bluuebunny/crossref_metadata_2025 huggingface dataset:
Whisker stimulation alleviate ASD behavior of BTBR mice by regulating Piezo2 expression in DRG and neuron function in S1 and mPFC
Authors: Zhai Jinhe , Hao Haiying , Xu Zihan , Li Xiaoxue , Xia Wei , Zhang Xinyi , Cao Xuan , Wang Xinxin , Li Dongxin , Wang Jia , Wu Lijie , Fan Lili
Published: March 2023

Background: Individuals with autism spectrum disorder (ASD) commonly experience sensory abnormalities, including tactile sensation, in addition to social and repetitive restrictive behavior. This study aimed to evaluate the tactile response characteristics of children with ASD and its correlation with core phenotypes, as well as investigate the role of Piezo2 mechanically sensitive ion channels in the tactile behavior of BTBR mice. Additionally, the study explored the effects of tactile intervention on the neural function of key sensory and social brain regions in mouse model.
Methods: A population questionnaire survey was conducted to compare the scores of the Short Sensory Profile (SSP) between children with ASD and typically developing children, and analyze the correlation between SSP and social response scales (SRS) and other clinical diagnostic tools in the ASD group. Behavioral tests such as Von Frey, three-chamber social test, open field, self-grooming, and Morris water maze were performed on BTBR and C57BL/6 mice to evaluate tactile and ASD characteristics. Expression of Piezo2 in the dorsal root ganglion (DRG), and the neural function in the mPFC/S1 brain region were detected in the whisker intervention group and the non-intervention group.
Results: Children with ASD showed significant tactile sensitivity compared to typically developing children, and increased tactile abnormality was associated with greater social abnormality. In animal experiments, BTBR mice with tactile overreaction exhibited over-expression of Piezo2 protein and mRNA in the DRG. Tactile intervention relieved tactile sensitivity and ASD symptoms, and decreased the over-expression of Piezo2. Additionally, there was a significant increase in dendritic spine density in S1 and mPFC brain regions, and a decrease in the level of c-fos.
Limitations: The causal relationship between ASD tactile sensitivity and social injury should be further clarified in future research. And clarify the neural mechanism of mild tactile stimulation affecting ASD symptoms.
Active Control Method for Phase and Chaos Synchronization within Two Coupled Food Chains Under Refugia and Allee Effect
Authors: Dwivedi Shubhangi , Kumari Nitu
Published: March 2023

This work investigates synchronization within a system of two coupled food chains. We assess the scenario if and how the chaotic dynamics of a food chain can be suppressed in the presence of other food chains and order can be restored within the system of coupled food chains. For this, we consider the extended version of Hasting Powell model (eHPM), in which two bio-controlling parameters, refugia, and Allee, are already present to suppress chaos. Through imperative mathematical properties and numerical simulations of the system, we first understand the impact of the interplay of refugia and Allee effects in defining the qualitative behaviour of the system. After analyzing the system's sensitive dependence on the initial condition, we use the master-slave scheme to attain synchronization within the system of two coupled food chains defined for three different frameworks. Following the active control method, Lyapunov stability theory is used to deduce the analytical expression for nonlinear active controllers for the synchronization of three different frameworks namely - (a) two identical eHPMs but with different qualitative behaviour (master eHPM possesses regular whereas slave eHPM possesses chaotic dynamics), (b) non-identical eHPM (master) and HP model (slave)~( eHPM possesses regular whereas HP model possesses chaotic dynamics), and (c) non-identical eHPM (master) and HP model (slave) with different initial conditions (both eHPM and HP model posses chaotic dynamics). Using techniques from active control theory, it is demonstrated that all three proposed systems can be phase and chaos synchronized. The time series plots of the error dynamics are used to validate that the slave system from all three frameworks adheres to the same control functions effectively for the synchronization process. Numerical simulation from the study can provide basis for assessing the potential significance of synchronization in a network of coupled food chains where Refugia and Allee effects are present.
Laplacian Nonlinear Logistic Stepwise and Gravitational Deep Neural Classification for Facial Expression Recognition
Authors: Kumari M.Binthu , Sivagami B.
Published: March 2023

Facial expression recognition is the paramount segment of non-verbal communication and one frequent procedures of human communication. Facial expression recognition, as one of the foremost evolution regulations of human-computer interaction, enhances the fluency and accuracy of relationship. Over the past few years, deep learning using feature selection of face image data based on machine and deep learning has become increasingly in demand, it has achieved progress, however due to different facial expression and attaining accuracy still remains major issue to be focused. Their accessibility shoots from their potentiality to select righteous features from face image data, via feature selection to achieve high performance at minimum time. In this work a method called, Laplacian Non-linear Logistic Regression and Gravitational Deep Learning (LNLR-GDL) for facial expression recognition is proposed. The proposed method is split into three sections, namely, preprocessing, feature selection and classification. In the first section, preprocessing is conducted with the face recognition dataset where noise reduced preprocessed face images are obtained by employing Unsharp Masking Laplacian Non-linear Filter model. Second with the preprocessed face images, computationally efficient relevant features are selected by means of Logistic Stepwise Regression-based feature selection model. Finally, Gravitational Deep Neural Classification model is applied to the selected features for robust recognition of facial expressions. The proposed LNLR-GDL method along with two state-of-the-art methods is implemented on corrective re-annotation of images for facial expression recognition. The databases comprise of consist of seven emotions viz., anger, contempt, disgust, fear, happiness, neutrality, sadness and surprise. The proposed method is compared with existing methods using three evaluation metrics namely, facial expression recognition accuracy, facial expression recognition time and PSNR. The obtained results demonstrate that the proposed LNLR-GDL method outperforms the state-of-the-art methods.
The effect of joint position sense therapy on chronic shoulder pain with central sensitisation
Authors: Chen Xin , Zha Lisi , Xuan Zhi , Zhang WeiMing
Published: March 2023

