bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitochondria-targeted Probes for Imaging Protein Sulfenylation
Authors: Holmila Reetta J. , Vance Stephen A. , Chen Xiaofei , Wu Hanzhi , Shukla Kirtikar , Bharadwaj Manish S. , Mims Jade , Wary Zack , Marrs Glen , Singh Ravi , Molina Anthony J. , Poole Leslie B. , King S. Bruce , Furdui Cristina M.
Published: April 2018

Mitochondrial reactive oxygen species (ROS) are essential regulators of cellular signaling, metabolism and epigenetics underlying the pathophysiology of numerous diseases. Despite the critical function of redox regulation in mitochondria, currently there are limited methods available to monitor protein oxidation in this key subcellular organelle. Here, we describe compounds for imaging sulfenylated proteins in mitochondria: DCP-NEt2-Coumarin (DCP-NEt2C) and rhodamine-based DCP-Rho1. Side-by-side comparison studies are presented on the reactivity of DCP-NEt2C and DCP-Rho1 with a model protein sulfenic acid (AhpC-SOH) and mitochondrial localization to identify optimized experimental conditions for labeling and visualization of protein sulfenylation that would be independent of mitochondria membrane potential and would not impact mitochondrial function. These probes are applied to image mitochondrial protein sulfenylation under conditions of serum starvation and in a cell culture model of lung cancer exposed to ionizing radiation and silver nanoparticles, agents serving dual functions as environmental stressors and cancer therapeutics.
In situ full-field measurement of surface oxidation on Ni-based alloy using high temperature scanning probe microscopy
Authors: Li Yan , Fang Xufei , Qu Zhe , Lu Siyuan , Li Haicheng , Zhu Ting , Yu Qingmin , Feng Xue
Published: April 2018

We use in situ scanning probe microscopy (SPM) to investigate the high temperature oxidation of Ni-based single crystal alloys at the micro-/nanoscale. SiO2 micro-pillar arrays were pre-fabricated on the alloy surface as markers before the oxidation experiment. The SPM measurement of the oxidized surface in the vicinity of SiO2 micro-pillars was conducted real time at temperatures from 300 °C to 800 °C. The full-field evolution of oxide film thickness is quantitatively characterized by using the height of SiO2 micro-pillars as reference. The results reveal the non-uniform oxide growth featuring the nucleation and coalescence of oxide islands on the alloy surface. The outward diffusion of Ni and Co is responsible for the formation and coalescence of first-stage single-grain oxide islands. The second-stage of oxidation involves the formation and coalescence of poly-grain oxide islands.
Lifestyle index for mortality prediction using multiple ageing cohorts in the USA, UK and Europe
Authors: Liao Jing , Muniz-Terrera Graciela , Scholes Shaun , Hao Yuantao , Chen Yu-ming
Published: April 2018

Current mortality prediction indexes are mainly based on functional morbidity and comorbidity, with limited information for risk prevention. This study aimed to develop and validate a modifiable lifestyle-based mortality predication index for older adults. Data from 51,688 participants (56% women) aged ≥50 years in 2002 Health and Retirement Study, 2002 English Longitudinal Study of Ageing and 2004 Survey of Health Ageing and Retirement in Europe were used to estimate coefficients of the index with cohort-stratified Cox regression. Models were validated across studies and compared to the Lee index (having comorbid and morbidity predictors). Over an average of 11-year follow-up, 10,240 participants died. The lifestyle index includes smoking, drinking, exercising, sleep quality, BMI, sex and age; showing adequate model performance in internal validation (C-statistic 0.79; D-statistic 1.94; calibration slope 1.13) and in all combinations of internal-external cross-validation. It outperformed Lee index (e.g. differences in C-statistic = 0.01, D-statistic = 0.17, P < 0.001) consistently across health status. The lifestyle index stratified participants into varying mortality risk groups, with those in the top quintile having 13.5% excess absolute mortality risk over 10 years than those in the bottom 50th centile. Our lifestyle index with easy-assessable behavioural factors and improved generalizability may maximize its usability for personalized risk management.
Author Correction: Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin
Authors: Desai Jyaysi , Foresto-Neto Orestes , Honarpisheh Mohsen , Steiger Stefanie , Nakazawa Daigo , Popper Bastian , Buhl Eva Miriam , Boor Peter , Mulay Shrikant R. , Anders Hans-Joachim
Published: April 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Author Correction: Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method
Authors: Kim Jeong In , Kim Ju Yeon , Park Chan Hee
Published: April 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease
Authors: Zambrano Laura M. G. , Brandao Dayane A. , Rocha Fernanda R. G. , Marsiglio Raquel P. , Longo Ieda B. , Primo Fernando L. , Tedesco Antonio C. , Guimaraes-Stabili Morgana R. , Rossa Junior Carlos
Published: April 2018

There is evidence indicating that curcumin has multiple biological activities, including anti-inflammatory properties.In vitroandin vivostudies demonstrate that curcumin may attenuate inflammation and the connective tissue destruction associated with periodontal disease. Most of these studies use systemic administration, and considering the site-specific nature of periodontal disease and also the poor pharmacodynamic properties of curcumin, we conducted this proof of principle study to assess the biological effect of the local administration of curcumin in a nanoparticle vehicle on experimental periodontal disease. We used 16 rats divided into two groups of 8 animals according to the induction of experimental periodontal disease by bilateral injections of LPS or of the vehicle control directly into the gingival tissues 3×/week for 4 weeks. The same volume of curcumin-loaded nanoparticles or of nanoparticle vehicle was injected into the same sites 2×/week. µCT analysis showed that local administration of curcumin resulted in a complete inhibition of inflammatory bone resorption and in a significant decrease of both osteoclast counts and of the inflammatory infiltrate; as well as a marked attenuation of p38 MAPK and NF-kB activation. We conclude that local administration of curcumin-loaded nanoparticles effectively inhibited inflammation and bone resorption associated with experimental periodontal disease.
Calibrating facial morphs for use as stimuli in biological studies of social perception
Authors: Windhager Sonja , Bookstein Fred L. , Mueller Hanna , Zunner Elke , Kirchengast Sylvia , Schaefer Katrin
Published: April 2018

