bluuebunny/crossref_metadata_2025 huggingface dataset:
Sports Medicine Roundtable: When Ankle Sprains Take Longer Than Expected to Recover
Authors: Cloutier Dagan , McKinnon Kayla M. , Dowell Charles , Downie Brian , Collins Larry
Published: December 2019

The purpose of JOPA roundtable discussions is to give orthopaedic physician assistants (PAs) insight on how each participating editorial board member would treat certain clinical scenarios at their current practice. For this Sports Medicine Roundtable, JOPA editorial board members will discuss a case involving a 35-year-old man who presents with a persistently painful ankle sprain despite 8 weeks of conservative treatment. This case highlights how complications associated with ankle sprains can prolong the expected recovery time.
Analysis of the State of the Road Traffic Safety in the Republic of Kazakhstan
Authors: Ibrayev K. , Ibrayev A. , Kapskiy D. , Kot Y. , Rybinskiy A. , Bogdanovich S.
Published: December 2019

The article presents the results of the study of the road traffic safety on the automobile roads of the Republic of Kazakhstan. We performed the analysis of the main indicators, specifying the state of the road traffic safety on the automobile roads of the republican significance of the Republic of Kazakhstan. In many regulatory acts, such as “The Priority Action Plan for Improving the Road Traffic Safety of the Republic of Kazakhstan for 2017–2020”, developed with the support of the Asian Development Bank, and in the “National Concept of Road Traffic Safety” project as well , developed by the Interdepartmental Research Institute called “The Academy of Law Enforcement Agencies” of the General Prosecutor’s Office of the Republic of Kazakhstan, the urgent need to improve road traffic safety is clearly pointed. At the same time, it is necessary to have the information about the extent of the existing problem in the field of road traffic safety, which is ensured by the constant consideration and analysis of the statistical indicators, as well as by planning appropriate measures aimed at correcting the situation and achieving planned indicators in the framework of, for example, the national concept of road traffic safety. Currently, statistics on road traffic accidents, occurring in Kazakhstan, are published by the Committee on Statistics of the Republic of Kazakhstan and the Committee on Legal Statistics and Special Accounting. However in the current situation, this is not enough, especially since the ARC MIID of the Republic of Kazakhstan outlined the program of actions aimed at eliminating the existing shortcomings in the field of the road traffic safety and significant improving its indicators. The analytical investigation of the status of the road traffic safety on the roads of the Republic of Kazakhstan was carried out. This will become a kind of starting point in the consistent work in this direction, which will provide the interested parties, first of all the experts, with the high-quality and reliable information about the main figures, characterizing the state of safety of the road users. Based on objective accident data, it is possible to take the effective measures aimed at improving the situation on the roads of the Republic of Kazakhstan.
Desigualdades en el acceso a servicios, base de las políticas para la reducción de la brecha en salud
Authors: Gutiérrez Juan Pablo , Heredia-Pi Ileana , Hernández-Serrato María Isidra , Pelcastre-Villafuerte Blanca Estela , Torres-Pereda Pilar , Reyes-Morales Hortensia
Published: December 2019

Objetivo. Estimar la desigualdad en acceso a servicios de salud en poblaciones de localidades menores de 100 000 habitantes en México. Material y métodos. Análisis de la Encuesta Nacional de Salud y Nutrición 100k 2018. Se estimó el acceso con base en la afiliación a un esquema de aseguramiento (acceso potencial) y la atención para el más reciente problema de salud (acceso a atención) mediante el índice de concentración, utilizando una imputación del ingreso per cápita. Resultados. La afiliación a algún esquema de ase­guramiento en salud fue de 82.42% y el acceso a atención de 60.03%. Se identificaron desigualdades en ambos indicadores, marginales para acceso potencial y con mayor concentración entre la población de menor ingreso; para acceso a atención se encontró desigualdad con mayor concentración entre la población de mayor ingreso. Conclusión. En México pre­valecen desigualdades en acceso a servicios de salud para la población en condiciones de pobreza. Es necesario desarrollar intervenciones públicas con mayor granularidad para incidir de forma efectiva en la desigualdad.
Tendencias en la prevalencia de IRA y EDA en la primera infancia y factores asociados: Ensanut 2012 y 100k
Authors: Escamilla-Núñez Consuelo , Delgado-Sánchez Guadalupe , Castro-Porras Lilia V , Ferreira-Guerrero Elizabeth , Hernández-Cadena Leticia , Mongua-Rodríguez Norma , Flores-Luna Lourdes , Ferreyra-Reyes Leticia , Rojas-Martínez Rosalba , Cruz-Hervert Pablo , Barbosa-Sánchez Larissa , Texcalac-Sangrador José Luis , Romero-Martínez Martín , García-García Lourdes
Published: December 2019

