bluuebunny/crossref_metadata_2025 huggingface dataset:
Geografias Culturais do Turismo/Lazer: lições de David Crouch
Authors: Kunz Jaciel Gustavo
Published: October 2021

Eminente geógrafo cultural britânico, David Crouch pesquisa e escreve sobre paisagens, práticas, performances, turismo e lazer há pelo menos vinte anos, e apesar disso, é ainda pouco difundido entre acadêmicos brasileiros do Turismo. Portanto, partindo de revisão de literatura, este ensaio tem como objetivo sistematizar suas contribuições teórico-conceituais centrais para o campo do Turismo. Secundariamente, busca-se identificar as principais influências intelectuais subjacentes a seu trabalho e a evolução das temáticas por ele tratadas. Para Crouch, dada a ênfase em práticas, turismo/lazer é modo distinto de encontro dos sujeitos consigo mesmos, com outros sujeitos, e com espaços, lugares e paisagens. A partir de sua noção de encontros turísticos, o autor entrelaça as possibilidades da performatividade ao conceito de paisagem, ou seja, concebe-a no aspecto “mais-que-representacional”. Assim, Crouch contribui para a pluralização do campo denominado Geografias Culturais do Turismo, que parte da Geografia e pode orientar o estudo do Turismo, em especial de seus sujeitos, que se tornam turistas. Suas proposições e seus argumentos encaminham para uma visão matizada entre turismo e lazer, em que determinadas práticas, inclusive as visuais, permeiam ambos os fenômenos, superando a ideia recorrente de consumo.
BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MEMANTINE HYDROCHLORIDE BY SPECTROFLUORIMETRIC METHOD USING OPA Β-MERCAPTOETHANOL AS DERIVATIZING AGENT
Authors:   Department of Pharmaceutical Analysis Institute of pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Post: Chandlodia, Via: Gota, Ahmedabad - 382 481, Gujarat, India., Patel C. B , Kothari C. S. , Patel N. R , Sherikar O
Published: October 2021

A new, simple, accurate, sensitive and specific bioanalytical spectrofluorimetric method was developed and validated for estimation of memantine hydrochloride (MEM) in human plasma. Estimation of MEM in human plasma was done by spiked human plasma studies. Extraction of MEM from human plasma was carried out using 5% trichloroacetic acid for protein precipitation followed by liquid-liquid extraction with 5% IPA in n-hexane. For spectrofluorimetric estimation delta value 65 applied in synchronous mode (medium sensitivity mode) and fluorescence intensity was measured at 420 nm. Developed method was found linear to be in the concentration range of 50-300 ng/mL with correlation coefficient (R2) 0.9951. Percentage recovery was found to be 77.85-83.68% for MEM. High recovery shows that the method is free from the interference from plasma constituents. Hence, proposed method can be used for estimation of MEM in routine quality control laboratories for quantitative determination of MEM in bulk as well as in human plasma. Further it can also be used to determine plasma MEM concentration in drug monitoring or in pharmacokinetic investigations.
DEVELOPMENT AND CHARACTERIZATION OF NOVEL SITE SPECIFIC FLOATING-MUCOADHESIVE TABLETS BEARING 5-FLOUROURACIL FOR STOMACH TARGETING.
Authors:   Institute of Pharmacy, Bundelkhand University, Jhansi - 284 128, Uttar Pradesh, India., Bhardwaj P , Singh R , Swarup A
Published: October 2021

Object of present investigation was to develop and characterize such a gastroretentive tablet, which provides the synergism effect of adhesiveness and floating property for prolonged release of 5-flourouracil within the stomach. The floating mucoadhesive tablets were prepared by the wet granulation method using different ratios of hydroxy propyl methyl cellulose (HPMC K4MCR) and Carbopol 934P as polymers. The prepared floating-mucoadhesive tables were characterized for hardness, detachment stress, floating properties, swelling index and surface morphology by SEM. The in vitro drug release and floating behaviour were studied in simulated gastric fluid (SGF) at pH 1.2. Different kinetic models for drug release were as well applied. Formulations of T-9 batch were furthermore subjected to stability and in vivo radiographic studies.
UTILITY OF HADKAR FACTOR IN THE DETERMINATION OF CRITICAL MICELLE CONCENTRATION OF SURFACTANTS
Authors:   Mumbai Educational Trust’s Institute of Pharmacy, Bandra (W), Mumbai-400 050, India., Hadkar B. U , Sanghavi N. B.
Published: October 2021

The drop weight method was used to determine the interfacial tension between organic liquid and solutions of different concentrations of the surfactant, sodium lauryl sulphate (SLS), using Hadkar factor. Two experiments were performed to determine the interfacial tension. In the first experiment the drop weight method was used to determine the interfacial tension between water or aqueous surfactant solutions and benzene (liquid lighter than water) using Hadkar factor H1. In the second experiment the drop weight method was used to determine the interfacial tension between water or surfactant solutions and carbon tetrachloride (liquid heavier than water) using Hadkar factor H2. The plot of interfacial tension between benzene or CCl4 and SLS solutions versus concentration of surfactant solution was used to determine the critical micelle concentration (CMC) of the surfactant. The results were in good agreement with the reported values of CMC for SLS showing the utility of Hadkar factor in the determination of CMC of surfactants.
DIABETES-POST-TRANSLATIONAL PROTEIN MODIFICATION FOR DEVELOPMENT OF NEW DRUGS
Authors:   Department of Pharmaceutical Biotechnology, SPP-School of Pharmacy and Technology Management, SVKM’S NMIMS (Deemed to be University) Vile Parle (W), Mumbai-400 056, Maharashtra, India., Menon P , Kumar M S
Published: October 2021