Studies of human social perception become more persuasive when the behavior of raters can be separated from the variability of the stimuli they are rating. We prototype such a rigorous analysis for a set of five social ratings of faces varying by body fat percentage (BFP). 274 raters of both sexes in three age groups (adolescent, young adult, senior) rated five morphs of the same averaged facial image warped to the positions of 72 landmarks and semilandmarks predicted by linear regression on BFP at five different levels (the average, ±2 SD, ±5 SD). Each subject rated all five morphs for maturity, dominance, masculinity, attractiveness, and health. The patterns of dependence of ratings on the BFP calibration differ for the different ratings, but not substantially across the six groups of raters. This has implications for theories of social perception, specifically, the relevance of individual rater scale anchoring. The method is also highly relevant for other studies on how biological facial variation affects ratings.
The transcription factor Spores Absent A is a PKA dependent inducer of Dictyostelium sporulation
Authors: Yamada Yoko , Cassidy Andrew , Schaap Pauline
Published: April 2018

Sporulation in Dictyostelium fruiting bodies evolved from amoebozoan encystation with both being induced by cAMP acting on PKA, but with downstream components still being unknown. Using tagged mutagenesis to find missing pathway components, we identified a sporeless mutant defective in a nuclear protein, SpaA. Expression of prespore genes was strongly reduced in spaA- cells, while expression of many spore stage genes was absent. Chromatin immunoprecipitation (ChIP) of a SpaA-YFP gene fusion showed that (pre)spore gene promoters bind directly to SpaA, identifying SpaA as a transcriptional regulator. SpaA dependent spore gene expression required PKA in vivo and was stimulated in vitro by the membrane-permeant PKA agonist 8Br-cAMP. The PKA agonist also promoted SpaA binding to (pre)spore promoters, placing SpaA downstream of PKA. Sequencing of SpaA-YFP ChIPed DNA fragments revealed that SpaA binds at least 117 (pre)spore promoters, including those of other transcription factors that activate some spore genes. These factors are not in turn required for spaA expression, identifying SpaA as the major trancriptional inducer of sporulation.
Whole exome sequencing reveals rare variants linked to congenital pouch colon
Authors: Mathur Praveen , Medicherla Krishna Mohan , Chaudhary Spandan , Patel Mruduka , Bagali Prashanth , Suravajhala Prashanth
Published: April 2018

We demonstrate the application of whole exome sequencing to discover the rare variants for congenital pouch colon, acronymed CPC. For 18 affected individuals in a total of 64 samples, we sequenced coding regions to a mean coverage of 100×. A sufficient depth of ca. 94% of targeted exomes was achieved. Filtering against the public SNP/variant repositories, we identified a host of candidate genes, EPB41L4A and CTC1 associated with colon, neural/brain muscles and Dyskeratosis Congenita maladies. Furthermore, the stop gain mutations in the form of JAG1,OR5AR1,SLC22A24,PEX16,TSPAN32,TAF1B,MAP2K3 and SLC25A19 appears to be localized to Chromosomes 2, 11, 17 and 20 in addition to the three stop lost mutations across three genes, viz. OAS2, GBA3 and PKD1L2 affecting the colon tissue. While our results have paved way for transcendence of monogenic traits in identifying the genes underlying rare genetic disorders, it will provide helpful clues for further investigating genetic factors associated with anorectal anomalies, particularly CPC.
Author Correction: Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells
Authors: Panigrahi Gati K. , Praharaj Prakash P. , Peak Taylor C. , Long Jessica , Singh Ravi , Rhim Johng S. , Abd Elmageed Zakaria Y. , Deep Gagan
Published: April 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
An Innovative Approach for The Integration of Proteomics and Metabolomics Data In Severe Septic Shock Patients Stratified for Mortality
Authors: Cambiaghi Alice , Díaz Ramón , Martinez Julia Bauzá , Odena Antonia , Brunelli Laura , Caironi Pietro , Masson Serge , Baselli Giuseppe , Ristagno Giuseppe , Gattinoni Luciano , de Oliveira Eliandre , Pastorelli Roberta , Ferrario Manuela
Published: April 2018

In this work, we examined plasma metabolome, proteome and clinical features in patients with severe septic shock enrolled in the multicenter ALBIOS study. The objective was to identify changes in the levels of metabolites involved in septic shock progression and to integrate this information with the variation occurring in proteins and clinical data. Mass spectrometry-based targeted metabolomics and untargeted proteomics allowed us to quantify absolute metabolites concentration and relative proteins abundance. We computed the ratio D7/D1 to take into account their variation from day 1 (D1) to day 7 (D7) after shock diagnosis. Patients were divided into two groups according to 28-day mortality. Three different elastic net logistic regression models were built: one on metabolites only, one on metabolites and proteins and one to integrate metabolomics and proteomics data with clinical parameters. Linear discriminant analysis and Partial least squares Discriminant Analysis were also implemented. All the obtained models correctly classified the observations in the testing set. By looking at the variable importance (VIP) and the selected features, the integration of metabolomics with proteomics data showed the importance of circulating lipids and coagulation cascade in septic shock progression, thus capturing a further layer of biological information complementary to metabolomics information.
IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity
Authors: Takamori Ayako , Nambu Aya , Sato Keiko , Yamaguchi Sachiko , Matsuda Kenshiro , Numata Takafumi , Sugawara Takeru , Yoshizaki Takamichi , Arae Ken , Morita Hideaki , Matsumoto Kenji , Sudo Katsuko , Okumura Ko , Kitaura Jiro , Matsuda Hiroshi , Nakae Susumu
Published: April 2018

