bluuebunny/crossref_metadata_2025 huggingface dataset:
Electron-Microscopic Investigation of the Distribution of Titanium Dioxide (rutile) Nanoparticles in the Rats’ Small Intestine Mucosa, Liver, and Spleen
Authors: Hendrickson Olga D. , Platonova Tatyana A. , Pridvorova Svetlana M. , Zherdev Anatoly V. , Gmoshinsky Ivan V. , Vasilevskaya Lyudmila S. , Shumakova Аntonina А. , Hotimchenko Sergey А. , Dzantiev Boris B.
Published: April 2019

Background:

Titanium dioxide (TiO2) is currently one of the most widely known
nanomaterials produced for different purposes. The adverse effects of nano-dispersed TiO2 cause a
serious concern about human health problems related to the intake of TiO2 nanoparticles (TiO2 NPs).
The investigation of TiO2 NPs’ penetration through the gut epithelium into secondary organs and the
relevant biological effects has an undoubted importance when assessing the potential risk of using
TiO2 NPs.

Objective:

In the current study, we investigated the effect of rutile TiO2 NPs on tissues of the small
intestine, liver, and spleen. For this purpose, we used a physiological model that simulates the single
administration of TiO2 NPs directly into the intestinal lumen of an experimental animal.

Methods:

Suspensions TiO2 NPs were administered via an isolated loop of the small intestine at a
single dose of 250 mg/kg of body weight. TiO2 NPs were detected in rats’ tissues by transmission
electron microscopy.

Results:

TiO2 NPs were found in tissues of the small intestine mucosa, liver, and spleen. The administration
of TiO2 NPs resulted in different changes in the cellular ultrastructures: hyperplasia of the
smooth endoplasmic reticulum, an increase in the size of the mitochondria, the emergence of local
extensions into the perinuclear space, and the appearance of myelin-like structures.

Conclusion:

The ultrastructural changes found in the individual cells of the small intestine, liver, and
spleen indicated intracellular pathology, induced by the high doses of the TiO2 NPs. The spleen
tissue appeared to be the most sensitive to the effect of TiO2 NPs.
The Role of Nanofiltration in the Pathogen Safety of Biologicals: An Update
Authors: Inouye Masaharu , Burnouf Thierry
Published: April 2019

Nanofiltration technology to remove possible pathogenic viruses during biopharmaceutical
manufacturing was introduced in the biopharmaceutical industry in 1989. The very first industrial
implementation took place in the early 1990s, through commercial manufacturing processes of plasma-
derived medical products. Then it was applied to recombinant protein medical products, including
monoclonal antibodies. In the first review published in 2005 in this journal, the technology was
already considered promising and was much welcomed by the industry, but it was still a relatively
emerging technology at that time, and many questions were raised about its robustness as a reliable
virus-removal tool. We conducted a review to update the published information (SCI journals and
suppliers’ documentation) existing on the use of nanofiltration as an industrial process for removing
viruses from various biologicals. After almost a decade from the previous review, nanofiltration has
established itself as a routine production step in most biopharmaceutical manufacturing. It has become
one of the essential manufacturing processes used to assure safety against viral contamination.
The technology is applied to manufacturing processes of various biologicals (human plasma products
and complex recombinant proteins, such as coagulation factors and monoclonal antibodies made
from mammalian cells). Many biologicals that undergo nanofiltration are licensed by regulatory
authorities, which illustrates that nanofiltration is recognized as a robust and safe virus-removal method.
No adverse events related to the use of nanofiltration have been recorded. New trends in
nanofiltration technology continue to appear. As was identified during its introduction to the market
and predicted in the previous review, nanofiltration has achieved major technical breakthroughs for
ensuring the safety of biologicals, particularly human plasma-derived products, against viruses.
Understanding Twitter Hashtags from Latent Themes Using Biterm Topic Model
Authors: Bhat Muzafar R. , Bashir Burhan , Kundroo Majid A. , Ahanger Naffi A.
Published: April 2019

:

Social media, in general, and Twitter, in particular, provide a space for discourses,
contemporary narratives besides a discussion about few specific social issues. People respond to
these events by writing short text messages.

Background:

Hashtag “#”, a specific way to respond to a given raised discourse, narrative or any
contemporary issue is usual to social media. Netizens write a short message as their opinion about
any given issue represented using a given Hashtag. These small messages generally tend to have a
latent topic (theme) as one’s opinion about it.

Objective:

This research is aimed to extract, represent and understand those hidden themes.

Methods:

Biterm Topic Model (BTM) has been used in this study given its ability to deal with the
short messages unlike Latent Dirichlet Allocation that expects a document to have a significant
length.

Results:

Twitter Hashtag #M
comments. Data has been modelled with ten (10) topic.

Conclusion:

The experimental results show that the proposed approach to understand the twittter
hashtages from latent themes using biterm topic modelling method is very effective as compared to
other methods.
Compact Flow-Through Electrochemical Cell - A Novel Perspective in Industrial Manufacture of Perchlorates
Authors: Menon Sananth H. , Madhu G. , Mathew J.
Published: April 2019

Background:

Sodium Perchlorate is one of the major starting intermediate product for the manufacture of various Perchlorates viz, Ammonium perchlorate as solid oxidizer and Strontium Perchlorate as Secondary Injection Thrust Vector Control (SITVC) in launch vehicles. This critical product is manufactured industrially by electrochemical oxidation of Sodium Chlorate solution at the anodic surface. Lead dioxide is preferred in various perchlorate cells because of its low cost. Infrequent detachment of Lead dioxide deposits from the substrate during electrolysis is a grave issue confronted by associated electrochemists in bulk manufacture of chemicals. Moreover, a cheaper alternative for continuous manufacture of Sodium Perchlorate using Lead dioxide electrodes has been an onus among various industrial electrochemists.

