bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating psychosocial variables and societal diversity in epidemic models for predicting COVID-19 transmission dynamics
Authors: Jirsa Viktor K. , Petkoski Spase , Wang Huifang , Woodman Marmaduke , Fousek Jan , Betsch Cornelia , Felgendreff Lisa , Bohm Robert , Lilleholt Lau , Zettler Ingo , Faber Sarah , Shen Kelly , Mcintosh Anthony Randal
Published: August 2022

During the current COVID-19 pandemic, governments must make decisions based on a variety of information including estimations of infection spread, health care capacity, economic and psychosocial considerations. The disparate validity of current short-term forecasts of these factors is a major challenge to governments. By causally linking an established epidemiological spread model with dynamically evolving psychosocial variables, using Bayesian inference we estimate the strength and direction of these interactions for German and Danish data of disease spread, human mobility, and psychosocial factors based on the serial cross-sectional COVID-19 Snapshot Monitoring (COSMO; N = 16,981). We demonstrate that the strength of cumulative influence of psychosocial variables on infection rates is of a similar magnitude as the influence of physical distancing. We further show that the efficacy of political interventions to contain the disease strongly depends on societal diversity, in particular group-specific sensitivity to affective risk perception. As a consequence, the model may assist in quantifying the effect and timing of interventions, forecasting future scenarios, and differentiating the impact on diverse groups as a function of their societal organization. Importantly, the careful handling of societal factors, including support to the more vulnerable groups, adds another direct instrument to the battery of political interventions fighting epidemic spread.
Diversity and determinants of recombination landscapes in flowering plants
Authors: Brazier Thomas , Glémin Sylvain
Published: August 2022

During meiosis, crossover rates are not randomly distributed along the chromosome and their location may have a strong impact on the functioning and evolution of the genome. To date, the broad diversity of recombination landscapes among plants has rarely been investigated and a formal comparative genomic approach is still needed to characterize and assess the determinants of recombination landscapes among species and chromosomes. We gathered genetic maps and genomes for 57 flowering plant species, corresponding to 665 chromosomes, for which we estimated large-scale recombination landscapes. We found that the number of crossover per chromosome spans a limited range (between one to five/six) whatever the genome size, and that there is no single relationship across species between genetic map length and chromosome size. Instead, we found a general relationship between the relative size of chromosomes and recombination rate, while the absolute length constrains the basal recombination rate for each species. At the chromosome level, we identified two main patterns (with a few exceptions) and we proposed a conceptual model explaining the broad-scale distribution of crossovers where both telomeres and centromeres play a role. These patterns correspond globally to the underlying gene distribution, which affects how efficiently genes are shuffled at meiosis. These results raised new questions not only on the evolution of recombination rates but also on their distribution along chromosomes.
COVID-19 orphans—Global patterns associated with the hidden pandemic
Authors: Lowe Callum , Rachmawati Leli , Richardson Alice , Kelly Matthew
Published: August 2022

Whilst the COVID-19 pandemic has caused significant mortality across the globe, many children have been orphaned due to the loss of their parents. Using the framework of an ecological analysis, we used estimates of total maternal/paternal orphans using an online COVID-19 orphanhood calculator to estimate the total orphans per COVID-19 death for 139 countries. Descriptive statistics were used to determine global patterns behind this risk of children being orphaned. Linear regression models were fitted to determine factors associated with this risk, and the association with vaccination coverage was calculated. We found that there is tremendous global variation in the risk that COVID-19 deaths will lead to orphaned children, and that this risk is higher in countries below median GDP per capita (1·56 orphans per deaths) compared to countries above (0·09 orphans per death). Poverty prevalence (B = 2·32, p<0·01), GDP per capita (B = -0·23, p<0·05), and a greater proportion of people with NCDs being reproductive aged (B = 1·46, p<0·0001) were associated with this risk. There was a negative correlation between 2nd dose vaccination coverage and orphans per death (p<0·05). The risk of children being orphaned per COVID-19 death, alongside fertility rate, is due to there being a greater share of COVID-19 deaths among younger persons. This is more likely in poorer countries and those where the age distribution for non-communicable diseases that elevate COVID-19 mortality risk are more uniform. Due to vaccine coverage inequity, more children will suffer the loss of their parents in poorer countries.
Identifying interventions to reduce peripartum haemorrhage associated with caesarean delivery in Africa: A Delphi consensus study
Authors:   APORG Caesarean Delivery Haemorrhage Group
Published: August 2022

Women in Africa are fifty times more likely than in high-income settings to die following caesarean delivery, and peripartum haemorrhage is most strongly associated with mortality. We aimed to establish consensus on which interventions are considered most feasible to implement and most effective at reducing haemorrhage associated with caesarean delivery across Africa. We conducted a Delphi consensus study, including obstetric and anaesthesia providers from across Africa. In round one the expert group proposed key interventions for consideration. In rounds two and three the interventions were ranked on a 9-point Likert scale for effectiveness and feasibility. Round four was an online discussion to establish consensus on effectiveness and feasibility of interventions for which this had not been reached in round three. Twenty-eight interventions were considered both highly effective and feasible in Africa. Interventions covered a range of fields, categorised into direct- or indirect interventions. Direct interventions included: risk assessment and screening; checklists and protocols; monitoring and surveillance; availability of resources; ability to perform technical skills. Indirect interventions included: community and maternal education; contraception and family planning; minimum training standards; referral patterns and delays; advocacy to key stakeholders; simulation and team training; and 24-hour access to safe emergency caesarean delivery. Interventions considered both effective and feasible in reducing peripartum haemorrhage associated with caesarean delivery in Africa were identified. A multi-layered implementation strategy, including immediately developing a perioperative caesarean delivery bundle of care, in addition to longer-term public health measures may have a profound impact on maternal mortality in Africa.
Prevalence and determinants of asymptomatic Leishmania infection in HIV-infected individuals living within visceral leishmaniasis endemic areas of Bihar, India
Authors: Mahajan Raman , Owen Sophie I. , Kumar Shiril , Pandey Krishna , Kazmi Shahwar , Kumar Vikash , Adams Emily R. , Harshana Amit , Burza Sakib
Published: August 2022

