bluuebunny/crossref_metadata_2025 huggingface dataset:
Focus group findings on clinicians’ perceived barriers and facilitators to giving rights information to involuntary psychiatrics patients in British Columbia, Canada
Authors: Cheung Iva W. , Silva Diego S. , Miller Kimberly J. , Michalak Erin E. , Goldsmith Charles H.
Published: December 2021

Background

In British Columbia, Canada, clinicians are responsible for giving information about rights to patients involuntarily hospitalized under the Mental Health Act. But a survey commissioned by the Ministry of Health and an investigation by the BC Office of the Ombudsperson found that patients were not consistently receiving rights information.
Methods

Focus groups were used to probe clinicians’ perceived barriers and facilitators to giving patients rights information. Focus group transcripts were thematically analyzed, and the themes were coded using the Theoretical Domains Framework to identify interventions that could encourage clinicians to consistently give patients complete rights information.
Results

Eighty-one psychiatric clinicians participated. Analysis identified these barriers: (a) clinicians receive inadequate training on the Mental Health Act and rights notification; (b) newly admitted patients might not be receptive to new information; (c) the tool used to communicate rights to patients is inadequate; (d) many patients don’t speak English; (e) clinicians have competing priorities during the admission process; (f) clinicians face pressure from other staff to give incomplete information; (g) the clinical workflow doesn’t facilitate follow-up and accountability; and (h) staff don’t receive enough support from their employer. The following facilitators were identified: (a) a team approach allows clinicians to share knowledge about the Mental Health Act and rights notification, (b) having one person take responsibility for rights information clarifies roles and increases accountability, (c) accreditation reminds clinicians of the importance of giving patients rights information, and (d) checklists remind clinicians of their rights-notification responsibilities.
Conclusions

These interventions may help clinicians give rights information more consistently: (a) training about the Mental Health Act and rights notification, (b) an accessible legal resource for clinicians and patients, (c) regular group sessions about rights for patients, (d) an improved rights-communication tool, in multiple languages, and (e) checklists, reminders, and accountability and feedback systems.
Spin-Thermoelectric Effects in a Quantum Dot Hybrid System With Magnetic Insulator
Authors: Trocha Piotr , Siuda Emil
Published: December 2021

We investigate spin thermoelectric properties of a hybrid system consisting of a single-level quantum dot attached to magnetic insulator and metal electrodes. Magnetic insulator is assumed to be of ferromagnetic type and is a source of magnons, whereas metallic lead is reservoir of electrons. The temperature gradient set between the magnetic insulator and metallic electrodes induces the spin current flowing through the system. The generated spin current of magnonic (electric) type is converted to electric (magnonic) spin current by means of quantum dot. Expanding spin and heat currents flowing through the system, up to linear order, we introduce basic spin thermoelectric coefficients including spin conductance, spin Seebeck and spin Peltier coefficients and heat conductance. We analyse the spin thermoelectric properties of the system in two cases: in the large ondot Coulomb repulsion limit and when these interactions are finite.
Taxonomic Dependency of Beta Diversity for Bacteria, Archaea and Fungi in a Semi-Arid Lake
Authors: Yuan Haijun , Zhang Weizhen , Yin Huaqun , Zhang Runyu , Wang Jianjun
Published: December 2021

Microbial beta diversity has been recently studied along the water depth in aquatic ecosystems, however its turnover and nestedness components remain elusive especially for multiple taxonomic groups. Based on the beta diversity partitioning developed by Baselga and Local Contributions to Beta Diversity (LCBD) partitioning by Legendre, we examined the water-depth variations in beta diversity components of bacteria, archaea and fungi in surface sediments of Hulun Lake, a semi-arid lake in northern China, and further explored the relative importance of environmental drivers underlying their patterns. We found that the relative abundances of Proteobacteria, Chloroflexi, Euryarchaeota and Rozellomycota increased towards deep water, while Acidobacteria, Parvarchaeota and Chytridiomycota decreased. For bacteria and archaea, there were significant (P < 0.05) decreasing water-depth patterns for LCBD and LCBDRepl (i.e., species replacement), while increasing patterns for total beta diversity and turnover, implying that total beta diversity and LCBD were dominated by species turnover or LCBDRepl. Further, bacteria showed a strong correlation with archaea regarding LCBD, total beta diversity and turnover. Such parallel patterns among bacteria and archaea were underpinned by similar ecological processes like environmental selection. Total beta diversity and turnover were largely affected by sediment total nitrogen, while LCBD and LCBDRepl were mainly constrained by water NO2−-N and NO3−-N. For fungal community variation, no significant patterns were observed, which may be due to different drivers like water nitrogen or phosphorus. Taken together, our findings provide compelling evidences for disentangling the underlying mechanisms of community variation in multiple aquatic microbial taxonomic groups.
African-specific prostate cancer molecular taxonomy
Authors: Hayes Vanessa , Jaratlerdsiri Weerachai , Jiang Jue , Gong Tingting , Patrick Sean , Willet Cali , Chew Tracy , Lyons Ruth , Haynes Anne-Maree , Pasqualim Gabriela , Louw Melanie , Kench James , Campbell Raymond , Chan Eva , Wedge David , Sadsad Rosemarie , Brum Ilma , Mutambirwa Shingai , Stricker Phillip , Bornman Riana , Horvath Lisa
Published: December 2021

