bluuebunny/crossref_metadata_2025 huggingface dataset:
Tratamento da neurocisticercose via cirurgia minimamente invasiva: análise da literatura
Authors: De Souza Arthur Vinicios Araújo , Linhares Mateus Rodrigues , Araujo Philipe de Pina , Concentino Renata Alcanfor , Iqueda Renato Magalhães , Pucci Leonardo Ferreira , De Abreu Fernanda Garzedim Santos , De Sousa Renan Marques Dias , Jalal Muhamad Kalid , Mamede Thiago Ferreira , De Moreira Brandon Andrade , De Sá Ana Luysa Rosa , Galvão Rodrigo Góes de Oliveira , Pereira Alisson Matheus Batista , Oliveira Beatriz Dias , Lima Bruna Alves , Oliveira Kethleen Sunamita Dias , Neto Jocelino Antônio Laranjeiras , Maciel Caroline Vianna , Rosa Artur Afonso
Published: January 2024

A neurocisticercose (NCC) é uma doença  resultante da ingestão dos ovos da Taenia solium. Uma vez eclodidos, esses ovos podem percorrer a corrente sanguínea e se alojar no tecido cerebral, desencadeando sintomas como convulsões, hidrocefalia e, em casos mais graves, resultando em óbito. Além disso, cistos podem ser localizados em regiões fora do tecido cerebral principal, incluindo o quarto ventrículo. O diagnóstico da NCC tem sido um desafio global devido à carência de exames histopatológicos conclusivos, achados clínicos e de imagem atípicos, bem como à baixa sensibilidade e especificidade dos testes imunológicos. Nesse contexto, a neuroimagem desempenha um papel crucial no diagnóstico da NCC, representando a principal ferramenta para identificar a presença e estágio da doença. Realizou-se uma revisão sistemática de literatura por meio da plataforma pubmed, com seleção e análise criteriosa dos artigos, a fim de elucidar o tratamento e pós-operatório na modalidade terapêutica da neurocisticercose. Nesta revisão foi identificado que existem limitações na literatura mundial sobre o devido tema, por falta de diagnósticos definitivos em países sub e em desenvolvimento e pela complexidade e latência da doença. Notou-se que os tratamentos que existe algumas variações terapêuticas, sendo: O padrão atual de tratamento da neurocisticercose intraventricular (NIV) é a derivação liquórica de emergência com ou sem excisão microcirúrgica do cisto, seja por corredores transcorticais ou transcalosos e utilizando a depender da necessidade os anti-helmínticos, esteroides e antiepilépticos. Foi observado na análise da literatura que a medicação anti-helmíntica pode ser eficaz, mas é demorada e nem sempre resolve o problema, especialmente em casos de hidrocefalia. A derivação do LCR é frequentemente necessária para tratar a hidrocefalia, mas apresenta uma alta taxa de falha e pode requerer revisões. A endoscopia é uma opção, mas pode ser arriscada em casos de cistos aderentes e pode precisar ser convertida para uma craniotomia aberta. A craniotomia (CPQ) envolve a remoção cirúrgica do cisto e é frequentemente recomendada, especialmente em casos intraventriculares. Foi observado aumento de procedimentos minimamente invasivos devido aos seus benefícios de poupar estruturas saudáveis durante o procedimento, principalmente em NCC intraventricular. A análise busca contribuir para um entendimento mais aprofundado dos benefícios e desafios do tratamento no contexto da neurocisticercose.
Heritage Values and Community Perception: A Look Into the Historic Ruins of Dinajpur Rajbari
Authors: Madhury Murchana , Sarker Labanya
Published: January 2024

The establishment of the value and effective protection of historical ruins comprises a subject of rising interest, as evidenced by an increasing amount of research involving several disciplines. In Bangladesh, debates on the relevance of such abandoned, degraded, deformed, or empty structures—unlike other intact monuments in heritage studies—rarely take into account the attitude of the locals towards these ruins. Analyzing the case of Dinajpur Rajbari, Bangladesh, the paper intends to explore the value ascribed to historic ruins by the surrounding community. The study uses a case study approach built on Mason’s value typology, which has widely contributed to the identification of the significance of heritage sites. Using a mixed research method, data were collected through field observation, semi-structured interviews, and focus group discussions with 100 respondents selected from members of the local community. The article concludes by informing policymakers and heritage conservators of the position of community perception and promoting its integration into the development of management policies for these historical ruins.
Justiça social: o argumento de Hayek e o exemplo de Gama
Authors: Caprioli Efraim , Sanches Raquel Cristina Ferraroni , Nieddermeyer Henrique Lacerda
Published: January 2024

