bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction Models for Agonists and Antagonists of Molecular Initiation Events for Toxicity Pathways Using an Improved Deep-Learning-Based Quantitative Structure–Activity Relationship System
Authors: Matsuzaka Yasunari , Totoki Shin , Handa Kentaro , Shiota Tetsuyoshi , Kurosaki Kota , Uesawa Yoshihiro
Published: October 2021

In silico approaches have been studied intensively to assess the toxicological risk of various chemical compounds as alternatives to traditional in vivo animal tests. Among these approaches, quantitative structure–activity relationship (QSAR) analysis has the advantages that it is able to construct models to predict the biological properties of chemicals based on structural information. Previously, we reported a deep learning (DL) algorithm-based QSAR approach called DeepSnap-DL for high-performance prediction modeling of the agonist and antagonist activity of key molecules in molecular initiating events in toxicological pathways using optimized hyperparameters. In the present study, to achieve high throughput in the DeepSnap-DL system–which consists of the preparation of three-dimensional molecular structures of chemical compounds, the generation of snapshot images from the three-dimensional chemical structures, DL, and statistical calculations—we propose an improved DeepSnap-DL approach. Using this improved system, we constructed 59 prediction models for the agonist and antagonist activity of key molecules in the Tox21 10K library. The results indicate that modeling of the agonist and antagonist activity with high prediction performance and high throughput can be achieved by optimizing suitable parameters in the improved DeepSnap-DL system.
Sparsity-Based Recovery of Three-Dimensional Photoacoustic Images from Compressed Single-Shot Optical Detection
Authors: Green Dylan , Gelb Anne , Luke Geoffrey P.
Published: October 2021

Photoacoustic (PA) imaging combines optical excitation with ultrasonic detection to achieve high-resolution imaging of biological samples. A high-energy pulsed laser is often used for imaging at multi-centimeter depths in tissue. These lasers typically have a low pulse repetition rate, so to acquire images in real-time, only one pulse of the laser can be used per image. This single pulse necessitates the use of many individual detectors and receive electronics to adequately record the resulting acoustic waves and form an image. Such requirements make many PA imaging systems both costly and complex. This investigation proposes and models a method of volumetric PA imaging using a state-of-the-art compressed sensing approach to achieve real-time acquisition of the initial pressure distribution (IPD) at a reduced level of cost and complexity. In particular, a single exposure of an optical image sensor is used to capture an entire Fabry–Pérot interferometric acoustic sensor. Time resolved encoding as achieved through spatial sweeping with a galvanometer. This optical system further makes use of a random binary mask to set a predetermined subset of pixels to zero, thus enabling recovery of the time-resolved signals. The Two-Step Iterative Shrinking and Thresholding algorithm is used to reconstruct the IPD, harnessing the sparsity naturally occurring in the IPD as well as the additional structure provided by the binary mask. We conduct experiments on simulated data and analyze the performance of our new approach.
Combined Mass Spectrometry and Histopathology Imaging for Perioperative Tissue Assessment in Cancer Surgery
Authors: Connolly Laura , Jamzad Amoon , Kaufmann Martin , Farquharson Catriona E. , Ren Kevin , Rudan John F. , Fichtinger Gabor , Mousavi Parvin
Published: October 2021

Mass spectrometry is an effective imaging tool for evaluating biological tissue to detect cancer. With the assistance of deep learning, this technology can be used as a perioperative tissue assessment tool that will facilitate informed surgical decisions. To achieve such a system requires the development of a database of mass spectrometry signals and their corresponding pathology labels. Assigning correct labels, in turn, necessitates precise spatial registration of histopathology and mass spectrometry data. This is a challenging task due to the domain differences and noisy nature of images. In this study, we create a registration framework for mass spectrometry and pathology images as a contribution to the development of perioperative tissue assessment. In doing so, we explore two opportunities in deep learning for medical image registration, namely, unsupervised, multi-modal deformable image registration and evaluation of the registration. We test this system on prostate needle biopsy cores that were imaged with desorption electrospray ionization mass spectrometry (DESI) and show that we can successfully register DESI and histology images to achieve accurate alignment and, consequently, labelling for future training. This automation is expected to improve the efficiency and development of a deep learning architecture that will benefit the use of mass spectrometry imaging for cancer diagnosis.
Hybrid Scheduling for Multi-Equipment at U-Shape Trafficked Automated Terminal Based on Chaos Particle Swarm Optimization
Authors: Li Junjun , Yang Jingyu , Xu Bowei , Yang Yongsheng , Wen Furong , Song Haitao
Published: October 2021

Aimed to improve the efficiency of port operations, Shanghai Zhenhua Heavy Industries Co., Ltd. (ZPMC) proposed a new U-shape trafficked automated terminal. The new U-shape trafficked automated terminal brings a new hybrid scheduling problem. A hybrid scheduling model for yard crane (YC), AGV and ET in the U-shape trafficked automated terminal yard is established to solve the problem. The AGV and ET yard lanes are assumed to be one-way lane. Take the YC, AGV and ET scheduling results (the container transportation sequences) as variables and the minimization of the maximum completion time as the objective function. A scheduling model architecture with hierarchical abstraction of scheduling objects is proposed to refine the problem. The total completion time is solved based on a static and dynamic mixed scheduling strategy. A chaotic particle swarm optimization algorithm with speed control (CCPSO) is proposed, which include a chaotic particle strategy, a particle iterative speed control strategy, and a particle mapping space for hybrid scheduling. The presented model and algorithm were applied to experiments with different numbers of containers and AGVs. The parameters of simulation part refer to Qinzhou Port. The simulation results show that CCPSO can obtain a near-optimal solution in a shorter time and find a better solution when the solution time is sufficient, comparing with the traditional particle swarm optimization algorithm, the adaptive particle swarm optimization algorithm and the random position particle swarm optimization algorithm.
Oceanographic Drivers of Cuvier’s (Ziphius cavirostris) and Sowerby’s (Mesoplodon bidens) Beaked Whales Acoustic Occurrence along the Irish Shelf Edge
Authors: Barile Cynthia , Berrow Simon , O’Brien Joanne
Published: October 2021

