bluuebunny/crossref_metadata_2025 huggingface dataset:
Romantic relations, sexuality and intimacy among young adults and adolescents with severe mental illness, intellectual disability and Down syndrome: a review of the literature
Authors: Belluzzo Miriam , Esposito Camilla , De Alfieri Erica , Giaquinto Veronica , Volpe Daniela , Amodeo Anna Lisa
Published: April 2024

Background
Although sexual health and well-being have gained recognition as vital parts of a person’s overall well-being despite possible conditions of disability, individuals with severe mental illness, as well as people with intellectual disability and Down syndrome, especially adolescents and young adults, often face stigma and human rights violations which, in association with the specific nature of their clinical condition, impacting their self-esteem and the ability to form meaningful relationships and express their own sexuality.
Methods
Prioritizing the perspective of young people themselves with diagnoses of severe mental illness (schizophrenic spectrum disorders and psychosis), intellectual disability and Down syndrome, electronic databases were consulted and articles published in English concerning sexuality, intimacy and romantic relations were included. The only exception is a study in Spanish included due to its consistent relevance with the aim of the review. The reference sections of the relevant articles were reviewed for additional pertinent publications.
Results
A total of 32 studies were included and analyzed, showing that sexual and reproductive health of individuals with severe mental illness, intellectual disability and Down syndrome, particularly adolescents and young adults, is notably poorer compared to the general population. In the case of severe mental illness and mild intellectual disability, this disparity leads to increased vulnerability, including gender-based violence, risky sexual behavior, and exploitation, compounded by self-stigmatization, social isolation, and cognitive deficits inherent these disorders, impacting emotional and sexual well-being. Similarly, individuals with severe intellectual disability, including Down syndrome, exhibit greater interest in social interactions struggling to understand social boundaries facing risks of exploitation and victimization, due to the lack of appropriate sex education.
Conclusions
Despite the contemporary advancements in treatment modalities and increased understanding, individuals with severe mental illness, intellectual disabilities and Down syndrome, face significant challenges in their sexual lives. Societal misconceptions perpetuate the denial of appropriate sex education and reproductive choices, leaving those individuals vulnerable to victimization. Addressing these needs through comprehensive education and support is crucial to mitigate risks and improve overall well-being.
Loss-of-function mutation in the polyamine transporter gene OsLAT5 as a potential selectable marker for genome editing
Authors: Schenstnyi Kyrylo , Zhang Zhengzhi , Liu Bo , Nakamura Masayoshi , Schepler-Luu Van , Loo Eliza P.I. , Yang Bing , Frommer Wolf B.
Published: April 2024

Genome editing by TALENs and CRISPR/Cas has become routine tools. During stable plant transformation, genes coding for editing enzymes, e.g., Cas9, guide RNAs (gRNA), and selectable markers are integrated into the nuclear genome. Identification of successful transformants relies on selectable or screenable markers, typically genes providing resistance to herbicides or antibiotics. Selectable markers use a substantial portion of the T-DNA, hence reducing transfer efficiency by limiting the effective number of TALENs or guide/pegRNAs that can be used. Marker genes are frequently subject to gene silencing. Here, we generated loss-of-function mutations in PUT/LAT-type polyamine transporter family genes to confer resistance to methylviologen (MV). As proof of concept, CRISPR/Cas9 constructs with gRNAs were constructed to target three close homologs OsLAT1, OsLAT5, and OsLAT7. Loss of OsLAT5(also known as OsPUT3 or OsPAR1) function was sufficient to confer resistance to MV in rice seeds, seedlings and calli, validating the editing approach of OsLAT5 to obtain a selectable marker. We discuss use of a gRNA cassette (OsLAT5) as selectable marker and reporter for successful genome editing for optimizing editing protocols.
Light sensitivity in PANi/TiO2 double nanolayer
Authors: Huyen Duong Ngoc , Tuan Mai Van , Dung Mai Xuan
Published: April 2024

A double layer of polyaniline (PANi) and titanium dioxide (TiO2) made on glass substrate is used to study the effect of photoinduction in TiO2 on the double layer conductance. The light sources are LEDs emitting monochromatic light peaking around 369, 396, 447 and 663 nm. Raman and UV-Vis spectra show that the electronic structure of PANi in the double layer is modified as a result of the TiO2 coupling. The conductance of the PANi and PANi/TiO2 double layer is found to be sensitive to the light irradiated and depends on the light wavelength. Upon exposure to the light, the conductance of the PANi monolayer is increased while the PANi/TiO2 double layer is decreased with 369, 396 and 447 nm but increased with 663 nm monochromatic light. The change in conductance of the PANi and PANi/TiO2 double layer is accounted for the combination of the carriers arisen from photoelectric effect in PANi and the carrier added/extracted from PANi as a result of photoinduced effect in TiO2 as the layer activated by light.
Extracts from Capsicum annuum as Natural sensitizer in Dye Sensitized Solar Cell : Theoretical analysis using DFT and TD-DFT
Authors: Espinoza-Curilen Oscar Matias , Thompson Sade White , Manidurai Paulraj , Paredes-Gil Katherine
Published: April 2024

Sensitizers derived from Capsicum annum were studied using computational methods (DFT and TD-DFT) for their potential application in DSSC. The UV-Vis computed spectra describe a band around 450 nm that involves a π-π* electronic transition associated with the frontier orbitals HOMO -LUMO localized in the large chain of double bonds of the capsorubin and capsanthin. This very much coincides with the experimental values and shows a potential activity for the photoexcitation. Moreover, the behaviour towards the adsorption and electron injection of the Capsicum annuum to TiO2 semiconductor was analyzed through periodic calculations of the capsorubin@(TiO2)72, capsanthin@(TiO2)72 and capsaicin@(TiO2)72 models. The first two show an opposite result for the capsaicin sensitizer. Specifically, hydrogen bonds were found between the methyl substituents of the carotenoids and the oxygen on the TiO2 surface, suggesting an O-H electrostatic interaction. Capsaicin was found to lose linearity around the amide group (C-NH-CO 180°), transforming into an angular rearrangement (C-NH-CO 120°). These structural changes influence the electronic injection of Capsicum annuum into the TiO2 semiconductor. Thus, the low efficiency reported in carotenoid is due to the presence of weak interactions.
Autoimmune markers have a certain value to assess thyroid function in type 1 diabetes children
Authors: Song Wei
Published: April 2024

