bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic causes of hearing loss at children
Authors:   Universitatea de Medicină și Farmacie „Gr. T. Popa“, Iaşi, PALADE Dragoş , TOADER Mioriţa ,   Spitalul Clinic de Copii „Grigore Alexandrescu“, Bucureşti, TOADER Corneliu ,   Institutul Naţional de Neurologie şi Boli Neurovasculare, Bucureşti, OPREA Alina ,   Spitalul Clinic de Copii „Grigore Alexandrescu“, Bucureşti, DRĂGHICI Mircea ,   Dentirad Hospital, Ploieşti
Published: September 2021

Hearing loss is a major public health problem, with an incidence of about 1 in 1,000 newborns. The causes which determine the loss of hearing are multiple and can be of genetic or non-genetic causes. Among child hearing loss, 50% are caused by genetic causes. A significant importance is given to the GJB2 (connexin 26) gene which is responsible for more than half of causes of hearing loss determined by genetic factors. The authors expose an overview of the main significant genetic factors for the hearing loss at pediatric population.
Chronic urticaria through food sensitization. Clinical study
Authors:   Universitatea „Dunărea de jos“, Galaţi, UNGURIANU A. , SOLOVĂSTRU Laura Gheucă ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“ Iaşi, Clinica Dermato-venerologie, DIACONESCU Smaranda ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“ Iaşi, SINIŢCHI Georgeta ,   Universitatea „Apollonia“, Iaşi,   Centrul Medical Alergologic „Atopia“, Iaşi
Published: September 2021

Food allergies have become a public health problem, exceeding 3.27-5% of the local population. Knowledge of food allergens is required. Material and methods. Our study comprised 100 patients with chronic urticaria caused by food sensitization, selected from a total of 252 patients with chronic urticaria different causes. Discussions. Chronic urticaria study group had a food issue and awareness (40%); sensitization was caused by foods known as sensitizing: egg, fish, shellfish, strawberries, nuts, seeds, raspberries, strawberries, soy, celery; the land was hereditary and personal allergic to very high percentage (79%); changes in quality of life was found in 80%. Repeated and abusive food consumption with irregular mealtimes is another contributing factor. Conclusions. Chronic urticaria with food sensitization is one of the manifestations of pathology that can be assigned to XXI century diseases. Cooperation between the family doctor, dermatologist, allergist is required.
Spinal cord tumor hidden by comorbidities
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“ Bucureşti, MIHĂILESCU Gabriela ,   Spitalul Clinic Colentina, Secţia Neurologie I
Published: September 2021

Comorbidities present in complex cases can frequently hide new diseases, may influence treatment decisions and can augment risks. The nonvalvular atrial fibrillation is a risk factor for inducing stroke, but treated with anticoagulant drugs in a right way atrial fibrillation is not responsible for the onset of all new motor deficits in a patient. The anamnesis, the thorough clinical neurological examination, associated with specific paraclinical diagnosis methods can lead to the right diagnosis, showing, in this specific case presented, a meningioma of the spinal cord localised in the high cervical region, treated by neurosurgery.
Family’s physician and therapeutic education of the family and patient with Alzheimer’s disease
Authors:   Universitatea „Apollonia“, Iaşi, SINIŢCHI Georgeta
Published: September 2021

Alzheimer’s disease is the disease responsible for dementia and is a major concern for public health in all countries of the world. People over the age of 65 have a prevalence of the disease of about 5%. The disease is chronic, with an evolution of many years after the diagnosis was made. The duration can be of 4-8 years, depending on the age of the patient and the stage of the diagnosed disease. The number of cases grows constantly along with the rise in number of elders and life expectancy. It is expected, based on the years 2010-2015, a bigger rise in case numbers. The nursing costs is also rising. Dementia of Alzheimer’s disease has a common characteristic of global malfunctioning cognitive functions, bringing a loss of functional independence. The patient need a caregiver for the normal life: budget management, using the phone, public transport, cooking a meal. The patient’s autonomy loss obliges the entourage to mobilize in order to measure the disease’s evolution and the loss of independence. Patients have behavioral disorders and/or of the psychiatric simptomes. In advanced stages, the verbal communication with the pacient becomes difficult, leading to language disorders and agnosia. The treatment of Alzheimer’s disease relies on inhibitors of acetylcholinesterase and memantine. Sometimes psychotropics are needed. Along with these, care like: trained caregiver, home meal delivery, legal advice, psychological support, information about the disease, the staff training and knowledge of pursuing the best and efficient international studies about the disease. Conclusion. The social and healthcare system and preserving the balance between these difficult situations will be in accordance with the growth of knowledge in the field and will lead to the integration of therapeutic education of families and of the people with Alzheimer’s disease, in which the family’s physician has an important role.
The Influence of Accounting Information on Stock Prices of Food and Beverage Manufacturing Companies
Authors: Oleyinka Okeyo , Chadire Tyronni
Published: September 2021