Objetivo. Estimar y comparar las prevalencias de infec­ciones respiratorias agudas (IRA) y enfermedades diarreicas agudas (EDA) en menores de cinco años, residentes en loca­lidades con menos de 100 000 habitantes, mediante análisis de la Encuesta Nacional de Salud y Nutrición (Ensanut) 2012 y la Ensanut 100k (2018). En la Ensanut 100k se evaluaron los factores asociados con IRA y EDA. Material y métodos. Análisis de ambas encuestas e información meteorológica de la Comisión Nacional del Agua. Resultados. La prevalencia global estimada de IRA fue de 45.1% en 2012 vs. 32.9% en 2018. La disminución fue significativa en hogares de medianas y mayores capacidades económicas (CE). No se observaron cambios significativos para las EDA. En hogares con menores CE, las IRA se asociaron con material del techo y temperatura y las EDA con privación de agua entubada. Conclusiones. Entre 2012 y 2018, la prevalencia de IRA disminuyó en hogares de medianas y mayores CE. Algunas condiciones de vivienda y meteorológicas se asocian con IRA y EDA.
La seguridad alimentaria en los hogares en pobreza de México: una mirada desde el acceso, la disponibilidad y el consumo
Authors: Mundo-Rosas Verónica , Unar-Munguía Mishel , Hernández-F Mauricio , Pérez-Escamilla Rafael , Shamah-Levy Teresa
Published: December 2019

Objetivo. Evaluar cambios en la magnitud de la inseguridad alimentaria (IA) en hogares mexicanos en pobreza, en el periodo entre 2012 y 2018 y analizar la asociación entre IA y acceso, disponibilidad y consumo de alimentos. Material y métodos. Se incluyó información de 4 464 hogares de la Encuesta Nacional de Salud y Nutrición en localidades de México con menos de 100 000 habitantes (Ensanut 100k). La IA se midió con la Escala Latinoamericana y Caribeña de Seguridad Alimentaria. El acceso y la disponibilidad se anali­zaron con gasto en alimentos, mientras que el consumo se analizó con la diversidad de la dieta en mujeres. Se estimó la asociación entre IA y gasto en alimentos y la asociación entre IA y diversidad de la dieta con modelos de regresión logística múltiple. Resultados. La IA moderada y severa se mantuvo en 43% entre 2012 y 2018. Mayor gasto en azúcar, aceite y comida fuera de casa, así como el consumo de carnes y lácteos, se asociaron con menor posibilidad de IA. Conclusión. Es importante integrar distintas dimensiones de la IA para forta­lecer su medición y monitoreo.
The Role of Emulsions in Steam-Assisted-Gravity-Drainage (SAGD) Oil-Production Process: A Review
Authors: Ansari Shadi , Sabbagh Reza , Yusuf Yishak , Nobes David S.
Published: December 2019

Studies that investigate and attempt to model the process of steam-assisted gravity drainage (SAGD) for heavy-oil extraction often adopt the single-phase-flow assumption or relative permeability of the moving phases as a continuous phase in their analyses. Looking at the emulsification process and the likelihood of its prevalence in SAGD, however, indicates that it forms an important part of the entire physics of the process. To explore the validity of this assumption, a review of prior publications that are related to the SAGD process and the modeling approaches used, as well as works that studied the emulsification process at reservoir conditions, is presented. Reservoir conditions are assessed to identify whether the effect of the emulsion is strong enough to encourage using a multiphase instead of a single-phase assumption for the modeling of the process. The effect of operating conditions on the stability of emulsions in the formation is discussed. The review also covers the nature and extent of effects from emulsions on the flow mechanics through pore spaces and other flow passages that result from the well completion and downhole tubing, such as sand/flow-control devices. The primary outcome of this review strengthens the idea that a multiphase-flow scenario needs to be considered when studying all flow-related phenomena in enhanced-oil-recovery processes and, hence, in SAGD. The presence of emulsions significantly affects the bulk properties of the porous media, such as relative permeability, and properties that are related to the flow, such as viscosity, density, and ultimately pressure drop. It is asserted that the flow of emulsions strongly contributed to the transport of fines that might cause plugging of either the pore space or the screen on the sand-control device. The qualitative description of these influences and their extents found from the review of this large area of research is expected to guide activities during the conception stages of research questions and other investigations.
C -reactive protein and albumin ratio for the diagnosis of complicated appendicitis in children
Authors: Feng Wei , Yang Qian-Yu , Zhao Xu-Feng , Li Miao-Miao , Cui Hua-Lei
Published: December 2019

Background: No reliably specific marker for complicated appendicitis has been identified. Serum C-reactive protein (CRP) increases and albumin (ALB) decreases in patients with inflammation and infection. C-reactive protein and albumin ratio (CRP/ALB ratio) has been found associated with neonatal septicemia, inflammatory bowel disease and pancreatitis. However, its value in the diagnosis of complicated appendicitis has not been studied. The aim of this study was to evaluate the value of CRP/ALB ratio for predicting complicated appendicitis in children.Methods: A retrospective study of 232 children with acute appendicitis was conducted with assessment of age, gender, weight, symptom duration, albumin and blood routine indexes. According to intraoperative findings and postoperative pathological results, patients were divided into the simple appendicitis group (127 cases) and complicated appendicitis group (105 cases). SPSS version 17 was used to analyse the data.Results: Of the 232 patients, 118 (50.9%) were male and 114 (49.1%) were female. The age range was 1 to 15 years, the mean age of the patients was 8.30 ± 3.25 years. The CRP/ALB ratio was higher in complicated appendicitis compared with simple appendicitis(p<0.05). Logistic regression analysis showed that mononuclear cell (MC), CRP, procalcitonin (PCT) and CRP/ALB ratio were independent risk factors for complicated appendicitis in children. Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of CRP/ALB ratio was higher than MC, PCT and CRP (0.946 vs 0.619 vs 0.843 vs 0.906). CRP/ALB ratio >1.43 was found to be a significant marker in predicting complicated appendicitis with 91.4 % sensitivity and 90.6 % specificity. Compared with CRP/ALB ratio=<1.43, patients with CRP/ALB ratio >1.43 had a 102.22 times higher chance of complicated appendicitis (95% CI:41.322 - 252.874).Conclusion: The CRP/ALB ratio is a novel and promising indicator to predict complicated appendicitis in children before operation，which is easy-to-measure and repeatable. Therefore, CRP/ALB ratio can provide a reference for the choice of surgical treatment for acute appendicitis in children.
Ustekinumab therapy and serum IL-12/IL-23p40 levels for biologic naïve pediatric-onset Crohn disease
Authors: Shiraishi Akira , Ishimura Masataka , Eguchi Katsuhide , Sonoda Motoshi , Tanaka Tamami , Torisu Takehiro , Ohga Shouichi
Published: December 2019