IL-31, which is a member of the IL-6 family of cytokines, is produced mainly by activated CD4+ T cells, in particular activated Th2 cells, suggesting a contribution to development of type-2 immune responses. IL-31 was reported to be increased in specimens from patients with atopic dermatitis, and IL-31-transgenic mice develop atopic dermatitis-like skin inflammation, which is involved in the pathogenesis of atopic dermatitis. However, the role of IL-31 in development of contact dermatitis/contact hypersensitivity (CHS), which is mediated by hapten-specific T cells, including Th2 cells, is not fully understood. Therefore, we investigated this using IL-31-deficient (Il31−/−) mice, which we newly generated. We demonstrated that the mice showed normal migration and maturation of skin dendritic cells and induction of hapten-specific T cells in the sensitization phase of FITC-induced CHS, and normal induction of local inflammation in the elicitation phase of FITC- and DNFB-induced CHS. On the other hand, those mice showed reduced scratching frequency and duration during FITC- and/or DNFB-induced CHS. Our findings suggest that IL-31 is responsible for pruritus, but not induction of local skin inflammation, during CHS induced by FITC and DNFB.
Artisanal shark fishing in Milne Bay Province, Papua New Guinea: biomass estimation from genetically identified shark and ray fins
Authors: Appleyard S. A. , White W. T. , Vieira S. , Sabub B.
Published: April 2018

Our study is the first detailed examination of species composition using DNA COI barcoding of elasmobranchs from an artisanal fishery of Papua New Guinea. The study is the first in the region to provide biomass estimates based on species confirmation following examination of dried fins. Over 20 species of elasmobranchs were identified from 623 fins from the artisanal fishery in Milne Bay Province of PNG, withCarcharhinus amblyrhynchosandCarcharhinus melanopterusthe most abundant species in the catches. Of concern, 21% of fins examined were from IUCN listed threatened species (Vulnerable or Endangered) with 8% of fins from the Endangered scalloped hammerhead (Sphyrna lewini). Following species identifications and use of species-specific length and weight extrapolations, we estimated over 9 t of elasmobranchs contributed to the fin batch. Importantly, the vast majority of the elasmobranchs in this batch were from immature animals. Genetic identification has an important role to play in the ongoing sustainable management of elasmobranchs in artisanal fisheries in PNG and more widely. However in the absence of ongoing genetic testing, recording the species (if known) at the time of catch is more achievable and would provide more robust data for fisheries managers in PNG over the longer term.
Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T1 MRI Contrast in Liver Cell Lines
Authors: Saowalak Krungchanuchat , Titipun Thongtem , Somchai Thongtem , Chalermchai Pilapong
Published: April 2018

Herein, a new molecular nanoparticle based on iron(III)-tannic complexes (Fe–TA NPs) is presented. The Fe–TA NPs were simply obtained by mixing the precursors in a buffered solution at room temperature, and they exhibited good physicochemical properties with capability of inducing autophagy in both hepatocellular carcinoma cells (HepG2.2.15) and normal rat hepatocytes (AML12). The Fe–TA NPs were found to induce HepG2.2.15 cell death via autophagic cell death but have no effect on cell viability in AML12 cells. This is possibly due to the much higher uptake of the Fe–TA NPs by the HepG2.2.15 cells via the receptor-mediated endocytosis pathway. As a consequence, enhancement of the T1 MRI contrast was clearly observed in the HepG2.2.15 cells. The results demonstrate that the Fe–TA NPs could provide a new strategy combining diagnostic and therapeutic functions for hepatocellular carcinoma. Additionally, because of their autophagy-inducing properties, they can be applied as autophagy enhancers for prevention and treatment of other diseases.
The effect of attention and working memory on the estimation of elapsed time
Authors: Polti Ignacio , Martin Benoît , van Wassenhove Virginie
Published: April 2018

Psychological models of time perception involve attention and memory: while attention typically regulates the flow of events, memory maintains timed events or intervals. The precise, and possibly distinct, roles of attention and memory in time perception remain debated. In this behavioral study, we tested 48 participants in a prospective duration estimation task while they fully attended to time or performed a working memory (WM) task. We report that paying attention to time lengthened perceived duration in the range of seconds to minutes, whereas diverting attention away from time shortened perceived duration. The overestimation due to attending to time did not scale with durations. To the contrary, increasing WM load systematically decreased subjective duration and this effect scaled with durations. Herein, we discuss the dissociation between attention and WM in timing and scalar variability from the perspective of Bayesian models of time estimations.
Staphylococcus aureus enterotoxins modulate IL-22-secreting cells in adults with atopic dermatitis
Authors: Orfali Raquel Leao , da Silva Oliveira Luanda Mara , de Lima Josenilson Feitosa , de Carvalho Gabriel Costa , Ramos Yasmim Alefe Leuzzi , Pereira Natalli Zanete , Pereira Naiura Vieira , Zaniboni Mariana Colombini , Sotto Mirian Nacagami , da Silva Duarte Alberto José , Sato Maria Notomi , Aoki Valeria
Published: April 2018

Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by skin colonization byStaphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of antimicrobial peptide (AMP) production. We aimed to evaluate the impact of staphylococcal enterotoxins on the Tc22/Th22 induction in the peripheral blood of AD patients and on CD4+/CD8+T cells expressing IL-22 in AD skin. Our study showed inhibition of the staphylococcal enterotoxins A and B (SEA and SEB) response by Th22 (CD4+IL-22+IL-17A−IFN-γ−) cells in AD patients. In contrast, Tc22 (CD8+IL-22+IL-17A−IFN-γ−) cells were less susceptible to the inhibitory effects of staphylococcal enterotoxins and exhibited an enhanced response to the bacterial stimuli. In AD skin, we detected increased IL-22 transcript expression and T lymphocytes expressing IL-22. Together, our results provide two major findings in response to staphylococcal enterotoxins in adults with AD: dysfunctional CD4+IL-22 secreting T cells and increased Tc22 cells. Our hypothesis reinforces the relevance of CD8 T cells modulated by staphylococcal enterotoxins as a potential source of IL-22 in adults with AD, which is relevant for the maintenance of immunological imbalance.
Understanding Am3+/Cm3+separation with H4TPAEN and its hydrophilic derivatives: a quantum chemical study
Authors: Huang Pin-Wen , Wang Cong-Zhi , Wu Qun-Yan , Lan Jian-Hui , Song Gang , Chai Zhi-Fang , Shi Wei-Qun
Published: April 2018

