bluuebunny/crossref_metadata_2025 huggingface dataset:
Data-Driven Computer Choreography Based on Kinect and 3D Technology
Authors: Ma Muyuan , Sun Shan , Gao Yang
Published: January 2022

As a form of artistic expression, dance accompanied by music enriches the cultural life of human beings and stimulates the creative enthusiasm of the public. Choreography is usually done by professional choreographers. It is highly professional and time-consuming. The development of technology is changing the way of artistic creation. The development of motion capture technology and artificial intelligence makes computer-based automatic choreography possible. This paper proposes a method of music choreography based on deep learning. First, we use Kinect to extract and filter actions and get actions with high authenticity and continuity. Then, based on the constant Q transformation, the overall note density and beats per minute (BPM) of the target music are extracted, and preliminary matching is performed with features such as action speed and spatiality, and then, the local features of the music and action segments based on rhythm and intensity are matched. The experimental results show that the method proposed in this paper can effectively synthesize dance movements. The speed and other characteristics of each movement segment in the synthesis result are very uniform, and the overall choreography is more aesthetic.
Safety Assessment of Ship Collision with Piers under the Protection of Anti‐Collision Floating Box Based on BIM Technology
Authors: Chen Ying-hao , Liu Cheng , Zhao Xue-feng , Li Fa-xiong
Published: January 2022

In order to research the force state of the piers subjected to a ship collision under the protection of floating anti‐collision facilities, this study uses nonlinear spring connections to simulate the impact of ship damping and incidental water quality in the collision area. BIM technology is used to realize a safety evaluation method for the anti‐collision floating box protection when the ship is colliding with piers. Established a BIM‐based parametric preprocessing model for ships, piers, and anti‐collision facilities, and opened the interface with ABAQUS longitudinally. After realizing the parameter adjustment of the BIM model, the visual parameter adjustment can be realized without destroying the boundary conditions, load conditions, and meshing. Taking a rigid frame bridge as an example, the most disadvantage position of the bridge pier under ship collision is determined by the parameterization method. At the same time, multi‐condition analysis was carried out on the ship impacting the pier anti‐collision floating box at different angles, different tonnages, and different speeds. Finally, the analysis results are traced back to the BIM model, achieving the unified integration of BIM model information and finite element analysis results and the purpose of visual analysis of any working conditions. The results show that the use of BIM parameterization technology to achieve linkage with the finite element preprocessing model can improve the efficiency of multi‐condition sensitivity analysis and achieve the purpose of visual dynamic adjustment. The safety assessment analysis of the pier under the protection of the anti‐collision pontoon on the pier under various working conditions shows that the anti‐collision pontoon effectively reduces the hazard of the ship colliding with the pier, and the impact force gradually increases with the change from the oblique collision to the frontal collision. The peak impact force increases with the weight of the ship and shows a nonlinear relationship, such that the peak value of impact force increases with the speed increase, and the speed and the peak values of impact force show basically a linear relationship.
Research on Quantitative Evaluation of Remote Sensing and Statistics Based on Wireless Sensors and Farmland Soil Nutrient Variability
Authors: Ji Weishuai , Liu Yaqiu
Published: January 2022

The combination of wireless sensor networks and radio technology can form a new type of communication network. The emergence of wireless sensor networks has effectively solved the problems existing in radio technology, but traditional wireless sensor networks and radio technology networks cannot be directly applied to wireless sensors. On this basis, this paper studies the remote sensing of soil nutrient variability in agricultural land using wireless sensors. Due to traditional farmland management and agricultural systems, farmland soil nutrient variability has led to polarization: fertile soil has excess nutrients, reducing the use rate of chemical fertilizers and polluting high-quality farmland. Traditional farming methods can no longer meet the requirements, and modern technology must be used to comprehensively understand the spatiotemporal variability of soil nutrients during plant growth. Remote sensing technology has the advantages of accuracy, speed, economy, and regular monitoring. It provides new ideas and technical guarantees for soil quality evaluation in land development and consolidation projects. This paper also studies the use of statistical quantitative evaluation technology to carry out multidimensional statistical quantification of soil protection function evaluation at a given location. Finally, wireless sensor networks are used to analyze the relationship between several natural factors and quantitative estimation of soil protection. Based on wireless sensor technology, this paper studies the variability of farmland soil nutrients and statistical quantitative evaluation, hoping to lay a foundation for the development of agriculture and statistics.
Surface Defect Detection Method Based on Improved Semisupervised Multitask Generative Adversarial Network
Authors: Zhu Lin , Baolin Du , Xiaomeng Zhao , Shaoliang Fang , Zhen Che , Junjie Zhou , Shumin Chen
Published: January 2022

The detection methods based on deep learning networks have attracted widespread interest in industrial manufacture. However, the existing methods are mainly trapped by a large amount of training data with excellent labels and also show difficulty for the simultaneous detection of multiple defects in practical detection. Therefore, in this article, a defect detection method based on improved semisupervised multitask generative adversarial network (iSSMT-GAN) is proposed for generating better image features and improving classification accuracy. First, the training data are manually labeled according to the types of defects, and the generative adversarial network (GAN) is constructed according to the reliable annotations about defects. Thus, a classification decision surface for the detection of multitype defects is formed in the discriminative network of GAN in an integrated manner. Moreover, the semisupervised samples generated by the discriminative network give the generative network feedback for enhancing the image features and avoiding gradient disappearance or overfitting. Finally, the experimental results show that the proposed method can generate high-quality image features compared with the classic GAN. Furthermore, this increase in classification accuracy of RegNet model, MobileNet v3 model, VGG-19 model, and AlexNet-based transfer learning is 3.13%, 2.30%, 2.48%, and 3.12%, respectively.
Artificial Intelligence Interactive Design System Based on Digital Multimedia Technology
Authors: Liu Chengcheng
Published: January 2022

