bluuebunny/crossref_metadata_2025 huggingface dataset:
DEVELOPMENT AND EVALUATION OF METFORMIN TABLETS: EFFECT OF SUPERDISINTEGRANTS
Authors:   Department of Pharmaceutics, PSG college of Pharmacy, Coimbatore – 641 004, Affiliated to the Tamilnadu Dr MGR Medical University, Chennai- 600 032, India, Veintramuthu Sankar , Annamalai Giridharan , Shikkandar Ashma
Published: April 2024

Metformin is an oral antihyperglycemic medication used to treat type 2 diabetes. BCS-III classification of medications includes metformin hydrochloride, which has a high solubility and a low permeability. This study’s objective was to develop wet granulated metformin hydrochloride tablets using various synthetic superdisintegrants. On disintegration and dissolution, the effects of different superdisintegrants have been studied. After evaluation, it were observed that post-compression properties such as weight variability, thickness, hardness, and friability were within the IP ranges. The formulation F4 with Croscarmellose sodium (CCS) in low concentration was chosen as the best formulation. By increasing the quantity of Croscarmellose sodium (CCS), the in vitro dissolution profile increased, and in vitro disintegration time also increased in the formulated tablets using wet granulation method. The statistical significance was determined using one-way ANOVA, and there is no significant difference between formulations.
PREPARATION AND EVALUATION OF COLON-SPECIFIC PROBIOTIC DELIVERY SYSTEM: SACCHAROMYCES BOULARDII
Authors:   Department of Pharmaceutics, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur- 247 341, Uttar Pradesh, India, Chauhan Seema B. , Singh Ranjit ,   Department of Pharmaceutics, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur- 247 341, Uttar Pradesh, India, Bajaj Himani ,   Department of Pharmaceutics, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur- 247 341, Uttar Pradesh, India
Published: April 2024

Probiotics are beneficial microbes that have a beneficial effect on humans as well as animals. Despite their advantages, probiotics face viability challenges during storage and while passing through the upper gastrointestinal tract. This study was designed to develop an encapsulated system of Saccharomyces boulardii (SB) probiotics to overcome challenges with oral administration and develop a colon-targeted delivery system. Pectin and sodium carboxy methyl cellulose encapsulated microbeads of probiotics: polymer ratio (1:1, 1:2, and 1:3) were prepared using the ionotropic gelation technique and then coated with Eudragit® S 100 and cellulose acetate phthalate. They were then evaluated for efficacy and compared for bead size, flow properties, entrapment efficiency, percent yield, swelling index, mucoadhesive ness, in vitro release and viability of probiotics. The microencapsulated probiotics showed higher viability in the colon as compared to gastric and intestinal environments. Hence, microencapsulation is a potential delivery system for the administration of viable probiotics
ADVANCING PARKINSON’S DISEASE DETECTION WITH FLISA: A NOVEL APPROACH TARGETING MISFOLDED ALPHA-SYNUCLEIN
Authors:   DBT-ICT Centre for Energy Biosciences, Institute of Chemical Technology, Mumbai - 400 019, Maharashtra, India, Batabyal Paramita , Sarangdhar Vishwas ,   Caius Research Laboratory, St. Xavier’s College, Mumbai – 400 001, Maharashtra, India, Sawner Ajay S. ,   Biological Sciences and Bioengineering, Indian Institute of Technology, Mumbai – 400 076, Maharashtra, India, Gadade Amruta V. ,   ICMR -National Centre for Preclinical Reproductive and Genetic Toxicology, Mumbai – 400 012, Maharashtra, India, Deshpande Radni D. ,   Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai – 400 019, Maharashtra, India, Dighe Vikas D. ,   ICMR -National Centre for Preclinical Reproductive and Genetic Toxicology, Mumbai – 400 012, Maharashtra, India, Sathaye Sadhana ,   Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai – 400 019, Maharashtra, India
Published: April 2024

A Fluorescence-Linked Immunosorbent Assay (FLISA) targeting β-cross-sheet α-synuclein protein, a crucial marker in Parkinson’s Disease (PD), was assessed using in vitro assay with a rotenone-induced PD cellular model. The study aimed to evaluate FLISA’s applicability with the inhouse developed labelled polyclonal antibody (pAb). Results are promising the competitive assay successfully distinguished misfolded α-synuclein in SH-SY5Y cells. Quantitative analysis revealed a direct correlation between competitive antigen concentration and decreased fluorescence, showcasing FLISA’s sensitivity. Controls exhibited maximal fluorescence, confirming the absence of misfolded proteins, while rotenone exposed cells displayed reduced fluorescence, suggesting their presence. This approach enhances PD understanding and supports potential interventions.
Development and Performance Evaluation of a Heart Disease Prediction Model Using Convolutional Neural Network
Authors: Esan Adebimpe , Akingbade Juwon , Omoniji Adetunji , Sobowale Adedayo , Adebiyi Tomilayo
Published: April 2024

