bluuebunny/crossref_metadata_2025 huggingface dataset:
IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport
Authors: Anitei Mihaela , Bruno Francesca , Valkova Christina , Dau Therese , Cirri Emilio , Lascano Iván Mestres , Calegari Federico , Kaether Christoph
Published: January 2024

Mutations in theIER3IP1(Immediate Early Response-3 Interacting Protein 1) gene can give rise to MEDS1 (Microcephaly with Simplified Gyral Pattern, Epilepsy, and Permanent Neonatal Diabetes Syndrome-1), a severe condition leading to early childhood mortality. The small endoplasmic reticulum (ER)-membrane protein IER3IP1 plays a non-essential role in ER-Golgi transport. Here, we employed secretome and cell-surface proteomics to demonstrate that the absence of IER3IP1 or the presence of the pathogenic p.L78P mutation results in the retention of specific cell-surface receptors and secreted proteins crucial for neuronal migration within the ER. This phenomenon correlates with the distension of ER membranes and increased lysosomal activity. Notably, the trafficking of cargo receptor ERGIC53 and KDEL-receptor 2 is compromised, with the latter leading to the anomalous secretion of ER-localized chaperones. Our investigation extended to in-utero knock-down ofIer3ip1in mouse embryo brains, revealing a morphological phenotype in newborn neurons. In summary, our findings provide insights into how the loss or mutation of a 10 kDa small ER-membrane protein can cause a fatal syndrome.
Attosecond x-ray free-electron lasers utilizing an optical undulator in a self-selection regime
Authors: Xu Xinlu , Liu Jiaxin , Dalichaouch Thamine , Tsung Frank S. , Zhang Zhen , Huang Zhirong , Hogan Mark J. , Yan Xueqing , Joshi Chan , Mori Warren B.
Published: January 2024

Accelerator-based x-ray free-electron lasers (XFELs) are the latest addition to the revolutionary tools of discovery for the 21st century. The two major components of an XFEL are an accelerator-produced electron beam and a magnetic undulator, which tend to be kilometer-scale long and expensive. A proof-of-principle demonstration of free-electron lasing at 27 nm using beams from compact laser wakefield accelerators was shown recently by using a magnetic undulator. However, scaling these concepts to x-ray wavelengths is far from straightforward as the requirements on the beam quality and jitters become much more stringent. Here, we present an ultracompact scheme to produce tens of attosecond x-ray pulses with several GW peak power utilizing a novel aspect of the FEL instability using a highly chirped, prebunched, and ultrabright tens of MeV electron beam from a plasma-based accelerator interacting with an optical undulator. The FEL resonant relation between the prebunched period and the energy selects resonant electrons automatically from the highly chirped beam which leads to a stable generation of attosecond x-ray pulses. Furthermore, two-color attosecond pulses with subfemtosecond separation can be produced by adjusting the energy distribution of the electron beam so that multiple FEL resonances occur at different locations within the beam. Such a tunable coherent attosecond x-ray sources may open up a new area of attosecond science enabled by x-ray attosecond pump/probe techniques.

Published by the American Physical Society
2024
Numerical modeling of a proof-of-principle experiment on optical stochastic cooling at an electron storage ring
Authors: Dick A. J. , Borland M. , Jarvis J. , Lebedev V. , Piot P. , Romanov A. , Wallbank M.
Published: January 2024

Cooling of beams circulating in storage rings is critical for many applications including particle colliders and synchrotron light sources. A method enabling unprecedented beam-cooling rates, optical stochastic cooling (OSC), was recently demonstrated in the Integrable Optics Test Accelerator (IOTA) electron storage ring at Fermilab [J. Jarvis , ]. This paper describes the numerical implementation of the OSC process in the particle-tracking program and discusses the validation of the developed model with available experimental data. The model is also employed to highlight some features associated with different modes of operation of OSC. The developed simulation tool should be valuable in guiding future configurations of optical stochastic cooling and, more broadly, modeling self-field-based beam manipulations.

Published by the American Physical Society
2024
Proof-of-principle
e+
source for future colliders
Authors: Vallis N. , Craievich P. , Schär M. , Zennaro R. , Auchmann B. , Braun H. H. , Besana M. I. , Duda M. , Fortunati R. , Garcia-Rodrigues H. , Hauenstein D. , Ischebeck R. , Ismaili E. , Juranić P. , Kosse J. , Magazinik A. , Marcellini F. , Michlmayr T. , Müller S. , Pedrozzi M. , Rotundo R. , Orlandi G. L. , Seidel M. , Strohmaier N. , Zykova M.
Published: January 2024

The PSI Positron Production (P3 or P-cubed) experiment is a e+ source and capture system with the potential to increase by an order of magnitude the state-of-the-art e+ yield normalized to the drive linac energy, a highly desirable goal for future colliders. The experiment is framed in the FCC-ee injector study and will be hosted at SwissFEL, located at the Paul Scherrer Institute in Switzerland. This paper presents the P3 project at an advanced stage, with an emphasis on a capture system featuring a novel e+ matching device based on high-temperature superconducting solenoids, followed by two large aperture rf cavities surrounded by normal-conducting solenoids. The diagnostics design is also introduced, including monitors of charge, energy spectrum, and bunch-by-bunch longitudinal profile simultaneously for secondary e+ and e−. The last chapter of the text overviews the currently ongoing installation at SwissFEL, including the beam transfer line, rf network, radiation protection, and other relevant activities toward the operation with e+ in the coming years.

