bluuebunny/crossref_metadata_2025 huggingface dataset:
General Principles of Good Governance in Indonesia: What are The Legal Bases?
Authors: Zamroni M.
Published: September 2019

The concept of a welfare state starts from many typical countries, namely the Police State (Polizei Staat), the State of Formal Law (Liberal) and the State of Material Law (Welvaarstaat / welfare state). The Police State and the Welfare State are considered as extreme forms of legal state because the State Police is the beginning of the Law State. Welfare State is a type of legal state that is considered current. The Principles of Good Governance were born during the development of the Welfare State. This study reveals the legal basis of the General Principles of Good Governance of several regulations. The results show that the general principle of good governance is currently regulated comprehensively in regulation in Indonesia. The regulation includes 1) Act Number 28 of 1999 on State Implementation of the Clean and Free from Corruption, Collusion and Nepotism 2) Act Number 9 of 2004, concerning the Amendment to Indonesian Act Number 5 of 1986 on Administrative Courts Country 3) Act Number 25 of 2009 on Public Service 4) Act Number 30 of 2014 concerning Government Administration. As a modern country, general principles of good governance is the spirit for the implementation of the government administration of the Indonesian Republic, especially in the context of the implementation of clean governance based on expediency, justice, and legal certainty.
Lymphomas and Kaposi’s Sarcoma in South Ethiopia: results from a cancer registry 1963 – 1986
Authors: Lindtjorn Bernt
Published: September 2019

The pattern of Non-Hodgkin's lymphoma and aggressive Kaposi's sarcoma is known to have changed in some countries as the prevalence of the acquired immunodeficiency syndrome increases. A retrospective analysis of histologically verified cancers in southern Ethiopia during the period 1963-86 did not demonstrate any change in the pattern of aggressive Kaposi's sarcoma nor of Non-Hodgkin lymphomas, suggesting that the HIV epidemic did not start before the mid-1980s.
ANALISIS SISTEM PEMBIAYAAN PADA PERBANKAN SYARIAH
Authors: Ilyas Rahmat
Published: September 2019

Sistem keuangan dan perbankan Islam merupakan bagian dari konsep yang lebih luas tentang ekonomi Islam, dimana tujuannya adalah memberlakukan sistem nilai dan etika Islam ke dalam lingkungan ekonomi.Larangan riba dalam Islam, sebagaimana juga dalam beberapa agama lain, dan inspirasi umat Islam untuk menerapkan larangan ini dalam kehidupan ekonomi telah merangsang terbentuknya sejumlah lembaga keuangan syariah diseluruh penjuru dunia dalam tiga dekade terakhir.Diantara lembaga tersebut adalah bank komersial dan investasi, perusahaan asuransi (takaful), perusahaan leasing dan mudharabah serta lembaga non lainnya.Lembaga keuangan merupakan lembaga yang mempertemukan antara pihak yangmempunyaikelebihandana(surplus of funds)denganpihakyang mengalami kekurangan dana (lack of funds). pentingnya lembaga keuangan sebagai salah Satupilar ekonomi dapat dilihat dari berbagai kebijakan pengucuran dana pinjaman usaha berbagai usaha.
ANALISIS IMPLEMENTASI AKAD MURABAHAH DAN FATWA ULAMA TERHADAP PERKEMBANGAN PERBANKAN SYARIAH DI INDONESIA
Authors: Anwar Amelia , PERKASA MAKI HUD LEO
Published: September 2019

Penelitian ini bertujuan untuk menganalisis implementasi akad murabahah dan fatwa ulama terhadap perkembangan perbankan syariah di Indonesia. Pesatnya perkembangan perbankan syariah di Indonesia yang harus diimbangi dengan kejelasan tentang konsep murabahah. penelitian ini merupakan penelitian kualitatif dengan menggunakan metode studi kasus tipe eksplanatoris. Studi ini menggambarkan fenomena Objek penelitian, dalam hal ini adalah akad murabahah dan fatwa ulama di dalam perkembangan perbankan syariah di Indonesia. Data diperoleh melalui wawancara tehnik, observasi partisipan, dan dokumentasi. Berdasarkan hasil penelitian menyimpulkan bahwa dalam penerapan akad  murabahah di perbankan syariah terdapat 3 ( tiga) tipe pembiayaan serta ada beberapa aspek yang telah disesuaikan perusahaan dengan peraturan hukum. Aspek itu adalah besarnya keuntungan yang diperoleh perbankan syariah disesuaikan dengan tipe pembiayaan serta diatur dalam otoritas jasa keuangan, undang-undang, fatwa DSN MUI.
TANTANGAN PENDIDIKAN ISLAM DAN BUDAYA LOKAL PADA ERA GLOBALISASI DI INDONESIA
Authors: Kurniawan Akhmad Syarief
Published: September 2019

One of the major problems faced by Indonesia (and other nations) is related to the process (transformation) from an agrarian society to an industrial society and information, which is characterized by a variety of physical changes, social institutions as well as a shift in the value system. These changes are accompanied also a clash between traditional values ​​inherent in the agrarian culture with cultural values ​​and culture industry information. Education is essentially an attempt to pass a value, which will be a helper and guide mankind in life, and also to improve the fate of human civilization. Globalization delivered by modernization and globalization and rooted in Western culture has indeed been giving a lot of achievements for the nations in various fields of life. Education, agriculture, medicine, communications, entertainment and physical infrastructure greatly benefited by the presence of modernization and globalization.
KREATIVITAS BERFIKIR, TEKNIK PENULISAN DAN PENGUASAAN METODOLOGI PENELITIAN: Analisis Terhadap Kualitas Skripsi Mahasiswa STAIN Jurai Siwo Metro
Authors: Kuryani Kuryani
Published: September 2019

