bluuebunny/crossref_metadata_2025 huggingface dataset:
Il gioco con le costruzioni e lo sviluppo cognitivo: una review narrativa
Authors: Pirrone Concetta , Castellano Sabrina , Amata Concetta Giuseppa , Tienken Christopher
Published: December 2021

Il gioco rappresenta per il bambino un'attività fondamentale per la sua crescita; in particolare, quello con le costruzioni, sembra avere un ruolo rilevante per lo sviluppo cognitivo del bambino. Al fine di comprenderne la reale efficacia, numerosi studi sono stati condotti indagandone i vari aspetti in relazione a differenti abilità cognitive. Una prima area di studi riguarda la relazione tra gioco con le costruzioni e abilità visuo-spaziali, una seconda ne esamina la relazione con la matematica, una terza area mette in relazione il gioco con le costruzioni, le abilità visuo-spaziali, l'intelligenza numerica - nelle sue diverse componenti - e le immagini mentali. Tali studi lasciano presupporre che il gioco con le costruzioni rappresenti un importante strumento ludico ed educativo con elevate capacità per il potenziamento dello sviluppo cognitivo complessivo e di specifiche abilità, quali quelle matematiche. Questa rassegna narrativa propone dunque una revisione sistematica delle evidenze empiriche presenti in letteratura per tentare di comprenderne la reale efficacia. In un periodo storico in cui i device informatici stanno gradualmente sostituendo il gioco manuale che da sempre ha accompagnato lo sviluppo umano, conoscere lo stato dell'arte su questo importante ambito di ricerca potrebbe rappresentare uno spunto di riflessione al fine di rivedere la programmazione scolastica basata sul possibile ritorno a specifiche attività ludiche manuali finalizzate al potenziamento cognitivo e di specifiche abilità scolastiche.
La Vita di Dante per Francesco Lomonaco. Un esule dimenticato
Authors: Landolfi Francesco
Published: December 2021

L'articolo si pone l'obiettivo di analizzare la figura letteraria di Dante attraverso gli occhi di Francesco Lomonaco (1772-1810), intellettuale lucano protagonista della rivoluzione partenopea del 1799 e, successivamente al suo fallimento, insegnante di storia e geografia presso la Scuola militare di Pavia dal 1805. Secondo il principio per cui laddove è presente una lingua unica sussiste anche un'identità di nazione unita, Lomonaco introduce nella sua opera Vite degli eccellenti italiani (1802) Dante come il padre della letteratura italiana, su cui è necessario fondare l'identità dei moderni italiani. L'importanza di Dante nel pensiero di Lomonaco è dovuta anche alle sfortunate e consimili vicissitudini che entrambi affrontarono come esuli per cause politiche: il primo lasciando Firenze, il secondo fuggendo da Napoli. Una somiglianza di esistenze che fu addirittura immortalata da Alessandro Manzoni in un sonetto dedicato proprio al suo amico Lomonaco.
Inflation and Macroeconomics in the US during the Golden Age
Authors: Spinato Morlin Guilherme
Published: December 2021

This paper reviews interpretations of the moderate inflation observed in the US during the 1950s and early 1960s. In this period, moderate and persistent inflation disconcerted economists and challenged policymakers. The opposition between demand-pull and cost-push views stimulated different interpretations, as sectorial demand-shift inflation theory and the modified Phillips curve. As policy targeted growth and employment, incomes policy was applied to contain inflation. The pa-per provides an overview of explanations to the moderate inflationary process in light of the historical events of the Golden Age of capitalism.
Vertebrate diversity at Margalla Hills National Park, Pakistan
Authors: Aslam I , Yasmeen R.
Published: December 2021

The Margalla Hills National Park (MHNP) in Islamabad, Pakistan, is an important site for the conservation of many plants and animals. The present study aimed to determine the status of fauna diversity and richness, and environmental threats to the animals. A field study was conducted and the point count method was used to determine vertebrate diversity. The survey showed that the MHNP is home to 117 species of birds, 27 reptiles (including species such as the saw–scaled viper, Russell’s viper and the Indian cobra) and 30 mammalian species, such as barking deer, wild boar, golden jackal, red fox, Asiatic leopards, monkeys, fruit bats, and pangolins. The results showed a maximum count of 9,076 birds of 117 species belonging to 48 families. According to the Islamabad wildlife management board, one of the unique species, the grey goral (Nemorhaedus goral), has become extinct at the MHNP as no single specimen has been recorded since 2018. It was also been observed, however, that the numbers of the endangered species of common leopard (Panthera pardus) and pangolin (Manis crassicaudata) have increased, possibly due to the wildlife management board’s strategy for conservation. Nevertheless, greater conservation and protection of wild fauna at the MHNP is still needed. During the visits, threats such as habitat degradation, climate change, and over hunting were recorded.
Dataset published through GBIF (Doi: 10.15470/hf1s9i)
Протестний перформанс як форма безпосередньої участі членів територіальної громади у здійсненні місцевого самоврядування
Authors: Луцков В.
Published: December 2021

У статті досліджується протестний перформанс як форма безпосередньої участі членів територіальної громади у здійсненні місцевогосамоврядування. Автором розкрита конституційно-правова природа перформансу, позитивні та негативні сторони протестного перформансу, його зв’язок із суміжними інститутами; розглянуті перспективи розвитку протестного перформансу у правовому полі.
Активне виборче право на місцевих виборах в Україні
Authors: Корнієнко В.
Published: December 2021

