bluuebunny/crossref_metadata_2025 huggingface dataset:
General Considerations
Authors: Becht Charles
Published: September 2021

The Code includes six categories of fluid service, which provides a means of discriminating among possible degrees of hazard. Less stringent design, examination, and testing are permitted for fluid service of lower hazard (Category D) and more stringent requirements are applied for more hazardous fluid service (Normal, Category M, Elevated Temperature and High Pressure). High Purity fluid service provides requirements needed for piping systems requiring a certain level of cleanness.
Design Conditions and Criteria
Authors: Becht Charles
Published: September 2021

Design conditions in ASME B31.3 are specifically intended for pressure design. The design pressure and temperature are the most severe coincident conditions, defined as the conditions that result in the greatest pipe wall thickness or highest required pressure class or other component rating. Design conditions are not intended to be a combination of the highest potential pressure and the highest potential temperature, unless such conditions occur at the same time.
Design for Sustained and Occasional Loads
Authors: Becht Charles
Published: September 2021

The wall thickness of pipe is nearly always selected based on the thickness required for internal pressure and allowances. The piping is then supported sufficiently such that the longitudinal stress (the stress in the axial direction of the pipe) is within Code limits and deflection is w ithin acceptable limits.
Flexibility Analysis
Authors: Becht Charles
Published: September 2021

Piping flexibility analysis is also known as piping stress analysis. Neither phrase satisfactorily describes all that is involved in this piping design discipline. In flexibility analysis, the response of the system to loads is calculated. The objectives of flexibility analysis are to calculate stress in the pipe; loads on supports, restraints, and equipment; and displacement of the pipe. It is essentially a beam analysis model on pipe centerlines. The fundamental principles include the following:
Back Matter
Authors: Kollmann Karl , Douglas Calum E. , Gülen S. Can
Published: September 2021

This back matter contains the Endnotes.
Bearing Design and Lubrication
Authors: Kollmann Karl , Douglas Calum E. , Gülen S. Can
Published: September 2021

High rotational speeds of the impeller call for careful bearing design and layout, not just those on the supercharger impeller shaft itself but also on any preceding shafts, which may run at lower speed. The question of whether to use plain (journal) bearings or rolling element bearings can only be decided after a complete evaluation of the overall design of the supercharger drive system in question. Journal bearings are in general smaller in outside diameter and despite the higher overall length have a lower weight than rolling element bearings. Journal bearings demand several times the lubricating oil flow rate than rolling element bearings, and they also exhibit high sensitivity to particulates in the oil and the overall quality thereof.
Interlude
Authors: Kollmann Karl , Douglas Calum E. , Gülen S. Can
Published: September 2021

In Chapters 4 to 8, the main issues encountered in the development of the centrifugal superchargers were considered. Many topics had to be ignored in order to focus exclusively on the state-of-the-art (Authors’ Note: in 1947). Specifically, the two issues of intercooling and boost pressure control were not covered in requisite depth, except where they affected the thermodynamics of the compressor operation itself.
Implications of Disability Severity on 24-Hour Movement Guideline Adherence Among Children With Neurodevelopmental Disorders in the United States
Authors: Brown Denver M.Y. , McPhee Patrick G. , Kwan Matthew Y. , Timmons Brian W.
Published: September 2021

Background: Research has established beneficial associations between 24-hour movement guideline adherence and several health outcomes in typically developing (TD) children, but these relationships are poorly understood in children with neurodevelopmental disorders (NDD). This study examined (1) 24-hour movement guideline adherence, (2) the influence of disability severity, and (3) associations between guideline adherence and health outcomes of TD children and children with NDD. Methods: This cross-sectional study used data from the 2018 and 2019 cycles of the US National Survey of Children’s Health. Parental/caregiver reports of movement behaviors (physical activity, screen time, and sleep), disability severity (limitations to daily activities), and health outcomes (general health status, anxiety, and depression) were provided for 8554 children with NDD and 19,669 TD children aged 6–17 years. Results: Children with NDD had significantly lower odds of meeting each movement behavior guideline compared to TD children; these effects were most pronounced for those who experienced consistent limitations to daily activities. Meeting at least 2 guidelines significantly lowered the odds for anxiety and depression, and increased the odds for better general health for children with NDD. Discussion: These findings suggest that degree of disability severity has a strong influence on adherence to 24-hour movement guidelines among children with NDD.
Theorizing the Moving Body in Competitive Sport
Authors: Kerr Roslyn , Espiner Seònaid Mary-Kate
Published: September 2021

