bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Endoscopic Ultrasound-Guided Hepaticogastrostomy Safe and Effective after Failed Endoscopic Retrograde Cholangiopancreatography?—A Systematic Review and Meta-Analysis
Authors: Alsakarneh Saqr , Madi Mahmoud Y. , Dahiya Dushyant Singh , Jaber Fouad , Kilani Yassine , Ahmed Mohamed , Beran Azizullah , Abdallah Mohamed , Al Ta’ani Omar , Mittal Anika , Numan Laith , Goyal Hemant , Bilal Mohammad , Kiwan Wissam
Published: July 2024

Background/Objectives: Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) has emerged as an alternative option for biliary drainage in cases of failed endoscopic retrograde cholangiopancreatography (ERCP). Limited data exist on the safety and efficacy of EUS-HGS. In this comprehensive meta-analysis, we aim to study the safety and efficacy of EUS-HGS in cases of failed conventional ERCP. Methods: Embase, PubMed, and Web of Science databases were searched to include all studies that evaluated the efficacy and safety of EUS-HGS. Using the random effect model, the pooled weight-adjusted event rate estimate for clinical outcomes in each group were calculated with 95% confidence intervals (CIs). The primary outcomes were technical and clinical success rates. Secondary outcomes included overall adverse events (AEs), rates of recurrent biliary obstruction (RBO), and rates or re-intervention. Results: Our analysis included 70 studies, with a total of 3527 patients. The pooled technical and clinical success rates for EUS-HGS were 98.1% ([95% CI, 97.5–98.7]; I2 = 40%) and 98.1% ([95% CI, 97.5–98.7]; I2 = 40%), respectively. The pooled incidence rate of AEs with EUS-HGS was 14.9% (95% CI, 12.7–17.1), with bile leakage being the most common (2.4% [95% CI, 1.7–3.2]). The pooled incidence of RBO was 15.8% [95% CI, 12.2–19.4], with a high success rate for re-intervention (97.5% [95% CI, 94.7–100]). Conclusions: Our analysis showed high technical and clinical success rates of EUS-HGS, making it a feasible and effective alternative to ERCP. The ongoing development of dedicated devices and techniques is expected to make EUS-HGS more accessible and safer for patients in need of biliary drainage.
The Effects of Multidisciplinary Intensive Rehabilitation on Cognitive and Executive Functions in Parkinson’s Disease: A Clinical Database Analysis
Authors: Baldassarre Ivana , Rotondo Rossella , Piccardi Laura , Leonardi Lorenza , Lanni Danilo , Gaglione Maria , Stocchi Fabrizio , Fini Massimo , Goffredo Michela , Padua Elvira , De Pandis Maria Francesca
Published: July 2024

Background/Objectives: This study is based on data collected from a medical health record review to assess whether multidisciplinary intensive rehabilitation treatment in Parkinson’s disease (PD) patients can improve global cognitive functioning and executive functions. Methods: The data related to PD patients were extrapolated from a clinical database called “NeuroRehab”. A total of 104 PD patients (51 males; 53 females) performed 6 weeks of multidisciplinary intensive rehabilitation treatment in clinical practice from January 2019 to May 2023. This training program was characterized by three daily sessions of 60 min of activities (muscle relaxation and stretching exercises, moderate physical aerobic exercise, and occupational therapy). The patients were classified and stratified according to disease severity (according to the Hoehn and Yahr scale), postural instability and gait difficulty (PIGD) or tremor-dominant (TD) subtypes, disease duration (DD), and the presence of dyskinesias. The effect of multidisciplinary intensive rehabilitation treatment on cognitive and executive functions was evaluated through the administration of cognitive tests, such as the Mini–Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Frontal Assessment Battery (FAB). All the parameters were evaluated at the baseline (T0) and at the end of the rehabilitation program (T1). Results: The multidisciplinary intensive rehabilitation treatment significantly improved cognitive performance. The MMSE, MoCA, and FAB test scores after the rehabilitation program (T1) were significantly higher compared to the scores obtained at the baseline (T0). Moreover, further analyses on subgroups of the patients who scored below the cut-off in the MMSE showed that at least 50% of patients overcame the cut-off score. Interestingly, the same analyses performed for the MoCA and FAB revealed a higher rate of improvement in cognitive functions, with normal scores in both tests after 6 weeks of multidisciplinary intensive rehabilitation treatment. Conclusions: This study revealed the potential effects of a 6-week multidisciplinary rehabilitation program in improving cognitive status in a PD inpatient cohort.
Improving Quality of Life in Bipolar Disorders with an Immersive Virtual Reality Remediation Training Randomized Controlled Trial (RCT)
Authors: Primavera Diego , Migliaccio Gian Mario , Garau Valentino , Orrù Germano , Scano Alessandra , Perra Alessandra , Pinna Samantha , Tusconi Massimo , Carta Mauro Giovanni , Sancassiani Federica
Published: July 2024

