bluuebunny/crossref_metadata_2025 huggingface dataset:
Accurate Computation of Airfoil Flow Based on the Lattice Boltzmann Method
Authors: Wang Liangjun , Zhang Xiaoxiao , Zhu Wenhao , Xu Kangle , Wu Weiguo , Chu Xuesen , Zhang Wu
Published: May 2019

The lattice Boltzmann method (LBM) is an important numerical algorithm for computational fluid dynamics. This study designs a two-layer parallel model for the Sunway TaihuLight supercomputer SW26010 many-core processor, which implements LBM algorithms and performs optimization. Numerical experiments with different problem sizes proved that the proposed model has better parallel performance and scalability than before. In this study, we performed numerical simulations of the flows around the two-dimensional (2D) NACA0012 airfoil, and the results of a series of flows around the different angles of attack were obtained. The results of the pressure coefficient and lift coefficient were in good agreement with those in the literature.
Visual Saliency Detection Using a Rule-Based Aggregation Approach
Authors: Lopez-Alanis Alberto , Lizarraga-Morales Rocio A. , Sanchez-Yanez Raul E. , Martinez-Rodriguez Diana E. , Contreras-Cruz Marco A.
Published: May 2019

In this paper, we propose an approach for salient pixel detection using a rule-based system. In our proposal, rules are automatically learned by combining four saliency models. The learned rules are utilized for the detection of pixels of the salient object in a visual scene. The proposed methodology consists of two main stages. Firstly, in the training stage, the knowledge extracted from outputs of four state-of-the-art saliency models is used to induce an ensemble of rough-set-based rules. Secondly, the induced rules are utilized by our system to determine, in a binary manner, the pixels corresponding to the salient object within a scene. Being independent of any threshold value, such a method eliminates any midway uncertainty and exempts us from performing a post-processing step as is required in most approaches to saliency detection. The experimental results on three datasets show that our method obtains stable and better results than state-of-the-art models. Moreover, it can be used as a pre-processing stage in computer vision-based applications in diverse areas such as robotics, image segmentation, marketing, and image compression.
Change Detection and Impact of Climate Changes to Iraqi Southern Marshes Using Landsat 2 MSS, Landsat 8 OLI and Sentinel 2 MSI Data and GIS Applications
Authors: Hashim Bassim Mohammed , Sultan Maitham Abdullah , Attyia Mazin Najem , Al Maliki Ali A. , Al-Ansari Nadhir
Published: May 2019

Marshes represent a unique ecosystem covering a large area of southern Iraq. In a major environmental disaster, the marshes of Iraq were drained, especially during the 1990s. Since then, droughts and the decrease in water imports from the Tigris and Euphrates rivers from Turkey and Iran have prevented them from regaining their former extent. The aim of this research is to extract the values of the normalized difference vegetation index (NDVI) for the period 1977–2017 from Landsat 2 MSS (multispectral scanner), Landsat 8 OLI (operational land imager) and Sentinel 2 MSI (multi-spectral imaging mission) satellite images and use supervised classification to quantify land and water cover change. The results from the two satellites (Landsat 2 and Landsat 8) are compared with Sentinel 2 to determine the best tool for detecting changes in land and water cover. We also assess the potential impacts of climate change through the study of the annual average maximum temperature and precipitation in different areas in the marshes for the period 1981–2016. The NDVI analysis and image classification showed the degradation of vegetation and water bodies in the marshes, as vast areas of natural vegetation and agricultural lands disappeared and were replaced with barren areas. The marshes were influenced by climatic change, including rising temperature and the diminishing amount of precipitation during 1981–2016.
A New Calibration Process for a Homogeneous Cyclorama Illumination in Virtual TV Sets
Authors: Méndez Roi , Castelló Enrique , Ríos Viqueira José Ramón , Flores Julián
Published: May 2019

A virtual TV set combines actors and objects with computer-generated virtual environments in real time. Nowadays, this technology is widely used in television broadcasts and cinema productions. A virtual TV set consists of three main elements: the stage, the computer-system and the chroma-keyer. The stage is composed by a monochrome cyclorama (the background) in front of which actors and objects are located (the foreground). The computer-system generates the virtual elements that will form the virtual environment. The chroma-keyer combines the elements in the foreground with the computer-generated environments by erasing the monochrome background and insetting the synthetic elements using the chroma-keying technique. In order to ease the background removal, the cyclorama illumination must be diffuse and homogeneous, avoiding the hue differences that are introduced by shadows, shines and over-lighted areas. The analysis of this illumination is usually performed manually by an expert using a photometer which makes the process slow, tedious and dependent on the experience of the operator. In this paper, a new calibration process to check and improve the homogeneity of a cyclorama’s illumination by non-experts using a custom software which provides both visual information and statistical data, is presented. This calibration process segments a cyclorama image in regions with similar luminance and calculates the centroid of each of them. The statistical study of the variation in the size of the regions and the position of the centroids are the key tools used to determine the homogeneity of the cyclorama lighting.
A Systematic Literature Review on Image Captioning
Authors: Staniūtė Raimonda , Šešok Dmitrij
Published: May 2019

