bluuebunny/crossref_metadata_2025 huggingface dataset:
Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer
Authors: Lei Ruilin , Long Yun , Li Qingjian , Xie Qingsheng , Ling Xiaoting , Xie Meiqing , Zhou Hui , Zhang Bingzhong
Published: July 2024

Background

Cisplatin is integral to ovarian cancer treatment, yet resistance to this drug often results in adverse patient outcomes. The association of circular RNA (circRNA) with cisplatin resistance in ovarian cancer has been observed, but the mechanisms governing this relationship require further elucidation.

Methods

High-throughput sequencing was utilized to profile circRNA expression in cisplatin-resistant ovarian cancer cells. Gain-and-loss-of-function experiments assessed the impact on cisplatin sensitivity, both in vitro and in vivo. Fluorescence in situ hybridization was conducted to determine the cellular distribution of circRNAs, and RNA pulldown and immunoprecipitation experiments were performed to identify associated binding proteins.

Results

The study revealed that circ_ARHGEF28 is overexpressed in certain cisplatin-resistant ovarian cancer tissues and cell lines, and is associated with reduced progression-free survival in patients. It was observed that circ_ARHGEF28 contributes to cisplatin resistance in ovarian cancer models, both in vitro and in vivo. Importantly, circ_ARHGEF28 was found to interact directly with MST1/2, inhibiting the SARAH coiled-coil binding domains and consequently deactivating the Hippo pathway.

Conclusion

This investigation identifies circ_ARHGEF28 as a novel circRNA that contributes to cisplatin resistance in ovarian cancer by suppressing the Hippo pathway. Therapeutic strategies targeting circ_ARHGEF28 may offer a potential avenue to mitigate cisplatin resistance in ovarian cancer treatment.
Evidence on sulfadoxine-pyrimethamine resistance molecular markers from India: interpret with caution
Authors: Deora Nimita , Sinha Abhinav
Published: July 2024

Background

Sulfadoxine-pyrimethamine (SP), as a partner to artesunate as ACT is the treatment of choice for uncomplicated P. falciparum infections in the majority of India and SP-resistance has a potential to lead to ACT failure. In the lack of robust surveillance of therapeutic efficacy of SP, validate molecular markers of SP-resistance offer a hint of failing SP. However, studies reporting these validated markers often suffer from certain pitfalls that warrant a careful interpretation.

Main body

Critical analyses of the results and their reported interpretations from a recent study and other studies conducted on the WHO-validated molecular markers of SP-resistance in India were analysed and the main problems with studying and reporting of these markers are presented here. It was noted that almost all studies analysed flawed either on the usage, estimation and/or interpretation of the standardized classification of the studies SP mutations. These flaws not only impart spatiotemporal incomparability of the published data but also have the potential of being misunderstood and wrongly translated.

Conclusion

Based on this universal problem in studying, reporting and interpreting the data from the studies on molecular markers of SP-resistance, it is stressed that the future studies should be conducted with utmost caution so that robust evidence may be generated and correctly translated to policy.
Validation of a digital food frequency questionnaire for the Northern Sweden Diet Database
Authors: Wennberg Maria , Kastenbom Lisa , Eriksson Linda , Winkvist Anna , Johansson Ingegerd
Published: July 2024

Background

Dietary habits strongly influence health, with poor diets contributing to numerous deaths annually. Addressing this requires improved dietary habits and consistent monitoring thereof. In northern Sweden, a validated food frequency questionnaire (FFQ) has been used for decades, but trends show that its ability to accurately measure intake has diminished. With changing eating habits and food supply, updating the FFQ was crucial, leading to the development of FFQ2020. This study assessed FFQ2020’s relative validity using 24-hour recalls and evaluated its reproducibility.

Methods

Participants were recruited from one of the northern-Sweden population-based health screenings and by advertising. Food intake was registered in an electronic food frequency questionnaire (FFQ2020) (test instrument) and reference data were obtained by six repeated electronic 24-hour dietary recalls (24HDR). Intakes of single foods were aggregated into food groups and healthy diet index scores, and daily energy and nutrient intakes were estimated. Results from the two methods were described and tested in univariate analyses and correlation tests, Bland Altman plots, cross-classification validity, and intra-class correlation analyses.

Results

Totally, 628 adults were invited to participate in the study. Of these, 320 joined, and 244 completed at least four 24HDRs. The median intakes in food groups, as well as the mean index scores and estimated nutrient intakes, were largely similar between the FFQ2020 and 24HDR recordings. The correlation coefficients between the two assessments ranged from 0.253 to 0.693 for food groups, 0.520 to 0.614 for diet indices, and 0.340 to 0.629 for energy and nutrients. Intra-class correlation coefficients indicated at least good reproducibility for intakes of food groups, diet index scores, and nutrients. Generally, Bland-Altman plots did not reveal any gross systematic disagreement between the two methods for any of the assessments. However, there were single observations located outside the upper or lower 95% confidence interval (CI) limits for the difference between FFQ2020 and the 24HDR recordings.