Background: Health-related quality of life (H-QoL) is a critical measure in bipolar disorder (BD). Recent trials using virtual reality (VR) have shown potential in improving H-QoL. However, VR’s effect on the H-QoL of people with BD needs to be further explored. Methods: This study involved a secondary analysis of a feasibility randomized controlled trial, focusing on “quality of life”. Participants (aged 18–75) diagnosed with bipolar disorder were randomized into two groups. The experimental group used the CEREBRUM VR app, while the control group received the usual care. Quality of life was assessed using the Short-Form Health Survey (SF-12). Results: A total of 39 individuals in the experimental group and 25 in the control group represent the final samples. The results showed a greater improvement in the SF-12 total score in the experimental group (8.7%) compared to the control group (F = 66.851 p < 0.0001), specifically in the dimension of physical activity limitation, emotional impact, concentration, pain, calmness, energy levels, discouragement, and social activities. Conclusions: This study demonstrated an improvement in QoL for individuals with BD following a VR intervention. As a feasibility study, this secondary outcome needs to be confirmed by further phase III studies. If confirmed, VR could offer valuable rehabilitation tools and insights into the pathogenesis and treatment of BD.
Comparing Complication Rates, Costs, and Length of Stay between Unicompartmental and Total Knee Arthroplasty: Insights from a Big Data Analysis Using the National Inpatient Sample Dataset
Authors: Maman David , Mahamid Assil , Yonai Yaniv , Berkovich Yaron
Published: July 2024

Background: Unicompartmental knee arthroplasty (UKA) is increasingly used for knee osteoarthritis due to faster recovery, better range of motion, and lower costs compared to total knee arthroplasty (TKA). While TKA may offer longer-lasting results with lower revision rates, this study compares the relative benefits and limitations of UKA and TKA using the National Inpatient Sample (NIS) database. Methods: This retrospective analysis examined outcomes of elective UKA and TKA procedures from 2016 to 2019, identifying 2,606,925 patients via ICD-10 codes. Propensity score matching based on demographics, hospital characteristics, and comorbidities resulted in a balanced cohort of 136,890 patients. The present study compared in-hospital mortality, length of stay, postoperative complications, and hospitalization costs. Results: The results showed that UKA procedures increased significantly over the study period. Patients undergoing UKA were generally younger with fewer comorbidities. After matching, both groups had low in-hospital mortality (0.015%). UKA patients had shorter hospital stays (1.53 vs. 2.47 days) and lower costs (USD 55,976 vs. USD 61,513) compared to TKA patients. UKA patients had slightly higher rates of intraoperative fracture and pulmonary edema, while TKA patients had higher risks of blood transfusion, anemia, coronary artery disease, pulmonary embolism, pneumonia, and acute kidney injury. Conclusions: UKA appears to be a less-invasive, cost-effective option for younger patients with localized knee osteoarthritis.
Machine Learning Prediction of Treatment Response to Biological Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis
Authors: Salehi Fatemeh , Lopera Gonzalez Luis I. , Bayat Sara , Kleyer Arnd , Zanca Dario , Brost Alexander , Schett Georg , Eskofier Bjoern M.
Published: July 2024

Background: Disease-modifying antirheumatic drugs (bDMARDs) have shown efficacy in treating Rheumatoid Arthritis (RA). Predicting treatment outcomes for RA is crucial as approximately 30% of patients do not respond to bDMARDs and only half achieve a sustained response. This study aims to leverage machine learning to predict both initial response at 6 months and sustained response at 12 months using baseline clinical data. Methods: Baseline clinical data were collected from 154 RA patients treated at the University Hospital in Erlangen, Germany. Five machine learning models were compared: Extreme Gradient Boosting (XGBoost), Adaptive Boosting (AdaBoost), K-nearest neighbors (KNN), Support Vector Machines (SVM), and Random Forest. Nested cross-validation was employed to ensure robustness and avoid overfitting, integrating hyperparameter tuning within its process. Results: XGBoost achieved the highest accuracy for predicting initial response (AUC-ROC of 0.91), while AdaBoost was the most effective for sustained response (AUC-ROC of 0.84). Key predictors included the Disease Activity Score-28 using erythrocyte sedimentation rate (DAS28-ESR), with higher scores at baseline associated with lower response chances at 6 and 12 months. Shapley additive explanations (SHAP) identified the most important baseline features and visualized their directional effects on treatment response and sustained response. Conclusions: These findings can enhance RA treatment plans and support clinical decision-making, ultimately improving patient outcomes by predicting response before starting medication.
Effect of Laterality in Microsurgery: Comparative Study of an Expert and a Novice
Authors: Guttmann Célia , Timoteo Agata Durdzinska , Durand Sébastien
Published: July 2024

Background: Hand laterality has an impact on surgical gestures. In this study, we sought to measure the multi-parameter variability of the microsurgical gesture depending on the hand used and the differences between expert microsurgeons and novices. Methods: Ten experienced microsurgeons and twenty medical students with no prior microsurgical experience performed arterial anastomosis on a chicken wing artery using dominant and non-dominant hands. We measured time and force using a homemade force-sensing microsurgical needle holder, heart rate variability with a Polar H10 chest strap, anxiety with the STAI-Y questionnaire and anastomosis quality using the MARS 10 scale. Results: In the microsurgeons’ group, duration of anastomosis (p = 0.037), force applied to the needle holder (p = 0.047), anxiety (p = 0.05) and MARS10 (p = 0.291) were better with the dominant hand. For novices, there was no difference between the dominant and non-dominant hand pertaining to force, time and stress level. There were no differences between microsurgeons and novices pertaining to force and anxiety using the non-dominant hand. Conclusions: The study highlighted a marked laterality among microsurgical experts, a finding that may be explained by current learning methods. Surprisingly, no laterality is observed in students, suggesting that for a specific gesture completely different from everyday tasks, laterality is not predefined. Ambidexterity training in the residency curriculum seems relevant and may help microsurgeons improve performance and postoperative outcomes.
Plasma Cytokines for the Prediction of the Effectiveness of TNFα Inhibitors Etanercept, Infliximab, and Adalimumab in the Treatment of Psoriasis
Authors: Karamova Arfenya , Znamenskaya Ludmila , Vorontsova Anastasiia , Obraztsova Olga , Nikonorov Alexandr , Nikonorova Eugenia , Deryabin Dmitry , Kubanov Alexey
Published: July 2024

