bluuebunny/crossref_metadata_2025 huggingface dataset:
The Case of the Peculiar Story: Medical Investigation and the Detective in Edgar Allan Poe and Marguerite Duras
Authors: Filippaki Iro , Krishnan Lakshmi
Published: November 2023

Abstract: In "The Murders in the Rue Morgue" (1841), Poe invents the detective story in English, introducing his gentleman sleuth Auguste Dupin as he solves the locked-room mystery of two women found brutally murdered in a Paris apartment. In L'Amante Anglaise (1967), Duras revisits the detective form, fictionalizing the true 1949 crime of a woman murdering and dismembering her cousin in Viorne, France. These literary detective stories highlight the powerful but unspoken role of affective experience in driving what appears, on the surface, to be a forensic medical or psychological investigation. In both tales, peculiarity is an affective and cognitive force that, contrary to what the majority of affect literature argues, inherently moves toward resolution and closure. Using peculiarity as an analytical concept, we argue that the concealment / discovery binary must acknowledge its affective origins, breaking a barrier between narrative scholarship and medical practice.
Development of an all-solid-state air-cooled high-power blue diode laser for metal processing
Authors: Devara Jayant S. , Jakhar Sandeep , Sihag Yateendra , Panda Biswajit , Venkatesan Ananth , Singh Kamal P.
Published: November 2023

We present the design and development of an all-solid-state
(fluid/refrigerant-free) 100 W scale blue-laser system and show its
applications in precision copper works. We combine powerful
laser-diode arrays with Peltier chips on a compact laser head to
achieve stable thermal and optical performance. Good agreement between
the thermal simulation of the 3D laser head and experiments validates
stable thermal performance. The laser system emits 40–100 W
continuous wave at λ = 452.2 ± 2.5 nm
with 98% power stability and ∼24% wall-plug efficiency inside a
portable enclosure. This is the first, to the best of our knowledge,
all-solid-state air-cooled laser with a 100 W class output. We
achieved kW/cm2 intensity level on an mm-size focus with
this source and demonstrated cutting, bending, and soldering copper on
a battery pack. Furthermore, the copper–solder joints have nanoscale
adhesion without cracks. Additionally, we unveil that 0.5–4
kW/cm2 intensity laser annealing scan makes copper strips
mechanically resilient to withstand extreme loading cycles without
nanoscale cracks.
Electro-optic properties of liquid crystal cells with nanowall electrodes
Authors: Chiang Yu-Chih , Suryantari Risti , Lin Shih-Hung , Silalahi Harry Miyosi , Chiang Wei-Fan , Shih Yi-Hong , Choi Wing-Kit , Huang Chia-Yi
Published: November 2023

This work fabricates a nanowall electrode for achieving advanced liquid crystal (LC) devices and improving LC displays. The nanowall electrode consists of indium–tin–oxide (ITO) sheets stacked with nanowalls, and the nanowalls have a height and thickness of 4 µm and 500 nm, respectively. The high aspect ratio (8.0) of the nanowalls sets the nanowall electrode apart from previous electrodes. A flat electrode that comprises only ITO sheets is used to evaluate the nanowall electrode. The LC cell with the nanowall electrode exhibits better electro-optic properties than the LC cell with the flat electrode due to the strong transverse electric field and small subelectrode gap of the nanowall electrode. Especially, the operating voltage (3.7 V) of the nanowall cell is 36% smaller than that (5.8 V) of the flat cell. Therefore, nanowall electrodes have potential in LC lenses, LC antennas, metaverse displays, and digital optics.
Optical and electrical characteristics of perovskite solar cells incorporating MoO3 as an active layer
Authors: Gehlot Himanshu , Faujdar Manu , Pokhriyal Sumit , Khatri Narendra , Sharma Awanish K.
Published: November 2023

Perovskite-based solar cell technologies have sparked much interest in recent decades. A solar cell’s efficiency is an essential factor in developing a highly efficient device. The power conversion efficiency (PCE) of Perovskite-based solar cells can be enhanced by adding new materials to the photon-absorbing layer and altering the electron and hole transport layers. Titanium dioxide (TiO2) is commonly used in electron transport layers (ETLs), but it has been shown that replacing TiO2 with molybdenum trioxide (MoO3) improves PCE. We use the OghmaNano software to simulate a perovskite-based solar cell and investigate the PCE for TiO2 and MoO3 ETL layers by altering their thickness. The influence of electron and hole drift diffusion, carrier continuity equations in the position space to describe charge flow within the device, Poisson’s equation, and charge carrier recombination have all been investigated in the context of solar cell simulation. It was observed that by substituting the ETL layer of TiO2 with MoO3 in the device, the PCE significantly increases.
Ultraviolet sensing based on an in-fiber ZnO microwire constructed Mach–Zehnder interferometer
Authors: Chen Chen , Wang Ying , Liu Han , Deng Yubin , Wu Xun , Liao Changrui , Weng Xiaoyu , Liu Liwei , Qu Junle , Wang Yiping
Published: November 2023

