bluuebunny/crossref_metadata_2025 huggingface dataset:
Etnografía del aprendizaje pugilístico en un club deportivo amateur de Temuco (Chile) (Ethnography of pugilistic learning in an amateur sports club in Temuco (Chile))
Authors: Riquelme Brevis Hernán
Published: November 2022

El objetivo del artículo es caracterizar y describir las lógicas deportivas que implica el pugilismo en jóvenes que participan activamente de la rama de boxeo de un club deportivo de la ciudad de Temuco, Chile. Para ello, se contempló la etnografía como método de investigación que permite captar las interacciones sociales en el marco de la observación del lenguaje corporal y visual de los deportistas involucrados. Dentro de los hallazgos se visualizan comportamientos que permiten enaltecer el deporte como actividad que propicia la autosuperación, la reconfiguración de los cuerpos a tenor de movimientos que se realizan a contracorriente de la naturaleza humana, el cansancio y el dolor como sensaciones ciertamente censuradas en el marco de los entrenamientos, el papel del entrenador como agente fundamental en el proceso cognitivo y las dificultades/ventajas que implica la práctica de un deporte donde el cuerpo es herramienta de ataque y defensa.
Palabras clave: etnografía, boxeo, cuerpo, deporte, amateurismo.
Abstract. The objective of the article is to characterize and describe the sports logics that involve pugilism in young people who actively participate in the boxing branch of a sports club in the city of Temuco, Chile. For this, ethnography is contemplated as a research method that allows capturing social interactions within the framework of observing the body and visual language of the athletes involved. Among the findings, behaviors are observed that allow sport to be extolled as an activity that promotes self-improvement, the reconfiguration of bodies according to movements that are carried out against the current of human nature, fatigue and pain as sensations that are certainly censored in the framework training, the role of the coach as a fundamental agent in the cognitive process and the difficulties/advantages involved in practicing a sport where the body is a tool of attack and defense.
Keywords: ethnography, boxing, body, sport, amateurism.
Implementação do PELC em contexto universitário: participação popular, possibilidades e limitações ao esporte e lazer estudantil
Authors: Silva Junior Vagner Pereira da , Ungheri Bruno Ocelli
Published: November 2022

O estudo objetivou investigar a implementação de dois núcleos do PELC em uma Instituição Federal de Ensino Superior em Campo Grande/MS e a participação popular na estruturação. Trata-se de uma pesquisa exploratória e documental, com análise de conteúdo. Os resultados indicam que a implementação do programa ocorreu a partir da consulta online junto a população sobre sua preferência em relação ao conteúdo, dias e horários dos atendimentos, com as tomadas de decisão dos gestores, em sua maioria, convergindo com os anseios pontuados pelos participantes. A implantação do programa no âmbito universitário se mostrou relevante, haja vista que aumentou as possibilidades dos estudantes terem experiências com o lazer. Conclui-se que o programa pautou-se em princípios de participação popular, reconhecendo e acolhendo as indicações dos participantes na implementação.
Palavras-chaves:  Políticas Públicas; Esporte; Lazer; Acadêmicos.
Flipped Learning como alternativa pedagógica para el trabajo de la expresión musical en tiempos de pandemia (Flipped Learning as a pedagogical alternative for the work of musical expression in times of pandemic)
Authors: Pozo-Sánchez Santiago , Moreno-Guerrero Antonio-José , López-Núñez Juan-Antonio , López-Belmonte Jesús
Published: November 2022

La inclusión de la innovación metodológica es una realidad presente en la enseñanza en general. En esta tendencia hacia la optimización del proceso de enseñanza y aprendizaje se posiciona el modelo flipped learning o de aprendizaje invertido, un interesante recurso metodológico para la dinamización del aula. El presente estudio analiza la efectividad del flipped learning para el trabajo de la expresión musical, respecto a una metodología de formación tradicional. Para ello, se ha desarrollado un diseño cuasi-experimental en una muestra de 59 estudiantes de educación secundaria. Los resultados obtenidos reflejan que el uso de un método tradicional o del modelo de aprendizaje invertido genera resultados variables y cambios significativos en cada una de las dimensiones analizadas: interacciones, acceso a los contenidos, autonomía, colaboración, profundización, resolución de problemas, aprovechamiento del tiempo de clase y calificaciones. Se concluye que el aprendizaje invertido influye positivamente en diversas dimensiones socioeducativas, lo que permite una optimización del proceso de enseñanza y aprendizaje y una interesante herramienta para la innovación en la didáctica de la música.
Palabras clave: Educación tecnológica; expresión musical; innovación instruccional; aprendizaje invertido; diseño cuasi-experimental.
Abstract. The inclusion of methodological innovation is a reality present in teaching in general. In this trend towards the optimization of the teaching and learning process, the flipped learning or inverted learning model is positioned, an interesting methodological resource for the dynamization of the classroom. This study analyzes the effectiveness of flipped learning for the work of musical expression, compared to a traditional training methodology. For this, a quasi-experimental design has been developed in a sample of 59 secondary school students. The results obtained reflect that the use of a traditional method or the flipped learning model generates variable results and significant changes in each of the dimensions analyzed: interactions, access to content, autonomy, collaboration, deepening, problem solving, use of class time and grades. It is concluded that flipped learning has a positive influence on various socio-educational dimensions, which allows optimization of the teaching and learning process and is an interesting tool for innovation in music teaching.
Keywords: Technological education; musical expression; instructional innovation; flipped learning; quasi-experimental design.
Model Alternatif Wakaf Uang dalam Pemberdayaan Disabilitas (AWUPD)
Authors: Jihan Nabila Zahara  , Munifatussa’idah Asma’
Published: November 2022

