bluuebunny/crossref_metadata_2025 huggingface dataset:
A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues
Authors: Van Liedekerke Paul , Neitsch Johannes , Johann Tim , Warmt Enrico , Gonzàlez-Valverde Ismael , Hoehme Stefan , Grosser Steffen , Kaes Josef , Drasdo Dirk
Published: November 2019

Mathematical models are increasingly designed to guide experiments in biology, biotechnology, as well as to assist in medical decision making. They are in particular important to understand emergent collective cell behavior. For this purpose, the models, despite still abstractions of reality, need to be quantitative in all aspects relevant for the question of interest. This paper considers as showcase example the regeneration of liver after drug-induced depletion of hepatocytes, in which the surviving and dividing hepatocytes must squeeze in between the blood vessels of a network to refill the emerged lesions. Here, the cells’ response to mechanical stress might significantly impact the regeneration process. We present a 3D high-resolution cell-based model integrating information from measurements in order to obtain a refined and quantitative understanding of the impact of cell-biomechanical effects on the closure of drug-induced lesions in liver. Our model represents each cell individually and is constructed by a discrete, physically scalable network of viscoelastic elements, capable of mimicking realistic cell deformation and supplying information at subcellular scales. The cells have the capability to migrate, grow, and divide, and the nature and parameters of their mechanical elements can be inferred from comparisons with optical stretcher experiments. Due to triangulation of the cell surface, interactions of cells with arbitrarily shaped (triangulated) structures such as blood vessels can be captured naturally. Comparing our simulations with those of so-called center-based models, in which cells have a largely rigid shape and forces are exerted between cell centers, we find that the migration forces a cell needs to exert on its environment to close a tissue lesion, is much smaller than predicted by center-based models. To stress generality of the approach, the liver simulations were complemented by monolayer and multicellular spheroid growth simulations. In summary, our model can give quantitative insight in many tissue organization processes, permits hypothesis testing in silico, and guide experiments in situations in which cell mechanics is considered important.
Consistent Provisions Mitigate Exposure to Sexual Risk and HIV Among Young Adolescents in South Africa
Authors: Toska Elona , Campeau Laurence , Cluver Lucie , Orkin F. Mark , Berezin McKenzie N. , Sherr Lorraine , Laurenzi Christina A. , Bachman Gretchen
Published: November 2019

Exposure to sexual risk in early adolescence strongly predicts HIV infection, yet evidence for prevention in young adolescents is limited. We pooled data from two longitudinal South African surveys, with adolescents unexposed to sexual risk at baseline (n = 3662). Multivariable logistic regression tested associations between intermittent/consistent access to eight provisions and reduced sexual risk exposure. Participants were on average 12.8 years, 56% female at baseline. Between baseline and follow-up, 8.6% reported sexual risk exposure. Consistent access to caregiver supervision (OR 0.53 95%CI 0.35–0.80 p = 0.002), abuse-free homes (OR 0.55 95%CI 0.37–0.81 p = 0.002), school feeding (OR 0.55 95%CI 0.35–0.88 p = 0.012), and HIV prevention knowledge (OR 0.43, 95%CI 0.21–0.88 p = 0.021) was strongly associated with preventing early sexual risk exposure. While individual factors reduced the odds of sexual risk exposure, a combination of all four resulted in a greater reduction, from 12.9% (95%CI 7.2–18.7) to 1.0% (95%CI 0.2–1.8). Consistent access to provisions in early adolescence may prevent sexual risk exposure among younger adolescents.
A nonlocal strain gradient shell model incorporating surface effects for vibration analysis of functionally graded cylindrical nanoshells
Authors: Lu Lu , Zhu Li , Guo Xingming , Zhao Jianzhong , Liu Guanzhong
Published: November 2019

In this paper, a novel size-dependent functionally graded (FG) cylindrical shell model is developed based on the nonlocal strain gradient theory in conjunction with the Gurtin-Murdoch surface elasticity theory. The new model containing a nonlocal parameter, a material length scale parameter, and several surface elastic constants can capture three typical types of size effects simultaneously, which are the nonlocal stress effect, the strain gradient effect, and the surface energy effects. With the help of Hamilton’s principle and first-order shear deformation theory, the non-classical governing equations and related boundary conditions are derived. By using the proposed model, the free vibration problem of FG cylindrical nanoshells with material properties varying continuously through the thickness according to a power-law distribution is analytically solved, and the closed-form solutions for natural frequencies under various boundary conditions are obtained. After verifying the reliability of the proposed model and analytical method by comparing the degenerated results with those available in the literature, the influences of nonlocal parameter, material length scale parameter, power-law index, radius-to-thickness ratio, length-to-radius ratio, and surface effects on the vibration characteristic of functionally graded cylindrical nanoshells are examined in detail.
The Discrete-Continuous, Global Optimisation of an Axial Flow Blood Pump
Authors: Tesch Krzysztof , Kaczorowska-Ditrich Katarzyna
Published: November 2019

