bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of IgG Response Profile in SARS-CoV-2 Patients Using a Multiplex Serological Assay
Authors:   Department of Virology, Amiens University Medical Center, Amiens, France, E Brochot , V Souplet ,   nnobiochips, 70 rue du Dr Yersin, 59120 Loos, France, P Follet ,   nnobiochips, 70 rue du Dr Yersin, 59120 Loos, France, P Ponthieu ,   nnobiochips, 70 rue du Dr Yersin, 59120 Loos, France, C Olivier ,   nnobiochips, 70 rue du Dr Yersin, 59120 Loos, France, G Even ,   GD Biotech, 3595 Route de Tournai, 59501 Douai, France, C Audebert ,   GD Biotech, 3595 Route de Tournai, 59501 Douai, France, R Malbec ,   GD Biotech, 3595 Route de Tournai, 59501 Douai, France
Published: June 2021

Background: Beyond the diagnosis of SARS-CoV-2 infection, tools delivering a global picture of the patients’ humoral response may be of interest for the comprehension of the disease severity and the assessment of the patients’ protection for vaccination strategy. Objectives: Here we use a commercial multiplex serological immunoassay CoViDiag®, based on an array of five different antigens of the virus (the Nucleocapsid, the Spike 1 and Spike 2 subunits, and the RBD and NTD domains of the Spike), to investigate the profile of the IgG humoral response for patients with recent SARS-CoV-2 infection depending on the disease severity outcome, or the time post-PCR. Results: No cross-reaction was observed with the four other seasonal coronaviruses (100% specificity, 0/28). 100% (20/20) of the hospitalized patients PCR-positive to SARS-CoV-2 presented detectable levels of IgGs. 14 days post-PCR diagnosis, 92.3% of the patients, PCR-positive, that did not required hospitalization are presenting IgG (36/39). Interestingly for CoViDiag-positive samples, detectable levels of anti-RBD were found mainly in hospitalized patients (85%, 17/20), while the presence of anti-S1 (60.9%, 28/46) combined with the absence of anti-RBD (6.5%, 3/46) was more characteristic of nonhospitalized patients. Screening campaign group lacked both anti-S1 (18.2%, 4/22) and anti-RBD (4.5%, 1/22). Conclusion: The CoViDiag® IgG assay could be used to evaluate patients’ immunization and improve their management.
The Role of the Polish Interdepartmental Commission for the Maximum Admissible Concentrations and Intensities for Agents Harmful to Health in the Working Environment in the Development of Safe Working Conditions
Authors:   Department of Chemical, Aerosol and Biological Hazards, Centralny Instytut Ochrony Pracy-Panstwowy Instytut Badawczy/Central Institute for Labour Protection-National Research Institute, Warszawa, Poland, J Skowron , L Zapór ,   Central Institute for Labour Protection-National Research Institute, Warsaw, Poland, K Miranowicz-Dzierzawska ,   Central Institute for Labour Protection-National Research Institute, Warsaw, Poland
Published: June 2021

The article discusses the principles of determining the maximum admissible concentration and intensity values for harmful agents present at workplaces as the basic criteria for ensuring safe and hygienic working conditions in Poland and in the European Union. The role of the Interdepartmental Commission for the Maximum Admissible Concentrations and Intensities of Agents Harmful to Health in the Working Environment is presented in this process. The attention was drawn to the relationship between the occupational health and safety legislation and the EC regulations on chemicals, which together provide both employers and the Member States with the necessary data and instruments to work safely with chemicals and to be able to take appropriate actions and risk management measures.
Assessment of COPD Overdiagnosis as an Important Factor in COPD Readmission
Authors:   Hospitalist Medicine, Elkhart General Hospital, Beacon Health System, Elkhart, IN, USA, S Pandey , S Ojha ,   Pulmonary Medicine, Bellin Hospital, Green Bay, WI, USA
Published: June 2021

Introduction: The Hospital Readmission Reduction Program (HRRP) was established in 2012 to improve health care by linking payment to the quality of hospital care. Readmission is considered a hospital care quality measure. Under the program, hospitals are penalized for Chronic Obstructive Pulmonary Disease (COPD) readmission, which incentivizes improved care to avoid financial penalties. The effect of COPD overdiagnosis on COPD readmission has not been studied. Objective: The study aims to assess the effect of COPD overdiagnosis in outpatient and inpatient settings on hospital COPD readmissions. Methods: We conducted a retrospective study and examined outpatient and inpatient settings for COPD overdiagnosis. In the outpatient setting, we collected all COPD referrals to our clinic and reviewed charts to determine if those patients had COPD or an alternate diagnosis after our workup. We also studied 3-year inpatient data from January 2015 to March 2018 on hospital readmissions and extracted COPD readmissions. For patients seen by a pulmonary provider in our clinic, we studied patients’ pulmonary function test/ spirometry results and charts and determined if they had a true COPD diagnosis or an overdiagnosis. We also assessed the effect of COPD overdiagnosis on inflation of COPD readmission numbers. Results: Of patients referred to our clinic, 46% did not have COPD on our workup. Among inpatients, our results revealed that preventing COPD overdiagnosis could have reduced admissions attributable to COPD by 22.6%. Conclusion: Correct diagnosis using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria is an inexpensive way for hospitals to avoid readmission penalties.
Tympanic Membrane Perforation and COVID-19
Authors:   ENT and Head & Neck Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran, FDM Firouzabadi , MD Firouzabadi ,   ENT and Head & Neck Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran, F Moosaie ,   ENT and Head & Neck Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran, S Rafiee ,   ENT and Head & Neck Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran, M Roomiani ,   ENT and Head & Neck Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran, H Jahandideh ,   ENT and Head & Neck Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran, N Yoosefi ,   Department of Cellular and Physiological Sciences, Faculty of medicine, University of British Columbia, Canada, S Ramezanpour ,   Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA, S Babaniamansour ,   School of Medicine, Islamic Azad University Tehran Faculty of Medicine, Tehran, Iran
Published: June 2021