Quantum chemical calculations have been used to help understand the back-extraction and separation of Am3+/Cm3+with H4TPAEN and its two hydrophilic derivatives.
A technique for a nano-textured gapless microlens array using self-formation characteristics of anodic alumina
Authors: Park Yong Min , Jang Woong Ki , Shin Tae Hwan , Kim Byeong Hee , Seo Young Ho
Published: April 2018

This paper presents a method to utilize the growth properties of anodic alumina possessing self-formation characteristics to fabricate a nano-textured microstructure and also introduces an application technique of the proposed method.
Carrier recombination and plasmonic emission channels in metallic photoluminescence
Authors: Wang Jiyong , Gürdal Emre , Horneber Anke , Dickreuter Simon , Kostcheev Sergei , Meixner Alfred J. , Fleischer Monika , Adam Pierre-Michel , Zhang Dai
Published: April 2018

Metallic photoluminescence from Au plasmonic nanoantennas is observed to encompass two emission channels: the electron–hole-pair recombination and the particle plasmons.
The enhanced angiogenesis effect of VEGF-silk fibroin nanospheres-BAMG scaffold composited with adipose derived stem cells in a rabbit model
Authors: Zhang Dongliang , Cao Nailong , Zhou Shukui , Chen Zhong , Zhang Xinru , Zhu Weidong
Published: April 2018

The adipose derived stem cells (ADSCs) was composited with vascular endothelial growth factor (VEGF)-silk fibroin (SF) nanospheres-bladder acellular matrix graft (BAMG) scaffold to repair bladder defect in rabbits.
Kinetics study of heterogeneous continuous-flow nitration of trifluoromethoxybenzene
Authors: Wen Zhenghui , Yang Mei , Zhao Shuainan , Zhou Feng , Chen Guangwen
Published: April 2018

Trifluoromethoxybenzene (TFMB) nitration was studied in a microreactor, furnishing kinetic data that promoted the process development of large-scale synthesis.
Pre-concentration and determination of cadmium and lead ions in real water, soil and food samples using a simple and sensitive green solvent-based ultrasonic assisted dispersive liquid–liquid microextraction and graphite furnace atomic absorption spectrometry
Authors: Ghorbani Mahdi , Akbarzade Samaneh , Aghamohammadhasan Mohsen , Seyedin Orkideh , Afshar Lahoori Nahid
Published: April 2018

A green solvent-based ultrasonic assisted dispersive liquid–liquid microextraction (GS-UADLLME) was developed for preconcentration of cadmium and lead ions from various real water, soil and food samples.
Development of novel enantioselective HPLC methods for the determination of the optical purity of Nα-Fmoc/Boc amino acid derivatives (Nα-PADs) of natural and unnatural amino acids: an analytical strategy for the key starting materials of therapeutic peptides
Authors: Komaravolu Yagnakirankumar , Dama Venugopala Rao , Maringanti Thirumala Chary
Published: April 2018

Chiral HPLC methods for natural and unnatural Nα-Fmoc/Boc amino acid derivatives used in therapeutic peptides.
Dual-functional imprinted magnetic nanoprobes for fluorescence detection of N-nitrosodiphenylamine
Authors: Hu Yufeng , Liu Jie , Li Junyu , Chen Tao , Wu Minghuo
Published: April 2018

Fluorescent magnetic molecularly imprinted nanoprobes were developed for the detection of N-nitrosodiphenylamine.
Photo-thermal reactions of ethanol over Ag/TiO2catalysts. The role of silver plasmon resonance in the reaction kinetics
Authors: Nadeem M. A. , Idriss H.
Published: April 2018

Photo-thermal catalytic reactions of ethanol over Ag/TiO2were conducted in order to probe into the role of plasmonic resonance response in the reaction kinetics.
Origins of halogen effects in bioorthogonal sydnone cycloadditions
Authors: Tao Huimin , Liu Fang , Zeng Ruxin , Shao Zhuzhou , Zou Lufeng , Cao Yang , Murphy Jennifer M. , Houk K. N. , Liang Yong
Published: April 2018

In bioorthogonal sydnone cycloadditions, the fluorine substituent dramatically increases the reactivity of sydnone mainly by lowering its distortion energy (see blue arrow).
Synthesis of multi-substituted dihydrofurans via palladium-catalysed coupling between 2,3-alkadienols and pronucleophiles
Authors: Tsukamoto Hirokazu , Ito Kazuya , Doi Takayuki
Published: April 2018

Multi-substituted dihydrofurans were obtained from a palladium-catalysed coupling reaction between 2,3-alkadienols and ketones bearing an electron-withdrawing group at the α-position.
Why lamivudine assembles into double-stranded helices in crystals: salt heterosynthon versus base-pairing homosynthon
Authors: da Silva Cameron Capeletti , Valdo Ana K. , do Nascimento Neto José Antônio , Ribeiro Leandro , Sarotti Ariel M. , Martins Felipe Terra
Published: April 2018

Here we were interested in obtaining a better understanding of the competition between the salt heterosynthon and the base-pairing homosynthon formed by the anti-HIV drug lamivudine in the presence of strong acids.
How does the total charge and isomerism influence the Ru–NO ammine complexes?
Authors: Pereira Orenha Renato , Tfouni Elia , Galembeck Sérgio Emanuel
Published: April 2018

