bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Sn-doping on the optoelectronic properties of zinc oxide crystal: DFT approach
Authors: Kumar Manoj , Pandey Purnendu Shekhar , Ravi Banoth , Kumar Bittu , Prasad S. V. S. , Singh Rajesh , Choudhary Santosh Kumar , Singh Gyanendra Kumar
Published: January 2024

This study aims to provide a concise overview of the behavior exhibited by Sn-doped ZnO crystals using a computational technique known as density functional theory (DFT). The influence of Sn doping on the electronic, structural, and optical properties of ZnO have been explored. Specifically, the wavelength dependent refractive index, extinction coefficient, reflectance, and absorption coefficient, along with electronic band gap structure of the Sn doped ZnO has been examined and analyzed. In addition, X-ray diffraction (XRD) patterns have been obtained to investigate the structural characteristics of Sn-doped ZnO crystals with varying concentrations of Sn dopant atoms. The incorporation of tin (Sn) into zinc oxide (ZnO) has been observed to significantly impact the opto-electronic properties of the material. This effect can be attributed to the improved electronic band structure and optical characteristics resulting from the tin doping. Furthermore, the controllable structural and optical characteristics of tin-doped zinc oxide will facilitate the development of various light-sensitive devices. Moreover, the impact of Sn doping on the optoelectronic properties of ZnO is thoroughly investigated and documented.
Mediating role of food insecurity in the relationship between perceived MSM related stigma and depressive symptoms among men who have sex with men in Nepal
Authors: Paudel Kiran , Bhandari Prashamsa , Gautam Kamal , Wickersham Jeffrey A. , Ha Toan , Banik Swagata , Shrestha Roman
Published: January 2024

Background

Previous studies have indicated the association between stigma and depressive symptoms among frequently stigmatized groups, such as men who have sex with men (MSM). While this association has been suggested in the literature, there is a dearth of evidence that examines whether food insecurity statistically mediates the relationship between stigma and depressive symptoms.

Methods

This cross-sectional study conducted between October and December 2022 among a sample of 250 MSM in Kathmandu, Nepal, recruited through respondent-driven sampling. An unadjusted model including the exposure (stigma), mediator (food insecurity), and outcome variables (depressive symptoms) and an adjusted model that controlled for sociodemographic, behavioral, and health-related confounders were used. Bootstrapping was utilized to estimate the coefficients of these effects and the corresponding 95% confidence intervals. Via bootstrap approach, we find out the mediating role of food insecurity in the association between stigma and depressive symptoms.

Results

Depressive symptoms, stigma, and food insecurity were 19.6%, 24.4%, and 29.2%, respectively, among MSM. Food insecurity was associated with higher age (b = 0.094; 95% CI = 0.039, 0.150) and monthly income (b = -1.806; 95% CI = -2.622, -0.985). Depressive symptoms were associated with condom-less sex in past six months (b = -1.638; 95% CI = -3.041, -0.092). Stigma was associated with higher age (b = 0.196; 95% CI = 0.084, 0.323) and PrEP uptake (b = 2.905; 95% CI = 0.659. 5.248). Food insecurity statistically mediated 20.6% of the indirect effect of stigma in depressive symptoms.

Conclusion

Our findings show that food insecurity affects the relationship between stigma and depressive symptoms in this population. Reducing food insecurity and addressing the stigma surrounding sexual orientation should be a priority when addressing mental health concerns among MSM in Nepal and other resource-limited countries with similar socio-cultural settings.
Spatial diversity processing mechanism based on the distributed underwater acoustic communication system
Authors: Zhou Manli , Zhang Hao , Lv Tingting , Gao Yong , Duan Yingying
Published: January 2024

To address the problem of unreliable single-link underwater acoustic communication caused by large signal delays and strong multipath effects in shallow water environments, this paper proposes a distributed underwater acoustic diversity communication system (DUA-DCS). DUA-DCS employs a maneuverable distributed cross-medium buoy network to form multiple distributed, non-coherent, and parallel communication links. In the uplink, a receiving diversity processing mechanism of joint decision feedback equalizer embedded phase-locked loop and maximum signal-to-interference ratio combining (DFE-PLL-MSIRC) is proposed to achieve waveform-level diversity combining of underwater signals. A phase-locked loop module is embedded in each branch of the decision feedback equalizer to eliminate the residual frequency and phase errors after Doppler compensation. Meanwhile, the combining coefficients are determined based on the maximum signal-to-interference ratio criterion, taking into account the residual inter-symbol interference after equalization, resulting in efficient and accurate computation. Additionally, the combined decision values are fed back to the feedback filters in each branch to ensure more accurate feedback output. Simulation and lake experiment results demonstrate that, compared to the single-link communication system, DFE-PLL-MSIRC can achieve a diversity gain of more than 5.2 dB and obtain about 3 dB more diversity gain than the comparison algorithm. And the BER of DFE-PLL-MSIRC can be reduced by at least one order of magnitude, which is lower by at least 0.6 order of magnitude compared to the comparison algorithm. In the downlink, a transmitting diversity processing mechanism of complex orthogonal space-time block coding (COSTBC) is proposed. By utilizing a newly designed generalized complex orthogonal transmission matrix, complete transmission diversity can be achieved at the coding rate of 3/4. Compared to the single-link communication system, the system can achieve a diversity gain of more than 6 dB.
Intra-group differences in skin tone influence evaluative and perceptual face processing
Authors: Amd Micah
Published: January 2024

