bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects and mechanism of filler content on thermal conductivity of composites: a case study on plasticized polyvinyl chloride/graphite composites
Authors: Zhang Han , Yang Zhangbin , Su Keshun , Huang Wenxin , Zhang Jun
Published: May 2022

Thermally conductive polymer composites that retain mechanics and processing properties have attracted significant attention because of promising high thermal conductivity. Herein, plasticized polyvinyl chloride (P-PVC)/graphite composites were successfully prepared via melt blending. Following the addition of graphite rising from 0 to 300 phr, the thermal conductivity of P-PVC/graphite composites increases from 0.18 to 3.01 W m−1 K−1. The thermal conductivity of P-PVC/graphite composites with 300 phr graphite is 17 times that of the P-PVC matrix. P-PVC/graphite composites with high thermal conductivity have excellent performance in thermal management for LEDs. Therefore, the high thermal conductivity allows for the LED’s temperature to drop 44%, compared with the P-PVC matrix, at 1.5 V. The notably cooling effect provides the ideas for the future application of the P-PVC/graphite composites in the thermal management for electronic components.
Logonomic signs as three-phase constraints of multimodal social semiosis
Authors: Fomin Ivan
Published: May 2022

The article introduces the concept of the logonomic sign as an elaboration on Hodge and Kress’s promising yet under-examined ideas about logonomic systems. Logonomic signs are defined as socially devised signs that constrain multimodal semiosis by restricting who is able to produce what signs under what circumstances. Based on the Peircean categories, the functioning of logonomic signs is modeled as a three-phase process of (1) logonomic understanding (production of the meaning that is the Initial Interpretant of a logonomic sign), (2) logonomic actualization (production of the actual semiotic event that is the Dynamical Interpretant of a logonomic sign), and (3) logonomic reproduction ([re]production of the semiotic Habit that is the Final Interpretant of a logonomic sign). Based on Kull’s theory of evolution of semiotic systems, logonomic signs are theorized as mechanisms of retention and standardization of semiotic Habits. The mechanism of reproduction of logonomic signs is modeled as a sign in which past logonomic semioses function as Objects by being iconically represented by similar current logonomic semioses functioning as Representamens, and in which future logonomic semioses are produced as Interpretants. The methodological potential of the proposed concept is discussed in the context of the integrative transdisciplinary capacity of semiotics in social research.
The Predicament of Japanese Energy and Climate Policy
Authors: Uyanik Sirri
Published: May 2022

Japanese energy policy has persistently promoted nuclear energy, even since the Fukushima disasters and despite failures in meeting its objectives. However, since Fukushima local actors (prefectures, towns, courts, and local activists) have grown more powerful with respect to policy and implementation. This paper analyzes the role of local civic actors in energy policy. A wide variety of literature is drawn on. The main finding is that, after successfully resisting nuclear restarts, local actors now understand that the future lies in renewables. Thus, the potential for local civic engagement to influence sustainable energy policy needs to be explored. The input and support of local communities are needed to strengthen the country’s energy security requirements and its pursuit of climate goals.
Today’s Children, Tomorrow’s Meals
Authors: Fikry Noha
Published: May 2022

Based on ethnographic fieldwork, this research explores rooftops as gendered spaces where women practice what I propose calling “bread-nurturing,” a gendered labor through which women secure and provide nutritious and delicious food for the family. Much of this food is cultivated on rooftops in a long-standing social practice of raising chickens, ducks, goats, and other animals on the roofs of family dwellings. I argue that rooftops are extensions of kitchens in which women practice their intimate knowledge of household food. Rather than simply pushing for an understanding of rooftops as gendered spaces, however, I regard rooftops as a pivotal resource for understanding values and relations of food and taste in Egypt.
Резонансна структура перерізів розсіяння повільних електронів на атомі кальцію
Authors: Gedeon V.F. , Lazur V.Yu. , Gedeon S.V. , Yehiazarian O.V.
Published: May 2022

З використанням розширеної БСР-версiї R-матричного методу проведено систематичне дослiдження розсiяння електронiв на нейтральному атомi кальцiю в дiапазонi енергiй зiткнення до 4,3 еВ. Для точного представлення хвильових функцiй мiшенi використовується метод сильного зв’язку з наборами залежних вiд терму неортогональних орбiталей та сплайн-представленнями для базисних функцiй. Розклад для сильного зв’язку включає 39 зв’язаних станiв нейтрального кальцiю, що охоплюють усi стани вiд основного до 4s8s 1S. Детально дослiджено складну резонансну структуру проiнтегрованих за кутом повних перерiзiв пружного е + Са-розсiяння та збудження станiв 4s4p 3Po, 3d4s 3De, 3d4s 1De, 4s4p 1Po і 4s5s 3Se атома Ca електронним ударом. Спостережуванi структури пов’язано з конкретними автовiдривними станами системи налiтаючий електрон + атом Ca. Визначено положення i ширини виявлених резонансiв та проведено їхню спектроскопiчну класифiкацiю.
Measuring Peace of Heart: The Development and Validation of Taṭmainn al-Qulūb Scale (TQS)
Authors: Rusdi Ahmad , Rumiani Rumiani , Afsari Nyda , Latifa Rena
Published: May 2022