The purpose of this study is to determine the effect of accounting information on stock prices of manufacturing companies in the food and beverage sub-sector This research takes place at the Stock Market  office. The sample selection method in this study is a purposive sampling method with a total sample of 5 companies. The data collection techniques collect data on the company's financial statements during the research period. The data analysis method used was multiple regression with the help of SPSS for windows 25.00 software. The results showed that 1) Based on the results of data analysis, the coefficient values ​​of ROA, ROE, NPM, and EBIT showed an effect on stock prices simultaneously. 2) Based on the results of data analysis ROA, ROE, NPM partially significant effect on stock prices, while EBIT has no effect on stock prices of manufacturing companies in the food and beverage sub-sector on the Stock Market. 3) The most dominant variable that influences ROA, ROE, NPM and EBIT on stock prices of manufacturing companies in the food and beverage sub-sector on the Stock Market is the ROA variable
An Analytical Study of Selected Development Banks in India
Authors: Vithalbhai Vasani Sureshbhai
Published: September 2021

The economic development of any country depends on the extent to which its financial system efficiently and effectively mobilizes and allocates resources. After the Second World War, Industrialized and less developed countries have tried to bridge long-term financing needs through the creation of national development banks for finance so, the researcher wanted to know about financial parameters related to developmental banks and to study an analytical study of selected banks. The researcher has used components like Deposits, Investments, Loans and Advances, Borrowings, Fixed assets, and other assets to an analysis of performance. The researcher has selected the period of study 6(six) years which are 2014-15 to 2019-20. The researcher has used the ANOVA test for the analysis of the performance of selected Development Bank in India. The researcher has found the highest amount of deposit has been found in NABARD and SIDBI and EXIM on second and third rank respectively. The trend of deposit in SIDBI, NABARD shows a continued upward trend, but in EXIM bank deposits shows decreasing level by comparing to the base year. During the period of study in 2018 trend of deposits decreased by 9.27 in EXIM bank. By applying ANOVA deposits of three selected development banks found 8.49 is calculated value and 3.68 is table value at the 5% level of significance, so, the null hypothesis is rejected it means there is a significant difference in the Deposits and other finding included in the research paper.
NARRATIVAS DE ESTUDANTES DA EJA NO CONTEXTO DA PANDEMIA DA COVID-19
Authors: Sousa Gilvan dos Santos , Santos Jaciara de Oliveira Sant'´Anna , Júnior Adenilson Souza Cunha
Published: September 2021

O presente trabalho objetiva discutir, por meio da análise de narrativas de estudantes da EJA, o papel do professor no processo de amorosidade e acolhimento desses sujeitos, durante o período de pandemia e o fechamento das unidades. Acredita-se que o aspecto da amorosidade é de fundamental importância no contexto atual para a permanência desses sujeitos na escola. No percurso metodológico, optou-se pela abordagem qualitativa, desenvolvida a partir de narrativas desses protagonistas. O estudo dividiu-se em dois períodos. No primeiro, fez-se revisão bibliográfica e análise documental. No segundo momento, realizou-se a análise de relatos de seis estudantes do Ensino Fundamental II da EJA de uma escola pública municipal de Vitória da Conquista. Os resultados demonstram a necessidade de a sala de aula ser um espaço humanizador de diálogo e escuta, propiciando acolhimento.
Numerical Analysis of the Ability of a Floating Vehicle to Overcome a Water Obstacle
Authors: Kosiuczenko Krzysztof , Sosnowicz Robert
Published: September 2021

The paper presents the results of simulation tests of the entry of a floating transporter to a water obstacle. The simulation tests were performed with the use of LS Dyna program, based on the finite element method (FEM). The computational model was developed and used in the simulation of the manoeuvre of entering the water obstacle for the extreme conditions, which are described by NATO standards. For a model, as an example vehicle, the floating transporter PTS-M was used. The results of the application of the elaborated model confirmed the possibility to utilise the method to verify the behaviour of a vehicle in a very important and difficult problem from the point of view of vehicle safety conditions.
Pholcus maxian sp. nov., the fifth endemic spider species of Pholcus phungiformes species-group (Araneae: Pholcidae) at the border between Jilin, China and North Korea
Authors: Lu Ying , Yang Fan , He Qiaoqiao
Published: September 2021

The distribution pattern of Pholcus phungiformes species-group indicates that, in Jilin and Heilongjiang, China and North Korea, additional species diversity remains undiscovered.

Pholcus maxian sp. nov., one new species of P. phungiformes species-group, is described, based on material collected from the borderline between Jilin, China and North Korea. It represents the fifth endemic species of this species-group and the genus Pholcus from this region.
Pediatric-inspired regimen with late intensification and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study
Authors: Baek Dong Won , Kim Dae Young , Sohn Sang Kyun , Koh Youngil , Jung Sung-Hoon , Yhim Ho-Young , Choi Yunsuk , Moon Joon Ho
Published: September 2021

Background/Aims: The objective of this study was to evaluate the efficacy and feasibility of the pediatric-inspired regimen of the adult acute lymphoblastic leukemia (ALL) Working Party, the Korean Society of Hematology.Methods: Data of 99 patients with newly diagnosed ALL, who were treated with the KALLA 1406/1407 protocol, were retrospectively analyzed. All patients equally received age-adjusted daunorubicin, vincristine, and prednisolone. L-asparaginase was additionally administered to Philadelphia (Ph)-negative patients according to age, whereas Ph-positive patients received 600 mg/day of imatinib.Results: A total of 99 patients were enrolled in this study, of whom 62 (62.6%) were diagnosed with Ph-negative ALL and 37 (37.3%) were diagnosed with Ph-positive ALL. The median age of patients in the Ph-negative ALL group was 46 years, and that of patients in the Ph-positive ALL group was 49 years. In patients with Ph-negative ALL, 57 (92%) patients achieved complete remission (CR) and CR with incomplete hematologic recovery (CRi). Disease-free survival (DFS) and overall survival (OS) rates at 2 years were estimated to be 42% and 63%, respectively. In patients with Ph-positive ALL, 32 (86%) patients achieved CR/CRi, and 2-year DFS and OS were 31.2% and 49.1%, respectively. Patients who were able to proceed to the allogeneic hematopoietic cell transplantation and younger patients showed significantly superior survival in both Ph-negative ALL and Ph-positive ALL. Neutropenic fever and bacterial infection were the most common and severe adverse events.Conclusions: The KALLA 1406/1407 protocol showed tolerable toxicities in adult ALL patients. Especially, younger patients had more survival benefits with KALLA 1406/1407 protocol.
Elle ou il apprend l’allemand. Manuels scolaires et grammaires au prisme du genre
Authors: Schnitzer Nathalie
Published: September 2021

