bluuebunny/crossref_metadata_2025 huggingface dataset:
The development of a four-tier test to evaluate research integrity training
Authors: Zollitsch Linda , Wilder Nicolaus , Priess-Buchheit Julia
Published: August 2021

Although higher education institutions across Europe and beyond are paying more and more attention to research integrity training, there are few studies and little evidence on what works and what does not work in such training. One way to overcome this challenge is to evaluate such training with standardised instruments. Experts/trainers have used qualitative approaches to evaluate their research integrity training's successes, but it is difficult to compare their results with others. Sometimes they conduct standardised tests drawn from ethics education or other related fields, but these tests do not assess research integrity's core themes. At present, there is a lack of standardised instruments designed to specifically evaluate success in research integrity training. This article presents a pre-validated instrument for this purpose. Named the P2I questionnaire, it is designed as a four-tier test and based on the European Code of Conduct for Research Integrity; in it, testees choose a (scientific) practice to address an issue, justify their decision, and describe how confident they are with their decisions. The development of the P2I questionnaire is outlined in three steps. After describing the research integrity (alternatively, the responsible conduct of research) training successes, the article notes scientific and non-scientific patterns and then concludes with a pre-validated and revised version of the P2I questionnaire. This questionnaire is intended as a first step in a discourse on standardised research integrity measurements and is one step towards an evidence-based improvement of research integrity training.
Tissue-dependent transcriptional and bacterial associations in primary sclerosing cholangitis-associated inflammatory bowel disease
Authors: Ilott Nicholas E. , Neyazi Mastura ,   Oxford Translational Gastroenterology Unit Investigators, Arancibia-Cárcamo Carolina V. , Powrie Fiona , Geremia Alessandra
Published: August 2021

Background: Primary sclerosing cholangitis (PSC) is a disease of the bile duct and liver. However, patients frequently have co-morbidities including inflammatory bowel disease (IBD) and colorectal cancer. Colorectal cancer risk in patients with PSC-associated ulcerative colitis (PSC/UC) is elevated relative to patients with ulcerative colitis (UC) alone, reasons for which remain obscure. Further, clinical and immunological features, and involved intestinal sites differ between PSC/UC and UC. Understanding the molecular and microbial basis for differences in cancer risk between these two patient groups and how these differ across intestinal sites is important for the development of therapies to prevent colorectal cancer development in at-risk individuals.  

Methods: We employed ribonucleic acid sequencing (RNA-seq) analysis of biopsy samples across three intestinal tissue locations (ileum, caecum and rectum) in patients with PSC/UC (n = 8), UC (n = 10) and healthy controls (n = 12) to determine tissue-dependent transcriptional alterations in PSC/UC. We also performed 16S ribosomal RNA (rRNA) amplicon sequencing to determine bacterial associations with PSC/UC and host-microbiome associations.

Results: Tissue-defining transcriptional signatures revealed that the ileum was enriched for genes involved in lipid and drug metabolism, the caecum for activated immune cells and the rectum for enteric neurogenesis. Transcriptional alterations relative to healthy control samples were largely shared between patients with PSC/UC or UC although were distinct across tissue locations. Nevertheless, we observed reduced expression of gamma-glutamyl transferase 1 (GGT1) specifically in the ileum and caecum of patients with PSC/UC.

Analysis of the bacterial component of the microbiome revealed high inter-individual variability of microbiome composition and little evidence for tissue-dependency. We observed a reduction in Parabacteroides relative abundance in the rectum of patients with PSC/UC.

Conclusions: The role of gamma-glutamyl transferase in maintaining the redox environment through the glutathione salvage pathway makes our observed alterations a potential pathway to PSC-associated colorectal cancer.
Social media reactions of nurses to the documentary Stacey Dooley: On the Psych Ward
Authors: Porter Cody Normitta
Published: August 2021

Background/Aims

Mental health nursing is becoming a more transparent discipline. Increasingly, documentaries have provided the general public with insights regarding these therapeutic ward environments. The opinions of staff working in such places is important for ensuring the accuracy of the information, and the usefulness of what is publicly aired. This study explored the social media comments of nursing staff (as the experts) who viewed the Stacey Dooley: On the Psych Ward documentary.

Methods

Social media (Facebook and Twitter) were searched for comments on the documentary 3 weeks after the documentary was aired. In total, 4008 Facebook comments and 604 tweets were downloaded and assessed. Comments that did not relate to the documentary were excluded. A total of 31 Facebook comments and 54 tweets were used for analysis.

Results

Some evidence of criticism towards the presenter was found, as well as the use of an award-winning hospital as a non-representative – and unrealistic – example of psychiatric care. In general, healthcare staff felt that the documentary was useful for informing the general public, as well as students.

