bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Enantioselective Sulfur‐Michael Addition of Thioacetic Acid to Nitroalkenes Catalyzed by Bifunctional Amine‐Thiourea Catalysts.
Authors: Wang Renchao , Xu Jiaxi
Published: April 2015

Asymmetric sulfur‐Michael addition of Ac—SH to nitroalkenes is achieved in the presence of a leucine‐derived bifunctional thiourea catalyst.
ChemInform Abstract: The First Bidirectional [4 + 2] Cycloadditions of Benzo[1,2:4,5]dicyclobutenes: Synthesis of Benzo[1,2‐f:4,5‐f′]diisoindole‐1,3,7,9‐tetraones.
Authors: Abdelhamid Ismail Abdelshafy , Butenschoen Holger
Published: April 2015

The synthesis of the title compounds (III) consists of an electrocyclic ring opening of substrates (I), [4 + 2] cycloaddition with maleimide (II), spontaneous elimination of methanol, and subsequent oxidation with DDQ.
ChemInform Abstract: Rh(III)‐Catalyzed Hydrative Cyclization of 1,6‐Allenynes: Synthesis of Six‐Membered Nitrogen and Oxygen Heterocycles.
Authors: Quan Shasha , Wang Yuanyuan , Zheng Kewen , Tong Xiaofeng
Published: April 2015

The reaction proceeds in rarely reported fashion of 6‐endo cyclization and affords dihydropiperidines and dihydropyrans.
ChemInform Abstract: Stereocontrolled Synthesis of Benzo[k]fluoranthenes — An Unexpected Isomerization Mediated by Rhodacyclopentadiene.
Authors: Xu Shengjie , Chen Kejuan , Chen Hui , Yao Jiannian , Zhu Xiaozhang
Published: April 2015

Herein, a RhIII‐catalyzed stereocontrolled synthesis of benzo[k]fluoranthenes is reported.
ChemInform Abstract: Palladium Catalyzed Intramolecular Vinylselenation and Vinylthiolation of Allenes
Authors: Kambe Nobuaki , Fujiwara Shin‐ichi , Tsuda Susumu , Okuyama Maiko , Iwasaki Takanori , Kuniyasu Hitoshi
Published: April 2015

furnishing pyridin‐2‐one (II) or lactams (IV)
ChemInform Abstract: Development of an Azanoradamantane‐Type Nitroxyl Radical Catalyst for Class‐Selective Oxidation of Alcohols.
Authors: Doi Ryusuke , Shibuya Masatoshi , Murayama Tsukasa , Yamamoto Yoshihiko , Iwabuchi Yoshiharu
Published: April 2015

The title catalyst is prepared on gram scale in an eight‐step sequence and affords superior results to TEMPO and its 1‐methylazaadamantane analogue, not only for the class‐selective oxidation of primary alcohols to aldehydes in the presence of a secondary alcohol, but also for the selective one‐pot oxidation to carboxylic acids as well as for oxidative lactonization.
ChemInform Abstract: Copper‐Catalyzed Selective Hydroamination Reactions of Alkynes.
Authors: Shi Shi‐Liang , Buchwald Stephen L.
Published: April 2015

This is a versatile method for the hydroamination and reductive hydroamination of alkynes yielding enamines and amines respectively.
ChemInform Abstract: Copper‐Catalyzed Oxidative Homo‐ and Cross‐Coupling of Grignard Reagents Using Diaziridinone.
Authors: Zhu Yingguang , Xiong Tao , Han Wenyong , Shi Yian
Published: April 2015

The cross‐coupling is applied to the synthesis of aryl‐aryl, aryl‐alkynyl, and alkynyl‐alkyl cross‐coupling products starting either from two Grignard reagents, or from an alkyne which is transformed into the corresponding Grignard reagent in situ.
ChemInform Abstract: Quinone Diazides for Olefin Functionalization.
Authors: Dao Hai T. , Baran Phil S.
Published: April 2015

While cyclooctene undergoes cyclopropanation, terminal alkenes give the corresponding arylated alkanes after selective cleavage of intermediate cyclopropane derivatives followed by scavenging with nucleophiles.
ChemInform Abstract: Palladium‐Catalyzed Stereoretentive Olefination of Unactivated C(sp3)—H Bonds with Vinyl Iodides at Room Temperature: Synthesis of β‐Vinyl α‐Amino Acids.
Authors: Wang Bo , Lu Chengxi , Zhang Shu‐Yu , He Gang , Nack William A. , Chen Gong
Published: April 2015

A new method for the Pd‐catalyzed N‐quinolyl‐directed olefination of phthaloyl alanine (I) with vinyl iodides is reported.
ChemInform Abstract: Improving Catalyst Activity in Secondary Amine Catalyzed Transformations.
Authors: Brazier John B. , Gibbs Timothy J. K. , Rowley Julian H. , Samulis Leopold , Yau Sze Chak , Kennedy Alan R. , Platts James A. , Tomkinson Nicholas C. O.
Published: April 2015

The applied catalyst is readily prepared in one step.
ChemInform Abstract: Copper/Palladium‐Cocatalyzed Aerobic Synthesis of Bisaryl Ketones from Olefins via C—C Double Bonds Cleavage.
Authors: Gu Lijun , Liu Jiyan , Zhang Hongtao
Published: April 2015

A novel palladium/copper‐catalyzed aerobic synthesis of bisaryl ketones from 1,2‐diarylalkenes via C—C double bonds cleavage is described.
ChemInform Abstract: An Efficient Approach to the Synthesis of Hydrazinyl Pseudo‐Peptides.
Authors: Fathi Vaezeh , Ramezanpour Sorour , Balalaie Saeed , Rominger Frank , Reza Bijanzadeh Hamid
Published: April 2015

The novel hydrazinyl pseudo‐peptides, obtained by an Ugi four‐component reaction, possess high potential for H‐bonding.
ChemInform Abstract: Synthesis of Vinyl‐ and Aryl‐Acyl Sulfonimidamides Through Pd‐Catalyzed Carbonylation Using Mo(CO)6 as ex situ CO Source.
Authors: Wakchaure Prasad B. , Borhade Sanjay R. , Sandstroem Anja , Arvidsson Per I.
Published: April 2015

A Pd(0)‐catalyzed process for the amidocarboxylation of sulfonimidamide nucleophiles with Mo(CO)6 as CO‐source and vinyl halides and triflates as well as aryl triflates is developed.
ChemInform Abstract: Asymmetric Synthesis of Allylic Sulfonic Acids: Enantio‐ and Regioselective Iridium‐Catalyzed Allylations of Na2SO3.
Authors: Liu Wei , Zhao Xiao‐ming , Zhang Hong‐bo , Zhang Liang , Zhao Ming‐zhu
Published: April 2015