The NO bioavailability is controlled from Ru–NO complexes, and thus, the influence of the total charge and ligands is explored from DFT calculations.
On the origin of the photocurrent of electrochemically passivated p-InP(100) photoelectrodes
Authors: Goryachev Andrey , Gao Lu , van Veldhoven René P. J. , Haverkort Jos E. M. , Hofmann Jan P. , Hensen Emiel J. M.
Published: April 2018

The evaluation of faradaic efficiencies is essential to unambiguously determine the origin of photocurrents as showcased for electrochemically conditioned p-InP.
A newly developed highly selective Zn2+–AcO− ion-pair sensor through partner preference: equal efficiency under solitary and colonial situation
Authors: Karar Monaj , Paul Suvendu , Biswas Bhaskar , Majumdar Tapas , Mallick Arabinda
Published: April 2018

Here we are reporting the identification and capturing of an ion-pair, ZnII–AcO−, in differential ionic crowd with high-fidelity and extreme selectivity, employing a synthesized receptor molecule, HBP.
Novel paramagnetic clays obtained through intercalation of Gd3+-complexes
Authors: Marchesi Stefano , Carniato Fabio , Bisio Chiara , Tei Lorenzo , Marchese Leonardo , Botta Mauro
Published: April 2018

The intercalation of two positively charged Gd3+-complexes into the interlamellar layer of synthetic saponite leads to a novel class of paramagnetic clays with good thermal stability and enhanced relaxometric properties.
A new structure family of oxide-ion conductors Ca0.8Y2.4Sn0.8O6 discovered by a combined technique of the bond-valence method and experiments
Authors: Inoue Ryota , Fujii Kotaro , Shiraiwa Masahiro , Niwa Eiki , Yashima Masatomo
Published: April 2018

Mg3TeO6-type Ca0.8Y2.4Sn0.8O6 was found as a new structure family of oxide-ion conductors by BVE calculations followed by experiments.
Synthesis of unsymmetrical multi-aroyl derivatives of ferrocene using palladium catalysed oxidative C–H aroylation
Authors: Deb Mayukh , Hazra Susanta , Gupta Ajay , Elias Anil J.
Published: April 2018

Palladium catalysed oxidative C–H aroylation of ferrocene: accessing the multi-aroyl derivatives of ferrocene.
A cancer specific oxaliplatin-releasing Pt(iv)-prodrug
Authors: Reshetnikov Viktor , Arkhypov Anton , Julakanti Purushottam Reddy , Mokhir Andriy
Published: April 2018

A highly efficient cancer specific Pt(iv) prodrug was developed.
Three new super water-stable lanthanide–organic frameworks for luminescence sensing and magnetic properties
Authors: Tong Wen-Quan , Liu Ting-Ting , Li Gao-Peng , Liang Ji-Ye , Hou Lei , Wang Yao-Yu
Published: April 2018

Three new lanthanide compounds, [Ln(HL)(H2O)3]n (1-Ln) (Ln = Eu, Tb and Dy), with isostructural structures have been constructed by a semi-rigid ligand 1-(3,5-dicarboxylatobenzyl)-3,5-pyrazole dicarboxylic acid (H4L) and Ln(NO3)3·6H2O using the solvothermal method.
trans-A2B-corrole bearing 2,3-di(2-pyridyl)quinoxaline (DPQ)/phenothiazine moieties: synthesis, characterization, electrochemistry and photophysics
Authors: Kandhadi Jaipal , Yan Wei-Cong , Cheng Fan , Wang Hui , Liu Hai-Yang
Published: April 2018

Singlet–singlet energy transfer and electron transfer processes in corrole–phenothiazine and corrole–DPQ dyads were demonstrated by using electrochemical and fluorescence (steady-state and time-resolved) spectral studies.
Seven luminescent metal–organic frameworks constructed from 5-(triazol-1-yl)nicotinic acid: luminescent sensors for CrVI and MnO4− ions in an aqueous medium
Authors: Yan Yang-Tian , Cao Feng , Zhang Wen-Yan , Zhang Si-Si , Zhang Fang , Wang Yao-Yu
Published: April 2018

Seven new luminescent metal–organic frameworks were assembled and complex 2 shows high selectivity and sensitivity for CrO42−, Cr2O72− and MnO4− ions with low detection limits.
An embedded neutral layer for advanced surface affinity control in grapho-epitaxy directed self-assembly
Authors: Delachat Florian , Gharbi Ahmed , Pimenta-Barros Patricia , Fouquet Antoine , Claveau Guillaume , Posseme Nicolas , Pain Laurent , Nicolet Célia , Navarro Christophe , Cayrefourcq Ian , Tiron Raluca
Published: April 2018

This work developed an innovative process for grapho-epitaxy DSA which enables independent control of the template surface affinities.
Near-infrared laser mediated modulation of ice crystallization by two-dimensional nanosheets enables high-survival recovery of biological cells from cryogenic temperatures
Authors: Panhwar Fazil , Chen Zhongrong , Hossain S. M. Chapal , Wang Meng , Haider Zeeshan , Memon Kashan , Chen Pengpeng , Zhao Gang
Published: April 2018

GO and MoS2nanosheets aided photothermal rewarming can recover biological cells from cryogenic temperatures with high survival rates and full functions.
Low-threshold lasing from colloidal CdSe/CdSeTe core/alloyed-crown type-II heteronanoplatelets
Authors: Gao Yuan , Li Mingjie , Delikanli Savas , Zheng Haiyang , Liu Baiquan , Dang Cuong , Sum Tze Chien , Demir Hilmi Volkan
Published: April 2018

An efficient solution processed laser is achieved via type-II quasi-2D heteronanoplatelets.
Insight into the mechanism of the photoluminescence of carbon nanoparticles derived from cryogenic studies
Authors: Malyukin Yuriy , Viagin Oleg , Maksimchuk Pavel , Dekaliuk Mariia , Demchenko Alexander
Published: April 2018