We propose a Mach–Zehnder interferometer based on an in-fiber ZnO microwire structure for ultraviolet sensing. The device undergoes femtosecond laser micromachining and chemical etching on a single-mode optical fiber initially, creating a microgroove that extends to half of the core’s depth, into which a single ZnO microwire is transferred. The ZnO microwire and the remaining core are used as the sensing arm and the reference arm, respectively, forming a Mach–Zehnder interferometer. To enhance the stability and the sensitivity, ZnO nanoparticles are filled into the microgroove after the ZnO microwire is transferred. The fabricated device exhibits a sensitivity of 0.86 nm/(W·cm−2) for ultraviolet sensing, along with a response time of 115 ns (rise time) and 133 µs (decay time), respectively. The proposed sensor exhibits good ultraviolet sensitivity, offering a novel approach for ultraviolet sensing technology.
Mode-locking of a Tm,Ho:CALYGO laser delivering 50 fs pulses at 2.08 µm
Authors: Ding Heng , Liu Jian , Wang Yinyin , Zhang Ning , Wang Zhanxin , Zhao Yongguang , Xu Xiaodong , Xue Yanyan , Xu Jun , Griebner Uwe , Petrov Valentin
Published: November 2023

We study the polarization-dependent laser performance of a novel, to the best of our knowledge, “mixed” Tm,Ho:CaYGdAlO4 crystal in the continuous-wave (CW) and mode-locked regimes. Both in terms of the CW tunability range (261 nm) and the minimum pulse duration (50 fs at 2078 nm, spectral width of 95 nm) in the mode-locked regime, σ-polarization is superior. With extended inhomogeneous spectral broadening due to structural and compositional disorder, Tm,Ho:CaYGdAlO4 is promising for few-optical-cycle pulse generation around 2 µm.
Nonsense mutation suppression is enhanced by targeting different stages of the protein synthesis process
Authors: Wittenstein Amnon , Caspi Michal , Rippin Ido , Elroy-Stein Orna , Eldar-Finkelman Hagit , Thoms Sven , Rosin-Arbesfeld Rina
Published: November 2023

The introduction of premature termination codons (PTCs), as a result of splicing defects, insertions, deletions, or point mutations (also termed nonsense mutations), lead to numerous genetic diseases, ranging from rare neuro-metabolic disorders to relatively common inheritable cancer syndromes and muscular dystrophies. Over the years, a large number of studies have demonstrated that certain antibiotics and other synthetic molecules can act as PTC suppressors by inducing readthrough of nonsense mutations, thereby restoring the expression of full-length proteins. Unfortunately, most PTC readthrough-inducing agents are toxic, have limited effects, and cannot be used for therapeutic purposes. Thus, further efforts are required to improve the clinical outcome of nonsense mutation suppressors. Here, by focusing on enhancing readthrough of pathogenic nonsense mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, we show that disturbing the protein translation initiation complex, as well as targeting other stages of the protein translation machinery, enhances both antibiotic and non-antibiotic-mediated readthrough of nonsense mutations. These findings strongly increase our understanding of the mechanisms involved in nonsense mutation readthrough and facilitate the development of novel therapeutic targets for nonsense suppression to restore protein expression from a large variety of disease-causing mutated transcripts.
Intrinsically disordered regions are not sufficient to direct the compartmental localization of nucleolar proteins in the nucleus
Authors: Lavering Emily D. , Gandhamaneni Maunika , Weeks Daniel L.
Published: November 2023

The nucleolus is a non-membrane bound organelle central to ribosome biogenesis. The nucleolus contains a mix of proteins and RNA and has 3 known nucleolar compartments: the fibrillar center (FC), the dense fibrillar component (DFC), and the granular component (GC). The spatial organization of the nucleolus is influenced by the phase separation properties of nucleolar proteins, the presence of RNA, protein modification, and cellular activity. Many nucleolar proteins appear to concentrate within the borders of the compartments. We investigated whether the intrinsically disordered regions from several proteins provided the information needed to establish specific compartment localization using Xenopus laevis oocytes. For the proteins we tested, the disordered regions were not sufficient to direct specific domain localization and appear dispensable with respect to compartmentalization. Among the proteins that colocalize to the DFC are the quartet that comprise the box H/ACA pseudouridylation complex. In contrast to the insufficiency of IDRs to direct compartment localization, we found that the DFC accumulation of 2 box H/ACA proteins, Gar1 and Nhp2, was disrupted by mutations that were previously shown to reduce their ability to join the box H/ACA complex. Using a nanobody to introduce novel binding to a different DFC localized protein, we restored the localization of the mutated forms of Gar1 and Nhp2.
Ten simple rules for students navigating summer research experiences for undergraduates (REU) programs: From application to program completion
Authors: Manzanares Maria , Peña Courtney , Kobak Kayla C. , Stratton Miranda B.
Published: November 2023

