bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm
Authors: Tedjawirja V. N. , Mieremet A. , Rombouts K. B. , Yap C. , Neele A. E. , Northoff B. H. , Chen H. J. , Vos M. , Klaver D. , Yeung K. K. , Balm R. , de Waard V.
Published: May 2023

Introduction

Follicle stimulating hormone (FSH) is identified to play a role in postmenopausal disease and hypothesized to affect abdominal aortic aneurysm (AAA) onset/progression in postmenopausal women. We aimed to detect FSHR gene expression in AAA tissue and cell types involved in AAA formation.

Methods

FSH stimulation of human umbilical cord endothelial cells (HUVECs), smooth muscle cells (HUCs) and PMA-differentiated macrophages to assess gene expression of FSHR and various markers. Human macrophages activated with various stimuli were assessed for FSHR gene expression. AAA dataset, AAA tissue samples and AAA-derived smooth muscle cells (SMC) obtained from elderly female donors were assessed for FSHR gene expression. AAA-SMCs were stimulated with FSH to assess its effect on gene expression. Lastly, oxidized low-density-lipoprotein (ox-LDL) uptake and abundance of cell surface protein markers were assessed by flow cytometry after FSH stimulation of human monocytes.

Results

FSH stimulation showed similar levels of gene expression in HUVECs and HUCs. Only ACTA2 was downregulated in HUCs. In PMA-differentiated macrophages, gene expression of inflammation markers was unchanged after FSH stimulation. FSHR gene expression was found to be low in the AAA datasets. Female AAA-SMCs show occasional FSHR gene expression at a very low level, yet stimulation with FSH did not affect gene expression of SMC- or inflammation markers. FSH stimulation did not impact ox-LDL uptake or alter cell surface protein expression in monocytes. While FSHR gene expression was detected in human testis tissue, it was below quantification level in all other investigated cell types, even upon activation of macrophages with various stimuli.

Conclusion

Despite previous reports, we did not detect FSHR gene expression in various extragonadal cell types, except in occasional female AAA-SMCs. No clear effect on cell activation was observed upon FSH stimulation in any cell type. Our data suggest that a direct effect of FSH in AAA-related extragonadal cells is unlikely to influence AAA.
Temporal convolutional network for a Fast DNA mutation detection in breast cancer data
Authors: Wisesty Untari Novia , Mengko Tati Rajab , Purwarianti Ayu , Pancoro Adi
Published: May 2023

Early detection of breast cancer can be achieved through mutation detection in DNA sequences, which can be acquired through patient blood samples. Mutation detection can be performed using alignment and machine learning techniques. However, alignment techniques require reference sequences, and machine learning techniques still cannot predict index mutation and require supporting tools. Therefore, in this research, a Temporal Convolutional Network (TCN) model was proposed to detect the type and index mutation faster and without reference sequences and supporting tools. The architecture of the proposed TCN model is specifically designed for sequential labeling tasks on DNA sequence data. This allows for the detection of the mutation type of each nucleotide in the sequence, and if the nucleotide has a mutation, the index mutation can be obtained. The proposed model also uses 2-mers and 3-mers mapping techniques to improve detection performance. Based on the tests that have been carried out, the proposed TCN model can achieve the highest F1-score of 0.9443 for COSMIC dataset and 0.9629 for RSCM dataset, Additionally, the proposed TCN model can detect index mutation six times faster than BiLSTM model. Furthermore, the proposed model can detect type and index mutations based on the patient’s DNA sequence, without the need for reference sequences or other additional tools.
New insights into the recent collapse of Eastern Baltic cod from historical data on stock health
Authors: Eero Margit , Brander Keith , Baranova Tatjana , Krumme Uwe , Radtke Krzysztof , Behrens Jane W.
Published: May 2023

The Eastern Baltic cod (Gadus morhua) stock is currently in a very poor state, with low biomass and adverse trends in several life history and demographic parameters. This raises concern over whether and to what level recovery is possible. Here, we look for new insights from a historical perspective, extending the time series of various stock health indicators back to the 1940s, i.e. to the beginning of intensive exploitation of the Eastern Baltic cod. The historical data confirm that the stock deterioration in recent years is unprecedented, as all indicators are presently in their worst states on record. Cod body condition and energy reserves were equally low in the 1940s–1950s, accompanied by high parasitic liver worm infection, comparable to that measured in recent years. However, other stock parameters (size structure, size at maturity, stock distribution) are currently in their worst states over the past 80 years. In contrast, the state of cod in the 1970s to early 1990s that is often perceived as a desirable target, was exceptional, with the most favorable indicator levels in the time series. Long-term observation data reveal concurrent or asynchronous trends in different indicators of stock health and to what extent these have coincided with changes in possible external drivers. In this way, the extended time series contribute to ongoing research on understanding the collapse of the cod and its recovery potential.
Understanding of arthrofibrosis: New explorative insights into extracellular matrix remodeling of synovial fibroblasts
Authors: Ly Thanh-Diep , Sambale Meike , Klösener Lara , Traut Philipp , Fischer Bastian , Hendig Doris , Kuhn Joachim , Knabbe Cornelius , Faust-Hinse Isabel
Published: May 2023

