bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanical Properties of Corroded Reinforcement
Authors: Bahleda František , Prokop Jozef , Koteš Peter , Wdowiak-Postulak Agnieszka
Published: March 2023

Reinforced concrete (RC) structures are basically composite elements because they consist of two materials—concrete and reinforcement (reinforcing steel bars). From the point of view of the design of new constructions, it is necessary to design them in such a way as to ensure their reliability, safety and durability throughout their design lifetime, Td. However, all elements, including RC members, are affected by the environment in which they are located. An aggressive environment causes degradation of materials. In the case of reinforcement, corrosion of the reinforcement is considered to be the most well-known and at the same time the most serious way of degradation. From the point of view of existing reinforced concrete elements, it is therefore important to know whether and how the corrosion of the reinforcement affects the mechanical properties of the given reinforcement. The mechanical properties of reinforcement are very important when assessing the actual condition of reinforced concrete (RC) elements, to determine the resistance and load-carrying capacity of the elements. Therefore, it is necessary to investigate the effect of corrosion on mechanical properties of reinforcement. The paper reports on the results of an experimental analysis of the effect of corrosion on the change in the mechanical properties of reinforcement. Furthermore, it presents both the redistribution of mechanical properties along the cross-section of reinforcement, produced by various techniques, such as hot-rolling, hot-rolling with controlled cooling from rerolling temperature and cold-rolled as well as the mechanical properties under the action of corrosion.
Investigating the Use of ChatGPT for the Scheduling of Construction Projects
Authors: Prieto Samuel A. , Mengiste Eyob T. , García de Soto Borja
Published: March 2023

Generative Pre-Trained Transformer (GPT) language models such as ChatGPT have the potential to revolutionize the construction industry by automating repetitive and time-consuming tasks. This paper presents a study in which ChatGPT was used to generate a construction schedule for a simple construction project. The output from ChatGPT was evaluated by a pool of participants that provided feedback regarding their overall interaction experience and the quality of the output. The results show that ChatGPT can generate a coherent schedule that follows a logical approach to fulfill the requirements of the scope indicated. The participants had an overall positive interaction experience and indicated the potential of such a tool in automating many preliminary and time-consuming tasks. However, the technology still has limitations, and further development is needed before it can be widely adopted in the industry. Overall, this study highlights the advantages of using large language models and Natural Language Processing (NLP) techniques in the construction industry and the need for further research.
Microstructure Properties of Popular Alkali-Activated Pastes Cured in Ambient Temperature
Authors: Kamath Muralidhar , Prashant Shreelaxmi , Ralegaonkar Rahul
Published: March 2023

This paper reported on the micro-level properties of alkali-activated pastes cured in ambient conditions. The mechanisms influencing setting time and the microstructure development of fly ash, slag, and metakaolin were studied. The mortar compressive strength of the binders and their ultrasonic pulse velocity (UPV) were tested after 56 days of ambient curing. The micro-level properties of paste cured at ambient conditions for seven days were determined to understand the phases developed. NASH gel was observed to delay setting and possessed lower compressive strength, while CASH gel was set early and possessed high compressive strength. The micro-characterisation of the alkali-activated binder system developed with fly ash and metakaolin showed the presence of NASH gel. The alkali-activated binder system developed with GGBS contained multiple gels, such as N, C-ASH, and CSH. The molecular structures of CSH, CASH, NASH, and N, C-ASH are also presented and were obtained using high score plus software.
Casting a Wider NET: Pancreatic Exocrine Insufficiency Induced by Somatostatin Analogues among Patients with Neuroendocrine Tumours?
Authors: Hall Lewis A. , Powell-Brett Sarah , Thompson Oscar , Smith Daniel , Bradley Elizabeth , Smith Stacey , Vickrage Suzanne , Kemp-Blake Joanne , Roberts Keith J. , Shah Tahir
Published: March 2023

Somatostatin-analogues (SSAs) are a first-line treatment of unresectable neuroendocrine tumours (NETs). However, SSAs inhibit pancreatic secretions, which could lead to pancreatic exocrine insufficiency (PEI). PEI is known to be detrimental to patient quality of life and nutritional status. This study aimed to evaluate the effect of SSAs on pancreatic exocrine function in patients with NETs, using the 13C-mixed triglyceride breath test (13C-MTGT). Exocrine function was assessed using the 13C-MTGT at baseline and after a third SSA injection (two months). A quotient of 13CO2/12CO2 was measured by mass spectrometry, and the cumulative percent dose recovered at 6 h (cPDR) is reported. The secondary endpoints investigated were change in weight, HbA1C, and vitamin D levels. Ten patients completed the study. Exocrine function reduced in all patients (n = 10) following SSA therapy (median reduction from baseline: −23.4% (range: −42.1–0.5%, p = 0.005)). vitamin D levels decreased in all but one patient (median decrease from baseline: −26.5%, (−44.7–10%; p = 0.038)), and median HbA1C levels increased by 8.0% (0–59.3%; p = 0.008). Change in weight was not significant (median decrease from baseline: −0.21% (−4.5–3.5%, p = 1.000)). SSA therapy has a consistent impact on exocrine function from early in the treatment course, but the long-term clinical effects of this remain to be defined. Further studies are required to determine the clinical relevance of this observation and optimise the management of PEI in this cohort.
Empowering the Potential of CAR-T Cell Immunotherapies by Epigenetic Reprogramming
Authors: Alvanou Maria , Lysandrou Memnon , Christophi Panayota , Psatha Nikoleta , Spyridonidis Alexandros , Papadopoulou Anastasia , Yannaki Evangelia
Published: March 2023

