bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical Investigations on the Influencing Factors of Rapid Fire Spread of Flammable Cladding in a High-Rise Building
Authors: Hassan Md Kamrul , Hossain Md Delwar , Gilvonio Michael , Rahnamayiezekavat Payam , Douglas Grahame , Pathirana Sameera , Saha Swapan
Published: September 2022

This paper investigates aluminium composite panels (ACPs) to understand the fire behaviour of combustible cladding systems under different fire scenarios. A fire dynamics simulator (FDS) is used to develop the numerical model of full-scale fire tests of combustible cladding systems using the procedures of the British BS 8414.1 standards. The results obtained from the FDS models are verified with test data. Seven test scenarios are investigated with four distinct parameters, i.e., cavity barrier, air-cavity gap, panel mounting (with and without joining gaps between the panels), and material combustibility qualities. A critical air-cavity gap (50–100 mm) is established at which maximum fire spread is noticed. Furthermore, variations in the cavity barrier, panel mounting, and material combustibility significantly impact the rapid fire spread of ACP cladding systems and the internal failure criterion. The results from the present study can serve as a basis for future research on the full-scale fire-test development of combustible ACPs.
Targeted Anti-Mitochondrial Therapy: The Future of Oncology
Authors: Taghizadeh-Hesary Farzad , Akbari Hassan , Bahadori Moslem , Behnam Babak
Published: September 2022

Like living organisms, cancer cells require energy to survive and interact with their environment. Mitochondria are the main organelles for energy production and cellular metabolism. Recently, investigators demonstrated that cancer cells can hijack mitochondria from immune cells. This behavior sheds light on a pivotal piece in the cancer puzzle, the dependence on the normal cells. This article illustrates the benefits of new functional mitochondria for cancer cells that urge them to hijack mitochondria. It describes how functional mitochondria help cancer cells’ survival in the harsh tumor microenvironment, immune evasion, progression, and treatment resistance. Recent evidence has put forward the pivotal role of mitochondria in the metabolism of cancer stem cells (CSCs), the tumor components responsible for cancer recurrence and metastasis. This theory highlights the mitochondria in cancer biology and explains how targeting mitochondria may improve oncological outcomes.
Mycobacterium tuberculosis Genotypes and Drug Susceptibility Test Results from Timor-Leste: A Pilot Study
Authors: Sarmento Nevio , Meumann Ella M. , Pereira Helder M. , Lopes Constantino , Globan Maria , Hall Charlotte , Di Palma Matthew , Hersch Nicole , Horan Kristy , Ralph Anna P. , Francis Joshua R.
Published: September 2022

Tuberculosis (TB) is prevalent and a major public health problem in Timor-Leste. The government of Timor-Leste is prioritising the surveillance of TB and drug-susceptibility testing (DST) to understand the burden of TB and TB drug resistance in the country. Moreover, little is known about the origin of Mycobacterium tuberculosis (MTB) in Timor-Leste. This study reports MTB DST and sequencing for Timor-Leste. A pilot study was carried out in which a convenience sample of TB isolates from mucopurulent sputum collected from presumptive TB patients in the capital Dili between July and December 2016 was tested for phenotypic and genotypic evidence of drug resistance. Standard MTB culture was performed at the Timor-Leste National Health Laboratory (NHL). The MTB isolates were sent to the Victorian Infectious Diseases Reference Laboratory (VIDRL) in Australia for DST and sequencing. Overall, 36 MTB isolates were detected at the NHL; 20 isolates were recovered during sub-culturing at VIDRL. All 20 isolates were susceptible to rifampicin, isoniazid, pyrazinamide, and ethambutol, with no genotypic markers of resistance identified. On sequencing, lineage 4 was the most common. The results of this study provide a small snapshot of MTB diversity and resistance in an under-sampled region with very high TB incidence. Future investment in whole-genome sequencing capacity in Timor-Leste will make it possible to undertake further, more representative analyses that may be used to evaluate transmission dynamics and epidemiology of genotypic markers of resistance.
IL17F Expression as an Early Sign of Oxidative Stress-Induced Cytotoxicity/Apoptosis
Authors: Bauer Mario , Fink Beate , Anderegg Ulf , Röder Stefan , Zenclussen Ana Claudia
Published: September 2022

Interleukin 17F (IL17F) has been found to be involved in various inflammatory pathologies and has recently become a target for therapeutic purposes. In contrast to IL17F secreted by immune cells, the focus of this study is to describe the triggers of IL17F release in non-immune cells with a particular focus on IL17F-induced fibrosis. IL17F induction was examined in human lung epithelial (BEAS-2B) and myeloid cell lines as well as in peripheral blood mononuclear cells after in vitro exposure to aqueous cigarette smoke extract (CSE), inorganic mercury, cadmium or the apoptosis inducer brefeldin A. Fibrosis was examined in vitro, evaluating the transition of human primary dermal fibroblasts to myofibroblasts. We observed that all stressors were able to induce IL17F gene expression regardless of cell type. Interestingly, its induction was associated with cytotoxic/apoptotic signs. Inhibiting oxidative stress by N-acetylcysteine abrogated CSE-induced cytotoxic and IL17F-inducing effects. The induction of IL17F was accompanied by IL17F protein expression. The transition of fibroblasts into myofibroblasts was not influenced by either recombinant IL17F or supernatants of CSE-exposed BEAS-2B. In addition to IL17F secretion by specialized or activated immune cells, we underscored the cell type-independent induction of IL17F by mechanisms of inhibitable oxidative stress-induced cytotoxicity. However, IL17F was not involved in dermal fibrosis under the conditions used in this study.
RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats
Authors: Bao Terigele , Feng Lan , Cho Sungbo , Yu Hongzhen , Jin Wenjie , Dai Lili , Zhang Junqing , Bai Laxinamujila , Fu Minghai , Chen Yongsheng
Published: September 2022

