bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Base‐Oxidant Promoted Metal‐Free N‐Demethylation of Arylamines.
Authors: Botla Vinayak , Barreddi Chiranjeevi , Daggupati Ramana V. , Malapaka Chandrasekharam
Published: December 2016

The practical method tolerates a broad range of functionalized N,N‐dimethyl and N‐alkyl‐N‐methyl aniline derivatives, but fails using N‐methylmorpholine, N‐methyl‐9H‐carbazole or N‐methylaniline as a substrate.
ChemInform Abstract: Ligand‐Free Palladium‐Catalyzed Oxidative Carbonylative Homocoupling of Arylboron Reagents at Ambient Pressure.
Authors: Zhao Hongyuan , Han Wei
Published: December 2016

In contrast to traditional metal‐based oxidative systems the developed homo‐coupling of aryl boronic acids or potassium aryltrifluoroborates uses molecular oxygen or iodine as the oxidant, respectively.
ChemInform Abstract: Metal‐Catalyzed Formal Amidation of Alkenes under CO‐Free Condition.
Authors: Zhang Yuanyuan , Ye Wenjing , Leng Xue , He Ying , Zhang Hui , Xiao Xiao
Published: December 2016

Stilbenes react with the hypervalent iodine compound (II) as nitrogen source to give intermediate imines which undergo iron catalyzed conversion into various benzamides in the presence of air.
ChemInform Abstract: Visible Light‐Induced Radical Rearrangement to Construct C—C Bonds via an Intramolecular Aryl Migration/Desulfonylation Process.
Authors: Li Yuyuan , Hu Bei , Dong Wuheng , Xie Xiaomin , Wan Jun , Zhang Zhaoguo
Published: December 2016

The mild title method provides various N,2‐diarylacetamides in moderate to often high yields.
ChemInform Abstract: Palladium‐Catalyzed Enantioselective Three‐Component Synthesis of α‐Arylglycines.
Authors: Beisel Tamara , Diehl Andreas M. , Manolikakes Georg
Published: December 2016

An asymmetric three‐component coupling reaction of sulfonamides, glyoxylates, and areneboronic acids provides α‐arylglycines in high yields and excellent enantioselectivity.
ChemInform Abstract: Generation of Sulfonyl Radicals from Aryldiazonium Tetrafluoroborates and Sulfur Dioxide: The Synthesis of 3‐Sulfonated Coumarins.
Authors: Zheng Danqing , Yu Jiyao , Wu Jie
Published: December 2016

The reaction works well with aryl arylpropiolates Phenyl tert‐butylpropiolate does not react.
ChemInform Abstract: Novel One‐Pot Synthesis of Symmetrically Substituted Ureas.
Authors: Wu Xingxing , Niu Qingfen , Li Tianduo
Published: December 2016

The simple and environmentally friendly protocol proceeds with inexpensive reagents.
ChemInform Abstract: Branched Arylalkenes from Cinnamates: Selectivity Inversion in Heck Reactions by Carboxylates as Deciduous Directing Groups.
Authors: Tang Jie , Hackenberger Dagmar , Goossen Lukas J.
Published: December 2016

A decarboxylative Mizoroki—Heck coupling of aryl halides with cinnamic acids is presented in which the carboxylate group directs the arylation into its β‐position before being tracelessly removed through protodecarboxylation.
ChemInform Abstract: Highly Modulated Bisindoles: Ligands for Copper‐Catalyzed Sonogashira Reaction.
Authors: Wang Xiu , Wang Zhenhua , Wu Ya , Luo Yanlong , Zhang Guofang , Jian Yajun , Sun Huaming , Zhang Weiqiang , Gao Ziwei
Published: December 2016

The novel N,N′‐ligand (BSI) is air‐stable, easily available and highly modulated with low copper loading.
ChemInform Abstract: RhI‐Catalyzed Intramolecular Carbonylative C—H/C—I Coupling of 2‐Iodobiphenyls Using Furfural as a Carbonyl Source.
Authors: Furusawa Takuma , Morimoto Tsumoru , Nishiyama Yasuhiro , Tanimoto Hiroki , Kakiuchi Kiyomi
Published: December 2016

Fluorenones (III) are synthesized through intramolecular carbonylative C—H/C—I coupling of 2‐iodobiphenyls (I) using furfural (II) as a carbonyl source and the combination of [RhCl(cod)]2 and DPPP as catalyst.
ChemInform Abstract: Copper‐Catalyzed Cyanoalkylative Cycloetherification of Alkenes to 1,3‐Dihydroisobenzofurans: Development and Application to the Synthesis of Citalopram.
Authors: Ha Tu M. , Wang Qian , Zhu Jieping
Published: December 2016

A series of 1,3‐dihydroisobenzofurans (III) is readily prepared by copper‐catalyzed reaction of (2‐vinylaryl)methanols (I) with acetonitrile.
ChemInform Abstract: TiCl4‐Mediated Preparation of Thiophthalide Derivatives via Formal Thio‐Passerini Reactions.
Authors: Ponra Sudipta , Nyadanu Aude , El Kaim Laurent , Grimaud Laurence , Vitale Maxime R.
Published: December 2016

A formal extension of the Passerini reaction to thiocarbonyls leads to thiophthalides via intermediate formation of a sulfanyl‐phthalide followed by insertion of isocyanide.
ChemInform Abstract: Selective Mono‐Reduction of Pyrrole‐2,5‐ and ‐2,4‐dicarboxylates.
Authors: Yasui Eiko , Tsuda Jyunpei , Ohnuki Satoshi , Nagumo Shinji
Published: December 2016

The title compounds are rapidly and selectively reduced to the corresponding mono‐alcohols using diisobutylaluminum hydride as reductant.
ChemInform Abstract: Synthesis of (1H‐Pyrrol‐1‐yl)anthracene‐9,10‐diones.
Authors: Zvarych Viktor I. , Stasevych Maryna V. , Lunin Volodymyr V. , Vovk Mykhailo V. , Novikov Volodymyr P.
Published: December 2016

The title compounds are prepared from (amino)anthracenediones and (dimethoxy)tetrahydrofuran via Clauson—Kaas reaction using I2 as catalyst.
ChemInform Abstract: A Dual‐Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes.
Authors: Lin Jin‐Shun , Dong Xiao‐Yang , Li Tao‐Tao , Jiang Na‐Chuan , Tan Bin , Liu Xin‐Yuan
Published: December 2016

