bluuebunny/crossref_metadata_2025 huggingface dataset:
Pakistan’s Role In Russia’s Greater Eurasian Partnership
Authors: Korybko Andrew , Morozov Vladimir
Published: May 2020

Connectivity is one of the key trends of the 21st century, which Russia is fully embracing with its Greater Eurasian Partnership (GEP) in order to counteract the chaotic processes unleashed throughout the course of the ongoing systemic transition from unipolarity to multipolarity. This outlook sets forth the grand strategic task of integrating with some of the former countries of the erstwhile Soviet Union through the Russian-led Eurasian Economic Union (EAEU) and then further afield with the other regions of Eurasia in order to benefit from the growing cross-supercontinental trade between Europe and Asia. President Putin declared during the second Belt & Road Initiative (BRI) Forum in April 2019 that this Chinese-led project “rimes with Russia’s idea to establish a Greater Eurasian Partnership” and that “The five EAEU member states have unanimously supported the idea of pairing the EAEU development and the Chinese Silk Road Economic Belt project”. It naturally follows that the pairing of the EAEU with BRI would involve Russia improving its connectivity with the latter’s flagship project of the China-Pakistan Economic Corridor (CPEC) in South Asia, thereby endowing Pakistan with an important role in the GEP. The rapidly improving relations between Moscow and Islamabad, as well as the peacemaking efforts undertaken by those two states and other stakeholders in Afghanistan across 2019, raise the prospect of a future trade corridor traversing through the countries between them and thus creating a new axis of Eurasian integration that would complete the first envisaged step of bringing the EAEU and BRI closer together. In pursuit of this multilaterally beneficial outcome, it’s important to explain the policymaking and academic bases behind it so as to prove the viability of this proposal.
Assessment of Gneiss-Derived Residual Soils as Materials Used in Road Pavement Structures
Authors: Oluwaniyi Olaoluwa , Fatoyinbo Imoleayo , Bello Akinola , Owoseni Joshua
Published: May 2020

Failure of highway pavement and collapse of building in basement complex of Nigeria is often related to the instability of the residual. This study evaluated the strength characteristics of gneiss-derived residual Soils as materials usable for road pavement structures. A total of eleven soil samples derived from granite gneiss were subjected to laboratory geotechnical analyses based on standard practices. The geotechnical analyses reveal the soils’ natural moisture content, specific gravity, grain sizes, consistency limits, shearing strengths, maximum dry density, and optimum moisture content. Based on AASHTO classification, the soil samples are classified as A-7-6, A-6, and A-7-5. The results of the laboratory analyses revealed that the natural moisture content and specific gravity ranged from 8.30 to 22.70% and 2.6 to 2.8 respectively. Particle size analysis reveals that the coarse contents of the soils ranged from 28.8% to 59.8% and amount of fines ranged from 40.2 to 71.2%. The liquid limit ranged from 31.3% to 68.3%, plastic limit ranged from 20% to 28.0%, plasticity index ranged from 4.8% to 38.90% and linear shrinkage ranged from 5.7 to 13.6%. The maximum dry density ranged from 1481 kg/m3to 1921 kg/m3and optimum moisture content ranged from 15.2% to 27.6%. Undrained triaxial shear strength (Cu) ranged from 43.0 Kpa to 250.3Kpa, angle of friction ranges from 11.7 to 29.30, and unconfined compressive strength ranged from 153 to 356.5Kpa. The results indicate that the residual soils are poor sub-grade and foundation materials due to their high amount of fines, linear shrinkage values, plasticity, and swelling potential, as well as low maximum dry density.
The Digital Universe
Authors: Zwolenski Matt , Weatherill Lee
Published: May 2020

The Digital Universe, which consists of all the data created by PC, Sensor Networks, GPS/WiFi Location, Web Metadata, Web-Sourced Biographical Data, Mobile, Smart-Connected Devices and Next-Generation Applications (to name but a few) is altering the way we consume and measure IT and disrupting proven business models. Unprecedented and exponential data growth is presenting businesses with new and unique opportunities and challenges. As the ‘Internet of Things’ (IoT) and Third Platform continue to grow, the analysis of structured and unstructured data will drive insights that change the way businesses operate, create distinctive value, and deliver services and applications to the consumer and to each other. As enterprises and IT grapple to take advantage of these trends in order to gain share and drive revenue, they must be mindful of the Information Security and Data Protection pitfalls that lay in wait ─ hurdles that have already tripped up market leaders and minnows alike.
Project-Based Management Technique for Radiofrequency Spectrum Planning and Allocation
Authors: Kerans Andrew , Todhunter Barrie
Published: May 2020

Spectrum Management is the regulatory action of defining the use of the radiofrequency spectrum. Often this requires the clearance of a large number of incumbent systems to make way for new technologies such as Fourth Generations Mobile Broadband (4G). While great economic benefits may be derived from the new technologies the clearance of any band will come at a cost. It is important both costs and benefits be quantified and compared. In many administrations including Australia these processes are carried out without a defined project management structure. In the first of a series of two papers the Authors combine over 40 years of radio systems and planning experience to suggest a methodology for project-based management of spectrum planning activities.
The importance of circumstance
Authors: Humphry Justine
Published: May 2020