O desenvolvimento dos direitos humanos nas últimas décadas é marcado por uma série de conquistas e na positivação de direitos fundamentais no Brasil e no mundo. Junto com esse avanço ocorre o surgimento dos direitos que, oriundos de demandas sociais, pretende alcançar o bem-estar social por meio do termo “justiça social”. Hayek argumenta que, a união das palavras para compor o termo faz com que se perca o significado de justiça e que esgote o termo social, tanto pela ausência de sentido semântico das palavras, como no resultado do que se procura atingir. Hayek também argumenta que essa demanda de direitos por setores específicos tem como consequência o enfraquecimento da democracia. Por meio de uma análise dos poemas e realizações do ícone brasileiro Luiz Gama, podemos observar na prática o argumento de Hayek. Com essa análise procuramos evidenciar que o sucesso de Gama se dá por sua atuação defendendo a liberdade para todos e não só a uma parcela da sociedade. O método utilizado para a elaboração do artigo foi o dedutivo, a partir de pesquisa documental e bibliográfica.
A prescrição off label de medicamentos nos contratos de plano de saúde: uma revisão sistemática da jurisprudência do Superior Tribunal de Justiça
Authors: Lima Éfren Paulo Porfírio de Sá , Amorim Andrew Rios
Published: January 2024

O presente artigo tem como escopo analisar, por meio da pesquisa das decisões colegiadas proferidas pelo Superior Tribunal de Justiça (STJ), a lide processual envolvendo o paciente, o médico assistente e a operadora de plano de saúde acerca do fornecimento/custeio de medicamentos prescritos na forma off label. Para tal objetivo, o trabalho foi dividido em três etapas. Primeiramente, através da revisão bibliográfica da literatura, buscou-se conceituar a prescrição off label de medicamentos, discutindo-se a sua origem, sua aplicação e suas consequências tanto para o paciente como para o médico prescritor. Cumprida essa etapa, buscou-se entender o papel do terceiro agente envolvido na lide: a operadora de plano de saúde, o que se deu por meio do estudo das características essenciais do contrato de plano de saúde e por meio de um breve estudo comparativo entre o posicionamento adotado no direito português e no direito brasileiro, bem como buscou-se estudar os diversos posicionamentos existentes acerca da possibilidade ou não do plano de fornecer o medicamento off label. Finalmente, os dados da revisão sistemática da jurisprudência do STJ são apresentados, chegando-se à conclusão de que o referido tribunal, por unanimidade, reconhece o dever de fornecimento da medicação off label ao paciente segurado pelo plano. Entretanto, o resultado da revisão sistemática da jurisprudência do STJ mostra um aparente conflito entre as decisões pacificadas no âmbito dos julgamentos envolvendo medicamentos off label com a decisão nos Embargos de Divergência em Recurso Especial nº 1.886.929 – SP, no qual restou compreendido o caráter taxativo do Rol de Procedimentos e Eventos em Saúde da ANS e, por isso, ocasionou uma reação imediata do Congresso Nacional mediante a aprovação da Lei nº 14.454/22, que modificou o entendimento do STJ e caracterizou o Rol da ANS como exemplificativo.
The Gut-brain axis: the role of gut microbiome in Alzheimer's disease
Authors: Guo Zhen
Published: January 2024

Alzheimer's disease is one of the most severe and wide-spread neurodegenerative diseases in the world. WHO estimates that more than 47 million people (8.1% of women and 5.4% of men over the age of 65) are currently living with dementia. Despite the long history and wide impact in humans of AD, the disease remains in mist. Until now, we cannot determine which factors cause AD and how to find a cure. There is several hypotheses about the pathogenesis of AD, of which cholinergic hypothesis and Nucleic acid oxidation hypothesis are two of the most insightful ones. Besides, increasing evidence suggests the intimidate role of gut microbiome in the development and mitigation of Alzheimer's disease. The bidirectional link between the gut and the brain is note-worthy, offering a potential insight to future investigation on AD.  To fully understand the role of gut microbiome in process of Alzheimer’s disease, this review illustrates pathogeneses of AD and the procedure of several important pathogenetic factors like high blood pressure, diabetes and aging should be discussed. Further application of gut microbiome can be a drug target for AD: scientists extract a chemical called sodium oligomannate for balancing gut microbiome to treat mild to moderate AD.
Advances in dengue virus vaccines and therapeutic monoclonal antibodies
Authors: Ma Yunchuan
Published: January 2024

The prevalence of dengue fever (DF) in many countries has become a global burden. The pathogen, dengue virus (DENV) contains four serotypes, and oftentimes the antibody-dependent enhancement (ADE) due to the insufficient and imbalanced host immunity leads to severe dengue symptoms in heterologous secondary infections, posing a major difficulty ahead of modern medicine. Two technical routes, vaccine and monoclonal antibody (mAb) have been widely explored and testified at various levels. Tetravalent vaccines, especially chimeric live-attenuated viruses (LAV), have been proven to induce a relatively well-rounded immune response, while other categories including virus-like particle (VLP) are also of high potential. Therapeutic mAbs also have been shown to target epitopes that can be cross-neutralizing, covering not only individual structural and non-structural proteins but also quaternary conformation of virion surface. Undoubtedly limitations of previous research have directed the refinement of vector design, efficacy assessment, and other processes, although several challenges still exist today.
Epidemiological Characteristics and Prevention of COVID-19
Authors: He Ruihang
Published: January 2024