Natural language problems have already been investigated for around five years. Recent progress in artificial intelligence (AI) has greatly improved the performance of models. However, the results are still not sufficiently satisfying. Machines cannot imitate human brains and the way they communicate, so it remains an ongoing task. Due to the increasing amount of information on this topic, it is very difficult to keep on track with the newest researches and results achieved in the image captioning field. In this study a comprehensive Systematic Literature Review (SLR) provides a brief overview of improvements in image captioning over the last four years. The main focus of the paper is to explain the most common techniques and the biggest challenges in image captioning and to summarize the results from the newest papers. Inconsistent comparison of results achieved in image captioning was noticed during this study and hence the awareness of incomplete data collection is raised in this paper. Therefore, it is very important to compare results of a newly created model produced with the newest information and not only with the state of the art methods. This SLR is a source of such information for researchers in order for them to be precisely correct on result comparison before publishing new achievements in the image caption generation field.
Pheochromocytomas and Paragangliomas: Bypassing Cellular Respiration
Authors: Cascón Alberto , Remacha Laura , Calsina Bruna , Robledo Mercedes
Published: May 2019

Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors that show the highest heritability of all human neoplasms and represent a paradoxical example of genetic heterogeneity. Amongst the elevated number of genes involved in the hereditary predisposition to the disease (at least nineteen) there are eleven tricarboxylic acid (TCA) cycle-related genes, some of which are also involved in the development of congenital recessive neurological disorders and other cancers such as cutaneous and uterine leiomyomas, gastrointestinal tumors and renal cancer. Somatic or germline mutation of genes encoding enzymes catalyzing pivotal steps of the TCA cycle not only disrupts cellular respiration, but also causes severe alterations in mitochondrial metabolite pools. These latter alterations lead to aberrant accumulation of “oncometabolites” that, in the end, may lead to deregulation of the metabolic adaptation of cells to hypoxia, inhibition of the DNA repair processes and overall pathological changes in gene expression. In this review, we will address the TCA cycle mutations leading to the development of PPGL, and we will discuss the relevance of these mutations for the transformation of neural crest-derived cells and potential therapeutic approaches based on the emerging knowledge of underlying molecular alterations.
Targeting Palbociclib-Resistant Estrogen Receptor-Positive Breast Cancer Cells via Oncolytic Virotherapy
Authors: Lypova Nadiia , Lanceta Lilibeth , Gipson Alana , Vega Stephanie , Garza-Morales Rodolfo , McMasters Kelly , Chesney Jason , Gomez-Gutierrez Jorge , Imbert-Fernandez Yoannis
Published: May 2019

While clinical responses to palbociclib have been promising, metastatic breast cancer remains incurable due to the development of resistance. We generated estrogen receptor-positive (ER+) and ER-negative (ER−) cell line models and determined their permissiveness and cellular responses to an oncolytic adenovirus (OAd) known as Ad5/3-delta24. Analysis of ER+ and ER− palbociclib-resistant cells revealed two clearly distinguishable responses to the OAd. While ER+ palbociclib-resistant cells displayed a hypersensitive phenotype to the effects of the OAd, ER− palbociclib-resistant cells showed a resistant phenotype to the OAd. Hypersensitivity to the OAd in ER+ palbociclib-resistant cells correlated with a decrease in type I interferon (IFN) signaling, an increase in viral entry receptor expression, and an increase in cyclin E expression. OAd resistance in ER− palbociclib-resistant cells correlated with an increase in type I IFN signaling and a marked decrease in viral entry receptor. Using the OAd as monotherapy caused significant cytotoxicity to both ER+ and ER− palbociclib-sensitive cell lines. However, the addition of palbociclib increased the oncolytic activity of the OAd only in ER+ palbociclib-sensitive cells. Our studies provide a mechanistic base for a novel anti-cancer regimen composed of an OAd in combination with palbociclib for the treatment of ER+ breast cancer.
Developing Picornaviruses for Cancer Therapy
Authors: McCarthy Cormac , Jayawardena Nadishka , Burga Laura N. , Bostina Mihnea
Published: May 2019

Oncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families, including Picornaviridae, have been shown to have anticancer activity. Picornaviruses are small icosahedral non-enveloped, positive-sense, single-stranded RNA viruses infecting a wide range of hosts. They possess several advantages for development for cancer therapy: Their genomes do not integrate into host chromosomes, do not encode oncogenes, and are easily manipulated as cDNA. This review focuses on the picornaviruses investigated for anticancer potential and the mechanisms that underpin this specificity.
The Vav GEF Family: An Evolutionary and Functional Perspective
Authors: Rodríguez-Fdez Sonia , Bustelo Xosé R.
Published: May 2019

Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the genomes of many species has revealed that this protein family originated in choanozoans, a group of unicellular organisms from which animal metazoans are believed to have originated from. Since then, the Vav family underwent expansions and reductions in its members during the evolutionary transitions that originated the agnates, chondrichthyes, some teleost fish, and some neoaves. Exotic members of the family harboring atypical structural domains can be also found in some invertebrate species. In this review, we will provide a phylogenetic perspective of the evolution of the Vav family. We will also pay attention to the structure, signaling properties, regulatory layers, and functions of Vav proteins in both invertebrate and vertebrate species.
Reply to Comment—Osteonecrosis of the Jaw in Myeloma Patients Receiving Denosumab or Zoledronic Acid. Comment on Pivotal Trial by Raje et al. Published in Lancet Oncology
Authors: Raje Noopur , Terpos Evangelos , Jandial Danielle D.
Published: May 2019

We read the comment by Fusco et al [...]
A Robust Semi-Blind Receiver for Joint Symbol and Channel Parameter Estimation in Multiple-Antenna Systems
Authors: Du Jianhe , Han Meng , Hua Yan , Chen Yuanzhi , Lin Heyun
Published: May 2019

