bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Racial/Ethnic Representation in Select Basic and Applied Cancer Research Studies
Authors: Guerrero Santiago , López-Cortés Andrés , Indacochea Alberto , García-Cárdenas Jennyfer M. , Zambrano Ana Karina , Cabrera-Andrade Alejandro , Guevara-Ramírez Patricia , González Diana Abigail , Leone Paola E. , Paz-y-Miño César
Published: September 2018

Over the past decades, consistent studies have shown that race/ethnicity have a great impact on cancer incidence, survival, drug response, molecular pathways and epigenetics. Despite the influence of race/ethnicity in cancer outcomes and its impact in health care quality, a comprehensive understanding of racial/ethnic inclusion in oncological research has never been addressed. We therefore explored the racial/ethnic composition of samples/individuals included in fundamental (patient-derived oncological models, biobanks and genomics) and applied cancer research studies (clinical trials). Regarding patient-derived oncological models (n = 794), 48.3% have no records on their donor’s race/ethnicity, the rest were isolated from White (37.5%), Asian (10%), African American (3.8%) and Hispanic (0.4%) donors. Biobanks (n = 8,293) hold specimens from unknown (24.56%), White (59.03%), African American (11.05%), Asian (4.12%) and other individuals (1.24%). Genomic projects (n = 6,765,447) include samples from unknown (0.6%), White (91.1%), Asian (5.6%), African American (1.7%), Hispanic (0.5%) and other populations (0.5%). Concerning clinical trials (n = 89,212), no racial/ethnic registries were found in 66.95% of participants, and records were mainly obtained from Whites (25.94%), Asians (4.97%), African Americans (1.08%), Hispanics (0.16%) and other minorities (0.9%). Thus, two tendencies were observed across oncological studies: lack of racial/ethnic information and overrepresentation of Caucasian/White samples/individuals. These results clearly indicate a need to diversify oncological studies to other populations along with novel strategies to enhanced race/ethnicity data recording and reporting.
Serum miR-331-3p predicts tumor recurrence in esophageal adenocarcinoma
Authors: Gu Jianchun , Zhang Jinhua , Zheng Leizhen , Ajani Jaffer A. , Wu Xifeng , Ye Yuanqing
Published: September 2018

MicroRNAs (miRNAs) may contribute to the initiation and progression of cancer. The role of circulating miRNAs as predictors of recurrence in esophageal adenocarcinoma (EAC) has not been extensively explored. Here we measured the expressions of 167 miRNAs in serum samples from a discovery cohort of 72 EAC patients (32 patients with recurrence and 40 patients without). A rank sum test was performed to identify differentially expressed miRNAs. Cox regression model was applied to estimate the effect of miRNA expression on recurrence-free survival. The eligible miRNAs were then validated in an independent cohort of 329 EAC patients (132 patients with recurrence and 197 patients without). miR-331-3p was identified and confirmed to be differentially expressed between EAC patients with and without recurrence and associated with recurrence-free survival. In both cohorts, the expression of miR-331-3p was consistently decreased in patients with recurrence compared to those without (P < 0.05). Using patients with low expression of miR-331-3p as reference, those with high expression had HRs for recurrence of 0.45 (95% CI, 0.21-0.96, P = 0.040) and 0.55 (95% CI, 0.38–0.78, P = 0.001) in the discovery and validation cohorts, respectively. Therefore, serum miR-331–3p may be a useful biomarker for identifying EAC patients at high risk of recurrence.
A high content, small molecule screen identifies candidate molecular pathways that regulate rod photoreceptor outer segment renewal
Authors: Campbell Leah J. , West Megan C. , Jensen Abbie M.
Published: September 2018

The outer segment of the vertebrate rod photoreceptor is a highly modified cilium composed of many discrete membranous discs that are filled with the protein machinery necessary for phototransduction. The unique outer segment structure is renewed daily with growth at the base of the outer segment where new discs are formed and shedding at the distal end where old discs are phagocytized by the retinal pigment epithelium. In order to understand how outer segment renewal is regulated to maintain outer segment length and function, we used a small molecule screening approach with the transgenic (hsp70:HA-mCherryTM) zebrafish, which expresses a genetically-encoded marker of outer segment renewal. We identified compounds with known bioactivity that affect five content areas: outer segment growth, outer segment shedding, clearance of shed outer segment tips, Rhodopsin mislocalization, and differentiation at the ciliary marginal zone. Signaling pathways that are targeted by the identified compounds include cyclooxygenase in outer segment growth, γ-Secretase in outer segment shedding, and mTor in RPE phagocytosis. The data generated by this screen provides a foundation for further investigation of the signaling pathways that regulate photoreceptor outer segment renewal.
Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats
Authors: Bakshi Ishita , Brown Simon H. J. , Brandon Amanda E. , Suryana Eurwin , Mitchell Todd W. , Turner Nigel , Cooney Gregory J.
Published: September 2018

