bluuebunny/crossref_metadata_2025 huggingface dataset:
About the Risks of Developmental Disorders in Early Life and Their Prevention
Authors: Kholodova O.L. , Kuzmenko M.Yu. , Arbekova O.A.
Published: February 2024

The article shows the foreign experience of the approach to creating conditions for the development of an early age child, including children with disabilities. The factors of early childhood development, as well as the risks for development and their prevention are considered. Using the example of successful practices, it is discussed what educational conditions are to be created for the development of toddlers, especially for social and emotional development in groups of young children, including integration formats to promote the child's own research activity, free play and movement, interaction with other children and adults. Special attention is paid to the prevention of the risks of developmental disorders, the peculiarities of working with children with disabilities, the role of the teacher and his/her interaction with the child in the group — the style of communication, the use of speech, the peculiarities of assistance and support to the child's own activity and the development of his/her selfdependence. The principal trends of the modern approach to creating conditions in the group for the development of young children in foreign practice are highlighted: the importance of the quality of interaction, scaffolding, the creation of a subject-based developing environment, the synthesis of achievements of various psychological and pedagogical theories, the attitude to dialogue and cooperation with parents, the possibility of inclusion. In terms of creating conditions for children with disabilities and early intervention, individual classes are more often used, less frequently group classes, the format of integrative groups with typically developing children is promising, while active interaction and cooperation with parents is important. The principal trends of the modern approach to creating conditions in the group for the development of young children in foreign practice are highlighted: the importance of the quality of interaction, scaffolding, the creation of a subject-based developing environment, the synthesis of achievements of various psychological and pedagogical theories, the attitude to dialogue and cooperation with parents, the possibility of inclusion. In terms of creating conditions for children with disabilities and early intervention, individual classes are more often used, less often group classes, the format of integrative groups with normotypically developing children is promising, while active interaction and cooperation with parents is important.
Library of Adolescent Socialization Programs: Methodology and Procedure of Register Formation
Authors: Gani С.В. , Podushkina T.G. , Pavshenko E.A.
Published: February 2024

The article analyzes the experience of creating a thematic register of adolescent socialization programs based on the principles of an evidence–based approach — the Library of Practices of the Federal Adolescent Center. The principles of allocation of criteria for the analysis of competitive programs, as well as the design of Library sections based on the “Standard of Evidence of Practices in the Sphere of Childhood” are considered. The spectrum of socialization difficulties that modern adolescents face, highlighted by the authors of the programs, is discussed; the target groups of adolescents to work with whom the programs are directed. Conclusions are drawn that the evidence of effectiveness presented in the description of most programs is currently insufficient to confirm the social results claimed by the authors; about the need to organize scientific and methodological support and verification of results in the framework of research for both part of the programs already presented in the library and for the applicant programs. Conclusions are also drawn about the possibilities of practical application of the Library of Practices.
Correlation between Strain Rate and Seismicity in Different Tectonic Settings
Authors: Chen Yuxuan , Liu Mian
Published: February 2024

Geodetic strain rate characterizes present-day crustal deformation and therefore may be used as a spatial predictor for earthquakes. However, the reported correlation between strain rates and seismicity varies significantly in different places. Here, we systematically study the correlation between strain rate, seismicity, and seismic moment in six regions representing typical plate boundary zones, diffuse plate boundary regions, and continental interiors. We quantify the strain rate–seismicity correlation using a method similar to the Molchan error diagram and area skill scores. We find that the correlation between strain rate and seismicity varies with different tectonic settings that can be characterized by the mean strain rates. Strong correlations are found in typical plate boundary zones where strain rates are high and concentrated at major fault zones, whereas poor or no correlations are found in stable continental interiors with low strain rates. The correlation between strain rate and seismicity is also time dependent: It is stronger in seismically active periods but weaker during periods of relative quiescence. These temporal variations can be useful for hazard assessment.
The pineal gland and its neurosecretory product, melatonin.
Authors: Smith David
Published: February 2024

The pineal gland was appreciated as a distinct anatomical entity from antiquity associated with a role in mysticism and in religion as the seat of the soul. The gland appears to have had a photoreceptive role earlier in evolution but typical of vertebrate adaptability it has undergone a role change to a secretory organ with changing needs of the organism. In the contemporary settling it is now known for its neuroendocrine product, melatonin and its association with the sleep cycle. An ancient pleiomorphic molecule with a range of attributes but its antioxidant properties, which helped organisms survive oxygenation of the atmosphere at the dawn of time, is still relevant today, providing an extra layer of protection to the organism as whole but particularly the brain, mitochondria and the skin. Melatonin, through its seasonal influence on the immune function, may also affect disease susceptibility.
Dose Selection for Clinical Development in the Treatment of Hypertension: The Aprocitentan Case and Lessons from the Past
Authors: M Bellet , G Braunstein , P Verweij , P Danaietash , M Iglarz , B Flamion
Published: February 2024

Dose selection plays a critical role in the clinical development of a drug. This current review highlights the lessons learned from previous dose finding studies (DFSs) of antihypertensive drugs and from the recent example of aprocitentan, a novel endothelin receptor antagonist for the treatment of resistant hypertension. Based on these, the authors provide 10 key recommendations for an efficient DFS for a new antihypertensive medication. These recommendations respect critical comments repeatedly made by the U.S. Food and Drug Administration (FDA) Division of Cardiology and Nephrology over the last 5 decades and go beyond the more limited recommendations made in the 2016 Committee for Medicinal Products for Human Use (CHMP) guideline on the development of new antihypertensive medications. The added value of a dose-response modelling approach enriches prior regulatory advice on DFSs.
The tumour thiolome as a potential target for anticancer drug development - time for a re-valuation of this area of cancer research.
Authors: Gronow Michael
Published: February 2024

