bluuebunny/crossref_metadata_2025 huggingface dataset:
Chinese Investment in Malaysia: COVID-19, Democracy and Beyond
Authors: Chen Vivien , Chen Weitseng
Published: January 2023

China's rising influence in parts of the developing world has raised concerns among the US and its allies. In the wake of the COVID-19 outbreak, the provision of vaccines and aid to countries in the Global South have further heightened anxieties over the potential for diffusion of China's ideals. China's investments are thought to promote the diffusion of its perspectives of rule of law and democracy, posing a challenge to the global dominance of Western liberal democratic values. Nonetheless, few studies have examined how the diffusion of China's ideals may occur through its investments and infrastructure projects in young democracies such as Malaysia whose governance and legal system significantly outperform China's according to various global indexes. This article investigates the increasing engagement with China and the reasons for this trend against the backdrop of Malaysia's legal and political institutions inherited from the West. It considers how young democracies like Malaysia are vulnerable to China's influence, intentional or unintentional, through investment. The analysis sheds light on the mechanisms that give rise to such vulnerability, exploring how the electoral system and rule of law may facilitate and amplify the impact of Chinese investment, with broader implications. Shared tacit understandings, such as the instrumentality of law and the nexus between state and business, which facilitate cross-country cooperation are also examined.
The EU Vaccines Strategy: A Missed Opportunity for EU Public Health?
Authors: Della Corte Francesco Saverio
Published: January 2023

The response to the COVID-19 crisis implied an unprecedented involvement of the European Union (EU) executive in public health matters. In June 2020, the Member States agreed upon a joint EU Vaccines Strategy, whereby the European Commission was enabled to negotiate, support and allocate vaccine doses on their behalf. Entailing political and redistributive choices, the Commission’s centralised procurement presents some innovative patterns when compared to traditional EU executive action. This paper will focus on the institutionalisation of such patterns within the legal framework of the Health Emergency Preparedness and Response Authority (HERA). Did EU administrative law offer appropriate tools for this process? Or did the EU merely formalise the procedural and organisational schemes set up during the crisis? Answers to these questions will contribute to a fuller understanding of the administrative dimension of the new European Health Union and shed light on some recent evolutions of the EU administrative system.
Effects of haptic imagery on purchase intention
Authors: Inoue Yumi
Published: January 2023

The COVID‑19 pandemic has increased the popularity of online shopping, and companies are looking for ways to provide consumers with experiences that online shopping cannot provide, such as touching products and imagining them in use. In this context, the importance of haptic imagery of products showcased online is increasing. This study replicated and extended Peck et al.’s (2013, Journal of Consumer Psychology, 23, 189–196) finding that physical control and psychological ownership mediate the influence of haptic imagery on purchase intention. This study showed that imagining touching a product increased purchase intention through the mediation of physical control and psychological ownership compared with not imagining, conceptually replicating Peck et al.’s study. This study also examined the moderating effect of product involvement and showed that there was no moderator role of product involvement. The findings would have a practical application in marketing, such as encouraging consumers to imagine touching the product.
An electrohydrodynamic dance of unequal partners
Authors: Maass Corinna C.
Published: January 2023

The dynamics of charge-free dielectric droplets under electric fields in weakly conducting fluids is relevant to a large range of technological and environmental applications. In Sorgentone & Vlahovska (J. Fluid Mech., vol. 951, 2022, R2), the authors investigate by asymptotic theory and boundary integral simulations the motility states of a pair of dissimilar droplets at an arbitrary orientation to the electric field and find a state of steady motility that is carefully balanced between repulsion and contact.
“Goodbye Mshatta”: Connections and Disconnections on Berlin's Museum Island
Authors: Puzon Katarzyna
Published: January 2023

This essay is concerned with a contemporary art intervention in Berlin's Museum of Islamic Art, in the context of the Mshatta Façade's move. Sketching out Mshatta's relocation history, the essay highlights how the dynamic of connection and disconnection plays out in a museum setting and is embedded in epistemic concepts mobilized in knowledge-making about objects. Specifically, it focuses on an installation entitled “Goodbye Mschatta. Ich bin ein Fremder. Zweifach Fremder” (“Goodbye Mshatta. I Am a Stranger: Twofold a Stranger”), by a Syrian-born German visual artist who was commissioned to bid farewell to the Façade in its most recent location before it moves to the Pergamon Museum's north wing. Entering into a dialogue with Mshatta, his sculptural intervention pivoted around the themes of incompleteness, mélange, and in-betweenness. It revealed multiple connections and disconnections with regard to the Façade’s biography, while ostensibly disengaging from the debate on historical justice and imperial legacies.
Reference growth curves to identify weight status (underweight, overweight or obesity) in children and adolescents: systematic review
Authors: Alves Junior Carlos Alencar Souza , Martins Priscila Custódio , Moreno Aznar Luis Alberto , Silva Diego Augusto Santos
Published: January 2023