Heart disease is a leading cause of mortality globally and its prevalence is increasing year after year. Recent statistics from the World Health Organization show that about 17.9 million individuals are embattled with heart diseases annually and people under the age of 70 account for one-third of these deaths. Hence, there is need to intensify research on early heart disease prediction and artificial intelligence-based heart disease prediction systems. Previous heart disease prediction systems using machine learning techniques are unable to manage large amount of data, resulting in poor prediction accuracy. Hence, this research employs Convolutional Neural Networks, a deep learning approach for prediction of heart diseases. The dataset for training and testing the model was obtained from a government owned hospital in Nigeria and Kaggle. The resulting system was evaluated using precision, recall, f1-score and accuracy metrics. The results obtained are: 0.94, 0.95, 0.95 and 0.95 for precision, recall, f1-score and accuracy respectively. This show that the CNN-based model responded very well to the prediction of heart diseases for both negative and positive classes. The results obtained were also compared to some selected machine-learning models like Random Forest, Naïve Bayes, KNN and Logistic Regression and results show that the developed model achieved a significant improvement over the methods considered. Therefore, convolutional neural network is more suitable for heart disease prediction than some state-of-the-art machine-learning models. The contribution to knowledge of this research is the use of Afrocentric dataset for heart disease prediction. Future research should consider increasing the data size for model training to achieve improved accuracy.
Unlocking the Power of Waste Cooking Oils for Sustainable Energy Production and Circular Economy: A Review
Authors: Okpo Samson Onoriode , Edafiadhe Emozino Donatus
Published: April 2024

In the pursuit for sustainable energy solutions, biodiesel has come to prominence as an alternative to petroleum-derived diesel. This review delves into cutting-edge developments in production of biodiesel, emphasizing use of waste cooking oils (WCOs) as an environmentally friendly raw material. Incorporating waste cooking oils (WCOs) into the biodiesel production process not only tackles environmental issues associated with improper disposal but also adheres to the principles of a circular economy. This manuscript covers various methods and technologies for converting WCOs into high-quality biodiesel, emphasizing economic viability and environmental benefits. It discusses the potential of WCO-derived biodiesel to meet stringent fuel standards and reduce greenhouse gas emissions. Significant progress has been made in using waste cooking oils to generate sustainable energy, aligning with broader initiatives focused on renewable energy and circular economy principles. In summary, the utilization of waste cooking oils for biodiesel production presents an opportunity to shift away from reliance on fossil fuels, thereby fostering circular economy practices and sustainability goals.
Influence of Extraction Temperature on the Quality of Neem Seed Oil: Preliminary Investigation
Authors: Usman John Goji , Okonkwo Paul Chidi , Mukhtar Bello , Baba Abdul
Published: April 2024

The storage of neem oil for a long time before usage comes along with challenge of quality retain ability of the oil; and the extraction methods can affect the quality of neem seed oil. This research work compared the mechanical expression method to the solvent extraction method to find a better method that will give high-grade neem oil for long-term storage. A plant with a capacity of 50 kg/day of neem seed kernel was used to extract oil from neem seed using ethanol as extraction solvent. The increase of extraction temperature from 20 oC (mechanically expressed) to 78 oC leads to decrease of iodine value from 62.70 to 60.10 gI2/100 g; increase of acid value from 3.4 to 4.2 mg KOH/g and increase of saponification value from 158.74 to 210.18 mgKOH/g. The Fames standard method was used for the GC – MS analysis and the percentage composition of the polyunsaturated components in the 20 oC (mechanically expressed), 50 oC, 55 oC, 60 oC and 78 oC oils were 21.58, 6.33, 3.09, 1.83 and 0.21% respectively. The changed of extraction temperature from 20 oC to 78 oC brings about reduction of polyunsaturated components from 21.58% to 0.21%. The increase of extraction temperature leads to conversion of unsaturated components to saturated components due to auto – oxidation process. This is clearly seen as the extraction temperature increased from 20 oC to 78 oC, the percentage composition of the saturated components increased from 22.40% to 43.70% and the polyunsaturated component decreased from 20.47% to 0%. The fatty acid composition associated with the 78 oC oil are: Oleic acid, 46.61%; Stearic acid, 11.83%; Palmitic acid, 16.54%; 11 – Octadecenoic acid, 3.58%; Cis – Vaccenic acid, 5.90%; Cyclopropaneoctanal, 11.19%; Squalene, 0.21% and Trimethylsilyl – di(timethylsiloxy) – silane, 4.14%. The functional groups identified in the 78 oC oil were C – H, C = O, C – C and C – O. Based on the lowest iodine value, lowest percentage composition of the polyunsaturated component value and high percentage composition of saturated component, the neem oil obtained at 78 oC from the miscella is considered as the high grade neem oil because it is less reactive due to lowest percentage composition of polyunsaturated and can be stored for long time before usage. Furthermore, the results from this work will assist manufacturers in selecting the extraction temperature for particular application of the neem seed oil. The extracted oil is recommended for soap production due to its high saponification value.
Perfil do paciente portador de hipotireoidismo na população de Araquari
Authors: Becker Miline Weis , Lovato Giovanna , Barreiros Barbara Kawall Connolly , Baggenstoss Rejane
Published: April 2024