Increased lipid metabolism in muscle is associated with insulin resistance and therefore, many strategies have been employed to alter fatty acid metabolism and study the impact on insulin action. Metabolism of fatty acid requires activation to fatty acyl CoA by Acyl CoA synthases (ACSL) and fatty acyl CoA can be hydrolysed by Acyl CoA thioesterases (Acot). Thioesterase activity is low in muscle, so we overexpressed Acot7 in muscle of chow and high-fat diet (HFD) rats and investigated effects on insulin action. Acot7 overexpression modified specific phosphatidylcholine and phosphatidylethanolamine species in tibialis muscle of chow rats to levels similar to those observed in control HFD muscle. The changes in phospholipid species did not alter glucose uptake in tibialis muscle under hyperinsulinaemic/euglycaemic clamped conditions. Acot7 overexpression in white extensor digitorum longus (EDL) muscle increased complete fatty acid oxidation ex-vivo but was not associated with any changes in glucose uptake in-vivo, however overexpression of Acot7 in red EDL reduced insulin-stimulated glucose uptake in-vivo which correlated with increased incomplete fatty acid oxidation ex-vivo. In summary, although overexpression of Acot7 in muscle altered some aspects of lipid profile and metabolism in muscle, this had no major effect on insulin-stimulated glucose uptake.
Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest
Authors: Belužić Lucija , Grbeša Ivana , Belužić Robert , Park Jong Hoon , Kong Hyun Kyung , Kopjar Nevenka , Espadas Guadalupe , Sabidó Eduard , Lepur Adriana , Rokić Filip , Jerić Ivanka , Brkljačić Lidija , Vugrek Oliver
Published: September 2018

Recently, functional connections between S-adenosylhomocysteine hydrolase (AHCY) activity and cancer have been reported. As the properties of AHCY include the hydrolysis of S-adenosylhomocysteine and maintenance of the cellular methylation potential, the connection between AHCY and cancer is not obvious. The mechanisms by which AHCY influences the cell cycle or cell proliferation have not yet been confirmed. To elucidate AHCY-driven cancer-specific mechanisms, we pursued a multi-omics approach to investigate the effect of AHCY-knockdown on hepatocellular carcinoma cells. Here, we show that reduced AHCY activity causes adenosine depletion with activation of the DNA damage response (DDR), leading to cell cycle arrest, a decreased proliferation rate and DNA damage. The underlying mechanism behind these effects might be applicable to cancer types that have either significant levels of endogenous AHCY and/or are dependent on high concentrations of adenosine in their microenvironments. Thus, adenosine monitoring might be used as a preventive measure in liver disease, whereas induced adenosine depletion might be the desired approach for provoking the DDR in diagnosed cancer, thus opening new avenues for targeted therapy. Additionally, including AHCY in mutational screens as a potential risk factor may be a beneficial preventive measure.
West Nile virus transmission and human infection risk in Veneto (Italy): a modelling analysis
Authors: Marini Giovanni , Rosà Roberto , Pugliese Andrea , Rizzoli Annapaola , Rizzo Caterina , Russo Francesca , Montarsi Fabrizio , Capelli Gioia
Published: September 2018

An intensified and continuous West Nile virus (WNV) spread across northern Italy has been observed since 2008, which caused more than one hundred reported human infections until 2016. Veneto is one of the Italian regions where WNV is considered endemic, and the greatest intensity of circulation was observed during 2013 and 2016. By using entomological data collected across the region in those years, we calibrated a temperature-driven mathematical model through a Bayesian approach that simulates the WNV infection in an avian population with seasonal demography. We considered two alternative routes of life cycle re-activation of the virus at the beginning of each vector breeding season: in the first one the virus is maintained by infected birds, in the other by diapausing mosquitoes previously infected. Afterwards, we computed seasonal risk curves for human infection and quantified how they translate into reported symptomatic cases. According to our results, WNV is more likely to be re-activated each year via previously infected mosquitoes. The highest probability of human infection is expected to occur in August, consistently with observations. Our epidemiological estimates can be of particular interest for public health authorities, to support decisions in term of designing efficient surveillance plans and preventive measures.
Cryptic introgression: evidence that selection and plasticity mask the full phenotypic potential of domesticated Atlantic salmon in the wild
Authors: Glover Kevin A. , Solberg Monica F. , Besnier Francois , Skaala Øystein
Published: September 2018

Domesticated Atlantic salmon grow much faster than wild salmon when reared together in fish tanks under farming conditions (size ratios typically 1:2–3). In contrast, domesticated salmon only display marginally higher growth than wild salmon when reared together in rivers (size ratios typically 1:1–1.2). This begs the question why? Is this a difference in the plastic response driven by divergent energy budgets between the two environments, or is it a result of selection, whereby domesticated salmon that display the greatest growth-potential are those at greatest risk of mortality in the wild? We reared domesticated, hybrid and wild salmon in a river until they smoltified at age 2 or 4, and thereafter in fish tanks for a further 2 years. In the river, there was no difference in the mean size between the groups. In contrast, after being transferred from the river to fish tanks, the domesticated salmon significantly outgrew the wild salmon (maximum size ratio of ~1:1.8). This demonstrates that selection alone cannot be responsible for the lack of growth differences observed between domesticated and wild salmon in rivers. Nevertheless, the final size ratios observed after rearing in tanks were lower than expected in that environment, thus suggesting that plasticity, as for selection, cannot be the sole mechanism. We therefore conclude that a combination of energy-budget plasticity, and selection via growth-potential mortality, cause the differences in growth reaction norms between domesticated and wild salmon across these contrasting environments. Our results imply that if phenotypic changes are not observed in wild populations following introgression of domesticated conspecifics, it does not mean that functional genetic changes have not occurred in the admixed population. Clearly, under the right environmental conditions, the underlying genetic changes will manifest themselves in the phenotype.
Portable combination of Fourier transform infrared spectroscopy and differential mobility spectrometry for advanced vapor phase analysis
Authors: Hagemann L. Tamina , McCartney Mitchell M. , Fung Alexander G. , Peirano Daniel J. , Davis Cristina E. , Mizaikoff Boris
Published: September 2018

