bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-wall carbon Nanotube surface-based functional nanoparticles for stimuli-responsive dual pharmaceutical compound delivery
Authors: Nabitabar Masoumeh , Shaterian Maryam , Danafar Hossein , Enhessari Morteza
Published: May 2024

Carbon nanotubes (CNTs) have the potential to serve as delivery systems for medicinal substances and gene treatments, particularly in cancer treatment. Co-delivery of curcumin (CUR) and Methotrexate (MTX) has shown promise in cancer treatment, as it uses fewer drugs and has fewer side effects. This study used MTX-conjugated albumin (BSA)-based nanoparticles (BSA-MTX) to enhance and assess the efficiency of CUR. In-vitro cytotoxicity tests, DLS, TEM, FTIR, UV/Vis, SEM, and DSC studies assessed the formulations' physical and chemical properties. The Proteinase K enzyme was used to severe amidic linkages between MTX and BSA. The findings demonstrated the efficacy of using ƒ-MWCNT-CUR-BSA-MTX as a vehicle for efficient co-delivery of CUR and MTX in cancer treatment. The MTT colorimetric method was used to evaluate the effect of chemical and medicinal compounds. Cell division was studied using the MTT method to investigate the effect of pure MWCNT, pure CUR, MTX-BSA, and ƒ-MWCNT-CUR-MTX-BSA. Studies on cell lines have shown that the combination of curcumin and MTX with CNT can increase and improve the effectiveness of both drugs against cancer. A combination of drugs curcumin and methotrexate simultaneously had a synergistic effect on MCF-7 cells, which indicated that these drugs could potentially be used as a strategy for both prevention and treatment of breast cancer. Also, ƒ-MWCNT-CUR-MTX-BSA was found to have a significant effect on cancer treatment with minimal toxicity compared to pure curcumin, pure MTX-BSA, MTX, and ƒ-MWCNT alone. Unique properties such as a high ratio of specific surface area to volume, high chemical stability, chemical adsorption ability, high capacity of drug and biomolecules of carbon nanotubes, as well as multiple drug loading at the same time The combination of ƒ-MWCNT-CUR-BSA MTX significantly impacts cancer therapy), are desirable as an alternative option for targeted drug delivery and high therapeutic efficiency.
Evaluation of dental plaque reduction using microcurrent-emitting toothbrushes in orthodontic patients: a randomized, double-blind, crossover clinical trial
Authors: Kim Ji-Hoi , Yu Jae-Hun , Mangal Utkarsh , Liu Jing , Jung Hyo-Jung , Cha Jung-Yul
Published: May 2024

This study aimed to compare the effectiveness of microcurrent-emitting toothbrushes (MCTs) and ordinary toothbrushes in reducing the dental plaque index (PI) and dental caries activity among orthodontic patients. The evaluation was performed using a crossover study design involving 22 orthodontic patients randomly assigned to the MCT or ordinary toothbrush groups. The participants used the designated toothbrush for 4 weeks and had a 1-week wash-out time before crossover to the other toothbrush. PI (Attin’s index) and dental caries activity were measured at baseline and at the end of each 4-week period. Additionally, patients completed questionnaires to assess patient satisfaction for “freshness in mouth” and “cleansing degree.” The results showed that the MCT group had a significant reduction in PI (p = 0.009), whereas the ordinary toothbrush group did not (p = 0.595). There was no significant difference in the dental caries activity between the two groups (p > 0.05). Patient satisfaction assessment revealed that 65% patients in the MCT group had more than “fair” experience of freshness, in contrast to 50% of patients in the ordinary toothbrush group. Satisfaction with cleansing degree was similar in both groups. Overall, these findings suggest that MCTs are more effective in reducing dental PI than ordinary toothbrushes.
The effect of social network based motivational interviewing on health behaviors among infertile women with polycystic ovary syndrome: A randomized controlled trial
Authors: Hamzehgardeshi Zeinab , Elyasi Forouzan , Moosazadeh Mahmood , Ahmadi Imaneh , Jahanfar Shayesteh , Ahmadian Maryam , Ansari Fatemeh
Published: May 2024

Polycystic ovary syndrome is one of the commonest and complex endocrine disorders in females of reproductive age. Attention to self-care behaviors such as health-promoting behaviors can improve physiological and psychological conditions in women with PCOS. This study aimed to determine the efficacy of Social Network-Based Motivational Interviewing on health-promoting behaviors and quality of life of infertile women with polycystic ovary syndrome. In this randomized controlled trial, 60 infertile women with polycystic ovary syndrome were randomly selected and assigned to the interventio (n = 30) or a control group (n = 30). Participants in the control group received routine care. Those in the intervention group received five motivational group sessions in WhatsApp, which were conducted in five groups of six participants each. The data related to health-promoting behaviors and quality of life were collected through an online questionnaire. Both groups were followed up immediately and 2 months after the intervention. Data collected in the two stages were analyzed using the paired-samples t-test, Chi-square, and repeated measures analysis. No significant difference was observed between the two groups before the intervention means health-promoting behaviors and quality of life scores (p>0.05). Immediately and two months after the intervention, the mean scores of health-promoting behaviors and their domains increased in the intervention group. This increase is statistically compared to the first test, and the scores obtained by the control group in the second (p< 0.001, ES = 1.5) and the third test (p< 0.001, ES= 1.3) were significant. The score of the quality of life variable increase was not statistically significant compared to the first test and also to the scores obtained by the control group. However According to the Generalized estimating equations (GEE) test, the changes in quality of life score between the two groups in the three stages of measurement are statistically significant. WhatsApp support increases the health-promoting self-care behaviors rate and has favorable effects on follow-up.