Background/Objectives: Psoriasis is a chronic, inflammatory, immuno-mediated cutaneous disease characterized by a prominent TNFα-IL23/IL17 immune axis. In recent years, targeted therapies have become standard practice for managing moderate-to-severe psoriasis and have demonstrated efficacy. At the same time, identifying factors associated with the success or failure of TNFα inhibitor therapy remains one of the most difficult aspects in psoriasis treatment. Methods: A clinical, non-randomized study was conducted to evaluate the impact of TNFα inhibitors on the plasma cytokine profiles in patients with moderate-to-severe psoriasis vulgaris (ICD-10 code L40.0). The patients were treated with either etanercept, adalimumab, or infliximab for 16 weeks. Plasma cytokine profiles were assessed using a BioPlex200 System. Results: By the 16th week of therapy, a positive treatment response (PASI ≥ 75) was observed in 51 patients (63%), while 30 patients (37%) showed no response (PASI ≤ 50). When using etanercept, a positive effect was observed in 11 patients (41%), in 14 patients (52%) using adalimumab, and in 26 patients (96%) using infliximab. Analysis of the baseline cytokine levels revealed no differences between the “positive effect” and “no effect” groups, except for IL20, which was 2.61 times higher in the “positive effect” group compared to the “no effect” group, suggesting its potential predictive role in the effectiveness of therapy with TNFα inhibitors. Treatment led to a decrease in IL17F, IL31, sCD40L, and VEGF for all patients, and in IL20 for the “positive effect” group. The increase in ICAM1 in the “no effect” group suggests the possible retention of active migration and the fixation of T cells in the affected skin in these patients. No significant difference in cytokine levels was observed when categorizing patients into subgroups based on the effectiveness of therapy with etanercept, infliximab, and adalimumab; only a pre- and post-treatment difference in the whole cohort was noted. A random forest model showed the importance of VEGF, sCD40L, and ICAM1. Conclusions: The baseline levels of VEGF, sCD40L, and ICAM1, as well as IL20, could serve as potential predictors of treatment effectiveness using TNFa inhibitors. However, this hypothesis requires confirmation with a larger patient population.
Characteristics of Marine Heatwaves in the Southeastern Baltic Sea Based on Long-Term In Situ and Satellite Observations
Authors: Dabulevičienė Toma , Servaitė Inesa
Published: July 2024

Marine heatwaves (MHWs) are known to pose a threat to aquatic ecosystems and coastal communities and, as a result, they receive significant attention nowadays, thus motivating our scientific interest in better understanding the regional patterns of these events. In this study, we analyze MHWs in the SE part of the Baltic Sea, defining them as anomalously warm water events, where the water temperature exceeds the 90th percentile threshold of the corresponding calendar day for at least five or more consecutive days. Our study is based on a combination of long-term (1993–2023) in situ data, field measurements, and satellite-derived sea surface temperature data during the warm (May–August) period. Study results suggest that although short-lived (5–9 days) MHW events typically dominate throughout the analyzed period, the occurrences of longer (more than three weeks) and more intense MHWs have increased in our study region in the recent decade. The heatwaves are observed both in coastal and open waters, with SST anomalies up to around 5–6 °C above the 90th percentile threshold during extreme events, extending thermal influence as deep as 20 m during prolonged and more intense events. We believe that the results of this study contribute to a better understanding of MHW patterns in the study region, which is important from an ecological and socio-economic point of view, providing valuable insights for human health aspects as well.
YOLO-Based 3D Perception for UVMS Grasping
Authors: Chen Yanhu , Zhao Fuqiang , Ling Yucheng , Zhang Suohang
Published: July 2024

This study develops a YOLO (You Only Look Once)-based 3D perception algorithm for UVMS (Underwater Vehicle-Manipulator Systems) for precise object detection and localization, crucial for enhanced grasping tasks. The object detection algorithm, YOLOv5s-CS, integrates an enhanced YOLOv5s model with C3SE attention and SPPFCSPC feature fusion, optimized for precise detection and two-dimensional localization in underwater environments with sparse features. Distance measurement is further improved by refining the SGBM (Semi-Global Block Matching) algorithm with Census transform and subpixel interpolation. Ablation studies highlight the YOLOv5s-CS model’s enhanced performance, with a 3.5% increase in mAP and a 6.4% rise in F1 score over the base YOLOv5s, and a 2.1% mAP improvement with 15% faster execution than YOLOv8s. Implemented on a UVMS, the algorithm successfully conducted pool grasping experiments, proving its applicability for autonomous underwater robotics.
Mega Ports’ Mitigation Response and Adaptation to Climate Change
Authors: Puig Martí , Cirera Arnau , Wooldridge Chris , Sakellariadou Fani , Darbra Rosa Mari
Published: July 2024

