bluuebunny/crossref_metadata_2025 huggingface dataset:
Body Composition and Spasticity in Children with Unilateral Cerebral Palsy—A Case–Control Study
Authors: Szkoda Lawia , Szopa Andrzej , Siwiec Andrzej , Kwiecień-Czerwieniec Ilona , Domagalska-Szopa Małgorzata
Published: December 2022

The aim of this study was to identify the correlations between segmental body composition and the spasticity level of the affected lower limb in children with unilateral cerebral palsy (spastic hemiplegia). Additionally, an attempt was made to identify the differences in composition between the affected and unaffected lower limbs using segmental body composition analysis. This case–control study included 31 children with spastic hemiplegia aged 8 to 16 years with differing severities of spasticity in the lower limbs. The reference group consisted of a control group which included 31 peers with corresponding age and sex to the tested group. Negative correlations obtained in the statistical analysis showed that higher spasticity level in the iliopsoas muscle is associated with lower limb fat-free mass and lower limb muscle mass. Our results showed that children with spastic hemiplegia have worse parameters of body composition in the affected limb than in the unaffected one. To confirm the importance of these results, further studies are needed in a larger population which includes non-ambulatory children.
Statistical Theory of Optimal Functionally Deterministic Signals Processing in Multichannel Aerospace Imaging Radar Systems
Authors: Volosyuk Valeriy , Zhyla Semen
Published: December 2022

The theory of the optimal formation of coherent and incoherent images is developed using the foundations of the statistical theory of optimization of radio engineering information-measuring systems. The main operations necessary for synthesizing optimal methods of spatio-temporal processing of functionally deterministic signals in on-board radio imaging radars with antenna arrays are shown. Models of radio engineering signals and noise have been developed. The statistical and correlation characteristics of spatio-temporal signals and noises in the area of their observation by antenna systems have been investigated. The technique for estimating the limiting errors of the measured characteristics of the studying media is presented. Using the developed theory, a new method for high-resolution radar imaging of the surface from a wide swath was obtained. This method has a new optimal observation mode combining the advantages of several terrain observation modes and fully complies with modern trends in the creation of cognitive radars with the possibility of restructuring the antenna pattern in space and adaptive receiving of reflected signals. The principles of construction and algorithmic support of high-precision airborne radars with an extended observation area are formulated. The effectiveness of the obtained results is investigated by simulation, taking into account the phenomenological approach to the description of electromagnetic fields and coherent images.
Total Phenolic Content, Antioxidant Capacity and UV Radiation Protection Properties of Marigold (Calendula officinalis), Carrot (Daucus carota), Tomato (Solanum lycopersicum) and Hop (Humulus lupulus) Extracts
Authors: Kurzawa Marzanna , Wilczyńska Emilia , Brudzyńska Patrycja , Sionkowska Alina
Published: December 2022

Total phenolic content using Folin–Ciocalteu method, antioxidant capacity by CUPRAC method and sun protection properties were measured for four different extracts of selected plants: marigold petals, carrot roots, tomato fruits and hop cones. Three types of extracts: water, oil and water-glycolic (1:4) were studied. Assessment of sun protection properties for extracts obtained from selected plants was first done by mathematical indication method and subsequently done spectrophotometrically. In a method of mathematical indication of UV protection based on absorption spectra, four parameters were determined regarding sun protection properties at different concentrations of selected plant extracts. Absorbance generally increased with an increase of concentration of extracts, but an expected increase of particular parameters was not obtained in all samples. The water-glycolic extract from hop cones was characterized by the highest content of phenolic compounds (among all studied samples) and high antioxidant activity. It also showed high radiation protection. Data for four parameters like UVA/UVB parameter, UVA1/UV parameter, SUI parameter and critical wavelength was generated, and the three first parameters were the highest for water and water-glycolic extracts of marigold. Among all plants, hop cones were characterized by the highest SPF for all types of extracts. SPF values increased with the concentration of extracts, but an increase of the weight of dried plants used to prepared extracts did not influence sun protection factor.
Exposure of Egyptian Rousette Bats (Rousettus aegyptiacus) and a Little Free-Tailed Bat (Chaerephon pumilus) to Alphaviruses in Uganda
Authors: Kading Rebekah C. , Borland Erin M. , Mossel Eric C. , Nakayiki Teddy , Nalikka Betty , Ledermann Jeremy P. , Crabtree Mary B. , Panella Nicholas A. , Nyakarahuka Luke , Gilbert Amy T. , Kerbis-Peterhans Julian C. , Towner Jonathan S. , Amman Brian R. , Sealy Tara K. , Miller Barry R. , Lutwama Julius J. , Kityo Robert M. , Powers Ann M.
Published: December 2022