Objetivo: investigar a prevalência dos principais fatores de risco nos pacientes portadores de hipotireoidismo em uma amostra da população brasileira.  Métodos:  Estudo retrospectivo observacional na Unidade Básica de Saúde Nicanor Corrente, localizada no município de Araquari, Santa Catarina. Os participantes no estudo consistiam em 410 pacientes portadores de hipotireoidismo. Por fim, foram totalizou-se 201 pacientes após aplicação dos seguintes de critérios de exclusão: menores de 18 anos e gestantes e pacientes que não utilizavam a medicação, falta de informações no prontuário, prontuários duplicados ou casos de óbito. Os dados foram coletados através da análise dos prontuários eletrônicos dos pacientes e, posteriormente, tabulados. A fim de avaliar sua influência na prevalência do hipotireoidismo, foram analisadas as seguintes variáveis: idade, sexo, etnia, hereditariedade, doenças autoimunes, deficiência de iodo, utilização de lítio, exposição à radiação ionizante, cirurgia de remoção da tireoide, tratamento para hipertireoidismo e ocupação profissional. Resultados: Foram analisados, por fim, um total de 201 pacientes com hipotireoidismo. A idade média dos pacientes foi de 54,76 anos. 84,58% eram do sexo feminino (N=170) e 15,42% do sexo masculino (N=31). A presença de doenças autoimunes no presente estudo ocorreu em 4,48% dos pacientes. 2,49% dos pacientes do estudo apresentam histórico de exposição à radiação ionizante (N=5) e 97,51% não relataram exposição (N=196). Com relação ao uso do lítio, 3,98% dos portadores de hipotireoidismo relataram uso de tal fármaco (N=8) e 96,02% não utilizam lítio (N=193). Conclusão: os fatores de risco apontados nas literaturas mundiais também se demonstraram presentes na população analisada, sendo que a maioria da amostra de pacientes apresentou, ao menos, algum dos fatores de risco descritos associados à sua patologia.
AUDIT OPERASIONAL ATAS PENGELOLAAN PERSEDIAAN CELANA JEANS PADA PERUSAHAAN PT MULTI GARMENJAYA CABANG PALEMBANG
Authors: Anisa Anisa , Hesthria Nur , Pajaria Yusiresita
Published: April 2024

Setiap perusahaan dalam melaksanakan kegiatan tidak terlepas dari kebutuhan akan barang dagangan yang menjadi faktor utama dalam kegiatan usaha seperti persediaan barang dagang dan pengelolaan persediaan. Persediaan yang merupakan aset terpenting dari bisnis dan pengelolaan persediaan untuk menentukan hasil penjualan agar mendapatkan laba dan diharapkan dapat menciptakan aktivitas pengelolaan terhadap perusahaan yang efektif dan efisien dalam menentukan jumlah persediaan yang dimiliki perusahaan secara optimal, mencegah berbagai tindakan pelanggaran dan penyelewengan. PT Multi Garmenjaya adalah perusahaan yang bergerak di bidang usaha garmen yaitu industri manufaktur pembuatan pakaian. Pengelolaan persediaan celana jeans yang terjadi pada PT Multi Garmenjaya di kota Palembang ini belum cukup efektif dan efisien karena adanya temuan beberapa masalah mulai dari proses terima barang jadi di showroom, minimnya stock persediaan sehingga terjadinya broken size dan tidak adanya rekap stock pada pengelolaan persediaan barang. Tujuan dalam penelitian ini adalah untuk mengetahui apakah audit operasional atas pengelolaan persediaan celana jeans pada perusahaan PT Multi Garmenjaya cabang Palembang sudah berjalan efektif dan efisien. Metode yang digunakan adalah metode penelitian kuantitatif. Metode analisis data yang digunakan adalah deskriptif kuantitatif. Hasil penelitian adalah bahwa audit operasional atas pengelolaan persediaan celana jeans pada perusahaan PT Multi Garmenjaya cabang Palembang belum efektif dan efisien dalam mengikuti Standar Operasional Prosedur (SOP) perusahaan, dan masih banyak kelemahan dan resiko yang ditemukan pada kegiatan operasional perusahaan ini yang dapat menghambat kegiatan operasional khususnya pada kegiatan pengelolaan persediaan celana jeans.
PENGARUH RASIO HUTANG DAN HARGA SAHAM TERHADAP BIAYA MODAL RATA-RATA TERTIMBANG PADA PERUSAHAAN SUB SEKTOR PERTAMBANGAN DI BURSA EFEK INDONESIA PERIODE 2016-2020
Authors: Vania Kalianda , Pratiwi Nurul Mardiyyah , Carolina Debi , Furqon Muhammad
Published: April 2024

