bluuebunny/crossref_metadata_2025 huggingface dataset:
A Methodology for Assessing Airport Terminal Capacity Based on Service Resource Equilibrium
Authors: Zhang Liming , Yang Ze , Mou Qifeng
Published: June 2023

To effectively estimate airport terminal area capacity and assess the maximum throughput the sector can achieve when the capacity is given, this research proposes an approach to assess the terminal area capacity from the viewpoint of service provision resources. Terminal area capacity is optimized based on the equilibrium of air traffic service resource supply and demand. The supply-demand nexus is examined in consideration of terminal area route structure, traffic flow characteristics, and safety regulations. A flight service probability matrix and a terminal area demand and supply service time model are constructed to quantify resource expenditure at varied capacity levels. A optimization model is then developed to apportion maximal capacity under resource limitations. Model computation and computation results demonstrate the deviation between estimated and amended capacities is under 0.3 flight sorties per hour. The outcomes are congruent with historical statistics, thereby validating the accuracy and reliability of the model proposed in this study. Given capacity parameters, the model can deduce the maximal aircraft quantity served concurrently in terminal areas during peak periods. These revelations indicate the submitted model furnishes theoretical foundation and reference for terminal area sector partition and traffic alerting.
HUMANIZATION OF EUROPEAN RESIDENTIAL HIGH-RISE BUILDINGS BY DESIGNING COMMON ZONES
Authors:   Faculty of Architecture Wroclaw University of Science and Technology, Poland, Zamojski Tomasz
Published: June 2023

In the paper we have conducted a comparative analysis of contemporary high-rise residential buildings, taking into account the consequences of the clustering of numerous communities in buildings with a vertical functional and spatial structure. The analysis of specific solutions was aimed at the emergence of cultural, social and technological peculiarities in residential high-rise buildings in Europe in the years 2000 – 2022. The accumulated factual material made it possible to identify the distinctive features of high-rise residential buildings and to analyze them in terms of the requirements for vertical habitats, with emphasis placed on the arrangement of common zones. An analysis of the humanization of their residential environment was carried out.
Postmodern Aesthetics in African Literature
Authors: Damlègue Lare
Published: June 2023

This article examines contemporary critical positions in African literature that mark off perceptible shifts in focus from issues of primal postcolonialism to a more self-reflexive treatment of postmodernism in contemporary African literature. Contemporary African literary works, novels, and plays have become markedly self-reflexive in the way they rewrite one another and draw attention to their own functionality and fictionality. These works present stylistic and thematic departures that challenge the nationalist and realist trend of earlier writing. Creative works further depart from the tradition of “writing back” to the European colonial center by focusing their gaze on local forms of oppression that are seen to parallel classical colonialism. Yet, while critics have separately studied postmodernism and self-reflexivity in African texts, the intersection of the two has not been given sufficient attention. The purpose of this analytical paper then is to decipher postmodernist aesthetics in African literary works, novels and plays, as developed to a higher level of self-consciousness. The specific question I address is to what extent postmodernism expresses itself as an outgrowth of modernism and postcolonialism?

Keywords: Modernity, postmodernism, postcolonialism, African literary theories and criticisms.
Towards A Bully-Free Pesantren: The Role of Educational Management With Adaptive Psychology and Mental Health Interventions
Authors: Prasetyo Muhammad Anggung Manumanoso , Fadlin Iswan , Madman Ruchdee
Published: June 2023

Bullying's complexity is influenced not only by the individual's features and behavioural tendencies but also by the practice of family upbringing, as well as environmental elements such as the frequency and type of bullying. A qualitative paradigm is used in the research. The sampling method employing the purposive sampling technique seeks to identify teenagers who have been bullied. Interviews, observations, and documentation reviews of bullying episodes were used to collect data. Dayah leaders in the area of parenting serve as study informants. The veracity of the data is checked using sources of persons involved in bullying. Data triangulation techniques and peer discussion were used to examining the data. The findings revealed that verbal bullying occurred in Islamic boarding schools. Adaptive psychology is demonstrated through students' communication abilities, which are classified as passive communication, aggressive communication, and forceful communication. Meanwhile, adaptive techniques such as enhancing teacher counselling abilities (informative-communicative), monitoring assessments, and anti-bullying policies are used to provide mental health coaching. Students, on the other hand, are expected to cooperate with the facts of the occurrence under the structure of the solution-focused counselling strategy. Cultural reference, resources, research literature, formalization, and pesantren policy are all institutionally focused on in adaptive psychology. So far, the pesantren are concerned about their reputation; consequently, the societal consequences of this study need pesantren management to be upfront whenever bullying occurs.
The Concept of Spiritual-Based Character Education At Nusantara Beriman Islamic Boarding School Poleang Kendari, Southeast Sulawesi
Authors: Firmansyah Defi , Karumiadri Muh. , Maksum Muh. Nur Rochim
Published: June 2023