The first catalytic asymmetric aminotrifluoromethylation of alkenes by using Togni′s reagent (II) has been developed.
ChemInform Abstract: Reactivity of 1‐Arylnitrosoethylenes Towards Indole Derivatives.
Authors: Lopes Susana M. M. , Nunes Sandra C. C. , Caratao Catia C. , Pais Alberto A. C. C. , Pinho e Melo Teresa M. V. D.
Published: December 2016

Indole (II) and 1‐methylindole (VII) react with 1‐arylnitrosoethylene leading to intermediate hetero‐Diels—Alder cycloadducts, which suffer an 1,2‐oxazine ring‐opening reaction to form 3‐alkylated indoles.
ChemInform Abstract: Indoline‐Based Constrained Peptidomimetic Motifs Obtained via the Joullie—Ugi Reaction of Indolenines.
Authors: Golubev Pavel , Bakulina Olga , Dar'in Dmitry , Krasavin Mikhail
Published: December 2016

Sterically demanding indolenines are employed as cyclic imine substrates in the title reaction with isocyanides and carboxylic acids, resulting in a new type of conformationally constrained indoline‐based peptidomimetics.
ChemInform Abstract: Trifluoroacetylation of Indole‐Chalcones Derived from the 2‐Amino‐3‐(arylethynyl)‐5‐bromo‐iodochalcones.
Authors: Mphahlele Malose J. , Maluleka Marole M.
Published: December 2016

An endo‐dig cyclization of 2‐amino 3‐arylethynyl chalcones provides indole‐chalcones.
ChemInform Abstract: Synthesis, Characterization and Application of Ni0.5Zn0.5Fe2O4 Nanoparticles for the One Pot Synthesis of Triaryl‐1H‐imidazoles.
Authors: Khazaei Ardeshir , Alavi Nik Heidar Ali , Ranjbaran Azam , Moosavi‐Zare Ahmad Reza
Published: December 2016

The title nanoparticles catalyze the one‐pot, three‐component reaction of 1,2‐diketones, aryl aldehydes, and NH4OAc under solvent‐free conditions providing triaryl‐1H‐imidazoles in good to excellent yields.
ChemInform Abstract: Synthesis of 5‐Hydroxy Hydantoins via a Tandem Process.
Authors: Meza‐Leon Rosa Luisa , Bernes Sylvain , Cortes‐Lopez Guadalupe Nallely , Mastranzo Virginia M. , Sosa‐Rivadeneyra Martha , Sartillo‐Piscil Fernando
Published: December 2016

The reaction of α‐keto acids with carbodiimides provides O‐acyl urea intermediates which undergo visible light induced rearrangement to form unexpected hydantoine derivatives.
ChemInform Abstract: Synthesis of Novel 5‐Arylidenethiazolidinones with Apoptotic Properties via a Three Component Reaction Using Piperidine as a Bifunctional Reagent.
Authors: Bathula Chandramohan , Tripathi Sayantan , Srinivasan Ramprasad , Jha Kunal Kumar , Ganguli Arnab , Chakrabarti G. , Singh Shailja , Munshi Parthapratim , Sen Subhabrata
Published: December 2016

A typical three component reaction strategy towards the synthesis of 5‐arylidenethiazolidinone compounds from thiazolidine‐2,4‐dione, piperidine, and appropriate aldehydes is described.
ChemInform Abstract: An Efficient PEG‐400 Mediated Catalyst Free Green Synthesis of 2‐Amino‐thiazoles from α‐Diazoketones and Thiourea.
Authors: Babu B. Hari , Vijay K. , Murali Krishna K. Bala , Sharmila N. , Ramana M. Baby
Published: December 2016

The catalyst‐free method tolerates alkyl and aryl substituted α‐diazoketones and delivers the products in high yields.
ChemInform Abstract: Synthesis and Cytotoxicity Evaluation of Aryl Triazolic Derivatives and Their Hydroxymethine Homologues Against B16 Melanoma Cell Line.
Authors: Kalhor‐Monfared Shiva , Beauvineau Claire , Scherman Daniel , Girard Christian
Published: December 2016

A wide range of triazole derivatives (III) (72 examples) are synthesized via copper(I)‐catalyzed alkyne‐azide cycloaddition reaction.
ChemInform Abstract: Synthesis of Pyranopyrazoles Using a Magnetically Separable Modified Preyssler Heteropoly Acid.
Authors: Javid Ali , Khojastehnezhad Amir , Eshghi Hossein , Moeinpour Farid , Bamoharram Fatemeh F. , Ebrahimi Javad
Published: December 2016

The title compounds are prepared by multicomponent reaction of benzaldehydes, ethyl acetoacetate, malononitrile, and hydrazine hydrate using Preyssler acid supported on silica‐coated nickel ferrite magnetic nanoparticles as catalyst.
ChemInform Abstract: Palladium—Copper Catalyzed C(sp3)—C(sp2) Bond C—H Activation Cross‐Coupling Reaction: Selective Arylation to Synthesize 9‐Aryl‐9H‐xanthene and 9,9‐Diaryl‐xanthene Derivatives.
Authors: Shen Guodong , Zhao Lingyu , Wang Yichen , Xia Wenfang , Yang Mingsen , Zhang Tongxin
Published: December 2016

The Pd/Cu‐catalyzed reaction of xanthenes (I) with arenes (II) gives rise to 9‐aryl‐9H‐xanthenes (III) or 9,9‐diaryl‐xanthenes (VI) depending on the reaction time and temperature.
ChemInform Abstract: Synthesis of α‐Acyloxynitrones and Reactivity Towards Samarium Diiodide.
Authors: Racine Emilie , Burchak Olga N. , Py Sandrine
Published: December 2016

The synthesis of new nitrones such as (VII) from (D)‐fructose demonstrates that acyl‐protected nitrones can be prepared efficiently by intramolecular N‐alkylation of sugar‐derived oximes, a strategy previously developed only for ether‐ or ketal‐protected cyclic nitrones.
ChemInform Abstract: One‐Pot Synthesis of Hantzsch Pyridines via NH4I Promoted Condensation of 1,3‐Dicarbonyl Compounds with DMSO and NH4OAc.
Authors: Chang Liming , Lai Junyi , Yuan Gaoqing
Published: December 2016

