bluuebunny/crossref_metadata_2025 huggingface dataset:
Consistency of Eating Rate, Oral Processing Behaviours and Energy Intake across Meals
Authors: McCrickerd Keri , Forde Ciaran
Published: August 2017

Faster eating has been identified as a risk factor for obesity and the current study tested whether eating rate is consistent within an individual and linked to energy intake across multiple meals. Measures of ad libitum intake, eating rate, and oral processing at the same or similar test meal were recorded on four non-consecutive days for 146 participants (117 male, 29 female) recruited across four separate studies. All the meals were video recorded, and oral processing behaviours were derived through behavioural coding. Eating behaviours showed good to excellent consistency across the meals (intra-class correlation coefficients > 0.76, p < 0.001) and participants who ate faster took larger bites (β ≥ 0.39, p < 0.001) and consistently consumed more energy, independent of meal palatability, sex, body composition and reported appetite (β ≥ 0.17, p ≤ 0.025). Importantly, eating faster at one meal predicted faster eating and increased energy intake at subsequent meals (β > 0.20, p < 0.05). Faster eating is relatively consistent within individuals and is predictive of faster eating and increased energy intake at subsequent similar meals consumed in a laboratory context, independent of individual differences in body composition.
Resveratrol in Hepatitis C Patients Treated with Pegylated-Interferon-α-2b and Ribavirin Reduces Sleep Disturbance
Authors: Pennisi Manuela , Bertino Gaetano , Gagliano Caterina , Malaguarnera Michele , Bella Rita , Borzì Antonio , Madeddu Roberto , Drago Filippo , Malaguarnera Giulia
Published: August 2017

Background: Hepatitis C virus infection and interferon treatment have shown to be risk factors for sleep disorder health-related quality of life. Aim: To determine whether the effects of resveratrol on sleep disorders were associated with different tests in subjects with chronic hepatitis C treated with Peg-IFN-α and RBV. Patients and Methods: In this prospective, randomized, placebo controlled, double blind clinical trial, 30 subjects (Group A) with chronic hepatitis received Pegylated-Interferon-α2b (1.5 mg/kg per week), Ribavirin and placebo (N-acetylcysteine 600 mg and lactoferrin 23.6 g), while 30 subjects (Group B) received the same dosage of Pegylated-Interferon-α2b, Ribavirin and association of N-acetylcysteine 600 mg, lactoferrin 23.6 g and Resveratrol 19.8 mg for 12 months. All subjects underwent laboratory exams and questionnaires to evaluate mood and sleep disorders (General Health Questionnaire (GHQ), Profile of Mood States (POMS), Pittsburgh Sleep Quality Inventory (PSQI), Epworth Sleepiness Scale (ESS)). Results: The comparison between Group A and Group B showed significant differences after six months in C-reactive protein (p < 0.0001); after 12 months in aspartate aminotransferase (AST) (p < 0.0001) Viremia (p < 0.0001), HAI (p < 0.0012) and C-reactive protein (p < 0.0001); and at follow up in AST (p < 0.0001), Viremia (p < 0.0026) and C-reactive protein (p < 0.0001). Significant differences were observed after 12 month and follow-up in General Health Questionnaire, after 1, 6, 12 and follow-up in Profile of Mood States, after 6, 12, follow-up in Pittsburgh Sleep Quality Inventory and Epworth Sleepiness Scale. Conclusions: Supplementation with Resveratrol decreased General Health Questionnaire score and reduced sleep disorders in patients treated with Peg–IFN-α and RBV.
Vitamin D Status of Residents in Taiyuan, China and Influencing Factors
Authors: Yan Xiaoning , Thomson Jasmine , Zhao Ruibao , Zhu Ruifang , Wang Zhaolin , Zhang Na , Coad Jane
Published: August 2017

High prevalence of vitamin D deficiency has been reported worldwide. Residents of Taiyuan, China, were predicted to be at high risk of vitamin D deficiency due to its high latitude, heavy air pollution, and cultural sun avoidance. This study investigated the vitamin D status of office workers, and explored the potential determinants of capillary 25-hydroxyvitamin D (25(OH)D) concentration as well as the relationship between 25(OH)D and metabolic syndrome. Two hundred participants, aged 20 to 80 years, were recruited. Capillary dried blood spot (DBS) 25(OH)D was measured; together with anthropometric (height, weight, and waist circumference), biochemical (serum lipid profile and fasting glucose) measures and a lifestyle questionnaire. Thirty-four percent of participants had 25(OH)D concentrations below 30 nmol/L, indicating deficient vitamin D status. Women’s 25(OH)D (median; 32.7 nmol/L (upper and lower quartile; 25.8, 43.8)) was significantly lower than men (44.0 nmol/L (32.3, 55.4)) (p < 0.01). Female gender, higher fasting glucose, and increased smoking (p < 0.05) were negatively associated with 25(OH)D concentration. However, there was no association found between metabolic syndrome (MetS) and 25(OH)D concentration and no significant difference in vitamin D status between men or women with MetS compared to healthy individuals. Vitamin D deficiency was common in urban residents of Taiyuan in winter and more so in women than men.
Choline Supplementation Normalizes Fetal Adiposity and Reduces Lipogenic Gene Expression in a Mouse Model of Maternal Obesity
Authors: Jack-Roberts Chauntelle , Joselit Yaelle , Nanobashvili Khatia , Bretter Rachel , Malysheva Olga , Caudill Marie , Saxena Anjana , Axen Kathleen , Gomaa Ahmed , Jiang Xinyin
Published: August 2017