For multiple-antenna systems, the technologies of joint symbol and channel parameter estimation have been developed in recent works. However, existing technologies have a number of problems, such as performance degradation and the large cost of prior information. In this paper, a tensor space-time coding scheme in multiple-antenna systems was considered. This scheme allowed spreading, multiplexing, and allocating information symbols associated with multiple transmitted data streams. We showed that the received signal was formulated as a third-order tensor satisfying a Tucker-2 model, and then a robust semi-blind receiver was developed based on the optimized Levenberg–Marquardt (LM) algorithm. Under the assumption that the instantaneous channel state information (CSI) is unknown at the receiving end, the proposed semi-blind receiver jointly estimates the information symbol and channel parameters efficiently. The proposed receiver had a better estimation performance compared with existing semi-blind receivers, and still performed well when the channel became strongly correlated. Moreover, the proposed semi-blind receiver could be extended to the multi-user massive multiple-input multiple-output (MIMO) system for joint symbol and channel estimation. Computer simulation results were shown to demonstrate the effectiveness of the proposed receiver.
Erratum: Li, C.P.; Duan, L.C.; Tan, S.C., et al. Damage Model and Numerical Experiment of High-Voltage Electro Pulse Boring in Granite. Energies 2019, 12, 727
Authors: Li Changping , Duan Longchen , Tan Songcheng , Chikhotkin Victor , Fu Wenpeng
Published: May 2019

The authors wish to make the following corrections to this paper [...]
Influence of Sampling Delay on the Estimation of Lithium-Ion Battery Parameters and an Optimized Estimation Method
Authors: Jiang Bing , Chen Zeqi , Chen Feifan
Published: May 2019

The equivalent-circuit model (ECM) is widely used in online estimating the parameters and states of lithium-ion batteries. However, the sampling delay between the voltage and current of a battery is generally overlooked, which is unavoidable in a modular battery management system (BMS) and would lead to wrong results in the estimation of battery parameters and states. In this paper, with the first-order resistor–capacitor (RC) model as our battery model, we analyze the influence mechanism of sampling delay and then propose an optimized method for online estimating battery parameters. The mathematical model derived from the first-order RC model and the approximation method of first-order derivative are optimized. The recursive least squares (RLS) algorithm is used for identifying the parameters of the model. In order to verify the proposed method, a modular battery test system with high sampling frequency and high synchronization accuracy is developed. The experiment results indicate that the sampling delay would cause the estimation process to fluctuate, and the optimized method effectively improves the tolerance range of sampling delay.
Psycho-Physiological Stress Recovery in Outdoor Nature-Based Interventions: A Systematic Review of the Past Eight Years of Research
Authors: Corazon Sus Sola , Sidenius Ulrik , Poulsen Dorthe Varning , Gramkow Marie Christoffersen , Stigsdotter Ulrika Karlsson
Published: May 2019

Background: In modern, urban daily life, natural environments are increasingly recognized as an important resource for stress recovery and general well-being. Aim: the present review aims to provide an overview and synthesis of the past eight years’ research into the psycho-physiological effects of outdoor nature-based interventions, related to stress recovery. Method: a structured search was performed in seven databases, returning 5618 articles. Removal of duplicates and initial screening gave a total of 95 studies. After full text reading, 36 studies were included in the assessment. Results: most of the psychological outcomes were related to different emotional measures. The synthesis of the results points towards outdoor, nature-based exposure having a positive effect on different emotional parameters, related to stress relief. The studies into physiological measures showed more equivocal results. Conclusion: the research, conducted over the past eight years, into outdoor, nature-based exposure has now attained a sound evidence base for psychological and especially emotional effects, but the evidence base for physiological effects within this timeframe shows a great degree of heterogeneity. Limitations: interpretation of the results is limited by the review only covering the past eight years’ research on the subject.
Local Housing Characteristics Associated with Early Childhood Development Outcomes in Australian Disadvantaged Communities
Authors: Villanueva Karen , Badland Hannah , Tanton Robert , Katz Ilan , Brinkman Sally , Lee Ju-Lin , Woolcock Geoffrey , Giles-Corti Billie , Goldfeld Sharon
Published: May 2019

Disadvantaged communities tend to have poorer early childhood development outcomes. Access to safe, secure, and stable housing is a well-known social determinant of health but there is a need to examine key features of neighbourhood housing that reduce early childhood development inequities. The 2012 Australian Early Development Census (AEDC), a population-wide measure of early childhood development, and the Australian Bureau of Statistics Socio-economic Index for Areas Index of Relative Socio-economic Disadvantage were used to select fourteen disadvantaged local communities in five Australian states and territories based on those performing better (off-diagonal), or as expected (on-diagonal) on the AEDC relative to their socio-economic profile. Between 2015–2017, qualitative and quantitative housing data were collected in the local communities. In total, 87 interviews with stakeholders, 30 focus groups with local service providers and parents, and Australian Census dwelling information were analysed. A comparative case study approach was used to examine differences in housing characteristics (e.g., public housing, density, affordability, and tenure) between disadvantaged local communities performing ‘better than expected’ and ‘as expected’ on early childhood development. Perceived better housing affordability, objectively measured housing tenure (ownership) and perceived and objectively measured lower-density public housing were housing characteristics that emerged as points of difference for disadvantaged local communities where children had relatively better early childhood development outcomes. These characteristics are potential modifiable and policy sensitive housing levers for reducing early childhood development inequities.
Key Decision Makers and Actors in Selected Newborn Care Practices: A Community-Based Survey in Northern Uganda
Authors: Mukunya David , Nankabirwa Victoria , Ndeezi Grace , Tumuhamye Josephine , Tongun Justin Bruno , Kizito Samuel , Napyo Agnes , Achora Vincentina , Odongkara Beatrice , Arach Agnes Anna , Tylleskar Thorkild , Tumwine James K
Published: May 2019

