bluuebunny/crossref_metadata_2025 huggingface dataset:
Large-Scale Deployment of Lehmann’s Funnel Entry Traps to Control Malaria Mosquito Populations
Authors: Maïga Hamidou , Sanou Roger , Sow Bazoumana B. D. , Ouema Adama , Millogo Abdoul Azize , Bayili Koama , Hien Aristide Sawdetuo , Sawadogo Simon P. , Millogo Souro Abel , Belem Adrien Marie Gaston , Toé Léa Paré , Dabiré Roch K. , Diabaté Abdoulaye
Published: February 2025

Effective tools to prevent mosquito bites are essential for malaria control. The Lehmann Funnel Entry Trap (LFET), a window screen proven effective in reducing mosquito density, was tested for its large-scale impact on malaria vector control and community acceptance. A total of 1313 traps were deployed in Vallée du Kou 3 (VK3), with 12 traps randomly selected for detailed evaluation against untrapped houses in Vallée du Kou 5 (VK5). Traps were placed in windows with doors blocked by curtains. From July to October, mosquitoes were collected for nine days per month from VK3 traps and VK5 control houses. Morphological identification, density analysis, resistance gene screening, and female age structure determination were conducted. The trap’s impact was assessed via pyrethrum spray catch (PSC) and for nine days per month, while trap fabric integrity and community perceptions were also evaluated. Traps reduced mosquito entry density by more than 90% in VK3 houses. VK3 had 33% higher house mosquito density pre-intervention and 47% lower house mosquito density post-intervention than VK5. Old female mosquito numbers rose in VK5 but not VK3. Pyrethroid resistance was high (kdr mutation frequency > 0.9) in both control and intervention sites. VK3 residents appreciated the traps for reducing bites and improving sleep. The LFET effectively controls malaria vectors and is well-suited for widespread use in malaria elimination efforts.
Prevalence of Adverse Events Reported Following the First Dose of COVID-19 Vaccines in Bahia State, Brazil, from 2021 to 2022
Authors: Saavedra Ramon da Costa , Paixao Enny S. , Ichihara Maria Yury Travassos , Costa Maria da Conceição Nascimento , Carvalho-Sauer Rita , de Castro Caroline Tianeze , Teixeira Maria Gloria
Published: February 2025

Background: Despite adverse events following immunization (AEFI) being well described in vaccine trials, there is a need to produce more real-world data on events supposedly attributed to vaccination against COVID-19. This study aims to estimate the prevalence of AEFI in the first dose of COVID-19 vaccines in the state of Brazil and to verify whether such events differ among the types of vaccines offered in this country. Methods: A population-based study using linked administrative data on vaccine registry and adverse events following immunization in 2021 and 2022. The study included 10,169,378 individuals aged 18 or over who lived in Bahia and received the first dose of COVID-19 vaccines. We calculated AEFI prevalence and verified differences among vaccines by logistic regression to estimate crude and adjusted by sex and age group prevalence ratio (PR). Results: The prevalence of AEFI was 74.3 per 100,000 doses applied, with a higher rate of nonserious events, mainly following the ChAdOx1-S. More than two-thirds of these adverse effects occurred in women, and almost half were between 30 and 49 years old. The individuals who received ChAdOx1-S had a 125% higher prevalence than those who received CoronaVac. Those who received BNT162b2 and Ad26.COV2.S had a 71% and 58%, respectively, lower prevalence of AEFI than those who received CoronaVac. Conclusions: The use of vaccines against COVID-19 has proven to be positive and effective in combating SARS-CoV-2, significantly reducing morbidity and mortality from the disease. We cannot deny the presence of adverse events in the context of vaccination. However, the vaccines have proven to be safe and reliable. The results of this study offer relevant data that can contribute to the qualification of AEFI pharmacovigilance in Brazil and worldwide.
Longitudinal Surveillance of COVID-19 Antibodies in Pediatric Healthcare Workers
Authors: Hatabah Dunia , Gupta Sneh Lata , Mantus Grace , Sullivan Patrick , Heilman Stacy , Camacho-Gonzalez Andres , Leake Deborah , Le Mimi , Griffiths Mark , Norwood Carson , Shih Samuel , Korman Rawan , Maziashvili Giorgi , Rees Chris A. , Benedit Laura , Wynn Bridget A. , Suthar Mehul , Vos Miriam B. , Wrammert Jens , Morris Claudia R.
Published: February 2025

Background: Vaccines against COVID-19 target the spike protein. There is minimal information on longitudinal COVID-19 immune profiling in recovered versus naïve and vaccinated versus non-vaccinated healthcare workers (HCWs). Methods: This is a prospective longitudinal observational cohort of pediatric HCWs (pHCWs) conducted during 2020–2022 at an academic center, exploring the impact of COVID-19 vaccination on immunoglobulin G (IgG) antibody titers over time and cross-reactivity with other coronaviruses, including SARS-CoV-1, MERS-CoV, and seasonal coronaviruses (HCoV-HKU1 and HCoV-OC43). Results: A total of 642 pHCWs initially enrolled, and 337 participants had repeat IgG titers measured post-vaccine and post-booster. Most participants were female, median age range of 31–40 years. Anti-spike was higher in all vaccinated individuals versus non-vaccinated (p < 0.0001) and naïve versus infected (p < 0.0001). A single dose of vaccine was sufficient to attain maximum titers in recovered participants versus naïve who received both doses of vaccine. Anti-spike titers dropped significantly at 9 months after the primary series, whereas sustained anti-spike titers were observed at 9 months post-booster. Conclusions: All vaccinated pHCWs developed antibodies to spike. COVID-19 infection and/or vaccination yielded antibodies that cross-reacted to SARS-CoV-1, MERS-CoV, HCoV-HKU1, and HCoV-OC43. Anti-spike titers were more durable post-booster compared to the primary series. Longitudinal immune profiling of COVID-19 responses provides vital data to shape public health policies, optimize vaccine strategies, and strengthen pandemic preparedness.
Photocatalysis-Assisted Water Remediation Using Porous Nanowire Foams
Authors: Yanda Bhupesh Pydiraju , Panchagnula Dharani Sathwik Ram , Gentry Terry J. , Vaddiraju Sreeram
Published: February 2025

