bluuebunny/crossref_metadata_2025 huggingface dataset:
A case of a small supernumerary ring chromosome r(20)(p12q12) in a 3-year-old boy with facial anomalies and speech delay
Authors: Антоненко В.Г. , Светличная Д.В. , Миньженкова М.Е. , Шилова Н.В. , Калиненкова С.Г.
Published: February 2021

Представлен случай малой сверхчисленной маркерной хромосомы (мСМХ) у мальчика трех лет с лицевыми аномалиями и речевыми нарушениями. Структура маркерной хромосомы, установленная при FISH-анализе, была определена как r(20)(p12q12). Обсуждаются проблемы мСМХ, содержащих только околоцентромерные области, и вопросы корреляции генотип-фенотип.

We report on a case of small supernumerary marker chromosome (sSMC) in a 3-year boy with facial anomalies and speech delay. The constitution of marker chromosome was designated by mFISH analysis as r(20)(p12q12). The problems of diagnostics of sSMC, containing the pericentromeric regions only, and genotype-phenotype correlations are discussied.
MicroRNA hsa-miR-370-3p is a new biomarker for assessing the level of CYP2D6 gene expression, as well as the clinical efficacy and safety of mirtazapine in patients with depressive disorders comorbid with alcohol use disorder
Authors: Застрожин М.С. , Скрябин В.Ю. , Гришина Е.А. , Рыжикова К.А. , Буре И.В. , Иванов А.В. , Копоров С.Г. , Брюн Е.А. , Сычев Д.А.
Published: February 2021

Проведено изучение влияния полиморфизма гена CYP2D6 на эффективность и безопасность терапии миртазапина у пациентов с депрессивными расстройствами, коморбидными с алкоголизмом. В группе из 106 пациентов с депрессивными расстройствами, коморбидными с алкогольной зависимостью, было продемонстрировано влияние полиморфизма 1846G>A гена CYP2D6 (rs3892097) на показатели профиля безопасности миртазапина, но не эффективности. При этом hsa-miR-370-3p остается перспективным биомаркером оценки уровня экспресии гена CYP2D6, так как уровень его плазменной концентрации отличался у носителей разных генотипов по полиморфному маркеру 1846G>A, хотя и не обнаружилась связь с клинической эффективностью и безопасностью.

The study of the effect of CYP2D6 gene polymorphism on the efficacy and safety of mirtazapine therapy in patients with depressive disorders comorbid with alcoholism was carried out. In a group of 106 patients with depressive disorders comorbid with alcohol dependence, the effect of the 1846G> A polymorphism of the CYP2D6 gene (rs3892097) on the safety profile of mirtazapine was demonstrated, but not on the effectiveness. At the same time, hsa-miR-370-3p remains a promising biomarker for assessing the level of CYP2D6 gene expression, since the level of its plasma concentration differed in carriers of different genotypes for the polymorphic marker 1846G> A, although no connection with clinical efficacy and safety was found.
Biosociality and bioidentity: current situation and ethical perspectives
Authors: Белялетдинов Р.Р. , Попов В.В. , Попова О.В.
Published: February 2021

Развитие генетических технологий способствовало стремительной биосоциализации современного общества. Биосоциальность и биоидентичность - феномены, описывающие важнейшие глобальные и локальные процессы развития современной биомедицины, определяющие интересы все большего числа людей. Создание групп по биосоциальным признакам невозможно без принципа конвергенции усилий. Он работает на разных уровнях общественной жизни, оказывая влияние и на формирование научного знания. Телесность пациента может рассматриваться в качестве гибридной формы, где сплетается органика, знание, технологии и экзистенциальный опыт персональной истории болезни. Возможности легитимации в будущем генетических технологий улучшения человека закладывают основание для формирования новых локусов биосоциальности и биоидентичности.

The development of genetic technologies has contributed to the rapid biosocialization of modern society. Biosociality and bioidentity are phenomena that describe the most important global and local processes of development of modern biomedicine, which determine the interests of an increasing number of people. Creating groups on biosocial grounds is impossible without the principle of convergence of efforts. It works at different levels of social life, influencing the formation of scientific knowledge. The physicality of the patient can be considered as a hybrid form where organics, knowledge, technology and existential experience of a personal medical history are intertwined. The possibilities of legitimizing the future genetic technologies for human enhancement lay the foundation for the formation of new loci of biosociality and bioidentity.
Evaluation of public opinion on moral status of human embryo
Authors: Хаят С.Ш. , Курило Л.Ф. , Черных В.Б.
Published: February 2021

Вопрос о правовом статусе эмбриона человека относится к ключевым проблемам современного национального, внутреннего и международного законодательства. В данной работе представлены результаты исследования общественного мнения о вопросе этико-правового статуса эмбриона человека методом анонимного анкетирования.

The moral status of human embryo is one of the key issues of modern national and international law. The study shows public opinion on the ethical and legal status of a human embryo according to the results of anonymous survey.
Influence of folatic cycle genes polymorphisms on lipid peroxidation parameters
Authors: Толочко Т.А. , Минина В.И. , Астафьева Е.А.
Published: February 2021

Длительное воздействие повышенных доз излучения от радона провоцирует накопление ацилгидроперекисей в крови подростков. Установлено наличие ассоциаций полиморфизмов генов фолатного цикла с показателями интенсивности перекисного окисления липидов.