Objective/ Benefits:

Development of a suitable compact flow through electrochemical cell using superfluous or detached Lead dioxide crystals as ‘particle’ electrodes is the major objective of this paper. This compact bed electrochemical cell, is extraordinarily helpful when confronting with lesser reactant concentration or time consuming reactions. Besides, this proposal adds on flexibility in trimming the size of cells when compared with bulky design of conventional cells. Another objective was to demonstrate continuous electrosynthesis of Sodium perchlorate using Lead dioxide without resorting to expensive Platinum.

Method:

A suitable single bed and a dual bed compact electrochemical cell was made using HDPE body, perforated Poly Propylene distributor, detached Lead dioxide particles, nylon mesh, etc. Four such dual bed cells were made for final demonstration for continuous electro synthesis application.

Results:

From various experimental trials, an optimum values for temperature, flow rate and current load were determined as 600°C, 800 mL/min and 80 A respectively, in single bed system. Inorder to avoid current penetration issue, dual bed cells were employed. Subsequently, critical operational strategy and systematic configuration for arrangement of dual bed cells were made for demonstrating continuous bed electrochemical cells.

Conclusion

An average current efficiency of about 78.5% could be achieved which is 20-25 % higher than conventional parallel plate electrode system.
Development of Nateglinide Loaded Graphene Oxide-Chitosan Nanocomposites: Optimization by Box Behnken Design
Authors: Deshmukh Rutuja V. , Paraskar Pavan , Mishra S. , Naik Jitendra
Published: April 2019

Background:

Nateglinide is an antidiabetic drug having biological half-life 1.5 h which shows a concise effect. Graphene oxide along with chitosan can be used as a nanocarrier for sustained release of Nateglinide.

Objective:

To develop Nateglinide loaded graphene oxide-chitosan nanocomposites and to evaluate for different characterization studies.

Methods:

Graphene Oxide (GO) was synthesized by improved hummer’s method and drug-loaded Graphene oxide - chitosan nanocomposites were prepared. Box Behnken design was used to carry out experiments. The nanocomposites were characterized for encapsulation efficiency and drug release. Morphology was studied using field emission scanning electron microscope and transmission electron microscope. An interaction between drug, polymer and GO was investigated by Fourier transform infrared spectroscopy and X-ray diffractometer along with in vitro drug release study.

Results:

The statistical evaluation of the design showed linear and quadratic models which are significant models for encapsulation efficiency (R1 0.6883, 0.9473) and drug loading (R2 0.6785, 0.9336), respectively. Fourier transform infrared spectroscopy showed the compatibility of GO, Chitosan and Nateglinide. X-ray diffractometer reveals the change in degree of crystallinity of drug. FE-SEM and TEM images confirmed the distribution of the drug within the nanocomposites. Design expert reveals that the concentration of GO has great influence on encapsulation efficiency. In Vitro drug release showed the sustained release of drug over the period of 12 h.

Conclusion:

GO-Chitosan nanocomposites can be used as a sustained release carrier system for Nateglinide to reduce dose frequency of drug as well as its probable side effects.
Novel Molecular Targets and Mechanisms Involved in the Invasion and Metastasis of Pancreatic Cancer
Authors: Li Ziyi , Li Weidong , Dong Yuqi , Sun Xueying
Published: April 2019

Background:

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancerrelated deaths and its morbidity and mortality are increasing. PDAC patients have a very poor prognosis because of aggressive features of PDAC cells, shortage of reliable diagnostic biomarkers and deficiency of effective therapeutics.

Objective:

The article aims to discuss the recent progress in the discovery of novel molecular targets and their related mechanisms in the invasion and metastasis of PDAC cells.

Methods:

Literatures based on Pubmed database were searched and those related to the molecular targets involved in the invasion and metastasis of PDAC were reviewed.

Results:

The most promising discovery of molecular targets and phenomena include epithelialmesenchymal transition (EMT), cancer stem cells (CSCs), metastasis-related genes, hypoxiainducible factors (HIFs), non-coding RNAs (ncRNAs) and L1 cell adhesion molecule (L1CAM), which contribute to the vital biological behaviors of PDAC cells and tumor microenvironments.

Conclusion:

This review summarizes recent advances in novel molecular targets that regulate the invasion and metastasis of PDAC cells, and how they are targeted for developing diagnostic and therapeutic tools for combating PDAC. Further understanding the regulatory mechanisms of these molecular targets may help to discover biomarkers used for early diagnosis, predicting the prognosis and monitoring treatment response, and also to develop novel effective therapeutics.
Comparative Performance Evaluation of Keyword and Semantic Search Engines using Different Query Set Categories
Authors: Jatwani Poonam , Tomar Pradeep , Dhingra Vandana
Published: April 2019

Background:

Keyword search engines are unable to understand the intention of user as
a result they produce enormous results for user to distinguish between relevant and non relevant
answers of user queries. This has led to rise in requirement to study search capabilities of different
search engines. In this research work, experimental evaluation is done based on different metrics to
distinguish different search engines on the basis of type of query that can be handled by them.