T-cell-based, personalized immunotherapy can nowadays be considered the mainstream treatment for certain blood cancers, with a high potential for expanding indications. Chimeric antigen receptor T cells (CAR-Ts), an ex vivo genetically modified T-cell therapy product redirected to target an antigen of interest, have achieved unforeseen successes in patients with B-cell hematologic malignancies. Frequently, however, CAR-T cell therapies fail to provide durable responses while they have met with only limited success in treating solid cancers because unique, unaddressed challenges, including poor persistence, impaired trafficking to the tumor, and site penetration through a hostile microenvironment, impede their efficacy. Increasing evidence suggests that CAR-Ts’ in vivo performance is associated with T-cell intrinsic features that may be epigenetically altered or dysregulated. In this review, we focus on the impact of epigenetic regulation on T-cell differentiation, exhaustion, and tumor infiltration and discuss how epigenetic reprogramming may enhance CAR-Ts’ memory phenotype, trafficking, and fitness, contributing to the development of a new generation of potent CAR-T immunotherapies.
Co-Occurrence of Beckwith–Wiedemann Syndrome and Early-Onset Colorectal Cancer
Authors: Cecere Francesco , Pignata Laura , Hay Mele Bruno , Saadat Abu , D’Angelo Emilia , Palumbo Orazio , Palumbo Pietro , Carella Massimo , Scarano Gioacchino , Rossi Giovanni Battista , Angelini Claudia , Sparago Angela , Cerrato Flavia , Riccio Andrea
Published: March 2023

CRC is an adult-onset carcinoma representing the third most common cancer and the second leading cause of cancer-related deaths in the world. EO-CRC (<45 years of age) accounts for 5% of the CRC cases and is associated with cancer-predisposing genetic factors in half of them. Here, we describe the case of a woman affected by BWSp who developed EO-CRC at age 27. To look for a possible molecular link between BWSp and EO-CRC, we analysed her whole-genome genetic and epigenetic profiles in blood, and peri-neoplastic and neoplastic colon tissues. The results revealed a general instability of the tumor genome, including copy number and methylation changes affecting genes of the WNT signaling pathway, CRC biomarkers and imprinted loci. At the germline level, two missense mutations predicted to be likely pathogenic were found in compound heterozygosity affecting the Cystic Fibrosis (CF) gene CFTR that has been recently classified as a tumor suppressor gene, whose dysregulation represents a severe risk factor for developing CRC. We also detected constitutional loss of methylation of the KCNQ1OT1:TSS-DMR that leads to bi-allelic expression of the lncRNA KCNQ1OT1 and BWSp. Our results support the hypothesis that the inherited CFTR mutations, together with constitutional loss of methylation of the KCNQ1OT1:TSS-DMR, initiate the tumorigenesis process. Further somatic genetic and epigenetic changes enhancing the activation of the WNT/beta-catenin pathway likely contributed to increase the growth advantage of cancer cells. Although this study does not provide any conclusive cause–effect relationship between BWSp and CRC, it is tempting to speculate that the imprinting defect of BWSp might accelerate tumorigenesis in adult cancer in the presence of predisposing genetic variants.
Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review
Authors: Clasen Nikita H.Z. , van der Perk M.E. Madeleine , Neggers Sebastian J.C.M.M. , Bos Annelies M.E. , van den Heuvel-Eibrink Marry M.
Published: March 2023

Background: Childhood cancer patients and their families are increasingly offered oncofertility care including information regarding their risk of gonadal damage by paediatric oncologists, fertility counselling by fertility specialists and fertility preservation options. However, experiences regarding oncofertility care are underreported. We aimed to summarize the available evidence of experiences of female childhood cancer patients and survivors regarding oncofertility care. Methods: Manuscripts were systematically identified using the PubMed and Embase database. From, respectively, 1256 and 3857 manuscripts, 7 articles were included and assessed, including risk of bias assessment. Outcome measures included data describing experiences of female childhood cancer patients and survivors, regarding fertility information, counselling and/or preservation. Results: Female patients and survivors are variably satisfied with fertility information, report challenges in communication with healthcare professionals and prefer to receive general information at diagnosis and detailed fertility information later. Regrets after fertility counselling are underreported, but are associated with refusing fertility preservation. Lastly, regardless of counselling, female patients and survivors report fertility concerns about their future children’s health and effect on relationships. Conclusion: Currently, the satisfaction with oncofertility care varies and female patients or survivors report regrets and concerns regardless of receiving fertility information or counselling. These results may help to improve the content of fertility information, communication skills of healthcare professionals and timing of counselling.
Research Progress of Carbon Deposition on Ni-Based Catalyst for CO2-CH4 Reforming
Authors: Ren Yuan , Ma Ya-Ya , Mo Wen-Long , Guo Jing , Liu Qing , Fan Xing , Zhang Shu-Pei
Published: March 2023

