bluuebunny/crossref_metadata_2025 huggingface dataset:
Dysregulation of Synaptic Signaling Genes Is Involved in Biology of Uterine Leiomyoma
Authors: Krsteski Jovan , Gorenjak Mario , But Igor , Pakiž Maja , Potočnik Uroš
Published: July 2021

Uterine leiomyomas are tumors, which are hormone driven and originate from the smooth muscle layer of the uterine wall. In addition to known genes in leiomyoma pathogenesis, recent approaches also highlight epigenetic malfunctions as an important mechanism of gene dysregulation. RNA sequencing raw data from pair-matched normal myometrium and fibroid tumors from two independent studies were used as discovery and validation sets and reanalyzed. RNA extracted from normal myometrium and fibroid tumors from 58 Slovenian patients was used as independent confirmation of most significant differentially expressed genes. Subsequently, GWA data from leiomyoma patients were used in order to identify genetic variants at epigenetic marks. Gene Ontology analysis of the overlap of two independent RNA-seq analyses showed that NPTX1, NPTX2, CHRM2, DRD2 and CACNA1A were listed as significant for several enriched GO terms. All five genes were subsequently confirmed in the independent Slovenian cohort. Additional integration and functional analysis showed that genetic variants in these five gene regions are listed at a chromatin structure and state, predicting promoters, enhancers, DNase hypersensitivity and altered transcription factor binding sites. We identified a unique subgroup of dysregulated synaptic signaling genes involved in the biology and pathogenesis of leiomyomas, adding to the complexity of tumor biology.
Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis
Authors: Maglione Alessandro , Zuccalà Miriam , Tosi Martina , Clerico Marinella , Rolla Simona
Published: July 2021

As a complex disease, Multiple Sclerosis (MS)’s etiology is determined by both genetic and environmental factors. In the last decade, the gut microbiome has emerged as an important environmental factor, but its interaction with host genetics is still unknown. In this review, we focus on these dual aspects of MS pathogenesis: we describe the current knowledge on genetic factors related to MS, based on genome-wide association studies, and then illustrate the interactions between the immune system, gut microbiome and central nervous system in MS, summarizing the evidence available from Experimental Autoimmune Encephalomyelitis mouse models and studies in patients. Finally, as the understanding of influence of host genetics on the gut microbiome composition in MS is in its infancy, we explore this issue based on the evidence currently available from other autoimmune diseases that share with MS the interplay of genetic with environmental factors (Inflammatory Bowel Disease, Rheumatoid Arthritis and Systemic Lupus Erythematosus), and discuss avenues for future research.
Molecular Phylogenetic Analysis of the AIG Family in Vertebrates
Authors: Huang Yuqi , Sun Minghao , Zhuang Lenan , He Jin
Published: July 2021

Androgen-inducible genes (AIGs), which can be regulated by androgen level, constitute a group of genes characterized by the presence of the AIG/FAR-17a domain in its protein sequence. Previous studies on AIGs demonstrated that one member of the gene family, AIG1, is involved in many biological processes in cancer cell lines and that ADTRP is associated with cardiovascular diseases. It has been shown that the numbers of AIG paralogs in humans, mice, and zebrafish are 2, 2, and 3, respectively, indicating possible gene duplication events during vertebrate evolution. Therefore, classifying subgroups of AIGs and identifying the homologs of each AIG member are important to characterize this novel gene family further. In this study, vertebrate AIGs were phylogenetically grouped into three major clades, ADTRP, AIG1, and AIG-L, with AIG-L also evident in an outgroup consisting of invertebrsate species. In this case, AIG-L, as the ancestral AIG, gave rise to ADTRP and AIG1 after two rounds of whole-genome duplications during vertebrate evolution. Then, the AIG family, which was exposed to purifying forces during evolution, lost or gained some of its members in some species. For example, in eutherians, Neognathae, and Percomorphaceae, AIG-L was lost; in contrast, Salmonidae and Cyprinidae acquired additional AIG copies. In conclusion, this study provides a comprehensive molecular phylogenetic analysis of vertebrate AIGs, which can be employed for future functional characterization of AIGs.
Recommended Procedures to Assess Critical State Locus from Triaxial Tests in Cohesionless Remoulded Samples
Authors: da Fonseca António Viana , Cordeiro Diana , Molina-Gómez Fausto
Published: July 2021

The critical state theory is a robust conceptual framework for the characterisation of soil behaviour. In the laboratory, triaxial tests are used to assess the critical state locus. In the last decades, the equipment and testing procedures for soil characterisation, within the critical state framework, have advanced to obtain accurate and reliable results. This review paper summarises and describes a series of recommended laboratory procedures to assess the critical state locus in cohesionless soils. For this purpose, results obtained in the laboratory from different cohesionless soils and triaxial equipment configurations are compiled, analysed and discussed in detail. The procedures presented in this paper reinforce the use of triaxial cells with lubricated end platens and an embedded connection piston into the top-cap, together with the verification of the full saturation condition and the measurement end-of-test water content—preferable using the soil freezing technique. The experimental evidence and comparison between equipment configurations provide relevant insights about the laboratory procedures for obtaining a reliable characterisation of the critical state locus of cohesionless geomaterials. All the procedures recommended herein can be easily implemented in academic and commercial geotechnical laboratories.
Perceived Stigma as a Contextual Barrier to Early Uptake of HIV Testing, Treatment Initiation, and Disclosure; the Case of Patients Admitted with AIDS-Related Illness in a Rural Hospital in South Africa
Authors: Madiba Sphiwe , Ralebona Evelyn , Lowane Mygirl
Published: July 2021