This paper presents the results of the discrete-continuous optimisation of an axial flow blood pump. Differential evolution (DE) is used as a global optimisation method in order to localise the optimal solution in a relatively short time. The whole optimisation process is fully automated. This also applies to geometry modelling. Numerical simulations of the flow inside the pump are performed by means of the Reynolds-Average Navier-Stokes approach. All equations are discretised by means of the finite volume method, and the corresponding algebraic equation systems are solved by the open source software for CFD, namely OpenFOAM. Finally, the optimisation results are presented and discussed. The objective function to be maximised is simply pressure increase. The higher pressure increase the lower angular velocities required. This makes it possible to minimise the effect of haemolysis because it is mainly caused by high shear stresses which are related, among others, to angular velocities.
Verification of threshold for image intensity ratio analyses of late gadolinium enhancement magnetic resonance imaging of left atrial fibrosis in 1.5T scans
Authors: Bertelsen Litten , Alarcón Francisco , Andreasen Laura , Benito Eva , Olesen Morten Salling , Vejlstrup Niels , Mont Lluis , Svendsen Jesper Hastrup
Published: November 2019

The use of cardiovascular magnetic resonance imaging left atrial late gadolinium enhancement (LA LGE) is increasing for fibrosis evaluation though the use is still limited to specialized centres due to complex image acquisition and lack of consensus on image analyses. Analysis of LA LGE with image intensity ratio (IIR) (pixel intensity of atrial wall normalized by blood pool intensity) provides an objective method to obtain quantitative data on atrial fibrosis. A threshold between healthy myocardium and fibrosis of 1.2 has previously been established in 3T scans. The aim of the study was to reaffirm this threshold in 1.5T scans. LA LGE was performed using a 1.5T magnetic resonance scanner on: 11 lone-AF patients, 11 age-matched healthy volunteers (aged 27–44) and 11 elderly patients without known history of AF but varying degrees of comorbidities. Mean values of IIR for all healthy volunteers +2SD were set as upper limit of normality and was reproduced to 1.21 and the original IIR-threshold of 1.20 was maintained. The degree of fibrosis in lone-AF patients [median 9.0% (IQR 3.9–12.0)] was higher than in healthy volunteers [2.8% (1.3–8.3)] and even higher in elderly non-AF [20.1% (10.2–35.8), p = 0.001]. The previously established IIR-threshold of 1.2 was reaffirmed in 1.5T LA LGE scans. Patients with lone AF presented with increased degrees of atrial fibrosis compared to healthy volunteers in the same age-range. Elderly patients with no history of AF showed significantly higher degrees of fibrosis compared to both groups with younger individuals.
Increasing risks of apple tree frost damage under climate change
Authors: Pfleiderer Peter , Menke Inga , Schleussner Carl-Friedrich
Published: November 2019

Anthropogenic climate change is affecting agriculture and crop production. The responses of horticultural and agricultural systems to changing climatic conditions can be non-linear and at times counter-intuitive. Depending on the characteristics of the system, the actual impact can arise as a result of a combination of climate hazards or compound events. Here, we show that compound events can lead to increased risk of frost damage for apple fruit trees in Germany in a 2 °C warmer world of up to 10% relative to present day. Although the absolute number of frost days is declining, warmer winters also lead to earlier blossom of fruit trees, which in turn can lead to regionally dependent increased risks of the occurrence of frost days after apple blossom. In southern Germany, warmer winters may also lead to an increase in years in which apple yield is negatively affected by a lack of sufficient amount of cold days to trigger the seasonal response of the trees. Our results show how cropping system responses to seasonal climate can lead to unexpected effects of increased risk of frost damage as a result of warmer winters. An improved understanding of ecosystem responses to changes in climate signals is important to fully assess the impacts of climate change.
Analyzing territory for the sustainable development of solar photovoltaic power using GIS databases
Authors: Guaita-Pradas Inmaculada , Marques-Perez Inmaculada , Gallego Aurea , Segura Baldomero
Published: November 2019

Solar energy generated by grid-connected photovoltaic (GCPV) systems is considered an important alternative electric energy source because of its clean energy production system, easy installation, and low operating and maintenance costs. This has led to it becoming more popular compared with other resources. However, finding optimal sites for the construction of solar farms is a complex task with many factors to be taken into account (environmental, social, legal and political, technical-economic, etc.), which classic site selection models do not address efficiently. There are few studies on the criteria that should be used when identifying sites for solar energy installations (large grid-connected photovoltaic systems which have more than 100 kWp of installed capacity). It is therefore essential to change the way site selection processes are approached and to seek new methodologies for location analysis. A geographic information system (GIS) is a tool which can provide an effective solution to this problem. Here, we combine legal, political, and environmental criteria, which include solar radiation intensity, local physical terrain, environment, and climate, as well as location criteria such as the distance from roads and the nearest power substations. Additionally, we use GIS data (time series of solar radiation, digital elevation models (DEM), land cover, and temperature) as further input parameters. Each individual site is assessed using a unique and cohesive approach to select the most appropriate locations for solar farm development in the Valencian Community, a Spanish region in the east of Spain.
Running Rotterdam: on how locals’ participation in running events fosters their sense of place
Authors: Vink Ryanne , Varró Krisztina
Published: November 2019

