bluuebunny/crossref_metadata_2025 huggingface dataset:
POSE-ID-on—A Novel Framework for Artwork Pose Clustering
Authors: Marsocci Valerio , Lastilla Lorenzo
Published: April 2021

In this work, we focus our attention on the similarity among works of art based on human poses and the actions they represent, moving from the concept of Pathosformel in Aby Warburg. This form of similarity is investigated by performing a pose clustering of the human poses, which are modeled as 2D skeletons and are defined as sets of 14 points connected by limbs. To build a dataset of properly annotated artwork images (that is, including the 2D skeletons of the human figures represented), we relied on one of the most popular, recent, and accurate deep learning frameworks for pose tracking of human figures, namely OpenPose. To measure the similarity between human poses, two alternative distance functions are proposed. Moreover, we developed a modified version of the K-Medians algorithm to cluster similar poses and to find a limited number of poses that are representative of the whole dataset. The proposed approach was also compared to two popular clustering strategies, that is, K-Means and the Nearest Point Algorithm, showing higher robustness to outliers. Finally, we assessed the validity of the proposed framework, which we named POSE-ID-on, in both a qualitative and in a quantitative way by simulating a supervised setting, since we lacked a proper reference for comparison.
Liquid and Solid Embolic Agents in Gonadal Veins
Authors: Tiralongo Francesco , Distefano Giulio , Palermo Monica , Granata Antonio , Giurazza Francesco , Vacirca Francesco , Palmucci Stefano , Venturini Massimo , Basile Antonio
Published: April 2021

Male varicocele and pelvic congestion syndrome (PCS) are common pathologies with high predominance in young patients, having a high impact on the quality of life and infertility. Lately, the use of different endovascular embolization techniques, with various embolizing agents, shows good technical results and clinical outcomes. With the aim of presenting the “state of the art” of endovascular techniques for the treatment of male varicocele and PCS, and to discuss the performance of the different embolic agents proposed, we conducted an extensive analysis of the relevant literature and we reported and discussed the results of original studies and previous meta-analyses, providing an updated guide on this topic to clinicians and interventional radiologists. We have also underlined the technical aspects for the benefit of those who approach this type of interventional treatment. Our review suggests promising results in both the endovascular embolic treatment of male varicocele and PCS; for varicocele, a success rate of between 70% and 100% and a recurrence rate of up to 16% is reported, while for PCS it has been found that technical success is achieved in almost all cases of endovascular treatment, with a highly variable recurrence rate based on reports. Complications are overall rather rare and are represented by periprocedural pain, migration of embolic media and vascular perforations: severe adverse events have been reported very rarely.
Dexamethasone in Patients Hospitalized with COVID-19: Whether, When and to Whom
Authors: Calzetta Luigino , Aiello Marina , Frizzelli Annalisa , Rogliani Paola , Chetta Alfredo
Published: April 2021

A clinical interpretation of the Randomized Evaluation of COVID-19 Therapy (RECOVERY) study was performed to provide a useful tool to understand whether, when, and to whom dexamethasone should be administered during hospitalization for COVID-19. A post hoc analysis of data published in the preliminary report of the RECOVERY study was performed to calculate the person-based number needed to treat (NNT) and number needed to harm (NNH) of 6 mg dexamethasone once daily for up to 10 days vs. usual care with respect to mortality. At day 28, the NNT of dexamethasone vs. usual care was 36.0 (95%CI 24.9–65.1, p < 0.05) in all patients, 8.3 (95%CI 6.0–13.1, p < 0.05) in patients receiving invasive mechanical ventilation, and 34.6 (95%CI 22.1–79.0, p < 0.05) in patients receiving oxygen only (with or without noninvasive ventilation). Dexamethasone increased mortality compared with usual care in patients not requiring oxygen supplementation, leading to a NNH value of 26.7 (95%CI 18.1–50.9, p < 0.05). NNT of dexamethasone vs. usual care was 17.3 (95%CI 14.9–20.6) in subjects <70 years, 27.0 (95%CI 18.5–49.8) in men, and 16.2 (95%CI 13.2–20.8) in patients in which the onset of symptoms was >7 days. Dexamethasone is effective in male subjects < 70 years that require invasive mechanical ventilation experiencing symptoms from >7 days and those patients receiving oxygen without invasive mechanical ventilation; it should be avoided in patients not requiring respiratory support.
Chronic Lung Allograft Dysfunction Post Lung Transplantation: A Review of Computed Tomography Quantitative Methods for Detection and Follow-Up
Authors: Hoang-Thi Trieu-Nghi , Chassagnon Guillaume , Hua-Huy Thong , Boussaud Veronique , Dinh-Xuan Anh-Tuan , Revel Marie-Pierre
Published: April 2021

Chronic lung allograft dysfunction (CLAD) remains the leading cause of morbidity and mortality after lung transplantation. The term encompasses both obstructive and restrictive phenotypes, as well as mixed and undefined phenotypes. Imaging, in addition to pulmonary function tests, plays a major role in identifying the CLAD phenotype and is essential for follow-up after lung transplantation. Quantitative imaging allows for the performing of reader-independent precise evaluation of CT examinations. In this review article, we will discuss the role of quantitative imaging methods for evaluating the airways and the lung parenchyma on computed tomography (CT) images, for an early identification of CLAD and for prognostic estimation. We will also discuss their limits and the need for novel approaches to predict, understand, and identify CLAD in its early stages.
Efficacy of Non-Invasive Radiofrequency-Based Diathermy in the Postoperative Phase of Knee Arthroplasty: A Double-Blind Randomized Clinical Trial
Authors: García-Marín Manuel , Rodríguez-Almagro Daniel , Castellote-Caballero Yolanda , Achalandabaso-Ochoa Alexander , Lomas-Vega Rafael , Ibáñez-Vera Alfonso Javier
Published: April 2021

