bluuebunny/crossref_metadata_2025 huggingface dataset:
Practical procedures for sensor quality assessment
Authors: Alferes J. , Grievson O. , Heffernan C. , Lumley D. , Massiri T. , Menniti A. , Samuelsson O. , Villez K. , Zegers E.
Published: June 2024

Sensors are increasingly deployed for process monitoring and control. These produce on-line measurements at a high frequency, in parallel with low-frequency laboratory measurements. Compared to laboratory practices, sensor data quality assessment and control practices are far less structured at most utilities. This leads to inaccurate sensor data with unknown uncertainty factors.

This chapter shows how to establish standard operating procedures (SOPs) to support sensor data quality assessment and control and subsequent maintenance actions by producing relevant sensor metadata. Furthermore, SOPs are provided for the most commonly used wastewater quality sensors, inspired by utility and academic best practices. This chapter builds on definitions provided in Chapter 3 and provides additional definitions specifically related to sensors maintenance. Chapter 6 complements the methods in this chapter, which are based on reference measurements, with data-analytical techniques.
Conclusions and outlook
Authors: Aguado D. , Alferes J. , Menniti A. , Plana Q. , Ruano M. V. , Samuelsson O. , Villez K. , Zegers E.
Published: June 2024

In this chapter, we provide notes on the state of metadata collection and organization practices and reflect on the achievements of the MetaCO task group. We also include an utility perspective on how to use this report in daily data management practice and a short guide is provided to show how metadata practices can be initiated. The chapter, and the report, is concluded within an outlook, sketching future progress and opportunities on the horizon.
The effect of using jug-type water filters on selected metals concentration in tap water – a case study
Authors: Kwiatkowski Hubert , Kreft Ksawery , Ronda Oskar , Cieślik Bartłomiej Michał
Published: June 2024

In this study, the effect of the filtration process on Na, K, Mg, Ca, Fe and Zn concentration in water, using filters from one of the leading European manufacturers, was investigated. The increase in Na (up to 300%) and K concentration (up to 320%) at the beginning of jug filter usage was reported. A decrease in Ca, Fe and Zn concentration was observed. Standard filters remove 80–90% of Mg from tap water at the beginning of the usage, while magnesium-enriching ones slightly increase its concentration – from around 8 to 12–25 mg/L. Significant changes in the filter's operating characteristics were also observed for other studied elements as they wore out. Using Mg-enriching filters can increase magnesium intake from 4–5 to 6–15% of the recommended daily dose from water consumption. The results were also discussed regarding the amounts of macroelements found in commercially available bottled water. The magnesium concentration in tap water after filtration through magnesium-enriching filters was lower compared to bottled mineral waters. The authors note a scope for the development of water filter production technology, in particular, the need to develop filters that more efficiently enrich water with magnesium and do not increase sodium concentration.
Integration and Optimization of Heterogeneous Energy Resource Accounting Systems in Multi-Storey Buildings: Benefits and Challenges
Authors: Kelas'ev Andrei Aleksandrovich
Published: June 2024

The article discusses the main aspects of integrating and optimizing heterogeneous energy resource accounting systems in multi-storey buildings. It describes benefits such as improved data accuracy and reduced operational costs, as well as challenges related to technical complexity and the need for standardization. Special attention is given to the analysis of methods for integrating various types of measuring instruments and software, which improves energy consumption management and ensures reliable data collection. Examples of successful implementations in various residential complexes are provided, illustrating real-world results and the economic efficiency of such approaches. The main technical and organizational challenges, including compatibility issues, data security problems, and the need to adapt existing systems, are also discussed. Recommendations for further development in this area are proposed, aimed at overcoming existing barriers and enhancing the interaction between different components of the energy resource accounting system.
Main karst and caves of Switzerland
Authors: Jeannin P.-Y.
Published: June 2024

This paper presents an overview of the main karst areas and cave systems in Switzerland. The first part encloses descriptions of the main geological units that hold karst and caves in the country and summarizes a brief history of research and protection of the cave environments. The second part presents three regions enclosing large cave systems. Two regions in the Alps enclose some of the largest limestone caves in Europe: Siebenhengste (Siebenhengste cave system with ~160 km and Bärenschacht with 70 km) and Bödmeren-Silberen (Hölloch cave system with 200 km and Silberen System with 39 km). These systems are also among the deepest with depths ranging between 880 and 1 340 m. The third example is from the Jura Mountains (northern Switzerland).
A brief history of exploration in Lechuguilla Cave in New Mexico, USA
Authors: Lyles J.T. M. , Davis D.G.
Published: June 2024

