bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Yoga and Mindfulness Intervention on Symptoms of Anxiety and Depression in Young Adolescents Attending Middle School: A Pragmatic Community-Based Cluster Randomized Controlled Trial in a Racially Diverse Urban Setting
Authors: Bazzano Alessandra N. , Sun Yaoyao , Chavez-Gray Vaughne , Akintimehin Temitope , Gustat Jeanette , Barrera Denise , Roi Cody
Published: September 2022

Mental health conditions in childhood and adolescence are increasing in the U.S. population and require early intervention, as highlighted by a recent Surgeon General’s Advisory on Protecting Youth Mental Health. These health issues, which have been exacerbated by the COVID-19 pandemic, impair functioning, and may lead to longer term reductions in quality of life. Young adolescents are likely to experience stressors including academic pressure, feelings of loneliness and isolation, and excessive exposure to social media, all of which have been made worse by the pandemic and associated disruptions. Universal preventive programs at school serve as an important strategy for equipping youth with coping skills to address current and future social and emotional challenges. Yoga and mindfulness programs have emerged as a promising preventive approach for schools and have proven feasible and acceptable. The current study evaluated a universal, school-based mindfulness and yoga program among youth aged 11–14 in a racially diverse, urban setting in the United States. Outcomes of interest included symptoms of anxiety and depression. Anxiety and depression symptoms decreased in the intervention group, although these differences were not statistically significant. In the control group, anxiety symptoms decreased but depression symptoms increased. The resulting time effect indicated a significant decrease in anxiety symptoms, while the time by group effect revealed a strong trend in depression symptoms. Future research should investigate the utility of yoga and mindfulness interventions for early adolescents in a larger population, and the differences in intervention effect among subgroups, with attention to longer term outcomes.
Assessing the Impact of Marine Tourism and Protection on Cultural Ecosystem Services Using Integrated Approach: A Case Study of Gili Matra Islands
Authors: Banarsyadhimi Urai Ridho A. M. F. , Dargusch Paul , Kurniawan Fery
Published: September 2022

Cultural ecosystem services (CES) are intangible benefits people obtain from an ecosystem through physical and cognitive interactions. Understanding CES provides vital insights into how activities impacting ecosystem services also impact people. Gili Matra Islands, a set of three small tropical islands located in West Nusa Tenggara Province, Indonesia, are an increasingly busy marine tourism destination and a marine protected area. By integrating a hedonic monetary value model with a eudaemonic non-monetary value model, this study examines the impacts of tourism and marine protected area management on cultural ecosystem services in the Gili Matra Islands. Results showed that the distance had significantly influenced property prices to coastlines, beach spots and coastlines with sunset views. In addition, the property prices of each individual island showed significant correlations with particular marine tourism and protection features. Less restricted marine protected zones and coastlines were the most significantly influencing variables to the strong eudaemonic well-being dimensions expressed by residents. The Spiritual dimension produced the highest score and was most significantly affected by several features. This study utilised higher accuracy of properties and residents’ location, enabling more accurate assessments of interaction between CES and the features. This study also discusses how these novel insights in the small island’s CES case can inform vulnerability assessments, reviews of recreation taxes, and spatial planning for marine protected areas and help optimise beach nourishments.
Assessing Changes in the Ecosystem Services Value in Response to Land-Use/Land-Cover Dynamics in Shanghai from 2000 to 2020
Authors: Gong Yuan , Cai Mengmeng , Yao Lei , Cheng Linsong , Hao Chunxu , Zhao Zheng
Published: September 2022

Land resources are foundational for human survival and development. In contrast, land use/land cover (LULC) dynamics drive considerable changes in ecosystem services. Recently, China witnessed a new stage of rapid urbanization. Therefore, investigating the relationships between ecosystem services value (ESV) and LULC in these areas is highly relevant. Based on the data of land use and socioeconomic development in Shanghai from 2000 to 2020, we adopted a land use/land cover dynamics analysis method and established the ESV per unit area at the city scale, discussed the impact of LULC on ESV spatially and quantitatively, and tested the research process based on the sensitivity analysis of the ESV coefficient. The results show that from 2000 to 2020, the LULC pattern in Shanghai rapidly changed. In particular, the area of cultivated land has shrunk by 123.96 thousand hm2, while the construction land has expanded by 141.26 thousand hm2, which has led to a decline in ESV of the entire city (especially regarding hydrological adjustment and biodiversity). Nevertheless, although the area of trench and lakes only occupies 1.67–3.16% of the total area of land, its ecological value accounts for an astonishing 23.80–50.70% of the total ESV. At the district level, the primary decline in eco-system services value was noted in the Chongming District in the north and Pudong New Area in the east of Shanghai. However, due to the overall planning of the city and the advantages of its resource endowment, Qingpu District and its surrounding areas in western Shanghai have witnessed improvements in terms of the values of hydrological adjustment, water supply, and environmental purification. This study presents a deeper and more comprehensive understanding of issues regarding ESV in rapidly urbanized areas, thereby providing an important reference for decision-makers regarding the rational layout of cities, sustainable use of land, and management of natural ecosystems.
Good Practices on Endoscope Reprocessing in Italy: Findings of a Nationwide Survey
Authors: Scarpaci Michela , Cosci Tommaso , Tuvo Benedetta , Guarini Alessandra , Iannone Teresa , Zullo Angelo , Casini Beatrice
Published: September 2022