At around March of 2020, the new coronavirus, now named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), spread fast across the world. The symptoms of SARS-CoV-2, such as fever, cough, difficult breathing, and pneumonia were similar to the infection of influenza virus, which mislead the public at the beginning of the virus outbreak. In addition, social issues in aspects of economy, environment, and resource distribution should be considered as factors of what lead to the global pandemic as well. This article briefly introduced the pathology of COVID-19, summarized factors that lead to the global pandemic from three aspects: the complexity and variation of the virus, the validity of the vaccine, and the action and countermeasures of the public health system. Then, this article discussed the countermeasures aim from public health system and individual at this pandemic particularly, providing some ideas for pandemic of infection diseases in future.
Immune Checkpoint Inhibitors Combined with Chemotherapy in The Treatment of Lung Cancer
Authors: Ding Jinheng
Published: January 2024

Immune checkpoint inhibitor (ICI) therapy is the most commonly used immunotherapy regimen. The clinical application of this medicine has been authorized for the treatment of several neoplasms such as melanoma, renal, head and neck, bladder, etc. Lung cancer treatment has witnessed significant advancements, positioning it as a pivotal component within the broader framework of comprehensive lung cancer management. However, due to the heterogeneity of tumors and the intricacy of the microenvironment of tumors, the effective rate of ICIs alone is low in non-selected patients. Surgery, chemotherapy, radiotherapy, targeted therapy, and other treatments can have synergistic effects with immunotherapy, and combination therapy has become a hotspot for exploration. This article centers on the research advancements in the therapeutic approach of combining immune checkpoint inhibitors (ICIs) with chemotherapy. This text offers an introductory overview of the distinct mechanisms of action associated with these two treatment modalities, highlighting the significance of their combined use in the context of lung cancer treatment. The objective is to offer a reference point for future clinical treatments of lung cancer.
Design and output spectral peak power optimization of E-band fiber-amplified spontaneous emission spectra
Authors: Wang Haishuo , Yu Tiancheng , Yang Zhe
Published: January 2024

Fiber optic amplifiers will improve the power of signals propagating in optical fibers, usually using doped ions as amplifiers. The bismuth-doped fiber amplifier can amplify the current E-band signal light, which is less used, and provide a solution to enhance the communication transmission capacity.In this essay, Matlab is used as a research tool, and the bismuth-doped fiber amplifier is selected, and the energy level system is a three-energy levelThe 830 nm-wavelength pumping source amplifies the signal light at 1390 nm. The bismuth-ion velocity and power amplification propagation equations are established, and the amplified spontaneous radiated optical power is calculated. Amplified spontaneous radiation optical power, and through the calculation and simulated annealing algorithm to derive the amplified spontaneous radiation optical power amplification with the doping concentration and fiber length spectrum, in the fiber length of 3.3m and the number of doped particles of 9.1 * 10^25 to obtain the maximum optical power of 7.95*10^-9W.
Lentiviral Vectors in CAR-T Cell Manufacturing: Biological Principles, Manufacturing Process, and Frontier Development
Authors: Yang Ge
Published: January 2024

Chimeric antigen receptor T cell (CAR-T) therapy, as the preeminent strategy in immunotherapy, has conferred benefits upon numerous cancer patients. Currently, there are six CAR-T therapies approved by the Food and Drug Administration (FDA), while the China National Medical Products Administration (NMPA) has approved three. The manufacturing process for CAR-T cells (CAR-Ts) entails using lentiviral vectors (LVVs), which are efficacious in transducing functional genes to both dividing and nondividing cells. Also, LVVs exert their capacity to integrate relatively large segments of DNA. Despite this fact, LVV-based CAR-Ts production can prove prohibitively expensive, and the yield of LVV can be further enhanced. In recent years, in-vivo generation of CAR-Ts has attracted significant attention since it stands to eliminate the ex-vivo isolation and activation process for T cells, thereby decreasing the cost and time involved in production. In view of this, this review summarizes the biological principles of LVVs and their manufacturing process, which encompasses lentiviral vector production, T cell isolation and activation, and CAR-Ts production. Additionally, the cutting-edge developments associated with LVVs are outlined herein, offering direction for the production of the next generation of CAR-Ts.
Listing and Comparing the Immunogenicity, Safety, and Effectiveness of 9vHPV Vaccinations for Different Age Groups: 9-15 Years Old, 16-26 Years Old, 27-45 Years Old
Authors: Jiang Mengci , Lin Zian
Published: January 2024

