bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison Efficacy between Percutaneous Nephrostomy and Double J Stent in Management of Obstructive Uropathy
Authors: Khan Saeed Ahmed , Kumar Naresh , Bux Khuda , Chachar Muneer Ahmed , Bangwarah Abdul Karim
Published: March 2024

Background: The prevalence of urolithiasis and associated acute kidney injury (AKI) has seen a notable increase in recent decades, particularly in developing countries such as Pakistan, which falls within the "stone forming belt" region. This rise has underscored the need for effective management strategies for obstructive uropathy, a potentially reversible condition if timely intervention is provided. However, the literature reveals a divergence in treatment approaches between different regions and among healthcare professionals, with no universally recommended treatment for relieving the obstructed system.
Objective: This study aimed to evaluate and compare the efficacy of percutaneous nephrostomy (PCN) versus Double J stent (DJS) in the management of obstructive uropathy secondary to urolithiasis in patients with elevated serum creatinine levels.
Methods: Conducted as a randomized controlled trial at the Jinnah Postgraduate Medical Center Karachi from January 2023 to December 2023, the study included patients aged 20 to 50 years with obstructive uropathy secondary to urolithiasis and serum creatinine above or equal to 2.0 mg/dL. Exclusion criteria encompassed obstructive uropathy due to bladder outlet obstruction, uncontrolled coagulopathy, and lack of consent. Participants were randomized into two groups for either PCN or DJS placement, with pre-operative and post-procedure serum creatinine and urea levels measured at multiple intervals. Data analysis was performed using SPSS version 25.
Results: The study enrolled 30 patients in the PCN group and 30 in the DJS group. Efficacy rates for PCN and DJS were 93.3% (28 out of 30) and 76.7% (23 out of 30), respectively. Stratified analysis revealed no statistically significant differences in efficacy based on age, gender, or duration of illness, although a trend favoring PCN was observed in patients over 40 years and those treated within 5-10 days of illness onset.
Conclusion: While both PCN and DJS are effective interventions for obstructive uropathy secondary to urolithiasis, PCN showed a non-significantly higher overall efficacy. These findings suggest a potential preference for PCN in certain patient subsets, though further research with larger sample sizes and multi-center trials is needed to substantiate these observations.
Investigation of Color Vision and Contrast Sensitivity Defects in Textile Industry Workers
Authors: Amin Nida , Shabbir Hina , Fatima Nimra , Riaz Attiqa , Siddiqui Sadia
Published: March 2024

Background: Industrial exposure to chemicals is a significant health concern, particularly within the textile industry where workers are in regular contact with potentially harmful substances. The retina, with its photoreceptor cells responsible for color vision and contrast sensitivity, is especially susceptible to damage from such exposure.
Objective: This study aims to assess the impact of chemical exposure on the color vision and contrast sensitivity of workers in the Five Star Textile Industry, drawing comparisons with previous research to better understand the occupational risks and requisite protective measures.
Methods: A cross-sectional, descriptive study was conducted on 100 workers with an age range of 20-50 years, examining 200 eyes. The research took place from January to June 2023, employing the Pelli-Robson chart and D-15 test for evaluating contrast sensitivity and color vision, respectively. Data were analyzed using the Pearson Chi-Square test and SPSS version 25.
Results: The study found a Pearson Chi-Square value of 31.4 for color vision in the right eye and 25.7 in the left, with a significance of 0.000 for both. Contrast sensitivity tests revealed a Pearson Chi-Square value of 44.2 for both eyes, with significance remaining at 0.000, indicating a strong correlation between chemical exposure and visual impairment.
Conclusion: The findings suggest a significant relationship between prolonged chemical exposure and visual function decline among textile workers, underlining the necessity for enhanced occupational health protocols and regular vision screening.
Integrated Pest Management Precision: Harnessing the Joint Influence of Entomopathogenic Fungi, Nematodes, and Chlorantraniliprole for Targeted Control of Fall Armyworm (Spodoptera Frugiperda)
Authors: Razzaq Mahwish , Arshad Fatima , Bashir Riffat , Iftikhar Sania
Published: March 2024

Background: The Spodoptera frugiperda, commonly known as the fall armyworm (FAW), is a significant pest impacting agricultural productivity worldwide. Originating from tropical and subtropical regions, FAW has shown a high capacity for migration and destruction across a wide variety of crops. Integrated Pest Management (IPM) strategies offer sustainable approaches to managing pest populations, minimizing environmental impact, and reducing reliance on chemical insecticides.
Objective: This study aimed to evaluate the efficacy of combining biological control agents, specifically Heterorhabditis bacteriophora (Hb) and Beauveria bassiana (Bb), with the chemical insecticide chlorantraniliprole (Ch) against third and fifth instar larvae of S. frugiperda. The study sought to determine the potential synergistic effects of these combinations on larval mortality and developmental disruption.
Methods: The research encompassed laboratory bioassays, greenhouse, and field trials to assess the impact of the biocontrol agents and chlorantraniliprole, both individually and in combination, on FAW larval mortality and development. Larval populations of S. frugiperda were collected and reared under controlled conditions. Treatments applied included Hb, Bb, Ch, Hb+Bb, Hb+Ch, Bb+Ch, and Hb+Bb+Ch. Mortality rates were recorded at 3, 5, and 7 days post-treatment, while developmental parameters were assessed through pupation rates, adult emergence, and egg eclosion percentages.
Results: The combined application of Hb, Bb, and Ch significantly increased mortality rates in both the third and fifth instar larvae compared to individual treatments, with the highest mortality observed in the Hb+Bb+Ch group (100% by day 7). Developmental disruptions were also noted, including reduced pupation rates, adult emergence, and egg eclosion, particularly in treatments involving the combined use of biocontrol agents and chlorantraniliprole. Statistical analysis confirmed the significance of these findings (P<0.01).
Conclusion: The integration of Hb, Bb, and Ch presents a viable IPM strategy for effectively managing S. frugiperda populations. This combination not only enhances larval mortality but also disrupts developmental stages, offering a potential reduction in FAW infestation levels and associated crop damages. These results underscore the importance of adopting sustainable pest management practices that leverage synergistic effects between biological and chemical agents.
Creative industries as a means of increasing the economic potential of the Dnipropetrov region (Ukraine)
Authors:   Rivne State University for the Humanities, Ukraine, Vytkalov Serhii , Shpakovska Marina ,   Rivne State University for the Humanities, Ukraine
Published: March 2024