Conclusions

Documentaries such as this one that capture the realities of working on mental health wards have educational merit.
Personalised care in maternity
Authors: Winfield Sarah , Booker Maria
Published: August 2021

Although COVID-19 has placed immense pressure on healthcare professionals, Dr Sarah Winfield and Maria Booker still believe personalised care is the utmost of importance in maternity services
Nonparallel flat portions on the boundaries of numerical ranges of 4-by-4 nilpotent matrices
Authors: Cox Mackenzie , Grewe Weston , Hochrein Grace , Patton Linda , Spitkovsky Ilya
Published: August 2021

The 4-by-4 nilpotent matrices whose numerical ranges have nonparallel flat portions on their boundary that are on lines equidistant from the origin are characterized. Their numerical ranges are always symmetric about a line through the origin and all possible angles between the lines containing the flat portions are attained.
Temporal characterization of electron dynamics in attosecond XUV and infrared laser fields
Authors: Guo Li , Jia Yi , Liu Mingqing , Jia Xinyan , Hu Shilin , Lu Ronghua , Han ShenSheng , Chen Jing
Published: August 2021

We use a Wigner distribution-like function based on the strong field approximation theory to obtain the time-energy distributions and the ionization time distributions of electrons ionized by an XUV pulse alone and in the presence of an infrared (IR) pulse. In the case of a single XUV pulse, although the overall shape of the ionization time distribution resembles the XUV-envelope, its detail shows dependence on the emission direction of the electron and the carrier-envelope phase of the pulse, which mainly results from the low-energy interference structure. It is further found that the electron from the counter-rotating term plays an important role in the interference. In the case of the two-color pulse, both the time-energy distributions and the ionization time distributions change with varying IR field. Our analysis demonstrates that the IR field not only modifies the final electron kinetic energy but also changes the electron’s emission time, which is attributed to the change of the electric field induced by the IR pulse. Moreover, the ionization time distributions of the photoelectrons emitted from atoms with higher ionization energy are also given, which show less impact of the IR field on the electron dynamics.
Fast HDR image generation method from a single snapshot image based on frequency division multiplexing technology
Authors: Niu Bin , Qu Xinghua , Guan Xiaomei , Zhang Fumin
Published: August 2021

Traditional high dynamic range (HDR) image generation algorithms such as multi-exposure fusion need to capture multiple images for algorithm fusion, which is not only slow but also occupies a lot of storage space, which limits the application of multi-exposure fusion technology. In this paper, the frequency division multiplexing method is used to separate the sub-images with different exposure values from a single snapshot image successfully. The resolution of HDR images generated by this method is almost the same as that of the traditional multiple exposure methods, the storage space is greatly reduced and the imaging speed is improved.
Compressive ultrafast pulse measurement via time-domain single-pixel imaging
Authors: Zhao Jiapeng , Dai Jianming , Braverman Boris , Zhang Xi-Cheng , Boyd Robert W.
Published: August 2021

In contrast to imaging using position-resolving cameras, single-pixel imaging uses a bucket detector along with spatially structured illumination to compressively recover images. This emerging imaging technique is a promising candidate for a broad range of applications due to the high signal-to-noise ratio (SNR) and sensitivity, and applicability in a wide range of frequency bands. Here, inspired by single-pixel imaging in the spatial domain, we demonstrate a time-domain single-pixel imaging (TSPI) system that covers frequency bands including both terahertz (THz) and near-infrared (NIR) regions. By implementing a programmable temporal fan-out gate based on a digital micromirror device, we can deterministically prepare temporally structured pulses with a temporal sampling size down to

16.00
±
0.01

f
s

. By inheriting the advantages of detection efficiency and sensitivity from spatial single-pixel imaging, TSPI enables the recovery of a 5 fJ THz pulse and two NIR pulses with over

97
%

fidelity via compressive sensing. We demonstrate that the TSPI is robust against temporal distortions in the probe pulse train as well. As a direct application, we apply TSPI to machine-learning-aided THz spectroscopy and demonstrate a high sample identification accuracy (97.5%) even under low SNRs (SNR

∼

10

).
Deep geometric representations for modeling effects of mutations on protein-protein binding affinity
Authors: Liu Xianggen , Luo Yunan , Li Pengyong , Song Sen , Peng Jian
Published: August 2021

Modeling the impact of amino acid mutations on protein-protein interaction plays a crucial role in protein engineering and drug design. In this study, we develop GeoPPI, a novel structure-based deep-learning framework to predict the change of binding affinity upon mutations. Based on the three-dimensional structure of a protein, GeoPPI first learns a geometric representation that encodes topology features of the protein structure via a self-supervised learning scheme. These representations are then used as features for training gradient-boosting trees to predict the changes of protein-protein binding affinity upon mutations. We find that GeoPPI is able to learn meaningful features that characterize interactions between atoms in protein structures. In addition, through extensive experiments, we show that GeoPPI achieves new state-of-the-art performance in predicting the binding affinity changes upon both single- and multi-point mutations on six benchmark datasets. Moreover, we show that GeoPPI can accurately estimate the difference of binding affinities between a few recently identified SARS-CoV-2 antibodies and the receptor-binding domain (RBD) of the S protein. These results demonstrate the potential of GeoPPI as a powerful and useful computational tool in protein design and engineering. Our code and datasets are available at: https://github.com/Liuxg16/GeoPPI.
Application of telemedicine in the COVID-19 epidemic: An analysis of Gansu Province in China
Authors: Wang Yan , Yang Jie , Ma Huijuan , Dong Xinchun , Xie Guangmei , Ye Songning , Du Juan
Published: August 2021

