bluuebunny/crossref_metadata_2025 huggingface dataset:
"Is the Mini Nutritional Assessment Short Form (MNA-SF) an Effective Tool for Malnutrition Screening in Parkinson's Disease?" - A Prospective Cross-Sectional Study
Authors: DURMAZ CELİK Nazli , yaman kula Aslı , Çelikeloğlu Elifnur , Toklu Çetinkaya Reyyan , Topal Aydan , Özkan Serhat
Published: January 2025

Background/Objectives: Malnutrition is a frequently observed and essential problem among patients with Parkinson's Disease (PD) that significantly affects their overall health and quality of life. The Mini Nutritional Assessment Short Form (MNA-SF) is a standard tool for screening malnutrition in diverse clinical populations. However, the suitability of MNA-SF to detect nutritional deficiencies in PD patients requires a comprehensive evaluation. In this context, we determined the usefulness of MNA-SF as a tool to identify dietary problems in patients with PD. Methods: Demographic data, disease characteristics, and nutritional characteristics of 42 patients with PD were recorded. Patients were evaluated for malnutrition using clinical scoring. In addition, MNA-SF was applied to each patient, and the results were compared with clinical scores. Results: 22 of 42 patients (or 52.4%) were female, and the mean age of the patients was 59.33±10.19 years. In clinical malnutrition diagnoses, 76.2% of the participants were not malnourished, while the rate of malnourished patients was 23.8%. According to the MNA-SF assessment, 21.4% were malnourished, 38.1% were at risk of malnutrition, and 40.5% showed normal nutrition. The patients who were malnourished had a lower MNA-SF score when compared to the patients who were not malnourished (p =.004). The area under the curve (AUC) is 80.0 percent (CI: 62.1-97.9), effectively distinguishing those malnourished and those not (P=0.005). The sensitivity and specificity were 70.0% and 87.5%, respectively, using a threshold score below 8.5 (CI: 39.7-89.2) (CI: 71.9-95.0). Conclusions: The MNA-SF is a reliable and sufficient tool for identifying malnutrition in individuals with PD. city were 70.0% and 87.5%, respectively, using a threshold score below 8.5 (CI: 39.7-89.2) (CI: 71.9-95.0). Conclusions: The MNA-SF is a reliable and sufficient tool for identifying malnutrition in individuals with PD.
Economic Value Creation of Artificial Intelligence in Supporting Variable Renewable Energy Integration: A Systematic Review of Power System Applications
Authors: Masood Arsalan , Ahmed Ubaid , Hassan Syed Zulqadar , Khan Ahsan Raza , Mahmood Anzar
Published: January 2025

This systematic review aims to elucidate the economic value creation of Artificial Intelligence (AI) in supporting the integration of Variable Renewable Energy (VRE) sources into power systems. Addressing the economic dispatch challenges associated with integrated power system has become paramount due to the increasing penetration of VRE. This paper reviews the role of AI in mitigating costs related to balancing, profile, and grid with a focus on its applications for generation and demand forecasting, market design, demand response, storage solutions, power quality enhancement, and predictive maintenance. By analyzing the use cases across various renewable energy resources (RERs), including wind, solar, geothermal, hydro, ocean, bioenergy, hydrogen, and hybrid systems, this study highlights AI’s potential to enhance economic efficiency and operational reliability. This review spans the literature from 2014 to 2024, offering insights into the advancements and limitations of AI-driven approaches in the renewable energy sector. The findings underscore AI’s critical role in optimizing VRE integration, ultimately facilitating a more resilient and economically sustainable energy landscape.
Understanding the Adoption of Blockchain Technology in Financial Information Systems
Authors: Holloway Samuel
Published: January 2025

This research explores the adoption of blockchain technology in financial information systems, focusing on the motivations, barriers, and potential impacts on financial institutions. As blockchain continues to gain attention for its transformative capabilities, particularly in reducing operational costs, increasing efficiency, and enhancing security, the study investigates the reasons behind its adoption within the financial sector. Through qualitative analysis, the research identifies key drivers for adoption, including cost reduction through the elimination of intermediaries, the enhancement of transaction speed and security, and the ability to foster trust and transparency. Despite these advantages, the research also uncovers significant barriers, such as the integration of blockchain with legacy systems, regulatory uncertainty, technical complexity, and organizational resistance to change. The study also highlights the potential of blockchain to drive financial inclusion by providing underserved populations with access to secure and low-cost financial services. Additionally, the research examines the strategic considerations financial institutions must navigate, including the need for specialized knowledge, leadership support, and the importance of pilot testing before full-scale adoption. Finally, the study suggests that while blockchain adoption faces several challenges, its potential to revolutionize financial information systems is immense, with implications for the future of digital currencies, asset management, and cross-border payments. The research concludes by emphasizing the need for continued investment in blockchain technology and the collaboration between financial institutions, regulators, and fintech companies to realize its full potential.
Object Detection in Low-Visibility Environments
Authors: Oussama Hafi , Samir Khais , Saide Khaid
Published: January 2025

Object detection in low-visibility environments is a critical challenge, particularly for applications like autonomous vehicles and safety monitoring systems. In this work, we explore advanced detection techniques under adverse conditions, leveraging the YOLO11n.pt model for its high performance and real-time capabilities. A com- prehensive review of related works highlights significant progress in the field, such as the use of Visibility Context for robust 3D recognition and thermal imaging for im- proved accuracy during adverse weather. However, these methods often face limi- tations in terms of computational complexity, sensitivity to environmental factors, or reliance on specific hardware. By adopting YOLO11n.pt, we aim to overcome these challenges, providing a solution that maintains high precision and adaptability in dynamic and low-visibility settings. Preliminary results demonstrate the model’s potential in detecting objects accurately even under rain, fog, and poor lighting con- ditions, paving the way for safer and more efficient object recognition systems.
A Comprehensive Examination of Cost Overruns in Road Construction Projects in the Sultanate of Oman
Authors: Yahia Hussin A.M , Al Adawi Osama Salim , Poloju Kiran Kumar , Albrka Ali Shaban Ismael , Mohammed Ali Ahmed , Ali Ahmed Suliman B. , ALLAM Allam Musbah A. L.
Published: January 2025