The reservoir for zoonotic o’nyong-nyong virus (ONNV) has remained unknown since this virus was first recognized in Uganda in 1959. Building on existing evidence for mosquito blood-feeding on various frugivorous bat species in Uganda, and seroprevalence for arboviruses among bats in Uganda, we sought to assess if serum samples collected from bats in Uganda demonstrated evidence of exposure to ONNV or the closely related zoonotic chikungunya virus (CHIKV). In total, 652 serum samples collected from six bat species were tested by plaque reduction neutralization test (PRNT) for neutralizing antibodies against ONNV and CHIKV. Forty out of 303 (13.2%) Egyptian rousettes from Maramagambo Forest and 1/13 (8%) little free-tailed bats from Banga Nakiwogo, Entebbe contained neutralizing antibodies against ONNV. In addition, 2/303 (0.7%) of these Egyptian rousettes contained neutralizing antibodies to CHIKV, and 8/303 (2.6%) contained neutralizing antibodies that were nonspecifically reactive to alphaviruses. These data support the interepidemic circulation of ONNV and CHIKV in Uganda, although Egyptian rousette bats are unlikely to serve as reservoirs for these viruses given the inconsistent occurrence of antibody-positive bats.
A New Insight into the Composition and Physical Characteristics of Corncob—Substantiating Its Potential for Tailored Biorefinery Objectives
Authors: Gandam Pradeep Kumar , Chinta Madhavi Latha , Gandham A. Priyadarshini , Pabbathi Ninian Prem Prashanth , Konakanchi Srilekha , Bhavanam Anjireddy , Atchuta Srinivasa R. , Baadhe Rama Raju , Bhatia Ravi Kant
Published: December 2022

Corncobs of four different corn varieties were physically segregated into two different anatomical portions, namely the corncob outer (CO) and corncob pith (CP). The biomass composition analysis of both the CO and CP was performed by four different methods. The CP showed a higher carbohydrate and lower lignin content (83.32% and 13.58%, respectively) compared with the CO (79.93% and 17.12%, respectively) in all of the methods. The syringyl/guaiacyl (S/G) ratio was observed to be higher in the CP (1.34) than in the CO (1.28). The comprehensive physical characterization of both samples substantiated the lower crystallinity and lower thermal stability that was observed in the CP compared to the CO. These properties make the CP more susceptible to glycanases, as evident from the enzymatic saccharification of CP carried out with a commercial cellulase and xylanase in this work. The yields obtained were 70.57% and 88.70% of the respective theoretical yields and were found to be equal to that of pure cellulose and xylan substrates. These results support the feasibility of the tailored valorization of corncob anatomical portions, such as enzymatic production of xylooligosaccharides from CP without pretreatment combined with the bioethanol production from pretreated CO to achieve an economical biorefinery output from corncob feedstock.
Untargeted Metabolomics Associated with Behavioral and Toxicological Studies Yield Insights into the Impact of 2,6-Dichloro-3-hydroxy-1,4-benzoquinone Disinfection By-Product on Zebrafish Larvae
Authors: Chousidis Ieremias , Chatzimitakos Theodoros , Stalikas Constantine , Leonardos Ioannis
Published: December 2022

The disinfection by-product 2,6-dichloro-3-hydroxy-1,4-benzoquinone (2,6-DCBQ-OH) is a halobenzoquinone that emerges after chlorination. Therefore, it will inevitably come into contact with aquatic organisms. The aim of this study was to investigate the effect of 2,6-DCBQ-OH on zebrafish embryos. The dose-dependent toxicity was recorded, and the LC50 value was found to be 186 μg/L. Toxicity was accompanied with morphological, developmental, and behavioral abnormalities, and metabolic alterations. The association of phenotypic alterations with metabolic alterations was investigated through metabolomic study. In the control group, 25 metabolic pathways were identified, and 10 of them remained unaffected upon exposure to the halobenzoquinone. The upregulation of the glutathione pathway suggested that 2,6-DCBQ-OH can cause oxidative stress. In addition, the upregulation of the β-alanine metabolism pathway may be associated with the observed reduced swimming activity observed. Likewise, the downregulation of pathways associated with glycerophospholipids and butyrate can result in endocrine disruption, ineffective regulation of weight and body composition, and glucose homeostasis. The fatty acid elongation and synthesis of essential amino acids are downregulated, which can be associated with insufficient organogenesis at early life stages. In conclusion, exposure of zebrafish to 2,6-DCBQ-OH results in dysregulation and metabolic collapse of the organism, which ultimately result in developmental, morphological, behavioral, and other abnormalities.
Using a Fully Fractional Generalised Maxwell Model for Describing the Time Dependent Sinusoidal Creep of a Dielectric Elastomer Actuator
Authors: Karner Timi , Belšak Rok , Gotlih Janez
Published: December 2022

Actuators made of dielectric elastomers are used in soft robotics for a variety of applications. However, due to their mechanical properties, they exhibit viscoelastic behaviour, especially in the initial phase of their performance, which can be observed in the first cycles of dynamic excitation. A fully fractional generalised Maxwell model was derived and used for the first time to capture the viscoelastic effect of dielectric elastomer actuators. The Laplace transform was used to derive the fully fractional generalised Maxwell model. The Laplace transform has proven to be very useful and practical in deriving fractional viscoelastic constitutive models. Using the global optimisation procedure called Pattern Search, the optimal parameters, as well as the number of branches of the fully fractional generalised Maxwell model, were derived from the experimental results. For the fully fractional generalised Maxwell model, the optimal number of branches was determined considering the derivation order of each element of the branch. The derived model can readily be implemented in the simulation of a dielectric elastomer actuator control, and can also easily be used for different viscoelastic materials.
Sleep Disturbance, Psychological Distress and Perceived Burden in Female Family Caregivers of Dependent Patients with Dementia: A Case-Control Study
Authors: Simón Miguel A. , Bueno Ana M. , Blanco Vanessa , Otero Patricia , Vázquez Fernando L.
Published: December 2022

