bluuebunny/crossref_metadata_2025 huggingface dataset:
Cancer Stem Cell-Like Circulating Tumor Cells Are Prognostic in Non-Small Cell Lung Cancer
Authors: Obermayr Eva , Koppensteiner Nina , Heinzl Nicole , Schuster Eva , Holzer Barbara , Fabikan Hannah , Weinlinger Christoph , Illini Oliver , Hochmair Maximilian , Zeillinger Robert
Published: November 2021

Despite recent advances in the treatment of non-small cell lung cancer (NSCLC), less than 10% of patients survive the first five years when the disease has already spread at primary diagnosis. Methods: Blood samples were taken from 118 NSCLC patients at primary diagnosis or at progression of the disease before the start of a new treatment line and enriched for circulating tumor cells (CTCs) by microfluidic Parsortix™ (Angle plc, Guildford GU2 7AF, UK) technology. The gene expression of epithelial cancer stem cell (CSC), epithelial to mesenchymal (EMT), and lung-related markers was assessed by qPCR, and the association of each marker with overall survival (OS) was evaluated using log-rank tests. Results: EpCAM was the most prevalent transcript, with 53.7% positive samples at primary diagnosis and 25.6% at recurrence. EpCAM and CK19, as well as NANOG, PROM1, TERT, CDH5, FAM83A, and PTHLH transcripts, were associated with worse OS. However, only the CSC-specific NANOG and PROM1 were related to the outcome both at primary diagnosis (NANOG: HR 3.21, 95%CI 1.02–10.14, p = 0.016; PROM1: HR 4.23, 95% CI 0.65–27.56, p = 0.007) and disease progression (NANOG: HR 4.17, 95%CI 0.72–24.14, p = 0.025; PROM1: HR 4.77, 95% CI 0.29–78.94, p = 0.032). Conclusions: The present study further underlines the relevance of the molecular characterization of CTCs. Our multi-marker analysis highlighted the prognostic value of cancer stem cell-related transcripts at primary diagnosis and disease progression.
Upgrading a Legacy Manufacturing Cell to IoT
Authors: Cunha João , Batista Nelson , Cardeira Carlos , Melicio Rui
Published: November 2021

Many industries, such as aeronautics construction are still equipped with legacy machines and are not keen to change old, however fully functional, equipment to new ones. Hence, an upgrade must be found to cope the legacy and fully functional machines to IoT technologies. This paper is a contribution to embrace those challenges in a new IoT architecture able to support the creation of solutions for Smart Industries. Internet of Things is increasing acceptance and the infrastructure for them is becoming available. This leads to an insurgence on investments and development of new dedicated IoT infrastructures. Industries need to adapt quickly to this constant technological evolution, implementing measures and connecting machines and robots at critical points to the Internet, instrumenting them using the concept of IoT, with the major goal of implementing a flexible, secure, easy to maintain and capable to evolve infrastructure, when legacy equipment is involved. The availability of machines and other critical assets directly affects the effectiveness of manufacturing operations. The architecture design offers security, flexibility, simplicity of implementation and maintenance, and is resilient to failures or attacks and technologically independent. Field tests are reported to evaluate key aspects of the proposed architecture.
Impacts of Climate Change on Livestock Location in the US: A Statistical Analysis
Authors: Wang Minglu , McCarl Bruce A.
Published: November 2021

Livestock production is a valuable part of US agriculture as it contributes 50% of total agricultural value. Climate change is likely a threat to livestock production, but research regarding the impact of climate change on livestock sectors is limited. This paper examines how climate change affects livestock mix and location. Specifically, we examine climate effects on grazing animals and, in particular, on beef cattle, dairy cattle, goats, and sheep. We examine this in the US based on county-level data by using fractional multinomial logit econometrics. Our results show that climate is an influential determinant of where livestock herds are located and species mix. The impacts of climate vary by species and region. We also find significant influences from geographic characteristics and animal product prices. Subsequently, we project how climate change would influence future livestock mix and location. It reveals a likely growth in beef cow land shares across most of the US with the largest gains in the northwest. We also find substitutions between species as climate change progresses with dairy cows exhibiting the largest reduction.
A Toolkit for the Investigation of Greek EFL Teachers’ Assessment Literacy
Authors: Gkogkou Eirini , Kofou Ifigenia
Published: November 2021

The role of assessment in a learner-centred environment is considered to be significant for both learners and teachers. Most of the time, however, it is used in traditional ways and ignores learners’ individual needs. Based on the results of a survey conducted in 2019, in which a questionnaire was administered to a hundred and twenty EFL teachers, the present study aims to investigate Greek EFL teachers’ responses to communicative testing techniques and their awareness of assessment methods and principles. The aforementioned survey revealed that the majority of EFL teachers in the Greek educational context use traditional tests to assess their students and, although they are aware of alternative assessment methods and the benefits they offer, they fail to employ them. Thus, a 106-item tool was created in order to help teachers design, develop, and critically evaluate tests, as well as reflect on their assessment techniques to promote the use of alternative assessment and supplement the teachers’ theoretical knowledge and experience. Ninety-three EFL teachers evaluated themselves and rated their practices through the toolkit to find out the type of assessors that they are. The findings revealed that a lot of the participants are aware of the key principles of assessment and try to assess the four skills in a communicative and authentic way to a great extent, but most of them are mainstream assessors. The findings can be used to help design samples of authentic tasks for all skills and assessment-related teacher training material.
Physico-Chemical Properties of NaV3O8 Prepared by Solid-State Reaction
Authors: Shchelkanova Mariya , Shekhtman Georgiy , Pershina Svetlana , Vovkotrub Emma
Published: November 2021

