bluuebunny/crossref_metadata_2025 huggingface dataset:
Quercetin Nano-formulations as a Potential Approach for Skin Cancer
Authors: Kapare Harshad , Kanadje Sunil , Bhole Ritesh
Published: December 2024

Quercetin, a natural flavonoid, is well-proven for anticancer properties in a variety of
cancers. Quercetin's anticancer action is driven by its anti-inflammatory and antioxidant properties.
It inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-6) and suppresses NF-κB and COX-2,
reducing tumor growth. Its antioxidant activity neutralizes reactive oxygen species (ROS), preventing
oxidative damage that can lead to cancer. However, quercetin faces challenges such as poor
solubility, bioavailability, instability, low skin penetration, rapid metabolism, and potential systemic
toxicity at high doses, which limit its therapeutic application. Nanocarrier systems such as liposomes,
polymeric nanoparticles (PLGA-based), solid lipid nanoparticles (SLNs), and nanoemulsions
have been developed to address these issues. These formulations enhance quercetin’s penetration,
stability, and bioavailability, improving its effectiveness against skin cancers by promoting
controlled release and targeted delivery. Nanocarriers offer a promising solution to overcome
these limitations and enhance its anticancer potential.
Formulation and Assessment of an Optimized Glimepiride Transdermal Therapeutic System Using 32 Full Factorial Design Approach
Authors: Mali Audumbar , Mali Sunayana
Published: December 2024

Background:

Currently, a large number of populations are suffering from diabetes mellitus,
which significantly increases the burden on public health. Glimepiride is an antidiabetic drug
with a shorter half-life (approximately 5 hours), low bioavailability, and first-pass metabolism. Due
to these limitations, it is required to maintain a uniform therapeutic level, and it has been chosen as
a transdermal drug delivery approach.

Objectives:

The main objective of this investigation was to evaluate glimepiride-loaded transdermal
patches on the skin to treat diabetes mellitus. To overcome the issue of oral glimepiride and provide
a localized effect, a transdermal drug delivery approach was developed.

Methods:

The glimepiride transdermal drug delivery approach was developed by using the solvent
evaporation method. To examine the impact of altering amounts of polyvinyl alcohol (X1) and polyvinyl
pyrrolidone (X2) on tensile strength, % of glimepiride released in 12 hours (Q12), and % of
glimepiride released in 24 hours (Q24), as reliant on variables, a 32 complete factorial design was
employed. For dependent variables, regression estimation and estimation of variance were employed.
In-vitro release statistics were fixed to different models for various glimepiride release kinetics.
In-vitro glimepiride release was tested using the best formulation.

Results:

The formulation F4 with 1300.00 milligrams of polyvinyl alcohol and 600.00 milligrams
of polyvinyl pyrrolidone demonstrated a release of 96.17% for up to 24 hours and zero order release
kinetics consisting of r2=0.987, which was the best batch. The optimized formulation F4 showed a
controlled release of glimepiride and better permeation and deposition properties.

Conclusion:

The findings of this research work demonstrated the potential of the 32 full factorial
mathematical models created to anticipate formulations with additional desirable release and permeability
qualities for the treatment of diabetes mellitus.
Impact of Contract Research Organizations on Pharmaceutical Industries: A Review
Authors: Solanki Neeta , Verma Jaya , Kumar Satyender , Seema  , Mundlia Jyoti , Saini Rajesh , Saini Sapna
Published: December 2024

Contract Research Organizations are bodies that offer research and development services
on a contract basis to the pharmaceutical, biotechnology, medical device, and other industries.
These organizations offer a wide range of services to support the drug discovery, development,
and commercialization process. Initially, CROs begin with clinical trial management
facilities and assisting sponsors with clinical study design, whereas laboratory CROs provide
drug discovery, manufacturing, and bioanalytical services, including site feasibility. Their services
mainly cover pharmaceutical and biotechnology industry based work such as drug development,
pharmaceutical product development, clinical and preclinical trials, analytical method
developments, pharmacovigilance, medical writing, etc. India presents itself as a wonderful
platform for CROs attributing to its huge population, varied disease conditions, accessible human
resources, large number of hospitals and low treatment cost. In the clinical trial process,
CROs are engaged by the sponsor to accomplish a number of duties, taking into account various
administrative and technical responsibilities on behalf of the sponsor. The current manuscript
highlights the globalization of clinical trials, the concept of CRO, roles and responsibilities,
functions of CROs, regulatory infrastructure of CRO, criteria for selection of suitable CRO,
Indian CRO market and impact of Covid-19 pandemic on it.
Normative Corporality Representation in the Muslim Media of Ural Region during the Covid-19 Pandemic (Through the Example of Khikmet and Khilyal Papers)
Authors:   Ural federal university named after the first President of Russia B.N. Yeltsin, Latyshev Dmitry Mikhailovich
Published: December 2024

A study of this topic is relevant in the context of “new normality” phenomena related to Covid-19 pandemic. The main and specific discursive productions of normative corporality are demonstrated through the examples from Khikmet and Khilyal papers published in Tyumen and Chelyabinsk ob-lasts. Some contradictions between recurrent narratives and emerging barriers in the adaptation to the new normality are also shown. Due to fact that Islamic anthropology gives primacy to medical knowledge, an emphasis was made on the high value of health and allowability of vaccination. The materials under study emphasize the development of personal qualities of Muslims necessary to overcome the disruption of social order. However, methods for improving mental health were not discussed.
Amidst the Euphoria of Digitalization Public Services in Municipal Government: Raising Public Acceptance
Authors: Wargadinata Ella Lesmanawaty , Tendean Noudy R. P.
Published: December 2024