This case-control study analyzed the sleep disturbance, psychological distress and perceived burden in female family caregivers of dependent people with dementia (n = 74) compared with female family caregivers of dependent people without dementia (n = 74) and with age-matched non-caregiver control females (n = 74). Participants completed the Pittsburgh Sleep Quality Index (PSQI), the 12-item General Health Questionnaire (GHQ-12), the Caregiver Burden Inventory (CBI) and an ad hoc questionnaire to collect sociodemographic data. There were significant differences between the groups in PSQI total (F = 24.93; p < 0.001), psychological distress (F = 26.71; p < 0.001) and in all sleep domains assessed: subjective sleep quality (F = 16.19; p < 0.001), sleep latency (F = 9.5; p< 0.001), sleep duration (F = 18.57; p < 0.001), habitual sleep efficiency (F = 19.77; p < 0.001), sleep disturbances (F = 9.22; p < 0.001), use of sleep medications (F = 4.24; p< 0.01) and daytime dysfunction (F = 5.57; p < 0.01). In all measures, the female family caregivers of dependent people with dementia showed the significantly higher mean scores. Regarding the two groups of female caregivers, statistically significant differences were found in daily hours of care (t = −2.45; p < 0.05) and perceived burden (t = −3.65; p < 0.001), as well as in the following dimensions of caregiver burden: time-dependence burden (t = −5.09; p < 0.001), developmental burden (t = −2.42; p < 0.05) and physical burden (t = −2.89; p < 0.01). These findings suggest that female family caregivers of dependent patients with dementia should be subject to psychopathological screening and preventive cognitive-behavioral interventions in clinical practice in primary health care.
The Burden of Next-of-Kin Carers of Dementia Sufferers in the Home Environment
Authors: Tokovska Miroslava , Šolcová Jana
Published: December 2022

The role and responsibilities of next-of-kin carers are significant, filling several years of their lives and causing them to experience a burden of care. This study was conducted to investigate the burden of next-of-kin carers for dementia sufferers in Slovakia. Data were compiled via the Relatives’ Stress Scale (RSS) screening instrument through a survey of 112 primary next-of-kin carers and analysed using the statistical tests of descriptive statistics, means, scores and significance differences (Wilcoxon test). This is one of the few scales which provides: (a) specific measures of caregiver stress, and (b) is standardised for a population of informal carers in the home environment. The profiles of Slovak next-of-kin carers were identified with statistically significant characteristics (gender, age of carers). The study identified a high level of caregiving stress (82.15%), and selected factors were found to be significant in all burden dimensions: emotional stress (p = 0.001), social stress (p = 0.003), and negative feelings (p = 0.002). The results emphasise the need for coordination of healthcare and social services, possibly by expanding the network of social support groups, operating a counselling hotline/chat, and introducing national educational programmes for the next-of-kin carers of dementia sufferers. The results are also a source of reference for the umbrella organisation ‘the Slovak Alzheimer’s Society’ to access when implementing changes at a national level.
Effect of the Juggling-Based Motor Learning Physical Activity on Well-Being in Elderly: A Pre–Post Study with a Special Training Protocol
Authors: Malik Jakub , Maciaszek Janusz
Published: December 2022

Background: The importance of physical activity for the elderly is undeniable. Specific forms of exercise that are able to engage practitioners, both cognitively and physically, may provide more positive consequences for health and quality of life. Juggling is one of these activities that has both of these characteristics. Methods: Twenty elderly people (70.55 ± 4.91) were included in a juggling-based motor learning protocol for twelve training units during one month of exercising. An evaluation of the proposed exercises (five-point Likert scale) and a subjective assessment of well-being (WHO-5) were conducted during the protocol. Results: All participants learned to perform a three-ball flash cascade. Exercises were rated as very attractive (4.85 ± 0.31) by the practitioners, and a statistically significant improvement in well-being in participants was shown (p < 0.01; d = 0.76). Additionally, in the participating group, the number of people at risk of depression decreased significantly after the intervention with juggling classes (p < 0.01; g = 0.5). Conclusions: The proposed protocol could be an interesting physical activity for the elderly. It can be assumed that this activity, especially when performed in a group form, can improve the well-being of participants in a short period of time.
Age-Based Differences in Sleep Quality, Pre-Sleep Arousal, and Psychosocial Factors during the Second Wave Lockdown of the COVID-19 Pandemic in Georgia—A Higher Vulnerability of Younger People
Authors: Tsaava Mariam , Oniani Nikoloz , Eliozishvili Marine , Sakhelashvili Irine , Tkemaladze Nino , Aladashvili Tamar , Basishvili Tamar , Darchia Nato
Published: December 2022