Access to and affordability of digital technology for vulnerable and disadvantaged groups is an ongoing concern in an Australian context, however the digital needs, issues and barriers for consumers who are homeless are largely neglected in this literature. This paper presents findings from a research project on mobile phones and the internet in the lives of people experiencing homelessness and engages with some key issues of digital exclusion arising in the context of a general shift in connectivity to mobile media and the push by the Australian government to reform service provision around these changes. The paper argues for the need to recognise the ways that life situations and circumstances of hardship, such as homelessness, factor into the patterns of mobile and Internet connectivity, creating unique issues of digital access and equity. It argues for knowledge of these differences to inform digital delivery of government services and approaches to telecommunications policies and assistance programs, and puts forward a number of recommendations based on a study of 95 adults, families and young people experiencing homelessness which was carried out in Sydney and Melbourne in early 2014.
Book review of ‘Network services: QoS, Signalling, Processes’ by Harry Perros
Authors: Warfield Bob
Published: May 2020

This article reviews Networking Services: QoS, Signalling, Processes [Amazon Digital Services: ASIN BooIJFZTWC], by Harry Perros, Computer Science Department, North Carolina State University, USA; 2014, 516 pp.
Enabling Technologies for Effective Deployment of Internet of Things (IoT) Systems
Authors: Y. Khan Jamil , Chen Dong , Hulin Oliver
Published: May 2020

The demand for IoT (Internet of Things) systems that encompass cloud computing, the multitude of low power sensing and data collection electronic devices and distributed communications architecture is increasing at an exponential pace. With increasing interests from different industrial, business and social groups, in the near future it will be necessary to support massive deployment of diverse IoT systems in different geographical areas. Large scale deployment of IoT systems will introduce challenging problems for the communication designers, as the networking is one of the key enabling technologies for the IoT systems. Major challenges include cost effective network architecture, support of large area of coverage and diverse QoS (Quality of Service) requirements, reliability, spectrum requirements, energy requirements, and many other related issues. The paper initially reviews different classes of IoT applications and their communication requirements. Following the review, different communications and networking technologies that can potentially support large scale deployment of IoT systems for different industrial, business and social applications are discussed. The paper then concentrates on wireless networking technologies for IoT systems with specific focus on deployment issues. The deployment discussion concentrates on different IoT systems QoS and networking requirements, cost, coverage area and energy supply requirements. We introduce a sustainable low cost heterogeneous network design using short range radio standards such as IEEE 802.15.4/Zigbee, IEEE 802.11/WLAN that can be used to develop a wide area networks to support large number of IoT devices for various applications. Finally the paper makes some general recommendations towards sustainable network design techniques for future IoT systems that can reduce the OPEX and CAPEX requirements.
Evaluation of healing of varicose ulcers after endovenous laser ablation of great saphenous vein
Authors: Mohamed Hatem Hussein , Alshahat Beshoy Magdy , Almezaien Mamdouh Mohamed
Published: May 2020

Background: Varicose veins are permanently swollen, tortuous and elongated while standing due to back flow of blood caused by incompetent valve closure which result in venous congestion .they are of two types primary and secondary varicosities .The main symptoms are tingling, itching, pain, fatigue, a heavy feeling in the legs especially if one has to stand for a long time. Ulcers and thrombophlebitis are possible complications. The aim of this study is to assess the outcome of laser ablation of great saphenous vein on healing of varicose ulcers.Methods: A prospective study conducted at Suez Canal University Hospitals and Nasser Institute Hospital in Cairo on 20 patients complaining varicose ulcers due to incompetent saphenous femoral junction.Results: All patients had improvement in Abrdeen Varicose vein questionnaire after endovenous laser ablation (EVLA) during the first, second and third follow up visits when compared with preoperative scores. The Aberdeen Varicose vein questionnaire ranged from 8 to 18 before the procedure, with a mean of 12.11, ranged from 3 to 11 at the first follow up visit with a mean of 7.07, ranged from 2 to 10 at the second follow up visit with a mean of 4.89 and ranged from 2 to 10 at the third follow up visit with a mean of 3.85, p value is less than 0.001 compared to the pre-operative data. During the assessment of the patients of our study after 6 months of continuous follow up, we found that the healing rate of the patients who underwent laser ablation of great saphenous vein were (91.67) (p=0.769).Conclusions: EVLA of great saphenous vein leads to better wound healing rates in treating patients with varicose ulcers.
A study on assessment of postoperative complications among major abdominal surgeries using Clavien-Dindo classification
Authors: Rapaka Rohit Reddy , Reddy M. Venkata
Published: May 2020

Background: Surgical team always tries to provide consistently low incidence of major complications for patient undergoing any operation. Clavien-Dindo (CD) classification is the simplest way of reporting all complications. The main aim of this study was to test the usefulness of Clavien-Dindo classification in patients undergoing the abdominal surgery. In this study Clavien-Dindo classification has been used for assessment of postsurgical complications after major abdominal surgery.Methods: A total of 50 patients admitted to surgical wards for major abdominal surgery were evaluated through history, co-morbid condition and thorough clinical examination based on inclusion and exclusion criteria along with necessary investigations. Post-operative complications and management were recorded, and then postsurgical complication was classified based on Clavien-Dindo classification and assessed.Results: Most of the patients who developed complications were in the age group of 40-50 years. Most of the patients (32%) belonged to grade 2 complications. Serum creatinine, blood urea and post-operative stay were found to have direct relation with Clavien-Dindo grade of complications.Conclusions: The Clavien-Dindo classification represents an objective and simple way of reporting all complications in patients undergoing major abdominal surgeries and comparing the various complications between different surgeries. However, a definite statement on the clinical value of this classification system is not yet possible due to the small case number in this study, but the promising results should encourage further evaluation in larger cohort with the goal to possibly establish its validity as a standard clinical practice.
An audit to study the diagnostic yield of lymph node biopsies under local anaesthesia
Authors: Victor Coelho , Kota Albert A. , Colney Lalchandami , Roopavathana Beulah , Chase Suchita , Nayak Sukria
Published: May 2020