Deployment of photocatalysis for water disinfection necessitates engineering the process kinetics and achieving the complete recovery of the photocatalyst following the remediation of water. The recovery of the photocatalysts, especially nanostructured photocatalysts, remains a challenge, as indicated by a previous study by our group where only 57% of TiO2 nanowires were recovered by gravity-assisted settling and sedimentation from water after its photocatalysis-assisted E. coli inactivation. To overcome this challenge, a novel method involving the use of photocatalysts in the form of porous foams is developed and presented. Use of TiO2 nanowire foams led to a 2–3-log reduction of E. coli in a span of 180 min when ultraviolet-A (UV-A) light was employed for photoactivation, similar to that observed previously by our group. More importantly, the photocatalyst foams were easily recoverable from water via mechanical separation using tweezers, which in this study led to a recovery of 98–99% of the TiO2 nanowire photocatalysts. This strategy allows for further optimization of both the process kinetics and the total amount of photocatalysts needed for water remediation through optimization of the porosities and the geometries of the foams and ensuring that all the photocatalyst surfaces remain accessible to both the pollutants and light.
Impact of Spatiotemporal Rainfall Distribution and Underlying Surface Changes on Flood Processes in Meijiang River Basin, China
Authors: Lu Xiangyu , Wen Tianfu , Zhang Linus , Zhang Qi
Published: February 2025

This study reports on the impact of rainfall patterns and land surface changes on flood dynamics in the Meijiang River Basin, located in the upper reaches of the Ganjiang River. We formulated a range of rainfall patterns and spatial distribution scenarios and employed the MIKE SHE model to evaluate variations in flood volume, flood peak, and the timing of flood peaks. We found that under comparable areal rainfall conditions, flood volumes fluctuated by up to 6.22% among the different rainfall patterns, whereas flood peaks exhibited differences of up to 36.23%. When the rainfall center moved from upstream to downstream, both flood volume and flood peak initially increased before decreasing, with maximum values of 4.2 billion m3 and 4900 m3/s, respectively. We selected three basin scales (i.e., 10,000, 1000, and 100 km2) for comparative analysis. In the period between 1985 and 2020, the changes in land surface conditions resulted in decreases in the flood peaks of the three basins by 7.61, 11.53, and 15.79%, respectively; a reduction in the flood volumes of the three basins by 6.58, 9.60, and 10.48%, respectively; and delayed peak times by 3, 2, and 2 h, respectively. The results of this study show the significant influence exerted by rainfall patterns, the location of the rainfall centers, and the impact of changes in land surface conditions on flood processes. In particular, when the area of the basin was reduced, the influence of the underlying surface was more obvious. These results also show that flood prediction needs to consider the complex interaction of multiple factors.
Capacidad antioxidante y contenido fenólico total del extracto acuoso del tallo de matico (buddleja globosa)
Authors: Zamorano-Aguilar Pedro , Seperiza Wittwer Astrid , Bustos Cerda Rubén , Rojano Benjamín
Published: February 2025

Buddleja globosa (matico) es una planta medicinal nativa de Chile, ampliamente reconocida por las propiedades terapéuticas de sus flores y hojas. Sin embargo, su tallo ha sido poco explorado y generalmente descartado, a pesar de su potencial como fuente de compuestos bioactivos. El objetivo de este estudio fue investigar la concentración de polifenoles y la capacidad antioxidante del tallo de esta planta medicinal. Se cuantificaron compuestos bioactivos, como fenoles totales, flavonoides, vitamina C y catequina. La capacidad antioxidante se evaluó mediante las metodologías ABTS, DPPH y ORAC-H. Los resultados mostraron una elevada concentración de polifenoles totales (2749,78 mg de ácido gálico/100 g PS), flavonoides (2096,53 mg de catequina equivalente/100 g PS) y una significativa capacidad antioxidante en los ensayos ORAC-H (35661,73 ?mol Trolox equivalente/100 g PS), ABTS (13404,39 ?mol Trolox equivalente/100 g PS) y DPPH (8268,45 ?mol Trolox equivalente/100 g PS). Estos hallazgos destacan el valor del tallo de Matico como una rica fuente de compuestos bioactivos. Este es el primer reporte sobre la composición del tallo de Buddleja globosa, sugiriendo que partes de la planta comúnmente descartadas poseen un alto potencial para el desarrollo de productos antioxidantes y terapéuticos.
Efecto del manitol y sorbitol en la conservación in vitro de Solanum tuberosum L.
Authors: Montalvo Otivo Jorge Manuel , Flores Miranda Candelaria , Mancilla Condor Juan Luis , Carbajal Cuadros Leonor Neda , Leon Gomez Rodolfo
Published: February 2025

La conservación in vitro supera limitaciones de métodos convencionales, ofreciendo plantas libres de patógenos con mayor uniformidad genética. El propósito de la presente investigación fue evaluar el efecto de diferentes concentraciones de manitol y sorbitol en el desarrollo de los microtubérculos producidos a partir de explantes in vitro de Solanum tuberosum L., con el fin de optimizar las condiciones para su conservación. Se diseñó un experimento completamente aleatorizado con arreglo factorial, que incluyó tres niveles de concentración, 0%, 2% y 4%, de ambos agentes osmóticos. Los hallazgos indican que concentraciones bajas, 2%, de manitol y sorbitol favorecieron un crecimiento moderado de los explantes como osmoprotectores. Sin embargo, al 4% se observó una disminución significativa en el desarrollo por estrés osmótico excesivo. La interacción entre ambos agentes a altas concentraciones tuvo un efecto sinérgico negativo en el crecimiento. Este estudio resalta la importancia de optimizar manitol y sorbitol en cultivos in vitro para ralentizar el crecimiento sin toxicidad y conservar el germoplasma.
The Impact of SGLT2 Inhibitors and GLP-1 Receptor Agonists on 24-hour Urine Parameters
Authors: Schaub Jennifer A. , Oerline Mary K. , Crivelli Joseph J. , Maalouf Naim M. , Best Sara L. , Asplin John R. , Hollingsworth John M. , Shahinian Vahakn , Hsi Ryan S.
Published: February 2025

Background:

Emerging data suggest sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1-RA) may lower stone risk.