The effectiveness of the Human Papillomavirus (HPV) vaccination in preventing high-risk HPV infections and accompanying serious vaginal, cervical, and vulvar disorders was verified. The development of the 9-valent HPV(9vHPV) vaccine yields greater coverage versus the quadrivalent (qHPV) vaccine. This study aims to assess the 9vHPV from immunogenicity, safety, and effectiveness in three different age groups respectively: 9-15 years old, 16-26 years old, and 27-45 years old. This paper searched PubMed and Embase databases to include related clinical trials of these three age groups and ensure a large-scale study population. Immunogenicity analysis for different age groups reported that the geometric mean titers (GMTs) decreased with age but could still stimulate robust and effective immune responses. The antibody levels of the subjects significantly increased to reach protective levels and persisted for a long time after vaccination. Besides, the 9vHPV vaccine has a high protective effect against the infection of nine subtypes of HPV. Both HPV infection rates and rates of associated diseases significantly decreased versus those who did not receive the vaccine. Additionally, the outcomes also demonstrated that the safety of the 9vHPV vaccines was good across all age groups. The intensity of most reported injection-site adverse events (AEs) and vaccine-related systemic AEs were not serious. Serious adverse reactions are very rare. In total, immunogenicity, efficacy, and safety in different age groups of the 9vHPV vaccination are overall good. These findings provide scientific evidence for the immunization of the 9vHPV vaccine and recommend the optimal age for vaccination.
The Chemical Constituents and Application Status of Radix Astragali
Authors: Zhao Saichula
Published: January 2024

Radix Astragali, a highly renowned herbal medicine, boasts a venerable history within the realm of the traditional Chinese medicine. Its abundant therapeutic value has elicited widespread scholarly attention. This paper summarizes the chemical composition and pharmacological effects of the Radix Astragali and explores its application status in aquaculture and medical cosmetology. Radix Astragali is rich in chemicals. Flavonoids, saponins and astragalus polysaccharides are the main active components of Radix Astragali. These ingredients have many pharmacological effects, such as antioxidant, anti-inflammatory, antitumor, and immunomodulatory effects. In addition, Radix Astragali as a feed additive can improve the growth and development, and reproductive function and immune health of livestock and poultry. In the medical beauty industry, Radix Astragali has also been developed into a product with effects such as the sun protection and skin repair. These studies provide a basic basis for the research and application of astragalus and its active ingredients.
Current targets and treatments of schizophrenia
Authors: Ding Yutong , Gao Haoxiang , Liu Zhaoyi , Xu Xinyi
Published: January 2024

With the improvement of the level of social and economic development, mental illness has received more and more attention and attention. Among them, schizophrenia, as a common mental illness, seriously impairs the mental activity and social function of patients, and its lifetime prevalence rate is about 1%, bringing a heavy social burden. Schizophrenia is a disease that involves a variety of symptoms, including cognitive, behavioral, and emotional, and its symptoms vary greatly from patient to patient, even at different stages of the disease in the same patient. At present, the specific pathogenesis of schizophrenia is still unclear, and it is generally believed that it is caused by structural and functional abnormalities of the central nervous system, which is the result of the interaction of genetic and environmental factors. Schizophrenia is a mental disorder disease, It can cause a person to be out of control in a number of ways and is a common and popular mental illness in the world, and recently, with advances and pioneering in the field of medicine, more and more neuroscientists and medical doctors are beginning to development into this field. This review systematically introduces several pathways related to schizophrenia disorders, anti-psychotic medications, and the GABA and schizophrenia. This review also introduces three generations Antipsychotics and further discusses role of GABA in the pathogenesis of schizophrenia.
Ethical Issues of Elders During The COVID-19 Pandemic
Authors: Zhou Yanming
Published: January 2024

The Elders are facing severe marginalization in modern society, especially during the pandemic. It is because of this marginalization and lack of resources, that the elders face many ethical issues in their daily life. Under the COVID-19 Pandemic, ethical issues dealing with vaccines, priority, and isolation are really worth attention. This research collects some of the main ethical issues found during the COVID-19 pandemic, focuses on finding the root cause of each, and gives a possible future alternative. This research brings up three major ethical issues, each discussing priority, vaccination, and isolation. As a research based on other expert’s findings, this research uses pieces of evidence to prove the importance and the severity of the ethical issues listed above. The central aim of this research is to inform people about the existence of such problems, hence, suggesting the importance of necessary solutions, such as communication.
Application of Aspirin for Rheumatoid Arthritis and Myocardial Infarction Treatment
Authors: Lin Zihan
Published: January 2024

With the intensification of the aging process of the population, the disease problems of the elderly are particularly prominent. Rheumatoid arthritis and myocardial infarction are common diseases in the elderly. The main component of aspirin has been used to treat fever since 1763, and then the role of aspirin was discovered by humans. In modern daily life, aspirin is used for anti-inflammation, pain relief, and inhibition of thrombus formation. The subject of this research is how recent experiments demonstrate the effectiveness of aspirin for these two diseases. Research done by different teams has shown that aspirin inhibits a catalyst called COX that catalyzes the production of prostaglandins for rheumatoid arthritis treatment, leading to the relief of skeletal muscle pain and inflammation. In the treatment of myocardial infarction, aspirin prevents the accumulation of platelets to reduce the formation of thrombosis. Among the drug that can treat these two diseases, aspirin can be said to be the most effective drug with the least side effects.
Application of Different Cell Therapies in the Treatment of Covid-19
Authors: Li Yunzi
Published: January 2024