We explored the extent to which perceived HIV-related stigma influences the disclosure and concealment of HIV status to family among adult patients hospitalised for AIDS-related illness, and described reports of negative responses and enacted stigma following disclosure. We conducted interviews with a purposeful sample of 28 adult patients in a rural South African hospital. Data analysis was deductive and inductive and followed the thematic approach. We found evidence of delayed HIV diagnosis and initiation of treatment. There was delayed and selective disclosure as well as concealment of the HIV-positive status. The disclosure was delayed for months or even years. During that time, there was active concealment of the HIV status to avoid stigma from family, friends, and community. When disclosure occurred, there was selective disclosure to close family members who would keep the secret and respond favorably. Although the participants disclosed mostly to close family, some of their post-disclosure experiences included incidents of enacted stigma and discrimination. The fear of perceived stigma and self-stigma influenced the active concealment of their HIV status from others. Continuous concealment of one’s HIV status and delayed disclosure limit the opportunities for support and care. There is a need to take into consideration the interaction between HIV-related stigma and disclosure to develop disclosure-counselling strategies in primary health care settings.
The Correlations between Horizontal and Vertical Peripheral Refractions and Human Eye Shape Using Magnetic Resonance Imaging in Highly Myopic Eyes
Authors: Kuo Hui-Ying , Hsiao John Ching-Jen , Chen Jing-Jie , Lee Chi-Hung , Chuang Chun-Chao , Sun Han-Yin
Published: July 2021

The aim of this study was to determine the relationship between relative peripheral refraction and retinal shape by 2-D magnetic resonance imaging in high myopes. Thirty-five young adults aged 20 to 30 years participated in this study with 16 high myopes (spherical equivalent < −6.00 D) and 19 emmetropes (+0.50 to −0.50 D). An open field autorefractor was used to measure refractions from the center out to 60° in the horizontal meridian and out to around 20° in the vertical meridian, with a step of 3 degrees. Axial length was measured by using A-scan ultrasonography. In addition, images of axial, sagittal, and tangential sections were obtained using 2-D magnetic resonance imaging. The highly myopic group had a significantly relative peripheral hyperopic refraction and showed a prolate ocular shape compared to the emmetropic group. The highly myopic group had relative peripheral hyperopic refraction and showed a prolate ocular form. Significant differences in the ratios of height/axial (1.01 ± 0.02 vs. 0.94 ± 0.03) and width/axial (0.99 ± 0.17 vs. 0.93 ± 0.04) were found from the MRI images between the emmetropic and the highly myopic eyes (p < 0.001). There was a negative correlation between the retina’s curvature and relative peripheral refraction for both temporal (Pearson r = −0.459; p < 0.01) and nasal (Pearson r = −0.277; p = 0.011) retina. For the highly myopic eyes, the amount of peripheral hyperopic defocus is correlated to its ocular shape deformation. This could be the first study investigating the relationship between peripheral refraction and ocular dimension in high myopes, and it is hoped to provide useful knowledge of how the development of myopia changes human eye shape.
The Impact of Training in Transgender Care on Healthcare Providers Competence and Confidence: A Cross-Sectional Survey
Authors: Burgwal Aisa , Gvianishvili Natia , Hård Vierge , Kata Julia , Nieto Isidro García , Orre Cal , Smiley Adam , Vidić Jelena , Motmans Joz
Published: July 2021

All studies to date demonstrate a lack of access to care for transgender people. A few educational efforts in providing care to transgender people have been successful. However, one challenge in administering training is that there is almost no research on the need of healthcare providers (HCP) to acquire knowledge, as well as on the effect of training on their level of competence and confidence in working with transgender people. Results from an online survey of a convenience sample of HCP across four different European countries (N = 810) showed that 52.7% reported experiences with some form of training on transgender people. The mean confidence level for all HCP (with or without training) in working with transgender people was 2.63, with a significant effect of training on confidence. 92.4% of HCP believed that training would raise their competence, and this belief was significantly higher among HCP with training experience, HCP working in Serbia and Sweden and/or among those HCP who belong to a sexual minority group. General practitioners had the lowest confidence levels of all professions involved. The study provided strong support for the use of training in improving healthcare conditions for transgender people, not only to raise awareness among HCP, but also to increase knowledge, competence and confidence levels of HCP in working with transgender people.
Who Is the Most Vulnerable to Anxiety at the Beginning of the COVID-19 Outbreak in China? A Cross-Sectional Nationwide Survey
Authors: Liu Bei , Han Bingfeng , Zheng Hui , Liu Hanyu , Zhao Tianshuo , Wan Yongmei , Cui Fuqiang
Published: July 2021

