bluuebunny/crossref_metadata_2025 huggingface dataset:
Seeking ‘A Fair Field’ for Women in the Legal Profession: Pioneering Women Lawyers from Burma of 1924-1935
Authors: Chen Li , Li Yi
Published: September 2020

The enactment of the Sex Disqualification (Removal) Act in 1919 tore down a significant gender barrier and opened doors of the once exclusively male legal profession in the United Kingdom. This article focuses on its early beneficiaries in Burma, a less studied colony of the Empire in the late 1920s and early 1930s. It traces the first four women barristers from colonial Burma, and their odyssey to gain tradecraft and skills through seeking legal education at the Inns of Court in London. It evaluates their performances at the Bar Examination and explores the challenges they faced as they beat a path into the traditionally male-dominated legal profession. Finally, the paper shows how these pioneering women barristers were able to utilise the fruits of their legal education to further the cause of promoting gender equality upon their return to Burma. However, their professional success also reveals the persistence of gender and racial hierarchies across the Empire despite ongoing legal reformation and political activism, as they were subjected to confrontations and discriminations throughout their career.
Intrastate Conflict and Natural Resources: A Question of Geology?
Authors: Boyes Christina
Published: September 2020

How do natural resources deposits affect how armed actors behave in intrastate conflict? I argue that armed actors use a strategic calculus which includes resource extraction complexity when determining which natural resource deposits to fight over. Although often unaddressed, the extraction process directly affects the ‘lootability’ of a resource as well as the relationship of local, state, and international governments and multinational corporations with the actors that control natural resource deposits. I argue that sedimentary deposits, which pose minor technical complexity and human capital, but are more difficult to exploit than surficial deposits and easier to exploit than igneous or metamorphic deposits, are the most likely sites of violence in intrastate conflict. Using this novel conceptualization of natural resources by geological characteristics, I find support for this hypothesis at the global level.
Goat’s Blood, Tablets and Sacred Ivy
Authors: Ali Nabil
Published: September 2020

The ivy plant has clung onto the imagination of creative expression since classical poets wrote plays about ancient rituals and how they altered the mindset of daily communities. Several medieval technical manuscripts describe processes for transforming copper tablets into a golden colour using ivy berry juice and the blood of a goat. These recipes – possibly originating from ancient practices and forgotten cultures – detail working methods using alchemic processes formulated through the art of transmuting metals. The symbolic significance of ivy and the goat outlined in these recipes can be associated with ‘Dionysus’ – the deity of intoxicated ecstasy and natural forces – manifested by the hypnotic trance of ritual dances reenacted by female maenads and pre-dynastic cult practices. Remnants of the recipes are practical factors which may have previously been part of a ritual tradition, rooted inside the craftsman's trade dating back to antiquity.
Hubungan Riwayat Imunisasi dengan Status Gizi Balita
Authors: Jamil Siti Nurhasiyah , Subiyatin Aning
Published: September 2020

The toddler period is a period that must be observed property, at this time the direction of child development will be determined for the next period. The purpose of this study was to study the immunization status of nutritional status in infants. The research design used was cross-sectional in the work area of Johar Baru Health Center, Jakarta Pusat, which was conducted from April–June 2019. The population of all children aged 6-59 months, while the study sample was infants with stunting of 105 respondents, which is data child nutrition in Health Center. Data processing and analysis using SPSS with Chi-Square statistical test, the confidence level of 95%. The results of variables related to the nutritional status of children under five are the relationship of immunization P value (0.004 OR and CI (0.173 (0.051-0.59). The conclusion of the variable related to the nutritional status of under-five children is immunization.
Teknik Mekanika Tubuh Mengurangi Tingkat Nyeri Punggung Bawah pada Ibu Hamil Trimester III
Authors: Rahayu Nur Azizah Putri , Rafika Rafika , Suryani Lili , Hadriani Hadriani
Published: September 2020

In order to reduce and prevent back pain complaints and to form safe and comfortable daily activities during pregnancy, pregnant women need proper body mechanics. The purpose of this research is to know the influence of the application of mechanical body mechanics with lower back pain of the III trimester of pregnant women. This type of research is pre-experimental with one group Pretest posttest design. This research was conducted in the working area of Puskesmas Sangurara.  The population in this study is all III-trimester pregnant mothers with a sample number of 31 people, taken with a consecutive sampling technique. The treatment given is the technique of body mechanics observed during 1 week. Data collection using an observation sheet. The results showed before performing mechanical body mechanics there were 71% of respondents experienced moderate pain and after conducting mechanical body mechanics there were 74.2% of respondents experienced mild pain. Based on the Wilcoxon test obtained a p-value <0.001, with an average decrease in pain, is 7.50. The conclusion is the application of body mechanics techniques significantly affect the lower back pain of the III trimester of pregnant women.
Strategic Decisions between Short-Term Profit and Sustainability
Authors: Haessler Philipp
Published: September 2020