Responding to the moral problems that are rife in Indonesia, the concept of character education is a solution in dealing with these problems. This is related to the increase in juvenile delinquency among Muslims who are increasingly living their lives away from the application of Islamic values. Related to it, Nusantara Beriman Islamic Boarding School is one of the Islamic boarding school educational institutions that focuses on educate the morals of his students by trying to optimize spiritual-based character education that is instilled through activities at Islamic boarding schools. In this research, the author will examine the concept of character education which focuses on spiritual activities at Nusantara Islamic Boarding School Poleang. The method used by researchers is a descriptive qualitative method by making the Nusantara Beriman Islamic Boarding School as the object of research. The results of this research are, the life student dynamics at Nusantara Beriman Islamic Boarding School which emphasizes to educate student character through spiritual activities like reciting the Qur'an on the sidelines of formal education, qiyamu al-layl activities every night and traveling preaching or safari da’wah, aiming to educate the students character who have noble morals by making worship (ubudiyah) as the basic for building character. With this concept, students will also get used to pay attention to ubudiyah aspects in the process of studying and not putting it aside, so that a human character is formed that is not only intelligent in science but will continue to prioritize morals in socializing).
The Urgency of Islamic Character Education to Anticipate Bullying Behavior in Boarding Schools
Authors: Ramli Akhmad , Dhahri Irsyad , Solehuddin Moh , Rahmah St , Haris Muhammad , Lubis Fatimah Malini
Published: June 2023

Pendidikan karakter Islam memainkan peran penting dalam mengurangi perilaku bullying di sekolah berasrama, dengan membentuk perilaku siswa yang santun, toleran, dan menghargai perbedaan. Penelitian ini bertujuan untuk menganalisis urgensi pendidikan karakter Islam dalam mengantisipasi perilaku bullying di sekolah berasrama melalui metode studi literatur. Penelitian ini menggunakan pendekatan kualitatif dengan teknik analisis studi literatur. Sumber data diperoleh dari berbagai referensi seperti buku, artikel jurnal, dan hasil penelitian terkait dengan pendidikan karakter Islam dan bullying di sekolah. Data yang diperoleh dianalisis dengan menggunakan teknik analisis isi. Hasil penelitian menunjukkan bahwa pendidikan karakter Islam memiliki urgensi yang tinggi dalam mengantisipasi perilaku bullying di sekolah berasrama. Pendidikan karakter Islam dapat membentuk perilaku siswa yang santun, toleran, dan menghargai perbedaan. Selain itu, pendidikan karakter Islam juga dapat meningkatkan empati, kepedulian, dan keberanian siswa untuk melawan bullying. Oleh karena itu, sekolah berasrama perlu memperkuat pendidikan karakter Islam dalam kurikulumnya dan mengintegrasikannya ke dalam kegiatan sehari-hari di sekolah. Kesimpulan dari penelitian ini adalah bahwa pendidikan karakter Islam memiliki urgensi yang penting dalam mengantisipasi perilaku bullying di sekolah berasrama. Oleh karena itu, pendidikan karakter Islam harus menjadi bagian yang penting dalam kurikulum pendidikan di sekolah berasrama untuk membentuk perilaku siswa yang baik dan mengurangi perilaku bullying di sekolah.
Revista 5ª edição
Authors: Izabel Lima Lorena
Published: June 2023

O relato de experiência ora apresentado tem como objetivo descrever o projeto de extensão Revista 5ª Edição, desenvolvido no Instituto Federal do Paraná - Campus União da Vitória. A proposta da criação de uma revista multidisciplinar justifica-se pela necessidade de, por um lado, criar espaços de protagonismo estudantil e registrar narrativas contra-hegemônicas de produção de sentidos e de saberes; por outro integrar as práticas de escrita às modificações globais no processamento de linguagens híbridas. Assim, o projeto tem como finalidade proporcionar um espaço de produção escrita, reflexão e intercâmbio de informações entre os alunos, servidores e comunidade em geral. Trata-se de uma revista gerida, escrita e produzida pelos alunos e para os alunos e comunidade externa, fundada nas noções de inteligência coletiva - em que o saber é fluxo, conexão de ideias, projetos e conhecimentos - e nas noções de produção colaborativa, pois conecta e socializa experiências, além de servir como vitrine das ações dos alunos em suas práticas de arte, lazer e estudos. Nesse texto, a proposta é: descrever as principais etapas de criação da Revista, problematizando-os com base nas noções de educomunicação (HERNÁNDEZ, 1988) e do letramento (SOARES, 1999); e apresentar alguns dos resultados do projeto. A revista busca ainda dar voz aos estudantes, propondo práticas e narrativas contra-hegemônicas.
Contribuições da neurociência na garantia de direitos sociais
Authors: De Betio Pereira Darlene Maria
Published: June 2023

O presente artigo analisa o papel do neuropsicopedagogo institucional e as contribuições das neurociências na socialização de conhecimentos. O método de investigação foi o estudo de caso nos espaços não escolares de educação. A hipótese que orientou o trabalho foi: o trabalho desenvolvido pelo neuropsicopedagogo institucional auxilia no desenvolvimento cognitivo e potencializa as habilidades do público-alvo em vulnerabilidade social (crianças e adolescentes). Aplicou-se um instrumento de pesquisa ao público-alvo de dois centros de referência em atendimento a indivíduos em vulnerabilidade social (CRAS e Casa de Atendimentos Sociais), bem como se aliou este a um arcabouço teórico fundamentado nas neurociências e no papel do Neuropsicopedagogo Institucional na Educação Social. Inferiu-se que a inserção deste profissional em espaços não escolares é primordial no sentido de potencializar a reintegração pessoal, social e educacional do público-alvo através da identificação, diagnóstico, reabilitação e prevenção das dificuldades e distúrbios da aprendizagem.
Computational Fluid Dynamics Simulation of Oil-Water Batch Transport in a Pumpless Virtual Flow Loop
Authors: Xie Lei , Mao Gangtao , Wang Kai , Li Zhiping
Published: June 2023

