bluuebunny/crossref_metadata_2025 huggingface dataset:
Testing the effects of pathogen threat and sexual strategies on political ideology
Authors: Shook Natalie J. , Oosterhoff Benjamin
Published: September 2020

Abstract

Disgust has been consistently associated with greater political conservatism. Two explanations have been proposed for this link. According to a pathogen threat model, disgust serves a pathogen-avoidance function, encouraging more conservative ideology, whereas a sexual strategies model suggests that this link is explained by variability in short-term versus long-term mating goals. In two preregistered studies using a college student and community sample (total N = 1,950), we examined whether experimentally manipulating pathogen threat and mate availability produced differences in political ideology and whether these differences were explained by disgust and sociosexual attitudes. Across both studies, we did not find evidence that manipulating pathogen threat or mate availability resulted in change in political ideology. In Study 1, manipulating mate availability was indirectly associated with greater political conservativism through stronger sociosexual attitudes that favor monogamy. These findings failed to replicate in Study 2. Implications for theory and future research are discussed.
Associations between different types and sources of dietary fibre intake and depressive symptoms in a general population of adults: a cross-sectional study
Authors: Xia Yang , Liu Yashu , Zhang Shunming , Zhang Qing , Liu Li , Meng Ge , Wu Hongmei , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Song Kun , Wu Qijun , Niu Kaijun , Zhao Yuhong
Published: September 2020

This cross-sectional study aimed to examine the associations between dietary fibre (DF) intake and depressive symptoms in a general adult population in Tianjin, China. A total of 24 306 participants (mean age 41 years; range 18–91 years) were enrolled. DF intake was assessed using a validated self-administered FFQ. Depressive symptoms were assessed using the Self-Rating Depression Scale. Associations between DF intake and depressive symptoms were estimated using logistic regression analysis. Socio-demographic, behavioural, health status and dietary factors were adjusted. In men, compared with participants in the lowest quartiles for total, soluble, vegetable and soya DF, OR for depressive symptoms in the highest were 0·83 (95 % CI 0·69, 0·99), 0·74 (95 % CI 0·63, 0·87), 0·79 (95 % CI 0·65, 0·96) and 0·69 (95 % CI 0·60, 0·81), respectively. In women, compared with participants in the lowest quartiles for vegetable and soya DF, the OR for depressive symptoms in the highest were 0·77 (95 % CI 0·64, 0·93) and 0·82 (95 % CI 0·70, 0·95), respectively. No association was found between total or soluble DF intake and depressive symptoms in women. No association was found between insoluble, cereal, fruit or tuber DF intake and depressive symptoms in men and women. Linear associations between DF intake and depressive symptoms were only detected for soya DF (men, β = –0·148, P < 0·0001; women, β = –0·069, P = 0·04). Results suggest that intake of soluble, vegetable and soya DF was inversely associated with depressive symptoms. These results should be confirmed through prospective and interventional studies.
Dissimilar regulation of glucose and lipid metabolism by leptin in two strains of gibel carp (Carassius gibelio)
Authors: Wu Liyun , Li Hongyan , Xu Wenjie , Dong Bo , Jin Junyan , Han Dong , Zhu Xiaoming , Yang Yunxia , Liu Haokun , Xie Shouqi
Published: September 2020

Previous nutritional studies have shown that insulin regulation is different between DT and A strains of gibel carp. As leptin plays a pivotal role in the effects of insulin, we hypothesised that leptin regulation of glucose and lipid metabolism would differ between the two strains. To test our hypothesis, recombinant human leptin was injected into two strains. The results showed that leptin activated the phosphatidylinositol 3-kinase (PI3K)–protein kinase B (AKT), AMP-activated protein kinase–acetyl coenzyme A carboxylase and Janus kinase 2 (JAK2)–signal transducer and activator of transcription (STAT) signalling pathways in both strains. Hypoglycaemia induced by leptin might be due to higher glucose uptake by the liver and muscles together with enhanced glycolytic potential and reduced gluconeogenic potential. Decreased lipogenesis and up-regulated fatty acid oxidation were induced by leptin. In terms of genotype, the PI3K–AKT signalling pathway was more strongly activated by leptin in the muscle tissue of the A strain, as reflected by the heightened phosphorylation of AKT. Furthermore, glycogen content, glycolytic enzyme activity and gluconeogenic capability were higher in the A strain than the DT strain. Strain A had higher levels of fatty acid synthesis and lipolytic capacity in the liver than the DT strain, but the opposite was true in white muscle. Regarding leptin–genotype interactions, the DT strain displayed stronger regulation of glucose metabolism in the liver by leptin as compared with the A strain. Moreover, a more active JAK2–STAT signalling pathway accompanied by enhanced inhibition of fatty acid synthesis by leptin was observed in the DT strain. Overall, the regulation of glucose and lipid metabolism by leptin differed between the two strains, as expected.
40Ar/39Ar age constraints for an early Alpine metamorphism of the Sakar unit, Sakar–Strandzha zone, Bulgaria
Authors: Bonev Nikolay , Spikings Richard , Moritz Robert
Published: September 2020

