bluuebunny/crossref_metadata_2025 huggingface dataset:
Guided-acoustic stimulated Brillouin scattering in silicon nitride photonic circuits
Authors: Botter Roel , Ye Kaixuan , Klaver Yvan , Suryadharma Radius , Daulay Okky , Liu Gaojian , van den Hoogen Jasper , Kanger Lou , van der Slot Peter , Klein Edwin , Hoekman Marcel , Roeloffzen Chris , Liu Yang , Marpaung David
Published: October 2022

Coherent optomechanical interaction known as stimulated Brillouin scattering (SBS) can enable ultrahigh resolution signal processing and narrow-linewidth lasers. SBS has recently been studied extensively in integrated waveguides; however, many implementations rely on complicated fabrication schemes. The absence of SBS in standard and mature fabrication platforms prevents its large-scale circuit integration. Notably, SBS in the emerging silicon nitride (Si
3
N
4
) photonic integration platform is currently out of reach because of the lack of acoustic guidance. Here, we demonstrate advanced control of backward SBS in multilayer Si
3
N
4
waveguides. By optimizing the separation between two Si
3
N
4
layers, we unlock acoustic waveguiding in this platform, potentially leading up to 15× higher Brillouin gain coefficient than previously possible in Si
3
N
4
waveguides. We use the enhanced SBS gain to demonstrate a high-rejection microwave photonic notch filter. This demonstration opens a path to achieving Brillouin-based photonic circuits in a standard, low-loss Si
3
N
4
platform.
BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors
Authors: Itahashi Kota , Irie Takuma , Yuda Junichiro , Kumagai Shogo , Tanegashima Tokiyoshi , Lin Yi-Tzu , Watanabe Sho , Goto Yasushi , Suzuki Jun , Aokage Keiju , Tsuboi Masahiro , Minami Yosuke , Ishii Genichiro , Ohe Yuichiro , Ise Wataru , Kurosaki Tomohiro , Suzuki Yutaka , Koyama Shohei , Nishikawa Hiroyoshi
Published: October 2022

Regulatory T (T
reg
) cells suppress effective antitumor immunity in tumor-bearing hosts, thereby becoming promising targets in cancer immunotherapy. Despite the importance of T
reg
cells in tumor immunity, little is known about their differentiation process and epigenetic profiles in the tumor microenvironment (TME). Here, we showed that T
reg
cells in the TME of human lung cancers harbored a completely different open chromatin profile compared with CD8
+
T cells, conventional CD4
+
T cells in the TME, and peripheral T
reg
cells. The integrative sequencing analyses including ATAC, single-cell RNA, and single-cell ATAC sequencing revealed that BATF, IRF4, NF-κB, and NR4A were important transcription factors for T
reg
cell differentiation in the TME. In particular, BATF was identified as a key regulator, which leveraged T
reg
cell differentiation through epigenetically controlling activation-associated gene expression, resulting in the robustness of T
reg
cells in the TME. The single-cell sequencing approaches also revealed that tissue-resident and tumor-infiltrating T
reg
cells followed a common pathway for differentiation and activation in a BATF-dependent manner heading toward T
reg
cells with the most differentiated and activated phenotypes in tissues and tumors. BATF deficiency in T
reg
cells remarkably inhibited tumor growth, and high BATF expression was associated with poor prognosis in lung cancer, kidney cancer, and melanoma. These findings indicate one of the specific chromatin remodeling and differentiation programs of T
reg
cells in the TME, which can be applied in the development of T
reg
cell–targeted therapies.
Evolution of antigen-specific follicular helper T cell transcription from effector function to memory
Authors: Robinson Amanda M. , Higgins Brett W. , Shuparski Andrew G. , Miller Karen B. , McHeyzer-Williams Louise J. , McHeyzer-Williams Michael G.
Published: October 2022

Understanding how follicular helper T cells (TFH) regulate the specialization, maturation, and differentiation of adaptive B cell immunity is crucial for developing durable high-affinity immune protection. Using indexed single-cell molecular strategies, we reveal a skewed intraclonal assortment of higher-affinity T cell receptors and the distinct molecular programming of the localized TFH compartment compared with emigrant conventional effector T
H
cells. We find a temporal shift in B cell receptor class switch, which permits identification of inflammatory and anti-inflammatory modules of transcriptional programming that subspecialize TFH function before and during the germinal center (GC) reaction. Late collapse of this local primary GC reaction reveals a persistent post-GC TFH population that discloses a putative memory TFH program. These studies define subspecialized antigen-specific TFH transcriptional programs that progressively change with antibody class-specific evolution of high-affinity B cell immunity and a memory TFH transcriptional program that emerges upon local GC resolution.
A new tolerogenic cell RORs onto the scene
Authors: Olyha Sam J. , Eisenbarth Stephanie C.
Published: October 2022

Differentiation of microbe-specific T
regs
in the gut is directed by RORγt
+
antigen–presenting cells.
GTP-Bound Escherichia coli FtsZ Filaments Are Composed of Tense Monomers: a Dynamic Nuclear Polarization-Nuclear Magnetic Resonance Study Using Interface Detection
Authors: McCoy Kelsey M. , Fritzsching Keith J. , McDermott Ann E.
Published: October 2022

