bluuebunny/crossref_metadata_2025 huggingface dataset:
An Empirical Study on An Organized Industrial Zone: Investigating the Intermediary Function of Green Voice Behavior in the Connection between Green Human Resource Management and Environmental Performance
Authors: EDİNSEL Sercan
Published: October 2023

The aim of this study is to find the mediating role of green voice behavior (GVB) in the relationship between green human resource management (GHRM) and environmental performance (EP). In order to achieve the stated purpose, the study was conducted in Aydın organized industrial zone which encompasses 45 enterprieses. Data were collected by questionnaire method. And structural equation model (SEM) used in this study. 517 men and 180 women answered the questionnarie and a total of 697 questionnaires were returned. And nearly the half of this questionnaires (348) answered by food products manufacturing companies. The analyses in the study were conducted with SPSS 26 and AMOS programs. The result of the study shows that green promotive behavior (GPromVB or PROM) and green prohibitive behavior (GProhVB or PROH) has a partially mediator effect in the relationship between GHRM and EP. And GHRM has a significant effect on EP. Given the interdisciplinary nature of the study, it contributes to the integration of environmental management and Human Resource Management (HRM) theories and more holistic understanding of how organizations can effectively manage their environmental initiatives through GHRM. Based on the findings of the study, it contributes to the generalizability and external validity of GHRM principles. Furthermore, this study demonstrates that the mediating role of GVB is consistent across different organizational contexts and provides a valuable theoretical foundation for practitioners in various sectors. These results have implications for understandings about mediating role of GVB.
TEKNOLOGI COLLISION AVOIDANCE SYSTEM (CAS) TERHADAP UNSAFE ACTION DI PT XX
Authors: Riyan Saputra  , Dwi Yulia Maritasari  , Nur Sefa Arief Hermawan
Published: October 2023

Berdasarkan data, angka kecelakaan lalu lintas di PT XX tahun 2020-2022 cukup tinggi, sehingga diperlukan perbaikan untuk mencegah kecelakaan lalu lintas dengan cara mengimplementasikan teknologi Collision Avoidance System (CAS). Tujuan penelitian ini adalah untuk mengetahui penggunaan teknologi CAS terhadap Tindakan Tidak Aman lalu lintas pertambangan oleh operator dump truck di PT. XX dari tahun 2020-2022 berdasarkan waktu, area, dan jenis tindakan tidak aman. Metode penelitian yang digunakan adalah kuantitatif yang bersifat survei deskriptif. Analisis data yang digunakan adalah analisis univariat. Hasil penelitian menunjukkan 85,4% operator melakukan Tindakan Tidak Aman. Tindakan Tidak Aman berdasarkan waktu paling tinggi terjadi pada tahun 2021 yaitu 414.674. Tindakan Tidak Aman berdasarkan area paling tinggi terjadi pada Coal Mining Hauling yaitu 297.084. Tindakan Tidak Aman berdasarkan jenis Tindakan Tidak Aman paling tinggi terjadi pada stopsign yaitu 388.539. Saran pada penelitian ini adalah perbaikan segmen jalan tanjakan (overgrade) diatas 8%  dan penambahan suara alert teknologi CAS.
PEMANTAPAN MUTU INTERNAL PRA-ANALITIK PADA PEMERIKSAAN GLUKOSA DARAH PUASA DI LABORATORIUM DUREN SAWIT
Authors: Shafa Nabilah  , Enny Khotimah  , Intan Kurniawati Pramitaningrum
Published: October 2023

Pemantapan mutu internal adalah kegiatan pencegahan dan pengawasan yang dilakukan oleh laboratorium untuk mengendalikan dan mengetahui penyimpangan hasil laboratorium agar segera diperbaiki. Pemeriksaan glukosa darah puasa memerlukan pemantapan mutu internal. Kegiatan pemantapan mutu internal dibagi menjadi tiga tahap, yaitu pra-analitik, analitik dan pasca-analitik. Pada tahap pra-analitik terdapat total kesalahan terbesar yaitu 61%, sehingga dalam pelaksanaan tahap pra-analitik penerapan Standar Operasional Prosedur (SOP) harus diperhatikan. Tujuan penelitian ini untuk mengetahui penerapan Pemantapan Mutu Internal  tahap pra-analitik pada pemeriksaan glukosa darah puasa dengan melihat dari dua variabel yaitu standar operasional prosedur penerimaan pasien, pengambilan dan penanganan sampel. Metode penelitian ini dilakukan dengan cara kuesioner yang diisi secara langsung oleh ATLM yang bekerja di laboratorium RSKD Duren Sawit, dengan melibatkan 20 responden, data di analisis dengan uji validitas dan reabilitas. Hasil penelitian yang diperoleh bahwa ATLM yang bekerja di labratorium RSKD Duren Sawit sudah sangat baik, dilihat dari usia yang masih produktif, tingkat pendidikan yang sangat baik, dan pengalaman lama bekerja yang sangat baik. SOP pemeriksaan glukosa darah puasa tahap penerimaan pasien mendapatkan skor 95% dengan kategori sangat baik. Pada tahap pengambilan dan penanganan sampel mendapatkan skor 95% dengan kategori sangat baik. Sehingga ATLM sudah menerapkan SOP dengan sangat baik dan sesuai dengan standar laboratorium  RSKD Duren Sawit yang berlaku.
ANALISIS DESKRIPTIF: USIA DAN TINGKAT KEPATUHAN MINUM OBAT PASIEN DIABETES MELLITUS TIPE 2
Authors: Hijriyati Yoanita , Nur Ati Wulandari  , Aan Sutandi
Published: October 2023

