bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel drug-drug interactions prediction method based on a graph attention network
Authors: Tan Xian , Fan Shijie , Duan Kaiwen , Xu Mengyue , Zhang Jingbo , Sun Pingping , Ma Zhiqiang
Published: August 2023

With the increasing need for public health and drug development, combination therapy has become widely used in clinical settings. However, the risk of unanticipated adverse effects and unknown toxicity caused by drug-drug interactions (DDIs) is a serious public health issue for polypharmacy safety. Traditional experimental methods for detecting DDIs are expensive and time-consuming. Therefore, many computational methods have been developed in recent years to predict DDIs with the growing availability of data and advancements in artificial intelligence. In silico methods have proven to be effective in predicting DDIs, but detecting potential interactions, especially for newly discovered drugs without an existing DDI network, remains a challenge. In this study, we propose a predicting method of DDIs named HAG-DDI based on graph attention networks. We consider the differences in mechanisms between DDIs and add learning of semantic-level attention, which can focus on advanced representations of DDIs. By treating interactions as nodes and the presence of the same drug as edges, and constructing small subnetworks during training, we effectively mitigate potential bias issues arising from limited data availability. Our experimental results show that our method achieves an F1-score of 0.952, proving that our model is a viable alternative for DDIs prediction. The codes are available at: https://github.com/xtnenu/DDIFramework.
Piecewise mABC fractional derivative with an application
Authors: Khan Hasib , Alzabut Jehad , Gómez-Aguilar J.F. , Agarwal Praveen
Published: August 2023

In this study, we give the notion of a piecewise modified Atangana-Baleanu-Caputo (mABC) fractional derivative and apply it to a tuberculosis model. This novel operator is a combination of classical derivative and the recently developed modified Atangana-Baleanu operator in the Caputo's sense. For this combination, we have considered the splitting of an interval $ [0, t_2] $ for $ t_2\in\mathbb{R}^+ $, such that, the classical derivative is applied in the first portion $ [0, t_1] $ while the second differential operator is applied in the interval $ [t_1, t_2] $. As a result, we obtained the piecewise mABC operator. Its corresponding integral is also given accordingly. This new operator is then applied to a tuberculosis model for the study of crossover behavior. The existence and stability of solutions are investigated for the nonlinear piecewise modified ABC tuberculosis model. A numerical scheme for the simulations is presented with the help of Lagrange's interpolation polynomial is then applied to the available data.
The mass formula for self-orthogonal and self-dual codes over a non-unitary commutative ring
Authors: Alahmadi Adel , Alshuhail Altaf , Solé Patrick
Published: August 2023

In this paper, we establish a mass formula for self-orthogonal codes, quasi self-dual codes, and self-dual codes over commutative non-unital rings $ {{\mathit {I}_p}} = \left < a, b | pa = pb = 0, a^2 = b, ab = 0 \right > $, where $ p $ is an odd prime. We also give a classification of the three said classes of codes over $ {{\mathit {I}_p}} $ where $ p = 3, 5, $ and $ 7 $, with lengths up to $ 3 $.
Physical phenomena of spectral relationships via quadratic third kind mixed integral equation with discontinuous kernel
Authors: Alhazmi Sharifah E. , Abdou M. A. , Basseem M.
Published: August 2023

Spectral relationships explain many physical phenomena, especially in quantum physics and astrophysics. Therefore, in this paper, we first attempt to derive spectral relationships in position and time for an integral operator with a singular kernel. Second, using these relations to solve a mixed integral equation (MIE) of the second kind in the space $ {L}_{2}\left[-\mathrm{1, 1}\right]\times C\left[0, T\right], T < 1. $ The way to do this is to derive a general principal theorem of the spectral relations from the term of the Volterra-Fredholm integral equation (V-FIE), with the help of the Chebyshev polynomials (CPs), and then use the results in the general MIE to discuss its solution. More than that, some special and important cases will be devised that help explain many phenomena in the basic sciences in general. Here, the FI term is considered in position, in $ {L}_{2}\left[-\mathrm{1, 1}\right], $ and its kernel takes a logarithmic form multiplied by a general continuous function. While the VI term in time, in $ C\left[0, T\right], T < 1, $ and its kernels are smooth functions. Many numerical results are considered, and the estimated error is also established using Maple 2022.
Depletion of dopamine in Parkinson's disease and relevant therapeutic options: A review of the literature
Authors: Ramesh Sairam , Arachchige Arosh S. Perera Molligoda
Published: August 2023

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects motor and cognition functions. The etiology of Parkinson's disease remains largely unknown, but genetic and environmental factors are believed to play a role. The neurotransmitter dopamine is implicated in regulating movement, motivation, memory, and other physiological processes. In individuals with Parkinson's disease, the loss of dopaminergic neurons leads to a reduction in dopamine levels, which causes motor impairment and may also contribute to the cognitive deficits observed in some patients. Therefore, it is important to understand the pathophysiology that leads to the loss of dopaminergic neurons, along with reliable biomarkers that may help distinguish PD from other conditions, monitor its progression, or indicate a positive response to a therapeutic intervention. Important advances in the treatment, etiology, and pathogenesis of Parkinson's disease have been made in the past 50 years. Therefore, this review tries to explain the different possible mechanisms behind the depletion of dopamine in PD patients such as alpha-synuclein abnormalities, mitochondrial dysfunction, and 3,4-dihydroxyphenylacetaldehyde (DOPAL) toxicity, along with the current therapies we have and the ones that are in development. The clinical aspect of Parkinson's disease such as the manifestation of both motor and non-motor symptoms, and the differential diagnosis with similar neurodegenerative disease are also discussed.
Information Systems Maintenance
Authors: Pilz Michael , Ebner Martin , Wachtler Josef
Published: August 2023