Background: World Health Organization considers the outbreak of coronavirus disease 2019 (COVID-19) as a global pandemic. The perforation of Tympanic Membrane (TMP), followed by remission of COVID-19, can be an uncommon presentation. Case Report: This report is an unusual case of COVID-19 in an elderly woman who did not have any past medical history. She was admitted to the hospital with an uncommon, but serious presentation of TMP after one week of remission from COVID-19 infection. Otoscopy of ear revealed clear external auditory canal and central perforation in the pars tensa with regular margins occupying the posteroinferior quadrant. Computed tomography scan (axial view) with thin cuts of the temporal bone revealed well pneumatized mastoid regions without any density or secretion and normal middle ears without any density or secretion. After 2 months, tympanoplasty without mastoidectomy was performed, the patient recovered fully, the TMP was healed, and an audiogram performed 2 months later was found to be normal. Conclusion: This case highlighted the importance of attention to uncommon presentations, such as otalgia, and a sensation of fullness in the ear that can be subsequent to bacterial superinfection after Covid-19 infection.
Surgical Shunt Procedures in Childhood Portal Hypertension: A Review Article
Authors:   Professor of Pediatric Surgery, Saglik Bilimleri University, Izmir Faculty of Medicine, Department of Pediatric Surgery, Izmir Tepecik Health and Research Center, Turkey, Erikci Volkan Sarper
Published: June 2021

Normal portal pressure is between 0 and 10 mmHg and the pressure in the portal vein is slightly higher than that of the pressure in the inferior vena cava [1]. Portal Hypertension (PH) is usually defined as either a hepatice venous pressure gradient greater than 5mmHg or hepatic venous wedge pressure greater than 10mmHg [2]. It is usually encountered as a complication arising from chronic liver disease and cirrhosis. Common presentation of PH in children include catastrophic variceal hemorrhage usually from esophagus. Other common clinical features of PH include splenomegaly, hypersplenism, ascites, encephalopathy, and hepatopulmonary syndrome and portopulmonary hypertension. It has been reported that up to 15% of children with PH ultimately require shunt surgery [2]. Traditionally shunt surgery was a treatment option for children in whom control of variceal bleeding failed however; it was associated with relatively high rate of anastomotic stricture or thrombosis [1]. Nowadays it has also been reported that as the experience in vascular and transplant surgery together with microsurgical techniques have improved good success rates can be achieved even in small children [1]. In this review article, it is aimed to review the surgical treatment options in children with PH with special regard to shunt procedures under the light of relevant literature.
Prevalence of Stress Urinary Incontinence in Women from a Rural Community in the Brazilian Amazon
Authors:   Gynecology-Obstetrics, Federal University of Amapá, Brazil, AD Do Rego , ACM Morais ,   Medicine Student of Federal University of Amapá, Brazil, JT Molisani ,   Medicine Student of Federal University of Amapá, Brazil, LGA Nascimento ,   Medicine Student of Federal University of Amapá, Brazil
Published: June 2021

Introduction: Stress urinary incontinence affects a significant number of women and causes great loss of Quality of Life (QoL). Its prevalence varies from 15 to 41.5%. Objective: To assess the prevalence of Stress Urinary Incontinence (SUI) in women living in a rural community in Amapá, the main risk factors and quality of life assessment using a standardized questionnaire. Methodology: A screening questionnaire was applied to 235 women residing in Igarapé da Fortaleza, in the city of Macapá, in 2015. Patients with SUI complaints were submitted to the King’s Health Questionnaire (KHQ) questionnaire. For statistical processing, BioEstat software version 5.3 was used. Results: The prevalence of SUI was 28.9% (68 women). A significant age difference was found between women with SUI (44.2) and without SUI (37.9 ± 12.5 years). Childbirth, birth interval, smoking and Body Mass Index (BMI) showed to be statistically significant differences between groups. Variables such as number of deliveries, birth weight, menopause, education and race did not express a real difference. Conclusion: The prevalence of SUI was 28.9%. There was a significant difference in the group with SUI in terms of age, smoking, parity, interval between births and BMI. In assessing QoL in patients with SUI using KHQ, we found the worst results in general health perception, impact of incontinence, personal relationships, sleep/mood and severity of symptoms.
Giant Testicular Cancer: Clinical Picture
Authors:   Urology Division, CHU Hassan 2, Fez, Morocco, M Mohammed , ZOJ Dieudonne ,   Urology Division, CHU Hassan 2, Fez, Morocco, M Jaafar ,   Urology Division, CHU Hassan 2, Fez, Morocco, R Youness ,   Urology Division, CHU Hassan 2, Fez, Morocco, E Soufiane ,   Urology Division, CHU Hassan 2, Fez, Morocco, A Mustapha ,   Urology Division, CHU Hassan 2, Fez, Morocco, M Soufiane ,   Urology Division, CHU Hassan 2, Fez, Morocco, TM Fadl ,   Urology Division, CHU Hassan 2, Fez, Morocco, E-A Jalal Eddine ,   Urology Division, CHU Hassan 2, Fez, Morocco, EM Jamal ,   Urology Division, CHU Hassan 2, Fez, Morocco, FM Hassan ,   Urology Division, CHU Hassan 2, Fez, Morocco
Published: June 2021