Designing mobile devices for the analysis of complex sample mixtures containing a variety of analytes at different concentrations across a large dynamic range remains a challenging task in many analytical scenarios.
Correction: ATR-FTIR spectroscopy with chemometric algorithms of multivariate classification in the discrimination between healthy vs. dengue vs. chikungunya vs. zika clinical samples
Authors: Santos Marfran C. D. , Nascimento Yasmin M. , Monteiro Joelma D. , Alves Brenda E. B. , Melo Marília F. , Paiva Anne A. P. , Pereira Hannaly W. B. , Medeiros Leandro G. , Morais Ingryd C. , Fagundes Neto João Ciro , Fernandes José V. , Araújo Josélio M. G. , Lima Kássio M. G.
Published: September 2018

Correction for ‘ATR-FTIR spectroscopy with chemometric algorithms of multivariate classification in the discrimination between healthy vs. dengue vs. chikungunya vs. zika clinical samples’ by Marfran C. D. Santos et al., Anal. Methods, 2018, 10, 1280–1285.
Enzyme-immobilized metal–organic framework nanosheets as tandem catalysts for the generation of nitric oxide
Authors: Ling Pinghua , Qian Caihua , Gao Feng , Lei Jianping
Published: September 2018

An enzyme-immobilized metal–organic framework nanosystem was developed as a tandem catalyst for in situ generation of nitric oxide in serum samples.
Two-electron oxidation of a homoleptic U(iii) guanidinate complex by diphenyldiazomethane
Authors: Settineri Nicholas S. , Shiau Angela A. , Arnold John
Published: September 2018

Use of a new homoleptic U(iii) tris-guanidinate system stabilizes the formation of the first U(v) hydrazido complex.
Nucleation and crystal growth of barium sulfate: inhibition in the presence of rigid and flexible triphosphonate additives
Authors: Athanasopoulos Evangelos D. , Armakola Eirini , Koutsoukos Petros G. , Demadis Konstantinos D.
Published: September 2018

The influence of two triphosphonate additives (flexible and rigid) on the crystallization of barite has been evaluated.
Effects of various morphologies on the optical and electrical properties of boehmite nanostructures
Authors: Roy Shubham , Maity Anupam , Mandal Paulami , Chanda Dipak Kr. , Pal Kunal , Bardhan Souravi , Das Sukhen
Published: September 2018

This work reports the variations in the fluorescence and ultra-high dielectric properties of various boehmite nano-structures.
Revealing the roles of solvation in D-mannitol's polymorphic nucleation
Authors: Liu Shiyuan , Xu Shijie , Tang Weiwei , Yu Bo , Hou Baohong , Gong Junbo
Published: September 2018

Using the different solvating powers of solvents, molecular distribution within solutions can be changed, leading to distinct solvation patterns that ultimately affect polymorphic outcomes.
Zwitterion formation and subsequent carboxylate–pyridinium NH synthon generation through isomerization of 2-anilinonicotinic acid
Authors: Yue Pengyun , Dong Caiqiao , Zhang Mingtao , Xu Danrui , Parkin Sean , Li Tonglei , Li Conggang , Yu Faquan , Long Sihui
Published: September 2018

Structural isomerization of 2-anilinonicotinic acids to 4-anilinonicotinic acids leads to an increase of ΔpKa, thus leading to the formation of a carboxylate–pyridinium NH dimer in the solid state.
Flexible colloidal nanocrystal electronics
Authors: Kagan Cherie R.
Published: September 2018

Colloidal nanocrystals are dispersed in solvent forming “inks” for the solution-based fabrication of flexible nanocrystal electronics.
Current advances in the catalytic conversion of carbon dioxide by molecular catalysts: an update
Authors: Tappe Nadine A. , Reich Robert M. , D'Elia Valerio , Kühn Fritz E.
Published: September 2018

Recent advances (2015–) in the catalytic conversion of CO2 by metal-based and metal-free systems are discussed.
The synergistic effect of layered double hydroxides with other flame retardant additives for polymer nanocomposites: a critical review
Authors: Liu Yuan , Gao Yanshan , Wang Qiang , Lin Weiran
Published: September 2018

The current synergistic effect and mechanism between LDHs and other flame retardant additives for polymers are summarized.
The effect of conformational isomerism on the optical properties of bis(8-oxyquinolato) diboron complexes with a 2,2′-biphenyl backbone
Authors: Urban Mateusz , Górka Patrycja , Nawara Krzysztof , Woźniak Krzysztof , Durka Krzysztof , Luliński Sergiusz
Published: September 2018

The effect of molecular conformation on the luminescence properties of two sterically congested diboron complexes with 8-oxyquinolato ligands is studied.
A La3+-selective metallohydrogel with a facile gelator of a phenylalanine derivative containing an imidazole group
Authors: Wei Chuan-Wan , Wang Xiao-Juan , Gao Shu-Qin , Wen Ge-Bo , Lin Ying-Wu
Published: September 2018

The first La3+-selective metallohydrogel was successfully constructed by using a facile gelator of a phenylalanine derivative containing an imidazole group, namely La-ImF.
A call to (green) arms: a rallying cry for green chemistry and engineering for CO2 capture, utilisation and storage
Authors: Leclaire Julien , Heldebrant David J.
Published: September 2018

