bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on Flexural Behavior of Glass Fiber Reinforced Plastic Sandwich Composites Using Liquid Thermoplastic Resin
Authors: Alshahrani Hassan , Ahmed Azzam
Published: September 2022

Experimental and numerical studies of composite sandwich structures are warranted to reap the benefits of these materials when they are well designed. In the current research, new liquid thermoplastic and epoxy resins were used to fabricate four composite sandwich panels with two additional foam types and different densities in the wind turbine industry. A comprehensive comparison of three-point bending test results was made. Finite-element-based simulations using the ABAQUS program with Hashin’s damage criterion were conducted to examine the failure behavior of the GFRP sandwich composites. The flexural behavior of the glass-fiber-reinforced plastic (GFRP) sandwich panels was investigated and compared with the experiments. The results show that the GF/PVC/Elium composite panel gives the highest load absorption, flexural strength, flexural modulus, core shear ultimate strength, and facing stress due to effect of the core foam and resin types. For the PVC foam core sandwich panel, using thermoplastic resin increased the flexural strength by 18% compared to that of the epoxy resin. The simulation results show excellent agreement between the finite-element-predicted failure loads and the experimental results.
Analysis of the Behavior of Fiberglass Composite Panels in Contact with Water Subjected to Repeated Impacts
Authors: Omaña Lozada Anabelis Carolina , Arenas Reina José Manuel , Suárez-Bermejo Juan Carlos
Published: September 2022

One of the most common applications of glass fiber composite materials (GFRP) is the manufacturing of the hulls of high-speed boats. During navigation, the hull of these boats is subjected to repetitive impacts against the free surface of the water (slamming effect), which can cause severe damage to the material. To better understand the behavior of the composite material under this effect, in the present work, an experimental test has been carried out to reproduce the slamming phenomenon in GFRP panels by means of a novel device that allows this cyclic impact to be obtained while the panels are always in contact with water. By means of non-destructive ultrasound inspection in immersion, it has been possible to establish the evolution of the damage according to the number of impacts received by each panel. Destructive tests in the affected zone, specifically shear tests (Iosipescu test), allow determination of the loss of mechanical properties experienced by the material after receiving a high number of impacts in the presence of water (up to 900,000 impact cycles in some panels). The behavior of the material was found to be very different in wet and dry conditions. Under dry conditions, the material loses stiffness as the damage density increases and its shear strength also decreases, as does displacement at maximum load. For wet conditions, the material shows higher displacements at maximum load, while the shear strength decreases with increasing stiffness.
Effects of Accelerated Ageing by Humidity and Heat Cycles on the Quality of Bamboo
Authors: Jia Hao , Chen Lei , Fei Benhua , Sun Fengbo , Fang Changhua
Published: September 2022

The effect of humidity and heat environmental conditions on the durability of conventional bamboo materials is a pressing issue in the reserving phase of biomass materials. In this study, the relationship between the main physicochemical, pyrolytic, and mechanical properties of bamboo before and after ageing has been investigated. Exposure of engineered bamboo raw materials with moisture content up to 10% to alternating humidity and heat cycles (20 °C 98% RH-30 °C 64% RH-40 °C 30% RH) of ageing (HHT) causes degradation of the chemical polymer matrix. Byk Gardner 6840 color difference meter, X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), compression intensity, thermogravimetric-infrared spectroscopy (TG-IR), and density changes are used to assess the quality of the material before and after ageing. No significant changes in the moisture content within the range of 6.12 ± 0.327 after two weeks of the engineered bamboo during wet thermal cyclic ageing were determined. However, there were significant differences in mass loss (7.75–9.93 g), cellulose crystallinity, chemical changes, compression strength, and pyrolytic properties. Differences in specimen colors were observed during 10 weeks of the accelerated humidity heat cycling ageing, and TCD variations ranged from 3.75 to 20.08 and from 0.25 and 3.24, respectively. Reduced cellulose crystallinity (36.459–22.638%), axial compressive strength (63.07–88.09 MPa), and modulus of rupture (2409–4286 MPa) were found during aging, whereas deformation and ductility properties were improved. Both natural and humidity heat ageing improve thermal stability and peak pyrolysis rates (0.739–0.931; 0.731–0.797). Humidity heat cyclic ageing will assist in the design and risk assessment of warehousing environments for industrial applications.
Effect of Stacking Sequence on Long-Term Creep Performance of Pultruded GFRP Composites
Authors: Asyraf Muhammad Rizal Muhammad , Syamsir Agusril , Zahari Nazirul Mubin , Supian Abu Bakar Mohd , Usman Fathoni , Itam Zarina
Published: September 2022