Background: The treatment effect of ustekinumab for Crohn disease (CD) that is refractory to tumor necrosis factor (TNF)-α blockers has been approved in adults, but the indication for pediatric cases remains elusive. The present study aimed to assess the applicability of ustekinumab therapy for biologic naïve pediatric patients.Methods: Four patients who developed CD until 15 years of age and then came to receive ustekinumab as the first-line biologic therapy were enrolled. Clinical and laboratory findings, treatment history, outcomes and adverse events of the biologics were retrospectively studied by using the medical records and interviews to attending doctors. To evaluate the inflammatory profiles at the time of starting ustekinumab, serum concentrations of interleukin (IL)-12/IL-23p40, TNF-α, IL-1β, IL-6, IL-8 and IL-10 were measured by the enzyme-linked immunosorbent or immunobead assays. Results: All patients underwent ustekinumab therapy because of the refractory or relapsing disease on conventional therapy and the individual reasons including optic neuritis. Three out of four patients obtained complete remission followed by successful maintenance, although one failed. No adverse events occurred at all. Pretreatment IL-12/IL-23p40 levels of all three responders, but not one non-responder or healthy controls, exceeded 80 pg/ml. On the other hand, the other cytokine levels of all patients were indifferently negligible. Conclusions: Ustekinumab was effectively used as one of the first-line biologics for the treatment of pediatric-onset CD. The limited indication to anti-TNF therapies or the elevated levels of serum IL-12/IL-23p40 may be a preferable choice of the treatment in childhood.
Compressive Stress Enhances Invasive Phenotype of Breast Cancer Cells via Piezo1 Activation
Authors: Luo Mingzhi , Ho Kenneth KY , Tong Zhaowen , Deng Linhong , Liu Allen
Published: December 2019

Uncontrolled growth in solid tumor generates compressive stress that drives cancer cells into invasive phenotypes, but little is known about how such stress affects the invasion and matrix degradation of cancer cells and the underlying mechanisms. Here we show that compressive stress enhanced invasion and matrix degradation of breast cancer cells. We further identified Piezo1 as the putative mechanosensitive cellular component that transmits compressive stress to induce calcium influx, which in turn activate Src/ERK signaling. Interestingly, we observed actin protrusions with matrix degradation ability on the apical side of the cells. Furthermore, we demonstrate that Piezo1 channels were partially localized in caveolae, and reduction of caveolin-1 expression or disruption of caveolae with methyl-β-cyclodextrin led to not only reduced Piezo1 expression but also attenuation of the invasive phenotypes promoted by compressive stress. Taken together, our data indicate that mechanical compressive stress activates Piezo1 channels to mediate enhanced cancer cell invasion and matrix degradation that may be a critical mechanotransduction pathway during, and potentially a novel therapeutic target for, breast cancer metastasis.
Association between the urban environment and chronic disease to identify communities at risk
Authors: Tan Ken Wei , Yang Qianyu , Lean Yin Ai , Koo Joel Ruihan , Cook Alex R , Dickens Borame L
Published: December 2019

Background: With increasing urbanisation rates, assessments must be made on the impact of the built environment on the health of populations. As the bulk of healthcare expenditure in developed countries is borne by the elderly through chronic disease management and treatment costs, intervening using the built environment can have lasting population-wide effects. Methods: Using two cohort studies for training and validation, we quantified each individual’s local context based on their residential address and derived geographical exposures adapted from the International Physical Activity and the Environment Network guidelines. Bayesian inference was used to develop a regression model that examines the impacts of the geographical exposures and predicts mean body mass index and prevalence of type 2 diabetes mellitus, acute myocardial infarction and stroke by communities. Results: The distance to the nearest retail outlet was found to be negatively associated with body mass index. Our prediction model shows good accuracy (AUC > 0.75) for predicting type 2 diabetes mellitus, acute myocardial infarction and stroke. National-level maps were generated that predict the health of communities by mean body mass index and overall chronic disease risk. Conclusions: The predictive model has the ability to predict on a macro scale the overall health of a community. Understanding the geospatial distribution of chronic disease risk allows for evidence-based policymaking with urban–specific interventions that improve overall population health.
The Hippo effector TAZ cooperates with oncogenic β-catenin in experimental and human hepatoblastoma development
Authors: Tao Junyan , Zhang Shu , Zhang Jie , Evert Katja , Li Xiaolei , Liu Pin , Kiss Andras , Schaff Zsuzsa , Serra Monica , Evert Matthias , Chen Nianyong , Xu Feng , Chen Xin , Calvisi Diego , Cigliano Antonio
Published: December 2019

