bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of N+ Implantation on Surface Characteristics of 316L Stainless Steels for Bipolar Plate in PEMFC
Authors: Kim Yu-Sung , Kim Dae-Wook , Lee In-Sik , Yoon Sungook , Kim Daeil , Jun Shinhee , Cha Byung-Chul
Published: June 2020

Nitrogen was implanted into 316L stainless steel by plasma immersion ion implantation (PIII) for surface modification. Due to nitrogen implantation, the corrosion resistance and interfacial contact resistance (ICR) were improved compared to the bare 316L stainless steel. The improved corrosion resistance was attributed to the formation of the expanded austenite phase (γN). The phase formation was found to be closely related to the evolution of the (111) plane texture. The formation of γN is strongly related to applied bias voltages. When bias voltages were increased to 15 kV, the γN phase was partially decomposed due to the formation of excessive nitride, including the CrN phase. For the ICR, increased crystallite size is effective in reducing contact resistance, which might arise from a reduced number of the grain boundary with electron scattering. In particular, the applied bias voltage of 10 kV was the most effective to both corrosion resistance and ICR, and its performance satisfies the demand for a bipolar plate in the Polymer Electrolyte Membrane Fuel Cells (PEMFC).
Electrophoretic Deposition and Characterization of Chitosan/Eudragit E 100 Coatings on Titanium Substrate
Authors: Pawłowski Łukasz , Bartmański Michał , Strugała Gabriel , Mielewczyk-Gryń Aleksandra , Jażdżewska Magdalena , Zieliński Andrzej
Published: June 2020

Currently, a significant problem is the production of coatings for titanium implants, which will be characterized by mechanical properties comparable to those of a human bone, high corrosion resistance, and low degradation rate in the body fluids. This paper aims to describe the properties of novel chitosan/Eudragit E 100 (chit/EE100) coatings deposited on titanium grade 2 substrate by the electrophoretic technique (EPD). The deposition was carried out for different parameters like the content of EE100, time of deposition, and applied voltage. The microstructure, surface roughness, chemical and phase composition, wettability, mechanical and electrochemical properties, and degradation rate at different pH were examined in comparison to chitosan coating without the addition of Eudragit E 100. The applied deposition parameters significantly influenced the morphology of the coatings. The chit/EE100 coating with the highest homogeneity was obtained for Eudragit content of 0.25 g, at 10 V, and for 1 min. Young’s modulus of this sample (24.77 ± 5.50 GPa) was most comparable to that of human cortical bone. The introduction of Eudragit E 100 into chitosan coatings significantly reduced their degradation rate in artificial saliva at neutral pH while maintaining high sensitivity to pH changes. The chit/EE100 coatings showed a slightly lower corrosion resistance compared to the chitosan coating, however, significantly exceeding the substrate corrosion resistance. All prepared coatings were characterized by hydrophilicity.
Sulfur and Oxygen Effects on High-Si Ductile Iron Casting Skin Formation
Authors: Anca Denisa , Chisamera Mihai , Stan Stelian , Stan Iuliana , Riposan Iulian
Published: June 2020

The main objective of the present paper is to evaluate by thermal (cooling curve) analysis the solidification pattern and the occurrence of the layer of degenerate graphite at the surface of ductile iron castings (3.15% Si, typically as 450-18 grade, ISO 1563/2011), with or without a mold coating, including S or O, and different agents (carbonic material, iron powder), supposed to act to block their diffusion into the iron melt. It is found that the mold coating materials temperately influence the parameters of the solidification cooling curves and, more visibly, the occurrence and the thickness of the undesired skin layer. Different graphite morphologies comparable to the casting body are present, at a large range of thicknesses, from 50 up to 200 µm. The sulfur presence in the mold coating will promote a higher skin thickness compared to oxygen (up to 50% by oxygen and 2.5–3.3 times for sulfur action), despite the fact that in the casting body, the graphite nodularity undergoes a limited decrease (from 85% up to 82%–83% level). Carbonic material or iron powder supplementary addition decreases these undesired effects, but the solidification undercooling compared to the equilibrium system is increased. It is found that carbonic material is more efficient at limiting oxygen than iron powder is at limiting the negative effects of sulfur on the casting skin thickness. More experiments are necessary to quantify their capacity to block the oxygen or sulfur transfer into the iron melt.
Machine Learning Techniques with ECG and EEG Data: An Exploratory Study
Authors: Ponciano Vasco , Pires Ivan Miguel , Ribeiro Fernando Reinaldo , Garcia Nuno M. , Villasana María Vanessa , Zdravevski Eftim , Lameski Petre
Published: June 2020

Electrocardiography (ECG) and electroencephalography (EEG) are powerful tools in medicine for the analysis of various diseases. The emergence of affordable ECG and EEG sensors and ubiquitous mobile devices provides an opportunity to make such analysis accessible to everyone. In this paper, we propose the implementation of a neural network-based method for the automatic identification of the relationship between the previously known conditions of older adults and the different features calculated from the various signals. The data were collected using a smartphone and low-cost ECG and EEG sensors during the performance of the timed-up and go test. Different patterns related to the features extracted, such as heart rate, heart rate variability, average QRS amplitude, average R-R interval, and average R-S interval from ECG data, and the frequency and variability from the EEG data were identified. A combination of these parameters allowed us to identify the presence of certain diseases accurately. The analysis revealed that the different institutions and ages were mainly identified. Still, the various diseases and groups of diseases were difficult to recognize, because the frequency of the different diseases was rare in the considered population. Therefore, the test should be performed with more people to achieve better results.
Infrared Optical Conductivity of Bulk Bi2Te2Se
Authors: Zhukova Elena S. , Zhang Hongbin , Martovitskiy Victor P. , Selivanov Yurii G. , Gorshunov Boris P. , Dressel Martin
Published: June 2020

