bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating Learning Management Systems in University: Evidence in University in North Sulawesi
Authors: Maramis Glenn D P
Published: March 2024

Learning management systems (LMS) have been established at universities around the world including at Manado State University to connect students and faculty without the confines of a traditional classroom. It is a digital software environment designed to manage user engagement and provide learning content and resources to students. The aim of this study is to evaluate the use of learning management systems in universities. The method used in this study is the combined methods we used, namely library research and surveys. The library research method also uses secondary data collected from informative articles, books, and magazines. The results of this study found that the LMS used in universities is generally good, this is because the LMS system has been introduced and teachers must use it in daily lectures as well, it is very important to determine the feedback from students as LMS users. Previous studies have demonstrated varying understandings of the impact of implementing LMS in higher education in universities around the world. Therefore, this article provides some insights into the Impact of Utilizing E-learning Technology or LMS. This study concludes that the use of post-covid-19 LMS has shown a fairly good increase both for providers of learning content, namely teachers and system managers, and on the user side, namely students so that learning activities at universities have experienced quite an increase.
How Information Technology Affects Decision Making
Authors: Tiwow Gilly Marlya , Rawis Joulanda A.M. , Tambingon Henny N. , Kambey Joseph
Published: March 2024

One of the most important contributions of information technologies to the leaders was to enhance the performance level with the help of alternatives provided by information technology. Information technology provided support to the decision-making process. The main important point in the decision-making was giving the most appropriate and best decisions. This research was conducted to analyze the effect of Information technology on Junior high school principals in Tomohon City. The study was conducted with a quantitative approach using a simple regression technique. The result shows that there was a significant impact of Information technology on principal decision-making. Therefore, suggested that education institution leaders enhance the maximization of Information Technology.
System Leadership in Continuing Education in Digital Era Industry 4.0
Authors: Ebe Lord Steward , Rawis Joulanda A.M. , Tambingon Henny N. , Kambey Joseph
Published: March 2024

This research aimed to describe education leadership in continuing education by building the system leadership as a reform system in the professional and modern era. This research is descriptive qualitative research using a social history approach. The design research method was carried out in four phases: data collection, data display, conclusions, and data condensation. The result of this research shows that all education leaders in all levels should be building a system leadership as a reform system for the generation in the modern era to education for sustainable development in Papua.
The Leadership and Access to Technology-Based Health Information as A Public Health Promotion Strategy
Authors: Lolong Rima Fien , Rawis Joulanda A.M. , Tambingon Henny N. , Kambey Joseph
Published: March 2024

This article discusses the role of leadership in promoting public health through access to technology-based health information. With the increasing use of technology in healthcare, it is important to ensure that individuals have access to accurate and reliable health information. The article argues that effective leadership is necessary to facilitate the dissemination of health information through technology and to ensure that individuals have the skills and resources to access this information. The article also highlights the importance of addressing barriers to access, such as lack of internet connectivity and limited digital literacy. The article concludes that by prioritizing access to technology-based health information and fostering effective leadership in this area, public health promotion efforts can be strengthened and improved
The Role of Information Technology in Z Generation Behavior Change in Dealing with Conflict
Authors: Sumolang Nortje
Published: March 2024

Developments in information technology such as the Internet, social media, and mobile devices have provided broad and immediate access to information and social interaction. However, the impact of information technology on the behavior of the Z Generation in dealing with the conflict still needs to be studied in depth. This study aims to explore the role of information technology in changing the behavior of the Z Generation in dealing with conflict. The Z Generation, which consists of individuals born between 1995 and 2010, grows and develops amidst the rapid advances in information technology. This study will use a qualitative approach by collecting data through in-depth interviews and participatory observation. Research participants will consist of Z Generation individuals who actively use information technology in their daily lives. This study will analyze the role of information technology in changing the behavior of the Z Generation in dealing with conflict, both in personal, social, and environmental contexts. Factors such as fast access to information, the influence of social media, and the ability to communicate virtually will be explored in relation to changes in the behavior of the Z Generation. It is hoped that the results of this research will provide better insight into how information technology influences the way Z Generation deals with conflict, as well as the implications of the change in behavior. The results of this research are expected to contribute to our understanding of how information technology can be used effectively in supporting the social and personal development of the Z Generation in dealing with conflicts in the digital era.
The Role of m-Learning in Project-Based Learning Models in Elementary Schools
Authors: Mamuaja Marlin Penina , Rawis Joulanda A.M. , Lengkong Jeffry Sony Junus , Rotty Viktory Nicodemus Joufree
Published: March 2024