The identification of somatic growth, through reference curves, can be used to create strategies and public policies to reduce public health problems such as malnutrition and obesity and to identify underweight, overweight and obesity. The purpose of this systematic review was to identify studies providing reference growth curves for weight status in children and adolescents. A systematic search was conducted in eight databases and in gray literature (Google scholar). To assess the risk of bias/methodological quality of studies, the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-sectional Studies (NHLBI) was used. Overall, 86 studies that met the inclusion criteria were included. Through the values   of reference growth curves for the identification of underweight, overweight and obesity, it was possible to verify that there is great variability among percentiles for the identification of underweight, overweight and obesity. The most prevalent percentiles for underweight were P3 and P5; for overweight, the most prevalent was P85 and the most prevalent percentiles for obesity were P95 and P97. The most prevalent anthropometric indicators were Body Mass Index (BMI), Waist Circumference (WC), Body Mass (BM) for age and height for age. Conclusion: Such data can demonstrate that the optimal growth must be reached, through the standard growth curves, but that the reference curves demonstrate a cut of the population growth, raising possible variables that can influence the optimal growth, such as an increase in the practice of physical activities and an awareness of proper nutrition.
When Censorship Works: Exploring the Resilience of News Websites to Online Censorship
Authors: Lutscher Philipp M.
Published: January 2023

To what degree are news websites in autocracies resilient to online censorship? I explore this question in Egypt, which has begun to heavily censor news websites in recent years, alongside several other autocracies. Relying on a sample of 145 news outlets, I systematically explore how blocking affects traffic on outlets and their current statuses. Statistical tests show that blocked Egyptian outlets lost on average 54–55 per cent of their global traffic and are more likely to halt their activity. Heterogeneity analyses reveal that the loss in traffic was particularly strong for independent, Islamist opposition and larger outlets, and that permanently blocked websites were substantially more likely to halt services. These results support previous work on state repression and information control showing that censorship often works in reducing the consumption and provision of alternative political information.
Gender-Based Violence Research in Canadian Political Science: A Call to Action
Authors: Collier Cheryl N.
Published: January 2023

Gender-based violence is a prevalent and persistent societal problem in Canada that permeates all spaces, including politics. Yet sexual harassment, sexual assault and/or gender-based violence research is rarely found in mainstream political science in Canada or elsewhere. This article argues that this absence is highly problematic for a discipline that purports to centre itself on understanding power—who has it and who doesn't, and how to access it. It further argues for a normative intersectional and interdisciplinary approach, highlighting promising avenues of research in feminist institutionalism and Indigenous feminism to help achieve elusive solutions to gender-based violence in the future.
Cost-effectiveness of transdiagnostic group cognitive behavioural therapy for anxiety disorders v. treatment as usual: economic evaluation of a pragmatic randomized controlled trial over an 8-month time horizon using self-reported data
Authors: Chapdelaine Alexandra , Vasiliadis Helen-Maria , Provencher Martin D. , Norton Peter J. , Roberge Pasquale
Published: January 2023

Background

This economic evaluation supplements a pragmatic randomized controlled trial conducted in community care settings, which showed superior improvement in the symptoms of adults with anxiety disorders who received 12 sessions of transdiagnostic cognitive-behavioural group therapy in addition to treatment as usual (tCBT + TAU) compared to TAU alone.

Methods

This study evaluates the cost-utility and cost-effectiveness of tCBT + TAU over an 8-month time horizon. For the reference case, quality-adjusted life years (QALYs) obtained using the EQ-5D-5L, and the health system perspective were chosen. Alternatively, anxiety-free days (AFDs), derived from the Beck Anxiety Inventory, and the limited societal perspective were considered. Unadjusted incremental cost-effectiveness/utility ratios were calculated. Net-benefit regressions were done for a willingness-to-pay (WTP) thresholds range to build cost-effectiveness acceptability curves (CEAC). Sensitivity analyses were included.

Results

Compared to TAU (n = 114), tCBT + TAU (n = 117) generated additional QALYs, AFDs, and higher mental health care costs from the health system perspective. From the health system and the limited societal perspectives, at a WTP of Can$ 50 000/QALY, the CEACs showed that the probability of tCBT + TAU v. TAU being cost-effective was 97 and 89%. Promising cost-effectiveness results using AFDs are also presented. The participation of therapists from the public health sector could increase cost-effectiveness.

Conclusions

From the limited societal and health system perspectives, this first economic evaluation of tCBT shows favourable cost-effectiveness results at a WTP threshold of Can$ 50 000/QALY. Future research is needed to replicate findings in longer follow-up studies and different health system contexts to better inform decision-makers for a full-scale implementation.
Wisdom and methodological diversity in philosophy of religion
Authors: O'Grady Paul
Published: January 2023

There exists wide methodological diversity in philosophy of religion and many of the ways of responding to it are inadequate. This article argues that resources from virtue epistemology can help respond better, specifically connecting the issue to the notion of wisdom. A framework for this is articulated and then applied to Aquinas and Wittgenstein, chosen as utilizing starkly different methodologies in dealing with problems from philosophy of religion.
A philosophical perspective about the origin, evolution and distribution of life in the Universe
Authors: Nascimento-Dias Bruno Leonardo do
Published: January 2023

The main idea is to present the general aspects of the origin, evolution and distribution of life in the Universe from a Philosophy of Science perspective. The methodology used to develop this paper was through the intersection of favourable and unfavourable arguments from practitioners of science in the field of modern Astrobiology. The results were quite interesting and the historical crossover between the different arguments provides a great perspective on the research programme for the search for extraterrestrial life. Finally, although there is in fact no evidence that extraterrestrial life exists, the search for extraterrestrial life should not be considered as mere speculation. In the end, there are increasing indications that something extraordinary may be about to be found, whether on Mars, Europa, Enceladus or on some exoplanet.
The prevalence of common mental health problems and associated psychosocial issues in elite swimmers
Authors: Howarth Harrison , Evans Guy , Kruger Pieter , Dilkes Evie , Bell Gary , Kipps Courtney
Published: January 2023