For many emerging scientists, research experiences for undergraduates (REU) programs are an important gateway to graduate school and a career in science, technology, engineering, and mathematics (STEM). REUs provide guided mentorship and learning experiences in a summer-long program where students develop research skills, build scientific knowledge, and strengthen their scientific identity. While the benefits of REUs are abundant, the process is not always easy to navigate, especially for students who come from first-generation and/or low-income (FLI) backgrounds. This paper provides two-fold guidance for undergraduate students interested in participating in REUs. Rules 1 to 5 focus on demystifying the application process from beginning to end, and Rules 6 to 10 guide students who are on the other side of the application process. Thus, this paper will be most helpful for undergraduate students who are either considering applying for an REU or have been accepted into one and want to learn more about what to expect. It can also be a shareable resource for faculty, staff, and mentors who work directly with STEM undergraduates.
Prevalence and clinical characteristics of increased pancreatic enzymes in patients with severe fever with thrombocytopenia syndrome
Authors: Zhang Zhongwei , Hu Xue , Jiang Qunqun , Du Qian , Liu Jie , Luo Mingqi , Deng Liping , Xiong Yong
Published: November 2023

Background and aim

The increased pancreatic enzymes have recently been reported in patients with severe fever with thrombocytopenia syndrome (SFTS). However, its significance has not been elucidated clearly. The aim of this study was to explore the prevalence, clinical characteristics of elevated pancreatic enzymes (amylase and lipase) and its association with AP in patients with SFTS.

Methods

Data of demographics, comorbid conditions, clinical symptoms, laboratory parameters and survival time of patients with SFTS were collected. Patients were assigned into the non-AP and AP groups according to the diagnostic criteria of AP. Patients in the non-AP group were divided into the normal (3×ULN) groups according to the serum amylase and lipase levels, and then their clinical data were compared.

Results

A total of 284 patients diagnosed with SFTS were retrospectively enrolled, including 248 patients in the non-AP group and 36 patients in the AP group. Patients in the non-AP group were composed of 48, 116 and 84 patients in the normal, EPE and HPE groups, respectively. Compared with patients in the normal and EPE groups, patients in the HPE group had higher serum levels of laboratory parameters referring to liver, kidney, heart and coagulation system injury, as well as higher viral load. The cumulative survival rate of patients in the HPE group was significantly lower than that of patients in the normal group. In addition, patients in the AP group also had higher serum levels of laboratory variables reflecting liver, heart, coagulation dysfunction and viral load than patients in the HPE group. The cumulative survival rate of patients in the AP group was significantly lower than that of patients in the HPE group.

Conclusion

The increased pancreatic enzymes are very common in patients with SFTS, but they are not always associated with AP. Though AP accounts for the majority of deaths for patients with elevated pancreatic enzymes, patients with pancreatic enzymes >3×ULN except for AP also have a high in-hospital mortality rate.
Advances in sparse dynamic scanning in spectromicroscopy through compressive sensing
Authors: Kourousias George , Billè Fulvio , Guzzi Francesco , Ippoliti Matteo , Bonanni Valentina , Gianoncelli Alessandra
Published: November 2023

Scanning microscopies and spectroscopies like X-ray Fluorescence (XRF), Scanning Transmission X-ray Microscopy (STXM), and Ptychography are of very high scientific importance as they can be employed in several research fields. Methodology and technology advances aim at analysing larger samples at better resolutions, improved sensitivities and higher acquisition speeds. The frontiers of those advances are in detectors, radiation sources, motors, but also in acquisition and analysis software together with general methodology improvements. We have recently introduced and fully implemented an intelligent scanning methodology based on compressive sensing, on a soft X-ray microscopy beamline. This demonstrated sparse low energy XRF scanning of dynamically chosen regions of interest in combination with STXM, yielding spectroimaging data in the megapixel-range and in shorter timeframes than were previously not feasible. This research has been further developed and has been applied to scientific applications in biology. The developments are mostly in the dynamic triggering decisional mechanism in order to incorporate modern Machine Learning (ML) but also in the suitable integration of the method in the control system, making it available for other beamlines and imaging techniques. On the applications front, the method was previously successfully used on different samples, from lung and ovarian human tissues to plant root sections. This manuscript introduces the latest methodology advances and demonstrates their applications in life and environmental sciences. Lastly, it highlights the auxiliary development of a mobile application, designed to assist the user in the selection of specific regions of interest in an easy way.
A stochastic programming approach to perform hospital capacity assessments
Authors: Burdett Robert L. , Corry Paul , Spratt Belinda , Cook David , Yarlagadda Prasad
Published: November 2023

This article introduces a bespoke risk averse stochastic programming approach for performing a strategic level assessment of hospital capacity (QAHC). We include stochastic treatment durations and length of stay in the analysis for the first time. To the best of our knowledge this is a new capability, not yet provided in the literature. Our stochastic programming approach identifies the maximum caseload that can be treated over a specified duration of time subject to a specified risk threshold in relation to temporary exceedances of capacity. Sample averaging techniques are applied to handle probabilistic constraints, but due to the size and complexity of the resultant mixed integer programming model, a novel two-stage hierarchical solution approach is needed. Our two-stage hierarchical solution approach is novel as it combines the application of a meta-heuristic with a binary search. It is also computationally fast. A case study of a large public hospital has been considered and extensive numerical tests have been undertaken to highlight the nuances and intricacies of the analysis. We conclude that the proposed approach is effective and can provide extra clarity and insights around hospital outputs. It provides a way to better calibrate hospitals and other health care infrastructure to future demands and challenges, like those created by the COVID pandemic.
Association between hearing loss and cognitive decline in the elderly: A systematic review with meta-analysis study
Authors: Conceição Santos de Oliveira Débora , Gomes-Filho Isaac Suzart , Araújo Edna Maria , Xavier Ramos Michelle de Santana , Freitas Coelho Julita Maria , Marques Adan Araújo , Hintz Alexandre Marcelo , Firmino Rabelo Dóris , Figueiredo Ana Claudia Morais Godoy , da Cruz Simone Seixas
Published: November 2023

Objective

Hearing loss has been pointed out as a potential predictor for cognitive decline. This study conducted a systematic review to evaluate the scientific evidence on the association between hearing loss in the elderly and cognitive decline, as well as whether race/color influences this relationship.

