bluuebunny/crossref_metadata_2025 huggingface dataset:
A Bird’s Eye View on the Integration of Artificial Intelligence (AI) In Ayurveda
Authors: Buvana V. Mundargi  , Vaishnavi Mutalikdesai  , Sajitha K  , Deepthi R  , Ahana Balakrishnan
Published: November 2024

The integration of Artificial Intelligence (AI) into Ayurveda marks a significant advancement in traditional medical practices. This review article explores AI's multifaceted uses and relevance in the conventional Healthcare industry and Ayurveda. It also highlights the transformative potential of AI in Ayurveda while acknowledging the importance of maintaining the holistic essence of traditional practices. By embracing AI, Ayurveda can evolve to meet contemporary healthcare demands, offering a synergistic approach that combines ancient wisdom with cutting-edge technology. The article concludes with a discussion about the future of Ayurveda in the era of Artificial Intelligence.
Advanced Technologies for Teaching Rachana Sharir: Implications for Academic Education
Authors: Deepshikha  , Yogesh D. Kutte
Published: November 2024

The study of Rachana Sharira is a cornerstone of educational programs in the biological and healthcare fields. It is crucial that the teaching methods and instructional strategies used in this subject effectively prepare students. Traditionally, Rachana Sharira has been taught through a combination of lectures and hands-on practical sessions involving cadaver dissections and pre-dissected specimens. However, with the advent of modern digital technologies, such as smartphones, QR codes, and virtual reality, along with advanced imaging techniques like radiography, ultrasonography, MRI, and CT scans, the landscape of Rachana Sharira education is evolving. This review aims to explore how these innovative tools are being integrated into academic settings to enhance the diversity and effectiveness of Rachana Sharira teaching, ultimately improving students' understanding of the subject and its clinical applications.
The Role of Yoga in Enhancing Decision Making: A Research Perspective
Authors: Patel Kaminaben Jayantilal  , Anil Kashyap
Published: November 2024

This research explores the impact of yoga on enhancing decision-making abilities from a comprehensive research perspective. “Yoga, an ancient practice encompassing physical postures, breathes control, and meditation”, has gained attention in contemporary psychology and neuroscience for its potential cognitive benefits. This research aspires to analyze relationship among “Yoga practice & decision-making processes”, examining how regular “yoga practice” may influence cognitive functions relevant to decision making. The implications of these findings for personal well-being, professional performance, and organizational effectiveness are discussed, emphasizing the importance of integrating yoga-based interventions into educational, clinical, and corporate settings. Finally, avenues for future research are proposed, including longitudinal studies to examine “long-term provoke of yoga practice” on decision making and randomized controlled trials to establish causal relationships. Overall, this research underscores the multifaceted benefits of yoga in enhancing cognitive functions and informs strategies for optimizing decision-making processes in diverse contexts.
Review of research work done on Nishamalaki in type 2 Diabetes at institute of Teaching and Research in Ayurveda, Jamnagar
Authors: Poorvi P. Mahabdi  , Kirtesh N Agey  , Dilip Prajapati  , BJ Patgiri
Published: November 2024

Background: Nisha and Amalaki Churna are most commonly prescribed drugs used individually as well as in combination with other drugs in various diseases by Ayurvedic practitioners. The use of Nisha and Amalaki in Prameha is found in various classical texts, including Brihatrayees, Chakradatta, Bhaishajya Ratnavali among others. Diabetes is a major cause of health concern affecting around 10.5% of population. The most worrisome part is that its incidence is on the rise even in rural areas. Prameha (Madhumeha) wsr to Type 2 Diabetes) has adverse effects on many physiological processes and anatomical structures in the body (Saptadushya) and is considered as Mahagada. Aim of the present study was to compile such research works carried out on Nishamalaki at ITRA, Jamnagar and provide brief information about the studies. Material & methods: Total nine studies on Nishamalaki were screened from various PG departments of Institute of Teaching and Research in Ayurveda, Jamnagar. Results and Conclusion: All studies revealed that Nishamalaki reduces the clinical symptoms of Diabetes. The clinical efficacy has been evaluated in both type 1 (in modified form) and type 2 Diabetes. Satisfactory response with a decrease in the intensity of signs and symptoms was reported in all the studies. No adverse effects were reported in any of these studies.
A Pharmaceutical Study on Panchanan Rasa
Authors: Satyam Bhargava  , Vivek Awasthi  , Omvir Singh
Published: November 2024

Rasa Shastra is a specialized branch of Indian system of traditional medicine which mainly deals with the use of metals, minerals and herbs along-with the application of varied principles of Alchemy. Panchanan Rasa a chief reference from Rasa Ratna Sammuchya 14/09 was taken for Hridya Roga. It is a herbo-mineral preparation made finally with the use Kharal Yantra so called Kharaliye Rasayan, & is given after proper Mardan only in powder form with vehicle indicated for administering it. In recent scenario Hridya Roga is becoming a major concern disease every 1 in 10 person is suffering from sudden/chronic heart/artery disease with varied etiology & also patients are not able to afford such costly intervention to manage it, so effort is made to do pre-clinical study on the formulation & get some data to go for further clinical study in future.
Classical Review on Kashtartava
Authors: Neha Mamgain  , Akansha Anupam
Published: November 2024