Building on the insights of scholarship highlighting specific aspects of the forming of place meanings and experiences during running (events), this paper aims at applying a more holistic perspective on how meanings attached to and experiences of place by local runners are shaped through both individual and collective sense-making. Conceptually, the paper combines (post-)phenomenological and symbolic interactionist approaches. Empirically, the paper focuses on the Dutch city of Rotterdam and draws on extensive fieldwork conducted at the 2018 edition of the NN Marathon Rotterdam, and two smaller scale, non-commercially oriented running events organized by a local running club in 2017. Based on this qualitative research, the paper demonstrates that individual local runners’ understandings and embodied experience of the physical and social environment is always situated in, and interwoven with, broader social meanings and instances of shared embodiment. At the same time, the paper reflects on the methodological challenges faced by research on running (events) and calls for a more explicit acknowledgement of the multiple character of the running world(s) studied, and of the trade-offs between the different research techniques applied.
Accommodating Practices During Episodes of Disillusionment with Mobile IT
Authors: Zamani Efpraxia D. , Pouloudi Nancy , Giaglis George , Wareham Jonathan
Published: November 2019

This study investigates how tablet users react when technology falls short of their expectations. We deploy a data/frame model to study this process and investigate resistance-related reactions and the deployment of accommodating practices at the individual level. Analyzing user blogs that provide narratives on user interaction with tablets, we identify triggers of episodes of disillusionment and illustrate five sensemaking paths that users follow, eventually leading to one of three practices: 1) users choose to defer tasks until the situation changes, or they abandon the platform altogether; 2) they develop workarounds at different levels of proficiency; or 3) they proceed by reframing their expectations of the platform. By revealing user decision-making process during episodes of disillusionment, the findings contribute to information systems post-adoption research. At a practical level, the findings inform IT artifact and application design by offering insights on how users process discrepancies between their expectations and actual use experience.
BCG Moreau Vaccine Safety Profile and NK Cells—Double Protection Against Disseminated BCG Infection in Retrospective Study of BCG Vaccination in 52 Polish Children with Severe Combined Immunodeficiency
Authors: Bernatowska Ewa , Skomska-Pawliszak Małgorzta , Wolska-Kuśnierz Beata , Pac Małgorzata , Heropolitanska-Pliszka Edyta , Pietrucha Barbara , Bernat-Sitarz Katarzyna , Dąbrowska-Leonik Nel , Bohynikova Nadia , Piątosa Barbara , Lutyńska Anna , Augustynowicz Ewa , Augustynowicz-Kopeć Ewa , Korzeniewska-Koseła Maria , Krasińska Maria , Krzysztopa-Grzybowska Katarzyna , Wieteska-Klimczak Anna , Książyk Janusz , Jackowska Teresa , van den Burg Mirjam , van Dongen Jacques J. M. , Casanova Jean-Laurent , Picard Capucine , Mikołuć Bożena
Published: November 2019

Objectives

The aim of the study was to estimate the rate of adverse reactions to live BCG Moreau vaccine, manufactured by Biomed in Poland, in severe combined immunodeficiency (SCID) patients.

Material

The profiles of 52 SCID patients vaccinated at birth with BCG, hospitalized in Children’s Memorial Health Institute, Warsaw (CMHI), in the years 1980–2015 were compared with those of 349 BCG-vaccinated SCID patients from other countries analyzed by Beatriz E. Marciano et al. in a retrospective study (Marciano et al. J Allergy Clin Immunol. 2014;133(4):1134–1141).

Results

Significantly less disseminated BCG infections (10 out of 52 SCID, 19%) occurred in comparison with Marciano study—119 out of 349, 34% (p = 0.0028), with no death in patients treated with SCID anti-TB drug, except one in lethal condition. In our study, disseminated BCG infection was observed only in SCID with T-B+NK- phenotype and significantly lower NK cell counts (p = 0.0161). NK cells do not influence on the frequency of local BCG reaction. A significantly higher number of hematopoietic stem cells transplantations (HSCT) were performed in CMHI study (p = 0.0001). Anti-TB treatment with at least two medicines was provided.

Conclusion

The BCG Moreau vaccine produced in Poland, with well-documented genetic characteristics, seems to be safer than other BCG substrains used in other regions of the world. Importantly, NK cells seem to play a role in protecting SCID patients against disseminated BCG complications, which NK- SCID patients are more prone to. HSCT and TB therapy could be relevant due to the patients’ survival and the fact that they protect against BCG infection.
Stationary States in Infinite Volume with Non-zero Current
Authors: Carinci Gioia , Giardinà Cristian , Presutti Errico
Published: November 2019

We study the Ginzburg–Landau stochastic models in infinite domains with some special geometry and prove that without the help of external forces there are stationary measures with non-zero current in three or more dimensions.
The advantages of microfluidics to study actin biochemistry and biomechanics
Authors: Wioland Hugo , Suzuki Emiko , Cao Luyan , Romet-Lemonne Guillaume , Jegou Antoine
Published: November 2019