Various alkyl, aryl and hetaryl substituted allyl carbonates serve as substrates.
ChemInform Abstract: Room‐Temperature Suzuki—Miyaura Reaction Catalyzed by Palladium Nanoparticles in Lactate‐Anion Ionic Liquid.
Authors: Wang Furong , Tang Sisi , Ma Hao , Wang Lefu , Li Xuehui , Yin Biaolin
Published: April 2015

Palladium nanoparticles stabilized in an lactate‐anion ionic liquid are shown to be an efficient catalyst for the Suzuki—Miyaura coupling reaction at room temperature.
ChemInform Abstract: Efficient Microwave Method for the Oxidative Coupling of Phenols.
Authors: Grant‐Overton Sharday , Buss Joshua A. , Smith Eva H. , Gutierrez Elisa G. , Moorhead Eric J. , Lin Vivian S. , Wenzel Anna G.
Published: April 2015

An efficient protocol for the oxidative coupling of phenols and naphthols is developed and compared with other oxidative coupling methodologies.
ChemInform Abstract: Catalytic Enantioselective Synthesis of Indanes by a Cation‐Directed 5‐endo‐Trig Cyclization.
Authors: Johnston Craig P. , Kothari Abhishek , Sergeieva Tetiana , Okovytyy Sergiy I. , Jackson Kelvin E. , Paton Robert S. , Smith Martin D.
Published: April 2015

The indanes are enantioselectively obtained as single diastereoisomers by a kinetically unfavorable 5‐endo‐trig cyclization, a rare mode of reaction.
ChemInform Abstract: Direct C—H Iodination of 1,3‐Azoles Catalyzed by CuBr2.
Authors: Zhao Xia , Ding Fang , Li Jingyu , Lu Kui , Lu Xiaoyu , Wang Bin , Yu Peng
Published: April 2015

The copper‐catalyzed metalation/iodination proceeds under relatively weak basic conditions using a combination of tBuOLi and phenanthroline.
ChemInform Abstract: Thermal [2 + 2]‐Cycloadditions of Diphenylketene with Aryl‐ and Hetaryl‐Substituted Thioketones
Authors: Heimgartner Heinz , Mloston Grzegorz , Urbaniak Katarzyna , Szychowska Anna , Linden Anthony
Published: April 2015

as an efficient route to corresponding tetraarylthietan‐2‐ones (III)
ChemInform Abstract: Ammonium‐Salt‐Tagged IMesAuCl Complexes and Their Application in Gold‐Catalyzed Cycloisomerization Reactions in Water.
Authors: Belger Katrin , Krause Norbert
Published: April 2015

Ammonium‐tagged IMesAuCl‐complexes (I) are designed and applied as water soluble NHC‐gold catalysts for the cycloisomerization of allenes (II) to dihydrofurans and alkynediols (IV) and (VI) to spirocyclic products (V) and (VII).
ChemInform Abstract: Synthesis of α‐Halobutenolides Using the Nucleophilicity of Magnesium Alkylidene Carbenoids.
Authors: Satoh Tsuyoshi , Kimura Tsutomu , Fukuda Kazuki , Kashiwamura Gaku
Published: April 2015

A novel three‐step method for the synthesis of title compound (VI) is developed starting from readily available materials.
ChemInform Abstract: Direct Arylation of Benzo[b]furan and Other Benzo‐Fused Heterocycles.
Authors: Dao‐Huy Toan , Haider Maximilian , Glatz Fabian , Schnuerch Michael , Mihovilovic Marko D.
Published: April 2015

The novel protocol allows the regioselective direct arylation of benzo‐fused heterocycles with arylbromides to produce the corresponding 2‐substituted products in moderate yields.
ChemInform Abstract: [2 +2 + 2] Cycloaddition of Sulfanylbenzene‐Tethered Diynes with Alkynes for the Synthesis of Multi‐Substituted Dibenzothiophene Derivatives.
Authors: Shibata Takanori , Tahara Yu‐ki , Matsubara Riku
Published: April 2015

A Rh‐catalyzed [2 + 2 + 2] cycloaddition of sulfanylbenzene‐ and sulfonylbenzene‐tethered 1,6‐diynes with various alkynes is presented.
ChemInform Abstract: Efficient Synthesis of cis‐3‐Substituted Prolines by Bidentate‐Assisted Palladium Catalysis.
Authors: Feng Ruokun , Wang Binjie , Liu Yue , Liu Zhanxiang , Zhang Yuhong
Published: April 2015

The Pd‐catalyzed oxidative coupling of chiral prolinamide (I) having a N‐quinolinyl directing group with aryl iodides is examined to yield C‐3 substituted products (III) in excellent cis‐selectivity.
ChemInform Abstract: Copper‐Catalyzed Three‐Component Tandem Reactions for the Synthesis of β‐Carboalkoxy‐γ‐lactams.
Authors: Li Zhengning , Feng Yunyun , Li Zengchang , Jiang Lan
Published: April 2015

The title compounds are prepared with high trans‐selectivity from aldimines (I) and (IV) and maleates (II) and (VI) in the presence of polymethylhydrosiloxane (PMHS).
ChemInform Abstract: Synthesis of Highly Functionalized Polycyclic Quinoxaline Derivatives Using Visible‐Light Photoredox Catalysis.
Authors: He Zhi , Bae Minwoo , Wu Jie , Jamison Timothy F.
Published: April 2015

The phenyl iodine dicarboxylate substrates (II) and (XI) can be easily prepared from the corresponding acids and PhI(OAc)2 by ligand exchange and used in the photoreaction without further purification.
ChemInform Abstract: Novel Synthesis of 5‐Methyl‐5,10‐dihydroindolo[3,2‐b]indoles by Pd‐Catalyzed C—C and Two‐Fold C—N Coupling Reactions.
Authors: Hung Tran Quang , Hancker Soeren , Villinger Alexander , Lochbrunner Stefan , Dang Tuan Thanh , Friedrich Aleksej , Breitsprecher Wolfgang , Langer Peter
Published: April 2015

The UV‐VIS and fluorescence properties of some products are investigated.
ChemInform Abstract: Acid‐ and Metal‐Free Synthesis of Annulated Pyrroles in a Deep Eutectic Solvent.
Authors: Rokade Sunil M. , Garande Ashok M. , Ahmad Nazim A. A. , Bhate Prakash M.
Published: April 2015