Lechuguilla Cave, a complex three-dimensional cave with a single known entrance, is located in remote desert terrain in Carlsbad Caverns National Park, in southeastern New Mexico, USA. The Guadalupe Mountains there contain uplifted limestone and dolomite rock in the Permian-age Capitan Reef complex. Hundreds of caves have been found in this region, but Lechuguilla Cave greatly exceeds the size of all others known. It was only a small pit mined for bat guano in the early twentieth century. In the 1970s the Cave Research Foundation performed digs at the bottom, where profuse air movement had been noted in the debris. This work ceased but another team of cavers visited in 1984, hearing and feeling the significant air, and began a digging project approved by the Park. The cavers dug into continuing passage in 1986. It was explored in three major branches, generally trending west/southwest to east/northeast, parallel to the reef face, with north-south connections along deep rift features. Depositional and corrosional events during sulfuric-acid speleogenesis created remarkable speleothems and speleogenesis, and the cave has often been called “the Jewel of the Underground”. The rapidly growing cave passed 80 km of surveyed length by 1990. Within the first ten years of exploration, 28 large-scale expeditions led to the cave reaching 113 km in length. From 1997 to 2013, 109 additional kilometers were mapped with smaller teams of up to 12 cavers per expedition. Exploration and mapping is now done in three to five expeditions per year, and recent work has focused on climbs and smaller leads such as tight crawls and fissures that were previously passed. Significant discoveries continue to be found using these techniques. The cave reaches a depth of 475 m and has been mapped to over 222 km in length. Exploration to the extreme ends is efficiently done with multi-day expeditions, using established camps in each branch. Cavers from the United States and dozens of other countries have been involved in this mapping project. The cave now has more than 35,000 survey stations, and the complexity of the maze of passages creates significant challenges for cartographers. Based on ever-present airflow and porosity of the bedrock, it is expected that this cave will continue to surprise and delight explorers and speleo-scientists in the future.
Vernodalin Alleviates Cardiotoxicity and Inflammation in Isoproterenol-Mediated Myocardial Infarction through NF-κB/AMPK Signaling Pathways in Rats
Authors: Tao Tao , Sun Xiaona , Zhang Tuowei , Vijayalakshmi Annamalai , Niu Fangqiao
Published: June 2024

Background:

Myocardial infarction (MI) is the foremost cause of mortality in cardiovascular
diseases. MI ultimately exacerbates cardiotoxicity due to the release of toxicity biomarkers
and inflammatory infiltration.

Aim:

Vernodalin (VN) is a renowned cytotoxic sesquiterpene lactone that possesses antioxidant,
anticancer, and anti-inflammatory properties. The cardioprotective mechanism of VN remains
concealed. Hence, we explored the cardioprotective efficacy of VN on isoproterenol (ISO)-
mediated MI and analyzed its underlying mechanism.

Methods:

Wistar albino rats were injected ISO (85 mg/kg bw) subcutaneously to induce MI to
evaluate the cardioprotective potential of VN (10 mg/kg bw) by assessing heart weight/ body
weight index, hemodynamic, toxicity enzymes, histopathology, inflammatory mediators, and
signaling pathway. ISO enhanced heart weight/body weight index, cardiotoxicity enzymes, biomarkers,
inflammation, and histopathological changes while reducing hemodynamic parameters
and VEGF-B, AMPK, and eNOS signaling pathways.

Results:

Treatment with VN could significantly (p<0.05) mitigate the heart weight/body weight
index, cardiotoxicity enzymes, biomarkers, inflammatory cytokines, and histopathological
changes while enhancing hemodynamic parameters and VEGF-B, AMPK, and eNOS signaling
pathways. Collectively, our findings revealed that the VN ameliorated defensive action against
MI and averted myocardial injury by reducing the NF-κB-mediated inflammatory pathways in
rats.

Conclusion:

These findings established that VN expressively preserves the myocardium and
employs anti-inflammatory actions by regulating NF-κB, VEGF-B, AMPK, and eNOS signaling
pathways.
Artificial Intelligence in Eye Movements Analysis for Alzheimer’s Disease Early Diagnosis
Authors: Farabi Maleki Shadi , Yousefi Milad , Sobhi Navid , Jafarizadeh Ali , Alizadehsani Roohallah , Gorriz-Saez Juan Manuel
Published: June 2024

:

As the world's population ages, Alzheimer's disease is currently the seventh most common
cause of death globally; the burden is anticipated to increase, especially among middle-class
and elderly persons. Artificial intelligence-based algorithms that work well in hospital environments
can be used to identify Alzheimer's disease.
A number of databases were searched for English-language articles published up until March 1,
2024, that examined the relationships between artificial intelligence techniques, eye movements,
and Alzheimer's disease.
A novel non-invasive method called eye movement analysis may be able to reflect cognitive processes
and identify anomalies in Alzheimer's disease. Artificial intelligence, particularly deep
learning, and machine learning, is required to enhance Alzheimer's disease detection using eye
movement data. One sort of deep learning technique that shows promise is convolutional neural
networks, which need further data for precise classification. Nonetheless, machine learning models
showed a high degree of accuracy in this context. Artificial intelligence-driven eye movement
analysis holds promise for enhancing clinical evaluations, enabling tailored treatment, and fostering
the development of early and precise Alzheimer's disease diagnosis.
A combination of artificial intelligence-based systems and eye movement analysis can provide a
window for early and non-invasive diagnosis of Alzheimer's disease. Despite ongoing difficulties
with early Alzheimer's disease detection, this presents a novel strategy that may have consequences
for clinical evaluations and customized medication to improve early and accurate diagnosis.
Alternatives to β-Lactams as Agents for the Management of Dentoalveolar Abscess
Authors: Kaushik Aditi , Rana Nidhika , Ashawat Mahendra Singh , Ankalgi Amardeep , Sharma Ankit
Published: June 2024

