bluuebunny/crossref_metadata_2025 huggingface dataset:
Brucella abortushijacks the host protein Slc2a1via the SepA effector to promote intracellular survival in macrophages
Authors: Yang Yuanhao , Zu Yaping , Wang Xin , Wang Hui , Liu Xiaofang , Tang Ting , Zhai Yunyi , Wudong Gaowa , Wang Pingping , Yuan Ningqiu , Zhou Dong , Jin Yaping , Wang Aihua
Published: January 2025

Brucella spp. are facultative intracellular bacteria that infect and induce brucellosis in a diverse range of mammalian hosts. The disease causes major global economic losses and also is a worldwide threat to public health security. Characterization of bacterial and host factors that promote intracellular survival of Brucella is key for the prevention and control of brucellosis. In this study, we identified proteins involved in intracellular survival of Brucella abortus A19 in RAW264.7 macrophage cells by liquid chromatography-mass spectrometry of macrophages with or without B. abortus infection. The functions of these proteins, the signaling pathways in which the proteins participate, the domain entries enriched by the proteins, and the subcellular localization of the differentially-expressed proteins were deciphered. Differential protein expression revealed that Slc2a1, which is a key Glycolytic protein, was significantly upregulated in infected macrophage cells. This observation was confirmed by qRT-PCR and Western blotting studies. The role of Slc2a1 in the intracellular survival of B. abortus was probed by overexpressing and knocking down SLC2A1 in RAW264.7 cells. Overproduction of the protein promoted intracellular proliferation of B. abortus whereas knockdown of SLC2A1 inhibited proliferation of the bacterium. Finally, we determined that the Secreted Effector Protein A (SepA) effector of B. abortus enhanced SLC2A1 expression in macrophage cells. Thus, B. abortus stimulates host SLC2A1 expression via the SepA effector protein to aid bacterial survival in the macrophage environment which suggests that SepA may be a novel antibacterial target to combat Brucella infection.
Nomogram for Predicting Lymph Node Metastasis in Cervical Cancer: Comparison of 2009 and 2018 Staging Systems
Authors: Li Suyu , Chen Yusha , Chen Xiaoying , Li Xiaoyan , Zhou Guangrun , Huang Liyuan , Huang Qiuyuan , Huang Xizhen , Huang Zhijian , Liu Zhaodong , Zheng Xiangqin
Published: January 2025

OBJECTIVES
Lymph node metastasis (LNM) is crucial for personalized
treatment in cervical cancer (CC) patients; this study evaluates
the enhancement of LNM prediction models by integrating the 2018
FIGO staging system into those based on the 2009 FIGO cohort and
assesses the models' net benefit.

METHORDS: We included 691 patients: 348 with 2009 FIGO stage IB1-IIA2 CC (Cohort 1) for model development and external validation, and 343 with 2018 FIGO stage IB1-IIICr CC (Cohort 2) for external validation. Variables were selected using regression analyses and LASSO methods. Nomogram models were evaluated with ROC curves, C-index, Integrated Discrimination Improvement (IDI), and Net Reclassification Index (NRI). RESULTS: Model 1 included tumor size, depth of stromal invasion (DSI), SCC-Ag, and neutrophil-to-lymphocyte ratio (NLR). Model 2 incorporated the FIGO staging system. Model 1 showed suitable calibration with discrimination accuracy of 0.807 in the training cohort and 0.772 in the testing cohort. External validation yielded an AUC of 0.743. Model 2, with the 2018 FIGO image staging, demonstrated superior performance for predicting LNM, with a discrimination accuracy of 0.877, significant ΔC-index (P = 0.0024). Adding the 2009 FIGO clinical staging did not significantly enhance predictive value (ΔC-index P = 0.896). Model 2's predictive performance improved by 23.18% in the low-to-intermediate risk group and 17.24% in the high-risk group. CONCLUDSION: Incorporating the 2018 FIGO image staging system into the 2009 FIGO clinical staging model significantly improved LNM prediction, highlighting the importance of imaging-based staging systems and facilitating their application across different time periods.
Impact of Various Qigong and Tai Chi Exercises on Motor Function, Depression, and Quality of Life in Parkinson's Disease Patients: A Network Meta-Analysis
Authors: Zhao Jiankang , Yang Ming , Li Ziye , Lu Jun , Kong Yafei , Tian Zhuyun , Zhang Changrun
Published: January 2025