Background
Examine risk factors for thyroid dysfunction in children with type 1 diabetes mellitus (T1DM).
Methods
Altogether, 73 Chinese children were examined at the onset of T1DM and after 12 months. Thyroid hormone levels and other biochemical data were measured. Data were compared based on thyroid status.
Results
C-peptide, hemoglobin A1c (HbA1c), free triiodothyronine, and free (unbound) thyroxine levels did not change during the study period. Antibodies to glutamic acid decarboxylase were found in 31.8%, autoantibodies to insulin in 22.7%, islet cell antibodies in 0%, thyroid peroxidase antibodies in 35.3%, and anti-thyrotropin receptor antibodies in 5.9% of subjects. Mean concentrations of anti-thyrotropin receptor antibody and thyroid peroxidase antibody were significantly higher in hyperthyroid children than euthyroid children. However, free thyroxine, thyroid-stimulating hormone, anti-thyrotropin receptor antibody, and anti-thyroid peroxidase antibody concentrations were similar between hypothyroid and euthyroid children.
Conclusions
Positive thyroid peroxidase antibody is higher in children with T1DM than normal children. The presence of thyroid peroxidase antibody and glutamic acid decarboxylase antibodies may lead to poorly controlled diabetes. Finally, T1DM children with thyroid peroxidase antibody were less likely to develop hypothyroidism after onset of diabetes within a one-year follow-up.
A SGM-IHB approach for nonlinear free and forced vibration analysis of FG-GPLRC beams rested on viscoelastic foundation
Authors: Wang Ruihua , Zhong Rui , Wang Qingshan
Published: April 2024

Combining the spectral geometry method and the incremental harmonic balance method (IHB), the nonlinear analytical model of functionally graded graphene platelet reinforced composite (FG-GPLRC) beams is developed in this paper. Nonlinear free and forced vibration characteristics are studied based on this model containing viscoelastic foundation and geometric nonlinear factors. Geometric nonlinear strain-displacement relationship and Lagrangian energy generalization for the FG-GPLRC beam structure are derived according to the Von-Kármán and Timoshenko theories. The IHB method is applied to track the nonlinear vibration response solution of the reduced-order model, which is constructed by introducing linear modal components into the overall nonlinear dynamic equation of the FG-GPLRC beam. Through comparison of the present solution with those from numerical method and literature, the correctness of the established nonlinear analytical model is evidenced. Further, the influence of material-, geometry-, foundation-related parameters and boundary constraints on the nonlinear frequency parameter and amplitude-frequency response of FG-GPLRC beams rested on viscoelastic foundation is analyzed, which can serve as a theoretical guide for designing and evaluating the dynamic environment adaptation of FG-GPLRC beams.
Major cardiovascular events in long-term multiple myeloma survivors: A Korean case- control study (The CAREMM-2105 study)
Authors: Ha Jeonghoon , Choi Suein , Moon Seulji , Han Jinseon , Lee Jeongyoon , Baek Ki-Hyun , Han Seunghoon , Park Sung-Soo , Min Chang-Ki
Published: April 2024

Purpose: Despite improvements in multiple myeloma (MM) survival rates, data on cardiovascular outcomes in long-term survivors remain lacking.Methods: This retrospective case-control study utilized the Korean National Health Insurance Service database (2009–2020) to compare the incidence of cardiovascular disease (CVD) between patients with MM and a matched control group, focusing on long-term (>5 years) survivors. A preliminary case cohort (n=15,402 patients with MM) and a matched control cohort (n=123,216 patients without MM) were established based on birth year and sex. Following 1:1 propensity score matching, the final matched cohorts each comprised 15,402 participants.Results: The case and control cohorts were comparable in mean age (66.2±11.5 years vs. 66.1±11.3 years), sex, age distribution, and comorbidities. By the 8-year follow-up, the cumulative incidence of CV events (12.5% vs. 22.1%) and CVD risk were significantly lower in the case cohort. The 5-year landmark analysis revealed significant differences in CVD incidence between the cohorts (7.8% [case cohort] vs. 9.8% [control cohort]), with variations across age groups and sex, highlighting a significantly higher CVD risk among patients aged <50 years in the case cohort (P<0.001).Conclusions:These findings underscore the need for vigilant CVD monitoring in MM long-term survivors, particularly those aged <50 years at first diagnosis.Implication for Cancer Survivors: This study highlights the importance of integrating cardiovascular monitoring and risk management into long-term care for MM survivors, with a focus on younger patients and personalized interventions.
Prominent ethylene glycol sensing of sol-gel derived ZnO and ZnO:Cu nano-structures
Authors: Karouei Seyedeh Faezeh Hashemi , Shaddoust Mahdi , Khatibani Abbas Bagheri , Rezapour Arefeh , Ahmadi Mohammad Hadi
Published: April 2024