Penelitian ini bertujuan untuk mengajukan model wakaf uang sebagai alternatif pemberdayaan penyandang disabilitas (AWUPD), dengan harapan pemanfaatan nilai manfaat aset wakaf uang mampu dikembangkan sebagai dana pelatihan (training) sumber daya manusia bagi penyandang disabilitas. Penelitian ini merupakan penelitian konseptual wakaf uang dan pemberdayaan disabilitas, menggunakan pendekatan kualitatif dengan metode analisis isi (content analyis). Hasil penelitian model AWUPD dirumuskan khusus untuk pemberdayaan disabilitas dengan penyediaan fasilitas program pelatihan dan pengembangan sumber daya manusia, yang bersumber dari nilai manfaat wakaf uang, berupa program pelatihan kemampuan dan keterampilan dalam mempersiapkan para disabilitas siap kerja di sektor formal. Dan program pelatihan kewirausahaan untuk mempersiapkan para disabilitas siap kerja di sektor informal. Implikasi penelitian ini diharapkan akan memberikan manfaat bagi Nazhir wakaf uang dalam pendistribusian nilai manfaat wakaf uang, penyandang disabilitas di Indonesia, serta Lembaga Kesejahteraan Sosial dan Dinas Sosial yang bertugas dalam perlindungan dan pemberdayan disabilitas.
Manajemen Cash Waqf sebagai Instrumen Alternatif SDG-1 "Ending Poverty" di Indonesia
Authors: Eugenia Syaima , Paramita Elvina Dian , Nurrahmah Nisa , Beik Irfan Syauqi
Published: November 2022

Memasuki era Sustainable Development Goals (SDGs) kemiskinan menjadi permasalahan yang belum dapat diselesaikan dan menjadi prioritas utama. Indonesia merupakan negara berkembang yang memiliki banyak permasalahan terkait kemiskinan. Jumlah populasi muslim di Indonesia yang terbesar di dunia menjadi salah satu alasan yang menunjukkan bahwa kemiskinan di Indonesia dapat diatasi melalui program wakaf uang secara produktif. Namun, saat ini potensi wakaf uang belum dikembangkan secara optimal. Penelitian ini bertujuan untuk menganalisis model pengelolaan wakaf uang di Indonesia dan merumuskan strategi pemanfaatan wakaf uang untuk mengentaskan kemiskinan di Indonesia. Metode yang digunakan adalah ANP-SWOT melalui studi literatur dan wawancara dengan pakar dan praktisi untuk memvalidasi hasil SWOT dan menentukan urutan prioritas. Hasil penelitian menunjukkan bahwa strategi-strategi yang perlu dilakukan berdasarkan urutan prioritas, antara lain adalah peningkatan profesionalisme dan kompetensi nazhir, mengoptimalkan teknologi digital dalam  pendistribusian wakaf uang, memaksimalkan kerjasama dengan ulama, Ormas Islam, dunia usaha, dan lembaga pemerintahan dalam meningkatkan sosialisasi dan literasi wakaf uang, meningkatkan program pengelolaan wakaf produktif, membuat sistem pelaporan transparan, akuntabel, dan terintegrasi, mengoptimalkan pemanfaatan teknologi digital dalam mendokumentasikan akta ikrar wakaf, regulasi yang memperkuat pendayagunaan wakaf uang dalam program ekonomi produktif, dan menginvestasikan wakaf uang pada portofolio investasi yang mampu memberikan margin yang tinggi dengan risiko yang dapat dimitigasi dengan baik.

Kata Kunci: ANP-SWOT, nazhir, pengentasan kemiskinan, wakaf produktif, wakaf uang.
Analisis Faktor-Faktor Yang Mempengaruhi Minat Wakif Dalam Berwakaf Pada Cash Waqf Linked Sukuk (CWLS) Dengan Altruisme Sebagai Variabel Moderasi
Authors: Afandi Ahmad , Harahap Darwis , Lubis Maisarah
Published: November 2022

Penelitian ini bertujuan untuk melihat pengaruh pengetahuan, media informasi, religiusitas terhadap minat wakif dalam berwakaf di Cash Waqf Linked Sukuk. Kemudian peneliti menambahkan variabel altruisme sebagai variabel moderasi. Jenis penelitian ini adalah penelitian kuantitatif deskriftif dan pengumpulan data menggunakan teknik kuisioner yang dibagikan kepada responden. Metode penentuan sampel dengan menggunakan rumus slovin didapat 100 responden penelitian. Teknik analisis data menggunakan Structural Equation Modeling (SEM) dengan bantuan SmartPLS. Penelitian menunjukan bahwa variabel pengetahuan, media informasi, religiusitas dan altruisme berpengaruh positif terhadap minat wakif dalam berwakaf di Cash Waqf Linked Sukuk. Kemudian untuk variabel altruisme tidak dapat memoderasi pengetahuan, media informasi dan religiusitas terhadap minat wakif dalam berwakaf di Cash Waqf Linked. Hasil penelitian ini diharapkan dapat dimanfaatkan menjadi sumber informasi dan referensi bagi pihak yang membutuhkan khususnya Badan Wakaf Indonesia (BWI).
Model Inkubasi Bisnis UMKM Berbasis Wakaf Uang Dengan Skema Akad Musyarakah
Authors: Zamahsyari Mohamad Ainun Najib
Published: November 2022

Penelitian ini menjelaskan model pemberdayaan masyarakat melalui integrasi UMKM dan nadzir dalam memanfaatkan dana wakaf dan pembagian produktifitas hasil usaha yang merata dengan kerja sama akad Musyarakah. Metode penelitian yang digunakan adalah metode kualitatif dengan memberikan model atau kerangka konseptual dan sumber data yang digunakan yaitu data sekunder melalui Sistematic Literatur Review, artikel ilmiah, dan hasil survei yang dilakukan oleh lembaga-lembaga pemerintah maupun swasta dengan objek yang berfokus pada wakaf tunai sebagai permodalan untuk mengembangan Bisnis UMKM dengan skema Akad Musyarakah. Penelitian ini dapat dijadikan sebagai bahan improviasi dan inovasi model penyaluran hasil investasi dana wakaf uang melalui program inkubasi bisnis dengan skema akad musyarakah sebagai hasil nisbah bagi setiap yang terlibat dalam pengelolaan bisnis dan penyalur wakaf tunai.