Project-based education has become an increasingly popular approach in today's education system, especially at the primary school level. Project-based learning allows students to engage in real activities that involve exploring, collaborating, and applying the concepts they learn in real-life contexts. In the digital era that continues to grow, m-Learning (learning via mobile devices) has become an important instrument in helping educators implement project-based learning models in elementary schools. This study aims to investigate the role of m-Learning in a project-based learning model in elementary schools. This study will involve collecting qualitative and quantitative data through classroom observations, teacher interviews, and student surveys. The research focus will cover several important aspects, including (1) The use of m-Learning in providing relevant and varied learning resources to students, (2) The effectiveness of m-Learning in increasing student motivation and involvement in project-based learning models, ( 3) The impact of m-Learning on students' collaborative skills and creativity in developing their projects, (4) Teachers' perceptions of the use of m-Learning in project-based learning models. It is hoped that the results of this research will provide a better understanding of the role of m-Learning in the context of project-based learning in elementary schools. The findings of this study can provide insight to educators, teachers, and decision-makers in the field of education to optimize the use of technology in an effort to improve the quality of learning in elementary schools.
Effective Strategies using Digital Literacy for Empowering Critical Thinking in Higher Education
Authors: Manggopa Hiskia Kamang , Kumampung Deislie R. Henrieta
Published: March 2024

In the digital era, digital literacy skills have become important in equipping students with the skills to participate actively in an increasingly connected and complex society. Likewise, critical thinking skills are essential in helping students develop deep understanding, good analysis, and evaluation of the information they encounter. This study aims to investigate effective strategies for using digital literacy to empower critical thinking skills in higher education. This research will adopt a qualitative approach using the case study method in several higher education institutions. Data will be collected through in-depth interviews, observation, and document analysis related to digital literacy strategies in the learning environment. Next, the data will be analyzed using a content analysis approach to identify which strategies most effectively empower students' critical thinking skills. It is hoped that the results of this study will provide in-depth insight into how digital literacy can be properly integrated into the higher education curriculum to stimulate students' critical thinking skills. The implication of this research is to provide practical guidance to educators, lecturers, and decision-makers in higher education institutions to design learning strategies that support the development of digital literacy and critical thinking. In addition, this research can also contribute to further research in the field of digital literacy and higher education. With a stronger focus on incorporating digital technologies in higher education, it is hoped that this research will provide valuable directions for the development of relevant and innovative curricula, which in turn will help produce graduates who are not only technically proficient but also able to think critically in facing complex modern world challenges.
Implementation of School Management Information Systems at Vocational School State I Tomohon
Authors: Kamu Israel Yonatan Fredrik , Rompas Parabelem Tinno Dolf , Parinsi Mario Tulenan
Published: March 2024