Fitness Qigong and Tai Chi, as forms of exercise therapy, are suitable for Parkinson's disease (PD) patients who are mainly middle-aged and elderly, and their effectiveness has been proven by an increasing number of studies. However, there is a serious issue in some previous studies, which is the misconception of considering Fitness Qigong and Tai Chi as a specific form of exercise. In fact, Fitness Qigong and Tai Chi are not single forms of exercise, but rather a general term for a category of exercises. Since the fitness effects of different types of Fitness Qigong and Tai Chi are not exactly the same, it is necessary to conduct a more specific classification of Fitness Qigong and Tai Chi and then perform a network Meta-analysis to explore the effects of different types of Fitness Qigong and Tai Chi on treating different symptoms of PD. By comprehensively collecting and organizing literature from English and Chinese databases such as Pubmed, Embase, Cochrane Library, Web of Science, CNKI, and Wan Fang, with the literature search cut-off date being November 22, 2024, and extracting data from the finally included randomized controlled trials. According to the Cochrane Risk of Bias Assessment Tool in the Cochrane Handbook, the methodological quality and bias risk of the included literature were evaluated using RevMan 5.4 software, and finally, Stata 18.0 software was used for network Meta-analysis. During the analysis, subgroup analyses were conducted based on different intervention types, intervention periods, Hoehn-Yahr stages, and patient disease courses to explore the sources of heterogeneity. The 35 studies included in this article involved 4 types of Fitness Qigong exercises and 4 types of Tai Chi exercises, with a total of 1,763 patients with mild to moderate Parkinson's disease. The results of the network Meta-analysis showed that compared with the conventional treatment of Parkinson's disease, 24-Form Tai Chi Qigong (24-FTJQ) was the best treatment plan for improving UPDRS Ⅲ scores and Berg Balance Scale (BBS) scores; 42-Form Tai Chi Qigong (ATJQ) was the best treatment plan for improving Gait Velocity; Wu Qin Xi (WQX) was the best treatment plan for improving Timed Up and Go Test (TUGT) scores; Ba Duan Jin (BDJ) was the best treatment plan for improving Depression scores; and Yi Jin Jing (YJJ) was the best treatment plan for improving PDQ-39 scores. Therefore, in clinical practice, more suitable exercise plans can be formulated according to the main symptoms of patients, reducing the treatment period.
An Implementation Of Patient Blood Management Program In Total Hip and Total Knee Replacement Patients
Authors: Kougioumtzis Ioannis , Chatzipapas Christos , Tzatzairis Themistoklis , Tottas Stylianos , Iliopoulos Efthymios , Tilkeridis Konstantinos , Ververidis Athanasios
Published: January 2025

Introduction
The implementation of patients’ blood management (PBM) is being leaded in a considerable decline of both blood loss and allogenic blood transfusion in primary Total Hip (THR) and Knee Replacement (TKR). The aim was to outline the results after a stepwise implementation of PBM protocol in THR and TKR.
Material and Methods
We conducted a retrospective study. A PBM protocol regarding the entire blood bleeding, the use of tranexamic acid (TXA) (0gr or 1gr or 2gr), the preoperative anaemia and a transfusion trigger (from 10 to 8 Hb gr/dl) was applied. Patients and surgery related data were prospectively recorded and analyzed.
Results
427 patients underwent either TKR (n:260) or THR (n:167). In both TKR and THR presented gradual reduction (a) blood loss from 1.430 to 1.129 and from 1.277 to 1.101 respectively, (b) transfusion rate from 30.4–0.2% and from 35.7–0.1% respectively and (c) mean hospitalization from 5 to 2.97 days and from 4.8 to 2.87 days respectively. In TKR, pre-operative anaemia was an independent determinant of bleeding, as were BMI > 30, ASA > II and no-TXA use. Independent determinants of transfusion rate were pre-operative anemia and no-TXA use. In THR, independent determinants of hemorrhage were male, BMI > 30, operation > 90 minutes, transfusion rate, pre-operative anaemia and no-TXA use.
Conclusion
The implementation of a restrictive PBM protocol addressing the “modifiable” factors of increased blood loss and transfusion rate such as pre-operative anemia, TXA use, short surgical time and low transfusion trigger can substantially reduce the transfusion of allogenic blood.
Level of Evidence
II
Oral antibiotics combined with mechanical bowel preparation reduces the risk of surgical site infections in minimally invasive colorectal cancer surgery
Authors: Park Eun Ji , Park Min Young , Han Yoon Dae , Cho Min Soo , Hur Hyuk , Min Byung Soh , Lee Kang Young , Yang Seung Yoon
Published: January 2025

Purpose
Colorectal surgeries are associated with high rates of surgical site infection (SSI), which significantly impact postoperative recovery and outcomes. Use of preventive measures, such as mechanical bowel preparation (MBP) and preoperative oral antibiotics (POA), is widely debated. This study investigated the effectiveness of POA plus MBP before elective minimally invasive colorectal cancer surgery.
Methods
This study retrospectively analyzed 1,506 patients who underwent elective minimally invasive colorectal cancer surgery between January 2020 and December 2023 to evaluate the effectiveness of MBP plus POA in preventing SSIs and other postoperative complications. Patients were divided into MBP alone (n = 811) and POA + MBP (n = 695) groups.
Results
Overall SSI rates were significantly lower in the POA + MBP group than in the MBP alone group (11.6% vs. 5.5%, p = 0.008), with significant reductions in grade 1–2 SSIs. POA + MBP was particularly effective in patients undergoing colon cancer surgery. In this subgroup, POA + MBP was associated with a 5.6% lower rate of SSIs than MBP alone, with no difference in anastomosis leakage rates between regimens. In patients undergoing rectal cancer surgery, POA + MBP was associated with a significantly higher anastomosis leakage rate (6.9% vs. 2.2%, p = 0.016), with no difference in SSI rates between regimens. Multivariable analysis confirmed that MBP alone was a risk factor for SSIs (odds ratio, 1.5; 95% confidence interval, 1.13–2.18; p = 0.007).
Conclusion
This study highlights the differential effects of POA + MBP in minimally invasive surgery for colon versus rectal cancer and underscores the need for further investigations to determine the optimal bowel preparation regimen for specific surgical sites.
Two-sample Mendelian randomization analyses support cross-talk between air pollution exposure and gut microbiome
Authors: Gu Shaowei , Cui Yikun , Chen Hui , Bai Hao , Yin Xiaolin , Yang Xiaorong
Published: January 2025

