bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance and Configuration of Artificial Intelligence in Educational Settings. Introducing a New Reliability Concept Based on Content Analysis
Authors: Berding Florian , Riebenbauer Elisabeth , Stütz Simone , Jahncke Heike , Slopinski Andreas , Rebmann Karin
Published: May 2022

Learning analytics represent a promising approach for fostering personalized learning processes. Most applications of this technology currently do not use textual data for providing information on learning, or for deriving recommendations for further development. This paper presents the results of three studies aiming to make textual information usable. In the first study, the iota concept is introduced as a new content analysis measure to evaluate inter-coder reliability. The main advantage of this new concept is that it provides a reliability estimation for every single category, allowing deeper insight into the quality of textual analysis. The second study simulates the process of content analysis, comparing the new iota concept with well-established measures (e.g., Krippendorff’s Alpha, percentage agreement). The results show that the new concept covers the true reliability of a coding scheme, and is not affected by the number of coders or categories, the sample size, or the distribution of data. Furthermore, cut-off values are derived for judging the quality of the analysis. The third study employs the new concept, as it analyzes the performance of different artificial intelligence (AI) approaches for interpreting textual data based on 90 different constructs. The texts used here were either created by apprentices, students, and pupils, or were taken from vocational textbooks. The paper shows that AI can reliably interpret textual information for learning purposes, and also provides recommendations for optimal AI configuration.
Pregnancy and Perinatal Outcomes of Patients With Prior Cesarean Section After a Single Embryo Transfer in IVF/ICSI: A Retrospective Cohort Study
Authors: Wang Lin , Wang Jing , Lu Nan , Liu Jiayin , Diao Feiyang
Published: May 2022

Objective

To study the influence of the previous cesarean section on the pregnancy outcomes and perinatal outcomes in single embryo transfer (SET) cycles in an in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) setting compared to those with previous vaginal delivery (VD). In addition, the association between fertility outcomes and different cesarean scar defect (CSD) sizes was studied.

Method

This was a retrospective cohort study conducted in the Reproductive Center of the First Affiliated Hospital of Nanjing Medical University. A total of 4,879 patients with previous delivery history undergoing SET were included between January 2015 and April 2019. Patients were divided into the VD group and cesarean delivery (CD) group according to different modes of previous delivery. The primary outcome was live birth rate. The pregnancy outcomes of CD were analyzed as a subgroup and the relationship between pregnancy outcomes as well as the different sizes of CSD were explored by logistic regression analysis.

Results

There were no significant differences in live birth rate, clinical pregnancy rate, and miscarriage rate between the CD group and VD group. The incidence rates of pregnancy complications such as pregnancy hypertension, gestational diabetes mellitus, placenta abnormalities, premature rupture of membrane, and postpartum hemorrhage were similar in the two groups. Live birth rate was significantly lower in the CSD group (23.77% vs 37.01%, aOR: 0.609, 95% CI: 0.476-0.778) comparing to patients without CSD. There were also significant differences in clinical pregnancy rate (37.52% vs 47.64%, aOR: 0.779, 95%CI: 0.623-0.973) and miscarriage rate (34.55% vs 20.59%, aOR: 1.407, 95%CI:1.03-1.923). Large size CSD significantly decreased live birth rate (13.33% vs 26.29%, aOR: 0.422, 95%CI: 0.197-0.902) and clinical pregnancy rate (25.33% vs 40.09%, aOR: 0.503, 95%CI: 0.272-0.930) compared with small size CSD.

Conclusion

For women with previous cesarean sections, the pregnancy outcomes were similar to those with previous VD without increased perinatal complications following SET. The presence of CSD was associated with a marked reduction in live birth rate, especially in patients with large size CSD.
Modulating Effects of Landscape Characteristics on Responses to Warming Differ Among Butterfly Species
Authors: Hellegers Marjon , van Swaay Chris A. M. , van Hinsberg Arjen , Huijbregts Mark A. J. , Schipper Aafke M.
Published: May 2022

Understanding and predicting biodiversity responses to climate change are vital to inform conservation strategies, but this is not straightforward as climate change responses depend on the landscape context and differ among species. Here, we quantified changes in the distribution and abundance of 30 butterfly species in the Netherlands in relation to climate change and in landscapes that vary in the amount and connectivity of (semi-)natural vegetation (SNV). We obtained yearly counts of well-monitored butterfly species from 327 time series over 27 years (1992–2018). We used these counts to build mixed effect hurdle models to relate species’ occurrence and abundance to temperature and the amount and connectivity of SNV around the sites. For 55% of the butterfly species, an increased amount or connectivity of SNV corresponded with stronger increases or reduced decreases in occurrence in response to warming, indicating that SNV may facilitate range expansion or mitigate extirpations due to climate change. However, for the occurrence of the other species we found no or a negative interaction between warming and SNV. Further, we did not find indications of a mitigating effect of SNV on abundance responses to warming. Our results thus suggest that increasing the amount and connectivity of SNV does not offer a “one-size-fits-all” solution, highlighting the need for additional measures if butterfly diversity is to be conserved.
Sources and Cycling of Particulate Organic Matter in Baffin Bay: A Multi-Isotope δ13C, δ15N, and Δ14C Approach
Authors: Fox Aislinn , Walker Brett D.
Published: May 2022

