bluuebunny/crossref_metadata_2025 huggingface dataset:
An open label, randomized phase 2 trial assessing the impact of food on the tolerability of abemaciclib in patients with advanced breast cancer
Authors: Lim Elgene , Boyle Frances , Okera Meena , Loi Sherene , Goksu Sema Sezgin , van Hal Gertjan , Chapman Sonya C. , Gable Jonathon Colby , Chen Yanyun , Price Gregory L. , Hossain Anwar M. , Gainford M. Corona , Ezquerra Meritxell Bellet
Published: August 2022

Purpose

Abemaciclib, a CDK4 & 6 inhibitor, is indicated for advanced breast cancer treatment. Diarrhea is a frequently associated adverse event of abemaciclib. The study objective was to investigate if food intake impacts local gastrointestinal toxicity.

Methods

This Phase 2 study (I3Y-MC-JPCP, NCT03703466) randomized 72 patients 1:1:1 to receive abemaciclib 200 mg monotherapy twice daily (1) with a meal, (2) in a modified fasting state or (3) without regard to food. Primary endpoints included: incidence of investigator assessed severe (≥ Grade 3), prolonged (> 7 days) Grade 2 diarrhea, treatment discontinuation, dose modifications, and loperamide utilization during the first 3 cycles of treatment. Patient outcomes were captured via a daily electronic diary. Pharmacokinetics (PK) are reported.

Results

Incidence of investigator assessed severe diarrhea (Grade ≥ 3) was 1.4% (1 patient in Arm 1). Median duration of Grade 3 diarrhea was 1 day by both investigator assessment (1 patient in Arm 1) and patient-reported assessment (1 patient each in Arms 1 and 3). Median duration of investigator-assessed Grade 2 diarrhea was 2 days overall. No patient discontinued treatment due to diarrhea. Nine patients (12.7%) had a dose reduction, and 7 patients (9.9%) had a dose omission due to diarrhea. Ninety-four percent of patients used loperamide at least once. Abemaciclib PK was comparable across the 3 arms.

Conclusion

The results suggest that diarrhea incidence associated with abemaciclib was unrelated to timing of food intake, was predominantly low grade, of short duration and well managed with loperamide and dose modifications.
Educate to transform: An innovative experience for faculty training
Authors: Sanz Noemy Martín , Urías María Dolores Vivas , Salgado Leire Nuere , Benítez Noelia Valle , Martínez María Consuelo Valbuena
Published: August 2022

Learning-focussed educational models require the development of pedagogical, methodological, assessment and technological competences among the faculty community. The COVID-19 pandemic has accentuated the need for this training. This study evaluates the impact of the training project “Educate to Transform” on teacher attitudes, knowledge and on the implementation of innovative teaching methodologies. There were 695 faculty participants in the program conducted at the Universidad Francisco de Vitoria (UFV). Participants included full-time professors (FULL-PROF) and part-time professors (PART-PROF). The measurement instrument was validated using the entire sample and a subsample of 357 participants was used to analyse the impact of the program (pre and post measurement). Professor attitudes and knowledge of or familiarity with innovative methodologies and their application in the classroom were evaluated. The findings show that the program improved the attitudes of teachers towards innovation, raised the level of awareness and number of methodologies implemented in the classroom. The methodology towards more experiential and collaborative learning is effective in transforming teaching practice. Furthermore, the implementation of the program through the CANVAS platform, making teachers live the experience as learners, seems to have contributed to improve the teachers' attitude towards the LMS. The only difference found among the participants was a worse attitude towards innovation on the part of medical teachers, with a clearly differentiated profile of teachers and students, as well as a greater implementation of active methodologies by teachers with a lower teaching load. Overall, it may be concluded that the program achieved its proposed objectives.
Shallow katabatic flow on a non-uniformly cooled slope
Authors: Hewitt Richard , Unadkat Jay , Wise Anthony
Published: August 2022

We examine katabatic flow driven by a non-uniformly cooled slope surface but unaffected by Coriolis acceleration. A general formulation is given, valid for non-uniform surface buoyancy distributions over a down-slope length scale $$L\gg \delta _0$$

L
≫

δ
0

, where $$\delta _0=\nu /(N\sin \alpha )^{1/2}$$

δ
0

=
ν
/

(
N
sin
α
)

1
/
2

is the slope-normal Prandtl depth, for a kinematic viscosity $$\nu$$
ν
, buoyancy frequency N and slope angle $$\alpha$$
α
. We demonstrate that the similarity solution of Shapiro and Fedorovich (J Fluid Mech 571:149–175, 2007) can remain quantitatively relevant local to the end of a non-uniformly cooled region. The usefulness of the steady similarity solution is determined by a spatial eigenvalue problem on the L length scale. Broadly speaking, there are also two modes of temporal instability; stationary down-slope aligned vortices and down-slope propagating waves. By considering the limiting inviscid stability problem, we show that the origin of the vortex mode is spatial oscillation of the buoyancy profile normal to the slope. This leads to vortex growth in a region displaced from the slope surface, at a point of buoyancy inflection, just as the propagating modes owe their existence to an inflectional velocity. Non-uniform katabatic flows that detrain fluid to the ambient are shown to further destabilise the vortex mode whereas entraining flows lead to weaker vortex growth rates. Rayleigh waves dominate in general, but the vortex modes become more significant at small slope angles and we quantify their relative growth rates.
Effects of human-induced water level fluctuations on copepod assemblages of the littoral zone of Lake Maggiore
Authors: Cifoni Marco , Boggero Angela , Rogora Michela , Ciampittiello Marzia , Martínez Alejandro , Galassi Diana Maria Paola , Fiasca Barbara , Di Lorenzo Tiziana
Published: August 2022