Background
Various studies have suggested the intriguing potential of air pollution exposure to influence gut microbiota diversity. It can impact gut microbiota not only by directly entering the intestine, but also through the gut-lung axis when deposited in lungs. Nevertheless, the scarcity of compelling genetic causal evidence remains conspicuous. Our objective was to evaluate whether a genetic causal relationship exists between air pollution and gut microbiota, along with the potential implications of this connection.
Method
This study was designed to investigate the link between air pollutant exposure (encompassing PM2.5, PM10, PM2.5−10, NO2, and NOx) and alterations in the gut microbiome using a two-sample Mendelian randomization method based on summary-level GWAS study. To explore the effect of air pollutants on gut microbiota, we conducted MR analyses across five specific feature levels, including phylum, class, order, family, and genus. The main analytical approach employed was inverse variance weighting (IVW), which examined the relationship between exposure and outcome by assessing single nucleotide polymorphisms (SNPs) linked to air pollution.. Additional sensitivity analyses, such as Cochran Q test, MR-Egger regression, and leave-one-out analysis, were conducted to evaluate the robustness of the findings.
Results
A statistically noteworthy association was observed between NO2 exposure and an uptick in the genus Eubacterium fissicatena group [IVW-odds ratio (OR) = 2.20; 95% confidence interval (CI), 1.42–3.41; P = 4.36*10− 4], the Gordonibacter genus (IVW-OR = 2.29; 95%CI: 1.48–3.56; P = 2.17*10− 4), and the LachnosPiraceae genus (IVW-OR = 1.82; 95%CI: 1.32–2.51; P = 2.37*10− 4). Contrarily, a decrease in the abundance of the Holdemania genus (IVW-OR = 0.616; 95%CI: 0.47–0.81; P = 6.58*10− 4) and the Ruminococcus gauvreauii genus (IVW-OR = 0.663; 95%CI: 0.53–0.83; P = 4.63*10− 4) was linked with NO2 exposure. Furthermore, PM2.5 exposure was associated with a lower presence of Family XIII (IVW-OR = 0.691; 95%CI: 0.55–0.87; P = 1.47*10− 3).
Conclusion
Our findings indicate air pollutants, particularly NO2 and PM2.5, appeared to have a noteworthy association with the gut microbiota's composition, especially for genus Eubacterium fissicatena group, Gordonibacter genus, LachnosPiraceae genus, Holdemania genus and the Ruminococcus gauvreauii genus. This may offer valuable insights for further investigations into the mechanisms and clinical implications of air pollution-induced dysbiosis of the gut microbiome.
The Effect of Government Expenditure on Economic Growth in Myanmar: a Fiscal Decentralization Perspective
Authors: Phyu May Zin
Published: January 2025

This study's primary goal is to understand how government expenditure affects economic growth in Myanmar from the standpoint of fiscal decentralization and local governments' financial capability in the country. Also, by using 15 Myanmar regional state panel data and an econometric model for the years 2000–2021. The study commenced with the application of a fixed effects model, followed by the implementation of quantile regression to validate the robustness of the findings. Data was collected utilizing secondary sources from the government's Ministry of Planning and Finance as well as the Budget Department. The results of the analysis demonstrate that financial decentralization, government spending, centralization and decentralization, foreign direct investment, and the overall population all significantly and favorably affect economic growth in Myanmar, whereas labor and net exports have the negative effect. Government spending and fiscal decentralization, however, interact to produce economic growth in a statistically meaningful beneficial way. Recommendations, government spending, and the decentralization for economic growth significantly contribute to formulating measures for poverty alleviation. The region offers assistance to low-income or employed people without income access, and it has demonstrated efficacy as a significant strategy for poverty reduction in Myanmar regional state. Finally, the government can benefit from regional expenditures and fiscal decentralization to enhance competitiveness in development by elevating knowledge of regional supervisory capabilities beyond mere certifications, thus fostering regional autonomy and transforming national economies.
Triple pillars of sustainable finance: The role of green finance, CSR, and digitalization on bank performance in Bangladesh
Authors: Masrick Hasan Shaikh , M. Anwarul Islam K. , Taleb Tawfiq Tawfiq , Saha Priya
Published: January 2025

This study examines the impact of sustainable finance factors on bank performance in Bangladesh. It utilizes annual data from 24 listed commercial banks in Bangladesh from 2016 to 2022. It focuses on three sustainable finance factors: green finance, corporate social responsibility (CSR), and digitalization. These factors ensure sustainable finance practices by prioritizing eco-friendly investments, responsible business operations, operational efficiency, and reduced resource consumption rather than focusing solely on short-term profit maximization. Return on assets (ROA) and return on equity (ROE) are used to measure the performance of commercial banks. This study incorporates default rate and bank size as control variables to consider inherent risk and operational scale, resulting in a more precise evaluation of the impact of digitization, CSR, and green financing on bank performance. Traditional and dynamic panel regression models, including feasible generalized least squares (FGLS) and random effects models, are applied to ensure robust findings. The findings indicate that green finance exhibits an insignificant impact on bank performance. However, corporate social responsibility (CSR) demonstrates a statistically significant positive effect on ROE through positive marketing, enhancing reputation, and building shareholder loyalty towards banks. Conversely, digitalization shows a statistically significant negative effect on performance, implying that initial implementation costs and challenges may outweigh the benefits. In addition, control variables, including default rate and bank size, exhibit a statistically significant negative relationship with performance measures. This suggests that higher default rates indicate increased credit risk and financial losses, while larger bank sizes may lead to inefficiencies due to agency costs and organizational complexities.
A Review of Regenerative Braking Methods for Induction Motors in Electric Propulsion System
Authors: Nur Sabilillah Muhammad Rifqi , Rini Nur Hasanah
Published: January 2025