Within this work, pristine zinc oxide and copper-doped powders were prepared using a sol–gel technic. Important physical properties such as morphological, optical, and structural features of the samples have been studied. Different data including X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), and Brunauer–Emmett–Teller analysis (BET), UV–Vis spectrophotometry, and Fourier transform infrared spectroscopy (FTIR) were collected to investigate the physical features of the samples. In addition, the ethylene glycol vapor sensing capability of the prepared samples was investigated and compared with other vapors like as ethanol, methanol, acetone, isopropanol, and dimethylformamide. The results demonstrated that the samples have a very good selectivity to ethylene glycol (up to 50 times for ZnO and 13 times for ZnO:Cu 20%). The most important parameter of sensing namely operating temperature, real-time variation, sensitivity, and response/recovery times were also evaluated for pristine zinc oxide and copper-doped nano-structures. Specifically, the ZnO nano-structure sensor represented prominent sensitivity of about 37 and 139 towards for ethylene glycol concentration of 200 and 700 ppm, respectively.
Effect of temperature on the mixed mode I/II translaminar fracture of laminated composites reinforced with natural fibers
Authors: Zeinedini Afshin , Hassan Yosra Basim
Published: April 2024

In recent years, laminated composites reinforced with natural fibers have extensively used in the various industries. One of the most important failure modes of laminated composite materials is translaminar fracture under different loading conditions. In this research, the effect of temperature on the translaminar critical strain energy release rate (CSERR) of the composites reinforced with cotton fibers was investigated. The cotton/epoxy samples were placed at different temperature conditions of 30, 0, and − 30°C. The translaminar CSERR values of cotton/epoxy laminated composites were obtained under pure mode I, mixed mode I/II with two different loading angles, and pure mode II loading conditions. To calculate the translaminar CSERR based on experimental results, numerical modeling was also performed. Besides, a modified version of Mixed Mode Fracture Envelope criterion was proposed to predict the mixed mode I/II translaminar fracture behavior of the cotton/epoxy laminated composites at the mentioned temperatures. The results showed that lowering the temperature has a great impact on the translaminar CSERR. It was also concluded that the change in the temperature had the greatest effect on the value of the mode I translaminar CSERR. Moreover, as the temperature decreased from 30 to 0 and − 30°C, the value of the mode I translaminar CSERR decreased around 80 and 90%, respectively.
Overexpression of dehydroascorbate reductase gene IbDHAR1 improves the tolerance to abiotic stress in sweet potato
Authors: Cheng Qirui , Zou Xuan , Wang Yuan , Yang Zhe , Qiu Xiangpo , Wang Sijie , Yang Yanxin , Yang Dongjing , Kim Ho Soo , Jia Xiaoyun , Li Lingzhi , Kwak Sang-Soo , Wang Wenbin
Published: April 2024

Dehydroascorbate reductase (DHAR), an indispensable enzyme in the production of ascorbic acid (AsA) in plants, is vital for plant tolerance to various stresses. However, there is limited research on the stress tolerance functions of DHAR genes in sweet potato (Ipomoea batatas [L.] Lam). In this study, the full-length IbDHAR1 gene was cloned from the leaves of sweet potato cultivar Xu 18. The IbDHAR1 protein is speculated to locate in both the cytoplasm and the nucleus. As revealed by qRT-PCR, the relative expression level of IbDHAR1 in the proximal storage roots was much greater than in the other tissues, and could be upregulated by high-temperature, salinity, drought, and abscisic acid (ABA) stress. The results of pot experiments indicated that under high salinity and drought stress conditions, transgenic Arabidopsis and sweet potato plants exhibited decreases in H2O2 and MDA levels. Conversely, the levels of antioxidant enzymes APX, SOD, POD, and ACT, and the content of DHAR increased. Additionally, the ratio of AsA/DHA was greater in transgenic lines than in the wild type. The results showed that overexpression of IbDHAR1 intensified the ascorbic acid-glutathione cycle (AsA-GSH) and promoted the activity of the related antioxidant enzyme systems to improve plant stress tolerance and productivity.
Ablation of the integrin CD11b mac-1 limits deleterious responses to traumatic spinal cord injury and improves functional recovery in mice
Authors: Li Yun , Ritzel Rodney M. , He Junyun , Liu Simon , Zhang Li , Wu Junfang
Published: April 2024

Background: Spinal cord injury (SCI) causes long-term sensorimotor deficits and posttraumatic neuropathic pain, with no effective treatment. In part, this reflects an incomplete understanding of the complex secondary pathobiological mechanisms involved. SCI triggers microglial/ macrophage activation with distinct pro-inflammatory or inflammation-resolving phenotypes, which potentiate tissue damage or facilitate functional repair, respectively. The major integrin Mac-1 (CD11b/CD18, αMβ2 or CR3), a heterodimer consisting of αM (CD11b) and β2 (CD18) chains, is generally regarded as a pro-inflammatory receptor in neurotrauma. Multiple immune cells of the myeloid lineage express CD11b, including microglia, macrophages, and neutrophils. In the present study, we examined the effects of CD11b gene ablation on posttraumatic neuroinflammation and functional outcomes after SCI.
Methods: Young adult age-matched female CD11b knockout (KO) mice and their wildtype (WT) littermates were subjected to moderate thoracic spinal cord contusion. Neuroinflammation in the injured spinal cord was assessed with qPCR, flow cytometry, NanoString, and RNAseq. Neurological function was evaluated with the Basso Mouse Scale (BMS), gait analysis, thermal hyperesthesia, and mechanical allodynia. Lesion volume was evaluated by GFAP-DAB immunohistochemistry, followed by analysis with unbiased stereology.
Results: qPCR analysis showed a rapid and persistent upregulation of CD11b mRNA starting from 1d after injury, which persisted up to 28 days. At 1d post-injury, increased expression levels of genes that regulate inflammation-resolving processes were observed in CD11b KO mice. Flow cytometry analysis of CD45intLy6C-CX3CR1+ microglia, CD45hiLy6C+Ly6G- monocytes, and CD45hiLy6C+Ly6G+ neutrophils revealed significantly reduced cell counts as well as reactive oxygen production in CD11b KO mice at d3 post-injury. Further examination of the injured spinal cord with NanoString Mouse Neuroinflammation Panel and RNAseq showed upregulated expression of pro-inflammatory genes, but downregulated expression of the reactive oxygen species pathway. Importantly, CD11b KO mice exhibited significantly improved locomotor function, reduced cutaneous mechanical/thermal hypersensitivity, and limited tissue damage at 8 weeks post-injury.
Conclusion: Collectively, our data suggest an important role for CD11b in regulating tissue inflammation and functional outcome following SCI. Thus, the integrin CD11b represents a potential target that may lead to novel therapeutic strategies for SCI.
Mathematical Modelling of COVID-19 Pandemic Putting into consideration Pathogens in the Environment
Authors: Chamber Nuraddeen suleiman mohd , Hasssan shitu
Published: April 2024