Diabetes mellitus tipe 2 merupakan salah satu penyakit kronis yang dapat dikontrol dengan pengobatan yang teratur. Komplikasi dapat terjadi akibat ketidakpatuhan dalam pengobatan.   Usia merupakan salah satu faktor yang mempengaruhi kepatuhan minum obat, namun penelitian terkait hal ini belum banyak dilakukan di Rumah Sakit di Indonesia. Tujuan penelitian ini adalah untuk melakukan analisis deskripstif terhadap  faktor usia dan tingkat kepatuhan minum obat pada pasien diabetes mellitus tipe 2 di RSUPN Dr. Cipto Mangunkusumo. Penelitian ini menggunakan desain analisis deskriptif Cross-Sectional dengan teknik pengambilan sampel Insidental Sampling di Poliklinik Endokrin RSUPN Dr. Cipto Mangunkusumo, dengan jumlah sampel 64 responden. Hasil penelitian didapatkan mayoritas responden berada pada rentang usia 46 – 59 tahun yaitu pada usia pertengahan yang berjumlah 28 responden (43,7%), sedangkan untuk tingkat kepatuhan didapati 36 responden (53,1%) memiliki tingkat kepatuhan sedang, Hasil penelitian ini dapat dijadikan bahan rujukan bagi peningkatan pelayanan keperawatan di Rumah Sakit terhadap pasien di usia tertentu untuk meningkatkan kepatuhan minum obat khususnya bagi pasien Diabetes Mellitu tipe II yang diberikan secara komprehensif, dengan tetap melibatkan pasien dan keluarga dalam perawatan jangka panjang.
EFEKTIVITAS MEDIA FILTER KOMERSIL DAN BUATAN DALAM MENURUNKAN KONTAMINAN PADA AIR SUMUR YANG TERCEMAR
Authors: Rachmawati Nurmeily , Syarah Anliza  , Hamtini  , Jihad Madiabu
Published: October 2023

Lingkungan alam menyediakan sumber-sumber air diantaranya yang berasal dari tanah maupun dari sungai. Untuk mendapatkan air bersih yang layak diperlukan suatu usaha dalam perolehan dan pengolahannya melalui suatu proses filterisasi. Tujuan penelitian untuk mengetahui efektivitas media filter komersil dan buatan dalam menurunkan kontaminan. Metode penelitian ini ekperimental laboratorium dengan alat dan bahan diantaranya media komersil Zerni (arang aktif), media buatan (zeolith, pasir silica, sekam padi bakar), spektrofotometer (AAS), lactose broth, brilliant green lactose broth, dan peralatan gelas laboratorium. Parameter pada penelitian yaitu parameter fisika, kimia, dan biologi. Sampel berupa air sumur di lokasi Neglasari Rt/Rw 002/003 dengan kadar Fe yang cukup tinggi. Hasil pengukuran diperoleh kadar Fe diatas ambang batas yaitu 2,17 mg/L. Media komersil (arang aktif) efektif menurunkan kadar Fe, pasir silica efektif menurunkan total coliform, dan zeolite, pasir silica, sekam padi bakar efektif menurunkan kontaminan pada parameter fisika. Uji statistik dependent t-test menunjukkan thitung<ttabel sehingga adanya perbedaan signifikan.
REVIEW JURNAL: EPIDEMIOLOGI DAN PATOGENESIS PLASMODIUM VIVAX
Authors: Desi Aryani
Published: October 2023

Malaria adalah penyakit yang disebabkan oleh infeksi sel darah merah yang mengancam jiwa oleh parasit protozoa dari genus Plasmodium, yang ditularkan ke tubuh manusia melalui gigitan nyamuk Anopheles betina yang terinfeksi. Ada lima spesies Plasmodium (P. falciparum, P. vivax, P. malariae, P. ovale, P. Knowlesi),  Tujuan penelitian ini untuk mengetahui epidemiologi dan patogenesis Plasmodium vivax. Penelitian menggunakan metode literatur review dengan melalui peninjauan dokumen. Data didapatkan melalui peninjauan artikel dan jurnal terkait. Hasil kajian ini menunjukan bahwa Plasmodium vivax adalah yang paling umum dari semua jenis malaria, dapat menyebabkan infeksi serius, bahkan fatal, dan menyebabkan morbiditas dan mortalitas yang signifikan di seluruh dunia.
PENGARUH LATIHAN PERNAFASAN UNTUK MENGURANGI NYERI PADA PASIEN LUKA BAKAR: LITERATUR REVIEW
Authors: Vardha Anggina Pasaribu  , Dini Nur Alpiah
Published: October 2023

Luka bakar merupakan masalah yang paling umum terjadi pada semua rentang usia. Menajemen nyeri pada luka bakar merupakan bagian yang tidak dapat dipisahkan dalam perawatan pasien luka bakar. Tehnik latihan relaksasi pernafasan dan terapi latihan pasif merupakan suatu tehnik relaksasi yang bertujuan untuk mengurangi nyeri pada saat melakukan terapi pada luka bakar. Penelitian literature review dilakukan dengan menggunakan pencarian PICO di beberapa database seperti Google Scholar, Pubmed dan Science Direct. Didapat 5 jurnal yang memenuhi kriteria dan menunujukkan bahwa pemberian Tehnik Latihan Relaksasi Pernafasan yang dilakukan 20-25 menit selama 2-6 hari dengan p<0.05 yang menunjukkan adanya efek yang signifikan dalam intensitas nyeri selama perawatan luka pada pasien luka bakar. Sehingga dapat disimpulkan bahwa pemberian Latihan Tehnik Relaksasi Pernafasan pada saat melakukan terapi pada pasien luka bakar agar dapat menurunkan rasa nyeri selama perawatan luka bakar.
BURNOUT AND RELATED FACTORS IN HOSPITAL HEALTH WORKERS AFTER ONE YEAR OF COVID-19 PANDEMIC
Authors: Tri Mawanti Wening , Astrid Sulistomo  , Fijar Mohamad  , Marsha Vania  , Nofrizal N.
Published: October 2023