Arthrofibrosis following total knee arthroplasty is a fibroproliferative joint disorder marked by dysregulated biosynthesis of extracellular matrix proteins, such as collagens and proteoglycans. The underlying cellular events remain incompletely understood. Myofibroblasts are highly contractile matrix-producing cells characterized by increased alpha-smooth muscle actin expression and xylosyltransferase-I (XT-I) secretion. Human XT-I has been identified as a key mediator of arthrofibrotic remodeling. Primary fibroblasts from patients with arthrofibrosis provide a useful in vitro model to identify and characterize disease regulators and potential therapeutic targets. This study aims at characterizing primary synovial fibroblasts from arthrofibrotic tissues (AFib) regarding their molecular and cellular phenotype by utilizing myofibroblast cell culture models. Compared to synovial control fibroblasts (CF), AFib are marked by enhanced cell contractility and a higher XT secretion rate, demonstrating an increased fibroblast-to-myofibroblast transition rate during arthrofibrosis. Histochemical assays and quantitative gene expression analysis confirmed higher collagen and proteoglycan expression and accumulation in AFib compared to CF. Furthermore, fibrosis-based gene expression profiling identified novel modifier genes in the context of arthrofibrosis remodeling. In summary, this study revealed a unique profibrotic phenotype in AFib that resembles some traits of other fibroproliferative diseases and can be used for the future development of therapeutic interventions.
A Study for Improvement of Perfor mance-based Reservoir Condition Evaluation
Authors:   Crisis and Emergency Management: Theory and Praxis, Baik Sangyi , Lee Sungsu , Lee Seulgi
Published: May 2023

More than 50% of domestic agricultural reservoirs were built before 1945, which increases defects due to deterioration of facilities and limits their original function. Agricultural reservoirs are required for evaluation of the condition through regular inspections conducted at least once a quarter every year; however, the average execution rate per quarter was 45% according to the inspection records made by local governments over the past five years. Combining the low inspection rate in practice and the aged status of the facilities results in higher probability of reservoir failures especially for small reservoirs accounting for more than 90% of them managed by local governments. In this regard, the improvement plans were proposed in this paper through performance-based inspections. The improvement of the reservoir condition evaluation will enable rapid response to the aged reservoirs and reduce the potential damage caused by disasters through preemptive safety management.
A Study on the Development of Evaluation Indicators in the Business Continuity Management System: Focusing on the ‘Leadership’ in the Plan of the ISO 22301
Authors:   Crisis and Emergency Management: Theory and Praxis, Jung Young-Kyun , Cheung Chong-Soo
Published: May 2023

This paper aims to develop evaluation indicators of Leadership part in the PDCA(Plan-Do-Check-Act) requirements of ISO 22301(2019) which is an international standard for Business Continuity Management System(BCMS). The research method is that panel of 20 experts in the area of BCMS reviewed for the validity of the detailed evaluation indicators of Leadership part through the modified Delphi technique and relative importance are surveyed by the panel group based on the AHP(Analysis Hierarchy Process). As the results, the 15 evaluation indicators that could be applied for BCMS evaluation for the organizations are selected and for the quantified evaluation model, score indicators out of 1,000 are applied to convert them into points for individual evaluation indicators. In the conclusion, in order to develop a quantitative evaluation indicators of the BCMS, it is concluded that evaluation should be selected and given relative importance so that they can be used for effective evaluation.
Factors Affecting Nursing Students' Quality of Life
Authors:   Crisis and Emergency Management: Theory and Praxis, Jeon Mi-Kyeong
Published: May 2023

The purpose of this study is to identify nursing students' college life stress, family strengths and to identify factors that affect the quality of life of nursing students. Data were collected from 200 nursing students between April 20th to May 24th, 2018 from a college in A city. Data were analyzed using descriptive statistics, t-tests, a one-way ANOVA, Pearson correlation, and multiple regression. All analyzes were conducted using IBM SPSS 22.0. The results of the multiple regression analysis showed that the regression model was significant (F=14.57, p<.001). The factors affecting the quality of life were family strengths (β=.36, p<.001), high satisfaction in university (β=.30, p=.002), college life stress (β=-.20, p=.002). This regression model was explained by 41% of variances in the quality of life of nursing students. To enhance the quality of life of nursing students it is necessary to analyze college life stress and to assess family strength to relieve stress. In addition, universities need to make efforts to improve overall nursing students' satisfaction with the university by investing and providing continuous support for education and facilities that meet the demands of students.
Productive Zakat as Economic Empowerment Mustahiq Amil Zakat Institute Daarut Tauhid Peduli Lampung
Authors: Mustofa Ulul Azmi , Novita Resilia
Published: May 2023

Abstract: Poverty is not just an individual or personal problem, but poverty is a common problem. The Amil Zakat Institute Daarut Tauhid Cares Lampung with the productive zakat program must be able to answer these problems. This study aims to determine the mechanism and pattern of productive zakat empowerment applied by LAZ Daarut Tauhid Peduli Lampung and want to know its impact on mustahik. This type of research is a field research conducted at LAZ Daarut Tauhid Peduli Lampung. The results of this study are the mechanisms and patterns used for empowerment in LAZ Daarut Tauhid Lampung are using the Economic Care program (Misykat program, Independent Cattle Village, and Independent Farming Business), this program focuses on capital loans in helping Mustahik's economic empowerment. The Economic Care Program is beneficial for the economic empowerment of Mustahik (increasing income, knowledge, independence and independence).Abstrak: Kemiskinan bukan hanya permasalahan individu atau personal, tetapi kemiskinan merupakan permasalahan bersama. Lembaga Amil Zakat Daarut Tauhid Peduli Lampung dengan adanya program zakat produktif harus mampu untuk memjawab permasalahan tersebut. Penelitian ini bertujuan untuk mengetahui mekanisme dan pola pemberdayaan zakat produktif yang duterapkan oleh LAZ (Lembaga Amil Zakat) Daarut Tauhid Peduli Lampung dan ingin mengetahui dampaknya terhadap mustahik. Jenis penelitian ini adalah penelitian lapangan yang dilakukan di LAZ (Lembaga Amil Zakat) Daarut Tauhid Peduli Lampung. Hasil dari penelitian ini adalah mekanisme dan pola yang digunakan untuk pemberdayaan di LAZ (Lembaga Amil Zakat) Daarut Tauhid Lampung adalah menggunakan program Peduli Ekonomi (program Misykat, Desa Ternak Mandiri, dan Usaha Tani Mandiri), program ini terfokus pada pinjaman modal dalam membantu pemberdayaan ekonomi Mustahik. Program Peduli Ekonomi bermanfaat bagi pemberdayaan ekonomi para Mustahik (peningkatan pendapatan, pengetahuan, kemandirian dan kemndirian).
SDGs and Islamic Studies: Fiqh Muamalat, Sustainable Development, and Maqashid Asy-Syari’ah
Authors: Abdurrahman Landy Trisna , Saifullah Ulinnuha , Darussalam Ishlahu , Arkham Sitta A’la
Published: May 2023