Mid- and near-infrared measurements reveal that the optical conductivity of the three-dimensional topological insulator, Bi2Te2Se, is dominated by bulk carriers and shows a linear-in-frequency increase at 0.5 to 0.8 eV. This linearity might be interpreted as a signature of three-dimensional (bulk) Dirac bands; however, band-structure calculations show that transitions between bands with complex dispersion contribute instead to the inter-band optical conductivity at these frequencies and, hence, the observed linearity is accidental. These results warn against the oversimplified interpretations of optical-conductivity measurements in different Dirac materials.
Overexpression of EIF5A2 Predicts Poor Prognosis in Patients with Oral Squamous Cell Carcinoma
Authors: Lin Yueh-Min , Chen Mei-Ling , Chen Chia-Lo , Yeh Chung-Min , Sung Wen-Wei
Published: June 2020

Oral squamous cell carcinoma (OSCC) is the most common epithelial malignancy affecting the oral cavity, and it is especially significant in Asian countries. Patients diagnosed with OSCC have an unfavorable prognosis and additional prognostic markers would help improve therapeutic strategies. We sought to investigate the association between eukaryotic translation initiation factor 5A2 (EIF5A2) and epithelial–mesenchymal transition (EMT) markers as well as the prognostic significance of EIF5A2 in OSCC. The expression of EIF5A2 and EMT markers was measured through the immunohistochemical staining of specimens from 272 patients with OSCC. In addition, the correlation between different clinicopathological factors and EIF5A2 expression was analyzed. The prognostic role of EIF5A2 was then analyzed via Kaplan–Meier analysis and Cox proportional hazard models. Among the 272 patients, high EIF5A2 expression was significantly associated with an advanced N value (p = 0.008). High tumor expression of EIF5A2 was prone to the expression of low E-cadherin and high beta-catenin (p = 0.046 and p = 0.020, respectively). Patients with high EIF5A2 expression had unfavorable five-year survival rates as compared with those with low expression (49.7% and 67.3%, respectively). The prognostic role of EIF5A2 was further confirmed through multivariate analysis (hazard ratio = 1.714, 95% confidence interval: 1.134–2.590, p = 0.011). High EIF5A2 expression is associated with an advanced N value and EMT markers and may serve as a marker for an unfavorable prognosis in patients with OSCC.
Value of Serum NEUROG1 Methylation for the Detection of Advanced Adenomas and Colorectal Cancer
Authors: Otero-Estévez Olalla , Gallardo-Gomez María , Páez de la Cadena María , Rodríguez-Berrocal Francisco Javier , Cubiella Joaquín , Hernandez Ramirez Vicent , García-Nimo Laura , De Chiara Loretta
Published: June 2020

Aberrant DNA methylation detected in liquid biopsies is a promising approach for colorectal cancer (CRC) detection, including premalignant advanced adenomas (AA). We evaluated the diagnostic capability of serum NEUROG1 methylation for the detection of AA and CRC. A CpG island in NEUROG1 promoter was assessed by bisulfite pyrosequencing in a case-control cohort to select optimal CpGs. Selected sites were evaluated through a nested methylation-specific qPCR custom assay in a screening cohort of 504 asymptomatic family-risk individuals. Individuals with no colorectal findings and benign pathologies showed low serum NEUROG1 methylation, similar to non-advanced adenomas. Contrarily, individuals bearing AA or CRC (advanced neoplasia—AN), exhibited increased NEUROG1 methylation. Using >1.3518% as NEUROG1 cut-off (90.60% specificity), 33.33% of AN and 32.08% of AA were identified, detecting 50% CRC cases. Nonetheless, the combination of NEUROG1 with fecal immunochemical test (FIT), together with age and gender through a multivariate logistic regression resulted in an AUC = 0.810 for AN, and 0.796 for AA, detecting all cancer cases and 35–47% AA (specificity 98–95%). The combination of NEUROG1 methylation with FIT, age and gender demonstrated a convenient performance for the detection of CRC and AA, providing a valuable tool for CRC screening programs in asymptomatic individuals.
Current Concepts of Laser–Oral Tissue Interaction
Authors: Parker Steven , Cronshaw Mark , Anagnostaki Eugenia , Mylona Valina , Lynch Edward , Grootveld Martin
Published: June 2020

