bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of dietary intervention on diabetic nephropathy: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials
Authors: Cai Linli , Huang Yin , Li Xingyuan , Cao Dehong , Liu Fang
Published: April 2024

Objective

To evaluate the quality of evidence, potential biases, and validity of all available studies on dietary intervention and diabetic nephropathy (DN).

Methods

We conducted an umbrella review of existing meta-analyses of randomized controlled trials (RCTs) that focused on the effects of dietary intervention on DN incidence. The literature was searched via PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews. According to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE), evidence of each outcome was evaluated and graded as “high”, “moderate”, “low” or “very low” quality to draw conclusions. Additionally, we classified evidence of outcomes into 4 categories.

Results

We identified 36 meta-analyses of RCTs and 55 clinical outcomes of DN from 395 unique articles. Moderate-quality evidence suggested that probiotic supplementation could significantly improve blood urea nitrogen (BUN), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in DN patients. Low-quality evidence indicated that probiotic supplementation significantly improved the serum creatinine concentration, urinary albumin–creatinine ratio (UACR), fasting blood glucose (FBG), HbA1c and high-density lipoprotein cholesterol (HDL-C) in DN patients. In addition, low-quality evidence suggested that a salt restriction diet could significantly improve the creatinine clearance rate (CrCl) in patients with DN. Low-quality evidence suggested that vitamin D supplementation could significantly improve the UACR in patients with DN. In addition, low-quality evidence has indicated that soy isoflavone supplementation could significantly improve BUN, FBG, total cholesterol (TC), triglyceride (TG) and LDL-C levels in patients with DN. Furthermore, low-quality evidence suggested that coenzyme Q10 supplementation could significantly improve HbA1c, TC and HDL-C in patients with DN, and dietary polyphenols also significantly improved HbA1c in patients with DN. Finally, low-quality evidence suggested that supplementation with antioxidant vitamins could significantly improve the serum creatinine concentration, systolic blood pressure, and HbA1c level in patients with DN. Given the small sample size, all significantly associated outcomes were evaluated as class IV evidence.

Conclusion

Moderate to low amounts of evidence suggest that supplementation with probiotics, vitamin D, soy isoflavones, coenzyme Q10, dietary polyphenols, antioxidant vitamins, or salt-restricted diets may significantly improve clinical outcomes in patients with DN.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024512670.
Wind farm site selection using GIS-based mathematical modeling and fuzzy logic tools: a case study of Burundi
Authors: Placide Gatoto , Lollchund Michel Roddy
Published: April 2024

Introduction: The electricity generated from nuclear plants and petroleum-based products has a negative influence on the environment as a whole. It has shown the utility to search out and promote the utilization of renewable, environmentally friendly, and sustainable energy sources such as solar, wind, and geothermal. Nowadays, Wind energy resource has quickly emerged as the world’s fastest-growing energy source.

Methods: However, the selection of the most suitable places for developing a wind farm is a crucial challenge that can be seen as a problem of site selection, which involves numerous conflicting variables. Therefore, it is classified as an MCDM (multi-criteria decision-making) problem. The main objective of this research is to determine the best locations in Burundi for the installation of wind farms. The Fuzzy Analytic Hierarchy Process (FAHP) was used to weigh the criteria considering their relative importance. This study considers several key factors when determining the optimal location for a wind farm. These factors include wind speed, slope, proximity to the grid network, distance to roads, and land use/land cover (LULC). Furthermore, a geographic information system (GIS) is utilized to generate the final suitability wind farm locations map.

Results and Discussion: The obtained results indicate that 20.91% of the whole study area is suitable nevertheless, only 1.96% is tremendously suitable for wind turbine placement. The western part of Burundi is the optimal area for constructing a wind farm, and the most is in Lake Tanganyika.
Morpho-physiological adaptations to drought stress in nitrogen-fixing and non-nitrogen-fixing plants
Authors: Zhao Dongmin , Wei Maohong , Wang Xiaoting , Aqeel Muhammad , Ran Jinzhi , Deng Jianming
Published: April 2024

Drought profoundly affects the morpho-physiological responses of desert plants in dryland. To scrutinize the morpho-physiological responses of nitrogen (N)-fixing legumes (Ammopiptanthus mongolicus, Caragana korshinskii), N-fixing non-legumes (Elaeagnus angustifolia, Hippophae rhamnoides), and non-N-fixing plants (Nitraria tangutorum, Haloxylon ammodendron) under varied drought stress levels (75%, 50%, 25% and 5% of soil water holding capacity), a pot experiment was conducted in greenhouse. Following prolonged water deficit, carbon (C) and N stoichiometry, metabolic rates, plant growth, and biomass distribution of unstressed and stressed plants were recorded. Intensified drought significantly reduced stem, root and whole-plant biomass, with no significant changes observed in leaf dry-fresh mass ratio, specific leaf area, intrinsic water use efficiency and root to shoot ratio. However, other traits were impacted differently, reflecting distinct adaptive strategies to drought among three plant functional types (PFTs). Patterns of trait-soil water content (SWC) relationships varied across different PFTs, with N-fixing non-legumes followed by N-fixing legumes displayed greater sensitivity to SWC variations than non-N-fixing plants. This resulted in a shift from a stronger trait-SWC relationship in N-fixing non-legumes and N-fixing legumes to a less correlated relationship in non-N-fixing plants. The diverse responses to drought among PFTs suggest a shift from N limitation to water limitation as SWC decreases.
Myeloperoxidase induces monocyte migration and activation after acute myocardial infarction
Authors: Peters Vera B.M. , Matheis Friederike , Erdmann Immanuel , Nemade Harshal N. , Muders David , Toubartz Martin , Torun Merve , Mehrkens Dennis , Geißen Simon , Nettersheim Felix Sebastian , Picard Felix , Guthoff Henning , Hof Alexander , Arkenberg Per , Arand Birgit , Klinke Anna , Rudolph Volker , Hansen Hinrich Peter , Bachurski Daniel , Adam Matti , Hoyer Friedrich Felix , Winkels Holger , Baldus Stephan , Mollenhauer Martin
Published: April 2024