Human-induced water level fluctuations (WLFs) are among the major pressures threatening lake ecosystems. Their effect on meiobenthic species of the littoral zone has been poorly investigated. In this study, we aimed at assessing the effects of human-induced WLFs on the composition and functionality of the benthic copepod assemblages of the littoral zone of Lake Maggiore, Italy and Switzerland. From 1942 to present, the water level of Lake Maggiore has been regulated through the Miorina Dam. We monitored copepod assemblages during different water levels defined within the period of regulation by the dam, using taxonomy- and trait-based metrics. We observed variation in the overall abundance and biomass of copepods, as well as in the number of individuals belonging to some trait classes such as ovigerous females, opportunists, omnivores and deposit feeders. None of the investigated trait class was completely lost. The results of our study suggest that ecosystem services supplied by the littoral zone of Lake Maggiore are likely altered by human-induced WLFs. Our findings provide a first picture of WLF impacts on benthic copepod assemblages, which can be useful for future research expanding on other functional traits.
Money in one click: Inequalities in digital financial practices and digital Skills among emerging adults in Switzerland
Authors: Baudat Sophie , Henchoz Caroline
Published: August 2022

Although Internet is becoming a medium for all economic activities, inequalities in digital financial practices among youth have received little attention. Using a sample of emerging adults in Switzerland (18–29 years, N = 385), the latent class analysis used in this study offers a unique opportunity to identify different configurations of digital economic practices considering that online money consumption, management, and production are closely related. The analysis reveals four classes of digital economic practices that reflect different user profiles: Regular Consumers (60.5%), Occasional Consumers (20.8%), Moderate Managers (15.1%), and Active Users (3.6%). Class membership is associated with some of the sociodemographic characteristics as well as digital skills of emerging adults. Our findings suggest that prevention and financial education programs should be adapted to the different user profiles and focus more specifically on occasional digital financial users who come from less privileged backgrounds and have the fewest digital skills.
CVEM-BEM Coupling with Decoupled Orders for 2D Exterior Poisson Problems
Authors: Desiderio Luca , Falletta Silvia , Ferrari Matteo , Scuderi Letizia
Published: August 2022

For the solution of 2D exterior Dirichlet Poisson problems, we propose the coupling of a Curved Virtual Element Method (CVEM) with a Boundary Element Method (BEM), by using decoupled approximation orders. We provide optimal convergence error estimates, in the energy and in the weaker $$\textit{L}^\text {2}$$

L
2

-norm, in which the CVEM and BEM contributions to the error are separated. This allows for taking advantage of the high order flexibility of the CVEM to retrieve an accurate discrete solution by using a low order BEM. The numerical results confirm the a priori estimates and show the effectiveness of the proposed approach.
An overview of computational tools for preparing, constructing and using resistance surfaces in connectivity research
Authors: Dutta Trishna , Sharma Sandeep , Meyer Ninon F. V. , Larroque Jeremy , Balkenhol Niko
Published: August 2022

Context

Connectivity between habitat patches is a recognized conservation action to conserve biodiversity in a rapidly changing world. Resistance surfaces, a spatial representation of cost of movement across the landscape, are often the foundation for connectivity analyses but working with them can be daunting due to the diversity and complexity of software tools.

Objectives

We present an overview of the steps involved when working with resistance surfaces, identify tools that perform specific tasks, evaluate user experience with the tools, identify needs of the user community, and present some recommendations for users and developers.

Methods

We identified tools applicable at each of the three steps (i) preparing data, (ii) constructing and optimizing surfaces, and (iii) using resistance surfaces. We conducted an online survey of the connectivity user community to assess the popularity and experience with tools on five criteria and identified characteristics important in the selection of connectivity tools.

Results

We reviewed a total of 43 tools, of which 10 are useful for data preparation, 27 allow construction, and 30 tools that use resistance surfaces. A total of 148 survey participants working in 40 countries were familiar with 37 tools. Tools are ranked heterogeneously for the five criteria. Crucial avenues for future development of connectivity tools identified by respondents are incorporation of uncertainties, dynamic connectivity modelling, and automated parameter optimization.