У статті розглядаються проблемні аспекти реалізації активного виборчого права на місцевих виборах в Україні. Окрему увагу приділено таким категоріям, як військовослужбовці, внутрішньо переміщені особи, іноземці, які постійно мешкають у територіальній громаді, засуджені. Запропоновано зміни до виборчого законодавства з урахуванням європейських виборчих стандартів.
LOGISTICS FLEXIBILITY, RELATIONSHIP FLEXIBILITY, AND LOGISTICS SERVICE QUALITY: THE MODERATING ROLE OF ENVIRONMENTAL UNCERTAINTY
Authors: Ercan Esra , Çelik Mazlum
Published: December 2021

This study examined the moderating role of environmental uncertainty on the connection between logistics flexibility, relationship flexibility, and logistics service quality. This study covered large and medium- sized companies operating in the Gaziantep Organized Industrial Zone. Company lists were created based on records in the Gaziantep Chamber of Industry. A questionnaire was sent to a total of 1627 companies by e-mail and company managers were asked to fill in the online questionnaire. The managers of 356 companies fully completed the questionnaire. SPSS Process Macro V3.4 was used to calculate the moderator effects of environmental uncertainty. The macro also reported the effect level of independent variables on dependent variables. According to the results of the analysis, logistics flexibility and relationship flexibility affected logistics service quality, positively and significantly. Besides, environmental uncertainty had a moderator role in the relationship between logistics flexibility and logistics service quality. There were some limitations. A questionnaire was used as a data collection tool in the study. Thus, personal perceptions of the participants could be apparent in the information given about the company since questionnaire data was formed in accordance with statements given by the respondents. In future researches, it is recommended that measurement tools that can determine environmental uncertainty more objectively could be used on a sectoral basis to secure clearer results. It is recommended that companies take into account environmental uncertainty when determining a strategy(s) to enhance the quality of logistics services.
PREDICTION OF SHARE OF VISUAL INVENTORY USING STORE DISPLAY, CHANNEL, AND PRODUCT VARIABLES
Authors: Saldanha Avil Terrance , Desai Rajendra , Aranha Rekha
Published: December 2021

The purpose of this study is to predict the share of visual inventory (SOVI), which is defined as the number of stock-keeping units (SKUs) of a company’s products, calculated as a percentage of the total SKUs on the display of all products. Research studies in the past have focused mainly on the impact of inventory, which includes back end and visual inventory, on sales but less attention has been given to the impact of SOVI on sales. To address this research gap, this study attempted to create an analytics model to predict SOVI at the category of soft drinks level using four predictor variables namely point of purchase display, channel/sub-channel, package group, product category, and derived variable gross national income (GNI). The results were encouraging confirming the effectiveness of such a model. The researchers utilized a data set collected over a period of 18 months (February 2016 to July 2017) by a soft drink firm headquartered in the United States. Based on the findings, it is suggested that this prediction model can be utilized by other researchers and practitioners to predict SOVI of other soft drinks, fast-moving consumer goods (FMCG), and food and beverage companies.
The Peloponnesian War, the Spanish Requirement and the Clash of Civilizations: An Application of Plato's Theaetetus
Authors: Hamblet Wendy C.
Published: December 2021

This paper applies a unique reading of Plato's Theaetetus to problems of modern political violence. Theateteus' exploration of knowledge in his philosophical "birthings" under Socrates' midwifery reveals the elusiveness of human definitions of such crucial terms as justice. This leads them to the Protagorean dilemma, that when definitions are elusive, anyone and any state can name things "just" as they see them. The danger is then considered in relation to the ostensibly clear and distinct term "civilization" to explore whether we are right in our intuition that this is an unambiguously good thing.
Giuseppe Garibaldi and Sweden: Between Solidarity and Scandinavism
Authors: Quirico Monica
Published: December 2021

The events of Italian Risorgimento and the attempts by Swedish Scandinavists (adherents to the intellectual movement seeking to establish one unified Nordic State) to return Sweden to an influential international role crossed each other. Whilst Sweden experienced both a constitutional crisis with Norway and a significant strengthening of the popular demand for democratic reforms, Piedmont was seen by the Scandinavists as a role model vis-à-vis the unification, in a democratic way, of different kingdoms under a crown that, in their plans, ought to be in the Nordic context the Swedish one. The solidarity movement supporting Garibaldi, identified as the symbol of the popular struggle against despotism, anticipated the prolonged and important season of Swedish popular movements, which were to play a crucial role in the history of Swedish Social Democracy.
On the Issue of Special Exercises in the Counterterrorism System Involving Specialists of Health Care Management Bodies, Medical Formations and Organizations
Authors:   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation, Titov I.G.
Published: December 2021