In an exploration of colorist biases across native Melanesian participants, we employed a multi-method approach across three studies to examine evaluative and perceptual processing of ‘lighter’ and ‘darker’ non-Melanesian facial targets controlled for attractiveness, sex, and ethnicity. In Study 1, 305 participants evaluated facial attractiveness using surveys. In Study 2, 153 participants alternately mapped lighter and darker faces with positive and neutral attributes across brief Implicit Association Tests. In Study 3, 61 participants underwent a manual sorting task followed by a ’breaking’ continuous flash suppression (b-CFS) paradigm to probe ’non-conscious’ perceptual biases. Across evaluative measures, male and female respondents consistently preferred lighter-skinned, highly attractive male faces. During b-CFS, lighter and attractive opposite-sex faces entered awareness (‘broke suppression’) faster than their darker counterparts. We speculate that skin tone may operate as a perceptually salient cue in the presence of facial configurations signaling high reproductive potential.
Developing a strategy to scale up place-based arts initiatives that support mental health and wellbeing: A realist evaluation of ‘Arts for the Blues’
Authors: Karkou Vicky , Omylinska-Thurston Joanna , Thurston Scott , Clark Rebecca , Perris Emma , Kaehne Axel , Pearson Mark
Published: January 2024

Place-based arts initiatives are regarded as rooted in local need and as having capacity to engage local assets. However, many place-based arts initiatives remain poorly funded and short-lived, receiving little attention on how to scale up and sustain their activities. In this study we make a unique contribution to knowledge about scaling up place-based arts initiatives that support mental health and wellbeing through focusing on the example of ‘Arts for the Blues’, an arts-based psychological group intervention designed to reduce depression and improve wellbeing amongst primary care mental health service users in deprived communities. Methodologically, we used realist evaluation to refine the study’s theoretical assumptions about scaling up, drawing on the lived and professional experiences of 225 diverse stakeholders’ and frontline staff through a series of focus groups and evaluation questions at two stakeholders’ events and four training days. Based on our findings, we recommend that to scale up place-based arts initiatives which support mental health and wellbeing: (i) the initiative needs to be adaptable, clear, collaborative, evidence-based, personalised and transformative; (ii) the organisation has to have a relevant need, have an understanding of the arts, has to have resources, inspiration and commitment from staff members, relevant skillsets and help from outside the organisation; (iii) at a policy level it is important to pay attention to attitude shifts towards the arts, meet rules, guidelines and standards expected from services, highlight gaps in provision, seek out early intervention and treatment options, and consider service delivery changes. The presence of champions at a local level and buy-in from managers, local leaders and policy makers are also needed alongside actively seeking to implement arts initiatives in different settings across geographical spread. Our theoretically-based and experientially-refined study provides the first ever scaling up framework developed for place-based arts initiatives that support the mental health and wellbeing, offering opportunities for spread and adoption of such projects in different organisational contexts, locally, nationally and internationally.
Isoniazid preventive therapy completion between July-September 2019: A comparison across HIV differentiated service delivery models in Uganda
Authors: Mugenyi Levicatus , Namuwenge Proscovia Mukonzo , Ouma Simple , Bakashaba Baker , Nanfuka Mastula , Zech Jennifer , Agaba Collins , Mijumbi Ojok Andrew , Kaliba Fedress , Bossa Kato John , Opito Ronald , Miya Yunus , Katureebe Cordelia , Hirsch-Moverman Yael
Published: January 2024

Background

Tuberculosis (TB) remains the leading cause of death among people living with HIV (PLHIV). To prevent TB among PLHIV, the Ugandan national guidelines recommend Isoniazid Preventive Therapy (IPT) across differentiated service delivery (DSD) models, an effective way of delivering ART. DSD models include Community Drug Distribution Point (CDDP), Community Client-led ART Delivery (CCLAD), Facility-Based Individual Management (FBIM), Facility-Based Group (FBG), and Fast Track Drug Refill (FTDR). Little is known about the impact of delivering IPT through DSD.

Methods

We reviewed medical records of PLHIV who initiated IPT between June-September 2019 at TASO Soroti (TS), Katakwi Hospital (KH) and Soroti Regional Referral Hospital (SRRH). We defined IPT completion as completing a course of isoniazid within 6–9 months. We utilized a modified Poisson regression to compare IPT completion across DSD models and determine factors associated with IPT completion in each DSD model.

Results

Data from 2968 PLHIV were reviewed (SRRH: 50.2%, TS: 25.8%, KH: 24.0%); females: 60.7%; first-line ART: 91.7%; and Integrase Strand Transfer Inhibitor (INSTI)-based regimen: 61.9%. At IPT initiation, the median age and duration on ART were 41.5 (interquartile range [IQR]; 32.3–50.2) and 6.0 (IQR: 3.7–8.6) years, respectively. IPT completion overall was 92.8% (95%CI: 91.8–93.7%); highest in CDDP (98.1%, 95%CI: 95.0–99.3%) and lowest in FBG (85.8%, 95%CI: 79.0–90.7%). Compared to FBIM, IPT completion was significantly higher in CDDP (adjusted rate ratio [aRR] = 1.15, 95%CI: 1.09–1.22) and CCLAD (aRR = 1.09, 95% CI 1.02–1.16). In facility-based models, IPT completion differed between sites (p<0.001). IPT completion increased with age for FBIM and CCLAD and was lower among female participants in the CCLAD (aRR = 0.82, 95%CI 0.67–0.97).