Backgrounds: Hepatoblastoma (HB) is the most common pediatric liver tumor. Though Wnt/β-catenin and Hippo cascades are implicated in HB development, there is no study on the crosstalk of β-catenin and Hippo downstream effector TAZ in HB. Methods: The expression of TAZ and of β-catenin in human HB specimens was assessed by immunohistochemistry (IHC). The functional interplay between TAZ and β-catenin was tested through delivering either an activated form of TAZ (TAZS89A) alone or co-delivering TAZS89A and an activated form of β-catenin (∆N90-β-catenin) to mouse liver using sleeping beauty transposase via hydrodynamic tail vein injection (SBT-HTVI). In addition, the role of transcriptional enhanced associate domain (TEAD) factors, canonical Notch cascade, Yap, and the tumor modifier heat shock transcription factor 1 (HSF1) along TAZ/β-catenin-driven HB development was studied in vivo and vitro. Results: Activation of TAZ often co-occurred with that of β-catenin in clinical specimens. While overexpression of TAZS89A alone was unable to promote liver tumorigenesis, the concomitant overexpression of TAZ and ∆N90-β-catenin induced the development of HB lesions exhibiting both epithelial and mesenchymal features. Mechanistically, HB development driven by TAZ/β-catenin required TAZ interaction with TEAD factors. Furthermore, TAZ/β-catenin overexpression induced HB development in conditional Yes-associated protein knockout (Yap KO) mice, indicating that Yap activation is dispensable in this model. Activation of the Notch signaling was observed in TAZ/β-catenin mouse lesions, consistent with that reported in human HBs. Blocking of the canonical Notch cascade using the dominant negative form of RBP-J (dnRBP-J) did not inhibit TAZ/β-catenin dependent HB formation in mice, although suppressed the mesenchymal differentiation. Similarly, upregulation of HSF1 was detected in TAZ/β-catenin lesions, but its inactivation did not affect HB development. In human HB cell lines, silencing of TAZ resulted in decreased cell growth, which was reduced more substantially when TAZ knockdown was associated with suppression of either β-catenin or YAP gene. Conclusions: Overall, our study identifies TAZ as a critical oncogene in HB development and progression. Yap, Notch, and HSF1 are dispensable for TAZ/β-catenin induced HB development in mice.
Laboratory parameters in prognostic sickle cell disease cohort studies in children: a systematic review and lessons for an appropriate strategy for analysis
Authors: Sommet Julie , Roux Enora Le , Koehl Berengere , Haouari Zinedine , Mohamed Damir , Baruchel Andre , Benkerrou Malika , Alberti Corinne
Published: December 2019

BACKGROUND: There is a variability of the results in the published prognostic sickle cell disease (SCD) studies. The aim of this article is to assess and demonstrate how the methods used for analysis of laboratory parameters impact the prognostic study results in children with sickle cell disease. METHODS: Firstly, a systematic review of published studies was conducted to identify the methods used in statistical analyses on laboratory parameters. Secondly, four different identified analysis were successively applied on laboratory data collected prospectively in our cohort of newborns with SCD in order to evaluate the association between laboratory parameters and cerebral vasculopathy, depending on the analysis strategy. RESULTS: Thirty-one studies were included in the systematic review in which hemoglobin and reticulocyte counts were the most frequently collected parameters. Through this review, we noted four different statistical strategies. In almost one half of the cohort studies, laboratory parameter was collected only one time per patient. When several values were available, only one statistical analysis considered the time variation. When we applied these four different statistical strategies to our cohort of SCD children, we highlighted that the conclusion on prognostic value of parameters (either as protective or as risk factor) depends on the analysis strategies applied. CONCLUSION: The laboratory parameter prognostic value depends on the analysis strategy chosen for its analysis. It raises fundamental questions about methodological approaches that concern clinician researchers. Identifying prognostic factors is currently essential for better understanding of SCD. Taking into account longitudinal data and standardization of analyses in prognostic cohort studies should allow drawing valuable and reproducible conclusions.
Depth-related variability in viral communities in highly stratified sulphidic mine tailings
Authors: Gao Shao-Ming , Schippers Axel , Chen Nan , Yuan Yang , Zhang Miao-Miao , Li Qi , Liao Bin , Shu Wen-Sheng , Huang Li-Nan
Published: December 2019

Background: Recent studies have significantly expanded our knowledge of viral diversity and functions in the environment. Exploring the ecological relationships between viruses, hosts and the environment is a crucial first step towards a deeper understanding of the complex and dynamic interplays among them.Results: Here, we obtained extensive 16S rRNA gene amplicon, metagenomics sequencing and geochemical datasets from different depths of two highly stratified sulphidic mine tailings cores with steep geochemical gradients especially pH, and explored how variations in viral community composition and functions were coupled to the co-existing prokaryotic assemblages and the varying environmental conditions. Our data showed that many viruses in the mine tailings represented novel genera, based on gene-sharing networks. Siphoviridae and Myoviridae dominated the classified viruses in the surface tailings and deeper layers, respectively. Both viral richness and normalized coverage increased with depth in the tailings cores and were significantly correlated with geochemical properties, for example, pH. Viral richness was also coupled to prokaryotic richness (Pearson’s r = 0.75, P < 0.01). The enrichment of prophages in the surface mine tailings revealed a preference of lysogenic viral lifestyle in more acidic conditions. Community-wide comparative analyses clearly showed that viruses in the surface tailings acquired genes related to low pH adaptation from archaea while viruses in the deeper layers contained genes mainly annotated as conventional viral functions. Notably, abundant auxiliary sulfate reduction genes were identified from the deeper tailings layers and they were widespread in viruses predicted to infect diverse bacterial phyla.Conclusions: Overall, our results revealed a depth-related distribution of viral populations in the extreme and heterogeneous tailings system. The viruses may interact with diverse hosts and dynamic environmental conditions and likely play a role in the functioning of microbial community and modulate sulfur cycles in situ.
Response to immunomodulatory drug-based regimens in heavily pretreated patients with recurrent/refractory adult Langerhans cell histiocytosis
Authors: Cao Xin-xin , Zhao Ai-lin , Gao Xue-min , Miao Hui-lei , Han Hong-xiao , Niu Na , Li Jian , Zhou Dao-bin , Duan Minghui
Published: December 2019

