bluuebunny/crossref_metadata_2025 huggingface dataset:
Laparoscopic Excision of Cesarean Scar Ectopic Pregnancy: An Optimum Management Option
Authors: Khoiwal Kavita , Sheoran Deepika , Mishra Ramya , Deshwali Akanksha , Chaturvedi Jaya
Published: May 2024

Cesarean scar ectopic pregnancy is a leading cause of life-threatening complications in the first trimester. It poses a diagnostic and management challenge; if not diagnosed and adequately treated in early pregnancy, it may lead to considerable maternal morbidity and mortality. We report a case series of cesarean scar ectopic pregnancies managed successfully by laparoscopy. Laparoscopic excision is the gold standard management approach for cesarean scar ectopic pregnancy.
Pasteurella multocida: An Uncommon Cause of Infective Endocarditis Affecting a Homograft Conduit in a Child
Authors: Ayoub Touseef Ul , Marwah Ashutosh , Iyer Parvathi U. , Iyer Krishna S. , Agarwal Anuradha
Published: May 2024

Background:

Disseminated septicemia and endocarditis are extremely rare complications of Pasteurella infection and are mainly seen in patients with associated major comorbidities.

Clinical Description:

A 13-year-old boy, who had undergone surgery for congenital heart disease in early childhood, presented with prolonged fever, gross hematuria, and oliguria. The child was found to be conscious and febrile, with tachycardia, pallor, and edema. There was a systolic murmur in the left upper sternal border with hepatosplenomegaly.

Management and Outcome:

Routine investigations revealed anemia, low serum albumin, and progressively worsening renal functions, with urinalysis showing significant proteinuria and red cells. Serial blood cultures showed growth of Pasteurella multocida. Echocardiography showed vegetation in conduit (homograft) connecting the right ventricle with the pulmonary artery. Despite intravenous antibiotics, the clinical condition did not improve, so the conduit was removed surgically, following which the child recovered.

Conclusion:

This case creates awareness regarding infective endocarditis in a child being caused by a rare organism P. multocida, involving a surgically created conduit. The case also highlights the importance of timely surgical removal of the source combined with a prolonged course of antibiotics in a successful recovery.
Divergent Phenotypes with Same CHRNE Mutation in Two Siblings with Congenital Myasthenic Syndrome
Authors: Naveen Ankith , Pujar Madhu S , Revankar Ranjitha , Rotti Shreya
Published: May 2024

Background:

Congenital myasthenic syndrome is a rare inherited neuromuscular disorder resulting in abnormal weakness and fatigue on exertion with onset at or shortly after birth or in early childhood.

Clinical Description:

A 2-year-old boy presented to us with respiratory failure, having a history of recurrent respiratory tract infections and underlying isolated motor delay. His 7-year-old elder sister had undiagnosed generalized weakness.

Management and Outcome:

While the index case was being stabilized with mechanical ventilation, his elder sibling was evaluated. Ptosis was noted in her, which improved with neostigmine. Examination and laboratory investigations ruled out other differentials. Clinical exome sequencing was sent which showed homozygous CHRNE ENST00000649488.2.c.1367_1369del. (p.Asn456del) resulting in acetylcholine receptor deficiency. Both siblings were started on oral pyridostigmine and salbutamol, resulting in improvement in muscle weakness over 3 months and 4 months in younger and older sibling, respectively.

Conclusion:

Recurrent respiratory insufficiency when associated with motor delay may be suggestive of a neuromuscular disorder. Even siblings with the same mutation may have different levels of severity of clinical manifestation.
Myasthenic Crisis in a Child: Successful Recovery after Early Identification and Intervention
Authors: Jaggi Ishmeet Kaur , Dewan Pooja , Harit Deepika , Kaushik Jaya Shankar , Yadav Mukesh
Published: May 2024

Background:

Juvenile myasthenia gravis (MG) is a rare autoimmune neuromuscular disorder and has a varied presentation in childhood making it a diagnostic challenge.

Clinical Description:

An 8-year-old girl presented to the pediatric emergency with multiple episodes of falling, drooling of saliva, dysphagia, and bilateral ptosis. Within a few hours of admission, she had acute deterioration, developed respiratory failure, and was put on ventilatory support.

Management and Outcome:

A myasthenic crisis was suspected and a neostigmine challenge test was done. She was managed in the emergency with atropine, neostigmine, intravenous immunoglobulin, and supportive care. Subsequently, she achieved complete remission with steroids, physostigmine, and oral mycophenolate mofetil over the next 6 weeks.

Conclusion:

Juvenile MG may rarely be the cause of generalized muscular weakness. A strong suspicion of myasthenic crisis must be kept in case of sudden deterioration involving bulbar and respiratory muscles, in a patient with neurologic weakness. Early intervention in this rare condition can be lifesaving.
Monogenic Autoinflammatory Disease Due to Blau Syndrome with Nucleotide Oligomerization Domain 2 Gene Mutation in an Indian Family
Authors: Magar Suvarna , Perveen Naziya , Kale Anjali , Agrawal Srishti
Published: May 2024

Background:

Blau syndrome is a monogenic disease resulting from mutations in nucleotide oligomerization domain 2 (NOD2) and is phenotypically characterized by a triad of dermatitis, arthritis, and uveitis. We report Blau syndrome in a child who had been symptomatic for years, without the typical clinical triad.