Introduction

Myocardial infarction (MI) is a significant contributor to morbidity and mortality worldwide. Many individuals who survive the acute event continue to experience heart failure (HF), with inflammatory and healing processes post-MI playing a pivotal role. Polymorphonuclear neutrophils (PMN) and monocytes infiltrate the infarcted area, where PMN release high amounts of the heme enzyme myeloperoxidase (MPO). MPO has numerous inflammatory properties and MPO plasma levels are correlated with prognosis and severity of MI. While studies have focused on MPO inhibition and controlling PMN infiltration into the infarcted tissue, less is known on MPO’s role in monocyte function.

Methods and results

Here, we combined human data with mouse and cell studies to examine the role of MPO on monocyte activation and migration. We revealed a correlation between plasma MPO levels and monocyte activation in a patient study. Using a mouse model of MI, we demonstrated that MPO deficiency led to an increase in splenic monocytes and a decrease in cardiac monocytes compared to wildtype mice (WT). In vitro studies further showed that MPO induces monocyte migration, with upregulation of the chemokine receptor CCR2 and upregulation of inflammatory pathways identified as underlying mechanisms.

Conclusion

Taken together, we identify MPO as a pro-inflammatory mediator of splenic monocyte recruitment and activation post-MI and provide mechanistic insight for novel therapeutic strategies after ischemic injury.
Heterogeneity of macrophage activation syndrome and treatment progression
Authors: Dong Yuanji , Wang Ting , Wu Huaxiang
Published: April 2024

Macrophage activation syndrome (MAS) is a rare complication of autoimmune inflammatory rheumatic diseases (AIIRD) characterized by a progressive and life-threatening condition with features including cytokine storm and hemophagocytosis. Predisposing factors are typically associated with microbial infections, genetic factors (distinct from typical genetically related hemophagocytic lymphohistiocytosis (HLH)), and inappropriate immune system overactivation. Clinical features include unremitting fever, generalized rash, hepatosplenomegaly, lymphadenopathy, anemia, worsening liver function, and neurological involvement. MAS can occur in various AIIRDs, including but not limited to systemic juvenile idiopathic arthritis (sJIA), adult-onset Still’s disease (AOSD), systemic lupus erythematosus (SLE), Kawasaki disease (KD), juvenile dermatomyositis (JDM), rheumatoid arthritis (RA), and Sjögren’s syndrome (SS), etc. Although progress has been made in understanding the pathogenesis and treatment of MAS, it is important to recognize the differences between different diseases and the various treatment options available. This article summarizes the cell types and cytokines involved in MAS-related diseases, the heterogeneity, and treatment options, while also comparing it to genetically related HLH.
Prediction of storm surge in the Pearl River Estuary based on data-driven model
Authors: Tian Qingqing , Luo Wei , Tian Yu , Gao Hang , Guo Lei , Jiang Yunzhong
Published: April 2024

Storm surges, a significant coastal hazard, cause substantial damage to both property and lives. Precise and efficient storm surge models are crucial for long-term risk assessment and guiding emergency management decisions. While high-fidelity dynamic models offer accurate predictions, their computational costs are substantial. Hence, recent efforts focus on developing data-driven storm surge surrogate models. This study focuses on the Pearl River Estuary in Guangdong Province. Initially, the dynamic ADvanced CIRCulation (ADCIRC) model was utilized to construct storm surge data for 16 historical typhoons, serving as training, validation, and testing data for data-driven models. Subsequently, Long Short-Term Memory (LSTM), Convolutional Neural Networks (CNN), and Informer deep learning (DL) models were employed for forecasting of storm surge over the next 1h, 3h, 6h, 12h, and 18h. Finally, Shapley Additive exPlanations (SHAP) values were used for interpretability analysis of the input factors across different models. Results indicated that the proposed DL storm surge prediction model can effectively replicate the dynamic model’s simulation results in short-term forecasts, significantly reducing computational costs. This model offers valuable scientific assistance for future coastal storm surge forecasts in the Greater Bay Area.
Isolation and characterization of Stenotrophomonas pavanii GXUN74707 with efficient flocculation performance and application in wastewater treatment
Authors: Qin Siqi , Li Qiao , Dou Jin , Man Yuanyuan , Wu Liuyan , Tian Hongmei , Jiang Mingguo , Liu Guofang
Published: April 2024