Methods:

To check the semantics handling performance, four types of query sets consisting of 20
queries of agriculture domain are chosen. Different query set are single term queries, two term queries,
three term queries and NLP queries. Queries from different query set were submitted to
Google, DuckDuckGo and Bing search engines. Effectiveness of different search engines for different
nature of queries is experimented and evaluated in this research using Grade relevance
measures like Cumulative Gain, Discounted Cumulative Gain, Ideal Discounted Cumulative Gain,
and Normalized Discounted Cumulative Gain in addition to the precision metric.

Results:

Our experimental results demonstrate that for single term query, Google retrieves more
relevant documents and performs better and DuckDuckGo retrieves more relevant documents for
NLP queries.

Conclusion:

Analysis done in this research shows that DuckDuckGo understand human intention
and retrieve more relevant result, through NLP queries as compared to other search engines.
Marine Originated Fused Heterocyclic: Prospective Bioactivity against Cancer
Authors: Paliwal Deepika , Srivastava Saurabh , Sharma Pramod Kumar , Ahmad Irfan
Published: April 2019

The deep Sea has several herbal sources such as marine organisms. These marine
sources possibly have effective anticancer properties. The fused heterocyclic ring with marine
source has special characteristics with minimum toxicity and with maximum anticancer
effects. The review focused on and classified the prospective lead compounds which have
shown a promising therapeutic range as anticancer agents in clinical and preclinical trials.
Comparative Evaluation of Antiulcer Activity of Ficus religiosa (Stem Bark) Extracts Prepared by Different Methods of Extraction
Authors: Panchawat Sunita , Pradhan Joohee
Published: April 2019

Background:

The stem bark of Ficus religiosa L. (Family-Moraceae) is traditionally
used to treat gonorrhea, diarrhea, dysentery, leucorrhea, menorrhagia, vaginal and other
urogenical disorders, ulcers and gastrohelcosis.

Objective:

The study was aimed at comparing antiulcer activity (ethanol induced gastric ulcer)
for stem bark extracts of Ficus religiosa Linn. prepared by different extraction methods
viz. soxhlet, ultrasonication and microwave assisted extraction.

Methods:

The powdered drug material was extracted by soxhlet (time 48 hours., temperature
60°C and solvent 60% ethanol), Ultrasonic (90 min., 50°C and acetone as solvent)and Microwave
(3 min., 60°C and acetone as solvent) assisted extraction method. The acute toxicity
study was carried out in adult female albino rats by “fix dose” method of OECD guideline
no. 420 for selection of doses. Antiulcerogenic effect of prepared extracts (200mg/kg) was
evaluated by ethanol induced ulcer method using omeprazole (40 mg/kg) as standard drug
and absolute alcohol 99.5% as necrotizing agent.

Result and Conclusion:

Acute toxicity study did not show any significant toxicity signs and
extracts were said to be practically non-toxic at tested dose level of 2000 mg/kg, b.w. The
best antiulcer activity was shown by the hydroalcoholic extract prepared by soxhlet extraction
method. Administration of ethanol produced significant ulcer index (41.00 ± 1.75) in the
control group. Standard drug omeprazole (40 mg/kg) produced percentage protection of
70.31%. Among all three extracts, Ulcer index is significantly (p<0.001) protected by hydroalcoholic
extract (Soxhlet Extraction Method) with percentage protection 52.02%.
Designing Robust N-of-1 Studies for Precision Medicine: Simulation Study and Design Recommendations
Authors: Percha Bethany , Baskerville Edward B , Johnson Matthew , Dudley Joel T , Zimmerman Noah
Published: April 2019

Background

Recent advances in molecular biology, sensors, and digital medicine have led to an explosion of products and services for high-resolution monitoring of individual health. The N-of-1 study has emerged as an important methodological tool for harnessing these new data sources, enabling researchers to compare the effectiveness of health interventions at the level of a single individual.

Objective

N-of-1 studies are susceptible to several design flaws. We developed a model that generates realistic data for N-of-1 studies to enable researchers to optimize study designs in advance.

Methods

Our stochastic time-series model simulates an N-of-1 study, incorporating all study-relevant effects, such as carryover and wash-in effects, as well as various sources of noise. The model can be used to produce realistic simulated data for a near-infinite number of N-of-1 study designs, treatment profiles, and patient characteristics.

Results

Using simulation, we demonstrate how the number of treatment blocks, ordering of treatments within blocks, duration of each treatment, and sampling frequency affect our ability to detect true differences in treatment efficacy. We provide a set of recommendations for study designs on the basis of treatment, outcomes, and instrument parameters, and make our simulation software publicly available for use by the precision medicine community.

Conclusions

Simulation can facilitate rapid optimization of N-of-1 study designs and increase the likelihood of study success while minimizing participant burden.
Gait Characteristics In patients With Ankylosing Spondylitis – a Systematic Review (Preprint)
Authors: Soulard Julie , Vaillant Jacques , Agier Clara-Thémis , Vuillerme Nicolas
Published: April 2019

BACKGROUND

Ankylosing spondylitis (AS) is a chronic rheumatic disease which affects the axial skeleton and sacro-iliac joints. By impacting spinal mobility and physical functions, AS could also potentially impair gait. However, while published data are rather sparse, it appears that discrepancies exist regarding AS consequences on gait characteristics, tasks and analysis techniques used to assess gait ability of patients with AS.

OBJECTIVE

The review questions are twofold: (1) What are the consequences of AS on gait? and (2) How is gait assessed in patients with AS?

METHODS

Databases were systematically searched to identify studies satisfying the search criteria, using the synonyms of ankylosing spondylitis and gait. Two reviewers extracted from the articles study characteristics, sample descriptions, methods and main results in relation to gait.

