bluuebunny/crossref_metadata_2025 huggingface dataset:
Are Women with Normal-Weight Obesity at Higher Risk for Cardiometabolic Disorders?
Authors: Ashtary-Larky Damoon , Niknam Sara , Alipour Meysam , Bagheri Reza , Asbaghi Omid , Mohammadian Mehrnaz , Jaime Salvador J. , Baker Julien S. , Wong Alexei , Suzuki Katsuhiko , Afrisham Reza
Published: January 2023

Objectives: This study aimed to evaluate the cardiometabolic abnormalities in women with normal-weight obesity (NWO) in comparison with lean, overweight, and obese women. Methods: This cross-sectional study evaluated the assessment of cardiometabolic abnormalities of women with NWO compared to lean, overweight, and obese women. NWO was defined as a BMI < 25 kg.m−2 and a BFP higher than 30%. Anthropometric variables, cardiometabolic abnormality markers (fasting blood glucose (FBG), blood pressure (BP), lipid profile, insulin resistance, and high-sensitivity C-reactive protein (hs-CRP)), and liver enzymes were also examined. Results: Significant differences were observed in HDL concentrations between NWO, lean, and obese participants (p < 0.05). There were no significant differences in FBG, insulin resistance, liver enzymes, or cholesterol between groups (p > 0.05). The prevalence of the abnormal metabolic phenotype was higher in NWO compared to the lean group (4.0% and 24.1%, respectively; p < 0.05). Women with type 2 and 3 obesity had abnormal metabolic profiles (60.9% and 73.9%, respectively) compared to NWO participants (p < 0.01). The NWO group had a significantly higher incidence of cardiometabolic abnormalities compared to the lean participants (p < 0.05), while the type 2 and 3 obese individuals had significantly higher incidences compared to the NWO group (p < 0.001 and p < 0.001, respectively). Conclusions: Individuals with NWO had a significantly higher incidence of cardiometabolic abnormalities when compared to lean participants. These abnormalities strongly relate to BFP and waist circumferences.
Network Analysis for the Discovery of Common Oncogenic Biomarkers in Liver Cancer Experimental Models
Authors: Cabral Loraine , Giraudi Pablo , Giannelli Gianluigi , Dituri Francesco , Negro Roberto , Tiribelli Claudio , Sukowati Caecilia
Published: January 2023

Hepatocellular carcinoma (HCC) is a malignancy marked by heterogeneity. This study aimed to discover target molecules for potential therapeutic efficacy that may encompass HCC heterogeneity. In silico analysis using published datasets identified 16 proto-oncogenes as potential pharmacological targets. We used an immortalized hepatocyte (IHH) and five HCC cell lines under two subtypes: S1/TGFβ-Wnt-activated (HLE, HLF, and JHH6) and the S2/progenitor subtype (HepG2 and Huh7). Three treatment modalities, 5 µM 5-Azacytidine, 50 µM Sorafenib, and 20 nM PD-L1 gene silencing, were evaluated in vitro. The effect of treatments on the proto-oncogene targets was assessed by gene expression and Western blot analysis. Our results showed that 10/16 targets were upregulated in HCC cells, where cells belonging to the S2/progenitor subtype had more upregulated targets compared to the S1/TGFβ-Wnt-activated subtype (81% vs. 62%, respectively). Among the targets, FGR was consistently down-regulated in the cell lines following the three different treatments. Sorafenib was effective to down-regulate targets in S2/progenitor subtype while PD-L1 silencing was able to decrease targets in all HCC subtypes, suggesting that this treatment strategy may comprise cellular heterogeneity. This study strengthens the relevance of liver cancer cellular heterogeneity in response to cancer therapies.
Augmented Ouabain-Induced Vascular Response Reduces Cardiac Efficiency in Mice with Migraine-Associated Mutation in the Na+, K+-ATPase α2-Isoform
Authors: Rajanathan Rajkumar , Pedersen Tina Myhre , Guldbrandsen Halvor Osterby , Olesen Lenette Foldager , Thomsen Morten B. , Bøtker Hans Erik , Matchkov Vladimir V.
Published: January 2023

Heterozygous mice (α2+/G301R mice) for the migraine-associated mutation (G301R) in the Na+,K+-ATPase α2-isoform have decreased expression of cardiovascular α2-isoform. The α2+/G301R mice exhibit a pro-contractile vascular phenotype associated with decreased left ventricular ejection fraction. However, the integrated functional cardiovascular consequences of this phenotype remain to be addressed in vivo. We hypothesized that the vascular response to α2-isoform-specific inhibition of the Na+,K+-ATPase by ouabain is augmented in α2+/G301R mice leading to reduced cardiac efficiency. Thus, we aimed to assess the functional contribution of the α2-isoform to in vivo cardiovascular function of wild-type (WT) and α2+/G301R mice. Blood pressure, stroke volume, heart rate, total peripheral resistance, arterial dP/dt, and systolic time intervals were assessed in anesthetized WT and α2+/G301R mice. To address rate-dependent cardiac changes, cardiovascular variables were compared before and after intraperitoneal injection of ouabain (1.5 mg/kg) or vehicle during atrial pacing. The α2+/G301R mice showed an enhanced ouabain-induced increase in total peripheral resistance associated with reduced efficiency of systolic development compared to WT. When the hearts were paced, ouabain reduced stroke volume in α2+/G301R mice. In conclusion, the ouabain-induced vascular response was augmented in α2+/G301R mice with consequent suppression of cardiac function.
Type 2 Diabetes Mellitus Coincident with Clinical and Subclinical Thyroid Dysfunctions Results in Dysregulation of Circulating Chemerin, Resistin and Visfatin
Authors: Tabandeh Mohammad Reza , Taha Amal Sattar , Addai Ali Hanaa , Razijalali Mohammad , Mohammadtaghvaei Narges
Published: January 2023