We investigated the Sakar unit metamorphic rocks of the Sakar–Strandzha zone in Bulgaria, using40Ar/39Ar dating of amphibole from the polymetamorphic basement and white mica in the overlying upper Permian metasedimentary rocks of the Paleokastro Formation. The amphibole and white mica revealed plateau ages of 140.50 ± 1.75 Ma and 126.19 ± 1.29 Ma, respectively, indicating an Early Cretaceous cooling history of the regional amphibolite-facies metamorphism to greenschist-facies conditions. Similar metamorphic grades and cooling histories of the Sakar unit share evidence with the nearby Rhodope Massif for the northern Aegean region-wide early Alpine tectonometamorphic event.
Detrital zircon U–Pb–Hf isotopes for the Permo-Carboniferous sediments in the northern Alxa area, NW China: provenance and tectonic implications for the middle segment of the Central Asian Orogenic Belt
Authors: Chen Yan , Wu Tairan , Zhang Zhicheng
Published: September 2020

The northern Alxa orogenic belt, located in the middle segment of the Central Asian Orogenic Belt, is a junction between the North China Craton, Tarim Craton and Mongolian microcontinents. However, its Permo-Carboniferous tectono-palaeogeographic evolution has not been well established. In this study, new zircon U–Pb–Hf isotopic data for the Permo-Carboniferous clastic rocks were used to address the above issue. Based on our dating work and fossil assemblages, we confirmed that the Amushan, Maihanhada, Aqide and Haersuhai formations were formed in the late Carboniferous to early Permian, early to middle Permian, middle Permian and late Permian periods, respectively. The Amushan Formation sandstone in the Zhusileng area contains abundant Palaeozoic zircons (with age peaks at 440 Ma, 475 Ma and 539 Ma) and some Precambrian zircons. These zircon ages and the southeast transgressive direction suggest the provenance to be the local Zhusileng–Hangwula block and the nearby Yagan continental margin. The zircon age pattern with a high proportion of detrital zircons much older than the depositional time and no detrital zircons close to the depositional time suggest an extensional basin depositional setting. The clastic rocks of the Maihanhada, Aqide and Haersuhai formations inherited the source for the Amushan Formation, with a greatly increased input of Permo-Carboniferous volcanic rocks with post-collision or intraplate chemical affinity. Accordingly, a Permo-Carboniferous extensional stage was suggested. Finally, a tectono-palaeogeographic model was reconstructed for the northern Alxa orogenic belt, evolving from a late Carboniferous transgression with crustal extension to early to middle Permian rapid basin filling and a late Permian marine regression.
Neisseria meningitidis carriage and risk factors among teenagers in Suizhou city in China
Authors: He Fei , Yang Hong mei , Li Guo ming , Zhu Bing qing , Zhang Yating , Jiang Hong lin , Yuan Min , Jiang Yongzhong , Lv Jing
Published: September 2020

Teenagers are important carriers of Neisseria meningitidis, which is a leading cause of invasive meningococcal disease. In China, the carriage rate and risk factors among teenagers are unclear. The present study presents a retrospective analysis of epidemiological data for N. meningitidis carriage from 2013 to 2017 in Suizhou city, China. The carriage rates were 3.26%, 2.22%, 3.33%, 3.53% and 9.88% for 2013, 2014, 2015, 2016 and 2017, respectively. From 2014 to 2017, the carriage rate in the 15- to 19-year-old age group (teenagers) was the highest and significantly higher than that in remain age groups. Subsequently, a larger scale survey (December 2017) for carriage rate and relative risk factors (population density, time spent in the classroom, gender and antibiotics use) were investigated on the teenagers (15- to 19-year-old age) at the same school. The carriage rate was still high at 33.48% (223/663) and varied greatly from 6.56% to 52.94% in a different class. Population density of the classroom was found to be a significant risk factor for carriage, and 1.4 persons/m2 is recommended as the maximum classroom density. Further, higher male gender ratio and more time spent in the classroom were also significantly associated with higher carriage. Finally, antibiotic use was associated with a significantly lower carriage rate. All the results imply that attention should be paid to the teenagers and various measures can be taken to reduce the N. meningitidis carriage, to prevent and control the outbreak of IMD.
Photoreceptor responses to light in the pathogenesis of diabetic retinopathy
Authors: Majidi Shahriyar P. , Rajagopal Rithwick
Published: September 2020

Vision loss, among the most feared complications of diabetes, is primarily caused by diabetic retinopathy, a disease that manifests in well-recognized, characteristic microvascular lesions. The reasons for retinal susceptibility to damage in diabetes are unclear, especially considering that microvascular networks are found in all tissues. However, the unique metabolic demands of retinal neurons could account for their vulnerability in diabetes. Photoreceptors are the first neurons in the visual circuit and are also the most energy-demanding cells of the retina. Here, we review experimental and clinical evidence linking photoreceptors to the development of diabetic retinopathy. We then describe the influence of retinal illumination on photoreceptor metabolism, effects of light modulation on the severity of diabetic retinopathy, and recent clinical trials testing the treatment of diabetic retinopathy with interventions that impact photoreceptor metabolism. Finally, we introduce several possible mechanisms that could link photoreceptor responses to light and the development of retinal vascular disease in diabetes. Collectively, these concepts form the basis for a growing body of investigative efforts aimed at developing novel pharmacologic and nonpharmacologic tools that target photoreceptor physiology to treat a very common cause of blindness across the world.
Longitudinal associations between mother–child conflict and child internalizing problems in mid-childhood
Authors: Lougheed Jessica P. , Duncan Robert J. , Keskin Gizem , Marceau Kristine
Published: September 2020

