36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO
Authors: Bloch Michael J. , Kirtane Ajay J. , Azizi Michel , Mahfoud Felix , Basile Jan , Daemen Joost , Saxena Manish , Thackeray Lisa , McGuire Maureen , Claude Lisa , Schmieder Roland E. ,   On behalf of the RADIANCE-HTN Investigators, Wang Yale , Skeik Nedaa , Bae Richard , McMeans Amy , Goldman JoAnne , Peterson Rose , Jenkins James Stephen , Tutor Isabelle , Harrison Michael , Penning Angel , Devireddy Chandan , Lea Janice , Fiebach Amanda , Merlin Claudia , Rader Florian , Dohad Suhail , Tran Anne , Bhatia Kirin , Fisher Naomi D. L. , Sobieszczyk Piotr , Halliday Ian , Munson Tay , Lindsey Jason , Laster Steven , Bunte Mathew , Hart Anthony , King Dana , Hall Jamie , Sanghvi Kintur , Krathen Courtney , Lewis Luot , Willitts Ashley , Todoran Thomas , Basile Jan , Awkar Anthony , Palmer Casey , Tecklenburg Anna , Schindler John , Pacella John , Muldoon Matthew , Albright MaryJo , Nicholson Tracy , Flack John , Chami Youseff , Hafiz Abdul Moiz , Starkey Emily , Adams Kristal , Bernardo Nelson , Veis Judith , Hashim Hayder , Singh Suman , Whitman Donna , Stouffer Rick , Hinderliter Alan , Allen Meghan , Scholl Tatum , Fong Pete , Gainer James , Crook Sherron , Hatchcock Ellen , Cohen Debbie , Giri Jay , Kobayashi Taisei , Neubauer Robin , Naidu Suveeksha , Kirtane Ajay J. , Radhakrishnan Jai , Batres Candido , Edwards Suzanne , Khuddus Matheen , Zentko Suzanne , Touchton Abby , Roberson Marti , Bloch Michael J. , Akinapelli Abhilash , English Lisa , Neumann Bridget , Mendelsohn Farrel , Brantley Hutton , Cawthon Thomas , DeRamus Susan , Wade Wesley , Fishman Robert , Tuohy Edward , LeBlanc Jessica , McCurry Tina , Krishnaswamy Amar , Laffin Luke , Bajzer Christopher , Boros Marilyn , Branche Monica , Abraham Josephine , Abraham Anu , Stijleman Inge , Hsi David , Martin Scott , Portnay Edward , Fiebach Maryann , Garavito Carolina , Adams Todd , Teklinski Andrew , Leech Adam , Drilling Patrick , Tulik Lynda , Benzuly Keith , Paparello James , Fintel Dan , Ramirez Haydee , Kats Lauren , Huang Paul , Biswas Santanu , Risher Serena , Pratt Kristina , Ibebuogu Uzoma , Johnson Karen , Cushman William , Jones Lisa , Jackson Leigh , Landers David , Pasala Tilak , Salazer Thomas , Canino Peter , Arakelian Patricia , Yang Yi-Ming , Khaliq Asma , Weinberg Mitchell , Abetu Yihenew , Gulliver Alana , Reilly J. P. , Garasic Joseph , Chugh Atul , Bertolet Barry , Go Brian , Gallapudi Raghava , Cohn Joel , Rogers Kevin , Saxena Manish , Mathur Anthony , Jain Ajay , Balawon Armida , Zongo Oliver , Topham Christine , Sharp Andrew , Anderson Richard , Thompson Elizabeth , Spiro Nikki , Hodges Elizabeth , Holder Jaqueline , Ellam Timothy , Bagnall Alan , Jackson Ralph , Bridgett Victoria , Wilson Peter , Das Neelanjan , Doulton Timothy , Loader David , Hector Gemma , Levy Terry , Bent Clare , Kodoth Vivek , Horler Stephanie , Nix Sara , Robinson Nicholas , Al-Janabi Firas , Sayer Jeremy , Iyer Sudha