bluuebunny/crossref_metadata_2025 huggingface dataset:
Tyramine Derivatives as Potent Therapeutics for Type 2 Diabetes: Synthesis and In Vitro Inhibition of α-Glucosidase Enzyme
Authors: Bashir Muhammad A. , Javaid Kulsoom , Shaikh Muniza , Choudhary Muhammad I. , Siddiqui Hina
Published: January 2020

Background:

Tyramine derivatives 3-16 were prepared and tested first time for their α-
glucosidase (Sources: Saccharomyces cerevisiae) inhibitory activity by using an in vitro mechanismbased
biochemical assay. All the compounds were found to be new, except compounds 3, 10-12 and
16.

Objective:

In continuation of our research to synthesize and identify potent inhibitors of α-glucosidase
enzyme, we intended to synthesize new inhibitors of α-glucosidase enzyme with enhanced efficacy in
order to provide the basis for the better treatment of the type-II diabetic.

Methods:

Tyramine (1) was allowed to react with a variety of aryl chlorides (2) to yield the corresponding
amides. Synthesized compounds were then purified through normal phase column chromatography.
Compounds 3-16 were then assessed for their α-glucosidase inhibitory activity in an in
vitro biochemical assay. The cytotoxicity of compounds 3-16 was determined by using 3T3 mouse
fibroblast cell lines.

Results:

Compounds 3-5, 8, 13, and 15-16 were found to be more active (IC50 = 103.1±0.46,
37.3±4.51, 56.7±4.2, 23.9±2.31, 43.6±2.88, 55.8±1.73, and 38.2±0.86 μM, respectively) than the
acarbose, the standard inhibitor of α-glucosidase enzyme, (IC50= 840.0±1.73 μM). To determine the
dissociation constants and mode of inhibition, the kinetic studies were also performed for compounds
4 and 8 (the most potent inhibitors). It was observed that compounds 4 and 8 possess noncompetitive
properties as the inhibitors of α-glucosidase. All the compounds were found to be noncytotoxic,
except 5 and 12 (IC50= 14.7± 0.24 and 6.6± 0.38 μM, respectively).

Conclusion:

The current study gives the facile synthesis and identification of potent inhibitors of α-
glucosidase. The new inhibitors reported here may be investigated further for the designing and
development of novel anti-diabetic agents.
Synthesis, In vitro, and Docking Analysis of C-3 Substituted Coumarin Analogues as Anticancer Agents
Authors: Thakur Anuradha , Kaur Kamalpreet , Sharma Praveen , Singla Ramit , Singh Sandeep , Jaitak Vikas
Published: January 2020

Background:

Breast cancer (BC) is a leading cause of cancer-related deaths in women next to skin cancer. Estrogen receptors (ERs) play an important role in the progression of BC. Current anticancer agents have several drawbacks such as serious side effects and the emergence of resistance to chemotherapeutic drugs. As coumarins possess minimum side effect along with multi-drug reversal activity, it has a tremendous ability to regulate a diverse range of cellular pathways that can be explored for selective anticancer activity.

Objectives:

Synthesis and evaluation of new coumarin analogues for anti-proliferative activity on human breast cancer cell line MCF-7 along with exploration of binding interaction of the compounds for ER-α target protein by molecular docking.

Method:

In this study, the anti-proliferative activity of C-3 substituted coumarins analogues (1-17) has been evaluated against estrogen receptor-positive MCF-7 breast cancer cell lines. Molecular interactions and ADME study of the compounds were analyzed by using Schrodinger software.

Results:

Among the synthesized analogues 12 and 13 show good antiproliferative activity with IC50 values 1and 1.3 µM respectively. Molecular docking suggests a remarkable binding pose of all the seventeen compounds. Compounds 12 and 13 were found to exhibit dock score of -4.10 kcal/mol and -4.38 kcal/mol respectively.

Conclusion:

Compounds 12 and 13 showed the highest activity followed by 1 and 5. ADME properties of all compounds were in the acceptable range. The active compounds can be taken for lead optimization and mechanistic interventions for their in vivo study in the future.
Cancer Fighting SiRNA-RRM2 Loaded Nanorobots
Authors: Sharma Arjun , Kumar Pravir , Ambasta Rashmi K.
Published: January 2020

Background:

Silencing of several genes is critical for cancer therapy. These
genes may be apoptotic gene, cell proliferation gene, DNA synthesis gene, etc. The two
subunits of Ribonucleotide Reductase (RR), RRM1 and RRM2, are critical for DNA synthesis.
Hence, targeting the blockage of DNA synthesis at tumor site can be a smart mode
of cancer therapy. Specific targeting of blockage of RRM2 is done effectively by SiRNA.
The drawbacks of siRNA delivery in the body include the poor uptake by all kinds of cells,
questionable stability under physiological condition, non-target effect and ability to trigger
the immune response. These obstacles may be overcome by target delivery of siRNA at the
tumor site. This review presents a holistic overview regarding the role of RRM2 in controlling
cancer progression. The nanoparticles are more effective due to specific characteristics
like cell membrane penetration capacity, less toxicity, etc. RRM2 have been found to be
elevated in different types of cancer and identified as the prognostic and predictive marker
of the disease. Reductase RRM1 and RRM2 regulate the protein and gene expression of
E2F, which is critical for protein expression and progression of cell cycle and cancer. The
knockdown of RRM2 leads to apoptosis via Bcl2 in cancer. Both Bcl2 and E2F are critical
in the progression of cancer, hence a gene that can affect both in regulating DNA replication
is essential for cancer therapy.

Aim:

The aim of the review is to identify the related gene whose silencing may inhibit cancer
progression.

