bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Synthesis and Anticonvulsant Activity of Cinnamoyl Derivatives of 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1-(2H)-one Oxime
Authors: Mokrov Grigory V. , Biryukova Valentina E. , Vorobieva Tatiana Y. , Pantileev Andry S. , Grigorkevich Oksana S. , Zhmurenko Ludmila A. , Rebeko Alexey G. , Bayburtskiy Felix S. , Litvinova Svetlana A. , Voronina Tatiana A. , Gudasheva Tatiana A. , Seredenin Sergei B.
Published: September 2023

Background:

Epilepsy continues to be a significant global health problem and the search
for new drugs for its treatment remains an urgent task. 5-HT2 and GABAA-receptors are among
promising biotargets for the search for new anticonvulsants.

Methods:

New potential 5-HT2 and GABAA ligands in the series of substituted cinnamoyl derivatives
of 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1-(2H)-one oxime were designed using pharmacophore
model and molecular docking analysis. The synthesis of new compounds was carried out from
3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1(2H)-one oxime and substituted cinnamoyl chlorides. The
anticonvulsant activity of new substances has been established using the maximal electroshock seizure
test.

Results:

Several synthesized substituted cinnamoyl derivatives of 3,4,6,7,8,9-hexahydrodibenzo
[b,d]furan-1-(2H)-one oxime significantly reduced the severity of convulsive manifestations and
completely prevented the death of animals after MES. The structure-activity relationship was investigated.
The most effective compound was found to be GIZH-348 (1g) (3,4,6,7,8,9-hexahydrodibenzo[
b,d]furan-1(2Н)-one О-(4-chlorophenyl)acryloyl)oxime) at the doses of 10-20 mg/kg.

Conclusion:

Molecular and pharmacophore modelling methods allowed us to create a new group of
substituted cinnamoyl derivatives of 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1-(2H)-one oxime with
anticonvulsant activity.
The Potential Role of Soybean Bioactive Peptides in the Prevention and
Cure of Carcinoma and Cardiovascular Disorder
Authors: Singh Kuldeep , Gupta Jeetendra Kumar , Kumar Shivendra , Singh Talever
Published: September 2023

Bioactive peptides derived from soybeans have recently been identified as having potential
health benefits for preventing and curing cancer and cardiovascular disorders. This narrative
review focuses on the potential role of these peptides in such conditions and the possible mechanisms
by which they may act. Soybean-derived bioactive peptides have been found to possess antitumor,
antioxidant, anti-inflammatory, and cholesterol-lowering effects. Animal and in vitro studies
have demonstrated that these peptides can modulate multiple signaling pathways, including those
involved in the regulation of apoptosis, angiogenesis, and cell proliferation. Furthermore, they may
protect against oxidative stress and lipid accumulation, which are associated with cancer and cardiovascular
diseases. Also, soybean peptides have been shown to stop enzymes from breaking down
cancer-causing chemicals and reduce the production of pro-inflammatory cytokines, which are
linked to a higher risk of heart disease. The potential of soybean-derived peptides as a therapeutic
tool in cancer and cardiovascular diseases is promising. However, further studies are needed to elucidate
their mechanisms of action and assess their safety and efficacy in clinical settings.
Fatty Acid Metabolism Signature Contributes to the Molecular Diagnosis
of a Malignant Gastric Cancer Subtype with Poor Prognosis and Lower
Mutation Burden
Authors: Chen Zhengwei , Cheng Guoxiong
Published: September 2023

Background:

Gastric cancer (GC) is a common gastrointestinal tumor with high morbidity
and mortality. Fatty acid metabolism (FAM) contributes to GC development. Patents have
been issued for the use of compositions comprising fatty acid analogues for the treatment of many
clinical conditions. However, its clinical significance and its relationship with tumor-related mutations
have not been thoroughly discovered. This study was conducted to analyze and explore
FAM-related genes’ molecular characteristics, prognostic significance, and association with tumor-
related mutations.

Methods:

The gastric adenocarcinoma’s transcriptome, clinical data, and tumor mutation load
(TMB) data were downloaded from TCGA and GEO databases. The differentially expressed FAM
genes (FAM DEGs) between cancer and control samples were screened, and their correlation with
TMB and survival was analyzed. A PPI network of FAM DEGs was constructed, and a downscaling
clustering analysis was performed based on the expression of the FAM DEGs. Further immuno-
infiltration and GO/KEGG enrichment analyses of the identified FAM clusters were performed
to explore their heterogeneity in biological functions. The effects of FAM score and gastric cancer
(STAD) on TMB, MSI, survival prognosis, and drug sensitivity were jointly analyzed, and finally,
a single-gene analysis of the obtained core targets was performed.

Results:

Through differential analysis, 68 FAM DEGs were obtained, and they were highly associated
with STAD tumor mutation load. In addition, a high FAM DEGs CNV rate was observed.
The PPI network showed a complex mutual correlation between the FAM DEGs. Consensus clustering
classified the patients into three clusters based on the FAM DEGs, and the clusters presented
different survival rates. The GSVA and immune infiltration analysis revealed that metabolism,
apoptosis, and immune infiltration-related pathways were variated. In addition, FAM genes,
STAD prognostic risk genes, and PCA scores were closely associated with the survival status of
STAD patients. FAM score was closely correlated with STAD TMB, MSI, and immunotherapy,
and the TMB values in the low FAM score group were significantly higher than those in the high
FAM score group. Finally, combining the above results, it was found that the core gene PTGS1
performed best in predicting STAD survival prognosis and TMB/MSI/immunotherapy.