Bacterial replication is dependent on the cytoskeletal protein FtsZ, which forms filaments that scaffold and recruit other essential division proteins. While the FtsZ monomer is well studied across organisms, many questions remain about how the filaments form and function.
Draft Genome Sequences of Seven
Limosilactobacillus fermentum
Indigenously Isolated Probiotic Strains from the Artisanal Fermented Milk Product Dahi
Authors: Khan Muhammad Nadeem , Imran Muhammad
Published: October 2022

Here, we report the draft genome sequences of seven strains of potentially probiotic
Limosilactobacillus fermentum
isolated from the traditional fermented milk product dahi. The estimated average genome size was 1,955,815 bp, with a median GC content of 52%. Genome annotation predicted an average of 1,871 protein-coding genes and 47 RNAs.
Draft Genome Sequence of the Yeast Torulaspora quercuum Strain UCD657, Isolated from Soil in Ireland
Authors: Igharo Blessing , Byrne Kevin P. , Ghnewa Heytham , Davey Ryan P. , Fubara Athaliah , Welc Julia , Oubihi Shafik , Moore Luke , Smith Cian , Ó Cinnéide Eoin , Bergin Sean A. , Hession Conor , Wolfe Kenneth H. , Butler Geraldine
Published: October 2022

Torulaspora quercuum
is an ascomycete yeast first isolated in 2009. Here, we present the genome sequence of
T. quercuum
isolate UCD657, which was isolated from soil in Ireland. This genome is 10.4 Mb and was assembled into 8 chromosome-sized scaffolds of >1 Mb in size, plus a mitochondrial genome scaffold.
Isolation of an Extensively Drug-Resistant Pseudomonas aeruginosa
exoS
+
/O4 Strain Belonging to the “High-Risk” Clone ST654 and Coproducer of NDM-1 and the Novel VIM-80
Authors: Opazo-Capurro Andrés , Morales-León Felipe , Jerez Christian , Olivares-Pacheco Jorge , Alcalde-Rico Manuel , González-Muñoz Paulina , Bello-Toledo Helia , Cardenas-Arias Adriana , Esposito Fernanda , Lincopán Nilton , Illesca Vijna , González-Rocha Gerardo
Published: October 2022

The aim of this study was to investigate the genomic features of an extensively drug-resistant (XDR)
Pseudomonas aeruginosa
isolate (P-469) emerging in Chile. Antibiotic susceptibility was determined by disk diffusion and “colistin agar” test.
Diversity and trends of human milk banking: a scoping review from 1946 to 2021
Authors: Siziba Linda P , Huhn Sebastian , Pütz Elisabeth , Baier Caroline , Peter Raphael S , Gebauer Corinna , Griffin Samantha , Wedekind Sophie , Shenker Natalie , Genuneit Jon
Published: October 2022

Background

The provision of donor human milk (DHM) through human milk banks is now widely practised globally. The study aimed to describe the current state, identify major topics and map out the emerging trends in human milk banking.

Methods

PubMed was systematically searched for publications related to DHM, with the last update on 14 May 2021, for papers published between 1946 and 2021. Titles and abstracts were screened and indexed into 8 main and 39 subcategories. A top-up search was done in April 2022, but these results have not been incorporated.

Results

A total of 1083 publications were identified, and more than a third (41%) were either observational or interventional studies. Predominant topics were milk type and milk composition. Almost half (49%) of the publications in the last decade were funded through government/research councils, and industry funding started shortly after links between formula and necrotising enterocolitis were published. Literature from high-income countries was six times more than publications from low-income or middle-income countries (LMICs).

Conclusion

The diversity and trends of publications included in this scoping review ranged from descriptive studies comparing biological and compositional differences of mother’s own milk, DHM and/or formula. Very few studies have investigated associations of different milk types with infant outcomes. Evidence on breastfeeding and recipient psychological health outcomes is limited. Further research should identify the appropriateness of different funding sources. Future collaborations between academics, clinicians and milk banks in LMICs should be fostered to bridge the gap that exists between DHM and access.
Solitary fibrous tumour of the pleura: a rare cause of digital clubbing
Authors: Vekaria Bina Devji , Myerson James , Routledge Thomas , Zhang Ting Ting
Published: October 2022

A woman in her early 70s was found to have incidental finger clubbing at a fracture clinic consultation for an unrelated problem. She reported no associated respiratory symptoms and was referred back to her General Practitioner for further investigation. A chest radiograph revealed a large left-sided mass. This was characterised as a pleural-based mass on CT, resulting in localised atelectasis and mediastinal shift. A CT guided biopsy revealed histology consistent with a solitary fibrous tumour of the pleura and the patient was referred for thoracotomy and resection.
Influence of the frame of reference on head acceleration events recorded by instrumented mouthguards in community rugby players
Authors: Bussey Melanie Dawn , Davidson Peter , Salmon Danielle , Romanchuk Janelle , Tong Darryl , Sole Gisela
Published: October 2022

Objectives

To highlight the need for standardisation in the communication of head impact telemetry from instrumented mouthguards (iMG). The purpose of this study is to examine how the frame of reference for reporting head acceleration events (HAE) may affect the interpretation of head impacts recorded from iMGs in community rugby players.

Methods

An analytical investigation of 825 video verified HAEs recorded from male community players during 5 rugby match exposures. HAEs were captured with an iMG, known to be reliable and valid for this purpose. The linear and angular head acceleration at the centre of mass (head_CG) was calculated from filtered iMG accelerometer and gyroscope data, and the location of impact was estimated. The iMG and head_CG data were examined for systematic bias, geometric differences and the degree of concordance. Finally, mixed model analyses were fitted to assess the differences in peak resultant acceleration (PLA) by impact locations and directions of head motion while controlling for intra-athlete correlations.