This paper analyzes the application of various telemedicine services in Gansu Province, China during the COVID-19 epidemic, and summarizes the experiences with these services. In addition, the satisfaction levels of patients and doctors with the application of telemedicine in COVID-19 were investigated, the deficiencies of telemedicine in Gansu were determined, and recommendations for modification were proposed. Coronavirus Disease 2019 (COVID-19) has broken out in China, and Gansu Province in Northwest of China has not been spared. To date, there are 91 local COVID-19 cases and 42 imported cases. 109 hospitals were selected as designated hospitals during the COVID-19 outbreak, and most of them were secondary hospitals. However, it was unsatisfactory that the ability of medical services is relatively low in most of secondary hospitals and primary hospitals. Therefore, we helped the secondary hospitals cope with COVID-19 by means of remote consultation, long-distance education, telemedicine question and answer (Q&A). Our practical experience shows that telemedicine can be widely used during the COVID-19 epidemic, especially in developing countries and areas with lagging medical standards.
Clinical and biological clusters of sepsis patients using hierarchical clustering
Authors: Papin Grégory , Bailly Sébastien , Dupuis Claire , Ruckly Stéphane , Gainnier Marc , Argaud Laurent , Azoulay Elie , Adrie Christophe , Souweine Bertrand , Goldgran-Toledano Dany , Marcotte Guillaume , Gros Antoine , Reignier Jean , Mourvillier Bruno , Forel Jean-Marie , Sonneville Romain , Dumenil Anne-Sylvie , Darmon Michael , Garrouste-Orgeas Maité , Schwebel Carole , Timsit Jean-François ,   OUTCOMEREA study group
Published: August 2021

Background

Heterogeneity in sepsis expression is multidimensional, including highly disparate data such as the underlying disorders, infection source, causative micro-organismsand organ failures. The aim of the study is to identify clusters of patients based on clinical and biological characteristic available at patients’ admission.

Methods

All patients included in a national prospective multicenter ICU cohort OUTCOMEREA and admitted for sepsis or septic shock (Sepsis 3.0 definition) were retrospectively analyzed. A hierarchical clustering was performed in a training set of patients to build clusters based on a comprehensive set of clinical and biological characteristics available at ICU admission. Clusters were described, and the 28-day, 90-day, and one-year mortality were compared with log-rank rates. Risks of mortality were also compared after adjustment on SOFA score and year of ICU admission.

Results

Of the 6,046 patients with sepsis in the cohort, 4,050 (67%) were randomly allocated to the training set. Six distinct clusters were identified: young patients without any comorbidities, admitted in ICU for community-acquired pneumonia (n = 1,603 (40%)); young patients without any comorbidities, admitted in ICU for meningitis or encephalitis (n = 149 (4%)); elderly patients with COPD, admitted in ICU for bronchial infection with few organ failures (n = 243 (6%)); elderly patients, with several comorbidities and organ failures (n = 1,094 (27%)); patients admitted after surgery, with a nosocomial infection (n = 623 (15%)); young patients with immunosuppressive conditions (e.g., AIDS, chronic steroid therapy or hematological malignancy) (n = 338 (8%)). Clusters differed significantly in early or late mortality (p < .001), even after adjustment on severity of organ dysfunctions (SOFA) and year of ICU admission.

Conclusions

Clinical and biological features commonly available at ICU admission of patients with sepsis or septic shock enabled to set up six clusters of patients, with very distinct outcomes. Considering these clusters may improve the care management and the homogeneity of patients in future studies.
Socioeconomic position, social mobility, and health selection effects on allostatic load in the United States
Authors: Gugushvili Alexi , Bulczak Grzegorz , Zelinska Olga , Koltai Jonathan
Published: August 2021

The contemporaneous association between higher socioeconomic position and better health is well established. Life course research has also demonstrated a lasting effect of childhood socioeconomic conditions on adult health and well-being. Yet, little is known about the separate health effects of intergenerational mobility—moving into a different socioeconomic position than one’s parents—among early adults in the United States. Most studies on the health implications of mobility rely on cross-sectional datasets, which makes it impossible to differentiate between health selection and social causation effects. In addition, understanding the effects of social mobility on health at a relatively young age has been hampered by the paucity of health measures that reliably predict disease onset. Analysing 4,713 respondents aged 25 to 32 from the National Longitudinal Study of Adolescent Health’s Waves I and IV, we use diagonal reference models to separately identify the effects of socioeconomic origin and destination, as well as social mobility on allostatic load among individuals in the United States. Using a combined measure of educational and occupational attainment, and accounting for individuals’ initial health, we demonstrate that in addition to health gradient among the socially immobile, individuals’ socioeconomic origin and destination are equally important for multi-system physiological dysregulation. Short-range upward mobility also has a positive and significant association with health. After mitigating health selection concerns in our observational data, this effect is observed only among those reporting poor health before experiencing social mobility. Our findings move towards the reconciliation of two theoretical perspectives, confirming the positive effect of upward mobility as predicted by the “rags to riches” perspective, while not contradicting potential costs associated with more extensive upward mobility experiences as predicted by the dissociative thesis.
Community daytime noise pollution and socioeconomic differences in Chicago, IL
Authors: Huang Yu-Kai , Mitchell Uchechi A. , Conroy Lorraine M. , Jones Rachael M.
Published: August 2021