Mega ports, defined in this study as those handling over 5 million TEUs annually, are major hubs within the dynamic framework of global trade, influencing both economic and environmental landscapes. This study identifies climate change as the foremost environmental concern for these ports, necessitating urgent and strategic responses. Through comprehensive research, this paper explores the main Climate Change Mitigation (CCM) strategies and evaluates their implementation across mega ports worldwide. Findings indicate widespread adoption of certain strategies, such as setting greenhouse gas (GHG) reduction targets and providing on-shore power supply (OPS), while also identifying challenges, particularly in implementing environmentally differentiated port fees. Additionally, this paper outlines key strategies for climate change adaptation (CCA) in ports. The results of this research offer insights into sustainable practices and collaborative efforts to confront climate change challenges effectively. These findings have the potential to significantly improve maritime policy and ship management strategies.
Preliminary Bioactivity Assessment of Myrothecium Species (Stachybotryaceae) Crude Extracts against Aedes aegypti (Diptera: Culicidae): A First Approach from This Phytopathogenic Fungi
Authors: Granados-Echegoyen Carlos , Campos-Ruiz José Abimael , Pérez-Pacheco Rafael , Vásquez-López Alfonso , Vera-Reyes Ileana , Arroyo-Balán Fabián , Santillán-Fernández Alberto , Villanueva-Sánchez Evert , Villanueva-Verduzco Clemente , Fonseca-Muñoz Alicia , Diego-Nava Fidel , Wang Yi
Published: July 2024

Mosquitoes, as insect vectors, play a crucial role in transmitting viruses and parasites, leading to millions of human deaths in tropical and subtropical regions worldwide. This study aimed to evaluate the effects of ethanolic extracts of three species within the genus Myrothecium (M. roridum, M. dimerum, and M. nivale) on Aedes aegypti mosquito larvae to assess the inhibitory effect on growth and development, as well as to determine mortality. We quantify the average lethal concentrations and provide a qualitative characterization of the chemical groups responsible for their potential. Phytochemical screening revealed the presence of alkaloids, flavonoids, and terpenoids in the ethanolic extracts of the three fungal species. Tannins were found only in the extracts of M. dimerum and M. roridum. We observed a clear dependence of the effects of the crude extracts on mosquito larvae on the concentrations used and the duration of exposure. The toxic effect was observed after 48 h at a concentration of 800 ppm for both M. dimerum and M. nivale, while M. roridum showed effectiveness after 72 h. All three species within the genus Myrothecium exhibited 100% biological activity after 72 h of exposure at 600 ppm. At lower concentrations, there was moderate growth and development inhibitory activity in the insect life cycle. The study highlights the effectiveness of crude Myrothecium extracts in combating mosquito larvae, with effects becoming apparent between 48 and 72 h of exposure. This initial approach underscores the potential of the fungus’s secondary metabolites for further in-depth analysis of their individual effects or synergies between them.
Diagnosis of Anxiety in COPD Patients: Usefulness of the HADS Test in Primary Care and Pulmonology Services
Authors: Barrueco Enrique , Hernández-Mezquita Miguel A. , Hidalgo-Sierra Vanesa , Cordovilla Rosa , Olivera-Pueyo Javier , Galán Javier
Published: July 2024

Anxiety disorders, characterized by excessive fear and anxiety, are increasingly recognized as significant comorbidities in chronic diseases such as chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the prevalence of anxiety in COPD patients referred from primary care centers to pulmonology services and to identify predictive factors for anxiety. This was a multicentric, observational, and prospective study in which 293 COPD patients were recruited, and they underwent comprehensive respiratory and smoking histories, spirometry, and anxiety assessments using the Hospital Anxiety and Depression Scale (HADS). The results showed a diagnosis of suspected anxiety in 85 patients (29.0%): 17 possible and 68 with a strong suspicion. The study found significant associations between anxiety and factors such as gender (women had a risk that was 3.5 times higher than men), weight, and body mass index (BMI). Disease severity, smoking status, and clinical manifestations did not significantly influence anxiety prevalence. These findings underscore the need for systematic psychological evaluations in COPD management and support the use of simple diagnostic tools like the HADS to facilitate referrals to mental health services. Addressing anxiety in COPD patients could potentially improve their quality of life and disease outcomes. This study highlights the importance of a multidisciplinary approach involving family medicine, pulmonology, and psychiatry to optimize COPD patient care and suggests that future research should focus on the impact of anxiety treatment on COPD progression. These insights call for integrating psychological assessments into routine clinical practice for comprehensive COPD management. The registration number is 10.14201/gredos.148549.
Mastery of Listening and Reading Vocabulary Levels in Relation to CEFR: Insights into Student Admissions and English as a Medium of Instruction
Authors: Li Zhiqing , Li Janis Zhiyou , Zhang Xiaofang , Reynolds Barry Lee
Published: July 2024