Sustainable development Goals (SDGs) are a form of development, or even a further form of the Millennium Development Goals (MDGs). The SDGs, which contain 17 Goals and 169 Targets, are a global action plan for the next 15 years (effective from 2016 to 2030), to end poverty, reduce inequality and protect the environment. This discourse on SDGs is a global discourse, Muslims, as a part of the global order, are also part of this discourse. In the SDGs discourse as a global discourse, the SDGs need to be studied through Islamic studies. This paper tries to portray how the SDGs are studied through Islamic studies, especially in relation to the scientific discipline of fiqh. This study is considered necessary because fiqh is often considered as something final and sacred, while the SDGs are something “new” and dynamic. This paper tries to find a meeting point between fiqh as an Islamic study, and the SDGs as a global discourse. The results in this paper show that fiqh, as a scientific discipline, also has future-oriented dimensions through empirical evidence in classical fiqh literature and empirical evidence in the form of developing a methodology for finding Islamic law (fiqh). In addition, SDGs can be proposed as the main theme for the benefit of mankind as a benchmark and measuring instrument to measure the level of achievement of Maqashid Ash-Shari'ah in the contemporary era.
The Nisbah of Indomaret Musyarakah Franchise in Indonesia: MUI Approach
Authors: Fauzi Inna
Published: May 2023

Abstract: The retail industry is an Indonesian business that provides basic needs and daily needs. This industry is engaged in a promising trading business. Conducting joint ventures with the public and business entities who wish to open a business in the field of trade (business retail) with a franchise system. On the other hand, the concept of cooperation promoted by the DSN MUI fatwa No. 08/DSN-MUI/IV/2000 must also continue to be applied for the realization of the Musyarakah concept. The purpose of this study was to find out how the calculation of the musharaka ratio of retail products at Indomaret in Kudus and how to analyze the fatwa of DSN MUI No 08/DSN-MUI/IV/2000 on the implementation system of calculating the musharaka ratio of retail products at Indomaret in Kudus. This study uses a qualitative descriptive method with a juridical-empirical approach. The results showed that the calculation of the musharaka ratio for retail products at Indomaret in Kudus was not in accordance with Islamic law through the fatwa of DSN MUI No 08/DSN-MUI/IV/2000 on the principle of Distribution of Business Results. In addition, the implementation system for calculating the musharaka ratio for retail products at Indomaret in Kudus tends to be subjective, not as in the Qur'an letter an-Nahl:9.Abstrak: Industri ritel merupakan bisni Indonesia yang menyediakan kebutuhan pokok dan kebutuhan sehari-hari. Industri ini bergerak dalam bidang usaha perdagangan yang cukup menjanjikan Mengadakan kerja sama (joint venture) dengan masyarakat dan badan usaha yang ingin membuka usaha dalam bidang perdagangan (businessretail) dengan sistem waralaba. D isisi lain, konsep kerja sama yang diusung oleh fatwa DSN MUI No 08/DSN-MUI/IV/2000 juga harus berus diterapkan demi terwujudnya konsep Musyarakah. Tujuan penelitian ini adalah untuk mengetahui bagaimana pelaksanaan perhitungan nisbah musyarakah produk retail pada Indomaret di Kudus serta bagaimana analisa fatwa DSN MUI No 08/DSN-MUI/IV/2000 terhadap sistem pelaksanaan perhitungan nisbah musyarakah produk retail pada Indomaret di Kudus. Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan yuridis-empiris. Hasil penelitian menunjukkan bahwa pelaksanaan perhitungan nisbah musyarakah produk retail pada Indomaret di Kudus tidak sesuai dengan Hukum Islam melalui fatwa DSN MUI No 08/DSN-MUI/IV/2000 tentang prinsip Distribusi Hasil Usaha. Selain itu, sistem pelaksanaan perhitungan nisbah musyarakah produk retail pada Indomaret di Kudus cenderung bersifat subjektif tidak sebagaimana dalam al-Qur’an surat an-Nahl ayat 9.
Modest Molinism
Authors: Bergmann Michael
Published: May 2023

Molinism, which says that God has middle knowledge, offers one of the most impressive and popular ways of combining libertarian creaturely freedom with full providential control by God.  The aim of this paper is to explain, motivate, and defend a heretofore overlooked version of Molinism that I call ‘Modest Molinism’.  In Section 1, I explain Modest Molinism and make an initial case for it. Then, in Sections 2 and 3, I defend Modest Molinism against Dean Zimmerman’s anti-Molinist argument, which is directed at all versions of Molinism, including Modest Molinism.  Zimmerman’s anti-Molinist argument combines two distinct and separable challenges to Molinism that I call the ‘Irrelevance Objection’ and the ‘Extreme Manipulation Objection’. Despite the fact that Zimmerman intertwines these two objections, they require separate treatment. Thus, Section 2 will raise concerns about Zimmerman’s Irrelevance Objection and Section 3 will focus on concerns about Zimmerman’s Extreme Manipulation Objection.
Control domótico y monitoreo por medio de IOT
Authors: Reina-Cufiño Manuel Ricardo
Published: May 2023