:

Dentoalveolar abscess are localized infections within the tooth or the surrounding alveolar bone, often resulting from untreated dental caries or dental trauma causing alveolar bone resorption or even loss. Serious consequences arising from the spread of a dental abscess can often lead to significant morbidity and mortality. The acute dentoalveolar abscess is a polymicro-bial infection comprising strict anaerobes, such as anaerobic cocci i.e., Prevotella fusobacterium species, and facultative anaerobes i.e., Streptococci viridians and Streptococcus anginosus. Moreover, inappropriately managed dental infections can progress to severe submandibular space infections with associated serious complications, such as sepsis and airway obstruction. An audit of the Hull Royal Infirmary between 1999 and 2004 showed an increase in the number of patients presenting to oral and maxillofacial surgery services with dental sepsis. Thus, the scientific com-munity is forced to focus on treatment strategies for the management of dentoalveolar abscess (DAA) and other related dental problems. The current treatment includes antibiotic therapy, including β-lactams and non-β- lactams drugs, but it leads to the development of resistant micro-organisms due to improper and wide usage. Furthermore, the currently used β-lactam therapeutics is non-specific and easily hydrolyzed by the β-lactamase enzymes. Thus, the research focused on the non-β-lactams that can be the potential pharmacophore and helpful in the management of DAA, as the appropriate use and choice of antibiotics in dentistry plays an important role in antibiotic stewardship. The newer target for the choice is NLRP inflammasome, which is the major chemical mediator involved in dental problems. This review focused on pathogenesis and current therapeutics for the treatment of dentoalveolar abscesses.
Gallocin-derived Engineered Peptides Targeting EGFR and VEGFR in
Colorectal Cancer: A Bioinformatic Approach
Authors: Kavyani Batoul , Saffari Fereshteh , Afgar Ali , Kavyani Sajjad , Rezaie Masoud , Sharifi Fatemeh , Ahmadrajabi Roya
Published: June 2024

Background:

Colorectal cancer (CRC) treatment using time-saving and cost-effective
targeted therapies with high selectivity and low toxicity drugs, is a great challenge. In primary investigations
on Gallocin, as the most proposed factor in CRC pathogenesis caused by Streptococcus
gallolyticus, it was surprisingly found that this bacteriocin has four α-helix structures and
some anti-cancer sequences.

Objective:

The aim of this study was to determine the ability of Gallocin-based anticancer peptides
(ACPs) against epidermal growth factor receptor (EGFR) and vascular epidermal growth factor
receptor (VEGFR) and the evaluation of their pharmacokinetic properties using bioinformatic
approaches.

Methods:

Support vector machine algorithm web-based tools were used for predicting ACPs. The
physicochemical characteristics and the potential of anti-cancer activity of Gallocin-derived ACPs
were determined by in silico tools. The 3D structure of predicted ACPs was modeled using modeling
tools. The interactions between predicted ACPs and targets were investigated by molecular
docking exercises. Then, the stability of ligand-receptor interactions was determined by molecular
dynamic simulation. Finally, ADMET analysis was carried out to check the pharmacokinetic properties
and toxicity of ACPs

Results:

Four amino acid sequences with anti-cancer potential were selected. Through molecular
docking, Pep2, and Pep3 gained the best scores, more binding affinity, and strong attachments by
the formation of reasonable H-bonds with both EGFR and VEGFR. Molecular simulation confirmed
the stability of Pep3- EGFR. According to pharmacokinetic analysis, the ACPs were safe
and truthful.

Conclusion:

Designed peptides can be nominated as drugs for CRC treatment. However, different
in-vitro and in-vivo assessments are required to approve this claim.
Synthesis and Molecular Dynamic Simulation of Novel Cationic and Non-cationic Pyrimidine Derivatives as Potential G-quadruplex-ligands
Authors: Atapour-Mashhad Hoda , Soukhtanloo Mohammad , Golmohammadzadeh Shiva , Chamani Jamshidkhan , Nejabat Mojgan , Hadizadeh Farzin
Published: June 2024

Background:

Drug resistance has been a problem in cancer chemotherapy, which often causes shortterm
effectiveness. Further, the literature indicates that telomere G-quadruplex could be a promising anti-cancer
target.

Objective:

We synthesized and characterized two new pyrimidine derivatives as ligands for G-quadruplex DNA.

Methods:

The interaction of novel non-cationic and cationic pyrimidine derivatives (3a, b) with G-quadruplex
DNA (1k8p and 3qsc) was explored by circular dichroism (CD) and ultraviolet-visible spectroscopy and polyacrylamide
gel electrophoresis (PAGE) methods. The antiproliferative activity of desired compounds was evaluated
by the MTT assay. Apoptosis induction was assessed by Propidium iodide (P.I.) staining and flow cytometry.
Computational molecular modeling (CMM) and molecular dynamics simulation (MD) were studied on the
complexes of 1k8p and 3qsc with the compounds. The van der Waals, electrostatic, polar solvation, solventaccessible
surface area (SASA), and binding energies were calculated and analyzed.