Results

The degree of concordance between the iMG versus head_CG measures varied by impact location. The mixed model confirmed differences in the PLA by location (F(8,819)= 16.55, p<0.001) and by direction of head motion (F(5,417)= 7.78, p<0.001).

Conclusion

The head acceleration reported at the iMG is not proportional to measurements that have been transformed to the head_CG. Depending on the impact location and direction of head motion, the acceleration measured at the iMG may overestimate, underestimate or miss entirely the PLA with respect to the head_CG. We recommend standardising the reporting of iMG data within the head_CG frame of reference.
Reduced humoral response to a third dose (booster) of SARS-CoV-2 mRNA vaccines by concomitant methotrexate therapy in elderly patients with rheumatoid arthritis
Authors: Stahl David , tho Pesch Carola , Brück Carolin , Esser Ruth L , Thiele Jan , Di Cristanziano Veronica , Kofler David M
Published: October 2022

Background

Several health authorities recommend a third (booster) vaccination to protect patients with rheumatic and musculoskeletal diseases from severe COVID-19. Methotrexate has been shown to reduce the efficacy of the first and second dose of SARS-CoV-2 mRNA vaccines. So far, it remains unknown how concomitant methotrexate affects the efficacy of a COVID-19 booster vaccination.

Methods

We compared the humoral immune response to SARS-CoV-2 vaccination in 136 patients with rheumatoid arthritis (RA) treated with methotrexate and/or biological or targeted synthetic (b/tsDMARDs). IgG targeting the receptor binding domain (RBD) of SARS-CoV-2 spike protein was measured at a median of 52.5 (range 2–147) days after a third dose of the SARS-CoV-2 mRNA vaccines BNT162b2 or mRNA-1273.

Results

Anti-RBD IgG was significantly reduced in elderly patients receiving concomitant treatment with methotrexate as compared with elderly patients receiving monotherapy with b/tsDMARDs or methotrexate (64.8 (20.8, 600.3) binding antibody units per mL (BAU/mL) vs 1106.0 (526.3, 4965.2) BAU/mL vs 1743.8 (734.5, 6779.6) BAU/mL, median (IQR), p<0.001, Kruskal-Wallis test). In younger patients (< 64.5 years), concomitant methotrexate had no significant impact on the humoral immune response.

Conclusions

Concomitant methotrexate increases the risk of an insufficient humoral immune response to SARS-CoV-2 vaccination in elderly patients with RA. Pausing methotrexate during the third vaccination period may be considered for this group of patients.
NOTCH2NLCexpanded GGC repeats in patients with cerebral small vessel disease
Authors: Wang Yun-chao , Fan Yu , Yu Wen-Kai , Shen Si , Li Jia-Di , Gao Yuan , Ji Yan , Li Yu-Sheng , Yu Lu-Lu , Zhao Zi-Chen , Li Shan-Shan , Ding Yao , Shi Chang-He , Xu Yu-ming
Published: October 2022

Objective

GGC repeat expansions in the human-specificNOTCH2NLCgene have been reported as the cause of neuronal intranuclear inclusion disease (NIID). Given the clinical overlap of cognitive impairment in NIID and cerebral small vessel disease (CSVD), both diseases have white matter hyperintensity on T2-fluid-attenuated inversion recovery sequences of brain MRI, and white matter hyperintensity is a primary neuroimaging marker of CSVD on MRI. Therefore, we hypothesised that the GGC repeat expansions might also contribute to CSVD. To further investigate the relationship betweenNOTCH2NLCGGC repeat expansions and CSVD, we performed a genetic analysis of 814 patients with the disease.

Methods

We performed a comprehensive GGC repeat expansion screening inNOTCH2NLCfrom 814 patients with sporadic CSVD. Their Fazekas score was greater than or equal to 3 points. Repeat-primed PCR and fluorescence amplicon length analyses were performed to identify GGC repeat expansions, and whole-exome sequencing was used to detect any pathogenic mutation in previously reported genes associated with CSVD.

Results

We identified nine (1.11%) patients with pathogenic GGC repeat expansions ranging from 41 to 98 repeats. The minor allele frequency of expanded GGC repeats inNOTCH2NLCwas 0.55%.

Conclusion

Our findings suggest that intermediate-length and longer-length GGC repeat expansions inNOTCH2NLCare associated with sporadic CSVD. This provides new thinking for studying the pathogenesis of CSVD.
Utilization of grape (Vitis vinifera), cranberry (Vaccinium macrocarpon), wild blueberry (Vaccinium angustifolium), and apple (Malus pumila/domestica) pomaces in broiler chickens when fed without or with multi-enzyme supplement
Authors: Kithama Munene , Ross Kelly , Diarra Moussa S. , Kiarie Elijah G.
Published: October 2022