The COVID-19 pandemic has deeply disrupted sleep and mental health of people around the world. We aimed to investigate age-based differences in the prevalence of and relationship between sleep quality, pre-sleep arousal, and psychosocial factors during the second wave lockdown of the COVID-19 pandemic in Georgia. Data were collected through an online survey (n = 1117). Participants were categorized into four age groups: 18–29, 30–41, 42–53, and 54–70 years. The youngest participants reported the most prevalent disruption of sleep behavior. Overall, 58.3% of respondents were poor sleepers. The Pittsburgh Sleep Quality Index (PSQI) global score was highest in the youngest age group but the difference was not significant. There was a significant difference in the PSQI component scores for subjective sleep quality, sleep latency, and daytime dysfunction, all being worse in young respondents. We also observed a significantly higher prevalence rate of worse sleep quality in the youngest age group, relative to the pre-pandemic period. On the other hand, the oldest respondents showed significantly greater use of sleeping medications. Significantly higher levels of somatic and cognitive pre-sleep arousal, perceived stress, feeling depressed, anxious, and socially isolated were reported by the youngest age group. Study findings indicate a higher vulnerability of younger people to the impact of the COVID-19 pandemic. Assessment of pre-sleep arousal and implementation of specific, age-based interventions may prove beneficial to improve possible consequences of the pandemic on sleep and mental health.
Assessment of Somatosensory and Motor Processing Time in Retired Athletes with a History of Repeated Head Trauma
Authors: Pearce Alan J. , King Doug , Kidgell Dawson J. , Frazer Ashlyn K. , Tommerdahl Mark , Suter Catherine M.
Published: December 2022

Measurement of the adverse outcomes of repeated head trauma in athletes is often achieved using tests where the comparator is ‘accuracy’. While it is expected that ex-athletes would perform worse than controls, previous studies have shown inconsistent results. Here we have attempted to address these inconsistencies from a different perspective by quantifying not only accuracy, but also motor response times. Age-matched control subjects who have never experienced head trauma (n = 20; 41.8 ± 14.4 years) where compared to two cohorts of retired contact sport athletes with a history of head trauma/concussions; one with self-reported concerns (n = 36; 45.4 ± 12.6 years), and another with no ongoing concerns (n = 19; 43.1 ± 13.5 years). Participants performed cognitive (Cogstate) and somatosensory (Cortical Metrics) testing with accuracy and motor times recorded. Transcranial magnetic stimulation (TMS) investigated corticospinal conduction and excitability. Results showed that there was little difference between groups in accuracy scores. Conversely, motor times in all but one test revealed that ex-athletes with self-reported concerns were significantly slower compared to other groups (p ranges 0.031 to <0.001). TMS latency showed significantly increased time (p = 0.008) in the group with ongoing concerns. These findings suggest that incorporating motor times is more informative than considering accuracy scores alone.
A Multimodal Knowledge-Based Deep Learning Approach for MGMT Promoter Methylation Identification
Authors: Capuozzo Salvatore , Gravina Michela , Gatta Gianluca , Marrone Stefano , Sansone Carlo
Published: December 2022

Glioblastoma Multiforme (GBM) is considered one of the most aggressive malignant tumors, characterized by a tremendously low survival rate. Despite alkylating chemotherapy being typically adopted to fight this tumor, it is known that O(6)-methylguanine-DNA methyltransferase (MGMT) enzyme repair abilities can antagonize the cytotoxic effects of alkylating agents, strongly limiting tumor cell destruction. However, it has been observed that MGMT promoter regions may be subject to methylation, a biological process preventing MGMT enzymes from removing the alkyl agents. As a consequence, the presence of the methylation process in GBM patients can be considered a predictive biomarker of response to therapy and a prognosis factor. Unfortunately, identifying signs of methylation is a non-trivial matter, often requiring expensive, time-consuming, and invasive procedures. In this work, we propose to face MGMT promoter methylation identification analyzing Magnetic Resonance Imaging (MRI) data using a Deep Learning (DL) based approach. In particular, we propose a Convolutional Neural Network (CNN) operating on suspicious regions on the FLAIR series, pre-selected through an unsupervised Knowledge-Based filter leveraging both FLAIR and T1-weighted series. The experiments, run on two different publicly available datasets, show that the proposed approach can obtain results comparable to (and in some cases better than) the considered competitor approach while consisting of less than 0.29% of its parameters. Finally, we perform an eXplainable AI (XAI) analysis to take a little step further toward the clinical usability of a DL-based approach for MGMT promoter detection in brain MRI.
Benthic Microbial Communities and Environmental Parameters of Estuary and Hypoxic Zone in the Bohai Sea, China
Authors: Gao Fan , Zhao Huade , Zhao Pengfei , Zhang Cuiya , Xu Guangjing , Liu Guize , Guo Xianyong
Published: December 2022

The sediment microbial community plays a key role in the cycling of organic matter in marine ecosystems. The characteristics of the sediment microbial community are significantly related to changes in the environment. In this study, we analyzed the diversity and distribution of microbial communities in sediments from different geographical regions (the Liao River estuary, Yellow River estuary, hypoxic zone, and offshore zone) of the Bohai Sea using high-throughput sequencing. The results showed that the community richness and diversity (especially the unique diversity) of the Liao River estuary were larger than those of the Yellow River estuary, hypoxic zone, and offshore zone. The phylum Proteobacteria dominated in the Liao River estuary (46.26%), hypoxic zone (76.19%), and offshore zone (69.79%), while the dominant phylum in the Yellow River estuary was the Bacteroidetes phylum. The genus Gillisia was the dominant genus in both the Liao River estuary and Yellow River estuary. The offshore zone and hypoxic zone shared the same dominant Photobacterium genus. The results of Pearson correlation and redundancy analysis showed that environmental parameters such as nitrite, silicate, nitrate, phosphate, ammonia, dissolved oxygen, pH, and salinity interfered significantly with the structure and diversity of the microbial community. The results of this study will provide support for future research on the interaction mechanism of pollutants and microorganisms in the estuaries and a typical hypoxic zone of the Bohai Sea.
Mathematical Model of an Offshore Friction Pile in Multilayered Saturated Soils
Authors: Guan Deyong , Meng Kun
Published: December 2022