Methods:

We characterized 24-hour urine parameters among individuals with kidney stone disease receiving these agents using Medicare claims from beneficiaries with urine collections processed by a central laboratory between January 2010 and December 2019. We identified a cross-sectional cohort with diabetes and a prescription fill for SGLT2i or GLP-1RA within the six months preceding their urine collection and matched controls. We additionally identified a subset of patients who performed two collections and had a prescription fill for SGLT2i or GLP-1RA before the second collection, but not the first. We compared across 24-hour urinary parameters in both cohorts and adjusted for multiple comparisons.

Results:

The cross-sectional cohort included 124 patients with a prescription fill for SGLT2i (and 620 matched controls), and 349 patients with a prescription fill for GLP-1RA (and 349 matched controls). Compared to controls, patients on SGLT2i had a higher mean urine citrate (838 mg vs. 636 mg; p<0.01) and volume (2.4L vs. 2.0 L; p<0.01) with improved calcium phosphate supersaturation (p<0.01). Lower urine pH and higher sulfate, and uric acid were observed in the SGLT2i group (p<0.01 for each). There were no significant differences in urine parameters with GLP-1RA. In the longitudinal analyses of SGLT2is (59 patients) and GLP-1RAs (154 patients), there were no significant differences in urinary parameters.

Conclusions:

SGLT2is were associated with higher urine volume and citrate in a cross-sectional cohort. GLP-1RA were not associated with changes that would reduce stone risk.
Peritoneal Dialysis Patient Transfers to Hemodialysis
Authors: Adoukonou Nanti E. , Boyer Annabel , Lobbedez Thierry , Bechade Clémence , Lanot Antoine
Published: February 2025

Background:

The end of peritoneal dialysis (PD) can be marked by kidney transplantation, death, or transfer to hemodialysis (HD). We compared the risks of the different reasons for transfer to HD in PD patients according to the use of assistance for PD care, PD modality, and the suboptimal starter status.

Methods:

This was a retrospective study using data from the French Language Peritoneal Dialysis Registry from patients who started PD between January 1, 2002, and December 31, 2018. We used Cox and Fine Gray survival models to evaluate the risks of transfer to HD due to PD inadequacy, infection, mechanical issue, psychosocial issue, others PD-related and others non-PD-related causes. Models were evaluated for three periods of PD vintage: 0 to 6 months, 6 to 18 months, and after 18 months.

Results:

The study included 15,974 incident PD patients treated in 170 French PD units. There were 6,835 deaths, 5,108 transfers to HD and 3,092 renal transplantations. Nurse-assisted PD was associated with a lower risk of transfer to HD for infection in the first 18 months (cs-HR 0.51, 95%CI 0.31-0.83 before 6 months) and for adequacy issues after 6 months (cs-HR 0.59, 95%CI 0.51-0.70 after 18 months). The risk of transfer for mechanical issue was higher in CAPD compared to APD during the first eighteen months (cs-HR 1.41, 95%CI 1.00-1.99 before 6 months), but CAPD was associated with a lower risk for adequacy, infectious or mechanical issue after 18 months. Finally, suboptimal starters have a higher risk of transfer due to psychosocial challenges in the first 6 months (cs-HR 1.70, 95%CI 1.03-2.81).

Conclusions:

Distinct factors are associated with the risk of transfer from PD to in-center HD, according to the cause of the transfer. Some preventive measures targeting these risk factors may help to maintain patients in PD.
Uso estético e terapêutico da toxina botulínica tipo A: relato de caso
Authors: Martins Lídia Batista Conrado , Mattos Thiago Borges , Filho Francisco Cerdeira , Sinhoroto Karina Cazetta , Tavares Luciana Claúdia Diniz , Souza Renan Abdallah Alves de , Viana Alexandro de Oliveira , Magri Ramira
Published: February 2025

Objetivo: descrever a aplicabilidade e funcionabilidade da toxina botulínica tipo A mediante parâmetros estéticos e terapêuticos através da descrição de casos clínicos com diferentes nuances. Detalhamentos de Caso: Paciente do gênero feminino, 31 anos, diagnosticado com Paralisia de Bell procurou atendimento odontológico por sequelas crônicas na hemiface, levando a assimetria facial. Pacientes de ambos os gêneros,  56, 37, 30 , apresentaram alta tonicidade em grupos musculares específicos do terço superior e inferior resultando em rugas dinâmicas expressivas e assimetria em subunidades faciais.. A técnica consistiu na aplicação intradérmica com reconstituição 100U/2ml, com raio de ação local de 1cm dentro da variação de 20 e 40mm do ponto de injeção. Conclusão: Resultados satisfatórios, seguros e eficientes foram obtidos mediante a aplicação de pontos complementares, com dosagens individualizadas intradérmicamente e intramuscularmente, visando a previsibilidade dos resultados.
PENGARUH DESTINATION IMAGE TERHADAP REVISIT INTENTION MELALUI MEMORABLE TOURISM EXPERIENCE DAN TOURIST ENGAGEMENT WISATAWAN TRANS STUDIO DI KOTA BANDUNG
Authors: Gina Melati Ramdini  , Abdul Ahmad Hafidh Nurmansyah
Published: February 2025

This study aims to analyze the influence of destination image on revisit intention through memorable tourism experience and tourist engagement of Trans Studio Bandung tourists. The population of this study is male and female tourists living in the city of Bandung with a convenience sampling method to collect samples. The respondents are tourists aged 17-64 years who have visited Trans Studio Bandung at least 1 time in the last 2 years. The number of samples used in this study was 120 respondents. Data was collected through google forms based on the Likert scale, and simple regression analysis, multiple, and sobel tests were carried out. The results of the study show that destination image has a positive effect on the memorable tourism experience. Destination image, and memorable tourism experience have a positive effect on tourist engagement. Revisit intention is influenced by destination image, memorable tourism experience, and tourist engagement. Memorable tourism experience is able to mediate the influence of destination image on tourist engagement and revisit intention. Tourist engagement mediates the influence of destination image and memorable tourism experience on revisit intention. This research is expected to be beneficial for further research, as well as provide important insights for the development of artificial tourism in increasing revisit intention.
PENGARUH LITERASI KEUANGAN, FINTECH PAYMENT DAN PERILAKU KONSUMTIF TERHADAP PERILAKU PENGELOLAAN KEUANGAN PRIBADI GENERASI Z DI JAWA BARAT
Authors: Risma Yulia Citra  , Esi Fitriani Komara
Published: February 2025

