bluuebunny/crossref_metadata_2025 huggingface dataset:
Amaurosis fugax due to internal carotid artery dissection during carotid chemodectoma resection
Authors: Akhmedov A.D. , Lukshin V.A. , Shmigelsky A.V. , Kurbasov A.A. , Usachev D.Yu.
Published: October 2024

The article presents a clinical observation of carotid chemodectoma resection, which was complicated by amaurosis fugax and left-sided hemianopia due to dissection of internal carotid artery during surgery. The clinical symptoms manifested on 3rd day after surgery and totally resolved after internal carotid artery reconstruction also on the 3rd day. Treatment of carotid chemodectoma requires a multidisciplinary approach involving a neurosurgeon who has the skills of reconstructive operations on brachiocephalic arteries, a radiologist, and an endovascular surgeon. Determining the tactics and stages of treatment requires an individual approach, depending on the size of the tumor, the degree of invasion into the carotid arteries and cranial nerves.

В данной статье приводится описание клинического наблюдения удаления каротидной хемодектомы, ослож- нившейся развитием преходящего амавроза со стороны операции и левосторонней гемианопсии. Данное осложнение стало следствием диссекции внутренней сонной артерии (ВСА) после удаления опухоли с мани- фестацией клинических симптомов на 3-и сутки после операции. У пациента острота зрения восстановилась на 1-е сутки после операции до 1,0, гемианопсия регрессировала на 3-и сутки после реконструкции ВСА. Лечение каротидных хемодектом требует полидисциплинарного подхода с участием нейрохирурга, владею- щего навыками реконструктивных операций на брахиоцефальных артериях, радиолога, эндоваскулярного хирурга. Определение тактики и этапности лечения требует индивидуального подхода в зависимости от размеров опухоли, степени инвазии в сонные артерии и черепные нервы.
hanges in the structure of the sodium-potassium pumpin different parts of the rat brain after administration of the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxin
Authors: Korolev A.G. , Kiseleva N.M. , Inozemtsev A.N.
Published: October 2024

The variety of non-motor symptoms at the preclinical stage of Parkinson's disease makes it relevant to search for adequate and simple methods for their modeling in rodents. Subcutaneous or intraperitoneal administration of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to mice is one of the most common models of experimental parkinsonism in rodents. Intranasal administration of this neurotoxin to rats remains a less studied but promising way to induce moderate damage to brain dopaminergic neurons without causing motor symptoms in animals. Material and methods. MPTP was administered intranasally to 28 Wistar rats. After 16 days, 9 brain structures were extracted and the content of three α-subunits of Na/K-ATPase was evaluated by Western Blotting.Results. We found that a single intranasal administration of neurotoxin to rats led to a decrease in the content of α1- and α2-subunits and an increase in the content of α3-subunits of Na/K-ATPase in various parts of the rat cerebral cortex, including the olfactory bulbs. In subcortical structures, changes were found only in the striatum and hippocampus. Conclusions. The obtained data suggest a change in the functional activity of brain neurons in the structures associated with the acquisition and execution of instrumental reflexes in rats

Многообразие немоторных нарушений болезни Паркинсона на доклинической стадии развития заболевания делает актуальным поиск адекватных и простых способов их моделирования на грызунах. Подкожное или внутрибрюшинное введение нейротоксина 1-метил-4- фенил-1,2,3,6-тетрагидропиридина (МФТП) мышам является одной из наиболее распространенных моделей экспериментального паркинсо- низма на грызунах. Интраназальное введение данного нейротксина крысам остается менее изученным, но перспективным способом вызвать у животных умеренное повреждение дофаминергических нейронов головного мозга без моторной симптоматики. Материал и методы. МФТП вводили интраназально 28 крысам Wistar. Через 16 дней извлекали 9 структур головного мозга и методом Вестерн–Блоттинга оценивали содержание трех α-субъединиц Na/K-АТФазы. Результаты. Установлено, что однократное интраназальное введение нейротоксина крысам привело к снижению содержания α1- и α2- субъедениц и росту числа α3-субъедениц Na/K-ATФазы в различных отделах коры головного мозга крыс, в т.ч. в обонятельных луковицах. В подкорковых структурах изменения были выявлены только в стриатуме и гиппокампе. Выводы. Полученные данные позволяют предположить изменение функциональной активности нейронов го- ловного мозга в структурах, связанных с выработкой и воспроизведением инструментальных рефлексов у крыс.
ESIPT fluorescence turn-on sensors for detection of short chain inorganic polyphosphate in water
Authors: Roy Subhra , Moser Sandra , Dürr-Mayer Tobias , Hinkelmann Rahel , Jessen Henning
Published: October 2024

We introduce two water-soluble excited state intramolecular proton transfer (ESIPT) based fluorescent turn-on probes responding to inorganic polyphosphates. These ESIPT probes enable specific detection of short-chain inorganic polyphosphates over a range of different other condensed phosphates. The probes are weakly emissive in their off state due to the blocking of ESIPT by Cu2+ coordination. Removal of the copper ion through decomplexation by the analyte accesses the on-state. The probes detect polyphosphates over other biologically occurring phosphates, pyrophosphate, and nucleotides such as ATP, ADP, GTP. An optimal fluorescence response is observed with the short-chain polyphosphate polyP8. Furthermore, the probe shows selectivity towards linear polyphosphates over cyclic metaphosphates. The rapid ‘turn-off―turnon’ fluorescence responses upon consecutive addition of Cu2+ and polyP8 are reversible, further highlighting sensor performance in an aqueous environment. One of the sensors is then applied to monitor polyP digestion by an exopolyphosphatase (PPX).
Enhanced methanol production via selective hydrogen utilization during CO2 hydrogenation over Co containing dual-atom doped oxide catalyst
Authors: Dostagir Nazmul Hasan MD , Tomuschat Carlo Robert , Fukuoka Atsushi , Shrotri Abhijit
Published: October 2024

