bluuebunny/crossref_metadata_2025 huggingface dataset:
A Large Paraganglioma Neck – Managed Successfully by Transcervical Excision
Authors: Jha Rakesh Kumar , Dutta Angshuman , Gupta Anshul Prakash , Dwivedi Surjeet Kumar
Published: May 2024

Glomus vagale paraganglioma is a slow-growing, benign, and relatively uncommon tumor, accounting for < 3% of head-and-neck paragangliomas. It predominantly arises from vagal nodose ganglion in the carotid sheath and mostly comprises extraadrenal nonchromaffin cells. It usually presents as an asymptomatic cervical mass but rarely can present with local compressive symptoms. Mostly paragangliomas are nonfunctional, however, functional paraganglioma needs to be ruled out by clinical examination (such as tachycardia, hypertension, and facial flushing) and laboratory investigation like vanillylmandelic acid in urine and serum. It also needs to be differentiated from other neck masses, for example, carotid body tumor, carotid aneurysm, nerve sheath tumor, etc., Imaging modalities such as ultrasonography, contrast-enhanced computed tomography or magnetic resonance imaging are required to characterize and diagnose such neck lesions and ascertain their relationship with the neck vessels. Surgical excision is considered the mainstay of treatment which mandates segmental resection of the vagus nerve and results in significant postoperative morbidity. We hereby report a case of 53-year-old female with a large, highly vascular glomus vagale tumor in the neck which was densely adherent to neck vessels (common carotid artery/internal carotid artery/external carotid artery and internal jugular vein) and presented with local compressive symptoms. The patient was successfully managed by preoperative angioembolization followed by transcervical excision of the tumor.
Effect of Zebularine on Apoptotic Pathways in Hepatocellular Carcinoma Cell Lines
Authors: Sanaei Masumeh , Kavoosi Fraidoon
Published: May 2024

Background:

The alteration of DNA cytosine methylation is one of the most common epigenetic changes that can play a significant role in human cancers. The enzymes involved in DNA methylation of promoter regions of the genes are DNA methyltransferases (DNMTs). The therapeutic activities and apoptotic effects of DNA methyltransferase inhibitors (DNMTIs) have been reported in various cancers. This study was assigned to assess the effect of zebularine on intrinsic and extrinsic pathways, DNAT 1, 3a, and 3b, p21, and p53, viability, and apoptosis in hepatocellular carcinoma (HCC) cell lines.

Methods:

Hepatocellular carcinoma cell lines (HCCLM3, MHCC97H, and MHCC97L) were purchased from the National Cell Bank of Iran, Pasteur Institute, treated with zebularine, and the MTT assay was performed. Then, flow cytometry assay and real-time RT-PCR analysis were performed with zebularine. Statistical comparisons between groups were made using GraphPad Prism software version 8.0. A significant difference was considered as P < 0.05.

Results:

Zebularine up-regulated DR4, DR5, FAS, FAS-L, TRAIL, Bax, Bak, Bim, p21WAF/CIP1 (p21), and p53 and down-regulated DNMTs (DNAT 1, 3a, and 3b), Bcl-2, Bcl-xL, and Mcl-1, significantly resulting in apoptosis induction in HCC cell lines. Maximal and minimal apoptosis was seen in HCCLM3 and MHCC97L cell lines, respectively.

Conclusions:

Our findings indicated that DNMTI zebularine can induce apoptosis and inhibit cell growth through both pathways (extrinsic and intrinsic) in HCC cell lines HCCLM3, MHCC97H, and MHCC97L.
Dietary Supplement Use among Iranian Households during COVID-19 Epidemic Lockdown: Less Access in Those Who May Need More National Food and Nutrition Surveillance
Authors: Ghodsi Delaram , Nikooyeh Bahareh , Amini Maryam , Rabiei Samira , Doustmohammadian Azam , Abdollahi Zahra , Minaie Mina , Sadeghi Farzaneh , Clark Cain C. T. , Neyestani Tirang R. , Rasekhi Hamid
Published: May 2024

Background:

The coronavirus disease 2019 (COVID-19) pandemic elicited the general population to use various dietary supplements (DSs) and nutraceuticals as a protective means against the disease. The present study aimed to evaluate changes and certain determinants of DS intake during the COVID-19 lockdown among Iranian households.

Methods:

This nationwide cross-sectional study was conducted from April 4 to April 25, 2020, during which Iran was in lockdown. To collect data, a web-based electronic self-administered questionnaire was created. The data were compared among provinces based on their food security situations.

Results:

A total of 21,290 households were included in the analyses. Approximately 27% of the households were using DSs after the epidemic. The most common DSs used were vitamin D (42%) and vitamin C (20%), followed by multi-vitamin (16%), zinc (9%), omega-3 (6%), vitamin A (4%), and probiotics (3%). Logistic regression analysis revealed that DS intake was directly associated with the household income but inversely with household size and the food security status of the provinces. DS intake was positively associated with the presence of high-risk persons in the households, the education of the households' head, and the presence of a person with a history of COVID-19 within the household.

Conclusions:

During epidemic lockdown, DS use was remarkably increased among the Iranian households. Apart from the debatable usefulness of DSs against COVID-19, the inverse association of DS use with a household's income and provincial food security well indicates inequity in accessibility to DS. Actions to improve the nutritional status of the under-privileged populations including targeted supplementation are strongly recommended.
Presentation, Management and Early Mortality of Patients with Acute Coronary Syndrome in a Large Sample Study of a Middle East Country
Authors: Bahrani Saeide , Sadeghi Masoumeh , Teimouri-jervekani Zahra , Nouri Fatemeh , Sarrafzadegan Nizal
Published: May 2024

Background:

Due to lack of contemporary data on the presentation, management, and mortality of acute coronary syndrome (ACS) admissions in Iran, in this prospective registry study, we aimed to evaluate the presentation, management, and mortality as the outcome of patients with ACS in Isfahan, Iran, 2001–2016 to address treatment and healthcare depletions.