Background: Correct reprocessing and microbiological surveillance on endoscopes are fundamental for preventing the transmission of multi-drug resistant strains and device-related infections. Methods: A questionnaire with three domains was created: (1) centre characteristics; (2) endoscope reprocessing procedures; and (3) application of microbiological surveillance. Nurses working in endoscopic units across Italy were invited to anonymously fill out the questionnaire on the SurveyMonkey platform between November 2021 and February 2022. Results: A total of 82 out of 132 endoscopic centres participated in the survey, with at least one centre from each Italian region. Data found different concerns regarding the current practice of both reprocessing and microbiological surveillance. According to respondents, the training on reprocessing was performed through theoretical training and only in 10% of centres; the microbiological surveillance was regularly performed in 59% of centres; and sampled endoscopes were not excluded for use in 31% of centres performing the surveillance until the outcome was pending, and when positive, 72% maintained them in quarantine until a successive negative result. Conclusions: Reprocessing and microbiological surveillance currently present several criticisms along the endoscopic centres in Italy. Our survey highlights the need for the correct application of the national recommendations in each endoscopic centre to prevent the potential transmission of endoscope-related infections.
Effectiveness of Pilates Training on Body Composition and Isokinetic Muscular Strength in Adolescent Baseball Players
Authors: Yook Jang Soo , Kim Da Yoon , Choi Dong Hun , Ha Min-Seong , Hwang Yoon Young
Published: September 2022

Body composition and muscular strength are important for baseball skills and successful performance. Conditioning training programs have the potential to enhance athletic performance via physiological changes. In this single-group interventional study, we investigated the effect of 8 weeks of Pilates training (PT) on contralateral and regional body composition, and isokinetic muscular strength in knee and trunk flexion/extension in adolescent baseball players. In our results, PT increased both right- and left-sided lean mass in the trunk. Following PT, work per repetition and average power showed significant increases in the flexion and extension of the left knee only. PT significantly decreased the peak torque of the trunk flexor and increased the average power of the trunk extensor. In addition, the ratio of the trunk flexion/extension strength of peak torque showed a decreasing trend, whereas that of work and average power did not change significantly following PT. In conclusion, PT evenly improved lean mass on both the right and left sides of the body. Knee and trunk strength increased after PT. Our findings suggest that PT may be a useful strategy for enhancing athletic performance in regard to the muscular strength of adolescent baseball players.
Adaptation and Validation of the Constructivist Teaching Practices Inventory in Elementary Physical Education (CTPI-EPE) for Brazilian Physical Education Pre-Service Teachers
Authors: Backes Ana F. , Ramos Valmor , Quinaud Ricardo T. , Brasil Vinicius Z. , Carvalho Humberto M. , Ibáñez Sergio J. , Nascimento Juarez V.
Published: September 2022

Constructivism is used as a powerful theoretical outlook to support teaching, learning, and curriculum in physical education and sport. The Constructivist Teaching Practices Inventory in Elementary Physical Education (CTPI-EPE) is a valid instrument for assessing in-service teachers. However, there is a need to translate constructivist teaching practices for PE into other languages. This study examined the validity of the Portuguese version of the adapted CTPI-EPE for Brazilian physical education preservice teachers (PST). The sample comprised of 869 physical education PSTs from Brazil. Data were collected through an online form. Aiken’s V was used to examine content validity, and Bayesian methods used for exploratory and confirmatory factor analysis. The results showed adequate content and internal structure of the translated and adapted questionnaire. This study highlighted the validity of the Portuguese version of the CTPI-EPE, which could be considered an important instrument for self-reflection by PSTs, and provide information for improved training in higher education toward constructivist teaching.
Lycium barbarum Polysaccharide Regulates the Lipid Metabolism and Alters Gut Microbiota in High-Fat Diet Induced Obese Mice
Authors: Xia Hui , Zhou Beijia , Sui Jing , Ma Wenqing , Wang Shaokang , Yang Ligang , Sun Guiju
Published: September 2022

