2-positive/AR-positive SDC patients, although HER2-targeted therapy had better ORR, CBR, and PFS than those of ADT as first-line therapy, we found no significant differences between HER2-targeted therapy and ADT regarding OS2, PFS2, DoR, and DoCB.

Conclusion:

Patients treated with HER2-targeted therapy and ADT showed longer survival in LA/RM SDC. HER2-targeted therapy can be recommended prior to ADT for HER2-positive/AR-positive SDC. It is warranted to establish a biomarker that could predict the efficacy of clinical benefit or better response in ADT.
A Content Analysis of the American String Teacher (2000–2019)
Authors: Zabanal John Rine A. , Chang Annalisa C. , Lofdahl Heather A.
Published: September 2022

The purpose of this study was to examine featured articles ( n = 376) and authors ( n = 415) published in the American String Teacher from 2000 through 2019. Articles were coded into 1 of 24 categories using a researcher-designed codebook based on article content. Authors were coded into one of four professional position categories based on information provided in their biographies and by gender based on included pronouns. Article content codes with the highest overall percentages included profession (14.86%), instrument pedagogy (13.83%), and repertoire/instructional materials (11.44%). Within the instrument pedagogy category, articles that primarily focused on violin (23.08%) were the most common, and those focused on the guitar (3.85%) and harp (1.92%) were the least common. Article content codes with the lowest overall percentages included exceptional learners (0.53%), assessment (0.53%), and administration/business (0.80%). Authors were primarily men ( n = 53.49%) and held positions in higher education ( n = 54.22%). A significant negative trend was found for authors categorized as applied arts, where applied arts authors decreased from 23.81% in 2000 to 21.74% in 2019.
Breastfeeding With Infectious Diseases
Authors: Yeo Samantha , Yang Liying , Ong Kirsten , Yong Tze Tein
Published: September 2022

Aims: Human breast milk remains an important source of protection against infection, inflammation, allergy and long-term metabolic disorders for the breastfed offspring. During cases of ongoing infection, the dilemma faced by both medical health professionals and mothers is the need to balance the risk of continuing versus temporarily or permanently ceasing to breastfeed. The aim of our article is to review existing literature regarding breastfeeding during acute infectious and non-infectious illnesses and to provide feasible evidence-based suggestions which can be implemented by medical practitioners during counselling of breastfeeding mothers.

Method: A literature search was conducted on PubMed (US National Library of Medicine) using various combinations of keywords related to breastfeeding and the various infections. The citations from all selected articles were reviewed for additional studies.

Results: Most ongoing infections are not contraindications for breastfeeding, with the exceptions of Human Immunodeficiency viruses (HIV), Human T-cell lymphotropic virus (HTLV) types 1 and 2. Even with HIV, there is increasing evidence to reassure that with adequate antiretroviral therapy, breastfeeding is likely to be safe. Of particular concern during the COVID-19 pandemic too, current evidence indicates that mothers with COVID-19 infection can safely breastfeed, and therefore initiation and continuation of breastfeeding should continue to protect the health of the babies and mothers.

Conclusion: During this pandemic especially, there is a strong and urgent need to support mothers with acute infections who wish to breastfeed. With better awareness, physicians can play an important role in securing positive experiences for breastfeeding mothers and optimizing infant outcomes.
Remission and relapses of myasthenia gravis on long-term tacrolimus: a retrospective cross-sectional study of a Chinese cohort
Authors: Bi Zhuajin , Cao Yayun , Liu Chenchen , Gui Mengcui , Lin Jing , Zhang Qing , Li Yue , Ji Suqiong , Bu Bitao
Published: September 2022

Objective:

To identify the factors that predict the remission and relapses in myasthenia gravis (MG) patients improved by prednisone and tacrolimus treatment.

Methods:

A retrospective, observational cohort analysis of MG patients who achieved remission after receiving prednisone and tacrolimus were performed at Tongji Hospital. The main outcome measures were the time to remission, prednisone discontinuation, tacrolimus reduction–associated relapse, and treatment outcome.