This research discusses the implementation of the School Management Information System (SIMS) at SMK Negeri 1 Tomohon using the Rapid Application Development (RAD) method. School management, as a process of planning, organizing, directing, and controlling, is carried out by the school principal and his staff to achieve educational goals. The main goal of school management is to create an effective and efficient learning environment. Information systems, as entities with human, hardware, software, procedures, and data components, aim to collect, store, process, manage, and convey relevant information. SMK Negeri 1 Tomohon, as a vocational school in North Sulawesi, faces management challenges due to the use of conventional systems. Processes such as recording grades, registering students, compiling schedules, and collecting data on school fee payments often take time and are difficult. Therefore, this research is focused on implementing a School Management Information System using the programming languages PHP, HTML, CSS, and MySQL, with users consisting of Admin, Teachers, and Students, and using the RAD method. This research identifies problems in data management and school administration which are still manual, resulting in inefficiencies and potential errors. SIMS succeeded in making a positive impact with a structured interface, allowing easy access to information on grades, schedules, and learning activities. SIMS also facilitates systematic monitoring of student and teacher performance. This research concludes that SIMS can be an effective solution to support educational management at SMK Negeri 1 Tomohon with the potential for wider application in other school environments.
Contribution of K3 Implementation,the Role of Industrial Work Practice Mentoring and the Value of Productive Training Courses Towards Industrial Work Practice Results of Informatics Engineering Students Department Cokroaminoto Vocational School,Kotamobagu
Authors: Mamonto Mutahir , Rompas Parabelem Tinno Dolf , Olii Djami , Oroh Rolly Robert , Rotty Viktory Nicodemus Joufree
Published: March 2024

This research aims to determine the contribution of the implementation of K3, the role of industrial work practice supervisors, and the value of training courses on the results of industrial work practices both individually and collectively. The method used in this research is a quantitative method with data collection techniques used are questionnaires and documentation, while the data analysis technique used is multiple regression analysis with the help of SPSS 24. The results of the research show that there is a contribution from the application of occupational safety and health to the results of industrial practice among Informatics Engineering students at Cokroaminoto Vocational School. The contribution of the application of occupational safety and health to the results of industrial practice is 73.5%. There is a contribution from the role of industrial supervisor teachers to the results of industrial practice for Informatics Engineering students at Cokroaminoto Vocational School. The contribution of the role of industrial supervising teachers to the results of industrial practice is 72.6%. There is a contribution of the value of students' productive training courses to the results of industrial practice for students in the Informatics Engineering Department at Cokroaminoto Vocational School. The contribution of the role of industrial supervisors to the results of industrial practice is 74.4%. There is a contribution from the application of occupational safety and health, the role of industrial supervisors, and the value of students' productive training courses to the results of industrial practice together. The contribution of the application of occupational safety and health, the role of industrial supervisors, and the value of students' productive training courses to the results of industrial practice together is 75.3%, while the remainder is influenced by other variables that are not studied in this research.
Development of Interactive Multimedia for Informatics Learning in Manado State 6 Junior High School
Authors: Bahrun Lusi Maryana , Rompas Parabelem Tinno Dolf , Oroh Rolly Robert
Published: March 2024

The development of the Industrial Revolution 4.0 has brought changes, where students can take advantage of technological advances in this revolution by accessing the internet to look for learning resources either through websites or YouTube. This research aims to (1) develop interactive multimedia learning in informatics learning for class VII students, (2) determine the feasibility of interactive multimedia for class VII informatics learning (3) find out students' responses regarding interactive multimedia in learning. This interactive multimedia development uses the Research and Development (R&D) method, and the APPED development model with steps (1) analysis and initial research, (2) design, (3) production, (4) evaluation, and (5) dissemination. Respondents to research on the development of interactive multimedia for informatics learning were class VII of SMP Negeri 6 Manado. The results of the research that has been carried out show that: (1) interactive multimedia on computational thinking material was created and developed using Google Sites. (2) The results of the assessment of the feasibility of learning multimedia obtained a percentage of feasibility in alpha testing, namely the assessment from material experts was 82.50% categorized as very feasible, the assessment from media experts was 91.25% categorized as very feasible, beta testing with assessments from average users feasibility, namely 85.77%, falls into the very feasible category. (3) Respondents' comments regarding this multimedia product were very diverse, namely suggestions for improving this interactive multimedia and responses that this interactive multimedia was needed for learning activities. Based on the respondents' responses and the assessment results from the questionnaire, interactive multimedia is used and needed by students in learning at SMP Negeri 6 Manado.
Evaluation of the Job Training Policy Implementation Process at the Manado City Manpower Office in IT Perspective
Authors: Pulukadang Raisha A.M. , Langkai Jeane E. , Tumbel Goinpeace H.
Published: March 2024