Environmental noise may affect hearing and a variety of non-auditory disease processes. There is some evidence that, like other environmental hazards, noise may be differentially distributed across communities based on socioeconomic status. We aimed to a) predict daytime noise pollution levels and b) assess disparities in daytime noise exposure in Chicago, Illinois. We measured 5-minute daytime noise levels (Leq, 5-min) at 75 randomly selected sites in Chicago in March, 2019. Geographically-based variables thought to be associated with noise were obtained, and used to fit a noise land-use regression model to estimate the daytime environmental noise level at the centroid of the census blocks. Demographic and socioeconomic data were obtained from the City of Chicago for the 77 community areas, and associations with daytime noise levels were assessed using spatial autoregressive models. Mean sampled noise level (Leq, 5-min) was 60.6 dBA. The adjusted R2 and root mean square error of the noise land use regression model and the validation model were 0.60 and 4.67 dBA and 0.51 and 5.90 dBA, respectively. Nearly 75% of city blocks and 85% of city communities have predicted daytime noise level higher than 55 dBA. Of the socioeconomic variables explored, only community per capita income was associated with mean community predicted noise levels, and was highest for communities with incomes in the 2nd quartile. Both the noise measurements and land-use regression modeling demonstrate that Chicago has levels of environmental noise likely contributing to the total burden of environmental stressors. Noise is not uniformly distributed across Chicago; it is associated with proximity to roads and public transportation, and is higher among communities with mid-to-low incomes per capita, which highlights how socially and economically disadvantaged communities may be disproportionately impacted by this environmental exposure.
Assessing the healthiness of UK food companies’ product portfolios using food sales and nutrient composition data
Authors: Bandy Lauren Kate , Hollowell Sven , Harrington Richard , Scarborough Peter , Jebb Susan , Rayner Mike
Published: August 2021

Background

The provision and over-consumption of foods high in energy, saturated fat, free sugars or salt are important risk factors for poor diet and ill-health. In the UK, policies seek to drive improvement through voluntary reformulation of single nutrients in key food groups. There has been little consideration of the overall progress by individual companies. This study assesses recent changes in the nutrient profile of brands and products sold by the top 10 food and beverage companies in the UK.

Methods

The FSA/Ofcom nutrient profile model was applied to the nutrient composition data for all products manufactured by the top 10 food and beverage companies and weighted by volume sales. The mean nutrient profiling score, on a scale of 1–100 with thresholds for healthy products being 62 for foods and 68 for drinks, was used to rank companies and food categories between 2015 and 2018, and to calculate the proportion of individual products and sales that are considered by the UK Government to be healthy.

Results

Between 2015 and 2018 there was little change in the sales-weighted nutrient profiling score of the top 10 companies (49 to 51; p = 0.28) or the proportion of products classified as healthy (46% to 48%; p = 0.23). Of the top five brands sold by each of the ten companies, only six brands among ten companies improved their nutrient profiling score by 20% or more. The proportion of total volume sales classified as healthy increased from 44% to 51% (p = 0.07) driven by an increase in the volume sales of bottled water, low/no calorie carbonates and juices, but after removing soft drinks, the proportion of foods classified as healthy decreased from 7% to 6% (p = 33).

Conclusions

The UK voluntary reformulation policies, setting targets for reductions in calories, sugar and salt, do not appear to have led to significant changes in the nutritional quality of foods, though there has been progress in soft drinks where the soft drink industry levy also applies. Further policy action is needed to incentivise companies to make more substantive changes in product composition to support consumers to achieve a healthier diet.
Which determinants should be considered to reduce social inequalities in paediatric dental care access? A cross-sectional study in France
Authors: Marquillier Thomas , Trentesaux Thomas , Pierache Adeline , Delfosse Caroline , Lombrail Pierre , Azogui-Levy Sylvie
Published: August 2021