Conclusion

In concert, the results suggest that the relative validity and reproducibility of FFQ2020 are acceptable for trend analyses and group comparisons in large-scale studies but also that extended reference periods would improve the precision of less frequently consumed foods.
PEDF-34 attenuates neurological deficit and suppresses astrocyte-dependent neuroinflammation by modulating astrocyte polarization via 67LR/JNK/STAT1 signaling pathway after subarachnoid hemorrhage in rats
Authors: Wu Lei , Liu Yanchao , He Qiuguang , Ao Guangnan , Xu Ningbo , He Wangqing , Liu Xiao , Huang Lei , Yu Qian , Kanamaru Hideki , Dong Siyuan , Zhu Shiyi , Yuan Ye , Han Mingyang , Ling Yeping , Liu Lu , Wu Chenyu , Zhou You , Sherchan Prativa , Flores Jerry J. , Tang Jiping , Chen Xionghui , He Xuying , Zhang John H.
Published: July 2024

Background

Reactive astrocytes participate in various pathophysiology after subarachnoid hemorrhage (SAH), including neuroinflammation, glymphatic–lymphatic system dysfunction, brain edema, BBB disruption, and cell death. Astrocytes transform into two new reactive phenotypes with changed morphology, altered gene expression, and secretion profiles, termed detrimental A1 and beneficial A2. This study investigates the effect of 67LR activation by PEDF-34, a PEDF peptide, on neuroinflammation and astrocyte polarization after the experimental SAH.

Methods

A total of 318 male adult Sprague-Dawley rats were used in experiments in vivo, of which 272 rats were subjected to the endovascular perforation model of SAH and 46 rats underwent sham surgery. 67LR agonist (PEDF-34) was administrated intranasally 1 h after SAH. 67LR-specific inhibitor (NSC-47924) and STAT1 transcriptional activator (2-NP) were injected intracerebroventricularly 48 h before SAH. Short- and long-term neurological tests, brain water content, immunostaining, Nissl staining, western blot, and ELISA assay were performed. In experiments in vitro, primary astrocyte culture with hemoglobin (Hb) stimulation was used to mimic SAH. The expression of the PEDF-34/67LR signaling pathway and neuro-inflammatory cytokines were assessed using Western blot, ELISA, and immunohistochemistry assays both in vivo and in vitro.

Results

Endogenous PEDF and 67LR expressions were significantly reduced at 6 h after SAH. 67LR was expressed in astrocytes and neurons. Intranasal administration of PEDF-34 significantly reduced brain water content, pro-inflammatory cytokines, and short-term and long-term neurological deficits after SAH. The ratio of p-JNK/JNK and p-STAT1/STAT1 and the expression of CFB and C3 (A1 astrocytes marker), significantly decreased after PEDF-34 treatment, along with fewer expression of TNF-α and IL-1β at 24 h after SAH. However, 2-NP (STAT1 transcriptional activator) and NSC-47924 (67LR inhibitor) reversed the protective effects of PEDF-34 in vivo and in vitro by promoting A1 astrocyte polarization with increased inflammatory cytokines.

Conclusion

PEDF-34 activated 67LR, attenuating neuroinflammation and inhibiting astrocyte A1 polarization partly via the JNK/STAT1 pathway, suggesting that PEDF-34 might be a potential treatment for SAH patients.

Graphical Abstract
Verification of Protection Performance of Concrete Blast-Proof Panels Against Internal Explosions
Authors: Park Sangwoo , Kim Kukjoo , Kim Dongku , Park Young-Jun , Shim Byul
Published: July 2024

Recently, studies on blast-proof panels, which were attached to structures to protect facilities from local damage caused by explosions, have been actively performed. However, blast-proof panels are impractical yet due to the high installation cost and difficulty in construction, and protection performance for explosions inside a structure is not evaluated. In this study, a blast-proof panel consisting of concrete material was devised to ensure economic feasibility and constructability. Then, the protection performance of the concrete blast-proof panel for internal explosions was analyzed by numerical simulations and field experiments. First, field experiments on concrete explosion-proof panels were conducted for two cases, where panels without and with energy-absorbing foam were installed. As a result, the concrete blast-proof panel reduced the displacement of structures by up to 22% and the acceleration of structures by up to 86%. However, the reliability of the field experiment data was insufficient due to the shear failure of the test structure during experiments. Therefore, additional analysis was conducted by developing a numerical model. A series of numerical simulations was conducted according to the various densities of the energy-absorbing foam that was inserted between the panel and structure. Consequently, the optimum density of the impact-absorbing material differed depending on the type of structure damage to reduce (i.e., the displacement or acceleration of the structure).
Recycling potato waste for the production of blue pigments by Streptomyces lydicus PM7 through submerged fermentation
Authors: Astudillo Álvaro , Hormazábal Emilio , Quiroz Andrés , Rubilar Olga , Briceño Gabriela , Abdala Roberto , Lamilla Claudio , Diez María Cristina , Schalchli Heidi
Published: July 2024

Background

Discarded potato is the most abundant potato waste and represents a worldwide disposal problem to the potato industry. This agricultural waste contains valuable nutrients that could be used as substrate to obtain diverse high value-added microbial products, such as biopigments. The aim of this work was to evaluate the use of discarded potato as a sole substrate source for producing blue pigments by Streptomyces lydicus PM7 through submerged fermentation.