Results:

After adding tacrolimus, 256 patients were able to achieve remission with a mean time to remission of 2.1 ± 1.4 months. After a median follow-up of 2.9 years, 167 patients (65.2%) discontinued prednisone, and 20 patients (7.8%) achieved complete stable remission. Moreover, 53 of the 109 patients who were tapering tacrolimus experienced relapses. In multivariable analysis, female sex, low tacrolimus concentrations, and quantitative myasthenia gravis (QMG) scores have a positive correlation with the time to remission; concomitant additional autoimmune disease (AID) and high anti-acetylcholine receptor antibody (AChR-ab) levels were significantly associated with low probabilities of prednisone discontinuation [odds ratio (OR) = 0.312–0.912, respectively]; rapid tacrolimus decrement speed (⩾0.76 mg/year) was an independent predictor for the development of relapse during tapering tacrolimus (OR = 5.662).

Conclusion:

Sex, tacrolimus concentrations, and QMG scores can be used as potential predictors of the time to remission in MG patients treated with tacrolimus and prednisone. Prednisone should be tapered slowly, especially in patients with additional AID or high serum titers of AChR-ab. To avoid symptoms recurrence, the dose of tacrolimus should reduce slowly, not exceeding 0.76 mg/year.
Proprioceptive art: How should it be defined, and why has it become so popular?
Authors: Spence Charles
Published: September 2022

In recent years, there has been something of an explosion of interest in those artworks and installations that directly foreground the bodily senses. Often referred to as proprioceptive (or prop.) art, the question to be addressed in this narrative historical review is how it should be defined, and why has it become so popular? A contrast is drawn with examples of sculpture and/or tactile art. The entertainment/experiential element of such works cannot be denied, especially in an era where funding in the arts sector is so often linked to footfall. At the same time, however, a number of the works appear to be about little more than entertainment/amusement. One might wonder why such “edutainment” should be placed in the art gallery rather than, say, in a museum of science or illusion. Nevertheless, in the best cases, the foregrounding, or removal, of bodily sensations that proprioceptive artworks deliver can potentially help to connect people in an increasingly digital, online, mostly audiovisual, and hence in some sense disembodied contemporary existence. These issues are discussed in the context of the works of Carsten Höller, a prolific German installation and object artist.
Therapeutic arteriogenesis by factor-decorated fibrin matrices promotes wound healing in diabetic mice
Authors: D’Amico Rosalinda , Malucelli Camilla , Uccelli Andrea , Grosso Andrea , Di Maggio Nunzia , Briquez Priscilla S , Hubbell Jeffrey A , Wolff Thomas , Gürke Lorenz , Mujagic Edin , Gianni-Barrera Roberto , Banfi Andrea
Published: September 2022

Chronic wounds in type-2 diabetic patients present areas of severe local skin ischemia despite mostly normal blood flow in deeper large arteries. Therefore, restoration of blood perfusion requires the opening of arterial connections from the deep vessels to the superficial skin layer, that is, arteriogenesis. Arteriogenesis is regulated differently from microvascular angiogenesis and is optimally stimulated by high doses of Vascular Endothelial Growth Factor-A (VEGF) together with Platelet-Derived Growth Factor-BB (PDGF-BB). Here we found that fibrin hydrogels decorated with engineered versions of VEGF and PDGF-BB proteins, to ensure protection from degradation and controlled delivery, efficiently accelerated wound closure in diabetic and obese db/db mice, promoting robust microvascular growth and a marked increase in feeding arterioles. Notably, targeting the arteriogenic factors to the intact arterio-venous networks in the dermis around the wound was more effective than the routine treatment of the inflamed wound bed. This approach is readily translatable to a clinical setting.
Hamster organotypic kidney culture model of early-stage SARS-CoV-2 infection highlights a two-step renal susceptibility
Authors: Shyfrin Sophie R , Ferren Marion , Perrin-Cocon Laure , Espi Maxime , Charmetant Xavier , Brailly Manon , Decimo Didier , Iampietro Mathieu , Canus Lola , Horvat Branka , Lotteau Vincent , Vidalain Pierre-Olivier , Thaunat Olivier , Mathieu Cyrille
Published: September 2022