The objectives of the study are to analyze the experience of exercises conducted in the counter-terrorism system by specialists of the regional Disaster Medicine Service, to identify key organizational issues of preparation and implementation of exercises; to develop proposals for their improvement in the subject of elimination of medical and sanitary consequences of terrorist acts committed with the use of conventional means of destruction. Materials and research methods. Sources of information and materials studied: normative and methodological documents regulating the procedures of organizing and conducting military training in the field of healthcare; materials of trainings performed by specialists from regional EMC on the subject of organizing the liquidation of medical and sanitary consequences of terrorist acts; data from expert evaluation maps on the subject of the study; scientific papers and publications on technologies of training and exercises involving specialists from healthcare management bodies, medical units and organizations. The following scientific methods were used in the research: content analysis method, expert assessment method, statistical method, logical and informational modeling, and analytical method. Results of research and their analysis. The results of the study of basic organizational issues of preparing and conducting special exercises (command-staff exercise, staff training, tactical and special exercises) conducted in the regions with the participation of specialists of public health authorities, medical formations and organizations within the framework of counter-terrorism are presented. Sound proposals were made to improve the technology of preparing and conducting special exercises and communicating their results to medical specialists. The results of the study showed that almost all the experts (98.0%) were in full agreement with the need, in order to maintain and increase the preparedness of health care authorities, medical organizations, including emergency medical care and the Disaster Medicine Service, to conduct regional trainings on the subject of medical support of the population during terrorist acts. And only 2.0% of the experts had difficulty in formulating a specific conclusion on this issue.
Experience of Applying Telemedicine Technologies in the Work of Voronezh Regional Clinical Center for Disaster Medicine
Authors:   Voronezh State Medical University. N.N.Burdenko, Voronezh, Russian Federation, Mekhantieva L.E. , Artemov A.N. ,   Voronezh Regional Clinical Center of Disaster Medicine, Voronezh, Russian Federation, Ilyichev V.P. ,   Voronezh State Medical University. N.N.Burdenko, Voronezh, Russian Federation
Published: December 2021

The purpose of the study is to determine the role of telecommunication technologies in increasing the efficiency of Voronezh Regional Clinical Center for Disaster Medicine. Materials and methods of research. The data contained in analytical reports and other documentation of the Center for 2018-2020 in terms of identifying patterns of their change with the introduction of telecommunications technologies were analyzed. Results of the study and their analysis. Introduction of telemedicine technologies in the work of the Center resulted in increase of volume of rendering of medical care by its specialists. The neurosurgeons were the most demanded specialists, who performed telemedical consultations, which is mostly related to the necessity of performing consultations for the doctors of trauma centers of the II and III levels, engaged in treatment of victims of car accidents. Voronezh Regional Clinical Center for Disaster Medicine plans to further expand the use of telecommunication technologies not only in treating victims of road accidents, but also victims of other man-made and natural emergencies.
NEUROHÁBITAT DEL DISEÑO A LA SINAPSIS
Authors: Guzman Rafael Marcelino
Published: December 2021

¿Puede el diseño condicionar nuestra conducta? ¿Puede condicionar cómo nos sentimos? ¿Puede modificar nuestra mente? Al paso del tiempo la práctica del diseño ha sido sinónimo de estética, modernidad y estatus, ha sido modificada por los medios y las herramientas tecnológicas, lo cual ha llegado a permitir la creación de un hábitat construido fusionado entre la información digital y el mundo real que habitamos utilizando técnicas novedosas con las cuales interactuamos hoy. Este artículo describe un acercamiento a la base conceptual de un nuevo paradigma dentro del diseño en general llamado Neurohábitat un paradigma repleto de oportunidades para la investigación, que parte del hecho de que el objeto final de este hábitat diseñado y construido son los sujetos que lo habitan y experimentan. Esto simboliza una práctica transhumanista que antepone el desarrollo de la experiencia y vida humana, al beneficio económico, político o de otra naturaleza de los sujetos. La incorporación de la ciencia al diseño podría representar el surgimiento de un nuevo avance para los planteamientos metodológicos y teóricos de la disciplina dentro de un mundo cada vez más cambiante y digitalizado.

Palabras clave: Diseño, neurociencias, cognición, hábitat.

AbstractCan design condition our behavior? Can it condition the way we feel? Can it modify our mindset? Over time, the practice of design has been synonymous with aesthetics, modernity and status, it has been modified by the media and technological tools, which has come to allow the creation of a built habitat fused between digital information and the real world we inhabit using novel techniques with which we interact today. This article describes an approach to the conceptual basis of a new paradigm within design in general called Neurohabitat, a paradigm full of opportunities for research, which starts from the fact that the final object of this designed and built habitat is the subjects that inhabit it. and they experiment. This symbolizes a transhumanist practice that puts the development of human experience and life before the economic, political or other benefits of the subjects. The incorporation of science into design could represent the emergence of a new advance for the methodological and theoretical approaches of the discipline within an increasingly changing and digitized world.

Keywords Design: neurosciences, cognition, habitat.
Maaseudulla kaupungissa
Authors: Tuulentie Seija , Kantola Sini
Published: December 2021

Artikkelissa tarkastellaan vuorovaikutteisuutta ja kansalaisten osallistumismahdollisuuksia laaja-alaisen pohjoisen kaupungin maaseutualueiden suunnittelussa. Pohjois-Suomessa kaupunkikeskustojen ulkopuoliset maat ovat usein julkisessa omistuksessa, ja samoja alueita kohtaan kohdistuu monenlaisia maankäytön intressejä. Artikkelissa pohditaan yhtenä mahdollisuutensa osallistavan paikkatietomenetelmän (PPGIS) käyttöä osallistamisen apuna. Artikkeli perustuu rovaniemeläisten viranomaisten, paikallispoliitikkojen ja sidosryhmien edustajien haastatteluihin. Osallistamisen haasteiden nähtiin liittyvän ennen kaikkea heikkoon viestintään, luottamuksen puutteeseen eri osapuolten välillä sekä tiedonkulun ongelmiin. Asenteet karttakyselyitä kohtaan olivat positiiviset, mutta kaikenlaisen osallistavan tiedon hyödyntämistä pidettiin heikkona. Luontoarvojen ja asukkaiden mielipiteiden katsottiin olevan vaarassa jäädä taloudellisten arvojen varjoon.
Mitä asemakaava määrää?
Authors: Jaakonaho Mari
Published: December 2021