Batch transportation of oil and water is a new transportation method in oil and gas gathering and transportation pipelines. Its corrosion inhibition effect has been preliminarily verified in a horizontal pipe experiment. However, achieving overall visualization in traditional loops is difficult, resulting in limited flow pattern classification and analysis of influencing factors. Combining the advantages of the traditional flow loop and the wheel flow loop, we introduce in this paper a round-head straight pipe loop and analyze the influence of key factors on the evolution of the flow pattern of the oil-water interface and the dimensionless length of the oil-water film (L~o, L~w) on the pipe wall through computational fluid dynamics (CFD) numerical simulation. The results show that the batch transportation of oil and water using the round-head straight pipe loop is more in line with the flow characteristics of oil and water two-phase flow in gathering pipelines. Three distinct three-layered flow patterns were identified, which are Flow Pattern I (oil-in-water in the upper layer, annular flow in the middle layer, and oil as the annular phase, water as the core phase, and oil-in-water in the lower layer, abbreviated as DW/O-AN-DW/O), Flow Pattern II (oil phase in the upper layer, annular flow in the middle layer, water as the annular phase, oil as the core phase, and oil in the lower layer, abbreviated as O-AN-O), and Flow Pattern III (oil phase in the upper layer, water-in-oil dispersion flow in the middle layer, and oil in the lower layer, abbreviated as O-DO/W-O). Additionally, parametric analysis reveals that the velocity of the rigid body (ν) has the greatest influence on the coverage rate of the oil film on the pipe wall, followed by the viscosity of crude oil. The density of crude oil has the least influence. The round-head straight pipe loop model offers an accurate simulation of the process of oil and water batch transportation in actual production pipelines. Therefore, the corrosion mitigation efficiency increases with the increase in oil viscosity when the viscosity of the oil lies within the range of 0.01–1 Pa·s. This increase is due to the formation of a more stable oil film on the pipe wall at higher viscosities. When the speed of the rigid body ranges from 0.5 to 1 m/s, due to the small fluid velocity, the erosion effect on the oil film on the pipe wall is relatively small, and the corrosion mitigation efficiency remains stable within a wide range.
A case of primary orbital lymphoma manifested as increased intraocular pressure
Authors: Sun Miaomiao , Xu Yincong , Zhou Zhongyou , Wu Jiale , Han Jiangzhou , Xiong Zhaohui
Published: June 2023

Background
Orbital lymphoma may occur with or without systemic symptoms. Lymphoma can influence any different soft tissue structure in the orbital cavity except the orbital bone, and exhibit similar clinical and imaging features to other orbital diseases, so it is often misdiagnosed. The pathogenesis of lymphoma is closely related to the prognosis. Early diagnosis of the disease is beneficial to the definition and treatment of the disease, and can increase the survival time of the patient.
Case presentation:
An elderly man presented to local hospital with sudden eyelid swelling and vision loss in his left eye. During the follow-up treatment, the intraocular pressure of the patient's left eye increased gradually and the visual acuity gradually decreased to no light perception. We performed CT-guided puncture of the orbital mass. The pathological findings suggested small cell malignancy. Combined with the clinical manifestations and signs, the patient was considered to be ocular non-Hodgkin diffuse large B-cell lymphoma. Then the patient was given combined chemotherapy and radiotherapy. After the treatment, the patient's eye swelling and pain were significantly improved.
Conclusions
To the best of our knowledge, this is one of the few described cases of orbital lymphomas that begin with increased intraocular pressure.
The effect of cognition in combination with an ACBT on dyspnea-related kinesiophobia in patients with moderate to severe COPD: Non-randomized controlled trial
Authors: Cai Shasha , Yao Jinlan , Han Maomao , Luo Xiaolin , Yu Yudi , Lu Xiaorong , Xiang Xinyue , Huang Lihua
Published: June 2023