Testicular tumour is the most malignant cancer in young males 15 to 34 years of age. Its accounts for 1% of all male cancer and 5% of urological malignancy [1]. The management of this type of cancer is radical inguinal orchiectomy which is the gold standard for the diagnosis and initial management of a suspected testicular cancer. Trans -scrotal orchiectomy is discouraged because scrotal violation is associated with higher rates of local recurrence and altered pathways of metastatic dissemination [2]. We report a young patient 23 years old. History: Chronic smoking, cannabis. Admitted for large bursa evolving for 14 months. The history of the disease dates back to 14 months by the gradual increase in the volume of the bursa with an alteration of the general status with a weight loss estimated at 10kgs. Clinical examination showed: right hemi-scrotum increased in volume with a hard consistency with a left testicle repressed in extreme lateral and some inflammatory lesions. Right testis was not palpable with a cord repulsed and glued to the inguinal orifice. The ultrasound of the scrotal content showed: large right testis hypervascularized with moderate anterior cloisonnae hydrocele, bilateral testicular microlithiasis. Tumor markers: Lactate Dehydrogenase (LDH) 229IU, beta-Human Chorionic Gonadotropin (beta-hCG) 29.73mUI/ ml, Alpha-Foetoprotein (AFP) 400IU/ml. Patient benefited from a complete pre-operative assessment that did not object to any abnormality. Programmed for a right inguinal orchiectomy and reduction scrotoplasty (Figure 1).
Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure
Authors: Fedosieieva O.V.
Published: June 2021

During the individual development and exposure to infectious agents of the organism, the structural components of the thyroid gland can change significantly. In modern research, great importance is attached to the study of mechanisms for maintaining morphological homeostasis of the thyroid gland and ideas about its structural and functional restructuring in response to the body's immune system to various infections. The morpho-functional features of the thyroid gland of newborn animals after prenatal action of thyroid-nonspecific antigen (staphylococcal toxoid) have been experimentally established. In antigen-premiumed rats, the timing of folliculogenesis changes, as well as the size, distribution and immunohistochemical expression of antibodies to thyroglobulin, the functional state of thyrocytes and follicles compared to normal. The detected immuno­histochemical changes indicate signs of morpho-functional immaturity of the organ with hypoactivity elements.
Determining hemodynamic significance of patent ductus arteriosus using echocardiographic data prognostic tables
Authors: Kulikova D.A. , Safonova I.N. , Chumak L.I. , Poddubnaya I.N. , Protsenko O.S. , Dotsenko D.G.
Published: June 2021

The paper presents an analysis of echocardiographic data of patients with PDA having different hemodynamic significance. Presently, the concept of “degree of hemodynamic significance” remains controversial. Criteria for determining the hemodynamic significance of PDA in term infants are not described. In our work, we used a classification of three degrees of hemodynamic significance: non-hemodynamically significant PDA – insignificant, moderately hemodynamically significant – moderately significant and large PDA – hemodynamically significant PDA. Aim – to work out an algorithm for determining the degree of PDA hemodynamic significance for prediction of its further development. The study involved children under 18 years old (80% of them ‒ children under 3 years old) who were examined in the cardiac surgery department of the SI “IGUS n.a.V.T. Zaytsev NAMS of Ukraine” during 2013-2017 yy. Gestational age (from 37 weeks), the presence of left to right PDA shunt, absence of a ASD shunt and other congenital heart defects served as enrollment criteria for the trial. Two prognostic tables were formed with the main criteria for determining hemodynamic significance of PDA by the sum of the signs according to gradations (insignificant, moderately significant and hemodynamically significant) as an outcome of the trial. Based on the determination of the main and additional criteria of hemodynamic significance and the strength of their influence, a diagnostic algorithm is formed for a patient with PDA with the possibility of predicting a further clinical scenario. For determination of hemodynamic significance, an increase in pulmonary gradient with an information index of 1.135 and a prognostic factor of +5.90/-1.75 were dominant, while the left ventricular dilatation located from the A4C with an informational index of 1.020 and a prognostic coefficient of +3.69/-2.50 dominated in determining the degree of hemodynamic significance in the presence of secondary changes. The proposed mechanism for determining the level of hemodynamic significance of PDA for children with borderline changes will predict more precisely the development of the disease, determine the patient’s observation tactics and regulate the decision-making process of surgical intervention.
The impact of summer holidays on the physical development of school-age children
Authors: Danylenko H.M. , Cherniakova G.M. , Merkulova T.V. , Avdiievska O.H.
Published: June 2021