Kidney pathology is frequently reported in patients hospitalized with COVID-19, the pandemic disease caused by the Severe acute respiratory coronavirus 2 (SARS-CoV-2). However, due to a lack of suitable study models, the events occurring in the kidney during the earliest stages of infection remain unknown. We have developed hamster organotypic kidney cultures (OKCs) to study the early stages of direct renal infection. OKCs maintained key renal structures in their native three-dimensional arrangement. SARS-CoV-2 productively replicated in hamster OKCs, initially targeting endothelial cells and later disseminating into proximal tubules. We observed a delayed interferon response, markers of necroptosis and pyroptosis, and an early repression of pro-inflammatory cytokines transcription followed by a strong later upregulation. While it remains an open question whether an active replication of SARS-CoV-2 takes place in the kidneys of COVID-19 patients with AKI, our model provides new insights into the kinetics of SARS-CoV-2 kidney infection and can serve as a powerful tool for studying kidney infection by other pathogens and testing the renal toxicity of drugs.
Physician–patient communication in vascular surgery: Analysis of encounters in academic practice
Authors: Willging Abbygale M , Castro Elvis , Xu Jun
Published: September 2022

Objective:

To assess physician–patient communication in vascular consults with the aim of identifying areas for improvement.

Introduction:

Shared decision-making in clinical consults can enhance patient outcomes. Its potential benefits are significant in vascular surgery, where decisions are dependent on the patient’s definition of quality of life and outcomes are influenced by significant lifestyle changes.

Methods:

In this qualitative cross-sectional study, encounters between five vascular surgeons and their patients with two asymptomatic vascular diseases were audio recorded, transcribed, and analyzed for validated sociolinguistic statistics. The nine-item shared decision-making questionnaire was used to gauge subjective patient perspective.

Results:

Physicians spent an average of 19 min and 28 s (±8:55) per consult and an average of 12 min and 7 s talking to the patient (±6:33). Physicians used formalized language about 10.3 times an encounter (±8.39), checked for understanding 6.4 times (±4.84), and asked more close-ended than open-ended questions (10.5 ± 6.15 versus 4.6 ± 2.37). Physicians accounted for 46.34% of utterances (±6%) and averaged 5.8 interruptions per encounter (±4). Patients and company accounted for 53.66% of total utterances (±6%) and averaged 10.1 clarification questions (±9.78). The average nine-item shared decision-making questionnaire Likert-type score per patient was 2.82 on a range of −3 to +3 (±0.33), with positive numbers indicating agreement. On average, patients strongly (+2) or completely (+3) agreed that physicians covered the nine criteria.

Conclusion:

The 9-item shared decision-making questionnaire data showed that patients mostly felt their physician was adequate in exhibiting shared decision-making behaviors. However, physicians asked closed-ended questions that elicited “yes/no” or brief responses, continuously interrupted patient narratives, and rarely checked for understanding from their patients. These subliminal behaviors restrict patient participation in shared decision-making and may be corrected via longitudinal intervention.
Social workers coordination in primary healthcare for patients with complex needs: A scoping review
Authors: Couturier Yves , Lanoue Sèverine , Karam Marlène , Guillette Maxime , Hudon Catherine
Published: September 2022

Introduction

Care coordination has been part of social work for some time. It has been recognized as contributing to care coordination for long-term care for the elderly and mental health but less is known about their contribution in primary care with patients with complex health and social needs. As social workers are increasingly present in primary healthcare, this scoping review aims to provide a synthesis of social workers’ coordination activities for patients with complex needs in primary healthcare.

Methods

CINAHL, Medline, Scopus, SocioIndex, Social Work Abstracts, and ProQuest databases were searched, from 2004 to 2020 for peer-reviewed literature. A thematic analysis using deductive and inductive approaches was used to conduct this scoping review.

Results

Eighteen studies on 11 different care coordination interventions were included. The care coordination activities have been classified into four categories: 1) activities that target the patient, family, and caregivers; 2) activities that target health and social care professionals and services; 3) activities that link the patient and family with health and social professionals and services; and 4) cross-cutting activities that support and enhance other activity.