This study aims to examine more deeply the influence received by Gen Z Financial Behavior in West Java from financial literacy, fintech payments, and consumptive behavior. This study uses a quantitative approach with a descriptive and associative approach. The researcher used Google Form to collect primary data obtained by distributing questionnaires. The population studied is generation Z in West Java as many as 16,113,985 people, with a sample taken as many as 100 from 18 cities/regencies using simple random sampling. The collected data was analyzed by Multiple Linear Regression. It was found that financial literacy, fintech payment, and consumptive behavior each had a positive effect on personal financial management behavior and simultaneously financial literacy, fintech payment, and consumptive behavior had a positive effect.
A Study on the Meaning of ‘Effective IRB Review’ and ‘Efficiency of IRB Review Process’
Authors:   Catholic Institute of Bioethics, Cho Young Hoon , Choe Byung In
Published: February 2025

In modern times, changes in the research environment and an increase in the amount of research have led to an increase in IRB workload. This resulted in delays in research and burdens on researchers. Based on this background, the 'IRB efficiency issue' emerges. However, considering that the IRB system is an ethical system related to the safety and welfare of human subjects, the meaning of 'efficiency' rather than 'effectiveness' of IRB seems ambiguous.
Therefore, this study examined the meaning of 'efficiency' and 'effectiveness' of IRB and discussed the meaning of 'efficiency' that should be reconsidered in the IRB system based on this. At the same time, it proposed a direction for improving 'effectiveness' that should be considered first in the IRB system.
This study constitutes the meaning of 'efficiency' and 'effectiveness' of the IRB system by reviewing the process of revising the US Common Rule, policy cases related to IRB, and the Belmont Report and laws. In addition, based on this, it attempts to clarify its meaning through interview with domestic IRB stakeholders.
The meaning of IRB's 'efficiency' and 'effectiveness' and the discussion that emerged as a result of the interview were able to reflect on the additionality of IRB efficiency. In addition, suggestions for enhancing the effectiveness of the IRB system and creating an ethical environment for research could be made.
Bioethical Analysis of the EU AI Act : Implications and Challenges for AI Regulation in South Korea
Authors:   Catholic Institute of Bioethics, Yoo Sung Hee
Published: February 2025

This study analyzes the impact of artificial intelligence (AI) advancements on bioethical principles, particularly through a comparative examination of the EU AI Act and South Korea's AI regulations. While AI technology has driven significant innovation across various sectors such as healthcare, law, and public policy, it has also introduced numerous ethical challenges, including data bias, lack of explainability, and unclear legal accountability. These issues pose potential risks to fundamental human rights, necessitating a regulatory approach grounded in bioethical principles.
The EU AI Act presents a comprehensive legal framework aimed at addressing these ethical concerns by strictly regulating high-risk AI systems. It seeks to protect ethical principles like autonomy, justice, and non-maleficence through enforceable legal measures. In contrast, South Korea’s AI regulations primarily rely on non-binding guidelines, lacking the legal force and specificity seen in the EU's approach. This study critically examines these regulatory differences and proposes ways for South Korea to enhance its AI regulatory framework by incorporating the strengths of the EU AI Act.
The findings highlight the need for South Korea’s AI regulations to develop a more robust and specific legal framework that integrates bioethical standards, focusing on controlling data bias, enhancing explainability, and clarifying legal accountability. This includes establishing clear definitions and stringent regulations for high-risk AI systems, along with legally mandated transparency and explainability requirements. Such regulatory advancements would ensure that AI technology protects human dignity and fundamental rights while promoting innovation.
By providing a thorough analysis of the complex interplay between AI technology and bioethics, this study outlines the future direction for AI development and regulatory policies. Ongoing improvements in AI regulation and continuous research are essential to ensure that AI technology evolves in a way that positively impacts human society.
Problems of Understanding Property Rights in the Legal Literature of the Period of the Russian Empire
Authors:   Pushkin Leningrad State University, Saint Petersburg, Russian Federation, Tahmazidi I.I.
Published: February 2025

The history of the development of property rights in the Russian Empire is an important component of the study of the evolution of society and the state. The formation of the institution of property rights in Russian civil law in various periods of our history had its own characteristics and was characterized by a multidirectional development during the Soviet period. Property law is a key element not only for legal science, but also for economic and social theory. As part of the research, we will rely on the works of Russian scientists in the field of history and law, such as V. I. Vishnyakov, I. A. Pokrovsky, G. F. Shershenevich and others. This approach will allow us to better understand the historical and theoretical aspects of the development of property rights, as well as analyze its impact on modern legal structures.
Sovereign and Sovereignty Within the Framework of Carl Schmitt’s Juridical Decisionism
Authors:   Russian State University for the Humanities, Moscow, Russian Federation, Antonov B.A.
Published: February 2025

The author of the article attempts to analyze the concepts of sovereign and sovereignty in their retrospective and current interpretation. A retrospective analysis of both concepts involves an appeal to European medieval history (and in particular to the Holy Roman Empire), considered by the author from the position of legal decisionism of Carl Schmitt (1888-1985). The current interpretation comes down to the need to rethink the concept of sovereignty and problematize the consideration of this phenomenon from the point of view of its completeness. The purpose of the article is to analyze the concepts of sovereign and sovereignty in relation to the medieval history of the First Reich and to substantiate the relevance of these concepts within the framework of the theory of decisionism created by Schmitt. The article provides a brief excursion into the history of the struggle for the power of an absolute sovereign (using the example of the First Reich); the assessment of the concepts of sovereign and sovereignty given by Schmitt within the framework of his theory of decisionism is analyzed; The reasons for rethinking the traditiona
Sources of Regulatory Regulation of BRICS Activities
Authors:   North-­West Institute of Management of the RANEPA, Saint Petersburg, Russian Federation, Glushakov A.Y. , Sobolevskaya A.I. ,   Saint Petersburg State University of Industrial Technologies and Design, Saint Petersburg, Russian Federation
Published: February 2025