The alterations of circulating adipocytokines have been reported in thyroid diseases or type 2 diabetes mellitus (T2DM), but such data in T2DM coincident with clinical and subclinical thyroid-dysfunctions are limited, and remain to be investigated. We studied the changes in serum chemerin, resisitin and visfatin in T2DM patients with thyroid dysfunctions, and their association with inflammatory and insulin resistance-markers. A total of 272 female and male Iranian participants were selected and divided into six groups: the euthyroid group, T2DM, T2DM coincident with clinical and sub clinical hypothyroidism (SC-HO, and C-HO), and T2DM coincident with clinical and sub clinical hyperthyroidism (SC-HR, C-HR).Demographic characteristics, serum levels of adipocytokines, thyroid hormones, inflammatory factors (IL1-β, IL-6 and CRP) and insulin resistance-markers were determined in all participants. T2DM patients with clinical thyroid dysfunctions showed higher levels of circulating resistin, visfatin, chemerin and inflammatory factors, compared with the T2DM group and T2DM coexisted with subclinical thyroid diseases. No significant differences were observed in circulating adipocytokines and inflammatory markers between T2DM coexisting with subclinical thyroid diseases and those without thyroid dysfunctions. Our results revealed that clinical thyroid dysfunction in T2DM patients was associated with elevated levels of circulating resistin, chemerin, visfatin and inflammatory factors, while no such alteration was detected in T2DM coincident with subclinical thyroid dysfunction.
Sensing Bioavailable Water Content of Granulated Matrices: A Combined Experimental and Computational Study
Authors: Ghosh Ria , Bhattacharyya Neha , Banerjee Amrita , Roy Lopamudra , Mukherjee Debdatta , Singh Soumendra , Chattopadhyay Arpita , Adhikari Tapan , Pal Samir Kumar
Published: January 2023

This paper represents the synthesis, characterization and validation of a cobalt chloride functionalised nano-porous cellulose membrane, a unique sensor for non-contact measurement of water potential in various biomedical and environmentally important matrices. The developed nano sensor, along with associated electronic components, is assembled as a prototype device called “MEGH” (Measuring Essential Good Hydration) to measure essential hydration of matrices of both environmental and biomedical importance, including soil and human skin. The relative humidity above the soil surface in equilibrium with the soil moisture has been studied for both hydrophobic and hydrophilic soil types. Our studies confirm that the percentage of water available to plants is greater in hydrophobic soil rather than in hydrophilic soil, which has also been corroborated using simulation studies. Furthermore, the requirement of hydration in human skin has also been evaluated by measuring the water potential of both dry and moist skin.
Differences of Modality Use between Telepractice and Face-to-Face Administration of the Scenario-Test in Persons with Dementia-Related Speech Disorder
Authors: Gauch Mirjam , Corsten Sabine , Geschke Katharina , Heinrich Isabel , Leinweber Juliane , Spelter Bianca
Published: January 2023

Telepractice is increasingly finding its way into the care of people with dementia. Web-based delivery of speech and language therapy (SLT) is feasible and has the potential to improve communication in people with dementia-related speech disorders. Although experts are discussing the strengths and weaknesses of telepractice, a precise analysis of the differences between analogue and digital communication for this heterogeneous group of patients is still missing. The three current single cases investigated verbal and nonverbal aspects of communication in a face-to-face (F2F) and digital setting through a qualitative research design. Using the scenario-test (ST) in person and via big blue button (BBB; video conferencing system), several decisive factors were detected, influencing the effectiveness of communication in a F2F compared to a digital setting. The most important results of the qualitative content analysis are described for each case individually. Additionally, the influence of person-related factors, such as age, diagnosis, presence of depression, and level of education, is presented. Perceptual, executive, and affective disorders, as well as aids of relatives, are considered separately. The results indicate that executive functions, affects, and perceptual deficits need to be taken into account if telepractice is to be applied. Age, education, and distinct forms of dementia might be decisive for successful telepractice as well.
Development of L-Proline-Based Chiral Ionic Liquids for Asymmetric Michael Reaction
Authors: Zalewska Karolina , Pinto Isabel , Cabrita Luis , Zakrzewska Małgorzata E. , Noronha João P. , da Ponte M. Nunes , Branco Luis C.
Published: January 2023

Different Chiral Ionic Liquids (CIL) based on L-proline have been developed. Simple and efficient synthetic methodologies are used, allowing preparation in good yields for twelve novel CILs using L-proline as a cation or anion combined with suitable counter-ions. A detailed physical and chemical characterization of the CILs was performed to evaluate the influence of counter-ions on the final properties. The most promissory CILs were tested as efficient chiral catalysts in IL media for asymmetric Michael addition reactions of ketones and aldehydes to nitro-olefins. Similar or even better conversions and enantioselectivities (ee up to 95%) compared to the original L-proline were achieved. Additionally, a good product extraction performance using supercritical CO2 processes was obtained.
7α and 7β Hydroxylation of Dehydroepiandrosterone by Gibberella sp. and Absidia Coerulea Biotransformation
Authors: Song Ming , Fu Ruicheng , Cai Sulan , Jiang Xuliang , Wang Fuju , Xu Weizhuo , Xu Wei
Published: January 2023

