bluuebunny/crossref_metadata_2025 huggingface dataset:
Imbalance of fetal growth factor levels in congenital heart disease pathology: a systematic review to investigate therapeutic potential
Authors: Ghandi Yazdan , Shahvari Samira Zakeri , Ahmadian Negar Poor , Soltani Mahbod , Musavi Seyed Amir Hossein , Satarzadeh Mohammad
Published: June 2024

Background
Vascular endothelial growth factor (VEGF) is a factor that is responsible for cell proliferation, vascular endothelial cell growth, and angiogenesis. Changes in the level of this factor are associated with the pathology of structural disorders such as CHD. This systematic study assessed previous studies to determine the therapeutic potential of VEGF in congenital heart disorders.
Method
This systematic review was written based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria, and the principle of nonbias was respected. All the articles from 2014–2024 were extracted from the Web of Science, PubMed and Scopus databases. We investigated the role of VEGF in the pathology of cardiovascular structural disorders, the therapeutic and diagnostic effects of VEGF and related factors that are influenced by this factor.
Results
The studies were assessed based on PRISMA search steps, and 22 were included in our study. Any disturbance in the production and function of VEGF is known as a genetic disorder in TOF. VEGF caused abnormal elongation of the heart tubes, as well as disproportionate growth of cardiovascular tissue just before full formation. An increase in HIF with increasing VEGF function precedes fetal heart development. HIF also mediates endothelial formation through eNOS. HIF in children with CCHD and ACHD was significantly greater than that in the control group, and its value was greater in complex CHD children than in the other groups. EGFR, iNOS and ET-1 were more abundant in ACHD than in ACHD, and their levels were positively correlated with HIF.
Conclusion
An increase in the levels of VEGF and HIF before the completion of CHD pathology is the main cause of CHD pathology, and after the completion of CHD pathology, these factors help in the regeneration of heart tissue. The regulation of VEGF and HIF levels during the fetal period is highly important for the diagnosis and treatment of CHD.
CXCL7 plays a crucial role in facilitating extramedullary invasion and osteolytic damage in multiple myeloma
Authors: Liu Peng , Wang Yue , Lan Tianwei , Zhou Chi
Published: June 2024

The primary distinction between multiple myeloma (MM) and its precursor conditions lies in the deterioration of the biological behavior of tumor cells. In MM, a type of mature B-cell tumor, chemokines may serve as pivotal regulatory genes. Through exploration of GEO database and single-cell RNA-seq data from our laboratory, we have identified chemokines CXCL7 as a potential key regulator of the cellular biological behavior in MM. Subsets of MM cells with high CXCL7 exhibit heightened malignant potential. Elevated CXCL7 is associated with extramedullary invasion and pathological fractures in patients. In vitro, CXCL7 promoted the proliferation, invasion and migration of MM cells. Leveraging the homing ability of plasma cell, we established a mouse xenograft tumor model through vein injection of a CXCL7-overexpressing cell line. We found that MM cells with elevated CXCL7 exhibited enhanced engraftment in bone marrow, induced extramedullary lesions and increased susceptibility to leg fractures. Through exploration of intracellular signaling pathways and subsequent experiments, we observed that CXCL7 can modulate the biological behavior of MM cells by activating the IL-2-STAT5 pathway in the absence of exogenous IL-2. Our findings provide new insights into understanding the pathogenesis mechanisms underlying MM, suggesting that targeting CXCL7 may offer promising therapeutic opportunities.
The Preparation of a novel moisture-curing silicone conformal coating
Authors: Pan Zhaoqun , Zhong Min , Lin Liangwei
Published: June 2024

In this research, high molecular weight hydroxyl-terminated polydimethylsiloxane (PDMS-OH) was successfully synthesized through a hydroxyl condensation reaction. The optimal reaction conditions included a temperature of 110°C, a reaction time of 4 hours, and a catalyst TMAH amount of 0.08 phr. The structure of PDMS-OH was characterized using nuclear magnetic resonance (1H-NMR) spectroscopy. Subsequently, the PDMS-OH was end-capped with methyl orthosilicate (TMOS) to produce PDMS-TMOS, with a capping agent to hydroxyl group molar ratio of 2:1. The structural analysis of PDMS-TMOS was conducted using Fourier transform infrared spectroscopy (FT-IR) and 1H-NMR. The surface drying time for the moisture-curing coating of PDMS-TMOS was found to be 2 hours at room temperature and 25 minutes at 80 ℃, respectively. The addition of MQ resins to the conformal coatings resulted in a tensile strength of 0.0742 MPa and an elongation at break of 212.7% for the formed film. The coating offers advantages such as a straightforward synthesis process, cost-effectiveness, and high reproducibility, thereby potentially broadening its industrial applications.
Eculizumab as first line treatment for patients with severe presentation of Complement Factor H antibodies mediated Hemolytic Uremic Syndrome
Authors: Coccia Paula Alejandra , Alconcher Laura Fernanda , Ferraris Veronica , Lucarelli Lucas Ivan , Grillo Maria Agostina , Arias Andrea , Saurit Mariana , Ratto Viviana Marcela , Raddavero Caludia Andrea , Santos Celia Dos , Lucero Analía Sanchez
Published: June 2024