Prostate cancer is characterised by significant global disparity; mortality rates in Sub-Saharan Africa are double to quadruple those in Eurasia1. Hypothesising unknown interplay between genetic and non-genetic factors, tumour genome profiling envisages contributing mutational processes2,3. Through whole-genome sequencing of treatment-naïve prostate cancer from 183 ethnically/globally distinct patients (African versus European), we generate the largest cancer genomics resource for Sub-Saharan Africa. Identifying ~2 million somatic variants, Africans carried the greatest burden. We describe a new molecular taxonomy using all mutational types and ethno-geographic identifiers, including Asian. Defined as Global Mutational Subtypes (GMS) A–D, although Africans presented within all subtypes, we found GMS-B to be ‘African-specific’ and GMS-D ‘African-predominant’, including Admixed and European Africans. Conversely, Europeans from Australia, Africa and Brazil predominated within ‘mutationally-quiet’ and ethnically/globally ‘universal’ GMS-A, while European Australians shared a higher mutational burden with Africans in GMS-C. GMS predicts clinical outcomes; reconstructing cancer timelines suggests four evolutionary trajectories with different mutation rates (GMS-A, low 0.968/year versus D, highest 1.315/year). Our data suggest both common genetic factors across extant populations and regional environmental factors contributing to carcinogenesis, analogous to gene-environment interaction defined here as a different effect of an environmental surrounding in persons with different ancestries or vice versa. We anticipate GMS acting as a proxy to intrinsic and extrinsic mutational processes in cancers, promoting global inclusion in landmark studies.
Nonlinear suboptimal attitude control law for near-space hypersonic vehicle: Eigenvalue analysis and weight matrices design
Authors: Mi Peichao , Wu Qingxian , Wang Yuhui
Published: December 2021

This paper considers a nonlinear suboptimal control problem for a near-space hypersonic vehicle's (NSHV's) attitude dynamics. The least-square and stable manifold methods first solve an unconstrained approximately optimal control law corresponding to the nonlinear attitude model. Then, to further meet the dynamic performance requirement of the attitude control system, a novel strategy based on the Koopman operator, symplectic geometric theory, and the stable manifold theorem is proposed to approximate the eigenvalues of the closed-loop nonlinear unconstrained approximated optimal control system. The weight matrices in the optimal performance index, which directly determine the output responses of the nonlinear attitude dynamics, can be appropriately designed according to the eigenvalues. The final control law considers the actuator constraints. The NSHV's closed-loop attitude control system is proved to be locally exponentially stable, and the suboptimality of the control law is analyzed. Numerical simulation demonstrates the effectiveness of the proposed scheme.
Equilibrium Optimizer with Generalized Opposition-based Learning for Multiple Unmanned Aerial Vehicles Path Planning
Authors: Chen Yang , Pi Dechang , Wang Bi , Mohamed Ali Wagdy , Chen Junfu
Published: December 2021

Multiple Unmanned Aerial Vehicles (UAVs) path planning is the benchmark problem of multiple UAVs application, which belongs to the non-deterministic polynomial problem. Its objective is to require multiple UAVs flying safely to the goal position according to their specific start position in three-dimensional space. This issue can be defined as a high-dimensional optimization problem, the solution of which requires optimization techniques with global optimization capabilities. Equilibrium optimizer (EO) is a population-based meta-heuristic algorithm. In order to improve the optimization ability of EO to solve high dimensional problems, this paper proposes a modified equilibrium optimizer with generalized opposition-based learning (MGOEO), which improves the population activity by increasing the internal mutation and cross of the population. In addition, the generalized opposition-based learning is used to construct the population, which can effectively ensure that the algorithm has ability to jump out of the limitation of local optimal. Firstly, numerical experiments show that MGOEO has better optimization precision than EO and several other swarm intelligent algorithms. Then, the paths of UAVs are simulated in three different obstacle environments. The simulation results show that MGOEO can obtain safe and smooth paths, which are better than EO and other eight state-of-the-art optimization algorithms.
Exosomal tRF-Leu-AAG-001 Derived from Mast Cell as a Potential Non-Invasive Diagnostic Biomarker for Endometriosis
Authors: Li Yingxue , Cui Shuling , Xu Zemin , Zhang Yanping , Wu Tao , Zhang Jing , Chen Yichen
Published: December 2021