The identification of microorganisms with excellent flocculants-producing capability and optimization of the fermentation process are necessary for the wide-scale application of bioflocculants. Therefore, we isolated and identified a highly efficient flocculation performance strain of Stenotrophomonas pavanii GXUN74707 from the sludge. The optimal fermentation and flocculation conditions of strain S. pavanii GXUN74707 was in fermentation medium with glucose and urea as the carbon and nitrogen sources, respectively, at pH 7.0 for 36 h, which treatment of kaolin suspension with 0.5 mL of the fermentation broth resulted in a flocculation rate of 99.0%. The bioflocculant synthesized by strain S. pavanii GXUN74707 was found mainly in the supernatant of the fermentation broth. Chemical analysis revealed that the pure bioflocculant consisted of 79.70% carbohydrates and 14.38% proteins. The monosaccharide components of MBF-GXUN74707 are mainly mannose (5.96 μg/mg), galactose (1.86 μg/mg), and glucose (1.73 μg/mg). Infrared spectrometric analysis showed the presence of carboxyl (COO-), hydroxyl (-OH) groups. The SEM images showed clumps of rod-shaped bacteria with adhesion of extracellular products. Furthermore, the strain decolored dye wastewater containing direct black, direct blue, and Congo red by 89.2%, 95.1%, 94.1%, respectively. The chemical oxygen demand (COD) and biological oxygen demand (BOD) removal rates after treatment of aquaculture wastewater with the fermentation broth were 68% and 23%, respectively. This study is the first to report the performance and application of strain Stenotrophomonas pavanii in wastewater flocculation. The results indicate that strain S. pavanii is a good candidate for the production novel bioflocculants and demonstrates its potential industrial practicality in biotechnology processes.
Ultrastructural insights into cellular organization, energy storage and ribosomal dynamics of an ammonia-oxidizing archaeon from oligotrophic oceans
Authors: Zhou Yangkai , Yan An , Yang Jiawen , He Wei , Guo Shuai , Li Yifan , Wu Jing , Dai Yanchao , Pan Xijiang , Cui Dongyu , Pereira Olivier , Teng Wenkai , Bi Ran , Chen Songze , Fan Lu , Wang Peiyi , Liao Yan , Qin Wei , Sui Sen-Fang , Zhu Yuanqing , Zhang Chuanlun , Liu Zheng
Published: April 2024

Introduction

Nitrososphaeria, formerly known as Thaumarchaeota, constitute a diverse and widespread group of ammonia-oxidizing archaea (AOA) inhabiting ubiquitously in marine and terrestrial environments, playing a pivotal role in global nitrogen cycling. Despite their importance in Earth’s ecosystems, the cellular organization of AOA remains largely unexplored, leading to a significant unanswered question of how the machinery of these organisms underpins metabolic functions.

Methods

In this study, we combined spherical-chromatic-aberration-corrected cryo-electron tomography (cryo-ET), scanning transmission electron microscopy (STEM), and energy dispersive X-ray spectroscopy (EDS) to unveil the cellular organization and elemental composition of Nitrosopumilus maritimus SCM1, a representative member of marine Nitrososphaeria.

Results and Discussion

Our tomograms show the native ultrastructural morphology of SCM1 and one to several dense storage granules in the cytoplasm. STEM-EDS analysis identifies two types of storage granules: one type is possibly composed of polyphosphate and the other polyhydroxyalkanoate. With precise measurements using cryo-ET, we observed low quantity and density of ribosomes in SCM1 cells, which are in alignment with the documented slow growth of AOA in laboratory cultures. Collectively, these findings provide visual evidence supporting the resilience of AOA in the vast oligotrophic marine environment.
Genome-based surveillance reveals cross-transmission of MRSA ST59 between humans and retail livestock products in Hanzhong, China
Authors: Zhang Wei , Wang Xueshuo , Zhao Linna , Gu Yihai , Chen Yiwen , Liu Na , An Lin , Bai Li , Chen Yanjiong , Cui Shenghui
Published: April 2024

Methicillin-resistant Staphylococcus aureus (MRSA) has been recognized in hospitals, community and livestock animals and the epidemiology of MRSA is undergoing a major evolution among humans and animals in the last decade. This study investigated the prevalence of MRSA isolates from ground pork, retail whole chicken, and patient samples in Hanzhong, China. The further characterization was performed by antimicrobial susceptibility testing and in-depth genome-based analysis to identify the resistant determinants and their phylogenetic relationship. A total of 93 MRSA isolates were recovered from patients (n = 67) and retail livestock products (n = 26) in Hanzhong, China. 83.9% (78/93) MRSA isolates showed multiple drug resistant phenotype. Three dominant livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) sequence types were identified: ST59-t437 (n = 47), ST9-t899 (n = 10) and ST398 (n = 7). There was a wide variation among sequence types in the distribution of tetracycline-resistance, scn-negative livestock markers and virulence genes. A previous major human MRSA ST59 became the predominant interspecies MRSA sequence type among humans and retail livestock products. A few LA-MRSA isolates from patients and livestock products showed close genetic similarity. The spreading of MRSA ST59 among livestock products deserving special attention and active surveillance should be enacted for the further epidemic spread of MRSA ST59 in China. Data generated from this study will contribute to formulation of new strategies for combating spread of MRSA.
Synchronous excitation in the superficial and deep layers of the medial entorhinal cortex precedes early sharp waves in the neonatal rat hippocampus
Authors: Shipkov Dmitrii , Nasretdinov Azat , Khazipov Roustem , Valeeva Guzel
Published: April 2024