Pengaruh rasio hutang, dan harga saham terhadap biaya modal rata-rata tertimbang pada perusahaan sub sektor pertambangan yang terdaftar di BEI. Biaya modal rata-rata tertimbang merupakan biaya ekuitas dari biaya hutang masing-masing dikalikan dengan persentase ekuitas dan hutang dalam struktur modal. Rumusan masalah dalam penelitian ini adalah bagaimana perkembangan masing- masing variabel rasio hutang, harga saham dan biaya modal rata-rata tertimbang. Bagaimana pengaruh rasio hutang, harga saham berpengaruh secara parsial dan simultan terhadap biaya modal rata-rata tertimbang pada perusahaan sub sektor pertambangan yang terdaftar di Bursa Efek Indonesia periode 2016-2020. Metode analisis data yang digunakan adalah deskriptif dan verifikatif. Hasil penelitian dapat disimpulkan bahwa secara parsial menunjukkan bahwa harga saham berpengaruh terdahap biaya modal rata-rata tertimbang sedangkan rasio hutang tidak berpengaruh terhadap biaya modal rata-rata tertimbang. Koefisien Determinasi (R2) adalah 85,8% dengan kata lain, dapat diartikan Pengaruh Rasio Hutang (X1), dan Harga Saham (X2) terhadap biaya modal rata-rata tertimbang (Y) sebesar 85,8% dan sisanya 14,2% yang dipengaruhi oleh variabel lain yang tidak diikutkan dalam penelitian ini.
PreventS-MD®: a New Digital Technology to Maintain Cardiovascular Prevention in Routine Clinical Practice
Authors: Kravchenko Mikhail A. , Gnedovskaya Elena V. , Feigin Valery L. , Piradov Mikhail A.
Published: April 2024

Stroke, myocardial infarction (MI), and other main non-communicable diseases (NCDs) remain major causes of mortality and disability globally. Up to 80% of cardiovascular events and up to 60% of NCDs are associated with potentially controlled risk factors (RFs). State-of-the-art digital technologies can help bridge the gap between evidence-based prevention methods and their critically low availability in routine clinical practice.
An innovative digital platform named PreventS-MD® is a specially developed tool for healthcare professionals to be used under time constraints. With PreventS-MD®, clinicians can estimate patient's 10-year cardiovascular risk within several minutes. Then, they automatically get adapted results and recommendations to address identified RFs as well as graphical representation of specific RF contribution to overall stroke and MI risks. If some additional time is available, the clinician and the patient can collaboratively set customized achievable goals to correct modifiable RFs. An integrated analytical module provides healthcare managers with current digital risk profiles of the relevant population to evaluate prevention effectiveness and to forecast the load throughout the healthcare levels.
PreventS-MD® has several unique advantages, including time-saving design, the function to activate motivated RF correction, individually tailored recommendations, and information on personally changed digital profiles of vascular risks. As cardiovascular diseases and main NCDs have a lot of common RFs, PreventS-MD® implemented into routine clinical practice will utilize a complex approach to the prevention of main NCDs, decreasing both stroke and MI burden and addressing complications of chronic pulmonary and kidney disease, tumors of any type, dementia, etc.
Opioid-Sparing Nonsteroid Anti-inflammatory Drugs Protocol in Patients Undergoing Intramedullary Nailing of Tibial Shaft Fractures: A Randomized Control Trial
Authors: Hess-Arcelay Hans , Claudio-Marcano Alexandra , Torres-Lugo Norberto J. , Deliz-Jimenez David , Acosta-Julbe Jose , Hernandez Gabriel , Deliz-Jimenez Daniel , Monge Gamaliel , Ramírez Norman , Lojo-Sojo Luis
Published: April 2024

Introduction:

Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective analgesics commonly used in fracture management. Although previously associated with delayed fracture healing, multiple studies have demonstrated their safety, with minimal risks of fracture healing. Given the current opioid crisis in the United States, alternate pain control modalities are essential to reduce opioid consumption. This study aims to determine whether the combination of oral acetaminophen and intravenous ketorolac is a viable alternative to opioid-based pain management in closed tibial shaft fractures treated with intramedullary nailing.

Methods:

We conducted a randomized controlled trial evaluating postoperative pain control and opioid consumption in patients with closed tibial shaft fractures who underwent intramedullary nailing. Patients were randomized into an NSAID-based pain control group (52 patients) and an opioid-based pain control group (44 patients). Visual analog scale (VAS) scores and morphine milligram equivalents (MMEs) were evaluated at 12-hour postoperative intervals during the first 48 hours after surgery. Nonunion and delayed healing rates were recorded for both groups.

Results:

A statistically significant decrease in MMEs was noted at every measured interval (12, 24, 36, and 48 hours) in the NSAID group compared with the opioid group (P-value 0.001, 0.001, 0.040, 0.024, respectively). No significant change in visual analog scale scores was observed at 12, 36, and 48 hours between both groups (P-value 0.215, 0.12, and 0.083, respectively). A significant decrease in VAS scores was observed at the 24-hour interval in the NSAID group compared with the opioid group (P-value 0.041). No significant differences in union rates were observed between groups (P-value 0.820).

Discussion:

Using an NSAID-based postoperative pain protocol led to a decrease in opioid consumption without affecting pain scores or union rates. Owing to the minimal risk of short-term NSAID use, their role in the perioperative management of tibia shaft fractures is justified, especially when they reduce opioid consumption markedly.