Conclusions

Since resistance surfaces are used for a variety of applications, it is important that users are aware about the appropriate tools. We anticipate that future tools for connectivity research will incorporate more complex and biologically more realistic analytical approaches.
Vegetation indices as a Tool for Mapping Sugarcane Management Zones
Authors: de Oliveira Maia Felipe Cardoso , Bufon Vinícius Bof , Leão Tairone Paiva
Published: August 2022

In precision agriculture, the adoption of management zones (MZs) is one of the most effective strategies for increasing agricultural efficiency. Currently, MZs in sugarcane production areas are classified based on conventional soil sampling, which demands a lot of time, labor and financial resources. Remote sensing (RS) combined with vegetation indices (VIs) is a promising alternative to support the traditional classification method, especially because it does not require physical access to the areas of interest, is cost-effective and less labor-intensive, and allows fast and easy coverage of large areas. The objective of this study was to evaluate the ability of the normalized difference vegetation index (NDVI) and the two-band enhanced vegetation index (EVI2) to classify sugarcane MZs, compared with the conventional method, in the Brazilian Cerrado biome (savannah), where about half of Brazil´s sugarcane production takes place. This study used historical crop production data from 5,500 production fields in three agricultural years (2015 to 2018) and NDVI and EVI2 values of 14 images acquired by the Landsat 8 satellite from 2015 to 2018 in Google Earth Engine (GEE). Although improvements are still necessary and encouraged, a new methodology of classifying MZs according to VIs was proposed in this study. The NDVI was not correlated with MZs classified using the conventional method, whereas EVI2 was more sensitive to biomass variations between MZs and, therefore, could better discriminate between MZs. The EVI2 values measured in crops aged 180 to 240 days in the rainy season proved to be the best strategy for classifying MZs by RS, where MZ A, for example, had EVI2 of 0.37, compared to MZ E, which had an EVI2 of 0.32.
Agency as conversion process
Authors: Bazzani Giacomo
Published: August 2022

Its importance for understanding social dynamics notwithstanding, the concept of agency is one of sociology’s more controversial ideas. The debate around this concept has mostly been developed at a theoretical level and the empirical studies tend to rely on socio-psychological interpretations of agency as a stable, inner force capable of influencing prospects, decisions, and behavior with little room for change in agency capacity. Social sciences, though, should take a more dynamic stance on agency and highlight the role of the different elements of the social context that can enable or hinder individual agency capacity. Prompted by recent developments of the Capability Approach, this article proposes a framework for the study of agency that defines individual agency as the result of a conversion process of personal resources shaped by conversion factors. Conversion factors operate at micro, meso, and macro levels of analysis, each of which can be oriented toward past experiences, present conditions, and future prospects. This article also seeks to analytically distinguish three types of agency outcome: adaptation, autonomy, and influence. Such a framework will facilitate the transformation of the slippery notion of agency into more tractable empirical phenomena which increase its analytical and critical capacity.
How Hybrid Organizations Respond to Institutional Complexity: The Case of Norway
Authors: Sætre Hilde Svrljuga
Published: August 2022

In past decades, hybrid organizations and institutional complexity have received growing attention, yet questions remain about how hybrids manage institutional complexity in the Nordic welfare states. This article investigates how Norwegian social enterprises (SEs), a subset of hybrid organizations, internally manage contradictory demands when externally engaging with multiple logics. The data consists of interviews of leaders and staff members from five SEs, and the findings show that most institutional referents hold a public-sector logic which may crowd out the hybrid nature of SEs. Depending on the conflicting demands, SEs mix decoupling and selective coupling when responding to them. Some were also found to rely on the structural responses of organizational compartmentalization. Compared to the blended hybrids, the structural hybrids experience less internal tension when managing institutional complexity since logic compartmentalization allows the organizations to attend both to their in-use logic and at-play demands. The data yield compelling insights into how the Nordic welfare state may incite a specific configuration of SE where logic compartmentalization appears as a pragmatic choice.
Long-Term Dynamics of Voluntary Engagement: Differentiating Social Structural from Cohort and Period Effects
Authors: Jacobsen Jannes , Schieferdecker David , Gerstorf Denis , Hutter Swen , Specht Jule
Published: August 2022

Prior research has suggested three explanations why levels of voluntary engagement rise and fall over time within societies. A social structural explanation considers individual resources crucial for engagement and argues that a redistribution of those resources may bring about changes in engagement. A cohort-based explanation considers socialisation and experiences in formative years as crucial for the uptake of engagement. Finally, a period-based explanation considers extraordinary events, external shocks, and crises to be crucial for engagement. So far, these explanations have mainly been tested separately and little is known about the relative strength of each of the proposed factors. Using data from a large German household panel survey that assessed engagement almost annually across four decades, we found that most social structural factors (e.g., education, employment, income) maintained their predictive effects for engagement, irrespective of cohort or period. The only notable exception was that the gender gap observed has narrowed substantially across periods and cohorts. Moreover, cohort effects were rendered almost negligible once we factored in periods. Taken together, our results suggest that individual characteristics and extraordinary events are the main factors influencing voluntary engagement rather than shared societal experiences of cohorts.
Storability of Irish Potato (Solanum tuberosum L.) Varieties Grown in Kenya, Under Different Storage Conditions
Authors: Gikundi Evelyne N. , Buzera Ariel K. , Orina Irene N. , Sila Daniel N.
Published: August 2022