This work deals with the maintenance of information systems—specifically, with the maintenance of information systems that have a focus on teaching and learning. Depending on the context of an information system, there are different influencing factors for the maintenance of these systems. This work clarifies how the maintenance activities and their influencing factors differ in an information system for teaching and learning from other information systems, or why some influencing factors are particularly more important. The first step is to understand what maintenance means, why there is a need for maintenance, and which maintenance strategies can be used. Finally, the defined factors of influencing the maintenance of information systems for teaching and learning are evaluated during interviews with experts in order to be able to determine their relevance. A further part of this document is the influence of the General Data Protection Regulation (GDPR) guidelines on information systems maintenance, which came into force on May 25, 2018. These guidelines of the GDPR affect a large part of all information systems that process data—in particular, the processing of personal data. The GDPR regulates, among other things, the rights and obligations of data processing.
Effects of Inquiry-Based Teaching on Learning Efficiency in an Augmented Reality Environment
Authors: Sun Fengxuan
Published: August 2023

Virtual reality (VR) creates a realistic learning environment to immerse users, meet scenario requirements and natural interaction of learning media, and offer learners a highly immersible virtual-real mixed environment. To analyze the effects of inquiry-based teaching on learning efficiency of learners in an augmented reality (AR) environment, a questionnaire survey was given to 278 undergraduates in 4 grades from 6 universities in Wuhan. Contextual learning theory and flow theory were used as the theoretical basis to analyze the effects of the four aspects of inquiry-based teaching on learning efficiency of learners in AR environments. Differences in learning efficiency caused by different degrees of familiarity of learners with AR equipment were measured using analysis of variance (ANOVA). Results show that Cronbach’s α of the questionnaire, which was developed based on existing research questionnaires, is 0.909 and the KMO value is 0.869, indicating that the questionnaire has very good reliability and validity. Posing problems, collecting evidence, and proposing explanations for an inquiry-based teaching mode have significant influences on learning efficiency of learners: under 5%, 1%, and 1% levels, respectively. The degree of familiarity of learners with AR equipment has significant influence on learning efficiency at the 0.01% level. Results herein provide important guidance for promoting the fusion of AR and teaching activities, enriching the application of scientific teaching with AR technology in universities, and designing and developing ways to use AR teaching resources in different disciplines.
Apresentação
Authors: Bueno Luzia , Leurquin Eulália Vera Lúcia Fraga , Guimarães Ana Maria de Mattos , Bulea Bronckart Ecaterina
Published: August 2023

Apresentação do número especial em homenagem ao Prof. Dr. Joaquim Dolz (UNIGE).
Modelo teórico do gênero: etapa inicial da modelização didática
Authors: Barros Eliana Merlin Deganutti , Vieira Gonçalves Adair
Published: August 2023

Os objetivos deste artigo são apresentar o conceito de modelo teórico do gênero como uma das etapas da modelização didática sistematizada por pesquisadores de Genebra filiados ao Interacionismo Sociodiscursivo (ISD) e expor uma síntese do modelo teórico do gênero ‘crítica de cinema’. As etapas da modelização incluem: uma pesquisa bibliográfica para explorar alguns aspectos do contexto mais amplo de produção do gênero; a seleção de um corpus textual; uma descrição do gênero com base na análise do corpus, tendo como parâmetro os níveis organizacional e enunciativo que sistematizam o quadro de análise textual do ISD. A modelização teórica exposta revela a complexidade discursiva da crítica de cinema e fornece uma base para a elaboração de diferentes modelos didáticos do gênero.
Palavras-chave: gênero textual; modelo teórico; crítica de cinema.
A atorialidade: conceito e repercussão na docência
Authors: Preussler de Almeida Alessandra
Published: August 2023

Este artigo se insere nas discussões sobre o trabalho do professor e propõe a análise da atorialidade como um fator constituinte da profissionalidade docente. Para isso, retomamos aspectos pertinentes para a compreensão do seu conceito, o qual comporta características próprias do ator no nível da representação do papel do actante, ou seja, o indivíduo fonte do agir. Para fundamentar esta abordagem, utilizamos o escopo teórico-metodológico do Interacionismo Sociodiscursivo - ISD (Bronckart, 1999, 2006, 2008, 2013; Bulea, 2010, 2016; Almeida, 2015), trazendo as contribuições da Didática das Línguas, mais especificamente, os gestos didáticos (Aeby-Daghé; Dolz, 2008; Schneuwly, 2009). Os dados são oriundos de uma entrevista semiestruturada realizada com uma professora após sua participação em um dos módulos do curso de formação continuada, que tinha como proposta a realização de um Projeto Didático de Gênero com sua turma de alunos. Para a análise, aproximamos as “lentes” para identificar as figuras de ação. Os resultados revelam a verbalização dos elementos constitutivos da atorialidade docente que são as capacidades, os motivos e as intenções, com destaque para a relevância dos gestos didáticos no plano da intencionalidade.
Palavras-chave: Interacionismo Sociodiscursivo; atorialidade; dimensões do agir.
Gênero orais da esfera científica na Base Nacional Comum Curricular
Authors: Storto Letícia Jovelina , Costa-Maciel Débora Amorim Gomes da , Magalhães Tania Guedes
Published: August 2023