Sustainability has evolved into one of the key topics for organizations and organizational researchers alike. To meet changing societal demands, organizations have to adapt their long-term strategies and incorporate environmental and social aspects into their product offerings and decision-making. However, at the same time companies must satisfy short-term profitability interests and demands from shareholders. An organization’s sustainability commitment, strategy, or view is impacted by several influential factors, e.g., by the top management commitment or stakeholder integration. These factors have largely been studied individually without linking them. As such, the following study aims at creating a holistic view and framework for organizational influences and on sustainability. The framework is validated by a comparison to industrial practice in interviews with sustainability managers from the chemical and automobile industry, which are both highly relevant in the context of sustainability. Interview results suggest that the identified influential factors attributed to the four framework layers organization, top management, project team and project are relevant for industrial representatives. The view on and impact of specific influential factors can vary between companies and industries. The study further gives insights into the actual status and future direction of the management of corporate sustainability (CS) in practice.
Improvement of the Water Quality in Rainbow Trout Farming by Means of the Feeding Type and Management over 10 Years (2009–2019)
Authors: Fiordelmondo Elisa , Magi Gian Enrico , Mariotti Francesca , Bakiu Rigers , Roncarati Alessandra
Published: September 2020

Background: In Europe, rainbow trout is one of the main fresh water fish farmed in a constantly developing environment that requires innovative studies to improve farm management, fish welfare and environmental sustainability. The aim of this paper is to investigate the trend of water quality parameters over 10 years, after a feeding strategy change from pellet to extruded feed. Methods: The study was conducted on a farm in central Italy, based on parallel raceways. The cycle started from young rainbow trout (90 ± 2 g) that were grown until they reached market size. A water sample of 500 cm3 was collected monthly from 2009 to 2019 from the lagoon basin in order to investigate the trends of the total suspended solids (TSS), biochemical oxygen demand (BOD5), chemical oxygen demand (COD), nitrites (NO2-N), nitrates (NO3-N), total ammonia nitrogen (TAN), total phosphorus (TP) and pH. Results: All of the studied parameters (TSS, BOD5, COD, NO2-N, NO3-N, TAN and TP) showed a significant improvement from 2009 to 2019. The pH parameter did not display notable variation during the studied period. The feed conversion ratio (FCR) was also investigated and exhibited a significant improvement from 1.4 to 1.1. Conclusion: Based on the decrease of all the investigated parameters, it is possible to say that extrusion is currently an excellent processing feed technique in aquaculture with a good level of respect for the environment.
A Genetic Window on Sardinian Native Horse Breeds through Uniparental Molecular Systems
Authors: Giontella Andrea , Cardinali Irene , Pieramati Camillo , Cherchi Raffaele , Biggio Giovanni Paolo , Achilli Alessandro , Silvestrelli Maurizio , Lancioni Hovirag
Published: September 2020

Sardinia, an island located to the west of Italy in the Mediterranean Sea, boasts three native horse breeds: Giara, Sarcidano, and Sardinian Anglo-Arab. Here, we have investigated for the first time three loci of the non-recombining region of the Y chromosome (NRY) in 34 stallions from these breeds and performed a phylogenetic analysis of the maternal relationships among 178 previously published mitochondrial control regions. We found that the current NRY diversity of Sardinian horse breeds is linked to three haplotypes (HT), all identified within Sarcidano. Each breed showed a typical HT: HT1 (ancestral) was the most represented in Sarcidano, HT2 (Neapolitan/Oriental wave) in Giara, and HT3 (Thoroughbred wave) in Sardinian Anglo-Arab. The specificity of each haplotype suggests the influence of independent breeding strategies and the effect of genetic drift in each Sardinian population. The female counterpart, extended to 178 horses, showed a low genetic variability and a common maternal origin for Giara and Sarcidano. The higher variability of the Sardinian Anglo-Arab indicates multiple mare lineages in its current population. Further genetic analyses will be crucial to understand the paternal history of male horses, preserve the endangered mares’ and stallions’ lineages, and improve the enhancement of autochthonous genetic resources on this island.
Nanofabrication Techniques in Large-Area Molecular Electronic Devices
Authors: Herrer Lucía , Martín Santiago , Cea Pilar
Published: September 2020

The societal impact of the electronics industry is enormous—not to mention how this industry impinges on the global economy. The foreseen limits of the current technology—technical, economic, and sustainability issues—open the door to the search for successor technologies. In this context, molecular electronics has emerged as a promising candidate that, at least in the short-term, will not likely replace our silicon-based electronics, but improve its performance through a nascent hybrid technology. Such technology will take advantage of both the small dimensions of the molecules and new functionalities resulting from the quantum effects that govern the properties at the molecular scale. An optimization of interface engineering and integration of molecules to form densely integrated individually addressable arrays of molecules are two crucial aspects in the molecular electronics field. These challenges should be met to establish the bridge between organic functional materials and hard electronics required for the incorporation of such hybrid technology in the market. In this review, the most advanced methods for fabricating large-area molecular electronic devices are presented, highlighting their advantages and limitations. Special emphasis is focused on bottom-up methodologies for the fabrication of well-ordered and tightly-packed monolayers onto the bottom electrode, followed by a description of the top-contact deposition methods so far used.
Lactoferrin-Derived Peptides as a Control Strategy against Skinborne Staphylococcal Biofilms
Authors: Quintieri Laura , Caputo Leonardo , Monaci Linda , Cavalluzzi Maria Maddalena , Denora Nunzio
Published: September 2020