Background: Complement Factor H (CFH) antibodies mediated Hemolytic Uremic Syndrome (HUS) has varying prevalence globally. Plasmapheresis and Immunosuppressive drugs are the standard treatment. Recently, Eculizumab has been reported as an effective alternative. The aim of this study is to report four children with CFH antibodies mediated HUS managed with Eculizumab plus immunosuppression as first line therapy.Methods: A retrospective chart review was conducted for children aged ≤ 18 years old with complement-mediated HUS in two referral centers. Patients with CFH antibodies mediated HUS treated with Eculizumab as first-line therapy were included.Results: Four children (aged 6–11 years old) were included. Dialysis was necessary in three patients. Eculizumab was administered 5–23 days after onset. None of them received plasmapheresis. Prednisone and mycophenolate mofetil were added after receiving positive CFH antibody results. Hematological signs and kidney function improved after the second Eculizumab dose. Eculizumab was discontinued in three patients after six months. One patient required rituximab due to persistent high CFH antibody titers, discontinuation of Eculizumab occurred after 15 months without recurrence. No treatment-related complications were observed. During a mean 12-month follow-up (range 6–24 months), no relapses were recorded and all patients ended with normal GFR.Conclusion Our data suggest that a short course of 6 months of C5 inhibitor might be sufficient to reverse TMA symptoms and improve kidney function in severe patients with CFH antibody mediated HUS. Simultaneously, adding immunosuppressive agents might reduce the risk of relapse and allow cessation of C5 inhibition in a shorter period of time.
Evaluation of alternative prognostic thresholds for SP142 and 22C3 immunohistochemical PD-L1 expression in triple-negative breast cancer: results from a population-based cohort
Authors: Sigurjonsdottir Gudbjörg , De Marchi Tommaso , Ehinger Anna , Hartman Johan , Ullén Susann , Leandersson Karin , Bosch Ana , Staaf Johan , Killander Fredrika , Niméus Emma
Published: June 2024

Background
Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regards to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs) and TNBC molecular subtypes.
Material & Methods
We evaluated PD-L1 on a tissue microarray with the SP142 (immune cell (IC) score) and the 22C3 (combined positive score; CPS) IHC assays and evaluated abundance of TILs in a population-based cohort of 237 early-stage TNBC patients. Survival analysis was performed and RNA sequencing data employed for molecular profiling.
Results
As expected, PD-L1 positivity (IC ≥1% and/or CPS ≥1) was significantly associated with better prognosis compared to zero PD-L1 expression. Importantly however, also patients with intermediate expression (IC >0%, <1%; CPS >0, <1) showed a trend towards improved outcome. Tumors with intermediate PD-L1 IHC expression also had intermediate PD-L1 (CD274) gene expression (mRNA). Patients that were both low in TILs (<30%) and PD-L1 (IC <1%; CPS <1), tended to have the poorest prognosis.
PD-L1 positive tumors clustered significantly more often as Immunomodulatory-high and Basal-Like 1-high TNBC molecular subtypes and were enriched in immune response and cell cycle/proliferation signaling pathways. PD-L1-zero tumors on the other hand were enriched in cell growth, differentiation and metastatic potential pathways and clustered more prevalently as Luminal-Androgen-Receptor-high and Mesenchymal-high. PD-L1-intermediate tumors categorized with neither PD-L1-positive nor PD-L1-zero tumors on the hierarchical clustering level, consigning them as a unique subgroup.
Conclusion
With both SP142 and 22C3, we identified an intermediate IHC PD-L1 group within TNBCs that was supported on the molecular level. Any PD-L1 IHC expression, even though it is <1, tended to have positive prognostic impact. We suggest that the generally accepted threshold of PD-L1 IHC positivity in TNBC should be investigated further.
Trial Registration The Swedish Cancerome Analysis Network – Breast (SCAN-B) study was retrospectively registered 2nd Dec 2014 at ClinicalTrials.gov; ID NCT02306096.
A rare cause of echogenic kidneys with oligohydramnios in the fetus: report of two different cases
Authors: Phetthong Tim , Achaloetvaranon Krit , Diawtipsukon Sanpon
Published: June 2024

Background
Prenatal ultrasound findings of fetal bilateral echogenic kidneys accompanied by oligohydramnios can be highly stressful for both pregnant women and physicians. The diversity of underlying causes makes it challenging to confirm a prenatal diagnosis, predict postnatal outcomes, and counsel regarding recurrence risks in future pregnancies.
Case Presentation
We report two cases of abnormal fetal echogenic kidneys with oligohydramnios detected in the early third trimester. Autosomal recessive polycystic kidney disease (ARPKD), a rare genetic syndrome, was initially suspected in both cases. However, postnatal diagnoses differed: the first case was confirmed as glomerulocystic kidney disease (GCKD) through renal pathology, while the second case was diagnosed as ARPKD with a compound heterozygous likely pathogenic PKHD1 mutation.
Conclusion
Prenatal diagnosis of fetal echogenic kidneys with oligohydramnios should prioritize accurate diagnosis. Given the differences in the clinical spectrum, GCKD should be considered a differential diagnosis for this condition, particularly ARPKD. This study highlights the importance and benefits of postnatal renal pathology and molecular diagnosis for precise diagnosis and effective counseling.
Workplace Accommodations and the Labour Force Status of Persons with Disabilities
Authors: Schimmele Christoph , Jeon Sung-Hee , Arim Rubab
Published: June 2024