Conclusion:

In this review, we illuminate the critical link between RRM-E2F, RRM-Bcl2,
RRM-HDAC for the therapy of cancer. Altogether, this review presents an overview of all
types of SiRNA targeted for cancer therapy with special emphasis on RRM2 for controlling
the tumor progression.
Facilitators and Barriers to Recruiting Ambulatory Oncology Practices Into a Large Multisite Study: Mixed Methods Study
Authors: Manojlovich Milisa , Bedard Louise , Griggs Jennifer J , McBratnie Michaella , Mendelsohn-Victor Kari , Friese Christopher R
Published: January 2020

Background

Practice-based research is essential to generate the data necessary to understand outcomes in ambulatory oncology care. Although there is an increased interest in studying ambulatory oncology care, given the rising patient volumes and complexity in those settings, little guidance is available on how best to recruit ambulatory oncology practices for research.

Objective

This paper aimed to describe the facilitators and barriers to recruiting ambulatory oncology practices into a large multisite study.

Methods

Using a mixed methods design, we sought to recruit 52 ambulatory oncology practices that have participated in a state-wide quality improvement collaborative for the quantitative phase. We used 4 domains of the Consolidated Framework for Implementation Research (CFIR) to describe facilitators and barriers to recruitment.

Results

We successfully recruited 28 of the 52 collaborative-affiliated practices, collecting survey data from 2223 patients and 297 clinicians. Intervention attributes included multimodal outreach and training activities to assure high fidelity to the data collection protocol. The implementation process was enhanced through interactive training and practice-assigned champions responsible for data collection. External context attributes that facilitated practice recruitment included partnership with a quality improvement collaborative and the inclusion of a staff member from the collaborative in our team. Key opinion leaders within each practice who could identify challenges to participation and propose flexible solutions represented internal context attributes. We also reported lessons learned during the recruitment process, which included navigating diverse approaches to human subjects protection policies and understanding that recruitment could be a negotiated process that took longer than anticipated, among others.

Conclusions

Our experience provides other researchers with challenges to anticipate and possible solutions for common issues. Using the CFIR as a guide, we identified numerous recruitment barriers and facilitators and devised strategies to enhance recruitment efforts. In conclusion, researchers and clinicians can partner effectively to design and implement research protocols that ultimately benefit patients who are increasingly seeking care in ambulatory practices.
An Automated Blood Pressure Display for Self-Measurement in Patients With Chronic Kidney Disease (iHealth Track): Device Validation Study
Authors: Mazoteras-Pardo Victoria , Becerro-De-Bengoa-Vallejo Ricardo , Losa-Iglesias Marta Elena , López-López Daniel , Calvo-Lobo César , Rodríguez-Sanz David , Martínez-Jiménez Eva María , Palomo-López Patricia
Published: January 2020

Background

Hypertension is a global public health issue and is closely related to chronic kidney disorder (CKD). In people with CKD, strict monitoring of blood pressure is an important part of therapy.

Objective

The aim of this research was to validate the iHealth Track blood pressure monitoring device for patients with CKD according to the European Society of Hypertension International Protocol 2010 (ESH-IP2).

Methods

In total, 33 patients who received hemodialysis in Plasencia participated in the study. There were 9 successive measurements made, which conformed to the ESH-IP2. We calculated the differences between the standard reference device (Omron M3 Intellisense) and the test device (iHealth Track) for blood pressure and heart rate values. For 99 total comparisons of paired measurements, we classified differences into various categories (≤5 mmHg, ≤10 mmHg, and ≤15 mmHg for blood pressure; ≤3, ≤5, and ≤8 beats per minute for heart rate).

Results

In 90 of 99 systolic blood pressure and 89 of 99 diastolic blood pressure comparisons between the devices, measurement differences were within 5 mmHg. In 81 of 99 heart rate comparisons between the devices, measurement differences were within 3 beats per minute. The mean differences between the test and reference standard measurements were 3.27 (SD 2.99) mmHg for systolic blood pressure, 3.59 (SD 4.55) mmHg for diastolic blood pressure, and 2.18 (SD 2.75) beats per minute for heart rate.
We also observed that for both systolic and diastolic blood pressure, 31 of 33 participants had at least two of three comparisons between the devices with measurement differences less than 5 mmHg. For heart rate, 28 of 33 patients had at least two of three comparisons between the devices with measurement differences less than 3 beats per minute.

Conclusions

To our knowledge, this is the first study to show that iHealth Track meets the requirements of the ESH-IP2 in patients with CKD. Therefore, the iHealth Track is suitable for use in renal patients.
Effect of Age on the Initiation of Biologic Agent Therapy in Patients With Inflammatory Bowel Disease: Korean Common Data Model Cohort Study
Authors: Choi Youn I , Kim Yoon Jae , Chung Jun-Won , Kim Kyoung Oh , Kim Hakki , Park Rae Woong , Park Dong Kyun
Published: January 2020

Background

The Observational Health Data Sciences and Informatics (OHDSI) network is an international collaboration established to apply open-source data analytics to a large network of health databases, including the Korean common data model (K-CDM) network.

Objective

The aim of this study is to analyze the effect that age at diagnosis has on the prognosis of inflammatory bowel disease (IBD) in Korea using a CDM network database.

Methods

We retrospectively analyzed the K-CDM network database from 2005 to 2015. We transformed the electronic medical record into the CDM version 5.0 used in OHDSI. A worsened IBD prognosis was defined as the initiation of therapy with biologic agents, including infliximab and adalimumab. To evaluate the effect that age at diagnosis had on the prognosis of IBD, we divided the patients into an early-onset (EO) IBD group (age at diagnosis <40 years) and a late-onset (LO) IBD group (age at diagnosis ≥40 years) with the cutoff value of age at diagnosis as 40 years, which was calculated using the Youden index method. We then used the logrank test and Cox proportional hazards model to analyze the effect that age at diagnosis (EO group vs LO group) had on the prognosis in patients with IBD.