Background: Surgical referrals for lymph node biopsies are common, majority for diagnostic purposes. The indications and the diagnostic yield vary for different sites. We conducted an audit of the lymph node biopsies done over a period of seven months.Methods: The audit included 547 patients who underwent lymph node biopsies under local anesthesia in the department of general surgery over a seven-month period. Parameters such as overall diagnostic yield of lymph node biopsies, disease specific yield of lymph node biopsies with a primary focus on tuberculosis; site specific yield of lymph node biopsies and  referral pattern for the request for lymph node biopsies were analysed.Results: 324 samples (59.2%) yielded a definite diagnosis, which included haematological malignancy 102 (31.5%), infectious diseases 131 (40.5%), and 59 (18.5%) malignancy. The diagnostic yield of supraclavicular lymph nodes was found to be highest (72.45%) and the axillary group the lowest (39.8%). The referral pattern seen was 314 (57.4%) from General medicine, 149 (27.2%) from General Surgery, and 84 (15.4%) from Haematology. 130 (23.8%) samples were tested for tuberculosis; the highest yield, acquired from the cervical group (52.8%), lowest from the inguinal region (4%).Conclusions: Our audit revealed significant diagnostic yield of lymph node biopsies from the supraclavicular region. Majority of them were of infectious aetiology and referred from General Medicine. This study supports the introduction of co-ordinated problem-based referral and management pathways for the management of patients with enlarged superficial lymph nodes, supported by regular audits of practice.
Management of upper extremity peripheral vascular disease: a multimodality approach
Authors: Upganlawar Prasad , Rahalkar Ashwinee , Joshi Sneha , Khatri Simran
Published: May 2020

Background: It is estimated that more than 200 million people suffer from peripheral vascular disease worldwide. However very few studies are available on upper extremity vascular disease, thus making it an under diagnosed and under treated condition.Methods: In the present study we included 20 participants suffering from upper limb peripheral vascular disease and managed them with multi-modality approach involving general surgeon, interventional radiologist and vascular surgeon for medical line of management, thrombolysis and thrombo-embolectomy procedures.Results: In the present study we observed that early management of these patients with medical management, interventional radiology and embolectomy procedures helped in limb salvage. However alarmingly high number of patients (35%) landed up in amputation because of low index of suspicion and delayed referral.Conclusions: A high level of suspicion and early referral to a tertiary care centre where multi-modality facilities like interventional radiology and vascular surgeon are available should be done.
A comparative study of mammography, sonography and infrared thermography in detection of cancer in breast
Authors: Badiger Suresh , Moger Jayant
Published: May 2020

Background: Breast cancer has emerged as the commonest cancer in Indian women. In a large population country like India we need a rapid, economical, and accurate investigation to diagnose breast cancer in its earlier stage. The objective of this study was to compare the effectiveness of mammography, sonography and infrared thermography in detection of breast cancer.Methods: Patients presenting to the surgical OPD with suspicious breast lump were evaluated by infrared thermography, sonography and mammography followed by biopsy of the breast lump. Results of the all 3 above radiological modalities were compared with the histopathological biopsy for the presence of the cancer. The study was done between 1st December 2012 to 31st August 2014 in Sassoon General Hospitals attached to B. J. Government Medical College, Pune. We compared the performance of all diagnostic methods individually and in combination using the results from all patients. Statistical analysis was performed for all variables with fisher's exact test.Results: Out of 50 patients, 31 patients had malignant breast lesions and 19 patients had benign lesions on biopsy. The mammography showed higher diagnostic accuracy and specificity than ultrasonography and thermography. As an individual modality the sensitivity of the sonography was higher than mammography and thermography.Conclusions: Sonography is found to have higher sensitivity than mammography and infrared thermography but it is less specific than mammography. Mammography is found to be more specific (89.47%) than sonography and infrared thermography.
Presence of Helicobacter pylori infection in gastroduodenal perforations
Authors: T. Kemparaj , Bagur Ashika
Published: May 2020

Background: Gastroduodenal perforations constitute one of the commonest surgical emergencies encountered. Helicobacter pylori is a gram negative bacterium that has infected more than half the world’s population. The most commonly recognized manifestation of H. pylori infection in India is peptic ulcer disease. Although the relationship between H. pylori infection and peptic ulcer has been well defined, the relationship of H. pylori infection with gastroduodenal perforation is still controversial. The objective of the study was to determine the presence of H. pylori in gastroduodenal perforations.Methods: We conducted a prospective study, noting the number of cases which turned out to be positive for H. pylori in cases of gastroduodenal perforations intraoperatively, using rapid urease test.Results: Out of 100 cases of gastroduodenal perforations operated, 74% were positive for the test. Gastric perforations positive for the test were 81.4% and duodenal perforations positive for the test were 68.42%.Conclusions: There is a positive attribution between H. pylori infection and gastroduodenal perforations.
A study in cancer patients with radiotherapy assessing effectiveness of nutritional supplement and ambulation in improving fatigue and physical activity
Authors: Someshwara Rao Pallela Narayana , Vince Vincent Anil , Mabel Helen
Published: May 2020