Kata Kunci: Inkubasi Bisnis, Akad Musyarakah, Wakaf Tunai
ANALYSIS OF HEAT TRANSFER ENHANCEMENT IN TUBES WITH CAPSULE DIMPLED SURFACES AND AL2O3-WATER NANOFLUID
Authors: ÖZGİRGİN YAPICI Ekin , IBRAHİM Mahmoud Awni A. Haj , TÜRKOĞLU Haşmet
Published: November 2022

This study aims to numerically investigate and evaluate the enhancement of heat transfer by new capsule dimples on tube surfaces for flow of water and Al2O3-water nanofluid with different concentrations, under uniform surface heat flux. The originality of this work lies in combining two passive heat transfer enhancement methods such as geometrical improvements and nanofluids together. Capsule dimples with different depths were considered. Al2O3-water nanofluid was modeled as a single-phase flow based on the mixture properties. The effects of dimple depth and nanoparticle concentrations on Nusselt number, friction factor and performance evaluation criteria (PEC) were studied. Numerical computations were performed using ANSYS Fluent commercial software for 2000 14000 Reynolds number range. It was found that when laminar, transient and fully developed turbulent flow cases are considered, increase in the dimple depth increases the Nusselt number and friction factor for both pure water and Al2O3-water nanofluids cases. Also, the friction factor increases as dimple depth increases. Results show that increase in PEC is more pronounced in the laminar region than in the transition region, it starts to decrease for turbulent flows. For nanofluid, PEC values are considerably higher than pure water cases. The variation of PEC for capsule dimpled tubes are dependent on flow regimes and dimple depths. Increasing the nano particle volume concentration and dimple depth in laminar flows increase the PEC significantly.
GENETIC POLYMORPHISM AND COLORECTAL CANCER
Authors:   Ryazan State Medical University, Sudakov A. I. , Kulikov E. P. ,   Ryazan State Medical University, Mertsalov S. A. ,   Ryazan State Medical University, Nikiforov A. A. ,   Ryazan State Medical University, Grigorenko V. A. ,   Ryazan State Medical University
Published: November 2022

The article analyzes the relationship of polymorphism of a number of genes with some features of colorectal cancer, such as the aggressiveness of its course and development of the disease, the effectiveness of preoperative chemoradiotherapy. The data obtained can be used to deter-mine individual tactics for treating patients.
DEVELOPMENT AND FUNCTION OF THE ADRENAL MEDULLA IN EXPOSED TO ENDOCRINE DISRUPTOR DDT ORGANISMS
Authors:   A.P. Avtsyn Research Institute of Human Morphology of FSBSI “Petrovsky NRCS”, Yaglova N. V.
Published: November 2022

Development and function of the adrenal medulla in exposed to endocrine disruptor DDT organisms was studied. The investigation revealed disrupted by DDT morphogenesis and se-cretion of adrenal medulla resulted in decreased production of catecholamines.
«STRUCTURE – ACTIVITY» RELATIONSHIP OF ANTIARRHYTHMIC DRUGS NIBENTAN AND NIFERIDYL
Authors:   A. N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences (INEOS RAS), Davydova N.K.
Published: November 2022

The paper summarizes data on the relationship between the chemical structure of nibentan and niferidyl pharmaceutical ingredients and their antiarrhythmic activity.
CORRELATION ANALYSIS OF THE MAIN BIOCHEMICAL MARKERS OF IN-FLAMMATION IN COVID-19
Authors:   Kuban State University, Zolotavina M. L. , Gaidabura E. A. ,   Kuban State University
Published: November 2022

The article is devoted to determining the correlation between the biochemical parameters of the blood serum of patients with COVID-19. Concentrations of the main biochemical markers of inflammation at different stages of lung tissue damage by a new coronavirus infection with further correlation analysis of blood parameters were determined. The experiment of the study showed that there is a high correlation between the biochemical parameters of blood. Its sig-nificance helps to determine the sequence of the manifestation of biochemical markers of in-flammation and proves the mechanism of changes in the biochemical picture of blood in COVID-19, which we assume.
IDENTIFICATION OF GRANULAR SALMON CAVIAR USING THE KJELDAHL METHOD
Authors:   Russian Federal Research Institute of Fisheries & Oceanography, Abramova L.S. , Kozin A. V. ,   Russian Federal Research Institute of Fisheries & Oceanography, Guseva E. S. ,   Russian Federal Research Institute of Fisheries & Oceanography, Gavrilov A. F ,   Russian Federal Research Institute of Fisheries & Oceanography
Published: November 2022

The paper discusses the problem of determining the authenticity of granular salmon caviar by substantiating methodological approaches to quantifying the quality and using the results to compare the characteristics of the object under study with the regulated characteristics of the indicators of natural salmon caviar, chum salmon, sockeye salmon and coho salmon.
MACROPHAGES AND TRANSPLANTATION OF POLYLACTIDE FILM WITH XENOFIBROBLASTS INTO ISCHEMIC CUTANEOUS WOUND
Authors:   V.I. Vernadsky Crimean Federal University, Boyko T. A. , Shapovalova Y. Y. ,   V.I. Vernadsky Crimean Federal University, Baranovskiy Y. G. ,   V.I. Vernadsky Crimean Federal University, Harchenko S. V. ,   V.I. Vernadsky Crimean Federal University, Lugin I. A. ,   V.I. Vernadsky Crimean Federal University, Baranovskiy A. G. ,   V.I. Vernadsky Crimean Federal University
Published: November 2022

The paper discusses the presence of macrophages in biopsies of a healing model ischemic skin defect on the 12th day after intraoperative transplantation of a polylactide film with xenogenic dermal fibroblasts cultured on it. Original data are presented on the suitability of a polylactide film as a filler due to the absence of a rejection reaction and accelerated defect healing.
INTERFERENCE OF PRENATAL EXPOSURE TO ENDOCRINE DISRUPTOR DDT WITH DEVELOPMENT OF IMMUNE ORGANS
Authors:   A.P. Avtsyn Research Institute of Human Morphology of FSBSI «Petrovsky NRCS», Gagulaeva B. B. , Obernikhin S. S. ,   A.P. Avtsyn Research Institute of Human Morphology of FSBSI «Petrovsky NRCS», Timokhina E. P. ,   A.P. Avtsyn Research Institute of Human Morphology of FSBSI «Petrovsky NRCS», Yaglova N. V. ,   A.P. Avtsyn Research Institute of Human Morphology of FSBSI «Petrovsky NRCS»
Published: November 2022