Workload, fear of contracting Covid-19 or the use of high levels of personal protective equipment which causes discomfort and exhaustion are some of the potential factors that can cause burnout in hospital health workers. The aims of this study were to determine the prevalence and factors related to burnout in hospital health workers after one year of the covid-19 pandemic. This study used a cross-sectional design and the Indonesian version of the Maslach Burnout Inventory (MBI) questionnaire to diagnose burnout. In the Masclach Burnout Inventory (MBI) questionnaire, burnout is grouped into the following three dimensions: a) emotional fatigue, b) loss of empathy, and c) self-esteem. The MBI questionnaire was distributed using a Google form (G-form). Data processing and analysing was conducted using SPSS version 20.0 program. A total of 135 health workers filled out the G-form questionnaire and it was found that 39.3% of them experienced burnout.  Factors significantly related (p<0,05) to burnout were higher education with ORa 4.10 (95% C.I.= 1.66 – 7.27) and shift work with ORa 2.44 (95% C.I.= 1.02 -5.86). The prevalence of burnout for health workers at the one of private Hospital in East Jakarta after more than 1 year of the Covid-19 pandemic was 39.3%. Factors that are significantly related to burnout are the level of education and shift work patterns.
EVALUASI PENGGUNAAN ANTIBIOTIK PROFILAKSIS DAN OBAT TERAPI COVID-19 PADA PASIEN SC TERKONFIRMASI COVID-19
Authors: Yulianah  , Dian Ratih  , Yuanna Dewi
Published: October 2023

Antibiotik profilaksis merupakan antibiotik yang diberikan pada pasien yang akan menajalani pembedahan untuk mencegah terjadinya infeksi akibat tindakan operasi. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik profilaksis dan obat terapi covid-19 pada pasien sectio caesarea. Penelitian ini adalah penelitian retrospektif yang diambil dari catatan rekam medik pasien. Jumlah sampel pada penelitian ini  adalah 111 pasien. Analisa yang digunakan dengan uji statistik Chi-Square. Hasil penelitian menunjukan Length of Stay (LOS) 7 hari masih positif tanpa gejala sebanyak 64 orang (58%) sedangkan yang Length of Stay (LOS) diatas 7 hari sebanyak 47 orang (42%). Untuk Infeksi Daerah Operasi(IDO) 10 orang (9%) yang terinfeksi dan tidak ada Infeksi Daerah Operasi (IDO) sebanyak 101 orang (91%). Jenis antibiotik Profilaksisnya Cefazolin Injeksi(Inj) sebanyak 25 orang (23%),  Ceftriaxone Inj  sebanyak 59 orang (53%), Cefuroxim Inj sebanyak 13 orang (12%), Ampicillin sulbactam Injeksi(Inj) sebanyak 13 orang (12%) dan Levofloxacin Inj sebanyak 1 orang (1%).  Pasien  yang tidak mendapatkan antiviral  sebanyak 99 orang (89%), yang mendapatkan Favipiravir tablet sebanyak 8 orang (7%) dan yang mendapatkan  Remdesivir inj sebanyak 4 orang (4%). Tidak ada hubungan yang signifikan antara jenis antibiotik dengan kejadian IDO  dan tidak ada hubungan yang signifikan antara pemberian antiviral dengan LOS dan terdapat hubungan.
ANALISIS AKUNTABILITAS DAN TRANSPARANSI PENGELOLAAN ALOKASI DANA DESA DI KECAMATAN JONGGOL KABUPATEN BOGOR
Authors: Intan Dhea Yolanda  , Fitrawansyah  , Udin Saepudin
Published: October 2023

Analisis Akuntabilitas dan Transparansi Pengelolaan Alokasi Dana Desa. Penelitian ini adalah penelitian kualitatif memakai pendekatan naratif menggunakan mengumpulkan data-data penelitian buat dikondensasi serta tersaji secara jelas supaya bisa menarik sebuah konklusi melalui observasi, wawancara, serta dokumentasi. Hasil penelitian ini menunjukkan bahwa pertanggungjawaban Desa Sukaisrna akuntabel dan konsisten dengan Permendagri No. 20 Tahun 2018. Desa Sukasirna memberitahukan APB Desa dalam bentuk poster yang dapat dilihat langsung oleh masyarakat setempat. Sedangkan tahap transparansi tidak sesuai dengan Permendagri nomor 20 tahun 2018, karena terdapat informasi laporan pelaksanaan kegiatan yang belum selesai dan dilaksanakan,  Laporan Realisasi Pertanggungjawaban Desa Sukasirna atas pelaksanaan APB, penggunaan ADD yang diterima Desa Sukasirna digunakan untuk 4 bidang yaitu, (1) Bidang Penyelenggara Pemerintahan Desa Rp. 1.078.716.782,- (2) Bidang Pelaksanaan Pembangunan Desa Rp.1.681.326.540,- (3) Bidang Pembinaan Kemasyarakatan Rp.89.400.000,- dan (4) Bidang Pemberdayaan Masyarakat Rp.42.600.000,-.
Electrochemical Analysis of Clinical Samples – A Path to Translational Research
Authors: Moráňová Ludmila , Bartošík Martin , Strmisková Johana , Nováková Kateřina
Published: October 2023

Precise diagnostics of cancer or other diseases is crucial when selecting proper treatment. Personalized medicine puts high demands on the accuracy of nucleic acid biomarkers analysis, where subtle differences at the nucleotide level are often involved. Isothermal amplification techniques offer new possibilities of DNA and RNA amplification without using PCR, and their combination with electrochemistry provide a promising fast and cost-effective alternative diagnostic tool. Although electrochemical biosensors are still insufficiently applied to clinical material, thus hindering their development, recent advancements show great promise in translational research. Banks of biological material (biobanks) are specialized workplaces focused on the long-term preservation and processing of clinical material and offer a wide range of expert services, primarily for research purposes, in particular the provision of biological samples and associated pseudonymized data. Their involvement in the field of electrochemical biosensors can facilitate application of electrochemical methods into clinical laboratories and expand the portfolio of currently used diagnostic methods.
Covalently Functionalized Graphene Derivatives as Active Electrode Materials for Supercapacitors
Authors: Šedajová Veronika , Bakandritsos Aristeidis , Otyepka Michal
Published: October 2023

Research efforts for supercapacitor electrode materials have become increasingly important due to the high demand for long-lasting, high-performing and environmentally friendly portable energy storage devices. Graphene-based materials and their hybrids have been shown to be very promising candidates for meeting these requirements. This short review summarizes recent advances in the development of graphene derivatives and focuses in particular on materials derived from graphite fluoride. Covalent graphene derivatives belong to a progressive class of highly efficient materials with tailorable structural and physicochemical properties that can be adapted to meet specific capacitive charge storage requirements, and, thus, enhance the most effective development of the energy storage field.
Methods for Nitrogen Fixation and Its Reduction to Ammonia
Authors: Jarolímková Jaroslava , Kolská Zdeňka
Published: October 2023