Diabetes is a disorder associated with improper use of glucose by the body leading to increased level of glucose in the blood stream. Beta cells in the pancreas produce the hormone insulin, which is responsible for the movement of glucose into cells where it is utilized to produce energy. Due to the shortage of insulin in diabetic condition, the level of glucose in the bloodstream increases. The level of glucose within cells fall and thus the cells are not able to produce energy using glucose. It also gives rise to various other complications such as blindness, kidney failure, numbness in toes, delayed wound healing, cardiovascular complications, weight gain, loss of consciousness, disorientation etc. which in itself may be dangerous. The root cause of diabetes may either be lack of insulin being produced by the pancreas or development of resistance towards insulin leading to no effect of insulin on the glucose level. Post-translational modifications of protein control various biological processes. It is also considered as an important process in the pathogenesis of diabetes mellitus.In the current review, we will discuss the recent developments in post translational modification of genes associated with diabetes as well as epigenetic modification and metabolic memory that maybe responsible for the onset of diabetes and its associated complications. Currently research is being conducted on high molecular weight adiponectin, peroxisome proliferator-activated receptors (PPARγ), epigenetic histone modifications and Calpain 10 (CAPN10 gene encoded) protein based upon the post translational modifications they undergo and how these modifications affect glucose level regulation. This review article aims at shedding light upon recent advances in biotechnology that are focussed on studying the nature of protein modifications that result in diabetes and finding ways to prevent these modifications or stimulate a new modification that may result in better control of the disease state if not a cure.
PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF SANDALWOOD
Authors: Mehta P. P , Shah R. M , Shinde V. M , Kamble R. N , Mahadik K. R. ,   Bharati Vidyapeeth University, Poona College of Pharmacy, Paud Road, Erandwane, Pune - 411 038, (MH) India.
Published: October 2021

Sandalwood (Santalum album L.) is one of the most famous and widely used plants in perfumery and cosmetics. Apart from perfumery and cosmetics uses, sandalwood also has a wide range of pharmacological activities and the plant can be considered as one of the important medicinal plants. Since last two decades, this plant has been studied extensively but still there is lot of scope to exploit full potential of uses of sandalwood for mankind. Various studies report that of effects sandalwood oil is responsible for various effects ranging from antibacterial to anticancer. It also shows prominent activity in various skin diseases. There are few toxicological studies on sandalwood. It is necessary to summaries all activities reported about this plant. This review consolidates different reported activities of sandalwood plant as well as its oil.
A VALIDATED METHOD DEVELOPMENT FOR ESTIMATION OF SIMVASTATIN BY FIRST ORDER DERIVATIVE SPECTROSCOPY
Authors:   Lafarge Cement plant, Sonadih - 221 715, Dist. Baloda Bazar, C.G. India., Dubey S , Shukla S. S
Published: October 2021

Simvastatin is a hypolipidemic drug used with exercise, diet, and weight-loss to control elevated cholesterol, or hypercholesterolemia. It is a member of the statin class of pharmaceuticals. Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. The drug is marketed generically following the patent expiration, and under the trade name Zocor. The aim of this study is to develop a simple, accurate, precise and economical procedure for estimation of Simvastatin by first order derivative spectroscopy. The method is based upon determination of D1 value of the drug at, in Methanol. Different analytical performance parameters such as linearity, range, system precision, robustness, sensitivity and accuracy were determined according to the ICH guidelines. Simvastatin at its λ max shows linearity in the concentration range 10-60μg/mL.
DESIGN, DEVELOPMENT AND CHARACTERIZATION OF SIMVASTATIN LOADED TRANSFERSOMAL GEL FOR TRANSDERMAL DRUG DELIVERY
Authors:   Bapatla college of pharmacy, Bapatla- 522210. Guntur District, Andhra Pradesh, India., Kumar A.S , Ramesh B , Kavya P , Deepika V. , Kishore S. , Babu K.
Published: October 2021

The objective of the present study was to develop a controlled release transdermal drug delivery systems of simvastatin using lipid vesicular systems incorporated in a Carbopol gel, which will control the release of drug, increasing the bioavailability of the drug and thus decreasing the dosing frequency of the drug. The thin film hydration method or conventional rotary evaporation sonication method was used to prepare the transfersomes formulation. Experimental results of the present study showed that deformable lipid vesicles improve the transdermal delivery, prolong the release, and improve the site specificity of the lipophilic model drug, simvastatin. The drug diffusion studies showed that a transfersome vesicle follows zero order and mechanism of release follows Peppas model. In vivo study of optimized transfersomal gel formulation on suitable rodent model showed better biological anti-hyperlipidemic activity in comparison with reference formulation. Lipid:surfactant ratio of 85:15 is more effective when compared to other formulations because of its Higher flexibility and lesser particle size.
Foreword to Volume 29
Authors: Pathak Yogesh
Published: October 2021

This is the foreword to Volume 29 of Journal of Ecological Society written by Mr. Yogesh Pathak. It introduces in brief the articles in this issue which focus on Man-Nature Relationship.
Vegetation character and species diversity of the Panshet Catchment
Authors: Gindi Revati , Amritkar Kirti , Mahajan Gunwant , Satpute Trupti
Published: October 2021

The present note elaborates the vegetation character and plant diversity in the Panshet Dam Catchment,studied during six months of field survey in 2014 (July-December) as part of a project undertaken byEcological Society and supported by Global Forest Watch.As floral species are directly related to climatic type, especially rainfall, therefore the Panshet catchmentwas divided into high, medium and low rainfall zones. The floral species survey was conducted in relationwith these zones.The focus of present study was to relate species composition with physical factors like altitude andclimate. To study the vegetation character of the catchment, species level surveys of various vegetationcategories like tall canopy forests, devrais, shrubbery and others, were undertaken and the speciescomposition of each vegetation category was recorded. Moreover, species occurrence over rainfall zones wasrecorded. Identification of rare, endemic and specialist species was equally important to gauge thevegetation character and ecological value. Other observations included dominant species and invasivespecies.
Effectiveness of planned teaching programme on knowledge of school going children regarding Dengue Fever in a selected Government School, Ankoli, Berhampur, Ganjam, Odisha
Authors:   Odisha, India, Nayak Sasmita
Published: October 2021