Conclusion:

Fatty acid metabolism genes affect the development of gastric adenocarcinoma and
can predict the survival prognosis, tumor mutational load characteristics, and drug therapy sensitivity
of STAD patients, which can help explore more effective immunotherapy targets for GC.
Drug-herb Synergistic Interactions between Clopidogrel and Natural
Medicine
Authors: Ma Shitang , Zhang Qin , Hou Jiafu , Liu Shijuan , Feng Chengtao
Published: September 2023

Introduction:

Natural medicine (NM) has been used since ancient times for therapeutic
purposes worldwide. Presently, the combination of clopidogrel and NM with a reasonable synergistic
effect has gained increasing acceptance in clinical therapeutics.

Methods:

Here, we have performed a comprehensive retrieval of literature published in both English
and Chinese databases until August 1, 2022, studying the synergistic interactions of
clopidogrel and NM through pharmacokinetic/pharmacodynamic (PK-PD) analyses. We retrieved
7, 3, and 5 studies on PK analysis and 3, 3, and 8 studies on PD analysis for the interaction of
clopidogrel with single herbal medicines, bioactive compounds, and herbal prescriptions, respectively.
Most studies on NM have been found to mainly focus on preclinical observations, and there
have been fewer clinical PK analyses.

Results:

A potential drug-herb interaction has been observed to occur when clopidogrel and NM
were metabolized by an enzyme network comprising P-gp, CES1, and CYP450. In contrast, most
PD studies have focused on clinical observations, and few preclinical findings have been reported.
Some cases have suggested that the combination of the two types of drugs would alter the antiplatelet
efficacy and adverse effects. Studies on PK, however, have shown significant or slightly
varying results for the drug prototype and its metabolites.

Conclusion:

In the combination therapies, the interaction between clopidogrel and NM was found
to alter antiplatelet aggregation pathways and P2Y12 receptor function.
Investigation on Anti-diabetic Efficacy of a Cucurbitaceae Food Plant from
the North-East Region of India: Exploring the Molecular Mechanism
through Modulation of Oxidative Stress and Glycosylated Hemoglobin
(HbA1c)
Authors: Jana Sandipan , Gayen Srijon , Das Gupta Barun , Singha Seha , Mondal Jayashree , Kar Amit , Nepal Abhimanyu , Ghosh Suparna , Rajabalaya Rajan , David Sheba R. , Balaraman Ashok Kumar , Bala Asis , Mukherjee Pulok Kumar , Haldar Pallab Kanti
Published: September 2023

Background:

The medicinal plants of the Cucurbitaceae family, such as Solena heterophylla Lour. fruits, have significant ethnobotanical value and are readily accessible in North East India.

Aim:

We conducted a study on Solena heterophylla Lour. fruits to evaluate their anti-diabetic activity in vivo, standardize their HPTLC, and profile their metabolites using LC-QTOF-MS. We aimed to explore the molecular mechanism behind their effects on oxidative stress and glycosylated hemoglobin (HbA1c).

Methods:

Firstly, the ethyl acetate fraction of Solena heterophylla Lour. fruits was standardized using Cu-curbitacin B as a standard marker by conducting HPTLC evaluation. Next, we delved into analyzing me-tabolite profiling. In addition, the standardized fraction was utilized in an experimental study to investigate the molecular mechanism of action in an in vivo high-fat diet and a low dose of streptozotocin-induced diabetic model.

Result:

We have reportedly identified 52 metabolites in the ethyl acetate fraction of Solena heterophylla (EASH). In the in vitro tests, it has been observed that this extract from plants possesses notable inhibitory properties against α-amylase and α-glucosidase. Solena heterophylla fruits with high levels of Cucurbitacin B (2.29% w/w) helped lower FBG levels in animals with EASH treatment. EASH treatment reduced HbA1c levels and normalized liver lipid peroxidation and antioxidant enzyme levels. SGOT, SGPT, and SALP serum enzyme levels also returned to normal.

Conclusion:

Based on the current evaluation, it was found that EASH exhibited encouraging hypoglycemic effects in diabetic rats induced by a low dose of STZ and high-fat diet, which warrants further investigation.
A Deeply Quiescent Subset of CML LSC depend on FAO yet Avoid Deleterious
ROS by Suppressing Mitochondrial Complex I
Authors: Chimge Nyam-Osor , Chen Min-Hsuan , Nguyen Cu , Zhao Yuqi , Wu Xiwei , Gonzalez Paulina Garcia , Ogana Heather , Hurwitz Samantha , Teo Jia-Ling , Chen Xiaolong , Du Juan , Jin Victor , Kim Yong-Mi , Ono Masaya , Argüello Rafael J. , Kahn Michael
Published: September 2023

Background and Objective:

Disease relapse and therapy resistance remain serious impediments to treating cancer. Leukemia stem cells (LSC) are therapy resistant and the cause of relapse. A state of deep quiescence appears to enable cancer stem cells (CSC) to acquire new somatic mutations essential for disease progression and therapy resistance. Both normal hematopoietic stem cells (HSC) and LSC share many common features, thereby complicating the safe elimination of LSC. A recent study demonstrated that long lived normal oocytes exist without mitochondrial complex I (MC-1), expressing it in a developmentally regulated fashion, thereby mitigating their vulnerability to ROS. Quiescent CSC rely on mitochondrial FAO, without complex I expression, thereby avoiding the generation of damaging ROS, similar to long lived normal human stem cells. A deeper understanding of the biology of therapy resistance is important for the development of optimal strategies to attain complete leukemia cures.