Methods:

Data of 62,276 patients admitted with the diagnosis of ACS from 2001 to 2016 prospectively were obtained by Surveillance Unit of Isfahan Cardiovascular Research Center, Isfahan, Iran, in 13 hospitals of Isfahan province. We evaluated data on presentation, management, and in-hospital and 28-day mortality.

Results:

Nearly half of the patients ranged in age from 51 to 70 years (32050, 51.5%), which did not differ among ACS types (ST-segment myocardial infarction (STEMI): 53.9%; non-STEMI: 53.4%; unstable angina: 51.9%). In-hospital, anti-platelets use was high (84.9%). Thrombolytic were used in 48.1% of STEMI, 3.8% of non-STEMI, and 1.1% of unstable angina. Discharge medication rates were suboptimal. In-hospital and 28-day mortality were highest for STEMI (6.5 and 12.6%, respectively).

Conclusions:

These data represent the large ACS registry in Iran. Data revealed the various presentations of ACS and demonstrated opportunities for improving ACS management by focusing on increasing use of recommended drugs especially after discharge due to suboptimal medical treatment in these patients. The high mortality rate needs to be taken into consideration in ACS patients.
The Therapeutic Impact of Garlic (Allium Sativum) on Oxidative Stress Markers among Polycystic Ovary Syndrome Patients: A Randomized, Double-Blinded Clinical Trial
Authors: Zadhoush Roya , Alavi-Naeini Amirmansour , Feizi Awat , Naghshineh Elham , Ghazvini Mohammad Reza
Published: May 2024

Background:

The present study aimed to investigate the effect of garlic supplementation on oxidative stress markers in patients with polycystic ovary syndrome (PCOS).

Methods:

Eighty patients with PCOS were randomized and instructed to consume either garlic supplementation (800 mg/day) or a placebo (starch) for 8 weeks. They were also asked to avoid intake of any other supplement during the study. Oxidative stress-related markers including total antioxidant capacity, catalase, glutathione, malondialdehyde concentrations, and anthropometric measures were assessed at baseline and end of the trial.

Results:

Garlic supplementation resulted in significant improvement in catalase concentration (1.82 ± 9.28 vs. –1.55 ± 8.66; P value: 0.03), glutathione levels (29.15 ± 57.53 vs. 2.42 ± 77.51; P value: 0.048) as well as weight (–0.64 ± 1.94 vs. 0.11 ± 0.82; P value: 0.04), body mass index (BMI; –0.25 ± 0.75 vs. 0.05 ± 0.61; P value: 0.04), and waist circumference (–0.21 ± 0.77 vs. 0.02 ± 0.65; P value: 0.01). However, we failed to detect any significant change in hip circumference, waist to hip circumference ratio, total antioxidant capacity, and malondialdehyde levels between the two groups.

Conclusions:

The present study indicates that garlic supplementation could be beneficial in improving oxidative stress and weight loss among PCOS women.
Challenges of Rural Family Physician Policy in Iran
Authors: Shams Lida , Nasiri Taha , Amiri Mohamad M. , Abdolahi Zohreh
Published: May 2024

As per the goals of the family physician program, it is essential to pay attention to the effectiveness and performance of FPP. Although the implementation of the FPP program is an important development in the discussion of rural health insurance and the provision of health services and referral systems in the country, the evidence suggests that by identifying challenges and taking appropriate action, this plan can be improved. This study aimed to investigate the challenges of rural Family Physician Policy (FPP) in northern Iran. This study comprised a mixed method. The former intended to identify the challenges of rural FFP using the narrative review method. To achieve a comprehensive list of challenges, a narrative review and content analysis were performed and semi-structured interviews were held with key stakeholders of FPP in the north of Iran, including physicians, managers, and policymakers. Identified challenges were categorized into eight categories including the weakness of the health insurance system, low comprehensiveness of executive guidelines, inappropriate recruitment and maintenance of human resources, weakness of cultural context, low efficacy of health information management system, poor educational effectiveness, inappropriate motivational mechanisms, and weakness of the referral system. As per the quantitative findings, “weakness of the referral system” and “inappropriate recruitment and maintenance of human resources” had the lowest and highest weaknesses, respectively. To address existing challenges in the rural FPP, a comprehensive plan of action should be developed with an emphasis on human resource management, health information management system, comprehensive rural health insurance, and legislation.
Urtica Dioica (Gazaneh) Distillate Restores Glucose Metabolism in Diabetic Rats
Authors: Zamani-Garmsiri Fahimeh , Akmali Masoumeh , Gohari Ali , Zal Fatemeh , Seghatoleslam Atefeh
Published: May 2024

Background:

Diabetes has become an important health problem in the world. Natural agents, with antidiabetic property, are potential candidates for improving diabetes. Urtica Dioica Distillate (UDD) or Araghe Gazaneh is widely used for the treatment of diabetes as per traditional medicine. Despite the tremendous use of UDD as an antidiabetic compound in folk medicine, the antidiabetic effects of UDD has been neglected by medical scientists. In this study, we aimed to evaluate the effects of UDD on the glucose metabolism in diabetic rats.

Methods:

A total of 24 male rats were divided equally into four groups, two treatment and two control groups, each containing normal or Streptozotocin (STZ)–induced diabetic rats. During 4 weeks, control and treatment rats received water or UDD, respectively. Fasting blood sugar (FBS), HbA1c, serum creatinine, blood urea nitrogen, and specific activities of hepatic enzymes including glucokinase (GK), hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), and muscle glucose transporter type 4 (GLUT4) and liver phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels were measured.