Objectives
Chronic shoulder pain is one of the common musculoskeletal problems involved with unreleased pain and functional dysfunction, and it can even evolve into central sensitisation. Some manual therapy aggravated pain and central sensitisation. Joint position sense therapy (JPST) is moderate joint proprioception training compared with vigorous exercises or aggressive hands-on therapy. This study will explore the expression of central sensitisation in chronic shoulder pain and the effect of JPST on shoulder functional dysfunction and pain.
Methods
Pressure pain threshold (PPT) was assessed together with four sites at the deltoid, upper trapezius, brachioradialis and tibialis anterior muscles among 30 chronic shoulder pain and 30 non-chronic pain patients. A total of 30 patients with chronic shoulder pain were randomly divided into the JPST group and a control group. The JPST group underwent additional shoulder joint position sense training. The efficiency outcomes were the Disabilities of the Arm, Shoulder, and Hand Questionnaire (DASH), Visual Analog Scale (VAS) and PPT evaluated at baseline and after the intervention.
Results
Significant differences were observed in PPT values at brachioradialis (P < 0.05), deltoid (P < 0.01) and trapezius (P < 0.001) among non-chronic and chronic groups, but not in tibialis anterior muscle (P > 0.05). Although both control and JPST intervention were effective in improving DASH, pain intensity and PPT values in the upper limb, outcomes in the JPST group showed significant differences from the control group.
Conclusions
A generalised hyperalgesia changes limited to the upper limb were noticed in chronic shoulder pain. Joint position sense therapy had a beneficial effect on pain control and functional dysfunction in chronic shoulder pain patients.
Comparison of calcaneal plate fixation and Philos plate fixation for the treatment of split fractures of the greater tuberosity of the humerus: a retrospective review
Authors: Wang Fei , Niu Xiaohui , Xia Haibo , Liang Wei , Lan Jun
Published: March 2023

Objective To compare the effect of two internal fixation methods of calcaneal plate fixation and Philos plate fixation for the treatment of split fractures of the greater tuberosity of the humerus.
Methods A retrospective analysis was carried out on the data of 37 patients with isolated split fractures of the greater tuberosity of the humerus treated in our hospital from September 2016 to April 2021. There were 24 males and 13 females, with an average of 46.7 (25-67) years old. All patients had fresh split fractures with displacement of >5mm and without other injuries (such as Bankart injury, SLAP injury and Hill-sachs injury). Enrolled patients were divided into two groups according to different internal fixation methods. Patients in group A were treated with calcaneal anatomical locking plate (n=16), and those in group B were given Proximal Humeral Internal Locking System (PHILOS) (n=21). Further comparison was conducted on the interval from injury to operation, length of incision, operation time, bleeding volume, postoperative Constant-Murley shoulder joint function score and complications between the two groups.
Results All the 37 cases had fracture healing during the follow-up period ranging from 10-23 months, with an average of 11.9 months. The average interval from injury to operation was 3.7 days (2-4 days) in group A and 4.1 days (3-6 days) in group B, with no significant difference. The average length of incision was 6.2cm (4.5cm-7.3cm) in group A and 9.1cm (8.2cm-10.7cm) in group B, with significant difference. The average operation time was 61 minutes (51-77 minutes) in group A and 65 minutes (57-79 minutes) in group B, with no significant difference. There was significant difference in the comparison of bleeding volume between group A and group B [47ml (35ml-63ml) vs. 103ml (79ml-125ml)]. During the 6-month follow-up, the average Constant-Murley score was 87.5 points (76-97 points) in group A and 80.3 points (71-91 points) in group B, with significant difference. In addition, shoulder impingement syndrome occurred in 2 cases in group B, but not in group A.
Conclusion Calcaneal anatomical locking plate can achieve satisfactory results in the treatment of adult fractures of the greater tuberosity of the humerus, with the advantages of less surgical trauma and less bleeding. Findings in our study can provide a new choice for the surgical treatment of isolated fractures of the greater tuberosity of the humerus.
KIF21B acts as an oncogene in hepatocellular carcinoma through the NF- κB/p65 signaling pathway
Authors: Chen Shi-Yong , Dong Xiao-Hua , Chang Jian-Hua , Dong Bao-Long , Yang Zi-Jiao , Wang Xin-Xin , Gao Peng , Cai Hui , Yang Xiao-Jun
Published: March 2023