Long-term use of fresh potatoes is constrained due to post-harvest losses and limited or poor storage systems. Loss of potato quality during storage is mostly due to weight loss, excessive sprouting, decaying, greening, pest attack and changes in sugar content which is a major concern for processors. The storability of three potato varieties namely Shangi, Unica, and Dutch Robijn was evaluated under four storage conditions: (1) room temperature (RT) (21.7 ± 5 °C) and ambient relative humidity (RH) (73.5 ± 6.7%); (2) 10 °C/75% RH; (3) 10 °C/ambient RH and (4) 7 °C/75% RH for 3 months. Parameters analysed included weight loss, sprouting, greening, rotting incidence and changes in simple sugars (sucrose, glucose and fructose) content. Shangi variety had the poorest storability having exhibited the highest weight loss, sprouting, greening and rotting rates among the varieties and in all storage conditions. In all the varieties, weight loss was highest at room temperature/RH (6.9–35.13%) and lowest at 7 °C/75% RH (1.6–3.7%). Sprouting rate was highest at RT/RH (100%) and lowest at 7 °C/75% RH (2.0–45.2%). Greening incidence was highest at RT/RH (10.3–24.0%) and lowest at 7 °C/75% RH (2.0–16.1%). The tubers accumulated simple sugars during storage with the highest relative accumulation recorded at 7 °C/75% RH. Total reducing sugars increased by 3.8–9.3-fold at RT/RH to 26.0–68.5-fold at 7 °C/75% RH. Low-temperature storage minimized the rate of physical tuber deterioration with 7 °C/75% RH best preserving the potatoes’ physical properties while it led to the highest accumulation of simple sugars.
Decadal Surface Changes and Displacements in Switzerland
Authors: Bickel Valentin Tertius , Manconi Andrea
Published: August 2022

Multi-temporal, high-resolution, and homogeneous geospatial datasets acquired by space- and/or airborne sensors provide unprecedented opportunities for the characterization and monitoring of surface changes on very large spatial scales. Here, we demonstrate how an off-the-shelf, open-source image correlation algorithm can be combined with SwissALTI3D LiDAR-derived elevation data from different tracking periods to create country-scale surface displacement and vertical change maps of Switzerland, including Liechtenstein, with minimal computational effort. The results show that glacier displacement and ablation make up the most significant fraction of the detected surface changes in the last two decades. In addition, we identify numerous landslides and other geomorphic features, as well as manmade changes such as construction sites and landfills. All produced maps and data products are available online, free of charge.
Nitrogen-doped, proton-exchanged Dion-Jacobson layered niobate perovskites for photocatalytic hydrogen generation in solar light
Authors: Kulischow Natalia , Ade Mirco , Weiss Morten , Marschall Roland
Published: August 2022

Wide band gap semiconductor niobate photocatalysts with Dion-Jacobson layered perovskite structure were nitrogen-doped via simple gas–solid reaction to extend their absorption into the visible light range. Nitrogen doping was performed using ammonia as precursor, resulting in decreased band gaps of doped AB2Nb3O10 compounds (A = Cs, Rb, K; B = Ca, Sr) down to 2.5 eV. The resulting materials were investigated concerning their chemical and electronic structures. Nitrogen-doped AB2Nb3O10 crystals showed a clear red shift in absorption. Photocatalytic performance tests for the doped materials evaluated the capability of H2 production under simulated solar irradiation. The addition of carbonates to the gas–solid reaction turned out to be advantageous for the reduction of defects and the preservation of photocatalytic activity of nitrogen-doped layered niobates AB2Nb3O10.

Graphical Abstract
Constraining active-sterile neutrino mixing via lepton flavor violating decays of mesons
Authors: Hu Shiyong , Wong Sam Ming-Yin , Xu Fanrong
Published: August 2022

As a hypothetic particle, a sterile neutrino can exist in types of new physics models. In this work by investigating flavor violating semileptonic and leptonic decays of K,D, and B mesons induced by the GeV scale sterile neutrino, we explore its allowed regions in parameter space. Analytically, we derive branching fractions of semileptonic decay $M^{+}_{h}\to M_{l}^{+}\ell _{1}^{+}\ell _{2}^{-}$

M

h

+

→

M

l

+

ℓ

1

+

ℓ

2

−

and leptonic decay $M^{0}\to \ell _{1}^{-}\ell _{2}^{+}$

M

0

→

ℓ

1

−

ℓ

2

+

, including the contribution from a new box diagram contribution due to the massive sterile neutrino. Imposing its mass ranges, we numerically analyze the active-sterile neutrino mixings in corresponding regions. We find that when the sterile neutrino mass is located in between pion and kaon mass, K+→π+e±μ∓ gives the strongest constraint while B+→π+e±μ∓ provides the dominated constraint when its mass in between of kaon and B meson. If the sterile neutrino is even heavier than Bmesons, the LHCb $B^{0}_{s}\to \mu ^{\pm } e^{\mp }$

B

s

0

→

μ

±

e

∓

results gives the strongest constraint.
Knowledge, attitudes, and practices towards COVID-19 among undergraduates during emergency remote learning
Authors: Tan Chin Xuan , Wong Shu Chyi , Tan Seok Shin , Tan Seok Tyug
Published: August 2022

Background

The coronavirus disease 2019 (COVID-19) pandemic paralyzes the education sector. To minimize the interruption of teaching and learning, most universities in Malaysia shifted to virtual mode during this unprecedented period of the pandemic. With an ever-increasing number of Malaysians fully vaccinated against COVID-19, the education system is expected to switch back to face-to-face mode this year. It is crucial to assess the knowledge, attitudes, and practices (KAP) of COVID-19 among emergency remote learning undergraduates before reverting to physical teaching and learning. Hence, a study was conducted with this aim in mind.