RESULTS

168 titles were extracted from databases and 17 studies were included in the review. 13 studies (76%) used clinical gait measurements, and 4 (23%) used laboratory gait measurements. Only 6 involved a healthy control group. Gait pattern of patients with AS was more cautious, associated to a decreased pelvic tilt and lower limbs angles in the sagittal plane. Studies used diverse protocols, instructions and parameters when assessing gait in AS patients.

CONCLUSIONS

Only few studies have assessed gait characteristics in patients with AS. Published data evidence that no consensus exists regarding gait analysis methods for patients with AS. However, published studies are encouraging as they provide us the opportunity to propose guidelines to improve the design and methodology for future studies on gait and AS.

CLINICALTRIAL

PROSPERO: CRD42018102540 and JMIR Res Protoc doi:10.2196/12470
Capturing At-Home Health and Care Information for Children With Medical Complexity Using Voice Interactive Technologies: Multi-Stakeholder Viewpoint (Preprint)
Authors: Sezgin Emre , Noritz Garey , Elek Alexander , Conkol Kimberly , Rust Steve , Bailey Matthew , Strouse Robert , Chandawarkar Aarti , von Sadovszky Victoria , Lin Simon , Huang Yungui
Published: April 2019

UNSTRUCTURED

Digital health tools and technologies are transforming health care and making significant impacts on how health and care information are collected, used, and shared to achieve best outcomes. As most of the efforts are still focused on clinical settings, the wealth of health information generated outside of clinical settings is not being fully tapped. This is especially true for children with medical complexity (CMC) and their families, as they frequently spend significant hours providing hands-on medical care within the home setting and coordinating activities among multiple providers and other caregivers. In this paper, a multidisciplinary team of stakeholders discusses the value of health information generated at home, how technology can enhance care coordination, and challenges of technology adoption from a patient-centered perspective. Voice interactive technology has been identified to have the potential to transform care coordination for CMC. This paper shares opinions on the promises, limitations, recommended approaches, and challenges of adopting voice technology in health care, especially for the targeted patient population of CMC.
Evaluation of the Acute Flaccid Paralysis Surveillance System in Polio-Free Jordan, 2012-2016: Retrospective Secondary Analysis (Preprint)
Authors: Zerriouh Fatima , Khader Yousef , Qasem Nabil , Abusal Kamel , Iblan Ibrahim , Ghaffari Layla , Abdallat Mohammed
Published: April 2019

BACKGROUND

As part of the polio-eradication strategy, the World Health Organization (WHO) has established a global acute flaccid paralysis (AFP) surveillance system. AFP surveillance has successfully helped Jordan achieve polio-free certification. However, there is a substantial risk of polio importation from neighboring countries including Syria and Iraq.

OBJECTIVE

This study aimed to evaluate the AFP surveillance in Jordan and identify areas that need improvement.

METHODS

This retrospective study is a secondary analysis of data that were routinely collected between 2012 and 2016 by Jordan’s Expanded Program on Immunization. The WHO’s minimum performance indicators were used to evaluate the AFP surveillance.

RESULTS

Cumulatively, 328 AFP cases had been reported. Almost half (n=168, 51.3%) of the patients were aged 1-5 years, and 55.8% (n=183) were male. All cases were discarded (classified as a nonpolio case). The most common cause of AFP was Guillain-Barre Syndrome (n=115, 35.1%). The annualized nonpolio AFP rate increased from 1.4/100,000 children below 15 years of age in 2012 to 4.3 in 2016. National and subnational sensitivities were not met in 2012 and 2013. Adequacy of stool specimens and timeliness of specimens arriving at and processed in the laboratory were constantly above the minimum target. Timeliness of the investigation met the expected target but with a decreasing trend. The nonpolio enterovirus isolation rate was below the target, except in 2016.

CONCLUSIONS

The AFP surveillance system in Jordan is performing well; however, additional efforts are needed to strengthen the subnational sensitivity. The cold chain from sample collection to laboratory testing has to be maintained to ensure the reliability of stool specimens required for isolation of the nonpolio enterovirus.
Making it RAIN: Using Remotely Accessible Instruments in Nanotechnology to Enhance High School Science Courses
Authors: Min Ashley , Ashcroft Jared , Monroy Joel , Wolf Vanessa , Lee Christina , Horton Josee , Ehrmann Robert , Rodriguez Brandon
Published: April 2019

The Remotely Accessible Instruments in Nanotechnology (RAIN) Network is a conglomerate of nineteen community colleges, four-year universities and high school sites that aims to enhance STEM learning by bringing advanced technologies to K-12 education. RAIN provides free remote access to instruments such as Scanning Electron, Atomic Force and Transmission Electron Microscopes, as well as Energy Dispersive and Infrared Spectroscopy. The following is a variety of experiments and an empirical formula lab that can be performed in a high school physical science or chemistry classroom that utilizes the RAIN Network.
ИЗРАЖЕНОСТ И КОРЕЛАТИ КОНФЛИКТА РОДИТЕЉСКИХ И ПОСЛОВНИХ УЛОГА РОДИТЕЉА
Authors: Ђорђевић Марија , Матејевић Марина
Published: April 2019