The current extraction speed of artificial intelligence interactive elements is low, with the low effect, resulting in the poor effect of artificial intelligence interaction. Therefore, a new artificial intelligence interaction method has been developed for digital multimedia technology, performing analysis based on the current background of artificial intelligence, providing a good environment foundation for the interactive place, so that it can integrate artificial intelligence technology after interaction. Aiming at the current problems of digital multimedia technology in the use of artificial intelligence interaction design, innovative exploration of artificial intelligence technology will be carried out based on multimedia technology and innovative thinking. Based on the in-depth analysis of digital multimedia technology, the relationship between artificial intelligence technology and digital multimedia technology is analyzed, and an artificial intelligence interactive design system based on digital multimedia technology is proposed. Finally, the digital multimedia technology is verified on the artificial intelligence interactive design through case analysis.
Aqueous Level of ANGPTL4 Correlates with the OCTA Metrics of Diabetic Macular Edema in NPDR
Authors: Xu Qing , Gong Chaoju , Qiao Lei , Feng Ruifang , Liu Haiyang , Liu Yalu , Ji Sujuan , Zhang Yipeng , Wu Shuang , Li Suyan
Published: January 2022

Purpose. To investigate the aqueous levels of angiogenic factors in nonproliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME) and to ascertain their association with optical coherence tomography angiography (OCTA) metrics. Methods. This study enrolled 21 NPDR eyes with DME (NPDR/DME+), 17 NPDR eyes without DME (NPDR/DME-), and 16 diabetic eyes without retinopathy (DWR). Luminex bead-based multiplex array was used to measure the levels of 25 cytokines. OCTA system with a scan area of

3
×
3
 
mm

was used to measure retinal thickness (RT), retinal volume (RV), superficial vessel density (SVD), deep vessel density (DVD), foveal avascular zone (FAZ) area, perimeter and acircularity index. Results. The levels of ANGPTL4 were significantly different among the three groups (

P
<
0.05

), in which NPDR/DME+ group had the highest level and NPDR/DME- group had a higher level than the DWR group (all,

P
<
0.0167

). OCTA examination showed that, compared with DWR and NPDR/DME- group, RT and RV increased and the whole/parafoveal DVD decreased in NPDR/DME+ group (all,

P
<
0.05

). Meanwhile, NPDR/DME- group had lower parafoveal DVD than the DWR group (

P
<
0.05

). Correlation analysis showed that the levels of ANGPTL4 were positively correlated with foveal/parafoveal RT and RV and negatively correlated with whole/parafoveal DVD in NPDR patients (all,

P
<
0.05

). As the influencing factor of RT, RV, and DVD, every additional 103 pg/ml of ANGPTL4 was associated with an increase in foveal and parafoveal RT of 4.299 μm and 3.598 μm, respectively. Every additional 106 pg/ml of ANGPTL4 was associated with an increase in foveal and parafoveal RV of 3.371 mm3 and 17.705 mm3, respectively. Every additional 104 pg/ml of ANGPTL4 was associated with a decrease in whole and parafoveal DVD of 1.705% and 1.799%, respectively. Conclusions. The level of ANGPTL4 in aqueous humor of NPDR patients with DME was significantly increased and ANGPTL4 might predict RT, RV, and parafoveal DVD of DME in NPDR patients.
The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function
Authors: Park Jihyun , Lee Si-Yeon , Jeon Yoon , Kim Kyung-Mo , Lee Jin-Kwan , Ko Jiwon , Park Eun-Ji , Yoon Joon-Sup , Kang Baeki E. , Ryu Dongryeol , Lee Ho , Shin Su-Jin , Go Heounjeong , Lee Chang-Woo
Published: January 2022

CD8+ T cells play an important role in the elimination of tumors. However, the underlying mechanisms involved in eliciting and maintaining effector responses in CD8+ T cells remain to be elucidated. Pellino1 (Peli1) is a receptor signal-responsive ubiquitin E3 ligase, which acts as a critical mediator for innate immunity. Here, we found that the risk of developing tumors was dependent on Peli1 expression. Peli1 was upregulated in CD8+ T cells among tumor-infiltrating lymphocytes (TIL). In contrast, a deficit of Peli1 enhanced the maintenance and effector function of CD8+ TILs. The development of Peli1-deficient CD8+ TILs prevented T-cell exhaustion and retained the hyperactivated states of T cells to eliminate tumors. We also found that Peli1 directly interacted with protein kinase C-theta (PKCθ), a central kinase in T-cell receptor downstream signal transduction, but whose role in tumor immunology remains unknown. Peli1 inhibited the PKCθ pathway by lysine 48–mediated ubiquitination degradation in CD8+ TILs. In summary, the Peli1–PKCθ signaling axis is a common inhibitory mechanism that prevents antitumor CD8+ T-cell function, and thus targeting Peli1 may be a useful therapeutic strategy for improving cytotoxic T-cell activity.
ABC6 Consensus: Assessment by a Group of German Experts
Authors: Lüftner Diana , Fasching Peter A. , Haidinger Renate , Harbeck Nadia , Jackisch Christian , Müller Volkmar , Schumacher-Wulf Eva , Thomssen Christoph , Untch Michael , Würstlein Rachel
Published: January 2022