Background: The diagnosis of endometriosis (EMs) is still based on laparoscopic observation. This study tries to verify whether exosomal tRNA-derived fragments (tRFs) in leucorrhea can be used as non-invasive diagnostic markers.Methods: Endometrial tissues and leucorrhea were sampled from women hospitalized in Ningbo University Affiliated Hospital from January 2021 to July 2021 with (n=26) and without endometriosis (n=25). Exosomes were isolated from samples by differential centrifugation. The small RNA sequencing was performed to detect the exosomal tRNA halves (tiRNAs)&tRFs. RNA probe and immunofluorescence antibody were used to localize the origin of tRFs. From mast cell lines infected with tRF-Leu-AAG-001 siRNA, we observed the change in vascular capacity and expression of inflammatory factors. The specificity and sensitivity tRF were determined by receiver operating characteristic analyses.Results: 63 up-regulated and 45 down-regulated tRFs&tiRNAs were identified in ectopic exosomes. We selected tRF-Leu-AAG-001 as a candidate marker through KEGG pathway enrichment and PCR verification. We found that mast cells highly expressed tRF-Leu-AAG-001 in ectopic foci by immunofluorescence staining. We used siRNA to silenced tRF-Leu-AAG-001 expression in luva, qPCR analysis showed IL-6, IL-10, IL-1β, and TNF-α were significantly decreased. Meanwhile, tRF-Leu-AAG-001 siRNA dramatically reduced the angiogenic ability of luva. Finally, we examined the expression of exosomal tRF-Leu-AAG-001 in the leucorrhea. It was found exosomal tRF-Leu-AAG-001 had high specificity and sensitivity for predicting the occurrence of ectopic disease. Conclusions: Exosomal tRF-Leu-AAG-001 derived from mast cells in ectopic foci might promote inflammation and angiogenesis. Meanwhile，leucorrhea exosomal tRF-Leu-AAG-001 could be a potential diagnostic biomarker for endometriosis.
Effect of Time Restricted Feeding on Anthropometric Measures, Body Composition, Eating Behavior, Stress, Brain Derived Neurotrophic Factor (BDNF) and Lipopolysaccharide Binding Protein (LBP) Levels in Food Addicted Over Weight and Obese Women: A Study Protocol for a RRandomized Clinical Trial
Authors: Irani Hanieh , Khodami Banafsheh , Abiri Behnaz , Saidpour Atoosa
Published: December 2021

Background: Food addiction, the desire to eat compulsively and excessively palatable foods, is one of the behavioral factors that plays an important role in pathogenesis of obesity. Food addiction, like drug addiction, changes the dopaminergic system in rewards region of brain, but at lower levels. There are evidence suggesting brain-derived neurotrophic factor (BDNF) is synthesized in dopaminergic pathways in the reward regions of the brain and is involved in regulating food intake and body weight. BDNF is also associated with eating disorders in humans and hyperphagia in mice. On the other hand, it has been shown that the intestinal microbiome is effective in eating behavior through the production of neuronal and hormonal mediators, including BDNF. Intestinal microbiome changes greatly under the influence of diet. It has been shown that a time-restricted feeding (TRF) has been able to maintain fluctuations in the intestinal microbiome in response to the body's circadian rhythm. Furthermore, increased pathogens in the gut are associated with increased release of polysaccharides from the bacterial wall, resulting in increased levels of lipopolysaccharide binding protein (LBP). This study will aim to evaluate the effect of TRF on anthropometric measures, body composition, eating behavior, stress level, BDNF and LBP levels in over weight and obese women with food addiction.Methods/design: we will carry on a randomized clinical trial for 8 weeks to evaluate the effect of a TRF on anthropometric measures, body composition, eating behavior, stress level, BDNF and LBP levels in obese and overweight women with food addiction.Discussion: Given the effect of BDNF on regulating eating behavior and body weight and the effect of dietary restrictions on BDNF and the gut microbiome, the TRF diet could possibly be a new way to successfully manage weight through modifying BDNF in people with eating disorders, including food addiction.Trial Registration: Iranian Registry of Clinical Trials. IRCT20131228015968N7. Registered on 2020-10-25.
Spatiotemporal Parameters And Gait Variability In People With Psoriatic Arthritis (Psa) : A Cross-Sectional Study.
Authors: Walha Roua , Gaudreault Nathaly , Dagenais Pierre , Boissy Patrick
Published: December 2021

Background: Foot involvement is a major manifestation of psoriatic arthritis (PsA) and could lead to severe levels of foot pain and disability and impaired functional mobility and quality of life. Gait spatiotemporal parameters (STPs) and gait variability, used as a clinical index of gait stability, have been associated with several adverse health outcomes including risk of falling, functional decline, and mortality in a wide range of populations. Previous studies showed some alterations in STPs in people with PsA. However, gait variability and the relationships between STPs, gait variability and self-reported foot pain and disability have never been studied in this populations. Body-worn inertial measurement units (IMUs) are gaining interest in measuring gait parameters in clinical settings.Objectives: To assess STPs and gait variability in people with PsA using IMUs and, to explore their relationship with self-reported foot pain and function and to investigate the feasibility of using IMUs to discriminate patient groups based on gait speed-critical values.Methods: 21 participants with PsA (Age: 53.9 ± 8.9 yrs; median disease duration: 6 yrs) and 21 age and gender-matched healthy participants (Age 54.23 ± 9.3 yrs) were recruited. All the participants performed three 10-meter walk test trials at their comfortable speed. STPs and gait variability were recorded and calculated using six body-worn IMUs and the Mobility Lab software (APDM®). Foot pain and disability were assessed in participants with PsA using the foot function index (FFI).Results: Cadence, gait speed, stride length, and swing phase, were significantly lower, while double support was significantly higher, in the PsA group (p< 0.006). Strong correlations between STPs and the FFI total score were demonstrated (|r|> 0.57, p< 0.006). Gait variability was significantly increased in the PsA group, but it was not correlated with foot pain and function (p< 0.006). Using the IMUs three subgroups of participants with PsA with clinically meaningful differences in self-reported foot pain and disability were discriminated.Conclusion: STPs were significantly altered in participants with PsA which could be associated with self-reported foot pain and disability. Future studies are required to confirm the increased gait variability highlighted in this study and its potential underlying causes. Using IMUs in clinical settings has been useful to objectively assess foot function in people with PsA. Study registration: ClinicalTrials.gov, NCT05075343, Retrospectively registered on 29 September 2021.
Tailoring Research Evidence and Theory (TREAT) into Allied Health Journal Clubs: A Hybrid Effectiveness-Implementation Study
Authors: Wenke Rachel , Wiseman Jodie , Brandenburg Caitlin , Stehlik Paulina , Hughes Ian , Richards Katherine , Mickan Sharon
Published: December 2021