Background: Patients receiving radiation therapy suffer from ill effects of cancer as well as the side effects of radiation therapy. In this study, we prepared a nutritional supplement therapy and ambulation plan for the patients and assessed the improvement in physical activity and decrease in fatigue.Methods: The patients who had completed at least 3 sittings of radiotherapy in the oncology ward were selected by non-probability purposive sampling method. 60 patients were divided equally into experimental and control group. In the experiment group patients were given porridge three times a day and made to walk after drinking the porridge every day for 25 days. In both groups, post test was conducted. The data obtained was analyzed using descriptive and inferential statistics.Results: All the patients in both the groups had fatigue before the intervention. After the intervention on 30th day, 7 (23.3%) patients had mild fatigue, 23 (76.70%) had moderate fatigue and there was none with severe fatigue in the experimental group. In the control group, fatigue level became severe in 3 (10.00%) patients and remained same in others. In the experimental group, significant improvement was shown in performing physical activities after the intervention. 9 (30%) showed good physical activity, 12 (40.00%) showed moderate activity after the intervention in the experimental group.Conclusions: As there was a significant reduction in the level of fatigue and improvement in the level of physical activity in the experimental group after the intervention which could be attributed to the effect of nutritional supplement therapy and ambulation.
Aquarium granuloma: a diagnosis based on history
Authors: Pereira Chirag , Tauro Leo F. , Shetty Prathvi
Published: May 2020

Mycobacterium marinum infections are rare but well described in literature. It causes an infection known as aquarium granuloma or swimming pool granuloma since its transmitted through contaminated water. We describe a case of aquarium granuloma in a male patient with skin nodules over his dominant hand whose occupational history helped clinch the diagnosis.
Dental sleep medicine: A comprehensive overview
Authors: A. Bhad Wasundhara , Baheti Nikita , J. Chavan Santosh , S. Sonwane Siddharth
Published: May 2020

With the increasing awareness of the ravages of airway disorders especially obstructive sleep apnoea (OSA) as a sleep related breathing disorder and the realization that dentist has the capability of offering possible solutions in this area, it is time to consider new aspect of dentistry as Dental sleep medicine. The concept focuses on practice of clinical dentistry aimed at achieving ideal jaw relationship, establish normal oral function and performance. The principal aspect of function and performance is airway and breathing which, in fact, is one of the most important function for humans. Altered airway and pattern of breathing could change the posture of tongue, jaws and head and lead to malocclusion. Early dental treatment has a beneficial effect not only on the teeth but establish the best possible airway at the earliest possible age. Today, dental profession is crucial and integral part of the interdisciplinary group in the management of SRBDs. This review article will guide a dentist to identify a child or adult suspected or at a risk of SRBD. Also, explain role of dentist and orthodontist in the management and treatment of the SRBDs.
Thrombotic microangiopathy after kidney transplantation: causes, clinical specifics and outcomes
Authors: Prokopenko E. I. , Shcherbakova E. O. , Kantaria R. O. , Stepanov V. A.
Published: May 2020

Background: Thrombotic microangiopathy (TMA) is a clinical and morphological phenomenon characterized by specific microvascular injury, microangiopathic hemolytic anemia, and damage of various target organs. TMA after kidney transplantation (post-renal transplant TMA) is a serious complication affecting the recipient and graft survival.

Aim: To analyze the timing, causes, specifics of the clinical course and outcomes of TMA in renal transplant recipients.

Materials and methods: This one-center study was based on a comprehensive examination and follow-up of 697 patients who had undergone 728 kidney transplantations (KT) from deceased donors in 2003–2019. Post-transplant TMA of the renal graft was confirmed morphologically in all cases.

Results: We identified 32 episodes of post-transplant TMA in 32 patients; thus, the incidence of TMA was 4.4%. All cases developed after KT de novo; no recurrent TMA was observed. TMA was systemic in 37.5% and locally renal in 62.5% of the patients. The median time to the development of post-transplant TMA was 0.55 (range, 0.1 to 51.6) months. The patients with TMA did not differ from those without by gender, age, body mass index, underlying disorders, type and duration of dialysis before KT, protocols of immunosuppressive therapy, incidence of surgical, urological, infectious, cardiovascular and oncological complications. The patients with TMA were significantly more likely to have graft rejection (25.0% vs 11.2%, p = 0.035) and a never-functioning transplant (28.1% vs 4.9%, p < 0.001). The presence of TMA negatively affected the transplantation outcomes. The cumulative 1-year graft survival in the patients without and with TMA was 91% and 44%, respectively, whereas their 5-year survival rates were 68% and 25% (p < 0.001). The leading causes of TMA were: donor pathology (31.2%), antibody-mediated rejection (28.1%), and cyclosporine/tacrolimus nephrotoxicity (21.9%); the proportion of other causes was 18.8%. A combination of TMA etiological factors was identified in 68.7% of the recipients. The recipients with of calcineurin inhibitors nephrotoxicity had a more favorable prognosis compared to those with other causes of TMA.

