bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy
Authors: Lee A Young , Choi Jinyoung , Lee Sang Un , Kim Chul Woo , Hwang Daniel Duck-Jin
Published: February 2024

This study investigated the changes in the ganglion cell complex (GCC) of patients with acute central serous chorioretinopathy (CSC) following focal laser photocoagulation (FLP) and sought to determine its correlation with visual acuity (VA). Our retrospective study was conducted on 30 patients diagnosed with acute CSC between January 2015 and April 2022, who underwent FLP within 3 months of symptom onset. The study assessed GCC changes by measuring the thickness of its inner retinal layers—retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) using optical coherence tomography (OCT). GCC thickness was compared between the affected and unaffected eyes and a healthy control group. VA was also assessed at baseline and at 1, 3, and 6 months post-treatment. VA showed significant improvement from 0.20 ± 0.14 at baseline to 0.10 ± 0.12 logMAR at 6 months post-treatment (p = 0.003). There was no significant change in GCC thickness over the 6-month period. No significant differences in GCC thickness were observed when comparing CSC eyes with fellow eyes or with normal controls at any time point. Final VA was significantly related only to baseline VA, with no correlation found with other factors, including RNFL, GCL, and IPL thickness. In summary, for patients with acute CSC undergoing FLP, our findings indicate that there is no significant change in GCC thickness detectable by OCT before and after the resolution of subretinal fluid (SRF), despite improvements in VA post-laser treatment. This suggests that any potential impact of FLP on GCC thickness may be minimal and not discernible with the current measurement methods, such as OCT, emphasizing that VA improvements may be primarily associated with alterations in the outer retina rather than the inner retina. Further studies with extended follow-up durations are warranted to evaluate any potential long-term changes in GCC.
New Perspectives of Therapies in Osteogenesis Imperfecta—A Literature Review
Authors: Dinulescu Alexandru , Păsărică Alexandru-Sorin , Carp Mădălina , Dușcă Andrei , Dijmărescu Irina , Pavelescu Mirela Luminița , Păcurar Daniela , Ulici Alexandru
Published: February 2024

(1) Background: Osteogenesis imperfecta (OI) is a rare skeletal dysplasia characterized as a heterogeneous disorder group with well-defined phenotypic and genetic features that share uncommon bone fragility. The current treatment options, medical and orthopedic, are limited and not efficient enough to improve the low bone density, bone fragility, growth, and mobility of the affected individuals, creating the need for alternative therapeutic agents. (2) Methods: We searched the medical database to find papers regarding treatments for OI other than conventional ones. We included 45 publications. (3) Results: In reviewing the literature, eight new potential therapies for OI were identified, proving promising results in cells and animal models or in human practice, but further research is still needed. Bone marrow transplantation is a promising therapy in mice, adults, and children, decreasing the fracture rate with a beneficial effect on structural bone proprieties. Anti-RANKL antibodies generated controversial results related to the therapy schedule, from no change in the fracture rate to improvement in the bone mineral density resorption markers and bone formation, but with adverse effects related to hypercalcemia. Sclerostin inhibitors in murine models demonstrated an increase in the bone formation rate and trabecular cortical bone mass, and a few human studies showed an increase in biomarkers and BMD and the downregulation of resorption markers. Recombinant human parathormone and TGF-β generated good results in human studies by increasing BMD, depending on the type of OI. Gene therapy, 4-phenylbutiric acid, and inhibition of eIF2α phosphatase enzymes have only been studied in cell cultures and animal models, with promising results. (4) Conclusions: This paper focuses on eight potential therapies for OI, but there is not yet enough data for a new, generally accepted treatment. Most of them showed promising results, but further research is needed, especially in the pediatric field.
Morbidity among Adolescent Hypnotic Drug Users in Norway: An Observational Population-Based Study
Authors: Sharikabad Mohammad Nouri , Skurtveit Svetlana , Sommerschild Hilchen Thode , Olsen Kristine , Hartz Ingeborg , Wesselhoeft Rikke , Hjellvik Vidar , Hauge Lars Johan , Handal Marte
Published: February 2024

We have previously shown that the use of hypnotic drugs increased among young Scandinavians during 2012–2018. This study aimed to explore psychiatric and somatic morbidity among adolescent hypnotic drug users in a cohort study of 13–17-year-old individuals during 2008–2018 in Norway. Data sources were (i) prescription data from the Norwegian Prescription Database linked to specialist health care diagnoses from the Norwegian Patient Registry and (ii) sleep disorder diagnoses from the Primary Health Care Database. Hypnotic drugs were defined as the sedative antihistamine alimemazine and the ATC group “Hypnotics and Sedatives” (N05C), excluding midazolam. In 2017, 2519 girls (16.5/1000) and 1718 boys (10.7/1000) were incident (new) users of hypnotic drugs. Most of these new users (82% of girls, 77% of boys) were referred to secondary health care, where the most frequent diagnoses were mental and behavioral disorders (51.8% of girls, 46.2% of boys), while only 3.2% received a specific sleep disorder diagnosis. The most common mental and behavioral disorders were “Neurotic stress-related disorders” among girls (27.4%) and “Behavioral and emotional disorders” among boys (23.6%). In conclusion, the trend of increasing hypnotic drug use among adolescents reflects the initiation of hypnotic drugs in a subgroup of the population with a higher disease burden, mainly due to psychiatric disorders, than the general population.
Cultivation of Chroococcidiopsis thermalis Using Available In Situ Resources to Sustain Life on Mars
Authors: Fais Giacomo , Casula Mattia , Sidorowicz Agnieszka , Manca Alessia , Margarita Valentina , Fiori Pier Luigi , Pantaleo Antonella , Caboni Pierluigi , Cao Giacomo , Concas Alessandro
Published: February 2024

