bluuebunny/crossref_metadata_2025 huggingface dataset:
Mobile Medienpraktiken im Spannungsfeld von Öffentlichkeit, Privatheit und Anonymität
Authors: König Katharina , Oloff Florence
Published: January 2021

This contribution aims to describe privacy, publicness and anonymity as essential dimensions for doing media linguistics. These dimensions are not inherent in and predetermined by the technical features and forms of communication, but are used by the participants as an orientation grid for shaping their online and offline practices in and with mobile media. Considering both mobile media use in the public realm and the dissemination of increasingly private content in social media (which is said to lead to ‘blurred boundaries’ between the private and the public), this paper provides a brief overview of the main developments in mobile media research. Studies adopting various approaches – e.g. sociological-ethnographic, linguistic and media studies – illustrate how privacy, publicness and anonymity are actively shaped and brought about by mobile media users. These observations indicate that the concepts of privacy and publicness have not lost their meaning but media linguistics should study the emergence of new multimodal practices by which they are framed and accomplished.
Der Einfluss extremistischer Gewaltereignisse auf das Framing von Extremismen auf SPIEGEL Online
Authors: Czulo Oliver , Nyhuis Dominic , Weyell Adam
Published: January 2021

In this article, we examine the representation of right-wing extremism, left-wing extremism and Islamism in the media-public discourse using the example of SPIEGEL Online, one of the leading German media. We derive four central dimensions for the conceptualization of extremisms: ideological foundation, origin of the actors, position towards society and typical actions. We observe the development of the representation of extremisms at potential breakpoints: We investigate the associative framing of the extremisms before and after a prominent extremism-related violent event, namely 9/11, the publication of the NSU scandal and left-wing extremist activities during the G20 summit. We observe changes in framing motivated by the selected events and compare the resulting framing with the current definitions of the Federal Office for the Protection of the Constitution, in order to work out possible differences in the conceptualization of extremism variants with potentially different logics of action to be expected from diverging conceptualisations.
Medial Shaping from the Outset: On the Mediality of the Second Presidential Debate, 2016
Authors: Luginbühl Martin , Schneider Jan Georg
Published: January 2021

In the present article we argue that all communication is medial in the sense that every human sign-based interaction is shaped by me­dial aspects from the outset. We propose a dynamic, semiotic con­cept of media that focuses on the process-related aspect of media­lity, and we test the applicability of this concept using as an example the second presidential debate between Clinton and Trump in 2016. The analysis shows in detail how the sign processing during the debate is continuously shaped by structural aspects of television and specific traits of political communication in television. This includes how the camerawork creates meaning and how the protagonists both use the affordances of this special mediality. Therefore, it is not adequate in our view to separate the technical aspects of the me­dium, the ‘hardware’, from the processual aspects and the structural conditions of communication. While some aspects of the interaction are directly constituted by the medium, others are more indirectly shaped and influenced by it, especially by its institutional dimension – we understand them as second-order media effects. The whole medial procedure with its specific mediality is a necessary, but not a sufficient condition of meaning-making. We distinguish the medial procedure from the semiotic modes employed, the language games played and the competence of the play­ers involved.
Hydrogen bonding systems in birch bark
Authors: Леонтьев Л.Л. , Лобок И.Д. , Иванов-Омский В.И. , Смолин А.С.
Published: January 2021

Произведено сравнение систем водородных связей во внешнем и внутреннем слоях березовой бересты, в сравнении с водородными связями в высококачественной бумаге и в образце выделенной из древесины целлюлозы. Интервал исследуемых частот от 3000 до 3700 см-1, ограничен областью поглощения гидроксильными ОН-группами, частоты которых наиболее чувствительны к возникновению Н-связей. Для оценки параметров Н-связей проводилась деконволюция полос поглощения ОН-групп гауссовыми компонентами. Для корректного выделения поглощения гидроксильными группамипервоначально деконволюции подвергается весь фрагмент, включающий в себя полосы поглощения как метиленовым, так и гидроксильными группами. В дальнейшем анализировались только параметры контуров деконволюции, относящейся к гидроксильным группам. Принималось, что каждый компонент деконволюции может быть ассоциирован с определенным типом водородной связи. Определялся сдвиг частот компонентов деконволюции относительно собственной частоты колебаний изолированной гидроксильной группы, не охваченной по этой причине водородной связью. Для определения энергии водородных связей использовались литературные данные по корреляции энергии водородной связи с частотным сдвигом. Относительная плотность водородных связей оценивалась по отношению площадей контуров деконволюции.

