bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of quality of life and psychoemotional state of patients with psoriasis against the background of standard medicamentous therapy and the differentiated photochromotherapy use
Authors: Petrova E. V. , Kir'yanova V. V. , Egorova Yu. S. , Tsyganova O. D. , Mar'yekha G. L. , Gurkovskaya Ya. Yu. , Smirnova N. V. , Petrov D. A.
Published: April 2021

Background. Psoriasis is a systemic disease with the presence of comorbid pathology, which is the cause of serious psychological problems.
The aim of the study was to assess the quality of life and psychoemotional status of patients with psoriasis against the background of standard drug therapy with the inclusion of photochromotherapy (PCT).
Methods. The randomized controlled study included 144 patients (mean age 48.34 13.51 years) with psoriasis in the advanced stage. Patients, depending on the method of treatment, were divided into 4 groups, comparable by clinical and functional characteristics. For all groups, standard drug treatment was prescribed, including antiinflammatory, hyposensitizing, detoxification and external therapy, while additionally for 10 days, patients of the 2nd group (n = 47) received PCT with narrow-band optical radiation (NOR) 540 nm, patients of the 3rd group (n = 48) PCT with NOR 650 nm, patients of the 4th group (n = 21) imitation of PCT (placebo). Patients of the 1st group (n = 28) received only standard treatment.
Results. The positive effect of NOR 540 nm on the psychoemotional state and NOR 650 nm on the quality of life of patients with psoriasis has been demonstrated.
Conclusion. Thus, taking into account the significant positive effect of green radiation (NOR 540 nm) on the indicators of the psychoemotional state of patients with psoriasis in the advanced stage and the positive effect of red radiation (NOR 650 nm) on the indices of integral dermatological index of quality of life (improving the quality of life), NOR with these wavelengths can be recommended in the complex therapy of patients with exacerbation of psoriasis to increase the overall effectiveness of treatment.
Assessment of safety of influence of radiation of lengths of waves of 410, 580, and 630 nanometers for skin and a mucous membrane
Authors: Kholupova L. S. , Surkichin S. I.
Published: April 2021

Background. The safety effects of individual emission spectra of visible light are currently not well understood. Based on the above works, one can only indirectly judge the presence or absence of an adverse effect of the selected spectrum during mototherapy.
Aims: in our work, the goal was to detect the presence of a negative effect of certain wavelengths (410 nm, 580 nm and 630 nm) during mono-exposure to mucous membranes and skin.
Methods. At the first stage, the effect of radiation with wavelengths of 410 nm and 630 nm on the mucous membrane of the oral cavity of laboratory animals was determined. At the second stage of the study, 30 women aged 3545 years with signs of photodamage of the skin took part.
Results. No undesirable consequences were recorded either immediately after the procedure, or after 20 days. The results of histological examination at all stages of the study indicated the absence of pathological changes.
Conclusions. The results showed that mono-exposure with wavelengths of 410 nm, 580 nm and 630 nm is safe and can be recommended for further study and practical application.
Evaluation of the effectiveness of the use of osteоpathic methods of treatment of patients with chronic stone-free cholecystitis
Authors: Pankov O. A. , Matvienko V. V. , Frolkov V. K. , Zhernov V. A. , Zubarkina M. M.
Published: April 2021

Background. Osteopathic methods are used in practical medicine, but there is little scientific research in this area, especially in the treatment of somatic diseases.
The purpose of the research is to evaluate the effectiveness of osteopathy in the complex therapy of patients with chronic stone-free cholecystitis from the point of view of evidence-based medicine.
Methods. The study involved 114 patients who were divided into two groups, the control group and the main group, in which osteopathic procedures were applied. The functions of the gallbladder, bile and blood biochemistry, and cholecystokinin secretion were analyzed.
Results. It was found that osteopathic methods significantly increased the effectiveness of standard therapy both in terms of regression of clinical symptoms of the disease and in the functioning of the gallbladder. It is proved that the main group of patients significantly increases the secretion of cholecystokinin, which correlates with an improvement in the biochemistry of bile and its allocation. It was found that the effectiveness of osteopathic treatment methods does not depend on the gender of patients.
Conclusion. The results of the study indicate a fairly pronounced therapeutic effect of osteopathic procedures in the complex therapy of patients with chronic stone-free cholecystitis. The increase in the secretion of cholecystokinin is difficult to explain from the point of view of correction of functional blocks, and this problem remains the subject of further research.
General principles of diagnostic and conservative treatment of idiopathic scoliosis
Authors: Zaytseva T. N.
Published: April 2021

Scoliosis is an orthopedic disease characterized by complex multi-plane deformation of the spinal column and chest, accompanied by a violation of the functions of organs and systems of the body, which is the cause of severe physical and psychological suffering in children. It is very important to carry out effective conservative treatment of scoliosis in I and II severity to prevent further progression of spinal deformity. It is proved that physical treatment methods are required in the complex treatment of patients with scoliosis. The purpose of physiotherapy is to eliminate dystrophy, improve contractile function of the muscles of the back and abdomen, eliminate instability of the spine and reduce pain.
The evaluation of functional abilities of patients with osteoporotic vertebral fractures as a basis for rehabilitation programs developing
Authors: Marchenkova L. A. , Makarova E. V. , Eryomushkin M. A. , Герасименко M. Yu. , Styazkina E. M. , Chesnikova E. I.
Published: April 2021