Asemakaavoituksella on tärkeä rooli resurssiviisaan kaupungin rakentumisen ohjaamisessa. Vähäisen tutkimuksenvuoksi sekä asemakaavoituksen sisällön kehittäminen että kaavaohjauksesta käytävä keskustelu ovat pintapuolisia. Tämä tutkimus pohjautuu Vantaalla vuosina 2015–2019 hyväksyttyihin 152 asemakaavaan. Se esittää viisi resurssiviisaan kaupungin aineistolähtöisesti muodostettua ulottuvuutta: nämä ovat materiaalitehokas kaupunki, ilmastonkestäväkaupunki, kestävän liikkumisen kaupunki, terveellinen ja turvallinen kaupunki sekä sosiaalisesti kestävä kaupunki. Tutkimus käsittelee näiden ulottuvuuksien ja niiden eri teemojen esiintymistiheyttä ja sen muutosta tarkastelujaksolla. Lisäksi työ analysoi kaavatyön yhteydessä tehdyn teknisen ilmastovaikutuslaskennan (KEKO) vaikutusta asemakaavojen sisältöön.
MORAL AND SOCIAL SUPPORT STATUSES AND DEPRESSIVE SYMPTOMS OF PATIENTS AGED 65 AND OVER WHO HAVE CHRONIC OBSTRUCTIVE LUNG DISEASE
Authors: ÜNSAL Ayla , KARAKURT Papatya
Published: December 2021

The current study was undertaken to determine status of morale, social support and depressive symptoms among patients aged ≥ 65 years old with chronic obstructive pulmonary disease. This study conducted in a descriptive and correlational design. The data were collected using patient descriptive forms developed by the researchers, a personal information form about the disease, Philadelphia Geriatric Center Morale Scale, the Multidimensional Scale of Perceived Social Support and Geriatric Depression Scale through face to face interview method. For the analyses of the data; percentages, means, Mann Whitney U, Kruskall Wallis and Correlation Analyses tests were employed.The rate of patients currently smoking was 6.2% whereas the rate of patients previously smoking was 60.6%. It was found that 50.9% of the elderly COPD patients had severe depression and their average depression score was 13.76±5.02, their average morale score was 5.78±2.11 and their average social support score was 54.71±16.80. It was found that there was a negative and significant correlation between morale and social support status of the elders whereas there was no correlation between morale and depression symptoms. It was identified that elderly COPD patients had lower morale status, moderate social support status and more than half of them demonstrated depressive symptoms. While morale levels of the patients decreased, their social support status increased. It is recommended that sufficient support systems should be provided to the elders in order to reduce their depression symptoms and to elevate their morale levels.
Toxoplasma gondii Induces Apoptosis via Endoplasmic Reticulum Stress-Derived Mitochondrial Pathway in Human Small Intestinal Epithelial Cell-Line
Authors: Wang Hao , Li Chunchao , Ye Wei , Pan Zhaobin , Sun Jinhui , Deng Mingzhu , Zhan Weiqiang , Chu Jiaqi
Published: December 2021

Toxoplasma gondii, an intracellular protozoan parasite that infects one-third of the world’s population, has been reported to hijack host cell apoptotic machinery and promote either an anti- or proapoptotic program depending on the parasite virulence and load and the host cell type. However, little is known about the regulation of human FHs 74 small intestinal epithelial cell viability in response to T. gondii infection. Here we show that T. gondii RH strain tachyzoite infection or ESP treatment of FHs 74 Int cells induced apoptosis, mitochondrial dysfunction and ER stress in host cells. Pretreatment with 4-PBA inhibited the expression or activation of key molecules involved in ER stress. In addition, both T. gondii and ESP challenge-induced mitochondrial dysfunction and cell death were dramatically suppressed in 4-PBA pretreated cells. Our study indicates that T. gondii infection induced ER stress in FHs 74 Int cells, which induced mitochondrial dysfunction followed by apoptosis. This may constitute a potential molecular mechanism responsible for the foodborne parasitic disease caused by T. gondii.
Failure of Repeated MDA with Albendazole for Trichuriasis Control in Schoolchildren of the Yangon Region, Myanmar
Authors: Hong Sooji , Jung Bong-Kwang , Song Hyemi , Cho Jaeeun , Sohn Woon-Mok , Hong Sung-Jong , Ryu Jin-Youp , Kim Hyun-Seung , Jeong Mun-Hyoo , Htoon Thi Thi , Tin Htay Htay , Chai Jong-Yil
Published: December 2021