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Its invasiveness and ability to metastasize contributes to an extremely high patient mortality. However, the molecular mechanisms that underlie the characteristics of HCC progression are not well understood. The kinesin superfamily 21 B (KIF21B) has been shown to be involved in hepatocellular carcinoma (HCC). Nevertheless, its role in HCC has not yet been thoroughly examined. Tumor Genome Atlas (TCGA) was used to analyze the difference of KIF21B expression between HCC and normal tissues and its relationship with clinicopathological features. For further validation, immunohistochemistry (IHC) was used to detect the expression of KIF21B in 116 cases of liver cancer. In vitro studies, we used loss-of-function assays to evaluate the effects of KIF21B and its direct target NF-κB(nuclear factor-κB) p65 subunit on cell growth, proliferation, apoptosis, migration, invasion, and epithelial-mesenchymal transition (EMT).Then the effect of KIF21B inhibition on tumor growth was studied in nude mice in vivo. We demonstrated that elevated KIF21B expression is associated with adverse clinicopathological features, such as tumor size, in HCC patients. In vitro experiments showed that silencing KIF21B could inhibit the proliferation, migration, invasion and EMT of HCC cells, and induce apoptosis, while overexpression of p65 could reverse these effects. In addition, silencing of KIF21B inhibited the growth of HCC in xenografts in nude mice. In this study, we identified and validated that KIF21B plays a carcinogenic role in HCC through NF-κB/p65 signaling pathway, providing a new insight into HCC pathogenesis and therapeutic possibilities.
Functional validation of squalene epoxidase in triterpenes biosynthesis in Poria cocos by molecular docking and CRISPR-Cas9 gene editing
Authors: Liu Xiaoliu , Xie Jing , Xie Zhenni , Zhong Can , Liu Hao , Zhang Shuihan , Jin Jian
Published: March 2023

Background
Squalene epoxidase is one of the rate-limiting enzymes in the biosynthetic pathway of membrane sterols and triterpenoids. The enzyme catalyzes the formation of oxidized squalene, which is a common precursor of sterols and triterpenoids. In recent years, CRISPR/Cas9 gene editing technology has emerged and other functional genes in the Poria cocos triterpene synthesis pathway have been studied; PcSE has not been reported.
Results
In this study, the squalene epoxidase gene (PcSE) was evaluated in Poria cocos. Molecular docking between PcSE and squalene was performed and the active amino acids were identified. sgRNA sequences were designed based on the active site residues. In vivo verification of PcSE function was performed using a PEG-mediated protoplast transformation approach. The effect on triterpene synthesis in P. cocos was consistent with the results from ultra-high-performance liquid chromatography-quadruplex time-of-flight-double mass spectrometry (UHPLC-QTOF-MS/MS) analysis. Which showed that deletion of PcSE inhibited triterpene synthesis.
Conclusions
A gene editing system based on molecular docking was successfully constructed to demonstrate that PcSE functions as a house squalene cyclooxygenase, which provides a basis for further studies on the heterologous biosynthesis of P. cocos secondary metabolites.
Waste to resource: An approach towards end-of-life investigation of defense used boot of Bangladesh for sustainable environment
Authors: Sujan SMA , Sarker Shashanka Shekhar , Mahmud Yead , Tamanna Al , Debnath Akash , Alam Md. Ashraful , Mizan Al , Uddin Md. Tushar
Published: March 2023

After a certain period or end-of-life (EoL), all the valuable products become waste if they are not properly managed. This study reveals the appropriate and sustainable pathway to manage the various solid wastes coming from used footwear (boots) of the Bangladesh Armed Forces and other Forces. The major parts separated from the collected four pair of used boots include leather, thermoplastic rubber (TPR) materials (e.g., sole, toe puff, stiffener, etc.), laces, metal shank, metal eyelet, etc. Careful observation of the used boots and its separated parts indicated 92-96% damage of the boots after the use of the boots for six months. Based on the properties of different parts of used boots, an integrated 4R’s waste management (reuse, recycle, recovery, and reduce) concept was introduced. It helps to minimize greenhouse gas, smog, heavy metals, dyes, pigments, and other pollutants emission to the atmosphere, thereby reducing the severe health consequences, environmental pollution, and climate change. This paper also discusses the critical aspects of various materials obtained from the post-consumer used boot through different mechanical, thermochemical, and chemical treatment processes.
Cytotoxicity Evaluation of Eucalyptus camaldulensis leaf extract against Cholangiocarcinoma Cell lines (CL-6)
Authors: Amuamuta Asmare , Berihun Birhanu
Published: March 2023

Background

Cholangiocarcinoma(CCA) is an important public health problem in many tropical and subtropical parts of the world. Eucalyptus camaldulensis leaves as well as its essential oil extracts are well known for its traditional use and pharmacological actions including insect repellant/insecticidal activity, antimicrobial, cytotoxic/anticancer activity as well as for many other disorders in different parts of the world including Africa and Southeast Asia.

Materials and Methods

This study was conducted to investigate the cytotoxic activity of E. camaldulensis leaf extract preparations at in vitro against the CCA tumor (CL-6 cell line). E. camaldulensis leaves collected from Ethiopia (Western Gojjam and Southern Gonder area) was used for extract preparation in 95% ethanol using different extraction methods, i.e.,ultrasonication, heating reflux, and maceration (1 day, 3 days and 7 days). The extract and the standard anticancer drug preparation 5-fluorouracil (5-FU) were evaluated in triplicate for their cytotoxic activities against CL-6 cell line and normal human cell line (OUMS) using standard MTT cell proliferation assay at eight serial dilution concentrations (3.8–500µg/mL).

Results

A semi-solid brown black residue with a characteristic odor was obtained after solvent removal and extract concentration was done by using a rotary evaporator at 60oC. The highest (mean ± SD) percent yield (3.73 ± 0.61) was obtained by using maceration technique with the solvent for 7 days, followed by heating reflux (1.73 ± 0.80) and the least was obtained from 1day maceration method (0.90 ± 0.52). The extract was then stored at -20oC until use. The cytotoxic activity (mean ± SD IC50 values) E. camaldulensis extract and 5-FU against CL-6 were 102.29 ± 5.87 and 106.75 ± 3.06 (mean IC50 ± SD) µg/mL, respectively. The extract’s IC50 value observed in normal OUMS cell line was 165.9 ± 10.3.