The relevance of the article is related to the actively developing commonwealth of the five BRICS member states and the need for its legal regulation, which is based on both international and national legislation with its own characteristics. As a result of the conducted research, the features of the legal regulation of the BRICS member countries related to their entry into different legal systems, issues of codification of legislation and the use of precedent as a source of law are analyzed. The sources of regulatory regulation of BRICS activities are considered and it is proved that due to the lack of international legislation regulating the activities of BRICS, legal regulation is carried out on the basis of national legislation, which needs harmonization. The result of the study was a proposal on the need to find a balance in a combination of legal norms of international and national legislation in regulating the activities of BRICS and the development of model regulatory legal acts.
CLASSIC BOOK, IS IT STILL RELEVANT? AN IN-DEPTH STUDY OF ADABUL ALIM WAL MUTA'ALLIM CONTENT TO TEACHER AND STUDENT INTERACTIONS IN CONTEMPORARY ERA
Authors: Yuni Maulida Anis , Muqit Abd. , Luqna Hunaida Wiwin , Fajrus Surur Muhammad
Published: February 2025

This research is driven by the interaction between teachers and students in the contemporary era, which is associated with the content of the book Adabul Alim wal Muta'allim. For instance, the disappearance of etiquette, both between teachers and their students and vice versa. In the contemporary era, this seems to be considered irrelevant to the contents of the book Adabul Alim wal Muta'allim, possibly due to cultural influences and the surrounding environment. In this contemporary era, most teachers and students do not often study the book Adabul Alim wal Muta'allim and lack an understanding of what a teacher and a student should ideally do. This aspect is essential for researchers to investigate, aiming to understand the reasons why the interaction between teachers and students in this contemporary era is considered irrelevant to the contents of Adabul Alim wal Muta'allim. The method used is library research, collecting data in the form of documentation, such as documents from various sources like journals, theses, and websites, which are gathered and observed for careful selection. The conclusion drawn from this research is that the interaction between teachers and students in the contemporary era is not yet considered relevant to the content of Adabul Alim wal Muta'allim. This could potentially lead to further research on how the content of Adabul Alim wal Muta'allim could become relevant to education, especially in terms of teacherstudent interactions
DYNAMIC TRANSFORMATION OF ISLAMIC RELIGIOUS EDUCATION CURRICULUM IN INDONESIA
Authors: Nida Sofwatun , Rafiqie Musyaffa , Mashuri Saepudin , Setyaningrum Putri Nadha , Abdullah Sagran Arif
Published: February 2025

Changes in the Islamic Religious Education curriculum are undeniable in Indonesia. The changes are in line with the development of the national curriculum in general. There are many articles about the development of the Islamic Religious Education curriculum in Indonesia, but all of them are protracted on the development of the national curriculum in general. This article aims to describe the characteristics of Islamic Religious Education in particular that have not been touched upon by previous articles. This literature research was carried out by reviewing articles and books on the development of the national curriculum and specifically about the Islamic Religious Education curriculum. Triangulation is carried out between one reference and another, classified according to sub-subjects, and finally conclusions are drawn. The results of the study show that there are five periods of changes in the Islamic Religious Education curriculum, namely the Pre-Independence Era when Islamic Religious Education materials were not found in schools, the ‘Orde Lama’ Era Islamic Religious Education lessons were optional at the request of the students' parents, the ‘Orde Baru’ Era Islamic Religious Education lessons gained a proportional position and portion, the Reform Era did not change but the forerunners of change were quite visible. In the New Indonesia era, the change in the Islamic Religious Education curriculum was very dynamic and this lesson became the spirit of all other subjects in K.13.
Kahramanmaraş (Türkiye) İli Monokotil Petaloid Geofitleri
Authors: Kocabaş Yusuf Ziya , İlçim Ahmet
Published: February 2025

Bu çalışma Kahramanmaraş ilinde doğal olarak yayılış gösteren monokotil petaloid geofit taksonlarını tespit etmek amacıyla yapılmıştır. Çalışma sonucunda alanda 10 familya ve 34 cinse ait 170 petaloid geofit takson tespit edilmiştir. Bu taksonların; 39’u Doğu Akdeniz, 36’sı İran-Turan, 18’i Akdeniz, 4’ü Avrupa-Sibirya fitocoğrafik bölge elementidir. Bu geofit taksonların 40’ı endemik olup endemizm oranı % 23.52’dir. En fazla geofit taksonla temsil edilen familyalar sırasıyla; Amaryllidaceae (42), Asparagaceae (37), Orchidaceae (27), Iridaceae (21), Liliaceae (18), Xanthorrhoeaceae (10), Colchicaceae (9), Araceae (4), Butomaceae (1) ve Ixioliriaceae (1)’dir. En fazla takson içeren cinsler; Allium L. (39), Muscari Mill. (14), Ornithogalum L. (11), Orchis L., Gagea Salisb., Iris L., Crocus L. ve Colchicum L. (9), Asphodeline Reichb. ve Fritillaria L. (8)’dır. Taksonların gövde tipleri; soğan (% 61.17), yumru (% 14.11), rizom (% 13.52) ve korm (% 11.17) olarak tespit edilmiştir. Endemik taksonların IUCN tehlike kategorilerine göre dağılımı; CR (2), EN (3), VU) (4), NT (6), LC (22) ve NE (3) şeklindedir. Çalışma sonucunda elde edilen veriler biyolojik çeşitliliğin korunması, devamlılığı ve yapılacak envanter çalışmalarına katkı sağlayacaktır.
Doğal Taş İşleme Tesislerinde Gürültü Kaynaklarının Araştırılması
Authors: Ertik Ömer Faruk , Erol İlknur
Published: February 2025