Results:

The experimental results confirmed that both compounds 3a and 3b interacted with 1k8p and 3qsc and
exerted cytotoxic and proapoptotic effects on cancer cells. The number of hydrogen bonds and the RMSD values
increased in the presence of the ligands, indicating stronger binding and suggesting increased structural dynamics.
The electrostatic contribution to binding energy was higher for the cationic pyrimidine 3b, indicating more negative
binding energies.

Conclusion:

Both experimental and MD results confirmed that 3b was more prone to form a complex with DNA
G-quadruplex (1k8p and 3qsc), inhibit cell growth, and induce apoptosis, compared to the non-cationic pyrimidine
3a.
Analysis of Concentrations of Monomethyl Fumarate in Patients with Multiple Sclerosis: Result from Routine Health Care
Authors: Kusnirikova Zuzana Krska , Kacirova Ivana , Pesakova Veronika , Hradilek Pavel , Brozmanova Hana , Grundmann Milan
Published: June 2024

Background:

Dimethyl fumarate is used to treat patients with relapsing-remitting multiple
sclerosis. After ingestion, it is rapidly hydrolyzed to the active primary metabolite monomethyl
fumarate.

Objective:

The main objective of our study was to analyze serum concentrations of monomethyl
fumarate during routine health care in patients with multiple sclerosis treated with a fixed dose of
dimethyl fumarate.

Methods:

In the pilot cross-sectional study, data from 42 patients treated with dimethyl fumarate at
a dose of 240 mg twice daily were collected. Concentrations of the active metabolite monomethyl
fumarate were determined at 1-8 h (median, 3 h) or 10-14 h (median, 13 h) after taking the dose.
The relationship between monomethyl fumarate concentrations and absolute lymphocyte count was
evaluated.

Results:

Concentrations of monomethyl fumarate ranged from 2.5-3177.9 μg/L, with most concentrations
being undetectable approximately 10 hours after administration. In the 1-8 h (median, 3 h)
post-dose subgroup, the concentration/dose ratio ranged widely from 0.04-6.62.
The median concentration of monomethyl fumarate in the group with the absolute lymphocyte count
<0.8 x 10^9/L was more than four times higher than in the group with the absolute lymphocyte
count ≥0.8 x 10^9/L (median 440.1 μg/L versus 98.4 μg/L).

Conclusion:

The wide interindividual variability in monomethyl fumarate pharmacokinetics could
contribute to the differential response to dimethyl fumarate in multiple sclerosis patients. A nonsignificant
but noticeable trend was observed in the relationship of higher serum monomethyl fumarate
concentrations to absolute lymphocyte counts.
Speed Corridor Enforcement System (SCES) - A Case Study of the Highways of Kosovo
Authors: Selimi Bekim , Kizolli Beni , Dedaj Nol
Published: June 2024

Background

Traffic safety remains a significant global concern. Despite advancements in vehicle technology, road infrastructure improvements, and initiatives to raise driver awareness, traffic accidents continue to pose socio-economic problems.

Objectives

The aim of this study was to suggest the potential benefits of implementing a Speed Corridor Enforcement System on highways in Kosovo, aiming to reduce accidents and promote driver awareness.

Methods

To accomplish the stated objective, there is employed a scientific research methodology supported by surveys, statistics, and analysis methods. The sources of information comprise both primary and secondary data, which were gathered from scientific literature, online sources, and relevant studies in the field.

Results

The significant socio-economic challenges arising from traffic accidents are discussed, highlighting the necessity for a comprehensive and multidimensional approach to effectively address this issue. Additionally, the proposal of implementing Speed Control Enforcement Systems on the highways of Kosovo, which are part of Intelligent Transport Systems, is emphasized as a solution. Emphasis is placed on the importance of adopting advanced technological solutions alongside comprehensive strategies to effectively tackle the complex problem of traffic safety.

Conclusion

Considering the alarming 53.41% increase in accidents in Kosovo, the implementation of the speed identification system in corridors could have initially prevented and reduced accidents by a percentage similar to those observed in the reference countries.
Exploring the Influence of Career Interests on Career Adaptability and Gender Differences Within the Groups of Rural Teachers in Hebei, China
Authors: Li Weida , Chang Yuan-Cheng
Published: June 2024

Background

The purpose of this study was to examine the role of career interests in shaping the career adaptability of educators at the primary and secondary levels in rural areas of Hebei Province, China, with a particular emphasis on defining the nuances associated with gender differences.

Methods

The Career Interest Scale and the Career Adaptability Scale were used to conduct a questionnaire survey among teachers from twenty rural schools in Hebei Province. The study sample consisted of 550 rural primary and secondary school teachers. After eliminating invalid questionnaires, a total of 509 valid responses were obtained, of which 256 were from male teachers and 253 from female teachers.

Results

The career interests of rural teachers in Hebei Province, China, have a significant and positive impact on their career adaptability, and an analysis of the differences between male and female teachers indicates that male teachers' career interests exert a greater influence on the career adaptability of male rather than female teachers. Specifically, male teachers tend to focus more on educational aspects in terms of their career interests, and they demonstrate stronger self-confidence in terms of career adaptability.