We develop a compartmental epidemic mo del which takes into consideration hospitalized individuals and pathogens in the environment that describes a more realistic mathematical model for understanding the trans mission dynamics and control of COVID-19 in Nigeria. The next generation matrix approach is used to determine the control reproduction number (R0C) which we found to be 2.76 implying that the pandemic will persist in the absence of strong control measures. Rigorous mathematical analysis is used to study several properties of the model. We also studied the sensitivity analysis of the model parameters to know the parameters that have a high impact on the reproduction number (R0C). The model was parameterized using COVID-19 data published by Nigeria Center for Disease Control (NCDC). The numerical simulation also carried out to verify the theoretical results. The model shows that the hospitalized individuals and pathogens in the environment have positive impact on the control reproduction number (R0C).
Effects of sexual counseling and education based on self-efficacy theory on the sexual function of women with breast cancer
Authors: Jamshidi Azadeh , Gharibi Taiebeh , Noroozi Farzaneh , Bagherzadeh Razieh
Published: April 2024

Background: The diagnosis and treatment of breast cancer are associated with side effects that can affect patients' self-efficacy and various aspects of their quality of life, including their sexual function. Therefore, this study was conducted with the aim of investigating the effect of sexual counseling and education based on self-efficacy theory on the sexual function of women with breast cancer.
Method: This randomized controlled trial used a pretest, posttest, control group, and one-month follow-up design. It included 45 female breast cancer survivors, recruited from the clinics and hematology wards of Bushehr, Iran. The inclusion criterion was that at least three months should have passed since the last chemotherapy/radiotherapy. The participants were randomly assigned to two experimental and control groups. The experimental group received two training sessions and three counseling sessions based on efficacy theory. A demographic information form and a female sexual function index questionnaire were used for data collection, and the participants completed the questionnaire in the pretest, posttest, and follow-up stages. Chi-square, Mann–Whitney U, repeated-measures ANOVA, and Fisher's Least Significant Difference (LSD) test were used to analyze the data. P<0.05 was considered statistically significant.
Result: At the posttest stage, statistically significant improvements were noted in the intervention group for arousal (P<0.001), orgasm (P = 0.008), sexual satisfaction (P<0.001), and overall FSFI score (P<0.001), which did not have a significant statistical difference until the follow-up stage. In the control group, the overall FSFI score, orgasm, and sexual satisfaction decreased at follow-up compared to those of the pretest and posttest.
Conclusion: The scores of overall FSFI and most of its domains were higher in the experimental group than in the control group, an ability that can be attributed to the effect of sexual education and counseling. It is recommended to use this non-invasive, low-cost, and easy method together with other medical procedures.
Addressing evidence needs during health crises in the province of Quebec (Canada): a proposed action plan for rapid evidence synthesis
Authors: Hong Quan Nha , McSween-Cadieux Esther , Guillette Maxime , Manceau Luiza Maria , Li Jingjing , Granikov Vera , Pomey Marie-Pascale , Gagnon Marie-Pierre , Ziam Saliha , Dagenais Christian , Dagenais Pierre , Lesage Alain , Poder Thomas G. , Drapeau Martin , Ridde Valéry , Lane Julie
Published: April 2024

Background: The COVID-19 pandemic necessitated the rapid availability of evidence to respond in a timely manner to the needs of practice settings and decision-makers in health and social services.
Now that the pandemic is over, it is time to put in place actions to improve the capacity of systems to meet knowledge needs in a situation of crisis. The main objective of this project was thus to develop an action plan for the rapid syntheses of evidence in times of health crisis in Quebec (Canada).
Methods: We conducted a three-phase collaborative research project. First, we carried out a survey with producers and users of rapid evidence syntheses (n=40) and a group interview with three patient partners to prioritize courses of action. In parallel, we performed a systematic mapping of the literature to identify rapid evidence synthesis initiatives developed during the pandemic. The results of these two phases were used in a third phase, in which we organized a deliberative workshop with 26 producers and users of rapid evidence syntheses to identifying ways to operationalize priorities. The data collected at each phase were compared to identify common courses of action and integrated to develop an action plan.
Results: A total of 14 specific actions structured into four main axes were identified over the three phases. In axis 1, actions on raising awareness of the importance of evidence-informed decision-making among stakeholders in the health and social services network are presented. Axis 2 includes actions to promote optimal collaboration of key stakeholders in the production of rapid evidence synthesis to support decision-making. Actions advocating the use of a variety of rapid evidence synthesis methodologies known to be effective in supporting decision-making are presented in axis 3. Finally, axis 4 is about actions on the use of effective strategies to promote the dissemination, sharing, and use of rapid evidence synthesis products to support decision-making.
Conclusions: This project led to the development of a collective action plan aimed at preparing the Quebec ecosystem and other similar jurisdictions to meet knowledge needs more effectively in times of health emergency. The implementation of this plan and its evaluation will enable us to continue to fine-tune it.
Association Between dietary iron Levels and all-cause and cancer-cause mortality: a Prospective Cohort Study
Authors: Yi Jiahong , Guo Hui , Yang Lin , Jiang Chang , Duan Junyi , Ju Xue , Zhao Yue , He Wenzhuo , Xia Liangping
Published: April 2024