The cultivation of cyanobacteria by exploiting available in situ resources represents a possible way to supply food and oxygen to astronauts during long-term crewed missions on Mars. Here, we evaluated the possibility of cultivating the extremophile cyanobacterium Chroococcidiopsis thermalis CCALA 050 under operating conditions that should occur within a dome hosting a recently patented process to produce nutrients and oxygen on Mars. The medium adopted to cultivate this cyanobacterium, named Martian medium, was obtained using a mixture of regolith leachate and astronauts’ urine simulants that would be available in situ resources whose exploitation could reduce the mission payload. The results demonstrated that C. thermalis can grow in such a medium. For producing high biomass, the best medium consisted of specific percentages (40%vol) of Martian medium and a standard medium (60%vol). Biomass produced in such a medium exhibits excellent antioxidant properties and contains significant amounts of pigments. Lipidomic analysis demonstrated that biomass contains strategic lipid classes able to help the astronauts facing the oxidative stress and inflammatory phenomena taking place on Mars. These characteristics suggest that this strain could serve as a valuable nutritional resource for astronauts.
Can a Total Knee System Providing 1 mm Increment of Polyethylene Insert Thickness Offer a Clinical Benefit?
Authors: Lee Dhong-Won , Jang Hyuk-Jin , Kim Man-Soo , Choi Keun-Young , Hong Sung-An , In Yong
Published: February 2024

Background and Objectives: The purpose of this study was to compare clinical outcomes and polyethylene (PE) insert thickness between total knee arthroplasty (TKA) systems providing 1 mm and 2 mm increments. Materials and Methods: In this randomized controlled trial, 50 patients (100 knees) undergoing same-day or staggered bilateral TKA were randomized to receive a TKA system providing 1 mm increments in one knee (1 mm group) and a TKA system providing 2 mm increments in the other knee (2 mm group). At 2 years postoperatively, Knee Society Score (KSS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, Forgotten Joint Score (FJS), range of motion (ROM), and insert thicknesses were compared between the groups. Results: A total of 47 patients (94 knees) participated in follow-up analysis. In each group, patient-reported outcomes improved significantly after TKA (all, p < 0.05). There were no significant differences in patient-reported outcomes. The mean ROM was not significantly different between groups at preoperative and 2-year points. The rate of postoperative flexion contracture ≥ 5° was 2.1% and 4.3%, and the rate of postoperative recurvatum ≥ 5° was 4.3% and 2.1% in the 1 mm group and 2 mm, respectively (all, p = 1.000). Mean insert thickness was significantly thinner in the 1 mm group than the 2 mm group (p = 0.001). The usage rate of a thick insert (≥14 mm) was 12.7% and 38.3% in the 1 mm group and 2 mm group (p = 0.005). Conclusions: The use of a TKA system providing 1 mm PE insert thickness increments offered no clinical benefit in terms of patient reported outcomes over systems with 2 mm increments at 2 years of follow-up. However, the TKA system with 1 mm increments showed significantly thinner PE insert usage. As a theoretical advantage of 1 mm increments has yet to be proven, the mid- to long-term effects of thinner PE insert usage must be determined.
Dangerous and Unprofessional Content: Anarchist Dreams for Alternate Nursing Futures
Authors: Dillard-Wright Jess , Jenkins Danisha
Published: February 2024

Professionalized nursing and anarchism could not be more at odds. And yet, if nursing wishes to have a future in the precarious times in which we live and die, the discipline must take on the lessons that anarchism has on offer. Part love note to a problematic profession we love and hate, part fever dream of what could be, we set out to think about what nursing and care might look like after it all falls down, because it is all falling down. Drawing on alternate histories, alternate visions of nursing history, we imagine what nursing values would look like, embracing anarchist principles. We consider examples of community survival, mutual aid, and militant joy as strategies to achieve what nursing could be if nurses put an end to their cop shit, shrugging off their shroud of white cisheteropatriarchal femininity that manifests as professionalism and civility. We conclude with a call to action and a plan for skill-building because this can all be different.
Precision Agriculture Applied to Harvesting Operations through the Exploitation of Numerical Simulation
Authors: Cheli Federico , Abdelaziz Ahmed Khaled Mohamed , Arrigoni Stefano , Paparazzo Francesco , Pezzola Marco
Published: February 2024

When it comes to harvesting operations, precision agriculture needs to consider both combine harvester technology and the precise execution of the process to eliminate harvest losses and minimize out-of-work time. This work aims to propose a complete control framework defined by a two-layer-based algorithm and a simulation environment suitable for quantitative harvest loss, time, and consumption analyses. In detail, the path-planning layer shows suitable harvesting techniques considering field boundaries and irregularities, while the path-tracking layer presents a vision-guided Stanley Lateral Controller. In order to validate the developed control framework, challenging driving scenarios were created using IPG-CarMaker software to emulate wheat harvesting operations. Results showed the effectiveness of the designed controller to follow the reference trajectory under regular field conditions with zero harvest waste and minimum out-of-work time. Whereas, in presence of harsh road irregularities, the reference trajectory should be re-planned by either selecting an alternative harvesting method or overlapping the harvester header by some distance to avoid missing crops. Quantitative and qualitative comparisons between the two harvesting techniques as well as a relationship between the level of irregularities and the required overlap will be presented. Eventually, a Driver-in-the-loop (DIL) framework is proposed as a methodology to compare human and autonomous driving.
Detection and Localization of Small Moving Objects in the Presence of Sensor and Platform Movement
Authors: Cuellar Adam , Mahalanobis Abhijit , Renshaw C. Kyle , Mikhael Wasfy
Published: February 2024