Prior to enrolling in an English as a medium of instruction (EMI) institution, students must show an English proficiency level through meeting a benchmark on a standard English proficiency test, which is typically aligned with the Common European Framework of Reference for Languages (CEFR). Along with overall English proficiency, aural/written vocabulary level mastery could also predict students’ success at EMI institutions, as students need adequate English vocabulary knowledge to comprehend lectures and course readings. However, aural/written vocabulary level mastery has yet to be clearly benchmarked to CEFR levels. Therefore, this study aimed to investigate the correlations between students’ aural/written vocabulary level mastery and their CEFR levels. Forty undergraduate students in a Macau EMI university were recruited to take one English proficiency test and two vocabulary level tests (i.e., Listening Vocabulary Levels Test (LVLT) and the Updated Vocabulary Levels Test (UVLT)). Correlation analyses were conducted to explore the relationship between students’ CEFR levels and their mastery of listening and reading vocabulary levels. A positive correlation was found between students’ CEFR levels and their mastery of receptive aural vocabulary levels (ρ = 0.409, p = 0.009). Furthermore, a statistically significant positive correlation was found between students’ CEFR levels and their mastery of receptive written vocabulary levels (ρ = 0.559, p < 0.001). Although positive correlations were observed, no clear pattern was identified regarding the relationship between students’ CEFR levels and their mastery of aural/written vocabulary levels. Regression analyses were further conducted to determine the extent to which the combination of receptive aural and written vocabulary knowledge predicts the CEFR levels. The results indicated that the regression model that included only UVLT scores better predicted the CEFR levels. Given the positive correlations observed between students’ CEFR levels and their mastery of vocabulary levels, this study’s findings suggest the inclusion of aural/written vocabulary levels as additional indicators for ensuring student academic success in EMI institutions. Implications for EMI universities on student admissions, classroom teaching, and provision of additional English courses were provided.
Integrated Optimization of Production Scheduling and Haulage Route Planning in Open-Pit Mines
Authors: Xu Changyou , Chen Gang , Lu Huabo , Zhang Qiuxia , Liu Zhengke , Bian Jing
Published: July 2024

In mining, deposits are divided into blocks, forming the basis for open-pit mine planning, covering production and haulage route planning. Current studies often stage optimization and lack the consideration of road capacity, leading to suboptimal solutions. A novel approach integrates production scheduling and haulage route planning through a bilevel optimization model. The upper-level model integrates ore mining constraints to establish a mixed-integer production scheduling model, minimizing haulage costs. Spatiotemporal correlation constraints for block mining are determined using a two-stage algorithm. The lower-level model incorporates road capacity, forming a haulage route optimization model based on multicommodity network flow. A solution algorithm with a distance penalty strategy facilitates feedback between the upper and lower levels, achieving optimal solutions. Tested on a real open-pit coal mine with over 5 million blocks, this approach reduces haulage costs by 10.06% compared to stage optimization. Additionally, this approach allows for adjusting haulage demand in both temporal and spatial dimensions, effectively preventing road congestion. This study advances rational mining processes and enhances the efficiency of open-pit mining haulage systems.
Trajectory Optimization for Adaptive Deformed Wheels to Overcome Steps Using an Improved Hybrid Genetic Algorithm and an Adaptive Particle Swarm Optimization
Authors: Liu Yanjie , Wei Yanlong , Wang Chao , Wu Heng
Published: July 2024

Two-wheeled mobile robots with deformed wheels face low stability when climbing steps, and their success rate in overcoming steps is affected by the trajectory. To address these challenges, we propose an improved hybrid genetic and adaptive particle swarm optimization (HGAPSO) algorithm to optimize the deformed wheels’ trajectory for overcoming steps. HGAPSO optimizes the maximum and minimum values of the inertial weight and learning factors of the adaptive particle swarm algorithm utilizing the region-wide search capabilities of the genetic algorithm, which substantially improves the convergence speed and adaptability. Furthermore, the analysis of the motion of the deformed wheel overcoming the steps and the examination of the potential interference during the operation are used to construct a wheel’s center-of-mass route based on fifth-order Bézier curves. Comparative simulation experiments of the trajectories optimized using different optimization algorithms under the same working conditions are designed to demonstrate the efficacy of the proposed HGAPSO algorithm in optimizing the trajectory of the deformed wheel overcoming the step. Simulation experiments were conducted using the HGAPSO algorithm to optimize the trajectories of deformation wheels for overcoming steps of various sizes. These optimized trajectories were then compared to unoptimized ones. The results showed that the HGAPSO-optimized trajectories significantly improved the success rate and stability of the mobile robot in overcoming steps.
Quantitative Microstructure Prediction of Powder High-Temperature Alloy during Solution Heat Treatment and Its Validation
Authors: Liu Zhaofeng , Cheng Junyi , Wang Chao , Guo Jianzheng
Published: July 2024