Prolonged exposure to increased of radon doses provokes the accumulation of acyl hydroperoxis in the adolescents blood. The folate cycle gene polymorphism associations with lipid peroxidation intensity have been established.
Significance of polymorphic variants of the renin-angiotensin system, pro-oxidant-antioxidant system and vascular endothelial growth factor as genetic predictors of preeclampsia
Authors: Акуленко Л.В. , Сакварелидзе Н.Ю. , Цахилова С.Г.
Published: February 2021

В поиске генетических факторов риска развития преэклампсии изучалась роль полиморфных вариантов ключевых генов ренин-ангиотензиновой системы, прооксидантно-антиоксидантной системы и фактора роста эндотелия сосудов, возможно, формирующих ее основные клинические проявления: повышение артериального давления, оксидативный стресс плаценты и эндотелиальную дисфункцию сосудов в системе кровообращения «мать-плацента-плод». Определены достоверные генетические предикторы этого осложнения беременности.

In the search for genetic risk factors for preeclampsia, the role of polymorphic variants of key genes of the renin-angiotensin system, pro-oxidant-antioxidant system, and vascular endothelial growth factor was studied, possibly forming its main clinical manifestations: increased blood pressure, placental oxidative stress, and endothelial vascular dysfunction in the «mother-placenta-fetus» circulatory system. Reliable genetic predictors of this pregnancy complication have been determined.
Molecular mechanisms of imprinted gene disturbance in the embryonic development pathology and recurrent pregnancy loss
Authors: Саженова Е.А. , Лебедев И.Н.
Published: February 2021

Установлено, что остановка эмбрионального развития человека сопровождается мультилокусными дефектами метилирования импринтированных генов, частота которых повышена в плацентарных тканях спонтанных абортусов от женщин с привычным невынашиванием беременности. Показано, что множественные дефекты метилирования импринтированных генов сопровождаются мутациями гена NLRP7 у спонтанных абортусов от женщин с привычным невынашиванием беременности, а родители являются гетерозиготными носителями данных мутаций.

It was found that disturbances of embryonic development are accompanied by multi-locus imprinting disturbance (MLID), the frequency of which is increased in placental tissues of spontaneous abortions from women with recurrent pregnancy loss. It is shown that MLID are accompanied by NLRP7 gene mutations in spontaneous abortions from women with recurrent pregnancy loss, and parents are heterozygous carriers of these mutations.
Epigenetic modifications of the X chromosome in families with miscarriage
Authors: Толмачева Е.Н. , Саженова Е.А. , Никитина Т.В. , Фонова Е.А. , Лопаткина М.Е. , Затула Л.А. , Лебедев И.Н.
Published: February 2021

Асимметричная инактивация Х-хромосомы характерна как для женщин с привычным невынашиванием, так и для спонтанных абортусов с кариотипом 46,XX, а смещение инактивации у спонтанного абортуса чаще связано с наличием асимметричной инактивации у матери.

Skewed inactivation of the X chromosome is characteristic for women with recurrent pregnancy loss and spontaneous abortions with a karyotype 46,XX. Skewed X-inactivation in spontaneous abortion is more often associated with the asymmetric inactivation in the mother.
Genetic aspects of the idiopathic form of habitual miscarriage
Authors: Святова Г.С. , Березина Г.М. , Муртазалиева А.В.
Published: February 2021

Проведенное исследование позволило определить этиологическую обусловленность идиопатических форм привычного невынашивания беременности нарушениями иммунного взаимодействия материнских клеток с синцитиотрофобластом, а также носительством неблагоприятных аллелей риска главного комплекса гистосовместимости HLA 2 класса.

The first time made conducted study to determine the possible etiological condition of idiopathic forms of recurrent miscarriage by impaired immune interaction of maternal cells with syncytiotrophoblast, as well as by carriage of adverse risk alleles of the main HLA histocompatibility complex class 2.
Quantitative polymorphism of tandem repeats as a method of epigenetic regulation of the of human cells response to oxidative stress
Authors: Вейко Н.Н. , Ершова Е.С. , Конькова М.С. , Малиновская Е.М. , Костюк С.В.
Published: February 2021

Пространственная организация хроматина важна для нормального функционирования клетки. На архитектуру ядра влияют размеры отдельных фрагментов генома, которые коррелируют с числом копий этих фрагментов. Перемещение локусов 1q12 от поверхности ядра в центральные области является ключевой стадией адаптивного ответа клетки на стресс. Мы предположили, что размер локусов 1q12, который коррелирует с содержанием повтора f-SatIII, может влиять на перемещение этих участков хроматина в ядре. Методом FISH на выделенных лимфоцитах показали, что в контроле локусы 1q12 расположены вблизи поверхности ядра, в ядрах лимфоцитов больных шизофренией (БШ) и облученных контрольных клеток локусы 1q12 расположены в центральных районах ядра. Длительное культивирование облученных лимфоцитов сопровождалось гибелью клеток, и снижением содержания f-SatIII в ДНК. Очевидно, что погибали клетки с большим размером 1q12 (много f-SatIII), обогащая популяцию клетками с низким содержанием f-SatIII. В клетках БШ и в облученных клетках мы обнаружили повышение уровня РНК SATIII. Размеры гетерохроматина 1q12 в клетках человека могут влиять на процессы пролиферации и ответа клетки на стресс. Количественный полиморфизм тандемных повторов генома - один из эпигенетических механизмов регуляции ответа клеток на окислительный стресс.