Conclusion

The extract of E. camaldulensis collected from the study area exhibited in vitro cytotoxic activity against human CCA tumor cell line (CL-6). Further in vitro and in vivo evaluation of the selected herbal extract preparation is recommended in the search for development of safe and promising drug options against CCA and other cancer types.
Virtual flavonoids screening identifies potent compounds against enterovirus A71 and coxsackievirus A16
Authors: Sripattarp Amita , Sanachai Kamonpan , Chavasiri Warinthorn , Wolschann Peter , Langer Thierry , Boonyasuppayakorn Siwaporn , Rungrotmongkol Thanyada
Published: March 2023

Worldwide outbreaks of hand, foot, and mouth disease (HFMD) are caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Since no anti-HFMD drugs are currently available, it is interesting to study potential viral inhibitors. Rupintrivir is a rhinovirus 3C protease (3Cpro) inhibitor with apparent inhibitory activity against HFMD. This study constructs pharmacophore models of the EV-A71 and CV-A16 3Cpro complexed with rupintrivir using molecular dynamics (MD) simulations. Both models had similar pharmacophore features, including hydrogen bond donors and acceptors and hydrophobic interactions. These pharmacophore models were then used as a template to screen 39 flavonoid compounds as potential novel inhibitors. Diosmin, epigallocatechin gallate (EGCG), and RTH-011 showed high binding affinities for EV-A71 and CV-A16 3Cpro. They formed hydrogen bonds with important surrounding residues in both proteins, including H40, L127, T142, A144, T145, H161, I162, G163, and G164. In addition, their effective concentrations against rhabdomyosarcoma (RD) cell infection by EV-A71 and CV-A16 were determined. EGCG had the highest half maximal effective concentration (EC50) of 12.86 ± 1.30 µM for EV-A71 and 15.54 ± 1.50 µM for CV-A16, while diosmin had EC50 of 21.01 ± 1.57 µM for EV-A71 and 30.68 ± 3.25 µM for CV-A16. Both compounds were non-toxic in RD cells, with 50% cytotoxic concentrations of > 100 µM for EGCG and > 500 µM for diosmin. In addition, MD simulation analysis showed that EGCG had a higher binding affinity than diosmin, supported by its significantly lower solvated binding free energies and greater numbers of contact atoms and key binding residues. Moreover, previous studies reported EGCG’s inhibitory effect on other viruses, such as severe acute respiratory syndrome coronavirus 2. Therefore, our findings suggest that EGCG can effectively inhibit the EV-A71 and CV-A16 3Cpro.
Research on anti-impact performance of steel fiber reinforced concrete based on finite element and machine learning
Authors: Zhao Jingshuo , Yang Xiaolin , Gao Shiwu , Ma Hongwei
Published: March 2023

To predict the impact resistance of steel fiber reinforced concrete (SFRC), 50 specimens with different fiber lengths and different fiber contents were loaded using ABAQUS finite element software to obtain data in this paper. Two machine learning (ML) models, backward propagation-artificial neural network (BP-ANN) and support vector machine (SVM), were used to train the data. The results show that in the prediction of the impact resistance of steel fiber reinforced concrete by this model, the deviation of the predicted values from the real values is small, and the two models are well fitted. To further optimize the model, the parameters of the prediction model were adjusted using the whale optimization algorithm (WOA) in this paper, and the accuracy of the optimized model was significantly improved. After optimization, the WOA-BP-ANN and WOA-SVM models have better generalization ability and higher prediction accuracy than the WOA-SVM model.
Diverse News For Young Minds: Scandinavian Perspectives
Authors: Katerynych Petro
Published: March 2023

This study analyzes the visual, content, and digital diversity in newspapers for children in the Scandinavian region, focusing on Aftenposten Junior (Norway), SvD Junior (Sweden), and Postimees Juunior (Estonia). Our findings show that all three newspapers demonstrate a commitment to diversity in their content and visuals, but their approaches vary. Aftenposten Junior focuses on environmental and political issues, while SvD Junior emphasizes cultural diversity and social justice. Postimees Juunior has a stronger focus on children’s interests and activities. The study highlights the importance of diversity in newspapers for children and provides insights for publishers and editors to engage young readers through relevant content and visuals.
Low-energy effective description of dark $Sp(4)$ theories
Authors: Kulkarni Suchita , Maas Axel , Mee Seán , Nikolic Marco , Pradler Josef , Zierler Fabian
Published: March 2023

Strongly interacting massive particles are viable dark matter
candidates. We consider a dark Sp(4)Sp(4)
gauge theory with N_f=2Nf=2
fermions in the pseudo-real fundamental representation and construct the
chiral low-energy effective theory. We determine the flavour multiplet
structure and the chiral Lagrangian, including the Wess-Zumino-Witten
term for mass-degenerate and non-degenerate flavours. We then study the
possible charge assignments under a U(1)'U(1)′
gauge symmetry, emphasizing on dark state stability, and provide the
full Lagrangian description for Goldstone bosons and vector resonances,
including the Wess-Zumino-Witten term. Finally, we use dedicated lattice
simulations to determine the chiral low-energy effective theory’s
validity and low-energy constants. This work represents a
self-consistent study of this non-Abelian theory. It thereby provides a
framework for future phenomenological exploration in connection to the
dark matter problem.
Macroscopic fluctuation theory and current fluctuations in active lattice gases
Authors: Agranov Tal , Ro Sunghan , Kafri Yariv , Lecomte Vivien
Published: March 2023