Purpose
The aim of the study is to examine the role of unmet needs for workplace accommodations (WPA) in the labour force status of persons with disabilities (PWD) aged 25–64 years.
Methods
The study used data from the 2017 Canadian Survey on Disability and multinomial logistic regressions to estimate the predicted probabilities of employment, unemployment, detachment from the labour force, and retirement. Product terms were used to examine if the association between unmet needs for WPA and these employment outcomes depended on severity of disability and age group.
Results
The findings show that the probability of employment was far lower for PWD with unmet needs for WPA than it was for their counterparts without unmet needs, after controlling for disability-related and sociodemographic characteristics. While having more severe disabilities associated with a lower employment rate, this occurred entirely in the context of unmet needs for WPA, as there was no difference between persons with milder and more severe disabilities without unmet needs. Unmet needs for WPA had age-specific consequences and were associated with a higher probability of unemployment and detachment from the labour force among PWDs aged 25–34 years and a higher probability of retirement among PWD aged 55–64 years.
Conclusion
Unmet needs for WPA are a barrier to the employment chances of many PWD and eliminating these needs could increase their inclusion in the labour force.
Denticle rows on larval appendages in twelve species of Phytoseiidae (Parasitiformes: Mesostigmata)
Authors: Ren Fang-Xu , Wei Xin-Ju , Ma Min , Fan Qing-Hai
Published: June 2024

The presence of denticles on appendages such as the palpi and legs is rarely documented in phytoseiid mite larvae. To address this gap, we studied twelve species across six genera of Phytoseiidae: Amblydromalus limonicus, Amblyseius herbicolus, Amblyseius orientalis, Amblyseius taiguensis, Euseius utilis, Neoseiulus benjamini, Neoseiulus californicus, Neoseiulus setarius, Neoseiulus womersleyi, Neoseiulus zwoelferi, Phytoseiulus persimilis and Phytoseius hongkongensis. We identified and described the denticles on the palp, basis capitulum, and specific leg segments of these species, discussing their functional significance.
Simultaneous Functionality of Tamm Plasmon Mode-Based Refractive Index Sensor Across Multiple Photonic Bandgaps
Authors: Sharma Anup Kumar , Srivast Amod Kumar , Maji Partha Sona , Kumar Samir
Published: June 2024

In this work, a refractive index sensor based on Tamm plasmons mode is proposed, capable of concurrent functionality across diverse photonic bandgaps. The proposed sensor structure consists of an analyte cavity sandwiched between a one-dimensional photonic crystal of SiO2/TiO2 and a thin metal film. Tamm resonances are observed within different photonic bandgaps. The functioning principle of this optical sensor relies on altering the refractive index of the analyte, resulting in a shift in either the transmission or reflection spectrum. The study reveals that the resonance wavelength demonstrates a linear increase with the rise in the analyte's refractive index. The study reveals that simultaneous utilization of Tamm Plasmon sensors across multiple bandgaps enables multiplexed sensing, where we can detect multiple analytes or parameters in parallel. Tamm resonance-based sensors, notable for their main advantage of prism-free coupling, offer a compelling alternative to other optical sensors like surface plasmon resonance-based sensors.
Active-Bromide and Surfactant Synergy for Enhanced Microfouling Control
Authors: Shukla Sudhir K , Rao T. Subba , Mohan T. V. Krishna
Published: June 2024

Biofilms are structured microbial communities encased in a matrix of self-produced extracellular polymeric substance (EPS) and pose significant challenges in various industrial cooling systems. A nuclear power plant uses a biocide active-bromide for control of biological growth in its condenser cooling system. This study is aimed to evaluate the anti-bacterial and anti-biofilm efficacy of active-bromide against planktonic and biofilm-forming bacteria that are commonly encountered in seawater cooling systems. The results demonstrated that active-bromide at the concentration used at the power plant (1 ppm) exhibited minimal killing activity against Pseudomonas aeruginosa planktonic cells. Biofilm inhibition assays using Staphylococcus aureus and P. aeruginosa also revealed limited efficacy at 1 ppm concentration. However, the addition of a surfactant, Triton-X 100, in combination with active-bromide displayed a synergistic effect, leading to significant biofilm dispersal of pre-formed P. aeruginosa biofilms. These findings suggest that active bromide alone may be insufficient for microfouling control in the seawater-based condenser cooling system of the power plant. The inclusion of a compatible surfactant that dislodged established biofilms (microfouling) has enhanced the effectiveness of active bromide action.
Effects of Remdesivir on liver enzymes, oxidative stress and Liver histopathology in rats
Authors: Abbasi Mehran Mesgari , Darbani Roya , Rabet Oldouz , Ghorbanihaghjo Amir , Rashtchizadeh Nadereh , Raeisi Sina , Khordadmehr Monireh
Published: June 2024

Background & Aims: Remdesivir (REM) has been widely used to treat subjects affected by COVID-19 due to its broad-spectrum activity. The aim was to assess the REM effect on liver histopathology, enzymes, and alterations in oxidative stress markers.Methods Forty-eight Wistar rats were separated into eight groups as follows: Group A (Control) received normal saline intraperitoneally (IP) for 10 days; Group B (Low-dose REM) received REM (2.8 mg/kg for the first day and 1.4 mg/kg for days 2 to 10, IP); Group C (High-dose REM) received REM (8.5 mg/kg IP for the first 17 days and days 2 to 10); Group D (High-dose REM + DEX (Dexamethasone) + HEP (Heparin) received DEX (7 mg/kg intramuscularly for 10 days) and HEP (333 IU/kg subcutaneously on the first day and 250 IU/kg subcutaneously every 12 hours from day 2 to day 10); Group E (High-dose REM + DEX); Group F (High-dose REM + HEP); Group G (DEX); Group H (HEP). For statistical analysis, non-parametric tests (Kruskal-Wallis H and Mann-Whitney U) were used for pathological lesions (semi-quantitative data) between the different groups, and a p < 0.05 was considered significant.Results There were mild to severe pathological changes in the treated groups, including cell swelling, vascular congestion. Also, the D and G groups showed similar pathological lesions, which were more severe than in other treated groups with a significant difference (p < 0.05).Conclusions Remdesivir causes hepatic toxicity and alterations in oxidative stress markers, and therefore monitoring is required during treatment.
Firewall Log Classification: Leveraging Feature Selection and Stacking Ensemble
Authors: Monfared Amir Hussein Ataei , Borna Keivan
Published: June 2024