Covid-19, which erupted in Wuhan, China, in 2019, was highly contagious and caused panic. covid-19 has a sequelae, and the World Health Organization reports that about 10 to 20 percent of crown infections have new crown sequels, including exhaustion, overheart movement, shortness of breath, cognitive difficulties, chronic pain, sensory function, muscle weakness, etc. Research institutions such as the United States, the United Kingdom, the Netherlands and other research institutions have released a considerable number of new crown sequels in their own country, and some of the population is already unable to work. There are still no systematic treatment, only some of the symptoms proposed based on the symptoms, these traditional therapies do not treat the sequelae, so some new therapies have been proposed. This paper will revolve around cell therapy. The common methods used in clinical treatment of diseases are surgery, chemical drugs, ion exposure, plant drugs. The development of modern medical theory and technology gradually introduced cell therapy into the clinic. Cell therapy is a treatment with functional cells as the main body. Cell therapy can be used as an independent treatment or combined with the above-mentioned routine treatment. In recent years, cell therapy has shown increasing application value in the treatment of genetic diseases, cancer, tissue injury, diabetes and other diseases, and details current cell therapy and prospects.
The Present and Future Trend of Monoclonal Antibody
Authors: Qian Muyan
Published: January 2024

Over the past three decades, the realm of monoclonal antibodies has witnessed a remarkable metamorphosis. Initially conceptualized and utilized as mere scientific instruments, these antibodies have now evolved into potent therapeutic agents, revolutionizing the landscape of modern medicine. The United States and Europe, being at the forefront of medical advancements, have embraced this transformation, with nearly 30 therapeutic monoclonal antibodies currently available in their markets. These antibodies, tailored to target specific antigens, offer a precision in treatment that was previously unattainable. This review delves into the intricate journey of monoclonal antibodies, tracing their origins, their initial applications in research, and their eventual rise as therapeutic giants. Furthermore, the paper sheds light on the challenges faced in their development, the breakthroughs that propelled their success, and the potential future innovations that could further harness their capabilities. As standing on the cusp of medical breakthroughs, understanding the past and potential future trajectories of monoclonal antibodies becomes paramount.
Research Progress on Pathogenesis of Lung Cancer and Prevention Discussion
Authors: Wang Xiaofan
Published: January 2024

Lung cancer is one of the most common malignant tumors, it has brought a great threat to human health. In recent years, the mortality and incidence of lung cancer have ranked first among cancers, the characteristics of lung cancer, such as being difficulty diagnosed in the earlier stage; rapidly developing condition, difficult treatment, and high rate of morbidity, which has taken harm to people's normal living quality, Lung cancer is related to internal factor-human body, and external factor-environment and human factors. In this paper, smoking, diet and nutrition, regional distribution, indoor and outdoor air pollution, gender, occupational exposure, lung-related medical history, genetics, gene mutation and other factors related to the occurrence of lung cancer are reviewed in the latest domestic research. The prevention actions to be done by individuals like changing lifestyle, sufficient physical exercises, emotional control, physical examination in certain periods, and sleeping improvement are reviewed; The prevention actions to be done by the government like improving environment, carbon emission control, and air pollution improvement are discussed. Both individuals and society should pay attention to these preventative actions, and make sure these actions are followed up and reached, so the serious impact from lung cancer can be greatly reduced. People’s normal living quality can be greatly improved.
How immune system impact the nervous system
Authors: Huang Bohan
Published: January 2024

Immune system and nervous system are both important. Adaptive immune system and innate immune system are two categories of the immune system. Both types of system have a lot of organs that has different types of function. Both the CNS and the PNS share this characteristic. The nervous system disorders have some relationship with the immune cells being too activated. The T-cells, B-cells, macrophages, and glial cells will become to activate and accidently kill some cells in the nervous systems to cause the diseases. However, these types of disorders will have a varying cause and the scientists have to spend more studying on that. Autoimmune encephalitis (AE), Acute disseminated encephalomyelitis (ADEM) and Multiple sclerosis (MS) are both common disease with a huge prevalence around the world. This research paper has found out the treatment and pathogenesis of these diseases. The main cause of these types of diseases are the disorders of immune cells.
The Application of Brain-Spine Interface on Spinal Cord Injury
Authors: Qin Haoran
Published: January 2024

Spinal cord injuries (SCI) hold considerable significance owing to their profound and often irreversible effects on crucial neurological functions, resulting in a substantial reduction in overall quality of life for those affected. The essay explores the transformative potential of the brain-spine interface in the context of SCI rehabilitation. It delves into the cutting-edge technology that enables direct communication between the brain and the spinal cord, bypassing damaged neural pathways. The abstract highlights the profound impact of this innovation on individuals with SCI, offering the hope of restoring lost motor and sensory functions. Additionally, it touches upon the challenges and ethical considerations associated with its application. Ultimately, the essay sheds light on the brain-spine interface as a groundbreaking solution that holds promise for enhancing the quality of life for those with spinal cord injuries.
Analysis and Comparison of Cosmic Distance-Measuring Scenarios
Authors: Liu Yuqi
Published: January 2024