Sodium–vanadium oxide NaV3O8 is synthesized via solid-state method and optimum synthesis conditions are chosen based on the data of DSC and TG analysis. The material synthesized is characterized by X-ray phase analysis, Raman spectroscopy and scanning electron microscopy. The ratio V4+/V5+ in the sample obtained is determined by X-ray photoelectron spectroscopy. Conductivity of the material synthesized was measured by impedance spectroscopy, pulse potentiometry and DC method over the range RT–570 °C. It is shown that NaV3O8 has rather high conductivity essentially electron in type (6.3 × 10−2 at room temperature). AC and DC conductivity measurements are performed and cycling of symmetricNaV3O8|Na3.85Zr1.85Nb0.15Si3O12|NaV3O8 cell in galvanostatic conditions. Thermal stability is studied across 25–570 °C temperature range. The results obtained are compared with the properties of NaV3O8 produced via aqueous solution.
Analysis of Failure Mechanism in Joints with Positive Eccentricity in CFS Truss
Authors: Gordziej-Zagórowska Małgorzata , Urbańska-Galewska Elżbieta , Deniziak Patryk
Published: November 2021

The paper presents studies concerning the load-bearing capacity of truss joints with a positive eccentricity resulting from the arrangement of geometric members and the failure mechanisms observed in the joints. Based on the previously conducted experimental study, a numerical model of the tested fragment of the CFS truss with eccentricity in the joint was created and validated. All structural details of the tested truss and the loading method consistent with the experiment were taken into account. The results obtained from a uniaxial tensile tests on a steel samples and results estimated during destructive tests carried out on a full-scale of research model were taken into account in validation of the numerical model. Next, appropriate numerical analyses were carried out and parameters such as the eccentricity size in the joint and the wall thickness of sections (t = 1.0, 1.5 and 4.0 mm) were modified. In the range of the studied wall slenderness from λ > 70 (1.0 mm and 1.5 mm thick), it was confirmed that the resistance of truss joints made from CFS open cross-sections with a positive eccentricity, is greater than the resistance that results from known methods of steel structure dimensioning.
A Method of the Riemann–Hilbert Problem for Zhang’s Conjecture 2 in a Ferromagnetic 3D Ising Model: Topological Phases
Authors: Zhang Zhidong , Suzuki Osamu
Published: November 2021

A method of the Riemann–Hilbert problem is employed for Zhang’s conjecture 2 proposed in Philo. Mag. 87 (2007) 5309 for a ferromagnetic three-dimensional (3D) Ising model in a zero external magnetic field. In this work, we first prove that the 3D Ising model in the zero external magnetic field can be mapped to either a (3 + 1)-dimensional ((3 + 1)D) Ising spin lattice or a trivialized topological structure in the (3 + 1)D or four-dimensional (4D) space (Theorem 1). Following the procedures of realizing the representation of knots on the Riemann surface and formulating the Riemann–Hilbert problem in our preceding paper [O. Suzuki and Z.D. Zhang, Mathematics 9 (2021) 776], we introduce vertex operators of knot types and a flat vector bundle for the ferromagnetic 3D Ising model (Theorems 2 and 3). By applying the monoidal transforms to trivialize the knots/links in a 4D Riemann manifold and obtain new trivial knots, we proceed to renormalize the ferromagnetic 3D Ising model in the zero external magnetic field by use of the derivation of Gauss–Bonnet–Chern formula (Theorem 4). The ferromagnetic 3D Ising model with nontrivial topological structures can be realized as a trivial model on a nontrivial topological manifold. The topological phases generalized on wavevectors are determined by the Gauss–Bonnet–Chern formula, in consideration of the mathematical structure of the 3D Ising model. Hence we prove the Zhang’s conjecture 2 (main theorem). Finally, we utilize the ferromagnetic 3D Ising model as a platform for describing a sensible interplay between the physical properties of many-body interacting systems, algebra, topology, and geometry.
Learning Sets Theory Using Shadow Puppet: A Study of Javanese Ethnomathematics
Authors: Prahmana Rully Charitas Indra , Istiandaru Afit
Published: November 2021

Some countries have puppet culture in various forms, terms, and ways, including Indonesia. As a country with a diverse culture, it has detailed and comprehensive characteristics and stories related to puppets, especially the Javanese shadow puppet. Some experts have explored its characteristics and found out that it contains many mathematical elements which could be used as a starting point to learn mathematics. The elements, however, still focus on the exploration of geometry material. We hardly find any other material that has been explored as deep as the geometry material in the context of the Javanese shadow puppet. Therefore, this study aims to explore the other elements of mathematics potentially found in this context which—for this example—is the sets material. Besides, this study also discusses the righteous life values that the students could internalize during mathematics learning through shadow puppet culture. We used ethnography to explore it through literature study, documentation, and field notes. We found some interesting elements, characteristics, and patterns in the Javanese shadow puppet, which can be used as a starting point to learn the sets concept. Furthermore, the values and philosophy of the shadow puppet culture harbor the potential to foster the students’ good character and behavior.
Complex Regional Pain Syndrome in Athletes: Scoping Review
Authors: Moretti Antimo , Palomba Angela , Paoletta Marco , Liguori Sara , Toro Giuseppe , Iolascon Giovanni
Published: November 2021