Capturing hydrogen with CO2 to produce methanol is becoming increasingly intriguing. Renewable H2 is expensive and is currently produced in a limited amount. Therefore, selective utilization of H2 towards methanol formation, which has been paid little attention to, is necessary without being wasted towards side product formation. Here, we show that using Co containing dual-atom doped oxide (Co-Zn-ZrO2) catalyst H2 utilization can be selectively directed towards methanol formation and at the same time, H2 wastage can be minimized by suppressing competitive CO formation. Co-Zn-ZrO2 produced methanol with space time yield of 1.5 gMeOH h-1 gcat-1, which is one of the highest ever reported under industrially relevant conditions. In this catalyst, Co was responsible for CO2 activation and formate stabilization and made Zn free of formate poisoning, which helped in easy H2 dissociation promoting formate hydrogenation to methanol. When Co was replaced with other metals (for example: Pd, Ni and Cu), H2 utilization was promoted more towards CO formation than towards methanol formation decreasing methanol selectivity. This work represents the potential of Co containing dual-atom doped oxide catalyst for selectively utilizing H2 for methanol formation while identifying the underlying factor for controlling H2 utilization towards methanol or CO formation.
Analysis of adenosine phosphonucleotides in blood by nh-PHIP
Authors: Pais Helen , Reile Indrek , Ausmees Kerti
Published: October 2024

The sensitivity of conventional NMR is limited to metabolites at mid-micromolar concentrations, however diagnostically relevant metabolites are often found at lower concentrations. nh-PHIP has shown promise for analyzing complex biological samples like urine, but adapting it to blood presents additional challenges due to its complex matrix. Herein we successfully demonstrate the use of nh-PHIP for detecting adenine phosphonucleotides in blood.
Towards industrially-relevant liquid-phase flow oxidations of secondary alcohols over spinel cobaltites
Authors: Tampieri Alberto , Romanelli Federica , Pittenauer Michael , Lederer Thomas , Föttinger Karin
Published: October 2024

Selective partial oxidation of alcohols is a straightforward synthetic pathway to access aldehydes and ketones, important building blocks for the chemical industry. The catalytic oxidation of higher secondary alcohols is challenging, which entails the need for low temperatures to preserve the selectivity or, in practice, the use of a liquid phase. In this work, we explored the applicability of Co-based spinel oxides as alternatives to noble metal-based supported catalysts for the oxidation of alcohols such as 2-butanol and 2-propanol. We developed a small-scale tri-phasic process in flow for consecutive weeks and using technical grade microporous catalysts, en route to more industrially-relevant systems, focussing on the practical aspects of the process. Co3O4, MnCo2O4, NiCo2O4, ZnCo2O4, and CoFe2O4 were synthesised by combustion and characterised by XRD, SEM, EDX, XPS, N2-physisorption and FT-IR spectroscopy. The same catalysts were tested in batch in the liquid phase to explore the impact of the reaction conditions on the reaction outcome and to rule out flow-specific effects. Gas phase reactions unveiled the different behaviour of the same catalysts in different environments, highlighting phase-specific effects such as the beneficial (liquid phase) vs inhibiting (gas phase) impact of Mn doping.
Synthesis, antiproliferative activity, and biological profiling of C-19 trityl and silyl ether andrographolide analogs in colon cancer and breast cancer cells
Authors: Gu Tiffany , Raval Rushika , Bashkin Zachary , Zhou Carina , Ko Sanghyuk , Kong Natalie , Hong Seoyeon , Bhaskara Aditya , Shah Samarth , Joshi Aditi , Thellakal Samahith , Rim Kaitlyn , Marimuthu Anushree , Venkatesan Srishti , Wang Emma , Li Sophia , Jayabalan Aditi , Tao Alice , Fang Yilin , Xia Lorelei , Chui Aidan , Shu Emily , Zhang Tracy , Chen Zhan , Njoo Edward
Published: October 2024

Andrographolide, a natural product, putatively functions through covalent inhibition of NF-κB, a transcription factor that modulates tumor survival and metastasis. Previous studies found that functionalization of the C-19 hydroxyl alters the primary mode of action from inhibition of NF-κB to the modulation of the Wnt1/β-catenin signaling pathway. Here, we synthesized a series of C-19 trityl and silyl ether analogs. MTT assays reveal cell line selectivity between colorectal and breast cancer cells, which is consistent with known mechanisms of β-catenin-driven cell proliferation in colorectal cancer cell lines. Through a TNF-α dependent NF-κB reporter assay, we observed that our analogs generally exhibit greater activity than andrographolide. Fluorescence imaging demonstrated that cells treated with andrographolide and its C-19 analogs retained similar distributions of active β-catenin, but notable differences in antiproliferative potency upon co-delivery with GSK-3β inhibitor CHIR99021 suggest several analogs have a greater dependence on β-catenin signaling for antiproliferative activity in HT-29 cells.
Anion-exchange Mediated Synthesis of Hollow 2D Layered Materials and Heterostructures: Mechanism and Room-Temperature Gas Sensing Properties
Authors: Rai Rajeev Kumar , Goyal Naveen , Sharma Deepak , Ram Ranit , Jagadish Koushik , Bhat Navakanta , Ravishankar N.
Published: October 2024