Results:

FBS and HbA1c increased in diabetic groups. Treatment with UDD significantly lowered FBS and prevented weight loss. Decreased FBS level was associated with higher activity levels of GK and HK in UDD-treated diabetic rats. G6PD-specific activity decreased in diabetic control rats compared to nondiabetic ones, but UDD treatment improved it to the normal levels. A significant decrease in the expression level of GLUT4 was observed in diabetic control rats compared to nondiabetic ones, but UDD increased it to the normal levels.

Conclusions:

These findings suggest that UDD might exert therapeutic effects against diabetes by improving glucose metabolism and can be used as an alternative or complementary medicine for the treatment of diabetic patients.
Hypothyroidism in First-Degree Relatives of Neonates with Congenital Hypothyroidism: Is there an Association?
Authors: Heidarpour Maryam , Omoomi Sepehr , Vakilbashi Omid , Taki Azin , Hovsepian Silva
Published: May 2024

Background:

Recent studies have shown an increased incidence of congenital hypothyroidism (CH), especially in the middle-east region. The exact etiology is unknown; however, it has been related to several factors, the most noticeable being the high prevalence of transient CH (TCH), parental consanguinity, and the history of hypothyroidism in relatives. We sought to determine the impact of hypothyroidism in the relatives of patients with the observed trend.

Methods:

We included all patients with primary CH detected through the Newborn Screening (NBS) Program from 2007 to 2016. We analyzed the impact of consanguinity relationship, parental and siblings' thyroid function, second-degree relatives' thyroid function, parental educational level, age, and maternal gestational diabetes on the development of permanent CH (PCH) and TCH.

Results:

A total of 1447 consecutive eligible patients were recruited during the study period. Of this number, 1171 (81%) were diagnosed with CH: 623 (53.2%) had PCH and 548 (46.8%) had TCH. Six hundred thirty-three (54.1%) participants were men, and 814 (69.5%) had a history of relatives' hypothyroidism. Our data analysis revealed a significant difference regarding the male gender, having a history of relatives' hypothyroidism, and parental hypothyroidism compared to TCH ones (P < 0.05). Patients with a history of relatives' hypothyroidism had significantly higher PCH than TCH (P < 0.0001). However, consanguineous marriage was not comparable in patients regardless of their history of relatives' hypothyroidism (P-value >0.884).

Conclusions:

Our findings indicated the role of the history of hypothyroidism in neonates' relatives in the evolution of the PCH. Meanwhile, consanguineous marriage did not impress the development of PCH and TCH.
The Prevalence of Inflammatory Bowel Disease (IBD) in Patients with Multiple Sclerosis (MS): A Systematic Review and Meta-Analysis
Authors: Nasirzadeh Amirreza , Jahanshahi Reza , Ghajarzadeh Mahsa , Mohammadi Aida , Moghadasi Abdorreza Naser
Published: May 2024

Background:

This systematic review and meta-analysis aim to update the pooled prevalence of Inflammatory bowel disease (IBD) in patients with multiple sclerosis (MS).

Methods:

Two researchers independently and systematically searched PubMed, Scopus, EMBASE, Web of Science, and google scholar. They also searched for references of the included studies, and conference abstracts that were published up to September 2021.

Results:

The literature search revealed 5719 articles, after deleting duplicates 3616 remained. Finally, 17 studies were included. The pooled prevalence of IBD in MS was 1% (I2 = 96.3%, P < 0.001). The pooled odds ratio of developing IBD in MS cases was 1.36 (95% CI: 1.1–1.6) (I2 = 58.3, P = 0.01).

Conclusions:

The results of this systematic review and meta-analysis show that the pooled prevalence of IBD in MS patients was 1% and the pooled odds ratio of developing IBD in MS cases was 1.36.
Using Data Mining Techniques to Predict Chronic Kidney Disease: A Review Study
Authors: Sattari Mohammad , Mohammadi Maryam
Published: May 2024

One of the growing global health problems is chronic kidney disease (CKD). Early diagnosis, control, and management of chronic kidney disease are very important. This study considers articles published in English between 2016 and 2021 that use classification methods to predict kidney disease. Data mining models play a vital role in predicting disease. Through our study, data mining techniques of support vector machine, Naive Bayes, and k-nearest neighbor had the highest frequency. After that, random forest, neural network, and decision tree were the most common data mining techniques. Among the risk factors associated with chronic kidney disease, respectively, risk factors of albumin, age, red blood cells, pus cells, and serum creatinine had the highest frequency in these studies. The highest number of best yields was allocated to random forest technique. Reviewing larger databases in the field of kidney disease can help to better analyze the disease and ensure the risk factors extracted.
What Do We Need to Start a Multimedia Salt Reduction campaign?
Authors: Pouraram Hamed , Afshani Farideh , Ladaninejad Maryam , Siassi Fereydoun
Published: May 2024

As reports of the first national study reveal, Iranian salt intake reaches 9.52 g/day (two times more than recommended by World Health Organization). Meanwhile ignoring the consequences of high salt intake has led to an increased rate of cardiovascular diseases (CVD), stroke, stomach cancer, osteoporosis, obesity, etc., To tackle these threatening issues, a nationwide intervention campaign could be an effective solution based on global experiences. A review of previous work in Iran shows that despite numerous efforts conducted in the prevention of CVDs, they were not well reflected in worldwide sources. Furthermore, a comprehensive campaign was not implemented particularly concerning the salt reduction in Iran. As a result, we first reviewed the major successful initiatives conducted in reducing salt intake around the world and Iran. Then we introduced the components of a comprehensive social marketing campaign along with customized actions related to Iranian nutrition habits, their attitude, and behavior toward salt consumption. These employed components were SWOT analysis, identifying target group, determining communication goals and objectives based on models and theories, planning executive plan, designing communication messages and materials, media planning and promotional actions, and determining campaign budget plus monitoring and evaluation.
Non-Pharmacological Infection Prevention and Control Interventions in COVID-19
Authors: Shankar P. Ravi , Palaian Subish , Vannal Venkataramana , Sreeramareddy Chandrashekhar T.
Published: May 2024