The Canadian Arctic is warming three times faster than the rest of the planet. The impact of climate change on the Arctic carbon cycle, and in particular for Baffin Bay, remains poorly constrained. Sinking particulate organic matter (POMsink) is a key component of the biological carbon pump and provides a direct linkage between surface productivity and the preservation of carbon in marine sediments. While POMsink provides a rapid POM shunt to the deep ocean (days) the majority of marine POM is suspended (POMsusp) persists for years in the water column. Stable carbon (δ13C), nitrogen (δ15N) and radiocarbon (Δ14C) measurements are powerful tools for evaluating sources and cycling of POM. In this study, we measure depth-integrated (0-400m) POMsusp stable carbon (δ13C), nitrogen (δ15N) and radiocarbon (Δ14C) values at 11 stations in Baffin Bay. We use POM C:Na ratios to evaluate its diagenetic state. POMsusp δ13C and δ15N values ranged from −21.6‰ to −29.5‰, and +3.84‰ to +7.21‰, respectively. POMsusp Δ14C values ranged from −41.8‰ to +76.8‰. Together, our results suggest Baffin Bay POMsusp has multiple carbon and nitrogen sources. POMsusp δ13C and Δ14C are strongly correlated to surface salinity, indicating surface water has a strong influence on POMsusp isotopic composition and 14C-age. POMsusp from coastal Greenland stations have similar Δ14C values to surface dissolved inorganic carbon (DIC) and POM concentrations, consistent with primary production as the predominant POMsusp source in Eastern Baffin Bay. Positive POMsusp Δ14C values in central Baffin Bay suggest an accumulation of atmospheric “bomb” 14C in the sub-polar gyre. POMsusp exiting Davis Strait via the Baffin Island Current was determined to have a significant degraded, resuspended sediment component. Finally, POMsusp δ15N values highlight two distinct N sources in Baffin Bay: Pacific and Arctic nutrients at Northern gateway stations vs. the influx of Atlantic nutrients via Davis Strait along coastal Greenland. Overall, these first Baffin Bay POMsusp Δ14C values provide useful baseline data for rapidly changing Arctic ecosystem.
Tensile and Microscopic Properties of High-Density Polyethylene Geonet for Rainwater Scour Resistance
Authors: Liu Luliang , Dou Yuanming
Published: May 2022

In order to study the tensile properties of a high-density polyethylene (HDPE) geonet for rainwater scour resistance and the micro properties of HDPE after tensile failure, a series of tensile tests on the HDPE geonet were carried out by the material testing system (MTS) tensile device. In this study, a correlation has been proposed to analyze the relationship between elongation and tensile strength of geonet material. The microscopic characteristics of the HDPE geonet were observed by using a scanning electron microscope SU8000. The high-density polyethylene geonet for rainwater scour resistance was evaluated based on mechanical performance and microstructure. The rainwater scour resistance properties of the high-density polyethylene geonet were estimated. It is determined that the geonet improved the rainwater scour resistance of the soil slope. The mechanical test results indicated that the longitudinal mechanical properties of the geonet are better than the transversal. The scanning electron microscope images of the geonet results confirmed that the polyethylene polymer produces fine and neat radial cracks during the tensile process of the geonet. The findings of this work are essential for the fundamental understanding, design, and application of the geonet.
Small Airways: The “Silent Zone” of 2021 GINA Report?
Authors: Cottini Marcello , Lombardi Carlo , Passalacqua Giovanni , Bagnasco Diego , Berti Alvise , Comberiati Pasquale , Imeri Gianluca , Landi Massimo , Heffler Enrico
Published: May 2022

Asthma is a chronic disease, affecting approximately 350 million people worldwide. Inflammation and remodeling in asthma involve the large airways, and it is now widely accepted that the small airways (those with an internal diameter <2 mm) are involved in the pathogenesis of asthma and are the major determinant of airflow obstruction in this disease. From a clinical perspective, small airways dysfunction (SAD) is associated with more severe bronchial hyperresponsiveness, worse asthma control and more exacerbations. Unlike the GOLD guidelines which, in their definition, identify COPD as a disease of the small airways, the Global Initiative for Asthma (GINA) guidelines do not refer to the prevalence and role of SAD in asthmatic patients. This decision seems surprising, given the growing body of compelling evidence accumulating pointing out the high prevalence of SAD in asthmatic patients and the importance of SAD in poor asthma control. Furthermore, and remarkably, SAD appears to possess the characteristics of a treatable pulmonary trait, making it certainly appealing for asthma control optimization and exacerbation rate reduction. In this mini-review article, we address the most recent evidence on the role of SAD on asthma control and critically review the possible inclusion of SAD among treatable pulmonary traits in international guidelines on asthma.
Characterization of a Deep-Sea Actinobacterium Strain Uncovers Its Prominent Capability of Utilizing Taurine and Polyvinyl Alcohol
Authors: Tan Yingqi , Shan Yeqi , Zheng Rikuan , Liu Rui , Sun Chaomin
Published: May 2022