Project completion on schedule and within budget is always an accomplishment. Several building projects overspent their budgets. Cost overruns in road-building projects are common despite their detrimental impact on the construction sector. This report examines global cost overruns, finds local reasons, assesses and analyses them by relevance, and recommends practical mitigation strategies for top construction parties in Oman, including "clients," "consultants," and "contractors." A comprehensive literature review and local road practitioners helped identify 52 reasons. These theories were explored using a cross-sectional questionnaire given to 85 road specialists, who prioritized the factors by local cost overrun significance. The study found that the top five issues in Oman include contractors not being paid on time, incomplete design at bidding, design defects, cost miscalculation, and financial problems. This survey also found substantial agreement among project partners on the most important causes. SPSS 24.0 and MS Excel were used to examine quantitative data in four phases utilizing the relative significance index, mean value, chi-square test, and bivariate analysis. The pioneering character of this research will benefit road construction management. society because it provides a good starting point for local academics, identifies local road construction management deficiencies, and offers practical mitigation methods to avoid cost overruns. The results imply that project parties must enhance planning, budgeting, engineering design, terrain analysis, and compliance with new rules by using technology effectively.
Characteristics and Performance of Innovative Welding Materials for INCONEL® 690 Alloy
Authors: Semerenko Yuri , Mozgovij Oleksandr , Skibina Liudmyla , Yushchenko Konstantin , Savchenko Viktor , Zviagintseva Ganna , Cherv’yakov Mykola , Volosatov Ivan , Zoryansky Viktor
Published: January 2025

For the first time, the structural-mechanical and acoustic properties of a new promising Filler Metal based on the Ni-Cr-Fe system (INCONEL® 52 and INCONEL® 52MSS) were studied in a wide temperature range of 77-1200 K. Correlations were found in the behaviour of high-temperature acoustic absorption and the temperature range of plasticity failure in INCONEL® 52. It was experimentally established that the availability of more effective pinning centres hindered the dislocation mobility. It creates the preconditions for a more uniform distribution of dislocations, leads to the absence of gradients of local stresses, which in turn provides a high heat resistance and hot cracking resistance of the INCONEL® 52MSS alloy. It has been shown that the acoustic characteristics of alloys of different alloying systems make it possible to establish differences in the tendency to form hot cracks.
Game On: Staff Insights into Gamified Exercise for Long-Term Care Residents Living with Dementia
Authors: Hung Lillian , Lam Jamie , Wong Karen Lok Yi , Wong Joey , Ren Lily Haopu , Chakraborty Nibedita , Zhao Yong
Published: January 2025

Background/Objectives: The aging population presents significant challenges to healthcare systems, with conditions like dementia severely affecting the quality of life for older adults, especially those in long-term care. Gamification has the potential to motivate older adults to engage in exercise by transforming physical activities into enjoyable experiences. Incorporating gaming elements in cycling exercises can foster a sense of interest and achievement, potentially improving health outcomes. This study aims to explore interdisciplinary staff perspectives on using a digital game to motivate cycling exercise among residents living with dementia in long-term care (LTC). Methods: This study applied a qualitative description design. Using an interpretive description approach, we conducted focus groups with 29 staff members, including recreational therapists, rehabilitation therapists, nurses, care aides, and leadership in an LTC home. The consolidated framework for implementation research (CFIR) guided the data analysis to identify barriers and facilitators to adopting the digital game. Results: Engaging LTC residents living with dementia presents various challenges. Identified barriers to implementing the cycling game include cognitive and physical limitations, resistance to change, and intervention complexity. Frontline staff strategies include flexible invitations, social groups, making it fun, and building rapport. Success relies heavily on its cultural and individual relevance, along with strong support from leadership, peers, and family. Conclusions: Integrating gamification in exercise for older adults with dementia in LTC settings shows promise. However, addressing facilitators and barriers identified by staff is required. Successful implementation relies on tailoring interventions to meet residents' specific needs and preferences while addressing the identified challenges to maximize engagement and health benefits. This study adhered to the COREQ Checklist.
Exploring the nutritional value, health benefits and concerns associates in selected fermented fish product in Southeast Asia: A review
Authors: Binti Atun Mazlinah , Binti Julmohammad Norliza , Huda Nurul , Bin Roslan Jumardi , Mohd Shariff Amir Husni , Nisa Fithri Choirun , Yusra
Published: January 2025

Fermented fish is a staple food in Southeast Asian cuisine with a unique flavor and nutritional properties. This paper provides a comprehensive review of fermented fish, its types and methods of fermentation, nutritional value, health benefits, and risks. The paper highlights traditional and modern methods of fermentation using various types of fish and provides examples of popular fermented fish dishes. The nutritional value of fermented fish is emphasized, including their high protein and amino acid content, omega-3 fatty acids, vitamins, and minerals. Moreover, fermented fish has demonstrated promising health benefits such as improved cardiovascular health, gut health, and anti-cancer properties. However, high sodium content and potential risks of histamine poisoning, or other foodborne illnesses require caution in the consumption of these foods. The paper concludes by underscoring the cultural and public health significance of fermented fish and highlighting the potential for further research on the health benefits and risks of this traditional food.
Promoting nasi goreng as Indonesian cultural heritage: Harmony in taste, history and tourism aspects
Authors: Amiruddin Achmad , Adi Prakoso , Mulyani Rizka , Chi-Ming Hsieh , Hidayat Serli Hatul
Published: January 2025