Coronavirus disease-19 (COVID-19), a major global public health emergency has significantly impacted human health and livelihoods. The pandemic continues to spread and treatments and vaccines are at different stages of development. Mass vaccination has been rolled out worldwide. This review article provides a narrative summary of the evidence on various non-pharmacological interventions (NPIs) for COVID-19 containment. The authors reviewed the evidence published by the Norwegian Institute of Public Health map of COVID-19 evidence. Additional literature was identified from PubMed and Google Scholar, preprint sites, and news media. The search terms included “Social distancing measures” and “COVID 19”, “Non-pharmacological interventions” and “COVID 19”, “COVID-19”, “non-pharmacological interventions”, “face mask”, etc. The strength of the evidence for most studies on NPIs was ‘weak to moderate’ for restrictive NPIs. Ascertaining the impact of each NPI as a standalone intervention is difficult since NPIs are implemented simultaneously with other measures. Varying testing and reporting strategies across the countries and classification of deaths directly caused by COVID-19 create challenges in assessing the impact of restrictive NPIs on the case numbers and deaths. Evidence on hygiene measures such as face mask is more robust in design providing credible evidence on prevention of COVID-19 infection. Evidence from modeling studies, natural before-after studies, and anecdotal evidence from the strategies adopted by ‘role model’ countries suggests that continued use of NPIs is the only containment strategy until ‘herd immunity’ is achieved to reduce the severe disease and mortality.
A Rare Anatomical Variant: Aberrant Arterial Supply of Azygoesophageal Recess Originating from the Celiac Plexus
Authors: Doğan Emrah , Doğan Marwa Mouline , Güney Bünyamin , Tapan Özge Oral , Tapan Utku , Olcay Sabri Serhan
Published: May 2024

The aberrant arteries of the lung are very rare abnormalities. It is included in the type 1 sequestration group when it is a single finding without other sequestration features. Sequestrations account for <1% of all lung malformations. Type 1 is the least common form in this group. In 75% of these cases, the aberrant artery (AA) originates from the thoracic aorta. AA originating from the celiac plexus is very rare. Moreover, even if it originates from an abdominal vascular, AA is extended left lower lobe of the lung or the right middle lobe. Our case is atypical with its azygoesophageal recess (AOR) localization. The AOR is a special region that forms the mediobasal segment of the right lung. After the pandemic, this region has been expressed as one of the areas where COVID-19 infection shows affinity. The reason for this condition has not been definitively clarified yet. Therefore, the anatomical details of this segment need to be more probed. Furthermore, the radiological multidetector computed tomography (MDCT) appearance of our case is in the differential diagnosis, with Scimitar syndrome and, as far as we know, this differential diagnosis detail has not been mentioned so far. MDCT plays an important role in the diagnosis and planning of definitive treatment by determining the origin and course of the AA. Definitive treatment may be surgery (lobectomy or segmentectomy) or endovascular. The case of a 62-year-old patient with a lung AA is presented accompanied by radiological and clinical findings.
Electron Microscopic Observation of Normal and 2,4,5-Trihydroxyl Phenylethylamine (6-hydroxydopamine) Lesioned Corpus Striatum in Wistar Albino Rats
Authors: Ravisankar P , Ravishankar P , Ravindran R , Sridevi G , Mathew J
Published: May 2024

Background:

The prevalence and incidence of Parkinson’s disease (PD) is increasing due to a prolonged life expectancy. The cardinal features of PD include resting tremor, rigidity, bradykinesia, and postural instability. In rodents the 2,4,5-trihydroxyphenylethylamine [6-hydroxydopamine (6-OHDA)] induced lesion of the nigrostriatal system showed retrograde degeneration and structural changes in the corpus striatum under transmission the electron microscope (TEM).

Aim and Objectives:

To study the ultra-structure of normal and 6-OHDA lesioned corpus striatum in Wistar albino rats under the transmission electron microscope.

Material and Methods:

Wistar albino male adult rats received unilateral stereotaxical injection of 6-OHDA on the right side of striatum and were sacrificed after 120 days. The following stereotaxic co-ordinates were used to target the dorsolateral part of the striatum: AP = 0.2 mm, ML = 3.2 mm, DV = 4.5 mm from the bregma. Another target was the dorsomedial part of striatum: AP = 1.1 mm, ML = 2.4 mm and DV = 3.5 mm.The motor behavior was monitored in cylinder which was counted for a period of 60 min.

Results and Conclusion:

Our TEM finding in the control rats demonstrated that nucleus was round and comparatively large in proportion to the cell body and lies in the centre of the nerve cell in the striatum. Occasionally one or two dense nucleoli were located eccentrically in the nucleoplasm. Additionally, in the cytoplasm around the nucleus, the conspicuous organelles along with the numerous ribosomes which were mostly free and appear as rosettes or clusters, some of which were attached to the endoplasmic reticulum. Furthermore, few short of granular endoplasmic reticula were seen. Interestingly, the lesioned rats showed neuronal and glial cells damage at the ultra-structural level in striatum under TEM observation.
Correlation of Body Mass Index with Ankle Joint Range of Motion in Young Adults
Authors: Rohatgi Rachna , Bhatnagar Aditi , Gupta Nirupma , Jain Manjari
Published: May 2024

Introduction:

The body mass index (BMI) together with gender and age widely affect the movements of joints of the individual. The increments in the magnitude of weight of body have a detrimental impact on the interaction of joints and muscles which have a long-term impact on balance and posture of the individual. The posture and balance is compromised to a great extent by the reduction of joints of the lower limb.