The material of the article examines the evolution of creative industries in Ukraine, highlighting their growing role in both the economic and cultural spheres. A comprehensive analysis is presented that reveals the multi-level economic impact of these industries, including direct, indirect and induced effects, as well as their role in facilitating innovation and technological progress. These industries, according to the definition of the Ukrainian Government, cover 34 different types of economic activity, which significantly affects such sectors as IT, advertising and publishing. In 2020, their contribution to the economy of Ukraine was noticeable: they accounted for 4.2% of the added value and employed hundreds of thousands of workers. The multifaceted impact of creative industries on the economy of Ukraine is emphasized, including direct contributions to production and employment, as well as indirect impacts through supply and consumption chains, as well as their social and economic consequences. SWOT analysis and strategic recommendations provide insight into internal and external factors affecting these institutions, outline effective strategies for increasing competitiveness. The role of creative industries in the economic and cultural development of Ukraine is substantiated, their contribution to GDP, employment and exports, as well as their impact on society is emphasized.
Formation of the enterprise strategy in conditions of turbulence
Authors:   National University of Kyiv-Mohyla Academy, Ukraine, Soroka Viktoriia , Ignatieva Iryna ,   National University of Kyiv-Mohyla Academy, Ukraine
Published: March 2024

This article examines the development of business strategies for enterprises in turbulent environments, focusing on the Ukrainian business context. The author analyzes the economic conditions and challenges faced by Ukrainian enterprises during turbulence, providing practical advice and potential business strategies. Using an analytical approach, the study identifies strategies to mitigate risks and capitalize on opportunities. Emphasizing effective decision-making and resource allocation, the paper highlights the importance of longterm success in turbulent business environments. Despite various strategies available, the article recommends a thorough analysis of organizational strengths and weaknesses, considering the specificities of the business environment for an effective and tailored strategy that balances economic benefits with potential risks.
Peran Pendidikan Islam dalam Menghadapi Tantangan Sekularisme
Authors: Sidiq Hamid , Nurfitri Tetin , Syahidin Rif'at Ahmad
Published: March 2024

Islamic education in Indonesia today is faced with a challenge that seeks to separate religious affairs from worldly affairs, this ideology is secularism which seeks to spread an understanding among the world's younger generation. When this understanding has increasingly spread among the younger generation of Muslims, especially Islamic students in Indonesia, it is not impossible that the future values of Islamic teachings will lose their identity. To anticipate various bad possibilities among the younger generation of Indonesian Muslims, the role of Islamic education is very urgent to be implemented. This study used a qualitative research and the type of research used was library research. The data sources for this research are online scientific journals that discuss secularism. The data analysis technique in this study used the Miles and Huberman technique which was carried out in four stages, namely: reduction, presentation, and verification or validation. The results of this study indicate that Islamic education has a very urgent role to be implemented among the younger generation of Muslims in Indonesia. This role can be actualized through strong faith education, worship education, and moral education.
Kajian UMKM dalam Rangka Pemulihan Ekonomi Daerah Kabupaten Bogor Tahun 2021
Authors: Aqilla Fahira Nur
Published: March 2024

Keterlibatan UMKM dalam proses pembangunan ekonomi perlu dicermati, mengingat tingkat produktivitasnya harus terus dikembangkan disamping usaha besar. Namun, Covid-19 sangat berdampak pada berbagai sektor kehidupan, tidak sedikit pelaku UMKM terdampak yang kesulitan mengembangkan usahanya. Dalam rangka menumbuhkan kembali dan meningkatkan efektivitas UMKM perlu dilakukan terobosan baru agar roda ekonomi masyarakat dapat kembali berputar. Metode penelitian ini adalah metode kuantitatif dan kualitatif yang disajikan secara deskriptif dan eksploratif untuk menggambarkan hasil analisis. Teknik pengumpulan datanya dilakukan melalui penelusuran literatur, FGD, dan wawancara. Data dianalisis dengan menggunakan analisis data dasar saat ini (existing condition) dan analisis strategi daerah. Jumlah UMKM di Kabupaten Bogor terdata sebesar 12.556 unit usaha pada 40 kecamatan dari berbagai komoditas atau jenis usaha. Hasil penelitian menunjukkan pelaku UMKM dari pengolahan hasil perikanan memiliki potensi dari ragam produk yang bervariasi dan inovasif. Berbagai masalah dihadapi oleh UMKM pada masa pandemi Covid-19 seperti menurunnya daya beli konsumen, pemasaran, perizinan usaha karena masalah umum. Permasalahan lain yang sering dihadapi oleh pelaku UMKM adalah minimnya kualifikasi dan kompetensi SDM. Berbagai strategi yang dilakukan untuk menghadapi pandemi Covid-19 terutama pada sektor UMKM yaitu: 1) Kemudahan izin usaha; 2) Bantuan modal; 3) Perlindungan komoditas; 4) Pelatihan promosi dan pemasaran digital; 5) Pelatihan kompetensi SDM.
Analisis Komponen Pertumbuhan Ekonomi Kabupaten Bogor Periode 2016-2019
Authors: Hakim Dedi Budiman , Hadianto Adi , Panjaitan Dian Verawati
Published: March 2024