In this paper, we address the challenge of detecting small moving targets in dynamic environments characterized by the concurrent movement of both platform and sensor. In such cases, simple image-based frame registration and optical flow analysis cannot be used to detect moving targets. To tackle this, it is necessary to use sensor and platform meta-data in addition to image analysis for temporal and spatial anomaly detection. To this end, we investigate techniques that utilize inertial data to enhance frame-to-frame registration, consistently yielding improved detection outcomes when compared against purely feature-based techniques. For cases where image registration is not possible even with metadata, we propose single-frame spatial anomaly detection and then estimate the range to the target using the platform velocity. The behavior of the estimated range over time helps us to discern targets from clutter. Finally, we show that a KNN classifier can be used to further reduce the false alarm rate without a significant reduction in detection performance. The proposed strategies offer a robust solution for the detection of moving targets in dynamically challenging settings.
Skeleton-Based Activity Recognition for Process-Based Quality Control of Concealed Work via Spatial–Temporal Graph Convolutional Networks
Authors: Xiao Lei , Yang Xincong , Peng Tian , Li Heng , Guo Runhao
Published: February 2024

Computer vision (CV)-based recognition approaches have accelerated the automation of safety and progress monitoring on construction sites. However, limited studies have explored its application in process-based quality control of construction works, especially for concealed work. In this study, a framework is developed to facilitate process-based quality control utilizing Spatial–Temporal Graph Convolutional Networks (ST-GCNs). To test this model experimentally, we used an on-site collected plastering work video dataset to recognize construction activities. An ST-GCN model was constructed to identify the four primary activities in plastering works, which attained 99.48% accuracy on the validation set. Then, the ST-GCN model was employed to recognize the activities of three extra videos, which represented a process with four activities in the correct order, a process without the activity of fiberglass mesh covering, and a process with four activities but in the wrong order, respectively. The results indicated that activity order could be clearly withdrawn from the activity recognition result of the model. Hence, it was convenient to judge whether key activities were missing or in the wrong order. This study has identified a promising framework that has the potential to the development of active, real-time, process-based quality control at construction sites.
“Pass the Genetic Scalpel”: A Comprehensive Review of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) in Urological Cancers
Authors: Yim Arthur , Alberto Matthew , Herold Marco , Woon Dixon , Ischia Joseph , Bolton Damien
Published: February 2024

Introduction: Urological cancers account for a significant portion of cancer diagnoses and mortality rates worldwide. The traditional treatment options of surgery and chemoradiation can have significant morbidity and become ineffective in refractory disease. The discovery of the CRISPR system has opened up new avenues for cancer research by targeting specific genes or mutations that play a role in cancer development and progression. In this review, we summarise the current state of research on CRISPR in urology and discuss its potential for improving the diagnosis and treatment of urological cancers. Methods: A comprehensive literature search was conducted on databases including PubMed, Embase, and Cochrane Library. The keywords included CRISPR and urology OR prostate OR renal OR bladder OR testicular cancer. Results: CRISPR has been used extensively in a preclinical setting to identify and target genes in prostate cancer, including AR, NANOG, ERβ, TP53, PTEN, and PD-1. Targeting PRRX2 and PTEN has also been shown to overcome enzalutamide and docetaxel resistance in vitro. In bladder cancer, CBP, p300, hTERT, lncRNA SNGH3, SMAD7e, and FOXA1 have been targeted, with HNRNPU knockout demonstrating tumour inhibition, increased apoptosis and enhanced cisplatin sensitivity both in vitro and in vivo. Renal cancer has seen CRISPR target VHL, TWIST1, PTEN, and CD70, with the first in-human clinical trial of Anti-CD70 CAR T cell therapy showing an excellent safety profile and durable oncological results. Lastly, testicular cancer modelling has utilised CRISPR to knockout FLNA, ASH2L, HMGB4, CD24, and VIRMA, with NAE1 found to be over-expressed in cisplatin-resistant germ cell colonies. Conclusions: CRISPR is a cutting-edge technology that has been used extensively in the pre-clinical setting to identify new genetic targets, enhance drug sensitivity, and inhibit cancer progression in animal models. Although CAR T cell therapy has shown promising results in RCC, CRISPR-based therapeutics are far from mainstream, with further studies needed across all urological malignancies.
Does Autologous Blood Injection Following Dextranomer/Hyaluronic Acid Copolymer Implantation in Treating Vesicoureteral Reflux Affect the Microsphere Particle Leakage?
Authors: Kamran Hooman , Tafazoli Nooshin , Eftekharzadeh Sahar , Hekmati Pooya , Arshadi Hamid , Kajbafzadeh Abdol-Mohammad
Published: February 2024