Level of evidence:

Therapeutic Level I.
An Analysis of Students’ and Teachers’ Needs of Microlearning-Based Learning Materials for English in Senior High School
Authors: Sugiarto Anrivere Muhammad Azka , Seli Fenny Yutika
Published: April 2024

The purpose of this research is to determine the students' requirements for microlearning-based English teaching materials for grade 12 senior high schools and to discover what the teacher demands on microlearning-based English teaching materials in senior high schools. This research goal was due to the COVID-19 pandemic that had a tremendous influence on Indonesian education, necessitating adaption and the use of technology. Various variables contributed to learning loss among 12th-grade students. Based on explanation above, the respondent of this research consists of 203 12th-grade students and 84 English teachers in Senior High School located mainly in West Jakarta.  A need analysis is required because adequate teaching materials are critical for effective English language acquisition. For first research instrument, writer use questionnaire with Likert Scale to ensure trustworthiness and data reliability and conducting interview for second research instrument. This research uses descriptive qualitative method to analyze the demands of students and teachers for microlearning-based learning materials in senior high school English, emphasizing the potential of microlearning for English language instruction. Providing concentrated information that can improve learning and fulfil the requirements of students, which also critical to improve English learning in Indonesia's 2013 curriculum
Profiling word retrieval abilities in persons with aphasia - A preliminary study
Authors: Channabasave Gowda Yashaswini , Nagaraj Hema
Published: April 2024

Various methods are used to elicit the naming responses. The current study aimed to assess different naming abilities in persons with aphasia. Naming abilities were assessed using varied types of naming tasks for PWA. PWA was subjected to eight types of naming tasks [Confrontation Naming (CN), Phonemic Fluency (PF), Semantic Fluency (SF), Serial Naming (SN), Ordinate Naming (ON), Automated Naming (AN), Responsive Naming (RN) and Sentence Completion (SC)] and compared with age, education matched neurotypical individuals (n=15). The assessment was carried out in the Kannada Language. The raw scores obtained for each task were tabulated and subjected to statistical analysis. On eight naming tasks, neurotypical individuals performed better than persons with post-stroke aphasia. Mann Whitney U test revealed a significant difference in the phonemic fluency task in both groups of participants with a value less than 0.05. Friedman analysis with adjusted Bonferroni showed a significant difference in pairwise comparison for eight naming tasks. Among which pairs with phonemic fluency task had a significant difference in both the groups (p< 0.05). The correlation between language impairment in PWA and types of naming was studied using WAB AQ scores with accuracy scores on different types of naming tasks. A significant correlation was seen between WAB AQ and the Phonemic fluency task. The nature of the task and the factors affecting the naming of each task influence the performance of the individuals. PWA has a difference in brain mechanism for naming compared to NTI. Phonemic fluency is recommended for regular naming assessments as it is simple, easy, and quick to administer. Also, it taps both the cognitive and linguistic abilities of an individual. Language impairment and different types of naming are well related in the current study. The need to assess all types of naming to understand the word production deficit is justified.
Injury Occurrence and Localization in Tennis: Perspectives on Prevention and Physiotherapy
Authors: Carboch Jan , Váchová Gabriela
Published: April 2024

Injuries happens in sports involving human movement, with the heightened demands of the sport often correlating with increased injury risk. Tennis, in particular, presents notable challenges as the repetitive motions involved can lead to muscle imbalances and varying levels of strain across different parts of the body. In this narrative literature review, we included 66 studies with the aim of providing a comprehensive overview of tennis-related injuries and offering insights into physiotherapy interventions for prevention and recovery. The first part of our review is on the most prevalent tennis injuries and their anatomical localization. It is noteworthy that injuries predominantly occur during matches rather than in training sessions. These injuries span a wide range, encompassing both acute and chronic conditions, affecting various parts of the body. Notably, muscle-tendon injuries are common, with frequent occurrences in areas such as the thigh, ankle, knee, and shoulder. Furthermore, it is observed that men suffer from back injuries compared to women. In the subsequent section, we delve into specific body regions and their associated injuries in greater detail. Our analysis leads to the recommendation that tennis players should engage with physiotherapists early in their sports careers for injury recovery and mainly for prevention measures. Collaboration with physiotherapists can significantly mitigate the risk of injuries and enhance overall performance and longevity in the sport.
Foliar Application of Sakurab (Allium Chinense G. Don) Extract on Tomato (Lycopersicon Esculentun) Production
Authors: Mautante S. K , Mala Sitty Aynah P
Published: April 2024