We study the current large deviations for a lattice model of
interacting active particles displaying a motility-induced phase
separation (MIPS). To do this, we first derive the exact fluctuating
hydrodynamics of the model in the large system limit. On top of the
usual Gaussian noise terms the theory also presents Poissonian noise
terms, that we fully account for. We find a dynamical phase transition
between flat density profiles and sharply phase-separated traveling
waves, and we derive the associated phase diagram together with the
large deviation function for all phases, including the one displaying
MIPS. We show how the results can be obtained using methods similar to
those of equilibrium phase separation, in spite of the nonequilibrium
nature of the problem.
CRITICAL ANALYSIS OF R.K NARAYAN IN HIS INDIAN SOCIAL PHILOSOPHY
Authors:   Department of English Literature, Jayoti Vidyapeeth Womens University, Jaipur (Rajasthan), India., Bala Madhu , Devi Suman ,   Department of English Literature, Jayoti Vidyapeeth Womens University, Jaipur (Rajasthan), India.
Published: March 2023

R.K Narayan was the keen observer of the 20th century society, this is the reason, and we can see the different elements of social norms in his writings. His psychological phenomena can be seen in his works and writings because through his writings he has incarnation of true meaning of Indian life and Indian culture. Narayan himself bears many problems so that he was deep rooted with his writings. We can see the great coordination of his hand and mind whatever he has written totally related to his experience. The objectives of this paper are to analysis the R.K Narayans social philosophy and his childhood impact over his writings. Swami and Friends was the first book which based on his childhood incidents or it is semi autobiographical novel. It was very famous episode in Malgudi Days tv serial. Through his novels one can know about the real situation of women, in the novel The Guide Narayan portraits the picture of women through the character of Rosie. She is the character who fights between the traditional norms and liberation. Narayans women were shy, they feel guilt if they protest in favor of theirs rights.
KNOWLEDGE OF HANDWASHING AMONG THE MEDICAL AND NURSING PROFESSIONALS OF A TERTIARY CARE TEACHING HOSPITAL IN SOUTH GUJARAT, INDIA AFTER COVID - 19 PANDEMIC: A CROSS-SECTIONAL STUDY
Authors:   Senior Resident, Department of Community Medicine, Government Medical College, Surat., Bodar Kavita , Engti Raktim ,   Senior Resident, Department of Community Medicine, Government Medical College, Surat., Chaudhari Vipul ,   (MD Community Medicine), Associate Professor, Department of Community Medicine, Government Medical College, Surat., Kosambiya J.K. ,   (MD Community Medicine, DCM), Professor & Head, Department of Community Medicine, Government Medical College, Surat.
Published: March 2023

Background:Overall, many patients get affected by Hospital Associated Infection (HAIs) every year. Hand hygiene (HH) has been distinguished as the absolute most significant component in preventing HAIs. The point of this study was to decide the knowledge in regards to hand cleanliness among health care personnel, and recognizing the loopholes in their insight. Objective: This study aims to explore knowledge regarding hand hygiene among health care personnel. Methodology: This is a cross sectional study in Surat among 174 medical and paramedical participants selected from New Civil Hospital by Purposive Sampling. Data collection was done by digital form asking to fill up the WHO hand hygiene questionnaire for health care workers during the month of August - September, 2022. Univariate analysis was done followed by Chi square test to establish associations. Results: Mean age of population was 24.9Â±5.6 years. Knowledge score was classified into good (â‰¥75%), moderate (50-75%) and poor (<50%). Majority of them had moderate knowledge (62.2%). The routine use of alcohol was significantly associated with receiving formal training in last 3 years (Ì’Ï‡2:15.890, DF=1, p=0.000). Conclusion: Despite training, paramedical staff have just moderate comprehension of hand hygiene, although medical students, on the contrary, have great grasp.
DHARMA AND LAW
Authors: S. Dinesh
Published: March 2023

Dharma have been derived and supersede from the vedic concept of Rita, which literally meant, the straight line. Rita refers to the Law of Nature, it signifies moral laws, and based on righteousness. When something is Rita it simply meant that thing is true, right and nothing more. Dharma signifies natural law. Anything is right, just and moral is Dharma.
SYNTHESIS AND INVESTIGATING OF THE NOVEL OF ES-PANI@PDNPSNANOCOMPOSITE
Authors:   Departement of Chemistry, Faculty of Mathematics and Natural Sciences Jember University, Jl. Kalimantan 37, Jember 681752., Busron Busroni , a Suyanta ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences Gadjah Mada University, Jl. Sekip Utara, Yogyakarta 55281., Anwar Chairil ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences Gadjah Mada University, Jl. Sekip Utara, Yogyakarta 55281.
Published: March 2023