Actinobacteria represent a large group of important prokaryotes with great application potentials and widely distribute in diverse natural environments including the ocean. However, compared to their terrestrial cultured members, there are much less available marine Actinobacteria, especially deep-sea counterparts. Here, we cultured a bacterial strain of deep-sea actinobacterium, Marmoricola sp. TYQ2, by using a basal medium supplemented with taurine. Consistently, the growth of strain TYQ2 was significantly promoted by the supplement of taurine. Transcriptomic analysis showed that the expressions of genes encoding proteins associated with taurine metabolization and utilization as well as energy generation were evidently up-regulated when taurine was added. Moreover, strain TYQ2 was demonstrated to degrade polyvinyl alcohol (PVA) with the involvement of the redox cycle of extracellular quinol and quinone and the reduction of iron to ferrous, and strain TYQ2 could utilize the degradation products for energy production, thereby supporting bacterial growth. Overall, our experimental results demonstrate the prominent degradation capabilities of Marmoricola sp. TYQ2 toward the organics taurine and PVA.
Dynamic Cloth Manipulation Considering Variable Stiffness and Material Change Using Deep Predictive Model With Parametric Bias
Authors: Kawaharazuka Kento , Miki Akihiro , Bando Masahiro , Okada Kei , Inaba Masayuki
Published: May 2022

Dynamic manipulation of flexible objects such as fabric, which is difficult to modelize, is one of the major challenges in robotics. With the development of deep learning, we are beginning to see results in simulations and some actual robots, but there are still many problems that have not yet been tackled. Humans can move their arms at high speed using their flexible bodies skillfully, and even when the material to be manipulated changes, they can manipulate the material after moving it several times and understanding its characteristics. Therefore, in this research, we focus on the following two points: (1) body control using a variable stiffness mechanism for more dynamic manipulation, and (2) response to changes in the material of the manipulated object using parametric bias. By incorporating these two approaches into a deep predictive model, we show through simulation and actual robot experiments that Musashi-W, a musculoskeletal humanoid with a variable stiffness mechanism, can dynamically manipulate cloth while detecting changes in the physical properties of the manipulated object.
Making Every Step Count: Minute-by-Minute Characterization of Step Counts Augments Remote Activity Monitoring in People With Multiple Sclerosis
Authors: Block Valerie J. , Waliman Matthew , Xie Zhendong , Akula Amit , Bove Riley , Pletcher Mark J. , Marcus Gregory M. , Olgin Jeffrey E. , Cree Bruce A. C. , Gelfand Jeffrey M. , Henry Roland G.
Published: May 2022

Background

Ambulatory disability is common in people with multiple sclerosis (MS). Remote monitoring using average daily step count (STEPS) can assess physical activity (activity) and disability in MS. STEPS correlates with conventional metrics such as the expanded disability status scale (Expanded Disability Status Scale; EDSS), Timed-25 Foot walk (T25FW) and timed up and go (TUG). However, while STEPS as a summative measure characterizes the number of steps taken over a day, it does not reflect variability and intensity of activity.

Objectives

Novel analytical methods were developed to describe how individuals spends time in various activity levels (e.g., continuous low versus short bouts of high) and the proportion of time spent at each activity level.

Methods

94 people with MS spanning the range of ambulatory impairment (unaffected to requiring bilateral assistance) were recruited into FITriMS study and asked to wear a Fitbit continuously for 1-year. Parametric distributions were fit to minute-by-minute step data. Adjusted R2 values for regressions between distributional fit parameters and STEPS with EDSS, TUG, T25FW and the patient-reported 12-item MS Walking scale (MSWS-12) were calculated over the first 4-weeks, adjusting for sex, age and disease duration.

Results

Distributional fits determined that the best statistically-valid model across all subjects was a 3-compartment Gaussian Mixture Model (GMM) that characterizes the step behavior within 3 levels of activity: high, moderate and low. The correlation of GMM parameters for baseline step count measures with clinical assessments was improved when compared with STEPS (adjusted R2 values GMM vs. STEPS: TUG: 0.536 vs. 0.419, T25FW: 0.489 vs. 0.402, MSWS-12: 0.383 vs. 0.378, EDSS: 0.557 vs. 0.465). The GMM correlated more strongly (Kruskal-Wallis: p = 0.0001) than STEPS and gave further information not included in STEPS.

Conclusions

Individuals' step distributions follow a 3-compartment GMM that better correlates with clinic-based performance measures compared with STEPS. These data support the existence of high-moderate-low levels of activity. GMM provides an interpretable framework to better understand the association between different levels of activity and clinical metrics and allows further analysis of walking behavior that takes step distribution and proportion of time at three levels of intensity into account.
Cerebral Microbleeds Assessment and Quantification in COVID-19 Patients With Neurological Manifestations
Authors: Napolitano Angela , Arrigoni Alberto , Caroli Anna , Cava Mariangela , Remuzzi Andrea , Longhi Luca Giovanni , Barletta Antonino , Zangari Rosalia , Lorini Ferdinando Luca , Sessa Maria , Gerevini Simonetta
Published: May 2022