People living with HIV (PLHIV) have an increased risk of developing visceral leishmaniasis (VL) and poor outcomes compared to HIV negative individuals. Here, we aim to establish the prevalence and determinants of asymptomatic Leishmania infection (ALI) in a cohort of PLHIV in Bihar, India. We hoped to evaluate optimal diagnostic algorithms to detect ALI in PLHIV. We conducted a cross-sectional survey of PLHIV ≥18 years of age with no history or current diagnosis of VL or post kala-azar dermal leishmaniasis (PKDL) at anti-retroviral therapy centres within VL endemic districts of Bihar. ALI was defined as a positive rK39 enzyme-linked immunosorbent assay (ELISA), rK39 rapid diagnostic test (RDT) and/or quantitative polymerase chain reaction (qPCR). Additionally, the urinary Leishmania antigen ELISA was evaluated. Determinants for ALI were established using logistic regression and agreement between diagnostic tests calculated using Cohen’s Kappa. A total of 1,296 PLHIV enrolled in HIV care, 694 (53.6%) of whom were female and a median age of 39 years (interquartile range 33–46), were included in the analysis. Baseline prevalence of ALI was 7.4% (n = 96). All 96 individuals were positive by rK39 ELISA, while 0.5% (n = 6) and 0.4% (n = 5) were positive by qPCR and rK39 RDT, respectively. Negligible or weak agreement was seen between assays. Independent risk factors for ALI were CD4 counts <100 (OR 3.1; 95% CI 1.2–7.6) and CD4 counts 100–199 (OR = 2.1;95% CI:1.1–4.0) compared to CD4 counts ≥300, and a household size ≥5 (OR = 1.9;95% CI:1.1–3.1). A total of 2.2% (n = 28) participants were positive by Leishmania antigen ELISA, detecting 20 additional participants to the asymptomatic cohort. Prevalence of ALI in PLHIV in VL endemic villages in Bihar was relatively high. Using the Leishmania antigen ELISA, prevalence increased to 9.0%. Patients with low CD4 counts and larger household size were found to have significantly higher risk of ALI.

Trial Registration: Clinical Trial Registration CTRI/2017/03/008120.
The role of the platelet pool of Plasminogen Activator Inhibitor-1 in well-controlled type 2 diabetes patients
Authors: Mossberg Karin , Olausson Josefin , Fryk Emanuel , Jern Sverker , Jansson Per-Anders , Brogren Helén
Published: August 2022

Background

The main inhibitor of the fibrinolytic system, Plasminogen Activator Inhibitor -1 (PAI-1), irreversibly binds tissue-type Plasminogen Activator (t-PA) and thereby inhibits the protective action of tPA against thrombus formation. Elevated levels of plasma PAI-1 are associated with an increased risk of cardiovascular events and are observed in subjects with type 2 diabetes (T2D) and obesity. Platelets contain the majority of PAI-1 present in blood and exhibit the ability to synthesis active PAI-1. Diabetic platelets are known to be hyper-reactive and larger in size; however, whether these features affect their contribution to the elevated levels of plasma PAI-1 in T2D is not established.

Objectives

To characterize the PAI-1 antigen content and the mRNA expression in platelets from T2D subjects compared to obese and lean control subjects, in order to elucidate the role of platelet PAI-1 in T2D.

Methods

Nine subjects with T2D and obesity were recruited from Primary Care Centers together with 15 healthy control subjects (8 lean subjects and 7 with obesity). PAI-1 antigen levels in plasma, serum and platelets were determined by ELISA, and PAI-1 mRNA expression was analyzed by qPCR.

Results

There was no significant difference in PAI-1 mRNA expression or PAI-1 antigen in platelets in T2D subject in comparison to obese and lean control subjects. An elevated level of plasma PAI-1 was seen in both T2D and obese subjects. PAI-1 gene expression was significantly higher in both obese groups compared to lean.