Conclusion: Post-renal transplant TMA is an infrequent but serious complication that worsens the graft survival and often is life-threatening for recipients. In most cases, TMA develops in the early post-operative period; however, it can occur any time thereafter. To improve the outcome of TMA, early diagnosis is necessary based on clinical suspicion and a prompt biopsy of the renal graft with suspected TMA. Treatment should be started quickly with consideration of the cause of the complication.
Marginalized centre: Wana people and the geography of power
Authors: Scalici Giorgio
Published: May 2020

The Wana of Morowali (Indonesia) are nowadays a small endangered community marginalized by the Indonesian government, world religions and the other communities in the area but, according to their own mythology, they are not the periphery of the world, but the real centre of it.

Their cosmogonic myth tells how the Wana land (Tana Taa) was the first land placed on the primordial waters and it was full of mythical power, a power that, when the land was spread around the world to create the continents, abandoned the Wana to donate wealth and power to the edge of the world: the West. This myth has a pivotal role in the Wana worldview, their categorization of the world and the power relationships in it. The Wana reverse the traditional relationship between centre and periphery, placing themselves in a powerless centre (the village or the Tana Taa) that gave all its power to a periphery (the jungle or the West) that must be explored to obtain power and knowledge.

This relationship not only expresses a clear agency in shaping the relationship of power with forces way stronger than the Wana (Government and world religions) but also creates internal hierarchies based on the access to this knowledge; granted to men and partially precluded to women due to the cultural characterizations of these genders. Indeed, the majority of shamans, called tau walia (human-spirit), are men, and they are the only one that can travel between the human and the spiritual world, obtaining a spiritual and social power.

In this article, we will see how Wana categorise the world and use religion, rituality and gender to express their agency to cope with the marginalization by the government, the world religions and the other community in the area.
Economic analysis of some agrotechnical factors in maize production - a Hungarian case study
Authors: Bai Attila , Gabnai Zoltán , Kovách Imre , Czibere Ibolya , Nagy János , Sulyok Dénes , Maloku Donika , Balogh Péter
Published: May 2020

This paper focuses on the economic and statistical evaluation of the production technology findings of the polyfactorial maize production experiments carried out between 2015-2017 at the Látókép Experiment Site of the University of Debrecen, Faculty of Agricultural and Food Sciences and Environmental Management. The examined agrotechnical factors included irrigation, previous crop, tillage, crop density, hybrid and N nutrient supply, while the effect of different crop years was taken into consideration. In addition to descriptive statistical methods, we used multivariate regression analysis during the statistical evaluation. In the course of the evaluation, we examined three models that differed in terms of tillage methods and the consideration of crop year. In our best fit model, the factors were 71% responsible for the change in yield value. We carried out efficiency and comparative analyses in the course of the economic evaluation.Averaged over the three examined years, it can be stated that nutrient supply and crop year had an outstanding effect on yield, while irrigation had a minimal effect. However, global warming may justify irrigation in the future, not only from a biological point of view, but also from an economic aspect.Ideal tillage is also greatly affected by crop year, too. Altogether, of the examined tillage systems, subsoiling proved to be the best from an economic point of view.Our investigations confirm that it is better to perform intensive farming under more favourable market conditions. The optimum of N fertilisation is probably outside of the range we examined, if the extreme changes in maize and fertiliser prices are ignored.

JEL Classification: Q16, Q12, Q13, O32
Estabelecendo o Modelo de Negócio de Incubadoras
Authors: Antunes Luiz Guilherme Rodrigues , Araújo Gustavo Sifuentes , Almeida Kassia Cristina
Published: May 2020

Devido à importância e o caráter dinâmico das incubadoras de empresas, essas organizações precisam ser gerenciadas como verdadeiras empresas. Dessa forma, o modelo de negócio é uma ferramenta gerencial importante aos gestores das incubadoras, uma vez que permite que eles alcancem os objetivos específicos e sociais dessas instituições. A partir disso, o objetivo desse artigo foi apresentar o modelo de negócio de incubadora de empresas sob a luz da literatura nacional e internacional. Para que, recorreu-se a revisão de literatura, iniciando-se com os artigos apontados por Antunes et al. (2017). Como principal resultado, obteve-se que o negócio intrínseco da incubadora pode ser dividido em duas lógicas, as dos mantenedores e das incubadas, verificadas sob seis elementos valor, clientes, receitas, processos-chave, recursos e stakeholders. Por fim, tal artigo contribui com a disseminação do modelo de negócio como uma ferramenta gerencial pertinente a essas instituições, bem com nível de análise para futuras pesquisas.
Internet das Coisas a Serviço da Defesa
Authors: Ramanho Tarso De Souza , Weiss Marcos Cesar , Zapparoli Castro Melo Vidal Augusto , Kofuji Sergio Takeo
Published: May 2020