The spatial organization of chromatin is important for the normal functioning of the cell. Genome repeat cluster sizes can affect the chromatin spatial configuration and function. The 1q12 heterochromatin loci movement from the periphery to the center of the nucleus is the cells’ universal response to various types of stress. We hypothesized that a large 1q12 domain could affect chromatin movement, thereby inhibiting adaptive response (AR). Using the FISH method, we shown that in the control, 1q12 loci are located near the surface of the nucleus; in the lymphocyte nuclei of schizophrenic patients and irradiated control cells, 1q12 loci are located in the central regions of the nucleus. During prolonged cultivation, the irradiated cells with a large Large f-SatIII amount die and the population is enriched with the cells with low f-SatIII content. In intact SZ patients’ lymphocytes and in irradiated cells we found an increase in SATIII RNA levels. The size of heterochromatin 1q12 loci in human cells can affect to the proliferation and cells’ adaptive response to stress. Quantitative polymorphism of tandem genome repeats is one of the epigenetic mechanisms of genome expression’s regulation.
Various combinations of genetic factors in men with infertility and their effect on fertility
Authors: Сафина Н.Ю. , Яманди Т.А. , Черных В.Б. , Акуленко Л.В.
Published: February 2021

Генетические причины снижения фертильности у мужчин представлены изменениями генома как отдельными, так и сочетанными. Целью исследования явилось изучение частоты встречаемости генетических факторов, влияющих на репродукцию, их сочетания и фенотипических проявлениий.

Genetic causes of decreased fertility in men are represented by changes in the genome both separate and combined. The aim of the study was to study the frequency of occurrence of genetic factors leading to impaired reproduction, their combination and phenotypic manifestations.
Peningkatan Pemahaman Siswa Dalam Menentukan Luas Bangun Ruang Melalui Metode Driil Pada Siswa Kelas VI SDN 15 Laman Bukit
Authors: Asira Asira
Published: February 2021

The general purpose of this study was to determine the ability and understanding to determine the area of building in class VI students at SDN 15 Laman Bukit in the subject of mathematics. Specifically, it is to describe 1) improvement of students 'understanding in determining the area of building in class VI students of SDN 15 Laman Bukit, 2) Describe the extent of the drill method to increase students' understanding in determining the area of building in grade VI students of SDN 15 Laman Bukit. The method used is Classroom Action Research and researchers as action actors. The subjects of this study were the sixth grade students of SDN 15 Laman Bukit in the academic year of 2019/2020 as many as 16 students consisting of 8 male students and 8 female students and mathematics class VI teachers who were also as researchers. The procedure of conducting Indonesian Language learning research uses audio visual media through four stages, namely: a) planning, b) implementation, c) reflection and d) evaluation. Data collection techniques in research are non-test techniques in the form of cycles, questionnaires, and documentation. The cycle is done individually or in groups to find out and observe the development of students' mathematical abilities in the learning process which includes aspects of communication, cooperation, confidence, and empathy in conducting activities in the process of learning mathematics. The instrument used during the observation was a cycle worksheet. The score given on the cycle sheet uses a scale of 1 - 5. The results showed an increase in students' mathematical ability in groups in the process of learning mathematics increased from 19% in the initial conditions to 30% in cycle I and increased to 40% in Cycle II from the good category in cycle II increased to very good in cycle III.
Pelaksanaan Kebijajakan Akreditasi Sekolah Pada Sekolah Menengah Umum (SMU) Negeri I Toho Kecamatan Toho Kabupaten Mempawah
Authors: Sikwan Agus , Y D Anggreini
Published: February 2021

This study is entitled: "Implementation of the School Accreditation Policy in the Public High School (SMU) I Toho, Toho District, Mempawah Regency". Using qualitative analysis, the results of this study indicate that the  mplementation of the school accreditation system policy implemented by the West Kalimantan Province School Accreditation Board (BAS) towards the Toho I State High School since 2005 has been going well, and has had a positive impact on the average increase passing grade results of the Final School Examination (UAS) obtained by students majoring in Social Sciences and Natural Sciences at Toho I State High School in 2017 to 2018 when compared with the average value of UAS results obtained by Toho I State High School students in 2014, despite the increase in grades the average UAS results obtained by the students were still unsatisfactory for students' parents and the school. The results also showed that the performance of the school principal as the bureaucratic apparatus of the Toho State High School I in providing administrative services to the school community was seen from the aspect of responsiveness which could be said to be good, because school residents felt there was a communication channel provided by the Toho District Education Office to convey their aspirations. In addition, the ability of the bureaucratic apparatus at the Toho District Education Office to recognize what the school community wants through direct interaction with them, causes the demands and desires of the school community to be poured by the Toho subdistrict Education Office in the form of a work program which then get a positive response from the principal of Toho I State High School to implement it.
NEW DIRECTIONS OF LABOR MIGRATION FROM TAJIKISTAN TO THE PERSIAN GULF COUNTRIES: DEVELOPMENT TRENDS AND PROSPECTS
Authors: Rakhmonov A. Kh.
Published: February 2021