Background: Dengue is a very significant world public health problem which has largely been ignored in the developed world. Objectives : To find out the effectiveness of planned teaching programme on knowledge of school going children regarding dengue fever and find the association between posttest knowledge scores with their selected demographical variable. Methods: Data were collected from fifty school going children selected through simple random sampling technique, by using self-structured questionnaire from 17.4.2017 to 2.5.2017. Results: Highest percentages (50%) of the school children were in 11-12 years of age group. 56% of them were female. 62% of them were studying in sixth class. The overall pre-test mean knowledge score was 10.02±4.04 which was 29.47% of the total score whereas in post-test it was 25.24 ± 5.00 which was 74.23% and effectiveness was 44.76%. Further highly significant (p<0.05) difference was found between pre and post-test knowledge score whereas no significant (p<0.05) association was found between post-test knowledge score and all the selected demographic variable of the school going children revealing effectiveness of planned teaching programme. Conclusion: Findings of the study revealed that the knowledge of the school going children regarding dengue fever and its prevention were less before the introduction of PTP. Hence it can be concluded that PTP was an effective strategy for providing information and to improve knowledge of school going children regarding dengue fever. and this PTP can be utilized in creating awareness programme in prevention and control of dengue fever.
The Development of Thinking Skills for the Future of Hospitality Industry in India
Authors:   NA, Assotikar Harsha
Published: October 2021

Thinking skill in the hospitality industry in the modern day is the focal point which is missed in many students. The students are been taught in India from early schooling to memorization which has little time for the development of thinking skills, which fails to address the deeper understanding and overall learning experience. Learning to raise a suitable question to the problem and presume information in order to construct a better association with the information is also crucial. This research paper highlights on exploring the possibility of guiding student’s thinking skill abilities in hospitality school to include the opportunity for progressive learning. The prospective students of hospitality should be encouraged to combine an ethical and monetary element in their later business practices. The intention of this research is to recognize the bridge in understanding, enumerate their capability to compose their knowledge of the material, and for the hospitality students to realize the material sufficient to create a perceptive question showcasing their understanding of the material. A secondary aspect of this research thinking skill ability will give better opportunity to the students to prosper in the hospitality industry.
ԻՐԱՎՈՒՆՔԻ ԵՎ ԱՐԴԱՐՈՒԹՅԱՆ ՓՈԽՀԱՐԱԲԵՐԱԿՑՈՒԹՅՈՒՆԸ / THE INTERRELATIONSHIP BETWEEN LAW AND JUSTICE
Authors: Galstyan L.
Published: October 2021

Հոդվածը նվիրված է «արդարություն» և «իրավունք»
կաեգորիանների փոխհարաբերակցության խնդրին: Արդարության
խնդրի քննարկումը ամենահներից մեկն է ինչպես փիլիսոփայության,
այպես էլ իրավագիտության համար: Պատմության ընթացքում
արադարության մոտեցումնները նշանակալից են եղել ինչպես
փիլիսոփանների, այնպես էլ իրավաբանների համար: Հոդվածն
ուսումնասիրում է պատմության տարբեր փուլերում գոյություն ունեցող
հիմնական հասկացությունները, վերլուծում փիլիսոփայական և
իրավական համայնքների տեսակետները և դրանց փոխազդեցությունը:
Իրավագիտության մեջ արդարադատությունը հանդես է գալիս որպես
կանոնների ձևավորման, պետության գործողությունների և
օրենսդրության կանոնների կիրառման սկզբունք: / The paper deals with the issues of justice and law. The justice discourse is one of the oldest for both philosophy and the legal science. Approaches to the category of justice have been indicated throughout the history by both philosophers and legal scholars. The paper examines the basic concepts that existed at different stages of history, analyzes the views of philosophical and legal communities and their mutual influence. In jurisprudence, justice is
positioned as a principle of rule-making, State action and law rules application.
ՀԱՅԿԱԿԱՆ ԵՎ ԳԵՐՄԱՆԱԿԱՆ ՄԵԿԱԿԱՆ ՀԵՔԻԱԹԻ ԶՈՒԳԱԴՐԱԿԱՆ ՎԵՐԼՈՒԾՈՒԹՅՈՒՆ / COMPARATIVE ANALYSIS OF THE ARMENIAN AND GERMAN FAIRY TALE
Authors: Adamyan N.
Published: October 2021

Աշխատանքում ներկայացված է սյուժետային նմանություն ունեցող հայկական ու գերմանական մեկական հեքիաթների զուգադրական համեմատական վերլուծություն՝ արևելյան և արևմտյան քաղաքակրթությունների, հասարակական մտածողության տարբերությունների լույսի ներքո: / In this paper, we present a comparative analyis of an Armenian and a German fairy tales which share common aspects of their plots, showing how they reveal the similarities and differences between Eastern and Western civilizations.
ԶՄՅՈՒՌՆԻԱՅԻ «ՀՈՄԵՐ» ԹԻՎ 806 ՕԹՅԱԿԻ ԵՐԵՎԵԼԻ ԴԵՄՔԵՐԸ / THE PROMINENT FIGURES OF "THE HOMER‘‘ 806 LODGE IN SMYRNA
Authors: Movsisyan F.
Published: October 2021