Cuvier’s and Sowerby’s beaked whales occur year-round in western Irish waters, yet remain some of the most poorly understood cetaceans in the area. Considering the importance of the area for anthropogenic activities and the sensitivity of beaked whales to noise, understanding their ecology is essential to minimise potential overlaps. To this end, fixed bottom-mounted autonomous acoustic recorders were deployed at 10 stations over four recording periods spanning from May 2015 to November 2016. Acoustic data were collected over 1934 cumulative days, for a total of 7942 h of recordings. To model the probability of presence of Cuvier’s and Sowerby’s beaked whales in the area as a function of oceanographic predictors, we used Generalised Additive Models, fitted with Generalised Estimating Equations to deal with temporal autocorrelation. To reflect prey availability, oceanographic variables acting as proxies of primary productivity and prey aggregation processes such as upwelling events and thermal fronts were selected. Our results demonstrated that oceanographic variables significantly contributed to the occurrence of Cuvier’s and Sowerby’s beaked whales (p-values between <0.001 and <0.05). The species showed similar preferences, with the exception of sdSST. The inclusion of a parameter accounting for the recorders location confirmed the existence of a latitudinal partitioning for those species in the area. This study provides a point of comparison for future research and represents an important step towards a better understanding of those elusive species.
Three-Dimensional Airway Spheroids and Organoids for Cystic Fibrosis Research
Authors: Laselva Onofrio , Conese Massimo
Published: October 2021

Cystic fibrosis (CF) is an autosomal recessive multi-organ disease caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene, with morbidity and mortality primacy related to the lung disease. The CFTR protein, a chloride/bicarbonate channel, is expressed at the apical side of airway epithelial cells and is mainly involved in appropriate ion and fluid transport across the epithelium. Although many animal and cellular models have been developed to study the pathophysiological consequences of the lack/dysfunction of CFTR, only the three-dimensional (3D) structures termed “spheroids” and “organoids” can enable the reconstruction of airway mucosa to model organ development, disease pathophysiology, and drug screening. Airway spheroids and organoids can be derived from different sources, including adult lungs and induced pluripotent stem cells (iPSCs), each with its advantages and limits. Here, we review the major features of airway spheroids and organoids, anticipating that their potential in the CF field has not been fully shown. Further work is mandatory to understand whether they can accomplish better outcomes than other culture conditions of airway epithelial cells for CF personalized therapies and tissue engineering aims.
New Drugs Bringing New Challenges to AML: A Brief Review
Authors: Yeoh Zhi Han , Bajel Ashish , Wei Andrew H.
Published: October 2021

The better understanding of the genomic landscape in acute myeloid leukaemia (AML) has progressively paved the way for precision medicine in AML. There is a growing number of drugs with novel mechanisms of action and unique side-effect profiles. This review examines the impact of evolving novel therapies on survival in AML and the challenges that ensue.
Gender Differences in Intra-Household Financial Decision-Making: An Application of Coarsened Exact Matching
Authors: Booysen Frederik , Guvuriro Sevias
Published: October 2021

Most studies that explore collective models of intra-household decision-making use economic outcomes such as human capital, earnings, assets, and relative income shares as proxies of the relative distribution of bargaining power. These studies, however, fail to incorporate important measures of control over and management of the economic resources within households. In the current study, a direct measure of financial decision-making power within the household is used to directly assess the distribution of bargaining power. Coarsened exact matching, an identification strategy not yet applied in studies of this nature, is applied to couple-level observational data from South Africa’s longitudinal National Income Dynamics Study. The influence of gender differences in intra-household decision-making on resource allocations to per capita household expenditure is assessed. In the case of greater financial decision-making power in couples being assigned to wives rather than husbands, per capita household expenditure on education increases significantly. The empowerment of women with financial decision-making power therefore holds the promise of realizing the benefits of investments in human capital.
Supplier Encroachment in the Supply Chain in the E-Commerce Age: A Systematic Literature Review
Authors: Li Huijie , Li Zhiguo
Published: October 2021

The evolution of e-commerce drives suppliers to develop online direct selling channels to encroach on the retail market, in addition to the traditional distribution channels through the retailer. A systematic literature review (SLR) approach is adopted in this paper to review the existing studies using theoretical models to capture supplier encroachment behavior, as well as the related industry practice phenomena and strategic factors in the supply chain. We present the major research streams according to the selected encroachment literature from two aspects: channel conflict and coordination as well as information structures. We also generalize the significant practical strategies and strategic factors that have been investigated, combined with supplier encroachment, such as investment and spillover effects, the retailer’s store brand introduction, strategic inventory, and contract mechanism designs. More importantly, we summarize the classical theoretical models which include the basic models, the signaling game model, and the Hotelling model, and these have been widely used by scholars to capture the supplier’s encroachment behavior. Finally, we provide several suggestions which may be valuable for researchers to identify future potential research directions.
THE PROBLEM OF ACADEMIC GENDER MOBBING IN TURKISH UNIVERSITIES
Authors: Ince-Yenilmez Meltem
Published: October 2021