As a matter of fact, astronomical research relies heavily on Earth-star distance measurement. With this in mind, it is crucial to develop accurate detection approaches with high precision facility. On this basis, this study introduced four commonly used measuring methods. The trigonometric parallax, in which triangulation is used to calculate the distance. The spectroscopic parallax, determining the distance of stars through spectrum analysis, and the comparison between a star’s luminosity and apparent brightness. The variable stars measurement, in which the variable stars are set as standard distances to determine nearby stars’ distance. The main-sequence fitting method uses theoretical models to determine the distance of stars in star clusters. While the first two methods are more likely to be precise, the last two are able to measure the distance of further stars. To gain more accuracy, more research about the cosmic background and theoretical models needs to be done. Overall, these results shed light on guiding further exploration of distance measurement.
Nonlinear vibration study of cylindrical shells
Authors: Zhang Jinyan
Published: January 2024

Shells are common structures and models in our life. With the continuous development of research on various types of shells, shells have been very widely used in daily life, industrial buildings, aerospace, space technology and other fields. In this paper, firstly, the expressions of each energy variant of the shell under the joint action of elasticity and piezoelectric layer electric field are given, and the physical model is established based on Hamilton's principle. Secondly, a nonlinear multi-degree-of-freedom dynamics model of the vibration of the cylindrical shell is developed by considering the asymmetric modes of the shell. Considering the boundary conditions and separating the displacement function from the independent time variables, the specific expressions of the stiffness matrix are calculated according to the energy variations as well as the internal forces and moments, and the generalized coordinate vectors are solved and analyzed by giving specific examples.
Intelligent Fire Resistance Testing and Calculation of Precast Modular House by Computer Numerical Simulation
Authors: Zhao Qian , Qi Yuliang , Shi Chuqi , Huang Keke , Huang Zhuchun
Published: January 2024

Through the fire resistance tests of fourteen components and one full-scale flat-packed modular house, the fire resistance limits of both steel components under standard fire curve and modular house entirety under real fire were studied. Test results showed that the fire safety could be guaranteed for applying light steel modular houses in low-rise buildings. In addition to structural fire protection design, fire performance simulation should also be combined with the measures of smoke alarm, spray, smoke diffusion simulation, evacuation simulation, fuel control and rescue response to ensure the fire safety. The research results of this paper can provide references for fire protection design of light steel modular houses.
Preface: 2nd International Conference on Theoretical Physics, Computers and Electronic Engineering (TPCEE 2023)
Authors: Kennan Malcolm , Yue Qianjiang
Published: January 2024

This volume contains papers accepted by the 2023 2nd International Conference on Theoretical Physics, Computers and Electronic Engineering (TPCEE 2023), which was held during October 14-15, 2023 in Toronto, Canada. TPCEE 2023 brought together innovative scholars and industry experts to jointly hold a forum. The main objective of the conference is to promote the research and development activities of theoretical physics, astrophysics, quantum physics, computer engineering, information technology, and electronic engineering. The other objective is to promote the exchange of scientific information among researchers, developers, engineers, students, and practitioners around the world.

Over 100 participants from many countries attended this conference, which included 4 keynote speeches and 24 oral presentations on different aspects in 4 sections. The cutting-edge research works were presented by such renowned keynote speakers. The TPCEE 2023 was a success where all the participants gathered on this platform and share experiences and research findings in their respective fields.

Organizing Committees of TPCEE 2023

Toronto, Canada
Study on pathologic mechanism and treatment of hypertension
Authors: Ding Pengyuan
Published: January 2024

Hypertension is a cardinal contributor to the global burden of disease due to its widespread prevalence and its insidious ability to instigate life-threatening complications such as stroke, cardiac failure, and renal injury disorders. This discourse reviewed the key drivers of hypertension pathogenesis, emphasizing the role of the renal system, particularly the interplay of angiotensin II and renal impairment. Moreover, hypertension's complex and multivalent management strategies were overviewed, illustrating the salience of lifestyle modifications, a panoply of pharmacological interventions, synergistic combination therapies, and the innovative approach of personalized medicine. Nevertheless, challenges such as medication adherence and balancing side effects remain, alongside the requirement for persistent medical oversight reflective of hypertension’s chronic nature. As lethal complications ink the finality of hypertension’s narrative, prompt identification and treatment are paramount. This comprehensive account concludes with an urge to further dissect this intricate condition and refine management strategies, propelling us towards a future with more efficacious hypertension control and diminished complication rates.
Specific Information about Cardiac Neurosis and Treatment and Prevention
Authors: Wang YuFei
Published: January 2024

Heart disease has plagued mankind since the earliest times. There are some common heart conditions like coronary heart disease, congenital heart disease, hypertensive heart disease and so on. These heart sicknesses afflict people of all ages. There is a people around who have heart disease, but don't hear about it often compared to others. She thought it was just a faster heartbeat until she was diagnosed, and then a variety of symptoms occurred that were more severe before she was diagnosed with cardiac neurosis. This disease can also occur at different ages, many behaviors and different other sicknesses have an impact on it as well. How do we recognize these symptoms as indicative of cardiac neurosis, and what can we do to prevent and treat the disease once it has been diagnosed? With these questions I want to learn more about this disease and let more people know this disease.
The Prevalence of Depression Among Medical Staff During The COVID-19 Pandemic
Authors: Cao Xinyu
Published: January 2024