Coagulase-negative staphylococci (CoNS) widely colonize the human skin and play an active role in host defense. However, these bacteria may cause malodours and increase infection incidence rate in immune-compromised patients and individuals with catheters and implants. CoNS spreading is favored by biofilm formation that also promotes the release of virulence factors and drug resistance. Biofilm control or eradication by antimicrobial peptides (AMPs) represents an attractive strategy which is worth investigating. In this work, bovine lactoferrin (BLF) hydrolysate (HLF) was in vitro evaluated for its antimicrobial and antibiofilm activities against skin-related coagulase negative and positive staphylococci. Despite a minimal inhibitory concentration (MIC) recorded for HLF ranging from 10 to more than 20 mg/mL, a minimal biofilm inhibitory concentration (MIBC) equal to 2.5 mg/mL was found for most target strains. Conversely, MIBC values referred to the individual peptides, LFcinB or LFmpin (herein purified and identified) were significantly lower. Finally, the application of 2.5 mg/mL HLF solution by dipping and spraying on biofilm-attached glass surfaces also caused a high biofilm eradication rate depending on the incubation time, thus attracting interest for future applications in cosmetic formulation for skin care.
Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Renal Cell Carcinoma
Authors: Zhang Ying , Ellinger Jörg , Ritter Manuel , Schmidt-Wolf Ingo G. H.
Published: September 2020

There is growing interest in cytokine-induced killer (CIK) cells on the integrated therapy of patients with RCC, especially those in the late stage or refractory to conventional chemotherapy and radiotherapy. In this review, a total of 15 clinical studies including 681 patients enrolled in CIK cell immunotherapy were outlined. Three-hundred-and-eighty-two patients with RCC were treated with CIK cells alone or in combination with DC vaccination, targeted agents sunitinib or sorafenib, and the PD-1 inhibitor pembrolizumab. Significantly improved 3-year overall survival rate was reported in four trials, whereas remarkably longer median progression-free survival was observed in three studies. Adverse reactions were mild and usually controllable fever and fatigue. Besides, preclinical research progresses were reviewed to increase our understanding about the underlying mechanisms of CIK cell cytotoxicity and identify potential targets to enhance their anti-tumor activity. These studies suggest that CIK cell-based immunotherapy has potential clinical benefits with a good safety profile and could become a promising approach in the combined therapies of RCC patients. However, further large-scale studies are required to evaluate the clinical efficacy of CIK cells and more efforts should be performed to identify the optimal CIK cell-based therapeutic regimen for RCC patients.
Critical Role for Cold Shock Protein YB-1 in Cytokinesis
Authors: Mehta Sunali , Algie Michael , Al-Jabry Tariq , McKinney Cushla , Kannan Srinivasaraghavan , Verma Chandra S , Ma Weini , Zhang Jessie , Bartolec Tara K. , Masamsetti V. Pragathi , Parker Kim , Henderson Luke , Gould Maree L , Bhatia Puja , Harfoot Rhodri , Chircop Megan , Kleffmann Torsten , Cohen Scott B , Woolley Adele G , Cesare Anthony J , Braithwaite Antony
Published: September 2020

High levels of the cold shock protein Y-box-binding protein-1, YB-1, are tightly correlated with increased cell proliferation and progression. However, the precise mechanism by which YB-1 regulates proliferation is unknown. Here, we found that YB-1 depletion in several cancer cell lines and in immortalized fibroblasts resulted in cytokinesis failure and consequent multinucleation. Rescue experiments indicated that YB-1 was required for completion of cytokinesis. Using confocal imaging we found that YB-1 was essential for orchestrating the spatio-temporal distribution of the microtubules, β-actin and the chromosome passenger complex (CPC) to define the cleavage plane. We show that phosphorylation at six serine residues was essential for cytokinesis, of which novel sites were identified using mass spectrometry. Using atomistic modelling we show how phosphorylation at multiple sites alters YB-1 conformation, allowing it to interact with protein partners. Our results establish phosphorylated YB-1 as a critical regulator of cytokinesis, defining precisely how YB-1 regulates cell division.
Entosis: From Cell Biology to Clinical Cancer Pathology
Authors: Mlynarczuk-Bialy Izabela , Dziuba Ireneusz , Sarnecka Agnieszka , Platos Emilia , Kowalczyk Magdalena , Pels Katarzyna K. , Wilczynski Grzegorz M. , Wojcik Cezary , Bialy Lukasz P.
Published: September 2020

Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis.
Lenalidomide in Combination with Arsenic Trioxide: an Effective Therapy for Primary Effusion Lymphoma
Authors: Moodad Sara , El Hajj Rana , Hleihel Rita , Hajjar Layal , Tawil Nadim , Karam Martin , Hamie Maguy , Abou Merhi Raghida , El Sabban Marwan , El Hajj Hiba
Published: September 2020

Primary effusion lymphoma (PEL) is a rare aggressive subset of non-Hodgkin B cell lymphoma. PEL is secondary to Kaposi sarcoma herpes virus (KSHV) and predominantly develops in serous cavities. Conventional chemotherapy remains the treatment of choice for PEL and yields high response rates with no significant comorbidities. Yet, chemotherapy often fails in achieving or maintaining long-term remission. Lenalidomide (Lena), an immunomodulatory drug, displayed some efficacy in the treatment of PEL. On the other hand, arsenic trioxide (ATO) in combination with other agents effectively treated a number of blood malignancies, including PEL. In this study, we present evidence that the combination of ATO/Lena significantly enhanced survival of PEL mice, decreased the volume of exacerbated ascites in the peritoneum, and reduced tumor infiltration in organs of treated animals. In ex vivo treated PEL cells, ATO/Lena decreased the proliferation and downregulated the expression of KSHV latent viral proteins. This was associated with decreased NF-κB activation, resulting in reactivation of viral replication, downregulation of interleukin-6 (IL-6) and IL-10, inhibition of vascular endothelial growth factor, and apoptosis. Our results elucidate the mechanism of action of ATO/Lena and present it as a promising targeted therapeutic modality in PEL management, which warrants further clinical investigation.
Recent Advances in Asymmetric Catalytic Electrosynthesis
Authors: Margarita Cristiana , Lundberg Helena
Published: September 2020

The renewed interest in electrosynthesis demonstrated by organic chemists in the last years has allowed for rapid development of new methodologies. In this review, advances in enantioselective electrosynthesis that rely on catalytic amounts of organic or metal-based chiral mediators are highlighted with focus on the most recent developments up to July 2020. Examples of C-H functionalization, alkene functionalization, carboxylation and cross-electrophile couplings are discussed, along with their related mechanistic aspects.
Two-Stage Catalytic Abatement of N2O Emission in Nitric Acid Plants
Authors: Inger Marek , Moszowski Bartosz , Ruszak Monika , Rajewski Jakub , Wilk Marcin
Published: September 2020

Different variants for abatement of N2O emission from nitric acid plants with the use of catalysts developed at Łukasiewicz-INS were analyzed. Activity tests on a pilot scale confirmed the high activity of the studied catalysts. A two-stage catalytic abatement of N2O emission in nitric acid plants was proposed: by high-temperature decomposition in the nitrous gases stream (HT-deN2O) and low-temperature decomposition in the tail gas stream (LT-deN2O). The selection of the optimal variant for abatement of N2O emission depends on the individual characteristics of the nitric acid plant: ammonia oxidation parameters, construction of ammonia oxidation reactor and temperature of the tail gas upstream of the expansion turbine. It was shown that the combination of both deN2O technologies, taking into account their technological constraints (dimensions of the catalyst bed), allows for a greater abatement of N2O emission, than the use of only one technology. This solution may be economically advantageous regarding the high prices of CO2 emission allowances.
Kinetic Study of the Herrmann–Beller Palladacycle-Catalyzed Suzuki–Miyaura Coupling of 4-Iodoacetophenone and Phenylboronic Acid
Authors: Bourouina Amine , Oswald Alexis , Lido Valentin , Dong Lu , Rataboul Franck , Djakovitch Laurent , de Bellefon Claude , Meille Valérie
Published: September 2020

This article presents an experimental kinetic study of the Suzuki–Miyaura reaction of 4-iodoacetophenone with phenylboronic acid catalyzed by the Herrmann–Beller palladacycle. This catalyst, together with the solvent (ethanol) and the base (sodium methylate), were chosen to ensure catalyst stability and reactants solubility all along the reaction. Based on the study of initial reaction rates, a quasi-first-order was found for 4-iodoacetophenone with a first-order dependence on the initial concentration of palladium. A zero-order was found for the base and the phenylboronic acid. The oxidative addition step of the mechanism was thus considered as the rate determining step. A global rate law was derived and validated quantitatively. A global activation energy, with an average value of ca. 63 kJ/mol was determined.
Ru and Ni—Privileged Metal Combination for Environmental Nanocatalysis
Authors: Polanski Jaroslaw , Lach Daniel , Kapkowski Maciej , Bartczak Piotr , Siudyga Tomasz , Smolinski Adam
Published: September 2020