Objectives: It has been shown that concomitant autologous blood and dextranomer/hyaluronic acid (Deflux®) injection, hydrodistension autologous blood injection technique (HABIT), had a better mound preservation and treatment success compared to the hydrodistension injection technique (HIT) in vesicoureteral reflux (VUR) correction. In this study, we aimed to show microscopically whether the concomitant injection of autologous blood decreases the leakage of Deflux® particles. Methods: Children with VUR who underwent HIT or HABIT between March 2020 and January 2023 were enrolled. Following the completion of the procedure on each ureter, the bladder was irrigated for 3 to 5 min, and the retrieved sample of irrigation fluid was evaluated for dextranomer particle count as “immediate leakage”. A Foley catheter was placed, and a urine sample after 12 h was collected as “early leakage”. Results: A total of 86 children with a median age of 3.0 years (interquartile range = 4.6) were included. Overall, 66 patients underwent HABIT, and 20 children underwent HIT. Rupture was observed in five patients during the procedure, and re-injection was conducted successfully in these cases. Immediate, early, and total particle leakage in the first 12 h of the injection were significantly less in the HABIT group compared to the HIT group. In the regression analysis, only the injection technique (HIT/HABIT) and rupture were significantly associated with the total particle leakage in the first 12 h. Conclusions: Immediate injection of autologous blood into the mound following an endoscopic correction of VUR in children is associated with significantly less Deflux® particle leakage from the injection site regardless of the VUR grade. We hypothesize that a concomitant blood injection into the Deflux® mound will create a blood clot while the needle is kept in situ and help to stabilize the mound and decrease treatment failure by minimizing particle leakage from the injection site.
Determinants of Immunovirological Response among Children and Adolescents Living with HIV-1 in the Central Region of Cameroon
Authors: Dobseu Soudebto Rodolphe Steven , Fokam Joseph , Kamgaing Nelly , Fainguem Nadine , Ngoufack Jagni Semengue Ezechiel , Tommo Tchouaket Michel Carlos , Kamgaing Rachel , Nanfack Aubin , Bouba Yagai , Yimga Junie , Chenwi Ambe Collins , Gouissi Hyacinthe , Efakika Gabisa Jeremiah , Nnomo Zam Krystel , Nka Alex Durand , Sosso Samuel Martin , Halle-Ekane Gregory-Edie , Okomo Marie-Claire , Ndjolo Alexis
Published: February 2024

About 90% of new HIV-1 infections in children occur in sub-Saharan Africa, where treatment monitoring remains suboptimal. We sought to ascertain factors associated with immunovirological responses among an ART-experienced paediatric population in Cameroon. A laboratory-based and analytical study was conducted from January 2017 throughout December 2020 wherein plasma viral load (PVL) analyses and CD4 cell counts were performed. Viral suppression (VS) was defined as PVL < 1000 copies/mL and immunological failure (IF) as CD4 < 500 cells/µL for participants ≤5 years and CD4 < 250 cells/µL for those >5 years; p < 0.05 was considered statistically significant. Overall, 272 participants were enrolled (median age: 13 [9–15.5] years; 54% males); median ART duration 7 [3–10] years. Globally, VS was achieved in 54.41%. VS was 56.96% in urban versus 40.48% in rural areas (p = 0.04). IF was 22.43%, with 15.79% among participants ≤5 years and 22.92% among those >5 years (p = 0.66). IF was 20.43% in urban versus 33.33% in rural areas (p = 0.10). Following ART, IF was 25.82% on first-line (non-nucleoside reverse transcriptase inhibitors; NNRTI-based) versus 10.17% on second-line (protease inhibitor-based) regimens (p = 0.01). Interestingly, IF was 7.43% among virally suppressed versus 40.32% among virally unsuppressed participants (p < 0.0001). A low VS indicates major challenges in achieving AIDS’ elimination in this paediatric population, especially in rural settings and poor immune statuses. Scaling up NNRTI-sparing regimens alongside close monitoring would ensure optimal therapeutic outcomes.
A Comparative Analysis of the Four Draft Constitutions Published Before the Romanian Constitution of 1923
Sacro-sanctae Scientiae
Indepingibilis Imago (1700)
Authors:   Faculty of History and Philosophy, Babeş-Bolyai University, Cluj-Napoca, Mureșan Marius
Published: February 2024

In what concerns the Romanian constitutionalism following the First World War, the drafts of the Constitution (D. Ioanițescu, Romul Boilă, Constantin Berariu, and C. Stere) reflect four differ ent approaches. They tried to innovate in accordance with the assumed political ideology, while mostly keeping the structure and broad principles of the Constitution of 1866. In the proposal made by Constantin Stere, one can see, for instance, the concepts of administrative decentraliza tion and regionalization as well as the idea of a unicameral parliament. Likewise, the Liberal pro posal is the only one that did not respect the structure of the 1866 Constitution and placed the issue of state powers before that of citizens’ rights. Another idea that can be highlighted emerges from the ideas of Romul Boilă, who does not state the unitary character of the Romanian state, considering that this fact “should not be declared, but it must exist.” Yet, due to the political changes that were occurring at the time in Romania, the Liberal vision prevailed.
The 1923 Constitution, a Source for Romania’s Administrative Reorganizations Until the Establishment of the Communist Regime: Case Study: Bihor County
Authors:   Faculty of History, International Relations, Political Sciences and Communication Sciences, University of Oradea., Moisa Gabriel , Moisa Ștefan
Published: February 2024

The present study attempts to highlight the originality of the Romanian Enlightenment in Transylvania, looking at the way in which the pre-Enlightenment ideas belonging to Dimitrie Cantemir, grounded in the ideological structure of pre-Romanticism in Central Europe, ger minated into the discourse of the members of the Transylvanian School. On the one hand, the author of the study investigates, for each member of the Transylvanian School (Gherontie Cotore, Samuil Micu, Gheorghe Șincai, Petru Maior, Ioan Budai-Deleanu), the takeovers from Cantemir’s work, and, on the other hand, their civic, militant, pragmatic interpretation appropri ate to the political priorities in Transylvania.
Iuliu Maniu and the Memorandum Movement
Authors:   Romanian Academy, Pușcaș Vasile
Published: February 2024