Peace of heart is an inner spiritual experience that generates an emotional feeling of harmony. Peace of heart (taṭmainn al-qulūb) is an important aspect applicable for the life of the Muslim community as a treatment for the psychological problems of the modern era, mainly due to the absence of peace. Thus far, no research has been done on the development of peace of heart to capture the uniqueness, specific aspect, and distinctive aspect of peace in Muslim community. A total of 744 respondents responded to this research. Six experts were involved to examine item wording in this research (CVR= .67-1.00). This study has found that the TQS consists of two components (al-sukūn and al-yaqīn) with a good loading factor (.687-.884), Cronbach's Alpha (.844), and item consistency (.545-.857). All items had a good difficulty level and appropriate rating. Convergence validity on this scale was indicated by its correlation with The Brief Serenity Scale (r= .612). The criterion-related validity on this scale was indicated by its correlation with dhikr quality (r= .629), Islamic positive religious coping (r= .518), perceived stress (r= -.453), and sensibility (r= .103). Further studies need to be done based on the followings: 1) Examining the measurement on this topic with larger respondents having equal variance; 2) Considering gender, education level, and age in norming study of this scale; 3) Validating with other measurements to add validity information, especially discriminant validity
Indonesian Adaptation and Validation of The Child-Adolescent Perfectionism Scale – Short Form (CAPS-SF)
Authors: Marcellina Sonia , Lubis Fitriani Yustikasari
Published: May 2022

This study aimed to adapt and examine the psychometric properties of The Child-Adolescent Perfectionism Scale – Short Form (CAPS – SF) in an Indonesian sample. In Indonesia, research on perfectionism is being developed, but there is no measurement for adolescent perfectionism that can be used. Therefore, a valid and reliable measurement is needed. The Child-Adolescent Perfectionism  Scale – Short Form (CAPS – SF) developed by Bento et al. is an instrument consisting of 2 dimensions of Socially Prescribed Perfectionism and Self-Oriented Perfectionism with a total of 9 items that can measure perfectionism in children and adolescents. The adaptation process followed the guidelines established by the International Test Commission such as translation, cognitive interview, and test of the pre-final Indonesian version which involved 322 adolescents aged 13-15 years who lived in Indonesia. Reliability test using Cronbach's Alpha and CFA, which was used to measure the construct validity, showed that the nine items in adapted The Child-Adolescent Perfectionism Scale – Short Form (CAPS – SF) could be used to measure the perfectionism of Indonesian adolescents.
The Maslach-Trisni Burnout Inventory: Adaptation for Indonesia
Authors: Widhianingtanti Lucia Trisni , Luijtelaar Gilles Van
Published: May 2022

Burnout is commonly measured with the Maslach Burnout Inventory (MBI), which consists of three subscales measuring emotional exhaustion, personal accomplishment, and cynicism. We adapted the scale and then explored and confirmed the three dimensions on the Indonesian version named The Maslach-Trisni Burnout Inventory (M-TBI) with an exploratory analysis followed by Confirmatory Factor Analysis (CFA) from 822 workforces. The sensitivity for different job characteristics and demographic factors was established with analyses of variance and based on percentile scores of the subscales, three categories for burnout tendency were proposed. The scores on the three subscales were compared with those of Western countries. There are similar scores for emotional exhaustion and cynicism, but the sample score for personal accomplishment tends to be lower than the western countries. It can be concluded that the M-TBI scale is a reliable, sensitive, and efficient tool to measure the burnout tendency in the workforce in Indonesia.
Differentiating Bell’s Palsy From Lyme-Related Facial Palsy
Authors: Guez-Barber Danielle , Swami Sanjeev K , Harrison Jacqueline B , McGuire Jennifer L
Published: May 2022

BACKGROUND AND OBJECTIVES

To describe the etiology and clinical course of pediatric acute-onset unilateral peripheral facial palsy (FP), to define factors that distinguish Bell’s palsy from Lyme-related FP (LRFP), and to determine if early corticosteroid use impacts facial strength recovery in Bell’s palsy or LRFP.

METHODS

Retrospective cohort study of children 1 to 18 years old who received clinical care within our pediatric clinical care network (Lyme-endemic region) between 2013 and 2018 for acute-onset unilateral peripheral FP.

RESULTS

The study included 306 children; 82 (27%) had LRFP, 209 (68%) had Bell’s palsy, and 15 (5%) had FP of different etiology. Most children with LRFP presented between June and November (93%), and compared with Bell’s palsy, more often had a preceding systemic prodrome, including fever, malaise, headache, myalgias, and/or arthralgias (55% vs 6%, P < .001). Neuroimaging and lumbar puncture did not add diagnostic value in isolated FP. Of the 226 children with Bell’s palsy or LRFP with documented follow-up, FP was resolved in all but 1. There was no association between ultimate parent/clinician assessment of recovery and early corticosteroid use.