A comparison was made of the hydrogen bond systems in the outer and inner layer of birch bark, as well as a comparison of high-quality paper with a sample of pure pulp. The range of frequencies under study from 3000 to 3700 cm-1 is limited by the absorption region by hydroxyl OH groups, the frequencies of which are most sensitive to the occurrence of H bonds. To estimate the parameters of H-bonds, the absorption bands of OH groups were deconvolved by Gaussian components. In order to correctly isolate the absorption by hydroxyl groups, the entire fragment, whichincludes absorption bands of both methylene and hydroxyl groups, is initially deconvolved. In the future, only the parameters of the deconvolution contours related to hydroxyl groups were analyzed. It was assumed that each component of deconvolution can be associated with a certain type of hydrogen bond. The frequency shift of the components of the deconvolution was determined relative to the natural frequency of vibrations of the isolated hydroxyl group, which is therefore not covered by a hydrogen bond. To determine the energy of hydrogen bonds, we used literature data on the correlation of the hydrogen bond energy with a frequency shift. The relative density of hydrogen bonds was estimated by the ratio of the area of the contours of deconvolution.
Polymer composite material based on terpenoid raw materials for the production of plastic skis
Authors: Латышевич И.А. , Гапанькова Е.И. , Полховский А.В. , Бильдюкевич А.В. , Шетько С.В. , Прохорчик С.А. , Клюев А.Ю. , Козлов Н.Г.
Published: January 2021

В настоящее время лыжный спорт пользуется большой популярностью, поэтому спрос на лыжи постоянно возрастает. В связи с чем развитиенационального лыжестроения является актуальным для нашей страны направлением. Лыжная индустрия развивается быстрыми темпами и на смену деревянным лыжам пришли пластиковые. Одним из составляющих компонентов лыж является полимерный композиционный материал (препрег). Поэтому сейчас производство препрега набирает обороты, создаются новые материалы на их основе. Проведенные исследования позволили разработать рецептуру и лабораторную технологию связующего на основе вторичных терпеноидных продуктов для изготовления препрега с дальнейшим использованием его при производстве пластиковых лыж. Полученные экспериментальные образцы лыж на производственных площадях филиала «Телеханы» Республиканского производственно-торгового унитарного предприятия «Беларусьторг» Управления делами Президента Республики Беларусь, по своим эксплуатационным свойствам находятся на уровне нормативных показателей.

Currently, skiing is very popular. Therefore, the demand for skis is constantly increasing. The development of the national ski industry is an important direction for our country. The ski industry is developing rapidly and plastic skis have replaced wooden skis. One of the components of skis is a polymer composite material (prepreg). Therefore, now the production of prepreg is increasing, many new materials on its basis are created. Our research has allowed us to develop a formulation and laboratory technology of a binder based on secondary terpenoid products for the production of prepreg for its further use in the production of plastic skis. Experimental samples of skis obtained at the production arears of the «Telehany» of the Republican production trade unitary enterprise «Belarustorg» of the administrative department of the President of the Republic of Belarus are at the level of standard indicators for their operational properties.
Software TLB Management Method Based on Balanced Binary Tree
Authors: Chen Hongyu , Zhao Li , Zhang Yuke , Ai Jian
Published: January 2021

Purpose: with the development of the computer system, there is a higher request to reduce the failure times of Translation Look—aside Buffer and relieve the failure influence, normal solution is deal with TLB failure by software or hardware, it find the page table and then implement the index operation to locate the page want. Method: In order to satisfy the needs of software management method for mapping speed from virtual address to physical address and to expand the size of TLB, our team design a software management method based on balanced binary search tree. Page management is implemented in software management, TLB is managed by operating system based on abstract model, and MMU (memory management unit) is no longer used Unit, our team build a balanced binary tree to search TLB. Result: Binary search tree has the advantage of pruning in the interval search problem under the balanced state. Therefore, searching TLB by this method is conducive to the expansion of TLB capacity, making space for cache and other performance improvement designs on chip and reducing costs. However, the search speed is reduced and some time is sacrificed to free up CPU space. Conclusion: This method can free up CPU design space, also can expand more size of TLB and reduce the cost, its optimization algorithm is worthy of further research.
Conditional GAN-based Remote Sensing Target Image Generation Method
Authors: Liu Haoyang , Hu Zhiyi , Yu Jun , Gao Shouyi
Published: January 2021

In view of the uncontrollable process of traditional GAN generating remote sensing target images, the shortcomings of generated samples are similar, and lack diversity. This paper proposes a generative confrontation network model based on background conditions. First, the computer vision attention mechanism is introduced into the generative confrontation network. Choose a learning target model so that the GAN network only learns the target model during training, and ignores other non-target information. Reduce the dependence on the number of samples in the GAN training process; secondly, use the U-net network as a generator to restore other non-target information when generating the remote sensing image of the target as much as possible; again, distinguish by different colors of the conditional mask The category of the generated target; at the same time, the L1 regularization loss is added to the loss term of the generator model, and finally, the remote sensing target image is generated. The experimental results show that the peak signal-to-noise ratio (PSNR) of the remote sensing image generation algorithm proposed in this paper reached 18.512, and the structural similarity (SSIM) reached 88.47%, which is better than the comparison test model where the generator is an ordinary autoencoder.
Imperative to Build Network Security System and Speed Up the Future Network Construction
Authors: Wu Aiqun , Gao Zhangxing
Published: January 2021