Although there are many studies concentrate on the connection between dietary iron and tumors. Few studies elucidated the association between total dietary iron and all-cause or cancer-cause mortality. Conclusions about how total dietary iron influences all-cause/cancer-cause mortality were paradoxical. Our study collected dietary iron and survival data from National Health and Nutrition Examination Survey (NHANES) 1999-2019. Multivariate Cox proportional risk models and subgroup analysis were used to assess the relationship between dietary iron and all/cancer-cause death. Restricted Cubic Samples (RCS) were used to fit the non-linear relationship between them. Dietary iron was a protective factor against all-cause mortality ( p for trend = 0.004), as well as cancer-cause mortality( p for trend = 0.028). Dietary iron content had a nonlinear relationship with and all-cause mortality (p for overall < 0.001; p for non-linearity < 0.001) with an "L" curve, so as to the cancer-related death (p for overall=0.002，p for non-linearity= 0.046). The nonlinear association of dietary iron and cancer-cause mortality differed from all/cancer-cause mortality.Our study found that dietary iron was a protective factor for death of all-cause and cancer in population and they had an "L" shaped nonlinear curves. All-cause/cancer mortality was attenuated by dietary iron in people who were aged <=65 years, males, Non-Hispanic White and Non-Hispanic Black, as well as people without hypertension or diabetes mellitus(DM).
Seismic response analysis of cliff-attached isolated structures considering SSI effect under long-period ground motion in the far field
Authors: Yang Zhuoxin , Liu Dewen , Ling kangjie , Ban TAO , Zhao Yunlong , Sun Rui , Sun Weiwei
Published: April 2024

Cliff-attached constructions are buildings that are directly connected to and aligned with the vertical faces of mountains. The building is built with its backs on the cliff. Due to its complex grounding relationship, structural stress and deformation characteristics differ from conventional structures, so the SSI effect must be considered. Long periods, extended durations, and rich low-frequency components relative to ordinary ground vibration characterize long-period ground vibration in the far field. For a seismic isolation-type structure with a long period, it is especially complicated to consider the SSI (soil-structure interaction) effect, which needs to be explored in depth. On this basis, two structural configurations are established for analysis: the cliff-attached inter-story isolated structure and the double-story isolated structure. A comparison of these arrangements is conducted both with and without considering the impacts of soil-structure interaction. An examination of the extent of influence from regular earthquakes and far-field long-period earthquakes on the cliff isolation structure is performed under three-dimensional ground motion stimulation. The results suggest that the seismic reaction of cliff isolation structures to far-field long-period earthquakes exceeds that of conventional earthquakes. Particularly evident under three-dimensional ground motion conditions, notably during far-field harmonic-like seismic events, and the response is particularly significant. When factoring in the Soil-Structure Interaction (SSI) effect, it becomes apparent that the response of the cliff-attached structure is most pronounced when situated atop a soft soil foundation. As the soil stiffens, the damping efficacy of the double-story isolated structure decreases, though it continues to outperform the inter-story isolated structure. In addition, accounting for the SSI effect enhances the seismic response of cliff-attached isolation structures, especially in part connected to a mountain body that experiences obvious stress concentration and deformation, which should be thoroughly addressed during the structural design process. The improved stability of the double-story isolated structure's isolation bearings enables effective mitigation of tensile stress within the bearings, thus alleviating the problem of excessive tensile stress, and at the same time reducing the risk of the high-rise structure toppling under rare earthquakes.
Xanthohumol inhibits osteosarcoma proliferation, migration, and invasion via EFEMP1/PI3K/AKT axis
Authors: Wang Yun , Yan Lei , Li RuoQi , Lian Jing , Wu ZhuangZhuang , Sun XiaoJuan , Lv Zhi
Published: April 2024

Background
Osteosarcoma (OS) is a tumor of bone. Xanthohumol (XN) has been found to have antitumor effects. However, it is not known whether XN can prevent the development of OS.
Method
The malignant phenotypes of OS cell lines were evaluated using CCK-8, clone-formation, EdU, Transwell, and wound-healing assays. The molecular mechanism of XN action was investigated by transcriptome sequencing. mRNA levels in OS cells were examined by q-PCR and protein by western blotting and immunofluorescence, while Ki-67 and PCNA levels in tumors were assessed using immunohistochemistry.
Results
XN dose-dependently blocked proliferation, migration, and invasion in OS cell lines. Transcriptome sequencing revealed that EFEMP1 expression was significantly reduced after XN treatment, which was shown by rescue assays to have a tumor-suppressive effect. Reduced levels of EFEMP1/PI3K/AKT axis after XN treatment were demonstrated by western blotting.
Conclusion
XN blocks OS tumorigenic behavior by inhibition of the EFEMP1/PI3K/AKT axis.
Two Critiases and Atlantis From the history of Athenian oligarchic thought
Authors: Суриков И.Е.
Published: April 2024

Вопрос о том, в чьи уста вложена Платоном в «Тимее» и «Критии» легенда об Атлантиде дискуссионен. Согласно традиционной точке зрения, рассказывающий ее Критий тождественен известному олигарху конца V в. до н.э. Критию, сыну Каллесхра (дяде Платона), в 404–403 гг. до н.э. возглавлявшему репрессивный режим «Тридцати тиранов» в Афинах. Однако такая идентификация Крития вышеупомянутых диалогов порождает непреодолимые хронологические трудности. В свое время по эпиграфическим данным стал известен другой Критий (сын Леаида), дед «тирана», и крайне велика вероятность того, что именно он выведен Платоном в ка-честве действующего лица «Тимея» и «Крития». Обоснованию этого тезиса посвящена эта часть статьи. В том случае, если он верен, перед нами предстает целая семья, в которой крайне-олигархические воззрения передавались по наследству. Данное положение хорошо согласуется с тем фактом, что еще один представитель этой семьи – Каллесхр (отец младшего Крития и сын старшего) – тоже был политиком-олигархом.