Firewall logs can provide valuable information about attempted security breaches and attacks. By classifying these logs, security teams can more easily identify patterns and potential threats, allowing them to take proactive measures to protect their systems. This paper presents a thorough analysis of the various features found in firewall log data. It focuses on selecting the most crucial features using feature selection techniques. The recommended feature sets are then assessed using stacking ensemble XGBoost to demonstrate their suitability. In order to compare the effectiveness of different feature selection techniques, we evaluated at least one member from each technique family using the proposed method. The experimental findings indicate that when Feature Shuffle Random Forest is used in conjunction with the proposed approach, the resulting model is the most accurate, achieving a performance evaluation metric of 99.93\%, signifying exceptional accuracy.
Role of Triply Periodic Minimal Surface Ti6Al4V ELI alloy lattices fabricated by L-PBF method on cell behavior and inflammatory response
Authors: Srimaneep Viritpon , Trachoo Vorapat , Phothichailert Suphalak , Srithanya Supreda Suphanantachat , Mahanonda Rangsini , Norbert Heil , Khrueaduangkham Suppakrit , Promoppatum Patcharapit , Osathanon Thanaphum
Published: June 2024

Triple Periodic Minimal Surface lattices have been introduced to dental and medical devices. Numerous designs of these porous structures have been proposed, but the biomechanical effects of the different topographic lattices are not fully understood. So, this study aimed to examine the cell and inflammatory responses to different lattice designs, including strut-based and surface-based lattices. Human osteoblasts, human umbilical vein endothelial cells, and monocytes were used to evaluate cell proliferation, osteogenic differentiation, and inflammatory response on lattices after surface treatment strategies. Post-surface treatment of chemical etching, besides improving the surface roughness by removing some adhered metal powder, also modulated the surface energy. Lattice design had no significant impact on cell proliferation, but higher cell proliferation was found in post-surface treated lattices, regardless of topographic design. For angiogenesis, there was no difference in the release of pro-angiogenic growth factors between topographic designs or post-surface treatment groups. Moreover, lattices with the post-surface treatment were prone to have lower inflammation phenotype when compared to as-printed lattice, though not in a significant manner. This study suggests that different topographic lattice designs may not have a major impact on bone ingrowth, but post-surface treatment and surface properties of lattice could suppress a macrophage-induced inflammatory response.
Puerarin ameliorates apoptosis and inflammation induced by kidney stones through the PI3K/AKT pathway: Network pharmacology and experimental validation
Authors: Xu Yuexian , Liang Hu , Mao Xike , Song Zhenyu , Shen Xudong , Ge Defeng , Chen Yang , Hou Bingbing , Hao Zongyao
Published: June 2024

Puerarin(PUE), an isoflavonoid extracted from Pueraria root, has anti-apoptotic effects. The objective of this research is to examine the impact of PUE on renal apoptosis and inflammation resulting from renal calculi and to elucidate its mechanism.The approach of network pharmacology and molecular docking was employed to discover potential targets and pathways of PUE. An animal model of calcium oxalate crystal deposition by intraperitoneal injection of glyoxylate and a model of COM-induced human renal tubular epithelial cells (HK2) were used to investigate the pharmacological mechanisms of PUE against apoptosis and inflammation. We used hematoxylin-eosin (H&E) and Periodic Acid-Schiff staining (PAS) to assess the effect of PUE on crystal deposition and damage. The mechanism of PUE was elucidated and validated using Western blotting, histology, and immunohistochemical staining.Network pharmacology findings indicated that the PI3K/AKT pathway plays a crucial role in PUE. We experimentally demonstrate that PUE alleviated COM-induced changes in apoptotic proteins, increased inflammatory indicators and changes in oxidative stress-related indicators in HK2 cells by activating the PI3K/AKT pathway, reduced serum creatinine and urea nitrogen levels in mice caused by CaOx, alleviated crystal deposition and damage, and alleviated apoptosis, oxidative stress and inflammation.Puerarin attenuates renal apoptosis and inflammation caused by kidney stones through the PI3K/AKT pathway.
GESTIÓN ADMINISTRATIVA Y RENTABILIDAD EN LA MICROEMPRESA “TODO CELL” DEL CANTÓN MONTECRISTI
Authors: Ponce Álvarez Cruz Verónica , Muñoz Moreira Gema Natalia
Published: June 2024