Trial registration: Iranian Registry for Clinical Trial (the link to trial: https://www.irct.ir/trial/48089). Registered August 11 2020.
Research on safety condition assessment methodology for single tower steel box girder suspension bridges over the sea based on improved AHP-fuzzy comprehensive evaluation
Authors: Su Huifeng , Guo Cheng , Wang Ziyi , Han Tao , Kamanda David Bonfils , Su Fengzhao , Shang Liuhong
Published: May 2024

In order to propose a reliable method for assessing the safety condition for single-tower steel box girder Suspension bridges over the sea, a condition monitoring system is established by installing sensors on the bridge structure. The system is capable of gathering monitoring data that influence the safety status of the bridge. These include cable tension, load on the main tower and pylon, bearing displacement, wind direction, wind speed, and ambient temperature and humidity. Furthermore, an improved Analytic Hierarchy Process (AHP) algorithm is developed by integrating a hybrid triangular fuzzy number logic structure. This improvement, coupled with comprehensive fuzzy evaluation methods, improves the consistency, weight determination, and security evaluation capabilities of the AHP algorithm. Finally, taking the No.2 Channel Bridge as an example and based on the data collected by the health monitoring system, the application of the safety assessment method proposed in this paper provides favorable results in evaluating the overall safety status of the bridge in practical engineering applications. This provides a basis for management decisions by bridge maintenance departments. This project confirms that the research results can provide a reliable method for assessing the security status of relevant areas.
A new single switch universal supply voltage DC-DC converter for PV systems with MGWM-AFLC MPPT controller
Authors: Touti Ezzeddine , Rafikiran Shaik , Aoudia Mouloud , Alrougy Ibrahim Mohammed , Khan Baseem , Ali Ahmed
Published: May 2024

The present power generation government companies focus on Renewable Power Sources (RPS) because their features are zero carbon footprint, unlimited power source, fewer greenhouse pollutants, fewer output wastages, plus creatinga very healthy atmosphere. In this work, the sunlight source is utilized for the Photovoltaic (PV) standalone network. The merits of sunlight sources are very optimal human resources needed, unlimited natural sources, plus easy operation. However, the solar power resource is nonlinear fashion. As a result, the operating point of the sunlight network fluctuates concerning sunlight intensity. So, in this article, the Modified Grey Wolf Methodology with Adaptive Fuzzy Logic Controller (MGWM-AFLC) is introduced to maintain the operating point of the sunlight system at the global power point position of the PV array. This controller traces the MPP with very low fluctuations in the PV-produced voltage. The advantages of this proposed method arefewer sensing devices required, less difficulty in development, more useful for rapid changes inthe sunlight temperatures, simpler to realize operation, greater economic growth, plus highly useful for household applications. The sunlight set-up generation voltage is lowwhich is improved by introducing the new Wide Power Rating High Voltage DC-DC Boost Converter (WPRHVBC). The features of this WPRHV converter are low voltage strain on semiconductor devices, few passive elements are enough to develop the circuit, plus easy understanding.
Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection
Authors: Bauer Angelika , Boehme Christian , Mayer-Suess Lukas , Rudzki Dagmar , Knoflach Michael , Kiechl Stefan , Reindl Markus
Published: May 2024

The systemic inflammatory response following acute ischaemic stroke remains incompletely understood. We characterised the circulating inflammatory profile in 173 acute ischaemic stroke patients by measuring 65 cytokines and chemokines in plasma. Participants were grouped based on their inflammatory response, determined by high-sensitivity C-reactive protein levels in the acute phase. We compared stroke patients’ profiles with 42 people experiencing spontaneous cervical artery dissection without stroke. Furthermore, variations in cytokine levels among stroke aetiologies were analysed. Follow-up samples were collected in a subgroup of ischaemic stroke patients at three and twelve months. Ischaemic stroke patients had elevated plasma levels of HGF and SDF-1α, and lower IL-4 levels, compared to spontaneous cervical artery dissection patients without stroke. Aetiology-subgroup analysis revealed reduced levels of nine cytokines/chemokines (HGF, SDF-1α, IL-2R, CD30, TNF-RII, IL-16, MIF, APRIL, SCF), and elevated levels of IL-4 and MIP-1β, in spontaneous cervical artery dissection (with or without ischaemic stroke as levels were comparable between both groups) compared to other aetiologies. The majority of cytokine/chemokine levels remained stable across the study period. Our research indicates that stroke due to large artery atherosclerosis, cardioembolism, and small vessel occlusion triggers a stronger inflammatory response than spontaneous cervical artery dissection.
Enhancing grid resiliency in distributed energy systems through a comprehensive review and comparative analysis of islanding detection methods
Authors: Kulkarni Mangesh S , Mishra Sachin , Sudabattula Suresh Kumar , Sharma Naveen Kumar , Basha D. Baba , Bajaj Mohit , Tuka Milkias Berhanu
Published: May 2024

Reduction of fossil fuel usage, clean energy supply, and dependability are all major benefits of integrating distributed energy resources (DER) with electrical utility grid (UG). Nevertheless, there are difficulties with this integration, most notably accidental islanding that puts worker and equipment safety at risk. Islanding detection methods (IDMs) play a critical role in resolving this problem. All IDMs are thoroughly evaluated in this work, which divides them into two categories: local approaches that rely on distributed generation (DG) side monitoring and remote approaches that make use of communication infrastructure. The study offers a comparative evaluation to help choose the most efficient and applicable IDM, supporting well-informed decision-making for the safe and dependable operation of distributed energy systems within electrical distribution networks. IDMs are evaluated based on NDZ outcomes, detection duration, power quality impact, multi-DG operation, suitability, X/R ratio reliance, and efficient functioning.
From density functional theory to machine learning predictive models for electrical properties of spinel oxides
Authors: Elbaz Yuval , Caspary Toroker Maytal
Published: May 2024