Published by the American Physical Society
2024
Proton’s gluon GPDs at large skewness and gravitational form factors from near threshold heavy quarkonium photoproduction
Authors: Guo Yuxun , Ji Xiangdong , Yuan Feng
Published: January 2024

We study the exclusive near threshold photoproduction of heavy quarkonium in the framework of the generalized parton distribution (GPD) factorization, taking the J/ψ production as an example. Because of the threshold kinematics, the Compton-like amplitudes are related to gluon GPDs at large skewness ξ, distinct from the common kinematics in asymptotic high energy where the skewness is typically small. We discuss the nature of large-ξ expansion of these amplitudes in terms of the moments of gluon GPDs in the large-ξ limit. Based on that, we propose several ways to extract the first few moments of the gluon GPDs from these amplitudes, with the leading ones corresponding to the gluonic gravitational or energy-momentum tensor form factors (GFFs). We apply these methods to analyze the recent near threshold J/ψ production measurements by the J/ψ 007 experiment and GlueX Collaboration and find that the ξ scaling of the measured differential cross sections is consistent with the asymptotic behavior. However, the current data are not accurate enough yet for a complete determination of the gluonic GFFs, and therefore we consider some prospects for better extractions in the future.

Published by the American Physical Society
2024
Algebraic model to study the internal structure of pseudoscalar mesons with heavy-light quark content
Authors: Almeida-Zamora B. , Cobos-Martínez J. J. , Bashir A. , Raya K. , Rodríguez-Quintero J. , Segovia J.
Published: January 2024

The internal structure of all lowest-lying pseudoscalar mesons with heavy-light quark content is studied in detail using an algebraic model that has been applied recently, and successfully, to the same physical observables of pseudoscalar and vector mesons with hidden-flavor quark content, from light to heavy quark sectors. The algebraic model consists on constructing simple and evidence-based of the meson’s Bethe-Salpeter amplitude (BSA) and quark’s propagator in such a way that the Bethe-Salpeter wave function (BSWF) can then be readily computed algebraically. Its subsequent projection onto the light front yields the light front wave function (LFWF) whose form allows us a simple access to the valence-quark parton distribution amplitude (PDA) by integrating over the transverse momentum squared. We exploit our current knowledge of the PDAs of lowest-lying pseudoscalar heavy-light mesons to compute their generalized parton distributions (GPDs) through the overlap representation of LFWFs. From these three dimensional knowledge, different limits/projections lead us to deduce the related parton distribution functions (PDFs), electromagnetic form factors (EFFs), and impact parameter space GPDs (IPS-GPDs). When possible, we make explicit comparisons with available experimental results and earlier theoretical predictions.

Published by the American Physical Society
2024
Manifestly covariant variational principle for gauge theories of gravity
Authors: Hobson M. P. , Lasenby A. N. , Barker W. E. V.
Published: January 2024

A variational principle for gauge theories of gravity is presented, which maintains manifest covariance under the symmetries to which the action is invariant, throughout the calculation of the equations of motion and conservation laws. This is performed by deriving explicit manifestly covariant expressions for the Euler-Lagrange variational derivatives and Noether’s theorems for a generic action of the form typically assumed in gauge theories of gravity. The approach is illustrated by application to two scale-invariant gravitational gauge theories, namely Weyl gauge theory (WGT) and the recently proposed ‘extended’ Weyl gauge theory (eWGT), where the latter may be considered as a novel gauging of the conformal group; the method can also be straightforwardly applied to other theories with smaller or larger symmetry groups. In addition, the approach enables one easily to establish the relationship between manifestly covariant forms of variational derivatives obtained when one or more of the gauge field strengths is set to zero either before or after the variation is performed. This is illustrated explicitly for both WGT and eWGT in the case where the translational gauge field strength (or torsion) is set to zero before and after performing the variation, respectively.