Bu çalışmada, 8 farklı mermer fabrikasında yer alan makinelerin eşdeğer gürültü seviyeleri belirlenmiştir. Gürültü ölçüm sonuçlarına göre gürültü seviyesi en yüksek olan makinelerin A fabrikasında kafa kesme, B fabrikasında trimming; C, E, F ve H fabrikasında S/T; D ve G fabrikasında köprü kesme makinelerinin olduğu tespit edilmiştir. Mermer fabrikalarında birden fazla makine bir arada çalıştığından dolayı fabrikaların bileşke gürültü değerleri hesaplanmıştır. En yüksek bileşke gürültü değeri A fabrikasında 109,3 dBA olarak tespit edilmiştir. Ayrıca fabrikalarda çalışanların 8 saatlik bir iş günü için maruz kaldıkları gürültü seviyeleri (LEX,8h) hesaplanmış ve gürültü yönetmeliğine göre değerlendirilmiştir. Tüm fabrikalarda çalışanların maruz kaldıkları gürültü değerlerinin sınır değeri (LEX,8h=87 dBA) aştığı tespit edilmiştir. Fabrikalar arasında benzer görev yapan makinelerin ortalama eşdeğer gürültü seviyeleri ile kestikleri doğal taşların shore sertlik değerleri ilişkilendirilmiştir. Çoklu ebatlama makinelerinde R2=%99’luk, trimming makinelerinde R2=%99’luk, kafa kesme makinelerinde R2=%98’lik, plaka silim makinelerinde R2=%95’lik, katrak makinelerinde R2=%77’lik, S/T makinelerinde ise R2=%73’lük bir ilişki tespit edilmiştir. Çalışanların gürültünün zararlı etkilerinden korunmaları için çeşitli önerilerde bulunulmuştur.
Farmasötik Formülasyonlarda ve Saf Formda Ketiapin Miktar Tayini İçin Operatör ve Çevre Dostu Analitik Tekniklerin Geliştirilmesi ve Validasyonu
Authors: Demir İbrahim , Bulduk İbrahim , Enginar Hüseyin , Çifci Cemal
Published: February 2025

Ketiapin, şizofreni, majör depresif bozukluk ve bipolar bozukluk tedavisinde kullanılan bir tür atipik antipsikotik ajandır. Bu çalışmada, ketiapinin saf ve formülasyonlarda miktar tayini için çevresel ve operatör dostu analitik yöntemler geliştirilmiştir. En iyi spektrumlar ultra saf su ile elde edildiği için, bu çözücü spektrofotometrik analiz için kullanıldı. Ketiapin standart çözeltilerinin 290 nm dalga boyunda UV ışığını maksimum düzeyde absorbe ettiği tespit edilmiş ve tespit için 290 nm dalga boyu seçilmiştir. Her iki yöntem de ICH kurallarına göre doğrulandı. Geliştirilen yöntemlerle 5-30 µg mL-1 konsantrasyon aralığında korelasyon katsayılarının 0,999'dan büyük olduğu tespit edildi. Geliştirilen yöntemler ticari formülasyonlara uygulanmıştır. Elde edilen sonuçlar ortalamalar için Student (t) testi ve standart sapmalar için Fischer (F) testi kullanılarak karşılaştırılmıştır. Yöntemler arasında önemli bir fark gözlenmemiştir. Geliştirilen yöntemlerin yeşillik değerlendirmesi AGREE yazılımı kullanılarak gerçekleştirilmiştir. Geliştirilen analitik yöntemler, ticari formülasyonlarda ketiapin miktar tayini için mükemmel çevresel ve analist dostu alternatifler olarak önerilmektedir.
The Effects of Heat-Moisture Modified Tapioca Starch On Dough Rheology and Bread Quality
Authors: Çetin Babaoğlu Hümeyra
Published: February 2025

In this study, the effects of substituting wheat flour with 5% and 10% tapioca starch (TS) or heat-moisture modified tapioca starch (MTS) on dough rheology and bread quality were investigated. The addition of MTS increased the water absorption of wheat flour (p
Uzun Dönem Yaşlandırmanın S2 Cam/Epoksi Kompozitlerin Mekanik Özelliklerine Etkisi
Authors: Kırar Ersan , Demircan Gökhan , Kısa Murat , Özen Mustafa
Published: February 2025

Kompozit malzemeler özgül mukavemetlerinin yüksek olması nedeniyle sıklıkla tercih edilmektedir. S2 cam elyaf takviyeli kompozit malzemelerde özgül mukavemeti oldukça yüksek olan takviye malzemelerinden biridir. Ancak kompozit malzemelerin kullanıldıkları ortamlarda zaman içinde yaşlanma kaynaklı olarak dayanımlarında düşüşler gerçekleşmektedir. Yaşlanma kaynaklı kompozitlerin dayanım düşüşlerinin belirlenmesi emniyet açısından önem arz etmektedir. Literatürde de kompozit malzemeleri çeşitli yaşlanma işlemleri sonrası inceleyen çalışmalara rastlanmaktadır. Ancak S2 cam/epoksi kompozitlerin 36 ay yapay deniz suyunda yaşlandırılması sonrası inceleme yapan çalışmaya rastlanmamıştır. Bu çalışmada S2 cam/epoksi kompozit malzemenin 36 ay yapay deniz suyu ortamında yaşlandırılması sonrası hem deneysel (düzlem içi çekme, basma ve Iosipesqu kayma testleri) hem de sonlu elemanlar analiziyle inceleme yapılmıştır. 36 ay yaşlandırma işlemi sonucunda; maksimum gerilme değerleri açısından kayma testinde %17,77, basma testinde %19,19 ve çekme testinde ise %24,39 düşüş olduğu tespit edilmiştir. Ayrıca testlerin sonlu elemanlar analizi sonuçlarıyla deneysel sonuçlar arasında maksimum hata oranı %6,97 olarak tesit edilmiş ve oldukça iyi bir uyum elde edilmiştir.
Contents of Kuwaiti TV drama and its impact on viewers
Authors: Khaled Youssef Al-Shayji Jamal
Published: February 2025