Background.Due to the demand for special rehabilitation programs for patients with osteoporotic vertebral fractures (VFs), it is of interest to study the functional abilities of those patients. The scientific hypothesis suggests that osteoporotic VFs would cause muscle weakness, muscle dysfunction and conditional (basic motor) disturbances.
Objective:to estimate muscle strength, motor function and coordination disorders in patients with VFs in the setting of systemic osteoporosis as a basis for rehabilitation programs developing.
Methods. 120 patients aged 4380 with primary osteoporosis were enrolled. Study group comprised of 60 subjects (56 women, 4 men) with at least 1 VF confirmed by X-ray. Control group included 60 subjects (56 women, 4 men) with osteoporosis but without any osteoporotic fracture. The examination program consist of back muscles tenzodynamometry, balance tests and stabilometry.
Results. Muscle strength deficiency was estimated in study group in trunk flexors (TF) 40.9% and in trunk extensors (TE) 18.1% with an adequate function of the left lateral flexors (LLF) and in right lateral flexors (RLF). Patients with VFs had the lower muscle strength vs controls of TE (15.64 9.8 vs 27.73 9.9 kg, p = 0.00002), TF (14.61 8.98 vs 21.28 8.38 kg, p = 0.0006), LLF (13.10 7.2 vs 24.06 8.9 kg, p = 0.005) and RLF 13.44 7.43 vs 24.26 7.65 kg, p = 0.0003). Patients with VFs lose their balance faster during one-leg-standing test with open eyes (5.0 [1.0;10.0]vs 7.5 [5.0;10.5]sec in control group, p=0.03) and with closed eyes (2.0[0;3.0] vs 3.5[3.0;5.0]sec, p = 0.04). Fukuda-Unterberger test showed greater side dislocation in study group 40 [25;45]vs controls 30 [10; 45], (p=0.02). According to stabilometry study group was characterized vs control group by lower balance coefficient with open eyes (77.27.6 vs 85.79.4%, p=0.002) and with closed eyes (67.19.8 vs 73.49.9%, p=0.03), greater sagittal displacement(6.8 [2.1;37.7]vs4.8 [1.8;10.7]mm, p=0.025) and deviation in the saggital plane(1.2 [-1.07;1.5]vs-1.2 [-1.5;1.2]mm, p = 0.01), and also less pressure center velocity (9.51 4.4 vs 7.1 2.7 mm/sec, р=0.009).
Conclusions.VFs in osteoporotic patients are associated with reduction of trunk muscles strength and negatively affect static and dynamic balance function. The obtained data should be taken into account when developing rehabilitation programs for patients with osteoporosis who have suffered compression VFs.
Vibrotherapy in medical practice
Authors: Kir'yanova V. V. , Gerasimenko M. Yu. , Shorokhova M. N. , Gorbacheva K. V.
Published: April 2021

A review of literature sources on the use of vibrotherapy in physiotherapy is presented. In the mechanism of action of vibrotherapy, the leading role belongs to vibration sensitivity the main link between the human body and the impact on it of the environment. The patient's tissues are affected using devices for vibrotherapy, using mechanical vibrations with a frequency of 10 to 250 Hz in continuous or pulsed modes. Vibrotherapy has trophic, reflex, neuroprotective, myorelaxing, anti-inflammatory, analgesic, oxygenating, antioxidant effects and is recommended for prevention, treatment and rehabilitation in various nosologies and conditions of the human body. In addition to the above, vibrotherapeutic effects contribute to the formation of protective and adaptive mechanisms.
Application of therapeutic mud «tomed» in clinical practice: textbook
Authors: Kulikov A. G. , Zaitseva T. N. , Voronina D. D.
Published: April 2021

Authors on the basis of available scientific data and their own clinical observations summarized information concerning the use of peloidotherapy. The historical aspects of mud treatment are described, the classification of the main types of mud is given, indications and contraindications to peloidotherapy are presented. The principles of the purpose and application of resource-saving mud treatment technologies are described in detail. The characteristic of mud preparations of the "TOMED" series is given.
Anthrax in Dagestan: clinical and epidemiological characteristics, risks, and prognosis of a group outbreak in 2019
Authors: Shakhmardanov Murad Z. , Abusuevа Aida S. , Nikiforov Vladimir V. , Tomilin Yuri N. , Burova Svetlana V.
Published: April 2021

Anthrax continues to pose a serious problem for the healthcare and agricultural industries of Russia. Since 1900, over 70,000 outbreaks of human and animal infection have been recorded in Russia. Despite ongoing anti-epidemic measures, epizootics and epidemic foci of anthrax are recorded annually. Over the past 10 years, 23 anthrax outbreaks among people have been recorded in the Russian Federation with a morbidity rate of 90 people, and three fatal outcomes were observed. The Caucasus region ranks first in the Russian Federation in the incidence of anthrax in people and animals. The Republic of Dagestan is a region that is highly prone to anthrax. The spread is aggravated by landscape and environmental conditions that are favorable to the formation and long-term existence of anthrax foci. In most cases, the disease arises in areas previously considered safe for this infection, which indicates the presence of unregistered animal burial sites and the lack of proper control over sanitary condition. People become infected with anthrax due to the uncontrolled and forced farm slaughter of sick animals resulting from the lack of facilities for sanitary slaughter. Human infection occurs mainly during the slaughter of sick cattle, carving, and contact with animal raw materials. This article illustrates a group of anthrax outbreaks that occurred as a result of contact with a sick animal during slaughter and carving. Four local residents of one village fell ill, and in all of them, anthrax manifested in the form of a moderate skin course. The last case of anthrax in cattle in the said locality was recorded in 1958. This fact highlights the importance of compliance with anti-epidemic measures, including the so-called settlements that are safe for anthrax.
ANALYSIS OF THE LEVEL AND RATE OF LEGIONELLA PNEUMOPHILA CONTAMINATION OF HOT WATER SUPPLY SYSTEMS IN THE THERAPEUTIC-AND-PROPHYLACTIC INSTITUTIONS OF MOSCOW
Authors: Gruzdeva O. A. , Filatov N. N. , Sadretdinova O. V. , Karpova T. I. , Dronina Yu. E. , Shustrova N. M. , Alyapkina Yu. S. , Fokina V. G. , Nikitina G. Yu. , Drozdova N. E. , Nikolskaya Yu. V , Tartakovsky I. S.
Published: April 2021