Methods

A total of 299 Malaysian undergraduates were recruited through a snowball sampling approach. The online questionnaire encompassed three main segments: informed consent, sociodemographic information, and KAP questions on COVID-19.

Results

The mean scores for knowledge, attitude, and practice were 4.05/6, 11.14/12, and 5.07/7, respectively. The results of the present study showed that year 1 respondents had significantly higher levels (p < 0.05) of KAP scores than year 4 respondents. In addition, the attitude score of science majors respondents was significantly greater (p < 0.05) than those of nonscience majors. The KAP scores showed no significant difference among groups with different sexes, ethnicities, and COVID-19 histories. Partial correlation analysis revealed that the overall knowledge score was positively correlated with attitude (r = 0.193, p = 0.001) and practice (r = 0.343, p < 0.001) scores whereas the total attitude score was positively correlated with the total practice score (r = 0.149, p = 0.010).

Conclusion

Our current results suggest that COVID-19 workshops, seminars, or training programs for year 4 students could be conducted to enhance their KAP levels.
Feasibility, Acceptability, and Barriers to Implementing Select Non-Pharmaceutical Interventions to Reduce the Transmission of Pandemic Influenza - United States, 2019
Authors: Ahmed Faruque , Qualls Noreen , Kowalczyk Shelly , Randolph Cunningham Suzanne , Zviedrite Nicole , Uzicanin Amra
Published: August 2022

Objectives:

This study aimed to assess the feasibility and acceptability of implementing non-pharmaceutical interventions (NPIs) reserved for influenza pandemics (voluntary home quarantine, use of face masks by ill persons, childcare facility closures, school closures, and social distancing at schools, workplaces, and mass gatherings).

Methods:

Public health officials in all 50 states (including Washington, DC) and 8 territories, and a random sample of 822 local health departments (LHDs), were surveyed in 2019.

Results:

The response rates for the states/ territories and LHDs were 75% (44/ 59) and 25% (206/ 822), respectively. Most of the state/ territorial respondents stated that the feasibility and acceptability of implementing NPIs were high, except for K-12 school closures lasting up to 6 weeks or 6 months. The LHD respondents also indicated that feasibility and acceptability were lowest for prolonged school closures. Compared to LHD respondents in suburban or urban areas, those in rural areas expressed lower feasibility and acceptability. Barriers to implementing NPIs included financial impact, compliance and difficulty in enforcement, perceived level of disease threat, and concerns regarding political implications.

Conclusion:

Proactive strategies to systematically address perceived barriers and promote disease prevention ahead of a new pandemic are needed to increase receptivity and consistent adoption of NPIs and other evidence-based countermeasures.
On Dialogical Writing, Self-forming, and Salon Culture: Rahel Varnhagen, Henriette Herz, and Fanny Lewald
Authors: Wagner Ulrike
Published: August 2022

Salons evoke high-flown associations; we picture elegant people gathering in glamorous settings for cultivated conversations about the arts, literature, and politics. The so-called salons hosted around 1800 in Berlin by bourgeois Jewish women are tied to promises of emancipation and religious toleration. Scholars have either hailed the empowering functions of these convivial gatherings or debunked their enlightened promises as myths. Drawing on the latest research on conviviality in the social sciences, on Friedrich Schleiermacher's theory of sociability, and on writings by and about Rahel Varnhagen, Henriette Herz and Fanny Lewald, this essay approaches the topic of the salon from a different angle. I argue that these women's social endeavours were not tied to specific ends that we can either admiringly endorse or expose as failures from today's perspective. The notions of the female self, of writing, and the conceptions of literature and philosophy emerging from these convivial constellations are inherently dialogical and shifting. Conversations may sometimes break open hierarchies, but they may also foster conflict and no improvement. The value of these encounters, I suggest, lies in the effort made rather than a classifiable outcome.
Central-line–associated bloodstream infections in a pediatric oncology and hematology hospital at home program
Authors: Raimbault Sylvain C. , Domenech Carine , Fuhrmann Christine , Bertrand Amandine
Published: August 2022

Objective:

Central-line–associated bloodstream infections (CLABSIs) are associated with significant morbidity among pediatric oncology-hematology patients, and risk factors remain largely unknown in the setting of hospital at home (HAH). Children in HAH receive intensive treatment (eg, chemotherapy and parenteral nutrition), with frequent central-line handling; thus, they may be at higher risk for CLABSI.

Methods:

We conducted a monocentric retrospective study of patients with a central line included in our HAH program from January 1 to December 31, 2016. HAH patient characteristics for children developing CLABSIs were compared to those who did not, based on blood cultures positive for infection and clinical data of all patients included.

Results:

Overall, 492 HAH stays were analyzed, with 144 patients. The overall CLABSI rate in these patients was 2.6 per 1,000 central-line days. Children who developed CLABSIs were younger (median age, 2.5 vs 8.8 years; P < .001), suffered more from hematological pathologies (malignant or nonmalignant, 75% vs 52%; P = .02), and had more frequently undergone hematopoietic stem-cell transplantation (30.8% vs 6.5%; P = .01). In addition, these patients often had a tunneled externalized catheter as the central line and were more frequently given parenteral nutrition at home (46% vs 8%; P < .001).