Published by the American Physical Society
2024
Soft graviton exchange and the information paradox
Authors: Gaddam Nava , Groenenboom Nico
Published: January 2024

We show that there is a remarkable phase in quantum gravity where gravitational scattering amplitudes mediated by virtual gravitons can be calculated explicitly in effective field theory, when the impact parameter b satisfies LPl≪b≲RS, with RS being the Schwarzschild radius. This phase captures collisions with energies satisfying s≫γMPl (with γ∼MPl/MBH) near the horizon. We call this the black hole eikonal phase, in contrast to its flat space analog where collisions are trans-Planckian. Hawking’s geometric optics approximation neglects gravitational interactions near the horizon, and results in thermal occupation numbers in the Bogoliubov coefficients. We show that these interactions are mediated by graviton exchange in 2→2 scattering near the horizon, and explicitly calculate the S-matrix nonperturbatively in

M

Pl

/

M

BH

. This involves a resummation of infinitely many ladder diagrams near the horizon, all mediated by virtual soft gravitons. The S-matrix turns out to be a pure phase upon this resummation and is agnostic of Planckian physics and any specific ultraviolet completion. In contrast to the flat-space eikonal limit, the black hole eikonal phase captures collisions of extremely low energy near the horizon.

Published by the American Physical Society
2024
Anisotropy-assisted magnon condensation in ferromagnetic thin films
Authors: Frostad Therese , Pirro Philipp , Serga Alexander A. , Hillebrands Burkard , Brataas Arne , Qaiumzadeh Alireza
Published: January 2024

We theoretically demonstrate that adding an easy-axis magnetic anisotropy facilitates magnon condensation in thin yttrium iron garnet (YIG) films. Dipolar interactions in a quasi-equilibrium state stabilize room-temperature magnon condensation in YIG. Even though the out-of-plane easy-axis anisotropy generally competes with the dipolar interactions, we show that adding such magnetic anisotropy may even assist the generation of the magnon condensate electrically via the spin-transfer torque mechanism. We use analytical calculations and micromagnetic simulations to illustrate this effect. Our results may explain the recent experiment on Bi-doped YIG and open a pathway toward applying current-driven magnon condensation in quantum spintronics.

Published by the American Physical Society
2024
Screw dislocation dynamics in confinement-induced layering of Yukawa liquids after quenching
Authors: Zhang Yun-Xuan , Hu Hao-Wei , Zhao Yi-Cheng , I Lin
Published: January 2024

Screw dislocation filaments (SDFs) with undefined phases and winded around by helical isophase fronts are fundamental topological defects, which can be used for characterizing the disorder of layered solids and unstable traveling waves. Here, we numerically demonstrate the observation of fluctuating SDFs in the transient relaxation of confinement-induced layering of Yukawa liquids after quenching. We classify the generic dynamical behaviors of screw dislocations (SDs) and unravel their topological origins, which are elusive fundamental issues for general layered systems. It is found that the spatiotemporal growth and decay of layer undulation instability causing sequential rupture and reconnection of a stack of layers are the keys for the formation of SD loops or strings of connected SDFs with alternating helicities, and their spatiotemporal fluctuations. The breaking and reconnection of two approaching SDFs with opposite or the same helicities can form two new separated SDFs. This causes an SD loop to be shed from or merged with another SD loop. The total number of SDs decreases and levels off with increasing time from quenching.

Published by the American Physical Society
2024
Corporate engagement with start-ups (CEWS): a systematic review of literature and future research agenda
Authors: Jha Sonika , Singh Anil Kumar , Basu Sriparna
Published: January 2024

Purpose

The purpose of this paper is to provide a systematic review of literature on corporate engagement with start-ups (CEWS) by identifying the modes, contexts, antecedents, barriers and outcomes. As an emerging field, CEWS presently has no such review available which will help in building consensus within the field and shape future research directions.

Design/methodology/approach

The study followed a two-phased systematic review of literature. Three research databases (i.e. Web of Science, ScienceDirect and SCOPUS) were accessed to gather and conduct the review. Of the total 379 papers retrieved, 63 total relevant papers were studied and analysed. The exhaustive review of literature helped to uncover the contexts, perspectives, antecedents, outcomes and barriers reported across the different modes of CEWS.

Findings

The study highlighted the five prominent modes of CEWS favoured by large corporations and start-ups. It found that the large corporations and start-ups associate with one another on the basis of complementarities of activities, resources and motives to pursue their strategic orientations. The engagements also face barriers on the ground, such as incompatibility of goals, power imbalances, cultural differences and weak engagement plans. Most important contexts seen were the high-technology industries in the developed economies like the USA and Europe. It also found that ecosystem creation, accessing innovation and corporate strategy have been preferred as the most productive modes of CEWS in the literature.

Practical implications

This review provides practitioners with a detailed list of the modes and drivers of CEWS. Subsequently, the barriers that need to be managed to successfully execute a specific mode of engagement. This shall enable the practitioners in developing and adopting the best practices while engaging with the start-ups to better facilitate the outcomes of CEWS.