Maternal obesity increases fetal adiposity which may adversely affect metabolic health of the offspring. Choline regulates lipid metabolism and thus may influence adiposity. This study investigates the effect of maternal choline supplementation on fetal adiposity in a mouse model of maternal obesity. C57BL/6J mice were fed either a high-fat (HF) diet or a control (NF) diet and received either 25 mM choline supplemented (CS) or control untreated (CO) drinking water for 6 weeks before timed-mating and throughout gestation. At embryonic day 17.5, HF feeding led to higher (p < 0.05) percent total body fat in fetuses from the HFCO group, while the choline supplemented HFCS group did not show significant difference versus the NFCO group. Similarly, HF feeding led to higher (p < 0.05) hepatic triglyceride accumulation in the HFCO but not the HFCS fetuses. mRNA levels of lipogenic genes such as Acc1, Fads1, and Elovl5, as well as the transcription factor Srebp1c that favors lipogenesis were downregulated (p < 0.05) by maternal choline supplementation in the HFCS group, which may serve as a mechanism to reduce fat accumulation in the fetal liver during maternal HF feeding. In summary, maternal choline supplementation improves indices of fetal adiposity in obese dams at late gestation.
Applying a Consumer Behavior Lens to Salt Reduction Initiatives
Authors: Regan Áine , Kent Monique , Raats Monique , McConnon Áine , Wall Patrick , Dubois Lise
Published: August 2017

Reformulation of food products to reduce salt content has been a central strategy for achieving population level salt reduction. In this paper, we reflect on current reformulation strategies and consider how consumer behavior determines the ultimate success of these strategies. We consider the merits of adopting a ‘health by stealth’, silent approach to reformulation compared to implementing a communications strategy which draws on labeling initiatives in tandem with reformulation efforts. We end this paper by calling for a multi-actor approach which utilizes co-design, participatory tools to facilitate the involvement of all stakeholders, including, and especially, consumers, in making decisions around how best to achieve population-level salt reduction.
The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables
Authors: Dacosta Christopher , Bao Yongping
Published: August 2017

Colorectal cancer is an increasingly significant cause of mortality whose risk is linked to diet and inversely correlated with cruciferous vegetable consumption. This is likely to be partly attributable to the isothiocyanates derived from eating these vegetables, such as sulforaphane, which is extensively characterised for cytoprotective and tumour-suppressing activities. However, its bioactivities are likely to extend in complexity beyond those currently known; further insight into these bioactivities could aid the development of sulforaphane-based chemopreventive or chemotherapeutic strategies. Evidence suggests that sulforaphane modulates the expression of microRNAs, many of which are known to regulate genes involved at various stages of colorectal carcinogenesis. Based upon existing knowledge, there exist many plausible mechanisms by which sulforaphane may regulate microRNAs. Thus, there is a strong case for the further investigation of the roles of microRNAs in the anti-cancer effects of sulforaphane. There are several different types of approach to the wide-scale profiling of microRNA differential expression. Array-based methods may involve the use of RT-qPCR or complementary hybridisation probe chips, and tend to be relatively fast and economical. Cloning and deep sequencing approaches are more expensive and labour-intensive, but are worth considering where viable, for their greater sensitivity and ability to detect novel microRNAs.
Eating Disorders and Disordered Eating Symptoms in Adolescents with Type 1 Diabetes
Authors: Toni Giada , Berioli Maria , Cerquiglini Laura , Ceccarini Giulia , Grohmann Ursula , Principi Nicola , Esposito Susanna
Published: August 2017

Eating problems in adolescents with type 1 diabetes (T1D) can be divided into two groups. The first includes the diagnosed eating disorders (EDs), i.e., diseases specifically identified by defined signs and symptoms for which a degree of severity has been established, such as anorexia nervosa, bulimia nervosa, binge-eating disorder, pica, and rumination. The second is the group of disordered eating symptoms (DES), which include behaviors such as dieting for weight loss, binge eating, self-induced vomiting, excessive exercise, and laxative or diuretic use; these behaviors cannot be categorized as complete diseases, and, although apparently mild, they must be closely evaluated because they can evolve into true EDs. In this review, present knowledge about the clinical relevance of EDs and DES and the possible preventive and therapeutic measures used to reduce their impact on the course of T1D will be discussed. As adolescents with diabetes are at higher risk of eating disturbances and consequently for higher rates of disease complications, care providers should pay attention to clinical warning signs that raise suspicion of disturbed eating to refer these patients early to an expert in nutrition and mental health disorders. To ensure the best care for adolescents with T1D, diabetes teams should be multidisciplinary and include a pediatric diabetologist, a skilled nurse, a dietician, and a psychologist.
Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity
Authors: Herranz-López María , Olivares-Vicente Mariló , Encinar José , Barrajón-Catalán Enrique , Segura-Carretero Antonio , Joven Jorge , Micol Vicente
Published: August 2017