Conclusions:

CLABSI rates for children in HAH were more similar to those of inpatients than to rates previously reported for ambulatory patients. The factors associated with infection identified herein should be further validated in multicentric studies and considered to improve HAH practices, parallel to prevention measures used in the inpatient setting.
Large-eddy simulation of gusty wind turbulence over a travelling wave
Authors: Hao Xuanting , Shen Lian
Published: August 2022

Wind gustiness in the marine atmospheric boundary layer affects significantly the dynamics of air–sea interaction. To understand the impacts of wind gust events, we perform large-eddy simulation of wind turbulence over a travelling wave to investigate the response of the wind field to an impulsive wind speed increase or decrease. It is found that the turbulence fluctuations and the terms in the turbulent kinetic energy budget equation have a delayed response to the change in the mean flow, while the response of the wave-coherent motions is quasi-stationary. The wave-coherent motions are investigated quantitatively through comparison with a viscous curvilinear model developed by Cao et al. (J. Fluid Mech., vol. 901, 2020, A27) and Cao & Shen (J. Fluid Mech., vol. 919, 2021, A38). We observe an asymmetric hysteresis between the growing wind and the decaying wind in the evolution of the form drag and the viscous drag. We find further that the variation of the wave growth rate during the wind gust is related closely to the contribution from the out-of-phase component of the vertical velocity. Our discoveries provide evidence for the necessity of improving non-equilibrium turbulence and wind input modelling to account for the wind gustiness effect in future studies.
Associations of dietary intakes of calcium, magnesium and soy isoflavones with osteoporotic fracture risk in postmenopausal women: a prospective study
Authors: Cui Yong , Cai Hui , Gao Yutang , Dai Qi , Yang Gong , Zheng Wei , Shu Xiao-Ou
Published: August 2022

The role of dietary factors in osteoporotic fractures (OFs) in women is not fully elucidated. We investigated the associations between incidence of OF and dietary calcium, magnesium and soy isoflavone intake in a longitudinal study of 48 584 postmenopausal women. Multivariable Cox regression was applied to derive hazard ratios (HRs) and 95 % confidence intervals (CIs) to evaluate associations between dietary intake, based on the averages of two assessments that took place with a median interval of 2⋅4 years, and fracture risk. The average age of study participants is 61⋅4 years (range 43⋅3–76⋅7 years) at study entry. During a median follow-up of 10⋅1 years, 4⋅3 % participants experienced OF. Compared with daily calcium intake ≤400 mg/d, higher calcium intake (>400 mg/d) was significantly associated with about a 40–50 % reduction of OF risk among women with a calcium/magnesium (Ca/Mg) intake ratio ≥1⋅7. Among women with prior fracture history, high soy isoflavone intake was associated with reduced OF risk; the HR was 0⋅72 (95 % CI 0⋅55, 0⋅93) for the highest (>42⋅0 mg/d) v. lowest (<18⋅7 mg/d) quartile intake. This inverse association was more evident among recently menopausal women (<10 years). No significant association between magnesium intake and OF risk was observed. Our findings provide novel information suggesting that the association of OF risk with dietary calcium intake was modified by Ca/Mg ratio, and soy isoflavone intake was modified by history of fractures and time since menopause. Our findings, if confirmed, can help to guide further dietary intervention strategies for OF prevention.
Working-Class Leaders and Their Political Work Between Civil-Societal Engagement and Class Conflicts: The Case of August Bebel – A Comment to John D. French
Authors: Schmidt Jürgen
Published: August 2022

John D. French's stimulating article, which explores the scope for comparing working-class leaders across time and space, is considered in this contribution by reference to my biography of August Bebel and with a particular focus on the following topics: a) historical actors as shaped by their own particular time and place; b) the importance of personal relationships and networks in making people who they are; c) the importance of psychological elements and the risk in interpreting them in retrospect – recovering them depends upon the sources available; d) how charisma reflects an interdependence between attribution and individual qualities; e) the importance of political milieux for the flourishing of individual working-class leaders; and f) the relationship between political work to both civil society and existing class relations. Using these approaches allows us to write cross-border and cross-temporal “embodied social biographies”, as suggested by French.
‘To Satisfy My Savage Appetite’: Slavery, Belief, and Sexual Violence on the Mina (Gold) Coast, 1471–1571
Authors: Konadu Kwasi
Published: August 2022

Scholars of women and girls in African history, focusing on gender and power within religious or colonial (slavery) contexts, have drawn our attention to sexual violence against girls and women. Despite what historians of slavery and imperial violence have noted about their vulnerability and survival strategies in ‘colonial’ and ‘postcolonial’ contexts, questions remain about sexual predation and slavery in earlier periods. In the Mina (Gold) Coast, there is little known about the lived experiences of enslaved and ‘freed’ girls and women in the sixteenth century, and this is especially true for females held captive or in proximity to Portuguese slaving and gold trading bases of operation. Although only three inquisitional trials exist, sources which provide rare African female voices in the Portuguese colonial and evangelical world, their unprecedented baseline evidence for those under Portuguese slaving and religious authority tell us much about sexual violence, slavery, and religious orthodoxy.
Taming the Global Financial Cycle: Central Banks as Shock Absorbers in the First Era of Globalization
Authors: Bazot Guillaume , Monnet Eric , Morys Matthias
Published: August 2022