CONCLUSIONS

Bell’s palsy and LRFP were common causes of pediatric FP in our Lyme endemic region. Systemic prodrome and calendar month may help distinguish LRFP from Bell’s palsy at FP onset, guiding antibiotic use. Early corticosteroid use did not impact our measures of recovery, although subtle abnormalities may not have been appreciated, and time to recovery could not be assessed. Future prospective studies using standardized assessment tools at regular follow-up intervals are necessary.
Case for Animal Spirituality—Part 1
Authors: Cunningham Paul
Published: May 2022

This is the first part of a two-part article that presents the theoretical and empirical case for nonhuman animal (hereafter, ‘animal’) spirituality. Part 1 discusses the relevance of evolutionary theory and species differences for understanding animals’ capacity to have spiritual experience, conceptual issues related to defining animal spirituality, and methodological considerations pertaining to the use of analogical reasoning and animalcentered anthropomorphism as heuristic strategies in the study of animal spirituality. Behavioral and ethological evidence bearing on the existence of awareness, perceptual experience, self-awareness, and meaning-making in the absence of human language in animals is presented. Part 2 examines evidence for six biopsychosocial capabilities in animals that are proposed building blocks of human spirituality—cognition, imagination, emotion, moral sense, personality, and value-life. Part 2 concludes with a discussion of the implications of animal spirituality for society’s treatment of animals, humanizing an inhumane human biocultural world, and advancing understanding of human spirituality.
Catholic Sisters and Cornfield Activism
Authors: Clatterbuck Mark
Published: May 2022

Since 2016, the Adorers of the Blood of Christ, an international order of Catholic women, have partnered with a grassroots movement called Lancaster Against Pipelines (LAP) to resist construction of a $3B fracked-gas pipeline in rural Lancaster County, Pennsylvania. Together, the groups built an outdoor chapel blockade that became a locus of earth-honoring ceremonies and a pilgrimage site for eco-activists in the region. It also served as the focal point for a series of peaceful direct actions against pipe-line construction that resulted in twenty-nine arrests. The Adorers–LAP partnership is an important case study in a growing movement of faith-fueled environmental activism across the United States today. Specifically, it offers valuable lessons on the possibilities for creative grassroots cooperation across religious divides, the use of religious ritual as a tool of resistance, the experience of women who often lead these movements, and current trends in judicial responses to faith-inspired eco-activism.
Geographical specificity of fatty acid and multi-element fingerprints of soybean in northern China
Authors: Sheng Cui Dong , Yu Jia Hong , Qing Lai Han , Hui Wang Zhao , Xue Fei Mao
Published: May 2022

Soybean is an important food crop in China. Recently, crops cultivated in specific geographical locations have started attracting high prices. Therefore, developing a technique to identify the geographical origin of a crop is crucial to prevent fraud. In this work, we measured the contents of five fatty acids and 17 elements in soybean samples produced in Heilongjiang, the Inner Mongolia Autonomous Region, Jilin and Liaoning using gas chromatography and inductively coupled plasma mass spectrometry. Correlation analysis, principal component analysis and cluster analysis were used to identify the relationship between the metabolic fingerprint and the geographical location. Our results showed a significant correlation between the contents of fatty acids and geographical origin. Principal component analysis provided a preliminary classification of all variables. Hierarchical clustering, based on heat maps, showed that all samples could be classified based on their geographical origins. The model established by partial least squares discriminant analysis showed 89.9% predictive ability, further proving that the 14 classification indexes, comprising fatty acids and elements, could be used as molecular fingerprints to identify and distinguish soybean samples from four different production areas. Besides, pairs of soybean sample fingerprints from the four provinces were compared, and the differences in fatty acid and element contents between the provinces were explained based on the climatic environment and soil distribution. In conclusion, our method of classifying and confirming soybean production areas through fatty acid and multi-element fingerprints can potentially be used for identifying soybean of similar origins.
Circulating free DNA in hypertensive patients with high cardiovascular risk
Authors: Trofimova E. A. , Kireeva V. V. , Usoltsev Yu. K. , Kirilchik S. V. , Lepekhova S. A. , Apartsin K. A.
Published: May 2022

Aim. To evaluate the level of circulating free nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) in hypertensive patients with high cardiovascular risk.

Material and methods. The study included 70 patients, of which 51 were patients with hypertension (HTN) and 19 were healthy. The study of the level of circulating free nDNA and mtDNA was carried out using quantitative polymerase chain reaction (PCR). Additionally, demographic data, comorbidities, risk factors, heredity, results of complete blood count and biochemical blood tests, electrocardiography and echocardiography were analyzed.

Results. The level of nDNA in HN patients was significantly higher than in healthy patients: Me (LQ; UQ) — 227 (110; 370) copies/mL and 88 (62; 116) copies/ml, respectively (p<0,0001). In hypertensive patients with a very high cardiovascular risk, the level of nDNA and mtDNA was significantly higher compared to healthy participants: 294 (154; 489) copies/ml versus 88 (62; 116) copies/ml, p<0,0001; 56731 (42531; 129375) copies/mL versus 35156 (18325; 54956) copies/mL, p=0,015.

Conclusion. The level of circulating free DNA in hypertensive patients with very high cardiovascular risk is significantly increased, and therefore this parameter can be a cardiovascular risk marker.
Twenty-four-hour profile of peripheral and central blood pressure in young patients with high-normal blood pressure and hypertension
Authors: Silkina S. B. , Antropova O. N. , Osipova I. V.
Published: May 2022

Aim. To evaluate indicators of daily monitoring of peripheral and central blood pressure in young patients with high-normal blood pressure (HNBP) and essential hypertension (HTN).

Material and methods. One hundred twelve patients with HNBP or untreated hypertension aged 25-44 years were included. General clinical investigations were performed. An office blood pressure (BP) were assessed using an automatic BP monitor OMRON M2 Basic. Twenty-four-hour ambulotary BP monitoring (ABPM) on the brachial artery and aorta was carried out for 24 hours using the BpLAB system (OOO Petr Telegin) with an integrated Vasotens system. Depending on BP, patients were divided into groups: with HNBP and hypertension. Statistical processing and comparative analysis of the obtained data were carried out.