This article examines an area that has received surprisingly little attention within the sociology of sport literature: the role of human movement and the ways in which it can be understood and valued. Drawing on the work of Pierre Bourdieu and Judith Butler, in this article, the authors have raised the possibility of sporting “movement capital.” The authors argued that rules and regulations produce and legitimize particular types of movements, which are then reinforced through institutionalized athlete development practices and able to be converted to symbolic capital. However, movements might also be valued as demonstrating particular traits and/or invoking emotional reactions, and be recognized as familiar. The authors concluded that, through identifying the connections between Bourdieu’s habitus and Butler’s performativity, they can understand how the value of movement is constantly in-flux, constantly regenerating as athletes imperfectly produce and reproduce recognizable movements as part of their sporting habitus.
Safety and Immunogenicity of a Newcastle Disease Virus Vector-Based SARS-CoV-2 Vaccine Candidate, AVX/COVID-12-HEXAPRO (Patria), in Pigs
Authors: Lara-Puente Jesús Horacio , Carreño Juan Manuel , Sun Weina , Suárez-Martínez Alejandro , Ramírez-Martínez Luis , Quezada-Monroy Francisco , Paz-De la Rosa Georgina , Vigueras-Moreno Rosalía , Singh Gagandeep , Rojas-Martínez Oscar , Chagoya-Cortés Héctor Elías , Sarfati-Mizrahi David , Soto-Priante Ernesto , López-Macías Constantino , Krammer Florian , Castro-Peralta Felipa , Palese Peter , García-Sastre Adolfo , Lozano-Dubernard Bernardo
Published: September 2021

Several highly efficacious vaccines for SARS-CoV-2 have been developed and are used in the population. However, the current production capacity cannot meet the global demand. Therefore, additional vaccines—especially ones that can be produced locally and at low cost—are urgently needed. This work describes preclinical testing of a SARS-CoV-2 vaccine candidate which meets these criteria.
Stratigraphy around the Cretaceous-Paleogene boundary in sediment cores from the Lord Howe Rise, Southwest Pacific
Authors: Kuroda Junichiro , Hagino Kyoko , Usui Yoichi , Bown Paul R. , Hsiung Kan-Hsi , Sakai Saburo , Hackney Ron , Saito Saneatsu , Murayama Masafumi , Ando Takuto , Ohkouchi Naohiko
Published: September 2021

During Deep Sea Drilling Project (DSDP) Leg 21, Cenozoic and latest Cretaceous sediments were recovered at Site 208 on the Lord Howe Rise, Southwest Pacific. We provide new biostratigraphic, magnetostratigraphic and chemostratigraphic data from Site 208 to constrain the stratigraphy around the Cretaceous-Paleogene (K-Pg) boundary and to determine the depth of the K-Pg boundary more precisely. Biostratigraphic data from calcareous nannofossils indicate a near-continuous succession of sediments from the mid-Maastrichtian (Late Cretaceous) to lowermost Thanetian (Paleocene) at depths of 540–590 m below seafloor (mbsf). The biostratigraphic data suggest that the K-Pg boundary corresponds to a siliceous claystone at the base of an interval of silicified sediments (576.0–576.8 mbsf). Carbonate carbon isotopic composition (δ13Ccarb) reveals a negative shift across this interval, which is consistent with global patterns of δ13C across the K-Pg boundary. Osmium concentration and Os isotopic composition (187Os/188Os) can also be used to identify the K-Pg boundary interval, as it is marked by a peak in Os concentration and a drop in 187Os/188Os values to 0.12–0.15, both of which are the result of the Chicxulub impact event. Our 187Os/188Os data show trends similar to those of coeval global seawater with the lowest value of 0.12–0.16 in the siliceous claystone (576.8 mbsf). However, the concentration of Os is low (<80 pg g−1) in this sample, which suggests that this siliceous claystone was deposited around the K-Pg boundary but may not include the boundary itself. Although the sedimentary record across the K-Pg interval at Site 208 may not be completely continuous, it nevertheless captures a time interval that is close to the Chicxulub impact event.
Ambiguous Effects of Prolonged Dietary Supplementation with a Striatal-Enriched Protein Tyrosine Phosphatase Inhibitor, TC-2153, on a Rat Model of Sporadic Alzheimer’s Disease
Authors: Rudnitskaya E. A. , Burnyasheva A. O. , Kozlova T. A. , Muraleva N. A. , Telegina D. V. , Khomenko T. M. , Volcho K. P. , Salakhutdinov N. F. , Kolosova N. G.
Published: September 2021

Alzheimer’s disease (AD) is the most common type of dementia and is currently incurable. After unsuccessful attempts to create drugs targeting the amyloid-β pathway, a search for alternative approaches and treatments targeting nonamyloid AD pathologies is currently underway. One of them is inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity, which is increased in the prefrontal cortex of AD patients. Here we examined effects of prolonged treatment of OXYS rats which mimic key signs of sporadic AD with a STEP inhibitor, TC-2153, on the progression of signs of AD. TC-2153 had an ambiguous effect on the behavior of the animals: it significantly reduced the already low locomotor and exploratory activities and enhanced anxiety-related behavior in OXYS rats but improved their long-term memory in the Morris water maze. Moreover, TC-2153 had no effect on the accumulation of the amyloid-β protein and on the STEP61 protein level; the latter in the cortex and hippocampus did not differ between OXYS rats and control Wistar rats. These results suggest that the effects of prolonged treatment with TC-2153 may be mediated by mechanisms not related to STEP. In particular, TC-2153 can act as a potential hydrogen sulfide donor and thus substantially affect redox homeostasis.
Outcomes in relation to early parenteral nutrition use in preterm neonates born between 30 and 33 weeks’ gestation: a propensity score matched observational study
Authors: Webbe James William Harrison , Longford Nicholas , Battersby Cheryl , Oughham Kayleigh , Uthaya Sabita N , Modi Neena , Gale Chris
Published: September 2021

Objective

To evaluate whether in preterm neonates parenteral nutrition use in the first 7 postnatal days, compared with no parenteral nutrition use, is associated with differences in survival and other important morbidities. Randomised trials in critically ill older children show that harms, such as nosocomial infection, outweigh benefits of early parenteral nutrition administration; there is a paucity of similar data in neonates.