Ղրիմի (Արևելյան) պատերազմի ավարտից հետո եվրոպական մեծ
տերությունների հարկադրանքով սուլթան Աբդուլ Մեջիդ I-ի շնորհած
«Հաթթը հյումայուն» հրովարտակը «Թուրքիան եվրոպականացնելու» և
բարեփոխումներ իրականացնելու միտում ուներ: Դրանից ոգևորված՝ մի
խումբ զմյուռնահայ մտավորականներ իրենց ազգային, հասարակական
և կրոնական գործերը բարելավելու նպատակով ստեղծեցին տարբեր
ընկերություններ ու միություններ, անդամագրվեցին Անգլիայի և
Ֆրանսիայի ազատ որմնադիրների հիմնած մասոնական օթյակներին:
1859թ. նոյեմբերի 19-ին Զմյուռնիայում «Անգլիայի Մեծ Օթյակի»
արտոնագրով հիմնված անգլախոս «Հոմեր» («Homer») թիվ 806 օթյակը
շուրջ երեք տասնամյակ արգասաբեր գործունեություն է ծավալել
արևմտահայության շրջանում մասոնության գաղափարների
տարածման ուղղությամբ: Օթյակի երևելի դեմքերից էին անգլիացի
նշանավոր մասոն Հայդ Քլարքը, արևմտահայ մասոնության ռահվիրա
Սերովբե Ազնավուրը, վաճառական Միքայել Երամյան, դրամատուրգ,
բանասեր Սարգիս Վանանդեցին և ուրշներ: «Հոմեր» օթյակի անդամները
1861թ. մարտի 31-ին Զմյուռնիայում հիմնեցին ֆրանսախոս
«Հաղթանակ» («La Victoire»),իսկ 1864 թ. ապրիլի 29-ին՝ «Տիգրան» թիվ
1014 հայկական առաջին օթյակը: «Հոմեր» օթյակն իր աշխատանքը
դադարեցրել է 1887թ. փետրվարի 15-ին՝ Զմյուռնիայում տեղի ունեցած
քաղաքական իրադարձությունների պատճառով: / After the Crimean War under compulsion of the great European states, the ―Hatt Hyumayun‖ manifesto, granted by Sultan Abdul Mejit 1st, tended to ―Europeanize Turkey‖ and make reforms. A group of Armenian
intellectuals in Smyrna inspired by that document created different
associations to improve their national, public and religious affairs and admitted
to the English and French masonic lodges. On November 19,1859,
―The Homer‖ 806 Lodge, founded by the license of ―The Great Lodge of
England‖, promoted activity among Western Armenians (about three
decades) to disseminate masonic ideas. The eminent figures of the Lodge were the famous English mason Hyde Clarke, the well-known Western- Armenia masonic leader Serovbe Aznavour, vendor Michael Eramyan, playwright, philologist Sargis Vanandetsi and the like. On March 31, 1861, the members of ―The Homer‖‘ Lodge founded the
francophone ―La Victoire‖ in Smyrna, and the 1st Armenian lodge ―Tigran‖
1014 - on April 29, 1864. The lodge ―Homer‖ stopped its activity on
February 15,1887 because of the latest political developments in Smyrna.
HEPATOPORTAL HEMODYNAMICS IN PATIENTS WITH ACUTE DECOMPENSATION OF HEART FAILURE
Authors: Gulyamova K , Alimov D
Published: October 2021

The aim of the study. To study the features of hepatoportal hemodynamics in patients with acute decompensated heart failure.Material and methods. The study included 138 patients with chronic heart failure admitted to the RRCEM due to the development of acute decompensation of heart failure. The average age of the patients was 66.02 ± 10.41 years. As a control group, the study included 20 healthy volunteers of the corresponding age. During hospitalization, all patients were assessed for the structural and functional state of the left and right heart, as well as the characteristics of the hepatic and pulmonary blood flow.Results. In patients with acute decompensation of heart failure, the hepatic artery was characterized by an increase in its diameter (p <0.001), the resistance index significantly exceeded the indicator recorded in healthy volunteers (p <0.001), which reflects the presence of portal hypertension. The study of hemodynamics in the portal vein revealed an increase in the diameter of the vein (p <0.05) and an acceleration of the volumetric blood flow velocity (p <0.001). At the same time, the pulsation index was increased (p <0.001), which is typical for a change in the flow profile against the background of right ventricular chronic heart failure. Signs of portal hypertension were recorded in the study of blood flow in the splenic artery: its diameter, linear and volumetric blood flow velocity were increased (p <0.001 for artery diameter and volumetric blood flow velocity and p <0.01 for linear blood flow velocity).Conclusion. In patients with acute decompensated heart failure, in addition to impaired systolic function of the left ventricle, there is a significant violation of hepatoportal hemodynamics with the development of portal hypertension, a decrease in arterial hepatic blood flow and obstruction of hepatic venous outflow with signs of fibrotic changes in the hepatic parenchyma. The degree of change increases with a decrease in the left ventricular ejection fraction.
COST-EFFECTIVE MODEL OF SCREENING FOR TYPE 2 DIABETES IN THE REPUBLIC OF UZBEKISTAN
Authors: Alimov A , Khaidarova F , Ismailov S , Rakhimova G , Nazhmutdinova D , Shagazatova B , Pakhomov Ya , Alieva A , Tsareva V
Published: October 2021

Epidemiological studies revealed up to 5-6 undiagnosed cases of type 2 diabetes mellitus (DM2) per 1 registered patient. The late diagnosis of DM2 presents a medical and socio-economic problem. Aim. To identify the most cost-effective, easy-to-use method for regular screening for DM2 in primary care settings in the Republic of Uzbekistan. Material and methods. 4 diabetes screening scenarios differing in the inclusion criteria (age 45 vs age 45 plus arterial hypertension plus obesity), and screening methods (testing for glycemia and/or HbA1c) were studied in urban and rural primary care polyclinics among 2430 people. Results. In primary health care real clinical practice, the most cost-effective and easy-to-follow strategy for active screening for DM2 is testing for random glycemia using a certified glucometer, in any resident aged 45 or older visiting his/her GP for any reason. If test results are intermediate, the person is called again the next day for fasting glycemia testing to confirm the diagnosis. If the test results are normal, the person is given recommendations of healthy lifestyle and re-testing in 1 year. If the test result corresponds to DM, the person is referred to a local endocrinologist.
MODERN SURGICAL APPROACHES TO THE TREATMENT OF COMBINED ATHEROSCLEROTIC DAMAGE OF THE CORONARY AND CAROTID ARTERIES
Authors: RAKHIMOVA R , ALIMOV D
Published: October 2021