Ganesh , Redman Emily , Ramirez Jonaifah , Padmanabhan Sandosh , Sharif Faisal , Alhmoudi Aishah , Lunardi Mattia , Coen Eileen , Glynn Nicola , Mahfoud Felix , Lauder Lucas , Kulenthiran Saarraaken , Koch Christina , Wachter Angelika , Schmieder Roland , Schmid Axel , Kannenkeril Dennis , Heinritz Ulrike , Endres-Frohlich Kerstin , Lurz Philipp , Rommel Karl , Fengler Karl , Petzold Martin , Büttner Margit , Weil Joachim , Agdirlioglu Tolga , Köllner Tanja , Stephan Jeannine , Dagkonakis Nikolaos , Hamann Frank , Ettl Ute , Petzsche Ulrike , Reimer Peter , Hausberg Martin , Hinrichs Ralf , Di Ponio-Voit Isabella , Lutz Matthias , Gosse Philippe , Cremer Antoine , Papadopoulos Panteleimon , Gaudissard Julie , Maire Florent , Azizi Michel , Sapoval Marc , Livrozet Marine , Regrag Asma , Paquet Valerie , Delsart Pascal , Hennicaux Justin , Sommeville Coralie , Bertrand Fabien , Daemen Joost , Lafeber Melvin , Zeijen Victor , Ruiter Amo , Huijskens Elisabeth , van Ramshorst Jan , Xaplanteris Panagiotis , Briki Rachid , de Hemptinne Quentin , Pascal Severine , Renard Katty , Lefebvre Pascal , Ferdinande Bert , Iglesias Juan F. , Ehert Georg , Gallego Laetitia , Dobretz Kevin , Bottone Sylviane , Costello Josh , Krathan Courtney , McElvarr Andrew , Reilly John , Jenkins Stephen , Cash Michael , Williams Shannon , Jarvis Maria , Laffer Cheryl , Robbins Mark , Maddel Sarita , Ducey Maryanne , Rose Suzanne , DelMastro Elizabeth , Bangalore Sripal , Williams Stephen , Cabos Stanley , Alvarez Carolina Rodriguez , Powers Eric , Hodskins Emily , Paladugu Vijay , Wells Bryan , Kim Hyun-Min , Rashid Mohammad , Owan Theophilus , Lavasani Iran , Neilson Hailey , Calhoun David , McElderry Thomas , Maddox William , Oparil Suzanne , Kinder Sheila , Garasic Joseph , Drachman Doug , Zusman Randy , Rosenfield Kenneth , Do Danny , O’Meara James , Barb Ilie , Foster Abby , Boyette Alice , Jay Desmond , Schwartz Robert , Goldman Jo Anne , Goldman Jessie , Ledley Gary , Katof Nancy , Potluri Srinivasa , Ward Scott Biedermann Jacquelyn , White Megan , Mauri Laura , Sobieszczky Piotr , Smith Alex , Aseltine Laura , Pauley Eric , Wade Tyrone , Zidar David , Shishehbor Mehdi , Effron Barry , Costa Marco , Semenec Terence , Roongsritong Chanwit , Nelson Priscilla , Cohen Debbie , Giri Jay , Neubauer Robin , Vo Thu , Chugh Atul R. , Huang Pei-Hsiu , Jose Powell , Jones Michael , Saxena Manish , Lobo Melvin D. , Mathur Anthony , Jain Ajay , Balawon Armida , Zongo Olivier , Levy Terry , Bent Clare , Beckett David , Lakeman Nicki , Kennard Sarah , Sharp Andrew , D’Souza Richard J. , Statton Sarah , Wilkes Lindsay , Anning Christine , Sayer Jeremy , Iyer Sudha Ganesh , Robinson Nicholas , Sevillano Annaliza , Ocampo Madelaine , Gerber Robert , Faris Mohamad , Marshall Andrew John , Sinclair Janet , Pepper Hayley , Davies Justin , Chapman Neil , Burak Paula , Carvelli Paula , Jadhav Sachin , Quinn Jane , Rump Lars Christian , Stegbauer Johannes , Schimmöller Lars , Potthoff