This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the mechanism behind this protective effect. Rats were pretreated with MD-4 (0.3, 1.5, or 3 g/kg per day) for 21 days before inducing gastric ulcers by oral administration with indomethacin (30 mg/kg). Unulcerated and untreated healthy rats were used as controls. Effects of the treatment were assessed based on the ulcer index, histological and pathological examinations, and indicators of inflammation, which were determined by enzyme-linked immunosorbent assay. Transcriptomic analysis was performed for identifying potential pharmacological mechanisms. Eventually, after identifying potential target genes, the latter were validated by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). After pretreatment with MD-4, gastric ulcers, along with other histopathological features, were reduced. MD-4 significantly (p < 0.05) increased the superoxide dismutase (SOD) levels in ulcers and reduced pepsin, TNF-α, and IL-6 levels. RNA-seq analysis identified a number of target genes on which MD-4 could potentially act. Many of these genes were involved in pathways that were linked to anti-inflammatory and antioxidant responses, and other protective mechanisms for the gastric mucosa. qRT-PCR showed that altered expression of the selected genes, such as Srm, Ryr-1, Eno3, Prkag3, and Eef1a2, was consistent with the transcriptome results. MD-4 exerts protective effects against IND-induced gastric ulcers by reducing inflammatory cytokines and pepsin and increasing the expression of SOD levels. Downregulation of Srm, Ryr-1, Eno3, Prkag3, and Eef1a2 genes involved in regulating arginine and proline metabolism, calcium signaling pathway, HIF-1 signaling pathway, oxytocin signaling pathway, and legionellosis are possibly involved in MD-4-mediated protection against gastric ulcers.
Combining Gene Mutation with Expression of Candidate Genes to Improve Diagnosis of Escobar Syndrome
Authors: Najjar Dorra , Chikhaoui Asma , Zarrouk Sinda , Azouz Saifeddine , Kamoun Wafa , Nassib Nabil , Bouchoucha Sami , Yacoub-Youssef Houda
Published: September 2022

Escobar syndrome is a rare, autosomal recessive disorder that affects the musculoskeletal system and the skin. Mutations in the CHRNG and TPM2 genes are associated with this pathology. In this study, we conducted a clinical and genetic investigation of five patients and also explored via in silico and gene expression analysis their phenotypic variability. In detail, we identified a patient with a novel composite heterozygous variant of the CHRNG gene and two recurrent mutations in both CHRNG and TPM2 in the rest of the patients. As for the clinical particularities, we reported a list of modifier genes in a patient suffering from myopathy. Moreover, we identified decreased expression of IGF-1, which could be related to the short stature of Escobar patients, and increased expression of POLG1 specific to patients with TPM2 mutation. Through this study, we identified the genetic spectrum of Escobar syndrome in the Tunisian population, which will allow setting up genetic counseling and prenatal diagnosis for families at risk. In addition, we highlighted relevant biomarkers that could differentiate between patients with different genetic defects.
Comparative Analysis on the Evolution of Flowering Genes in Sugar Pathway in Brassicaceae
Authors: Zhang Yingjie , Zhu Qianbin , Ai Hao , Feng Tingting , Huang Xianzhong
Published: September 2022

Sugar plays an important role in regulating the flowering of plants. However, studies of genes related to flowering regulation by the sugar pathway of Brassicaceae plants are scarce. In this study, we performed a comprehensive comparative genomics analysis of the flowering genes in the sugar pathway from seven members of the Brassicaceae, including: Arabidopsis thaliana, Arabidopsis lyrata, Astelia pumila, Camelina sativa, Brassica napus, Brassica oleracea, and Brassica rapa. We identified 105 flowering genes in the sugar pathway of these plants, and they were categorized into nine groups. Protein domain analysis demonstrated that the IDD8 showed striking structural variations in different Brassicaceae species. Selection pressure analysis revealed that sugar pathway genes related to flowering were subjected to strong purifying selection. Collinearity analysis showed that the identified flowering genes expanded to varying degrees, but SUS4 was absent from the genomes of Astelia pumila, Camelina sativa, Brassica napus, Brassica oleracea, and Brassica rapa. Tissue-specific expression of ApADG indicated functional differentiation. To sum up, genome-wide identification revealed the expansion, contraction, and diversity of flowering genes in the sugar pathway during Brassicaceae evolution. This study lays a foundation for further study on the evolutionary characteristics and potential biological functions of flowering genes in the sugar pathway of Brassicaceae.
Effect of Prolonged Cold Storage on the Dynamics of the Enzymatic and Non-Enzymatic Antioxidant System in the Mesocarp of Avocado (Persea americana) cv. Hass: Relationship with Oxidative Processes
Authors: Chirinos Rosana , Ramon Karolina , Mendoza Mirtha , Figueroa-Merma Andrés , Pacheco-Ávalos Alejandro , Campos David , Pedreschi Romina
Published: September 2022