Undergraduate Thesis (Skripsi) is one of the scientific writing that should be written by the students before finishing their study at a university. It is also called scientific wrtting because it shoul be written logically, systematically and originally. For good scientific writing, the students need to the thinking creativity, writing technique, and research methodology mastery.The aim of this research is know the quality of undergraduate thesis written by the students of State Islamic College (STAIN) Jurai Siwo Metro in the period of 2010-2015. This research had been conducted in STAIN Jurai Siwo Metro Library by observing and anlysing the tudents’ undergraduate thesis that written in those periods. Based on the finding of research can be identified that the quality of students undergraduate thesis still in low level. The low quality of students’ undergraduate thesis caused by 69,60% of students had lack of thinking creativity, 64,61% of students could not write perfectly in writing technique, and 64,57% of students didn’t master the research methodology. This low quality was not only made by the students. But also there were many factors that can influence the case. The lecuters and the sponsors were also had strategis role in their writing. But more over the students should be studying hard to be able and master thinking creavity, writing technique dan research methodology.
MENGENAL PENDIDIKAN KEIMANAN DALAM AL-QURAN
Authors: Hoktaviandri Hoktaviandri
Published: September 2019

Man was created by Allah SWT as a peadagogical creature in the sense of having the potential to be educated and educated. In principle the goal of man is created is to worship him. Anything done just wishes Allah SWT. For worship that is done in accordance with his expected then the deed should be based on faith. The potential of faith has existed from the time humans were born. Therefore, faith needs to be continually nurtured through education.
ISLAM DAN KESETARAAN PEREMPUAN DALAM PENDIDIKAN
Authors: Zumaro Ahmad
Published: September 2019

Education is a human right for every individual and must be given without distinguish of sex. Therefore, education must be reached everyone without distinguish of sexs. But in practice, there are still among the moslems bound the women to get education. This is due to failure in understanding of  women obligation to study. The mistaken in understanding text  in the Al-Quran or hadith will cause errors in its application and can cause do harm to women
PENGETAHUAN INVESTASI, MOTIVASI INVESTASI, LITERASI KEUANGAN DAN LINGKUNGAN KELUARGA PENGARUHNYA TERHADAP MINAT INVESTASI DI PASAR MODAL
Authors: Darmawan Akhmad , Kurnia Kesih , Rejeki Sri
Published: September 2019

This study aims to analyze the effect of investment knowledge, investment motivation, financial literacy and family environment on the interest in investing in the capital market. This type of research is quantitative. The population of this study were students of the Management Study Program of the Faculty of Economics and Business, Muhammadiyah Purwokerto University in the year 2016 and 2017 with the sample criteria of active students of FEB UMP and those who were / had taken financial management and entrepreneurship courses. Data collection in this study using the questionnaire method. Instrument testing was analyzed using validity test and reliability test. Data analysis techniques used in this study are classic assumptions and multiple linear regression analysis.

             The results showed that: (1) investment knowledge, investment motivation, and financial literacy simultaneously had a significant effect on investment interest. (2) investment knowledge partially does not affect investment interest. (3) investment motivation partially has a significant effect on investment interest. (4) financial literacy partially has a significant effect on investment interest. (5) the family environment partially has a significant effect on investment interest.

keywords: Knowledge, Motivation, Literacy, Environment, Interests.
PENGARUH KINERJA KEUANGAN TERHADAP NILAI PERUSAHAAN YANG DIMEDIASI OLEH PENGUNGKAPAN SUSTAINABILITY REPORT
Authors: Widhiastuti Susanti , Eftianto Eftianto , Ahmadi Slamet
Published: September 2019

This study aims to determine the effect of financial performance, on the value of the company with disclosure of sustainability report as a mediating variable. The population in this study are companies listed on the Indonesia Stock Exchange and consistently included in the SRI-KEHATI Index from 2012-2016 as many as 19 companies. The selection of samples using purposive sampling method and the sample used in this study amounted to 14 companies for 5 years. The method of analysis uses multiple regression.

The results showed that profitability and liquidity as a measure of the company's financial performance did not affect the disclosure of sustainability bother while the solvency had an effect on disclosure of sustainability bother. Profitability and solvency affect the value of the company, but liquidity and sustainability report disclosure do not affect the value of the company. This study also shows that sustainability report disclosure cannot mediate the effect of financial performance on firm value.

Keywords: Financial Performance, Sustainability Report, Company Value
Assessment of Some Physico-Chemical Parameters of Lagos Lagoon, Southwestern Nigeria
Authors: Olaoye Oyeleke Peter , Olatunde Popoola Samuel , Ayoola Abiodun Olushola
Published: September 2019

The pollution status of Lagos Lagoon was investigated to determine some physical and chemical parameters, in order to further understand its water quality. Five locations were selected according to the anthropogenic activities taking place in the areas. The measured parameters are water temperature, salinity, conductivity, pH, dissolved oxygen (DO) and alkalinity. The mean values ranged from 28.50-30.15°C for temperature, 7.86-8.50 for pH, ND-10.60‰ for salinity, 0.18-15.20µS/cm for electrical conductivity, 12.00-14.00 mg/l for alkalinity and 1.60-6.40 mg/l for dissolved oxygen. The statistical analysis of the measured physicochemical parameters revealed non-significant difference (p>0.05) across all stations in the physico-chemical parameters. Generally, the values obtained suggest the influence of anthropogenic activities especially the depletion of DO in most of the stations. Therefore, point source and non-point source pollution into the Lagos Lagoon should be controlled for the health and safety of the aquatic ecosystems. Generally, all the measured parameters were either below or within the permissible limits obtainable in the marine environment.
The Success Factors of and Barriers Faced by Entrepreneurial SMEs in Jordon
Authors: Alhorani Alaa
Published: September 2019