This paper provides a comprehensive review of regenerative braking methods for induction motors utilized in electric propulsion systems. Regenerative braking is a crucial technology for enhancing the energy efficiency of electric vehicles (EVs) and hybrid electric vehicles (HEVs) by converting kinetic energy back into electrical energy during braking. The review focuses on several regenerative braking techniques, including self-excited regenerative braking using capacitors and inverter-based regenerative braking. By evaluating the efficiency, cost-effectiveness, and practical applications of these methods, the paper identifies the strengths and weaknesses of each approach. Additionally, recent advancements in the field are discussed, along with suggestions for future research directions to optimize energy recovery in electric propulsion systems. The goal is to provide valuable insights for engineers and researchers working towards the development of more efficient and cost-effective regenerative braking systems, ultimately contributing to the advancement of electric and hybrid vehicle technologies.
ЕФЕКТИВНІСТЬ ЗАСТОСУВАННЯ L – АРГІНІНУ (АРГІНІНУ ГІДРОХЛОРИДУ) У ХВОРИХ НА COVID-19 ІЗ СУПУТНІМ ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ
Authors: З.Р. Тиліщак  , О.Я. Пришляк
Published: January 2025

Перебіг коронавірусної хвороби (COVID-19) у пацієнтів із цукровим діабетом 2 типу (ЦД2) характеризується ризиком тяжкого перебігу та ускладнень. Мета. Підвищити ефективність лікування хворих на COVID-19 за допомогою включення в схему лікування препарату L-аргініну на основі вивчення клінічних та патогенетичних особливостей перебігу поєднаної патології із супутнім ЦД2. Матеріали і методи. Обстежено 60 хворих на COVID-19 із супутнім ЦД2. Основна група (30 осіб) на тлі протокольної терапії отримувала довенно краплинно препарат L-аргініну. Контрольна група (30 осіб) отримувала базову терапію. Хворим проведено загальноклінічні лабораторні дослідження, визначення біохімічних показників, коагулограми,  феритину, СРБ, прокальцитоніну, Д-димеру, ендотеліну-1, інтерлейкіну-6, капіляроскопію нігтьового валика. Результати. В основній групі відмічали достовірне зменшення проявів дихальної недостатності у пацієнтів із ДН І ступеня, достовірний позитивний вплив L-аргініну на рівні інтерлейкіну-6, СРБ, прокальцитоніну, ендотеліну-1. При капіляроскопії нігтьового валика після лікування у хворих основної групи достовірно зменшилися перикапілярний набряк, відкладення гемосидерину, збільшилися довжина капілярів, діаметр артеріального відділу, зменшилися показники діаметру венозного та перехідного відділів, збільшилася щільність капілярної мережі, зменшилася міжкапілярна відстань, кількість мікротромбозів і мікрокрововиливів. Висновки. Використання препарату L-аргініну у хворих на COVID-19 із супутнім ЦД2 достовірно зменшує прояви дихальної недостатності, знижує рівень гострофазових показників, зменшує ендотеліальну дисфункцію, мікросудинні порушення, покращує капілярний кровотік.
Оцінка якості життя у хворих на гострий алкогольний панкреатит
Authors: Н.М. Фешовець  , О.В. Пиптюк
Published: January 2025

У сучасній медицині пацієнт-центровані підходи до лікування стають ключовими у забезпеченні якісної діагностики та терапії, що враховує індивідуальні особливості кожного пацієнта. У цьому контексті особливу увагу привертає вивчення впливу гострого алкогольного панкреатиту (ГАП) на якість життя, з огляду на його високий ризик інвалідизації та смертності. Дослідження, спрямовані на оцінку якості життя пацієнтів з ГАП, демонструють суперечливі результати, що підкреслює потребу у стандартизованих методиках оцінювання та вдосконаленні підходів до терапії.
Метою цього дослідження була оцінка впливу модифікованого підходу до лікування на якість життя пацієнтів із ГАП у порівнянні зі стандартизованими протоколами. До дослідження залучено 110 пацієнтів із середнім і важким перебігом ГАП, які перебували на лікуванні у хірургічному стаціонарі. Пацієнтів було розподілено на дві групи: перша отримувала стандартизоване лікування, друга – модифіковану терапію з використанням біоімпедансометрії для корекції інфузійної терапії та застосуванням розчину Стерофундин ISO.
Для оцінки якості життя використовували два стандартизовані інструменти: Gastrointestinal Quality of Life Index (GIQLI) та Gastrointestinal Symptom Rating Scale (GSRS). Опитування проводилося на 1-шу та 14-ту добу перебування пацієнтів у стаціонарі.
Результати показали, що пацієнти з модифікованим підходом до лікування демонстрували значне покращення показників GIQLI та GSRS у порівнянні з групою зі стандартизованою терапією. Динаміка GSRS підтвердила зниження вираженості симптомів шлунково-кишкового тракту у пацієнтів з модифікованим лікуванням. Дослідження підкреслює важливість індивідуалізації терапевтичних стратегій у лікуванні ГАП, що сприяє значному покращенню якості життя пацієнтів. Запровадження біоімпедансометрії як інструменту для корекції інфузійної терапії дозволяє більш ефективно регулювати водно-електролітний баланс, а застосування розчину Стерофундин ISO забезпечує метаболічну стабільність. Отримані результати підтверджують ефективність модифікованого лікування у відновленні якості життя пацієнтів із ГАП, що відображається у зниженні вираженості симптомів, покращенні фізичного, емоційного та соціального стану. Подальші дослідження мають бути спрямовані на вдосконалення методів оцінки стану пацієнтів та розробку інноваційних підходів для підвищення ефективності лікування ГАП.
СОНОГРАФІЧНА ВІЗУАЛІЗАЦІЯ ОРГАНІВ МАЛОГО ТАЗУ У ЖІНОК З НЕПЛІДДЯМ ТА ПЕРЕНЕСЕНИМ ПОСТКОВІДНИМ СИНДРОМОМ
Authors: І.С. Головчак  , О.Г. Бойчук  , Т.Л. Ленчук  , В. М. Мацькевич
Published: January 2025