Clinical Description:

A 7-year-old girl child presented with bilateral knee, wrist, and ankle joint swelling since the age of 2 years. She had recently developed a rash on the body. Her mother, mother’s identical twin sister, and the latter’s 5-year-old daughter had similar joint pain and swellings since childhood. In view of the strong positive family history of polyarthritis, monogenic cause of arthritis was suspected.

Management and Outcome:

Complete blood count was unremarkable. Erythrocyte sedimentation rate was 20 mm at C-reactive protein was 36 mg/L, antinuclear antibody and rheumatoid arthritis factor were negative. X-ray of the knee joints and wrist joints showed soft-tissue swellings around the knee and lumbar scoliosis. A heterozygous pathogenic variant in NOD2 gene confirmed the diagnosis of Blau syndrome. After receiving the genetic report, the girl was started on prednisolone and weekly methotrexate.

Conclusion:

Early-onset arthritis, with recurrent episodes of fever, is not to be ignored if autoimmune markers are negative. Knowledge about the clinical features of autoinflammatory diseases and the spectrum of NOD2 variants will enable physicians to carry out specific investigations, especially genetic analysis for confirmation of the diagnosis and hence administer the right treatment.
Severe Hypertriglyceridemia in a Child with Refractory, Fatal Diabetic Ketoacidosis: A Case Report with Review of Literature
Authors: Soin Shyna , Kaur Gurmeet , Kaul Varun , Batra Dorthy
Published: May 2024

Background:

Diabetic ketoacidosis (DKA) is an acute life-threatening complication of diabetes. Dyslipidemia due to disturbance in glucose metabolism can cause elevation in serum triglyceride levels. Severe hypertriglyceridemia is a complication of DKA, rarely reported in children.

Clinical Description:

A 3-year-old girl, newly diagnosed, but untreated type 1 diabetes mellitus (DM), presented with DKA. The first blood sample showed serum as grossly milky, with highly raised levels of triglyceride (2170 mg/dL) and cholesterol (791 mg/dL). Many of the blood parameters were erroneous due to the lipemic sample. Serum amylase and lipase were normal, ruling out pancreatitis.

Management and Outcome:

Correction of dehydration, insulin infusion, antibiotics, and vasopressor support were started. Despite treatment with insulin and supportive care, the patient had a rapidly deteriorating course and ultimately succumbed to the illness.

Conclusion:

Uncontrolled, untreated DM in a child can result in decompensated DKA, which is usually associated with severe hypertriglyceridemia, and a rapidly progressive fatal course.
Streptococcus sinensis Causing Tricuspid Endocarditis in a Child: An Unusual Pathogen at an Unusual Site: A Case Report with Review of Literature
Authors: Manugu Navya Sree , Gadhiraju Manisha Varma , Chityala Stephen , Yerroju Kodandapani , Tummala Sadanand Reddy
Published: May 2024

Background:

Infective endocarditis (IE) involving tricuspid valve is rarely reported in children. Common etiological organisms of IE include Staphylococci, viridans group Streptococci, and Enterococci. Other less frequent organisms include Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, and Kingella (HACEK) group, and Candida, accounting for 1% of cases. We describe the rare case scenario of tricuspid valve endocarditis caused by an unusual pathogen.

Clinical Description:

An 8-year-old girl presented with complaints of cough, shortness of breath, and intermittent fever for the past 2 months. Since 10 days before presentation, the fever had become high grade, continuous, and associated with chills and rigors. As per parents, the child had incidentally been detected with some congenital heart disease (CHD) at 3 months of age, documents being unavailable, child remaining asymptomatic till this presentation, without any medications. On examination, the child was malnourished with pallor, Grade 3 clubbing, tachypnea, and tachycardia. Auscultation revealed bilateral basal crepitations and a pansystolic murmur of Grade 4 in tricuspid area.

Management and Outcome:

Along with routine investigations, a two-dimensional echocardiography was done which revealed perimembranous ventricular septal defect with left-to-right shunt, tricuspid valve vegetations with anterior tricuspid leaflet prolapse with ruptured chordea, severe tricuspid regurgitation, and thickened aortic valve with good biventricular function. Blood culture showed growth of Streptococcus sinensis. The child was treated with oxygen, diuretics, and intravenous ciprofloxacin and gentamicin according to antibiotic sensitivity pattern. The child became hemodynamically stable and symptomatically improved after 3 weeks of treatment.

Conclusion:

This case creates awareness regarding an usual pathogen – S. sinensis as an etiological agent of IE, involving an unusual site – the tricuspid valve, in a child with CHD.
An elderly woman with palpitations and delirium – A sinister pattern
Authors: Malviya Amit , Gupta Anunay , Berman Bhupen
Published: May 2024

Hyperkalemia can present in varied ways. Here, we discuss a life-threatening complications of hyperkalemia, which were promptly recognized and successfully managed.
An algorithmic approach to pulmonary function tests for cardiologists
Authors: Gureja Sarthak , Haque Amirul , Kumar Avi , Agrawal Rajat , Jain Peeyush
Published: May 2024