En este documento se presenta el proceso desarrollado como opción de grado con el diseño e implementación de un prototipo  de un sistema de Control Domótico y monitoreo por medio de IoT para personas en condición de discapacidad visual utilizando comandos de voz, en el cual se evidencia el uso de una Intel galileo de segunda generación tarjeta en la cual se realizó la programación correspondiente al control domótico por medio de comandos de voz haciendo uso del IDE de Arduino, junto con una App inventor en la cual se efectúa el reconocimiento de los comandos enviados a la placa de procesamiento de Intel mediante un celular con sistema operativo android, de igual forma se realizó el monitoreo de variables como temperatura y ritmo cardíaco por medio de la plataforma Ubidots de IoT mediante el uso de un Arduino uno, junto con un escudo Ethernet para poder así visualizar dichas variables, al igual que generar un mensaje de alerta a nuestro teléfono móvil informándonos que se ha producido una anomalía en los parámetros preestablecidos con anterioridad en la plataforma, también es necesario mencionar algunas pruebas realizadas frente a algunas de las potencialidades que posee la Intel galileo como una prueba realizada en el software python al comprobar su conectividad  y el funcionamiento con los pines de salida de la tarjeta.
Book review of: Breuste, Jürgen (2022): Die wilde Stadt. Stadtwildnis als Ideal, Leistungsträger und Konzept für die Gestaltung von Stadtnatur
Authors: Haase Dagmar
Published: May 2023

Book review
Vorwort
Authors: Hejhalová Věra , Šemelík Martin
Published: May 2023

Editorial
Brandes in the Czech-speaking World: Dismissed as a Critic, Embraced as a Name
Authors: Březinová Helena , Lainto Jana
Published: May 2023

In our contribution, we explore the Czech-speaking discourse related to Georg Brandes in the Bohemian Lands in the late nineteenth and the early twentieth century, which means before and shortly after Czechs gained their independence from Austria-Hungary in 1918. Our research of archival sources, especially periodicals and private letters, enables us to confidently claim that the impact of Brandes’s criticism on the Czech arts was rather insignificant. At the same time, the sources give a clear picture that the Czech-speaking intelligentsia were interested in using Brandes’s symbolic capital to promote their struggle for Czech cultural autonomy. Thus, it was not Brandes’s works that can be considered influential in the Czech context but his persona. This strategy of using Brandes’s symbolic capital mirrors his own efforts to be viewed as an international intermediary. Finally, we explore the East-West dynamics in Brandes’s relationship with Czechs and vice versa, and here, we identify a considerable asymmetry
The Early Reception of Georg Brandes in Germany and France. A Comparative Study
Authors: Jelsbak Torben
Published: May 2023

The publication of Emigrant Literature, the first volume of Main Currents in Nineteenth Century Literature (1872–1890), constituted Georg Brandes’ breakthrough work and the beginning of his career as a European literary critic. However, the work was very differently received in the two major literary cultures of the time, Germany and France. In the German press, Brandes was saluted as a cultural reformer and icebreaker of literary modernity, “a good European and cultural missionary”, as Friedrich Nietzsche called him in a letter from 1887, whereas French critics reacted with much greater skepticism to Brandes’ work. This situation was especially annoying to Brandes as he regarded French literary and intellectual culture as superior to any other culture of the world and more than anything else he longed for recognition from the French literati. The uneven distribution of critical acclaim was a paradox that also affected Brandes’ self-understanding and position as a lcritic. The following article will examine this tension by providing a comparative study of the reception of Emigrant Literature in Germany and France from 1872 to 1893.
Johanna Laakso (Ed.). Ways of Being in the World: Studies on Minority Literatures
Authors: Střížková Dominika , Dlask Jan , Kovář Michal
Published: May 2023

Book review on Johanna Laakso (Ed.). Ways of Being in the World: Studies on Minority Literatures. Central European Uralic Studies, volume 1. Praesens Verlag, Wien 2020, 196 p.
Bildgrammatik. Gebrauch der Visualisierungen in den Lerner-Grammatiken der deutschen Sprache
Authors: Felbr Lukáš
Published: May 2023

This paper analyses the role of visualisations in grammar books for learners of German as a foreign language. It evaluates a sample of grammar books self-labelled as pictorial as well as other grammar books designated for non-native speakers of German. The analysis focuses not only on pictures, but on all the visual means that grammars use to convey grammatical rules. The aim of the study is to provide a better understanding of didactic and cognitive-linguistic aspects of the grammar transmission. In order to do so, it inquires into the usage of visual metaphors and mnemonic devices. Though the benefits of such types of visualisations have repeatedly been proven, they appear only seldom in the analysed grammar books as most of the visualisations depict only the semantics of example sentences. The article presents concrete cases to illustrate both problematic uses of visualisations and examples of good practice that can serve not only as a starting point for further didactic contributions in this field but also as suggestions for teachers of German or authors of teaching materials.
The influence of acute dietary nitrate supplementation on skeletal muscle fatigue and recovery in older women
Authors: Zoughaib William S. , Hoffman Richard L. , Yates Brandon A. , Moorthi Ranjani N. , Lim Kenneth , Coggan Andrew R.
Published: May 2023