The regulated assembly of actin filaments is essential in nearly all cell types. Studying actin assembly dynamics can pose many technical challenges. A number of these challenges can be overcome by using microfluidics to observe and manipulate single actin filaments under an optical microscope. In particular, microfluidics can be tremendously useful for applying different mechanical stresses to actin filaments and determining how the physical context of the filaments affects their regulation by biochemical factors. In this review, we summarize the main features of microfluidics for the study of actin assembly dynamics, and we highlight some recent developments that have emerged from the combination of microfluidics and other techniques. We use two case studies to illustrate our points: the rapid assembly of actin filaments by formins and the disassembly of filaments by actin depolymerizing factor (ADF)/cofilin. Both of these protein families play important roles in cells. They regulate actin assembly through complex molecular mechanisms that are sensitive to the filaments’ mechanical context, with multiple activities that need to be quantified separately. Microfluidics-based experiments have been extremely useful for gaining insight into the regulatory actions of these two protein families.
Logical reduction of metarules
Authors: Cropper Andrew , Tourret Sophie
Published: November 2019

Many forms of inductive logic programming (ILP) usemetarules, second-order Horn clauses, to define the structure of learnable programs and thus the hypothesis space. Deciding which metarules to use for a given learning task is a major open problem and is a trade-off between efficiency and expressivity: the hypothesis space grows given more metarules, so we wish to use fewer metarules, but if we use too few metarules then we lose expressivity. In this paper, we study whether fragments of metarules can be logically reduced to minimal finite subsets. We consider two traditional forms of logical reduction: subsumption and entailment. We also consider a new reduction technique calledderivation reduction, which is based on SLD-resolution. We compute reduced sets of metarules for fragments relevant to ILP and theoretically show whether these reduced sets are reductions for more general infinite fragments. We experimentally compare learning with reduced sets of metarules on three domains: Michalski trains, string transformations, and game rules. In general, derivation reduced sets of metarules outperform subsumption and entailment reduced sets, both in terms of predictive accuracies and learning times.
The transformation of supreme values: Evidence from Poland on salvation through civic engagement
Authors: Fałkowski Jan , Kurek Przemysław
Published: November 2019

Peter Bernholz has described how ideologies and religions with supreme values have used violence to accomplish their goals. We describe the transformation of supreme values through civic engagement and pro-social behavior (dedication to common good, charity, participation in social life) that rejects as unacceptable all forms of violence. Our focus is on Catholicism after the Second Vatican Council, which emphasized the lay faithful’s role in the Church’s mission of salvation in the world and affirmed categorically that the duty of layperson is to serve other people and society. Using data on Poland, we find that the lay faithful try to fulfil those duties. Religious observance measured by participation in Holy Communion and church attendance correlates positively with civic engagement measured by the number of non-governmental organizations (NGOs).
Privacy protection in mobile crowd sensing: a survey
Authors: Wang Yongfeng , Yan Zheng , Feng Wei , Liu Shushu
Published: November 2019

The unprecedented proliferation of mobile smart devices has propelled a promising computing paradigm, Mobile Crowd Sensing (MCS), where people share surrounding insight or personal data with others. As a fast, easy, and cost-effective way to address large-scale societal problems, MCS is widely applied into many fields, e.g., environment monitoring, map construction, public safety, etc. Despite the popularity, the risk of sensitive information disclosure in MCS poses a serious threat to the participants and limits its further development in privacy-sensitive fields. Thus, the research on privacy protection in MCS becomes important and urgent. This paper targets the privacy issues of MCS and conducts a comprehensive literature research on it by providing a thorough survey. We first introduce a typical system structure of MCS, summarize its characteristics, propose essential requirements on privacy on the basis of a threat model. Then, we survey existing solutions on privacy protection and evaluate their performances by employing the proposed requirements. In essence, we classify the privacy protection schemes into four categories with regard to identity privacy, data privacy, attribute privacy, and task privacy. Besides, we review the achievements on privacy-preserving incentives in MCS from four viewpoints of incentive measures: credit incentive, auction incentive, currency incentive, and reputation incentive. Finally, we point out some open issues and propose future research directions based on the findings from our survey.
Low delay error resilience algorithm for H.265|HEVC video transmission
Authors: Alfaqheri Taha T. , Sadka Abdul Hamid
Published: November 2019

Transmission of high-resolution compressed video on unreliable transmission channels with time-varying characteristics such as wireless channels can adversely affect the decoded visual quality at the decoder side. This task becomes more challenging when the video codec computational complexity is an essential factor for low delay video transmission. High-efficiency video coding (H.265|HEVC) standard is the most recent video coding standard produced by ITU-T and ISO/IEC organisations. In this paper, a robust error resilience algorithm is proposed to reduce the impact of erroneous H.265|HEVC bitstream on the perceptual video quality at the decoder side. The proposed work takes into consideration the compatibility of the algorithm implementations with and without feedback channel update. The proposed work identifies and locates the frame’s most sensitive areas to errors and encodes them in intra mode. The intra-refresh map is generated at the encoder by utilising a grey projection method. The conducted experimental work includes testing the codec performance with the proposed work in error-free and error-prone conditions. The simulation results demonstrate that the proposed algorithm works effectively at high packet loss rates. These results come at the cost of a slight increase in the encoding bit rate overhead and computational processing time compared with the default HEVC HM16 reference software.
Insulin Signaling in Bone Marrow Adipocytes
Authors: Tencerova Michaela , Okla Meshail , Kassem Moustapha
Published: November 2019

Purpose of Review

The goal of this review is to discuss the role of insulin signaling in bone marrow adipocyte formation, metabolic function, and its contribution to cellular senescence in relation to metabolic bone diseases.