Pultruded glass-fibre reinforced polymer (pGFRP) composites are classified as lightweight material, which exhibit high strength-to-weight ratio for structural usage. This composite material has been applied as cross-arm members in transmission towers due to its ability in thermal and electrical insulation. However, the influence of the stacking sequence of pGFRP composite on its mechanical performance has not been fully covered in the literature to explain the long-term durability of the current cross-arm designs. The study expected to evaluate five fiber layers with various stacking sequences in terms of quasi-static and creep tests in a four-point bending mode. The creep test was performed for 1440 h (60 days). These composites were fabricated using the pultrusion process in the form of a square hollow structure. Later, it was cut into composite coupons with various sizes depending on the test conducted. The results showed that nine layers with 0°/45°/0°/−45°/0°/−45°/0°/45°/0° had the ultimate flexural strength. This stacking sequence configurations seemed to be optimally manufactured in continuous roving fibre by alternating between 0° and ±45° fiber orientations. Additionally, the S-9 pGFRP composite sample showed that it had a low-creep deflection with high elastic and apparent creep moduli in 1440 h. In terms of strength reduction factor, this configuration was recorded as the highest. The findings showed that the nine layers of pGFRP composites with alternation of 0° and ±45° fiber orientations were highly suitable for structural application at transmission towers for a long-term operation.
Static Voltage Stability Assessment Using a Random UnderSampling Bagging BP Method
Authors: Zhu Zhujun , Zhang Pei , Liu Zhao , Wang Jian
Published: September 2022

The increase in demand and generator reaching reactive power limits may operate the power system in stressed conditions leading to voltage instability. Thus, the voltage stability assessment is essential for estimating the loadability margin of the power system. The grid operators urgently need a voltage stability assessment (VSA) method with high accuracy, fast response speed, and good scalability. The static VSA problem is defined as a regression problem. Moreover, an artificial neural network is constructed for online assessment of the regression problem. Firstly, the training sample set is obtained through scene simulation, power flow calculation, and local voltage stability index calculation; then, the class imbalance problem of the training samples is solved by the random under-sampling bagging (RUSBagging) method. Then, the mapping relationship between each feature and voltage stability is obtained by an artificial neural network. Finally, taking the modified IEEE39 node system as an example, by setting up four groups of methods for comparison, it is verified that the proposed method has a relatively ideal modeling speed and high accuracy, and can meet the requirements of power system voltage stability assessment.
Catalytic Oxidation of NO by Ozone over Mn-Ce/Al2O3/TiO2 Catalyst
Authors: Shen Hong , Tang Zijun , Xiao Xiang , Wu Haiwen , Zhou Hang , Fang Ping , Zhu Dingfang , Ge Jianhua
Published: September 2022

In this study, Mn-Ce/Al2O3/TiO2 catalyst prepared by impregnation method was used for synergistic O3 oxidation NO. The catalyst prepared by impregnating Al2O3/TiO2 at a Mn:Ce molar ratio of 4:1 showed the best catalytic activity. The catalyst performance showed that when the molar ratio of Mn:Ce was 4:1 and the volume ratio of O3:NO was 1:4, the removal rate of NO could reach 63%, which could increase the removal rate by 40% compared with that of NO oxidized by O3 alone. BET, XRD, and TEM characterization results showed that when the molar ratio of Mn:Ce was 4:1, the catalyst specific surface area, and pore capacity were the largest. A large amount of MnOx and CeOx were distributed on the catalyst surface. The XPS analysis showed that the oxidation-reduction and oxygen vacancy of Mn (IV)/Mn (III)/Mn (II) and Ce (IV)/Ce (III), had a synergistic effect on the decomposition of O3 into reactive oxygen species(O*), thus improving the catalytic capacity of Mn-Ce/Al2O3/TiO2 catalyst for O3. The O2-TPD analysis showed that the oxygen vacancies and oxygen species in the catalyst could be used as the active point of decomposition of O3 into O*. The experimental results show that the prepared catalyst can significantly improve the efficiency of ozone oxidation of NO and reduce the amount of ozone. The catalyst can be applied to ozone oxidation denitrification technology.
Spread of SARS-CoV-2 Infections in Educational Settings by Level of Education, Taking into Account the Predominant Virus Variant
Authors: Galičič An , Kranjec Natalija , Rožanec Jan , Obid Ivana , Grilc Eva , Gabrovec Branko , Fafangel Mario
Published: September 2022

The COVID-19 pandemic has negatively affected educational settings (ES) in Slovenia. To effectively limit the emergence and spread of SARS-CoV-2 infections in ES, it is important to identify the pathways of introduction and transmission of infection. This study aims to analyse the spread of infections in ES according to the level of education, taking into account the predominant variant of the virus in Slovenia in order to advise on public health action. We calculated the incidence rate of infection by age group, according to the level of the ES. Additionally, we analysed data on the reported outbreak criteria in ES. In Slovenia, SARS-CoV-2 infections in children and adolescents (1–18 years) accounted for 16.8% of all confirmed infections. The incidence and leading outbreak criteria differed according to the level of the ES and predominant SARS-CoV-2 variant. The occurrence of cases in ≥3 different “bubbles” was the most common outbreak criteria (59%). A high number of employee-imported outbreaks was observed in pre-school settings (44%). As countries move away from widespread nonpharmaceutical interventions, the focus should be on vaccination promotion among teaching staff in pre-school settings and systemic solutions, such as self-testing and ventilation, to enable safe educational environments.
Comparison of IoT Communication Protocols Using Anomaly Detection with Security Assessments of Smart Devices
Authors: Bhardwaj Akashdeep , Kaushik Keshav , Bharany Salil , Elnaggar Mohamed F. , Mossad Mohamed I. , Kamel Salah
Published: September 2022