Information and communication technology was used for two decades to elevate good governance practices under Indonesia’s bureaucratic reform policy. With the fast-expanding use of the internet, all government organizations are being pushed to implement digital public services to eliminate rigid procedures. This study aims to reveal factors affecting public perception’ and acceptance of digital public services using a qualitative approach with the Technology Acceptance Model as a basic framework. Data was collected from 13 public service applications in different areas, gathered through 13 municipal information and communication’ officials, interviews with 38 conventional public service applicants, 282 digital services users, and the policies and regulations as secondary data, those analyzed by NVivo and visualized on a hierarchy chart. It is clear that while becoming digitized is an ambitious agenda, there are wide gaps among municipalities: geographical landscape, technology infrastructure, financial and human resources. On the public side, a majority remained stuck to conventional services, primarily due to non-technology factors: their comfort with traditional processes, the perceived complexity of the application, their digital literacy, experiences, and economic-societal barriers, all of which emerged as barriers to digital services acceptance. Injecting digital technology in the public sector is inevitable. However, it is necessary to build community digital readiness despite technology infrastructure and official capabilities, especially in peripheral local governments.
Accuracy of Machine Learning in Detecting Pediatric Epileptic Seizures: Systematic Review and Meta-Analysis (Preprint)
Authors: Zou Zhuan , Chen Bin , Xiao Dongqiong , Tang Fajuan , Li Xihong
Published: December 2024

BACKGROUND

Real-time monitoring of pediatric epileptic seizures poses a significant challenge in clinical practice. In recent years, machine learning (ML) has attracted substantial attention from researchers for diagnosing and treating neurological diseases, leading to its application for detecting pediatric epileptic seizures. However, systematic evidence substantiating its feasibility remains limited.

OBJECTIVE

This systematic review aimed to consolidate the existing evidence regarding the effectiveness of ML in monitoring pediatric epileptic seizures with an effort to provide an evidence-based foundation for the development and enhancement of intelligent tools in the future.

METHODS

We conducted a systematic search of the PubMed, Cochrane, Embase, and Web of Science databases for original studies focused on the detection of pediatric epileptic seizures using ML, with a cutoff date of August 27, 2023. The risk of bias in eligible studies was assessed using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies–2). Meta-analyses were performed to evaluate the C-index and the diagnostic 4-grid table, using a bivariate mixed-effects model for the latter. We also examined publication bias for the C-index by using funnel plots and the Egger test.

RESULTS

This systematic review included 28 original studies, with 15 studies on ML and 13 on deep learning (DL). All these models were based on electroencephalography data of children. The pooled C-index, sensitivity, specificity, and accuracy of ML in the training set were 0.76 (95% CI 0.69-0.82), 0.77 (95% CI 0.73-0.80), 0.74 (95% CI 0.70-0.77), and 0.75 (95% CI 0.72-0.77), respectively. In the validation set, the pooled C-index, sensitivity, specificity, and accuracy of ML were 0.73 (95% CI 0.67-0.79), 0.88 (95% CI 0.83-0.91), 0.83 (95% CI 0.71-0.90), and 0.78 (95% CI 0.73-0.82), respectively. Meanwhile, the pooled C-index of DL in the validation set was 0.91 (95% CI 0.88-0.94), with sensitivity, specificity, and accuracy being 0.89 (95% CI 0.85-0.91), 0.91 (95% CI 0.88-0.93), and 0.89 (95% CI 0.86-0.92), respectively.

CONCLUSIONS

Our systematic review demonstrates promising accuracy of artificial intelligence methods in epilepsy detection. DL appears to offer higher detection accuracy than ML. These findings support the development of DL-based early-warning tools in future research.

CLINICALTRIAL

PROSPERO CRD42023467260; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023467260
Selection of Soybean Genotypes in the Central Region of Tocantins
Authors: Almeida Lerisvan Pereira de , Sant’Anna Vânia Camila Almeida de
Published: December 2024

Brazilian agribusiness enables two consecutive harvests in the same year using early soybean cultivars. Understanding the interaction between environments and soybean genotypes is crucial for adapting cultivars and ensuring production stability. This study aimed to select early soybean genotypes in the central region of Tocantins. The experiment was conducted in Porto Nacional under rainfed and irrigated conditions, evaluating 40 soybean genotypes, including lines and commercial cultivars. A randomized block design with three replications was used, with plots consisting of four 5-meter rows spaced 0.50 meters apart. Grain productivity (sc. ha-1), cultivation cycle (days), and lodging index were analyzed. Data were subjected to variance analysis via SISVAR software, and means were compared using the Scott & Knott test at a 5% probability level. The coefficient of variation and accuracy estimates assessed experimental precision. Nineteen genotypes exceeded the national average for grain productivity. The cultivation cycle ranged from 91 to 109 days, with an 18-day variation. Under rainfed conditions, none of the genotypes showed susceptibility to lodging, but in the irrigated condition, 9 genotypes exhibited high lodging scores. Four genotypes—20285INT1835, 20204INT108701, 18610INT21205, and 20652INT102372—stood out for combining high productivity, absence of lodging, and an early cycle of 99-101 days. These genotypes demonstrate significant potential for agricultural systems in the Tocantins region.
МЫ ВОССТАНАВЛИВАЕМ СИСТЕМУ ПОДГОТОВКИ УНИКАЛЬНЫХ СПЕЦИАЛИСТОВ, В КОТОРЫХ ОСТРО НУЖДАЕТСЯ ЭЛЕКТРОННАЯ ОТРАСЛЬ
Authors: Дронов А.А.
Published: December 2024