The number of patients with brachiocephalic artery disease and coronary artery disease (CHD) is steadily increasing. Despite the achieved results in the surgical treatment of patients with lesions of the brachiocephalic arteries and concomitant coronary artery disease, the world has not yet reached a consensus on the tactics of treating this group of patients. Most patients with concomitant coronary and carotid artery disease have a combination of two or more risk factors for neurological complications. In addition, for elderly patients, the time of artificial circulation and the duration of the operation are of decisive importance. An increase in this time is inevitable with a single-stage surgical operation. Carotid endarterectomy or carotid stenting is indicated before or simultaneously with coronary artery bypass grafting in symptomatic patients with 80% carotid stenosis (LE: C). However, until data from randomized clinical trials are available, the surgical approach to patients with severe coronary and carotid lesions will be individualized, based on the specific risk level of each patient and the experience of the institution.
ESTIMATION OF THE EFFECTIVENESS OF ASSOCIATED ANESTHESIA BASED ON EPIDURAL BLOCKADE IN CESARIAN SECTION IN PATIENTS WITH «EVIDENT» MITRAL STENOSIS
Authors: Muminov A , Matlubov M , Tarayan S , Nishanova F , Ilxamov A
Published: October 2021

aim. To assess the efficacy and safety of general associated balanced anesthesia based on epidural block during cesarean section in patients with “severe” mitral stenosis.Material and methods. The results of clinical observations, and a complex of clinical, functional and biochemical studies during cesarian section of 26 women aged 18-30 years, with a gestation period of 32-34 weeks had been studied. All patients had «severe» MS (according to A.N. Okorokov, s classifications). Depending on the method of anesthesia all patients were divided into two equal groups Patients of group I (n=13) were operated under conditions of associated balanced anesthesia (CBA) on the basis of epidural blockade (EB) patients of group II (n=13) were operated under conditions of one of the most common variants of multicomponent anesthesia (MCA). The operations were performed in a planned method, their durations made 35-60 minutes. The duration of anesthesia were 50-110 minutesResults. Significant advantages of CBA on the basis of EB became apparent: minimal expense of narcotic preparations and muscular relaxants: rapid rehabilitation of reflex muscular activity, making it possible to carry out extubations of trachea in earlier term: opportunity of using epidural catheter in postoperative period in order to receive prolonged postoperative analgesia. Conclusion. CBA on the basis of EB provides reliable antinociceptive protections of the body from surgical aggression, ensures a smooth course of anesthesia and early postoperative period and therefore has an obvious advantage over the traditional version of GMCA with AVL.K
CHANGES OF THE CYTOKINE PROFILE DEPENDING ON THE SEVERITY OF ENDOGENOUS INTOXICATION IN MECHANICAL JAUNDICE
Authors: Aripova T , Aripova N , Matmuradov S , Babadzhanov J
Published: October 2021

Aim. Study of the reaction of the cytokine pofil to the severity of the course of endogenous intoxication in patients with obstructive jaundice.Material and methods. The study involved 84 patients with obstructive jaundice (MJ) caused by malignant tumors of the biliopancreatoduodenal zone (BPDZ). There were 55 men (65.5%), women - 29 (34.5%). The average age of the patients was 59.1 ± 2.3 years. The severity of endogenous intoxication and the cytokine profile of patients with breast cancer were assessed by determining the concentration of medium molecular peptides (MMP) and proinflammatory cytokines TNF-α and IL-6 in blood plasma and bile.Conclusion. In patients with breast cancer of tumor genesis, there is a multiple increase in the concentration of proinflammatory cytokines in blood serum and bile. There is also a manifold increase in apoptosis indices of blood lymphocytes and the content of MMP. Adequate and timely decompression of the biliary tract in breast cancer ensures the elimination of factors that cause endogenous intoxication and an increase in the inflammatory process, which makes it possible to prepare the patient for the second stage of radical surgical treatment after of the aplication of a percutaneous-transhepatic cholangiostomy.
Pengaruh Sistem Bagi Hasil Terhadap Minat Nasabah Pada Tabungan Mudhrabah Bank Syariah Indonesia Cabang Veteran Makassar
Authors: Sugeng Rachmat , Fadillah Nur
Published: October 2021

Penelitian ini bertujuan untuk mengetahui pengaruh sistem bagi hasil terhadap minat nasabah pada tabungan mudrabah pada bank syariah Indonesia cabang Makassar dengan menggunakan pendekatan kuantitatif. Pengambilan sampel menggunakan rumus Slovin sehingga sampel yang diambil sebanyak 99 responden. Pengumpulan data dilakukan dengan menyebarkan kuesioner online. Pengukuran data menggunakan skala Likert 5 poin untuk mengukur 6 indikator. Teknik analisis yang digunakan adalah regresi linier sederhana. Berdasarkan penelitian ini menunjukkan bahwa variabel Sistem Bagi Hasil (X) dan Minat Pelanggan (Y) berpengaruh positif dan signifikan.
Pengaruh Pendapatan Asli Daerah, Dana Alokasi Umum dan Dana Alokasi Khusus terhadap Alokasi Belanja Daerah Pada Kab/Kota Sumatera Utara
Authors: Fitri Fitri Dewi Sartika Ritonga , Dewi Ratna Sari
Published: October 2021