The aim of this research is the synthesize materials Novel of ES-PANI@PdNPs nanocomposites obtained chemically. The synthesis of ES-PANI@PdNPs nanocomposite was prepared by the chemical method using FeCl3 as a redox initiator (insitu) and refluxed for 48 hours at 500C, then dried at 500C for 24 hours, obtained a brown-black solid and no water-soluble.The nanocomposite is characterized by UV-Vis and Fourier transform infrared (FTIR) spectroscopy, the composite shows absorption of Pd(0) nanoparticles along with ES-PANI peaks at 312 nm. FTIR and UV-visible spectra show an interaction between Pd(0) and ES-PANI. This indicated that Pd(0) zero valence had been formed and that internal reduction processes had occurred by imines and amines toward Pd(II) ions.
A CLINICAL STUDY OF LODHRA KALKA PAAN WITH NYAGRODH TWAK KASHAYA AND PANCHAVALKALADI VARTI IN SHWETA PRADARA (W.S.R TO LEUCORRHOEA)
Authors:   Assit. Prof., Dept of Prasuti Tantra Avun Sri Rog , Major S D Singh P G Ayurvedic Medical College & Hospital, Farrukhabad, UP., Yadav Shweta , Saxena Jolly ,   Principal, Prof & HOD, Dept, of Rasa Shastra & Bhaishjya Kalpana, Major S D Singh P G Ayurvedic Medical College & Hospital, Farrukhabad, UP., Saxena Ankur ,   Assit. Prof., Dept of Roga Nidan & Vikriti Vijyan , Major S D Singh P G Ayurvedic Medical College & Hospital, Farrukhabad, UP., Biswal Debasis ,   Prof & HOD, Dept of Kaya Chikitsa, Major S D Singh P G Ayurvedic Medical College & Hospital, Farrukhabad, UP., Kumar Pandey Arun ,   Assit. Prof., Dept of Swasthavrita, Major S D Singh P G Ayurvedic Medical College & Hospital, Farrukhabad, UP.
Published: March 2023

Shwetapradara or Leucorrhoea is a common symptom of genital tract infection in women. The World Health Organization estimated that there are 333 million new cases of curable Vulvo-vaginal infections (VVIs) per year. Physiological excess of vaginal discharge does not require any treatment. But the pathological conditions which necessitate treatment are those involving many infections due to Candida, Trichomonas, Gram negative, Gram positive etc. organisms. For the treatment of Shwetapradara many Kashaya drugs are available in classics. From such recipes, Lodhra Kalka Paan with Nyagrodh Twak Kashaya and Panchvalkaladi Varti has been selected in one group and in other group Panchvalkaladi Varti is selected. Lodhra Kalka Paan with Nyagrodh Twak Kashaya and Panchavalkaldi Varti had shown statistically highly significant result on Yonigata symptoms i.e. Yoni Kandu, Yoni Daurgandhya, Yoni Vedana, Yoni Pichchhilata and Yoni Daha, associated symptoms like Katishoola, Udarashoola, Mutradaha & gynaecological complains i.e. Vaginitis, Cervicitis, Vulvitis & in relieving pus cells, fungal hyphae and Gram-ve organism but on basis of percentage relief and inter group comparison better response was observed in trial group A receiving Lodhra Kalka Paan with Nyagrodh Twak Kashaya and Panchavalkaldi Varti. The overall effect of the therapy on 106 patients of Shwetapradara in both groups was evaluated. 86.20%of patients in the Group A and 68.75% of patients in Group B were improved completely. 10.34% of patients in Group A and, 16.66% of patients in Group B were markedly improved. While only14.58% patients were improved in Group B.
LA STEATOSE HEPATIQUE AIGUE GRAVIDIQUE : A PROPOS DE 7 CAS ET REVUE DE LA LITTERATURE
Authors:   Department of Gynecology and Obstetrics, MohammedVI University Hospital, Oujda, Morocco., Chatbi Zaineb , Rhazi Inas ,   Faculty of Medicine and Pharmacy, Mohammed 1st University, Oujda, Morocco.
Published: March 2023

Introduction : La steatose hepatique aigue gravidique (SHAG) est une urgence medico-obstetricale compte tenu de son taux eleve de morbi-mortalitematerno-fÅ“tale. Il sagit dune microsteatose hepatocytaire provoquant une insuffisance hepatocellulaire aigue associee a un troublede lhemostase et a une insuffisancerenale pouvant rapidement engager le pronostic maternel. Nous rapportons les cas de 7patientes atteintes de steatose hepatique aigue gravidique au sein du CHU Mohammed VI dOujda, sur une periode de 3 ans. Le but de cette mise au point est dexposer les differents cas rencontres ainsi que de rappeler les manifestations cliniques et biologiques de la SHAG, les principaux elements du diagnostic, du pronostic et du traitement. Conclusion: Lasteatose hepatique aigue gravidique est une complication rare mais gravissime de la grossesse. Un ictere associe a une hypoglycemie au 3e trimestre sont evocateurs de SHAG. Le diagnostic doit etre precoce, et la prise en charge rapide afin dameliorer le pronostic maternel qui peut rapidement etre engage.
TERIPARATIDE - THE FUTURE OFHOST MODULATION ANDPERIODONTAL REGENERATION? A SHORT REVIEW
Authors: Saripalli Nidhi , Sabharwal Aishwarya
Published: March 2023

Periodontal disease is multifactorial and infectious, and can lead to loss of the dentition. Multiple treatment modalities have been used and experimented upon over several years. The main objective of periodontal therapy is to arrest the bone loss and help in its regeneration. Teriparatide is a type of recombinant human parathyroid hormone, which can aid in alveolar bone regeneration in treating periodontal conditions. This review discusses the mechanism and applications of teriparatide in periodontics and its potential use in host modulation and periodontal regeneration.
A COMPARATIVE EVALUATION OF EFFICACY OF TETRACYCLINE HCL, EDTA & HYALURONIC ACID GEL AS ROOT BIOMODIFICATION AGENTS. -AN IN-VITRO SEM STUDY
Authors: Choudhary Srishti , Chopra Rahul , Chandra Joohi , Malhotra Sumit
Published: March 2023