Background: The first International Consensus Conference for Advanced Breast Cancer (ABC1) took place 10 years ago in November 2011. The rationale was – and still is – to standardize treatment of advanced breast cancer (ABC) based on the available evidence and to ensure that worldwide all breast cancer patients receive adequate treatment and access to new therapies. Rationale for the Manuscript: The 6th International Consensus Conference for ABC (ABC6) took place from November 4 to 6, 2021 and was the first in a purely online format, due to the COVID-19 pandemic. In the present manuscript, a working group of German breast cancer experts comments on the voting results of the ABC6 panelists regarding their applicability for routine clinical practice in Germany. Method: The ABC6 votes mainly include modified or new statements. With regard to all statements not modified for the ABC6 consensus, the German experts refer to the published paper of the ABC5 consensus. The German experts base their comments on the current recommendations of the Breast Committee of the Gynecological Oncology Working Group (Arbeitsgemeinschaft Gynäkologische Onkologie, AGO Mamma). Topics: ABC6 focused on new treatment options and their implications for clinical practice. Optimal therapy sequencing for example was one of the issues. To solve the challenge of a more individualized treatment, precision medicine is fundamental. Oligometastatic disease, brain metastases and adequate supportive and palliative care were also addressed. Of special interest was the treatment of inoperable locally advanced breast cancer, which was discussed as a separate topic. As in previous years, patient advocates from around the world were an integral part of the ABC6 conference and had a major input into the consensus.
Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2
Authors: Bárez-López Soledad , Konopacka Agnieszka , Cross Stephen J. , Greenwood Mingkwan , Skarveli Marina , Murphy David , Greenwood Michael P.
Published: January 2022

Introduction: Water homoeostasis is achieved by secretion of the peptide hormones arginine vasopressin (AVP) and oxytocin (OXT) that are synthesized by separate populations of magnocellular neurones (MCNs) in the supraoptic and paraventricular (PVN) nuclei of the hypothalamus. To further understand the molecular mechanisms that facilitate biosynthesis of AVP and OXT by MCNs, we have explored the spatiotemporal dynamic, both mRNA and protein expression, of two genes identified by our group as being important components of the osmotic defence response: Caprin2 and Creb3l1. Methods: By RNA in situ hybridization and immunohistochemistry, we have characterized the expression of Caprin2 and Creb3l1 in MCNs in the basal state, in response to dehydration, and during rehydration in the rat. Results: We found that Caprin2 and Creb3l1 are expressed in AVP and OXT MCNs and in response to dehydration expression increases in both MCN populations. Protein levels mirror the increase in transcript levels for both CREB3L1 and CAPRIN2. In view of increased CREB3L1 and CAPRIN2 expression in OXT neurones by dehydration, we explored OXT-specific functions for these genes. By luciferase assays, we demonstrate that CREB3L1 may be a transcription factor regulating Oxt gene expression. By RNA immunoprecipitation assays and Northern blot analysis of Oxt mRNA poly(A) tails, we have found that CAPRIN2 binds to Oxt mRNA and regulates its poly(A) tail length. Moreover, in response to dehydration, Caprin2 mRNA is subjected to nuclear retention, possibly to regulate Caprin2 mRNA availability in the cytoplasm. Conclusion: The exploration of the spatiotemporal dynamics of Creb3l1- and Caprin2-encoded mRNAs and proteins has provided novel insights beyond the AVP-ergic system, revealing novel OXT-ergic system roles of these genes in the osmotic defence response.
Noninvasive Investigation of the Presence and Extent of Coronary Artery Disease by the Evaluation of Fingertip-Reactive Hyperemia
Authors: Fatihoglu Sefik Gorkem , Jam Farzin , Okutucu Sercan , Oto Ali
Published: January 2022

Objective: Fingertip-reactive hyperemia-peripheral artery tonometry (RH-PAT) is an emerging novel noninvasive method for evaluating endothelial function. We aimed to evaluate endothelial function with fingertip-reactive hyperemia by RH-PAT in symptomatic patients undergoing elective coronary angiography and to assess the relationship between the degree of endothelial dysfunction (ED) and the presence and the severity of coronary artery disease (CAD). Subjects and Methods: We assessed 92 patients. Before coronary angiography, endothelial function was measured by RH-PAT and reactive hyperemia index (RHI) was obtained. For each patient, the Gensini score was calculated according to the coronary angiographic findings to evaluate the severity of CAD. Results: In CAD (+) group, RHI (1.35 ± 0.57 vs. 1.74 ± 0.46, p = 0.001) mean values were lower than CAD (−) group. In multivariate logistic regression analysis, age, high-density lipoprotein, and RHI were found to be independent parameters predicting the presence of CAD. In multivariate linear regression analysis, RHI was found to be an independent predictor associated with the severity of CAD. In receiver operating characteristic curve analysis, RHI achieved an area under the curve of 0.763 (95% confidence interval 0.663–0.846, p = 0.001) for the ability to predict the presence of CAD. A cut-off value of 1.49 for an RHI predicted the presence of CAD with a sensitivity of 75% and a specificity of 72.9%. Conclusion: RH-PAT is an objective and highly reproducible test with superior diagnostic accuracy for the evaluation of ED. We found significant correlations between ED and the presence and the severity of CAD.
Pemeriksaan Histopatologi dan Imunofluoresen pada Pemfigus Vulgaris
Authors: Devitasari Rizky , Yuniaswan Anggun , Retnani Diah
Published: January 2022

Pemphigus vulgaris (PV) adalah suatu penyakit autoimun yang ditandai lepuhan pada kulit dan membran mukosa. Lesi primer PV adalah terdapat lepuhan kendur dengan predileksi pada seluruh permukaan kulit dan mukosa. Tes diagnostik untuk menegakkan diagnosis PV terhadap penyakit vesikobulosa yang lain, meliputi biopsi kulit ataupun mukosa untuk pemeriksaan histopatologi dan immunoflouresence (IF). Gambaran histopatologi yang ditemukan berupa adanya intraepithelial blister dan achantolysis suprabasilar dengan ciri khas row of tombstone yang merupakan hasil dari IgG autoantibodi terhadap glikoprotein desmoglein 3 (dsg3) dan sebagian terhadap desmoglein 1 (dsg1). Pemeriksaan direct immunoflourescence menunjukkan deposit IgG, IgM dan C3 di ruang antar sel dalam epitel.
Mediação da leitura com o idoso: perspectivas a partir da literatura científica da Ciência da Informação
Authors: Calheira Fausto José Silva , Santos Raquel do Rosário
Published: January 2022