В апреле 2022 года стартовал
федеральный проект Минобрнауки России
«Передовые инженерные школы» (ПИШ),
в качестве цели которого обозначено
обеспечение высокопроизводительных
экспортно ориентированных секторов
экономики страны высококвалифицирован-
ными кадрами для достижения технологической
независимости, а также создание новейших
видов высокотехнологичной продукции
в партнерстве с высокотехнологичными
компаниями Российской Федерации. В конце
прошлого года в рамках второго отбора грант на
создание ПИШ получил один из ключевых вузов
нашей отрасли, известный как «кузница кадров
электронной промышленности» – Национальный
исследовательский университет «Московский
институт электронной техники» (НИУ МИЭТ).
Об особенностях проекта «Передовые
инженерные школы», направлениях, в которых
он развивается в университете, и первых
достигнутых результатах его реализации нам
рассказал заместитель директора ПИШ МИЭТ,
заместитель директора по научной работе
Института перспективных материалов
и технологий НИУ МИЭТ, к. т. н., доцент
Алексей Алексеевич Дронов.
Saint Nerses Shnorhali as a Unique Figure in Overall Christian Thought and Praxis: Shnorhali’s Pioneering Vision of Christian Unity
Authors: Zekiyan Boghos Levon
Published: December 2024

This study aims to clarify the main reasons, why Saint Nerses Shnorhali is a unique figure in the overall Christian tradition. His extraordinary achievements in the most different fields of intellectual creativity and human behaviour as a monk and a Church leader, as a highly talented poet and musician, as an original, profound interpreter and commentator of the Holy Scriptures, a great promoter of reforms or, rather, innovations in the liturgical celebration; and a charismatic mentor capable of making high culture both in its religious and profane dimensions accessible to the simplest classes of population, are certainly serious arguments to rank Shnorhali as a first-class religious leader and an exceptional figure in the overall Christian tradition.
Performance analysis of priority generation system for multimedia video using anfis classifier
Authors: S.P. Lalitha  , A. Murugan
Published: December 2024

The priority-based multimedia video transmission over the cloud system uses different bandwidth functioned multimedia video information which has been sent or transmitted to the cloud system through the priority selection system. This priority selection system uses machine learning algorithm for selecting the highest priority of the multimedia video and passes the multimedia video having the high priority to the cloud system. The proposed Workflow Computations and Scheduling (WCS) system using machine learning algorithm has consisted of three stages as preprocessing, feature computations with Principal Component Analysis (PCA) and Adaptive Neuro Fuzzy Inference System (ANFIS) classifier. The preprocessing stage of the proposed system is used to separate the frames from each multimedia video and the RGB frame has been converted into grey scale frame in this stage. The features are estimated from each grey scale frame and these features are scrutinized using PCA. The final scrutinized features are fed into ANFIS classifier to generate the priority results. The performance of the proposed WCS system has been analyzed in Amazon EC2 cloud environment with respect to Make Span (MS) and Execution Cost (EC).
Optimizing Wireless Sensor Networks: A Deep Reinforcement Learning-Assisted Butterfly Optimization Algorithm in MOD-LEACH Routing for Enhanced Energy Efficiency
Authors: M. Devika  , S. Maflin  Shaby
Published: December 2024

Wireless Sensor Networks (WSNs) play a crucial role in diverse applications, necessitating the development of energy-efficient routing protocols to extend network lifetime. This study proposes a novel Deep Reinforcement Learning-Assisted Butterfly Optimization Algorithm (DRL-BOA) integrated with the MOD-LEACH protocol to optimize routing in WSNs. The proposed hybrid approach leverages the exploration and exploitation capabilities of BOA and the adaptive decision-making power of DRL to dynamically select cluster heads and optimal routes based on network conditions. The DRL-BOA model was evaluated on various WSN scenarios with node densities ranging from 50 to 500, considering parameters such as energy consumption, packet delivery ratio (PDR), throughput, and network lifetime. Simulation results demonstrated that the proposed method achieved a 22% reduction in energy consumption compared to traditional MOD-LEACH, a 15% improvement in PDR, a 27% increase in throughput, and an 18% enhancement in network lifetime over the Hybrid PSO-GWO approach. These significant improvements highlight the effectiveness of the DRL-BOA model in overcoming the limitations of existing algorithms. The proposed framework demonstrates superior adaptability to dynamic network conditions, making it a promising solution for energy-efficient and reliable WSN operations. Future work will explore integrating this model with emerging technologies, such as edge computing and the Internet of Things (IoT), for further enhancements
Innovations in Medical Education in Gastrointestinal Surgery Using Interactive Anatomical Tables
Authors: Kashtanov A. D. , Stetsyk E. O. , Dydykin S. S. , Kytko O. V. , Trunin E. M. , Aleshkina O. Yu. , Lavrentieva A. N. , Andreeva A. N. , Alekseeva D. S. , Muratova A. A. , Kharina A. Yu. , Tatarkin V. V. , Sokolova A. S. , Filatov V. N. , Samodova I. L. , Makeeva E. A. , Pekeldina E. S. , Kapitonova M. Yu. , Bikbaeva T. S. , Polkovova I. A. , Volel B. A. , Litvinova T. M. , Dudnik E. N. , Kireeva N. V. , Ivashkin K. V. , Vasil’ev Yu. L.
Published: December 2024

The introduction of digital technologies into the learning process for medical university students represents a new paradigm in medical education since high level of criteria for assessing the quality of learning of a medical student require the application of modern technologies in training fundamental disciplines and, in particular, anatomy. Thanks to virtual technologies, conditions are created for modeling and integrating the student into conditions close to real ones, which increases the interest and involvement of students in the educational process and, as a result, a subjective improvement in the process of assimilation of the material. Traditional education based on dissection materials cannot fully provide for the massive training of students, as biological materials cannot be restored or preserved and are quickly damaged. 3D models are devoid of these limitations.