This review is concerned with the role of various thiol constituents of the eukaryote cellular thiolome, particularly the part they play in the metabolism of tumour cells. The thiolome can be divided into two sections of high and low molecular weight thiol moieties and these are discussed. The impact of the discovery of high concentrations of a new unknown low molecular weight thiol in a tumour thiolome is also discussed. Its presence may have important ramifications in the search for new and more effective chemotherapeutic drugs to treat metastatic tumour cell growths.
Introduction. - In this review, one of the mechanisms that is generated in inflammation, oxidative stress, was analyzed. Inflammation is an immune system response, it is essential for survival and recovery, but it can cause damage to the body, due to oxid
Authors: Vargas-Campos Luis-Eder , Adams-Reyes Marco-A. , Adams-Ocampo Julio-Cesar , Gomez Juan-Manuel , Medina-Rojas Yanet Medina-Rojas , Vargas-Zuñiga Luis-Martin
Published: February 2024

Introduction. - In this review, one of the mechanisms that is generated in inflammation, oxidative stress, was analyzed. Inflammation is an immune system response, it is essential for survival and recovery, but it can cause damage to the body, due to oxidative stress that occurs when there is an imbalance between the production of reactive oxygen species and the body's ability to neutralize them with Endogenous antioxidants contribute to the development of chronic diseases such as cardiovascular, diabetes, autoimmune diseases, cancer, neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis. Aim. - Evaluate the literature about Inflammation from the basic to the clinical. Methodology. - Databases such as MEDLINE/PubMed and ScienceDirect regarding Inflammation were analyzed. Results. - Despite recent advances in the understanding of inflammation and oxidative stress, there are still important challenges in the study and treatment of these conditions, on the one hand, it is necessary to develop more precise biomarkers to evaluate oxidative stress and inflammation in the patients. While in the other, new therapeutic approaches are needed to modulate inflammation and oxidative stress more effectively and specifically. Conclusion. - That the study of inflammation and oxidative stress is crucial to understanding the pathophysiological bases of various chronic diseases and that advances in the field of inflammation and oxidative stress have provided new therapeutic perspectives for the treatment and prevention of chronic diseases.
Legal regulations of television presidential debates
Authors: Klejny Michał
Published: February 2024

W artykule przedstawiono analizę regulacji prawnej zawartej w art. 120 Kodeksu wyborczego oraz w rozporządzeniu Krajowej Rady Radiofonii i Telewizji w sprawie szczegółowych zasad i trybu przeprowadzania debat przez Telewizję Polską Spółkę Akcyjną, do którego artykuł ten odsyła. Po dokonaniu zarysu genezy telewizyjnych debat prezydenckich w Polsce i na świecie badaniu poddano poziom szczegółowości regulacji oraz praktykę jej stosowania od wejścia w życie w 2011 roku w kolejnych kampaniach wyborczych w latach 2015 i 2020 przed obiema turami wyborów. Zastosowana metoda badawcza polegała na stopniowej analizie materiału źródłowego w postaci nagrań debat telewizyjnych, w szczególności: debaty pomiędzy Johnem Kennedym i Richardem Nixonem z 1960 roku, debaty Mieczysława Rakowskiego z pracownikami Stoczni Gdańskiej z 1983 roku, debaty Lecha Wałęsy z Alfredem Miodowiczem z 1988 roku oraz wszystkich późniejszych polskich debat prezydenckich. Analiza była ukierunkowana na odnalezienie kluczowych elementów z punktu widzenia zasad funkcjonowania systemu demokratycznego. Badanie obecnej regulacji połączono z próbą zdefiniowania minimalnych wymogów debaty oraz określeniem jej znaczenia dla demokratycznej kampanii wyborczej. W dalszej części pracy wskazano na możliwe obszary wymagające dalszej regulacji. Zwrócono także uwagę na zagrożenia, jakie niesie za sobą brak określonych zasad funkcjonowania systemu demokratycznych wyborów, z wyszczególnieniem zasady równości wśród kandydatów. Na podstawie analizy debat również z wcześniejszych lat podjęto także próbę wyodrębnienia dobrych praktyk debat telewizyjnych, które w największym stopniu chroniły cele, jakim służyć ma ta forma dyskusji.
Independence of the Polish electoral administration – de lege lata remarks and de lege ferenda postulates
Authors: Rydel Konrad , Kaczmarczyk Marek Piotr
Published: February 2024

Do 2018 roku sposób zorganizowania polskiej administracji wyborczej zapewniał jej bezstronność i niezależność. Na mocy nowelizacji Kodeksu wyborczego dokonanej w 2018 roku administracja wyborcza stała się znacznie bardziej podatna na wpływy polityków. Wysoki poziom upolitycznienia jest widoczny szczególnie w przypadku sposobu obsadzenia PKW.
Zwiększenie wpływu czynnika politycznego dotyczy również sposobu obsadzania niektórych komisji wyborczych. Ustawodawca odszedł zarazem od sędziowskiego modelu administracji
wyborczej. W artykule autorzy opisali zagrożenia dla polskiego systemu prawnego związane z upolitycznieniem tych organów. Obecnie obowiązujące przepisy Kodeksu wyborczego zwiększają możliwość ingerowania w funkcjonowanie systemu demokratycznego przez polityków, czego przykładem jest możliwość odrzucania sprawozdań finansowych partii politycznych przez PKW. Szansy na zwiększenie niezależności administracji wyborczej autorzy upatrują głównie w konstytucjonalizacji PKW. W pracy zastosowano metodę formalno-dogmatyczną oraz teoretyczno-prawną, a także metodę krytycznej analizy źródeł oraz argumentacyjną, co pozwala na konstruktywną krytykę omawianych rozwiązań.
In vitro evaluation of microencapsulated Bacillus thuringiensis exposed to different temperatures against Helicoverpa armigera (Hubner)
Authors: AKSHAYA KUMAR K. , KALMATH BASAVARAJ S. , HADIMANI D. K. , PRABHURAJ A. , MALLIKARJUNA S. , KISAN B.
Published: February 2024