Kashtartava (Dysmenorrhea) or painful menstruation is one of the leading causes for maximum absenteeism of females from school or workplace. Though it is not a serious problem but it definitely affects the quality of life and efficiency. In Ayurveda, gynecological disorders are described under Yonivyapad, Aartavadushti and Pradara. Few Yonivyapads resemble the clinical presentation of dysmenorrhea. Pradara refers to heavy or prolonged bleeding which may or may not be painful. The normal formation and expulsion of menstrual blood is the Karma of Apana Vayu. Therefore the basic line of treatment is pacifying of Vayu. It can be treated at OPD level with the use of oral medication of Panchakarma procedures.
The Ayurvedic management of Spastic Paralysis w.s.r. Pakshaghata: A Case Report
Authors: Ratnesh Kumar Shukla  , Shraddha Sharma  , Shrikant Lodhi  , Swati Nagpal  , Vivek Sharma
Published: November 2024

In Ayurveda, Vata Dosha is considered to play a significant role in neurological health due to its association with movement and communication within the body. Vata governs the nervous system and is linked to the movement of nerve impulses and the coordination of bodily functions. When Vata is imbalanced, it can contribute to various neurological issues, including Nervous system disorders, Mental Health Issues, Cognitive Function, and Movement Disorders. Vata Dosha is associated with the movement and function of the nervous system, and imbalances can contribute to spastic paralysis (Pakshaghata). The pathology of paralysis related to Vata dosha is understood through its effects on the body’s neurological and muscular systems. Vata Dosha influences paralysis by nerve Impairment, muscle dysfunction, circulatory Issues and joint and tissue degradation which may be associated with paralysis. In this study, an attempt has been made to describe the scientific effects of Panchakarma procedures and Shamana Aushadha in this case.
Basti as Ardha Chikitsa in the management of Vata-Pitta Samsrushta Grudrasi - A Case Report of Lumbar Spondylosis
Authors: Shreepriya Shirahatti  , Raja Rajeshwari N.M.
Published: November 2024

Lumbar Spondylosis is the commonly observed chronic degenerative disorder especially in the geriatric age group. This signifies that disorder is majorly due to Dhatu Kshaya (~depletion of body building and sustaining factors). In the present case report of Lumbar Spondylosis, was diagnosed as Vata Pitta Samsrushta Grudrasi (~sciatica formed by Vata and Pitta Dosha in their equal dominance) with the application of Trividha Bodhya Samgraha (~cause, situation and nature of disease). A 53 year housewife hailing from rural sector of Jangala Desha (dry area) reported with severe burning sensation in right foot, low backache, referred pain in right calf associated with numbness. Vata and Pitta were elicited as Sthanika (~functional unit of its own place) and Agantu Dosha (~functional unit entered from other part) respectively through Samsarga Dosha Laxana. Yapana Basti (~Enema Therapy) schedule was designed to pacify Pakvashayagata Vata-Pitta (~Vata and Pitta situated in lower gut). Qualitative assessment done before and after treatment revealed successful outcomes where score reduced from 12 to 2 indicating improved quality of life. Basti acts as Ardha Chikitsa (~half treatment) when proper Yukti (planning) is applied in designing protocol, selecting appropriate formulations by incorporating multiple Chikitsa Siddhanta (~treatment principle) such as Sthanivat Chikitsa.
Management of Plaque Psoriasis with Multimodal Treatment of Ayurveda - A Case Report
Authors: Pranesh Prakash Gaikwad  , Manmeet Kaur
Published: November 2024

Psoriasis is the immune system problem that causes skin to revitalize at faster rate. It’s the chronic disease that has psychological and social impact on patient’s life. This condition had been narrated many decennium ago but proper aetiology and its cure remain under researched. In Ayurveda this multifaceted etiology disease needs multimodal treatment. The modern treatment provides only temporary relief with too many serious side effects. The treatment embraced here was in accordance with ayurvedic Samprapti. This case report details the successful management of plaque psoriasis in a 32-year-old female patient using a multimodal treatment approach, which incorporated Panchakarma, a traditional Ayurvedic detoxification therapy. The patient presented with erythematous plaques on forehead, neck region, lateral surface of legs and at arms along with itchy and burning skin. Auspitz sign and Koebner phenomenon was positive. Diagnosis made on the basis of Sign and Symptoms. After a thorough evaluation of the patient's constitution and the nature of the disease, a customized Panchakarma protocol was devised involving Virechana (Purgation) followed by Basti (medicated enema) along with Shamana Chikitsa (Internal Medication). The results revealed a remarkable improvement in the patient's psoriasis lesions, with a significant reduction in PASI scores, reduction in scaling, erythema, and in duration. The patient reported a substantial reduction in itching and discomfort. This case report emphasizes the potential of Panchakarma as an adjunctive therapy for plaque psoriasis, highlighting the holistic and personalized approach of Ayurveda in managing chronic skin conditions. Further research and larger-scale studies are warranted to confirm the effectiveness of Panchakarma in the treatment of psoriasis and to observe its long-term benefits and safety profile.
Ayurvedic approach to managing Joint Disorders: Case Studies
Authors: Kriti Joshi  , L.C. Harjpal  , Shweta Singh
Published: November 2024

Around the world, Bone and Joint-related disorders are common and can be extremely painful and impairing. Due to long-term disability and the high expense of surgical procedures, these conditions not only harm people's quality of life but also place a significant financial burden on them. Commonly Joint diseases like Sandhivata, Aamvata and Vatarakta have been mentioned in most classic Ayurvedic texts from ancient times. Another group of disorders known as Vatavyadhi assembles neuro-musculoskeletal conditions with varying etiopathogenesis. An Ayurvedic approach to disease classification involves arranging the various clinical conditions into a particular place, mainly based on their defining characteristics. Ayurvedic treatment offers a comprehensive and successful approach to managing joint disorders by reducing inflammation, improving range of motion, and promoting overall joint health and by integrating conventional knowledge with contemporary research, giving patients sustainable and natural relief and recovery. This article case report has been presented for every bone and joint-related disorder with their treatment protocol given in Ayurvedic Classics.
Ayurvedic management of Vipadika - A Case Report
Authors: Sinsha A.S.  , Rashmita Tiga  , Pragya Priyadarsini Mallik  , Sonalika Jena
Published: November 2024