Several aspects of mother–child relationships are associated with children's internalizing problems. We examined longitudinal associations between mother–child conflict and children's internalizing problems in middle childhood. Specifically, we examined whether conflict and children's internalizing problems predict each other longitudinally in a sample of children from 3rd through 6th grade (N = 1,364) and their mothers using a cross-lagged panel model with random intercepts. In line with expectations, we found stable between-family differences in both mother–child conflict and children's internalizing problems. Contrary to expectations, we did not find that mother–child conflict and children's internalizing problems showed significant cross-lagged associations. However, mother–child conflict and children's internalizing problems had correlated errors at each wave, indicating that these two constructs covary with each other concurrently at multiple times across development, independent of stable between-family associations (i.e., as one increases, so does the other, and vice versa). The results of this study point to the importance of using statistical approaches that can disentangle between-family differences from within-family processes. In future studies, shorter time scales (e.g., weeks or months) may better capture dynamic associations between parent–child conflict and internalizing problems.
Rescue Intubation in the Emergency Department After Prehospital Ketamine Administration for Agitation
Authors: Parks Daniel J. , Alter Scott M. , Shih Richard D. , Solano Joshua J. , Hughes Patrick G. , Clayton Lisa M.
Published: September 2020

Objective:

Prehospital intramuscular (IM) ketamine is increasingly used for chemical restraint of agitated patients. However, few studies have assessed emergency department (ED) follow-up of patients receiving prehospital ketamine for this indication, with previous reports suggesting a high rate of post-administration intubation. This study examines the rate of and reasons for intubation and other airway interventions in agitated patients who received ketamine by Emergency Medical Services (EMS).

Methods:

This retrospective cohort study included patients who received prehospital ketamine for agitation and were transported to two community hospital EDs. Charts were reviewed for demographics, ketamine dose, and airway intervention by EMS or in the ED. Characteristics of patients who were intubated versus those who did not receive airway intervention were analyzed.

Results:

Over 28 months, 86 patients received ketamine for agitation. Fourteen (16.3%) underwent endotracheal intubation. Patients with a higher temperature and a lower Glasgow Coma Score (GCS) were more likely to require intubation. There was no age or dose-dependent association on intubation rate. Intubated patients averaged 39 years old versus 44 for patients not intubated (negative five-year difference; 95% CI, -16 to 6). The mean ketamine dose was 339.3mg in patients intubated versus 350.7mg in patients not (-11.4mg difference; 95% CI, -72.4 to 49.6). The mean weight-based ketamine dose was 4.44mg/kg in patients intubated versus 4.96mg/kg in patients not (-0.53mg/kg difference; 95% CI, -1.49 to 0.43).

Conclusions:

The observed rate of intubation in patients receiving prehospital ketamine for agitation was 16.3%. Study data did not reveal an age or dose-dependent rate of intubation. Further research should be conducted to compare the airway intervention rate of agitated patients receiving ketamine versus other sedatives in a controlled fashion.
Knowledge and acceptance of interventions aimed at reducing sugar intake in Portugal
Authors: Prada Marília , Rodrigues David L , Godinho Cristina A , Lopes Diniz , Garrido Margarida V
Published: September 2020

Objective:

Governments worldwide have been implementing interventions aimed at improving citizens’ dietary habits. Examining how individuals perceive these interventions is relevant for promoting future policies in this area, as well as informing the way they are designed and implemented. In the current study, we focused on interventions aimed at reducing sugar intake in Portugal, given the current high sugar consumption patterns in the population.

Design:

Online survey to assess which interventions are the most salient and receive greater public support.

Setting:

Portugal.

Participants:

1010 (76·7 % female, MAge 36·33, sd 13·22).

Results:

Data from a free-recall task showed that only about one-third of participants reported knowing about these interventions, namely those related to taxation, weight restrictions in individual sugar packets and limited availability of products with high sugar content. We also found evidence of high support for the eight interventions presented (except for replacing sugar by artificial sweeteners), positive attitudes towards the need of reducing sugar intake in the Portuguese population and high agreement with the importance of reducing sugar intake across all age groups, particularly among children. Participants also indicated paying attention to the amount of sugar in their diets and a low self-reported frequency of consumption of high sugary foods and beverages. A hierarchical regression analysis suggested that these variables were significantly associated with the overall acceptance of interventions, independently of social-demographic variables (i.e., age, education and sex).

Conclusion:

By examining how people perceive and accept different interventions targeting the reduction of sugar intake, the current work aims to support policymaking in this domain.
Do Elites Discriminate against Female Political Aspirants? Evidence from a Field Experiment
Authors: Dhima Kostanca
Published: September 2020

Do elites exhibit gender bias when responding to political aspirants? Drawing on theories of gender bias, group attachment, and partisan identity, I conduct the first audit experiment outside the United States to examine the presence of gender bias in the earliest phases of the political recruitment process. Based on responses from 1,774 Canadian legislators, I find evidence of an overall gender bias in favor of female political aspirants. Specifically, legislators are more responsive to female political aspirants and more likely to provide them with helpful advice when they ask how to get involved in politics. This pro-women bias, which exists at all levels of government, is stronger among female legislators and those associated with left-leaning parties. These results suggest that political elites in Canada are open to increasing female political representation and thus should serve as welcome encouragement for women to pursue their political ambitions.
Herbicidal control of deathcamas (Zigadenus paniculatus)
Authors: Stonecipher Clinton A. , Ransom Corey , Thacker Eric , Welch Kevin , Gardner Dale R. , Palmer Matt
Published: September 2020