The specific features of Legionella colonization of water supply systems were studied in the large healthcare facilities (HCF) of Moscow. Examination of 16 buildings of 5 Moscow multidisciplinary HCFs, including their risk-group units, revealed the high level (68%) of Legionella pneumophila contamination of hot water supply systems. Among the Legionella pneumophila strains circulating in the hot water supply systems of Moscow HCFs, there was a preponderance of its serogroup 6 (44%), 5 (26%), and 1 (13%) strains. The findings suggest that it is necessary to arrange a set of prophylactic measures for microbiological monitoring and protection of water systems in the HCFs, which are aimed at preventing nosocomial legionellosis.
CONTINGENCY OF THE EPIDEMIC PROCESS OF HANTAVIRUS INFEC-TION WITH ACTIVITY OF EPIZOOTIC PROCESS IN POPULATIONS OF MTCE OF THE GENUS APODEMUS
Authors: Slonova R. A. , Kushnareva T. V. , Maksema I. G. , Kompanets G. G. , VIunikhina O. Viktorovna
Published: April 2021

On the base of long-term analysis ofprevalence of the hemorrhagic fever with renal syndrome (HFRS) and data of hantavirus infections in Apodemus mice - reservoirs ofpathogenic hantaviruses, the relation between of spatio-temporal peculiarities of prevalence of HFRS in Primorye Territory with activity of epizootic process in rodent populations during different phases of their population cycles has been established.
THE DYNAMICS AND STRUCTURE OF THE DETECTION OF HIV INFECTION AT THE STAGE OF RECRUITMENT OF CITIZENS FOR MILITARY SERVICE AND DURING THEIR MILITARY SERVICE IN THE ARMED FORCES OF THE RUSSIAN FEDERATION
Authors: Akimkin V. G. , Parshin M. Zh. , Zemlyakov C. V.
Published: April 2021

HIV infection is a major threat to national security of the Russian Federation. Unfavorable epidemiological situation of HIV infection and drug addiction in Russia leads to a significant increase in the number of conscripts, recognized unfitfor military service on health grounds in connection with this disease. The quantitative and structural indices of detection of HIV infection in people at the stage of recruitment and during the period of their service in the Armed Forces of the Russian Federation in the dynamics have been analyzed. The most detection rate of HIV infection in soldiers in the regions of the Russian Federation with high prevalence of HIV = disease has been established. With aim to prevent the carrying and further spread of HIV infection in the Armed Forces of the Russian Federation the performance of the mandatory medical examination ofpersons qualifying for induction has been suggested.
INTERFERENCE INTERACTION OF VIRUSES IN THE REGULATION OF AN EPIDEMIC PROCESS
Authors: Larin V. F. , Zhukova L. I. , Lebedev V. V. , Rafeyenko G. K.
Published: April 2021

A long-term trend in the incidence of viral hepatitis A (VHA) in relation to vaccine prevention of this disease and poliomyelitis were analyzed in the Krasnodar Territory. There were lower VHA morbidity rates, which coincided with the period of additional mass immunization of children against poliomyelitis. Comparison of the frequency of polio vaccination and the trend in VHA incidence suggests that the viral interference phenomenon is involved in the regulation of its epidemic process, as a result of which vaccine poliomyelitis virus suppresses naturally circulating hepatitis virus A.
THE VALUE OF ACUTE RESPIRATORY VIRAL INFECTIONS IN THE DEVELOPMENT OF CHRONIC HEART FAILURE DISEASE IN CHILDREN
Authors: Ruzhentsova T. A. , Gorelov A. V
Published: April 2021

The data on clinical, ECG, ultrasound and laboratory features of myocarditides that developed in children with acute respiratory viral infections (ARVI) have been presented in this article. The dynamics of changes and the identified possibility of forming the chronic pathology in a one year after the onset of the disease has been shown.
Changes in the activity of antioxidant system in patients with influenza
Authors: Nagoev B. S , Betsugova A. M
Published: April 2021

N THE STUDY THE ANALYSIS OF INDICATORS OF ANTIOXIDANT DEFENSE IN INFLUENZA HAS BEEN PERFORMED. THE REGULARY INHIBITION OF CERULOPLASMIN WITH A MAXIMUM REDUCTION IN THE ERUPTIVE PHASE OF CLINICAL MANIFESTATION OF INFLUENZA AND REGULAR SIGNIFICANT INCREASE IN ERYTHROCYTE CATALASE ACTIVITY WITH A MAXIMUM VALUE AT THE HEIGHT OF THE DISEASE HAS BEEN ESTABLISHED. DURING EXTINCTION OF CLINICAL SYMPTOMS, THE GRADUAL INCREASE IN THE ACTIVITY OF CERULOPLASMIN IN THE BLOOD PLASMA WITH A SIGNIFICANT DECLINE IN CATALASE ACTIVITY OF ERYTHROCYTES TOOK PLACE. AT THE EARLY CONVALESCENCE STAGE CERULOPLASMIN ACTIVITY IN PLASMA CONTINUED TO INCREASE, AND THE LEVEL OF ERYTHROCYTE CATALASE ACTIVITY REMAINED SIGNIFICANTLY ELEVATED. NORMALIZATION OF ERYTHROCYTE CATALASE ACTIVITY IN RED BLOOD CELLS OCCURRED IN THE EARLY PERIOD OF CONVALESCENCE. CHANGES IN INDICATORS OF THE ANTIOXIDANT DEFENSE IN THE DYNAMICS OF INFLUENZA DEPENDED ON THE STAGE, SEVERITY AND CHARACTER OF COMPLICATIONS AND CONCOMITANT DISEASES.
ON THE QUESTION OF THE PATHOGENESIS OF HIV-INFECTION: THE ROLE OF IMMUNE ACTIVATION IN PROGRESSION OF DISEASE
Authors: Khasanova G. R. , Mustafin I. G. , Anokhin V. A.
Published: April 2021