Early Sharp Waves (eSPWs) are the earliest pattern of network activity in the developing hippocampus of neonatal rodents. eSPWs were originally considered to be an immature prototype of adult SPWs, which are spontaneous top-down hippocampal events that are self-generated in the hippocampal circuitry. However, recent studies have shifted this paradigm to a bottom-up model of eSPW genesis, in which eSPWs are primarily driven by the inputs from the layers 2/3 of the medial entorhinal cortex (MEC). A hallmark of the adult SPWs is the relay of information from the CA1 hippocampus to target structures, including deep layers of the EC. Whether and how deep layers of the MEC are activated during eSPWs in the neonates remains elusive. In this study, we investigated activity in layer 5 of the MEC of neonatal rat pups during eSPWs using silicone probe recordings from the MEC and CA1 hippocampus. We found that neurons in deep and superficial layers of the MEC fire synchronously during MEC sharp potentials, and that neuronal firing in both superficial and deep layers of the MEC precedes the activation of CA1 neurons during eSPWs. Thus, the sequence of activation of CA1 hippocampal neurons and deep EC neurons during sharp waves reverses during development, from a lead of deep EC neurons during eSPWs in neonates to a lead of CA1 neurons during adult SPWs. These findings suggest another important difference in the generative mechanisms and possible functional roles of eSPWs compared to adult SPWs.
Neurological manifestations of nontuberculous mycobacteria in adults: case series and review of the literature
Authors: Mina Yair , Kline Ahnika , Manion Maura , Hammoud Dima A. , Wu Tianxia , Hogan Julie , Sereti Irini , Smith Bryan R. , Zerbe Christa S. , Holland Steven M. , Nath Avindra
Published: April 2024

Introduction

Nontuberculous mycobacteria (NTM) mediated infections are important to consider in cases with neuroinflammatory presentations. We aimed to characterize cases of NTM with neurological manifestations at the National Institutes of Health (NIH) Clinical Center and review the relevant literature.

Materials and methods

Between January 1995 and December 2020, six cases were identified. Records were reviewed for demographic, clinical, and radiological characteristics. A MEDLINE search found previously reported cases. Data were extracted, followed by statistical analysis to compare two groups [cases with slow-growing mycobacteria (SGM) vs. those with rapidly growing mycobacteria (RGM)] and evaluate for predictors of survival. NIH cases were evaluated for clinical and radiological characteristics. Cases from the literature were reviewed to determine the differences between SGM and RGM cases and to identify predictors of survival.

Results

Six cases from NIH were identified (age 41 ± 13, 83% male). Five cases were caused by SGM [Mycobacterium avium complex (MAC) n = 4; Mycobacterium haemophilum n = 1] and one due to RGM (Mycobacterium abscessus). Underlying immune disorders were identified only in the SGM cases [genetic (n = 2), HIV (n = 1), sarcoidosis (n = 1), and anti-interferon-gamma antibodies (n = 1)]. All cases were diagnosed using tissue analysis. A literature review found 81 reports on 125 cases (SGM n = 85, RGM n = 38, non-identified n = 2). No immune disorder was reported in 26 cases (21%). Within SGM cases, the most common underlying disease was HIV infection (n = 55, 65%), and seizures and focal lesions were more common. In RGM cases, the most common underlying condition was neurosurgical intervention or implants (55%), and headaches and meningeal signs were common. Tissue-based diagnosis was used more for SGM than RGM (39% vs. 13%, p = 0.04). Survival rates were similar in both groups (48% SGM and 55% in RGM). Factors associated with better survival were a solitary CNS lesion (OR 5.9, p = 0.01) and a diagnosis made by CSF sampling only (OR 9.9, p = 0.04).

Discussion

NTM infections cause diverse neurological manifestations, with some distinctions between SGM and RGM infections. Tissue sampling may be necessary to establish the diagnosis, and an effort should be made to identify an underlying immune disorder.
Msx genes delineate a novel molecular map of the developing cerebellar neuroepithelium
Authors: Gupta Ishita , Yeung Joanna , Rahimi-Balaei Maryam , Wu Sih-Rong , Goldowitz Dan
Published: April 2024