A população idosa tem crescido cada vez mais. Esse fenômeno é oriundo de diferentes fatores, dentre eles, o aumento da expectativa de vida e o avanço da Medicina. Com base nessas inferências, é necessário adotar práticas que possam contribuir para melhorar a qualidade de vida na terceira idade. O ato de ler e sua dinâmica possibilitam que os idosos possam formar novos conceitos sobre o mundo em que vivem, sobretudo, o papel que desempenham na sociedade e na família. Dessa maneira, a mediação da leitura torna-se relevante ao proporcionar bem-estar e ajudar os idosos a superarem problemas de comunicação e de interação. Nessa perspectiva, o objetivo desta pesquisa foi analisar, com base na literatura da Ciência da Informação, como a mediação da leitura ao ser realizada de maneira consciente pode contribuir com a vida sociocultural do idoso. Quanto à metodologia, trata-se de uma pesquisa bibliográfica que se pauta nos estudos da Ciência da Informação sobre a mediação da leitura voltada aos idosos. Considerando as reflexões apresentadas sobre a mediação da leitura, entende-se que ela é sobremaneira importante na vida dos idosos e pode colaborar para o processo de inclusão social e bem-estar. Constatou-se também que a mediação consciente da leitura pode colaborar com a qualidade de vida do idoso, trazendo benefícios para o biopsicossocial desses sujeitos.
Encontros com V. V. Ivánov
Authors: Ferreira Jerusa Pires
Published: January 2022

A partir dos encontros pessoais com V. V. Ivánov, especialmente na entrevista gravada em 2015 na UCLA, a autora desdobra neste ensaio aspectos da contribuição transdisciplinar do pensador russo ao ligar o arcaico ao futuro.
Apontamentos sobre Boris, Jerusa, florestas de signos e afinidades eletivas
Authors: Medeiros Gutemberg
Published: January 2022

Gutemberg Medeiros percorre momentos-chave da vida e da obra de Boris Schnaiderman ao introduzir no Brasil as arquiteturas teóricas de Mikhail Bakhtin, Roman Jakobosn e da semiótica da cultura de Tártu-Moscou, especialmente de V. V. Ivánov.
A Alteridade do Semelhante: desvendando a face do marroquino-faca em Shum Gamadim Lô Yavô’u, de Sara Shilo
Authors: Oliveira Leopoldo Osório de
Published: January 2022

Através da análise do romance Shum Gamadim Lô Yavo’ú (sem tradução para o português), o presente trabalho se propõe a examinar os percalços e vieses da inserção de imigrantes judeus-marroquinos na sociedade israelense, bem como examinar o impacto que este romance peculiar pode suscitar nos debates sobre literatura, sua feição e função para o judaísmo como um todo e para a sociedade israelense em particular.
Achando repouso para a bússola do coração: o conceito hebraico de tempo em Kierkegaard
Authors: Ribeiro Andre Oswaldo
Published: January 2022

Nos estudos sobre Kierkegaard e a tradição judaica, é comum a discussão da análise kierkegaardiana da aqedah de Isaac. No entanto, um aspecto decisivo da antropologia de Kierkegaard é o problema da experiência do tempo. Neste artigo, discutiremos dois modos antagônicos de vivenciar o tempo: o desespero de um tempo corrosivo versus a confiança proveniente de um tempo dentro da eternidade. Analisaremos a relação entre a antropologia de Kierkegaard e a noção hebraica de tempo que emerge do relato cosmogônico de Gn 2 mediante o exame de três categorias existenciais kierkegaardianas: o instante, a repetição e a contemporaneidade consigo mesmo. Partindo da torah e de uma anotação de Kierkegaard sobre o tempo judaico escrita em 1837, discutiremos os mistérios e os dramas da experiência do tempo no seio de uma antropologia da redenção do homem e do tempo.
geografía del desarraigo
Authors: Castro Méndez Carlos Enrique , Suzuki Julio Cesar , Araújo Gilvan Charles Cerqueira de
Published: January 2022

La pérdida de sentido social que menoscaba las raíces se considera un fenómeno que ocurre en los seres humanos, que destruye los lazos familiares, y a su vez es capaz de producir una identidad comunitaria cargada de ausencia y de sentido vital. Esto conlleva a una mezcla de culturas y comportamientos sociales que repercuten en la vida emocional de las personas y se manifiesta en los grupos sociales cuando la economía interviene el medio ambiente y se produce la desterritorialización de sus espacios de vida. El análisis geográfico de la obra de cine The Grapes of wrath producida en 1940, permite estudiar las consecuencias sociales y el desarraigo de la población cuando finaliza un ciclo económico y comienza. El análisis de la obra permitió comprender los procesos sociales a través de las reacciones de los protagonistas que fueron sometidos a un cambio económico y cultural generado por problemas ambientales recurrentes.
Entre utopias abstratas e concretas
Authors: Fonseca Lunardon Kauan Arthur
Published: January 2022