The Memorandum Movement (1892–1894) played an important role in the history of the na tional emancipation of the Transylvanian Romanians. Iuliu Maniu (1873–1953) studied law at the universities of Budapest and Vienna at the beginning of the last decade of the 19th century. In 1892 he was among the leaders of the Petru Maior Academic Society, an organization of Roma nian students at the University of Budapest. As a result of his position as the Romanian students’ leader, he had a major role in preparing the reception and accommodation of Memorandum delegates in Vienna. Iuliu Maniu and his colleagues immediately joined the Romanian national movement. He was among the signatories of the political Manifesto entitled “To the Romanian People of Transylvania and the Hungarian Land” (1893). In 1896, Iuliu Maniu was already one of leaders of the Romanian National Party from Transylvania.
Incursión en la memoria de los lugares inmortalizados por artistas gráficos, reporteros bélicos en la guerra ruso-rumano-turca de 1877-1878
Authors:   Faculty of Geography, Babeș-Bolyai University, Cluj-Napoca, Păcurar Alexandru , Tofan George-Bogdan ,   Faculty of Economics, Computer Scienceand Engineering, Vasile Goldiș West University, Arad
Published: February 2024

At the beginning of the 19th century, in a context in which Eastern Europe drew most of the media’s attention, the means of communication provided the public opinion with images and news from this region. The Russian-Romanian-Turkish War (1877–1878), also known as Romania’s Indepen dence War, sparked a lot of interest abroad, due to the considerable number of military observers and artists sent as war correspondents and accredited by the belligerent parties. We will make ex tensive reference to a work comprising a set of informative articles whose documentary value is enhanced by engravings which cover a wide array of topics. It is a collective volume with contri butions from war correspondents and artists-illustrators, some attracted by the landscape and the urban environment (Ladislaus Eugen Petrovits, Themistocles von Eckenbrecher), others by the combatants’ faces and appearance (Auguste Lançon), others by the uniforms, military equip ment and war scenes (Dick de Lonlay, Johann Nepomuk Schönberg), or by the inhabitants’ way of life and activity (José Luis Pellicer). We can also mention the following illustrators who depic ted scenes from the Russian-Romanian-Turkish war: Mathes Koenen, Emil Volkers and Friedrich Kaiser. There are also superb images capturing crucial moments of the conflict, whose author is the engraver Carol Popp de Szathmári (Károly Szathmári Pap). Our approach is an interdisciplinary one, given that it contains elements of geography, history, anthropology, sociology, geopolitics, economy and art, which turns it into an analysis of cordial geography, calligeography or beautiful geography
Romania’s Foreign Policy in the Middle East during the Cold War: The Communist Leadership’s Quest for Legitimacy and the Origin of Nicolae Ceaușescu’s Wish to Win the Nobel Peace Prize
Authors:   Faculty of History, University of Bucharest, Dobre Mihail
Published: February 2024

There are times when small nations can make “great history,” and after 1964 Romania made
such a history for a decade or so. The communist government in Bucharest—and to a far lesser
extent the Romanian people—benefited from the international perception that its foreign policy
was able to generate in the specific environment of the Cold War. The honors with which Nicolae
Ceaușescu was received everywhere in the civilized world were the most visible expression of
this state of affairs. A key dimension of the Romanian foreign policy was its focus on the crisis
in the Middle East. The Bucharest leadership was widely praised for intermediating the contacts
between Israel and Egypt, which ultimately led to the signing of the 1978 Camp David Accords.
The reasons behind this foreign policy of the Bucharest regime are investigated in-depth, as
the Romanian leaders themselves surprisingly stated that they were not mediators in that crisis,
while investing a great deal of energy and resources in finding a solution to it. One interesting
explanation arose from the archives of the Romanian Ministry of Foreign Affairs, which ascribes
Ceaușescu’s efforts in the Middle East to the elusive dream of gaining the international recogni tion brought by the Nobel Peace Prize.
On Russian Aggressiveness
Authors:   Faculty of History and Philosophy, Babeș-Bolyai University, Cluj-Napoca, Cipăianu George
Published: February 2024

An analysis of Russian aggressiveness trough the centuries. The essence of Russian aggressiveness
in international relations is commented on the basis of historical evidence.
Time in Dimitrie Cantemir’s
Sacro-sanctae Scientiae
Indepingibilis Imago (1700)
Authors:   Faculty of Foreign
Languages and Literatures, University
of Bucharest, Alexandrescu Vlad
Published: February 2024

Educated in Constantinople in the last decades of the 17th century, Dimitrie Cantemir (1673–
1723) encountered, on the one hand, the Paduan Aristotelianism transmitted by the Greek philo sophical teachers trained in Venice and Padua, and, on the other, was inspired by a Platonic,
Neoplatonic and Pseudo-Dionysian tradition, still alive in Eastern Christian thought. Written
after a thorough study of the work of J. B. van Helmont, his treatise on time echoes these mul tiple roots and proposes a conception of time which affirms the non-categoriality and neutrality of
the notion of time, its continuous, uniform, immovable, non-successive, immiscible, immutable
character, distributive in the singular time of each creature (according to the model of Platonic
participation), its participation in eternity, the emanation of eternity from the divine Intellect, and
the precedence of time over Creation
Blood Revenge in Montenegro and the Code of Danilo, Prince of Montenegro (1851–1860)
Authors:   Faculty of Philosophy, University of Montenegro, Doderović Miroslav , Aleksić Budimir ,   Faculty of Culture and Media, Megatrend University
Published: February 2024