Nutritive and functional values of fruit pomaces in poultry are unexplored. We determined apparent metabolizable energy (AME) and plasma metabolites in broiler chickens fed diets containing apple (APL), low-bush wild blueberry (LBP), cranberry (CRP), and grape (GRP) pomaces without or with multi-enzyme supplement (ENZ). A total of 360 one-day old Ross 708 male chicks were placed in 72 cages; 5 birds/cage were reared to day 13 and transitioned to either cornstarch–soy protein isolate basal diet or basal with 30% of either pomace without or with ENZ. Excreta samples were collected from day 17 to 20 and one bird/cage bled for plasma metabolites on day  21. Apple pomace showed a higher AME ( P = 0.008) than other pomaces; however, ENZ had no effect on AME. The AMEs were 3 250, 2 613, 2 394, and 3 008  kcal/kg DM for APL, LBP, CRP, and GRP, respectively. There was pomace and ENZ interaction on plasma alkaline phosphatase ( P = 0.04), and APL increased cholesterol levels ( P < 0.01). In conclusion, ENZ had no impact on energy increment in pomaces, but the AME values this study has established are nonetheless valuable for accurate poultry feed formulation. Plasma metabolites suggested pomace components are amenable to supplemental ENZ.
Are epicuticular waxes a surface defense comparable to trichomes? A test using two Solanum species and a specialist herbivore
Authors: Watts Sakshi , Kariyat Rupesh
Published: October 2022

Although plants possess a suite of structural defenses, most studies have focused on trichomes. Trichomes can have both pre- and post-ingestive effects and have been consistently found to reduce herbivory. Along with trichomes, a few studies have focused on epicuticular waxes as an important defense; however, manipulated comparisons examining herbivore growth and development are limited. In this study, using two Solanum species ( Solanum glaucescens Zuccarini and Solanum macrocarpon Linnaeus) that vary in both defenses, we tested the hypothesis that variation in defenses will affect herbivore feeding, primarily by restricting feeding commencement. We used electron microscopy together with a series of plant- and diet-based manipulative experiments, using tobacco hornworm ( Manduca sexta Linnaeus; Lepidoptera: Sphingidae) as the herbivore. We found that Solanum glaucescens leaves had significantly fewer trichomes and significantly higher wax content when compared to Solanum macrocarpon. We also found that Solanum glaucescens waxes acted as a strong physical barrier resulting in lower mass gain and higher mortality of caterpillars compared to Solanum macrocarpon. Artificial diet manipulation experiments also suggested the possible toxicity of waxes. Collectively, we show that epicuticular waxes can play a significant role as a strong surface barrier and should be examined further.
Numerical solutions to the fractional-order wave equation
Authors: Khader M. M. , Inc Mustafa , Adel M. , Akinlar M. Ali
Published: October 2022

New numerical solution to the linear fractional-order wave equation is presented. The Liouville–Caputo sense fractional-derivative operator and Crank–Nicholson finite difference method (CN-FDM) algorithm are employed. The stability of the present technique is considered by the fractional Von Neumann stability analysis method. Special example as an application of the method is provided. The obtained results are examined to check the derived stability condition of the proposed algorithm. Computational results indicate that the present numerical algorithm is efficient and applicable for the problem under study and many other problems.
Framework for QCA Layout Generation and Rules for Rotated Cell Design
Authors: Kumaresan Raja Sekar , Raj Marshal , Gopalakrishnan Lakshminarayanan
Published: October 2022

Quantum-dot Cellular Automata (QCA) is a nontransistor-based nanotechnology circuit design paradigm. The circuits are implemented by using cells having quantum dots and electrons. There are several cell configurations with varying combinations of electrons and quantum dots. But the widely used cells have the four-dot two-electron structure. Circuits are realized and validated by using QCADesigner. However, the layouts are developed manually by using this tool. Layouts are not entirely automated in QCA. Hence, in this work, the existing QCA tools and the different techniques proposed in the literature to improve the QCA layout generation are analyzed and a complete framework for QCA layout generation is proposed. It also explores the gap that needs to be filled to achieve a reliable CAD tool for QCA layout generation. In addition to that, to design circuits using rotated cells, design rules and cost functions are proposed. Novel circuits of multiplexer and D-flip-flop are also proposed using rotated cells. The proposed designs have better output polarization compared to other designs. Verification is done in QCADesigner.
Boundary layer mesh resolution in flow computation with the Space–Time Variational Multiscale method and isogeometric discretization
Authors: Kuraishi Takashi , Takizawa Kenji , Tezduyar Tayfun E.
Published: October 2022

We present an extensive study on boundary layer mesh resolution in flow computation with the Space–Time Variational Multiscale (ST-VMS) method and isogeometric discretization. The study is in the context of 2D flow past a circular cylinder, at Reynolds number ranging from [Formula: see text] to [Formula: see text]. It was motivated by the need to have in tire aerodynamics a better understanding of the mesh resolution requirements near the tire surface. The focus in the study is on the normal-direction element length for the first layer of elements near the cylinder, with that length varying by a refinement factor ranging from 2 to 40. The evaluation is based mostly on the velocity profile near the cylinder. As the element length for the first layer is varied, the element lengths for the other layers of the disk-shaped inner mesh are adjusted, with no increase in the number of elements for the refinement factors 2, 3, and 4, and with modest increases only in the radial direction for refinement factors beyond that. The computations are performed with quadratic NURBS basis functions in space and linear basis functions in time. The expressions for the stabilization parameters used in the ST-VMS and for the related local lengths scales are those targeting isogeometric discretization, introduced in recent years. The mesh resolution study is based mostly on the strong enforcement of the Dirichlet boundary conditions on the cylinder, but also includes some computations with the weakly-enforced conditions. We expect that the data generated and observations made will be helpful in setting proper near-surface mesh resolution in VMS-based computations with isogeometric discretization, not only for cylindrical shapes but also for comparable geometries. We furthermore expect that although the data generated and observations made are based on computations with nonmoving meshes, they will also be applicable to computations with moving meshes where the mesh around the solid surface rotates with the surface in the framework of the ST Slip Interface method.
Coidempotent graph of a ring
Authors: Razaghi Somayyeh , Sahebi Shervin
Published: October 2022