Pulmonary function tests (PFTs) and chest roentgenogram form a gateway to more advanced tests during diagnostic workup of a suspected respiratory disorder. Since the heart and lungs form an integrated physiological system, cardiovascular and pulmonary disorders coexist frequently. For this reason, and several other reasons, cardiologists should have an understanding of pulmonary function testing to manage their patients effectively. Interpreting PFTs may seem complex for a nonpulmonologist, but a systematic approach makes it really a simple process to facilitate a correct cardiopulmonary diagnosis in many instances.
An unintended connection – Radial arteriovenous fistula after coronary angiogram
Authors: Praveen G. , Khan Mohammed Fahad , Augustine Rohan , Siddini Vishwanath , Ballal H. Sudarshan
Published: May 2024

The following case is of a 44-year-old female undergoing maintenance hemodialysis (MHD) due to chronic interstitial nephritis, utilizing a left brachiocephalic (BC) arteriovenous fistula (AVF). Following presentation with retrosternal anginal pain, diagnosed as high lateral wall myocardial infarction, coronary angiogram revealed normal coronaries. Subsequently, dilated veins along the right forearm were noticed, attributed to a patent right radiocephalic AVF. Despite being asymptomatic, the patient underwent a Doppler ultrasound confirming a blood flow of 400 ml/min through the AVF. No further intervention was planned as the patient continued MHD through the left BC AVF.
Echocardiographic evaluation of mitral inflow e wave velocity-to-tissue Doppler e’ wave velocity ratio (E/e’) as a prognostic indicator in ST-elevation myocardial infarction
Authors: Bandil Vaibhav , Shrivastava Sameer , Sharma Vinay Kumar , Bhandari Suman
Published: May 2024

AIMS AND OBJECTIVES:

To study the clinical characteristics and to assess the usefulness of echocardiographic evaluation of mitral inflow E wave velocity-to-tissue Doppler e’ wave velocity ratio (E/e’) as a prognostic indicator in patients admitted with ST-elevation myocardial infarction (STEMI) with or without revascularization therapy to predict in-hospital mortality.

BACKGROUND:

Myocardial infarction is a high-risk condition, especially when filling pressure is raised, and earlier reports have suggested that E/e’ is associated with poor outcome. However, whether E/e’ predicts risk better than left ventricular ejection fraction (LVEF), which is the current standard of practice, is not known.

MATERIALS AND METHODS AND RESULTS:

The echocardiographic evaluation of mitral inflow E wave velocity-to-tissue Doppler e’ wave velocity ratio (E/e’) as a prognostic indicator in ST-elevation myocardial infarction” was carried out on 100 patients admitted in the Department of Cardiology of Fortis Escorts Heart Institute, Okhla, New Delhi, from November 2019 to March 2021. The mean age of the patients with ST-elevation myocardial infarction was 59.8 ± 11.3 years. In patients who had E/e’ >15, male predominance and higher age (mean 63.7 ± 7.7 years) were found. Out of common cardiovascular risk factors, smoking and diabetes mellitus were found to be statistically significant. 67.7% of patients were belonged to the Killip Class II or more. In patients who had E/e’ >15, 29 (93.5%) patients had LVEF ≤45%. Twenty-seven (87.1%) patients had deceleration time (DT) ≤140 ms. Moderate or severe mitral regurgitation (MR) was found in 19.4% of patients, while the mean values of LVEDD and LVESD were 50.4 ± 2.15 mm and 39.7 ± 3.3 mm, respectively. The mean velocity of E and A was 0.87 ± 0.12 m/s and 0.75 ± 0.11 m/s, respectively. The mean E/A ratio was 1.1 ± 0.22. The mean velocity of e’ was 5.02 ± 0.45 cm/s and E/e’ ratio was 17.48 ± 1.57. The association of various clinical features showed that male gender, higher age, smoking, and diabetes mellitus, cardiogenic shock, and Killip Class II or greater were significant factors associated with E/e’ >15. Echocardiographic findings showed that LVEF ≤45%, higher LVEDD and LVESD, higher peak E velocity, DT ≤140 ms, lower mitral annulus e’ velocity, higher E/e’ ratio, and moderate or severe MR were significantly associated with E/e’ >15.

CONCLUSION:

The current study concluded that Doppler echocardiographic estimation of E/e’ ratio can be used as a marker of elevated left ventricular filling pressure and hence can be used as a prognostic marker in risk stratification of patients admitted in coronary care units. The E/e’ ratio is an independent and powerful predictor of the in-hospital mortality.
Pineapple (Ananas comosus) Ameliorates Depressant-like Behaviors in Rats Induced by Lipopolysaccharide
Authors: Nurrahma Herlin Ajeng , Meliala Andreanyta , Vikawati Nura Eky , Narwidina Paramita , Supriyanto Irwan
Published: May 2024

Background:

Lipopolysaccharide (LPS) injection can lead to depression and mood disorders by reducing tryptophan availability through increased activity of the enzyme indoleamine 2,3-dioxygenase. Tryptophan, sourced from fruits such as pineapple (Ananas cosmosus), is vital for the body, especially the serotonergic system.

Aim:

This study aims to assess how pineapple pulp (PP) counters LPS-induced depressive behaviors in male Wistar rats.

Methods:

The experiment involved force-feeding PP for 28 days before LPS injection (0.5 mg/kg intraperitoneal [i.p.]) in 30 male Wistar rats, divided into five groups. Groups I (normal) and II (LPS control) received 15 ml aquadest/kg/day. Test Groups III, IV, and V were given varied doses of PP; low dose (3.75 ml/kg/day), medium dose (7.5 ml/kg/day), and high dose (15 ml/kg/day). At the study’s end, rats underwent the open field test (OFT) and the tail suspension test (TST). In addition, blood and brain samples were analyzed for neuroendocrine markers related to depression.