In the early cerebellar primordium, there are two progenitor zones, the ventricular zone (VZ) residing atop the IVth ventricle and the rhombic lip (RL) at the lateral edges of the developing cerebellum. These zones give rise to the several cell types that form the GABAergic and glutamatergic populations of the adult cerebellum, respectively. Recently, an understanding of the molecular compartmentation of these zones has emerged. To add to this knowledge base, we report on the Msx genes, a family of three transcription factors, that are expressed downstream of Bone Morphogenetic Protein (BMP) signaling in these zones. Using fluorescent RNA in situ hybridization, we have characterized the Msx (Msh Homeobox) genes and demonstrated that their spatiotemporal pattern segregates specific regions within the progenitor zones. Msx1 and Msx2 are compartmentalized within the rhombic lip (RL), while Msx3 is localized within the ventricular zone (VZ). The relationship of the Msx genes with an early marker of the glutamatergic lineage, Atoh1, was examined in Atoh1-null mice and it was found that the expression of Msx genes persisted. Importantly, the spatial expression of Msx1 and Msx3 altered in response to the elimination of Atoh1. These results point to the Msx genes as novel early markers of cerebellar progenitor zones and more importantly to an updated view of the molecular parcellation of the RL with respect to the canonical marker of the RL, Atoh1.
Risk factor of postoperative adverse events among children with duplex kidney undergoing upper pole heminephrectomy: a single-center experience
Authors: Wang Denghui , Cui Mengjie , Chu Xiangyang , Han Xiaojiang , Liu Pengpeng , Zhao Xiang , Fan Yingzhong
Published: April 2024

Objective

The aim of this study was to identify the risk factors for postoperative adverse events in children with duplex kidney undergoing upper pole heminephrectomy.

Methods

We collected clinical data from pediatric patients with duplex kidney who underwent upper pole heminephrectomy. Based on the presence or absence of postoperative adverse events, the patients were divided into two groups: an adverse events group (n = 16) and a non- adverse events group (n = 37), using multivariate logistic regression analysis to screen for independent risk factors for postoperative adverse events.

Results

Through univariate and multivariate analysis, we found that the presence of upper renal ureterocele (P = 0.042, OR = 7.116, 95% CI 1.073–47.172), as well as the presence of accessory renal artery type (P = 0.016, OR = 10.639, 95% CI 1.551–72.978) and other types (P = 0.039, OR = 3.644, 95% CI 0.351–37.836) as the upper kidney's blood supply artery increase the risk of postoperative adverse events, with these differences being statistically significant.

Conclusions

In pediatric patients with duplex kidney undergoing upper pole heminephrectomy, the presence of upper renal ureterocele and the presence of accessory renal artery type and other types as the upper kidney's blood supply artery are independent risk factors for postoperative adverse events.
Effects of N application methods on cotton yield and fertilizer N recovery efficiency in salinity fields with drip irrigation under mulch film using 15N tracing technique
Authors: Luo Zhen , Tang Wei , Wang Xiaowen , Lu Hequan , Li Chenyang , Liang Jun , Kong Xiangqiang
Published: April 2024

Introduction

Drip irrigation under mulch film promotes a non-uniform salinity distribution in salt fields. The effect of different N application methods on the growth and yield of cotton under drip irrigation under mulch film conditions in eastern coastal saline-alkaline soils in China remain remained unclear.

Methods

A randomized complete block design was used in the experiment. Three N application methods were assigned: N applied under mulch film (low-salinity area; UM), N applied between mulch films (high-salinity area; BM), and half N applied under mulch film and half between mulch films (HUHB).

Results

Plant height, photosynthesis, Chl content, boll load, biomass, boll weight and boll density under UM were all significantly higher than those under the other two treatments. The N absorption of UM was higher than in the other two treatments, which might be attributed to the expression of GHNRT1.5 and GHNRT2.1. The net NO3- influx in the roots in UM increased significantly compared with that in BM. The yield and FNRE of UM were 3.9% and 9.1%, respectively, and were 26.52% and 90.36% higher than under HUHB and BM treatments.

Discussion

UM not only improved cotton yield but also alleviated the pollution of N residue on drip irrigation under mulch film conditions in salt areas.
Development and validation of Adaptability to Return-to-Work Scale (ARTWS) for cancer patients
Authors: Guo Yu-Jie , Xue Ping , Gu Wen-wen , Su Xiao-qin , Li Jia-mei , Kuai Ben-xin , Xu Jia-shuo , Xie Hui-wen , Han Ping-ping
Published: April 2024

Introduction

The research on cancer patients returning to work in China is still in its infancy, and there is no research and discussion on the adaptability to return-to-work for cancer patients. It is critical to develop the Adaptability to Return-to-Work Scale (ARTWS) for cancer patients and evaluate its psychometric properties.

Methods

The items of the initial scale were compiled based on the theoretical model and literature review results. Through two rounds of Delphi expert consultation (N = 15) and a pilot survey (N = 40), the initial scale was further checked and revised. Conduct a large sample survey (N = 376) and the construct validity and reliability of the ARTWS were assessed by confirmatory factor analysis (CFA) and exploratory factor analysis (EFA).

Results

The final ARTWS consisted of 24 items. “Focusing on rehabilitation,” “Rebuilding Self-efficiency,” and “Adjusting plans” as common factors in determining adaptability to return to work for cancer patients, and the cumulative variance contribution rate for these three factors was 66.6%. The S-CVI of the total scale was 0.979. The Cronbach’s α coefficient was 0.937 and the 2-week test–retest reliability was 0.814.