Methods:

Here, using scRNA-sequencing and ATAC-seq on primary chronic myelogenous leukemia (CML) patient samples, combined with bioinformatics analyses, we further examine the heterogeneity of a previously characterized in vitro imatinib-selected CD34-CD38- CML LSC population. We utilized a series of functional analyses, including single-cell metabolomic and Seahorse analyses, to validate the existence of the deepest quiescent leukemia initiators (LI) subset.

Results:

Current study revealed heterogeneity of therapy resistant LSC in CML patients and their existence of two functionally distinct states. The most deeply quiescent LI suppress the expression of MC-1, yet are highly dependent on fatty acid oxidation (FAO) for their metabolic requirements and ATAC-seq demonstrated increased chromatin accessibility in this population, all consistent with an extremely primitive, quiescent stemness transcriptional signature. Importantly, the specific CREB binding protein (CBP)/β-catenin antagonist ICG-001 initiates the differentiation of LSC, including LI, decreases chromatin accessibility with differentiation and increasing expression of MC-1, CD34, CD38 and BCR-ABL1, thereby re-sensitizing them to imatinib.

Conclusion:

We investigated the biological aspects related to LSC heterogeneity in CML patients and demonstrated the ability of specific small molecule CBP/β-catenin antagonists to safely eliminate deeply quiescent therapy resistant CSC. These observations may represent an attractive generalizable therapeutic strategy that could help develop better protocols to eradicate the quiescent LSC population.
Nanobiosensors: Concepts and Emerging Clinical Applications
Authors: Desai Sagar , Naveen Raghavendra , Goudanavar Prakash S , Gowthami Buduru
Published: September 2023

Biosensors have been one of the most fascinating topics for scientists for a long time. This is because biological moieties are multifaceted and are unswervingly related to the presence of a healthy atmosphere. The biosensor approach has also endured profound changes in recent years. Biosensors have been emphasized for various applications, including food quality estimation, surveillance systems, and health and metabolic abnormality diagnostics. The advances in nanotechnology have led to a considerable potential to enhance biosensors' sensitivity, robustness, and anti-interference capabilities. Several new nanomaterials (such as nanoparticles, nanotubes, nanorods, and nanowires) have been fabricated due to the evolution of nanotechnology, and their unique features are gradually being identified, allowing for much faster detection and reproducibility. Biosensor performance has also been enhanced substantially as a result of their use. Because of their capacity to detect a wide range of compounds at deficient concentrations, nanobiosensors have sparked much interest. This article discusses biosensors based on various nanomaterials, their evolution, accompanying features, and their applications in multiple fields.
A Review on Pharmacological Potential of Medicago sativa Linn
Authors: Rani Rashmi , Nain Sumitra , Paliwal Sarvesh
Published: September 2023

Background:

Medicago sativa Linn. in Hindi, is called lasunghas, and in English, it is called alfalfa. It is a well-known crop of the Fabaceae family. We can eat its sprouts as a salad vegetable. This plant has a wide range of uses as a feed crop and is tolerant to climate change.

Objective:

In this review, the authors discussed the active chemical constituents and pharmacological uses of Medicago sativa Linn. in various diseases.

Methods:

This review article gathered all the information after going through the research papers from different databases like Taylor & Francis, ResearchGate, Elsevier, PubMed, Wiley Online Library, and PMC.

Results:

Alfalfa has been shown to be an important origin of phytochemicals like amino acids, coumarins, alkaloids, carotenes, flavonoids, organic acids, digestive enzymes, phytosterols, saponins, phytoestrogens, phenolic compounds, polyamines, and a few other volatile organic compounds like ketones, terpenes, alcohols and furanoids. This plant is useful in CNS, anxiety, oxidative stress, hepatotoxicity, inflammation, cancer, atherosclerosis, diabetes, burn wounds, vitiligo, reproductive system, myocardial infraction, bacteria, xanthine oxidase and metabolic syndrome.

Conclusion:

This review may be helpful in knowing of Medicago sativa Linn. with greater therapeutic potential for treatment of various diseases.
Antihyperglycemic and Hypolipidemic Effect of Hydroalcoholic Extract of Dolichos lablab Linn in STZ induced Type 1 Diabetes Mellitus in Mice
Authors: Kishan Hari , Choudhary Manjusha , Sharma Sachin , Bamrah Prabhjeet Kaur , Choudhary Nitesh
Published: September 2023

Background:

Traditional herbs have been used in the human healthcare system as medicines, foods, or spices from ancient times. Dolichos lablab is an Indian medicinal herb with a good source of nutrition, and has insulin-like proteins, thus can be employed in the cure of diabetes.

Objective:

This study aims to evaluate the lipids and blood glucose lowering effect of Dolichos lablab hydroalcoholic extract by using STZ-induced type 1 diabetes mellitus in-vivo model.