The research study aims to investigate the existing barriers and success factor related to entrepreneurial SMEs in Jordan. This study adopts a quantitative methodology to examine the research problem and pursues a descriptive design, which involves a survey. The sample size of the study is 54 SMEs entrepreneurs or their representatives, based in Jordan. The results from the same indicated that product quality, cash sufficiency and effective business location plays an important role in the success of entrepreneurial SMEs in Jordan. Some of the major barriers identified by the respondents are lack of technological advancement, high cost of financing and lack of effective training for employees of the business. Lastly, the conclusion has been presented with three crucially important recommendations for such SMEs.
Effect of Reactive Agility Training Drills on Speed and Agility in Indonesian University Students
Authors: W. Kusnanik Nining , Widiyanto Wahyu E. , P. Bird Stephen
Published: September 2019

The purpose of this research was to determine the potential training effect of reactive agility in improving speed and agility. This study was conducted on 36 students and divided into 3 groups with 12 students per groups. Group 1 was given lateral mirror drill, Group 2 sprint mirror drill, and Group 3 conventional training for a period of 8 weeks, 3 times/week with a day off. Performance measures of agility and speed were assessed via the T-test for agility and 30m sprints for speed, respectively. Data was analyzed using paired sample t-test and multivariate analysis of variance. The result of this study found that there was a significant effect of sprint mirror drill to improve speed and agility; there was a significant effect of lateral mirror drill in improving speed and agility; there was a difference effect of lateral mirror drill and sprint mirror drills in improving speed and agility. Conclusion: these data provide preliminary support of incorporating reactive agility drills such as the sprint mirror and lateral mirror drills in improving performance measures of speed and agility.
Karakterisasi Karakter Fisiologi Genotipe-Genotipe F2 Padi Ketan dengan Kemampuan Recovery Setelah Infeksi Tungro
Authors: Komalasari Ema , Widiantini Fitri , Sari Santika , Carsono Nono
Published: September 2019

Penyakit pada padi, salah satunya tungro masih menjadi pembatas utama produksi padi di Indonesia. Pengendalian efektif dapat dilakukan melalui penggunaan dan pergiliran varietas tahan. Tujuan penelitian ini untuk mengetahui fisiologi genotipe-genotipe yang mengalami recovery setelah serangan tungro dibandingkan dengan genotipe-genotipe tahan. Penelitian dilakukan pada dua populasi generasi kedua persilangan Ketonggo x Utri Merah dan Ketonggo x ARC12596 masing-masing 230 genotipe di rumah kaca BB Padi dan Kebun percobaan Universitas Padjadjaran. Inokulasi virus pada tanaman dilakukan dengan menggunakan forced-tube inoculation dan skoring gejala berdasarkan sistem evaluasi standar untuk padi. Pengamatan kandungan klorofil, jumlah konduktansi stomata, dan kuantum efisiensi fotosintesis dilakukan dengan membandingkan antara grup genotipe recovery dengan grup genotipe tahan dan grup genotipe rentan, serta varietas cek tahan, dan varietas cek rentan. Hasil penelitian menunjukkan bahwa secara umum genotipe-genotipe recovery dari persilangan Ketonggo x Utri Merah tidak memperlihatkan perbedaan yang signifikan dengan genotipe tahan maupun cek tahan pada pengamatan kandungan klorofil, konduktansi stomata, dan kuantum efisiensi fotosintesis. Hasil yang sama juga diperoleh untuk persilangan Ketonggo x ARC12596. Genotipe-genotipe yang mengalami recovery dari kedua persilangan memiliki morfologi dan fisiologi yang sama baiknya dengan genotipe tahan dan cek tahan sehingga dapat digunakan untuk menekan penyebaran penyakit tungro.
REVIEW ARTICLE: DEVELOPEMENT AND USING DENGUE VACCINE FOR DENGUE INFECTION VIRUS
Authors: Massey Firdaus Kabiru , Yulia Rika
Published: September 2019

Abstract : Tropical and subtropical countries are regions with high incidence of dengue infection. Dengue virus infection is estimated to cause 300 million new infections in one year and approximately 1 million severe cases with 2 + 5% deaths. The case of dengue in Indonesia has continued to increase since 1968 until 1980 where all provinces in Indonesia have been affected by the dengue virus. Dengue virus is a virus carried by the Aedes aegypti mosquito in its salivary gland. The virus which is a family group of Flaviviruses has four homologous serotypes, namely DENV-1, DENV-2, DENV-3, and DENV-4, which can cause dengue infection in individuals. Currently there is a shift in the target population from children to adults. This is a problem that needs to be resolved by the government and the community itself. Solution to overcome this, the government needs early prevention efforts to reduce the severity of dengue infection by developing and researching dengue vaccines. Currently a vaccine has been found that can be used as prophylaxis for dengue virus, namely Dengvaxia. This vaccine has been recommended by the World Health Organization (WHO) as prophylaxis for dengue infection, but Dengvaxia is only used in areas that are very endemic to dengue fever. The Indonesian Food and Drug Supervisory Agency (BPOM RI) has also approved the use of Dengvaxia as an indication of prevention of dengue infection since August 31, 2016. This vaccine has been approved globally only given to individuals aged between 9-16 years. 