Knowledge of key decision makers and actors in newborn care is necessary to ensure that health interventions are targeted at the right people. This was a cross-sectional study carried out in Lira district, Northern Uganda. Multivariable logistic regression was used to determine factors associated with mothers being the key decision maker regarding where to give birth from and when to initiate breastfeeding. Fathers were the key decision makers on the place of birth (54.3%, n = 505) and on whether to seek care for a sick newborn child (47.7%, n = 92). Grandmothers most commonly bathed the baby immediately after birth (55.5%, n = 516), whereas mothers and health workers were common decision makers regarding breastfeeding initiation. Predictors for a mother being the key decision maker on the place of birth included: Mother having a secondary education (AOR 1.9: 95% C.I (1.0–3.6)) and mother being formally employed (AOR 2.0: 95% (1.5–2.9)). Mothers, fathers, grandmothers, health-workers, and traditional birth attendants were the most influential in the selected newborn care practices. Programs that aim to promote newborn care need to involve husbands, grandmothers, and health workers in addition to mothers.
The Effect of Dissolved Organic Matter (DOM) on the Release and Distribution of Endocrine-Disrupting Chemicals (Edcs) from Sediment under Hydrodynamic Forces, A Case Study of Bisphenol A (BPA) and Nonylphenol (NP)
Authors: Ding Jue , Cheng Yu , Hua Zulin , Yuan Cong , Wang Xiaoju
Published: May 2019

Endocrine-disrupting chemicals (EDCs) that exist in the aquatic system bring severe environmental risks. In this study, we investigate the dissolved organic matter (DOM) effect on the release and distribution of EDCs under varied hydrodynamic conditions. A water chamber mesocosm was designed to simulate the hydrodynamic forces in a shallow lake. The contents of bisphenol A (BPA) and nonylphenol (NP) in colloid-bound and soluble phases were measured under four increasing hydrodynamic intensities that were 5%, 20%, 50%, and 80% of the critical shear stress. The total BPA and NP contents in overlying water grew linearly with the hydrodynamic intensity (R2 = 0.997 and 0.987), from 108.28 to 415.92 ng/L of BPA and 87.73 to 255.52 ng/L of NP. The exponential relationships of EDC content and hydrodynamic intensity in soluble phase (R2 = 0.985 of BPA and 0.987 of NP) and colloid phase (R2 = 0.992 of BPA and 0.995 of NP) were also detected. The DOM concentrations in colloid-bound phase (cDOM) and in soluble phase (sDOM) were measured and the linear relationships with BPA content (R2 = 0.967 of cDOM and 0.989 of sDOM) and NP content (R2 = 0.978 of cDOM and 0.965 of sDOM) were detected. We analyzed the ratio (αDOM) of sDOM and cDOM that grew logarithmically with the hydrodynamic intensity (R2 = 0.999). Moreover, the ratio (αEDCs) of BPA and NP contents in soluble and colloid-bound phases varied differently with αDOM. The results suggested that BPA tended to be in the soluble phase and NP tended to be in the colloid-bound phase due to the increasing value of αDOM.
miR-27a-5p Attenuates Hypoxia-induced Rat Cardiomyocyte Injury by Inhibiting Atg7
Authors: Zhang Jinwei , Qiu Wanling , Ma Jideng , Wang Yujie , Hu Zihui , Long Keren , Wang Xun , Jin Long , Tang Qianzi , Tang Guoqing , Zhu Li , Li Xuewei , Shuai Surong , Li Mingzhou
Published: May 2019

Acute myocardial infarction (AMI) is an ischemic heart disease with high mortality worldwide. AMI triggers a hypoxic microenvironment and induces extensive myocardial injury, including autophagy and apoptosis. MiRNAs, which are a class of posttranscriptional regulators, have been shown to be involved in the development of ischemic heart diseases. We have previously reported that hypoxia significantly alters the miRNA transcriptome in rat cardiomyoblast cells (H9c2), including miR-27a-5p. In the present study, we further investigated the potential function of miR-27a-5p in the cardiomyocyte response to hypoxia, and showed that miR-27a-5p expression was downregulated in the H9c2 cells at different hypoxia-exposed timepoints and the myocardium of a rat AMI model. Follow-up experiments revealed that miR-27a-5p attenuated hypoxia-induced cardiomyocyte injury by regulating autophagy and apoptosis via Atg7, which partly elucidated the anti-hypoxic injury effects of miR-27a-5p. Taken together, this study shows that miR-27a-5p has a cardioprotective effect on hypoxia-induced H9c2 cell injury, suggesting it may be a novel target for the treatment of hypoxia-related heart diseases.
The Role of Heme Oxygenase 1 in the Protective Effect of Caloric Restriction against Diabetic Cardiomyopathy
Authors: Waldman Maayan , Nudelman Vadim , Shainberg Asher , Zemel Romy , Kornwoski Ran , Aravot Dan , Peterson Stephen J. , Arad Michael , Hochhauser Edith
Published: May 2019