Abstract: Introduction: The mental health of elite athletes has been recognised as of great importance. There have been relatively few studies examining the prevalence of mental health problems in swimmers. None have commented on the range of psychosocial problems associated with mental ill-health. The aim of this study was to identify the prevalence of common mental health problems and psychosocial problems in elite swimmers. Methods: The study was conducted on a national swimming squad competing at the international level. All athletes (n=55) were invited to participate. The response rate was 63.3% (n=36). The study was cross-sectional in design. Data was collected using a battery of psychometric tests yielding information on distress (The Distress Screener), anxiety and depression (PHQ-9, K10), sleep disturbance (PROMIS scale), alcohol consumption (AUDIT-C), smoking behaviour, adverse nutrition behaviour, career satisfaction (Career Satisfaction Scale) and mental toughness (Mental Toughness Index). Results: The prevalence of depression was 14% (n=5). Six percent (n=2) reported suicidal ideation in the last 2 weeks. Fourteen percent met criteria for distress. There were positive correlations between depression and sleep disturbance ( r=.343, p<.05), between anxiety/depression and distress ( r=.380, p<.05), and between depression and distress ( r=.531, p<.01). Career dissatisfaction was identified in 46% of participants and was inversely correlated with mental toughness ( r=.485, p<.01). Low mental toughness and adverse alcohol use were identified in 37% and 23% of participants, respectively. Conclusions: Elite swimmers experience common mental illnesses and associated psychosocial problems. There is a relationship between career dissatisfaction and low mental toughness. Sport governing bodies should assess their own athlete populations and implement programmes to support mental health.
Joint Analysis of Seismic and Electrical Observables Beneath the Central Appalachians Requires Partial Melt in the Upper Mantle
Authors: Mittal Ved , Long Maureen D. , Evans Rob L. , Byrnes Joseph S. , Bezada Maximiliano
Published: January 2023

The Central Appalachian Anomaly (CAA) is a region of the upper mantle beneath eastern North America that exhibits pronounced anomalies in its seismic velocity, seismic attenuation, and electrical conductivity structure. The CAA clearly expresses itself in low velocity, high attenuation, and high conductivity values; however, the present‐day composition and state of the asthenospheric upper mantle in the anomalous region remains imperfectly known. The collection of data from densely spaced, co‐located seismic and magnetotelluric arrays during the Mid‐Atlantic Geophysical Integrative Collaboration (MAGIC) experiment affords the opportunity to probe the structure and properties of the upper mantle in the CAA region in detail using multiple types of geophysical observations. Here, we present new observations of P and S wave travel times from teleseismic earthquakes measured at MAGIC stations, including a determination of how travel times deviate from the predictions of a standard 1‐D reference model. These observations constrain the ratio of the P to S wave travel time perturbations associated with the CAA, which in turn allows us to estimate the ratio of P and S wave velocity anomalies. We combine these observations with previously published estimates of seismic attenuation and electrical conductivity in the upper mantle beneath the MAGIC array, and carry out forward modeling to determine reasonable ranges of temperature, partial melt fraction, water content, and composition for the CAA. Our results suggest that 1%–2% partial melt is required to simultaneously explain the velocity, attenuation, and electrical conductivity observations beneath the MAGIC array.
The Stratosphere‐Ionosphere‐Protonosphere Coupling: Evidence From the Ion Composition Observations During the 2009 Sudden Stratospheric Warming
Authors: Zhang Ruilong , Liu Libo , Chen Yiding , Le Huijun , Li Wenbo
Published: January 2023

Previous studies suggested that sudden stratospheric warmings (SSW) change the global atmosphere from troposphere to thermosphere/ionosphere. We report the low‐latitude O+ and H+ composition at 840‐km altitude during the 2009 SSW, with the DMSP satellite morning measurements. Our results indicate that the stratospheric variation around 30‐km altitude modulates the ion exchange between the ionosphere and protonosphere via the vertical and field‐aligned plasma drifts due to the enhanced lunar semidiurnal tides. The upward disturbance drift uplifts the ionospheric O+ into the protonosphere, and most O+ is changed to H+ via chemical coupling, while the O+/H+ transition height does not change under combined effects of the southward and upward disturbance drifts on 24–29 January. The disturbance drift turns downward, lowers the O+/H+ transition height, depletes the O+ density in the protonosphere, and the H+ at higher altitudes moves downward to supply the H+ at 840 km from 30 January to 5 February.
Radiation-induced gastrointestinal (GI) syndrome as a function of age
Authors: Li Hongyan , Kucharavy Herman C. , Hajj Carla , Zhao Liyang , Hua Guoqiang , Glass Ryan , Paty Phillip B. , Fuks Zvi , Kolesnick Richard , Hubbard Karen , Haimovitz-Friedman Adriana
Published: January 2023