The authors implemented an attack scenario that involved simulating attacks to compromise node and sensor data. This research proposes a framework with algorithms that generates automated malicious commands which conform to device protocol standards and bypass compromise detection. The authors performed attack-detection testing with three different home setup simulations and referred to Accuracy of Detection, Ease of Precision, and Attack Recall, with the F1-Score as the parameter. The results obtained for anomaly detection of IoT logs and messages used K-Nearest Neighbor, Multilayer Perceptron, Logistic Regression, Random Forest, and linear Support Vector Classifier models. The attack results presented false-positive responses with and without the proposed framework and false-negative responses for different models. This research calculated Precision, Accuracy, F1-Score, and Recall as attack-detection performance models. Finally, the authors evaluated the performance of the proposed IoT communication protocol attack framework by evaluating a range of anomalies and compared them with the maliciously generated log messages. IoT Home #1 results in which the model involving an IP Camera and NAS device traffic displayed 97.7% Accuracy, 96.54% Precision, 97.29% Recall, and 96.88% F1-Score. This demonstrated that the model classified the Home #1 dataset consistently.
Numerical Simulation Study on the Flow Properties of Materials for Plugging While Drilling in MWD
Authors: Pu Lei , Xu Peng , Xu Mingbiao , Zhou Jun , Liu Qinglin , Song Jianjian
Published: September 2022

The method of plugging while drilling has been one of the commonly used methods to control formation loss during drilling. The damage to materials for plugging while drilling to MWD has become a complex problem. For many years, field engineers had insufficient knowledge of the passing performance of materials for plugging while drilling in measurement while drilling (MWD). In the existing research, the blocking mechanism of materials for plugging while drilling to mud screen during the flow process is still unclear. In this study, we use computational fluid dynamics coupled with discrete element method (CFD–DEM) to investigate materials’ plugging mechanism while drilling. The results show that the migration process of lost circulation materials (LCMs) in the mud screen can be divided into three stages, displacement, retention, and accumulation of LCMs. The blocking mechanism of LCMs on the mud screen comes from two aspects. One is from the bridging of LCMs with larger particle size in the holes of the mud screen. Another source is the difference between the entry speed and the overflow speed of LCMs. The particle size and mass fraction of LCMs and the viscosity and displacement of the fluid affect the flow properties of LCMs from these two factors, respectively.
Landslide Susceptibility Modeling Using Remote Sensing Data and Random SubSpace-Based Functional Tree Classifier
Authors: Peng Tao , Chen Yunzhi , Chen Wei
Published: September 2022

In this study, a random subspace-based function tree (RSFT) was developed for landslide susceptibility modeling, and by comparing with a bagging-based function tree (BFT), classification regression tree (CART), and Naïve-Bayes tree (NBTree) Classifier, to judge the performance difference between the hybrid model and the single models. In the first step, according to the characteristics of the geological environment and previous literature, 12 landslide conditioning factors were selected, including aspect, slope, profile curvature, plan curvature, elevation, topographic wetness index (TWI), lithology, and normalized difference vegetation index (NDVI), land use, soil, distance to river and distance to the road. Secondly, 328 historical landslides were randomly divided into a training group and a validation group in a ratio of 70/30, and the important analysis of landslide points and conditional factors was carried out using the functional tree (FT) model. In the third step, all data are loaded into FT, RSFT, BFT, CART, and NBTree models for the generation of landslide susceptibility maps (LSM). Comparisons were made by the area under the receiver operating characteristic curve (AUC) to determine efficiency and effectiveness. According to the verification results, the five models selected this time all perform reasonably, but the RSFT model has the highest prediction rate (AUC = 0.838), which is better than the other three single machine learning models. The results of this study also demonstrated that the hybrid model generally improves the predictive power of the benchmark landslide susceptibility models.
Tri-Reagent Homogenate Is a Suitable Starting Material for UHPLC-MS Lipidomic Analysis
Authors: Fresnedo Olatz , Abad-Garcia Beatriz , Rueda Yuri
Published: September 2022

Background: Transcriptomic and lipidomic dual analyses usually initiate with independent extractive procedures. That entails a difficulty in aligning results from both omics platforms, especially in the case of highly heterogeneous tissues, such as the kidney. Methods: Bligh and Dyer lipid extraction was performed using rat kidney homogenates prepared in PBS or commercially available Tri-reagent used for RNA extraction. Samples were analyzed by ultrahigh performance liquid chromatography-mass spectrometry (UHPLC-MS) lipidomic analysis. Results: Comparison of the lipidome obtained from phosphate-buffered saline (PBS) and Tri-reagent homogenates showed qualitative and quantitative validity of the Tri-reagent homogenate with the exception of ether lipids; the acidic nature of the mix seems to promote the hydrolysis of the ether bond, especially in plasmalogens. We tested several conditions in the sample processing, which allowed to optimize the procedure. Conclusions: Aiming to implement a method that allows the extraction of RNA and lipids from the same tissue homogenate not using external tracers, we here report the use of Tri-reagent homogenates as a suitable starting material for UHPLC-MS lipidomic analysis.
Health Care in Cities Perceived as Smart in the Context of Population Aging—A Record from Poland
Authors: Jonek-Kowalska Izabela
Published: September 2022