Objectives:

To calculate the BMI, range of motion (ROM) of ankle joints in both flexed and extended knee positions bilaterally and to correlate the effects of BMI on the ROM of ankle joint.

Materials and Methods:

The Department of Anatomy, School of Medical Sciences and Research, Sharda University, Greater Noida was the place of this cross-sectional study in which 235 subjects (108 males and 127 females) in the age group of 18–25 years participated voluntarily.

Results:

One-way ANOVA analysis of bilateral values of ankle dorsiflexion with flexed and extended knee of both sides revealed a statistically significant difference with a progressive decrease in the values from normal to obese group.

Conclusion:

The findings of the present study could prove useful for designing rehabilitative interventions for the overweight and obese subjects with the aim to improve their activities of daily living and reduce the morbidity from increased body mass.
Unilateral Sweating: A Case Study of Localized Unilateral Hyperhidrosis
Authors: Vaid Zubin
Published: May 2024

ABSTRACT

Localized unilateral hyperhidrosis (LUH) is a rare disorder with intense sweating in a specific area, often without common triggers. This study details a 32-year-old man with activity-induced unilateral sweating. Comprehensive tests ruled out serious conditions. This unique case adds to the limited reports of LUH in healthy individuals.
The Effect of Sticky Bone with Concentrated Growth Factor on Bone on Socket Preservation and Delayed Implant Placement: A Case Report of Two Cases
Authors: Sitamahalakshmi K , Bingi Sai Krishna , Mandhrachalam Radhika , Sai S Keerthi
Published: May 2024

ABSTRACT

As they release and enhance numerous areas for regeneration signaling and maintenance, platelets are energy sources with a wealth of growth factors (GFs). To create sticky bone (SB), concentrated GF (CGF), one of the platelet generations, was combined with a bone transplant. The purpose of this study was to determine how concentrated SB development affects bone density and volume surrounding dental implants. Two patients with grossly decayed tooth or grade III mobile tooth were included in the study. After extraction of the tooth, SB enriched with CGF was placed in the socket and closed with membrane. After 1 month of socket preservation, dental implantation is performed. Loading of implant is performed after 3 months of implant placement. Bone volume and density measurements were performed immediately after socket preservation (T0), 1 month after socket preservation after implant placement (T1), and 3 months after socket preservation loading of dental implants (T2) with cone-beam computed tomography (CBCT). Bone volume and density increased 3 months after socket preservation loading of dental implant (T2) when compared to baseline that is immediately after socket preservation (T0) and 1 month of socket preservation after implant placement (T1). Also, improvement is seen after 1 month of socket preservation. It was observed that SB with CGF shows excellent enhancement in bone formation in quality and quantity of the bone after socket preservation and loading of implant compared with CGF alone.
Optimizing IVF Success: A Case Study of Melatonin-Assisted Frozen Embryo Transfer for Poor Oocyte Quality and Endometriosis
Authors: Dakre Sudanshu M. , More Akash , Shrivastava Jarul , Choudhary Namrata , Khemani Shivani , Ulhe Shradha , Bondare Radha , Dutta Shilpa
Published: May 2024

ABSTRACT

The case study investigates the journey of a couple facing infertility. It intensifies the challenges, including poor oocyte quality and endometriosis. In spite of two failed in vitro fertilization cycles, the decision for ovum pickup (OPU) was made, followed by intra-cytoplasmic sperm injection (ICSI), embryo treatment with melatonin, and frozen embryo transfer (FET) to optimize the chances of a successful pregnancy. The couple opted for this approach. OPU yielded four poor-quality oocytes, prompting ICSI and melatonin treatment to enhance embryo quality. The embryos were exposed to culture supplementation with melatonin for 72 hours before being transferred to conventional media. After 5 days or 120 hours, the embryos developed into 3BB quality blastocysts, indicative of developmental stage and morphology. The blastocysts were then cryopreserved, and after 2 months, FET was conducted, resulting in the transfer of two embryos, which subsequently led to a positive pregnancy indication, as indicated by a β-hCG level of 233 mUI/ml measured 14 days post transfer. This approach highlights the effectiveness of melatonin supplementation in improving embryo quality and ultimately facilitating successful pregnancy in complex scenarios like endometriosis-related infertility.
Effect of Platelet-Rich Plasma (PRP) in Combination with Endometrial Scratching for Patients Undergoing Assisted Reproductive Technology Treatment
Authors: Kadu Krushnali S. , More Akash , Shrivastava Jarul , Gajabe Gauri , Dagwar Prerana , Chaudhary Namrata , Jadhav Ritesh
Published: May 2024

ABSTRACT

Endometrium scratching is a process of intentionally injuring the endometrium, and after scratching the endometrium, platelet-rich plasma (PRP) is inserted into the endometrial wall to improve pregnancy outcome. This case report revolves around a 33-year-old woman and her 38-year-old husband, who have been married for 3 years and were seeking treatment for their secondary infertility. The female had a history of hypothyroidism, and after the investigation, she was diagnosed with hyperprolactinemia. She also had a history of failure in vitro fertilization (IVF) cycles and two recurrent miscarriages upon investigation. The husband was found to have asthanozoospermia. After diagnosis of the female, we started treatment of cabergoline for hyperprolactinemia, a history of unsuccessful IVF cycles, and two recurrent miscarriages upon investigation. After the treatment of hyperprolactinemia in our clinic, we scheduled ovum pick-up and started the stimulation and performed intra-cytoplasmic sperm injection. After 1 month, we scheduled embryo transfer. On day 1, the progesterone scratched the endometrium wall and loaded the PRP to enhance the endometrial wall, and after an interval of 14 days, we checked the β-hCG level in the blood, and the result was positive, that is, the level was 1020 mIU/mL. The successful result of endometrial scratching with PRP improves pregnancy outcomes.
A comprehensive review of biopsy techniques for oculoplastic and orbital surgeons from ophthalmic pathologists’ perspective
Authors: Alkatan Hind M. , Alyousef Nada A. , Alshabib Norah S. , Aljasser Ibrahim H.J.
Published: May 2024