Results:

LPS triggers depressive symptoms, as evidenced by increased immobility time in the TST and altered behaviors indicative of anxiety in the OFT, especially in groups not receiving PP. This is followed by decreased serotonin levels in both plasma and brain when compared to groups given PP. In addition, higher corticosterone levels were observed in the LPS group than in the PP-treated group. Administering PP at 7.5 ml/kg/day for 28 days can alleviate the depressive effects induced by LPS injection.

Conclusion:

PP may have antidepressant properties, potentially by mitigating behaviors leading to depressive symptoms.
AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice
Authors: Hu Zhengwei , Yang Jing , Zhang Shuo , Li Mengjie , Zuo Chunyan , Mao Chengyuan , Zhang Zhongxian , Tang Mibo , Shi Changhe , Xu Yuming
Published: May 2024

JOURNAL/nrgr/04.03/01300535-202501000-00033/figure1/v/2024-12-10T152134Z/r/image-tiff

The E3 ubiquitin ligase, carboxyl terminus of heat shock protein 70 (Hsp70) interacting protein (CHIP), also functions as a co-chaperone and plays a crucial role in the protein quality control system. In this study, we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s disease. We used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse brain. CHIP overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests, reduced amyloid-β plaques, and decreased the expression of both amyloid-β and phosphorylated tau. CHIP also alleviated the concentration of microglia and astrocytes around plaques. In APP/PS1 mice of a younger age, CHIP overexpression promoted an increase in ADAM10 expression and inhibited β-site APP cleaving enzyme 1, insulin degrading enzyme, and neprilysin expression. Levels of HSP70 and HSP40, which have functional relevance to CHIP, were also increased. Single nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated, which may also reflect a potential mechanism for the neuroprotective effect of CHIP. Our research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 mice. Indeed, overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.
Non-coding RNAs in acute ischemic stroke: from brain to periphery
Authors: Li Shuo , Xu Zhaohan , Zhang Shiyao , Sun Huiling , Qin Xiaodan , Zhu Lin , Jiang Teng , Zhou Junshan , Yan Fuling , Deng Qiwen
Published: May 2024

Acute ischemic stroke is a clinical emergency and a condition with high morbidity, mortality, and disability. Accurate predictive, diagnostic, and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain undetermined. With innovations in high-throughput gene sequencing analysis, many aberrantly expressed non-coding RNAs (ncRNAs) in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental models. Differentially expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes, leading to neuroprotection or deterioration, thus ncRNAs can serve as therapeutic targets in acute ischemic stroke. Moreover, distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction, diagnosis, and prognosis. In particular, ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic stroke. In this review, we consolidate the latest progress of research into the roles of ncRNAs (microRNAs, long ncRNAs, and circular RNAs) in the pathological processes of acute ischemic stroke–induced brain damage, as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction, diagnosis, and prognosis. Findings from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.
MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits
Authors: Cui Yuehua , Ma Xiaokuang , Wei Jing , Chen Chang , Shakir Neha , Guirram Hitesch , Dai Zhiyu , Anderson Trent , Ferguson Deveroux , Qiu Shenfeng
Published: May 2024

JOURNAL/nrgr/04.03/01300535-202505000-00026/figure1/v/2024-07-28T173839Z/r/image-tiff

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration, however, few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function. We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis. To investigate whether enhancing MET in adult cortex has synapse regenerating potential, we created a knockin mouse line, in which the human MET gene expression and signaling can be turned on in adult (10–12 months) cortical neurons through doxycycline-containing chow. We found that similar to the developing brain, turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons. These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses. Prolonged MET signaling resulted in an increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-D-aspartate (AMPA/NMDA) receptor current ratio, indicative of enhanced synaptic function and connectivity. Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain. These findings may have implications for regenerative therapy in aging and neurodegeneration conditions.
Multisensory mechanisms of gait and balance in Parkinson’s disease: an integrative review
Authors: Roytman Stiven , Paalanen Rebecca , Carli Giulia , Marusic Uros , Kanel Prabesh , van Laar Teus , Bohnen Nico I.
Published: May 2024

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population. Posture and gait control does not happen automatically, as previously believed, but rather requires continuous involvement of central nervous mechanisms. To effectively exert control over the body, the brain must integrate multiple streams of sensory information, including visual, vestibular, and somatosensory signals. The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work. Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults. Insufficient emphasis, however, has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance. In the present work, we review the contributions of somatosensory, visual, and vestibular modalities, along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease. We also review evidence of vestibular contributions to multisensory temporal binding windows, previously shown to be highly pertinent to fall risk in older adults. Lastly, we relate multisensory vestibular mechanisms to potential neural substrates, both at the level of neurobiology (concerning positron emission tomography imaging) and at the level of electrophysiology (concerning electroencephalography). We hope that this integrative review, drawing influence across multiple subdisciplines of neuroscience, paves the way for novel research directions and therapeutic neuromodulatory approaches, to improve the lives of older adults and patients with neurodegenerative diseases.
Indian Thyroid society expert consensus on salt Iodisation
Authors: Pandav Chandrakant S. , Bajaj Sarita , Yadav Kapil , Joshi Shashank R , Seshadri Krishna G , Kalra Pramila , Rajput Rajesh , Ghosh Sujoy , Menon Arun S , Pillai Mini G. , Jabbar P K , Puri Surabhi , Gupta Sushil , Ganie Mohd Ashraf , Rao Himagirish K , Shenoy Mohan T. , Joshi Ameya
Published: May 2024