Results

A total of 3480 patients were enrolled. There was 2017 patients with ulcerative colitis (UC) and 1463 with Crohn’s disease (CD). The median follow up period was 109.5 weeks. The EO UC group was statistically significant and showed less event-free survival (ie, experiences of biologic agents) than the LO UC group (P<.001). In CD, the EO CD group showed less event-free survival (ie, experiences of biologic agents) than the LO CD group. In the Cox proportional hazard analysis, the odds ratio (OR) of the EO UC group on experiences of biologic agents compared with the LO UC group was 2.3 (95% CI 1.3-3.8, P=.002). The OR of the EO CD group on experiences of biologic agents compared with the LO CD group was 5.4 (95% CI 1.9-14.9, P=.001).

Conclusions

The EO IBD group showed a worse prognosis than the LO IBD group in Korean patients with IBD. In addition, this study successfully verified the CDM model in gastrointestinal research.
Use of Mental Health Apps by Patients With Breast Cancer in the United States: Pilot Pre-Post Study
Authors: Chow Philip I , Showalter Shayna L , Gerber Matthew , Kennedy Erin M , Brenin David , Mohr David C , Lattie Emily G , Gupta Alisha , Ocker Gabrielle , Cohn Wendy F
Published: January 2020

Background

Nearly half of the patients with breast cancer experience clinically significant mental distress within the first year of receiving their cancer diagnosis. There is an urgent need to identify scalable and cost-efficient ways of delivering empirically supported mental health interventions to patients with breast cancer.

Objective

The aim of this study was to evaluate the feasibility of in-clinic recruitment for a mobile phone app study and to evaluate the usability and preliminary impact of a suite of mental health apps (IntelliCare) with phone coaching on psychosocial distress symptoms in patients recently diagnosed with breast cancer.

Methods

This pilot study adopted a within-subject, 7-week pre-post study design. A total of 40 patients with breast cancer were recruited at a US National Cancer Institute–designated clinical cancer center. Self-reported distress (Patient Health Questionnaire-4) and mood symptoms (Patient-Reported Outcomes Measurement Information System depression and anxiety scales) were assessed at baseline and postintervention. App usability was assessed at postintervention.

Results

The minimum recruitment threshold was met. There was a significant decrease in general distress symptoms, as well as symptoms of depression and anxiety, from baseline to postintervention. Overall, participants reported high levels of ease of app use and learning. Scores for app usefulness and satisfaction were reinforced by some qualitative feedback suggesting that tailoring the apps more for patients with breast cancer could enhance engagement.

Conclusions

There is a dire need for scalable, supportive interventions in cancer. The results from this study inform how scalable mobile phone–delivered programs with additional phone support can be used to support patients with breast cancer.

International Registered Report Identifier (IRRID)

RR2-10.2196/11452
A Mobile Sexual Health App on Empowerment, Education, and Prevention for Young Adult Men (MyPEEPS Mobile): Acceptability and Usability Evaluation (Preprint)
Authors: Gannon Brittany , Davis Rindcy , Kuhns Lisa M , Rodriguez Rafael Garibay , Garofalo Robert , Schnall Rebecca
Published: January 2020

BACKGROUND

HIV incidence among young adult men who have sex with men (MSM), particularly among black and Latino men, continues to rise. As such, continued HIV prevention interventions for young MSM of color are of utmost importance. Male Youth Pursuing Empowerment, Education and Prevention around Sexuality (MyPEEPS) Mobile is a comprehensive HIV prevention and sexual health education smartphone app initially created to promote sexual health and HIV prevention among adolescent sexual minority young men aged 13 to 18 years.

OBJECTIVE

The objective of this study was to critically appraise the acceptability and usability of MyPEEPS Mobile for young adult MSM aged 19 to 25 years.

METHODS

Study participants used the mobile app, completed usability questionnaires and in-depth interviews, and reported their experience using the app. Analysis of interview data was guided by the Unified Theory of Acceptance and Use of Technology (UTAUT) to better understand the usability and acceptability of this intervention for young adults. Interview data were coded using the following constructs from the UTAUT model: performance expectancy, effort expectancy, and social influence.

RESULTS

A total of 20 young adult MSM (n=10 in Chicago, Illinois, and n=10 in New York, New York) were enrolled in the study. Participants reported that MyPEEPS Mobile was free of functional problems (Health Information Technology Usability Evaluation Scale scores and Post-Study System Usability Questionnaire scores consistent with high usability), easy to use, and useful, with an engaging approach that increased acceptability, including the use of avatars and animation, and inclusive representation of the diverse identities by race and ethnicity, gender identity, and sexual orientation. Recommended areas for improving MyPEEPS Mobile for the target demographic included more adult-oriented graphics, advanced educational content, scenarios for youth with more sexual experience, and search function to increase accessibility of key content.

CONCLUSIONS

Overall, young adult MSM aged 19 to 25 years described the MyPEEPS Mobile as educational, informative, and usable for their sexual health education and HIV prevention needs, and they provided actionable recommendations to optimize its use and applicability for this age group.
A Rest Quality Metric Using a Cluster-Based Analysis of Accelerometer Data and Correlation With Digital Medicine Ingestion Data: Algorithm Development (Preprint)
Authors: Heidary Zahra , Cochran Jeffrey M , Peters-Strickland Timothy , Knights Jonathan
Published: January 2020

BACKGROUND

Adherence to medication regimens and patient rest are two important factors in the well-being of patients with serious mental illness. Both of these behaviors are traditionally difficult to record objectively in unsupervised populations.