Penetapan sektor prioritas penting dilakukan untuk mengetahui kebijakan khusus yang diperlukan untuk mendukung pembangunan ekonomi. Oleh karena itu, kebijakan tersebut dapat diterapkan secara efektif. Penelitian ini bertujuan untuk menentukan sektor-sektor basis dengan menggunakan model Location Quotient (LQ) dan untuk mengidentifikasi komponen-komponen pertumbuhan ekonomi dengan menggunakan analisis Tipologi Klassen dan Shift Share (SS). Hasil analisis menunjukkan bahwa sektor basis di Kabupaten Bogor adalah Sektor pertanian, kehutanan, dan perikanan, pertambangan, industri pengolahan, penyediaan air, pengelolaan limbah, dan limbah dan daur ulang memainkan peran yang sangat penting dalam pembangunan ekonomi. Dua komponen dominan yang menentukan pertumbuhan ekonomi adalah faktor wilayah (perekonomian Provinsi Jawa Barat) dan keunggulan kompetitif beberapa sektor di Kabupaten Bogor. Pemerintah dapat fokus pada sektor-sektor utama dengan menetapkan instrumen fiskal yang memberikan dampak berganda terhadap perekonomian Kabupaten Bogor.
INOVASI PENILAIAN PEMBELAJARAN MELALUI APLIKASI RAPOR DIGITAL MADRASAH (RDM) DI MI ISLAMIYAH SYAFIIYAH GANDRIROJO
Authors: Yusuf Khoiril Anwar  , Syifaul Khoir
Published: March 2024

Penilaian pembelajaran sebagai pertimbangan proses pembelajaran, laporan kepada orang tua dapat dilaksanakan dengan menggunakan berbagai cara. Salah satu cara yang bisa digunakan adalah memanfaatkan perkembangan teknologi berupa Rapor Digital Madrasah (RDM). Sebagai aplikasi yang baru diluncurkan dan terbatas pada madrasah dibawah naungan Kementerian Agama Republik Indonesia saja, RDM masih memiliki beberapa kendala dalam pengoperasiannya, salah satunya adalah faktor sumberdaya manusia. Penelitian ini bertujuan untuk mengetahui inovasi penilaian pembelajaran melalui aplikasi RDM di lingkup Madrasah Ibtidaiyah. Jenis penelitian ini adalah kualitatif dengan desain deskriptif. Lokasi penelitian ini adalah MI Islamiyah Syafiiyah Gadrirojo. Subjek penelitian ini elemen madrasah yang memupunyai kepentingan dalam proses penilaian hasil belajar. Objek penelitian ini adalah inovasi dalam penilaian pembelajaran melalui RDM. Hasil dari penelitian ini adalah inovasi yang dilakukan dalam penilaian pembelajaran melalui RDM dengan menyediakan blangko penilaian sesuai tampilan aplikasi RDM serta membuat tahapan dalam pengoperasian RDM yang diikuti oleh seluruh guru, kepala sekolah dan operator madrasah.
Joint Extraction of Entities and Relations Based on Multi-feature Fusion
Authors: Li Shoubin , Chang Zhiyuan , Liu Yangyang
Published: March 2024

Joint extraction of entities and relations is essential for understanding massive text corpora. In recent years, the span-based joint models have achieved excellent results in the entity and relation extraction task. However, the previous literature and experimental results suggest that the usage of span-based method in entity and relation extraction may produce more redundant entities, although it can solve the overlapping problem of entities. In order to solve the problem of entity redundancy, this paper proposes a joint extraction model based on multi-feature fusion. The overall network follows the framework as SpERT, which is the state-of-the-art model for joint entity and relation extraction. In addition to the word embedding features in SpERT, the proposed model also considers the part-of-speech features. We believe that the part-of-speech features in entities are helpful for entity recognition and can effectively alleviate the entity redundancy problem. The proposed model is evaluated on two public data sets, CoNLL04 and ADE. The experimental results show that the proposed joint extraction model based on multi-feature fusion significantly outperforms current state-of-the-art methods.
PENGARUH TRUST TERHADAP KINERJA KARYAWAN DENGAN ETIKA KERJA ISLAM SEBAGAI VARIABEL MODERATING
Authors: Arbaan  , Manyur Addury Multazam
Published: March 2024

Penelitian ini bertujuan untuk meneliti pengaruh trust terhadap kinerja karyawan menggunakan etika kerja islami sebagai variabel moderator. Penelitian ini dilakukan pada karyawan lembaga keuangan syariah di Yogyakarta. Sampel dalam penelitian ini adalah karyawan yang bekerja pada lembaga keuangan syariah di Daerah Istimewa Yogyakarta dengan jumlah 70 orang responden. Teknik analisis data untuk mengetahui pengaruh trust terhadap kinerja dengan etika kerja Islam sebagai variabel moderasi  adalah dengan menggunakan analisis hipotesis dengan metode MRA (Moderate Regrestion Analysis) yang kemudian akan diketahui hasilnya. Berdasarkan analisis hipotesis dengan metode MRA (Moderate Regrestion Analysis) dalam penelitian ini, telah diperoleh hasil bahwa variabel trust memiliki pengaruh sebesar 70,9% terhadap variabel kinerja sebelum dimoderasi variabel etika kerja Islam dan sisanya atau sebesar 29,1% dipengaruhi oleh variabel lain. Setelah dimoderasi oleh variabel etika kerja Islam, pengaruh hubungan variabel trust terhadap variabel kinerja meningkat menjadi 74,2% dan bernilai positif dengan signifikansi sebesar 0,034, sisanya sebesar 25,8% dipengaruhi oleh variabel lain. Dengan demikian, maka dapat disimpulkan bahwa variabel moderasi pada penelitian ini (etika kerja Islam) berperan sebagai penguat hubungan antara variabel independen (trust) dengan variabel dependen (kinerja).
PENGARUH MODAL SOSIAL, KEARIFAN LOKAL, RELIGIUSITAS DAN FAKTOR EKONOMI TERHADAP KEPATUHAN SYARIAH PARA NASABAH PEMBIAYAAN PADA BANK PEMBIAYAAN RAKYAT SYARIAH (BPRS) DI YOGYAKARTA
Authors: Muhamad
Published: March 2024