Conclusion

IPT completion was high overall but highest in community-based models. Our findings provide evidence that supports integration of IPT within DSD models for ART delivery in Uganda and similar settings.
Factors related to quality of life in community-dwelling adults in Sleman Regency, Special Region of Yogyakarta, Indonesia: Results from a cross-sectional study
Authors: Kusumaningrum Fitrina Mahardani , Dewi Fatwa Sari Tetra , Santosa Ailiana , Pangastuti Heny Suseani , Yeung Polly
Published: January 2024

Background

Quality of life studies in low- and middle-income countries have demonstrated the influence of socioeconomic factors on the quality of life (QoL). However, further studies are required to confirm this association in developing countries with rapidly ageing populations. Using Ferrans et al.’s QoL model, this study aimed to identify the factors associated with the QoL of community-dwelling adults in Indonesia.

Methods

A cross-sectional study among 546 community-dwelling adults aged 50+ years was conducted in Yogyakarta, Indonesia, in 2018. QoL was measured using the Short Form 12 questionnaire, which consists of a summary of physical and mental health. We performed stepwise logistic regression analyses to determine odds ratios (ORs) with 95% confidence intervals (CIs) and examined the association between the QoL (physical and mental health) and demographic characteristics, socioeconomic status, financial management behaviour, multimorbidity status, nutritional status, cognitive impairment status, depression status, and independence. Statistical significance was set at p<0.05.

Results

Among the respondents, 15% reported poor physical health, and 9.2% reported poor mental health. Good physical health was significantly associated with the absence of chronic disease (OR 2.39; 95% CI: 1.07–5.33), independence in activities of daily living (OR 3.90; 95% CI 1.57–9.67) and instrumental activities of daily living (OR 4.34; 95% CI 2.28–8.26). Absence of depression was significantly associated with good mental health (OR 2.80; 95% CI 1.3–5.96).

Conclusion

The QoL of community-dwelling adults in Indonesia is associated with activities of daily living and instrumental activities of daily living, as well as the absence of chronic disease and depression. Efforts should be made to prevent chronic disease and delay functional decline through healthy lifestyles and routine physical and mental health screenings.
A facile method of treating spent catalysts via using solvent for recovering undamaged catalyst support
Authors: Abbas Zaheer , Jung Simon MoonGeun
Published: January 2024

The process of washing and removing crude oil from spent catalysts is a serious issue in both catalyst regeneration and precious metals recovery. In this work, five different solvents with various polar and aromatic properties were chosen to evaluate their impact on the catalyst support structure and crude oil recovery from oil-contaminated spent catalysts. After the deoiling process, the spent catalyst was analyzed by scanning electron microscopy, X-ray diffraction (XRD), Fourier transform-infrared spectroscopy, elemental analyzer, contact angle measurement, gas chromatography-mass spectrometry, inductively coupled plasma-atomic emission spectroscopy, and Brunauer Emmet Teller (BET) method. Our findings demonstrate that p-xylene and kerosene are more effective in removing oil than other solvents. This is due to crude oil’s similar polarity and molecular nature with kerosene and p-xylene. Considering the economical reason, kerosene is a better choice for deoiling spent catalyst compared to p-xylene as it is more affordable than p-xylene. XRD data show that the structure of the catalyst support was unaltered by the solvent treatment process, while BET data reveals that the surface area and pore volume are significantly enhanced after the deoiling process. These results imply that deoiling is a very crucial step for the recycling, regeneration, and reuse of spent catalysts. Our work is significant in developing sustainable approaches for managing spent catalysts, and minimizing waste and environmental pollution.
Effects of physical exercise on executive functions of individuals with schizophrenia spectrum disorders: Protocol for a systematic review and meta-analysis
Authors: Pérez-Romero Nuria , Campos-Jara Christian , Pesce Caterina , Araya Sierralta Sergio , Cerda-Vega Enrique , Ramirez-Campillo Rodrigo , Campos-Jara Rodrigo , Martínez-Salazar Cristian , Arellano-Roco Cristián , Contreras-Osorio Falonn
Published: January 2024

Introduction

Executive functions are commonly impaired in individuals with schizophrenia spectrum disorders. Physical exercise has the potential for improving executive functions and can be easily implemented as a therapeutic method. However, there are only few systematic reviews of exercise effects in schizophrenia including cognitive outcomes, and no meta-analytical syntheses of effects on “cool” and “hot” executive functions. The purpose of this systematic review and meta-analysis will be to determine the effects of physical exercise on “cool” and “hot” executive functions of adults with schizophrenia spectrum disorders.

Methods and analysis

This protocol was guided by PRISMA-P guidelines. Studies will be searched using combinations of keywords and medical terms in the Web of Science, PubMed, Scopus, and EBSCO databases. Inclusion criteria will be determined as per PICOS approach. The risk of bias will be assessed using the Cochrane RoB2 tool. The certainty of evidence (per outcome) will be assessed using the GRADE method. The meta-analyses will be performed using the DerSimonian and Laird random effects model. Effect sizes (Hedges’ g) with 95% confidence intervals will be calculated for each main outcome.