As we all know, the massive emission of carbon dioxide has become a huge ecological and environmental problem. The extensive exploration, exploitation, transportation, storage, and use of natural gas resources will result in the emittance of a large amount of the greenhouse gas CH4. Therefore, the treatment and utilization of the main greenhouse gases, CO2 and CH4, are extremely urgent. The CH4 + CO2 reaction is usually called the dry methane reforming reaction (CRM/DRM), which can realize the direct conversion and utilization of CH4 and CO2, and it is of great significance for carbon emission reduction and the resource utilization of CO2-rich natural gas. In order to improve the activity, selectivity, and stability of the CO2-CH4 reforming catalyst, the highly active and relatively cheap metal Ni is usually used as the active component of the catalyst. In the CO2-CH4 reforming process, the widely studied Ni-based catalysts are prone to inactivation due to carbon deposition, which limits their large-scale industrial application. Due to the limitation of thermodynamic equilibrium, the CRM reaction needs to obtain high conversion and selectivity at a high temperature. Therefore, how to improve the anti-carbon deposition ability of the Ni-based catalyst, how to improve its stability, and how to eliminate carbon deposition are the main difficulties faced at present.
S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720
Authors: Laroche Fabrice J. F. , Li Sheng , Shen Ning , Hwang Soo Kyung , Nguyen Gina , Yu Wenling , Wong Chen Khuan , Quinton Ryan J. , Berman Jason N. , Liu Ching-Ti , Singh Anurag , Ganem Neil J. , Thiagalingam Sam , Feng Hui
Published: March 2023

Hyperactive sphingosine 1-phosphate (S1P) signaling is associated with a poor prognosis of triple-negative breast cancer (TNBC). Despite recent evidence that links the S1P receptor 1 (S1P1) to TNBC cell survival, its role in TNBC invasion and the underlying mechanisms remain elusive. Combining analyses of human TNBC cells with zebrafish xenografts, we found that phosphorylation of S1P receptor 1 (S1P1) at threonine 236 (T236) is critical for TNBC dissemination. Compared to luminal breast cancer cells, TNBC cells exhibit a significant increase of phospho-S1P1 T236 but not the total S1P1 levels. Misexpression of phosphorylation-defective S1P1 T236A (alanine) decreases TNBC cell migration in vitro and disease invasion in zebrafish xenografts. Pharmacologic disruption of S1P1 T236 phosphorylation, using either a pan-AKT inhibitor (MK2206) or an S1P1 functional antagonist (FTY720, an FDA-approved drug for treating multiple sclerosis), suppresses TNBC cell migration in vitro and tumor invasion in vivo. Finally, we show that human TNBC cells with AKT activation and elevated phospho-S1P1 T236 are sensitive to FTY720-induced cytotoxic effects. These findings indicate that the AKT-enhanced phosphorylation of S1P1 T236 mediates much of the TNBC invasiveness, providing a potential biomarker to select TNBC patients for the clinical application of FTY720.
Substances of Natural Origin in Medicine: Plants vs. Cancer
Authors: Gielecińska Adrianna , Kciuk Mateusz , Mujwar Somdutt , Celik Ismail , Kołat Damian , Kałuzińska-Kołat Żaneta , Kontek Renata
Published: March 2023

Continuous monitoring of the population’s health is the main method of learning about disease prevalence. National and international data draw attention to the persistently high rates of cancer incidence. This necessitates the intensification of efforts aimed at developing new, more effective chemotherapeutic and chemopreventive drugs. Plants represent an invaluable source of natural substances with versatile medicinal properties. Multidirectional activities exhibited by natural substances and their ability to modulate key signaling pathways, mainly related to cancer cell death, make these substances an important research direction. This review summarizes the information regarding plant-derived chemotherapeutic drugs, including their mechanisms of action, with a special focus on selected anti-cancer drugs (paclitaxel, irinotecan) approved in clinical practice. It also presents promising plant-based drug candidates currently being tested in clinical and preclinical trials (betulinic acid, resveratrol, and roburic acid).
Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging
Authors: Cheng Mingjia , Yuan Weihao , Moshaverinia Alireza , Yu Bo
Published: March 2023

Advanced age is a shared risk factor for many chronic and debilitating skeletal diseases including osteoporosis and periodontitis. Mesenchymal stem cells develop various aging phenotypes including the onset of senescence, intrinsic loss of regenerative potential and exacerbation of inflammatory microenvironment via secretory factors. This review elaborates on the emerging concepts on the molecular and epigenetic mechanisms of MSC senescence, such as the accumulation of oxidative stress, DNA damage and mitochondrial dysfunction. Senescent MSCs aggravate local inflammation, disrupt bone remodeling and bone-fat balance, thereby contributing to the progression of age-related bone diseases. Various rejuvenation strategies to target senescent MSCs could present a promising paradigm to restore skeletal aging.
Resistin Contribution to Cardiovascular Risk in Chronic Kidney Disease Male Patients
Authors: Romejko Katarzyna , Rymarz Aleksandra , Szamotulska Katarzyna , Bartoszewicz Zbigniew , Rozmyslowicz Tomasz , Niemczyk Stanisław
Published: March 2023