The demand for tomatoes is constantly high all year round. They are one of the most popular crops among home gardeners and farmers worldwide. Not only are they delicious, but they are also easy to grow and could provide high returns for the space they occupy. However, tomatoes are highly sensitive to several biotic and abiotic stresses. This study aimed to evaluate two varieties of tomatoes and their interaction effects in response to the application of Sakurab leaf extract as organic foliar fertilizer and insect pest repellent. It utilized Split Plot Randomized Complete Block Design (RCBD) replicated three times with 30 plots comprising two main plots: Tomato variety (V1 – Braveheart and V2 – Diamante). Each main plot was divided into five equal sub-plots: Sakurab leaf extract concentration [ F1 – control (no foliar application), F2 – 2% foliar fertilizer (20 ml/ L of water), F3 – 5% foliar fertilizer (50 ml/ L of water), F4 – 10% foliar fertilizer (100 ml/ L of water), and F5 – 15% (150 ml/ L of water) levels of concentrations. In terms of growth parameters, results revealed that the varying levels of Sakurab leaf extract foliar application did not significantly affect the plant height, days to first flowering, days to fruiting, and the days to harvest. However, the marketable fruits per tomato plot, marketable fruits per plant, and the marketable yield of tomato plants per hectare were significantly (P < 0.05) affected by varying levels of Sakurab foliar application. Based on the findings, the Diamante variety applied with a 15% (150 ml/L of water) level of Sakurab leaf extract concentration which produced the most marketable fruits per plot and the yield per ton/ha is recommended. Further experiment using a higher level of concentration of Sakurab leaf extract such as 30%, 60%, and 90% within a controlled environment, including the assessment of pest and disease incidence is proposed.
Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study
Authors: A Hemalatha , T Pradeep , G Vishnu , A Latha , K Vijaybabu
Published: April 2024

Background: Breast cancer (BC) has become the most common cancer among women in India. Both amlodipine, belonging to calcium channel blockers, and nebivolol, belonging to the beta blockers class have proven anticancer mechanisms. However, the effect has not been compared between these drugs till now.

Aim and Objectives: The present study aims to compare the antiproliferation effects of amlodipine and nebivolol against human breast adenocarcinoma MCF-7 cells.

Materials and Methods: Cell viability assay was used to screen the antiproliferation effects of the study drug molecules in MCF-7 cell cultures. The IC50 values were derived graphically by plotting the cell viability against drug concentration.

Results: Both amlodipine and nebivolol exhibited dose-dependent cytotoxicity against BC cells. The IC50 of amlodipine was 166.6 μg/mL and nebivolol was 114.6 μg/mL.

Conclusion: In this study, nebivolol showed potent cytotoxicity compared to amlodipine. This inference may provide further insights into future drug research.
Dietary Habits and their Impact on Physical Symptoms Severity in Young Females Diagnosed with PCOS
Authors: Sumaira Saeed
Published: April 2024

Polycystic Ovary Syndrome (PCOS) is characterized as chronic anovulation or oligo-menorrhoea and clinical hyper-androgenism. It involves excessive Gonadotrophin releasing hormone (GnRH) leading to over-production of luteinizing hormone (LH). Advanced glycation end products (AGEs) are formed as a result of consuming thermally processed and highly modified foods in body. AGEs are expressed as pro- inflammatory receptors and their production is exaggerated in women with PCOS. The purpose of this to check whether unhealthy dietary habitsresult in increased severity of physical symptoms of PCOS in diagnosed females. And to determine the importance of diet in dealing with PCOS. Cross-sectional study was conducted on a sample size of 45 participants (n=45) diagnosed with PCOS. For statistical analysis, SPSS was used and the values of Pearson’s Correlation Coefficient were used to identify the correlation between severity of symptoms and poor dietary habits. The results of our study ranged from weak to moderate which demonstrates that there is a correlation between severity of physical symptoms of PCOS and poor dietary habits. The results of the findings of this study stand true to the hypothesis that there is a correlation between severity of physical symptoms andpoor dietary habits.
Exploring policy trends and implications to support Singapore teachers’ AI and digital competencies
Authors:   Liberal Arts Innovation Center, Choi Ji Yeun , Kim Sang Cheol , Joo Young Hyeo , Kim Hee Kyu
Published: April 2024

The purpose of this study is to explore the value of Koryo Theart as a World Cultural Heritage Site by examining the value of Koryo Theart in Kazakhstan as a heritage and analyzing the suitability of listing it as a cultural heritage according to the World Heritage Evaluation Standards. To this end, the concept, type and the standards of world cultural heritage were confirmed. In addition, the cultural heritage of Kazakhstan, which has already been registered, and the criteria for its registration were confirmed. Next, in order to reveal the cultural value of Koryo Theart, the history of Koryo Theart, the relationship between Koryo Theart and Koryoin, and the role of Koryo Theart that continues to this day were examined. In addition, the World Heritage value of Koryo Theart was analyzed based on the criteria for listing cultural heritages similar to Koryo Theart. Considering the historical value of the suppression of minorities and the history of fairy tale policies, starting with the role of the Koryo Theart and the active migration policy, the Koryo Theart has cultural heritage value. The criterion for judgment is “bear a unique or at least exceptional testimony to a cultural tradition or to a civilization which is living or which has disappeared” and “be directly or tangibly associated with events or living traditions, with ideas, or with beliefs, with artistic and literary works of outstanding universal significance.”
A Study on the Awareness of Fire Safety Education in Unit Schools and Improvement Measures: Faculty and staff of Sejong City Office of Education
Authors:   Liberal Arts Innovation Center, Kim Chang Gil
Published: April 2024