En allemand comme en français, genre grammatical et genre biologique ne sont que partiellement corrélés. À cela s’ajoute la question du genre social ( gender ), né des revendications féministes de la seconde moitié du XX e  siècle. Dans les pays de langue allemande, la communication équitable en genre est déjà bien entrée dans l’usage. En France, la discussion autour de l’écriture inclusive reste un sujet polémique. L’objectif de cette contribution est de voir si la demande d’une meilleure visibilité des femmes en langue et en discours a eu des répercutions sur le traitement du genre dans les supports pédagogiques dédiés à l’enseignement de l’allemand en France. L’analyse porte sur une sélection de manuels scolaires d’allemand de collège, les uns antérieurs à 1970, les autres postérieurs à l’an 2000. Elle est complétée par l’étude de plusieurs grammaires d’apprentissage de l’allemand diffusées en France depuis une trentaine d’années. L’analyse de ce corpus révèle que les manuels de collège de la première décennie du XXI e  siècle prennent en compte, à des degrés divers, la notion d’équité en genre, contrairement aux grammaires de l’allemand publiées dans la même période, voire plus récemment.
La narration au féminin : ce que le genre a fait à une carrière d’universitaire entre l’Autriche et la France
Authors: Ott Herta-Luise
Published: September 2021

Cette contribution, qui n’est pas conçue malgré les apparences comme une rétrospective autobiographique, se propose d’exposer derrière l’enchaînement chronologique un système de contradictions articulées les unes aux autres, en dépit de leur spécificité. Elles sont au nombre de trois principalement. L’une de nature sociale dynamise le passage d’une jeune écolière d’abord scolarisée dans l’enseignement professionnel, y compris ménager, à l’univers social des universitaires. La deuxième, de nature plus culturelle et nationale, installe cette transition dans les différences des systèmes universitaires autrichiens et français. La troisième, plus globale, structure la difficulté, inégale d’un pays à l’autre, de faire entendre des voix féminines dans des univers intellectuels dominés d’inégale façon par les traditions masculines. Les objets littéraires des travaux engagés à mesure par l’auteure définissent peu à peu un itinéraire dont les principales « stations » sont dans un premier temps Marguerite Duras, Ingeborg Bachmann, Marguerite Yourcenar, suivies, plus tard, d’auteures (et auteurs) considéré(e)s comme moins canoniques, souvent plus jeunes, qui partagent toutes et tous le souci de faire entendre des voix singulières en proie à la fois à leurs propres antinomies genrées et à celles de la société.
Le genre de l’extrême droite : les femmes du NPD
Authors: Dubslaff Valérie
Published: September 2021

Cette contribution s’intéresse à l’utilisation que je fais du « genre » comme catégorie d’analyse dans ma thèse de doctorat. Celle-ci sonde, sur plus d’un demi-siècle, les parcours, les pratiques et la participation politiques de dirigeantes et militantes du Parti national-démocrate d’Allemagne (NPD), parti néonazi fondé en 1964 en Allemagne de l’Ouest. Partant du constat de l’absence des femmes dans l’historiographie traditionnelle, l’article entend démontrer la pertinence des approches genrées en présentant la démarche, les questionnements et les sources qui ont permis d’étudier l’histoire et l’ agency d’actrices nationalistes évoluant dans un milieu fortement dominé par les hommes.
M. le maudit
Authors: Henry Bénédicte
Published: September 2021

Souffrant de troubles du comportement, un enfant scolarisé en primaire est accompagné par une enseignante spécialisée, auteure de l’article. Alors que la France est secouée par une succession de drames à caractère terroriste, le jeune garçon est accusé de faire l’apologie du terrorisme. L’institution décide de l’exclure.
Réussir à l’école ?
Authors: Kamieniak Jean-Pierre
Published: September 2021

Si le savoir caractérise manifestement l’asymétrie de la relation pédagogique, cette dernière ne peut bien évidemment s’y réduire : elle s’appuie sur cette autre relation, plus fondamentale, non modifiable, consistant à mettre en présence deux êtres ou deux sujets dont l’un – immature ou inachevé et en voie de construction – a besoin de cet autre, l’adulte, afin de mettre à l’épreuve et de consolider les processus psychiques constitutifs de sa personnalité, alors en voie d’élaboration. De fait, la méconnaissance active de cette dimension libidinale sous-jacente à la pratique pédagogique, dont témoigne le système éducatif, contribue largement aux accrocs et aux ratés de cette dernière.
Les richesses de la pleine conscience
Authors: Olendzki Andrew
Published: September 2021