Implementation of training programs Work based on the Minister of Manpower Regulation Number 11 of 2013 concerning Guidelines Maintenance System Training National Work. Implementation of training programs carried out by the Manado City Employment Service experienced several obstacles, such as unemployment data on the same with existing real data. Study This uses the theory implementation of public policy. Objective study This is to know How the implementation of training programs is suitable to work with the needed company at the Manado City Employment Service. Study This use method studies qualitative descriptive. Data was obtained through observations, interviews, as well as documentation. Research results This discloses that evaluation of implementation programs policy training Work at the Manado City Employment Service is feasible next However with several repairs like providing more facilities sufficient to do so complete lack of maintenance training, adding source Power teacher or instructor Training for implementation training can walk in a way maximum, as well increase Work The same with companies related for help absorption of alumni participants training to the world Work.
Implementation of Supervision of Development Planning Using and Impact of Information Technology at the Office of Bappeda, Southeast Minahasa District
Authors: La Abu  , Masengi Evi E. , Mamonto Fitri H.
Published: March 2024

This research discusses the supervision, and planning, development of the Development Planning Agency (BAPPEDA) Office Southeast Minahasa District. This study aims first, to know and analyze as well as illustrate planning development in the district of Southeast Minahasa. Second, that is a known and analyzed factor determinant of planning development in the Southeast Minahasa district. The type of study is qualitative. The informant main is the Head of the District Development Planning Agency (Bappeda) Southeast Minahasa. Besides That, informant other that is functional nor Apparatus State Civil Service (ASN) in scope Bappeda Regency Southeast Minahasa, head village, Representative Body Village (BPD), figure community, youth and women representatives in the District Ratahan and East Ratahan Southeast Minahasa Districts. Data was obtained through interviews, observation, and documentation. Next, this research analyzed with a technique that the validity of data is based on the belief that with criteria This level existing beliefs already true, That is, stage This part from the validation process. Results of the research show that BAPPEDA supervision in planned programs is Still not enough stable. BAPPEDA still faces challenges in the supervision of planned programs related to development. The challenge in system BAPPEDA's planning lies yet effectiveness supervision, esp related to the extent of the planned programs following the plan beginning. Some of the programs it turns out Not yet following plans that have been set initially. One suggestion is an implementation of e-supervision in planning to get it held in real time.
Development of Learning Models in Core Competency Practice Courses Department of Mechanical Engineering Education Manado State University
Authors: Mumek Fillyen , Oroh Rolly Robert , Tamba Ibadja P.
Published: March 2024

The learning process obtained from universities to develop students' soft skills is also influenced by practical experience in the field. To develop soft skills in students, they have been given theories and practices that support the lessons in higher education, so that students have experience that can be used as a basis when entering the world of work. This research aims to develop a practical learning model in the Department of Mechanical Engineering Education, Manado State University. This research is developing research to develop a practical learning model. The online practice development model uses six interactions, namely interactions between students and lecturers, students with material, lecturers with material, students with students, lecturers with other lecturers, and material with material, through synchronous/asynchronous media. The results of this research show that the product developed is very suitable to be implemented to support online practical learning for core courses in higher education. This research has produced an online learning model for core subject practice with a flexible blended learning strategy at a low cost for students of the Mechanical Engineering Education Study Program. The resulting conclusion is that this model has the advantage of being able to create an online collaborative work environment. Validation by experts is carried out qualitatively and quantitatively.
The Influence of Instagram Social Media and Creativity on Learning Outcomes to Design Party Clothes at State 3 Vocational School Manado
Authors: Langguna Ayu Patricya , Daud Metsi , Olii Djami , Rompas Parabelem Tinno Dolf
Published: March 2024