This paper addresses the issue of the intensity of the inter-role conflict regarding the parent and business roles and the relation between the conflict and variables: gender, level of education and type of work. The problem of the inter-role conflict is accessed through the famous model of job-family conflict, developed by Greenhaus & Beutell (1985), according to which the impact of work on family and vice versa consists of three subdimensions: time-based conflict, the conflict based on effort, strain and characteristics of persons and conflict based on the behaviour. This research was performed among 204 participants - working parents with at least one child between the age of three and sixteen, from Serbia. The obtained results show that the participants do not express conflict between the parent and business roles, while they reported a positive employment effects. So, it shows that the parents’ employment positively influences the family atmosphere. There were significant differences between the conflict based on strain, that were found between the male and female participants – the results showed a greater number of mothers who have conflict based on strain than the fathers. Also, differences were found regarding the parents’ level of education - the positive employment effect is greater among parents with higher levels of education than the parents with lower levels of education.
„СТАРОСТ” ПОЕТСКОГ ЛИКА СРБИНА ЈУНАКА И УЗРОК ЊЕГОВЕ ПОПУЛАРНОСТИ У ЈУЖНОСЛОВЕНСКОЈ НАРОДНОЈ ПОЕЗИЈИ
Authors: Шешум Урош
Published: April 2019

The paper deals with the period in time when a poetic character, bearing the title “ethnic Serb” as if it were his own personal name, was introduced into epic and lyric poetry of the South Slavs, and the cause of his vast representation in epic and lyric poetry in the area of today’s Macedonia, North Greece and West Bulgaria in the 19th century. The paper indicates towards a continued use of the ethnic Serb as an anthroponym in today’s West Macedonia between the 15th and 19th centuries and the popularity of poems about an eponymous hero in the same area. A hypothesis was therefore introduced claiming that before the 18th century he was a hero of the local folklore of this area, with poems describing him expanding to other regions over time.
МЕНТОРСКИ РАД У СРБИЈИ – КОНТУРЕ ЈЕДНЕ ТИПОЛОГИЗАЦИЈЕ
Authors: Шијаковић Тања
Published: April 2019

As a highly complex relational phenomenon, mentoring and practice which are jointly carried out by an intern and a mentor, attracted the attention of researchers in different fields. With the aim to draw attention to this part of the educational practice in our environment, we carried out a research which focuses on issues of internship and mentoring in education. Although our attention was focused primarily on the issues related to understanding the concept of internships and mentoring and how the offered solutions would reflect in the practice of interns and mentors, research has unexpectedly resulted in some additional findings – the possible types of mentoring in our educational context.Shown results were achieved after analysis of the transcribed material collected in individual interviews, conducted by ten mentors. All the discovered and different approaches to mentoring work are based on an analysis of responses and interpretations that were given by the mentors themselves, and related to: understanding the functions of mentoring; expectations from the interns; understanding the role of interns and mentors; understanding the process of learning and the importance of planning the work with interns. Interpreting the way mentors understand aforesaid and describing specific relation with their interns, we have selected mentors who have demonstrated a consistent linguistic experiential patterns and positions, mutually so different, that they can make the contours of different types of mentoring. In the paper these specific types are identified as: adhoc, formal and development mentoring.
PRIORITIZATION OF STRATEGIES FOR TOURISM DEVELOPMENT BY APPLYING A SWOT-SWARA ANALYSIS: THE CASE OF SOKOBANJA SPA
Authors: Popović Gabrijela , Milovanović Goran , Stanujkić Dragiša
Published: April 2019

This manuscript proposes the utilization of the SWOT-SWARA analysis for the prioritization of tourism development strategies. The applicability and simplicity of the proposed analysis is demonstrated by the example of the tourism destination of Sokobanja Spa in the Republic of Serbia. By using the SWOT analysis, three decision-makers defined the key sub-factors and development strategies, after which they performed the prioritization of the SWOT factors, sub-factors and strategies by applying the SWARA method. The final results are indicative of the following order of the proposed development strategies: ST1WT2SO1ST2SO2WO1WO2WT2. Applying the proposed strategies by following the given order will contribute to the improvement and further development of the tourism destination of Sokobanja Spa, which is the main goal of the performed analysis.
ЗНАЧАЈ РАЗВИЈАЊА ЛЕКСИЧКЕ КОМПЕТЕНЦИЈЕ НА СТРАНОМ ЈЕЗИКУ И УТИЦАЈ МАТЕРЊЕГ ЈЕЗИКА КОД МЛАЂИХ УЧЕНИКА
Authors: Šuvaković Aleksandra Branislav
Published: April 2019

The purpose of this paper is to point out the importance of learning several foreign languages at an early age, creating a solid basis for lexical competence which would in the next phase develop into linguistic, and finally into communicative competence. We will point out the theoretical basis of learning a lexicon of a foreign language, but also in what manner the mother tongue may influence this process and how. The results presented in the paper are a product of a two-year empirical research – a case study. The set goal has conditioned two hypotheses that we have confirmed, and which relate to achievements in lexical competence in a foreign language and a transfer that the mother tongue can cause. Analyzing the results, we concluded that an early exposure to foreign languages simultaneously enriches the lexical fund of both the mother tongue and all other languages known to the learner, in our case, the Italian language. In addition, learning foreign languages early, by developing lexical competence in the first place, leads to an improvement of cognitive characteristics of younger learners, the development of divergent thinking, acculturation and openness to new knowledge.
INDICATORS OF FRAUD IN FINANCIAL REPORTING IN THE REPUBLIC OF SERBIA
Authors: Dimitrijević Dragomir Slavoljub , Obradović Vladimir Milovan , Milutinović Sunčica
Published: April 2019