It is increasingly acknowledged that Coronavirus Disease 2019 (COVID-19) can have neurological manifestations, and cerebral microbleeds (CMBs) have been observed in this setting. The aim of this study was to characterize CMBs patterns on susceptibility-weighted imaging (SWI) in hospitalized patients with COVID-19 with neurological manifestations. CMBs volume was quantified and correlated with clinical and laboratory parameters. The study included patients who were hospitalized due to COVID-19, exhibited neurological manifestations, and underwent a brain MRI between March and May 2020. Neurological, clinical, and biochemical variables were reported. The MRI was acquired using a 3T scanner, with a standardized protocol including SWI. Patients were divided based on radiological evidence of CMBs or their absence. The CMBs burden was also assessed with a semi-automatic SWI processing procedure specifically developed for the purpose of this study. Odds ratios (OR) for CMBs were calculated using age, sex, clinical, and laboratory data by logistic regression analysis. Of the 1,760 patients with COVID-19 admitted to the ASST Papa Giovanni XXIII Hospital between 1 March and 31 May 2020, 116 exhibited neurological symptoms requiring neuroimaging evaluation. Of these, 63 patients underwent brain MRI and were therefore included in the study. A total of 14 patients had radiological evidence of CMBs (CMBs+ group). CMBs+ patients had a higher prevalence of CSF inflammation (p = 0.020), a higher white blood cell count (p = 0.020), and lower lymphocytes (p = 0.010); the D-dimer (p = 0.026), LDH (p = 0.004), procalcitonin (p = 0.002), and CRP concentration (p < 0.001) were higher than in the CMBs- group. In multivariable logistic regression analysis, CRP (OR = 1.16, p = 0.011) indicated an association with CMBs. Estimated CMBs volume was higher in females than in males and decreased with age (Rho = −0.38; p = 0.18); it was positively associated with CRP (Rho = 0.36; p = 0.22), and negatively associated with lymphocytes (Rho = −0.52; p = 0.07). CMBs are a frequent imaging finding in hospitalized patients with COVID-19 with neurological manifestations and seem to be related to pro-inflammatory status.
EpiBOX: An Automated Platform for Long-Term Biosignal Collection
Authors: Carmo Ana Sofia , Abreu Mariana , Fred Ana Luísa Nobre , da Silva Hugo Plácido
Published: May 2022

Biosignals represent a first-line source of information to understand the behavior and state of human biological systems, often used in machine learning problems. However, the development of healthcare-related algorithms that are both personalized and robust requires the collection of large volumes of data to capture representative instances of all possible states. While the rise of flexible biosignal acquisition solutions has enabled the expedition of data collection, they often require complicated frameworks or do not provide the customization required in some research contexts. As such, EpiBOX was developed as an open-source, standalone, and automated platform that enables the long-term acquisition of biosignals, passable to be operated by individuals with low technological proficiency. In particular, in this paper, we present an in-depth explanation of the framework, methods for the evaluation of its performance, and the corresponding findings regarding the perspective of the end-user. The impact of the network connection on data transfer latency was studied, demonstrating innocuous latency values for reasonable signal strengths and manageable latency values even when the connection was unstable. Moreover, performance profiling of the EpiBOX user interface (mobile application) indicates a suitable performance in all aspects, providing an encouraging outlook on adherence to the system. Finally, the experience of our research group is described as a use case, indicating a promising outlook regarding the use of the EpiBOX framework within similar contexts. As a byproduct of these features, our hope is that by empowering physicians, technicians, and monitored subjects to supervise the biosignal collection process, we enable researchers to scale biosignal collection.
Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study
Authors: Liu Huamin , Wang Zhenghe , Zou Lianwu , Gu Shanyuan , Zhang Minyi , Hukportie Daniel Nyarko , Zheng Jiazhen , Zhou Rui , Yuan Zelin , Wu Keyi , Huang Zhiwei , Zhong Qi , Huang Yining , Wu Xianbo
Published: May 2022

The relationship between body mass index (BMI) and cognitive impairment remains controversial, especially in older people. This study aims to confirm the association of phenotypic and genetic obesity with cognitive impairment and the benefits of adhering to a healthy lifestyle. This prospective study included 10,798 participants (aged ≥ 50 years) with normal cognitive function from the Health and Retirement Study in the United States. Participants were divided into low (lowest quintile), intermediate (quintiles 2–4), and high (highest quintile) groups according to their polygenic risk score (PRS) for BMI. The risk of cognitive impairment was estimated using Cox proportional hazard models. Higher PRS for BMI was associated with an increased risk, whereas phenotypic obesity was related to a decreased risk of cognitive impairment. Never smoking, moderate drinking, and active physical activity were considered favourable and associated with a lower risk of cognitive impairment compared with current smoking, never drinking, and inactive, respectively. A favourable lifestyle was associated with a low risk of cognitive impairment, even in subjects with low BMI and high PRS for BMI. This study suggest that regardless of obesity status, including phenotypic and genetic, adhering to a favourable lifestyle is beneficial to cognitive function.
Comparative Study Regarding the Adherence to the Mediterranean Diet Among Older Adults Living in Lebanon and Syria
Authors: Karam Joanne , Serhan Carole , Swaidan Eman , Serhan Mireille
Published: May 2022