Chemists, engineers, scientists, lend us your ears… Carbon capture, utilisation, and storage (CCUS) is among the largest challenges on the horizon and we need your help.
Controlled photo-flow oxidative reaction (UV-FOR) platform for ultra-fast phthalide and API synthesis
Authors: Aand Dnyaneshwar , Karekar Sanjeev , Mahajan Bhushan , Pawar Amit B. , Singh Ajay K.
Published: September 2018

A time-efficient, integrated and continuous-flow platform has been developed for real-time, high-throughput studies on phthalide and API synthesis from ketone–O2 reactions.
Efficient electroreduction of CO2 to C2 products over B-doped oxide-derived copper
Authors: Chen Chunjun , Sun Xiaofu , Lu Lu , Yang Dexin , Ma Jun , Zhu Qinggong , Qian Qingli , Han Buxing
Published: September 2018

B-Doped oxide-derived-Cu achieves the total faradaic efficiency of 48.2% for C2 products via stabilizing Cu+ species.
Diffusion–reaction kinetics of microfluidic amperometric biosensors
Authors: Li Hui , Lu Yi , Wong Pak Kin
Published: September 2018

A combined experimental and numerical study reveals the dynamics and kinetics of microfluidic amperometric biosensors for bacterial detection.
Effect of surface/interfacial defects on photo-stability of thick-shell CdZnSeS/ZnS quantum dots
Authors: Huang Bo , Yang Hongyu , Zhang Lei , Yuan Yufen , Cui Yiping , Zhang Jiayu
Published: September 2018

In this report, we mainly discussed the influence of surface/interfacial defects on the exciton recombination in CdZnSeS/ZnS QDs with different shell thicknesses by spectroelectrochemical and ultraviolet irradiation experiments.
Velcro-mimicking surface based on polymer loop brushes
Authors: Zhou Tian , Han Biao , Qi Hao , Pan Qiwei , Smith Derrick M. , Han Lin , Li Christopher Y.
Published: September 2018

A Velcro-mimicking surface based on well-defined polymer loop brushes was fabricated using a polymer single crystal-assisted grafting-to method.
Study of the mechanoluminescence and ‘aggregation-induced emission enhancement’ properties of a new conjugated oligomer containing tetraphenylethylene in the backbone: application in the selective and sensitive detection of explosive
Authors: Dineshkumar Sengottuvelu , Laskar Inamur Rahaman
Published: September 2018

D–π-A based ‘Aggregation-Induced Emission Enhancement (AIEE)’ active conjugated oligomer (oTPETP) exhibits an abnormal blue shifting mechanoluminescence and selective and sensitive detection of explosive.
The contribution of Eu3+ doping concentration on the modulation of morphology and luminescence properties of InVO4:Eu3+
Authors: Li Yinyan , Xu Shiqing
Published: September 2018

Nanomaterials of InVO4 and InVO4:Eu3+ were synthesized, and their morphology and luminescent properties could be modulated by Eu3+ ion doping concentration.
Insight into the adsorption of a liquid organic hydrogen carrier, perhydro-i-dibenzyltoluene (i = m, o, p), on Pt, Pd and PtPd planar surfaces
Authors: Moro Ouma Cecil Naphtaly , Modisha Phillimon , Bessarabov Dmitri
Published: September 2018

Liquid organic hydrogen carrier (LOHC) interaction with a planar surface of a catalyst.
Electrostatically regulated photoinduced electron transfer in “cationic” eco-friendly CuInS2/ZnS quantum dots in water
Authors: Ann Maria Xavier Jewel , Devatha Gayathri , Roy Soumendu , Rao Anish , Pillai Pramod P.
Published: September 2018

An artificial light harvesting system based on cationic eco-friendly CuInS2 QDs as efficient electron donors, in water, is presented.
Templated synthesis of a 1D Ag nanohybrid in the solid state and its organized network for strain-sensing applications
Authors: Liu Jize , Guo Quanquan , Mao Shizhe , Chen Zhenming , Zhang Xu , Yang Yibo , Zhang Xinxing
Published: September 2018

Solvent-free synthesis of a templated 1D Ag nanohybrid and its assembled organized network for strain-sensing applications.
Intermolecular interactions in molecular crystals and their effect on thermally activated delayed fluorescence of helicene-based emitters
Authors: Klimash Anastasia , Pander Piotr , Klooster Wim T. , Coles Simon J. , Data Przemyslaw , Dias Fernando B. , Skabara Peter J.
Published: September 2018

In crystals of donor–acceptor helicene molecules, thermally activated delayed fluorescence (TADF) is strongly enhanced by the presence of occluded hexane molecules.
Communicative Accessibility in Aphasia: An Investigation of the Interactional Context of Long-Term Care Facilities
Authors: Azios Jamie H. , Damico Jack S. , Roussel Nancye
Published: September 2018

Purpose

The purpose of this study was to examine the ability of persons with aphasia to access interaction and be included in social encounters in long-term care facilities (LTCFs).

Method

Four persons with aphasia were the focus of this investigation. A qualitative research approach using ethnographic methods was used to conduct participant observation, semistructured interviews, and artifact analysis. Expanded field notes from observations, transcribed interviews, and artifacts were then coded to identify patterns in the data.

Results

The interactional context of LTCFs negatively influenced the ability of persons with aphasia to communicate with others and develop meaningful relationships. Three major themes emerged from the data detailing the contextual elements leading to communication accessibility and inclusion: (a) lack of support, (b) social hierarchy, and (c) focus on performance.