The issue of academic mobbing is growing at an alarming rate in Turkish universities. This is a negative practice whereby outspoken and ethical scholars are attacked. These scholars are always kicking against bad practices in society. They possess knowledge that most people consider intimidating. These actions are usually initiated by their lesser administrators and colleagues. Based on this, it is crucial to know how this problem starts and deteriorates among colleagues. This research study will be aiming to determine mobbing behavior prevalence as exposed by superiors, the dean and heads of departments. Various subtopics will be analyzed and discussed in this paper like faculty outcomes, ethics, and envy twinge. These are all related to rectors, university presidents, provosts, department chairs, deans, policymakers, academic leaders, researchers, academicians, and many others.
A EDUCAÇÃO MORAL/CIDADÃ NA PERSPECTIVA DA PREVENÇÃO DA CRIMINALIDADE: PROJETO ÂNCORA
Authors: Barbosa Araújo Ráylla , Medina Patrícia
Published: October 2021

O presente estudo possui como tema, escolas inovadoras e a formação moral para prevenção da criminalidade; objetivou compreender o Projeto Âncora, registrando suas peculiaridades, especialmente as relacionadas aos aspectos metodológicos da educação moral, comparando-os às teorias de prevenção da criminalidade. Utilizou-se da pesquisa revisão para obtenção de informações em publicações científicas relacionadas às diversas teorias da criminalidade, nas metodologias de educação moral e nos aspectos metodológicos inovadores encontrados no Projeto Âncora. Concluiu-se que os procedimentos educacionais deste Projeto desenvolvem nos educandos o senso de responsabilidade sobre o andamento das questões sociais e que a práticas pedagógicas proporcionam a internalização das morais sociais, fazendo com que os educandos sejam menos propensos a práticas de atos que transgridem as leis e normas traçadas pelo estado.
A SOLIDARIEDADE NO CONSTITUCIONALISMO NORTE-AMERICANO
Authors: Cesar José Matos Rebêlo Felipe
Published: October 2021

A solidariedade se revela uma perspectiva fundamental no âmbito do constitucionalismo. O modelo norte-americano pode ser visualizado com adjetivos específicos, que lhe fornecem um tom diferenciado. O institucionalismo histórico e a teoria democrática dualista, desenvolvidos por Stephen Griffin e Bruce Ackerman respectivamente, podem fornecer uma caracterização peculiar de um constitucionalismo em que o Poder Judiciário encontra abrangência, mas em que outros feixes de atuação não podem ser desconsiderados no processo de aplicação e interpretação da Constituição de 1787. Nesse sentido, as pressões populares e atuação conjunta do Legislativo e do Executivo merecem apreciação, como forma de estabelecimento dos direitos inerentes, mormente aqueles ligados à solidariedade e implementação de políticas públicas em conjugação aos direitos sociais.
A SANÇÃO POLÍTICA COMO FORMA DE COMBATER A CORRUPÇÃO NO DIREITO TRIBUTÁRIO
Authors: Gabriela Borges Costa Nina , De Sousa Trigueiro Charles
Published: October 2021

O presente artigo pretende estudar a validade acerca da aplicação das Sanções Políticas, vistas como restrições ou proibições impostas ao contribuinte, a fim de compeli-lo ao pagamento do tributo devido. Tais sanções foram consideradas inconstitucionais pelo Supremo Tribunal Federal; todavia, a citada Corte Suprema considerou válida a restrição do estabelecimento em um caso específico, ao verificar o histórico de inadimplência por parte de determinada empresa. A partir de então, surge a presunção de que o Supremo Tribunal Federal estaria alterando a sua histórica e consolidada decisão. Desse modo, a fim de responder a tal questionamento, foram apresentados, neste artigo, vários julgados da Suprema Corte no tocante ao tema exposto, restando comprovado que o entendimento quanto à inconstitucionalidade da aplicação das sanções políticas não mudou ao permitir a interdição do estabelecimento, mas conferiu uma interpretação específica ao caso concreto.
A DELAÇÃO PREMIADA COMO NOVA TECNOLOGIA DO PODER PUNITIVO NO ENFRENTAMENTO À CRIMINALIDADE ORGANIZADA
Authors: Macedo de Miranda Bartira , Faipher Morena V. da Silva Dornelas Júlia
Published: October 2021

O presente artigo discute como a Delação Premiada, inserida no contexto de expansão dos espaços de consenso no Processo Penal, apresenta-se como uma nova tecnologia do poder punitivo a pretexto de enfrentar a criminalidade organizada. O ponto de partida da abordagem é a concentração de discursos punitivos no Brasil, bem como a colonização da Política Criminal pela racionalidade neoliberal. Descreve-se como a expansão do Direito Penal e o eficientismo foram determinantes para a importação de mecanismos negociais, dentre os quais a Delação Premiada, no Brasil. Observa-se como a espetacularização do processo penal, combinada com o uso exacerbado da Delação Premiada, pode catalisar a mitigação do Processo Penal Democrático.
Prediction of dendrometric variables by optical data in Pinus taeda L. in the south of Brazil
Authors: Pertille Carla Talita , Nicoletti Marcos Felipe , Topanotti Larissa Regina , Schorr Luís Paulo Baldiserra
Published: October 2021