Background and Objectives: Complex regional pain syndrome (CRPS) is a chronic condition characterized by disproportionate regional pain, usually affecting distal limbs, that follows trauma or surgery. Athletes may develop CRPS because of exposure to traumatic or overuse injuries. The aim of the present study is to review the available literature about CRPS type 1 in athletes. Materials and Methods: We searched two online databases (PubMed and Web of Science), selecting papers aiming at investigating CRPS type 1 (algodystrophy) in athletes. The analysis of databases was made considering original articles published until 30 June 2021, written in English. Results: Fifteen papers (12 case reports, 3 case series) were selected for a total of 20 clinical cases (15 females, 5 males), aged between 10 and 46 years (mean age 18.4 ± 9.8 standard deviation years). Patients included practiced different types of sport (soccer, athletics, gymnastics, basketball). The most involved anatomical sites were lower limbs, and time to diagnosis ranged from 2 days to 4 years. The most used treatments were pharmacological and physical therapies, but sometimes invasive approaches, as regional nerve, or lumbar sympathetic blocks, were provided. The main assessed outcomes were return to activity and pain. Conclusions: Our review suggests a higher prevalence of CRPS type 1 in younger people and in lower limbs than in general population but confirms the higher prevalence in females. However, the number of studies addressing CRPS in athletes is limited, as well as the number of involved patients, considering that only few and heterogeneous case reports were published about this topic. Moreover, the high prevalence of old studies (only 5 available studies in the last 10 years) might have influenced the choice of both assessment tools and management strategies. Despite these limitations, athletes showing disproportionate pain after sport-related injury should be promptly evaluated and treated through a multidimensional approach to avoid long-term consequences of algodystrophy.
Characteristics of Patients with Obstructive Sleep Apnea at High Risk for Cardiovascular Disease
Authors: Bouloukaki Izolde , Fanaridis Michail , Stathakis Georgios , Ermidou Christina , Kallergis Eleftherios , Moniaki Violeta , Mauroudi Eleni , Schiza Sophia E.
Published: November 2021

Background and Objectives: To evaluate the influence of obstructive sleep apnea (OSA)-related symptoms on prevalent cardiovascular disease (CVD) in a large clinical population of patients. Materials and Methods: A total of 2127 patients (mean age 55 years, 24% women) underwent diagnostic polysomnography and were evaluated using the Epworth sleepiness scale (ESS), the Athens Insomnia Scale (AIS), and the Beck Depression Inventory (BDI). We investigated the predictive value of OSA-associated symptoms for prevalent cardiovascular disease, after adjustment for relevant confounding factors including age, obesity, and co-morbidities. Results: Patients with OSA and CVD were older and had a higher Body Mass Index (BMI); the percentage of obese patients was also higher (83% vs. 70%, p < 0001). They also had greater neck, waist, and hip circumferences and a higher waist-to-hip ratio. Excessive daytime sleepiness (ESS ≥ 10) [odds ratio (95% CI) 1.112 (0.708–1.748), p = 0.64], insomnia symptoms (AIS ≥ 6) [odds ratio (95% CI) 0.748 (0.473–1.184), p = 0.21], frequent awakenings [odds ratio (95% CI) 1.599 (1.019–2.508), p = 0.06], and nocturia [odds ratio (95% CI) 1.359 (0.919–2.009), p = 0.124] were not associated with CVD after adjustment for the previous confounders. On the other hand, depressive symptoms (BDI ≥ 10) independently predicted prevalent CVD [odds ratio (95% CI) 1.476 (1.154–1.887), p = 0.002]. Further analysis in subgroups stratified by age, BMI, and gender demonstrated that depressive symptoms predicted prevalent CVD but only in the subgroup of younger (age group < 60 years), obese (BMI group ≥ 30), and male (OR = 1.959, 95% CI = 1.209–3.175, p = 0.006) OSA patients. Conclusions: OSA patients with CVD were more likely to complain of less typical OSA symptoms and depressive symptoms compared to patients without CVD in this large clinical patient cohort, supportingthecomplexity and heterogeneityof OSA.
A Review of Natural Products for Prevention of Acute Kidney Injury
Authors: Kang Hyun Goo , Lee Hyun Ki , Cho Kyu Bong , Park Sang Il
Published: November 2021

Background and Objectives: acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products—measured by blood urea nitrogen (BUN) and serum creatinine levels—over the course of hours to weeks. AKI occurs in about 20% of all hospitalized patients and is more common in the elderly. Therefore, it is necessary to prevent the occurrence of AKI, and to detect and treat early, since it is known that a prolonged period of kidney injury increases cardiovascular complications and the risk of death. Despite advances in modern medicine, there are no consistent treatment strategies for preventing the progression to chronic kidney disease. Through many studies, the safety and efficacy of natural products have been proven, and based on this, the time and cost required for new drug development can be reduced. In addition, research results on natural products are highly anticipated in the prevention and treatment of various diseases. In relation to AKI, many papers have reported that many natural products can prevent and treat AKI. Conclusions: in this paper, the results of studies on natural products related to AKI were found and summarized, and the mechanism by which the efficacy of AKI was demonstrated was reviewed. Many natural products show that AKI can be prevented and treated, suggesting that these natural products can help to develop new drugs. In addition, we may be helpful to elucidate additional mechanisms and meta-analysis in future natural product studies.
Absence of Wharton’s Jelly at the Abdominal Site of the Umbilical Cord Insertion. Rare Case Report and Review of the Literature
Authors: Botezatu Radu , Raduteanu Sandra , Ciobanu Anca Marina , Gica Nicolae , Peltecu Gheorghe , Panaitescu Anca Maria
Published: November 2021