Results. HNBP group consisted of 47 patients, while the HTN group consisted of 65 patients. The mean age of patients was 34,7±3,2 years. The parameters of daytime and nighttime peripheral BP had significant differences between the HNBP and HTN groups. Aortic BP monitoring revealed following differences: in patients with HTN, central BP values during the day and at night reflected higher values compared to patients from the HNBP group. The number of dippers for peripheral systolic blood pressure (SBP) was more by a quarter (p=0,038) in the HNBP group than in the HTN group. There were no differences in the reduction of diastolic blood pressure (DBP). The reduction in aortic SBP between the groups of HNBP and HTN were comparable. Among hypertensive patients, DBP dippers on the aorta were 20% higher (p=0,04) than in the HNBP group. According to the augmentation and the amplification index reduced to heart rate, there were no significant differences between the groups.

Conclusion. Intergroup and intragroup differences were revealed depending on the types of 24-hour profile depending on peripheral and central BP. Reference values and predictive value of central BP require further research.
Multiagonists of the “incretin axis” as a promising tool for managing cardiometabolic risk in visceral obesity
Authors: Druzhilov M. A. , Kuznetsova T. Yu. , Chumakova G. A.
Published: May 2022

Currently, the world experiences an increase in obesity prevalence, resulting in an increase in the incidence of diseases in which it is one of the leading factors, primarily type 2 diabetes and cardiovascular disease. This limits the effectiveness of preventive measures and determines the need to introduce more effective approaches. Evidence of the key role of intestinal peptide hormones (incretins) in the normalization of body weight and metabolic processes after bariatric interventions became the basis for studying pharmacological methods for treating obesity and related complications aimed at the “incretin axis”. In order to achieve greater efficacy compared to monotherapy with glucagon-like peptide-1 (GLP-1) agonists, studies are performed on unimolecular multiagonists developing on the basis of GLP-1 agonists and effecting on various components of the “incretin axis” by competitive activation of numerous receptors, in first of all, receptors for glucose-dependent insulinotropic polypeptide and glucagon. This review analyzes the results of clinical trials and discusses the prospects for introduction of “incretin axis” multi-agonists for patients with visceral obesity syndrome.
Predicting the risk of left ventricular diastolic dysfunction in obesity
Authors: Chumakova G. A. , Gritsenko O. V. , Gruzdeva O. V. , Zateev A. V.
Published: May 2022

Obesity may develop heart failure with preserved ejection fraction, which is based on left ventricular diastolic dysfunction (LV DD). Currently, the search for effective predictors of LV DD is extremely relevant.

Aim. To assess the prognostic value of key and additional metabolic risk factors (RFs), neurohumoral and profibrotic factors in the development of LV DD in obese patients.

Material and methods. The study included 149 men with general obesity. The mean age was 49,7±7,9 years. The inclusion criteria was the presence of class I-III general obesity. The average body mass index was 32,9±3,6 kg/m2. The exclusion criteria were hypertension, coronary atherosclerosis, type 2 diabetes, as well as LV DD according to transthoracic echocardiography. Depending on the presence of epicardial adiposity, patients were divided into two groups: group 1 — epicardial adipose tissue (EAT) thickness ≥7 mm (n=70), group 2 — EAT <7 mm (n=31). In all patients, the following laboratory parameters were determined in blood serum using enzyme immunoassay: type I and III collagen, Procollagen I C-Terminal Propeptide (PICP), matrix metalloproteinase-3 (MMP-3), transforming growth factor β1, vascular endothelial growth factor, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-10, C-reactive protein (CRP), adiponectin, soluble leptin receptor, leptin, lipid parameters and free fatty acids (FFA). After 4,7±0,3 years, echocardiography was repeated in order to assess LV diastolic function.

Results.  Comparative analysis of metabolic risk factors revealed a significant increase in the level of total cholesterol (p=0,001), low-density lipoprotein cholesterol (LDL-C) (p<0,0001), triglycerides (TGs) (p<0,0001). These groups had no differences in such parameters as high-density lipoprotein cholesterol (p=0,09) and glucose (p=0,12). An increase in the level of such pro-inflammatory cytokines as TNF-α (p<0,0001), CRP (p<0,0001), IL-6 (p<0,0001) in group 1 was revealed, while differences in IL-10 (p=0,34) levels were not significant. In group 1, there was a significant increase in leptin levels (p<0,0001), a decrease in levels of adiponectin (p<0,0001) and leptin receptor (p=0,001). In group 1, an increase in the level of all studied profibrotic factors was revealed. After 4,7±0,3 years, repeated echocardiography revealed that selected groups were comparable in such parameters as A, E, E/A, E/e’, e’, and the peak tricuspid regurgitation velocity. There was a significant difference in left atrial volume index (p=0,0003). LV DD was detected in 20 patients. Binary logistic regression revealed the following most significant predictors of LV DD in obese patients: glucose, LDL-C, triglycerides, leptin receptor, leptin, MMP-3, FFA, PICP, and EAT thickness.

Conclusion. Thus, the following most significant predictors of LV DD in obese patients were identified glucose, LDL-C, triglycerides, leptin receptor, leptin, MMP-3, FFA, PICP, and EAT thickness.
Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases
Authors: Belik E. V. , Gruzdeva O. V. , Dyleva Yu. A. , Bychkova E. E. , Kuzmina A. A. , Ivanov S. V. , Barbarash O. L.
Published: May 2022

Aim. To determine the features of expression and secretion of plasminogen activator inhibitor-1 (PAI-1) by subcutaneous, epicardial and perivascular adipocytes depending on the complexity of coronary artery disease (CAD).