Os rebatimentos da pandemia COVID-19 nos espaços públicos são difusos e contraditórios. Ao mesmo tempo que a não interrupção das atividades comerciais e de serviços - senão em ocasiões pontuais - mantiveram os mesmos em seu movimento habitual, praticamente todos os usos que não aqueles diretamente relacionados à produção e reprodução da cidade capitalista foram inviabilizados, deslocados, senão coibidos. Assumindo, como Massey (2008) que a maneira como imaginamos o espaço influencia na forma como o praticamos, entendemos que se debruçar sobre os tipos de imaginários urbanos pode ser um caminho interessante para pensar não apenas os tempos pandêmicos, mas também as cidades possíveis dentro da distopia vivenciada. Assim, a utopia e a distopia se colocam aqui como portas de entrada para propor algumas considerações sobre os espaços públicos contemporâneos. A primeira porta é através do imaginário cyberpunk, gênero literário e cinematográfico, e a segunda através da obra Nova-Babilônia do artista ex-integrante da Internacional Situacionista, Constant Nieuwenhuys.
Impact of Chronic Kidney Disease on the Associations of Cardiovascular Biomarkers With Adverse Outcomes in Patients With Suspected or Known Coronary Artery Disease: The EXCEED‐J Study
Authors: Wada Hiromichi , Shinozaki Tsuyoshi , Suzuki Masahiro , Sakagami Satoru , Ajiro Yoichi , Funada Junichi , Matsuda Morihiro , Shimizu Masatoshi , Takenaka Takashi , Morita Yukiko , Yonezawa Kazuya , Matsubara Hiromi , Ono Yujiro , Nakamura Toshihiro , Fujimoto Kazuteru , Ninomiya Akiyo , Kato Toru , Unoki Takashi , Takagi Daisuke , Wada Kyohma , Wada Miyaka , Iguchi Moritake , Yamakage Hajime , Kusakabe Toru , Yasoda Akihiro , Shimatsu Akira , Kotani Kazuhiko , Satoh‐Asahara Noriko , Abe Mitsuru , Akao Masaharu , Hasegawa Koji ,   for the EXCEED‐J Study Investigators
Published: January 2022

Background

The impact of chronic kidney disease (CKD) on the prognostic utility of cardiovascular biomarkers in high‐risk patients remains unclear.

Methods and Results

We performed a multicenter, prospective cohort study of 3255 patients with suspected or known coronary artery disease (CAD) to investigate whether CKD modifies the prognostic utility of cardiovascular biomarkers. Serum levels of cardiovascular and renal biomarkers, including soluble fms‐like tyrosine kinase‐1 (sFlt‐1), N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), high‐sensitivity cardiac troponin‐I (hs‐cTnI), cystatin C, and placental growth factor, were measured in 1301 CKD and 1954 patients without CKD. The urine albumin to creatinine ratio (UACR) was measured in patients with CKD. The primary outcome was 3‐point MACE (3P‐MACE) defined as a composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke. The secondary outcomes were all‐cause death, cardiovascular death, and 5P‐MACE defined as a composite of 3P‐MACE, heart failure hospitalization, and coronary/peripheral artery revascularization. After adjustment for clinical confounders, sFlt‐1, NT‐proBNP, and hs‐cTnI, but not other biomarkers, were significantly associated with 3P‐MACE, all‐cause death, and cardiovascular death in the entire cohort and in patients without CKD. These associations were still significant in CKD only for NT‐proBNP and hs‐cTnI. NT‐proBNP and hs‐cTnI were also significantly associated with 5P‐MACE in CKD. The UACR was not significantly associated with any outcomes in CKD. NT‐proBNP and hs‐cTnI added incremental prognostic information for all outcomes to the model with potential clinical confounders in CKD.

Conclusions

NT‐proBNP and hs‐cTnI were the most powerful prognostic biomarkers in patients with suspected or known CAD and concomitant CKD.
Computational approaches to treatment response prediction in major depression using brain activity and behavioral data: A systematic review
Authors: Karvelis Povilas , Charlton Colleen E. , Allohverdi Shona G. , Bedford Peter , Hauke Daniel J. , Diaconescu Andreea O.
Published: January 2022

Major depressive disorder is a heterogeneous diagnostic category with multiple available treatments. With the goal of optimizing treatment selection, researchers are developing computational models that attempt to predict treatment response based on various pretreatment measures. In this paper, we review studies that use brain activity data to predict treatment response. Our aim is to highlight and clarify important methodological differences between various studies that relate to the incorporation of domain knowledge, specifically within two approaches delineated as data-driven and theory-driven. We argue that theory-driven generative modeling, which explicitly models information processing in the brain and thus can capture disease mechanisms, is a promising emerging approach that is only beginning to be utilized in treatment response prediction. The predictors extracted via such models could improve interpretability, which is critical for clinical decision-making. We also identify several methodological limitations across the reviewed studies and provide suggestions for addressing them. Namely, we consider problems with dichotomizing treatment outcomes, the importance of investigating more than one treatment in a given study for differential treatment response predictions, the need for a patient-centered approach for defining treatment outcomes, and finally, the use of internal and external validation methods for improving model generalizability.
First discovery of the Neotropical species Brachymeria trinidadensis (Hymenoptera: Chalcididae, Brachymeriinae) in India
Authors: BINOY C. , SANTHOSH S. , NASSER M.
Published: January 2022

Brachymeria trinidadensis (Narendran & Varghese) (Hymenoptera: Chalcididae), described originally from Trinidad, West Indies, is newly reported from the state of Kerala, India, as a likely accidental introduction. A possible parasitoid association with an unidentified Bembix (Hymenoptera: Crabronidae) larva feeding on an unidentified species of Tabanidae (Diptera) is suggested based on collection of the female near the Bembix tunnel. The species is redescribed based on the Kerala female and it and the female holotype of B. trinidadensis are both illustrated with colour photographs. Brachymeria trinidadensis is considered a ‘long tailed’ species of Brachymeria based on females of the species having a conspicuously elongate syntergum, but is removed from the subconica species group of Brachymeria based on the head lacking a transverse carina across the vertex posterior of the median ocellus. Brachymeria laetiliae Burks is also removed from the subconica species group based on the head lacking the transverse carina. Type material of the long tailed species B. grisselli (Narendran & Varghese), B. kraussi (Narendran & Varghese), B. aculeata (Walker) and B. producta (Olivier) are illustrated by photographs. Variation of B. trinidadensis from other long tailed (syntergum) congeners is also provided.
Ummidia insularis new species, first record of the family Halonoproctidae (Araneae: Mygalomorphae) for Hispaniola
Authors: DE LOS SANTOS GABRIEL , ORTIZ DAVID , SÁNCHEZ-RUIZ ALEXANDER
Published: January 2022