Methods:

Animals were divided into five groups including vehicle control, diabetic control, extract treated (200 & 400 mg/kg), and standard group. All the treatment was continued for 14 days after the confirmation of diabetes. Food consumption, water intake, serum glucose, insulin, kidney function test, liver, and serum lipid profile were assessed to evaluate the antidiabetic potential of the plant.

Results:

Phytochemical analysis showed the presence of carbohydrates, alkaloids, flavonoids, protein, amino acids, and terpenoids. Extract treatment significantly diminished HbA1c, and blood glucose levels. In addition, an ameliorative effect on serum cholesterol, triglycerides, and lipoprotein was observed at 400 mg/kg/day dose. Moreover, blood urea nitrogen and hepatic SGPT were also reduced significantly with extract treatment.

Conclusion:

Therefore, the present study depicted that Dolichos lablab is a useful herb in diabetes management and possesses hypolipidemic potential.
Investigation of Home Health Care Patients' Attitudes and Behaviors Against COVID-19 Vaccines
Authors: EVCAN Ahmet , TUNCER Özge
Published: September 2023

Introduction: We aimed to find the attitudes and behaviours of home health patients towards COVID-19 vaccines, the rates of vaccination, and the reasons for not getting the vaccine.
Method: This descriptive and cross-sectional study was conducted with patients who were accepted to join this research and reachable (N:1012) registered in the Home Health Services unit of a training and research hospital in Izmir between December 2021 and March 2022. The study was conducted by contacting the patient or their relatives by phone, visiting them at home, or applying a questionnaire during their application to the polyclinic unit. Questionnaire; It consists of 15 questions that help us learn the patient's sociodemographic characteristics, current health status, and attitudes and behaviors about vaccines. The prepared database has entered the IBMSPSS 24.0 program.
Results: The mean age of the participants in the study was 77.4±16.2 years. 68.6% of the participants were women. 63% of them are fully dependent on the bed. In our study, the rate of patients receiving the COVID-19 vaccine was 83.2%. 91.1% of the vaccinated individuals had the Sinovac vaccine, which was first provided to the patients. 66.1% of vaccinated individuals have accessed vaccination services at home. Those who have higher educational levels have higher vaccination rates. Those who received information from their family doctor were significantly more likely to be vaccinated. Participants most frequently stated that they were not vaccinated because they thought they did not have enough information about COVID-19 vaccines and were worried about possible side effects.
Conclusion: According to this study, patients registered with Home Care Unit have a high rate of getting the COVID-19 vaccine.
Role of Caregivers in Remote Management of Patients With Type 2 Diabetes Mellitus: Systematic Review of Literature
Authors: Seng Jun Jie Benjamin , Gwee Meng Ferng Ryan , Yong Mei Hui Amanda , Kwan Yu Heng , Thumboo Julian , Low Lian Leng
Published: September 2023

Background

With the growing use of remote monitoring technologies in the management of patients with type 2 diabetes mellitus (T2DM), caregivers are becoming important resources that can be tapped into to improve patient care.

Objective

This review aims to summarize the role of caregivers in the remote monitoring of patients with T2DM.

Methods

We performed a systematic review in MEDLINE, Embase, Scopus, PsycINFO, and Web of Science up to 2022. Studies that evaluated the role of caregivers in remote management of adult patients with T2DM were included. Outcomes such as diabetes control, adherence to medication, quality of life, frequency of home glucose monitoring, and health care use were evaluated.

Results

Of the 1198 identified citations, 11 articles were included. The majority of studies were conducted in North America (7/11, 64%) and South America (2/11, 18%). The main types of caregivers studied were family or friends (10/11, 91%), while the most common remote monitoring modalities evaluated were interactive voice response (5/11, 45%) and phone consultations (4/11, 36%). With regard to diabetes control, 3 of 6 studies showed improvement in diabetes-related laboratory parameters. A total of 2 studies showed improvements in patients’ medication adherence rates and frequency of home glucose monitoring. Studies that evaluated patients’ quality of life showed mixed evidence. In 1 study, increased hospitalization rates were noted in the intervention group.

Conclusions

Caregivers may play a role in improving clinical outcomes among patients with T2DM under remote monitoring. Studies on mobile health technologies are lacking to understand their impact on Asian populations and long-term patient outcomes.
Exploring the Potential of Neural Networks in Aiding Radiologists with Brain Tumor Diagnosis via MRI Scans (Preprint)
Authors: Islam Samia , Jiang Xiaoqian
Published: September 2023

BACKGROUND

Computer aided diagnosis (CAD) systems, particularly neural networks, are gaining popularity in assisting in clinical diagnoses. Various neural network models have thus far been proposed that have the potential to aid radiologists with earlier brain tumor diagnosis from magnetic resonance imaging (MRI) scans. As with many other diseases, early detection of brain tumors can pave the way for more treatment options, thus impacting the outcome of the tumor.

OBJECTIVE

We aim to explore the use of neural networks by clinicians to aid in brain tumor diagnosis from MRI scans by reviewing articles presenting novel artificial intelligence (AI)-based models, particularly convolutional neural networks (CNNs), and highlighting strengths and limitations of current methods.