BackgroundAllied Health Professionals (AHPs) commonly use journal clubs (JCs) to support Evidence-Based Practice (EBP). There is however little research regarding implementing JCs in the long term, and their impact on EBP use and skills in AHPs. This study investigated the impact of implementing a structured JC format, called “TREAT” that was specifically tailored for each club, on EBP skills, confidence, use and resultant changes in clinical practice over 16 sessions for AHPs in a public health service. The study also investigated AHP’s attendance, adherence, satisfaction and barriers and enablers to implementing the format.MethodsA mixed methods hybrid-effectiveness implementation design was employed, guided by the Knowledge-to-Action cycle. EBP skills, confidence, use, and attitudes were assessed (Adapted Fresno Test, EBPQ, tailored journal club culture questionnaire) at baseline, and after 10 and 16-monthly JC sessions. Satisfaction and impact on clinical practice were explored using questionnaires at the latter two time-points, with free-form responses identifying enablers and barriers to EBP culture and implementation. Data on attendance and adherence to the TREAT format were also collected. ResultsSix JCs comprising a total of 132 unique participants from seven Allied Health professions were assessed across three time points. EBP skills significantly improved on the Adapted Fresno Test after 10-monthly (6.6 points: 95% CI, 0.43 to 12.7) and 16-monthly sessions (7.8 points, 95% CI, 0.85 to 14.7), and on self-reported total EBPQ ratings of confidence at 10-months (4.9 points: 95% CI, 2.2 to 7.5) and 16-months (5.7 points: 95% CI 2.7 to 8.7). Across sessions, 88 AHPs reported adopting new treatments/resources and 64 AHPs reported updating clinical procedures. Mean attendance was 5.7 sessions (SD= 3.8), and average adherence to TREAT components each session was 86% (95% CI, 83 to 89). Most participants recommended the format and reported desire to continue TREAT JCs. Enablers to the JC included using clinically relevant topics and active participation, while reported barriers included limited time to prepare. ConclusionsTREAT JCs can be implemented and sustained by AHPs for 16 monthly-sessions. Participation improved EBP skills and confidence and led to changes in clinical practice. Contextual enablers and barriers should be considered when implementing locally.
Prediction And Verification of Wafer Surface Morphology in Ultrasonic Vibration Assisted Wire Saw (UAWS) Slicing Single Crystal Silicon Based On Mixed Material Removal Mode
Authors: Wang Yan , Wang Rui , Li Shusheng , Liu Jianguo , Song Lixing
Published: December 2021

Monocrystalline silicon is one of the most important semiconductor materials, widely used in chip manufacturing, solar panels. Slicing is the first step in making chips and the surface quality of silicon wafers directly affects the quality of later processing and accounts for a large proportion in the chip manufacturing cost. Ultrasonic vibration assisted wire saw (UAWS) is an effective sawing process for cutting hard and brittle materials such as monocrystalline Si, which can significantly improve the surface quality of silicon wafers. In order to further study the formation mechanism of the surface morphology of single crystal silicon sliced by UAWS, a new model for prediction of wafer surface morphology in UAWS slicing single crystal silicon based on mixed material removal mode is presented and verified in this paper. Firstly, the surface model of diamond wire saw tool is established by equal probability method. Then according to the equation of transverse vibration dynamics about the wire saw with ultrasonic excitation, the trajectory equation of arbitrary abrasive particles on the surface of wire saw is derived and analyzed. Thirdly, a new model for prediction of the wafer surface morphology based on mixed material removal mode is presented, which can be used to predict the wafer surface morphology of single crystal silicon sliced by UAWS. Finally, the prediction model is verified by UAWS slicing experiment, and the effects of slicing parameters such as wire saw speed, feed speed and workpiece rotate speed on the surface quality of silicon wafer were studied. It shows that the predicted wafer surface morphology and the experimental wafer surface morphology are similar in some characteristics, and the average error between the experimental and the theoretical values of the wafer surface roughness is 11.9%, which verifies the validity of the prediction model.
Identifikasi Keragaman Penyediaan Sarana Prasarana pada Perumahan Peri-Urban Kabupaten Sleman
Authors: Utari Sekar Ari , Nareswari Ardhya
Published: December 2021

Title: Diversity Identification of Infrastructure Provision in Peri-Urban Housing Sleman Regency

 