OBJECTIVE

A digital medicine system that provides objective time-stamped medication ingestion records was used by patients with serious mental illness. Accelerometer data from the digital medicine system was used to assess rest quality and thus allow for investigation into correlations between rest and medication ingestion.

METHODS

Longest daily rest periods were identified and then evaluated using a k-means clustering algorithm and distance metric to quantify the relative quality of patient rest during these periods. This accelerometer-derived quality-of-rest metric, along with other accepted metrics of rest quality, such as duration and start time of the longest rest periods, was compared to the objective medication ingestion records. Overall medication adherence classification based on rest features was not performed due to a lack of patients with poor adherence in the sample population.

RESULTS

Explorations of the relationship between these rest metrics and ingestion did seem to indicate that patients with poor adherence experienced relatively low quality of rest; however, patients with better adherence did not necessarily exhibit consistent rest quality. This sample did not contain sufficient patients with poor adherence to draw more robust correlations between rest quality and ingestion behavior. The correlation of temporal outliers in these rest metrics with daily outliers in ingestion time was also explored.

CONCLUSIONS

This result demonstrates the ability of digital medicine systems to quantify patient rest quality, providing a framework for further work to expand the participant population, compare these rest metrics to gold-standard sleep measurements, and correlate these digital medicine biomarkers with objective medication ingestion data.
Perhitungan Konstanta Dielektrik Lapisan Tipis Graphene Monolayer Si-Face Hasil Pengukuran Synchrotron dengan Metode Kramers-Kronig dan Newton-Raphson (Halaman 49 s.d. 53)
Authors: Yihaa Roodhiyah Lisa’ , Rusydi Andrivo , Santoso Iman
Published: January 2020

Telah dilakukan perhitungan konstanta dielektrik nanostruktur epitaxial graphene monolayer pada substrat Si-face SiC dari hasil pengukuran data reflektivitas dengan metode Kramers-Kronig dan Newton-Raphson. Data yang digunakan yaitu data reflektivitas pada rentang energi 0.5 – 30 eV dari pengukuran di Hasylab Synchroton. Metode Kramers-Kronigmenghasilkan beda fase δ dan dengan menggunakan persamaan Fresnel dan persamaan Snelliusdigunakan untuk mengekstraksi konstanta dielektrik. Permasalahan pencarian titik nol dalam persamaan Fresnel ketika mengekstraksi konstanta dielektrik dapat diselesaikan dengan metode numerik Newton-Raphson. Hasil yang diperoleh menunjukkan beberapa hal penting : 1) metode Kramers-Kronig dan numerik Newton-Raphson dapat digunakan untuk mengekstraksi konstanta dielektrik graphene monolayer Si-face, 2) adanya puncak absorbsi asimetri pada energi 4,6, 6,1 dan 8,4 eV ditinjau dari bagian imajiner konstanta dielektrik dan indeks bias, 3) puncak pada energi 6,1 dan 8,4 eV berasal dari resonansi exitonic akibat adanya interaksi elektron-elektron dan elektron-hole dan puncak pada energi 4,6 eV berasal transisi antar pita (interband) dari π band ke π* band yang dimiliki material graphene monolayer.
Analisa Pergeseran Magnetic Domain Wall pada Lapisan Tipis Free Layer Co/Pd terhadap Pengaruh Dimensi Sampel (Halaman 55 s.d. 58)
Authors: Salamah Umi , Suharyadi Edi
Published: January 2020

Telah dilakukan analisa pergeseran magnetic domain wall pada lapisan tipis free layer Co/Pd dengan menggunakan software Object Oriented Micromagnetic Framework (OOMMF) berdasarkan persamaan Landau-Lifshitz Gilbert (LLG). Analisa dilakukan pada ukuran 100x100 nm dengan memvariasikan ukuran ketebalan yaitu 1 nm, 3 nm, dan 5 nm. Dengan pemberian medan eksternal dari arah sumbu (+)z, magnet saturasi dicapai pada 31.290 Oe untuk ketebalan 1 nm, 30.940 Oe pada ketebalan 3 nm, dan 30.660 Oe pada ketebalan 5 nm. Selanjutnya dilakukan analisa dengan variasi ukuran pada ketebalan 5 nm yaitu 100x100 nm, 300x100 nm dan 500x100 nm.  Magnet saturasi pada ukuran 300x100 nm dicapai pada pemberian medan eksternal sebesar 30.970 Oe dan magnet saturasi pada ukuran 500x100 nm dicapai pada pemberian medan eksternal sebesar 31.040 Oe.
Optimasi Kinerja Primitive Root Diffuser (PRD) dengan Teknik Sisipan Resonator Jamak (Halaman 25 s.d. 29)
Authors: Ahmad Fahrudin , - Harjana , - Suparmi , Yahya Iwan
Published: January 2020

Telah  dilakukan kajian untuk meningkatkan kinerja primitive roots diffuser (PRD) dengan model standar berbentuk Skyline dengan jumlah elemen 5x8. Teknik modifikasi yang telah diterapkan adalah penyisipan rangkaian resonator seperempat panjang gelombang dengan kedalaman yang bersesuaian dengan masing-masing elemen PRD. Pengujian dilaksanakan dengan metode interrupted noise mengacu kepada prosedur standar ISO 3382 untuk mendapatkan nilai waktu dengung T30 dan T20. Adapun respon spasial dari PRD yang dikembangkan disimulasikan dengan perangkat lunak AFMG Reflex. Hasil pengujian menunjukkan bahwa penambahan rangkaian resonator jamak berhasil mengurangi nilai waktu dengung rerata sebesar 0,78 dan 1,83 sekon berturut-turut untuk T30 dan T20 pada bentang frekuensi rendah. Di samping itu pemakaian resonator memperbaiki respon spasial omnidireksional PRD.
Kinerja Spektrometer Fotoakustik Laser CO2 untuk Deteksi Gas Etilen (C2H4), Aseton (C3H6O), Amonia (NH3) pada Gas Hembus Perokok
Authors: Yoga Darmawan Mahardika , - Mitrayana , Joko Wasono Ali
Published: January 2020