Privileged structures is a term that is used in drug design to indicate a fragment that is popular in the population of drugs or drug candidates that are in the application or investigation phases, respectively. Privileged structures are popular motifs because they generate efficient drugs. Similarly, some elements appear to be more efficient and more popular in catalyst design and development. To indicate this fact, we use here a term privileged metal combination. In particular, Ru-based catalysts have paved a bumpy road in a variety of commercial applications from ammonia synthesis to carbon (di)oxide methanation. Here, we review Ru/Ni combinations in order to specifically find applications in environmental nanocatalysis and more specifically in carbon (di)oxide methanation. Synergy, ensemble and the ligand effect are theoretical foundations that are used to explain the advantages of multicomponent catalysis. The economic effect is another important issue in blending metal combinations. Low temperature and photocatalytic processes can be indicated as new tendencies in carbon (di)oxide methanation. However, due to economics, future industrial developments of this reaction are still questionable.
Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond
Authors: Wesch Nicole , Kirkin Vladimir , Rogov Vladimir V.
Published: September 2020

Autophagy is a common name for a number of catabolic processes, which keep the cellular homeostasis by removing damaged and dysfunctional intracellular components. Impairment or misbalance of autophagy can lead to various diseases, such as neurodegeneration, infection diseases, and cancer. A central axis of autophagy is formed along the interactions of autophagy modifiers (Atg8-family proteins) with a variety of their cellular counter partners. Besides autophagy, Atg8-proteins participate in many other pathways, among which membrane trafficking and neuronal signaling are the most known. Despite the fact that autophagy modifiers are well-studied, as the small globular proteins show similarity to ubiquitin on a structural level, the mechanism of their interactions are still not completely understood. A thorough analysis and classification of all known mechanisms of Atg8-protein interactions could shed light on their functioning and connect the pathways involving Atg8-proteins. In this review, we present our views of the key features of the Atg8-proteins and describe the basic principles of their recognition and binding by interaction partners. We discuss affinity and selectivity of their interactions as well as provide perspectives for discovery of new Atg8-interacting proteins and therapeutic approaches to tackle major human diseases.
The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription
Authors: Langer Simon , Yin Xin , Diaz Arturo , Portillo Alex J. , Gordon David E. , Rogers Umu H. , Marlett John M. , Krogan Nevan J. , Young John A. T. , Pache Lars , Chanda Sumit K.
Published: September 2020

The infectious life cycle of the human immunodeficiency virus type 1 (HIV-1) is characterized by an ongoing battle between a compendium of cellular proteins that either promote or oppose viral replication. On the one hand, HIV-1 utilizes dependency factors to support and sustain infection and complete the viral life cycle. On the other hand, both inducible and constitutively expressed host factors mediate efficient and functionally diverse antiviral processes that counteract an infection. To shed light into the complex interplay between HIV-1 and cellular proteins, we previously performed a targeted siRNA screen to identify and characterize novel regulators of viral replication and identified Cullin 3 (Cul3) as a previously undescribed factor that negatively regulates HIV-1 replication. Cul3 is a component of E3-ubiquitin ligase complexes that target substrates for ubiquitin-dependent proteasomal degradation. In the present study, we show that Cul3 is expressed in HIV-1 target cells, such as CD4+ T cells, monocytes, and macrophages and depletion of Cul3 using siRNA or CRISPR/Cas9 increases HIV-1 infection in immortalized cells and primary CD4+ T cells. Conversely, overexpression of Cul3 reduces HIV-1 infection in single replication cycle assays. Importantly, the antiviral effect of Cul3 was mapped to the transcriptional stage of the viral life cycle, an effect which is independent of its role in regulating the G1/S cell cycle transition. Using isogenic viruses that only differ in their promotor region, we find that the NF-κB/NFAT transcription factor binding sites in the LTR are essential for Cul3-dependent regulation of viral gene expression. Although Cul3 effectively suppresses viral gene expression, HIV-1 does not appear to antagonize the antiviral function of Cul3 by targeting it for degradation. Taken together, these results indicate that Cul3 is a negative regulator of HIV-1 transcription which governs productive viral replication in infected cells.
Compete or Coexist? Why the Same Mechanisms of Symmetry Breaking Can Yield Distinct Outcomes
Authors: Goryachev Andrew B. , Leda Marcin
Published: September 2020

Cellular morphogenesis is governed by the prepattern based on the symmetry-breaking emergence of dense protein clusters. Thus, a cluster of active GTPase Cdc42 marks the site of nascent bud in the baker’s yeast. An important biological question is which mechanisms control the number of pattern maxima (spots) and, thus, the number of nascent cellular structures. Distinct flavors of theoretical models seem to suggest different predictions. While the classical Turing scenario leads to an array of stably coexisting multiple structures, mass-conserved models predict formation of a single spot that emerges via the greedy competition between the pattern maxima for the common molecular resources. Both the outcome and the kinetics of this competition are of significant biological importance but remained poorly explored. Recent theoretical analyses largely addressed these questions, but their results have not yet been fully appreciated by the broad biological community. Keeping mathematical apparatus and jargon to the minimum, we review the main conclusions of these analyses with their biological implications in mind. Focusing on the specific example of pattern formation by small GTPases, we speculate on the features of the patterning mechanisms that bypass competition and favor formation of multiple coexisting structures and contrast them with those of the mechanisms that harness competition to form unique cellular structures.
Formative Evaluation of Open Goals: A UK Community-Based Multi-Sport Family Programme
Authors: Burton Leanne , Curran Kathryn , Foweather Lawrence
Published: September 2020