The experiment was conducted to prepare and evaluate microencapsulation of lyophilized Spore Crystal Aggregate (SCA) of native Bacillus thuringiensis isolate BGC-1 and standard isolate HD-1 against second instar larvae of Helicoverpa armigera at the Department of Agricultural Entomology, Bheemarayanagudi. The zetasizer analyzer results revealed that the microcapsule diameter ranged from 3.2 to 8.3 µm. Median lethal concentrations of the BGC-1 and Bt-HD1 were 0.66 g/l and 0.50 g/l, respectively. UV protectants viz., melanin and (PABA) para-amino benzoic acid were evaluated by exposing microencapsulated Bacillus thuringiensis to temperature regimes of 25°C, 30°C, 35°C, 40°C and 45°C in the B.O.D at different intervals of time. Among four microencapsulated formulations, BGC-1 with melanin recorded the highest mortality of 95 % at zero h exposure. As time increased, the mortality decreased and HD-1 was on par with BGC-1. HD-1 melanin showed significantly higher mortality of 62.50 to 92.50 % followed by BGC-1 (melanin) which ranged from 70 to 90 %. Even though formulations were exposed to different temperatures, because of encapsulation, potential to cause insect mortality was retained.
Effect of augmentative releases of the parasitoid, Habrobracon hebetor Say (Hymenoptera: Braconidae) using plastic cups on Heliocheilus albipunctella De Joannis (Lepidoptera: Noctuidae) in the Sahelian region of Burkina Faso
Authors: KABORE ADAMA , BOLY ABOUBACAR , WAONGO ANTOINE , SANOU APOLLINE , TRAORE FOUSSENI , DABIRE-BINSO CLEMENTINE , SANON ANTOINE , BA MALICK NIANGO
Published: February 2024

The most important insect pest of the millet crop in Burkina Faso is the Millet Head Miner (MHM), Heliocheilus albipunctella De Joannis (Lepidoptera: Noctuidae). To reduce its damage, the use of the parasitoid, Habrobracon hebetor Say (Hymenoptera: Braconidae) constitutes the most promising control strategy. The present study aims to know the effect of augmentative releases of H. hebetor on this pest using a new parasitoid release technique. This new technique release consists of a recycled plastic cups containing Corcyra cephalonica Stainton larvae parasitized individually at different times (8, 12 and 24 hours) by H. hebetor females. These cups were installed in the millet fields of different villages (release villages) to control this pest H. albipunctella by H. hebetor, and maitained the control villages that didn’t receive any release. Our findings showed that plastic cups containing parasitized larvae at different times can be used to produce parasitoids. Thus, C. cephalonica larvae parasitized in 24 hours produced 280 H. hebetor, unlike larvae parasitized in 8 and 12 hours. Emerged H. hebetor had a male-biased sex ratio when the time of parasitism of C. cephalonica larvae by H. hebetor females was 24h. Releasing parasitoids into millet fields reduced the length of mines by 3.80 cm and two times higher parasitism of the pest by H. hebetor in the villages where parasitoids were released as compared to control villages. Finally, a millet yield gain of 31% was obtained in the parasitoid released fields. This new release technique of H. hebetor could be used in biological control programmes against MHM in the Sahel.
Investigation of Rutting and Low Temperature Cracking Behavior of Reactive Ethylene Terpolymer and Waste Cooking Oil Modified Bitumen
Authors: Kumandaş Aytuğ , Çavdar Erman , Şahan Neslihan , Kök Baha , Pancar Erhan Burak , Oruç Şeref
Published: February 2024

With sustainability being the most crucial issue of recent years, the use of waste materials in bitumen modification is increasing and becoming widespread. In this experimental study, it was aimed to investigate the high- and low-temperature behavior of bitumen samples modified with waste cooking oil (WCO), reactive ethylene terpolymer (RET), and polyphosphoric acid (PPA). Accordingly, the multiple stress creep and recovery (MSCR) test and the bending beam rheometer (BBR) test were conducted. Depending on the increasing WCO ratio, the Jnr,R%,∆T_c,and λ parameters of modified bitumens were examined in detail. It was observed that with increasing WCO ratio,the Jnr value increased, and elastic recovery and stiffness decreased. In addition, it has been determined that this composite-modified bitumen is resistant to heavy traffic loads and has sufficient flexibility at low temperatures.
Determinants of intrapreneurial intention of small tea exporters in Sri Lanka
Authors: Wijetunge Wijetunge Arachchige Deepani Sajeewa , Yusoff Siti Khalidah Binti Md , Azam Ferdous , Tham Jacquline
Published: February 2024