The designing of nanostructures with unique morphologies and enhanced functionalities is a cornerstone of modern materials science. Ion exchange reactions in inorganic crystals offer a versatile approach for precisely controlling the composition, morphology and properties of the materials through stepwise transformations. In this study, we report the anion exchange-mediated conversion of 2D layered material SnS2 into SnSe2, with SnS2-SnSe2 lateral heterostructures as intermediates. This transformation, driven by the disparate diffusion rates of S²⁻ and Se²⁻ ions, leads to the generation of hexagonal nanorings of SnSe2 (inaccessible by direct synthetic routes) via the Kirkendall effect. By carefully balancing the diffusion kinetics through concentration control, we also successfully synthesized continuous SnSe2 nanosheets. To elucidate the anion exchange mechanism, we conducted a comprehensive investigation using electron microscopy techniques, varying parameters such as time, precursor concentration, and reagents. Our findings revealed that the exchange process initiates at the edges of the template SnS2 nanosheets and progresses inward. Cross-sectional atomic-resolution electron microscopy of the interfaces and layer stacking in the SnS2-SnSe2 heterostructure uncovered numerous defects, attributed to ion migration and lattice mismatch, which were not detectable in planar views. Furthermore, as-synthesized materials are explored for gas-sensing applications. Our anion-exchange-derived SnS2-SnSe2 heterostructure and SnSe2 exhibited exceptional selectivity and sensitivity towards NO2 gas (response > 700%) at room temperature comparable to state-of-art sensors, significantly outperforming the pristine SnS2 material, which required elevated temperatures (150°C) for optimal response. This study underscores the potential of anion exchange as a powerful tool for designing novel nanomaterials with tailored properties and applications, particularly in the realm of gas sensing.
A ligand-assisted proximity effect allows for H2-driven copper hy-dride chemistry under mild conditions
Authors: Gorai Mahadeb , Rotering Philipp , Franzen Jonas , Dielmann Fabian , Teichert Johannes
Published: October 2024

A bifunctional copper(I)/N-heterocyclic carbene complex bearing a highly basic 2-iminopyridine subunit effects a variety of copper(I) hydride-based reductive transformations at low H2 pressure. The bifunctional catalyst allows for the first time to employ only catalytic amounts of alkoxide additive and is the copper(I) catalyst with the highest reactivity towards H2 re-ported so far. We can demonstrate that efficient alkyne semihydrogenations, conjugate reductions as well as 1,2-reductions of carbonyl compounds can be carried out at very low H2 pressure. The new protocol circumvents the need for previously required high-pressure equipment. At the same time, use of the new iminopyridine-based ligand allows for the tolerance of an unprecedented variety of functional groups in the realm of copper(I)-catalyzed hydrogenations. A possible working model featuring an iminopyridine-mediated proximity effect that coordinates the key alkoxide close to the reactive cop-per(I) center is proposed to account for the observed significant rise in reactivity. Mechanistic studies directed at support-ing this current working hypothesis are presented.
Historical aspects of the use of goat’s milk as a food product for young children: a review
Authors: Zakharova Irina N. , Pupykina Viktoria V.
Published: October 2024

Goat milk (GM) has been a valuable food product for children and adults all over the world for thousands of years and has been used as an important element of healthy nutrition and healing. The article provides information confirming the importance of GM, which is described in the studies of ancient greek and roman scientists (Hippocrates, Galen), in traditional chinese and arabic medicine (the works of Li Shizheng and Avicenna). The works of domestic and foreign scientists also show the possibility of using GM not only as an alternative to breast milk, but also as a highly effective means for strengthening health. The functional composition of GM makes it possible to create mixtures as close as possible to breast milk, which can be used as a source of nutrition for children in the absence of breastfeeding.
Generalized tuberculosis with intestinal lesion in an adolescent. Case report
Authors: Ovsyankina Elena S. , Panova Lyudmila V. , Lopatin Vladimir V.
Published: October 2024

In the two recent decades a decrease in tuberculosis (TB) incidence has been observed worldwide, according to the World Health Organization, while the incidence of extrapulmonary TB, including TB of the intestine, is growing. Generally, diagnosis of TB in children and adolescents is difficult due to its subclinical course in a significant part of patients. A special diagnostic challenge is extrapulmonary TB, including abdominal TB. Abdominal TB has entered the top five most frequent manifestations of extrapulmonary TB along with TB of the peripheral lymph nodes, urogenital TB, bone and joint TB, and TB of the central nervous system. Lack of specific clinical signs of the disease results in late diagnosis of abdominal TB. We described a case of generalized TB with intestinal lesion in an adolescent. We detected mistakes in the follow-up of the female patient with double exposure to household TB, which resulted in late diagnosis of the disease. We demonstrated the challenges in diagnosing intestinal TB under the guise of appendicitis, which led to the development of complications – spilled peritonitis and abdominal abscess. The tactics of management of the female patient at high risk for developing bowel obstruction was represented. Interdisciplinary interactions with extrapulmonary TB specialists were accented for cases of generalized TB.
Are pediatricians aware of the mysterious FPIES? Current diagnostic and treatment options. Case report
Authors: Zakharova Irina N. , Osmanov Ismail M. , Berezhnaya Irina V. , Dmitrieva Yulia A. , Maykova Irina D. , Dmitrieva Diana K. , Goncharova Ludmila V. , Scorobogatova Ekaterina V. , Radchenko Elena R.
Published: October 2024