In this entitled synthesis, DMSO serves not only as an efficient solvent, but also as a source of one‐carbon synthon to the pyridine ring.
ChemInform Abstract: Cu‐Catalyzed Deoxygenative C2‐Sulfonylation Reaction of Quinoline N‐Oxides with Sodium Sulfinate.
Authors: Du Bingnan , Qian Ping , Wang Yang , Mei Haibo , Han Jianlin , Pan Yi
Published: December 2016

A reductive sulfonylation of quinoline N‐oxides with sodium sulfinates by using a radical initiator is presented with good yields.
ChemInform Abstract: Catalyst‐Controlled Selectivity in the Synthesis of C2‐ and C3‐Sulfonate Esters from Quinoline N‐Oxides and Aryl Sulfonyl Chlorides.
Authors: Ying Beibei , Xu Jun , Zhu Xiaolei , Shen Chao , Zhang Pengfei
Published: December 2016

C2‐ and C3‐Sulfonate esters [(III) and (IV)] are selectively synthesized starting from quinoline N‐oxides (I) and aryl sulfonyl chlorides (II).
ChemInform Abstract: Synthesis of 4‐Aryl‐2‐pyranyl‐7,8‐dihydroquinolin‐5(6H)‐ones Catalyzed by Cerium Ammonium Nitrate via Hantzsch Multicomponent Reaction and Their Antibacterial Activity.
Authors: Satish Gudala , Sharma Archi , Gadidasu Kranthi Kumar , Vedula Rajeswar Rao , Penta Santhosh
Published: December 2016

A green method is developed for synthesis of the title compounds using a Hantzsch‐type multicomponent reaction in water.
ChemInform Abstract: Hydroquinolines via the Hantzsch Reaction Promoted by SiO2‐I.
Authors: Ahad Abdul , Farooqui Maqdoom
Published: December 2016

Silica iodide proves to be an excellent catalyst for the Hantzsch‐type four component synthesis of hydroquinolines under mild, solvent‐free conditions.
ChemInform Abstract: Asymmetric Synthesis of Fused Polycyclic Indazoles Through Aminocatalyzed Aza‐Michael Addition/Intramolecular Cyclization.
Authors: Giardinetti Maxime , Marrot Jerome , Moreau Xavier , Coeffard Vincent , Greck Christine
Published: December 2016

Further transformation of the products′ aldehyde moiety via Wittig‐reaction or reductive amination is exemplified.
ChemInform Abstract: Thermal Cycloisomerization of Putative Allenylpyridines for the Synthesis of Isoquinoline Derivatives.
Authors: Morrison Alec E. , Hrudka Jeremy J. , Dudley Gregory B.
Published: December 2016

A benzannulation of [5‐(phenylthio)pent‐4‐enyl]pyridinylacetylenes yields cyclopentaisoquinolines via a cascade process.
ChemInform Abstract: Decarboxylative [4 + 1] Oxidative Annulation of Malonate Monoesters with 2‐Vinylpyridine Derivatives.
Authors: Tang Shan , Gao Xinlong , Lei Aiwen
Published: December 2016

2‐Vinylpyridines or related N‐heterocycles participate with both malonate monoesters and cyanoacetic acid in a NIS‐mediated decarboxylative [4 + 1] oxidative annulation reaction.
ChemInform Abstract: One‐Pot and Step‐Wise Synthesis of Thieno[3,2‐c]pyridin‐4‐ones.
Authors: Sahu Satya Narayan , Singh Surjeet , Shaw Ranjay , Shally Shally , Ram Vishnu Ji , Pratap Ramendra
Published: December 2016

The reaction of nitriles (I) with methyl mercaptoacetate (II) gives rise to intermediate thieno[3,2‐c]pyran‐4‐ones, which react with hydrazine hydrate to afford desired thieno[3,2‐c]pyridin‐4‐ones (III).
ChemInform Abstract: Efficient and Convenient Synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐dione Derivatives Mediated by L‐Proline.
Authors: Roy Harendra Nath , Rana Masud , Munsur Abu Zafar Al , Lee Kee‐In , Sarker Ashis K.
Published: December 2016

An environmentally friendly, four‐component, one‐pot condensation reaction of phthalimide or phthalic anhydride, various aromatic aldehydes, ethylcyanoacetate, and hydrazine hydrate is presented.
ChemInform Abstract: A Cascade Reaction of O‐Alkenylphenyl Carbodiimides with Isocyanides by Copper Catalysis: Direct Construction of 4,5‐Dihydroimidazo[1,5‐a]quinazolines.
Authors: Hao Wenyan , Sang Xiaoyan , Xiao Yunsheng , Cai Mingzhong
Published: December 2016

The Cu‐catalyzed reaction of ortho‐alkenyl substituted phenyl carbodiimides (I) with isocyanoacetate (II) initially proceeds through a [3 + 2] cycloaddition followed by an intramolecular conjugate addition annulation to give the title compounds (III) in moderate to good yields.
ChemInform Abstract: Aerobic Oxidative Carbonylation of Enamides by Merging Palladium with Photoredox Catalysis.
Authors: Liu Kun , Zou Minzhu , Lei Aiwen
Published: December 2016

The scalable method represents a mild, environmentally benign access to 1,3‐oxazin‐6‐ones.
ChemInform Abstract: Arylboration of 1‐Arylalkenes by Cooperative Nickel/Copper Catalysis.
Authors: Semba Kazuhiko , Ohtagaki Yasuhiro , Nakao Yoshiaki
Published: December 2016

The Ni/Cu‐catalyzed reaction of 1‐arylalkenes with aryl chlorides and bis(pinacolato)diboron proceeds readily to afford 2‐boryl‐1,1‐diarylalkanes (IVa‐i), whilst the analogous reaction with 1‐octene fails.
ChemInform Abstract: Metal Free Synthesis of Diaryl Selenides Using SeO2 as a Selenium Source.
Authors: Kumar R. Uday , Reddy K. Harsha Vardhan , Satish G. , Swapna K. , Nageswar Y. V. D.
Published: December 2016