The origin of the fluorescence of carbon dots is the formation of self-trapped excitons in H-aggregate-like structures.
Diselenoamino acid derivatives as GPx mimics and as substrates of TrxR:in vitroandin silicostudies
Authors: Sudati Jéssie Haigert , Nogara Pablo Andrei , Saraiva Rogério Aquino , Wagner Caroline , Alberto Eduardo Eliezer , Braga Antonio Luiz , Fachinetto Roselei , Piquini Paulo Cesar , Rocha João Batista Teixeira
Published: April 2018

The antioxidants diselenoamino acid derivatives from phenylalanine and valine are mimetics of GPx and substrate of TrxR.
Chemo-enzymatic synthesis of isotopically labeled nicotinamide riboside
Authors: Tran Ai , Yokose Ryota , Cen Yana
Published: April 2018

A versatile chemo-enzymatic synthesis of isotopically labeled nicotinamide riboside (NR) was developed.
Interrogation of biosynthetic pathways of the cruciferous phytoalexins nasturlexins with isotopically labelled compounds
Authors: Pedras M. Soledade C. , To Q. Huy
Published: April 2018

A biosynthetic map of the precursors of the phytoalexins nasturlexins and cyclonasturlexin is established.
Biomimetic antimicrobial polymers: recent advances in molecular design
Authors: Ergene Cansu , Yasuhara Kazuma , Palermo Edmund F.
Published: April 2018

The increasing prevalence of antibiotic-resistant bacterial infections, coupled with the decline in the number of new antibiotic drug approvals, has created a therapeutic gap that portends an emergent public health crisis.
Photoinduced controlled radical polymerization of methyl acrylate and vinyl acetate by xanthate
Authors: Li Jiajia , Pan Xiangqiang , Li Na , Zhu Jian , Zhu Xiulin
Published: April 2018

A block copolymer of PMA-b-PVAc was successfully synthesized using photo-induced RAFT polymerization with a xanthate.
Redox-triggered hydrogels revealing switchable stiffness properties and shape-memory functions
Authors: Fadeev Michael , Davidson-Rozenfeld Gilad , Biniuri Yonatan , Yakobi Ravit , Cazelles Rémi , Aleman-Garcia Miguel Angel , Willner Itamar
Published: April 2018

Metal-ion terpyridine-crosslinked acrylamide hydrogels or metal-ion-bridged carboxymethylcellulose hydrogels reveal redox-switchable stiffness and shape-memory properties.
Pharmacological inhibition of fatty acid-binding protein 4 (FABP4) protects against renal ischemia-reperfusion injury
Authors: Shi Min , Huang Rongshuang , Guo Fan , Li Lingzhi , Feng Yanhuan , Wei Zhengjie , Zhou Li , Ma Liang , Fu Ping
Published: April 2018

FABP4 inhibition might attenuate I/R-induced AKI through reducing ER stress and apoptosis.
Different graphene layers to enhance or prevent corrosion of polycrystalline copper
Authors: Xu Ying , Qu Jingyi , Shen Yongtao , Feng Wei
Published: April 2018

The degree of corrosion depends on the crystal faces and number of graphene layers, whereas BLG can be used as an anticorrosion coating.
Optical properties and ionic conductivity studies of an 8 MeV electron beam irradiated poly(vinylidene fluoride-co-hexafluoropropylene)/LiClO4electrolyte film for opto-electronic applications
Authors: L. Yesappa , M. Niranjana , P. Ashokkumar S. , H. Vijeth , M. Basappa , Dwivedi Jishnu , Petwal V. C. , S. Ganesh , H. Devendrappa
Published: April 2018

A study into the effect of 8 MeV energy electron beam irradiation on the optical properties and ionic conductivity of a PVDF–HFP/LiClO4electrolyte film.
Highly efficient degradation of phenol from wastewater via an electro-catalytic oxidation approach with a CeO2–CuO cathode
Authors: Luo Jiankang , Zhang Huan , Li Zenghe
Published: April 2018

The development of highly efficient cathode materials for the electro-catalytic oxidation of phenol from wastewater is of vital importance for environment protection.
One-step nondestructive functionalization of graphene oxide paper with amines
Authors: Alzate-Carvajal Natalia , Acevedo-Guzmán Diego A. , Meza-Laguna Victor , Farías Mario H. , Pérez-Rey Luis A. , Abarca-Morales Edgar , García-Ramírez Victor A. , Basiuk Vladimir A. , Basiuk Elena V.
Published: April 2018

Solvent-free functionalization of graphene oxide paper with amines is facile, nondestructive, and attractive from economic and environmental points of view.
Bismuth film electrode and chloranilic acid as a new alternative for simple, fast and sensitive Ge(iv) quantification by adsorptive stripping voltammetry
Authors: Grabarczyk Malgorzata , Adamczyk Marzena
Published: April 2018

An analytical procedure regarding the voltammetric determination of germanium(iv) by adsorptive stripping voltammetry (AdSV) exploiting thein situplated bismuth film electrode (BiFE) is described.
An electrochemical anodization strategy towards high-activity porous MoS2 electrodes for the hydrogen evolution reaction
Authors: Mao Xuerui , Xiao Tianliang , Zhang Qianqian , Liu Zhaoyue
Published: April 2018

An electrochemical anodization strategy was developed for the formation of MoS2 electrodes for the hydrogen evolution reaction.
Rigid TiO2−xcoated mesoporous hollow Si nanospheres with high structure stability for lithium-ion battery anodes
Authors: Yu Yongli , Li Gang , Chen Xu , Lin Weiguo , Rong Junfeng , Yang Wensheng
Published: April 2018

A conductive TiO2−xshell suppresses the outward expansion of Si to maintain high interfacial stability and structural integrity.
Diphenylpyrenylamine-functionalized polypeptides: secondary structures, aggregation-induced emission, and carbon nanotube dispersibility
Authors: EL-Mahdy Ahmed F. M. , Kuo Shiao-Wei
Published: April 2018