Conclusions

Findings highlighted several barriers in LTCFs that worked to discourage persons with aphasia from living social and expressive lives. Specific obstacles included a misunderstanding of aphasia and its influence on communicative exchanges and performance-oriented environment that overlooked psychosocial needs. Speech-language pathologists have an important role for advocacy in LTCFs. Clinical implications for assessment and treatment in institutions are discussed.
Read, Understand, Learn, & Excel (RULE): Development and Feasibility of a Reading Comprehension Measure for Postsecondary Learners
Authors: Kucheria Priya , Sohlberg McKay Moore , Yoon HyeonJin , Fickas Stephen , Prideaux Jason
Published: September 2018

Purpose

There is a lack of quick, reliable, and valid standardized reading comprehension assessments appropriate for postsecondary readers. We attempted to address this gap by designing Read, Understand, Learn, & Excel (RULE), a reading comprehension measure that employs sentence verification and recall tasks to assess reading comprehension. This article describes the exploratory study undertaken to construct RULE and then examines the preliminary concurrent validity and alternate form reliability of this measure.

Method

The RULE measure was first developed by designing reading stimuli, test items for the sentence verification task, and directions for the recall test for 2 forms based on previous work (Griffiths, Sohlberg, Kirk, Fickas, & Biancarosa, 2016). Thirty undergraduate students who identified themselves as typical readers were administered the RULE measure as well as the Nelson–Denny Reading Test (Brown, Fishco, & Hanna, 1993). Students also completed questionnaires and participated in informal interviews to provide information regarding study and learning habits and academic background.

Results

There was preliminary evidence of alternate form reliability between the sentence verification task sets of 2 chapters of RULE (
r
= .38,
p
< .05). Preliminary evidence for concurrent validity between RULE and the Nelson–Denny Reading Test was provided by correlation coefficients in the low to moderate range (.03–.38).

Conclusion

RULE design and preliminary findings of concurrent validity and alternate form reliability provide “proof of concept” for an ecologically valid testing format that assesses comprehension skills appropriate for the postsecondary level. Suggestions for strengthening validity and reliability of the tool are provided, and clinical contributions of RULE are discussed.

Supplemental Material

https://doi.org/10.23641/asha.6987371
Information Content and Efficiency in the Spoken Discourse of Individuals With Parkinson's Disease
Authors: Roberts Angela , Post Danielle
Published: September 2018

Purpose

This study compared the information content and information efficiency of spoken language in individuals with Parkinson's disease (PD) to a healthy comparator group.

Method

Nineteen participants with PD and 19 healthy older adults completed the prospective, cross-sectional study. In the primary analysis, 2 language samples elicited by standardized protocols were analyzed for group differences using standard discourse informativeness measures including main events (MEs; Wright, Capilouto, Wagovich, Cranfill, & Davis, 2005) analyzed as %MEs and correct information units (CIUs; Nicholas & Brookshire, 1993) analyzed as %CIUs and CIUs/min. In exploratory analyses, the following were examined: (a) associations among conceptual (%MEs) and lexical (%CIUs and CIUs/min) measures and (b) associations among informativeness measures and age, education, disease severity/duration, global cognition, speech intelligibility, and a verb confrontation naming measure.

Results

In the primary analysis, the PD group differed significantly from the control group on conceptual (%MEs) and lexical measures of content (%CIUs) and efficiency (CIUs/min). In exploratory analyses, for the control group %MEs were significantly correlated with CIUs/min. Significant associations among conceptual and lexical measures of informativeness were not found in the PD group. For controls, there were no significant correlations between informativeness measures and any of the demographic or speech/cognitive/language variables. In the PD group, there was a significant and positive association between CIUs/min and Dementia Rating Scale–Second Edition scores (Mattis, 2001). A significant but negative correlation was found between CIUs/min and motor severity scores. However, %MEs and verb naming were significantly and positively correlated.

Conclusions

Individuals with PD without dementia demonstrated reduced discourse informativeness that reflects disruptions to both conceptual and lexical discourse processes. In exploratory analyses, reduced efficiency of information content was associated with global cognition and motor severity. Clinical and research implications are discussed within a Cognitivist framework of discourse production (Sheratt, 2007).
Enhancement of electrical characteristics of a‐ZTO TFTs based on channel layers produced with alternating precursor concentration
Authors: Uprety S. , Hanggi D. , Yapabandara K. , Mirkhani V. , Khanal M.P. , Schoenek B. , Dhar S. , Park M. , Hamilton M. , Wang S. , Hames W.E. , Sk M.H.
Published: September 2018

The enhancement in electrical characteristics of the thin film transistors (TFTs) based on the mixed‐stacked amorphous zinc tin oxide (a‐ZTO) with an alternating precursor concentration is reported. The channel layers were deposited via sol–gel on oxidised p‐Si. The source/drain ohmic contacts were prepared on the ZTO layer, constructing the bottom‐gate TFTs. In this investigation, the TFTs with the following three channel layers were fabricated, and their characteristics were compared; (i) four layers produced from 0.05 M precursor solution, (ii) four layers produced from 0.2 M precursor solution, and (iii) four layers with alternating 0.05 and 0.2 M precursor solutions. It was found that the mobility (5.3 cm2/V s) of the TFT fabricated with the channel layers with alternating precursor concentration was higher than those with single concentration. Although the mechanism for this mobility enhancement is still being further analysed, it was conjectured that alternating precursor concentration might have reduced the trap density in the transistor channel and/or ZTO/SiO2 interfaces.
Controlled synthesis and characteristics of large‐area and high‐filling nickel nanowires arrays in AAO template
Authors: Lv Xiaoyi , Hou Junwei , Gao Zhixian , Chen An‐di , Ma Yue , Yuan Liang
Published: September 2018