Originality/value

To the best of the authors’ knowledge, there is no systematic literature review available in the domain of CEWS – thus, this study makes an important methodological contribution to the field. By consolidating the fragmented yet growing knowledge on CEWS, the study presents a detailed understanding of what drives and obstructs the engagement between large corporations and start-ups.
Application of marketing to reduce consumer food waste in restaurants
Authors: Lee Daisy , Wan Calvin , Leung Tiffany Cheng Han , Rundle-Thiele Sharyn , Li Gabriel
Published: January 2024

Purpose

This paper aims to illustrate the application and effectiveness of a marketing programme co-designed by supply- and demand-side stakeholders to reduce consumer food waste in restaurants.

Design/methodology/approach

This stakeholder-based marketing pilot study adopted the co-create, build and engage framework for programme design and implementation. Major stakeholders, interacting at the point-of-sale, participated in a series of focus groups, interviews and co-design. The research process informed the marketing mix, which aimed to provide value for all parties. The four-week pilot programme was delivered in a non-buffet-style commercial restaurant chain for 10 months. The amount of consumer food leftovers was measured and compared with pre-programme baseline data to evaluate programme effectiveness.

Findings

The results show that the marketing mix co-designed by restaurant stakeholders and consumers effectively reduced food waste by almost half in the pilot period. The profitability of the pilot restaurant increased as food costs decreased.

Research limitations/implications

This research demonstrates how working with stakeholders from both the supply and demand sides can identify motivations and barriers. Insights gained in the research phase can inform the delivery of a marketing mix that reduces consumer food waste. This study demonstrates the marketing research, design, implementation and evaluation process for a marketing programme that reduced consumer food waste.

Practical implications

To effectively reduce consumer food waste, practitioners should not only focus on changing consumers’ behaviour. Co-designing solutions with food service stakeholders to address business and operation challenges is crucial to the attainment of a positive impact at the point-of-sale.

Originality/value

This research shows how marketing changes behaviour in individuals and business entities, contributing to positive environmental impact through waste reduction in the commercial food service sector.
Evaluating the impact of AI on insurance: the four emerging AI- and data-driven business models
Authors: Zarifis Alex , Holland Christopher P. , Milne Alistair
Published: January 2024

The increasing capabilities of artificial intelligence (AI) are changing the way organizations operate and interact with users both internally and externally. The insurance sector is currently using AI in several ways but its potential to disrupt insurance is not clear. This research evaluated the implementation of AI-led automation in 20 insurance companies. The findings indicate four business models (BM) emerging: In the first model the insurer takes a smaller part of the value chain allowing others with superior AI and data to take a larger part. In the second model the insurer keeps the same model and value chain but uses AI to improve effectiveness. In the third model the insurer adapts their model to fully utilize AI and seek new sources of data and customers. Lastly in the fourth model a technology focused company uses their existing AI prowess, superior data and extensive customer base, and adds insurance provision.
Designing industry 4.0 implementation from the initial background and context of companies
Authors: Rocchi Valérie , Brissaud Daniel
Published: January 2024

Industry 4.0 is a promising concept that allows industries to meet customers’ demands with flexible and resilient processes, and highly personalised products. This concept is made up of different dimensions. For a long time, innovative digital technology has been thought of as the only dimension to succeed in digital transformation projects. Other dimensions have been identified such as organisation, strategy, and human resources as key while rolling out digital technology in factories. From these findings, researchers have designed industry 4.0 theoretical models and then built readiness models that allow for analysing the gap between the company initial situation and the theoretical model. Nevertheless, this purely deductive approach does not take into consideration a company’s background and context, and eventually favours one single digital transformation model. This article aims at analysing four actual digital transformation projects and demonstrating that the digital transformation’s success or failure depends on the combination of two variables related to a company’s background and context. This research is based on a double approach: deductive and inductive. First, a literature review has been carried out to define industry 4.0 concept and its main dimensions and digital transformation success factors, as well as barriers, have been investigated. Second, a qualitative survey has been designed to study in-depth four actual industry digital transformation projects, their genesis as well as their execution, to analyse the key variables in succeeding or failing. 46 semi-structured interviews were carried out with projects’ members; interviews have been analysed with thematic content analysis. Then, each digital transformation project has been modelled regarding the key variables and analysed with regards to succeeding or failing. Investigated projects have consolidated the models of digital transformation. Finally, nine digital transformation types have been identified.
The challenge of tackling the obesity economic burden: the case of Uruguay
Authors: Kaufmann Ricardo , Pontet-Ubal Norma
Published: January 2024

The estimation of the burden of a disease is one of the tasks with the longest tradition in health economics, which allows us to know the volume of resources that a country allocates to a specific health problem, and to compare countries and diseases. Although the fundamental objective of health systems is not to reduce the cost of the disease, but to improve the health of the population, the studies of burden of disease establish the economic seriousness of the problem, orienting the priorities of action.

Government-funded medical expenditure in Uruguay for the last ten years has tripled in US dollars. The increase in the prevalence of overweight and obesity has contributed to this growth. According to the World Health Organization, Uruguay has the highest growing trend in the prevalence of both overweight and obesity in South America. We have previously estimated that economic burden linked to obesity will be more than US$500 million by 2020, a figure close to 1% of the country’s GDP.