Ummidia is among the most ancient, highly diversified, widespread, morphologically static, and cryptic genera of mygalomorph spiders. Therefore, it constitutes a unique subject to investigate evolutionary processes, but also a very challenging group to study. Here, we provide the description and profuse illustration of the male and female of a new species of Ummidia from the Dominican Republic, which also constitutes the first record of the family Halonoproctidae for the island of Hispaniola. With this report, the presence of Ummidia is confirmed for three of the four Greater Antillean islands (Jamaica, Cuba, and Hispaniola), as well as for Guana (with a recent common history with Puerto Rico). Thus, the Antillean Ummidia distribution is consistent with a possible ancient terrestrial dispersal from South America during the Late Eocene to Early Oligocene, a pattern also shared by other philopatric organisms.
Optimization of the image contrast for the developing fetal brain using 3D radial VIBE sequence in 3 T magnetic resonance imaging
Authors: Liao Yi , Li Xuesheng , Jia Fenglin , Ye Zhijun , Ning Gang , Liu Sai , Li Pei , Fu Chuan , Li Qing , Wang Shaoyu , Zhang Huapeng , Qu Haibo
Published: January 2022

Background

Faster and motion robust magnetic resonance imaging (MRI) sequences are desirable in fetal brain MRI. T1-weighted images are essential for evaluating fetal brain development. We optimized the radial volumetric interpolated breath-hold examination (VIBE) sequence for qualitative T1-weighted images of the fetal brain with improved image contrast and reduced motion sensitivity.

Materials and methods

This was an institutional review board-approved prospective study. Thirty-five pregnant subjects underwent fetal brain scan at 3 Tesla MRI. T1-weighted images were acquired using a 3D radial VIBE sequence with flip angles of 6º, 9º, 12º, and 15º. T1-weighted images of Cartesian VIBE sequence were acquired in three of the subjects. Qualitative assessments including image quality and motion artifact severity were evaluated. The image contrast ratio between gray and white matter were measured. Interobserver reliability and intraobserver repeatability were assessed using intraclass correlation coefficient (ICC).

Results

Interobserver reliability and intraobserver repeatability universally revealed almost perfect agreement (ICC > 0.800). Significant differences in image quality were detected in basal ganglia (P = 0.023), central sulcus (P = 0.028), myelination (P = 0.007) and gray matter (P = 0.023) among radial VIBE with flip angles 6º, 9º, 12º, 15º. Image quality at the 9º flip angle in radial VIBE was generally better than flip angle of 15º. Radial VIBE sequence with 9º flip angle of gray matter was significantly different by gestational age (GA) before and after 28 weeks (P = 0.036). Quantified image contrast was significantly different among different flip angles, consistent with qualitative analysis of image quality.

Conclusions

Three-dimensional radial VIBE with 9º flip angle provides optimal, stable T1-weighted images of the fetal brain. Fetal brain structure and development can be evaluated using high-quality images obtained using this angle. However, different scanners will achieve different TRs and so the FA should be re-optimized each time a new protocol is employed.
Phenotypic diversity among juvenile polyposis syndrome patients from different ethnic background
Authors: Katz Lior Haim , Gingold-Belfer Rachel , Vainer Elez , Hegger Shani , Laish Ido , Derazne Estela , Weintraub Ilana , Reznick-Levi Gili , Goldberg Yael , Levi Zohar , Cohen Shlomi , Half Elizabeth E.
Published: January 2022

Juvenile polyposis syndrome (JPS), has diverse phenotypes. Aim: To assess mutation rate, clinical features and genotype-phenotype correlation among Israeli JPS kindreds from different ethnicities.

Methods

Patients’ data were extracted retrospectively from 5 centers.

Results

Thirty five kindreds (49 patients) were included. Thirty one (89%) Jewish [10 (32%) Ashkenazi; 9 (29%) Sephardi; 11 (35%) non-Russia former Soviet-Union countries (NRFSU), one (3%) unknown]. 40/49 individuals from 27 families underwent genetic testing. Among them 34, from 21 families (85, 78%, respectively) had a pathogenic mutation: BMPR1A n = 15 (71%), SMAD4 n = 6 families (29%). While no SMAD4 mutation was described among Jewish families from NRFSU, 7 NRFSU families carried a founder mutation comprising a large genomic deletion of BMPR1A. GI involvement was reported in 42 patients (86%): colonic polyps (n = 40, 95%, > 50 polyps n = 14, 35%) and 12 underwent colonic resection. Fourteen patients (34%) had gastric or small bowel involvement (n = 5) and 4\14 underwent gastrectomy due to polyp burden. Families from NRFSU had more gastric involvement (66.7% vs. 22.2%- Sephardic and 20%- Ashkenazi Jews; p = 0.038), with more gastric polyps (p = 0.017).

Conclusions

We demonstrated a high rate of mutation detection in the heterogeneous population of Israel. Patients from NRFSU with BMPR1A mutation had high rate of gastric involvement.
COVID-19 with peripartum cardiomyopathy: a case report
Authors: Karna Sunaina Tejpal , Thaware Pooja , Singh Pooja
Published: January 2022

Background

The world has been facing the novel coronavirus SARS-CoV-2 pandemic. The novel coronavirus primarily affects the lungs but also affects multiple organ systems including the cardiovascular system causing myocarditis, cardiomyopathy, and arrhythmias. Cardiomyopathy has been reported in patients with COVID-19; however, prognosis of peripartum cardiomyopathy in a patient with COVID-19 is still unexplored. More knowledge is required to understand the incidence of cardiomyopathy due to novel coronavirus SARS-CoV-2.