Method

The search for studies was performed in the following electronic databases: MedLine/PubMed Web of Science, Scopus and Virtual Health Library, and MedRkiv up to August 2022. Studies with epidemiological designs that assess the association between hearing loss and cognitive decline in the elderly were eligible for inclusion. Three independent reviewers performed the selection, data extraction and evaluation of the quality of the studies using the Newcastle-Ottawa Scale. A meta-analysis using a random effects model estimated the global association measurements (Beta coefficient: β) and their 95% confidence intervals (95%CI), and the Higgins and Thompson indicator (I2) was also estimated to assess statistical heterogeneity among the studies.

Results

5,207 records were identified in the database surveys, of which only 18 were eligible studies, totaling 19,551 individuals. Hearing loss was associated with cognitive decline in the elderly, with statistical significance: β = -0.13; 95%CI = -0.23 to -0.04; I2 = 98.70%). For black individuals, the magnitude of the association increased: β = -0.64; 95%CI = -3.36 to 2.07; I2 = 95.65%, but it was not statistically significant.

Conclusion

The findings of this systematic review showed the existence of a significant relationship between hearing loss and cognitive decline in the elderly, as well as signaling that among black individuals the magnitude of the association can be increased.
Does green innovation moderate between FDI and environmental sustainability? Empirical evidence from South Asia
Authors: Brohi Awais Ahmed , Suzuki Yoshihisa
Published: November 2023

The study aims to investigate how foreign direct investment (FDI) and green innovation (GI) impact environmental quality in South Asia. Moreover, this study examines the moderating role of GI between FDI and environmental sustainability. We use panel data from 1995 to 2018 for five South Asian nations namely, Pakistan, India, Bangladesh, Sri Lanka, and Nepal. For the empirical analysis, we used 1st generation cointegration like Pedroni and Kao, and 2nd generation cointegration tests like Westerlund. Moreover, for the long-run relationship, we employ fully modified least squares (FMOLS) and dynamic ordinary least squares (DOLS) estimation. The study’s empirical results suggest that GI significantly enhances ecological sustainability in South Asian economies; however, FDI degrades the environmental quality. Furthermore, the results suggest that GI significantly moderates the nexus of FDI and ecological sustainability in South Asia. It is recommended that South Asian countries increase green innovation with FDI so that environmental quality can be assured for the region’s sustainable development.
Potential contribution of PrEP uptake by adolescents 15–17 years old to achieving the “Ending the HIV Epidemic” incidence reduction goals in the US South
Authors: Hamilton Deven T. , Wang Li Yan , Hoover Karen W. , Smith Dawn K. , Delaney Kevin P. , Li Jingjing , Hoyte Tamika , Jenness Samuel M. , Goodreau Steven M.
Published: November 2023

Background

The “Ending the HIV Epidemic” (EHE) initiative seeks to reduce new HIV infections in the U.S. by prioritizing federal resources towards highly impacted populations. Antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are essential for reaching EHE goals. Adolescents are often at increased risk for HIV because they may lack agency in negotiating their sexual partnerships and may not have the same access to treatment and prevention as adults. This study estimates the potential contribution of expanded PrEP coverage among adolescents ages 15–17 to achieving the EHE goals in the South.

Methods

An HIV-transmission model was built to simulate the HIV epidemic in the South. Increased ART and PrEP uptake were systematically varied with and without PrEP eligibility including individuals age<18.

Results

Prioritizing PrEP for adolescents had a negligible impact on incidence. At 50% uptake among eligible adolescents and 90% ART coverage, including adolescents only improved the percentage of infections averted from 80.1% to 80.3%. In 10 of 15 scenarios explored, there was no reduction in new infections when PrEP eligibility was expanded to include adolescents age<18. At 95% ART coverage at the population-level incidence among adolescents declined by over 80%, but PrEP uptake among adolescents did not contribute to additional declines in incidence among adolescents.