In this study, we tried to generate a measure of value to ascertain the cost of inaction in the fight against obesity and its consequences linked to several non-communicable diseases. The cost of inaction is not defined as the cost of not doing, but as the cost of not implementing the right policies (in this case health prevention policies) at the right time.
Accepting the unacceptable? Exploring how acceptance relates to quality of life and death anxiety in a cancer population
Authors: Brabbins Lucinda , Moghaddam Nima , Dawson David
Published: January 2024

Background: Quality of life is a core concern for cancer patients, which can be negatively affected by illness-related death anxiety; yet understanding of how to appropriately target psycho-oncological interventions remains lacking. We aimed to explore experiential acceptance in cancer patients, and whether acceptance – as an alternative to avoidant coping – was related to and predictive of better quality of life and death anxiety outcomes.

Methods: We used a longitudinal, quantitative design with a follow-up after three months. Seventy-two participants completed a questionnaire-battery measuring illness appraisals, acceptance and non-acceptance coping-styles, quality of life, and death anxiety; 31 participants repeated the battery after three months.

Results: Acceptance was an independent explanatory and predictive variable for quality of life and death anxiety, in the direction of psychological health. Acceptance had greater explanatory power for outcomes than either cancer appraisals or avoidant response styles. Avoidant response styles were associated with greater death anxiety and poorer quality of life.

Conclusions: The findings support the role of an accepting response-style in favourable psychological outcomes, identifying a possible target for future psychological intervention. Response styles that might be encouraged in other therapies, such as active coping, planning, and positive reframing, were not associated with beneficial outcomes.
Violation of lockdown norms and peaks in daily number of positive cases to COVID-19 in Italy
Authors: Ruiu Gabriele , Ruiu Maria Laura
Published: January 2024

Italy has been the first Western Country to suffer a massive outbreak of COVID-19. Starting from the 11th of March 2020, the Italian Government approved a series of emergency restrictive measures to limit people’s movement and social contacts. The aim of this short paper is to test if the number of norm-violations (related to people’s movement) might contribute to the peaks of new COVID-19 positives after few days. We show that peaks in the violations of the lockdown norms correspond to peaks in new positive cases about 6 days later.
COVID-19 pandemic, psychological response to quarantine, and knowledge of the disease among inmates in a Nigerian custodial center
Authors: Okoro Johnson , Odionye Tobechukwu , Nweze Benedicta , Onuoha Martins , Ezeonwuka Chinenye , Owoh Jude , Nkire Joel
Published: January 2024

This was a cross-sectional study to assess the psychological response to quarantine during COVID-19 pandemic and knowledge level about the disease among inmates of a Custodial Center in Enugu, Nigeria. A total of 66 new prison inmates were assessed for psychological distress using the Kessler Psychological Distress Scale (K10); and inmates’ knowledge about COVID-19 using a COVID-19 Knowledge Questionnaire developed by the researchers.

Participants had a mean age of 28.39±8.71 years; 63 (95.5%) were male inmates and 3 (4.5%) were female inmates. Sixty-one (92.4%) were awaiting-trial inmates, 43 (65.1%) had psychological distress, and 35 (53%) had completed at least secondary school. COVID-19 questionnaire mean score was 3.82±3.33. Thirty-one (21.8%) had adequate knowledge of COVID-19 (7-10 score), while 35 (53%) and 10 (15.2%) had poor (0-3) and average (4-6) knowledge, respectively. Adequate COVID-19 knowledge level was significantly higher among those that completed at least secondary school (48.6%) than those who did not (12.9%). Though not statistically significant, adequate COVID-19 knowledge level was commoner among those without psychological distress (43.5%) than those with psychological distress (25.6%).

Considering responses to specific questions contained in the questionnaire, knowledge about some questions was relatively high. For example, a majority of the participants 45 (68.2%) correctly responded that death can be a complication of COVID-19; whereas half of them 33 (50%) correctly responded that regular hand washing with soap and water can help prevent the spread of the disease. Nevertheless, responses to some questions showed poor knowledge about the disease as 18 (27.3%) correctly answered that COVID-19 can affect the lungs, while 20 (30.3%) correctly responded that COVID-19 is caused by a virus.