Discussion

A variety of care coordination interventions conducted by social workers were identified, all of which included related but different activities. Still, the common aim is to reduce fragmentation of care. Social workers, because of their disciplinary skills characterized by linkages to nonmedical services, can make a significant contribution to the coordination of care in primary health care, in collaboration with nurses.
Clinical and MRI Donor-Site Outcomes After Autograft Harvesting From the Medial Trochlea for Talar Osteochondral Lesions: Minimum 5-Year Clinical Follow-up
Authors: Guo Changjun , Li Xingchen , Zhu Yuan , Yang Chonglin , Xu Xiangyang
Published: September 2022

Background:

Autologous osteochondral transplantation (AOT) is a treatment option for large or cystic osteochondral lesions of the talus (OLTs), with promising clinical results. However, donor-site morbidity (DSM) has always been a concern with this procedure.

Purpose:

To investigate the clinical and radiological outcomes of autograft harvesting from the medial trochlea for OLTs.

Study Design:

Case series; Level of evidence, 4.

Methods:

A total of 46 consecutive patients were included after AOT procedures for OLTs, with donor autografts (single or double plugs) harvested from the medial trochlea of the ipsilateral knee. Lysholm scores were collected postoperatively at 12-month intervals to assess clinical outcomes. Postoperative magnetic resonance imaging (MRI) was used to assess the donor site using the MOCART (magnetic resonance observation of cartilage repair tissue) score. DSM was evaluated at 12-month intervals. Statistical analysis was performed to compare patients treated with single-plug and double-plug AOT procedures and establish whether there was any correlation between MOCART and Lysholm scores.

Results:

The mean follow-up period was 98.3 months (range, 67-144 months). The Lysholm scores for all patients were 92.5 ± 6.1 and 99.9 ± 0.2 at the 12-month and final follow-ups, respectively. MRI of the donor sites was taken at an average of 93.8 ± 20.5 (range, 61-141) months postoperatively, and the mean MOCART score was 76.2 ± 4.9. The overall incidence of DSM in this study was 4.3% at 12 months, postoperatively, which decreased to 0% at the 24-month follow-up. There was no significant difference in either the Lysholm score ( P = .16) or the MOCART score ( P = .83) between the single-plug and double-plug groups at the final follow-up. There were no significant correlations between MOCART and Lysholm scores and patient age, number of grafts, or body mass index.

Conclusion:

According to the study findings, the DSM of donor autografts harvested from the medial trochlea was low, and the number (single or double) of grafts did not affect the functional outcome.
Count Your Life by Smiles and Tears: An Integrative Review on Resilience and Growing Older
Authors: Beeris Chloe , Niemeijer Alistair , Machielse Anja
Published: September 2022

The concept of “resilience” is considered helpful in understanding how people navigate adversities typical to later life. It is also a concept of growing interest internationally in research and in social policy and (social) practice. This article employs an integrative review methodology to explore current trends in theoretical and empirical research on resilience. A total of 25 quantitative and qualitative studies from 2011 to 2020 are included in this review. Findings indicate how the reviewed studies typically define resilience from three perspectives: resource-based, outcome-based, and process-based perspectives of resilience. In the results of the same studies, the resource-based and outcome-based perspectives are elaborated upon while detailed results from a process-based perspective are lacking. Additionally, even though adversity is recognized as a key element in conceptualizing resilience, it is scarcely defined if defined at all in the reviewed studies. Further research is recommended in this article to contribute to a realistic and encouraging narrative on growing older in social policy and (social) practice.
Pioneering COVID-19 Pandemic Partnerships: Federally Qualified Health Centers and Geriatric Workforce Enhancement Programs Work Together to Care for Diverse Underserved Older Adults
Authors: Gibbs Lisa , Rousseau Julie , Tumosa Nina , Gupta Roopali , Olsen Bonnie , Faul Anna , Reichstadt Jennifer , Cotton Samantha , Sivers-Teixiera Theresa , Saville Neika , Lee Jung-Ah
Published: September 2022