Heat treatment, particularly solution heat treatment, is a critical process in the preparation of powder metallurgy superalloys, where the cooling process significantly impacts the microstructure. This study, based on thermodynamic and kinetic databases as well as the precipitation mechanism of strengthening phases, delves into the influence of cooling process, especially the cooling path, on the material’s microstructure. The results indicate that under slow cooling rates, the precipitated phases are more likely to exhibit a multimodal size distribution, while under rapid cooling rates, a unimodal distribution may form. The average cooling rate does not consistently accurately reflect the growth of the precipitated phases; even with the same average cooling rate, different cooling paths can lead to significant differences in the size of the precipitates. To accurately predict the size of the precipitates, it is necessary to consider the specific cooling process. Constant cooling rate experiments designed for the study and the dissection testing of full-size turbine discs produced in manufacturing validated the calculated results of the precipitates. Therefore, optimizing cooling through simulation calculations can effectively and accurately control the precipitates, thereby obtaining a microstructure that can meet performance requirements.
Correlation between Thermodynamic Studies and Experimental Process for Roasting Cobalt-Bearing Pyrite
Authors: Urtnasan Erdenebold , Kumar Avneesh , Wang Jei-Pil
Published: July 2024

Cobalt is a critical metal widely distributed in nature, but cobalt ore has hardly been found as an independent mineral. Cobalt-bearing pyrite tailings separated from iron ore is one of the resources for recovering cobalt. In the following study, roasting is carried out to oxidize cobalt-bearing pyrite tailings for preparing and recovering the cobalt by acid leaching. The further aim of the research is to determine and control the optimal technological regime for roasting by using thermodynamic modeling. The phase transition in Fe–S–O and Co–S–O systems and its mechanism are analyzed under the partial pressure of oxygen and sulfur dioxide at constant temperatures. Thermodynamic modeling proves that iron and cobalt sulfides can be intensively oxidized at a relatively high temperature (>900 °C) under an atmosphere of logp(O2) > −5, leading to the formation of SO2 (logp(SO2) < 0). The results of the roasting experiment indicate 98% desulfurization degree upon holding for about 4–5 h and at > 1000 °C. Based on these thermodynamic modeling and experimental results, the roasting of cobalt containing pyrite can be optimized with substantial productivity with regard to the metal oxide and cobalt thereof. Oxidative roasting also allows the elimination of environmentally hazardous gases such as sulfur during the process.
Wide-Temperature Characteristics of Additively PBF-LB/M Processed Material Ti6Al4V
Authors: Dvorak Karel , Dvorakova Jana , Majtas Dusan , Sevcik Radek , Zarybnicka Lucie
Published: July 2024

Titanium-based alloys are a widely applicable engineering material with high strength, low weight, non-magnetic, and corrosion resistance. At the same time, resistance to low temperatures is declared, which offers the material’s applicability for, e.g., aircraft or ship technology. Additive technologies are part of the industrial spectrum of material processing, especially the Laser Powder Bed Fusion of Metals method for metal alloys, which creates a layered structure of the resulting body. The topology of the internal structure, in relation to the temperature history of the functional environment, influences thermal expansion and the associated functional characteristics. Knowledge of the thermal expansion of printed strength and non-strength functional components and accessories is essential for future applications, especially in environments with high repeatable temperature changes, such as the aerospace industry. This paper presents the results of testing the expansion, mechanical, microstructural, and mineralogical characteristics of Ti6Al4V over the temperature range of −70 to 60 °C using a combination of instrumental techniques such as X-ray diffraction and nanoindentation. It was found that the topological orientations of the printed samples directly influenced the tested properties, e.g., the coefficient of thermal expansion in the direction perpendicular to the printed layers showed approximately 12% lower value compared to the other directions. Due to the progression of the application of the manufacturing method and its applicability within selected industries, the research provides results in a new area, which is supported by the relevant research.
Biogenic Calcium Carbonate: Phase Conversion in Aqueous Suspensions
Authors: Espinosa-Acosta Brian , Breen Jake J. , Burchell Meghan , Poduska Kristin M.
Published: July 2024

Powdered biogenic calcium carbonate from butter clams shows variations in its tendency to convert from aragonite to calcite when suspended in water, depending on whether the suspension has additional calcite or not. Our investigations treat these biogenic samples as complex hierarchical materials, considering both their mineral and organic components. We assess the mineral composition from Attenuated Total Reflection Fourier Transform Infrared spectroscopy peak shifts, as well as quantitative assessments of lattice constant refinements (powder X-ray diffraction). To isolate the mineral portions, we compare results from samples where the periostracum is removed mechanically and samples that are heated to temperatures that are sufficient to remove organic material but well below the temperature for thermal phase conversion from aragonite to calcite. The results show that the total organic content does not play a significant role in the aqueous mineral phase conversion. These results have potential implications for understanding carbonate mineral interactions in ocean sediments.
Differential Characteristics of Conjugate Strike-Slip Faults and Their Controls on Fracture-Cave Reservoirs in the Halahatang Area of the Northern Tarim Basin, NW China
Authors: Wang Shenglei , Chen Lixin , Su Zhou , Dong Hongqi , Ma Bingshan , Zhao Bin , Lu Zhendong , Zhang Meng
Published: July 2024