METHODS

We reviewed studies of novel CNN-based brain tumor diagnosis models from the PubMed database with respect to implementation details and performance of models.

RESULTS

The review identified several categories of CNN models: transfer learning, conventional CNN architecture with minor variations, and hybrid architecture. All models performed remarkably well when tested on brain MRI scan datasets, either to classify the presence/absence of brain tumor, or classification of the type of brain tumor.

CONCLUSIONS

In this paper, we present neural network-based models that were used to detect and/or classify various types of brain tumors with relative success. We provide details of the various models and highlight the strengths and limitations of current methods, demonstrating that the use of artificial intelligence in clinical decision making from imaging data holds promise and will continue to grow with advanced technological capabilities.
Vector-based seismic decomposition by reverse time methods
Authors: Agafonov Vadim , Bugaev Aleksandr , Erokhin Gennadiy , Ronzhin Andrey
Published: September 2023

The paper analyzes the stage of decomposition of the initial seismic data in the methods of wave reversal in time when constructing seismic attributes. Within the framework of the formal approach of mapping the data of one space into the data of a space of a higher dimension, a classification of existing approaches in seismic exploration is given. Identification of the decomposition stage in the seismic data processing workflow makes it possible to highlight the differences in existing approaches to building seismic attributes and predict the future direction of seismic data processing. The concept of vector decomposition, originally used in the RTH method, is introduced. The variety of depth seismic attributes obtained in the RTH method based on vector decomposition allows solving a wide range of problems in the exploration and development of hydrocarbon deposits at a new qualitative level. The RTH method includes, as a special case, the PSDM, AVO, AI methods and is an alternative to the MVA, FWI methods, as well as the method of a velocity model bilding based on fast beam migration algorithms. A close connection between the technique of wavefront time reversal in seismic exploration and analogous time reversal in optics and acoustics is noted. Examples of seismic data processing using vector decompositio to identify zones of natural fracturing in shale oil are given.
The Disorientation of the Political Capacity of Indonesian Pro-Democracy Activists
Authors: Samadhi Willy Purna
Published: September 2023

This study examines the political performance of pro-democracy activists in Indonesia after the end of the New Order. Using a democratic transformative politics approach, this study confronts aspects of the political capacity of pro-democracy activists with the need for popular control to work effectively. It finds that activists have been disoriented towards the development of political capacity and popular control. This study contributes to the study of Indonesian democracy by placing the issue of political capacity for building popular control as an integral part of the problem of democracy. The problems of democratisation are not only caused by the domination of political elites who have established oligarchies, but also by pro-democracy activists themselves ignoring the importance of developing collective political capacity as a means of advancing popular control. This study urges pro-democracy activists to re-orient their political capacity building and work with an agenda of consolidating the demos for civic democracy. Pro-democracy activists need to develop a systematic strategy of politicisation to strengthen citizens’ collective power through civic associations as a substitute forconstituents and voters.
Affective Factors and Pedagogical Implications in Young Learners’ English Learning
Authors: Guo Beixuan
Published: September 2023

The process of second language learning involves both objective and affective factors. Based on Krashen’s theory on affective filter, the present paper sets Chinese young English learners as a specific object and argues how to use affective factors in second language teaching to improve young learners’ engagement. By analyzing this topic, some useful results and implications have been found and can be used for future teaching by specific groups of teachers.
The World’s Wife’s Personas through the Psychoanalytic Lens: An Analysis of Mrs. Beast, Mrs. Lazarus, Mrs. Midas, Mrs. Quasimodo and Queen Herod
Authors: Alhgam Mohammed Yahya Sahib
Published: September 2023

This study aims to analyze the personas of The World’s Wife women. Carol Ann Duffy uses the Monologues to express the voice of the women who were kept silenced in history and myths, and each persona of this poem collection expresses her suffering and desires in a different manner which can be seen as unorthodox through the lens of the social norms. This study focuses on the individual personas as characters and their psychological disturbance. All of the personas face a troubling environment, which she has to face in a certain manner and behavior. Through this study, we can specifically locate the psychological disturbance of Mrs. Beast, Mrs. Lazarus, Mrs. Midas, Mrs. Quasimodo, and Queen Herod.
СОВРЕМЕННЫЙ БИЗНЕС ТРЕБУЕТ ГИБКОГО ПОДХОДА И СКОРОСТИ РЕАКЦИИ
Authors: Крупенин И.
Published: September 2023

«Новатор» – компания, которая занимается поставкой оборудования,
конструкционных, вспомогательных материалов, химических добавок
для производства печатных плат, а также внедряет технологии для
запуска производства. О ситуации на рынке поставщиков, бизнесе
в условиях сложной политической и экономической обстановки в мире и сотрудничестве с азиатскими компаниями рассказал Игорь Крупенин, коммерческий
директор АО «Новатор».
La regulación legal del convenio colectivo en España: orígenes y evolución
Authors: Goerlich Peset José María
Published: September 2023

El artículo examina el título III del Estatuto de los Trabajadores de 1980, que aborda la negociación y el convenio colectivo. Aunque inicialmente se optó por un modelo de convenio con una eficacia robusta, con ventajas evidentes, con el tiempo surgieron desafíos. Desde su implementación, se han realizado varias reformas al modelo original. Este estudio ofrece un resumen de dichas modificaciones y busca discernir si las cuestiones pendientes han sido resueltas de manera definitiva.
El derecho humano a la salud en Costa Rica
Authors: Arias Mora Freddy
Published: September 2023