Conclusion

Similar levels of protein and mRNA expression of PAI-1 in platelets from T2D, obese and lean subjects indicate a limited role of platelets for the elevated plasma PAI-1 levels. However, an increased synthesis rate of mRNA transcripts in platelets from T2D and an increased release of PAI-1 could also result in similar mRNA and protein levels. Hence, synthesis and release rates of PAI-1 from platelets in T2D and obesity need to be investigated to further elucidate the role of platelets in obesity and T2D.
Comparative inequalities in child dental caries across four countries: Examination of international birth cohorts and implications for oral health policy
Authors: Goldfeld Sharon , Francis Kate L. , O’Connor Elodie , Ludvigsson Johnny , Faresjö Tomas , Nikiema Beatrice , Gauvin Lise , Yang-Huang Junwen , Abu Awad Yara , McGrath Jennifer J. , Goldhaber-Fiebert Jeremy D. , Faresjo Åshild , Raat Hein , Kragt Lea , Mensah Fiona K. ,   EPOCH Collaborative Group
Published: August 2022

Child dental caries (i.e., cavities) are a major preventable health problem in most high-income countries. The aim of this study was to compare the extent of inequalities in child dental caries across four high-income countries alongside their child oral health policies. Coordinated analyses of data were conducted across four prospective population-based birth cohorts (Australia, n = 4085, born 2004; Québec, Canada, n = 1253, born 1997; Rotterdam, the Netherlands, n = 6690, born 2002; Southeast Sweden, n = 7445, born 1997), which enabled a high degree of harmonization. Risk ratios (adjusted) and slope indexes of inequality were estimated to quantify social gradients in child dental caries according to maternal education and household income. Children in the least advantaged quintile for income were at greater risk of caries, compared to the most advantaged quintile: Australia: AdjRR = 1.18, 95%CI = 1.04–1.34; Québec: AdjRR = 1.69, 95%CI = 1.36–2.10; Rotterdam: AdjRR = 1.67, 95%CI = 1.36–2.04; Southeast Sweden: AdjRR = 1.37, 95%CI = 1.10–1.71). There was a higher risk of caries for children of mothers with the lowest level of education, compared to the highest: Australia: AdjRR = 1.18, 95%CI = 1.01–1.38; Southeast Sweden: AdjRR = 2.31, 95%CI = 1.81–2.96; Rotterdam: AdjRR = 1.98, 95%CI = 1.71–2.30; Québec: AdjRR = 1.16, 95%CI = 0.98–1.37. The extent of inequalities varied in line with jurisdictional policies for provision of child oral health services and preventive public health measures. Clear gradients of social inequalities in child dental caries are evident in high-income countries. Policy related mechanisms may contribute to the differences in the extent of these inequalities. Lesser gradients in settings with combinations of universal dental coverage and/or fluoridation suggest these provisions may ameliorate inequalities through additional benefits for socio-economically disadvantaged groups of children.
Maternal mental health and adverse birth outcomes
Authors: Voit Falk A. C. , Kajantie Eero , Lemola Sakari , Räikkönen Katri , Wolke Dieter , Schnitzlein Daniel D.
Published: August 2022

Recent research in economics emphasizes the role of in utero conditions for the health endowment at birth and in early childhood and for social as well as economic outcomes in later life. This paper analyzes the relation between maternal mental health during pregnancy and birth outcomes of the child. In particular, we analyze the relationship between maternal mental health during pregnancy and the probability of giving birth preterm (PT), having a newborn at low birth weight (LBW) or being small for gestational age (SGA). Based on large population-representative data from the German Socio-Economic Panel (SOEP) and cohort data from the National Educational Panel Study (NEPS), we present extensive descriptive evidence on the relationship between maternal mental health and preterm birth by carrying out OLS estimates controlling for a wide range of socioeconomic characteristics. In addition, we apply matching estimators and mother fixed effects models, which bring us closer toward a causal interpretation of estimates. In summary, the results uniformly provide evidence that poor maternal mental health is a risk factor for preterm birth and low birth weight in offspring. In contrast, we find no evidence for an relationship between maternal mental health and small for gestational age at birth.
High-resolution sediment analysis reveals Middle Bronze Age byre-houses at the site of Oppeano (Verona province, NE Italy)
Authors: Nicosia Cristiano , Polisca Federico , Miller Christopher , Ligouis Bertrand , Mentzer Susan , Mangani Claudia , Gonzato Federica
Published: August 2022

High-resolution sediment analysis allowed us to identify two Middle Bronze Age (MBA 1, 1650–1550 cal a BCE) byre-houses at the waterlogged site of Oppeano “4D”, south of Verona (Veneto region, NE Italy). The site lies in a low-lying valley incised by the Adige River in its LGM alluvial fan. In this fluvio-palustrine environment burial and taphonomic conditions were such that the archaeological record was extremely well preserved. The wooden elements making up basal parts of nine ‘huts’ were in fact exposed at Oppeano, and so were their internal accretion deposits. These featured finely laminated dung units deriving from the stalling of small herbivores, possibly ovicaprids, intercalated with repeated accumulations of wood ash. This was produced in large and multi-stratified hearths that were exposed within each hut. Organic petrology provided evidence of the production of wood tar inside one of the studied structures. At Oppeano 4D it was thus demonstrated that these structures were not just byres or stables, but spaces that housed humans together with animals at least during some periods of the year, hence byre-houses. The identification of byre-houses in a Middle Bronze Age settlement is key for the reconstruction of socio-economic aspects of Bronze Age economy and production systems.
Inter-arm difference in systolic blood pressure: Prevalence and associated factors in an African population
Authors: Gbaguidi Gwladys Nadia , Kaboure Audrey , Houehanou Yessito Corine , Amidou Salimanou Ariyo , Houinato Dismand Stephan , Aboyans Victor , Lacroix Philippe
Published: August 2022

Objectives

Inter-arm blood pressure difference (IABPD) can lead to underdiagnosis and poor management of hypertension, when not recognized and are associated with increased cardiovascular mortality and morbidity. However, the prevalence and associated risk factors of IABPD in sub-Saharan Africa are unknown. This study aims to determine the prevalence and associated risk factors of IABPD among Tanve Health Study (TAHES) participants, a cohort about cardiovascular diseases in a rural area in Benin.