The hydroxylation of dehydroepiandrosterone (DHEA) to 7α -hydroxy-5-androstene-17-one (7α-OH-DHEA) and 7β-hydroxy-5-androstene-17-one (7β-OH-DHEA) by Gibberella sp. CICC 2498 and Absidia coerulea CICC 41050 was investigated. The media ingredients were optimized. Single factors such as the DHEA concentration, culture time, medium volume, and inoculum rate were individually investigated to generate optimum biotransformation conditions. An orthogonal optimization process using a four-factor, three- level L9 (33) experiment was designed and performed. Finally, the maximum production of 7β-OH-DHEA from DHEA biotransformation by Absidia coerulea is 69.61%. This strategy would provide a possible way to enhance the 7β-OH-DHEA yield in the pharmaceutical industry.
Selectivity Control of CO2 Reduction over Pt/g-C3N4 Photocatalysts under Visible Light
Authors: Saraev Andrey A. , Kurenkova Anna Y. , Zhurenok Angelina V. , Gerasimov Evgeny Y. , Kozlova Ekaterina A.
Published: January 2023

Photocatalysts based on g-C3N4 have been investigated in the CO2 reduction reaction under visible light irradiation (λ = 397, 427, 452 nm). Photocatalysts were prepared by melamine calcination at 500–600 °C with further platinum deposition (0.1–1.0 wt.%). The effect of the preparation conditions of g-C3N4 and the method of platinum deposition on the physicochemical properties and activity of photocatalysts was studied. The photocatalysts were investigated by X-ray photoelectron spectroscopy, X-ray absorption spectroscopy, X-ray diffraction, high resolution transmission electron microscopy, UV-Vis spectroscopy, and low temperature nitrogen adsorption techniques. It has been found that the efficiency of CO2 reduction is governed by the surface area of g-C3N4 and the presence of platinum in the metallic state, while the optimal content of platinum is 0.5 wt. %. The highest rate of CO2 reduction achieved over Pt/g-C3N4 photocatalyst is 13.2 µmol h−1 g−1 (397 nm), which exceeds the activity of pristine g-C3N4 by 7 times. The most active photocatalysts was prepared by calcining melamine in air at 600 °C, followed by modification with platinum (0.5 wt.%).
Promises and Challenges of Predictive Blood Biomarkers for Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy
Authors: Machado Carvalho Joao Victor , Dutoit Valérie , Corrò Claudia , Koessler Thibaud
Published: January 2023

The treatment of locally advanced rectal cancer (LARC) requires a multimodal approach combining neoadjuvant radiotherapy or chemoradiotherapy (CRT) and surgery. Predicting tumor response to CRT can guide clinical decision making and improve patient care while avoiding unnecessary toxicity and morbidity. Circulating biomarkers offer both the advantage to be easily accessed and followed over time. In recent years, biomarkers such as proteins, blood cells, or nucleic acids have been investigated for their predictive value in oncology. We conducted a comprehensive literature review with the aim to summarize the status of circulating biomarkers predicting response to CRT in LARC. Forty-nine publications, of which forty-seven full-text articles, one review and one systematic review, were retrieved. These studies evaluated circulating markers (CEA and CA 19-9), inflammatory biomarkers (CRP, albumin, and lymphocytes), hematologic markers (hemoglobin and thrombocytes), lipids and circulating nucleic acids (cell-free DNA [cfDNA], circulating tumor DNA [ctDNA], and microRNA [miRNA]). Post-CRT CEA levels had the most consistent association with tumor response, while cfDNA integrity index, MGMT promoter methylation, ERCC-1, miRNAs, and miRNA-related SNPs were identified as potential predictive markers. Although circulating biomarkers hold great promise, inconsistent results, low statistical power, and low specificity and sensibility prevent them from reliably predicting tumor response following CRT. Validation and standardization of methods and technologies are further required to confirm results.
A Silver Nanoparticles-Based Selective and Sensitive Colorimetric Assay for Ciprofloxacin in Biological, Environmental, and Commercial Samples
Authors: Aijaz Aqsa , Raja Daim Asif , Khan Farooq-Ahmad , Barek Jiri , Malik Muhammad Imran
Published: January 2023

The wide-spread usage of ciprofloxacin (CIP) resulted in its presence in different parts of the ecosystem. Thus, a simple, reliable, on-spot detection method for CIP is required in environmental context. Herein, a colorimetric assay is developed for the detection of CIP based on the branched polyethyleneimine (PEI) conjugated silver nanoparticles (PEI-AgNPs). AgNPs are prepared using PEI as stabilizing agent following a simple one-pot two-phase procedure. The prepared PEI-AgNPs are subsequently used for an efficient and selective detection of CIP. The characteristic yellow colour of PEI-AgNPs changed to colourless when CIP was added which was further confirmed by quenching in the intensity of the SPR (surface plasmon resonance) band (hypochromic shift). The proposed method is efficient for the quantitation of CIP in a linear dynamic range (LDR) of 0.1–200 µM with a limit of detection (LOD) of 0.038 µM, and limit of quantification (LOQ) of 0.12 µM. The developed method is selective, efficient, and sensitive to CIP in the presence of numerous interfering species and in real biological, environmental, and commercial pharmaceutical samples. Excellent performance of the proposed method compared to UV-Vis spectroscopy and UPLC in environmental, biological, and commercial pharmaceutical samples is demonstrated.
Children First, a Debate on the Restrictions to Tackle COVID-19
Authors: Verd Sergio
Published: January 2023