An environmentally friendly, one‐pot synthesis of optically pure annulated pyrroles [cf.
ChemInform Abstract: One‐Pot Synthesis of Triazoles from Organic Halides and Alkynes in Nonionic Nanomicelles at Room Temperature.
Authors: Xie Aming , Xu Xiao , Li Junjian , Wang Boliang , Dong Wei
Published: April 2015

A micelle catalytic process for the synthesis of a wide range of triazoles from halides, alkynes, and sodium azide in water as solvent is developed.
ChemInform Abstract: Organocatalytic Domino Michael‐Heterocyclization Reaction of α,β‐Unsaturated Aldehydes and α‐Cyano Ketones: Synthesis of Enantioenriched 4,5,6‐Trisubstituted 3,4‐Dihydropyranones.
Authors: Guevara‐Pulido James O. , Andres Jose M. , Pedrosa Rafael
Published: April 2015

The reaction of α‐cyano ketones with aldehydes (II) in the presence of chiral diphenylsilylprolinol catalyst gives enantioenriched hemiacetals, which are further oxidized to produce dihydropyranones.
ChemInform Abstract: An Expeditious Coumarin Synthesis via a “Pseudocycloaddition” Between Salicylaldehydes and Ketene.
Authors: Chandrasekhar Sosale , Kumar Honnaiah Vijay
Published: April 2015

The introduced procedure represents a very mild variant of the historic Perkin synthesis of coumarin.
ChemInform Abstract: Indium‐Catalyzed Intramolecular Hydroarylation of Aryl Propargyl Ethers.
Authors: Alonso‐Maranon Lorena , Martinez M. Montserrat , Sarandeses Luis A. , Sestelo Jose Perez
Published: April 2015

The presented reaction selectively delivers the 6‐endo product, namely 2H‐chromenes, and succeeds with substrates equipped with terminal or internal alkynes, tolerates various electron‐rich and electron‐deficient substituents on the benzene as well as the alkyne moiety.
ChemInform Abstract: Iron(II,III) Oxide Nanoparticle‐Catalyzed Selective Synthesis of Unknown Dihydropyrano[c]chromenes under Green Conditions.
Authors: Khodabakhshi Saeed , Karami Bahador , Baghernejad Mojtaba
Published: April 2015

The title compounds (IV) are obtained by one‐pot three‐component condensation between 4‐hydroxycoumarin (I), various aryl glyoxals (II), and malononitrile (III), using magnetically recyclable Fe3O4 nanoparticles as catalyst.
ChemInform Abstract: Enantioselective Construction of Functionalized Thiopyrano‐Indole Annulated Heterocycles via a Formal Thio [3 + 3]‐Cyclization.
Authors: Chen Xiang , Qi Zheng‐Hang , Zhang Shao‐Yun , Kong Ling‐Pei , Wang Yong , Wang Xing‐Wang
Published: April 2015

A series of chiral thiopyrano‐indoles (III) and (V) is readily obtained by an enantioselective cyclization of indoline‐2‐thiones (I) with dinitriles (II) and (IV).
ChemInform Abstract: Thioacetamide as an Ammonium Source for Multicomponent Synthesis of Pyridines from Aldehydes and Electron‐Deficient Enamines or Alkynes.
Authors: Wan Jie‐Ping , Zhou Youyi , Jiang Kezhi , Ye Hongyan
Published: April 2015

The multicomponent reaction provides a one‐step access to 3,4,5‐trisubstituted pyridines and succeeds using aryl aldehydes, but fails with alkyl aldehydes.
ChemInform Abstract: Metal‐Free‐Mediated Oxidation Aromatization of 1,4‐Dihydropyridines to Pyridines Using Visible Light and Air.
Authors: Wei Xiaojing , Wang Lin , Jia Wenliang , Du Shaofu , Wu Lizhu , Liu Qiang
Published: April 2015

12 Pyridine derivatives of type (II) are prepared from the corresponding 1,4‐dihydropyridines by aerobic aromatization photosensitized by the organic dye TBA‐eosin Y.
ChemInform Abstract: Direct Arylation of Substituted Pyridines with Arylboronic Acids Catalyzed by Iron(II) Oxalate.
Authors: Huang Yibo , Guan Dan , Wang Liang
Published: April 2015

Optimum reaction conditions are examined for the arylation of substituted pyridines with arylboronic acids in the presence of iron(II) oxalate and potassium peroxodisulfate.
ChemInform Abstract: Catalytic Oxidative Cyclization of 2′‐Arylbenzaldehyde Oxime Ethers under Photoinduced Electron Transfer Conditions.
Authors: Hofstra Julie L. , Grassbaugh Brittany R. , Tran Quan M. , Armada Nicholas R. , de Lijser H. J. Peter
Published: April 2015

The photocyclization of oxime ethers in the presence of 9,10‐dicyanoanthracene as the sensitizer affords phenanthridines without any nitrile byproducts.
ChemInform Abstract: Domino Four‐Component Synthesis of Novel Cycloocta[b]pyridines.
Authors: Maharani Seeni , Kumar Raju Ranjith
Published: April 2015

A domino Knoevenagel condensation/Michael addition/nucleophilic addition/cyclization/aromatization sequence allows the synthesis of cyclooctapyridines in a single transformation.
ChemInform Abstract: Palladium‐Mediated Intramolecular Biaryl Coupling Reaction: Convenient Preparation of Furoquinolinone Derivatives.
Authors: Abe Hitoshi , Kamimura Mayu , Komatsu Yoshinori , Horino Yoshikazu
Published: April 2015

N‐S substituted furo[2,3‐c]‐ or furo[3,2‐c]quinoline derivatives are obtained by palladium‐mediated intramolecular biaryl coupling of appropriate furoylanilides.
ChemInform Abstract: Dithienoquinazolines — A Convenient Synthesis by the Oxidative Photocyclization of 4,5‐Dithienyl‐Substituted Pyrimidines and Their Photophysical Properties.
Authors: Verbitskiy Egor V. , Slepukhin Pavel A. , Valova Marina S. , Cheprakova Ekaterina M. , Schepochkin Akesandr V. , Rusinov Gennady L. , Charushin Valery N.
Published: April 2015