Total knee replacement (TKR) surgery ameliorates knee function and the quality of life of patients, although 20% still experience dissatisfaction due to pain limiting their function. Radiofrequency Diathermy (MDR) has shown improvements in knee osteoarthritis and patellofemoral pain syndrome. As such, this study aims to assess the effects of MDR in the postoperative treatment of TKR patients. Forty-two participants were allocated to an experimental, placebo, or control group. For two weeks, subjects performed daily knee exercises and MDR, knee exercises and placebo MDR, or only knee exercises. Data from the Visual Analogue Scale (VAS), Timed Up-and-Go (TUG) test, Five Times Sit-to-Stand Test (FSST), Western Ontario and McMaster Universities Arthritis Index (WOMAC), physical component summary (PCS), and the mental component summary (MCS) of the SF-12 questionnaire were collected. Group-by-time interaction was significant, with favorable results in the MDR group for VAS (p = 0.009) and WOMAC (p = 0.021). No significant differences were found for TUG, FSST, PCS, or MCS (p > 0.05). In conclusion, the addition of MDR to therapeutic knee exercises obtained better results for knee pain than exercise alone in patients who had recently undergone TKR surgery.
Barriers and Enablers for Artificial Intelligence in Dental Diagnostics: A Qualitative Study
Authors: Müller Anne , Mertens Sarah Marie , Göstemeyer Gerd , Krois Joachim , Schwendicke Falk
Published: April 2021

The present study aimed to identify barriers and enablers for the implementation of artificial intelligence (AI) in dental, specifically radiographic, diagnostics. Semi-structured phone interviews with dentists and patients were conducted between the end of May and the end of June 2020 (convenience/snowball sampling). A questionnaire developed along the Theoretical Domains Framework (TDF) and the Capabilities, Opportunities and Motivations influencing Behaviors model (COM-B) was used to guide interviews. Mayring’s content analysis was employed to point out barriers and enablers. We identified 36 barriers, conflicting themes or enablers, covering nine of the fourteen domains of the TDF and all three determinants of behavior (COM). Both stakeholders emphasized chances and hopes for AI. A range of enablers for implementing AI in dental diagnostics were identified (e.g., the chance for higher diagnostic accuracy, a reduced workload, more comprehensive reporting and better patient–provider communication). Barriers related to reliance on AI and responsibility for medical decisions, as well as the explainability of AI and the related option to de-bug AI applications, emerged. Decision-makers and industry may want to consider these aspects to foster implementation of AI in dentistry.
Can Psychological Empowerment Prevent Emotional Disorders in Presence of Fear of COVID-19 in Health Workers? A Cross-Sectional Validation Study
Authors: Llorente-Alonso Marta , García-Ael Cristina , Topa Gabriela , Sanz-Muñoz María Luisa , Muñoz-Alcalde Irene , Cortés-Abejer Beatriz
Published: April 2021

The global emergency produced by COVID-19 has been a turning point for health organizations. Healthcare professionals have been exposed to high levels of stress and workload. Close contact with infected patients and the infectious capacity of COVID-19 mean that this group is especially vulnerable to contagion. In various countries, the Fear of COVID-19 Scale has been shown to be a fast and reliable tool. Early detection of fear complements clinical efforts to prevent emotional disorders. Thus, concepts focused on positive occupational health, such as Job Crafting or psychological empowerment (PE), have been examined as a tool to prevent mental health problems at work. In this work, we intended to adapt and validate the 7-item Fear of COVID-19 Scale in health workers (N = 194). The interpretation of the measurement model indicates adequate values of internal consistency reliability, and convergent and discriminant validity. The overall goodness of fit of the model was also adequate. The structural model indicates that the implementation of job crafting measures in health services leads to workers’ greater PE. High levels of anxiety and depression prevent health professionals from psychologically detaching from work. In turn, PE can reduce the emotional disorders caused by the fear of COVID-19.
Development and Validation of an Early Mortality Risk Score for Older Patients Treated with Chemotherapy for Cancer
Authors: Feliu Jaime , Pinto Alvaro , Basterretxea Laura , López-San Vicente Borja , Paredero Irene , Llabrés Elisenda , Jiménez-Munárriz Beatriz , Antonio-Rebollo Maite , Losada Beatriz , Espinosa Enrique , Gironés Regina , Custodio Ana Belén , Muñoz María del Mar , Díaz-Almirón Mariana , Gómez-Mediavilla Jenifer , Torregrosa María Dolores , Soler Gema , Cruz Patricia , Higuera Oliver , González-Montalvo Juan Ignacio , Molina-Garrido María José
Published: April 2021