Population aging is a global problem affecting many modern economies. Thus, the article attempts to answer the following research questions: What demographic trends characterize cities considered smart, and is the health care offered by these cities adapted to the changes identified in this regard? In other words, can seniors feel safe now and in the near future? In search of an answer to such a question, data as well as demographic and health indicators were used from 16 Polish voivodeship cities mostly considered smart or aspiring to that title. The analysis covered the years 2010–2020. The results indicate a systematic aging of all surveyed urban communities. However, it is progressing at a rather different pace. Unfortunately, not all cities are adjusting the level of health care (medical and nursing staff and hospital infrastructure) to the needs of the growing number of seniors, which—in the future—may exacerbate regional and local medical and social problems. The analysis also shows that the best-performing cities in terms of health care development are Warsaw, Białystok, Kraków and Rzeszów—the units most often identified in international rankings as smart. Their “smartness” in this case lies in forward-looking management that takes into account the aging of the urban community in the process of developing medical care.
Real practice and work prospects of a clinical pharmacologist in an oncology dispensary
Authors:   SBHI Samara Regional Clinical Oncology Dispensary, FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, Paravina E. V.
Published: September 2022

On May 5, 1997, the order of the Ministry of Health of Russia No. 131 «On the Introduction of Clinical Pharmacology Major» entered into force. For a short period, clinical pharmacology has become not only an academic discipline and a scientific major, but one of the most sought-after applied areas. The World Health Organization has defined the main goal of clinical pharmacology as a practical major: «Improving patients’ health by increasing safe and effective use of medications». The clinical pharmacology service of the dispensary fully participates and plays one of the main roles in the process of ensuring the drug safety of a medical organization.
Nialamide in the treatment of depressive states
Authors:   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Mashkovskaya M. A. , Maksimov M. L. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow
Published: September 2022

Depression is a mental disorder manifested by depressed mood, cognitive and motor retardation, and suicidal ideas. In the modern world, the number of cases of a combination of mental and somatic pathologies is increasing in medical practice. Therefore, the issue of studying and correctly prescribing antidepressants is crucial. It is necessary that the drug should not only treat the mental illness of the patient, but also should not harm his/her physical health. Nialamide belongs to antidepressants, the mechanism of which is non-selective and irreversible inhibition of MAO-A and MAO-B.
On pharmacotherapy of chronic tonsillopharyngitis
Authors:   FSBEI HE Rostov State Medical University, Rostov-on-Don, Meloyan E. K.
Published: September 2022

Purpose of the study: to evaluate the pharmacological activity of 1,3‑diethylbenzimidazolium triiodide in the treatment of chronic compensated tonsillopharyngitis.
Selected pharmacological effects of glycine
Authors:   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Chupakhina Е. , Maksimov M. L. ,   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow
Published: September 2022

Glycine is an aliphatic non-essential amino acid that performs a number of very diverse functions, forms part of proteins and such vital substances as collagen and glutathione, participates in the synthesis of heme porphyrin rings and nucleic acids, and performs the function of an inhibitory neurotransmitter in the central nervous system.
Survey of Sars-Cov-2 Genetic Material Reduction During a Traditional Wastewater Treatment Technology
Authors: Adamcsik Orsolya , Gerencsér-Berta Renáta , Oláhné Horváth Borbála , Kovács Nikoletta , Somogyi Viola , Domokos Endre Gábor , Kemenesi Gábor , Tóth Endre Gábor , Jakab Ferenc , Galambos Ildikó
Published: September 2022

The transmission of Severe Acute Respiratory Syndrome Coronavirus-2 in a community can be monitored by a wastewater-based epidemiological approach due to fecal shedding. Although sewage surveillance has gained a considerable amount of attention over the last 16 months, an indirect issue within the topic is whether traditional wastewater treatment technologies are sufficiently efficient to eliminate the genetic material of SARS-CoV-2. Samples were taken from the Wastewater Treatment Plant in Nagykanizsa before the virus was concentrated, nucleic acid extracted and SARS-CoV-2 detected by RT-qPCR (Quantitative reverse transcription PCR). The influent and primary treated samples tested positive, while after the secondary treatment, all the results were negative. Consequently, the activated sludge process proved to be efficient in terms of the removal of SARS-CoV-2.
Membrane Unit for Integrated Gas Separation – Membrane Bioreactor (GS-MBR) System
Authors: Pientka Zbyněk , Peter Jakub , Válek Robert
Published: September 2022

One of the research directions of renewable energy sources is the production of biohydrogen from the dark fermentation of organic matter. During this fermentation process, since hydrogen is produced along with a complex mixture of other gases and vapors, hydrogen gas requires further purification. One relatively easy solution to this problem might be the utilization of gas separation membrane modules given their low energy consumption, simple operation and ease of upscaling. In this work, hollow fiber (HF) membranes based on polyetherimide (PEI) were developed and tested. HF membranes were spun from a polymer solution of PEI using the wet phase inversion process into a water bath using a pilot-scale spinning device. Gas transport measurements showed that membranes exhibited permeances of between 9.3 and 19.2 GPU with CO2/H2 selectivities within the range of 3.3 - 5.6. Morphology studies showed regular shapes resembling hollow fibers with outer diameters within the range of 250-320 microns, depending on various parameters of the spinning process. The best performing membranes were selected and a morphological analysis carried out. Selected fibers were incorporated into two types of membrane modules. One type was a laboratory-scale membrane mini-module used for preliminary tests, while the other membrane module was designed for the treatment of larger amounts of biohydrogen. Two types of laboratory-scale membrane separation units were constructed. For laboratory use, the low-pressure unit proved more accurate regulation to match the fermenters performance with the separation unit in comparison with the high-pressure one.
IMPACT OF THE GENE EXPRESSION LEVEL AND INTERMOLECULAR INTERACTION NETWORKS ON RADIORESISTANCE OF TUMOR CELLS
Authors: Pogodina Evgeniya Sergeevna , Rastorgueva Evgeniya Vladimirovna , Yurova Elena Valer'evna , Beloborodov Evgeniy Alekseevich , Sugak Dmitriy Evgen'evich , Saenko Yuriy Vladimirovich , Fomin Aleksandr Nikolaevich , Volkov Maksim Anatol'evich , Kostishko Boris Mikhaylovich
Published: September 2022