Background
The majority of patients with chronic obstructive pulmonary disease (COPD) have a catastrophic perception of dyspnea and avoid physical activity, with moderate to severe COPD patients exhibiting more pronounced kinesiophobia. The fear-avoidance model suggests that kinesiophobia can be alleviated by reducing dyspnea symptoms and altering the catastrophic perception of dyspnea as an illness. However, we discovered that single inspiratory muscle training and cognitive change have limitations. This study combined cognition and exercise to examine the efficacy of cognitive therapy based on social cognitive theory combined with an active cycle of breathing technique in reducing dyspnea-related kinesiophobia in patients with moderate to severe COPD.
Methods
This research involved 106 participants. The control group (N = 53) got standard nursing, whereas the intervention group (N = 53) received cognitive combined with active cycle of breathing technology intervention for 8 weeks. The breathlessness beliefs Questionnaire and other secondary outcomes were collected at baseline (T0) and 8 weeks after intervention (T2), and patients' breathlessness beliefs questionnaire were re-assessed at 4 weeks after intervention (T1) and 4 weeks after completion of all therapies (T3).
Results
The between-group effects, within-group effects, and interaction effect of BBQ, BBQ-SF, and BBQ-AA scores in the intervention group were statistically significant (P<0.05) when compared to the control group. The intervention group's six-minute walk distance was significantly higher than the control group's at the end of the 8-week intervention, and the intervention group's mMRC, BODE index, HADS total score and each dimension score, and CAT score were significantly lower than the control group's (P<0.05), and the differences between the two groups before and after the intervention were statistically significant (P<0.001). Only the difference in FEV1% score before and after intervention was statistically significant (P<0.001) in the pulmonary function index, whereas the changes in FVC, FEV1, and FEV1/FVC scores were not (P > 0.05).
Conclusion
The misconception of dyspnea in COPD patients served as the starting point for this study, which integrated cognitive and exercise training. The combined intervention substantially improved dyspnea-related kinesiophobia in patients with moderate to severe COPD, and the effect remained significant when the intervention duration was extended. Furthermore, it may enhance dyspnea and quality of life, increase exercise capacity, and lower the BODE index.
Trial registration
Chinese Clinical Trial Registry, ID: ChiCTR2200058498, registered on 10/04/2022.
Magnetic field effects on wave dispersion of piezo-electrically actuated auxetic sandwich shell via GPL reinforcement
Authors: Mahinzare Mohammad , Rastgoo Abbas , Ebrahimi Farzad
Published: June 2023

This paper presents an analysis of the wave dispersion of a smart cylindrical shell that is composed of a graphene-reinforced nanocomposite (GRNC) at the top of the shell, functionally graded piezo magnetic material (FGPMM) at the bottom of the structure, and an auxetic core in the center of the shell. When calculating the displacement field of a smart shell, the first shear deformation theory is used as an assumption. In addition, the governing equations of the smart sandwich shell may be derived by using Hamilton's principle and Maxwell's law to determine the electrical and magnetic potential. Therefore, the phase velocity of a cylindrical sandwich shell may be calculated by applying exponential functions to the solution of the governing equations to get the desired result. Last but not least, the phase velocity of a smart shell is represented based on the geometrical parameters such as the thicknesses of the FGPMM layer, the GRNC layer, and the Auxetic core, as well as the physical parameters such as the Winkler foundation, temperature change, FG power index, magnetic potential, and external electric voltage that is shown in each figure.
Desempenho e repetibilidade de características de frutos de acessos de Physalis angulata L..
Authors: Toupe Arsene Mariano Sebastien , Lima Jefferson Souza , Souza Ian de Oliveira , de Souza Erison Martins , Passos Adriana Rodrigues , Silva Luiz Cláudio Costa
Published: June 2023

The Physalis angulata L. species, better known in Brazil as camapu, is most found in the northern regions of the country. It is used for human consumption, in medicine and as an ornamental plant. Because of its potential economic and nutritional value, studies have carried out to known the genetic variability of fruit traits. Repeatability is the fraction of phenotypic variation that is due to permanent genetic and environmental factors. The estimation of repeatability coefficient allows breeders to estimate the ideal number of measurements for a trait. This work aims to evaluate the performance of P. angulata accessions and to estimate the coefficients of repeatability and minimum number of repetitions for fruit characteristics, in two environments and two seasons. The present work was conducted at the Horto Florestal Experimental Unity of Universidade Estadual de Feira de Santana, using seven accessions of P. angulata from the Germplasm Collection of LAGEM/UEFS. Four experiments were conducted, two in the experimental field and two in the greenhouse, in an entirely randomized design with 24 replicates, using five accessions in the first two experiments, and six accessions in the last two in each environment, totaling 120 and 144 experimental units, respectively. The characteristics number of fruits per plant (NFP), soluble solids content (SSC), longitudinal diameter (LFD) and transversal diameter (TFD) of the fruits, and average fruit mass (AFM) were evaluated. Data were submitted to analysis of variance (ANOVA) and estimates of repeatability coefficients were obtained by ANOVA, principal components (PC), and structural analysis (SA) methods. There was significant variance among accessions for the characteristics LFD, TFD, AFM and SSC in the experimental field, and for TFD, LFD NFP in the greenhouse. Heritability ranged from 61.63–91.91% in both environments. PC showed the highest estimates of repeatability coefficient. The repeatability and determination coefficients by PC analysis ranged from TFD (r = 0.51; R2 = 96.19%) to SSC (r = 0.72; R2 = 98.47) in the field, and from NFP (r = 0.40; R2 = 93.92%) to LFD (r = 0.51; R2 = 79.38%) in the greenhouse. Twenty measurements can achieve 95% and 90% reliability for experimental field and greenhouse experiments, respectively, for the evaluated traits.
Fourier-domain beamforming for Full Matrix Capture Data with Circular Statistics Vector Weighting in Nondestructive Testing
Authors: Chen Yao , Ma Xiaoxiao , Xiong Zhenghui , Chen Junchao , Kang Yaxuan , Lu Chao
Published: June 2023