Results

Initially, the traditional culture medium ISP2 was established as suitable for inoculum preparation, as it allowed high growth rates and consumption of ~ 75% reducing sugar, leading to 1.3 g L−1 dry biomass at 72 h of incubation. The formulated discarded potato broth (DPB) medium was evaluated together with five other traditional liquid culture media (potato dextrose broth, ISP2, ISP3, ISP4, and ISP5) for producing blue pigments by S. lydicus PM7. The highest blue pigment production was obtained by using DPB medium, reaching ~ 0.97 g L−1, followed by ISP5 (~ 0.36 g L−1). In terms of evaluating the concentration of discarded potato powder, the highest concentration of blue pigments was obtained with 16 g L−1, compared to concentrations of 4, 8, and 32 g L−1. In general, a notable increase in total proteins (~ 14 g L−1 in biomass; ~ 8 g L−1 in medium) and reducing sugars (~ 5 g L−1) on the fifth day of DPB fermentation was observed, at which time the production of blue pigments began. These data proved that S. lydicus PM7 is able to degrade potato wastes during submerged fermentation and to direct metabolism towards the formation of biopigments. Chromatographic analysis revealed that the main blue pigment produced by new strain in this complex medium is actinorhodin.

Conclusions

Discarded potato favored the production of blue pigments by S. lydicus PM7 under submerged fermentation, leading to final product concentration almost three times higher than others traditional Streptomyces culture media. To the best of our knowledge, this is the first report on the production of actinorhodin by the specie S. lydicus, as well as on this pigment synthesis based on an agricultural waste as a sole nutrient source for fermentation process. The findings showed that potato waste could be a potential byproduct for replacement of commercial culture media using for this same purpose.

Graphical Abstract
A new strategy for fabricating a stacked flexible capacitive sensor
Authors: Zhu Yuanxiang , Wu Daming , Jiang Haohua , Zhang Weile , Shen Lihao , Sun Jingyao , Zhuang Jian , Xu Hong , Huang Yao
Published: July 2024

Currently, flexible capacitive sensors have a wide range of application scenarios in the field of wearable electronic devices. In order to detect more subtle joint movements of the human body, a method of fabricating stacked capacitive sensors is demonstrated. An ultrathin dielectric elastomer film of about 110 μm by the “secondary calendering” method was prepared. The shape of the electrode layers was designed, printed the electrode materials on the dielectric elastomer film by screen-printing, realized the stacked-layer technology, and connected each sensor unit in parallel by the electrode columns formed inside. A 12-layer flexible capacitive sensor with an initial capacitance of 10.2nF, good resolution (1% strain), high sensitivity (1.09) and stability under 10,000 cycles is fabricated. The sensor fabricated in this paper can recognize the motion at various joints of the human body, such as elbow and knee joints. This paper provides a new method for fabrication of stacked flexible capacitive sensors, which opens up new applications in flexible sensors, wearable electronic devices and human-computer interaction.
Engineering cyanobacteria for the production of aromatic natural products
Authors: Gu Fei , Li Chaofeng , Zheng Haotian , Ni Jun
Published: July 2024

Aromatic natural products are important for improving human health and quality of life. Large-scale availability of these compounds from plants is limited by low yield and cumbersome extraction. Building high-performance microbial cell factories to produce aromatic natural products by means of metabolic engineering and synthetic biology is a viable option. In the context of climate change and global resource scarcity, choosing solar-powered and carbon-fixing microbial cyanobacteria instead of chemical heterotrophic microorganisms to produce aromatic compounds might be a more progressive and better solution. In this review, we summarize the principal strategies for improving the production of aromatic natural products in engineered cyanobacteria, including regulation of metabolism, optimization of synthetic pathway, culture process development, and microbial cooperation, highlighting the potential and availability of this microbe as a novel chassis cell.
A case-history using gravity data to validate alternate interpretations of the material below a deep seismic reflector in the Matheson area of Ontario, Canada
Authors: Della Justina Fabiano , Smith Richard S. , Haugaard Rasmus
Published: July 2024

Gravity data are ‘nonunique’ in that a gravity anomaly can be explained by many bodies with different properties. Similarly, in seismic data, the strength of a reflection is dependent on the product of the density and the seismic velocity, so the nature of a reflection cannot be used to determine the density below an interface when the velocity is unknown. In a previous gravity study, we had concentrated on shallow features (model α), which implicitly assumed that a number of deeper reflections were due to an anomalous layer, thick enough to cause reflections from its upper and lower surfaces that do not cancel and that the density above and below this thick layer were the same. An alternate possibility is that the material below some of the reflections is lower density material called the Deloro assemblage. In order to test this hypothesized model (model β), we reinterpreted the seismic sections and repeated the gravity study. In order to allow for the deeper low-density material and account for some shallower reflectors having Deloro below, we had to make the Porcupine assemblage, which is shallow and even lower density than the Deloro, thinner in places. We found that the gravity data could be explained with the Deloro assemblage below the reflectors. The top of this hypothesized Deloro assemblage varies from 7.5 km in the east to 3 km in the west of the study area. Both models and are consistent with the gravity and seismic data, but model is also consistent with the Deloro being mapped outcropping to the west of the study area and a strong reflector (a banded iron formation) often being observed at the top of the Deloro. Our case study illustrates that modelling and interpretation should often be revised when new information becomes known.
Feasibility of induced magnetic gradient surveying for seepage detection in earth-filled dams: Insights from synthetic and field studies
Authors: Hu Shuanggui , Wang Feiyan , Tang Jingtian , Lu Guangyin , Jiang Zhihai , Zhu Jiao , Guo Yusong , Guo Shiming
Published: July 2024