Purpose: Langerhans cell histiocytosis (LCH) is a clonal histiocytic neoplasm and, because of its rarity in adults, there is no standard treatment for adult LCH. Immunomodulatory drugs (IMiDs) have been used to treat patients with low risk recurrent/refractory LCH but their effectiveness in adult LCH patients is unclear.Methods: We retrospectively evaluated the response rate to IMiDs-based regimens in ten heavily pretreated recurrent/refractory adult LCH patients at Peking Union Medical College Hospital.Results: A total of 10 patients (four males and six females) were included in this study. Median age at diagnosis was 33 years (range, 28–54 years). All patients had multisystem involvement and the median number of organs involved was 5 (range, 5–7). Seven patients had high risk organs involved, including seven patients with liver involvement and one with spleen involvement. All 10 patients had received at least one chemotherapy before the IMiDs-based regimen. The median number of previous lines of chemotherapy was 2 (range, 1–4). Eight patients received thalidomide, dexamethasone and cyclophosphamide, and two patients received lenalidomide and dexamethasone. The median time that patients received thalidomide treatment was 15 months and the duration of the two patients on lenalidomide regimen was 3 months and 12 months separately. Treatment responses in eight recurrent LCH patients included non-active disease in one patient and regressive disease in seven patients. The two refractory patients who had progression during the last treatment had stable disease after IMiDs therapy. During a median 15-months follow-up period, no disease reactivation or death was observed.Conclusions: IMiDs combined with dexamethasone and cyclophosphamide, may be a salvage therapy for recurrent/refractory adult LCH patients.
Conjunctive Relation in English Advertisement on Child and Teen Magazines
Authors: Arifah Nur , Djatmika Djatmika , Santosa Riyadi
Published: December 2019

There are many previous types of research about semiotics, language style and image in analyzing advertisements. This study analyzes advertisements by conjunctive relations. This is aimed at observing how the conjunctive relation analyzing the advertisement and constructing the meaning to target readers. This study describes the use of conjunctive relation that results from different stages in the advertisement. The data used advertisements published from August – September 2018 in Junior and Teen Magazine. The method of this study is descriptive qualitative. This study used purposive based sampling based on the objectives of the study. In analyzing data, researchers use Systemic Functional Linguistics approach. This step of analysis uses a domain, taxonomy, componential and cultural theme analysis. The study finds out that the advertisement is structured by exposition genre and the message is delivered well to specific target readers; children or teenagers. Besides,conjunctive relation’s analysis finds the invitation meaning explicitly. In conclusion, the language and meaning are easy to understand both the target readers.
Influence of pH value on sulfonamide ozonation using caffeine as a contamination indicator
Authors: Gireli Glenda Araujo S. , Maniero Milena Guedes , Guimarães José Roberto
Published: December 2019

Ozonation was effective in degrading six sulfonamides: sulfaquinoxaline, sulfamethazine, sulfamethoxazole, sulfathiazole, sulfadimethoxine, and sulfadiazine (C0 = 100 μg L−1). The degradation experiments were based on two variables: pH (3.0, 7.0 and 11.0) and aqueous matrix (ultrapure water, tap water, and surface water). In all matrices studied and pH 11.0, more than 99% of the drugs were degraded with the highest applied ozone dose (65 mg L−1), when compared with other pH values. Also, comparing the three aqueous matrices, the ultrapure water was the one that required the lowest ozone dosage (6.4 mg L−1) to reach the same degradation efficiency of the sulfonamides. Caffeine is known as an environment contamination indicator. Therefore, this does not intend to totally remove this compound, but to verify its degradation level compared with the sulfonamides.
Reassessment of Two Male Portraits in Bursa Museum
Authors: Arlı Yaşar
Published: December 2019

The
most important point in the field of international portrait research is the
question of whether a portrait is official or private. This question also
provides us to answers the questions that to which emperor or empress the
portrait discussed belonged or from which emperor or empress the portrait was
done by inspiring. this important issue is an important factor guiding us for the
identification and dating of the piece. In my paper based on international
portrait research criteria, male heads which were obtained from Bursa and its
surrounding and recently published by R. Ozgan in 2013 have been reinterpreted
and a new suggestion has been tried to be brought by giving justified reasons
for both pieces.
In Silico Studies for Bacterystic Evaluation against Staphylococcus aureus of 2-Naphthoic Acid Analogues
Authors: Monteiro Alex France Messias , Scotti Marcus Tullius , Speck-Planche Alejandro , Barros Renata Priscila Costa , Scotti Luciana
Published: December 2019

Background:

Staphylococcus aureus is a gram-positive spherical bacterium commonly present in
nasal fossae and in the skin of healthy people; however, in high quantities, it can lead to complications that
compromise health. The pathologies involved include simple infections, such as folliculitis, acne, and delay in
the process of wound healing, as well as serious infections in the CNS, meninges, lung, heart, and other areas.