Fundamental to the adjunctive use of laser photonic energy for delivering therapy and tissue management, is the ability of the incident energy to be absorbed by target tissues. The aim of this review is to examine the differential performance of the separate components of oral hard and soft tissues when exposed to laser photonic irradiance of variable wavelengths and power values. Through an examination of peer-reviewed published data and materials, the interaction of laser photonic energy and target tissues are explored in detail. Varying laser wavelength emissions relative to anatomical structures explores the ability to optimise laser–tissue interactions, and also identifies possible risk scenarios as they apply to adjacent non-target structures. The concepts and practical aspects of laser photonic energy interactions with target oral tissues are clearly demonstrated. Emphasis was placed on optimising the minimum level of laser power delivery in order to achieve a desired tissue effect, whilst minimising the risk or outcome of collateral tissue damage.
Exploring of a Small-Scale Tourism Product under Economic Instability: The Case of a Greek Rural Border Area
Authors: Chatzitheodoridis Fotios , Kontogeorgos Achilleas
Published: June 2020

The Regional Unit of Kastoria is a rural area in Northwestern Greece, located on the borderline with Albania. Kastoria city, the capital and the largest city of the Kastoria Regional Unit, is known for the production of high-quality fur products. The fur industry has faced a marked crisis from the 1980s onwards, which has contributed to pushing the local economy towards the development of tourism. However, the tourism industry, developed during the last 20 years, has an undefined character. Specifically, tourism is characterized as small-scaled owing to the limited number of mainly domestic tourists, who, in combination with the economic crisis of the last decade, slowed down the initial accelerated trend. The purpose of this paper is to capture the opinions and attitude of Kastoria visitors towards tourism, as well as to illustrate the changes as a consequence of the economic crisis. In this context, a survey was carried out in two periods (in 2008 at the beginning of economic crisis and in 2017 at the end of this crisis) using a structured questionnaire and with a sample of 232 visitors in total. Our findings are highlighted in an effort for policy makers and marketing planners to formulate appropriate marketing strategies and to reconstruct and promote the local touristic product and attract visitors in these border areas.
The Development of Pedagogical Content Knowledge about Teaching Redox Reactions in German Chemistry Teacher Education
Authors: Goes Luciane F. , Fernandez Carmen , Eilks Ingo
Published: June 2020

This paper presents a qualitative cross-level study with a focus on prospective and in-service teachers’ pedagogical content knowledge (PCK) of redox reactions in Germany. The objective was to investigate and analyze the differences in PCK between those in pre-service teacher education and those working as teachers. The sample included four different groups: bachelor’s students, master’s students, graduate teacher trainees, and in-service teachers. Data were collected by an online questionnaire and semi-structured interviews. The online questionnaire was developed based on misconceptions and learning difficulties regarding redox reactions. Sixty-two participants answered the questionnaire and the interviews were carried out with twelve participants. The results revealed that teaching experience makes a difference. Pre-service teachers described quite traditional and content-focused approaches while experienced teachers emphasized the application of the content. Experienced teachers showed a more developed repertoire of instructional strategies. Participants differed also in their knowledge about learners and the curriculum. Concerning assessment, practices were at a quite general pedagogical knowledge level and not domain-specific. Although teacher education in Germany includes several chances for internships, it is suggested that central aspects of teachers’ PCK start to develop and settle only when they begin to work as teachers. To avoid perpetuating traditional practices, investment in continuous professional development is needed.
Design of Differential Variable-Gain Transimpedance Amplifier in 0.18 µm SiGe BiCMOS
Authors: Lee Samuel B.S. , Liu Hang , Yeo Kiat Seng , Chen Jer-Ming , Yu Xiaopeng
Published: June 2020

This paper presents two new inductorless differential variable-gain transimpedance amplifiers (DVGTIA) with voltage bias controlled variable gain designed in TowerJazz’s 0.18 µm SiGe BiCMOS technology (using CMOS transistors only). Both consist of a modified differential cross-coupled regulated cascode preamplifier stage and a cascaded amplifier stage with bias-controlled gain-variation and third-order interleaving feedback. The designs have wide measured transimpedance gain ranges of 24.5–60.6 dBΩ and 27.8–62.8 dBΩ with bandwidth above 6.42 GHz and 5.22 GHz for DVGTIA designs 1 and 2 respectively. The core power consumptions are 30.7 mW and 27.5 mW from a 1.8 V supply and the input referred noise currents are 10.3 pA/√Hz and 21.7 pA/√Hz. The DVGTIA designs 1 and 2 have a dynamic range of 40.4 µA to 3 mA and 76.8 µA to 2.7 mA making both suitable for real photodetectors with an on-chip photodetector capacitive load of 250 fF. Both designs are compact with a core area of 100 µm × 85 µm.
Towards Efficient Neuromorphic Hardware: Unsupervised Adaptive Neuron Pruning
Authors: Guo Wenzhe , Yantır Hasan Erdem , Fouda Mohammed E. , Eltawil Ahmed M. , Salama Khaled Nabil
Published: June 2020