The regular and uniform size of nickel nanowires arrays has been successfully fabricated inside the nanochannels of anodic aluminium oxide (AAO) template by a simple paired cell method. The morphology, composition and structure of the nanowire arrays were characterised by field emission scanning electron microscopy, X‐ray diffraction and transmission electron microscopy. The results show that Ni nanowires possess smooth surface and high aspect ratio up to 15 with a diameter of 70–80 nm. Nearly 100% of the pores were filled by Ni nanowires, which have face centre cubic structure and [111] preferential orientation. Magnetisation measurement revealed that the nickel nanowires arrays have a unique soft magnetic property with small coercivity (Hc) of 11.38 Oe. A 3D self‐seed nucleation coalescent process was proposed for the formation of nickel nanowires structures. The simple synthetic route is expected to be applied to the synthesis of other highly ordered metal nanowires arrays.
The global sphere reconstruction (GSR)
Authors: Vecchiato A. , Bucciarelli B. , Lattanzi M. G. , Becciani U. , Bianchi L. , Abbas U. , Sciacca E. , Messineo R. , De March R.
Published: September 2018

Context.TheGaiaESA mission will estimate the astrometric and physical data of more than one billion objects, providing the largest and most precise catalog of absolute astrometry in the history of astronomy. The core of this process, the so-called global sphere reconstruction, is represented by the reduction of a subset of these objects which will be used to define the celestial reference frame. As the HIPPARCOSmission showed, and as is inherent to all kinds of absolute measurements, possible errors in the data reduction can hardly be identified from the catalog, thus potentially introducing systematic errors in all derived work.

Aims.Following up on the lessons learned from HIPPARCOS, our aim is thus to develop an independent sphere reconstruction method that contributes to guarantee the quality of the astrometric results without fully reproducing the main processing chain.

Methods.Indeed, given the unfeasibility of a complete replica of the data reduction pipeline, an astrometric verification unit (AVU) was instituted by theGaiaData Processing and Analysis Consortium (DPAC). One of its jobs is to implement and operate an independent global sphere reconstruction (GSR), parallel to the baseline one (AGIS, namely Astrometric Global Iterative Solution) but limited to the primary stars and for validation purposes, to compare the two results, and to report on any significant differences.

Results.Tests performed on simulated data show that GSR is able to reproduce at the sub-μas level the results of the AGIS demonstration run.

Conclusions.Further development is ongoing to improve on the treatment of real data and on the software modules that compare the AGIS and GSR solutions to identify possible discrepancies above the tolerance level set by the accuracy of theGaiacatalog.
Surface waves in protoplanetary disks induced by outbursts: Concentric rings in scattered light
Authors: Schneider A. D. , Dullemond C. P. , Bitsch B.
Published: September 2018

Context. Vertically hydrostatic protoplanetary disk models are based on the assumption that the main heating source, stellar irradiation, does not vary much with time. However, it is known that accreting young stars are variable sources of radiation. This is particularly evident for outbursting sources such as EX Lupi and FU Orionis stars.

Aims. We investigate how such outbursts affect the vertical structure of the outer regions of the protoplanetary disk, in particular their appearance in scattered light at optical and near-infrared wavelengths.

Methods. We employ the 3D FARGOCA radiation-hydrodynamics code, in polar coordinates, to compute the time-dependent behavior of the axisymmetric disk structure. The temperature is computed self-consistently and time-dependently from the irradiation flux using a two-stage radiative transfer method: first the direct illumination is computed; then the diffuse radiation is treated with the flux-limited diffusion method. The outbursting inner disk region is not included explicitly. Instead, its luminosity is added to the stellar luminosity and is thus included in the irradiation of the outer disk regions. For time snapshots of interest we insert the density structure into the RADMC-3D radiative transfer code and compute the appearance of the disk at optical/near-infrared wavelengths, where we observe stellar light that is scattered off the surface of the disk.

Results. We find that, depending on the amplitude of the outbursts, the vertical structure of the disk can become highly dynamic, featuring circular surface waves of considerable amplitude. These “hills” and “valleys” on the disk’s surface show up in the scattered light images as bright and dark concentric rings. Initially these rings are small and act as standing waves, but they subsequently lead to outward propagating waves, like the waves produced by a stone thrown into a pond. These waves continue long after the actual outburst has died out.

Conclusions. Single, periodic, or quasiperiodic outbursts of the innermost regions of protoplanetary disks will necessarily lead to wavy structures on the surface of these disks at all radii. We propose that some of the multi-ringed structures seen in optical/infrared images of several protoplanetary disks may have their origin in outbursts that occurred decades or centuries ago. However, the multiple rings seen at (sub-)millimeter wavelengths in HL Tau and several other disks are not expected to be related to such waves.
Representations of cyclically ordered semigroups
Authors: Rosjanuardi Rizky , Yusnitha Isnie , Gozali Sumanang Muhtar
Published: September 2018

SupposeGis a group. We equip the groupGwith a cyclic order in such a way so thatP(G), the positive cone under the cyclic order ofGis a semigroup.We construct a representation of the semigroupP(G) as isometries acting on a certainHilbert space.
Low cost digitalization of observation telescope by utilizing smartphone
Authors: Sohib Ahmad , Danusaid Niko , Sawitri Astri , Nuryadin Bebeh Wahid , Agustina Rena Denya
Published: September 2018