Rumusan masalah dalam penelitian ini adalah: (1) Bagaimana kondisi modal sosial, pengetahuan lokal dan faktor ekonomi, dan kepatuhan syariah pembiayaan nasabah pada BPRS di Yogyakarta, (2) Apakah faktor modal sosial, pengetahuan lokal dan ekonomi yang mempengaruhi kepatuhan syariah pembiayaan nasabah, di BPRS di Yogyakarta? Tujuan penelitian ini adalah (1) Mengetahui kondisi modal sosial, kearifan lokal dan faktor ekonomi serta kepatuhan syariah pembiayaan nasabah pada BPRS di Yogyakarta, (2) Membuktikan secara empiris dan menganalisis pengaruh modal sosial, kearifan lokal dan faktor ekonomi terhadap kepatuhan nasabah pembiayaan syariah pada BPRS di Yogyakarta. Berdasarkan hasil analisis analisis regresi dalam penelitian, dapat disimpulkan sebagai berikut: (1) variabel-variabel yang dapat mempengaruhi tumbuhnya kepatuhan Syariah pada pembiayaan nasabah BPRS di Yogyakarta, dalam penelitian ini, adalah: modal sosial, kearifan lokal, religiusitas dan faktor ekonomi, (2) Terdapat pengaruh yang signifikan secara bersama-sama modal sosial, kearifan lokal, religiusitas, faktor ekonomi terhadap kepatuhan nasabah pembiayaan syariah BPRS di Yogyakarta, (3) Pengaruh modal sosial, kearifan lokal, religiusitas, faktor ekonomi terhadap kepatuhan nasabah pembiayaan syariah BPRS di Yogyakarta adalah sebesar 0,249. Artinya, sedangkan sisanya 75,1% dijelaskan oleh penyebab lain di luar model penelitian. Penyebab lainnya antara lain: situasi eksternal pelanggan, kondisi sosial ekonomi (seperti kenaikan BBM, tarif listrik, dll), kondisi politik (seperti pergantian Kepala Daerah, dll), dan regulasi (seperti perubahan/kenaikan suku bunga SBI, dll).
Pemberdayaan Petani Melalui Program Reboisasi Penanaman Tanaman Keras. di Desa Giricahyo, Panggang, Gunung Kidul Yogyakarta
Authors: Istiqomawati Rina , Widiyastuti Andriyani , Priyono Susilo
Published: March 2024

Perbukitan daearah gunung kidul adalah kawasan yang rawan longsor. Hal ini perlu di adakan upaya dalam penanggulangan tanah longsor tersebut, diantaranya adalah reboisasi/ penghijauan dengan tanaman keras.  Tanaman keras selain untuk penghijauan juga bisa untuk keindahan dan bisa untuk mengurangi terjadinya tanah longsor. Tanaman keras itu  diantaranya adalah : akasia , sengon laut, jambu mete, alpukat. Program penghijauan yang dilakukan di Gunung Kidul itu melibatkann bergabai pihak diantaranya adalah, pemerintah, STEI Yogyakarta dan warga sekitar khususnya petani.  Penghijauan yang dilaksanakan  itu selain menambah keindahan, penanggulangan tanah longsor juga bisa memberikan manfaat peningkatan ekonomis  bagi warga sekitar khususnya petani. Potensi masyarakat dan  sumberdaya petani  di desa Giri cahyo, Kecamatan Panggang , kabupaten Gunung Kidul perlu disikapi dengan suatu pelatihan  yang melibatkan Petani  dalam memanfaatkan dan mengelola lingkungan sekitar melalui budidaya aneka jenis tanaman . Pelatihan dalam kegiatan pengabdian pada masyarakat ini ini bertujuan untuk: (1) Meningkatkan pengetahuan Petani di desa Giri cahyo tentang Tanaman keras  yang bermanfaat dbagi peningkatan ekonomi, dan (2) Memberdayakan petani dalam pemanfaatan sumberdaya perdesaan berupa budidaya Tanaman Keras dan tanaman lainnya.
     Kegiatan pengabdian dilakukan dengan metode ceramah dan demonstrasi. Metode ceramah untuk menjelaskan tentang kajian sumberdaya perdesaan, pemanfaatan sumberdaya perdesaan berupa tanaman Keras dan Tanaman lain.  Pemberdayaan petani dalam budidaya Tanaman keras dan  yang dapat mencegah erosi dan tanah longsor  dan mempunyai nilai jual ekonomis. Metode demonstrasi juga dilakukan untuk mempraktekkan tata cara bertanam, memelihara, dan mengelola Tanaman Keras.
      Kegiatan pengabdian masyarakat ini  secara keseluruhan dapat dikatakan baik dan berhasil, dilihat dari keberhasilan target jumlah peserta pelatihan (100 persen), ketercapaian tujuan pelatihan (75 persen), ketercapaian target materi yang telah direncanakan (80 persen), dan kemampuan peserta dalam penguasaan materi (75 persen).
Proses Pembuatan Pupuk Organik Padat (POP) Kotoran Kambing dengan metode Fermentasi di desa Giriasih, Purwosari Gunung Kidul
Authors: Widianti Emma
Published: March 2024