The aim of the work was to investigate how gender, age and type of activity in summer affects the indicators of physical development (PD) of children. 1054 students (493 boys and 561 girls) aged 7-16 years took part in the study. The PD of children was studied by assessing somatometric and physiometric indi­cators. To assess the impact of the type of activity, a thematic questionnaire "Summer" was used. It was found that the gender and age of children had a significant effect on PD indicators in the summer. The most intense increase in body length oc­curred at the age of 7-12 years, body weight - in 10-14-year-olds, and up to 16 years grouth of two parameters gradually slo­wed down. From the age of 10, children showed a positive increase in lung capacity (LC). In 15-year-old adolescents, a de­c­rease in both indicators (ChC and LC) was found. It was found that 62% of children carried out educational activities in the summer, 24% of those were engaged in business activities, almost 40% of students were participants in hiking trips and 23% of children attended a children's health camp. The chosen type of activity in the summer influenced the indicators of the pu­pils' PD as follows: educational activities were accompanied by a decrease in body length and strength of the left arm, busi­ness activity, hiking trips and staying in a health camp were accompanied by an increased weight gain and an increase in LC.
Bladder cfncer: features of epidemiology and indicators of specialized care delivery
Authors: Saidakova N.O. , Yatsina О.І. , Grodzinsky V.I. , Stus V.P. , Polion M.Y. , Shiloh V.M. , Коnonova G.E.
Published: June 2021

The work is based on the materials of official statistical reporting, the analysis of which was carried out for 10 years, divided into two five-year periods (2009-2013 and 2014-2018). Absolute and intensive rates of morbidity and distribution of bladder cancer of the adult population of Ukraine in the regional aspect, taking into account sex were studied, the basic indicators of the prevalence of pathology were analyzed as well. The revealed unfavorable situation is characterized by a steady increase in morbidity and prevalence at a slower pace during 2014-2018. It is noteworthy the high level of morbidity in men, which is growing against the background of its stabilization among women. At the same time, there was noted the tendency in the reduced number of newly diagnosed patients during professional examinations (in 2018-16.9% against 18.0% in 2014) with diagnosis at stages I-II (72.2% vs. 74.79%), wherein every fifth has stage III-IV. With a tendency to increase in the number of registered patients ≥ 5 years (59.1% vs. 56.5%), the death rate did not change significantly within a year from the time of diagnosis (14.7% vs. 15.6%, respectively). In the structure of specialized care, (65% are patients with the first diagnosis), surgical method accounted for 37-40% by years, the combined was second (up to 20% by years), then radiation and chemotherapy, which together did not exceed 5.0%. Areas with high or low relative rates in relation to the average Ukrainian indicators for all parameters studied were identified. In the presence of regional differences, there is a need for in-depth studies of the state of the issue, including the quality and organization of care.
Attitude of health care workers in the field of mental health to their health
Authors: Chorna V.V. , Makhniuk V.M. , Khliestova S.S. , Gumeniuk N.I. , Chaika H.V.
Published: June 2021

The article presents the results of theoretical and experimental studies of the degrees of value-motivational, cognitive, emotional, and behavioral components in health care workers of psychiatric health care facilities concerning their health. The degree of risk and value of the personal hygiene of health care workers is determined. The main components and factors that affect the attitude to personal health are revealed. The awareness of the own emotional and cognitive experiences by the medical staff of psychiatric hospitals regarding the preservation and strengthening of their hygiene is analyzed. According to research on the value-motivational component of the medical staff of psychiatric health care concerning the place of personal health in the hierarchy of values in life, it was found that own health is on the second place – 15.2% males, nursing staff (NS), 15.1% females, are psychiatrists and women NS, 14.8% are men psychiatrists. In case of a deterioration of own health both women (35,6%), and men (35,5%) psychiatrists are engaged in self-treatment, the similar tendency is among NS – women NS – 31,3%, men NS – 31, 5%), in 25.8% of cases female psychiatrists and in 23.1% of men NS do not pay attention to the disease at all, which leads to occupational diseases and chronic diseases. At the same time, occupational diseases among doctors and NS do not exceed 10% of the total number of occupational diseases in Ukraine due to self-medication and early treatment. Therefore, the statistics of occupational diseases of health workers in that field are underestimated compared to the actual ones.
Assessment of the Quality of Life of Oncological Patients Following Hysterovariectomy Associated with Thrombotic Complications
Authors:   I. Horbachevsky Ternopil National Medical University. 1, Maydan Voli, Ternopil 46002, Ukraine, Bodnar P. Ya.
Published: June 2021