Este artículo examina la conceptualización del derecho a la Salud en Costa Rica. Aunque no está explícitamente mencionado en la Constitución Política, ha sido definido y fortalecido por la jurisprudencia del Tribunal Constitucional costarricense. El estudio argumenta que este derecho debe ser visto como autónomo, progresivo y con una esencia definida, respaldándose en la legislación nacional y en decisiones de la Corte Interamericana de Derechos Humanos. Finalmente, se determina que en Costa Rica, el derecho a la salud es completamente exigible ante la justicia.
Aplicación e invocación del corpus iuris interamericano en las jurisdicciones reconocidas constitucionalmente en Bolivia
Authors: Franco Zamora Paul Enrique
Published: September 2023

El artículo aborda cómo en Bolivia, desde perspectivas jurídicas contemporáneas, se integran tanto el Derecho Local como el Supranacional, dada su participación en Tratados y Convenios Internacionales. Al resolver casos en sus jurisdicciones constitucionales, los operadores jurídicos no solo se apegan a la legislación nacional, sino que también recurren al marco legal interamericano, reflejando un compromiso con la protección de derechos. Este estudio ilustra cómo Bolivia incorpora normativas y jurisprudencias del Sistema Interamericano de Derechos Humanos en sus procesos judiciales, destacando las mejores prácticas en el control de convencionalidad en diversas áreas jurídicas.
La protección al consumidor de vivienda en Colombia. Reconocimiento de sus derechos en el Estatuto del Consumidor y el carácter supletivo de las normas civiles
Authors: Pacheco Ramírez Lizz Dahiam
Published: September 2023

El artículo destaca el crecimiento y relevancia del derecho del consumo en la actualidad. Antes abordadas desde el ámbito civil o comercial, muchas cuestiones ahora se analizan bajo la lente del consumidor, un sujeto que ha adquirido una importancia primordial. El Estatuto del Consumidor ha ido desplazando gradualmente a las normativas civiles y comerciales tradicionales. Un ejemplo palpable de este cambio se observa en el sector de la construcción, donde el consumidor de vivienda ha beneficiado de decisiones judiciales y administrativas que protegen sus derechos e intereses, consolidándolo como una figura central en la economía social de mercado.
Recurso de amparo y procedimiento legislativo: el polémico Auto 177/2022 del Tribunal Constitucional español
Authors: Requejo Rodríguez Paloma
Published: September 2023

El artículo analiza la decisión del Congreso español de admitir enmiendas para cambiar el proceso de renovación de Magistrados del Tribunal Constitucional, a pesar de no estar relacionadas con el tema principal de la proposición de ley. Esta situación llevó a un grupo de diputados a presentar un recurso de amparo, alegando una vulneración de sus derechos fundamentales. El Tribunal Constitucional, a través del Auto 177/2022, aceptó el recurso y paralizó temporalmente la tramitación de dichos artículos en el Senado. Esta acción generó debate: ¿Es una medida para prevenir daños irreparables o una interferencia del Tribunal en el proceso legislativo? El tema se convirtió en centro de una polémica en un contexto ya polarizado.
Structural Analysis of Three-Cell Box Culverts: A Study Considering Different S/H Ratios with Diverse Skew Angles
Authors: Mishra Akash , Pendharkar Dr. Umesh
Published: September 2023

Abstract: A crucial role is played by box culverts as vital structures, having been constructed in diverse forms and dimensions to meet a range of waterway and traffic requirements. A pathway beneath roads is offered, ensuring safe traversal without road traffic disruption, thus providing users with a secure journey. Typically, box culverts are utilized for this purpose. A variety of pressures from water, traffic, cushion, and soil are endured by these structures. In this paper to check the box culvert against various loads and alignment, 3 box cell culvert with 12 distinct cases have taken A2 to L2 having 4 sets of models of different S/H ratios 1.5, 1.75 and 2. In each sets, 4 combinations have taken of different skew angles viz. 0, 17, 34 and 51 degree respectively. After then these all 12 models have checked and efficient model under head of each degree and S/H noted. Finally, the result concluded that use skewness up to 17 degree with more S/H ratio to create an economic 3 cell box culvert.
A Review Article: Electro-Spinning Thin Film Nano-Spun Fibers
Authors: Deoghare Shravni , Devangan Bharat , Abdulhaq Ahesanulhaq , Tripathi Rupanshu , Chandekar Prachi , Kalsait Dr. Ravi , Wahi Harshpal Singh
Published: September 2023

Abstract: Electrospinning is an electron – hydrodynamic process which is gainful and flexible method. Electrospinning forms fibers in 100 NM ranges. Electrospinning mainly composed of 3 main components. High voltage, Spinners and Target collector plate. It is versatile and viable technique for ultra-thin fibers generation. Electrospinning is mainly because there is an increase in surface area compare to volume as particle get smaller. Nanotechnology accomplished most attraction by researcher a nanomaterial exhibit novel and significantly improve properties in terms of physical, chemical, biological, mechanical properties produced of electro spun nanofiber and they can be modified accordingly. Nanotechnology is a budding technology that has been identified as a vital scientific and commercial venture with global economic benefits.
RESTORATION OF KNIVES OF COMPOSITE PLOUGHSHARES (ON THE EXAMPLE OF THE COMPANY «LEMKEN»)
Authors: Mikhalchenkov A. M. , Shustov A. F. , Sinyaya N. V. , Leshchev M. O.
Published: September 2023