Culinary diversity, such as nasi goreng, which is easily found both at street food to luxury restaurants in Indonesia, is the most popular thing for foreign tourists. The development of nasi goreng over time has solidified its status as a globally recognized cultural and national identity of Indonesia. Recently, nasi goreng stands as a national dish, rivaling and surpassing other international delicacies in popularity and flavor. However, there is a pressing need to promote the unique characteristics of Indonesian nasi goreng globally to enhance the international appeal and boost regional tourism potential. This review aims to delve into the history, diversity and uniqueness of Indonesian nasi goreng, examining the role in enhancing local tourism and promoting Indonesia’s cultural heritage. Our study showed that although nasi goreng is served in the same way, each nasi goreng in Indonesia has unique characteristics depending on the characteristics of the region. The variation in complementary ingredients across different regions contributes to Indonesia’s rich diversity of nasi goreng types. The beauty of tourism is also present in all regions of Indonesia. Promoting Indonesian culinary tourism should expose various traditional Indonesian foods and promote the beauty of tourism from the origin of the food itself. Therefore, exploring the rich history and unique flavors of Indonesian nasi goreng not only highlights the essence of the nation's culinary heritage but also serves as a gateway to promoting Indonesia as a vibrant and enticing tourist destination on the global stage.
Kié a(z irodalmi) város? : Genderkérdések az írott terekben
Authors: Borda Réka
Published: January 2025

A gender által meghatározott terek (gendered spaces) „toposzként” a mai napig jelen vannak az irodalmi művekben. Tanulmányomban a nyilvános (főként városi) és a privát narratív terek viszonyát vizsgálom meg a társadalmi nemek szempontjából. Először témám rövid társadalmi-iroda- lomtörténeti hátterét nyújtom, majd a textualizált genderterek szimbolikus jelentéseit vizsgálom meg, azok trauma-elbeszélői lehetőségeit szemügyre véve. Ezt követően a kognitív narratológia és a feminista narratológia metszéspontjaként az említett toposz tudásgeneráló aspektusát mutatom be a probability design és a 4E kogníció elméletén keresztül, végül pedig kitérek a feminin-maszkulin irodalmi terek tágabb problematikájára a történelmi emlékezet és az irodalmi kánonformálás tükrében. Célom, hogy szintetizáljam az ez idáig keveset taglalt ismereteket az irodalmi genderterekről, valamint hogy rámutassak: nemcsak írói és olvasói, hanem tervezői szempontból, valamint a designkultúra-tudomány oktatását tekintve is szükséges tudatosan megközelíteni a textualizált tereket.
A város mint konkrét utópia: Henri Lefebvre városelméleti munkássága a spekulatív designelmélet kontextusában
Authors: Hulesch Máté
Published: January 2025

„Nem lehetséges a régi várost helyreállítani, kizárólag egy új város létrehozására van lehetőség, új alapokon, más léptékben, más körülmények között, egy másik társadalomban” – állítja Henri Lefebvre eredetileg 1967-ben megjelent, immár magyarul is olvasható, „A városhoz való jog” című esszéjében. (2023, 119) A nagy hatású szöveg gyakori hivatkozási pontja a hajléktalansággal, lakhatással és egyéb, a városi élettel összefüggő társadalmi problémákkal küzdő civil szervezeteknek és aktivista csoportoknak, akik a méltó városi élethez való jog kiáltványaként tekintenek a francia filozófus művére. Bár e megközelítés kétségkívül helytálló, Lefebvre szövegének van egy másik, kissé anakronisztikusan spekulatívnak nevezhető olvasata is: a városhoz való jog Lefebvre számára a teljesen urbanizálódott társadalomhoz való jogot jelenti; egy teljesen új, eljövendő társadalomhoz való tartozás jogát, amely az indusztriális társadalmat követi majd. Vagyis a városhoz való jog értelmezhető úgy, mint a jövőhöz való jog: annak lehetősége, hogy az egyén a társadalom része maradhasson annak teljes urbanizációját követően. Milyen az az urbanizálódott társadalom, amelyet Lefebvre a ’60-as, ’70-es években írt szövegeiben előrevetít? Milyen építészeti víziók állíthatóak ezzel párhuzamba? És mennyire maradt releváns mindez ma, bő fél évszázaddal később? Tanulmányomban e kérdésekből kiindulva igyekszem egy spekulatív olvasatot adni Lefebvre urbanizációról szóló írásainak (1991, 2003, 2023), beemelve azokat a spekulatív építészeti diskurzusba.
Arkhé-tech-túra: A város mint kozmológiai intervenció
Authors: Kulcsár Géza
Published: January 2025