Conclusion

Hence, rural primary and secondary school teachers in Hebei Province are recommended to take the initiative to reshape their gender perspectives and enhance their career interests to improve their career adaptability and foster continuous professional development.
Research Progress in Natural Products against Liver Fibrosis
Authors: Zhao Siyu , Chen Xin , Tan Rui , Wu Xiaoqing , Jiang Hezhong
Published: June 2024

Fibrosis of the liver is the most common pathological feature of many chronic liver diseases,
progressing to cirrhosis and eventually liver cancer. Currently, only individual genes or proteins
are targeted by synthetic drugs used to treat liver fibrosis, they have limited therapeutic effect,
and are associated with many side effects. In contrast, natural products have shown great advantages
and potential in the treatment of liver fibrosis due to their structural diversity, high multi-target activity
and low toxicity and side effects. Therefore, this review concludes the pathological mechanism of
liver fibrosis and the cellular and signaling pathways involved, provides new ideas for anti-liver fibrosis
research and introduces common natural products and their anti-hepatic fibrosis mechanisms.
Effect of Herbal Medicine on Insulin Signaling Pathways and Insulin Resistance in Metabolic Dysfunction-associated Fatty Liver Disease: A Review
Authors: Karunaratna A.M.D.S. , Ekanayake S.
Published: June 2024

Introduction:

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most
common chronic liver disease progressing towards a substantial global health concern. A multitude
of therapeutic agents are being used to treat MAFLD. The high prevalence and adverse effects of
drugs have increased the global popularity of herbal medicines (HMs) as effective therapeutic agents
to treat MAFLD. Among the causes of pathogenesis, insulin resistance (IR) plays a crucial role in
MAFLD. Hence, the amelioration of IR has emerged as a promising target for potential therapeutic
approaches in MAFLD.

Aim:

This study aimed to explore in vitro and in vivo mechanisms that unveil recent advances in
HMs that target the amelioration of IR in MAFLD.

Materials and Methods:

Electronic databases, including PubMed and MEDLINE, were used to
search literature for HMs in the management or treatment of NAFLD published up to March, 2023.
The three primary search terms were “MAFLD” “NAFLD” and “HM”. MeSH of NAFLD, such as
(Non-alcoholic fatty liver disease, Non-alcoholic Steatohepatitis) and HM (Medicinal plants, Plant
extracts), and keywords were used to optimize the search strategy

Results:

HMs act on a multitude of molecular pathways that increase insulin sensitization including
upregulation of the secretion and activation of insulin receptor substrate (IRS) proteins, upregulation
of phosphatidylinositol 3-kinase (PI3K)/AKT (also known as PKB or protein kinase B) signaling
pathway, activation of the 5' AMP-activated protein kinase (AMPK) pathway and modulation of
enzymes of glucose homeostasis, regeneration of the pancreatic β-cell mass, modulation of secretion
of adipokines, enhancement of the uptake of glucose into tissues via increased expression of GLUT
in tissues, and upregulation of FGF1/FGF1R signaling pathway.

Conclusion:

HMs possess a multitude of potential actions that reduce the IR and improve glucose
homeostasis. Hence, HMs are a promising resource as effective medications for the treatment of
MAFLD.
The Social Media Mirror: Understanding the Distortion of Eating
Habits and Body Image in the Digital Age
Authors: Hussain Md Sadique , Bahl Gurusha , Saraswat Nikita , Agarwal Mohit , Bisht Ajay Singh , Sharma Rahul , Singh Gurvinder , Kumar Rajesh
Published: June 2024

The influence of media on body image and the development of eating disorders
(EDs) has gained increasing attention in contemporary society. This article offers a comprehensive
exploration of the intricate relationship between media exposure, body dissatisfaction,
and disordered eating behaviors. We commence by elucidating the foundational
concepts of body image, EDs, and positive body image, underlining their significance for
both mental and physical well-being. The three most common EDs: anorexia nervosa, bulimia
nervosa, and binge eating disorder (BED), provide an overview of their distinct characteristics.
The article delves into the profound impact of media in shaping contemporary
beauty ideals and propagating unrealistic body expectations. The cause-and-effect relationship
between media messages and body dissatisfaction, with specific attention to the
prevalence of this issue among females in Western cultures has been covered. Furthermore,
we explore the potential predisposing factors associated with media exposure that
contribute to the development of EDs. This review highlights the critical role of media
literacy education in empowering individuals to critically analyse and interpret media content,
enabling them to make informed decisions about their media consumption. In addition,
an attempt has been made to provide insights into the future of media and its impact
on body image, emphasizing the need for ongoing research to better understand the evolving
media landscape. Educators are recognized as pivotal in nurturing healthy body image
among students, and school-based interventions can significantly contribute to promoting
self-esteem, positive body image, and healthy lifestyle choices.
UGC-HRDC: Virtual Learning, Challenges, Opportunities, and Vision for the Future
Authors: Swarna M. Freeda Maria , Khan Shaheed , Ramalingam Panch
Published: June 2024