The objective of this work was to estimate the basal area and volume of a Pinus taeda L. settlement located in Santa Catarina, correlating data from an orbital image of the Landsat-8 / OLI sensor and forest inventory. In this sense, a forest research was carried out, with a random sampling process using the fixed area method. 20 circular parcels of 400 m² were allocated. An orbital image of the Landsat-8 / OLI sensor was used and 10 average vegetation indices per plot were calculated. These were correlated as variables of volume and basal area per plot, decorative by the forest inventory. The index with the best correlation for the volume was GNDVI with 0.47 and for a basal area, the MVI with 0.51. The adjustment of the regression models showed adjusted R² indices of 0.5639 and Syx of 13.31% for volume, and 0.5213 and 11.93% for the basal area. It was possible to estimate the volume and basal area of the stands through the spectral data, however, it is recommended that this same technique be tested in other species of the genus Pinus spp. and with high spatial resolution media.
Autumn migration of Jack Snipe Lymnocryptes minimus in southern Sweden: results from ten years of crepuscular ringing
Authors: Bergner Adam , Elderud Christer , Person Kent , Gezelius Lars
Published: October 2021

The autumn migration of Jack Snipe Lymnocryptes minimus was studied using mist-netting at night along a muddy shoreline at Lake Tåkern in southern central Sweden. During ten consecutive autumn seasons ranging from mid-September to mid-November a total of 107 birds were captured, particularly within the first two hours after dusk. The peak of migration occurred in the first ten days of October with the juvenile birds on average passing a few days earlier than the adult birds. We present information on movements and ringing recoveries and review the challenges of ageing the species. We propose that crepuscular mist-netting near wetlands offering important staging grounds may be a suitable method to monitor the migratory movements, and possibly the population dynamics, of this little-studied species.
Synopsis of the Genus Pentacalia (Compositae, Senecioneae) in Bolivia
Authors: Calvo Joel
Published: October 2021

The Neotropical genus Pentacalia Cass. (Compositae, Senecioneae) is distributed from southern Mexico to northwestern Argentina, plus two disjunct species that thrive in Brazil. Most species diversity occurs in the montane forests of Colombia, Ecuador, and Peru. It comprises scandent woody plants characterized by displaying alternate leaves (opposite in three species), involucres with supplementary bracts, usually yellow ray florets (when present), sagittate to caudate anther bases, and truncate to obtuse style branches with a crown of sweeping trichomes (sometimes with a tuft of longer trichomes, but not strictly penicillate). The Bolivian species were revised for the first time by Cabrera (1985), who treated the group under Senecio L. sect. Streptothamni Greenm. Because of the subsequent addition of new species and the need of taxonomic arrangements, an updated synopsis of the genus recognizing 18 species is presented. The names P. brittoniana (Hieron.) Cuatrec. and P. miguelii (Cuatrec.) Cuatrec. are synonymized with P. psidiifolia (Rusby) Cuatrec., as well as P. inquisiviensis H. Rob. & Cuatrec. with P. cardenasii (Cuatrec.) Cuatrec. and P. sailapatensis (Cuatrec.) Cuatrec. with P. urubambensis (Cabrera) Cuatrec. Seven names are lectotypified and an epitype is designated for the name P. zongoensis (Cabrera) J. Calvo. The new species P. viburnifolia J. Calvo & A. Fuentes is described. Revised nomenclature, succinct descriptions, taxonomic discussions, lists of specimens examined, and distribution maps are provided for all accepted species, in addition to an identification key. Pictures of living plants are also presented for eight species.
Time Well Spent is not the Time Wasted: A Study from the Pandemic
Authors: Darling Selvi V , Kalarani D
Published: October 2021

The word “quarantine” restricts the movement of people and goods intended to prevent the spread of disease or pests. It is often used in connection to disease and illness, preventing the movement of those who may have been exposed to a communicable disease but do not have a confirmed medical diagnosis. It is distinct from medical isolation, in which those confirmed to be infected with a communicable disease are isolated from the healthy population. Quarantine considerations are often one aspect of control. A distinctive attribute or characteristic possessed by someone or something. “he shows strong leadership qualities.” A sample of one hundred and thirty-eight persons was taken for study. The various dimensions of Quality Time on Quarantine Days Were evaluated with the help of an Interview Schedule. The data collected were analyzed with the help of percentage analysis, Factor Analysis, and KMO. The researcher used IBM-SPSS version 20 software for the analysis and interpretation of data. In a recent study, it was found that time was spent on helping with family members regularly, online streaming, involvement in spiritual activities, playing online games and webinars, suffering social media, outdoor games, and watching television for spiritual programs.
Nature and Magnitude of COVID-19 First Wave in Tamil Nadu, India
Authors: Devi Priya P
Published: October 2021

The first case of COVID-19 Tamil Nadu was confirmed on 7th March 2020 in Chennai after aninternational travel from Muscat. The specific objectives of the study were to analyze the trends inCOVID 19 in Tamil Nadu from March 2020 to January 2021 and examine the pattern of it sex-wiseamong the age groups. The risk of COVID-19 was accessed with the computation of positive testrate, prevalence rate and fatality rate. The prevalence rates were highest in August, with a slightdownfall in September 2020 in the state. The positivity test rate was high in June and July. Then itstarted declining and has been one percent in January. About 83 percent of the occurrence of thevirus was among the middle age group, 13 percent among the elderly and four percent among thechildren. Intensifying immunity boosters, personal and public hygiene, vaccination on a large scaleprobably would contain the second wave and prohibit the third wave for the survival of humanity
ЦЕРВІКАЛЬНІ УРАЖЕННЯ ТВЕРДИХ ТКАНИН ЗУБІВ У ХВОРИХ НА ГЕНЕРАЛІЗОВАНИЙ ПАРОДОНТИТ ВІДПОВІДНО ДО ГЕНДЕРНОЇ ПРИНАЛЕЖНОСТІ ТА ВІКУ
Authors: Мазур І.П. , Супрунович І.М. , Новошицький В.Є.
Published: October 2021