Foothill deathcamas is a bulbous, perennial, native forb found throughout the western United States. Deathcamas begins growth early in the spring. The lack of alternative forages at this time can result in livestock becoming poisoned from the consumption of deathcamas. Research on herbicides for deathcamas control is limited to work from the 1950s and 1960s that identified 2,4-D as a control agent. The objective of this study was to evaluate alternative herbicide options for deathcamas control that include 2,4-D, 2,4-D + triclopyr, quinclorac, aminopyralid, imazapic, and chlorsulfuron. We also investigated the impact of plant growth stage on deathcamas control by making herbicide applications at two growth stages. One set of plots was treated with herbicides when deathcamas was in the early vegetative stage and the second set was treated at flowering. There is some evidence that stress might affect alkaloid content; therefore, we monitored alkaloid content of treated and nontreated deathcamas. Plots were established at Mt. Sterling, UT, and Mt. Pleasant, UT. Deathcamas density was reduced in 2,4-D, 2,4-D + triclopyr, and imazapic treatments 1 and 2 yr after herbicide application (P < 0.0001). Compared with the pretreatment densities, deathcamas densities(± standard error of the mean) 2 yr after herbicide application were reduced 96% ± 1.4%, 100% ± 0%, and 98% ± 0.9% for 2,4-D, 2,4-D + triclopyr, and imazapic, respectively, at the Mt. Sterling site. At the Mt. Pleasant site, deathcamas density was reduced by 84% ± 2.8% with 2,4-D alone, whereas 2,4-D + triclopyr and imazapic provided similar density reductions as observed at the Mt. Sterling site. Steroidal alkaloid concentrations did not change in herbicide-treated deathcamas at either stage of plant growth. These data indicate that 2,4-D, 2,4-D + triclopyr, and imazapic can effectively control deathcamas in the vegetative and flowering growth stages.
Effects of fall-planted cereal cover-crop termination time on glyphosate-resistant horseweed (Conyza canadensis) suppression
Authors: Schramski John A. , Sprague Christy L. , Renner Karen A.
Published: September 2020

Integrated strategies for management of glyphosate-resistant (GR) horseweed are needed to reduce reliance on herbicides. Planting a cover crop after corn or soybean harvest in the Upper Midwest may reduce horseweed establishment and growth. Experiments were conducted in Michigan to determine if cereal rye and winter wheat, seeded at 67 or 135 kg ha−1, and terminated with glyphosate at 1.27 kg ae ha−11 wk before planting (early termination) or 1 wk after soybean planting (planting green) would suppress establishment and growth of GR horseweed. Cover-crop biomass was 212% to 272% higher when termination was delayed by planting green compared with early termination. At the time of termination, cover crops reduced GR horseweed biomass 41% to 89% compared with no cover. Planting green increased the C:N ratio of cover-crop residue, which improved residue persistence and GR horseweed suppression at the time of POST herbicide application, approximately 5 wk after planting. Planting green reduced GR horseweed biomass 46% to 93% compared with no cover at the time of POST herbicide application; early termination provided less consistent suppression. Cover crops alone did not suppress GR horseweed through soybean harvest. Soybean yield was 30% to 108% greater when planting green compared with early termination at 2 site-years. Cereal rye and winter wheat, seeded at 67 or 135 kg ha−1, provided early-season GR horseweed suppression. Results from this research indicate that the practice of planting green may improve GR horseweed suppression through the time of POST herbicide application.
A review of soft wearable robots that provide active assistance: Trends, common actuation methods, fabrication, and applications
Authors: Thalman Carly , Artemiadis Panagiotis
Published: September 2020

This review meta-analysis combines and compares the findings of previously published works in the field of soft wearable robots (SWRs) that provide active methods of actuation for assistive and augmentative purposes. A thorough investigation of major contributions in the field of an SWR is made to analyze trends in the field focused on fluidic and cable-driven systems, prevalent and successful approaches, and identify the future direction of SWRs and active actuation strategies. Types of soft actuators used in wearables are outlined, as well as general practices for fabrication methods of soft actuators and considerations for human–robot interface designs of garment-like exosuits. An overview of well-known and emerging upper body (UB)- and lower body (LB)-assistive technologies is categorized by the specific joints and degree of freedom (DoF) assisted and which actuator methodology is provided. Different use cases for SWRs are addressed, as well as implementation strategies and design applications.
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm
Authors: Jeong Se-Jin , Cho Min Ji , Ko Na Young , Kim Sinai , Jung In-Hyuk , Min Jeong-Ki , Lee Sang Hak , Park Jong-Gil , Oh Goo Taeg
Published: September 2020

Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease characterized by structural deterioration of the aorta caused by inflammation and oxidative stress, leading to aortic dilatation and rupture. Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, has been reported as a potential negative regulator of inflammatory vascular diseases, and it has been identified as a protein that is increased in patients with ruptured AAA compared to patients with nonruptured AAA. In this study, we demonstrated that PRDX2 was a pivotal factor involved in the inhibition of AAA progression. PRDX2 levels were increased in AAA compared with those in normal aortas in both humans and mice. Ultrasound imaging revealed that the loss of PRDX2 accelerated the development of AAA in the early stages and increased AAA incidence in mice infused with angiotensin II (Ang II). Prdx2−/− mice infused with Ang II exhibited increased aortic dilatation and maximal aortic diameter without a change in blood pressure. Structural deterioration of the aortas from Prdx2−/− mice infused with Ang II was associated with increases in the degradation of elastin, oxidative stress, and intramural thrombi caused by microhemorrhages, immature neovessels, and the activation of matrix metalloproteinases compared to that observed in controls. Moreover, an increase in inflammatory responses, including the production of cell adhesion molecules and the accumulation of inflammatory cells and proinflammatory cytokines due to PRDX2 deficiency, accelerated Ang II-induced AAA progression. Our data confirm that PRDX2 plays a role as a negative regulator of the pathological process of AAA and suggest that increasing PRDX2 activity may be a novel strategy for the prevention and treatment of AAA.
The perceptions of preclinical and clinical dental students to altered smile aesthetics
Authors: Aljefri Maha , Williams Julie
Published: September 2020

Introduction

This prospective cohort study was designed to identify which components of a smile make it more or less aesthetically acceptable to dental students.

Aim

To investigate whether students at different stages of their undergraduate dental education held similar views on smile aesthetics. Additionally, to see whether students from the same ethnicity were more likely to have similar perceptions of smile aesthetics than students from different backgrounds.

Methodology

Dental students in either Year 1 (preclinical) or Year 5 (clinical) of their studies at the University of Bristol were asked to complete a questionnaire. Students were asked to rank 12 photographic images in order from most aesthetically pleasing (1) to least pleasing (12). The 12 images included one ‘ideal’ smile and 11 digitally altered images of the same “ideal” smile.

Results

A total of 123 questionnaires were completed. Clinical students were more likely to rank the ‘ideal smile’ as more aesthetically pleasing and identify it as the “best” smile from the set of images. Preclinical students considered retroclined incisors to be significantly less pleasing than clinical year students, whilst clinical year students found a midline diastema significantly less pleasing than preclinical students.

Conclusions

Dental students at different stages of their undergraduate dental education have different perceptions of smile aesthetics. There was no evidence that the perception of dental attractiveness was affected by students’ ethnicities or location of upbringing.
TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
Authors: Lalic Tatjana , Steponenaite Aiste , Wei Liting , Vasudevan Sridhar R. , Mathie Alistair , Peirson Stuart N. , Lall Gurprit S. , Cader M. Zameel
Published: September 2020

The suprachiasmatic nucleus (SCN) is a complex structure dependent upon multiple mechanisms to ensure rhythmic electrical activity that varies between day and night, to determine circadian adaptation and behaviours. SCN neurons are exposed to glutamate from multiple sources including from the retino-hypothalamic tract and from astrocytes. However, the mechanism preventing inappropriate post-synaptic glutamatergic effects is unexplored and unknown. Unexpectedly we discovered that TRESK, a calcium regulated two-pore potassium channel, plays a crucial role in this system. We propose that glutamate activates TRESK through NMDA and AMPA mediated calcium influx and calcineurin activation to then oppose further membrane depolarisation and rising intracellular calcium. Hence, in the absence of TRESK, glutamatergic activity is unregulated leading to membrane depolarisation, increased nocturnal SCN firing, inverted basal calcium levels and impaired sensitivity in light induced phase delays. Our data reveals TRESK plays an essential part in SCN regulatory mechanisms and light induced adaptive behaviours.
The quantum-optical nature of high harmonic generation
Authors: Gorlach Alexey , Neufeld Ofer , Rivera Nicholas , Cohen Oren , Kaminer Ido
Published: September 2020

High harmonic generation (HHG) is an extremely nonlinear effect generating coherent broadband radiation and pulse durations reaching attosecond timescales. Conventional models of HHG that treat the driving and emitted fields classically are usually very successful but inherently cannot capture the quantum-optical nature of the process. Although prior work considered quantum HHG, it remains unknown in what conditions the spectral and statistical properties of the radiation depart considerably from the known phenomenology of HHG. The discovery of such conditions could lead to novel sources of attosecond light having squeezing and entanglement. Here, we present a fully-quantum theory of extreme nonlinear optics, predicting quantum effects that alter both the spectrum and photon statistics of HHG, thus departing from all previous approaches. We predict the emission of shifted frequency combs and identify spectral features arising from the breakdown of the dipole approximation for the emission. Our results show that each frequency component of HHG can be bunched and squeezed and that each emitted photon is a superposition of all frequencies in the spectrum, i.e., each photon is a comb. Our general approach is applicable to a wide range of nonlinear optical processes, paving the way towards novel quantum phenomena in extreme nonlinear optics.
Low elevation of Svalbard glaciers drives high mass loss variability
Authors: Noël Brice , Jakobs C. L. , van Pelt W. J. J. , Lhermitte S. , Wouters B. , Kohler J. , Hagen J. O. , Luks B. , Reijmer C. H. , van de Berg W. J. , van den Broeke M. R.
Published: September 2020

Compared to other Arctic ice masses, Svalbard glaciers are low-elevated with flat interior accumulation areas, resulting in a marked peak in their current hypsometry (area-elevation distribution) at  ~450 m above sea level. Since summer melt consistently exceeds winter snowfall, these low-lying glaciers can only survive by refreezing a considerable fraction of surface melt and rain in the porous firn layer covering their accumulation zones. We use a high-resolution climate model to show that modest atmospheric warming in the mid-1980s forced the firn zone to retreat upward by  ~100 m to coincide with the hypsometry peak. This led to a rapid areal reduction of firn cover available for refreezing, and strongly increased runoff from dark, bare ice areas, amplifying mass loss from all elevations. As the firn line fluctuates around the hypsometry peak in the current climate, Svalbard glaciers will continue to lose mass and show high sensitivity to temperature perturbations.
Transition metal dichalcogenide metamaterials with atomic precision
Authors: Munkhbat Battulga , Yankovich Andrew B. , Baranov Denis G. , Verre Ruggero , Olsson Eva , Shegai Timur O.
Published: September 2020