Background: Estimation of life expectancy in older patients is relevant to select the best treatment strategy. We aimed to develop and validate a score to predict early mortality in older patients with cancer. Patients and Methods: A total of 749 patients over 70 years starting new chemotherapy regimens were prospectively included. A prechemotherapy assessment that included sociodemographic variables, tumor/treatment variables, and geriatric assessment variables was performed. Association between these factors and early death was examined using multivariable logistic regression. Score points were assigned to each risk factor. External validation was performed on an independent cohort. Results: In the training cohort, the independent predictors of 6-month mortality were metastatic stage (OR 4.8, 95% CI [2.4–9.6]), ECOG-PS 2 (OR 2.3, 95% CI [1.1–5.2]), ADL ≤ 5 (OR 1.7, 95% CI [1.1–3.5]), serum albumin levels ≤ 3.5 g/dL (OR 3.4, 95% CI [1.7–6.6]), BMI < 23 kg/m2 (OR 2.5, 95% CI [1.3–4.9]), and hemoglobin levels < 11 g/dL (OR 2.4, 95% CI (1.2–4.7)). With these results, we built a prognostic score. The area under the ROC curve was 0.78 (95% CI, 0.73 to 0.84), and in the validation set, it was 0.73 (95% CI: 0.67–0.79). Conclusions: This simple and highly accurate tool can help physicians making decisions in elderly patients with cancer who are planned to initiate chemotherapy treatment.
Pathophysiology, Diagnosis, and Treatment of Patients with Concomitant Severe Aortic Stenosis and Coronary Artery Disease: A Closer Look to the Unresolved Perplexity
Authors: Di Gioia Giuseppe , Bartunek Jozef , Tesorio Tullio , Vukcevic Vladan , Aleksandric Srdjan , Dobric Milan , Franco Danilo , Barbato Emanuele , Banovic Marko
Published: April 2021

Degenerative aortic stenosis (AS) and coronary artery disease (CAD) are the most prevalent cardiovascular diseases in developed countries, and they coexist in up to 50% of patients. The pathophysiological rationale behind concomitant AS and CAD is discussed in detail in this review, together with prognostic implications. Detecting CAD in patients with AS may be challenging, as AS may mask the existence and symptoms of CAD. The safety and reliability of invasive and non-invasive physiological assessment for epicardial coronary disease are also a matter of debate. Finally, the selection and timing of optimal treatment of CAD in patients with severe AS are still unclear. Given the aging of the population, the increase in the prevalence of AS, and the ongoing paradigm shift in its treatment, controversies in the diagnosis and treatment of CAD in the setting of AS are deemed to grow in importance. In this paper, we present contemporary issues in the diagnosis and management of CAD in patients with severe AS who are transcatheter aortic valve implantation (TAVI) candidates and provide perspective on the treatment approach.
Home Management of Heart Failure and Arrhythmias in Patients with Cardiac Devices during Pandemic
Authors: Matteucci Andrea , Bonanni Michela , Centioni Marco , Zanin Federico , Geuna Francesco , Massaro Gianluca , Sangiorgi Giuseppe
Published: April 2021

Background: The in-hospital management of patients with cardiac implantable electronic devices (CIEDs) changed early in the COVID-19 pandemic. Routine in-hospital controls of CIEDs were converted into remote home monitoring (HM). The aim of our study was to investigate the impact of the lockdown period on CIEDs patients and its influence on in-hospital admissions through the analysis of HM data. Methods: We analysed data recorded from 312 patients with HM during the national quarantine related to COVID-19 and then compared data from the same period of 2019. Results: We observed a reduction in the number of HM events in 2020 when compared to 2019. Non-sustained ventricular tachycardia episodes decreased (18.3% vs. 9.9% p = 0.002) as well as atrial fibrillation episodes (29.2% vs. 22.4% p = 0.019). In contrast, heart failure (HF) alarm activation was lower in 2019 than in 2020 (17% vs. 25.3% p = 0.012). Hospital admissions for critical events recorded with CIEDs dropped in 2020, including those for HF. Conclusions: HM, combined with telemedicine use, has ensured the surveillance of CIED patients. In 2020, arrhythmic events and hospital admissions decreased significantly compared to 2019. Moreover, in 2020, patients with HF arrived in hospital in a worse clinical condition compared to previous months.
Indications and Findings of Upper Endoscopies in Males and Females, Are They the Same or Different?
Authors: Abu-Freha Naim , Gat Roni , Philip Aerin , Yousef Baha , Ben Shoshan Liza , Yardeni David , Nevo-Shor Anat , Novack Victor , Etzion Ohad
Published: April 2021

Sex and gender can affect the prevalence and prognosis of diseases. Our aim was to assess similarities and differences for males and females who underwent an upper endoscopy, with regards to indications and results. We reviewed all upper endoscopy reports from 2012 to 2016. Data regarding demographics, indications, and procedure findings were collected. The upper endoscopy findings were compared regarding the most common indications: gastroesophageal reflux, abdominal pain, gastrointestinal bleeding, and anemia. We investigated 12,213 gastroscopies among males (age, 56.7 ± 17.4) and 15,817 among females (age, 56.0 ± 17.3, p = 0.002). Males who underwent an upper endoscopy for gastroesophageal reflux had higher rates of esophagitis (7.7% vs. 3.4%, p < 0.001) and Barret’s esophagus (4.4% vs. 1.5%, p < 0.001). Females who underwent an upper endoscopy for abdominal pain had a higher rate of hiatal hernia, whereas males had higher rates of esophagitis, helicobacter pylori infection, gastritis, gastric ulcer, duodenitis, and duodenal ulcer (p < 0.001). Gastrointestinal bleeding as an indication for upper endoscopy showed that helicobacter, duodenitis, and duodenal ulcers are more common among males compared to females (p < 0.001). Males with anemia who underwent an upper endoscopy had higher rates of esophagitis (p = 0.021) gastritis (p = 0.002), duodenitis (p < 0.001), and duodenal ulcer (p < 0.001). We found significant differences regarding the pathological gastroscopy findings between males and females in relation to the different indications.
Rapid Decline of Serum Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) in Non-Cirrhotic Patients with Chronic Hepatitis C Infection Receiving Direct-Acting Antiviral Therapy
Authors: Grimm Jonathan , Peschel Georg , Müller Martina , Schacherer Doris , Wiest Reiner , Weigand Kilian , Buechler Christa
Published: April 2021