In this paper, an analytical methodology is proposed to study the vibration of an offshore friction pile embedded in multilayered saturated viscoelastic soils by combining Biot’s saturated wave propagation theory, Novak’s plane-strain model, and the fictitious saturated soil pile model. The corresponding semi-analytical solution for the dynamic response of the pile is developed considering the heterogeneity, porosity, and limited thickness of the soils. The approach and relevant solution presented are validated by comparisons with existing solutions. Furthermore, numerical instances are used to investigate the influences of the porosity and heterogeneity of the saturated soils around and beneath the pile on the vibration of the pile. The findings from this paper provide a theoretical reference for a comprehensive understanding of the wave propagation characteristics of a friction pile embedded in heterogeneous saturated soil with limited thickness.
Energy-Saving Depth Control of an Autonomous Underwater Vehicle Using an Event-Triggered Sliding Mode Controller
Authors: Qi Yu , Wu Xinyu , Zhang Guocheng , Sun Yushan
Published: December 2022

In order to improve the endurance of underwater vehicles and make it possible for the underwater vehicle to inspect long-distance water tunnels, a sliding mode control method based on event triggering is proposed for the depth control of underwater vehicles from the perspective of energy saving. Firstly, the kinematics and dynamics models of underwater vehicle dive surface are established. Secondly, an event-triggered sliding mode controller is designed. According to the Lyapunov function, the stability of the designed controller is proved by theoretical analysis, and Zeno phenomena will not appear in the closed-loop control system. Compared with other controllers, the simulation results show that this controller can effectively realize the depth control of AUV, has strong adaptability and robustness to unmodeled nonlinear dynamics and bounded disturbances, and has the effect of saving computing resources.
Evolutionary Trajectories of Coastal Sand Barriers along the West Portuguese Coast during the Holocene
Authors: Costas Susana
Published: December 2022

Coastal sand barriers are dynamic features with complex depositional sequences holding critical information regarding system response to disturbances at secular to millennial time scales. Here, the evolutionary trajectories of three barriers located along the Portuguese coast are reconstructed over the Middle to Late Holocene using geophysical subsurface images, modern morphology and dating of dune and beach deposits. The integration of new and available information from the documents of the selected site contrasts histories with modern barriers displaying ages ranging from hundreds to thousands of years and non-linear trajectories defined by shifts between morphological states. Younger barriers appear to represent the latest progradational state within a history of landward barrier migration, where progradational states alternated with transgressive states. Conversely, the oldest barrier shows a single phase of barrier growth, despite some minor hiatus in progradation. Barrier state shifts appear to have simultaneously occurred across systems, suggesting external drivers of regional scale linked to Holocene climate variability, namely, periods of storminess activity, while the different trajectories displayed by the three sites appear related to site-specific variables controlling exposure to waves and winds. Exposed sites showed a lower ability to absorb disturbances and a greater range of system responses, varying between transgressive and progradational states.
Efficiency and Wave Run-Up of Porous Breakwater with Sloping Deck
Authors: Han Mengmeng , Wang Chien Ming
Published: December 2022

In order to protect fragile shoreline and coastal assets during extreme storms, a combined floating breakwater-windbreak has been proposed to reduce both wind and wave energies in the sheltered area. The 1 km-long breakwater has a porous hull with internal tubes to allow free passage of water; thereby further dissipating wave energy. The deck of the structure is designed to have a slope of 25 degrees facing the upstream side, and arrays of cylindrical tubes are placed on the sloping deck to form a windbreak. A reduced-scale (1:50) model test was carried out in a wave flume to examine wave sheltering performance under significant wave heights Hs = 3.0 m to 7.5 m and peak wave periods Tp = 9.4 s to 14 s sea states. Both regular and random wave conditions with different wave heights were considered. It is found that transmission coefficients ranging from 0.4 to 0.6 can be achieved under tested wave conditions. Porous breakwater hull increases the wave dissipation coefficients and is effective in reducing the wave reflection at the upstream side. The wave run-up length is dependent on the Iribarren number if the reduction induced by vertical freeboard is considered. Based on experimental data, empirical formulae have been proposed to predict the wave run-up responses in regular waves, probability of non-zero wave run-up occurrence, modified Weibull distribution of the wave run-up peaks and extreme wave run-up in random waves.
An Underwater Inductive Power Transfer System with a Compact Receiver and Reduced Eddy Current Loss
Authors: Yan Zhengchao , Zhao Chenxu , Hu Qianyu , Wu Min , Qiao Lin , Zhang Kehan , Hu Yuli
Published: December 2022