Seepage is a common hydrogeologic hazard in engineering. Determining the seepage paths is vital for derisking the instability of embankment structures. With the improvement of the acquisition accuracy of magnetic sensors, the magnetometric resistivity method has become an emerging technology for detecting seepage paths through earth-filled dams. This technique is nondestructive and gives prominent signals. However, the resulting magnetic data have seen ambiguity in fully determining the targets. We develop an induced magnetic gradient surveying approach to monitor seepage paths in earth-filled dams. First, we briefly review the electromagnetic theory for the magnetic gradient tensor based on Maxwell’s equations. To match against the measurements, we present an accurate modeling framework using the third-order finite-element method and a novel compact difference scheme. We verify our approach on semianalytical 1D and 3D models. Systematic modeling studies are then carried out to investigate the spatial distribution characteristics and sensitivities of the induced magnetic gradient to the seepage in typical dam scenarios. In addition, we conduct two field experiments in the Zhongmou experimental base and Xixiayuan Reservoir in Henan Province, China, respectively. The induced magnetic field vector and its gradient components are both acquired. Cross-validation with a priori geologic information shows that the seepage path can be spatially identified by the induced magnetic gradient components [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text], whereas the field components failed to locate the seepage pathways. This successful application indicates that our approach could be a promising solution for seepage path discrimination in earth-filled dams with high resolution.
Musings and Meditations on the Edginess and Hatred of Forgiveness
Authors: Opondo Sam Okoth
Published: July 2024

Heeding Frantz Fanon's thoughts on colonialism and forgiveness alongside his call for us to “turn over a new leaf . . . work out new concepts, and try to set afoot a new man,” this text-mediated meditation on the hatred of forgiveness contends with the question/quest of forgiveness and its relevance to our idea of Africa today. To attend to these ethical questions, the author assembles a textual montage by juxtaposing Wole Soyinka's The Burden of Memory, the Muse of Forgiveness lecture series (1997), with some reflections on for/giving from Nathalie Etoke's Melancholia Africana (2019), Jacques Derrida's deconstruction of forgiveness, and Pumla Gobodo-Madikizela's (2004) attempt to imagine and inhabit a postapartheid South Africa where forgiveness acts as an infinite responsibility to the other. As such, this text-mediated meditation engages the newness, closure, eruption or interruption of violence, and forgiveness characteristic of the African present alongside discourses on African memories of grievances and speculations about the Africa that is yet-to-come.
PUNISHMENT AS A SOCIO-CULTURAL AND SPIRITUAL-MORAL PHENOMENON
Authors: Gorshkova Vera S.
Published: July 2024

Purpose. The article is devoted to the analysis of the phenomenon of punishment as a complex phenomenon of reality, which combines the most important postulates of the development and improvement of personality, society and the state, based on cultural values and norms. It acts as an important regulator of the external and internal components of human behavior in society, bearing moral guidelines – the dignity of personality, humanism, justice, mercy.
Tasks. The author has to identify socio-cultural and spiritual and moral features in the phenomenon of punishment by understanding the value-normative component of society when applying negative sanctions to the violator (mutual transition from social to cultural, the use of the Talion principle and the Golden Rule of Morality).
Methodology. The basis of the presented research is formed by comparative, phenomenological, cultural and philosophical research methods that allow us to reveal the essence and features of the interdisciplinary nature of the phenomenon of punishment in the diversity and multidimensional nature of its underlying values and norms.
Results. The results of the work are that the author comes to the conclusion that the phenomenon of punishment contains spiritual, moral and socio-cultural elements. At the interdisciplinary level, it is possible to address the deep foundations of the external and internal behavioral act of a person manifested in society.
The scope of the results. The results of the study can be applied in the field of socio-political design and forecasting.
SPACES OF ART CULTURE ORGANIZATION CREATED BY WOMEN INTELLECTUALS OF THE 17TH CENTURY
Authors: Trofimova Violetta S.
Published: July 2024

Background. The concepts of cultural space and cultural space were analyzed by A.Ya. Flier, L.P. Repina and others. In Western European culture of the 17th century, the problem of the place and role of a woman creator became more acute. The beginning of the present of women’s creativity originates in those times. Women's intellectual culture is a mental and verbal foundation created by creative women of a specific historical era and a specific country.
The relevance of the study of women's intellectual culture of the 17th century is associated with the revival of the awareness of women creators of the past and the destruction of stereotypes in relation to women's creativity. The article analyzes the aspect of the organization of women's intellectual culture of the 17th century in order to identify the spaces in which women creators created works of art.
Methods. While analyzing cultural institutions, an axiological approach is used with the inclusion of an anthropological component. While analyzing the space of art culture organization, methods such as analysis of the physical characteristics of the space, its internal structure, functions, values, place and role of creators in it and the results of their creative activity are used.
Results. Creative women in the 17th century create their own spaces for the production of artistic cultural objects. Such spaces are monastery, female academy, salon, and Women’s Republic of Letters.
Conclusion. The closed spaces for the organization of women's intellectual culture were monastery and female academy, where works of art were created within the framework of tradition. The open space was the salon, which created favorable conditions for creative innovation. In the space of Women’s Republic of Letters the new principles of upbringing and education were worked out.
The rs4354668 polymorphism in the SLC1A2 gene for the EAAT2 glutamate transporter is associated with an increased risk of harmful drug use – an exploratory study on a university student population
Authors: Dawidowski Bartosz , Olejniczak Barbara , Groblińska Katarzyna , Knapińska Magdalena , Kozicka Urszula , Krasiński Michał , Kułak Anna , Grelecki Grzegorz , Czaplińska Zuzanna , Piotrowska Oliwia , Kościelecka Klaudia , Podwalski Piotr , Michalczyk Anna , Samochowiec Jerzy
Published: July 2024