Background: Scaling and Root Planing alone leaves a smear layer on the root surface which may interfere with reattachment of cells to root surface during regenerative periodontal therapy. Root bio-modification has been advocated for smear layer removal which may enhance regeneration. Objective: To evaluate and compare effect of 17% Ethylenediamine Tetra Acetic acid (EDTA), Tetracycline HCL and 1% Hyaluronic Acid gel as root conditioning agents on periodontally involved root surfaces of extracted teeth using a scanning electron microscope (SEM). Materials And Method: Freshly extracted 10 single rooted human teeth were sectioned into 30 samples and were segregated into 3 groups: 1. Group â… - tetracycline HCl (pH 1.6), 2. Group â…¡ â€“ EDTA 17% (pH 7.3), 3. Group III â€“ HA gel 2%. The samples were treated with respective agents and were viewed under 4000X magnification using a SEM. The specimens were assessed for the Residual smear layer score, Number of patent tubules, Total number of dentinal tubules, Proportion of patent to total number of dentinal tubules and Mean Diameter of dentinal tubules. Results: Group I and Group II were significantly better than Group III for all the measured parameters. However, the number of patent dentinal tubules, total number of dentinal tubules and mean diameter of dentinal tubules were significantly superior in Group II as compared to Group I. Conclusion: Tetracycline HCL was found to be the most effective root conditioning agent amongst the 3 groups, for the assessed parameters.
ATYPICAL PRESENTATION OF GENITAL CHLAMYDIA
Authors:   MBBCH - Tanta University, Egypt MD - Ain Shams University Egypt Gyne Specialist Prime Hospital, Dubai., Saad Hassanin Ebtessam , Kouteich Khaled ,   MD, DES, FCOG, ESGO Consultant Gyne Oncologist. Prime Hospital Dubai.
Published: March 2023

Chlamydia is one of the most common sexually transmitted infections all over the world. It is passed on through unprotected sex (sex without a condom) and is particularly common in sexually active teenagers and young adults. Most people with chlamydia do not notice any symptoms and do not know they have it. Although chlamydia does not usually cause any symptoms and can normally be treated with a short course of antibiotics, it can be serious if its not treated early if left untreated, the infection can spread to other parts of your body and lead to long-term health problems, such as pelvic inflammatory disease (PID). And infertility. It can also sometimes cause arthritis. Rare complication is perihepatitis (Fitz Hugh Curtis syndrome).our rare case, presented with abdominal discomfort, ascites and elevated CA125, no genitourinary symptoms.
The board of directors influence on the information quality of financial reporting through accounting conservatism – Empirical evidence on Vietnamese listed enterprises
Authors: Anh Tuan Dang , Quoc Thinh Tran , Xuan Thuy Le
Published: March 2023

The information quality contained in financial reporting has practical implications for stakeholders. Accounting conservatism is a criterion that affects the authentication of the value of assets and liabilities related to the financial reporting of enterprises. The role of the board of directors is to supervise the information quality of an enterprise. The purpose of the paper is to examine how the board of directors influences the information quality of financial reporting through accounting conservatism. The survey sample includes 100 listed enterprises that have the highest capitalization in Vietnam’s stock market. Time series data taken for the last five years are published by enterprises from 2018 to 2022. The paper implements the quantitative method of ordinary least squares to test the hypotheses. The results explore that board size, board independence, and audit organization affect the information quality of financial reporting through accounting conservatism. Accordingly, board size has the strongest influence, and board independence has the weakest effect on the information quality of financial reporting through accounting conservatism. The research suggests some policies for Vietnamese listed enterprises to have appropriate regulations for the board of directors and strengthen control of the information quality of financial reporting.
Espaço social reificado, espaço de sociação e territórios
Authors: Menezes Amaral João Flávio
Published: March 2023

Este artigo articula a teoria social de Bourdieu, o campo da análise de redes sociais e a concepção de Haesbaert de territórios, propondo um quadro teórico para uma interpretação relacional da segregação e fragmentação urbana como processos de (re)produção do espaço social. Propomos uma ênfase em uma "tradução integrada" do espaço social. O espaço simbólico da cultura; o processo de reificação do espaço social como apropriação do espaço físico; e o que definimos como 'espaço de sociação' - referindo-se às redes sociais como estruturas de ligação e interação também orquestradas pelo funcionamento do habitus - são mostrados como 'estruturas estruturantes' inter-relacionadas em processos multiescalares e multidimensionais de (des)territorialização urbana. Desta forma, oferecemos uma matriz conceitual que interpreta diferentes e complexas formas de divisão socioespacial a partir do mesmo princípio agonístico de disputas por recursos socialmente posicionais.
The Protective Effect of the Asystasia chelonoides Extracts on Hypertensive
Nephropathy Rats
Authors: Duan Tingting , Li Minyi , Lie Beifeng , Lin Ziyang , Li Mengqiu , Xia Tao , Lin Guixuan , Meng Lanqing , Lu Xiuqing , Li Zhenghai , Yang Junzheng
Published: March 2023

Background:

Hypertensive nephropathy (HN) is one kind of kidney disorders caused
by long-term uncontrolled hypertension, usually resulting in severe kidney damage, including
inflammation and oxidative stress, no matter in cells or tissues, from patients with nephropathy. In
recent years, nephropathy accompanied by hypertension is becoming one of the main causes for
kidney replacement therapy, but few effective treatments have been reported for HN treatment.
Asystasia chelonoides (AC) is a kind of plant with the effects of anti-inflammation, lowering blood
pressure, and anti-oxidative stress. Still, the therapeutic effect of AC in HN rats is not clear.