Iodine, an essential micronutrient, is crucial for the production of thyroid hormones - triiodothyronine(T3) and thyroxine(T4). Thyroid hormones regulate the optimum mental development, physical growth and development, regulation of body metabolism, heat generation, and maintenance of body temperaturein an individual. Geological processes like flooding, soil erosion, deforestation, and rivers changing course, deplete the surface soil of iodine, as it is present in the top layers of soil and easily soluble in water. As a result, the population residing in the area with iodine-deficient soil, becomes susceptible to a spectrum of functional and developmental abnormalities due to dietary deficiency of iodine. Universal Salt Iodization (USI) for prevention of IDDs in India is a public health success story. The adoption of the salt iodization strategy serves as a textbook example of the journey of an intervention through the iterative loop of research to policy to programme. Salt iodization has proved to be a safe, accessible, available, affordable, and cost-effective strategy to address the burden of IDDs in India. India has been at the forefront of the efforts to control IDDs globally. India is on its way to achieving the target of > 90 percent household coverage of adequately iodized salt. Revised Food Safety and Standards (Fortification of Foods) Regulations released in 2019 introduced an upper limit for iodine concentration in salt, the adequate iodine level required at the production and consumer level, including the distribution channel at 15 – 30 ppm. Universal Salt Iodisation (USI) is India’s public health success story. There is a need to consolidate progress so far and focus on strategy to reach the “last mile”. Sustainable elimination of Iodine Deficiency Disorders (IDDs) with Universal Salt Iodisation (USI) being the primary strategy needs to also factor in harmonisation with salt reduction strategy for control of non-communicable diseases.
Adaptive-Duplex Relay Selection for Cooperative Non-Orthogonal Multiple Access Networks
Authors: Zhao Jing , He Xiang
Published: May 2024

To further improve the spectral efficiency of the cooperative non-orthogonalmultiple access (NOMA) network with half-duplex (HD) relaying and avoid the zero diversity gain due to the imperfect self interference estimation at high signa-to-noise ratio (SNR) value with full-duplex (FD) relaying, this paper developed a novel two-stage relay selection for a two-user multi-relay cooperative NOMA systems with adaptive-duplex (AD) relaying which can switch opportunistically between HD and FD relaying modes. An adaptive duplexbased on a fixed power allocation factor relay selection (AD-FPA-RS) scheme for cooperative NOMA networks is proposed in this paper, the relay can switch the work mode to the FD or HD state adaptively according to the current channel state information and the result of decode at the relay. Furthermore, the exact outage probability for the proposed AD-FPA-RS scheme is obtained in a closed-form expression. The simulation and numerical results show that the proposed AD-FPA-RS scheme not only outperforms the existing HD-FPARS and FD-FPA-RS schemes in terms of outage behavior significantly but also can obtain full diversity gain without the floor outage performance at high SNR region.
Suicidal Ideation Detection and Influential Keyword Extraction from Twitter using Deep Learning (SID)
Authors: G. Xie-Yi.
Published: May 2024

INTRODUCTION: This paper focuses on building a text analytics-based solution to help the suicide prevention communities to detect suicidal signals from text data collected from online platform and take action to prevent the tragedy.
OBJECTIVES: The objective of the paper is to build a suicide ideation detection (SID) model that can classify text as suicidal or non-suicidal and a keyword extractor to extracted influential keywords that are possible suicide risk factors from the suicidal text.
METHODS: This paper proposed an attention-based Bi-LSTM model. An attention layer can assist the deep learning model to capture influential keywords of the model classifying decisions and hence reflects the important keywords from text which highly related to suicide risk factors or reason of suicide ideation that can be extracted from text.
RESULTS: Bi-LSTM with Word2Vec embedding have the highest F1-score of 0.95. Yet, attention-based Bi-LSTM with word2vec embedding that has 0.94 F1-score can produce better accuracy when dealing with new and unseen data as it has a good fit learning curve.
CONCLUSION: The absence of a systematic approach to validate and examine the keyword extracted by the attention mechanism and RAKE algorithm is a gap that needed to be resolved. The future work of this paper can focus on both systematic and standard approach for validating the accuracy of the keywords.
Invariant scalar-flat Kähler metrics on line bundles over generalized flag varieties
Authors: Yao Qi
Published: May 2024

Let G be a simply connected semisimple compact Lie group, let X be a simply connected compact Kähler manifold homogeneous under G, and let L be a negative holomorphic line bundle over X. We prove that all G-invariant Kähler metrics on the total space of L arise from the Calabi ansatz. Using this, we show that there exists a unique G-invariant scalar-flat Kähler metric in each G-invariant Kähler class of L. The G-invariant scalar-flat Kähler metrics are automatically asymptotically conical.
Меры Гиббса для плодородных моделей с жесткими взаимодействиями и с четырьмя состояниями
Authors: Khakimov Rustamjon Maxmudovich , Tozhiboev Bakhtier Zokirzhon ugli
Published: May 2024