To solve real-time challenges, neuromorphic systems generally require deep and complex network structures. Thus, it is crucial to search for effective solutions that can reduce network complexity, improve energy efficiency, and maintain high accuracy. To this end, we propose unsupervised pruning strategies that are focused on pruning neurons while training in spiking neural networks (SNNs) by utilizing network dynamics. The importance of neurons is determined by the fact that neurons that fire more spikes contribute more to network performance. Based on these criteria, we demonstrate that pruning with an adaptive spike count threshold provides a simple and effective approach that can reduce network size significantly and maintain high classification accuracy. The online adaptive pruning shows potential for developing energy-efficient training techniques due to less memory access and less weight-update computation. Furthermore, a parallel digital implementation scheme is proposed to implement spiking neural networks (SNNs) on field programmable gate array (FPGA). Notably, our proposed pruning strategies preserve the dense format of weight matrices, so the implementation architecture remains the same after network compression. The adaptive pruning strategy enables 2.3× reduction in memory size and 2.8× improvement on energy efficiency when 400 neurons are pruned from an 800-neuron network, while the loss of classification accuracy is 1.69%. And the best choice of pruning percentage depends on the trade-off among accuracy, memory, and energy. Therefore, this work offers a promising solution for effective network compression and energy-efficient hardware implementation of neuromorphic systems in real-time applications.
Benchmark of Rotor Position Sensor Technologies for Application in Automotive Electric Drive Trains
Authors: Datlinger Christoph , Hirz Mario
Published: June 2020

Rotor shaft position sensors are required to ensure the efficient and reliable control of Permanent Magnet Synchronous Machines (PMSM), which are often applied as traction motors in electrified automotive powertrains. In general, various sensor principles are available, e.g., resolvers and inductive- or magnetoresistive sensors. Each technology is characterized by strengths and weaknesses in terms of measurement accuracy, space demands, disturbing factors and costs, etc. Since the most frequently applied technology, the resolver, shows some weaknesses and is relatively costly, alternative technologies have been introduced during the past years. This paper investigates state-of-the-art position sensor technologies and compares their potentials for use in PMSM in automotive powertrain systems. The corresponding evaluation criteria are defined according to the typical requirements of automotive electric powertrains, and include the provided sensor accuracy under the influence of mechanical tolerances and deviations, integration size, and different electrical- and signal processing-related parameters. The study presents a mapping of the potentials of different rotor position sensor technologies with the target to support the selection of suitable sensor technologies for specified powertrain control applications, addressing both system design and components development.
Effect of Degradation on Wood Hygroscopicity: The Case of a 400-Year-Old Coffin
Authors: García-Iruela Alberto , García Esteban Luis , García Fernández Francisco , de Palacios Paloma , Rodriguez-Navarro Alejandro B. , Sánchez Luis Gil , Hosseinpourpia Reza
Published: June 2020

The hygroscopicity and thermodynamic properties of Pinus sylvestris L. wood from a coffin allegedly holding the remains of famous Spanish author Miguel de Cervantes Saavedra (1547–1616) were studied using the 15 °C and 35 °C isotherms fitted to the Guggenheim–Anderson–de Boer model and comparing them with the isotherms of recently felled wood of the same species. In addition, using infrared spectroscopy (FTIR-ATR) and X-ray diffractograms, the functional groups were determined and the crystallinity and organization of the cell wall components were analyzed. The absence of the 1740 cm−1 group indicates hemicellulose degradation in the archaeological wood, and the X-ray diffractograms show a considerable decrease in cellulose crystallinity and disorganization of the cellulose crystallites. The greater availability of active –OH groups means that the archaeological wood isotherms are above the juvenile and mature wood isotherms, and therefore the thermodynamic balance in the sorption of the archaeological wood is greater.
Physical and Mechanical Properties of Fast Growing Polyploid Acacia Hybrids (A. auriculiformis × A. mangium) from Vietnam
Authors: Duc Viet Dang , Ma Te , Inagaki Tetsuya , Tu Kim Nguyen , Quynh Chi Nghiem , Tsuchikawa Satoru
Published: June 2020

Acacia plants are globally important resources in the wood industry, but particularly in Southeast Asian countries. In the present study, we compared the physical and mechanical properties of polyploid Acacia (3x and 4x) clones with those of diploid (2x) clones grown in Vietnam. We randomly selected 29 trees aged 3.8 years from different taxa for investigation. BV10 and BV16 clones represented the diploid controls; X101 and X102 were the triploid clones; and AA-4x, AM-4x, and AH-4x represented neo-tetraploid families of Acacia auriculiformis, Acacia mangium, and their hybrid clones. The following metrics were measured in each plant: stem height levels, basic density, air-dry equilibrium moisture content, modulus of rupture (MOR), modulus of elasticity (MOE), compression strength, and Young’s modulus. We found that the equilibrium moisture content significantly differed among clones, and basic density varied from pith-to-bark and in an axial direction. In addition, the basic density of AA-4x was significantly higher than that of the control clones. Furthermore, the MOR of AM-4x was considerably lower than the control clones, whereas the MOE of X101 was significantly higher than the control values. The compression strength of AM-4x was significantly lower than that of the control clones, but AH-4x had a significantly higher Young’s modulus. Our results suggest that polyploid Acacia hybrids have the potential to be alternative species for providing wood with improved properties to the forestry sector of Vietnam. Furthermore, the significant differences among the clones indicate that opportunities exist for selection and the improvement of wood quality via selective breeding for specific properties.
Optimized Live Feed Regime Significantly Improves Growth Performance and Survival Rate for Early Life History Stages of Pangasius Catfish (Pangasianodon hypophthalmus)
Authors: Vu Ngoc-Ut , Huynh Truong-Giang
Published: June 2020