Methods:

To establish HN model by feeding high sugar and high fat diet spontaneously hypertensive
rats. Blood measurement, HE staining, PAS staining and biochemical analysis and were used
to assess the therapeutic effects of AC extracts and western blotting analyzed the underlying
mechanisms of AC extracts treatment in the HN rat model.

Results:

AC extracts could significantly lower systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) in HN rats; and reduce the expression of total protein (TP), blood urea nitrogen (BUN), microalbuminuria (MALB), creatinine (Cr), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol (LDL-C) concentrations, and also could down-regulate expression of IL-6, MDA and AGEs, up-regulate the expression of SOD in HN rats; HE staining and PAS staining demonstrated that AC extracts could alleviate the histopathological changes in HN rats; western blotting demonstrated that AC extracts could up-regulate the expression of PPARγ and down-regulate the expression of TGFβ1 and NF-кB in HN rats.

Conclusion:

The finding of the article demonstrated that AC extracts had the better therapeutic
effect for HN, and provided the pharmacological evidences for AC extracts treatment for HN.
Pyrazole Scaffolds Having Promising Pharmacological Potential: A Review
Authors: Singh Sucheta , Tehlan Sumit , Kumar Verma Prabhakar
Published: March 2023

Heterocyclic compounds have diverse structure, which makes them broad and economical
therapeutic agents. Pyrazole is a five-membered aromatic ring that contains two nitrogen atom and is
responsible for the diverse functions of heterocyclic compounds. This implies the need of reviewing
the work that already has been done on the potential of pyrazole scaffolds in the field of medicinal
chemistry for the synthesis of new compounds with more effective antimicrobial, antioxidant, anticancer,
anti-tuberculosis, and anti-inflammatory activities.
Functional Nutrition as Integrated Intervention for In- and Outpatient
with Schizophrenia
Authors: Matrisciano Francesco
Published: March 2023

Schizophrenia is a chronic and progressive disorder characterized by cognitive, emotional,
and behavioral abnormalities associated with neuronal development and synaptic plasticity alterations.
Genetic and epigenetic abnormalities in cortical parvalbumin-positive GABAergic interneurons and
consequent alterations in glutamate-mediated excitatory neurotransmission during early neurodevelopment
underlie schizophrenia manifestation and progression. Also, epigenetic alterations during
pregnancy or early phases of postnatal life are associated with schizophrenia vulnerability and inflammatory
processes, which are at the basis of brain pathology and a higher risk of comorbidities, including
cardiovascular diseases and metabolic syndrome. In addition, schizophrenia patients adopt an
unhealthy lifestyle and poor nutrition, leading to premature death. Here, I explored the role of functional
nutrition as an integrated intervention for the long-term management of patients with schizophrenia.
Several natural bioactive compounds in plant-based whole foods, including flavonoids, phytonutrients,
vitamins, fatty acids, and minerals, modulate brain functioning by targeting neuroinflammation
and improving cognitive decline. Although further clinical studies are needed, a functional diet
rich in natural bioactive compounds might be effective in synergism with standard treatments to improve
schizophrenia symptoms and reduce the risk of comorbidities.
Recent Discovery of Triazine Derivatives as Protease Inhibitors for the
Treatment of Coronavirus-19 (COVID-19)
Authors: De Surya K.
Published: March 2023

The present application describes a class of compounds exhibiting a
coronavirus 3CL protease inhibitory effect and pharmaceutically acceptable
salts thereof, and a pharmaceutical composition containing the same. The application
also provides the synthesis of compounds and efficacy from in vitro
and cell- based assays.
Centenary of Insulin Therapy: A Review
Authors: Zargar Abrar Ahmad , Kumar Ranjeet , Kumar Arvind , Gangwar Ruby , Sharma Amit
Published: March 2023

Insulin is an endocrine hormone produced by the beta cells of islets of Langerhans in the
pancreas. It regulates blood sugar levels and various anabolic activities such as glycogenesis and
lipid synthesis. Despite the fact that insulin therapy has been around for 100 years, insulin formulations
are continually being improved to lower the risk of hypoglycaemia and other adverse effects,
including weight gain. The development of insulin pens has significantly reduced the consequences
of hypoglycaemia instead of vials and syringes. Both injectable devices were well-received by the
patients. In the population under study, the efficacy and safety profiles of the pen appeared to be
comparable to those of the vial/syringe. However, more patients reported that they would like to
keep using pen devices. This article aimed to summarize the background of insulin, its mechanism,
types, needle size, injection technique, adverse drug reactions and various studies related to insulin.
It has been recommended intensive treatment of type-1 and type-2 diabetes patients to achieve
good metabolic control and avoid chronic complications caused by poor glycaemic control.
Healthcare professionals should address concerns about safe and effective implementation of inpatient
hypoglycaemic control and insulin usage and they should empower patients to self-manage
their diabetes, so they may improve their quality of life as well as avoid potential complications.
Much more progress is expected in the future, at a faster pace, based on the implementation of
well-organized recovery efforts, advancing technologies, and scientific collaboration.