Direct-acting antivirals (DAAs) efficiently eradicate the hepatitis C virus (HCV). Low-density lipoprotein (LDL) levels increase rapidly upon DAA treatment. Proprotein convertase subtilisin/kexin 9 (PCSK9) induces degradation of the hepatic LDL receptor and thereby elevates serum LDL. The aim of this study was to determine serum PCSK9 concentrations during and after DAA therapy to identify associations with LDL levels. Serum PCSK9 was increased in 82 chronic HCV-infected patients compared to 55 patients not infected with HCV. Serum PCSK9 was low in HCV patients with liver cirrhosis, but patients with HCV-induced liver cirrhosis still exhibited higher serum PCSK9 than patients with non-viral liver cirrhosis. Serum PCSK9 correlated with measures of liver injury and inflammation in cirrhotic HCV patients. In patients without liver cirrhosis, a positive association of serum PCSK9 with viral load existed. Serum PCSK9 was not different between viral genotypes. Serum PCSK9 did not correlate with LDL levels in HCV patients irrespective of cirrhotic status. Serum PCSK9 was reduced, and LDL was increased at four weeks after DAA therapy start in non-cirrhotic HCV patients. Serum PCSK9 and LDL did not change upon DAA treatment in the cirrhotic group. The rapid decline of PCSK9 after the start of DAA therapy in conjunction with raised LDL levels in non-cirrhotic HCV patients shows that these changes are not functionally related.
Clinical Determinants of Disease Progression in Amyotrophic Lateral Sclerosis—A Retrospective Cohort Study
Authors: Requardt Maria Viktoria , Görlich Dennis , Grehl Torsten , Boentert Matthias
Published: April 2021

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is ultimately fatal but characterized by substantial phenotypic heterogeneity, which is known to impact long-term course and survival. This study investigated clinical determinants of disease progression and outcome in a large cohort of patients with ALS. Methods: Retrospective analysis included comprehensive data from 625 patients who attended a tertiary ALS centre at least twice. Patients were stratified according to five distinct clinical phenotypes: classical ALS; bulbar ALS; ALS with frontotemporal dementia (ALS-FTD); upper motor neuron predominant (UMNP); and lower motor neuron predominant (LMNP). Results: This study confirmed higher age at symptom onset, shorter latency to diagnosis and more rapid decline in the revised ALS Functional Rating Scale sum score as predictors of poor prognosis. Hazard ratios for shorter survival were higher in patients with ALS-FTD versus classical ALS, and in patients with versus without chronic obstructive pulmonary disease (COPD). Mean survival was longest in the UMNP phenotype group. Conclusions: This study confirmed established predictors of shorter survival in ALS and showed that concomitant COPD in particular relates to poor outcome.
Usefulness of Fecal Calprotectin in the Management of Patients with Toxigenic Clostridioides difficile
Authors: Suarez-Carantoña Cecilia , Rodriguez-Torres Argeme , Viteri-Noel Adrian , Pintado Vicente , Garcia-Fernandez Sergio , Mora-Pimentel Daniel , Escudero-Sanchez Rosa , Martin-Jusdado Fuencisla , Moreno Santiago , Cobo Javier
Published: April 2021

The availability of highly sensitive molecular tests for the detection of Clostridioides difficile in feces leads to overtreatment of patients who are probably only colonized. In this prospective study, the usefulness of fecal calprotectin (fCP) is evaluated in a cohort of patients with detection of toxigenic C. difficile in feces. Patients were classified by an infectious diseases consultant blinded to fCP results into three groups—group I, presumed Clostridioides difficile infection (CDI); group II, doubtful but treated CDI; and group III, presumed C. difficile colonization or self-limited CDI not needing treatment. One hundred and thirty-four patients were included. The median fCP concentrations were 410 (138–815) μg/g in group I, 188 (57–524) μg/g in group II, and 51 (26–97) μg/g in group III (26 cases); p < 0.05 for all comparisons. In forty-five out of 134 cases (33.5%), the fCP concentrations were below 100 µg/g. In conclusion, fCP is low in most patients who do not need treatment against C. difficile, and should be investigated as a potentially useful test in the management of patients with detected toxigenic C. difficile.
Secular Trends in Ablation Therapy for Graves’ Disease: An Analysis of a 15-Year Experience at a Tertiary Hospital in South Korea
Authors: Kim Min Joo , Kim Ye An , Cho Sun Wook , Kim Su-jin , Lee Kyu Eun , Park Young Joo , Park Do Joon , Cho Bo Youn
Published: April 2021