Conclusions

The results of this review may be useful for mental health professionals to design treatment plans for adults with schizophrenia spectrum disorders, offering potential benefits related to the quality of life and cognitive abilities of this population.

PROSPERO registration number

CRD42023392295.
Are non-fungible payments attractive when they reduce risk exposure? Evidence from Colombia
Authors: Cano Alexander , Cortés Darwin , Mantilla César , Prada Laura , Restrepo Medardo
Published: January 2024

We conducted a lab-in-the-field experiment in which 214 Colombian rural workers must choose between cash or voucher payment for completing a real effort task. Although the voucher may be perceived as non-fungible, it halves the probability of suffering a negative shock that will reduce the participant’s payment by two-thirds. Participants made four decisions in which we vary the voucher values such that this payment method offers, in expectation, between 88% to 123% of the cash payment (fixed across decisions). We find that uptake rates go from 32% to 56%, from the least to the most generous voucher. These rates are consistently larger compared to a reference sample of undergrad students from the same region (p–values from the χ2 tests for all four decisions fall below 0.035). Our between-subjects variations reveal that presenting the vouchers in descending order yields a higher uptake than the ascending order (p < 0.001 for the corresponding coefficient in a tobit and ordered logit regressions including municipality characteristics, an effect driven by the two decisions with the lowest voucher values, with p–values of 0.008 and 0.072 in the χ2 tests, respectively). We interpret this result as an endowment effect of the voucher’s risk reduction.
The Bradyrhizobium japonicum exporter ExsFGH is involved in efflux of ferric xenosiderophores from the periplasm
Authors: Ong Alasteir , O’Brian Mark R.
Published: January 2024

The gram-negative bacterium Bradyrhizobium japonicum can take up structurally dissimilar ferric siderophores from the environment (xenosiderophores) to meet its nutritional iron requirements. Siderophore-bound iron transported into the periplasm is reduced to the ferrous form by FsrB, dissociated from the siderophore and the free ion is then transported into the cytoplasm by the ferrous iron transporter FeoAB. Here, we identified the RND family exporter genes exsFG and exsH in a selection for secondary site suppressor mutants that restore growth of an fsrB mutant on the siderophores ferrichrome or ferrioxamine. The low level of radiolabel accumulation from 55Fe-labeled ferrichrome or ferrioxamine observed in the fsrB mutant was restored to wild type levels in the fsrB exsG mutant. Moreover, the exsG mutant accumulated more radiolabel from the 55Fe-labeled siderophores than the wild type, but radiolabel accumulation from inorganic 55Fe was similar in the two strains. Thus, ExsFGH exports siderophore-bound iron, but not inorganic iron. The rescued fsrB exsG mutant required feoB for growth, indicating that ExsFGH acts on those siderophores in the periplasm. The exsG mutant was more sensitive to the siderophore antibiotic albomycin than the wild type, whereas the fsrB mutant was more resistant. This suggests ExsFGH normally exports ferrated albomycin. B. japonicum is naturally resistant to many antibiotics. The exsG strain was very sensitive to tetracycline, but not to six other antibiotics tested. We conclude that ExsFGH is a broad substrate exporter that is needed to maintain siderophore homeostasis in the periplasm.
eDNA metabarcoding reveals the role of habitat specialization and spatial and environmental variability in shaping diversity patterns of fish metacommunities
Authors: Erős Tibor , Funk Andrea , Pont Didier , Hein Thomas , Meulenbroek Paul , Preiszner Bálint , Valentini Alice , Czeglédi István
Published: January 2024

Information is scarce on how environmental and dispersal processes interact with biological features of the organisms, such as their habitat affinity, to influence patterns in biodiversity. We examined the role of habitat specialist vs. generalist species, and the spatial configuration, connectivity, and different environmental characteristics of river-floodplain habitats to get a more mechanistic understanding of alpha and beta diversity of fish metacommunities. We used environmental DNA metabarcoding to characterize species (taxa) richness and composition in two separate floodplains of the river Danube (Austria and Hungary) during two different hydrological conditions. Results showed that differences in the number of generalist and specialist species and their responses to connectivity and environmental gradients influenced patterns in alpha and beta diversity. Of the components of beta diversity, richness difference (nestedness) showed consistently higher values than replacement (turnover), mainly due to the decrease of specialist species along the connectivity gradient (i.e., from the mainstem to the most isolated oxbows). Variance in both alpha and beta diversity could be well predicted by a set of local and regional variables, despite high environmental variability, which characterizes river-floodplain ecosystems. Of these, the joint or shared variance fractions proved to be the most important, which indicates that the effects of local and regional processes cannot be unambiguously separated in these river-floodplain systems. Local scale environmental variables were more important determinants of both alpha and beta diversity in the low water period than in the high water period. These results indicate the differential role of local and regional processes in community organization during different hydrological conditions. Maintenance of both local and regional scale processes are thus important in the preservation of alpha and beta diversity of floodplain fish metacommunities, which should be considered by environmental management.
Factors influencing the uptake of a mono-PrEP implant for the prevention of HIV: Males’ perspectives from three South African provinces
Authors: Mthimkhulu Nqaba , Chidumwa Glory , Kutywayo Alison , Mataboge Paballo , Martin Catherine E. , Kwatsha Khanyiswa , Makalela Nthabiseng , Mazibuko Mbali , Butler Vusile , Mullick Saiqa
Published: January 2024

Introduction

Oral pre-exposure prophylaxis (PrEP) is an effective HIV prevention method; however, males over 15 years face challenges with its effective use. Long-acting prevention products could address barriers to effective PrEP use. This study aimed to estimate the potential uptake of a mono-PrEP implant and the factors influencing uptake among males in South Africa. The study also examined messaging and demand creation tactics that males perceive will improve HIV prevention uptake.