The orientation of Russian agriculture to the use of imported machinery has led to negative consequences. The introduction of sanctions by European states led to an increase in the market price of replaceable parts and an increase in scarcity. The way out of this situation is to organize workshops for the restoration of worn parts. (Research purpose) The research purpose is developing and describing in detail (with explanatory illustrative materials) the technological process of restoring knives of composite ploughshares. (Materials and methods) We have determined that it is necessary to ensure minimum economic costs; simplicity of operations; the ability to perform technology elements by low-skilled personnel; simplicity and availability of materials, tools, fixtures and equipment. (Results and discussion) The technological process was based on the method of repair inserts, which are welded to the knife instead of the worn area. Inserts can be made from discarded spring sheets having a hardness of about 45 on the Rockwell scale. It was established that the restoration process consists of three stages: preparation of the knife for restoration; preparation of the insert; restoration. They have shown that the technological process is simple, versatile, there is no need for complex equipment and can be implemented in enterprises with minimal technical equipment. It can be adapted to restore the knives of ploughshares of other companies. It was noted that this technology fits into the import substitution program. (Conclusions) The developed technology of restoration of knives of composite ploughshares of the Lemken company was presented in a text version and in illustrations. The technology is characterized by simplicity of execution, versatility and can be adapted for the repair of knives from other companies.
Forging quantum data: classically defeating an IQP-based quantum test
Authors: Kahanamoku-Meyer Gregory D.
Published: September 2023

Recently, quantum computing experiments have for the first time exceeded the capability of classical computers to perform certain computations – a milestone termed "quantum computational advantage." However, verifying the output of the quantum device in these experiments required extremely large classical computations. An exciting next step for demonstrating quantum capability would be to implement tests of quantum computational advantage with efficient classical verification, such that larger system sizes can be tested and verified. One of the first proposals for an efficiently-verifiable test of quantumness consists of hiding a secret classical bitstring inside a circuit of the class IQP, in such a way that samples from the circuit's output distribution are correlated with the secret. The classical hardness of this protocol has been supported by evidence that directly simulating IQP circuits is hard, but the security of the protocol against other (non-simulating) classical attacks has remained an open question. In this work we demonstrate that the protocol is not secure against classical forgery. We describe a classical algorithm that can not only convince the verifier that the (classical) prover is quantum, but can in fact can extract the secret key underlying a given protocol instance. Furthermore, we show that the key extraction algorithm is efficient in practice for problem sizes of hundreds of qubits. Finally, we provide an implementation of the algorithm, and give the secret vector underlying the "\$25 challenge" posted online by the authors of the original paper.
LIMDD: A Decision Diagram for Simulation of Quantum Computing Including Stabilizer States
Authors: Vinkhuijzen Lieuwe , Coopmans Tim , Elkouss David , Dunjko Vedran , Laarman Alfons
Published: September 2023

Efficient methods for the representation and simulation of quantum states and quantum operations are crucial for the optimization of quantum circuits. Decision diagrams (DDs), a well-studied data structure originally used to represent Boolean functions, have proven capable of capturing relevant aspects of quantum systems, but their limits are not well understood. In this work, we investigate and bridge the gap between existing DD-based structures and the stabilizer formalism, an important tool for simulating quantum circuits in the tractable regime. We first show that although DDs were suggested to succinctly represent important quantum states, they actually require exponential space for certain stabilizer states. To remedy this, we introduce a more powerful decision diagram variant, called Local Invertible Map-DD (LIMDD). We prove that the set of quantum states represented by poly-sized LIMDDs strictly contains the union of stabilizer states and other decision diagram variants. Finally, there exist circuits which LIMDDs can efficiently simulate, while their output states cannot be succinctly represented by two state-of-the-art simulation paradigms: the stabilizer decomposition techniques for Clifford + T circuits and Matrix-Product States. By uniting two successful approaches, LIMDDs thus pave the way for fundamentally more powerful solutions for simulation and analysis of quantum computing.
Noise-robust ground state energy estimates from deep quantum circuits
Authors: Vallury Harish J. , Jones Michael A. , White Gregory A. L. , Creevey Floyd M. , Hill Charles D. , Hollenberg Lloyd C. L.
Published: September 2023

In the lead up to fault tolerance, the utility of quantum computing will be determined by how adequately the effects of noise can be circumvented in quantum algorithms. Hybrid quantum-classical algorithms such as the variational quantum eigensolver (VQE) have been designed for the short-term regime. However, as problems scale, VQE results are generally scrambled by noise on present-day hardware. While error mitigation techniques alleviate these issues to some extent, there is a pressing need to develop algorithmic approaches with higher robustness to noise. Here, we explore the robustness properties of the recently introduced quantum computed moments (QCM) approach to ground state energy problems, and show through an analytic example how the underlying energy estimate explicitly filters out incoherent noise. Motivated by this observation, we implement QCM for a model of quantum magnetism on IBM Quantum hardware to examine the noise-filtering effect with increasing circuit depth. We find that QCM maintains a remarkably high degree of error robustness where VQE completely fails. On instances of the quantum magnetism model up to 20 qubits for ultra-deep trial state circuits of up to 500 CNOTs, QCM is still able to extract reasonable energy estimates. The observation is bolstered by an extensive set of experimental results. To match these results, VQE would need hardware improvement by some 2 orders of magnitude on error rates.
Atomic Structure and Its Connection to The Quranic Verses' Context
Authors: Mujala Abdul , Reza Muhammad , Puspita Kana
Published: September 2023