Total focusing method (TFM) based on full-matrix capture (FMC) is widely used in the field of nondestructive testing due to its high resolution and high signal-to-noise ratio. In order to solve the problems of the slow speed of traditional time-domain total focusing imaging and poor imaging quality, this paper proposes a total focusing imaging method weighted by circular statistics vector (CSV) in the Fourier domain (FD). Firstly, the cosine and sinusoidal components of the instantaneous phase in the undelayed RF signal are extracted, and the coherence factor is established according to the cosine and sinusoidal components in the FD domain. Finally, the total focusing image in the FD domain is weighted. The complexity calculation shows that CSV-weighted imaging in the FD domain has a higher imaging speed than delay-and-sum (DAS) imaging. The DAS total focusing imaging algorithm, FD domain total focusing imaging algorithm, and FD domain CSV weighted imaging algorithm are used to verify the hole and crack defects in brass test blocks, aluminum test blocks, and steel test blocks. The experimental results show that the proposed FD domain CSV weighted imaging map generally shows higher resolution and signal-to-noise ratio, and the algorithm has higher robustness. Also, it has revealed a low computational load.
Associations Between Improvements in Psychological Variables and Subsequent Sick Leave Among Persons Receiving a Multimodal Intervention for Exhaustion Disorder
Authors: de Leur Jakob Clason van , Buhrman Monica , Wallby Kajsa , Karlström Amanda , Johansson Fred
Published: June 2023

Background: The incidence of sick leave due to stress-related disorders such as exhaustion disorder (ED) is high in many economically developed countries. Meanwhile, knowledge about facilitating return to work during clinical interventions for ED patients is still limited. The current study aimed to investigate if improvements in exhaustion symptoms, insomnia, perfectionistic behaviors, psychological flexibility, and perceived work ability during treatment of ED were associated with subsequent sick leave in the year following treatment.
Methods: Using a cohort of 880 ED patients who had participated in a multimodal intervention based on Cognitive Behavior Therapy, we estimated the association between one standard deviation (SD) improvement in treatment-related variables and the rate of net days of sick leave one-year following treatment.
Results: Our results showed that improvements in all treatment-related variables were associated with lower sick leave rates one year following treatment. Improvements in exhaustion symptoms (rate ratio (RR): 0.70 [95% CI 0.66; 0.75]) and self-perceived work ability (RR 0.56 [95% CI 0.50; 0.63]) showed the largest associations to subsequent sick leave.
Conclusions:These findings suggest that interventions that focus on exhaustion symptoms, insomnia, perfectionistic behaviors, psychological flexibility, and perceived work ability during treatment can have meaningful impacts on ED patients' ability to return to work.
Trial registration: Clinicaltrials.gov (Identifier: NCT03360136)
An ocean of stratospheric aerosols after the Hunga Tonga– Hunga Haʻapai volcanic eruption
Authors: Vernier Hazel
Published: June 2023

Volcanic eruptions are key drivers of the natural variability of the Earth’s Climate system. The sulfate aerosols produced by major volcanic events can last for several years and reduce surface temperatures while warming the stratosphere1. However, this “classic” view is now challenged by the January 15th, 2022, Hunga Tonga Hunga Ha’apai submarine eruption. For the first time in the satellite era, a volcano injected material up to the mesosphere2 leading to an increase in the global stratospheric water vapor burden by 10% from seawater injected3. However, no information is available about the chemical properties of the plume. Herein, we show a detailed analysis of the chemical composition of the HTHH plume through a new balloon-based sampling technique. The ion chromatographic analysis of the sampled aerosols shows the presence of sea salts as opposed to a pure sulfate plume alone. The chemical analysis thereby revealed that the HTHH is more complex than initially thought and may explain the unexpected aerosol burden created by this eruption relative to the expected sulfate aerosol produced from the modest 0.6 Tg SO2 injected. These results challenge the current models that simulate the climate impacts of volcanoes.
Coronary tortuosity: a new gender related risk factor?
Authors: Donna Carlo Di , Ricci Francesca , Rellini Carlotta , Pugliese Luca , De Stasio Vincenzo , D'Errico Francesca , Madonna Matteo , Patanè Alberto , Garaci Francesco , Floris Roberto , Chiocchi Marcello
Published: June 2023

Gender differences in cardiovascular disease represent a great challenge for cardiology. Coronary vessel tortuosity is common anatomical feature that shows significant prevalence in women.Tortuosity modifies vessels hemodinamyc; coronary tortuosity is related to helical flow which results in a reduction of myocardial perfusion pressure and in increase of shear stress and microcirculatory resistance. 149 patients (78 males;71 females), with low to intermediate cardiovascular risk and no previous history of CAD, who underwent coronary CT scan were included in this retrospective study. All patients who underwent CCT were admitted to our institution with no cardiac symptoms and low or intermediate cardiovascular risk, according to ESC guidelines. It can be observed that there is a positive, strong and statistically significant relationship between NYHA and all the other variable. In our study we demostrate correlation between coronary tortuosity, diastolic disfunction and symptoms.
Co-enrichment of cancer-associated bacterial taxa is correlated with immune cell infiltrates in esophageal tumor tissue
Authors: Greathouse KL , Stone JK , Vargas AJ , Choudhury A , Padgett N , White JR , Jung A , Harris CC
Published: June 2023