The ability to extract materials just a few atoms thick has led to the discoveries of graphene, monolayer transition metal dichalcogenides (TMDs), and other important two-dimensional materials. The next step in promoting the understanding and utility of flatland physics is to study the one-dimensional edges of these two-dimensional materials as well as to control the edge-plane ratio. Edges typically exhibit properties that are unique and distinctly different from those of planes and bulk. Thus, controlling the edges would allow the design of materials with combined edge-plane-bulk characteristics and tailored properties, that is, TMD metamaterials. However, the enabling technology to explore such metamaterials with high precision has not yet been developed. Here we report a facile and controllable anisotropic wet etching method that allows scalable fabrication of TMD metamaterials with atomic precision. We show that TMDs can be etched along certain crystallographic axes, such that the obtained edges are nearly atomically sharp and exclusively zigzag-terminated. This results in hexagonal nanostructures of predefined order and complexity, including few-nanometer-thin nanoribbons and nanojunctions. Thus, this method enables future studies of a broad range of TMD metamaterials through atomically precise control of the structure.
Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
Authors: Wang Rong , Yamada Tadaaki , Kita Kenji , Taniguchi Hirokazu , Arai Sachiko , Fukuda Koji , Terashima Minoru , Ishimura Akihiko , Nishiyama Akihiro , Tanimoto Azusa , Takeuchi Shinji , Ohtsubo Koshiro , Yamashita Kaname , Yamano Tomoyoshi , Yoshimura Akihiro , Takayama Koichi , Kaira Kyoichi , Taniguchi Yoshihiko , Atagi Shinji , Uehara Hisanori , Hanayama Rikinari , Matsumoto Isao , Han Xujun , Matsumoto Kunio , Wang Wei , Suzuki Takeshi , Yano Seiji
Published: September 2020

Drug tolerance is the basis for acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) including osimertinib, through mechanisms that still remain unclear. Here, we show that while AXL-low expressing EGFR mutated lung cancer (EGFRmut-LC) cells are more sensitive to osimertinib than AXL-high expressing EGFRmut-LC cells, a small population emerge osimertinib tolerance. The tolerance is mediated by the increased expression and phosphorylation of insulin-like growth factor-1 receptor (IGF-1R), caused by the induction of its transcription factor FOXA1. IGF-1R maintains association with EGFR and adaptor proteins, including Gab1 and IRS1, in the presence of osimertinib and restores the survival signal. In AXL-low-expressing EGFRmut-LC cell-derived xenograft and patient-derived xenograft models, transient IGF-1R inhibition combined with continuous osimertinib treatment could eradicate tumors and prevent regrowth even after the cessation of osimertinib. These results indicate that optimal inhibition of tolerant signals combined with osimertinib may dramatically improve the outcome of EGFRmut-LC.
Deep learning enabled smart mats as a scalable floor monitoring system
Authors: Shi Qiongfeng , Zhang Zixuan , He Tianyiyi , Sun Zhongda , Wang Bingjie , Feng Yuqin , Shan Xuechuan , Salam Budiman , Lee Chengkuo
Published: September 2020

Toward smart building and smart home, floor as one of our most frequently interactive interfaces can be implemented with embedded sensors to extract abundant sensory information without the video-taken concerns. Yet the previously developed floor sensors are normally of small scale, high implementation cost, large power consumption, and complicated device configuration. Here we show a smart floor monitoring system through the integration of self-powered triboelectric floor mats and deep learning-based data analytics. The floor mats are fabricated with unique “identity” electrode patterns using a low-cost and highly scalable screen printing technique, enabling a parallel connection to reduce the system complexity and the deep-learning computational cost. The stepping position, activity status, and identity information can be determined according to the instant sensory data analytics. This developed smart floor technology can establish the foundation using floor as the functional interface for diverse applications in smart building/home, e.g., intelligent automation, healthcare, and security.
Dual-crosslinked hyaluronan hydrogels with rapid gelation and high injectability for stem cell protection
Authors: Han Chenggang , Zhang Hua , Wu Yidong , He Xiuchao , Chen Xianwu
Published: September 2020

Injectable dynamic hydrogels play a key role in cell transplantation to protect the cells from shear stress during injection. However, it still remains challenging to design dynamic hydrogels with fast gelation and high stability for protecting cells under flow due to the slow formation and exchange of most dynamic bonds. Here, a novel dual-crosslinked hydrogel system with fast dynamic crosslinks is developed by using methacrylate chitosan (CHMA) and aldehyde functionalized hyaluronate (oxidized HA, OHA). Based on the cooperation of electrostatic interaction between cationic amino of chitosan and anionic carboxyl of HA and Schiff-based crosslinking through amino and aldehyde groups, the dynamic CHMA-OHA hydrogel shows rapid gelation and high injectability. Further, the CHMA-OHA hydrogel is photopolymerized for achieving a high modulus and stability. Importantly, such hydrogels loaded with stem cells remains a cell viability (~ 92%) after extrusion. These results indicate that the CHMA-OHA hydrogel is a promising tissue engineering biomaterial for therapeutic cell delivery and 3D printing of encapsulated cell scaffolds.
A customized scaffolds approach for the detection and phasing of complex variants by next-generation sequencing
Authors: Zeng Qiandong , Leach Natalia T. , Zhou Zhaoqing , Zhu Hui , Smith Jean A. , Rosenblum Lynne S. , Kenyon Angela , Heim Ruth A. , Eisenberg Marcia , Letovsky Stanley , Okamoto Patricia M.
Published: September 2020