Hyperactivaion of immme system is considered by most investigators as importantfactor, contributing to progression of HIV-infection and development ofAIDS. In the review modern knowledge about mechanisms and results of activation of immune system during HIV-infection are presented. HIV itself, opportunistic pathogens and components of gut microbiota, first of all, endotoxins ofgram-negative bacteria are considered as probable "activators" of immune system. High levels of endotoxin and markers of immune activation are associated with an even greater rate of progression of HIV-infection.
Epidemic manifestations of brucellosis in the safe area
Authors: Nafeev A. A , Burgaeva N. T , Nikulkina N. P , Bezik V. V
Published: April 2021

This report presents the epidemiological situation of brucellosis in the Ulyanovsk region. In the territory of the Ulyanovsk region brucellosis in humans for the first time was reported in 1950. For nearly forty years only chronic cases of brucellosis among the professional groups of population (breeders, veterinarians, meat processing plant personnel) were recorded, that confirms the professional nature of the disease. At the same time on a relatively calm background sporadic cases of brucellosis detected in both acute (1996), and subacute form (2005) in children are revealed. This confirms the position that the activity of the epidemic process in zoonotic infections is influenced by both biological (especially the pathogen and the immunological reactivity of human and animal), and social factors (the system of arrangement of epidemiological-epizootological supervision on the territory).
A CASE OF IMPORTED DENGUE HEMORRHAGIC FEVER IN OMSK
Authors: Safonov A. D.
Published: April 2021

The paper provides a clinical and laboratory description of a case of dengue hemorrhagic fever imported by our countryman from Thailand to Omsk. It shows that the hemorrhagic fever of the disease may be developed in Russian citizens during multiple visits to endemic areas.
THE STUDY OF THE ANTIMICROBIAL ACTIVITY OF SOME NEW AZO DERIVATIVES OF PYRIDOXINE AND THEIR ZINC COMPLEXES
Authors: Aliyev N. N. , Heydarova F. A.
Published: April 2021

For the first time with the use of conventional techniques the overall toxicity and the antimicrobial activity of some new substances - pyridoxine azo derivatives (mercurions), obtained an international registration (CAS, USA) and their zinc-complexes have been studied. St. aureus, E.coli, Pseudomonas aeruginosa, and Candia albicans were used as a test cultures. The investigated compounds were established to have low toxicity (LD 50 failed to detect, with a maximum dose of introduced animals as 0.01 g ≈ 20 g), and some of them were shown to have pronounced antimicrobial activity. In contrast to free mercurions their zinc complexes show activity against strains of some microorganisms (St. aureus, Candida albicans), as well as similar antimicrobial activity in the lower (2-4 fold) concentrations.
MORPHOLOGICAL BASIS OF AUTOIMMUNE MANIFESTATIONS IN VIRAL HEPATITISES
Authors: Umbetova K. T. , Volchkova E. V. , Kiselevsky M. V. , Parkhomenko Yu. G. , Shuba L. I. , Pak S. G.
Published: April 2021

The purpose of the study - to study morphological basis of extrahepatic lesions and autoimmune manifestations in chronic viral hepatitises Methods of performance. By indirect immunofluorescence ASMA, AMA, ANA, by enzyme immunoassay - the Anti-LKM-1 were determined. Cryoglobulins (CG) have been revealed with the use of qualitative visualization method, rheumatoid factor (RF) was determined in serum by semiquantitative latex agglutination on a slide. Patients underwent liver biopsy. A punction liver biopsy according to Mengini was performed with the subsequent histologic and morphological research of obtained liver bioptates with the use of an immunohistochemKal and immunocytochemical methods. Results. In patients with chronic viral hepatitis autoimmune manifestations (RF, CG, ASMA, ANA, AMA, anti-LKM-1) were identified at the same rate regardless of the degree of histological activity. In the liver bioptate in patients with chronic viral hepatitises the complex of regulatory T cells (CD4 + CD25 +), which indicates to the presence of morphological and functional basis for the formation of autoimmune manifestations against persistent viral infection was detected. Conclusion. Identified by ourselves autoimmune manifestations in the blood serum be embodied in the morphological changes of the liver tissue, at that the morphological changes characteristic of autoimmune hepatitises, are observed mainly in patients with chronic viral hepatitis B and C, with moderate and high histological activity.
THE ATTITUDE OF MEDICAL STAFF, INCLUDING THE SENIOR STUDENTS OF THE MEDICAL INSTITUTE, TO THE PROBLEM OF CHRONIC VIRAL HEPATITIS B AND C
Authors: Dudnik O. V , Orlova S. N , Fedorovykh L. P
Published: April 2021

The attitude of medical personnel, including the senior students of the medical Institute, to the problem of chronic viral hepatitis B and C. In the article the data of the sociological research performed among the medical personnel of various medical institutions of Ivanovo, and also students of V and VI courses of the State Budgetary Educational Institution of Higher Professional Education "The Ivanovo state medical academy" of Ministry of Health of Russia, to determine a position of medical workers on a problem of communication of chronic virus hepatitises (VH) B and C are presented. It became clear that the majority of health care workers have to provide care to VH patients in the conditions of shortage of knowledge and ignoring of necessary means of protection, and 18,5% of medical workers have a negative attitude to the VH patients, restricting them in necessary parenteral manipulations.
IMMUNOLOGICAL PARAMETERSAND BLOOD LYMPHOCYTE ENZYME PROFILE IN BABIES WITH RECURRENT RESPIRATORY INFECTIONS
Authors: Kurtasova L. M , Lubnina T. V.
Published: April 2021