The purpose of the study is to investigate the factors affecting the intrepreneurial intentions of small tea exporters in Sri Lanka. Intentions are crucial in any behavior to realize such behaviors and yield expected results. Owing to the problem of this study as how to initiate innovations in the global tea market, the study was carried out to find out the determinants of intentions of small tea exporters in Sri Lanka. This is a quantitative study followed by deductive reasoning. This study selected small tea exporters with the view of enhancing their intentions to proceed with these innovations, as large tea exporters are already introducing innovations to the tea industry. The study collected data from 120 small tea exporters who had registered with the Sri Lanka Tea Board by the end of 2020 using a structured questionnaire. The findings revealed that Individual Entrepreneurial Orientation (IEO), attitudes, and Entrepreneurial Self-efficacy (ESE) have significant and positive impact on Intrapreneurial Intention (INI) of small tea exporters in Sri Lanka while IEO contributes more to the INI. Finally, the findings of this study provide useful insights for small tea exporters in stimulating their intentions towards the introduction of innovations leading to a better performance in the global tea market. Further, it will guide policymakers and the government in designing the appropriate policies, rules, and regulations in this context.
PARA ALÉM DE UM RITO DE PASSAGEM: REVISTANDO O NOIVADO COMO OBJETO DE PESQUISA NAS CIÊNCIAS SOCIAIS
Authors: ALENCAR Breno Rodrigo de Oliveira
Published: February 2024

This article is a critical review of a paper published in the same journal in 2014. Through it I present the results of my doctoral thesis in which I revisited the theme of engagement in order to discuss its place in the collective imagination and in socioanthropological research. To achieve this goal, the article was divided into two sections. The first problematizes the engagement as an object of study pointing out, by means of demographic data, publications in the press, the emergence of the wedding industry and the institutionalization of engagement courses, that bridal ritualization is a constant theme in the social sciences with a wide range of interpretative clippings. As a consequence, the second section is concerned with approaching engagement from the perspective of kinship studies seeking to discuss both its typology and its theoretical relevance
RESISTIR É PUBLICAR. A REVISTA MARGENS COMO TERRITÓRIO DE PRODUÇÃO CIENTÍFICAS NAS CIDADES E TERRITÓRIOS AMAZÔNICOS
Authors: SARMENTO-PANTOJA Augusto , TELES Eliana
Published: February 2024

This text was born as a farewell manifeste for the years of work at Margens magazine, when we tried to implement a new path for scientific publishing in the cities and territories of the Amazon. In this text I reflect on the gains we have made and the challenges that continue to be posed to those who are taking on the task of maintaining the magazine as the most important scientific journal published in a medium-sized city in the Amazon.
Péptido antimicrobiano AP7121: inhibición de adhesión bacteriana en catéteres vasculares
Authors: Lissarrague Sabina , Schofs Laureano , Bistoletti Mariana , García Allende Leonardo , Lallée Andrea , Baldaccini Beatriz , Sánchez Bruni Sergio , Sparo Monica
Published: February 2024

Las infecciones del torrente sanguíneo asociadas a los cuidados de la salud constituyen una de las principales causas de morbilidad y mortalidad. La infección relacionada con catéteres vasculares es su fuente principal. Las bacterias Gram positivas, especialmente Staphylococcus spp., constituyen uno de los agentes etiológicos más frecuentes. Objetivo: evaluar la actividad inhibitoria del AP7121 sobre la adherencia de Staphylococcus aureus en catéteres vasculares. Se utilizó la cepa productora de biofilm S. aureus ATCC 35556 (SA). Se estimó CIMAP7121 para SA, se inocularon segmentos de 20 mm de catéter vascular (n=3) con 104 UFC mL-1 de SA. Se probaron tres esquemas diferentes (A: simultáneo, B: anterior y C: después del desafío bacteriano) utilizando 1 x CIMAP7121. Se incluyeron grupos de control en cada esquema. La CIMAP7121 fue 0,48 mg/L. Con los esquemas A y B se logró una reducción de 2 logaritmos que representa una disminución del 99 % de células viables. El tratamiento posterior a la exposición con AP7121 (esquema C) produjo una reducción de 1 logaritmo que representa una disminución del 90 % de células viables. Estos resultados sugieren una rápida actividad antimicrobiana de AP7121 que podría ser beneficiosa para reducir la adherencia bacteriana en catéteres vasculares.
Estabilidad dinámica de miembros inferiores en basquetbolistas con y sin discapacidad auditiva según protocolo de McGuill y Test de la Y
Authors: Hincapié Gallón Olga Lucía , Tierradentro Gómez Lina Marcela , Bravo Romero Daniela , Córdoba Peña Nathalia
Published: February 2024

Introducción: La estabilidad dinámica es la habilidad de conservar una condición estable estática sobre una base de sustentación luego de una transición dinámica, por tanto, es relevante en el baloncesto por los cambios de dirección, aceleración y desaceleración, hecho que afecta tanto deportistas con y sin discapacidad auditiva. Objetivo: Identificar características relacionadas con la estabilidad dinámica de miembros inferiores en basquetbolistas con y sin discapacidad auditiva. Método: Estudio descriptivo en deportistas con y sin discapacidad auditiva entre los 18 a 45 años de edad del Valle del Cauca. Se evaluaron variables sociodemográficas, clínicas, antropométricas, antecedentes, estabilidad dinámica con el Test de la Y y resistencia de core con el protocolo de McGuill.  Resultados: No se encontraron diferencias significativas en la variable de estabilidad dinámica en los deportistas con y sin discapacidad auditiva, sin embargo, 2 deportistas, con y sin discapacidad auditiva obtuvieron un compuesto por encima del promedio. Para la variable de resistencia de los músculos del core, se obtuvo mayores tiempos en la prueba de decúbito lateral izquierdo que en el derecho, siendo este su lado dominante. Conclusión: Los resultados diversos invitan a mantener el principio de individualización en la evaluación y abordaje de los deportistas.
Estudio del patrimonio cultural y natural del Ecuador desde un enfoque turístico
Authors: Carrera Bravo Maria  Annabelle , Cobeña Macías Eliana Carolina , Ordoñez `Piedra Juan Carlos , Zambrano Wendy Stefanía
Published: February 2024