Тривалий затяжний COVID-19 при неплідді потребує комплексу діагностичних процедур, з яких ультразвукове обстеження є одним з ключових пунктів у встановленні діагнозу та виборі подальшої лікувальної тактики. Мета. Підвищення ефективності та інформативності використання сонографічної візуалізації в оцінці стану органів малого тазу після перенесеного інфікування вірусом SARS-CoV-2 з розвитком постковідного синдрому. Матеріали і методи. Впродовж 2021-2024 років обстежено 80 пацієнток з непліддям та постковідним синдромом та 40 жінок з непліддям без анамнезу COVID-19. Проведено ультразвукове дослідження органів малого тазу з подальшою біопсією та гістологічною верифікацією змінених ділянок ендометрію. Результати. Виявлені шляхом УЗД та ідентифіковані гістологічно вогнища ендометріозу становили достовірну різницю між групами (р=0,045) і зустрічались у 41 (51,3%) жінок дослідної групи та у 12 (30,0%) пацієнток контрольної групи. Між виявленими випадками ендометріозу і хронічного ендометриту виявлено помітний зв’язок r = 0,366 при р˂0,0001. Достовірну різницю між групами виявлено при сонографічних змінах структури ендометрію, які гістологічно інтерпретовано як хронічний ендометрит (р = 0,044). Висновки. Метод сонографічної візуалізації дозволяє встановити локалізацію ендометріозу та хронічного ендометриту, які можуть бути сприяючими чинниками розвитку постковідного синдрому у жінок з непліддям, а також інших широко розповсюджених патологій, які виявляються при неплідді: гіперплазії ендометрію, поліпів, міом різної локалізації у матці, невідповідності товщини ендометрію дню циклу. Ультразвукові знахідки підтверджуються гістологічним методом дослідження зразків тканин для верифікації діагнозу.
ПЕРСПЕКТИВИ РОЗВИТКУ СУДОВОГО МЕДСЕСТРИНСТВА В УКРАЇНІ ЯК ЕЛЕМЕНТА МУЛЬТИДИСЦИПЛІНАРНОГО ПІДХОДУ У ПРОТИДІЇ ҐЕНДЕР-ЗУМОВЛЕНОМУ НАСИЛЬСТВУ ТА НАСИЛЬСТВУ У СІМ’Ї
Authors: Ю.З. Коцюбинська  , М.С. Гараздюк  , І-А.В. Кондрат  , М.І. Поливкан  , І. Б. Іваськевич
Published: January 2025

Анотація. Актуальним питанням сьогодення є впровадження судового медсестринства в Україні з огляду на повномасштабне вторгнення держави-агресора та брак судово-медичних експертів у прифронтових регіонах. Судові медсестри – це дипломовані медичні сестри або висококваліфіковані медичні сестри, які пройшли спеціалізоване навчання для надання допомоги пацієнтам, постраждалим від насильства з гострими та довготривалими наслідками для здоров'я та потребами кримінального правосуддя. Умови імплементації судового медсестринства в Україні це міжвідомче узгодження та закріплення у законодавстві ролі судової медсестри, підготовка групи судових медсестер, які погодяться працювати на прифронтових територіях або на звільнених від окупації територіях, у тому числі для залучення їх у освідуванні звільнених з полону, створення у західному регіоні на базі 2-х університетів Центру підготовки таких судово-медичних сестер за підтримки Міжнародної асоціації Судових медсестер, де під керівництвом дипломованих викладачів судово-медичних експертів та спеціалістів суміжних дисциплін здійснюватиметься підготовка. Впровадження в Україні пілотного проекту з судового медсестринства є нагальною необхідністю, яка дозволить, перед усім, забезпечити своєчасну фахову фіксацію слідів насилля кваліфікованими спеціалістами за умов браку судово-медичних експертів у прифронтових областях.
МОРФОФУНКЦІОНАЛЬНИЙ СТАН ШКІРИ В УМОВАХ ВІКОВОЇ НОРМИ ТА ЗМОДЕЛЬОВАНОГО ГІПОТИРЕОЗУ
Authors: Попадинець Оксана , В.О. Гончарук
Published: January 2025