Wharton’s jelly is a specialized connective tissue surrounding and protecting umbilical cord vessels. In its absence, the vessels are exposed to the risk of compression or rupture. Because the condition is very rare and there are no available antepartum investigation methods for diagnosis, these cases are usually discovered after delivery, frequently after in utero fetal demise. We report the fortunate case of a 29-year-old nulliparous woman, with an uncomplicated pregnancy, admitted at 39 weeks in labor where a persistently abnormal cardiotocographic trace led to delivery by cesarean section of a healthy 3500 g newborn. After delivery, a Wharton’s jelly anomaly was identified at the abdominal umbilical insertion (umbilical cord vessels, approximately 1 cm in length, were completely uncovered by Wharton’s jelly), which required surgical thread elective ligation. In the presence of a persistently abnormal CTG trace, in a pregnancy with no clinical settings suggestive of either chronic or acute fetal hypoxemia, the absence of Wharton’s jelly should be taken into consideration in the differential diagnosis.
Effective Parameters on Fabrication and Modification of Braid Hollow Fiber Membranes: A Review
Authors: Nazif Azadeh , Karkhanechi Hamed , Saljoughi Ehsan , Mousavi Seyed Mahmoud , Matsuyama Hideto
Published: November 2021

Hollow fiber membranes (HFMs) possess desired properties such as high surface area, desirable filtration efficiency, high packing density relative to other configurations. Nevertheless, they are often possible to break or damage during the high-pressure cleaning and aeration process. Recently, using the braid reinforcing as support is recommended to improve the mechanical strength of HFMs. The braid hollow fiber membrane (BHFM) is capable apply under higher pressure conditions. This review investigates the fabrication parameters and the methods for the improvement of BHFM performance.
Dispatch Optimization Model for Haulage Equipment between Stopes Based on Mine Short-Term Resource Planning
Authors: Li Ning , Feng Shuzhao , Ye Haiwang , Wang Qizhou , Jia Mingtao , Wang Liguan , Zhao Shugang , Chen Dongfang
Published: November 2021

The working environment of underground mines is complicated, making it difficult to construct an underground mine production plan. In response to the requirements for the preparation of a short-term production plan for underground mines, an optimization model for short-term resource planning was constructed, with the goal of maximizing the total revenue during the planning period. The artificial bee colony optimization algorithm is used to solve the model using MATLAB. According to the basic requirements of underground mine ore haulage and ore hoisting, a haulage equipment inter-stopes dispatch plan model was constructed, with the primary goal of minimizing the haulage equipment wait time. A non-dominated sorting genetic algorithm is used to solve the optimization model. An underground mine is examined using the two models, and the optimization results are compared and verified with the scheme obtained by using traditional optimization algorithms. Results show that based on the improved optimization algorithm, the use of short-term production planning schemes to guide mine production operations can increase the haulage equipment utilization rate, thereby increasing mine production revenue.
Novel Lanthanide (III) Complexes Derived from an Imidazole–Biphenyl–Carboxylate Ligand: Synthesis, Structure and Luminescence Properties
Authors: Sardaru Monica-Cornelia , Marangoci Narcisa Laura , Shova Sergiu , Bejan Dana
Published: November 2021

A series of neutral mononuclear lanthanide complexes [Ln(HL)2(NO3)3] (Ln = La, Ce, Nd, Eu, Gd, Dy, Ho) with rigid bidentate ligand, HL (4′-(1H-imidazol-1-yl)biphenyl-4-carboxylic acid) were synthesized under solvothermal conditions. The coordination compounds have been characterized by infrared spectroscopy, thermogravimetry, powder X-ray diffraction and elemental analysis. According to X-ray diffraction, all the complexes are a series of isostructural compounds crystallized in the P2/n monoclinic space group. Additionally, solid-state luminescence measurements of all complexes show that [Eu(HL)2(NO3)3] complex displays the characteristic emission peaks of Eu(III) ion at 593, 597, 615, and 651 nm.
Self-Assembly of Au-Fe3O4 Hybrid Nanoparticles Using a Sol–Gel Pechini Method
Authors: Ovejero Jesus G. , Garcia Miguel A. , Herrasti Pilar
Published: November 2021

The Pechini method has been used as a synthetic route for obtaining self-assembling magnetic and plasmonic nanoparticles in hybrid silica nanostructures. This manuscript evaluates the influence of shaking conditions, reaction time, and pH on the size and morphology of the nanostructures produced. The characterization of the nanomaterials was carried out by transmission electron microscopy (TEM) to evaluate the coating and size of the nanomaterials, Fourier-transform infrared spectroscopy (FT-IR) transmission spectra to evaluate the presence of the different coatings, and thermogravimetric analysis (TGA) curves to determine the amount of coating. The results obtained show that the best conditions to obtain core–satellite nanostructures with homogeneous silica shells and controlled sizes (<200 nm) include the use of slightly alkaline media, the ultrasound activation of silica condensation, and reaction times of around 2 h. These findings represent an important framework to establish a new general approach for the click chemistry assembling of inorganic nanostructures.
The Renin-Angiotensin System: A Key Role in SARS-CoV-2-Induced COVID-19
Authors: El-Arif George , Farhat Antonella , Khazaal Shaymaa , Annweiler Cédric , Kovacic Hervé , Wu Yingliang , Cao Zhijian , Fajloun Ziad , Khattar Ziad Abi , Sabatier Jean Marc
Published: November 2021