Neste artigo, analisamos a presença dos gêneros orais da esfera científica na Base Nacional Comum Curricular (BNCC) destinada ao Ensino Fundamental (1º ao 9º ano). Frente ao objeto em tela, refletimos sobre a concepção de oralidade que subjaz o documento; e buscamos identificar os gêneros orais de tal esfera indicados na BNCC para o campo científico. As inquietações direcionam nosso olhar para a análise documental e qualitativa no tratamento dos dados. Com vistas ao diálogo teórico, assumimos a oralidade como prática social manifestada numa diversidade de gêneros fundados na realidade sonora, bem como no tratamento didático do oral a partir de uma pedagogia específica. Os resultados sinalizam para dois cenários: i) apesar de a concepção de oralidade do documento reconhecer a supremacia da escrita, alguns desdobramentos não condizem com tal compreensão; ii) há presença de gêneros orais na esfera selecionada ao longo da Educação Básica, mas com distribuição desigual entre os anos iniciais (1º ao 5º) e anos finais (6º ao 9º). O cenário exige um maior investimento por parte dos sujeitos que usam a BNCC como documento normativo, no sentido de incorporar novos gêneros, sobretudo nos anos iniciais, e favorecer a ampliação das capacidades de linguagem nos aprendizes.   
Palavras-chave: Gêneros orais; Esfera Científica; Base Nacional Comum Curricular.
Transexualidade, transgênero e disforia de gênero nas páginas do Estadão: uma perspectiva diacrônica
Authors: Fukui Ana , Mendonça Berenice Bilharinho de , Lousada Lia Mesquista
Published: August 2023

Este artigo estuda as notícias publicadas no jornal Estado de São Paulo entre 1969 e 2015 sobre transexualidade. Os objetivos consistem em verificar os temas das matérias e identificar as vozes presentes, além de realizar uma caracterização do jornal de acordo com o pressuposto de situação de comunicação da Linguística. Os resultados obtidos indicam um aumento no número de matérias publicadas ao longo do tempo, bem como a ampliação dos assuntos abordados. Enquanto, nos primeiros 20 anos, somente médicos e juristas falam sobre o tema, a partir de 1990, as pessoas transexuais passam a ser ouvidas pelos jornalistas.
Palavras-chave: Transexualidade; Jornal; Notícias.
Epidemiology of acute poisoning among children in urban Sri Lanka: the experience of two tertiary care hospitals in Colombo district
Authors: Dayasiri Kavinda , Thadchanamoorthy V. , Jansz Michael , Dassanayake Senuri , Anand Geetha
Published: August 2023

Acute poisoning in children is an important public health problem and one of the leading causes of emergency department admissions following childhood injuries. Although most paediatric ingestions are accidental, children are at a higher risk for serious complications following ingestion of a similar toxic dose compared to adults. The current study evaluated the recent patterns and trends in acute poisoning among children in two tertiary care centers in urban Sri Lanka: Lady Ridge Hospital for Children, Colombo and North Colombo Teaching Hospital, Ragama. Out of 200 cases, the majority were between 1-5 years and male children outnumbered female children. The most common poisons included kerosene oil, paracetamol and “Good Luck” plants. Complication rate was low, and no mortalities were reported. Deliberate poisoning accounted for 1% of total poisonings. The current trends in poisoning among children living in urban Sri Lanka showed decreasing incidence of pesticide poisonings and increasing incidence of pharmaceutical poisonings and poisoning with ornamental plants.
Participation in extracurricular activities and associated factors among Jaffna medical students
Authors: Mathuvanthi T. , Keerthiga U. , Majure K. , Mahinthan C. , Priyamantha H. , Kumar R. , Sathiadas G.
Published: August 2023

Extracurricular activities (ECA) help to nurture the core competencies of a doctor. This study assessed participation in ECA, barriers and attitudes towards participation, and associated sociodemographic and academic factors among medical students of the University of Jaffna.This descriptive cross-sectional study was carried out at the Jaffna Medical Faculty. Stratified random sampling was used ensuring proportionate representation from each batch. Data were collected with a self-administered questionnaire. Frequencies, proportions, and the Chi squared test were used in the analysis with SPSS (v21).In total, 332 students participated (response rate 96.5%); 65.1% reported participating in ECA. Among them 44.9% participated in sports, while 47.2% were involved in cultural/ faith-based activities. The majority participated in ECA on less than 3 days per week (68.1%), and for less than 2 hours per day (61%). Lack of time (27.5%) and transport (24.6%) were key barriers to participation. Many agreed that ECA enabled new friendships (63.2%) and enhanced social skills (60.2%). Ethnicity (p=0.03) and household income (p=0.045) were significantly associated with the level of participation; Sinhala and Muslim students and those with lower income participated at a lower level. Although female students reported lower participation, there was no evidence of an association between gender and ECA participation (p>0.05). Programme phase (p<0.001) and first examination results (p=0.019) were significantly associated with level of participation; students in the para-clinical phase and those who achieved class honours reported a lower level of participation.Over a third of students do not participate in any type of ECA at the Jaffna Medical Faculty. Targeted interventions are needed to improve participation with consideration to the barriers and groups who are less likely to participate in ECA.
Primary antiphospholipid syndrome with adrenal insufficiency
Authors: Seyon S. , Peranantharajah T. , Nalayini J. , Rushanthini S. , Pirannavan R.
Published: August 2023

Antiphospholipid syndrome (APS) is a thrombophilic condition leading to multiple complications. Primary APS rarely causes primary adrenal insufficiency, but it can be life-threatening. In the present report, a patient presents with symptoms and signs of adrenal insufficiency and subsequent hormone level tests and radiological findings led to a diagnosis of primary APS with adrenal insufficiency.
Right adrenal mematoma causing partial small bowel obstruction in a term neonate
Authors: Sanseevan H. , Manivannan S. , Thagshanaa C. , Gayathri S. , Dayasiri M. B. K. C. , Srisaravanapavathan N. , Nawarathne M. V. D.
Published: August 2023