The prevalence of food allergies continues to grow steadily, and due to certain difficulties in diagnosing allergies not associated with immunoglobulin E, some conditions are little known. Such diagnosis-challenging diseases include food protein-induced enterocolitis syndrome (FPIES), a relatively low-prevalence disease most commonly occurring in early childhood but, in some cases, affecting adults as well. The pathogenesis of FPIES has not been reliably studied. FPIES is associated with elevated serum tryptase and release of pro-inflammatory cytokines, including interleukin-17. A characteristic symptom of FPIES is uncontrollable vomiting, which is probably triggered by the serotonin secreted by enterochromaffin cells, which activates the vagus nerve and the vomiting reflex, determining a good response of vomiting relief with ondansetron, a serotonin receptor antagonist. Changes in gut microbiota composition were also reported in FPIES. FPIES can lead to severe complications such as hypovolemic shock due to the rapid progression of symptoms and rapid dehydration, which often requires hospitalization of patients with acute FPIES. The provoking factors usually include products from the "big nine" allergens: cow's milk, eggs, gluten, soy, nuts, peanuts, fish, seafood, and sesame. FPIES can be acute or chronic; the manifestations slightly differ depending on the disease form. Laboratory diagnosis is difficult due to the lack of reliable biomarkers, and the diagnosis is established clinically and confirmed with an oral provocation test. The key treatment for FPIES is to eliminate the trigger protein from the diet, and depending on the severity of the disease, some patients may be allowed to consume a heat-treated allergen. The prognosis of FPIES is favorable: tolerance to the trigger product in most cases is developed within two years. Further studies are required to clarify the pathogenesis, prevalence, and treatment methods, with prospective follow-up of patients with a history of FPIES and the analysis of concurrent and subsequent diseases, including allergic conditions. The article presents two clinical cases of children diagnosed with FPIES.
Endoscopic treatment of chronic pancreatitis in children: a retrospective study
Authors: Efremenkov Artem M. , Sokolov Yurij Y. , Solodinina Elena N. , Kirgizov Igor' V. , Zykin Aleksandr P. , Fomicheva Natalya V. , Korovin Sergey A. , Popov Maksim A.
Published: October 2024

Background. Chronic pancreatitis (CP) in children is a relatively rare polyetiological disease of the pancreas, accompanied by progressive inflammation of the parenchyma with gradual loss of its function and/or the occurrence of specific complications. Indications for a particular treatment method for a specific patient with a specific etiology and stage of CP are not clearly defined and largely depend on the experience and technical capabilities of a specific clinic. In recent years, individual centers have accumulated experience in using endoscopic methods for the treatment of CP in children, which seems very promising.
Aim. To analyze the results of our experience in endoscopic treatment of CP in children.
Materials and methods. From 2018 to June 2023, endoscopic treatment methods were used in 31 children with CP. Indications for endoscopic treatment were frequent episodes of exacerbation of pancreatitis in combination with signs of ductal hypertension with or without Wirsungolithiasis. According to etiology, patients were divided into groups: pancreatic duct anomalies, abnormal pancreaticobiliary junction (APBJ), hereditary CP, acquired duct strictures and idiopathic pancreatitis. The results were assessed by the frequency of episodes of exacerbation of pancreatitis.
Results. Endoscopic treatment failed in two patients due to: impossibility of cannulation of the main pancreatic duct in a child operated on for annular pancreas and impossibility of recanalization of posttraumatic duct stricture in the isthmus area. Early complications included post-manipulation pancreatitis (n=2; 6.4%), asymptomatic hyperenzymemia (n=5; 16.1%), stent loss (n=2; 6.4%), stent obstruction with pancreatic precipitates (n=2; 6.4%). The average follow-up period was 2.31±1.32 years. In all groups except APBJ, there was a significant decrease in exacerbation episodes with their complete absence in most patients. Ineffectiveness of endoscopic treatment was noted in one case of a combination of the complete type of divided pancreas and a pathogenic mutation of the gene SPINK1. Thus, endoscopic treatment was effective in 28 (90.3%) children in the early period and in 22 (71%) in the late period due to the return of symptoms in the APBJ group.
Conclusion. Endoscopic treatment of chronic pancreatitis in children is effective and can be recommended as first-line therapy. Endoscopic treatment of symptomatic APBJ has a temporary clinical effect.
Fecal microbiota transplantation: a step into the past or the future? A review
Authors: Zakharova Irina N. , Gostyukhina Anastasia D.
Published: October 2024

New data on the association of intestinal microbiome changes with some serious diseases raised the question of the role of the bacteria living in the intestine in maintaining human health. One way to study the composition and function of the microbiome and adjust it is fecal microbiota transplantation (FMT), which refers to the transfer of the donor's intestinal microbiota into the recipient's body to modify species diversity. Currently, FMT is included in the standards of care for relapsed and refractory types of clostridial infection in many countries. Its possible effect on the course of diseases such as inflammatory bowel disease, irritable bowel syndrome, metabolic syndrome, and some neurological and other diseases is being studied. Fecal biomaterial storage banks have been established in Europe, Asia, and the USA to facilitate donor selection, storage and delivery of the biomaterial to the recipient and simplify the control of the procedure, safety and adverse events. In Australia, a medicinal product is approved, which includes feces of specially examined and prepared donors. Despite many unresolved technological, legal and ethical issues, FMT has already been established as a promising potential treatment for many diseases.
Inelastic deformation accrued over multiple seismic cycles: Insights from an elastic-plastic slider-and-springboard model
Authors: Dublanchet Pierre , Olive Jean-Arthur
Published: October 2024