عندما ظهر جهاز التليفزيون على الساحة للمرة الأولى في أربعينيات وخمسينيات القرن العشرين أحدث تغييراً كبيراً في العالم في مجالات مختلفة أهمها على الإطلاق المجال الصناعي، إذ ونظرا للاقبال الكبير من المشاهدين لمتابعة هذا الجهاز المدهش سعى رجال الصناعة على تطويره وتحسين أداؤه بشكل مستمر فظهر التلفاز الملون لأول مرة في الستينيات من القرن الماضي، ثم الكابل التليفزيوني في السبعينيات، أعقبه صناعة أجهزة الفيديو في الثمانينيات؛ ثم التليفزيون عالي الدقة في أواخر التسعينيات. وجاء القرن الحادي والعشرين لينبثق عن التليفزيون الأجهزة اللوحية وأجهزة الكمبيوتر بأنواعها المختلفة؛ ثم الهواتف المحمولة، وتبدأ حكاية ظهور التليفزيون إلى عام 1926م، وتحديدا في السابع والعشرين من يناير عندما اجتمع علماء وباحثون في قاعة بالمعهد الملكي بلندن أمام شاشة ينظرون إليها في شوق وقلق في انتظار شيء غامض ومثير، وسرعان ما ظهرت على سطحها بعض الومضات التي بدأت تتخذ معالمها وخطوطها لتتحول إلى خيالات متحركة لكنها لم تكن واضحة بالشكل الكافي؛ وفي تلك اللحظة قفز المجتمعون مهللين مهنئين بعضهم بعضاً؛ فقد كانوا شهوداً على لحظة تاريخية فاصلة في العمل الإعلامي والصحفي والفني إذ شاهدوا أول تجربـة ناجحة لأعظم اختراعات التاريخ التكنولوجية في مجالات الاتصالات والإعلام؛ ومنذ ذلك الوقت تعاظم دور تلك الشاشة التي أطلق عليها فيما بعد التليفزيون في حياة الجماهير، وأصبحت بحق معجزة القرن العشرين لاعتمادها على الصوت والصورة والحركة
Doctoral Students' Help Seeking Behaviors
Authors: Ford Deana
Published: February 2025

The qualitative data was collected from doctoral students on a weekly basis. Students were asked to complete a behavior log which consisted of 10 questions and inquired about their help-seeking and studying behaviors.
Gianpiero Andreatta, 2022 - Il bosco racconta ancora - Altre storie di uomini, alberi e animali.
Authors: Lisa Chiara
Published: February 2025

Gianpiero Andreatta, 2022 - Il bosco racconta ancora - Altre storie di uomini, alberi e animali. Ed. Nitida Immagine. 144 p. ISBN 978-88-87439-55-9. Prezzo di copertina € 15,00.
ANALISIS DOCKING MOLEKULER BESERTA PREDIKSI ADME SENYAWA DERIVAT FLAVONOID SEBAGAI INHIBITOR ENZIM 15-LIPOXYGENASE-2
Authors: Listyani Tiara Ajeng , Ramadhani Diza Aulia , Raharjo Danang
Published: February 2025

Derivat flavonoid merupakan metabolit sekunder dari polifenol dan banyak ditemukan pada tumbuhan serta makanan dengan berbagai aktivitas biologi seperti antivirus dan antiinflamasi. Analisis docking molekuler senyawa derivat flavonoid terhadap enzim 15-lipoxygenase-2 bertujuan untuk menyelidiki potensi senyawa derivat flavonoid sebagai penghambat enzim 15-lipoxygenase-2 menggunakan program AutoDock Vina berdasarkan energi bebas pengikatan (ΔG), nilai RMSD, interaksi residu asam amino, serta prediksi ADME yang memenuhi kriteria dari Aturan Lipinski. Hasil docking dari tujuh senyawa derivat flavonoid ditemukan lima senyawa yang berpotensi sebagai penghambat 15-lipoxygenase-2 berdasarkan energi bebas pengikatan (ΔG), nilai RMSD, dan asam amino yang berkontribusi terhadap interaksi dengan ikatan hidrogen asam amino Leu, Ile, Phe, Asn dimana interaksi tersebut mirip dengan interaksi senyawa XRP yang merupakan ligan asli protein target yaitu epicatechin, epicatechin 3 gallat, luteolin, luteolin 7 glukosidase, dan quercetin. Prediksi nilai ADME pada penelitian ini menggunakan program SwissADME di mana tujuh senyawa derivat flavonoid memiliki berat molekul, nilai donor maupun akseptor ikatan hidrogen, dan nilai log P yang memenuhi kriteria dari Aturan Lipinski.
EVALUASI PROCUREMENT OBAT DI INSTALASI FARMASI RUMAH SAKIT UMUM DAERAH BREBES TAHUN 2023
Authors: Fahamsya Arifina , Rizqiyana Fika , Imanniar Deswita Tasyamul
Published: February 2025

Kegiatan procurement di Rumah Sakit mempunyai peranan penting dalam efektivitas serta efisiens pada pengelolaan obat, dampak dari pengelolaan yang tidak tepat dapat menghambat dan mengalami kekosongan persediaan obat serta menurunkan kualitas mutu pada Instalasi Farmasi tersebut. Perencanaan di RS dilaksanakan untuk menghindari terjadinya kekosongan obat. Perencanaan kebutuhan diwujudkan oleh adanya aktivitas pengadaan di RS. Penelitian ini memiliki tujuan guna mengetahui gambaran proses pelaksanaan procurement obat di Instalasi Farmasi RSUD Brebes periode 2023. Teknik total sampling digunakan dalam penelitian ini dengan sebanyak 6 panelis. Data penelitian ini diambil dengan mengisi kuesioner serta dilakukannya wawancara secara mendalam. Penilaian kuesioner menggunakan skala guttman dan dilakukan analisis data menggunakan aplikasi SPSS versi 22 serta analisis univariat guna menghitung data frekuensi dari masing-masing variabel. Hasil evaluasi dari penelitian ini menunjukkan bahwa proses perencanaan kebutuhan obat masuk kedalam kategori sangat baik dengan perolehan nilai (88%), dan pada proses pengadaan obat masuk kedalam kategori sangat baik dengan perolehan nilai (93%).
ANALISIS RISIKO MUSCULOSKLETAL DISORDERS (MSDS) PADA PEKERJA USAHA MIKRO PEMBUATAN ALAT MUSIK TRADISIONAL MENGGUNAKAN NORDIC BODY MAP
Authors: Pramono Tangguh Dwi , Subekti Agung Tyas , Atmoko Dwi
Published: February 2025