Pertanian organik merupakan sistem pertanian yang pada mulanya digalakkan setelah terdapat dampak-dampak negatif yang timbul akibat pelaksanaan revolusi hijau dengan memanfaatkan masukan (input) berbahan kimia yang menimbulkan beberapa dampak negatif yaitu kerusakan lingkungan, cemaran residu kimia, penurunan keanekaragaman hayati, penurunan produktivitas, dan kemunduran kesuburan lahan. Pupuk organik merupakan pupuk yang berasal dari berbagai bahan pembuat pupuk alami seperti kotoran hewan, bagian tubuh hewan, tumbuhan, yang kaya akan mineral serta baik untuk pemanfaatan penyuburan tanah.      
Hasil dari kegiatan pelatihan pembuatan pupuk organik padat yaitu edukasi petani tentang proses fermentasi pada pupuk kotoran kambing dalam menguraikan bahan-bahan organik yang terkandung dalam kotoran kambing untuk dijadikan sebagai sumber unsur-unsur hara yang stabil dan lebih mudah diserap oleh tanaman daripada pupuk organik yang tidak difermentasi, dapat menjadikan tanaman tumbuh lebih subur serta proses partumbuhan dan perkembangannya juga lebih cepat serta menambah nilai manfaat ekonomis bagi masyarakat setempat
Pembinaan dan Pemberdayaan Pembatik Desa Girirejo Imogiri Bantul, Membangun Kembali Industri Batik Desa Girirejo Imogiri Bantul D.I. Yogyakarta
Authors: Baskoro Windu , Widiastuti Andriyani
Published: March 2024

Desa Girirejo, Imogiri, Bantul merupakan sebuah desa yang dulunya merupakan sentra industri Batik di Yogyakarta (1960 – 1980), namun masih memiliki pembatik dan peralatan yang masih berpotensi untuk dihidupkan dan kembangkan kembali. Tujuan pengabdian masyarakat ini adalah menghidupkan kembali industri batik di desa Girirejo. Program Pengabdian menggunakan pendekatan atau Metoda PRA (Participatory Rural Appraisal). Beberapa teknik dan kegiatan dalam PRA antara lain, FGD (Focus Discussion Group), pemetaan sumber daya, workshop pembatikan serta evaluasi kinerja. Hasil dari Pengabdian masyarakat 1) Kesepakatan tim pengabdian, pembatik dan pemerintah desa untuk  menghidupkan kembali industri batik , 2) Mendokumentasikan 45 alat cap batik dan  merehabilitasi  3) Mendokumentasikan 25 motif batik tulis klasik dan merekonstruksi 4 motif batk tulis, 4) Workshop pembatikan selama 2 hari, tentang design motif batik tulis dan cap dan pewarnaan alami dan sintetis. Hasil program pengabdian ini telah memberikan pondasi awal untuk menghidupkan kembali industri batik di desa Girirejo, Imogiri Bantul yang perlu ditindaklanjuti dengan program penguatan
Hammerhead-type FXR agonists induce an eRNA FincoR that ameliorates nonalcoholic steatohepatitis in mice
Authors: Chen Jinjing , Wang Ruoyu , Xiong Feng , Sun Hao , Kemper Byron , Li Wenbo , Kemper Jongsook Kim
Published: March 2024

The nuclear receptor, Farnesoid X Receptor (FXR/NR1H4), is increasingly recognized as a promising drug target for metabolic diseases, including nonalcoholic steatohepatitis (NASH). Protein coding genes regulated by FXR are well known, but whether FXR also acts through regulation of long non-coding RNAs (lncRNAs), which vastly outnumber protein-coding genes, remains unknown. Utilizing RNA-seq and GRO-seq analyses in mouse liver, we found that FXR activation affects the expression of many RNA transcripts from chromatin regions bearing enhancer features. Among these we discovered a previously unannotated liver-enriched enhancer-derived lncRNA (eRNA), termed
FincoR
. We show that
FincoR
is specifically induced by the hammerhead-type FXR agonists, including GW4064 and tropifexor. CRISPR/Cas9-mediated liver-specific knockdown of
FincoR
in dietary NASH mice reduced the beneficial effects of tropifexor, an FXR agonist currently in clinical trials for NASH and primary biliary cholangitis (PBC), indicating that that amelioration of liver fibrosis and inflammation in NASH treatment by tropifexor is mediated in part by
FincoR
. Overall, our findings highlight that pharmacological activation of FXR by hammerhead-type agonists induces a novel eRNA,
FincoR
, contributing to the amelioration of NASH in mice.
FincoR
may represent a new drug target for addressing metabolic disorders, including NASH.
Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome
Authors: Cheong Han SJ , Eichler Katharina , Stürner Tomke , Asinof Samuel K , Champion Andrew S , Marin Elizabeth C , Oram Tess B , Sumathipala Marissa , Venkatasubramanian Lalanti , Namiki Shigehiro , Siwanowicz Igor , Costa Marta , Berg Stuart ,   Janelia FlyEM Project Team, Jefferis Gregory SXE , Card Gwyneth M
Published: March 2024