Дефіцит гормонів щитоподібної залози зумовлює порушення основного обміну, що призводить до змін в організмі. Шкіра є органом-мішенню і, водночас, віддзеркаленням тиреоїдного дисбалансу. Метою роботи було дослідити динаміку змін у шкірі із врахуванням її вікових особливостей та локалізації в умовах змодельованого гіпотиреозу. Експеримент виконано на 64 білих безпородних щурах (по 32 тварини статевонезрілого (4-5 місяців) та статевозрілого (7-8 місяців) віку). По 11 тварин обидвох вікових груп становили 1 групу (контроль), по 21 тварині увійшли у другу, третю, четверту дослідні групи із мерказоліл-індукованим гіпотиреозом і забором матеріалу на 14, 21, 28 доби експерименту. Матеріал дослідження – депільована шкіра спинки, лапок, їх гомогенат, кров. Проведено морфологічне, морфометричне, біохімічне дослідження із статистичною обробкою даних. В ході роботи встановлено структурну перебудову шкіри з віком – змінюється епідермально-дермальне співвідношення, параметри дериватів – сальних та потових залоз, а також кровоносних судин. В умовах гіпотиреозу виявлено стоншення епідермісу та потовщення дерми із прогресуванням до 28 доби. Ілюстративно та з допомогою морфометричних параметрів продемонстровано динаміку таких змін. Дистрофічно-набрякові процеси у складових шкіри супроводжуються метаболічними порушеннями. Знижені показники обʼємної щільності колагенових та еластичних волокон відбувається паралельно із зростанням вмісту оксипроліну та еластази, відповідно. Таким чином, в умовах гіпотиреозу структурно-метаболічні порушення відбуваються у шкірі тварин обидвох вікових груп та обидвох досліджених локалізацій. Тиреоїдний статус, вміст холестерину на етапах вивчення підтверджують стан гіпотиреозу.
Women’s role in supporting the sustainability of smallholder coffee plantations in North Sumatra, Indonesia
Authors:   Department of Agriculture, Universitas Medan Area, Medan, Indonesia, Martial Tri , Lubis Yusniar ,   Department of Agriculture, Universitas Medan Area, Medan, Indonesia, Hernosa Siswa Panjang ,   Department of Agriculture, Universitas Medan Area, Medan, Indonesia, Harahap Ahmad Rizki ,   Department of Economic, Universitas Deli Sumatra, Medan, Indonesia, Jaya Mulia ,   Department of Social and Politics, Universitas Muara Bungo, Jambi, Indonesia, Tirtana Muhammad Arief ,   Department of Economic, Universitas Sumatra Utara, Medan, Indonesia, Nasution Fahman Urdawi ,   Department of Law, Universitas Deli Sumatra, Medan, Indonesia
Published: January 2025

This study examines the role of women in managing coffee plantations in traditional North Sumatra communities and its impact on household income, amidst restrictions imposed by the Dalihan Natolu system, a patrilineal tradition limiting their land rights and decision-making power. Using descriptive quantitative methods and Partial Least Squares Structural Equation Modeling (PLS-SEM), data were collected from six coffee-producing districts to analyze women’s rights to land, crops, and income. The findings reveal that women’s land tenure positively influences their rights to crops and income, emphasizing the need for secure land rights to enhance economic empowerment. Despite their significant contributions to coffee production, cultural norms marginalize women in land ownership, limiting their potential to improve household income. The study calls for institutional and policy reforms to address gender inequality, enhance women’s access to land and decision-making authority, and promote sustainable agricultural practices in smallholder coffee plantations, ultimately contributing to economic development and gender equity.
Principales tipos de podas en cultivos comerciales de mango Azúcar y Tommy Atkins
Authors: Pérez Artiles Lumey , De la Asunción Castro Fabio Javier , Yacomelo Hernández Marlon José , León Pacheco Rommel Igor , Parra Fuentes Madeleyne , Gómez Correa Juan Camilo
Published: January 2025

La poda es una práctica de manejo del cultivo que ayuda a regular el crecimiento y los hábitos reproductivos e influye de manera favorable en los procesos fotosintéticos, fitosanitarios, de fructificación y rendimiento de los árboles de especies frutales. En el árbol de mango mediante la poda se inducen flujos de crecimiento uniformes y la productividad puede incrementarse mediante la manipulación de las características de crecimiento fisiológico del cultivo.
Bridging Needs and Expectations of Individuals With Physical Disabilities and Community Services Stakeholders for the Cocreation of an Adapted Physical Activity Platform in Virtual Reality: Qualitative Study
Authors: Ramos Aurélien , Boisvert Maxence , Traverse Elodie , Levac Danielle , Lemay Martin , Demers Marika , Bordeleau Martine , Ruest Sarah-Maude , Périnet-Lacroix Roxanne , Best Krista L , Robert Maxime T
Published: January 2025

Background

Physical activity supports the health and well-being of individuals with physical disabilities. Despite the significance of engaging in physical activity, barriers faced by individuals with disabilities, such as limited access to adapted facilities and lack of transportation, can restrict their participation. Community organizations play a role in addressing these challenges, but virtual reality (VR) also offers a way to diversify adapted activities. In some situations, VR can help overcome the resource limitations of organizations by providing accessible, engaging, and highly personalized options for physical activity.

Objective

The aim of this study was to explore the needs and expectations of individuals with physical disabilities and their interventionists for the use of a VR physical activity platform in a community organization.

Methods

A descriptive qualitative study was conducted using semistructured interviews with individuals with physical disabilities and their interventionists, all associated with a nonprofit organization promoting physical activity among people with disabilities. Data were analyzed using an inductive thematic approach.

Results

In total, 15 participants, including 8 people with physical disabilities and 7 interventionists, were interviewed. Through this discussion, we gained insights into the everyday challenges faced by individuals with disabilities and identified priorities for community organizations. Subsequently, we discussed key considerations for using VR, including adapting activities, the possibility of fostering a more positive perception of physical activity, and harnessing the potential of VR to improve access to physical activity. We also discussed the importance of supporting personal goals and creating inclusive experiences while recognizing challenges such as technical difficulties and connectivity issues.

Conclusions

By exploring the needs and expectations regarding VR technology from individuals with physical disabilities and their interventionists, this study provided essential insights for integrating immersive and nonimmersive VR into community organizations, informing next steps for the design of adapted physical activities in VR.
Development of an eHealth Intervention Including Self-Management for Reducing Sedentary Time in the Transition to Retirement: Participatory Design Study
Authors: Hultman Lisa , Eklund Caroline , von Heideken Wågert Petra , Söderlund Anne , Lindén Maria , Elfström Magnus L
Published: January 2025

Background

Having a great amount of sedentary time is common among older adults and increases with age. There is a strong need for tools to reduce sedentary time and promote adherence to reduced sedentary time, for which eHealth interventions have the potential to be useful. Interventions for reducing sedentary time in older adults have been found to be more effective when elements of self-management are included. When creating new eHealth interventions, accessibility and effectiveness can be increased by including end users as co-designers in the development process.