Background: Medical professionals' psychological health has been significantly damaged by the COVID-19 pandemic, with nurses being a particularly susceptible group. The purpose of this study is to assess the prevalence of depression among healthcare professionals during the pandemic, investigate risk variables, and provide suitable supportive treatments. Objective: This research combines data from 11 studies involving 424 healthcare professionals, including doctors, nurses, and others. The prevalence of depression and associated variables in these professions during the COVID-19 outbreak are examined. Methods: Data were gathered from many study initiatives that covered the 2020 to 2023 time period. In these research, the Impact of Events Scale Revised (IES-R), the Patient Health Questionnaire (PHQ-9), and the Perceived Stress Scale (PSS-10) were used to assess post-traumatic stress, depression, and stress levels. The study looked into demographic variables, individuals' mental health backgrounds, and aspects connected to their jobs in the healthcare industry. Results: COVID-19 pandemic led to 19% severe depression symptoms in healthcare professionals, with females, younger workers, and nursing professionals more susceptible. Social support strongly influences the results of mental health. Conclusion: Medical staff's mental health has been severely impacted by the COVID-19 epidemic, with nurses experiencing increased levels of despair and anxiety. Gender disparities in mental health outcomes highlight the need for targeted support for female healthcare workers. Improving working conditions and strengthening social support networks are essential steps in addressing these mental health challenges. To fully understand the long-term consequences on the mental health of healthcare workers, taking into consideration cultural and socioeconomic factors, further longitudinal study is needed. Offering culturally sensitive mental health support is pivotal for the welfare of healthcare workers.
Application of Memory Natural Killer Cells in HIV Vaccine
Authors: Wu Wenting
Published: January 2024

Human immunodeficiency virus (HIV) is a formidable infection targeting the intricate defense mechanisms of the human body, primarily focusing its assault on the vital white blood cells known as CD4 cells. HIV impairs these CD4 cells, reducing resistance to opportunistic infections. In 2022, 630,000 people died from HIV-related causes globally due to the lack of preventative vaccines and effective treatment. The pursuit of an effective HIV vaccine remains a critical endeavor in global health, necessitating innovative strategies that can elicit robust and durable immune responses. Natural killer (NK) cells, renowned for their swift and inherent cytotoxic prowess, constitute a critical element of innate immunity, typically thought to be deficient in memory abilities. Fascinatingly, NK cells have now become the focal point of scientific research due to emerging evidence suggesting the presence of memory-like characteristics within their functional repertoire. Through a comprehensive exploration of NK cell subpopulations and the strategic application of cytokines or other stimuli to induce the development of memory-generating NK cell subpopulations, the potential for enhancing the efficacy of HIV vaccines emerges. This approach holds promise in bolstering the creation of adaptive immunity and advancing the quest for effective HIV immunization strategies. The study offers valuable insights into the potential of NK memory cells as a viable component of future HIV vaccine regimens, suggesting avenues for further research and development in the quest to mitigate the global burden of HIV.
Synthesis of New Biodegradable Beauty Mask with Sodium Alginate and Agar
Authors: Jian Peishan , Li Wen , Wei Lijia
Published: January 2024

Nowadays, with the improvement of living standards, the consciousness of people over their skin status and hope for finding ways to pursue its perfect condition has become one of the most concerned topics. In this investigation, a wide range of sodium alginate, agar, and glycerol blends was rationed to find the most suitable mixture to produce beauty masks. The blend of 3 g pure sodium alginate, 1.25 g agar, and 250 mL of 4% (w/v) glycerol was used. The film without cross-linking could withstand twice as much weight compared to the film with CaCl2, making it 13 times higher when comparing its stress. The water content is higher for the film without CaCl2. When the two film was tested for glycerol and alcohol absorbance, sodium alginate with no cross-linking absorbance is preferred when testing in glycerol since it is less soluble. However, when testing with alcohol, the film with CaCl2 is less soluble, thus preferred. The above qualities in which the film sample with CaCl2 possess therefore enables it as a perfect paste for a beauty mask, being tensile, high absorbance of serum to provide a holistic care.
Second-hand sailboat price assessment based on ANOVA
Authors: Zhu Chengxuan , Fang Zihan , Zheng Jiaying
Published: January 2024

As a luxury, the price of second-hand sailing will vary with the changes of years and markets, and its price may be affected by many factors, such as regional differences, various characteristics of sailing and the year of production of sailing. In order to determine the dominant factors affecting sailing prices and explain the changes of sailing prices, Spearman correlation analysis is used. Multivariate linear regression model is established to analyze and determine the weight of the indicators affecting the sailing, and finally get a formula to explain the sailing price. Based on the price model of sailing using ridge regression, ANOVA was used to further determine the effect of regions on different variants of sailing.Considering the consistent effects of different regions on the same variable, a two-way ANOVA was used to identify the inconsistent effects of different regions on different navigation variables.Finally, according to the results of variance analysis, it was found that the price of second-hand sailing varied significantly in different regions, and through two-way variance analysis, there was no consistency between different sailing variants.
Application of Cauchy’s Residue Theorem in Several Improper Integrals
Authors: Zhang Hongyi
Published: January 2024