Digitalization of telescopes used as learning media observation of the object is quite effective. However, the cost of operating this system becomes one of the obstacles. The approach to overcome the obstacle can be conducted by utilization of the present technology such as smartphone. Physical experiments have been conducted on the design of digitalization of the starter binoculars interfacing to Personal Computer (PC) using a smartphone. This experiment is aimed to design a more efficient digitalization of telescope observations. Smartphone stative is made in such a way that the camera in the right position on the telescope lens. Data retrieval is taken by a smartphone camera and ASI120MC camera as a comparison parameter. The data will be sent to the PC via an application installed both on smartphone and PC attributed by Bluetooth network. The camera is supported with a camera stative to keep it apart from binoculars. The observations obtained from this system is an interpretation between the camera on the telescope and PC. Such interpretations may produce images or videos observed by telescopes. This design can simplify the interfacing of telescope resulting good enough photo quality.
Preliminary study of simple methods to get the average speed using a smartphone's light sensor
Authors: Mahen Ea Cahya Septia , Susanti Seni , Nuryadin Bebeh Wahid , Nuryantini Ade Yeti
Published: September 2018

This paper reports on the result of a preliminary study of utilization of a smartphone ambient light sensor for get the average speeds of motion along a straight line based on experiments. We attach a smartphone to a dynamics train that travels across multiple light sources where the distance is already set. The main source of this experiment is obtained from the luminosity curve obtained from free android applications. From the curve, we can get position information against time. So from the data we can get the value of average speed. Then the use of the smartphone light sensor in physics experiments can be done easily and fun.
Ozone application to extend shelf life of vegetables by microbial growth inhibition
Authors: Susan A I , Sasmita E , Yulianto E , Arianto F , Restiwijaya M , Kinandana A W , Nur M
Published: September 2018

Ozone has been used to extend the shelf life of vegetables by inhibiting the decomposing microbial growth. The study was conducted using six types of vegetables; i.e. broccoli, tomato, mustard, celery, leek, and lettuce; treated and stored using ozonation techniques. The six types of vegetables were divided into two treatment groups, i.e. ozone-washed and not washed, and stored in ozone-filled cold storage at a dose of 15 gr/m3 per day. Total microbial testing was performed to determine the number of microbes in each vegetable sample. In addition, proximate testing was performed to observe the decreasing rate in nutrient content during storage time. The results showed that ozone-washed tomatoes is the most durable varieties which can stay fresh until day-12 with TPC and YMC values of 4.8x105 CFU/g and 13x105 CFU/g respectively. While the control tomato has a TPC and YMC value of 2.0x106 CFU/g and 85x106 CFU/g respectively. In addition, the proximate test results showed that the nutrient content in each ozone-washed samples didn't decrease significantly compared with the control samples. These results indicate that ozone-washing treatment can extend the shelf life of vegetables while still maintaining their nutritional value.
Analysis of Plasma-activated Medium (PAM) in aqueous solution by an Atmospheric Pressure Plasma Jet (APPJ)
Authors: Kinandana Andi Wibowo , Sumariyah Sumariyah , Nur Muhammad
Published: September 2018

Plasma-activated medium (PAM) has been produced by exposing a liquid media to Argon plasma jet. The jet plasma exposure to liquid media has produced reactive Oxygen species (ROS) in liquid phase. This study aims to determine the number of reactive species in plasma-activated medium. An atmospheric pressure plasma jet (APPJ) was generated with a dielectric barrier discharge (DBD) column by AC high voltage. Some parameters varied including exposure time; i.e. 5, 10, 15, 20, 25, and 30 min; and the distance between reactor and active media; i.e. 1, 2 and 3 cm. Some analysis conducted including variation of exposure times, the distances of reactor to PAM which affect produced concentration, and the reactive species composition in plasma-activated medium. In addition, temperature characteristics, pH levels, dissolved ozone and dissolved hydrogen peroxide concentrations were also observed in this study. The results showed that increased exposure time resulted in decreased pH, increased temperature and increased concentrations of ozone and hydrogen peroxide. The maximum reactive species composition was obtained at the distance between reactor and plasma-activated medium of 2 cm. Maximum reactive species composition obtained in this study has temperature of 29-30 Celsius degrees; pH 3.5; dissolved ozone 2.97 ppm; and Hydrogen Peroxide 215 ppm.
Structural change of aluminum thin film in the temperature range from 300 K to 1000 K
Authors: Fahdiran Riser , Handoko Erfan , Sugihartono Iwan , Susila Anggara Budi , Budi Esmar , Budi Setia
Published: September 2018

We study the structural change of Aluminum thin film due to heat treatment. The film is heated up from room temperature of 300 K to 1000 K where it is already above melting temperature of Aluminum. Molecular dynamics simulation is employed to observe the behavior of the system since it provides atomistic detail. The structural transformation is investigated based on the structure factor and pair distribution function which indicated the broadening of the peak of crystal structure due to phase transition of the material. Atomistic information revealed the local lattice structure change based on Common Neighbor Analysis (CNA) methods.
Comparison of principal component analysis algorithm and local binary pattern for feature extraction on face recognition system
Authors: Taufik Ichsan , Musthopa Maya , Atmadja Aldy Rialdy , Ramdhani Muhammad Ali , Gerhana Yana Aditia , Ismail Nanang
Published: September 2018