The oxidative photocyclization of 4,4‐dithienyl substituted pyrimidines provides a convenient access to dithienoquinazolines, including brominated derivatives such as (VI) and (VIII).
ChemInform Abstract: Synthesis of Novel 2‐(Methylthio)benzo[g][1,2,4]triazolo[1,5‐a]quinazolin‐ 5‐(4H)‐one and Its Derivatives.
Authors: Al‐Salahi Rashad A. , Marzouk Mohamed S. , Ghabbour Hazem A. , Kun Fun H.
Published: April 2015

Cyclocondensation of 3‐hydrazinoyl‐2‐naphthoic acid (I) with N‐cyanoimidodithiocarbonate (II) gives the target triazoloquinazolinone (III), which provides access to a variety of derivatives upon chemical transformations of its lactam or methylthio groups.
ChemInform Abstract: Catalytic Systems Containing p‐Toluenesulfonic Acid Monohydrate Catalyzed the Synthesis of Triazoloquinazolinone and Benzimidazoquinazolinone Derivatives.
Authors: Mousavi Mir Rasul , Maghsoodlou Malek Taher
Published: April 2015

A novel, simple, convenient, and efficient synthesis of the title compounds (IV) and (VII) via a metal‐free, one‐pot three component reaction procedure.
ChemInform Abstract: A General Metal‐Assisted Synthesis of α‐Halo Oxime Ethers from Nitronates and Nitro Compounds.
Authors: Sukhorukov Alexey Yu. , Kapatsyna Maria A. , Yi Tammy Lim Ting , Park Hyeong Ryool , Naumovich Yana A. , Zhmurov Petr A. , Khomutova Yulia A. , Ioffe Sema L. , Tartakovsky Vladimir A.
Published: April 2015

Bis(oxy)enamines (I) and (XII) undergo an unprecedented reaction with cobalt(II) halides to produce a variety of cyclic and acyclic ethers of α‐halo oximes including previously unavailable trimethylsilyl ethers of α‐iodo oximes.
ChemInform Abstract: Copper Catalyzed C—N Bond Formation/C—H Activation: Synthesis of Aryl 4H‐3,1‐Benzoxazin‐4‐ones.
Authors: Munusamy Sathishkumar , Venkatesan Sathesh , Sathiyanarayanan Kulathu Iyer
Published: April 2015

A facile protocol using CuI as catalyst and air as oxidant for the domino reaction of 2‐iodobenzoic acids and benzylamines to give the title compounds is presented.
ChemInform Abstract: Transition‐Metal‐Free Synthesis of Imidazobenzothiazines via Domino C—S/C—N Bond Formation.
Authors: Tu Xingzhao , Zhou Lihong , Li Zhijie , Lei Ning , Zeng Qingle
Published: April 2015

The title compounds are obtained from 2‐mercaptobenzimidazoles and 2‐halobenzyl bromides in an facile, environmentally friendly, and cost‐saving cascade process.
ChemInform Abstract: Tridentate Pyrrolylzinc Compounds: Synthesis, Structures, Reactivities and Catalytic Cyclotrimerization Reaction of Isocyanate.
Authors: Guo Zhiqiang , Wei Xuehong , Tong Hongbo , Liu Diansheng
Published: April 2015

Six new tridentate pyrrolylzinc compounds are synthesized and employed as initiator for the cyclotrimerization reaction of isocyanates (I).
ChemInform Abstract: Diversity Oriented Approach to Oxepine Derivatives: Further Expansion via Diels—Alder Reaction.
Authors: Kotha Sambasivarao , Ali Rashid
Published: April 2015

A mixture of oxepine derivatives (V) and (VI) is synthesized and used as latent dienes in various Diels—Alder reactions.
ChemInform Abstract: Novel Intramolecular Cyclization‐Skeletal Reorganization of 2‐Arylthiazoles under Photoirradiation.
Authors: Arai Noriyoshi , Ohkuma Takeshi , Mizota Moe
Published: April 2015

Photoirradiation of 2‐arylthiazoles (I) bearing an alkene moiety gives unexpectedly furan‐fused thiazepines (II) as the major products along with [2 + 2] adducts (III) and isothiazoles (IV).
ChemInform Abstract: Atom‐Efficient Regioselective 1,2‐Dearomatization of Functionalized Pyridines by an Earth‐Abundant Organolanthanide Catalyst.
Authors: Dudnik Alexander S. , Weidner Victoria L. , Motta Alessandro , Delferro Massimiliano , Marks Tobin J.
Published: April 2015

Cp*‐complexed lanthanum hydride dimer is used as catalyst in the 1,2‐selective hydroborylation of pyridines, quinoline and isoquinoline.
ChemInform Abstract: Dehydrogenative Silylation of Alcohols Catalyzed by Half‐Sandwich Iron N‐Heterocyclic Carbene Complexes.
Authors: Cardoso Joao M. S. , Lopes Rita , Royo Beatriz
Published: April 2015

Various tetramethylcyclopentadienyl‐functionalized N‐heterocyclic carbene iron complexes are synthesized which are found to be efficient catalysts for the dehydrogenative silylation of alcohols with silanes.
ChemInform Abstract: Addition of Vinylmetallic Reagents to Chiral 2‐Formyltetrahydrofuran.
Authors: Lamariano‐Merketegi Janire , Lorente Adriana , Gil Alejandro , Albericio Fernando , Alvarez Mercedes
Published: April 2015

A carboaluminum reaction, a Nozaki—Hiyama—Kishi reaction, and a chelation‐controlled organometallic addition are investigated for the introduction of a side chain to aldehydes (III) and (VI).
ChemInform Abstract: Facile Base‐Mediated Redox Transformation: An Efficient Strategy for the Synthesis of α‐Acyloxyphosphoryl Compounds.
Authors: Zhao Yalei , Chen Tieqiao , Han Daoqing , Zhao Chang‐Qiu , Han Li‐Biao
Published: April 2015

The atom‐efficient one‐pot synthesis succeeds using aromatic aldehydes and aromatic conjugated aldehydes, but fails using the corresponding aliphatic compounds or ketones.
ChemInform Abstract: Synthesis of Halo‐Enol Phostones by Using DMAP‐Catalyzed Halocyclization of Alkynylphosphonic Monoesters.
Authors: Huang Jiale , Wang Haiyang , Peng Ai‐Yun
Published: April 2015

The title reaction proceeds with high regioselectivity affording 6‐exo‐dig cyclization products as mixtures of E/Z‐isomers.
ChemInform Abstract: Enantioselective Selenocyclization via Dynamic Kinetic Resolution of Seleniranium Ions by Hydrogen‐Bond Donor Catalysts.
Authors: Zhang Hu , Lin Song , Jacobsen Eric N.
Published: April 2015