Design

Retrospective cohort study using propensity matching including 35 maternal, infant and organisational factors to minimise bias and confounding.

Setting

National, population-level clinical data obtained for all National Health Service neonatal units in England and Wales.

Patients

Preterm neonates born between 30+0and 32+6weeks+days.

Interventions

The exposure was parenteral nutrition administered in the first 7 days of postnatal life; the comparator was no parenteral nutrition.

Main outcome measures

The primary outcome was survival to discharge from neonatal care. Secondary outcomes comprised the neonatal core outcome set.

Results

16 292 neonates were compared in propensity score matched analyses. Compared with matched neonates not given parenteral nutrition in the first postnatal week, neonates who received parenteral nutrition had higher survival at discharge (absolute rate increase 0.91%; 95% CI 0.53% to 1.30%), but higher rates of necrotising enterocolitis (absolute rate increase 4.6%), bronchopulmonary dysplasia (absolute rate increase 3.9%), late-onset sepsis (absolute rate increase 1.5%) and need for surgical procedures (absolute rate increase 0.92%).

Conclusions

In neonates born between 30+0and 32+6weeks’ gestation, those given parenteral nutrition in the first postnatal week had a higher rate of survival but higher rates of important neonatal morbidities. Clinician equipoise in this area should be resolved by prospective randomised trials.

Trial registration number

NCT03767634.
Is the NICE traffic light system fit-for-purpose for children presenting with undifferentiated acute illness in primary care?
Authors: Blyth Megan Hedd , Cannings-John Rebecca , Hay Alastair D , Butler Christopher C , Hughes Kathryn
Published: September 2021

Background

The National Institute of Clinical Excellence (NICE) traffic light system uses children’s symptoms and signs to categorise acute infections into red, amber and green. To our knowledge, no study has described the proportion of children with acute undifferentiated illness who fall into these categories in primary care, which is important since red and amber children are considered at higher risk of serious illness requiring urgent secondary care assessment.

Aim

To estimate the proportion of acutely unwell children presenting to primary care classified by the NICE traffic light system as red, amber or green, and to describe their initial management.

Design and setting

Secondary analysis of the Diagnosis of Urinary Tract infection in Young children prospective cohort study.

Method

6797 children under 5 years presenting to 225 general practices with acute undifferentiated illness were retrospectively mapped to the NICE traffic light system by a panel of general practitioners.

Results

6406 (94%) children were classified as NICE red (32%) or amber (62%) with 1.6% red and 0.3%, respectively, referred the same day for hospital assessment; and 46% and 31%, respectively, treated with antibiotics. The remaining 385 (6%) were classified green, with none referred and 27% treated with antibiotics. Results were robust to sensitivity analyses.

Conclusion

The majority of children presenting to UK primary care with acute undifferentiated illness meet red or amber NICE traffic light criteria,with only 6% classified as low risk, making it unfit for use in general practice. Research is urgently needed to establish as triage system suitable for general practice.
Intraosseous schwannoma of the humerus: a rarity yet warrants consideration
Authors: Kamath Jagannath , Shetty Harshit Bhaskar , Madegowda Arkesh , Bhatt Anusha S
Published: September 2021

Intraosseous schwannoma is extremely rare that it is not often considered among differential diagnosis for an osteolytic lesion, especially in long bones of the extremities. Amounting to less than 0.2% of all primary bone tumours and less than 200 cases reported so far, with only 3 cases involving the humerus, we hereby report the fourth case. In addition to its rarity, this was the only case of an intraosseous schwannoma involving the humerus bone which presented with a pathological fracture in a 45-year-old woman after sustaining a trivial trauma. Radiological examination revealed a geographic type of osteolytic lesion in distal shaft region of the left humerus. Only a histopathological examination helped in revealing and confirming the diagnosis of an intraosseous schwannoma. Treatment of the tumour with complete excision with bone graft reconstruction and osteosynthesis yields good results with very low risk of recurrence.
Palliative radiation treatment used for multiple purposes in a single irradiation field
Authors: Miura Kosei , Kurosaki Hiromasa , Utsumi Nobuko
Published: September 2021

In this case report, radiation therapy was performed for bilateral hydronephrosis developed during multiple bone metastases of breast cancer and ileus due to peritoneal dissemination. The patient’s preirradiation creatinine level was 8.2 mg/dL, which decreased by the fourth day after starting irradiation therapy. Creatinine level ultimately decreased to 0.6 mg/dL. Pain due to lumbar spine metastasis alleviated and ileus was resolved, allowing the patient to live at home for approximately 5 weeks. The effect of radiotherapy for bilateral hydronephrosis and gastrointestinal obstruction was rapid and good. Palliative radiation treatment can be used for multiple purposes, and in the present patient, we were able to prolong the vital prognosis.
ED syphilis and gonorrhea/chlamydia cotesting practices before and after the implementation of an electronic health record-based alert
Authors: Ford James S , Chechi Tasleem , Otmar Michella , Baker Melissa , Waldman Sarah , Morgan Brittany , Tan David , Tran Nam K , May Larissa
Published: September 2021

Background

The prevalence of syphilis is increasing in many countries, including the USA. The ED is often used by underserved populations, making it an important setting to test and treat patients who are not evaluated in outpatient clinical settings. We aimed to assess the utility of an ED-based syphilis and gonorrhoea/chlamydia cotesting protocol by comparing testing practices before and after its implementation.