El patrimonio turístico cultural del Ecuador es variado, eso lo convierte en un destino atractivo para personas de todo el mundo. Este se puede clasificar en diferentes categorías: histórico, arqueológico, religioso, gastronómico y natural. El acervo histórico y arqueológico del país resulta importante porque cuenta con gran cantidad de elementos de este tipo. Entre los más resaltantes están la ciudad de Quito, declarada Patrimonio de la Humanidad por la UNESCO; el Complejo Arqueológico Ingapirca; y, la ciudad de Cuenca. El patrimonio religioso también es significativo, pues es profundamente valorado; cuenta con numerosos templos y demás instalaciones de valor turístico como la Basílica del Voto Nacional y el Monasterio de San Francisco, en Quito y la catedral de Cuenca en Azuay. Además, el país dispone de una variedad de paisajes naturales. El objetivo de este trabajo es contribuir al estudio del patrimonio turístico cultural y natural del Ecuador, y ofrecer al lector un documento de ayuda para conocer mejor la riqueza que este tiene. Se desarrolló desde una revisión de 43 trabajos, de la cual se obtuvo información de 22, todos alojados en bases de datos diversas, considerando prioritarias las de publicación reciente; Igualmente, se consultaron documentos de sitios web de instituciones afines al tema, entre ellos del Ministerio de Turismo y el Instituto Nacional de Patrimonio Cultural. Los resultados de la revisión muestran amplia información relacionada con los bienes patrimoniales nacionales. Se concluye que estos son de capital importancia para el aprovechamiento del turismo en sus diversas modalidades.
Comprehensive Assessment of Lead Bioaccumulation in Helix aspersa (Müller, 1774), Snails: A Study of Histopathological and Biochemical Impacts
Authors: Nadji S. , Boulkenafet F. , Benzazia S. , Mellah L. , Bououza F. , Al-Mekhlafi F.A. , Al-Khalifa M.S. , Lambiase S.
Published: February 2024

Background: The snail Helixa spersa is considered a relevant bioindicator of soil pollution by metallic elements due to its resistance and accumulation capabilities. Methods: This study aims to determine the dose-response relationship between different concentrations of lead and its toxic effects on juvenile H. aspersa through a semi-static ecotoxicity test under controlled conditions. In addition, continuous monitoring of carbohydrates, lipids and proteins of the snails affected by this metal was evaluated along with a histopathological study of the hepatopancreas. Result: The two-month lead exposure in H. aspersa resulted in significant alterations in biochemical and histological parameters. Lead concentrations in the hepatopancreas and foot exhibited a dose-dependent increase, with higher levels observed in the former. Elevated lead concentrations (1000 ìg/g and 1500 ìg/g of soil) led to substantial protein increase in both organs, while even lower doses displayed considerable protein elevation in the hepatopancreas. Carbohydrate levels were significantly lower in all contaminated groups compared to controls. Increasing lead concentrations caused a reduction in lipid levels. Histological analysis revealed distinct alterations, including excretory cell hypertrophy, tubule clustering and inflammatory changes in the hepatopancreas of treated snails. Severe histological damage, including inflammatory infiltrates, cellular debris and necrosis, were observed at higher lead concentrations (1000 and 1500 ìg/g). These findings emphasize the impact of lead exposure on biochemical profiles and organ histology in H. aspersa, highlighting the potential ecological implications of heavy metal contamination.
Effect of Parent’s International Migration on the Educational Performances of Left-Behind Children in Morocco
Authors: El Alaoui Aicha , Ahbala Salah
Published: February 2024

This study tries to examine the effects of parent’s international migration on educational outcomes of left-behind children, focusing especially On the relative importance of family environment and school characteristics to educational achievements of left-behind children. For that, a sample from the survey study in Fkih Ben Salah as a small town in Morocco, located in the Béni Mellal-Khénifra region. This survey is administered in 2020 on 407 children from 16 primary school. The results of the prospensity score matching method showed that the internzationale migration of parents had a significant effect on the school performance of their left behind children ;furthermore ,the analysis using the Oaxaca - Blinder decomposition showed that 36.34% of the differences in the children’s school performance in first semester for year of 2020 can be explained by student–teacher ratio, size class and socio-economic index of class are 12.82%,38.47% and 31.35% of the gap, respectively. The empirical findings reveal also that Left behind children are at risk of facing social exclusion, especially in public schools.
Assessing the Relationship between Short Birth-to-Pregnancy Interval and the Maternal and Perinatal Outcomes among Multiparous Women in Northern Ghana
Authors: Agulu Gilbert G. , Dzotsi Emmanuel K. , Issah Kofi , Nyuzaghl Josephat A. , Adogboba Alemna D. , Adongo Vincent A.
Published: February 2024