Methods

The cohort was conducted since 2015 among adults aged 25 years and over in Tanve village. Data were collected from February to March, 2020. Brachial blood pressure were recorded at rest on both arm with an electronic device. Systolic IABPD (sIABPD) was defined as the absolute value of the difference in systolic blood pressure between left and right arms ≥ 10 mmHg. A multivariate logistic regression models identified factors associated with sIABPD.

Results

A total of 1,505 participants (women 59%) were included. The mean age was 45.08 ±15.65 years. The prevalence of sIABPD ≥ 10 mmHg was 19% (95%CI: 17–21). It was 19% (95%CI: 16–22) in men and 20% (95%CI: 17–22) in women. In final multivariable model, the probability of sIABPD ≥ 10 mmHg increased significantly with age (adjusted OR (aOR) = 1.1; 95%CI: 1.02–1.20 per 10-years), hypertension (aOR = 2.33; 95%CI: 1.77–3.07) and diabetes (aOR = 1.96; 95%CI: 1.09–3.53).

Conclusion

Almost quarter of sample have a sIABPD ≥ 10 mmHg, with an increased risk with older age and hypertension and diabetes.
Lack of genetic differentiation in yellowfin tuna has conservation implications in the Eastern Pacific Ocean
Authors: Muñoz-Abril Laia , Torres Maria de Lourdes , Valle Carlos A. , Rubianes-Landázuri Francisco , Galván-Magaña Felipe , Canty Steven W. J. , Terán Martin A. , Brandt Margarita , Chaves Jaime A. , Grewe Peter M.
Published: August 2022

Yellowfin tuna, Thunnus albacares, is an important global fishery and of particular importance in the Eastern Pacific Ocean (EPO). According to the 2019 Inter-American Tropical Tuna Commission (IATTC) assessment, yellowfin tuna within the EPO is a single stock, and is being managed as one stock. However, previous studies indicate site fidelity, or limited home ranges, of yellowfin tuna which suggests the potential for multiple yellowfin tuna stocks within the EPO, which was supported by a population genetic study using microsatellites. If numerous stocks are present, management at the wrong spatial scales could cause the loss of minor yellowfin tuna populations in the EPO. In this study we used double digestion RADseq to assess the genetic structure of yellowfin tuna in the EPO. A total of 164 yellowfin tuna from Cabo San Lucas, México, and the Galápagos Islands and Santa Elena, Ecuador, were analysed using 18,011 single nucleotide polymorphisms. Limited genetic differentiation (FST = 0.00058–0.00328) observed among the sampling locations (México, Ecuador, Peru, and within Ecuador) is consistent with presence of a single yellowfin tuna population within the EPO. Our findings are consistent with the IATTC assessment and provide further evidence of the need for transboundary cooperation for the successful management of this important fishery throughout the EPO.
Reductions in US life expectancy during the COVID-19 pandemic by race and ethnicity: Is 2021 a repetition of 2020?
Authors: Andrasfay Theresa , Goldman Noreen
Published: August 2022

COVID-19 had a huge mortality impact in the US in 2020 and accounted for most of the overall reduction in 2020 life expectancy at birth. There were also extensive racial/ethnic disparities in the mortality impact of COVID-19 in 2020, with the Black and Latino populations experiencing reductions in life expectancy at birth over twice as large as that of the White population. Despite continued vulnerability of these populations, the hope was that widespread distribution of effective vaccines would mitigate the overall mortality impact and reduce racial/ethnic disparities in 2021. In this study, we quantify the mortality impact of the COVID-19 pandemic on 2021 US period life expectancy by race and ethnicity and compare these impacts to those estimated for 2020. Our estimates indicate that racial/ethnic disparities have persisted, and that the US population experienced a decline in life expectancy at birth in 2021 of 2.2 years from 2019, 0.6 years more than estimated for 2020. The corresponding reductions estimated for the Black and Latino populations are slightly below twice that for Whites, suggesting smaller disparities than those in 2020. However, all groups experienced additional reductions in life expectancy at birth relative to 2020, and this apparent narrowing of disparities is primarily the result of Whites experiencing proportionately greater increases in mortality in 2021 compared with the corresponding increases in mortality for the Black and Latino populations in 2021. Estimated declines in life expectancy at age 65 increased slightly for Whites between 2020 and 2021 but decreased for both the Black and Latino populations, resulting in the same overall reduction (0.8 years) estimated for 2020 and 2021.
Rainfall-induced hydroplaning risk over road infrastructure of the continental USA
Authors: Salvi Kaustubh Anil , Kumar Mukesh
Published: August 2022

Extreme rainfall causes transient ponding on roads, which increases the risk of vehicle accidents due to hydroplaning (HP), a phenomenon characterized by reduced friction between the pavement surface and the tires of moving vehicles. Before mitigation plans are drawn, it is important to first assess the spatio-temporal patterns of hydroplaning risk (HpR). This study quantifies HpR over the entire continental USA considering the coupled role of precipitation characteristics and pavement properties. Results show the southern United States to be a primary hotspot of HpR. About 22% of road sections experiencing HpR exhibit an increasing trend in the annual occurrence of HP events with time, indicating a riskier future ahead. Alarmingly, road sections that either experience higher HpR or increasing trend in annual occurrences of HP events are the ones with sizeable traffic. These results emphasize the need to prioritize HP-aware road design, traffic management, and signage in regions with high or fast-evolving risks.
Revisiting Late Pleistocene-Early Holocene mountain gazelle (Gazella gazella) body size change in the southern Levant: A case for anthropogenic impact
Authors: Munro Natalie D. , Lebenzon Roxanne , Sapir-Hen Lidar
Published: August 2022