Aim:

This research aims to propose a series of molecules derived from 2-naphthoic acid as a bioactive in the
fight against S. aureus bacteria through in silico studies using molecular modeling tools.

Methods:

A virtual screening of analogues was done in consideration of the results that showed activity according
to the prediction model performed in the KNIME Analytics Platform 3.6, violations of the Lipinski
rule, absorption rate, cytotoxicity risks, energy of binder-receptor interaction through molecular docking, and
the stability of the best profile ligands in the active site of the proteins used (PDB ID 4DXD and 4WVG).

Results:

Seven of the 48 analogues analyzed showed promising results for bactericidal action against S.
aureus.

Conclusion:

It is possible to conclude that ten of the 48 compounds derived from 2-naphthoic acid presented
activity based on the prediction model generated, of which seven presented no toxicity and up to one violation
to the Lipinski rule.
Medicinal Plants and Gyneco-obstetric Disorders among Women in the South East of Morocco
Authors: Eddouks Mohamed , Hebi Morad , Ajebli Mohammed
Published: December 2019

Background:

Phytotherapy is used in developing countries to treat several gynecoobstetric disorders.

Objective:

This study aimed to collect information on herbal remedies traditionally used for the treatment of gyneco-obstetric disorders in the southeast region of Morocco (Tafilalet).

Methods:

Field work was undertaken as an ethnopharmacological survey involving 980 women, 60 herbalists and 20 midwives in 6 different areas of the Tafilalet region. Data was compiled using a semi-structured questionnaire via face-to-face interviews. Three quantitative ethnopharmacological indices (the use value (UV), informant consensus factor (ICF) and fidelity levels (Fl)) were calculated.

Results:

A total of 115 species of plants, belonging to 47 families were identified in this study. The most important species according to their use value were Rosmarinus officinalis (0.40), Lavandula angustifolia (0.35), Origanum vulgare (0.22), Cinnamomum cassia (0.18) and Phoenix dactylifera (0.15). Among the obstetric disorders, the highest ICF values were recorded for menstruation (0.95), female infertility (0.9), and maintenance of pregnancy as well as well-being of fetus (0.87). The analysis showed that the highest Fl value for menstruation was found for Origanum vulgare. (94.07 %) followed by Rosmarinus officinalis (87.29%). For female fertility, the highest Fl value was found in Phoenix dactylifera (77.50%) followed by Lepidium sativum (77.17%).

Conclusion:

This explorative survey emphasizes the need to preserve and document the traditional healing practices for managing gyneco-obstetric disorders and the valorization of this potential could be important for the improvement of women reproductive health.
Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α-glucosidase; Synthesis, Molecular Docking, and Kinetic Study
Authors: Tafesse Tadesse Bekele , Moghadam Ebrahim Saeedian , Bule Mohammed Hussen , Faramarzi Mohammad Ali , Abdollahi Mohammad , Amini Mohsen
Published: December 2019

Background:

The delaying of absorption of glucose is one of the principal therapeutic
approaches of type 2 diabetes. α-glucosidase inhibitors compete with the α-glucosidase enzyme activity,
which helps to reduce the conversion of carbohydrates into glucose and thereby control the
postprandial hyperglycemia incidence.

Objective:

The aim of this study was to synthesize a series of novel 1,5-diphenyl pyrrole derivatives
and evaluate their in vitro α-glucosidase inhibitory activities.

Methods:

Compounds were synthesized through a multistep reaction and were evaluated for α-
glucosidase inhibitory activities. Molecular docking and kinetic studies were carried out to predict
the mode of binding and mechanism of inhibition for the most active compounds, 5g and 5b,
against α-glucosidase.

Results:

Synthesized compounds showed good in vitro α-glucosidase inhibitory activity with IC50
values in the range of (117.5 ± 3.8 to 426.0 ± 10.2 μM) as compared to acarbose, the standard
drug, (750 ± 8.7 μM). Compound 5g (117.5 ± 3.8 μM) ascertained as the most potent inhibitor of
α-glucosidase in a competitive mode. The binding energies of compounds 5g and 5b (119.0 ± 7.5
μM), as observed from the best docking conformations, indicate that they have a lower free binding
energy (-3.26 kcal/mol and -3.0 kcal/mol, respectively) than acarbose (2.47 kcal/mol).

Conclusion:

The results of our study revealed that the synthesized compounds are a potential candidate
for α-glucosidase inhibitors for the management of postprandial hyperglycemia for further
investigation.
Job satisfaction mediating towards effect of emotional intelligence on performance
Authors: Lestari Ida Ayu Putri Widya , Wibawa I Made Artha
Published: December 2019

The study was conducted at BBPOM in Denpasar. The number of samples used was as many as 90 people using the saturated sample selection method. Data collection using a questionnaire that uses a Likert scale. Data analysis techniques were performed using structural equation modeling with a partial least square approach and using the VAF test to test the role of mediation. The results showed that emotional intelligence had a significant positive effect on employee performance at BBPOM in Denpasar with a path coefficient of 0.469. Job satisfaction is known to partially mediate the relationship of emotional intelligence to employee performance at BBPOM in Denpasar. The findings in this study provide the implication that to produce good performance in order to achieve excellent service, it is necessary to have activities in the form of training related to emotional intelligence and job satisfaction that can effectively improve employee skills to have an understanding and sensitivity to emotions of themselves and others, so that employees can deal well with all forms of organizational life dynamics and show maximum performance to achieve excellent service.
Multidimensional diagnosis of competitive anxiety in youth baseball team
Authors: Chang Milan Ochoa , Torres Ana Celia Matarán
Published: December 2019