The procurement of housing infrastructure has been regulated through SNI 03-1733-2004. However, in the field, developers have their own considerations and creativity in providing them. The diversity of provision raises the problem of equal public access to infrastructure. This study aims to identify the diversity of housing infrastructure provision in Sleman Regency. The research used deductive-qualitative method. The analysis was carried out through the stages of data grouping, housing type analysis, analysis of infrastructure availability and comparative analysis. The results showed different provision between small-scale and medium-scale housing. Basic infrastructure is the top priority and security infrastructure is the second priority. Variations are found in amenities and health facilities and the least provided are religious and educational facilities.
Glycemia under control
Authors: Kalinina Nadezhda
Published: December 2021

Diabetes mellitus (DM) has become a global and national menace. The number of patients with diabetes in the Russian Federation tallied roughly 5.1 million, according to the incidence of outpatient visits in 2020 [1]. “Do-it-yourself” regular measurements of blood glucose levels (self-monitoring) are one of the most important components in achieving the therapy goals for patients with diabetes and preventing severe vascular complications. Now that the technologies have caught on, new “smart” glucometers appeared, which enable remote control and significantly expand opportunities of DM monitoring due to free mobile application integration.
Etiological aspects of chronic pathology of the lymphepithelial pharyngeal ring in children at the present stage
Authors: Preobrazhenskaya Yu. S. , Drozdova M. V. , Ryazantsev S. V.
Published: December 2021

The lymphoepithelial pharyngeal ring is located in the entrance gate and is constantly exposed to infectious agents. Currently, chronic pathology of the lymphoepithelial pharyngeal ring remains one of the most common problems in the practice of a pediatric doctor. Hypertrophy of the pharyngeal tonsil, chronic adenoiditis, which occurs in 35.3% of children under the age of 7 years, and chronic tonsillitis, which occurs in 15-63% of cases, are among the most common diseases of childhood. Taking into account the wide range of infectious microbiota that contributes to the development of chronic pathology of the lymphoepithelial pharyngeal ring, the issue of differential diagnosis of the etiology of the disease and the selection of adequate treatment regimens remains relevant. In most cases, at the present stage, the approach to the treatment of patients with chronic inflammation of the lymphoid ring of the pharynx in children is reduced to replacing the surgical method with a conservative one with the appointment of immunocorrective and immunomodulatory drugs. The lack of a positive effect of the ongoing conservative treatment, clinical and laboratory signs of persistent streptococcal infection say us about the need for surgical treatment. At the same time, a group of frequently ill children requires special attention with the development of new regimens of the immunocorrecting and immunomodulating drugs usage.
New opportunities in the allergic rhinitis therapy
Authors: Pavlova K. S. , Mdinaradze D. S.
Published: December 2021

Allergic rhinitis (AR) is one of the most common allergic diseases, especially in economically developed countries, including Russia. The main goal of AR therapy is the control achievement over the disease symptoms, the minimizing of the future exacerbations risks and side effects. Antihistamines and glucocorticosteroids are the main classes of medicines used in all allergic diseases, including AR. According to the Federal Clinical Guidelines for Allergic rhinitis the use of the intranasal corticosteroids in combination with antihistamines is recommended on the second stage of therapy and higher. Both classes of medicines have a complementary effect on the allergic inflammation pathogenesis main stages. The intranasal corticosteroids and antihistamines using allows the delivery of the medicines to the allergic inflammation area directly. Modern intranasal corticosteroids have a high affinity that provides the high efficacy in the low concentrations using and the insignificant systemic bioavailability. The review presents the key characteristics of the olopatadine and mometasone furoate nasal spray in a fixed combination, which registered in the Russian Federation recently. This combination is recommend for use in adults and children over 12 y.o. with allergic rhinitis. The pharmacological characteristics of the nasal spray components including the action mechanism described. The main clinical studies results presented, that confirmed the high efficacy and safety of olopatadine/mometasone furoate combination in AR patients. The olopatadine and mometasone furoate fixed combination ensures the rapid onset and the long-lasting effect with minimal adverse events risks that increases compliance and leads to the control achievement over the AR symptoms.
Modern possibilities of herbal medicine in the treatment of acute inflammatory diseases of the upper respiratory tract
Authors: Gurov A. V. , Muzhichkova A. V.
Published: December 2021

The article provides data on the effectiveness of the use of the drug in the treatment of acute, chronic and recurrent diseases of the respiratory tract and ENT organs. The drug is an extract of Pelargonium sidoides. From the standpoint of modern pharmacology, it is known that the use of natural products based on plant materials ensures safety and the absence of pronounced side effects. The main active ingredients of pelargonium are phenolic compounds: coumarins, flavonoids and phenolic acids. The article details the biochemical and pharmacological properties of each of the above groups of compounds. It has been shown that the presence of several classes of phenolic compounds simultaneously contributes to the potentiation of the pharmacological effects of each group separately. Therefore, drug has a pronounced polytropic effect: antiviral, antibacterial, immunomodulatory, mucolytic, anti-inflammatory, antioxidant, cytoprotective. The article presents the results of numerous domestic and foreign randomized, placebo-controlled studies demonstrating its high efficacy and safety in the treatment of ENT diseases, upper respiratory tract infections and bronchitis, not only in adults, but also in children over 1 year old. On the basis of the analyzed and presented material, the authors concluded that the use of a natural-based drug in the treatment of acute respiratory infection is effective and safe, both as monotherapy and in combination with other medicinal substances. He is able to quickly eliminate not only the symptoms of inflammation, but also to support the body with any ailments of this type.
Temporomandibular Disorder and Cerebellopontine Angle Meningioma: Perspectives from Three Medical Specialists
Authors: Klyachko D. S. , Bystrova Yu. A. , Bystrov S. A. , Ryazantsev S. V. , Partyushko V. V. , Donskaya O. S. , Margiev A. D. , Zaytsev E. A.
Published: December 2021

Introduction. The relevance of the study is due to the complexity of the differential diagnosis of Kosten's syndrome and meningioma in the area of the cerebellar bridge angle of the brain, as well as the severe suffering of patients

The purpose of our study: development of an algorithm for the approach to the differential diagnosis of meningioma of the cerebellar angle and Kosten's syndrome.