Network security is a comprehensive discipline involving computer science, network technology, communication technology, cryptography, information security technology, applied mathematics, number theory, information theory and other disciplines. Network security is to protect the hardware, software and data in the network system from accidental or malicious damage, change, and disclosure. The system runs continuously and reliably and normally, and network services are not interrupted. Although network security in the future market prospect is very good, but the Internet structural defects are known, because in the past nearly 20 years of rapid development of Internet technology, the pioneers of the IT industry seems to be technology focuses on the network flexibility and ignore the security of the network, so, in the site after the loss of a large number of network attacks, network security technology becomes emergent vacuum in the information technology, for the maintenance of computer network system security maintenance, inspection and repair network vulnerabilities, virus protection, organized by the national high strength against network has serious threat to all countries in the world, In such an environment, the core technology, key infrastructure is the only rely on independent innovation, create a new network system, with the new architecture, a new design, new technology, new resources, new standard and new application to open up a new network space, the building has an independent sovereign and independent control system of network security, it is imperative to accelerate the future network development.
Psychological Support for People with Drug-Related Disorders at the Stage of Rehabilitation
Authors: Ivanova A. V.
Published: January 2021

The article presents the performance indicators of the drug treatment service in the Russian Federation. The incidence of cannabinoid and designer drugs is growing, and so is the so-called poly-drug addiction. Thus, the value-semantic sphere of the personality of patients with poly-drug addiction requires more extensive research. The present study proved that such patients have very low awareness of personal experiences, current life situation, and goals. The poly-drug patients demonstrated a diffuse hierarchy of value orientations and a low level of comprehension of the past, present, and future values. Their valuesemantic sphere was of a malignant nature and collapsed much faster than in patients with alcoholism. The paper focuses on the psychological support of patients with drug-related disorders at the stage of rehabilitation. As part of tertiary prevention, the program of psychological support can be based on methodological principles of the value-semantic sphere of personal development. This approach makes it possible to focus the rehabilitation process on rethinking the values of personal experience, real-life situation, and future goals. The article also introduces various levels of psychological assistance, based on the rehabilitation program realized at the Kuzbass Clinical Narcological Dispensary.
Examining the Psychometric Characteristics of the Subjective Evaluation of Basic Values Realizability (SEBVR) Technique Designed for Value Orientation Studies
Authors: Filenko I. A. , Atamanova I. V. , Bogomaz S. A.
Published: January 2021

The article addresses the issues associated with increasing the reliability of research tools for value orientation studies. Despite the high demand, their methodology requires qualitative improvement. The research objective was to determine the psychometric characteristics of the Subjective Evaluation of Basic Values Realizability (SEBVR) technique. The study was based on the SEBVR technique and the Portrait Values Questionnaire-Revised (PVQ-R) by Schwartz. The data processing included factor analysis, correlation analysis, reliability analysis, the Kolmogorov-Smirnov test, and the Mann-Whitney U-test. The analysis involved 1,415 respondents aged 17–29. The authors clarified the factor structure of the SEBVR technique as represented by four scales. They evaluated the reliability characteristics of the internal consistency of the scales, their construct validity, and descriptive statistics for the main SEBVR indicators. The technique proved efficient in identifying differences between male and female respondents. According to its psychometric characteristics, the SEBVR technique appeared to be a fairly reliable research tool, which makes it possible to expand the possibilities of its use in applied research related to exploring young adults’ value orientations in the age group of 17–29 years.
The Associative Dictionary of Media Events in the Early XXI Century: a New Lexicographic Concept
Authors: Dudareva Ya. A. , Shpilnaya N. N. , Moskvitina T. V.
Published: January 2021

The article introduces a new concept of the Associative Dictionary of Media Events of the Early XXI Century. The project continues the traditions of common lexicography. As a rule, common lexicography is part of a special problem field described by various antinomies, e.g. objective vs. subjective in the language, individual vs. collective, descriptive vs. prescriptive approaches to the lexical representation in dictionaries, etc. The new dictionary represents a snapshot of everyday media consciousness and thus belongs to descriptive lexicographic projects. The dictionary is based on an associative experiment that involved Russian and French speakers. While traditional associative dictionaries contain the most frequent vocabulary, this project represents the conceptual meanings of various media events that exist in the everyday collective consciousness. The new dictionary belongs to media linguistics, descriptive lexicography, and interpretive linguistics. The present article describes the technology of its compilation, substantiates its relevance and novelty, and offers a sample entry using the case of the COVID-19 pandemic and its representation in the Russian language. Each media event consisted of two associative nests: one was based on the reactions of respondents who were familiar with the stimulus, whereas the other demonstrated reactions of participants unfamiliar with the media event. The epidemic being global, such key lexemes as "covid" and "coronavirus" lost their agnonymity for Russian speakers, and the media event appeared to have a zero agnonymous associative nest. The paper also provides a linguistic commentary on the covid entry, which summed up all the reactions received during the associative experiment. The lexicographic project can be of interest to specialists in media, political, cognitive, and cultural linguistics.
Nikolay Grech’s Rhetorical Teaching as a Tool of Text Analysis
Authors: Makarova L. E.
Published: January 2021