Methods

We conducted a mixed methods study comprising participatory workshops and a self-administered survey among 142 PrEP-eligible males (18–40 years) in three provinces (Gauteng, Eastern Cape, and Kwa-Zulu Natal) in South Africa from July to November 2022. Logistic regression was used to assess the relationship between the potential uptake of a hypothetical, non-biodegradable mono-PrEP implant and socioeconomic and behavioural factors. Workshop data were analysed using content analysis.

Results

The top three HIV prevention products that males would consider using were the monthly pill (74.6%), the mono-PrEP implant (62.7%), and event-driven oral PrEP (59.2%). If one prevention option was available, 31.7% of participants stated that they would use the monthly oral pill, 28.2% would use the six-monthly injection, and 19.7% the mono-PrEP implant. Four key themes were noted as influential to potential mono-PrEP uptake: “Health Over Everything”, “Mono-PrEP Implant Concerns”, “Potential Disclosure of Mono-PrEP Use”, and “Information Distribution Channels”. Participants preferred social and mainstream media as information distribution channels to receive information on HIV prevention services, including the mono-PrEP implant.

Conclusion

In this study among predominantly heterosexual men in South Africa, there was interest in long-acting HIV prevention methods but concerns about the mono-PrEP implant. A comprehensive and participatory introduction will be needed for the implant, to improve acceptability and address potential concerns. Demand-creation strategies utilising social media and health campaigns should be considered to engage and reach males.
Acoustical and behavioral heuristics for fast interactive sound design
Authors: Souaille Ava , Lostanlen Vincent , Lagrange Mathieu , Misdariis Nicolas , Petiot Jean-François
Published: January 2024

During their creative process, designers routinely seek the feedback of end users. Yet, the collection of perceptual judgments is costly and time-consuming, since it involves repeated exposure to the designed object under elementary variations. Thus, considering the practical limits of working with human subjects, randomized protocols in interactive sound design face the risk of inefficiency, in the sense of collecting mostly uninformative judgments. This risk is all the more severe that the initial search space of design variations is vast. In this paper, we propose heuristics for reducing the design space considered during an interactive optimization process. These heuristics operate by using an approximation model, called surrogate model, of the perceptual quantity of interest. As an application, we investigate the design of pleasant and detectable electric vehicle sounds using an interactive genetic algorithm. We compare two types of surrogate models for this task, one based on acoustical descriptors gathered from the literature and the other based on behavioral data. We find that reducing by a factor of up to 64 an original design space of 4096 possible settings with the proposed heuristics reduces the number of iterations of the design process by up to 2 to reach the same performance. The behavioral approach leads to the best improvement of the explored designs overall, while the acoustical approach requires an appropriate choice of acoustical descriptor to be effective. Our approach accelerates the convergence of interactive design. As such, it is particularly suitable to tasks in which exhaustive search is prohibitively slow or expensive.
Proliferation, migration and phenotypic transformation of VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3
Authors: Wang Xiuyu , Gui Na , Ma Xing , Zeng Yue , Mo Tingrun , Zhang Minghao
Published: January 2024

To provide a theoretical basis for the prevention and treatment of atherosclerosis (AS), the current study aimed to investigate the mechanism underlying the effect of homocysteine (Hcy) on regulating the proliferation, migration and phenotypic transformation of vascular smooth muscle cells (VSMC) via sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) through Nedd4-like E3 ubiquitin-protein ligase WWP2 (WWP2). Here, Based on the establishment of ApoE-/- mouse models of high Hcy As and the model of Hcy stimulation of VSMC in vitro to observe the interaction between WWP2 and STAT3 and its effect on the proliferation, migration, and phenotypic transformation of Hcy-induced VSMC, which has not been previously reported. This study revealed that WWP2 could promote the proliferation, migration, and phenotype switch of Hcy-induced VSMC by up-regulating the phosphorylation of SIRT1/STAT3 signaling. Furthermore, Hcy might up-regulate WWP2 expression by inhibiting histone H3K27me3 expression through up-regulated UTX. These data suggest that WWP2 is a novel and important regulator of Hcy-induced VSMC proliferation, migration, and phenotypic transformation.
An improved F98 glioblastoma rat model to evaluate novel treatment strategies incorporating the standard of care
Authors: Zoteva Velislava , De Meulenaere Valerie , De Boeck Marthe , Vanhove Christian , Leybaert Luc , Raedt Robrecht , Pieters Leen , Vral Anne , Boterberg Tom , Deblaere Karel
Published: January 2024