Penelitian ini bertujuan untuk mengetahui pengaruh Pendapatan Asli Daerah, Dana Alokasi Umum dan Dana Alokasi Khusus terhadap Alokasi Belanja Daerah baik secara simultan maupun parsial pada pemerintahan kabupaten/kota di Provinsi Sumatera Utara. Metode penelitian dalam skripsi ini adalah menggunakan penelitian Kuantitatif, dengan jumlah sampel 33 Kabupaten/Kota yang ada di Provinsi Sumatera Utara. Penelitian ini dilakukan untuk periode 2018-2019. Jenis data yang digunakan adalah data sekunder. Data diperoleh melalui situs internet (www.bps.go.id) dan situs Badan Pusat Statistik Sumatera Utara. Data yang dianalisis dalam penelitian ini diolah dari Laporan Realisasi Anggaran Pendapatan dan Belanja Daerah (APBD) Kabupaten/Kota Sumatera Utara. Data yang telah dikumpulkan dianalisis dengan metode analisis data yang terlebih dahulu dilakukan pengujian asumsi klasik sebelum melakukan pengujian hipotesis. Pengujian hipotesis dalam penelitian ini menggunakan regresi linier berganda dengan uji F dan uji t. Hasil penelitian menunjukkan bahwa secara simultan Pendapatan Asli Daerah, Dana Alokasi Umum dan Dana Alokasi Khusus berpengaruh positif dan signifikan terhadap Alokasi Belanja Daerah. Secara parsial Pendapatan Asli Daerah, Dana Alokasi Umum dan Dana Alokasi Khusus berpengaruh positif dan signifikan terhadap Alokasi Belanja Daerah.
Pengaruh Kompetensi Aparat Desa Dan Partisipasi Masyarakat Terhadap Akuntabilitas Pengelolaan Dana Desa Di Kecamatan Namorambe Kabupaten Deli Serdang
Authors: Pratiwi Putri Indah , Dewi Ratna Sari
Published: October 2021

Tujuan penelitian ini adalah untuk mengetahui dan menguji pengaruh kompetensi aparat desa dan Partisipasi Masyarakat terhadap akuntabilitas pengelolaan dana desa di Kecamatan Namorambe Kabupaten Deli Serdang. Adapun populasi dalam penelitian ini adalah seluruh desa yang berada di Kecamatan Namorambe dengan responden yang terdiri atas Kepala Desa, Sekretaris Desa, Bendahara Desa dan Badan Permusyawaratan Desa (BPD). Jenis penelitian ini adalah penelitian kuantitatif. Metode pengambilan sampel dilakukan dengan menggunakan sampel jenuh. Teknik pengumpulan dilakukan dengan menggunakan kuisoner dengan cara disampaikan langsung kepada responden. Teknik analisis data menggunakan teknik analisis statistik deskriptif dan menggunakan Regresi Linier Berganda. Dari hasil penelitian yang dilakukan menunjukkan bahwa terdapat pengaruh kompetensi aparat desa dan partisipasi masyarakat terhadap akuntabilitas pengelolaan dana desa.
Analisis Perbandingan Model Springate Dan Model Zmijewski Dalam Mengukur Tingkat Kesehatan Perusahaan Pada PT. Bintang Persada Satelit
Authors: Ambarwati Kiki Fatimah , Sriwardany
Published: October 2021

Penelitian ini bertujuan untuk mengetahui dan menganalisis perbandingan model Springate dan Zmijewski dalam memprediksi tingkat kesehatan perusahaan PT. Bintang Persada Satelit periode 2018- 2020 dan untuk mengetahui model prediksi manakah yang paling akurat. Sampel yang digunakan dalam penelitian ini adalah 36 laporan keuangan PT. Bintang Persada Satelit periode 2018- 2020. Teknik pengambilan sampel ditentukan dengan metode purposive sampling. Jenis data yang digunakan adalah data sekunder dengan pengumpulan data menggunakan metode dokumentasi dan studi kepustakaan. Teknik analisis data yang digunakan adalah Uji Kruskal-Wallis H dan Uji Tingkat Akurasi. Hasil dari penelitian ini menunjukkan terdapat perbedaan yang nyata antara model Springate  dan Zmijewski, dan Springate dengan menggunakan Uji Kruskal-Wallis H. Model prediksi yang paling akurat dalam memprediksi kebangkrutan PT. Bintang Persada Satelit adalah Zmijewski dengan tingkat akurasi 100%.
The self-selected use of social media for the pre-registration student nurse journey: An interpretative phenomenological analysis
Authors: Hayward Melanie
Published: October 2021

Objective: To explore the lived experience of the phenomenon of self-selected social media use through the viewpoint of UK pre-registered student nurses in relation to their studies.Methods: Seven UK pre-registration student nurses who used social media in relation to their nursing studies were interviewed during February and March 2020. Semi-structured interviews were transcribed and analysed using interpretative phenomenological analysis.Results: Four themes indicated that students used social media to discover, create and control their ‘own space’ for personal and professional benefit, through a ‘whole new world’ of social connections, ‘opening doors’ for learning and development to support themselves and each other on their ‘journey to be nurses’. The analysis also revealed an inherent journey of self-discovery affording self-empowerment and resilience, the significance of which was dependent on each participant’s characteristics and experiences.Conclusions: Social media use may have the potential to assist student nurse decisions related to, enhance the experience of, and engagement in, their education. As an international phenomenon, social media could be considered as an agent to improve student nurse retention and facilitate recruitment. Future research is recommended to explore the use of social media in this way as well as the challenges to its use.
Statistik Penjualan Tiket Melalui Diksi Dalam Pelayanan Penumpang Sistem Online Pada Pt. Dharma Lautan Cabang Utama Banjarmasin Selama Pandemi Covid-19
Authors: Desy Hidayati , Juhrani Juhrani , Rosariasanti Irnita
Published: October 2021