Materials and methods. To accomplish the set tasks, we examined 22 patients who complained of headache, hearing impairment, sensation of tinnitus, pain and crepitus in the temporomandibular joint during movements of the lower jaw, paresthesia of the oral and nasal mucosa. All patients were assigned studies: cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) of the TMJ according to indications.

Results. Since complaints can lead patients to see doctors of various specialties, it is necessary to be able to differentiate between Costen's syndrome and a tumor of the cerebral pons-cerebral angle. In Costen's syndrome, the pain most often has an aching character, in contrast to the volumetric formations of the brain, in which the pain is burning, spreading along the branches of the facial or trigeminal nerve. One of the main methods of excluding a brain tumor is magnetic resonance imaging.

Conclusions. The most significant modern method for diagnosing Costen's syndrome and meningioma of the cerebellopontine angle is magnetic resonance imaging (MRI) of the TMJ and the brain. Differential signs of Costen's syndrome are distal displacement of the head of the lower jaw, diagnosed by CBCT and MRI, as well as displacement of the articular disc (determined by MRI). A meningioma of the cerebellopontine angle is indicated by the burning nature of pain in half of the face, as well as confirmation of the diagnosis by magnetic resonance imaging of the brain.
Local and systemic oxidative stress in chronic suppurative otitis media
Authors: Dubinets I. D. , Korkmazov M. Yu. , Sinitskii A. I. , Danshova E. I. , Skirpichnikov I. N. , Mokina M. V. , Mirzagaliev D. M.
Published: December 2021

Introduction. According to the literature, oxidative stress is described as one of the main factors in the pathogenesis of chronic suppurative otitis media, supporting the inflammatory process at the local level. The transition of inflammatory mediators to the systemic level is associated with the risk of developing ear purulent-destructive complications. The study of the products of lipid peroxidation in comparison with morphological changes in the structures of the temporal bone will justify the tactics of the operation.

Aim. Comparison of the levels of lipid peroxidation products at the local and systemic levels in chronic suppurative otitis media, depending on the nature of pathomorphological changes in the structures of the temporal bone.

Materials and methods. A prospective study of 130 patients with chronic suppurative otitis media at the age of 20-62 years with a verified diagnosis of chronic suppurative otitis media, admitted for surgical treatment, was carried out. To study the indicators of oxidative stress at the systemic level, the blood serum of patients was used; at the local level, the bone biomaterial obtained from patients during the surgical treatment of chronic suppurative otitis media was used. The quantitative determination of the primary, secondary and final products of peroxidation was carried out in the groups of patients with separate registration of lipoperoxides in the heptane and isopropanol phases of the lipid extract by spectrophotometry.

Results and discussion. In the observation of patients with morphological signs of purulent destruction of the temporal bone, not only a local level of inflammation activity, but also a systemic level of an unfavorable outcome was revealed in two variants: osteoproliferation or osteonecrosis of the bone tissue of the temporal bone in chronic purulent otitis media with a constant threat to the patient's life due to intracranial purulent complications.

Conclusion. The appearance in low concentrations of lipid peroxidation products in serum in patients with chronic purulent otitis media substantiates the need for a behind-the-ear approach in reconstructive-sanitizing otosurgery even with minimal clinical manifestations and CT scan data, since at the preclinical level it confirms the osteonecrotic type of bone remodeling with the risk of delayed death.
Endolaryngeal surgery of benign vocal fold lesions with a 445 nm semiconductor laser: postoperative management
Authors: Krivopalov A. A. , Shamkina P. A. , Stepanova Ju. E. , Koren E. E. , Gotovyakhina T. V.
Published: December 2021

Introduction. Today the high prevalence of benign vocal fold lesions is shown (up to 55-70%). The possibilities of surgical management of this pathology are very extensive. Laser technologies are becoming more and more popular among high-tech treatment methods. However the comprehensive postoperative management of these patients is equally important.

The aim of the study was to assess the features of the postoperative period in patients undergoing the endolaryngeal surgery using a semiconductor laser with a wavelength of 445 nm.

Material and methods. On the basis of Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech from February to June 2021 20 patients with benign vocal fold lesions 6 women and 14 men from 24 to 67 years old were examined and treated. All the patients underwent endolaryngeal surgery with direct microlaryngoscopy using a new semiconductor 445 nm laser in an inert gas atmosphere (intraoperative helium supply). After surgical treatment, the patients observed vocal rest, received antiinflammatory, antibacterial therapy, inhalations, as well as the drug Homeovox® according to the standard scheme.