Russian rhetoric began with Mikhail Lomonosov’s Brief Guide to Eloquence (1765), which was written in the classical tradition of the Aristotelian-Ciceronian teaching about effective and persuasive speech. By the time philology had become a unified knowledge system in 1820s, Russian rhetoric stopped being a part of the trivium of verbal sciences, which also included grammar and logic, and evolved into a theory of language arts [slovesnost] that included both fiction and nonfiction literature. Its focus shifted from statement building to development and classification of the existing types and genres of literature. The science gave birth to a new discipline, namely the history and theory of literature, Nikolay Grech being one of its founders. Thus, the subject of rhetoric was mostly the principles of understanding of written fiction. Grech’s concept reflected those new trends in the development of rhetoric while focusing on the analysis of the system of Russian literature as a whole. The present research employed the methods of comparative analysis and analytical interpretation of the text. The article introduces N. Grech’s ideas about rhetorical and fictional prose, as well as his classification of prose and poetry. The author showed how the emergence of borderline, semi-rhetorical, and semi-poetic genres, changed the relationship between prose and poetry and, accordingly, between rhetoric and poetics. From a tool for creating an utterance, rhetoric gradually became a tool for analyzing a finished text.
Media Genres and Compositional Speech Forms of Journalism: Relationships and Connections
Authors: Pastukhov A. G.
Published: January 2021

The existing set of media text modifications with their numerous contexts remains largely understudied in terms of text typology. There are no complex descriptions of the types of media messages. The article raises the problem of correlation between media genres and the compositional speech forms of journalism. The author interprets compositional speech forms as complex functional textual units that structure the thought and give it integrity and completeness. Genre approaches to classifications and current media text typology issues dominate in the contemporary text linguistics, despite the fact that the genre remains its central category. The Germanic studies have accumulated enough experience to generalize the existing points of view and cover all possible journalistic representation forms (journalistische Darstellungsformen). From the standpoint of text linguistics, it is the genre variety of media proposals that confirms the priority of the term Textsorte, which covers homogeneous text classes that are hierarchically the same. This article focuses on the term Textsorte, since it covers the whole variety of media genres and fixes the hierarchical principle of the text function in the system of communicative speech classifications. Therefore, Textsorte is the main operational reference point in German genre studies and the basis for multidimensional classifications of media texts.
Literary Concept of Dog: Dog’s Death Scenario in American Mass Fiction
Authors: Rabkina N. V. , Valko O. V.
Published: January 2021

The present research featured the dog’s death scenario in twentieth-century American mass fiction based on Robert McCammon’s novels. The authors believe that the popularity of this scenario has its roots in mythology and precedent texts of the linguaculture in question. In global mythology, dogs dwell in the twilight zone between the world of the living and the world of the dead. Modern mass literature preserved this function of the dog as a guide into the other world. As a child extrapolates the episode of their pet’s death, they enter the threshold situation that triggers the awareness of their own death, thus providing access to experience available only at subconscious level. The authors review scientific publications that feature the concept of dog, give classical examples of American literature that shaped the etalon scenario of a dog’s death, and support them with episodes from R. McCammon’s works "Where the Red Fern Grows". Modern mass fiction adopted the etalon scenario of a dog’s death from a story by Wilson Rawls. This scenario presupposes obligatory stages of acceptance and coming-of-age. Any modifications of the etalon scenario result in stagnation or death of the personage.
Agrotechnical Prerequisites of the Stolypin Agrarian Reform
Authors: Belyanin D. N.
Published: January 2021

The present research featured the agrotechnical prerequisites of the agrarian reform introduced by P. A. Stolypin. The article focuses on the agrotechnical crisis in the rural Russian in the post-reform period. However, the complex and debatable matter of the effect of the community on the crisis was beyond the scope of the study. The author believes that the crisis of the three-field system was connected with the natural population increase and the agricultural overpopulation. The paper describes the methods used by Russian farmers to deal with the lack or agricultural lands and reveals their extensive nature. The author summarized and analyzed options for overcoming the agrotechnical crisis proposed by various state, political, and public figures in the late XIX century. A radical modernization of the Russian village was necessary to overcome the agrotechnical crisis and move on to intensive production forms, and the state policy should have become the instrument of that modernization. The agrarian reform conducted by P. A. Stolypin proved to have some agrotechnical prerequisites.
A Review on "Mountain Shoria: From Ancient Metallurgy to Modern Mining Industry. Historical Essays" by A. I. Kopytov and V. M. Kimeev (Kemerovo: Primula, 2020. 432 p.)
Authors: Konovalov A. B.
Published: January 2021

The review assesses the significance of A. I. Kopytov and V. M. Kimeev’s new monograph dedicated to the development of Mountain Shoria and its indigenous people – the Shor ethnos. The monograph describes the stages of the development of the Shor people, as well as the local administrative and territorial transformations. It gives a retrospective of Shoria as an object of scientific research and outlines the problem of the local industrial development. The authors assessed the prospects of museumification of the historical and cultural heritage. The present review compares A. I. Kopytov and V. M. Kimeev’s contribution to the study of Mountain Shoria with that of their predecessors and states the apparent value of the monograph.
Latent Profiles Analysis of Personal Determinants of Overcoming Adversity (Russian and Uzbek Samples)
Authors: Vecherin A. V.
Published: January 2021