(1) Background: The COVID-19 pandemic has not only changed people’s health behavior, but also induced a psychological reaction among the public. Research data is needed to develop scientific evidence-driven strategies to reduce adverse mental health effects. The aims of this study are to evaluate the anxiety reaction of Chinese people and the related determinants during the earliest phase of the COVID-19 outbreak in China. Evidence from this survey will contribute to a targeted reference on how to deliver psychological counseling service in the face of outbreaks. (2) Methods: A cross-sectional, population-based online survey was conducted from 28 January to 5 February 2020 using an open online questionnaire for people aged 18 years or above, residing in China and abroad. The socio-demographic information of the respondents was collected, and anxiety scores were calculated. A direct standardization method was used to standardize anxiety scores and a general linear model was used to identify associations between some factors (e.g., sex, age, education, etc.) and anxiety scores. (3) Results: A total of 10,946 eligible participants were recruited in this study, with a completion rate of 98.16% (10,946/11,151). The average anxiety score was 6.46 ± 4.12 (total score = 15); women (6.86 ± 4.11) scored higher than men (5.67 ± 4.04). The age variable was inversely and significantly associated with the anxiety score (β = −2.12, 95% CI: −2.47–−1.78). People possessing higher education (β = 1.15, 95% CI: 0.88–1.41) or a higher awareness of cognitive risk (β = 4.89, 95% CI: 4.33–5.46) reported higher levels of anxiety. There was a close association between poor subjective health and anxiety status (β = 2.83, 95% CI: 2.58–3.09). With the increase of confidence, the anxiety of the population exhibited a gradual decline (β = −2.45, 95% CI: −2.77–−2.13). (4) Conclusion: Most people were vulnerable to anxiety during the earliest phase of the COVID-19 outbreak in China. Younger women, individuals with high education, people with high cognitive risk and subjective poor health were vulnerable to anxiety during the epidemic. In addition, increasing confidence in resisting this pandemic is a protective determinant for individuals to develop anxiety. The findings suggest that policymakers adopt psychosocial interventions to reduce anxiety during the pandemic.
Effects of Runner Removal and Partial Defoliation on the Growth and Yield Performance of ‘Favori’ Everbearing Strawberry Plants
Authors: Sønsteby Anita , Woznicki Tomasz L. , Heide Ola M.
Published: July 2021

It is not known to what degree growth and fruit yield are source-limited in everbearing strawberry plants. The growth and yield performance effect of bi-weekly removal of all runners and/or one or two leaves during the cropping season of tunnel-grown ‘Favori’ everbearing strawberry plants was determined. Plants were grown on a table-top system in an open plastic tunnel under natural light conditions in Norway from May to October. Removal of runners and leaves was bi-weekly from 5 June until 25 September. Fruits were harvested from 5 July to 7 October. Bi-weekly runner removal increased total and marketable yield and number and size of fruits, while increasing leaf thinning had the opposite effects. However, none of the treatments affected the fruit number and yield of the first fruiting flush. The treatments did not affect realization of the yield potential of the plants at planting, whereas the continued floral initiation and fruit growth were enhanced by runner removal. Increasing leaf thinning had the opposite effects. Both floral initiation and fruit growth in heavily flowering and fruiting everbearing strawberry are source-limited owing to the high fruit/leaf ratio of such plants.
Assessing Health Resources Equipped with Hemodynamic Rooms in the Portuguese-Spanish Borderland: Cross-Border Cooperation Strategies as a Possible Solution
Authors: Gómez José Manuel Naranjo , Castanho Rui Alexandre , Cabezas Fernández José , Loures Luís
Published: July 2021

Portugal and Spain share one of the greatest European borderland areas. This fact has direct impacts on a large territory and consequently on the communities’ living in it. Still, even if the border areas represent an essential fraction of the territory, planning policies have not resulted in specific cooperation programs that could enable sharing general leisure and recreation assets and infrastructures and collaboration in critical domains—i.e., the case of the health sector. The present study aims to assess the territorial accessibility to the hemodynamic rooms by the potential population of the Spanish-Portuguese transition areas that may suffer an acute myocardial infarction. Contextually, this study employed a spatial interaction model based on the three-step floating catchment area method (method-3SFCA). By applying these methods, it was possible to develop a map of accessibility to health infrastructures equipped with hemodynamics rooms on both sides of the border that may answer the Spanish-Portuguese border populations’ needs. Besides, while granting valuable information for decision-makers regarding the need to develop new infrastructures to guarantee that even considering cross border cooperation, everyone gets access to a hemodynamics room within the critical intervention period.
Optimization and Prediction Techniques for Self-Healing and Self-Learning Applications in a Trustworthy Cloud Continuum
Authors: Alonso Juncal , Orue-Echevarria Leire , Osaba Eneko , López Lobo Jesús , Martinez Iñigo , Diaz de Arcaya Josu , Etxaniz Iñaki
Published: July 2021