Previous studies show increased sensitivity of older mice (28–29 months) compared with young adult mice (3 months, possessing a mature immune system) to radiation-induced GI lethality. Age-dependent lethality was associated with higher levels of apoptotic stem cells in small intestinal crypts that correlated with sphingomyelinase activity, a source of pro-apoptotic ceramide. The objective of this study is to determine whether the cycling crypt base columnar cells (CBCs) in aging animals are specifically more sensitive to radiation effects than the CBCs in young adult mice, and to identify factors that contribute to increased radiosensitivity. Mortality induced by subtotal body radiation was assessed at different doses (13 Gy, 14 Gy, and 15 Gy) in young adult mice versus older mice. Each dose was evaluated for the occurrence of lethal GI syndrome. A higher death rate due to radiation-induced GI syndrome was observed in older mice as compared with young adult mice: 30 vs. 0% at 13 Gy, 90 vs. 40% at 14 Gy, and 100 vs. 60% at 15 Gy. Radiation-induced damage to crypts was determined by measuring crypt regeneration (H&E staining, Ki67 expression), CBC biomarkers (lgr5 and ascl2), premature senescence (SA-β-gal activity), and apoptosis of CBCs. At all three doses, crypt microcolony survival assays showed that the older mice had fewer regenerating crypts at 3.5 days post-radiation treatment. Furthermore, in the older animals, baseline CBCs numbers per circumference were significantly decreased, correlating with an elevated apoptotic index. Analysis of tissue damage showed an increased number of senescent CBCs per crypt circumference in older mice relative to younger mice, where the latter was not significantly affected by radiation treatment. It is concluded that enhanced sensitivity to radiation-induced GI syndrome and higher mortality in older mice can be attributed to a decreased capacity to regenerate crypts, presumably due to increased apoptosis and senescence of CBCs.
Visualization of translation and protein biogenesis at the ER membrane
Authors: Gemmer Max , Chaillet Marten L. , van Loenhout Joyce , Cuevas Arenas Rodrigo , Vismpas Dimitrios , Gröllers-Mulderij Mariska , Koh Fujiet A. , Albanese Pascal , Scheltema Richard A. , Howes Stuart C. , Kotecha Abhay , Fedry Juliette , Förster Friedrich
Published: January 2023

The dynamic ribosome–translocon complex, which resides at the endoplasmic reticulum (ER) membrane, produces a major fraction of the human proteome1,2. It governs the synthesis, translocation, membrane insertion, N-glycosylation, folding and disulfide-bond formation of nascent proteins. Although individual components of this machinery have been studied at high resolution in isolation3–7, insights into their interplay in the native membrane remain limited. Here we use cryo-electron tomography, extensive classification and molecular modelling to capture snapshots of mRNA translation and protein maturation at the ER membrane at molecular resolution. We identify a highly abundant classical pre-translocation intermediate with eukaryotic elongation factor 1a (eEF1a) in an extended conformation, suggesting that eEF1a may remain associated with the ribosome after GTP hydrolysis during proofreading. At the ER membrane, distinct polysomes bind to different ER translocons specialized in the synthesis of proteins with signal peptides or multipass transmembrane proteins with the translocon-associated protein complex (TRAP) present in both. The near-complete atomic model of the most abundant ER translocon variant comprising the protein-conducting channel SEC61, TRAP and the oligosaccharyltransferase complex A (OSTA) reveals specific interactions of TRAP with other translocon components. We observe stoichiometric and sub-stoichiometric cofactors associated with OSTA, which are likely to include protein isomerases. In sum, we visualize ER-bound polysomes with their coordinated downstream machinery.
Externally-triggerable optical pump-probe scanning tunneling microscopy with a time resolution of tens-picosecond
Authors: Iwaya Katsuya , Yokota Munenori , Hanada Hiroaki , Mogi Hiroyuki , Yoshida Shoji , Takeuchi Osamu , Miyatake Yutaka , Shigekawa Hidemi
Published: January 2023

Photoinduced carrier dynamics of nanostructures play a crucial role in developing novel functionalities in advanced materials. Optical pump-probe scanning tunneling microscopy (OPP-STM) represents distinctive capabilities of real-space imaging of such carrier dynamics with nanoscale spatial resolution. However, combining the advanced technology of ultrafast pulsed lasers with STM for stable time-resolved measurements has remained challenging. The recent OPP-STM system, whose laser-pulse timing is electrically controlled by external triggers, has significantly simplified this combination but limited its application due to nanosecond temporal resolution. Here we report an externally-triggerable OPP-STM system with a temporal resolution in the tens-picosecond range. We also realize the stable laser illumination of the tip-sample junction by placing a position-movable aspheric lens driven by piezo actuators directly on the STM stage and by employing an optical beam stabilization system. We demonstrate the OPP-STM measurements on GaAs(110) surfaces, observing carrier dynamics with a decay time of $$\sim 170$$

∼
170

 ps and revealing local carrier dynamics at features including a step edge and a nanoscale defect. The stable OPP-STM measurements with the tens-picosecond resolution by the electrical control of laser pulses highlight the potential capabilities of this system for investigating nanoscale carrier dynamics of a wide range of functional materials.
Proselfs depend more on model-based than model-free learning in a non-social probabilistic state-transition task
Authors: Oguchi Mineki , Li Yang , Matsumoto Yoshie , Kiyonari Toko , Yamamoto Kazuhiko , Sugiura Shigeki , Sakagami Masamichi
Published: January 2023