Cel pracy

Dowody sugerują, że zmniejszone wydzielanie dopaminy w szlakach mezokortykolimbicznych może predysponować do zwiększonej podatności na uzależnienie od substancji psychoaktywnych. Zaproponowano zdefiniowanie takiego zjawiska jako zespołu deficytu nagrody (ang. reward deficiency syndrome, RDS). Badania wskazują, że zmniejszenie stymulującej transmisji glutaminergicznej w układzie dopaminergicznym może stanowić alternatywny fenotyp RDS. Potencjalnym źródłem tego typu nieprawidłowości jest wychwyt zwrotny glutaminianu, który zależy od funkcji transporterów aminokwasów pobudzających (ang. excitatory amino acid transporter, EAAT). Celem zaprezentowanego badania była ocena związku wariantów rs4354668 genu dla EAAT2 z ryzykiem wystąpienia zaburzeń związanych z używaniem substancji psychoaktywnych.

Metoda

Przeanalizowaliśmy materiał genetyczny i dane psychometryczne 125 młodych dorosłych (n = 125) pod kątem wpływu polimorfizmu rs4354668 genu SLC1A2 dla EAAT2 na ryzykowne lub szkodliwe używanie narkotyków (ang. risky or harmful drug use, RHDU). Po analizie eksploracyjnej wykorzystaliśmy modele regresji logistycznej do oceny prawdopodobieństwa wystąpienia RHDU w poszczególnych grupach.

Wyniki

W ostatecznym modelu wariant T/T rs4354668 był istotnie powiązany z niższym prawdopodobieństwem wystąpienia RHDU w porównaniu z wariantem G/G (OR: 0.021; 95% CI: 0.001 – 0.275; p = 0.009). Innymi istotnymi predyktorami RHDU były palenie tytoniu oraz ryzykowne lub szkodliwe picie alkoholu.

Wnioski

Uzyskane wyniki mogą wskazywać na możliwy związek ryzyka szkodliwego używania narkotyków z wariantami polimorfizmu rs4354668 genu SLC1A2 dla EAAT2. Osoby z wariantem T/T tego polimorfizmu wydają się być mniej narażone na rozwój zaburzeń związanych z używaniem narkotyków.
Clinical experience with parenteral trazodone in mood disorders: A literature review
Authors: Crapanzano Calogero , Casolaro Ilaria , Krupa Anna Julia
Published: July 2024

Trazodon jest inhibitorem wychwytu zwrotnego i antagonistą receptorów serotoninowych zarejestrowanym w leczeniu epizodów depresji (major depressive disorder – MDD). Doustne formulacje leku zostały obszernie zbadane i są dostępne w kilku krajach świata, jednak dane przemawiające za stosowaniem postaci pozajelitowej są nieliczne. Nasz przegląd narracyjny podsumowuje charakterystykę farmakologiczną i dane kliniczne dotyczące pozajelitowej postaci trazodonu w zaburzeniach nastroju. Aby wyszukać najważniejsze publikacje skorzystano z baz danych PubMed i Web of Science. Kluczowe dane naukowe pochodzące z czterech badań oceniających skuteczność w MDD wskazują, że trazodon był dobrze tolerowany i skuteczny. W trzech próbach donoszono też o zastosowaniu poza wskazaniami rejestracyjnymi (off-label) w agitacji w przebiegu choroby dwubiegunowej, jednak fakt jednoczesnego stosowania innych leków mógł być czynnikiem zakłócającym i wpłynąć na wyniki. Ograniczona ilość dostępnych danych wskazuje na skuteczność trazodonu w postaci podawanej drogą pozajelitową w MDD i pozwala uznać trazodon jako odpowiedni wybór w przypadku pacjentów w wysokim ryzyku manii związanej ze stosowaną farmakoterapią.
Feed production for sustainable aquaculture: A Bibliometric Network Analysis
Authors: Geremia Eugenio , Grande Umberto , Muscari Tomajoli Maria Teresa , Petito Adriana , Fasciolo Gianluca , Napolitano Gaetana
Published: July 2024