Improper diet can alter gene expression by breaking the energy balance equation and changing metabolic and oxidative stress biomarkers, which can result in the development of obesity-related metabolic disorders. The pleiotropic effects of dietary plant polyphenols are capable of counteracting by modulating different key molecular targets at the cell, as well as through epigenetic modifications. Hibiscus sabdariffa (HS)-derived polyphenols are known to ameliorate various obesity-related conditions. Recent evidence leads to propose the complex nature of the underlying mechanism of action. This multi-targeted mechanism includes the regulation of energy metabolism, oxidative stress and inflammatory pathways, transcription factors, hormones and peptides, digestive enzymes, as well as epigenetic modifications. This article reviews the accumulated evidence on the multiple anti-obesity effects of HS polyphenols in cell and animal models, as well as in humans, and its putative molecular targets. In silico studies reveal the capacity of several HS polyphenols to act as putative ligands for different digestive and metabolic enzymes, which may also deserve further attention. Therefore, a global approach including integrated and networked omics techniques, virtual screening and epigenetic analysis is necessary to fully understand the molecular mechanisms of HS polyphenols and metabolites involved, as well as their possible implications in the design of safe and effective polyphenolic formulations for obesity.
Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern
Authors: Haroun-Díaz Elisa , Azofra Julián , González-Mancebo Eloína , De las Heras Manuel , Pastor-Vargas Carlos , Esteban Vanesa , Villalba Mayte , Díaz-Perales Araceli , Cuesta-Herranz Javier
Published: August 2017

Introduction: Different clinical and molecular patterns of food allergy have been reported in different areas of the world. The aim of the study is to evaluate differences in allergen patterns among nut-allergic patients in two different areas of Spain. Material and methods: A total of 77 patients with nut allergy from two different regions of Spain (Madrid and Asturias) were evaluated. Results: Hazelnut, peanut, and walnut were the three most frequent nuts eliciting allergy in both regions, but in a different order. Patients from Madrid experienced systemic reactions more often than patients from Asturias (73.5% Madrid vs. 50.0%, p < 0.05). The percentage of sensitizations to LTP (Lipid Transfer Protein) was higher than Bet v 1 (p < 0.05) in the Madrid area. The percentage of sensitizations in Asturias area was similar to LTP than Bet v 1 (Pru p 3 46.4%, Bet v 1 42.9%, ns). Bet v 1 was the predominant allergen involved among hazelnut-allergic patients (56.2%), while LTP was more common in peanut-allergic patients (61.5%). Conclusion: Walnut, hazelnut, and peanut were the most frequent nuts eliciting allergy in Spain. Despite this, important differences in molecular pattern were appreciated not only between both regions, but also among nut-allergic patients in Asturias. The different molecular pattern was linked to the frequency of systemic symptoms.
Adapting the Healthy Eating Index 2010 for the Canadian Population: Evidence from the Canadian Community Health Survey
Authors: Jessri Mahsa , Ng Alena , L’Abbé Mary
Published: August 2017

The Healthy Eating Index (HEI) is a diet quality index shown to be associated with reduced chronic disease risk. Older versions of the HEI have been adapted for Canadian populations; however, no Canadian modification of the Healthy Eating Index-2010 (HEI-2010) has been made. The aims of this study were: (a) to develop a Canadian adaptation of the HEI-2010 (i.e., Healthy Eating Index-Canada 2010 (HEI-C 2010)) by adapting the recommendations of the HEI-2010 to Canada’s Food Guide (CFG) 2007; (b) to evaluate the validity and reliability of the HEI-C 2010; and (c) to examine relationships between HEI-C 2010 scores with diet quality and the likelihood of being obese. Data from 12,805 participants (≥18 years) were obtained from the Canadian Community Health Survey Cycle 2.2. Weighted multivariate logistic regression was used to test the association between compliance to the HEI-C 2010 recommendations and the likelihood of being obese, adjusting for errors in self-reported dietary data. The total mean error-corrected HEI-C 2010 score was 50.85 ± 0.35 out of 100. Principal component analysis confirmed multidimensionality of the HEI-C 2010, while Cronbach’s α = 0.78 demonstrated internal reliability. Participants in the fourth quartile of the HEI-C 2010 with the healthiest diets were less likely to consume refined grains and empty calories and more likely to consume beneficial nutrients and foods (p-trend < 0.0001). Lower adherence to the index recommendations was inversely associated with the likelihood of being obese; this association strengthened after correction for measurement error (Odds Ratio: 1.41; 95% Confidence Interval: 1.17–1.71). Closer adherence to Canada’s Food Guide 2007 assessed through the HEI-C 2010 was associated with improved diet quality and reductions in the likelihood of obesity when energy intake and measurement errors were taken into account. Consideration of energy requirements and energy density in future updates of Canada’s Food Guide are important and necessary to ensure broader application and usability of dietary quality indexes developed based on this national nutrition guideline.
Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway
Authors: Amawi Haneen , Ashby Charles , Samuel Temesgen , Peraman Ramalingam , Tiwari Amit
Published: August 2017