Város és természet, város és vadon dichotómiái mögött a teremtés, a kozmosz alapproblémája húzódik meg – a világ létéhez és az ember világban-létéhez szükséges szeparációk, le- és elhatárolások, illetve materiális és kulturális építési projektumok implementációs, azaz elsősorban morfológiai és topográfiai kérdések. Az ember ittléte egy szférikus kozmoszba ágyazott négyszöges kertből indul, és a tökéletes város kocka alakú terébe tart (melyet, makacs kozmopolitikusságból, mégis oly gyakran körnek festenek egészen az újkor kezdetéig). A kör és a négyzet mint kettős kozmológia alapforma hagyománya (lásd még: a kör négyszögesítése) a zsidó-kereszténység umbilicus mundija, Jeruzsálem kapcsán is megjelenik: a Mennyei Jeruzsálem ikonográfiája ugyanakkor lesz az „interdiszciplináris teológiában” építészeti és társadalomelméleti spekuláció tárgya, amikor az utópia képzetének szigorú platonizmusa átadja a helyét a tökéletes közösség megépíthetőségének, röviden: a modernizmusnak. A történelem jelenleg is tapasztalható állítólagos vége (a közelgő eszkaton?) mintha a visszatérés jegyében állna: a városépítés legkésőbb a hatvanas évek kritikai radikalizmusától kezdve elvirtualizálódik: a Plug-In City (Archigram) vagy a No Stop City (Archizoom) nemigen olvasható másként, mint a várostervezés kozmológiai intervenciójaként. Ez persze összefügg a konvencionális, materiális tervezési-építési-lakozási praxis beavatkozási gyakorlatával, amely a köztér és közjó diskurzusa és térgyakorlata mentén implicite szintén egy tradicionális, héjas kozmológiát tételez, az emberléptékűtől (városi köztér) az istenléptékűig (Föld, világ). A posztmodern kollázsok, spekulatív városvíziók és a technológiai innovációk homogén totalitásában a futurizmusok és posztutópiák egybeesnek az ősvárossal, a platóni-timaioszi khórából, a minőségeket és formát megelőző, archetipikus architektúrából, primordiális világszövetből épült Atlantisszal.
Őry Júlia: „Tisztelt Kollégánk! Közös játékra hívjuk…”: A Keszthely ’81 pályázat a kelet-európai konceptuális városépítészet kontextusában
Authors: Őry Júlia
Published: January 2025

Performatív séták Riga elhanyagolt városrészében, Laurie Anderson-dal ihlette toronyház-sor, egy prágai lakótelep szürreális átváltoztatása – néhány izgalmas munka az Észt Építészeti Múzeum 2023-as, a keleti blokkban született művekre fókuszáló kiállításáról (Forecast and Fantasy. Architecture without Borders, 1960s to 1980s). Itt került először nemzetközi kontextusba Ekler Dezső, Gyarmathy Katalin, Konrád György, Nagy Bálint, Pikler Katalin, Rajk László és társaik 1981-es, Keszthely belvárosának rehabilitálásra benyújtott pályaműve, amely a tallinni bemutató „The City as a Stage” szekcióját vezette fel. A több mint száz, különböző szakmát és generációt képviselő alkotó bevonásával megvalósított koncepció a funkcionalista várostervezés és a tervezővállalati rendszer kritikája. A montázsként összeállított, a település jövőjén a történeti városi szövet vizsgálata alapján gondolkodó terv megjelenésében is figyelemfelkeltő munka lett, amelynek tudományos feldolgozása eddig még nem történt meg.
A Keszthely ’81 pályázat értelmezéséhez, a posztmodern fordulattal való kapcsolatához fogódzót ad az 1980-as első Velencei Építészeti Biennále és az UIA 1981-es varsói kongresszusa. Az építészet kommunikálásának intézményesülésével az ekkor nemzetközi szinten elterjedő „papírépítészet” létjogosultságot nyert. A szakmai folyóiratok nemzetközi ötletpályázatain kelet-európai építészek is indultak, e példákból többet is bemutatott a tallinni kiállítás. Jelen tanulmányban ebből az anyagból, az egykori szocialista országok művészeinek papírépítészeti és performatív munkái közül mutatok be a várost kutató, kollaboratív példákat, részletesebben kitérve a Keszthely ’81 pályázatra, és néhány rövid idézetet is közreadva Konrád publikálatlan, a pályamű alkotóival készített interjúsorozatából.
Budapest, színházi város
Authors: Sirató Ildikó
Published: January 2025

Mi teszi a várost? E „költői kérdésre” számos tudományos és a hétköznapi tapasztalatokon alapuló választ tudunk megfogalmazni. A jelen dolgozatban a kérdést pontosítva, fókuszálva arra keresünk választ, mi teszi a színházi várost. Milyen mennyiségi, illetve minőségi mutatók teljesülése szükséges ahhoz, hogy a lakók és a későbbi elemzők, kutatók egy város színházi életét megfelelőnek, kielégítőnek, vagy akár gazdagnak érezzék és nevezzék?
Vajon titulálhatjuk-e Budapestet színházi városnak? Milyen fizikai és szellemi–kulturális–művészeti kapcsolat jön létre és működik a város mint közösségi léttér és intézményei között? S hogyan írható le egy növekvő és erősödő település esetében a folyamatok dinamikája?
A településtörténet, a kulturális antropológia, a kulturális szociológia és a színháztörténet elméleti és módszertani tapasztalatait most Budapestnek és színházi játszóhelyeinek kapcsolatát vizsgálva kötjük össze, s megkíséreljük fölvázolni azokat a jellemzőket, melyek színháztörténetében a városszerkezet fizikai–építészeti, közigazgatási és művészeti–intézményi struktúráira hatással voltak és vannak.
Bemutatunk néhány történeti példát arra, hol s miképp helyezkedik el, illeszkedik be egy színház a közösségi térbe mint épület és mint közintézmény, miképpen változtatja meg a városszerkezetet, vagy épp hogyan változik meg egy városi (lét)tér, ha eltűnik. Hogyan bővült a várossal együtt a színházi tér a metropolisszá fejlődő Budapesten, s hogyan épül tovább lényegében változatlan megoldásokkal a színházstruktúra? A várostervezés és a közönség körének bővülése, ízlésének változása hogyan alakít ki új centrumokat az újonnan meghódított, beépített területeken, a városlakók szokásainak és igényeinek megváltozása hogyan hat a kereskedelmi és kulturális intézményszerkezetre? Ezek a később kifejtendő összefüggések jól vizsgálhatók a színjáték épített vagy „talált” tereinek történetiségében.
Plan de negocios para la producción y la comercialización de carbón hecho de orujo de manzana en Lima moderna
Authors:   , Leon Cordova Roxana , Ramirez Quiroz Jorge Enrique , Saldaña Fasabi Arnulfo , Suclupe Sanchez Yanina Erika , Tineo Chuquillanqui Hierson Armando
Published: January 2025