La gestión administrativa eficaz y la rentabilidad son elementos fundamentales para el éxito de cualquier organización. En este contexto, la microempresa “Todo Cell”, ubicada en el cantón Montecristi, enfrenta la falta de herramientas de análisis adecuadas, la percepción mixta sobre la calidad de la gestión administrativa y la necesidad de mejorar la eficiencia en áreas clave como la facturación y el control de inventario. Por lo tanto, el objetivo de esta investigación fue determinar la influencia de la gestión administrativa en la rentabilidad de la microempresa. La metodología utilizada fue a través de la entrevista al gerente y las encuestas dirigidas a los trabajadores de “Todo Cell”, utilizando preguntas estructuradas para recopilar información sobre diversos aspectos de la gestión administrativa y la rentabilidad. Entre los resultados relevantes se identificaron desafíos significativos en la gestión administrativa, con un 54% de los encuestados señalando la facturación y cobranza como el principal problema, seguido por el control de inventario con un 23%.
FORMACION Y CAPACITACION Y EL DESEMPEÑO LABORAL DE LOS SERVIDORES DEL GAD MUNICIPAL PAJAN
Authors: Calle García Aldrin Jefferson , Tigua Victores Gabriela Lilibeth
Published: June 2024

En el Gobierno Autónomo Descentralizado Municipal Paján, la formación y capacitación de los servidores públicos son aspectos fundamentales para garantizar su efectividad y el cumplimiento de los objetivos organizacionales. Sin embargo, a pesar de los esfuerzos existen desafíos que incluyen la falta de conocimiento sobre las normativas que rigen estos programas, la percepción variada sobre su efectividad y la necesidad de una evaluación más rigurosa de su impacto. Por lo tanto, el objetivo principal de este estudio es determinar la incidencia de la formación y capacitación en el desempeño laboral de los servidores del GAD Municipal Paján del año 2022. Para alcanzar este objetivo, se empleó una metodología mixta que incluyó las encuestas y la entrevista con los servidores públicos del GAD, además se utilizaron técnicas cualitativas y cuantitativas para recopilar datos sobre la percepción de los empleados. Los resultados revelan que el 75% de los encuestados participaron en programas de formación y capacitación proporcionados por el GAD Municipal Paján, siendo el 18% de ellos quienes afirmaron que mejoraron su desempeño laboral como resultado de estos programas. Sin embargo, un 38% reportó que no experimentaron mejoras significativas. En conclusión, este estudio destaca las medidas para mejorar la comunicación y la evaluación de los programas, así como para adaptarlos a las necesidades específicas de los empleados. Al abordar estas áreas de mejora, el GAD Municipal Paján puede mejorar significativamente la efectividad de sus programas de formación y capacitación, lo que contribuirá al desarrollo profesional y al éxito organizacional.
GESTIÓN FINANCIERA Y SU INCIDENCIA EN EL PROCESO CONTABLE DEL GAD PARROQUIAL DE SALANGO
Authors: Acuña Pincay Daniela Yanelli , Soledispa Reyes Sara Geoconda
Published: June 2024

El sector público se encuentra atravesando un proceso de cambio constante año a año, en especial los gobiernos parroquiales, donde se observa ciertas insuficiencias en la gestión financiera al no aplicar correctamente los procedimientos de control interno de la Contraloría General del Estado. De este modo, este estudio tiene como objetivo examinar la gestión financiera y su incidencia en el proceso contable del Gobierno Autónomo Descentralizado Parroquial de Salango, donde se desarrollaron aspectos y conceptualizaciones en el proceso investigativo, donde se aplicó la metodología bajo un enfoque cuantitativo con un diseño no experimental, los métodos aplicados son el inductivo, deductivo y cuantitativo que permiten realizar un estudio e elucidación de los resultados y el método bibliográfico que son bases para el desarrollo del artículo científico. Se utilizo en la investigación la técnica de encuesta para la obtención de información. La población con la que se trabajo fue los 13 funcionarios del GAD parroquial donde se determino el manejo de la gestión financiera de la institución.
Current Evidence on Molecular Mechanisms of Andrographolide in Cancer
Authors: Attri Dharam Chand , Dhyani Praveen , Trivedi Vijay Laxmi , Sharma Eshita , Ibrayeva Manshuk , Jantwal Arvind , Sati Priyanka , Calina Daniela , Sharifi-Rad Javad
Published: June 2024

Cancer, a diverse group of diseases characterized by abnormal cell growth
and the potential to spread throughout the body, accounts for approximately 10 million
deaths globally each year. Current cancer therapies, including chemotherapy, radiation,
and various pharmacological treatments, present several challenges and potential side effects.
It is important to differentiate these conventional methods, which often involve
synthetic drugs, from adjuvant therapies that might be used in conjunction. As a result,
there is an increasing interest in alternative therapies, particularly in agents derived from
natural sources for cancer treatment. Secondary metabolites have shown promise in promoting
the development of new clinical drugs with various anti-cancer mechanisms.
This review focuses on the anti-cancer potential of the novel metabolite Andrographolide,
extracted mainly from Andrographis paniculata. The chemopreventive properties
and the ability to inhibit various signaling pathways across different types of cancers
without side effects posit Andrographolide as a promising natural antitumour agent.
The review identified that Andrographolide inhibits multiple signaling pathways, contributing
to its anti-proliferative, anti-metastatic, and apoptotic effects in various cancers.
The compound's natural origin and lack of adverse side effects make it particularly
attractive as a therapeutic agent. However, further detailed studies are needed to fully understand
its specific mechanisms and potential clinical applications. Andrographolide
presents a compelling option as a natural anticancer agent with the potential to overcome
some limitations of traditional cancer treatments. Its broad spectrum of anti-cancer
activities and absence of side effects highlight its therapeutic potential. The review highlights
that continued research and clinical studies are important for confirming the effectiveness
and safety of Andrographolide in human use, alongside optimizing dosage and
delivery techniques.
Sevoflurane and Propofol Co-affect the Development of Colorectal Cancer by Regulating TM2D1
Authors: Lu Yan , Li Ling , Piao Zongfang , Tan Xinmin , Su Rui
Published: June 2024

Aims:

Sevoflurane and propofol are the most commonly used anesthetics in surgery.
In this study, we aim to explore and clarify the function of sevoflurane and propofol in colorectal
cancer.