Background: Resistin is a molecule that belongs to the Resistin-Like Molecules family (RELMs), the group of proteins taking part in inflammatory processes. Increased resistin concentrations are observed in cardiovascular complications. Resistin contributes to the onset of atherosclerosis and intensifies the atherosclerotic processes. The aim of this study was to investigate the relationship between resistin and cardiovascular (CV) risk in men with chronic kidney disease (CKD) not treated with dialysis. Materials and Methods: One hundred and forty-two men were included in the study: 99 men with eGFR lower than 60 mL/min/1.73 m2 and 43 men with eGFR ≥ 60 mL/min/1.73 m2. CV risk was assessed. Serum resistin, tumor necrosis factor-alpha (TNF-alpha) and plasminogen activator inhibitor-1 (PAI-1) were measured among other biochemical parameters. Results: We observed that resistin concentrations were significantly higher in patients with CKD compared to individuals with eGFR ≥ 60 mL/min/1.73 m2 (p = 0.003). In CKD, after estimating the general linear model (GLM), we found that resistin is associated with CV risk (p = 0.026) and PAI-1 serum concentrations (0.012). The relationship of PAI-1 with resistin depends on the level of CV risk in CKD (p = 0.048). Conclusions: Resistin concentrations rise with the increase of CV risk in CKD patients and thus resistin may contribute to the progression of cardiovascular risk in this group of patients. The relationship between resistin and CV risk is modified by PAI-1 concentrations.
Targeted Diode Laser Therapy for Oral and Perioral Capillary-Venous Malformation in Pediatric Patients: A Prospective Study
Authors: Tempesta Angela , Dell’Olio Fabio , Siciliani Rosaria Arianna , Favia Gianfranco , Capodiferro Saverio , Limongelli Luisa
Published: March 2023

Background: This study describes the management protocol for capillary-venous malformations in pediatric patients and reports the epidemiology of diagnosed and treated cases at the Unit of Odontostomatology of the Aldo Moro University of Bari from 2014 to 2022. Methods: The authors classified the intraoral and perioral capillary-venous malformations by superficial diameter (<1 cm, 1–3 cm, >3 cm) and ultrasonographical depth extension (≤5 mm, >5 mm). All patients underwent pulsed-mode diode laser transmucosal photocoagulation (8–12 W/cm2); those with malformations that were wide (>3 cm) and deep (>5 mm) received intralesional photocoagulation, too (13 W/cm2). The children received general anesthesia based on their compliance and lesions’ extension. The follow-up lasted six months. Results: A total of 22 females and 14 males (age range 4–18 years) presented 63 capillary-venous malformations. Five patients with Sturge–Weber syndrome, seven with hereditary hemorrhagic telangiectasia, and five with angiomatosis showed multiple malformations. The authors found no intraoperative or postoperative complications. Seventeen patients with lesions >1 cm and >5 mm deep required multiple laser sessions to heal. Conclusion: The results of the current study support diode laser photocoagulation as the gold standard for the treatment of intraoral and perioral capillary-venous malformations in pediatric patients.
Trends in Early Sexual Initiation and Its Association with Socio-Environmental Factors among Korean Adolescents
Authors: Ryu Dong-Hee
Published: March 2023

There has been no research on the trends in early sexual initiation associated with socio-environmental factors in Korea. This study aimed to examine the trends of early sexual initiation with various socio-environmental factors among adolescents. The Korea Youth Risk Behavior Web-based Survey data were used, and two pooled datasets extracted from the 2006–2008 and 2014–2016 waves were conducted and compared. In this study, early sexual initiation was defined as sexual intercourse at the age of 13 years or younger. The weighted percentage and 95% confidence interval reporting early sexual initiation were estimated, and multiple logistic regression was performed for each subgroup of socio-environmental variables with the 2006–2008 pooled data as a reference. Regardless of sex, the weighted percentage of adolescents with sexual experience who reported early sexual initiation increased in 2014–2016 with statistical significance in most cases. Moreover, the possibility of experiencing early sexual intercourse overtime was more prominent among girls than boys. While indifference to adolescent sexual behavior continues, more adolescents become involved in early sexual initiation. Socio-environmental considerations, such as the establishment of safe environments for adolescents’ sexual activity, along with systematized monitoring mechanisms, should be administered.
Corrosion Resistance Performance of Epoxy Coatings Incorporated with Unmilled Micro Aluminium Pigments
Authors: Abdus Samad Ubair , Alam Mohammad Asif , Seikh Asiful H. , Mohammed Jabair A. , Al-Zahrani Saeed M. , Sherif El-Sayed M.
Published: March 2023