Aim: to evaluate the effectiveness of digital dissection in the educational trajectory of clinical anatomy using interactive anatomical tables and the need of students for the active use of these aids.

Materials and methods. Four groups of students were formed: three groups were studying the material using various anatomical tables and one group used the traditional method. To control the effectiveness of the educational process, before the start of training, entrance testing was conducted in all groups. At the end of classes on individual topics, participants completed exit testing, as well as a questionnaire.

Results. The analysis of learning outcomes shows a significantly higher level of absorption of the material among students in groups where 3D anatomical models were used during classes. This indicates that students’ subjective experience of the learning process has improved due to their increased involvement in the class and their interest in innovative teaching methods.

Conclusion. We plan to study learning outcomes in more detail to identify any differences in the formation of general and professional competencies among students. This information will help us make informed decisions about the widespread use of anatomical models in educational practice.
Challenges in Diagnosing Intrahepatic Cholangiolithiasis in a 39-Year-Old Patient
Authors: Guseva A. K. , Sergeyeva O. N. , Nekrasova T. P. , Imaraliev O. T. , Okhlobystin A. V. , Shirokova Y. N. , Ostrovskaya A. S. , Zharkova M. S. , Cherenda A. S. , Ivashkin V. T.
Published: December 2024

Aim: to highlight the challenges of diagnosing and treating a patient with severe intrahepatic cholangiolithiasis.

Key points. Primary sclerosing cholangitis is a chronic progressive liver disease characterized by destructive inflammation and fibrosis in the bile ducts, leading to biliary strictures, secondary biliary cirrhosis, portal hypertension and liver failure. Cholangiolithiasis occurs in more than half of cases of primary sclerosing cholangitis and can be both a complication and a cause of secondary sclerosing cholangitis, maintaining inflammation in the ducts and facilitating stone formation. Genetic mutations are known to contribute to the development of gallstones in young patients, including low phospholipid-associated cholelithiasis. Despite the wide range of modern methods of radiological and endoscopic diagnostics, there are still difficulties in differential diagnostics of bile duct diseases. This article presents a clinical case of a 39-year-old male patient with primary sclerosing cholangitis, dyslipidemia and multiple cholangioliths in the gallbladder, intraand extrahepatic bile ducts.

Conclusion. The presented clinical case demonstrates the difficulties in assessing pathogenesis, choosing diagnostic and therapeutic approaches in patients with severe intrahepatic lithiasis that may mimic hepatic neoplasm. Combination of non-invasive and endoscopic methods, such as magnetic resonance imaging, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography, and cholangioscopy, appears to be the most effective both diagnostically and therapeutically.
Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research)
Authors: Ivashkin V. T. , Trukhmanov A. S. , Maev I. V. , Drapkina O. M. , Livzan M. A. , Martynov A. I. , Lapina T. L. , Paraskevova A. V. , Andreev D. N. , Alexeeva O. P. , Alekseenko S. A. , Baranovsky A. Yu. , Zayratyants O. V. , Zolnikova O. Yu. , Dronova O. B. , Kliaritskaia I. L. , Korochanskaya N. V. , Kucheryavyy Yu. A. , Mammaev S. N. , Osipenko M. F. , Pirogov S. S. , Poluektova E. A. , Rumyantseva D. E. , Sayfutdinov R. G. , Storonova O. A. , Uspenskiy Yu. P. , Khlynov I. B. , Tsukanov V. V. , Sheptulin A. A.
Published: December 2024

Aim. These recommendations are developed for practitioners in order to familiarize them with modern diagnostic methods, management features and pharmacotherapy of patients with gastroesophageal reflux disease (GERD).

General provisions. GERD is the most common reason for patients to visit clinics. There are esophageal and extraesophageal manifestations of GERD. Patients' complaints of heartburn and regurgitation remain the most sensitive and specific clinical manifestations of GERD. The diagnosis of GERD is established on the basis of anamnestic data, instrumental examination (detection of reflux esophagitis during upper gastrointestinal endoscopy, detection of pathological gastroesophageal reflux with 24-hour pH-metry or/and 24-hour pH-impedance monitoring). Patients with suspected GERD and the absence of erosive and ulcerative changes in the mucous membrane of the esophagus or the presence of erosive esophagitis of Grade A according to Los Angeles Classification of Gastroesophageal Reflux Disease are recommended to conduct 24-hour pH-metry on PPI off to exclude or confirm the diagnosis of GERD. Patients with extraesophageal manifestations of GERD without classic symptoms (heartburn, regurgitation) are recommended to undergo 24-hour pH-impedance monitoring with discontinuation of proton pump inhibitor therapy. When deciding on surgical treatment, all patients need to perform high-resolution esophageal manometry and 24-hour pH-impedance monitoring. Complications of GERD include bleeding, strictures, Barrett’s esophagus and esophageal adenocarcinoma. The main groups of medications used in the treatment of GERD are proton pump inhibitors (PPIs), potassium-competitive acid blockers (P-CABs), alginates, antacids, and prokinetics. PPIs are the drugs of choice in the treatment of both symptoms of gastroesophageal reflux disease and existing erosive esophagitis. Combination therapy Rebamipide with PPIs increases the effectiveness of relief of GERD symptoms, as well as reduces the frequency of relapses.