The X-type strike-slip fault system and weathering crust karst fracture-cave and channel reservoirs were developed in the Halahatang area of the northern Tarim Basin. However, the relationship between the reservoir and the strike-slip fault remains controversial. Based on the core data, and taking an NE-striking strike-slip fault as an example, this paper dissects the karst reservoir from wells along the strike-slip fault damage zone and analyzes the control of scales, properties, and segmentation styles of strike-slip faults on karst reservoirs. The results show that (1) the scale of the strike-slip fault controls the distribution of the reservoir—the wider the fault damage zone, the wider the fracture-cave reservoirs; (2) the transtensional segments of the strike-slip fault are more likely to produce karstification, and the buried-hill area and the interbedded area are controlled by different hydrodynamic conditions to form different types of karst reservoirs; (3) six different parts of the strike-slip fault are conducive to the formation scale of fault fracture zones. This research provides new insight into recognizing karst reservoirs within strike-slip fault damage zones, which can be further applied to predict karst reservoirs controlled by strike-slip faults.
Can Graph Machines Accurately Estimate 13C NMR Chemical Shifts of Benzenic Compounds?
Authors: Duprat François , Ploix Jean-Luc , Dreyfus Gérard
Published: July 2024

In the organic laboratory, the 13C nuclear magnetic resonance (NMR) spectrum of a newly synthesized compound remains an essential step in elucidating its structure. For the chemist, the interpretation of such a spectrum, which is a set of chemical-shift values, is made easier if he/she has a tool capable of predicting with sufficient accuracy the carbon-shift values from the structure he/she intends to prepare. As there are few open-source methods for accurately estimating this property, we applied our graph-machine approach to build models capable of predicting the chemical shifts of carbons. For this study, we focused on benzene compounds, building an optimized model derived from training a database of 10,577 chemical shifts originating from 2026 structures that contain up to ten types of non-carbon atoms, namely H, O, N, S, P, Si, and halogens. It provides a training root-mean-squared relative error (RMSRE) of 0.5%, i.e., a root-mean-squared error (RMSE) of 0.6 ppm, and a mean absolute error (MAE) of 0.4 ppm for estimating the chemical shifts of the 10k carbons. The predictive capability of the graph-machine model is also compared with that of three commercial packages on a dataset of 171 original benzenic structures (1012 chemical shifts). The graph-machine model proves to be very efficient in predicting chemical shifts, with an RMSE of 0.9 ppm, and compares favorably with the RMSEs of 3.4, 1.8, and 1.9 ppm computed with the ChemDraw v. 23.1.1.3, ACD v. 11.01, and MestReNova v. 15.0.1-35756 packages respectively. Finally, a Docker-based tool is proposed to predict the carbon chemical shifts of benzenic compounds solely from their SMILES codes.
A Comprehensive Analysis of Fel Ursi and Its Common Adulterants Based on UHPLC-QTOF-MSE and Chemometrics
Authors: Wang Xianrui , Wu Haonan , Li Minghua , Guo Xiaohan , Cheng Xianlong , Jing Wenguang , Wei Feng
Published: July 2024

Background: As one of the four most valuable animal medicines, Fel Ursi, named Xiong Dan (XD) in China, has the effect of clearing heat, calming the liver, and brightening the eyes. However, due to the special source of XD and its high price, other animals’ bile is often sold as XD or mixed with XD on the market, seriously affecting its clinical efficacy and consumers’ rights and interests. In order to realize identification and adulteration analysis of XD, UHPLC-QTOF-MSE and multivariate statistical analysis were used to explore the differences in XD and six other animals’ bile. Methods: XD, pig gall (Zhu Dan, ZD), cow gall (Niu Dan, ND), rabbit gallbladder (Tu Dan, TD), duck gall (Yan Dan, YD), sheep gall (Yang Dan, YND), and chicken gall (Ji Dan, JD) were analyzed by UHPLC-QTOF-MSE, and the MS data, combined with multivariate analysis methods, were used to distinguish between them. Meanwhile, the potential chemical composition markers that contribute to their differences were further explored. Results: The results showed that XD and six other animals’ bile can be distinguished from each other obviously, with 27 ions with VIP > 1.0. We preliminarily identified 10 different bile acid-like components in XD and the other animals’ bile with significant differences (p < 0.01) and VIP > 1.0, such as tauroursodeoxycholic acid, Glycohyodeoxycholic acid, and Glycodeoxycholic acid. Conclusions: The developed method was efficient and rapid in accurately distinguishing between XD and six other animals’ bile. Based on the obtained chemical composition markers, it is beneficial to strengthen quality control for bile medicines.
Formation and Reactions of Brønsted and Lewis Acid Adducts with Electron-Rich Heteroaromatic Compounds
Authors: Hartmann Horst , Liebscher Jürgen
Published: July 2024

Electron-rich heteroaromatics, such as furan, thiophene and pyrrole, as well as their benzo-condensed derivatives, are of great interest as components of natural products and as starting substances for various products including high-tech materials. Although their reactions with Brønsted and Lewis acids play important roles, in particular as the primary step of various transformations, they are often disregarded and mechanistically not understood. The present publication gives a first overview about this chemistry focusing on the parent compounds. It comprises reactions with strong Brønsted acids forming adducts that can undergo intramolecular proton and/or substituent transfer reactions, ring openings or ring transformations into other heterocycles, depending on their structure. Interactions with weak Brønsted acids usually initiate oligomerizations/polymerizations. A similar behaviour is observed in reactions of these heteroaromatics with Lewis acids. Special effects are achieved when the Lewis acids are activated through primary protonation. Deuterated Brønsted acids allow straight forward deuteration of electron-rich heteroaromatics. Mercury salts as extremely weak Lewis acids cause direct metalation in a straight forward way replacing ring H-atoms yielding organomercury heterocycles. This review will provide comprehensive information about the chemistry of adducts of such heterocycles with Brønsted and Lewis acids enabling chemists to understand the mechanisms and the potential of this field and to apply the findings in future syntheses.
Overview of Hepatitis B Vaccine Non-Response and Associated B Cell Amnesia: A Scoping Review
Authors: Bello Nura , Hudu Shuaibu A. , Alshrari Ahmed S. , Imam Mustapha U. , Jimoh Abdulgafar O.
Published: July 2024