In recent years, aquaculture has played a fundamental role in human nutrition and livestock for the ability to produce different animal and vegetable protein and lipid sources essential for human and animal health. However, the growing increase in aquaculture has led to a greater demand for ingredients composing feed for aquatic organisms, many of which are derived from wild fish making the aquatic feed production an unsustainable process. For this reason, the aquaculture sector has expanded experimentation to search for alternative ingredients to reduce environmental impact.
This study explored the global scientific literature on sustainable aquaculture with particular reference to feeding using VOSviewer software, which allows for generating, visualizing, and exploring maps based on bibliometric network data. The results allowed a comprehensive overview of the scientific literature on sustainable aquaculture through network maps displaying the relationships among keywords, authors, countries, and journals. In detail, this paper highlighted that in the last years, particularly in recent decades, the research widely focused attention on different aspects of the sustainable aquaculture field. The first journal that researched sustainable aquaculture was the Aquaculture Journal, and the leading countries that pursued this type of research were the USA, UK, and China. Concerning the co-occurrence, the top keywords were aquaculture, sustainability, animals, nonhuman, and sustainable development, highlighting a growing interest in research on microalgae, diet, fishmeal, and climate change. The description of the current state of the art in sustainable aquaculture reported in this article highlighted that the combined use of social network analysis and bibliometrics allows exploring the development of research in specific fields of science and lays the foundations for delving into questions that have not yet been sufficiently investigated.
The scientific literature on coralligenous habitat and fishing impacts
Authors: Silva Serena , Grande Umberto , Rendina Francesco , Buonocore Elvira , Guidato Michele , Contegiacomo Monica , Franzese Pier Paolo
Published: July 2024

Among marine habitats, the coralligenous represents one of the most important biodiversity hotspots, also playing an important role in the carbon cycle. Coralligenous is a biogenic habitat of the circalittoral zone formed by calcareous structures built by crustose coralline algae and other assemblages of calcifying organisms. Due to its structural complexity, it is also considered one of the most vulnerable marine habitats, very sensitive to environmental changes, such as climate change, and to other anthropogenic impacts such as fishing activities. Trawling is the most harmful fishing method that is causing the degradation of large areas of coralligenous reef concretions. Small-scale and sport fishing can also cause damage to the most sensitive organisms of the coralligenous habitat that can be damaged or removed by fishing gear, both during the fishing activity and in the case of the involuntary abandonment of stranded or damaged fishing nets, also known as “ghost nets”. In this study, the global scientific literature on coralligenous habitat was explored, with a particular focus on human impacts and fishing activities. The analysis was carried out using the VOSviewer software, generating network maps based on literature data retrieved from the Scopus database. The results show that the scientific literature is mainly concentrated in Italy, proving the important contribution provided by the Italian research on the topic. The results also highlight a research gap in the application of environmental accounting methods to quantify and value natural capital and ecosystem services associated to the coralligenous habitat, and their loss due to human impacts.
On the notion of value. A comparative analysis between economic and biophysical approaches
Authors: Corsi Giulio , Buonocore Elvira , Franzese Pier Paolo
Published: July 2024

The plurality of dimensions and topics covered by the SDGs reflects the need to assess the value of organizations, cities, and societies using a holistic approach that considers different dimensions and criteria. It is much needed to shift towards inter-disciplinary, multi-criteria and integrated perspectives, opening the door to views able to consider different scientific points of view when assessing the most “valuable” pillars in human societies. This need highlights a controversial question: “what do we mean when we refer to a concept so broad such as the one of “value” and its measurement”? The concept of value and welfare have changed throughout the years, also in relation to the historical context and societal structure and needs of the time. But time has not been the only factor in differentiating value theories. While most organically structured definitions of value have originated, as expected, from the developments of the economic discipline, this issue has also been addressed by scientists belonging to the biophysical realm. In this paper, a comparative overview of the main economic and biophysical value theories, developing from very different epistemological backgrounds, is provided. Results suggest the need to foster inter-disciplinary communication on the notion of value, which is an abstract construct at the root of our societies and economies.
Cuscuta campestris Yunck.: An emerging threat to the indigenous flora of Assam, India
Authors: Das Barnali , Nath Namita
Published: July 2024

Cuscuta campestris is a well-known holoparasitic angiosperm of the family Convolvulaceae. This leafless, rootless, achlorophyllous angiospermic parasite rapidly expands through its diverse host range. This species also shows self-parasitism. The study recorded 92 host species; Mikania micrantha and Christella dentata being the most preferred hosts. In this manuscript, the taxonomic description of C. campestris, its host range, the anatomy of infected host parts and the nature of parasitism are described. This parasite can bring great loss in sectors like agriculture or horticulture by affecting the economically important host plants. This invasive neophyte must be controlled as soon as possible.
Impact of Fasting and Dietary Interventions on the Development and Treatment of Non-Hodgkin’s Lymphomas and Other Cancers - a review
Authors: Bilecki Krzysztof , Cuper Paulina , Jastrzębska Ilona , Kozicz Michał Andrzej , Gugulski Hubert , Bado Michał , Nowoświat Patrycja , Goncerz Michał
Published: July 2024