Let [Formula: see text] be a ring with nonzero identity. The coidempotent graph of [Formula: see text], denoted it by [Formula: see text], has its set of vertices equal to the set of all elements of [Formula: see text]; distinct vertices [Formula: see text] are adjacent in [Formula: see text] if and only if [Formula: see text] or [Formula: see text] is an idempotent of [Formula: see text]. In this paper, we study some basic properties of [Formula: see text] and find some results about the ring-theoretic properties of [Formula: see text] and graph-theoretic properties of [Formula: see text].
Coherent Raman scattering imaging of lipid metabolism in cancer
Authors: Zhang Shuo , He Yexuan , Yue Shuhua
Published: October 2022

Cancer cells dysregulate lipid metabolism to accelerate energy production and biomolecule synthesis for rapid growth. Lipid metabolism is highly dynamic and intrinsically heterogeneous at the single cell level. Although fluorescence microscopy has been commonly used for cancer research, bulky fluorescent probes can hardly label small lipid molecules without perturbing their biological activities. Such a challenge can be overcome by coherent Raman scattering (CRS) microscopy, which is capable of chemically selective, highly sensitive, submicron resolution and high-speed imaging of lipid molecules in single live cells without any labeling. Recently developed hyperspectral and multiplex CRS microscopy enables quantitative mapping of various lipid metabolites in situ. Further incorporation of CRS microscopy with Raman tags greatly increases molecular selectivity based on the distinct Raman peaks well separated from the endogenous cellular background. Owing to these unique advantages, CRS microscopy sheds new insights into the role of lipid metabolism in cancer development and progression. This review focuses on the latest applications of CRS microscopy in the study of lipid metabolism in cancer.
The Democratic Prospects of Digital Urban Futures: Lessons from India’s Smart Cities Mission
Authors: BASU IPSHITA , KALRA RIPIN
Published: October 2022

This paper explains the potential implications of digital interventions for social accountability through the Smart Cities Mission (SCM) in India. The SCM represents India’s transition to a new political economy based on rapid urbanization and wide-scale application of digital technology to reform public service delivery while simultaneously creating new markets for urban transformation. Within this wider context, the paper considers the future of democratic practices in urban governance. We argue that while citizen-led accountability practices were trialed by civil society organizations since 1990s, the SCM presented unique opportunity and challenge to institutionalize these tools within the framework of multi-scalar governance — between central-, state- and local-level institutions and between communities, private vendors and public bodies. Zooming into the four smart city projects — Indore, Kakinada, Panaji and Ranchi — we explain how each city engaged with citizen groups, communities and civil society and what their experiences tell us about the prospects and challenges of democratizing digital urban futures.
Learning Shared Representations for Recommendation with Dynamic Heterogeneous Graph Convolutional Networks
Authors: Jing Mengyuan , Zhu Yanmin , Xu Yanan , Liu Haobing , Zang Tianzi , Wang Chunyang , Yu Jiadi
Published: October 2022

Graph Convolutional Networks (GCNs) have been widely used for collaborative filtering, due to their effectiveness in exploiting high-order collaborative signals. However, two issues have not been well addressed by existing studies. First, usually only one kind of information is utilized, i.e., user preference in user-item graphs or item dependency in item-item graphs. Second, they usually adopt static graphs, which cannot retain the temporal evolution of the information. These can limit the recommendation quality. To address these limitations, we propose to mine three kinds of information (user preference, item dependency, and user behavior similarity) and their temporal evolution by constructing multiple discrete dynamic heterogeneous graphs (i.e., a user-item dynamic graph, an item-item dynamic graph, and a user-subseq dynamic graph) from interaction data. A novel network (PDGCN) is proposed to learn the representations of users and items in these dynamic graphs. Moreover, we designed a structural neighbor aggregation module with novel pooling and convolution operations to aggregate the features of structural neighbors. We also design a temporal neighbor aggregation module based on self-attention mechanism to aggregate the features of temporal neighbors. We conduct extensive experiments on four real-world datasets. The results indicate that our approach outperforms several competing methods in terms of Hit Ratio (HR) and Normalized Discounted Cumulative Gain (NDCG). Dynamic graphs are also shown to be effective in improving recommendation performance.
Fixed-point FPGA Implementation of the FFT Accumulation Method for Real-time Cyclostationary Analysis
Authors: Li Carol Jingyi , Li Xiangwei , Lou Binglei , Jin Craig T. , Boland David , Leong Philip H. W.
Published: October 2022