Recent Findings

Insulin signaling is an evolutionally conserved signaling pathway that plays a critical role in the regulation of metabolism and longevity. Bone is an insulin-responsive organ that plays a role in whole body energy metabolism. Metabolic disturbances associated with obesity and type 2 diabetes increase a risk of fragility fractures along with increased bone marrow adiposity. In obesity, there is impaired insulin signaling in peripheral tissues leading to insulin resistance. However, insulin signaling is maintained in bone marrow microenvironment leading to hypermetabolic state of bone marrow stromal (skeletal) stem cells associated with accelerated senescence and accumulation of bone marrow adipocytes in obesity.

This review summarizes current findings on insulin signaling in bone marrow adipocytes and bone marrow stromal (skeletal) stem cells and its importance for bone and fat metabolism. Moreover, it points out to the existence of differences between bone marrow and peripheral fat metabolism which may be relevant for developing therapeutic strategies for treatment of metabolic bone diseases.
The efficacy and safety of immune checkpoint inhibitors in non-small cell lung cancer patients of different age groups: a meta-analysis
Authors: Zheng S.-Y. , Cui H.-J. , Duan H. , Peng Y.-M. , Li Q. , Sun C.-Y. , Zhang J.-Y. , Shen W. , Zhang X. , Tan K. , Jiang X.
Published: November 2019

Background

Age is closely related to the efficacy of treatment for non-small cell lung cancer (NSCLC) patients. Latest clinical trials have proved the better overall survival (OS) for the use of immune checkpoint inhibitors verse chemotherapy in NSCLC patients. However, we had no clear idea of the efficacy of them in elderly patients. So we conducted a meta-analysis to compare the efficacy of immune checkpoint inhibitors for NSCLC patients of different age groups and summarized overall treatment-related adverse events.

Materials and methods

PubMed, EMBASE, Web of Science and the Cochrane Library were searched for all clinical trials in NSCLC until 30th of April 2019. Eligible studies included randomized controlled trials (RCTs) comparing immune checkpoint inhibitors with chemotherapy in NSCLC patients. The hazard ratio (HRs) and 95% confidence intervals (CIs) of OS, progression-free survival or adverse events (AEs) were used.

Results

A total of 4994 patients from 8 RCTs were included. Immune checkpoint inhibitors significantly prolonged the OS (HR, 0.73; 95% CI, 0.61–0.89) versus chemotherapy in NSCLC patients who were less than 65 years old. Also, they prolonged the OS (HR, 0.74; 95% CI, 0.59–0.93) in NSCLC patients who were more than 65 years old. However, there was no statistical significance of OS (HR, 0.87; 95% CI, 0.57–1.30) among NSCLC patients who were more than 75 years old. It also showed that the single use of immune checkpoint inhibitors had fewer all-grade AEs.

Conclusion

Regardless of the NSCLC patients who were less or more than 65 years, immune checkpoint inhibitors could achieve better OS than chemotherapy. But there was no significant difference when NSCLC patients who were more than 75 years old. Older patient should be offered immune therapies if it is possible and the mechanism in old age treatment should be further studied.
Evaluation of PiB visual interpretation with CSF Aβ and longitudinal SUVR in J-ADNI study
Authors:   Japanese Alzheimer’s Disease Neuroimaging Initiative, Okada Yusuke , Kato Takashi , Iwata Kaori , Kimura Yasuyuki , Nakamura Akinori , Hattori Hideyuki , Toyama Hiroshi , Ishii Kazunari , Ishii Kenji , Senda Michio , Ito Kengo , Iwatsubo Takeshi
Published: November 2019

Objective

The objectives of the present study were to investigate (1) whether trinary visual interpretation of amyloid positron emission tomography (PET) imaging (negative/equivocal/positive) reflects quantitative amyloid measurements and the time course of 11C-Pittsburgh compound B (PiB) amyloid accumulation, and (2) whether visually equivocal scans represent an early stage of the Alzheimer’s disease (AD) continuum in terms of an intermediate state of quantitative amyloid measurements and the changes in amyloid accumulation over time.

Methods

From the National Bioscience Database Center Human Database of the Japanese Alzheimer’s Disease Neuroimaging Initiative, we selected 133 individuals for this study including 33 with Alzheimer’s disease dementia (ADD), 52 with late mild cognitive impairment (LMCI), and 48 cognitively normal (CN) subjects who underwent clinical assessment, PiB PET, and structural magnetic resonance imaging (MRI) with 2 or 3-years of follow-up. Sixty-eight of the 133 individuals underwent cerebrospinal fluid amyloid-β1-42 (CSF-Ab42) analysis at baseline. The standard uptake value ratio (SUVR) of PiB PET was calculated with a method using MRI at each visit. The cross-sectional values, longitudinal changes in SUVR, and baseline CSF-Ab42 were compared among groups, which were categorized based on trinary visual reads of amyloid PET (negative/equivocal/positive).