Introduction: The present study investigated the role of fasting and diet in the development and treatment of cancers, with a focus on non-Hodgkin’s lymphomas. Dietary components and regimens have an impact on the risk of development of malignances as well as on the treatment of the disease. Cancerous subtypes react differently to various dietary compounds and regimes. Although not widely used- fasting can be valuable help in cancer treatment. In this article we show how diet modifications and restrictions can affect existing therapies.
Aim of the study: By analyzing current literature, the study aimed to understand how various dietary components and regimens influence cancer risk and treatment efficacy.
Methods: Extensive research was conducted using PubMed and Google Scholar. References from selected articles were included in the analysis.
Results: Consuming high amount of fruits and vegetables, unsaturated fats and supplementing vitamin D can reduce the risk of malignancies, with red meat, dairy products and saturated fats intake increasing it. Fasting affects lipid, glucose, protein and neuroendocrine metabolism in the way that helps the treatment of cancers. It slows down tumor growth, reduces some symptoms and improves the effects of chemotherapy. Exploring this topic further could propagate suitable diets for cancer subtypes as well as popularize fasting, which is not yet a widely known adition to standard anti-cancer treatments.
Sport and type 1 diabetes - a great value but also a challenge. Review of the literature and guidelines
Authors: Błaszczak Karolina , Kruszewski Adrian , Paduszyńska Natalia , Dąbrowska Anna , Przybysz Paulina , Szyszka Monika , Kucharska Maja
Published: July 2024

Introduction: Type 1 diabetes is a disease requiring complex treatment: intensive functional insulin therapy with multiple subcutaneous insulin injections (Multiple daily doses of insulin- MDI) or continuous subcutaneous insulin infusion (CSII) with a personal insulin pump. Type 1 diabetes is a disease with many complications including cardiovascular diseases. A key element in good disease control is adequate patient education. This paper will focus on physical activity and its impact on the course of the disease.
 
Aim of the study: To research the impact of physical activity on the course of type 1 diabetes. To reinforce medical professionals' knowledge of exercise management among patients with type 1 diabetes.
 
State of Knowledge: Regular physical exercise is beneficial for diabetes control, at the same time reducing the need for insulin. It also reduces the risk of dangerous late cardiovascular complications. Meta-analyses have shown a significant effect of physical activity on the reduction of HbA1c, BMI, triglycerides and total cholesterol. Continuous glucose monitoring (CGM) systems are recommended for physically active people with type 1 diabetes. Optimal glycaemia at the start and during sport are: for aerobic exercise 126-180 mg/dl (7-10 mmol/l), for anaerobic exercise 90-180 mg/dl (5-10 mmol/l). The reduction in insulin dose depends on the type of exercise, the length of the exercise, the method of treatment, and the pre-exercise blood glucose level.
 
Conclusion: Physical exercise improves the control of type 1 diabetes and therefore reduces the risk of complications of the disease including cardiovascular diseases. Type 1 diabetes is not a contraindication to both amateur and professional sport. However, many variables need to be considered. Every patient with type 1 diabetes must be properly trained before starting exercise.
From Diagnosis to Lifestyle The Impact of Sports on MODY Diabetes Management
Authors: Gała Kamil , Pilarski Konrad , Kucharski Adam , Makuch Rafał , Chrościcka Alicja , Czajka Andrzej , Lenard Paweł , Michalska Sara , Dewicka Martyna , Wawrzyniak Alicja Maria
Published: July 2024

Introduction and objectives: Diabetes is a group of diseases that is currently estimated to affect approximately 537 million adults worldwide. Diabetes can develop due to many factors, including autoimmunity, genetics and insulin resistance. The presented article will discuss the type of monogenic diabetes - maturity onset diabetes in young. This is a relatively rare form of diabetes, affecting no more than 5% of patients with the disease, but it is important to correctly differentiate it and implement appropriate therapy to prevent the development of complications. In addition, the article discusses a group of antidiabetic drugs - sulfonylurea derivatives, which are widely used in diabetic patients.Review and methods: Review and summary of studies and scientific articles avaliable in open-source format on Google Scholar and PubMed.Abbreviated description of the state of knowledge: The diagnosis of MODY diabetes is more extensive than that of the most common types in the population - type 1 and type 2 diabetes.Individual forms of MODY diabetes differ in the location of the mutation in the genome. As a result, the MODY group is heterogeneous, with individuals differing in the severity of symptoms, the treatment used and the presence of developmental abnormalities affecting various organ systems.Sulfonylurea derivatives are a group of drugs that have been used to treat diabetes since the mid-20th century. Their mechanism of action is to stimulate insulin secretion, so it is necessary to preserve at least some of the function of the beta cells in the pancreatic islets when using them. Summary: A collection of information on MODY diabetes is presented based on a review of research and scientific articles. In addition, the section on sulfonylureas provides an overview of first- and second-generation drugs and compares them. The article also highlights the important role of physical activity in managing diabetes and preventing complications.
Effects of intense exercise on pregnancy - a review of the literature
Authors: Kmiotek Weronika , Oronowicz Radosław , Różańska-Smuszkiewicz Gabriela , Smuszkiewicz-Różański Paweł , Karuś Aleksandra , Jama Grzegorz , Staszczak Paweł , Jaworska Barbara , Ragan Dagmara
Published: July 2024