A simple and environmentally benign protocol is developed for the synthesis of diarylselenium compounds from arylboronic acids and SeO2.
ChemInform Abstract: New Catalytic Method for the Synthesis of β‐Hydroxy Selenides.
Authors: Zhang Yikun , Wu Sixue , Yan Jie
Published: December 2016

The in‐situ generated reactive electrophilic Se species reacts with several alkenes (I) furnishing β‐hydroxy selenides in moderate to good yields.
ChemInform Abstract: Isolation of Lingzhifuran A and Lingzhilactones D—F from Ganoderma lucidum as Specific Smad3 Phosphorylation Inhibitors and Total Synthesis of Lingzhifuran A.
Authors: Ding Wei‐Yi , Ai Jun , Wang Xin‐Long , Qiu Fayang G. , Lv Qing , Fang Ping , Hou Fan‐Fan , Yan Yong‐Ming , Cheng Yong‐Xian
Published: December 2016

The four new phenolic meroterpenoids, lingzhifuran A (I) and lingzhilactones D—F (II—IV), show inhibitory activities against transforming growth factor‐β1‐induced Smad3 phosphorylation.
ChemInform Abstract: Two New Ring A‐Cleaved Lanostane‐Type Triterpenoids and Four Known Steroids Isolated from Endophytic Fungus Glomerella sp. F00244.
Authors: Guo Kai , Fang Huiqin , Gui Fu , Wang Yuezhou , Xu Qinyan , Deng Xianming
Published: December 2016

isolation, structure elucidation, antimicrobial and cytotoxic activities of two new triterpenoids, called glometenoid A (I) and glometenoid B (II), together with four known ergostane‐type steroids
ChemInform Abstract: A Synthesis of (.+‐.)‐Aplydactone.
Authors: Meier Robin , Trauner Dirk
Published: December 2016

A total synthesis of the unusual brominated sesquiterpenoid aplydactone I is presented that relies on two non‐biomimetic, highly effective photochemical key steps establishing the two cyclobutane rings.
ChemInform Abstract: Three New Abietane‐Type Diterpenes from the Bark of Cryptomeria japonica.
Authors: Chang Chi‐I , Chen Chien‐Chih , Wang Sheng‐Yang , Chao Che‐Yi , Chao Louis Kuoping , Chen Jih‐Jung , Ko Horng‐Huey , Chen Cheng‐Chi , Kuo Yueh‐Hsiung
Published: December 2016

isolation and structure elucidation
ChemInform Abstract: Four New Steroidal Glycosides, Protolinckiosides A—D, from the Starfish Protoreaster lincki
Authors: Malyarenko Timofey V. , Kicha Alla A. , Kalinovsky Anatoly I. , Ivanchina Natalia V. , Popov Roman S. , Pislyagin Evgeny A. , Menchinskaya Ekaterina S. , Padmakumar Krishna Pillai , Stonik Valentin A.
Published: December 2016

[isolation, structure elucidation and bioactivity of the title steroidal glycosides, cf.
ChemInform Abstract: Aloeverasides A and B: Two Bioactive C‐Glucosyl Chromones from Aloe vera Resin.
Authors: Rehman Najeeb Ur , Hussain Hidayat , Khiat Mohammed , Al‐Riyami Samia Ahmed , Csuk Rene , Khan Husain Yar , Abbas Ghulam , Al‐Thani Ghanim Salim , Green Ivan R. , Al‐Harrasi Ahmed
Published: December 2016

The title compounds (I) display good urease enzyme inhibition activities, significant growth inhibition of the breast cancer cell line MDA‐MB‐231 as well as good antioxidant activities.
ChemInform Abstract: Fissitungfines A and B, Two Novel Aporphine Related Alkaloids from Fissistigma tungfangense
Authors: Zhou Qi , Fu Yan‐Hui , Zhang Yu‐Qin , Wu Shou‐Yuan , Song Xiao‐Ping , Cao Cheng‐Ke , Xu Wei , Chen Guang‐Ying
Published: December 2016

isolation, structure elucidation, plausible biogenetic pathway and biological activities
ChemInform Abstract: Spirobisnaphthalenes and Lactones from the Seeds of Strychnos angustiflora with Potential Antiinflammatory Activity.
Authors: Jiang Hua , Ma Shuang‐Gang , Li Yong , Liu Yun‐Bao , Li Li , Qu Jing , Yu Shi‐Shan
Published: December 2016

The isolation of palmarumycin SA1 (I), palmarumycin SA2 (IIa), palmarumycin SA3 (IIb), preussomerin SA1 (III), (+)‐7‐hydroxylasiodiplodin (IVa) and (+)‐7‐hydroxylasiodiplodin (IVb) is described and biological evaluation shows promising anti‐inflammatory activity of compound (I).
ChemInform Abstract: Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]‐Spirohemiaminals from the Combined‐Culture of Streptomyces nigrescens and Tsukamurella pulmonis.
Authors: Sugiyama Ryosuke , Nishimura Shinichi , Ozaki Taro , Asamizu Shumpei , Onaka Hiroyasu , Kakeya Hideaki
Published: December 2016

Streptoaminal‐9n (I) and its enantiomer (II) show antibacterial activity.
ChemInform Abstract: Clindanones A and B and Cladosporols F and G, Polyketides from the Deep‐Sea Derived Fungus Cladosporium cladosporioides HDN14‐342.
Authors: Zhang Zhenzhen , He Xueqian , Liu Congcong , Che Qian , Zhu Tianjiao , Gu Qianqun , Li Dehai
Published: December 2016

Cladosporol G (I), together with another three new tetralone derivatives and three known biogenetically related polyketides, is isolated from title deep‐sea derived fungus and is shown to have the best cytotoxic activity against HeLa cells with an IC50 value of 3.9 μM.
ChemInform Abstract: Lecanicillones A—C, Three Dimeric Isomers of Spiciferone A with a Cyclobutane Ring from an Entomopathogenic Fungus Lecanicillium sp. PR‐M‐3.
Authors: Bai Jiao , et al.
Published: December 2016