Inductive power transfer (IPT) technology is widely used in autonomous underwater vehicles (AUVs) to achieve safety and flexibility. However, the eddy current loss (ECL) will be generated in the seawater due to the high-frequency alternating current in the transmitter and receiver. An underwater IPT system with a series-none (SN) compensation topology is proposed in this paper to achieve a compact receiver for AUVs and reduce the ECL. The analytical model of the IPT system is built to analyze its transfer performance. The phase difference between the transmitter and receiver current of the SN compensation topology is larger than 90° compared to that of the conventional series-series (SS) topology, which can significantly decrease the magnitude of the electric field caused by coil currents; thus, the eddy current loss is reduced. Moreover, the optimal load resistance of the seawater IPT system is lower than that in the air, and the SN compensation topology has a more compact receiver with no compensation capacitor in the receiving side, which can save the internal space in the AUVs. An experimental prototype based on the SN topology is built, and the experimental results have verified the analysis.
Dynamic Response of a SPAR-Type Floating Wind Turbine Foundation with Taut Mooring System
Authors: Xiang Gong , Xiang Xianbo , Yu Xiaochuan
Published: December 2022

Compared with the traditional catenary or semi-taut mooring lines, the taut mooring system is more advantageous in many aspects, such as reduction of mooring line loads, erosion and fatigue damage during the powering productions of the floating wind turbines. This paper presents a taut mooring system made of synthetic fiber mooring lines, which can experience large elongations for a spar-type floating wind turbine. A finite element method (FEM)-based tensile mooring line model is proposed to study the mooring statics and dynamics of the floating wind turbine. A time domain modelling method coupled with the developed mooring line model is adopted to study the dynamics of a spar-type floating wind turbine foundation moored by the taut mooring system under regular waves. A systematic dynamic response and structural analysis are conducted based on variations in the mooring length and pretension. Additionally, comparative performance analyses are investigated for two mooring configurations with different numbers of mooring lines: two-point and three-point taut mooring system. It is found that factors, such as mooring length, pretension and the number of mooring lines, have significant impact on the in-plane and out-of-plane motion responses of the foundation.
Financial Fraud, Independent Female Directors and CEO Power
Authors: Yami Nafisah , Poletti-Hughes Jannine
Published: December 2022

This paper investigates the effect of female directors on financial fraud, focusing on the role of independent female directors and their demographics, such as experience, financial expertise, and audit committee membership. We find that independent female directors have a negative and significant influence on financial fraud, which is enhanced by their experience and financial expertise. The positive effect is also significant for those female directors that are members of the audit committee and have financial expertise. Independent female directors offset the increased likelihood of fraud in the presence of powerful CEOs, suggesting that the impact of their contribution is more valuable when there is managerial entrenchment.
Editorial: A Systemic Recovery
Authors: Grasselli Matheus R. , Kirman Alan , Hynes William
Published: December 2022

This Special Issue is about how we learn and apply the lessons of the COVID-19 pandemic [...]
Integrated Scheduling of Automated Yard Cranes and Automated Guided Vehicles with Limited Buffer Capacity of Dual-Trolley Quay Cranes in Automated Container Terminals
Authors: Naeem Doaa , Eltawil Amr , Iijima Junichi , Gheith Mohamed
Published: December 2022

Background: The key performance index for the container terminals is the vessel berthing time which is highly affected by the scheduling of the different handling equipment. Proper integrated scheduling of the handling equipment is crucial, especially in automated container terminals, where all the handling equipment is automated and must be coordinated to avoid interference. One of the most challenging problems both scholars and terminal operators face is introducing a proper scheduling plan for different equipment, considering the buffer capacity of dual-trolley quay cranes (QCs) and the limited storage locations of import containers. Methods: A mathematical model is proposed to integrate the scheduling of automated yard cranes and automated guided vehicles (AGVs), considering the limited buffer capacity beneath dual-trolley QCs and the storage allocation of import containers. Results: different instances were solved to evaluate the proposed model’s performance and investigate the impact of using dual-trolley QCs instead of single-trolley QCs, and the impact of using different buffer capacities. Conclusions: The results show that the model provides detailed scheduling and assigning plans for the YCs and AGVs besides allocating import containers. Additionally, the dual-trolley QCs can significantly decrease the completion time and increase AGVs’ utilization compared to the single-trolley QCs.
Random Motions at Finite Velocity on Non-Euclidean Spaces
Authors: Cybo Ottone Francesco , Orsingher Enzo
Published: December 2022

In this paper, random motions at finite velocity on the Poincaré half-plane and on the unit-radius sphere are studied. The moving particle at each Poisson event chooses a uniformly distributed direction independent of the previous evolution. This implies that the current distance d(P0,Pt) from the starting point P0 is obtained by applying the hyperbolic Carnot formula in the Poincaré half-plane and the spherical Carnot formula in the analysis of the motion on the sphere. We obtain explicit results of the conditional and unconditional mean distance in both cases. Some results for higher-order moments are also presented for a small number of changes of direction.
Molecular Cloning and Characterization of a New Family VI Esterase from an Activated Sludge Metagenome
Authors: Liaw Ren-Bao , Chen Jo-Ching , Cheng Mei-Ping
Published: December 2022