Oncological treatment for post-operative patients is aimed to improve their symptomatic course and life prognosis. However, the subjection of a woman following radical intervention in her reproductive system has a devastating effect on the quality of life in this cohort of patients. Quality of life is one of the modern criteria for assessing the effectiveness of health care. The main tool for measuring quality of life is the standardized questionnaires produced by psychometric methods. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire was used to assess the quality of life of women with cancer with post-operative thrombotic complications. The purpose of the study was to assess the indicators dynamics of the quality of life in oncological patients before and after a hysterovariectomy associated with thrombotic complications. Materials and methods. In accordance with the purpose of the study, a comprehensive examination of 34 women with oncological diseases of the uterus and appendages with postoperative deep vein thrombosis, who were in hospital, was done. The average age of patients was 51.4 士 3.5. All patients underwent hysterovariectomy. The control group consisted of 30 healthy women. The set of diagnostic and therapeutic measures included a thorough clinical examination with anamnesis, features of menstrual and reproductive functions, transvaginal ultrasound scanning, hysteroscopy and histological examination of macrodrugs removed during surgery. The groups were compared by age, volume of surgery and comorbidities. Results and discussion. Analysis of the initial results of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire in oncological patients showed a low statistically significant score in all its scales compared to practically healthy women (p <0.05). In the group of patients with post-operative thrombotic complications, after a hysterovariectomy, there was an evident decrease by 46.5% in physical activity compared to the initial data (p <0.05). In the context of therapy, there has been a decrease in social contacts and in the level of communication due to physical and emotional limitations (p <0.05). The decline in quality of life was associated with an increase in sexual dysfunction in 100% of cases. Conclusion. The assessment of indicators of quality of life in patients with malignant neoplasia of the gynaecological sphere must be monitored before and after rapid treatment to determine the necessary social-medical algorithm of actions to adapt such patients during the rehabilitation period
The Role of Molecular Genetic Translocations in the Initial Response to the Treatment under the ALLIC BFM 2009 Program in Children Patients with Acute Lymphoblastic Leukemia
Authors:   Lviv Danylo Halytskyi National Medical University. 69, Pekarskaya St., Lviv 79010, Ukraine, Vynnytska O. A. , Dorosh O. I. , Dubey L. Ya. , Dubey N. V.
Published: June 2021

The correlation analysis between the number of blast cells in bone marrow and peripheral blood was performed, and the dependence of blast percentage on the presence of molecular genetic translocations (AF4/MLL, BCR/ABL1, TEL/AML, E2A/PBX1) in patients with acute lymphoblastic leukemia (ALL) under the conditions of ALLIC-BFM 2009 cytostatic therapy was researched. The purpose of the study was to establish a relationship between the number of blast cells in bone marrow and peripheral blood depending on the presence of molecular genetic translocations for early detection of induction treatment by ALLIC BFM 2009. Materials and methods. The survey group consisted of 105 children aged 12 months to 16 years (median age was 6 years). Among those surveyed were 62 boys (59.0%) and 43 girls (41.0%). All patients were diagnosed with acute lymphoblastic leukemia. Results and discussion. Correlation analysis revealed a high degree of correlation between the number of blast cells in the bone marrow and peripheral blood, as the correlation coefficient (r) is 0.87. It is shown that the increase in the number of blast cells depends on the presence of chromosomal translocations. The highest number of blasts was observed in patients with BCR/ABL1 and E2A/PBX1 translocations, in whom the content of blasts in bone marrow was 97 and 96%, respectively, and in peripheral blood - 67 and 73%, respectively. It was found that treatment under the ALLIC BFM 2009 program leads to a decrease in the number of blast cells in the bone marrow and blood with minimal values on the 33rd day of treatment. It has been shown that the highest levels of blast cells during chemotherapy are observed in patients with chromosomal translocations BCR/ABL1 and E2A/PBX1. In patients with AF4/MLL translocation, the efficacy of therapy was the highest because no blast cells in the bone marrow were visualized on day 33 of treatment. The study of the primary response of patients with acute lymphoblastic leukemia to induction treatment according to the ALLIC BFM 2009 program revealed the dependence of the level of blast cells of bone marrow and blood on the type of chromosomal aberration. Patients with BCR/ABL1 and E2A/PBX1 have the highest resistance to chemotherapy with molecular genetic translocations, and patients with AF4/MLL and TEL/AML have the lowest resistance, as evidenced by the presence and absence of blast cells in the peripheral blood, respectively. Conclusion. Establishing the relationship between cytogenetic and molecular genetic features of the tumour clone will help determine the degree of malignancy of the process, as well as the risk group for the course of the disease. Determining the dependence of acute leukemia on molecular genetic translocations will make it possible to further modify the treatment program
Forecasting of Non-Carcinogenic Risk for Population Health from Manufacturing of Mechanical Processing of Secondary Polymers
Authors:   Ivano-Frankivsk National Medical University. 2, Halytska St., Ivano-Frankivsk 76019, Ukraine, Malyshevska O. S.
Published: June 2021