PBLG chains to pyrene-DPA-2NH2 turned on a radiative pathway for the non-fluorescent molecule and TEM revealed these polypeptides with carbon nanotube to form PBLG/MWCNT composite.
Controlling destructive quantum interference in tunneling junctions comprising self-assembled monolayers via bond topology and functional groups
Authors: Zhang Yanxi , Ye Gang , Soni Saurabh , Qiu Xinkai , Krijger Theodorus L. , Jonkman Harry T. , Carlotti Marco , Sauter Eric , Zharnikov Michael , Chiechi Ryan C.
Published: April 2018

Three different benzodithiophene derivatives were designed to isolate the effects of bond topology from that of functional groups in quantum interference to examine the role of the quinone functionality separate from cross-conjugation.
Non-competitive cyclic peptides for targeting enzyme–substrate complexes
Authors: McAllister T. E. , Yeh T.-L. , Abboud M. I. , Leung I. K. H. , Hookway E. S. , King O. N. F. , Bhushan B. , Williams S. T. , Hopkinson R. J. , Münzel M. , Loik N. D. , Chowdhury R. , Oppermann U. , Claridge T. D. W. , Goto Y. , Suga H. , Schofield C. J. , Kawamura A.
Published: April 2018

Tight, non-active site binding cyclic peptides are promising affinity reagents for studying proteins and their interactions.
Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution
Authors: Zatolochnaya Olga V. , Rodríguez Sonia , Zhang Yongda , Lao Kendricks S. , Tcyrulnikov Sergei , Li Guisheng , Wang Xiao-Jun , Qu Bo , Biswas Soumik , Mangunuru Hari P. R. , Rivalti Daniel , Sieber Joshua D. , Desrosiers Jean-Nicolas , Leung Joyce C. , Grinberg Nelu , Lee Heewon , Haddad Nizar , Yee Nathan K. , Song Jinhua J. , Kozlowski Marisa C. , Senanayake Chris H.
Published: April 2018

A new class of tunable heterophosphole dimeric ligands have been designed and synthesized.
Isolable iodosylarene and iodoxyarene adducts of Co and their O-atom transfer and C–H activation reactivity
Authors: Hill Ethan A. , Kelty Margaret L. , Filatov Alexander S. , Anderson John S.
Published: April 2018

We report an unusual series of discrete iodosyl- and iodoxyarene adducts of Co(ii) including detailed studies of their O-transfer reactivity and mechanism.
Trapping [PMo12O40]3− clusters into pre-synthesized ZIF-67 toward MoxCoxC particles confined in uniform carbon polyhedrons for efficient overall water splitting
Authors: Chen Congfang , Wu Aiping , Yan Haijing , Xiao Yinglu , Tian Chungui , Fu Honggang
Published: April 2018

A new trapping route has been used to synthesize MoxCoxC confined in carbon polyhedrons, through trapping PMo12 clusters into pre-synthesized ZIF-67 polyhedrons. The catalysts showed excellent performance for water splitting.
Ionically cross-linked PEDOT:PSS as a multi-functional conductive binder for high-performance lithium–sulfur batteries
Authors: Yan Longlong , Gao Xiguang , Thomas Joseph Palathinkal , Ngai Jenner , Altounian Haig , Leung Kam Tong , Meng Yuezhong , Li Yuning
Published: April 2018

Mg2+ cross-linked conductive polymer PEDOT:PSS is used as a cathode binder to improve the Li–S battery capacity and cycling stability.
Electric field mediated elastic contact lithography of thin viscoelastic films for miniaturized and multiscale patterns
Authors: Ghosh Abir , Bandyopadhyay Dipankar , Sharma Ashutosh
Published: April 2018

Combination of elastic contact lithography (ECL) and electric field lithography (EFL) have shown significant potential to develop higher aspect ratio large-area micro-/nanopatterns on polymeric surfaces.
High-efficiency organic solar cells based on a small-molecule donor and a low-bandgap polymer acceptor with strong absorption
Authors: Yang Yankang , Qiu Beibei , Chen Shanshan , Zhou Qiuju , Peng Ying , Zhang Zhi-Guo , Yao Jia , Luo Zhenghui , Chen Xiaofeng , Xue Lingwei , Feng Liuliu , Yang Changduk , Li Yongfang
Published: April 2018

An OSC based on a small molecule DR3TBDTT as donor and n-type polymer PZ1 as acceptor was fabricated, and PCE of the device reached 5.86% which is the highest for the OSCs based small molecule donor/polymer acceptor.
Dual-functional carbon dot-labeled heavy-chain ferritin for self-targeting bio-imaging and chemo-photodynamic therapy
Authors: Yao Hanchun , Zhao Weiwei , Zhang Suge , Guo Xiaofang , Li Ying , Du Bin
Published: April 2018

Dual-functional carbon dots were synthesized for bio-imaging and photodynamic therapy; HFn(DOX)/CDs were used for simultaneous imaging and chemo-photodynamic therapy.
Self-assembled multiferroic epitaxial BiFeO3–CoFe2O4 nanocomposite thin films grown by RF magnetron sputtering
Authors: Kim Tae Cheol , Ojha Shuchi , Tian Guo , Lee Seung Han , Jung Hyun Kyu , Choi Jun Woo , Kornblum Lior , Walker Frederick J. , Ahn Charles H. , Ross Caroline A. , Kim Dong Hun
Published: April 2018

Sputter-grown self-assembled epitaxial spinel–perovskite nanocomposites consisting of CoFe2O4 pillars in a BiFeO3 matrix on Nb-doped SrTiO3 or SrTiO3-buffered Si substrates.
Electron transport at the interface of organic semiconductors and hydroxyl-containing dielectrics
Authors: Jiang Huihong , Huang Zhuoting , Xue Guobiao , Chen Hongzheng , Li Hanying
Published: April 2018