We study a toy model designed to build physical insight into the problem of slow accumulation of non-recoverable strain in fault blocks over multiple earthquake cycles. The model consists of a thin, horizontal elastic-plastic plate (springboard) in frictional contact with a vertical, rigid wall moving downward at a steady speed. Our model produces stick-slip cycles consisting of interseismic plate downwarping and coseismic plate upwarping as long as the moment of the frictional force at the contact does not exceed the maximum (purely plastic) bending moment the plate can sustain. We show that the duration of individual earthquake cycles and the spatial pattern of interseismic deflection are controlled by two stress ratios involving the peak yield stress of the plate, the frictional strength of the fault and the coseismic stress drop. We show that non-recoverable plate deflection accumulates over successive earthquake cycles if the plate’s yield strength decreases through time, causing a progressive decrease of the aforementioned stress ratios. We derive scaling relations between the rate of accumulation of inelastic deformation, the relative tectonic plate velocity, and the rate of lithospheric weakening. Our results are consistent with observations of long-term permanent deformation of natural fault regions.
The Role of Tax Officials in Mitigating Company’s Tax Obstacles
Authors: Asrindah Disa , Atmoko Alfriadi Dwi
Published: October 2024

This study aims to examine the role of tax official in mitigating the positive relation between firm’s informal payment on tax obstacle. As the general discourses in tax avoidance, regulation, and compliance, the role of tax official is still had limited attention. In this regard, the examination based on the data of 229 firms from the World Bank Enterprise Survey 2019, specifically in two countries (i.e., Estonia and Latvia) which are listed as the top two countries with the highest International Tax Competitiveness Index. Accordingly, this study found that in the country well-established tax management, firm’s informal payment is positively affecting the level of its tax obstacle, while professionality and transparency of tax official is reporting a negative effect. Interactionally, tax official is weakening the positive effect of informal payment on tax obstacle. In general, this denote and provide evidence for the important role of professional and transparent tax official in the tax management. Several discussions further been elaborated in both theoretical and practical to enrich the topic of tax management.
Modelo matemático de procesos para responder las necesidades de la industria 4.0
Authors: Ariza Gracia Miguel Angel
Published: October 2024

Actualmente, existe una brecha entre el sector académico y el empresarial, evidenciada en el incumplimiento de las necesidades de formación por competencias y habilidades relacionadas con los retos de la cuarta revolución industrial, tales como la gestión del cambio, la transición tecnológica, la automatización, la gestión de la información y la inclusión de la inteligencia artificial en los procesos empresariales. La principal causa de esta desalineación se origina en la falta de claridad sobre las necesidades asociadas a la adaptación y migración de herramientas, metodologías, técnicas, software y hardware propios de la cuarta revolución industrial en los procesos de las compañías. Esto genera una alta rotación de personal que no cuenta con las competencias necesarias para enfrentar estos desafíos, obligando a las empresas a incurrir en sobrecostos de capacitación y entrenamiento con proveedores externos al sector educativo, como casas de software, hardware y consultoras, dado que las instituciones de educación superior no forman directamente las competencias requeridas para mitigar esta brecha. Para abordar esta necesidad, se desarrolló una investigación doctoral que diseñó y puso en marcha un modelo determinístico de procesos denominado "Lean Academy". Este modelo permite clasificar las instituciones de educación superior en clústeres, según la variable de respuesta (Y) obtenida (cantidad de requisitos cumplidos de la cuarta revolución industrial), y así establecer estrategias para enfrentar estos desafíos desde las instituciones de educación superior en Colombia. Para lograr este objetivo, se utilizaron herramientas de inteligencia artificial que permitieron recolectar información de los involucrados y procesar los datos en el modelo matemático planteado. Los hallazgos evidencian las variables significativas que afectan directamente el cumplimiento de requisitos de las organizaciones en el marco de la cuarta revolución industrial y que no están siendo abordadas por las instituciones de educación superior. Se concluye que es posible modelar cuantitativamente las características complejas asociadas a las necesidades de la industria 4.0 en las organizaciones colombianas.
Educación en ingeniería, experiencia, resultados y buenas prácticas desde el caso del consultorio CDi de la facultad de minas de la Universidad Nacional de Colombia
Authors: Ruíz Castañeda Walter Lugo , Castillo Franco Valeria
Published: October 2024

Desde el primer semestre académico del año 2023, el Centro de Desarrollo e innovación (CDi) de la Facultad de Minas de la Universidad Nacional de Colombia Sede Medellín, ha venido desarrollando el Consultorio CDi, un proyecto a través del cual estudiantes de pregrado de diferentes programas de ingeniería realizan una práctica académica especial (PAE) en la cual implementan un servicio de consultoría básica para atender casos o consultas presentadas por Emprendimientos de Egresados de la UNAL, micro, pequeñas y medianas empresas (Mipymes), Entidades Sin Ánimo de Lucro (ESALES), y Organizaciones sociales o comunitarias. En este proceso los equipos de estudiantes, en su rol de consultores, son acompañados por tutores, profesores y/o egresados de la Facultad de Minas que orientan el proceso para mantener el nivel técnico de las temáticas del caso que se esté abordando, e igualmente disponen de acompañamiento permanente por parte del CDi para facilitar la adecuada implementación de cada momento del proceso de consultoría básica establecido. Con esta experiencia de aprendizaje activo, los estudiantes ponen en práctica los saberes adquiridos en su proceso de formación, al tiempo que fortalecen habilidades transversales como el trabajo en equipo y el pensamiento crítico, y aportan al fortalecimiento de las diversas organizaciones usuarias del Consultorio CDi, en aspectos como: modelo de negocio, planeación estratégica, estructuración de costos, mercadeo y ventas, gestión ambiental, gestión de la información y analítica de datos, entre otros.
Evaluación del fenómeno de la isla de calor urbano en Cartago, Colombia: tendencias de factores ambientales en los últimos 20 años
Authors: Garzón Julián , Molina Sánchez Iñigo , Jiménez Cleves Gonzalo
Published: October 2024