Type 2 diabetes mellitus (DM2) leads to cardiomyopathy characterized by cardiomyocyte hypertrophy, followed by mitochondrial dysfunction and interstitial fibrosis, all of which are exacerbated by angiotensin II (AT). SIRT1 and its transcriptional coactivator target PGC-1α (peroxisome proliferator-activated receptor-γ coactivator), and heme oxygenase-1 (HO-1) modulates mitochondrial biogenesis and antioxidant protection. We have previously shown the beneficial effect of caloric restriction (CR) on diabetic cardiomyopathy through intracellular signaling pathways involving the SIRT1–PGC-1α axis. In the current study, we examined the role of HO-1 in diabetic cardiomyopathy in mice subjected to CR. Methods: Cardiomyopathy was induced in obese diabetic (db/db) mice by AT infusion. Mice were either fed ad libitum or subjected to CR. In an in vitro study, the reactive oxygen species (ROS) level was determined in cardiomyocytes exposed to different glucose levels (7.5–33 mM). We examined the effects of Sn(tin)-mesoporphyrin (SnMP), which is an inhibitor of HO activity, the HO-1 inducer cobalt protoporphyrin (CoPP), and the SIRT1 inhibitor (EX-527) on diabetic cardiomyopathy. Results: Diabetic mice had low levels of HO-1 and elevated levels of the oxidative marker malondialdehyde (MDA). CR attenuated left ventricular hypertrophy (LVH), increased HO-1 levels, and decreased MDA levels. SnMP abolished the protective effects of CR and caused pronounced LVH and cardiac metabolic dysfunction represented by suppressed levels of adiponectin, SIRT1, PPARγ, PGC-1α, and increased MDA. High glucose (33 mM) increased ROS in cultured cardiomyocytes, while SnMP reduced SIRT1, PGC-1α levels, and HO activity. Similarly, SIRT1 inhibition led to a reduction in PGC-1α and HO-1 levels. CoPP increased HO-1 protein levels and activity, SIRT1, and PGC-1α levels, and decreased ROS production, suggesting a positive feedback between SIRT1 and HO-1. Conclusion: These results establish a link between SIRT1, PGC-1α, and HO-1 signaling that leads to the attenuation of ROS production and diabetic cardiomyopathy. CoPP mimicked the beneficial effect of CR, while SnMP increased oxidative stress, aggravating cardiac hypertrophy. The data suggest that increasing HO-1 levels constitutes a novel therapeutic approach to protect the diabetic heart. Brief Summary: CR attenuates cardiomyopathy, and increases HO-1, SIRT activity, and PGC-1α protein levels in diabetic mice. High glucose reduces adiponectin, SIRT1, PGC1-1α, and HO-1 levels in cardiomyocytes, resulting in oxidative stress. The pharmacological activation of HO-1 activity mimics the effect of CR, while SnMP increased oxidative stress and cardiac hypertrophy. These data suggest the critical role of HO-1 in protecting the diabetic heart.
Pretransplant Cardiac Evaluation Using Novel Technology
Authors: Hemu Mohamad , Zimmerman Allison , Kalra Dinesh , Okwuosa Tochukwu
Published: May 2019

Hematopoietic stem-cell transplantation (HSCT) is a complex procedure that has been increasingly successful in treating malignant and nonmalignant conditions. Despite its effectiveness, it can be associated with potentially life-threatening adverse effects. New onset heart failure, ischemic disease, and arrhythmias are among the most notable cardiovascular complications post-HSCT. As a result, appropriate cardiac risk stratification prior to transplant could result in decreased morbidity and mortality by identifying patients with a higher probability of tolerating possible toxicities associated with HSCT. In this review, we aim to discuss the utility of cardiac screening using novel modalities of imaging technology in the pre-HSCT phase.
Expression of Glypican 3 Is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes
Authors: Rahbari Mohammad , Pecqueux Mathieu , Aust Daniela , Stephan Holger , Tiebel Oliver , Chatzigeorgiou Antonios , Tonn Torsten , Baenke Franziska , Rao Venkatesh , Ziegler Nicole , Greif Helena , Lin Kuailu , Weitz Juergen , Rahbari Nuh Nabi , Kahlert Christoph
Published: May 2019

Exosomes are nano-sized membranous vesicles of endosomal origin that carry nucleic acids, lipids and proteins. The cargo of exosomes is cell origin specific and the release of these exosomes and uptake by an acceptor cell is seen as a vital element of cell-cell communication. Here, we sought to investigate the diagnostic and prognostic value of the expression of glypican 3 (GPC3) on primary gastro-esophageal adenocarcinoma (GEA) tissue (tGPC3) and corresponding serum exosomes (eGPC3). Circulating exosomes were extracted from serum samples of 49 patients with GEA and 56 controls. Extracted exosomes were subjected to flow cytometry for the expression of eGPC3 and GPC3 expression on primary GEA tissue samples was determined by immunohistochemistry and correlated to clinicopathological parameters. We found decreased eGPC3 levels in GEA patients compared to healthy controls (p < 0.0001) and high tGPC3 expression. This was significantly associated with poor overall survival (high vs. low eGPC3: 87.40 vs. 60.93 months, p = 0.041, high vs. low tGPC3: 58.03 vs. 84.70 months, p = 0.044). Cox regressional analysis confirmed tGPC3 as an independent prognostic biomarker for GEA (p = 0.02) and tGPC3 expression was validated in two independent cohorts. Our findings demonstrate that eGPC3 and tGPC3 can be used as potential diagnostic and prognostic biomarkers for GEA.
Studies on Pitting Corrosion of Al-Cu-Li Alloys Part I: Effect of Li Addition by Microstructural, Electrochemical, In-situ, and Pit Depth Analysis
Authors: Lei Xiaowei , Saatchi Alireza , Ghanbari Elmira , Dang Runze , Li Wenzhe , Wang Nan , Macdonald Digby D.
Published: May 2019