Results

From the trinary visual interpretation of the PiB PET images, 55 subjects were negative, 8 were equivocal, and 70 were positive. Negative interpretation was most frequent in the CN group (70.8/10.4/18.8%: negative/equivocal/positive), and positive was most frequent in the LMCI group (34.6/1.9/63.5%) and in the ADD group (9.1/6.1/84.8%). The baseline SUVRs were 1.08 ± 0.06 in the negative group, 1.23 ± 0.15 in the equivocal group, and 1.86 ± 0.31 in the positive group (F = 174.9, p < 0.001). The baseline CSF-Ab42 level was 463 ± 112 pg/mL in the negative group, 383 ± 125 pg/mL in the equivocal group, and 264 ± 69 pg/mL in the positive group (F = 37, p < 0.001). Over the 3-year follow-up, annual changes in SUVR were − 0.00 ± 0.02 in the negative group, 0.02 ± 0.02 in the equivocal group, and 0.04 ± 0.07 in the positive group (F = 8.4, p < 0.001).

Conclusions

Trinary visual interpretation (negative/equivocal/positive) of amyloid PET imaging reflects quantitative amyloid measurements evaluated with PET and the CSF amyloid test as well as the amyloid accumulation over time evaluated with PET over 3 years. Subjects in the early stage of the AD continuum could be identified with an equivocal scan, because they showed intermediate quantitative amyloid PET, CSF measurements, and the amyloid accumulation over time.
Do rebel workers in the honeybee Apis mellifera avoid worker policing?
Authors: Rojek Wiktoria , Kuszewska Karolina , Ostap-Chęć Monika , Woyciechowski Michał
Published: November 2019

A recent study showed that worker larvae fed in a queenless colony develop into another female polyphenic form—rebel workers. The rebel workers are more queen-like than normal workers because they have higher reproductive potential revealed by more ovarioles in their ovaries. However, it was unclear whether eggs laid by rebel workers avoided worker policing. Worker-laid eggs are normally eaten by other workers in a queenright colony. The aim of this study was to compare the survival of three classes of eggs, namely, those laid by normal workers, rebel workers, and the queen. All eggs were tested in queenright colonies. We expected that rebel workers would avoid policing by laying more queen-like eggs. Contrary to our expectations, eggs laid by rebel workers were eaten by other workers, as were eggs laid by normal workers, and only a few worker-laid eggs (both normal and rebel) survived for more than 3 h. Therefore, in a queenright colony, eggs laid by rebel workers do not avoid policing.
Frame-based terminology applied to military science
Authors: Faber Pamela , León‑Araúz Pilar
Published: November 2019

This paper describes a Frame-Based Terminology approach to the military terminology of the Spanish Armed Forces. The alphabetically organized (PD0-000) glossary of military terms of the Spanish Armed Forces was transformed into MiliMarco [MiliFrame], a bilingual terminological knowledge base in which each concept appears within a hierarchy of conceptual categories and a semantic network. Framebased resources enhance access to domain knowledge in a contextualized way, since embedding concepts in a knowledge structure activates associative information in semantic memory and promotes context availability. The design and population of MiliMarco involved the analysis and transformation of the content in the glossary entries as well as the extraction of new information. For this purpose, specialized knowledge structures were elaborated from the defnitions in the glossary and from the lexicalization of semantic relations in the corpus. New concepts were added to fll the gaps in the glossary and additional data categories were included, such as images, collocations, and contexts. Previous work on military ontologies, usually in the form of controlled, structured vocabularies, is limited to a specifc domain (e.g., military intelligence). MiliMarco has the advantage of providing an expanded view of the military domain in the form of conceptual networks combined with linguistic contexts that go far beyond simple hierarchies. Although still an ongoing project, the resulting knowledge base is currently a concept-oriented resource where users can browse through the conceptual hierarchy and semantic networks based on their cognitive and communicative needs.
Risk Management and Analytics in Wildfire Response
Authors: Thompson Matthew P. , Wei Yu , Calkin David E. , O’Connor Christopher D. , Dunn Christopher J. , Anderson Nathaniel M. , Hogland John S.
Published: November 2019

Purpose of Review

The objectives of this paper are to briefly review basic risk management and analytics concepts, describe their nexus in relation to wildfire response, demonstrate real-world application of analytics to support response decisions and organizational learning, and outline an analytics strategy for the future.

Recent Findings

Analytics can improve decision-making and organizational performance across a variety of areas from sports to business to real-time emergency response. A lack of robust descriptive analytics on wildfire incident response effectiveness is a bottleneck for developing operationally relevant and empirically credible predictive and prescriptive analytics to inform and guide strategic response decisions. Capitalizing on technology such as automated resource tracking and machine learning algorithms can help bridge gaps between monitoring, learning, and data-driven decision-making.