The enantiopurity of most products is further improved to <95% by recrystallization.
ChemInform Abstract: Dysotriflorins A—M, Triterpenoids from Dysoxylum densiflorum.
Authors: Morita Hiroshi , et al.
Published: April 2015

Thirteen new triterpenoids, dysotriflorins A‐M [e.g. A‐D (I)‐(IV)], are isolated.
ChemInform Abstract: Structures of Six New Compounds from Ligularia brassicoides.
Authors: Saito Yoshinori , Sasaki Yoko , Ohsaki Ayumi , Okamoto Yasuko , Gong Xun , Kuroda Chiaki , Tori Motoo
Published: April 2015

Four new eremophilane type sesquiterpenoids [e.g. (I)], a new bakkane type sesquiterpenoid (II), and a new secoeremophilane type sesquiterpenoid (III) are isolated from Ligularia brassicoides collected in China.
ChemInform Abstract: Chloranerectuslactone V (I), a New Sesquiterpene from Chloranthus erectus Verdc.
Authors: Huong Tran Thu , Thong Nguyen Van , Minh Tran Thi , Tram Le Huyen , Anh Nguyen Tuan , Cuong Ho Duc , Cuong Pham Van , Ca Diep V.
Published: April 2015

isolation and structured elucidation
ChemInform Abstract: Penicibilaenes A (Ia) and B (Ib), Sesquiterpenes with a Tricyclo[6.3.1.01,5]dodecane Skeleton from the Marine Isolate of Penicillium bilaiae MA‐267.
Authors: Meng Ling‐Hong , Li Xiao‐Ming , Liu Yang , Wang Bin‐Gui
Published: April 2015

The title compounds show antifungal activities against the plant pathogen C.
ChemInform Abstract: Secondary Metabolites from the Endophytic Fungus Xylaria cubensis
Authors: Fan Nai‐Wen , Chang Hsun‐Shuo , Cheng Ming‐Jen , Hsieh Sung‐Yuan , Liu Ta‐Wei , Yuan Gwo‐Fang , Chen Ih‐Sheng
Published: April 2015

isolation and structure determination of three new sesquiterpenoids, 10‐hydroxythujopsene (I), akotriol (II), and xylaritriol (III), one new diterpenoid, cubentriol (IV), one new aliphatic derivative, akoenic acid ((R)‐V), one new alkaloid, akodionine (VI), and one new isocoumarin, akolitserin (VII) along with seven known compounds from the fermentation broth of the endophytic fungus Xylaria cubensis
ChemInform Abstract: Diterpenoids from Aerial Parts of Clerodendranthus spicatus and Their Cytotoxic Activity.
Authors: Guan Shu‐Cai , Fan Guang‐Yan
Published: April 2015

The new diterpenoid, clerospicasin J (I), is isolated along with six known diterpenoids from the aerial parts of Clerodendranthus spicatus.
ChemInform Abstract: Halichonadins M—Q, Sesquiterpenes from an Okinawan Marine Sponge Halichondria sp.
Authors: Kobayashi Jun'ichi , Tanaka Naonobu , Suto Shohei , Asai Miki , Kusama Taishi , Takahashi‐Nakaguchi Azusa , Gonoi Tohru , Fromont Jane
Published: April 2015

Isolation and structure elucidation of four new dimeric sesquiterpenes, halichonadins M—P (I)—(IV) and new sesquiterpene, halichonadin Q (V), are described.
ChemInform Abstract: Access to Fluorine‐Containing Asparagine and Glutamine Analogues via Palladium‐Catalyzed Formate Reduction.
Authors: Usuki Yoshinosuke , Wakamatsu Yosuke , Yabu Minoru , Iio Hideo
Published: April 2015

The synthesis of asparagine and glutamine analogues (V) and (VIII) is based on Pd‐catalyzed reduction of enantiopure formates (I) and (VI).
ChemInform Abstract: Stereoselective Construction of 1β‐Azide‐ and 1β‐Cyano‐2‐deoxyribose Derivatives.
Authors: Fujioka Hiromichi , Okamoto Kazuhisa , Minamitsuji Yutaka , Ueyama Yoshifumi , Matsumoto Nao , Murai Kenichi , Moriya Takahiro
Published: April 2015

New methods for the β‐selective introduction of azido and cyano groups at the anomeric position of 2‐deoxyribose derivatives are developed.
ChemInform Abstract: Two Novel Isoquinoline Alkaloids from the Seedling of Corydalis decumbens.
Authors: Chang Jun , Chu Zhi‐Bo , Song Jiao , Jin Lin , Sun Xun
Published: April 2015

Decumbensine (I) and decumbendine (II) are isolated together with nine known compounds from the title seedling.
ChemInform Abstract: Germacranolides and Their Diversity of Eupatorium heterophyllum Collected in P. R. China.
Authors: Saito Yoshinori , Mukai Tomomi , Iwamoto Yuko , Baba Makiko , Takiguchi Koji , Okamoto Yasuko , Gong Xun , Kawahara Takayuki , Kuroda Chiaki , Tori Motoo
Published: April 2015

isolation and structure elucidation of 8 new hydroperoxyheterophyllin A—H (I)‐(V) and one ketoheterophyllin A (VI)
ChemInform Abstract: Cytotoxic Polyacetylenes from a Formosan Marine Sponge Callyspongia sp.
Authors: Chiu Ching‐Wen , Su Huey‐Jen , Lu Mei‐Chin , Wang Wei‐Hsien , Sheu Jyh‐Horng , Su Jui‐Hsin
Published: April 2015

Two new polyacetylenic compounds, callysponynes A (Ia) and B (Ib), are isolated.
ChemInform Abstract: Seimatoric Acid (I) and Colletonoic Acid (II): Two New Compounds from the Endophytic Fungi, Seimatosporium sp. and Colletotrichum sp.
Authors: Hussain Hidayat , et al.
Published: April 2015

Preliminary studies indicate that colletonoic acid (II) shows good antibacterial, antifungal, and antialgal activities.
ChemInform Abstract: Polyoxometalates as Ligands for Functional Lanthanoid Complexes
Authors: Ritchie Chris , Boskovic Colette
Published: April 2015

Review: 68 refs.
ChemInform Abstract: Guest‐Induced Emergent Properties in Metal‐Organic Frameworks
Authors: Allendorf Mark D. , Foster Michael E. , Leonard Francois , Stavila Vitalie , Feng Patrick L. , Doty F. Patrick , Leong Kirsty , Ma Eric Yue , Johnston Scott R. , Talin A. Alec
Published: April 2015