In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor neurons (MNs) in the nerve cord of the animal’s body that effect movement of the limbs. To understand how brain signals generate behavior, it is critical to understand how these descending pathways are organized onto the body MNs. In the fly,
Drosophila melanogaster
, MNs controlling muscles in the leg, wing, and other motor systems reside in a ventral nerve cord (VNC), analogous to the mammalian spinal cord. In companion papers, we introduced a densely-reconstructed connectome of the
Drosophila
Male Adult Nerve Cord (MANC, Takemura et al., 2023), including cell type and developmental lineage annotation (Marin et al., 2023), which provides complete VNC connectivity at synaptic resolution. Here, we present a first look at the organization of the VNC networks connecting DNs to MNs based on this new connectome information. We proofread and curated all DNs and MNs to ensure accuracy and reliability, then systematically matched DN axon terminals and MN dendrites with light microscopy data to link their VNC morphology with their brain inputs or muscle targets. We report both broad organizational patterns of the entire network and fine-scale analysis of selected circuits of interest. We discover that direct DN-MN connections are infrequent and identify communities of intrinsic neurons linked to control of different motor systems, including putative ventral circuits for walking, dorsal circuits for flight steering and power generation, and intermediate circuits in the lower tectulum for coordinated action of wings and legs. Our analysis generates hypotheses for future functional experiments and, together with the MANC connectome, empowers others to investigate these and other circuits of the
Drosophila
ventral nerve cord in richer mechanistic detail.
Anti-ENO1 antibody combined with metformin against tumor resistance: a novel antibody-based platform
Authors: Shu Xiong , Zhang Hui Wen , Liu Shi Ya , Sun Li Xin , Zhang Tao , Ran Yu Liang
Published: March 2024

Background

Antibody-based platforms (i.e., ADC) have emerged as one of the most encouraging tools for the cancer resistance caused by cancer stem cells (CSCs) enrichment. Our study might provide a promising therapeutic direction against drug resistance and serve as a potential precursor platform for screening ADC.

Methods

The cell migration, invasion, drug resistance, and self-renewal were assessed by the cell invasion and migration assay, wound healing assay, CCK-8 assay, colony formation assay, and sphere formation assay, respectively. The expression profiles of CSCs (ALDH+ and CD44+) subpopulations were screened by flow cytometry. The western blot and cell immunofluorescence assay were used to evaluate pathway-related protein expression in both anti-ENO1 antibody, MET combined with DPP/CTX-treated CSCs.

Results

In the present study, western blot and flow cytometry verified that anti-ENO1 antibody target the CD44+ subpopulation by inhibiting the PI3K/AKT pathway, while metformin might target the ALDH+ subpopulation through activation of the AMPK pathway and thus reverse drug resistance to varying degrees. Subsequently, in vitro investigation indicated that anti-ENO1 antibody, metformin combined with cisplatin/cetuximab could simultaneously target ALDH+ and CD44+ subpopulations. The combination also inhibited the CSCs proliferation, migration, invasion, and sphere formation; which may result in overcoming the drug resistance. Then, molecular mechanism exploration verified that the anti-ENO1 antibody, metformin combined with cisplatin/cetuximab inhibited the Wnt/β-catenin signaling.

Conclusions

The study preliminarily revealed anti-ENO1 antibody combined with metformin could overcome drug resistance against CSCs by inhibiting the Wnt//β-catenin pathway and might serve as a potential precursor platform for screening ADC. More importantly, it is reasonably believed that antibody-based drug combination therapy might function as an encouraging tool for oncotherapy.
Lived Experiences of Health Workers from the Caraga Regional Hospital (CRH) in Times of Covid-19 Pandemic
Authors: Platil Grace
Published: March 2024

This study intends to unfold the lived experiences of the health workers from the Caraga Regional Hospital (CRH) during the outrage of the COVID-19 pandemic. A total of five (5) medical doctors, five (5) nurses, and five (5) non-medical staff were subjected to Focus Group Discussions (FGD). Results showed that health workers have different experiences in terms of health benefits. Although the majority of the respondents were able to avail sufficient benefits, some health workers considered the benefits delayed and insufficient. Poor and delayed logistics support during the early years of the pandemic was also encountered. In terms of feelings towards their employer, the majority of the respondents are highly satisfied, while they have expressed feelings of discomfort towards the job. Common difficulties experienced by the health workers include negative social impressions, weariness and discomfort towards the family's safety, and insufficient medical supplies and workforce. On a positive note, the coping strategies of the health workers are strong adherence to safety and health protocols, optimism towards the situation, and quality conversation with psychology experts, friends, and families. These findings are significant inputs to CRH management for planning and better human resource management.
Assessment of Philippine Integrated Management of Acute Malnutrition (PIMAM) Program Implementation and Challenges in Maguindanao Hospitals, Philippines
Authors: Abdulrahman Saed , Bagolong Saidamin
Published: March 2024

This study aimed to evaluate the implementation of the Philippine Integrated Management of Acute Malnutrition (PIMAM) Program in Maguindanao Provincial Hospital (MPH), Dinaig Municipal Hospital (DMH), and South Upi Municipal Hospital (SUMH), Philippines. Employing a descriptive-evaluative design, data were gathered from 107 respondents comprising top management and hospital staff, selected via purposive sampling. A survey questionnaire was utilized as the primary data collection tool, supplemented by secondary data obtained from hospitals' PIMAM-ITP coordinators regarding the status of patients upon discharge from the Inpatient Therapeutic Program (ITP). Data were analyzed using mean and percentage. Results indicated high levels of implementation of PIMAM-ITP across the hospitals concerning guidelines, facilities, materials, screening, treatment, and discharge procedures. Notably, 74% of discharged patients from ITP hospitals were classified as "successfully treated," with the remaining categorized as defaulter (16%), deceased (8%), medically transferred (2%), or non-respondent (0%). The program demonstrated effectiveness in systematically addressing acute malnutrition. However, challenges persisted, particularly concerning caregiver compliance and funding allocation for training on the National Guidelines for the Management of Severe Acute Malnutrition among personnel involved in program implementation.
Implementation of Nursing Service Operations in Maguindanao Provincial Hospital, Philippines
Authors: Uda Ryan , Bagolong Saidamin
Published: March 2024