Material and methods. The study included 86 patients with CAD, including 35 with moderate atherosclerotic lesions of the coronary arteries (CA) (SYNTAX Score ≤22), 22 with severe (SYNTAX Score of 23-31 pints), 29 with extremely severe (SYNTAX Score ≥32). As a comparison group, 52 patients with heart defects were examined. During an elective surgical intervention, adipose tissue (AT) samples were obtained for subsequent cultivation and determination of PAI-1 gene expression and PAI-1 secretion in AT supernatants of various localizations. Statistical analysis was performed using Statistica 10.0.

Results. In CAD, PAI-1 production in all three types of AT and plasma PAI-1 concentration were increased compared with patients with heart defects. Epicardial AT (EAT) in CAD was characterized by the maximum levels of expression and secretion of PAI-1 relative to patients with heart defects and subcutaneous and perivascular (PVAT) fat depots. Moderate coronary involvement (adipose tissue <22) is characterized by the lowest expression and secretion of PAI-1 in all types of AT and plasma concentration of PAI-1. Direct correlations of PAI-1 expression and secretion in EAT and PVAT and plasma PAI-1 level with its secretion in EAT in patients with CAD and heart defects were revealed. A direct correlation between the plasma level of PAI-1 and its secretion in PVAT was found only in CAD.

Conclusion. In CAD, there is not only an increase in the plasma PAI-1 level, but also an increase in the expression of PAI-1 gene and the secretion of PAI-1 in all three types of AT compared with patients with heart defects. PAI-1 expression and secretion in EAT, PAI-1 plasma level, and age are predictors of severe/extremely severe coronary involvement in CAD.
Peripheral vascular lesions with the development of hand and foot skin necrosis in a patient with COVID-19: a case report
Authors: Shikina E. A. , Zemlyanoy A. B. , Kazubova E. A. , Urzhumova T. V. , Krylova N. P. , Arabidze G. G.
Published: May 2022

In the presented case report, 36-year-old female patient, who was hospitalized in the rheumatology department, developed thrombotic microangiopathy and sepsis-related coronavirus disease 2019 (COVID-19). In the department, hereditary thrombophilia was revealed: heterozygous polymorphism in the coagulation factor 5 gene (Factor V Leiden). Livedo reticularis. It is known that in October 2020, the patient had COVID-19 with bilateral pneumonitis on chest computed tomography. On examination, dry gangrene of 1, 2, 4, 5 fingers of the right hand, 2 finger of the left hand, as well as 2, 3, 4, 5 fingers of the right and left feet were diagnosed. Necrosis of the nasal tip. Surgery was performed with amputation of the affected fingers and distal feet with autodermoplasty.
Hypertension control during the COVID-19 pandemic: results of the MMM2021 in Russia
Authors: Rotar O. P. , Erina A. M. , Boiarinova M. A. , Moguchaia E. V. , Kolesova E. P. , Tolkunova K. M. , Gorshevaya A. R. , Kovalenko K. A. , Smirnova E. A. , Belenikina Ya. A. , Bikushova I. V. , Kercheva M. A. , Svarovskaya A. V. , Petrova M. M. , Kaskaeva D. S. , Shcherbina P. A. , Nikulina S. Yu. , Chernova A. A. , Levshin A. V. , Shabelsky A. O. , Zheleznyak E. I. , Kartashova E. A. , Sharapova Yu. A. , Chernykh T. M. , Derevyanchenko M. V. , Fedotov V. V. , Shaposhnikova N. Yu. , Makeeva E. R. , Ulitina O. V. , Menzorov M. V. , Dolya E. M. , Tanicheva A. A. , Konradi A. O. , Shlyakhto E. V.
Published: May 2022

Repetitive quarantines and social restrictions during the coronavirus disease 2019 (COVID-19) pandemic have negatively affected the population health in general, and the control of hypertension (HTN) in particular.

Aim. To evaluate the control of HTN in the Russian population during the COVID-19 period based on the results of screening for HTN May Measurement Month 2021 (MMM2021).

Material and methods. During May-August 2021, 2491 participants from 11 Russian regions took part in the screening. Participation was voluntary without restrictions on sex. All participants were over 18 years of age. During the screening, blood pressure (BP) was measured three times using automatic and mechanical BP monitors. In addition, a questionnaire was filled out on behavioral risk factors, comorbidities and therapy. HTN was diagnosed with systolic BP ≥140 mmHg and/ or diastolic blood pressure ≥90 mmHg and/or taking antihypertensive therapy. The questionnaire included questions about prior COVID-19, vaccinations and their impact on the intake of antihypertensive drugs.

Results. The analysis included data from 2461 respondents aged 18 to 92, of which 963 were men (39,1%). The proportion of hypertensive patients was 41,0%, while among them 59,0% took antihypertensives and 30,9% were effectively treated. In comparison with pre-pandemic period according to MMM2018-2019, the higher proportion of HTN patients in the Russian sample was revealed during MMM2021 (41,0% vs 31,3%, p<0,001) with a comparable proportion of patients receiving antihypertensive therapy (60,7% vs 59,0%, p=0,05) and treatment efficacy (28,7% vs 30,9%, p=0,36). Monotherapy was received in 44,7% of cases, while dual and triple combination therapy — in 30,9% and 14,1%, respectively. The majority of respondents (~90%) did not adjust their antihypertensive therapy during the COVID-19 pandemic.