Older individuals fatigue more rapidly during, and recover more slowly from, dynamic exercise. Women are particularly vulnerable to these deleterious effects of aging, which increases their risk of falling. We have shown that dietary nitrate (NO3−), a source of nitric oxide (NO) via the NO3− → nitrite (NO2−) → NO pathway, enhances muscle speed and power in older individuals in the non‐fatigued state; however, it is unclear if it reduces fatigability and/or improves recoverability in this population. Using a double‐blind, placebo‐controlled, crossover design, we studied 18 older (age 70 ± 4 years) women who were administered an acute dose of beetroot juice (BRJ) containing either 15.6 ± 3.6 or <0.05 mmol of NO3−. Blood samples were drawn throughout each ~3 h visit for plasma NO3− and NO2− analysis. Peak torque was measured during, and periodically for 10 min after, 50 maximal knee extensions performed at 3.14 rad/s on an isokinetic dynamometer. Ingestion of NO3−‐containing BRJ increased plasma NO3− and NO2− concentrations by 21 ± 8 and 4 ± 4 fold, respectively. However, there were no differences in muscle fatigue or recovery. Dietary NO3− increases plasma NO3− and NO2− concentrations but does not reduce fatigability during or enhance recoverability after high intensity exercise in older women.
Cage restriction‐induced physical inactivity promotes subsequent hepatic apoptosis during tail suspension in young male rats
Authors: Dobashi Shohei , Naito Hisashi , Yoshihara Toshinori
Published: May 2023

This study investigated the impact of long‐term physical inactivity on hepatic cytoprotective‐ and inflammatory‐related protein expressions in young rats and the subsequent apoptotic response during microgravity stress simulated by tail suspension. Four‐week‐old male Wistar rats were randomly assigned to the control (CT) and physical inactivity (IN) groups. The floor space of the cages provided to the IN group was reduced to half of that provided to the CT group. After 8 weeks, rats in both groups (n = 6–7) underwent tail suspension. Their livers were harvested immediately before (0 day) or 1, 3, and 7 days after tail suspension. Levels of hepatic heat shock protein 72 (HSP72), an anti‐apoptotic protein, reduced over 7 days of tail suspension in the IN group than in the CT group (p < 0.01). Fragmented nucleosomes in the cytoplasmic fraction of the liver, an apoptotic index, were drastically increased by physical inactivity and tail suspension, and this change was significantly greater after 7 days of tail suspension in the IN group than in the CT group (p < 0.01). The apoptotic response was accompanied by the upregulation of pro‐apoptotic proteins (cleaved caspase‐3 and ‐7). Moreover, the levels of other pro‐apoptotic proteins (tumor necrosis factor‐1α and histone deacetylase 5) were also significantly higher in the IN than in the CT group (p < 0.05). Our results indicated that 8 weeks of physical inactivity decreased hepatic HSP72 levels and promoted hepatic apoptosis during the subsequent 7 days of tail suspension.
Enhancing the efficiency of polytetrafluoroethylene-modified silica hydrosols coated solar panels by using artificial neural network and response surface methodology
Authors: Ramasamy Kirthika , Murugesan Chandrasekar , Thamilkolunthu Senthilkumar
Published: May 2023

In this article, an attempt was made to improve the efficiency of coated solar panels by using artificial neural networks (ANNs) and response surface methodology (RSM). Using the spray coating technique, the glass surface of the photovoltaic solar panel was coated with silicon dioxide nanoparticles incorporated with polytetrafluoroethylene-modified silica sols. Multilayer perceptron with feed-forward back-propagation algorithm was used to develop ANN models for improving the efficiency of the coated solar panels. Out of the 200 sets of data collected, 75% were used for training and 25% were used for testing. On evaluating the models using performance indicators, a four-input technological parameter model (silicon dioxide nanoparticle quantity, coating thickness, surface temperature and solar insolation) with eight neurons in a single hidden layer combination was observed to be the best. The prediction accuracy indicator values of the ANN model were 0.9612 for the coefficient of determination, 0.1971 for the mean absolute percentage error, 0.2317 for the relative root mean square error and 0.00741 for the mean bias error. Using a central composite design model, empirical relationships were developed between input and output responses. The significance of the developed model was ascertained by using analysis of variance, up to a 95% confidence level. For optimization, the RSM was used, and a high efficiency of 17.1% was predicted for the coated solar panel with optimized factors; it was validated to a very high level of predictability. Using interaction and perturbation plots, a ranking of the parameters was done.
Implementing Antitrust Regulations in Dynamic Industries: The Case of the U.S. Cottonseed Industry
Authors: Magnier Alexandre , Kalaitzandonakes Nicholas , Allen Marcus Tim
Published: May 2023

In this paper, we reconsider the rationale used to justify a complaint filed by the U.S. Department of Justice regarding the acquisition of a cottonseed company by an agricultural biotechnology company. With the benefit of hindsight, we show that the competitive assessment overlooked significant market developments that were altering the competitive position of the firms under investigation. This review is intended to raise awareness of the complexities of enforcing antitrust policy in a dynamic environment, with a special emphasis on agricultural markets. We argue that antitrust analysis should incorporate a process view of competition to better account for present market dynamics and the everchanging competitive environment.
Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
Authors: Yang Gangqi , Li Hongyan , Dong Zheng , Deng Kai , Lu Yinying
Published: May 2023