Conclusion. These clinical recommendations will improve the quality of medical care for patients with GERD.
Genetics of Inflammatory Bowel Disease: Current Understanding and Future Directions
Authors: Chandra Sekar P. K. , Veerabathiran R.
Published: December 2024

Aim: to present literature data on the genetic underpinnings of inflammatory bowel disease (IBD), focusing on key genetic variants such as NOD2, ATG16L1, and IL23R; The objective of this was to understand how these genetic factors contribute to immune dysregulation, epithelial barrier dysfunction, and mucosal homeostasis in IBD.

Key points. IBD, encompassing Crohn's disease and ulcerative colitis, is intricately shaped by a nexus of genetic and environmental factors, and its global prevalence is increasing. Genetic research has identified pivotal variants — NOD2, ATG16L1, and IL23R — linked to IBD, influencing key pathways, such as autophagy, interleukin signaling, and bacterial management. These genetic variants, integral to IBD's etiology of IBD, have functional significance because they perturb immune regulation, compromise epithelial barrier integrity, and disrupt mucosal homeostasis, collectively contributing to intestinal inflammation through diverse mechanisms. Early detection of IBD is paramount for arresting disease progression and underscoring the importance of prognostic testing and genetic screening, especially in cases with familial predispositions or very early onset IBD. Additionally, the use of certain IBD medications, such as corticosteroids, azathioprine, and infliximab, may have implications for male fertility, necessitating a nuanced understanding of these potential effects for informed decision-making in IBD management. This comprehensive understanding of the genetic landscape, functional implications, and diagnostic strategies is vital for advancing personalized treatments and improving outcomes in individuals with IBD.

Conclusion. IBD is a complex gastrointestinal disorder influenced by a combination of genetic and environmental factors. Genetic variants, including NOD2, ATG16L1, and IL23R, contribute to dysregulation of immune responses, epithelial barrier function, and mucosal homeostasis. While progress has been made in understanding the genetic landscape of IBD, ongoing research is needed to elucidate the functional consequences of these variants, identify causal genes, and explore gene-environment interactions. This deeper understanding holds the potential for more precise diagnostics and personalized treatments, ultimately improving outcomes in individuals living with IBD.
Hyperparathyroidism in Patients with End-Stage Chronic Liver Disease (Clinical Observations)
Authors: Lavreniuk A. A. , Gorbacheva A. N. , Bibik E. E. , Eremkina A. K. , Tikhonov I. N. , Mokrysheva N. G.
Published: December 2024

Aim: to present disorders of mineral and bone metabolism in patients with chronic liver diseases through clinical observations.

Key points. The liver plays an important role in mineral metabolism: metabolic activation of vitamin D, synthesis of vitamin D-binding protein and albumin, metabolism of parathyroid hormone, etc. However, data on the development of mineral metabolism disorders, particularly hyperparathyroidism, in this population are very limited. Bone diseases such as osteoporosis and osteomalacia are quite common in chronic liver disease, especially in cirrhosis and cholestatic diseases; however, the pathogenesis of these disorders and their relationship with mineral metabolism remain poorly understood. The article presents cases of severe primary hyperparathyroidism (PHPT) in patients with chronic liver disease. In one patient with a long history of viral hepatitis C and cirrhosis, PHPT manifested with severe bone complications, including multiple vertebral compression fractures and a subsequent femoral neck fracture. Imaging studies revealed lesions of all four parathyroid glands, and the removal of the largest lesion did not result in disease remission. In the second case described, PHPT was diagnosed in a patient with bone pain and osteoporosis following orthotopic liver transplantation for Budd — Chiari syndrome with cirrhosis. One year after the initial surgical treatment for PHPT, the patient experienced a recurrence of the disease, with confirmed multiglandular lesion.

Conclusion. In patients with chronic liver diseases, disorders of mineral and bone metabolism remain a significant yet not fully understood problem. Further studies are needed to develop therapeutic approaches for this group of patients to prevent the onset of late, disabling complications.
Dynamic interactions of research, publication, researchers, institutions, and countries: A Quintuple Helix model perspective on research impact
Authors: (Corresponding Author) Mudassar Arsalan , Mubin Omar , Al Mahmud Abdullah
Published: December 2024