Esse trabalho tem por objetivo propor uma sistemática de rastreamento de armamentos. Para alcançar o objetivo proposto neste estudo, optou-se pela realização de pesquisa em bases de dados e documentos referentes a armamentos de polícia e Forças Armadas, bem como busca sobre Internet das Coisas (IoT) e Sistema de Identificação por Radiofrequência (RFID). As análises foram realizadas com base na correlação da literatura encontrada com a proposta do estudo de se viabilizar o rastreamento de armamentos. Os resultados obtidos sugerem que o rastreamento de armamentos irá contribuir para a segurança e controle na aquisição de armamentos desde a sua confecção até a distribuição para o local-fim. A partir do momento em que se sabe que o Sistema RFID permite a identificação precisa de objetos e encaminhamento dessas informações para um banco de dados armazenado na Internet ou num servidor remoto, o estudo contribui não só para propor uma forma de rastreabilidade de armamentos, como também para gerar novas ideias e melhorias nessa seara, contribuindo ainda para a segurança mundial.
DERGİPARK VERİ TABANINDA YER ALAN İKTİSADİ VE İDARİ BİLİMLER FAKÜLTESİ DERGİLERİNDEKİ BÖLGESEL KALKINMA MAKALELERİ ÜZERİNE BİR İNCELEME
Authors: ÇELİKKAYA Süha
Published: May 2020

Bu araştırmanın amacı, DergiPark veri tabanında bulunan İktisadi ve İdari Bilimler Fakültesi dergilerinde yayımlanmış bölgesel kalkınma konulu çalışmaları bibliyometrik analiz yöntemiyle incelemektir. Literatürde bölgesel kalkınma politikalarına ilişkin teorik ve ampirik pek çok çalışma bulunurken, bibliyometrik herhangi bir çalışmaya rastlanmamaktadır. Bibliyometrik çalışmalar bir kavramın süreç içerisinde yaşadığı dönüşümü yansıtmak amaçlı kullanılmaktadır. Bu türdeki çalışmalar farklı araştırmaları karşılaştırma imkanı sağlamaktadır. Aynı zamanda bilimsel araştırma ve yayın politikalarının meydana getirilmesi amaçlı da bibliyometrik çalışmalardan yararlanılmaktadır. Bu kapsamda belirlenen veri tabanında yer alan 40 farklı üniversitenin dergisi taranmıştır. 1977-2018 yılları arasında araştırma kapsamındaki dergilerde bölgesel kalkınma konulu 103 adet makaleye ulaşılmıştır. Araştırmada, bölgesel kalkınma alanında değerlendirilme amaçlı olarak yazar sayıları, yazarların kurumları, yazar ünvanları, çalışmanın yayımlandığı dergiler, anahtar kelimeler, kaynak sayıları, yayın dili ve çalışmanın türü gibi veriler dikkate alınmıştır.
Maternal characteristics and pregnancy outcomes of Chinese women with infertility undergoing in vitro fertilization with embryonic cryopreservation: a retrospective cohort study
Authors: wang jingxue , liu qiwei , Deng Boer , chen fang , liu xiaowei , cheng jiumei
Published: May 2020

Background: To examine differences in the maternal characteristics and pregnancy outcomes of Chinese women with various causes of infertility who underwent in vitro fertilization(IVF) with embryonic cryopreservation treatment.Methods: This retrospective cohort study included women with various causes of infertility who used IVF. In order to reduce the research error, we deliberately removed the fresh ET cycles and ICSI cycles at the beginning, so in our data the IVF-ET method was frozen-embryo transfer.[MOU1] [MOU2] Data on demographic characteristics, medical history, laboratory tests, and delivery were reviewed. Logistic regression analysis was performed to calculate odds ratios and 95% confidence intervals for pregnancy and perinatal complications and neonatal outcomes. The multivariable model was adjusted for age, gravidity, parity, pre-pregnancy obesity, birth plurality, and history of previous caesarean section.[MOU3] Results: The IVF treatment group was divided into 5 subgroups according to infertility cause as follows: ovulation disorder, tubal disease, male infertility, endometriosis, and mixed infertility. Among singleton pregnancies, we verified that IVF with embryonic cryopreservation pregnancies are related to increased risks of adverse perinatal outcomes. Besides，compared with spontaneous pregnancies, IVF pregnancies were associated with significant increases in the rates of the following: gestational diabetes mellitus (GDM), preeclampsia, preterm preeclampsia, postpartum haemorrhage, intrahepatic cholestasis of pregnancy, preterm premature rupture of membranes, preterm birth, low birthweight, macrosomia, and neonatal intensive care unit (NICU) admission in the ovulation disorder group; GDM, placenta previa, placenta accreta, postpartum haemorrhage, macrosomia and 5-minute Apgar score ≤7 in the tubal disease group; placenta previa, small for gestational age, macrosomia and NICU admission in the endometriosis group; placenta previa and placenta accreta in the male infertility group; and GDM, placenta previa, placental abruption, chorioamnionitis, preterm birth, and 1-minute Apgar score≤7 in the mixed infertility group. Among multiple pregnancies, most of the differences that were significant in singleton pregnancies were less extensive or had disappeared.[MOU4] [MOU5] Conclusions: During the perinatal period, maternal characteristics, in particular type of infertility, appears an additional risk factor for abnormal pregnancy outcomes besides use of IVF techniques. Lower risk is found in male infertility and higher risk for ovulation disorders.[MOU6]
Neuroanatomical underpinnings of autism symptomatology in carriers and non-carriers of the 22q11.2 microdeletion
Authors: Gudbrandsen Maria , Bletsch Anke , Mann Caroline , Daly Eileen , Murphy Clodagh M , Stoencheva Vladimira , Blackmore Charlotte , Rogdaki Maria , Kushan Leila , Bearden Carrie E , Murphy Declan G.M , Craig Michael C , Ecker Christine
Published: May 2020