The current IT market is more and more dominated by the “cloud continuum”. In the “traditional” cloud, computing resources are typically homogeneous in order to facilitate economies of scale. In contrast, in edge computing, computational resources are widely diverse, commonly with scarce capacities and must be managed very efficiently due to battery constraints or other limitations. A combination of resources and services at the edge (edge computing), in the core (cloud computing), and along the data path (fog computing) is needed through a trusted cloud continuum. This requires novel solutions for the creation, optimization, management, and automatic operation of such infrastructure through new approaches such as infrastructure as code (IaC). In this paper, we analyze how artificial intelligence (AI)-based techniques and tools can enhance the operation of complex applications to support the broad and multi-stage heterogeneity of the infrastructural layer in the “computing continuum” through the enhancement of IaC optimization, IaC self-learning, and IaC self-healing. To this extent, the presented work proposes a set of tools, methods, and techniques for applications’ operators to seamlessly select, combine, configure, and adapt computation resources all along the data path and support the complete service lifecycle covering: (1) optimized distributed application deployment over heterogeneous computing resources; (2) monitoring of execution platforms in real time including continuous control and trust of the infrastructural services; (3) application deployment and adaptation while optimizing the execution; and (4) application self-recovery to avoid compromising situations that may lead to an unexpected failure.
Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction
Authors: Nishigaki Akisato , Ichikawa Yuhuko , Ezaki Minoru , Yamamoto Akitaka , Suzuki Kenji , Tachibana Kei , Kamon Toshitaka , Horie Shotaro , Masuda Jun , Makino Katsutoshi , Shiraki Katsuya , Shimpo Hideto , Shimaoka Motomu , Suzuki-Inoue Katsue , Wada Hideo
Published: July 2021

Background: Acute cerebral infarction (ACI) includes cardiogenic ACI treated with anticoagulants and atherosclerotic ACI treated with antiplatelet agents. The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. Materials and Methods: The plasma sCLEC-2 and D-dimer levels were measured using the STACIA system. Results: The plasma sCLEC-2 level was significantly high in patients with ACI, especially those in patients with atherosclerotic or lacunar ACI, and plasma D-dimer levels were significantly high in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios in patients with atherosclerotic or lacunar ACI were significantly higher than those in patients with cardioembolic ACI. The plasma D-dimer levels in patients with atherosclerotic or lacunar ACI were significantly lower than those in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios were significantly higher in patients with atherosclerotic or lacunar ACI or acute myocardial infarction in comparison to patients with cardioembolic ACI or those with deep vein thrombosis. Conclusion: Using both the plasma sCLEC-2 and D-dimer levels may be useful for the diagnosis of ACI, and differentiating between atherosclerotic and cardioembolic ACI.
Yellow Pigment Powders Based on Lead and Antimony: Particle Size and Colour Hue
Authors: Capobianco Giuseppe , Agresti Giorgia , Bonifazi Giuseppe , Serranti Silvia , Pelosi Claudia
Published: July 2021

This paper reports the results of particle size analysis and colour measurements concerning yellow powders, synthesised in our laboratories according to ancient recipes aiming at producing pigments for paintings, ceramics, and glasses. These pigments are based on lead and antimony as chemical elements, that, combined in different proportions and fired at different temperatures, times, and with various additives, gave materials of yellow colours, changing in hues and particle size. Artificial yellow pigments, based on lead and antimony, have been widely studied, but no specific investigation on particle size distribution and its correlation to colour hue has been performed before. In order to evaluate the particle size distribution, segmentation of sample data has been performed using the MATLAB software environment. The extracted parameters were examined by principal component analysis (PCA) in order to detect differences and analogies between samples on the base of those parameters. Principal component analysis was also applied to colour data acquired by a reflectance spectrophotometer in the visible range according to the CIELAB colour space. Within the two examined groups, i.e., yellows containing NaCl and those containing K-tartrate, differences have been found between samples and also between different areas of the same powder indicating the inhomogeneity of the synthesised pigments. On the other hand, colour data showed homogeneity within each yellow sample and clear differences between the different powders. The comparison of results demonstrates the potentiality of the particle segmentation and analysis in the study of morphology and distribution of pigment powders produced artificially, allowing the characterisation of the lead and antimony-based pigments through micro-image analysis and colour measurements combined with a multivariate approach.
Patient Satisfaction, Functional Outcomes, and Implant Survivorship in Patients Undergoing Customized Unicompartmental Knee Arthroplasty
Authors: Pumilia Cyrus Anthony , Schroeder Lennart , Sarpong Nana O. , Martin Gregory
Published: July 2021