Esophageal carcinoma (ESCA) is a leading cause of cancer-related death worldwide, and Barrett’s esophagus (BE) is a strong risk factor along with smoking. Smoking is well-known to induce microbial dysbiosis and we asked if BE and esophageal microbiomes had shared microbial alterations that could provide novel biomarkers. We extracted DNA from BE tissues (n=5) and tumors of 158 patients in the NCI-MD case control study and sequenced the 16S rRNA gene (V3-4), with TCGA ESCA RNAseq (n = 173) and WGS (n = 139) non-human reads used as validation. We identified four taxa, Campylobacter, Prevotella, Streptococcus, and Fusobacterium as highly enriched in esophageal cancer across all cohorts. Using SparCC, we discovered that Fusobacteriumand Prevotella were also co-enriched across all cohorts. We then analyzed immune cell infiltration to determine if these dysbiotic taxa were associated with immune signatures. Using xCell to obtain predicted immune infiltrates, we identified a depletion of megakaryocyte-erythroid progenitor (MEP) cells in tumors with presence of any of the four taxa, along withenrichment of platelets in tumors with Campylobactor or Fusobacterium. Taken together, our results suggest that intratumoral presence of these co-occurring bacterial genera may confer tumor promoting immune alternations that allow disease progression in esophageal cancer.
Twin Delayed Stochastic Actor-Critic
Authors: Asadolahi Mohammad , Sharifi Arash , Banirostam Touraj
Published: June 2023

In both discrete and continuous domains, model-free reinforcement learning algorithms have been successfully applied to the vast majority of reinforcement learning problems and are the main solution to real world problems. In reinforcement learning problems with continuous action space, state-of-the-art algorithms are extremely sample-inefficient and need lots of training interactions to become proficient, which could be catastrophically expensive and infeasible in real-world problems. So far, frontier algorithms have not used well-defined methods to explore the decision space. Exploring new behaviors is a prerequisite to look for optimal policies. All of the leading algorithms in the field leverage a blind form of exploration added to agent decisions to search for better policies. Such solutions fail to mindfully explore the environment, disrupting the learning process. This makes these algorithms very prone to failing in specific domains. In this research, a novel stochastic Off-Policy Actor-Critic algorithm, TDS for short, is presented. Combining the policy gradient theorem with the deterministic policy gradient, the TDS algorithm can learn how to mindfully explore the environment. The proposed update method enables TDS to learn how to modify the decision stochasticity bonds for each state and action. This is done according to gradients information derived from learning feedbacks. Evaluations in MuJoCo and Box2D tasks show faster convergence or outperform the state-of-the-art algorithms including TD3, SAC, and DDPG in every environment tested.
Development of a novel protocol for enhanced tomato callus formation and growth through the use of medicinal Plant extracts
Authors: sohrabi omid , Hatamzadeh Abbdollah , Ghasemnezhad Azim , Samizadeh Habibollah , Erfani-moghadam Vahid
Published: June 2023

Medicinal plants and their derivatives have been used for centuries in various sectors beyond treatment and nutrition. However, the use of toxic chemicals such as pesticides, fungicides, and herbicides has led to environmental pollution, necessitating the search for eco-friendly alternatives. Medicinal plants and their compounds offer a promising solution due to their naturalness and biodegradability. An in-vitro experiment was conducted at Gorgan University in 2022 to test the impact of six medicinal plant extracts on tomato growth and callus induction. Two concentrations of 50 and 100 mg/L were added to the Murashige and Skoog (MS) medium culture. Results showed a 100% increase in germination speed and an increasing trend in stem length (SL), with the 50 mg/L Juniperus sabina treatment yielding the highest amount. The amount of callus growth (CG) and weight (CW) increased by 50% and over 200%, respectively, with the Taraxacum officinale 100 and Conocarpus erectus 50 mg/L treatments producing the best results. More than 90% callus formation was observed compared to the control. Biochemical analysis revealed that the extracts were rich in phenolic compounds (348 mg/g of total phenol), flavonoids (162 mg/g), antioxidants (61%), and auxin. Antioxidant and plant growth regulators (PGR) content and the stimulation of the plant's defense system likely contributed to the results. Plant extracts also affected the biochemical content of calluses, with the exception of total phenol. Using plant extracts to increase growth and reduce time for callus induction is recommended in tomato tissue culture. However, optimal concentration and combination of medicinal plant extracts for different plant species and growth conditions require further research.
Vitamin D deficiency and bone density in children with celiac disease in southern Iran: An academic tertiary referral center's experience
Authors: Honar Naser , davoodi marzieh , Azizi Mehdi , Saki Forough
Published: June 2023