84 babies aged 1 to 3 years suffered from recurrent respiratory infections were studied. Cellular and humoral immunological parameters, phagocytic activity of neutrophils and activities of NAD- and NADP-dependent dehydrogenases in peripheral blood lymphocytes were estimated. Immunophenotypic changes found in blood lymphocytes included decreased IgA levels and a tendency of serum IgM to increase. An elevated level of circulating immune complexes was revealed in the blood serum. Decreased levels active neutrophils in the peripheral blood were detected. In the enzyme status of blood lymphocytes such changes as increased levels of synthetic processes and intense intracellular energy metabolism can be observed.
AGE ASPECTS OF THE CLINICAL AND IMMUNOLOGICAL MANIFESTATIONS OF COXIELLOSIS
Authors: Karpenko S. F. , Galimzyanov Kh. M. , Kasimova N. B. , Rubalski O. V. , Kraskov A. V. , Goryeva O. N.
Published: April 2021

There are presented results of the clinical follow-up of 64 patients with moderate course of coxiellosis in whom the circulating immune complexes in the blood serum have been determined. All the patients received routine therapy, 29 patients were administered cycloferon intramuscularly, in dose of 2 ml, on the 1st, 2nd, 4th, 6th and 8th day of treatment. Clinical evidences of coxiellosis in the patients under routine treatment have been seen to be longer in the patients older than 50. Complex therapy with the use of cycloferon shortened the longevity of clinical evidences of the disease. By this the dependence of duration of clinical evidences of coxiellosis on the age disappeared. Content of circulating immune complexes of different sizes was higher in patients older than 50 years who received routine treatment only. Administration of cycloferon led to decreasing of activity of pathological immune complex processes and restoration of the normal content of common, average and low-molecular circulating immune complexes.
Optimization of tactics of management of patients with chronic hepatitis C
Authors: Korochkina O. V. , Ryumin A. M.
Published: April 2021

The prognostic significance of characteristics of patients (gender, age, infectious dose, the presence of habitual intoxication) and of the virus (replicative activity, genotype, viral load, viral kinetics) in the natural course of HCV infection and the probability of achieving sustained virologic response (SVR) as a result of antiviral therapy (AVT ) were studied. The natural course of chronic hepatitis C (CHC) infection in 100 patients and the effectiveness of AVT in 68 CHC patients have been analyzed. The factors that determine the unfavorable course of CHC (male gender, age at the moment of infection older than 30 years, infection through a hemotransfusion or drug use, the presence of habitual intoxications, virus 3a genotype, and the presence of a/HCV NS3 and a/HCV NS5). The factors that determine a high probability of achieving SVR are detected. In this case the treatment by AVT, regardless of the prognosis of the natural course of HCV is recommended
SEROTYPING OF STREPTOCOCCUS PNEUMONIAE STRAINS, ISOLATED FROM CHILDREN IN URAL REGION WITH THE USE OF MULTIPLEX PCR
Authors: Samatova E. V. , Druy A. E. , Tsaur G. A. , Boronina L. G.
Published: April 2021

This article presents results of the multiplex PCR investigation of the serotypes distribution of S. pneumoniae strains circulating in Ekaterinburg and the Sverdlovsk region. This study was performed in children with invasive, noninvasive pneumococcal infections and carriers. 118 strains of pneumococci typed out of 129 ones (91.5%) referred to the 15 serotypes: 6A, 6B (20,8%); 23F (13,9%); 19F (11,5%); 8, 9V, 9A, 11F, 11A, 11B, 11C, 11D, 12F, 15A, 33F (11,5%); 3 (10%) 2, 15F, 17F, 22F, 23B (3,9%); 18B, 18C (3.9%), 19A (3,2%); 7F, 19B, 19C, 23A (3,2%); 5,10A (1.6%), 20 (1.6%), 14 (1, 6%); 9L, 9N, 15B, 15C (1,6%); 18F (1,6%); 18A (1.6%). Coincidence rate of serotypes S. pneumoniae, isolated from children with chronic infectious and inflammatory diseases of the lung with serotypes included into the content of the conjugate vaccines is: 7-valent - 69.3%, 10-valent - 98.2%, 11 - and 13-valent - 100%.
PERTUSSIS IN CHILDREN OF EARLY AGE
Authors: Petrova M. S , Popova O. P , Borisova O. Yu , Abramova E. N , Vartanyan R. V , Kelli E. I
Published: April 2021

Among children of early age still severe forms of a disease which can lead to lethal outcomes are registered still most often. Untimely diagnostics and the wrong assessment of the severity of pertussis cause mistakes in treatment and are significantly impact on a disease outcome. The analysis of features of a course of pertussis in children of early age is based on supervision over 670 children hospitalized in Moscow Infectious Clinical Hospital No. 1. Studying of clinic picure of pertussis in comparative evolutionary aspect allowed to establish the main reasons for an adverse course of pertussis a lethality at the present stage. The main factors promoting development of severe forms of a Bordetella pertussis infection in children of early age are the anatomical and physiological features, the burdened premorbid background, accompanying infectious diseases and biological properties of circulating strains of a Bordetella pertussis microbe. Pertussis in children of early age has own the clinical features, being characterized first of all by severity of the disease course. The most significant options of a mixtinfection are a combination of pertussis with CMV infection, the RS-infection.
CURRENT CLINICAL, LABORATORY AND GENDER FEATURES OF ERYSIPELAS
Authors: Ratnikova L. I. , Ship S. A.
Published: April 2021

There were investigated clinical and laboratory parameters in patients with erysipelas in dependence on the gender. There were examined 145 patients with erysipelas, aged 18 to 64 years. Among the examined cases females consisted 65.9%, males — 34.1%. The clinical picture of erysipelas in females was characterized by a greater degree of severity. Age-related dishormonal changes in females burden the disease. Production of pro-inflammatory cytokines (IL-1a and TNF-a) in patients with erysipelas has no gender differences. The presented data revealed the modern clinical laboratory and gender characteristics of erysipelas.
THE INFLUENCE OF SOME FACTORS ON THE FORMATION OF BIOFILM BY TOXIGENIC AND NON-TOXIGENIC VIBRIO CHOLERAE EL TOR STRAINS
Authors: Tatarenko O. A. , Alekseeva L. P. , Telesmanich N. R. , Shestialtynova I. S. , Chemisova O. C. , Markina O. V. , Nepomnyashchaya N. B. , Uskova N. N.
Published: April 2021