La pleine conscience est examinée en utilisant le système Abhidhamma de classification des phénomènes (dharmas) tel qu’on le trouve dans l’ouvrage Abhidhammattha-saṅgaha. Dans ce modèle, les facteurs mentaux qui constituent l’agrégat de formations (saṅkhāra) sont groupés de telle manière qu’ils décrivent une approche stratifiée de la pratique du développement mental. Ainsi, tous les états mentaux impliquent une certaine gamme de facteurs mentaux, et d’autres y sont ajoutés à mesure que l’entraînement de l’esprit évolue. Les configurations saines et malsaines se produisent également, et la pleine conscience s’avère être l’état assez avancé d’une expérience saine et construite. La sagesse, qui constitue le facteur transformateur premier dans la pensée et la pratique bouddhistes, n’advient qu’à partir de conditions spéciales. Ce système est ensuite comparé avec une analyse différente des phénomènes telle qu’on la présente dans l’Abhidharmakośa sanskrit, où la pleine conscience et la sagesse sont comptées parmi les facteurs universels, ce qui propose une base pour un modèle innéiste ; ceci est ensuite critiqué à partir d’une perspective constructiviste.
Appels de Jacques Derrida
Authors: Odello Laura
Published: September 2021

Walten is an enigmatic motif that insists in Jacques Derrida’s last seminar, where it seems to lead towards a re-elaboration of the concept of sovereignty. In The Beast and the Sovereign, Derrida explores the powerful overtones of the Walten in Heidegger’s work, showing that Walten can no longer be reduced to an onto- theologico-political sovereignty already in deconstruction. This article tries to understand the excessive “force” of Walten that Derrida defines as being sovereign beyond sovereignty.
Appels de Jacques Derrida
Authors: Ferrario Edoardo
Published: September 2021

What is the divide between name and sign, between a name, which is untranslatable even within a language, and a noun, which is thought to be indefinitely translatable into all languages? Is this divide truly indivisible, or does it not cross the terms of the dyad, dividing itself and each one of them? This text examines the law, or in other words, the “double law” governing this partage in Derrida’s thought and in his writing.
Appels de Jacques Derrida
Authors: Moati Raoul
Published: September 2021

Nous proposons dans ce texte de revenir sur les enjeux de « Signature, Événement, Contexte », texte paru en 1972 dans Marges. De la philosophie , en concentrant notre attention sur l’approche déconstructrice de la notion pragmatique de « contexte » avancée par Jacques Derrida. En quoi une telle déconstruction remet-elle en jeu la notion de contexte plutôt qu’elle ne l’abolit ? Telle est la question directrice de cette étude.
Appels de Jacques Derrida
Authors: Vitale Francesco
Published: September 2021

Cet essai présente la première étape d’une recherche en cours dont l’ambition serait de montrer le rôle joué par la question de la « vie » dans toute l’élaboration de la déconstruction . Il s’agit de détecter dans l’œuvre de Derrida les traces d’une confrontation critique avec les sciences de la vie (la paléontologie, l’ethnologie préhistorique, l’éthologie et surtout la biologie et la théorie de l’évolution). Dans cette première étape, la notion de «  via rupta  », maintes fois utilisée par Derrida, nous aide à cerner l’émergence de l’« archi-écriture » qui structure la « conscience » avant la distinction entre l’homme et l’animal, et plus précisément, dans la lutte pour la survivance qui conditionne la vie du vivant dans son habitat.
Appels de Jacques Derrida
Authors: Mallet Marie Louise
Published: September 2021

“But I wonder if philosophy, which is also the birth of prose, has not meant the repression of music or song. Philosophy cannot, as such, let song resonate in some way,” writes Jacques Derrida. Thus, one shall not find in his writings a new “philosophy,” “theory” or “aesthetics” of music. One shall find better: his work as a thinker opens up a path towards music and listening, a path that had long been obstructed by philosophy’s canonical tradition due to an quasi structural requisite.
Interpreting John Zorn’s Spillane (1986) as a Sonic Detective Novel or Film Noir
Authors: Windleburn Maurice
Published: September 2021

Cet article propose une interprétation de l’œuvre Spillane (1986) du compositeur américain contemporain John Zorn. Spillane est la plus connue des compositions file card de Zorn et l’une de ses œuvres les plus régulièrement mentionnées. Elle est dédiée à Mickey Spillane – un écrivain de fiction policière hard-boiled – ainsi qu’au genre cinématographique du film noir, avec la présence de nombreuses allusions intertextuelles à des romans et des films auxquels la composition de Zorn fait référence. Sur la base de ces allusions, la pièce de Zorn est ici interprétée comme s’il s’agissait d’un roman de Spillane ou d’un film noir : une composition avec sa propre diégèse, faite de sons et d’associations extra-musicales. Cette diégèse est analysée à partir d’idées tirées du discours sur les ouvrages de Spillane et sur le film noir – en particulier dans le domaine de la critique littéraire et cinématographique de nature psychanalytique.
Parures florales : des corps politiques dans l’espace public, de la Restauration à la Deuxième République (1814-1852)
Authors: Fureix Emmanuel
Published: September 2021