Conclusion. Endolaryngeal surgery with the removing of benign vocal fold lesions using a semiconductor laser with a wavelength of 445 nm has been proven to be safe and effective. According to the results of video laryngostroboscopy, acoustic analysis of the voice (the questionnaire “Voice handicap index-30”) it was noted that the laryngeal functions were restored in a short time. The inclusion of Homeovox® in the complex postoperative treatment had a favorable effect on the restoration of the phonatory function.
Prospects for using herbal preparation in combination with physical methods in complex therapy of chronic adenoiditis
Authors: Korkmazov M. Yu. , Solodovnik A. V. , Korkmazov A. M. , Lengina M. A.
Published: December 2021

Introduction. Importance of the search effective methods of treating chronic adenoiditis in children is associated with a high incidence and risk of developing complications. Treatment of chronic adenoiditis are described in the literature, but the advantages of any of them are inconclusive, which leads to the search for additional more progressive methods.

Objective. To increase the effectiveness of the treatment of chronic adenoiditis using complex therapy of non-drug methods in combination with the herbal preparation Tonsilgon N.

Materials and methods. Biochemical changes in lymphoid tissue were studied on biopsy material in 111 children with chronic adenoiditis, grade 3 adenoid hypertrophy, directed to planned surgical treatment. In the preoperative period, patients were divided into 4 groups: Group 1-control group, patients who received conventional methods of treatment; 2-study group, patients who additionally used low-frequency ultrasound irrigation of the nasal cavity and nasopharynx with photochromotherapy; The third group, patients who received the herbal preparation tonsilgon N (drops) as preoperative therapy; The fourth group study underwent low-frequency ultrasound irrigation of the nasal cavity and nasopharynx in combination with photochromotherapy and took the drug Tonsilgon N in an age-related dosage.

Results and discussion. When comparing the results of biochemical studies, an increase in the products of lipid peroxidation was noted in patients of the first group, which was regarded as a factor in the protracted course of the disease. The use of targeted phytoniring drugs in combination with low-frequency ultrasonic cavitation and photochromotherapy in complex therapy significantly modulates the processes of lipid peroxidation and can potentiate the antioxidant protection of cells.

Conclusion. Objective data were obtained for the first time on biochemical changes in lymphoid tissue for various methods of therapy indicate the prospects of using non-drug methods in combination with a herbal preparation in the complex therapy of chronic adenoiditis.
Results of the study of conservative treatment of laryngeal manifestations of laryngopharyngeal reflux
Authors: Angotoeva I. B. , Magomedova M. M.
Published: December 2021

Gastroesophageal reflux disease (GERD) is a disease of the gastrointestinal tract caused by the discharge of stomach contents into the esophagus. In GERD, both esophageal and extraesophageal manifestations are widespread, but, unfortunately, the latter are less well known. About one third of GERD patients have extraesophageal symptoms, which can occur even in the absence of the usual esophageal symptoms of GERD, which makes diagnosis difficult. The most common of these is laryngitis. In addition to reflux laryngitis, laryngopharyngeal reflux (LFR) can cause the development of contact granulomas, laryngeal stenosis, functional dysphonia, vocal fold nodules, Reinecke's edema, and laryngeal neoplasms. These symptoms disappear after taking antireflux therapy, but there is still no consensus on its duration.

Aim. To evaluate the results of treatment of laryngeal manifestations of LFR with omeprasole 20 mg 30 minutes before meals in the morning.

Methods. The study involved 531 patients with complaints of hoarseness, of which women 337 - 63.5%, men 194 - 36.5%. We prescribed omeprasole 20 mg 30 minutes before meals in the morning for 6 weeks. Patients were questioned using the Reflux Symptom Index (RSI) questionnaire and indirect laryngoscopy with an assessment of laryngeal changes according to the Reflux Signs Scale (RSS).

Results. There was a statistically significant decrease in hoarseness 1 week after treatment, which continues to decrease 6 weeks after the initiation of treatment when evaluating the data on the RSI questionnaire. There was no statistically significant difference in the laryngoscopic picture before the start of treatment and after 1 week of treatment according to RSS; a statistically significant decrease in the quantitative assessment of RSS was revealed 6 weeks after the initiation of treatment.

Conclusions. Omeprasole at a dose of 20 mg in 30 minutes reduces the symptoms of LFR already after 1 week, the decrease in the severity of symptoms continues by 6 weeks of its use. Improvement of the laryngoscopic picture with the appointment of omeprazole 20 mg 30 minutes before meals occurs by the 6th week of its use. A positive correlation was found between the severity of LFR symptoms, including hoarseness, and the severity of changes in the laryngoscopic picture.
Role of etiotropic therapy in the treatment and prevention of influenza complications amidst the COVID-19 pandemic
Authors: Orlova N. V. , Lomaychikov V. V.
Published: December 2021