Цервікальні ураження твердих тканин зубів часто зустрічаються під час практичної діяльності лікарів-стоматологів.Метою даного дослідження було вивчити пошире-ність цервікальних уражень твердих тканин зубів у хворих на генералізований пародонтит, проаналізу-вати їх розподіл відповідно до гендерної приналежно-сті та віку, функціональної приналежності зубів вер-хньої та нижньої щелеп.Матеріали та методи дослідження. У дослідженні взяло участь 133 пацієнтів з генералізованим пародо-нтитом, яким було проведено комплексне обстежен-ня на наявність цервікальних уражень твердих тка-нин зубів: абфракцій, ерозій, карієсу кореня та комбі-нованих уражень. Кожний учасник заповнював анке-ту опитувальник щодо впливу потенційних етіологіч-них факторів. Залежно від гендерної приналежності пацієнти були розподілені на групи жінок та чолові-ків, залежно від віку – на групи двадцятирічних, три-дцятирічних, сорокарічних та п’ятдесятирічних.Результати дослідження показали, що поширеність цервікальних уражень твердих тканин зубів у паціє-нтів з генералізованим пародонтитом становила 67,67 %. Загальна поширеність абфракцій склала 59,40 %, комбінованих уражень – 14,29 %, ерозій – 1,50 %, карієсу кореня – 12,78 %. Поєднані ураження зустрічались у 20,30 % обстежуваних. З віком поши-реність цервікальних уражень збільшується: у два-дцятирічних абфракції були присутні у 10,53 % об-стежуваних, у тридцятирічних та сорокарічних – у 59,52 %, у п’ятдесятирічних – у 90,00 %. Порівняль-ний аналіз поширеності цервікальних уражень в за-лежності від статі продемонстрував вірогідно вищі показники ураження карієсом у жінок (20,00 %) порі-вняно з чоловіками (4,76 %) (p=0,009). Не виявлено достовірної різниці поширеності абфракцій та ерозій між особами чоловічої та жіночої статі. Найвища поширеність абфракцій та комбінованих уражень була зафіксована на премолярах нижньої щелепи, ка-рієсу кореня – на бічних різцях верхньої щелепи та пе-рших молярах нижньої щелепи, ерозій – на іклах, молярах та премолярах верхньої і нижньої щелеп.Висновок. Висока поширеність цервікальних уражень твердих тканин зубів у хворих на генералізований па-родонтит зумовлює необхідність впровадження протоколу профілактики карієсу кореня та некаріоз-них уражень твердих тканин зубів, який буде не-від’ємним компонентом підтримувального пародон-тологічного лікування.
КЛІНІКО-АНАТОМІЧНІ ОСОБЛИВОСТІ ПЕРЕЛОМІВ ВЕРХНЬОЇ ЩЕЛЕПИ У ПАЦІЄНТІВ ІЗ РІЗНИМ ТИПОМ ЇЇ ПНЕВМАТИЗАЦІЇ
Authors: Шуминський Є. В. , Копчак А. В.
Published: October 2021

Індивідуальна анатомія кісток середньої зони облич-чя (КСЗО) позначається на особливостях їх руйну-вання та ускладнює процес лікування та реабілітації пацієнтів із травматичними переломами.Мета. Вивчення взаємозв’язків між клініко-рентгенологічними характеристиками переломів вер-хньої щелепи (ВЩ) та особливостями її будови, зок-рема ступенем пневматизації.Матеріали і методи. Проаналізовано та порівняно значення кількості щілин переломів, кількості улам-ків, частоту утворення дефектів на ділянках контр-форсів, показник Facial Injury Severity Scale у пацієн-тів із різним значенням індексу пневматизації (ІП).Результати. Пневматичний тип будови КСЗО хара-ктеризується збільшенням ступеня фрагментації та утворенням дефектів контрфорсів ВЩ у порівнянні з нормальним типом будови (66 % та 58 % відповідно, р>0,999).Висновки. Характеристики переломів ВЩ залежать від особливостей її архітектоніки, а саме від ІП, що необхідно враховувати при плануванні лікувальних заходів.
Efecto de tratamientos hormonales sobre la eficiencia reproductiva, mortalidad embrionaria y fetal, en ovejas merino de la Patagonia norte
Authors:   , Fernández Jimena
Published: October 2021

Se estudió el efecto de la administración de hCG o GnRH a los 4 días posinseminación en ovejas Merino sobre: - la inducción de cuerpos lúteos accesorios (CL acc), la concentración de progesterona [P4] (Ensayo I), - las características funcionales de los CL posovulatorio y acc (Ensayo II), y - la eficiencia reproductiva (porcentaje de preñez, pérdidas gestacionales, tamaño del embrión, prolificidad y peso al nacimiento de los corderos; Ensayo III). Las ovejas se distribuyeron al azar en tres grupos exprimentales: Grupo GnRH (4 µg), Grupo hCG (300 UI), Grupo Control (solución fisiológica). Ensayo I: La administración de hCG o GnRH generó un CL acc (P≤ 0,05) a partir de folículos de 3, 4 o 5 mm presentes al momento del tratamiento. La [P4] sólo aumentó en el Grupo hCG (P≤ 0,05) y no dependió del tamaño del folículo que generó el CL acc (P> 0,05). Ensayo II: El área inmunomarcada para STAR y 3 β HSD (P≤ 0,05) y la expresión de ARNm de STAR, 3 β HSD y P450 (P≤ 0,1), principalmente en el CL acc, fue mayor en el grupo hCG. Ensayo III: No se observó un incremento en la tasa de preñez y el tamaño del embrión (P> 0,05). Se observó una disminución de las pérdidas de preñez en el Grupo hCG (P≤ 0,05) y un incremento tendencial de la prolificidad en el Grupo GnRH (P≤ 0,1). La fertilidad de los carneros y la condición corporal de las ovejas influyeron en el efecto de los tratamientos hormonales sobre el porcentaje de preñez. Se concluye que, la administración de hCG en la fase luteal induce un CL acc con mejor capacidad esteroidogénica incrementando la [P4]. Sin embargo, a pesar de observarse una disminución de las pérdidas gestacionales, no se reflejó un incremento en la preñez.
Pemahaman Hadis Yusuf al-Qardhāwy: Telaah atas Kaidah al-Tamyīz Bayna al-Wasīlah al-Mutaghayyirah wa al-Hadhf al-Thābit
Authors: Zulfikar Eko
Published: October 2021