The average body size of human prey animals in archaeological sites is influenced by myriad environmental, physiological and anthropogenic variables. When combined with supporting evidence, body size has the potential to provide a proxy for several variables of fundamental interest to archaeologists including climatic change, food availability and hunting impacts, among other things. In the southern Levant changes in mountain gazelle (Gazella gazella) body size in the Late Pleistocene were initially interpreted as evidence for a climatic downturn, but the picture has become increasingly murky as data has grown. Here we reconsider trends in gazelle body size using an updated dataset from the Mediterranean zone that spans the Early Epipaleolithic to the Middle Pre-Pottery Neolithic B period (ca. 24,000–9,500 cal BP). Our results reveal that gazelle were smallest in the Early and Middle Epipaleolithic (Kebaran and Geometric Kebaran), reached their largest size in the early Late Epipaleolithic (Early Natufian) and then shrunk slightly before stabilizing in size through the Middle Pre-Pottery Neolithic. We see no evidence that sex ratio, or climatic factors influenced this trend. Instead, we explore the role of human impacts on gazelle populations and their habitats as they grew in earnest at the beginning of the Late Epipaleolithic when people first began to settle into more permanent communities. Initially, in the Early and Late Natufian, anthropogenic impacts related to more intensive hunting and the increased footprint of more permanent settlements on the landscape. This may have pushed gazelle numbers below what could be supported by the environment, thus increasing the amount of food available for each animal and hence average body size. Later, as humans began to cultivate plants, manage animals and establish permanent villages, avoidance of humans and livestock by gazelle, and greater stability in food and water availability provided by agriculture, may have similarly reduced gazelle population size and intraspecific competition, thus allowing individual animals to grow larger on average.
Wrack enhancement of post-hurricane vegetation and geomorphological recovery in a coastal dune
Authors: Joyce Matthew A. , Crotty Sinead M. , Angelini Christine , Cordero Orlando , Ortals Collin , de Battisti Davide , Griffin John N.
Published: August 2022

Coastal ecosystems such as sand dunes, mangrove forests, and salt marshes provide natural storm protection for vulnerable shorelines. At the same time, storms erode and redistribute biological materials among coastal systems via wrack. Yet how such cross-ecosystem subsidies affect post-storm recovery is not well understood. Here, we report an experimental investigation into the effect of storm wrack on eco-geomorphological recovery of a coastal embryo dune in north-eastern Florida, USA, following hurricane Irma. We contrasted replicated 100-m2 wrack-removal and unmanipulated (control) plots, measuring vegetation and geomorphological responses over 21 months. Relative to controls, grass cover was reduced 4-fold where diverse storm wrack, including seagrass rhizomes, seaweed, and wood, was removed. Wrack removal was also associated with a reduction in mean elevation, which persisted until the end of the experiment when removal plots had a 14% lower mean elevation than control plots. These results suggest that subsides of wrack re-distributed from other ecosystem types (e.g. seagrasses, macroalgae, uplands): i) enhances the growth of certain dune-building grasses; and ii) boosts the geomorphological recovery of coastal dunes. Our study also indicates that the practice of post-storm beach cleaning to remove wrack–a practice widespread outside of protected areas–may undermine the resilience of coastal dunes and their services.
The meaning of fatherhood to men in relationships with female sex workers in Kampala, Uganda: The struggle to model the traditional parameters of fatherhood and masculinity
Authors: Mbonye Martin , Siu Godfrey , Seeley Janet
Published: August 2022

Many women who engage in sex work in sub-Saharan Africa become pregnant, often unintentionally. There is limited attention paid to the experiences of fathers of children born to women engaged in sex work. We examine the meaning of fatherhood to these men, the significance of children, and how they navigate the economic and cultural challenges of fatherhood in this context. Analysis is based on ethnographic data from 13 men who identified as intimate long-term partners of female sex workers (FSW) in Kampala City, Uganda. Our findings illustrate how men who have children with FSW struggled to model the traditional parameters of fatherhood and masculinity. We found that men who had children with FSW faced hurdles fitting within the social construction of ideal fatherhood. Accepting fatherhood often started with doubts over the pregnancy because of the multiple partnerships of women. Men who only saw themselves as clients struggled to adjust to being fathers because of their perceptions of the social implications of fathering a child with a FSW. Integration of mothers who were also sex workers into the man’s extended family was a challenge because of the fear of negative reactions from family members. However, when men accepted their roles as fathers, they started seeing value in their children. Due to poverty, most of the men fell short of the societal measures of masculinity, but children transformed their social status before their society and family. The provider role often used to define good fathering was a challenge for men. However, the financial support from FSW partners softened the burden and facilitated the creation of a family environment constructed to the perceived standards of the broader society. Our findings provide insights into the state of parenting among FSW and their partners which can guide interventions that are tailored to their unique circumstances.
Perceptual cognitive abilities in young athletes: A gender comparison
Authors: Legault Isabelle , Sutterlin-Guindon Dylan , Faubert Jocelyn
Published: August 2022