This review paper introduces and explores the Research Impact Quintuple Helix Model, a comprehensive framework designed to analyse and enhance the impact of research across societal, economic, and environmental dimensions. Unlike traditional models focusing on sectoral collaboration for innovation and economic development, this model integrates five critical elements - Research, Publication, Researchers, Institutions, and Countries - offering a holistic approach to understanding research impact. The study systematically examines the dynamic interactions among these elements, emphasising their collective role in fostering collaborative synergies, interdisciplinary research, and effective resource allocation. By aligning research activities with broader societal needs and environmental considerations, the model aims to extend the scope of research impact beyond academic achievements, highlighting the importance of policy alignment, societal engagement, and sustainable practices. Key comparisons with the standard Helix models demonstrate the unique contributions of the research impact quintuple helix model, illustrating its potential to address specific challenges in maximising research benefits. The paper identifies strategic collaborations and policy implications that could significantly enhance the societal benefits of research, advocating for a structured integration of the model’s elements into research and policy-making processes. The review concludes by recognising limitations in the existing literature and calling for empirical studies to validate and refine the model. Future research should incorporate quantitative methods to measure the impact effectively, aiming to transform theoretical insights into actionable strategies for a sustainable and impactful research ecosystem.
The Emerging Data Center Market in Armenia and Opportunities for Sustainable Growth
Authors:   Consultant, Gidwani Mohit , Avetisyan Narine ,   Asian Development Bank, Jeong Yoonee ,   Asian Development Bank, Apikul Christine ,   Consultant of Asian Development Bank
Published: December 2024

This brief analyzes Armenia’s emerging data center market and shows why it needs to expand its green energy, adopt carbon-efficient technology, and accommodate the latest technology trends to maximize its growth potential.

The brief highlights forecasts for Armenia to increase its data center racks from 550 to up to 2,000 by 2028 and explains how its location alongside government support and financing gives it a competitive advantage. It recommends Armenia look to enhance its resilient international connectivity, accommodate generative artificial intelligence and edge computing requirements, and promote greener data centers to help make the energy-intensive sector’s growth more sustainable.
Intensive Glucose Lowering and Its Effects on Vascular Events and Death According to Age at Diagnosis and Duration of Diabetes: The ADVANCE Trial
Authors: Ohkuma Toshiaki , Harris Katie , Woodward Mark , Hamet Pavel , Harrap Stephen , Mancia Giuseppe , Marre Michel , Poulter Neil , Chalmers John , Zoungas Sophia ,   ADVANCE Collaborative Group
Published: December 2024

OBJECTIVE

To compare the vascular effects of pursuing more versus less glucose lowering in patients with younger or older age at diabetes diagnosis, and with shorter or longer diabetes duration.

RESEARCH DESIGN AND METHODS

We studied 11,138 participants from the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial, classified into subgroups defined by age at diabetes diagnosis (≤50, >50–60, and >60 years) and diabetes duration (≤5, >5–10, and >10 years).

RESULTS

Intensive glucose lowering significantly lowered the risk of the primary composite outcome of major macrovascular and microvascular events (hazard ratio 0.90, 95% CI 0.82–0.98) with no evidence of heterogeneity in the proportional effects across subgroups defined by age at diagnosis or diabetes duration (P for heterogeneity = 0.86 and 0.47, respectively). Similar consistent treatment effects were also observed for all-cause death, cardiovascular death, and the components of major vascular events.

CONCLUSIONS

Intensive glucose lowering may be recommended irrespective of age at diagnosis or diabetes duration.
Evaluación del impacto de la integración multisensorial en el desarrollo neurosensorial de niños preescolares: un estudio en el Centro de Desarrollo Neurosensorial y Rehabilitación Integral Úpala Kids
Authors:   Instituto Superior Tecnológico Martha Bucaram De Roldós Ecuador, Dahua Robelly Jaime Efraín , Baño Mena Marcia Liliana ,   Instituto Superior Tecnológico Martha Bucaram De Roldós Ecuador, Hurtado Abad Jheny del Rocío ,   Instituto Superior Tecnológico Martha Bucaram De Roldós Ecuador, Barrionuevo Silva Lilian Jazmina ,   Instituto Superior Tecnológico Martha Bucaram De Roldós Ecuador
Published: December 2024

El presente estudio tuvo como propósito examinar el impacto de la integración multisensorial en el desarrollo neurosensorial de niños en edad preescolar, atendidos en el Centro de Desarrollo Neurosensorial y Rehabilitación Integral Úpala Kids. El objetivo central consistió en determinar cómo la exposición a experiencias sensorialmente enriquecidas contribuía a mejorar las habilidades cognitivas, motoras, lingüísticas y socioemocionales.

La investigación involucró a un total de 23 niños, observados a lo largo de un año académico. Durante este periodo, se aplicaron estrategias sistemáticas de estimulación multisensorial y se evaluaron cambios en dimensiones clave del desarrollo, incluyendo memoria, atención, procesamiento sensorial, destrezas motrices y competencias socioemocionales.

El enfoque metodológico fue cuantitativo y correlacional, empleando instrumentos estandarizados como la Alberta Infant Motor Scale (AIMS) y una versión adaptada de la Escala de Desarrollo de Bayley. Además, se complementaron las mediciones con observaciones directas y entrevistas a educadores y padres, lo cual permitió obtener información más completa y contextualizada.

Los resultados mostraron mejoras significativas en todas las áreas examinadas. La coordinación motora fina y gruesa aumentó en un 30%, mientras que las capacidades cognitivas, particularmente en memoria y atención, mejoraron en un 35%. Asimismo, las habilidades socioemocionales, como interacción y empatía, crecieron en un 40%. Por otra parte, el desempeño lingüístico, medido a través de la comprensión y el vocabulario, experimentó un incremento del 28%.