Las islas de calor urbano (ICU) son áreas urbanas que presentan temperaturas significativamente mayores que sus áreas rurales circundantes debido a actividades antropogénicas. Este estudio analiza el efecto de la ICU en Cartago-Valle del Cauca, Colombia, utilizando técnicas de teledetección y aprendizaje automático. Se emplearon imágenes Landsat de las últimas dos décadas para observar el comportamiento de la temperatura superficial terrestre (LST). Se aplicó un algoritmo monocanal para recuperar la distribución de LST, y se analizó la influencia de factores como el Índice de Agua de Diferencia Normalizada (NDWI) y el Índice de Construcción de Diferencia Normalizada (NDBI). Se emplearon técnicas como el Análisis de Componentes Principales (PCA), la Regresión Lineal Múltiple (MLR) y Máquinas de Vectores de Soporte (SVM) para identificar patrones, relaciones y generar mapas de análisis térmico urbano y recomendaciones de planificación. Los resultados indican un aumento anual promedio del 4,1% en la LST entre 2010 y 2020. La MLR mostró que factores como NDWI, NDBI, NDVI y PUC explican el 82% de la variabilidad en la tendencia térmica. Este estudio proporciona información relevante para desarrollar estrategias de mitigación y adaptación en entornos urbanos afectados por el calor.
Pengembangan Ensiklopedia Digital pada Pelajaran Ekosistem Berbasis Kurikulum Merdeka
Authors: Tristiyono Dicky , Carolina Hifni Septina
Published: October 2024

Ensiklopedia adalah media belajar yang memuat informasi, definisi, serta terdapat gambar dan video yang menarik. Hal ini sesuai dengan kurikulum merdeka yang memiliki karakteristik mengikuti gaya belajar siswa. Penelitian ini bertujuan untuk (1) Mengembangkan media pembelajaran ensiklopedia pada pelajaran ekosistem berbasis kurikulum merdeka. (2) Menganalisis kelayakan media pembelajaran ensiklopedia pada pelajaran ekosistem berbasis kurikulum merdeka. (3) Mengetahui respons guru dan siswa terhadap pengembangan ensiklopedia digital pada pelajaran ekosistem berbasis kurikulum merdeka.  Penelitian ini menggunakan metode research and development (R&D) dengan menggunakan model pengembangan ADDIE yang terdiri dari lima tahap yaitu Analysis, Design, Development, Implementation, dan Evaluation. Hasil penelitian adalah produk pembelajaran dalam bentuk Ensiklopedia digital yang telah melalui validasi oleh ahli materi dan ahli media serta uji coba dari respons guru dan respons siswa. Evaluasi persentase menunjukan bahwa ensiklopedia ini tergolong “sangat baik”, sehingga dapat digunakan sebagai media pembelajaran.
E-Modul Edu-Kehati Berbasis I-SETS: Pengembangan Bahan Ajar Beroientasi pada Literasi Keanekaragaman Hayati
Authors: Ristanto Rizhal Hendi , Heryanti Erna , Madaniyyah Salma
Published: October 2024

: E-modul merupakan salah satu bahan ajar yang banyak digunakan dalam proses pembelajaran guna mencapai tujuan pembelajaran. Pembelajaran I-SETS menjadikan siswa lebih mudah memahami materi pelajaran, karena siswa tidak hanya menguasai materi, namun juga peka terhadap permasalahan ataupun isu yang ada di masyarakat, serta dapat mengambil keputusan akan masalah-masalah yang sedang terjadi dan dapat mengaitkannya dengan nilai-nilai Islam. Penelitian ini bertujuan untuk mengembangkan modul elektronik keanekaragman hayati berbasis I-SETS berpotensi meningkatkan literasi keanekaragaman hayati siswa. Metode yang digunakan adalah research and development (R&D) dengan model pengembangan ADDIE yang terdiri dari lima tahapan, yaitu tahap analisis (Analysis), desain (Design), pengembangan (Development), implementasi (Implementation), dan evaluasi (Evaluation). Penelitian ini dibatasi pada uji kelompok kecil (small group evaluation) dengan subjek penelitian 30 peserta didik kelas X IPA MA. Data yang diperoleh berdasarkan instrumen uji kelayakan oleh validator ahli materi dan ahli media, uji coba oleh guru biologi, one to one evaluation, dan uji kelompok kecil. Hasil uji kelayakan oleh validator ahli materi mendapatkan rata-rata skor sebesar 4,20. Hasil uji kelayakan oleh validator ahli media mendapatkan rata-rata skor sebesar 4,20. Hasil uji coba guru biologi mendapatkan skor sebesar 4,10. Hasil one to one evaluation mendapatkan rata-rata skor sebesar 4,10 dan hasil uji coba kelompok kecil mendapatkan rata-rata skor sebesar 4,37 dengan kategori sangat layak. E-modul Edu-Kehati berbasis I-SETS layak untuk digunakan dalam pembelajaran materi keanekaragaman hayati dan berpotensi meningkatkan literasi keanekaragaman hayati siswa.
Hizkuntzarekin erlazionaturiko online informazioa europar hizkuntza gutxituetako hedabideetan
Authors: Zabaleta Urkiola Iñaki , Arriaga-Azkarate Tania , Martinez de Osaba Ruiz Gentzane
Published: October 2024