Keyword : dengue virus, dengvaxia vaccine, Aedes aegypti, endemic
CHITOSAN AS ANTIFUNGAL IN CHANNA STRIATA COLLAGENCHITOSAN FOR WOUND HEALING
Authors: Andini Ary , Prayekti Endah
Published: September 2019

The Snakehead fish contains high protein that was mostly used as a treatment during healing process in either invasive or passive surgery. Therefore, it could be developed as well as a mixture of wounds dressing for skin healing. The aim of this study was to know the effect of  combination of concentrations between chitosan and collagen of  Snakehead fish  (Channa striata) skin and scales on fungal total number recovered from the composite. Snakehead fish skin and scales was treated by soaking in 2% HCl solvent for 48 hours to obtain collagen from its filtrate. Filtrate obtained continued to neutralize with 1 M NaOH until soluble collagen  appeared. Collagen obtained in this study then  mixed with 2% chitosan liquid to make wound dressing in various concentrations group. Combination of colagen mixture in this study were chitosan liquid only as control, 25% collagen-75% chitosan (C1), 50% collagen-50% chitosan (C2) and 75% collagen-25% chitosan (C3). The study results showed that on Control, C1 and C2 group there was no fungal contamination, but on C3 group there was contamination of fungal with total counting about 2,43 x 103 CFU. Based on statistically test showed that there was discrepancy for each group with p-value was 0,02 (p<0,05).
KONFIRMASI LIMA FAKTOR YANG MEMPENGARUHI KEPUASAN PESERTA PEKERJA BUKAN PENERIMA UPAH (PBPU) BPJS KESEHATAN
Authors: Nuraeni Maya Fitri
Published: September 2019

Kepuasan pelanggan merupakan suatu pemenuhan harapan pelanggan yang dirasakan sesuai dengan ekspektasi yang diharapkan. Tujuan penelitian Mengetahui pengaruh langsung dan tidak langsung serta besaranya antara faktor Customer Relation Management (CRM), Customer Engagement, Kualitas Layanan, Trust dan Costumer value  Terhadap Kepuasan Peserta PBPU BPJS Kesehatan KC Depok Tahun 2018. Desain penelitian cross sectional. Populasi penelitian keseluruhan peserta di BPJS Kesehatan KC Depok. jumlah sampel dalam penelitian ini adalah smpel 130 peserta PBPU yang berkunjung ke KC Depok. Metode analisis menggunakan SmartPLS 2.0 dan SPSS 16. Hasil penelitian menunjukkan variabel CRM  24,58%, Customer Engagement 19,50 %. Kualitas Layanan 11,93%, Trust 14,36%,Costumer value 6,13%. pengaruh langsung CRM terhadap Customer Engagement 49,96%, CRM terhadap kualitas layanan 66,42%, CRM terhadap Trust 4,38%, CRM terhadap customer value 30,80%, Customer Engagement terhadap kualitas layanan 4,58% Customer Engagement terhadap Trust 15,21%, Customer Engagement terhadap customer value 16,77 Kualitas Layanan terhadap Trust 30,66%, Kualitas Layanan terhadap customer value 11,01%, Trust terhadap customer value 14,54%. Dengan demikian dapat ditarik kesimpulan bahwa  paling mempengaruhi Kepuasan Peserta PBPU BPJS Kesehatan KC Depok, dikarenakan CRM merupakan keseluruhan proses membangun dan memelihara hubungan peserta khususnya PBPU dengan BPJS kesehatan yang akan meminimalisir penurunan kualiatas pelayanan sehingga dapat meningkatkan pelayanan yang lebih baik. BPJS Kesehatan KC Depok diharapkan dapat memberikan pelayanan terbaik bagi npeserta sesuai dengan nilai dasar untuk tercapainya kepuasan pelanggan.
Minimax Estimation of the Scale Parameter of Laplace Distribution under Modified Linear Exponential (MLINEX) Loss Function
Authors: Hasan M. R.
Published: September 2019

The main objective of this paper is to find the minimax estimator of the scale parameter of Laplace distribution under MLINEX loss function by applying the theorem of Lehmann (1950). The estimator is then compared with classical estimator like moment estimator with respect to mean square errors (MSEs) through R- Code simulation. The result has shown that the minimax estimator under MLINEX loss function is better than moment estimator for all sample sizes. Finally, mean square errors of different estimators corresponding to sample size are presented graphically.
Lessons from The History of Medical Science
Authors: Moniruddin ABM
Published: September 2019

Abstract not available.

KYAMC Journal Vol. 10, No.-2, July 2019, Page 64-65
Management of Fractures Shaft of Tibia in Adult Interlocking Nailing Versus Plating in: A Comparative Study
Authors: Islam Md Ashraful , Rashid Md Abdur , Islam Md Rafiqul , Milon Md Hafizur Rahman , Mahmud Md Kaiser
Published: September 2019

Background: Tibial shaft fractures are the commonest long bone fractures in adults, most commonly managed by intramedullary interlocking nailing. However, several meta-analysis show that locking plate osteosynthesis is equally effective in managing tibial diaphyseal fractures and are associated with less number of complications.

Aim: To compare the results of fixation of tibial fractures followingplating and nailing in terms of union, patient satisfaction and complications.