The Mediterranean diet (MedDiet) has been associated with many health benefits. Poor adherence to MedDiet has been found among Lebanese adults, while in Syria, little is known about the adherence to MedDiet. A quantitative research approach was used, and data were collected through convenience sampling. The structure of the survey included the socio-economic and demographic data and the validated 14-point MedDiet assessment tool. The target population included 367 Lebanese and Syrian adults respectively residing in Lebanon and Syria. Descriptive statistics were used to explore the characteristics of the sample population. Adequate adherence MedDiet was determined if the Med-Diet score ≥ 9. Significant differences among the variables and the adherence to the MedDiet were examined using the chi-square test. Approximately 47.42% of participants reported adherence to MedDiet higher than 9, with a mean of 7.98. Lebanese participants, men, and those who are aged between 64 and 67, had higher adherence than Syrian participants, women, and other age groups, respectively. Lebanese participants (7.82 ± 2.32) had slightly higher adherence than Syrian participants (7.31 ± 2.04). Wine, sofrito, vegetables, and olive oil were mostly consumed by participants, with differences in consumption between the Lebanese and Syrian adults. The statistical analysis performed using the chi-square test showed no statistical difference (P>.05) between Lebanese and Syrian participants regarding their consumption of 160 red meat, butter/margarine, and sugary drinks. Future studies in the aged population are required to explore furthermore the adherence to MedDiet in Lebanon and Syria and its impact on health.
Emerging Role of Carbon Ion Radiotherapy in Reirradiation of Recurrent Head and Neck Cancers: What Have We Achieved So Far?
Authors: Bhattacharyya Tapesh , Koto Masashi , Windisch Paul , Ikawa Hiroaki , Hagiwara Yasuhito , Tsuji Hiroshi , Adeberg Sebastian
Published: May 2022

Administering reirradiation for the treatment of recurrent head and neck cancers is extremely challenging. These tumors are hypoxic and radioresistant and require escalated radiation doses for adequate control. The obstacle to delivering this escalated dose of radiation to the target is its proximity to critical organs at risk (OARs) and possible development of consequent severe late toxicities. With the emergence of highly sophisticated technologies, intensity-modulated radiotherapy (IMRT) and stereotactic body radiotherapy have shown promising outcomes. Proton beam radiotherapy has been used for locally recurrent head and neck cancers because of its excellent physical dose distribution, exploring sharp Bragg peak properties with negligible entrance and exit doses. To further improve these results, carbon ion radiotherapy (CIRT) has been explored in several countries across Europe and Asia because of its favorable physical properties with minimal entrance and exit doses, sharper lateral penumbra, and much higher and variable relative biological efficacy, which cannot be currently achieved with any other form of radiation. Few studies have described the role of CIRT in recurrent head and neck cancers. In this article, we have discussed the different aspects of carbon ions in reirradiation of recurrent head and neck cancers, including European and Asian experiences, different dose schedules, dose constraints of OARs, outcomes, and toxicities, and a brief comparison with proton beam radiotherapy and IMRT.
Case Report: PTEN Mutation Induced by anti-PD-1 Therapy in Stage IV Lung Adenocarcinoma
Authors: Teng Junjie , Zhou Kai , Lv Dongxiao , Wu Changshun , Feng Hong
Published: May 2022

Lung cancer is the most common solid tumor in the worldwide. Targeted therapy and immunotherapy are important treatment options in advanced non-small cell lung cancer (NSCLC). The association of PTEN mutation and tumor immunotherapy is less established for patients with NSCLC. We present the case of an Asian woman diagnosed with stage IV lung adenocarcinoma harboring an ERBB2 mutation. She received Nivolumab treatment when her disease progresses after previous chemotherapy and Afatinib treatment. However, the patient did not response to Nivolumab. PTEN mutation was detected by next-generation sequencing (NGS) after treatment with Nivolumab. PTEN, a secondary mutation, may be served as a biomarker of resistance to anti-PD-1 immunotherapy in lung adenocarcinoma. The relationship between PTEN mutation and immunotherapy is complex and needs further study.
Discriminative Monitoring of Seamless Rail Force by a High-Birefringence Effect-Based Fiber Optic Sensing Method
Authors: Zhou Yin , Yan Lianshan , Wang Ping , Chen Rong , Li Zonglei , Ye Jia , Pan Wei , Luo Bin
Published: May 2022

Nowadays, China has developed over 38,000-km high-speed railways (HSR). As one of the key elements in the HSR system, continuous welded rail (CWR) enables higher transportation efficiency, while demands for more robust inspection and maintenance techniques. The discrimination between longitudinal temperature force and longitudinal additional force is one of the main challenges in the rail health status evaluations. In this paper, the high-birefringence fiber Bragg grating (HB-FBG) is applied to reach the rail force discriminative measurement. By inscribing the Bragg grating on a high-birefringence fiber, two kinds of sensing modes can be generated and adopted to realize the discriminative measurement of longitudinal temperature force and longitudinal additional force. In the verification experiments, the longitudinal temperature and additional force are accurately measured with the error less than 1 kN. The accurate-measurement and easy-manufacture of the HB-fiber and HB-FBG make it possible to connect massive sensors in series to reach long-range monitoring of the rails on the land or cross-sea bridges.
Sex Modulates Cardiovascular Effects of Icodextrin-Based Peritoneal Dialysis Solutions
Authors: Paniagua Ramón , García-López Elvia , Ávila-Díaz Marcela , Ventura María-de-Jesús , Orihuela Oscar , Prado-Uribe María-del-Carmen , Gallardo-Montoya Juan-Manuel , Lindholm Bengt
Published: May 2022

Background/Aims: Some previous observations have noted that after six months of peritoneal dialysis (PD) treatment with icodextrin solutions, blood pressure (BP) and NT-proBNP tend to return to baseline values. This may be due to accumulation of icodextrin products that exert a colloid osmotic effect, which drives water into the bloodstream, causing the rise in blood pressure. Since icodextrin is metabolized by α-Amylase and its gene copies are lower in females than in males, we hypothesized icodextrin metabolites reach higher concentrations in females and that cardiovascular effects of icodextrin are influenced by sex.