Review: 82 refs.
ChemInform Abstract: Recent Developments with Strained Metallocenophanes
Authors: Russell A. D. , Musgrave R. A. , Stoll L. K. , Choi P. , Qiu H. , Manners I.
Published: April 2015

Review: 103 refs.
ChemInform Abstract: Ultrasound Enhanced Laccase Applications
Authors: Goncalves Idalina , Silva Carla , Cavaco‐Paulo Artur
Published: April 2015

Review: 142 refs.
ChemInform Abstract: Hydrosilylation Reaction of Olefins: Recent Advances and Perspectives
Authors: Nakajima Y. , Shimada S.
Published: April 2015

Review: recent developments of efficient, selective, and cheaper hydrosilylation catalyst systems appearing in the last decade; 79 refs.
ChemInform Abstract: Ethynylglycine Synthon, a Useful Precursor for the Synthesis of Biologically Active Compounds: an Update ‐ Part I: Preparations of Ethynylglycine Synthon
Authors: Benfodda Zohra , Benimelis David , Reginato Gianna , Meffre Patrick
Published: April 2015

Review: update on the different routes for the synthesis of the ethynylglycine synthon (R)‐2,2‐dimethyl‐3‐(tert‐butoxycarbonyl)‐4‐ethynyloxazolidine, 56 refs.
ChemInform Abstract: Synthetic Strategies and Pharmacology of 2‐Oxo‐3‐cyanopyridine Derivatives: A Review
Authors: Ghosh Partha Sakha , Manna Kuntal , Banik Udayan , Das Manik , Sarkar Priyatosh
Published: April 2015

Review: 74 refs.
ChemInform Abstract: The Asymmetric Catalytic Mannich Reaction Catalyzed by Organocatalyst: a Personal Account
Authors: Hayashi Yujiro
Published: April 2015

Review: 126 refs.
ChemInform Abstract: Organocatalysis
Authors: Buckley Benjamin R.
Published: April 2015

Review: highlights in 2012 on highly enantioselective and achiral organocatalytic procsses; 37 refs.
ChemInform Abstract: Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes
Authors: Alonso Concepcion , Martinez de Marigorta Eduardo , Rubiales Gloria , Palacios Francisco
Published: April 2015

Review: 508 refs.
ChemInform Abstract: Copper‐Catalyzed Allylic Substitution and Conjugate Addition with Alkylboranes
Authors: Ohmiya Hirohisa , Sawamura Masaya
Published: April 2015

Review: 84 refs.
ChemInform Abstract: Chiral Dirhodium(II) Carboxylates and Carboxamidates as Effective Chemzymes in Asymmetric Synthesis of Three‐Membered Carbocycles
Authors: Adly Frady G. , Ghanem Ashraf
Published: April 2015

Review: 122 refs.
ChemInform Abstract: Solid‐Phase Guanidinylation of Peptidyl Amines Compatible with Standard Fmoc‐Chemistry: Formation of Mono‐Substituted Guanidines
Authors: Bionda Nina , Cudic Predrag
Published: April 2015

Review: 44 refs.
ChemInform Abstract: Solid‐Phase Peptide Synthesis: An Introduction
Authors: Jensen Knud J.
Published: April 2015

Review: 67 refs.
ChemInform Abstract: Sequential Formation of Regioselective Disulfide Bonds in Synthetic Peptides with Multiple Disulfide Bonds
Authors: Shabanpoor Fazel , Hossain Mohammed Akhter , Lin Feng , Wade John D.
Published: April 2015

Review: 15 refs.
ChemInform Abstract: Two Neglected Multicomponent Reactions: Asinger and Groebke Reaction for Constructing Thiazolines and Imidazolines
Authors: Liu Zai‐Qun
Published: April 2015

Review: 110 refs.
ChemInform Abstract: Trisubstituted Imidazole Synthesis: A Review
Authors: Rani Nidhi , Sharma Ajay , Singh Randhir
Published: April 2015

Review: 186 refs.
ChemInform Abstract: Metal‐Promoted Synthesis of Cyclic Carbonates from 1,2‐Diols and Carbon Dioxide
Authors: Guo Chun‐Xiang , Ma Ran , He Liang‐Nian
Published: April 2015

Review: 49 refs.
ChemInform Abstract: Under the Lens: Carbon Nanotube and Protein Interaction at the Nanoscale
Authors: Marchesan S. , Prato M.
Published: April 2015

Review: 112 refs.
ChemInform Abstract: Water Soluble Polythiophenes: Preparation and Applications
Authors: Das Sandip , Chatterjee Dhruba P. , Ghosh Radhakanta , Nandi Arun K.
Published: April 2015

Review: 129 refs.
ChemInform Abstract: A Computational View on the Reactions of Hydrocarbons with Coinage Metal Complexes
Authors: Besora Maria , Braga Ataualpa A. C. , Sameera W. M. C. , Urbano Juan , Fructos Manuel R. , Perez Pedro J. , Maseras Feliu
Published: April 2015

Review: 84 refs.
Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii
Authors: Chao María N. , Matiuzzi Carolina Exeni , Storey Melissa , Li Catherine , Szajnman Sergio H. , Docampo Roberto , Moreno Silvia N. J. , Rodriguez Juan B.
Published: April 2015

As a part of our project aimed at searching for new safe chemotherapeutic agents against parasitic diseases, several compounds structurally related to the antiparasitic agent WC‐9 (4‐phenoxyphenoxyethyl thiocyanate), which were modified at the terminal phenyl ring, were designed, synthesized, and evaluated as growth inhibitors against Trypanosoma cruzi, the etiological agent of Chagas disease, and Toxoplasma gondii, the parasite responsible of toxoplasmosis. Most of the synthetic analogues exhibited similar antiparasitic activity and were slightly more potent than our lead WC‐9. For example, two trifluoromethylated derivatives exhibited ED50 values of 10.0 and 9.2 μM against intracellular T. cruzi, whereas they showed potent action against tachyzoites of T. gondii (ED50 values of 1.6 and 1.9 μM against T. gondii). In addition, analogues of WC‐9 in which the terminal aryl group is in the meta position with respect to the alkyl chain bearing the thiocyanate group showed potent inhibitory action against both T. cruzi and T. gondii at the very low micromolar range, which suggests that a para‐phenyl substitution pattern is not necessary for biological activity.
Rational Design of Ruthenium Complexes Containing 2,6‐Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation
Authors: Deng Zhiqin , Yu Lianling , Cao Wenqiang , Zheng Wenjie , Chen Tianfeng
Published: April 2015