Bioactive compounds provide new insights into the prevention and treatment of obesity. Lycium barbarum polysaccharide (LBP), a biological macromolecule extracted from Goji berry, has displayed potential for regulating lipid metabolism. However, the relationship between gut microbiota regulation and lipid metabolism is not entirely clear. In the present study, 50, 100, and 150 mg/kg LBP were intragastrically administered to C57BL/6J male mice fed with a high-fat diet simultaneously lasting for twelve weeks. The results showed that 150 mg/kg LBP showed significant results and all doses of LBP feeding (50, 100, 150 mg/kg) remarkably decreased both serum and liver total cholesterol (TC) and triglyceride (TG) levels. Treatment of 150 mg/kg LBP seems to be more effective in weight loss, lowering free fatty acid (FFA) levels in serum and liver tissues of mice. LBP feeding increased the gene expression of adiponectin and decreased the gene expression of peroxisome proliferator-activated receptor γ, Cluster of Differentiation 36, acetyl-coA carboxylase, and fatty acid synthase in a dose-dependent manner. In addition, the 16s rDNA Sequencing analysis showed that 150 mg/kg LBP feeding may significantly increase the richness of gut microbiota by up-regulation of the ACE and Chao1 index and altered β-diversity among groups. Treatment of 150 mg/kg LBP feeding significantly regulated the microbial distribution by decreasing the relative abundance of Firmicutes and increasing the relative abundance of Bacteroidetes at the phylum level. Furthermore, the relative abundance of Faecalibaculum, Pantoea, and uncultured_bacterium_f_Muribaculaceae at the genus level was significantly affected by LBP feeding. A significant correlation was observed between body weight, TC, TG, FFA and bile acid and phyla at the genus level. The above results indicate that LBP plays a vital role in preventing obesity by co-regulating lipid metabolism and gut microbiota, but its effects vary with the dose.
Transmission and Control of SARS-CoV-2 in the Food Production Sector: A Rapid Narrative Review of the Literature
Authors: Hosseini Paniz , Mueller William , Rhodes Sarah , Pembrey Lucy , van Tongeren Martie , Pearce Neil , Loh Miranda , Fletcher Tony
Published: September 2022

This review aimed to provide an overview of the literature assessing the extent of COVID-19 transmission in the food processing sector along with the risk factors associated with COVID-19 infection/mortality rates in this setting, and the preventive measures used to reduce transmission. An electronic search was conducted using scientific databases, including Web of Science, OVID, PubMed and MedRxiv. The search strategy identified 26 papers that met the inclusion criteria. Six of these studies were based in the UK and the country with the most papers was the USA, with a total of nine papers. Findings showed some evidence of a high transmission level of SARS-CoV-2 within some areas of the food production sector. Risk factors associated with the spread included ethnicity, poor ventilation, lack of social distancing and lack of sick pay. The preventative measures included/recommended were social distancing, testing, adequate ventilation, cleaning regimes and access to PPE. Additional research focusing on the food production sector could show the potential variations in transmission and risk between each sub-sector. Future research focusing on the application of various preventative measures and their efficacy by sub-sector would be beneficial, while further qualitative research could help provide in-depth information regarding knowledge gaps.
Review of Fibromyalgia (FM) Syndrome Treatments
Authors: Cohen-Biton Liraz , Buskila Dan , Nissanholtz-Gannot Rachel
Published: September 2022

Background: Fibromyalgia (FM) is a disease characterized by widespread musculoskeletal chronic pain that impairs the patient’s quality of life and is considered a somatization disorder. The symptoms of the disease also affect the patient mentally, mainly since invisible pain is the only thing that indicates its existence. A typical symptom that characterizes FM patients is the lack of acceptance of the disease since its pathophysiology is not elucidated, hence the deficiencies in its management, or rather, cognitively, the belief that there is no disease to manage. The current paper aims to shed light on the new treatment methods at a holistic level, that is, cognitive, physical, and pharmacological therapies. Method: A literature review was carried out that discusses treatment methods that help alleviate the pain, accept it, and manage the symptoms of the disease. Results: FM symptoms can be treated by taking a broad view of treatment that will include a response to the mind through pain management, response to the body through physical activity, and response to the pain through pharmacological treatment. Conclusions: Today, there is an evolutionary view that accepts FM and chronic pain diseases as syndromes in which the pain is the disease; therefore, the response to this disease can be applied through three channels: physical, bodily, and mental.
Gestational and Neonatal Outcomes in Cities in the Largest Coal Mining Region in Brazil
Authors: Soares Renata Dupont , dos Santos Marina , de Moura Fernando Rafael , Muccillo-Baisch Ana Luiza , Baisch Paulo Roberto Martins , Soares Maria Cristina Flores , da Silva Júnior Flavio Manoel Rodrigues
Published: September 2022

Brazil has one of the largest mineral coal reserves in the world. More than 40% of this ore is in the Candiota Mine, in the extreme south of Brazil, which was previously identified as a hotspot of environmental pollution. In addition, an important part of Brazil’s population suffers from socioeconomic vulnerability. Since there is no information on unfavorable gestational and neonatal outcomes associated with these problems, we conducted a cross-sectional study with 1950 mother–child binomials, aiming to evaluate the association between these outcomes and air pollution as well as socioeconomic, demographic and health variables in seven cities in the region. Of the total births, 11.6% were preterm and 9.5% of neonates had low birth weight (<2500 g). These conditions were also associated with skin color, previous abortions, birth type and prenatal care, as well as exposure to higher levels of coarse particulate matter (PM10) during the first trimester of pregnancy. Regarding air pollutants, although the daily limits for PM10 were exceeded on less than 5% of days, the annual average overtook the values proposed by WHO. Thus, we concluded that prematurity and low birth weight in this region are related to air pollution, and to socioeconomic variables and health care.
Injuries to Users of Single-Track Vehicles
Authors: Leszczyński Piotr Konrad , Kalinowska Justyna , Mitura Krzysztof , Sholokhova Daryna
Published: September 2022