To achieve optimal performance in sports, it is essential to have strong perceptual cognitive abilities. Evidence suggests that athletes have superior perceptual abilities compared to nonathletes. However, gender differences in athletes’ perceptual cognitive abilities have not been previously reported. This project aims to evaluate perceptual cognitive abilities among male and female adolescents. To measure perceptual abilities, a 3-dimensional multiple-object tracking task was used. The findings confirm the superior perceptual cognitive abilities in young athletes relative to nonathletes. However, our results indicate differences in performance patterns between male and female athletes. These results demonstrate that sports engagement and perceptual cognitive abilities are strongly related during adolescence and that this relationship seems more prevalent in male athletes for this age group.
Siamese network with a depthwise over-parameterized convolutional layer for visual tracking
Authors: Wang Yuanyun , Zhang Wenshuang , Zhang Limin , Wang Jun
Published: August 2022

Visual tracking is a fundamental research task in vision computer. It has broad application prospects, such as military defense and civil security. Visual tracking encounters many challenges in practical application, such as occlusion, fast motion and background clutter. Siamese based trackers achieve superior tracking performance in balanced accuracy and tracking speed. The deep feature extraction with Convolutional Neural Network (CNN) is an essential component in Siamese tracking framework. Although existing trackers take full advantage of deep feature information, the spatial structure and semantic information are not adequately exploited, which are helpful for enhancing target representations. The lack of these spatial and semantic information may lead to tracking drift. In this paper, we design a CNN feature extraction subnetwork based on a Depthwise Over-parameterized Convolutional layer (DO-Conv). A joint convolution method is introduced, namely the conventional and depthwise convolution. The depthwise convolution kernel explores independent channel information, which effectively extracts shallow spatial information and deep semantic information, and discards background information. Based on DO-Conv, we propose a novel tracking algorithm in Siamese framework (named DOSiam). Extensive experiments conducted on five benchmarks including OTB2015, VOT2016, VOT2018, GOT-10k and VOT2019-RGBT(TIR) show that the proposed DOSiam achieves leading tracking performance with real-time tracking speed at 60 FPS against state-of-the-art trackers.
Neutralizing-antibody response to SARS-CoV-2 for 12 months after the COVID-19 workplace outbreaks in Japan
Authors: Ishizaki Azumi , Bi Xiuqiong , Nguyen Quynh Thi , Maeno Tomomi , Hara Akinori , Nakamura Hiroyuki , Kuramoto Sanae , Nishi Koichi , Ooe Hiroyasu , Ichimura Hiroshi
Published: August 2022

This study aimed to elucidate the 12-month durability of neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients infected during the 2020 workplace outbreaks of coronavirus disease 2019 (COVID-19) in Japan. We followed 33 Japanese patients infected with SARS-CoV-2 in April 2020 for 12 months (12M). Patients were tested for NAbs and for antibodies against the SARS-CoV-2 nucleocapsid (anti-NC-Ab) and antibodies against the spike receptor-binding domain (anti-RBD-Ab). Tests were performed at 2M, 6M, and 12M after the primary infection (api) with commercially available test kits. In 90.9% (30/33) of patients, NAbs persisted for 12M api, though the median titers significantly declined from 78.7% (interquartile range [IQR]: 73.0–85.0%) at 2M, to 59.8% (IQR: 51.2–77.9) at 6M (P = 0.008), and to 56.2% (IQR: 39.6–74.4) at 12M (P<0.001). An exponential decay model showed that the NAb level reached undetectable concentrations at 35.5 months api (95% confidence interval: 26.5–48.0 months). Additionally, NAb titers were significantly related to anti-RBD-Ab titers (rho = 0.736, P<0.001), but not to anti-NC-Ab titers. In most patients convalescing from COVID-19, NAbs persisted for 12M api. This result suggested that patients need a booster vaccination within one year api, even though NAbs could be detected for over two years api. Anti-RBD-Ab titers could be used as a surrogate marker for predicting residual NAb levels.
Stroke volume and cardiac output during 6 minute-walk tests are strong predictors of maximal oxygen uptake in people after stroke
Authors: Liu Fang , Jones Alice Y. M. , Tsang Raymond C. C. , Zha Fubing , Zhou Mingchao , Xue Kaiwen , Zhang Zeyu , Wang Yulong
Published: August 2022

Background and objectives

The 6-minute walk test (6MWT) is a field test commonly used to predict peak oxygen consumption (VO2peak) in people after stroke. Inclusion of cardiodynamic variables measured by impedance cardiography (ICG) during a 6MWT has been shown to improve prediction of VO2peak in healthy adults but these data have not been considered in people after stroke. This study investigates whether the prediction of VO2peak can be improved by the inclusion of cardiovascular indices derived by impedance cardiography (ICG) during the 6MWT in people after stroke.

Methods

This was a cross-sectional study. Patients diagnosed with stroke underwent in random order, a maximal cardiopulmonary exercise test (CPET) and 6MWT in separate dates. Heart rate (HR), stroke volume (SV) and cardiac output (CO) were measured by ICG during all tests. Oxygen consumption was recorded by a metabolic cart during the CPET. Recorded data were subjected to multiple regression analyses to generate VO2peak prediction equations.