Humans form complex societies in which we routinely engage in social decision-making regarding the allocation of resources among ourselves and others. One dimension that characterizes social decision-making in particular is whether to prioritize self-interest or respect for others—proself or prosocial. What causes this individual difference in social value orientation? Recent developments in the social dual-process theory argue that social decision-making is characterized by its underlying domain-general learning systems: the model-free and model-based systems. In line with this “learning” approach, we propose and experimentally test the hypothesis that differences in social preferences stem from which learning system is dominant in an individual. Here, we used a non-social state transition task that allowed us to assess the balance between model-free/model-based learning and investigate its relation to the social value orientations. The results showed that proselfs depended more on model-based learning, whereas prosocials depended more on model-free learning. Reward amount and reaction time analyses showed that proselfs learned the task structure earlier in the session than prosocials, reflecting their difference in model-based/model-free learning dependence. These findings support the learning hypothesis on what makes differences in social preferences and have implications for understanding the mechanisms of prosocial behavior.
Dynamics of immune responses are inconsistent when trauma patients are grouped by injury severity score and clinical outcomes
Authors: Yang Ya-Wen , Wu Che-Hsiung , Tsai Huei-Ting , Chen Ying-Ru , Chang Yu-Ping , Han Yin-Yi , Wu Tiffany E. , Hu Ray-Heng
Published: January 2023

The injury severity score (ISS) is used in daily practice to evaluate the severity of trauma patients; however, the score is not always consistent with the prognosis. After injury, systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) are related to the prognosis of trauma patients. We aimed to evaluate the associations between the immune response and prognosis in trauma patients. Patients who admitted to the Trauma Intensive Care Unit (ICU) were eligible. Whole blood samples were collected at admission, and then 6, 12, 24, 48 and 72 h after admission. Natural killer (NK) cells, lymphocyte subset population and cytokines release were identified using flow cytometry. We grouped patients by their ISS (≤ 25 and > 25 as very severe injury) and ICU stay (≤ 10 days as a short ICU stay and > 10 days as a long ICU stay) for evaluation. Fifty-three patients were enrolled. ICU stay but not ISS was close correlated with activity daily living (ADL) at discharge. Patients with a long ICU stay had an immediate increase in NK cells followed by lymphopenia which persisted for 48 h. Immediate activation of CD8+ T cells and then exhaustion with a higher programmed cell death-1 (PD-1) expression and suppression of CD4+ T cells with a shift to an anti-inflammatory Th2 phenotype were also observed in the patients with a long ICU stay. When the patients were grouped by ISS, the dynamics of immune responses were inconsistent to those when the patients were grouped by ICU stay. Immune responses are associated with the prognosis of trauma patients, however the currently used clinical parameters may not accurately reflect immune responses. Further investigations are needed to identify accurate predictors of prognosis in trauma patients.
Effect of different end-capped donor moieties on non-fullerenes based non-covalently fused-ring derivatives for achieving high-performance NLO properties
Authors: Khalid Muhammad , Shafiq Iqra , Umm-e-Hani  , Mahmood Khalid , Hussain Riaz , ur Rehman Muhammad Fayyaz , Assiri Mohammed A. , Imran Muhammad , Akram Muhammad Safwan
Published: January 2023

A series of derivatives (DOCD2–DOCD6) with D–π–A configuration was designed by substituting various efficient donor moieties via the structural tailoring of o-DOC6-2F. Quantum-chemical approaches were used to analyze the optoelectronic properties of the designed chromophores. Particularly, M06/6-311G(d,p) functional was employed to investigate the non-linear optical (NLO) response (linear polarizability ⟨α⟩, first (βtot) and second ($$\upgamma$$
γ
tot) order hyperpolarizabilities) of the designed derivatives. A variety of analyses such as frontier molecular orbital (FMO), absorption spectra, transition density matrix (TDMs), density of states (DOS), natural bond orbital (NBO) and global reactivity parameters (GRPs) were employed to explore the optoelectronic response of aforementioned chromophores. FMO investigation revealed that DOCD2 showed the least energy gap (1.657 eV) among all the compounds with an excellent transference of charge towards the acceptor from the donor. Further, DOS pictographs and TDMs heat maps also supported FMO results, corroborating the presence of charge separation states along with efficient charge transitions. NBO analysis showed that π-linker and donors possessed positive charges while acceptors retained negative charges confirming the D–π–A architecture of the studied compounds. The λmax values of designed chromophores (659.070–717.875 nm) were found to have broader spectra. The GRPs were also examined utilizing energy band gaps of EHOMO and ELUMO for the entitled compounds. Among all the derivatives, DOCD2 showed the highest values of βtot (7.184 × 10–27 esu) and $$\upgamma$$
γ
tot (1.676 × 10–31 esu), in coherence with the reduced band gap (1.657 eV), indicating future potentiality for NLO materials.
Viable cryopreserved human bone graft exhibit superior osteogenic properties in mandibular lateral augmentation
Authors: Deluiz Daniel , Delcroix Gaëtan J.-R. , Fraga Samira R. G. , D’Ippolito Gianluca , Grau-Monge Cristina , Bonnin-Marquez Andrea , Reiner Teresita , Amadeu Thaís , Tinoco Eduardo M. B. , Schiller Paul Christian
Published: January 2023