Introduction and Purpose: We are increasingly seeing new trends on social media regarding intense strength training in pregnant women. How much should women in a physiological pregnancy exercise? The aim of this piece is to trace the guidelines and set a healthy limit for such an important aspect during pregnancy.
Materials and methods: A literature search was conducted using the medical databases PubMed and Google Scholar. Articles were retrieved in English, employing the key words: “strength training”, “activity during pregnancy”, „intensive exercise” and „ physical activity guidelines” appropriate configurations.
Conclusions: The available guidelines and medical literature show that it is worthwhile to regularly practise sport both during and in preparation for pregnancy. In a healthy, physiological pregnancy, there is a wide range of activities to choose from, through which health benefits can be achieved, such as strengthening muscles, improving performance, alleviating pregnancy complaints (constipation, pain, nausea) and improving wellbeing, and much more. However, there are contraindications to certain exercises for specific conditions during pregnancy. You should consult your doctor on a case-by-case basis.
Effects of sleep and insomnia on cardiovascular disease - literature review
Authors: Gmitrzuk Julita , Karasiński Maciej , Malinka Zuzanna , Wiśniewska Katarzyna , Jachymek Anna , Opatowska Martyna , Jakubiec Joanna , Kucharski Tomasz
Published: July 2024

Introduction:
Sleep disorders, including insomnia, obstructive sleep apnea (OSA) and other sleep disorders, are increasingly recognized as important risk factors for cardiovascular diseases such as hypertension and coronary artery disease. This review aims to analyze the current literature on the impact of sleep disorders on cardiovascular health, focusing on the underlying pathophysiological mechanisms and the effectiveness of diagnostic and therapeutic approaches. The results highlight the importance of early diagnosis and treatment of sleep disorders to reduce cardiovascular risk.
Aim of the Study:
The main objective of this study is to review and summarize recent findings on the relationship between sleep disorders and cardiovascular diseases, with a particular focus on hypertension and coronary artery disease. This study aims to elucidate the pathophysiological mechanisms linking these conditions and to evaluate the effectiveness of current diagnostic and therapeutic strategies.
Materials and Methods:
This review was conducted by searching PubMed for articles published in the last ten years (2014-2024) using keywords such as „insomnia”, „obstructive sleep apnea”, „hypertension”, „coronary heart disease”, „polysomnography”.
Conclusions:
The evidence reviewed in this article suggests that sleep disorders are important and independent risk factors for cardiovascular disease. Insomnia, obstructive sleep apnea and other sleep disorders contribute to cardiovascular morbidity through mechanisms such as increased sympathetic activity, systemic inflammation and metabolic dysregulation. Effective diagnosis and treatment of sleep disorders, including the use of CPAP therapy for obstructive sleep apnea and cognitive-behavioral therapy for insomnia, can mitigate these risks and improve cardiovascular outcomes.
The Impact of Diet on Male Fertility
Authors: Serkis Barbara , Bentkowska Zuzanna , Miazga Małgorzata , Celichowska Magdalena , Bogoń Aleksandra , Golemo Jagna , Kałuża Izabela , Szpyra Justyna , Dębińska Julia , Dziuba Gabriela
Published: July 2024

Introduction:
Infertility is a reproductive health issue where the inability to conceive after 12 months of regular unprotected intercourse affects about 8 to 12% of couples of reproductive age. Factors such as diet, lifestyle, and exposure to toxins can negatively impact men's reproductive capacity, including semen parameters and gonadal function. The impact of diet on male fertility, including hormone levels and the process of spermatogenesis, is the subject of intense research.
Aim of the Study:
This study aims to review current scientific research on the impact of diet on male fertility to provide updated knowledge on this topic, essential for preventive and therapeutic actions in this field.
Materials and Methods:
A comprehensive review of scientific and medical literature was conducted using PubMed and Google Scholar databases. The search terms included: impact of diet on male fertility, impact of diet on semen parameters, impact of diet on semen quality, male fertility, diet and male fertility, types of diets and fertility.
Conclusion:
Diet plays a crucial role in male fertility, affecting semen quality. It is recommended to consume meat in moderation, especially organic, and to increase the intake of fish rich in omega-3 while avoiding contaminants. Regular consumption of fruits, vegetables, and grains improves semen parameters, while limiting sweets, sugary drinks, and alcohol, as well as quitting smoking, is beneficial for reproductive health. Men planning fatherhood should also consider reducing cannabis use. Future research should focus on the impact of individual dietary factors on male fertility.
Non-operative methods for the treatment of female stress urinary incontinence
Authors: Wojciechowska Klara , Turek Monika , Skotnicka Joanna , Jaroń Aleksandra , Jastrzębska Katarzyna , Piątkowska Karolina , Błaszczak Karolina , Witkowska Maria , Ślósarz Tymoteusz , Witkowski Maciej
Published: July 2024

Purpose of research: Stress urinary incontinence (SUI) is a common health problem, especially among women which impairs daily functioning. The purpose of this research is to elucidate the pathophysiology of stress urinary incontinence (SUI), describe its diagnostic methods, summarize current treatments in light of recent studies, and outline examples of new potential therapies.
Methods: Databases such as PubMed, Medline, and ResearchGate were searched with particular attention to the current guidelines.
Basic results: The primary treatment of SUI is lifestyle modification, including weight reduction. Pelvic floor muscle training (PFMT) is recommended as first-line therapy, reducing the number of incontinence episodes and improving quality of life.  Additional methods include electrical stimulation or biofeedback. At later stages of treatment, pharmacological therapy is recommended, mainly using vaginal oestrogens and duloxetine.
Conclusions: Non-operative therapies, such as lifestyle modification and PFMT, are effective treatments for SUI. In combination with pharmacotherapy, they significantly improve the quality of life of patients without invasive surgical procedures.