Methods

We implemented an electronic health record (EHR) alert that prompted clinicians to order syphilis testing in patients undergoing gonorrhoea/chlamydia testing. We performed a retrospective cohort analysis that compared outcomes between the preimplementation period (January–November 2018) and the postimplementation period (January–November 2019). Patients were tested forTreponema pallidumantibody (TPA) using a multiplex flow immunoassay (MFI), and positive results were confirmed by rapid plasma reagin (RPR). The primary implementation outcome was the number of syphilis tests/month, and the primary clinical outcome was the number of syphilis diagnoses/month (defined as positive TPA MFI and RPR). We performed an interrupted time-series analysis to evaluate the effect of implementing the alert over time.

Results

Four-hundred and ninety-four and 1106 unique patients were tested for syphilis in the preimplementation and postimplementation periods, respectively. Syphilis testing increased by 55.6 tests/month (95% CI 45.9 to 65.3, p<0.001) following alert implementation. Patients tested in the postimplementation period who were tested using the alert were much younger (difference: 14 years (95% CI 12 to 15)) and were more likely to be female (difference: 15% (95% CI 8 to 21)) and African-American (difference: 11% (95% CI 5 to 17)) than patients tested by clinician-initiated testing. Presumptive syphilis diagnoses increased from 3.4 diagnoses/month to 7.9 diagnoses/month (difference, 4.5 (95% CI 2.2 to 6.9), p<0.001).

Conclusions

Our study demonstrates that use of a targeted EHR alert testing protocol can increase syphilis testing and diagnosis and may reduce clinician bias in testing.
Timing of endoscopy for acute upper gastrointestinal bleeding: a territory-wide cohort study
Authors: Guo Cosmos L T , Wong Sunny H , Lau Louis H S , Lui Rashid N S , Mak Joyce W Y , Tang Raymond S Y , Yip Terry C F , Wu William K K , Wong Grace L H , Chan Francis K L , Lau James Y W , Sung Joseph J Y
Published: September 2021

Objective

While it is recommended that patients presenting with acute upper gastrointestinal bleeding (AUGIB) should receive endoscopic intervention within 24 hours, the optimal timing is still uncertain. We aimed to assess whether endoscopy timing postadmission would affect outcomes.

Design

We conducted a retrospective, territory-wide, cohort study with healthcare data from all public hospitals in Hong Kong. Adult patients (age ≥18) that presented with AUGIB between 2013 and 2019 and received therapeutic endoscopy within 48 hours (n=6474) were recruited. Patients were classified based on endoscopic timing postadmission: urgent (t≤6), early (6<t≤24) and late (24<t≤48). Baseline characteristics were balanced with inverse probability of treatment weighting. 30-day all-cause mortality, repeated therapeutic endoscopy rate, intensive care unit (ICU) admission rate and other endpoints were compared.

Results

Results showed that urgent timing (n=1008) had worse outcomes compared with early endoscopy (n=3865), with higher 30-day all-cause mortality (p<0.001), repeat endoscopy rates (p<0.001) and ICU admission rates (p<0.001). Late endoscopy (n=1601) was associated with worse outcomes, with higher 30-day mortality (p=0.003), in-hospital mortality (p=0.022) and 30-day transfusion rates (p=0.018).

Conclusion

Compared with urgent and late endoscopy among patients who have received therapeutic endoscopies, early endoscopy was associated with superior outcomes especially among patients with non-variceal bleeding. This supports the notion that non-variceal AUGIB patients should receive endoscopy within 24 hours, but also emphasises the importance of prior resuscitation and pharmacotherapy.
The human liver microenvironment shapes the homing and function of CD4+T-cell populations
Authors: Wiggins Benjamin G , Pallett Laura J , Li Xiaoyan , Davies Scott P , Amin Oliver E , Gill Upkar S , Kucykowicz Stephanie , Patel Arzoo M , Aliazis Konstantinos , Liu Yuxin S , Reynolds Gary M , Davidson Brian R , Gander Amir , Luong Tu Vinh , Hirschfield Gideon M , Kennedy Patrick T F , Huang Yuehua , Maini Mala K , Stamataki Zania
Published: September 2021

Objective

Tissue-resident memory T cells (TRM) are vital immune sentinels that provide protective immunity. While hepatic CD8+TRMhave been well described, little is known about the location, phenotype and function of CD4+TRM.

Design

We used multiparametric flow cytometry, histological assessment and novel human tissue coculture systems to interrogate the ex vivo phenotype, function and generation of the intrahepatic CD4+T-cell compartment. We also used leukocytes isolated from human leukocyte antigen (HLA)-disparate liver allografts to assess long-term retention.