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), was first identified in Eastern Asia (Wuhan, China) in December 2019. The virus then spread to Europe and across all continents where it has led to higher mortality and morbidity, and was declared as a pandemic by the World Health Organization (WHO) in March 2020. Recently, different vaccines have been produced and seem to be more or less effective in protecting from COVID-19. The renin–angiotensin system (RAS), an essential enzymatic cascade involved in maintaining blood pressure and electrolyte balance, is involved in the pathogenicity of COVID-19, since the angiotensin-converting enzyme II (ACE2) acts as the cellular receptor for SARS-CoV-2 in many human tissues and organs. In fact, the viral entrance promotes a downregulation of ACE2 followed by RAS balance dysregulation and an overactivation of the angiotensin II (Ang II)–angiotensin II type I receptor (AT1R) axis, which is characterized by a strong vasoconstriction and the induction of the profibrotic, proapoptotic and proinflammatory signalizations in the lungs and other organs. This mechanism features a massive cytokine storm, hypercoagulation, an acute respiratory distress syndrome (ARDS) and subsequent multiple organ damage. While all individuals are vulnerable to SARS-CoV-2, the disease outcome and severity differ among people and countries and depend on a dual interaction between the virus and the affected host. Many studies have already pointed out the importance of host genetic polymorphisms (especially in the RAS) as well as other related factors such age, gender, lifestyle and habits and underlying pathologies or comorbidities (diabetes and cardiovascular diseases) that could render individuals at higher risk of infection and pathogenicity. In this review, we explore the correlation between all these risk factors as well as how and why they could account for severe post-COVID-19 complications.
Optimization of Medication Regimens in Patients with Type 2 Diabetes and Clinical Atherosclerotic Cardiovascular Disease
Authors: Prudencio Jarred , Cajudoy Paige , Waddell Donald
Published: November 2021

The American Diabetes Association recommends that patients with type II diabetes and atherosclerotic cardiovascular disease be prescribed an SGLT-2 inhibitor or GLP-1 agonist for cardioprotective benefit. This project assessed the use of these medications in this patient population in a rural clinic by measuring prescribing rates of SGLT-2/GLP-1 therapy before and after pharmacist interventions. Of the 60 patients identified at baseline, 39.39% (13/33) managed by a pharmacist were prescribed SGLT-2/GLP-1 therapy compared to the 14.81% (4/27) who had not seen a pharmacist (p = 0.025). Of the 43 patients that were not on SGLT-2/GLP-1 therapy at baseline, 13 were lost to follow-up and 13 had contraindications. For the 17 remaining patients, pharmacists recommended initiating SGLT-2/GLP-1 therapy and were able to successfully initiate therapy for 9 patients (52.94%). Pharmacist interventions improved the prescription rates from a baseline of 36.17% (17/47) to 55.3% (26/47) (p = 0.002), with SGLT-2/GLP-1 therapy contraindicated in 27.66% (13/47) of patients. This suggests that patients managed by a pharmacist have medication regimens that were optimized at a greater rate and pharmacists can have a positive impact on the appropriate medication usage in this population.
Prosthetic Rehabilitation of an Unusually Self-Obturated Cleft Palate Defect in an Adult Edentulous Patient Living in a Remote Rural Area. A Clinical Report
Authors: Artopoulou Ioli Ioanna , Salia Andromachi , Polyzois Gregory
Published: November 2021

Patients with unrepaired cleft palate defects still exist within remote rural areas. The prosthodontic rehabilitation of an adult edentulous cleft patient could be very demanding for treating maxillofacial prosthodontist, since most of them are edentulous, challenging the retention and the stability of the maxillary prosthesis. It is therefore highly important that cleft palate patients seek dental and prosthodontic care as early in their life as possible. In this report, an unusual case of a patient self-obturated cleft palate defect is presented. The patient’s self-made prosthesis was replaced by an appropriately fabricated pharyngeal obturator prosthesis in order to improve speech and swallowing.
Sign Stability of Dual Switching Linear Continuous-Time Positive Systems
Authors: Liu Liang , Long Fei , Mo Lipo , Mu Qianqian
Published: November 2021

This paper investigates 1-moment exponential stability and exponential mean-square stability (EMS stability) under average dwell time (ADT) and the preset deterministic switching mechanism of dual switching linear continuous-time positive systems when a numerical realization does not exist. The signs of subsystem matrices, but not their structures of magnitude, are key information that causes a qualitative concept of stability called sign stability. Both 1-moment exponential stability and EMS stability, which are the traditional stability concepts, are generalized intrinsically. Hence, both 1-moment exponential sign stability and EMS sign stability are introduced and are proven based on sign equivalency. It is shown that they are symmetrically and qualitatively stable. Notably, the notion of stability can be checked quantitatively using some examples.
f(T, B) Cosmography for High Redshifts
Authors: Escamilla-Rivera Celia , Rave-Franco Geovanny , Levi-Said Jackson
Published: November 2021