Methods: Secondary analysis of a RCT comparing factors influencing fluid balance control in diabetic PD patients with high or high average peritoneal transport receiving icodextrin (n = 30) or glucose (n = 29) PD solutions. Serum icodextrin metabolites, osmolality, body composition and Inferior Vena Cava (IVC) diameter were measured at baseline, and at 6 and 12 months of follow-up.

Results: After six months of treatment, icodextrin metabolites showed higher levels in females than in males, particularly G5-7 and >G7, serum osmolality was lower in females. In spite of reduction in total and extracellular body water, ultrafiltration (UF) was lower and IVC diameter and BP increased in females, suggesting increment of blood volume.

Conclusion: Females undergoing PD present with higher levels of icodextrin metabolites in serum that may exert an increased colloid-osmotic pressure followed by less UF volumes and increment in blood volume and blood pressure. Whether this could be due to the lesser number of α-Amylase gene copies described in diabetic females deserves further investigation.
Population-Based Psychiatric Comorbidity in Children and Adolescents With Autism Spectrum Disorder: A Meta-Analysis
Authors: Mutluer Tuba , Aslan Genç Herdem , Özcan Morey Aslihan , Yapici Eser Hale , Ertinmaz Beliz , Can Merve , Munir Kerim
Published: May 2022

Psychiatric comorbidity in autism spectrum disorder (ASD) is a subject of critical scientific importance, affecting the quality of life, prognosis, and functional outcomes. The prevalence of psychiatric disorders vary considerably according to variables such as index subject characteristics, study setting, sampling frame, diagnostic methods used, as well as country of geographic origin. To date, most studies comprise clinical or treatment referral samples in tertiary care or subjects enrolled in clinical trials and genetic cohort collections. Such samples carry the potential for overestimation of both the frequency and severity of psychiatric comorbidity. A systematic literature search was performed using PubMed and Web of Science databases restricted to population-based study publications in the English between May 1, 2015, and May 31, 2020. A comprehensive keyword list was generated to investigate co-occurrence of psychiatric disorders in children and adolescents with ASD. A wide range of DSM-5 based disorders such as anxiety, mood, ADHD, intellectual disability/intellectual developmental disorder, eating/feeding, gender dysphoria and sleep-wake disorders were assessed. Initial search revealed a total of 1674 articles after removal of duplicates. Two independent researchers conducted a parallel-blinded screening process to identify the eligible studies based on titles and abstracts; 39 studies were analyzed in the current review. The main findings show prevalence estimates of 22.9% (95% CI: 17.7- 29.2) for intellectual disability; 26.2% (22-31) for attention-deficit hyperactivity disorder; 11.1% (8.6-14.1) for anxiety disorders; 19.7% (11.9-30.7) for sleep disorders; 7% (5.2- 9.3) for disruptive disorders; 2% (1.3- 3.1) for bipolar disorders; 2.7% (1.8- 4.2) for depression; 1.8% (0.4–8.7) for obsessive-compulsive disorder; and 0.6% (0.3–1.1) for psychosis. Psychiatric comorbidity in population-based studies is lower than in clinical and referred samples. However, our results also indicate that the frequency of psychiatric comorbidity in children and adolescents with ASD in the population context is considerable, without the influence of referral bias implicit in clinical and treatment samples. There is a need for better targeted diagnostic tools to detect psychiatric comorbidity in children and youth in future population-based studies, as an essential component in providing care as well as new insights into the nature and mechanisms of its underlying associations.

Systematic Review Registration

[https://www.crd.york.ac.uk/prospero/], identifier [CRD42021234464].
Subjects With Diabetes Mellitus Are at Increased Risk for Developing Tuberculosis: A Cohort Study in an Inner-City District of Barcelona (Spain)
Authors: Antonio-Arques Violeta , Franch-Nadal Josep , Moreno-Martinez Antonio , Real Jordi , Orcau Àngels , Mauricio Didac , Mata-Cases Manel , Julve Josep , Navas Mendez Elena , Puig Treserra Rai , Barrot de la Puente Joan , Millet Joan Pau , Del Val García Jose Luis , Vlacho Bogdan , Caylà Joan A.
Published: May 2022

Background

Tuberculosis is the leading cause of mortality from lung infectious disease worldwide in recent years, and its incidence has re-emerged in large cities in low-incidence countries due to migration and socioeconomic deprivation causes. Diabetes mellitus and tuberculosis are syndemic diseases, with diabetes being considered a risk factor for developing tuberculosis.

Objective

To investigate whether diabetic patients were at increased risk of tuberculosis living in an inner-district of a large city of northeastern Spain.

Methods

Observational matched retrospective cohort study based on clinical records from the population of the lowest socioeconomic status in Barcelona (Ciutat Vella district). A cohort including patients with type 1 and type 2 diabetes mellitus in 2007 and new cases until 2016 (8004 subjects), matched 1:1 by sex and age with a non-diabetic cohort. Follow-up period was until December 31st 2018. We evaluated the risk of developing tuberculosis in diabetic patients compared to non-diabetic patients during the follow up period. We used time-to-event analysis to estimate the incidence of tuberculosis, and competing risks regression by clusters and conditional Cox regression models to calculate the hazard ratio (HR) and its 95% confidence intervals (CI).