The rational design of metal‐based complexes is an effective strategy for the discovery of potent sensitizers for use in cancer radiotherapy. In this study, we synthesized three ruthenium complexes containing bis‐benzimidazole derivatives: Ru(bbp)Cl3 (1), [Ru(bbp)2]Cl2 (2 a) (in which bbp=2,6‐bis(benzimidazol‐1‐yl)pyridine), and [Ru(bnbp)2]Cl2 (2 b) (where bnbp=2,6‐bis‐(6‐nitrobenzimidazol‐2‐yl)pyridine). We evaluated their radiosensitization capacities in vitro and mechanisms of action. Complex 2 b was found to be particularly effective in sensitizing human melanoma A375 cells toward radiation, with a sensitivity enhancement ratio of 2.4. Along with this potency, complex 2 b exhibited a high degree of selectivity between human cancer and normal cells. Mechanistic studies revealed that 2 b promotes radiation‐induced accumulation of intracellular reactive oxygen species (ROS) by reacting with cellular glutathione (GSH) and then causing DNA stand breaks. The subsequent DNA damage induces phosphorylation of p53 (p‐p53) and upregulates the expression levels of p21, which inhibits the expression of cyclin‐B, leading to G2M arrest. Moreover, p‐p53 activates caspases‐3 and ‐8, triggers cleavage of poly(ADP‐ribose) polymerase (PARP), finally resulting in apoptosis. Taken together, the results of this study provide a strategy for the design of ruthenium‐based radiosensitizers for use in cancer therapy.
Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection
Authors: Bannas Peter , Lenz Alexander , Kunick Valentin , Well Lennart , Fumey William , Rissiek Björn , Haag Friedrich , Schmid Joanna , Schütze Kerstin , Eichhoff Anna , Trepel Martin , Adam Gerhard , Ittrich Harald , Koch‐Nolte Friedrich
Published: April 2015

The utility of nanobodies and conventional antibodies for in vivo imaging is well known, but optimum dosing and timing schedules for one versus the other have not been established. We aimed to improve specific tumor imaging in vivo with nanobodies and conventional antibodies using near‐infrared fluorescence (NIRF) imaging. We used ARTC2 expressed on lymphoma cells as a model target antigen. ARTC2‐specific nanobody s+16a and conventional antibody Nika102 were labeled with NIRF‐dye AF680. In vivo NIRF‐imaging of ARTC2‐positive and ARTC2‐negative xenografts was performed over 24 h post‐injection of 5, 10, 25, or 50 µg of each conjugate. Specific target‐binding and tissue‐penetration were verified by NIRF imaging ex vivo, flow cytometry and fluorescence microscopy. NIRF‐imaging of s+16a680 in vivo revealed a six times faster tumor accumulation than of Nika102680. Using 50 µg of s+16a680 increased the specific signals of ARTC2‐positive tumors without increasing background signals, allowing a tumor‐to‐background (T/B) ratio of 12.4 ± 4.2 within 6 h post‐injection. Fifty micrograms of Nika102680 increased specific signals of ARTC2‐positive tumors but also of ARTC2‐negative tumors and background, thereby limiting the T/B ratio to 6.1 ± 2.0. Ten micrograms of Nika102680 only slightly reduced specific tumor signals but dramatically reduced background signals. Ex vivo analyses confirmed a faster and deeper tumor penetration with s+16a680. Using nanobody s+16a allowed same‐day imaging with a high T/B ratio, whereas antibody Nika102 gave optimal imaging results only 24 h post injection. Nanobody s+16a required a high dose, whereas antibody Nika102 had the best T/B‐ratio at a low dose. Therefore, timing and dosage should be addressed when comparing nanobodies and conventional antibodies for molecular imaging purposes. Copyright © 2015 John Wiley & Sons, Ltd.
Evolving role of FNA biopsy in diagnosing lymphoma: Past, present, and future
Authors: Caraway Nancy P.
Published: April 2015

Despite being challenged more than a decade ago, fine‐needle aspiration biopsy continues to have a valuable role in diagnosing lymphomas. An updated lymphoma classification and several advances in technologies have aided in its increased acceptance and use; however, now is the time to integrate fine‐needle aspiration biopsy with ancillary studies and obtain material for potential molecular testing in the routine workup of lymphomas to ensure its continued use in the future.
Nanoflake‐Modulated La2Se3 Thin Films Prepared for an Asymmetric Supercapacitor Device
Authors: Patil Swati J. , Bulakhe Ravindra N. , Lokhande Chandrakant D.
Published: April 2015

La2Se3 nanoflakes were prepared from an aqueous medium by means of a chemical‐bath deposition method and were later utilized as a supercapacitor electrode. X‐ray diffraction (XRD), Fourier transform Raman (FT Raman), field‐emission scanning electron microscopy (FESEM), and contact‐angle measurement techniques were used to study the structural, morphological, and wettability properties of La2Se3 films. The XRD study confirmed the cubic crystal structure of the La2Se3 film. The surface morphology and wettability studies revealed the nanoflake morphology with a hydrophilic surface, which could be beneficial to electrochemical reactions. The electrochemical performance of the La2Se3 nanoflakes was evaluated by cyclic voltammetry (CV), galvanostatic charge/discharge (GCD), and electrochemical impedance spectroscopy (EIS) techniques. The La2Se3 nanoflake electrode exhibited a maximum specific capacitance of 331 F g−1 at a scan rate of 5 mV s−1. An electrochemical impedance study confirmed that the La2Se3 nanoflake electrode has a better supercapacitive behavior in an aqueous electrolyte. The asymmetric supercapacitor device based on the La2Se3 electrode in aqueous electrolyte exhibited good specific capacitance, excellent charge/discharge properties, and superior long‐term cycling stability.
Reduced Graphene Oxide Composite with Oxidizable Manganese/Cobalt Mixed Oxide for p‐Cresol Oxidation by Using Molecular Oxygen
Authors: Jha Ajay , Patil Sagar H. , Solanki Bhanu P. , Ribeiro Ana P. C. , Castro Carlos A. N. , Patil Kashinath R. , Coronas Alberto , Rode Chandrashekhar V.
Published: April 2015