Conclusion. According to HTN screening in Russia, there is persistent ineffective control of HTN, which may be due to both the worsening pattern of behavioral risk factors, limited access to healthcare during COVID-19, and the inertia of physicians and low adherence of patients due to the asymptomatic HTN course in the majority.
Personalized management of hypertensive patients: focus on prognostic biomarkers
Authors: Lyamina S. V. , Kalish S. V. , Lyamina N. P.
Published: May 2022

Aim. To analyze level of circulating biomarkers of plasma vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) during 3-month therapy with a fixed-dose combination of ramipril/indapamide (Konsilar-D24, AO Vertex, Russia), as well as to evaluate the antihypertensive efficacy of a fixed-dose combination of ramipril/indapamide (Konsilar-D24, JSC “Vertex”, Russia) in hypertensive (HTN) patients with type 2 diabetes (T2D).

Material and methods. This prospective open-label study included 44 patients (aged 35 to 60 years) of both sexes with essential grade 1-2 HTN and concomitant compensated T2D, who did not reach the target blood pressure (BP) level using single or dual antihypertensive therapy, as well as patients who did not take antihypertensives. All patients included in the study initially underwent a set of standard clinical, laboratory and functional examinations in accordance with the clinical guidelines for the management of patients with HTN and T2D, as well as an assessment of the level of C-reactive protein, VEGF and TNF-α. Patients were monitored and treated with Konsilar-D24 for 3 months.

Results. In 93,2% of patients, individual target BP values were achieved during the first 2-4 weeks of therapy with a fixed combination of ramipril/indapamide (Konsilar-D24). In the subsequent 3-month follow-up, the average daily BP level in all patients ranged from 129/79 mm Hg to 110/70 mm Hg. Three-month Konsilar-D24 therapy showed a decrease in microalbuminuria: the median values of microalbuminuria decreased by 2 times, and the decrease in the maximum recorded values reached 40% of the baseline. Decrease in mean TNF-α values after 3-month therapy with Konsilar-D24 was 33% of the baseline values, while the maximum recorded values during the specified period decreased by 17%. Decrease in median VEGF values after 3-month Konsilar-D24 therapy was 28%, while the maximum value decreased by 7%, the minimum — by 8%.

Conclusion. Konsilar-D24 improves the prognosis in hypertensive patients not only by reducing BP to target values, but also by reducing the level of VEGF and TNF-α biomarkers that determine the progression of endothelial dysfunction, diabetic retinopathy, and microalbuminuria.
Social impact bonds as public policy: international panorama and contributions to implementation in Brazil
Authors: Sancho Beatriu Canto , Christopoulos Tania P. , Mello Ruth Espínola Soriano de , Matos Pedro Verga
Published: May 2022

Abstract Despite being launched in 2011, the social impact bond (SIB) is an instrument under development that faces numerous challenges. This article presents the characteristics of SIBs and challenges related to their implementation as mechanisms to finance public projects with a social purpose. After a bibliographical and documentary review, three international cases of SIBs that have completed their maturity cycles, relevant for critical analysis of possible projects in Brazil, were selected. Ethical, methodological, metrics, results, and actor networks are analyzed in the three SIBs. Implications for projects in Brazil were considered from the analysis of these international cases.
Cooperação internacional para o desenvolvimento e financiamento externo para o Brasil: uma macroanálise do período entre 2000 e 2020
Authors: Pessina Maria Elisa Huber , Coelho André Pires Batista , Fadul Élvia Mirian Cavalcanti , Monteiro Augusto de Oliveira
Published: May 2022

Resumo Este artigo traz como objeto de análise os projetos e programas do setor público no Brasil que receberam financiamentos externos de organismos multilaterais e bilaterais em âmbito federal, estadual e municipal entre 2000 e 2020. Os dados analisados foram coletados no Painel da Comissão de Financiamentos Externos (Painel COFIEX) do Ministério da Economia do Brasil, categorizados e apresentados neste artigo de forma conjuntural, com o objetivo de representar um panorama sobre este objeto para os estudos da Administração Pública no país. Importante instrumento do Sistema de Cooperação Internacional para o Desenvolvimento (SCID), o financiamento internacional para o desenvolvimento obedece às agendas e diretrizes das organizações internacionais, as quais se modificaram ao longo dos anos. Dessa forma, além de explorar as principais fontes credoras, setores e unidades da federação de destino dos financiamentos internacionais para o desenvolvimento destinados ao Brasil, o artigo buscou verificar de que forma as características dos financiamentos internacionais recebidos entre 2000 e 2015 e pós-2015 refletem as agendas e diretrizes da Cooperação Internacional para o Desenvolvimento (CID) dos respectivos períodos, a saber: os Objetivos de Desenvolvimento do Milênio (ODM) (2000-2015) e os Objetivos do Desenvolvimento Sustentável (ODS) (2015-2030). Como resultado, além de apresentar uma pioneira análise exploratória dos dados, verificou-se uma inflexão dos financiamentos externos recebidos no pós-2015 pelo Brasil na direção da atual agenda e diretrizes da CID. Por fim, o artigo apresenta encaminhamentos para agendas futuras de pesquisa.
Acute kidney injury and renal replacement therapy: terminology standardization
Authors: Reis Thiago , Colares Vinicius Sardão , Rocha Eduardo , Younes-Ibrahim Mauricio , Lima Emerson Quintino de , Andrade Lucia da Conceição , Ponce Daniela , Suassuna José H. Rocco , Yu Luis
Published: May 2022