Kinerja spektrometer fotoakustik (SFA) telah dilakukan optimasi dan diaplikasikan. Karakterisasi SFA laser CO2 meliputi pemayaran garis laser CO2 dan garis serapan, penentuan kurva resonansi dan faktor kualitas, pengukuran noise sehingga diperoleh untuk faktor kualitas sebesar (14,5 + 0,6), (14,8 + 0,7), dan (14,2 + 0,6) dan batas deteksi terendah untuk gas etilen, aseton, amonia pada garis 10P14, 10P20, 10R14 yaitu (57,1 + 0,4) ppb, (63,8 + 2,4) ppb, dan (81,1 + 0,6) ppb. Selanjutnya SFA digunakan untuk mengukur konsentrasi gas etilen, aseton, amonia pada gas hembus perokok. Hasil pengukuran diolah menggunakan analisis multikomponen dan diperoleh konsentrasi rata-rata gas etilen, aseton, amonia pada gas hembus perokok tertinggi sebesar 1,303 ppm, 0,924 ppm, dan 1,753 ppm. Pada kondisi sebelum merokok diperoleh konsentrasi rata-rata gas etilen, aseton, amonia sebesar 0,873 ppm, 0,286 ppm, dan 1,137 ppm dan pada kondisi satu jam setelah merokok, konsentrasi gas hembus perokok diperoleh konsentrasi rata-rata gas etilen, aseton, amonia sebesar 0,901 ppm, 0,305 ppm, dan 1,176 ppm. Berdasarkan penelitian yang telah dilakukan ditemukan pola yang cukup identik yang ditunjukkan untuk ketiga jenis gas yaitu setelah 60 menit relawan merokok maka konsentrasi akhir gas etilen, aseton dan amonia akan sama dengan konsentrasi awalnya sebelum relawan merokok.kata kunci: Spektrometer Fotoakustik Laser CO2; perokok; analisis multikomponen
EFEKTIVITAS PENEGAKAN HUKUM DI BIDANG KEKAYAAN INTELEKTUAL OLEH PENYIDIK PEGAWAI NEGERI SIPIL
Authors: Citrawan Harison , Rasyidi Achmad Fikri
Published: January 2020

Kajian ini mencoba menggambarkan efektivitas penegakan hukum oleh PPNS di bidang kekayaan intelektual (KI). Dengan menggunakan psychological type of the cognitive function, ditemukan bahwa: Pertama, secara internal PPNS KI  (KI) sudah menjalankan tugas dan fungsi PPNS KI, meskipun belum pada level ideal. Faktor-faktor internal yang memengaruhi hal tersebut yakni: (i) belum terdapat struktur PPNS KI di Kantor Wilayah Hukum dan HAM, dan (ii) penempatan PPNS ke dalam jabatan atau posisi tertentu yang tidak relevan dengan tugas dan wewenang PPNS. Kedua, secara eksternal berdasarkan tinjauan normatif, dipahami bahwa penegakan hukum KI dapat menempuh beberapa jalur. Adapun normativitas kewenangan PPNS yang tidak mencakup ranah mediasi penal justru menyebabkan kewenangan mereka menjadi sangat terbatas.
QUO VADIS NEGARA KESEJAHTERAAN: MENEGUHKAN IDEOLOGI WELFARE STATE NEGARA HUKUM KESEJAHTERAAN INDONESIA
Authors: ELVIANDRI E.
Published: January 2020

Peneguhan ideologi welfare state negara hukum kesejahteraan Indonesia bertujuan untuk mewujudkan kesejahteraan masyarakat. Karakteristik dari negara hukum kesejahteraan Indonesia; 1) sebagai antithesis konsep negara liberal dan individualis. 2) Kesejahteraan rakyat tanggung jawab negara. 3) Penguasaan negara atas bumi, air, ruang angkasa dan kekayaan alam, memberikan peran besar bagi negara untuk mensejahterakan masyarakat. 4) Konstitusi Indonesia bercorak konstitusi ekonomi. Indonesia bukanlah minimal state atau necessary evil, dan bahkan bukan pula sekadar enabling state yang tetap memuja individualisme. Indonesia cenderung pada model institutionalist welfare state versi rejim konservatif sehingga meneguhkan ideologi welfare state negara hukum kesejahteraan Indonesia menjadi niscaya dilakukan sebagai bentuk ketundukan kepada konstitusi.
Pendekatan Positivistik dalam Studi Hukum Adat
Authors: Simarmata Rikardo
Published: January 2020