Abstract: As the second legacy of Islamic teachings after the al-Qur’an, hadith is a set of teachings that provide various guiding solutions to navigate the dynamics of life. It is very reasonable if comprehending the hadith comprehensively is very necessary to find the meaning of a hadith based on the development and demands of the times. This paper discusses the construction of the understanding hadith offered by Yusuf al-Qardhawy in the book Kayfa Nata’amal ma’a al-Sunnah al-Nabawiyyah. From several methods offered by al-Qardawy in the book, the author specifies on one of his rules, namely al-Tamyiz Bayna al-Wasilah al-Mutaghayyirah wa al-Hadhf al-Thabit. By reading it from the perspective of constructivism, purely library research and analysis of intercontextual data, it is found that understanding in addition to al-Qardhawy in using this rule always relates hadith with something current and always up to date, he also tries to apply it to elastic traditions of regional conditions and open to the times.
Amalgamasi Sunni dan Syi’ah di Kampung Arab Bondowoso
Authors: Musdhalifah Musdhalifah
Published: October 2021

Abstract: Marriage aims to achieve the happiness of family members. The phenomenon of inter-sectional marriage between Sunnis and Shiites 60% occurin the Bondowoso Arabian Community. Although between the two sects there are differences in Sunni and Shia teachings which can be said to be very much different. One of them is a matter of perspective from aqidah but they can undergo differences in the family. If in the difference disputes and tensions occur in the family so the marriage is not done. The Indonesian Ulema Council (MUI) Bondowoso has a different opinion from the response of the Central Indonesian Ulama Council (MUI) to the Shiite groups in Bondowoso on the grounds so that the people in Bondowoso are safe and secure. Concerned that the Bondowoso community is in conflict between two groups.
Metode Perhitungan Awal Bulan Kamariah Uzal Syahruna dalam Kitab Tasḥīl al-Mithāl wa al-Aqwāl Li ‘Amal al-Hilāl
Authors: Rosyid Maskur , Lusdianto Karis
Published: October 2021

Abstract: This study aims to determine the method of ḥisāb early in the lunar month in the book Tasḥīl al-Mithāl by Uzal Syahruna and assess its advantages and disadvantages compared to the same process in other books. It is undeniable that the dichotomization between the existence of classical ḥisāb books and contemporary ḥisāb books with the beginning to fade in people's belief in the results occurred in Falak Science. Through literature study and interviews, this paper finds that the method of determining the beginning of the lunar month in the book falls into the ḥisāb ḥaqīqī bi taḥqīq category. The theory and calculation system are based on modern astronomical formulas (spherical trigonometry), using calculators and computational programs. The advantage of this book is that it establishes its procedures on current astronomical formulas, the output of ḥisāb is not much different from other ḥaqīqī bi taḥqīq books. Simultaneously, the weakness is that it still uses unlimited astronomical data as a basis. Some have not been corrected, especially for determining irtifā 'al-hilāl and hilāl mar'i corrections.
Perdebatan dalam Al-Qur’an: Analisis Tematik Ayat-Ayat Mujadalah yang Turun di Makkah (Makkiyyah)
Authors: Nabrisah Zulfan
Published: October 2021

Abstract: This study discusses the dispute between the infidels and prophets mentioned in the Qur’an (mujadalah verses). Therefore, the study used refers to the maudu’i method (thematic method). The study concludes that the topic of the mujadalah verses consists of (1) the dispute is a natural human tendency (fiṭrah); (2) the prophets and the truth of the divine revelation were always disputed by the infidel (kāfir); (3) Allah commands the believers (mu’mīn) to debate them wisely (ḥasanah), even though the infidels use the despicable manner (baṭil), and; (4) Allah will difinitely punishes anyone who denies the truth of His revelation.
Kajian Analisis terhadap Kitab Hadith al-Durrah al-Saniyyah Karangan Haji Ismail Bin Omar al-Patani
Authors: Sempo Muhammad Widus , Salaeh Abdulloh , Halim Amran Abdul , Syed Hasaan Syed Najihuddin , Al-Fathoni Idi Hamdi
Published: October 2021

Abstract: Prophet Muhammad (PBUH) is one of the Ulul Azmi and being appointed as the leader for the humankind through his speeches, works and other things related to his Sunnah. The main objective of this study is to introduce the prominent Islamic scholar in Hadith, Baba Ismail Sepanjang and his book ‘Al-Durrah Al-Saniyyah’ and to highlight his exceptional contribution in this field. This study relies on many types of approaches including both qualitative and quantitative method. This study finds that Tuan Guru Haji Ismail bin Omar teaches hadith very clear and gives an excellent contribution in the field of hadith for Muslim society in Patani through his writings and his speech.
Religious Harmony, Godly Nationalism, and the Limits of State-sponsored Interreligious Dialogue Agenda in Indonesia
Authors: Sopyan Imam , Fauzan Pepen Irpan , Fata Ahmad Khoirul
Published: October 2021