Currently, labor migration from Central Asian countries is acquiring new geographical and socio-demographic dimensions, and migration flows are being reoriented to new directions and regions. The article considers the factors and scale of emigration from Tajikistan, the reasons for the reorientation of Tajik migrants from Russia to the Persian Gulf countries, as well as interstate agreements between Tajikistan and the Persian Gulf countries in the field of labor migration regulation. The author cites economic and geopolitical factors as the reasons for the changes: on the one hand, the fall in the ruble exchange rate and the decline in the level of wages in ruble terms, the tightening of migration policies in Russia and Kazakhstan force some migrant workers to look for new directions for migration; on the other hand, the participation of public and private labor agents is becoming more active.
FEATURES OF MONETARY POLICY OF FOREIGN DEVELOPED COUNTRIES DURING THE PANDEMIC
Authors: Gorbacheva T. A.
Published: February 2021

The subject of the study is the financial system and monetary regulation of the economy during the COVID-19 coronavirus pandemic. The purpose of the article is to investigate the monetary policy pursued by the national Central banks of developed countries in the context of the economic crisis caused by pandemic. The paper uses comparative analysis, a systematic approach to the study of information, as well as graphical and tabular methods. The author considers monetary policy instruments used by national Central banks of developed countries to mitigate the impact of the pandemic on the real sector of the economy. The study reveals distinctive features of anti-crisis measures of monetary regulation bodies.
ANALYSIS OF THE DEVELOPMENT OF VIRTUAL FAN COMMUNITIES MEDIA SPACES
Authors: Timokhovich A. N. , Nikuradze O. I.
Published: February 2021

The article deals with the development of media spaces of virtual fan communities. The aim of the research was to reveal the specifics of online communication of virtual fan communities with the audience. The paper investigates the dialectics of the concepts of fan-community, media space, fandom. The article considers the main approaches to studying media space by Russian and foreign authors. The study describes the traditional offline communication practices of the fandoms. The authors substantiate the problem of the existence of a variety of communication channels of the fan communities with the audience (negative interpretation of content, limitations in monetization and evaluation of the effectiveness of communication practices, the growth of costs for the diversification of content, taking into account the features of different platforms). The paper identifies the trend of centralization of fan communities and the possibilities of technological support of user experience at all stages of the communication process as part of the use of online platform. The article gives an analysis of the media environment and media spaces of South Korea’s fan communities on the example of the South Korean case of the development of the fandom media space in the format of the Weverse mobile application. The study considers the techniques of interaction with the audience in the offline interaction limitations. The authors formulate conclusions about the specifics of the extended functionality of the platform, about the provided ways of organizing the virtual fan media space with the help of the platform; about the coming trend of transferring fan activities into the virtual environment.
CONSISTENCY OF THE PROVISIONS ON THE ALL-RUSSIAN CIVIL IDENTITY CONTAINED IN THE DOCTRINAL DOCUMENTS ON THE STATE NATIONAL POLICY OF RUSSIA AND THE REPUBLICS-SUBJECTS OF THE FEDERATION
Authors: Yakhshiyan O. Yu.
Published: February 2021

The article contains a comparative analysis of doctrinal documents in the field of state national policy at the federal and regional-republican levels for consistency of provisions on the Russian nation and all-Russian civil identity. The paper considers in detail the interpretation of the relevant provisions in the Strategy of the State National Policy of the Russian Federation for the period up to 2025. The author draws on the publications of Russian ethnopolitologists, which study the practice of politicizing the titular ethnic identity in a number of republics of the Russian Federation with the prospect of identifying ethnic and regional identities. Reference to the corpus of concepts (strategies) of national policy in the republics – subjects of the Russian Federation allowed us to identify the accepted provisions on the all-Russian civil identity contained in the federal Strategy, and the republican-ethnic accents in its interpretation, and the provisions that have not yet been picked up. In particular, the analysis of doctrinal documents of the republics showed that one of the most important provisions of the Federal Strategy on Preservation of Russian Cultural Dominance (a Single Cultural-Civilizational Code), common to all the peoples of Russia, as the basis of all-Russian civil identity has not received a response in concepts (strategies) of the Russian republics.
PERSONAL ASPECT OF MEDICAL STUDENTS’ TRAINING BASED ON UNDERSTANDING OF PSYCHOLOGICAL DIFFICULTIES OF THE PROFESSION
Authors: Evdokimova E. G. , Kovalenko E. V.
Published: February 2021

The article investigates the issues of psychological difficulties prevention in the medical profession in the training of medical students. The paper substantiates the arguments for strengthening the personal aspect of medical students’ training based on understanding the ideas about difficulties in the work of a doctor. The authors reveal the interrelation between personal characteristics of students (conscientiousness, understanding of emotions, benevolence, etc.) and their ideas about the nature of difficulties in the chosen specialty at the stage of training. The study presents the main directions of students’ understanding of such difficulties. The article describes strategies for supporting students based on the correlations of personal characteristics and the above-mentioned ideas, aimed at mastering a confident behavior by students. The proposed strategies can be of interest to teachers of courses related to ethical issues of the profession, as well as in individual work with medical students.
KEY INFORMATION AND COMMUNICATION TECHNOLOGIES AS AN IMPORTANT FACTOR IN IMPROVING THE EFFICIENCY OF SUPPLY CHAINS IN THE FASHION INDUSTRY
Authors: Barkova N. Yu.
Published: February 2021