Ablation therapy, such as radioactive iodine (RAI) therapy or thyroidectomy, is generally used as the second-line treatment for Graves’ disease (GD) in Asia. This study investigated changes in the clinical characteristics and outcomes of ablation therapies for GD over 15 years. Patients who underwent ablation therapy between 2001 and 2015 at a single tertiary hospital were included. Among the 10,991 GD patients treated over this 15-year period, 1357 (12.3%) underwent ablation therapy, and the most common reason was intractable GD. The proportion of patients who underwent any type of ablation therapy significantly decreased from 9.0% (2001–2005) to 7.7% (2011–2015). However, the proportion of patients who underwent surgery significantly increased from 1.1% (2001–2005) to 2.4% (2011–2015), and the proportion of patients who received ablation therapy due to suspected thyroid cancer increased from 5% to 13% over time. With a median follow-up duration of 6.2 years, remission was achieved in 86% and 98% of patients in the RAI and surgery groups, respectively, and these rates remained stable over time. In conclusion, although the proportion of patients who underwent ablation therapy for GD decreased during 15 years, the proportion of those who underwent surgery increased in association with the increased rate of suspected thyroid cancers.
Analysis of Personality Traits in Patients with Hodgkin Lymphoma
Authors: Roso-Bas Fatima , Alonso-Llobregat Maria Dolores , Bento Leyre , Sanchez-Gonzalez Blanca , Herraez Ines , Garcia-Dilla Pilar , Vallespir Catalina , Rado Francesca , Rodriguez Raquel , Garcia-Pallarols Francesc , Aguirre Irache , Bargay Joan , Sampol Antonia , Salar Antonio , Gutierrez Antonio
Published: April 2021

Hodgkin lymphoma (HL) is a highly-curable malignancy mostly affecting young people. As far as we know, there is no published study that has analyzed personality profiles in HL nor their potential role in lymphomagenesis, natural history, or response to treatment. We aim to explore the personality traits of HL patients, as well as the prevalence of mental disorders and suicide ideas. We retrospectively identified all alive HL patients from three centers (Son Espases and Son Llatzer University Hospitals and Hospital del Mar of Barcelona) for using NEO Five-Factor Inventory (NEO-FFI) and Personality Inventory for DSM-5 Brief Form. Patients with HL showed significantly higher neuroticism scores and lower conscientiousness, extraversion, and openness. Considering maladaptive personality traits, HL patients showed higher levels of detachment and psychoticism. All of these translated into the fact that HL patients showed more than double the prevalence of mental illnesses (41%) and more than triple the prevalence of suicidal ideation or attempts than the general population (15 and 6%, respectively). An exploratory analysis of biomarkers associated with HL personality traits showed that higher scores of neuroticism correlated with more elevated erythrocyte sedimentation rate (ESR) and red cell distribution width (RDW), suggesting a potential link between neuroticism and proinflammatory activity in HL.
The Clone Wars: Diagnosing and Treating Dysproteinemic Kidney Disease in the Modern Era
Authors: Avasare Rupali S. , Andeen Nicole K. , Havasi Andrea , Hogan Jonathan J.
Published: April 2021

Dysproteinemic kidney diseases are disorders that occur as the result of lymphoproliferative (B cell or plasma cell) disorders that cause kidney damage via production of nephrotoxic monoclonal immunoglobulins or their components. These monoclonal immunoglobulins have individual physiochemical characteristics that confer specific nephrotoxic properties. There has been increased recognition and revised characterization of these disorders in the last decade, and in some cases, there have been substantial advances in disease understanding and treatments, which has translated to improved patient outcomes. These disorders still present challenges to nephrologists and patients, since they are rare, and the field of hematology is rapidly changing with the introduction of novel testing and treatment strategies. In this review, we will discuss the clinical presentation, kidney biopsy features, hematologic characteristics and treatment of dysproteinemic kidney diseases.
Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis
Authors: Niepiekło-Miniewska Wanda , Matusiak Łukasz , Narbutt Joanna , Lesiak Alekandra , Kuna Piotr , Wiśniewski Andrzej , Kuśnierczyk Piotr
Published: April 2021

Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk. Here, we examined whether polymorphisms of other antigen-presenting machinery genes encoding immunoproteasome components LMP2 and LMP7 and peptide transporter components TAP1 and TAP2 may also affect susceptibility to AD or its outcome. We found that the LMP7 rs2071543*T allele decreased disease risk by about 1.5-fold (odds ratio 0.66, 95% confidence interval 0.44–0.99). On the other hand, the LMP2 rs1351383*C allele reduced the mean age at diagnosis from 23 to 15 years (p < 0.001). Similarly, the TAP1 rs1135216*C allele decreased the mean age at diagnosis from almost 20 to 14 years (p = 0.033). The results are discussed in light of other reports on the role of these polymorphisms in human disease.
Evaluation of the Impact of Different Pain Medication and Proton Pump Inhibitors on the Osteogenic Differentiation Potential of hMSCs Using 99mTc-HDP Labelling
Authors: Grossner Tobias , Haberkorn Uwe , Gotterbarm Tobias
Published: April 2021