Companies can use various manipulative techniques when preparing general-purpose financial statements in order to present better financial position and better performance. Fraudulent financial statements can lead their users to wrong decisions and, consequently, cause big losses and distort confidence in the financial reporting system. Therefore, it is important to timely discover and prevent financial reporting frauds. Timely detection of fraud is one of the key tasks of forensic accountants, who should pay attention to fraud indicators, i.e. warning signs of fraud. Warning signs are not evidence of fraud but point to the need for a more detailed investigation. The aim of the research in this paper is to examine whether there are warning signs and to understand the degree of fraud risk in financial reporting by analyzing financial statements of companies in the Republic of Serbia. The research is conducted on a sample of 42 companies. By applying the Beneish model, we find that the general fraud risk is not insignificant. Borrowing activities of companies are identified as a significant source of this risk, while forensic accountants should pay special attention to income recognition and accrual items, i.e., items related to recognition of income and expenses before or after cash inflows or outflows, including depreciation. Higher risk of fraud is identified in manufacturing companies and financial institutions than in trade and service companies. The research results indicate the need to strengthen the mechanisms of financial reporting control in the Republic of Serbia.
HYBRID GENESIS OF INFORMATION OPERATIONS IN CYBERSPACE
Authors: Mitrović Miroslav
Published: April 2019

Contemporary global security environment could be labeled as complex, dynamic, multidimensional and ‘’beyond limits’’ of conventional understanding of Warfare. Diversity of threat forms and its interactions and non-conventionality contribute that most of the actual security crises and conflicts are marked as Hybrid security endangering, or Hybrid Warfare. Globalised tehnology introduce new ‘’battlefild’’ in global digital arena. Massive application of information and communication technology has brought about new risks and threats represented by physical and software related dangers to critical information infrastructure and cyberspace that are of relevance to the nation and its security. In same hand, wolnurability and inportance of Cyber space tends to provoke necessity for ultimate resilaince copabilities against ataks and informational warfare. Hybrid form and asimetrical nature of endangerment of Cyber space which is crutial for national defence copabilites, rised analiticial approach to the political, security and organizational forms as well as clasification of threats in cyber space which were elaborated in this paper. Authors’ contribute to the understunding of threats in Cyber secyrity arena, trough analyses of China PLA approach to the subject. In addition, unique contribution is given with analyses of Cyber-Information Warfare during 1999 NATO aggression to the Federal Republic of Yugoslavia.
ПОКРЕТАЊЕ ПОСТУПКА НОРМАТИВНЕ КОНТРОЛЕ ПРАВА У РЕПУБЛИЦИ СРБИЈИ
Authors: Pásztor Bálint
Published: April 2019

The author of the article analyzes the specificities of the normative control of the law, i.e. the procedure of assessing the constitutionality and legality of the law in the Republic of Serbia, with the aim of detecting historical and legal preconditions of the effective functioning of the rule of law. The historical perspective of the development of the constitutional judiciary in the Socialist Federal Republic of Yugoslavia and the Republic of Serbia, as well as the analysis of the experiences of various systems of control of constitutionality and legality, open the contextual, scientific-historical and pragmatic dimensions of understanding. The specificity of the system of normative control is reflected in its triplicity, meaning that three institutes are known that characterize different procedural possibilities (to initiate the process of assessing the constitutionality and legality of general acts). The paper is written in order to point out the dichotomy of the proposal and initiative of the procedure of the assessment of constitutionality and legality, as well as the advantages and disadvantages of the ex officio procedure. Furthermore, the author wanted to point out the essential and procedural differences between the proposal, the initiative and the constitutional complaint, especially analyzing the purpose of retaining the institute of the initiative in the light of the existence of the constitutional complaint and the fact that the initiative does not imply the automation of the initiation of proceedings. The dilemma that the article opens concerns the possibility that in the case of abolishing the initiative as an institution accessible to all, is it possible to preserve the democratic culture and the participation of citizens, furthermore is it possible to abolish the fundamental institutional values and freedoms of a legal state and the rule of law? The paper opens other issues of importance for the establishment of an effective constitutional architecture that concern: the width of the circle of authorized proposers of normative control before the Constitutional Court; the dual role of the constitutional judiciary: on the one hand protection of the Constitution, constitutionality and legality, on the other hand effective protection of human and minority rights and freedoms.
Definiendo la pedagogía habilitada para REA
Authors: Wiley David , Hilton John
Published: April 2019

El término pedagogía abierta se ha utilizado de diferentes maneras durante las últimas décadas. En los últimos años, su uso también se ha asociado con los recursos educativos abiertos (REA). La amplia gama de definiciones de pedagogía abierta, junto con su superposición semántica con otro término no especificado, prácticas educativas abiertas, dificulta conducir investigaciones sobre el tema. Al hacer esta afirmación no se pretende poner en duda la efectividad potencial de los muchos enfoques de la pedagogía etiquetados como abiertos. En este artículo, más que intentar defender una definición canónica de pedagogía abierta, se propone un nuevo término, pedagogía habilitada para REA, definido como el conjunto de enseñanza y aprendizaje que sólo son posibles o prácticos en el contexto de los permisos 5R característicos de los REA.  Proponemos criterios utilizados para evaluar si una forma de enseñanza constituye una pedagogía habilitada por REA y analizamos varios ejemplos de pedagogía habilitada para REA con estos criterios.