Vipadika, categorized as a type of Kshudra Kustha in Ayurveda, presents as a chronic dermatological condition primarily affecting the palms and soles, characterized by symptoms such as Pani-Pada Sphutana (fissures), Teevra Vedana (severe pain), Manda Kandu (itching), and Saraga Pidika (red patches). Vipadika can be correlated to Palmoplantar psoriasis, which is a prevalent chronic inflammatory skin disorder characterized by erythematous plaques affecting the palms and soles significantly impairing daily function and quality of life. Ayurvedic management of Vipadika emphasizes Shamana Oushadhis aimed at pacifying aggravated Doshas, alleviating manifestations of Vipadika. Integral to this approach are Nidana Parivarjana and Pathya Ahara-Vihara Sevana to prevent recurrence. In the present case, a male patient with complaints of dryness, itching, cracking, scaling, and hyperpigmentation of skin of bilateral feet and bleeding from cracks for the last 6 months came to Kayachikitsa OPD and was diagnosed and treated as Vipadika with the Shamana Oushadhis. The patient's condition demonstrated a substantial improvement, with a marked reduction in symptoms evident within 21 days, suggesting effective management of Vipadika through Ayurveda.
A Review on Lepa Kalpana for Skin Diseases: Inherent Topical Formulations described In Charaka Samhita
Authors: Sneha Shantaram Chanekar  , P.D. Dongare  , V.E. Gogate
Published: November 2024

Skin is the most exposed and the largest organ of the body, serving as a barrier of defense. Its pathology needs to be treated through all possible ways. Acharya Charaka has classified Chikitsa into Antahparimarjan and Bahirparimarjana. The later one uses the topical application of various Dravya which helps to get rid of symptoms such as Shoola, Vaivarnya, Shotha, Strava, Kandu etc. The Charaka Samhita being the most ancient and prominent Bruhatrayi text of Chikitsa has already given number of Lepa formulations. Among these, 58 Lepa are indicated in skin diseases. Besides the tiding process of making them these preparations has an excellent immediate result. Here an attempt is made to cover all the preparations mentioned by Charaka Acharya for skin diseases to have an overlook on.
Ayurvedic management of Amalpitta - A Case Report
Authors: Akanksha  , Munna Lal Prajapati  , Rajveer Sason
Published: November 2024

Amlapitta is one of the most prevalent diseases in today's culture. It can be found in people of diverse ages, socioeconomic backgrounds, and communities. Amlapitta is the most common illness in the modern period. Because of indulgence in incompatible food habits and activities, Amlapitta is the most common disorder in today's fast increasing culture. Materialistic lifestyles drive people to lead hectic, stressed lives with little regard for good eating habits. Hyperacidity is a condition that occurs when the stomach produces too much acid. The defining characteristics of Amlapitta are described in classical Ayurvedic books as Avipaka (indigestion), Urodaha (chest burning), Utklesha (nausea), Aruchi (anorexia), and Tikta-Amlodgara (sour and bitter belching). A 38-year-old male patient arrived at the outpatient department complaining of burning in his chest, sour eructation, anorexia, etc. Vitals are normal at the time of the examination. Based on this, the patient was treated with Kamadudha rasa, Avipattikar churana, Hingavashtak Choorna, and Sutshekar Rasa. It was advised to the patient to follow up every fifteen days. The patient was instructed to keep to dietary and lifestyle guidelines in addition to taking medication.
Ayurveda management of Visarpa (Herpes zoster) - A Case Study
Authors: Akarsha Krishna S  , Rakshith NN  , Ashwini Kumar S. Bharathi
Published: November 2024

Skin is the largest organ of the body which acts as a first line of defence in providing resistance to the body. The aggravation of various Dhatus and Doshas result in skin diseases. Visarpa is an acute condition with a quick spreading involving mainly skin, blood, lymph and muscle tissue due to vitiation of all three Doshas. As the basic nature of the disease is Rakta and Pitta predominant, management is focused on Shodhana, Rakthamokshana, Langhana, Shamana, Lepa Chikitsa. This case study is an attempt to evaluate the role of Ayurvedic management in Visarpa. A 50 year-male presented with vesicular lesions on his chest, below the left axillary region and back associated with mild itching, burning sensation and pain. He was approached with Shodhana and Shamana therapies which showed significant improvement in the condition.
Ayurvedic management of Limb Girdle Muscular Dystrophy - A Case Report
Authors: Chetana Mugali  , Sanathkumar DG
Published: November 2024

Limb girdle muscular dystrophy is a rare, progressive and genetically heterogeneous group of muscular dystrophies that causes weakness and wasting of muscles. LGMD primarily affects the hip and shoulder muscles. There is no specific treatment for the LGMD in the allopathic science; it is managed through only supportive care. In the present case study, the patient with LGMD was treated with Shamana and Panchakarma Chikitsa and disease is managed successfully. An Ayurvedic diagnosis of the condition based on the presentation of the disease can be taken as Mamsagata Vata (neuromuscular diseases). The patient was treated with Balashwagandha Lakshadi Taila Abhyanga followed by Shashtikashali Pinda Swedana and Mustadi Yapana Basthi along with Shamanoushadhi. There was symptomatic improvement in the patient’s condition. The present case study suggests that LGMD can be satisfactorily managed with Ayurvedic oral and Panchakarma therapy
A Case Study of Urinary Tract Infection and its Ayurveda Management
Authors: Aarti Bhandule  , Naresh Jain  , Preeti Jain
Published: November 2024