Despite its efficacy, radiation therapy faces the challenges connected with accelerated reproduction of tumor cells and radioresistance of malignant neoplasms.
The aim of the study was to analyze the impact of the gene expression level and intermolecular interaction networks on the development of tumor cell radioresistance.
Materials and Methods. The authors used 4 tumor cell lines: (K562, HCT-116p53 (+/+), HCT-116p53 (–/–), and Me45. To study the cell line transcriptome. Affymetrix high-density hybridization DNA chips (HGU133A series) were used. Bioinformatic analysis of gene expression dynamics was performed using the original Gene Selector program. Intermolecular interaction networks were studied using the STRING online system.
Results. After exposure to ionizing radiation at a dose of 4 Gy, the expression level of DAAM1, IFNAR2, PALLD, and STK17A genes increases in K562 cell line and decreases in HCT-116p53 (+/+), HCT-116p53 (–/–) and Me45. Numerous protein complexes of the studied genes were found with STRING online system. Thus, DAAM1, IFNAR2, PALLD, and STK17A genes influence the activity of some particles in the network of intermolecular interactions. Selected DAAM1, IFNAR2, PALLD and STK17A genes and protein-protein complexes encoded by DAAM1, TNK2, PTBP2 and DVL2; IFNAR2, STAT2, IRF9, JAK1, GNB2L1 and IFNAR1; PALLD, LPP and ACTN2 genes can be used as potential targets. Their modulation can increase the response of malignant neoplasm cells to ionizing radiation.
CHRONIC KIDNEY DISEASE IN PATIENTS WITH CHRONIC LYMPHATIC LEUKEMIA AND THEIR SURVIVABILITY
Authors: Markovtseva Mariya Vladimirovna , Zgural'skaya Ekaterina Nikolaevna
Published: September 2022

Chronic lymphocytic leukemia (CLL) is one of the most common lymphoproliferative diseases in the European population with an increase in the incidence in the elderly and senile age. However, it is among the elderly that a decrease in glomerular filtration rate (GFR) and concomitant chronic kidney disease (CKD) are associated with the severity in long-term prognosis.
The aim of the study was to analyze CKD incidence and prognostic value in patients with CLL.
Materials and Methods. CLL retrospective analysis was performed in 132 patients (60 men and 72 women). CKD was diagnosed according to the 2021-Guidelines of Russian Scientific Society of Nephrologists. Results. Among the examined patients, 64 (48.5 %) were diagnosed with CKD: stage C2 – in 23 patients. (17.4 %), stage C3a – in 41 patients. (31.1 %). CKD incidence in patients with CLL was higher than in the similar population without CLL. The authors revealed that there was no correlation between CLL stage and CKD severity. Survival analysis showed that only 43 patients (32.5 %) overcame the estimated Binet median survival. C3a in patients with CLL at the time of CKD diagnosis is strongly correlated with survival.
Conclusion. CKD occurs in 48.5 % of patients with CLL. It has been established that C3a CKD worsens CLL patient survivability.
PHENOTYPIC CHARACTERISTICS OF ANDROGEN RECEPTOR-POSITIVE CANCER IN THE TRIPLE-NEGATIVE BREAST CANCER GROUP
Authors: Panchenko Ivan Sergeevich , Rodionov Valery Vitalievich , Panchenko Sergey Viktorovich , Sharafutdinov Marat Gakifovich
Published: September 2022

The aim of the paper is to reveal the phenotypic characteristics of androgen-receptor-positive breast cancer in triple-negative breast cancer.
Materials and Methods. The authors analyzed clinical and morphological tumour data in 253 patients with morphologically verified invasive triple-negative breast cancer (TNBC). The patients were treated at the Regional Clinical Oncologic Dispensary (Ulyanovsk) and the Breast Pathology Department of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov (Moscow) from 2014 to 2021.
Results. Statistical analysis of 45 patients (18 % of the total sample) showed that androgen receptor (AR) expression in TNBC was observed in patients older than 61 years (p=0.054). It was associated with a more common stage of the disease (starting with IIB) (p=0.004), multifocal growth pattern (p=0.025), invasive lobular cancer (p=0.04), higher tumor differentiation (p<0.0001), low Ki67 level (p=0.000001), and more frequent involvement of regional lymph nodes (p=0.005). At the same time, there were no statistically significant correlations between the AR expression and menstrual function, breast lesion quadrant, and pathomorphological response after neoadjuvant polychemotherapy.
Conclusion. AR expression in TNBC occurs in patients over 61 years of age, with a locally advanced disease stage, a multifocal tumor growth pattern, an invasive lobular cancer, and well-differentiated tumors with low proliferative activity.
HOMOCYSTEINE LEVELS IN WOMEN WITH SYMPTOMATIC UTERINE FIBROIDS
Authors: Sidorova Yuliya Dmitrievna , Davidyan Liana Yur'evna , Bogdasarov Azat Yur'evich
Published: September 2022