Background: The COVID-19 pandemic disproportionately affected populations served by Federally Qualified Health Centers (FQHCs), with high morbidity and mortality rates in ethnic minority older adults. In response to this pandemic, academic geriatric medicine teams through federally funded Geriatric Workforce Enhancement Program (GWEP) with FQHC partnership implemented new initiatives to improve the care for vulnerable older adults. Objectives: To describe how four FQHC/GWEP teams collaborated in caring for diverse communities of older adults during the pandemic. Methods: Four GWEPs have addressed pandemic response efforts with their respective FQHC partners. These collaborations to meet the increasing numbers of older adults seeking services, and the rising disparities exacerbated during the pandemic are delineated. Results: FQHC/GWEP partnerships enabled access to care, whether in-person or virtually to serve unmet needs of underserved older adults during the pandemic. Partnerships promoted COVID-19 education, testing, and vaccinations. Most FQHCs faced severe staffing shortages, and the digital divide challenged patients with barriers. GWEPs provided direct care, created educational materials, and developed telehealth programs. These partnerships addressed social determinants of health gaps caused by the pandemic. Conclusion: The findings demonstrate that strong partnerships between GWEPs and FQHCs mitigate health inequities for vulnerable ethnic minority and rural older adults during pandemic crises.
Net Worth Poverty and Child Development
Authors: Gibson-Davis Christina , Keister Lisa A. , Gennetian Lisa A. , Lowell Warren
Published: September 2022

The authors investigate whether net worth poverty (NWP) reduces children’s well-being. NWP—having wealth (assets minus debts) less than one fourth of the federal poverty line—is both theoretically and empirically distinct from income poverty (IP) and is the modal form of poverty among children. Data come from the Panel Study of Income Dynamics and its Child Development Supplement on children ages 3 to 17 years observed between 2002 and 2019. The authors use linear mixed-effects models to investigate the associations among NWP, IP, and four cognitive and behavioral outcomes. NWP reduces children’s cognitive scores and was associated with increases in both problem behavior scores. Negative associations for NWP are similar in magnitude to those found for IP. Much of the NWP effect operates through asset deprivation rather than high debt. The results illustrate the potential risks many children, previously overlooked in studies of IP, face because of wealth deprivation.
Mutations in the Spliceosome Component prp-6 and Overexpression of cdh-5 Suppress Axon Guidance Defects of cdh-4 Mutants in Caenorhabditis elegans
Authors: Aburegeba Zina , Pan Jie , Hutter Harald
Published: September 2022

During nervous system development, axons must navigate to specific target areas. In Caenorhabditis elegans, the cadherin CDH-4 is required for ventral nerve cord axonal navigation, and dorsal nerve cord fasciculation. How CDH-4 mediates axon navigation and fasciculation is currently unknown. To identify genes acting together with cdh-4, we isolated mutants suppressing the axon guidance defects of cdh-4 mutants. These suppressors showed partial suppression of axonal defects in the dorsal and ventral nerve cords seen in cdh-4 mutants. We identified one suppressor gene, prp-6, which encodes a component of the spliceosome. Complete loss-of-function alleles of prp-6 are lethal, suggesting that the mutation isolated in our suppressor screen is a partial loss-of-function allele. A previous study found that RNAi-induced suppression of prp-6 leads to changes in the expression of several 100 genes including the cadherin cdh-5. We found that overexpression of cdh-5 mimics the suppression seen in prp-6 mutants, suggesting that CDH-5 can partially compensate for the loss of CDH-4.
Revision Anterior Cruciate Ligament Reconstruction and Increased Tibial Slope: When to Perform a Slope-Altering High Tibial Osteotomy
Authors: Lucidi Gian Andrea , Zsidai Bálint , Winkler Philipp W. , Godshaw Brian M. , Hughes Jonathan D. , Musahl Volker
Published: September 2022

Background:

Slope-correcting high tibial osteotomy (HTO) is gaining popularity for mitigating the impact of posterior tibial slope (PTS) on graft failure in patients requiring revision anterior cruciate ligament (ACL) reconstruction surgery. Biomechanical and clinical studies have demonstrated that PTS reduction results in decreased graft forces and satisfactory patient outcomes, making it an important technique in the setting of complex revision ACL reconstruction (ACL-R).