The most hygienically safe process of recycling polymers is mechanical recycling, which does not cause the destruction of polymers, products of which dangerously affect all components of the environment and man. The purpose of the study is to predict the non-carcinogenic risk to public health from the production of mechanical processing of secondary polymers, depending on the presence or absence of the stage of mechanical activation in the processing process. Materials and methods: sanitary-epidemiological examination; risk assessment of dangerous factors for public health; instrumental assessment methods; statistical processing of results – determination of arithmetic mean values, standard error, quadratic deviation. Results and discussion. It is established that the total indicators of air pollution by polymer dust, nitrogen dioxide and carbon monoxide do not exceed the permissible level of pollution, and the degree of danger of this category of production is assessed as safe. Analysis of the obtained values of hazard coefficients of chemicals for the production of mechanical processing of secondary polymer raw materials without the stage of mechanical activation showed that the risk level for the maximum concentration of polymer dust and nitrogen dioxin at a distance of 25 m is assessed as alarming. The hazard factor for the maximum concentration of carbon monoxide at all distances studied did not exceed the permissible limits. For the production of mechanical processing of secondary polymer raw materials with the stage of mechanical activation, the level of risk for any of the test substances and at all distances studied did not exceed the allowable. Conclusion. Indices of danger of impact on individual organs and systems of the body (respiratory system, central nervous system, cardiovascular system, blood, eyes) of the investigated substances (polymer dust, nitrogen dioxide, carbon monoxide) at a distance of 50 m from the processing of secondary polymer raw materials without stages of mechanical activation are admissible, and for production with a stage of mechanical activation – minimum. It is established that according to the indicators of non-carcinogenic risk, sanitary-protection zone of production facilities for mechanical processing of secondary polymer raw materials without the stage of mechanical activation cannot be less than 50 m, and with the stage of mechanical activation can be reduced to 25 m
Rationale For a Regional Monitoring Program of Atmospheric Air Quality in the Dnepropetrovsk Region
Authors:   Dnipro State Medical University. 2,Soborna Sqr., Dnipro 49000, Ukraine, Stepanov S. V. , Rublevska N. I.
Published: June 2021

The air quality monitoring system in industrial cities is one of the systems for responding to risk factors in the public health system. The purpose of the study is, on the basis of a hygienic assessment of carcinogenic and non-carcinogenic risks from exposure to specific pollutants in the cities of Dnipro, Kamenskoye, Kryvyi Rih, to substantiate a program for regional monitoring of atmospheric air quality. Materials and methods. To achieve this goal, the results of air quality studies in the largest industrial cities of the Dnipropetrovsk region – Dnipro, Kryvyi Rih and Kamenskoe for the period 2005-2019 were analyzed in terms of phenol, formaldehyde, benzene, xylene and toluene, and carcinogenic and non-carcinogenic risks to public health were calculated in these cities. Results and discussion. According to the results of the study, individual carcinogenic risks in all three cities in terms of formaldehyde are medium, and in terms of benzene are high. The population carcinogenic risk ranges from 200-269 additional cases of cancer from exposure to formaldehyde and 3727-4426 additional cases of cancer from chronic inhalation exposure to benzene. The calculation of non-carcinogenic risks identified the priority specific air pollutants in the cities under study, as well as the main target organs. So the main systems that are influenced by the action of the studied chemicals are the central nervous system, the general development of the body and the blood system. Based on the risk assessment, it was established that it is necessary to include the Kamenskoye metro station for regional monitoring. It is necessary to include all pollutants from List A to the minimum list of investigated chemicals, and for the city of Dnipro and Kamenskoye it is additionally necessary to carry out studies of phenol, formaldehyde and toluene and in the city of Kryvyi Rih – formaldehyde and toluene. The mechanism of data processing and interaction between the subjects of monitoring has been substantiated for the timely identification of risks and the development of necessary preventive measures for risk management. Conclusion. It was found that carcinogenic and non-carcinogenic risks in industrial cities of the Dnipropetrovsk region are not acceptable. The existing monitoring system does not fully comply with the current requirements. The minimum program of the regional air quality monitoring system in the Dnipropetrovsk region has been scientifically substantiated
Physical Therapy of Footballers with Joints Hypermobility Signs after Ankle Sprains
Authors:   Dnipro State Medical University. 9, V. Vernadsky St., Dnipro 49000, Ukraine, Khomenko V. М. , Nekhanevych О. B.
Published: June 2021