Introduction: The World Health Organization (WHO) recommends an optimal Birth-to-Pregnancy Interval (BPI) of 24-59 months, or a 33- month interval between two successive births to reduce the risk of untoward maternal and newborn outcomes. Short Birth to Pregnancy Interval (SBPI), and unmet need for Family Planning (FP) are the major contributors to rapid population growth and increased maternal and newborn mortalities. The purpose of this study was to assess the adverse perinatal and maternal outcomes associated with SBPI among multiparous women in three municipalities of the Upper East Region (UER) of Ghana. Materials and Methods:The study employed the Cross-sectional Design conducted among 904 women aged 15-49 years attending Antenatal Care (ANC) clinics in three municipalities in the UER who had at least two successive live births prior to data collection. Data was collected using structured questionnaire, incorporated into the electronic data collection tool, Kobo collect and administered by trained research assistants. Birth interval was categorized according to the WHO’s classification, <24 months as SBPI, 24-≥59 months as Optimal Birth to Pregnancy Interval (OBPI) and >59 months as Long Birth to Pregnancy Interval (LBPI). Results: Of the 904 respondents, the majority (56.2%) had an OBPI, while 36.9% had a SBPI. Factors that influenced SBPI were parity, mode of delivery, and the educational status of women’s partner. Participants with a higher parity (≥5 children) had 0.67 times the potential of spacing their births (AOR 0.67; 95% CI 0.46-0.98; p = 0.040). Women who experienced a Caesarean Section (CS) delivery were 3.28 times more likely to have LBPI (AOR 3.28; 95% CI 1.02-10.62; p=0.047). Respondents whose partners had secondary education had a 1.87 chance (AOR 2.07; 95% CI 1.09-3.96; p=0.027) of spacing their births. The birth complications reported were retained products of conception (41.9%), pregnancy-induced hypertension (27.9%), postpartum hemorrhage (11.6%), obstructed labor (10.5%), sepsis (38.1%), neonatal jaundice (23.8%), lowbirth-weight (19%), and preterm birth (14.3%). Conclusion and Global Health Implications: The study recommends health professionals in direct contact with maternal, reproductive, and child health to be proactive in FP counseling, and to support women decision making.
Temporal Variability of Rainfall Amounts and Trend Analysis in the Melloulou Watershed
Authors: Yassine Bertal , Youssef Ben Brahim
Published: February 2024

The present study consists in analyzing the temporal variability of rainfall and rainfall trend a statistical analysis of rainfall data in the Melloulou watershed for a half-century chronicle (1970-2020). The objective of this study is to extract all the rainfall characteristics of this period, to extract the rainfall variability and to determine the rainfall trends. The working method is based on a statistical approach to detect the climatic characteristics of the Melloulou basin. The study of the standardized precipitation index (SPI) and the rainfall deficit index (IDF) showed the alternation of very long dry periods with wet periods. The Mann-Kendall test under the RStudio also showed a decreasing rainfall trend.
Somnolencia Excesiva Diurna, tiempo de sueño y jetlag social en estudiantes universitarios
Authors: Morales-Sánchez Ana Karen , Padrós-Blázquez Ferran , Villuendas-González Erwin Rogelio
Published: February 2024

Introducción: La somnolencia diurna, como tendencia fisiológica a iniciar el sueño durante el día, se ha relacionado con diversas variables como calidad de sueño, tiempo de sueño y la regularidad en los horarios de sueño. Sin embargo, en los estudios sobre somnolencia diurna llevados a cabo en población universitaria no es frecuente que se considere como variable de estudio el tipo de días (hábiles o de descanso). Objetivo: Estudiar la relación entre las horas de sueño y jetlag social con los niveles de Somnolencia Diurna en estudiantes universitarios. Método: Los participantes respondieron un formulario online para recabar tiempos de sueño y nivel de somnolencia (Escala Epworth) y a partir de esos datos se calculó el nivel de jetlag social. Resultados: El promedio de horas de sueño en días lectivos fue mayor que en los fines de semana (t(225 ) = 13.66; p < .001; d = 1.05), y se encontró una correlación negativa entre niveles de somnolencia diurna y las horas de sueño. Discusión: Los estudiantes universitarios mexicanos refieren horas de sueño dentro del margen recomendado, sin embargo, han desarrollado diferentes tiempos de sueño por tipo de día y ello puede prolongarse a través del tiempo si las exigencias sociales no se revisan y reestructuran en pro de la salud integral.
Modelos central y atribucional de la percepción estudiantil de la enseñanza y de su aprendizaje
Authors: Cáceres-Bauer Roberto Daniel , Rodríguez-Morales Pilar Cecilia , Luzardo-Verde Marío Javier
Published: February 2024

Introducción: Se presenta el modelo central de la percepción del estudiante que ofrece una caracterización general de su percepción y del papel de esta en la relación entre la enseñanza, el aprendizaje y el contexto, desde una perspectiva socio-cognitiva. También, se presenta el modelo atribucional de la percepción del estudiante, que se basa en el modelo central  e integra la mirada de la teoría atribucional de Weiner. Antecedentes: El aporte teórico realizado se basa en el análisis de la percepción del estudiante desde la mirada de la psicología social cognitiva y teorías socio-cognitivas de la motivación, y un enfoque substantivo a la validez de constructo. Discusión: Los modelos presentados  ofrecen un marco conceptual útil para la investigación de la calidad de la enseñanza y el  aprendizaje, el desarrollo y validación de instrumentos y en evaluación educativa.
Género y citación en el discurso académico-científico
Authors: Esquivel Moreno Lucero Itzel , Velásquez Upegui Eva Patricia
Published: February 2024

En años recientes, el estudio de la citación en el discurso académico-científico ha permitido identificar desigualdades en cuanto a hombres y mujeres, ya que los trabajos de estas últimas suelen ser menos reconocidos en muchas disciplinas. Sin embargo, existen investigaciones que contradicen las tendencias mencionadas y afirman que no hay influencia del género en la citación. El objetivo de la presente revisión sistemática es analizar el panorama de artículos en inglés y en español sobre la citación, el discurso referido y la atribución, que han considerado la variable de género en el discurso académico-científico. El periodo revisado es de 1990 a 2022 y se usan las bases de datos Dialnet, Redalyc, Wiley y Google Scholar. Como resultado de la investigación se encuentra que: 1) el género influye en la citación en el discurso académico-científico; 2) faltan estudios para conocer el panorama de la citación en América Latina, Oceanía, África y Asia; 3) la mayor cantidad de estudios se han producido desde las disciplinas de bibliometría y cienciometría.
Cuerpos en venta y vidas robadas. El ejercicio de la prostitución en España
Authors: Buedo Martínez Patricia
Published: February 2024