Objectives
Celiac disease is not limited to the digestive tract. Patients are at high risk for secondary osteoporosis, rendering the monitoring of bone density critical. We aimed to examine vitamin D deficiency and bone density in children with celiac disease.
Methods
This prospective cross-sectional study was conducted in 2018–2019 in the Fars province of Iran. The study population included children with celiac disease referred to Imam Reza Clinic or Namazi Hospital within the study period. Patients were examined for vitamin D deficiency and bone density levels.
Results
The present study included 10 (43.5%) boys and 13 girls (56.5%) with celiac disease. Only two patients were under vitamin D supplementation (8.7%). Growth disorders were the most common reason for referral (78%). Celiac disease in most children was associated with vitamin D, calcium, and parathyroid hormone enzyme activity disorders. Increasing age was associated with vitamin D deficiency. The lumbar and femoral bone density were associated with the puberty stage but not the age or gender.
Conclusions
Considering that the prevalence of osteoporosis and osteopenia is very high in celiac disease patients, a proper screening program should be devised to reduce the injuries caused by undiagnosed bone disorders.
On the Investigation of Interacting Fault Movement in a Viscoelastic Structure
Authors: Kundu Piu , Negi Anil
Published: June 2023

Investigations of the effects of ground deformation due to fault movement on surface and subsurface engineering structures
are important owing to their direct impact on the reduction of earthquake damage. This ground deformation has a great impact on displacement and stress-strain accumulation due to fault movement. In this study, a theoretical model of aseismically creeping, interacting, inclined, buried and strike-slip fault has been considered and the fault model located in a visco-elastic half-space of Maxwell medium. The analytical solution of displacement, stress and strain components in the absence of fault movement and due to interaction between the faults has been obtained by using the correspondence principle in terms of Mittag-Leffler function and Green's function. The obtained results has been studied graphically which may helps us to study earthquake prediction program.
Visit-to-visit blood pressure variability and clinical events in older patients receiving home medical care: The OHCARE study
Authors: Koujiya Eriko , Kabayama Mai , Yamamoto Mariko , Higami Yoko , Kodama Kana , Mukai Sakino , Yano Tomoko , Nako Yumiko , Murakami Naoko , Fukata Yuka , Godai Kayo , Nakamura Toshinori , Hirotani Atsushi , Fukuda Toshio , Tamatani Michio , Okuda Yoshinari , Ikushima Masashi , Baba Yoshichika , Nagano Masahiro , Takeya Yasushi , Rakugi Hiromi , Kamide Kei
Published: June 2023

Background
In recent years, the management of blood pressure (BP) variability and mean BP levels have become more important for hypertensive patients. We investigated the association of visit-to-visit variability (VVV) of BP with clinical events in older patients (about 85 years old) receiving home medical care.
Methods
We included patients who were followed up as part of the Osaka Home CAre Registry (OHCARE) study. OHCARE was a prospective cohort study that targeted older patients receiving home medical care in Japan. We included patients (n = 103) that fulfilled the following inclusion criteria: aged 65 years or older; BP measurements performed on at least three occasions before the baseline date (median 4.78 occasions); BP measurement interval of 16 ± 13 days (median ± 1 standard deviation [SD]). We used SD and coefficient of variation (CV) of systolic blood pressure (SBP) measured at baseline as the VVV of BP. Main outcomes were clinical events including hospitalizations, falling, and death during follow-up.
Results
Regarding the relationship between VVV and clinical events, the rate of hospitalization was significantly higher in the group with the largest SD of SBP than in the group with the smallest. Furthermore, multivariate analysis showed that SD and CV of SBP had independent positive associations with hospitalization.
Conclusions
In older patients requiring home medical care, a higher VVV in SBP may be related to the occurrence of events leading to hospitalizations; thus, our findings suggest that it could be used as a predictive marker.
The Effect of an Adapted Digital Mental Health Intervention for Sickle Cell Disease on Engagement: A Pilot Randomized Controlled Trial
Authors: Parchuri Ektha , Nardo Emily , O'Brien Julia , Crosby Lori , Porter Jerlym , Palermo Tonya , Nikolajski Cara E , Treadwell Marsha , Hillery Cheryl , Szigethy Eva , Jonassaint Charles
Published: June 2023

INTRODUCTION: Despite promising outcomes, lack of engagement and poor adherence are barriers to treating mental health using digital CBT, particularly in minority groups. After conducting guided focus groups, a current mental health app was adapted to be more inclusive for minorities living with SCD.
METHODS: Patients between the ages of 16–35 with SCD who reported experiencing anxiety or depression symptoms were eligible for this study. Once enrolled, participants were randomly assigned to receive one of two versions of a mental health app 1) the current version designed for the general population and 2) the adapted version. Baseline measures for depression, anxiety, pain and self-efficacy were completed at the start of the study and again at postintervention (minimum 4 weeks).
RESULTS: Compared to baseline, pain (p = 0.03), self-efficacy (p = 0.007) and depression symptoms (p = 0.016) improved for the group that received the adapted app. Regardless of group assignment, a positive relationship (r = 0.47) was shown between app engagement and a change in depression symptoms (p = 0.042).
DISCUSSION: Target enrollment for this study sought to enroll 40 participants. However, after difficulties locating qualified participants, enrollment criteria were adjusted to expand the population pool. Regardless of these efforts, the sample size for this study was still smaller than anticipated (n = 21). Additionally, irrespective of group approximately 40% of participants did not engage with the app. However, despite a small sample size and poor engagement, participants in the intervention group displayed better outcomes and showed trends for greater app interaction.
CONCLUSION: These promising results should encourage future researchers to continue exploring ideal adaptations for implementing digital CBT in minority populations. Future studies should also consider implementing post-intervention surveys to help identify common factors relating to a lack of engagement.
Test-retest reliability and practice effect of the Test of Visual Perceptual Skills-4th Edition for individuals with schizophrenia
Authors: Chiu En-Chi , Lee Shu-Chun
Published: June 2023