The article considers key information and communication technologies used in the supply chains of the fashion industry. The author segmented these technologies into several groups, including selected programs that ensure effective communication between the company’s functional departments and supply chain links; software resources aimed at maintaining logistics operations, such as production, warehousing, cargo transportation; operational and strategic planning systems. The main purpose of the considered information technologies is to take into account the specific characteristics of the “fashion” business, such as a high range and a short product life cycle, the need to take into account the rapidly changing requirements of buyers of goods in the fashion industry, the geographical distribution of supply chain participants. The author performs a review of key software products and technologies that improve the efficiency of business process management in the supply chains of the fashion industry, including CAD and CAM systems, ERP systems on the example of SAP AFS, SAP Fashion Management and some other software resources and technologies.
TRANSFORMATIONAL TRENDS AND INNOVATIVE FACTORS IN THE DEVELOPMENT OF THE WHOLESALE AND RETAIL SECTORS OF THE PHARMACEUTICAL MARKET
Authors: Bykova E. A.
Published: February 2021

The article discusses important features of trends in the transformation of the wholesale and retail level of the Russian medicinal market in the context of innovative factors in the development of the pharmaceutical industry in Russia. The paper gives a general assessment of the impact of state regulation of the maximum selling prices for medicines from the list of vital and essential medicines on the profitability of the market. The author presents a simplified institutional scheme of interaction between distributors and other market participants. The study discusses important aspects and tactical steps of the distribution and pharmacy level of the Russian pharmaceutical market. The article gives the ratings of the leading distribution pharmaceutical companies in Russia and analyses the peculiarities of their structural changes under the influence of innovative development factors. The paper gives ratings of leading pharmacy chains and analyses the features of new structural formations – associations. The author proposes the term of “polarization” for wholesale and retail companies.
FACTORS OF GROWTH OF THE EFFICIENCY OF PUBLIC DEBT MANAGEMENT
Authors: Kosov M. E.
Published: February 2021

Public debt is an integral part of public finances of various countries, the process of its management, including formation, maintenance and repayment has a powerful impact on the macroeconomic system of the state. The subject of the study is the public debt of the Russian Federation. The article performs a correlation and regression analysis of factors that have a direct impact on the state of the Russia’s public debt under the conditions of the restrictions caused by the Covid-19 coronavirus infection, as well as the consequences of these restrictions. The paper proposes an econometric model that describes a system of indirect macroeconomic factors that are not directly related to the state’s debt policy, but show the strongest influence on the formation of public debt in modern realities and increase the efficiency of its management, as well as reflect the quality of public financial management in general. The author concludes that the demographic burden and the indicator reflecting the ratio of the budget deficit to the total budget revenue have the greatest impact on the effectiveness of public debt management.
MANAGEMENT TECHNIQUES FOR REDUCING ADMINISTRATIVE BARRIERS WHEN PROVIDING STATE AND MUNICIPAL SERVICES IN THE RUSSIAN FEDERATION
Authors: Demin A. V. , Rybalchenko I. V. , Milkina I. V.
Published: February 2021

The subject of the study is administrative barriers in the provision of public services to individuals and business entities in the Russian Federation. The article proposes methods of analysis of the quality of providing public and municipal services to the population and economic entities. The paper investigates the degree of openness of public authorities. The authors propose a systematic approach to the study of the causes and conditions of administrative barriers, as well as an effective universal system of measures designed to eliminate such barriers and improve the quality of the state’s response to public requests. The paper studied methods of combating administrative barriers in a practical application with the establishment of the main techniques and methods of public administration, the methodology for eliminating administrative barriers. The authors analyze the role of self-regulation, professional communities and social networks in removing administrative barriers.
MEASURES TO REDUCE THE DEFECTIVENESS OF AVIATION PRODUCTS AND ASSESSMENT OF THE EFFECTIVENESS OF ITS IMPLEMENTATION
Authors: Orlova L. V. , Zobov P. V.
Published: February 2021

The article considers the problems of reducing the quality of aviation products, leading to the loss of competitiveness of finished products and an increase in cost price. In the course of the study, the authors analysed the reasons for the appearance of defective products at an aviation manufacturing enterprise. Based on the information received using modern data processing methods, the paper determines the main weaknesses of the considered technological stage of aviation products. Having studied modern international quality standards in the field of aviation construction, the authors proposed measures that would reduce the number of defective products and increase the reliability and competitiveness of finished products. The article presents separately the model for evaluating the effectiveness of measures to reduce the defectiveness of aviation products. The paper carries out assessment of the proposed tactical measures to reduce the level of defective products, which will increase the economic performance of production activities in certain areas of production.
ASSESSING THE EFFECTIVNESS OF GOVERNMENT PROGRAMS
Authors: Fedchenko E. A. , Buryakova A. O.
Published: February 2021