Penelitian ini bertujuan untuk (1) Untuk mengetahui bagaimana Statistik penjualan tiket online pada PT. Dharma Lautan Utama Cabang Banjarmasin selama Pandemi Covid 19. (2) Untuk mengetahui jenis diksi yang dipergunakan pada pelayanan penjualan tiket kapal penumpang sistem online pada PT. Dharma Lautan Utama Cabang Banjarmasin. Penelitian ini termasuk jenis penelitian kualitatif yang bersifat deskriptif yaitu sebagai prosedur penelitian yang menghasilkan data deskriptif berupa kata-kata tertulis atau lisan dari orang-orang dan perilaku yang diamati dengan tujuan untuk mendeskripsikan diksi yang digunakan pada pelayanan penjualan tiket online pada PT Dharma Lautan Utama Cabang Banjarmasin. Berdasarkan hasil penelitian selama pandemi ini PT Dharma Lautan Utama cabang Banjarmasin mengalami penurunan jumlah penumpang sehingga penjualan tiket pun juga mengalami penurunan.  Pada penggunaan yang ditemukan yaitu pada kata kongkret tersebut hal yang dilakukan pada saat interkasi baik di luar kantor maupun di dalam, pada kejadian berupa wawasan dan informasi maka, ada bukti yang dibocarakan berdasarkan pada hasil survey serta tindakan, salah satunya pada saat pelayanan penjualan tiket kapal penumpang melalui onlien, ada hal yang dilihat dari segi kasus salah satunya adalah adanya pandemi covid, dengan demikian, hal yang dilakukan adalah pelayanan melalui onlie, hal ini berutjuan untuk tetap meningkatkan pelayanan, serta jalur transfortasi melalui tiket online tersebut., hal tersebut justru dengan bahasa kongkrit menyesuaikan dengan keadaan pada pelayanan tiket online demi kenyamaanan calon para penumpang. Jenis kata kongkret yang dituturkan oleh pegawai di PT Dharma Lautan cabang Banjarmasin sesuai pada kejadian, kasus, suasana dan kadang melonjaknya tiket pada saat musim tertentu. Dengan demikian diksi pada kata kongkret yang ditumbulkan pun menjadi salah satu informasi untuk para penumpang. kata umum merupakan kata sebagai cakupan arti yang luas yang mana kata tersebut sering dipakai oleh masyarakat pada umumnya.
Alur Kepengurusan Dokumen Rencana Kegiatan Bungkar Muat (Rkbm) Oleh PT. Kalimantan Mandiri Sukses Banjarmasin
Authors: S Firdaus , S Mini , S Uni
Published: October 2021

Penelitian ini bertujuan untuk mendeskripsikan alur pengurusan Dokumen Rencana Kegiatan Bongkar Muat (RKBM). Penelitian ini termasuk jenis penelitian kualitatif yang bersifat deskriptif yaitu sebagai prosedur penelitian yang menghasilkan data deskriptif berupa kata-kata tertulis atau lisan dari orang-orang dan perilaku yang diamati. Dengan demikian, Pemuatan di mother vessel (MV) atau kapal induk menyangkut  berbagai aspek tentang bagaimana cara melakukan persiapan dan pemuatan diatas kapal baik dalam hal persiapan logistik maupun persiapan dokumen rencana kegiatan bongkar muat yang diajukan ke kantor kesyahbandaran dan otoritas pelabuhaan (KSOP) oleh PT. Kalimatan Mandiri Sukses Banjarmasin selaku perusahaan bongkar muat. Namun dalam kenyataan aspek-aspek tersebut belum dapat terlaksana dengan baik, sehingga akan berdampak kerugian pada perusahaan pelayaran dan pemilik muatan, usaha bongkar muat barang dari kapal ke kapal, yang merupakan terdiri dari kegiatan bongkar muat, pengaturan muatan dan penerimaan/pengiriman.
Kriminologisen rekisteritutkimuksen kehityssuuntia Pohjoismaissa
Authors: Aaltonen Mikko
Published: October 2021

Rikollisuutta koskevien rekisteriaineistojen tutkimuskäyttö on lisääntynyt 2000-luvulla voimakkaasti Pohjoismaissa ja myös Suomessa. Kriminologisen tutkimuksen mahdollisuudet ovat parantuneet rekisterilinkkausaineistojen aikaisempaa paremman saatavuuden myötä, ja erityisesti Tilastokeskuksen etäkäyttöjärjestelmä FIONA:n perustaminen on ollut tärkeä uudistus. Rekisteriaineistoja on hyödynnetty viime vuosina sekä rikollisuuden syiden että rikosseuraamusten vaikutusten pohjoismaisessa tutkimuksessa varsin monipuolisesti. Yksilötasoisilla pitkittäisaineistoilla päästään kiinni huomattavasti aggregaattitilastoja tarkempaan rikollisuuden muutosten analyysin ja niitä voidaan hyödyntää aikaisempaa uskottavammassa kausaalivaikutusten tutkimuksessa. Luonnollisten koeasetelmien ja kvasikokeellisten tutkimusmenetelmien kehitys on hyödyttänyt rekisteritutkimusta selvästi ja nostanut osaltaan rekisteriaineistojen käyttöarvoa.