 

Este artículo ha sido reproducido de la revista The International Review of Research in Open and Distributed Learning (IRRODL), 19(4), con la licencia Creative Commons Attribution International 4.0. © 2018. Autores: David Wiley y John Hilton.
Aula Virtual como herramienta en la enseñanza del idioma inglés en el Nivel Medio Superior
Authors: Cruz Ramírez Juan Baltazar
Published: April 2019

El propósito de este trabajo es analizar cualitativamente si la enseñanza del inglés en un aula virtual, mediante representaciones escritas, auditivas, gráficas, analíticas y verbales y con un enfoque interactivo, mejora los resultados obtenidos en el marco de la comprensión de los conceptos analizados en la práctica del idioma inglés, comparados contra el exclusivamente escrito, de acuerdo con los fundamentos teóricos sustentados en la Teoría de Representaciones Semióticas. El Aula Virtual se desarrolló mediante el uso del Sistema E+ versión LYNX como una solución integral para el diseño de aulas virtuales, basado en código libre como una plataforma de software pensada para potenciar, facilitar y administrar eficientemente el proceso de enseñanza/aprendizaje. Esta propuesta está enfocada en la enseñanza del inglés en el Nivel Medio Superior en Modalidad Virtual. De manera cualitativa se analizó una muestra de 34 estudiantes (24 hombres y 10 mujeres) del Nivel Medio Superior, quienes cursaron la materia de Inglés I en modalidad virtual en el Sistema de Universidad Virtual de la Universidad Autónoma de Guerrero, separados en dos grupos, uno que se consideró de control con 21 aprendientes (15 hombres y 6 mujeres), que utilizó únicamente una Hoja de Trabajo para contestar de manera escrita una entrevista laboral en inglés y otro grupo que podemos considerar como experimental, que trabajó con el Aula Virtual y estuvo conformado por 13 aprendientes (9 hombres y 4 mujeres). No se encontró un equilibrio entre la integridad y exactitud de las respuestas del grupo de control que utilizó exclusivamente la versión escrita de la hoja de trabajo, como sí se encontró en el trabajo del grupo experimental, después de la lección interactiva en el aula virtual.
Estrategias metacognitivas aplicadas en la asignatura de Desarrollo del potencial humano
Authors: Mendoza Ruiz María Guadalupe , Gutiérrez Gómez Evelyn
Published: April 2019

La presente experiencia académica tiene por objetivo exponer cómo, a partir de asignaturas que pertenecen al campo disciplinar de Desarrollo Humano, el  alumno realizará un proceso reflexivo a través de distintas estrategias de aprendizaje, como el cuadro SQA o PNI, el análisis FODA, las líneas de tiempo, la resolución de casos de vida y los cuadros RA-P-RP. Dichas estrategias le permitirán desarrollar un proceso metacognitivo que le ayude a realizar una introspección acerca de un proyecto de vida, el cual le ayudará a concluir el nivel medio superior, disminuyendo, así, la deserción escolar en el Bachillerato Universitario a Distancia.
Modelos de mediación docente en el Bachillerato Virtual de la Universidad Autónoma de Sinaloa
Authors: De Loza Dones Daniel Emmanuel , Pastor Angulo Martín
Published: April 2019

El presente trabajo es parte de una investigación realizada en el Bachillerato Virtual de la Universidad Autónoma de Sinaloa. Se aborda la propuesta de cuatro modelos para el análisis de la mediación docente, así como los resultados sobre la tendencia de los docentes hacia los modelos de mediación. El abordaje teórico se realiza desde un posicionamiento sociocognitivo, donde se plasma al docente como un agente mediador que interviene desde distintas perspectivas en los procesos de construcción del conocimiento del alumno. Se obtuvo una participación del total de la planta docente activa en el primer y tercer semestre del ciclo escolar 2017-2018. Los resultados muestran una tendencia hacia el modelo de mediación complejidad con una predominancia en 6 de los 23 criterios establecidos para el análisis. Se concluye que el Bachillerato Virtual de la UAS posee 14 criterios en los modelos de mediación simplicidad e individualidad, los cuales pueden ser atendidos para lograr prácticas más complejas de mediación que propicien la autonomía, sociabilidad, metacognición y aprendizajes significativos en los procesos de intervención del docente.
Estrategias para disminuir la deserción escolar en el Bachillerato en Línea de la Universidad Autónoma de Yucatán
Authors: Peña Quintal Estefani Concepción , Rodríguez Góngora Fátima Concepción
Published: April 2019

El Bachillerato en Línea de la Universidad Autónoma de Yucatán está comprometido con la educación de sus estudiantes, por lo que, a partir de lo observado en el último ciclo escolar, se han implementado diversas estrategias con base en los conocimientos previos en los que intervienen los asesores, tutor-orientador y estudiantes, con la finalidad de que los últimos terminen sus estudios satisfactoriamente. Dichas estrategias son abordadas desde diversas vertientes tales como seguimiento de estudiantes, asesorías en línea y presencial, entre otras.

Cabe recalcar que las estrategias son un factor clave, ya que de esto depende mucho que los estudiantes concluyan exitosamente sus estudios; tanto, que hasta el momento nos ha permitido obtener enormes beneficios tales como que estamos más cercanos a los estudiantes y que tenemos un mayor control con la situación de cada uno.
Experiencias sobre la transformación de estrategias de retención en la modalidad virtual
Authors: Silva Bonilla Olga Esther , Alarcón Paredes Diego , Romero Bonilla Jorge Roberto
Published: April 2019

La educación tradicional tiene cada vez más problemas para dar respuesta a las necesidades que demanda la sociedad actual; por ello, la educación virtual es una modalidad de estudio que surge como una alternativa para extender la oferta educativa y dar solución a los tiempos que actualmente se viven.