Discussion

ARTWS has good correlation validity and can be used as a tool to measure the adaptability of cancer patients’ return to work. The presentation of the manuscript in Research Square (https://doi.org/10.21203/rs.3.rs-2323264/v1).
Emophilia: psychometric properties of the emotional promiscuity scale and its association with personality traits, unfaithfulness, and romantic relationships in a Scandinavian sample
Authors: Røed Sol E. , Nærland Randi K. , Strat Marie , Pallesen Ståle , Erevik Eilin K.
Published: April 2024

Emophilia is a suggested stable phenomenon referring to how often and easily an individual falls in love (Jones, 2011). The current study investigated the psychometric properties of the Emotional Promiscuity Scale (EPS, i.e., a measure of emophilia) and its association with personality traits, romantic relationships, and unfaithfulness in a Scandinavian sample. The sample consisted of 2,607 participants, who were recruited through Norwegian and Swedish newspapers. Descriptive analyses of the EPS and a confirmatory factor analysis (CFA) to verify the previously obtained two-factor structure were conducted. Correlations between emophilia and the Big Five and Dark Triad traits were calculated to investigate the discriminative validity of the EPS. Lastly, negative binomial regression analyses were run in which emophilia comprised the independent variable and the number of romantic relationships and number of times being unfaithful constituted the dependent variables. The EPS had satisfactory internal reliability and the responses to the items were normally distributed. The CFA indicated a two-factor structure, although the two factors correlated highly, justifying collapsing them into one dimension. Emophilia showed satisfactory discriminant validity (r < 00.40) against the personality traits included. Lastly, emophilia was positively associated with the number of romantic relationships and times being unfaithful. Future research should aim to improve our understanding of the psychological and behavioral aspects of emophilia.
Physical activity and school adaptation among Chinese junior high school students: chain mediation of resilience and coping styles
Authors: Wu Xinbo , Liang Junwen , Chen Jiaxi , Dong Weixin , Lu Chunxia
Published: April 2024

Background

As a crucial juncture in students’ educational journey, junior high school presents challenges that profoundly influence well-being and academic performance. Physical activity emerges as a pivotal factor shaping the holistic development of junior high school students. Beyond its recognized impact on physical and mental health, engaging in regular physical activity proves effective in augmenting students’ adaptability to school life. Despite its importance, the mechanisms through which physical activity influences school adaptation in junior high school students remain understudied in academic research.

Objective

In exploring the potential mechanisms, this study aims to validate the mediating roles of resilience and coping styles by examining the association between physical activity and school adaptation among junior high school students.

Methods

This study employed cross-sectional survey approach among junior high school students in China. Through the convenience sampling, 1,488 participants aged from 12 to 16 years old (Average age = 13.59, SD = 1.017) from two Junior high schools in Changsha City, Hunan Province were recruited to complete the Physical Activity Scale, School Adaptation Questionnaire for Junior High School Students, Resilience Scale for Adolescents, and Simple Coping Styles Questionnaire. For data analysis, the SPSS 26.0 and Amos 26.0 were used for statistical processing.

Results

The results showed that physical activity exhibited a significant correlation with school adaptation (r = 0.656, p < 0.001). Resilience, positive coping style and negative coping style played partial mediating roles between physical activity and school adaptation, with the effect size were 0.229, 0.170, 0.171. The chain mediation effect size of resilience and positive coping style was 0.042, while the chain mediation effect size of resilience and negative coping style was 0.050.

Conclusion

Physical activity positively predicts Chinese junior high school students’ school adaptation through resilience and coping styles, suggesting that junior high school students should engage in regular physical activity, so as to improve their resilience and positive coping styles, mitigating negative coping styles, thus promoting their school adaptation.
How did you perform? Investigating football players’ perception of self-regulated passing performances under auditory noise environments
Authors: Klatt Stefanie , Otte Fabian Werner , Beavan Adam , Schumacher Tom , Millar Sarah Kate
Published: April 2024

Introduction

This paper deals with the question on how sport performances may be influenced by internal, emotional processes, which stem from outside feedback.

Methods

In terms of methods, players’ subjective performance ratings for four experimental auditory cue conditions were examined; these included both ‘positive’ and ‘negative’ stadium noise, ‘no (auditory) conditions,’ and a control/‘baseline’ condition. This resulted in a qualitative-analytic data set that was obtained succeeding each auditory cue condition using a unique football training machine (i.e., known as ‘Footbonaut’). Without having received any coaching/performance feedback, players were asked to rate and individually comment on their perceived performance ratings for each experimental auditory condition.

Results

Findings indicate stronger and more significant correlations between auditory conditions and subjective ratings compared to the non-auditory condition and its subjective rating. Furthermore, data provides initial insight into players’ emotional experiences during each of the practice conditions.

Discussion

These noteworthy findings on players’ abilities to accurately judge their performances based on selfmonitoring and intrinsic feedback are discussed from an Ecological Dynamics perspective, linked to a Nonlinear Pedagogy for coaching. Here, representative and affective learning designs for skill learning and performance preparation are presented. Finally, a hypothetical catalyst effect of auditory stadium noise on subjective performance rating is proposed.
Recurrent high creatine kinase levels under clozapine treatment - a case report assessing a suspected adverse drug reaction
Authors: Wiss Florine M. , Allemann Samuel S. , Meyer zu Schwabedissen Henriette E. , Stäuble Céline K. , Mikoteit Thorsten , Lampert Markus L.
Published: April 2024