The epithelial-to-mesenchymal transition (EMT) has received significant interest as a novel target in cancer prevention, metastasis, and resistance. The conversion of cells from an epithelial, adhesive state to a mesenchymal, motile state is one of the key events in the development of cancer metastasis. Polyphenols have been reported to be efficacious in the prevention of cancer and reversing cancer progression. Recently, the antimetastatic efficacy of polyphenols has been reported, thereby expanding the potential use of these compounds beyond chemoprevention. Polyphenols may affect EMT pathways, which are involved in cancer metastasis; for example, polyphenols increase the levels of epithelial markers, but downregulate the mesenchymal markers. Polyphenols also alter the level of expression and functionality of important proteins in other signaling pathways that control cellular mesenchymal characteristics. However, the specific proteins that are directly affected by polyphenols in these signaling pathways remain to be elucidated. The aim of this review is to analyze current evidence regarding the role of polyphenols in attenuating EMT-mediated cancer progression and metastasis. We also discuss the role of the most important polyphenol subclasses and members of the polyphenols in reversing metastasis and targeting EMT. Finally, limitations and future directions to improve our understanding in this field are discussed.
Efficient Transdermal Delivery of Alendronate, a Nitrogen-Containing Bisphosphonate, Using Tip-Loaded Self-Dissolving Microneedle Arrays for the Treatment of Osteoporosis
Authors: Katsumi Hidemasa , Tanaka Yutaro , Hitomi Kaori , Liu Shu , Quan Ying-shu , Kamiyama Fumio , Sakane Toshiyasu , Yamamoto Akira
Published: August 2017

To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)–MN). We observed micron-scale pores in rat skin just after application of ALN(TIP)–MN, indicating that transdermal pathways for ALN were created by MN. ALN was rapidly released from the tip of MNs as observed in an in vitro release study. The tip portions of MNs completely dissolved in the rat skin within 5 min after application in vivo. After application of ALN(TIP)–MN in mice, the plasma concentration of ALN rapidly increased, and the bioavailability of ALN was approximately 96%. In addition, the decrease in growth plate was effectively suppressed by this efficient delivery of ALN in a rat model of osteoporosis. Furthermore, no skin irritation was observed after application of ALN(TIP)–MN and subcutaneous injection of ALN, while mild skin irritation was induced by whole-ALN-loaded MN (ALN–MN)—in which ALN is contained in the whole of the micron-scale needles fabricated from hyaluronic acid—and intradermal injection of ALN. These findings indicate that ALN(TIP)–MN is a promising transdermal formulation for the treatment of osteoporosis without skin irritation.
Current Status and Future Suggestions for Improving the Pharm. D Curriculum towards Clinical Pharmacy Practice in Pakistan
Authors: Malhi Saima , Raza Hassan , Ajmal Kiran , Shamim Sumbul , Ata Saniya , Farooq Salman , Sharib Syed , Muntaha Sidrat-ul
Published: August 2017

Objectives & Background: Good curriculum is reflected as the backbone for standard universities to develop competitive professionals having great potential. Pharmacy education in Pakistan has gone through the same developmental stages as in other countries, but is still striving for improvement. In the present study, we want (i) to know the opinion on whether the current pharmacy curriculum requires any improvement in order to meet the training needs of pharmacy professionals regarding clinical knowledge and pharmacy practice; and (ii) to present some humble suggestions to decision-making authorities in order to improve it with respect to patient-focused programs (PFP). Methods: The study was conducted in two sessions. In first session, a questionnaire was distributed to pharmacy students of eight public/private sector universities of Karachi (N = 354) offering Pharm. D degrees. The second session dealt with the pharmacy teachers, deans, and practicing pharmacists in health care facilities (who are in any ways also related to academia), in order to take their opinions on and suggestions for the development of a better Pharm. D curriculum (N = 135). Results: Our results showed that 75.2% of respondents agree that the Pharm. D curriculum does not meet the international standards of practice, and 88.4% of respondents support the addition of more clinical aspects than industrial ones, as Pharm. D could be both clinically and industrially oriented, according to the needs of the Pakistani people. Furthermore, 80.2% of respondents are of the view that an apprenticeship should be included in last two years, while 88.4% demand a ‘paid residency program’ to facilitate the hospital, clinical and compounding areas of pharmacy. In addition, we also received a number of verbal suggestions for improving the Pharm. D curriculum being followed in Pakistan. Discussion & Conclusions: We conclude that our Pharm. D curriculum needs additions in terms of clinical practice by providing residencies and electives in health care settings. Accordingly, the need for a clinically oriented curriculum is highlighted in Pakistan, keeping in mind the continuing importance of the industrial viewpoint. Various studies have criticized the pharmacy curriculum in Pakistan in the past. Conversely, we suggest some changes in the curriculum, as change is always needed for a better tomorrow.
Biodegradation Studies of Novel Fluorinated Di-Vinyl Urethane Monomers and Interaction of Biological Elements with Their Polymerized Films
Authors: Delaviz Yasaman , Yang Meilin , Santerre J.
Published: August 2017

The monomeric components of resin composites in dental restorative materials are susceptible to hydrolysis in the oral cavity. The main objective of this study was to assess the bio-stability of fluorinated urethane dimethacrylates and determine the nature of fluoro-chemistry interactions with protein and bacterial adhesion (both sources of hydrolytic activity) onto cured resin. Degradation studies were performed in the presence of either albumin (in a mildly alkaline pH) or cholesterol esterase (CE). The surface chemistry of the polymers was assessed by water contact angle measurements, pre- and post- incubation with albumin. Adhesion of Streptococcus mutans to cured resin was investigated. The fluorinated monomers were more stable against degradation when compared to the commercial monomer bisphenol A-diglycidyl methacrylate (BisGMA). While fluorinated monomers showed hydrolytic stability with respect to CE, all fluorinated monomers underwent some degree of degradation with albumin. The fluoro-chemistry did not reduce protein and/or bacterial adhesion onto the surface, however post incubation with albumin, the fluorinated surfaces still presented hydrophobic character as determined by the high contact angle values ranging from 79° to 86°. These monomers could potentially be used to increase the hydrophobicity of polymeric composites and provide a means to moderate esterolytic degradation associated with the monomeric component of the polymers within the oral cavity.
Pulp Fines—Characterization, Sheet Formation, and Comparison to Microfibrillated Cellulose
Authors: Fischer Wolfgang , Mayr Melanie , Spirk Stefan , Reishofer David , Jagiello Lukas , Schmiedt Romana , Colson Jerome , Zankel Armin , Bauer Wolfgang
Published: August 2017