The spectral correlation density (SCD) is an important tool in cyclostationary signal detection and classification. Even using efficient techniques based on the fast Fourier transform (FFT), real-time implementations are challenging because of the high computational complexity. A key dimension for computational optimization lies in minimizing the wordlength employed. In this article, we analyze the relationship between wordlength and signal-to-quantization noise in fixed-point implementations of the SCD function. A canonical SCD estimation algorithm, the FFT accumulation method (FAM) using fixed-point arithmetic, is studied. We derive closed-form expressions for SQNR and compare them at wordlengths ranging from 14 to 26 bits. The differences between the calculated SQNR and bit-exact simulations are less than 1 dB. Furthermore, an HLS-based FPGA design is implemented on a Xilinx Zynq UltraScale+ XCZU28DR-2FFVG1517E RFSoC. Using less than 25% of the logic fabric on the device, it consumes 7.7 W total on-chip power and has a power efficiency of 12.4 GOPS/W, which is an order of magnitude improvement over an Nvidia Tesla K40 graphics processing unit (GPU) implementation. In terms of throughput, it achieves 50 MS/sec, which is a speedup of 1.6 over a recent optimized FPGA implementation.
Molecular Mechanisms of Winter Survival
Authors: Teets Nicholas M. , Marshall Katie E. , Reynolds Julie A.
Published: October 2022

Winter provides many challenges for insects, including direct injury to tissues and energy drain due to low food availability. As a result, the geographic distribution of many species is tightly coupled to their ability to survive winter. In this review, we summarize molecular processes associated with winter survival, with a particular focus on coping with cold injury and energetic challenges. Anticipatory processes such as cold acclimation and diapause cause wholesale transcriptional reorganization that increases cold resistance and promotes cryoprotectant production and energy storage. Molecular responses to low temperature are also dynamic and include signaling events during and after a cold stressor to prevent and repair cold injury. In addition, we highlight mechanisms that are subject to selection as insects evolve to variable winter conditions. Based on current knowledge, despite common threads, molecular mechanisms of winter survival vary considerably across species, and taxonomic biases must be addressed to fully appreciate the mechanistic basis of winter survival across the insect phylogeny.
COVID‐19: An Accelerator for Global Plastic Consumption and Its Implications
Authors: Choudhury Moharana , Sahoo Subhrajeet , Samanta Palas , Tiwari Arushi , Tiwari Alavya , Chadha Utkarsh , Bhardwaj Preetam , Nalluri Abhishek , Eticha Tolera Kuma , Chakravorty Arghya
Published: October 2022

Plastic has been ingrained in our society. Repercussions on the usage of nonbiodegradable plastics and their problems have been recently realized. Despite its detrimental environmental impact, the COVID‐19 epidemic has compelled worldwide citizens to increase their plastic use due to affordability and availability. The volume of hospital solid waste, particularly plastics, is overgrowing due to an unexpected increase in medical waste, culminating in the global waste management catastrophe. Henceforth, adopting good waste management practices along with appropriate technologies and viewing the current issue from a fresh perspective would be an opportunity in this current scenario. Accordingly, this review study will focus on the plastic waste scenario before and during the COVID‐19 epidemic. This review also disseminates alternative disposal options and recommends practical solutions to lessen human reliance on traditional plastics. Further, the responsibilities of various legislative and regulatory authorities at the local, regional, and worldwide levels are addressed.
Antimicrobial Resistance of Listeria monocytogenes from Animal Foods to First- and Second-Line Drugs in the Treatment of Listeriosis from 2008 to 2021: A Systematic Review and Meta-Analysis
Authors: Dos Reis Jaqueline Oliveira , Vieira Bruno Serpa , Cunha Neto Adelino , Castro Vinicius Silva , Figueiredo Eduardo Eustáquio de Souza
Published: October 2022

First-line drugs for the treatment of listeriosis are the same around the world, but particular conditions might reduce their efficacy, including antimicrobial resistance. Therefore, this study aimed to verify, based on a systematic review and meta-analysis, whether the prevalence of antimicrobial resistance in Listeria monocytogenes from animal foods is higher for first- or second-line antimicrobials. From the total of 302 identified studies, 16 met all the eligibility criteria from 2008 to 2021 and were included in this meta-analysis. They comprised a dataset of 1152 L. monocytogenes isolates, obtained from different animal food products, food processing environment, and live animals. The included studies were developed in South America (n = 5), Europe (n = 4), Asia (n = 3), Africa (n = 2), and North America (n = 2), testing a total of 35 different antimicrobials, 11 of them classified as first-line drugs. Complete lack of antimicrobial resistance across the studies (all L. monocytogenes isolates tested as susceptible) was only observed for linezolid, while widespread antimicrobial resistance (all L. monocytogenes isolates tested resistant) was described for amoxicillin, benzylpenicillin, cefoxitin, fusidic acid, imipenem, sulfamethoxazole, and vancomycin. Overall, the meta-analysis results indicated no evidence that antimicrobial resistance in L. monocytogenes isolated from animal-based food is higher for first-line antimicrobials compared to second-line compounds (

p
=
0.37

). A greater volume of publication, together with better characterization of the isolates, is still needed for a more precise estimate of the real prevalence of antimicrobial resistance in L. monocytogenes.
Mathematical Modeling Methods and Their Application in the Analysis of Complex Signal Systems
Authors: Li Yanjun
Published: October 2022