Sometimes, when a public health disaster strikes, mandatory freedom-limiting restrictions must be enforced in order to save lives. During the first waves of the COVID-19 pandemic, the customary and necessary exchange of ideas in academia drastically changed in most countries, and the absence of debate on the restrictions enforced became evident. Now that the pandemic seems to be drawing to an end, the aim of this article is to spark clinical and public debate on the ethical issues concerning pediatric COVID-19 mandates in an attempt to analyze what happened. With theoretical reflection, and not empirical inquiry, we address the mitigation measures which proved detrimental to children despite being beneficial to other segments of the population. We focus on three key points: (i) the sacrifice of fundamental children’s rights for the greater good, (ii) the feasibility of cost–benefit analyses to make public health decisions and restrictions which affect children, and (iii) to analyze the impediments to allowing children’s voices to be heard concerning their medical treatment.
Effects of the Whole-Body Vibration Exercise on Sleep Disorders, Body Temperature, Body Composition, Tone, and Clinical Parameters in a Child with Down Syndrome Who Underwent Total Atrioventricular Septal Defect Surgery: A Case-Report
Authors: Torres-Nunes Luiza , da Costa-Borges Patrícia Prado , Paineiras-Domingos Laisa Liane , Bachur José Alexandre , Coelho-Oliveira Ana Carolina , da Cunha de Sá-Caputo Danúbia , Bernardo-Filho Mario
Published: January 2023

Background: The health and developmental issues of people with Down syndrome (DS) are complex and are associated with many medical, psychological, and social problems from childhood through into adulthood. DS children have an increased risk of multiorgan comorbidities, including congenital heart disease. Atrioventricular septal defect (AVSD) is a congenital heart malformation that often occurs in DS people. Aim: Physical activity and exercise are recommended for patients with cardiovascular disease and are considered to be the gold standard of cardiac rehabilitation. Whole-body vibration exercise (WBVE) is considered a form of exercises. The aim of this case report is to show the effects of WBVE on sleep disturbances, body temperature, body composition, tone, and clinical parameters in a child with DS with corrected total AVSD. The subject is a 10-year-old girl, with free-type DS, who underwent surgery to correct a total AVSD at 6 months. She underwent periodic cardiological monitoring and was released to perform any type of physical exercise, including WBVE. WBVE improved sleep quality and body composition. Conclusion: WBVE leads to physiological effects that benefit the DS child.
Efficiency of the NWC SAF Version 2021 CRRPh Precipitation Product: Comparison against Previous NWC SAF Precipitation Products and the Influence of Topography
Authors: Karagiannidis Athanasios , Lahuerta José Alberto , Calbet Xavier , Lliso Llorenç , Lagouvardos Konstantinos , Kotroni Vassiliki , Ripodas Pilar
Published: January 2023

The algorithm of the Convective Rainfall Rate with Microphysical Properties (CRRPh) product of the 2021 version of the Nowcasting and Very Short Range Forecasting Satellite Application Facility (NWC SAF) presents innovative characteristics. It was developed employing principal components analysis to reduce the number of utilized parameters and uses the same mathematical scheme for day and night, simulating the missing visual channels and satellite-derived cloud water path information that is unavailable during nighttime. Applying adequate statistical methodologies and scores and using rain gauge data as ground truth, it is shown that the new algorithm appears to be significantly improved compared to its predecessors in regard to the delineation of the precipitation areas. In addition, it minimizes the day–night difference in the estimation efficiency, which is a remarkable achievement. The new product suffers from slightly higher errors in the precipitation accumulations. Finally, it is shown that topography does not seem to affect the estimation efficiency of the product. In light of these results, it is argued that, overall, the new algorithm outperforms its predecessors and, possibly after adequate adaptations, can be used as a real-time total precipitation product.
Time-Varying Wear Calculation Method for Fractal Rough Surfaces of Friction Pairs
Authors: Hao Qiang , Yin Jian , Liu Yu , Jin Lu , Zhang Shengfang , Sha Zhihua
Published: January 2023