To analyze the effect of lithium and microstructure on the pitting corrosion behavior of aluminum alloys, three types of aluminum alloys were studied via scanning electron microscopy, transmission electron microscopy, electrochemical polarization, and by immersion tests coupled with in-situ observation of pitting and statistical analysis of pit depths measured by surface profilometry. It was found that, with increasing lithium content, the resistance to pitting corrosion was enhanced and the passive range was enlarged. In-situ observation revealed that the development of pitting corrosion exhibited three stages, including an initial slow nucleation stage (Stage I), a fast development stage (Stage II), and a stabilized growth stage (Stage III). Higher lithium content contributed to shorter time periods of Stages I and II, resulting in faster pitting evolution and a higher number of pits. However, the pits were generally shallower for the specimen with the highest lithium content, which is in agreement with the results of the electrochemical analysis.
CO Adsorption Performance of CuCl/Activated Carbon by Simultaneous Reduction–Dispersion of Mixed Cu(II) Salts
Authors: Xue Cailong , Hao Wenming , Cheng Wenping , Ma Jinghong , Li Ruifeng
Published: May 2019

CO is a toxic gas discharged as a byproduct in tail gases from different industrial flue gases, which needs to be taken care of urgently. In this study, a CuCl/AC adsorbent was made by a facile route of physically mixing CuCl2 and Cu(HCOO)2 powder with activated carbon (AC), followed by heating at 533 K under vacuum. The samples were characterized by X-ray powder diffraction (XRD), inductively coupled plasma optical emission spectrometry (ICP-OES), N2 adsorption/desorption, and scanning electron microscopy (SEM). It was shown that Cu(II) can be completely reduced to Cu(I), and the monolayer dispersion threshold of CuCl on AC support is 4 mmol·g−1 AC. The adsorption isotherms of CO, CO2, CH4, and N2 on CuCl/AC adsorbents were measured by the volumetric method, and the CO/CO2, CO/CH4, and CO/N2 selectivities of the adsorbents were predicted using ideal adsorbed solution theory (IAST). The obtained adsorbent displayed a high CO adsorption capacity, high CO/N2, CO/CH4, and CO/CO2 selectivities, excellent ad/desorption cycle performance, rapid adsorption rate, and appropriate isosteric heat of adsorption, which made it a promising adsorbent for CO separation and purification.
Diameter of Carbon Nanotube-Directed Self-Assembly of Amphiphilic Block Copolymers
Authors: Wang Zihao , Tao Susu , Chu Yanyan , Xu Xiaoyan , Tan Qinggang
Published: May 2019

The cooperative self-assembly of nanoparticles and amphiphilic block copolymers has attracted increasing interests as it offers effective routes to achieve nanocomposite supramolecular structures with desired structure and properties. The incorporation of nanoparticles usually tunes the self-assembly structure of block copolymers, as the copolymer–nanoparticle interactions may change the relative volume ratio of hydrophobic block/hydrophilic block copolymers. It should be noted that the micro-size length and the strong nonpolar feature of carbon nanotubes (CNTs) may cause the block copolymer–CNT interactions to differ from the the block copolymer–nanoparticle interactions. Herein, we show that the diameter of CNTs and the copolymer/CNT ratio have a profound effect on the self-assembly behavior of amphiphilic block copolymers. Upon the addition of carboxylated multi-walled carbon nanotubes (c-MWCNTs, diameter <8 nm,) to the methoxy polyethylene glycol-poly (D,L-lactic acid) (MPEG-PDLLA) solution, it is difficult to observe the c-MWCNTs directly in TEM images. However, it has been found that they form supramolecular nanocomposite structures with MPEG-PDLLA. Moreover, these supramolecular structures transform from core–shell spherical micelles into rod-like micelles and then into large composite aggregates with the increase of the c-MWCNT addition. However, in the case of the addition of c-MWCNTs with a diameter of 30–50 nm, the dispersed c-MWCNTs and spherical core–shell micelles could be observed simultaneously in the TEM images at a low c-MWCNT addition, and then the micelle structure disappeared and only well-dispersed c-MWNTs were observed in TEM images at a high c-MWCNT addition. A possible model was proposed to explain the rule of CNTs participating in the formation of copolymer/CNT nanocomposite structures. It was also shown that as-prepared copolymer/CNT supramolecular nanocomposites could be used as drug carriers, enabling the adjustment of the drug loading and release time.
Study on the Product Characteristics of Pyrolysis Lignin with Calcium Salt Additives
Authors: Cui Yong , Wang Wenliang , Chang Jianmin
Published: May 2019