By investing in better collection, documentation, archiving, and analysis of operational data on response effectiveness, fire management organizations can promote systematic learning and provide a better evidence base to support response decisions. We describe an analytics management framework that can provide structure to help deploy analytics within organizations, and provide real-world examples of advanced fire analytics applied in the USA. To fully capitalize on the potential of analytics, organizations may need to catalyze cultural shifts that cultivate stronger appreciation for data-driven decision processes, and develop informed skeptics that effectively balance both judgment and analysis in decision-making.
Examining Patterns in Teacher-Student Classroom Conversations during STEM Lessons
Authors: Wang Hui-Hui
Published: November 2019

Teacher-student conversations are central to student learning within the science classroom. Educational literature recommends teachers aim to build a common scientific language and, through dialog, develop shared meanings with students. This study examines teacher-student conversations in the specific situation of an integrated science and engineering curriculum, involving lessons on heat transfer. The findings identify critical nuances and discourse patterns in the conversations that may pose barriers to student engagement and learning. The study illustrates the need for teachers to plan dialogic, authentic interaction with students to build shared meanings about scientific concepts in order to enhance STEM learning.
Social Media's Impact on the Consumer Mindset: When to Use Which Sentiment Extraction Tool?
Authors: Kübler Raoul V. , Colicev Anatoli , Pauwels Koen H.
Published: November 2019

User-generated content provides many opportunities for managers and researchers, but insights are hindered by a lack of consensus on how to extract brand-relevant valence and volume. Marketing studies use different sentiment extraction tools (SETs) based on social media volume, top-down language dictionaries and bottom-up machine learning approaches. This paper compares the explanatory and forecasting power of these methods over several years for daily customer mindset metrics obtained from survey data. For 48 brands in diverse industries, vector autoregressive models show that volume metrics explain the most for brand awareness and purchase intent, while bottom-up SETs excel at explaining brand impression, satisfaction and recommendation. Systematic differences yield contingent advice: the most nuanced version of bottom-up SETs (SVM with Neutral) performs best for the search goods for all consumer mind-set metrics but Purchase Intent for which Volume metrics work best. For experienced goods, Volume outperforms SVM with neutral. As processing time and costs increase when moving from volume to top-down to bottom-up sentiment extraction tools, these conditional findings can help managers decide when more detailed analytics are worth the investment.
POWDERMET2019 in Phoenix – Overview
Authors: Capus Joseph
Published: November 2019

The MPIF took its annual conferences out West to Phoenix to celebrate the 75th anniversary of its founding. Meanwhile the North American PM industry faced a subdued business outlook after modest growth in 2018.
Design of large-displacement asymmetric piezoelectric microgripper based on flexible mechanisms
Authors: Chen Xiaodong , Hu Siya , Deng Zilong , Gao Jinhai , Gao Xingjun
Published: November 2019

The output displacement of the traditional symmetrical microgripper is large, but its micro-components or parts are easily damaged due to the uneven force exerted on the left and right jaws of the gripper. The output force of the traditional asymmetric microgripper is stable. However, its output displacement is small, typically half the output displacement of the symmetric microgripper. To solve these problems, in this study, we designed a large-displacement asymmetric microgripper. First, we calculated the relationship between the theoretical input and output variables based on their geometric relationship. Then, we analyzed the performance of the microgripper using finite element software. Lastly, we used a piezoelectric actuator as the input driver of the microgripper. The errors associated with the theoretical and simulated output displacements were 7.05% and 9.24%, respectively. At 150 V of driving voltage, the maximum output displacement was 224 µm, and the actual magnification was 11.2 times. Microparts can be gripped in parallel and stably, which confirms the validity of the design.
The Great Pagoda at Kew: Colour and Technical Innovation in Chinoiserie Architecture
Authors: Prosser Lee
Published: November 2019

The Great Pagoda in Kew Gardens is the most important surviving chinoiserie building in Europe. Restoration of the building in 2017–18 was attended by extensive documentary and forensic research, which revealed two markedly different eighteenth-century schemes of decoration undertaken by the architect William Chambers in 1761 and 1784. Both schemes were characterised by the use of innovative and experimental building materials and the application of a varied colour palette which can be shown to have close affinities with temporary, ephemeral buildings. With so few surviving contemporary examples for reference, colour and building materials appear as important characteristics of chinoiserie architecture. The discoveries at Kew demonstrate that these elements were fundamental to the style, which was never constrained by any fixed set of rules. Chambers drew on no single source for the building, but instead imaginatively adapted the Chinese style in a structure of great virtuosity.
Confirmation Based on Analogical Inference: Bayes Meets Jeffrey
Authors: Feldbacher-Escamilla Christian J. , Gebharter Alexander
Published: November 2019

Certain hypotheses cannot be directly confirmed for theoretical, practical, or moral reasons. For some of these hypotheses, however, there might be a workaround: confirmation based on analogical reasoning. In this paper we take up Dardashti, Hartmann, Thébault, and Winsberg’s (2019) idea of analyzing confirmation based on analogical inference Bayesian style. We identify three types of confirmation by analogy and show that Dardashti et al.’s approach can cover two of them. We then highlight possible problems with their model as a general approach to analogical inference and argue that these problems can be avoided by supplementing Bayesian update with Jeffrey conditionalization.
Power/Memory: New Elite, Old Intelligentsia, and Fixing of the Georgian Mind
Authors: Batiashvili Nutsa
Published: November 2019