Better access to dental care through systemic and educational strategies is needed to lessen the burden of disease due to severe early caries. Our study aims to describe family characteristics associated with severe early caries: parental knowledge, attitudes, practices in oral health and socio-demographic factors. For this cross-sectional study, 102 parents of children aged under 6 years with severe early caries and attending paediatric dentistry service in France completed a questionnaire during face-to-face interviews. Caries were diagnosed clinically by calibrated investigators, using the American Academy of Paediatric Dentistry criteria, and dental status was recorded using the decayed, missing, and filled teeth index. The majority of children were from underprivileged backgrounds and had poor oral health status, with a median dmft index of 10. Parents highlighted the difficulty of finding suitable dental care in private practices. Parents appeared to have good oral health knowledge and engaged in adapted behaviours but showed a low sense of self-efficacy. They perceived the severity of early caries as important but the susceptibility of their child as moderate. The study affirmed the importance of improving the accessibility of paediatric dental care and developing educational strategies to enhance the knowledge, skills, and oral health practices of families.
Tissue block staining and domestic adhesive tape yield qualified integral sections of adult mouse orbits and eyeballs
Authors: Li Zhongmin , Ungerer Martin , Faßbender Julia , Wenhart Clara , Holthoff Hans-Peter , Muench Goetz
Published: August 2021

The standard histological processing procedure, which produces excellent staining of sections for most tissues, fails to yield satisfactory results in adult mouse orbits or eyeballs. Here, we show that a protocol using tissue block staining and domestic adhesive tapes resulted in qualified integral serial cryo-sections of whole orbits or eyeballs, and the fine structures were well preserved. The histological processing protocol comprises paraformaldehyde fixation, ethylenediaminetetraacetic acid decalcification, tissue block staining with hematoxylin and eosin, embedding, adhesive tape aided sectioning, and water-soluble mounting. This protocol was proved to be the best in comparison with seven other related existing histological traditional or non-traditional processing methods, according to the staining slice quality. We observed a hundred percent success rate in sectioning, collection, and mounting with this method. The reproducibility tested on qualified section success rates and slice quality scores confirmed that the technique is reliable. The feasibility of the method to detect target molecules in orbits was verified by successful trial tests on block immunostaining and adhesive tape-aided sectioning. Application of this protocol in joints, brains, and so on,—the challenging integral sectioning tissues, also generated high-quality histological staining sections.
Initiation of domiciliary care and nursing home admission following first hospitalization for heart failure, stroke, chronic obstructive pulmonary disease or cancer
Authors: Rørth Rasmus , Clausen Marianne F. , Fosbøl Emil L. , Mogensen Ulrik M. , Kragholm Kristian , Jhund Pardeep S. , Petrie Mark C. , Torp-Pedersen Christian , Gislason Gunnar H. , McMurray John J. V. , Køber Lars , Kristensen Søren L.
Published: August 2021

Background

Patients with chronic diseases are at higher risk of requiring domiciliary and nursing home care, but how different chronic diseases compare in terms of risk is not known. We examined initiation of domiciliary care and nursing home admission among patients with heart failure (HF), stroke, COPD and cancer.

Methods

Patients with a first-time hospitalization for HF, stroke, COPD or cancer from 2008–2016 were identified. Patients were matched on age and sex and followed for five years.

Results

111,144 patients, 27,786 with each disease, were identified. The median age was 69 years and two thirds of the patients were men. The 5-year risk of receiving domiciliary care was; HF 20.9%, stroke 25.2%, COPD 24.6% and cancer 19.3%. The corresponding adjusted hazard ratios (HRs), with HF patients used as reference, were: stroke 1.35[1.30–1.40]; COPD 1.29[1.25–1.34]; and cancer 1.19[1.14–1.23]. The five-year incidence of nursing home admission was 6.6% for stroke, and substantially lower in patients with HF(2.6%), COPD(2.6%) and cancer (1.5%). The adjusted HRs were (HF reference): stroke, 2.44 [2.23–2.68]; COPD 1.01 [0.91–1.13] and cancer 0.76 [0.67–0.86]. Living alone, older age, diabetes, chronic kidney disease, depression and dementia predicted a higher likelihood of both types of care.

Conclusions

In patients with HF, stroke, COPD or cancer 5-year risk of domiciliary care and nursing home admission, ranged from 19–25% and 1–7%, respectively. Patients with stroke had the highest rate of domiciliary care and were more than twice as likely to be admitted to a nursing home, compared to patients with the other conditions.
Community’s experience and perceptions of maternal health services across the continuum of care in Ethiopia: A qualitative study
Authors: Tiruneh Gizachew Tadele , Demissie Meaza , Worku Alemayehu , Berhane Yemane
Published: August 2021

Background

Continuum of care is an effective strategy to ensure that every woman receives a series of maternal health services continuously from early pregnancy to postpartum stages. The community perceptions regarding the use of maternal services across the continuum of care are essential for utilization of care in low-income settings but information in that regard is scanty. This study explored the community perceptions on the continuum of care for maternal health services in Ethiopia.

Methods

This study employed a phenomenological qualitative research approach. Four focus group discussions involving 26 participants and eight in-depth interviews were conducted with women who recently delivered, community health workers, and community leaders that were purposively selected for the study in West Gojjam zone, Amhara region. All the interviews and discussions were audio-taped; the records were transcribed verbatim. Data were coded and analyzed thematically using ATLAS.ti software.