In the pulp and paper industry different types of pulp or fiber fines are generated during the pulping (primary fines, mechanical fines), and/or the refining process (secondary fines). Besides fibers, these cellulosic microparticles are a further component of the paper network. Fines, which are defined as the fraction of pulp that is able to pass through a mesh screen or a perforated plate having a hole diameter of 76 μm, are known to influence the properties of the final paper product. To better understand the effect and properties of this material, fines have to be separated from the pulp and investigated as an independent material. In the present study, fines are isolated from the pulp fraction by means of a laboratory pressure screen. To allow for further processing, the solids content of the produced fines suspension was increased using dissolved air flotation. Morphological properties of different types of fines and other cellulosic microparticles, such as microfibrillated celluloses (MFC) are determined and compared to each other. Furthermore, handsheets are prepared from these materials and properties, such as apparent density, contact angle, modulus of elasticity, and strain are measured giving similar results for the analyzed types of fines in comparison to the tested MFC grades. The analysis of the properties of fiber fines contributes on the one hand to a better understanding of how these materials influences the final paper products, and on the other hand, helps in identifying other potential applications of this material.
Constraining Polymers into β-Turns: Miscibility and Phase Segregation Effects in Lipid Monolayers
Authors: Deike Stefanie , Malke Marlen , Lechner Bob-Dan , Binder Wolfgang H.
Published: August 2017

Abstract: Investigation of model biomembranes and their interactions with natural or synthetic macromolecules are of great interest to design membrane systems with specific properties such as drug-delivery. Here we study the behavior of amphiphilic β-turn mimetic polymer conjugates at the air–water interface and their interactions with lipid model membranes. For this endeavor we synthesized two different types of conjugates containing either hydrophobic polyisobutylene (PIB, Mn = 5000 g·mol−1) or helical poly(n-hexyl isocyanate) (PHIC, Mn = 4000 g·mol−1), both polymers being immiscible, whereas polyisobutylene as a hydrophobic polymer can incorporate into lipid membranes. The conjugates were investigated using Langmuir-film techniques coupled with epifluorescence microscopy and AFM (Atomic Force Microscopy), in addition to their phase behavior in mixed lipid/polymer membranes composed of DPPC (dipalmitoyl-sn-glycero-3-phosphocholine). It was found that the DPPC monolayers are strongly disturbed by the presence of the polymer conjugates and that domain formation of the polymer conjugates occurs at high surface pressures (π > 30 mN·m−1).
Bacterial Nanocellulose from Side-Streams of Kombucha Beverages Production: Preparation and Physical-Chemical Properties
Authors: Dima Stefan-Ovidiu , Panaitescu Denis-Mihaela , Orban Csongor , Ghiurea Marius , Doncea Sanda-Maria , Fierascu Radu , Nistor Cristina , Alexandrescu Elvira , Nicolae Cristian-Andi , Trică Bogdan , Moraru Angela , Oancea Florin
Published: August 2017

We focused on preparing cellulose nanofibrils by purification, separation, and mechanical treatment of Kombucha membranes (KM) resulted as secondary product from beverage production by fermentation of tea broth with symbiotic culture of bacteria and yeast (SCOBY). We purified KM using two alkaline solutions, 1 and 4 M NaOH, which afterwards were subjected to various mechanical treatments. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS), X-ray diffraction (XRD), X-ray fluorescence (XRF), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA) were employed to evaluate the purification degree, the size and aspect of cellulose fibrils after each treatment step, the physical-chemical properties of intermediary and final product, and for comparison with micro-crystalline cellulose from wooden sources. We determined that 1 M NaOH solution leads to approx. 85% purification, while a higher concentration assures almost 97% impurities removal. XRD analysis evidenced an increase in crystallinity from 37% to 87% after purification, the characteristic diffractograms of Iα and Iβ cellulose allomorphs, and a further decrease in crystallinity to 46% after microfluidization, fact correlated with a drastically decrease in fibrils’ size. FTIR analysis evidenced the appearance of new chain ends by specific transmission bands at 2941 and 2843cm−1.
Mechanical Properties of Composite Hydrogels of Alginate and Cellulose Nanofibrils
Authors: Aarstad Olav , Heggset Ellinor , Pedersen Ina , Bjørnøy Sindre , Syverud Kristin , Strand Berit
Published: August 2017