Рассмотрены плодородные модели с жесткими взаимодействиями с четырьмя состояниями и параметром активности $\lambda>0$ на дереве Кэли. Известно, что существуют три типа таких моделей: "палка", "ключ" и "обобщенный ключ". Для модели "обобщенный ключ" на дереве Кэли порядка $k=4$ доказана единственность трансляционно-инвариантной меры Гиббса, а также найдены условия существования двупериодических мер Гиббса, отличных от трансляционно-инвариантных. Кроме того, в случае плодородного графа типа "палка" показана трансляционная инвариантность двупериодических мер Гиббса на дереве Кэли порядков $k=2,3,4$ и найдены условия существования двупериодических мер Гиббса, отличных от трансляционно-инвариантных, на дереве Кэли порядка $k\geq5$.
Обобщенные тета-ряды и монодромия связности Казимира. Случай ранга 1
Authors: Dotsenko Egor Ivanovich
Published: May 2024

Рассматривается монодромия $\mathfrak{sl}(2)$ связности Казимира. Показано, что след оператора монодромии по подходящему пространству плоских сечений дает тета-константу Якоби и неполные тета-функции. Дается определение новых объектов - неполных сумм Аппеля-Лерха, получена их связь со следом оператора монодромии.
Об иерархии $q$-деформированного модифицированного уравнения Кадомцева-Петвиашвили со связями: дополнительная симметрия и скрытая структура алгебры Вирасоро
Authors: Li Song , Tian Kelei , Xu Ying , Yi Ge
Published: May 2024

Построена дополнительная симметрия иерархии $q$-деформированного модифицированного уравнения Кадомцева-Петвиашвили со связями. Введен новый модифицированный оператор. Получены потоки и дополнительные потоки, действующие на модифицированный оператор. Представлены дополнительные потоки, действующие на собственную функцию и на сопряженную собственную функцию. Найдена скрытая структура алгебры Вирасоро в дополнительной симметрии иерархии $q$-деформированного модифицированного уравнения Кадомцева-Петвиашвили со связями.
Солитонные решения нелинейного уравнения Шредингера отрицательного порядка
Authors: Urazboev Gayrat Urazalievich , Baltaeva Iroda Ismailovna , Babadjanova Aygul Kamiljanovna
Published: May 2024

Рассматривается задача Коши для нелинейного уравнения Шредингера отрицательного порядка в классе быстро убывающих функций, интегрирование которой проводится методом обратной задачи рассеяния. В частности, получены зависимости от времени данных рассеяния для системы Захарова-Шабата с потенциалом, который является решением рассматриваемой задачи. На основе полученных результатов найдено в явном виде односолитонное решение нелинейного уравнения Шредингера отрицательного порядка.
John Locke o edukacji
Authors: Wrońska Katarzyna
Published: May 2024

Książka prezentuje studia nad myślą i życiem angielskiego filozofa i pedagoga Johna Locke’a oraz wybór jego pism poświęconych edukacji. Głównym celem tej badawczej i translacyjnej pracy jest zapoznanie polskiego czytelnika z szerszą wiedzą o edukacyjnych poglądach Locke’a i pogłębienie recepcji całości dzieła tego oświeceniowego myśliciela. Refleksja pedagogiczna, a także praktyczne zaangażowanie Locke’a w sprawy wychowania, kształcenia i opieki, które podejmował w swoim życiu, tworzą istotną część tego dzieła, bez nich niekompletnego i nie do zrozumienia w pełni. Publikacja dedykowana jest szerokiemu gronu badaczy i studentów, szczególnie tym zainteresowanym filozofią, historią i teorią edukacji, ale również wszystkim zatroskanym o jej dzisiejszy kształt.
ANALYSIS OF THE SHADOWS IMPACT ON PUBLIC SPORT FIELDS IN THE CITY OF KRAGUJEVAC
Authors:   KOSOVO AND METOHIJA ACADEMY OF APPLIED STUDIES, Stefanović Andreja , Mandič Lazar ,   University of Belgrade, Faculty of Architecture, Serbia
Published: May 2024

The size, shape, and articulation of buildings create shadows at different times of day and year that may limit the penetration of direct sunlight onto both public spaces. In this paper, the impact of shadows on public sport playgrounds in the city of Kragujevac was analyzed. Seven such playgrounds, located between multi-family buildings in the center of the city of Kragujevac, were included in study. The shadows impact was analyzed for September 21st and December 21st, since these playgrounds can be used throughout the year. The shadow impact criterion is based on the concept of the Sun Access Factor as a measure of Sun penetration on a given area, during a specified time frame. Based on the calculated values of the Sun Access Factor, an analysis of the shadows impact on the sports fields was performed by comparing it with the internationally used values
MASS REAL ESTATE VALUATION – ONE OF THE PILLARS OF THE 21ST CENTURY CADASTRE
Authors:   Republic Geodetic Authority, Serbia, Đorđević Ognjen , Kostić Nemanja ,   Republic Geodetic Authority, Serbia, Vasiljević Ilija ,   Republic Geodetic Authority, Serbia, Štrbac Ivana ,   Republic Geodetic Authority, Serbia
Published: May 2024