Glioblastoma (GB) is the most common and malignant primary brain tumor in adults with a median survival of 12–15 months. The F98 Fischer rat model is one of the most frequently used animal models for GB studies. However, suboptimal inoculation leads to extra-axial and extracranial tumor formations, affecting its translational value. We aim to improve the F98 rat model by incorporating MRI-guided (hypo)fractionated radiotherapy (3 x 9 Gy) and concomitant temozolomide chemotherapy, mimicking the current standard of care. To minimize undesired tumor growth, we reduced the number of inoculated cells (starting from 20 000 to 500 F98 cells), slowed the withdrawal of the syringe post-inoculation, and irradiated the inoculation track separately. Our results reveal that reducing the number of F98 GB cells correlates with a diminished risk of extra-axial and extracranial tumor growth. However, this introduces higher variability in days until GB confirmation and uniformity in GB growth. To strike a balance, the model inoculated with 5000 F98 cells displayed the best results and was chosen as the most favorable. In conclusion, our improved model offers enhanced translational potential, paving the way for more accurate and reliable assessments of novel adjuvant therapeutic approaches for GB.
Serum level of full-length connective tissue growth factor reflects liver fibrosis stage in patients with Fontan-associated liver disease
Authors: Kogiso Tomomi , Takayanagi Kayo , Ishizuka Tsutomu , Otsuka Motoyuki , Inai Kei , Ogasawara Yuri , Horiuchi Kentaro , Taniai Makiko , Tokushige Katsutoshi
Published: January 2024

Background

Chronic liver disease leads to liver fibrosis, and an accurate diagnosis of the fibrosis stage is crucial for medical management. Connective tissue growth factor (CTGF) is produced by endothelial cells and platelets and plays a central role in inducing fibrosis in various organs. In the present study, we tested the validity of measuring the serum levels of two types of CTGF to estimate the biopsy-confirmed liver fibrosis stage.

Methods

We used two detection antibodies targeting the N- and C-terminal of CTGF to measure the serum levels of two forms of CTGF consisting of its full length and its N-terminal fragment. We analyzed the level of CTGF (via enzyme-linked immunosorbent assay) and the liver fibrosis stage in 38 patients with Fontan-associated liver disease (FALD) (26 cases of which were diagnosed pathologically). Correlations were determined by multivariate analysis and the area under the receiver operating characteristic curve. The 65 patients with nonalcoholic fatty liver disease (NAFLD) were included as a disease control group for examination.

Results

Full-length CTGF was significantly inversely correlated with liver fibrosis in patients with FALD. Although the platelet count was also associated with the liver fibrosis stage, full-length CTGF was more closely correlated with the fibrosis stage. Furthermore, the level of full-length CTGF was inversely associated with high central venous pressure. Conversely, the serum level of CTGF was not correlated with the fibrosis stage in NAFLD.

Conclusion

The serum level of full-length CTGF may be useful for estimating the liver fibrosis stage in patients with FALD.
Predicting invasive mechanical ventilation in COVID 19 patients: A validation study
Authors: Statlender Liran , Shvartser Leonid , Teppler Shmuel , Bendavid Itai , Kushinir Shiri , Azullay Roy , Singer Pierre
Published: January 2024

Introduction

The decision to intubate and ventilate a patient is mainly clinical. Both delaying intubation (when needed) and unnecessarily invasively ventilating (when it can be avoided) are harmful. We recently developed an algorithm predicting respiratory failure and invasive mechanical ventilation in COVID-19 patients. This is an internal validation study of this model, which also suggests a categorized “time-weighted” model.

Methods

We used a dataset of COVID-19 patients who were admitted to Rabin Medical Center after the algorithm was developed. We evaluated model performance in predicting ventilation, regarding the actual endpoint of each patient. We further categorized each patient into one of four categories, based on the strength of the prediction of ventilation over time. We evaluated this categorized model performance regarding the actual endpoint of each patient.

Results

881 patients were included in the study; 96 of them were ventilated. AUC of the original algorithm is 0.87–0.94. The AUC of the categorized model is 0.95.

Conclusions

A minor degradation in the algorithm accuracy was noted in the internal validation, however, its accuracy remained high. The categorized model allows accurate prediction over time, with very high negative predictive value.
Design and use of a wireless temperature measurement network system integrating artificial intelligence and blockchain in electrical power engineering
Authors: Dong Dianshuai , Feng Hongliang
Published: January 2024

This work aims to investigate the potential fire hazard stemming from the overheating of power equipment. The advent of the artificial intelligence era has facilitated the fusion of blockchain and Internet of Things (IoT) technologies. This work delves into the technical standards for IoT equipment monitoring and smart grid communication, and the IoT environment of power grid equipment. This work introduces a temperature monitoring network tailored for IoT wireless power equipment suitable for the power environment, and conducts system debugging in the power laboratory. The findings affirm that the temperature out-of-limit alarm testing has met the required criteria, confirming the system’s ability to issue timely warnings when temperatures breach a predefined threshold, effectively avoiding high-temperature misfires. This work fully harnesses the secure and user-friendly operation of smart blockchain and the wireless sensing technology of the IoT to realize online monitoring and remote temperature measurement of the power system. It can effectively prevent equipment from overheating and damage, and promote the development of equipment condition monitoring technology in electric power engineering.
Identification of heterosis and combining ability in the hybrids of male sterile and restorer sorghum [Sorghum bicolor (L.) Moench] lines
Authors: Zhang Yizhong , Chen Jing , Gao Zhenfeng , Wang Huiyan , Liang Du , Guo Qi , Zhang Xiaojuan , Fan Xinqi , Wu Yuxiang , Liu Qingshan
Published: January 2024