The article introduces an analysis of latent profiles of personal determinants of overcoming adversity. The research included 989 Russian respondents aged 18–78 years and 272 Uzbek respondents aged 18–48. The study involved the following methods: Proactive Coping Questionnaire (PCI), Uncertainty Tolerance Questionnaire (MSTAT–II), Positive and Negative Emotions Questionnaire (PANAS). The statistical analysis of latent profiles (LPA) made it possible to describe the best model, which included five latent profiles. This model demonstrated similar profiles in the Russian and Uzbek samples. Profiles with high proactive, reflexive, preventive coping, and strategic planning values accompanied by low social and emotional support values, had a high level of positive and low values of negative decompensation. Profiles with low proactive, reflexive, preventive coping, and strategic planning values combined with high social and emotional support values were associated with high problem avoidance, low tolerance to uncertainty, and a negative decompensation.
1º FÓRUM DE PESQUISA DISCENTE DO PROGRAMA DE PÓS-GRADUAÇÃO EM GESTÃO E ORGANIZAÇÃO DO CONHECIMENTO DA UFMG: RELATO DE EXPERIÊNCIA
Authors: Emygdio Jeanne Louize , Cunha Izabella Bauer de Assis , Almeida Maurício Barcellos
Published: January 2021

Relata-se a experiência de realização do 1º Fórum de Pesquisa Discente do Programa de Pós-Graduação em Gestão e Organização do Conhecimento, Universidade Federal de Minas Gerais - UFMG, Escola de Ciência da Informação. A iniciativa visava agregar qualidade às práticas de pesquisa em nível stricto sensu, a partir do fomento ao diálogo em torno das pesquisas em andamento. São resultados obtidos: maior percepção de oportunidades de pesquisa na área; ampliação da rede de pesquisadores; fomento ao diálogo entre os grupos de pesquisa; maior preparo para participação em eventos externos; avaliação crítica das pesquisas antes das qualificações e defesas.
REPOSITÓRIO INSTITUCIONAL DA UFBA: VISIBILIDADE DAS PRODUÇÕES ACADÊMICAS DOS GRADUADOS
Authors: Santos Davilene Souza , Rosa Flávia Goulart Mota Garcia
Published: January 2021

Este artigo visa verificar a disponibilização de conteúdo das produções acadêmicas dos alunos graduados no Repositório Institucional da Universidade Federal da Bahia. O repositório possibilita alavancar a visibilidade dos documentos produzidos por esses estudantes, de modo que estimule a produção de conhecimento no âmbito dos cursos de graduação, atendendo aos princípios da comunicação científica em meio digital. Percebe-se que há diversos meios de disseminação para as teses e dissertações, contemplando a produção dos discentes de pós-graduação, a exemplo da Biblioteca Digital de Teses e Dissertações, mantida pelo Instituto Brasileiro de Informação em Ciência e Tecnologia, e da Plataforma Sucupira da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Os Repositórios Institucionais se apresentam como um importante canal para a disseminação da comunicação científica através dos Trabalhos de Conclusão de Curso dos graduandos, permitindo que o conhecimento produzido por eles seja compartilhado de forma ampla. A pesquisa descritiva se caracteriza por sua natureza aplicada, através de uma abordagem quali-quantitativa. Adotamos como procedimento de coleta de dados a observação sistemática do repositório e consulta ao representante do órgão gestor do repositório. Como resultado, verificamos que poucos cursos de graduação disponibilizam as produções dos graduados, já outros cursos não inseriram nenhum documento desse tipo. O levantamento dos dados permitiu concluir que ainda é incipiente a inserção de Trabalhos de Conclusão de Curso dos graduados, necessitando de um trabalho de incentivo junto aos coordenadores, docentes e discentes dos cursos de graduação e normativas para esta inserção, bem como maior clareza nas orientações do Repositório da Instituição quanto a disponibilização dessa produção.
OLHAR O BIBLIOTECÁRIO DO PRESENTE, VISUALIZAR A BIBLIOTECA DO FUTURO: ALFA E ÔMEGA, CÂMBIOS QUE FAZEM UMA BIBLIOTECA ESCOLAR
Authors: Carvalho Sandra Maria Souza de , Silveira Rogério Zanon da , Miguel Marcelo Calderari
Published: January 2021