Suspected adverse drug reactions (ADRs) during treatment with clozapine often prompt therapeutic drug monitoring (TDM) in clinical practice. Currently, there is no official recommendation for pharmacogenetic (PGx) testing in the context of clozapine therapy. In this case report, we demonstrate and discuss the challenges of interpreting PGx and TDM results highlighting the possibilities and limitations of both analytical methods. A 36-year-old male patient with catatonic schizophrenia was treated with clozapine. He experienced multiple hospitalizations due to elevated creatine kinase (CK) levels (up to 9000 U/L, reference range: 30-200 U/L). With no other medical explanation found, physicians suspected clozapine-induced ADRs. However, plasma levels of clozapine were consistently low or subtherapeutic upon admission, prompting us to conduct a PGx analysis and retrospectively review the patient’s TDM data, progress notes, and discharge reports. We investigated two possible hypotheses to explain the symptoms despite low clozapine plasma levels: Hypothesis i. suggested the formation and accumulation of a reactive intermediate metabolite due to increased activity in cytochrome P450 3A5 and reduced activity in glutathione S-transferases 1, leading to myotoxicity. Hypothesis ii. proposed under-treatment with clozapine, resulting in ineffective clozapine levels, leading to a rebound effect with increased catatonic symptoms and CK levels. After considering both data sources (PGx and TDM), hypothesis ii. appeared more plausible. By comprehensively assessing all available TDM measurements and examining them in temporal correlation with the drug dose and clinical symptoms, we observed that CK levels normalized when clozapine plasma levels were raised to the therapeutic range. This was achieved through hospitalization and closely monitored clozapine intake. Therefore, we concluded that the symptoms were not an ADR due to altered clozapine metabolism but rather the result of under-treatment. Interpreting TDM and PGx results requires caution. Relying solely on isolated PGx or single TDM values can result in misinterpretation of drug reactions. We recommend considering the comprehensive patient history, including treatment, dosages, laboratory values, clinic visits, and medication adherence.
K-Track-Covid: interactive web-based dashboard for analyzing geographical and temporal spread of COVID-19 in South Korea
Authors: Song Hanbyul , Han Kyulhee , Park Jiwon , Liu Zhe , Goo Taewan , Krishnamurthy Ashok , Park Taesung
Published: April 2024

The COVID-19 pandemic has necessitated the development of robust tools for tracking and modeling the spread of the virus. We present ‘K-Track-Covid,’ an interactive web-based dashboard developed using the R Shiny framework, to offer users an intuitive dashboard for analyzing the geographical and temporal spread of COVID-19 in South Korea. Our dashboard employs dynamic user interface elements, employs validated epidemiological models, and integrates regional data to offer tailored visual displays. The dashboard allows users to customize their data views by selecting specific time frames, geographic regions, and demographic groups. This customization enables the generation of charts and statistical summaries pertinent to both daily fluctuations and cumulative counts of COVID-19 cases, as well as mortality statistics. Additionally, the dashboard offers a simulation model based on mathematical models, enabling users to make predictions under various parameter settings. The dashboard is designed to assist researchers, policymakers, and the public in understanding the spread and impact of COVID-19, thereby facilitating informed decision-making. All data and resources related to this study are publicly available to ensure transparency and facilitate further research.
Time trends in surgical provision and cancer-specific outcomes in patients with stage T2-3 kidney cancer: a SEER-based study
Authors: Song Zhuo , Xing Jizhang , Sun Zhijia , Kang Xiaoli , Li Hongzhao , Ren Gang , Wang Yingjie
Published: April 2024

Background and objective

Surgery is the primary therapy that crucially affects the survival of patients with kidney cancer (KC). However, pertinent surgical decision criteria for individuals with stage T2-3 KC are lacking. This study aimed to display the practical choices and evolving trends of surgical procedures and elucidate their implied value.

Methods

Through the Surveillance, Epidemiology, and End Results (SEER) dataset, the levels and evolving trends of different surgical methods were examined to determine cancer-specific risk of death (CSRD). Additionally, stratification analysis and survival rate analysis were performed to explore the effectiveness of partial nephrectomy (PN).

Results

In this study, 9.27% of patients opted for PN. Interestingly, an upward trend was observed in its decision, with an average annual percentage change (AAPC) of 7.0 (95% CI: 4.8–9.3, P < 0.05). Patients who underwent PN and were in a relatively less severe condition exhibited more favorable CSRD levels (0.17–0.36 vs. 0.50–0.67) and an improvement trend compared with those who underwent radical nephrectomy (RN) (AAPC: −1.9 vs. −0.8). Further analysis showed that the levels of CSRD and survival rates for patients opting for different surgical methods followed a similar pattern.

Conclusions

This study showed that RN was still the most common surgical method. Patients with stage T2-3 KC had an increasing preference for PN and exhibited more favorable cancer-related survival outcomes, which underscores the need for further investigation and validation.
Navigating HIV-Related Stigma in Switzerland: A Qualitative Study
Authors: Gilles Ingrid , Jackson-Perry David , Le Saux Clara , Storari Chiara , Cart-Richter Ellen , Keserue Pittet Oriana , Darling Katharine E. A.
Published: April 2024

Objectives: This study sought to understand how people living with HIV experience, perceive, and navigate stigma in their everyday life and in care settings in an urban French-speaking area in Switzerland.