In light of the statistical performance of cosmological observations, in this work we present the cosmography in f(T,B) gravity. In this scenario we found a cosmological viable standard case that allows the reduction of the degeneracy between several f(T,B) models already proposed in the literature. Furthermore, we constrain this model using Pantheon SNeIa compilation, cosmic chronometers and a newly GRB calibrated data sample. We found that with an appropriate strategy for including the cosmographic parameter, we do produce a viable cosmology with our model within f(T,B) gravity.
Vaccine Knowledge, Awareness and Hesitancy: A Cross Sectional Survey among Parents Residing at Sandakan District, Sabah
Authors: Voo James Yau Hon , Lean Qi Ying , Ming Long Chiau , Md. Hanafiah Nur Hafzan , Al-Worafi Yaser Mohammed , Ibrahim Baharudin
Published: November 2021

Background: Incomplete childhood immunization against communicable diseases is a major concern and vaccine hesitancy remains a hurdle to overcome in primary vaccination programs. This study was to examine the parents’ vaccine knowledge, awareness and hesitancy in relation to their children’s immunization status. Methods: A cross-sectional questionnaire study design was used. The parents who brought their children for immunization visit or follow-up at four public health clinics located in Sandakan district were invited to participate in this survey. Informed consent was obtained before each participant completed a hard copy of self-administered questionnaire in either English or Malay versions. Results: Of 405 parents responded, they generally had good knowledge and awareness of vaccines, only a small percentage (6.8%) of parents were found vaccine hesitant. There were significant differences in vaccine knowledge and awareness in those from different education levels and employment status; similarly, these two factors also significantly affected the vaccine hesitancy among the parents. The parents’ knowledge score was found to be moderately associated with their awareness (r = 0.551, p < 0.01) and inversely correlated to vaccine hesitancy (r = −0.397, p < 0.01). Most of the children (n = 376, 92.8%) in the study were immunized. The children’s immunization status was significantly associated with the parents’ education level (p = 0.025). There was also a significant difference in the total vaccine knowledge scores between the groups of parents with different child immunization status (p = 0.05). Conclusion: This study revealed that parents with higher education had a better knowledge of vaccinations, were less vaccine hesitant and were more likely to ensure that their children complete the recommended course of immunization. It is crucial to ensure parents are well-informed about the safety and efficacy of vaccines so that the children are protected from communicable diseases by the child vaccination program.
Assessment of rational land use based on capitalization ratio: methodological approach
Authors: Svetlakov V.I.
Published: November 2021

The article provides a methodological approach to land value calculation and determination of the capitalization ratios. Based on the analysis of methods for land assessment, it is proposed to calculate the capitalization ratio by solving a system consisting of seven equations characterizing the state of the real estate market. The areas of possible use of the approach and the need to develop a resource model for the decomposition of real estate objects are substantiated in this paper.
Efficiency of GIS in the process of land registration
Authors: Khabarova I.A. , Khabarov D.A. , Kondratyev M.A.
Published: November 2021

The authors considered the sequence of actions for the implementation of state cadastral registration of land plots using geographic information systems, mentioned the improved mechanism for the use of GIS technologies for state cadastral registration, and assessed the effectiveness of such technologies. The authors noted that it is advisable to develop and adopt normative legal acts that regulate relations in the field of application of GIS systems in cadastral activities nowadays, and to bring all GIS to a solid maintenance and systematization, as well as to strengthen the involvement of users in the legal culture of open databases on the Internet using cartographic materials. By the authors, the developed proposals can be recommended for use by cadastral engineers to perform the procedures for state cadastral registration of land plots.
Disappearing nature. History, problems and prospects of representation of peasant labor in the paintings of Russian and soviet artists
Authors: Zanegina A.B. , Smolenskaya V.K. , Leventseva E.N. , Mironova E.I.
Published: November 2021

This article is an analysis of the reasons for the loss of interest of easel painters to the theme of rural labor and modern rural workers. The authors made proposals for solving this problem.
Development of rational land use in land policy of the Transnistrian Moldovan Republic
Authors: Shashkova A.V. , Solovtsov A.O.
Published: November 2021

The article considers the problem of the development of rational land use in land policy of the Transnistrian Moldovan Republic. In the times of socio-economic transformations, the issue of land and property relations is one of the most important. Land and property relations can’t be realized without participation of the state, this is manifested even in the states with a liberal economic model. The rational use of land resources is achieved by the state instruments as a combination of the necessary economic, environmental and social effects, as well as the coordination of public interests. The Pridnestrovian Moldavian Republic and its land policy are of great research interest, combining the accumulated experience of the Soviet period and building its own economic system.
Integration of arts synthesis into subject-spatial design of the Moscow metro
Authors: Balashov I.V. , Leventseva E.N. , Kraeva A.A. , Smolenskaya V.K.
Published: November 2021

The article analyzes the synthesis of monumental and decorative art in the design of metro stations, considers the issue of creating an underground space as a symbol of future happy life through the use of art elements, and raises the question of the future architectural design of the station interiors.
PERFIL DE CONSUMIDORES DE LOS NUEVOS SEGMENTOS DE MERCADO: CASO SALTILLO, COAHUILA
Authors: Méndez-Wong Adriana , Villarreal-Cavazos Juana Alicia , Aguilar-Garcés Elizabeth Ana
Published: November 2021

A través del tiempo, los mercadólogos han utilizado técnicas de segmentación especializadas para encontrar sus mercados meta. Angus y Westbrook,  (2018), (2019), (2020) y (2020) detallan dentro de las tendencias globales de consumo nuevos perfiles de clientes.