Results

Hepatic CD4+T cells were delineated into three distinct populations based on CD69 expression: CD69−, CD69INTand CD69HI. CD69HICD4+cells were identified as tissue-resident CD4+T cells on the basis of their exclusion from the circulation, phenotypical profile (CXCR6+CD49a+S1PR1−PD-1+) and long-term persistence within the pool of donor-derived leukcoocytes in HLA-disparate liver allografts. CD69HICD4+T cells produced robust type 1 polyfunctional cytokine responses on stimulation. Conversely, CD69INTCD4+T cells represented a more heterogenous population containing cells with a more activated phenotype, a distinct chemokine receptor profile (CX3CR1+CXCR3+CXCR1+) and a bias towards interleukin-4 production. While CD69INTCD4+T cells could be found in the circulation and lymph nodes, these cells also formed part of the long-term resident pool, persisting in HLA-mismatched allografts. Notably, frequencies of CD69INTCD4+T cells correlated with necroinflammatory scores in chronic hepatitis B infection. Finally, we demonstrated that interaction with hepatic epithelia was sufficient to generate CD69INTCD4+T cells, while additional signals from the liver microenvironment were required to generate liver-resident CD69HICD4+T cells.

Conclusions

High and intermediate CD69 expressions mark human hepatic CD4+TRMand a novel functionally distinct recirculating population, respectively, both shaped by the liver microenvironment to achieve diverse immunosurveillance.
Asymptotically flat black hole solutions in quadratic gravity
Authors: Saueressig Frank , Galis Mina , Daas Jesse , Khosravi Amir
Published: September 2021

Black holes constitute some of the most fascinating objects in our universe. According to Einstein’s theory of general relativity, they are also deceivingly simple: Schwarzschild black holes are completely determined by their mass. Moreover, the singularity theorems by Penrose and Hawking indicate that they host a curvature singularity within their event horizon. The presence of the latter invites the question whether these dead-end points of spacetime can be made regular by considering (quantum) corrections to the classical field equations. In this light, we use the Frobenius method to investigate the phase space of asymptotically flat, static, and spherically symmetric black hole solutions in quadratic gravity. We argue that the only asymptotically flat black hole solution visible in this approach is the Schwarzschild solution.
Customer Behavior Analysis by Intuitionistic Fuzzy Segmentation: Comparison of Two Major Cities in Turkey
Authors: Dogan Onur , Seymen Omer Faruk , Hiziroglu Abdulkadir
Published: September 2021

The vast quantity of customer data and its ubiquity, as well as the inabilities of conventional segmentation tools, have diverted researchers in search of powerful segmentation techniques for generating managerially meaningful information. Due to its noteworthy practical use, soft computing-based techniques, especially fuzzy clustering, can be considered one of those contemporary approaches. Although there have been various fuzzy-based clustering applications in segmentation, intuitionistic fuzzy sets that have the complimentary feature have appeared in limited studies, especially in a comparative context. Therefore, this study extends the current body of the pertaining literature by providing a comparative assessment of intuitionistic fuzzy clustering. The comparison was carried out with two other well-known segmentation techniques, [Formula: see text]-means and fuzzy [Formula: see text]-means, based on transaction data that belong to Turkey’s two major cities. Over 10,000 records of customers’ data were processed for segmentation purposes, and the comparative approaches were presented. According to the results, the intuitionistic fuzzy clustering approach outperformed the other methods in terms of the clustering efficiency index being utilized. The validity of the segmentation structure obtained by the superior approach was ensured via nonsegmentation variables. The comparative assessment and the potential managerial implications could be considered as a contribution to the corresponding literature. This study also compares the effects of the different parameter values used in the proposed model.
Soft decoding of short/medium length codes using ordered statistics for quantum key distribution
Authors: Khan Maqsood M. , Bari Inam , Khan Omar , Ullah Najeeb , Mondin Marina , Daneshgaran Fred
Published: September 2021

Quantum key distribution (QKD) is a cryptographic communication protocol that utilizes quantum mechanical properties for provable absolute security against an eavesdropper. The communication is carried between two terminals using random photon polarization states represented through quantum states. Both these terminals are interconnected through disjoint quantum and classical channels. Information reconciliation using delay controlled joint decoding is performed at the receiving terminal. Its performance is characterized using data and error rates. Achieving low error rates is particularly challenging for schemes based on error correcting codes with short code lengths. This article addresses the decoding process using ordered statistics decoding for information reconciliation of both short and medium length Bose–Chaudhuri–Hocquenghem codes over a QKD link. The link’s quantum channel is modeled as a binary symmetric quantum depolarization channel, whereas the classical channel is configured with additive white Gaussian noise. Our results demonstrate the achievement of low bit error rates, and reduced decoding complexity when compared to other capacity achieving codes of similar length and configuration.
Toward a more empathic relationship between humans and computing systems
Authors: Xu Xuhai , Ahuja Karan , Lu Jasmine , Czerwinski Mary , Suh Jina , Ramos Gonzalo
Published: September 2021

How might computing support us in becoming our better, more emotionally resilient selves? We explore this in an interview with the team from Microsoft Research's Human Understanding and Empathy group.
Seq Your Destiny: Neural Crest Fate Determination in the Genomic Era
Authors: Gandhi Shashank , Bronner Marianne E.
Published: September 2021