Lecanicillones A—C (I—III) are isolated from an entomopathogenic fungus Lecanicillium sp.
ChemInform Abstract: Enhanced Optical and Electrical Properties of Polymer‐Assisted All‐Inorganic Perovskites for Light‐Emitting Diodes.
Authors: Ma Biwu , et al.
Published: December 2016

CsPbBr3 perovskite thin films are prepared by spin coating of a DMSO solution of poly(ethylene oxide) (PEO) and CsPbBr3 (molar ratios of 0.065—0.259:1) followed by annealing (70 °C, 5 min).
ChemInform Abstract: Characteristics and Reactivity of Ruthenium‐Oxo Complexes
Authors: Ishizuka Tomoya , Kotani Hiroaki , Kojima Takahiko
Published: December 2016

Review: 240 refs.
ChemInform Abstract: Carbon‐Hydrogen to Carbon‐Phosphorus Transformations
Authors: Montchamp Jean‐Luc
Published: December 2016

Review: literature published between 2008 and 2013; 97 refs.
ChemInform Abstract: Fundamental and Applied Properties of Borocations
Authors: Ingleson Michael J.
Published: December 2016

Review: synthetic utility of borocations as stoichiometric reagents and catalysts; 121refs.
ChemInform Abstract: The Catalytic Dehydrocoupling of Amine‐Boranes and Phosphine‐Boranes
Authors: Johnson Heather C. , Hooper Thomas N. , Weller Andrew S.
Published: December 2016

Review: 181 refs.
ChemInform Abstract: Reagent‐Controlled Lithiation‐Borylation
Authors: Leonori Daniele , Aggarwal Varinder K.
Published: December 2016

Review: 57 refs.
ChemInform Abstract: Halogen Bonding in the Design of Organic Phosphors
Authors: Pang Xue , Jin Wei Jun
Published: December 2016

Review: 47 refs.
ChemInform Abstract: Excitation of Nucleobases from a Computational Perspective II: Dynamics
Authors: Mai Sebastian , Richter Martin , Marquetand Philipp , Gonzalez Leticia
Published: December 2016

Review: 119 refs.
ChemInform Abstract: Excitation of Nucleobases from a Computational Perspective I: Reaction Paths
Authors: Giussani Angelo , Segarra‐Marti Javier , Roca‐Sanjuan Daniel , Merchan Manuela
Published: December 2016

Review: 8163 refs.].
ChemInform Abstract: Zirconocene‐Assisted Remote Cleavage of C—C and C—O Bonds: Application to Acyclic Stereodefined Metalated Hydrocarbons
Authors: Bruffaerts J. , Pierrot D. , Marek I.
Published: December 2016

Review: [19 refs.
ChemInform Abstract: Aniline‐Terephthalaldehyde Resin p‐toluenesulfonate (ATRT) as a Highly Efficient and Reusable Catalyst for Alcoholysis, Hydrolysis, and Acetolysis of Epoxides
Authors: Tanemura Kiyoshi , Suzuki Tsuneo
Published: December 2016

Review: 38 refs.
ChemInform Abstract: Replacement of Dialkyl Amino Group on D—A Type Fluorophores to Increase the Brightness
Authors: Kim Eunha
Published: December 2016

Review: 14 refs.
ChemInform Abstract: Substrate and Catalyst Effects in C—H Insertion Reactions of α‐Diazoacetamides
Authors: Ring Aoife , Ford Alan , Maguire Anita R.
Published: December 2016

Review: 66 refs.
ChemInform Abstract: Diazonaphthoquinones: Synthesis, Reactions and Applications
Authors: Kitamura Mitsuru , Othman I. A. Dina
Published: December 2016

Review: [37 refs.
ChemInform Abstract: Monosubstituted Cyclodextrins as Precursors for Further Use
Authors: Rezanka Michal
Published: December 2016

Review: 169 refs.
ChemInform Abstract: Simple Marine 1‐Deoxysphingoid Bases: Biological Activity and Syntheses
Authors: Martinkova Miroslava , Gonda Jozef , Jackova Dominika
Published: December 2016

Review: [88 refs.
ChemInform Abstract: Fluorinated Diazoalkanes — A Versatile Class of Reagents for the Synthesis of Fluorinated Compounds
Authors: Mertens Lucas , Koenigs Rene M.
Published: December 2016

Review: 79 refs.
ChemInform Abstract: Recent Application of Oxa‐Michael Reaction in Complex Natural Product Synthesis
Authors: Hu Jialei , Bian Ming , Ding Hanfeng
Published: December 2016

Review: [87 refs.
ChemInform Abstract: Recent Advances in Aerobic Oxidation with Ruthenium Catalysts
Authors: Muthusamy Subramaniam , Kumarswamyreddy Nandarapu , Kesavan Venkitasamy , Chandrasekaran Srinivasan
Published: December 2016

Review: [91 refs.
ChemInform Abstract: Total Synthesis of Pallavicinia Diterpenoids: An Overview
Authors: Bian Yi‐Chao , Peng Xiao‐Shui , Wong Henry N.C.
Published: December 2016

Review: [25 refs.
ChemInform Abstract: Bicyclic Aziridinium Ions in Azaheterocyclic Chemistry ‐ Preparation and Synthetic Application of 1‐Azoniabicyclo[n.1.0]alkanes
Authors: Dolfen Jeroen , Yadav Nagendra Nath , De Kimpe Norbert , D'hooghe Matthias , Ha Hyun‐Joon
Published: December 2016

Review: [56 refs.
ChemInform Abstract: Cooperative Catalysis and Activation with N‐Heterocyclic Carbenes
Authors: Wang Michael H. , Scheidt Karl A.
Published: December 2016

Review: [79 refs.
ChemInform Abstract: Novel Nitrogen‐, Phosphorus‐Containing Sterically Hindered Phenols
Authors: Azmukhanova R. R. , Gibadullina E. M. , Nguyen T. T. , Burilov A. R. , Pudovick M. A.
Published: December 2016

Review: 9 refs.
ChemInform Abstract: Cyclobutenes: At a Crossroad Between Diastereoselective Syntheses of Dienes and Unique Palladium‐Catalyzed Asymmetric Allylic Substitutions
Authors: Misale Antonio , Niyomchon Supaporn , Maulide Nuno
Published: December 2016