The current work is in continuation of our previous work where we reported changes in the properties of epoxy coatings using two different types of hardener in different stoichiometric ratios. The best results-oriented coating stoichiometry was then taken in this research for further modification with the incorporation of 1, 2 and 3 wt.% micro aluminium (Al) pigments designed for coating carbon steel panels. After 7 d of curing, the coated panels were characterized using X-ray diffraction (XRD), (SEM) scanning electron microscopy, (TGA) thermogravimetric analysis, pendulum hardness, a scratch test and nano-indentation. Electrochemical tests were carried out for various exposure periods of time, i.e., 1 h, 7 d, 14 d, 21 d and 30 d, in a 3.5% sodium chloride (NaCl) solution. For the coatings, we found that the presence of 1% Al provided the highest corrosion resistance after exposure periods in the NaCl solution. We also found that prolonging the immersion time decreases the corrosion resistance after 7 d, but increasing the time of immersion to longer periods (14 d, 21 d and 30 d) enhances the corrosion resistance and reduces the degradation of the coatings.
Detection and Evaluation of Environmental Stress in Winter Wheat Using Remote and Proximal Sensing Methods and Vegetation Indices—A Review
Authors: Skendžić Sandra , Zovko Monika , Lešić Vinko , Pajač Živković Ivana , Lemić Darija
Published: March 2023

Climate change has a significant impact on winter wheat (Triticum aestivum L.) cultivation due to the occurrence of various environmental stress parameters. It destabilizes wheat production mainly through abiotic stresses (heat waves, drought, floods, frost, salinity, and nutrient deficiency) and improved conditions for pest and disease development and infestation as biotic parameters. The impact of these parameters can be reduced by timely and appropriate management measures such as irrigation, fertilization, or pesticide application. However, this requires the early diagnosis and quantification of the various stressors. Since they induce specific physiological responses in plant cells, structures, and tissues, environmental stress parameters can be monitored by different sensing methods, taking into account that these responses affect the signal in different regions of the electromagnetic spectrum (EM), especially visible (VIS), near infrared (NIR), and shortwave infrared (SWIR). This study reviews recent findings in the application of remote and proximal sensing methods for early detection and evaluation of abiotic and biotic stress parameters in crops, with an emphasis on winter wheat. The study first provides an overview of climate-change-induced stress parameters in winter wheat and their physiological responses. Second, the most promising non-invasive remote sensing methods are presented, such as airborne and satellite multispectral (VIS and NIR) and hyperspectral imaging, as well as proximal sensing methods using VNIR-SWIR spectroscopy. Third, data analysis methods using vegetation indices (VI), chemometrics, and various machine learning techniques are presented, as well as the main application areas of sensor-based analysis, namely, decision-making processes in precision agriculture.
Computer-Aided Diagnoses for Sore Throat Based on Dynamic Uncertain Causality Graph
Authors: Bu Xusong , Zhang Mingxia , Zhang Zhan , Zhang Qin
Published: March 2023

The causes of sore throat are complex. It can be caused by diseases of the pharynx, adjacent organs of the pharynx, or even systemic diseases. Therefore, a lack of medical knowledge and experience may cause misdiagnoses or missed diagnoses in sore throat diagnoses, especially for general practitioners in primary hospitals. This study aims to develop a computer-aided diagnostic system to assist clinicians in the differential diagnoses of sore throat. The computer-aided system is developed based on the Dynamic Uncertain Causality Graph (DUCG) theory. We cooperated with medical specialists to establish a sore throat DUCG model as the diagnostic knowledge base. The construction of the model integrates epidemiological data, knowledge, and clinical experience of medical specialists. The chain reasoning algorithm of the DUCG is used for the differential diagnoses of sore throat. The system can diagnose 27 sore throat-related diseases. The model builder initially tests it with 81 cases, and all cases are correctly diagnosed. Then the system is verified by the third-party hospital, and the diagnostic accuracy is 98%. Now, the system has been applied in hundreds of primary hospitals in Jiaozhou City, China, and the degree of recognition for doctors to the diagnostic results of the system is more than 99.9%. It is feasible to use DUCG for the differential diagnoses of sore throat, which can assist primary doctors in clinical diagnoses and the diagnostic results are acceptable to clinicians.
Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease
Authors: Chiriac Stefan , Sfarti Catalin Victor , Minea Horia , Stanciu Carol , Cojocariu Camelia , Singeap Ana-Maria , Girleanu Irina , Cuciureanu Tudor , Petrea Oana , Huiban Laura , Muzica Cristina Maria , Zenovia Sebastian , Nastasa Robert , Stafie Remus , Rotaru Adrian , Stratina Ermina , Trifan Anca
Published: March 2023

Inflammatory bowel diseases (IBD) represent a global phenomenon, with a continuously rising prevalence. The strategies concerning IBD management are progressing from clinical monitorization to a targeted approach, and current therapies strive to reduce microscopic mucosal inflammation and stimulate repair of the epithelial barrier function. Intestinal permeability has recently been receiving increased attention, as evidence suggests that it could be related to disease activity in IBD. However, most investigations do not successfully provide adequate information regarding the morphological integrity of the intestinal barrier. In this review, we discuss the advantages of confocal laser endomicroscopy (CLE), which allows in vivo visualization of histological abnormalities and targeted optical biopsies in the setting of IBD. Additionally, CLE has been used to assess vascular permeability and epithelial barrier function that could correlate with prolonged clinical remission, increased resection-free survival, and lower hospitalization rates. Moreover, the dynamic evaluation of the functional characteristics of the intestinal barrier presents an advantage over the endoscopic examination as it has the potential to select patients at risk of relapses. Along with mucosal healing, histological or transmural remission, the recovery of the intestinal barrier function emerges as a possible target that could be included in the future therapeutic strategies for IBD.
Anticholinergic Medication and Caries Status Predict Xerostomia under 65
Authors: Cheah Hui Ling , Gray Michael , Aboelmagd Shahenda , Barmak Abdul Basir , Arany Szilvia
Published: March 2023