Presentamos el siguiente proyecto de investigación que es Biocarbón, Carbón hecho de orujo de manzana es un emprendimiento que se crea para solucionar la problemática que existe por la contaminación ambiental en reemplazo del carbón común que es un agente de alta contaminación. Dicho plan consiste en la creación de la empresa “ECO Bio Carbón S.A.C.”, Conformado por 5 socios SUCLUPE SANCHEZ, YANINA quien será Gerente General, LEON CORDOVA, ROXANA. RAMIREZ QUIROZ, JORGE. ENRIQUE SALDAÑA FASABI, ARNULFO. TINEO CHUQUILLANQUI, HIERSON ARMANDO con una participación del 25% cada uno. Bio carbón se encuentra en el rubro de la industria. La propuesta de valor del proyecto es ofrecer una alternativa al carbón tradicional ante la urgente necesidad de mitigar el daño ambiental, siendo este proyecto una alternativa sostenible. El carbón tradicional es un agente de alta contaminación y se utiliza como combustible en algunos hogares, en restaurantes etc. Por tal razón el carbón hecho de orujo de manzana ingresa con una participación del 5% del mercado de esta manera ayuda a minimizar enfermedades al pulmón y la contaminación ambiental. En el Perú no existe este producto, por tal motivo, se toma como referencia la demanda que tiene el carbón tradicional en la ciudad de lima equivalente a 259,550kg. mensuales mediante la encuesta realizada a nuestro público objetivo obtuvimos en los resultados el 100% de aceptación con un margen de error del 5%. El desarrollo del Carbón hecho de orujo de manzana se enfocará en el canal de distribución directa y serán atendidos mediante páginas digitales como páginas Web, redes sociales y WhatsApp Business, la empresa Shalom Express es la responsable de realizar las entregas...
Plan de negocios para la comercialización de mochilas transportadoras para gatos vía online en Lima metropolitana
Authors:   , Cardenas Huaringa Luz Maria , Crisostomo Nolasco Nayelin Julia , Yauri Caña Diana Madeleine , Valverde Tapiaza Ingrid Katerine
Published: January 2025

El plan de negocios que se plantea “BagCat” surge a partir de considerar el gran crecimiento del mercado relacionado al cuidado y tenencia de mascotas, debido a las tendencias actuales las mascotas se han convertido en los integrantes protagonistas de las familias no solo a nivel nacional sino mundial, por décadas se ha considerado a las mascotas acompañantes del hombre o como comúnmente se les ha denominado “El mejor amigo del hombre”. Según las últimas estadísticas presentadas por Ipsos, en el Perú “aproximadamente el 58% de los hogares tiene una mascota” (2023). Esto demuestra la preferencia y apego de los peruanos hacia los animales domésticos o de compañía; por lo cual la cantidad de clientes ha aumentado, al igual que las exigencias del mercado para con productos novedosos que puedan usar con sus engreídos propiciando un crecimiento potencial en el mercado de mascotas. Según Ballarin, para el año 2019 más de la mitad de los hogares peruanos que contaban con una mascota tenían preferencia sobre los gatos, esto debido al tamaño, tipo de atención y comportamiento de la mascota. Adicionalmente a ello “solo el 40% de los felinos en el mundo realizan una visita rutinaria al veterinario” (Royal, 2023). Ello se debe al tipo de transporte que se utilizan y la inseguridad que les causa. Por lo cual, el presente proyecto proyecta el uso de estrategias claves para la estructuración, lanzamiento y crecimiento de la empresa BagCat en el mercado de mochilas transportadoras, utilizando distintas herramientas estratégicas de evaluación, así como el análisis exhaustivo del entorno. Se proporciona una guía…
Ausentismo laboral y costos generados por los descansos médicos otorgados en el año 2017 a los trabajadores de «JRC Ingeniería y Construcción S.A.C.» que prestan servicios a la «Sociedad Minera El Brocal S.A.A»
Authors:   , Fernandez Vargas Machuca Nancy Rogelia
Published: January 2025

Presentamos la investigación intitulada “Ausentismo Laboral y costos generados por los Descansos Médicos otorgados en el año 2017 a los trabajadores de «JRC Ingeniería y Construcción S.A.C.» que prestan servicios a la «Sociedad Minera el Brocal S.A.A.»”. En dicha tesis tipo observacional, descriptiva, retrospectiva, como objetivos: Determinar el índice de absentismo laboral en los trabajadores de «JRC Ingeniería y Construcción S.A.C.» que prestaron servicios a la «Sociedad Minera El Brocal S.A.A.» en el año 2017; y, estimar los costos generados por los descansos médicos otorgados a dichos trabajadores. Luego de realizar el análisis de contenido de los reportes de descansos médicos otorgados en el año 2017 a los trabajadores en cuestión, se llegó a las siguientes conclusiones: el índice de absentismo laboral en los trabajadores antes mencionados en el año 2017 fue de 1,6%; los costos generados por los descansos médicos otorgados, 693 trabajadores quienes acumularon un total de 3 842 días de trabajo perdido durante el año 2017, ascendieron a un total de S/ 5 810 394; y, no hubo tardanzas reportadas por los trabajadores ya que, el régimen laboral 14/7 exige la permanencia de los trabajadores dentro de campamento los días laborables.
Leveraging Survival Analysis and Machine Learning for Accurate Prediction of Breast Cancer Recurrence and Metastasis
Authors: Noman Shahd M. , Fadel Youssef M. , Attia Nada A. , Tarek Mayar , Essam Malak , ElMasarawi Sarah , A.Fouad Fayrouz , G.Eltasawi Esraa , Al-Atabany Walid
Published: January 2025