Results

Fifty-nine patients, mean age 50.0±11.7 years were included in the analysis. The mean distance covered in the 6MWT (6MWD) was 294±13 m, VO2peak was 19.2±3.2 ml/min/kg. Mean peak HR, SV and CO recorded during 6MWT were 109±6 bpm, 86.3±8.8 ml, 9.4±1.2 L/min and during CPET were 135±14 bpm, 86.6±9 ml, 11.7±2 L/min respectively. The prediction equation with inclusion of cardiodynamic variables: 16.855 + (-0.060 x age) + (0.196 x BMI) + (0.01 x 6MWD) + (-0.416 x SV6MWT) + (3.587 x CO 6MWT) has a higher squared multiple correlation (R2) and a lower standard error of estimate (SEE) and SEE% compared to the equation using 6MWD as the only predictor.

Conclusion

Inclusion of SV and CO measured during the 6MWT in stroke patients further improved the VO2peak prediction power compared to using 6MWD as a lone predictor.
Functionally impaired isoforms regulate TMPRSS6 proteolytic activity
Authors: Dion Sébastien P. , Désilets Antoine , Lemieux Gabriel , Leduc Richard
Published: August 2022

TMPRSS6 is a type II transmembrane serine protease involved in iron homeostasis expressed as 4 isoforms in humans. TMPRSS6 isoform 2 downregulates hepcidin production by cleaving hemojuvelin and other surface proteins of hepatocytes. The functions of catalytically impaired isoforms 3 and 4 are still unknown. Here we demonstrate that TMPRSS6 isoforms 3 and 4 reduce the proteolytic activity of isoform 2 and uncover the ability of isoforms to interact. Moreover, we identified 49 potential protein partners common to TMPRSS6 isoforms, including TfR1, known to be involved in iron regulation. By co-expressing TMPRSS6 and TfR1, we show that TfR1 is cleaved and shed from the cell surface. Further, we demonstrate that TMPRSS6 isoforms 3 and 4 behave as dominant negative.
From crop specific to variety specific in crop modeling for the smart farm: A case study with blueberry
Authors: Han Gyung Deok , Choi Jeong Min , Choi Inchan , Kim Yoonha , Heo Seong , Chung Yong Suk
Published: August 2022

Facility cultivation has been evolved from greenhouses to smart farms using artificial intelligence (AI) that simulates big data to maximize production. However, the big data for AI in smart farm is not studied well; the effect of differences among varieties within a crop remains unclear. Therefore, the response of two varieties of blueberry, ‘Suziblue’ and ‘Star’, to light was tested using SAPD meter in order to demonstrate the environmental responses could be different among varieties within the same species. The results showed that those two varieties had significant differences in SPAD values based on the leaf’s position and time, whereas ‘Star’ did not. This indicates that the effect of light depends on the variety, which implies that other traits and other crops may show similar differences. These results are based on a simple experiment. However, it is enough to elucidate that it is extremely important to characterize responses to the environment not only for each crop but also for each variety to collect data for smart farming to increase accuracy for modeling; consequently, to maximize the efficiency of these facilities.
Integrating herbivore assemblages and woody plant cover in an African savanna to reveal how herbivores respond to ecosystem management
Authors: Schmitt Melissa H. , Stears Keenan , Donovan Mary K. , Burkepile Deron E. , Thompson Dave I.
Published: August 2022

African savannas are experiencing anthropogenically-induced stressors that are accelerating the increase of woody vegetation cover. To combat this, land managers frequently implement large-scale clearing of trees, which can have a cascading influence on mammalian herbivores. Studies rarely focus on how differences in woody cover influence the herbivore assemblage, making it difficult to assess how aggressive measures, or the lack of management, to counteract increasing woody cover affect the local composition and biodiversity of herbivores. We address this knowledge gap by applying a model-based clustering approach to field observations from MalaMala Game Reserve, South Africa to identify multiple herbivore–vegetation ‘configurations,’ defined as unique sets of herbivore assemblages (i.e., groups of herbivores) associated with differing woody plant covers. Our approach delineated how tree-clearing influences the distribution and abundance of the herbivore community in relation to surrounding savanna areas, which represent a natural mosaic of varying woody cover. Regardless of season, both intensively managed areas cleared of trees and unmanaged areas with high tree cover contained configurations that had depauperate assemblages of herbivores (low species richness, low abundance). By contrast, habitats with intermediate cover of woody vegetation had much higher richness and abundance. These results have substantial implications for managing African savannas in a rapidly changing climate.
HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy
Authors: Guo Shuang , Luke Brian T. , Henry Amy R. , Darko Samuel , Brandt Leah D. , Su Ling , Sun David , Wells Daria , Joseph Kevin W. , Demirov Dimiter , Halvas Elias K. , Douek Daniel C. , Wu Xiaolin , Mellors John W. , Hughes Stephen H.
Published: August 2022

Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for understanding the stability of the reservoir; however, the stabilities of clones of infected T cells in persons on long-term ART are not well defined. We determined the relative stabilities of clones of infected and uninfected CD4+ T cells over time intervals of one to four years in three individuals who had been on ART for 9–19 years. The largest clones of uninfected T cells were larger than the largest clones of infected T cells. Clones of infected CD4+ T cells were more stable than clones of uninfected CD4+ T cells of a similar size. Individual clones of CD4+ T cells carrying intact, infectious proviruses can expand, contract, or remain stable over time.
Understanding gendered trait preferences: Implications for client-responsive breeding programs
Authors: McDougall Cynthia , Kariuki Juliet , Lenjiso Birhanu M. , Marimo Pricilla , Mehar Mamta , Murphy Seamus , Teeken Béla , Akester Michael J. , Benzie John A. H. , Galiè Alessandra , Kulakow Peter , Mekkawy Wagdy , Nkengla-Asi Lilian , Ojango Julie M. K. , Tumuhimbise Robooni , Uwimana Brigitte , Orr Alastair
Published: August 2022