Con este trabajo se pretende abordar la propensión de prácticas de compra  de los  saltillense  a través de un estudio exploratorio / descriptivo, con enfoque cuantitativo  y  utilizando estadística descriptiva y análisis factorial. Aplicando  un instrumento de cuarenta y nueve ítems,  con una  escala de respuesta de tipo Likert del 1 al 7.  La muestra es de 275 sujetos de 15 a 78 años en la ciudad de Saltillo, Coahuila y el trabajo de campo se realizó durante los meses enero y  febrero del  año 2020.

El análisis realizado fue el de la varianza de un factor (ANOVA) con el fin de comprobar si hay diferencias significativas entre cada una de los ítems que integran la escala.

Los resultados del estudio nos permitieron comprender mejor a los consumidores que emergen en la actualidad en la ciudad de Saltillo, Coahuila.
APORTACIÓN DE LA MERCADOTECNIA AL ANÁLISIS DE LOS PROGRAMAS Y ACCIONES LOCALES PARA EL RESCATE Y PRESERVACIÓN DEL RÍO MAGDALENA DE LA CIUDAD DE MÉXICO
Authors: Mota-Nieto Jazmín , Velázquez-Pardo Silvia María del Carmen Celestina , Lerma-y-Kirchner Alejandro
Published: November 2021

La Mercadotecnia satisface necesidades y deseos humanos mediante bienes, servicios e ideas. La protección del ambiente y de ecosistemas es importante para garantizar el acceso a recursos básicos, salud, entornos favorables para actividades económicas y de esparcimiento y mejorar la calidad de vida de las personas.

Este trabajo analiza las acciones locales, gubernamentales y de la sociedad civil, de 2003 a 2020, para el rescate y preservación del río Magdalena, CDMX. Se analizaron cinco tipos de acciones: limpieza, saneamiento, manejo de recursos, mejoramiento urbano, difusión y cultura ambiental a partir de los enfoques de la mercadotecnia gubernamental, de causas sociales y sustentable. Este acercamiento ayudó a identificar necesidades, intereses y tendencias asociados al rescate del río por parte del gobierno y la sociedad civil.

Como resultado se determinó la necesidad de evaluaciones de impacto. Una de las metodologías propuestas es la Teoría del Cambio (TdC) que ayuda a detonar el diálogo entre actores, conocer sus opiniones, necesidades y promover la co-creación estratégica de rutas de impacto integrando las acciones de gobierno y sociedad.
Engineering Geological Investigation of the Kırık Tunnel Route
Authors: ÇÜMEN Özgür Fatih , KARAKAŞ Ahmet
Published: November 2021

Engineering structures are of great importance in the comfort and safe travel of people who prefer the highway in the existing transportation networks. Highway tunnels are one of the most important engineering structures that easily overcome transportation problems. This study investigates the geological and geotechnical structures of the Kırık tunnel on the Erzurum-Rize highway route, makes the rock mass classification required for tunnel excavation according to the New Austrian Tunneling Method and determines the tunnel support systems. Geological mapping, drillings, geological- geotechnical investigation based on in-situ and laboratory tests were carried out in order to reveal the physical and mechanical properties of the geological formations on the tunnel and to determine the basic data required by the project. It is divided into 4 classes on the basis of NATM Rock Classification along the tunnel axis. Rock support types related to rock classes defined as B1, B2, B3 and C2.
Pemanfaatan Teknologi Informasi Digital Sebagai Media Iinformasi Gereja Santo Petrus Warak
Authors: Marsella Elisabeth , Nastiti Putri , Puspitasari Fransiska Hernina
Published: November 2021

Gereja dapat diartikan dalam dua hal, yaitu sebagai tempat beribadah umat Kristen dan juga suatu badan yang mengelola kegiatan-kegiatan umat Kristen, baik yang bersifat liturgis atau non-liturgis. Demikian pula dengan Gereja Santo Petrus Warak yang selalu mengagendakan kegiatan-kegiatan tersebut. Sejauh ini, Gereja tidak banyak memberitakan kegiatan atau perkembangan yang ada di Gereja karena beberapa keterbatasan, seperti media dan sumber daya. Akibatnya, banyak umat tidak tahu perkembangan gereja. Media yang sering digunakan Gereja untuk mendistribusikan informasi kegiatan adalah pengumuman, teks misa, tabloid, buletin, dan majalah Gereja. Kelemahan media ini adalah informasi terpisah-pisah sehingga dokumentasi kegiatan Gereja tidak terpusat. Hal itu dikarenakan proses pemberitaan dilakukan oleh banyak orang dan data tidak terpusat di Gereja. Melihat permasalahan tersebut, dibuatlah website yang dapat digunakan untuk menyebarkan informasi kepada umat Gereja. Pengurus Gereja dapat menginformasikan profil Gereja, kegiatan-kegiatan apa saja yang akan dilakukan di Gereja, dan formulir-formulir yang diperlukan untuk administrasi Gereja. Selain itu, website ini memungkinkan umat untuk berpartisipasi mengirimkan berita tentang kegiatan liturgis atau non-liturgis di wilayah masing-masing. Pembuatan fitur website ini bertujuan untuk menjawab tantangan terbatasnya sumber daya manusia untuk mengunggah berita secara berkala.
SEO Untuk Meningkatkan Potensi Wisata Di Desa Ngargoretno
Authors: Yusnanto Tri , Arifah Fatimah Nur , Wahyudiono Sugeng
Published: November 2021