Uterine fibroids are considered one of the most common benign tumors of the reproductive system. This disease ranks second (20–50 %) among the causes of hospitalization in gynecological hospitals.
The aim of the study is to evaluate the effect of homocysteine levels on the state of uterine fibroids.
Materials and Methods. The study involved 112 women: 60 with uterine fibroids and 52 without uterine fibroids. General clinical, biochemical, ultrasound, and statistical research methods were used. Mathematical data processing was carried out according to Lang T. and Altman D. (2014). Quantitative data analysis on the normality of distribution was carried out using the Shapiro-Wilk test.
Results. The normal homocysteine (Hc) level was found in 80.7 (5.5) % of patients without uterine fibroids, which is statistically more significant than in the group of women with uterine myoma (38.3 (6.3) %, p<0.001). HC level was at the upper normal level in 33.3 (6.1) % of women in the main group and 15.3 (5.0) % of women in the comparison group. An excess of normal values was found in 25.0 (5.6) % of women in the main group and only in one in the comparison group (p<0.001). Due to additional therapy of uterine fibroids, the state of myomatous nodes stabilized in 61.6 (6.3) % of patients. There was no progression of uterine fibroids during a year. Before complex therapy, surgical indications were in 25.0 (5.6) % of patients with uterine fibroids. After a year of complex therapy, surgical indications remained only in 6.6 (3.3) % of women with uterine fibroids, which is statistically less significant than before the prescribed treatment (p=0.005).
Conclusion. In women with uterine fibroids, there are multiple genital and somatic pathologies that contribute to the increase of Hc level and the development of uterine fibroids.
The use of folic acid and B-group vitamins in addition to the clinical protocol for the treatment of uterine fibroids made it possible to stabilize the myomatous nodes and reduce surgical treatment by 4 times.
DISTURBANCE OF PRO-OXIDANT-ANTIOXIDANT BALANCE IN RATS WITH CEREBRAL ISCHEMIA
Authors: Bon' Elizaveta Igorevna , Maksimovich Nataliya Evgen'evna , Dremza Iosif Karlovich , Nosovich Miroslav Alekseevich , Khrapovitskaya Kseniya Aleksandrovna
Published: September 2022

Excess of reactive oxygen can lead to membrane damage, accumulation of lipid, protein, and nucleic acid oxidation products, deficiency of reduced pyridine nucleotides and phospholipids of mitochondrial membranes, and then to electrolyte imbalance, mitochondrial swelling, uncoupling of oxidation and phosphorylation processes, and ischemic neuronal death. Thus, the study of oxidative stress and antioxidant system activity is relevant.
The aim of the study is to examine the changes in the pro-oxidant-antioxidant balance in rats with ischemic brain damage of different degrees of severity (subtotal and total cerebral ischemia).
Materials and Methods. The experiments were performed on 30 male outbred white rats weighing 260±20 g in compliance with the requirements of the Directive of the European Parliament and the Council of the European Union No. 2010/63/EU of September 22, 2010 on the protection of animals used for scientific purposes.
Results. A more significant decrease in the content of total SH-groups of proteins and glutathione (by 58 (51; 64) % (p<0.05)), and GSH concentration (by 29 (19; 35) % (p<0.05)) was observed under 24-hour subtotal brain ischemia (SBI) compared with 1-hour SBI. Changes in the glutathione peroxidase activity were multidirectional: in 1-hour SBI, the activity increased by 12 (9; 18) % (p<0.05compared to the control level, and in 24-hour SBI, it decreased by 74 (67; 81) % (p<0.05). In 1-hour SBI, the content of total SH-groups of proteins and glutathione was higher by 60 (54; 65) % (p<0.05), and GSH concentration was higher by 42 (39; 56) % (p<0.05) compared with 1-hour total brain ischemia (TBI). The content of products that react with thiobarbituric acid increased by 59 (51; 63) % (p<0.05). In 24-hout SBI, the content of total SH-groups of proteins and glutathione was higher by 36 (29; 45) % (p<0.05), and GSH concentration was higher by 63 (59; 75) % (p<0.05) compared with 24-hour TBI. The content of products that react with thiobarbituric acid increased by 83 (78; 91) % (p<0.05). The glutathione peroxidase activity in TBI was equal to zero.
Conclusions. Thus, the most pronounced disturbances in the pro-oxidant-antioxidant balance were observed in 24-hour TBI. Similar, but less pronounced disturbances were observed in 24-hour SBI.
THE LYRICS OF ANATOLY GULAK: ABOUT THE AUTHOR'S POTENTIAL SPEECH THINKING
Authors: Зайцева I. П.
Published: September 2022