The Classical Gold Standard period, with high capital mobility and fixed-exchange rates, is usually seen as the extreme case of international constraints on monetary policy. Contrary to this view, we show how central bank balance sheets offset the effects of international shocks on domestic interest rates. In contrast, in the United States, a gold standard country without a central bank, the reaction of money market rates was two to four times stronger than that of interest rates in countries with a central bank. Our study is based on the monthly balance sheets of all central banks in the world (i.e., 21) from 1891–1913.
Simulation-based teaching: an effective modality for providing UK foundation doctors with core ENT skills training
Authors: Jegatheeswaran L , Naing T K P , Choi B , Collins R , Luke L , Gokani S , Kulkarni S
Published: August 2022

Objective

This study aimed to assess the effectiveness of an ENT simulation course for equipping foundation doctors with core ENT skills in preparation for an ENT senior house officer post.

Method

A total of 41 foundation doctors in the East of England participated in our two-part simulation course. Pre- and post-course surveys, consisting of Likert scales and a Dundee Ready Educational Environment Measure, were sent to assess confidence in core ENT skills and acceptability of course format.

Results

Post-simulation, confidence improved in all core ENT skills taught (p < 0.001), along with confidence and preparedness to work as an ENT senior house officer (p < 0.001). Overall course median Dundee Ready Educational Environment Measure score was 48, and 100 per cent of participants would recommend this course to colleagues.

Conclusion

Simulation improves foundation doctors’ confidence in core ENT skills and increases preparedness for working as an ENT senior house officer. Guidance on core ENT skills requirements should be made available to improve uniformity amongst ENT simulation courses.
Strategic nest site selection in one of the world's largest loggerhead turtle nesting colonies, on Maio Island, Cabo Verde
Authors: Patino-Martinez Juan , Dos Passos Leno , Amador Raquel , Teixidor Arnau , Cardoso Sergio , Marco Adolfo , Koenen Franziska , Dutra Amanda , Eizaguirre Christophe , Dierickx Elisa G. , Tiwari Manjula , Székely Tamás , Moreno Rocío
Published: August 2022

For species without parental care, such as sea turtles, nest site selection is particularly important for embryo development, hatchling survival and, ultimately, reproductive success. We conducted an 8-year (2012–2019) capture–mark–recapture study of the re-nesting behaviour of loggerhead turtles Caretta caretta to identify both inter- and intra-beach patterns of nest site selection. Our study site, Maio Island in the archipelago of Cabo Verde, hosts one of the largest loggerhead turtle nesting colonies globally. Of 1,060 females analysed, 77% laid repeated clutches within 15 km of their previous nesting sites both between and within nesting seasons. This site fidelity was particularly high (64–71%) for turtles nesting on the east coast of Maio Island. In two areas of the island (north-west and south-east) individual nesting zone consistency was extremely low (10–25%). In all cases extra-zone re-nesting events mainly occurred on the east coast. We also found that females avoided re-nesting near the shoreline, which is particularly relevant in the context of rising sea levels. Overall, loggerhead turtles nesting in Maio Island are philopatric but are using a bet-edging strategy to distribute nests amongst several beaches, choosing the safest area within each beach to maximize their reproductive success. This study highlights the priority sites for protection on Maio Island and could help to optimize capture–mark–recapture programmes. The data reveal the potential for adaptive responses to projected sea level rises.
Texture and strain analysis of tungsten films via Tilt-A-Whirl methodology
Authors: Rodriguez Mark A. , Pillars Jamin , Valdez Nichole R. , Griego James J. M. , Gallegos Matthew V. , Krukar John A. , Polonsky Andrew , Wolfley Steven L.
Published: August 2022

Tungsten (W) films have many applications in the semiconducting industry for sensor technology. Deposition conditions can significantly impact the resulting W films in terms of the phases present (α-BCC or β-A12), microstructural grain orientation (texture), and residual strain. Tilt-A-Whirl methodology has been employed for the evaluation of a W film showing both texture and residual strain. Sin2(ψ) analysis of the film was performed to quantify the strongly tensile in-plane strain (+0.476%) with an estimated in-plane tensile stress of ~1.9 GPa. The 3D dataset was also evaluated qualitatively via 3D visualization. Visualization of 3D texture/strain data poses challenges due to peak broadening resulting from defocusing of the beam at high ψ tilt angles. To address this issue, principal component analysis (PCA) was employed to diagnose, model, and remove the broadening component from the diffraction data. Evaluation of the raw data and subsequent corrected data (after removal of defocusing effects) has been performed through projection of the data into a virtual 3D environment (via CAD2VR software) to qualitatively detect the impact of residual strain on the observed pole figure.
Climate Justice and Informal Representation
Authors: Hickey Colin
Published: August 2022