Santiago de Cuba It is one of the provinces with the best sports results in Cuban history, baseball is one of the leading disciplines in this regard, however, in recent years, such achievements have been affected. Multiple are the answers that technicians, researchers, and specialists have tried to offer these unfortunate events. Youth baseball has not been exempt from this problem and, in this sense, Sports Psychology has played an important role in the study and search for scientific alternatives that contribute to reversing these results. During the last 3 years, high manifestations of competitive anxiety have been observed in baseball players in this category, this fact motivates the present investigation, it aims to rigorously diagnose how this negative emotion has been presented in said population. To complete the objective, the 25 members of the Santiago youth team were selected as a sample, the study is descriptive, being able to record, analyze and describe the general and observable characteristics of anxiety in real moments of training sessions and competitions, it is supported by the qualitative-quantitative methodology using psychological techniques such as observation, interview, CSAI-2, attitude tests for competition and appreciation of time and pulsometer.
Selfie tourism promotion to support innovative tourism in the era of disruption
Authors: Sari Putu Ratna Juwita , Wisudawati Ni Nyoman Sri , Yulianti Ni Made Dhian Rani
Published: December 2019

In the current era of disruption, innovation and creativity are needed in all lines of business, including the Tourism sector. Wanagiri Village is one of the tourist destination areas which is located in Buleleng Regency is currently conducting promotions to attract tourists visiting this place. Having a strategic location and involving the community, the type of tourist attraction developed is a selfie tour by having lakes and mountains as background. Using SWOT analysis, it is expected to be able to find out which type of promotion is most appropriate to attract tourists. This study used a qualitative descriptive method, informants with purposive sampling, and triangulation of data aimed at obtaining data validity.
Implementation of human resource development to improve employee performance
Authors: Yuliantari Putu Devi , Martini Ida Ayu Oka
Published: December 2019

This study aimed to determine how the implementation of human resource development to improve employee performance on Banyualit Spa ‘n Resort. Human resource development is the people or employee preparation to assume higher responsibilities in the organization or company. Performance is the work result/a process measurement or a person’s achievements regarding tasks assigned to them. The research design used in this study was a descriptive study with a qualitative approach. It was conducted at the Banyualit Spa ‘n Resort located in Lovina, Singaraja Bali. The study results indicated that the Banyualit Spa ‘n Resort has developed human resources well. However, it needs to be improved.
UPAYA PENINGKATAN PEMBELAJARAN LOMPAT JAUH GAYA MENGGANTUNG DENGAN METODE BAGIAN PROGRESIF SISWA SMAN 1 CEPER
Authors: Hidayat Mufti , Tomoliyus Tomoliyus
Published: December 2019

Penelitian ini bertujuan untuk meningkatkan pembelajaran teknik lompat jauh gaya menggantung siswa kelas X F SMAN 1 Ceper dengan metode bagian progresif. Jenis penelitian ini adalah penelitian tindakan kelas. Penelitian tindakan adalah kajian sistematik dari upaya perbaikan pelaksanaan praktik pendidikan oleh sekelompok guru dengan melakukan tindakan-tindakan dalam pembelajaran, berdasarkan refleksi mengenai hasil dari tindakan-tindakan tersebut. Penelitian ini dilaksanakan di SMAN 1 Ceper Klaten semester genap tahun pelajaran 2011/2012. Subjek penelitian adalah kelas X F dengan jumlah siswa 23 anak. Penelitian ini dilaksanakan pada bulan Maret-Mei 2012. Hasil analisis penilaian terhadap siswa-siswa kelas X F SMAN 1 Ceper pada cabang atletik lompat jauh gaya menggantung pada semester gasal tahun pelajaran 2011/2012, bahwa mayoritas siswa mengalami kesulitan melakukan tolakan. Hasil penelitian menunjukkan belum terjadi peningkatan hasil belajar siswa rata-rata skor pada siklus I adalah 68,75. Pada siklus II terjadi peningkatan hasil belajar siswa rata-rata skor adalah 80,97.  IMPROVING THE LEARNING OF HANG STYLE LONG JUMP WITH PROGRESSIVE PART METHOD OF STUDENTS AT SMAN 1 CEPERAbstract This research is aimed to improve the implementation of hang style long jump technique with progressive part method of class XF students at SMAN 1 Ceper The type of the research is classroom action research. Classroom action research is a systematic study of improving the educational practice implementation by a group of teachers to perform actions in learning, based on their reflections on the results of the actions. This study was conducted at SMAN 1 Ceper Klaten which was in the even semester of 2011/2012 academic year and the research subject was class XF consisting of 23 students. The research was conducted from March to May 2012. Based on the assessment analysis result of class X students SMAN 1 Ceper’ on athletic hang style long jump in the even semester of 2011/2012 academic year, the majority of the students have difficulty in doing repulsion. The research result shows that there is not yet an increase of the students' learning result, the average score in Cycle I is 68.75. In Cycle II there is an increase of the students' learning result, the average score is 80.97 Keywords: hang style long jump, progressive part method
MODIFIKASI MODEL PEMBELAJARAN SPORT EDUCATION BERBASIS KEJUARAAN UNTUK GURU PENJAS SMP
Authors: Dalton Wilian , Rachman Hari Amirullah
Published: December 2019