This study aimed to determine the optimal live feed regime (i.e., initial feeding moment, density, and frequency) for maximum growth and survival of pangasius catfish (Pangasianodon hypophthalmus) early life history stages. The first experiment assessed the optimal initial feeding moment (30, 36, 42, and 48 h post hatching, hph). The second experiment assessed feeding density (3, 5, 8 and 11 individuals per mL, ind/mL) at the optimal initial feeding moment (30 hph) which was the best result from the first experiment. The third experiment assessed optimal feeding frequency (1, 2, 4, and 6 times per day) at the optimal initial feeding moment (30 hph) and density (8 ind/mL) which was drawn upon from the second experiment. All experiments were conducted in 20 L containers containing 20 hph P. hypophthalmus larvae at a density of 10 ind/L and fed rotifers (Brachionus angularis) for 3 days and then water fleas (Moina macrocopa) for 7 days. The first experiment demonstrated that larvae initially fed at 30 hph exhibited a significantly higher survival rate (24%) than larvae initially fed at 36, 42, and 48 hph (19%, 16%, and 16%), respectively. The second experiment demonstrated that larvae fed at 8 and 11 ind/mL densities exhibited significantly higher survival rates (32% and 32%) than larvae fed at 3 and 5 ind/mL densities (13% and 23%), respectively. The third experiment demonstrated that the highest survival rate (66%) was obtained when larvae were fed 6 times per day. These results provide valuable insights regarding the optimal live feed regime for better growth and survival of P. hypophthalmus larvae, which are commercially important and numerously cultured throughout the Mekong Delta region.
Review of Fly-Ash-Based Geopolymers for Soil Stabilisation with Special Reference to Clay
Authors: Abdullah Hayder H. , Shahin Mohamed A. , Walske Megan L.
Published: June 2020

Alkali-activated binders, more commonly referred to as “geopolymers”, have recently emerged as a good alternative to traditional binders (e.g., lime and cement) for soil stabilisation. Geopolymers utilise the alkaline activation of industrial waste to form cementitious products within treated soils, leading to enhanced soil properties. This paper aims to present a review of the use of fly-ash-based geopolymers for soil stabilisation, with special reference to clay. The paper provides some detailed chemical and geotechnical cross-disciplinary knowledge, which advances fly-ash geopolymer as an eco-friendly binder. The paper covers the salient features of the geopolymer treatment process, including key affecting factors, envisioned applications, potential advantages and major limitations. The paper also discusses the main challenges standing against the wide recognition of this technique for soil stabilisation by industry. The paper finally concludes that fly-ash geopolymer can be used successfully as a binder for soil stabilisation; however, further research is still needed to realise the full potential of this promising technique in the future.
Improving Efficiency Assessment of Psychiatric Halfway Houses: A Context-Dependent Data Envelopment Analysis Approach
Authors: Shen Chien-Wen , Hsu Chin-Hsing , Lung For-Wey , Ly Pham Thi Minh
Published: June 2020

This study proposes the approach of context-dependent data envelopment analysis (DEA) to measure operating performance in halfway houses to enable suitable adjustments at the current economic scale. The proposed approach can be used to discriminate the performance of efficient halfway houses and provide more accurate DEA results related to the performance of all halfway houses in a region or a country. The relative attractiveness and progress were also evaluated, and individual halfway houses’ competitive advantage and potential competitors could be determined. A case study of 38 halfway houses in Taiwan was investigated by our proposed approach. Findings suggest that fifteen halfway houses belong to the medium level, which can be classified into a quadrant by examining both their attractiveness score and progress score. The results can be used to allocate community resources to improve the operational directions and develop incentives for halfway houses with attractive and progressive values, which can reduce the institutionalization and waste of medical resources caused by the long-term hospitalization of patients with mental illnesses. Our proposed approach can also provide references for operators and policy makers to improve the management, accreditation, and resource allocation of institutions.
Preliminary Thermal Investigations of Calcium Antimonate Opacified White Glass Tesserae
Authors: Boschetti Cristina , Leonelli Cristina , Rosa Roberto , Romagnoli Marcello , Valero Tévar Miguel Ángel , Schibille Nadine
Published: June 2020

Calcium antimonate (in the hexagonal or cubic form) dispersed in the glass matrix is an artificially synthesized phase commonly documented as opacifier for white glasses during the Roman period. Glasses of this type occasionally contain variable amounts of lead oxide. There is no consensus about the origin and role of the lead component in white glasses, whether it was functional to modify the workability of the glass and/or to help the precipitation of the particles, or whether it was an unintentional pollutant introduced with the raw materials. A group of lead and lead-free white mosaic tesserae from the fourth-century CE villa of Noheda in Spain were analyzed by differential scanning calorimetry (DSC) and high temperature X-ray diffraction (HTXRD) to evaluate the impact of variable amounts of lead oxide in the precipitation of calcium antimonate on the viscosity of the glass. The analyzed glasses show thermal events that have been related to the composition of the glass via multicomponent linear regression model. CaSb2O6 and Ca2Sb2O7 formed in the glass during the cooling phase and the glass was not reheated. Lead oxide influences the thermal behavior of the glass, lowering the onset temperatures of all the events, implying a more cost-effective production process. We propose that lead was added intentionally or that lead-bearing raw materials were selected specifically by the ancient glass artisans.
Bibliometric Analysis of Research on Telomere Length in Children: A Review of Scientific Literature
Authors: Valera-Gran Desirée , Prieto-Botella Daniel , Peral-Gómez Paula , Hurtado-Pomares Miriam , Sánchez-Pérez Alicia , Navarrete-Muñoz Eva-María
Published: June 2020