En conclusión, la integración multisensorial se evidenció como un enfoque efectivo para fortalecer múltiples dimensiones del desarrollo infantil. Estos hallazgos respaldan la relevancia de entornos sensorialmente ricos en el diseño de intervenciones educativas y terapéuticas durante la primera infancia.
The Role of Micronutrients in Skin Health
Authors: R Danil , Dalimunthe Dina A
Published: December 2024

Micronutrients play a crucial role in maintaining the skin health, one of the most complex and largest organs in the human
body. Skin health can be influenced by proper nutritional intake including vitamins and minerals. Despite their requirement
in small quantities, micronutrients are fundamental to maintain structural integrity and function of the skin. Micronutrient
deficiencies are precursor to various dermatological conditions such as xerosis and other skin diseases. Dermatologists are
key in identifying and handling these nutrition-related problems. As awareness towards the importance of nutrition for
skin health grows, understanding the role of micronutrients has become increasingly relevant in modern dermatology. This
review aims to thoroughly examine the roles and implications of micronutrients in dermatological conditions arising from
deficiencies.
HSIL in a 32-Year-Old Patient with 11 Years of Normal Cytology and a Positive High-Risk HPV Test: A Case Report
Authors: Finger Natasha , Victoros-Khristianov Alkistis , Pavlides Giannis , Bazoukis Xenofontas
Published: December 2024

In Cyprus: Among women aged 15-45 years of age - cervical cancer is the 3rd most common female cancer and is also the 3rd leading cause of female cancer deaths. The most commonly identified and well-known causative factor is HPV virus. Our case refers to a 32-year-old woman that had consecutive normal pap smear cytology results, for 11 years. At her last visit, a cervical sample was taken for HPV identification (a pilot program). The results revealed an infection with high-risk HPV strains. During the colposcopy that followed, HSIL was diagnosed and a loop excision was crucial to treat the precancerous lesion. This case highlights the primary causative factor of cervical cancer and underscores the importance of HPV DNA testing in the early identification of premalignant lesions.
Implementation of Teacher’s Duties in the Implementation of the Independent Curriculum at the State Vocational School of Padang City`
Authors: Wanda Lestari  , Sulastri
Published: December 2024

This research is motivated by the problem that the implementation of teacher’s duties is still not optimal in the implementation of the independent curriculum at the State Vocational School in Padang city. This study aims to obtain information and describe the implementation of teacher’s duties in the implementation of the independent curriculum which is seen from several aspects including learning planning, learning implementation, assessment, processing of assessment results, reporting of learning outcomes, as well as reflection and follow-up of learning and assessment. This type of research is quantitative descriptive research. The population of this study is all teachers of Padang City State Vocational School with civil servant status totaling 635 teachers. The sample taken in this study was 112 civil servant teachers who were determined by the proportional stratified Random Sampling technique. The instrument in this study uses a Likert scale model questionnaire with five answer options that have been tested for validity and reliability. The data was processed using the mean formula. The results of this study stated that the Implementation of Teacher Duties in the Implementation of the Independent Curriculum at the State Vocational School of Padang City with an average score of 4.44 was in the good category. This shows that the implementation of teacher’s duties in the implementation of the independent curriculum at the State Vocational School in Padang City is good.
Projected Needs of State Junior High School Teachers in Linggo Sari Baganti District in 2025-2029
Authors: Sasmita Yulia , Irsyad
Published: December 2024

This study aims to describe the needs of teachers, especially in the State Junior High School of Linggo Sari Baganti District in 2025-2029 so that teacher problems can be resolved. This research is a descriptive research with a qualitative method. The subject of this research is a subject teacher in accordance with the applicable curriculum, namely the Independent Curriculum. The data collection method is secondary data documentation. The data analysis technique used is the ectrapolution projection technique. The results of the study show that the students of State Junior High School in Linggo Sari Baganti District are gradually decreasing every year. However, this decrease in students did not make a significant reduction in the number of study groups because the number of students in one group was still in the normal category. From the projection of teacher needs, it can be seen that State Junior High Schools in Linggo Sari Baganti District in 2025-2029 in PAI subjects need 1 ASN teacher; Pancasila Education 1 ASN teacher; Indonesian 8 ASN teachers;. Mathematics 5 ASN teachers; Science 5 ASN teachers; IPS 4 ASN teachers; English 3 ASN teachers; PJOK 3 ASN teachers; Informatics 4 ASN teachers; Arts and Crafts 7 ASN teachers.
Stability-Indicating and RP-HPLC Method for Analyzing Amlodipine Besylate in Commercially Available Drug Products in Kurdistan, Iraq
Authors: Qasim Faroq O. , Sher Mohammed Nidhal M. , Yousif Nzar I. , Fattah Muhammed H.
Published: December 2024

This study aims to develop and validate a stability-indicating HPLC method for the simultaneous determination of Amlodipine (Amlo) in bulk and tablet dosage forms. The method’s goal is to evaluate the stability and degradation of Amlo under various stress conditions. The method was optimized using high-performance liquid chromatography (HPLC) with a UV detector. The mobile phase consisted of water and methanol in a 50:50 (v/v) ratio. An Eclipse XDB-C18 column (4.6 mm × 250 mm, 5 μm) was used for separation. The analysis was carried out at room temperature (25°C) with a 10 μL injection volume, a flow rate of 1.2 mL/min, and detection at 360 nm. Method validation was conducted in terms of linearity, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). The stability of Amlodipine in tablet forms, under various stress conditions (acidic, alkaline, oxidative, thermal, and photolytic), was also evaluated. The finding showed excellent linearity (R² = 0.994) in the concentration range of 5–25 μg/mL. Precision was demonstrated by a relative standard deviation (RSD) of less than 0.8%. The LOD and LOQ were found to be 0.65 μg/mL and 2.16 μg/mL, respectively. Accuracy was assessed at three different levels, yielding recoveries above 98%. The method successfully detected the degradation products of Amlo under the applied stress conditions. The developed and validated HPLC method is simple, precise, and accurate for the simultaneous determination of Amlodipine in bulk and tablet forms. It is reliable for evaluating the stability and degradation of Amlo under different stress conditions, making it suitable for routine quality control and stability testing of Amlo-based pharmaceutical products.
Хвилі кручення в шаруватих композитних нестисливих матеріалах з початковими
напруженнями при проковзуванні шарів
Authors: Глухов A. Ю. , Бабич С. Ю. , Млавець Ю. Ю. , Рейтій О. К.
Published: December 2024