The research and development of novel materials to produce ammonia from atmospheric nitrogen at atmospheric pressure and room temperature is a hot topic at the present time. Even today, ammonia is still being produced using the conventional Haber-Bosch synthesis, which requires high pressures and temperatures and uses fossil fuels, thus producing significant greenhouse gas emissions. This work is therefore focused on the possibility of preparation and research of new materials capable to fix atmospheric nitrogen and convert it to ammonia under mild conditions. Photocatalysis, electrocatalysis, plasmonic structures, and their combinations can be used for such reductions. In addition to that, this study outlines the advances achieved so far, as well as the general background of the subject.
Chairmen of Slovak Chemists' Associations until the End of the 20ᵗʰ Century
Authors: Drašar Pavel , Milata Viktor
Published: October 2023

The article lists the presidents of Slovak chemists' associations from 1929 to the end of the 20th century.
Bioplastics, as Seen by University Students
Authors: Nová Martina , Šmejkalová Pavla
Published: October 2023

The study focuses on the issue of bioplastics from a societal perspective. The surveyed group were students of bachelor and master programs of the University of Chemical Technology Prague, the aim was to map the awareness of bioplastics within the group of university students specialized in chemistry in the Czech Republic. The influence of gender and environmental education on decision making was also investigated. It showed that gender influences decision-making on environmental issues, with women giving more weight to sustainability and zero-waste bioplastics, as well as to the potential positive impact of bioplastics on climate change and water pollution reduction. Men are more pragmatic in their decision-making, giving more priority to material and economic aspects. In the case of the influence of vocational education, environmental students showed a greater tendency towards sustainable behaviour. However, given the small sample of environmental respondents, this hypothesis needs to be confirmed by further research.
Formulasi Dan Uji Anti-Aging Krim Ekstrak Etanol Daun Jelatang (Urtica dioica L.)
Authors: Widiyawati Rinda Septi Putri , Albari Akhmad , Basith Abdul
Published: October 2023

Daun jelatang merupakan semak asli Eropa utara dan Asia. Daun jelatang memuat karoten, vitamin C, senyawa polisakarida, dan flavonoid, quercetin, beta-sitosterol dan kaempferol. Tujuan dari penelitian ini untuk mengetahui pembuatan krim anti-aging dengan pemanfaatan ekstrak etanol daun jelatang dan mengetahui konsentrasi terbaik dari krim ekstrak etanol daun jelatang yang memiliki pengaruh anti-aging. Jenis penelitian yang dilakukan adalah percobaan kuantitatif dengan desain true experimental dan Rancangan Acak Lengkap (RAL). Sampel yang digunakan pada penelitian kali ini adalah tanaman daun jelatang (Urtica dioica L.) dengan konsentrasi 5%, 10%, dan 15%. Hasil penelitian menunjukkan bahwa sediaan krim enstrak etanol daun jelatang (Urtica dioica L.) dengan konsentrasi 5%, 10%, dan 15% menghasilkan sediaan krim yang memiliki warna, aroma, rasa serta tekstur yang baik dan memenuhi standart SNI. pH sediaan krim berkisar 5-6, dan tidak menyebabkan iritasi pada kulit. Hasil uji one- way anova pada kadar air (Moisturizer), pori (Pore), noda (Spot) dan keriput (Wrinkle) menunjukkan tidak adanya perbedaan signifikan antar formula. Kesimpulan dari penelitian ini Ekstrak etanol daun jelatang (Urtica dioica L.) dapat diformulasikan sebagai sediaan krim yang homogen dengan pH 5 , daya sebar 5 cm , daya lekat 8,62 detik, yang memenuhi standart SNI dan tidak menimbulkan iritasi pada kulit dan setabil pada penyimpanan selama 14 hari serta mampu memberikan efek anti-aging terhadap sukarelawan.
Effects of dental age on proximate components, amino acid and fatty acid profiles of indigenous beef
Authors: Islam MS , Hossain MM , Akhter S , Goswami PK , Al Noman MA , Mustari A , Hashem MA
Published: October 2023

The study was conducted to determine how the proximate composition, amino acid and fatty acid profiles of beef of indigenous cattle are affected by dental age. This experiment was conducted with five (5) treatments (T1, T2, T3, T4, and T5) where T1 = 0 Permanent incisors, T2 = 2 Permanent incisors, T3 = 4 Permanent incisors, T4 = 6 Permanent incisors, T5 = 8 Permanent incisors having ten (10) replications. This study has shown that the highest CP was 84.91% having the T5 while the lowest figure was 72.94% in T4. T1 had the lowest 3.34% EE content whereas T5 had the highest 4.15%. Essential amino acids (g/100g of meat) were highest at 41.51 in T5 and lowest at 37.79 in T1. The lowest total saturated fatty acid (SFA) in Longissimus dorsi was 46.25% in T5 and the highest was 51.89% in T1. The total monounsaturated fatty acid (MUFA) proportion of 66.87% in T2 was the highest and T5 had the lowest proportion of 52.07%. The lowest total polyunsaturated fatty acid (PUFA) was 1.52% in T1 and the highest was at 7.49% in T5. In conclusion, CP, EE, essential amino acid, and polyunsaturated (PUFA) fatty acid proportion increased with the advancement of dental age maturity and conversely, saturated fatty acid (SFA) proportion was decreased. Therefore, this research will play a vital role to characterize accurately in terms of its nutritional quality to be aware of the selection of indigenous beef in their daily diet according to dental age.
Study on socio-economic condition of butchers and trend of market price of red meat at some selected areas in Bangladesh
Authors: Roy BK , Tule SA , Sarkar NR , Billah MM
Published: October 2023