Characteristic extraction in face recognition is a step to get characteristic information from the image. The characteristic extraction algorithm is tested against several scenarios of different sunlight and lights, objects facing the camera and not facing the camera. The sample test data were performed on 4 people using a video file or frame numbering 70 for recognizable faces using Principal Component Analysis (PCA) and Local Binary Pattern (LBP) algorithms. The result of the research shows that Local Binary Pattern (LBP) algorithm in object scenario facing camera with sunlighting in room has accuracy of 98.59%, recognition time of 812,817 milliseconds, FAR of 1,41% and FRR of 0%, while at Principal Component Analysis (PCA) 98.59% accuracy, recognition time of 1275,761 milliseconds, FAR of 1.41% and FRR of 0%. Based on these results, the Local Binary Pattern (LBP) algorithm is more efficient than Principal Component Analysis (PCA) for face recognition of the scenarios to be implemented in real-time video.
SPADA: Online learning between universities of PGRI Indonesia
Authors: Hudha Muhammad Nur , Chaeruman Uwes Anis , Aji Sudi Dul , Huda Choirul , Yusro Andista Candra , Kumala Farida Nur , Wartono Wartono , Nandiyanto Asep Bayu Dani , Abdullah Ade Gafar
Published: September 2018

The blended learning model is a learning that uses online facilities combined with face-to-face learning (synchronous learning-asynchronous learning). The purpose of this research is to develop online learning that can be used by two PGRI universities in Indonesia as an online learning media. This research applies research and development method 4D Thiagarajan (Define, Design, Develop, and Disseminate). Data analysis technique used is descriptive qualitative data analysis. The result of this study is an online learning system that can be used by Universitas Kanjuruhan Malang and Universitas PGRI Madiun in Basic Physics course. This system uses the MOODLE (Modular Object-Oriented Dynamic Learning Environment), therefore it has the advantage that it is easy to use by all lecturers.
Congklak, a traditional game solution approach with breadth first search
Authors: Rahim Robbi , Kurniasih Nuning , Hasibuan Abdurrozzaq , Andriany Liesna , Najmurrokhman Asep , Supriyanto S , Wardayani W , Hidayat Rahmat , Lubis D S W , Napitupulu Darmawan , Nugraha Anggara Trisna , Siburian Henry Kristian , Abdullah Dahlan
Published: September 2018

Congklak is a favorite populist game played at least 2 (two) players or in this article were human user and computer (AI). An essential point of playing congklak is to collect as many congklak seeds as possible to win the game, to win form from congklak it need a technique and it’s different for each players. Breadth First Search algorithm is a search algorithm which process to visit each node and the neighbors node to generate optimal graph that gives the best solution to computer (AI) and in this case were to complete the congklak game. Breadth First Search algorithm could be uses an alternative solution for optimal solution to win congklak with the help of mathematical computation.
A combination of vigenere algorithm and one time pad algorithm in the three-pass protocol
Authors: Rachmawati Dian , Sharif Amer , Sianipar Rosalia
Published: September 2018

Cryptography is the method of delivery of messages in secret, thus only the intended message recipient can read the message. In this study, the cryptographic algorithms which used are Vigenere Cipher and One Time Pad. However, the security of both algorithms depends on the security of the algorithm key. Three-Pass Protocol is a scheme of work that lets two people exchange secret messages without doing a key exchange. So, both the symmetric cryptographic algorithms combined on a Three-Pass Protocol scheme. The purpose of the combination of two algorithms in the three-pass protocol is to secure the image message without exchange key process between sender and recipient. The results of the research and testing using GetPixel pointed out that safeguarding the image file using the combination of Vigenere Cipher and One Time Pad algorithm restores the original image files intact. Therefore, it meets the parameters of the integrity of the data. The test results based on time parameter shows that time of the program execution process is directly proportional to the size of the image. The result is related with the formula which calculate every pixels of the the image.
Recommendation system for selecting universities in Indonesia using Google Maps API services
Authors: Atmadja Aldy Rialdy
Published: September 2018

University is the highest education level to be achieved by many people in Indonesia. Finding information about universities is often required by Senior High School students to continue their studies. This information contains the university name, location and the quality of the majors. Distance is one of the factors that becomes the consideration for many people to pursue the higher education. Thus, the use of supporting technology to search the nearest campus will be needed by these students. The purpose of this research is to design the system that can facilitate the students in Indonesia in choosing the nearest university based on majors, accreditation, city, and province. The searching method to get the nearest location is also done by Google Maps API Service. The amount of data to be used in this research are from DIKTI that include list of universities and majors in Indonesia. The results of this study expect the college recommendation can be used as a reference for students in choosing college at college.
Laser induced ablation of aluminum nanoparticle: a molecular dynamics study
Authors: Fahdiran Riser , Handoko Erfan , Sugihartono Iwan , Urbassek Herbert M.
Published: September 2018

We investigate ablation of Aluminum nanoparticle due to ultrashort high-intensity laser pulse. Molecular dynamics simulation is used to follow the evolution of the system and observe thermodynamics together with cluster properties. The energy given from the laser to the system is 1.5 eV/atom which is above ablation threshold and modelled using instantaneous and homogenous energization at the beginning of simulation. The evolution of the system shows a highly non-equilibrium state after the irradiation. Expansion of the sphere indicated that the system cannot survive from the temporary high tensile pressure that leads to ablation. While the high temperature consecutively responsible for the formation of cluster, it also indicated that the system is relaxed at the end of the simulation.