This study analyzed the perception of fire safety education methods, satisfaction, consciousness, and behavior as the risk of fire increases due to the high-rise nature, complexity, and undergroundization of new schools and the aging of older school buildings. Based on the analysis, this study proposes improvement measures such as effective fire safety education methods, support measures, and curriculum organization. Differences in perception and needs between faculty and staff were first analyzed based on data of selfawareness of fire safety education conducted for school faculty and staff in the Sejong City Office of Education. As a result, remote training was the highest in the fire safety education method, and satisfaction was in the order of teachers, administrative staff, and educational assistants. In addition, the degree of change in fire safety awareness of faculty and staff was found in the order of teachers, administrative staff, and educational assistants. The degree of change in fire safety behavior was also in the order of teachers, administrative staff, and educational assistants, and an overall low awareness was found. By analyzing these needs, the following improvement measures are suggested. First, fire safety education should be conducted based on practice and experience from the perspective of an activist curriculum to enhance the ability to respond to actual incidents involving fire safety. Second, by linking fire safety education with the seven areas of school safety education, self-directed response ability can be enhanced from the perspective of a constructivist curriculum. Third, a plan is proposed to design and operate a fire safety curriculum by specializing in fire safety education according to the role of faculty members such as teachers and administrative staff.
Well-Aging Research Trends and Tasks
Authors:   Liberal Arts Innovation Center, Song Hyeon Dong , Kim Kwang Hwan , Kim Moon Joon , Park Arma
Published: April 2024

The purpose of this paper is to examine the current trends in research on well-aging and suggest new research directions. This is because Korea's entry into an aging society has raised fundamental questions about the meaning and value of life for individuals, and Koreans are faced with the challenges of solving problems such as poverty, loneliness, and illness in old age. To fulfill the research objectives, this paper reviews the existing wellaging research in academia. The existing well-aging research trends can be categorized into the concept of well-aging, curriculum and training needs, and program effectiveness and satisfaction. Future well-aging research tasks include policy research, interdisciplinary research, educational program development, spreading well-aging discourse in cooperation with civil society organizations, cultural movements, and wellness tourism. The results of this study are expected to provide an academic foundation for the formation of a well-aging culture that fits the Korean reality.
Image Separation and Sharing Application
Authors:   Assistant prof. Computer Science and Engineering Department. J.J Magdum College of Engineering, Jaysingpur, V Prof. Archana
Published: April 2024

A state-of-the-art project created as part of a program is the Image Separation and Sharing Application, which aims to transform the way A cutting-edge project developed as part of a program is the Image Separation and Sharing Application. The users interact with their image collections. Image separation and sharing Applications help users leverage facial recognition and machine learning techniques to build a smooth and effective image separation system. Key Words: image separation, image sharing, machine learning, user interface, Face net library, Face recognition
A Brief theoretical approach on Green Hydrogen Production
Authors:   Parul institute of Applied Science, Parul University, Modi Prabha
Published: April 2024

Many different technical techniques can be used to manufacture hydrogen from both renewable and nonrenewable feed supplies while reducing greenhouse gas emissions. Hydrogen is employed in upcoming low-carbon energy systems since it emits relatively little carbon. The bulk of the present green hydrogen activities are geared toward the possibility of a green hydrogen market. Green hydrogen and origin guarantees have been defined using various approaches. These vary according on the following: the carbon financial statements' characteristics; the emission threshold at which hydrogen is classified as green; the plan's feedstock and production techniques; and whether or not sustainable hydrogen must be produced through the use of renewable energy. To overcome obstacles and improve green hydrogen production's viability as a sustainable energy source, research is always moving forward. To hasten green hydrogen's integration into clean energy transitions and slow down global warming, research efforts are concentrated on increasing its efficiency, cutting prices, and broadening its applications. A study that focused on the near-zero carbon production method of green hydrogen by electrolysis using renewable energy sources underscored the advancements and prospects of this field of study. This article describes the current techniques for creating hydrogen from sustainable and renewable energy sources. Keywords: Green Hydrogen, Biomass, Efficiency, Renewable, Hydrogen production.
LAND DISPUTE SETTLEMENT REVIEW FROM MINANGKABAU TRADITIONAL LAW (CASE STUDY OF LIMAPULUH REGENCY, WEST SUMATRA PROVINCE CITY)
Authors: Nasir Muhammad
Published: April 2024

The purpose of this research is: (1) To understand the process of clearing estate lawsuit based on the customs of Minangkabau. (2) To understand the obstacles found during the case of clearing estate lawsuit based on the customs of Minangkabau. This research, utilizes empirist method in where law is socially, culturally, and das sein because in this research, the primary datas are collected from real cases. This research proves that; (1) The clearing process of heirloom lawsuit in Minangkabau is accomplished by the system of “Ladder up” and “Stairs down” starting from the neighborhood of clan, the neighborhood of tribe, and the neighborhood of Nagari. If the clearing process were not to reach an agreement, the clearing process shall be continued to the neighborhood of Nagari. (2) The obstacles that I find in the clearing process of heirloom lawsuit can be observed from two points of view. First, from the perspective of cultural leaders is the lack of willingness, the lack of economical resources, and the letter of bequest. Second, from the perspective of prosecutors is the element of time, the lack of agreement that can be mutually reached, and differences of opinion. Based on the data of my research, it is recommended that; (1) in order to avoid the obstacles mentioned by the researcher, the side of the prosecutors should require a person that can act as mediator (not a cultural leader) in order to prevent an event in which the tribal leaders from both side might clash. (2) For the government of West Sumatra to consider making local regulation regarding the inheritance of an estate with cultural value and allow the local regulation be spread in order to avoid further compication regarding estate lawsuit.
DIMENSION 6 BIM IMPLEMENTATION (SUSTAINABILITY & EFFICIENCY) IN THE PROCUREMENT PROCUREMENT CYCLE GOODS & SERVICES
Authors: Cornelis Arnoldus Jean
Published: April 2024