Conclusions

Prioritizing PrEP for adolescents did not significantly contribute to reaching EHE incidence reductions goal. Focusing resources to specific adolescent populations at risk, such sexual minority males in high incidence settings, will remain an important public health goal outside the context of EHE.
Using cellular device location data to estimate visitation to public lands: Comparing device location data to U.S. National Park Service’s visitor use statistics
Authors: Tsai Wei-Lun , Merrill Nathaniel H. , Neale Anne C. , Grupper Madeline
Published: November 2023

Understanding human use of public lands is essential for management of natural and cultural resources. However, compiling consistently reliable visitation data across large spatial and temporal scales and across different land managing entities is challenging. Cellular device locations have been demonstrated as a source to map human activity patterns and may offer a viable solution to overcome some of the challenges that traditional on-the-ground visitation counts face on public lands. Yet, large-scale applicability of human mobility data derived from cell phone device locations for estimating visitation counts to public lands remains unclear. This study aims to address this knowledge gap by examining the efficacy and limitations of using commercially available cellular data to estimate visitation to public lands. We used the United States’ National Park Service’s (NPS) 2018 and 2019 monthly visitor use counts as a ground-truth and developed visitation models using cellular device location-derived monthly visitor counts as a predictor variable. Other covariates, including park unit type, porousness, and park setting (i.e., urban vs. non-urban, iconic vs. local), were included in the model to examine the impact of park attributes on the relationship between NPS and cell phone-derived counts. We applied Pearson’s correlation and generalized linear mixed model with adjustment of month and accounting for potential clustering by the individual park units to evaluate the reliability of using cell data to estimate visitation counts. Of the 38 parks in our study, 20 parks had a correlation of greater than 0.8 between monthly NPS and cell data counts and 8 parks had a correlation of less than 0.5. Regression modeling showed that the cell data could explain a great amount of the variability (conditional R-squared = 0.96) of NPS counts. However, these relationships varied across parks, with better associations generally observed for iconic parks. While our study increased our confidence in using cell phone data to estimate visitation, we also became aware of some of the limitations and challenges which we present in the Discussion.
On distance-based topological indices and co-indices of fractal-type molecular graphs and their respective graph entropies
Authors: Malik Mehar Ali , Imran Muhammad , Adeel Muhammad
Published: November 2023

In graph theory, a topological index is a numerical value that is in good correlation with certain physical properties of a molecule. It serves as an indicator of how a chemical structure behaves. The Shannon’s entropy describes a comparable loss of data in information transmission networks. It has found use in the field of information theory. Inspired by the concept of Shannon’s entropy, we have calculated some topological descriptors for fractal and Cayley-type dendrimer trees. We also find the entropy that is predicted by these indices.
Clinical profile, prognosis and post COVID-19 syndrome among UNRWA staff in Jordan: A clinical case-series study
Authors: Aldahleh Haneen , Batieha Anwar , Elayyan Rasheed , Abdo Nour , Abuzayed Ishtaiwi , Albaik Shatha , Shahin Yousef , Seita Akihiro
Published: November 2023

Background

The clinical manifestations of Corona Virus Disease of 2019 (COVID-19) varied from patient to patient with evidence of multi-organ involvement. Many patients continue to have a wide range of symptoms for variable periods of time. The long-term effects of COVID-19 infection (post COVID-19 illness or syndrome) are not yet fully explored. This study aims to shed light on the clinical manifestations of the acute COVID-19 infection as well as post COVID-19 syndrome among the United Nations Relief and Works Agency for Palestine Refugee (UNRWA) staff in Jordan.

Methods

A clinical case-series was conducted on a sample of COVID-19 positive employees of the UNRWA staff in Jordan. A structured questionnaire based mainly on World Health Organization (WHO) Case Report Form (CRF) verified tool for post COVID-19 was used. A sample of 366 out of a total of 1322 confirmed cases was systemically selected and included in the present study. Data were collected from UNRWA medical records and phone interviews. Data were analyzed using the Statistical Package for Social Sciences (SPSS) software.

Results

The calculated Case Fatality Ratio was 0.7%. The incidence of COVID-19 among UNRWA staff in Jordan during the period of our study was 20.1%. A total of 366 respondents, 220 (60.1%) females and 146 (39.9%) males were included in the study. The mean (SD) age was 44.2 (8.0) years. Most of the infected (97.8%) developed acute COVID-19 symptoms. Fatigue, fever, joint pain, loss of smell and taste, and cough were the most common symptoms. According to WHO clinical classification of acute illness severity, 65.0% had mild illness. Only 28.7% of all subjects fully recovered from the infection, while most of them (71.3%) continued to suffer from many symptoms. Persistent fatigue (39.7%), shortness of breath (SOB) with activity (18.8%), anxiety (17.4%), forgetfulness (16.9%), trouble in concentrating (16.7%), and depressed mood (15.8%) were the most frequently reported.

Conclusion

Post COVID-19 illness was very common (71.3%) calling for UNRWA to continue assessment of post COVID-19 syndrome and the medical and psychological needs of affected staff. Despite vaccination, only 2.2% of the infected were asymptomatic. Reinfection was unusually high (24%).
"Knowledge regarding cardiopulmonary resuscitation among health assistants in Nepal: A cross-sectional study"
Authors: Singh Bivek , Shankar Pathiyil Ravi
Published: November 2023

Background

Health assistants play a crucial role in healthcare delivery, particularly in remote and rural areas of Nepal. They should have adequate lifesaving and resuscitation skills. Therefore, assessing their cardiopulmonary resuscitation (CPR) knowledge is essential.

Objective

To evaluate the knowledge of CPR among health assistants (HAs) in Nepal and explore if there were variations in knowledge scores based on the demographic characteristics of the participants.