A composite of graphene oxide (GO) with mixed oxide (MnCo) was prepared by using a solvothermal method. During the synthesis, both the reduction of GO and growth of metal oxides took place simultaneously. The as‐prepared composite material was highly selective for the liquid‐phase oxidation of p‐cresol to form p‐hydroxybenzaldehyde in 71 % yield within 1 h. The composite material was characterised by SEM, X‐ray photoelectron spectroscopy, high‐resolution TEM and cyclic voltammetry (CV). A CV study revealed that the increase in the redox potential of the mixed oxide after being supported on GO, led to its higher activity of the catalyst for the oxidation reaction. The stability of the catalyst under the reaction conditions was studied by its successful reuse in three cycles.
Phenolated Oleic Acid Based Polybenzoxazine Derivatives as Corrosion Protection Layers
Authors: Bălănucă Brindusa , Raicopol Matei , Maljusch Artjom , Garea Sorina , Hanganu Anamaria , Schuhmann Wolfgang , Andronescu Corina
Published: April 2015

Benzoxazine derivatives were synthesized using phenolated methyl oleate and either aniline, 1,6‐diaminohexane, or 4,4′‐diaminodiphenylmethane, respectively, as amine components. Polymerization of the benzoxazine derivatives led to the formation of hydrophobic and dense coatings on Zn‐Mg‐Al alloy coated steel sheets for passive corrosion protection. The polybenzoxazine coatings which are formed by crosslinking during a heat‐treatment step invoked a substantial anodic shift of the open‐circuit potential as well as the breakthrough potential in potentiodynamic measurements. The proposed polybenzoxazine derivatives pave the way for a new type of passive polymer protection system based on sustainably obtained precursor components.
Optimization and Insights into the Mechanism of Formation of Mechanically Interlocked Derivatives of Single‐Walled Carbon Nanotubes
Authors: de Juan Alberto , Mar Bernal M. , Pérez Emilio M.
Published: April 2015

The mechanical bond provides a stable yet dynamic link between the submolecular components of mechanically interlocked molecules, such as rotaxanes and catenanes. We introduced the mechanical bond as a new tool for the chemical modification of single‐walled carbon nanotubes (SWNTs), producing the first mechanically interlocked derivatives of nanotubes (MINTs). To do so, we used U‐shaped molecules featuring two units of a SWNT‐recognition unit, which were cyclized around the SWNT by means of ring‐closing metathesis (RCM). Here we report optimized conditions for the synthesis of MINTs obtained by systematic investigation of the effect of the concentration of the U‐shaped molecule 1, reaction time, and catalyst concentration. Analysis of the data also provides insights into the mechanism of formation of MINTs. In particular, the effect of the concentration of 1 supports the formation of a 1⋅SWNT complex. The kinetic data follow a pseudo‐first‐order behavior that validates the RCM as the rate‐determining step. An excess of RCM catalyst leads to the formation of supramolecularly adsorbed linear oligomers of 1.
Alternative reproductive tactics in snail shell‐brooding cichlids diverge in energy reserve allocation
Authors: von Kuerthy Corinna , Tschirren Linda , Taborsky Michael
Published: April 2015

Life history theory predicts that the amount of resources allocated to reproduction should maximize an individual's lifetime reproductive success. So far, resource allocation in reproduction has been studied mainly in females. Intraspecific variation of endogenous energy storage and utilization patterns of males has received little attention, although these patterns may vary greatly between individuals pursuing alternative reproductive tactics (ARTs). ARTs are characterized by systematic variation of behavioral, physiological, and often morphological traits among same‐sex conspecifics. Some individuals may rely on previously accumulated reserves, because of limited foraging opportunities during reproduction. Others may be able to continue foraging during reproduction, thus relying on reserves to a lesser extent. We therefore predicted that, if male tactics involve such divergent limitations and trade‐offs within a species, ARTs should correspondingly differ in energy reserve allocation and utilization. To test this prediction, we studied short‐term and long‐term reserve storage patterns of males in the shell‐brooding cichlid Lamprologus callipterus. In this species, bourgeois males investing in territory defense, courtship, and guarding of broods coexist with two distinct parasitic male tactics: (1) opportunistic sneaker males attempting to fertilize eggs by releasing sperm into the shell opening when a female is spawning; and (2) specialized dwarf males attempting to enter the shell past the spawning female to fertilize eggs from inside the shell. Sneaker males differed from other male types by showing the highest amount of accumulated short‐term and long‐term fat stores, apparently anticipating their upcoming adoption of the nest male status. In contrast, nest males depleted previously accumulated energy reserves with increasing nest holding period, as they invest heavily into costly reproductive behaviors while not taking up any food. This conforms to a capital breeder strategy. Dwarf males did not accumulate long‐term fat stores at all, which they can afford due to their small behavioral effort during reproduction and their continued feeding activity, conforming to an income breeder strategy. Our data confirm that the resource storage patterns of males pursuing ARTs can diverge substantially, which adds to our understanding of the coexistence and maintenance of alternative reproductive patterns within species.
Analyzing large‐scale conservation interventions with Bayesian hierarchical models: a case study of supplementing threatened Pacific salmon
Authors: Scheuerell Mark D. , Buhle Eric R. , Semmens Brice X. , Ford Michael J. , Cooney Tom , Carmichael Richard W.
Published: April 2015

Myriad human activities increasingly threaten the existence of many species. A variety of conservation interventions such as habitat restoration, protected areas, and captive breeding have been used to prevent extinctions. Evaluating the effectiveness of these interventions requires appropriate statistical methods, given the quantity and quality of available data. Historically, analysis of variance has been used with some form of predetermined before‐after control‐impact design to estimate the effects of large‐scale experiments or conservation interventions. However, ad hoc retrospective study designs or the presence of random effects at multiple scales may preclude the use of these tools. We evaluated the effects of a large‐scale supplementation program on the density of adult Chinook salmon Oncorhynchus tshawytscha from the Snake River basin in the northwestern United States currently listed under the U.S. Endangered Species Act. We analyzed 43 years of data from 22 populations, accounting for random effects across time and space using a form of Bayesian hierarchical time‐series model common in analyses of financial markets. We found that varying degrees of supplementation over a period of 25 years increased the density of natural‐origin adults, on average, by 0–8% relative to nonsupplementation years. Thirty‐nine of the 43 year effects were at least two times larger in magnitude than the mean supplementation effect, suggesting common environmental variables play a more important role in driving interannual variability in adult density. Additional residual variation in density varied considerably across the region, but there was no systematic difference between supplemented and reference populations. Our results demonstrate the power of hierarchical Bayesian models to detect the diffuse effects of management interventions and to quantitatively describe the variability of intervention success. Nevertheless, our study could not address whether ecological factors (e.g., competition) were more important than genetic considerations (e.g., inbreeding depression) in determining the response to supplementation.