Penelitian ini bertujuan untuk modifikasi model pembelajaran sport education berbasis kejuaraan untuk guru penjas SMP, dalam bentuk buku panduan pelaksanaan model pembelajaran berbasis kejuaraan. Penelitian ini merupakan penelitian dan modifikasi. Pengembangan dilakukan mengacu pada model pengembangan Borg & Gall dan Sugiyono dengan beberapa modifikasi menjadi lima tahap. Subjek uji coba dalam penelitian ini adalah siswa SMP 1 Panggang, SMP 1 Mlati dan MTs Banyusoca. Instrumen yang digunakan adalah lembar validasi untuk ahli dan praktisi penjas, lembar observasi, angket untuk penilaian guru dan angket untuk tanggapan siswa. Hasil penelitian menunjukkan bahwa: (1) Prosedur pengembangan melalui lima tahap, yaitu tahap studi pendahuluan, tahap desain produk, Tahap validasi ahli, tahap uji coba dan revisi produk dan tahap produk akhir. (2) Buku terdiri atas tiga bab, yaitu bab 1, pengenalan pembelajaran berbasis kejuaraan; bab 2, tata laksana pembelajaran berbasis kejuaraan; dan bab 3, penutup. (3) Hasil validasi menunjukkan buku panduan yang dikembangkan layak digunakan dengan kategori sangat tinggi. (4). Penilaian guru pendidikan jasmani terhadap kualitas buku panduan dengan rerata sebesar 16 (masuk dalam kategori sangat tinggi). Tanggapan siswa terhadap pelaksanaan pembelajaran sport education rerata sebesar 9,06 (masuk dalam kategori sangat tinggi). (5) Kesimpulannya buku panduan pelaksanaan model pembelajaran sport education layak untuk digunakan sebagai sumber belajar. Kata kunci: modifikasi buku panduan, penjas, sport education model
Compliance and Retention With the Experience Sampling Method Over the Continuum of Severe Mental Disorders: Meta-Analysis and Recommendations
Authors: Vachon Hugo , Viechtbauer Wolfgang , Rintala Aki , Myin-Germeys Inez
Published: December 2019

Background

Despite the growing interest in the experience sampling method (ESM) as a data collection tool for mental health research, the absence of methodological guidelines related to its use has resulted in a large heterogeneity of designs. Concomitantly, the potential effects of the design on the response behavior of the participants remain largely unknown.

Objective

The objective of this meta-analysis was to investigate the associations between various sample and design characteristics and the compliance and retention rates of studies using ESM in mental health research.

Methods

ESM studies investigating major depressive disorder, bipolar disorder, and psychotic disorder were considered for inclusion. Besides the compliance and retention rates, a number of sample and design characteristics of the selected studies were collected to assess their potential relationships with the compliance and retention rates. Multilevel random/mixed effects models were used for the analyses.

Results

Compliance and retention rates were lower for studies with a higher proportion of male participants (P<.001) and individuals with a psychotic disorder (P<.001). Compliance was positively associated with the use of a fixed sampling scheme (P=.02), higher incentives (P=.03), higher time intervals between successive evaluations (P=.02), and fewer evaluations per day (P=.008), while no significant associations were observed with regard to the mean age of the sample, the study duration, or other design characteristics.

Conclusions

The findings demonstrate that ESM studies can be carried out in mental health research, but the quality of the data collection depends upon a number of factors related to the design of ESM studies and the samples under study that need to be considered when designing such protocols.
Engagement With Motivational Interviewing and Cognitive Behavioral Therapy Components of a Web-Based Alcohol Intervention, Elicitation of Change Talk and Sustain Talk, and Impact on Drinking Outcomes: Secondary Data Analysis (Preprint)
Authors: Mujcic Ajla , Linke Stuart , Hamilton Fiona , Phillips Alexandria , Khadjesari Zarnie
Published: December 2019

BACKGROUND

Down Your Drink (DYD) is a widely used unguided web-based alcohol moderation program for the general public based on cognitive behavioral therapy (CBT) and motivational interviewing (MI); it provides users with many opportunities to enter free-text responses.

OBJECTIVE

The aim of this study was to assess participants’ use of key CBT and MI components, the presence of change talk and sustain talk within their responses, and whether these data are associated with drinking outcomes after 3 months.

METHODS

An exploratory secondary data analysis was conducted on data collected in 2008 from the definitive randomized trial of DYD (N=503). Past week alcohol use at baseline and 3-month follow-up were measured with the TOT-AL. Covariates included baseline alcohol use, age, gender, education level, and word count of the responses. Use of MI and CBT components and presence of change talk and sustain talk were coded by two independent coders (Cohen κ range 0.91-1). Linear model regressions on the subsample of active users (n=410) are presented along with a negative binomial regression.

RESULTS

The most commonly used component was the listing of pros and cons of drinking. The number of listed high-risk situations was associated with lower alcohol use at 3-month follow-up (Badj −2.15, 95% CI −3.92 to −0.38, P=.02). Findings on the effects of the percentage of change talk and the number of listed strategies to deal with high-risk situations were inconsistent.

CONCLUSIONS

An unguided web-based alcohol moderation program can elicit change talk and sustain talk. This secondary analysis suggests that the number of listed high-risk situations can predict alcohol use at 3-month follow-up. Other components show inconsistent findings and should be studied further.