Community parks provide opportunities for physical activity (PA) and facilitate social interactions. This formative evaluation assesses the implementation of ‘Open Goals’ (OG), a novel multi-sport programme aiming to increase family PA and community cohesion, delivered weekly by Liverpool Football Club’s charitable foundation to local parks in Liverpool, North West England. Three Open Goals parks were chosen for the evaluation settings. Formative evaluation measures included: System for Observing Play and Recreation in Communities (SOPARC) observations (n = 10), direct session observations (n = 8), semi-structured interviews with Open Goals coaching staff (n = 3), and informal feedback from families (n = 5) about their experiences of Open Goals. Descriptive statistics and thematic analysis were applied to quantitative and qualitative data, respectively. Within the three evaluation parks, Open Goals reached 107 participants from May–July 2019, through 423 session attendances. Fidelity of the programme was high (M = 69% of session content delivered as intended). Overall park use when OG was offered compared to when it was not offered was not statistically significant (p = 0.051), however, target area use was significantly increased (p = 0.001). Overall physical activity levels in parks were significantly (p = 0.002) higher when Open Goals was being offered, compared to when it was not. Coaches reported that engagement in OG positively affected family co-participation and children’s behavioural development. Contextual issues included environmental and social barriers to programme engagement, including the co-participation element of the programme and criticism of the marketing of OG. It is evident that community-based multi-sport PA programmes endorsed by professional football clubs are well positioned to connect with local communities in deprived areas and to encourage PA and community engagement. This study suggests that such programmes may have the ability to improve park usage in specific areas, along with improving physical activity levels among families, although further research is required. Effective marketing strategies are needed for promotional purposes. Upskilling of coaches in the encouragement of family co-participation may support regular family engagement in PA in local parks.
Light Output Enhancement of GaN-Based Light-Emitting Diodes Based on AlN/GaN Distributed Bragg Reflectors Grown on Si (111) Substrates
Authors: Yang Yibin , Zhang Lingxia , Zhao Yu
Published: September 2020

Due to the absorption of opaque Si substrates, the luminous efficiency of GaN-based light-emitting diodes (LEDs) on Si substrates is not high. So, in this work, we insert AlN/GaN distributed Bragg reflectors (DBRs) to improve the light output of GaN-based LEDs on Si (111) substrates grown via metal organic chemical vapor deposition (MOCVD). In order to obtain the highest reflectivity of the AlN/GaN DBR stop band, the growth parameters of AlN/GaN DBRs are optimized, including the growth temperature, the V/III ratio and the growth pressure. As a consequence, the interfaces of the optimal 9-pair AlN/GaN DBRs become abrupt, and the reflectivity of the DBR stop band is as high as 85.2%, near to the calculated value (92.5%). Finally, crack-free GaN-based LEDs with 5-pair AlN/GaN DBRs are grown on Si (111) substrates. The light output of the DBR-based LED is evidently enhanced by 41.8% at the injection current of 350 mA, compared with the conventional DBR-based LED without DBRs. These results pave the way for the luminous efficiency improvement of future green and red GaN-based LEDs grown on Si substrates.
Structures and Properties of New Organic Conductors: BEDT-TTF, BEST and BETS Salts of the HOC2H4SO3− Anion
Authors: Akutsu Hiroki , Koyama Yuta , Turner Scott S. , Furuta Keigo , Nakazawa Yasuhiro
Published: September 2020

New bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF)-, bis(ethylenediseleno)tetrathiafulvalene (BEST)- and bis(ethylenedithio)tetraselenafulvalene (BETS)-based organic charge-transfer (CT) salts—α-(BEDT-TTF)3(HOC2H4SO3)2 (1), β-(BEST)3(HOC2H4SO3)2·H2O (2) and α-(BETS)2(HOC2H4SO3)·H2O (3)—have been prepared. Salts 1 and 2 show semiconducting behaviour. Salt 3, which is almost isostructural to α-(BETS)2I3, shows metallic behaviour down to 70 K and then shows a broader metal–insulator transition than that of α-(BETS)2I3. The reason for the difference in behaviour is estimated by the comparison of the Madelung energies of the full set of patterns of possible donor’s charge-ordered and anion’s disordered states.
Optimization of Deep Learning Network Parameters Using Uniform Experimental Design for Breast Cancer Histopathological Image Classification
Authors: Lin Cheng-Jian , Jeng Shiou-Yun
Published: September 2020

Breast cancer, a common cancer type, is a major health concern in women. Recently, researchers used convolutional neural networks (CNNs) for medical image analysis and demonstrated classification performance for breast cancer diagnosis from within histopathological image datasets. However, the parameter settings of a CNN model are complicated, and using Breast Cancer Histopathological Database data for the classification is time-consuming. To overcome these problems, this study used a uniform experimental design (UED) and optimized the CNN parameters of breast cancer histopathological image classification. In UED, regression analysis was used to optimize the parameters. The experimental results indicated that the proposed method with UED parameter optimization provided 84.41% classification accuracy rate. In conclusion, the proposed method can improve the classification accuracy effectively, with results superior to those of other similar methods.
Revenue Sharing and Collusive Behavior in the Major League Baseball Posting System
Authors: Rockerbie Duane W.
Published: September 2020