Neural crest stem/progenitor cells arise early during vertebrate embryogenesis at the border of the forming central nervous system. They subsequently migrate throughout the body, eventually differentiating into diverse cell types ranging from neurons and glia of the peripheral nervous system to bones of the face, portions of the heart, and pigmentation of the skin. Along the body axis, the neural crest is heterogeneous, with different subpopulations arising in the head, neck, trunk, and tail regions, each characterized by distinct migratory patterns and developmental potential. Modern genomic approaches like single-cell RNA- and ATAC-sequencing (seq) have greatly enhanced our understanding of cell lineage trajectories and gene regulatory circuitry underlying the developmental progression of neural crest cells. Here, we discuss how genomic approaches have provided new insights into old questions in neural crest biology by elucidating transcriptional and posttranscriptional mechanisms that govern neural crest formation and the establishment of axial level identity.
Cognitive, Systems, and Computational Neurosciences of the Self in Motion
Authors: Noel Jean-Paul , Angelaki Dora E.
Published: September 2021

Navigating by path integration requires continuously estimating one's self-motion. This estimate may be derived from visual velocity and/or vestibular acceleration signals. Importantly, these senses in isolation are ill-equipped to provide accurate estimates, and thus visuo-vestibular integration is an imperative. After a summary of the visual and vestibular pathways involved, the crux of this review focuses on the human and theoretical approaches that have outlined a normative account of cue combination in behavior and neurons, as well as on the systems neuroscience efforts that are searching for its neural implementation. We then highlight a contemporary frontier in our state of knowledge: understanding how velocity cues with time-varying reliabilities are integrated into an evolving position estimate over prolonged time periods. Further, we discuss how the brain builds internal models inferring when cues ought to be integrated versus segregated—a process of causal inference. Lastly, we suggest that the study of spatial navigation has not yet addressed its initial condition: self-location.
Evolutionary Prediction of Soil Loss from Observed Rainstorm Parameters in an Erosion Watershed Using Genetic Programming
Authors: Onyelowe Kennedy C. , Ebid Ahmed M. , Nwobia Light
Published: September 2021

Various environmental problems such as soil degradation and landform evolutions are initiated by a natural process known as soil erosion. Aggregated soil surfaces are dispersed through the impact of raindrop and its associated parameters, which were considered in this present work as function of soil loss. In an attempt to monitor environmental degradation due to the impact of raindrop and its associated factors, this work has employed the learning abilities of genetic programming (GP) to predict soil loss deploying rainfall amount, kinetic energy, rainfall intensity, gully head advance, soil detachment, factored soil detachment, runoff, and runoff rate database collected over a three-year period as predictors. Three evolutionary trials were executed, and three models were presented considering different permutations of the predictors. The performance evaluation of the three models showed that trial 3 with the highest parametric permutation, i.e., that included the influence of all the studied parameters showed the least error of 0.1 and the maximum coefficient of determination (R2) of 0.97 and as such is the most efficient, robust, and applicable GP model to predict the soil loss value.
Multislice Spiral Computed Tomography under Hybrid Iterative Reconstruction Algorithm in Staging Diagnosis of Bladder Cancer and Ceramide Glycosylation
Authors: Liu Jun , Jiang Xiaolong
Published: September 2021

This study was to discuss the application of multislice spiral computed tomography (CT) in the staging diagnosis of bladder cancer and the effect of ceramide glycosylation. The hybrid iterative reconstruction algorithm was applied. Immunohistochemistry and western blot were used to detect the normal bladder tissues (30 cases) of GCS in group 1 (100 cases) and group 2. The scanned images of all the research objects were obtained, the images with the iterative reconstruction algorithm were reconstructed, and statistical analysis on the CT value under the algorithm was conducted. The results showed that the image quality, blood vessel sharpness, average image score, signal-to-noise ratio, and radiation dose after the spiral CT and iterative reconstruction algorithm all increased, while the noise value decreased. The optical density value of glucosylceramide synthase in group 2 patients increased by 71%, and the optical density value of group 1 increased by 29%. The optical density expression of glucosylceramide synthase in group 1 patients was significantly higher than that in the control group, and there was a statistical difference between the two (

P
<
0.05

). Among the results of multislice spiral CT for tumor staging, the lesions larger than 5 cm and in the range of 1.1–2 cm in diameter were more sensitive. In 41 patients, there were multiple lesions. A total of 142 cancer lesions were found. The diameter of the tissue ranged from 0.5 to 6.8 cm, with an average diameter of 2.03 ± 0.35 cm. The optical density of glucosylceramide synthase in the group 1 was 5526, and the optical density in group 2 was 2576. The OD expression of GCS in group 1 was greatly higher in contrast to that in group 2, and there was a statistical difference between the two groups (

P
<
0.05

). The multislice spiral CT examination under this algorithm found that the diagnosis and staging accuracy of lesions with a diameter greater than 5 cm and tumor diameters in the range of 1.1 to 2 cm was higher. The image processed by the hybrid iterative reconstruction algorithm had good effect, high definition, and accuracy.
Missing Information Reconstruction of Land Surface Temperature Data Based on LPRN
Authors: Xue Chen , Wu Tao , Huang Xiaomeng , Ashrafzadeh Amir Homayoon
Published: September 2021