Calculating definite integrals in complex functions requires the Cauchy's residue theorem, which is a key concept in the complex variables. It is based on several ideas, including the isolated singular points theory, the Laurent theorem, and the Cauchy integral theorem. Nevertheless, it is highly challenging to calculate closed curves using the conventional integrals method since numerous formulas must be substituted. The singular points must all be isolated in the case of a holomorphic function  that belongs to an enclosing contour  and  is positively oriented, at which time the contour integral  can be used to resolve the issue. Additionally, the problem can be solved by using visual aids to help people understand them. By doing so, the notion of solving the problem will be made clearer and some calculating steps will be cut short. This study exhibits the residue theorem's potent efficiency in computing improper integrals and other difficult problems.
Revitalizing the Population of Tachypleus tridentatus: A Comprehensive Study Tachypleus tridentatus Conservation in China
Authors: Qiao Ruiting
Published: January 2024

Tachypleus tridentatus is an ancient marine arthropod. Currently, the population of Tachypleus tridentatus has decreased rapidly, in 2019, the IUCN Red List officially updated the endangered status of Tachypleus tridentatus to Endangered (EN), indicating a global decline in the resources of this species. However, the lack of data, such as population baseline data, acts as a barrier for this nearshore habitat and medically important species. The results of this paper suggest that the main causes of the decline in the population of the Tachypleus tridentatus darter are overfishing and habitat destruction. In addition, the discussion focuses on three techniques presently employed in China to revive the population of Tachypleus tridentatus, including fisheries enhancement, habitat designation for conservation, and educational programs. The study also examines the advantages and disadvantages of conservation methods implemented in China, and while certain methods, such as moratoriums on aquaculture, show significant advantages, others, such as the establishment of protected habitats, have limitations due to incomplete findings. These methods provide a solid foundation for the conservation of the Tachypleus tridentatus, and also point to possible future directions, such as the implementation of polyculture. However, there is a need to improve the efficiency of existing methods through further development and additional data collection studies. To address the acknowledged limitations and gaps in this study, additional exploration and discourse are imperative to advance the preservation of Tachypleus tridentatus.
A study of fixed-sun mirror field alignment based on mathematical methods
Authors: Wang Haoyu , Jiang Lewei , Xie Da
Published: January 2024

Different shapes of heliostat mirrors and different arrangements of mirror fields are important factors affecting the thermal power output of tower-type solar power plants. In this paper, for a regional heliostat mirror field, a coordinate system of heliostat mirror field is established, through which the incident vector of sunlight, normal vector of heliostat mirror plane is calculated, and the mirror coordinate system is transformed to calculate the optical cosine efficiency, and the discrete lattice point method and ray-tracing method are used to calculate the shadow blocking efficiency and truncation efficiency. The average annual optical efficiency of the mirror field in this area is 0.609784988, the average annual thermal power output is 37.27373787 MW, and the average annual thermal power output per unit area is 0.593341895 kW/m2, which can be used as a reference basis for the arrangement of the heliostat mirror field in this area.
Unveiling Definite and Indefinite Integrals Through Flexibly Using Different Formulas
Authors: Jin Zhiyuan
Published: January 2024

One of the most powerful branches of mathematics is calculus. It is closely related with the study of changing rate and the quantity accumulation, which provides a framework for understanding and analyzing complex, continuous processes. Integral calculus and differential calculus are two main branches in calculus. Differential calculus focuses on the concept of derivatives, which represent the rate at which a quantity changes related to another variable. Derivatives are fundamental in understanding and describing processes that involve instantaneous rates of change, such as velocity, acceleration, and growth rates. By calculating derivatives, one can determine critical points, identify trends, and solve optimization problems. In contrast, integral calculus focuses on the notion of integrals, which signify the gathering of quantities within a given interval. Integrals allow people to find areas, volumes, and total amounts by summing infinitesimally small contributions. They are especially useful for solving problems involving accumulation, such as finding the area under a curve, determining total distance traveled, and calculating the net change in a quantity over a given interval.
The study of structure and function of human cell
Authors: Hu Run
Published: January 2024

Biological structure and function is the core field of life sciences, covering the complex organizational structure and various functions it undertakes. Cells are a very important structure and the basic unit of life activities, which means that without cells, all life activities cannot continue. So on this basis, we studied the function and structure of cells. The findings suggest that each organelle has a specific functional structure and that changes or mutations in the structure of these proteins or the arrangement of membrane proteins on the surface can lead to the development of related diseases, such as abnormalities in the Golgi apparatus leading to Alzheimer's disease Abnormalities in mitochondria can lead to lesions in muscles or the nervous system or even cancer, and mutations in the nucleus can cause babies to be born with various defects. Cells are the unit of life activities. Once the organelles are abnormal, different diseases will occur.