Adrenal haematoma in the neonate commonly occurs during the first week of life and usually proceeded by either mechanical trauma or metabolic stresses including hypoxia, hypovolaemia, septicaemia and coagulopathy. Haematomas commonly present with abdominal mass, anemia and hypovolaemia. The authors report a large for gestational age male newborn who presented with partial small bowel obstruction following adrenal haematoma in a background of an otherwise uneventful vaginal delivery. Although this presentation is extremely rare, it is important to timely investigate all sick newborns with presentations which mimic acute surgical abdomen. Accurate diagnosis enables both avoidance of unnecessary surgical explorations and optimal conservative management.
Adjuvant antihypertensive effect of a novel Ayurvedic herbal formulation in fructose-induced albino rat model
Authors: Pratibha  , Rath Sudipta Kumar , Sharma Gaurav
Published: August 2023

BACKGROUND:

Hypertension is the most common treatable risk factor for cardiovascular disease. Hypertension is a multifactorial clinical condition and thus can be managed in multiple pathways. Management of hypertension with modern antihypertensive medication is not ideally effective due to side effects and adverse effects associated with their long-term use. Thus, a novel Ayurvedic formulation NIA/DG/2015/01 test drug (TD) was designed to address multiple pathway management of hypertension. Further, albeit the simultaneous use of modern and Ayurveda antihypertensive is common, there is no systematic study to evaluate the combined effect and adverse effect of this simultaneous use. This study is aimed to evaluate the antihypertensive activity of a novel Ayurvedic formulation (TD) both as an adjuvant with modern antihypertensive drugs and as a stand-alone drug in fructose-induced hypertensive albino rats.

METHODS:

TD comprises of the combination of aqueous extract of root of Boerhavia diffusa L., whole plant of Convolvulus prostratus Forssk., rhizome of Nardostachys jatamansi (D. Don) DC., bark of Terminalia arjuna (Roxb. ex DC.) Wight & Arn., and root of Withania somnifera (L.) Dunal. TD was administered 90 mg/kg body weight, P.O. twice a day for 28 days to evaluate its effect in fructose-induced hypertensive rats using the Quinapril as a standard drug. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured on day 7th, 14th, 21st, and 28th day of drug administration by noninvasive BP system for rodents.

RESULTS:

TD significantly reduced SBP and DBP in comparison to the standard drug Quinapril. (P < 0.001, one-way analysis of variance followed by Turkey’s multiple comparison test and Dunnett’s multiple comparison test).

CONCLUSION:

Ayurvedic formulation possesses significant antihypertensive activity in fructose-induced hypertensive albino rat model.
Safety assessment of Libirite capsule (a polyherbal formulation) in experimental animals (Sprague Dawley rats and Swiss albino mice)
Authors: Narke Vasant E. , Nipanikar Sanjay U. , Khisti Ujwala V. , Upasani Sachin A.
Published: August 2023

BACKGROUND:

Libirite capsule (LC) is a polyherbal formulation, developed to treat erectile dysfunction and loss of libido. Present study aimed to perform the acute oral toxicity studies of LC in Swiss Albino mice and Sprague Dawley rats, and repeated dose subchronic 90-day toxicity study were performed to assess the safety of LC.

METHODS:

LC was orally administered at 2000 mg/kg to the animals as per Organization for Economic Cooperation and Development (OECD)-423 guidelines. In a repeated dose oral toxicity study, LC was administered through oral gavage in a dose of 250, 500, and 1000 mg/kg for 90 days and compared with control groups as per OECD-408 guidelines. Posttreatment changes in food consumption, body weight, and biochemical, hematological, and laboratory parameters were observed.

RESULTS:

LC did not produce any adverse or mortality events in animals during acute studies. In a 90-day toxicity study, rats exhibited no toxicity symptoms or death. No significant changes were found in hematological and biochemical parameters. No significant alteration was seen in organ and body weight. Microscopic findings were incidental and identical for control and treated animals at 1000 mg/kg. LC did not produce any histopathological changes in target organs. No change in the recovery group was observed when compared with the control group animals, which indicated a complete reversal.

CONCLUSIONS:

Median lethal dose50 of LC was observed to be more than 2000 mg/kg. No observed adverse effect level of LC was considered 1000 mg/kg.
Classical Ayurveda herb Gojihva and its one of the source plants Launaea nudicaulis (L.) Hook. f.: A comprehensive review
Authors: Kumar Vishal , Bidhuri Yashika , Ghildiyal Shivani , Aggarwal Punam , Tripathi Ashish Kumar , Nesari Tanuja Manoj
Published: August 2023

The herb Gojihva is enumerated in Ayurveda as a Shaaka (vegetable) and is also a medicine in the management of various diseases. The official source of Gojihva is as per Ayurvedic Pharmacopeia of India is Onosma bracteatum Wall. However, at present many botanical sources, Caccinia glauca Savi., Trichodesma indicum R.Br., Elephantopus scaber L., Launaea species., and Launaea nudicaulis (L.) Hook. f. (L. N) are also considered as botanical sources of Gojihva by many scholars. Gojihva is mentioned in major Ayurveda classics but a comprehensive data regarding its synonyms, properties, and uses are not framed in a systematic manner. Further, there are no published contemporary reviews for its one of the source plants Launaea nudicaulis L. (Hook.) f. Thus, a comprehensive review of Gojihva is done from various Ayurveda classics. The relevant information about L.N is collected from research articles published in various journals, floras, and books. The review revealed that various synonyms (Darvipatri, Godhumika, Kharpatri) indicating morphology of plant are given to Gojihva in Nighantus. The pharmacodynamics attributes are Tikta rasa (bitter taste), Laghu guna (light), Sheeta veerya (cold potency), Katu vipaka (pungent biotransformation), and Kaphapittaghna (pacifies Kapha and Pittadosha). It is indicated for external and internal administration for various diseases such as Raktapitta (bleeding disorder), Kushta (skin diseases), Prameha (diabetes mellitus), and Vrana (wound). L.N is reported for anti-diabetic, antioxidant, and anti-microbial potential. The review suggests that L.N is not evaluated on scientific parameters for most of the classical Ayurveda indications. Therefore, the present article may provide the scope for the rational evaluation of L.N on various classical Ayurveda indications.
Comparison of the efficacy of ultrasound guided pectoralis-II block and intercostal approach to paravertebral block (proximal intercostal block) among patients undergoing conservative breast surgery: A randomised control study
Authors: Ameta Nihar , Ramkiran Seshadri , Vivekanand Desiraju , Honwad Manish , Jaiswal Alok , Gupta Manoj Kumar
Published: August 2023