A Urinary Tract Infection (UTI) is the most common bacterial infection encountered in daily medical practice. It is more prevalent in females than males due to the shorter urethra in females, which allows bacteria a quicker access to the bladder. One in five women develop UTI at least once in her lifetime. UTIs in men are uncommon, but when they do occur, they can be very serious. In Ayurveda, the symptoms of UTI closely resemble a condition known as Mutrakriccha. Acharya Charaka has explained eight types of Mutrakriccha in Charaka Chikitsa Sthana 26. In this condition, the aggravated Pitta Dosha, along with Apana Vayu, reaches the Vasti (bladder) and affects the Mutravaha Srotas, leading to painful and burning urination. In this case report, a 50-year-old male patient presented with symptoms of urinary urgency, increased frequency, and intermittent burning urination for the past 1-2 months. He was diagnosed with UTI and was effectively managed with Syp. Neeri, Chandraprabha Vati, Gokshuradi Guggulu, Shweta Parpati, and Hajaralyahud Bhasma. The treatment resulted in significant improvement in signs, symptoms, and urine examination results. During follow-up visits, there were no recurrences of UTI. Ayurvedic management offers a promising alternative for treating Mutrakriccha.
Conceptual study of Non-Alcoholic Fatty Liver Disease and its management in Ayurveda
Authors: Pooja Hui  , Sonalika Jena  , Snehamayee Mishra
Published: November 2024

Non-alcoholic Fatty liver Disease (NAFLD) is a condition with excessive fat deposition in liver on refers to a broad spectrum of disorders characterized by fatty infiltration of the liver steatosis, steatohepatitis and cirrhosis. It is a growing cause of liver injury globally and is present in developed and developing countries. NAFLD is a broad term which describes the build up of excessive fat in the liver cells (hepatocytes) in the absence of excessive alcohol intake. It is a growing worldwide, due to obesity and insulin resistance leading to liver accumulation of triglycerides and free fatty acids. NAFLD encompasses a spectrum of liver Pathology with different clinical prognoses, from the simple accumulation of triglycerides within hepatocytes to more progressive steatosis with associated hepatitis, fibrosis, cirrhosis and in some cases hepatocellular Carcinoma. It is a global epidemic that ranges from isolated hepatic steatosis (NAFL) to Steatosis Plus inflammation (NASH) with or without fibrosis. Ayurveda described different types of Non-Communicable diseases, and NAFLD is one among them. In Ayurveda NAFLD can be interpreted as a Santarpanotha Vikara caused by Kapha Medo Dushti, getting Sthanasamshraya in Yakrit, which is Raktavaha Srotasmula and Pittasthana. In the initial stage of NAFLD, Kapha Meda Dushti occurs when Pitta gets involved in the pathogenesis, inflammatory changes occur which leads to the next stage of disease i.e., Non alcoholic steatohepatitis (NASH), When Vata comes involved fibrosis occurs which may end up in cirrhosis. So, the management should be the breakdown of pathological factors like Agnivaigunya, Srotorodha and Kaphamedo Dushti. This review will give a better knowledge of etiopathogenesis.
Diversidad de briofitas en un sitio contaminado por hidrocarburos de pozos petroleros abandonados en Patagonia, Argentina
Authors: Cottet Agustina C. , Soto-Mancilla Matias , Fernández Natalia V.
Published: November 2024

Antecedentes y Objetivos: Las briofitas se distribuyen por todo el mundo y juegan un papel crucial en sitios perturbados, actuando como organismos pioneros en sucesiones ecológicas posteriores a disturbios. El objetivo de este trabajo fue estudiar las briofitas que crecen en relación con sustratos contaminados con petróleo crudo y analizar su estado micorrícico arbuscular. Métodos: Las muestras se recolectaron a lo largo de un arroyo de la estepa norpatagónica (San Carlos de Bariloche, Río Negro, Argentina). Los especímenes examinados se recolectaron a lo largo de los márgenes del arroyo antes, durante y después del derrame de pozos petroleros abandonados. Las especies de briofitas fueron identificadas con base en características morfo-anatómicas. También se analizó la abundancia de micorrizas arbusculares (MA) en las plantas y el número de esporas MA en el suelo. Resultados clave: Se identificaron 16 especies de briofitas; una perteneciente a antocerotes, dos a hepáticas y el resto a musgos. Aunque ciertas plantas se asociaron principalmente con algunas de las ubicaciones estudiadas, las comunidades de briofitas en general no mostraron variaciones significativas a lo largo del gradiente de contaminación, mientras que el inóculo MA sí presentó variaciones. Conclusiones: Este estudio sugiere que ciertas especies de briofitas pueden tolerar las condiciones generadas por la contaminación con petróleo crudo y establecerse en las primeras etapas de la sucesión ambiental (por ejemplo, en lechos de petróleo crudo solidificado). Estos resultados proporcionan una base para futuros esfuerzos de restauración ecológica.
Shaping Consumers’ Attitude and Purchase Intention towards Halal Sustainable Organic Food Products
Authors: Putit Lennora , Joremi Leylawati , Johan Zaimy Johana , Heny  Hendrayati
Published: November 2024