Lack of bone volume to place dental implants is frequently a problem in the reconstruction of edentulous patients. Even though autografts are the gold standard for jaw regeneration, morbidity associated with the harvesting site stimulates the demand for other substitutes. The aim of this study is to characterize the incorporation and the osteogenic ability of a viable cryopreserved human bone graft (VC-HBG) in the mandibular augmentation in rats. Bone chips from fresh human vertebrae cadaveric donors were processed, cryoprotected and deep-frozen at − 80 °C maintaining its cell viability. A jaw augmentation model was used in 20 athymic nude rats allocated into 2 groups to either receive the VC-HBG or an acellular graft as control (A-HBG). The assessment of the grafts' incorporation was performed at 4 and 8 weeks by micro-CT, histomorphometry and immunohistochemistry. Bone volume gain was significantly higher for the VC-HBG group at both time points. At 4 weeks, the A-HBG group presented significantly higher mineral density, but at 8 weeks, the VC-HBG group showed significantly higher values than the A-HBG. There was no statistical difference between VC-HBG and A-HBG groups at 4-weeks for remaining graft particles, while at 8 weeks, the VC-HBG group showed significantly less graft remnants. Collagen I, osteopontin and tartrate-resistant acid phosphatase expression were significantly higher in the VC-HBG group at both time points, while osteocalcin expression was significantly higher in the VC-HBG group at 8-weeks compared to the A-HBG group. This experimental research demonstrated that the VC-HBG shows positive osteogenic properties, greater bone formation, higher rate of bone remodeling and a better overall incorporation in rats' mandibles compared to the A-HBG.
Data mining combines bioinformatics discover immunoinfiltration-related gene SERPINE1 as a biomarker for diagnosis and prognosis of stomach adenocarcinoma
Authors: Zhai Yiyan , Liu Xinkui , Huang Zhihong , Zhang Jingyuan , Stalin Antony , Tan Yingying , Zhang Fanqin , Chen Meilin , Shi Rui , Huang Jiaqi , Wu Chao , Wu Zhishan , Lu Shan , You Leiming , Wu Jiarui
Published: January 2023

Stomach adenocarcinoma (STAD) is a type of cancer which often at itsadvanced stage apon diagnosis and mortality in clinical practice. Several factors influencethe prognosis of STAD, including the expression and regulation of immune cells in the tumor microenvironment. We here investigated the biomarkers related to the diagnosis and prognosis of gastric cancer, hoping to provide insights for the diagnosis and treatment of gastric cancer in the future. STAD and normal patient RNA sequencing data sets were accessed from the cancer genome atlas (TCGA database). Differential genes were determined and obtained by using the R package DESeq2. The stromal, immune, and ESTIMATE scores are calculated by the ESTIMATE algorithm, followed by the modular genes screening using the R package WGCNA. Subsequently, the intersection between the modular gene and the differential gene was taken and the STRING database was used for PPI network module analysis. The R packages clusterProfiler, enrichplot, and ggplot2 were used for GO and KEGG enrichment analysis. Cox regression analysis was used to screen survival-related genes, and finally, the R package Venn Diagram was used to take the intersection and obtain 7 hub genes. The time-dependent ROC curve and Kaplan–Meier survival curve were used to find the SERPINE1 gene, which plays a critical role in prognosis. Finally, the expression pattern, clinical characteristics, and regulatory mechanism of SERPINE1 were analyzed in STAD. We revealed that the expression of SERPINE1 was significantly increased in the samples from STAD compared with normal samples. Cox regression, time-dependent ROC, and Kaplan–Meier survival analyses demonstrated that SERPINE1 was significantly related to the adverse prognosis of STAD patients. The expression of SERPINE1 increased with the progression of T, N, and M classification of the tumor. In addition, the results of immune infiltration analysis indicated that the immune cells’ expression were higher in high SERPINE1 expression group than that in low SERPINE1 expression group, including CD4+ T cells, B cells, CD8+ T cells, macrophages, neutrophils and other immune cells. SERPINE1 was closely related to immune cells in the STAD immune microenvironment and had a synergistic effect with the immune checkpoints PD1 and PD-L1. In conclusion, we proved that SERPINE1 is a promising prognostic and diagnostic biomarker for STAD and a potential target for immunotherapy.
Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection
Authors: Lv Haifeng , Jiang Yanming , Zhu Geli , Liu Shiyi , Wang Dian , Wang Jie , Zhao Ke , Liu Jing
Published: January 2023

This case–control study aimed to identify the clinical characteristics and explore the risk factors for liver fibrosis in metabolic associated fatty liver disease (MAFLD) patients with hepatitis B virus (HBV) infection. The patients were grouped into MAFLD + HBV and MAFLD (without HBV infection). Propensity score matching (PSM) was used to match baseline features between the groups. We included 401 patients with biopsy-proven MAFLD, 179 of whom had HBV infection. A total of 83 pairs were successfully matched via PSM, and steatosis scores and ballooning in the MAFLD + HBV group were lower than those in the MAFLD group, while the inflammation scores and liver fibrosis stages were higher. After adjusted for confounding factors, HBV infection was associated with a higher risk of significant liver fibrosis in patients with MAFLD [odds ratio (OR): 3.140, P = 0.003]. Overall, 43.58% (78/179) of patients in the MAFLD + HBV group had significant liver fibrosis. Further multivariate regression analysis, hypertension (OR: 2.640; P = 0.031), type 2 diabetes (OR: 4.939; P = 0.035), and elevated glutamyl-transferase levels (OR: 3.980; P = 0.001) were risk factors for liver fibrosis in the MAFLD + HBV group. This suggests metabolic rather than viral factors are more closely associated with liver fibrosis in MAFLD patients with HBV infection.
Iterated cross validation method for prediction of survival in diffuse large B-cell lymphoma for small size dataset
Authors: Chang Chin-Chuan , Chen Chien-Hua , Hsieh Jer-Guang , Jeng Jyh-Horng
Published: January 2023