The application of the Building Information Model (BIM) method in a construction project, especially in Indonesia, can be counted as few who have implemented it in aligning the planning and implementation of a construction project activity, while if there is an application of the BIM concept, most of it is only as a formality only on the completeness of the Form document. of course, where the reality is that in practice there are many procedural deviations in creating an "Enviroment" of collaboration between work disciplines. In writing this paper, the problems will be analyzed: How is the process of implementing BIM in the 6D Dimension in the Supply Chain Cycle of the Procurement of Goods and Services problems. Writing based on this research has reference to knowledge base management, namely time management from references (eg PMBOK/Jurnal/BIM KEMENPUPR, etc.) and various relevant research results, literature review. This study uses the Fault Tree Analysis (FTA) method to answer the above problems. The results of this study are 1.. 2.. 3.. conclusions/research results. The analytical technique method that identifies system failures, the definition of failure is delay. The use of Top Down Analysis as a framework initially identifies and groups into Top Events in work delays, visualized into FTA graphics starting from Top Events to the most basic events.
“Free Text Is Essentially the Enemy of What We’re Trying to Achieve”: The Framing of a National Vision for Delivering Digital Police Contact
Authors: Wells Helen , Andrews Will , Clayton Estelle , Bradford Ben , Aston Elizabeth V. , O’Neill Megan
Published: April 2024

“Free Text Is Essentially the Enemy of What We’re Trying to Achieve”: The Framing of a National Vision for Delivering Digital Police Contact

Police organizations in England and Wales, as in many other contexts, are increasingly shifting crime reporting and other public-facing contact online. In this article, we explore the beliefs, motivations and objectives of those tasked with “delivering” the “vision” of digital police contact at the strategic national level. We use Goffman’s concept of frames – the set of expectations an actor brings to a situation or process – to understand how participants enacted this “channel shift” (Wells et al), the ends they were seeking to meet and how different interests came to be designed-in to the contact architecture. We suggest that the primary frame centred around notions of efficiency and demand management. Running alongside this is a secondary frame of customer service, where it is assumed that the public also wish for the efficient delivery of this technologically mediated service. This, we suggest, is likely to be only a partial reflection of what people want when contacting police; but the framing of “contact” as a separate deliverable by those delivering this agenda serves to occlude or evade this point. Technology, we argue, imprints itself on the context by appearing to offer a convenient solution to problems of public wants and police needs.
Iets over het gebruik van de term ‘wettelijk erfgenaam’ en de term ‘impliciete onterving’
Authors: Breemhaar W.
Published: April 2024

Iets over het gebruik van de term ‘wettelijk erfgenaam’ en de term ‘impliciete onterving’

In de column wordt het minder juiste gebruik van de termen ‘wettelijke erfdeel’ en ‘impliciete onterving’ besproken.
Bonuskleinkinderen: enkele civiele en successierechtelijke aspecten
Authors: Brinkman R.E.
Published: April 2024

Bonuskleinkinderen: enkele civiele en successierechtelijke aspecten

In dit artikel onderzoekt de auteur in welke civiel- en fiscaalrechtelijke relatie een zogenaamd ‘bonuskleinkind’ staat tot zijn ‘bonusgrootouders’. Aan de hand van een tekening wordt duidelijk gemaakt wat onder een bonuskleinkind moet worden verstaan.
The Effect of Earnings, Operating Cash Flows and Accruals in Predicting Future Operating Cash Flows
Authors: Rimet Rimet , Luthfiah Annisa
Published: April 2024

The purpose of this study was to analyse the effect of gross profit, operating profit, net profit, operating cash flow, changes in accounts receivable, changes in accounts payable, changes in inventory and depreciation expense simultaneously on the prediction of future operating cash flow. This research was conducted at food and beverage sub-sector companies listed on the Indonesia Stock Exchange (IDX) and registered from 2017 to 2019, totalling 32 companies. The sample in this study amounted to 17 companies using purposive sampling method. Data analysis using panel data regression with the help of Eviews. The results of the study explain that gross profit, operating profit, net income, changes and trade receivables have a significant effect, while operating cash flow, changes in debt, changes in inventory and depreciation expense do not have a significant effect on the prediction of future operating cash flow in food and beverage sub-sector companies listed on the Indonesia Stock Exchange (IDX) for the 2017-2019 period. Simultaneously gross profit, operating profit, net profit, operating cash flow, changes in accounts receivable, changes in accounts payable, changes in inventory and depreciation expense have an influence on the prediction of future operating cash flows in food and beverage sub-sector companies listed on the Indonesia Stock Exchange (IDX) for the 2017-2019 period.