Soil-transmitted helminth (STH) infections are still a considerable challenge in Myanmar. We undertook a control program for STH infections (especially Trichuris trichiura) among schoolchildren in Myanmar using mass drug administration (MDA) and health education. Around 1,700 schoolchildren from 15 primary schools in 3 suburban districts (Shwe Pyi Thar, Twantay, and Kyauktan) of the Yangon Region were subjected in this study during 2017-2019. All of the schoolchildren in each school were orally administered albendazole (400 mg in a single dose) 2, 3, and 4 times a year in 2017, 2018, and 2019, respectively. The results revealed that the egg positive rate of any intestinal helminths (including STH) was reduced from 37.6% (649/1,724) in 2017 to 22.8% (352/1,542) in 2019. The egg positive rate of Ascaris lumbricoides was decreased remarkably from 23.3% (402/1,724) in 2017 to 3.6% (56/1,542) in 2019. However, that of T. trichiura was only slightly reduced from 26.9% (464/1,724) in 2017 to 20.2% (312/1,542) in 2019. The intensity of infection with A. lumbricoides and T. trichiura was both more or less reduced, and the proportion of light infection cases with A. lumbricoides and T. trichiura increased from 35.6% in 2017 to 64.3% in 2019 and from 70.3% in 2017 to 81.7% in 2019, respectively. The results indicated that repeated MDAs (2-4 times a year for 3 years) using albendazole on schoolchildren in Myanmar failed to control T. trichiura infection. For a successful control of trichuriasis in Myanmar, new MDA strategies, using a modified albendazole regimen (multiple daily doses for 2 or 3 days) or an alternative anthelmintic drug, such as oxantel pamoate, is strongly recommended.
Оценка коррозионной агрессивности атмосферы и прогноз коррозионных потерь металлов
Authors: ПАНЧЕНКО Юлия Михайловна , МАРШАКОВ Андрей Игоревич , ИГОНИН Тимофей Николаевич , НАЗМЕЕВА Татьяна Вильсовна
Published: December 2021

Показана необходимость пересмотра отечественных нормативных документов в области атмосферной коррозии, коррозионной агрессивности атмосферы, методов определения коррозионных потерь за разные сроки. Рассмотрены современные подходы к оценке коррозионной агрессивности атмосферы: для больших территорий или регионов - по описанию типичных атмосферных условий эксплуатации, для небольших территорий или городов - по коррозионным потерям за первый год. Приведена математическая модель функции "доза - ответ" для прогноза коррозионных потерь углеродистой стали за первый год эксплуатации с использованием климатических параметров атмосферы, а также степенная-линейная модель для прогноза долговременных коррозионных потерь, соответствующая современным представлениям о кинетике коррозии. В модели использованы коэффициенты, представленные в международном стандарте и разработанные отечественными исследователями. Показано, что более достоверные результаты получены с использованием разработок академического института не только для территории России, но и для всех регионов мира. Дана сравнительная оценка картографирования континентальной территории России по коррозионным потерям углеродистой стали за первый год и 50 лет по модели с коэффициентами, разработанными академическим институтом и представленными в международном стандарте. Дано обоснование приоритетности коэффициентов, разработанных в академическом институте.
Методы определения групп взаимосвязанных организаций, участвующих в инвестиционно-строительном процессе
Authors: КОГАН Юлия Викторовна
Published: December 2021

В статье обосновывается актуальность определения групп юридически взаимосвязанных организаций для решения прикладных задач. Целью определения таких групп является координация инвестиционно-строительного процесса и анализ градостроительной деятельности в столице. Основной объект исследования - юридические лица, участвующие в проектировании и строительстве объектов недвижимости различного функционального назначения на территории Москвы. Представлена типология групп организаций в зависимости от организации-учредителя, ведомственной подчиненности, истории реорганизации и организационно-правовой формы юридических лиц. При определении групп юридически взаимосвязанных организаций рекомендуется использовать официальные документы, публикуемые в открытом доступе, которые могут актуализироваться на регулярной основе. Разработаны методические основы для формирования перечней групп взаимосвязанных организаций, которые объединяют крупнейших застройщиков, осуществляющих свою деятельность на территории столицы. Определение групп юридически взаимосвязанных организаций позволяет решать оперативные организационные задачи, а также анализировать масштабы и динамику их деятельности, в том числе в территориальном разрезе.
Прогнозирование укрупненного графика затрат при реализации крупномасштабных городских проектов
Authors: АРГУНОВ Сергей Владимирович , СЕМЕНОВ Сергей Александрович
Published: December 2021

Рассмотрены цели формирования укрупненного графика затрат на строительство объектов при реализации крупномасштабных городских проектов. Показан метод укрупненного расчета затрат на капитальное строительство, который основан на объемных показателях, сформированных на этапе подготовки градостроительной документации, предельных значениях стоимости производства и реализации единицы объема. Разработан алгоритм распределения затрат по годам капитального строительства. В модели реализован учет вероятности изменения сроков строительства объектов. Представленные методы и алгоритмы апробированы на примере Программы реновации жилищного фонда города Москвы. Установлено, что данные методы и алгоритмы можно использовать для ранней оценки объемов затрат при реализации крупномасштабных проектов капитального строительства, а также для обоснования расходов в долгосрочной перспективе.
Методы типизации характеристик квартир в жилых домах
Authors: ГРИШУТИН Илья Борисович , МИНАКОВ Сергей Сергеевич , КРОТОВА Дарья Андреевна
Published: December 2021