This article examines an ideological and a narrative rift between two elitist formations and two forms of nationalism that a practice of memory-making embodies. In the subterranean polemic where Soviet generation intelligentsia and liberal intellectuals animate the past on Russian–Georgian relations in two distinct ways, past becomes a critical terrain where the struggle over Georgia’s geopolitical belonging and the resulting disputes on national identity take place. This analysis not only flashes out recent discursive rifts, linking them to the broader political processes, but traces the genealogies of the narrative practices that enable two idioms of nationalist discourse. It is both an analysis of post-socialist class formations and of the semantic fields within which their idioms are embedded.
GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey II: Galactic plane 345° <l< 67°, 180° <l< 240°
Authors: Hurley-Walker N. , Hancock P. J. , Franzen T. M. O. , Callingham J. R. , Offringa A. R. , Hindson L. , Wu C. , Bell M. E. , For B.-Q. , Gaensler B. M. , Johnston-Hollitt M. , Kapińska A. D. , Morgan J. , Murphy T. , McKinley B. , Procopio P. , Staveley-Smith L. , Wayth R. B. , Zheng Q.
Published: November 2019

This work makes available a further$2\,860~\text{deg}^2$of the GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey, covering half of the accessible galactic plane, across 20 frequency bands sampling 72–231 MHz, with resolution$4\,\text{arcmin}-2\,\text{arcmin}$. Unlike previous GLEAM data releases, we used multi-scaleCLEANto better deconvolve large-scale galactic structure. For the galactic longitude ranges$345^\circ < l < 67^\circ$,$180^\circ < l < 240^\circ$, we provide a compact source catalogue of 22 037 components selected from a 60-MHz bandwidth image centred at 200 MHz, with RMS noise$\approx10-20\,\text{mJy}\,\text{beam}^{-1}$and position accuracy better than 2 arcsec. The catalogue has a completeness of 50% at${\approx}120\,\text{mJy}$, and a reliability of 99.86%. It covers galactic latitudes$1^\circ\leq|b|\leq10^\circ$towards the galactic centre and$|b|\leq10^\circ$for other regions, and is available from Vizier; images covering$|b|\leq10^\circ$for all longitudes are made available on the GLEAM Virtual Observatory (VO).server and SkyView.
Reforming the Purposes of Sentencing to Affirm African Values in Namibia
Authors: Ndeunyema Ndjodi
Published: November 2019

This article considers the current sentencing purposes in Namibia. It discusses the legislator's failure to articulate these purposes, leaving this to the judiciary, and identifies the dangers that arise from this legislative lacuna. It establishes that current sentencing purposes are fundamentally premised upon a retributivist philosophy, transplanted into Namibia during the colonial period. The article thus advocates for sentencing reform, aimed at restoring a paradigm based on African values. It does so by analysing African indigenous justice systems, usingUbuntuas an Afrocentric value. The article establishes howUbuntuis contemporarily mirrored by restorative notions of justice that prioritize victims, offenders and the community, thereby asserting sentencing purposes that promote reconciliation, reparation and offender re-integration. In juxtaposing this with other sentencing purposes, the article critiques comparable jurisdictions that have recently incorporated restorative justice and proposes a set of draft sentencing purposes in the appendix.
Food addiction, eating addiction and eating disorders
Authors: Hauck Carolin , Cook Brian , Ellrott Thomas
Published: November 2019

The concept of food addiction is currently a highly debated subject within both the general public and the scientific communities. The term food addiction suggests that individuals may experience addictive-like responses to food, similar to those seen with classic substances of abuse. An increasing number of studies have established the prevalence and correlates of food addiction. Moreover, food addiction may be associated with obesity and disordered eating. Thus, intervening on food addiction may be helpful in the prevention and therapy of obesity and eating disorders. However, controversy exists about if this phenomenon is best defined through paradigms reflective of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) substance-related disorders (e.g. food addiction) or non-substance-related disorders (e.g. eating addiction) criteria. This review paper will give a brief summarisation of the current state of research on food addiction, a more precise definition of its classification, its differentiation from eating addiction and an overview on potential overlaps with eating disorders. Based on this review, there is evidence that food addiction may represent a distinct phenomenon from established eating disorders such as bulimia nervosa or binge-eating disorder. Future studies are needed to further examine and establish orthogonal diagnostic criteria specific to food addiction. Such criteria must differentiate the patterns of eating and symptoms that may be similar to those of eating disorders to further characterise food addiction and develop therapy options. To date, it is too premature to draw conclusions about the clinical significance of the concept of food addiction.
Explaining historical change in terms of LHT: A pluralistic causal framework is needed
Authors: Allard Aurélien , Marie Antoine
Published: November 2019

Baumard suggests that the advent, through phenotypic plasticity mechanisms, of future-oriented preferences and creative mindsets in eighteenth-century Great Britain explains the wave of innovations that drove the British Industrial Revolution. We argue that, although this approach is promising, Baumard's model would benefit from being supplemented by demographic, economic, and sociological explanations independent of Life History Theory (LHT).