Influenza remains one of the most common respiratory viral diseases with a high risk of complications. In the context of the COVID-19 pandemic, there is a possibility of simultaneous circulation of two viruses, which makes it necessary to conduct a differential diagnosis. Influenza and COVID-19 have common pathways of transmission of the pathogen and similar symptoms, so the optimal differential diagnosis is the use of test systems for both viruses. Against the background of influenza and COVID-19, complications from various organs and systems can develop. The article describes in detail the complications of influenza from the cardiovascular system. After infection with the flu virus, there is a 6-to 10-fold increase in the risk of acute myocardial infarction and a 3 - to 8-fold increase in the risk of stroke. COVID-19 is associated with arterial hypertension, diabetes mellitus, cardiac arrhythmias, myocarditis, high risk of acute myocardial infarction, and heart failure. The article presents the data of our own research, indicating that the transferred COVID-19 disease increases the risk of acute coronary syndrome, regardless of the presence of risk factors for cardiovascular events. Prevention of the development of influenza complications is the early administration of etiotropic antiviral therapy. Numerous studies confirm the effectiveness of the neuraminidase inhibitor oseltamivir in the treatment of influenza. The use of oseltamivir reduces the severity of clinical manifestations, reduces the duration of the disease, reduces the risk of complications and death. The most effective measure to prevent influenza and COVID-19 is specific immunization. In some cases, chemoprophylaxis can be used. The article discusses studies on the effectiveness of influenza chemoprophylaxis with the use of neuraminidase inhibitors.
Role of anti-inflammatory drugs in the complex therapy of patients with carpal tunnel syndrome
Authors: Zhivolupov S. A. , Samartsev I. N. , Nazhmudinov R. Z. , Vorobieva M. N. , Vlasenko A. I.
Published: December 2021

Introduction. Carpal tunnel syndrome (CTS) is a neurological disease associated with tunnel mononeuropathies. There are various proven treatment regimens for patients with the use of conservative and surgical methods of treatment. Studies devoted to a comparative analysis of the effectiveness of methods of conservative therapy in patients with CTS are not enough to choose a treatment strategy.

Purpose of the study. To study the therapeutic efficacy of wearing a wrist orthosis with and without the use of NSAIDs in the treatment of patients with CTS.

Materials and methods. The study involved 40 patients (the average age of the participants was 32.8 ± 4.3 years) with a primary diagnosis of CTS, who were admitted to the neurological department of of the St Petersburg State Budgetary Healthcare Institution “Elizavetinskaya Hospital”, the Department of Medical Rehabilitation of St. Petersburg State Budgetary Healthcare Institution “St. Luke’s Clinical Hospital” in the period from 2017 to 2021. Patients were randomized into two comparable groups for complex conservative treatment and observation for 2 months of the dynamics of neurological symptoms, pain scale, QuickDASH questionnaire and neurophysiological parameters. The first group of patients received NSAIDs (Nimesil), 1 sachet (100 mg of nimesulide) twice a day after meals for 4 weeks, and the second group – NSAIDs with the imposition of a wrist orthosis for 4 weeks.

Results. The study involved 40 patients. The average age of the participants was 32.8 ± 4.3 years (range from 20 to 48 years). Neurophysiological indicators in the studied groups at the screening stage were comparable: distal latency of the M-response (DLMO), ms; the amplitude of the negative peak of the M-response, mV; sensory latency (SL), ms and sensory impulse conduction velocity (SSPI), m / s: 5.7, 5.3, 3.5 and 31.8 in the first group and 5.4, 5.5, 3.8 and 32.4 in the second group (p > 0.05 when comparing the corresponding parameters). After the course of treatment, significant changes in the analyzed parameters were revealed (p < 0.05).

Conclusions. In patients who received nimesulide and wore a wrist brace, the effectiveness of treatment was higher.
Ménière’s disease and chronic cerebrovascular diseases
Authors: Parfenov V. A.
Published: December 2021

Ménière’s disease (MD) is an idiopathic inner ear disease, which is characterized by noise in the ears, periodic attacks of vertigo and the development of sensorineural hearing loss. MD is characterized by endolymphatic hydrops – an increase in the volume of endolymph that fills the membered labyrinth of the inner ear. Currently highlighted subtypes MD. The first subtype meets most often and is characterized by classical manifestations of MD. The second subtype is characterized by the development of sensorineural hearing loss, to which only after a long time are joined by the episodes of dizziness. The third subtype of MD includes family cases of the disease. The fourth and fifth subtypes of MD is observed in patients with migraine and autoimmune diseases. The diagnosis of definite MD is based on the 2 or more spontaneous episodes of vertigo with each lasting 20 minutes to 12 hours, low-to medium-frequency sensorineural hearing loss in one ear, fluctuating aural symptoms (fullness, hearing, tinnitus) located in the affected ear, and lack of data for other reasons for dizziness. There are no effective treatment for auditory disorders MD, therapy is aimed at preventing dizziness attacks. The first line of MD’s therapy includes a dietary salt restriction, the use of betahistine and diuretics. Betahistine (Betaserc) is usually used in a daily dose of 48 mg for 3–6 months to reduce the frequency of vertigo. For long-term treatment, it is convenient to use a betahistine modified-released (Betaserc Long) 48 mg, taken once a day. With the ineffectiveness of conservative therapy, other methods of therapy are possible: intratympanic administration of corticosteroids or gentamicin, labyrinthectomy or vestibular neurectomy. Unfortunately, many patients suffering from BM mistakenly makes a diagnosis of cerebrovascular disease, vertebrobasilar insufficiency, cervical osteochondrosis. Diagnostic errors are usually caused by the fact that the patients with MD are not conducted audiometry, vestibular tests, and the signs of cerebral microangiopathy identified when MRI brain are mistakenly regarded as confirmation of vascular dizziness genesis.