Results

We identified three primary themes: practice of maternal health services; factors influencing the decision to use maternal health services; and reasons for discontinuation across the continuum of maternal health services. The study showed that women faced multiple challenges to continuously uptake maternal health services. Late antenatal care booking was the main reasons for discontinuation of maternal health services across the continuum at the antepartum stage. Women’s negative experiences during care including poor quality of care, incompetent and unfriendly health providers, disrespectful care, high opportunity costs, difficulties in getting transportation, and timely referrals at healthcare facilities, particularly at health centers affect utilization of maternal health services across the continuum of care. In addition to the reverberation effect of the intrapartum care factors, the major reasons mentioned for discontinuation at the postpartum stage were lack of awareness about postnatal care and service delivery modality where women are not scheduled for postpartum consultations.

Conclusion

This study showed that rural mothers still face multiple challenges to utilize maternal health services as recommended by the national guidelines. Negative experiences women encountered in health facilities, community perceptions about postnatal care services as well as challenges related to service access and opportunity costs remained fundamental to be reasons for discontinuation across the continuum pathways.
Magnetic and electric field accelerate Phytoextraction of copper Lemna minor duckweed
Authors: Politaeva Natalia , Badenko Vladimir
Published: August 2021

In accordance with the opinion of the World Health Organization and the World Water Council the development of effective technologies for the treatment of wastewater from heavy metals for their discharge into water bodies or reuse is an urgent task nowadays. Phytoremediation biotechnologies is the most environmentally friendly and cheapest way of the treatment of wastewater, suitable for sustainable development principals. The main disadvantage of the phytoremediation is the slow speed of the process. A method for accelerating the process of phytoremediation by the combined effect of magnetic and weak electric fields is proposed. The purpose of this study is to determine the values of the parameters of the magnetic and weak electric fields that are most suitable for extracting cuprum ions from wastewater using the higher aqua plants (Lemna minor). A corresponding technological process based on the results of the study is proposed. The results have shown that the removal of copper cations from sulfate solutions effectively occurs in the initial period of time (1–5 hours) under the influence of a magnetic field with an intensity ofH= 2 kA/m. Under the combined influence of an electrical current with densityj= 240 μA/cm2and a magnetic field (H= 2 kA/m) the highest rate of copper extraction by duckweed leaves is achieved. Under these conditions, the greatest growth and development of plant leaves occurs. The paper presents the results of determining of the parameters of the electrochemical release from the eluate of the spent phytomass of duckweed. It has been determined that the release of metal occurs atE= 0.32 V. An original scheme for wastewater treatment from copper with subsequent separation of copper from the spent phytomass of duckweed is proposed. In general, the presented results are a scientific justification of wastewater treatment technologies and a contribution to resolving the crisis in the field of fresh water supply. An important contribution in the circular economy is a technology recommendation proposed for recovering copper from duckweed after wastewater treatment.
Application of manual aspiration thrombectomy in the treatment of deep vein thrombosis in cancer patients: Descriptive retrospective cohort study
Authors: Kim Eu Hyun , Lee Hae Giu , Oh Jung Suk , Chun Ho Jong , Choi Byung Gil , Lee Myung Ah
Published: August 2021

Objectives

To determine the outcomes and feasibility of endovascular treatment, mainly based on manual aspiration thrombectomy (MAT) with adjunctive percutaneous balloon angioplasty with or without stent deployment, for treatment of symptomatic ilio-femoral deep vein thrombosis (IFDVT) in cancer patients.

Materials and methods

In this retrospective cohort study, 135 consecutive patients (56 men; mean age, 63 years; 149 limbs) with acute (n = 113; 83.7%) and subacute to chronic (n = 22; 16.3%) symptomatic IFDVT underwent MAT-based endovascular treatment. Among them, adjunctive balloon angioplasty and stent placement was performed in 94 patients. Technical and clinical success regarding stage and cause of DVT was assessed.

Results

Technical success (complete thrombus removal without residual thrombus or stenosis) was achieved in 89.6%, and subjective symptom improvement was stated by 71.5% of treated patients. The primary patency rates were 88.1%, 81.6%, 76.0%, 74.1% and 69.1% at 1, 3, 6, 12, and 30 months, respectively. Recurrent IFDVT occurred in 19.3% (26/135) of patients, 0.79 cases per patients-years of follow up. According to the analysis by causes of IFDVT, recurrence rate was 19.3% (11/57), 21.2% (12/57), and 14.3% (3/21) in unknown, compression/invasion of the vein by cancerous mass, and May-Thurner syndrome groups, respectively (p = 0.798). No procedure-related complication developed.