This narrative review aims to discuss different modalities for obtaining diagnostic orbital biopsies, compares the available updated methods, and provides recommendations on the choice of technique. It also highlights special precautions in the handling of orbital specimens from various pathologies. A search was performed in PubMed and Google Scholar with no language or study type restriction. The keywords orbital biopsy, core biopsy, fine-needle aspiration biopsy, and orbit were used, and titles and abstracts were screened for relevance.
Controversies in Management of Localized Prostate Cancer: Before and After Radical Local Therapy
Authors: Ghosh Joydeep , Ghose Amit
Published: May 2024

The therapeutic world of prostate cancer has evolved a lot in the last decade. Initially, we have only androgen deprivation therapies, earlier generation androgen receptor pathway inhibitor (ARPI), and chemotherapy. Now, we have multiple other options, and also there are ample data in all the spaces of its management. However, some areas need discussion, as controversies exist. In this review, we would like to throw some light on such controversial real in dealing with the biochemical recurrence after radical local therapy (RLT) and neoadjuvant treatment before RLT. We envisage to clear the cloud as per the existing literature.
Progress of Traditional Chinese Medicine Treating COVID-19
Authors: Li Ming-Xue , Yang Yue-Ying , Liu Yang , Zheng Meng-Zhu , Li Jun , Chen Li-Xia , Li Hua
Published: May 2024

The new coronavirus pneumonia (coronavirus disease 2019 [COVID-19]), caused by the new coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), mainly manifests by fever, dry cough, and fatigue. The emergence of SARS-CoV-2 poses a huge threat to people's lives. Unfortunately, so far, there are no effective treatment drugs and vaccines. Traditional Chinese medicine (TCM) has played an important role and achieved good results for treating this epidemic. More than 85% of patients with SARS-CoV-2 infection in China have received TCM treatment. In this article, we describe the progress of TCM for the COVID-19 therapy.
Experimental assessment of the efficacy of copper ion treatment against penicillin G contained in UHT milk and PBS
Authors: Ulloa Fernando , Villegas Marcela , Tejeda C Carlos , Salgado Miguel
Published: May 2024

Antibiotics are widely used in animal production to treat bacterial infections and to improve performance and animal welfare. Their misuse poses a threat to public and animal health because of the possible development of antibiotic-resistant microorganisms. Among the many strategies that have been considered to address this problem are methods to degrade antibiotic residues, especially those from the human and animal food chain. This study describes the effect of copper ion treatment on the detection of penicillin G in a liquid matrix. An in vitro experimental study was designed using both commercial milk and PBS spiked with three different concentrations of penicillin G. Each sample was treated for 30 min with copper ions. All samples were tested for antibiotics before and after treatment using a commercial enzyme-linked receptor binding assay. Additionally, pH, copper concentration, and temperature were evaluated. Antibiotic residues were detected in all spiked PBS and milk samples before treatment with copper ions. However, after 30 min of treatment, no antibiotic residues were detected in any sample at any concentration tested. In conclusion, treatment of penicillin-contaminated milk and PBS samples with copper ions affects antibiotic detection, which would potentially reduce antibiotic levels.
О выборочной оценке энтропии Реньи конечных вероятностных схем
Authors: Selivanov Boris Ivanovich
Published: May 2024

В работе рассматривается $\alpha$-энтропия конечных вероятностных схем, предложенная А. Реньи в 1961 году в качестве их мер неопределенности (случайности). Представлены две новые предельные теоремы для выборочной оценки энтропии Реньи последовательности независимых полиномиальных испытаний.
Nghiên cứu đánh giá các đặc tính sinh học của gel Ibuprofen
Authors: Lan Lê Thị Thanh , Anh Đoàn Nhựt Mai
Published: May 2024

Ibuprofen là một hoạt chất chống viêm không steroid (NSAID) điển hình, thường được sử dụng để điều trị đau, viêm và sốt từ nhẹ đến trung bình. Tuy nhiên, việc sử dụng ibuprofen thông qua đường uống trong thời gian dài đối với các bệnh mãn tính như viêm khớp có thể gây ra một số tác dụng phụ không mong muốn ở mức độ nghiêm trọng, trong đó có loét dạ dày. Do đó, công thức gel bôi ngoài da chứa 5% ibuprofen đã được nghiên cứu và phát triển để giải quyết vấn đề trên. Bài viết này tập trung trình bày các kết quả đánh giá gel ibuprofen nói trên. Theo đó, căn cứ các hướng dẫn được đề cập trong ISO 10993:2009 (ISO, 2015), gel ibuprofen được cung cấp không có khả năng gây độc đối với nguyên bào sợi chuột L-929 và nguyên bào sợi người hF. Bên cạnh đó, gel ibuprofen cũng có khả năng dàn trải đồng đều, khả năng phóng thích hoạt chất ra khỏi chế phẩm đạt hơn 90% trong 05 giờ và có khả năng thẩm thấu qua da chuột. Hướng nghiên cứu này có thể được tiếp tục phát triển với một số nội dung nghiên cứu như đánh giá khả năng thấm của hoạt chất qua da người, thử nghiệm mức độ kích ứng, đánh giá độ ổn định.
Középiskolás diákok énhatékonyságának vizsgálata
Authors: Zagyváné Szűcs Ida
Published: May 2024