Telomere length in early life has been recently associated with biological aging and development of negative consequences in later adult life. A relevant area of research has emerged to understand the factors that impact telomere length in children. We conducted a bibliometric analysis to track research output and identify global trends and gaps in the knowledge of telomere length in children. Bibliographic data were retrieved from the Web of Science database and then analyzed by using Bibliometrix R package. A total of 840 publications were yielded from 1991 to 2019. The references were prominently published in journals, with 20 high ranked journals contributing to 30% of literature on telomere length in children. The USA was the most productive country (35.7%), followed by Europe (12.1%), and Asia (11.9%). A knowledge map of telomere length in children through keyword analyses revealed that there were two potential main lines of research based on two different approaches: genomic research and epidemiological research. This study shows that telomere length in children is a topic of research that has gained significant relevance in the last decade. This bibliometric study may be helpful in identifying research trends and finding research hot spots and gaps in this research field.
Supervised Machine Learning Algorithms for Bioelectromagnetics: Prediction Models and Feature Selection Techniques Using Data from Weak Radiofrequency Radiation Effect on Human and Animals Cells
Authors: Halgamuge Malka N.
Published: June 2020

The emergence of new technologies to incorporate and analyze data with high-performance computing has expanded our capability to accurately predict any incident. Supervised Machine learning (ML) can be utilized for a fast and consistent prediction, and to obtain the underlying pattern of the data better. We develop a prediction strategy, for the first time, using supervised ML to observe the possible impact of weak radiofrequency electromagnetic field (RF-EMF) on human and animal cells without performing in-vitro laboratory experiments. We extracted laboratory experimental data from 300 peer-reviewed scientific publications (1990–2015) describing 1127 experimental case studies of human and animal cells response to RF-EMF. We used domain knowledge, Principal Component Analysis (PCA), and the Chi-squared feature selection techniques to select six optimal features for computation and cost-efficiency. We then develop grouping or clustering strategies to allocate these selected features into five different laboratory experiment scenarios. The dataset has been tested with ten different classifiers, and the outputs are estimated using the k-fold cross-validation method. The assessment of a classifier’s prediction performance is critical for assessing its suitability. Hence, a detailed comparison of the percentage of the model accuracy (PCC), Root Mean Squared Error (RMSE), precision, sensitivity (recall), 1 − specificity, Area under the ROC Curve (AUC), and precision-recall (PRC Area) for each classification method were observed. Our findings suggest that the Random Forest algorithm exceeds in all groups in terms of all performance measures and shows AUC = 0.903 where k-fold = 60. A robust correlation was observed in the specific absorption rate (SAR) with frequency and cumulative effect or exposure time with SAR×time (impact of accumulated SAR within the exposure time) of RF-EMF. In contrast, the relationship between frequency and exposure time was not significant. In future, with more experimental data, the sample size can be increased, leading to more accurate work.
The Status of First Aid and Its Associations with Health Outcomes among Patients with Traffic Accidents in Urban Areas of Vietnam
Authors: Mai Hue Thi , Vu Hai Minh , Ngo Tam Thi , Vu Giang Thu , Nguyen Huong Lan Thi , Hoang Men Thi , Tran Bach Xuan , Latkin Carl A. , Ho Cyrus S. H. , Ho Roger C. M.
Published: June 2020

While it is well-evident that proper first aid would significantly promote survival and later treatment outcomes, little attention has been paid to improving its capacity in Vietnam. Thus, we conducted this study to assess the status of first aid and its associations with health outcomes among patients in traffic accidents in urban areas of Vietnam. We conducted a cross-sectional study on 413 patients in traffic accidents from October to December 2018 at six hospitals in Thai Binh province. Socio-demographics, first aid characteristics, and health outcomes were collected via face-to-face interviews using a structured questionnaire. We used a chi-square test to determine the differences in health outcomes among those who received first aid and those without. In addition, a multivariable regression was performed to determine the factors associated with first aid. The results indicated that less than half of the patients received first aid (48.1%), and only one fourth received first aid within 10 min after an accident. The proportions of having problems with mobility, self-care, usual activities, and pain/discomfort were significantly lower among those who received first aid compared to those without it. The regression model showed that those with multiple injuries were less likely to receive first aid.
Perceived Discrimination, Psychological Distress and Cardiovascular Risk in Migrants in Spain
Authors: Martos-Méndez María José , García-Cid Alba , Gómez-Jacinto Luis , Hombrados-Mendieta Isabel
Published: June 2020