Background and Aims:

Regional anesthesia techniques have attributed a multimodal dimension to pain management after breast surgery. The intercostal approach to paravertebral block has been gaining interest, becoming an alternative to conventional paravertebral block, devoid of complexities in its approach, being recognized as the proximal intercostal block. Parallel to the widespread acceptance of fascial plane blocks in breast surgery, pectoralis II block has emerged as being non-inferior to paravertebral block. The aim of this study was to evaluate the efficacy of two independent fascial plane blocks, proximal intercostal block and pectoralis II block, in breast conservation surgery.

Material and Methods:

This prospective, randomized control, pilot study included 40 patients, randomly allocated among two groups: proximal intercostal block and pectoralis II block.

Results:

The pectoralis II block group had significantly lower pain scores at rest in the immediate postoperative period but became comparable with the proximal intercostal block group in the late postoperative period. Pain scores on movement though were lower at 0 h postoperatively and became comparable with the proximal intercostal block group subsequently. Although the pectoralis II group had earlier recovery in the post-anesthesia care unit, the overall time to discharge from the hospital was comparable and not influential. Both groups had high patient satisfaction scores and similar perioperative opioid consumption. Sedation, time to first rescue analgesia, and postoperative nausea vomiting scores were comparable.

Conclusion:

Fascial plane blocks in the form of pectoralis II and proximal intercostal block facilitate pain alleviation, early return to shoulder arm exercise, and enhanced recovery, which should render them to be incorporated into multimodal interdisciplinary pain management in breast conservation surgery.
Prevalence of aspergillus sensitization and allergic bronchopulmonary aspergillosis in bronchial asthma: A systematic review of Indian studies
Authors: Agarwal Ritesh , Muthu Valliappan , Sehgal Inderpaul S. , Dhooria Sahajal , Prasad Kuruswamy T. , Soundappan Kathirvel , Rudramurthy Shivaprakash M. , Aggarwal Ashutosh N. , Chakrabarti Arunaloke
Published: August 2023

Background:

The prevalence of allergic bronchopulmonary aspergillosis (ABPA) in Indian asthmatic patients remains unknown. We systematically reviewed the literature for estimating the prevalence of Aspergillus sensitization (AS) and ABPA in Indian subjects with bronchial asthma.

Methods:

We searched the PubMed and Embase databases for studies from India reporting the prevalence of AS or ABPA in at least 50 asthmatics. The primary outcome of our study was to assess the prevalence of ABPA. The secondary outcomes were to evaluate the prevalence of AS in asthma and ABPA in Aspergillus-sensitized asthma. We pooled the prevalence estimates using a random effects model and examined the factors influencing the prevalence using multivariate meta-regression.

Results:

Of the 8,383 records retrieved, 34 studies with 14,580 asthmatics met the inclusion criteria. All the studies were from tertiary centers. The pooled prevalence of ABPA in asthmatics (26 studies; 5,554 asthmatics) was 16.2% [95% confidence interval (CI), 12.5–20.4]. The pooled prevalence of AS in asthma (29 studies; 13,405 asthmatics) was 30.9% (95% CI, 25.3–36.6), while the prevalence of ABPA in AS (20 studies; 1,493 asthmatics) was 48.2% (95% CI, 39.6–56.8). Meta-regression identified studies published after 2009 (OR 1.14; 95% CI, 1.02–1.28) and studies with severe asthmatics (OR 1.12; 95% CI, 1.00–1.26) as the only factors associated with higher ABPA prevalence.

Conclusions:

We found a high prevalence of ABPA in Indian asthmatic subjects at tertiary centers, underscoring the need for screening all asthmatic subjects in special asthma and chest clinics for ABPA.
Block perturbation of symplectic matrices in Williamson’s theorem
Authors: Babu Gajendra , Mishra Hemant K.
Published: August 2023

Williamson’s theorem states that for any$2n \times 2n$real positive definite matrixA, there exists a$2n \times 2n$real symplectic matrixSsuch that$S^TAS=D \oplus D$, whereDis an$n\times n$diagonal matrix with positive diagonal entries known as the symplectic eigenvalues ofA. LetHbe any$2n \times 2n$real symmetric matrix such that the perturbed matrix$A+H$is also positive definite. In this paper, we show that any symplectic matrix$\tilde {S}$diagonalizing$A+H$in Williamson’s theorem is of the form$\tilde {S}=S Q+\mathcal {O}(\|H\|)$, whereQis a$2n \times 2n$real symplectic as well as orthogonal matrix. Moreover,Qis insymplectic block diagonalform with the block sizes given by twice the multiplicities of the symplectic eigenvalues ofA. Consequently, we show that$\tilde {S}$andScan be chosen so that$\|\tilde {S}-S\|=\mathcal {O}(\|H\|)$. Our results hold even ifAhas repeated symplectic eigenvalues. This generalizes the stability result of symplectic matrices for non-repeated symplectic eigenvalues given by Idel, Gaona, and Wolf [Linear Algebra Appl., 525:45–58, 2017].
Vandermonde’s identity proved by complex analysis
Authors: Chakraborty Bikash , Roy Soumon
Published: August 2023