Development of central and peripheral organs of immune defense in newborn rats that devel-oped under the influence of the endocrine disruptor DDT was studied. Exposure to DDT dur-ing the prenatal period was found to change the rates of development of the thymus and spleen.
FALSE POSITIVE DIAGNOSIS OF CHROMOSOMAL MOSAICISM IN IVF: FACTORS OF INFLUENCE
Authors:   Lomonosov Moscow State University, Ivanova A.D. , Tofilo M. A. ,   Laboratory Medical Genomics, Volodyaev I. V. ,   Lomonosov Moscow State University,   European Medical Center
Published: November 2022

The article discusses the influence of laboratory factors on the occurrence of artifact noise on NGS profiles, which can be falsely interpreted as chromosomal mosaicism of preimplantation embryos in IVF clinical practice.
IMPACT OF IMPAIRED CANONICAL WNT SIGNALING TO DISMORPHOGENE-SIS OF THE ADRENALS INDUCED BY ENDOCRINE DISRUPTOR DDT
Authors:   A.P. Avtsyn Research Institute of Human Morphology of FSBSI “Petrovsky NRCS”, Tsomartova D. A. ,   Federal State Autonomous Educa-tional Institution of Higher Education I.M. Sechenov First Mos-cow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Yaglova N. V. ,   A.P. Avtsyn Research Institute of Human Morphology of FSBSI “Petrovsky NRCS”, Obernikhin S. S. ,   A.P. Avtsyn Research Institute of Human Morphology of FSBSI “Petrovsky NRCS”, Ivanova M. Y. ,   Federal State Autonomous Educa-tional Institution of Higher Education I.M. Sechenov First Mos-cow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Chereshneva E. V. ,   Federal State Autonomous Educa-tional Institution of Higher Education I.M. Sechenov First Mos-cow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Published: November 2022

Development of the adrenal cortex in prenatally and postnatally exposed to endocrine disrup-tor DDT rats was studied. Inhibition of Wnt signaling was found in all the three cortical zones. The findings indicate that dismorphogenesis of the adrenal cortex is associated with impaired Wnt signaling and also suggest that DDT disrupts transcriptional regulation of morphogenetic processes in the adrenals.
IMPACT OF COVID-19 OF ON NEUROGENESIS IN THE ADULT BRAIN
Authors:   Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences” (ICB RAS), Zhdanova D. Y. , Chaplygina A. V. ,   Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences” (ICB RAS), Kovalev V. I. ,   Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences” (ICB RAS), Bobkova N. V. ,   Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences” (ICB RAS)
Published: November 2022

The recent outbreak of the novel coronavirus disease (COVID-19) has resulted in a huge num-ber of infected patients worldwide. This article provides a brief overview of the current state of the problem of the neurological consequences of COVID-19 caused by impaired neurogen-esis in the adult brain under the influence of the RNA-containing SARS‑CoV‑2 virus. The reported study was funded by RSF № 18-15-00392.
EFFECT OF RHAPONTICUM CARTHAMOIDES AND CRANBERRY MEAL EX-TRACTS COMPOSITION ON RATS HEART
Authors:   Novosibirsk Institute of Organic Chemistry, Khalikova D. A. , Ankov S. V. ,   Novosibirsk Institute of Organic Chemistry, Meshkova J. V. ,   Novosibirsk Institute of Organic Chemistry, Zhukova N. A. ,   Novosibirsk Institute of Organic Chemistry, Tolstikova T. G. ,   Novosibirsk Institute of Organic Chemistry
Published: November 2022

The article investigates the effect of Rhaponticum carthamoides and cranberry meal extracts composition at a dose of 70:500 mg/kg on electrocardiogram parameters, as well as structural and functional changes in the heart of female Wistar stock rats with prolonged administration (28 days).
ANALYSIS OF MORPHOLOGICAL CHANGES OF TESTES AFTER γ- IRRADIA-TION
Authors:   Polessky State University, Al Meselmani M.A. , Glinskaya N.A. ,   Polessky State University
Published: November 2022

We studied the effects of radiation in small doses (0.5 Gy) on the spermatogenic epithelium of white rats, counted the number of transversely cut convoluted seminiferous tubules, and de-termined the types of tubules. A decrease in the number of seminiferous tubules was noted, with damage to the cells of the spermatogenic epithelium.
MEDICAL AND SOCIAL PROBLEMS OF DISABILITY
Authors:   Kuban State Medical University, Akhedzhak-Naguze S. K. , Naguze A. A. ,   SCF FSBEI VO "RGUP"
Published: November 2022

The presented work reflects the main current data on medical and social problems of disability in the region. The authors analyzed the indicators of primary and repeated disability of the adult population of the Krasnodar Territory. The article puts forward proposals for optimizing rehabilitation and habilitation measures for this category of the population.
MEDICAL AND SOCIAL ASPECTS AFFECTING THE MORBIDITY OF MEDICAL UNIVERSITY STUDENTS
Authors:   Kuban State Medical University, Akhedzhak-Naguze S. K. , Romantsov V. V. ,   Kuban State Medical University, Popov Z. S. ,   Kuban State Medical University, Naguze A. A. ,   SCF FSBEI VO "RGUP"
Published: November 2022

The presented work presents basic data on the availability of medical services that affect the level of health of students in medical higher educational institutions. The authors reflect the relationship of the considered problems and the development of somatic anthologies among student youth. The article puts forward proposals for optimizing the process of improving the social group of the population.
POLYPHASE APPROACH FOR SPECIES IDENTIFICATION OF MICROMY-CETES - FOOD CONTAMINANTS
Authors:   Federal Research Centre of Nutrition and Biotechnology, Minaeva L. P. , Markova Y. ,   Federal Research Centre of Nutrition and Biotechnology, Evsjukova A. D. ,   Federal Research Centre of Nutrition and Biotechnology
Published: November 2022