Alginate and cellulose nanofibrils (CNF) are attractive materials for tissue engineering and regenerative medicine. CNF gels are generally weaker and more brittle than alginate gels, while alginate gels are elastic and have high rupture strength. Alginate properties depend on their guluronan and mannuronan content and their sequence pattern and molecular weight. Likewise, CNF exists in various qualities with properties depending on, e.g., morphology and charge density. In this study combinations of three types of alginate with different composition and two types of CNF with different charge and degree of fibrillation have been studied. Assessments of the composite gels revealed that attractive properties like high rupture strength, high compressibility, high gel rigidity at small deformations (Young’s modulus), and low syneresis was obtained compared to the pure gels. The effects varied with relative amounts of CNF and alginate, alginate type, and CNF quality. The largest effects were obtained by combining oxidized CNF with the alginates. Hence, by combining the two biopolymers in composite gels, it is possible to tune the rupture strength, Young’s modulus, syneresis, as well as stability in physiological saline solution, which are all important properties for the use as scaffolds in tissue engineering.
Increased X-ray Visualization of Shape Memory Polymer Foams by Chemical Incorporation of Iodine Motifs
Authors: Nash Landon , Browning Monroe Mary , Ding Yong-Hong , Ezell Kendal , Boyle Anthony , Kadirvel Ramanathan , Kallmes David , Maitland Duncan
Published: August 2017

Shape memory polymers can be programmed into a secondary geometry and recovered to their primary geometry with the application of a controlled stimulus. Porous shape memory polymer foam scaffolds that respond to body temperature show particular promise for embolic medical applications. A limitation for the minimally invasive delivery of these materials is an inherent lack of X-ray contrast. In this work, a triiodobenzene containing a monomer was incorporated into a shape memory polymer foam material system to chemically impart X-ray visibility and increase material toughness. Composition and process changes enabled further control over material density and thermomechanical properties. The proposed material system demonstrates a wide range of tailorable functional properties for the design of embolic medical devices, including X-ray visibility, expansion rate, and porosity. Enhanced visualization of these materials can improve the acute performance of medical devices used to treat vascular malformations, and the material porosity provides a healing scaffold for durable occlusion.
A Long-Short Term Memory Recurrent Neural Network Based Reinforcement Learning Controller for Office Heating Ventilation and Air Conditioning Systems
Authors: Wang Yuan , Velswamy Kirubakaran , Huang Biao
Published: August 2017

Energy optimization in buildings by controlling the Heating Ventilation and Air Conditioning (HVAC) system is being researched extensively. In this paper, a model-free actor-critic Reinforcement Learning (RL) controller is designed using a variant of artificial recurrent neural networks called Long-Short-Term Memory (LSTM) networks. Optimization of thermal comfort alongside energy consumption is the goal in tuning this RL controller. The test platform, our office space, is designed using SketchUp. Using OpenStudio, the HVAC system is installed in the office. The control schemes (ideal thermal comfort, a traditional control and the RL control) are implemented in MATLAB. Using the Building Control Virtual Test Bed (BCVTB), the control of the thermostat schedule during each sample time is implemented for the office in EnergyPlus alongside local weather data. Results from training and validation indicate that the RL controller improves thermal comfort by an average of 15% and energy efficiency by an average of 2.5% as compared to other strategies mentioned.
Perspectives on Resource Recovery from Bio-Based Production Processes: From Concept to Implementation
Authors: Udugama Isuru , Mansouri Seyed , Mitic Aleksandar , Flores-Alsina Xavier , Gernaey Krist
Published: August 2017

Recovering valuable compounds from waste streams of bio-based production processes is in line with the circular economy paradigm, and is achievable by implementing “simple-to-use” and well-established process separation technologies. Such solutions are acceptable from industrial, economic and environmental points of view, implying relatively easy future implementation on pilot- and full-scale levels in the bio-based industry. Reviewing such technologies is therefore the focus here. Considerations about technology readiness level (TRL) and Net Present Value (NPV) are included in the review, since TRL and NPV contribute significantly to the techno-economic evaluation of future and promising process solutions. Based on the present review, a qualitative guideline for resource recovery from bio-based production processes is proposed. Finally, future approaches and perspectives toward identification and implementation of suitable resource recovery units for bio-based production processes are discussed.
A Microsomal Proteomics View of H2O2- and ABA-Dependent Responses
Authors: Alqurashi May , Thomas Ludivine , Gehring Chris , Marondedze Claudius
Published: August 2017

The plant hormone abscisic acid (ABA) modulates a number of plant developmental processes and responses to stress. In planta, ABA has been shown to induce reactive oxygen species (ROS) production through the action of plasma membrane-associated nicotinamide adenine dinucleotide phosphate (NADPH)-oxidases. Although quantitative proteomics studies have been performed to identify ABA- or hydrogen peroxide (H2O2)-dependent proteins, little is known about the ABA- and H2O2-dependent microsomal proteome changes. Here, we examined the effect of 50 µM of either H2O2 or ABA on the Arabidopsis microsomal proteome using tandem mass spectrometry and identified 86 specifically H2O2-dependent, and 52 specifically ABA-dependent proteins that are differentially expressed. We observed differential accumulation of proteins involved in the tricarboxylic acid (TCA) cycle notably in response to H2O2. Of these, aconitase 3 responded to both H2O2 and ABA. Additionally, over 30 proteins linked to RNA biology responded significantly to both treatments. Gene ontology categories such as ‘response to stress’ and ‘transport’ were enriched, suggesting that H2O2 or ABA directly and/or indirectly cause complex and partly overlapping cellular responses. Data are available via ProteomeXchange with identifier PXD006513.
Science’s Big Problem, Reincarnation’s Big Potential, and Buddhists’ Profound Embarrassment
Authors: Christopher Ted
Published: August 2017