The use of anticholinergic medications is increasing in younger ages, yet information about xerostomia, the most common anticholinergic side effect, is limited. This case–control retrospective study examines the relationship between anticholinergic medication-induced xerostomia and caries status among adults between 18 and 65 years of age. The study sample comprised 649 cases with xerostomia and 649 age- and gender-matched controls. The anticholinergic burden was estimated using the anticholinergic drug scale (ADS). Caries experience was recorded by calculating the Decayed, Missing, Filled Tooth (DMFT) index. Individuals with xerostomia had a higher mean DMFT index (16.02 ± 9.50), which corresponded with a higher level of anticholinergic exposure from medications (3.26 ± 2.81) compared to their age and gender-matched controls without xerostomia (13.83 + 8.83 and 1.89 ± 2.45, respectively). Logistic regression analysis verified the effects of DMFT, the total number of AC medications, and the ADS burden on xerostomia status. Comparing adults with or without xerostomia revealed statistical differences in several risk factors, such as smoking, diabetes, sleep apnea, and the utilization of anticholinergic medications. A personalized dental care plan should include the evaluation of the anticholinergic burden from medications regardless of the patient’s age to prevent increased caries severity.
Drone Elevation Control Based on Python-Unity Integrated Framework for Reinforcement Learning Applications
Authors: Abbass Mahmoud Abdelkader Bashery , Kang Hyun-Soo
Published: March 2023

Reinforcement learning (RL) applications require a huge effort to become established in real-world environments, due to the injury and break down risks during interactions between the RL agent and the environment, in the online training process. In addition, the RL platform tools (e.g., Python OpenAI’s Gym, Unity ML-Agents, PyBullet, DART, MoJoCo, RaiSim, Isaac, and AirSim), that are required to reduce the real-world challenges, suffer from drawbacks (e.g., the limited number of examples and applications, and difficulties in implementation of the RL algorithms, due to difficulties with the programing language). This paper presents an integrated RL framework, based on Python–Unity interaction, to demonstrate the ability to create a new RL platform tool, based on making a stable user datagram protocol (UDP) communication between the RL agent algorithm (developed using the Python programing language as a server), and the simulation environment (created using the Unity simulation software as a client). This Python–Unity integration process, increases the advantage of the overall RL platform (i.e., flexibility, scalability, and robustness), with the ability to create different environment specifications. The challenge of RL algorithms’ implementation and development is also achieved. The proposed framework is validated by applying two popular deep RL algorithms (i.e., Vanilla Policy Gradient (VPG) and Actor-Critic (A2C)), on an elevation control challenge for a quadcopter drone. The validation results for these experimental tests, prove the innovation of the proposed framework, to be used in RL applications, because both implemented algorithms achieve high stability, by achieving convergence to the required performance through the semi-online training process.
The Impact of COVID-19 Pandemic on Islamic and Conventional Banks’ Profitability
Authors: Shah Sayyed Sadaqat Hussain , Gherghina Ștefan Cristian , Dantas Rui Miguel , Rafaqat Saliha , Correia Anabela Batista , Mata Mário Nuno
Published: March 2023

The banking sector has a significant impact on a nation’s financial stability and economic development. As one of the fundamental components of the financial sector, banks offer services that are essential for the expansion of the markets. The stability of the financial system is significantly impacted by the efficiency of the banking sector. COVID-19 has had a tremendous effect on the economy. This pandemic cannot be disregarded, considering how widespread it has been and how many people it has affected globally. Both society and the global economy have undergone profound change. Hence, it is critical to ascertain how severely the outbreak has impacted the banking system. To assess the potential impact of pandemic, the current study examined conventional and Islamic banking. This study also investigates how COVID-19’s moderating effect influences the banking system. Financial statements from 10 conventional banks and 5 Islamic banks in Pakistan are the sources of this study’s sample data. COVID-19 is a moderator in this study. The empirical estimations by means of the fixed-effects approach suggests that the moderator has a large impact on bank profitability. In addition, COVID-19 appears to have a stronger influence on the Islamic banking system.
Electromyography Monitoring Systems in Rehabilitation: A Review of Clinical Applications, Wearable Devices and Signal Acquisition Methodologies
Authors: Al-Ayyad Muhammad , Owida Hamza Abu , De Fazio Roberto , Al-Naami Bassam , Visconti Paolo
Published: March 2023