Customized unicompartmental knee arthroplasty (C-UKA) utilizes implants manufactured on an individual patient basis, derived from pre-operative computed tomography images in an effort to more closely approximate the natural anatomy of the knee. The outcomes from 349 medial and lateral fixed-bearing C-UKA were reviewed. Implant survivorship analysis was conducted via retrospective chart review, and follow-up analysis was conducted via a single postoperative phone call or email. The rate of follow-up was 69% (242 knees). The average age at surgery was 71.1 years and the average body mass index was 28.8 kg/m2. Seven revision arthroplasties (2.1%) had knowingly been performed at an average of 1.9 years postoperatively (range: 0.1–3.9 years), resulting in an implant survivorship of 97.9% at an average follow-up of 4.2 years (range: 0.1–8.7) and 97.9% at an average of 4.8 years (range: 2.0–8.7) when knees with less than two years of follow-up were excluded. The reasons for revision were implant loosening (one knee), infection (two knees), progression of osteoarthritis (two knees), and unknown reasons (two knees). The average KOOS, JR. interval score was 84 (SD: 14.4). Of those able to be contacted for follow-up analysis, 67% were “very satisfied,” 26% were “satisfied,” 4% were “neutral,” 2% were “dissatisfied,” and 1% were “very dissatisfied.” When asked if the knee felt “natural,” 60% responded with “always,” 35% responded with “sometimes,” and 5% responded with “never.” After analyzing a large cohort of C-UKA, we found favorable rates of survivorship, satisfaction, and patient-reported functional outcomes.
Role of Lung Ultrasound in Predicting Clinical Severity and Fatality in COVID-19 Pneumonia
Authors: Skopljanac Ivan , Ivelja Mirela Pavicic , Barcot Ognjen , Brdar Ivan , Dolic Kresimir , Polasek Ozren , Radic Mislav
Published: July 2021

Background: Lung ultrasound (LUS) is a useful imaging method for identifying COVID-19 pneumonia. The aim of this study was to explore the role of LUS in predicting the severity of the disease and fatality in patients with COVID-19. Methods: This was a single-center, follow-up study, conducted from 1 November 2020, to 22 March 2021. The LUS protocol was based on the assessment of 14 lung zones with a total score up to 42, which was compared to the disease severity and fatality. Results: A total of 133 patients with COVID-19 pneumonia confirmed by RT-PCR were enrolled, with a median time from hospital admission to lung ultrasound of one day. The LUS score was correlated with clinical severity at hospital admission (Spearman’s rho 0.40, 95% CI 0.24 to 0.53, p < 0.001). Patients with higher LUS scores were experiencing greater disease severity; a high flow nasal cannula had an odds ratio of 1.43 (5% CI 1.17–1.74) in patients with LUS score > 29; the same score also predicted the need for mechanical ventilation (1.25, [1.07–1.48]). An LUS score > 30 (1.41 [1.18–1.68]) and age over 68 (1.26 [1.11–1.43]) were significant predictors of fatality. Conclusions: LUS at hospital admission is shown to have a high predictive power of the severity and fatality of COVID-19 pneumonia.
Land-Use and Land-Cover Changes in Dong Trieu District, Vietnam, during Past Two Decades and Their Driving Forces
Authors: Vu Thi-Thu , Shen Yuan
Published: July 2021

Land-use and land-cover (LULC) change analyses are useful in understanding the changes in our living environments and their driving factors. Modeling changes of LULC in the future, together with the driving factors derived through analyzing the trends of past LULC changes, bring the opportunity to assess and orientate the current and future land-use policies. As the entryway of Quang Ninh province, Vietnam, Dong Trieu locale has experienced significant LULC changes during the past two decades. In this study, the spatial distribution of six Level I LULC classes, forest, cropland, orchards, waterbody, built-up, and barren land, in Dong Trieu district at 2000, 2010, and 2019 were obtained from Landsat imageries by maximum likelihood technique. The most significant changes observed over the past twenty years are a decrease of barren land (9.1%) and increases of built-up (8.1%) and orchards (6.8%). Driving factor analysis indicated that the changes of cropland and built-up were dependent on distance from road (DFR), distance from main road (DFMR), distance from urban (DFU), distance from water (DFW), elevation, slope, and population density. The changes of forest were dependent on all the driving forces listed above, except DFMR. The orchards mainly appeared near the high-population-density area. The transformation of the waterbody was affected by geography (elevation and slope) and population density. The higher the population density, the less barren the land would appear.
Urban Type Classification and Characteristic Analysis through Time-Series Environmental Changes for Land Use Management for 31 Satellite Cities around Seoul, South Korea
Authors: Kim Jin-Hyo , Kwon Oh-Sung , Ra Jung-Hwa
Published: July 2021

The objective of the present study was to determine changes in land coverage for 31 satellite cities surrounding Seoul and changes in values of MSPA (Morphological Spatial Pattern Analysis) for a time period of about 30 years (from 1988 to 2018). Cities that showed similar environmental changes were grouped utilizing a hierarchical cluster analysis. The results of this study are summarized as follows: First, as a result of analyzing changes in land coverage, urbanized areas in all 31 cities greatly increased, whereas areas of forest, grassland, farmland, wetland, etc., greatly decreased. Second, as a result of carrying out MSPA for green areas in each city, the number of Cores, Islets as stepping-stone green areas, and Branches greatly decreased. As a result of analyzing factors in cluster analysis, 12 variables were classified into four groups. After performing a cluster analysis, the 31 cities were classified into six clusters. Cluster-6 showed the biggest decrease in wetland areas. These results could be used as basic data for establishing differentiated environmental policies for clusters of cities that show similar environmental changes, and for establishing policy priorities that break away from uniform environmental policies at the local level.
On the Relationship between Frequency, Features, and Markedness in Inflection: Experimental Evidence from Russian Nouns
Authors: Parker Jeff
Published: July 2021