The chemokine, C-X-C motif chemokine ligand 12 (CXCL12) and its G-protein-coupled receptor (GPCR) and C-X-C chemokine receptor type 4 (CXCR4), are closely associated with promoting hepatocellular carcinoma (HCC) chemotaxis and metastasis. The binding of CXCL12 and CXCR4 depends on the heterotrimeric Gi proteins to regulate actin polymerisation and mobility in HCC. Although the role of GPCR/Gi signalling in carcinogenesis migration has been intensively studied, the detailed mechanism remains largely unknown. In this study, a small interfering RNA technique was used to knock down the Nucleophosmin 1 (NPM1) gene expression. Through the chemotaxis and invasion assays, wound healing, proliferation, filamentous-actin, immunofluorescence, immunohistochemical assays, and co-immunoprecipitation assays, we investigated the specific biological role and underlying mechanisms of the NPM1 in HCC. Additionally, dimethyl fumarate (DMF), a fumaric acid ester, was used to inhibit the HCC cell chemokines and metastasis by regulating ELMO1 and NPM1. Therefore, this study reported that NPM1 gene expression was upregulated in the HCC tissues and cell lines. The NPM1 knockdown significantly inhibited the proliferation, migration, and chemotaxis of the HepG2 cells in vitro. Further mechanistic studies suggested that the NPM1 interacts with ELMO1 and the CXCL12/CXCR4 pathway activates NPM1-dependent regulation of the ELMO1 localisation. Furthermore, the DMF significantly inhibited tumour metastasis induced by the NPM1/ELMO1 signalling pathway, as observed in in vitro cell functional experiments. These data suggested that as a potentially novel therapeutic approach, the simultaneous targeting of NPM1 and ELMO1 could effectively be used to treat HCC.
Selbstfürsorge älterer Menschen durch die Selbstanwendung von Hausmitteln – Eine Analyse im Rahmen der HoPES3-Studie
Authors: Stolz Regina , Klocke Carina , Schalhorn Friederike , Mächler Ruth , Frick Eckhard , Strassner Cornelia , Sturm Noemi , Joos Stefanie , Valentini Jan
Published: May 2023

Hintergrund: Hausmittel (HM) gelten als Ressource der Selbstfürsorge bei chronischen Erkrankungen. In der BMBF-geförderten, cluster-randomisierten HoPES3-Studie wurde die Nutzung von HM durch ältere Patient/-innen untersucht. Ziel war es, die Aspekte Spiritualität, soziale Aktivität und Selbstfürsorge (durch Beratung zu HM) in der hausärztlichen Versorgung zu stärken.

Fragestellungen: Welche Maßnahmen sind zur Selbstfürsorge älterer Menschen geeignet? Wie hoch ist die Anzahl der HM Nutzer/-innen? Welche HM Arten werden angewendet? Welche Einstellungen und Beweggründe haben ältere Patient/-innen hinsichtlich HM Anwendung?

Methode: Entwicklung von Infozepten (Anleitungen zur Selbstanwendung von Hausmitteln), Fragebogengestützte Erhebung der teilnehmenden Patient/-innen (n= 297). Leitfadengestützte Interviews mit Patient/-innen (n=29).

Ergebnisse: Es wurden 17 Infozepte entwickelt. Zu Studienbeginn nutzten 33 % der Patient/-innen der Interventionsgruppe (IG) und 39 % der Kontrollgruppe (KG) HM. Nach sechs Monaten waren es 47 % (IG) und 35 % (KG). Zentrale Beweggründe scheinen die Stärkung der Selbstwirksamkeit, das Gefühl der Selbstbestimmtheit im Umgang mit der eigenen Gesundheit und die Vermeidung von Medikamenten zu sein.

Diskussion und Schlussfolgerung: Die Ergebnisse können dazu beitragen die Ressource HM besser in die Therapieentscheidung bei älteren Patient/-innen einzubeziehen. Die Beratung zu HM in der hausärztlichen Praxis könnte eine niederschwellige Maßnahme zur gezielten Stärkung der Selbstwirksamkeit und Lebensqualität von älteren Patient/-innen sein.
Preseason Integrative Neuromuscular Training Improves Selected Measures of Physical Fitness in Highly Trained, Youth, Male Soccer Players
Authors: Hammami Raouf , Negra Yassine , Nebigh Amar , Ramirez-Campillo Rodrigo , Moran Jason , Chaabene Helmi
Published: May 2023

Hammami, R, Negra, Y, Nebigh, A, Ramirez-Campillo, R, Moran, J, and Chaabene, H. Preseason integrative neuromuscular training improves selected measures of physical fitness in highly trained, youth, male soccer players. J Strength Cond Res 37(6): e384–e390, 2023—This study examined the effects of an 8-week integrative neuromuscular training (INT) program, including balance, strength, plyometric, and change of direction exercises, on measures of physical fitness in youth male soccer players. Twenty-four male soccer players participated in this study. They were randomly allocated into an INT (n = 12; age = 15.7 ± 0.6 years, body height = 179.75 ± 6.54 cm, body mass = 78.20 ± 7.44 kg, maturity-offset = +2.2 ± 0.6 years) or an active control (CG, n = 12; age = 15.4 ± 0.8 years, body height = 178.4 ± 6.4 cm, body mass = 72 ± 8.3 kg, maturity-offset = +1.9 ± 0.7 years) group. Before and after training, tests to measure dynamic balance (Y-Balance test [YBT]), muscle strength (one repetition maximum [1RM]), muscle power (five jump test [FJT], single-leg hop test [SLHT], and countermovement jump [CMJ] height), linear sprint time (10 and 30-m), and change of direction with ball (CoDball) were performed. The analysis of covariance was used to test between-group differences (INT vs. CG) at posttest using baseline values as covariates. Significant, large, between-group differences at posttest were noted for the YBT (p = 0.016; d = 1.1), 1RM (p = 0.011; d = 1.2), FJT (p = 0.027; d = 1.0), SLHT (p = 0.04; d = 1.4), CMJ height (p < 0.001; d = 1.9), 10-m sprint (p < 0.01; d = 1.6), and CoDball (p < 0.05; d = 0.9) in favor of the INT group. Significant moderate-to-large pre-to-post changes were detected in the INT group for YBT, 1RM, CMJ height, SLHT, FJT, 10-m and 30-m sprint time, and CoDball test (d = 0.7 to 3.07, p < 0.05). No significant pre-to-post changes were observed in the CG (p > 0.05), except for 10-m sprint time (d = 1.3; p < 0.05). Exposure to INT twice weekly is effective and time efficient to improve various measures of physical fitness in highly trained youth male soccer players.
Toward Professionalization of the Strength and Conditioning Field
Authors: Altiner Baykal M. L. , Dixon Marlene A. , Nite Calvin , Stock Matt S.
Published: May 2023