Temperature is the main driving force of most ecological processes on Earth, with temperature data often used as a key environmental indicator to guide various applications and research fields. However, collected temperature data are limited by the hardware conditions of the sensors and atmospheric conditions such as clouds, resulting in temperature data that are often incomplete. This affects the accuracy of results using the data. Machine learning methods have been applied to the task of completing missing data, with mixed results. We propose a new data reconstruction framework to improve this performance. Using the MODIS LST map over a span of 9 years (2000–2008), we reconstruct the land surface temperature (LST) data. The experimental results show that, compared with the traditional reconstruction method of LST data, the proportion of effective pixels of the LST data reconstructed by the new framework is increased by 3%–7%, and the optimization effect of the method is close to 20%. The experiment also discussed the influence of different altitudes on the data reconstruction effect and the influence of different loss functions on the experimental results.
Securing Open Banking with Model‐View‐Controller Architecture and OWASP
Authors: Kellezi Deina , Boegelund Christian , Meng Weizhi
Published: September 2021

In 2015, the European Union passed the PSD2 regulation, with the aim of transferring ownership of bank accounts to the private person. As a result, Open Banking has become an emerging concept, which provides third‐party financial service providers open access to bank APIs, including consumer banking, transaction, and other financial data. However, such openness may also incur many security issues, especially when the data can be exposed by an API to a third party. Focused on this challenge, the primary goal of this work is to develop one innovative web solution to the market. We advocate that the solution should be able to trigger transactions based on goals and actions, allowing users to save up money while encouraging positive habits. In particular, we propose a solution with an architectural model that ensures clear separation of concern and easy integration with Nordea’s (the largest bank in the Nordics) Open Banking APIs (sandbox version), and a technological stack with the microframework Flask, the cloud application platform Heroku, and persistent data storage layer using Postgres. We analyze and map the web application’s security threats and determine whether or not the technological frame can provide suitable security level, based on the OWASP Top 10 threats and threat modelling methodology. The results indicate that many of these security measures are either handled automatically by the components offered by the technical stack or are easily preventable through included packages of the Flask Framework. Our findings can support future developers and industries working with web applications for Open Banking towards improving security by choosing the right frameworks and considering the most important vulnerabilities.
Acute Myopericarditis after COVID-19 Vaccine in Teenagers
Authors: Ambati Shashikanth , Colon Michael , Mihic Maya , Sanchez Javier , Bakar Adnan
Published: September 2021

Background. There have been an increasing number of reports of myocarditis and pericarditis in adolescents and young adults after coronavirus disease 19 vaccinations. The pathophysiology of myocarditis after this vaccination is indeterminate currently. The problem is a relatively new phenomenon, and so there are no current guidelines on how to manage these cases of myopericarditis. We intend to describe our management in these two cases so that it can help guide pediatricians, intensivists, and cardiologists taking care of similar cases. Case Summaries. The first case is a young adolescent who presented with chest pain after receiving his second dose of coronavirus disease 19 vaccination with no other symptoms. His troponin was found to be 40 ng/mL. He had a normal echocardiogram and chest CT angiogram. His troponins trended down with symptomatic pain management after 3 days. The second case is another adolescent who presented with fever, fatigue, headache, and chest pain 3 days after receiving his second dose of coronavirus vaccine. His troponin was elevated to 5 ng/mL, electrocardiogram with ST segment elevations, and mildly decreased systolic function on echocardiogram. His troponins and electrocardiogram were normalized in 3 days at the time of his discharge. Conclusion. The clinical course of vaccine-associated myocarditis appears favorable as both our patients have responded well to medications and rest with prompt improvement in symptoms with full recovery. The experience remains limited at this time regarding the investigations, management, and follow-up of this novel clinical entity. It is vital for all the health care providers taking care of adolescents to have knowledge about this phenomenon and make correct diagnosis in those presenting with chest pain after COVID-19 vaccine and in preventing unnecessary invasive procedures such as coronary angiogram to rule out acute coronary syndromes.
Implant Stability Changes for Nonsubmerged and Submerged Protocols for a Single Implant Mandibular Overdenture Using Ball Attachment
Authors: Salah Ahmed , Foda Karim , Abdalla Mohamed Farouk , Aal Marwa Abdel , Naguib Amr , Nabi Nouran Abdel
Published: September 2021

Objectives. To compare the changes in implant stability for the nonsubmerged (NS) and submerged (S) protocols for the single implant retained mandibular overdenture using ball attachment throughout a 24-month follow-up. Materials and Methods. Eighty completely edentulous patients were seeking to improve retention of their lower complete denture by installing a single implant in the midline of the completely edentulous mandible. At the day of implant installation, patients were randomized into 2 groups using sealed envelopes: the nonsubmerged (NS) and submerged (S) group. After a 3-month healing period, all patients were randomized using sealed envelopes into ball attachment and CM-LOC attachment. The Periotest readings (PTV) was recorded using the Periotest M device and was recorded every 3 months for the first year and then annually in the second year. The scope of this clinical trial focused only on results of the ball attachment. The Mann–Whitney U test was used for comparison between study groups for independent samples. Two-sided

p

values less than 0.05 was considered statistically significant. Results. There was no statistically significant difference in the mean change in PTV reading between the NS and S group at the different follow-up intervals. Initially, at the day of pickup (baseline) and 3-month follow-up, the mean PTV reading for the NS was greater than that of the S group (−4.471 ± 1.489, −4.391 ± 1.4727 (