The article is devoted to the identification and analysis of a number of linguo-stylistic and linguo-aesthetic characteristics inherent in the lyric texts of the poet Anatoly Gulak, which, as it seems, most clearly embody the features of the poetic speech thinking of their creator.This analysis is preceded by a brief examination of the phenomenon of poetic speech thinking – the creative intellectual activity of the artist of the word, which is actively comprehended at the present time not only by philology, but also by fields adjacent to philological science (psychopoetics, psychology of artistic creativity, etc.) in various aspects, as well as by the characteristic one of its types: seminal-seminal, actualizing the ability of the word to desemantizeandto acquire additional semes in a poetic context, including occasional-figurative properties. This type of poetic speech thinking, according to our observations, is most often embodied in the lyric work of A. Gulak, is illustrated by material from the poets poems (the cycle “Rainbow over the forest”), the generalization of the features of which made it possible to establish some individual stylistic features of the author’s manner. The analysis shows the priority importance in the lyrics of A. Gulak of tropes that are distinguished by a special character – syncretic in their essence: in the tropical constructions of the poet’s lyric works, metaphor and epithet, metaphor and comparison, comparison and epithet are combined. It is the functioning of this kind of tropes that largely ensures, from our point of view, the uniqueness of the individual author’s handwriting of A. Gulak, at the same time giving the verbal fabric of his works originality and uniqueness. The most interesting for consideration are tropes with a component – an artistic comparison, which are quite rare in modern poetry. Syncretic paths perform another important function in the poet’s works – compositional and aesthetic, during the implementation of which not only the linguistic material attracted by the author is organized into an integral semantic-associative system, but also the subtext layer of the lyrical structure is significantly deepened and expanded.
Pengrajin Batik PakisAji Malang
Authors: Pirmaningsih Lilik , Bararoh Tantri , Kholidiah
Published: September 2022

Kegiatan Pengabdian Masyarakat ini ditujukan kepada pengrajin batik di Kecamatan Pakisaji Kabupaten Malang. Di wilayah ini banyak masyarakat yang menekuni pembuatan batik secara tradisional untuk dijual di berbagai daerah. Selama ini belum membuat laporan keuangan karena keterbatasan kemampuan dan pengetahuan tentang cara Menyusun laporan keuangan. Selain itu mereka belum menyadari pentingnya informasi yang diperoleh dari pelaporan keuangan. Oleh karena itu pengabdian masyarakat ini berusaha untuk memberikan solusi dalam menyusun laporan keuangan sederhana yang dapat digunakan untuk mengetahui keberlangsungan usahanya, untuk mengetahui keberhasilan usahanya, untuk pertimbangan pengambilan keputusan perluasan usaha, penambahan dana, dan keputusan yang lainnya. Metode pengabdian masyarakat yang dipakai adalah pendampingan. Pendampingan dilakukan dengan membantu dan terlibat dalam proses penyusunan laporan keuangan sederhana kepada para pengrajin batik di kecamatan pakisaji. Hasil dari kegiatan pengabdian masyarakat ini berupa draft laporan keuangan sederhana untuk para pengrajin batik.
Matrimony and parenthood in the life of Queen Victoria
Authors: Warowny Wojciech
Published: September 2022

Starting a family and caring for your offspring is a task of a paramount importance in the life of every person. This belief is unchangeable since the ages past and was popular also in 19th  century, when love was not the most important virtue in marriage and childrens’ mortality rate was maintaining a very substantial number. The person who knew it the best was „the Grandmother of Europe” – Queen Victoria who, together with her husband, prince Albert, fostered nine children, and her descendants to this day reign over some of the thrones of Europe.

In this article the mindset of Queen Victoria, in regards to parenthood, will be shown on the basis of journals and her correspondences. Motherhood was a „darker side” of marriage. In that century It was a duty of every woman to fulfill it. High number of pregnancies and problems with properly fostering a family, left a physical and mental mark on Victoria, which is why her view on upbringing may surprise and shock.

Relationship of Victoria and Albert was not as harmonious as people thought, because of couple’s differences in character. Rashness and short temper of Victoria fought Albert’s calmness and mindfulness – that was the picture of their married life for over 20 years. Numerous rows and arguments were a constant element of their life. On the one hand feeling of being intellectually inferior, on the other, low social status, those were the main reasons for disagreements between spouses. During their marriage Albert tried to change Victoria’s character. To some extend he succeeded, but the price was his health. The picture of the royal family perceived by their people was different to reality, but warmth and joy of family life, without disagreements and maintaining all moral codes, were supposed to be a trademark of family in Victorian era.
Satisfaction of life in postmenopausal women
Authors: Pałucka Klaudia , Bałanda-Bałdyga Agnieszka , Kęsik Jan Jakub , Pilewska-Kozak Anna B.
Published: September 2022

Introduction: Experiencing life satisfaction is an undisputed human desire. The postmenopausal period usually entails certain ailments that may contribute to the weakening of the woman's psychophysical condition and thus satisfaction with life.Aim of the study: The aim of the study was to examine the life satisfaction of postmenopausal women.

Material and methods: The research was carried out in six randomly selected gynaecological clinics and in primary care clinics in the city of Lublin. They included 510 women. A diagnostic survey was used as a test method. The research tool was a questionnaire specially prepared for this work, consisting of sociodemographic data and a standardized questionnaire Satisfaction with Life Scale.