Abstract The Department of Acute Kidney Injury (IRA) of the Brazilian Society of Nephrology prepared this document for the purpose of standardizing AKI terminology and dialysis modalities in the Portuguese language for Brazil. Several terms with similar meanings have been used in AKI and its dialysis modalities, causing confusion and disparities among patients, nephrologists, health institutions, private care companies, insurance companies and government entities. These disparities can impact medical care, hospital organization and care, as well as the funding and reimbursement of AKI-related procedures. Thus, consensual nomenclature and definitions were developed, including the definitions of AKI, acute kidney disease (AKD) and chronic kidney disease (CKD). Additionally, we addressed all dialysis modalities and extracorporeal procedures related to AKI, currently approved and available in the country. The Brazilian Society of Nephrology hopes that this Consensus can standardize the terminology and provide technical support to all involved in AKI care in Brazil.
Injúria renal aguda e métodos de suporte: padronização da nomenclatura
Authors: Reis Thiago , Colares Vinicius Sardão , Rocha Eduardo , Younes-Ibrahim Mauricio , Lima Emerson Quintino de , Andrade Lucia da Conceição , Ponce Daniela , Suassuna José H. Rocco , Yu Luis
Published: May 2022

Resumo O Departamento de Injúria Renal Aguda (IRA) da Sociedade Brasileira de Nefrologia elaborou o presente documento para fins de padronização da terminologia em IRA e modalidades dialíticas na língua portuguesa para o Brasil. Diversos termos com significados semelhantes têm sido empregados em IRA e suas modalidades dialíticas, causando confusão e disparidades entre pacientes, nefrologistas, instituições de saúde, empresas privadas de assistência, seguradoras e entidades governamentais. Essas disparidades podem impactar a assistência médica, a organização e o atendimento hospitalares, assim como o financiamento e reembolso dos procedimentos relacionados com a IRA. Assim, nomenclatura e definições consensuais foram elaboradas, incluindo-se as definições de IRA, doença renal aguda (DRA) e doença renal crônica (DRC). Adicionalmente, todas as modalidades dialíticas e os procedimentos extracorpóreos relacionados a IRA, atualmente aprovados e disponíveis no país, foram abordados. A Sociedade Brasileira de Nefrologia espera que este Consenso possa padronizar a nomenclatura e prover suporte técnico para todos os atores envolvidos na assistência à IRA no Brasil.
Análise ética dos impactos da pandemia de COVID-19 na saúde de crianças e adolescentes
Authors: Santos Raíssa Passos dos , Neves Eliane Tatsch , Cabral Ivone Evangelista , Campbell Sydney , Carnevale Franco
Published: May 2022

RESUMO A pandemia de COVID-19 trouxe impactos significativos para a vida de crianças e adolescentes em todo o mundo. Considerando esse contexto, o objetivo deste artigo foi examinar como as crianças e os adolescentes no Brasil foram impactados pela pandemia à luz de uma análise ética. Para tanto, uma análise interpretativa de estudos brasileiros sobre a saúde da criança e do adolescente durante a pandemia foi realizada. A tarefa de reconhecer essa dimensão ética é importante para entender como as respostas a situações de crise, tais como a presente situação da pandemia de COVID-19, podem ser moldadas e identificar quais as prioridades de ação de acordo com todas as partes interessadas, situando a criança entre essas partes de interesse. A análise demonstrou que tanto os efeitos diretos quanto os indiretos implicam em processos de tomada de decisão que precisam utilizar e sustentar o direito de participação da criança para que a ação tomada esteja o máximo possível focada nos melhores interesses da criança. Contudo, a realidade brasileira tem demonstrado uma exclusão estrutural das vozes infantis. Recomenda-se que mais estudos sejam conduzidos a fim de aprofundar o conhecimento sobre os melhores interesses das crianças e sua participação nas ações tomadas durante a pandemia.
The Relationship of Blood Parameters with the Severity of Carbon Monoxide Poisoning
Authors: ATİŞ Şeref Emre , SARIKAYA Tevfik , YAMAÇ Ayşenur
Published: May 2022

Introduction: Carbon monoxide (CO) poisoning is one of the most common poisonings worldwide. Many studies have investigated the relationship between predictive parameters and CO poisoning severity. We aimed to investigate the relationship between blood parameter values with poor outcome in CO poisoning, and CO values measured in blood.
Methods: This is a retrospective study. Patients who had CO levels ≥ %10 in their blood gas were included in the study. Patients were divided into 2 groups as those who required hyperbaric oxygen and those who do not. Demographic data such as age, gender of the patients, as well as CO levels in the blood gases of the patients, hemoglobin, leukocyte, neutrophil, platelet counts of the blood count, and MPV and PDW values were recorded. Also, creatinine, troponin, CRP, ALT values were recorded as well.
Results: The study was conducted with 110 patients. The mean age of the patients was 46.80±18.18 years. When the parameters were examined, the median WBC count of patients with patients who required HBO therapy was 8.73[7.54-11.83], and the median WBC count of patients who did not require HBO therapy was 8.01[6.96-9.72] (p=0.038). The median lymphocyte count of patients who required HBO therapy was determined as 2.73[1.85-3.36], and this value was found to be higher than patients who did not require HBO therapy (p=0.026).
Conclusion: WBC and lymphocyte counts are higher in CO poisoning patients who required hyperbaric oxygen therapy. But these two values were not found to be independent risk factors in predicting hyperbaric oxygen therapy.
Investigating the Hepatitis E seroprevalence rates among hemodialysis patients in Turkey with pool analyses method
Authors: MIZRAKÇI Serpil
Published: May 2022