High electron transport can be obtained at the interface of organic semiconductors and hydroxyl-containing dielectrics.
Angiotensin-(1–7) reduces cardiac effects of thyroid hormone by GSK3Β/NFATc3 signaling pathway
Authors: Senger Nathalia , Melo Marcos Barrouin , Diniz Gabriela Placoná , Campagnole-Santos Maria José , Santos Robson Augusto Souza , Barreto-Chaves Maria Luiza M.
Published: April 2018

Patients with hyperthyroidism exhibit increased risk of development and progression of cardiac diseases. The activation of the renin–angiotensin system (RAS) has been indirectly implicated in these cardiac effects observed in hyperthyroidism. Angiotensin-(1–7) (Ang-(1–7)) has previously been shown to counterbalance pathological effects of angiotensin II (Ang II). The aim of the present study was to investigate the effects of elevated circulating Ang-(1–7) levels on cardiac effects promoted by hyperthyroidism in a transgenic rat (TG) model that constitutively overexpresses an Ang-(1–7)-producing fusion protein [TGR(A1-7)3292]. TG and wild-type (WT) rats received daily injections (i.p.) of triiodothyronine (T3; 7 µg/100 g of body weight (BW)) or vehicle for 14 days. In contrast with WT rats, the TG rats did not develop cardiac hypertrophy after T3 treatment. Indeed, TG rats displayed reduced systolic blood pressure (SBP) and cardiac hyperdynamic condition induced by hyperthyroidism. Moreover, increased plasma levels of Ang II observed in hyperthyroid WT rats were prevented in TG rats. TG rats were protected from glycogen synthase kinase 3β (GSK3β) inactivation and nuclear factor of activated T cells (NFAT) nuclear accumulation induced by T3. In vitro studies evidenced that Ang-(1–7) prevented cardiomyocyte hypertrophy and GSK3β inactivation induced by T3. Taken together, these data reveal an important cardioprotective action of Ang-(1–7) in experimental model of hyperthyroidism.
Asteroseismic and orbital analysis of the triple star system HD 188753 observed by Kepler
Authors: Marcadon F. , Appourchaux T. , Marques J. P.
Published: April 2018

Context. The NASA Kepler space telescope has detected solar-like oscillations in several hundreds of single stars, thereby providing a way to determine precise stellar parameters using asteroseismology.

Aims. In this work, we aim to derive the fundamental parameters of a close triple star system, HD 188753, for which asteroseismic and astrometric observations allow independent measurements of stellar masses.

Methods. We used six months of Kepler photometry available for HD 188753 to detect the oscillation envelopes of the two brightest stars. For each star, we extracted the individual mode frequencies by fitting the power spectrum using a maximum likelihood estimation approach. We then derived initial guesses of the stellar masses and ages based on two seismic parameters and on a characteristic frequency ratio, and modelled the two components independently with the stellar evolution code CESTAM. In addition, we derived the masses of the three stars by applying a Bayesian analysis to the position and radial-velocity measurements of the system.

Results. Based on stellar modelling, the mean common age of the system is 10.8 ± 0.2 Gyr and the masses of the two seismic components are MA = 0.99 ± 0.01 M⊙ and MBa = 0.86 ± 0.01 M⊙. From the mass ratio of the close pair, MBb/MBa = 0.767 ± 0.006, the mass of the faintest star is MBb = 0.66 ± 0.01 M⊙ and the total seismic mass of the system is then Msyst = 2.51 ± 0.02 M⊙. This value agrees perfectly with the total mass derived from our orbital analysis, Msyst = 2.51−0.18+0.20 M⊙, and leads to the best current estimate of the parallax for the system, π = 21.9 ± 0.2 mas. In addition, the minimal relative inclination between the inner and outer orbits is 10.9° ± 1.5°, implying that the system does not have a coplanar configuration.
Oscillations of cometary tails: a vortex shedding phenomenon?
Authors: Nisticò G. , Vladimirov V. , Nakariakov V. M. , Battams K. , Bothmer V.
Published: April 2018

Context. During their journey to perihelion, comets may appear in the field of view of space-borne optical instruments, showing in some cases a nicely developed plasma tail extending from their coma and exhibiting an oscillatory behaviour.

Aims. The oscillations of cometary tails may be explained in terms of vortex shedding because of the interaction of the comet with the solar wind streams. Therefore, it is possible to exploit these oscillations in order to infer the value of the Strouhal number S t, which quantifies the vortex shedding phenomenon, and the physical properties of the local medium.

Methods. We used the Heliospheric Imager (HI) data of the Solar TErrestrial Relations Observatory (STEREO) mission to study the oscillations of the tails of comets 2P/Encke and C/2012 S1 (ISON) during their perihelion in Nov 2013. We determined the corresponding Strouhal numbers from the estimates of the halo size, the relative speed of the solar wind flow, and the period of the oscillations.

Results. We found that the estimated Strouhal numbers are very small, and the typical value of S t ~ 0.2 would be extrapolated for size of the halo larger than ~106 km.

Conclusions. Although the vortex shedding phenomenon has not been unambiguously revealed, the findings suggest that some kind of magnetohydrodynamic (MHD) instability process is responsible for the observed behaviour of cometary tails, which can be exploited for probing the physical conditions of the near-Sun region.
Big Data Analytics: Towards a Model to Understand Development Equity for Villages in Indonesia
Authors: Vijaya Annas , Angreani Linda Salma , Hariyadi Mokhamad Amin
Published: April 2018

The aim of this paper is to design a prototype model that can be used to better understand development equity for villages in terms of public monitoring and evaluation. In designing the model, the research has reviewed several techniques of big data analytics as well as alignment of business strategic objectives and technology. The prototype model also tested using several types of data. Although some obstacles have found, as it also found in the reviewed literature, a prototype model which can guide researchers and practitioners to understand ways to capture public monitoring is presented in this paper. Furthermore, Information systems researchers could use this prototype model for further research to get a deeper understanding of big data analytics roles for development, particularly in developing countries.