AbstractAdat Positive Legal Science was initiated to simplify Western People (officer, legal enforcer, scholar) to understand adat or adat law. There are two important process to produce and to formulate substance of Adat Positive Legal Science. First, introduction of positivism legal approach creates perspective seeing adat law as jurisprudence because it has elements supporting adat law as system. This approach differenciates Adat Positive Legal Science from adat law study based on social approach. Adat law social approach does not imagine universal elements which represent reality of adat and adat law diversity because its own uniqueness. This different dissociate Adat Positive Legal Science from social studies as initial references. Second, introduction of positivism approach is action to apply western legal thoughts to explain adat law. The result is bias explanation regarding adat law. It is argued that positivism approach in Adat Positive Legal Science sets apart nature of adat law which following dynamics social relation. This paper doesn not only elaborate the birth of Adat Positive Legal Science history, but also how Adat Positive Legal Science does not able to response dynamic adat law by looking back to the existing concepts and definitions. IntisariIlmu Hukum Adat Positif pada awalnya digagas untuk keperluan memudahkan Orang Barat (pejabat, penegak hukum, ilmuan) untuk memahami adat atau hukum adat. Ada dua hal penting dari proses melahirkan dan merumuskan muatan Ilmu Hukum Adat Positif ini. Pertama, introduksi pendekatan positivisme menghasilkan pandangan yang melihat hukum adat sebagai jurisprudence dan karena itu memiliki unsur-unsur yang menjadi penopang hukum adat sebagai sistem. Pendekatan ini mengakibatkan Ilmu Hukum Adat Positif menjadi berbeda dari studi-studi hukum adat yang menggunakan pendekatan sosial. Kajian sosial hukum adat tidak membayangkan ada unsur-unsur universal yang bisa merepresentasikan adat atau hukum adat, yang dalam kenyataanya beragam karena memiliki keunikan-keunikan. Perbedaan ini sekaligus menjauhkan Ilmu Hukum Adat Positif dari studi-studi sosial, yang dijadikannya sebagai rujukan awal. Kedua, introduksi pendekatan positivisme sekaligus merupakan tindakan menerapkan pemikiran-pemikiran Hukum Barat (western legal thoughts) dalam menggambarkan hukum adat. Hasilnya, sebagian gambaran mengenai hukum adat yang dihasilkan dari pendekatan ini, bersifat bias. Tulisan ini berargumen bahwa pendekatan posivistik dalam Ilmu Hukum Adat Positif telah membuat disiplin ini menjauh dari sifat alamiah hukum adat yaitu yang terus berkembang mengikuti proses dinamik relasi-relasi sosial. Tulisan ini, selain memaparkan sejarah kelahiran Ilmu Hukum Adat Positif, juga memperlihatkan bagaimana Ilmu Hukum Adat Positif tidak mampu merespon dinamika pada hukum adat dengan cara melihat ulang istilah dan konsep-konsep yang digunakan beserta pengertiannya.
KAJIAN YURIDIS MEMORANDUM OF UNDERSTANDING DALAM PENYELENGGARAAN PERJANJIAN KERJASAMA DAERAH BERDASARKAN PP NO. 28 TAHUN 2018 TENTANG KERJASAMA DAERAH
Authors: Rusdiana Saida - , Widyaningtyas Rizky Septiana
Published: January 2020

Penelitian ini bertujuan untuk mengetahui dan mengkaji kedudukan Memorandum Of Understanding (MoU) dalam penyelenggaraan perjanjian kerjasama daerah berdasarkan Peraturan Pemerintah No. 28 Tahun 2018 Tentang Kerjasama Daerah serta pemahaman bagi pemangku kebijakan mengenai hakikat MoU dalam Perjanjian Kerjasama Daerah. Penelitian ini menggunakan metode penelitian yuridis empiris. Penelitian ini dilakukan dengan mengkaji data primer dan data sekunder yang kemudian dianalisis secara kualitatif untuk menjawab permasalahan yang diangkat. MoU wajib dibuat sebagai syarat untuk dapat membuat perjanjian kerjasama daerah berdasarkan amanat Pasal 6 ayat (1) Peraturan Pemerintah No. 28 Tahun 2018 Tentang Kerjasama Daerah dimana salah satu tahapan yang harus dilalui adalah penyusunan dan penandatanganan kesepakatan bersama. MoU memiliki fungsi kontrol dari Kepala Daerah terhadap penyelengaraan kerjasama daerah, mengingat hubungan hukum yang timbul dalam penyelenggaraan kerjasama daerah berdimensi publik yang didasarkan pada pertimbangan efisiensi dan efektivitas pelayanan publik serta saling menguntungkan para pihak.
NONPERFORMING LOANS AND FINANCIAL STABILITY – THE CASE OF SERBIA
Authors: Lukić Velimir , Popović Svetlana , Janković Irena
Published: January 2020

This paper investigates resilience and stability of the Serbian banking sector in the light of deteriorated quality of its credit portfolio since the last world economic crisis. Nonperforming loans became a burning issue across Eastern European region. We used a set of indicators to appraise the magnitude of nonperforming loans’ burden to the banking sector’s soundness. Indicators verify that the Serbian banking sector was robust and solvent throughout crisis. Nonperforming loans were concentrated in nonfinancial corporations’ sector, while households sector performed much better, which influenced remedy measures undertaken. We carried out a comparison with peer countries and reviewed nonperforming loans resolution strategy implemented in Serbia. Our finding is that measures taken helped noticeably in reducing stock of nonperforming loans, with a caveat that reduction might have been too fast and too large so that bounce back effect cannot be excluded. Overall, financial stability has been preserved despite serious threats and without government financial aid.
THE RELATION BETWEEN MULTINATIONAL COMPANIES AND THE REPUBLIC OF SERBIA: INCOME TAXATION CONTEXT
Authors: Vržina Stefan , Janković Nenad
Published: January 2020

Host countries, especially developing countries, often grant tax incentives in order to attract foreign capital of multinational companies (MNCs), expecting positive effects of foreign direct investments on their economic development. Also, there is an opinion dominant in the literature that MNCs have enough power to achieve considerable tax incentives in negotiations with host country. Considering that one MNC was granted considerable tax incentives from the Republic of Serbia (RS), the paper examines whether subsidiaries of MNCs have more favorable tax treatment of recorded income than domestic companies in the RS. Statistical analysis outcomes show that subsidiaries of MNCs do not have significantly lower income tax burden than domestic companies suggesting that tax incentives granted to MNCs from the RS are an exception rather than a rule. In addition, research showed that subsidiaries of MNCs primarily use tax incentives that are equally available to domestic companies, such as tax incentives for investment in fixed assets. Research results are robust to changes of income tax burden measures.
ASSESSMENT OF BALANCE IN YOUNGER SCHOOL AGE CHILDREN WITH INTELLECTUAL DISABILITY
Authors: Sretenović Ivana , Nedović Goran , Đorđević Srboljub
Published: January 2020