The opinion that blood revenge was definitively eradicated in Montenegro during Danilo’s time ran into very serious difficulties and could not be maintained. Its serious traces, although not in the classic form, are encountered not only in the 19th but also in the 20th century. By 1870, Danilo’s code was in full force, and since then 40 of its “articles” have remained in force.
Aesthetic Considerations on György Ligeti’s Works
Authors: Cojocaru Dora
Published: February 2024

This article represents a revised chapter of my book György Ligeti’s Creation in the Stylistic Context of the 20st Century, published in 1999. It shows the divergent and contrasting aspects of the com poser’s pieces, their synaesthesis and their preference for allusions and illusions. Ligeti’s whole work is a large spectrum built with associable musical structures that are also found with other composers or even in extramusical artistic productions. But despite this, it remains original and innovative, not belonging to any stylistic orientation of 20th century music.
ANALISIS SISTEM INFORMASI MANAJEMEN RUMAH SAKIT UMUM TEUNGKU PEUKAN DI ACEH DITINJAU DARI PERENCANAAN
Authors: Agustina Rini Fitri , Zaman Nasrul , Nurjannah Nurjannah , Saputra Irwan , Usman Said
Published: February 2024

Sistem Informasi Manajemen Rumah Sakit (SIMRS) merupakan sebuah sistem terpadu yang mengatur pengumpulan berbagai data, selanjutnya data tersebut diolah menjadi informasi yang dibutuhkan oleh pemangku kepentingan di rumah sakit. SIMRS disiapkan untuk menangani seluruh proses manajemen rumah sakit, untuk itu diperlukan proses perencanaan komponen sistem informasi (KSI) agar efektif dan menghasilkan data yang akurat, relevan, dan konsisten secara tepat waktu. Penelitian ini bertujuan untuk mengetahui optimalisasi SIMRS dan menganalisis perencanaan sistem informasi (KSI) meliputi perencanaan infrastruktur, perangkat keras dan lunak, brainware dan teknologi di Rumah Sakit Umum Teungku Peukan (RSUTP). Penelitian ini adalah penelitian kualitatif. Analisis data menggunakan pendekatan tematik. Subjek penelitian adalah manajer level atas, menengah dan bawah serta tenaga teknologi informasi yang mengelola SIMRS di RSUTP berjumlah sepuluh orang. Hasil penelitian menunjukkan bahwa perencanaan KSI di RSUTP antara lain dengan pembuatan masterplan bangunan rumah sakit tanpa disertai site plan jaringan internet dan listrik untuk SIMRS; perencanaan pengadaan komputer tidak dengan UPS; perencanaan perangkat lunak SIMRS disesuaikan dengan kebutuhan pengguna; kerangka acuan kerja untuk pelatihan belum ada; tidak semua tim manajemen dilibatkan dalam perencanaan teknologi. Dapat disimpulkan bahwa perencanaan komponen sistem informasi di Rumah Sakit Umum Teungku Peukan belum optimal dan menyeluruh.
IMPACT OF DIFFERENT NPK LEVELS AND SOWING METHODS ON MAIZE GROWTH, YIELD, AND QUALITY CHARACTERISTICS
Authors: Laghari Aziz , Buriro Mahmooda , Laghari Ghulam Mustafa , Talpur Khalid Hussain
Published: February 2024

Crop management practices are crucially important to increased yield and quality. This research study was planned to investigate the effects of different levels of NPK and sowing methods on maize. Results showed that different NPK levels and sowing methods significantly affected the growth and yield traits of maize (p<0.05). The better results for plant height (cm), leaf area index, cob length (cm), grains per cob, 1000-grain weight, grain yield (kg ha-1), protein content (%) total sugars (%) and starch (%) were recorded when crop-fertilized NPK with 150-120-120 kg ha-1. However, all these parameters were marginally different compared to NPK rate of 120-90-90 kg ha-1, except for plant height (cm). This treatment produced significantly higher grain yield and quality traits of maize compared to lower and control treatment. Minimum values for plant height (cm), leaf area index, cob length (cm), grains per cob, 1000-grain weight, grain yield kg ha-1, protein content (%), total sugars (%) and starch (%) were noted in the control treatment. In case of sowing methods, ridge sowing produced maximum plant height (cm) , leaf area index, 50% days to tasselling and yield contributing characters like cob length (cm), grains cob-1, 1000-grain weight (g) and grain yield (kg ha-1) of maize as compared to broadcasting and drilling sowing methods. But sowing methods did not significantly affected the quality characteristics of maize, particularly protein content (%), total sugars (%) and starch (%). Among different sowing methods,  ridge sowing method produced the maximum grain yield kg ha-1 of maize as compared to drilling and broadcasting. Considering the results comprehensively, the NPK rate of 120-90-90 kg ha-1 under ridge method would be the best management practice for maize cultivation:
INFLUENCE OF DIFFERENT HOUSING SYSTEMS ON THE QUALITY CHARACTERISTICS OF TABLE EGG PRODUCED BY PLAYMOUTH ROCK CHICKEN
Authors: Kaleri Rameez , Kaleri Hubdar Ali , Moryani , Ahmed Ali , Mangrio Zahid Ali , Bhuptani Deepesh Kumar , Janyaro Habibullah , Khoso Zafar Ali , Ahmed Imran , Khusk Farooque Ahmed , Ishaq Samra , Laghari Sajjad Ali , Jamali Zuhaib , Arif Muhammad
Published: February 2024