Conclusions

Endovascular treatment based on MAT is a feasible treatment option with favorable outcomes and minimal risk of complication in cancer patients with symptomatic IFDVT.
Use of online resources by undergraduate medical students at College of Medicine, Majmaah University, Kingdom of Saudi Arabia
Authors: Alabdulwahhab Khalid M. , Kazmi Syed Yousaf , Sami Waqas , Almujel Khaled Nasser , Alanazi Mohammed Hamed , Alanazi Khalid Falah , Moyana Abdullah Meshal , Ahmad Mohammad Shakil , Alasbali Tariq A. , Al Alwadani Fahd
Published: August 2021

The current pandemic has revolutionized medical education with a rapid shift to online teaching and learning strategies. The students have coped by turning to the online resources to keep pace with the change. To determine the type and practice of online resources used by undergraduate medical students and compare the use of online resources with gender and GPA. This was a cross-sectional study in which an online self-administered questionnaire was used to evaluate the type and practices of the online resources used by the medical students during the Covid-19 pandemic. Complete enumeration sampling method was used to collect the data from 180 medical students studying at College of Medicine, Majmaah University, Saudi Arabia. One hundred and thirty students (72.2%) were unaware of the free online resources offered by the University. Most students (58.3%, n = 105) consulted peers for online references. Male students preferred PowerPoint presentations and consulting online resources for studying as compared to the females, whereas females preferred to study textbooks predominantly as compared to males (p = 0.005). Male students significantly shifted to the online resources during the COVID-19 pandemic as compared to females (p = 0.028). Students with the highest GPA scores shifted to online educational resources during pandemic. A significant proportion of the undergraduate medical students at College of Medicine, Majmaah University used online educational resources for learning. We recommend that the college administration for deliberation with the medical educationalists for necessary curricular amendments and taking necessary steps to make the college Academic supervision and mentorship program more proactive to meet the challenges of students’ use of online educational resources.
Investigation of dual antiplatelet therapy after coronary stenting in patients with chronic kidney disease
Authors: Kao Chih-Chin , Wu Mai-Szu , Chuang Ming-Tsang , Lin Yi-Cheng , Huang Chun-Yao , Chang Wei-Chiao , Chen Chih-Wei , Chang Tzu-Hao
Published: August 2021

Background

Dual antiplatelet therapy (DAPT) is currently the standard treatment for the prevention of ischemic events after stent implantation. However, the optimal DAPT duration remains elusive for patients with chronic kidney disease (CKD). Therefore, we aimed to compare the effectiveness and safety between long-term and short-term DAPT after coronary stenting in patients with CKD.

Methods

This retrospective cohort study analyze data from the Taipei Medical University (TMU) Institutional and Clinical Database, which include anonymized electronic health data of 3 million patients that visited TMU Hospital, Wan Fang Hospital, and Shuang Ho Hospital. We enrolled patients with CKD after coronary stenting between 2008 and 2019. The patients were divided into the long-term (>6 months) and short-term DAPT group (≤ 6 months). The primary end point was major adverse cardiovascular events (MACE) from 6 months after the index date. The secondary outcomes were all-cause mortality and Thrombolysis in Myocardial Infarction (TIMI) bleeding.

Results

A total of 1899 patients were enrolled; of them, 1112 and 787 were assigned to the long-term and short-term DAPT groups, respectively. Long-term DAPT was associated with similar risk of MACE (HR: 1.05, 95% CI: 0.65–1.70, P = 0.83) compare with short-term DAPT. Different CKD risk did not modify the risk of MACE. There was also no significant difference in all-cause mortality (HR: 1.10, 95% CI: 0.75–1.61, P = 0.63) and TIMI bleeding (HR 1.19, 95% CI: 0.86–1.63, P = 0.30) between groups.

Conclusions

Among patients with CKD and coronary stenting, we found that long-term and short-term DAPT tied on the risk of MACE, all-cause mortality and TIMI bleeding.
Structural and quantitative alterations of gut microbiota in experimental small bowel obstruction
Authors: Mo Jiali , Gao Lei , Zhang Nan , Xie Jiliang , Li Donghua , Shan Tao , Fan Liuyang
Published: August 2021

Objective

To investigate structural and quantitative alterations of gut microbiota in an experimental model of small bowel obstruction.

Method

A rat model of small bowel obstruction was established by using a polyvinyl chloride ring surgically placed surrounding the terminal ileum. The alterations of gut microbiota were studied after intestinal obstruction. Intraluminal fecal samples proximal to the obstruction were collected at different time points (24, 48 and 72 hours after obstruction) and analyzed by 16s rDNA high-throughput sequencing technology and quantitative PCR (qPCR) for target bacterial groups. Furthermore, intestinal claudin-1 mRNA expression was examined by real-time polymerase chain reaction analysis, and serum sIgA, IFABP and TFF3 levels were determined by enzyme-linked immunosorbent assay.

Results

Small bowel obstruction led to significant bacterial overgrowth and profound alterations in gut microbiota composition and diversity. At the phylum level, the 16S rDNA sequences showed a marked decrease in the relative abundance of Firmicutes and increased abundance of Proteobacteria, Verrucomicrobia and Bacteroidetes. The qPCR analysis showed the absolute quantity of total bacteria increased significantly within 24 hours but did not change distinctly from 24 to 72 hours. Further indicators of intestinal mucosa damage and were observed as claudin-1 gene expression, sIgA and TFF3 levels decreased and IFABP level increased with prolonged obstruction.