Materials and Methods: Khwaja Yunus Ali Medical College and Hospital based non randomized clinical trial was performed from September 2014 to August 2017 where closed or open diaphyseal or metaphyseo- diaphyseal fractures of the tibia (closed or open Gustilo Anderson type 1 through 3B) were included. Simple sequential allocation was used for allotting the patients to two groups, one for interlocking nailing and other for plating. The patients were followed up for clinical, radiographic and functional results.

Results: Forty patients with 41 involved limbs completed followup for one year. in our study was 19.55±0.69 weeks in case of interlocking nailing and 20.38±1.39 weeks in case of plating and there was no statistically significant difference between the two.

Conclusion: There was no difference between the twomodalities in terms of fracture union. Complications were lesser but more serious in case of plating. Patient satisfaction was more with plating.

KYAMC Journal Vol. 10, No.-2, July 2019, Page 99-105
A Clinical Profile and Co-morbidities of Pemphigus Vulgaris Patients: A Study of 35 Cases
Authors: Razzaque Md Abdur , Ali Zulfikar , Uddin Kazi Shihab , Islam Md Imtiajul , Nath Sajib Kumar
Published: September 2019

Background: Pemphigus vulgaris (PV), an autoimmune blistering disease involving the skin and mucosa. PV frequently begins with oral lesions and progresses to skin lesions. Autoimmune bullous skin disorders are associated with IgG or IgA auto- antibodies against distinct adhesion molecules of the epidermis and dermal epidermal basement membrane zone, respectively. These auto- antibodies lead to a loss of skin adhesion which shows up clinically as the formation of blisters or erosions.

Objectives: To characterize the clinical parameters and co-morbidities of PV patients from a single tertiary medical centre in Bangladesh.

Material and Methods: This observational study was done including 35 PV patients attending in the department of Dermatology and Venereology, Khwaja Yunus Ali Medical College Khawja Eunus Ali Medical College from 2010 to 2014. Thirty patients of pemphigus diagnosed clinically confirmed and treated over a 4-year period (2010-2014).

Results: Majority of the patients 45.7% belongs to age group 41-50 years. Mean age 47.12±11.13. The male to female ratio in our study sample was 1:1.5. The youngest patient was 17 years old and the oldest 68. For both genders, the risk of onset peaked during the fifth and sixth decade of life. Out of 35 patients, 15(42.9%) was presented with mucosal lesions only, while 13 patients 37.1% had mucocutaneous lesions and 7 patients 20% had only cutaneous lesions. The most common comorbidies were hypertension 20.0%, osteoporosis 17.1%, and diabetes 8.6%, thyroid disease 8.6%, psoriasis 5.7%, rheumatoid arthritis 2.7%, rheumatic fever 2.9%, autoimmune hepatitis 2.9%, and myasthenia gravis 2.9%.

Conclusion: The associated comorbidities of PV emphasize the need for dermatologists to keep a high index of suspicion and actively evaluate patients to determine their presence.

KYAMC Journal Vol. 10, No.-2, July 2019, Page 106-109
Routine Measurements of Cardiac Parasympathetic and Sympathetic Nervous Systems Assists in Primary and Secondary Risk Stratification and Management of Cardiovascular Clinic Patients
Authors: Murray Gary L , Colombo Joseph
Published: September 2019

Objective: To review our studies of the ease and importance of Parasympathetic and Sympathetic (P&S) measures in managing cardiovascular patients.
Background: The autonomic nervous system is responsible for the development or progression of Hypertension (HTN), orthostasis, Coronary Disease (CAD), Congestive Heart Failure (CHF) and arrhythmias. Finally, new technology provides us with rapid, accurate P and S measures critically needed to manage these patients much more successfully.
Methods: Using the ANX 3.0 autonomic monitor, P&S activity was recorded in 4 studies: 163 heart failure patients in total, mean follow-up (f/u) 12-24.5 months; 109 orthostasis patients, f/u 2.28 years and 483 patients with risk factors or known HTN, CAD or CHF, f/u 4.92 yrs. All were on guideline-driven therapy.
Results: 59% of CHF patients had dangerously high Sympathovagal Balance (SB) or Cardiac Autonomic Neuropathy (CAN) and Ranolazine markedly improved 90% of these, improved left ventricular ejection fraction in 70% of patients on average 11.3 units, and reduced Major Adverse Cardiac Event (MACE) [Acute Coronary Syndromes (ACS), death, acute CHF, Ventricular Tachycardia/Ventricular Fibrillation (VT/VF)] 40%. 66% of orthostatic patients corrected with (r) Alpha Lipoic Acid ([r]ALA); non-responders had the lowest S-tone. In the 483 patient study, SB>2.5 best predicted MACE when compared to nuclear stress and echocardiography (sensitivity 0.59 or 7.03 [CI (Confidence Interval) 4.59-10.78], specificity 0.83, positive predictive value 0.64 and negative predictive value 0.80).
Conclusion: Parasympathetic and sympathetic measures significantly improve care of cardiovascular patients.
The Proscenium of Opera Houses as a Disappeared Intangible Heritage: A Virtual Reconstruction of the 1840s Original Design of the Alighieri Theatre in Ravenna
Authors: D’Orazio Dario , Rovigatti Anna , Garai Massimo
Published: September 2019