Abstract: This paper discus the discourse of religious harmony in Indonesia by looking into the role played by PKUB/FKUB, a state-sponsored body focused on maintaining religious harmony, in the context of interreligious dialogue agenda in Indonesia. By looking into its trajectory and legal standing, this paper hypothesizes that there are some limits within the PKUB/FKUB in addressing the spirit and practice of interreligious dialogue to the Indonesian public due to the preference of religious harmony rather than interreligious dialogue. This paper then wants to explore the preference of religious harmony by employing Godly-Nationalism/Productive Intolerance concept. The data of this paper is collected by library research methodology. Finally, this paper suggests that despite the discourse of religious harmony requires the religious community to engage in the dialogue, there is a different direction and objective to which the dialogue would lead. While the dialogue in the context of religious harmony would be directed to maintaining harmony itself, the interreligious dialogue as suggested by several scholars requires religious people to learn from others to change and grow together.  

Keywords: Interreligious Dialogue, Religious Harmony, PKUB, FKUB, Godly- Nationalism.
Female Bildungsroman in the Narrative of African Women Writers
Authors: GUEYE, Mansour
Published: October 2021

This paper addresses the ‘Bildungsroman’ genre in African postcolonial narratives. It mainly focuses on African women writers’ literary works and, specifically, aims to shed light on how they blend female subjugation with an unknown genre in the narrative of female characterization and autobiographies. The study also evidences that, even though, the term ‘Bildungsroman’ is German in origin, i.e., ‘bildung’, which means apprenticeship, self-cultivation, formation, etc; and the word ‘roman’ which means novel, the concept is fully adapted and adopted in African male and female writers’ literary discourses. Thus the paper seeks to demonstrate that colonization in Africa has had intellectual impacts on modern African literature, as the pioneers of contemporary African literature have used foreign languages to write back, claim cultural retrieval, independence and represent their own experience through their own perspective and narrative in the midst of their protagonists’ psychological and physical transformation.
QUESTIONNAIRE STUDY ON KNOWLEDGE AND AWARENESS OF COVID -19 AMONG GENERAL POPULATION
Authors: J Manju. , Sangeeta Devi Mutum , R Preeti. , Loushambam Preety , S Sivakumar.
Published: October 2021

COVID 19 is a respiratory communicable disease which has created worldwide crisis. The aim of this
study is to assess the knowledge and awareness of this disease among the general population for which
online based circulation of a multiple choice type questionnaire which consisted of 10 questions was used. About 100
participants were included in the study. The data thus received was transferred to excel sheet and assessed as percentages.
Most of them have responded positively and there was deciency for few questions only. The limitation of the study is the sample
size and the participants are those who had the facility of internet connection.
“THE EFFECT OF CYPROTERONE ACETATE AND ETHINYLESTRADIOL COMBINATION ON HYPERANDROGENIC AND OTHER SYMPTOMS IN PCOS”
Authors: Jain Uma , chimrani Jayshree , Krishna Kajal
Published: October 2021

INTRODUCTION- Polycystic ovarian syndrome (PCOS) is a common, heterogeneous disorder affecting
5-15% of women of reproducing age group and characterized by hyperandrogenic skin symptoms,
(acne, Hirsutism and female pattern alopecia,) irregular menstrual bleeding, obesity, dysmenorrhea infertility, and increased
risk of metabolic syndrome and endometrial cancer.
MATERIAL AND METHOD-The present study was conducted in a private gynecological Clinic Shivpuri, (M.P.). After taking
Consent women suffering from PCOS (Fullled the clinical and USG criteria of PCOS(Rotterdam criteria )) along with
androgenic symptoms like acne, hirsutism and androgenetic alopecia with or without other symptoms like menstrual
irregularities and dysmenorrhea were included in the study..
All patients then received a combination of ethenyl Estradiol (0.035mg) + Cyproterone acetate (2mg). The Patients were
followed in the third month, Sixth month, and at about 1 year for improvement in various complaints
RESULT- According to presenting symptoms the most common presenting symptom was acne 72.72%, followed by menstrual
irregularities 68.18%, hirsutism 50%, alopecia 27.27%, and dysmenorrhea in 27.27%.
In acne patients, 37.5% of patients showed improvement after 3 cycles of CPA/EE, 75% showed at 6 months and in 93.75%,
improvement was seen at 12 months. In the case of alopecia (83.33%) patient showed improvement after >6 cycles. Patients
with hirsutism showed no improvement after 3 months of therapy but 54.54% of the patients showed a change in texture after 6
months of therapy and 72.72% after 9-12 months of therapy. Patients with dysmenorrhea reported a decrease in pain after
therapy.
The acceptance of the treatment was very good. In 86.36% of patients, good tolerance of drug was seen and in only 3 patients
adverse effects (headache and nausea) of the drug were there.
All the patients were having good to moderate satisfaction with the therapy.
CONCLUSION- Since androgen excess is the prime defect in polycystic ovarian disease, its reduction is the main therapeutic
target for most women. Our study found that combined hormonal contraceptives containing ethenyl Estradiol (0.035mg) +
Cyproterone acetate (2mg) in a 21/7 regimen had a positive effect in the treatment of acne, hirsutism, menstrual irregularity,
and dysmenorrhea in PCOS patients.
PLEOMORPHIC RHABDOMYOSARCOMA IN THE HEAD AND NECK REGION: A RARE CASE REPORT
Authors: Kanimozhi S. , sri P. Pooja , Karthika P. , Kumar M. Sathish , Mohan A. Mathan
Published: October 2021