Debatable is the question as to into whose mouth the Atlantis legend of the Timaeusand Critias was put by Plato. According to the traditional opinion, Critias, who tells it, is identical with the noted late fifth-century B.C. oligarch Critias son of Callaeschrus (Plato’s uncle), who was at the head of the repressive “Thirty tyrants” regime in Athensin 404–403 B.C. However, such an identification of Critias gives rise to very serious and insurmountable chronological difficulties. Some time ago, another Critias (son of Leaides), the “tyrant”’ grandfather, became known from epigraphic data, and extremely likely is possibility that it is he who was depicted by Plato as a character of the Timaeus and Critias. This part of the article is devoted to the substantiation of this thesis. If it is correct, an entire family appears before us, in which extremely oligarchic position was hereditary. Such a situation is well agreed with the fact that another member of the family, Callaeschrus (father of the younger Critias and son of the elder one) was also an oligarchic politician.
The Fictional and Real History: Legitimation of Yi Seong-gye (Taejo, 1392-1398), the Founder of the Korean Kingdom of Joseon (1392-1897)
Authors: Чеснокова Н.А.
Published: April 2024

В статье анализируется, как в корейских исторических источниках XV в. отражен приход к власти Ли Сонге (Тхэджо, 1392–1398) – основателя корейского государства Чосон (1392–1897). Цель исследования – выявить способы легитимации власти в средневековой Корее. Рассмотрены способы легитимации власти, которые предпринимались как самим Ли Сонге, так и его потомками позднее. Было выявлено, что легитимация власти Ли Сонге опиралась одновременно на конфуцианскую традицию, буддизм и собственные корейские представления об идеальном правителе.

The article focuses on the descriptions of Yi Seong-gye (Taejo, 1392-1398), the founder of the Korean Kingdom of Joseon (1392-1897),’s enthronement in various Korean source written in the 15th century by Korean intellectuals. The main goal of the study is to describe ways of legitimating royal power in medieval Korea. To achieve this task, I characterized the ways Yi Seong-gye and his later disciples used to prove his excellence. The conclusion of the study explains that Yi Seong-gye’s legitimacy was supported by Confucian tradition, Buddhist religion and rituals, and unique Korean ideas of a “great ruler”.
Austrian Federal Theatres as an Object of Cultural Policy, 1918-1945: Survival, Adaptation, Cultural Capital
Authors: Головлев А.И.
Published: April 2024

В данной статье Австрийские Федеральные театры рассматриваются как крупнейшая организационная единица австрийской культурной политики с точки зрения её концептуализации, применения и анализа. Долголетие этого театрального конгломерата скорее объясняется зависимостью от траектории и доминирующими моделями мышления в бюрократии, культурной среде и обществе Австрии чем настоящей борьбой за экономическую эффективность. В первой половине XX в. Федеральные театры пережили две мировые войны, революцию, экономический кризис и установление двух диктатур. Значительный культурный капитал театров, консервативные тенденции в менеджменте, а также способность абсорбировать и нейтрализовать перемены в экономической и политической обстановке помогли театрам преодолеть повороты краткосрочной конъюнктуры. Культурный капитал устойчиво превалирует над экономическими и политическими обстоятельствами.

The Austrian Federal Theatres are investigated as the largest organizational unity within Austrian cultural politics from a viewpoint of its conceptualization, implementation, and analysis. The longevity of this theatre conglomerate is better explained by path dependence and predominant patterns of thinking within Austria’s bureaucracy, cultural milieu and society than as a genuine strife for economic efficiency. In the first half of the 20th century, the Federal Theatres survived two world wars, a revolution, an economic crisis, and the establishment of two dictatorships. Theatres’ significant cultural capital, conservative tendencies in management, and the ability to absorb and neutralize changes in economic and political conditions helped theatres to overcome the vicissitudes of short-term conjuncture. Cultural capital has consistently prevailed over economic and political circumstances.
Restabelecimento Estético-Funcional de Dentes com Hipomineralização Molar-Incisivo: Relato de Caso
Authors: Veloso Paula Maria Mendes Magri , Meira Maria Fernanda Cavalcante , Díaz-Fabregat Beatriz , Fernandes Gabriela Leal Peres , Gonçalves Francyenne Maira Castro , Quinteiro Julia Paião , Danelon Marcelle
Published: April 2024

Objeti¬vos: O presente trabalho teve como objetivo relatar e descrever a condução de um caso clínico de hipomineralização molar-incisivo (HMI). Introdução: A hipomineralização molar-incisivo (HMI) é um distúrbio de desenvolvimento de origem sistêmica e etiologia desconhecida que acomete primeiros molares e incisivos permanentes. Clinicamente, o esmalte dos dentes afetados apresenta zonas de descoloração branco/opaca, amarela ou castanha. O tratamento desta alteração envolve aplicação de flúor (F), restaurações diretas até exodontias, dependendo da severidade do caso. Relato de Caso: Paciente pediátrico masculino de 10 anos de idade atendido na clínica de Odontopediatria da Universidade de Ribeirão Preto-UNAERP foi diagnosticado com HMI a partir de anamnese e exame clínico, e proposto plano de tratamento de reabilitação estética e funcional, com acompanhamento clínico. Após realizado o condicionamento da criança, esta apresentou medo, ansiedade e comportamento colaborador com reserva durante os atendimentos, portando-se com impaciência e agitação na cadeira odontológica. Diante do caso, optou-se por realizar restaurações com resina composta nos dentes 16, 26 e 11. Após o tratamento, foi possível a reabilitação funcional, estética e mastigatória do paciente, além de atenuar a sua sensibilidade, melhorando assim sua autoestima. Conclusão: Os tratamentos realizados proporcionaram uma melhora no quadro de sensibilidade do paciente e reabilitação funcional e estética dos dentes afetados pela HMI, além de atuarem ativamente na melhoria da qualidade de vida e autoestima dessa criança.
Turistlerin Plansız Satın Alma Davranışında Sosyal Medyanın Etkisi (The Effect of Social Media On The Impulse Buying Behavior of Tourists)
Authors: ÖZCAN YILMAZSOY Demet , ARSLAN AYAZLAR Reyhan
Published: April 2024