Artikulu honek, lehen aldiz era sistematikoki konparatzailean, hizkuntza gutxituei buruzko online informazioaren bolumen/estaldura eta garrantzia ikertzen ditu Europako bederatzi hizkuntza-komunitate gutxitutako prentsa, irrati eta telebista garrantzitsuenen webguneetan. Ikerketan, halaber, online albisteen framing edo enkoadraketa ere zedarritzen da, hainbat aldagai eta atributuren bitartez: izaera, eduki-tipologia, topos edo foku geografikoa, eta protagonisten profila. Gainera, emaitzak konparatu egiten dira hizkuntza nagusietako hedabide nagusien webguneen online albistegintzarekin. Europako bederatzi hizkuntza gutxituak euskara, galesa, galiziera, irlandera, bretoiera, frisiera, samiera, korsikera eta gaeliko eskoziarra dira.
Levrek (Dicentrarchus labrax) derisinden jelatin ekstraksiyonu: Fonksiyonel, tekstürel ve spektroskopik özelikler üzerine bir araştırma
Authors: Cansu Ümran
Published: October 2024

Balık derisi jelatini; gıda, kozmetik ve sağlık endüstrisinde önemli bir fonksiyonel ürün olarak değerlendirilmekte ve çeşitli balık türlerinin işleme atıklarından üretimi üzerine araştırmalar yapılmaktadır. Bu çalışmada; Levrek (Dicentrarchus labrax) derisinden jelatin elde edilmiş, elde edilen jelatinin kalitesi, fonksiyonel ve kimyasal özellikleri araştırılmış ve literatürdeki örnek çalışmalar ile karşılaştırılmıştır. Sonuçlar, levrek derisinden yüksek verimle (%35.15±0.05) jelatin üretilebileceğini ve yüksek jel gücü (281±8.0 g) ve viskozite (9.64±0.25-5.02±0.16 cP) değerlerine ulaşılabileceğini göstermiştir. Elde edilen jelatinin yüksek protein (88.92±0.16) oranına sahip olduğu ve tekstürel özellikleri itibariyle ticari ve diğer balık jelatini ürünlerine benzer özellikler gösterdiği tespit edilmiştir. Levrek derisi jelatininin UV absorpsiyonu ve FTIR spektrumu sonuçları, fonksiyonel grupların ve sekonder yapılarının ticari jelatinlerle benzer olduğunu göstermiştir. Toz jelatin örneğinin su tutma (STK), yağ bağlama (YBK) ve köpük oluşturma kapasitesi (KOK) sırasıyla, %184.80±8.70, 269.00±12.90 ve 68.30±5.80 olarak tespit edilmiştir. Sonuçlar, levrek derisi jelatininin biyolojik materyallerde doku iyileştirme gibi uygulamalarda ticari jelatine alternatif olarak kullanım potansiyelinin olduğunu göstermektedir.
Development of in silico methodologies to predict the toxicity of novel proteins in the context of food and feed risk assessment
Authors: Palazzolo L. , Laurenzi T. , Mariem O. Ben , Bassan A. , Guerrini U. , Eberini I.
Published: October 2024

Abstract
This report is the outcome of an EFSA procurement (OC/EFSA/GMO/2021/02 – LOT1) aiming at developing an in silico strategy to predict the toxicity of (novel) proteins. Up‐to‐date, commercially available tools predicting protein toxicity based on primary structures were evaluated for their accuracy and usability, using a curated dataset of annotated toxins and non‐toxins from UniProt. ToxinPred2 and Toxify emerged as the top performers, showing both high accuracy and suitability for integration into an automated pipeline. Additional bioinformatics methods were explored, which provide sequence similarity‐based information rather than direct predictions (BLAST, InterPro HMM profiles). By converting their outputs into features for machine learning models, a high prediction accuracy was achieved, though there is potential for improvement to reduce overfitting risks. An Artificial Intelligence (AI)‐based consensus pipeline, integrating results from ToxinPred2, Toxify, and our machine learning models was developed. This consensus model reached a 95% accuracy rate in distinguishing toxins from non‐toxins. Noteworthy, our BLAST‐based machine learning model ‐ although performance‐wise comparable to BLAST ‐ offers higher sensitivity and specificity across diverse queries than BLAST; it relies on database‐based evolutionary relationships, which may significantly limit its applicability to novel or mutated toxins. Structure‐based prediction methods are deemed impractical due to their resource intensity and reliance on accurate structural data; AI‐driven structure prediction methods ‐ like Rosetta and AlphaFold ‐ are promising, however they are still under development and may not be suitable for the regulatory context yet. Recommendations are provided, including enhancement of the proposed consensus pipeline to create an independent open‐source, user‐friendly tool for evaluating the safety of (novel) proteins in food and feed; regular updates of the proposed databases and models; incorporation of 3D structures and in general validation of AI and machine learning models for regulatory uses.
PARENTAL PERSPECTIVES ON FINANCING HIGHER EDUCATION: KEY INFLUENCING FACTORS
Authors: Raghu Ananthula , Kumari Dauli , K. Srivani
Published: October 2024