The article presents an integrated approach based on polyphasic taxonomy, which includes the study of phenotypic, molecular genetic and chemotaxonomic characteristics of micromycetes. This approach makes it possible to obtain reliable results of species identification of mold con-taminants in food products, to expand knowledge about the metabolite profiles of specific fungal species and their chemotypes. The potential for the formation of mycotoxins (MT) by mold con-taminants of the genus Aspergillus isolated from coffee raw materials has been shown. It was shown that, under favorable conditions, they are able to simultaneously accumulate several dangerous MTs (OTA, AFL B1, FB2), as well as emergent MT (STC).
THE CYTOLOGICAL EXAMINATION IN THE DIAGNOSTICS OF NON-TUMOR LESIONS AND OVARIAN TUMORS.
Authors:   Russian Medical Academy of Continuous Professional Education of the Ministry of Health, Karpova A.E. , Sozaeva L.G. ,   Russian Medical Academy of Continuous Professional Education of the Ministry of Health, Shabalova I.P ,   Russian Medical Academy of Continuous Professional Education of the Ministry of Health
Published: November 2022

Determination of the significance of conventional cytology, liquid-based cytology and im-munocytochemical studies in the diagnosis of non-tumor lesions and ovarian tumors.
DINITROSYL IRON COMPLEXES PROTECT HEMOGLOBIN FROM OXIDATION
Authors:   Federal Research Center of Biotechnology, Kosmachevskaya O. V. , Nasybullina E. I. ,   Federal Research Center of Biotechnology, Pugachenko I. S. ,   Federal Research Center of Biotechnology, Shumaev K. B. ,   Federal Research Center of Biotechnology, Novikova N. N. ,   Kurchatov Institute, Topunov A. F. ,   Federal Research Center of Biotechnology
Published: November 2022

Hemoglobin-bound dinitrosyl iron complexes (Hb-DNICs) are dose-dependently degraded by peroxynitrite. At the same time, they protect Hb from oxidative modification: they prevent the formation of carbonyl derivatives, the oxidation of tryptophan residues, the degradation of the heme group, and the formation of crosslinks between subunits.
CARBONYL STRESS IN BACTERIA. ANTI-GLYCATION EFFECT OF NITROXYL ON ESCHERICHIA COLI CELLS
Authors:   Federal Research Center of Biotechnology, Nasybullina E.I. , Pugachenko I. S. ,   Federal Research Center of Biotechnology, Kosmachevskaya O. V. ,   Federal Research Center of Biotechnology, Topunov A. F. ,   Federal Research Center of Biotechnology
Published: November 2022

Bacteria suffer carbonyl stress at sudden transition to high-level carbohydrate substrates or in a stationary phase. Methylglyoxal (MG) inhibited bacterial growth and increased advanced glycation end products. Nitroxyl prevented the toxic effect of MG in a low-aerated cell culture.
EFFECT OF NITROXYL ON MODIFICATION OF HEMOGLOBIN BY OXIDATION AND GLYCATION
Authors:   Federal Research Center of Biotechnology, Pugachenko I.S. , Nasybullina E. I. ,   Federal Research Center of Biotechnology, Kosmachevskaya O. V. ,   Federal Research Center of Biotechnology, Topunov A. F. ,   Federal Research Center of Biotechnology
Published: November 2022

Nitroxyl in biological systems can work as a classic antioxidant. It has been shown that ni-troxyl reduces the yield of free radical products in the reaction of hemoglobin with tert-butyl peroxide. Due to this, nitroxyl slows down the formation of non-enzymatic glycation products in the reaction of hemoglobin with methylglyoxal.
rs652438 POLYMORPHISM OF THE MMP-12 GENE AND ANALYSIS OF DEGREE OF OXIDATIVE DAMAGE TO GENOMIC DNA
Authors:   Kuban State University, Tekutskaya E. E. , Pavlyuchenko I. I. ,   Kuban State Medical University, Gusaruk L. R. ,   Kuban State Medical University
Published: November 2022

The article provides a comparative analysis of the degree of oxidative DNA damage in epi-dermolysis bullosa (EB) and bronchial asthma (BA). It was found that the concentration of the modified base 8-oxoguanine in patients with BE is 1.9 times higher than in the control group. Different concentrations of 8-oxoguanine in BE and BE indicate the severity of struc-tural DNA damage in BE and the almost absence of oxidative modification of DNA in AD.
INFLUENCE OF ENVIRONMENTAL PARAMETERS ON THE STABILITY OF THE DNA MOLECULE
Authors:   Kuban State University, Bezhenar M. V. ,   SSC RAS, Drobotenko M. I. ,   Kuban State University, Svidlov A. A. ,   Kuban State University,   SSC RAS, Lyasota O. M. ,   Kuban State University, Tochenaya V. V. ,   Krasnodar Lyceum No. 4, Sulima A. O. ,   Krasnodar Lyceum No. 4
Published: November 2022

In the article, based on the numerical solution of a mechanical mathematical model of the interferon alpha 17 gene and a fragment of the drosophila gene, the influence of the viscosity of the external environment on the dynamics of the DNA molecule and its stability is analyzed. It is shown that an increase in viscosity leads to rapid stabilization of the angular oscillations of nitrogenous bases, and a decrease in viscosity changes the dynamics of DNA: the rate of change in the angular deviations of nitrogenous bases increases and the angular deformations of DNA strands increase at each moment of time.
STUDY OF THE EFFECTS OF NITRIC OXIDE ON FUNCTIONING P - GLYCOPROTEIN
Authors:   Ryazan State Medical University, Sudakova E. A. , Shchulkin A. V. ,   Ryazan State Medical University, Abalenikhina Y. V. ,   Ryazan State Medical University, Yakusheva E. N. ,   Ryazan State Medical University
Published: November 2022