Bilgi teknolojilerinin gelişmesi tüketicilerin satın alma davranışlarında değişimlere yol açmıştır. Bazı tüketiciler önceden alacakları ürünlere karar vererek planlı bir şekilde satın alma yaparken, bazı tüketiciler ise o an gördükleri bir üründen etkilenerek plansız bir şekilde satın alma yapabilmektedir. Bu araştırmanın amacı turistlerin plansız satın alma davranışında sosyal medyanın etkisini incelemektir. Konu kapsamında hazcı ve faydacı taramanın doğrudan ve akış deneyimi ile dolaylı olarak plansız satın alma üzerindeki etkileri üzerinde durulmuştur. Çalışma, çevrimiçi anket yöntemi ile sosyal medya kanalları üzerinden gerçekleştirilmiştir. Araştırmaya katılan 422 sosyal medya kullanıcısı kolayda örnekleme yöntemi kullanılarak seçilmiştir. Araştırma sonucunda turistlerin plansız satın alma yapmalarında faydacı ve hazcı taramanın akış deneyimi üzerinde etkisi olduğu ortaya çıkmıştır. Aynı zamanda, faydacı ve hazcı taramanın tüketicilerin plansız satın alma davranışları üzerinde doğrudan etkisi de tespit edilmiştir. Bununla birlikte, sosyal medyada akış deneyimin turistlerin plansız satın alma davranışına doğrudan bir etkisi olmadığı sonucuna ulaşılmıştır.
İş Stresi ve Tükenmişlik Sendromunun Çalışan Performansı Üzerine Etkileri (The Effect of Job Stress and Burnout Syndrome on Employee Performance)
Authors: YALÇIN Büşra , YILMAZER Aydın
Published: April 2024

Bu araştırmanın amacı; iş stresi ve tükenmişliksendromunun çalışan performansı üzerine etkisini ortayakoymaktır. Araştırmanın evrenini turizm bakanlığıişletme belgesi bulunan konaklama tesislerioluşturmaktadır. Evreni temsil eden örneklem grubu ise,Sakarya ilinde faaliyet gösteren dört ve beş yıldızlı otelişletmeleri olarak belirlenmiştir. Araştırma amacıdoğrultusunda anket tekniği ile toplanmıştır. Anketformunda iş stresi ölçeği, tükenmişlik ölçeği ve işperformansı ölçeğine yer verilmiştir. Bu kapsamda 263işgörenden elde edilen veriler analiz sürecindedeğerlendirmeye alınmıştır. Araştırma verilerinden eldeedilen bulgular kapsamında, iş stresi ve tükenmişliksendromunun çalışan performansı üzerinde anlamlı biretkisi olduğu saptanmıştır. Buna ek olarak araştırmadakullanılan değişkenler arasında; yüksek, orta ve düşükşiddette bazı anlamlı ilişkilerin olduğu, bu ilişkilerinpozitif ve negatif yönlü olduğu saptanmıştır. Ayrıcaaraştırma boyutlarına ait demografik değişkenlerinbazılarında farklılıklar olduğu tespit edilmiştir.
17. Yüzyıl İstanbul Mutfağına 1640 Tarihli Narh Defterinden Bir Bakış (A Look at the 17th Century Istanbul Cuisine from the Narh Book Dated 1640)
Authors: ÇELİK YEŞİL Seher , YILDIZ Salih
Published: April 2024

17. yüzyıl İstanbul mutfağında kullanılan gıdaların tespit edilmesi amacıyla hazırlanan bu çalışmada, 1640 tarihli narh defteri dokuman incelemesinden yararlanılarak analiz edilmiştir. 1983 yılında Mübahat S. Kütükoğlu tarafından “Osmanlılarda Narh Müessesesi ve 1640 Tarihli Narh Defteri” başlığıyla günümüze gelmiş olan bu eser betimsel analizden yararlanılarak çözümlenmiştir. Eserin 247 sayfalık metin bölümünün tamamı tercüme edilerek gıda ile ilgili olan “Es’âr-ı Me’kûlât, Es’âr-ı Attârân, Es’âr-ı Eşribe ve Me’âcin” bölümleri sınıflandırmaya tabii tutulmuştur. Sonuç olarak narh defterinde toplam 275 gıdanın olduğu tespit edilmiş ve bu gıdalar 13 sınıfta toplanmıştır. İlerleyen çalışmalar için; Osmanlı Devleti’nde özellikle eksik olarak ifade edilen yüzyıl mutfaklarının araştırılması, arşiv tabanlı çalışmaların yapılması, ürün odaklı incelemelerde bulunulması, yabancı seyahatnamelerin irdelenmesi ve narh defterlerinin sentezinin yapılması önerilmektedir.
Ulusal Yazında Destinasyon İmajı Çalışmaları: Sistematik Literatür Taraması (Destination Image Studies in National Literature: A Systematic Literature Review)
Authors: KURU Duran , LEBLEBİCİ KOÇER Leyla
Published: April 2024