The aim of the present study is to determine the effect of discrimination and psychological distress on the cardiovascular health of immigrants, as well as to analyse potential differences based on age, gender, length of residence in host country and geographic origin. The sample was formed by 1714 immigrants from Africa, Eastern Europe and Latin America. Of the sample, 48.7% were men and 51.3% were women. Most relevant results show that discrimination (t = 4.27; p = 0.000) and psychological distress (t = 4.35; p = 0.000) experienced by immigrants predict their cardiovascular risk. Furthermore, psychological distress mediates the relation between discrimination and risk (t = 4.03; p = 0.000). Significant differences between men and women were found, as well as differences based on ethnicity, although to a lesser extent. Age affects the relation between discrimination, psychological distress and arterial hypertension and hypercholesterolemia. Results are notably relevant for the design of preventive health programmes for immigrants and intervention strategies in order to prevent diseases that may imply cardiovascular risks and seriously affect immigrants’ health.
Obesity in Young Adulthood: The Role of Physical Activity Level, Musculoskeletal Pain, and Psychological Distress in Adolescence (The HUNT-Study)
Authors: Guddal Maren Hjelle , Stensland Synne Øien , Småstuen Milada Cvancarova , Johnsen Marianne Bakke , Heuch Ingrid , Zwart John-Anker , Storheim Kjersti
Published: June 2020

The global obesity epidemic raises long-term health concerns which underline the importance of preventive efforts. We aimed to investigate individual and combined effects of common health problems in adolescence on the probability of obesity in young adulthood. This prospective population-based study included data from participants in the Nord-Trøndelag Health Study in Norway (Young-HUNT1 (1995–1997), age 13–19, baseline) who participated in HUNT3 as young adults 11 years later (age 23–31). Exposure variables at baseline included self-reported physical activity, musculoskeletal pain, and psychological distress. We examined associations between exposure variables and the main outcome of obesity in young adulthood (BMI ≥ 30 kg/m2) using univariate and multiple logistic regression, stratified by sex. Probabilities of obesity for given combinations of the exposure variables were visualized in risk matrixes. The study sample consisted of 1859 participants (43.6% boys). Higher probabilities of obesity in young adulthood were found across combinations of lower physical activity levels and presence of musculoskeletal pain in adolescence. Additional adverse effects of psychological distress were low. Proactive intervention strategies to promote physical activity and facilitate sports participation for all adolescents, whilst addressing musculoskeletal pain and its potential individual causes, could prove helpful to prevent development of obesity in young adulthood.
Associations between Particulate Matter and Otitis Media in Children: A Meta-Analysis
Authors: Lee Sang-Youp , Jang Myoung-jin , Oh Seung Ha , Lee Jun Ho , Suh Myung-Whan , Park Moo Kyun
Published: June 2020

Particulate matter (PM), a primary component of air pollution, is a suspected risk factor for the development of otitis media (OM). However, the results of studies on the potential correlation between an increase in the concentration of PM and risk of developing OM are inconsistent. To better characterize this potential association, a meta-analysis of studies indexed in three global databases (PubMed, EMBASE, and The Cochrane Library) was conducted. These databases were systematically screened for observational studies of PM concentration and the development of OM from the time of their inception to 31 March 2020. Following these searches, 12 articles were analyzed using pooled odds ratios generated from random-effects models to test for an association between an increased concentration of PM and the risk of developing OM. The data were analyzed separately according to the size of particulate matter as PM2.5 and PM10. The pooled odds ratios for each 10 μg/m3 increase in PM2.5 and PM10 concentration were 1.032 (95% confidence interval (CI), 1.005–1.060) and 1.010 (95% CI, 1.008–1.012), respectively. Specifically, the pooled odds ratios were significant within the short-term studies (PM measured within 1 week of the development of OM), as 1.024 (95% CI, 1.008–1.040) for PM2.5 concentration and 1.010 (95% CI, 1.008–1.012) for PM10 concentration. They were significant for children under 2 years of age with pooled odds ratios of 1.426 (95% CI, 1.278–1.519) for an increase in the concentration of PM2.5. The incidence of OM was not correlated with the concentration of PM, but was correlated with an increase in the concentration of PM. In conclusion, an increase in the concentration of PM2.5 is more closely associated with the development of OM compared with an increase in the concentration of PM10; this influence is more substantial in shorter-term studies and for younger children.
Voice-Related Quality of Life in Post-Laryngectomy Rehabilitation: Tracheoesophageal Fistula’s Wellness
Authors: Cocuzza Salvatore , Maniaci Antonino , Grillo Calogero , Ferlito Salvatore , Spinato Giacomo , Coco Salvatore , Merlino Federico , Stilo Giovanna , Santoro Giovanni Paolo , Iannella Giannicola , Vicini Claudio , La Mantia Ignazio
Published: June 2020