This work evaluated the enzymatic and non-enzymatic antioxidant defense systems of avocados cv. Hass stored at 7 ± 0.5 °C for 10, 20, and 30 d, and at the stage of edible ripeness. The enzymatic antioxidant enzyme system included superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), and the non-enzymatic antioxidant system was composed of total phenolic compounds (TPC), total carotenoids (TC), α-, β-, and γ-tocopherols, as well as hydrophilic (H-AOX) and lipophilic (L-AOX) antioxidant activities. In addition, polyphenol oxidase (PPO) and lipoxygenase (LOX) activities, TBARS values and pulp browning area were determined. At edible ripeness, low SOD and POD but higher CAT activities were evidenced in response to their joint participation in the oxidative stress developed. In addition, low content of γ-tocopherol and higher contents of TPC and TC were evidenced and suggest their individual or joint participation in defense against oxidation. The other compounds and activities evaluated tended to remain constant. Oxidative damage was evidenced by the increase in PPO activity and TBARS values, while LOX did not play a significant role. Pulp browning area did not surpass 6% in affected fruit. The results indicate that under these conditions oxidative stress was largely restrained by the endogenous fruit antioxidant defense system.
Late Ripening Apple Production Benefits from High Shading and Water Limitation under Exclusion Netting
Authors: Boini Alexandra , Bortolotti Gianmarco , Perulli Giulio Demetrio , Venturi Melissa , Bonora Alessandro , Manfrini Luigi , Corelli-Grappadelli Luca
Published: September 2022

In highly solar irradiated areas, apple production can face challenges due to high evaporative water demands. Shading can be used to lower irrigation requirements and make apple growing more sustainable. In this trial, a white exclusion net (40% shading) integrated with rain protection was compared with a regular anti-hail black net (20% shading), on Rosy Glow apple. Crop physiology, yield and quality parameters were monitored during two consecutive years, under conditions of full and restricted irrigation. Since Et0 under the two cover systems was different, their respective 100% irrigation replacement was different; both covers also received a restricted irrigation treatment (70% replacement of Et0). Tree physiology (midday stem water potential, leaf gas exchanges, seasonal fruit growth) was not affected, neither by less light nor by less water. Moreover, marketable yield, fruit color and soluble solid content were improved under the more shaded environment, even when the irrigation volume was limited. These results are encouraging, as an overall 50% of water was saved (ca. 190 mm tree−1 per year), compared to the control irrigation treatment, under a classic anti-hail system (ca. 370 mm tree−1 per year).
A Pilot Study on the Concentration, Distribution and Bioaccumulation of Polybrominated Diphenyl Ethers (PBDEs) in Tissues and Organs of Grassland Sheep
Authors: Chen Wenming , Yang Xinrui , Bao Junsong , Lin Ziyi , Li Tianwei , Wang Ying , Zhang Aiqin , Hu Jicheng , Jin Jun
Published: September 2022

Polybrominated diphenyl ether (PBDE) concentrations in various tissues and organs of grassland sheep from Inner Mongolia, China, were determined. The abilities of PBDEs binding to ovine serum albumin (OSA) and Cytochrome P450 enzyme (CYP3A24) were assessed by fluorescence spectroscopy and molecular docking simulations. The PBDE concentrations in the sheep tissue and organ samples were 33.4–167 pg/g dw. The distribution of PBDEs in sheep organs and tissues is affected not only by the function of organs and tissues, but also by the characteristics of PBDEs. Adipose tissue tends to bioaccumulate more-brominated BDEs (BDE-154, -153, and -183), but muscle tissues and visceral organs mainly bioaccumulate less-brominated BDEs. The distribution of PBDEs in visceral organs is mainly affected by the transport of ovine serum albumin (OSA) and the metabolism of CYP3A24 enzyme. The distribution of PBDEs in adipose tissue and brain is mainly affected by their logKOW.
Systematic Review of Multi-Dimensional Vulnerabilities in the Himalayas
Authors: Sultan Hameeda , Zhan Jinyan , Rashid Wajid , Chu Xi , Bohnett Eve
Published: September 2022

The Himalayan region is a fragile high mountain landscape where the population experiences acute vulnerability within a complex coupled human–natural system due to environmental, social, and economic linkages. The lack of significant regional and spatial knowledge of multi-faceted vulnerabilities hinders any potential recommendations to address these vulnerabilities. We systematically reviewed the literature to recommend mitigation interventions based on the region’s socio-economic and ecological vulnerability research to date. We applied the PRISMA (Preferred Reporting of Items for Systematic Review and Meta-Analysis) criteria to search for results from four comprehensive databases. For our assessment, we compiled a final sample (n = 59) of vulnerability research papers to examine the vulnerability types, spatial variation, assessment methodology, and significant drivers of change. Our study represented all Himalayan countries, namely, India, Nepal, Pakistan, China, and Bhutan. More than half of the vulnerability studies were conducted in the central Himalayan region, a quarter in the western Himalayas, and a few in the eastern Himalayas. Our review revealed that the primary drivers of change were climate change, land use/land cover, and glacial lake formation. The vulnerability assessments in the Himalayan region primarily used social science methods as compared to natural science methods. While the vulnerability studies seldom assessed mitigation interventions, our analysis identified fourteen recommendations. The recommended interventions mainly included policy interventions, livelihood improvement, and adaptation measures. This study emphasized that sustainable development requires cross-sectoral interventions to manage existing resources and mitigate the confronting vulnerabilities of the region.
Determinants of Dietary Vitamin D Intake in Population-Based Cohort Sample of Polish Female Adolescents
Authors: Lachowicz Katarzyna , Stachoń Małgorzata
Published: September 2022