Обоснована актуальность использования одного из аспектов типового проектирования - применения универсальной квартирографии домов, которые предназначены для переселения жителей по Программе реновации жилищного фонда города Москвы. Приведены методы анализа квартирографии подлежащих отселению домов и принципы формирования универсальной квартирографии. Кроме того, апробация метода рассмотрена на примере анализа квартирографии отселяемых домов района Метрогородок в Москве. В результате была сформирована универсальная квартирография отселяемого жилищного фонда данной территории, которая была апробирована на группах "волнового" переселения. Полученные результаты показали эффективность использования универсальной квартирографии при переселении жителей по программе реновации. Типовые методы позволили повысить качество проектирования благодаря повторному применению отработанных планировочных решений, ускорить разработку проектной документации на строительство и удешевить ее стоимость.
Türkiye'deki İç Mimarlık Firmalarının Ahşap Malzemeleri Kullanımı ve Tercih Düzeyleri
Authors: DEĞİRMENTEPE Selim , ÇOLAK Mehmet
Published: December 2021

Bu çalışmada, iç mimarlık firmalarının, iç ve dış mekânlarda ahşap malzemeleri mobilya ve yapı malzemesi olarak kullanımları ve tercihleri araştırılmıştır. Bu araştırmanın amacı; iç mimarlık firmalarının ahşap malzemeler ile ilgili görüşlerini ve ahşap malzeme kullanma eğilimlerini belirlemektir. Araştırma kapsamında; iç mimarlık firmaları üzerine bir araştırma yapılması amacıyla basit tesadüfi örneklem yöntemi ile tespit edilen ve Türkiye genelini temsil edebilecek olan İstanbul, Ankara ve İzmir illeri seçilmiştir. 272 iç mimarlık firmasının yöneticilerine anket uygulaması gerçekleştirilmiş ve anket tekniği ile katılımcılar tarafından soruların cevaplandırılması üzerine elde edilen veriler analiz edilmiştir. Sonuç olarak; araştırma yapılan işletmelerin, ahşap malzemelerin kullanım olanaklarının yüksek olduğu düşüncesine yeteri kadar katılım sağlamadığı belirlenmiştir. Malzeme tercihi durumlarına bakıldığında, iç mekânlara kıyasla dış mekânlarda ahşap malzemeleri hem mobilya hem de yapı malzemesi olarak işletmeler tarafından daha düşük seviyede tercih edildiği tespit edilmiştir. İç ve dış mekânlarda hem mobilya hem de yapı malzemesi olarak en çok masif ahşap malzemenin tercih edildiği görülmüştür.
Competitive models of safe development of Ukraine in conditions of institutional instability and global environmental challenges
Authors:   SI “Institute of Regional Research named after M. I. Dolishniy of NAS of Ukraine”, MOKIY Anatoliy , ANTONIUK Kateryna ,   Zaporizhzhia Polytechnic National University, ILIASH Olha ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, FLEYCHUK Mariya ,   Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies
Published: December 2021

The article considers the prerequisites and mechanisms for the formation of competitive security strategies for socio-economic development of the state in the entropy of the global environment. Conceptual bases of security for implementing the macromodel of the state social and economic development are analyzed, that, in particular, provides: dismantling the system of clan capitalism, de-shadowing of economy and counteraction to corruption, safety of consumption and balanced limited social and economic development and application of bionic management paradigm of economic security based on a unified fiscal accounting payment system. This model should provide the basic preconditions for happiness and self-reproduction of citizens: social justice in the distribution of public goods and overcoming poverty, combating corruption, comfortable economic climate, strengthening economic security and confidence in the future by stabilizing macroeconomic indicators over time. This will allow forecasting the needs of consumer, financial, investment, innovation markets in the strategic perspective and other indicators, which will be a prerequisite for sustainable safe development and full consideration of the interests of future generations.
International economy: deepening and expanding research potential in Ukraine
Authors:   West Ukrainian National University, SAVELIEV Yevhen , KURYLYAK Vitalina ,   West Ukrainian National University
Published: December 2021

The topical issues of the development of the research potential of Ukraine in the field of international economics , capable of creating scientific support for the foreign economic activity of entrepreneurial structures and government organizations in the context of world and European integration, have been investigated. The creation of the infrastructure of research organizations specializing in the international economics has been substantiated, in particular, the feasibility of creating research institutes in the USA and Canada, Europe, and the Center for International Agricultural Business. The article considers the expediency of conducting research on the issues of cooperation with interstate integration associations of countries, including the EU, ASEAN, TPP, APEC, BRICS, for the implementation of the country's foreign economic policy. A special place in the system of international economics research should be occupied by the problems of Industry 4.0 and the leadership of Ukrainian IT companies in the system of global economic competition. The state of the staffing of research activities in international economics is analyzed and proposals for training of highly qualified specialists in international economics in large industrial centers: Kharkov, L’viv. Dnieper, Odessa and Zaporizhia are formulated.
THE EFFECT OF WILD HONEY (Apis dorsata Fabr.) CONCENTRATIONS ON PH AND ORGANOLEPTIC VALUES OF ULTRA HIGH TEMPERATURE (UHT) MILK
Authors: Palilati Selawati , Fahrullah  , Korompot Ishak
Published: December 2021

The research aims to observe the effect of addition wild honey (Apis dorsata Fabr.) on pH and organoleptic values of ultra high temperature milk (UHT). The research was  done using an experimental method using a non-factorial completely randomized design with five levels using SPSS 16. Different concentrations of wild honey (A1= control; A2= 5%; A3= 10%; A4= 15% and A5=20%) were used. The data was statistically analyzed using analysis of variance (ANOVA) with 5% significance level and further processed with Duncan's Multiple Range Test (DMRT). Organoleptic tests for colour, taste and overall preference were also done using qualitative tests (scores). The value of pH gave a significant value (P<0,01) between treatment. The higher the use of  wild honey concentration, the lower the pH value produced. The higher the concentration of wild honey, the higher the organoleptic value. The best treatment in terms of colour, taste, and level of preference was observed in the sample with the 20% honey concentration, each of which resulted in an average score of 4.
Genetic and Mitochondrial Metabolic Analyses of an Atypical Form of Leigh Syndrome
Authors: Uittenbogaard Martine , Sen Kuntal , Whitehead Matthew , Brantner Christine A. , Wang Yue , Wong Lee-Jun , Gropman Andrea , Chiaramello Anne
Published: December 2021