(1) Introduction: Laryngeal cancer is one of the most common types of cancer affecting the upper aerodigestive tract. Despite ensuring good oncological outcome in many locoregionally advanced cases, total laryngectomy is associated with relevant physical and psychological sequelae. Treatment through tracheo-esophageal speech, if promising, can lead to very variable outcomes. Not all laryngectomee patients with vocal prosthesis benefit from the same level of rehabilitation mainly due to the development of prosthetic or fistula related problems. The relating sequelae in some cases are even more decisive in the patient quality of life, having a higher impact than communicational or verbal skills. (2) Material and Methods: A retrospective study was conducted on 63 patients initially enrolled with a history of total laryngectomy and voice rehabilitation, treated at the University Hospital of Catania from 1 January 2010 to 31 December 2018. Quality of life (QoL) evaluation through validated self-administrated questionnaires was performed. (3) Results: The Voice-Related Quality of Life questionnaire revealed significantly better outcomes in both socio-emotional and functional domains of the tracheoesophageal patient group compared to the esophageal group (p = 0.01; p = 0.01, respectively), whereas in the Voice Handicap Index assessment, statistically significant scores were not achieved (p = 0.33). (4) Discussion: The significant differences reported through the V-RQOL and Voice Handicap Index scales in the presence of fistula related problems and device lifetime reduction when compared to the oesophageal speech group have demonstrated, as supported by the literature, a crucial role in the rehabilitative prognosis. (5) Conclusions: The criteria of low resistance to airflow, optimal tracheoesophageal retention, prolonged device life, simple patient maintenance, and comfortable outpatient surgery are the reference standard for obtaining good QoL results, especially over time. Furthermore, the correct phenotyping of the patient based on the main outcomes achieved at clinical follow-up guarantees the primary objective of the identification of a better quality of life.
The Effect of Socioeconomic Status on All-Cause Maternal Mortality: A Nationwide Population-Based Cohort Study
Authors: Jeong Wonjeong , Jang Sung-In , Park Eun-Cheol , Nam Jin Young
Published: June 2020

Improving maternal health is one of the 13 targets of Sustainable Development Goal 3; consequently, preventing maternal death, which usually occurs in women’s prime productive years, is an important issue that needs to be addressed immediately. This study examines the association between socioeconomic status and all-cause maternal mortality in South Korea and provides evidence of preventable risk factors for maternal death. For this population-based retrospective cohort study, data on 3,334,663 nulliparous women were extracted from the Korean National Health Insurance Service database between 2003 and 2018. The outcome variables were all-cause maternal mortality within six weeks and a year after childbirth. A log-binomial regression model determined the association between maternal mortality and income-level adjusted covariates. Women with lower income levels had higher risk of maternal death within six weeks (risk ratio (RR) = 2.42, 95% confidence interval (CI) = 1.65–3.53) and within one year (RR = 1.83, 95% CI = 1.47–2.28), especially those who were aged 35–39 years, lived in rural areas, delivered via cesarean section, and had maternal comorbidities. The study identifies a significant relationship between South Korean primiparas’ socioeconomic status and maternal death within six weeks or one year after childbirth, suggesting interventions to alleviate the risk of maternal death.
The Effects of Long-Term Immunosuppressive Therapies on the Structure of the Rat Prostate
Authors: Grabowska Marta , Laszczyńska Maria , Kędzierska-Kapuza Karolina , Kram Andrzej , Gill Kamil , Piasecka Małgorzata
Published: June 2020

Background: Little is known about the overall impact of immunosuppressive drugs on the prostate. The study aimed to determine the impact of different protocols of immunosuppressive treatment on the structure of the rat ventral prostate. Methods: For 6 months, 48 male Wistar rats received immunosuppressive drugs: cyclosporin A, tacrolimus, mycophenolate mofetil, rapamycin, and prednisone, according to three-drug protocols. Light and transmission electron microscopic studies, and quantitative evaluation of immunohistochemical expression of selected intermediate filaments, CD117+ mast cells, and CD138+ plasma cells were performed in the rat ventral prostate. Results: In all experimental groups, acini focal hyperplasia, changes to the ultrastructure of the glandular epithelium, changes in the expression of cytokeratins and desmin, and numerous mast and plasma cells in the prostate stroma were found. In cyclosporine-A-based groups, atrophy and numerous intracellular vacuoles were observed. In groups where a three-drug treatment was replaced with rapamycin, morphological alterations were less severe compared to those without conversion. Conclusions: In the rat ventral prostate, (1) immunosuppressive protocols affect the morphology and immunohistochemical expression of intermediate filaments, (2) morphological alterations, expression, and localization of selected proteins are not connected with adenocarcinoma development, and (3) conversion of the treatment to rapamycin may prevent hyperplastic abnormalities.
Understanding Supporting and Hindering Factors in Community-Based Psychotherapy for Refugees: A Realist-Informed Systematic Review
Authors: Gruner Douglas , Magwood Olivia , Bair Lissa , Duff Liezl , Adel Shiva , Pottie Kevin
Published: June 2020

Culture, tradition, structural violence, and mental health-related stigma play a major role in global mental health for refugees. Our aim was to understand what factors determine the success or failure of community-based psychotherapy for trauma-affected refugees and discuss implications for primary health care programs. Using a systematic realist-informed approach, we searched five databases from 2000 to 2018. Two reviewers independently selected RCTs for inclusion, and we contacted authors to obtain therapy training manuals. Fifteen articles and 11 training manuals met our inclusion criteria. Factors that improved symptoms of depression, anxiety, and PTSD included providing culturally adapted care in a migrant-sensitive setting, giving a role to other clinical staff (task-shifting), and intervention intensity. Precarious asylum status, constraining program monitoring requirements, and diverse socio-cultural and gender needs within a setting may reduce the effectiveness of the program. Primary care programs may enable community based mental health care and may reduce mental health-related stigma for refugees and other migrants. More research is needed on the cultural constructs of distress, programs delivered in primary care, and the role of cultural and language interpretation services in mental health care.