In this short note, we propose a proof of the Vandermonde identity based on elementary complex analysis.
Box dimension of generalized affine fractal interpolation functions
Authors: Jiang Lai , Ruan Huo-Jun
Published: August 2023

Let

f

be a generalized affine fractal interpolation function with a vertical scaling function

S

. In this paper, we study

\mathrm{dim}_B \Gamma f

, the box dimension of the graph of

f

, under the assumption that

S

is a Lipschitz function. By introducing vertical scaling matrices, we estimate the upper and the lower bounds of oscillations of

f

. As a result, we obtain an explicit formula of

\mathrm{dim}_B \Gamma f

under certain constraint conditions.
The conditional measures for the determinantal point process with the Bergman kernel
Authors: Bufetov Alexander I.
Published: August 2023

This note gives an explicit description of conditional measures for the determinantal point process with the Bergman kernel.
MEDIDAS DE PROTECCIÓN FRENTE A LA VIOLENCIA FAMILIAR, UNA REVISIÓN DE LA LITERATURA EN AMÉRICA LATINA 2018 - 2023
Authors: Alarcón Camacho Daniela Stephany , Alza Collantes Carlos Jesús
Published: August 2023

En los últimos años, ha habido un aumento en el número de casos de violencia familiar a nivel mundial, lo cual no es solo un problema social, pues a pesar de las medidas para proteger a las víctimas; en la práctica, se constató que la protección aún no era efectiva. Por ello, el objetivo del estudio fue identificar las medidas de protección frente a la violencia familiar en América Latina 2018 – 2023. La metodología que se aplicó fue PRISMA, tuvo como método de estudio a la revisión sistemática, que se utilizó como data de búsqueda en Redalyc, Scielo, La Referencia, Alicia Concytec y Google académico. Los criterios de elegibilidad fueron: artículos en idioma español entre los años 2018 a 2023, asociados a revisiones sistemáticas y artículos científicos, que contemplan las palabras claves, asimismo, los resultados que fueron medidos mediante criterios de inclusión / exclusión en dónde se analizaron 30 artículos. Se concluyó que, se identificaron como medidas de protección frente a la violencia familiar en América Latina a las siguientes: creación de juzgados especializados en familia, el retiro del agresor de la vivienda donde reside la víctima y disposiciones amparadas en la ley 30364.
CIBERCONVIVÊNCIA SCREENAGERS
Authors: Silva Liliane Inácia da , Carvalho Fabrísia Maria da Silva , Siva Fabrício Cardoso da
Published: August 2023

Este trabalho explora as habilidades de conectividade, comunicação e desenvolvimento das atividades oferecidas por meio de telas pela geração Screenagers. Seu objetivo é pesquisar e abordar os desafios e possibilidades enfrentados pelos professores ao colaborar na formação Screenagers, e as contribuições da Inteligência Artificial no processo de ensino e aprendizagem. A metodologia adotada baseia-se em pesquisa bibliográfica, com foco na análise qualitativa de conceitos relevantes para o tema. O embasamento teórico é construído a partir de livros e artigos disponíveis em plataformas virtuais, abrangendo autores como Castro (2012), Moran (2000), Mattar (2012) e Bacich et al. (2015). Este trabalho está dividido em três partes principais: a primeira apresenta uma breve definição do conceito de Geração Screenagers; a segunda discute os desafios e possibilidades da prática docente no contexto dessa geração; e a terceira aborda a contribuição da Inteligência Artificial no processo de ensino e aprendizagem Screenagers. A pesquisa revela diversos desafios enfrentados pelos professores atualmente e enfatiza a necessidade de formação contínua para explorar as possibilidades no uso da tecnologia, especialmente a Inteligência Artificial, para transformar o ambiente escolar e promover o ensino.
A METODOLOGIA ATIVA, A APRENDIZAGEM SIGNIFICATIVA E SALA DE AULA INVERTIDA
Authors: Parreira Daiana Cristina , Barros Ayrla Morganna Rodrigues , Santos Domingos Sávio dos , Costa Janmes Wilker Mendes , Sales Raimundo Sampaio
Published: August 2023

Esse estudo tem como objetivo discutir sobre as novas metodologias de ensino, a aprendizagem significativa, bem como a sala de aula invertida e sua relevância para o ensino aprendizagem. As metodologias ativas tem como papel fundamental proporcionar ao aluno uma experiência de aprendizagem que o direciona para a autonomia do conhecimento construído através de sua vivencia e de seu protagonismo frente sua própria aprendizagem, tornando-a significativa e prazerosa. A sala de aula invertida proporciona ao estudante estudar previamente os conteúdos que serão discutidos nas aulas subsequentes, levando o aluno já estabelecer as conexões e elencar dúvidas a fim de chegar a resoluções de problemas e pôr em prática o aprendizado adquirido. Diante disso, buscamos confrontar ideias de vários estudiosos renomados no assunto e promover um alinhamento de ideias sobre essa temática. Logo, chegamos ao entendimento de que a aprendizagem significativa deve promover aos alunos experiências concretas, para isso as metodologias ativas como a sala de aula invertida permite ao estudante a experimentação, oportuniza elencar a problemática, tirar dúvidas, discutir resoluções de problemas e ainda possibilita também a aprendizagem colaborativa.
A CIBERCONVIVÊNCIA DOS “SCREENAGERS”
Authors: Bertolazzi João Carlos , Silva Marcos Vinicius Malheiros da , Oliveira Rebeca Maria de , Narciso Rodi , Crimoni Rosangela Miranda
Published: August 2023