The article presents the results of the analysis of the approved by law methodology for assessing the effectiveness of the implementation of state programs of the Russian Federation. The paper ascertains that the methodology has a number of shortcomings in terms of calculating individual indicators, does not take into account the industry specifics of measures. In order to eliminate the shortcomings of the current methodological base, the authors proposed an adjusted methodology for assessing efficiency, which involves the use of mathematical modeling methods, qualitative assessment criteria, modified coefficients. At the same time, the weighting coefficients of the main criteria of the method were revised – the study proposes to use the method of Saati hierarchies. The developed proposals are aimed at improving the accuracy and reliability of the results of assessing the effectiveness of government programs.
Benzyl and Phenyl Glucosinolates Are Metabolized by the Specific Plant Pathogen Alternaria Brassicicola but Not by the Generalist Fungal Pathogens Rhizoctonia Solani or Sclerotinia Sclerotiorum
Authors: Pedras M. Soledade C. , Thapa Chintamani , Hossain Sajjad
Published: February 2021

The metabolism of benzyl and phenyl glucosinolates by three phytopathogenic fungal species is investigated and established that A. brassicicola metabolized intact benzyl and phenyl glucosinolates and the corresponding desulfo derivatives. Syntheses and spectroscopic characterization of benzyl and phenyl desulfo-glucosinolates are reported. Phenylacetonitrile and benzylisothiocyanate are the first metabolic products of benzyl glucosinolate; benzyl isothiocyanate is further metabolized to 3-benzyl-2-thioxo-2,3-dihydrothiazolidine-4-carboxylic acid.
Using the Mechanical Bond to Tune the Performance of a Thermally Activated Delayed Fluorescence Emitter
Authors: Rajamalli P , Rizzi Federica , Li Wenbo , Jinks Michael , Gupta Abhishek , Laidlaw Beth , Samuel Ifor , Penfold Thomas , Goldup Stephen , Zysman-Colman Eli
Published: February 2021

We report the characterization of rotaxanes based on a carbazole–benzophenone thermally activated delayed fluorescence luminophore. We find that the mechanical bond leads to an improvement in key photophysical properties of the emitter, notably an increase in photoluminescence quantum yield and a decrease in the energy difference between singlet and triplet states, as well as fine tuning of the emission wavelength, a feat that is difficult to achieve when using covalently bound substituents. Computational simulations, supported by X-ray crystallography, suggest that this tuning of properties occurs due to weak interactions between the axle and the macrocycle that are enforced by the mechanical bond. This work highlights the benefits of using the mechanical bond to refine existing luminophores, providing a new avenue for emitter optimization that can ultimately increase the performance of these molecules.
Non-Woven Materials for Cloth-Based Face Mask Inserts: Relationship Between Material Properties and Sub-Micron Aerosol Filtration
Authors: Crilley Leigh R. , Angelucci Andrea , Malile Brian , Young Cora J. , VandenBoer Trevor C. , Chen Jennifer
Published: February 2021

Current guidance by leading public health agencies recommends wearing a 3-layer cloth-based face mask with a middle non-woven material insert to reduce the transmission of infectious respiratory viruses like SARS-CoV-2. In this work we explore the material characteristics for a range of readily available non-woven materials and their sub-micron particle filtration efficiency (PFE), with the aim of providing evidence-based guidelines for selecting appropriate materials as inserts in cloth-based masks. We observed a wide range of ideal PFE for the tested non-woven materials, with polypropylene, Swiffer and Rayon/polyester blend providing the highest PFE and breathability. Our results suggest that materials comprising loose 3D fibrous webs (e.g. flannel, Swiffer and gauze) exhibited enhanced filtration efficiency compared to compressed counterparts. Common modifications to fabrics, such as water-resistant treatment and a sewn seam were also investigated. Overall, we demonstrate that adding an appropriate non-woven material as an insert filter can significantly improve the performance of cloth-based masks, and there exist suitable cellulose-based alternatives to polypropylene.
Preparation of 2-((4-Methylpentan-2-Yl)amino)-5-(Phenylamino)cyclohexa-2,5-Diene-1,4-Dione (6PPD-Quinone), an Environmental Hazard for Salmon
Authors: Agua Alon , Stanton Ryan , Pirrung Michael
Published: February 2021

A recent report has identified 6PPD-quinone as an environmental compound responsible for drastic declines in coho salmon (Oncorhynchus kisutch) populations. As it is derived by oxidation of the preservative 6PPD that is found in tire rubber, this compound is not commercially available for further investigation of its biological properties. This work provides a brief synthesis of the oncorhynchicide 6PPD-quinone that can be used for that purpose.
Cycloparaphenylene-Phenalenyl Radical and Its Dimeric Double Nanohoop
Authors: Yang Yong , Blacque Olivier , Sato Sota , Juricek Michal
Published: February 2021