A new esterase gene, est6, was discovered in an activated sludge metagenomic library. The 729-bp gene encodes a 242-amino acid protein (designated Est6) with a molecular mass of 26.1 kDa. Est6 shared only a moderate identity to a putative hydrolase with the highest BLASTP analysis score. Most of the closely related proteins are uncharacterized and are predicted from genome sequencing data of microorganisms or metagenomic DNA sequences. The phylogenetic analysis of Est6 showed that the protein was assigned to family VI esterases/lipases. The catalytic triad of Est6 was predicted to be Ser135, Asp188, and His219, with Ser135 in a typically conserved pentapeptide (GFSQG) of family VI members, which was further confirmed by site-directed mutagenesis. The est6 gene was overexpressed successfully in its soluble form in Escherichia coli and then purified to its tag-free form and homogeneity by affinity chromatography. The purified Est6 in pH 8.0 buffer was active as a monomer. The optimal conditions for Est6 activity were at a temperature of 45 °C and pH of 8.0 when using p-nitrophenyl acetate as a substrate. The enzyme was stable over wide temperature and pH ranges, and it exhibited activity in the presence of organic solvents, metal cations, or detergents. Furthermore, the enzyme showed significant regioselectivity in the spectrophotometric analysis. In conclusion, Est6 might have the potential for applications in biotechnological processes.
Isolated Epiglottic Manifestations of HIV Infection: Two Cases Reports
Authors: Lee Yi-Chieh , Li Hsueh-Yu , Lin Wan-Ni
Published: December 2022

Diagnosis of the Human Immunodeficiency Virus (HIV) remains challenging due to non-specific clinical presentations and mostly flu-like symptoms, e.g., fever, headache, sore throat, and general weakness. Oral lesions, such as oral candidiasis and Kaposi sarcoma, are also frequently associated with HIV infection, whereas laryngeal manifestations are rare. We report two cases of newly diagnosed HIV patients with clinical presentations of sore throat, and endoscopy revealed an epiglottic ulcerative tumor-like lesion. A laryngomicrosurgical biopsy of the lesions was performed for persistent symptoms and suspicion of malignancy. The result revealed acute and chronic inflammation without a conclusive pathology diagnosis. Further laboratory analysis was arranged in consideration of autoimmune diseases, Epstein–Barr virus (EBV), and HIV infection due to their persistent and atypical symptoms. The results were positive for HIV infection. These patients were treated successfully with antiviral treatment and the laryngeal symptoms improved within weeks. In patients with idiopathic and persistent epiglottitis or an epiglottic ulcer after medical treatment, HIV infection needs to be considered as a potential etiology in order to institute proper treatment.
Glomerales Dominate Arbuscular Mycorrhizal Fungal Communities Associated with Spontaneous Plants in Phosphate-Rich Soils of Former Rock Phosphate Mining Sites
Authors: Ducousso-Détrez Amandine , Raveau Robin , Fontaine Joël , Hijri Mohamed , Lounès-Hadj Sahraoui Anissa
Published: December 2022

Arbuscular mycorrhizal fungi (AMF) are key drivers of soil functioning. They interact with multiple soil parameters, notably, phosphorus (P). In this work, AMF communities of native plants grown spontaneously on former mining sites either enriched (P sites) or not enriched with P (nP sites) by mining cuttings of rock phosphate (RP) were studied. No significant differences were observed in the root mycorrhizal rates of the plants when comparing P and nP sites. The assessment of AMF diversity and community structure using Illumina MiSeq metabarcoding and targeting 18S rDNA in roots and rhizospheric soils showed a total of 318 Amplicon Sequence Variants (ASVs) of Glomeromycota phylum. No significant difference in the diversity was found between P and nP sites. Glomeraceae species were largely dominant, formed a fungal core of 26 ASVs, and were persistent and abundant in all sites. In the P soils, eight ASVs were identified by indicator species analysis. A trend towards an increase in Diversisporaceae and Claroideoglomeraceae and a reduction in Paraglomeraceae and Glomeraceae were noticed. These results provide new insights into AMF ecology in former RP mining sites; they document that P concentration is a driver of AMF community structures in soils enriched in RP long term but also suggest an influence of land disturbance, ecosystem self-restoration, and AMF life history strategies as drivers of AMF community profiles.
Prophylaxis and Remediation for Future Pandemic Pathogens—(Lessons from a Post-COVID World)
Authors: Obrenovich Mark E. , Tayahi Moncef B. , Heidt Caryn L. , Emancipator Steven N.
Published: December 2022

Since influenza and coronaviruses are currently deadly and emerging threats worldwide, better treatment, remediation and prevention options are needed. In that regard, a basic understanding of severe acute respiratory syndrome (SARS)-CoV-2/COVID-19 (Betacoronaviridae) and other viral pathogen mechanisms of transmission are expected. Unfortunately, unprecedented, and growing distrust of vaccines and even masks or personal protective equipment (PPE) in the United States and elsewhere presents itself as an added challenge. We postulate that development of improved and highly effective prophylactic measures, together with new life-saving therapies that do inhibit or otherwise treat infection of SARS-CoV-2, influenza and other viral pathogens, could be an adjunct measure to globally protect vulnerable individuals from pandemic threats. In this review, we share what we learned from the past COVID experience to offer a multifactorial and improved approach to current and future pandemic infections or threats using low-cost means.
N Absorption, Transport, and Recycling in Nodulated Soybean Plants by Split-Root Experiment Using 15N-Labeled Nitrate
Authors: Doi Maria , Higuchi Kyoko , Saito Akihiro , Sato Takashi , Ohyama Takuji
Published: December 2022