The Staff development, designing and training, learning and development
(L&D) are very essential in the domain of Higher Education (HE) in India. The
changing of the present day, too, have added a multitude of issues to the Higher
Education Institutions (HEI). At a point in time, the Academic Staff Colleges (ASC)
made the efforts to train the teachers joining the HEI, through orientation programs and
engage the in-service teachers through refresher courses, which made all efforts to
build the capabilities of the teaching community. The explosion in HE with the coming
in of Private Universities, deemed to be Universities, Autonomous Institutions, and
increase in Central Universities, ensured that the L&D for HE teachers became
essential. The ASCs were established by the University Grants Commission (UGC) in
1987 and did yeomen service to the Nation and the HE teaching community after they
came into existence following the recommendations of the then New Education Policy
of 1986 till 2015, when they were rechristened as UGC-Human Resources
Development Centers (UGC-HRDC) and continued to cater to the needs of the faculty
and the administrators of HEI across the country. By 2020, the UGC-HRDCs started to
roll out the Faculty Induction Programmes (FIP) in ten structural modules to help the
faculty members to the newer nuances of the fast-changing dynamics of HE. The
present study is a real-time assessment of the way UGC-HRDCs have taken to virtual
training and adopted to the Hybrid-mode of learning for the benefit of the teaching
communities and administrators. 2023 has been a watershed year for Higher Education,
Teacher capacity building, with the UGC-HRDC being rechristened as UGC-MMTTC,
with an intent to usher in synergy and integration between programs as envisaged by
the Ministry of Education, Government of India.
Pengaruh Media Audiovisual terhadap Minat Ibu Usia Reproduktif Dalam Pemeriksaan Inspeksi Visual Asam Asetat (IVA)
Authors:   Program Studi Sarjana Kebidanan, Fakultas Ilmu Kesehatan, Institut Teknologi, Sains dan Kesehatan RS dr. Soepraoen Malang, Nurkhasanah Riya Ayomi , Retnaningsih Reny ,   ITSK RS dr Soepraoen, Keswara Nila Widya ,   Program Studi Sarjana Kebidanan, Fakultas Ilmu Kesehatan, Institut Teknologi, Sains dan Kesehatan RS dr. Soepraoen Malang, Alim Zainal ,   Program Studi Sarjana Kebidanan, Fakultas Ilmu Kesehatan, Institut Teknologi, Sains dan Kesehatan RS dr. Soepraoen Malang
Published: June 2024

Cervical cancer, which primarily affects women between the ages of 30 and 50, ranks as the second most lethal disease following breast cancer. This disease is correlated with engaging in unprotected sexual activity, individuals who smoke often, and individuals with compromised immune systems. The study revealed that a mere 30% of individuals diagnosed with cervical cancer are identified at an early stage. Individuals who have encountered cervical cancer typically present with an advanced stage of the disease. Efforts aimed at enhancing public awareness and engagement in IVA examinations are primarily facilitated by socialization and health education initiatives. The objective of this study was to investigate the impact of audiovisual media on the level of interest among women of reproductive age in IVA screening. The research design employed for this study was a pre-experimental design with a one-group pre-post-test design. The study population consisted of women of reproductive age who had not undergone screening for IVA. A total of 50 moms were included in the study utilising a complete sampling technique. The study instrument employs a Likert scale for data collection. The Wilcoxon signed ranks test was conducted to examine the hypothesis, with a resulting ρ-value of 0.000, which is less than the predetermined significance level α of 0.05. Therefore, it can be concluded that there is a significant influence of audiovisual media on the interest of women of reproductive age in IVA screening. The incorporation of novel digital technologies, such as audiovisual media, can be regarded as a strategy for promoting health, particularly in the context of cervical cancer screening.
Pembuatan Bioetanol dari Limbah Batang Tembakau Menggunakan Proses Simultaneous Saccharification and Fermentation (SSF)
Authors:   Departemen Teknik Kimia, Fakultas Teknik, Universitas Pembangunan Nasional “Veteran” Jawa Timur, Surabaya, Indonesia, Wulandari Pingky Fantika , Ma’rifah Zustah Damul , Sani Sani , Astuti Dwi Hery
Published: June 2024

The abundance of tobacco stem waste causes environmental problems such as soil and air pollution due to the high levels of nicotine contained in tobacco stems. Therefore, it is necessary to utilize tobacco stem waste to reduce environmental pollution. One way is to use it as a raw material for making bioethanol. The purpose of this study was to determine the effect of fermentation time and cellulase enzyme volume on the level of bioethanol produced. This research uses the process Simultaneous Saccharification and Fermentation (SSF) where in this process hydrolysis and fermentation are carried out in one reactor. Process Simultaneous Saccharification and Fermentation (SSF) was carried out with variations in fermentation time for 24 hours, 48 ​​hours, 72 hours, 96 hours, and 120 hours and variations of cellulase enzymes as much as 6 ml, 7 ml, 8 ml, 9 ml, and 10 ml. The fermented product was tested for density and ethanol content. From the research results, the best bioethanol content was obtained during fermentation for 72 hours with the addition of 10 ml of cellulase enzyme volume which resulted in a bioethanol density of 0.99569 gr/ml and an ethanol content of 18%.
Utilization of FABA Waste (Fly ash Bottom ash) of PLTU Karangkandri as an Adsorbent for Batik Waste Process in Kutawaru Village, Cilacap.
Authors:   Program Studi Teknik Kimia, Universitas Nahdlatul Ulama Al Ghazali, Cilacap, Indonesia, Ramadhani Arnesya , Khuzaimah Siti
Published: June 2024