Scientific materialism is the largely unquestioned basis for modern science’s understanding of life. It also holds enormous sway beyond science and thus has increasingly marginalized religious perspectives. Yet it is easy to find behavioral phenomena from the accepted literature that seriously challenge materialism. A number of these phenomena are very suggestive of reincarnation. The larger test for science’s paradigm, though, as well as for any potential general import from reincarnation, is the DNA (or genetics)-based model of heredity. If that conception-beget, DNA (deoxyribonucleic acid)-carried model can be confirmed at the individual level then in a very substantial way we would be confirmed as material-only creatures. In particular, can behavioral genetics and personal genomics confirm their DNA-based presumptions? During the last decade enormous efforts have been made to find the DNA origins for a number of health and behavioral tendencies. These efforts have been an “absolutely beyond belief” failure and it is here that the scientific vision faces its biggest challenge. The common pre-modern reincarnation understanding, on the other hand, fits well on a number of specific conundrums and offers a broad coherence across this unfolding missing heritability mystery. For people trying to make sense of a religious perspective or simply questioning materialism, you should be looking at the missing heritability problem.
Depression and Spiritual Distress in Adult Palliative Patients: A Cross-Sectional Study
Authors: Velosa Teresa , Caldeira Sílvia , Capelas Manuel
Published: August 2017

Palliative care patients have been associated with a high probability of having depression and spiritual distress. However, there is a gap in research about the clinical indicators that can promote an effective differential diagnosis of depression and spiritual distress. This study aimed to identify the prevalence and the clinical indicators of depression and spiritual distress in palliative patients in primary care. An observational and cross-sectional study was conducted in 2016 in a Portuguese primary care unit. From a General Practitioners patients’ file of 1457 adult patients, a sample of 30 palliative patients was recruited throughout two steps: (1) selection of patients with chronic disease criteria; (2) selection of patients with Prognostic Indicator Guidance criteria. Exclusion criteria included cognitive impairment and psychotic disorders. Participants completed the self-assessment Hospital Anxiety and Depression Scale (HADS) and Functional Assessment of Chronic Illness Therapy—Spiritual Well-Being Scale (FACIT-Sp12) scales, which were sealed in opaque envelopes. Clinical data collection used semi-structured interviews for the diagnosis of depression and spiritual distress. The prevalence of depression was 23% (n = 7), while the prevalence of spiritual distress was 23% (n = 7). Four patients (13%) fulfilled both the depression and the spiritual distress criteria. Depression and spiritual distress seem to be both linked to the spiritual dimensions of the human being, but seem to differ in the dimensions of suffering and pharmacologic treatment.
Specular Reflection Effects Elimination in Terrestrial Laser Scanning Intensity Data Using Phong Model
Authors: Tan Kai , Cheng Xiaojun
Published: August 2017

The intensity value recorded by terrestrial laser scanning (TLS) systems is significantly influenced by the incidence angle. The incidence angle effect is an object property, which is mainly related to target scattering properties, surface structures, and even some instrumental effects. Most existing models focus on diffuse reflections of rough surfaces and ignore specular reflections, despite that both reflections simultaneously exist in all natural surfaces. Due to the coincidence of the emitter and receiver in TLS, specular reflections can be ignored at large incidence angles. On the contrary, at small incidence angles, TLS detectors can receive a portion of specular reflections. The received specular reflections can trigger highlight phenomenon (hot-spot effects) in the intensity data of the scanned targets, particularly those with a relatively smooth or highly-reflective surface. In this study, a new method that takes diffuse and specular reflections, as well as the instrumental effects into consideration, is proposed to eliminate the specular reflection effects in TLS intensity data. Diffuse reflections and instrumental effects are modeled by a polynomial based on Lambertian reference targets, whereas specular reflections are modeled by the Phong model. The proposed method is tested and validated on different targets scanned by the Faro Focus3D 120 terrestrial scanner. Results imply that the coefficient of variation of the intensity data from a homogeneous surface is reduced by approximately 38% when specular reflections are considered. Compared with existing methods, the proposed method exhibits good feasibility and high accuracy in eliminating the specular reflection effects for intensity image interpretation and 3D point cloud representation by intensity.
A Robust Algorithm for Estimating Surface Fractional Vegetation Cover from Landsat Data
Authors: Yang Linqing , Jia Kun , Liang Shunlin , Wei Xiangqin , Yao Yunjun , Zhang Xiaotong
Published: August 2017