Collectively, strength and conditioning (S&C) as an industry has experienced immense growth since its emergence, both as an occupation and as an applied science. As a result, coaches continue to lend their expertise to new contexts, encourage empirical research, and persistently engage in the processes of professionalization to improve S&C credentialing and expertise. Despite tremendous progress, the authors encourage industry leaders (professional associations and individuals) to reflect on the industry's origins and infrastructure dynamics concerning the accreditation, education, credentials, and overall professional development of S&C practitioners. As a field, S&C is in a prime position to develop and implement an effective regulatory system toward increased professionalism and effective practice. Thus, this article introduces conceptual tools from organizational behavior to better support S&C professionalization efforts. First, the topic of professions and institutional work is introduced and defined. Second, the relationship between professionals (individual and collective) and institutions during professionalization is illustrated. Third, a reflexive overview of research concerning contemporary issues and trends in the field (i.e., field disparity, credentialing, negligence and injury, and social capital) related to professionalism is highlighted. Finally, precise institutional work strategies and their applications are offered to support the industry's maturation as a profession.
Clonal variation based on some morphological and micromorphological characteristics in the Boyabat (Sinop/Turkey) black pine (Pinus nigra subsp. pallasiana (Lamb.) Holmboe) seed orchard
Authors: Yigit Nurcan , Öztürk Ayşe , Sevik Hakan , Özel Halil Barış , Kshkush Fathi Elmabruk Ramadan , Işık Berkant
Published: May 2023

Seed orchards with high hereditary qualities and the improvement studies used are of great importance. This study was carried out on individuals in a Boyabat grafted black pine seed orchard, Sinop. The morphological and micromorphological measurements of the characteristics were performed on needle samples taken from individuals, and the genetic diversity was determined on a clonal basis. According to the analysis of variance applied to the data obtained from the measurements and the morphological and micromorphological characters of the clones, it was determined that there was a significant difference among the clones at the P<0.001 confidence level. In this context, according to Duncan’s Range test, the creation of a large number of groups is an indicator of it. The highest heritability rates were obtained in needle diameter, stipule diameter, number of the dorsal stoma, and needle length characteristics.
Los nombres del racismo en México: una mirada léxica
Authors: Colín Marisela
Published: May 2023

El propósito del estudio es analizar los nombres con los que se designa al racismo en México; así como la relación de su léxico con fenómenos como el etnicismo, la discriminación y el clasismo. El marco teórico se construye a partir de investigaciones sobre el racismo actual (Castellano, 2000; Gall, 2014, 2004), estudios lexicológicos (Atunes, 2012; Lara, 2006) y discursivos (Hall, 1992). Para lograr el objetivo se trabaja con un corpus de textos de opinión integrado por 109 comentarios escritos de manera anónima en respuesta a cuatro textos disparadores en los que se preguntaba si el racismo existe o no en México y un texto mediador que promovía la participación de los lectores de un periódico mexicano Online. Los datos se estudian en dos fases: inicialmente, mediante un análisis de contenido (Bardin, 2002) se trabaja en el nivel léxico de los textos identificando los temas y organizándose por categorías semánticas; segundo, los textos se analizan cuantitativamente mediante la aplicación AntConc.exe (Anthony, 2022). Los resultados muestran las denominaciones respecto al racismo, sus asociaciones semánticas más frecuentes y la interseccionalidad que puede ser observada en la cotidianeidad.
Fechorías de nuevo cuño: neologismos de la delincuencia
Authors: Cañete-González Paola , Adam Carolin , Blanco Oscar , Garidel Carole , Becerra Constanza
Published: May 2023

En los últimos años, factores de cambio como la evolución de la sociedad y la tecnología han propiciado la circulación de palabras nuevas en distintos ámbitos, como la delincuencia. El objetivo de este trabajo es estudiar la productividad neológica de esta área e identificar los recursos lingüísticos utilizados para la creación de nuevas lexías. Esto se ha podido constatar en la prensa, un medio idóneo para el estudio de la neología porque aborda temas de actualidad y facilita la instauración de nuevas voces en la lengua. Por ello, se seleccionaron cinco periódicos chilenos de 2020 y 2021 (versión digital), se recopilaron —según los criterios psicolingüístico y lexicográfico— unidades léxicas relacionadas con la delincuencia, y se clasificaron en seis categorías. Luego, se identificaron los procedimientos de creación léxica más frecuentes para mostrar las nuevas prácticas delictivas de la sociedad y cómo la lengua permite visibilizarlas creando nuevas unidades. Los resultados revelaron una tendencia a la sintagmación a partir de delitos existentes (secuestro extorsivo), a la sufijación (portonazo), a la composición (cibersabotaje) y a la neología semántica (vaquero). Así, se confirmó que el léxico es una fuente inagotable de creación de neologismos que permite expresar nuevas realidades y dinámicas sociales.
Role of Imaging in Cardiomyopathies
Authors: Castiglione Vincenzo , Aimo Alberto , Todiere Giancarlo , Barison Andrea , Fabiani Iacopo , Panichella Giorgia , Genovesi Dario , Bonino Lucrezia , Clemente Alberto , Cademartiri Filippo , Giannoni Alberto , Passino Claudio , Emdin Michele , Vergaro Giuseppe
Published: May 2023