In this study, we aimed to establish the mitochondrial etiology of the proband’s progressive neurodegenerative disease suggestive of an atypical Leigh syndrome, by determining the proband’s pathogenic variants. Brain MRI showed a constellation of multifocal temporally disparate lesions in the cerebral deep gray nuclei, brainstem, cerebellum, spinal cord along with rhombencephalic atrophy, and optic nerve atrophy. Single voxel 1H MRS performed concurrently over the left cerebral deep gray nuclei showed a small lactate peak, increased glutamate and citrate elevation, elevating suspicion of a mitochondrial etiology. Whole exome sequencing revealed three heterozygous nuclear variants mapping in three distinct genes known to cause Leigh syndrome. Our mitochondrial bioenergetic investigations revealed an impaired mitochondrial energy metabolism. The proband’s overall ATP deficit is further intensified by an ineffective metabolic reprogramming between oxidative phosphorylation and glycolysis. The deficient metabolic adaptability and global energy deficit correlate with the proband’s neurological symptoms congruent with an atypical Leigh syndrome. In conclusion, our study provides much needed insights to support the development of molecular diagnostic and therapeutic strategies for atypical Leigh syndrome.
Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia
Authors: Zolotov Nikolay N. , Schepetkin Igor A. , Voronina Tatyana A. , Pozdnev Vladimir F. , Khlebnikov Andrei I. , Krylova Irina V. , Quinn Mark T.
Published: December 2021

Prolyl oligopeptidase (POP) is a large cytosolic serine peptidase that is altered in patients with Alzheimer’s disease, Parkinsonian syndrome, muscular dystrophies, and other denervating diseases. Thus, POP may represent a relevant therapeutic target for treatment of neuropsychiatric disorders and neurodegenerative diseases. Here, we report the characterization of five novel cyanopyrrolidine-based compounds (BocTrpPrdN, BocGlyPrdN, CbzMetPrdN, CbzGlnPrdN, and CbzAlaPrdN) and show that they are potent inhibitors of POP and are predicted to penetrate the blood-brain barrier (BBB). Indeed, we show that CbzMetPrdN penetrates the rat BBB and effectively inhibits POP in the brain when administered intraperitoneally. Furthermore, molecular modeling confirmed these compounds likely inhibit POP via interaction with the POP catalytic site. We evaluated protective effects of the cyanopyrrolidine-based POP inhibitors using scopolamine- and maximal electroshock-induced models of amnesia in rats and showed that BocTrpPrdN, BocGlyPrdN, CbzMetPrdN, and CbzGlnPrdN significantly prolonged conditioned passive avoidance reflex (CPAR) retention time when administered intraperitoneally (1 and 2 mg/kg) before evaluation in both models of amnesia, although CbzAlaPrdN was not effective in scopolamine-induced amnesia. Our data support previous reports on the antiamnesic effects of prolinal-based POP inhibitors and indicate an important role of POP in the regulation of learning and memory processes in the CNS.
Contributions of Hedgerows to People: A Global Meta-Analysis
Authors: García de León David , Rey Benayas José M. , Andivia Enrique
Published: December 2021

Hedgerows are linear landscape features of woody vegetation usually located around agricultural fields. An increasing number of studies have addressed the effects of hedgerows on biodiversity and ecosystem services. This study is aimed to synthesize these effects and compare the levels of biodiversity and ecosystem services in farmland with hedgerows and (1) farmland without hedgerows and (2) nearby natural habitat at the global scale. We hypothesized that farmland with hedgerows (1) enhances biodiversity and ecosystem services as compared to farmland without hedgerows but (2) supports lower levels of biodiversity and ecosystem services than natural habitat. Our systematic literature review retained 835 observations from 170 primary studies, which were analyzed following the standard methodology in meta-analyses. Our results partially support both hypotheses. Farmland with hedgerows exhibited higher levels of biodiversity and provisioning services than farmland without hedgerows (H1). Farmland with hedgerows provided similar levels of biodiversity (edge effects) but lower levels of ecosystem services than natural habitat (H2). The effects of hedgerows on biodiversity and ecosystem services depended on control ecosystem type (grassland/meadow or forest/woodland) but were largely independent of climate type (temperate or tropical) and the focus of spatial scale (field or landscape). In conclusion, conservation and restoration of hedgerows contribute to people in several ways by enhancing biodiversity and multifunctionality in agricultural landscapes.
Case Report: Fulminant Myocarditis Successfully Treated With Extracorporeal Membrane Oxygenation in Ikeda Strain Orientia tsutsugamushi Infection
Authors: Park Hyejin , Lim Yongwhan , Kim Min Chul , Kim Seong Eun , Jeong In-Seok , Choi Yoo Duk , Kim Dong-Min
Published: December 2021