Client-responsiveness is a foundation for effectiveness of public sector breeding programs in agriculture, aquaculture and livestock. However, there remains a considerable lack of clarity about what this means, specifically in terms of how programs can be gender-responsive. This study contributes to addressing that need. It does so through sharing higher-level insights emerging from the combined experiences of eight gendered trait preference cases from across nine countries in Asia and Africa. The cases spanned crops, fish and livestock. This study inquires into the nature of gendered trait preference information that can be generated, if there are systematic gendered preference differences and how to understand these, and implications for breeding programs seeking to be more gender-responsive. Key findings include that while not all data are immediately usable by programs, the information that is generated through mixed method, intersectional gender preference assessments usefully deepens and widens programs’ knowledge. The study evidences differences in trait preferences between women and men. It also reveals that these differences are more complex than previously thought. In doing so, it challenges binary or homogenous models of preferences, suggesting instead that preferences are likely to be overlapping and nuanced. The study applies a novel ‘Three models of gendered trait preferences’ framework and sub-framework and finds these useful in that they challenge misconceptions and enable a needed analytical nuance to inform gender-responsive breeding programs. Finally, the study highlights implications and offers a call to action for gender-responsive breeding, proposing ways forward for public breeding programs, teams and funding agencies. These include investments in interdisciplinary capabilities and considerations for navigating trade-offs while orienting to sustainable development goals.
Movimientos exocanónicos de la literatura contemporánea
Authors: Gómez Trueba Teresa
Published: August 2022

El libro Movimientos exocanónicos de la literatura contemporánea aborda el contexto de deslegitimación de las reglas de formación del canon en el siglo XXI a raíz del empleo de nuevos mecanismos y soportes de creación y de la atención a inéditas cuestiones éticas que atañen a las sociedades actuales, intereses que comparten los proyec­tos de investigación «Exocanónicos: márgenes y descentramiento en la literatura en español del siglo XXI» (PID2019-104957GA-I00) y «Fractales: estrategias para la fragmentación en la narrativa española del siglo XXI» (PID2019-104215GB-I00), financiados por MCIN/ AEI /10.13039/501100011033. A partir de géneros y conceptos como el neofolclore, el fanfiction, el microrrelato, el tráiler, el rap, el rock, el sampler, las estéticas digitales, los sujetos artificiales, la realidad distópica, las genealogías feministas o la autoficción escrita por mujeres, los doce trabajos que conforman este volumen se in­terrogan acerca de una cuestión fundamental: ¿de qué manera las obras y espacios de producción, difusión y recepción exocanónicos perturban nuestras certezas sobre el canon?
Prognostic factors associated with survival and hospitalization time in pediatric canine patients diagnosed with presumptive acute viral gastroenteritis
Authors: Magalhães Tomás Rodrigues , Gregório Hugo , Araújo João , Ribeiro Lénio , Dourado Maria João , Batista Sofia , Queiroga Felisbina Luisa
Published: August 2022

Background and Aim: Acute viral gastroenteritis is one of the main causes of hospitalization in dogs during the 1st year of life. This retrospective study aimed to describe a pediatric canine population presumptively diagnosed with acute viral gastroenteritis and to identify potential prognostic factors that influence hospitalization time (HT) and mortality.

Materials and Methods: Canine patients up to 12 months of age diagnosed with presumptive acute viral gastroenteritis were searched retrospectively from two veterinary hospitals during a 5-year period (2015–2020). Information regarding patient signalment, prophylactic care, clinical signs, blood test results, presence of systemic inflammatory response syndrome, and additional treatments were recorded to analyze their association with HT and mortality. Only dogs with a complete medical record until death or discharge were included in the study.

Results: Ninety-four dogs were identified: 76 dogs (80.9%) survived with a median HT of 5 days (range: 2–16 days) and 18 dogs (19.1%) died with a median HT of 3½ days (range: 1–8 days) after admission. The presence of fever and fresh frozen plasma (FFP) administration was significantly associated with a lower survival rate (p = 0.021 and p = 0.037) in the multivariate analysis. Among survivors, incomplete primo-vaccination, the presence of hematochezia, and FFP administration were considered independent predictors of time to clinical recovery (p = 0.026, p = 0.047, and p = 0.026, respectively), being associated with higher HT.

Conclusion: The presence of fever and FFP administration was significantly associated with a lower survival rate. An inadequate primo-vaccination status prior to admission, hematochezia, and FFP administration was associated with longer HT in surviving patients. Further studies are needed to confirm the present results.
Exact solution of the Susceptible–Infectious–Recovered–Deceased (SIRD) epidemic model
Authors: Yoshida Norio
Published: August 2022

Exact solution of the Susceptible-Infectious-Recovered-Deceased (SIRD) epidemic model is established, and various properties of solution are derived directly from the exact solution. The exact solution of an initial value problem for SIRD epidemic model is represented in an explicit form, and it is shown that the parametric form of the exact solution is a solution of some linear differential system.