In children, balance develops in everyday activities through play and exercise. It is essential for learning, and participation in educational work and physical activities. The aim of the study was to evaluate the balance abilities of younger children with typical development and children with moderate intellectual disability. The survey was conducted on a sample of 38 male children (23 with typical development and 15 with moderate intellectual disability). To assess the balance we used Bruininks - Oseretsky Test of Motor Proficiency, 2nd edition - BOT 2 (Bruininks & Bruininks, 2005), subtest 5. Results show that total average achievement of children with typical development at all the tasks was 31.07, and 11.34 for children with intellectual disability. Statistically significant difference was achieved on 6 of 9 tasks (p <0.05). Compared to the norms, children with typical development are within the average, while respondents with moderate intellectual disabilities are below average on balance test. Obtained results of this study, can be used as a basis for further research in the field of (special) education and rehabilitation. They can be used to create programs of preventive and corrective work in order to support and assist students in school activities, also.
ATTACKING PERFORMANCE PROFILE OF FOOTBALL TEAMS IN DIFFERENT NATIONAL LEAGUES ACCORDING TO UEFA RANKINGS FOR CLUB COMPETITIONS
Authors: Leontijević Bojan , Janković Aleksandar , Tomić Lazar
Published: January 2020

The aim of this study was to compare the attacking performance profiles of the football teams playing in the national leagues of different rankings, defined on the basis of the Union of European Football Associations (UEFA) coefficient regarding club competitions. Applying the method of random sampling, one national league belonging to the first group – 4 participants in the Champions League and 3 teams participating in the Europa League (CL4+EL3; Germany), one belonging to the second group – CL3+EL3 (France), one belonging to the third group (CL2+EL3; Austria) and one from the fourth group – CL1+EL3 (Serbia) were selected. The analysis included all championship matches within the mentioned national competitions during the 2016/2017 season, which was a total of 1162 matches. The variables related to ball possession, passing game structure and efficacy and goal scoring attacks were monitored (19 variables in total). The results of this study have shown that there are significant differences in the organization of attacking games by the teams competing in the leagues of different rankings. It can be concluded that the players of the teams from the German and French leagues possess higher quality in technical and tactical sense, and are trained to play extremely fast, with a high degree of success in ball control.
POSSIBLE MODELS OF INTEGRATION OF PRESCHOOL MATHEMATICS AND PHYSICAL EDUCATION
Authors: Malinović-Jovanović Nela , Ristić Milica
Published: January 2020

The main goal of this paper is to suggest possible models of integration of preschool mathematics and physical education in accordance with characteristics of children’s cognitive development in this period, goals and objectives of preschool education and specifics of these subject areas in working with preschool children. It was investigated “why it is necessary to integrate teaching content of these specific subjects”, the different integration models, similar goals and learning objectives were specified, as well as appropriate types of integration suitable for linking the content of these subjects. Through the complete integration of related goals, as well as by observing mathematics through physical education, and physical education through mathematics, various possibilities of integrating teaching materials of these subjects are presented through specific examples as well as the appropriate instructions for their design. Integration of these subject areas is useful because due to the abstract nature of mathematical concepts, physical education allows children to learn about, explore and use to apply key mathematical concepts and language from another angle.
DIFFERENCES IN AGILITY AND EXPLOSIVE POWER OF BASKETBALL PLAYERS IN RELATION TO THEIR POSITIONS ON THE TEAM
Authors: Mitić Milan , Paunović Miloš , Živković Mladen , Stojanović Nikola , Bojić Ivana , Kocić Miodrag
Published: January 2020

Basketball is a sports game which consists of rapid changes in direction of movement, sudden stopping and starting for driving and dribbling and a great number of jumps. The various positions on a basketball team precisely determine the requirements for specific forms of movement, even though contemporary basketball strives for all players in all positions to possess the aforementioned abilities. A sample of 15 male basketball players, divided into three groups of five players each, based on their positions on the team, including the guard, forward and center position, was used to determine differences in agility (Agility T Test, Hexagon Agility Тest, Illinois Agility Test и Lane Agility Drill) and explosive power (the Squat jump, Countermovement Jump, Drop Jump and One-legged Counter Movement Jump). To determine the differences between the basketball players in relation to their positions on the team, the ANOVA analysis for independent samples was used as was a post-hoc analysis. The research results have indicated that there is a difference between the guard position compared to the forward and center position.
ECOTOURISM DEVELOPMENT IN SUNGAI JANIAH, AGAM: THE PARADIGMS FROM THE LOCAL COMMUNITY
Authors: Azwar Hendri , Pasaribu Pasaribu , Pramudia Heru
Published: January 2020

Ecotourism pays attention to conserved ecosystems with the aim of improving the welfare of local communities. Ecotourism development might have a positive impact on the natural, economic, social and cultural environment. Sungai Janiah is one of the tourist destinations in Agam Regency which has its own attraction that has the potential to become ecotourism. To support this, full support from the local community as a tourism agent is needed later. The purpose of this study is to identify and analyze local community surveys about ecotourism in the Sungai Janiah. This type of research is a quantitative descriptive study with survey methods. The research sample of 77 respondents were taken by purposive sampling technique by distributing questionnaires to families who settled in the Sungai Janiah. The data analysis technique used is descriptive analysis using score classification. The results showed 86% of the public strongly agreed that the Sungai Janiah would become ecotourism. Furthermore, in terms of environmental dimension, 89.61% of the respondents stated strongly agree, the Economic dimension 98.70% of the respondents strongly agreed, the cultural dimension 96.10% of the respondents strongly agreed, and the Social dimension 72.73% the respondents strongly agreed. From the results of the community survey, it is generally apparent that the community strongly agrees that the concept of ecotourism is suitable to be developed in the Sungai Janiah.
DAMPAK PENGGUNAAN JEJARING SOSIAL TERHADAP KARAKTER SISWA DI SEKOLAH DAARUL FIKRI
Authors: Zaenabiyah Nunung
Published: January 2020