Markedness has a long tradition in linguistics as a way to describe linguistic asymmetries. In this paper, I investigate an argument about the necessity of markedness as a tool for capturing the structural distribution of inflectional affixes and predicting the behavioral consequences of that distribution. Based on evidence from German adjectives, Clahsen et al. argue that the number of specified features of inflectional affixes (which I argue represents a type of markedness) affects reaction times in lexical access. Affixes’ features, however, overlap with how frequently they occur. Clahsen et al. investigate only three affixes in German, leaving open questions about the relationship between the two factors and whether features are necessary as a predictor of lexical processing. In this paper, I use a larger set of inflectional affixes in Russian to test the relationship between affix features and affix frequency. I find that the two traits of affixes are correlated based on frequencies from a corpus and that in a lexical decision task, affix frequency is the better predictor of response times. My results suggest that we should question the necessity of featural markedness for explaining how inflectional structure is processed and, more generally, that both corpus and experimental data suggest a surprisingly close relationship between affix features and affix frequency.
The Mutational Robustness of the Genetic Code and Codon Usage in Environmental Context: A Non-Extremophilic Preference?
Authors: Radványi Ádám , Kun Ádám
Published: July 2021

The genetic code was evolved, to some extent, to minimize the effects of mutations. The effects of mutations depend on the amino acid repertoire, the structure of the genetic code and frequencies of amino acids in proteomes. The amino acid compositions of proteins and corresponding codon usages are still under selection, which allows us to ask what kind of environment the standard genetic code is adapted to. Using simple computational models and comprehensive datasets comprising genomic and environmental data from all three domains of Life, we estimate the expected severity of non-synonymous genomic mutations in proteins, measured by the change in amino acid physicochemical properties. We show that the fidelity in these physicochemical properties is expected to deteriorate with extremophilic codon usages, especially in thermophiles. These findings suggest that the genetic code performs better under non-extremophilic conditions, which not only explains the low substitution rates encountered in halophiles and thermophiles but the revealed relationship between the genetic code and habitat allows us to ponder on earlier phases in the history of Life.
Influence of Liquid-to-Solid and Alkaline Activator (Sodium Silicate to Sodium Hydroxide) Ratios on Fresh and Hardened Properties of Alkali-Activated Palm Oil Fuel Ash Geopolymer
Authors: Kwek Shi Ying , Awang Hanizam , Cheah Chee Ban
Published: July 2021

Malaysia is one of the largest palm oil producers in the world and its palm oil industry is predicted to generate a large amount of waste, which increases the need to modify it for sustainable reuse. The green geopolymers produced from industrial waste can be a potential substitute for cementitious binders. This type of polymer helps reduce dependency on cement, a material that causes environmental problems due to its high carbon emissions. Palm oil fuel ash (POFA) geopolymer has been widely investigated for its use as a sustainable construction material. However, there is still uncertainty regarding the total replacement of cement with POFA geopolymer as a binder. In this study, we examined the effects of different material design parameters on the performance of a POFA-based geopolymer as a building material product through iterations of mixture optimisation. The material assessed was a single raw precursor material (POFA) activated by an alkaline activator (a combination of sodium hydroxide and sodium silicate with constant concentration) and homogenised. We conducted a physical property test, compressive strength test, and chemical composition and microstructural analyses to evaluate the performance of the alkali-activated POFA geopolymer at 7 and 28 days. According to the results, the optimum parameters for the production of alkali-activated POFA paste binder are 0.6 liquid-to-solid ratio and 2.5 alkaline activator ratio. Our results show that the use of alkali-activated POFA geopolymer is technically feasible, offering a sustainable and environmentally friendly alternative for POFA disposal.
Design of Shape Memory Thermoplastic Material Systems for FDM-Type Additive Manufacturing
Authors: Quiñonez Paulina A. , Ugarte-Sanchez Leticia , Bermudez Diego , Chinolla Paulina , Dueck Rhyan , Cavender-Word Truman J. , Roberson David A.
Published: July 2021

The work presented here describes a paradigm for the design of materials for additive manufacturing platforms based on taking advantage of unique physical properties imparted upon the material by the fabrication process. We sought to further investigate past work with binary shape memory polymer blends, which indicated that phase texturization caused by the fused filament fabrication (FFF) process enhanced shape memory properties. In this work, two multi-constituent shape memory polymer systems were developed where the miscibility parameter was the guide in material selection. A comparison with injection molded specimens was also carried out to further investigate the ability of the FFF process to enable enhanced shape memory characteristics as compared to other manufacturing methods. It was found that blend combinations with more closely matching miscibility parameters were more apt at yielding reliable shape memory polymer systems. However, when miscibility parameters differed, a pathway towards the creation of shape memory polymer systems capable of maintaining more than one temporary shape at a time was potentially realized. Additional aspects related to impact modifying of rigid thermoplastics as well as thermomechanical processing on induced crystallinity are also explored. Overall, this work serves as another example in the advancement of additive manufacturing via materials development.
Acoustic Metasurface-Aided Broadband Noise Reduction in Automobile Induced by Tire-Pavement Interaction
Authors: Heo Hyeonu , Sofield Mathew , Ju Jaehyung , Neogi Arup
Published: July 2021