Recently, there has been an evolution toward a science-supported medicine, which uses replicable results from comprehensive studies to assist clinical decision-making. Reliable techniques are required to improve the consistency and replicability of studies assessing the effectiveness of clinical guidelines, mostly in muscular and therapeutic healthcare. In scientific research, surface electromyography (sEMG) is prevalent but underutilized as a valuable tool for physical medicine and rehabilitation. Other electrophysiological signals (e.g., from electrocardiogram (ECG), electroencephalogram (EEG), and needle EMG) are regularly monitored by medical specialists; nevertheless, the sEMG technique has not yet been effectively implemented in practical medical settings. However, sEMG has considerable clinical promise in evaluating muscle condition and operation; nevertheless, precise data extraction requires the definition of the procedures for tracking and interpreting sEMG and understanding the fundamental biophysics. This review is centered around the application of sEMG in rehabilitation and health monitoring systems, evaluating their technical specifications, including wearability. At first, this study examines methods and systems for tele-rehabilitation applications (i.e., neuromuscular, post-stroke, and sports) based on detecting EMG signals. Then, the fundamentals of EMG signal processing techniques and architectures commonly used to acquire and elaborate EMG signals are discussed. Afterward, a comprehensive and updated survey of wearable devices for sEMG detection, both reported in the scientific literature and on the market, is provided, mainly applied in rehabilitation training and physiological tracking. Discussions and comparisons about the examined solutions are presented to emphasize how rehabilitation professionals can reap the aid of neurobiological detection systems and identify perspectives in this field. These analyses contribute to identifying the key requirements of the next generation of wearable or portable sEMG devices employed in the healthcare field.
Dynamic Optimal Power Flow of Active Distribution Network Based on LSOCR and Its Application Scenarios
Authors: Meng Weiqi , Song Dongran , Deng Xiaofei , Dong Mi , Yang Jian , Rizk-Allah Rizk M. , Snášel Václav
Published: March 2023

Optimal power flow (OPF) is a crucial aspect of distribution network planning and operation. Conventional heuristic algorithms fail to meet the system requirements for speed and accuracy, while linearized OPF approaches are inadequate for distribution networks with high R/X ratios. To address these issues and cater to multi-period scenarios, this study proposes a dynamic linearized second-order cone programming-based (SOCP) OPF model. The model is built by first establishing a dynamic OPF model based on linearized second-order conic relaxation (LSOCR-DOPF). The components of the active distribution network, such as renewable energy power generation units, energy storage units, on-load-tap-changers, static var compensators, and capacitor banks, are then separately modeled. The model is implemented in MATLAB and solved by YALMIP and GUROBI. Finally, three representative scenarios are used to evaluate the model accuracy and effectiveness. The results show that the proposed LSOCR-DOPF model can ensure calculation time within 3 min, voltage stability, and error control within 10−6 for all three applications. This method has strong practical value in the fields of active distribution network day-ahead dispatch, accurate modeling of ZIP load, and real-time operation.
A Sustainable Forage-Grass-Power Fuel Cell Solution for Edge-Computing Wireless Sensing Processing in Agriculture 4.0 Applications
Authors: Estrada-López Johan J. , Vázquez-Castillo Javier , Castillo-Atoche Andrea , Osorio-de-la-Rosa Edith , Heredia-Lozano Julio , Castillo-Atoche Alejandro
Published: March 2023

Intelligent sensing systems based on the edge-computing paradigm are essential for the implementation of Internet of Things (IoT) and Agriculture 4.0 applications. The development of edge-computing wireless sensing systems is required to improve the sensor’s accuracy in soil and data interpretation. Therefore, measuring and processing data at the edge, rather than sending it back to a data center or the cloud, is still an important issue in wireless sensor networks (WSNs). The challenge under this paradigm is to achieve a sustainable operation of the wireless sensing system powered with alternative renewable energy sources, such as plant microbial fuel cells (PMFCs). Consequently, the motivation of this study is to develop a sustainable forage-grass-power fuel cell solution to power an IoT Long-Range (LoRa) network for soil monitoring. The stenotaphrum secundatum grass plant is used as a microbial fuel cell proof of concept, implemented in a 0.015 m3-chamber with carbon plates as electrodes. The BQ25570 integrated circuit is employed to harvest the energy in a 4 F supercapacitor, which achieves a maximum generation capacity of 1.8 mW. The low-cost pH SEN0169 and the SHT10 temperature and humidity sensors are deployed to analyze the soil parameters. Following the edge-computing paradigm, the inverse problem methodology fused with a system identification solution is conducted, correcting the sensor errors due to non-linear hysteresis responses. An energy power management strategy is also programmed in the MSP430FR5994 microcontroller unit, achieving average power consumption of 1.51 mW, ∼19% less than the energy generated by the forage-grass-power fuel cell. Experimental results also demonstrate the energy sustainability capacity achieving a total of 18 consecutive transmissions with the LoRa network without the system’s shutting down.
Conformable Inflatable Wings Woven Using a Jacquard Technique
Authors: Breuer Joep , Luchsinger Rolf , Schmehl Roland
Published: March 2023

Inflatable wings are of interest for applications where low weight, compact transport volume, and easy set-up are important. Examples are unmanned aerial vehicles with inflatable wings, paragliders and softkites for sport or airborne wind-energy applications. In this paper, a new method of designing and fabricating conformable inflatable wings by Jacquard three-dimensional weaving is presented. Depending on the weaving pattern, plane-parallel, tapered, or even curved structures can be produced. An analytical framework was developed to determine the shapes of pressurized structures produced by Jacquard weaving. Based on this theory, several design patterns suitable for inflatable wings are proposed. It is shown that the structural efficiency of the woven structure is identical to the structural efficiency of a cylinder. To validate the concept, different wing prototypes were built with the methods used for the mass production of airbags. The new method allows for the cost-efficient fabrication of inflatable structures, pressure vessels, and liquid containers with applications in the automotive, aerospace, and leisure industries.
Rate Decline of Acid Fracturing Stimulated Well in Bi-Zone Composite Carbonate Gas Reservoirs
Authors: Li Li , Tian Wei , Shi Jiajia , Tan Xiaohua
Published: March 2023