For the wear problem of the real rough surface during sliding friction, based on fractal theory and Hertz contact theory, a 3-D fractal rough surface with random characteristics is constructed, and the relationship between the wear deformation depth of the rough peak and its real contact area during the wear process is derived. Furthermore, considering the peak wear and pit scratch phenomena of rough surfaces in different contact states, the time-varying wear calculation model of the worn surface and the compensation wear calculation model of the unworn surface are established, respectively, and the relationship between the instantaneous wear amount and the dynamic change in the rough surface topography is comprehensively characterized. Combined with image digitization technology, the 3-D rough surface is converted into a 2-D discrete plane with 3-D information. According to the dynamic real-time update of the graph data, the iterative calculation of the wear cycle is completed, the time-varying wear calculation method for fractal rough surfaces of friction pairs is proposed, and the dynamic change in the wear amount and surface topography of the rough surface is simulated. The simulation results are experimentally verified and the influence of friction parameters on the surface topography is analyzed. The results show that after the wear simulation, the profile height of the rough surface is reduced, and the average wear depth is 0.02 mm. Increases in rotational speeds and external loads can exacerbate surface wear, surface topography tends to be flattened, and surface carrying capacity increases. This provides theoretical guidance for the development and manufacture of friction pairs.
Study of Microstructure Regulation and In Situ Tensile Performance of Ni-Al Films
Authors: Xu Shipeng , Zheng Yuehong , Sheng Jie , Chen Weiqian , Zhan Faqi , La Peiqing
Published: January 2023

In this paper, Ni-Al films were prepared using magnetron sputtering technology. The microstructure of the films and the relationship between the residual stress and the adhesion strength were studied. More importantly, the mechanical strength–ductility properties of Ni-Al films were evaluated by in situ tensile testing. The results showed that the film mainly consisted of Ni3Al phase and Ni-based solid solution at the low power of Al target. The phase transition occurred, and the NiAl phase appeared when the Al sputtering power was increased. The complex structure, with the coexistence of Ni-based solid solution, Ni3Al, and NiAl phases, possessed increased residual stress and reduced adhesion strength. Meanwhile, the crack was easily penetrated through the inside and outside of the film, falling off during in situ tensile testing. While the small residual stress and large adhesion strength were obtained, only Ni3Al and NiAl coexisted, and the film fell off with difficulty. When the Al sputtering power was 400 W, the film showed the largest adhesion strength and the smallest residual stress. The best comprehensive performance was achieved with a tensile strength of 854 MPa and a yield strength of 90 MPa. The Al content of the film was up to 23.03 at.%, which was beneficial to the application and performance improvement of the film in molten salt corrosion resistance.
Classification of Retinal Diseases in Optical Coherence Tomography Images Using Artificial Intelligence and Firefly Algorithm
Authors: Özdaş Mehmet Batuhan , Uysal Fatih , Hardalaç Fırat
Published: January 2023

In recent years, the number of studies for the automatic diagnosis of biomedical diseases has increased. Many of these studies have used Deep Learning, which gives extremely good results but requires a vast amount of data and computing load. If the processor is of insufficient quality, this takes time and places an excessive load on the processor. On the other hand, Machine Learning is faster than Deep Learning and does not have a much-needed computing load, but it does not provide as high an accuracy value as Deep Learning. Therefore, our goal is to develop a hybrid system that provides a high accuracy value, while requiring a smaller computing load and less time to diagnose biomedical diseases such as the retinal diseases we chose for this study. For this purpose, first, retinal layer extraction was conducted through image preprocessing. Then, traditional feature extractors were combined with pre-trained Deep Learning feature extractors. To select the best features, we used the Firefly algorithm. In the end, multiple binary classifications were conducted instead of multiclass classification with Machine Learning classifiers. Two public datasets were used in this study. The first dataset had a mean accuracy of 0.957, and the second dataset had a mean accuracy of 0.954.
Role of Inferior Vena Cava (IVC) Recanalization in Patients with Back Pain, Secondary to IVC Obstruction in Budd–Chiari Syndrome
Authors: Kubihal Vijay , Mukund Amar , Pandey Yasha , Vashistha Chitranshu , Maiwall Rakhi , Patidar Yashwant , Yadav Anil Yogendra , Koul Roshan Lal , Sarin Shiv Kumar
Published: January 2023

Purpose: To study the prevalence of back pain in patients of Budd–Chiari syndrome (BCS) with inferior vena cava (IVC) obstruction, and to evaluate the role of IVC recanalization in resolution of back pain. Methods: All patients with BCS and IVC obstruction who underwent IVC recanalization between January 2018 and October 2022 were included. Patients with degenerative spine disease or other identifiable causes for back pain were excluded; remaining patients were assessed for the presence of back pain. In patients with back pain, pain relief was assessed at 24 h following IVC recanalization. Results: Fifty-eight patients with BCS and IVC occlusion were identified, of which six with degenerative spine diseases were excluded. Of the remaining 52 patients, 34 (65.4%) had back pain, with pain score between 3 and 9. Engorged epidural venous plexus on preprocedural imaging (p = 0.002), and degree of luminal narrowing (p = 0.021) had a significant association with back pain. Twenty-nine of thirty-four patients (85.3%) with back pain had pain relief immediately following IVC recanalization, more so in patients with engorged epidural venous plexus on preprocedural imaging (p < 0.001). Conclusion: Back pain is one of the under-reported symptoms of IVC obstruction in BCS. IVC recanalization by IVC angioplasty with or without stenting relieves back pain due to the decompression of engorged epidural veins.
Uncertain-CAM: Uncertainty-Based Ensemble Machine Voting for Improved COVID-19 CXR Classification and Explainability
Authors: Aldhahi Waleed , Sull Sanghoon
Published: January 2023