Increased global recognition of organic food has prompted developed nations to adopt ecological agriculture concepts. This trend is also reflected within the sustainable Halal (permissible) organic food sector. This study examines whether Halal awareness, certification, social influences, and promotion affect consumers' attitude and subsequently, intention to purchase Halal organic food in Malaysia. Using convenient sampling technique, online surveys were conducted with 200 usable responses. A Smart PLS statistical software was used for data analyses. Results revealed that Halal awareness, certification, and social influence significantly affect attitudes, which, in turn, significantly influence consumers' intentions to purchase Halal organic food products. Implications are addressed.
Reduced Monocular Accommodation Abilities with Laptop Usage Under Scotopic Ambient Illumination
Authors: Ahmad Azmir , Rosli Saiful Azlan , Ai-Hong Chen , Allinjawi Kareem
Published: November 2024

Laptops are widely used even in dark scotopic rooms.  This study compares monocular accommodation statuses with laptop usage under three illuminations.  Thirty university students read on a laptop for 5 minutes under scotopic, mesopic, and photopic conditions.  The monocular amplitude of accommodation, accommodation facility, and accommodation error are measured for each illumination.  Repeated measure ANOVA shows a significant difference in the amplitude, facility, and error between different illuminations [F (1.49, 43.18) = 10.61, p<0.001], [F (1.65, 36.30) = 6.78, p=0.005] and [F (2, 56) = 3.65, p=0.032].  Scotopic illumination reduces monocular accommodation abilities with laptop usage.
An Analysis of Real Estate Market Responses towards Climate Resilient Policies in Malaysia and Indonesia
Authors: Syed Abdul Kader Sharifah Zubaidah , Rabe Noor Suzilawati , Mohd Yusoff Rahmawati , Sufian Azlinor
Published: November 2024

As global warming increases climate-related disasters, countries must address its impact on real estate. Malaysia’s National Policy on Climate Change, Green Building Index, and National Urbanisation Policy, along with Indonesia’s National Action Plan on Climate Change, Climate Resilience and Adaptation Strategy, and Disaster Management Law, highlight climate resilience in real estate. This study examines these policies and their effects on the real estate markets in Malaysia and Indonesia using qualitative methods. The findings reveal that property values in both countries have increased due to a growing emphasis on sustainability and durability in the market.
Reliability of Accuracy-Based Calibration in Quantifying Systematic Errors of Static LiDAR
Authors: Abd Razak Nur Nazura , Abbas Mohd Azwan , Kamarruzzaman Muhammad Aliff Haikal , Purwanto Hery , Mohd Hashim Norshahrizan , Mustafar Mohamad Asrul
Published: November 2024

The calibration of terrestrial laser scanners (TLSs) is crucial for ensuring high-quality 3D data. While system calibration often relies on precision-based methods without reference points, this study explores accuracy-based approaches incorporating reference values. TLS self-calibration was performed using point-based and line-based constraints with reference points established through close-range photogrammetry (CRP). The evaluation assessed calibration parameters (CPs), standard deviation, residuals, and correlation coefficient. Results show that the line-based approach improved accuracy by up to 60%, whereas the point-based method exhibited significant deviations. Consequently, while accuracy-based approaches can enhance TLS self-calibration, the line-based constraint is notably more effective.
Androgen Receptor Signaling Inhibitor Withdrawal Syndrome After Castration-resistant Prostate Cancer
Authors: HIROSHI MASUDA
Published: November 2024

Androgen-deprivation therapy is an extremely effective treatment for progressive prostate cancer. Previously, the first-line treatment for progressive prostate cancer was combined androgen blockade (CAB). If the disease progressed to castration-resistant prostate cancer, the administration of androgen receptor signaling inhibitors (ARSIs) was recommended. When elevated serum prostate-specific antigen (PSA) levels are seen during CAB treatment, it is important to suspect antiandrogen withdrawal syndrome (AWS), discontinue CAB, and monitor the changes in the serum PSA levels. If a reduction in the patient’s PSA levels is subsequently observed, antiandrogens should be discontinued and the patient should be followed, but if their PSA level rises they should be transitioned to ARSI treatment. Recently, there have been reports of withdrawal syndrome (WS) after ARSI treatment. With the increased use of ARSIs, such as abiraterone acetate, enzalutamide, apalutamide, and dalorutamide, it is necessary to consider ARSI WS when a patient’s serum PSA level increases during ARSI treatment. Unnecessary treatment can be avoided if the confirmation of ARSI WS is prioritized. Conversely, if it is not confirmed there is a risk that second-line treatment will be delayed. This is a review of recent studies of ARSI WS. It also discusses future prospects in this field.
Risk Factors for Adhesive Small Bowel Obstruction After Liver Cancer Surgery
Authors: YUKAWA NORIO , YAMADA TAKESHI , ICHIKAWA DAISUKE , AOYAMA TORU , KATAOKA KOZO , SHIOYA TAKESHI , TAMURA TOSHIHISA , SHIMOYAMA RAI , FUKAZAWA ATSUKO , KUMAMOTO KENSUKE , YAMASHITA NAOYUKI , HASEGAWA SUGURU , SAITO SHUJI , TAKEMASA ICHIRO , FUJITA FUMIHIKO , TANIAI NOBUHIKO , KAIBORI MASAKI , YOSHIDA HIROSHI
Published: November 2024