This research paper investigates the factors influencing parental decisions regarding the financing of children's higher education. It employs a descriptive survey method to examine parents' attitudes using a sample of 198 parents in Delhi. By analyzing responses to a scale covering motivational, economic, social, and institutional factors, the research aims to inform educational policies and support initiatives to enhance access to higher education. Findings indicate that a significant majority of parents prioritize their child's interests and aspirations, viewing education as a critical pathway to future security and personal growth. Financial stability, both current and past, plays a pivotal role in these decisions, with parents adopting a pragmatic approach to budgeting and exploring various funding options, including informal income streams and student loans. The reputation of educational institutions and the choice of courses significantly impact parental choices, as parents aim to maximize the potential returns on their investments. The study identifies the need for enhanced financial literacy and greater access to financial aid information, emphasizing the importance of transparency from educational institutions regarding outcomes and placement rates. Recommendations include developing financial education programs, community support systems, and tailored financial assistance strategies to accommodate diverse socioeconomic backgrounds. By addressing these factors, the paper aims to contribute to a deeper understanding of parental decision-making in higher education financing and promote a more equitable educational landscape.
Pitiriasis rubra pilaris infantil: a propósito de un caso
Authors: Renteria Lozano Sindy , Daza Vergara Juana T. , Esquivel Chico Vladimir , Ramirez Herodes
Published: October 2024

La pitiriasis rubra pilaris, es una enfermedad eritematoescamosa crónica, infrecuente, de origen desconocido, que provoca alteración en la queratinización de la epidermis. Se caracteriza por la presencia de pápulas foliculares, placas de color salmón que se intercala con áreas de piel normal, y queratodermia palmo plantar. Se presenta el caso de un niño de 6 años de edad, proveniente de la Provincia de Ciego de Ávila, Cuba, atendido en el servicio de dermatología del Hospital Pediátrico Juan Manuel Márquez, en la Habana, Cuba.
Un nuevo espacio académico hispano-latinoamericano: “una nueva luz de conocimiento”
Authors: Macías E María Angélica , Velásquez G Natalia
Published: October 2024

Para nosotras en un honor dar la bienvenida a todos ustedes a la primera edición de nuestra revista dedicada exclusivamente a la dermatología pediátrica. En un mundo donde la atención médica se diversifica y especializa cada vez más, es fundamental tener un espacio dedicado a la piel de nuestros pequeños pacientes.
El arte a gusto
Authors: Atuesta Negret Juan Jaime
Published: October 2024

A finales del año pasado fui gentil y generosamente convocado por la doctora María Angélica Macías para dirigir la sección cultural de nuestra revista, invitación que acepté encantado.
Histiocitosis de células de Langerhans: una actualización basada en un caso real. Parte 2
Authors: Zavala-Mena Mario , Jimeno-Ortega Isabel , Aedo-Inostroza Gabriel
Published: October 2024

Las histiocitosis son trastornos raros caracterizados por la acumulación de células dendríticas o macrófagos en diversos órganos, con predilección por piel y hueso (1). Su comportamiento clínico varía desde formas leves hasta potencialmente mortales (2). La primera clasificación de histiocitosis de 1987 (3) constaba de 3 categorías: Células de Langerhans (HCL), no relacionadas con LC (HCNL) e histiocitosis malignas (HM). Estas neoplasias inflamatorias pueden presentarse en formas limitadas, difusas o con compromiso multiorgánico (4), manifestándose de múltiples maneras e imitando a otras enfermedades, por lo que representan un desafío diagnóstico para la clínica.
DETERMINATION OF THE QUALITY ATTRIBUTES OF LEVODOPA-BASED NAZAL DROPS FOR THE TREATMENT OF PARKINSON'S DISEASE
Authors: Pavlov A. , Brkich G. , Pyatigorskaya N. , Zyryanov O.
Published: October 2024

Relevance. Currently, nasal delivery of drugs is considered as a relevant alternative to oral administration and opens up new possibilities for the treatment of neurodegenerative diseases of the brain. During the pharmaceutical development of a new form of nasal delivery of levodopa, the target quality profile of the drug was determined. The aim of this study was to develop a target quality profile for nasal drops based on api L-DOPA for further study of the stability and standardization of the drug. Material and methods. Experimental series of nasal drops containing levodopa (3,4-dihydroxy-l-phenylalanine - l-dopa), which is an oily suspension of polymer particles with micronized levodopa, which were evaluated by quality indicators in accordance with the requirements of the state pharmaco-poeia of the Russian Federation and the pharmacopoeia EAEU: authenticity and quantification (for an active pharmaceutical substance), as well as par-ticle size, sedimentation stability, pH value characterizing the dosage form "Suspensions", testing for acid number, peroxide value and a universal indi-cator for assessing the quality of all non-sterile dosage forms – microbiological purity . The HPLC method was used to determine the authenticity and quantitative content of L-DOPA in nasal drops. Results. As a result of studies of experimental series of nasal drops based on the active pharmaceutical ingredient L-DOPA, in accordance with the pharmacopoeial requirements for the active pharmaceutical ingredient, excipients and dosage form, a target quality profile of nasal drops based on levodopa was developed. The expediency of including the "Uniformity of dosing" test for an oil suspension has been established, since when adminis-tered intranasally, the drug is oriented towards a resorptive effect, which dictates the need to comply with the dosing conditions. Based on the results of the conducted studies of experimental series of levodopa-based nasal drops, a draft specification was developed containing the substantiated con-tent of quality targets and analysis methods. Conclusions. The developed quality targets for nasal drops will be used to study the stability, standardization and subsequent quality control of the drug.