In sorghum [Sorghum bicolor (L.) Moench], combining ability and heterosis analysis are commonly used to evaluate superior parental lines and to screen for strongly heterotic hybrids, which helps in sorghum variety selection and breeding. In this context, combining ability and heterosis analysis were assessed using 14 restorer lines and seven cytoplasmic male sterile (CMS) lines in 2019 and 2020. The analysis of variance of all cross combinations had highly significant differences for all characters studied, which indicated a wide variation across the parents, lines, testers, and crosses. Combining ability analysis showed that the general combining ability (GCA) and specific combining ability (SCA) of the different parents were differed significantly among different traits. Most combinations with high SCA also showed high GCA in their parent lines. The heritability in the narrow sense of grain weight per panicle and grain yield was relatively low, indicating that the ability of these traits to be directly inherited by offspring was weak, that they were greatly affected by the environment. The better-parent heterosis for plant height, grain weight per panicle, panicle length, and 1000-grain weight was consistent with the order of mid-parent heterosis from strong to weak. The GCA effects of two lines 10480A, 3765A and three testers 0-30R, R111, and JY15R were significant for the majority of the agronomic traits including grain yield and might be used for improving the yield of grains in sorghum as parents of excellent specific combining ability. Seven strongly heterotic F1 hybrids were screened; of these, hybrids 3765A × R111, 1102A × L2R, and 3765A × JY15R showed significant increases in seed iristectorigenin A content and will feature into the creation of new sorghum varieties rich in iristectorigenin A.
A comprehensive scan of psychological disciplines through self-identification on Google Scholar: Relative endorsement, topical coverage, and publication patterns
Authors: Denissen Jaap J. A. , Rauthmann John F.
Published: January 2024

Psychological researchers often identify with psychological disciplines, such as social or clinical psychology. The current study analyzed Google Scholar profiles from 6,532 international scientists who attracted more than 100 citations in 2019 and self-identified with at least one of 10 common psychological disciplines (psychoanalysis; clinical psychology; (cognitive) neuroscience; developmental psychology; educational psychology; experimental psychology; biological psychology/psychophysiology; mathematical psychology/psychometrics; social psychology; personality psychology). Results indicated that almost half of all psychologists self-identified with either social psychology or cognitive neuroscience. There were 487 topics that were endorsed at least five times, ranging from highly discipline-specific topics to more integrative ones, such as emotion and personality. We also factor-analyzed frequencies of topical endorsement across disciplines and found two factors, which we interpreted as reflecting correlational and experimental research traditions (with social psychology being the largest discipline within the former tradition and cognitive neuroscience being the largest discipline within the latter tradition). Differences in productivity and impact were also found, with researchers identifying with psychometrics being the most productive and researchers identifying with personality psychology, cognitive neuroscience, and multidisciplinary psychology as the most impactful in terms of citation increases per additional output. Recommendations for promoting cross-fertilization across psychological disciplines are formulated.
Towards Digital Twin-Oriented Complex Networked Systems: Introducing heterogeneous node features and interaction rules
Authors: Wen Jiaqi , Gabrys Bogdan , Musial Katarzyna
Published: January 2024

This study proposes an extendable modelling framework for Digital Twin-Oriented Complex Networked Systems (DT-CNSs) with a goal of generating networks that faithfully represent real-world social networked systems. Modelling process focuses on (i) features of nodes and (ii) interaction rules for creating connections that are built based on individual node’s preferences. We conduct experiments on simulation-based DT-CNSs that incorporate various features and rules about network growth and different transmissibilities related to an epidemic spread on these networks. We present a case study on disaster resilience of social networks given an epidemic outbreak by investigating the infection occurrence within specific time and social distance. The experimental results show how different levels of the structural and dynamics complexities, concerned with feature diversity and flexibility of interaction rules respectively, influence network growth and epidemic spread. The analysis revealed that, to achieve maximum disaster resilience, mitigation policies should be targeted at nodes with preferred features as they have higher infection risks and should be the focus of the epidemic control.
Determinants of exports performance: Evidence from Indonesian low-, medium-, and high-technology manufacturing industries
Authors: Handoyo Rossanto Dwi , Ibrahim Kabiru Hannafi , Rahmawati Yessi , Faadhillah Faizal , Ogawa Keiichi , Kusumawardani Deni , See Kok Fong , Kumaran Vikniswari Vija , Gulati Rachita
Published: January 2024

This study explores the determinants of the export performance of Indonesia’s low-, medium-, and high-technology manufacturing industries by focusing on the role of raw-material imports and technical efficiency. Micro firm-level data from 2010–2015 were utilized for the analysis in this study. The stochastic frontier analysis was employed to measure technical inefficiency and to determine its effect on export performance. Our findings indicate that in all categories of industry technical efficiency, raw materials imports, foreign direct investment (FDI), location, firm size, labour productivity, and concentration of industries were significant determinants of export performance. While high efficiency increases exports in low- and medium-technology firms, exports decrease in firms with high efficiency accompanied by high imports, FDI, size, and labour productivity. Furthermore, in high-technology industries, efficiency reduces exports and again increases them when mediated by a concentration of industries and location. The empirical strategy also supports the positive effect of imports on export performance in both industries, which also aligns with decreased exports in firms with high imports accompanied by high FDI, efficiency, labour productivity, the concentration of industries, and size. To this end, the study has implications for low-, medium-, and high-technology manufacturing that are mainly concerned with increasing exports.
Alpha-1 antitrypsin deficiency and pregnancy complications and birth outcomes: A population-based cohort study in Denmark
Authors: Orimoloye Helen T. , He Di , Li Tong , Janzen Carla , Barjaktarevic Igor , Wang Xuexia , Hansen Johnni , Heck Julia E.
Published: January 2024

Background

Alpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes.