Background: A crucial step to understanding the mechanistic underpinnings of autism spectrum disorder (ASD), is to examine if the biological underpinnings of ASD in genetic high-risk conditions, like 22q11.2 Deletion Syndrome (22q11.2DS), are similar to those in idiopathic illness. This study aimed to examine if ASD symptomatology in 22q11.2DS is underpinned by the same – or distinct – neural systems that mediate these symptoms in non-deletion carriers. Methods: We examined vertex-wise estimates of cortical volume (CV), surface area (SA), and cortical thickness across 131 individuals between 6 and 25 years of age including (1) 50 individuals with 22q11.2DS, out of which n=25 had a diagnosis of ASD, (2) 40 non-carriers of the microdeletion with a diagnosis of ASD (i.e. idiopathic ASD), and (3) 41 typically developing (TD) controls. We employed a 2-by-2 factorial design to identify neuroanatomical variability associated with the main effects of 22q11.2DS and ASD, as well as their interaction. Further, using canonical correlation analysis (CCA), we compared neuroanatomical variability associated with the complex (i.e. multivariate) clinical phenotype of ASD between 22q11.2 deletion carriers and non-carriers. Results: The set of brain regions associated with the main effect of 22q11.2DS was distinct from the neuroanatomical underpinnings of the main effect of ASD. Moreover, significant 22q11.2DS-by-ASD interactions were observed for CV and SA in the dorsolateral prefrontal cortex, precentral gyrus, and posterior cingulate cortex, suggesting that the neuroanatomy of ASD is significantly modulated by 22q11.2DS ( p <0.01). We further established that the multivariate patterns of neuroanatomical variability associated with differences in symptom profiles significantly differed between 22q11.2 deletion carriers and non-carriers. Limitations: We employed a multicenter design to overcome single-site recruitment limitations, however, FreeSurfer derived measures of surface anatomy have been shown to be highly reliable across scanner platforms and field-strengths’. Further, we controlled for gender to address the differing distribution between idiopathic ASD individuals and the other groups. Nonetheless, the gender distribution in our sample reflects that of the respective populations, adding to the generalizability of our results. Last, we included individuals with a relatively wide age range (i.e. 6-25 years). Conclusions: Our findings indicate that neuroanatomical correlates of ASD symptomatology in carriers of the 22q11.2 microdeletion diverge from those in idiopathic ASD.
Relationship between comprehensive geriatric assessment and amyloid PET in older persons with MCI
Authors: Lauretani Fulvio , Ruffini Livia , Scarlattei Maura , Maggio Marcello
Published: May 2020

Background. The association between amyloid deposition and cognitive, behavioral and physical performance in mild cognitive impairment (MCI) due to Alzheimer's disease (AD) has been poorly investigated, especially in older persons. Methods. We studied the in vivo correlation between the amyloid deposition at Positron Emission Tomography (amyloid-PET) and the presence of memory loss, reduced executive function, physical performance and neuropsychiatric symptoms in older persons with MCI. Amyloid-PET was performed with 18F-flutemetamol and quantitatively analyzed. Results. We evaluated 48 subjects, 21 men and 27 women. We performed in each patient a comprehensive geriatric assessment (CGA) including Mini Mental State Examination (MMSE), Clock Drawing Test (CDT), Activity Daily Living (ADL), Instrumental Activity of Daily Living (IADL), Neuropsychiatric inventory (NPI) questionnaire, 15 Geriatric Depression Scale (GDS), Short Physical Performance Battery (SPPB) and Hand Grip strength. Then, each patient underwent amyloid-PET. Mean age of the enrolled subjects was 74.6 ± 7.8 years. All of these subjects showed preserved cognitive function at MMSE > 24, while 29 of 48 subjects (61.0 %) had altered CDT. Mean NPI score was 6.9 ± 5.9. The mean value of SPPB score was 9.0 ± 2.6, while the average muscle strength of the upper extremities measured by hand grip was 25.6±7.7 Kg. CT/MRI images showed cortical atrophic changes in 26 of the 48 examined subjects (54.0 %), while cerebrovascular modifications were present in 31 subjects (64.5 %). Pathological burden of amyloid deposits was detected in 25 of 48 (52.0 %) patients with a mean value of global z-score of 2.8 (subjects defined as MCI due to AD). After stratifying subjects in subclasses of clinical alterations, more probability of pathological amyloid deposition was found in subjects with impaired CDT and higher NPI score (O.R.= 3.45 [1.01-11.2], p=0.04), with both impaired CDT and low physical performance (O.R.= 5.80 [1.04-32.2], p=0.04), with altered CDT and high NPI score (O.R.=7.98 [1.38-46.0], p=0.02), and finally in those subjects with altered CDT, high NPI and low physical performance (O.R.= 5.80 [1.05-32.2], p=0.04). Conclusion. Our findings support the recent hypothesis that amyloid deposition could be associated with multiple cerebral dysfunction, mainly affecting executive, behavioral and motor abilities.
Clinical and molecular spectrum of 46, XY disorders of sex development that harbour MAMLD1 variations: Case series and review of literature
Authors: Lele Li , Fan Lijun , Gao Fenqi , Wu Di , Gong Chunxiu
Published: May 2020