First-line analgetic medication used in the field of musculoskeletal degenerative diseases, like Nonsteroidal anti-inflammatory drugs (NSAIDs), reduces pain and prostaglandin synthesis, whereby peptic ulcers are a severe adverse effect. Therefore, proton pump inhibitors (PPI) are frequently used as a concomitant medication to reduce this risk. However, the impact of NSAIDs or metamizole, in combination with PPIs, on bone metabolism is still unclear. Therefore, human mesenchymal stem cells (hMSCs) were cultured in monolayer cultures in 10 different groups for 21 days. New bone formation was induced as follows: Group 1 negative control group, group 2 osteogenic differentiation media (OSM), group 3 OSM with pantoprazole (PAN), group 4 OSM with ibuprofen (IBU), group 5 OSM with diclofenac (DIC), group 6 OSM with metamizole (MET), group 7 OSM with ibuprofen and pantoprazole (IBU + PAN), group 8 OSM with diclofenac and pantoprazole (DIC + PAN), group 9 OSM with metamizole and pantoprazole (MET + PAN) and group 10 OSM with diclofenac, metamizole and pantoprazole (DIC + MET + PAN). Hydroxyapatite content was evaluated using high-sensitive radioactive 99mTc-HDP labeling. Within this study, no evidence was found that the common analgetic medication, using NSAIDs alone or in combination with pantoprazole and/or metamizole, has any negative impact on the osteogenic differentiation of mesenchymal stem cells in vitro. To the contrary, the statistical results indicate that pantoprazole alone (group 3 (PAN) (p = 0.016)) or diclofenac alone (group 5 (DIC) (p = 0.008)) enhances the deposition of minerals by hMSCS in vitro. There is an ongoing discussion between clinicians in the field of orthopaedics and traumatology as to whether post-surgical (pain) medication has a negative impact on bone healing. This is the first hMSC in vitro study that investigates the effects of pain medication in combination with PPIs on bone metabolism. Our in vitro data indicates that the assumed negative impact on bone metabolism is subsidiary. These findings substantiate the thesis that, in clinical medicine, the patient can receive every pain medication needed, whether or not in combination with PPIs, without any negative effects for the osteo-regenerative potential.
Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?
Authors: Kałużna Małgorzata , Pawlaczyk Krzysztof , Schwermer Krzysztof , Hoppe Krzysztof , Yusuf Ibrahim Aisha , Czlapka-Matyasik Magdalena , Wrotkowska Elżbieta , Ziemnicka Katarzyna , Oko Andrzej , Ruchała Marek
Published: April 2021

Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropometric and biochemical parameters related to bone metabolism were studied in 73 patients on chronic hemodialysis (48 males, 25 females; mean age of 57 years; HD vintage of 69.7 months). Of these subjects, 36 patients had diabetes or impaired glucose tolerance (DM/IGT), and 37 patients had normal glucose tolerance (NGT). Dual-energy X-ray absorptiometry of the femoral neck and lumbar spine were also performed. Results: No differences were observed in preptin levels between DM/IGT and NGT HD patients. Preptin was positively correlated with HD vintage (r = 0.312, p = 0.007). Negative correlations between preptin and bone mineral density (BMD), T-score, and Z-score in the lumbar spine (L2-L4) were observed (r = −0.319, p = 0.009; r = −0.341, p = 0.005; r = −0.375, p = 0.002). Preptin was positively correlated with parathormone (PTH) levels (r = 0.379, p < 0.001) and osteocalcin levels (r = 0.262, p = 0.027). Conclusions: The results indicate that preptin may reflect on bone and mineral metabolism disturbances seen in HD patients. The significant correlation of preptin with PTH and osteocalcin suggests that preptin may be important in indirect measurement of bone turnover in HD patients.
Analytical Study of Porous Organosilicate Glass Films Prepared from Mixtures of 1,3,5- and 1,3-Alkoxysilylbenzenes
Authors: Rasadujjaman Md , Wang Xuesong , Wang Yanrong , Zhang Jing , Arkhincheev Valeriy E. , Baklanov Mikhail R.
Published: April 2021

Organosilicate glass (OSG)-based porous low dielectric constant (low-k) films with different molar ratios of 1,3,5-tris(triethoxysilyl)benzene to 1,3-bis(triethoxysilyl)benzene bridging organic groups (1:3 and 1:7) were spin-on deposited, followed by a soft bake in air and N2 at 150 °C and hard bake in air and N2 at 400 °C. Non-ionic template (Brij®30) concentrations were varied from 0 to 41 wt% to control the porosity of the films. The chemical composition of the matrix of the films was evaluated and discussed with the shrinkage of the film during the curing, refractive indices, mechanical properties, k-values, porosity and pore structure. The chemical composition of the film cured in both air and N2-containing ambient were evaluated and compared. The benzene bridging groups containing films change their porosity (0 to 43%) but keep the pore size constant and equal to 0.81 nm when porosity is lower than 30%. The k-value decreases with increasing porosity, as expected. The films containing benzene bridge have higher a Young’s modulus than plasma-enhanced chemical vapor deposition (PECVD) methyl-terminated low-k films with the same porosity and show good hydrophobic properties after a hard bake and close to the values reported for 1,4-benzene-bridged films. The fabricated films show good stability after a long time of storage. However, the improvement of mechanical properties was lower than the values predicted by the published literature data. It was concluded that the concentration of 1,3,5-benzene bridges was below the stiffness threshold required for significant improvement of the mechanical properties. The films show UV-induced luminescence with a photon energy of 3.6 to 4.3 eV. The luminescence is related to the presence of oxygen-deficient-type defects or their combination with organic residues. The most intensive luminescence is observed in as-deposited and soft bake samples, then the intensity is reduced after a hard bake. It is assumed that the oxygen-deficient centers form because of the presence of Si–OC2H5 groups in the films and the concentration of these centers reduces when all these groups completely transformed into siloxane (Si–O–Si).
Numerical Investigations on Thermal Forming Limit Testing with Local Inductive Heating for Hot Forming of AA7075
Authors: Reuther Franz , Lieber Thomas , Heidrich Jürgen , Kräusel Verena
Published: April 2021