We report the first example of a neutral spin-delocalized carbon-nanoring radical, achieved by integration of an open-shell graphene fragment phenalenyl into cycloparaphenylene (CPP). We show that spin distribution in this hydrocarbon partially extends from the phenalenyl onto the CPP segment as an interplay of steric and electronic effects. The resulting geometry is reminiscent of a diamond ring, with pseudo-perpendicular arrangement of the radial and the planar π-surface. Remarkably, this geometry gives rise to a steric effect that governs a highly selective dimerization pathway, yielding a giant double nanohoop. Its π-framework made of 158 sp2-carbon atoms was unambiguously elucidated by single crystal X-ray diffraction, which revealed a three-segment CPP–peropyrene–CPP structure. This nanocarbon shows a fluorescence profile characteristic of peropyrene, regardless of which segment gets excited. These results in conjunction with DFT suggest that adjustment of the size of the CPP segments in this double nanohoop could deliver true donor–acceptor systems.
Diastereoselective Synthesis of b-Branched a-Amino Acids via Bio-catalytic Dynamic Kinetic Resolution
Authors: Li Fuzhuo , Yang Li-Cheng , Zhang Jingyang , Chen Jason , Renata Hans
Published: February 2021

We report a biocatalytic transamination method to prepare a broad range of b-branched a-amino acids that proceeds with high diastereo- and enantioselectivity. Mechanistic studies show that the transformation proceeds through a dynamic kinetic resolution process that is unique to the optimal enzyme. To highlight its utility and practicality, the biocatalytic reaction is applied to the synthesis of several cyclic fragments and in the first total synthesis of jomthonic acid A.
A New Azo Dye Based Sensor for Selective and Sensitive Detection of Cu(II), Sn(II), and Al(III) Ions
Authors: Kshtriya Vivekshinh , Koshti Bharti , Gour Nidhi
Published: February 2021

In this manuscript, we report for the very first time synthesis of a new purple azo dye (E)-1-((5-methoxy thiazolo[4,5-b]pyridin-2-yl) diazenyl) naphthalen-2-ol (TPN1). TPN1 also exhibits very interesting sensing behavior and can be potentially used for highly selective and sensitive detection of Cu2+, Sn2+ and Al3+. The changes in the absorption properties of TPN1 in the presence of various cations were studied extensively by UV visible spectroscopy. TPN1 dye which exhibits purple color changes to blue, orange, and lavender color respectively on addition of Cu2+, Sn2+, and Al3+ ions respectively. Notably, TPN1 reveal different color with the number of metal ions but the peak shifting could be observed only with three metal ions in solution. Addition of Cu2+ to TPN1 caused bathochromic shift, while in the case of Sn2+ and Al3+ a hypsochromic effect could be observed through UV-visible spectroscopy.
Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors
Authors: Quach David , Tang Guanghui , Anantharajan Jothi , Baburajendran Nithya , Poulsen Anders , Wee John , Retna Priya , Li Rong , Liu Boping , Tee Doris , Kwek Perlyn , Joy Joma , Yang Wan-Qi , Zhang Chong-Jing , Foo Klement , Keller Thomas , Yao Shao
Published: February 2021

Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent targeting of the catalytic lysine with improved single-digit nanomolar potency against both wild-type and mutant ABL kinases, especially ABLT315I bearing the gatekeeper residue mutation. We show that, by using techniques including mass spectrometry, time-dependent biochemical assays and X-ray crystallography, the evolutionarily conserved lysine can be targeted selectively. Furthermore, we show that the selectivity depends largely on molecular recognition of the non-covalent pharmacophore in this class of inhibitors, probably due to the moderate reactivity of the warhead. We report the first co-crystal structures of covalent inhibitor-ABL kinase domain complexes, providing insights into the interaction of this warhead with the catalytic lysine. We also employed label-free mass spectrometry to evaluate potential off-targets of our compounds at proteome-wide level in different cancer cell lines.
Synthesis and Characterization of Novel Ternary Hybrid Nanoparticles as Thermal Additives in H2O
Authors: Zayan Mohammed , Rasheed Abdul Khaliq , John Akbar , Muniandi Shalini , fen leo bay , Faris Ahmad
Published: February 2021

The performance of water as a heat transfer medium in numerous applications is limited by its effective thermal conductivity. In order to improve the thermal conductivity of water, herein we report the development and thermophysical characterization of a novel metal-metaloxide-carbon based ternary hybrid nanoparticles (THNp), GO-TiO2-Ag and the rGO-TiO2-Ag. The results indicate that the graphene oxide and reduced graphene oxide based ternary hybrid nanoparticles dispersed in water enhance its thermal conductivity by 66% and 83%, respectively, even at very low concentrations. Mechanisms contributing to this significant enhancement are discussed. The experimental thermal conductivity is plotted against the existing empirical hybrid thermal conductivity correlations. We found that those correlations are not suitable for the metal-metaloxide-carbon combinations, calling for the developing a new thermal conductivity models. The rheological measurements of the nanofluids display non-Newtonian behavior, and the viscosity reduces with the increase in temperature. Such behavior is possibly due to the non-uniform shapes of the ternary hybrid nanoparticles.
A Study On Assessment Of Autonomic Nervous System Function In Patients With Type 2 Diabetes Mellitus
Authors: Sharath shanmugam  , Oshin mantro  , Jagadeesan M  , Mariraj I  , Prasanna Karthik S  , Gowrishankar  , Magesh Kumar  , Vinoth Kanna S
Published: February 2021