Vitamin D has a pleiotropic effect and its deficiency is a risk factor for many diseases. The purpose of this study was to analyze the dietary intake of vitamin D and the factors determining this intake by female post-primary school students in Poland. The study was conducted on a nationwide sample of 4469 female Polish adolescents (aged 14–20) recruited from all regions across Poland. The vitamin D intake was assessed using VIDEO-FFQ (Vitamin D Estimation Only—Food Frequency Questionnaire). The median dietary vitamin D intake was 2.33 μg per day and it was lower than the 15 μg recommended in Poland for more than 98% of the group. The highest vitamin D intake per day was noted for fish (0.52 μg), whereas the lowest was noted for fats (0.04 μg). Factors that influenced the dietary vitamin D intake were the amount and species of fish consumed, region of residence, use of vitamin D supplements, and vegetarian or vegan diets. In contrast, vitamin D intake did not depend on body mass index and age. Based on the results of the survey, it can be concluded that the alarmingly low intake of vitamin D by Polish female adolescents is a result of the limited supply of vitamin D primarily from fish and fish products. This may be due to insufficient nutritional knowledge, indicating an urgent need to educate the surveyed population in this area.
Kinematic Analysis of the Underwater Undulatory Swimming Cycle: A Systematic and Synthetic Review
Authors: Veiga Santiago , Lorenzo Jorge , Trinidad Alfonso , Pla Robin , Fallas-Campos Andrea , de la Rubia Alfonso
Published: September 2022

The increase of low-cost technology for underwater filming has made quantitative analysis an affordable resource for swimming coaches on a frequent basis. In this context, a synthesis of the kinematic determinants of underwater undulatory swimming (UUS) seems to be lacking. The aim of the present study was to synthesise the scientific evidence on the kinematic characteristics of competitive swimmers during UUS and the main kinematic determinants of UUS performance, as well as to summarise the main methodological considerations for UUS kinematic analysis. A systematic literature search was performed through four electronic databases following the PRISMA guidelines and STROBE for evaluating the quality of the included studies. Twenty-three research studies from the first search and two from the second search were finally considered. In total, 412 competitive swimmers (321 males and 91 females) with a performance standard of international B (11%), national (51%), or regional (35%) level were analysed. Most studies focused on a two-dimensional analysis of the ventral UUS performed from a push start and filmed 6–12 m from the starting wall. Kinematic analysis of UUS included kicking parameters (kicking length, frequency, and amplitude) as well as selected segmental kinematics in 76% of studies and the analysis of UUS performance determinants in 36%. Information about the determinants of UUS performance was inconsistent due in part to inconsistencies in the definition of kinematic parameters. Further research studies where automatic motion capture systems are applied to the analysis of UUS on the aforementioned conditions should be conducted.
A New Approach to Monitoring Urban Built-Up Areas in Kunming and Yuxi from 2012 to 2021: Promoting Healthy Urban Development and Efficient Governance
Authors: Zhang Jun , Zhang Xue , Tan Xueping , Yuan Xiaodie
Published: September 2022

With the rapid expansion of urban built-up areas in recent years, accurate and long time series monitoring of urban built-up areas is of great significance for healthy urban development and efficient governance. As the basic carrier of urban activities, the accurate monitoring of urban built-up areas can also assist in the formulation of urban planning. Previous studies on urban built-up areas mainly focus on the analysis of a single time section, which makes the extraction results exist with a certain degree of contingency. In this study, a U-net is used to extract and monitor urban built-up areas in the Kunming and Yuxi area from 2012 to 2021 based on nighttime light data and POI_NTL (Point of Interest_Nighttime light) data. The results show that the highest accuracy of single nighttime light (NTL) data extraction was 89.31%, and that of POI_NTL data extraction was 95.31%, which indicates that data fusion effectively improves the accuracy of built-up area extraction. Additionally, the comparative analysis of the results of built-up areas and the actual development of the city shows that NTL data is more susceptible to urban emergencies in the extraction of urban built-up areas, and POI (Point of interest) data is subject to the level of technology and service available in the region, while the combination of the two can avoid the occasional impact of single data as much as possible. This study deeply analyzes the results of extracting urban built-up areas from different data in different periods and obtains the feasible method for the long time sequence monitoring of urban built-up areas, which has important theoretical and practical significance for the formulation of long-term urban planning and the current high-quality urban development.
Monitoring of Thermal Comfort and Air Quality for Sustainable Energy Management inside Hospitals Based on Online Analytical Processing and the Internet of Things
Authors: Garcés Hugo O. , Durán Claudia , Espinosa Eduardo , Jerez Alejandro , Palominos Fredi , Hinojosa Marcela , Carrasco Raúl
Published: September 2022