The study was aimed to assess the socio-economic status of butchers and trend of market price of meat changed from last nine (09) years at five (05) selected areas in Bangladesh such as Dhaka, Chittagong, Rajshahi, Khulna and Rangpur City Corporation. The study was carried out through a structured questionnaire among seventy five (75) selected butchers each survey time where fifteen (15) in each area. The survey was conducted from January to August, 2014 and February to May, 2023. During survey the considered parameters were the butchers age, level of education, family size, land size, housing, source of capital andcurrent red meat price. Result from the study revealed that the respondents average aged in Dhaka, Chittagong, Rajshahi, Khulna and Rangpur city corporation were 40.30, 34.27, 36.27, 36.40 and 35.00, respectively and all of them were male. For literacy rate of respondents it was found that about 56% butchers were had secondary level education, 38.67% butchers had primary level education, 4% had higher secondary level education and only 1.33% were graduate. About 88.23% butchers solely depend on meat processing but along with meat processing 4.71% respondents were engaged with business and 7.06% respondents were engaged with agriculture. In 2014, it was found that all type of meat (beef, buffen, chevon and mutton) price were highest in Dhaka and it was average 582.00, 562.50, 900.00 and 870.00 TK in Chittagong, Khulna, Rajshahi and Rangpur, respectively. In case of Chevon market price was 895.00, 882.00, 870.71 and 865.09 in Rajshahi, Chittagong, Rangpur and Khulna, respectively. For Mutton it was 830.00, 820.00, 820.00 and 816.00 TK in Chittagong, Rajshahi, Rangpur and Khulna, respectively. It was found that market price increased so rapidly and the rate of increasing percentage for beef, buffen, chevon and mutton were 195.27%, 193.76%, 154.83% and 169.93%, respectively. Overall slaughtered number of cattle, buffalo, goat and sheep per week in selected areas were 42.84, 7.47, 23.29 and 4.84, respectively.
Understanding obstructive sleep apnea
Authors: Aini Nur , Nguyen Trung V. , Khairi Sabiah
Published: October 2023

Obstructive sleep apnea (OSA) is defined by repeated episodes of partial or complete upper airway collapse, obstructing breathing during sleep. OSA is a dangerous health condition with high mortality and morbidity. Due to the rising prevalence of obesity, OSA is on the rise in developing countries. Nevertheless, the exact number of OSA prevalence among Indonesian people is unrecognized for several reasons; for instance, low awareness of sleep disorder issues, unawareness of the symptoms and impact of OSA, limited access to polysomnography examinations, and considering snoring as a common condition. Long-term health effects, decreased sleep quality, psychological issues, and cognitive impairment are all linked to untreated OSA. Nurses can contribute to the management of OSA by conducting screening and assessment, providing health promotion to patients, and coordinating with other healthcare providers. This paper explores the prevalence of OSA, society’s perception of OSA, diagnostic or screening procedures, and treatment options for the effective management of OSA.
Aplicación de la inteligencia artificial en la gestión del dolor en pacientes postoperatorios: revisión bibliográfica
Authors: Montero Bustamante Frank Sebastián , Barzallo Correa Luis Felipe
Published: October 2023

Introducción: el artículo explora la evolución de la atención postoperatoria y su relación con los avances científicos y tecnológicos en la medicina. Se destaca el desafío del manejo efectivo del dolor postoperatorio y su impacto en la experiencia y recuperación del paciente.
Objetivo: el objetivo principal del artículo es profundizar en la intersección entre la inteligencia artificial (IA) y el cuidado postoperatorio. El enfoque es explorar cómo la IA puede mejorar la gestión del dolor postoperatorio, examinando técnicas actuales y su impacto en la vida real de los pacientes.
Desarrollo: se presentan los resultados de varios estudios que exploran la aplicación de la IA en el manejo del dolor postoperatorio. Los estudios incluyen la predicción del uso prolongado de opioides después de la cirugía, la evaluación del dolor mediante el reconocimiento de expresiones faciales y la revisión de técnicas actuales y limitaciones en el uso de la IA en anestesiología.
Conclusión: la IA se ha demostrado valiosa en el manejo del dolor postoperatorio, ofreciendo soluciones innovadoras como la predicción de uso prolongado de opioides y la evaluación del dolor a través de expresiones faciales. Se destaca la importancia de un enfoque preventivo, la colaboración interdisciplinaria y la rigurosidad en la implementación de la IA en la atención médica. Aunque prometedora, la IA también presenta desafíos que deben abordarse.
Vasculitis Renal Lupica con Debut De Psoriasis
Authors: Gálvez Vallejo Juan Fernando , Zumba Tenesaca Pablo Esteban , Salamea Sarmiento Cecibel Johanna
Published: October 2023

Introducción: La vasculitis renal lúpica con debut de psoriasis por ser una enfermedad de poca incidencia de casos, no cuenta con estudios significativos, su diagnóstico en su mayoría es infrecuente. Con el presente trabajo de investigación se pretende el análisis de caso de paciente con diagnóstico de enfermedad antes mencionada, con el fin de conocer el proceso de enfermedad de la paciente, la misma que tuvo un diagnóstico inicial de psoriasis y posterior vasculitis lúpica.

Caso clínico: Paciente femenino de 37 años de edad, sin antecedentes patológicos de importancia, presenta cuadro clínico de 10 años de evolución, caracterizado por lesiones generalizadas, presentándose en extremidades superiores, tronco y extremidades inferiores, acude a reumatología presentando elevación de reactantes de fase aguda, ANA positivo. La biopsia de piel reporta lesiones psoriasiformes. Posterior acude nuevamente a consulta presentando astenia, edema, fiebre, alteración de la función renal, reactantes de fase aguda elevados y biopsia renal reporta vasculitis de pequeños vasos pauciinmune, siendo tratada con corticoesteroides e inmunosupresores, manteniendo en remisión.

Conclusión: La vasculitis renal lúpica con psoriasis, es una asociación infrecuente, como consecuencia de un deficiente estudio de esta, provoca retardado en el diagnóstico y por ende afección significativa del sistema renal en los pequeños y medianos vasos.
Design and Assessment of a Microemulsion-Based Transdermal Drug Delivery System for Meloxicam; Examination of Formulation Ingredients
Authors: SALİMİ Anayatollah , NOORAFROOZ Ramin , FOULADİ Maryam , MOHAMMAD SOLEYMANİ Saeed
Published: October 2023

Background: The goal of creating meloxicam-loaded microemulsion formulations was to increase meloxicam permeability through the skin. Using pseudo-ternary phase diagram construction and full factorial design, eight formulations with three independent variables (water percent, oil percent, and surfactant/co-surfactant percent) were selected to be prepared.