В рамках лінеаризованої теорії пружності для тіл з початковими напруженнями
розглянуті постановка та метод розв'язку задач про поширення хвиль кручення в шаруватих
композитних нестисливих заздалегідь напружених матеріалах при проковзуванні шарів.
Досліджено випадок поширення хвиль вздовж шарів. Отримані дисперсійні рівняння для
симетричних і антисиметричних хвиль та їх довгохвильові наближення.
Усереднення в задачі диференціальної гри переслідування за наявності
багаточастотних збурень
Authors: Бардан А. О.
Published: December 2024

У роботі розглядається задача диференціальної гри переслідування, коли на рух
переслідувача і втікача накладені зовнішні малі збурення. Застосовано та обґрунтовано
метод усереднення за швидкими змінними для побудови спрощеної системи рівнянь.
Досліджено вплив багаточастотних збурень на конфліктно-керований процес. Доведено
існування та єдиність розв'язку початкової задачі і побудовано оцінку відхилення
розв'язків точної усередненої системи з однаковими початковими умовами на довільному
скінченному часовому відрізку [0, L]. Розглянуто випадки, коли матриця лінійної частини
залежить як від часу, так і від амплітудних змінних. Наведено приклад диференціальної
гри «Простий рух», який модифіковано через накладення збурень, та знайдено час
завершення переслідування для точної задачі та у випадку зі збуренням. Проаналізовано
вплив збурень на існування розв'язку та на час завершення переслідування диференціальної
гри.
Розвиток штучного інтелекту і його застосування в бібліотечній справі
Authors: Ічанська Н. В. , Лисенко М. В. , Пікалова В. В.
Published: December 2024

Стаття розглядає роль штучного інтелекту (ШІ) в сучасній бібліотечній справі. У
роботі досліджено можливості застосування ШІ для покращення обслуговування користувачів,
оптимізації робочих процесів та розвитку цифрових бібліотечних сервісів. Автори
досліджують різні аспекти, включаючи покращений пошук інформації, який дозволяє
користувачам швидко та ефективно знаходити релевантну літературу. У статті звертається
увага на персоналізовані рекомендації, які надають користувачам індивідуально
налаштовані рекомендації щодо літератури та джерел інформації. Автоматизація процесів
каталогізації та управління колекціями спрощує роботу бібліотекарів та дозволяє
бібліотекам ефективно управляти своїми ресурсами. Взаємодія з користувачами через
чат-ботів та віртуальних асистентів стає більш інтерактивною та зручною. Розвиток
цифрових архівів та електронних ресурсів робить доступ до інформації більш швидким та
зручним для користувачів. Для управління мережею бібліотек на рівні країни або регіонів
ефективним є застосування нейромережевих технологій.
У роботі автори використали ці технології для прогнозування кількості відвідувань
бібліотек та звернень до їхніх web-сайтів (на прикладі Полтавської області). Результати
дослідження можуть бути використані фахівцями у сфері бібліотечної справи з метою
покращення обслуговування читачів і подальшого вдосконалення сучасних бібліотечних
сервісів.
Нечітка модель оцінки безпеки міжнародних та транскордонних процесів
співробітництва з урахуванням ризикових факторів
Authors: Поліщук В. В. , Поліщук І. В. , Матей А. А. , Феделеш Ю. Ю.
Published: December 2024

Проведено дослідження актуальної задачі розроблення нечіткої моделі оцінки безпеки
міжнародних та транскордонних процесів співробітництва, з урахуванням ризикових факторів
та експертних висновків щодо можливості досягнення мети стосовно гарантування
національних безпек країн-партнерів.
В основу дослідження покладений апарат нечітких множин, що базується на інтервалах
оцінок. Кожен ризик-орієнтований фактор впливу на виконання міжнародних та
транскордонних процесів співробітництва оцінюється лінгвістичним висновком експерта щодо
рівня ймовірності настання ризикової ситуації, описану відповідним критерієм та числа
впевненості міркувань експерта для такого висновку. Новаторською особливістю моделі є
врахування експертного висновку щодо можливості досягнення мети стосовно гарантування
національних безпек країн-партнерів при міжнародному або транскордонному
співробітництві. Модель розкриває нечіткість вхідних оцінок, здатна вивести лінгвістичне
значення рівня безпеки міжнародних та транскордонних процесів співробітництва та його
оцінку достовірності, чим підвищує ступінь обґрунтованості прийняття подальших
управлінських рішень.
Подальше дослідження проблематики вбачаємо в розроблені математичних моделей та
програмної підтримки для оцінювання проектів транскордонного співробітництва за умов
гарантування національних безпек країн-партнерів при реалізації проекту.