Methods:

Cell counting kit-8, colony formation, western blot, and transwell assays were performed
to determine cell proliferation, apoptosis, ferroptosis, invasion, and migration. We performed
overexpression experiments to detect the underlying molecular mechanism of sevoflurane
and propofol. The genes related to epithelial-mesenchymal transition were measured by
western blot.

Results:

We discovered that sevoflurane and propofol co-treatment exerted more anti-tumor activities
than just sevoflurane or propofol treatment in colorectal cancer cells in vitro. Mechanistically,
our data showed that sevoflurane and propofol-induced apoptosis and ferroptosis and inhibited
cell proliferation, invasion, and migration. Additionally, TM2D1 was considered a target
of sevoflurane and propofol, and TM2D1 overexpression reversed the effect of sevoflurane and
propofol on colorectal cancer cell biology behaviors.

Conclusion:

Our results showed a novel anti-tumor mechanism of sevoflurane and propofol in
colorectal cancer cells, and TM2D1 might be an underlying therapeutic target for treating colorectal
cancer patients.

other:

Our results showed novel anti-tumor mechanism of sevoflurane and propofol in colorectal cancer cells, and TM2D1 might be an underlying therapeutic target for treatment of colorectal cancer patients.
Effects of Oxidative Stress on Serum Metabolism in Acute Pancreatitis Rats Based on Untargeted Metabolomics
Authors: Chen Jinfeng , Meng Nuo , Lei Yu , Feng Yong , Li Yurong , Tang Xiping
Published: June 2024

Objectives:

Acute pancreatitis(AP) is a common digestive tract disease, often accompanied
by severe metabolic disorders, but there are no specific markers and treatment methods,
and the potential metabolic pathways behind it remain to be explored.

Methods:

Establish mild acute pancreatitis and severe acute pancreatitis models in rats and intervene
with antioxidant NAC. Analyze serum oxidative stress indicators and pathological changes
in pancreatic tissue. In addition, non-targeted metabolomics analysis of serum differential metabolites
between groups was conducted based on the LC/MS system.

Results:

The pathological score of the model group rats increased, and the levels of oxidative
stress factors ROS and MDA significantly increased, while the activity of the antioxidant enzyme
SOD decreased. After NAC intervention, oxidative stress damage in rats was alleviated.
Non-targeted metabolomics experiments suggest significant differences in serum metabolic profiles
among different groups of rats.

Conclusion:

Metabolomics results show that the obtained differential metabolites are expected to
become serum biomarkers for AP.

result:

In the untargeted metabolomics test, we found that there were obvious differences in serum metabolic profiles of rats. The MAP model group was compared with the NC group, we selected 7 significant differential metabolites, including PC, Tuftsin, etc. The comparison of the MAP + NAC intervention group with the MAP group yielded a total of five significantly differential metabolites, including 20-Deoxynarasin, VPGPR Enterostatin and 12-Ketoporrigenin et al. Compared with the SO group, 23 metabolites with significant differences were screened out in SAP group. The comparison of SAP + NAC intervention group with SAP model group selected 10 significantly different metabolites, including lipids (PC, PE), Physalolactone B, etc.. These metabolites are involved in complex pathophysiological processes such as oxidative stress and inflammation, involving various metabolic pathways such as glycerophospholipid metabolism, arachidonic acid metabolism, and pentose and glucuronate interconversions.
Rheum khorasanicum Decreases Migration and Induces Apoptosis in the MDA-MB-231 Breast Cancer Cell Line
Authors: Mehrabani Mitra , Miri Zahra , Juybari Kobra Bahrampour , Najafi Rezvan , Goki Maryamossadat Mirtajaddini , Aminizadeh Najmeh , Nematollahi Mohammad Hadi , Vasei Saeede , Mehrabani Mehrnaz , Amirkhosravi Arian
Published: June 2024

Background:

Rheum khorasanicum is a medicinal plant that belongs to the Polygonaceae
family. This family is well-known for its anticancer activities.

Objective:

Due to the limited studies on the anticancer activity of R. khorasanicum, the present study
aimed to evaluate the apoptotic effect of this medicinal plant on MDA-MB-231 cells as a model for
an aggressive triple-negative breast cancer that has a lower treatment option.

Methods:

R. khorasanicum root was collected in April, 2021 from Neyshabur, Iran, and its hydroalcoholic
extract was prepared using the maceration method. The High-Performance Thin-Layer
Chromatography (HPTLC) assay was used to determine the main ingredients of the extract. The
viability and apoptosis of the cells were evaluated by WST-1 and the annexin-V/PI dual staining
assay, respectively. The scratch assay was used to assess the migratory potential of cancer cells, and
the Western blotting test was employed for determining the expression of Bcl-2, Bax, cleaved caspase-
3, cleaved caspase-7, and procaspase-7 proteins involved in the apoptotic pathway.