The autonomic nervous system (ANS) innervates the entire neuraxis and influences the functions of all organs. This study was undertaken for evaluating the autonomic dysfunction in diabetic patients using clinical autonomic tests and neuro- electrophysiology. A prospective study was carried out in 66 patients with type II diabetes mellitus in a tertiary care hospital for one year. Systemic examination, necessary investigations, nerve conduction study and clinical testing for the autonomic nervous system were done. The results were noted and analyzed. 65.2% were females, whereas 34.8% were males. Mean duration of diabetes was found to be 9.06 years (SD 4.121). 80.3% population was known to have type 2 diabetes for 5-10 years duration, 13.6% had diabetes for 10-15 years, and only 3.5% had diabetes for more than 15 years. Mean FBS was found to be 196.12(mg/dl) ±77.180 SD and mean PPBS was 303.26(mg/dl) ± 115.385 SD. Mean HbA1c levels were 10.95 ± 2.36 SD. 33.3% showed early parasympathetic involvement for cardiac autonomic neuropathy, 9% had definite parasympathetic involvement, and only 6% had both parasympathetic and sympathetic involvement. 62.12% showed abnormal responses in nerve conduction study, of which 48.78% had autonomic dysfunction. The main factor responsible for the development and progression of autonomic dysfunction is poor glycaemic status. If contributing factors can be detected, early identification of cardiac autonomic neuropathy (CAN) and appropriate management would halt its progression. Aggressive glycaemic monitoring and treatment shall bring down the progression and prolong the time interval in showing abnormal responses in autonomic function testing.
Exploration of the Characteristics of Animal Supply and Demand in University Experimental Teaching Pratice
Authors: Cao Yongshi
Published: February 2021

The supply and demand of laboratory animals for teaching in colleges and universities has its own internal characteristics. To grasp the supply and demand characteristics of laboratory animals for teaching is of vital importance to the planning, supply and use of teaching animals, the realization of teaching objectives and the completion of teaching tasks. Based on the supply of teaching experimental animals and the work of animal experimental teaching in our university in recent years, this paper expounds the inherent characteristics and practice of supply and demand of teaching experimental animals.
Teaching Strategies of Chinese Works Course in Korean Education
Authors: Li Yinxing
Published: February 2021

In the stage of Korean teaching, the teaching of Korean literature can help students to deepen the memory effect of Korean, make students understand the rich types of Korean literature, and improve the quality and efficiency of teaching. In the research of this paper, we will analyze the role of innovative Chinese works course in Korean Education in detail, and finally put forward innovative teaching strategies to throw a brick to attract jade.
Analysis of Conflict Talks in Zootopia from the Perspective of Adaptation Theory
Authors: Li Yunli
Published: February 2021

Conflict talk is a common and complex linguistic phenomenon existing in life, mainly referring to verbal interaction events such as disputes, dissent, and refutation between the two parties in the conversation. This paper is based on Verschueren’s adaptation theory, combined with the representative conflict cases in the movie Zootopia, and the multi-angle analysis of the expression of dialogue conflicts. And it tries to find the specific causes of conflict talks, in order to provide methods to solve or alleviate the discourse conflicts in life.
Strategies on Promoting Transformative Learning of College English Teachers
Authors: Zhao Wenbo
Published: February 2021

Based on the previous case study in promoting transformative learning of college English teachers, who participated in a three-month online training courses, the article made a further research and concluded four strategies on promoting transformative learning of college English Teachers.
Based on the Construction of University Library and the Evaluation of Space Service Quality
Authors: Ying Wan
Published: February 2021

In order to strengthen the construction of university library, promote the sustainable development of university library, and provide a good library space environment for university students, this paper expounds the quality evaluation of university library by establishing the evaluation index of space service quality, and puts forward the ways to improve the service quality of University Library for reference.
A Study on Conceptual Metaphors in the Report on the Work of the Government (2020)
Authors: Luan Lan , Sun Weijie
Published: February 2021

The Report on the work of government (2020) is an annually political discourse, which provides a consistent topic to linguistic research. And conceptual metaphor provided by George Lakoff, is an important part of cognitive linguistics and a way of discourse analysis. From the perspective of conceptual metaphor, this study explores proportion and distribution of conceptual metaphor used in the discourse, and analyzes the function of major metaphors. It is proved that there are totally 12 categories of metaphors, which are made up of 8 major metaphor and 4 minor metaphor. The major metaphors function hierarchically and reflect effect of epidemic represented in the discourse. By analyzing the conceptual metaphor in the discourse, it is expected to shade a light on the understanding of metaphor illustration of the discourse.
Exploration on the Reform of Ideological and Political Teaching of Environmental Chemistry Course
Authors: Feng Dan , Qi Baochuan , Liu Yunqing , Wang Xinglei
Published: February 2021

To carry out curriculum ideological and political education is to thoroughly implement the whole staff, the whole process, and all-round education. Taking the environmental chemistry course as an example, it introduces the feasibility of developing ideological and political education, and analyzes how to realize the integration of environmental chemistry courses and ideological and political education from the aspects of changing concepts, carefully designing teaching content, and playing the role of training courses and experimental courses. Integration has achieved certain results, providing reference and reference for environmental majors to carry out related courses ideological and political education.