Az élethosszig történő tanulás feltétele az önszabályozott tanulásra való képesség. Az oktatási folyamatban a pedagógus alapvető feladata a tanulók önszabályozott tanulásának fejlesztése. A tanulmány egy nagyobb kutatás részkutatásának eredményeit mutatja be. A longitudinális vizsgálat során az általunk tanított középiskolás diákok énhatékonyságának alakulását helyeztük a középpontba. Kutatási célunk az volt, hogy feltárjuk, az angol nyelv tanulása során végzett rendszeres önértékelés eredményeként változott-e, és ha igen, akkor milyen mértékben a tanulók énhatékonyságának észlelése. Kutatásunk akciókutatás, amelynek során lehetőségünk volt összehasonlítani kísérleti csoportunk eredményeit egy kontrollcsoportéval. Eredményeink bizonyára hozzájárulnak kutatótanári programunk gazdagításához, amelynek fő célja az önszabályozott tanulás fejlesztési lehetőségeinek feltérképezése az önértékelés egy bizonyos módszerének (rubrics) segítségével.
Pataki és Makarenko
Authors: K. Nagy Emese , Pető Ildikó
Published: May 2024

Az írás célja annak a bemutatása, hogy Makarenko hogyan jelenik meg Pataki Ferenc műveiben. Bemutatjuk, hogy Pataki Makarenko elméleti és gyakorlati munkáját hogyan elemezte úgy, hogy rámutatott a pedagógiai tevékenységben a közösségre és az egyénre ható bonyolult szociálpszichológiai hatásmechanizmusokra. Kiemelt figyelmet fordítunk az egyén és a közösség kapcsolatának az értékelésére, valamint Pataki és Makarenko pedagógiáról vallott nézetei mellett kitérünk Pataki politikai érzékenységére is. Célunk annak felvázolása, hogy miért tartjuk ma Magyarországon Patakit (szinte) az egyedüli Makarenko-ismerőnek.
A térbeli jövedelemegyenlőtlenségek változása Magyarországon
Authors: Tánczos Tamás , Csugány Julianna , Egri Zoltán
Published: May 2024

A társadalmi és gazdasági fejlettség, illetve az azzal szorosan összefüggő jövedelmi kondíciók térbeli különbségeinek vizsgálata évtizedek óta foglalkoztatja a hazai kutatókat. A területi egyenlőtlenségek változásának időbeli alakulása mérhető a vizsgált időszak első évére jellemző állapot és a vizsgált időszak egészére jellemző tendencia összevetésével, azaz béta konvergenciával, illetve történhet szóródás és szórás alapú mutatók, azaz szigma konvergencia segítségével. A szóródás és szórás alapú mérőszámok a területi egyenlőtlenségek mértékét és annak időbeli változását abszolút és relatív megközelítésben is képesek jellemezni. Tanulmányunk célja, hogy különböző egyenlőtlenségi mutatók és megközelítések mentén feltárjuk a hazai járások közötti jövedelemegyenlőtlenség alakulását 1992 és 2020 között, és rámutassunk az egyes mérőszámok alapján kapott eredmények közötti összefüggésekre, illetve különbségekre, kitérve az összefüggések és különbségek okaira is.
A rejtett és a tranzakciós költségek szerepe a fenntarthatóságban
Authors: Szlávik János , Csáfor Hajnalka
Published: May 2024

Írásunk abból a feltételezésből, sőt előfeltételekből indul ki, hogy a fenntarthatóság felé való elmozdulás, a fenntarthatósági célok megvalósulása a közjó erősödését, a társadalmi jólét (jóllét) javulását szolgálja. Hiábavaló azonban bármely jó szándék és pozitívnak tűnő cselekvés, ha a költségek és hasznok rejtve maradnak a gazdasági és társadalmi folyamatokban. Ezért elemezzük a rejtett, majd tranzakciós költségeket. (Ez utóbbi esetében kiemelve R. Coase Nobel-díjas közgazdász gondolatait.) A fenntarthatóság szempontjából erősen vitatható, ha csak a Pigou-féle megoldásokkal összhangban túlzottan a kormányzati megoldásokat alkalmazzák a pici kudarcok csökkentésére. A piaci kudarcok mellett ugyanis egyre erősebben jelennek meg a kormányzati kudarcok. A rejtett költségek rejtve maradnak, a tranzakciós költségek pedig a csökkenés helyett nőnek.
A 2008-as gazdasági világválság és a 2020-as koronavírus-járvány hatásai Magyarország és az Európai Unió idegenforgalmának teljesítőképességére
Authors: Gyurkó Ádám
Published: May 2024