Case presentation

We report a case of peripartum cardiomyopathy gravida 2 parity 2 COVID-19 confirmed patient who underwent an emergency preterm lower segment caesarean section (LSCS) for severe pre-eclampsia and intra-uterine growth retardation (IUGR) and landed up in acute congestive cardiac failure with pulmonary oedema. A postpartum 32 years female presented to our institute, a dedicated COVID-19 hospital with tachycardia, hypertension, anasarca, tachypnea with desaturation on room air. She had undergone emergency caesarean section for severe preeclampsia with intrauterine growth retardation. On post-operative day 2 (POD2), she complained of shortness of breath. On POD 3 she tested positive RT-PCR for COVID-19 infection. She responded to treatment with steroids. However, on POD6, She developed severe pulmonary oedema with poor ejection fraction necessitating endotracheal intubation and pressure control ventilation. Congestive cardiac failure was managed with diuretics and digoxin. Gradually oxygenation improved. She was electively ventilated for 3 days. Gradually, ejection fraction improved with the resolution of B lines. On the 9th POD, after a successful spontaneous breathing trial, she was extubated and non-invasive ventilation with bi-level positive airway pressure was attached. The patient was gradually tapered off of the non-invasive ventilation over 2 days. On the 11th post-operative day, she was maintaining oxygen saturation on nasal prongs and was sent to the ward.

Conclusions

We recommend early use of bedside lung ultrasonography; echocardiography and close cardiovascular monitoring in severe COVID-19 infected pregnant patients who present with shortness of breath, tachypnea, and hypertensive disorders of pregnancy and previous cardiac abnormalities for expedite management and improved prognosis. An ideal case scenario for extubation may not be present, non-invasive ventilation with bi-level positive airway pressure post-extubation helps in patients with peripartum cardiomyopathy.
The Narrative Garden
Authors: Santesso Aaron
Published: January 2022

Critics have long pointed to the connections between eighteenth-century landscape gardens and poetry. This essay examines the influence of prose narrative on garden design, arguing that gardens increasingly reflect narrative techniques as the eighteenth century progresses. The essay also considers the relevance of narratology to nonliterary fields and subjects.
Managed Catastrophe: Problem-Solving and Rhyming Couplets in the Seventeenth-Century Country House Poem
Authors: Netzley Ryan
Published: January 2022

In celebrating a poet-overseer who turns everything on an estate, even social opposition, to account, country house poems treat form itself as a managerial technique whose expansion regulates catastrophe. Ben Jonson's, Thomas Carew's, and Robert Herrick's procataleptic presentations of what's absent from the country house—a rude steward counting one's cups—repurpose resentment into a celebration of lordly generosity. Yet this solution to the problem of resentment is paradoxical insofar as the plenty underlying the lords’ generosity does not require management. Aemilia Lanyer and Andrew Marvell use the rhyming couplet, the genre's paratactic generative principle, to depict decision-making's growth as a botanical phenomenon. Together these formal features show how problem-solving stewardship grows mindlessly, impractically, and very much like a plant. In that respect, these poems hint that problem-solving can never avert a climate catastrophe, precisely because of managerial decision-making's impulse to produce ever more of itself.
Synthesis of Dibenzo[h,t]rubicene through Its Internally Dimethoxy-substituted Precursor
Authors: Kato Masaki , Fukui Norihito , Shinokubo Hiroshi
Published: January 2022

Dibenzo[h,t]rubicene was synthesized from 1,5-dichloroanthraquinone via an internally dimethoxylated intermediate. In contrast to the planar conformation of rubicene, dibenzo[h,t]rubicene adopted a double-helicene-like structure due to the intramolecular steric repulsion around the fused benzene-rings. Theoretical calculation suggests that the helical inversion occurs frequently with an inversion barrier of 4.8 kcal mol−1. The HOMO–LUMO gap of dibenzo[h,t]rubicene is smaller than that of rubicene, resulting in its red-shifted absorption tailing to 690 nm.
Φιλοσοφικός αθεϊσμός και παραδοσιακή θρησκευτικότητα
Authors: Πότσα Ελένη
Published: January 2022