The ongoing coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on patients and healthcare systems across the world. Distinguishing non-COVID-19 patients from COVID-19 patients at the lowest possible cost and in the earliest stages of the disease is a major issue. Additionally, the implementation of explainable deep learning decisions is another issue, especially in critical fields such as medicine. The study presents a method to train deep learning models and apply an uncertainty-based ensemble voting policy to achieve 99% accuracy in classifying COVID-19 chest X-rays from normal and pneumonia-related infections. We further present a training scheme that integrates the cyclic cosine annealing approach with cross-validation and uncertainty quantification that is measured using prediction interval coverage probability (PICP) as final ensemble voting weights. We also propose the Uncertain-CAM technique, which improves deep learning explainability and provides a more reliable COVID-19 classification system. We introduce a new image processing technique to measure the explainability based on ground-truth, and we compared it with the widely adopted Grad-CAM method.
The Involvement of Athletes with Intellectual Disability in Community Sports Clubs
Authors: Pochstein Florian , Diaz Garolera Gemma , Menke Sabine , McConkey Roy
Published: January 2023

People with intellectual disability lack opportunities to engage in sports, although the benefits of doing so may be even greater for them. One option is to encourage their inclusion in mainstream sports clubs that exist in nearly all European communities. Although there is a growing knowledge base within organisations such as Special Olympics in adjusting sports to meet the needs of people with intellectual disability, inclusion in community clubs raises additional challenges. This exploratory study aimed to garner the experiences of coaches alongside those of clubs members—with and without disabilities—in 12 community sports clubs in three European countries. In all 20 coaches and 51 members took part in semi-structured interviews. A thematic content analysis was used to devise a conceptual model describing an inclusive sports club. The overarching theme was that inclusive clubs require an ongoing balancing between a focus on sporting skills and performance, with managing the needs and characteristics of the players and the inter-relationships among them. Six subthemes were identified that described the core strategies to the effective functioning of the clubs. However, the vision and commitment of coaches was crucial and their recruitment was the main challenge the clubs faced. In addition, new opportunities for training coaches are needed to support the extension of inclusive clubs across a range of sports and locations. Continuing research could usefully identify the benefits to club members and identify sport-specific adaptations required to make clubs more fully inclusive.
Diagnostic Biomarkers for Gestational Diabetes Mellitus Using Spectroscopy Techniques: A Systematic Review
Authors: Khan Rabia Sannam , Malik Haroon
Published: January 2023

Gestational diabetes mellitus (GDM) is associated with adverse maternal and foetal consequences, along with the subsequent risk of type 2 diabetes mellitus (T2DM) and several other diseases. Due to early risk stratification in the prevention of progression of GDM, improvements in biomarker determination for GDM diagnosis will enhance the optimization of both maternal and foetal health. Spectroscopy techniques are being used in an increasing number of applications in medicine for investigating biochemical pathways and the identification of key biomarkers associated with the pathogenesis of GDM. The significance of spectroscopy promises the molecular information without the need for special stains and dyes; therefore, it speeds up and simplifies the necessary ex vivo and in vivo analysis for interventions in healthcare. All the selected studies showed that spectroscopy techniques were effective in the identification of biomarkers through specific biofluids. Existing GDM prediction and diagnosis through spectroscopy techniques presented invariable findings. Further studies are required in larger, ethnically diverse populations. This systematic review provides the up-to-date state of research on biomarkers in GDM, which were identified via various spectroscopy techniques, and a discussion of the clinical significance of these biomarkers in the prediction, diagnosis, and management of GDM.
A Maturity Matrix Model to Strengthen the Quality Cultures in Higher Education
Authors: Verschueren Niki , Van Dessel Jolien , Verslyppe Andries , Schoensetters Yannick , Baelmans Martine
Published: January 2023

This article approaches quality assurance in higher education from the perspective of quality culture. We present a concept model of quality culture that incorporates both the structural/managerial elements of the educational context as well as individual and interpersonal dynamics. The model highlights the importance of leadership, communication and information in connecting both sides of the educational praice. Our approach is unique in that it provides an interactive instrument to map, discuss and advance the existing quality cultures in cocreation with the educational actors. This instrument consists of a face-valid blueprint of the concept of quality culture. This blueprint is enriched by identifying the characteristics for less and more mature quality cultures. The feasibility of the instrument was tested in a pilot study with 13 appreciative in-depth interviews. We found that this instrument allowed faculty members and programme directors to grasp and co-create the profile of their existing quality culture. By using the appreciative approach, stimulating dialogue and reflection, our concept of quality culture aims to structure, scaffold and strengthen the continuous strive for educational quality.
The Effectiveness of an Online Language Course during the COVID-19 Pandemic: Students’ Perceptions and Hard Evidence
Authors: Shcherbakova Irina O. , Kucherenko Svetlana N. , Smolskaia Natalia B.
Published: January 2023

The aim of this study is to analyse the delivery of an online English language course taught at the Admiral Makarov State University of Maritime and Inland Shipping during the COVID-19 pandemic with the ultimate purpose of identifying those features which could be applied to a prospective blended English as a foreign language (EFL) course in the future. The rationale behind this research is a necessity to redesign the existing language education programme at the University which is outdated and far from being digital. By applying the Mashaw model of evaluating the effectiveness of an online course, the authors analyse the results of the survey carried out among a focus group of 22 students from the radio engineering department of the Admiral Makarov State University of Maritime and Inland Shipping. In the end, the authors identify the points for further consideration in the process of developing a prospective blended EFL course.
A Bibliometric Analysis of Synchronous Computer-Mediated Communication in Language Learning Using VOSviewer and CitNetExplorer
Authors: Hou Yukun , Yu Zhonggen
Published: January 2023