En estos últimos años, el fenómeno de la prostitución se ha incrementado considerablemente, extendiendo sus acciones a lo largo de todo el planeta.En este progreso de expansión, el fenómeno de la globalización ha ocupado un papel fundamental contribuyendo a que el tráfico de personas víctimas de trata y de explotación sexual avance a unos niveles escalofriantes.Este trabajo tratará de analizar el ejercicio de la prostitución desde sus orígenes en nuestro país, sus distintas manifestaciones: en clubes, en pisos o habitaciones particulares, en las redes sociales, así como en las calles. Se reflejarán las consecuencias psicológicas que provocan estás prácticas en sus víctimas, así como las causas que provocaron que este fenómeno se haya perpetuado y extendido en España con tanta solidez, resistencia y rapidez, convirtiéndose en un auténtico problema de salud pública totalmente oculto o invisibilizado para la mayor parte de la población.
Seletividade alimentar e perfil sociodemográfico de crianças com transtorno do espectro autista de um movimento social de Macaé, Rio de Janeiro
Authors: Alves Beatriz Graziele Thomaz , Capelli Jane de Carlos Santana , Monteiro Luana Silva , Sperandio Naiara , Oliveira Cinara Costa de , Viviani Ana Glaucia Guariento , Jevaux Giullia Daflon , Paes Carina de Aquino
Published: February 2024

Introdução: A seletividade alimentar (SA) é caracterizada por recusa alimentar, pouco apetite e desinteresse pela comida, e é frequentemente observada em crianças com transtorno do espectro autista (TEA). Objetivo: Analisar o perfil sociodemográfico e a SA de crianças com TEA inscritas em um movimento social de Macaé, RJ. Métodos: Um estudo transversal, de base primária, foi desenvolvido entre março-junho de 2020 com todas (n=97) as crianças (2 a 9 anos 11 meses e 29 dias) com TEA e suas respectivas mães de um movimento social de Macaé. Realizou-se uma análise descritiva das variáveis por meio de distribuições de frequências absolutas e relativas e valores médios, desvio padrão [média(±DP)] e amplitude. Aplicou-se o teste qui-quadrado. Resultados: Participaram do estudo 92 (95,0%) crianças, sendo 81,5% do sexo masculino, 77,6% na fase pré-escolar, 48,1% de cor parda e com média±DP de idade de 4,52±1,3 anos para pré-escolares e 7,68±0,6 anos para escolares. Quanto a escolaridade, 83,6% dos pré-escolares e 52,0% dos escolares não eram alfabetizados. Verificou-se a renda média familiar entre 1 e 2 salários-mínimos (52,2% para pré-escolares e 56,0% para escolares). Detectaram-se 59,8% das crianças com SA, sendo mais frequente em pré-escolares (67,3%) do que em escolares (32,7%). Ambos os grupos apresentaram maior SA para cereais, leguminosas e carnes, enquanto pré-escolares também apresentaram SA frequente para macarrão (27,0%) e biscoitos (27,0%). Discussão: A SA em crianças autistas envolve aspectos neurológicos, motores, comportamentais, alimentares, dentre outros; necessitando, portanto, da intervenção multiprofissional como, por exemplo, do psicólogo, terapeuta ocupacional e nutricionista.
ADHERENCE DETERMINANT ANALYSIS OF PLHIV ON ARV (ANTIRETROVIRAL) THERAPY IN SITUBONDO DISTRICT
Authors: Wulandari Winda Cindy , Syafriadi Mei , Riyanti Rini , Sugih Utami Wiwien , Rondhianto Rondhianto
Published: February 2024

Background: Human Immunodeficiency Virus (HIV) infection causes Acquired Immune Deficiency Syndrome (AIDS), a collection of symptoms arising from the deteriorating immunity. The number of people living with HIV worldwide continues to increase year-by-year. Those infected with HIV need antiretroviral (ARV) therapy to suppress the amount of HIV in the body. Purpose: This study aimed to investigate the determinants of adherence in people living with HIV/AIDS (PLHIV) undergoing ARV therapy in Situbondo Regency. Methods: This study employed a quantitative analytic observational approach with a cross-sectional design. Data analysis involved both descriptive and multivariate analysis. The population for this study consisted of 328 individuals, from which 212 were selected as samples, all being PLHIV on ART as of April 2022, sourced from ARV treatment services in Situbondo district. Results: The research analysis was based on predisposing factors, measured using three indicators: work, knowledge, and belief in ARVs. Supporting aspects were measured by two factors: ownership of health insurance and adherence counselling. Reinforcing factors were measured using two indicators: family support and stigma in the community. Conclusion: The study concluded that predisposing and reinforcing factors significantly influenced PLHIV adherence to antiretroviral therapy. However, supporting factors did not show a significant influence on adherence in PLHIV undergoing antiretroviral therapy in the Situbondo District.
TIME TO RECOVERY FROM COVID-19 AMONG PATIENTS IN SIDOARJO REGENCY, EAST JAVA PROVINCE, INDONESIA IN 2022
Authors: Farakhin Noer , Choirul Hidajah Atik , Gumilang Retna , Setia Hadi Supaat
Published: February 2024