This work focuses on predicting and characterizing the electronic conductivity of spinel oxides, which are promising materials for energy storage devices and for the oxygen evolution and oxygen reduction reactions due to their attractive properties and abundance of transition metals that can act as active sites for catalysis. To this end, a new database was developed from first principles, including band structure and conductivity properties of spinel oxides, and machine learning algorithms were trained on this database to predict electronic conductivity and band gaps based solely on the compositions. The models developed in this study are scaled from the quantum level up to a continuum conductivity model. The relatively small database used in this study allowed for accurate predictions of band gap and conductivity. By altering the composition of spinel oxides, the model was able to predict high conductivity for spinels with high nickel content and to match experimental trends for manganese cobalt spinels. The ability to predict material properties is especially important in energy conversion devices such as batteries and supercapacitors where redox reactions take place.
Advanced stability analysis of a fractional delay differential system with stochastic phenomena using spectral collocation method
Authors: Xie Mengqi , Khan Sami Ullah , Sumelka Wojciech , Alamri Atif M. , AlQahtani Salman A.
Published: May 2024

In recent years, there has been a growing interest in incorporating fractional calculus into stochastic delay systems due to its ability to model complex phenomena with uncertainties and memory effects. The fractional stochastic delay differential equations are conventional in modeling such complex dynamical systems around various applied fields. The present study addresses a novel spectral approach to demonstrate the stability behavior and numerical solution of the systems characterized by stochasticity along with fractional derivatives and time delay. By bridging the gap between fractional calculus, stochastic processes, and spectral analysis, this work contributes to the field of fractional dynamics and enriches the toolbox of analytical tools available for investigating the stability of systems with delays and uncertainties. To illustrate the practical implications and validate the theoretical findings of our approach, some numerical simulations are presented.
LncRNA TUG1 mediates microglial inflammatory activation by regulating glucose metabolic reprogramming
Authors: He Chunxiang , Li Ze , Yu Wenjing , Luo Rongsiqing , Zhou Jinyong , He Jiawei , Chen Qi , Song Zhenyan , Cheng Shaowu
Published: May 2024

Microglia are natural immune cells in the central nervous system, and the activation of microglia is accompanied by a reprogramming of glucose metabolism. In our study, we investigated the role of long non-coding RNA taurine-upregulated gene 1 (TUG1) in regulating microglial glucose metabolism reprogramming and activation. BV2 cells were treated with Lipopolysaccharides (LPS)/Interferon-γ (IFN-γ) to establish a microglial activation model. The glycolysis inhibitor 2-Deoxy-D-glucose (2-DG) was used as a control. The expression levels of TUG1 mRNA and proinflammatory cytokines such as Interleukin-1β (IL-1β), Interleukin -6, and Tumor Necrosis Factor-α mRNA and anti-inflammatory cytokines such as IL-4, Arginase 1(Arg1), CD206, and Ym1 were detected by RT-qPCR. TUG1 was silenced using TUG1 siRNA and knocked out using CRISPR/Cas9. The mRNA and protein expression levels of key enzymes involved in glucose metabolism, such as Hexokinase2, Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Lactate dehydrogenase, Glucose 6 phosphate dehydrogenase, and Pyruvate dehydrogenase (PDH), were determined by RT-qPCR and Western blotting. The glycolytic rate of microglial cells was measured using Seahorse. Differential metabolites were determined by metabolomics, and pathway enrichment was performed using these differential metabolites. Our findings revealed that the expression of TUG1 was elevated in proinflammatory-activated microglia and positively correlated with the levels of inflammatory factors. The expression of anti-inflammatory cytokines such as IL-4, Arg1, CD206, and Ym1 were decreased when induced with LPS/IFN-γ. However, this decrease was reversed by the treatment with 2-DG. Silencing of GAPDH led to an increase in the expression of TUG1 and inflammatory factors. TUG1 knockout (TUG1KO) inhibited the expression of glycolytic key enzymes and promoted the expression of oxidative phosphorylation key enzymes, shifting the metabolic profile of activated microglia from glycolysis to oxidative phosphorylation. Additionally, TUG1KO reduced the accumulation of metabolites, facilitating the restoration of the tricarboxylic acid cycle and enhancing oxidative phosphorylation in microglia. Furthermore, the downregulation of TUG1 was found to reduce the expression of both proinflammatory and anti-inflammatory cytokines under normal conditions. Interestingly, when induced with LPS/IFN-γ, TUG1 downregulation showed a potentially beneficial effect on microglia in terms of inflammation. Downregulation of TUG1 expression inhibits glycolysis and facilitates the shift of microglial glucose metabolism from glycolysis to oxidative phosphorylation, promoting their transformation towards an anti-inflammatory phenotype and exerting anti-inflammatory effects in BV2.
Assimilation of PSO and SVR into an improved ARIMA model for monthly precipitation forecasting
Authors: Parviz Laleh , Ghorbanpour Mansour
Published: May 2024