This paper uses auction theory to explain the unique design of the 1998–2013 posting system agreed to between Major League Baseball and the Japanese Nippon Professional Baseball League that allowed for the transfer of baseball players from Japan to the United States. It has some similarities and many differences from the transfer system used to obtain players in European football. The unique features of the posting system were a compromise between Major League Baseball clubs and Nippon Professional Baseball clubs with the understanding that the former was a collusive group of club owners. Revenue sharing is a method to enforce a system of side payments to collusive bidders. It is then profit-maximizing to have the bidder with the highest net surplus from the player win the auction. Changes to the revenue sharing system used in Major League Baseball reduced the ability of club owners to bid for Japanese players, hence changes to the bidding rules of the posting system coincided at the same time.
A Short-Term Air Quality Control for PM10 Levels
Authors: Carnevale Claudio , De Angelis Elena , Tagliani Franco Luis , Turrini Enrico , Volta Marialuisa
Published: September 2020

In this work, the implementation and test of an integrated assessment model (IAM) to aid governments to define their short term plans (STP) is presented. The methodology is based on a receding horizon approach where the forecasting model gives information about a selected air quality index up to 3 days in advance once the emission of the involved pollutants (control variable) are known. The methodology is fully general with respect to the model used for the forecast and the air quality index; nevertheless, the selection of these models must take into account the peculiarities of the pollutants to be controlled. This system has been tested for particulate matter (PM10) control over a domain located in Northern Italy including the highly polluted area of Brescia. The results show that the control system can be a valuable asset to aid local authorities in the selection of suitable air quality plans.
Emotional Variability Analysis Based I-Vector for Speaker Verification in Under-Stress Conditions
Authors: Prasetio Barlian Henryranu , Tamura Hiroki , Tanno Koichi
Published: September 2020

Emotional conditions cause changes in the speech production system. It produces the differences in the acoustical characteristics compared to neutral conditions. The presence of emotion makes the performance of a speaker verification system degrade. In this paper, we propose a speaker modeling that accommodates the presence of emotions on the speech segments by extracting a speaker representation compactly. The speaker model is estimated by following a similar procedure to the i-vector technique, but it considerate the emotional effect as the channel variability component. We named this method as the emotional variability analysis (EVA). EVA represents the emotion subspace separately to the speaker subspace, like the joint factor analysis (JFA) model. The effectiveness of the proposed system is evaluated by comparing it with the standard i-vector system in the speaker verification task of the Speech Under Simulated and Actual Stress (SUSAS) dataset with three different scoring methods. The evaluation focus in terms of the equal error rate (EER). In addition, we also conducted an ablation study for a more comprehensive analysis of the EVA-based i-vector. Based on experiment results, the proposed system outperformed the standard i-vector system and achieved state-of-the-art results in the verification task for the under-stressed speakers.
Developing an Open-Source Lightweight Game Engine with DNN Support
Authors: Park Haechan , Baek Nakhoon
Published: September 2020

With the growth of artificial intelligence and deep learning technology, we have many active research works to apply the related techniques in various fields. To test and apply the latest machine learning techniques in gaming, it will be very useful to have a light-weight game engine for quick prototyping. Our game engine is implemented in a cost-effective way, in comparison to well-known commercial proprietary game engines, by utilizing open source products. Due to its simple internal architecture, our game engine is especially beneficial for modifying and reviewing the new functions through quick and repetitive tests. In addition, the game engine has a DNN (deep neural network) module, with which the proposed game engine can apply deep learning techniques to the game features, through applying deep learning algorithms in real-time. Our DNN module uses a simple C++ function interface, rather than additional programming languages and/or scripts. This simplicity enables us to apply machine learning techniques more efficiently and casually to the game applications. We also found some technical issues during our development with open sources. These issues mostly occurred while integrating various open source products into a single game engine. We present details of these technical issues and our solutions.
Assessing the Social Sustainability Indicators in Vernacular Architecture—Application of a Green Building Assessment Approach
Authors: Olukoya Obafemi A. P. , Atanda Jubril O.
Published: September 2020