Introduction: Single-track vehicles (including, among others, scooters, bicycles, mopeds, and motorcycles) are becoming increasingly popular means of transport, especially in large cities. A significant disadvantage of single-track vehicles is the low level of protection of users’ bodies during road accidents, which causes life-threatening injuries. The aim of this study is to characterize the injuries of users of single-track vehicles. Material and methods: An analysis of medical documentation of the ambulance service in the region of central Poland covered cases in 2019–2020. Out of 17,446 interventions, a group of 248 road incidents involving single-track vehicles was selected. The data included the scene of the event, the sociodemographic data of the casualties, the injuries suffered, and the clinical diagnoses. Analyses of the correlation of variables with the chi-squared and Spearman’s Rho tests were applied. All results were considered significant at p < 0.05. Results: In the analyzed period, trips of men accounted for 83.5% of all of the interventions (n = 207), while trips of women accounted for 16.5% (n = 41). The mean age of the victims was 45.66 years (SD ± 20.45). Taking into account the division of single-track vehicles, individual cases were recorded with the participation of bicycles (n = 183), motorcycles (n = 61), and scooters (n = 4). Taking into account the type of event, the following were distinguished: deductions (n = 62), falls (n = 179), and sickness (n = 7). The most common injuries were to the heads of cyclists (n = 101, which constitutes 55.19% of all injuries), lower limb injuries in motorcyclists (n = 35; 57.38%), and head injuries in scooter users (n = 3; 75%). The locations of sustained injuries significantly correlated with the type of vehicle in the cases of head injuries (p = 0.046), spine/back injuries (p = 0.001), pelvis injuries (p = 0.021), and lower limb injuries (p = 0.001). Conclusions: The users of single-track vehicles injured in road accidents were more often men than women. The characteristics of the injuries depended on the type of vehicle. The lack of adequate body protection significantly increases the likelihood of death or damage to health. It is advisable to promote safety rules among users of single-track vehicles, with a particular emphasis on the protection of individual parts of the body.
The Association between Early Opioids Prescribing and the Length of Disability in Acute Lower Back Pain: A Systematic Review and Narrative Synthesis
Authors: Ibrahim Ayman R. , Elgamal Mohamed E. , Moursi Moaz O. , Shraim Bara A. , Shraim Muath A. , Shraim Mujahed , Al-Omari Basem
Published: September 2022

Background: There is conflicting evidence with respect to whether early opioid prescribing (EOP) within the first two weeks of acute Low Back Pain (LBP) onset is associated with the length of disability (LOD). The aim of this systematic review was to examine the relationship between EOP and LOD in individuals with acute LBP. Methods: A systematic search of Medline, EMBASE, and CINAHL was conducted. The Newcastle–Ottawa scale was used to assess the methodological quality of included studies. A narrative synthesis of findings was used owing to between-study heterogeneity. Results: Six cohort studies using workers’ compensation administrative data on 178,130 adults with LBP were included. Most studies were of good methodological quality. One study reported that LBP cases with EOP had higher LOD by 4 days than cases without EOP. Two studies reported that each 100 mg morphine equivalent amount (MEA) was associated with an increase in mean LOD by 0.4 day (95% confidence interval (CI): 0.3, 0.5) and 0.4 day (95% CI: 0.3, 0.4). One study showed that LBP cases with EOP had a higher hazard of continuation of time loss benefits by 1.94 (95% CI 1.86, 2.02). One study reported a dose–response relationship between MEA of EOP and LOD ranging between 5.2 days (95% CI 14.6, 25.0) for 1–140 mg MEA and 69.1 (95% CI 49.3, 89.0) for 450+ mg MEA. One study reported that LBP cases with EOP had a higher mean LOD by 3.8 days, but there was no statistically significant relationship between EOP and LOD (Hazard ratio 1.02; 95% CI 0.91, 1.13). Conclusions: The use of early opioid in the management of acute uncomplicated LBP is associated with prolonged disability duration. Further research on factors influencing inadequate adherence to evidence-based guidelines and optimal strategies to modify such factors may improve disability outcomes among patients presenting with acute LBP.
Analysing the Quality of Life of Older Adults: Heterogeneity, COVID-19 Lockdown, and Residential Stability
Authors: Chen Ching-Yi
Published: September 2022

This study aims to, first, investigate the quality of life (QOL) of older adults in Taiwan, from the perspective of heterogeneity and, second, clarify the social isolation affecting their QOL during the pandemic. Additionally, it explores the residential stability of older adults. Our empirical model, a Generalized Ordered Probit Model, uses secondary data from the 2019 Taiwan Social Change Survey for people aged 65 and above, with a total sampling size of 417. The results show that the self-assessed physical health of older adults is a significantly heterogeneous variable affecting their QOL, and has a varying impact on the probability of them being satisfied with their QOL. Results suggest that better financial plans and staying healthy are the main determinants of their QOL. Social isolation during the COVID-19 pandemic significantly hampered their QOL, which was not compensated by the use of the internet. Furthermore, older adults’ residential stability significantly influences their QOL. Family members and relevant social work units should contribute to in-person home care for older adults to reduce their social isolation, with a focus on improving their living environments and to ensure that they age in a safe and healthy place.
Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study
Authors: Compañ-Gabucio Laura María , Torres-Collado Laura , Garcia-de la Hera Manuela , Fernández-Somoano Ana , Tardón Adonina , Julvez Jordi , Sunyer Jordi , Rebagliato Marisa , Murcia Mario , Ibarluzea Jesús , Santa-Marina Loreto , Vioque Jesús
Published: September 2022