Usaha mikro mempunyai peranan dalam mengembangkan daerah pedesaan dan memaksimalkan alokasi sumber daya dengan mengolah bagian mentah menjadi produk.Keberadaan Usaha Mikro tidak luput dari berbagai permasalahan, mereka susah berkembang, pasarnya terbatas, dalam pengelolaannya juga ada keterbatasan terkait kemampuan SDM dalam mengelola usaha, dan juga ada keterbatasan terkait financial. Dari segala keterbatasan yang dihadapi pelaku Usaha Mikro, permaslahan yang berkaitan dengan aspek keselamatan dan kesehatan kerja pun banyak yang UMK abaikan. Pada kelompok usaha mikro pembuatan alat music rebana Desa Kaliwadas, banyak pekerja yang mengalami kelihan Kesehatan, seperti nyeri tulang punggung, leher dan lengan. Dari hasil observasi lapangan, banyak pekerja tidak dalam popsisi yang ergonomis dalam melakukan aktifitas kerja. Penyakit akibat kerja yang terjadi pada pekerja sektor UMKM dapat berpengaruh pada produktivitas kerja. Postur tubuh janggal merupakan penyebab utama penyakti akibat kerja yang berkaitan dengan faktor ergonomi, biasa disebut dengan Musculsokeletal Disorders (MSDs). MSDs merupakan salah satu penyakit akibat kerja yang mengalami gangguan kronik pada otot, tendon, dan saraf yang disebabkan oleh postur janggal, durasi kerja, frekuensi gerakan berulang. Tingkat keparahan penyakit kerja MSDs dapat diukur dengan tools Nordic Body Map (NBM). NBM merupakan alat yang sudah banyak digunakan untuk mengukur keluhan sakit pada masing-masing segmen tubuh manusia.
PENGARUH ARM SWING EXERCISE TERHADAP KADAR GLUKOSA DARAH PUASA PENDERITA DIABETES
Authors: Khasanah Dwi Uswatun , Ulfah Maria , Hidayati Sri
Published: February 2025

Angka kejadian diabetes terus meningkat dari tahun ke tahun. Salah satu penyebabnya gaya hidup sedenter akibat modernisasi. Kontrol glikemik yang buruk dalam jangka waktu yang lama dapat menimbulkan komplikasi. Latihan fisik secara teratur bermanfaat bagi penderita Diabetes untuk mengendalikan kadar glukosa darah. Namun hanya sedikit penderita Diabetes yang melakukan latihan fisik secara teratur. Diperlukan latihan fisik yang mampu mendorong penderita Diabetes untuk melakukan latihan fisik secara teratur seperti Arm Swing Exercise yang gerakannya sederhana, mudah dilakukan, nyaman, dan dapat dilakukan kapan saja. Penelitian ini bertujuan mengetahui pengaruh Arm Swing Exercise terhadap kadar glukosa darah penderita Diabetes. Penelitian ini menggunakan desain quasi-experimental dengan pendekatan nonequivalent control- group design. Populasi dalam penelitian ini adalah pasien diabetes di Puskesmas Bandung Kota Tegal yang memenuhi kriteria inklusi dan ekslusi. Besar sampel dalam penelitian ini adalah 36 orang, terdiri atas 18 orang untuk kelompok intervensi dan 18 orang untuk kelompok kontrol. Pengumpulan data melalui wawancara menggunakan kuesioner, pengukuran BB, TB, tekanan darah dan pemeriksaan kadar glukosa darah puasa. Analisa data menggunakan uji independen t-test. Hasil penelitian menunjukkan tidak adanya perbedaan yang bermakna kadar glukosa darah puasa setelah diberikan intervensi pada kedua kelompok (p value = 0,756).
GAMBARAN REGULASI EMOSI ORANGTUA DENGAN ANAK BERKEBUTUHAN KHUSUS
Authors: Insani Uswatun , Itsna Ita Nur
Published: February 2025

Orang tua  memiliki  peranan  yang  sangat  penting  dalam  mengasuh,  mendidik,  dan  merawat anak. Hal ini tidaklah mudah, apalagi ditambah kondisi anak yang memiliki kebutuhan khusus. Diperlukan penerimaan dan kesabaran dalam kesehariannya menghadapi keunikan yang dimiliki anaknya. Regulasi emosi orang tua yang memiliki anak berkebutuhan khusus merupakan kemampuan individu dalam mengelola emosi dan ditunjukkan dalam tingkah lakunya dalam merawat anak berkebutuhan khusus. Penelitian ini menggunakan instrument tentang regulasi emosi yang sudah baku dan didapatkan kategorisasi hasil pengukuran emotional regulation dibagi menjadi 2 yaitu cognitive reappraisal (mengendalikan emosi dengan mengubah cara pikir) dan expressive supression (menyimpan perasaan). Penelitian ini bertujuan untuk mengetahui gambaran regulasi emosi pada orang tua yang memiliki anak berkebutuhan khusus. Penelitian ini diharapkan bermanfaat  sebagai  referensi  bagi orang tua yang memiliki anak berkebutuhan khusus dalam memahami dan menerapkan  regulasi  emosi selama dalam pengasuhan.
GAMBARAN POLA ASUH ORANG TUA YANG MEMILIKI ANAK BERKEBUTUHAN KHUSUS (ABK) DI SLB NEGERI SLAWI
Authors: Faisaluddin Faisaluddin , Oktiawati Anisa , Unayah Maelia
Published: February 2025

Pola asuh orang tua sangat di butuhkan dalam perkembangan anak terutama pada anak berkebutuhan khusus, permasalahan yang di hadapi pada orang tua dengan anak berkebutuhan khusus sangatlah kompleks sehingga menjadikan pola asuh orang tua yang tidak konsisten akan mempengaruhi perkembangan emosional dan sosial anak. Pola asuh yang efektif dapat meningkatkan kualitas hidup anak, sehingga anak mampu menjalankan tantangan dalam menghadapi kegiatan sehari-hari nya. Tujuan penelitian ini adalah untuk mengetahui gambaran pola asuh orang tua yang memiliki anak berkebutuhan khusus di Sekolah Luar Biasa (SLB) Negeri Slawi. Metode penelitian ini menggunakan metode deskriptif yaitu melihat gambaran pola asuh yang diterapkan oleh orang tua yang memiliki ABK di SLB Negeri Slawi dan bertujuan untuk mendeskripsikan (memaparkan) peristiwa-peristiwa penting yang terjadi pada masa kini. Hasil dari penelitian ini adalah 79% orang tua menerapkan pola asuh demokratis, 21% dari orang tua menerapkan pola asuh persuasive, dan tidak ada orang tua yang menggunakan pola asuh authoritarian.