Efforts have been made to improve the risk stratification model for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed to evaluate the disease prognosis using machine learning models with iterated cross validation (CV) method. A total of 122 patients with pathologically confirmed DLBCL and receiving rituximab-containing chemotherapy were enrolled. Contributions of clinical, laboratory, and metabolic imaging parameters from fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scans to the prognosis were evaluated using five regression models, namely logistic regression, random forest, support vector classifier (SVC), deep neural network (DNN), and fuzzy neural network models. Binary classification predictions for 3-year progression free survival (PFS) and 3-year overall survival (OS) were conducted. The 10-iterated fivefold CV with shuffling process was conducted to predict the capability of learning machines. The median PFS and OS were 41.0 and 43.6 months, respectively. Two indicators were found to be independent predictors for prognosis: international prognostic index and total metabolic tumor volume (MTVsum) from FDG PET/CT. For PFS, SVC and DNN (both with accuracy 71%) have the best predictive results, of which outperformed other algorithms. For OS, the DNN has the best predictive result (accuracy 76%). Using clinical and metabolic parameters as input variables, the machine learning methods with iterated CV method add the predictive values for PFS and OS evaluation in DLBCL patients.
Diversity enables the jump towards cooperation for the Traveler’s Dilemma
Authors: Ramírez María Alejandra , Smerlak Matteo , Traulsen Arne , Jost Jürgen
Published: January 2023

Social dilemmas are situations in which collective welfare is at odds with individual gain. One widely studied example, due to the conflict it poses between human behaviour and game theoretic reasoning, is the Traveler’s Dilemma. The dilemma relies on the players’ incentive to undercut their opponent at the expense of losing a collective high payoff. Such individual incentive leads players to a systematic mutual undercutting until the lowest possible payoff is reached, which is the game’s unique Nash equilibrium. However, if players were satisfied with a high payoff -that is not necessarily higher than their opponent’s- they would both be better off individually and collectively. Here, we explain how it is possible to converge to this cooperative high payoff equilibrium. Our analysis focuses on decomposing the dilemma into a local and a global game. We show that players need to escape the local maximisation and jump to the global game, in order to reach the cooperative equilibrium. Using a dynamic approach, based on evolutionary game theory and learning theory models, we find that diversity, understood as the presence of suboptimal strategies, is the general mechanism that enables the jump towards cooperation.
Containerized cloud-based honeypot deception for tracking attackers
Authors: Priya V. S. Devi , Chakkaravarthy S. Sibi
Published: January 2023

Discovering malicious packets amid a cloud of normal activity, whether you use an IDS or gather and analyze machine and device log files on company infrastructure, may be challenging and time consuming. The vulnerability landscape is rapidly evolving, and it will only become worse as more and more developing technologies, such as IoT, Industrial Automation, CPS, Digital Twins, etc are digitally connected. A honey trap aids in identifying malicious packets easily as, after a few rapid calibrations to eliminate false positives. Besides analyzing and reporting particular invasion patterns or toolkits exploited, it also assists in preventing access to actual devices by simulating the genuine systems and applications functioning in the network thus delaying as well as baffling the invader. In order to analyze and evaluate the hackers’ behavior, an ensemble of research honeypot detectors has been deployed in our work. This paper delivers a robust outline of the deployment of containerized honeypot deployment, as a direct consequence, these are portable, durable, and simple to deploy and administer. The instrumented approach was monitored and generated countless data points on which significant judgments about the malevolent users’ activities and purpose could be inferred.
An mTOR feedback loop mediates the ‘flare’ (‘rebound’) response to MET tyrosine kinase inhibition
Authors: Altintas D. M. , Cerqua M. , De Laurentiis A. , Trusolino L. , Boccaccio C. , Comoglio P. M.
Published: January 2023

Targeted therapy significantly impairs tumour growth but suffers from limitations, among which the ‘flare’ (‘rebound’) effect. Among cancers driven by tyrosine kinase receptors, those relying on alterations of the MET oncogene benefit from treatment by specific inhibitors. Previously, we reported that discontinuation of MET tyrosine kinase receptor inhibition causes ‘rebound’ activation of the oncogene, with a post-treatment transient hyperphosphorylation phase that culminates into a dramatic increase in cancer cell proliferation. The molecular mechanisms behind the ‘MET burst’ after treatment cessation are unknown but critically important for patients. Here we identify a positive feedback loop mediated by the AKT/mTOR pathway leading to (a) enhanced MET translation by activating p70S6K and 4EBP1 and (b) MET hyper-phosphorylation by inactivation of the tyrosine-phosphatase PTP1B. The latter effect is due to m-TOR-driven PTP1B phosphorylation of the inhibitory residues Ser50 and Ser378. These data provide in vitro evidence for the use of mTOR inhibitors to prevent the ’flare effect’ in MET targeted therapy, with potential applicative ramifications for patient clinical management.
Association between resilience and advance care planning during the COVID-19 pandemic in Japan: a nationwide cross-sectional study
Authors: Miyashita Jun , Takeshima Taro , Maehara Kazuhira , Hamaguchi Sugihiro , Fukuhara Shunichi
Published: January 2023