This research aims to: 1) Find out the creativity in designing party clothing before using Instagram social media for students in SMK NEGERI 3 Manado. 2) Knowing the creativity in designing party clothes after using social media Instagram for students in SMK NEGERI 3 Manado. 3) Knowing the influence of the use of social media Instagram and creativity on student learning outcomes in designing student party clothing at SMK NEGERI 3 Manado. The sampling technique in the research was a saturated sample consisting of 35 students. Validity The instrument uses this validity with valid results. The reliability of the instrument using Cronbach's Alpha was 0.93 and 0.88. The normality test uses Kolmogorov-Smirnov with values 0.657>0.224 and 2.619>0.224. The linearity test obtained Y=42.886723 and Y=35.05175+0.598818. Hypothesis testing produces P-Value> 0.05 so Ho is accepted and Ha is rejected. Research results show: 1) Creativity in designing party clothes before using Instagram social media was an average of 70 in the less creative category. 2) Creativity in designing party clothes after using social media Instagram averaged 86 in the creative category. 3) The influence of the use of social media Instagram and creativity on student learning outcomes in designing party clothing can be seen in the increase in students' report card scores, which before use averaged 70 and after use averaged 85. Based on the results of the hypothesis test, it was stated that there was an influence.
Pengembangan Sistem Rekomendasi Berbasis Kecerdasan Buatan Untuk Meningkatkan Pengalaman Pengguna Di Platform E-Commerce
Authors: Didi Riswan  , Heri Eko Rahmadi Putra  , Risfan Nazar Saputra
Published: March 2024

Tujuan penelitian ini adalah untuk mengembangkan sistem rekomendasi berbasis kecerdasan buatan (AI) yang dapat meningkatkan pengalaman pengguna dan konversi penjualan di platform e-commerce. Permasalahan utama dalam penelitian ini adalah kebutuhan akan sistem rekomendasi yang dapat menyajikan rekomendasi produk yang lebih relevan dan personal kepada pengguna, sehingga dapat meningkatkan kemungkinan konversi penjualan dan memperkuat hubungan antara platform dan pembeli. Metode penelitian yang digunakan mencakup analisis data menyeluruh untuk memahami preferensi dan perilaku pengguna. Selain itu, model rekomendasi berbasis kecerdasan buatan dibuat dengan menggunakan teknik pengajaran mesin dan analisis data untuk memberikan pengalaman berbelanja yang lebih memuaskan bagi pengguna. Hasil penelitian menunjukkan bahwa sistem rekomendasi berbasis AI dapat meningkatkan pengalaman pengguna dengan menyajikan rekomendasi produk yang sesuai dengan minat dan kebutuhan pengguna. Selain itu, sistem ini berhasil meningkatkan konversi penjualan dengan mengoptimalkan strategi pemasaran dan memberikan manfaat operasional dalam bentuk efisiensi kerja. Oleh karena itu, penelitian ini membantu memahami peran sistem rekomendasi
Perancangan Sistem Informasi Manajemen RT/RW Pada Dusun II Sukamaju Berbasis Web
Authors: Yusuf Siregar Raja , Aldito Fayyadh Yustihar  , Akbar  , Olivia Maylina
Published: March 2024