Background/Aim: Although the frequency of small bowel obstructions after liver surgery is generally considered low, previous studies have followed-up patients for less than a year, thus the incidence of small bowel obstructions several years after surgery is unknown. Furthermore, the rise in laparoscopic surgeries and the use of adhesion prevention materials may influence the occurrence of small bowel obstructions. This study aimed to assess the incidence of small bowel obstructions within a five-year period following liver surgery and identify the associated risk factors. Patients and Methods: This case series analysis analyzed patients who underwent liver surgery between April 2012 and March 2014 from 32 participating hospitals. Multivariate analysis was conducted to examine risk factors for small bowel obstructions. Results: A total of 953 patients were included in the analysis, and the incidence of small bowel obstructions was 1.6%. The incidence was significantly higher at 3.4% for surgeries related to metastatic liver cancer compared to other types of surgeries. Laparoscopic surgery had no significant effect on the incidence of SBO (p=0.72). There was no significant difference in the incidence of small bowel obstructions between surgeries that employed adhesion prevention materials and those that did not. Multivariable analysis revealed that longer surgical time and re-operation were independent risk factors for small bowel obstructions. Conclusion: The incidence of small bowel obstructions following surgery for metastatic liver cancer is significantly higher compared to other liver surgeries. Neither laparoscopic surgery nor adhesion prevention materials reduce its occurrence. Longer surgical time and re-operation are independent risk factors for small bowel obstructions.
Factors Associated With Infusion Reactions in Patients With Breast Cancer Receiving Trastuzumab
Authors: YAMAGUCHI RYUJI , UCHIYAMA MASANOBU , MIYAZAKI MOTOYASU , HAYASHI TOSHINOBU , OYABU KOHEI , NAKANO TAKAFUMI , MATSUO KOICHI
Published: November 2024

Background/Aim: Trastuzumab (TRA) is a key drug in human epidermal growth factor receptor type 2 (HER2)-positive breast cancer treatment. Infusion reactions (IR) with TRA are frequently observed in practice. Although the efficacy of premedication has been previously reported, it remains uncommon. The probability of severe IR due to TRA is low; however, when it does occur, it is associated with patient discomfort and expenditure of medical resources. This study aimed to analyze the factors associated with the occurrence of IR in patients with breast cancer who received TRA. Patients and Methods: We retrospectively studied 204 patients who underwent TRA for breast cancer treatment between September 2008 and June 2023, identifying factors influencing the occurrence of IR at the time of TRA administration. Results: A total of 182 patients were included in this study, and the incidence of IR was 25.8% (47/182 patients). Multiple logistic regression analysis showed that pertuzumab (PER) use, high alkaline phosphatase (ALP), and low high-density lipoprotein (HDL) cholesterol levels were associated with IR. Conclusion: IR should be considered when PER is combined with TRA. ALP and HDL cholesterol levels may be predictive markers of TRA-induced IR in patients with breast cancer.
C-reactive Protein-albumin-lymphocyte Index as a Novel Biomarker for Progression in Patients Undergoing Surgery for Renal Cancer
Authors: HIRATA SHI , FUJII NAKANORI , OKA SHINTARO , NAKAMURA KIMIHIKO , SHIMIZU KOSUKE , KOBAYASHI KEITA , HIROYOSHI TOSHIYA , ISOYAMA NAOHITO , SHIRAISHI KOJI
Published: November 2024

Background/Aim: Some patients with renal cell carcinoma (RCC) develop early or late recurrence after surgery. However, there is no clear consensus on which patients with postoperative RCC should be treated. This study aimed to establish a biomarker for selecting patients who are at a higher risk of relapse following renal cancer surgery. Patients and Methods: A total of 378 patients who underwent nephrectomy or partial nephrectomy for a diagnosis of RCC at our hospital were included, with a focus on pT3 cases at high risk of recurrence. Factors associated with postoperative progression, including pathological and hematological parameters, were examined. Results: Sarcomatoid features, Fuhrman grade 4, and C-reactive protein-albumin-lymphocyte (CALLY) index were statistically significant predictive factors for progression-free survival after surgery (p<0.0011, p=0.0047, and p<0.0001, respectively). In the multivariate Cox proportional regression analysis, the CALLY index was the most statistically significant predictor of the risk of postoperative recurrence (p=0.0002). Conclusion: In addition to the existing risk factors for RCC recurrence, such as sarcomatoid features and Fuhrman grade, we propose that the CALLY index is a predictor of postoperative recurrence and that patients with a low CALLY index are good candidates for postoperative treatment. Our study may help select patients with pT3 disease with a high risk of recurrence who require postoperative treatment.
High Subcutaneous Adipose Tissue Radiodensity Predicts Poor Prognosis in Patients With Gastric Cancer
Authors: IIDA SHINICHIRO , MATSUMOTO YASUNORI , TOYOZUMI TAKESHI , OTSUKA RYOTA , SHIRAISHI TADASHI , MORISHITA HIROKI , MAKIYAMA TENSHI , NISHIOKA YURI , YAMADA MASANARI , HIRATA ATSUSHI , HAYANO KOICHI , OHIRA GAKU , KANO MASAYUKI , MATSUBARA HISAHIRO
Published: November 2024