Results

Among the 16,008 included subjects, the median follow-up was 8.7 years. The mean age was 57.7 years; 61.2% men and 38.8% women in both groups. The incidence of tuberculosis was 69.9 per 100,000 person-years in diabetic patients, and 40.9 per 100,000 person-years in non-diabetic patients (HR = 1.90; CI: 1.18–3.07). After adjustment for the country of origin, chronic kidney disease, number of medical appointments, BMI, alcoholism and smoking, the risk remained higher in diabetic patients (1.66: CI 0.99–2.77). Additionally, subjects from Hindustan or with a history of alcohol abuse also showed a higher risk of developing tuberculosis (HR = 3.51; CI:1.87–6.57, and HR = 2.73; CI:1.22–6.12 respectively).

Conclusion

People with diabetes mellitus were at higher risk of developing tuberculosis in a large cohort recruited in an inner-city district with a high incidence for this outcome, and low socioeconomic conditions and high proportion of migrants. This risk was higher among Hindustan born and alcohol abusers.
Multi-Epitope Protein as a Tool of Serological Diagnostic Development for HTLV-1 and HTLV-2 Infections
Authors: Franco Gabriela de Melo , Rocha Anderson Santos da , Cox Laura Jorge , Daian e Silva Danielle Soares de Oliveira , da Silveira e Santos Débora Marques , Martins Marina Lobato , Romanelli Luis Claudio , Ishak Ricardo , Vallinoto Antonio C. R. , Bomfim Maria Rosa Q. , Caterino-de-Araujo Adele , Coelho-dos-Reis Jordana G. A. , da Fonseca Flávio Guimarães , Barbosa-Stancioli Edel Figueiredo
Published: May 2022

A multi-epitope protein expressed in a prokaryotic system, including epitopes of Env, Gag, and Tax proteins of both HTLV-1 and HTLV-2 was characterized for HTLV-1/2 serological screening. This tool can contribute to support the implementation of public policies to reduce HTLV-1/2 transmission in Brazil, the country with the highest absolute numbers of HTLV-1/2 infected individuals. The chimeric protein was tested in EIA using serum/plasma of HTLV-infected individuals and non-infected ones from four Brazilian states, including the North and Northeast regions (that present high prevalence of HTLV-1/2) and Southeast region (that presents intermediate prevalence rates) depicting different epidemiological context of HTLV-1/2 infection in our country. We enrolled samples from Pará (n = 114), Maranhão (n = 153), Minas Gerais (n = 225) and São Paulo (n = 59) states; they are from blood donors' candidates (Pará and Minas Gerais), pregnant women (Maranhão) and HIV+/high risk for sexually transmitted infection (STI; São Paulo). Among the HTLV-1/2 positive sera, there were co-infections with viral (HTLV-1 + HTLV-2, HIV, HCV, and HBV), bacterial (Treponema pallidum) and parasitic (Trypanosoma cruzi, Schistosma mansoni, Strongyloides stercoralis, Entamoeba coli, E. histolytica, and Endolimax nana) pathogens related to HTLV-1/2 co-morbidities that can contribute to inconclusive diagnostic results. Sera positive for HIV were included among the HTLV-1/2 negative samples. Considering both HTLV-1 and HTLV-2-infected samples from all states and different groups (blood donor candidates, pregnant women, and individuals with high risk for STI), mono or co-infected and HTLV-/HIV+, the test specificity ranged from 90.09 to 95.19% and the sensitivity from 82.41 to 92.36% with high accuracy (ROC AUC = 0.9552). This multi-epitope protein showed great potential to be used in serological screening of HTLV-1 and HTLV-2 in different platforms, even taking into account the great regional variation and different profile of HTLV-1 and HTLV-2 mono or co-infected individuals.
A Music-Therapy Robotic Platform for Children With Autism: A Pilot Study
Authors: Feng Huanghao , Mahoor Mohammad H. , Dino Francesca
Published: May 2022

Children with Autism Spectrum Disorder (ASD) experience deficits in verbal and nonverbal communication skills including motor control, turn-taking, and emotion recognition. Innovative technology, such as socially assistive robots, has shown to be a viable method for Autism therapy. This paper presents a novel robot-based music-therapy platform for modeling and improving the social responses and behaviors of children with ASD. Our autonomous social interactive system consists of three modules. Module one provides an autonomous initiative positioning system for the robot, NAO, to properly localize and play the instrument (Xylophone) using the robot’s arms. Module two allows NAO to play customized songs composed by individuals. Module three provides a real-life music therapy experience to the users. We adopted Short-time Fourier Transform and Levenshtein distance to fulfill the design requirements: 1) “music detection” and 2) “smart scoring and feedback”, which allows NAO to understand music and provide additional practice and oral feedback to the users as applicable. We designed and implemented six Human-Robot-Interaction (HRI) sessions including four intervention sessions. Nine children with ASD and seven Typically Developing participated in a total of fifty HRI experimental sessions. Using our platform, we collected and analyzed data on social behavioral changes and emotion recognition using Electrodermal Activity (EDA) signals. The results of our experiments demonstrate most of the participants were able to complete motor control tasks with 70% accuracy. Six out of the nine ASD participants showed stable turn-taking behavior when playing music. The results of automated emotion classification using Support Vector Machines illustrates that emotional arousal in the ASD group can be detected and well recognized via EDA bio-signals. In summary, the results of our data analyses, including emotion classification using EDA signals, indicate that the proposed robot-music based therapy platform is an attractive and promising assistive tool to facilitate the improvement of fine motor control and turn-taking skills in children with ASD.
The United States Urban Hierarchy: An Update
Authors: Griffith Daniel A.
Published: May 2022