Advance care planning (ACP) is essential for end-of-life care, especially during the novel coronavirus disease 2019 (COVID-19) pandemic, and resilience is critical to deal with pandemic-related stressors. Therefore, we investigated the association between resilience ability and ACP discussions during the COVID-19 pandemic. A nationwide web-based survey was conducted in July 2021 in Japan. We analyzed the respondents’ ability to bounce back from stress (bouncing-back ability), positive stress coping (e.g., “seeking social support”, “planning”), and negative stress coping (e.g., “avoidance”, “alcohol and drug use”) in relation to ACP discussions using multivariable logistic regression models. In total, 2000 responses (86% participation rate) were received (mean age: 51.8 ± 16.7). Normal and high bouncing-back ability (adjusted odds ratio [AOR]: 1.69, 95% CI: 1.03–2.79; AOR: 2.07, 95% CI: 1.18–3.65, respectively) were significantly associated with the occurrence of ACP discussions. Seeking social support and planning were significantly associated with ACP discussions, whereas avoidance and alcohol and drug use were not. Both bouncing-back ability and positive stress coping were significantly associated with the occurrence of ACP discussions during the COVID-19 pandemic in Japan. These findings could be useful for aiding health-care providers involved in ACP discussions during the COVID-19 pandemic.
Modification of termination of resuscitation rule with compression time interval in South Korea
Authors: Park Song Yi , Lim Daesung , Ryu Ji Ho , Kim Yong Hwan , Choi Byungho , Kim Sun Hyu
Published: January 2023

This study aimed to validate the predictive performance of the termination of resuscitation (TOR) rule and examine the compression time interval (CTI) as a criterion for modifying the rule. This retrospective observational study analyzed adult out-of-hospital cardiac arrest (OHCA) patients attended by emergency medical service (EMS) providers in mixed urban–rural areas in Korea in 2020 and 2021. We evaluated the predictive performance of basic life support (BLS) and the Korean Cardiac Arrest Research Consortium (KoCARC) TOR rule using the false-positive rate (FPR) and positive predictive value (PPV). We modified the age cutoff criterion and examined the CTI as a new criterion. According to the TOR rule, 1827 OHCA patients were classified into two groups. The predictive performance of the BLS TOR rule had an FPR of 11.7% (95% confidence interval (CI): 5.9–17.5) and PPV of 98.4% (97.6–99.2) for mortality, and an FPR of 3.6% (0.0–7.8) and PPV of 78.6% (75.9–81.3) for poor neurological outcomes at hospital discharge. The predictive performance of the KoCARC TOR rule had an FPR of 5.0% (1.1–8.9) and PPV of 98.9% (98.0–99.8) for mortality, and an FPR of 3.7% (0.0–7.8) and PPV of 50.0% (45.7–54.3) for poor neurological outcomes at hospital discharge. The modified cutoff value for age was 68 years, with an area under the receiver operating characteristic curve over 0.7. In the group that met the BLS TOR rule, the cutoff of the CTI for death was not determined and was 21 min for poor neurological outcomes. In the group that met the KoCARC TOR rule, the cutoff of the CTI for death and poor neurological outcomes at the time of hospital discharge was 25 min and 21 min, respectively. The BLS TOR and KoCARC TOR rules showed inappropriate predictive performance for mortality and poor neurological outcomes. However, the predictive performance of the TOR rule could be supplemented by modifying the age criterion and adding the CTI criterion of the KoCARC.
Mucoadhesive chitosan–methylcellulose oral patches for the treatment of local mouth bacterial infections
Authors: Bonetti Lorenzo , Caprioglio Alice , Bono Nina , Candiani Gabriele , Altomare Lina
Published: January 2023

Electrophoretic deposition allows obtaining gentamicin-loaded chitosan–methylcellulose patches (CS–MC/GS) with distinctive mucoadhesive and antibacterial characteristics, useful to treat mouth bacterial infections.
On the disparity in reporting Li-rich layered oxide cathode materials
Authors: Lin Tongen , Seaby Trent , Huang Xia , Wang Lianzhou
Published: January 2023

Standard protocols of chemical compositions, synthesis pathways, calcination conditions, electrode preparation, battery fabrication, and battery testing are recommended in researching lithium-rich layered cathode materials for Li-ion batteries.
Research progress of auxiliary groups in improving the performance of fluorescent probes
Authors: Luo Canxia , Zhang Qi , Sun Shiguo , Li Hongjuan , Xu Yongqian
Published: January 2023

The auxiliary group of fluorescenct probes plays an important role in detection. According to the different mechanisms of interaction between auxiliary groups and analytes, we summarize three ways in which auxiliary groups improve the performance of fluorescent probes.
Electronic effects in the dissociative ionisation of pyrene clusters
Authors: Garcia Gustavo A. , Dontot Léo , Rapacioli Mathias , Spiegelman Fernand , Bréchignac Philippe , Nahon Laurent , Joblin Christine
Published: January 2023

We present a combined experimental and theoretical study on the dissociative ionisation of clusters of pyrene that shows non-statistical behaviour and suggests that the role of excited states must be considered in the interpretation of the results.