Objectives: Hepatitis E virus (HEV) is a worldwide public health problem that affects both poor and developed countries. Hemodialysis (HD) patients have been reported to be at risk for HEV infection due to the likelihood of parenteral and/or nosocomial transmission. The goal of this study was to analyze studies on HEV seroprevalence rates among hemodialysis patients and to highlight differences in disease seroprevalence between geographic regions.
Material and Methods: Published literature in English and Turkish language (full text articles or detailed abstracts) on HEV seroprevalence among hemodialysis patients from Turkey were elavuated. Google Scholar, Pubmed, the Scopus, ULAKBIM TR Dizin and the Web of Science databases were scanned by using the keywords " hepatitis E virus " or " HEV " and " hemodialysis patient " or " hemodialysis " and " seroprevalence” or "IG G” and ‘’Turkey’’or "Turkish". The publications were assessed based on their general frequency, location, region and year.
Results: The published literature on HEV seroprevalence among Turkish hemodialysis patients in both English and Turkish was reviewed. Only 11 articles were found according to the search criteria. Most of the studies (27.27%) were from the Southeast Anatolia Region. There were no studies from the Marmara and Eastern Anatolia regions. The regional seroprevalence of HEV among hemodialysis patients was highest in the Central Anatolia region (23.43%) and in the Southeastern Anatolia region (21.26%), and lowest in the Aegean region (5.95%). No studies were found in the literature search for the Marmara and Eastern Anatolia regions.
Conclusion: The median of HEV seroprevalence rate was found as 17.62% in this study. The studies were limited, and it is necessary to increase the number of publications on HEV seroprevalence in risky groups from our country.
Global Diversity in Higher Education Workforces: Towards Openness
Authors: Wilson Katie , Neylon Cameron , Montgomery Lucy , Huang Chun-Kai (Karl) , Handcock Rebecca N. , Roelofs Aniek , Hosking Richard , Ozaygen Alkim
Published: May 2022

In this article we discuss the collection and nature of diversity data relating to origin (ethnicity, race, nationality, indigeneity), gender/sex and disability in higher education institutional workforces across 24 locations within Africa, Asia, Europe, Latin America, North America and Oceania. The research emerges from the Curtin Open Knowledge Initiative project (n.d.), in which we analyse data relating to published research literature, its open access status, citations and collaborations for institutions, publishers and research funding bodies. Our project explores demographic data relating to workforce diversity and research production; we examine who creates knowledge and how diversity is transmitted through research. Collecting and analysing higher education workforce demographic diversity data reveals a global datascape with considerable variation in practices and data collected. The data reflect political and social histories, national and international policies and practices, priorities and funding. The presence and absence of public data provide an opportunity to understand differing national situations and priorities beneath the statistics. We open a conversation about how the concepts of equity, diversity and inclusion differ between groups of countries, which makes global comparisons difficult. By identifying higher education data and gaps, we also encourage institutions and countries to review their workforce demographics and their intersection with research production. Awareness of institutional diversity levels through data analysis can guide institutions towards knowledge openness.
Анализ влияния ESG-факторов на управление корпоративными инновациями и инвестициями
Authors: Дегтярева Виктория Владимировна
Published: May 2022

Предмет: в статье рассмотрено влияние ESG-факторов на экономику устойчивого развития РФ в условиях страновых и геополитических рисков в значимых отраслях и формирование новых механизмов корпоративного управления инновациями. Цель: необходимо обосновывать влияние ESG-факторов на управление корпоративными инновациями и привлечение инвестиций в нефтегазовую, электроэнергетическую и банковскую отрасли как основных драйверов экономического роста российской экономики и перехода от линейной к циркулярной модели развития. Проверяется гипотеза об актуальности повестки ESG в сопряжении с целями в области устойчивого развития. Дизайн исследования: для проверки поставленной гипотезы формализовано наполнение исследуемых факторов в рамках ESG-повестки и проведено ранжирование и анализ компаний исследуемых отраслей за 11 периодов, согласно представленным основным элементам ESG-концепции. Результаты: показатели рейтинга марта 2022 г. представили худшие позиции для исследуемых отраслей, что подтверждает активную взаимосвязь с политической ситуацией и изменением страновых рисков, которые также учитываются в рейтинге ESG. Разработаны прогнозы рангов ESG в исследуемых отраслях. Предложены направления снижения рисков для укрепления позиций изученных компаний за счет внедрения корпоративных инноваций с целью увеличения инвестиционной привлекательности в условиях текущей геополитической ситуации.
[RETRACTED] Pure Calms High Grade CBD Gummies - #1 Pain & Stress Relief Supplement v1
Authors: H Philipp
Published: May 2022

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Feeding time is an important part of your dog's day so regularity is a necessary component in his or her overall feeling of well-being.
[RETRACTED] Titan XL Male Enhancement - Restore Muscle & Bedroom Performance? v1
Authors: Douglas Morris H
Published: May 2022

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Dogs will eat for a number of reasons, including boredom. Boredom plus unregulated access to food typically leads to undesirable consequences.