Objective

The aim was to explore the desired features of an eHealth intervention including self-management for reducing sedentary time and promoting adherence to reduced sedentary time in older adults transitioning from working life to retirement. Further, the aim was to develop a digital prototype of such an eHealth intervention.

Methods

The study used the participatory design approach to include end users, researchers, and a web designer as equal partners. Three workshops were conducted with 6 older adults transitioning to retirement, 2 researchers, and 1 web designer. Thematic analysis was used to analyze the data from the workshops.

Results

Participants expressed a desire for an easy-to-use eHealth intervention, which could be accessed from mobile phones, tablets, and computers, and could be individualized to the user. The most important features for reducing sedentary time were those involving finding joyful activities, setting goals, and getting information regarding reduced sedentary time. Participants expressed that the eHealth intervention would need to first provide the user with knowledge regarding sedentary time, then offer features for measuring sedentary time and for setting goals, and lastly provide support in finding joyful activities to perform in order to avoid being sedentary. According to the participants, an eHealth intervention including self-management for reducing sedentary time in older adults in the transition to retirement should be concise, accessible, and enjoyable. A digital prototype of such an eHealth intervention was developed.

Conclusions

The developed eHealth intervention including self-management for reducing sedentary time in older adults transitioning to retirement is intended to facilitate behavior change by encouraging the user to participate in autonomously motivated activities. It uses several behavior change techniques, such as goal setting and action planning through mental contrasting and implementation intention, as well as shaping knowledge. Its active components for reducing sedentary time can be explained using the integrated behavior change model. Further research is needed to evaluate the feasibility and effectiveness of the eHealth intervention.
Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthesis
Authors: Eisner Emily , Faulkner Sophie , Allan Stephanie , Ball Hannah , Di Basilio Daniela , Nicholas Jennifer , Priyam Aansha , Wilson Paul , Zhang Xiaolong , Bucci Sandra
Published: January 2025

Background

Digital mental health interventions (DMHIs) to monitor and improve the health of people with psychosis or bipolar disorder show promise; however, user engagement is variable, and integrated clinical use is low.

Objective

This prospectively registered systematic review examined barriers and facilitators of clinician and patient engagement with DMHIs, to inform implementation within real-world settings.

Methods

A systematic search of 7 databases identified empirical studies reporting qualitative or quantitative data about factors affecting staff or patient engagement with DMHIs aiming to monitor or improve the mental or physical health of people with psychosis or bipolar disorder. The Consolidated Framework for Implementation Research was used to synthesize data on barriers and facilitators, following a best-fit framework synthesis approach.

Results

The review included 175 papers (150 studies; 11,446 participants) describing randomized controlled trials; surveys; qualitative interviews; and usability, cohort, and case studies. Samples included people with schizophrenia spectrum psychosis (98/150, 65.3% of studies), bipolar disorder (62/150, 41.3% of studies), and clinicians (26/150, 17.3% of studies). Key facilitators were a strong recognition of DMHIs’ relative advantages, a clear link between intervention focus and specific patient needs, a simple, low-effort digital interface, human-supported delivery, and device provision where needed. Although staff thought patients would lose, damage, or sell devices, reviewed studies found only 11% device loss. Barriers included intervention complexity, perceived risks, user motivation, discomfort with self-reflection, digital poverty, symptoms of psychosis, poor compatibility with existing clinical workflows, staff and patient fears that DMHIs would replace traditional face-to-face care, infrastructure limitations, and limited financial support for delivery.

Conclusions

Identified barriers and facilitators highlight key considerations for DMHI development and implementation. As to broader implications, sustainable business models are needed to ensure that evidence-based DMHIs are maintained and deployed.

Trial Registration

PROSPERO CRD42021282871; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=282871
Japan's Telepsychiatry Dissemination: Current Status and Challenges (Preprint)
Authors: Kinoshita Shotaro , Kishimoto Taishiro
Published: January 2025

UNSTRUCTURED

NA
Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study (Preprint)
Authors: Inayama Yoshihide , Yamaguchi Ken , Mizuno Kayoko , Tanaka-Mizuno Sachiko , Koike Ayami , Higashiyama Nozomi , Taki Mana , Yamanoi Koji , Murakami Ryusuke , Hamanishi Junzo , Yoshida Satomi , Mandai Masaki , Kawakami Koji
Published: January 2025

BACKGROUND

Although physical activity (PA) is recommended for patients with cancer, changes in PA across cancer diagnosis and treatment have not been objectively evaluated.

OBJECTIVE

This study aimed to assess the impact of cancer diagnosis and treatment on PA levels.

METHODS

This was a retrospective cohort study using a Japanese claims database provided by DeSC Healthcare Inc, in which daily step count data, derived from smartphone pedometers, are linked to the claims data. In this study, we included patients newly diagnosed with cancer, along with those newly diagnosed with diabetes mellitus for reference. We collected data between April 2014 and September 2021 and analyzed them. The observation period spanned from 6 months before diagnosis to 12 months after diagnosis. We applied a generalized additive mixed model with a cubic spline to describe changes in step counts before and after diagnosis.