Η παρούσα διδακτορική διατριβή επικεντρώνεται στην επικούρεια θεολογία στο πλαίσιο της «ελληνιστικής θεολογίας», της θρησκείας και του αθεϊσμού, με σκοπό να ανασυγκροτήσει τη θέση του επικουρισμού ανάμεσα στην παραδοσιακή θρησκευτικότητα και τη φιλοσοφική θεολογία και τον αθεϊσμό, ανάμεσα δηλαδή, στον Θεό των Θρησκειών και τον Θεό των Φιλοσόφων. Εξετάζεται, επιπλέον, η σχέση του επικουρισμού με τον Θεό των Ποιητών. Στο ίδιο πλαίσιο ανασυγκροτείται ο χαρακτήρας της αρχαίας ελληνικής θρησκείας και της θρησκείας κατά τα ελληνιστικά χρόνια, καθώς αναλύεται και το είδος του αθεϊσμού στην αρχαιότητα. Ειδικότερα, η εργασία αυτή αναπτύσσει μια «επικούρεια κριτική θεολογία» ‒όπως ανασυγκροτείται από τον Επίκουρο αλλά και από τους Λουκρήτιο και Φιλόδημο‒ με βάση τις σύγχρονες κατηγοριοποιήσεις και της φιλοσοφικής θεολογίας και του φιλοσοφικού αθεϊσμού, με σκοπό την επανένταξη και την επανανάγνωση του επικουρισμού στην ιστορία του φιλοσοφικού αθεϊσμού. Η προσέγγιση συγκροτείται μέσα από κοινές θεματικές (όπως για παράδειγμα η αρχή του κόσμου, η απειρότητα, η θνητότητα, ο θάνατος, η αθανασία ψυχής, η πρόνοια, το νόημα ζωής, το πρόβλημα του κακού, η ελεύθερη βούληση) που ανταποκρίνονται και στην επικούρεια θεολογία. Κατά την ανάπτυξη των θεματικών, παρουσιάζεται η επιχειρηματολογία των Επικουρείων σε αντιπαραβολή με άλλες παραδόσεις και φιλοσοφίες και καταγράφονται τα τελολογικά και κοσμολογικά επιχειρήματα που επικαλούνται. Παρουσιάζεται, επίσης, και μια «επικούρεια θεωρία της θρησκείας», η οποία επιχειρεί να αναδείξει τον τρόπο με τον οποίο οι άνθρωποι θα έπρεπε, σύμφωνα με τον Επίκουρο, να αντιμετωπίζουν τη θρησκεία. Με τον τρόπο αυτόν, γίνεται προσπάθεια να καθοριστεί η θέση των Επικουρείων τόσο ως προς την παραδοσιακή-πρακτική θρησκεία όσο και τη φιλοσοφική παράδοση αναφορικά με τα ζητήματα του θείου και, κατά συνέπεια, φαίνονται οι επιμέρους ομοιότητες αλλά και οι διαφορές του Επίκουρου τόσο ως προς τη θρησκευτική παράδοση όσο και ως προς τη φιλοσοφική. Γίνεται, επίσης, προσπάθεια να απαντηθεί το ζήτημα της «αθεΐας» του Επίκουρου. Ο τρόπος με τον οποίο οι Επικούρειοι, κυρίως ο Λουκρήτιος και ο Φιλόδημος, ανατρέπουν τις κατηγορίες περί αθεϊσμού είναι η εὐσέβεια, έννοια την οποία αρχικά ενσωματώνουν στο επικούρειο σύστημα και έπειτα επιχειρούν να αποδείξουν ότι ως στάση τηρείται εκ μέρους του Επίκουρου. Συνολικά, διαφαίνονται ευρύτερες και επιμέρους σχέσεις της θρησκευτικής-θεϊστικής παράδοσης με την αρχαία ελληνική θρησκεία και φιλοσοφία, αν και επισημαίνεται η αναφορά του Επίκουρου σε ένα διαφορετικό κυρίως πολιτισμικά πλαίσιο και σε ένα πολυθεϊστικό. Απώτερος στόχος είναι η ανάδειξη της συνεισφοράς του επικουρισμού εν συνόλω στη συστηματοποίηση, εννοιολόγηση και κριτική της παραδοσιακής θρησκευτικότητας κατά την ελληνιστική περίοδο και τη μετέπειτα φιλοσοφική και θεολογική σκέψη.
Synthesizing the links between secure housing tenure and health for more equitable cities
Authors: Baumgartner Jill , Rodriguez Judith , Berkhout Frans , Doyle Yvonne , Ezzati Majid , Owuso George , Quayyum Zahidul , Solomon Bethlehem , Winters Meghan , Adamkiewicz Gary , Robinson Brian E.
Published: January 2022

Millions of households in rich and poor countries alike are at risk of being unwilfully displaced from their homes or the land on which they live (i.e., lack secure tenure), and the urban poor are most vulnerable. Improving housing tenure security may be an intervention to improve housing and environmental conditions and reduce urban health inequalities. Building on stakeholder workshops and a narrative review of the literature, we developed a conceptual model that infers the mechanisms through which more secure housing tenure can improve housing, environmental quality, and health. Empirical studies show that more secure urban housing tenure can boost economic mobility, improve housing and environmental conditions including reduced exposure to pollution, create safer and more resourced communities, and improve physical and mental health. These links are shared across tenure renters and owners and different economic settings. Broader support is needed for context-appropriate policies and actions to improve tenure security as a catalyst for cultivating healthier homes and neighbourhoods and reducing urban health inequalities in cities.
Travelling Back via Translation: Alai, Lijiang and Minority Literature
Authors: Poupard Duncan
Published: January 2022

Abstract: Tibetan author Alai’s Chinese essay, Yi di shui jingguo Lijiang (一滴水经过丽江 [A drop of water passes through Lijiang]) is a piece of travel writing that describes the city of Lijiang (home to the Naxi minority of Yunnan province) and its environs from the perspective of an anthropomorphic drop of water. The essay has been subsequently translated back into the minority Naxi language of Lijiang by Naxi scholar Mu Chen, and both versions are presented as a lapidary inscription in a tourist square. Writing travel from the reverse perspective, i.e. translating the writing from the minority perspective of the place being travelled, is perhaps a way of counteracting the genre’s inherently epistemic appropriation of the ‘other’. I believe that a comparative approach can act as an antidote against the monolingual, ethnocentric tropes of travel writing. In this essay it will be observed that through back-translation of the travel writing into the Naxi culture being observed, cultural specifics can be reintroduced into a text, and a minority culture can reclaim the power to speak for itself.
Introduction: Eternal Suffering between Reality and Imagination
Authors: Henning Meghan R.
Published: January 2022

This chapter introduces the book’s major themes. It gives an overview of the specific ancient tours of hell that the book will cover (along with their dates and provenance). The Introduction situates the work of the book at the intersection of the history of early Christianity, gender studies and disability studies (with brief and accessible introductions to the relevant scholarly conversations in those fields). The chapter concludes with an explanation of the distinct contributions that the book makes to studies of the history of early Christianity, gender, and disability.