Breast cancer, with its high incidence and mortality globally, necessitates early prediction of local and distant recurrence toimprove treatment outcomes. This study develops and validates predictive models for breast cancer recurrence and metastasisusing Recurrence-Free Survival Analysis (RFS) and machine learning techniques. We merged datasets from the MolecularTaxonomy of Breast Cancer International Consortium (METABRIC), Memorial Sloan Kettering Cancer Center (MSK), DukeUniversity, and the SEER program, creating a comprehensive dataset of 190,789 rows and 23 columns. Our methodologyutilized three predictive strategies: assessing recurrence risk, differentiating local from distant recurrences, and identifyingpotential metastatic sites. Key prognostic factors were identified through survival analysis. LightGBM, XGBoost, and RandomForest models were employed and validated against data from the Baheya Foundation. The models demonstrated strongperformance; the survival analysis achieved a C-index of 0.837. The LightGBM model reached an AUC of 92% in predictingrecurrences, while XGBoost and Random Forest models distinguished recurrence types with up to 86% accuracy and predictedspecific metastatic sites effectively. This study highlights the significant potential of machine learning in advancing breastcancer management and sets a new benchmark for predictive analytics. Future research will integrate genetic data to furtherenhance these models.
Physiological Sources of Essential Lipids for Mycoplasma pneumoniae via Protein P116: Innovative Biotechnological Tools for Targeting Atherosclerotic and Hepatic Lesions
Authors: Escola-Gil Joan Carles , Vizarraga David , Marcos-Silva Marina , Rotllan Noemi , Martín Jesús , Santos David , Camacho Mercedes , Guerra Pablo , Pareja Félix , Collantes María , Wu Wanlu , Rodriguez-Arce Irene , Serrano Luis , Piñol Jaume , Fita Ignacio
Published: January 2025

Mycoplasma pneumoniae (MPN) is a bacterial pathogen in humans that primarily causes atypical pneumonia. MPN cannot synthesize several lipids crucial for its cell membrane structure and needs to extract them from the lung of the host to survive. The protein responsible for extracting essential lipids from cell membranes is P116. MPN has been detected in increased quantities within ruptured atherosclerotic plaques and the question is how MPN survives in the blood and in the plaques and obtains the lipids necessary for its membrane. Here we show that P116 can uptake essential lipids from LDL and HDL and when targeting its C-terminal domain via a monoclonal antibody there is growth inhibition in vitro. Phase contrast epifluorescence microscopy of human arteries also revealed that this antibody blocks MPN binding to human atherosclerotic lesions ex vivo. Furthermore, injection of MPN in the blood results in accumulation of MPN within the liver and atheroma plaques in a hyperlipidemic mouse model. We conclude that P116 plays a critical role in extracting essential lipids from physiological circulating lipoproteins and from host cells and regulates MPN localization to liver and atheromatous plaques. These results suggest new strategies for managing mycoplasma infections and addressing the potential complications of MPN infections in atherosclerotic lesions. They also open avenues for utilizing biotechnological tools in the treatment of atherosclerotic and hepatic lesions.
Patient specific seizure prediction for time intervals using TQWT and deep learning
Authors: Jo YongUn , Oh Do Chang
Published: January 2025

Seizures are sudden activations of part or all of the brain, which are the primary symptoms of epilepsy. Epileptic seizures are characterized by their sudden and unpredictable nature and pose significant risks to patients’ daily lives. In many patients with epilepsy, specific symptoms are observed for a short period before a seizure occurs. Research is ongoing to develop technology that can predict seizures by detecting these symptomatic signals. In this paper, we used the CHB-MIT database, which contains more than 150 seizures in approximately 1,000 hours of EEG data collected from 23 children with intractable seizures. Tunable Q-factor Wavelet Transform (TQWT), a specific type of wavelet transform, was applied to the data to predict seizures by identifying inter-ictal and pre-ictal states using a relatively simple deep learning classifier. Each classification was performed individually for each patient, and seizure prediction during a specific period was achieved using k-fold cross-validation, a technique commonly employed in deep learning. By combining the results, the period with the highest probability of seizure occurrence for each patient was designated the specific warning period. Ultimately, it was possible to predict seizures 15 minutes in advance, achieving an average sensitivity of 0.97, an F1 score of 0.90, and a false discovery rate (FDR) of 0.13 for all patients. Additionally, a specific warning period was established for each patient, ranging from a minimum of 2.5 minutes to a maximum of 15 minutes. .
The Association between High-Density Lipoprotein Cholesterol and Diabetic Retinopathy : A Cross-Sectional Study in patients with type 2 diabetic mellitus
Authors: ling Juan , Xie Zhuo-Lin , Luo XiangXia , Chen xingLin , Gao Ying , zhuang jiayuan
Published: January 2025