This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7–9. A longitudinal analysis based on 1609 mother–child pairs from the Spanish Infancia y Medio Ambiente Project was carried out. Multivariable regression analyses revealed that, compared to the recommended FAs use, a low FAs use during the second period of pregnancy was associated with a lower alertness in all children (β = 18.70 ms; 95% CI: 7.51; 29.89) and in girls (β = 30.01 ms; 95% CI: 12.96; 47.01), and with a lower N-back Task performance in boys (d’ number 2-back (β = −0.25; 95% CI: −0.49; 0.01)). A high FAs use throughout the two periods of pregnancy was associated with a better N-back Task performance only in girls (d’ number 2-back (β = 0.28; 95% CI: 0.01; 0.56) and d’ number 3-back (β = 0.32; 95% CI: 0.08; 0.56)). The maternal use of FAs beyond the periconceptional period may affect children’s attentional function and working memory at age 7–9 differently for boys and girls.
Effects of Straw Return and Moisture Condition on Temporal Changes of DOM Composition and Cd Speciation in Polluted Farmland Soil
Authors: Yang Guang , Tang Xiangyu , Guan Zhuo , Cui Junfang
Published: September 2022

Straw return can improve soil quality and change the mobility and bioavailability of pollutants in soil. Elevated cadmium (Cd) contents in farmland soils were often reported. However, the impacts of straw-derived dissolved organic matter (DOM) on Cd speciation in soil remain poorly understood. In this study, the effects of straw return and moisture condition on temporal changes of DOM composition and Cd speciation in farmland soils were explored through a laboratory incubation experiment. The humified components of DOM were negatively correlated with exchangeable, carbonate-bound, and Fe-Mn oxide-bound Cd (p < 0.01), while its protein-like component was negatively correlated with residual Cd (p < 0.01). It was found that selected fluorescence parameters could be used to predict temporal changes of Cd geochemical fractions. Straw addition led to increases in soil DOM content during the first three days of the incubation. Flooding should be avoided in the first three days following the straw application to reduce the risk of DOM-facilitated Cd mobilization.
Acceptance of COVID-19 Vaccine Booster Doses Using the Health Belief Model: A Cross-Sectional Study in Low-Middle- and High-Income Countries of the East Mediterranean Region
Authors: Ghazy Ramy Mohamed , Abdou Marwa Shawky , Awaidy Salah , Sallam Malik , Elbarazi Iffat , Youssef Naglaa , Fiidow Osman Abubakar , Mehdad Slimane , Hussein Mohamed Fakhry , Adam Mohammed Fathelrahman , Abdullah Fatimah Saed Alabd , Rebai Wafa Kammoun , Raad Etwal Bou , Hussein Mai , Shehata Shehata F. , Ismail Ismail Ibrahim , Salam Arslan Ahmed , Samhouri Dalia
Published: September 2022

Coronavirus disease (COVID-19) booster doses decrease infection transmission and disease severity. This study aimed to assess the acceptance of COVID-19 vaccine booster doses in low, middle, and high-income countries of the East Mediterranean Region (EMR) and its determinants using the health belief model (HBM). In addition, we aimed to identify the causes of booster dose rejection and the main source of information about vaccination. Using the snowball and convince sampling technique, a bilingual, self-administered, anonymous questionnaire was used to collect the data from 14 EMR countries through different social media platforms. Logistic regression analysis was used to estimate the key determinants that predict vaccination acceptance among respondents. Overall, 2327 participants responded to the questionnaire. In total, 1468 received compulsory doses of vaccination. Of them, 739 (50.3%) received booster doses and 387 (26.4%) were willing to get the COVID-19 vaccine booster doses. Vaccine booster dose acceptance rates in low, middle, and high-income countries were 73.4%, 67.9%, and 83.0%, respectively (p < 0.001). Participants who reported reliance on information about the COVID-19 vaccination from the Ministry of Health websites were more willing to accept booster doses (79.3% vs. 66.6%, p < 0.001). The leading causes behind booster dose rejection were the beliefs that booster doses have no benefit (48.35%) and have severe side effects (25.6%). Determinants of booster dose acceptance were age (odds ratio (OR) = 1.02, 95% confidence interval (CI): 1.01–1.03, p = 0.002), information provided by the Ministry of Health (OR = 3.40, 95% CI: 1.79–6.49, p = 0.015), perceived susceptibility to COVID-19 infection (OR = 1.88, 95% CI: 1.21–2.93, p = 0.005), perceived severity of COVID-19 (OR = 2.08, 95% CI: 137–3.16, p = 0.001), and perceived risk of side effects (OR = 0.25, 95% CI: 0.19–0.34, p < 0.001). Booster dose acceptance in EMR is relatively high. Interventions based on HBM may provide useful directions for policymakers to enhance the population’s acceptance of booster vaccination.
Assessing the Testability of the Multi-Theory Model (MTM) in Predicting Vaping Quitting Behavior among Young Adults in the United States: A Cross-Sectional Survey
Authors: Sharma Manoj , Batra Kavita , Batra Ravi , Dai Chia-Liang , Hayes Traci , Ickes Melinda J. , Singh Tejinder Pal
Published: September 2022