Indications:

Slope-correcting HTO can be performed for the management of recurrent knee instability after ACL-R due to a high PTS of 12° or greater.

Technique Description:

A 3- to 4-inch incision is made along the tibia using an anteromedial approach, and the exposed patellar tendon is protected using a retractor. The anterior compartment is exposed by an incision in the tibialis anterior fascia, followed by elevation of the tibialis anterior and placement of a Hohmann retractor. Subperiosteal elevation of the medial collateral ligament (MCL) is performed on the medial side of the tibial tubercle. The position of eventual screw fixation is marked, and a straight tubercle osteotomy is performed without anteriorization, leaving a freely exposed proximal tibia. Two K-wires are used to mark the location of the osteotomy. Soft tissue structures are protected with Hohmann retractors on both sides while using an oscillating saw to perform the osteotomy. A few degrees (1°-3°) of overcorrection are preferred. The osteotomy is completed, retaining 1cm of posterior hinge. The wedge is removed and reduced by hyperextending the knee under gentle manual traction. Pre-contoured, low-profile plates with locking screws are placed, with 3 screws proximally and another 3 distally. During concurrent ACL-R, the screws should leave room for drilling of the ACL tibial tunnel.

Results:

Studies investigating the effects of slope-correcting HTO concurrent to revision ACL-R have reported reduced anterior tibial translation and rotatory knee instability, improved patient-reported outcomes, and a reduction in graft failure risk.

Description/Conclusion:

Slope-reducing HTO is an essential technique in the arsenal of complex ACL surgeons aiming to correct the detrimental effect of an increased PTS on ACL graft integrity in the setting of revision ACL-R.
Validity of the Early Functional Ability scale (EFA) among critically ill patients undergoing early neurological rehabilitation
Authors: Boltzmann Melanie , Schmidt Simone B. , Gutenbrunner Christoph , Krauss Joachim K. , Höglinger Günter U. , Weimar Christian , Rollnik Jens D.
Published: September 2022

Background

A reliable assessment of the functional abilities of patients after severe brain damage is crucial for valid prognostication and treatment decisions, but most clinical scales are of limited use among this specific group of patients.

Aim

The present study investigates the usefulness of the Early Functional Ability (EFA) scale, which determines the functional abilities of severely impaired patients.

Methods

Critically ill patients consecutively admitted to early neurological rehabilitation were screened for eligibility. We assessed the correlation between the EFA scale and (i) the Early Rehabilitation Barthel Index (ERBI), and (ii) the Coma Recovery Scale-Revised (CRS-R). The 1-year outcome on the Glasgow Outcome Scale-extended (GOSE) was used to examine the predictive validity. Demographical and medical variables were entered into univariate and multivariate binary regression models to identify independent predictors of 1-year outcome.

Results

Two hundred fifty-seven patients (168 men) with a median age of 62 years (IQR = 51–75) were enrolled. The correlation of the EFA scale with the CRS-R was high but low with the ERBI upon admission. Multivariate regression analysis yielded the vegetative subscale of the EFA scale as the only independent predictor for the 1-year outcome of patients admitted to early neurological rehabilitation.

Conclusions

This study shows a high correlation of the EFA scale with the CRS-R but a weak correlation with the ERBI in patients with low functional abilities. With improving patient abilities, these correlations were partly reversed. Thus, the EFA scale is a useful tool to assess the functional abilities and the prognosis of critically ill patients adequately and may be more feasible than other scales.
A qualitative study of the impact of peer support on women’s mental health treatment experiences during the perinatal period
Authors: Rice Chloe , Ingram Emma , O’Mahen Heather
Published: September 2022

Background

Perinatal mental health problems are prevalent, affecting up to 20% of women However, only 17–25% receive formal support during the perinatal period. In this qualitative study, we sought to examine women’s experiences with peer support for mental health problems during the perinatal period.

Methods

Semi-structured interviews and focus groups were conducted with twenty-five mothers from the UK who had utilised peer support for a perinatal mental health problem. Data was analysed using thematic analysis.