Methods: This research evaluated the formulation's characteristics, including particle size, viscosity, and release profile. FT-IR and DSC techniques were also utilized to investigate the effect of microemulsion components on rat abdomen skin, and the permeability of meloxicam-loaded microemulsions via rat abdomen skin was also evaluated by calculating permeability parameters such as Jss, Dapp, Tlag, ERflux, ERD, and ERP.

Results: When compared to a saturated aqueous solution of meloxicam as a reference, the findings showed that all microemulsion (ME) formulations considerably increased meloxicam permeability through rat skin. Water percent had a direct and significant relationship with Jss, and oil percent had a direct and significant relationship with Dapp, according to analysis regression.

Conclusion: ME components also caused alterations in the skin's lipoprotein bilayers, which might enhance formulation permeability through the skin.
Phase Transformation of Anhydrous to Dihydrate Carbamazepine: Preparation and Comparative Characterization
Authors: WADHER Kamlesh J , RAUT Vaishnavi , HİRAVE Keshav , TRİVEDİ Sagar , UMEKAR Milind
Published: October 2023

Carbamazepine, an anticonvulsant drug is one of the suitable activecompounds for the study of crystal and polymorphism study. Hydrate formation or dehydration of a given hydrate may affect the overall performance of the ultimate formulations and it has been estimated that more than 30 % available active drug compound can form a hydrate. The anhydrous form of the compound always shows higher aqueous solubility and dissolution parameter as compared to hydrates. This ultimately led to improved bioavailability when the rate limiting step for the absorption is dissolution rate. The purpose of the present investigation was to compare various techniques for the formation of Carbamazepine dihydrate from anhydrates and also to discriminate crystal forms of Carbamazepine by Melting point, FTIR, DSC, Powder X-ray diffractometry analysis, NMR, scanning electron microscopy, solubility and intrinsic dissolution testing. Carbamazepine phase transformation of solid state occurs when exposed to the environmental condition, which can affect the performance of the drug and the formulations.
Mucoadhesive Drug Delivery Systems for Pediatric and Geriatric Patients
Authors: RAİ Arya , RAWAT Shristhi Sohan , RATHİ Ritu , RAİNA Deepika , ODEKU Oluwatoyin A. , SİNGH Inderbir
Published: October 2023

A mucoadhesive drug delivery system (MDDS) has been a smart approach to the delivery of drugs at the target site. In MDDS mucus membrane and type of polymer plays an important role in the mucoadhesion phenomenon. To explain the mechanism behind mucoadhesion, various theories have been proposed such as electronic, adsorption, wetting, diffusion, and fracture theory. MDDS has been beneficial to some special patients, preferably pediatric and geriatric. Several challenges such as taste masking, dose determination, dosage form spitting, target delivery, the bioavailability of the drug, adverse drug reaction, toxicity, etc. are faced while developing any delivery system for these special patient populations. Keeping these challenges in mind several researchers have attempted to design and formulate MDDS according to their convenience. The current review focuses on a basic overview of mucoadhesion, various theories of mucoadhesion, and mucoadhesive polymers. The later part of the review focuses on the MDDS for pediatric and geriatric patients with their significance. Various patented formulations and clinical trials going on for these populations have also been discussed.
Evaluation of the effect of topotecan, carvacrol, epigallocatechin gallate and their combination on apoptotic process in neuroblastoma and astrocyte cells
Authors: OLTULU Çağatay , AKINCI Melek , BAKAR Elvan
Published: October 2023

Neuroblastoma is the sympathetic nervous system cancer. It most commonly affects children under 5 years of age and is the most common solid tumor in childhood. Topotecan is a topoisomerase 1 inhibitor. Carvacrol and Epigallocatechin gallate are naturally derived substances with anticancer, antioxidant, and apoptotic properties. The aim of our study was to evaluate the effects of topotecan, carvacrol, EGCG, topotecan+carvacrol, and topotecan+ epigallocatechin gallate combinations on the apoptotic signaling pathway. IC50 values were determined in neuroblastoma and healthy astrocyte cells using the MTT assay. Apoptotic mRNA expressions (topoisomerase 1 and 2, p53, BCL2, BAX, caspase 9, caspase 3, IL1, TNFα) in astrocytes and neuroblastoma cells at the neuroblastoma IC50 dose were analyzed using quantitative real-time PCR. We found that topotecan and carvacrol did not exhibit selective cytotoxic effects between healthy astrocytes and neuroblastoma cells. However, we found that the combination of topotecan+ epigallocatechin gallate and topotecan+carvacrol with epigallocatechin gallate showed selective cytotoxic effects on the neuroblastoma cell line compared to astrocyte cells. The obtained mRNA results can be interpreted as the initiation of apoptosis in neuroblastoma cells in the topotecan, carvacrol, epigallocatechin gallate, and topotecan+epigallocatechin gallate groups. Further studies are needed to investigate this matter in more detail.
Interpretable QSAR Modelling and QSAR-Based Virtual Screening of Novel 3H-Thiazolo[4,5-b]pyridin-2-one Derivatives as Potential Antioxidant Drug Candidates
Authors: KLENİNA Olena
Published: October 2023

Quantitative structure-activity relationship (QSAR) study has been carried out for 32 N3 substituted 3H-thiazolo[4,5-b]pyridin-2-one derivatives as potential antioxidant drug candidates. The genetic algorithm (GA) and multiple linear regression analysis (MLRA) were used as appropriate techniques for descriptors selection and correlation models generation. The four best regressions for the prediction of the ability to scavenge the DPPH radical were generated as three-parameter QSAR models with the highest statistical characteristics and predictive ability. Based on the validation parameters of the generated models, it may be stated that they all satisfy the statistical requirements for their goodness-of-fitting with no current overfitting. The predictive ability of the constructed models was assessed with both internal and external validation approach and estimated with the leave-one-out and leave-group-out cross-validation coefficients (Q2LOO and Q2LGO). The values of Q2LOO (0.7060  0.7480) and Q2LGO (0.6647  0.7711) are reasonable, showing that the models are significant and robust to predict the free radical scavenging activity of the compounds from both training and validation sets. Applicability domain defining technique was employed to the obtained models and it was indicated that most structures were adequately represented by the chemical space of the models.
Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application
Authors: ÖZCAN Kutsal , İLBASMIŞ TAMER Sibel , SARAL ACARCA Eylül Su
Published: October 2023