Borobudur merupakan barometer pariwisata Indonesia menjadi tolak ukur bagi pengembangan pariwisata destinasi lainnya. Pembangunan pariwisata borobudur dan sekitarnya yang telah dimulai sejak 20 tahun lalu mampu menjadikan sektor andalan kabupaten magelang selama bertahun-tahun. Industri pariwisata telah menciptakan multiplier effect bagi Provinsi Jawa Tengah khususnya Babupaten Magelang.Dengan begitu harus ada bebarapa cara marketing yang harus diterpakan agar orang dapat mengetahui tempat tersebut salah satunya dengan webite. Sekarang sebuah website telah diterapkan sebagai bahan dalam media promosi untuk memasarkan sebuah produk. Selain efektif, biayanya lebih murah serta mampu menjangkau ke seluruh dunia Akan tetapi belum semua website dapat memperoleh posisi teratas pada hasil pencarian atau SERP (Search Engine Result Page), bahkan sulit ditemukan oleh search engine karena sangat banyaknya website yang ada.Sehingga akan berdampak pada jumlah pengunjung website- nya. SEO adalah sebuah teknik pengoptimasian sebuah halaman yang mengandung kata kunci atau frase yang bersangkutan yang akan di index oleh mesin pencari sebagai kata kunci pecarian disini sagatlah diperlukan supaya website  menjadi optimal.
Workshop dan Pelatihan Social Commerce Untuk Siswa-Siswi Sekolah Menengah Atas Di Surabaya
Authors: Wirapraja Alexander , Hariyanti Novi Tri
Published: November 2021

Social commerce merupakan bentuk metode pemasaran moderen khususnya di Indonesia, lebih dari 60% masyarakat indonesia adalah pengguna media sosial. Peran informasi memegang peranan penting khususnya melalui konten-konten yang  disajikan di media sosial beserta dengan dampak sosial yang menyertainya .Pelatihan dan workshop ini memiliki tujuan untuk meningkatkan kesadaran para anak muda dalam memanfaatkan media sosial tidak hanya sebagai sarana aktualisasi diri namun juga sebagai sarana pemasaran untuk mengembangkan usaha kecil yang berdampak bagi mereka maupun lingkungan sekitar mereka sesuai dengan kemampuan dan minat yang mereka miliki. Peserta yang mengikuti pelatihan ini merupakan para tamu undangan dari tiga sekolah menengah atas di provinsi Jawa Timur. Pelatihan dan workshop ini dilakukan di aula lantai 1 Institut Informatika Indonesia dan rangkaian acara diawali dengan seminar mengenai peran media sosial dalam memanfaatkan jejaring komunitas untuk meningkatkan kualitas dari strategi pemasaran dan dilanjutkan dengan melakukan workshop pada laboratorium desain dan programming yang ada di Institut Informatika Indonesia. Hasil yang didapatkan adalah para siswa antusias dalam mengikuti acara ini terbukti dengan banyaknya pertanyaan yang diajukan dan mereka juga memahami dan mampu untuk menerapkan konsep pemasaran dengan menggunakan media sosial pada area lingkungan mereka masing-masing sesuai dengan bidang dan kompetensi yang dikuasai.
The Political Economy of Healthy and Sustainable Food Systems: An Introduction to a Special Issue
Authors: Baker Phillip , Lacy-Nichols Jennifer , Williams Owain , Labonté Ronald
Published: November 2021

Today’s food systems are contributing to multiple intersecting health and ecological crises. Many are now calling for transformative, or even radical, food systems change. Our starting assumption in this Special Issue is the broad claim that the transformative changes being called for in a global food system in crisis cannot – and ultimately will not – be achieved without intense scrutiny of and changes in the underlying political economies that drive today’s food systems. The aim is to draw from diverse disciplinary perspectives to critically evaluate the political economy of food systems, understand key challenges, and inform new thinking and action. We received 19 contributions covering a diversity of country contexts and perspectives, and revealing inter-connected challenges and opportunities for realising the transformation agenda. We find that a number of important changes in food governance and power relations have occurred in recent decades, with a displacement of power in four directions. First, upwards as globalization has given rise to more complex and globally integrated food systems governed increasingly by transnational food corporations (TFCs) and international financial actors. Second, downwards as urbanization and decentralization of authority in many countries gives cities and sub-national actors more prominence in food governance. Third, outwards with a greater role for corporate and civil society actors facilitated by an expansion of food industry power, and increasing preferences for market-orientated and multi-stakeholder forms of governance. Finally, power has also shifted inwards as markets have become increasingly concentrated through corporate strategies to gain market power within and across food supply chain segments. The transformation of food systems will ultimately require greater scrutiny of these challenges. Technical ‘problem-solving’ and overly-circumscribed policy approaches that depoliticise food systems challenges, are insufficient to generate the change we need, within the narrow time-frame we have. While there will be many paths to transformation, rights-based and commoning approaches hold great promise, based on principles of participation, accountability and non-discrimination, alongside coalition building and social mobilization, including social movements grounded in food sovereignty and agroecology.