Synchronous computer-mediated communication in the online language classroom has gained growing attention in the wake of the worldwide epidemic. Nevertheless, only a few researchers have studied it through bibliometric analyses. This study aimed to retrospect the previous development and figure out the role of intercultural competence, social presence, and corrective feedback in synchronous computer-mediated communication-based language learning. Both quantitative and qualitative methods were employed to analyze previous studies (n = 1292) by VOSviewer and CitNetExplorer. The findings revealed prolific authors, sources, organizations, and regions in tables, which indicated that scholars in this field were mainly located in the USA and China. With a rising research tendency, several heated topics were also presented with VOSviewer. The findings also signified that intercultural competence, social presence, and corrective feedback all played an important role in synchronous computer-mediated communication-based language learning and they were interdependent. Implications for future studies were also discussed.
A Control of a z-Axis Rotation-Tolerant Wireless Power Transfer System Using a Double DD Coil
Authors: Domajnko Jure , Prosen Nataša
Published: January 2023

This paper describes the control of a wireless power transfer system using a double DD coil structure, when the transmitter and the receiver coil are rotated to one another. WPT systems using single DD coils are rotationally dependent, due to the directional magnetic field generated by the DD transmitter coil. This rotational dependance can be mitigated by using a different transmitter structure. One such possibility is the usage of the double DD coil on the transmitter and the receiver sides. A double DD coil includes two directional DD coils, which can be excited separately. The coils inside the coil structure are perpendicular to one another, which allows higher power density and additional rotation tolerance. The proposed system was tested on a low power laboratory experimental setup.
Investigation of the Ozonation of Highly PAXHs Contaminated Soil Using Ultrahigh Resolution Mass Spectrometry
Authors: Satilmis Ilker , Schrader Wolfgang
Published: January 2023

Ozonation is an effective chemical treatment technique for removing contamination from the environment. In some countries it is used to clean up drinking water instead of using chlorinated treatment. The contamination of soil with polyaromatic compounds (PAXHs with X = N, S or O) are some almost forgotten contaminants but describe very toxic and by now almost omnipresent chemical contaminations. The extremely high number of different PAXHs are strongly adsorbed on soil and a method is introduced where an organic solvent is used to facilitate the reaction of the contaminant with ozone. In this study ozone is applied for 6 or 18 h with addition of toluene and the different phases (organic, water, and extract of soil phase) are studied to understand the ozonolysis of polycyclic aromatic hydrocarbons and their derivatives. The reaction is studied using ultrahigh resolution mass spectrometry (UHRMS) allowing a comprehensive characterization of the initial contaminants as well as the various oxidation products. The results show that the ozonation treatment leads to continuous degradation of already oxidized compounds and a wide range of oxidation products can be detected.
Dynamics of Nonmagnetic and Magnetic Emulsions in Microchannels of Various Materials
Authors: Kalyuzhnaya Dariya , Sokolov Evgeniy , Vasilyeva Anastasia , Sutarina Irina , Ryapolov Petr
Published: January 2023

The formation of droplets in microchannels (droplet microfluidics) has a large number of applications, such as in micro-dosing and gas meters. This paper considers the dynamics of direct and inverse emulsions based on water, polydimethylsiloxane, and synthetic and mineral oil in microfluidic chips based on two technologies: glass–parafilm–glass sandwich structures and removable scaffold in a silicone compound. It is shown that wettability, roughness and chip wall material; channel thickness; magnetic fluid flow rate; and magnetic field strength affect the size of emulsion droplets formed in a microfluidic chip. The addition of another mechanism for regulating the hydrodynamics of emulsions using a magnetic field opens up new possibilities for the development of promising devices.
Providing New Insights on the Molecular Properties and Thermal Stability of Ovotransferrin and Lactoferrin
Authors: Zeng Qi , Liu Yaping , Sun Jing , Jin Yongguo
Published: January 2023

Ovotransferrin (OVT) is a multi-functional protein showing over 50% homology with Bovine lactoferrin (BLF) and human lactoferrin (HLF), which have the potential to be a substitute for lactoferrin (LF) due to the limited production of LF. To explore the substitutability of OVT, the molecular properties and thermal stability of OVT, BLF and HLF were characterized because these properties will affect the processing quality and biological activities of protein products when exposed to different processing conditions (e.g., temperature, pH, ion strength). The results showed that although obviously different isoelectric point (5.31, 9.12 and 8.75 for OVT, BLF and HLF, respectively), particle size distribution and hydrophobicity were found, they exhibited good dispersity because of high potential value. They showed an endothermic peak at 80.64 °C, 65.71 °C and 90.01 °C, respectively, and the denaturation temperature varied at different pH and ionic strength. OVT and BLF were more susceptible to heating at pH 5.0 as reflected by the decline of denaturation temperature (21.78 °C shift for OVT and 5.81 °C shift for BLF), while HLF could remain stable. Compared with BLF, OVT showed higher secondary structure stability at pH 7.0 and 9.0 with heating. For example, the α-helix content of OVT changed from 20.35% to 15.4% at pH 7.0 after heating, while that of BLF changed from 20.05% to 6.65%. The increase on fluorescence intensity and redshifts on the maximum wavelength after heating indicated the changes of tertiary structure of them. The turbidity measurements showed that the thermal aggregation degree of OVT was lower than BLF and HLF at pH 7.0 (30.98%, 59.53% and 35.66%, respectively) and pH 9.0 (4.83%, 12.80% and 39.87%, respectively). This work demonstrated the similar molecular properties and comparable thermal stability of OVT to BLF and HLF, which can offer a useful reference for the substitute of LF by OVT.
Impacts of Climate Change on Rice Grain: A Literature Review on What Is Happening, and How Should We Proceed?
Authors: Tang Ling , Wu Aoqi , Li Shenshen , Tuerdimaimaiti Mairemu , Zhang Guoyou
Published: January 2023