Nitrate concentration is variable in soils, so the absorbed N from roots in a high-nitrate site is recycled from shoots to the root parts in N-poor niche. In this report, the absorption, transport, and recycling of N derived from 15N-labeled nitrate were investigated with split-root systems of nodulated soybean. The NO3− accumulated in the root in 5 mM NO3− solution; however, it was not detected in the roots and nodules in an N-free pot, indicating that NO3− itself is not recycled from leaves to underground parts. The total amount of 15NO3− absorption from 2 to 4 days of the plant with the N-free opposite half-root accelerated by 40% compared with both half-roots that received NO3−. This result might be due to the compensation for the N demand under one half-root could absorb NO3−. About 2–3% of the absorbed 15N was recycled to the opposite half-root, irrespective of N-free or NO3− solution, suggesting that N recycling from leaves to the roots was not affected by the presence or absence of NO3−. Concentrations of asparagine increased in the half-roots supplied with NO3− but not in N-free half-roots, suggesting that asparagine may not be a systemic signal for N status.
Topological and Optical Properties of Passeriformes’ Feathers: Biological UV Reflector Antenna
Authors: Singh P. , Jalil M. A. , Yupapin P. , Ali J. , Palomino M. A. , Toledo-Solano M. , Misaghian K. , Faubert J. , Ray K. , Bandyopadhyay A. , Lugo J. E.
Published: December 2022

This manuscript explores the topological and optical properties of a Passeriformes bird feather. Inside the feather, the layers of keratin and melanin are responsible for light reflection, transmission, and absorption; notably, the miniature composition of melanosome barbules plays a crucial role in its reflective properties. We adopted a multilayer interference model to investigate light propagation throughout the Passeriformes plume. As a result, we obtained all necessary simulated results, such as resonance band, efficiency, and electromagnetic radiation patterns of the Passeriformes plume, and they were verified with the experimental results reported in the literature study regarding light reflectivity through its internal geometry. Interestingly, we discovered that the interior structure of the Passeriformes plume functions similarly to a UV reflector antenna.
Study on the Relationship between Textile Microplastics Shedding and Fabric Structure
Authors: Cui Hong , Xu Changquan
Published: December 2022

Microplastics refer to plastic fibers, particles or films less than 5 mm in diameter. Textile microplastics are an important form of microplastics, which can harm the ecological environment and human health. This paper studies the relationship between textile microplastic shedding and fabric structure to reduce microplastics pollution and reduce its impact on humans and the natural environment. Firstly, household washing is simulated by considering the main fabric type, the number of steel balls used in the washing, washing temperature, washing time and other influencing factors. An orthogonal test of the mixing level of the four factors is designed by selecting the fabric type, the number of steel balls used in washing, washing temperature and washing time, and the influencing factors is analyzed, and the best washing scheme is obtained. Then, under optimal washing conditions, the three factors and three levels of orthogonal test are designed to analyze the influence of fabric structure and external factors on the shedding of microplastics by changing the amounts of friction and insolation time. The results show that the microplastics released by knitted fabrics are significantly more under the same washing conditions than that of woven fabrics. Satin fabrics released the most microplastics and plain fabrics the least. In addition, among the external factors, the amount of friction significantly affects the production of microplastics.
Metabolite Profiling of Tartary Buckwheat Extracts in Rats Following Co-Administration of Ethanol Using UFLC-Q-Orbitrap High-Resolution Mass Spectrometry
Authors: Xiang Liping , Xu Jian , Liu Wanyu , Wu Yue , Jiang Xin , Hu Yixin , Zhang Yao , Yang Qiang , Wang Zhe , Yang Yuejun , Wu Sanlan , Si Luqin , Huang Jiangeng , Zhang Yongjun
Published: December 2022

Tartary buckwheat, a gluten-free pseudocereal, has received considerable attention owing to its unique nutritional ingredients and beneficial health effects such as anti-tumor, anti-oxidation, anti-inflammation and hepatoprotective activities. Pharmacokinetic and metabolite profiling have been preliminarily assessed for Tartary buckwheat extracts. However, its metabolites have not yet been characterized in vivo after co-administration with ethanol when Tartary buckwheat extracts are used for the treatment of alcoholic liver disease. In this paper, a Q-Exactive orbitrap high-resolution mass spectrometer was employed to identify the metabolites of Tartary buckwheat extracts in rat biological samples. Compared with previous metabolite profiling results, a total of 26 novel metabolites were found in rat biological samples, including 11, 10, 2 and 5 novel metabolites in rat plasma, bile, urine and feces, respectively, after oral co-administration of 240 mg/kg Tartary buckwheat extracts with ethanol (42%, v/v). The major metabolic pathways of the constituents in Tartary buckwheat extracts involved hydroxylation, methylation, glucuronidation, acetylation and sulfation. Quercetin and its metabolites may be the pharmacological material basis of Tartary buckwheat for the protective effect against alcoholic liver injury. The research enriched in vivo metabolite profiling of Tartary buckwheat extracts, which provided experimental data for a comprehensive understanding and rational use of Tartary buckwheat against alcoholic liver disease.