Precipitation due to its complex nature requires a comprehensive model for forecasting purposes and the efficiency of improved ARIMA (IARIMA) forecasts has been proved relative to the conventional models. This study used two procedures in the structure of IARIMA to obtain accurate monthly precipitation forecasts in four stations located in northern Iran; Bandar Anzali, Rasht, Ramsar, and Babolsar. The first procedure applied support vector regression (SVR) for modeling the statistical characteristics and monthly precipitation of each class, IARIMA-SVR, which improved the evaluation metrics so that the decrease of Theil's coefficient and average relative variance in all stations was 21.14% and 17.06%, respectively. Two approaches are defined in the second procedure which includes a forecast combination (C) scheme, IARIMA-C-particle swarm optimization (PSO), and artificial intelligence technique. Generally, most of the time, IARIMA-C-PSO relative to the other approach, exhibited acceptable results and the accuracy improvement was greater than zero at all stations. Comparing the two procedures, it is found that the capability of IARIMA-C-PSO is higher concerning the IARIMA-SVR, so the decrease in the normalized mean squared error value from IARIMA to IARIMA-SVR and IARIMA-C-PSO is 36.72% and 39.92%, respectively for all stations. The residual predictive deviation (RPD) of IARIMA-C-PSO for all stations is greater than 2, which indicates the high performance of the model. With a comprehensive investigation, the performance of Bandar Anzali station is better than the other stations. By developing an improved ARIMA model, one can achieve a high performance in structure identifying and forecasting of monthly time series which is one of the issues of interest and importance.
Olfactory bulb-medial prefrontal cortex theta synchronization is associated with anxiety
Authors: Mooziri Morteza , Samii Moghaddam Ali , Mirshekar Mohammad Ali , Raoufy Mohammad Reza
Published: May 2024

Anxiety is among the most fundamental mammalian behaviors. Despite the physiological and pathological importance, its underlying neural mechanisms remain poorly understood. Here, we recorded the activity of olfactory bulb (OB) and medial prefrontal cortex (mPFC) of rats, which are critical structures to brain’s emotional processing network, while exploring different anxiogenic environments. Our results show that presence in anxiogenic contexts increases the OB and mPFC regional theta activities. Also, these local activity changes are associated with enhanced OB-mPFC theta power- and phase-based functional connectivity as well as OB-to-mPFC information transfer. Interestingly, these effects are more prominent in the unsafe zones of the anxiogenic environments, compared to safer zones. This consistent trend of changes in diverse behavioral environments as well as local and long-range neural activity features suggest that the dynamics of OB-mPFC circuit theta oscillations might underlie different types of anxiety behaviors, with possible implications for anxiety disorders.
Cyborg insect repeatable self-righting locomotion assistance using bio-inspired 3D printed artificial limb
Authors: Montagut Marques Marc Josep , Yuxuan Qiu , Sato Hirotaka , Umezu Shinjiro
Published: May 2024

Cyborg insects have emerged as a promising solution for rescue missions, owing to their distinctive and advantageous mobility characteristics. These insects are outfitted with electronic backpacks affixed to their anatomical structures, which endow them with imperative communication, sensing, and control capabilities essential for effecting survivor retrieval. Nevertheless, the attachment of supplementary loads to the insect’s body can exert adverse effects on their intrinsic self-righting locomotion when confronted with fall or shock scenarios. To address this challenge, the present study introduces a bio-inspired 3D-printed artificial limb that serves to facilitate the maneuverability of cyborg insects amidst unpredictable conditions. Drawing inspiration from the natural self-righting motion exhibited by Coccinellidae, we have successfully identified a solution that can be transferred to the electronic backpack utilized by G. portentosa. Incorporation of the bio-inspired artificial wing-like limb has notably enabled the cyborg insect to achieve a remarkable tilting angle of 112°, thereby significantly amplifying the success ratio of self-righting under conditions closely emulating those prevalent in disaster areas. Moreover, we have replicated the expansion and contraction kinematics to ensure seamless motion progression within confined spaces. Importantly, the fabricated device proffered in this study has been meticulously designed for facile reproducibility employing commonly available tools, thereby serving as an inspirational catalyst for fellow researchers engaged in the advancement of 3D-printed limb development aimed at expanding the functional capacities of cyborg insects.
Boosting photocatalytic efficiency of iridium polypyridyl complex in coupling reaction through the induction of ferrocene: insights into bimetallic catalysis
Authors: Gayen Firdaus Rahaman , Chawla Sakshi , Bora Debashree , Borkotoky Lodsna , Gazi Sarifuddin , Mallick Dibyendu , Maurya Ram Awatar , De Arijit Kumar , Saha Biswajit
Published: May 2024

A bimetallic compound [Ir(ppy)2(fcbpy)]PF6 (2, ppy = 2-phenylpyridine; fcbpy = 4-ferrocenyl-2,2′-bipyridine) is synthesized, and its molecular structure is established by single crystal XRD.
Protective effect of vitexin against high fat-induced vascular endothelial inflammation through inhibiting trimethylamineN-oxide-mediated RNA m6A modification
Authors: Li Wenwen , Deng Zeyuan , Xiao Shuang , Du Qian , Zhang Mengru , Song Hailing , Zhao Caidong , Zheng Liufeng
Published: May 2024

A high-fat diet (HFD) is a major risk factor for cardiovascular disease.
Characterization of recombinant human lactoferrin expressed in Komagataella phaffii
Authors: Lu Xiaoning , Cummings Chad , Osuala Udodili A. , Yennawar Neela H. , Namitz Kevin E. W. , Hellner Brittney , Besada-Lombana Pamela B. , Peterson Ross D. , Clark Anthony J.
Published: May 2024

This work presents a thorough characterization of Helaina recombinant human lactoferrin (rhLF, Effera™) expressed in a yeast system at an industrial scale for the first time.
Chiral electrochemiluminescence for simultaneous enantiomeric detection of aspartic acid and phenylalanine
Authors: Kuang Rui , Xin Jianping , Liang Jiaqi
Published: May 2024