The article talks about the effect of nitric oxide (NO) on the functioning of the P-glycoprotein (Pgp) transporter protein in Caco-2 cells. The NO donor is S-nitrosoglutathione (GSNO). When exposed to a specific inhibitor of soluble guanylate cyclase, an increase in the relative amount of Pgp was shown.
RELATIONSHIP OF DIET WITH IRON DEFICIENCY IN ATHLETES
Authors:   Federal State Budgetary Institution of Science Fed-eral Research Center for Nutrition, Biotechnology and Food Safety, Academy of Postgraduate Education of FSBI FNCC FMBA of Russia, Kobelkova I. V. , Korosteleva M. M. ,   Federal State Budgetary Institution of Science Fed-eral Research Center for Nutrition, Biotechnology and Food Safety,   Federal State Autonomous Educational Institution of Higher Professional Education «Peoples' Friendship University of Russia»
Published: November 2022

A short-term imbalance between increased needs for macro- and micronutrients and their actual intake can lead to rapid fatigue, which is expressed in a decrease in endurance and sports performance. The cause of these symptoms may be iron deficiency conditions, which are widespread among athletes. The study of the features of actual nutrition, the relationship between the consumption of meat and dairy products with the nutritional status and health status of athletes with a high and extremely high level of physical activity is very relevant.
EXPRESSED PLANT HEMOGLOBIN AS AN INGREDIENT FOR PRODUCTION OF «PLANT-BASED MEAT»
Authors:   Federal Research Center of Biotechnology, Topunov A. F. , Kosmachevskaya O. V. ,   Federal Research Center of Biotechnology, Nasybullina E. I. ,   Federal Research Center of Biotechnology
Published: November 2022

Escherichia coli cells with an embedded soybean leghemoglobin (Lb) gene produce this protein in a reduced oxygenated state. The cells synthesizing Lb turned out to be more sensitive to the action of oxidative and nitrosative stress inducers, than cells without Lb.
COVID-19 PANDEMIC DURING THE GLOBAL SOLAR MINIMUM: GENOGEOGRAPHY, LOCKDOWNS, VACCINATION
Authors:   Institute of Terrestrial Magnetism and Radio Wave Propagation, Russian Academy of Sciences, Ragulskaya M.
Published: November 2022

The COVID-19 pandemic started at the minimums of the 11-year solar cycle and quasi-secular solar cycle. Genetic population characteristics played a decisive role in the development of local coronavirus epidemics under the conditions of the solar activity global minimum. Their contribution is more than 500% against 20-30% accounted for by other factors (except for vaccination), such as the average age of the population, lockdowns, isolation of patients, weather conditions, and the level of medicine. In Europe, the incidence of COVID-19 per mil-lion people in the R1b:R1a:N haplogroups correlates as 7:2:1. This ratio is practically inde-pendent of the pandemic waves, new coronavirus strains and the level of population vaccina-tion.
PARTICIPATION OF NUCLEAR FACTOR OF ERYTHROID ORIGIN-2 IN REGU-LATION P-GLYCOPROTEIN IN MODELING ENDOGENOUS OXIDATIVE STRESS
Authors:   Ryazan State Medical University, Abalenikhina Y. V. , Seidkuliyeva A.A. ,   Ryazan State Medical University, Rokunov E. D. ,   Ryazan State Medical University, Nemtinov D.S. ,   Ryazan State Medical University, Shchulkin A. V. ,   Ryazan State Medical University, Yakusheva E. N. ,   Ryazan State Medical University
Published: November 2022

The article discusses the mechanisms of regulation of the P-glycoprotein transporter protein (Pgp) in cells of the Caco2 line under conditions of modeling endogenous oxidative stress caused by exposure to DL-butyonine sulfoximine (BSO, a glutathione synthesis inhibitor). Ex-periments have shown that exposure to BSO at concentrations of 10-100 μM leads to a de-crease in the concentration of glutathione, an increase in the amount of Pgp and nuclear factor of erythroid origin 2 (Nrf2). Inhibition of Nrf2 contributed to the normalization of Pgp levels, which proves the participation of the transcription factor in the regulation of the transporter protein under the conditions of modeling endogenous oxidative stress.
GLOBIN COUPLED PHOTOBIOMODYLATION OF CHONDROCYTE SURFACE
Authors:   FRC ", Alexandrovskaya Y. M. ,   Crystallography and Photonics",   RAS, Baum O. I. ,   FRC "Crystallography and Photonics" RAS, Dmitriev A. K. ,   FRC "Crystallography and Photonics" RAS, Tiflova О. A. ,   FRC "Crystallography and Photonics" RAS
Published: November 2022

The possibility of photobiomodulation of the surface of rabbit chondrocytes under the action of laser radiation with the parameters appropriate for spectral and kinetic characteristics of guanylate cyclase via local overheating of the globin chromophore temporary associated with the caveolae of the membrane has been revealed.
Na,K-HOMEOSTASIS IN THE EPIDERMIS AS A PHENOMENON OF SELF-ORGANIZED CRITICALITY
Authors:   International Baltic Academy, Petukhov Valery I. , Dmitriev Egor V. ,   Institute of Computational Mathematics of the RAS
Published: November 2022

Using atomic emission spectrometry, the content of sodium (Na) and potassium (K) in the epidermal derivative (hair) was measured in healthy individuals (9991 people). According to the spectrometry data, 4 groups were formed depending on the Na/K ratio: group 1 - Na/K <1 (n=1834); 2nd - Na/K from 1 to 5 (n=6884); 3rd – Na/K from 5 to 10 (n=893) and 4th – Na/K >10 (n=380). A correlation analysis (Pearson) of the tightness of the K-Na connection was carried out in the total sample (n=9991) and in each of the groups with different Na/K values. It was found that the correlation coefficient r in the total sample (r K-Na = 0.61; p<0.05) was noticeably lower than in any of the formed groups (r K-Na = 0.85-0.97; p <0.05). It was also established that the decrease in r K-Na was caused by the presence of spectrometry data with Na/K <1 (group 1) in the total sample.
NITRIC OXIDE DONORS IN CHEMOTHERAPY OF BRAIN TUMORS
Authors:   Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Sanina Nataliya A.
Published: November 2022