Kirjoitus perustuu 14.12.2020 pidettyyn Veli Verkko -luentoon.
Pentingnya Pengukuran Pupil Distance (PD) Secara Tepat Untuk Menjaga Akurasi Distance Vitror (DV) Kacamata
Authors: Toma Toma , Rizki Abdillah Bunyamin , Marlina Simarmata Murni
Published: October 2021

Pupil Distance (PD)  is measured in millimetres and even a slight variation can cause a number of vision and eye health problems due to inacurately fitting of Distance Vitror (DV). PD must be paralel to DV, therefore  PD measurements must be committed throughtly. It requires comprehensive knowledge and technical skill. With the popularity of buying glasses online, a number of websites have come up with do-it-yourself measurements or apps that will take this measurement for you. The problem is that these are not scientifically accurate measurements and are not being performed by professionals. There is a large margin of error and buyers could end up with glasses that hurt their vision—not correct it.This research is aimed to show ideal procedure that must be committed in producing glasses to avoid inacurate PD measurement. The researcher uses library aprroach to gain related data and informations, then discuss the problem and solution in descriptive approach.
Pengaruh Diabetes Melitus Terhadap Mata
Authors: Sumiyati Sumiyati , Umami Nisa Zakiati , Marlina Simarmata Murni
Published: October 2021

Eyes are the window to life. Eyes are the most important and very meaningful sense that a person has. The eyes are the sense of sight that can be used to carry out daily activities. However, if someone's vision is disturbed, their activities will be disturbed. Many things can affect the quality of vision, one of which is diabetes mellitus. Diabetes mellitus can cause damage to the function of the eye and retina. Examples of diabetes mellitus in the eye are diabetic retinopathy, gaucoma and cataracts.
Pengaruh Kekontrasan Optotype Snellen Terhadap Tajam Penglihatan Pada Pemeriksaan Refraksi Subjektif
Authors: Budiana Wahyu , Nugraha Opep Cahya , Efendi Zakaria
Published: October 2021

The visual acuity examination is affected by the contrast between the background of the optotype used and the letter. Changes in contrast result in unstable visual acuity and affect the examination results subjectively. The writing of this paper uses a descriptive method using a variety of literature data, one of which is by David Cline, John R. Hofstetter and Henry W., Griffin, with the title. Dictionary Of Visual Science, Fourth Edition which explains that contrast in Snellen's optotype affects visual acuity.
Faktor-Faktor yang Berhubungan dengan Kinerja Karyawan Rumah Sakit
Authors: Hartutik Wiwit
Published: October 2021

Introduction: Hospital employee performance as the spearhead of health services is a very important issue to be studied in order to maintain and improve the quality of health services. The purpose of this study was to determine the relationship between leadership style, work discipline, and compensation on employee performance at the pathology installation of the Gatot Soebroto Army Hospital in 2019.

Methods: Using quantitative research with Cross Sectional approach. The sample uses a total sampling of 40 respondents. The instrument of this research used a questionnaire.

Results: Relationship between work discipline factors (Pvalue = 0.027; OR = 5,844) and compensation factors (P value = 0,018; OR = 7,111) with employee performance in the anatomical pathology installation of Gatot Soebroto Hospital in 2019. While the leadership style factor (P value = 0,800) does not relate.

Discussion: Two of the three variables studied were related to employee performance, namely: work discipline and compensation. While one other variable, namely leadership style is not related to employee performance.
Faktor-Faktor yang Berhubungan dengan Keputusan Klaim Asuransi Kesehatan Kumpulan PT. SGMW Motor Indonesia pada Pialang Asuransi PT. Cipta Integra Duta
Authors: Hasan Wawa Wardil
Published: October 2021

Introduction: Commercial health insurance companies can cater to the diverse desires of individuals. However, as a consequence, the company will design various products according to public demand with certain terms and conditions in the policy. This study aims to determine the factors associated with the insurance claim decision of the group of PT. SGMW Motor Indonesia at Insurance Broker PT. Cipta Integra Duta 2020.

Methods: This analysis uses independent submission variables that are claimed from completely rejected claims, accepted and claimed claims in their entirety and the dependent variable is insurance membership status, completeness of files, over-limit claims, health insurance benefits, non-original claim documents and resources. analysis of claims and insurance guarantee letters. This research data was obtained from secondary data in the form of claim data from PT SGMW Motor Indonesia for the period of coverage from January 1, 2020 to December 31, 2020 as an accumulation of the results of the analysis of claims from the insurer PT. International Services Pacific Cross with a total sample of 7,123. Statistical method using non-parametric comparative test analysis was performed on two variables using the Chi Square method.

Results: The factors that were most related to the decision that were claimed in whole and claimed to be partially accepted were the health insurance benefits factor with a p value of 0.001 and human resource analysis claims with a p value of 0.000.

Discussion: Therefore, it is necessary to improve the quality of human resources for claims analysts who work in the health insurance sector either by training, certification, seminars and periodic socialization, as well as socializing insurance benefits and advocating for insurance companies suspected of fraud in their claims analysis, so that public trust in insurance is needed, can grow.
Peran Ibu dalam Pendidikan Kesehatan Reproduksi, Peran Bidan, Personal Hygine Menstruasi terhadap Kejadian Keputihan pada Remaja Putri
Authors: Reza Chesi Ramadani
Published: October 2021

Introduction: Flour albus is a symptom disorders of the reproductive organs often experienced by most women, according to WHO (World Health Organization) 75% of women in the world will experience vaginal discharge at least once in a lifetime and as many as 45% will have 2 or more. This study aims to determine the relations of mother's role in reproductive health education, role of midwife, personal hygine menstruation of the teenage girl flour albus event in class VIII and IX at SMP Muhammadiyah 35 Jakarta

Method: This research method uses quantitative research with a cross sectional approach. The study sample used total sampling, namely all the teenage girl in class VIII and IX were 50 people

Result: The results showed that there was a relationship between the mother's role in reproductive health education variable and the p-value of 0.003, the role of midwife variable with the result of p-value 0.001 and the variable personal hygine menstruation with a p-value of 0.015 for the teenage girl flour albus event.

Discussion: 34 young women who experience vaginal discharge, 27 young women whose mothers do not play a role in health education, 27 young women who do not get the role of a midwife and 32 young women who are not good at performing menstrual personal hygiene. and there is a relationship between the role of mothers in reproductive health with the incidence of vaginal discharge in adolescent girls. In conclusion, it is expected the school to cooperate among parents and health officer, for the reproductive health education, to improve the degree of health and build good reproductive health behaviour, as well as to preventing and handling vaginal discharge in teenage girl.