Arus globalisasi memaksa seluruh negara dan lapisan masyarakat di dunia untuk menerima kenyataan masuknya pengaruh luar terhadap berbagai aspek kehidupan. Dampak dari globalisasi juga dapat mempengaruhi gaya hidup para remaja. Sebagai generasi masa kini yang lebih tertarik dengan adat negeri lain yang kenyataan nya tidak sesuai dengan adat istiadat dan kebiasaan bangsa kita. Pengaruh globalisasi terhadap anak muda saat ini begitu kuat. Saat ini anak muda kita kehilangan kepribadian diri sebagai bangsa Indonesia akibat pengaruh tersebut, globalisasi saat ini seperti boomerang yang jika pelempar tidak dapat menangkap boomerang yang telah dilempar dengan baik maka dapat melukai diri sendiri. Jejaring sosial adalah sebuah jejaring online yang para penggunanya dapat dengan mudah berinteraksi dan berbagi informasi satu sama lain tetapi memiliki efek negatif menjadikan ketergantungan para penggunanya. Untuk meminimalisir pengguna jejaring sosial dari hal-hal yang tidak baik dan merugikan, diharapkan kesadaran diri sendiri akan mampu menuntun pengguna situs tersebut dengan baik, khususnya anak dan remaja untuk dapat menggunakan teknologi dengan bijak dan dapat menyaring informasi yang baik maupun yang buruk yang terdapat pada era globalisasi saat ini. Penelitian ini menggunakan penelitian kuantitatif yang bertujuan untuk mengetahui pengaruh penggunaan jejaring sosial terhadap karakter siswa dengan instrument pengumpulan data berupa kuesioner, interview, dan dokumentasi kemudian diolah dengan SPSS v20. Teori yang menjadi rujukan pada penelitian ini diantaranya teori pendidikan karakter, teori jejaring sosial, dan teori pendidikan luar sekolah. Hasil temuan membuktikan bahwa jejaring sosial internet terbukti berpengaruh bagi karakter siswa siswi Sekolah  Daarul Fikri. Pentingnya peranan dari orang tua dan guru untuk bisa membimbing siswa di sekolah agar bijak dalam menggunakan jejaring sosial yang saat ini sangat diperlukan, karena selain memiliki dampak positif yang besar, jejaring sosial juga mempunyai dampak negatif yang besar pula.
Efektivitas Media Youtube Dalam Melestarikan Permainan Tradisional Dl LSM Bening Saguling Foundation di Desa Cihampelas
Authors: Tugino Tugino
Published: January 2020

Abstractthis research is based on background. The number of local wisdom that is almost extinct for example traditional games that have a good impact on the growth of children. As we see now, many children do not know the traditional game but know more about online games or what is on each gaget. This study aims to determine the process of managing YouTube's media, in preserving traditional games. The theory used in this study is the concept of PLS, Youtube, traditional games. The researcher formulated three questions related to the title raised, how the responses of the children in LSM Saguling Foundation. yotube media management in LSM  saguling foundation In this study researchers used descriptive methods and used a qualitative approach. Data collected through interviews, observation and documentation. As for the population of this study were children who were housed in the clear LSM Saguling Foundation. The results of this study children are less aware of traditional games and LSMplay an active role in preserving traditional games
Indigenous entrepreneurship in timber furniture manufacturing: The Gumatj venture in Northern Australia
Authors: L. Cecil A.
Published: January 2020

Despite commitment by the Australian Government to improve the economic independence of Indigenous people Aboriginals and Torres Strait Islanders they are the most socio economic disadvantaged group relative to other Australians. This commitment manifests in the four main strands of; 1) welfare, 2) installation of the Community Development Employment Projects (CDEP) scheme, 3) legislation enabling Traditional Land Owners and miners to negotiate agreements for training and employment of Indigenous people, and 4) programmes to encourage Indigenous entrepreneurship. This paper reports an Australian Indigenous entrepreneurial business (furniture making) initiated by the Gumatj clan of the Yolngu people in East Arnhem Land in the Northern Territory (NT) of Australia. These Indigenous people are employed in timber milling and transporting the milled timber to Gunyangara on the Gove Peninsula where it is dried and used to make furniture. Overcoming the literature documented barriers to Australian Indigenous entrepreneurship compelled the Gumatj to develop a business model with potential to foster pathways for other Indigenous small business endeavours.
Foods Promotion to Children: Understanding the Need of Responsibility in Marketing to Children
Authors: Kaur Pavleen
Published: January 2020

Children are bombarded with various forms of promotional activities by marketers of food products. It is known that children lack the necessary ability to understand that marketers direct promotions at them after a rigorous analysis of child psychology. They use simple criteria to evaluate products, get carried away by the use of cartoon characters, beautiful/irregular shapes or premiums offered to them. Therefore, relentless promotion often leads to overconsumption of nutrition poor and high density foods, leading to several health problems in children. Although parents also need to control food intake of their children or the government should intervene to check unethical practices of marketers, yet, their efforts are rendered unsuccessful if foods marketing companies themselves do not exercise self-restraint in marketing unhealthy foods to children and also market these foods â€˜heavilyâ€™. The present paper discusses these issues and seeks to attract interest of academicians, marketers and policy makers in India.