Mathematical models are effective means of answers established by humans to solve real-world problems. Complex wireless communication can establish information interaction between vehicles, in order to reduce the delay time of the coordination control optimization timing scheme in coordination delay time. For smart car driving, a complex signal system, this study first establishes a relevant mathematical model. It is used to compare three mathematical models commonly used today. The results obtained under the same conditions show that the mathematical model is better in dealing with the complex signal system in terms of transmission accuracy in all segments. A number of vehicles in different states of the traffic system are selected, and the relevant data are collected to plot ROC curves using the mathematical model. It can be concluded that the freer and more complex the movement behavior of the vehicle, the greater the load it imposes on the road and the system. The results of the confusion matrix show that the model can effectively reduce the pressure on the road and the signal system. With the starting objective of smooth operation of public transportation, the target values are optimized by layering, and finally, the regional roadway capacity is effectively converged. Then, the mathematical model optimization of complex wireless systems and intelligent transportation networks is quantitatively evaluated. The optimized timing scheme through coordinated control achieves the expected effect in coordinated control of delay time and also reduces the average delay time of all intersections of the road network.
Extremely High Primary Productivity and Organic Matter Enrichment in Lacustrine Sediments: Late Triassic Chang 73 Sub-Member, Western Ordos Basin
Authors: Liao Zhiwei , Wu Zigang , Chen Qiang , Zhang Yi , Wang Xiaodong , Liu Yunqian , Xu Zhijie
Published: October 2022

The 7th member of the Late Triassic Yanchang Formation is the most important Mesozoic source rocks and shale oil reservoir in the Ordos Basin. The hydrocarbon potential and organic matter enrichment mechanism of this organic-rich member are questioned because of the high heterogeneity of continental sediments. In particular, the lack of drilling in the Chang 73 sub-member of the western Ordos Basin (central Tianhuan Depression) hinders this understanding and the progress of shale oil exploration in this region. In this study, 87 samples were collected from the well DP1 in the Tianhuan Depression, western Ordos Basin, and analyzed for sedimentology and geochemistry to unravel the paleoenvironment, paleo-productivity, and hydrocarbon potential of the Chang 73 sub-member. The results show that the Chang 73 shale is characterized by ultra-high organic matter abundance (up to 10.60%), type II kerogen, and good hydrocarbon generation potential. An intermediate chemical weathering intensity suggests that this set of organic-rich shale was deposited in a warm and humid paleoclimate setting. Extreme organic matter enrichment in study area may be attributed to ultra-high productivity (hypereutrophic lake), superimposed terrigenous organic matter input, and transgression, rather than volcanism and anoxic bottom water. This model is different from those of Chang 73 interval with higher organic matter content in the central and southern parts of the Ordos Basin. Therefore, this study proposes that the Chang 73 shale in the central Tianhuan Depression is not a good target layer for shale oil exploration and that the favorable area may be located in an undisturbed deep lake with higher organic matter abundance (e.g., southwestern Ordos Basin).
LINC00958 Inhibits Autophagy of Bladder Cancer Cells via Sponge Adsorption of miR-625-5p to Promote Tumor Angiogenesis and Oxidative Stress
Authors: Xiao Ying , Wang Tao , Cheng Xiao , Liu Fangwen , Wu You , Ma Limin , Li Wenguang
Published: October 2022

Objective. This study further explored LINC00958’s role in promoting tumor angiogenesis (AG) and oxidative stress (OS) development by inhibiting BC cell autophagy through sponge adsorption of miR-625-5p. Methods. BC patients and healthy controls who visited our hospital between June 2017 and February 2019 were selected as the research group (RG) and the control group (CG), respectively, with a total of 133 study subjects. Peripheral blood LINC00958 and miR-625-5p in both cohorts of participants were detected. Additionally, human bladder transitional cell carcinoma cells (T24 and J82) and human normal urothelial cells (SV-HUC-1) were purchased. Alterations in cell biological behavior were observed after transfecting miR-625-5p-mimics, miR-625-5p-inhibition, and miR-625-5p-NC sequences into these cells, respectively. Besides, ELISA was performed to quantify inflammatory factors (IFs), AG indicators, and OS indexes in cells. Subsequently, a double luciferase reporter (DLR) assay was performed to verify the targeting relationship between LINC00958 and miR-625-5p. Finally, BALB/c-nu nude mice were purchased, and T24 cells transfected with silenced LINC00958 and miR-625-5p expression sequences were used to establish subcutaneous tumors to observe tumor growth and pathological changes. Results. RG exhibited higher LINC00958 and lower miR-625-5p than CG. LINC00958 and miR-625-5p were strongly linked to myometrial invasion (MI), lymph node metastasis (LNM), distant metastasis (DM), and histology in BC patients, and the increase of LINC00958 and the decrease of miR-625-5p predicted an increased risk of prognostic death in such patients. After miR-625-5p inhibition, the capacity of BC cells to proliferate, invade, and migrate enhanced and the AG, inflammatory response, and OS injury increased, while the apoptosis rate and autophagy ability decreased. The DLR assay revealed inhibited LINC00958WT fluorescence activity by miR-625-5p-mimics, while the biological behavior of BC cells cotransfected with sh-LINC00958 and miR-625-5p-inhibition had no difference with the functions of sh-control and miR-625-5p-NC cotransfected cells. Finally, the nude mouse tumorigenesis experiment showed that the tumor mass, volume, and histopathological features of the sh-LINC00958 group were decreased compared with the sh-control group, while those of the miR-625-5p-inhibition group were increased versus miR-625-5p-NC. Conclusions. In BC, LINC00958 is highly expressed while miR-625-5p is underexpressed. LINC00958 can inhibit cell autophagy to enhance cell activity; promote OS, inflammation, and AG; and regulate tumor immunity by targeting miR-625-5p, thus participating in the development of BC.
Power Quality Improvement in a Solar PV Assisted Microgrid Using Upgraded ANN-Based Controller
Authors: Albert Alexander S. , Harish R. , Srinivasan M. , Sarathkumar D.
Published: October 2022