There is a need to ensure comfortable conditions for hospital staff and patients from the point of view of thermal comfort and air quality so that they do not affect their performance. We consider the need for hospital employees and patients to enjoy conditions of greater well-being during their stay. This is understood as a comfortable thermal sensation and adequate air quality, depending on the task they are performing. The contribution of this article is the formulation of the fundamentals of a system and platform for monitoring thermal comfort and Indoor Air Quality (IAQ) in hospitals, based on an Internet of Things platform composed of a low-cost sensor node network that is capable of measuring critical variables such as humidity, temperature, and Carbon Dioxide (CO2). As part of the platform, a multidimensional data model with an On-Line Analytical Processing (OLAP) approach is presented that offers query flexibility, data volume reduction, as well as a significant reduction in query response times. The experimental results confirm the suitability of the platform’s data model, which facilitates operational and strategic decision making in complex hospitals.
The Leading Factors of Obesity and Severe Obesity in Korean Adults during the COVID-19 Pandemic
Authors: Lee Myung-Nam , Choi Young-Soon , Kim Sang-Dol
Published: September 2022

(1) Background: During the coronavirus disease 2019 (COVID-19) pandemic, the prevalence of obesity or severe obesity has increased worldwide to the point that it has even been referred to as a new disease. However, the impacts of the pandemic on obesity or severe obesity remain unclear, thus requiring a thorough examination of the leading factors of obesity and severe obesity during this time. (2) Methods: The required dataset for this study was extracted from the eighth (2019–2020) Korea National Health and Nutrition Examination Survey (KNHNES). The survey’s data for 2019 and 2020 were analyzed to confirm the leading factors of obesity and severe obesity before and after the outbreak of COVID-19. The samples were weighted, and the data were analyzed using multiple logistic regression. (3) Results: In 2020, the prevalence of obesity and severe obesity in the Korean adult population aged 19 and over, compared with the normal weight group, showed significant increases of 2.5% and 1.4%, respectively, compared with those rates in 2019 (p < 0.05). The main variables affecting the obesity prevalence in Korean adults aged 19 and over in 2020 were gender, age, sitting time per day, and walking time per day, and the factors affecting severe obesity were gender and age. Meanwhile, the daily energy intake variable had no impact on the prevalence of obesity and severe obesity. (4) Conclusions: These findings will serve as a basis to help the present management directions and treatment approaches for individuals with obesity or severe obesity in the post-COVID-19 era.
Soil Heavy Metal Content and Enzyme Activity in Uncaria rhynchophylla-Producing Areas under Different Land Use Patterns
Authors: Yang Xiuyuan , Zhang Zhenming , Sun Chao , Zeng Xianping
Published: September 2022

In this study, we investigated the content of soil heavy metals, the level of heavy metal pollution and the characteristics of soil enzyme activity under three different land use patterns of Uncaria rhynchophylla base, forestland and wasteland in Jianhe County, Qiandongnan Prefecture, Guizhou Province, revealing the intrinsic correlation between heavy metal content and soil enzyme activity to reveal the relationship between soil enzyme activity and heavy metal content under different land use patterns in the Uncaria rhynchophylla production area. The results showed that soil Cd and Hg contents in Uncaria rhynchophylla base both exceeded the national soil background value. The single pollution index indicated that Cd had the greatest contribution to Pn, and the comprehensive pollution index (Pn) demonstrated no heavy metal pollution in the soil of Uncaria rhynchophylla-producing areas. Under different land use patterns, the enzyme activity was forestland > wasteland > Uncaria rhynchophylla base, and catalase and acid phosphatase activities presented significant spatial differences (p < 0.05). The correlation between soil enzyme activity and heavy metal content was uncertain due to the changes in land use patterns and heavy metal species. The proportions of positive correlation and negative correlation between soil enzyme activity and heavy metals in Uncaria rhynchophylla base were 50%, respectively. In the forestland, soil enzyme activity was positively correlated with heavy metals, while in the wasteland, soil enzyme activity was negatively correlated with heavy metals. This study revealed that the changes in heavy metal content should be focused on for the soil quality in Uncaria rhynchophylla-producing areas under different land use patterns. The results of the study provide some basic theoretical references for the improvement of soil quality in the production area of Uncaria rhynchophylla under different land use practices.
Cardiac Arrest after Small Doses Ropivacaine: Local Anesthetic Systemic Toxicity in the Course of Continuous Femoral Nerve Blockade
Authors: Gola Wojciech , Bialka Szymon , Zajac Marek , Misiolek Hanna
Published: September 2022