Averiguar a representação do bibliotecário do presente e a biblioteca do futuro perante a Geração Alpha é um desafio provocador, envolve explorar nuances e compreender suas determinantes locais. O objetivo desse estudo é situar a imagem do bibliotecário do presente e a representação da biblioteca escolar do futuro, ambos os perfis comunicados na ótica dos novos nativos digitais. O método de análise parte da entrevista semiestruturada com os discentes Alphas da Umef Dr Tuffy Nader, na cidade de Vila Velha, ES. O roteiro de diagnóstico serve como instrumento para análise do Discurso do Sujeito Coletivo (DSC) e, visa pautar construtos como: i) o significado, a representação que define o Ser bibliotecário; e, ii) o prospectar de cenários para a nova biblioteca escolar do futuro. Logo, a abordagem é descritiva e analítica, fundamenta-se na análise de discurso com apoio tecnológico do software DSCSoft. Os resultados evidenciam novos tempos e hábitos para a biblioteca escolar e o profissional da informação; pauta os dilemas de utopias, distopia e retrotopia que a cultura digital e as tecnologias de informação geram. O trabalho destaca a necessidade permanente da inovação dos modernos profissionais da informação (MPI) na ambiência da biblioteca e fora dela, e diz que a missão profissional se pauta no conhecimento científico e tecnológico, alinhado a valores humanos, para o exercício pleno da cidadania, com ética.
miRNA as Regulators of Prostate Carcinogenesis and Endocrine and Chemoresistance
Authors: Culig Zoran
Published: January 2021

More therapy options are available for advanced prostate cancer, including novel inhibitors
of androgen synthesis, anti-androgens, chemotherapeutics and targeted therapies. Although patients
´ survival has been improved, management of castration therapy-resistant prostate cancer remains
a challenge. Regulation of cellular events in cancer by small non-coding miRNAs is, therefore,
an area of special interest. Overexpression of selected miRNA may lead to androgen independence
and prostate cancer progression. miRNA may be considered also a biomarker in patients
with prostate cancer. In contrast, diminished expression of tumor-suppressive miRNA in prostate
cancer leads to enhanced proliferation, reduced apoptosis, increased migration, invasion and epithelial-
to-mesenchymal transition. miRNA may be directly involved in the regulation of chemosensitivity
in prostate cancer. Experimental overexpression of selected miRNA in chemoresistant prostate
cancer leads to the inhibition of cellular stemness and epithelial-to-mesenchymal transition. Reduction
of tumor-suppressive miRNA may also lead to hyperactivity of signaling pathways such as
that of the epidermal growth factor receptor and mitogen-activated protein kinase. Although considerable
progress on miRNA research in prostate cancer has been achieved, therapeutic effects could
be improved on the basis of the development of novel delivery methods.
Organic Antifungal Drugs and Targets of Their Action
Authors: Maksimov Alexander Yu , Balandina Svetlana Yu , Topanov Pavel A. , Mashevskaya Irina V. , Chaudhary Sandeep
Published: January 2021

In recent decades, there has been a significant increase in the number of fungal diseases. This is due to a wide spectrum of action, immunosuppressants and other group drugs. In terms of frequency, rapid spread and globality, fungal infections are approaching acute respiratory infections. Antimycotics are medicinal substances endorsed with fungicidal or fungistatic properties. For the treatment of fungal diseases, several groups of compounds are used that differ in their origin (natural or synthetic), molecular targets and mechanism of action, antifungal effect (fungicidal or fungistatic), indications for use (local or systemic infections), and methods of administration (parenteral, oral, outdoor). Several efforts have been made by various medicinal chemists around the world for the development of antifungal drugs with high efficacy with the least toxicity and maximum selectivity in the area of antifungal chemotherapy. The pharmacokinetic properties of the new antimycotics are also important: the ability to penetrate biological barriers, be absorbed and distributed in tissues and organs, get accumulated in tissues affected by micromycetes, undergo drug metabolism in the intestinal microflora and human organs, and in the kinetics of excretion from the body. There are several ways to search for new effective antimycotics:  - Obtaining new derivatives of the already used classes of antimycotics with improved activity properties.  - Screening of new chemical classes of synthetic antimycotic compounds.  - Screening of natural compounds.  - Identification of new unique molecular targets in the fungal cell.  - Development of new compositions and dosage forms with effective delivery vehicles.  The methods of informatics, bioinformatics, genomics and proteomics were extensively investigated for the development of new antimycotics. These techniques were employed in finding and identification of new molecular proteins in a fungal cell; in the determination of the selectivity of drugprotein interactions, evaluation of drug-drug interactions and synergism of drugs; determination of the structure-activity relationship (SAR) studies; determination of the molecular design of the most active, selective and safer drugs for the humans, animals and plants. In medical applications, the methods of information analysis and pharmacogenomics allow taking into account the individual phenotype of the patient, the level of expression of the targets of antifungal drugs when choosing antifungal agents and their dosage. This review article incorporates some of the most significant studies covering the basic structures and approaches for the synthesis of antifungal drugs and the directions for their further development.
Investigation of Adsorption Effect of Carbon Monoxide on Coniine:
A DFT Study
Authors: Shahab Siyamak , Sheikhi Masoome , Khaleghian Mehrnoosh , Murashko Marina , Ahmadianarog Mahin , Atroshko Mikhail
Published: January 2021

:

For the first time in the present study, the non-bonded interaction of the Coniine (C8H17N) with carbon monoxide
(CO) was investigated by density functional theory (DFT/M062X/6-311+G*) in the gas phase and solvent water. The
adsorption of the CO over C8H17N was affected on the electronic properties such as EHOMO, ELUMO, the energy gap between
LUMO and HOMO, global hardness. Furthermore, chemical shift tensors and natural charge of the C8H17N and complex
C8H17N/CO were determined and discussed. According to the natural bond orbital (NBO) results, the molecule C8H17N and
CO play as both electron donor and acceptor at the complex C8H17N/CO in the gas phase and solvent water. On the other
hand, the charge transfer is occurred between the bonding, antibonding or nonbonding orbitals in two molecules C8H17N
and CO. We have also investigated the charge distribution for the complex C8H17N/CO by molecular electrostatic potential
(MEP) calculations using the M062X/6-311+G* level of theory. The electronic spectra of the C8H17N and complex
C8H17N/CO were calculated by time dependent DFT (TD-DFT) for investigation of the maximum wavelength value of the
C8H17N before and after the non-bonded interaction with the CO in the gas phase and solvent water. Therefore, C8H17N can
be used as strong absorbers for air purification and reduce environmental pollution.
Cardiac MRI in Autoimmune Diseases: Where Are We Now?
Authors: Vallianou Natalia G. , Geladari Eleni , Panagopoulos Fotis , Kalantzi Maria
Published: January 2021

Cardiovascular magnetic resonance imaging (CMR) allows the early diagnosis of various cardiovascular
pathophysiologic phenomena in autoimmune diseases. Preliminary studies suggest that CMR holds a promising role in
initiating the necessary changes in anti-rheumatic and cardiac treatment among patients with autoimmune diseases and
cardiovascular diseases (CVD). It is widely known that the presence of late gadolinium enhancement (LGE) has been
related to worse cardiovascular prognosis. CMR has been documented to be the most valuable tool for diagnosis and risk
prediction of cardiac involvement in a sarcoidosis population, while in SLE, the gap between clinical and autopsy
diagnosis of myocardial disease could be narrowed with the implementation of CMR. In different connective tissue
diseases, including SLE, LGE has been demonstrated to be present, early after the initial diagnosis of SLE. Considering
that CMR including LGE identifies more patients with silent myocardial disease in SLE and other connective tissue
diseases than echocardiography, CMR should be the preferred imaging modality, especially in the era of modern
techniques with a broader availability and expertise. In this review, we summarize the major indications, advantages and
limitations of the use of CMR among patients with autoimmune disorders.
A Review on Deep Learning Architecture and Methods for MRI Brain Tumour Segmentation
Authors: Angulakshmi M. , Deepa M.
Published: January 2021

Background:

The automatic segmentation of brain tumour from MRI medical images is mainly covered in this
review. Recently, state-of-the-art performance is provided by deep learning-based approaches in the field of image
classification, segmentation, object detection, and tracking tasks.

Introduction:

The core feature deep learning approach is the hierarchical representation of features from images and thus
avoiding domain-specific handcrafted features.

Methods:

In this review paper, we have dealt with a Review of Deep Learning Architecture and Methods for MRI Brain
Tumour Segmentation. First, we have discussed basic architecture and approaches for deep learning methods. Secondly,
we have discussed the literature survey of MRI brain tumour segmentation using deep learning methods and its
multimodality fusion. Then, the advantages and disadvantages of each method analyzed and finally concluded the
discussion with the merits and challenges of deep learning techniques.

Results:

The review of brain tumour identification using deep learning.

Conclusion:

Techniques may help the researchers to have a better focus on it.
Intelligent Techniques Analysis for Glycosylation Site Prediction
Authors: Alkuhlani Alhasan , Gad Walaa , Roushdy Mohamed , Salem Abdel-Badeeh M.
Published: January 2021

Background:

Glycosylation is one of the most common post-translation modifications (PTMs) in organism
cells. It plays important roles in several biological processes including cell-cell interaction, protein folding, antigen’s
recognition, and immune response. In addition, glycosylation is associated with many human diseases such as cancer,
diabetes and coronaviruses. The experimental techniques for identifying glycosylation sites are time-consuming, extensive
laboratory work, and expensive. Therefore, computational intelligence techniques are becoming very important for
glycosylation site prediction.

Objective:

This paper is a theoretical discussion of the technical aspects of the biotechnological (e.g.,
using artificial intelligence and machine learning) to digital bioinformatics research and intelligent biocomputing.
The computational intelligent techniques have shown efficient results for predicting Nlinked,
O-linked and C-linked glycosylation sites. In the last two decades, many studies have been conducted
for glycosylation site prediction using these techniques. In this paper, we analyze and compare a
wide range of intelligent techniques of these studies from multiple aspects. The current challenges and
difficulties facing the software developers and knowledge engineers for predicting glycosylation sites
are also included.

Method:

The comparison between these different studies is introduced including many criteria such as
databases, feature extraction and selection, machine learning classification methods, evaluation
measures and the performance results.