Results

Seven major themes were identified in women’s help seeking process and experience of peer support. These included; perinatal specific precipitating factors that contributed to their mental health problems, barriers in the form of unhelpful professional responses, feelings of isolation, acceptance of the problem and need to actively re-seek support, finding support either through luck or peer assistance.

Conclusion

Peer support showed promise as an effective means to reduce perinatal mental health difficulties; either as a form of formal support or as an adjunct to formal support. The results highlight ways to improve perinatal women’s access to mental health support through peer-based mechanisms.
Effects of a fixed nurse team in the orthopaedic surgery operating room on work efficiency and patient outcomes: a propensity score-matched historically controlled study
Authors: Zhong Huaying , Zhou Limin , Liao Shaoling , Tang Jing , Yue Liqun , Mo Meizhen , Zhong Yiyue
Published: September 2022

Background

The work value of operating room (OR) nurses is directly reflected in nursing quality. However, evaluating the work value of these nurses has not been sufficiently investigated. This study evaluated the effects of a fixed nurse team (FNT) in an orthopaedic surgery OR on work efficiency and patient outcomes.

Methods

A propensity score-matched historically controlled study conducted from 1 July 2015 to 30 June 2018 was used to investigate the difference in nursing quality between an FNT period and a non-FNT period in the orthopaedic surgery OR at a tertiary care hospital in China. The primary outcome was surgical site infections (SSIs) during in-hospital visits, and as a secondary outcome, other nursing-sensitive quality indicators were assessed with historically controlled data. A multifactor logistic regression model was constructed to examine the primary outcome differences between the FNT and non-FNT periods before and after propensity score matching.

Results

In total, 5365 patients and 33 nurses were included in the final analysis. The overall SSI rate was 2.1% (110/5365; the non-FNT period 2.6% [64/2474], the FNT period 1.6% [46/2891]). A lower incidence of SSIs in patients (odds ratio 0.57, 95% CI 0.36 to 0.88, P=0.013), a lower turnover time of the surgical procedure (odds ratio 0.653, 95% CI 0.505 to 0.844, P<0.001), and improvement in surgeon satisfaction (odds ratio 1.543, 95% CI 1.039 to 2.292, P=0.031), were associated with the FNT period compared with the non-FNT period. However, we did not find significant differences between the FNT period and the non-FNT period in terms of the other indicators.

Conclusions

The presence of an FNT in an OR reduces the incidence of SSIs in surgical patients and the turnover time of surgical procedures and improves surgeon satisfaction. Further implementation of an advanced-practice nurse model with nurse specialists is encouraged.
Investigation of Toxoplasma infection in zoo animals using multispecies ELISA and GRA7 nested PCR
Authors: Liu Ru-Min , Huang Wei-Hsiang , Wang Shang-Lin , Wang Sin-Ling , Huang Pei-Yun , Lien Chen-Yeh , Lai Yen-Hsueh , Wang Pao-Jung , Wu Li-Hsin , Liao Albert Taiching
Published: September 2022

Background

Toxoplasma is an obligate intracellular protozoan that causes an important zoonotic disease with a worldwide distribution. Felids are the definitive hosts of this parasite, while virtually all warm-blooded animals, including birds, serve as intermediate hosts. Four ring-tailed lemurs (Lemur catta) in the Taipei Zoo died of acute Toxoplasma infection in June 2019. Since then, Toxoplasma has occasionally been identified in this Zoo during necropsy of dead animals and PCR of animal blood samples. Therefore, a general survey of Toxoplasma infection in animals in the Zoo seems to be needed.