Abstract: The growth of science in the twenty-first century, particularly in chemistry, is critically dependent on the integration of science and the Qur'an. Since numerous verses in the Qur'an disclose the fundamental principles of chemistry, such as the size of an atom, the integration of science and the Qur'an is nothing new in modern science, especially chemistry. As a result, this article will go into further detail regarding the atomic structure's physical setting and how it relates to Qur'anic verses. Writing this paper involved conducting literature searches on both contemporary science and Qur'anic interpretations of atomic structure. The word "dzarrah" appears in QS Az-Zalzalah verses 7-8, An-Nisa verse 40, and Yunus verse 61, and is interpreted as the size of a mustard seed that the human intellect may yet attain. However, "dzarrah" is often frequently interpreted as atomic size, since the atomic radius of the smallest atom (Hydrogen) and biggest atom (Organesson) atoms are 1.2 x 10-10 m and 1.52 x 10-10 m, respectively, with 1 million being smaller than the radius of mustard seed (5 x 10-4 m). Thus, the word dzarrah, which is translated as the size of a mustard seed, is less proportional to describe a much smaller atomic size. This atomic scale later served as a precursor for new developments in chemical research, such as nanomaterials and quantum dots.Abstrak: Integrasi sains dan Al-Qur’an menjadi dasar yang penting untuk pengembangan ilmu sains pada abad ke-21, khususnya dalam ilmu kimia. Integrasi sains dengan Al-Qur’an sebetulnya bukanlah hal baru dalam sains modern, khususnya kimia, karena ada banyak ayat-ayat Al-Qur’an yang mengungkapkan tentang konsep dasar kimia, misalnya ukuran atom. Oleh karena itu, artikel ini akan membahas secara lebih jelas tentang konteks materi struktur atom dan kaitannya dengan ayat-ayat Al-Qur’an. Metode penulisan artikel ini menggunakan kajian literatur, baik itu dari segi sains modern dan tafsir Al-Qur’an tentang struktur atom. Kata “dzarrah” muncul dalam QS Az-Zalzalah ayat 7-8, QS An-Nisa ayat 40, dan QS Yunus ayat 61, yang ditafsirkan seukuran biji sawi yang ukurannya masih dapat dijangkau oleh pikiran manusia. Namun, “dzarrah” juga kerap diterjemahkan seukuran atom, padahal jari-jari 1 atom paling kecil (Hidrogen) dan paling besar (Organesson) berturut-turut adalah 1,2 x 10-10 m dan 1,52 x 10-10 m, dimana 1 juta lebih kecil dari jari-jari biji sawi (5 x 10-4 m). Sehingga kata dzarrah yang diterjemahkan sebagai ukuran biji sawi kurang proporsional untuk menggambarkan ukuran atom yang jauh lebih kecil. Ukuran atom ini kemudian menjadi cikal bakal perkembangan penelitian di bidang kimia, misalnya nanomaterial dan quantum dots.
Teleconsultation During COVID-19 Pandemic in Chennai, India: A Cross- Sectional Study
Authors: Grace G Angeline , NB Swetha , Gour Rashmi , R Umadevi , P Sujitha
Published: September 2023

During the COVID-19 pandemic, people hesitate to visit hospitals for consultation, treatment, and follow-up. Theavailability of advanced technologies, like teleconsultation, helps people continue their access to healthcare, consult doctors fortheir symptoms, and get treated. Few studies have been done in Tamilnadu to assess people's experience in accessing healthcarethrough a teleconsultation approach. As the pandemic is ongoing, it is imperative to assess the quality of healthcare and patientsatisfaction with teleconsultation services. With the above background, this study was done to assess the patient's experience inthe use of teleconsultation during the COVID-19 pandemic in Chennai, Tamilnadu. The study's objectives were to determine theattitude towards the use of teleconsultation and to describe the quality of healthcare provided through this method. This studywas done among residents in the city of Chennai, Tamilnadu. Individuals aged 18 years and above, residing in Chennai, and had atleast one teleconsultation during the COVID-19 pandemic were included. Data were collected by an online, self-administeredquestionnaire disseminated through various social media platforms. Data were entered in Microsoft Excel and analyzed in Epiinfo. Among 405 study respondents, 61.2% were males. The mean age of the respondents was 34.6 years. Nearly 95.6% agreedthat teleconsultation services have made access to healthcare easier during the pandemic. Around 92.1% were satisfied with thequality of healthcare through teleconsultation. About 55.3% said they paid more for online consultation when compared todirect consultation. Among 92.6% of participants who were advised a follow-up consultation, only 52% completed the follow-up.About 90% still preferred direct consultation with healthcare providers in the future. Though many participants felt thatteleconsultation services improved access to healthcare during the pandemic, they still wished to contact healthcare providersdirectly in the future.