A potential-resolved dual-color ECL sensor, engineered for the concurrent detection of aspartic acid (Asp) and phenylalanine (Phe) enantiomers.
Self-supported Ru-doped NiMoO4 for efficient hydrogen evolution with 1000 mA cm−2 at a low overpotential
Authors: Xue Pengfei , Qiao Man , Miao Juhong , Tang Yujia , Zhu Dongdong , Guo Chunxian
Published: May 2024

This work reports the growth of self-supported Ru-doped NiMoO4 on commercial NiMo foam, which acts as a highly active and robust electrocatalyst for ampere-level current density hydrogen evolution.
First-principles study on structural stabilities, mechanical properties, and biaxial strain-induced superconductivity in Janus MoWC monolayer
Authors: Thasitha Sirinee , Tsuppayakorn-aek Prutthipong , Udomkijmongkol Anan , Khammuang Satchakorn , Kaewmaraya Thanayut , Hussain Tanveer , Bovornratanaraks Thiti , Kotmool Komsilp
Published: May 2024

Janus MoWC belongs to the Mo2C and W2C parent MXene. This study reveals that 2H-MoWC is more stable than the 1T phase. It is an excellent mechanical 2D material. Also, 2H-MoWC is a superconductor with a Tc of 1.6 K, which can be enhanced by applying biaxial strain, increasing Tc to 7 K.
The effect of an external magnetic field on the interaction of carbon monoxide with hematite
Authors: Chernavskii P. A. , Pankina G. V.
Published: May 2024

The effect of an external magnetic field on the activation energy (E*) of carbon monoxide interaction with hematite under isothermal conditions in the temperature range of 250 to 350 °C has been studied using in situ magnetometry.
Synthesis of N-GQDs/CuS/Cv-CNNs hydrogels and their performance in hexavalent chromium wastewater treatment
Authors: Wang Jianrong , Wang Luhua , Ren Yi , Zhao Hongfang , Li Hongxia , Niu Xiaohui , Zhang Deyi , Wang Yi , Wang Kunjie
Published: May 2024

The different types of point defects effectively enhance the adsorption and photocatalytic capacity of the N-GCC hydrogel, and the hydrogel structure has the ability to mitigate the risk of the material causing cuproptosis to life forms in nature.
Theoretical investigation of a chiral Brønsted acid (CBA)-catalyzed isomerization reaction of BCB: mechanism and origin of stereoselectivity
Authors: Wang Yu-Nuo , Wang Yang
Published: May 2024

The mechanism, role of catalyst and origin of stereoselectivity for the isomerization reaction of BCB catalyzed by a chiral Brønsted acid (CBA) have been revealed in detail using DFT calculations.
Bisindole-based small molecules as transmembrane anion transporters and potential anticancer agents
Authors: Salunke Swati Bansi , Save Shreyada N. , Roy Naveen J. , Naorem Ronedy , Sharma Shilpy , Talukdar Pinaki
Published: May 2024

A bisindole-based transmembrane anion antiporter, selectively toxic to the MCF-7 cancer cells, where chloride transport-induced homeostasis disruption triggered mitochondrial membrane depolarization, ROS generation, and lysosomal deacidification.
Modulation of support properties in flower-like Pt/Al2O3 nanosheet catalysts for dehydrogenation of cycloalkanes
Authors: Zhu Mengmeng , Hou Gang , He Chaoran , Liu Sibao , Liu Guozhu
Published: May 2024

Flower-like Pt/Al2O3 nanosheet catalysts with modulated support properties were developed by simply varying the calcination temperature for the dehydrogenation of cycloalkanes and the support property–performance relationship was correlated.
Lewis acid catalyzed [4+2] annulation of bicyclobutanes with dienol ethers for the synthesis of bicyclo[4.1.1]octanes
Authors: Nicolai Stefano , Waser Jérôme
Published: May 2024

Bicyclo[4.1.1]octanes (BCOs) were synthesized in up to quantitative yields through the formal [4+2] cycloaddition of aryl and alkyl bicyclobutane (BCB) ketones with dienol silyl ethers using Al(OTf)3 as a Lewis acid catalyst.
Nickel polyelectrolytes as hole transporting materials for organic and perovskite solar cell applications
Authors: Lee Jin Hee , Khawaja Kausar Ali , Shoukat Faiza , Khan Yeasin , Kim Do Hui , Cho Shinuk , Walker Bright , Seo Jung Hwa
Published: May 2024

Engineering interfacial materials for use between the active layer and the electrodes in organic and perovskite solar cells is one of the most effective ways to increase device efficiency.
Photonic integrated circuits through femtosecond laser waveguide writing in glass
Authors: Ceccarelli Francesco , Osellame Roberto
Published: May 2024

Integrated photonics is increasingly pivotal across various fields due to its inherent stability, scalability, and compactness. In the landscape of integrated photonic platforms, femtosecond laser writing is a novel microfabrication technique that is swiftly emerging as a strong contender to established photolithographybased methods. This paper presents a primer on the femtosecond laser writing process and explores its capabilities for creating versatile and reprogrammable processors. Furthermore, we examine the application of this technology to the realization of integrated devices designed to leverage the distinctive features of this technology for critical areas such as quantum information processing and astrophotonics.
Single photon avalanches diodes
Authors: Gulinatti Angelo
Published: May 2024