Background: The paper presents a case report of an episode of local anesthetic systemic toxicity (LAST) with cardiac arrest after continuous femoral nerve blockade. Case report: A 74-year-old patient burdened with hypertension and osteoarthritis underwent elective total knee replacement surgery. After surgery, a continuous femoral nerve blockade was performed and an infusion of a local anesthetic (LA) was started using an elastomeric pump. Five hours after surgery, the patient had an episode of generalized seizures followed by cardiac arrest. After resuscitation, spontaneous circulation was restored. In the treatment, 20% lipid emulsion was used. On day two of the ICU stay, the patient was fully cardiovascularly and respiratorily stable without neurological deficits and was discharged to the orthopedic department to continue treatment. Conclusion: Systemic toxicity of LA is a serious and potentially fatal complication of the use of LA in clinical practice. It should be noted that in nearly 40% of patients, LAST deviates from the classic and typical course and may have an atypical manifestation, and the first symptoms may appear with a long delay, especially when continuous blockades are used. Therefore, the proper supervision of the patient and the developed procedure in the event of LAST is undoubtedly important here.
How Did Zero-Markup Medicines Policy Change Prescriptions in the Eyes of Patients?—A Retrospective Quasi-Experimental Analysis
Authors: Cheng Hanchao , Zhang Yuou , Sun Jing , Liu Yuanli
Published: September 2022

Background: China implemented the zero-markup medicines policy to reverse the overuse of medicine in public health institutions, by changing the distorted financing mechanism, which heavily relies on revenue generated from medicines. The zero-markup medicines policy was progressively implemented in city public hospitals from 2015 to 2017. Objective: This study is expected to generate convincing evidence with subjective measurements and contribute to a more comprehensive evaluation of the policy from both objective and subjective perspectives. Methods: This study was based on a large patient-level dataset with a quasi-experimental design. We employed the difference-in-difference (DID) method, combined with propensity score matching methods, to estimate the causal effect of the policy in reducing overprescriptions from the patient perspective. Results: The study estimated a statistically significant increased probability that the responded outpatients denied overprescription in their visiting hospitals. The mean interacted policy effect, in percentage points, of all observations were positive (logit DID model: 0.15, z = 10.27, SE = 0.01; PSM logit DID model: 0.15, z = 10.26, SE = 0.01; PSM logit DID hospital fixed-effect model: 0.12, z = 3.00, SE = 0.04). Discussion: The policy might reduce overprescription in public hospitals from the patient’s perspective. The patient’s attitude is one aspect of a comprehensive policy evaluation. The final concrete conclusion of the policy evaluation can only be made through a systematic review of the studies with rigorous design and with both objective and subjective measurements.
Unraveling the Protective Effects of Cognitive Reserve on Cognition and Brain: A Cross-Sectional Study
Authors: Szcześniak Dorota , Lenart-Bugla Marta , Misiak Błażej , Zimny Anna , Sąsiadek Marek , Połtyn-Zaradna Katarzyna , Zatońska Katarzyna , Zatoński Tomasz , Szuba Andrzej , Smith Eric E. , Yusuf Salim , Rymaszewska Joanna
Published: September 2022

This study aimed to investigate the hypothesis that brain maintenance expressed in white matter hyperintensities and brain reserves, defined as gray and white matter volumes, mediate the association between cognitive reserve (CR) and cognitive performance. A cross-sectional population-based observational study was conducted, and the final study sample consisted of 763 participants (282 men and 481 women) with a mean age of 61.11 years (±9.0). Data from different categories were collected from study participants, such as demographic, lifestyle, medical, and psycho-social characteristics. All participants underwent a detailed psychometric evaluation (MoCA and DSST) followed by a brain MRI. Volumetric measurements of the total gray matter (GMvol), total white matter (WMvol), and white matter hyperintensities (WMHvol) were performed using the Computational Anatomy Toolbox 12 (CAT12) and Statistical Parametric Maps 12 (SPM12) based on 3D T1-weighted sequence. Significant direct and indirect effects of cognitive reserve on cognitive functioning were measured with both scales—the MoCA and DSST. In each mediation model, the volumes of WMH and GM were significant mediators for the association between cognitive reserve and cognitive performance. This study confirms the importance of strengthening the cognitive reserve in the course of life through potentially modifiable effects on both cognition and the brain.
Managing the Wellbeing of Elite Rugby Union Players from an Occupational Safety and Health Perspective
Authors: Chen Yanbing , Buggy Conor , Kelly Seamus
Published: September 2022

The intense, physical contact nature of rugby union often encourages the normalization of risk-taking behaviour resulting in a relatively high acceptance of risk. This study aims to explore safety culture in rugby union from an OSH perspective, with the purpose of assisting coaches and management in their decision-making processes to improve players’ health, welfare, and long-term well-being. In terms of data collection, this study involved semi-structured interviews with senior support staff (n = 15) in elite rugby union. Interview transcripts underwent inductive analysis prior to an abductive analysis that was guided by an established occupational-safety-and-health (OSH) framework. Rugby union players’ safety can be considered from two dimensions: management’s commitment to safety (i.e., safety prioritization, safety empowerment, and safety justice), players’ involvement in safety (i.e., safety prioritization, and trust in other players’ safety competence, and players’ safety concern for the opposition players). Within the themes identified, players’ attitude towards their opponents’ safety which has been rarely considered as a factor for injury prevention is also discussed in this study. If sport support staff (i.e., managers/coaches/medical) can become more involved in players’ performance-orientated training using OSH management processes to aid in their decision-making, their exists the capacity to benefit players’ safe return to play after injury rehabilitation. Meanwhile, directing the development of appropriate behavioural educational interventions to raise safety-awareness amongst players can improve their long-term health and well-being and provide them with the necessary safety and health information to support their own decision-making processes. As a multidisciplinary design, this study contributes new multidisciplinary insights that have the potential to advance managerial practices utilizing an OSH perspective, including decision-making supporting risk alleviation for safety and long-term health and wellbeing initiatives in competitive team sports.
Indigeneity and Likelihood of Discharge to Psychiatric Hospital in an Australian Deliberate Self-Poisoning Hospital-Treated Cohort
Authors: McGill Katie , Salem Amir , Hanstock Tanya L. , Heard Todd R. , Garvey Leonie , Leckning Bernard , Whyte Ian , Page Andrew , Carter Greg
Published: September 2022