Background Mastermind-like domain-containing 1 (MAMLD1) has previously been identified as a causative gene for "46, XY Disorders of Sex Development (DSD)". Recently, there has been some controversy regarding the causative role of MAMLD1 variations in DSDs. Here we describe a clinical series and review the reported cases to evaluate the role of MAMLD1 variants in children with 46, XY DSD. Cases of 46, XY DSD harbouring MAMLD1 variants from unrelated families were recruited from the Beijing Children’s Hospital in China (N = 10) or identified through a literature search (N = 26). The clinical manifestations and genetic variants of all the patients were evaluated.Results Hypospadias was the most prevalent phenotype among our 10 cases (8 out of 10 cases) and in all the previously reported ones. Central precocious puberty and isolated micropenis were observed for the first time. Among the 10 cases, nine variants were identified, including three nonsense (p.A356X, p.G152X, and p.G124X) and six missense (p.P334S, p.S662A, p.A421P,p.T992I, p.P542S, and p.A927L) variants. In silico analysis showed that the variants p.P334S, p.P542S, p.S662A, and p.A927Lmight lead to drastic changes in the interaction force of the amino acid chain and the flexibility of the spatial structure, and such changes may affect protein function.Conclusion Patients with 46, XY DSD harbouring MAMLD1variants manifest a broad spectrum of phenotypes and mostly present with hypospadias. The six novel variants reported here enrich the mutation database and contribute to our understanding of the pathogenesis of 46, XY DSD.
Proteomic analysis of Rickettsia akari proposes a 44 kDa-OMP as a potential biomarker for Rickettsialpox diagnosis
Authors: Csicsay František , Flores-Ramirez Gabriela , Zuñiga-Navarrete Fernando , Bartošová Mária , Fučíková Alena , Pajer Petr , Dresler Jiří , Škultéty Ľudovít , Quevedo-Diaz Marco Antonio
Published: May 2020

Background: Rickettsialpox is a febrile illness caused by the mite-borne pathogen Rickettsia akari. Several cases of this disease are reported worldwide. Nevertheless, the relationship between the immunogenicity of R. akari and the disease development remains poorly understood. Therefore, misdiagnosis is frequent. Our study is aimed to identify immunogenic proteins that may improve disease recognition and enhance subsequent treatment. To achieve this goal, two proteomics methodologies were applied, followed by immunoblot confirmation. Results: Three hundred and sixteen unique proteins were identified in the whole-cell extract of R. akari. The most represented protein groups were found to be those involved in translation, post-translational modifications, energy production, and cell wall development. A significant number of proteins belonged to amino acid transport and intracellular trafficking. Also, some proteins affecting the virulence were detected. In silico analysis of membrane enriched proteins revealed 25 putative outer membrane proteins containing beta-barrel structure and 11 proteins having a secretion signal peptide sequence. Using rabbit and patient sera, various immunoreactive proteins were identified from which the 44 kDa uncharacterized protein (A8GP63) has demonstrated a unique detection capability. It positively distinguished the sera of patients with Rickettsialpox from other rickettsia positive patient sera. Conclusion: Our proteomic analysis certainly contributed to the knowledge of the pathogenesis of R. akari. The result obtained may also serve as a guideline for a more accurate diagnosis of rickettsial diseases. Identified R. akari antigenic protein can be design as a unique marker of rickettsialpox and used as a target for the development of more effective treatment.
Erenumab in highly therapy-refractory migraine patients: First German Real-world evidence
Authors: Scheffler Armin , Messel Olga , Wurthmann Sebastian , Nsaka Michael , Kleinschnitz Christoph , Glas Martin , Naegel Steffen , Holle-Lee Dagny
Published: May 2020

Background Calcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding efficacy and tolerability of erenumab in highly therapy-refractory patients are not available, yet, although many patients treated with CGRP mAB under real world conditions can be considered as highly therapy-refractory. Methods Clinical routine data of highly therapy-refractory migraine patients treated with erenumab 70mg for three months between November 2018 and December 2019 in the West German Headache Center, University Hospital Essen, Germany, were analysed. Monthly migraine days (MMD), monthly headache days (MHD) and days of acute medication intake (AMD) were assessed. Statistical analysis was performed using the Wilcoxon test. Descriptive statistics were performed to evaluate changes of vegetative symptoms, acute medication response, side effects, as well as treatment satisfaction. Results Complete clinical data were available for 26 episodic (EM) and 74 chronic (CM) migraineurs. Sixty-six % (n=49) of CM patients had an additional medication overuse headache (MOH). After three months 57.7% of EM patients and 41.9% of CM patients had a 50% or greater reduction of MMD. The mean number of MMD was reduced by 3.43 (SE 1.26) in EM, and by 4.72 (SE 0.87) in CM. Thirty-nine patients (52.7%) returned from chronic to episodic course of migraine. After three months, 23 patients (46.9%) were not suffering from a MOH anymore. Conclusions Erenumab seems to be a promising therapeutic option in highly therapy-refractory migraine patients.