Results:

The yield of extract from R. khorasanicum root was 56.8 ± 11.1%. The HPTLC analysis
indicated that emodin, gallic acid, and epigallocatechin were pharmacologically active compounds
isolated from the hydroalcoholic extract of R. khorasanicum root. The extract showed a significant
toxic effect on MDA-MB-231 cells up to 60 μg/mL concentration. R. khorasanicum root extracts
also inhibited the migratory potential of MDA-MB-231 at concentrations ≥ 60 μg/mL. The plant root
extract at concentrations of 60 and 100 μg/mL significantly increased the Bax/Bcl-2 ratio cleaved
caspase-3, cleaved caspase-7/ procaspase-7 protein levels compared to the nontreated cells.

Conclusion:

Our findings demonstrated that the hydroalcoholic extract of R. khorasanicum efficiently
triggered the apoptosis of MDA-MB-231 cells as a suitable model for aggressive triple-negative
breast cancer, possibly by decreasing their migratory potential and stimulating the apoptotic signaling
pathway.
Variations in the Solar Modulation Parameter Over the Last 9.5 Thousand
Years and the Tilt of the Geomagnetic Dipole
Authors: Vasiliev Sergey S. , Dergachev Valentin A.
Published: June 2024

Background:

Calculations of the solar modulation parameter (Φ) over the past millennia
typically use the relationship between the production rate of cosmogenic isotopes, the earth's
dipole moment, and the magnitude of Φ. The cosmogenic isotopes 14C and 10Be are typically used
in these studies. When studying solar modulation, the cyclic change in dipole tilt is usually not
taken into account, which affects estimates of past solar activity.

Methods:

Tree rings are a reliable basis for obtaining a radiocarbon time scale (IntCal13). However,
determining the concentration of 14C in tree rings is a difficult and controversial task. The
time scale derived from the 10Be production rate simulation (GICC05) is less reliable. Nevertheless,
there is a way to combine the accuracy of the radiocarbon time scale with the reliability of
estimates of the 10Be production rate. This method is the synchronization of the radiocarbon and
beryllium-10 series.
We have selected the most relevant methods for calculating the solar modulation parameter Φ for
the Holocene. When calculating Φ, 10Be data synchronized with 14C data were used. The latest
data on the earth's dipole moment were considered. Empirical Mode Decomposition (EMD) was
used in the analysis of Φ.

Results:

It has been shown that the first two decomposition modes are oscillating components
with periods of 710 and 208 years, the amplitudes of which increase with time, reaching a maximum
of 2500 BP. From contemplation, it follows that the 710-year oscillations are apparently
caused by fluctuations in the tilt of the earth's dipole. After excluding the EMD component associated
with the 710-year cyclicity, a corrected series was obtained for the solar modulation parameter,
free from the influence of changes in the tilt of the magnetic dipole.

Conclusion:

The rate of formation of cosmogenic radionuclides depends on the intensity of penetration
of Galactic Cosmic Rays (GCRs) into the earth's atmosphere. Before reaching earth, GCRs
must cross the heliosphere, where they are exposed to solar modulation. Adequate consideration
of solar modulation parameters is important for the correct interpretation of the rate of production
of cosmogenic isotopes and solar activity.
The Construction of Chinese Securities Fraud Rules
Authors: Pei Zhu
Published: June 2024

Building an effective and fair legal system is one of the ultimate goals of China’s capital market construction. To protect minority investors, changes has been made in recent years, especially rules about securities fraud. Though China constantly reform its securities regulation system, whether is it a perfect solution to transplant the regulation in US securities market remains unknown. This article is to critically examine China’s securities fraud regulation, both from the perspective of practice and theory. It is argued that the impact of these changes has the common goal and that they will make profound basis on capital market.
Estimating Coherent Contributions to the Error Profile Using Cycle Error Reconstruction
Authors: Carignan-Dugas Arnaud , Ranu Shashank Kumar , Dreher Patrick
Published: June 2024

Mitigation and calibration schemes are central to maximize the computational reach of today's Noisy Intermediate Scale Quantum (NISQ) hardware, but these schemes are often specialized to exclusively address either coherent or decoherent error sources. Quantifying the two types of errors hence constitutes a desirable feature when it comes to benchmarking error suppression tools. In this paper, we present a scalable and cycle-centric methodology for obtaining a detailed estimate of the coherent contribution to the error profile of a hard computing cycle. The protocol that we suggest is based on Cycle Error Reconstruction (CER), also known as K-body Noise Reconstruction (KNR). This protocol is similar to Cycle Benchmarking (CB) in that it provides a cycle-centric diagnostic based on Pauli fidelity estimation \cite{erhard2019characterizing}. We introduce an additional hyper-parameter in CER by allowing the hard cycles to be folded multiple times before being subject to Pauli twirling. Performing CER for different values of our added hyper-parameter allows estimating the coherent error contributions through a generalization of the fidelity decay formula. We confirm the accuracy of our method through numerical simulations on a quantum simulator, and perform proof-of-concept experiments on three IBM chips, namely ibmq_guadalupe, ibmq_manila, and ibmq_montreal. In all three experiments, we measure substantial coherent errors biased in Z.
Mandatory corporate social responsibility by Indian companies: A case of isomorphism due to social need or regulation?
Authors: Kumar Chitresh , Ganguly Anirban
Published: June 2024