The early stages of biofilm formation on polystyrene surface were studied in 14 Vibrio cholerae El Tor strains, all of which carried genes of vps cluster, mshA, and hapR genes. 13 Vibrio cholerae El Tor strains were shown to be capable of adsorption on the walls of microtiter plate wells and of ring formation at the "polystyrene-medium" interface. One of the Vibrio cholerae El Tor strains tested was defective in this ability. The use of different media - modified M1 medium and 1 per cent peptone - failed to reveal sufficient influence of culture medium composition on the ability of Vibrio cholerae to form multilayer biofilm at the phase boundary "polystyrene-medium". Temperature reduction from 37°C to 25°C also didn t result in statistically significant enhancement of monolayer formation in both media. Quantitative evaluation of biofilm formation showed that this ability was clearly marked only in two toxigenic and two non-toxigenic strains of Vibrio cholerae El Tor. Monolayer comparison in ELISA demonstrated that only two toxigenic and two non-toxigenic strains possessed the ability for exopolysaccharide production.
THE STUDY OF THE LEVEL OF NEUROTRANSMITTER SEROTONIN FOR THE PREDICTION OF THE PARALYTIC FORM OF TICK-BORNE ENCEPHALITIS
Authors: Sumlivaya O. N. , Vorobiova N. N. , Karakulova Yu. V. , Nebolsina A. P. , Patrakova L. S. , Ivantsova S. G.
Published: April 2021

This paper presents the results ofa quantitative study ofserotonin in blood platelets in patients in the acute period ofencephalitis. Regardless of the clinical form of infection, in patients, there was revealed a significant decrease in this index 203,7 ± 107,1 ng/ml relatively to control values: 585,4 ± 258,8 ng/ml, respectively (p
Method of forecasting the probability of progression of the clinical 37 stage of HIV infection
Authors: Zatoloka P. A , Dotsenko M. L
Published: April 2021

The method of forecasting the probability of progressing of clinical stage of HIV-infection has been developed. The method includes bacteriological examination of mucosal membrane scrapings from the posterior wall of oropharynx in HIV-infected patients without clinical signs of disease of the pharynx, and the counting of fungi of the Genus Candida. In identifying the fungi of the genus Candida in the number of colony-forming units equal to or more than 103, the high probability which is 0.95 (forecasting of the positive the result) of transition of the clinical stage of HIV infection within the next 6 months into following clinical stage of the disease is stated,
MELIOIDOSIS: RESULTS OF CENTENARY STUDY, MODERN PROBLEMS AND NEAREST PERSPECTIVES
Authors: Ilyukhin VI. I , Senina T. V.
Published: April 2021

The paper summarizes the data on scientific investigations of melioidosis from the date of its discovery by A. Whitmore in 1912 up to now. The particular attention has been attracted to the modern conception of epidemiology, diagnosis, treatment of the disease and also ecology of its agent (Burkholderia pseudomallei). The nearest perspectives on organizational, methodical and scientific developments on prophylaxis and treatment of this particularly dangerous infectious diseases are suggested.
FLU IN PREGNANT WOMEN
Authors: Popov A. F. , Kiselev O. I.
Published: April 2021

It is shown that in addition to increased susceptibility in pregnant women to influenza virus in them more often severe and complicated forms of the infection are recorded. The frequency of mortality from influenza, complicated by pneumonia, in the mothers during the pandemic period in 2009 was 2.5% and perinatal loss amounted to 8.3%. There are presented data on the relationship of the disease of pregnant women with influenza with developmental malformations in their offsprings. Obstetric tactic is determined individually for each pregnant depending on the period of parturition. Antiviral therapy of influenza A (H1N1) pdm09 in pregnant with arbidol drugs, oseltamivir, viferon reduced the rate of preterm labors, congenital pneumonia and cerebral ischemia in newborns. The main methods of preventing influenza is vaccination, which is allowed from the II trimester of gestation. Post-exposure antiviral chemoprophylaxis in pregnants is expedient to perform with zanamivir. There are listed all the errors in the management of pregnant women with influenza, which significantly reduced the effectiveness of treatment and increased incidence of adverse outcomes.
THE EVALUATION OF SANITARY-HELMINTHOLOGICAL STATE OF THE SOIL AND WATER
Authors: Sarbasheva M. M. , Bittirova A. A. , Atabieva Zh. A. , Bittirov A. M. , Bittirov An. M.
Published: April 2021

In the Republic of Kabardino-Balkaria 64% of soil samples in a flat area, 75% of the samples in the piedmont area and 42% in the mountainous area contained Taeniarhynchus saginatus eggs in the number of of 46.2 - 112.6 eggs /g of soil. Duration of viability of the cestode eggs in a flat area is 420 days, in the foothills - 397 days, in the mountainous area - 210 days.
ACADEMICIAN P. A. VERSHILOVA AND DOMESTIC EPIDEMIOLOGY (ON THE OCCASION OF THE 20TH ANNIVERSARY OF HER DEATH)
Authors: Knopov M. Sh. , Taranukha V. K.
Published: April 2021