In this modern era, many technologies are increasingly advanced and industrial developments are increasing, resulting in waste that can contaminate water. The purpose of this study was to determine the best adsorbents from fly ash and bottom ash and to determine the effect of filtration time on the decrease in content, color, BOD5, COD, TSS and pH in the Cilacap batik fabric industrial wastewater treatment process. The steps taken in this study were to find the best filtration time from variations of 60, 120, 180 minutes on fly ash and bottom ash adsorbents and to determine the best adsorbents from fly ash and bottom ash. The results of the color, BOD5, COD, TSS and pH tests showed that the most optimum adsorbent was fly ash, which produced the highest percentage reduction in color content at 60 minutes filtration time of 34.1%, the highest percentage reduction in BOD5 levels at 180 minutes of 69, 5%, the highest percent reduction in COD levels at 120 minutes was 71.5%, the highest percent reduction in TSS levels at 180 minutes was 69.1% and a neutral pH was produced. Analysis of the results of the most optimum time is the filtration time of 180 minutes where the results of filtration using bottom ash adsorbents show the highest percentage reduction in BOD5, COD, TSS levels of 55.4%, 55.3%, 20.4%.
Kinetic Study of Pectin Extraction from Kepok Banana Peel
Authors:   Departemen Teknik Kimia, Fakultas Teknik, Universitas Brawijaya, Malang, Indonesia, Rahmi Isnaini , Fairus Annisa , Dewi Luthfi Kurnia , Nurhadianty Vivi
Published: June 2024

Pectin is one of the polysaccharides that located in plant cell walls along with cellulose, lignin, and hemicellulose. The method for obtaining pectin is extraction. During the extraction process, there is reaction kinetic occur. This study aims to determine the extraction kinetics of kepok banana peel including reaction rate constants and activation energy with variations in extraction time. Secondary data that is processed are 1; 1,5; and 2 of pH extraction, 80oC and 90oC of temperature extraction, time extraction 70, 80, 90, and 100 minutes, and yield of pectin. The result showed that the value of the degradation constant (k2) is smaller than the value of the extraction constant (k1) on all variables. The highest Yemax is 41,88% that was found at pH 1,5; 90oC and 80 minutes of extraction times. The lowest value of activation energy for pectin formation (Ea1) is 17,812 kJ/mol and the highest value of activation energy for pectin degradation (Ea2) is 3,787 kJ/mol, both of which are found at pH 1,5. The optimum conditions for extracting pectin from kepok banana peel were at pH extraction 1,5 and 90oC of temperature extraction taking into account the values of k1, k2, Yemax, tmax, and activation energy.
Exploring the connection between diabetes duration, HbA1c levels, and peripheral neuropathy in type 2 diabetes patients
Authors:   Department of Medical and Surgical Nursing, Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Indonesia, Husna Cut , Akmal Aulia ,   Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Indonesia, Syarif Hilman ,   Department of Emergency Nursing, Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Indonesia, Agustina Sri ,   Department of Pediatric Nursing, Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Indonesia
Published: June 2024

Diabetes mellitus can lead to blood circulation problems, which include both large-scale (macrovascular) and small-scale (microvascular) issues. One specific small-scale problem is the loss of feeling in the feet (known as peripheral neuropathy), which can cause foot ulcers and greatly increase the risk of needing an amputation. The length of time someone has had diabetes and their HbA1c levels (a measure of blood sugar control over time) are linked to the risk of developing diabetic peripheral neuropathy (DPN) in individuals with diabetes. The purpose of this study was to investigate the relationship between how long someone has had type 2 diabetes mellitus (T2DM) and their HbA1c levels with the presence of DPN. We conducted a correlational study with a cross-sectional design. We specifically chose 154 outpatients with T2DM from a hospital clinic for this study. To collect data, we used forms that included demographic information, the Michigan Neuropathy Screening Instrument (MNSI), and the Michigan Diabetic Neuropathy Score (MDNS). We analyzed the data using chi-square tests. Our findings showed a significant link between DPN and both the duration of diabetes and abnormal HbA1c levels in individuals with T2DM, with statistical significance (p=0.001) for both. We suggest that individuals with diabetes should manage their condition carefully to minimize the risk of complications from DPN. It is also recommended that hospitals regularly offer educational programs on neuropathy risks and prevention of severe complications to patients with T2DM.
Incidentes Críticos Como Dispositivos Formativos na Docência Universitária
Authors: Queiroz Sitja Liége Maria
Published: June 2024

Os incidentes críticos, também denominados de “casos de ensino”, são métodos de ensino que partem da análise de casos concretos, ou neles inspirados, com o objetivo de rememorar reflexivamente a cronologia dos eventos buscando compreender as decisões que os tornaram inevitáveis. Como meios de apreensão de vivências, os incidentes críticos são coesos com os paradigmas da compreensão. Pela via da reflexão, os dilemas apresentados são problematizados para que novos ângulos que os constituem possam emergir e compor intervenções melhor refletidas e embasadas. Pretendi avaliar a potencialidade do dispositivo dos incidentes críticos como método de formação pedagógica dos docentes para atuarem na docência universitária. Neste artigo apresento a experiência do trabalho didático com os incidentes críticos em uma turma do componente “Docência Universitária” do Programa de Pós-Graduação em Educação e Contemporaneidade (PPGEduc), da Universidade do Estado da Bahia (UNEB), do semestre 2021.2.
Physical Activity, Body Composition, and Fitness Variables in Adolescents After Periods of Mandatory, Promoted or Nonmandatory, Nonpromoted Use of Step Tracker Mobile Apps: Randomized Controlled Trial
Authors: Mateo-Orcajada Adrián , Vaquero-Cristóbal Raquel , Mota Jorge , Abenza-Cano Lucía
Published: June 2024