With the increasing dimension of medical sciences, nursing care is becoming more and more complex with its management services. This study aimed to evaluate the implementation of Nursing Service Operations in Maguindanao Provincial Hospital in terms of Emergency Room and In-patient services, the processes followed in terms of Triaging, Profiling, Admission, Treatment, and Discharging, and the patients’ status such as Admission to Ward and Discharge from Care. The study utilized a descriptive-evaluative method using a researcher-made survey questionnaire to 255 respondents comprising 107 hospital staff and 148 discharged patients. Data were analyzed using the weighted mean. Results revealed that Emergency Room (ER) and In-patient services were highly implemented. There was a very high implementation process for nursing services for triaging, profiling, treatment, and discharge, except for a high admission process. Also, the patient’s status regarding admission to the ward for emergency room services was high, while discharge from care for in-patient services was moderate. Regarding problems encountered, it was revealed that the MPH needed more staffed nurses, cultural health beliefs, language barriers, lack of continuous education, delayed salary, etc. Hence, the Maguindanao Provincial Hospital adhered to the guidelines in the DOH Administrative Order 2012-0012; however, certain provisions must be complied with to deliver emergency room and in-patient services effectively and efficiently.
Population Dynamics of Fall Armyworm, Spodoptera frugiperda and its Natural Enimies in Maize
Authors: Darshan R  , Prasanna P M  , Guruprasad G S  , Hegde Jayalaxmi Narayan
Published: March 2024

Fall armyworm (Spodoptera frugiperda) is one of the polyphagous invasive insect to India, initially reported from Karnataka. A roving survey was conducted during two cropping seasons at fortnightly interval at kharif and rabi of 2019-2020 to know the status of the pest in Haveri district. The results revealed that the mean larval population and per cent infestation of fall armyworm was ranged from 0.30 to 0.44 larvae per plant and 23.10 to 33.77 per cent, respectively. In the study period, parasitisation by two larval parasitoids viz., Campoletis chlorideae (Hymenoptera: Ichneumonidae) and Exorista xanthaspis (Diptera: Tachinidae) and infection by an entomopathogenic fungi, Metarhizium rileyi were also observed. The rainfall (r = -0.889) was only parameter having significantly negative influence on pest incidence.
Locus of Control Internal vs External: The Role in the Relationship between Work-Family Conflict and Job Stress
Authors: Indriani Yayuk , Wahyuningsih Sri Handari , Qamari Ika Nurul
Published: March 2024

This study aims to investigate the role of personality factor, locus of control, as a moderator in the relationship between work-family conflict and stress. It is hypothesized that an internal locus of control may diminish the impact of work-family conflict on job stress. The research sample consisted of 110 employees from the Ministry of Cooperative and SMEs. Primary data were collected by distributing questionnaires to selected respondents. The practical implications of this study can provide valuable insights to the leadership at the Ministry of Cooperative and SMEs regarding the impact of work-family conflict on employees' stress levels, thus offering considerations to alleviate this influence.
A comunidade LGBTQI+ como objeto de consumo
Authors: Nascimento Isaac Marlon Vasconcelos do , De Oliveira Vinícius Érbethe Freitas , Leite Junior Francisco Franciente
Published: March 2024

O presente artigo busca trazer à tona um entendimento a partir de um estudo bibliográfico no que diz respeito à prática do “Pink Marketing” ou “Pink Money” (dinheiro rosa), que é definida segundo Moreschi, Martins e Craveiro (2011) como “dinheiro advindo do mercado gay”, referindo-se ao consumo e à tática comercial como estratégia de marketing para com membros da comunidade LGBTQI+. Este estudo objetiva também relacionar essa prática com os impactos psicossociais para esta população em geral. Para isto, o artigo conta com a colaboração teórica de pesquisadores que tomam o gênero como objeto de estudos, localizados em bases digitais na forma de artigos científicos em português, escritos geralmente por autores representantes de diversas causas sociais, sendo geralmente estudos bibliográficos acerca do tema. Realizamos, metodologicamente, a relação entre a hipótese levantada sobre quais impactos sociais a prática do Pink Money produz com os artigos selecionados. Os resultados aparecerem como conclusão, que vão desde a percepção do consumidor LGBTQI+, sendo alguns alienados, outros ativos e protestantes contra a prática, até as entidades usuárias da estratégia, como aproveitadores da população minoritária para fins lucrativos.
Occupation and adult‐onset asthma among chinese women in a population‐based cohort
Authors: Krstev Srmena , Ji Bu‐Tian , Shu Xiao‐Ou , Blair Aaron , Zheng Wei , Lubin Jay , Vermeulen Roel , Hauptmann Michael , Rothman Nathaniel , Gao Yu‐Tang , Mustafa Dosemeci , Chow Wong‐Ho
Published: February 2007

Background

Exposure to industrial irritants is believed to have contributed to the increasing prevalence of asthma worldwide. We examined the associations between occupation and asthma among women in a case‐control study nested in the population‐based Shanghai Women's Health Study cohort in China.

Methods

Cases were 1,050 women who reported a physician‐diagnosed asthma as adults. Controls were 4,200 women matched to the cases by year of birth and age at diagnosis. Lifetime occupational histories were obtained. Logistic regression was applied to estimate odds ratios (ORs) adjusting for smoking, education, family income, and concurrent chronic bronchitis.

Results

Asthma is more prevalent in production industries for metal tools (OR = 2.4; 1.3–4.7), metal products for everyday use (OR = 1.6; 1.1–2.4), ships (OR = 2.6; 1.0–6.8), and clocks (OR = 1.9; 1.0–3.4), and in occupations as farm workers (OR = 4.0; 1.2–13.0), laboratory technicians and analyzers (OR = 2.2; 1.2‐3.9), and installation and maintenance workers for weaving and knitting machineries (OR = 2.4; 1.1–5.4). Other associations less commonly reported were identified for electricians (OR = 2.1; 1.1–4.1), performers (OR = 3.2; 1.4–7.4), administrative workers in organizations and enterprises (OR = 1.8; 1.1–2.8), and postal and telecommunication workers (OR = 3.5; 1.6–7.6).