Background
The Test of Visual Perceptual Skills-4th Edition (TVPS-4) is widely used for repeated measures of visual perception. This study aims to examine the test-retest reliability and practice effect of the TVPS-4 in individuals with schizophrenia receiving care in community psychiatric rehabilitation facilities.
Methods
A repeated assessment design was employed, involving 80 participants. Test-retest reliability was evaluated using the intraclass correlation coefficient (ICC). Minimal detectable change (MDC) values were calculated at 95%, 90%, and 80% confidence levels. The MDC% was determined based on the MDC with 95% certainty. Cohen's d effect sizes and paired t-tests were utilized to assess the practice effect.
Results
The ICCs of the overall scale and the seven subscales of the TVPS-4 were 0.93 and 0.59–0.84, respectively. The MDC95 (MDC%), MDC90, and MDC80 ranged from 4.7–16.3 (13.2–34.8%), 3.9–13.6, and 3.1–10.6, respectively. Cohen’s ds were 0.06–0.26 and paired t-test showed significant differences in scores of the overall scale and the four subscales (p < 0.05).
Conclusion
The TVPS-4 has acceptable test-retest reliability and trivial to small practice effect, and the MDCs at different confidence levels can be used to interpret the score changes at a particular level of certainty for individuals with schizophrenia.
Long short-term prediction guides human metacognitive reinforcement learning
Authors: Lee Sang Wan , Kim Dongjae , Lee Jee Hang , Jung Wooseok , Kim So Hyun
Published: June 2023

Long-term prediction ensures stable but slow learning. Short-term prediction is fast but deemed to be risky in context-changing environments. To understand how humans resolve this conflict, we fitted nine biologically plausible reinforcement learning models to 82 human behavior data using a human-model policy matching method. One meta-RL model replicates subjects' context-dependent behavior, passing underfitting and overfitting tests. The same model survived a generalizability test simulating various Markov decision tasks and an adaptation test in which task structure, reward, and uncertainty change unexpectedly. Critically, the model’s ability is attributed to long- and short-term predictions about state transition and reward. Quantitative analyses revealed that conventional instant prediction error and its underlying long-term baseline are sufficient for context embeddings. These findings generate a long short-term prediction hypothesis: humans translate short-term into long-term predictions for context generalization while self-evaluating their long-term predictions to adjust short-term predictions. This creates a virtuous cycle of metacognitive generalization-adaptation.
Spatiotemporal Expression and Control of Haemoglobin in Space
Authors: Borg Josef , Beheshti Afshin , Kim JangKeun , Damle Namita , Meydan Cem , Muratani Masafumi , Overbey Eliah , Ryon Krista , Zwart Sara , Smith Scott , Tierney Braden , Mason Christopher , Borg Joseph
Published: June 2023

The role of the space environment in activating a diverse set of genes involved in regulating key cellular pathways is now widely recognized. This includes genes associated with blood control and erythropoiesis, with a particular emphasis on those involved in globin chain production. The comprehensive investigation of haemoglobin biology provides an intriguing model for studying space omics, as it has been extensively explored at multiple -omic levels, spanning DNA, RNA, and protein analyses, in both experimental and clinical contexts. In this study, we examined the developmental expression of haemoglobin over time and space using a unique suite of multi-omic tools available on NASA GeneLab. We analyzed human data from the NASA Twins Study, the JAXA CFE study, and the Inspiration4 mission. Our findings reveal significant variations in globin gene expression corresponding to the distinct spatiotemporal characteristics of the collected samples. This study sheds light on the dynamic nature of globin gene regulation in response to the space environment and provides valuable insights into the broader implications of space omics research.
A Technique to Forecast Pakistan’s News using Deep Hybrid Learning Model
Authors: Ihsan Rukhshanda , Khurshid Syed Khaldoon , Shoaib Muhammad , Ali Sadia , Mahnoor Sana , Syed Muhammad Hamza
Published: June 2023

Forecasting future events is a challenging task that can have a significant impact on decision-making and policy-making. In this research, we focus on forecasting news related to Pakistan. Despite the importance of accurate predictions in this field, there currently exists no dataset for forecasting Pakistani news, specifically with regard to politics. In order to address this gap, our research aims to create the first Pakistani news dataset for forecasting Pakistan news that is mostly related to the politics of Pakistan. This dataset was collected from various sources, including Pakistani news websites and social media platforms, as well as frequently asked questions about Pakistani politics. We develop a forecasting model using this dataset and evaluate the effectiveness of cutting-edge deep hybrid learning techniques incorporating neural networks, random forest, Word2vec, NLP, and Naive Bayes. To the best of our understanding, no research has been done on the application of a deep hybrid learning model—a blend of deep learning and machine learning—for news forecasting. The accuracy of the forecasting model is 97%. According to our findings, the model's performance is adequate when compared to that of other forecasting models. Our research not only fills the gap in the current literature but also presents a new challenge for large language models and has the potential to bring significant practical advantages in the field of forecasting.