Methods: Semi-structured interviews were carried out with 19 people living with HIV in Lausanne concerning their experience of HIV-related stigma in both everyday life and in healthcare settings. Content analysis was performed to identify main and sub-themes.

Results: “Living with HIV” posed little or no difficulty for participants. However, the burden of anticipated and internalized HIV-related stigma played a disproportionately large role in their lives. Participants considered the general population’s low level of knowledge about HIV as problematic in this regard. While participants reported few examples of enacted stigma generally, healthcare environments were sometimes experienced as sites of prejudice and discrimination. However, some healthcare professionals were also sources of information and knowledge, contributing to participants’ “journeys of self-acceptance.”

Conclusion: Even in an urban environment in a country with ready access to healthcare and education, HIV-related stigma remains a concern for people living with HIV.
The Pre-Exposure Prophylaxis Stigma Scale: Measurement Properties of an Adaptation in German and French
Authors: Ort Alexander , Bardy Tess
Published: April 2024

Objectives:

This study aimed to adapt and validate the HIV PrEP Stigma Scale (HPSS) in French and German languages (HPSS-FR/DE) and assess its applicability across diverse linguistic and cultural contexts.

Methods:

The original scale was adapted to French and German and administered through an online survey in multiple European nations. A four-factor structure was extracted from the data, including negative social consequences, social pressure, self-support, and external support. The scale’s construct validity, reliability, and cross-linguistic consistency were evaluated.

Results:

The adapted HPSS-FR/DE demonstrated robust psychometric properties, good construct validity, acceptable reliability, and consistent measurement across different languages. This adaptation enhances its utility in multicultural settings, offering a comprehensive tool to assess PrEP-related stigma.

Conclusion:

This study provides a suitable tool to address PrEP stigma in multicultural environments to enhance PrEP uptake and adherence among men who have sex with men. Moreover, it lays the groundwork for further investigations into PrEP stigma across diverse populations and cultural settings, enabling the development of targeted public health interventions and policies to combat this issue effectively.
Empirical Modeling of Subcritical Hopf Bifurcation of Thermoacoustic Stirling Engine
Authors: Lai Chuan-Heng , Hsu Shu-Han
Published: April 2024

This study models the subcritical Hopf bifurcation in thermoacoustic Stirling engines using the Stuart–Landau model, highlighting the role of nonlinear dynamics. By inducing self-sustained oscillations and measuring pressure fluctuations across different temperature gradients imposed on the regenerator, we reveal the engine’s transition to a nonlinear domain, characterized by heightened oscillation amplitudes and unique periodic patterns. Interpreted Landau constants and growth rates illuminate the stabilizing effects of nonlinear dynamics, demonstrating the Stuart–Landau model’s applicability in thermoacoustic engine analysis. Our research confirms that this empirically refined model reliably describes oscillation amplitudes and transient phenomena, contributing valuable perspectives for advancing thermoacoustic engine design and operational understanding.
Thermal Image and Inverter Data Analysis for Fault Detection and Diagnosis of PV Systems
Authors: Baltacı Özge , Kıral Zeki , Dalkılınç Konuralp , Karaman Oğulcan
Published: April 2024

The world’s energy demand is on the rise, leading to an increased focus on renewable energy options due to global warming and rising emissions from fossil fuels. To effectively monitor and maintain these renewable energy systems connected to electrical grids, efficient methods are needed. Early detection of PV faults is vital for enhancing the efficiency, reliability, and safety of PV systems. Thermal imaging emerges as an efficient and effective technique for inspection. On the other hand, evidence indicates that monitoring inverters within a solar energy farm reduces maintenance expenses and boosts production. Optimizing the efficiency of solar energy farms necessitates comprehensive analytics and data on every inverter, encompassing voltage, current, temperature, and power. In this study, our objective was to perform two distinct fault analyses utilizing image processing techniques with thermal images and machine learning techniques using inverter and other physical data. The results show that hotspot and bypass failures on the panels can be detected successfully using these methods.
Automatic Estimation of the Interference Subspace Dimension Threshold in the Subspace Projection Algorithms of Magnetoencephalography Based on Evoked State Data
Authors: Zhao Ruochen , Wang Ruonan , Gao Yang , Ning Xiaolin
Published: April 2024

A class of algorithms based on subspace projection is widely used in the denoising of magnetoencephalography (MEG) signals. Setting the dimension of the interference (external) subspace matrix of these algorithms is the key to balancing the denoising effect and the degree of signal distortion. However, most current methods for estimating the dimension threshold rely on experience, such as observing the signal waveforms and spectrum, which may render the results too subjective and lacking in quantitative accuracy. Therefore, this study proposes a method to automatically estimate a suitable threshold. Time–frequency transformations are performed on the evoked state data to obtain the neural signal of interest and the noise signal in a specific time–frequency band, which are then used to construct the objective function describing the degree of noise suppression and signal distortion. The optimal value of the threshold in the selected range is obtained using the weighted-sum method. Our method was tested on two classical subspace projection algorithms using simulation and two sensory stimulation experiments. The thresholds estimated by the proposed method enabled the algorithms to achieve the best waveform recovery and source location error. Therefore, the threshold selected in this method enables subspace projection algorithms to achieve the best balance between noise removal and neural signal preservation in subsequent MEG analyses.