 Conclusions: Postmenopausal women are characterized by average life satisfaction. There is a relationship between life satisfaction and the level of education, subjective assessment of the material and housing situation, subjective assessment of health and sexual activity.

Keywords: menopause, postmenopause, life satisfaction
Motives for selected crimes against life and health
Authors: Woźniak Waldemar
Published: September 2022

Criminal behavior undermines both social and individual security. Exploring the motivational process in criminal acts focuses on searching for the sources of these acts and determining the factors that sustain criminal activity. Crime is not a homogeneous phenomenon, which makes the motives for crime diverse and complex.

Criminological theories explore the causal factors of crime such as biological (including genetic), sociological (social), and psychological. A criminal act can be caused by an unformed drive, frustration, and be learned, including through following others. In the process of determining the motives for criminal behavior, it is not enough to point to direct motives because motivation should be approached as a process, which indicates the possibility of the development of motives over a certain time, and even many years. Thus, it is necessary to take into account socialization, personality traits (the level of aggressiveness, directiveness, and dominance), psychological needs (especially those unmet), and values, which, in a sense of responsibility, often can be considered anti-values.

The major crimes against health and life are homicide, fights, and battery. In addition to ordinary murder, the Polish Penal Code lists aggravated murder (e.g., with extraordinary cruelty or as a result of motives deserving special condemnation) and privileged murder (committed under the influence of strong agitation justified by the circumstances), which can also be referred to as murder of passion. Fights and battery can be committed with or without the use of a dangerous object.

A review of the literature indicates the following motives for homicide: robbery (economic), sexual, emotional, delusional, revenge, threat, insult, sense of harm, and jealousy. Perpetrators of fights and battery may be characterized by component factors of antisocial personality disorder as specified by DSM-5, such as non-compliance with legal and social norms, impulsivity, irritability, aggression, irresponsibility, and lack of guilt.

In the case of crimes against life and health, it seems reasonable to identify several motives for the act. Motives are assessed primarily by a clinical interview. However, it should be taken into account that the perpetrators of these acts, for a variety of reasons, may obstruct justice.
The contexts of mask. On another note to the considerations of Rev. Edward Wojtusiak on the social uniform
Authors: Domański Cezary
Published: September 2022

Forty years ago the Kultura i Społeczeństwo magazine published a sociological essay by Reverend Edward Wojtusiak (1905-1983) on the subject of "social uniform". It contains reflections on the shaping of human social personality, inspired by the views of Józef Chałasiński. The concept of social uniform refers to those concepts perceiving social life as if it were a drama staged in a theater. The leading topic of the essay is a multifaceted presentation of the issues of "mask" in formal and material terms, as a concept used by psychologists, philosophers, sociologists and practitioners to explain various aspects of human expression in social contacts. The views of classics such as Richard Müller-Freienfels, Karl Jaspers, Otto Tumlirz, Ludwig Klages, Paul Guillaume, Ernst Harms and Carl Gustav Jung were used. Referring to the aforementioned theatrical metaphor, we can assume that in the most general approach to the subject, a mask is understood as a sign or a system of signs communicating various aspects of human personality "on the stage of life". Due to the current pandemic situation, the concept of mask, previously functioning mainly as a term of theoretical considerations, has been supplemented with a number of new meanings related to its universality and the necessity to use it in various situations of our everyday life. This includes, among other things, its impact on interpersonal communication and the relationship with the expression of extreme attitudes towards epidemiological threats, manifested by putting on or refusing to wear a mask in public places. The article presents the results of selected psychological studies from 2020-2021 on the impact of wearing masks on reading emotions from facial expressions, and confronts the applicability of classic mask theories in explaining and searching for new research aspects for this content-relevant construct in the field of social sciences. Rich in content the essay by Rev. Edward Wojtusiak seems to be a good starting point for the exploration of the issue, and the upcoming anniversary of its publication prompts us to refer to this text.
Ancestral Christology vis-à-vis Postmodernism
Authors: Wanjohi Jackson N. , Kiboi John M.
Published: September 2022

Recent theological trends among, African theologians have advocated for theological reflection on the Christian faith in the light of the African socio-cultural milieu. Certainly, there are obvious challenges that always goes with contextual theologies. For instance, African Christology, a theology centred on the study of Christ from an African perspective and which is born out of this approach, has given birth to Ancestral Christology. The challenge facing this type of Christology is that most of the so-called postmodern Africans do not have adequate knowledge of cultural elements and do not appear to appreciate this indigenous rooted christology. This research article seeks to clarify Ancestral Christology, as espoused by Charles Nyamiti and Benezet Bujo in the context of Postmodern Africa, and evaluates its impact on the spirituality of postmodern people. It moves on to construct a Reconstructive Guest Christology, from a socio-cultural perspective, as a methodology in constructing African Ancestral Christology. The Reconstructive Guest Christology portrays Christ as the one who reconstructs lives at individual, cultural, social-economic, liturgical, structural, communal, and at the universal levels. To this end, it strives to restore wholeness, lost dignity, spiritual justice, fairness, and reconciliation through love which are central to Jesus’ solidarity with humanity. It is hoped that this would appeal to postmodernists as they participate in Christ’s divine providence. The material in this article is conceptually and methodologically designed and gathered through an extensive review of relevant literature.