Abstract: What would constitute just representation for the climate vulnerable? My purpose in this essay is to provide a critique of the default frame for approaching this question, as well as to offer a suggestion for expanding our conception of what an adequate answer should include. The standard frame conceives of representing vulnerable climate interests largely in terms of formal mechanisms of representation in technocratic and bureaucratic institutions. I show the limits of that standard approach and caution against the discussion of climate representation being overly confined to the level of “formal” representation. I go on to detail the importance of thinking about more “informal” modes of representing vulnerable climate interests. In order to pursue both of these aims, I draw on lessons in meaningful representation and inclusion during postconflict peacebuilding.
Holding International Organizations Accountable: Toward a Right to Justification in Global Governance?
Authors: Reinold Theresa
Published: August 2022

This essay suggests that the accountability trends explored by Stian Øby Johansen and Gisela Hirschmann in their respective monographs should be viewed as indicating the emergence of a right to justification in global governance. Both Johansen and Hirschmann seek to advance the interdisciplinary conversation about the accountability of international organizations—Johansen by developing a normative framework assessing the quality of IO accountability mechanisms, and Hirschmann by seeking to identify the variables that shape the evolution of what she calls pluralist accountability. Building upon their analyses, I put forward a set of hypotheses about the procedural and substantive dimensions of the right to justification as well as the conditions for its consolidation in global governance.
A Professional Development Course for Political Science Undergraduates
Authors: Bram Curtis
Published: August 2022

This article describes a course designed to help political science majors formulate career goals, apply for internships and full-time positions, and eventually succeed on the job. Students benefit from exposure to guest speakers representing a range of careers and from collaborations with other campus institutions (e.g., the career center and graduate programs). Additionally, students produce job-market materials that highlight how their education has prepared them for life and work. Offering a similar professional-development course can help departments to increase enrollments and majors by increasing students’ confidence in the career prospects associated with their major.
Linguistic change and metre: the demise of adjectival inflections and the scansion of ‘high’ and ‘sly’ in Chaucer, Gower and Hoccleve
Authors: PUTTER AD
Published: August 2022

This article examines the inflectional system of adjectives in Chaucer, Gower and Hoccleve, with particular reference to the adjectives ‘high’ and ‘sly’. Since these poets were careful metrists, scansion allows us to determine the syllabic status of adjectives in their verse. While in Chaucer and Gower, the grammatical system for the inflection of monosyllabic adjectives (final -e for weak and plural adjectives) is generally observed, there is good evidence to show that the system was breaking down in the case of ‘high’ and ‘sly’, which frequently appear without inflection in weak position. The article also shows that in Hoccleve's poetry inflectional -e had disappeared altogether in these adjectives, except at line ending. Editorial emendations that depend on this inflection are therefore incorrect. The explanation for the irregular behaviour of ‘high’ and ‘sly’ is probably related to the vulnerability of schwa after front vowels.
Children's likelihood to perform adult-like in word association test: Effects of bilingualism and distributional properties of word relationships
Authors: Lam Boji P. W. , Sheng Li , Zhang Xian
Published: August 2022

Little is known about the effects of bilingualism and distributional properties of word relationships on children's development of semantic convergence, operationalized as children's ability to produce word associates that mirror adults’ responses in a word association task. Forty-five Mandarin–English bilingual, 32 Spanish–English bilingual, and 28 English-speaking monolingual children, aged 4 to 7, produced three associates to each of 15 single-word cues in English. Children's productions were compared against adult responses to the same cues in the “Small World of Words” Norm. Three scoring methods comparing similarities of children's responses to adults’ showed consistent bilingual disadvantages in producing adult-like responses. Follow-up analyses targeted the three most predominant responses adults produced for each cue and addressed factors predicting children's likelihood to produce these responses. Results showed additional effects of cue-associate relationships measured by co-occurrence and semantic relatedness. The findings highlight the multi-faceted nature of knowledge development of word relationship and semantic convergence.
Syllable Structure Spatially Distributed: Patterns of Monosyllables in German Dialects
Authors: Lameli Alfred
Published: August 2022

This study presents a micro-typological description of German dialects, focusing on the structure of 13,492 tokens of monosyllables, across 182 locations within Germany. Based on data from thePhonetischer Atlas der Bundesrepublik Deutschland, systematic geographical differences in both the segmental and prosodic organization of syllables are explored. The analysis reveals a North–South contrast in the organization of syllable structure. While the North tends toward more simple CVC syllables, the South tends toward the clustering of obstruents. An analysis of sonority dispersion reveals that in southern German, final demisyllables tend to follow more closely the sonority scale. Based on Markov chain models, the study reveals geographical differences in transition probabilities between the segments within monosyllables in German dialects.*
Faroese Preaspiration: A Nucleus/Onset Interaction Analysis
Authors: Voeltzel Laurence
Published: August 2022

This paper focuses on Faroese preaspiration, a phenomenon observed in Western Nordic and in some Eastern Nordic dialects, where fortis stops are preceded by a glottal frication noise in specific contexts. After observing all environments where the mechanism is triggered, I provide phonological representations of the phenomena based on Government Phonology 2.0. In this model, the segmental structures contain melody but also space, which allows for intersegmental relations such as lengthening, even without adding new morphological material. As preaspiration depends on the vowel preceding the fortis stop—more precisely, on its vocalic quality and length—I propose analyzing preaspiration as a spreading of the fortis consonant toward the vowel on the left. In doing so, I provide a unified analysis of all environments in which preaspiration occurs.*