Au cours du premier xix e  siècle, la politisation des individus se donne à voir à travers toute une gamme de signes exhibés dans l’espace public. Parmi ces signes, les fleurs, portées à la boutonnière, ou comme motifs inscrits sur le vêtement lui-même, occupent une place centrale. Lys, violettes, œillets rouges, thym, rendent visibles des identités politiques assumées ou postulées. Sur les promenades publiques, dans les cabarets ou les bals publics, ces fleurs portées avec affectation deviennent des objets de conflit, avec leur lot de bravades, défis, rixes plus ou moins violentes. L’article, centré sur des archives administratives, policières et judiciaires, s’attache à montrer la conflictualité autour de ces fleurs, séditieuses ou non. Il montre les liens entre des parures florales et une citoyenneté agonistique, dominante dans la première moitié du xix e  siècle, de la Restauration à la Deuxième République.
Invisibiliser le relèvement de l’indemnité des parlementaires français, un enjeu de l’entre-deux-guerres
Authors: Le Saout Rémy
Published: September 2021

Dans l’entre-deux-guerres, l’indemnité des parlementaires français a fait l’objet de quatre lois qui en revalorisent le montant. Mais ce travail législatif s’inscrit surtout dans la recherche de dispositifs qui rendent ces augmentations discrètes, préfigurant par-là l’adoption ultérieure, en 1946 et 1958, de dispositions qui stabilisent et consolident une réglementation toujours en vigueur aujourd’hui. Bien qu’essentiel dans le processus d’institutionnalisation de l’indemnité parlementaire, ce sujet n’a guère retenu l’attention de la recherche. Cet article vise à rendre compte des confrontations et de jeux de négociations qui, entre les années 1920 et 1930, ont contribué à normaliser l’invisibilisation du relèvement de l’indemnité parlementaire.
La réception sociale de la gestion du risque littoral : un éclairage au prisme de la simulation participative
Authors: Amalric Marion , Becu Nicolas
Published: September 2021

En proposant des modes alternatifs de gestion du risque littoral, les pouvoirs publics français font face aux réticences des collectivités locales. La réception sociale de la gestion du risque se pose d’autant plus que la perspective des effets du changement climatique rend le besoin de définir de manière de plus en plus prégnante, des stratégies optimisées et à long terme. En se basant sur une expérience de simulation participative, nous montrons comment se constitue le processus de réception sociale d’une politique de gestion du risque, en présentant une étude de cas à Oléron, pendant laquelle les participants à des ateliers expérimentent des modes de gestion alternatifs du risque de submersion. L’article montre que la mise en place d’un dispositif participatif permet de qualifier la réception sociale d’une politique publique de gestion du risque, du point de vue des connaissances sur les risques, des échelles de gestion des risques littoraux et de la sensibilité aux effets du changement climatique. Le dispositif s’avère une manière pour les participants des ateliers de s’emparer des arènes de débat que constituent les ateliers : la discussion montre qu’il s’agit d’une forme de « débordement » du dispositif scientifique, au service de l’appropriation de la politique publique.
Khmers contre Khmers
Authors: Margolin Jean-Louis , Taïbi Nadia
Published: September 2021

En 1975, au Cambodge, nous sommes face à un crime d’une ampleur extraordinaire, accompagné de pratiques extrêmement radicales, elles-mêmes sources de violence : fermeture instantanée des villes, abolition complète de la monnaie et des relations marchandes, abolition totale de la propriété privée – jusqu’au moindre vêtement ou ustensile de cuisine –, abolition également du droit à se nourrir soi-même […] Les familles sont dissoutes, les enfants sont séparés des adultes. On interdit toute forme de déplacement autre que de travail et bien entendu toute espèce de fête ou de célébration qui ne soit pas celle de la toute-puissante et mystérieuse Angkar Loeu – l’Organisation supérieure…
Nietzsche : par-delà la mémoire et l’oubli
Authors: Granarolo Philippe
Published: September 2021

L’instant zéro, entraînant éternellement son propre retour, n’est plus moment du temps, mais totalité du temps. Aussi paradoxal que nous apparaisse le commencement d’un temps sans commencement, la nouvelle temporalité dans laquelle Nietzsche a pénétré un beau jour d’août 1881 est celle d’un éternel commencement…
Multiplicity of positive solutions to semi-linear elliptic problems on metric graphs
Authors: Shibata Masataka
Published: September 2021

We consider positive solutions of semi-linear elliptic equations

   \begin{document}$ - \epsilon^2 u'' +u = u^p $\end{document}

on compact metric graphs, where \begin{document}$ p \in (1,\infty) $\end{document} is a given constant and \begin{document}$ \epsilon $\end{document} is a positive parameter. We focus on the multiplicity of positive solutions for sufficiently small \begin{document}$ \epsilon $\end{document}. For each edge of the graph, we construct a positive solution which concentrates some point on the edge if \begin{document}$ \epsilon $\end{document} is sufficiently small. Moreover, we give the existence result of solutions which concentrate inner vertices of the graph.
Quantum Hermite-Hadamard type inequalities for generalized strongly preinvex functions
Authors: Kalsoom Humaira ,   Department of Mathematical, Zhejiang Normal University, Jinhua 321004, China, Latif Muhammad Amer , Idrees Muhammad , Arif Muhammad , Salleh Zabidin ,   Department of Basic Sciences, Deanship of Preparatory Year, King Faisal University, Hofuf 31982, Al-Hasa, Saudi Arabia,   Zhejiang Province Key Laboratory of Quantum Technology and Device, Department of Physics, Zhejiang University, Hangzhou 310027, China,   Department of Mathematics, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan,   Department of Mathematics, Faculty of Ocean Engineering Technology and Informatics, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia
Published: September 2021