Twenty years ago the detection of single photons was little more than a scientific curiosity reserved to a few specialists. Today it is a flourishing field with an ecosystem that extends from university laboratories to large semiconductor manufacturers. This change of paradigm has been stimulated by the emergence of critical applications that rely on single photon detection, and by technical progresses in the detector field. The single photon avalanche diode has unquestionably played a major role in this process.
Entschleunigtes Atmen: zu einfach, um wahr zu sein?
Authors: Loew Thomas H. , Leinberger Beate
Published: May 2024

4 Sekunden einatmen – 6 Sekunden ausatmen, für wenigstens 3 Minuten ändert Vieles: Entschleunigte
Atmung ist eine niederschwellige und äußerst effektive Intervention zur Selbstregulation.
Komorbidität und Persönlichkeitsstörungen
Authors: Trinkler Catharina
Published: May 2024

Die Behandlung komorbider Persönlichkeitsstörungen bedeutet auf der Grundlage eines kategorialen Störungsverständnisses zwar zumeist die Behandlung einer Komorbidität bzw. eines komorbiden klinischen Syndroms; praktisch wird vielmehr ein komplexes Störungssystem erlebbar, da nicht nur das syndromal beschreibbare Leiden behandelt wird, sondern auch – oder insbesondere – die psychisch-konstitutionellen Grundlagen für den individuellen Umgang damit.
„Love me tender, love me sweet, but don’t touch me too deep” – „Borderliner*innen”
und ihre Angehörigen
Authors: Aguilar-Raab Corina , Ochs Matthias
Published: May 2024

Borderline-Persönlichkeitsstörungen (BPS) werden vor dem Hintergrund systemischer Konzepte zu
spezifischen Interaktions- und Kommunikationsmustern sowie Formen der Organisation von Ambivalenzen und
Antagonismen reflektiert. Herausforderungen für Partner*innen und Familienangehörige und wie das
Mehr-Personen-Setting als „Möglichkeitsraum“ für psychotherapeutische Ressourcen genutzt werden kann.
Persönlichkeitsstörungen und HiTOP-Diagnostik
Authors: Hopwood Christopher J.
Published: May 2024

Der Beitrag stellt die Hierarchische Taxonomie der Psychopathologie (HiTOP) vor, vergleicht sie mit bestehenden diagnostischen Systemen auf der Grundlage des medizinischen Modells und erklärt, wie Persönlichkeitsstörungen aus einer HiTOP-Perspektive verstanden werden können.
Therapie der Borderline-Persönlichkeitsstörungen – Aktueller Stand der
dialektisch-behavioralen Therapie (DBT)
Authors: Strunk Leonie , Kröger Christoph
Published: May 2024

Seit der Aufnahme der Borderline-Persönlichkeitsstörung (BPS) in das Diagnostic and Statistical Manual
of Mental Disorders (DSM) im Jahr 1980 wurden Fortschritte in der Entwicklung von
psychotherapeutischen Behandlungen erzielt. Konträr zu anderen Persönlichkeitsstörungen wurden für die
BPS verschiedene störungsspezifische Behandlungsprogramme entwickelt, die auf unterschiedlichen
ätiologischen und therapietheoretischen Konzepten beruhen.
OPD-3 und Persönlichkeitsstörungen: Diagnostik, Indikation, Intervention,
Evaluation
Authors: Ehrenthal Johannes C.
Published: May 2024

Die Operationalisierte Psychodynamische Diagnostik (OPD) ist ein im deutschsprachigen Raum etabliertes
und in Praxis, Forschung, Versorgung und Weiterbildung verbreitetes System, das wesentliche
psychodynamische Konstrukte in Diagnostik und Therapieplanung integriert. Im Folgenden werden in
Ergänzung zu früheren Texten1,2
zentrale Aspekte der Anwendung im Bereich der Persönlichkeitsstörungen beschrieben.
A Model for Causality of Pitching-related Overuse Injuries in Women’s
Fastpitch Softball
Authors: Holtz Kaila A. , Zaremski Jason L. , Janosky Joseph , Friesen Kenzie B. , Oliver Gretchen D.
Published: May 2024

Fastpitch softball is a popular women’s sport, and athletes, particularly
pitchers, are at high risk for overuse injury. Softball-related injury rates are
low; however, the prevalence of overuse injuries is high. Injuries at the high
school and collegiate levels occur early in the season, and approximately 50% of
shoulder and elbow injuries in softball are attributable to overuse. Survey
research showed 77% of high school pitchers pitch with pain, and 73% of
collegiate pitchers reported an overuse injury in the previous season.
Modifiable and non-modifiable intrinsic and extrinsic risk factors contribute to
injury risk in a model that can be used in history taking, clinical examination,
and management of softball-related injuries. In this manuscript, we present a
scoping review of fastpitch softball injury research by competitive levels from
1990 to present. We also introduce a model for overuse injury causality in this
athlete population. With this information, clinicians will be able to identify
risk factors related to injury in softball pitchers. More research is needed to
make evidence-based recommendations for injury prevention in this athlete
population.
Effects of whole-body vibration training on lower extremity muscle
strength and physical function in elderly patients with
sarcopenia
Authors: Zhang Haixia , Huang Zhibin , Li Yige , Fan Zhijiao , Ma Quansheng , Yubao M.A. , Zhang Lihua
Published: May 2024

Objectives To investigate the feasibility and benefits of WBV training in
enhancing muscle strength and physical performance in older inpatients with
sarcopenia.

Methods We included 40 patients with sarcopenia (mean age 85 years; age
range 80~90 years) and randomly separated into the WBV group or control (CON)
group. The WBV group underwent 8 weeks of conventional rehabilitation training
combined with WBV, whereas the CON group received 8 weeks of conventional
rehabilitation training alone. The primary outcome was maximal isometric muscle
strength. The secondary outcomes were the time-up-and-go test (TUGT), the
five-times sit-to-stand test (FTSST), the 6-m gait speed test, and the Morse
Fall Scale (MFS).