In a Historical Opera House (HOH), the proscenium is the foreground part of the stage. Until the end of the 19th Century, it was extended through the cavea, being the orchestra placed at the same level of the stalls, without an orchestra pit. Soloists often moved in the proscenium when they sung, in order to increase the strength of the voice and the intelligibility of the text. The Alighieri theatre in Ravenna, designed by the Meduna brothers, the former designers of Venice’s “La Fenice” theater, is chosen as a case study. During a refurbishment in 1928, the proscenium of the stage was removed in order to open the orchestra pit, which was not considered in the original design. The original design and the present one are compared by using numerical simulations. Acoustic measurements of the opera house and vibro-acoustic measurements on a wooden stage help to reach a proper calibration of both models. Results are discussed by means of ISO 3382 criteria: the proscenium increases the sound strength of the soloists but reduces the intelligibility of the text.
Challenges for Management in Implementing Reforms at the Ministry Level and in Health and Social Service Organizations in Finland
Authors: Niiranen Vuokko , Zitting Joakim , Laulainen Sanna
Published: September 2019

The Finnish health and social care sector is currently undergoing numerous reforms. These reforms involve novel demands regarding the role of steering, decision-making, and management in health and social services. This article sheds light on some of the critical factors encountered by decision-makers and managers when implementing reforms to change health and social services. The article investigates cooperation between the steering ministries and different dimensions of management in local health and social service organizations. Interview data from the ministries were studied through content analysis, and quantitative survey data were analyzed using mean values guided by the model of multidimensional management. The co-operation between different ministries has intensified while implementing different reforms, but functional and cultural boundaries between them persist. The management dimensions in changing health and social service organizations stress the role of managers as facilitators and enablers, highlighting the significance of caring for the human resource dimension as one of the managers’ core tasks. The successful implementation of change should never be automatic. What emerges prominently is the skill essential to achieve cooperation which transcends the borders of both multiprofessional and traditional professional and administrative work both in ministries and local health and social service organizations.
Mirrors Can Affect Growth Rate, Blood Profile, Carcass and Meat Traits and Caecal Microbial Activity of Rabbits Reared in a “Small Group” Free-Range System
Authors: Musco Nadia , Lombardi Pietro , Addeo Nicola Francesco , Secci Giulia , Parisi Giuliana , Pero Maria Elena , Piccolo Giovanni , Nizza Antonino , Bovera Fulvia
Published: September 2019

The aim of this work was to propose a model of free-range raising for rabbit able to maximize the animal welfare and at the same time the productive performances through the use of mirrors. A total of 81 rabbits were allocated into free-range areas and divided into three groups (nine replicates per group): in the first group (face to face, F2F), the rabbits of each replicate could see each other. In the second group (blind) each replicate was isolated from the others; in the third group (mirrors), the replicates were divided as for the Blind group but two mirrors were placed in a corner of the perimeter. The blind group rabbits showed the lowest final weight (p < 0.05), while rabbits from the mirrors groups showed the best FCR and net dressing out values. The blind group showed the highest production of total short chain fatty acids, acetate (p < 0.05) and propionate (p < 0.01). The F2F rabbits showed higher levels of creatine phosphokinase and lactate dehydrogenase and lower values of blood glucose than those of the other groups, due to the higher locomotion activity. The use of mirrors can improve rabbit’s growth performance and carcass traits by lowering the rabbit’s locomotion activity in comparison to the other tested systems.
Prediction of Mineral Composition in Commercial Extruded Dry Dog Food by Near-Infrared Reflectance Spectroscopy
Authors: Goi Arianna , Manuelian Carmen L. , Currò Sarah , De Marchi Massimo
Published: September 2019

The pet food industry is interested in performing fast analyses to control the nutritional quality of their products. This study assessed the feasibility of near-infrared spectroscopy to predict mineral content in extruded dry dog food. Mineral content in commercial dry dog food samples (n = 119) was quantified by inductively coupled plasma optical emission spectrometry and reflectance spectra (850–2500 nm) captured with FOSS NIRS DS2500 spectrometer. Calibration models were built using modified partial least square regression and leave-one-out cross-validation. The best prediction models were obtained for S (coefficient of determination; R2 = 0.89), K (R2 = 0.85), and Li (R2 = 0.74), followed by P, B, and Sr (R2 = 0.72 each). Only prediction models for S and K were adequate for screening purposes. This study supports that minerals are difficult to determine with NIRS if they are not associated with organic molecules.
How Does Pyridoxamine Inhibit the Formation of Advanced Glycation End Products? The Role of Its Primary Antioxidant Activity
Authors: Ramis Rafael , Ortega-Castro Joaquín , Caballero Carmen , Casasnovas Rodrigo , Cerrillo Antonia , Vilanova Bartolomé , Adrover Miquel , Frau Juan
Published: September 2019

Pyridoxamine, one of the natural forms of vitamin B6, is known to be an effective inhibitor of the formation of advanced glycation end products (AGEs), which are closely related to various human diseases. Pyridoxamine forms stable complexes with metal ions that catalyze the oxidative reactions taking place in the advanced stages of the protein glycation cascade. It also reacts with reactive carbonyl compounds generated as byproducts of protein glycation, thereby preventing further protein damage. We applied Density Functional Theory to study the primary antioxidant activity of pyridoxamine towards three oxygen-centered radicals (•OOH, •OOCH3 and •OCH3) to find out whether this activity may also play a crucial role in the context of protein glycation inhibition. Our results show that, at physiological pH, pyridoxamine can trap the •OCH3 radical, in both aqueous and lipidic media, with rate constants in the diffusion limit (>1.0 × 108 M − 1 s − 1 ). The quickest pathways involve the transfer of the hydrogen atoms from the protonated pyridine nitrogen, the protonated amino group or the phenolic group. Its reactivity towards •OOH and •OOCH3 is smaller, but pyridoxamine can still scavenge them with moderate rate constants in aqueous media. Since reactive oxygen species are also involved in the formation of AGEs, these results highlight that the antioxidant capacity of pyridoxamine is also relevant to explain its inhibitory role on the glycation process.
The Methanol Extract of Allium cepa L. Protects Inflammatory Markers in LPS-Induced BV-2 Microglial Cells and Upregulates the Antiapoptotic Gene and Antioxidant Enzymes in N27-A Cells
Authors: Jakaria Md. , Azam Shofiul , Cho Duk-Yeon , Haque Md. Ezazul , Kim In-Su , Choi Dong-Kug
Published: September 2019