In accordance with the quantum calculus, the quantum Hermite-Hadamard type inequalities shown in recent findings provide improvements to quantum Hermite-Hadamard type inequalities. We acquire a new $ q{_{\kappa_1}} $-integral and $ q{^{\kappa_2}} $-integral identities, then employing these identities, we establish new quantum Hermite-Hadamard $ q{_{\kappa_1}} $-integral and $ q{^{\kappa_2}} $-integral type inequalities through generalized higher-order strongly preinvex and quasi-preinvex functions. The claim of our study has been graphically supported, and some special cases are provided as well. Finally, we present a comprehensive application of the newly obtained key results. Our outcomes from these new generalizations can be applied to evaluate several mathematical problems relating to applications in the real world. These new results are significant for improving integrated symmetrical function approximations or functions of some symmetry degree.
Construction and validation of a novel prognostic signature for uveal melanoma based on five metabolism-related genes
Authors: Zhao Han ,   Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China, Chen Yun , Shen Peijun , Gong Lan ,   Laboratory of Myopia, NHC Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, Shanghai, China,   Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China,   Department of Stomatology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China,   Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical University, Henan, China
Published: September 2021

Background

Uveal melanoma (UM) is the most aggressive intraocular tumor worldwide. Accurate prognostic models are urgently needed. The present research aimed to construct and validate a prognostic signature is associated with overall survival (OS) for UM patients based on metabolism-related genes (MRGs).

Methods

MRGs were obtained from molecular signature database (MSigDB). The gene expression profiles and patient clinical data were downloaded from The Cancer Genome Atlas (TCGA) database. In the training datasets, MRGs were analyzed through univariate Cox regression analyses and least absolute shrinkage and selection operator (LASSO) Cox analyses to build a prognostic model. The GSE84976 was treated as the validation cohort. In addition, time-dependent receiver operating characteristic (ROC) and Kaplan-Meier survival curve analyses the reliability of the developed model. Then, gene set enrichment analysis (GSEA) was used for gene enrichment analysis. Nomogram that combined the five-gene signature was used to evaluate the predictive OS value of UM patients.

Results

Five MRGs were identified and used to establish the prognostic model for UM patients. The model was successfully validated using the testing cohort. Moreover, ROC analysis demonstrated a strong predictive ability that our prognostic signature had for UM prognosis. Multivariable Cox regression analysis revealed that the risk model was an independent predictor of prognosis. UM patients with a high-risk score showed a higher level of immune checkpoint molecules.

Conclusion

We established a novel metabolism-related signature that could predict survival and might be therapeutic targets for the treatment of UM patients.
On some non-local approximation of nonisotropic Griffith-type functionals
Authors: Farroni Fernando ,   Dipartimento di Matematica ed Applicazioni "R. Caccioppoli", Università di Napoli Federico II, Via Cintia Monte Sant'Angelo, 80126 Napoli, Italy, Scilla Giovanni , Solombrino Francesco ,   Dipartimento di Scienze di Base e Applicate per l'Ingegneria (SBAI), Sapienza Università di Roma, Via A. Scarpa 16, 00161 Roma, Italy
Published: September 2021

The approximation in the sense of $ \Gamma $-convergence of nonisotropic Griffith-type functionals, with $ p- $growth ($ p > 1 $) in the symmetrized gradient, by means of a suitable sequence of non-local convolution type functionals defined on Sobolev spaces, is analysed.
Bootstrap With Cluster‐Dependence in Two or More Dimensions
Authors: Menzel Konrad
Published: September 2021

We propose a bootstrap procedure for data that may exhibit cluster‐dependence in two or more dimensions. The asymptotic distribution of the sample mean or other statistics may be non‐Gaussian if observations are dependent but uncorrelated within clusters. We show that there exists no procedure for estimating the limiting distribution of the sample mean under two‐way clustering that achieves uniform consistency. However, we propose bootstrap procedures that achieve adaptivity with respect to different uniformity criteria. Important cases and extensions discussed in the paper include regression inference, U‐ and V‐statistics, subgraph counts for network data, and non‐exhaustive samples of matched data.
La casa-patio de entramado de madera: construcción, transformación y rehabilitación de casas particulares, posadas y edificios de vivienda colectiva en Madrid
Authors: González-Redondo Esperanza
Published: September 2021

La casa-patio de entramado de madera, con galerías y cuartos perimetrales, es de gran interés constructivo pero complejo análisis. En Madrid, numerosas casas particulares, posadas y casas-patio colectivas, de obligada conservación (PGOUM,1997), no constan como nuevas construcciones (1494-1868). El descubrimiento de una ‘casa a la malicia’, que ocultaba una posada con ‘aposentillos’ formando un patio interior; y su posterior ampliación con otra crujía con corredor (1737), situará la transformación de las casas particulares de los arrabales en una nueva tipología, la casa-patio colectiva con cuartos de alquiler. Existirá una fase intermedia, la casa-patio de transición, de parámetros específicos. El análisis constructivo de proyectos antiguos con información en planta (1724-1788), fachadas de innumerables casas-patio conservadas o demolidas (1656-1868), y su levantamiento planimétrico, determinarán un modelo repetido denominado casa de vecinos y recientemente corrala. Tiene sectores estructuralmente diferenciables, viviendas-tipo en fachada y mínimas alrededor del patio, corredores, letrinas comunitarias y pozo.
ENVIRONMENTAL BENEFIT OF TWO-LAYER STEEL FIBERED HIGH-PERFORMANCE CONCRETE BEAMS
Authors: Pushkar Svetlana , Ribakov Yuri
Published: September 2021