Ankle sprains are one of the most common injuries in both athletes and the general population. The peculiarity of the consequences of injuries of this localization is the high probability of repeated injuries. Of particular interest are athletes with hypermobility of the joints. The systematic involvement of connective tissue in hypermobility of the joints affects the condition of the musculoskeletal system, in particular the ligament, can determine the effects of damage to the ankle and be a criterion for the differentiated use of physical therapy. The high percentage of recurrent ankle sprains injuries and significant structural, functional and professional consequences for footballers indicate an insufficient study of this problem both in terms of the mechanisms of recurrence of injuries and appropriate rehabilitation measures, which requires further scientific research and justification. The purpose of the study was to investigate the effectiveness of the developed physical therapy program of ankle sprains in football players with signs of hypermobility of the joints. Materials and methods. To achieve this goal, the data of 46 high-class football players of the Youth and the National Football Team of Azerbaijan aged 16 to 34 with acute damage to the communication apparatus of the ankle were analyzed. Patients were divided into study groups (main and control) of 23 individuals each using a simple randomization procedure. The main group used the proposed differentiated method of physical therapy taking into account the degree of hypermobility of the joints, which included early mobilization of ankle in the antero-posterior direction, stabilization of ankle due to early inclusion of exercises to train static balance, proprioceptive and plyometric training. Particular attention was paid to early neuromuscular control training. In the control group, athletes underwent rehabilitation according to generally accepted methods. The duration of the intervention was 4 weeks. Results and discussion. The degree of hypermobility of the joints, the volume of movements in the ankle, the limitations of daily and sports activity, pain levels, impaired sensorio-motor and postural control, static and dynamic balance were assessed. The results of the study indicate a high frequency of recurrence of ankle sprains in football players, accompanied by a complex of morphological, functional, sensory-perceptual disorders and disorders of neuromuscular control and, as a consequence, leads to limitations of daily life and sports activity. Conclusion. The application of the developed method of physical therapy in football players, taking into account the degree of systemic involvement of connective tissue is an effective means of preventing recurrent injuries, leading to faster restoration of morphological and functional integrity of the joint
Professional Competence of Instructors of Physical Training and Sports of Internal Affairs Bodies
Authors:   Ivan Boberskiy Lviv State University of Physical Culture. 11, Kostiushko St., Lviv 79000, Ukraine, Shvets V. L. , Pavlova Iu. O. , Bodnar I. R.
Published: June 2021

The existing model of professional training of police officers in Ukraine by many criteria does not meet the growing needs of society and generally accepted international democratic standards in this area. In these conditions, there is a growing need to reform the education system of future police officers in the Free Economic Zone of Ukraine. The purpose of the study was to clarify the components of the professional competence of instructors in physical training and sports of law enforcement agencies. Materials and methods. Theoretical analysis and generalization of data of special scientific and methodical literature were used in the work, monitoring of information resources of the Internet was carried out. It is established that the current problems that need to be addressed are the lack of a system of centralized training of instructors in physical training and sports, imperfection of the system of implementation of scientific developments in the field of physical culture and sports in practical service and combat activities and failure to take into account the initial level of training of cadets. Results and discussion. The analysis of experience of armies of the leading countries of the world shows that one of characteristic aspects in the organization of preparation of experts in physical training and sports is a combination in performance of tasks of physical training and mass sports. As part of the centralized training of personnel, the practice of using simulation centers and the Joint Conflict and Tactical Simulation software is widespread at the training courses for personnel of brigade headquarters (battalions). Promising areas for improving the professional training of instructors of physical training and sports are the use of distance, simulated learning, interactive, situational, game and project methods. Conclusion. Education of physical training and sports instructors requires a comprehensive approach and is carried out by a rational combination of basic types of training. It is established that the components of professional training of instructors of physical training and sports in military institutions are communicative, methodical, organizational-managerial and leadership competencies. The key issues of professional competence of instructors of physical training and sports are organizational and managerial skills. Organizational and managerial competence involves the formation of information-analytical, organizational, control and diagnostic skills. Important functions of heads of departments, instructors of physical training and sports are planning, definition of the purposes, coordination and the logical organization of professional activity of subordinates
Digital Literacy and its Acquisition by Teachers and Principals at Educational Workplaces
Authors: Tabieh Ahmad A. S. , Hamzeh Mohammad , Abu-Foudeh Basel Kh. S. , Jarrar Niveen , Al-Manaseer Sahar , Al-Shawabkeh Aysha , Seikaly Rania
Published: June 2021

This study investigates the digital literacy skills among workers in the educational workplace in Jordon. A convenience sample of 139 teachers and 73 administrators spread over 173 public schools and 39 private schools was selected. The study followed mixed quantitative and qualitative methods. Data were collected using two instruments: a semi structured interview to investigate and monitor the digital literacy skills; a questionnaire to measure the availability degree of the digital literacy skills and the significant differences in the availability degree due to the job title and the workplace. In this study, four areas represent digital literacy skills: functional skills, information skills, digital competency in the educational process and digital competency in empowering learners. The availability degree of digital skills is medium in general and statistically significantly higher in administrators than in teachers. The results showed that private sector workers have better digital literacy skills than their public sector peers. Finally, the study concluded that functional and information skills increase digital competency in the educational learning process and empower learners.
Chronometric Constructive Cognitive Learning Evaluation Model: Measuring the Consolidation of the Human Cognition Schema in Psychology Students’ Memory
Authors: Morales-Martinez Guadalupe Elizabeth , Hedlefs-Aguilar Maria Isolde , Trejo-Quintana Janneth , Mezquita-Hoyos Yanko Norberto , Sanchez-Monroy Miriam
Published: June 2021