Background: The SARS-CoV-2 mutation in the bodies of COVID-19 patients is a critical factor for health. Notably, in October 2022, the disease recovery rate in Sidoarjo (96.05%) was lower than the national rate (97.30%). Purpose: This study aims to identify the recovery time and its influencing factors in COVID-19 patients in Sidoarjo. Methods: The life-table method was used to conduct a survival analysis on data from the NAR COVID-19 dashboard in Sidoarjo from January 3 to August 4, 2022, which involved 20,662 respondents. Age group, sex, treatment status, and testing purpose were analyzed. Results: The majority of COVID-19 patients were females (50.30%) aged 26-<46 years (46.24%). Most patients (64.74%) chose to self-isolate, and 63.34% were screened as COVID-19 positive. On average, patients recovered within seven days of diagnosis. The Wilcoxon (Gehan) statistical test yielded a p-value of less than 0.001 for all factors at a significance level of 0.05, indicating a significant difference in the survival time distribution. The age group with the shortest median recovery time was 6-<12 years at 7.03 days, while males had a median recovery time of at 7.66 days. Patients who self-isolated had a median recovery time of 7.16 days, and those who were tested for close contact purposes had a median recovery time of 7.65 days. Conclusion: The median recovery time for COVID-19 patients post-diagnosis was seven days. There was a significant difference in recovery time among the COVID-19 patients based on age group, sex, treatment status, and testing purpose.
Design and Development of a Portable Water Ionizer Based on the Internet of Things (IoT) with Battery Utilization and Portability Capability
Authors: Usman Uke Kurniawan , Mitto Antonio Abhinyano
Published: February 2024

A portable water ionizer has been successfully developed as an innovative solution to provide healthy and high-quality water conveniently while traveling. The device utilizes six 18650 lithium-ion batteries connected in series with a maximum voltage of 25.2 Volt DC and a current capacity of 1500 mAh as the main power source for the water electrolysis process. Additionally, two 8.4 Volt DC batteries are used to power the microcontroller and sensors. The total power required for the entire device is approximately 13.274 Watt, allowing the device to operate for approximately 3 hours. Portability testing was conducted through a questionnaire involving the participation of 22 respondents. The majority of respondents, 15 out of 22, stated that the device is easy to carry while traveling and demonstrates good portability. This can be attributed to its compact dimensions (17 cm x 13 cm x 37 cm) and relatively light weight (1.5 kg in dry condition and 2.5 kg in water-filled condition). Another advantage of the device is its ability to operate without a connection to household electricity, making it a practical and portable option for users to carry while traveling. The positive results of the portability testing confirm that the portable water ionizer successfully meets the desired portability standards. With its easy-to-carry design, the device can be an efficient and convenient solution for individuals who travel frequently and prioritize the quality of the water they consume.
Research on Active Repetitive Control for Tracking Lissajous Scan Trajectories with Voice Coil Motors Actuated Fast Steering Mirror
Authors: Wang Lin , Liu Shijiao , Liang Shuning , Liu Xuelian , Wang Chunyang
Published: February 2024

The performance of laser beams in tracking Lissajous scan trajectories is severely limited by beam jitter. To enhance the performance of fast steering mirror (FSM) control in tracking Lissajous scan trajectories, this paper proposed a fractional order active disturbance rejection controller (FOADRC) and verified its effectiveness in improving system scanning tracking accuracy. A dynamic mathematical model of fast steering mirror was studied and the design of parameters for the control mode of the closed-loop system was determined. A reduced order linear active disturbance rejection controller suitable for FSM systems was designed and the corresponding fractional order proportional differentiation (FOPD) controller were determined according to the mathematical model. The use of the designed controller enabled high-performance tracking of high-frequency Lissajous scanning curves (X-axis 500 Hz, Y-axis 350 Hz) and met the need for high-frequency repetitive scanning. The controller has the characteristics of simple implementation and low computational complexity and is suitable for closed-loop control applications in engineering.
Onion (Allium cepa L.) Skin Waste Valorization: Unveiling the Phenolic Profile and Biological Potential for the Creation of Bioactive Agents through Subcritical Water Extraction
Authors: Trigueros Esther , Benito-Román Óscar , Oliveira Andreia P. , Videira Romeu A. , Andrade Paula B. , Sanz M. Teresa , Beltrán Sagrario
Published: February 2024

Onion skin waste (OSW), the primary non-edible byproduct from onion processing, offers a renewable source of bioactive compounds. This study aims to valorize OSW through subcritical water extraction (SWE), aligning with circular economy and biorefinery principles. SWE was carried out at 145 °C, 50 bar and 50 min in a discontinuous reactor, producing a phenolic-rich extract (32 ± 3 mg/g), dominated by protocatechuic acid (20 ± 3 mg/g), quercetin-4´-O-glucoside (7.5 ± 0.2 mg/g), and quercetin (3.2 ± 0.6 mg/g). Additionally, it contains sugars (207 ± 20 mg sucrose-Eq/g), proteins (22.8 ± 1.6 mg BSA-Eq/g) and free amino acids (20.4 ± 1.2 mg arginine-Eq/g). Its phenolic richness determines its scavenging activity against ●NO and O2●- radicals, and its α-glucosidase and aldose-reductase inhibition without affecting α-amylase. Notably, the extract demonstrates significant α-glucosidase inhibition (IC50 = 76 ± 4 µg/mL), surpassing acarbose (IC50 = 129.5 ± 1.0 µg/mL), in both pure enzyme and cell culture tests without showing cytotoxicity on AGS, HepG2 and Caco-2 human cell lines. The extract’s bioactivity and nutritional content make it suitable for developing antioxidant and antidiabetic nutraceutical/food components, highlighting the SWE potential for OSW valorization without using organic solvents.