The study proposes a framework to establish the isomorphic nature of corporate social responsibility (CSR) expenditure for Indian companies. Isomorphism in NIFTY-50 companies of India was analysed using the Herfindahl-Hirschman Index (HHI) and Shannon-Weiner Index (SWI). This was followed by a qualitative study of six organisations as a case study and an analysis of interviews with 29 managers of different organisations involved in CSR practices. NIFTY-50 companies were found to be isomorphic. A study of six group companies and the analysis of interviews of 29 CSR business managers, found that isomorphism in Indian companies can be termed as long-term social legitimacy-seeking behaviour. A company’s relationship with society shifts from seeking internal and external legitimacy to having a symbiotic relationship with society. In the long-term, the company uses its CSR to seek legitimacy at all levels (from the grass-root level community to the highest level of state actors). The study was done for the pre-COVID-19 financial years starting 2014–2015.
CHARACTER DEPICTION WITH BEHAVIORAL PROCESS IN 'NOUVELLES VERTES' SHORT STORIES
Authors: Prasetyo Gilang Tegar , Sajarwa
Published: June 2024

This study aims to describe the forms of clauses with behavioral processes that explain characterizations in the short story anthology Nouvelles Vertes, and the characterization techniques realized by the behavioral processes. This research uses a descriptive approach with qualitative method. The data of this research are clauses that explain characterization with behavioral process in the short stories of Nouvelles Vertes anthology. This research uses the theory of Systemic Functional Linguistics by Halliday and Matthiesen (2014) and characterization technique by Nurgiyantoro (2018). The results show that there are three types of behavioral processes used to explain characterization, i.e. verbal, mental, and physical. The characterization techniques realized with behavioral processes are in the form of character reaction techniques and thoughts and feelings techniques. The tendency to use behavioral processes with character reaction techniques shows that each event in the short story directly affects the character's behavior in terms of speech, actions, and feelings.
Novel use of the rectus abdominus muscle flap for vaginal reconstruction in complex obstetric fistula repair: a case series
Authors: T. Patel , R. Brown , Chipungu Ennet , Breen Michael , J. Draganchuk , P. Nampandeni , Yemane Awol , Wilkinson Jeffrey
Published: June 2024

Globally, obstetric fistula is a tragic outcome following obstructed
labor. Failure of complex repairs and post-operative incontinence are
common. We describe an innovative surgical technique incorporating the
rectus abdominis muscle flap at the time of fistula repair. We report
outcomes from six patients at the Fistula Care Center in Lilongwe,
Malawi in October 2023. At three months following discharge, five
patients (80.0%) were continent; one patient was unable to follow-up
but was continent at a one-month phone follow-up. There were no major
complications. The rectus abdominis muscle flap may be considered in
challenging obstetric fistula repairs.
Latent Diffusion Model for Quantitative Precipitation Estimation and Forecast at km Scale
Authors: Li Weidong , Pan Baoxiang , Li Tiejian , nai Congyi , Li Zhaoxi , Lu Bo , Duan Qingyun , Pan Ming
Published: June 2024

Numerical weather prediction models often struggle to accurately
simulate high-resolution precipitation processes, due to resolution
limits and difficulties in representing convection and cloud
microphysics. Data-driven methods often offer more accurate
approximation of these unresolved processes by learning from
high-fidelity referential data. Yet, existing approaches fail to yield
fine-resolution, spatially coherent, reliable ensemble
simulations/predictions, particularly for high-impact extreme events. To
address these limitations, we develop a latent diffusion modeling (LDM)
framework for quantitative precipitation estimation and forecast. The
LDM leverages low-resolution (25 km) circulation and topographic
information to estimate precipitation at a 4 km resolution. The latent
diffusion model (LDM) learns the probability distribution of
precipitation patterns by first compressing high-resolution spatial data
into a compact, Quasi-Gaussian latent space. It then gradually refines
estimates through a deep neural network parameterized reverse diffusion
process, effectively capturing complex precipitation dynamics and
delivering superior ensemble predictions. This approach enables LDMs to
outperform traditional deep learning models like convolutional neural
nets and generative adversarial neural nets, particularly for extreme
events, while avoiding issues such as mode collapse, blurring artifacts,
or underestimation of extremes. Compared to the dynamical method (WRF
and GFS), the LDM offers significant performance gains, particularly for
extreme precipitation events, improving over 30% in root mean squared
error and over 40% in critical success index. For the extreme
precipitation (> 300 mm/d) in California on October 25,
2021, LDM can provide effective forecasting up to 7 days in advance,
forced by circulation prediction from a data-driven weather forecasting
model.
Antecedents and Consequences of Materialistic Values: A Systematic Literature Review
Authors:   PhD Scholar, Lahore University of Management Sciences (LUMS), Hamza Nawaz Butt Muhammad , Abdur Rahman Malik Muhammad ,   Assistant Professor, Lahore University of Management Sciences (LUMS).
Published: June 2024

By applying systematic literature review technique, this paper focuses on the existing research on materialistic values. Although materialistic values have widely been discussed in the literature, this stream of literature lacks in the context of work setting. To the best of our knowledge, reviews focusing on materialistic values haven’t been conducted in the organizational context. Initial search returned a total of 1,191 articles, out of which 209 articles were thoroughly analyzed based on their relevance to the topic. After studying the antecedents, correlates and consequences of materialistic values within literature, the paper identifies three important theoretical and empirical gaps in the literature. Firstly, the literature on materialistic values is vaguely scattered and needs consolidation. Secondly, most of research on materialistic values is a-theoretical in nature. Thirdly, literature on materialistic values lacks within the organizational setting. To fill these gaps, this paper consolidates the literature into theoretical frameworks and proposes theoretical foundations for the future researchers. In addition, the paper points towards some fertile areas largely missing in existing literature. In the end, some managerial implications and limitations of the study are discussed.