Our study highlighted the need to have all quarantined persons educated about the disease for which they are being quarantined. It also provided the opportunity to raise awareness of COVD-19 among the inmates.
COVID-19 and the role of health promoters and educators
Authors: Woodall James
Published: January 2024

The role of health promoters and educators in the current and future response to COVID-19 is critical, but, to date, under explored. This opinion paper offers a number of important contributions that this professional group may offer both in the immediate and future strategy of global public health. While the importance of a medical model of health cannot be underplayed, the social model of health suggests that some groups in society are being more disproportionately impacted than others. Health promotion has been committed to reducing inequalities and therefore offers “a voice” to those most marginalised. The paper suggests that bottom-up approaches focusing on building individual and community control is essential and, moreover, the concepts of a settings approach in health promotion, the fostering of critical health literacy and “salutogenesis” may be worthy of further debate and discussion.
Recognition of symptoms, mitigating mechanisms and self-care experiences of type 2 diabetes patients receiving insulin treatment in North-East Ethiopia
Authors: Mekashaw Bayked Ewunetie , Demeke Workneh Birhanu , Haile Kahissay Mesfin
Published: January 2024

Background: Compliance of patients with self-care practices is the mainstay of measures to manage diabetes. This study explored self-care practices of type 2 diabetes patients receiving insulin treatment in North-East Ethiopia.

Methods: The study employed an interpretive phenomenological approach using purposive sampling. The data were collected from 24 (11 males and 13 females) participants (July 2019 to January 2020) using in-depth interviews till theoretical saturation. The data were analyzed thematically and organized using QDA Miner Lite v2.0.8.

Results: The findings were categorized into: labeling diabetes, self-care maintenance experiences, recognition of symptoms, and mitigating mechanisms. The self-care maintenance practice of patients was linked with diet input preferences and the effectiveness level of insulin. What guides the self-care behavior was the patients’ preferentiality of strictly adhering to their preferred dietary inputs. Barley and wheat were the most common preferential and non-preferential inputs, respectively. The patients strictly adhered to insulin treatment because they found it effective. The most common hyperglycemia symptoms to be managed by taking an additional dose of insulin, were frequent urination, increased thirst, and their consequence (dehydration). Excessive sweating (initial), shivering (middle), and falling (final), respectively in severity, were the most common symptoms of hypoglycemia which were perceived to be treated with sweet snacks.

Originality: To our knowledge, this is the first research in Ethiopia to investigate the self-care experiences of type 2 diabetes patients receiving insulin using an interpretive phenomenological approach.
The mediation effect of blood production on the relationship between master production scheduling and transfusion sustainability in Uganda
Authors: Kaconco James , Nabuuma Betty , Mugarura Jude Thaddeo
Published: January 2024

Background: This paper examines the relationship between determinants of blood transfusion sustainability (BTS) that is master production scheduling (MPS) and blood production (BP) of Uganda. The study was founded on four objectives. The study looked at the direct relationship between MPS and the BTS, direct relationship between MPS and BP, direct relationship between BP and BTS. It also assessed how BP mediated the direct relationship between MPS and BTS. The study used a quantitative method.

Methods: A survey questionnaire was administered to collect data from 367 staff of regional blood banks and government university teaching hospital blood banks; and 213 were found to be usable. The main analysis was done using structural equation modeling.

Results: This study found that MPS had a negative and insignificant relationship with the BTS. The study found that relationship between MPS and BP was positive and significant. The study also found that relationship between BP and BTS was positive and significant. The study concluded that the effect of MPS on BTS was fully mediated by BP. It was recommended that blood banks seeking to achieve transfusion sustainability must understand the sector in which they operate. The various stakeholders in the blood supply chain ie blood banks, hospital blood banks, funding agents, ministry of health, must also integrate to enhance the transfusion sustainability. Blood banks performance measures essentially timely delivery was very critical for saving lives of patients in need of blood.

Conclusion: The study has provided a new conceptual framework that investigate the BP mediating effect on the relationship of MPS and BTS, and thus can serve as an incentive for more research to be conducted in this regard of different developing countries. The authors also proposed identifying the effect of other BP factors such as blood donor management and hospital transfusion practices on BTS.
Exploring the current context for professional learning networks, the conditions for their success, and research needs moving forwards
Authors: Brown Chris
Published: January 2024

The emergence of networks within education has been driven by a number of factors, including: the complex nature of the issues facing education, which are typically too great for single schools to tackle by themselves; changes to educational governance structures, which involve the hollowing out of the middle tier and the introduction of new approaches with an individualized focus; in addition is the increased emphasis on education systems that are “self-improving and school-led”. Within this context, the realization of teacher and school improvement actively emerges from establishing cultures of enquiry and learning, both within and across schools. Since not every teacher in a school can collaboratively learn with every other teacher in a network, the most efficient formation of networks will comprise small numbers of teachers learning on behalf of others.