Purpose: Given the increased exposure to e-cigarettes and nicotine among young adults, difficulty in quitting vaping is likely, which supports the need for effective behavioral interventions. Therefore, this cross-sectional study aims to assess the testability of the contemporary multi-theory model of health behavior change in predicting the vaping quitting behavior among young adults in the United States. Methods: A nationally representative sample of 619 young adults engaged in vaping behavior and aged 18–24 years was recruited to complete a 49-item web-based survey. A structural equation model was used to test relationships between MTM constructs. Hierarchical multiple regression was utilized to predict the variance in the initiation and sustenance of vaping quitting behavior by predictor variables, such as demographic characteristics, history of behaviors, and MTM constructs. Results: Of 619 respondents, over 75% were White and nearly 70% had educational attainment equal to high school or some college. In total, 62% of respondents were using nicotine, followed by 33.3% were using cannabis. About 80% of the respondents reported being engaged in drinking alcohol, and nearly 45% were engaged in cigarette smoking. The predictive effect of all MTM constructs on vaping quitting initiation (adjusted R2 = 0.417, F (23, 595) = 20.215, p < 0.001) and sustenance (adjusted R2 = 0.366, F (23, 595) = 16.533, p < 0.001) was statistically significant. Conclusions: The findings of this study point to the usability and applicability of MTM in operationalizing and developing vaping quitting behavior interventions targeting young adults.
People’s Perception of Well-Being during the COVID-19 Pandemic: A Case Study in Japan
Authors: Sasaki Daisuke , Suppasri Anawat , Tsukuda Haruka , Nguyen David N. , Onoda Yasuaki , Imamura Fumihiko
Published: September 2022

This study aims to examine people’s perception of well-being during the COVID-19 pandemic in Japan and quantitatively clarify key factors towards realizing evidence-based policymaking. In March 2022, 400 participants responded to a survey conducted through Rakuten Insight. The authors applied an ordinal logistic regression (OLR), followed by principal component analysis (PCA), to create a new compound indicator (CI) to represent people’s perception of well-being during the pandemic in addition to ordinary least squares (OLS) regression with a forward-backward stepwise selection method, where the dependent variable is the principal component score of the first principal component (PC1), while the independent variables are the same as the abovementioned OLR. Consequently, while analyzing OLR, some independent variables showed statistical significance, while the CI provided an option to grasp people’s perception of well-being. Furthermore, family structure was statistically significant in all cases of OLR and OLS. Moreover, in terms of the standardized coefficients (beta) of OLS, the family structure had the greatest impact on the CI. Based on the study results, the authors advocate that the Japanese government should pay more attention to single-person households affected by the COVID-19 pandemic.
Diagnostic Performance Evaluation of the Novel Index Combining Urinary Cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in Smoking Status Verification and Usefulness for Trend Monitoring of Tobacco Smoking Exposure
Authors: Lee Hyun-Seung
Published: September 2022

During the last decade in Korea, urinary cotinine concentrations in non-current smokers have decreased, making it difficult to distinguish secondhand smoke (SHS) exposure from nonsmokers because of overlapping values between non-current smokers with and without SHS exposure. Additionally, the importance of smoking status verification to avoid misclassification is increasing with the increased use of e-cigarettes. We developed a novel index combining urinary cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and evaluated its diagnostic performance for the classification of smoking status using the KNHANES VII dataset. A total of 10,116 and 5575 Korean participants aged >19 years with measured urinary cotinine concentrations were enrolled in a training set and validation set, respectively. When using 4.0 as the cutoff value for distinguishing current smokers from non-current smokers, urinary cotinine∙NNAL showed a better diagnostic performance than urinary cotinine or urinary NNAL. Among e-cigarette users, urinary cotinine∙NNAL showed more accurate classification rates than urinary NNAL. Furthermore, urinary cotinine∙NNAL had measurable values in non-current smokers, whereas urinary cotinine had unmeasurable values in one-fourth of all participants. This study shows that urinary cotinine∙NNAL might be a useful biomarker for smoking status verification and trend monitoring of tobacco smoking exposure with increased use of e-cigarettes.
How Stress Is Related to Age, Education, Physical Activity, Body Mass Index, and Body Fat Percentage in Adult Polish Men?
Authors: Lopuszanska-Dawid Monika , Kupis Przemysław , Lipowicz Anna , Kołodziej Halina , Szklarska Alicja
Published: September 2022