Methods

A quantitative cross-sectional research design was used. The study population included HAs registered with the Nepal Health Professional Council (NHPC) who completed three years of training. Non-probability convenience sampling was employed. Data was collected using an online survey based on the 2020 American Heart Association guidelines. Demographic information and participants’ knowledge levels were noted.

Results

The study involved 500 HAs, with the majority being male and working in government hospitals. Most participants were from Madhesh Province, and the median age was 26 years. Only a fraction of the participants had received training in CPR, and none of them had ever performed CPR. The median knowledge scores were higher among males and among respondents from Madhesh, Lumbini, Karnali, and Sudhurpaschim provinces. The HA’s knowledge of the correct depth of CPR compression for children (21%) and infants (17.4%) was limited. CPR scores were different according to variables like training, theory understanding, and practice duration, among others. The findings highlighted the need for more practical training and regular refresher courses to enhance HAs ability to provide life-saving interventions.

Conclusion

The study revealed less CPR knowledge and a lack of practical training among HAs in Nepal. To improve healthcare outcomes, providing practical training and ongoing education on CPR is crucial. The findings can contribute to curriculum development and policy changes in healthcare delivery.
Narcissus’ belief about his body: Aspects of narcissism, body image, and eating disorder symptoms
Authors: Szymczak Piotr , Talbot Daniel , Gritti Emanuela S. , Jonason Peter K.
Published: November 2023

Objective

Narcissism may play a role in shaping body image concerns. Here we examined the relationships between narcissism (i.e., agentic extraversion, antagonism, narcissistic neuroticism, leadership/authority, exhibitionism/entitlement) and body image concerns and disturbances (i.e., drive for thinness, drive for muscularity, eating disorder symptoms, body mass index, current/desired fat, and current/desired muscularity).

Methods

Mechanical Turk workers from the USA (N = 430; 64% male) completed the Narcissistic Admiration and Rivalry Questionnaire, the Hypersensitive Narcissism Scale, the Narcissistic Personality Inventory, the Drive for Muscularity Scale, the Drive for Thinness Scale, the Eating Disorder Examination Questionnaire–Short, and the Sex-Specific Somatomorphic Matrixes.

Results

All narcissistic factors were associated with a greater drive for thinness (except for leadership/authority) and for muscularity, more eating disorder symptoms, a greater desired body fat (except for leadership/authority), and a greater current muscularity. Greater agentic extraversion and exhibitionism/entitlement were associated with lower levels of current body fat, and greater antagonism was associated with a greater desired muscularity.

Discussion

Notably, individual differences in narcissism appeared to be important in understanding body image concerns, broadly speaking. We found that narcissism may be associated with body image concerns among both sexes differently, and especially that drive for thinness was more related to narcissism in men. Our results emphasize the importance of narcissism in formulating and treating body image-related disorders for both men and women. Ultimately, narcissistic features of personality may be risk factors for developing and perpetuating body image concerns, and therefore should be considered in assessment, formulation, diagnosis, and treatment of eating disorders.
Study on rheological properties of POE/VO compound recycled asphalt
Authors: Mei Hua , Hu Zhaoxia , Zheng Zhenyuan , Zeng Junyi , Yu Lei
Published: November 2023

In order to improve the high temperature performance of Vegetable oil recycled asphalt, this study used Polyolefin elastomer (POE) and vegetable oil (VO) to compound recycled aging asphalt. The properties of recycled asphalt were compared and analyzed by conventional physical properties and high & low temperature rheological tests. The results show that 8% VO content can achieve the best regeneration effect. Based on this VO dosage, a variety of POE/VO combination mixture schemes were designed and tested to obtain excellent deformation resistance of recycled aging asphalt under high temperature environments. The POE/VO combination with an appropriate dosage can restore the high temperature deformation resistance and elastic recovery performance even beyond the pre-aging level, and increase the critical temperature by 4~10°C. Considering the physical properties and rheological properties of asphalt, the recommended ratio of POE/VO composite recycled asphalt is 8% VO+4% POE and 8% VO+6% POE.
Definition and terminology of developmental language disorders—Interdisciplinary consensus across German-speaking countries
Authors: Lüke Carina , Kauschke Christina , Dohmen Andrea , Haid Andrea , Leitinger Christina , Männel Claudia , Penz Tanja , Sachse Steffi , Scharff Rethfeldt Wiebke , Spranger Julia , Vogt Susanne , Niederberger Marlen , Neumann Katrin
Published: November 2023

In recent years, there have been intense international discussions about the definition and terminology of language disorders in childhood, such as those sparked by the publications of the CATALISE consortium. To address this ongoing debate, a Delphi study was conducted in German-speaking countries. This study consisted of three survey waves and involved over 400 experts from relevant disciplines. As a result, a far-reaching consensus was achieved on essential definition criteria and terminology, presented in 23 statements. The German term ‘Sprachentwicklungsstörung’ was endorsed to refer to children with significant deviations from typical language development that can negatively impact social interactions, educational progress, and/or social participation and do not occur together with a potentially contributing impairment. A significant deviation from typical language development was defined as a child’s scores in standardized test procedures being ≥ 1.5 SD below the mean for children of the same age. The results of this Delphi study provide a proposal for a uniform use of terminology for language disorders in childhood in German-speaking countries.
The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination
Authors: Kråkenes Torbjørn , Wergeland Stig , Al-Sharabi Niyaz , Mohamed-Ahmed Samih , Fromreide Siren , Costea Daniela-Elana , Mustafa Kamal , Bø Lars , Kvistad Christopher Elnan
Published: November 2023