The present experiment was conducted to observe the quality of table eggs collected from three different housing systems, including conventional cage systems, floor space-free ranges, and limited floor space systems, at Mr. Janazaib Arain farm in Nasarpur, Sindh. In this experiment, the Playmouth chicken breed was kept under the housing system. It was observed that the various table egg quality characteristics-egg weight, eggshell cleanness, eggshell hardness, breaking strength, shape index, egg yolk color, and egg albumin height were significantly higher (P<0.05) in the cage system as compared with free range, limited, and free floor space. The result for egg mass was also found to be significantly higher in the cage housing system as compared with other housing systems. It was concluded that a better-quality table egg with a higher egg weight, a hard eggshell, and other internal quality characteristics can be produced in the cage housing system from Playmuoth Rock chickens.
Investigation of the ability of final-year medical students to deliver bad news
Authors: Paknezhad Seyedpouya , Vand Rajabpour Zahra
Published: February 2024

Introduction: Delivering bad news (DBN) is an essential communication for all doctors. There are many benefits of DBN, for both the patient and the healthcare team looking after the patient. Having a general perspective of the ability of medical students in DBN can help us to improve educational programs in the future; therefore, the purpose of this study was to investigate the ability of final-year medical students to DBN. Methods: 150 final-year medical students, who were undergoing their internship in different clinical courses, participated in this study. The translated questionnaire of SPIKES guidelines was used to measure the skill of senior medical students in DBN to patients, which includes 16 questions. Student t-test was used to compare quantitative variables and a chi-square test was used to compare qualitative variables. Results: The mean age of participants was 26.19±.94 years with a minimum age of 26 years with a median of 29 years. (36%0) males and 96(64%) females formed the study population. the total score and the environmental score of DBN are significantly higher in female students. Also, according to the Pearson test, no significant correlation was observed between the age of the final year and the fields of ability in DBN (P=0.512, r=0.021). Conclusion: Due to the lack of sufficient training on how to communicate with patients and deliver bad news, adding a training program to increase the skills of medical students in DBN to the general medical training curriculum can be useful in improving the academic aspects of general practitioners.
Predicting outcomes in trauma patients by using reverse shock index multiplied by Glasgow coma scores (rSIG): A retrospective cross-sectional study
Authors: Paknezhad Seyed Pouya , Vand Rajabpour Zahra , Morteza Bagi Hamid Reza , Shahryari Ghalehlar Reza , Pourtagi Anvarian Samira
Published: February 2024

Introduction: This study aimed to determine the predictive value of the reverse shock index (rSI) using the Glasgow Coma Score (GCS) to predict the outcome of traumatic patients. Methods: This study included all patients with a traumatic injury aged≥18 years with ISS score≥16 and head Abbreviated Injury Scale (AIS)≥2 admitted to the Imam Reza hospital of Tabriz, Iran from 1 March, 2021 to 1 July, 2021. After excluding the patients with incomplete data, 216 patients were enrolled. In this study, the rSIG is the product of rSI multiplied by the GCS score. The patients’ symptoms were recorded routinely in the summary section of all patients’ records using the studied indexes. Data collection was performed using the researcher-made forms. The SPSS software v.21 was used to analyze the data. A P-value<0.05 was considered as statistically significant. Results: The results of data analysis demonstrated that the regression model by two predicting variables of rSI and rSIG was statistically significant. Also, the model can distinguish between the patients who died and those who were discharged. In addition, the Hosmer-Lemeshow test confirmed the model’s advantage and its accuracy (χ2=14.12, df=8, P>0.05). Conclusion: So, the predictive value of rSI with GCS in predicting the outcome of traumatic patients was high.
Interaction of biotin and oxybiotin with magnesium dication. A DFT treatment
Authors: Türker Lemi
Published: February 2024

The present computational study, considers the perturbational effect of magnesium cation on two biologically important molecules, biotin and oxybiotin within the restrictions of density functional theory at the level of B3LYP/6-31++G(d,p). The results reveal that both of the composite molecules have exothermic heat of formations and favorable Gibbs free energy of formation values at the standard state. They are electronically stable. Various quantum chemical data accompanying the considered perturbation have been collected and discussed including UV-VIS spectra. Both the HOMO and LUMO energies of oxybiotin+Mg+2 composite have been lowered down at unequal extents as compared to the biotin+Mg+2 composite in such a way that interfrontier molecular orbital energy gap value of it is much greater than the respective value of biotin+Mg+.
Responsabilidad profesional y su regulación en el contexto legal peruano: Divergencias y perspectivas
Authors: Romero-Graus Carlos Hernán , Vargas-Flores Rosa Luz
Published: February 2024

El objetivo general de la investigación fue analizar la responsabilidad profesional y su regulación en el contexto legal peruano: Divergencias y Perspectivas. El método empleado en la investigación, se basó en el enfoque cualitativo, manejando la recolección y análisis de una tipología documental-bibliográfica. La técnica aplicada fue la entrevista; la herramienta o instrumento fue la guía de entrevista; la cual se aplicó a magistrados del Distrito Judicial de La Libertad, docentes de las Universidades de Trujillo y abogados especializados en derecho civil. Generándose un proceso analítico–reflexivo. La recopilación de datos se realizó respetando los principios éticos. Se concluye que, la percepción de los entrevistados reveló una divergencia significativa. Mientras que un grupo considera que esta norma establece un régimen privilegiado de responsabilidad civil para los profesionales, otro grupo la interpreta de manera contraria; sin embargo, no se contradice con las teorías y doctrina jurídica.
Adolescentes infractores inmersos en las bandas criminales en el Ecuador
Authors: Crespo-Berti Luis Andrés
Published: February 2024