Stressful events and chronic tension are considered a burden and a threat to physical, mental, and social health. The aim of the study was to demonstrate the associations of variation in stress exposure with social factors, physical activity, basic components of physical fitness, body mass index (BMI) and percentage of body fat (BFP). An additional objective was to identify the main BFP modifiers among those analyzed. The material consisted of data of ethnically homogeneous group 355 men (32–87 yrs), invited to the study as part of the Wroclaw Male Study research project. The analyzed features included socioeconomic status (age, educational level), elements of lifestyle (physical activity), major and most important stressful life events—Social Readjustment Rating Scale (SRRS) and basic parameters of the somatic structure of the body (BMI, BFP). Statistical analyses included: chi-square test, Mann–Whitney U test and backward stepwise regression (significance level α = 0.05). Stress exposure showed significant socioeconomic variation among the adult Poles studied. Higher levels of education were associated with higher levels of stress. Significant correlations between SRRS and physical activity were found, especially in men older than 60 years and with higher levels of education. A positive relationship was shown between SRRS and BFP, especially in men under 60 years of age. BFP appeared to depend mainly on age and stress. The main determinants of SRRS were age and education level, while BFP turned out to be more sensitive to stress than BMI. The modifying force of physical activity for SRRS appears to be age dependent.
Systematic Review of Survival Analysis in Leprosy Studies—Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability
Authors: Barbosa Celivane Cavalcanti , Bezerra Gilberto Silva Nunes , Xavier Amanda Tavares , Albuquerque Maria de Fátima Pessoa Militão de , Bonfim Cristine Vieira do , Medeiros Zulma Maria de , Souza Wayner Vieira de
Published: September 2022

Leprosy is a public health problem in South American, African and Oceanian countries. National programs need to be evaluated, and the survival analysis model can aid in the construction of new indicators. The aim of this study was to assess the period of time until the outcomes of interest for patients with or exposed to leprosy by means of survival analysis surveys. This review researched articles using the databases of PubMed, Science Direct, Scopus, Scielo and BVS published in English and Portuguese. Twenty-eight articles from Brazil, India, Bangladesh, the Philippines and Indonesia were included. The Kaplan–Meier method, which derives the log-rank test, and Cox’s proportional hazards regression, which obtains the hazard ratio, were applied. The mean follow-up until the following outcomes were: (I) leprosy (2.3 years) in the population who were exposed to it, (II) relapse (5.9 years), (III) clinical manifestations before, during and after treatment—nerve function impairment (5.2 years), leprosy reactions (4.9 years) and physical disability (8.3 years) in the population of patients with leprosy. Therefore, the use of survival analysis will enable the evaluation of national leprosy programs and assist in the decision-making process to face public health problems.
The Needs, Use and Expectations of People Bereaved by Suicide Regarding Online Resources: An Online Survey
Authors: Leaune Edouard , Rouzé Héloïse , Lestienne Laurène , Bislimi Kushtrim , Chalancon Benoit , Morgiève Margot , Grandgenèvre Pierre , Vaiva Guillaume , Laplace Nathalie , Poulet Emmanuel , Haesebaert Julie
Published: September 2022

Background: Online resources constitute a new and effective way to obtain support or information during bereavement processes. However, little is known about the needs, use and expectations of people bereaved by suicide regarding online resources. Method: The objective of our national cross-sectional online survey was to collect the use, needs and expectations of people bereaved by suicide regarding online resources. The data were collected from July to October 2021 through a 26-item online questionnaire hosted on the website LimeSurvey. Results: A total of 401 respondents fully completed the questionnaire. Their mean age was 45.7. The majority of participants were women bereaved by the suicide of their child or partner. Half of the participants were bereaved for less than 3 years and benefited from counselling during their bereavement process. Three-quarters of the participants used the Internet for their bereavement process, mainly to obtain information on suicide bereavement and suicide prevention and to access testimonies of other people bereaved by suicide. Three-quarters of the participants found that available online resources for people bereaved by suicide are insufficient and expected a dedicated web platform to be developed. Finding information on suicide bereavement and on suicide prevention, discussing with a mental health professional and accessing testimonies of other people bereaved by suicide were expected by a majority of the participants regarding the future platform. Receiving counselling and being bereaved by the death of a child were the most important factors in explaining patterns of use and expectations regarding online resources. Discussion: Our results offer precise insights into the needs, use and expectations of people bereaved by suicide regarding online resources. The development of web platforms offering access to reliable information on suicide bereavement and on suicide prevention to peers bereaved by suicide and help to seek counselling are urgently needed.
Internet Use and Job Satisfaction: Evidence from China
Authors: Zhou Dan , Yang Sibo , Li Xue
Published: September 2022