Background
Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus and a leading cause of visual impairment. While dyslipidemia has been implicated in DR pathogenesis, the relationship between high-density lipoprotein cholesterol (HDL-C) and DR remains controversial. This study aimed to investigate the association between HDL-C levels and DR prevalence in patients with type 2 diabetes mellitus (T2DM).
Methods
A total of 2001 (858 men and 1143 women) patients with T2DM who visited the diabetic clinic in the Internal Medicine out-patient departments of two hospitals in southern Taiwan between April 2002 and November 2004. Demographic and clinical data were collected, and serum HDL-C levels were measured. The association between HDL-C and DR was analyzed using multivariate logistic regression, adjusting for potential confounders and the potential non-line correlation was explored with smooth curve fitting approach.
Results
Among the 2001 participants, 701 (35.0%) were diagnosed with DR. Our findings revealed a significant inverse linear relationship between HDL-C levels and the risk of DR, with an odds ratio of 0.91 (95% confidence interval: 0.84 to 0.98, p = 0.0327). This suggests that higher HDL-C levels are associated with a reduced risk of developing DR. In the subgroup analysis, the linear correlation between HDL-C and DR was also found in female, different age stage and different DBP stage.
Conclusions
This study provides a linear relationship evidence that elevated HDL-C levels are associated with a decreased risk of DR in patients with T2DM. Future research should further explore the mechanisms underlying this association and its implications for therapeutic strategies.
Antibiotic Resistance Profile of Wound Infection Isolates: High Resistance to Cephalosporins and Penicillin Among Ghanaian Patients
Authors: Kwashie Nelson , Antwi-Baffour Samuel , Anniston Lawrence , Appah Ofosual L. , Paul Uwakmfon , Akpobi Solomon , Senu Ebenezer
Published: January 2025

Background and Aim:
Antibiotics constitute one of the most routinely used medications in clinical settings. However, antimicrobial resistance (AMR) is inevitable and irreversible natural consequence of bacterial cell adaptation to exposure of antimicrobials. Conversely, there is limited study on antibiotic resistance pattern of bacteria isolated from infected wounds. This study assessed the prevalence and magnitude of antibiotic resistance pattern of bacteria isolated from infected wounds among Ghanaians.
Methods
This experimental cross-sectional study included 300 patients with suspected wound infections receiving treatment at MDS – Lancet Laboratories. Wound swabs were taken and inoculated on basic media, incubated at 37 degrees Celsius for 18 to 24 hours for the first reading and re-incubated again overnight for the second reading. Identification of isolates was based on morphological characteristics, grams stain reactions, biochemical reactions and using API 20 E/NE. Susceptibility testing was done using disc diffusion method. Statistical analyses were done using SPSS version 26.0 and GraphPad 8.0
Results
The most isolated organisms causing wound infections were Escherichia coli (23.2%), Pseudomonas aeruginosa (19.8%), Klebsiella spp. (19.2%) and Staphylococcus aureus (15.2%). Susceptibility outcome revealed that aminoglycoside (Amikacin, and Gentamicin), carbapenem (Ertapenem, Imipenem, and Meropenem) and tetracycline (Tigecycline) were most effective antibiotic against Gram negative bacteria in wound infections whilst 2nd, 3rd and 4th generation cephalosporin (Cefuroxime, Ceftriaxone and Cefepime respectively), and aminopenicillin (Amoxicillin) had the highest resistant. Moreover, Gram positive bacteria such as Staphylococcus aureus and Coagulase negative Staphylococcus aureus (CNS) were most susceptible to aminoglycosides (Gentamicin), lincosamides (Clindamycin) and macrolides (Erythromycin), however had highest resistant against 1st and 2nd generation cephalosporin (Cefazolin and Cefoxitin respectively), penicillin (Augmentin and Cloxacillin) and Tetracycline. Prevalence of ESBL producing organisms isolated was 30.3% and were majorily Escherichia coli (50.0%) and Klebsiella spp (43.9%). Prevalence of MRSA organisms was 34.7%, and methicillin-resistant coagulase negative Staphylococcus aureus (MRCNS) was 66.7%.
Conclusion
Aminoglycosides and Linezolid are most effective against Gram positive and Gram-negative bacteria causing wound infections. However, both Gram positive and Gram-negative bacteria are resistant to 2nd generation cephalosporins and penicillin. Treatment of wound infections has to be done based on the culture and susceptibility test results.
Molecular dynamics simulation of the mechanical properties of silicone sealants
Authors: Qi Wen , Du Yu-Fei , An Gui-lei
Published: January 2025

Silicone sealant as a room temperature crosslinking curing silicone polymer material is widely used in curtain wall and prefabricated buildings, the study of the relationship between the crosslinking molecular structure of silicone sealant and its properties is of great significance to improve the mechanical properties of silicone sealant and to design or develop new types of silicone sealant products.Three mixed system models of crosslinking silicone sealant/plasticizer are constructed by molecular dynamics simulation method, and the effect of three influencing factors, namely, crosslinking degree of silicone sealant, plasticizer content and external temperature on the mechanical properties of silicone sealant system are analyzed.The results show that at room temperature, the mechanical properties of silicone sealant system is enhanced with the increase of its crosslinking degree; At high crosslinking degree, with the increase of plasticizer content, the mechanical properties of silicone sealant system is an overall decreasing trend.When the methyl silicone oil in the range of 20%, the mechanical properties of the silicone sealant appeared to be a small degree of enhancement;As the temperature increases, the doped white oil mechanical properties of silicone sealant declined significantly, while doped with mthyl silicone oil silicone sealant and doped with double-ended vinyl silicone oil silicone sealant mechanical properties have better heat resistance.
Synthesis, Characterization and Surface Analysis of Intermolecular Interactions in a Supramolecula Hybrid Inorganic-Organic Polymer Complex Featuring Hydrogen Bonding, Halogen Bonding, and π-π Interactions
Authors: Mirtamizdoust Babak , Karamad Amirhossein , Mojtabazade Faeze , Hoseini-monfared Hasan , Bikas Rahman
Published: January 2025