p
=
0.913

)), while the S group has shown a greater improvement in PTV than the NS group after 6-month follow-up and continued throughout the 24-month follow-up (−5.730 ± 1.7804, −50855 ± 1.2581 (

p
=
1

)). Conclusion. Both the nonsubmerged and the submerged healing protocol have shown reliable Periotest readings using ball attachment for a single implant retained overdenture. The submerged group has resulted in a greater improvement in Periotest readings after the 12- and 24-month follow-up period when compared to the nonsubmerged group although this improvement was not statistically significant.
A Bio-Inspired Method for Engineering Design Optimization Inspired by Dingoes Hunting Strategies
Authors: Peraza-Vázquez Hernán , Peña-Delgado Adrián F. , Echavarría-Castillo Gustavo , Morales-Cepeda Ana Beatriz , Velasco-Álvarez Jonás , Ruiz-Perez Fernando
Published: September 2021

A novel bio-inspired algorithm, namely, Dingo Optimization Algorithm (DOA), is proposed for solving optimization problems. The DOA mimics the social behavior of the Australian dingo dog. The algorithm is inspired by the hunting strategies of dingoes which are attacking by persecution, grouping tactics, and scavenging behavior. In order to increment the overall efficiency and performance of this method, three search strategies associated with four rules were formulated in the DOA. These strategies and rules provide a fine balance between intensification (exploitation) and diversification (exploration) over the search space. The proposed method is verified using several benchmark problems commonly used in the optimization field, classical design engineering problems, and optimal tuning of a Proportional-Integral-Derivative (PID) controller are also presented. Furthermore, the DOA’s performance is tested against five popular evolutionary algorithms. The results have shown that the DOA is highly competitive with other metaheuristics, beating them at the majority of the test functions.
TAFRO Syndrome and Elusive Diagnosis of Idiopathic Multicentric Castleman Disease Treated with Empiric Anti-Interleukin-6 Therapy
Authors: Williams Corinne , Phillips Alexis , Aggarwal Vikram , Slonim Liron Barnea , Fajgenbaum David C. , Karmali Reem
Published: September 2021

TAFRO syndrome is defined by the presence of thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis/renal dysfunction (R), and organomegaly (O) and can be seen with idiopathic multicentric Castleman disease (iMCD) or as an isolated process without iMCD. Although the diagnosis of iMCD in patients with TAFRO can be challenging to make, iMCD should remain high on the differential diagnosis. Similar to iMCD, the pathophysiology of TAFRO is not well understood but is thought to be related to hypercytokinemia, with interleukin (IL)-6 playing a pivotal role. Anti-IL-6 monoclonal antibody therapy is an effective treatment modality for iMCD, but to date, there is no clear guidance on treatment of TAFRO in the absence of definitive diagnosis of iMCD, leading to suboptimal management and high morbidity. We report a case of TAFRO syndrome and demonstrate benefit with the empiric use of anti-IL-6 antibody therapy in the context of delayed diagnosis of iMCD.
Serial Monitoring and Hyperimmunoglobulin versus Standard of Care to Prevent Congenital Cytomegalovirus Infection: A Phase III Randomized Trial
Authors: Devlieger Roland , Buxmann Horst , Nigro Giovanni , Enders Martin , Jückstock Julia , Siklós Pal , Wartenberg-Demand Andrea , Schüttrumpf Jörg , Schütze Joachim , Rippel Natascha , Herbold Marlis , Niemann Gabriele , Friese Klaus
Published: September 2021

Introduction: Nonrandomized studies support the potential of cytomegalovirus hyperimmunoglobulin (CMV-HyperIg) in preventing maternofetal CMV transmission, but prospective interventional studies show equivocal results. We pre­sent a prospective phase-III international randomized open-label trial on the potential effect of CMV-HyperIg following serial monitoring of CMV serostatus. Methods: CMV-seronegative pregnant women (gestational age [GA] <14 weeks) were 1:1 randomized to monthly CMV-serostatus monitoring and CMV-HyperIg upon seroconversion (treatment), or routine prenatal care with CMV-serostatus testing at end of pregnancy (control). Ethical considerations required that control subjects with confirmed seroconversion be offered Cytotect®. The primary endpoint was the proportion of fetuses/newborns with congenital CMV infection. Secondary endpoints included neonatal CMV disease and safety during the 24-month follow-up. Results: The treatment arm counted 4,800 randomized subjects: 52 seroconverted (median GA 24 [11–35] weeks), of which 45 completed follow-up. The control arm counted 4,735 randomized subjects: 42 seroconverted, of which 34 completed follow-up (evaluable data for 28 newborns) and 8 subjects chose off-label Cytotect®. Congenital CMV rates were 13/28 newborns (46.4% [CI 27.51; 66.13]) vs. 16/45 newborns (35.6% [CI 21.87; 51.22]) in control and treated arms, respectively (p = 0.46). Newborn CMV disease was mostly mild and spontaneously resolving. There were no major safety concerns. The target sample was not reached within an acceptable time frame. Conclusions: Serial monitoring of CMV serostatus with CMV-HyperIg treatment was associated with a mild nonsignificant reduction in the vertical CMV transmission rate. Studies on the optimal preventive strategy are hampered by epidemiological and ethical challenges and should focus on GA-dependent transmission rates and accurate dating of infection.