The paper presents theoretic and experimental data of studies of low-molecular-weight iron dinitrosyl complexes as nitric oxide (NO) donors with selective toxicity to brain tumors.
NEUROLOGICAL DISORDERS AND OTHER KNOWN PATHOLOGIES DUE TO NITRIC OXIDE AND SUPEROXIDE CYCLING DISTURBANCES
Authors:   Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Reutov V. P. , Sorokina E. G. ,   «National Medical Research Center for Children's Health», Russian Ministry of Health
Published: November 2022

The article discusses the mechanisms of development of a typical pathological process, oxi-dative and nitrosative stress, which underlie many neurological disorders and other known diseases. Cycles of nitric oxide and superoxide anion-radical under physiological conditions do not allow the development of pathological changes in the vital systems of the body. How-ever, when they are damaged, the main regulatory mechanisms are violated, and “dysregula-tory pathology” sets in (G.N. Kryzhanovsky), due to the formation of extremely active com-pounds - nitrogen dioxide (NO2), OH-radicals and peroxynitrites, which, after protonation, decompose again with the formation of radicals NO2 and OH radicals. It is hypothesized that it is these mechanisms that disrupt the cycles of nitric oxide and the superoxide anion radical that underlie the development of a typical pathological process.
ADAPTIVE FEATURES OF ADIPOSE TISSUE FORMATION IN PIGS OF THE COMMERCIAL DUROC BREED AND THE SEARCH FOR GENES UNDER SELEC-TION PRESSURE
Authors:   V. M. Gorbatov Federal Research Center for Food Systems, Kotenkova E. A. , Pchelkina V. A. ,   V. M. Gorbatov Federal Research Center for Food Systems, Chernukha I. M. ,   V. M. Gorbatov Federal Research Center for Food Systems
Published: November 2022

The paper discusses the results of histological analysis of fat samples of various localization obtained from Duroc pigs. The presence of atypical adipocytes in certain localities was found, which contributes to the understanding of the processes of adaptive thermogenesis in pigs. Ge-netic analysis showed the presence of a number of genes involved in adipogenesis, the formation of qualitative characteristics in meat raw materials and adaptation to climatic conditions, in-cluding extreme ones.
MODIFIED ALBUMIN AS AN INDICATOR OF OXIDATIVE STRESS IN ISCHEMIC-HYPOXIC INJURIES OF THE BRAIN AND VARIOUS ORGANS
Authors:   «National Medical Research Center for Children's Health», Russian Ministry of Health, Sorokina E.G. , Karaseva O. V. ,   Research Institute of Emergency Pediatric Surgery and Traumatology, Afanasyeva S.A. ,   «Scientific Medical Research Center for Children's Health", Globa O. V. ,   «Scientific Medical Research Center for Children's Health", Semenova Z. B. ,   Research Institute of Emergency Pediatric Surgery and Traumatology, Reutov V. P. ,   Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Pinelis V. G. ,   «Scientific Medical Research Center for Children's Health", Russian Ministry of Health
Published: November 2022

The article discusses the literature data on the relationship of modified albumin by ishemia (IMA) and nitrosative stress (nitroalbumin/nitrotyrosine) to the ischemic/hypoxic damage of the brain and other organs. Data on the association of an increase in the content of IMA with a violation of the binding of serum albumin of metals, which is observed in processes accompanied by oxidative oxygen and nitrosative stress, are presented.
METABOLITES OF NITROGEN OXIDE AMONG PATIENTS WITH DISTURBANCE OF REPRODUCTIVE FUNCTION
Authors:   Ryazan State Medical University, Ishtulin Artem F. , Korotkova Natalya V. ,   Ryazan State Medical University, Matveeva Irina V. ,   Ryazan State Medical University, Minaev Ivan V. ,   Ryazan State Medical University, Polyakova Polina M. ,   Ryazan State Medical University
Published: November 2022

This article presents the results of an exploration of the determination of nitrogen oxide me-tabolites in spermoplasm among patients with chronic prostatitis IIIB with asthenozoospermia and patients with varicocele of II and III stages with asthenozoospermia.
INVESTIGATION OF THE POSSIBILITY OF CREATING F CATHETER FIBEROPTIC SENSOR FOR INVASIVE MEASUREMENT OF LOW PRESSURES IN THE DIAGNOSIS OF THE PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL STATE OF THE HUMAN BODY
Authors:   Penza State University, Badeeva E. A. , Murashkina T. I. ,   Penza State University, Gerashchenko S. I. ,   Penza State University, Serebryakov D. I. ,   JSC «Research Institute of Physical Measurements», Badeev V. A. ,   Penza State University, Parshikova T. V. ,   Penza State University
Published: November 2022

The problematic issues that arise when measuring low pressures in the diagnosis of the phys-iological and pathophysiological state of the human body and the associated difficulties in designing measuring instruments are considered. It is proposed to use a fiber-optic low pressure sensor located in a narrow catheter. The deflection of a Teflon membrane with small dimensions and stable elasticity of the material is calculated, providing the required sensitivity of the optical signal conversion in the pressure measurement range 0...100 mm Hg.
PROBLEMATIC ISSUES OF THE USE OF FIBER-OPTIC PRESSURE SENSORS IN MEDICAL PRACTICE
Authors:   Penza State University, Murashkina T. I. , Badеeva E. A. ,   LLC "Special fiber-optic measuring system", Ayupova F. S. ,   Kuban state medical University, Vasiliev Y. A. ,   Kuban state medical University, Ponomarenko T. V. ,   Kuban state medical University, Parshikova T.V. ,   LLC "Special fiber-optic measuring system"
Published: November 2022