Conclusions

Our findings suggest that occupational exposures contribute to the development of asthma in women. Am. J. Ind. Med. 2007. © 2007 Wiley‐Liss, Inc.
Informing prospective research subjects of the influence of regulatory requirements for drug approval on the design of clinical trials in oncology
Authors: Markman Maurie
Published: February 2007

An established tenet of ethical clinical research stipulates that individuals considered for entry into therapeutic trials must be provided with all data that might influence their decision. However, discussion in the literature regarding the investigators' responsibility to inform possible participants about the nature and impact of regulatory requirements on the studies' design has been limited. Three examples are discussed, which illustrate the ethical concerns that might result from the failure of clinical researchers to fully inform patients.
Survivin expression is associated with bladder cancer presence, stage, progression, and mortality
Authors: Shariat Shahrokh F. , Ashfaq Raheela , Karakiewicz Pierre I. , Saeedi Osamah , Sagalowsky Arthur I. , Lotan Yair
Published: February 2007

BACKGROUND

The purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes.

METHODS

Immunohistochemical staining for Survivin was carried out on archival bladder specimens from 9 normal controls and 222 consecutive patients who underwent radical cystectomy and bilateral lymphadenectomy. Lymph node tissue involved with TCC from 50 of the 222 cystectomy patients was also evaluated.

RESULTS

Survivin was expressed in none of the normal bladder specimens, 64% of the cystectomy specimens, and 94% of the malignant lymph nodes. Multivariable analyses performed in the cystectomy patients revealed that Survivin expression was associated with disease recurrence (P = .040), disease‐specific mortality (P = .037), and all‐cause mortality (P = .044).

CONCLUSIONS

The findings of the study provide a rationale for further evaluation of Survivin and its downstream signaling pathways in bladder cancer and raise the potential for Survivin‐targeted therapy for bladder cancer. Cancer 2007. © 2007 American Cancer Society.
Obesity is associated with increased risks of prostate cancer metastasis and death after initial cancer diagnosis in middle‐aged men
Authors: Gong Zhihong , Agalliu Ilir , Lin Daniel W. , Stanford Janet L. , Kristal Alan R.
Published: February 2007

BACKGROUND

Current research is inconclusive regarding the effect of obesity on outcomes after a prostate cancer diagnosis. The objective of this study was to examine associations between obesity and the risks of developing metastasis or prostate cancer‐specific mortality in a population‐based cohort of men with prostate cancer.

METHODS

Seven hundred fifty‐two middle‐aged men with prostate cancer who were enrolled in a case‐control study and remain under long‐term follow‐up for disease progression and mortality formed the study cohort. Body mass index (BMI) in the year before diagnosis was obtained at the time of initial interview. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) of prostate cancer metastasis and mortality associated with obesity, controlling for age, race, smoking status, Gleason score, stage at diagnosis, diagnostic prostate‐specific antigen level, and primary treatment.

RESULTS

Obesity (BMI ≥30 kg/m2) was associated with a significant increase in prostate cancer mortality (HR, 2.64; 95% CI, 1.18–5.92). Among men who were diagnosed with local‐ or regional‐stage disease, obesity also was associated with an increased risk of developing metastasis (HR, 3.61; 95% CI, 1.73–7.51). Associations generally were consistent across strata defined by Gleason score (2–6 or 7 [3 + 4] vs 7 [4 + 3] or 8–10), stage (local vs regional/distant for mortality), and primary treatment (androgen‐deprivation therapy use: yes vs no).

CONCLUSIONS

Obesity at the time of diagnosis was associated with increased risks of prostate cancer metastasis and death. The increased risk of prostate cancer death or metastasis associated with obesity largely was independent of key clinical prognostic factors at diagnosis. Cancer 2007. © 2007 American Cancer Society.
Neurotrophic effects of GM1 ganglioside and electrical stimulation on cochlear spiral ganglion neurons in cats deafened as neonates
Authors: Leake Patricia A. , Hradek Gary T. , Vollmer Maike , Rebscher Stephen J.
Published: February 2007

Previous studies have shown that electrical stimulation of the cochlea by a cochlear implant promotes increased survival of spiral ganglion (SG) neurons in animals deafened early in life (Leake et al. [1999] J Comp Neurol 412:543–562). However, electrical stimulation only partially prevents SG degeneration after deafening and other neurotrophic agents that may be used along with an implant are of great interest. GM1 ganglioside is a glycosphingolipid that has been reported to be beneficial in treating stroke, spinal cord injuries, and Alzheimer's disease. GM1 activates trkB signaling and potentiates neurotrophins, and exogenous administration of GM1 has been shown to reduce SG degeneration after hearing loss. In the present study, animals were deafened as neonates and received daily injections of GM1, beginning either at birth or after animals were deafened and continuing until the time of cochlear implantation. GM1‐treated and deafened control groups were examined at 7–8 weeks of age; additional GM1 and no‐GM1 deafened control groups received a cochlear implant at 7–8 weeks of age and at least 6 months of unilateral electrical stimulation. Electrical stimulation elicited a significant trophic effect in both the GM1 group and the no‐GM1 group as compared to the contralateral, nonstimulated ears. The results also demonstrated a modest initial improvement in SG density with GM1 treatment, which was maintained by and additive with the trophic effect of subsequent electrical stimulation. However, in the deafened ears contralateral to the implant SG soma size was severely reduced several months after withdrawal of GM1 in the absence of electrical activation. J. Comp. Neurol. 501:837–853, 2007. © 2007 Wiley‐Liss, Inc.