Conclusion

Small bowel obstruction can cause significant structural and quantitative alterations of gut microbiota and induce disruption of gut mucosa barrier.
Impact of essential workers in the context of social distancing for epidemic control
Authors: Milligan William R. , Fuller Zachary L. , Agarwal Ipsita , Eisen Michael B. , Przeworski Molly , Sella Guy
Published: August 2021

New emerging infectious diseases are identified every year, a subset of which become global pandemics like COVID-19. In the case of COVID-19, many governments have responded to the ongoing pandemic by imposing social policies that restrict contacts outside of the home, resulting in a large fraction of the workforce either working from home or not working. To ensure essential services, however, a substantial number of workers are not subject to these limitations, and maintain many of their pre-intervention contacts. To explore how contacts among such “essential” workers, and between essential workers and the rest of the population, impact disease risk and the effectiveness of pandemic control, we evaluated several mathematical models of essential worker contacts within a standard epidemiology framework. The models were designed to correspond to key characteristics of cashiers, factory employees, and healthcare workers. We find in all three models that essential workers are at substantially elevated risk of infection compared to the rest of the population, as has been documented, and that increasing the numbers of essential workers necessitates the imposition of more stringent controls on contacts among the rest of the population to manage the pandemic. Importantly, however, different archetypes of essential workers differ in both their individual probability of infection and impact on the broader pandemic dynamics, highlighting the need to understand and target intervention for the specific risks faced by different groups of essential workers. These findings, especially in light of the massive human costs of the current COVID-19 pandemic, indicate that contingency plans for future epidemics should account for the impacts of essential workers on disease spread.
The long-lasting enigma of polycytidine (polyC) tract
Authors: Penza Velia , Russell Stephen J. , Schulze Autumn J.
Published: August 2021

Long polycytidine (polyC) tracts varying in length from 50 to 400 nucleotides were first described in the 5′-noncoding region (NCR) of genomes of picornaviruses belonging to the Cardio- and Aphthovirus genera over 50 years ago, but the molecular basis of their function is still unknown. Truncation or complete deletion of the polyC tracts in picornaviruses compromises virulence and pathogenicity but do not affect replicative fitness in vitro, suggesting a role as “viral security” RNA element. The evidence available suggests that the presence of a long polyC tract is required for replication in immune cells, which impacts viral distribution and targeting, and, consequently, pathogenic progression. Viral attenuation achieved by reduction of the polyC tract length has been successfully used for vaccine strategies. Further elucidation of the role of the polyC tract in viral replication cycle and its connection with replication in immune cells has the potential to expand the arsenal of tools in the fight against cancer in oncolytic virotherapy (OV). Here, we review the published data on the biological significance and mechanisms of action of the polyC tract in viral pathogenesis in Cardio- and Aphthoviruses.
Peace education as a controversial issue: The ‘Peace Case’
Authors: Gürsel-Bilgin Gülistan
Published: August 2021

This qualitative case study examines the Peace Case in its historical context and scrutinizes the complexities. Ms Butera, who became known as the ‘peace teacher’, had to deal with in the aftermath of her remark ‘I honk for peace’ in her classroom. Drawing from the fields of peace education and educational leadership and policy studies, the study aims to shed light to the dominant dynamics in the case, especially those that might be discouraging teachers to integrate the potentially controversial themes related to war and peace into their curricula. To this end, it first discusses peace education as a controversial issue and illustrates several facets of peace education that make it controversial. Following this, an analysis of a post-Garcetti case, which is known as the ‘Peace Case’, is presented. As this analysis sheds light on several implications regarding peace education as a controversial issue and teachers’ freedom of speech in the classroom, these implications are presented for teacher educators in the final section. While scrutinizing the challenging nature of present public schooling through Ms Butera’s struggles, the study uncovers the possibilities of peace education practices even in an oppressive system of schooling through robust teacher education programmes equipping teachers with powerful skills and capabilities required for transformative educators.
Conceptualizing national education and methods of teaching national education in Hong Kong
Authors: Chong King-Man Eric , Hu Jun , Cheng Chi-Keung Eric , Davies Ian , Tang Hei-Hang Hayes , Leung Yan-Wing , Hung Chung-Fun Steven
Published: August 2021

This article aims to generate a better understanding of Hong Kong teachers’ perception of national education as implemented in the Hong Kong Special Administrative Region (hereafter referred to as Hong Kong SAR) and the interrelationship between their perception and the methods they adopt to teach the topic. We outline the Hong Kong context relevant to our research and review the relevant literature to consider typologies and teaching methods about and for national education. Questionnaire data focused on the seven typologies of nationalism and the three teaching methods of national education identified in the literature review. A total of 601 questionnaires were returned from 198 schools. The typologies of cultural nationalism, civic and peripheral nationalism, authoritarian nationalism, unification nationalism and cosmopolitan nationalism, and the teaching methods of group discussion and an affective approach characterize the views of Hong Kong secondary school teachers about national education. We suggest that teachers’ diverse views about nationalism and their varied use of teaching methods to achieve their goals suggest the powerful influence of current initiatives from the Chinese mainland and the need to reflect on established academic literature that proposes the decolonization of the curriculum and interactive and critical teaching methods.