The life and career way of a prominent national epidemiologist and microbiologist, talented organizer, known public health figure, a wonderful teacher, Academician of the USSR Academy of Medical Sciences, Professor Pelageya Albertovna Vershilovoya is presented in the paper.
THE SUCCESSFUL EXPERIENCE OF ANTIVIRAL THERAPY FOR HEPATITIS C IN PATIENTS WITH HEPATOCELLULAR CARCINOMA IN THE EARLY POSTOPERATIVE PERIOD
Authors: Poluektova V B. , Czhao A. V. , Konstantinova M. M. , Davydenko P. I. , Shevchenko T. V. , Filippova E. M. , Volchkova E. V.
Published: April 2021

To show the need for a comprehensive assessment of non-invasive, invasive and laboratory examination of patients with newly diagnosed hepatitis, especially in presence of space-occupying lesions of the liver (cysts) for detection of cancer pathology. Methods of performing. To confirm the diagnosis of HCC, the following instrumental methods of examination of the patient have been performed: ultrasound, CT and MRI of the internal organs of the pelvis and abdomen. The puncture of cystic formation was performed with the purpose of morphological verification of the diagnosis. A morphological and histological study of the tumor was performed. Evaluation of laboratory parameters included the basic general clinical and biochemical analyzes, as well as FibroMax, tumor markers: CEA, SA19-9, AFR, the qualitative and quantitative determination of HCV RNA. Results. Showed that taken separately laboratory values or single screening tool examination fail to give the fully valid answer about the nature and course of the pathological process. Conclusion. Comprehensive evaluation of patients with newly diagnosed HCV and timely initiated antiviral therapy permit to prevent or postpone the promote manifestations of chronic HCV, to preclude the development of primary HCC and its recurrence. When making a decision on the tactics of the management of the patient it is necessary to consider the totality of all the necessary instrumental and non-instrumental and laboratory methods of examination Keywords: chronic viral hepatitises C, hepatocellular carcinoma, oncomarkers, treatment of HCC and CHCV
STATE OF THE MICROMYCETES CONTAMINATION OF ENVIRONMENTAL OBJECTS OF AN INFECTIOUS HOSPITAL
Authors: Charushina I. P , Feldblyum I. V , Semerikov V. V , Aleksandrova G. A , Balandina S. Yu , Chetina O. A , Metelkina N. A
Published: April 2021

The article presents the characteristic of laboratory test results on micromycetes of objects of the environment in the medical infectious institution. 76 samples were investigated. The high micromycetes contamination level of the hospital premises was found, positive samples accounted for 97,36%. In the etiological structure of micromycetes mold fungi prevailed. The most unfavourable premises of the hospital on micromycetes dissemination were twenty-four hour stay wards and the procedure unit.
EPIDEMIC AND EPIZOOTIC CYCLICAL EXACERBATIONS OF ANTHRAX
Authors: Arutyunov Yu. I. , Kireev Yu. G.
Published: April 2021

In the paper the epidemic and epizootic periods of exacerbations of anthrax outbreaks were analyzed. The repetition time of such outbreaks has been shown to be equal 9-11-years, depending on solar activity. The greatest number of permanently disadvantaged anthrax points was found to be recorded in the phase of minimum solar activity in the minimum solar activity year and the preceding two years (m, m-1, m-2), and in the maximum phase - in the maximum solar activity year and a in the second year after it (M, M +2). The greatest number of human and animal disease rate, in addition to these terms takes place also in two following years (m +1, m +2 and M +3, M +4).
THE CLINICAL COURSE OF INVASIVE CANDIDIASIS IN HIV-INFECTED PATIENTS
Authors: Charushina I. P. , Vorobiova N. N. , Lyapustin S. B. , Zemskov A. G.
Published: April 2021

The article presents the results of observation of 21 patients with invasive candidiasis, developed on the background of HIV infection for the period 2007-2013. The features of clinical course of the disease and the risk factors for its occurrence are described. The clinical ркЫп of invasive candidiasis in HIV-infected patients is similar to the clinical picturde seen in bacterial sepsis, it is characterized by the severe course and the high fatality. The risk factors are the pronounced immune deficiency, the absence of antiretroviral ^тру and the presence of 2 or more foci of the s^etAnal candidiasis. The diagnosis of the hematogenous dissemination should be carried out in all HIV-infected patients with the reference symptoms.
EFFECTIVENESS OF DOMESTIC ANTIRETROVIRAL NRTI CLASS DRUG IN THE MONOTHERAPY OF HIV INFECTION
Authors: Vorobiova N. N. , Ivanova E. S.
Published: April 2021

The effectiveness of domestic preparation Phosphazide was proved during the performance of the retrospective analysis of a clinical case of monotherapy in a 28-year-old female with HIV infection. Phosphazide was prescribed after the achievement of virological and immunological effect of combined schedules of antiretroviral therapy. The dynamics of CD4 lymphocytes, plasma HIV RNA [viral load test (VL)] were followed up every 3 months for 372 weeks. The persistent decline in VL and keeping it at the level less than 3,79 log10 in combination with a positive clinical effect - the lack both of symptoms of progression of HIV infection and the development of opportunistic infections, stable level of CD4-lymphocytes> 500 cells/mcl can be considered as a positive result of monotherapy with Phosphazide.
Acquired overt cytomegalovirus infection in immunocompetent adult patients
Authors: ZHUKOVA L. I. , KOVALEVSKAYA O. L , LEBEDEV V. V , GORODIN V. N
Published: April 2021

There has been analyzed the clinical course of the disease in 94 hospitalized patients with acute acquired overt cytomegalovirus infection, confirmed by serological tests and polymerase chain reaction. Males of young age were shown to suffer more often. In the clinical picture symptoms of intoxication (fever, weakness), hepatomegaly with increased activity of liver enzymes, splenomegaly, the involvement of the airways and lymph nodes available for palpation prevail. The clinical feature of the overt form of cytomegalovirus infection is a frequent combination with infection caused by the Epstein-Barr virus. The comprehensive treatment with introduction of antiviral drugs leads to normalization of temperature, removal of organ lesions and improvement of the patients .
EVALUATION OF REACTOGENICITY, SAFETY AND IMMUNOGENICITY OF DOMESTIC VACCINE "ENCEVIR» WITH A REDUCED ANTIGEN LOAD IN IMMUNIZATION OF CHILDREN 3-17 YEARS OLD ACCORDINGLY TO EMERGENCY VACCINATION PROTOCOL
Authors: Feldblium I. V. , Menshikova M. G , Danilina T. V , OkunevaJ I. A , Perminova O. A , Semerikov V. V , Pavroz K. A
Published: April 2021