Background/Aim: Although the impact of body composition on cancer treatment outcomes of patients with cancer has been increasingly reported, it is still unclear whether the radiodensity of subcutaneous adipose tissue (SAT) on computed tomography (CT) images has a prognostic impact on patients with gastric cancer. We measured muscle and SAT profiles on CT and performed an integrated analysis with clinicopathologic factors. Patients and Methods: We retrospectively analyzed 230 patients with gastric cancer who underwent gastrectomy between June 2016 and December 2020. SAT radiodensity (SAT-R), and skeletal muscle index (SMI) were measured in preoperative CT images. These were compared with clinicopathologic factors, overall survival (OS), and recurrence-free survival (RFS). Results: High SAT-R was significantly associated with older age (p=0.003) and lower BMI, lymphocyte, hemoglobin, γ-GTP, cholinesterase, albumin, and triglyceride values (p<0.001, <0.001, 0.027, 0.032, <0.001, 0.001, and <0.001, respectively). In the univariate analysis, high SAT-R, and low SMI were significantly associated with poor OS (p=0.003 and <0.001) and poor RFS (p=0.014 and 0.011). In the multivariate analysis by Cox proportional hazard model, high SAT-R and low SMI were identified as independent prognostic factors for poor OS (p=0.037 and 0.007). Conclusion: High SAT-R on preoperative CT was associated with poor OS in patients with gastric cancer after gastrectomy. SAT-R has a potential to be a novel prognostic marker for surgically treated patients with gastric cancer.
Correlation Between Serum and Tissue SIRT1 Levels in Patients With Esophageal Squamous Cell Carcinoma
Authors: MORISHITA HIROKI , OTSUKA RYOTA , TOYOZUMI TAKESHI , MATSUMOTO YASUNORI , SEKINO NOBUFUMI , OKADA KOICHIRO , SHIRAISHI TADASHI , KAMATA TOSHIKI , IIDA SHINICHIRO , MAKIYAMA TENSHI , NISHIOKA YURI , YAMADA MASANARI , MATSUBARA HISAHIRO
Published: November 2024

Background/Aim: Identifying prognostic and molecular markers as therapeutic targets for esophageal squamous cell carcinoma (ESCC) could enhance the efficacy of multidisciplinary treatments. While tissue expression of sirtuin 1 (SIRT1) has been linked to tumor progression in ESCC, prognostic significance of serum SIRT1 levels and their correlation with tissue SIRT1 remains unexplored. This study aimed to investigate the correlation between serum and tissue SIRT1 levels in patients with ESCC. Patients and Methods: A total of 38 patients diagnosed with ESCC who were untreated preoperatively were recruited for this study. SIRT1 expression in the surgical specimens was assessed through immunostaining, while serum SIRT1 levels were measured using an enzyme-linked immunosorbent assay. We analyzed the association between tissue and serum SIRT1 levels, clinicopathological features, and patient prognosis. Results: Positive SIRT1 expression in tissue was significantly associated with deeper tumor depth (p=0.020). It was also significantly associated with poorer overall survival (OS) and relapse-free survival (RFS) (p=0.041 and p=0.012, respectively). Elevated serum SIRT1 levels were significantly correlated with increased tumor depth and weight loss (p=0.012 and p=0.030). While higher serum SIRT1 levels tended to be associated with poorer OS (p=0.069), no significant correlation was found between SIRT1 expression in tissue and its concentration in serum. Conclusion: SIRT1 tissue expression may be a valuable prognostic marker in ESCC. However, the clinical significance of serum SIRT1 levels appears to differ from that of its tissue expression. Future research is required to clarify the role of serum SIRT1 in ESCC.
Efficacy of Paclitaxel and Cetuximab in Recurrent/Metastatic Oral Cancer Cases Following Superselective Intraarterial Chemoradiotherapy: A Retrospective Cohort Study
Authors: SAKUMA KANAME , KII TOMOYUKI , MACHIDA TOKO , KIKUCHI YOSUKE , YODA MASAKI , TOYA SHUJI , TANAKA AKIRA
Published: November 2024

Background/Aim: The therapeutic efficacy of the paclitaxel (PTX) + cetuximab (Cmab) combination regimen was investigated in patients with recurrence or metastasis after superselective intraarterial chemoradiotherapy (SSIACRT) for oral cancer, and the safety was retrospectively examined. Patients and Methods: All enrolled patients with advanced oral cancer or who had refused surgery over 10 years from December 2012 to December 2022 underwent SSIACRT for 6 to 9 weeks [cisplatin (CDDP): total 160-630 mg/m2 and radiotherapy: total 50-70 Gy]. Nine cases (tongue cancer, maxillary gingival cancer, and mandibular gingival cancer; three cases each) were subjected to PTX + Cmab therapy. Recurrence or metastases were observed within six months after the onset of treatment, complicating the conduct of salvage surgery. Cmab (first dose: 400 mg/m2 and second and following doses: 250 mg/m2) and PTX (80 mg/m2) were administered weekly. Results: The overall response rate was 44.4% (four of nine cases), and the disease control rate was 88.9% (eight of nine cases), whereas the median progression-free survival was seven months, and the overall survival was 11 months. Grade 3-4 adverse events were neutropenia in 33.3% of the cases, leukopenia in 55.6%, anemia in 22.2%, and acneiform skin rash in 22.2%. Based on the above, PTX + Cmab therapy for recurrent and metastatic cases after SSIACRT had comparable results to other second-line modalities and enabled to cope with the side effects of myelosuppression. Conclusion: PTX + Cmab therapy may be an effective treatment mode for recurrent or metastatic head and neck cancer resistant to CDDP after SSIACRT treatment.
Short-term Outcomes of Robot-assisted Colectomy Using the Overlap Method for Right-sided Colon Cancer
Authors: ISHII MASATSUGU , NITTA TOSHIKATSU , UEDA YASUHIKO , TAKI MASATAKA , KUBO RYUUTARO , HOSOKAWA NORIHIRO , ISHIBASHI TAKASHI
Published: November 2024