The sole well-recognized United States (US) urban hierarchy articulation essentially is outdated, even though selected recent work seeks to upgrade it. The primary goal of this paper is to update it in a definitive and comprehensive fashion. This paper describes the conceptual framework underlying such observed orderings, itemizes certain strengths and weaknesses of the existing articulation, and then posits a justifiable renovated US urban hierarchy. Next, recapped analyses expose both contiguity and urban hierarchy spatial autocorrelation components of the upper tiers of the 2020 US metropolitan area population rank size distribution. Noteworthy is that these descriptions entail positive-negative spatial autocorrelation mixtures. Inventoried output from the research efforts leading to this paper includes: a contemporary US urban hierarchy articulation that should prove serviceable for at least the next few decades; and, an apparatus providing a practical contribution for improving cultural, environmental, and social aspects of systems of cities through, for example, better cost containment and more efficient/effective delivery of urban public health services and utilization/consumption. The Earth's scientists need this category of tool to incorporate into methodology combating negative effects of globalization that materialize via spatial diffusion.
Activity Spaces and Big Data Sources in Segregation Research: A Methodological Review
Authors: Müürisepp Kerli , Järv Olle , Tammaru Tiit , Toivonen Tuuli
Published: May 2022

The activity space approach is increasingly mobilized in spatial segregation research to broaden its scope from residential neighborhoods to other socio-spatial contexts of people. Activity space segregation research is an emerging field, characterized by quick adaptation of novel data sources and interdisciplinary methodologies. In this article, we present a methodological review of activity space segregation research by identifying approaches, methods and data sources applied. First, our review highlights that the activity space approach enables segregation to be studied from the perspectives of people, places and mobility flows. Second, the results reveal that both traditional data sources and novel big data sources are valuable for studying activity space segregation. While traditional sources provide rich background information on people for examining the social dimension of segregation, big data sources bring opportunities to address temporality, and increase the spatial extent and resolution of analysis. Hence, big data sources have an important role in mediating the conceptual change from a residential neighborhood-based to an activity space-based approach to segregation. Still, scholars should address carefully the challenges and uncertainties that big data entail for segregation studies. Finally, we propose a framework for a three-step methodological workflow for activity space segregation analysis, and outline future research avenues to move toward more conceptual clarity, integrated analysis framework and methodological rigor.
Are Eggs a Superpower for the Brain and Memory?
Authors: Ylilauri Maija P. T. , Virtanen Jyrki K.
Published: May 2022

When you and your friends get old, gray, and wrinkly, it is likely that some of you will end up having memory problems. The most common illness of the memory is called Alzheimer’s disease. Alzheimer’s causes difficulties with remembering the names of your friends, the jokes that were just told, or even the well-trodden way home. Sounds awful, right? As there is currently no cure for Alzheimer’s disease, researchers are trying hard to find ways to prevent it. A healthy diet may be one approach. This article describes the potential link between eating eggs and the chance of having memory problems later in life. Maybe you are wondering how on Earth eggs and memory are connected. That is a good question! Please keep reading to find out whether eggs have superpowers for your brain and memory.
An Antarctic Alga That Can Survive The Extreme Cold
Authors: Smith David R. , Leung Arthur , Zhang Xi , Cvetkovska Marina , Morgan-Kiss Rachael , Hüner Norman P. A.
Published: May 2022

Microscopic algae are tougher than you might think. Some can even survive the extreme cold. In this article, we describe one of the coolest algae of all, the Antarctic green alga called Chlamydomonas sp. UWO241. This one-celled super-organism lives deep in the frigid waters of a remote and permanently ice-covered lake in Antarctica. How does this little alga thrive in such a barren and unwelcoming place? Well, dive into this article to learn how studying the genome of UWO241 is helping scientists better understand this amazingly hardy alga.
Optimization of an Intermittent Finger Endurance Test for Climbers Regarding Gender and Deviation in Force and Pulling Time
Authors: Augste Claudia , Winkler Marvin , Künzell Stefan
Published: May 2022

Performance diagnostics of finger strength is very relevant in climbing. The aim of our study was to find modalities for an intermittent finger flexor muscle endurance test that optimize the correlation of test performance with lead climbing performance. Twenty-seven female and 25 male climbers pulled with 60% MVC and a work-to-rest ratio of 7:2 s on a fingerboard until fatigue. The highest correlations, R = 0.429, were found for women when 9% deviation in the required force and 1 s deviation in the required pulling time was tolerated. For men, the optimum was reached with the same time deviation and a force deviation of 6%, R = 0.691. Together with maximum finger strength the repetitions explained 31.5% of the variance of climbing ability in women and 46.3% in men. Consequences from our results are to tolerate at least 7% force deviation for women and 5% for men and to terminate the finger endurance test quickly after the force falls below the threshold.