This study investigated and compared the product characteristics of pyrolysis lignin under different catalytic effects resulting from various calcium salts. The pyrolysis of lignin was conducted in a fixed-bed reactor with calcium salt additives, which included CaCl2, Ca(OH)2, and Ca(HCOO)2. The compositions of gas and bio-oil were detected using gas chromatography/mass spectrometry (GC/MS). The characterizations of chars were examined using Brunauer–Emmett–Teller (BET) surface area and scanning electron microscopy (SEM). The results indicate that all three types of calcium salts helped to promote bio-oil yield and inhibit gas and char from forming. Regarding the composition of gas products, calcium salt additives increased the concentrations of H2 and CH4 while decreasing the concentration of CO. In addition, calcium salt additives facilitated the formation of phenol and alkyl-phenols in bio-oil, but reduced the yields of guaiacol and vanillin, in the order CaCl2 < Ca(OH)2 < Ca(HCOO)2. Furthermore, when compared with the addition of CaCl2, the chars prepared by the addition of Ca(OH)2 and Ca(HCOO)2 had relatively higher BET surface areas. In conclusion, Ca(HCOO)2 had the greatest positive influence in regard to the product quality of lignin pyrolysis whilst also elevating the yield of value-added chemicals in bio-oils.
Improved Tensile Ductility by Severe Plastic Deformation for Nano-Structured Metallic Glass
Authors: Dong Yue , Liu Suya , Biskupek Johannes , Cao Qingping , Wang Xiaodong , Jiang Jian-Zhong , Wunderlich Rainer , Fecht Hans-Jörg
Published: May 2019

The effect of severe plastic deformation by high-pressure torsion (HPT) on the structure and plastic tensile properties of two Zr-based bulk metallic glasses, Zr55.7Ni10Al7Cu19Co8.3 and Zr64Ni10Al7Cu19, was investigated. The compositions were chosen because, in TEM investigation, Zr55.7Ni10Al7Cu19Co8.3 exhibited nanoscale inhomogeneity, while Zr64Ni10Al7Cu19 appeared homogeneous on that length scale. The nanoscale inhomogeneity was expected to result in an increased plastic strain limit, as compared to the homogeneous material, which may be further increased by severe mechanical work. The as-cast materials exhibited 0.1% tensile plasticity for Zr64Ni10Al7Cu19 and Zr55.7Ni10Al7Cu19Co8.3. Following two rotations of HPT treatment, the tensile plastic strain was increased to 0.5% and 0.9%, respectively. Further testing was performed by X-ray diffraction and by differential scanning calorimetry. Following two rotations of HPT treatment, the initially fully amorphous Zr55.7Ni10Al7Cu19Co8.3 exhibited significantly increased free volume and a small volume fraction of nanocrystallites. A further increase in HPT rotation number did not result in an increase in plastic ductility of both alloys. Possible reasons for the different mechanical behavior of nanoscale heterogeneous Zr55.7Ni10Al7Cu19Co8.3 and homogeneous Zr64Ni10Al7Cu19 are presented.
Industrial Ceramic Brick Drying in Oven by CFD
Authors: Araújo Morgana de Vasconcellos , Pereira Antonildo Santos , Oliveira Jéssica Lacerda de , Brandão Vanderson Alves Agra , Brasileiro Filho Francisco de Assis , Silva Rodrigo Moura da , Lima Antonio Gilson Barbosa de
Published: May 2019

The drying process is a step of ceramic brick production which requires the control of process variables to provide a final product with a porous uniform structure, reducing superficial and volumetric defects and production costs. Computational fluid dynamics (CFD) is an important tool in this process control, predicting the drying physical phenomenon and providing data that improve the industrial efficiency production. Furthermore, research involving CFD brick drying has neglected the effects of oven parameters, limiting the analysis only to the bricks. In this sense, the aim of this work is to numerically study the hot air-drying process of an industrial hollow ceramic brick in an oven at 70 °C. The results of the water mass and temperature distributions inside the brick, as well as moisture, temperature, velocity and pressure fields of the oven drying air at different process times are shown, analyzed and compared with experimental data, presenting a good agreement.
Characterization of Titanium Nanotube Reinforced Cementitious Composites: Mechanical Properties, Microstructure, and Hydration
Authors: Jee Hyeonseok , Park Jaeyeon , Zalnezhad Erfan , Jeong Keunhong , Woo Seung Min , Seok Seungwook , Bae Sungchul
Published: May 2019

In recent years, nano-reinforcing technologies for cementitious materials have attracted considerable interest as a viable solution for compensating the poor cracking resistance of these materials. In this study, for the first time, titanium nanotubes (TNTs) were incorporated in cement pastes and their effect on the mechanical properties, microstructure, and early-age hydration kinetics was investigated. Experimental results showed that both compressive (~12%) and flexural strength (~23%) were enhanced with the addition of 0.5 wt.% of TNTs relative to plain cement paste at 28 days of curing. Moreover, it was found that, while TNTs accelerated the hydration kinetics of the pure cement clinker phase (C3S) in the early age of the reaction (within 24 h), there was no significant effect from adding TNTs on the hydration of ordinary Portland cement. TNTs appeared to compress the microstructure by filling the cement paste pore of sizes ranging from 10 to 100 nm. Furthermore, it could be clearly observed that the TNTs bridged the microcracks of cement paste. These results suggested that TNTs could be a great potential candidate since nano-reinforcing agents complement the shortcomings of cementitious materials.
Characterizing the Neuroprotective Effects of S/B Remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) in Spinal Cord Injury
Authors: Tu Tsung-Hsi , Liou Dann-Ying , Lin Di-You , Yang Hsin-Chun , Chen Ching-Jung , Huang Ming-Chao , Huang Wen-Cheng , Tsai May-Jywan , Cheng Henrich
Published: May 2019