Results and Conclusions:

Many challenges and problems are presented. Consequently, more efforts are needed to get
more accurate prediction models for the three basic types of glycosylation sites.
Therapeutic Potential of Poncirin Against Numerous Human Health Complications: Medicinal Uses and Therapeutic Benefit of an Active Principle
of Citrus Species
Authors: Patel Dinesh Kumar
Published: January 2021

:

Medicinal plants have been used in the indigenous system of medicine for the treatment of numerous human
health complications. Medicinal plants were used for the separation and isolation of pure phytochemical and some of the
best examples are tubocurarine, aspirin, morphine, digoxin, atropine, quinine and reserpine. Phytoconstituents are pure plant
derived natural chemical found to be present in the medicinal plants and examples are flavonoids, alkaloids and phenolic
compounds etc. In the modern medicine there is global growth of herbal medicines due to their nutrition, physical
effectiveness and pharmacological activities. Plants have been used in the traditional medicines and modern drug
discoveries program. In order to investigate the biological potential of poncirin in modern medicine, here different scientific
data have been analyzed in the present investigation through various literature sources. Detailed pharmacological activities
of poncirin were also investigated in the present investigation to reveal the medicinal properties of poncirin in the medicine
and other allied health sectors. Analytical techniques used for the isolation of poncirin from various medicinal plants have
been also presented in this study. Poncirin is a flavanone glycoside found to be present in the Poncirus trifoliata and Citrus
reticulate having bitter taste. Biological importance of poncirin for their anti-inflammatory activity through inhibition of
PGE2 and IL-6 production has been investigated in the scientific field. Biological importance of poncirin against bacterial,
viral infections, gastric disease and human gastric cancer has been investigated in the medicine. Pharmacological data
analysis revealed the biological application of poncirin against bone loss, inflammation, colitis, human gastric cancer,
gastritis, liver injury and alzheimer's disease. From the analysis of the presented scientific information of poncirin it was
found that poncirin have significant biological activities and health benefit in the modern health sectors for the treatment of
human health complications and could be used as a drug in the future.
Influence of Removable Denture Cleaning Agents on Adhesion of Oral Pathogenic Microflora In Vitro: A Randomized Controlled Trial
Authors: Volchkova I.R. , Yumashev A.V. , Borisov V.V. , Doroshina V.I. , Kristal E.A. , Repina S.I.
Published: January 2021

Introduction:

Removable dentures are used by 20% of the population. These may be accompanied by denture stomatitis in 15-70% of patients. The choice of the optimal cleansing agent for removable dental prostheses is of high significance.

Aim:

The aim of our research was to study the influence of removable denture cleansing products on the adhesion of microorganisms and yeast.

Materials and Methods:

We manufactured 144 specimens of standardized round shape with a diameter of 10 mm from 4 types of modern polymeric materials used by prosthetic dentistry to produce removable dentures, 12 specimens of each material were placed into suspensions of bacterial cultures of Staphylococcus aureus, Escherichia coli, Candida albicans, then into “ClearaSept” (Test group 1), “Рrotefix active cleanser” (Test group 2), saline solution (Control group), followed by nutrient media. The adhesion index was calculated and analyzed.

Results:

There was no reliable lowering of adhesion index of Staphylococcus Aureus to all materials detected in Test group 1 (U=6, p>0.05 for Bio XS; U=8, p>0.05 for Dental D, Denotokeep Peek, Vertex Rapid Simplified). In Test group 2, the adhesion index of Staphylococcus Aureus reliably decreased to all materials compared to the Control group (U=0, p≤0.01). The adhesion index of Candida albicans and Escherichia coli to all materials in Test group 1 had a minor to moderate reliable reduction compared to the Control group (U=0, p≤0.01). Test group 2 showed a significant reliable decrease in Candida albicans and Escherichia coli adhesion index to all materials in comparison with the Control group (U=0, p≤0.01).

Conclusion:

The research showed an unreliable or minor and moderate reliable decrease in microorganisms adhesion index depending on the microorganism species after treatment of denture material specimens by antibacterial soap “ClearaSept” and a reliable significant decrease in microbial and yeast adhesion after application of Protefix active cleaner solution, which demonstrates a more significant antimicrobial effect in comparison to “ClearaSept” against Staphylococcus aureus, Escherichia coli, and Candida albicans.
Hydroxychloroquine and SARS-CoV-2 (COVID-19): An Old Problem and New Considerations in Ophthalmology
Authors: Kourkoutas Dimitrios , Triantafyllopoulos George , Karamaounas Aristotelis , Karamaounas Nikolaos
Published: January 2021

The antimalarial hydroxychloroquine (HCQ) has been suggested as a potential drug for treatment and prevention against severe acute respiratory syndrome–coronavirus 2 (SARS–CoV-2). Currently, there is insufficient scientific evidence available on HCQ retinal toxicity associated with the current treatment regimen and dosing for COVID-19 patients. In the sight of the current public health crisis, our recommendations aim to reduce the probability of unfavorable HCQ treatment outcomes and emphasize the importance of monitoring and early detection for HCQ retinopathy by simple means and the need for correlating clinical observations with multimodal imaging. We, therefore, recommend the use of Threshold Amsler grid (TAG) as a screening tool for high risk COVID-19 patients as well as treated patients with visual symptoms. Clinical decisions should be made on an individual basis, taking into consideration any pre-existing liver and kidney disease as well as macular pathology.