The article presents the results of the open comparative randomized clinical study performed in children aged 3 to 17 years which were immunized with the Russian vaccine «EnceVir»® possessing the reduced antigenic load accordingly to emergency vaccination protocol. The aim of the study was to assess reactogenicity, safety and immunogenicity of the vaccine. The vaccine is characterized by a low reactogenicity profile, the high profile of safety, adequate immunogenicity, and it is not yielding to foreign vaccine «FSME-Immun Inject / Junior»
NEW ANTIVIRAL DRUG TRIAZAVIRIN. RESULTS OF PHASE 1 CLINICAL TRIAL
Authors: Deeva E. G , Kiselev Leg Ivanovich , Melnikova Tatjana Ilinichna , Shaldzhan Aram Arutjunovich , Nekrasov Petr Alexeevich , Kiselev Alexey Sergeevich , Zagorodnikova Ksenia Alexandrovna , Charushin Valeriy Nikolaevich , Rusinov Vladimir Leonidovich , Ulomsky Evgeniy Narcissovich , Chupakhin Oleg Nikolaevich
Published: April 2021

In the work there are presented results of the study of the pharmacokinetics, tolerability and safety of a new anti-influenza preparation Triazavirin in several dose regimes, performed in 30 volunteers. There were no recorded adverse reactions associated with the administration of the drug. Study of the pharmacokinetics showed that the maximum concentration of Triazavirin in blood plasma is achieved on average 1 - 1.5 hours after, the curve of decreasing concentrations is two-phase, half-life elimination period in the first phase is 0.5 - 1.4 hour. It is impossible to exclude polymorphic character of metabolism. The extent of systemic exposure depends on the dosage frequency more than the dose of the drug. In this case, there was no noted significant accumulation in long-term use. In the study Triazavirin was well tolerated by all participants in all the studied dose regimes. The preferred regime, providing the maintenance of an effective and safe concentrations is recognized as dosage of the 250 mg twice a day.
Perspectives on tuberculosis control in the Russian Federation
Authors: Makarov V. K. , Krylov V. V. , Lebedev V. M. , Grishkina N. A. , Starikov S. V.
Published: April 2021

In the conditions of the current tuberculosis epidemic situation there are required consolidated efforts of all branches of government, phthisiatricians, general health services net, family medicine, the proper population, public and other organizations and the mass media for the prevention of the spread of this terrible social disease in Russia.
FEATURES OF THE CYTOKINE PROFILE IN CHILDREN SUFFERING FROM PERTUSSIS
Authors: Popova O. P , Fedorova I. M , Koteleva S. I
Published: April 2021

Comparative analysis of cytokine profile was performed in 149 children aged 1.5 to 14 years, out of which 41 had suffered from pertussis as monoinfection, 53 -in combination with mycoplasma infection, 55 - with acute viral infections. Cytokine profile in patients with pertussis differs in reduction of induced production of proinflammatory cytokines, especially IFN-y. A key feature of the functioning of the cytokine network in pertussis is the active production of anti-inflammatory cytokines - IL-4 and IL-10 upward the early periods of the disease, that indicates the importance of Th-2-type response in whooping cough.
EPIDEMIOLOGICAL OF PERINATAL MORTALITY IN OMSK REGION
Authors: Dolgikh T. I , Barinov S. V , Kadtsyna T. V , Chekmarev G. V
Published: April 2021

An epidemiological analysis of basic indices in obstetric aid in the Omsk region in comparison to nationwide data for 2007 to 2011 has been performed. There was identified unfavourable situation of reproductive and demographic characteristics - high incidence of extragenital morbidity in women, increasing the proportion of antenatal losses among as both term as preterm infants also, the prevalence of perinatal mortality in maternity institutions in districts, if compared with similar institutions in the city. There were determined main causes of stillbirth: certain conditions emerging in the perinatal period and intrauterine hypoxia, birth asphyxia. Low indices of neonatal health: a high level of prematurity, a number of infants with developmental retardation, and fetal hypoxia have been ascertained. The directions for improvement of the work of perinatal services in Russia have been suggested.
The results of the monitoring of vibrio cholerae in the Taganrog Bay of the Azov sea in 2011-2012
Authors: Mazrukho A. B , Kruglikov V. D , Monakhova E. V. , Moskvitina E. A , Shestialtynova L. S , Podoynitsyna O. A , Vodopyanov A. S , Vodopyanov S. O , Pisanov R. V. , Zubkova D. A , Kudryakova T. A , Ezhova M. I , Uskova N. N , Skachko M. V
Published: April 2021

The complication of cholera epidemic situation in Ukraine (2011) caused the reinforcement measures on monitoring Vibrio cholerae in seawater in Taganrog Bay in the framework of measures for prevention of the spread of infection over the territory of the Rostov region and the country. Phenotypic and genotypic features of 3 selected atoxigenic strains of Vibrio cholerae eltor O1 and 1 toxigenic strain of V. cholerae eltor Inaba № 301, containing the hybrid prophage were characterized. With great probability there was established the absence of association of this strain with the outbreak of infection within the territory of the neighboring country, but there was revealed his relationship with to imported strains (1999, 2005). Atoxigenic strains were similar to strains previously detected in water bodies of the Rostov region. The implementation of the set of measures for the strengthening of epidemiological control permitted to prevent the importation of infection into the territory of the Russian Federation in 2011 - 2012.