Review: 84 refs.
ChemInform Abstract: Opportunities for Glyconanomaterials in Personalized Medicine
Authors: Reichardt Niels‐Christian , Martin‐Lomas Manuel , Penades Soledad
Published: December 2016

Review: 95 refs.
ChemInform Abstract: Synthesis of Ciprofloxacin‐Based Compounds: A Review
Authors: Akhtar Rabia , Yousaf Muhammad , Naqvi Syed Ali Raza , Irfan Muhammad , Zahoor Ameer Fawad , Hussain Abdullah Ijaz , Chatha Shahzad Ali Shahid
Published: December 2016

Review: 71 refs.
ChemInform Abstract: GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus: The Biological Characteristics and the Chemical Space
Authors: Chen Cheng , Li He , Long Ya‐Qiu
Published: December 2016

Review: 67 refs.
ChemInform Abstract: Hole‐Transport Materials for Perovskite Solar Cells
Authors: Calio Laura , Kazim Samrana , Graetzel Michael , Ahmad Shahzada
Published: December 2016

Review: 138 refs.
ChemInform Abstract: 2D Materials for Renewable Energy Storage Devices: Outlook and Challenges
Authors: Sahoo Ramkrishna , Pal Anjali , Pal Tarasankar
Published: December 2016

Review: 199 refs.
Numerical investigation of two phase flow in micromodel porous media: Effects of wettability, heterogeneity, and viscosity
Authors: Maaref Sepideh , Rokhforouz Mohammad‐Reza , Ayatollahi Shahab
Published: December 2016

The aim of the present work is to assess the effects of wettability, heterogeneity, and viscosity differences on water‐oil displacement process in micromodel porous media through numerical modelling. The two‐phase flow was simulated by Cahn‐Hilliard phase field method (PFM) using a finite element package. The micromodel was initially saturated with oil (wetting phase) and oil was produced through invasion of the displacing phase into the matrix. The computed oil and water saturations were in good agreement with those obtained by the visual flooding experiment. Using the validated model, sensitivity analysis was performed to investigate the effects of different wettability states, heterogeneity, and viscosity on the displacement process. The obtained results showed that the final oil saturation of the homogeneous pattern is 0.37 which is 13 % less than that of the heterogeneous one. For the highly oil‐wet medium (), the capillary forces prevented water to invade more pore bodies and resulted in 0.62 ultimate oil saturation; however, the final oil saturation in the neutral wet () was ∼0.5. Increasing the viscosity of displacing agent formed lower channelling and fingering which led to higher oil recovery due to the favourable mobility ratio. The present study demonstrates that PFM can be a reliable approach to capture micro‐ and macro‐scale mechanisms in the simulation of immiscible two‐phase flow in micromodel porous media with a reasonable computational time.
Verification of sound insulation in residential building – the new DIN 4109 / Nachweis des Schallschutzes im Wohnungsbau – die neue DIN 4109
Authors: Meier Andreas
Published: December 2016

The central sound insulation standard for building in Germany, DIN 4109, was issued in a revised version in July 2016. The calculation procedures described in the standard can now be used to verify constructional sound insulation for masonry buildings with insulated external walls. For other building materials and construction methods, the minimum requirements can be verified, or if required the enhanced requirements. Measurements in completed buildings confirm the results and show that provided the construction materials are suitable and the specialist design is correct, good sound protection is regularly achieved.
The ecohydrological vulnerability of a large inland delta to changing regional streamflows and upstream irrigation expansion
Authors: Hassanzadeh Elmira , Elshorbagy Amin , Nazemi Ali , Jardine Timothy D. , Wheater Howard , Lindenschmidt Karl‐Erich
Published: December 2016

Future climate change and anthropogenic interventions can alter historical streamflow conditions and consequently degrade the health and biodiversity of freshwater ecosystems. Future ecohydrological threats, however, are difficult to quantify using the cascade of climate and hydrological models due to various uncertainties involved. This study instead uses a fully bottom‐up approach to evaluate the ecohydrological vulnerability of the Saskatchewan River Delta (SRD), the largest inland delta in North America, to changing streamflow regime and irrigation expansion. An ensemble of perturbed streamflow sequences, along with scenarios of current and expanded irrigation, was generated and fed into a regional water resource system model. Results show that the streamflow regime in the delta is more sensitive to upstream changes in annual flow volume than peak flow timing and/or irrigation expansion. The sensitivity to changes in flow volume, however, may be intensified when combined with changes in peak timing. Shifts in the upstream peak flow timing can alter the magnitude and timing of peak flow to the delta, with prime importance to aquatic biota that are adapted to historical rhythmicity in peak flows and timing. Irrigation expansion decreases the magnitude and frequency of the peak flows, alters the frequency of average and low flows, and slightly shifts the timing of the mean annual peak flow in the SRD. This can lead to isolation of lakes and wetlands from the main stream. Our results highlight the ecohydrological vulnerability of the SRD under potential changing conditions and can assist in proposing adaptation policies to protect this ecosystem.
Sugars and fat – A healthy way to generate functional regulatory T cells
Authors: Gabriel Sarah Sharon , Kallies Axel
Published: December 2016

Cellular metabolism has emerged as an important regulator of adaptive immunity. While the metabolic requirements of conventional T cells are increasingly understood, the role of cellular metabolism in Foxp3+ regulatory T (Treg) cells is less clear. Although it is well accepted that repression of Akt/mTOR, HIF‐1α and aerobic glycolysis are important for the efficient generation of Treg cells in vitro, clear evidence how these pathways impact on Treg‐cell development in vivo is limited. Furthermore, newer studies have shown that the same pathways that appear to suppress Treg‐cell development are active in and required for functionally mature Treg cells. Thus, it becomes increasingly evident that development and function of regulatory T cells require different wiring of metabolic pathways. Finally, it is likely that critical differences remain to be uncovered between the metabolism of resting or ‘naïve’ Treg cells and those fully differentiated and actively engaged in suppression. In this comment, we briefly discuss our current understanding of Treg‐cell metabolism and the need to address this area with new approaches based on in vivo models.
Late quaternary speleogenesis and landscape evolution in the northern Apennine evaporite areas
Authors: Columbu Andrea , Chiarini Veronica , De Waele Jo , Drysdale Russell , Woodhead Jon , Hellstrom John , Forti Paolo
Published: December 2016

Gypsum beds host the majority of the caves in the north‐eastern flank of the Apennines, in the Emilia Romagna region (Italy). More than six hundred of these caves have been surveyed, including the longest known epigenic gypsum cave systems in the world (Spipola‐Acquafredda, ~11 km). Although this area has been intensively studied from a geological point of view, the age of the caves has never been investigated in detail. The rapid dissolution of gypsum and uplift history of the area have led to the long‐held view that speleogenesis commenced only during the last 130 000 years.