Rhabdomyosarcoma (RMS) is a rare, aggressive, malignant mesenchymal tumor of skeletal muscle
cells. The pleomorphic histological variant of RMS occurs in adults beyond 45years of age and represents
the most aggressive subtype with an incidence of approximately 0.44/100,000. The diagnosis of RMS is difcult with the 5year
overall survival rate less than 50%. It presents varied clinical and biological behavior and requires individualized
management. The common region of metastasis includes lymph nodes, lungs and bone marrow. Here we report a case of
pleomorphic rhabdomyosarcoma in 58year old female. The patient reported with a swelling in the neck region and had a history
of surgical treatment for ovarian tumor. Histopathology ndings revealed metastatic undifferentiated carcinoma. The case was
positive for immunohistochemistry markers and their ndings are diagnosed as pleomorphic rhabdomyosarcoma. This is a rare
case of RMS which had metastasized to head and neck and this article emphasizes the importance of IHC in accurate and clear
diagnosis of RMS.
L'AIUTO CHE TI SERVE
Authors: MARTINI LUCA
Published: October 2021

Il profitto e il capitale rappresentano oggi una sfida di lungo periodo alla quale si può partecipare solo mediante un sopporto informatico adeguato alla vision su dimensione contingente e prospettica della struttura organizzativa dell'impresa. Il libro presenta quindi tre categorie di servizi rivolte ad una specifica casistica di vicende in cui ciascun imprenditore si può ritrovare in relazione allo stadio di sviluppo della sua impresa ed una nuova tecnica, quella del Personal Event in cui le persone sono poste al centro del processo organizzativo rivolto all'accumulazione del capitale monetario e intellettuale.
Expert Knowledge Correlated Intrusion Detection System Evaluation Framework for Heterogeneous IoT
Authors: A Nitish , Hanumanthappa J. , S.P Shiva Prakash , Krinkin Kirill
Published: October 2021

The dynamic contexts of heterogeneous Internet of Things (HetIoT) adversely affect the performance of learning-based network intrusion detection systems (NIDS) resulting in increased misclassification rates---necessitating an expert knowledge correlated evaluation framework. The proposed generalizable framework includes intrusion root cause analysis, correlation model, and correlated classification metrics that can be generalized over any NID dataset, corresponding expert knowledge, detection technique, and learning-based algorithm to facilitate context-awareness in reducing false alerts. To achieve this, we perform experimentations on the Bot-IoT dataset---with generalized traffic behaviors from multiple existing NID datasets---employing the Support Vector Machine (SVM) machine learning and Multilayer Perceptron (MLP) shallow neural network classifiers, demonstrating the generalizability, robustness, and improved performance of the propounded framework compared to the existing literature. Furthermore, the proposed framework offers minimal processing overhead on the classifier algorithms.
Expert Knowledge Correlated Evaluation of Intrusion Detection System in Heterogeneous IoT
Authors: A Nitish , J Prof.(Dr).Hanumanthapppa , S.P Shiva Prakash , Krinkin Kirill
Published: October 2021

The dynamic heterogeneous IoT contexts adversely affect the performance of learning-based network intrusion detection and prevention systems resulting in increased misclassification rates—necessitating an expert knowledge correlated evaluation framework. The proposed framework includes intrusion root cause analysis and a correlation model that can be generalized over any network intrusion dataset, corresponding expert knowledge, detection technique, and learning-based algorithm. The experimentations prove the robustness of the propounded

framework on imbalanced datasets.
СТРАТЕГІЧНІ ПРІОРИТЕТИ ПОЛІТИКИ ЗМІЦНЕННЯ КОНКУРЕНТОСПРОМОЖНОСТІ АГРОПРОДОВОЛЬЧОЇ ПРОДУКЦІЇ УКРАЇНИ
Authors: Васильців Т. Г.
Published: October 2021

Обґрунтовано важливість формування та реалізації стратегічних пріоритетів державної по-літики посилення конкурентоспроможності вітчизняної агропродовольчої продукції на внутрішньому та зов-нішніх ринках. Вказано на потенціал вітчизняного агропродовольчого сектора на зовнішніх ринках збуту аг-рарної та продовольчої продукції. Виявлено недоліки системи державної політики програмування розвитку та посилення конкурентних позицій вітчизняного сектора агропродовольчої продукції. Виявлено слабкі місця стратегічного програмування державної політики формування засад конкурентоспроможності вітчизняної агропродовольчої продукції. Визначено напрями та заходи усунення перешкод зміцнення конкурентоспромож-ності агропродовольчої продукції в Україні та її регіонах. Доведено, що пріоритетними напрямами державної політики у цьому руслі потрібно розглядати: удосконалення макроекономічних характеристик середовища виробництва та збуту продукції агропродовольчого комплексу; зміцнення фінансової безпеки суб’єктів – ви-робників агропродовольчої продукції; розвиток експортного потенціалу агропродовольчої продукції; поліпшен-ня інвестиційного середовища в агропромисловому секторі; забезпечення науково-технологічної компоненти розвитку сектора; зміцнення виробничого складника конкурентоспроможності агропродовольчого підкомп-лексу АПК; посилення енергетичної забезпеченості та зростання енергоефективності в підкомплексі; покра-щення екологічної безпеки агропродовольчого сектора. Визначено стратегічні засади політики забезпечення конкурентоспроможності агропродовольчої продукції України, зокрема за такими елементами, як мета стратегії, її нормативно-правова основа та напрями реалізації, засоби забезпечення і засоби контролю реалі-зації стратегії.