Hospital-treated self-harm rates for Aboriginal and Torres Strait Islander (Indigenous) people are at least double those for other Australians. Despite this, limited research has explored the relationship between Indigeneity and the clinical management of hospital-treated deliberate self-harm. A retrospective clinical cohort study (2003–2012) at a regional referral centre (NSW) for deliberate self-poisoning was used to explore the magnitude and direction of the relationship between Indigeneity and discharge destination (psychiatric hospital vs. other) using a series of logistic regressions. There were 149 (4%) Indigenous and 3697 (96%) non-Indigenous deliberate self-poisoning admissions during the study period. One-third (31%) were referred to the psychiatric hospital at discharge; Indigenous 21% (n = 32) vs. non-Indigenous 32% (n = 1175). Those who identified as Indigenous were less likely to be discharged to the psychiatric hospital, OR 0.59 (0.40–0.87) at the univariate level, with little change after sequential adjustment; and AOR 0.34 (0.21–0.73) in the fully adjusted model. The Indigenous cohort had a lower likelihood of psychiatric hospital discharge even after adjustment for variables associated with discharge to the psychiatric hospital highlighting the need for further investigation of the reasons accounting for this differential pattern of clinical management and the effectiveness of differential after-care allocation.
Research Paradigm of Network Approaches in Construction Safety and Occupational Health
Authors: Liu Mei , Li Boning , Cui Hongjun , Liao Pin-Chao , Huang Yuecheng
Published: September 2022

Construction safety accidents seriously threaten the lives and health of employees; however, the complexity of construction safety problems continues to increase. Network approaches have been widely applied to address accident mechanics. This study aims to review related studies on construction safety and occupational health (CSOH) and summarize the research paradigm of recent decades. We solicited 119 peer-reviewed journal articles and performed a bibliometric analysis as the foundation of the future directions, application bottlenecks, and research paradigm. (1) Based on the keyword cluster, future directions are divided into four layers: key directions, core themes, key problems, and important methods. (2) The network approaches are not independently applied in the CSOH research. It needs to rely on different theories or be combined with other methods and models. However, in terms of approach applications, there are still some common limitations that restrict its application and development. (3) The research paradigm of network analysis process can be divided into four stages: description, explanation, prediction, and control. When the same network method encounters different research objects, it focuses on different analysis processes and plays different roles.
Comparison of Pollution Levels, Biomagnification Capacity, and Risk Assessments of Heavy Metals in Nearshore and Offshore Regions of the South China Sea
Authors: Yang Shaochen , Sun Kaifeng , Liu Jinling , Wei Nan , Zhao Xing
Published: September 2022

Seawater and fish were collected from nearshore (Pearl River Estuarine, PRE) and offshore (middle of the South China Sea, MSCS) regions of the South China Sea (SCS) to determine the heavy metals (HMs) pollution status and biomagnification characteristics. Results show that Cu in PRE seawater was moderately contaminated. Overall pollution risk of seawater were PRE (3.32) > MSCS (0.56), whereas that of fish was MSCS (0.88) > PRE (0.42). δ13C and δ15N exhibited distinguished characteristics for PRE and MSCS fish, indicating the diverse energy sources, nitrogen sources, and food web structures of nearshore and offshore regions. Cu was biomagnified whereas Pb and Ni were biodiluted in offshore fish. Hg presented significant biomagnification in both of nearshore and offshore fish. Finally, the target hazard quotient of Hg (1.41) in MSCS fish exceeded the standard limit, which was posed by high Hg concentration and consumption rate of offshore fish.
The Effect of Boredom on College Students’ Meaning in Life: A Longitudinal Mediation Model
Authors: Li Xushan , Jia Xiaoming
Published: September 2022

Boredom is a common emotional experience in daily life adversely affecting individual physical health, mental health, and social functioning. Therefore, it is an important issue to improve the quality of life by ameliorating individuals’ state of boredom. We used a longitudinal research approach. First, we tested 728 participants with the Multidimensional State Boredom Scale (MSBS). Then, after 3 months, the participants filled out the Cognitive Flexibility Inventory (CFI), Perceived Social Support Scale (PSSS), and Meaning of Life Questionnaire (MILQ); 715 valid questionnaires were obtained. Results showed that cognitive flexibility played a mediating role between boredom and the presence of meaning in life, but social support did not. The total effect of boredom on the presence of meaning in life was significant. Cognitive flexibility and social support played a mediating role between boredom and the search for meaning in life, respectively, but the overall effect of boredom on the search for meaning in life was not significant. This study found that boredom has different effects on the presence of meaning in life and the search for meaning in life. It can improve individuals’ sense of meaning in life by reducing boredom and improving cognitive flexibility and social support.
Patient Experiences after Physical Trauma: The Negative Effect of the COVID-19 Pandemic on Recovery
Authors: Finstad Jeanette , Clausen Thomas , Rosseland Leiv Arne , Røise Olav , Havnes Ingrid A.
Published: September 2022