This research details the successful creation and analysis of a polymer complex with the formula [Cu(µ-Cl)(µ-OCH3)(2-apy)]n CH3OH. The complex was produced by combining 2-apy and copper chloride in a 1:1 ratio using methanol as the solvent. Characterization of the resulting polymer complex was conducted through X-Ray diffraction and verified by IR spectroscopy. Crystallographic data indicated that the polymer crystallizes in a triclinic crystal system, specifically within the Pī space group. The coordination environment around each copper atom forms a square-based pyramid, where the nitrogen of the 2-amino-pyrimidine ligand (2-apy), one chlorine, and two oxygen atoms from bridged methoxy groups form the pyramid's base. The compound showcased intermolecular hydrogen bonding, halogen bonding, and π-π interactions within the coordination polymer. Hirshfeld surface analysis revealed the compound's contributions as 18.1% for hydrogen bonds, a significant 16.6% for halogen bonds, and 48.5% for hydrogen-hydrogen interactions. This study offers valuable insights into the synthesis, characterization, and properties of polymer complexes.
Association between HIV infection and erectile dysfunction: A two-sample mendelian randomization study
Authors: Jiang Tiancheng , Wang Ganlin , Jiang Yinfeng , Chen Shuqiu , Zhang Zhenglin
Published: January 2025

Objectives
The aim of this study was to investigate whether there is a causal relationship between HIV infection and erectile dysfunction in men through Mendelian randomization analysis.
Materials and methods
Two-sample Mendelian randomization (MR) analyses were performed using publicly available genome-wide association study (GWAS) statistics. The inverse variance weighting (IVW) method was used as the primary analysis. We applied complementary methods including MR-Egger regression, simple mode, weighted mode, and weighted median as corrections and supplements. Sensitivity analyses such as heterogeneity test, pleiotropy test, and leave-one-out analysis were also performed to assess the bias of the study.
Results
IVW MR analysis showed no effect of HIV infection on ED (IVW OR = 1.058, P = 0.462).The results of the MR-Egger regression, simple model, weighted model, and weighted median methods were consistent with those of the IVW method (P>0.1). Based on sensitivity analyses, horizontal pleiotropy was unlikely to distort causal estimates, although some heterogeneity existed.
Conclusion
Although observational studies have reported an association between HIV infection and erectile dysfunction, the results of our MR analysis do not support a causal relationship between HIV infection and erectile dysfunction.
Magnesium promotes implant osseointegration by regulating LepR + stem cells
Authors: Liu Linfeng , Huang Lixuan , Song Wei , Zhang Danting , Zhang Shiwen , Yang Fan
Published: January 2025

Background
Homing and differentiation of stem cells is a necessary step in achieving implant osseointegration. However, the specific role and mechanism about stem cells in the osseointegration process were rarely reported. Rencently, LepR+ cells were identified as crucial skeletal stem cells in the long bone and alveolar bone, which participated homeostasis maintenance and damage repair. As one of the indispensable trace elements in the human body, Mg2+ were proved to promote vascularized bone regeneration. Here, by combining tissue clearing technique and immunofluorescent mice, we proved that Mg2+ promoted implant osseointegration by regulating LepR+ stem cells aggregation and differentiation at the implant-bone interface in vivo and provided a new perspective to promote the study of implant research.
Purpose
The aim of the study was to explore the effects of Mg2+ in promoting implant osseointegration in the alveolar bone.
Methods
The cell proliferation and osteogenic differentiation were performed to screening the optimal Mg2+ concentration for MC3T3-E1 osteoblasts. Then the optimal Mg2+ was loaded on a self-designed SLA implant hydrothermally. Characterization and bio-compatibility of materials were detected. In vivo, combining the PEGASOS with LepR-Cre;tdTomato;Col2.3-GFP mice, we traced the LepR positive ( LepR+ ) stem cells aggregation and differentiation at the implant-bone interface.
Results
5mM Mg2+ was screened to be the optimal concentration for MC3T3-E1 osteoblasts. EDS and XRF proved that Mg2+ was successfully corroborated onto the implants. Further detection confirmed the better stretching and proliferatio of Mg-coating implants. 3-D imaging revealed that Mg-coating implants facilitated LepR+ cells aggregation and differentiation to Col2.3-GFP+ cells.
Conclusion
Mg2+ promoted osseointegration around implants by facilitating the LepR+ cells accumulation and osteogenic differentiation.
Beyond the BRCA1/2 genes in ovarian cancer: the clinical and prognostic role of germline pathogenic variants in the ATM gene
Authors: Guadagnolo Daniele , Minucci Angelo , Chiavassa Antonella , Gentile Gabriella , Salvatori Francesca , Hashemian Nader Khaleghi , Maneri Giulia , Piane Maria , Grotta Simona , Grammatico Paola , Pizzuti Antonio , Santini Daniele , De Marchis Laura
Published: January 2025

Ovarian Cancer (OC) prevention and early-stage detection represents a challenge due to the lack of effective surveillance. The identification of high-risk women is crucial as it provides access to prophylactic oophorectomy and reduces disease burden. Next-Generation Sequencing approaches enable the investigation of several genes associated with monogenic hereditary cancer predisposition, including ovarian cancer. For family members of patients affected by ovarian cancer without identification of a germline pathogenic variant, despite the increased empirical risk (3 times) of ovarian cancer incidence, prophylactic surgery is not indicated but may be suggested as the only efficient strategy. Carriers of heterozygous pathogenic variants in the ATM gene have an increased risk of neoplasms incidence, mostly breast but also of OC with an absolute estimated risk of 2–3 times greater than the general population. For these patients there is not well-established evidence of benefit in risk reducing bilateral salpingo-oophorectomy. We hereby present 2 cases of OC: the first in the contest of Hereditary Breast and Ovarian Cancer (HBOC) family history and, in the other one, a late onset of neoplasms, to underline the importance of defining guidelines and management of moderate penetrance genes variants also for ovarian cancer prevention.