Sertraline is one of the selective serotonin reuptake inhibitors indicated in major depressive disorder. Schizophrenia is a mental disorder with frequent depressive symptoms. Sertraline is thought to be useful for the treatment of depressive symptoms in schizophrenia. The objective of this study is to formulate sertraline-containing nanofiber strips produced by the electrospinning process, which can be easily dispersed by the buccal route, suitable for the use of schizophrenia patients. Here, various ratios (%5, %7.5 and %10) of polyvinyl pyrrolidone (PVP) polymer solutions were prepared, and electrical conductivity, viscosity and surface tension characterization studies were performed on polymer solutions. After characterization studies, a polymer solution containing 5% PVP was selected to prepare nanofibers. Nanofibers were obtained by using the electrospinning method, each strip containing 5 mg sertraline. It was observed that the optimum formulation selected nanofiber had an average particle diameter of 371-439 nm in the SEM image. Tensile strength and elongation at break percentage values of 5% PVP-sertraline nanofibers values were 0.449±0.284 (Mpa) and 22.6±3.66 (%), respectively. The loading capacity and encapsulation efficiency of the formulation are 4.53%±0.31 and 79.61±10.56 respectively. In vitro drug dissolution studies showed that sertraline-containing buccal nanofibers conformed to the Hixson-Crowell kinetic model.
Synthesis of some novel Schiff base derivative 5-substituted-4-amino-1,2,4-triazole-3-one compounds with potential lipase inhibition activity
Authors: KAHVECİ Yaren , DOĞAN İnci Selin , KANBOLAT Şeyda , KAHVECİ Bahittin
Published: October 2023

Bu çalışmada triazol-imidazol halkaları içeren 5 yeni Schiff bazı bileşiği sentezlendi. Bu ikili sistemi içeren bileşikler, heterosiklik imin türevi bileşikler için gerçekleştirilmiştir. Literatür bilgilerine göre, elde edilen bu bileşiklerin antikonvülsan ve antimikrobiyal aktiviteler gibi potansiyel biyolojik aktivitelere sahip olması beklenmektedir. Sentezin birinci basamağında, aril/alkil nitril bileşiklerinden Pinner yöntemi ile iminoster türevi bileşikleri (la-e) elde edildi. İkinci aşamada, aril/alkil iminoester (la-e) bileşiklerinin etoksikarbonil hidrazin bileşiği ile reaksiyonu sonucu ester etoksikarbonil türevi bileşikler (2a-e) elde edildi. Ortaya çıkan ester etoksikarbonil hidrazonlar, hidrazin hidrat ile reaksiyona sokuldu ve literatürde verilen yöntem kullanılarak karşılık gelen triazol-amin (3a-e) bileşikleri elde edildi. Çalışmanın orijinal basamağında, 5-substitue-4-amino-1,2,4-triazol-3-on bileşikleri (3a-e), 4-imidazol karboksialdehit ve beş yeni Schiff bazı 4-{[((1H-imidazol-4-il)metilen]amino}-5-substitue-2,4-dihidro-3H-1,2,4-triazol-3-on bileşikleri (4a-e) elde edildi. Bu çalışmada, 5 yeni 5- substitue-4-{[(1H-İmidazol-4-il)metilen]amino}-2,4-dihidro-3H-1,2,4-triazol-3-on (4a-e) sentezlendi ve fiziksel özellikleri ile bileşiklerin yapılarının aydınlatılması için IR, 1H-NMR ve 13C-NMR spektral analizleri yapılmıştır. Elde edilen yeni Schiff bazı bileşiklerinin pankreatik lipaz enzim inhibisyon aktiviteleri incelenmiştir. Pozitif kontrol Orlistat’a karşı ortalama aktivite göstermişlerdir
Synthesis and Biological Evaluation of Novel Paracetamol-Triazole Conjugates
Authors: KULABAŞ Necla , GÜRBOĞA Merve , BİNGÖL ÖZAKPINAR Özlem , LİU Jianyang , JAKOBSSON Per-johan , DANIŞ Özkan , OGAN Ayşe , KÜÇÜKGÜZEL İlkay
Published: October 2023

Some new triazole containing acetamide derivatives 9-20 using paracetamol as starting material were synthesized and their structure were characterized by FTIR, 1H-NMR, 13C-NMR and MS data. In vitro cytotoxic activities of all synthesized molecules against five cancer cell lines (human lung cancer A549, human chronic myelogenous leukemia K562, human breast cancer MCF-7, human prostate cancer PC-3, human neuroblastoma SH-SY5Y cell lines) were examined and were also tested their cytotoxic effect on mouse embryonic fibroblast cells (NIH/3T3) to define selectivity. MTT assay were used these in vitro activity studies. Additionally, twelve target compounds 9-20 were screened for their mPGES-1 and COX-1/2 inhibitory activities. While none of the synthesized compounds showed a significant inhibition against both cancer cells and mPGES-1 as well as COX-1/2, it was determined that they were not cytotoxic against healthy cells, too. Finally, ADMET data were presented by predicting the drug-like properties of newly synthesized compounds using computational methods.
Anticancer Potential of Novel Nanoemulgel Formulations in Melanoma
Authors: TİMUR Selin Seda
Published: October 2023