Objective

We investigated the risk of pregnancy complications and adverse birth outcomes in mothers and children with AATD.

Methods

Using a large cohort data of Danish mothers and children with AATD from 1973 to 2013 (n = 2,027,229), with 559 cases (305 mothers and 254 children). We conducted Poisson regression to examine associations between alpha-1 antitrypsin deficiency, adverse birth outcomes, and pregnancy complications in mothers and children.

Results

AATD was related to term low birth weight [<2500g; Risk Ratio(RR) = 2.04, 95% confidence interval (CI): 1.50–2.79], lowest quartile of abdominal circumference at birth in children of non-smoking mothers (RR = 1.55, 95% CI: 1.14–2.11), delivery via Cesarean-section (RR = 1.59, 95% CI: 1.05–2.40), preterm birth (RR = 1.54, 95% CI: 1.19–2.00) and preeclampsia (RR = 2.64, 95% CI: 1.76–3.94).

Conclusions

This emphasizes the need for mothers with AATD to be monitored closely during pregnancy to reduce the risk of adverse birth outcomes. Routine screening for alpha-1 antitrypsin in pregnancy may be considered among mothers with a pulmonary and liver disease history.
Analysis of clinical factors associated with Kampo formula-induced pseudoaldosteronism based on self-reported information from the Japanese Adverse Drug Event Report database
Authors: Uneda Kazushi , Kawai Yuki , Kaneko Akira , Kayo Takumi , Akiba Shuichiro , Ishigami Tomoaki , Yoshida-Komiya Hiromi , Suzuki Masao , Mitsuma Tadamichi
Published: January 2024

Drug-induced pseudoaldosteronism is a typical adverse effect of Kampo formulas. Previous research described the potential risks of Kampo formula-linked pseudoaldosteronism. However, few studies assessed the risk factors using a real-world database and a data-mining approach. Using the Japanese Adverse Drug Event Report database, we extracted pseudoaldosteronism reports for 148 Kampo formulas covered by Japanese national health insurance. Adverse events were decided according to the preferred terminology of the Medical Dictionary for Regulatory Activities/Japanese version 25.1. We calculated reporting odds ratio (RORs) and identified Kampo formulas as suspected causes of pseudoaldosteronism. Moreover, we evaluated clinical factors associated with Kampo formula-induced pseudoaldosteronism via logistic regression. From April 2004 to November 2022, 6334 adverse events related to the Kampo formulas were reported. We selected 2471 reports containing complete clinical data, including 210 reports on pseudoaldosteronism. In the pseudoaldosteronism group, 69.0% of patients were female, and 85.2% were ≥70 years old. The formulas most commonly associated with pseudoaldosteronism were Shakuyakukanzoto, Yokukansan, and Ryokeijutsukanto (ROR [95% confidence interval {CI}] = 18.3 [13.0–25.9], 8.1 [5.4–12.0], and 5.5 [1.4–21.9], respectively). Logistic analysis identified female sex (odds ratio [OR] [95% CI] = 1.7 [1.2–2.6]; P = 0.006), older age (≥70, 5.0 [3.2–7.8]; P < 0.001), low body weight (<50 kg, 2.2 [1.5–3.2]; P < 0.001), diuretics usage (2.1 [1.3–4.8]; P = 0.004), hypertension (1.6 [1.1–2.4]; P = 0.014), and dementia (7.0 [4.2–11.6]; P < 0.001) as pseudoaldosteronism-related factors. Additionally, the daily Glycyrrhiza dose (OR = 2.1 [1.9–2.3]; P < 0.001) and duration of administration (>14 days, OR = 2.8 [1.7–4.5]; P < 0.001) were associated with adverse events. We did not observe an interaction between aging and hypertension. Careful follow-up is warranted during long-term Glycyrrhiza-containing Kampo formula use in patients with multiple clinical factors for pseudoaldosteronism.
Estimating speaker direction on a humanoid robot with binaural acoustic signals
Authors: Barot Pranav , Mombaur Katja , MacDonald Ewen N.
Published: January 2024

To achieve human-like behaviour during speech interactions, it is necessary for a humanoid robot to estimate the location of a human talker. Here, we present a method to optimize the parameters used for the direction of arrival (DOA) estimation, while also considering real-time applications for human-robot interaction scenarios. This method is applied to binaural sound source localization framework on a humanoid robotic head. Real data is collected and annotated for this work. Optimizations are performed via a brute force method and a Bayesian model based method, results are validated and discussed, and effects on latency for real-time use are also explored.