The main causes of dysfunction after a spinal cord injury (SCI) include primary and secondary injuries that occur during the first minutes, hours, to days after injury. This treatable secondary cascade provides a window of opportunity for delivering therapeutic interventions. An S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) has anti-inflammatory, cytoprotective, and anticarcinogenic effects in liver or neurodegenerative diseases. The present work examined the effect of S/B on injured spinal cord neurons in cultures and in vivo. S/B effectively reduced peroxide toxicity and lipopolysaccharide stimulation in both spinal cord neuron/glial and microglial cultures with the involvement of PKC and HSP70. The effect of S/B was further conducted in contusive SCI rats. Intraperitoneal injections of S/B to SCI rats preserved spinal cord tissues and effectively attenuated microglial activation. Consistently, S/B treatment significantly improved hindlimb functions of SCI rats. In the acute stage of injury, S/B treatment markedly reduced the levels of ED1 expression and lactate and had a tendency to decrease lipid peroxidation. Taken together, we demonstrated long-term hindlimb restoration alongside histological improvements with systemic S/B remedy treatment in a clinically relevant model of contusive SCI. Our findings highlight the potential of an S/B remedy for acute therapeutic intervention after SCI.
Detection of Ampicillin-Resistant E. coli Using Novel Nanoprobe-Combined Fluorescence In Situ Hybridization
Authors: Lee Wang Sik , Lee Soohyun , Kang Taejoon , Ryu Choong-Min , Jeong Jinyoung
Published: May 2019

Antibiotic-resistant bacteria present a global threat because the infections they cause are difficult to treat. Therefore, it is highly important to develop advanced methods for the identification of antibiotic resistance gene in the virulent bacteria. Here, we report the development of novel nanoprobes for fluorescence in situ hybridization (FISH) and the application of the nanoprobe to the detection of ampicillin-resistant Escherichia coli. The nanoprobe for FISH was synthesized by the modified sol–gel chemistry and the synthesized nanoprobe provided strong fluorescent signals and pH stability even under natural light condition. For the double-identification of bacteria species and ampicillin-resistance with a single probe in situ, the nanoprobes were conjugated to the two kinds of biotinylated probe DNAs; one for E. coli-species specific gene and the other for a drug-resistant gene. By using the nanoprobe-DNA conjugants, we successfully detected the ampicillin-resistant E. coli through the FISH technique. This result suggests the new insight into light stable FISH application of the nanoprobe for a pathogenic antibiotic-resistance bacterium.
Application of a Molybdenum and Tungsten Disulfide Coating to Improve Tribological Properties of Orthodontic Archwires
Authors: Gracco Antonio , Dandrea Martina , Deflorian Flavio , Zanella Caterina , De Stefani Alberto , Bruno Giovanni , Stellini Edoardo
Published: May 2019

Coatings incorporating nanoparticles of molybdenum and tungsten disulfide (MoS2 and WS2)—known for their lubricating properties—are applied to orthodontic stainless steel wires to verify if there is an improvement in terms of tribological properties during the sliding of the wire along the bracket. To simulate in vitro sliding of the wire along the bracket and evaluate friction 0.019 × 0.025 inches orthodontic stainless steel (SS) wires were subjected to the application, by electrodeposition, of Ni, Ni + MoS2, and Ni + WS2. The samples produced were analyzed with scanning electron microscopy and assessment of resistance to bending. Thirty-two test conditions have been analyzed, arising from the combination of four types of coatings (SS bare wires and strings with three types of coating), two types of self-ligating bracket (Damon Q, Ormco and In-Ovation R, GAC International), two bracket-wire angles (0° and 5°), two environments (dry and wet). Analyses carried out on the samples show acceptable coatings incorporating MoS2 and WS2 and a resistance of coatings after a minimum bending. In “dry conditions” a statistically significant decrease in friction occurs for wires coated with MoS2 and WS2 if associated with the In-Ovation bracket. In “wet conditions” this decrease is observed only in isolated test conditions. Analysis of the wires after sliding tests show little wear of the applied coatings. Nanoparticles are acceptable and similar in their behavior. Improvements in terms of friction are obtained pairing coatings incorporating MoS2 and WS2 with the In-Ovation bracket in dry conditions.
Iron Deficiency and Iron Homeostasis in Low Birth Weight Preterm Infants: A Systematic Review
Authors: Moreno-Fernandez Jorge , Ochoa Julio J. , Latunde-Dada Gladys O. , Diaz-Castro Javier
Published: May 2019

Iron is an essential micronutrient that is involved in many functions in humans, as it plays a critical role in the growth and development of the central nervous system, among others. Premature and low birth weight infants have higher iron requirements due to increased postnatal growth compared to that of term infants and are, therefore, susceptible to a higher risk of developing iron deficiency or iron deficiency anemia. Notwithstanding, excess iron could affect organ development during the postnatal period, particularly in premature infants that have an immature and undeveloped antioxidant system. It is important, therefore, to perform a review and analyze the effects of iron status on the growth of premature infants. This is a transversal descriptive study of retrieved reports in the scientific literature by a systematic technique. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were adapted for the review strategy. The inclusion criteria for the studies were made using the PICO (population, intervention, comparison, outcome) model. Consequently, the systematic reviews that included studies published between 2008–2018 were evaluated based on the impact of iron status on parameters of growth and development in preterm infants.