Results After an 8-week intervention, only the quadriceps and tibialis
anterior muscles in the CON group showed substantial gains in strength. In the
WBV group, significant increases were observed in iliopsoas (P<0.05),
quadriceps (P<0.01), hamstring(P<0.01), and tibialis anterior muscle
(P<0.01) respectively. For all physical performance assessments, improvements
were observed in both CON and WBV groups (P<0.05), the improvement in the WBC
group was greater than the CON group (P<0.05). However, there was no
significant difference in fall risk between the two groups (P>0.05).

Conclusion This result highlights a eight weeks of whole-body vibration
training can increase the lower-limb muscular strength and physical performance
of older inpatients with sarcopenia.
Construction of Three Novel Oxygen-Containing Cagelike Frameworks and Synthesis of their Energetic Derivatives
Authors: Zhang Yu , Luo Jun , Li Huan , Zhou Qi , Zhao Jingjing , Hou Tianjiao , Wang Guixiang , Zhu Long , Li Bing
Published: May 2024

Organic cagelike frameworks are important and versatile skeletons for developing prospective energetic compounds because of their high intrinsic density, symmetry, stability, and derivability. Herein, we show the construction of three novel cagelike frameworks including dioxaadamantane, dioxaproadamantane, and dioxatwistane from 9-oxabicyclo[3.3.1]nonane-2,6-diene. In addition, their energetic derivatives were also prepared and characterized. Compared with our previous works, the introduction of more oxygen atoms into the framework gives the corresponding energetic derivative a better oxygen balance, significantly higher density, and detonation properties. These results imply that the oxygen-containing framework has the potential to be used for preparing new 3D energetic compounds with superior energy performance.
Association between Neonatal Outcomes and Admission Hypothermia among Very Preterm Infants in Chinese Neonatal Intensive Care Units: A Multicenter Cohort Study
Authors: Hong Wenchao , Zhu Yanping , Wang Yanchen , Jiang Siyuan , Cao Yun , Gu Xinyue , Lee Shoo K. , Kuo Sheree , Sun Jianhua , Shi Yuan , Yan Chongbing , Li Mingxia , Gong Xiaohui
Published: May 2024

Objective We aimed to investigate the relationship between admission hypothermia and outcomes among very preterm infants (VPIs) in neonatal intensive care units (NICUs) in China. We also investigated the frequency of hypothermia in VPIs in China and the variation in hypothermia across Chinese Neonatal Network (CHNN) sites.

Study Design This retrospective cohort study enrolled infants with 240/7 to 316/7 weeks of gestation with an admission body temperature ≤37.5 °C who were admitted to CHNN-participating NICUs between January 1 and December 31, 2019.

Results A total of 5,913 VPIs were included in this study, of which 4,075 (68.9%) had hypothermia (<36.5 °C) at admission. The incidence of admission hypothermia varied widely across CHNN sites (9–100%). Lower gestational age (GA), lower birth weight, antenatal steroid administration, multiple births, small for GA, Apgar scores <7 at the 5th minute, and intensive resuscitation were significantly associated with admission hypothermia. Compared with infants with normothermia (36.5–37.5 °C), the adjusted odds ratios (ORs) for composite outcome among infants with admission hypothermia <35.5 °C increased to 1.47 (95% confidence interval [CI], 1.15–1.88). The adjusted ORs for mortality among infants with admission hypothermia (36.0–36.4 and <35.5 °C) increased to 1.41 (95% CI, 1.09–1.83) and 1.93 (95% CI, 1.31–2.85), respectively. Admission hypothermia was associated with a higher likelihood of bronchopulmonary dysplasia, but was not associated with necrotizing enterocolitis ≥stage II, severe intraventricular hemorrhage, cystic periventricular leukomalacia, severe retinopathy of prematurity, or sepsis.

Conclusion Admission hypothermia remains a common problem for VPIs in a large cohort in China and is associated with adverse outcomes. Continuous quality improvement of admission hypothermia in the future may result in a substantial improvement in the outcomes of VPIs in China.

Key Points
Computerized Surgical Planning in Face Transplantation
Authors: Shah Alay , Chinta Sachin , Rodriguez Eduardo D.
Published: May 2024

Face transplantation (FT) has emerged as a critical intervention for patients with complex facial deformities unsuitable for conventional reconstructive methods. It aims to restore essential functions such as facial expression, mastication, and speech, while also improving psychosocial health. The procedure utilizes various surgical principles, addressing unique challenges of craniofacial complexity and diverse injury patterns. The integration of Computerized Surgical Planning (CSP) leverages computer-aided technologies to enhance preoperative strategy, intraoperative navigation, and postoperative assessment. CSP utilizes three-dimensional computed tomography, printing, angiography, and navigation systems, enabling surgeons to anticipate challenges and reduce intraoperative trial and error. Through four clinical cases, including a groundbreaking combined face and bilateral hand transplant, CSP's role in FT is highlighted by its ability to streamline operative processes and minimize surgical revisions. The adoption of CSP has led to fewer cadaveric rehearsals, heightened operative precision, and greater alignment with preoperative plans. Despite CSP's advancements, it remains complementary to, rather than a replacement for, clinical expertise. The demand for technological resources and multidisciplinary teamwork is high, but the improved surgical outcomes and patient quality of life affirm CSP's value in FT. The technology has become a staple in reconstructive surgery, signaling a step forward in the evolution of complex surgical interventions.
Primary Spinal Malignant Melanoma Mimicking a Cervical Nerve Root Schwannoma: Case Report and Literature Review
Authors: Gold Justin , Hernandez Nick R. , Wong Timothy , Patel Nitesh , Weiner Joseph , Hanft Simon
Published: May 2024