Introduction

Multiple sclerosis (MS) is characterized by chronic inflammation, demyelination, and axonal degeneration within the central nervous system (CNS), for which there is no current treatment available with the ability to promote neuroprotection or remyelination. Some aspects of the progressive form of MS are displayed in the murine cuprizone model, where demyelination is induced by the innate immune system without major involvement of the adaptive immune system. Mesenchymal stem cells (MSCs) are multipotent cells with immunomodulatory and neuroprotective potential. In this study, we aimed to assess the neuroprotective potential of MSCs from bone marrow (BM-MSCs) and stem cells from human exfoliated deciduous teeth (SHED) in the cuprizone model.

Methods

Human BM-MSCs and SHED were isolated and characterized. Nine-week-old female C57BL/6 mice were randomized to receive either human BM-MSCs, human SHED or saline intraperitoneally. Treatments were administered on day -1, 14 and 21. Outcomes included levels of local demyelination and inflammation, and were assessed with immunohistochemistry and histology.

Results

BM-MSCs were associated with increased myelin content and reduced microglial activation whereas mice treated with SHED showed reduced microglial and astroglial activation. There were no differences between treatment groups in numbers of mature oligodendrocytes or axonal injury. MSCs were identified in the demyelinated corpus callosum in 40% of the cuprizone mice in both the BM-MSC and SHED group.

Conclusion

Our results suggest a neuroprotective effect of MSCs in a toxic MS model, with demyelination mediated by the innate immune system.
Examination of 2D frontal and sagittal markerless motion capture: Implications for markerless applications
Authors: Wade Logan , Needham Laurie , Evans Murray , McGuigan Polly , Colyer Steffi , Cosker Darren , Bilzon James
Published: November 2023

This study examined if occluded joint locations, obtained from 2D markerless motion capture (single camera view), produced 2D joint angles with reduced agreement compared to visible joints, and if 2D frontal plane joint angles were usable for practical applications. Fifteen healthy participants performed over-ground walking whilst recorded by fifteen marker-based cameras and two machine vision cameras (frontal and sagittal plane). Repeated measures Bland-Altman analysis illustrated that markerless standard deviation of bias and limits of agreement for the occluded-side hip and knee joint angles in the sagittal plane were double that of the camera-side (visible) hip and knee. Camera-side sagittal plane knee and hip angles were near or within marker-based error values previously observed. While frontal plane limits of agreement accounted for 35–46% of total range of motion at the hip and knee, Bland-Altman bias and limits of agreement (-4.6–1.6 ± 3.7–4.2˚) were actually similar to previously reported marker-based error values. This was not true for the ankle, where the limits of agreement (± 12˚) were still too high for practical applications. Our results add to previous literature, highlighting shortcomings of current pose estimation algorithms and labelled datasets. As such, this paper finishes by reviewing methods for creating anatomically accurate markerless training data using marker-based motion capture data.
Improved meta-analysis pipeline ameliorates distinctive gene regulators of diabetic vasculopathy in human endothelial cell (hECs) RNA-Seq data
Authors: Pandey Diksha , Perumal P. Onkara
Published: November 2023

Enormous gene expression data generated through next-generation sequencing (NGS) technologies are accessible to the scientific community via public repositories. The data harboured in these repositories are foundational for data integrative studies enabling large-scale data analysis whose potential is yet to be fully realized. Prudent integration of individual gene expression data i.e. RNA-Seq datasets is remarkably challenging as it encompasses an assortment and series of data analysis steps that requires to be accomplished before arriving at meaningful insights on biological interrogations. These insights are at all times latent within the data and are not usually revealed from the modest individual data analysis owing to the limited number of biological samples in individual studies. Nevertheless, a sensibly designed meta-analysis of select individual studies would not only maximize the sample size of the analysis but also significantly improves the statistical power of analysis thereby revealing the latent insights. In the present study, a custom-built meta-analysis pipeline is presented for the integration of multiple datasets from different origins. As a case study, we have tested with the integration of two relevant datasets pertaining to diabetic vasculopathy retrieved from the open source domain. We report the meta-analysis ameliorated distinctive and latent gene regulators of diabetic vasculopathy and uncovered a total of 975 i.e. 930 up-regulated and 45 down-regulated gene signatures. Further investigation revealed a subset of 14 DEGs including CTLA4, CALR, G0S2, CALCR, OMA1, and DNAJC3 as latent i.e. novel as these signatures have not been reported earlier. Moreover, downstream investigations including enrichment analysis, and protein-protein interaction (PPI) network analysis of DEGs revealed durable disease association signifying their potential as novel transcriptomic biomarkers of diabetic vasculopathy. While the meta-analysis of individual whole transcriptomic datasets for diabetic vasculopathy is exclusive to our comprehension, however, the novel meta-analysis pipeline could very well be extended to study the mechanistic links of DEGs in other disease conditions.
Ecological niche modelling of two water-dependant birds informs the conservation needs of riverine ecosystems outside protected area network in the Eastern Himalaya, India
Authors: Tamang Roshan , Jins Vallanattu James , Dewan Sailendra , Chaudhry Shivaji , Rawat Seema , Acharya Bhoj Kumar
Published: November 2023