Forming 7000-series aluminum alloys under elevated temperatures is particularly attractive due to their increased formability. To enable process design by finite element simulation for hot forming, strain-based criteria, such as temperature-dependent forming limit diagrams (TFLD), can be consulted to assess forming feasibility. This work numerically investigates the extent to which in-plane experimental concepts with partial inductive heating are suitable for detecting discrete failure points in TFLD. In particular, an alternative to the currently widely used thickness-reduced specimen geometries was created for cruciform specimens under biaxial tension. First, the temperature-dependent and strain-rate-dependent flow behavior was investigated for AA7075 under uniaxial tension. A heat source model for partial inductive heating was inversely parameterized based on heating experiments. Subsequently, the test procedures were simulated with different specimen geometries under discrete strain conditions. Different concepts were discussed for deriving a suitable specimen shape for the biaxial tension case, and the influence of different notch and slot forms were shown. The simulations showed that partial inductive heating was suitable to induce failure situations, thus creating TFLDs. For the biaxial tension case, a sufficiently large temperature gradient was required to use cruciform specimens without thickness reduction.
Characterizing Depth of Defects with Low Size/Depth Aspect Ratio and Low Thermal Reflection by Using Pulsed IR Thermography
Authors: Moskovchenko Alexey , Švantner Michal , Vavilov Vladimir , Chulkov Arsenii
Published: April 2021

This study is focused on the quantitative estimation of defect depth by applying pulsed thermal nondestructive testing. The majority of known defect characterization techniques are based on 1D heat conduction solutions, thus being inappropriate for evaluating defects with low aspect ratios. A novel method for estimating defect depth is proposed by taking into account the phenomenon of 3D heat diffusion, finite lateral size of defects and the thermal reflection coefficient at the boundary between a host material and defects. The method is based on the combination of a known analytical model and a non-linear fitting (NLF) procedure. The algorithm was verified both numerically and experimentally on 3D-printed polylactic acid plastic samples. The accuracy of depth prediction using the proposed method was compared with the reference characterization technique based on thermographic signal reconstruction to demonstrate the efficiency of the proposed NLF method.
Setting Time and Strength Monitoring of Alkali-Activated Cement Mixtures by Ultrasonic Testing
Authors: Tekle Biruk Hailu , Hertwig Ludwig , Holschemacher Klaus
Published: April 2021

Alkali-activated cement (AAC) is a promising binder that replaces ordinary Portland cement (OPC). In this study, the development of setting time and strength of AAC mixes were studied using ultrasonic testing method. The test results were compared with traditional Vicat setting time and compressive and flexural strengths. The findings showed that setting times and strengths have a strong correlation with ultrasonic velocity curve. The initial setting time corresponds well with the ultrasonic velocity curve’s dormant period, and the final setting time with the time it takes to reach the velocity curve’s maximum acceleration. Both setting times also showed a correlation with the value of the maximum acceleration. An exponential relation was found between the ultrasonic velocity and the compressive and flexural strengths. The effect of binder content, alkaline solid to binder ratio (AS/B), sodium silicate to sodium hydroxide solids ratio (SS/SH), and total water to total solid binder ratio (TW/TS) on the strength and setting time are also studied using Taguchi method of experimental design. AS/B ratio showed a significant influence on the setting time of AAC while TW/TS ratio showed only a minor effect. The ultrasonic velocities were able to capture the effect of the different parameters similar to the compressive strength. The velocity decreased mainly with the increase of TW/TS ratio and binder content, while AS/B and SS/SH ratios showed a lower influence.
A State-of-the-Art Review on Advanced Joining Processes for Metal-Composite and Metal-Polymer Hybrid Structures
Authors: Lambiase Francesco , Scipioni Silvia Ilaria , Lee Chan-Joo , Ko Dae-Cheol , Liu Fengchao
Published: April 2021

Multi-materials of metal-polymer and metal-composite hybrid structures (MMHSs) are highly demanded in several fields including land, air and sea transportation, infrastructure construction, and healthcare. The adoption of MMHSs in transportation industries represents a pivotal opportunity to reduce the product’s weight without compromising structural performance. This enables a dramatic reduction in fuel consumption for vehicles driven by internal combustion engines as well as an increase in fuel efficiency for electric vehicles. The main challenge for manufacturing MMHSs lies in the lack of robust joining solutions. Conventional joining processes, e.g., mechanical fastening and adhesive bonding involve several issues. Several emerging technologies have been developed for MMHSs’ manufacturing. Different from recently published review articles where the focus is only on specific categories of joining processes, this review is aimed at providing a broader and systematic view of the emerging opportunities for hybrid thin-walled structure manufacturing. The present review paper discusses the main limitations of conventional joining processes and describes the joining mechanisms, the main differences, advantages, and limitations of new joining processes. Three reference clusters were identified: fast mechanical joining processes, thermomechanical interlocking processes, and thermomechanical joining processes. This new classification is aimed at providing a compass to better orient within the broad horizon of new joining processes for MMHSs with an outlook for future trends.
Potentiometric Sensor with High Capacity Composite Composed of Ruthenium Dioxide and Poly(3,4-ethylenedioxythiophene) Polystyrene Sulfonate
Authors: Lenar Nikola , Piech Robert , Paczosa-Bator Beata
Published: April 2021