Methods and results

An indirect multispecies ELISA was used for the first time to screen for Toxoplasma infection in 326 serum samples collected from 75 species of animals. The infection rate of Toxoplasma was 27% (88/326). A commercial latex agglutination (LAT) assay was used to re-examine the samples with doubtful and uncertain ELISA results (151 samples from 42 species). The infection rate increased to 36.2% (118/326), and the indirect multispecies ELISA appeared to be applicable to 31 of 75 species animals included in this study. Nested PCR assays targeting the dense granule protein 7 (GRA7) gene and B1 gene were also used to detect Toxoplasma in DNA samples extracted from 10 liver or blood specimens from 8 animals. GRA7 gene fragments were amplified from 8 samples from 7 animals, while B1 gene fragments were amplified from only 4 samples from 4 animals. From the B1 nested PCR and the sequence data of GRA7 fragments amplified from infectious specimens, the animals in the Zoo were speculated to have been infected by at least three different Toxoplasma variants.

Conclusions

According to the serological investigation, we speculated that over one-third (36.2%) of animals in Taipei Zoo presented the infection of Toxoplasma, and the indirect multispecies ELISA we used can be applied to detect Toxoplasma infection in 31 animal species included in this study. Sequence analysis revealed that at least three Toxoplasma variants were infecting the animals of Taipei Zoo.
Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
Authors: Leonardo Leo , Kenangalem Enny , Poespoprodjo Jeanne R. , Noviyanti Rintis , Price Ric N. , Anstey Nicholas M. , Minigo Gabriela , Kho Steven
Published: September 2022

Background

Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.

Methods

Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia.

Results

The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria.

Conclusion

Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.
Attention-optimized DeepLab V3 + for automatic estimation of cucumber disease severity
Authors: Li Kaiyu , Zhang Lingxian , Li Bo , Li Shufei , Ma Juncheng
Published: September 2022

Background

Automatic and accurate estimation of disease severity is critical for disease management and yield loss prediction. Conventional disease severity estimation is performed using images with simple backgrounds, which is limited in practical applications. Thus, there is an urgent need to develop a method for estimating the disease severity of plants based on leaf images captured in field conditions, which is very challenging since the intensity of sunlight is constantly changing, and the image background is complicated.

Results

This study developed a simple and accurate image-based disease severity estimation method using an optimized neural network. A hybrid attention and transfer learning optimized semantic segmentation model was proposed to obtain the disease segmentation map. The severity was calculated by the ratio of lesion pixels to leaf pixels. The proposed method was validated using cucumber downy mildew, and powdery mildew leaves collected under natural conditions. The results showed that hybrid attention with the interaction of spatial attention and channel attention can extract fine lesion and leaf features, and transfer learning can further improve the segmentation accuracy of the model. The proposed method can accurately segment healthy leaves and lesions (MIoU = 81.23%, FWIoU = 91.89%). In addition, the severity of cucumber leaf disease was accurately estimated (R2 = 0.9578, RMSE = 1.1385). Moreover, the proposed model was compared with six different backbones and four semantic segmentation models. The results show that the proposed model outperforms the compared models under complex conditions, and can refine lesion segmentation and accurately estimate the disease severity.

Conclusions

The proposed method was an efficient tool for disease severity estimation in field conditions. This study can facilitate the implementation of artificial intelligence for rapid disease severity estimation and control in agriculture.
The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots
Authors: Yuan Shenli , Huang Tao , Bao Ziyou , Wang Shiyu , Wu Xinyue , Liu Jiang , Liu Hongbin , Chen Zi-Jiang
Published: September 2022

Background

The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspots in mammals. Beyond histone methylation, H3 lysine 9 acetylation (H3K9ac) is also greatly enriched at recombination hotspots. Previous work has indicated the potential cross-talk between H3K4me3 and H3K9ac at recombination hotspots, but it is still unknown what molecular mechanisms mediate the cross-talk between the two histone modifications at hotspots or how the cross-talk regulates homologous recombination in meiosis.

Results

Here, we find that the histone methylation reader ZCWPW1 is essential for maintaining H3K9ac by antagonizing HDAC proteins’ deacetylation activity and further promotes chromatin openness at recombination hotspots thus preparing the way for homologous recombination during meiotic double-strand break repair. Interestingly, ectopic expression of the germ-cell-specific protein ZCWPW1 in human somatic cells enhances double-strand break repair via homologous recombination.

Conclusions

Taken together, our findings provide new insights into how histone modifications and their associated regulatory proteins collectively regulate meiotic homologous recombination.