A mudança de comportamento entre as pessoas estão tomando rumos de distanciamento e a aproximação física cada vez mais distante o virtual muito presente hoje conversamos ou teclamos sem saber quem esta do outro lado as velocidade de informações nós traz a refletir sobre mudanças, conhecimentos pessoas virtualmente é saudável para obter a percepção do certo ou errado como isso afeta na educação no trabalho e nosso lado logico foram se por terra não havendo a necessidade de pensar formação comportamento solitário ou grupo é que nos cerca para obter informações? E quando voltamos essas mesmas ações para pessoas portadoras de TEA como podemos entender o universo que eles vivem as condições que devemos analisar. O processo transformador no ambiente social ocorre com processo 1.0 ate 4.0 e 5.0 que contribuiu na revolução Industrial e na Educação o caminho que estamos seguindo as ações nos mostra que a mudança de comportamento e a liberdade atingiram a maneira de ensinar e aprender a das novas tecnologias nos mostrara uma realidade virtual mais pragmática ao ser humano, com isso temos de entender as ações do comportamento e refletir se não estamos perdendo a capacidade da logica o raciocínio na participação da ação na Educação se alinhara alguns fatores que jamais deixará de existir Escola, Professores e Alunos a maneira de ensinar sim como já ocorre deixando a sensação de protagonismo com os alunos e porém a ação direcionamento e protagonista sempre será do professor.
APRIMORANDO A TOMADA DE DECISÕES EMPRESARIAIS
Authors: Santana Aline Abreu , Silva Cristiane Raquel da , Timoteo Luciene Carneiro da S. O. , Oliveira Rebeca Maria de , Narciso Rodi
Published: August 2023

No século 21, os gestores enfrentam desafios significativos devido à acirrada competitividade impulsionada pelos avanços tecnológicos. A habilidade do gestor em tomar decisões acertadas e aumentar a produtividade e o êxito das empresas torna-se fundamental para a longevidade dos empreendimentos. A sobrevivência dos negócios requer decisões fundamentadas na análise de recursos financeiros passados, presentes e futuros, prevendo possíveis dificuldades financeiras. O presente estudo bibliográfico objetiva abordar a análise de negócios como meio para compreender a estrutura, políticas e operações de uma organização, recomendando soluções que alcancem os objetivos estratégicos. Por meio de uma revisão bibliográfica aprofundada, exploraremos como a análise de negócios, apoiada por tecnologias e dados, capacita os gestores a tomar decisões mais informadas e embasadas. Destacaremos também a importância de prever cenários financeiros, identificar oportunidades de melhoria e mitigar riscos potenciais. Mencionaremos brevemente o caso da School 21, uma empresa educacional que se destaca ao utilizar tecnologias e análises de negócios para aprimorar suas condições operacionais e alcançar decisões empresariais mais assertivas, resultando em sucesso organizacional. O estudo visa contribuir para o entendimento da relevância das análises de negócios e tecnologias na tomada de decisões, oferecendo insights valiosos para gestores e profissionais que buscam potencializar o sucesso e a sustentabilidade de suas empresas na era moderna.
BASE NACIONAL COMUM CURRICULAR (BNCC) E O ATUAL CURRÍCULO BRASILEIRO PÓS PANDEMIA
Authors: Dieterich Daniela , Batista Klener , Meroto Monique Bolonha das Neves , Alves Renata Camargo Costa , Trentin Tamara
Published: August 2023

Uma educação pública de qualidade é um tema que vem sendo estudado e debatido há muitos anos na história da humanidade, muitas horas de estudos foram empregadas traçando estratégias e metodologias para tal objetivo em nosso país. No dia 06 de abril de 2017, a proposta da BNCC, Base Nacional Comum Curricular, foi entregue pelo o Ministério da Educação ao Conselho Nacional de Educação e desde então, todas as atenções estão voltadas para essa proposta curricular de melhoria no ensino público de qualidade, ainda mais após o período que o mundo viveu em pandemia do COVID-19. A BNCC define o direito de aprendizagem e as competências a serem desenvolvidas pelos estudantes em cada modalidade da Educação básica, estabelecendo os conteúdos mínimos nacionais e os específicos em âmbito local e regional, e junto ao Plano Nacional de Educação estabelece as metas e estratégias para serem alcançadas. Mas ainda a BNCC instiga muitas dúvidas entre os profissionais da área da educação. O que é a BNCC? Para que serve? Porque foi criada? Qual é a lei que regulamenta a BNCC? Ela é mesmo importante? A BNCC faz-se realmente presente no currículo brasileiro atual? Estou trabalhando de acordo com a proposta da BNCC? Para responder essas e outras indagações, é de suma importância a realização deste trabalho de pesquisa, que irá nortear as práticas pedagógicas e o currículo dos profissionais dessa área, levando a uma reflexão do currículo e das metodologias empregadas dentro das instituições de ensino de todo o país. A implementação da BNCC não melhora a educação por si só, mas a sua execução junto com investimento em politica salarial, formação continuada dos profissionais e infraestrutura nas escolas são fatores que colaboram para sanar a defazagem gerada em nossas escolas devido ao período pandêmico do Covid 19.
CRIANDO UM AMBIENTE DE APRENDIZAGEM MOTIVADOR
Authors: Oelke Eliane
Published: August 2023