Melanoma is classified as one of the most common cancers with an increasing incidence rate and the conventional treatment options that come with undesirable effects decrease the life quality of patients. Herein, as an alternative therapy option for systemic administration, Carbopol-based nanoemulgel formulations for local delivery were designed. Topical drug delivery systems containing Oxaliplatin, a cisplatin derivative anticancer drug used in the treatment of colorectal cancers, were evaluated for their potential for melanoma treatment. Nanoemulgel formulations with particle size under 300 nm were prepared and characterized in terms of droplet size, zeta potential and liquid crystal formation. The viscosity, as a critical attribute for topical drug delivery systems, was also evaluated, and pseudoplastic behavior of these novel drug delivery systems were confirmed. The controlled drug release pattern was shown with in vitro drug release studies with a significant difference from oxaliplatin when applied in solution. In vitro cell viability evaluation with L929 mouse fibroblast cell line confirmed the biocompatibility of prepared formulations, and the anticancer effect of novel nanoemulgel formulations were presented in B16-F10 mouse melanoma cell line. In conclusion, the anticancer potential of Oxaliplatin nanoemulgels were shown in vitro as a therapy option for melanoma, and the advantages of emulsion and gel-based drug delivery systems were combined in a nanotechnology platform for effective and patient-friendly application of an anticancer therapy for melanoma.
Metabolomic Studies in Girls With Central and Peripheral Precocious Puberty
Authors: BALCI ÖZYURT Aylin , REÇBER Tuba , NEMUTLU Emirhan , BULUŞ Derya , KIR Sedef , KOÇER GÜMÜŞEL Belma , ERKEKOĞLU Pınar
Published: October 2023

Puberte prekoks (PP), kızlarda sekonder cinsel özelliklerin sekiz yaşından önce başlamasıdır. Hipotalamus hipofiz-gonad ekseninin erken aktivasyonu nedeniyle "merkezi puberte prekoks (CPP)" meydana gelir. "Periferik puberte prekoks (PPP)" hipotalamus-hipofiz-gonad (HPG) aksına bağlı olmayan daha nadir görülen farklı bir durumdur ve periferik nedenlere bağlıdır. Metabolomiks, küçük molekül metabolitlerinin (
NLRP3 expression in peripheral blood mononuclear cells of patients with rheumatoid arthritis
Authors: YILMAZ SARIALTIN Sezen , KÜÇÜKŞAHİN Orhan , NURAL Cemil , KOZACI Leyla Didem , KAYGIN Pınar , GÜLER ŞİMŞEK Gülçin , OĞUZTÜZÜN Serpil , ÇOBAN Tülay
Published: October 2023

Rheumatoid arthritis (RA) is a systemic autoimmune disease mainly characterized by painful, swollen, and inflamed joints. Individual, genetic, and environmental factors influence the development of the disease, which causes involvement not only in the joints but also in other extra-articular tissues. However, its etiopathogenesis has not been fully elucidated yet. NLRP3, which is a key component of innate immune system, may contribute to recurrent and chronic inflammation, resulting in inflammation-related diseases. Therefore, we aimed to investigate the expression profile of NLRP3 in peripheral blood mononuclear cells isolated from patients with RA using immunocytochemical approaches in this study. Our findings demonstrated that NLRP3 expression was significantly increased in patients with RA in comparison with the healthy controls (p
Drug Administration via Feeding Tube in Intensive Care Unit: A Cross-sectional Study
Authors: SURMELİOGLU Nursel , İLERİ Yaren , GÜNDÜZ H Murat , ÖZCENGİZ Dilek
Published: October 2023

Aim: The aim of this study was to evaluate the appropriateness of the administration of drugs in critically ill patients receiving enteral feeding support. .

Materials and methods: This prospective, observational, and descriptive study was conducted in the reanimation unit of a university hospital. A clinical pharmacist on the intensive care team evaluated the drug administration of enterally fed patients at daily visits. The necessary interventions for incorrect drug administration via the feeding tube detected in the patient’s treatment were reported to the responsible physician.

Results: Thirty patients who met the relevant criteria 2022 were included in the study. Fifteen (50%) of the patients were female, and the mean age of all patients was calculated as 49.16±20.23. It was determined that 76% of the patients received nutritional support via feding tube. The appropriateness of 74 drugs, 36 of which were different, administered via the feeding tube of these patients was evaluated. Thirty-three of the 36 medications were in solid dosage form Most of the drugs administrated by tube (94.6%) were in dose form appropriate for tube administration, whereas 17.56% of the administration method was incorrect.

Conclusion: Unlike the recommendations, solid dosage forms are primarily applied in drug administrations made via feeding tubes. It is thought that the creation of algorithms that can be used in clinical practice for the correct method of administering the limited number of drugs available for application will contribute to the effectiveness and safety of the treatment.
Gene Delivery To Triple-Negative Breast Cancer Cells By Folic Acid-Polyethyleneimine Polyplexes
Authors: DEMİR DORA Devrim
Published: October 2023

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and lacks hormonal and growth factor receptors commonly expressed by other types of breast cancer making it difficult to treat by conventional treatments. Although gene therapy might be a therapeutic option, delivery of genes into TNBC cells is still an obstacle. In this study, it was aimed to overcome this obstacle by folic acid (FA) conjugated polyplex formulations to targeting the folate receptor which has been reported to be overexpressed in TNBC cells. Non-covalent complexes of FA and LPEI polyplexes (FA-polyplexes) were prepared at six different ratios. After characterization studies, cytotoxicity and transfection ability were evaluated. Conjugation of FA by increasing amounts of LPEI polyplexes, increased the size from 204.1 to 469.8 nm. Their PDI values were between 0.31-0.51, and zeta potentials were positive. After treatment with polyplex formulations, cell viability was decreased significantly starting from 3:1(w/w) polymer:pDNA ratio and from 3:3:1 (w/w)FA:polyplex ratio. Cell viability decreased below 70% above the 5:1 (w/w) polymer:pDNA ratio. Addition of folic acid to polyplex formulations reversed the cytotoxicity of P3, P4 and P5 formulations. Although LV-RFP pDNA was delivered successfully into 4T1 cells by all formulations, fluorescent microscope images showed that, the optimal formulations were FA-P3 and FA-P4. This gene delivery system, generated by non-covalent conjugation of folic acid to polyplexes, increased the uptake and decreased the cytotoxicity of LPEI polyplexes. Non-covalent complexes of folic acid-LPEI polyplexes represent promising delivery systems in gene therapy, directed against cancer cells expressing folate receptors.