This paper develops a model of the multi-wing finite-conductivity fractures considering stress sensitivity for low-permeability bi-zone composite gas reservoirs. A new semi-analytical solution in the Laplace domain is presented. The main solution includes the theory of source function, Laplace integral transformation, perturbation technique, and Stehfest numerical inversion. Wellbore pressure is obtained by coupling solutions of reservoirs and fractures. The results showed that the pressure and derivative curves generated by this model include a bi-linear flow stage. The model was validated by comparing its results with Wang’s results and the commercial well-test simulator; the results showed excellent agreement. This model illustrated the seepage characteristic of acid fracturing stimulated wells during refracturing treatment and how they are influenced by reservoir and hydraulic fractures parameters (asymmetrical factor and fractures distribution, etc.). The model is suitable to solve the solution of arbitrary-angle hydraulic fracture in refracturing and helpful to understand the transient production rate characteristic of the multi-wing fracturing well.
Primary Growth Behavior of Sulfur Particles through the Throttle Valve in the Transmission System of High Sulfur Content Natural Gas
Authors: Liu Gang , Chen Duo , Li Bo , Li Changjun
Published: March 2023

The deposition of sulfur particles in gathering and transportation pipeline system can cause serious safety problems and economic losses. When the high sulfur content natural gas (HSCNG) flows through the throttle valve of the gathering and transportation system, it will cause the supersaturation of elemental sulfur in the gas phase, and then the sulfur crystal nuclei and sulfur particles will appear in the pipeline system. Studying the initial growth behavior of sulfur crystal nuclei and sulfur particles can lay a necessary prerequisite for the accurate prediction of sulfur particle deposition in high sulfur content natural gas gathering and transportation (HSCNGGT) pipelines. Based on the homogeneous nucleation theory in crystallization kinetics, a mathematical model of elemental sulfur nucleation was established. Taking the throttling condition in the process of HSCNGGT as an example, the effects of temperature, pressure and H2S concentration in HSCNG on the critical nucleation radius and nucleation rate of elemental sulfur were explored. The results show that: (1) after the supersaturation of elemental sulfur, sulfur crystal nuclei with nanoscale radius will be precipitated. The temperature and pressure after throttling have great influence on the nucleation radius, and the influence of H2S concentration on the nucleation radius is more complex. (2) The temperature, pressure and H2S concentration after throttling also have great influence on the nucleation rate. By solving the growth kinetics model of sulfur particles based on Brownian condensation, it is found that the nano-sized sulfur crystal nuclei can grow into micron-sized sulfur particles in a very short time.
Enhancing the Energy Efficiency—COP of the Heat Pump Heating System by Energy Optimization and a Case Study
Authors: Nyers Arpad , Nyers Jozsef
Published: March 2023

This article deals with the degrees of freedom and possible optimums, specifically with the energy optimums of the heat pump heating system. The authors developed an multi objective optimization procedure that allows for the determination of the optimal motor power for the circulation and well pumps in order to achieve the maximum COP. Upon selecting the type and size of the water-to-water heat pump, based on the heating demand of the buildings, the proper power of the circulation and well pumps must be determined. There are several procedures used for determining the pump’s power. However, none of those methods ensures the optimum power, i.e., the maximum coefficient of performance, COP of the heating system. In this study, a multi objective analytical-numerical dimensioning procedure was developed for the determination of the optimal mass flow rate of warm and well water. Based on the flow rate values, the optimum power of the circulation and well pumps can be calculated. Due to the wide scope of the topic, the application of the optimization procedure is presented in a case study, but only for determining the optimum power of the circulation pump. The validity of the procedure was confirmed by measurements. The results obtained with the optimization showed that through the energy optimization of the circulation pump power, the COP of the system increased by 5.34%.
Dynamic User Resource Allocation for Downlink Multicarrier NOMA with an Actor–Critic Method
Authors: Wang Xinshui , Meng Ke , Wang Xu , Liu Zhibin , Ma Yuefeng
Published: March 2023

Future wireless communication systems require higher performance requirements. Based on this, we study the combinatorial optimization problem of power allocation and dynamic user pairing in a downlink multicarrier non-orthogonal multiple-access (NOMA) system scenario, aiming at maximizing the user sum rate of the overall system. Due to the complex coupling of variables, it is difficult and time-consuming to obtain an optimal solution, making engineering impractical. To circumvent the difficulties and obtain a sub-optimal solution, we decompose this optimization problem into two sub-problems. First, a closed-form expression for the optimal power allocation scheme is obtained for a given subchannel allocation. Then, we provide the optimal user-pairing scheme using the actor–critic (AC) algorithm. As a promising approach to solving the exhaustive problem, deep-reinforcement learning (DRL) possesses higher learning ability and better self-adaptive capability than traditional optimization methods. Simulation results have demonstrated that our method has significant advantages over traditional methods and other deep-learning algorithms, and effectively improves the communication performance of NOMA transmission to some extent.