Scrub typhus is an acute zoonotic febrile illness caused by Orientia tsutsugamushi having a specific geographic endemic area. This infection could be complicated with multi-organ involvement including myocarditis with variable severity. Here, we report a rare case of scrub typhus with biopsy-proven acute fulminant myocarditis which progressed very rapidly to cardiac arrest and was treated successfully with extracorporeal cardiopulmonary resuscitation. Clinicians should be alert to possible rapid progression of scrub typhus myocarditis to fulminant form and be prepared for close monitoring and temporary mechanical support if indicated.
The Food and Drug Administration Biologics Effectiveness and Safety Initiative Facilitates Detection of Vaccine Administrations From Unstructured Data in Medical Records Through Natural Language Processing
Authors: Deady Matthew , Ezzeldin Hussein , Cook Kerry , Billings Douglas , Pizarro Jeno , Plotogea Amalia A. , Saunders-Hastings Patrick , Belov Artur , Whitaker Barbee I. , Anderson Steven A.
Published: December 2021

Introduction: The Food and Drug Administration Center for Biologics Evaluation and Research conducts post-market surveillance of biologic products to ensure their safety and effectiveness. Studies have found that common vaccine exposures may be missing from structured data elements of electronic health records (EHRs), instead being captured in clinical notes. This impacts monitoring of adverse events following immunizations (AEFIs). For example, COVID-19 vaccines have been regularly administered outside of traditional medical settings. We developed a natural language processing (NLP) algorithm to mine unstructured clinical notes for vaccinations not captured in structured EHR data.

Methods: A random sample of 1,000 influenza vaccine administrations, representing 995 unique patients, was extracted from a large U.S. EHR database. NLP techniques were used to detect administrations from the clinical notes in the training dataset [80% (N = 797) of patients]. The algorithm was applied to the validation dataset [20% (N = 198) of patients] to assess performance. Full medical charts for 28 randomly selected administration events in the validation dataset were reviewed by clinicians. The NLP algorithm was then applied across the entire dataset (N = 995) to quantify the number of additional events identified.

Results: A total of 3,199 administrations were identified in the structured data and clinical notes combined. Of these, 2,740 (85.7%) were identified in the structured data, while the NLP algorithm identified 1,183 (37.0%) administrations in clinical notes; 459 were not also captured in the structured data. This represents a 16.8% increase in the identification of vaccine administrations compared to using structured data alone. The validation of 28 vaccine administrations confirmed 27 (96.4%) as “definite” vaccine administrations; 18 (64.3%) had evidence of a vaccination event in the structured data, while 10 (35.7%) were found solely in the unstructured notes.

Discussion: We demonstrated the utility of an NLP algorithm to identify vaccine administrations not captured in structured EHR data. NLP techniques have the potential to improve detection of vaccine administrations not otherwise reported without increasing the analysis burden on physicians or practitioners. Future applications could include refining estimates of vaccine coverage and detecting other exposures, population characteristics, and outcomes not reliably captured in structured EHR data.
Key Factors Needed for Developing a Higher Education Cross-Campus Learning Environment in a Nordic Context
Authors: Nykvist Shaun Sydney , De Caro-Barek Veruska , Støckert Robin , Lysne Dag Atle
Published: December 2021

The use of digital technologies and online tools to support both students and educators has become synonymous with transforming learning within Higher Education, particularly within post graduate courses. It can be argued that the recent push for transforming Higher Education aligns itself with the notion that postgraduate students need more flexible learning opportunities while still retaining access to high quality, engaging and collaborative pedagogical approaches. This paper reports on an exploratory case study that focuses on cross campus/university collaboration and flexible learning opportunities for students studying a masters level degree in the area of Music, Communication and Technology (MCT) within a Nordic context. The research question guiding the study is “What factors do educators in a hybrid cross-campus learning environment identify as essential for providing a supportive learning experience for students?” A pedagogy, space and technology (PST) framework underpins the development of this program and forms the basis for its development. The findings from our research identify three themes that need to be considered when attempting to design and implement high quality learning opportunities for students studying a largely synchronous hybrid music, communications and technology program. These themes were flexibility, trust and the human element, and ownership. The findings also highlight the need for a renewed focus on pedagogical approaches that can be adapted and continually revised to meet the changing needs of students in a synchronous hybrid learning space.
Learning by Comparison: The Benefits of Co-Teaching for University Professors’ Professional Development
Authors: Buckingham Lyndsay R. , López-Hernández Alfonso , Strotmann Birgit
Published: December 2021

There is an abundance of studies that suggest that the use of co-teaching strategies in higher education courses can enhance instructors’ professional development, mainly by providing a space for transfer of methodologies and tools, as well as critical reflection on one’s teaching practice. However, little has been said about the actual processes through which co-teachers learn from each other. This study analyzes the opportunities of professional growth afforded to seven professors by eight co-taught courses, over two academic years, in the fields of Education and Translation and Interpreting. Specifically, it examines how professional relationships between co-teachers fuel teacher learning, the specific learning processes generated, and the areas of professional development impacted. To do so, 11 reflective teacher diaries were coded and analyzed, and further evidence was collected through focus groups interviews with students of some of the co-taught courses. Results suggest that comparison with the co-teacher is the main force behind participants’ learning on co-teaching; furthermore, such comparisons enable three main learning processes: reflection, negotiation and transfer, bearing mainly on teaching methods and materials and use of technology. Finally, there is evidence that occasional or ongoing team teaching (two instructors simultaneously in class) can enhance the effectiveness of co-teacher comparisons.