Imaging has a central role in the diagnosis, classification, and clinical management of cardiomyopathies. While echocardiography is the first-line technique, given its wide availability and safety, advanced imaging, including cardiovascular magnetic resonance (CMR), nuclear medicine and CT, is increasingly needed to refine the diagnosis or guide therapeutic decision-making. In selected cases, such as in transthyretin-related cardiac amyloidosis or in arrhythmogenic cardiomyopathy, the demonstration of histological features of the disease can be avoided when typical findings are observed at bone-tracer scintigraphy or CMR, respectively. Findings from imaging techniques should always be integrated with data from the clinical, electrocardiographic, biomarker, genetic and functional evaluation to pursue an individualised approach to patients with cardiomyopathy.
Simulation of density, viscosity and ultrasonic velocity data of 3-bromoanisole + methanol mixtures at different temperatures
Authors: Jouyban Abolghasem
Published: May 2023

Aim: To represent mathematically the reported physico-chemical properties (PCPs) of binary mixtures of 3 bromoanisol + methanol at various temperatures by using a single model with seven curve-fit parameters. Results: Besides the correlation models, the applicability of training the proposed model using a minimum number of experimental data and prediction of the rest of data points with acceptable prediction error is also shown.
Interactional functions of therapists’ reformulations in a group session involving French-speaking children with autism spectrum disorder
Authors: Wiklund Mari , Määttä Simo
Published: May 2023

Background: In this article, we analyze a group therapy session involving four 11- to 13-year-old French-speaking boys with autism spectrum disorder (ASD) and their two female therapists. We focus on speaking turns in which the therapists reformulate the contents of a preceding turn produced by a child. Method: Methodologically, the study is based mainly on conversation analysis. Results: The analyses show that the therapists clearly aim to achieve meaningful learning outcomes with regard to the topic of conversation, and the reformulations constitute an essential tool in this process. Most often, reformulations are used to provide a more compact and more effective formulation of the turn in terms of the topic of conversation. Sometimes, a reformulation is used to assist a speaker who is experiencing problems with the formulation of their utterances. The reformulations also often include signs of approval and constitute positive feedback for the children. In some contexts, for example, in the case of turns including sensitive content, reformulations can constitute a strategy of avoiding repetition.
Rol de las mujeres en la conservación de la cerámica de Cácota como patrimonio cultural de Norte de Santander Colombia en el marco de la economía naranja.
Authors: Carvajal-Rodríguez Julio César , Núñez-Rodríguez José de Jesús , Carrillo-Guecha Angélica Alexandra
Published: May 2023

La presente investigación tiene como propósito el proceso de reconstrucción de los saberes ancestrales de la cerámica Cacoteña, resaltando el rol determinante que han desarrollado las mujeres artesanas desde sus orígenes y su papel en el desarrollo y conservación de éste patrimonio cultural, uno de los más importantes en Colombia.

La reconstruir de los saberes cerámicos permitirá a las mujeres artesanas incorporarlas en los procesos de elaboración y producción, a través de las capacitaciones en nuevas técnicas, en donde se integre lo biocultural   y pedagógico, logrando de ésta forma la inserción en el marco de las políticas de la economía naranja, lo que haría más relevante el papel de ésta en la dinámica no solo cultural sino económica de la región.
Estrategia de apropiación social del conocimiento en la isquemia cardiaca
Authors:   Universidad El Bosque, Bogotá, Colombia, Castillo Sierra Diana Marcela , Vargas Escobar Lina María , Moreno Nieto Melany Johana , Díaz Farfán Sandra Paticia , Rodríguez Marín Karen Tatiana
Published: May 2023

Introducción: La construcción de conocimiento a partir del intercambio de saberes entre pacientes, familias y equipo de salud es una necesidad sentida que puede impactar en la educación en salud y la adherencia a los tratamientos. Objetivo: Desarrollar una estrategia de apropiación social que permita innovar en el cuidado de la salud de las personas con enfermedad isquémica cardiaca y sus familias mediante el uso de la herramienta MHealth. Materiales y Métodos: Estudio exploratorio que permitió el diseño de una estrategia de apropiación social de conocimiento para mejorar la salud cardiovascular de personas que sufren isquemia cardiaca. Participaron 31 personas entre pacientes, familiares, profesionales de la salud. Se desarrollaron dos talleres virtuales en el mes de junio y seguimientos telefónicos entre agosto y septiembre. Las experiencias y saberes de los participantes, permitió la construcción de la herramienta MHealth. Resultados: La reflexión crítica entre los actores facilitó la construcción y desarrollo de la herramienta tipo MHealth (página web/app) titulada “Cuidando tu corazón”, que permite el acceso a información relacionada con el cuidado durante la isquemia cardiaca y articula información a partir del diálogo de saberes y la evidencia reportada en la literatura. Discusión: Las estrategias de apropiación social son una herramienta relevante para la generación de conocimiento en el área de la salud. Conclusiones: La estrategia implementada permitió reconocer la importancia de contar con herramientas para el cuidado de la salud cardiovascular elaboradas desde las necesidades, perspectivas y creencias de sus actores para mejorar la educación y el cuidado.