Background/Aim: The recent development of minimally invasive surgery has led to transition from laparoscopic right colectomy (LC) to robot-assisted right colectomy (RC) in Japan. However, it is unclear whether the introduction of RC in municipal hospitals could be as safe as that in high-volume centers in Japan. Therefore, this retrospective study aimed to compare the short-term operative outcomes of RC and LC for right colon cancer at a local municipal hospital in Japan. Patients and Methods: Patients with stage I-IV right colon cancer who underwent elective RC or LC between January 2021 and July 2023 were retrospectively analyzed. Patients with double cancer and those who underwent delta anastomosis were excluded. Postoperative surveillance included patient interviews, physical examinations, tumor marker examinations, and whole-body computed tomography every six months. Results: Forty patients were analyzed, and 24 (60%) and 16 (40%) patients assigned in the LC and RC groups, respectively, were compared. The operative time, bleeding, postoperative complications, and pathological examinations did not differ significantly between the LC and RC groups. Conclusion: RC using overlapping anastomoses was comparable to LC in terms of short-term operative outcomes. The introduction of RC with overlapping anastomosis is a feasible surgical technique.
Evaluación a elementos de Atención primaria en salud en Colombia, desde la perspectiva de enfermería
Authors: Gómez Natalia Rocio , Villalobos Gladys Edith
Published: November 2024

Objective To understand how the essential elements of Primary Health Care (PHC) have been measured in Colombia. Materials and methods Qualitative research to review the literature using the databases of PubMed, BVS, ScienceDirect, RedalyC, Scielo, EBSCO and Google scholar, identifying the keywords in the databases. Subsequently, the scientific and general information on the subject was collected and categorized. Results 25 files were analyzed including articles, reports, scientific texts, degree thesis; where it was possible to show that although there are texts that evaluate the functions of PHC, there is no effective application of these in the entire country, on the contrary, with the passing of the years and regardless of the territory the greatest deficiency It is in the family and community approach, followed by the inequity in access and comprehensiveness that depends on the social security system to which the person is affiliated. Conclusions The elements of PHC should be executed in urban and rural populations; where the action must be intersectoral, cross-sectoral, community and comprehensive; compliance with PHC and its elements make it possible to guarantee the right to health and reduce inequities.
Situación de salud en población migrante atendida por la cruz roja colombiana, 2020
Authors: Gallego Ángela Carmenza , Moreno Benjamín , López Jennifer Alejandra , Bernal Oscar Aníbal
Published: November 2024

Objective. To describe the prevalence of health events identified by the Colombian Red Cross -CRC- in different points of care during 2020; in humanitarian care directed to migrant and host population, fulfilling the mission of preventing and alleviating human suffering (1). Materials and methods. Descriptive, retrospective cross-sectional study of the population attended with 204,647 consultations made by health professionals, 67.3% (137,698) were women, of whom 80% (30,768) were between 15 and 24 years of age. The databases obtained were processed in the statistical analysis program R Studio version 1.4.1106.  Results. The humanitarian crisis generated by the migratory flow and its economic, social and political effects determine deterioration in the health and living conditions of migrant and host populations as an expression of social inequalities. The main pathology in children from 5 to 14 years old was parasitic and respiratory diseases, from 15 to 24 years old was contraceptive counseling and high-risk pregnancy, and in those over 60 years old was arterial hypertension. Conclusions Contribute with analysis of the situation for the migrant and host population before the State and organizations of the Health Cluster, orienting a response to the humanitarian crisis generated by the migratory flow.
Contribución del cuidador familiar al autocuidado del paciente con Insuficiencia Cardiaca en un centro especializado
Authors: Herrera H Jorge Luis , Oyola L Edinson , Llorente P Yolima Judith
Published: November 2024

The family caregiver plays an important role in the self-care of patients with heart failure; Supportive relationships improve outcomes for people with heart failure and caregiver decisions contribute to the maintenance of self-care. Objective: to determine the contribution of the family caregiver, to the self-care of the patient with Heart Failure, who attends a specialized center in the city of Monteria - Colombia. Materials and methods: descriptive scope study, quantitative, transversal approach. The sample was 222 caregivers of patients with Heart Failure, the sampling was of an intentional type with 99% confidence level and 1% margin of error. Results: 222 caregivers met the inclusion criteria established in the design of the present research; These were characterized by being mostly women (74%), the average age was 46 years. The caregiver's contribution to patient self-care was high, with an average of 80 points. Conclusions: other research is necessary to identify a panorama in Colombia, which in turn contributes to what is described worldwide.
Claves del bienestar: Una mirada desde la neurociencia
Authors: Ensuncho Hoyos Carlos Federico
Published: November 2024

Objetivo Describir desde las neurociencias los factores claves para gozar de bienestar y salud cerebral a través de una revisión sistemática de literatura científica. Materiales y métodos investigación de corte cualitativo de revisión sistemática de artículos en las bases de datos de Scopus, ScienceDirect y Google Scholar. La búsqueda incluyo referencias publicadas a partir del año 2006 en idiomas español e inglés que presentaran información científica desde las neurociencias sobre bienestar, felicidad, ejercicio, nutrición y salud cerebral Resultados Un total de 593 referencias fueron recuperadas, de las cuales 62 fueron seleccionadas para su análisis. Se hallaron estudios relevantes y actualizados acerca del estilo de vida de los seres humanos, y el impacto de este en la salud y el bienestar en general. Para ello se tomaron en cuenta documentos en los que se identificaron hábitos, conductas y comportamientos que podrían resultar beneficiosos o perjudiciales para el bienestar en general y en especial para la salud cerebral. Conclusiones El bienestar general y una buena salud cerebral están relacionados con diversos factores biológicos, socioemocionales y culturales, entre los que se destacan la felicidad, el agradecimiento, las relaciones sociales y afectivas, la nutrición, la actividad física y el sueño.