The coronavirus disease 2019 (COVID-19) pandemic generated a crisis within the healthcare system, during which acute, COVID-19-related health needs were prioritized over less urgent needs, including vulnerable subgroups. This study explored experiences of recovery among survivors of physical injuries associated with severe pain during the COVID-19 pandemic in Norway. In-depth interviews were conducted among 13 participants. Findings generated by a thematic analysis revealed that the pandemic, including the contagion control measures and interrupted healthcare, were of negative consequence for the participants’ recovery experiences and mental and physical health. Despite experiencing severe pain and perceived needs for support, the participants experienced being deprioritized by the healthcare system. They experienced a reduced capacity to cope with pandemic-related stress and to perform everyday tasks, which they perceived as generating an additional burden for their loved ones. Alcohol was reported to be used in an effort to relieve the associated mental distress. As suggested by this study, injury survivors constitute a vulnerable subgroup for whom the continuity of rehabilitation services during a national crisis, as well as the integration of mental health support, can be essential for mitigating the negative impact of the crisis on recovery and for promoting optimal long-term health outcomes.
Policy Evaluation of Demonstration Cooperative Construction: Evidence from Sichuan Province, China
Authors: Chen Rui , Khan Nawab , Zhang Shemei
Published: September 2022

Agricultural cooperatives are professional organizations that increase farmers’ incomes through market failure corrections, livelihood resilience, and sustainable rural development. The main purpose of this paper was to evaluate the policy effects of the construction of demonstration cooperatives for farmers in China. The authors of this paper used the propensity score matching (PSM) method to evaluate the policy effect of the construction of demonstration cooperatives based on questionnaire survey data on 509 farmer cooperatives in 10 counties in Sichuan Province of China. On this basis, the inverse probability weighting-regression adjustment (IPWRA) method was used as a robustness test. The authors of this study were the first to systematically and comprehensively assess the policy effects of demonstration cooperatives while considering selectivity effects. The empirical results show that the Chinese government’s construction of demonstration cooperatives has significant policy effects, especially regarding policy support in improving the economic strength, service capacity, product quality, and social response of demonstration cooperatives. However, the policy effect of improving the democratic management of cooperatives is not significant. It is recommended that the government continue to strengthen policy support in improving the economic strength, service capacity, product quality, and social response of demonstration cooperatives. Simultaneously, more effective measures should be taken to promote the democratic management of model cooperatives.
Oral Health in 12- and 15-Year-Old Children in Serbia: A National Pathfinder Study
Authors: Peric Tamara , Campus Guglielmo , Markovic Evgenija , Petrovic Bojan , Soldatovic Ivan , Vukovic Ana , Kilibarda Biljana , Vulovic Jelena , Markovic Jovan , Markovic Dejan
Published: September 2022

The aim of the paper is to present the oral health profile of 12- and 15-year-old schoolchildren in Serbia. Basic Methods for Oral Health Surveys of the WHO were implemented to record: Decayed, Missing, and Filled Teeth/Surfaces Index (DMFT/DMFS), gingival bleeding, enamel fluorosis and other structural anomalies, dental erosion, dental trauma, and oral mucosal lesions. In addition, Silness and Löe plaque index and orthodontic status were assessed. A total of 36% of 12-year-olds and 22% of 15-year-olds in Serbia were caries-free. The mean DMFT was 2.32 ± 2.69 for 12-year-olds and 4.09 ± 3.81 for 15-year-olds. DMFT was made up largely by the decayed component. Gingival bleeding was present in 26% of examined 12-year-old and 18% of 15-year-old children. Dental plaque was observed in 63% of both 12- and 15-year-olds. Fluorosis, structural anomalies, dental erosion, dental trauma, and oral mucosal lesion were rarely detected. Low prevalence of malocclusions was found. Oral disease is still a common public health problem among schoolchildren in Serbia. A significant increase in the prevalence of caries disease between 12- and 15-year-old groups implies that preventive care for adolescents requires special attention. Corrective actions and reforms to the current school-based oral health prevention program are needed to further improve oral health in Serbian children.
Effect of Seat Angle when Sleeping in a Car on Quality of Sleep and Its Impact on Calculation Performance the Following Day
Authors: Ogata Hitomi , Nishikawa Tomohiro , Kayaba Momoko , Kaneko Miki , Ogawa Keiko , Kiyono Ken
Published: September 2022

The number of occasions to stay in a car overnight is increasing during disasters; however, the effects on sleep and the impact on daytime functioning are not well understood. We investigated the effect of seat angle when sleeping in a car and its impact on calculation performance the following day. Fifteen healthy males participated in three trials (sleeping in a car with the front seat angled at 45° and 60° in a laboratory and sleeping at home); sleep and calculation performance the following day were compared. Increased wake after sleep onset and decreased slow-wave sleep were observed in the 60° trial, that is, near-vertical, compared with the others. Subjective sleep quality and calculation performance in the 45° and 60° trials were poorer than those in the home trial. The effect of seat angle on sleep was confirmed objectively, but not subjectively, suggesting that a large seat angle might cause sleep impairment.