Background: The advent of the hepatitis B vaccine has achieved tremendous success in eradicating and reducing the burden of hepatitis B infection, which is the main culprit for hepatocellular carcinoma—one of the most fatal malignancies globally. Response to the vaccine is achieved in about 90–95% of healthy individuals and up to only 50% in immunocompromised patients. This review aimed to provide an overview of hepatitis B vaccine non-response, the mechanisms involved, B cell amnesia, and strategies to overcome it. Methods: Databases, including Google Scholar, PubMed, Scopus, Cochrane, and ClinicalTrials.org, were used to search and retrieve articles using keywords on hepatitis B vaccine non-response and B cell amnesia. The PRISMA guideline was followed in identifying studies, screening, selection, and reporting of findings. Results: A total of 133 studies on hepatitis B vaccine non-response, mechanisms, and prevention/management strategies were included in the review after screening and final selection. Factors responsible for hepatitis B vaccine non-response were found to include genetic, immunological factors, and B cell amnesia in healthy individuals. The genetic factors were sex, HLA haplotypes, and genetic polymorphisms in immune response markers (cytokines). Non-response was common in conditions of immunodeficiency, such as renal failure, haemodialysis, celiac disease, inflammatory bowel disease, hepatitis C co-infection, and latent hepatitis B infection. Others included diabetes mellitus and HIV infection. The mechanisms involved were impaired immune response by suppression of response (T helper cells) or induced suppression of response (through regulatory B and T cells). Discussion: A comprehensive and careful understanding of the patient factors and the nature of the vaccine contributes to developing effective preventive measures. These include revaccination or booster dose, vaccine administration through the intradermal route, and the use of adjuvants in the vaccine.
Zika Virus Neuropathogenesis—Research and Understanding
Authors: Metzler Anna D. , Tang Hengli
Published: July 2024

Zika virus (ZIKV), a mosquito-borne flavivirus, is prominently associated with microcephaly in babies born to infected mothers as well as Guillain-Barré Syndrome in adults. Each cell type infected by ZIKV—neuronal cells (radial glial cells, neuronal progenitor cells, astrocytes, microglia cells, and glioblastoma stem cells) and non-neuronal cells (primary fibroblasts, epidermal keratinocytes, dendritic cells, monocytes, macrophages, and Sertoli cells)—displays its own characteristic changes to their cell physiology and has various impacts on disease. Here, we provide an in-depth review of the ZIKV life cycle and its cellular targets, and discuss the current knowledge of how infections cause neuropathologies, as well as what approaches researchers are currently taking to further advance such knowledge. A key aspect of ZIKV neuropathogenesis is virus-induced neuronal apoptosis via numerous mechanisms including cell cycle dysregulation, mitochondrial fragmentation, ER stress, and the unfolded protein response. These, in turn, result in the activation of p53-mediated intrinsic cell death pathways. A full spectrum of infection models including stem cells and co-cultures, transwells to simulate blood–tissue barriers, brain-region-specific organoids, and animal models have been developed for ZIKV research.
Polarization-Dependent Formation of Extremely Compressed Femtosecond Wave Packets and Supercontinuum Generation in Fused Silica
Authors: Geints Ilia , Kosareva Olga
Published: July 2024

Previous studies of formation of extremely compressed wave packets during femtosecond filamentation in the region of anomalous group velocity dispersion in solid dielectrics mostly considered the case of linearly polarized laser pulses. However, recent results suggest potential applications of polarization state manipulation for ultrafast laser writing of optical structures in bulk solid-state media. In the present work, evolution of radiation polarization parameters during formation of such extreme wave packets at the pump wavelength of 1900 nm in fused silica is studied numerically on the basis of the carrier-resolved unidirectional pulse propagation equation (UPPE). It was revealed that initial close-to-circular polarization leads to higher intensity of the anti-Stokes wing in the spectrum of the generated supercontinuum. Numerical simulations indicate a complex, space–time variant polarization state, and the resulting spatiotemporal electric field distribution exhibits a strong dependence on the initial polarization of the femtosecond pulse. At the same time, electric field polarization tends to linear one in the region with the highest field strength regardless of the initial parameters. The origin of this behavior is attributed to the properties of the supercontinuum components generation during filament-induced plasma formation.
Fast 2D Subpixel Displacement Estimation
Authors: Wan Min , Healy John J. , Sheridan John T.
Published: July 2024

Fast and simple methods for motion estimation with subpixel accuracy are of interest in a variety of applications. In this paper, we extend a recently proposed method for quantifying 1D displacements with subpixel accuracy, referred to as the subtraction method (SM) to 2D motion. Simulation and experimental results are presented. The results indicate that any general motion in 2D involving combinations of in-plane motions in x and y can be determined using SM after a 1D calibration. The errors between the actual motion and estimated are examined.