El objetivo general del presente estudio fue analizar a los adolescentes infractores inmersos en las bandas criminales en el Ecuador. El método empleado en la investigación, se basó en el enfoque cualitativo, manejando la recolección y análisis de una tipología documental-bibliográfica, contribuyendo al análisis del objeto de estudio. La técnica de investigación aplicada fue la entrevista; la herramienta o instrumento en que se apoyó fue la guía de entrevista. Generándose un proceso analítico–reflexivo. Se concluyó que el incremento de la violencia y la inseguridad, generado por las bandas criminales asociadas a los adolescentes, crean un estado de inestabilidad e incertidumbre, así como un abocamiento laxo por parte de las autoridades que dan como resultado un estado de extrema violencia.
Efectos de la imposición automática de la pena de inhabilitación definitiva
Authors: Mendoza-Tejada Evelyn Denisse
Published: February 2024

El objetivo general de la investigación fue analizar jurídicamente los efectos de la imposición automática de la pena de inhabilitación definitiva. Se desarrolló desde la perspectiva cuantitativa, mediante la búsqueda, recolección y análisis crítico documental, referencial bibliográfico, desde un diseño bibliográfico de tipo documental, el investigador realizó un proceso investigativo en donde la población de estudio, se fundamentó básicamente en documentos escritos como trabajos arbitrados, revistas científicas, tesis, entre otros, se consideró el análisis de contenido de la información recopilada. Se planteó además el método analítico-sintético. Se concluye que, después de analizar los resultados de la investigación se puede concluir que la afectación que produce la pena de inhabilitación en el principio de igualdad en el Distrito Judicial de Amazonas, al 2023 ocurre no solo porque se trata de un derecho fundamental constitucionalmente protegido, si no por cuanto no debe existir desproporcionalidad en la aplicación de las penas.
El gobierno electrónico en la labor fiscal del Ministerio Público, Perú
Authors: Llasacce-Orosco Uriel
Published: February 2024

El objetivo general de la investigación fue analizar el gobierno electrónico en la labor fiscal del Ministerio Público, Perú. La investigación se desarrolló desde el paradigma positivista y desde la perspectiva cuantitativa, mediante la búsqueda, recolección y análisis crítico documental, referencial bibliográfico y estudios de investigación. En este sentido, desde un diseño bibliográfico de tipo documental, los investigadores realizaron un proceso investigativo en donde la población de estudio, se fundamentó básicamente en documentos escritos como trabajos arbitrados, revistas científicas, tesis, entre otros. Se plantea además el método analítico-sintético. Se concluye que, los instrumentos que proporciona el gobierno electrónico como el uso de las Tecnologías de la Información y Comunicación (TIC) optimiza el trámite y actuación de la administración pública, dotándola en eficaz y eficiente; razón por la cual debe ser implementado en el sector justicia, especialmente en el Ministerio Público.
Tutela de los derechos del administrado y los procedimientos sancionadores en los gobiernos locales, Perú
Authors: Rodríguez-Diestra Franco Nerdy
Published: February 2024

El objetivo general de la investigación fue analizar la tutela de los derechos del administrado y los procedimientos sancionadores en los gobiernos locales, Perú. El método desarrollado por el investigador se basó en el enfoque cualitativo, y se utilizaron fuentes bibliográficas, a fin de conseguir información real y actualizada para poder alcanzar el objetivo planteado, frente al problema jurídico en análisis. Apoyado en las técnicas analítica–sintética, además del método inductivo. Se empleó el fichaje y la entrevista. Los informantes clave: Dos (2) abogados especialistas en materia de derecho administrativo, dedicados a la defensa; siete (7) servidores públicos, gerentes, subgerentes y jefes, que participaron como órgano instructor, sancionador o ejecutor en los gobiernos locales de Trujillo; un (1) catedrático. Se concluyó que, los derechos del administrado en la aplicación de procedimientos sancionadores en los gobiernos locales no se tutelan de manera adecuada.
Derechos Humanos y Migración
Authors: Giménez-Guariguata Maribel José
Published: February 2024

Editorial
Materias tangibles en mediación de litigios familiares bajo el interés superior del niño, Ecuador
Authors: Gil-Osuna Bartolomé , Lizcano-Chapeta Carlos Javier
Published: February 2024

El objetivo general fue analizar jurídicamente las materias tangibles en mediación de litigios familiares bajo la mirada del interés superior del niño, Ecuador. La investigación se desarrolló desde el paradigma positivista y desde la perspectiva cuantitativa, mediante la búsqueda, recolección y análisis crítico documental, referencial bibliográfico y estudios de investigación, en este sentido, desde un diseño bibliográfico de tipo documental, el investigador realizó un proceso investigativo en donde la población de estudio, se fundamentó básicamente en documentos escritos como trabajos arbitrados, revistas científicas, tesis, entre otros. Se planteó además el método analítico-sintético. Se concluye que, el ámbito de aplicabilidad de la mediación es bastante amplio, debido a que no existe un cuadro preestablecido que defina, en el campo jurídico, en qué tipos de conflictos se debe o no recurrir a la misma, solo se menciona el hecho de ser transigible o no.