We explore the causal effects of Internet use on job satisfaction using a sample of 83,012 Chinese labor force members aged 16–64 years from the China Family Panel Studies (CFPS) from 2010 to 2018. We use ordered logistic estimation and find that Internet use significantly increases job satisfaction by 3.2%. Heterogeneity analysis shows that the Internet has a more positive impact on those who are in urban areas and have higher incomes and higher education. Our results are robust after eliminating endogeneity using instrumental variables and solving the self-selection problem using the PSM method. Our mechanistic analysis leads to similar conclusions to mainstream research, where Internet use induces job satisfaction by increasing time efficiency and enhancing job autonomy. Specifically, shorter working hours boosted job satisfaction by approximately 0.3%, while working in informal places boosted job satisfaction by 5.4%. Thus, employers may consider encouraging employees to access the Internet.
A GloVe Model for Urban Functional Area Identification Considering Nonlinear Spatial Relationships between Points of Interest
Authors: Chen Yue , Qian Haizhong , Wang Xiao , Wang Di , Han Lijian
Published: September 2022

As cities continue to grow, the functions of urban areas change and problems arise from previously constructed urban planning schemes. Hence, the actual distribution of urban functional areas needs to be confirmed. POI data, as a representation of urban facilities, can be used to mine the spatial correlation within the city. Therefore it has been widely used for urban functional area extraction. Previous studies are mostly devoted to mining POI linear location relationships and do not comprehensively mine POI spatial information, such as spatial interaction information. This results in less accurate modeling of the relationship between POI-based and urban function types. In addition, they all use Euclidean distance for proximity assessment, which is not realistic. This paper proposes an urban functional area identification method that considers the nonlinear spatial relationship between POIs. First, POI adjacency is determined according to road network constraints, which forms the basis of a co-occurrence matrix. Then, a Global Vectors (GloVe) model is used to train POI category vectors and the feature vectors for each basic research unit are obtained using weighted averages. This is followed by clustering analysis, which is realized by a K-Means++ algorithm. Lastly, the functional areas are labeled according to the POI category ratio, enrichment factors, and mobile phone signal heat data. The model was tested experimentally, using core areas of Zhengzhou City in China as an example. When the results were compared with a Baidu map, we confirmed that making full use of nonlinear spatial relationships between POIs delivers high levels of identification accuracy for urban functional areas.
Assessment of Efficacy and Safety Using PPAR-γ Agonist-Loaded Nanocarriers for Inflammatory Eye Diseases
Authors: Miralles Esther , Kamma-Lorger Christina S. , Domènech Òscar , Sosa Lilian , Casals Isidre , Calpena Ana Cristina , Silva-Abreu Marcelle
Published: September 2022

Drug-loaded nanocarriers (NCs) are new systems that can greatly improve the delivery and targeting of drugs to specific tissues and organs. In our work, a PPAR-γ agonist loaded into polymeric NCs was prepared, stabilized by spray-drying, and tested in vitro, ex vivo, and in vivo (animal models) to provide a safe formulation for optical anti-inflammatory treatments. The NCs were shown to be well tolerated, and no signs of irritancy or alterations of the eye properties were detected by the in vitro HET-CAM test and in vivo Draize test. Furthermore, no signs of cytotoxicity were found in the NC formulations on retinoblastoma cells (Y-79) analyzed using the alamarBlue assay, and the transmittance experiments evidenced good corneal transparency with the formulations tested. The ocular anti-inflammatory study confirmed the significant prevention efficacy using the NCs, and these systems did not affect the corneal tissue structure. Moreover, the animal corneal structure treated with the NCs was analyzed using X-ray diffraction using synchrotron light. Small-angle X-ray scattering (SAXS) analysis did not show a significant difference in corneal collagen interfibrillar spacing after the treatment with freshly prepared NCs or NCs after the drying process compared to the corresponding negative control when inflammation was induced. Considering these results, the PPAR-γ agonist NCs could be a safe and effective alternative for the treatment of inflammatory ocular processes.
Transcriptome Analysis Reveals the Complex Regulatory Pathway of Background Color in Juvenile Plectropomus leopardus Skin Color Variation
Authors: Song Feibiao , Wang Lei , Yang Zihang , Shi Liping , Zheng Da , Zhang Kaixi , Sun Junlong , Luo Jian
Published: September 2022

Fish skin color is often strongly affected by background color. We hypothesized that the regulatory mechanism of variations in skin color in P. leopardus is linked to the background color. In this study, we conducted transcriptome analysis of Plectropomus leopardus cultured under different background colors to compare gene expression levels and the important signaling pathways. The RNA-seq analysis yielded 26,675 known mRNAs, 3278 novel mRNAs, and 3179 differentially expressed genes (DEGs). The DEGs related to melanin synthesis were screened out. Some key melanin-related genes were identified, specifically tyr, slc7a11, mc1r, ednrb, dct, tat, and wnt1. These DEGs were mainly involved in melanogenesis, including tyrosine metabolism, the Wnt signaling pathway, and the cAMP signaling pathway. The expression levels of some key genes were upregulated when background color deepened, such as α-msh, wnt, and gf. The α-MSH/cAMP-dependent, Wnt/β-catenin, and PI3K/Akt signaling pathways were activated, resulting in the accumulation of intracellular mitf. mitf promoted melanin production by binding to the tyr/tyrp1/dct promoter region. In the present study, we explored the molecular mechanism underlying the darkened skin color pattern of P. leopardus, providing a theoretical basis for the molecular mechanism underlying pigmentation in P. leopardus.