This study illustrates the application of the Chronometric Constructive Cognitive Learning Evaluation Model to assess learning about human cognition knowledge schema in 48 second-year psychology students (79% females, 21% males). In the first phase, the participants carried out a conceptual definition task based on the Natural Semantic Networks technique. They defined ten target concepts related to the course by using verbs, substantives, adjectives, and pronouns (definers). Participants then rated the grade of relatedness between definers and targets concepts. Subsequently, the present authors carried out a computational simulation with data from the first study. In addition, students participated in a semantic priming experiment. They participated in a lexical decision task. Participants read pairs of words; these pairs were sometimes related by cognition scheme or common association, and sometimes were unrelated. The three tasks were applied at the start of the course and the end. The computational simulation analysis and ANOVA indicated that the initial pattern for conceptual activation had changed at the end of the course. Additionally, the initial chronometric behavior of the human cognition schema of the participants also changed at the end of the course. This evidence supports the idea that cognitive evaluation tools can help assess the schematic behavior patterns induced by academic learning.
Case of recurrent pulmonary thromboembolism due to therapeutic non-compliance
Authors:   1MD. Mihaela ANGHELE: CLINICAL-MEDICAL Department, «Dunarea de jos» University of Galati, Faculty of Medicine and Pharmacy, Galati, Romania. 2MD. Liliana DRAGOMIR: CLINICAL-MEDICAL Department, «Dunarea de jos» University of Galati, Faculty of Medicine and Pharmacy, Galati, Romania. 3PH.D. Virginia MARINA: MEDICAL Department of Occupational Health, «Dunarea de jos» University of Galati, Faculty of Medicine and Pharmacy, Galati, Romania.
Published: June 2021

Pulmonary embolism occurs when thrombi enter the pulmonary arterial circulation. Most pulmonary embolisms are the result of deep venous thrombosis of the pelvic limbs, chest or pelvis, and, less commonly, the jugular veins or inferior vena cava. Venous thromboembolism includes deep vein thrombosis and pulmonary embolism. It is the third most common cardiovascular disease, with a total annual incidence of 100-200 per 100 000 population. INTRODUCTION: Acute pulmonary embolism is the most serious clinical presentation of venous thromboembolism. Overall, pulmonary embolism is a major cause of mortality, morbidity and hospitalization. Mortality in pulmonary embolism depends on haemodynamic impairment, age and co morbidities. The prognosis of patients with pulmonary embolism depends on two factors : underlying disease state plus diagnosis, and appropriate treatment. Approximately 10% of patients who develop pulmonary embolism die within the first hour, and 30% subsequently die of recurrent embolism. CASE PRESENTATION: In this presentation we present the case of a 49-year-old male patient without co morbidities, presented repeatedly to the Emergency Room for symptoms suggestive of pulmonary thromboembolism, who benefited from life-saving therapies due to timely diagnosis and appropriate treatment, with subsequent favorable outcome. CONCLUSIONS: The particularity of the case is that, on the one hand, the thromboembolic event recurred in a short time, on the other hand, the evolution was favorable in both cases, with complete recovery of right ventricular function and disappearance of pulmonary hypertension, despite the fact that the patient was non-compliant with initial anticoagulation therapy. This was due to both early diagnosis and timely administration of appropriate treatment.
The Effect of Rewards on Work Commitment of Nurses at Surgical and Medical Section (SMS) of National Hospital
Authors: Senanayake C. M.
Published: June 2021

Background: Nurses are an essential component of health workforce. Therefore rewarding nurses is important to provide better service to the clients. The main purpose was to describe the effect of rewards on the work commitment of nurses at the SMS of National hospital. Objectives: to identify intrinsic and extrinsic rewards cause to the level of work commitment of nurses at SMS of National hospital, to determine the level of work commitment of nurses at SMS of National hospital, to measure the effect of socio-demographic factors on work commitment of nurses at SMS of National hospital and to describe the effect of rewards on work commitment of nurses at SMS of National hospital. Methodology: Descriptive, hospital-based, cross-sectional study design was used. Simple random sampling used to select 384 nurses. Data was collected using a self-administered questionnaire. Results: The mean value for composite intrinsic rewards was 3.34 (SD = 0.57). There is a moderately positive Correlation (r = 0.327, p< 0.000) between intrinsic rewards and the work commitment. The mean value for composite extrinsic rewards was 2.54 (SD = 0.71) and it shows a very weak positive Correlation (r = 0.167, p< 0.002) between extrinsic rewards and work commitment. As Socio-demographic factors, gender (0.016**), age group (0.117*), position (0.114*), working experience at current work place (0.154*), and working section (0.014**) have association with the overall work commitment of nurses. Level of work commitment of nurses was moderate (Mean = 3.13, SD = 0.35). Conclusion: Moderate correlation means, when increases intrinsic rewards, nurses’ work commitment can be increased. Extrinsic rewards also cause to increase the commitment. Socio-demographic factors have an association with overall work commitment. These results help nurse managers to improve existing intrinsic rewards for nurses to enhance work commitment. Nurse Managers should suggest and plan a good reward system for nurses. Further research wants to conduct in government and private hospitals to find out ways to make nurses more committed. Moderate work commitment may be due to inadequate rewards or actually their dedication to the service without expecting rewards. Doi: 10.28991/SciMedJ-2021-0303-4 Full Text: PDF