Neste artigo de revisão, exploramos o papel do professor no e-learning como mediador e facilitador do engajamento dos estudantes. Observamos que, apesar das vantagens oferecidas pelas plataformas de e-learning, o papel do professor continua sendo fundamental na criação de um ambiente de aprendizagem motivador. O estudo para este paper teve como metodologia a revisão bibliográfica realizada a partir do referencial teórico abordado na disciplina EDU620 – Teorias da Aprendizagem e o Design de Ambientes de E-learning e selecionado de acordo com as discussões sobre o contexto. Foram utilizados os descritores ‘e-learning’, ‘professor’, ‘engajamento dos estudantes’ nas bases de dados do portal de periódicos da CAPES/MEC e Google Acadêmico. Considerando alguns critérios de inclusão para serem utilizados, como: artigos publicados a partir de 2013; em periódicos nacionais, publicados em português e que se encontravam na íntegra e com os devidos endereços eletrônicos abertos ao público sem a necessidade de cadastros para acesso. A coleta desses dados foi realizada no mês de maio de 2023. o papel do professor no e-learning vai além de transmitir informações. Ele desempenha um papel crucial como mediador, facilitador e motivador dos estudantes, promovendo a participação ativa, a interação e a colaboração no processo de aprendizagem. Através dessa abordagem, podemos explorar todo o potencial das tecnologias educacionais, tornando a educação uma experiência enriquecedora e transformadora.
Fatores Associados Ao Uso Do Fio Dental Entre Adolescentes
Authors: Oliveira Santos Palma Liliane Cristina de , Oliveira Santos Ana Paula de , Gonçalves Fonseca Maia Naiara , Ferreira da Silva Junior Rene , Souza Santos Lara Isabella , Oliveira Carolina de Castro , Oliveira e Silva Carla Silvana de , Sant'Ana Haikal Desirée
Published: August 2023

Objetivo: identificar os fatores associados ao uso do fio dental entre adolescentes. Método: Estudo transversal com amostra representativa de adolescentes de escolas públicas de um município mineiro de médio porte. Adotou-se amostragem probabilística por conglomerado em múltiplos estágios. A variável dependente foi o uso auto referido de fio dental. As variáveis independentes foram agrupadas em condições sociodemográficas, uso dos serviços odontológicos, comportamentos em saúde, condições subjetivas de saúde geral e condições objetivas de saúde bucal. Conduziu-se regressão logística binária. Resultados: entre os 600 adolescentes incluídos, 47,2% referiram uso do fio dental. Houve maiores chances de uso de fio dental entre adolescentes do sexo feminino (OR = 1,5), que usaram o serviço odontológico a menos de um ano (OR = 2,1); que apresentavam frequência de escovação dentária duas ou mais vezes ao dia (OR = 2,9) e que relataram dor de dente nos últimos seis meses (OR = 1,7). Conclusão: o uso do fio dental entre adolescentes esteve mais associado a comportamentos de autocuidado com a saúde bucal e a ocorrência de dor, do que a outras questões objetivas ou subjetivas de saúde bucal. O uso do fio dental não é ainda um comportamento amplamente adotado, necessitando de maior incentive.
The acquisition of spatial and mountain literacy by children in Hergé’s Tintin in Tibet.
Authors: Heath Gavin
Published: August 2023

The acquisition of spatial and mountain literacy by children in Tintin in Tibet is related to broader geospatial reasoning which has import later in life. The literature review for this paper covers the theories of spatial literacy and ability, as well as the developing field of mountain literacy. Methodologically, the comic book was analysed in terms of spatial literacy and then mountain literacy, chiefly in terms of altitudinal band differences, risk and danger, through page progression. Key findings were that this particular comic book is full of references to spatial and mountain literacy theories. Young readers who take careful note of the comic book could gain a head start in geography, in particular to what pertains to mountains (climate, vegetation, risk, danger) in Europe and Asia, both lowland and highland, but also in terms of diverse urban and regional forms.
Exploring the inner workings of the Southern African Geography Teachers’ Association Google Group
Authors: Wilmot Di , Goldschagg Paul
Published: August 2023

We live in a socio-ecologically fragile and rapidly changing world that can be turned upside down in an instant as we witnessed with the crisis of the COVID-19 pandemic. Today, more than ever before, teachers need to be life-long learners who have the necessary geography subject knowledge, pedagogical knowledge and resources for responsive teaching and learning in their classrooms. Professional Learning Communities (PLCs) play an important enabling role in this regard. This article presents the findings of the second phase of an ongoing study aimed at understanding how the South African Geography Teachers’ online Google Group, an emergent Professional Learning Community, may support and enhance geography education and teacher professional development. More specifically, it opens up and looks inside the ‘black box’ of the Google Group, the workings of which are not yet fully understood. It considers the supportive role played by the Google Group during and after the COVID-19 pandemic (that is, March 2020 to December 2021 and January to November 2022). 

Data generated by the posts made during and after the pandemic, were analysed and categorised. Emergent patterns and trends in and between the two periods were identified and discussed. A purposive sample from each category was selected for further in-depth analysis.  We draw on Shulman and Shulman’s (2004) theory of teacher knowledge as an analytical lens for interpreting the findings. The findings are discussed in relation to national imperatives (for example, teacher professional development, social justice, inequality and learner underperformance) and global education discourses for transformative education.

Our main contention in this article is that the Google Group PLC offers support for teachers. However, there are gaps that need to be addressed if it is to play a stronger supportive and transformative role. We conclude with some suggestions on how this may be achieved in practice which may be useful to members of the geography education community particularly teachers.

Key words: teacher knowledge, teacher professional development, professional learning community, COVID-19 pandemic