RESULTS

We analyzed the step count data of 326 patients with malignant solid tumors and 1388 patients with diabetes. Patients with cancer exhibited a 9.6% (95% CI 7.1%-12.1%; P<.001) reduction in step counts from baseline at the start of the diagnosis month, which further deepened to 12.4% (95% CI 9.5%-15.2%; P<.001) at 3 months and persisted at 7.1% (95% CI 4.2%-10.0%; P<.001) at 12 months, all relative to baseline. Conversely, in patients with diabetes, step counts remained relatively stable after diagnosis, with a slight upward trend, resulting in a change of +0.6% (95% CI –0.6% to 1.9%; P=.31) from baseline at 3 months after diagnosis. At 12 months after diagnosis, step counts remained decreased in the nonendoscopic subdiaphragmatic surgery group, with an 18.0% (95% CI 9.1%-26.2%; P<.001) reduction, whereas step counts returned to baseline in the laparoscopic surgery group (+0.3%, 95% CI –6.3% to 7.5%; P=.93).

CONCLUSIONS

The analysis of objective pre- and postdiagnostic step count data provided fundamental information crucial for understanding changes in PA among patients with cancer. While cancer diagnosis and treatment reduced PA, the decline may have already started before diagnosis. The study findings may help tailor exercise recommendations based on lifelog data for patients with cancer in the future.
Development of an eHealth Intervention Including Self-Management for Reducing Sedentary Time in the Transition to Retirement: Participatory Design Study (Preprint)
Authors: Hultman Lisa , Eklund Caroline , von Heideken Wågert Petra , Söderlund Anne , Lindén Maria , Elfström Magnus L
Published: January 2025

BACKGROUND

Having a great amount of sedentary time is common among older adults and increases with age. There is a strong need for tools to reduce sedentary time and promote adherence to reduced sedentary time, for which eHealth interventions have the potential to be useful. Interventions for reducing sedentary time in older adults have been found to be more effective when elements of self-management are included. When creating new eHealth interventions, accessibility and effectiveness can be increased by including end users as co-designers in the development process.

OBJECTIVE

The aim was to explore the desired features of an eHealth intervention including self-management for reducing sedentary time and promoting adherence to reduced sedentary time in older adults transitioning from working life to retirement. Further, the aim was to develop a digital prototype of such an eHealth intervention.

METHODS

The study used the participatory design approach to include end users, researchers, and a web designer as equal partners. Three workshops were conducted with 6 older adults transitioning to retirement, 2 researchers, and 1 web designer. Thematic analysis was used to analyze the data from the workshops.

RESULTS

Participants expressed a desire for an easy-to-use eHealth intervention, which could be accessed from mobile phones, tablets, and computers, and could be individualized to the user. The most important features for reducing sedentary time were those involving finding joyful activities, setting goals, and getting information regarding reduced sedentary time. Participants expressed that the eHealth intervention would need to first provide the user with knowledge regarding sedentary time, then offer features for measuring sedentary time and for setting goals, and lastly provide support in finding joyful activities to perform in order to avoid being sedentary. According to the participants, an eHealth intervention including self-management for reducing sedentary time in older adults in the transition to retirement should be concise, accessible, and enjoyable. A digital prototype of such an eHealth intervention was developed.

CONCLUSIONS

The developed eHealth intervention including self-management for reducing sedentary time in older adults transitioning to retirement is intended to facilitate behavior change by encouraging the user to participate in autonomously motivated activities. It uses several behavior change techniques, such as goal setting and action planning through mental contrasting and implementation intention, as well as shaping knowledge. Its active components for reducing sedentary time can be explained using the integrated behavior change model. Further research is needed to evaluate the feasibility and effectiveness of the eHealth intervention.
Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthesis (Preprint)
Authors: Eisner Emily , Faulkner Sophie , Allan Stephanie , Ball Hannah , Di Basilio Daniela , Nicholas Jennifer , Priyam Aansha , Wilson Paul , Zhang Xiaolong , Bucci Sandra
Published: January 2025

BACKGROUND

Digital mental health interventions (DMHIs) to monitor and improve the health of people with psychosis or bipolar disorder show promise; however, user engagement is variable, and integrated clinical use is low.

OBJECTIVE

This prospectively registered systematic review examined barriers and facilitators of clinician and patient engagement with DMHIs, to inform implementation within real-world settings.

METHODS

A systematic search of 7 databases identified empirical studies reporting qualitative or quantitative data about factors affecting staff or patient engagement with DMHIs aiming to monitor or improve the mental or physical health of people with psychosis or bipolar disorder. The Consolidated Framework for Implementation Research was used to synthesize data on barriers and facilitators, following a best-fit framework synthesis approach.

RESULTS

The review included 175 papers (150 studies; 11,446 participants) describing randomized controlled trials; surveys; qualitative interviews; and usability, cohort, and case studies. Samples included people with schizophrenia spectrum psychosis (98/150, 65.3% of studies), bipolar disorder (62/150, 41.3% of studies), and clinicians (26/150, 17.3% of studies). Key facilitators were a strong recognition of DMHIs’ relative advantages, a clear link between intervention focus and specific patient needs, a simple, low-effort digital interface, human-supported delivery, and device provision where needed. Although staff thought patients would lose, damage, or sell devices, reviewed studies found only 11% device loss. Barriers included intervention complexity, perceived risks, user motivation, discomfort with self-reflection, digital poverty, symptoms of psychosis, poor compatibility with existing clinical workflows, staff and patient fears that DMHIs would replace traditional face-to-face care, infrastructure limitations, and limited financial support for delivery.

CONCLUSIONS

Identified barriers and facilitators highlight key considerations for DMHI development and implementation. As to broader implications, sustainable business models are needed to ensure that evidence-based DMHIs are maintained and deployed.

CLINICALTRIAL

PROSPERO CRD42021282871; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=282871