Magyarország és az Európai Unió turisztikai mutatói jelentős változásokon mentek keresztül 2004 és 2022 között, mely változások egymástól eltérő jellegűek voltak. Amennyiben a turisztikai mutatókat pusztán a bázisév (2004) és a tárgyév (2022) szerint vizsgáljuk, akkor dinamikus növekedésről beszélhetünk, de a köztes időszakokban a növekedés dinamikája nem volt egyenletes, sőt stagnáló vagy erősen csökkenő időszakok is azonosíthatók voltak. Ezek a negatív folyamatok főként a 2008-as pénzügyi világválság és a 2020-as koronavírus-járvány hatására kibontakozó gazdasági visszaesés időszakaiban voltak megfigyelhetők. Az Európai Unió gyakorlatilag egészében és így Magyarországon is 2004 és 2008 között még növekedés volt tapasztalható a forgalmi mutatókban, ami hazánk esetében általános gazdasági növekedésének és az integrációhoz való csatlakozásának köszönhető. Ezt a növekedést a 2008-ban kibontakozó pénzügyi válság törte meg, amely végül gazdasági világválsággá duzzadt, mely több éven át negatív hatással volt a turizmus teljesítőképességére. A recesszióból való kilábalás egyértelmű jelei az általános és a turisztikai GDP-ben egyaránt 2011-től voltak tapasztalhatók az EU egészében, bár hazánk esetében az idegenforgalom dinamikus felfutása inkább 2012-re datálható. A válságból való kilábalás után a turizmus szektor soha nem tapasztalt bővülésen esett át hazai és nemzetközi szinten egyaránt. A bővülés mértéke már olyan ütemű volt, hogy a kutatók törvényszerű bezuhanást vizionáltak, ami végül be is következett. Azonban a bezuhanás nem törvényszerű mechanizmusok hatására bontakozott ki, hanem a 2020-ban világviszonylatban is megjelenő koronavírus-járvány következtében bevezetett jogi korlátozások hatására. A válságos időszakok ellenére a turizmus szektor a XXI. században már nemzetgazdasági szinten is meghatározó iparágként definiálható még olyan országokban is, mint Magyarország, amelyet nemzetközi hatású vonzerők, tengerpartok és magashegységek híjján nem nevezhetünk egy turisztikai nagyhatalomnak. Jelen tanulmány rávilágított arra, hogy a legnagyobb válságok idején a jogi és egzisztenciális keretek csökkenésének ellenére sem törik meg az utazások iránti hajlandóság, sőt a válságos időszakok elmúlásával kijelenthető, hogy törvényszerű a turizmus teljesítőképességének dinamikus felfutása. Ezért szükségszerű a válságos, a köztes és a poszt időszakok teljesítményértékelésének modellezése és elemzése, melyet jelen értekezés szerzője Magyarország és az Európai Unió vonatkozásában vizsgált. Napjainkban – többek között – a koronavírus hatásaként jelentkező nagymértékű infláció komoly ágazati, strukturális problémákat vethet fel a turizmus területén is, melynek eredményeképpen bizonyos társadalmi rétegek kiszorulhatnak egyes szolgáltatások igénybevételéből.
Examining the European Transition: Central Eastern European Countries Two Decades post-EU Accession
Authors: Wozniak-Jechorek Beata
Published: May 2024

The year 2024 is particularly noteworthy as it marks the 20th anniversary of the European Union's most significant expansion, with ten countries joining the EU. This paper aims to examine the current stage of economic transformation in these 11 Central and Eastern European (CEE) countries, 20 years after their accession, and to identify the sources of their success. The study assesses the initial conditions at the time of EU accession for countries such as the Czech Republic, Poland, Slovakia, Hungary, Estonia, Lithuania, Latvia, and Slovenia in 2004, followed by Bulgaria and Romania in 2007, and Croatia in 2013. It then analyzes the economic perspectives two decades post-accession, summarizing the recent growth drivers. Over the past two decades, the CEE-EU bloc has achieved remarkable GDP growth rates and social progress, demonstrating the effectiveness of structural reforms, both political and economic, integration into the European single market and global value chains, as well as openness and a willingness to learn from others.
Mindfulness, perfectionism, and professional burnout among specialists in the information technology field
Authors: РАКУ Жанна , МУНТЯН Ирина
Published: May 2024

This article examines the relationship between mindfulness and socially prescribed perfectionism with professional burnout among specialists in the information technology field in Moldova, with an emphasis on age and gender differences. The research group consisted of 120 IT professionals: 58% male and 42% female. The analysis showed that there is a significant negative correlation between mindfulness and professional burnout (correlation coefficient -0.649), indicating a decrease in burnout risk with increased levels of mindfulness. At the same time, socially prescribed perfectionism enhances professional burnout, with a positive correlation of 0.391, especially among young men. These results highlight the need to consider psychological factors when developing corporate well-being strategies.
Evaluation of the psychological intervention program applied to people with drug-resistant epilepsy
Authors: DOȚEN Natalia
Published: May 2024

Drug-resistant epilepsy presents a myriad of psychological challenges, including cognitive decline, emotional and behavioral disturbances, loss of autonomy, stigma, psychosocial dysfunction, and a heightened risk of trauma and premature death, all of which significantly diminish the quality of life. This article aims to identify effective strategies for working with individuals affected by drug-resistant epilepsy and to develop a targeted psychological intervention program tailored to their unique needs. Six subjects diagnosed with drug-resistant epilepsy participated in this program. The results revealed significant improvements across multiple do mains following the intervention. There were notable enhancements in general cognitive functioning, reductions in levels of depression and anxiety, and decreases in aggressive and hostile behaviors. These positive outcomes collectively contributed to an overall increase in the quality of life for individuals grappling with drug-resistant epilepsy.
Distinct characteristics of eating disorder behaviors in adolescents with type 1 diabetes
Authors: CONDREA Victoria
Published: May 2024

This study examines the characteristics of eating disorders in adolescents with type 1 diabetes (T1D) compared to adolescents without T1D. Analyzing a sample of 132 adolescents with T1D and 132 without T1D, the study used the Eating Disorder Inventory (EDI-3 FT) to assess the prevalence of the drive for thinness, body dissatisfaction, and bulimic behavior. The results indicate a higher prevalence of bulimic behavior, body dissatisfaction, and drive to thinness in adolescents with T1D compared to those without. The study highlights the complexity of managing T1D and its impact on the risks of EDs, suggesting the need for integrated screening strategies and tailored psychological support. These findings contribute to a better understanding of the interaction between chronic health conditions and eating behavior, which is essential for improving therapeutic interventions and support offered to adolescents with T1D.