Neuroinflammation, apoptosis, and oxidative stress are connected to the pathogenesis of neurodegenerative diseases (NDDs). Targeting these three factors, the intervention of neuroprotective agents may have great potential in the treatment of NDDs. In the current study, the anti-inflammatory effects of the methanol extract of Allium cepa (MEAC) in lipopolysaccharide (LPS)-induced BV-2 microglial cells were investigated. MEAC has been studied in regard to the regulation of the antiapoptotic gene (Bcl-2) and various antioxidant enzyme (HO-1, NQO-1, and catalase) expressions in N27-A cells. Additionally, the protective action of MEAC has also been studied against MPP+-induced death in N27-A cells. The results suggest that MEAC is significantly protected from NO release and increase iNOS expression at the mRNA and protein levels in LPS-stimulated BV-2 microglial cells. MEAC treatment also protects COX-2 expression at the mRNA and protein levels. Furthermore, MEAC treatment prevents LPS-stimulated increases of proinflammatory cytokines, including TNF-α, IL-6, and IL-1β. In N27-A cells, MEAC treatment significantly upregulates antiapoptotic gene (Bcl-2) and antioxidant enzyme (HO-1, NQO1, and catalase) expressions. Moreover, MEAC treatment protects against MPP+-induced death in N27-A cells. To conclude, A cepa extract takes protective action against LPS and MPP+, and upregulates the antioxidant enzymes that could potentially be used in the therapy of NDDs.
Comparative Physiological and Biochemical Changes in Tomato (Solanum lycopersicum L.) under Salt Stress and Recovery: Role of Antioxidant Defense and Glyoxalase Systems
Authors: Parvin Khursheda , Hasanuzzaman Mirza , Bhuyan M. H. M. Borhannuddin , Nahar Kamrun , Mohsin Sayed Mohammad , Fujita Masayuki
Published: September 2019

Salinity toxicity and the post-stress restorative process were examined to identify the salt tolerance mechanism in tomato, with a focus on the antioxidant defense and glyoxalase systems. Hydroponically grown 15 day-old tomato plants (Solanum lycopersicum L. cv. Pusa Ruby) were treated with 150 and 250 mM NaCl for 4 days and subsequently grown in nutrient solution for a further 2 days to observe the post-stress responses. Under saline conditions, plants showed osmotic stress responses that included low leaf relative water content and high proline content. Salinity induced oxidative stress by the over-accumulation of reactive oxygen species (H2O2 and O2•−) and methylglyoxal. Salinity also impaired the non-enzymatic and enzymatic components of the antioxidant defense system. On the other hand, excessive Na+ uptake induced ionic stress which resulted in a lower content of other minerals (K+, Ca2+, and Mg2+), and a reduction in photosynthetic pigment synthesis and plant growth. After 2 days in the normal nutrient solution, the plants showed improvements in antioxidant and glyoxalase system activities, followed by improvements in plant growth, water balance, and chlorophyll synthesis. The antioxidant and glyoxalase systems worked in concert to scavenge toxic reactive oxygen species (ROS), thereby reducing lipid peroxidation and membrane damage. Taken together, these findings indicate that tomato plants can tolerate salinity and show rapid post-stress recovery by enhancement of their antioxidant defense and glyoxalase systems.
Serum Free Thiols Are Superior to Fecal Calprotectin in Reflecting Endoscopic Disease Activity in Inflammatory Bowel Disease
Authors: Bourgonje Arno R. , Gabriëls Ruben Y. , de Borst Martin H. , Bulthuis Marian L. C. , Faber Klaas Nico , van Goor Harry , Dijkstra Gerard
Published: September 2019

Oxidative stress plays a pivotal role in the pathogenesis of inflammatory bowel diseases (IBD). Serum free thiols (R-SH) reliably reflect systemic oxidative stress, since they are readily oxidized by reactive species. Here, we aimed to establish concentrations of serum free thiols in IBD and assessed their discriminating capacity regarding endoscopic disease activity. Albumin-adjusted serum free thiol concentrations were measured in 78 IBD patients (31 Crohn’s disease (CD) and 47 ulcerative colitis (UC) patients) and 50 healthy controls and analyzed for associations with disease parameters and their discriminative value regarding endoscopic disease activity (n = 54) or fecal calprotectin (n = 36) in patients for which those data were available. Mean serum free thiol concentrations were significantly lower in both CD and UC as compared to healthy controls (19.4 ± 3.1 and 17.8 ± 3.4 vs. 21.1 ± 1.9 µmol/g albumin, P < 0.001). Free thiols highly accurately discriminated between mild and moderate-to-severe disease activity, better than fecal calprotectin (FC) levels (AUC = 0.87, P < 0.001 vs. AUC = 0.76, P < 0.05, respectively) and this was maintained after cross-validation (AUC = 0.89, P < 0.001). Serum free thiols are reduced in IBD as compared to healthy controls and strongly correlate with the degree of endoscopic disease activity. Quantifying systemic redox status in IBD may be a promising, minimally invasive strategy to monitor IBD disease activity.
Selenocysteine β-Lyase: Biochemistry, Regulation and Physiological Role of the Selenocysteine Decomposition Enzyme
Authors: Seale Lucia A.
Published: September 2019