Destinasyon imajı kavramı, 1970'lerden beri destinasyon geliştirme ve pazarlamada oldukça etkili olmaktadır. Destinasyon imajı, turistlerin davranışsal niyetleri ve karar verme süreçlerini anlamada önemli bir rol oynamaktadır. Turistler, gerçeklikten ziyade destinasyon imajı algısına göre karar vermektedirler. Bu nedenle turizm alanında destinasyon imajı çalışmaları uluslararası yazında olduğu kadar, ulusal yazında da yaygın bir araştırma konusu olmuş durumdadır. Buradan hareketle bu çalışmada, başlığında ya da anahtar kelimelerinde “destinasyon imajı” kavramı yer alan Türkçe yayımlanmış makaleler ile ilgili mevcut bilgilerin özetlenmesi ve bu makalelerin nasıl ele alındığının incelenmesi amaçlanmıştır. Bu amaçla sistematik literatür taraması yöntemiyle TR Dizin, Dergi Park ve Google Scholar veri tabanlarında ulaşılan destinasyon imajı ile ilgili 106 makale gözden geçirilmiştir. İnceleme sonucunda, makalelerin ilk kez 2005 yılında destinasyon imajı kavramını ele aldığı tespit edilmiş, destinasyon imajıyla ilgili en çok yayın yapan derginin Journal of Tourism and Gastronomy Studies olduğu ve makalelerin 66 farklı dergide yayımlandığı belirlenmiştir. En çok kullanılan araştırma yönteminin nicel yöntem ve veri toplama tekniğinin ise anket olduğu ortaya çıkmıştır. Ayrıca İstanbul’un en sık araştırma yapılan destinasyon olduğu ve kullanılan anahtar kelimelerin destinasyon imajı, destinasyon, tekrar ziyaret etme niyeti, memnuniyet, turizm, imaj, davranışsal niyet, destinasyon pazarlaması, hizmet kalitesi, destinasyon aidiyeti, destinasyon kişiliği, destinasyon sadakati kavramlarının olduğu belirlenmiştir. Son olarak araştırmada elde edilen bulgular ışığında bazı öneriler geliştirilmiştir.
What if the Covid-19 Pandemic Never Happened Estimation of the Tourist Arrivals for 2020 Via Levenberg-Marquardt Optimization and K-Star (K ) Machine Learning Algorithms
Authors: ŞEKER Ferhat , BOZKURT Alper
Published: April 2024

Based on the probability theory, which is used to model uncertainty and randomness in real-world situations, the study aims to understand the impact of uncertain conditions, such as the Covid-19 pandemic, on the accuracy of the algorithms and the resulting losses to a country's tourism industry. The contribution of this paper to the international body of knowledge is twofold: firstly, it advances theoretical understanding of the use of probability theory in modelling real-world problems; and secondly, it offers a methodological approach for estimating tourist arrivals that accounts for the impact of extreme events. To achieve these aims, the Levenberg-Marquardt optimization was first applied to determine the optimal coefficients of the exponential function for estimating tourist arrivals from 1950 to 2020. Next, the K-Star machine learning algorithm was applied to the dataset with and without Covid-19 cases to estimate tourist arrivals.
Turizmde Dijitalleşmenin Olumlu-Olumsuz Etkileri Üzerine Bir Değerlendirme (An Evaluation on the Positive and Negative Effects of Digitalization in Tourism)
Authors: KAHRAMAN Gamze , İNCESU Ali Caner , KÜÇÜKERGİN Fulden Nuray
Published: April 2024

Bu çalışma dijital dünyanın turizm sektörüne yansımalarını ele almaktadır. Gelişen endüstriyel uygulamaların turizmin temel bileşenleri arasında yer alan ulaşım, konaklama, acentecilik ve rehberlik faaliyetlerinde sağladığı kolaylıklar kaleme alınmış, daha sonra turizmin ana bileşenlerini oluşturan bahse konu sektörlerde dijitalleşmenin getirdiği bazı olumsuz durumlara yer verilmiştir. Turizmde dijitalleşme ulaşım ve konaklama sektörlerinde genel olarak müşteri memnuniyeti ve konfor ve operasyonel kolaylıklara vesile olsa da bakım-onarım vb. ek maliyetlere, nitelikli teknik personel istihdamı sorunlarına ve siber güvenlik gibi problemlere yol açabileceği değerlendirilmiştir. Dijitalleşmenin seyahat acenteleri bakımından ciddi problemlere yol açacağı öngörülmese de birtakım sistemsel sorunlar yaşanabileceğine vurgu yapılmıştır. Profesyonel turist rehberleri açısından dijitalleşmenin turist bireyler ve rehberler arasında iletişimi minimuma indirebileceği değerlendirilmiş, Dijital rehberlik cihazlarının gerçek bir profesyonel rehber deneyimi yaşatmayacağına vurgu yapılmıştır. Netice olarak, dijitalleşmenin turizm sektörüne olan olumlu katkıları ve olumsuz sonuçlarının dengeli bir şekilde değerlendirilmesi sonucuna varılmıştır.
Evaluation of the strength performance of the steering system of hybrid off-road vehicles
Authors: Li Yue , Fang Jinrong , Li Song , Niu Zhihui
Published: April 2024

In response to the strength performance requirements of the new energy Off road Vehicle steering system, this article analyzes and studies the strength performance and failure modes of the new energy Off road Vehicle steering rod based on a certain new energy Off road Vehicle model through simulation, bench experiments, and vehicle strength testing teams. Based on various vehicle misuse conditions, the force law of the steering rod under different vehicle driving conditions was analyzed, and a load spectrum for the steering rod strength bench test was developed to meet the actual vehicle usage conditions. The results indicate that the steering rod strength failure is mainly manifested as bending failure of the compression rod under alternating tension and compression conditions. Finally, based on the stability principle of the compression rod, the requirements for the strength performance index of the steering rod are proposed. The research results can provide certain technical support for the strength assessment of the vehicle steering rod.