El estado de Guerrero se caracteriza por ser un lugar con múltiples problemáticas de carácter económico, político, social y educativo; por tal motivo, la Universidad Autónoma de Guerrero (UAGro), cuya función principal es ayudar al progreso de la sociedad guerrerense, se propuso transformar el modelo educativo. En el año 2013, la UAGro incorporó a la Coordinación General de Educación Virtual (CGEV), y en 2015, el H. Consejo Universitario aprobó su transformación a Sistema de Universidad Virtual (SUVUAGro), cuyo propósito es implementar y promover la modalidad de educación a distancia con el objetivo de desarrollar el potencial de las personas a través de ambientes virtuales de aprendizaje.

El presente artículo centra su atención en compartir la experiencia que ha tenido el Departamento de Control Escolar y Seguimiento de Estudiantes (DCEySE), de la Coordinación General de Educación Virtual, de la Universidad Autónoma de Guerrero, en relación con el proceso que ocurre en los distintos momentos por los que pasan los estudiantes del Bachillerato General en modalidad virtual.
Una mirada al interior de Michigan Virtual: entrevista a Jamey Fitzpatrick
Authors: Vadillo Bueno Guadalupe
Published: April 2019

En esta entrevista, el presidente y director ejecutivo de Michigan Virtual, una escuela pública de modalidad en línea de este estado de la Unión Americana, describe su historia y funcionamiento, así como sus retos y las soluciones que han desarrollado para cumplir con sus tres funciones fundamentales: aportar cursos suplementarios a estudiantes en el estado, ofrecer formación profesional a maestros y administradores, y generar investigación sobre aprendizaje en línea e híbrido. Señala las tres grandes aportaciones que ha hecho esa institución y explora futuros para la educación.

 

Para visualizar el video vaya al siguiente enlace: https://youtu.be/VUZyL6vtmgE
Modelo TPACK: ¿Medio para innovar el proceso educativo considerando la ciencia de datos y el aprendizaje automático?
Authors: Salas-Rueda Ricardo Adán
Published: April 2019

Objetivo - analizar el diseño y uso de la Aplicación Web Sobre la Probabilidad Condicional (AWSPC) en el proceso educativo considerando el modelo Technological Pedagogical Content Knowledge (TPACK), la ciencia de datos y el aprendizaje automático.

Método - se realizó una investigacion mixta para evaluar el impacto de la AWSPC en el campo de la estadística. La muestra está compuesta por 61 alumnos que cursaron la asignatura: Instrumentación Estadística para los Negocios, durante el ciclo escolar 2018.

Resultados - los resultados del aprendizaje automático (50%, 60% y 70% de entrenamiento) permiten afirmar que la aplicación awspc mejora el proceso de enseñanza-aprendizaje. Por otro lado, la ciencia de datos establece diversos modelos predictivos sobre el uso de la aplicación AWSPC en el campo educativo (técnica árbol de decisión).

Limitaciones - la aplicación AWSPC presenta la simulación de la probabilidad condicional y de intersección sobre el suministro de piezas. Los contenidos de esta herramienta tecnológica se encuentran en español, por lo que para futuras investigaciones se pueden diseñar y construir sistemas web educativos que presenten los contenidos en diferentes idiomas y se utilice diversos ejercicios durante las simulaciones. Por ejemplo, el uso de la inteligencia artificial en el contexto educativo permitiría la personalización de los temas.

Principales hallazgos - el modelo TPACK permite la construcción de nuevas herramientas digitales como la aplicación AWSPC por medio de los conocimientos tecnológico, pedagógico y disciplinar. Se recomienda el uso del modelo TPACK en los diferentes niveles educativos para mejorar las condiciones de enseñanza-aprendizaje.
Análisis del genoma de Pycnoporus cinnabarinus mediante electroforesis de campo pulsado
Authors: Cifuentes Víctor , Martínez Claudio
Published: April 2019

En el presente trabajo se describe la separación óptima de moléculas de DNA cromosómico intacto del hongo filamentoso Pycnoporus cinnabarinus, mediante eléctroforesis de campo pulsado usando un sistema de contorno de campo eléctrico homogéneo (CHEF), con un electrodo hexagonal.Se estudió una serie de condiciones experimentales en las cuales se hizo variar la duración del intervalo de tiempo en cada dirección del campo y el tiempo total de la corrida.De esta manera fue posible separar el DNA cromosómico de P. cinnabarinus en cuatro bandas que, dependiendo e las condiciones de electroforesis,pueden ser resueltas por lo menos en siete bandas. Utilizando los patrones de migración del DNA cromosómico de Saccharomyces cerevisiae y Schwanniomyces occidentalis comoestándar, estimamos que los tamaños moleculares del DNA cromosómico de P. cinnabarinus oscilan entre 1.9 y 2.5 megabases (Mb).
Hongos filamentosos aislados desde el suelo y el agua en la playa de Boa Viagem (Recife, Brasil)
Authors: De Araújo Pinto Isabel María de Araújo Pinto María , Cavillcánti M. A.Q. , De Oliveira Passavante José Zanon. de Oliveira Passavante Zanon
Published: April 2019

Se investigó la presencia de hongos filamentosos en el suelo y en las aguas de la playa de Boa Viagem, Recife, Pernambuco, Brasil. Se aisió un total de 10.894 colonias de hongos pertenecientes a 49 géneros y 115 especies, mayoritariamente Deuteromycetes. Los generos Aspergillus y Penicillium fueron los dominantes en ambos sustratos.