This work presents the first-time application of the ruthenium dioxide–poly(3,4-ethylenedioxythiophene) polystyrene sulfonate high-capacity composite material as a mediation layer in potassium selective electrodes, which turned out to significantly enhance the electrical and analytical parameters of the electrodes. The idea was to combine the properties of two different types of materials: a conducting polymer, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate, and a metal oxide, ruthenium dioxide, in order to obtain the material for a solid-contact layer of great electrical and physicochemical parameters. The preparation method for composite material proposed in this work is fast and easy. The mediation layer material was examined using a scanning electron microscope and chronopotentiometry in order to confirm that all requirements for mediation layers materials were fulfilled. Ruthenium dioxide–poly(3,4-ethylenedioxythiophene) polystyrene sulfonate nancomposite material turned out to exhibit remarkably high electrical capacitance (of approximately 17.5 mF), which ensured great performance of designed K+-selective sensors. Electrodes of electrical capacity equal to 7.2 mF turned out to exhibit fast and stable (with only 0.077 mV potential change per hour) potentiometric responses in the wide range of potassium ion concentrations (10−6 M to 10−1 M). The electrical capacity of ruthenium dioxide–poly(3,4-ethylenedioxythiophene) polystyrene sulfonate-contacted electrodes characterized by electrical capacitance parameters was the highest reported so far for this type of sensor.
Electroless Platinum Deposition Using Co3+/Co2+ Redox Couple as a Reducing Agent
Authors: Tamasauskaite-Tamasiunaite Loreta , Dordi Yezdi , Norkus Eugenijus , Stankeviciene Ina , Jagminiene Aldona , Naujokaitis Arnas , Tumonis Liudas , Buzas Vytenis , Maciulis Laurynas
Published: April 2021

In the present work, the kinetics of electroless deposition of Pt, using a cobalt ion redox system (Co3+/Co2+) as a reducing agent, has been investigated. The deposition rate of Pt depends on the pH, concentration of reactants, and temperature. The deaeration and bubbling of the plating solution with argon play an essential role. It was found that 0.11 mg cm−2 of Pt films could be deposited on the surface of a roughed glass sheet in one hour without replenishing the solution. Additional data have been obtained on the grounds of electrochemical quartz crystal microbalance experiments. The bubbling (agitation) of the electroless Pt plating solution with argon during the deposition of Pt results in a higher deposition rate and is ca. 3 µg cm−2 min−1. The Pt deposition rate is far less, and is as low as 0.14 µg cm−2 min−1 when the electroless Pt plating solution is not bubbled with argon during the deposition of Pt.
Material Selection and Characterization for a Novel Frame-Integrated Curtain Wall
Authors: Gargallo Mercedes , Cordero Belarmino , Garcia-Santos Alfonso
Published: April 2021

Curtain walls are the façade of choice in high-rise buildings and an indispensable element of architecture for a contemporary city. In conventional curtain walls, the glass panels are simply supported by the metal framing which transfers any imposed load to the building structure. The absence of composite action between glass and metal results in deep frames, protruding to the inside, occupying valuable space and causing visual disruption. In response to the limited performance of conventional systems, an innovative frame-integrated unitized curtain wall is proposed to reduce structural depth to one fifth (80%) allowing an inside flush finish and gaining nettable space. The novel curtain wall is achieved by bonding a pultruded glass fiber reinforced polymer (GFRP) frame to the glass producing a composite insulated glass unit (IGU). This paper selects the candidate frame and adhesive materials performing mechanical tests on GFRP pultrusions to characterize strength and elasticity and on GFRP-glass connections to identify failure module and strength. The material test results are used in a computer-based numerical model of a GFRP-glass composite unitized panel to predict the structural performance when subjected to realistic wind loads. The results confirm the reduction to one fifth is possible since the allowable deflections are within limits. It also indicates that the GFRP areas adjacent to the support might require reinforcing to reduce shear stresses.
Effect of Silicon Nitride and Graphene Nanoplatelets on the Properties of Aluminum Metal Matrix Composites
Authors: Abdelatty Rokaya , Khan Adnan , Yusuf Moinuddin , Alashraf Abdullah , Shakoor Rana Abdul
Published: April 2021

This research work aims at investigating the influence of a fixed content of silicon nitride (Si3N4) and varied contents of graphene nanoplatelets (GNPs) on the physical (density, structural, morphological) and mechanical properties (microhardness, nanoindentation) of Al-Si3N4-GNPs composites. The composites were fabricated by a microwave-assisted powder metallurgy route. The Si3N4 concentration was fixed at (5 wt.%) in Al-Si3N4-GNPs composites while the GNPs concentration was varied between (0 wt.%) to (1.5 wt.%) with an increment of (0.5 wt.%). The structural analysis indicates the formation of phase pure materials with high crystallinity. The microstructural analysis confirmed the presence of the Si3N4 and GNPs showing enhanced agglomeration with the increasing amount of GNPs. Moreover, the surface roughness of the synthesized composites increases with an increasing amount of GNPs reaching its maximum value (RMS = 65.32 nm) at 1.5 wt.% of GNPs. The Al-Si3N4-GNPs composites exhibit improved microhardness and promising load-indentation behavior during nanoindentation when compared to pure aluminum (Al). Moreover, Al-Si3N4-GNPs composites demonstrate higher values of compressive yield strength (CYS) and ultimate compressive strength (UCS) when compared to pure Al despite showing a declining trend with an increasing amount of GNPs in the matrix. Finally, a shear mode of fracture is prevalent in Al-Si3N4-GNPs composites under compression loading.