This paper proposes the design of a controller using the artificial neural network (ANN) for a solar photovoltaic (PV)-fed cascaded multilevel inverter (CMLI) to enhance the power quality. The objective of this presented ANN controller is to obtain a maximum output voltage with no filter components. This paper also investigates and eliminates the voltage harmonics that occurred in a solar-fed cascaded 3-stage inverter using various techniques such as pulse width modulation (PWM), digital logic control (DLC), fuzzy logic controller (FLC), and ANN, and the results are compared. Based on the results, the proposed ANN-based controller efficiently reduces harmonics and improves the power quality. This is achieved by solving the harmonic equations and thereby changing the switching angles of each semiconductor to a minimum value. The ANN is trained by a dataset consisting of varying input voltage and switching angles. The simulation was performed using MATLAB/Simulink for different types of controllers like PWM, DLC, FLC, and ANN for the 3-stage inverter. The simulated results are compared with the results obtained from a 3 kWp photovoltaic plant connected to the CMLI. Finally, on the basis of performance analysis, it was confirmed that the ANN-based controller effectively eliminates harmonics and improves the power quality.
[Retracted] Effect of MTHFRC677 T Gene Polymorphism on Early Morning Blood Pressure in Elderly Female Patients with H‐Type Hypertension
Authors: Zhang Chi , Li Jun , Zhou Jian , Zheng Qiaoling , Dong Ruicong , Xing Enhong , Dou Zhijie
Published: October 2022

The distribution characteristics of Methylenetetrahydrofolate Reductase (MTHFR) gene C677 T polymorphism and its influence on early morning blood pressure in elderly female patients with H‐type hypertension are investigated. A total of 220 elderly female patients with hypertension who received diagnosis and treatment in our hospital from March to September 2021 are selected. All patients received serum index detection in our hospital and are grouped according to blood homocysteine (Hcy) level. Patients with Hcy>10 μmol/L are classified as H‐type hypertension and included in H‐type hypertension group (n = 166). Patients with Hcy≤10 μmol/L are included in the non‐H‐type hypertension group (n = 54). Both groups underwent 24‐hour ambulatory blood pressure monitoring. Base frequency and allele distribution of MTHFR gene C677 T locus are compared between the two groups, and the relationship between different bases of MTHFR gene C677 T locus and morning blood pressure and Hcy level is analyzed. The risk factors of morning hypertension in patients with H‐type hypertension are analyzed by binary logistic regression. Binary logistic regression analysis shows that smoking history, drinking history, high‐salt diet, MTHFR gene C677 T genotype, and abnormal 24 h systolic blood pressure are the risk factors for the occurrence of morning hypertension in H‐type hypertension patients. The frequency of TT homozygous mutation at the C677 T site of the MTHFR gene is high in patients with H‐type hypertension, and the mutation of the C677 T site of the MTHFR gene had an effect on systolic blood pressure and Hcy level.
Efficacy of Acupuncture Combined with Patient-Controlled Analgesia in the Treatment of Acute Pain after Back Surgery: A Meta-Analysis
Authors: Deng Daling , Xu Feng , Wang Yafeng , Ma Lulin , Zhang Tianhao , Zhao Wenjing , Chen Xiangdong
Published: October 2022

Objectives. Acupuncture is used worldwide to relieve both acute and chronic pain. Patient-controlled analgesia (PCA) is also frequently used for postoperative pain relief. However, there are few meta-analyses of the efficacy of acupuncture with PCA in reducing acute postoperative pain. This meta-analysis aimed to assess the effectiveness of acupuncture with PCA in relieving acute pain after back surgery. Methods. We searched seven databases (Cochrane Library, Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), Wanfang database, Chongqing VIP (VIP), and Chinese BioMedical Literature Database (CBM)-from 1949 until now) without language restrictions for randomized controlled trials, including patients undergoing back surgery and receiving PCA alone or treated with acupuncture/sham acupuncture + PCA for pain relief. This meta-analysis assessed pain intensity, with visual analogue scale (VAS) score and postoperative opioid dosage as primary outcomes. Results. A total of 12 randomized controlled trials (n = 904) met the inclusion criteria. Compared with the control group (standard mean difference (SMD) = ‒0.42, 95% CI = ‒0.60 to ‒0.25,

P
<
0.01

) or sham acupuncture + PCA (SMD = ‒0.7, 95% CI = ‒0.94 to ‒0.46,

P
<
0.01

), acupuncture + PCA treatment reduced the VAS score in patients after back surgery. Acupuncture + PCA decreased the use of opioids after surgery compared to sham acupuncture + PCA (SMD = −0.35, 95% CI = ‒0.63 to ‒0.07,

P
=
0.01

) or control group (SMD = ‒0.82, 95% CI = ‒1.03 to ‒0.61,

P
<
0.01

). Furthermore, the use of acupuncture with PCA reduced the incidence of postoperative PCA-related total complications (odds ratio = 0.44, 95% CI = 0.23 to 0.85,

P
=
0.01

), but may not reduce the incidence of postoperative nausea and vomiting (odds ratio =0.82 , 95% CI =0.49 to 1.36,

P
=
0.44

). Conclusion. This systematic review found that acupuncture with PCA relieved acute pain after back surgery more effectively than PCA alone and could reduce opioid use and the incidence of postoperative PCA-related total complications