Sebastian , Schmid Claudia , Roeder Sylvia , Hafer Lukas , Mahfoud Felix , Böhm Michael , Ewen Sebastian , Kulenthiran Saarraaken , Wachter Angelika , Koch Christina , Fengler Karl , Rommel Karl-Philipp , Trautmann Kai , Schmieder Roland E. , Ott Christian , Schmid Axel , Uder Michael , Heinritz Ulrike , Fröhlich-Endres Kerstin , Genth-Zotz Sabine , Kämpfner Denise , Grawe Armin , Höhne Johannes , Kaesberger Bärbel , von zur Mühlen Constantin , Wolf Dennis , Welzel Markus , Heinrichs Gudrun , Trabitzsch Barbara , Trillaud Hervé , Cornu Erika , Fouassier David , Lorthioir Aurélien , Paquet Valérie , Pathak Atul , Honton Benjamin , Cottin Marianne , Petit Frédéric , Lantelme Pierre , Berge Constance , Courand Pierre-Yves , Langevin Fatou , Longere Benjamin , Ledieu Guillaume , Pontana François , Feyz Lida , Ruiter Arno , Huyskens Elisabeth , Blankestijn Peter , Voskuil Michiel , Rittersma Zwaantina , Dolmans Helma , Kroon A. A. , van Zwam W. H. , Vranken Jeannique , de Haan Claudia , Persu Alexandre , Renkin Jean , Maes Frédéric , Beauloye Christophe , Lengelé Jean-Philippe , Huyberechts Dominique , Bouvier Anne , Witkowski Adam , Januszewicz Andrzej , Kądziela Jacek , Prejbisj Aleksander , Hering Dagmara , Ciecwierz Dariusz , Jaguszewski Milosz J. , Owczuk Radoslaw , Victor Ronald , Walsh Courtney , Williams Jonathan , Aggarwal Sandeep , Biedermann Scott , Sayer Jeremy , Iyer Sudha Ganesh , Robinson Nicholas , Edroos Sadat Ali , Patel Amit , Beckett David , Davies Justin , Chapman Neil , Shin Matthew Shun , Howard James , Sharp Andrew S. P. , Joseph Anil , D’Souza Richard , Gerber Robert , Faris Mohamad , Marshall Andrew John , Elorz Cristina , Lurz Philipp , Höllriegel Robert , Fengler Karl , Rommel Karl-Philipp , Böhm Michael , Ewen Sebastian , Lucic Jelena , Schmieder Roland E. , Ott Christian , Uder Michael , Rump Christian , Stegbauer Johannes , Kröpil Patric 
Published: September 2024

Endovascular ultrasound renal denervation (uRDN) reduced blood pressure (BP) compared to sham at 2 months in patients with resistant hypertension in the multicenter, blinded, randomized, sham-controlled RADIANCE-HTN TRIO trial. This analysis evaluates longer-term outcomes of patients randomized to uRDN. Patients with resistant hypertension to a 3-drug combination pill were randomized to uRDN (n = 69) or sham (n = 67). From 2-5 months, patients followed a standardized anti-hypertensive medication (AHM) titration protocol. At 6 months, patients were unblinded and received AHM per standard of care. In the uRDN group, 71% (49/69) completed 36-month follow-up. Screening office BP was 159/103 on 3.9 AHM. Baseline office BP on the single-pill combination was 153/99 mmHg. At 36 months, office BP changed by −14.5 ± 26.1/−9.0 ± 14.8 mmHg from screening (p < 0.001 for both) and −8.0 ± 24.5/−5.0 ± 14.6 mmHg from baseline (p = 0.007; p = 0.022) on 3.7 AHM. The efficacy of uRDN was durable to 36 months in patients with resistant hypertension with no safety concerns.