Within this context, Professional Learning Networks (PLNs) are defined as any group who engage in collaborative learning with others outside of their everyday community of practice; with the ultimate aim of PLN activity being to improve outcomes for children. Research suggests that the use of PLNs can be effective in supporting school improvement. In addition, PLNs are an effective way to enable schools to collaborate to improve educational provision in disadvantaged areas. Nonetheless harnessing the benefits of PLNs is not without challenge. In response, this paper explores the notion of PLNs in detail; it also sheds light on the key factors and conditions that need to be present if PLNs are to lead to sustained improvements in teaching and learning. In particular, the paper explores the role of school leaders in creating meaningful two-way links between PLNs and their schools, in order to ensure that both teachers and students benefit from the collaborative learning activity that PLNs foster. The paper concludes by suggesting possible future research in this area.
Challenges in developing university–industry relationship: quantitative evidence from higher education institutions in the UAE
Authors: Singh Abhilasha
Published: January 2024

Background and objective: The lack of human and intellectual resources and capital has affected the survival of different industries and organizations in this globally competitive world. Universities have failed to provide necessary human resources to these organizations. The coordination between industries and universities is not optimal. Such challenges are being faced in the United Arab Emirates (UAE); therefore, there is a need to investigate the reasons behind these challenges to develop an ideal university-industry relationship in UAE. The present study aims to evaluate the missing links in the relationships between universities and industries of UAE.

Methods: A quantitative research design has been used to recruit 100 department heads and senior professors from 20 public and private universities in the UAE. Descriptive statistics, regression analysis and factor analysis have been used to analyze the data collected through SPSS v.20.

Results: The results have shown a significant and positive impact of intellectual property (IP) policies (p=0.045) and scientific knowledge (p=0.023) on knowledge transfer; IP policies (p=0.067), shared governance (p=0.018) and scientific knowledge (p=0.017) on trust; IP policies (p=0.069), shared governance (p=0.034) and scientific knowledge (p=0.018) on innovation performance.

Conclusion: The findings have suggested that the role of interorganizational governance mechanisms is important in university industry collaborations to increase trust, innovation, and shared governance.
Impact by design: planning your research impact in 7Cs
Authors: Sreenan Niall , Hinrichs-Krapels Saba , Pollitt Alexandra , Rawlings Sarah , Grant Jonathan , Wilkinson Benedict , Pow Ross , Kinloch Emma
Published: January 2024

Although supporting and assessing the non-academic “impact” of research are not entirely new developments in higher education, academics and research institutions are under increasing pressure to produce work that has a measurable influence outside the academy. With a view to supporting the solution of complex societal issues with evidence and expertise, and against the background of increased emphasis on impact in the United Kingdom's 2021 Research Excellence Framework (REF2021) and a proliferation of impact guides and tools, this article offers a simple, easy to remember framework for designing impactful research. We call this framework “The 7Cs of Impact” – Context, Communities, Constituencies, Challenge, Channels, Communication and Capture.

Drawing on core elements of the Policy Institute at King's College London's Impact by Design training course and the authors' practical experience in supporting and delivering impact, this paper outlines how this framework can help address key aspects across the lifecycle of a research project and plan, from identifying the intended impact of research and writing it into grants and proposals, to engaging project stakeholders and assessing whether the project has had the desired impact.

While preparations for current and future REF submissions may benefit from using this framework, this paper sets out the “7Cs” with a more holistic view of impact in mind, seeking to aid researchers in identifying, capturing, and communicating how research projects can and do contribute to the improvement in society.
Rise in higher education researchers and academic publications
Authors: To W.M. , Yu Billy T.W.
Published: January 2024

Background: How many higher education researchers are there in the world? How many academic articles are published by researchers each year? This paper aims to answer these two questions by tracking the number of higher education teachers and the number of publications over the past four decades.

Methods: We collected data on the number of higher education institutions and researchers from the United Nations, the World Bank, and the US, China, and UK governments (three countries with the largest number of academic publications in recent years). We used Scopus to obtain the number of publications per year. The growth of higher education researchers and academic publications were characterized using 4-parameter logistic models.

Results: The number of higher education teachers-cum-researchers increased from 4 million in 1980 to 13.1 million in 2018 worldwide. Concurrently, the number of academic publications increased from 0.65 million in 1980 to 3.16 million in 2018 based on data from Scopus. At the country level, the number of academic publications from the USA increased from 0.15 million in 1980 to 0.70 million in 2018, while that from China increased by almost 1,000 times from 629 in 1980 to 0.60 million in 2018.

Conclusions: The number of higher education researchers would reach 13.6 million and they would publish 3.21 million academic articles in 2020, imposing enormous pressure to publishers, peer-reviewers, and people who want to understand emerging scientific development. Additionally, not all academic publications are easily assessable because most articles are behind pay-walls. In addition, unethical research practices including falsification, fabrication, plagiarism, slicing publication, publication in a predatory journal or conference, etc. may hinder scientific and human development.
Demographic factors, attitude and knowledge of persons with special needs towards COVID-19 in Nigeria: implications for counselling and social policy
Authors: Lazarus Kelechi Uchemadu , Oluwole David Adebayo
Published: January 2024