Next-generation sequencing (NGS) is widely used in genetic testing for the highly sensitive detection of single nucleotide changes and small insertions or deletions. However, detection and phasing of structural variants, especially in repetitive or homologous regions, can be problematic due to uneven read coverage or genome reference bias, resulting in false calls. To circumvent this challenge, a computational approach utilizing customized scaffolds as supplementary reference sequences for read alignment was developed, and its effectiveness demonstrated with two CBS gene variants: NM_000071.2:c.833T>C and NM_000071.2:c.[833T>C; 844_845ins68]. Variant c.833T>C is a known causative mutation for homocystinuria, but is not pathogenic when in cis with the insertion, c.844_845ins68, because of alternative splicing. Using simulated reads, the custom scaffolds method resolved all possible combinations with 100% accuracy and, based on > 60,000 clinical specimens, exceeded the performance of current approaches that only align reads to GRCh37/hg19 for the detection of c.833T>C alone or in cis with c.844_845ins68. Furthermore, analysis of two 1000 Genomes Project trios revealed that the c.[833T>C; 844_845ins68] complex variant had previously been undetected in these datasets, likely due to the alignment method used. This approach can be configured for existing workflows to detect other challenging and potentially underrepresented variants, thereby augmenting accurate variant calling in clinical NGS testing.
Catalytic performance of the Ce-doped LaCoO3 perovskite nanoparticles
Authors: Ansari Anees A. , Adil Syed F. , Alam Manawwer , Ahmad N. , Assal Mohamed E. , Labis Joselito P. , Alwarthan Abdulrahman
Published: September 2020

A series of La1-xCexCoO3 perovskite nanoparticles with rhombohedral phases was synthesized via sol–gel chemical process. X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), Electron Diffraction Spectroscopy (EDS), Thermogravimetric Analysis (TGA), UV–Vis spectroscopy, Fourier Transform Infrared spectra (FTIR), Nitrogen Adsorption/desorption Isotherm, Temperature Program Reduction/Oxidation (TPR/TPO), X-ray Photoelectron Spectroscopy (XPS) techniques were utilized to examine the phase purity and chemical composition of the materials. An appropriate doping quantity of Ce ion in the LaCoO3 matrix have reduced the bond angle, thus distorting the geometrical structure and creating oxygen vacancies, which thus provides fast electron transportation. The reducibility character and surface adsorbed oxygen vacancies of the perovskites were further improved, as revealed by H2-TPR, O2-TPD and XPS studies. Furthermore, the oxidation of benzyl alcohol was investigated using the prepared perovskites to examine the effect of ceria doping on the catalytic performance of the material. The reaction was carried out with ultra-pure molecular oxygen as oxidant at atmospheric pressure in liquid medium and the kinetics of the reaction was investigated, with a focus on the conversion and selectivity towards benzaldehyde. Under optimum reaction conditions, the 5% Ce doped LaCoO3 catalyst exhibited enhanced catalytic activity (i.e., > 35%) and selectivity of > 99%, as compared to the other prepared catalysts. Remarkably, the activity of catalyst has been found to be stable after four recycles.
Koala immunogenetics and chlamydial strain type are more directly involved in chlamydial disease progression in koalas from two south east Queensland koala populations than koala retrovirus subtypes
Authors: Robbins Amy , Hanger Jonathan , Jelocnik Martina , Quigley Bonnie L. , Timms Peter
Published: September 2020

Chlamydial disease control is increasingly utilised as a management tool to stabilise declining koala populations, and yet we have a limited understanding of the factors that contribute to disease progression. To examine the impact of host and pathogen genetics, we selected two geographically separated south east Queensland koala populations, differentially affected by chlamydial disease, and analysed koala major histocompatibility complex (MHC) genes, circulating strains of Chlamydia pecorum and koala retrovirus (KoRV) subtypes in longitudinally sampled, well-defined clinical groups. We found that koala immunogenetics and chlamydial genotypes differed between the populations. Disease progression was associated with specific MHC alleles, and we identified two putative susceptibility (DCb 03, DBb 04) and protective (DAb 10, UC 01:01) variants. Chlamydial genotypes belonging to both Multi-Locus Sequence Typing sequence type (ST) 69 and ompA genotype F were associated with disease progression, whereas ST 281 was associated with the absence of disease. We also detected different ompA genotypes, but not different STs, when long-term infections were monitored over time. By comparison, KoRV profiles were not significantly associated with disease progression. These findings suggest that chlamydial genotypes vary in pathogenicity and that koala immunogenetics and chlamydial strains are more directly involved in disease progression than KoRV subtypes.
Factor analysis of acute kidney injury in patients administered liposomal amphotericin B in a real-world clinical setting in Japan
Authors: Takazono Takahiro , Tashiro Masato , Ota Yuki , Obata Yoko , Wakamura Tomotaro , Miyazaki Taiga , Nishino Tomoya , Izumikawa Koichi
Published: September 2020