The value of real estate has been recognized by the United Nations as one of the four pillars of effective land administration. The real estate cadastre is one of the most important institutions of any country because it encompasses data about the most valuable property of a nation. It allows citizens to access up-to-date and verified information regarding real estate within a country's territory. In addition to information access, a modern cadastre covering all four pillars of land administration is essential for the registration of real estate and ownership, reflecting the economic activity of a state and its citizens, as well as for more reliable property tax calculation, which represents one of the main revenues of a state. Due to these factors, the Republic Geodetic Authority recognized the need for a unified system for collecting data from the real estate market, as well as developing models for the mass appraisal of all types of real estate in the Republic of Serbia. For the purpose of collecting necessary data, in 2012, the Republic Geodetic Authority developed the Real Estate Price Register aimed at gathering data on all traded real estate within the territory of the Republic of Serbia. Data collected in this way form the basis for the mass appraisal models. These models use the collected data on property characteristics and employ hedonic linear regression to predict the market value of real estate today. Besides predicting values, these models are also used to create the Real Estate Price Index, the main indicator of market trends.
LAND PARCEL - INFORMATION HOLDER INTEGRATING LAND MANAGEMENT DIGITAL DATA IN THE 21ST CENTURY
Authors:   Republic Geodetic Authority, Serbia, Matić Varenica Jelena , Rikanović Saša ,   Republic Geodetic Authority, Serbia, Šimunić Vanja ,   Republic Geodetic Authority, Serbia, Šimunović Željko ,   LANTMÄTERIET – The Swedish mapping, cadastral and land registration authority
Published: May 2024

In the 21st century, keeping pace with technological advancements, digitally stored and accessible information offers a wide range of opportunities. With the multidisciplinary nature of science and business, an increasing number of different fields recognize the significance and utilize various types of data. A cadastral parcel, as a key component of the National Spatial Data Infrastructure, can contain diverse types of information relevant to its identification, management, and utilization. By combining well-structured and geospatially oriented data, such as geographic, ownership, historical, legal, topographic, infrastructural, tax-related, and planning data, information retrieval at the parcel level is facilitated. Considering a parcel as an "information bearer," it underscores the interconnectedness between physical space and the associated data. The goal is for modern cadastral systems to integrate the National Spatial Data Infrastructure along with their subsystems, including geographic information systems, to efficiently manage and analyze parcel data, thus facilitating decision-making processes related to land administration, urban planning, real estate development, and resource management. The importance of data standardization becomes crucial for quality information management concerning parcels. Through the integration of artificial intelligence and machine learning, the future lies in creating smart cities that utilize parcel data for optimizing land use, planning infrastructure development, fostering sustainable communities and enhancing the quality of life for citizens. These are just some of the possibilities for parcels to become a rich source of information useful for various purposes, including urban planning, land management, sustainabile development, implementation and planning of fiscal policy, and transparent inclusion of population. The integration of technologies such as GIS, data analytics, and open data promises to enhance the ability to use parcel information for timely and informed decision-making.
REAL ESTATE MARKET IN THE REPUBLIC OF SERBIA: TRANSPARENCY AND ACCESSIBILITY OF AUTHORITATIVE DATAPAPER TITLE IN ENGLISH
Authors:   Republic Geodetic Authority, Serbia, Antić Jelena , Bendić Ivan ,   Republic Geodetic Authority, Serbia, Štrbac Ivana ,   Republic Geodetic Authority, Serbia
Published: May 2024

According to the Law on State Survey and Cadaster from 2011, the Republic Geodetic Authority was entrusted with the responsibility of assessment and management of real estate in the Republic of Serbia. As an institution with data access, in line with digitalization and improvement of land administration, during 2012, it began developing the Real Estate Price Register to collect sales contracts with the aim of developing a mass property valuation model. The Real Estate Price Register is the primary database for analyzing and reporting to the public on trends and movements in the real estate market in the territory of the Republic of Serbia. Reporting is enabled through public access to the Real Estate Price Register database, through reports on the real estate market status, and reports on price indices. Reports have been continuously published since 2014 with modified content. Reports from the Republic Geodetic Authority are used by all relevant institutions of the Republic of Serbia to report on trends and movements in real estate prices, as well as by the Bank for International Settlements (BIS) and the National Bank of Serbia in the Financial Stability Report. The final product of the Republic Geodetic Authority is the housing price index used as a parameter for monitoring real estate prices and economic development.
DIGITALIZATION AND INNOVATIONS IN REAL ESTATE CADASTRE: PERSPECTIVES OF THE 21ST CENTURY
Authors:   Republic Geodetic Authority, Serbia, Kanjo Marina , Knežević Miloš ,   Republic Geodetic Authority, Serbia, Živić Stefan ,   Republic Geodetic Authority, Serbia
Published: May 2024