Epigenic caves only form when the surface drainage system efficiently conveys water into the underground. In the study area, this was achieved after the dismantling of most of the impervious sediments covering the gypsum and the development of protovalleys and sinkholes. The time necessary for these processes can by constrained by understanding when caves were first formed.

The minimum age of karst voids can be indirectly estimated by dating the infilling sediments. U–Th dating of carbonate speleothems growing in gypsum caves has been applied to 20 samples from 14 different caves from the Spipola‐Acquafredda, Monte Tondo‐Re Tiberio, Stella‐Rio Basino, Monte Mauro, and Castelnuovo systems. The results show that: (i) caves have been forming since at least ~600 kyr ago; (ii) the peak of speleogenesis was reached during relatively cold climate stages, when rivers formed terraces at the surface and aggradation caused paragenesis in the stable cave levels; (iii) ~200 000 years were necessary for the dismantling of most of the sediments covering the karstifiable gypsum and the development of a surface mature drainage network.

Besides providing a significant contribution to the understanding of evaporite karst evolution in the Apennines, this study refines our knowledge on the timescale of geomorphological processes in a region affected by rapid uplifting. Copyright © 2016 John Wiley & Sons, Ltd.
PhI Catalyzed Acetoxyselenylation and Formyloxyselenylation of Alkenes
Authors: Zhang Yikun , Wu Sixue , Yan Jie
Published: December 2016

With PhI as catalyst and mCPBA as oxidant, a novel and efficient catalytic procedure has been developed for the acetoxyselenylation and formyloxyselenylation of alkenes. In this protocol, PhI is first oxidized into hypervalent iodine intermediate, which promotes the cleavage of Se–Se bond in diselenides. The in situ generated electrophilic selenium species then reacts with alkenes, affording 2‐acetoxy‐1‐selenides and 2‐formyloxy‐1‐selenides in high regioselectivity and good yields.
Calmodulin Regulated Spectrin Associated Protein 1 mRNA is Directly Regulated by miR‐126 in Primary Human Osteoblasts
Authors: Strassburg Sandra , Nabar Nikita , Lampert Florian , Goerke Sebastian M. , Pfeifer Dietmar , Finkenzeller Günter , Stark Gerhard B. , Simunovic Filip
Published: December 2016

Vascularization is essential for bone development, fracture healing, and bone tissue engineering. We have previously described that coculture of primary human osteoblasts (hOBs) and human umbilical vein endothelial cells (HUVECs) improves differentiation of both cell types. Investigating the role of microRNAs (miRNAs) in this system, we found that miR‐126 is highly upregulated in hOBs following coculturing with HUVECs. In this study we performed miR‐126 gain‐of‐function and loss‐of‐function experiments in hOBs followed by microarray analysis in order to identify targets of miR‐126. The transcript cluster IDs were sieved by applying cut‐off criteria and by selecting transcripts which were upregulated following miR‐126 downregulation and vice versa. The calmodulin regulated spectrin associated protein 1 (CAMSAP1) mRNA was confirmed to be differentially regulated by miR‐126. Using the luciferase reporter assay it was demonstrated that CAMSAP1 is directly targeted by miR‐126. In this study, we show that miR‐126 and CAMSAP1 directly interact in hOBs. This finding has potential implications for tissue engineering applications. J. Cell. Biochem. 118: 1756–1763, 2017. © 2016 Wiley Periodicals, Inc.
Decomposing and Clique‐Coloring (Diamond, Odd‐Hole)‐Free Graphs
Authors: Chudnovsky Maria , Lo Irene
Published: December 2016

A diamond is a graph on vertices with exactly one pair of nonadjacent vertices, and an odd hole is an induced cycle of odd length greater than 3. If G and H are graphs, G is H‐free if no induced subgraph of G is isomorphic to H. A clique‐coloring of G is an assignment of colors to the vertices of G such that no inclusion‐wise maximal clique of size at least 2 is monochromatic. We show that every (diamond, odd‐hole)‐free graph is 3‐clique‐colorable, answering a question of Bacsó et al. (SIAM J Discrete Math 17(3) (2004), 361–376).
Novel porcine model of implant‐associated osteomyelitis: A comprehensive analysis of local, regional, and systemic response
Authors: Jensen Louise Kruse , Koch Janne , Dich‐Jorgensen Kirstine , Aalbæk Bent , Petersen Andreas , Fuursted Kurt , Bjarnsholt Thomas , Kragh Kasper Nørskov , Tøtterup Mikkel , Bue Mats , Hanberg Pelle , Søballe Kjeld , Heegaard Peter M.H. , Jensen Henrik Elvang
Published: December 2016

Pigs are favorable experimental animals for infectious diseases in humans. However, implant‐associated osteomyelitis (IAO) models in pigs have only been evaluated using high‐inoculum infection (>108 CFU) models in 1975 and 1993. Therefore, the aim of this paper was to present a new low inoculum porcine model of human IAO based on 42 experimental pigs. The model was created by drilling an implant cavity in the tibial bone followed by insertion of a small steel implant and simultaneous inoculation of Staphylococcus aureus bacteria (n = 32) or saline (n = 10). The infected pigs were either inoculated with 104 CFU (n = 26) or 102 and 103 CFU (n = 6). All animals were euthanized 5 days after insertion of implants. Pigs receiving the high‐inoculum infections showed a significantly higher volume of bone lesion, number of neutrophils around the implant, concentrations of acute phase proteins in serum, and enlargement of regional lymph nodes. A positive correlation was present between a high number of surrounding neutrophils and high values of all other parameters. Furthermore, a threshold of 40 neutrophils per 10 high power fields for the histopathological diagnosis of high grade IAO was defined. In conclusion: This paper describes a novel low‐inoculum S. aureus porcine model of IAO which was demonstrated to be reliable, reproducible and discriminative to human IAO, and represents a requested and valuable tool in orthopedic research. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2211–2221, 2017.
Fatty acids from grain fed and grass fed beef in South Africa
Authors: Hall N. , Schönfeldt H. C. , Pretorius B.
Published: December 2016

Regular consumption of red meat is often considered detrimental to human health due, among other factors, to a perceived unhealthy fatty acid profile. With production systems intensifying globally, grain‐fed beef from feedlots are dominating market shelves within westernized countries. Although grass fed beef is considered to be a healthier alternative due to a lower total fat content and more desirable fatty acid composition, no studies have been performed to quantify such differences in South Africa.