This study evaluated Life-Cycle Assessment (LCA) of two different designs of high-performance concrete beam: (1) a single-layer beam (SLB) that consisted of steel fibered high-strength concrete in both the compression and tensile zones and (2) a two-layer beam (TLB) that consisted of steel fibered high-strength concrete and normal-strength concrete in the compression and tensile zones, respectively. The SLB and steel fibered high-strength concrete layer of the TLB were of the same concrete class C70/85. LCAs of the SLB and TLB were conducted using the ReCiPe2016 midpoint and endpoint-single-score methods. The difference between the two endpoint-single-score results was evaluated using a two-stage nested analysis of variance. The ReCiPe2016 midpoint results showed that replacing the SLB with the TLB reduces the environmental impact of global warming potential, terrestrial ecotoxicity, water consumption, and scarcity of fossil resources by 15%, 17%, 11%, and 17%, respectively. The ReCiPe2016 endpoint-single-score results showed that the environmental damage from the TLB compared to the SLB was statistically reduced (p = 0.0256). Therefore, considering two different designs of steel fibered high-strength concrete beams, the TLB design was found environmentally preferable to SLB design on both, midpoint and endpoint-single-score evaluations.
IMPACTS OF BUILDING FUNCTION ON NORMALIZED-STEAM CONSUMPTION: ANALYSIS OF FLOOR AREA NORMALIZATION VERSUS LINEAR REGRESSION ON HEATING DEGREE-DAYS IN A HEATING-DOMINATED CLIMATE
Authors: Mohajer Mahsa Farid , Aksamija Ajla
Published: September 2021

Linear regression analysis is one the most common methods for weather-normalizing energy data, where energy versus degree-days is plotted, quantifying the impacts of outside temperature on buildings’ energy use. However, this approach solely considers dry-bulb temperature, while other climate variables are ignored. In addition, depending on buildings’ internal loads, weather impact can be less influential, making the linear regression method not applicable for energy data normalization in internally driven buildings (such as research laboratory buildings, healthcare facilities, etc.). In this study, several existing buildings from different categories, all located on the University of Massachusetts Amherst campus and exposed to the same weather conditions in a heating-dominated climate, were analyzed. For all cases, regression of monthly steam use on heating degree-days and floor-area normalized steam data were used, investigating applicability of the former when the latter changes. It was found that internal loads can skew steam consumption, depending on the building functionality, making the effect of degree-days negligible. For laboratory-type buildings, besides heating and domestic hot water production, steam is also used for scientific experiments. Here, daily occupancy percentage, even during weekends and holidays, was higher than that of other buildings, indicating the intensity of scientific experiments performed. This significantly impacted steam consumption, resulting in higher floor-area-normalized steam usage. In these cases, steam use did not provide an outstanding correlation to heating degree-days. Whereas, for cases with other functionality-types and lower floor-area normalized steam, coefficients of determination in regressions were high. This study concludes that even for buildings located in the same climate, depending on how building functionality and occupancy schedule influence floor-area normalized steam use, multivariate linear regression can provide more accurate analysis, rather than simple linear regression of steam on heating degree-days.
Messengers of the University of Paris on the Paths of Humanism?
Authors: Hacke Martina
Published: September 2021

Humanism in Europe spread out along convoluted paths. As is well known, books played a major role in this, especially after the invention of printing. In particular, it was the travelling book dealers who transported writings with humanist content over long distances. This includes a group from the end of the 15C up to the middle of the 16C that attracts our attention : there were persons from the book trade who at the same time held the office of a messenger at the University of Paris. Although little of this double function is visible from historical sources, we can still see how the path they trod towards a reception of humanism looked like, even if only sketchily.
Quand la collaboration de recherche sert la légitimation d’un savoir d’expérience
Authors: Desgagné Serge , Larouche Hélène
Published: September 2021

Dans cet article, nous abordons la collaboration de recherche avec les enseignants en tant qu’elle peut constituer une entreprise de légitimation de leur savoir d’expérience. À titre d’illustration, nous refaisons le parcours d’un programme de recherche visant la constitution d’une banque de récits exemplaires de pratique enseignante destinés à être utilisés en formation, selon l’esprit de la méthode des cas. Dans l’évocation de ce parcours, nous analysons les enjeux de cette entreprise de légitimation à chacune des phases du programme de recherche, soit aux phases de reconstruction (phase 1), d’analyse (phase 2) et d’exploitation, en formation (phase 3), des récits exemplaires de pratique. Nous réservons un espace de réflexion privilégié à la troisième phase de légitimation en tant qu’elle constitue notre préoccupation actuelle de recherche. Nous y adressons la question de l’appropriation du savoir d’expérience par l’apprenti et du rôle médiateur que peut y jouer le récit exemplaire de pratique.
Analyse rétrospective de programmes de recherches collaboratives en langues modernes à l’Université de Liège
Authors: Beckers Jacqueline , Simons Germain
Published: September 2021