Liposomal amphotericin B (L-AMB) is a broad-spectrum antifungal drug that is used to treat fungal infections. However, clinical evidence of its use in patients with renal failure is limited. Here, we aimed to identify factors associated with acute kidney injury (AKI) in patients administered L-AMB. We retrospectively utilized a combination of Diagnosis Procedure Combination data and laboratory data obtained from hospitals throughout Japan between April 2008 and January 2018. In total, 507 patients administered L-AMB were identified. After L-AMB treatment initiation, AKI, which was defined as a ≥ 1.5-fold increase within 7 days or ≥ 0.3 mg/dL increase within 2 days in serum creatinine according to the KDIGO criteria, was recognized in 37% of the total patients (189/507). The stages of AKI were stage 1 in 20%, stage 2 in 11%, and stage 3 in 7%. Five factors were associated with AKI of all stages: prior treatment with angiotensin-converting enzyme inhibitors/angiotensin-receptor blockers or carbapenem; concomitant administration of catecholamines or immunosuppressants; and ≥ 3.52 mg/kg/day of L-AMB dosing. Serum potassium < 3.5 mEq/L before L-AMB therapy was associated with severe AKI of stage 2 and 3. Altogether, these factors should be carefully considered to reduce the occurrence of AKI in patients administered L-AMB.
Noninvasive estimation of aortic hemodynamics and cardiac contractility using machine learning
Authors: Bikia Vasiliki , Papaioannou Theodore G. , Pagoulatou Stamatia , Rovas Georgios , Oikonomou Evangelos , Siasos Gerasimos , Tousoulis Dimitris , Stergiopulos Nikolaos
Published: September 2020

Cardiac and aortic characteristics are crucial for cardiovascular disease detection. However, noninvasive estimation of aortic hemodynamics and cardiac contractility is still challenging. This paper investigated the potential of estimating aortic systolic pressure (aSBP), cardiac output (CO), and end-systolic elastance (Ees) from cuff-pressure and pulse wave velocity (PWV) using regression analysis. The importance of incorporating ejection fraction (EF) as additional input for estimating Eeswas also assessed. The models, including Random Forest, Support Vector Regressor, Ridge, Gradient Boosting, were trained/validated using synthetic data (n = 4,018) from an in-silico model. When cuff-pressure and PWV were used as inputs, the normalized-RMSEs/correlations for aSBP, CO, and Ees(best-performing models) were 3.36 ± 0.74%/0.99, 7.60 ± 0.68%/0.96, and 16.96 ± 0.64%/0.37, respectively. Using EF as additional input for estimating Eessignificantly improved the predictions (7.00 ± 0.78%/0.92). Results showed that the use of noninvasive pressure measurements allows estimating aSBP and CO with acceptable accuracy. In contrast, Eescannot be predicted from pressure signals alone. Addition of the EF information greatly improves the estimated Ees. Accuracy of the model-derived aSBP compared to in-vivo aSBP (n = 783) was very satisfactory (5.26 ± 2.30%/0.97). Future in-vivo evaluation of CO and Eesestimations remains to be conducted. This novel methodology has potential to improve the noninvasive monitoring of aortic hemodynamics and cardiac contractility.
Author Correction: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery
Authors: Kunjachan Sijumon , Kotb Shady , Pola Robert , Pechar Michal , Kumar Rajiv , Singh Bijay , Gremse Felix , Taleeli Reza , Trichard Florian , Motto-Ros Vincent , Sancey Lucie , Detappe Alexandre , Yasmin-Karim Sayeda , Protti Andrea , Shanmugam Ilanchezhian , Ireland Thomas , Etrych Tomas , Sridhar Srinivas , Tillement Olivier , Makrigiorgos Mike , Berbeco Ross I.
Published: September 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Structural elucidation of microcrystalline MOFs from powder X-ray diffraction
Authors: Martí-Rujas Javier
Published: September 2020

Ab initiopowder XRD structure solution and MOFs.
Optical thermometry based on the thermally coupled energy levels of Er3+ in upconversion materials
Authors: Xiang Guotao , Xia Qing , Liu Xiaotong , Wang Xiaojun
Published: September 2020

Fluorescence intensity ratio technology based on the thermally coupled energy levels of Er3+ is a promising strategy for optical thermometry.
Free carrier enhanced depletion in ZnO nanorods decorated with bimetallic AuPt nanoclusters
Authors: Bahariqushchi R. , Cosentino S. , Scuderi M. , Dumons E. , Tran-Huu-Hue L. P. , Strano V. , Grandjean D. , Lievens P. , Poulin-Vittrant G. , Spinella C. , Terrasi A. , Franzò G. , Mirabella S.
Published: September 2020

AuPt nanocluster decoration of ZnO nanorods augments dark resistance (500×) and UV light sensitivity (10×) much more than Au or Pt decoration.
Green chemical mechanical polishing of sapphire wafers using a novel slurry
Authors: Xie Wenxiang , Zhang Zhenyu , Liao Longxing , Liu Jie , Su Hongjiu , Wang Shudong , Guo Dongming
Published: September 2020

Toxic and corrosive solutions are widely used in the preparation of abrasives and chemical mechanical polishing (CMP) of sapphire wafers, resulting in potential environmental pollution.