The primary noise sources of the vehicle are the engine, exhaust, aeroacoustic noise, and tire–pavement interaction. Noise generated by the first three factors can be reduced by replacing the combustion engine with an electric motor and optimizing aerodynamic design. Currently, a dominant noise within automobiles occurs from the tire–pavement interaction over a speed of 70–80 km/h. Most noise suppression efforts aim to use sound absorbers and cavity resonators to narrow the bandwidth of acoustic frequencies using foams. We demonstrate a technique utilizing acoustic metasurfaces (AMSes) with high reflective characteristics using relatively lightweight materials for noise reduction without any change in mechanical strength or weight of the tire. A simple technique is demonstrated that utilizes acoustic metalayers with high reflective characteristics using relatively lightweight materials for noise reduction without any change in mechanical strength or weight of the tire. The proposed design can significantly reduce the noise arising from tire–pavement interaction over a broadband of acoustic frequencies under 1000 Hz and over a wide range of vehicle speeds using a negative effective dynamic mass density approach. The experiment demonstrated that the sound transmission loss of AMSes is 2–5 dB larger than the acoustic foam near the cavity mode, at 200–300 Hz. The proposed approach can be extended to the generalized area of acoustic and vibration isolation.
Evaluation of the Ability to Accurately Produce Angular Details by 3D Printing of Plastic Parts
Authors: Mihalache Andrei Marius , Nagîț Gheorghe , Slătineanu Laurențiu , Hrițuc Adelina , Markopoulos Angelos , Dodun Oana
Published: July 2021

3D printing is a process that has become widely used in recent years, allowing the production of parts with relatively complicated shapes from metallic and non-metallic materials. In some cases, it is challenging to evaluate the ability of 3D printers to make fine details of parts. For such an assessment, the printing of samples showing intersections of surfaces with low angle values was considered. An experimental plan was designed and materialized to highlight the influence of different factors, such as the thickness of the deposited material layer, the printing speed, the cooling and filling conditions of the 3D-printed part, and the thickness of the sample. Samples using areas in the form of isosceles triangles with constant height or bases with the same length, respectively, were used. The mathematical processing of the experimental results allowed the determination of empirical mathematical models of the power-function type. It allowed the detection of both the direction of actions and the intensity of the influence exerted by the input factors. It is concluded that the strongest influence on the printer’s ability to produce fine detail, from the point of view addressed in the paper, is exerted by the vertex angle, whose reduction leads to a decrease in printing accuracy.
Collocation Methods for High-Order Well-Balanced Methods for Systems of Balance Laws
Authors: Gómez-Bueno Irene , Díaz Manuel Jesús Castro , Parés Carlos , Russo Giovanni
Published: July 2021

In some previous works, two of the authors introduced a technique to design high-order numerical methods for one-dimensional balance laws that preserve all their stationary solutions. The basis of these methods is a well-balanced reconstruction operator. Moreover, they introduced a procedure to modify any standard reconstruction operator, like MUSCL, ENO, CWENO, etc., in order to be well-balanced. This strategy involves a non-linear problem at every cell at every time step that consists in finding the stationary solution whose average is the given cell value. In a recent paper, a fully well-balanced method is presented where the non-linear problems to be solved in the reconstruction procedure are interpreted as control problems. The goal of this paper is to introduce a new technique to solve these local non-linear problems based on the application of the collocation RK methods. Special care is put to analyze the effects of computing the averages and the source terms using quadrature formulas. A general technique which allows us to deal with resonant problems is also introduced. To check the efficiency of the methods and their well-balance property, they have been applied to a number of tests, ranging from easy academic systems of balance laws consisting of Burgers equation with some non-linear source terms to the shallow water equations—without and with Manning friction—or Euler equations of gas dynamics with gravity effects.
Revisited Carmichael’s Reduced Totient Function
Authors: Belhaouari Samir Brahim , Hamdi Yassine , Hamdi Abdelouahed
Published: July 2021

The modified Totient function of Carmichael λ(.) is revisited, where important properties have been highlighted. Particularly, an iterative scheme is given for calculating the λ(.) function. A comparison between the Euler φ and the reduced totient λ(.) functions aiming to quantify the reduction between is given.
Opinion Diversity and the Resilience of Cooperation in Dynamical Networks
Authors: Miles Adam Lee , Cavaliere Matteo
Published: July 2021