The current study evaluated the fatty acid profile of the different beef offerings available on the market, and expressed the data per edible portion to effectively guide future dietary recommendations. Notable differences were found in the quantity and quality of different fatty acids between the different production systems. Due to the unique classification system dictating the characteristics of fresh meat the result indicated distinctive differences between South African red meat and international produce.
Tropical cyclone tracking and verification techniques for Met Office numerical weather prediction models
Authors: Heming J. T.
Published: December 2016

The Met Office has been objectively verifying tropical cyclone (TC) forecast tracks from its global numerical weather prediction model for many years and also produces TC forecast guidance in real time from both the deterministic and ensemble configurations of the model. An essential component of these processes is a system to automatically identify TCs in the model analysis and track them in the model forecast. This paper describes the history of TC tracking in Met Office models and gives details of the current technique used both within the TC forecast verification system and in the production of real‐time forecast guidance products.
Microbial and endogenous metabolic conversions of rye phytochemicals
Authors: Koistinen Ville M. , Hanhineva Kati
Published: December 2016

Rye is one of the main cereals produced and consumed in the hemiboreal climate region. Due to its use primarily as wholegrain products, rye provides a rich source of dietary fibre as well as several classes of phytochemicals, bioactive compounds with potentially positive health implications. Here, we review the current knowledge of the metabolic pathways of phytochemical classes abundant in rye, starting from the microbial transformations occurring during the sourdough process and colonic fermentation and continuing with the endogenous metabolism. Additionally, we discuss the detection of specific metabolites by MS in different phases of their journey from the cereal to the target organs and excretion.
Qualitatively understanding patients' and health professionals' experiences of the BRECONDA breast reconstruction decision aid
Authors: Sherman Kerry A. , Shaw Laura‐Kate , Jørgensen Lone , Harcourt Diana , Cameron Linda , Boyages John , Elder Elisabeth , Kirk Judy , Tucker Katherine
Published: December 2016

Objective

Women diagnosed with breast cancer or ductal carcinoma in situ and those with a genetic susceptibility to developing this disease face the challenging decision of whether or not to undergo breast reconstruction following mastectomy. As part of a large randomized controlled trial, this qualitative study examined women's experiences of using the Breast RECONstruction Decision Aid (BRECONDA) and health professionals' feedback regarding the impact of this resource on patients' knowledge and decision making about breast reconstruction.

Method

Semistructured interviews were conducted with women who accessed the BRECONDA intervention (N = 36) and with their healthcare providers (N = 6). All interviews were transcribed verbatim and subjected to thematic analysis by 3 independent coders.

Results

Participants reported an overall positive impression, with all interviewees endorsing this decision aid as a useful resource for women considering reconstructive surgery. Thematic analysis of patient interviews revealed 4 themes: overall impressions and aesthetics; personal relevance and utility; introducing BRECONDA; and advantages and suggested improvements. Analysis of health professionals' interviews also revealed 4 themes: need for BRECONDA, impact of BRECONDA, potential difficulties that may arise in using the decision aid, and recommending BRECONDA to patients. Patients indicated that they derived benefit from this resource at all stages of their decision‐making process, with the greatest perceived benefit being for those early in their breast reconstruction journey.

Conclusion

These findings support the use of BRECONDA as an adjunct to clinical consultation and other information sources.
Reduction of contact resistance in V‐based electrode for high AlN molar fraction n‐type AlGaN by using thin SiNx intermediate layer
Authors: Nagata Noriaki , Senga Takashi , Iwaya Motoaki , Takeuchi Tetsuya , Kamiyama Satoshi , Akasaki Isamu
Published: December 2016

We found out the reduction of contact resistance in V‐based electrode for high AlN molar fraction n‐type AlGaN by using thin SiNx intermediate layer. The contact resistivity for n‐type Al0.70Ga0.30N with the V/Al/Ni/Au electrode using SiNx intermediated layer reached 1.13 × 10−6 Ω cm2. Moreover, contact resistivity using SiNx intermediated layer had been reduced more than one order of magnitude in all AlN molar fractions from 0.62 to 0.87. Using this electrode, we also demonstrated UV light‐emitting diodes (LEDs) on n‐type Al0.70Ga0.30N underlying layer with an emission wavelength of approximately 283 nm. An operating LED voltage using a V/Al/Ni/Au electrode with SiNx intermediated layer was 3.3 V lower at 100 mA current injection than that without SiNx intermediated layer.
Partial crystallization in amorphous magnetic film induced by Ru layer interface
Authors: Shi J. Z. , Yang Y. , Tan H. K. , Piramanayagam S. N. , Lim C. B. , Seet H. L. , Ho S. L. , Hu J. F.
Published: December 2016

Partial crystallization in amorphous magnetic film is observed in this study. The film of Co46Fe46Zr5B3/Ru/Co46Fe46Zr5B3 (CFZB/Ru/CFZB) was prepared on glass substrate by DC magnetron sputtering. The CFZB underlayer (CFZB‐UL) and the CFZB overlayer (CFZB‐OL) were deposited under nominally same sputtering conditions, i.e. target, working gas, working pressure, input power, and deposition duration. The transmission electron microscopy (TEM) images with fast Fourier transform (FFT) patterns revealed that the CFZB‐UL was amorphous while the CFZB‐OL became unexpectedly partially crystallized. The result of X‐ray diffraction (XRD) spectra verified the TEM observation. The cause of the partial crystallization is attributed to the lower concentration of glass formers and the lattice matching between the overlayer and the Ru layer below.