Although a growing body of research has debated the array of sustainability lessons of vernacular architecture, social sustainability discussions remain less advanced in comparison to the other pillars of sustainability. This has narrowed the plural lessons of vernacular architecture and limited the broad concept of sustainability to a partial one. Against this research gap, this study aims to conduct an assessment of the social sustainability of residential vernacular architecture through the application of a proposed Social Criteria of Green Building Assessment Tool (SCGBAT) assessment method. The SCGBAT proposes eight sets of social criteria categories namely; health and safety; participation and control; education; equity, accessibility and satisfaction; social cohesion; cultural values; physical resilience and also, 37 indicators for the evaluation of social sustainability. To empirically operationalize the proposed SCGBAT, this study utilizes the vernacular architecture typologies in the vernacular landscape of Louroujina village in Cyprus as a case study. Methods for data collection are desk review for secondary data while 135 close-ended questionnaires were used for primary data. The data are statistically presented based on Linkert scale and interpreted using both quantitative and descriptive analysis. The results demonstrated that the investigated vernacular architecture ranked lowly in Physical Resilience Indicator (PRI), Environmental Education Indicator (EEI), Accessibility and Satisfaction Indicator (ASI) but demonstrated sufficient lessons in the context of Health and Safety Indicator (HSI); Participation and Control Indicator (PCI); Social Equity Indicator (SEI); Social Cohesion Indicator (SCI); and Cultural Value Indicator (CVI). To this end, this paper contribute to the advancement of knowledge on the assessment of the social sustainability of vernacular architecture by innovatively applying a green building assessment approach and identifying the strengths and weaknesses of such approach in a vernacular setting.
Integrating Plant Diversity Data into Mapping and Assessment of Ecosystem and Their Services (MAES) Implementation in Greece: Woodland and Forest Pilot
Authors: Kotsiras Konstantinos , Kokkoris Ioannis P. , Strid Arne , Dimopoulos Panayotis
Published: September 2020

Research Highlights: This is the first approach that integrates biodiversity data into Mapping and Assessment of Ecosystem and their Services (MAES) implementation and natural capital accounting process, at the national scale, using an extensive vascular plant dataset for Greece. Background and Objectives: The study aims to support the MAES implementation in Greece, by assessing, as a pilot, the woodland and forest ecosystem type; the targets of the study are: (a) Identify and map ecosystem type extent; (b) identify ecosystem condition using biodiversity in terms of plant species richness (i.e., total, ecosystem exclusive, endemic, ecosystem exclusive endemic diversity); (c) develop ecosystem asset proxy indicators by combining ecosystem extent and ecosystem condition outcomes; (d) identify shortcomings; and (e) propose future steps and implications for the MAES implementation and natural capital accounting, based on biodiversity data. Materials and Methods: Following the national European Union’s and United Nations System of Environmental Economic Accounts-Experimental Ecosystem Accounting (SEEA-EEA) guidelines and the adopted National Set of MAES Indicators, we developed a set of four proxy ecosystem asset indicators to assess ecosystem types with respect to ecosystem area extent and ecosystem condition. This was as interpreted by its plant diversity in terms of species richness (total, ecosystem exclusive, endemic, and ecosystem exclusive endemic diversity). Results: The results revealed that when indicators use well-developed biodiversity datasets, in combination with ecosystem extent data, they can provide the baseline for ecosystem condition assessment, ecosystem asset delineation, and support operational MAES studies. Conclusions: The relation among biodiversity, ecosystem condition, and ecosystem services is not a linear equation and detailed, fine-scale assessments are needed to identify and interpret all aspects of biodiversity. However, areas of importance are pinpointed throughout Greece, and guidance is provided for case-study selection, conservation strategy, and decision-making under the perspective of national and EU environmental policies.
Development of Downy Birch (Betula pubescens Ehrh.) Coppice Stands during Nine Years
Authors: Hytönen Jyrki
Published: September 2020

Growing of dense, naturally regenerated downy birch stands using rotations of 24–26 years has been shown to be profitable. Coppicing would be a low-cost regeneration method, however, knowledge on the development of birch coppices is scarce. The height, stem number, and biomass development of sprouts originating from six clearcut stands in three age classes (A: 10–12 years, B: 15–16 years, C: 22–24 years) located in northern Finland was studied. Equations for estimating the aboveground biomass from height were developed for sprouts. The number of sprouts, and their height and biomass were measured annually during nine growing seasons. In addition, sprout damage was assessed. The number of sprouts per hectare was highest in the youngest age class (A) throughout the study period, even though the decrease in the number of stems due to self-thinning was also fastest (from 591,000 sprouts per ha to 105,000 sprouts per ha). The stand age class did not have an effect on either the mean (2.7 m) or dominant height (5.4 m) of birch sprouts. The total leafless above-ground biomass, the mean annual increment (MAI), and the current annual increment (CAI) were highest in the youngest stand age class (A) and lowest in the oldest age class (C). After 9 years, the biomass in the oldest age class was 15.1 Mg ha−1 and 31.1 Mg ha−1 in the youngest age class. During the first six years, the biomass of the sprouts correlated with the number of stumps. A higher number of stumps produced more sprouts and biomass in the first years. However, due to faster self-thinning in the densest stands and higher mass of average sprout in the oldest stands, the correlation between the number of stumps and biomass decreased with the increase of age so that it was no longer significant in years 7, 8, and 9. In the older stand age classes, the MAI increased with the increase of the age of sprouts. The CAI varied considerably between the study years. The study showed that due to coppice vigor, growth of the birch sprouts can be high.