Primary spinal malignant melanoma (PSMM) is a rare cancer of the central nervous system (CNS), and PSMM of the spinal nerve root is even more extraordinary. PSMM of a nerve root can mimic the radiographic appearance of benign nerve sheath tumors, thus resulting in misdiagnosis until tissue diagnosis can be made. A 53-year-old African American woman presented with pain primarily involving the left aspect of her neck and shoulder for 2 years. Magnetic resonance imaging (MRI) of the cervical spine demonstrated a T1-hyperintense, T2-hypointense, homogenously enhancing, dumbbell-shaped, intradural extramedullary mass extending out through the left C2–3 foramen. A midline incision was used to perform a C2 and C3 laminectomy, and the mass was removed from the cavity. The histopathologic profile was consistent with the diagnosis of malignant melanoma. The present case report adds to the 110 cases of PSMM and the 20 cases of PSMM of the spinal nerve root in the existing body of literature. Radiographic and clinical features resemble that of the much more common schwannoma or neurofibroma requiring immunohistochemical analysis for definitive diagnosis. The optimal treatment for PSMM has not yet been defined due to its rarity and it is therefore important to report such cases in order to share our clinical experiences and provide data to other clinicians treating this uncommon disease.
Intradiscal Osteotomy and Bilateral Expandable Transforaminal Interbody Fusion Cages for Iatrogenic Kyphotic Deformity: A Technical Report
Authors: Hudson Joseph S. , Legarreta Andrew , Fields Daryl P. , Deng Hansen , McCarthy David J. , Sefcik Roberta , Agarwal Nitin , Hamilton David K.
Published: May 2024

Objectives Expandable transforaminal interbody fusion (TLIF) devices have been developed to introduce more segmental lordosis through a narrow operative corridor, but there are concerns about the degree of achievable correction with a small graft footprint. In this report, we describe the technical nuances associated with placing bilateral expandable cages for correction of iatrogenic deformity.

Materials and Methods A 60-year-old female with symptomatic global sagittal malalignment and a severe lumbar kyphotic deformity after five prior lumbar surgeries presented to our institution. We performed multilevel posterior column osteotomies, a L3–4 intradiscal osteotomy, and placed bilateral lordotic expandable TLIF cages at the level of maximum segmental kyphosis.

Results We achieve a 21-degree correction of the patient's focal kyphotic deformity and restoration of the patient global sagittal alignment.

Conclusion This case demonstrates both the feasibility and utility of placing bilateral expandable TLIF cages at a single disc space in the setting of severe focal sagittal malalignment. This technique expands the implant footprint and, when coupled with an intradiscal osteotomy, allows for a significant restoration of segmental lordosis.
The Περὶ ἀντιστοίχων in MS. Barocci 10 and
MS. Barocci 48
Authors: Roussou Stephanie
Published: May 2024

This article brings to light an unpublished treatise on orthographically different but phonetically identical
vowels entitled Περὶ ἀντιστοίχων and transmitted in manuscripts Barocci 10 (14th/15th century) and Barocci 48 (15th century), both
kept in the Bodleian library in Oxford. The Περὶ ἀντιστοίχων is one of the many orthographical works composed to help with the
spelling problems that arose in the Greek language due to the fact that over the centuries the sound of certain Greek vowels
became identical, thus making the spelling of words a real challenge. As well as providing the editio princeps
for this text, this article discusses its history and background, its features, and its relationship with other grammatical and
lexicographical sources, primarily with Pseudo-Zonaras’ Lexicon, and suggests that the Περὶ ἀντιστοίχων is
possibly an indirect witness to Pseudo-Zonaras’ Lexicon.
Low-Voltage IGZO Field-Effect Ultraviolet Photodiode
Authors: Song 宋 Shuang 双 , Liang 梁 Huili 会力 , Huo 霍 Wenxing 文星 , Zhang 张 Guang 广 , Zhang 张 Yonghui 永晖 , Wang 王 Jiwei 绩伟 , Mei 梅 Zengxia 增霞
Published: May 2024

In the era of Internet of Things (IoTs), an energy-efficient ultraviolet (UV) photodetector (PD) is highly desirable considering the massive usage scenarios such as environmental sterilization, fire alarm and corona discharge monitoring. So far, common self-powered UV PDs are mainly based on metal-semiconductor hetero-structures or p–n heterojunctions, where the limited intrinsic built-in electric field restricts further enhancement of the photoresponsivity. In this work, an extremely low-voltage field-effect UV PD is proposed using a gate-drain shorted amorphous IGZO (a-IGZO) thin film transistor (TFT) architecture. A combined investigation of the experimental measurements and technology computer-aided design (TCAD) simulations suggests that the reverse current (I
R) of field-effect diode (FED) is highly related with the threshold voltage (V
th) of the parental TFT, implying an enhancement-mode TFT is preferable to fabricate the field-effect UV PD with low dark current. Driven by a low bias of −0.1 V, decent UV response has been realized including large UV/visible (R
300/R
550) rejection ratio (1.9 × 103), low dark current (1.15 × 10−12 A) as well as high photo-to-dark current ratio (PDCR, ∼ 103) and responsivity (1.89 A/W). This field-effect photodiode provides a new platform to construct UV PDs with well-balanced photoresponse performance at a low bias, which is attractive for designs of large-scale smart sensor networks with high energy efficiency.