Across various scenarios, individuals cooperate with others to contribute towards a shared goal and ensure self-preservation. In game theory, the act of cooperation is considered as an individual producing some form of benefit to be utilised by others, under the expectation others will return the favour. In several scenarios, individuals make use of their own information to aid with their decision about who to connect and cooperate with. However, the choice of cooperation can be taken advantage of by opportunistic defectors, which can lead to significant disruption. This paper investigates how the diversity of opinion can contribute to the structure and mechanics of a dynamical network model and to the resilience of cooperation, by utilising a computational model where individuals make use of both public and private information to implement their decision. Our results show that increasing diversity leads to more stable, less connected and less prosperous networks coupled to more frequent, but shallower information cascades. Our work generally shows that the outcome of the conflict between cooperators and cheaters strongly depends on the interplay between population structure, individual decision making and individual opinions.
The Impact of Bipolar Disorder on Couple Functioning: Implications for Care and Treatment. A Systematic Review
Authors: Azorin Jean-Michel , Lefrere Antoine , Belzeaux Raoul
Published: July 2021

If there is an abundant literature on the impact of bipolar illness on the family and/or caregivers of patients, few studies have addressed its impact on marital relationship and couple functioning. Uncovering information relating specifically to this topic may be particularly relevant due to the unusually high divorce rate among individuals with bipolar disorder. We therefore conducted a systematic literature search to evaluate the existing data on bipolar disorder and marital issues, with a special focus on the help and support that can be provided by mental health professionals in this regard. We identified quantitative studies with pre-defined outcomes as well as qualitative investigations trying to understand the experiences of partners. A total of 27 articles were included in the review. The literature was found to capture the impact of bipolar disorder on partners as well as on the marital relationship itself or the children. Bipolar illness has a negative impact on the lives of partners including self-sacrifice, caregiver burden, emotional impact, and health problems. This negative impact can be aggravated by a lack of care and a lack of information from health personnel. The negative impact on the relationship includes volatility in the relationship, stigmatization, dissatisfaction with sexual life, and lower rates of childbearing. Negative impacts are likely to favor disease relapses for the patient. Children may also be negatively impacted. However, the illness may sometimes have positive impacts such as personal evolution, strengthening relationship, or new hope and perspectives. Based on these findings, the interventions of mental health professionals should be aimed at minimizing the negative impacts while favoring the positive ones.
A Comparison of Diagnosed Skin Diseases between the Years with and without COVID-19 Pandemic
Authors: Roongpisuthipong Wanjarus , Yodla Pornchai , Klangjareonchai Theerawut
Published: July 2021

Background and Objectives: The COVID-19 pandemic has a considerable influence on public health, either directly or indirectly. We investigated outpatient skin disease diagnoses at the dermatology clinic to determine the effect of the COVID-19 pandemic on these patients. Materials and Methods: We conducted a retrospective study using the International Codes of Diseases data from the outpatient department of Dermatology clinic, Vajira hospital, Navamindradhiraj University, Bangkok, Thailand from January 2019 to June 2021. Results: A total of 20,915 patients with 34,116 skin diagnoses were included in the study. The average weekly dermatologic clinic visits remained unchanged between the years with and without COVID-19 pandemic. While the percentage of xerosis cutis, other skin infections (syphilis and parasitic infections), hair and nail disorders, pigmentary disorders, benign skin tumors and drug eruptions were significantly decreased during the COVID-19 pandemic years, the percentage of other dermatitis, fungal and viral skin infections, acne, psoriasis, urticaria, vesiculobullous and autoimmune diseases were increased. Conclusion: The COVID-19 pandemic had a minimal effect on the average weekly skin clinic visits, but the diagnosed skin diseases pattern was affected. Knowing the pattern of skin diseases may help aid hospitals to better prepare for future pandemics in securing appropriate medications and supplies and training the medical teams.
A 50-Year-Old Patient with Guillain–Barré Syndrome after COVID-19: A Case Report
Authors: Chmiela Tomasz , Rzepka Michalina , Krzystanek Ewa , Gorzkowska Agnieszka
Published: July 2021

Severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, causes acute respiratory disease (coronavirus disease 2019; COVID-19). However, the involvement of other mechanisms is also possible, and neurological complications are being diagnosed more frequently. Here, we would like to present a case of a Polish patient with Guillain–Barré syndrome (GBS), after a documented history of COVID-19: A 50-year-old man, 18 days after the onset of COVID-19 symptoms, had progressive quadriparesis preceded by 1-day sensory disturbances. Based on the clinical picture, the results of diagnostic work-up including a nerve conduction study (ENG) that revealed a demyelinating and axonal sensorimotor polyneuropathy, and cerebrospinal fluid (CSF) analysis that showed albumin–cytological dissociation, an acute inflammatory demyelinating polyneuropathy was confirmed, consistent with GBS. Upon a therapeutic plasma exchange (TPE), the patient’s condition improved. The presented case of GBS in a patient after mild COVID-19 is the first case in Poland that has supplemented those already described in the global literature. Attention should be drawn to the possibility of GBS occurring after SARS-CoV-2 infection, even when it has a mild course.