More than half of the people on Earth get their calories, proteins, and minerals from rice grains. Staple increases in the quantity and quality of rice grains are key to ending hunger and malnutrition. Rice production, however, is vulnerable to climate change, and the climate on Earth is becoming more fluctuating with the atmospheric change induced by human activities. As a result, the impacts of climate change on rice grain (ICCRG) have sparked widespread concern. In order to reveal the development and the trend in the study on the ICCRG, a bibliometric analysis was conducted. The results showed that both the model simulations and the field experiment-based observations, as reflected by APSIM (the Agricultural Production Systems sIMulator) and free-air carbon dioxide (CO2) enrichment, are of concern to researchers worldwide, especially in China, India, the United States, and Japan. Different types of warming include short-term, nighttime, soil and water, and canopy, and their interactions with other climate factors, such as CO2, or agronomic factors, such as nitrogen level, are also of concern to researchers. Spatiotemporal variations in changing weather and regional adaptations from developed and developing countries are challenging the evaluation of ICCRG from an economic perspective. In order to improve the efficacy of breeding adaptable cultivars and developing agronomic management, interdisciplinary studies integrating molecular biology, plant physiology, agronomy, food chemistry, ecology, and socioeconomics are needed.
Gender-Disaggregated Consumer Testing and Descriptive Sensory Analysis of Local and New Yam Varieties
Authors: Effah-Manu Liticia , Wireko-Manu Faustina D. , Agbenorhevi Jacob K. , Maziya-Dixon Busie , Oduro Ibok N.
Published: January 2023

Gender-disaggregated sensory evaluation has become an essential element that could enhance breeding activities by increasing the adoption of new varieties. The effect of age, sex and geographical location on descriptor preferences for boiled and pounded yam were studied using descriptive and consumer testing. Attributes with definitions and measurement scales were used to generate lexicons for boiled and pounded yam. Analytical tools employed for the inferential statistics were the independent t-test, analysis of variance, Kruskal–Wallis test, Mann–Whitney test and relative importance index (RII). Descriptive testing showed that all the D. rotundata varieties were good for boiling and pounding. The D. alata varieties afase soanyinto and afase biri were most liked, while afase pa and ahodenfo were disliked. Age had no significant effect on descriptor preferences. Being a female or male, however, influenced preferences for pounded yam descriptors such as mouldability, lumpiness and colour. The RII for the D. rotundata varieties (0.22–0.28) showed that they are all good varieties for boiling and pounding. The local D. alata varieties were still highly acceptable compared the new CRI varieties due to the aroma. Rural consumers preferred all the descriptors of boiled D. rotundata than urban consumers, whereas urban consumers liked the pounded yam varieties better than the rural consumers. Availability of the new yam varieties on local markets could therefore increase consumption and improve adoption.
Earthquake-Induced Tsunamis in Western Greece (Ionian Sea and Western and Southern Peloponnese): Use of Tsunami Quantities, Impact and ITIS-2012 Intensities for Highlighting Susceptible Areas
Authors: Mavroulis Spyridon , Gogou Marilia , Lekkas Efthymios
Published: January 2023

Taking into account recent studies on the tsunamigenic potential of strike-slip faults, it is concluded that there is a need to reassess their near-source tsunami hazard and risk. One of the areas which needs reassessment is Western Greece, especially the Ionian Islands and the western coastal Peloponnese, where major seismogenic strike-slip structures occur. In this context, an extensive review of the available literature is conducted, including not only earthquake and tsunami catalogues but also tsunamis’ imprints on the stratigraphic record. It is concluded that the Ionian Islands and the western Peloponnese have a rich history of tsunamis since 6000 BC, revealing that they are subjected to high tsunami hazard. In addition to the teletsunami effects of distant earthquakes, there are also local tsunamis with smaller physical quantities and slighter coastal impact that are attributed mainly to local offshore faults and earthquake-triggered landslides. The fact that no destructive local tsunamis have been detected so far does not exclude the possibility of future triggering. In order to identify areas susceptible to future tsunami impact, we extract tsunami quantities and coastal impact data from available sources and we apply the Integrated Tsunami Intensity Scale 2012 (ITIS-2012) for all the events with available and adequate information. The highly susceptible areas comprise straits, funnel-shaped bays and extensive coastal areas exposed to major strike-slip seismogenic sources in the Ionian Sea and the western Hellenic Trench. Based on the aforementioned information, the inclusion of the Ionian Sea in the tsunamigenic zones of Greece is strongly recommended.