This study investigated demographic factors, attitude and knowledge of persons with special needs towards COVID-19 in Nigeria between 12 May and 25 May 2020. This cross-sectional online survey was conducted among 72 persons with special needs purposively selected from the six geo-political zones in Nigeria. A questionnaire comprising questions on demographic information (three), knowledge (24) and attitude (28) towards COVID-19 was completed via Google forms by the participants (r=0.78). There were more males (51, 70.8%) than females (21, 29.2%) and the most common age group was 34-44 years (37.5%). The number of participants with a hearing impairment was 34 (47.2%) and the number with a visual impairment was 26 (36.1%). The results indicate adequate knowledge about the characteristics of COVID-19. It was found that 98.6% of the participants had heard about COVID-19; 94.4% were aware that COVID-19 is a contagious disease, 91.7% stated that COVID-19 is a virus and 88.9% reported correctly that the incubation period is 3-14 days. The knowledge about symptoms of COVID-19 among participants was high (x=2.63; participants obtained 87.8% of the total achievable score for these questions). The knowledge about prevention and control of COVID-19 among participants needs was very high (x=2.77; participants obtained 92.3% of the total achievable score for these questions). Attitude of participants towards the COVID-19 outbreak was positive and above average (x=2.84). However, participants reported that it is hard to get palliatives or financial support from others during COVID-19 lockdown (52.8%) and that they feel frustrated by the uncaring attitude of the government towards them during COVID-19 lockdown (55.6%). On this basis, counselling and social policy implications were suggested including the provision of palliatives by the government and the need for widespread enlightenment among individuals with special needs on prevention of COVID-19.
Secondary school teachers' perception of quality management practices in Ethiopia: implications for quality education for all
Authors: Alemu Aklilu
Published: January 2024

Background: Most children in low-income countries complete their elementary education with low competency in essential reading, writing, and arithmetic skills. Besides, about 250 million students are not learning the basics, most of whom have spent at least four years in school, and this failure is coined the global learning crisis. This study aimed to examine educational quality management practices perceived by secondary school teachers.

Methods: The study employed a multilevel mixed-method design. Employing a simple random sampling technique, the researcher selected 251 teachers from 10 secondary schools in the research regions. He collected data through a researcher-designed questionnaire, school standards, and student achievement records from November 2018 to March 2019. He analyzed data from a questionnaire using frequency, percentage, mean, Pearson correlation, and exploratory factor analysis. The document review concerning quality management was analyzed using content analysis to triangulate the quantitative findings.

Results: At the school level, the study revealed the impracticality of laboratories. Besides, incompetent and unmotivated teachers and students ran the education business from the input side. At the same level, principals' management practices on staff development and encouraging parents to support their schools were low. The principals' management practices in the teaching-learning process were also undesirable at the classroom level. Overall, the study revealed incredibly insufficient input, process, and output management in the study context.

Conclusion: Hence, the study concluded that it is difficult to achieve the very objectives of producing creative, critical, and problem-solving individuals through this type of educational provision and its management. Due to this, it is not easy to achieve quality education for all goals.
Experiences and perspectives regarding challenge-based learning in online sustainability education
Authors: Kasch Julia , Bootsma Margien , Schutjens Veronique , van Dam Frans , Kirkels Arjan , Prins Frans , Rebel Karin
Published: January 2024

In this opinion article, the authors share their experiences with and perspectives on course design requirements and barriers when applying challenge-based learning (CBL) in an online sustainability education setting. CBL is an established learning approach for (higher) sustainability education. It enables teachers to engage students with open, real-life grand challenges through inter-/transdisciplinary student team collaboration. However, empirical research is scarce and mainly based on face-to-face CBL case studies. Thus far, the opportunities to apply CBL in online educational settings are also underinvestigated.

Using the TPACK framework, the authors address technological, pedagogical and content knowledge related to CBL and online sustainability education. The integration of the different components is discussed, providing teachers and course designers insight into design requirements and barriers.

This paper supports the promising future of online CBL for sustainability education, especially in the context of inter-/national inter-university collaboration, yet emphasizes the need for deliberate use of online collaboration and teaching tools.
Graduate employability in Ghana: embedding social enterprise skills within the higher education framework
Authors: Winful Ernest Christian , Snowden Michael , Halsall Jamie P. , Quaye Josiah Nii Adu , Hyams-Ssekasi Denis , Opuni Frank Frimpong , Afriyie Emelia Ohene , Ocloo Elikem Chosniel , Opoku-Asante Kofi
Published: January 2024

Levels of unemployment and environmental challenges make social entrepreneurship and social enterprise very important for the sustainability of society. Higher education has played a fundamental role in driving entrepreneurship and innovation in local, national, regional, and global contexts. The authors of this article explore the state of the legislative framework in Ghana, as well as social enterprise education, stakeholder engagement, models and challenges. The methodology applied for this paper is concept mapping, enabling the critical exploration of the relevance of social enterprise in the context of higher education, and demonstrating how it could practically serve as a panacea to rising youth unemployment. This research concludes by making a case for including social enterprise in the higher education curriculum.