The Republic Geodetic Authority, as the institution entrusted with the official records of real estate and property rights holders, as well as the management of geospatial data at the national level, is undergoing significant changes in the 21st century. Due to rapid technological advancement and the need for more efficient property management, it strives to provide services in a quality, transparent, and effective manner, constantly aligning its work with international standards and user needs. Through the Law on the Procedure of Registration in the Real Estate Cadastre and Cadastre of Infrastructure, the legal framework continues to be amended and further regulates the use of the eFrontDesk aiming for complete digitalization and electronic business transactions between the Republic Geodetic Authority and state bodies, citizens, businesses, and all other users of RGA data and services. In the sphere of digitalization of electronic business, the Republic Geodetic Authority has implemented significant changes in its operations by developing a large number of digital services, electronic business models available on the Republic Geodetic Authority website and the new RGA Portal. One of the most significant innovations is the implementation of international ISO 9001, 27001, and 27701 standards, ensuring efficient information management, data protection, and improving the quality system in working with users and other interested parties. Also, by constantly monitoring the work of real estate cadastre services and introducing new forms of reports, a constant increase in the work efficiency of the cadastre has been achieved. This theme will present the challenges and opportunities that arise during the transition to a digitized cadastre, including privacy, accessibility, and employee training issues. Through comprehensive analysis, this theme provides insight into how real estate cadastre becomes a key pillar of modern property management in the 21st century.
DVADESET GODINA RADA MEĐUNARODNOG NAUČNO-STRUČNOG SKUPA „LETNjA ŠKOLA URBANIZMA“
Authors: Minić Dušan , Jovanović Zoran  D.
Published: May 2024

Ove godine, Udruženje urbanista Srbije i Republički geodetski zavod obeležavaju izuzetan jubilej, 20 godina rada međunarodnog naučno-stručnog skupa „Letnje škole urbanizma“. Ovaj rad podseća i svedoči o veoma uspešnom radu Udruženja urbanista Srbije i Republičkog geodetskog zavoda u proteklih dvadeset godina na organizovanju međunarodnih naučno stručnih skupova, pod nazivom „ Letnja škola urbanizma“ Za to su zaslužni rukovodioci u Udruženju urbanista Srbije i rukovodioci u Republičkom geodetskom zavodu, ali za to su zaslužni i mnogobrojni strani i domaći stručnjaci – predavači, kao i veliki broj aktivni članovi Udruženja urbanista Srbije i zaposleni u Republičkom geodetskom zavodu. Ovaj rad čuva pamćenje na ostvarene izuzetne rezultate u oblasti planiranja i uređenja prostora, permanentnog obrazovanja i edukacije stručnjaka koji se bave i aktivno rade u ovoj i srodnim delatnostima, ali čuva pamćenje i na mnoge urbaniste, arhitekte, prostorne planere, inženjere građevinske, geodetske, saobraćajne, elektro, mašinske, ekologije i drugih struka,koji su bili predavači ili autori – koautori stručnih radova i referata na „Letnjoj školi urbanizma“ i koji su bili izuzetno posvećeni poslu kojim se bave. U prilogu ovog rada, nalazi se kompakt disk sa posebnim referatom koji je pripremljen , u vidu Monografije – 20 godina rada i postojanja međunarodnog naučno-stručnog skupa „LETNjA ŠKOLA URBANIZMA“. Ovaj referat- Monografija, prikazuje Letnju školu urbanizma, i njen rad sa svim podacima koji karakterišu njen rad u proteklih 20 godina i sadrži podatke; o mestu održavanja i organizatorima, o temama o kojima su se vodile stručne debate, o broju učesnika, o nazivima stručnih radova sa imenima autora za svaku Letnju školu urbanizma posebno, zatim sadrži i zvanične zaključke i saopštenja koja su usvajana na kraju rada svake Letnje škole i ista dostavljana nadležnim Ministarstvima, drugim državnim institucijama i organizacijama. Pored navedenog, Monografija sadrži i fotografije naslovnih strana Zbornika radova, određeni broj fotografija Sertifikata i određeni broj fotografija sa ovih skupova
Epithelioid Hemangioma: Report of a Case Series of 4 Patients
Authors: Aldás Eduardo Garzón
Published: May 2024

Epithelioid hemangioma or Angiolymphoid Hyperplasia with Eosinophilia (ALHE) is a rare benign vascular disease, characterized by solitary or multiple angiomatous papules and nodules, which are usually located on the skin of scalp and face (mainly in the preauricular zone); these have characteristic histological and immunohistochemical patterns, in particular characterized by an important lymphocytic inflammatory infiltrated with many eosinophils and vascular proliferation of capillaries with endothelial cellular changes. In this paper, four cases of this disease are reported, in the first series of Ecuadorian cases described in the literature.
Economic Empowerment: The Role of Digital Financial Inclusion in Boosting Gross National Income in Upper-Income Countries
Authors: Khan Ahsan Aslam , Ahmad Zaki , Abbas Raheel , Ahmad Mushtaq
Published: May 2024

The objective of this study is to examine the impact of the digital financial inclusion index on Gross National Income per Capita in upper-income countries. Using the Principal Components Analysis (PCA) method, the study has constructed a digital financial inclusion index with the data collected from the World Development Indicator for the years 2011–2021. Further, utilizing the Generalized Moments of Method (GMM) technique, the findings reveal a significant positive effect of the digital financial inclusion index on income levels, emphasizing the importance of inclusive financial systems for broader economic participation. Additionally, bank branches remain important, highlighting their complementary role alongside digital services. Moreover, savings significantly contribute to economic growth and stability. Lastly, ATMs play a positively significant role in raising economic development and increasing income levels. Policymakers should prioritise initiatives that enhance digital financial inclusion, strengthen traditional banking infrastructure, and encourage savings. Additionally, investments in accessible banking services, such as ATMs, can significantly contribute to advancing economic development and increasing income levels.