Common species often play vital roles in ecosystem functions and processes. Globally, conservation strategies are mostly focused on threatened species and rarely explored the potential of using common species as indicators of critical ecosystems. The Himalayan mountains have unique riverine ecosystems harbouring high diversity of specialist river birds. Ecological niche modelling provides effective tools to predict suitable habitats of a species and identify habitats for conservation. We used two common water-dependent bird species, Blue Whistling Thrush and White-capped Water Redstart as indicators of riverine ecosystems within the Sikkim Himalayan region and predicted their suitable habitats using an ensemble modelling approach. We selected six predictor variables for the final model including three bioclimatic and three topographic variables. For both species, bioclimatic variables such as mean annual temperature and precipitation were the most important factors compared to topographic variables. At least 70 percent of the most suitable habitats are distributed below 2000 m elevation alongside major drainages. Also, most of their potential habitats are distributed outside the protected area networks in the region. This habitat suitability pattern may be applied to other sympatric species in the region. Since major water bodies in Sikkim are largely affected by developmental activities and climate change, these riverine birds might face threats of losing suitable habitats. We recommend a dynamic approach to evaluate the habitat quality of riverine birds, especially outside protected area networks in the region to plan conservation strategies. This approach will ensure habitat conservation of many water-dependent birds and other taxa associated with the riverine ecosystems of the Eastern Himalaya.
Assessment of the human response to acute mental stress–An overview and a multimodal study
Authors: Ernst Hannes , Scherpf Matthieu , Pannasch Sebastian , Helmert Jens R. , Malberg Hagen , Schmidt Martin
Published: November 2023

Numerous vital signs are reported in association with stress response assessment, but their application varies widely. This work provides an overview over methods for stress induction and strain assessment, and presents a multimodal experimental study to identify the most important vital signs for effective assessment of the response to acute mental stress. We induced acute mental stress in 65 healthy participants with the Mannheim Multicomponent Stress Test and acquired self-assessment measures (Likert scale, Self-Assessment Manikin), salivary α-amylase and cortisol concentrations as well as 60 vital signs from biosignals, such as heart rate variability parameters, QT variability parameters, skin conductance level, and breath rate. By means of statistical testing and a self-optimizing logistic regression, we identified the most important biosignal vital signs. Fifteen biosignal vital signs related to ventricular repolarization variability, blood pressure, skin conductance, and respiration showed significant results. The logistic regression converged with QT variability index, left ventricular work index, earlobe pulse arrival time, skin conductance level, rise time and number of skin conductance responses, breath rate, and breath rate variability (F1 = 0.82). Self-assessment measures indicated successful stress induction. α-amylase and cortisol showed effect sizes of -0.78 and 0.55, respectively. In summary, the hypothalamic-pituitary-adrenocortical axis and sympathetic nervous system were successfully activated. Our findings facilitate a coherent and integrative understanding of the assessment of the stress response and help to align applications and future research concerning acute mental stress.
Participant perceptions and experiences of a novel community-based respiratory longitudinal sampling method in Liverpool, UK: A mixed methods feasibility study
Authors: German Esther L. , Nabwera Helen M. , Robinson Ryan , Shiham Farah , Liatsikos Kostas , Parry Christopher M. , McNamara Claire , Kattera Sanjana , Carter Katie , Howard Ashleigh , Pojar Sherin , Hamilton Joshua , Matope Agnes , Read Jonathan M. , Allen Stephen J. , Hill Helen , Hawcutt Daniel B. , Urban Britta C. , Collins Andrea M. , Ferreira Daniela M. , Nikolaou Elissavet
Published: November 2023

Longitudinal, community-based sampling is important for understanding prevalence and transmission of respiratory pathogens. Using a minimally invasive sampling method, the FAMILY Micro study monitored the oral, nasal and hand microbiota of families for 6 months. Here, we explore participant experiences and opinions. A mixed methods approach was utilised. A quantitative questionnaire was completed after every sampling timepoint to report levels of discomfort and pain, as well as time taken to collect samples. Participants were also invited to discuss their experiences in a qualitative structured exit interview. We received questionnaires from 36 families. Most adults and children >5y experienced no pain (94% and 70%) and little discomfort (73% and 47% no discomfort) regardless of sample type, whereas children ≤5y experienced variable levels of pain and discomfort (48% no pain but 14% hurts even more, whole lot or worst; 38% no discomfort but 33% moderate, severe, or extreme discomfort). The time taken for saliva and hand sampling decreased over the study. We conducted interviews with 24 families. Families found the sampling method straightforward, and adults and children >5y preferred nasal sampling using a synthetic absorptive matrix over nasopharyngeal swabs. It remained challenging for families to fit sampling into their busy schedules. Adequate fridge/freezer space and regular sample pick-ups were found to be important factors for feasibility. Messaging apps proved extremely effective for engaging with participants. Our findings provide key information to inform the design of future studies, specifically that self-sampling at home using minimally invasive procedures is feasible in a family context.