Fractional vegetation cover (FVC) is an essential land surface parameter for Earth surface process simulations and global change studies. The currently existing FVC products are mostly obtained from low or medium resolution remotely sensed data, while many applications require the fine spatial resolution FVC product. The availability of well-calibrated coverage of Landsat imagery over large areas offers an opportunity for the production of FVC at fine spatial resolution. Therefore, the objective of this study is to develop a general and reliable land surface FVC estimation algorithm for Landsat surface reflectance data under various land surface conditions. Two machine learning methods multivariate adaptive regression splines (MARS) model and back-propagation neural networks (BPNNs) were trained using samples from PROSPECT leaf optical properties model and the scattering by arbitrarily inclined leaves (SAIL) model simulations, which included Landsat reflectance and corresponding FVC values, and evaluated to choose the method which had better performance. Thereafter, the MARS model, which had better performance in the independent validation, was evaluated using ground FVC measurements from two case study areas. The direct validation of the FVC estimated using the proposed algorithm (Heihe: R2 = 0.8825, RMSE = 0.097; Chengde using Landsat 7 ETM+: R2 = 0.8571, RMSE = 0.078, Chengde using Landsat 8 OLI: R2 = 0.8598, RMSE = 0.078) showed the proposed method had good performance. Spatial-temporal assessment of the estimated FVC from Landsat 7 ETM+ and Landsat 8 OLI data confirmed the robustness and consistency of the proposed method. All these results indicated that the proposed algorithm could obtain satisfactory accuracy and had the potential for the production of high-quality FVC estimates from Landsat surface reflectance data.
Deriving Hourly PM2.5 Concentrations from Himawari-8 AODs over Beijing–Tianjin–Hebei in China
Authors: Wang Wei , Mao Feiyue , Du Lin , Pan Zengxin , Gong Wei , Fang Shenghui
Published: August 2017

Monitoring fine particulate matter with diameters of less than 2.5 μm (PM2.5) is a critical endeavor in the Beijing–Tianjin–Hebei (BTH) region, which is one of the most polluted areas in China. Polar orbit satellites are limited by observation frequency, which is insufficient for understanding PM2.5 evolution. As a geostationary satellite, Himawari-8 can obtain hourly optical depths (AODs) and overcome the estimated PM2.5 concentrations with low time resolution. In this study, the evaluation of Himawari-8 AODs by comparing with Aerosol Robotic Network (AERONET) measurements showed Himawari-8 retrievals (Level 3) with a mild underestimate of about −0.06 and approximately 57% of AODs falling within the expected error established by the Moderate-resolution Imaging Spectroradiometer (MODIS) (±(0.05 + 0.15AOD)). Furthermore, the improved linear mixed-effect model was proposed to derive the surface hourly PM2.5 from Himawari-8 AODs from July 2015 to March 2017. The estimated hourly PM2.5 concentrations agreed well with the surface PM2.5 measurements with high R2 (0.86) and low RMSE (24.5 μg/m3). The average estimated PM2.5 in the BTH region during the study time range was about 55 μg/m3. The estimated hourly PM2.5 concentrations ranged extensively from 35.2 ± 26.9 μg/m3 (1600 local time) to 65.5 ± 54.6 μg/m3 (1100 local time) at different hours.
Erosion Associated with Seismically-Induced Landslides in the Middle Longmen Shan Region, Eastern Tibetan Plateau, China
Authors: Ren Zhikun , Zhang Zhuqi , Yin Jinhui
Published: August 2017

The 2008 Wenchuan earthquake and associated co-seismic landslide was the most recent expression of the rapid deformation and erosion occurring in the eastern Tibetan Plateau. The erosion associated with co-seismic landslides balances the long-term tectonic uplift in the topographic evolution of the region; however, the quantitative relationship between earthquakes, uplift, and erosion is still unknown. In order to quantitatively distinguish the seismically-induced erosion in the total erosion, here, we quantify the Wenchuan earthquake-induced erosion using the digital elevation model (DEM) differential method and previously-reported landslide volumes. Our results show that the seismically-induced erosion is comparable with the pre-earthquake short-term erosion. The seismically-induced erosion rate contributes ~50% of the total erosion rate, which suggests that the local topographic evolution of the middle Longmen Shan region may be closely related to tectonic events, such as the 2008 Wenchuan earthquake. We propose that seismically-induced erosion is a very important component of the total erosion, particularly in active orogenic regions. Our results demonstrate that the remote sensing technique of differential DEM provides a powerful tool for evaluating the volume of co-seismic landslides produced in intermountain regions by strong earthquakes.
Discrimination of Transgenic Maize Kernel Using NIR Hyperspectral Imaging and Multivariate Data Analysis
Authors: Feng Xuping , Zhao Yiying , Zhang Chu , Cheng Peng , He Yong
Published: August 2017

There are possible environmental risks related to gene flow from genetically engineered organisms. It is important to find accurate, fast, and inexpensive methods to detect and monitor the presence of genetically modified (GM) organisms in crops and derived crop products. In the present study, GM maize kernels containing both cry1Ab/cry2Aj-G10evo proteins and their non-GM parents were examined by using hyperspectral imaging in the near-infrared (NIR) range (874.41–1733.91 nm) combined with chemometric data analysis. The hypercubes data were analyzed by applying principal component analysis (PCA) for exploratory purposes, and support vector machine (SVM) and partial least squares discriminant analysis (PLS–DA) to build the discriminant models to class the GM maize kernels from their contrast. The results indicate that clear differences between GM and non-GM maize kernels can be easily visualized with a nondestructive determination method developed in this study, and excellent classification could be achieved, with calculation and prediction accuracy of almost 100%. This study also demonstrates that SVM and PLS–DA models can obtain good performance with 54 wavelengths, selected by the competitive adaptive reweighted sampling method (CARS), making the classification processing for online application more rapid. Finally, GM maize kernels were visually identified on the prediction maps by predicting the features of each pixel on individual hyperspectral images. It was concluded that hyperspectral imaging together with chemometric data analysis is a promising technique to identify GM maize kernels, since it overcomes some disadvantages of the traditional analytical methods, such as complex and monotonous sampling.