The enzyme selenocysteine β-lyase (SCLY) was first isolated in 1982 from pig livers, followed by its identification in bacteria. SCLY works as a homodimer, utilizing pyridoxal 5’-phosphate as a cofactor, and catalyzing the specific decomposition of the amino acid selenocysteine into alanine and selenide. The enzyme is thought to deliver its selenide as a substrate for selenophosphate synthetases, which will ultimately be reutilized in selenoprotein synthesis. SCLY subcellular localization is unresolved, as it has been observed both in the cytosol and in the nucleus depending on the technical approach used. The highest SCLY expression and activity in mammals is found in the liver and kidneys. Disruption of the Scly gene in mice led to obesity, hyperinsulinemia, glucose intolerance, and hepatic steatosis, with SCLY being suggested as a participant in the regulation of energy metabolism in a sex-dependent manner. With the physiological role of SCLY still not fully understood, this review attempts to discuss the available literature regarding SCLY in animals and provides avenues for possible future investigation.
Lyophilized Maqui (Aristotelia chilensis) Berry Induces Browning in the Subcutaneous White Adipose Tissue and Ameliorates the Insulin Resistance in High Fat Diet-Induced Obese Mice
Authors: Sandoval Viviana , Femenias Antoni , Martínez-Garza Úrsula , Sanz-Lamora Hèctor , Castagnini Juan , Quifer-Rada Paola , Lamuela-Raventós Rosa , Marrero Pedro , Haro Diego , Relat Joana
Published: September 2019

Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A–stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities.
Femtosecond Laser Processing of Thick Film Cathodes and Its Impact on Lithium-Ion Diffusion Kinetics
Authors: Pfleging Wilhelm , Gotcu Petronela
Published: September 2019

Quantitative experiments of lithiation/delithiation rates were considered for a better understanding of electrochemical intercalation/deintercalation processes in laser structured thick film cathodes. Besides galvanostatic cycling for evaluation of specific discharge capacities, a suitable quantitative approach for determining the rate of Li-ion insertion in the active material and the rate of Li-ion transport in the electrolyte is expressed by chemical diffusion coefficient values. For this purpose, the galvanostatic intermittent titration technique has been involved. It could be shown that laser structured electrodes provide an enhanced chemical diffusion coefficient and an improved capacity retention at high charging and discharging rates.
An Assessment of the Role of Ice Hydrometeor-Types in WRF Bulk Microphysical Schemes in Simulating Two Heavy Rainfall Events over Southern Nigeria
Authors: Akinola Oluseyi Ezekiel , Yin Yan
Published: September 2019

The role of ice hydrometeor-types in bulk schemes available in the Weather Research and Forecasting (WRF) model has been assessed in this study to simulate two heavy rainfall events reported over the southern part of Nigeria. This has been done with a view to provide necessary information on the convective cloud hydrometeor types and compositions in the area to improve heavy rainfall forecasts with the selection of appropriate bulk microphysical schemes. Results from the statistical validation of the simulated rainfall by different schemes showed that for the first event, the WSM5 scheme with less dense snow ice particles performed relatively better than other schemes like WSM6, Morrison with graupel (MORR_G), and Morrison with hail (MORR_H), while the WDM6 scheme performed least effectively when compared to TRMM data. Conversely, the second event showed that a WDM6 scheme with graupel as dense ice particle performed better than other schemes. Further analysis using a spatial distribution plot of simulated rainfall over the area of study shows that for both cases, almost all the schemes fail to capture the intensity and location of the heavy rainfall shown by TRMM data. In addition, the surface accumulated rainfall area average of all schemes for the first (second) event shows an underestimation (overestimation). Vertical profile plots of mass mixing ratios of different ice hydrometeor compositions showed that the WSM5 scheme contains a greater mass of snow than other type ice particles for both cases, while the hydrometeor path calculation of total mass content showed the WSM5 scheme having more snow mass content than other schemes during the period of analysis in both cases. A pressure-time plot of the differences between simulated air temperature and water vapor of the WSM5 scheme showed that WSM5 simulated the higher air temperature that was needed and water vapor at the mid and upper troposphere more than other schemes. In conclusion, results from this study has shown that less dense ice particle (e.g., snow) and high dense ice particle (e.g., graupel and hail) type-bulk schemes can both be suitable for simulating heavy rainfall events that are produced by convective system(s) that are common in the area.
Rational Design of an Orthogonal Pair of Bimolecular RNase P Ribozymes through Heterologous Assembly of Their Modular Domains
Authors: Nozawa Yuri , Hagihara Megumi , Rahman Md Sohanur , Matsumura Shigeyoshi , Ikawa Yoshiya
Published: September 2019

The modular structural domains of multidomain RNA enzymes can often be dissected into separate domain RNAs and their noncovalent assembly can often reconstitute active enzymes. These properties are important to understand their basic characteristics and are useful for their application to RNA-based nanostructures. Bimolecular forms of bacterial RNase P ribozymes consisting of S-domain and C-domain RNAs are attractive as platforms for catalytic RNA nanostructures, but their S-domain/C-domain assembly was not optimized for this purpose. Through analysis and engineering of bimolecular forms of the two bacterial RNase P ribozymes, we constructed a chimeric ribozyme with improved catalytic ability and S-domain/C-domain assembly and developed a pair of bimolecular RNase P ribozymes the assembly of which was considerably orthogonal to each other.