The article proposes to accurately measure the pressure of the tongue on the palate to intro-duce an additional element into the design of a fiber-optic pressure sensor, the profile and dimensions of which repeat the profile and dimensions of the patient's palate. For its rapid and high-quality manufacture, it is proposed to determine the distance to individual points of the sky by changing the reflected light flux from the sky using an original device, which is a platform with runners on which a fiber-optic sensor element moves.
FEATURES OF BREASTFEEDING AND ARTIFICIAL FEEDING OF NEWBORNS OF THE PERINATAL PERIOD
Authors:   GBUZ Maternity Hospital of Krasnodar, Plotnikova E.Y. , Badeeva E.A. ,   Penza State University, Murashkina T. I. ,   Penza State University, Lonteva A. N. ,   GBUZ Maternity Hospital of Krasnodar, Fomenko A.G. ,   GBUZ Maternity Hospital of Krasnodar, Shapovalova E. L. ,   GBUZ Maternity Hospital of Krasnodar, Davydenko E. G. ,   GBUZ Maternity Hospital of Krasnodar, Kochetkova E.S. ,   GBUZ Maternity Hospital of Krasnodar, Olenskay A. V. ,   Kuban State Medical University
Published: November 2022

The interrelation of anatomical and physiological features of the language during breastfeed-ing and artificial feeding with the strength of its pressure is considered. The introduction of fiber-optic diagnostics of the pressure force of the newborn's tongue, as it will facilitate the selection of the optimal diameter of the nipple outlet during artificial feeding of the child with an untenable sucking reflex.
EXCEL ADD-INS IN MEDICAL INFORMATICS TRAINING COURSES
Authors:   Kuban State Medical University, Zobenko V. Y. , Olenskaya A. V. ,   Kuban State Medical University, Vasiliev Y. A. ,   Kuban State Medical University
Published: November 2022

The article examines the experience of using various add-ons for Excel in the educational process with medical students. Such add-on applications as "Analysis Package", "AtteStat", "Solution Search" are being analyzed.
PROTON BEAM THERAPY CENTER AT NRC "KURCHATOV INSTITUTE", MOSCOW
Authors:   National Research Center «Kurchatov Institute», Bulatov M. S. , Zhidkov D. A. ,   National Research Center «Kurchatov Institute», Klenov G. I. ,   National Research Center «Kurchatov Institute», Khoroshkov V. S. ,   National Research Center «Kurchatov Institute», Chernykh A. N. ,   National Research Center «Kurchatov Institute»
Published: November 2022

In March 2020, the Government of the Russian Federation approved the Federal Scientific and Technical Program for the Development of Synchrotron and Neutron Research and Re-search Infrastructure for 2019–2027 (FSTP). In accordance with the Decree, the Federal State Budgetary Institution “National Research Center “Kurchatov Institute” (NRC “Kur-chatov Institute”) is designated as the lead scientific organization of the Program. The program provides for the development and launch at the National Research Center "Kur-chatov Institute" of the Proton Beam Therapy Complex for long-term multi-year development of new generations of PBT facilities and technologies, training of personnel (medical physi-cists and clinicians, treatment of a limited number of cancer patients and clinical trials). The complex of proton beam therapy will include two treatment rooms, one room with a rotating proton beam rotation system - gantry and one with a fixed beam. A synchrotron with a maxi-mum energy of 250 MeV will supply each treatment room with proton beams. The beam energy can vary from 70 to 250 MeV directly in the process of proton acceleration. The features of the developed proton beam therapy system are compared with other systems. Currently, the development of all non-standardized equipment of the complex being created is underway. The building is being designed, construction should begin in 2023. The calculation of radia-tion-protective walls has been analytically performed, a more detailed calculation is being carried out.
DETERMINATION OF THE PULSE WAVE PROPAGATION VELOCITY DURING NONINVASIVE ASSESSMENT OF THE STATE OF THE CARDIOVASCULAR SYSTEM USING PRECISION FIBEROPTIC MICRODISPLACEMENT SENSORS
Authors:   LLC ", Murashkina T. I. ,   Special fiber-optic measuring systems", Gerashchenko S. I. ,   Penza State University, Badeeva E.A. ,   Penza State University, Badeev A. V. ,   Penza State University, Gerashchenko M. S. ,   Penza State University
Published: November 2022

The problematic issues arising from the non-invasive measurement of the pulse wave velocity of blood flow, an important prognostic parameter of cardiovascular diseases, and the associ-ated difficulties in designing measuring instruments, first of all, the low reliability and accu-racy of measurement of known photoplethysmographic measuring and diagnostic tools, lead-ing to an increase in the components of the basic error, the overall dimensions of the devices, the use of indirect measurement methods entailing large methodological measurement errors. It is proposed to switch to advanced fiber-optic micro-displacement sensors and new methods of measuring the pulse wave velocity of blood flow with their help.`
SIMULATION OF LASER-INDUCED COAGULATION OF TUMOR TISSUE
Authors:   IPT FRC “Crystallography and Photonics” RAS, Dmitriev A. K. , Kortunov V. N. ,   IPT FRC “Crystallography and Photonics” RAS, Ulyanov V. A. ,   IPT FRC “Crystallography and Photonics” RAS
Published: November 2022

To investigation the processes of laser-induced coagulation of tumor tissues in relation to the problem of treating hepatocellular carcinoma, a biomodel based on chicken egg protein is proposed. The possibility of effective formation of a 3D temperature region in the volume of tumor tissue by delivering laser radiation by optical fibers is shown.
HEMISPHERIC FEATURES OF EEG PATHOLOGICAL PATTERNS IN CASE OF DAMAGE TO THE REGULATORY STRUCTURES OF THE HUMAN BRAIN.
Authors:   IHNA& NPh RAS, N.N.Burdenko NSPCN, Boldyreva G.N.
Published: November 2022

A generalization of the results of the analysis of the electrical activity of the brain of patients with tumor lesions of diencephalic and limbic structures made it possible to replenish the set of diagnostic EEG signs of damage to regulatory structures and expand the clinic's accepted interpretation of interhemispheric asymmetry of EEG in cerebral pathology.