Background

It is not known whether an intervention made mandatory as a physical education (PE) class assignment and aimed at promoting physical activity (PA) in adolescents can create a healthy walking habit, which would allow further improvements to be achieved after the mandatory and promoted intervention has been completed.

Objective

The aims of this study were to (1) investigate whether, after a period of using a step tracker mobile app made mandatory and promoted as a PE class assignment, adolescents continue to use it when its use is no longer mandatory and promoted; (2) determine whether there are changes in the PA level, body composition, and fitness of adolescents when the use of the app is mandatory and promoted and when it is neither mandatory nor promoted; and (3) analyze whether the covariates maturity status, gender, and specific app used can have an influence.

Methods

A total of 357 students in compulsory secondary education (age: mean 13.92, SD 1.91 y) participated in the study. A randomized controlled trial was conducted consisting of 2 consecutive 10-week interventions. Participants’ PA level, body composition, and fitness were measured at baseline (T1), after 10 weeks of mandatory and promoted app use (T2), and after 10 weeks of nonmandatory and nonpromoted app use (T3). Each participant in the experimental group (EG) used 1 of 4 selected step tracker mobile apps after school hours.

Results

The results showed that when the use of the apps was neither mandatory nor promoted as a PE class assignment, only a few adolescents (18/216, 8.3%) continued the walking practice. After the mandatory and promoted intervention period (T1 vs T2), a decrease in the sum of 3 skinfolds (mean difference [MD] 1.679; P=.02) as well as improvements in the PA level (MD –0.170; P<.001), maximal oxygen uptake (MD –1.006; P<.001), countermovement jump test (MD –1.337; P=.04), curl-up test (MD –3.791; P<.001), and push-up test (MD –1.920; P<.001) in the EG were recorded. However, the changes between T1 and T2 were significantly greater in the EG than in the control group only in the PA level and curl-up test. Thus, when comparing the measurements taken between T1 and T3, no significant changes in body composition (P=.07) or fitness (P=.84) were observed between the EG and the control group. The covariates maturity status, gender, and specific app used showed a significant effect in most of the analyses performed.

Conclusions

A period of mandatory and promoted use of step tracker mobile apps benefited the variables of body composition and fitness in adolescents but did not create a healthy walking habit in this population; therefore, when the use of these apps ceased to be mandatory and promoted, the effects obtained disappeared.

Trial Registration

ClinicalTrials.gov NCT06164041; https://clinicaltrials.gov/study/NCT06164041
Factors Associated With Surveillance Testing in Individuals With COVID-19 Symptoms During the Last Leg of the Pandemic: Multivariable Regression Analysis
Authors: Dotson Timothy , Price Brad , Witrick Brian , Davis Sherri , Kemper Emily , Whanger Stacey , Hodder Sally , Hendricks Brian
Published: June 2024

Background

Rural underserved areas facing health disparities have unequal access to health resources. By the third and fourth waves of SARS-CoV-2 infections in the United States, COVID-19 testing had reduced, with more reliance on home testing, and those seeking testing were mostly symptomatic.

Objective

This study identifies factors associated with COVID-19 testing among individuals who were symptomatic versus asymptomatic seen at a Rapid Acceleration of Diagnostics for Underserved Populations phase 2 (RADx-UP2) testing site in West Virginia.

Methods

Demographic, clinical, and behavioral factors were collected via survey from tested individuals. Logistic regression was used to identify factors associated with the presence of individuals who were symptomatic seen at testing sites. Global tests for spatial autocorrelation were conducted to examine clustering in the proportion of symptomatic to total individuals tested by zip code. Bivariate maps were created to display geographic distributions between higher proportions of tested individuals who were symptomatic and social determinants of health.

Results

Among predictors, the presence of a physical (adjusted odds ratio [aOR] 1.85, 95% CI 1.3-2.65) or mental (aOR 1.53, 95% CI 0.96-2.48) comorbid condition, challenges related to a place to stay/live (aOR 307.13, 95% CI 1.46-10,6372), no community socioeconomic distress (aOR 0.99, 95% CI 0.98-1.00), no challenges in getting needed medicine (aOR 0.01, 95% CI 0.00-0.82) or transportation (aOR 0.23, 95% CI 0.05-0.64), an interaction between community socioeconomic distress and not getting needed medicine (aOR 1.06, 95% CI 1.00-1.13), and having no community socioeconomic distress while not facing challenges related to a place to stay/live (aOR 0.93, 95% CI 0.87-0.99) were statistically associated with an individual being symptomatic at the first test visit.

Conclusions

This study addresses critical limitations to the current COVID-19 testing literature, which almost exclusively uses population-level disease screening data to inform public health responses.