Cet article synthétise les résultats d’une étude visant à « revisiter » cinq programmes de recherches-actions menées par deux services de l’Université de Liège (Belgique) dans le domaine de l’enseignement/ apprentissage des langues étrangères à la lumière de deux éclairages théoriques distincts mais complémentaires. Le premier cadre théorique est celui des différentes étapes de la recherche collaborative (la cosituation, la coopération, la coproduction) proposées par Desgagné et al. (2001) ; le second est celui des genèses instrumentales, conceptuelles, identitaires (Pastré, 2005). Les cinq recherches collaboratives sont d’abord brièvement synthétisées. Ensuite, nous explicitons les fondements théoriques sous-jacents aux programmes de recherches collaboratives. Enfin, nous tentons d’établir des liens avec certains de nos programmes de recherches en nous basant sur les résultats d’une enquête réalisée auprès des professeurs-partenaires et des chercheurs.
Collaboration entre chercheur et acteurs : rôle de l’objet d’étude et de l’observatoire dans une approche « cours d’action »
Authors: Perrin Nicolas
Published: September 2021

Cette contribution interroge l’articulation entre recherche et formation au sein du programme empirique du « cours d’action ». Elle se focalise d’une part sur la définition de l’objet d’étude et d’autre part sur la nature de l’activité sollicitée par l’observatoire du « cours d’action ». L’observatoire du « cours d’action » (Theureau, 2006, 2009b) a pour but de renseigner l’activité des acteurs et consiste à les remettre en situation dynamique à l’aide de traces pour favoriser la verbalisation de la conscience préréflexive. Une distinction claire est alors opérée entre les verbalisations et les commentaires analytiques ou les prises de conscience. Cette distinction n’est toutefois pas évidente à tenir dans l’analyse d’une situation de formation. La réflexion porte sur les relations entre les conditions de collaboration et la définition progressive d’un objet de recherche, sur l’activité sollicitée par l’observatoire du « cours d’action » et les prises de conscience effectuées par les acteurs à cette occasion.
Le projet TBM : un exemple de modalité de collaboration entre chercheurs et praticiens en Norvège
Authors: Berg Claire Vaugelade
Published: September 2021

Cet article a un double objectif : d’abord offrir une description des principales caractéristiques d’un projet de recherche en cours en Norvège, ensuite, à l’aide d’un exemple, approfondir la relation entre le cadre méthodologique adopté dans notre projet et la pratique des enseignants. Cette recherche est ancrée dans un cadre théorique basé sur les notions de co-apprentissage et de communauté de pratique où la notion d’« inquiry » joue un rôle central. Les questions vives émergeant de ce projet sont présentées et discutées, en particulier la relation entre savoirs issus de l’expérience et savoirs issus de la recherche. Dans ce texte, nous utilisons le mot « inquiry » car sa traduction par le mot « enquête » est trop réductrice.
A Journey From Neural Networks to Deep Networks
Authors: Patel Priyanka P. , Thakkar Amit R.
Published: September 2021

The chapter is about deep learning fundaments and its recent trends. The chapter mentions many advanced applications and deep learning models and networks to easily solve those applications in a very smart way. Discussion of some techniques for computer vision problem and how to solve with deep learning approach are included. After taking fundamental knowledge of the background theory, one can create or solve applications. The current state-of-the-art of deep learning for education, healthcare, agriculture, industrial, organizations, and research and development applications are very fast growing. The chapter is about types of learning in a deep learning approach, what kind of data set one can be required, and what kind of hardware facility is required for the particular complex problem. For unsupervised learning problems, Deep learning algorithms have been designed, but in the same way Deep learning is also solving the supervised learning problems for a wide variety of tasks.
To Design a Mammogram Edge Detection Algorithm Using an Artificial Neural Network (ANN)
Authors: Aggarwal Alankrita , Chatha Deepak
Published: September 2021

An artificial neural network (ANN) is used to resolve problems related to complex scenarios and logical thinking. Nowadays, a cause for concern is the mortality rate among women due to cancer. Generally, women to around 45 years old are the most vulnerable to this disease. Early detection is the only hope for the patient to survive, otherwise it may reach an unrecoverable stage. Currently, there are numerous techniques available for the diagnosis of such diseases out of which mammography is the most trustworthy method for detecting early stage cancer. The analysis of these mammogram images is always difficult to analyze due to low contrast and non-uniform background. The mammogram images are scanned, digitized for processing, nut that further reduces the contrast between region of interest (ROI) and the background. Furthermore, presence of noise, glands, and muscles leads to background contrast variations. The boundaries of the suspected tumor area are always fuzzy and improper. The aim of this article is to develop a robust edge detection technique which works optimally on mammogram images to segment a tumor area.
A Proposal for Parameter-Free Surrogate Building Algorithm Using Artificial Neural Networks
Authors: Miriyala Srinivas Soumitri , Mitra Kishalay
Published: September 2021

Surrogate models, capable of emulating the robust first principle based models, facilitate the online implementation of computationally expensive industrial process optimization. However, the heuristic estimation of parameters governing the surrogate building often renders them erroneous or under-trained. Current work aims at presenting a novel parameter free surrogate building approach, specifically focusing on Artificial Neural Networks. The proposed algorithm implements Sobol sampling plan and intelligently designs the configuration of network with simultaneous estimation of optimal transfer function and training sample size to prevent overfitting and enabling maximum prediction accuracy. A novel Sample Size Determination algorithm based on a potential concept of hypercube sampling technique adds to the speed of surrogate building algorithm, thereby assuring faster convergence. Surrogates models for a highly nonlinear industrial sintering process constructed using the novel algorithm resulted in 7 times faster optimization.