Perancangan Sistem Informasi Manajemen RT/RW Berbasis Web merupakan sebuah solusi inovatif untuk mengatasi masalah kompleksitas dan kurangnya efisiensi dalam pengelolaan informasi di tingkat unit pemukiman RT/RW. Masalah yang diteliti meliputi keterbatasan aksesibilitas, penyimpanan data yang tidak efisien, dan kurangnya koordinasi antara warga dan pengurus RT/RW. Dalam penelitian ini, kami merancang dan mengimplementasikan sebuah sistem informasi manajemen berbasis web yang memungkinkan para pengurus RT/RW untuk mengelola informasi dan berkomunikasi dengan warga secara efektif. Sistem ini menyediakan berbagai fitur seperti database anggota warga, pengarsipan data, jadwal kegiatan, pemberitahuan, dan forum diskusi. Dalam perancangan sistem ini, kami menggunakan pendekatan pengembangan perangkat lunak berbasis web yang mencakup analisis kebutuhan, perancangan sistem, pengembangan aplikasi, dan uji coba. Kami juga menerapkan teknologi terkini dalam pengembangan web seperti HTML, CSS, dan basis data MySQL untuk memastikan keamanan dan skalabilitas sistem. Dengan implementasi sistem ini, diharapkan akan terjadi peningkatan efisiensi dalam pengelolaan informasi dan koordinasi antara pengurus RT/RW dan warga. Warga dapat mengakses informasi terkini, berpartisipasi dalam forum diskusi, dan memberikan masukan kepada pengurus. Pengurus RT/RW dapat mengelola data dengan lebih baik, mempercepat proses administrasi, dan mengoptimalkan pemberian pelayanan kepada warga. Penelitian ini memberikan solusi konkret untuk meningkatkan kualitas pengelolaan RT/RW dengan memanfaatkan teknologi informasi. Diharapkan sistem ini dapat diadopsi oleh banyak unit pemukiman RT/RW untuk mencapai tujuan yang sama, yaitu meningkatkan transparansi, partisipasi, dan efisiensi dalam pengelolaan komunitas setempat.
Historien om en billigbogsserie
Authors: Handesten Lars
Published: March 2024

Anmeldelse af: Felix Rothstein: Billigbog og højkultur – Gyldendals Bekkasinbøger. Bogvennen 2021. Forening for Boghaandværk.
Litteratursociologi, topologi og digitale metoder
Authors: Lohfert Jørgensen Jens
Published: March 2024

From a general literature sociological point of view that understands literature as source to an investigation of the history of emotions, this article discusses the possibilities offered by digital methods for composing a topology of apathy in Scandinavian literature of Decadence, to investigate the dissemination of the notion in the period.
Planetens floder
Authors: Damgaard Hansen Malte
Published: March 2024

By examining river motifs in the works of Jean-Antoine de Baïf, Michel de Montaigne, and Samuel de Champlain, this article discusses rivers in the French Renaissance as a destabilizing figure, which questions human position within a nonhuman environment.
Tiltrædelsesforelæsning: Arrival of the fittest
Authors: Rytter Mikkel
Published: March 2024

Lettere redigeret tiltrædelsesforelæsning ved Mikkel Rytter, Afdeling for Antropologi, Aarhus Universitet
Forfatterliste
Authors: Temaredaktionen
Published: March 2024

Forfatterliste
Energy Communities in EU Energy Regulation
Authors:   University of Upper Silesia Wojciech Korfanty in Katowice, Kmieć Jakub Mikołaj
Published: March 2024

EU Directives included in the ‘Clean Energy for All Europeans’ package introduced Renewable Energy Communities ECs (RECs) and Citizen ECs (CECs) into the legal framework, sharing commonalities, but with distinctions. The aim of this paper is to examine whether EU law provides for a single model of ECs or, in fact, two distinct models, and to characterize ECs as new participants in the energy market. The publication focuses on the field of legal studies and includes a literature review, an interpretation of EU provisions defining ECs, a characterization of ECs as new market participants, and a case study. The paper concludes that EU law indeed encompasses two models of ECs – RECs and CECs. The characterization of ECs as participants in the energy market is complex, and the case study illustrates that significant differences can exist among different examples of ECs, influencing their legal characteristics.
Energy Security of Ukraine: External Threats From the Russian Federation
Authors:   Vasyl’ Stus Donetsk National University, Lymar Valeriia
Published: March 2024

A country’s energy security is an important component of its overall national security, as energy supply is essential for the functioning of its national economy and the livelihoods of its population. The purpose of this research is to develop practical tools for analyzing the condition of Ukraine’s energy sector, and to provide practical recommendations for potential development and integration into the single European energy system. The practical value of the research findings is that the SWOT-analysis (Strengths – Weakness – Opportunities – Troubles) of the energy sector of Ukraine which makes it possible to identify the most acute problems and threats that have a negative impact on the energy sector of Ukraine and its integration into the European common energy system. Based on the results of the conducted SWOT-analysis, three potential scenarios for the development of Ukraine’s energy sector are proposed: a “no change” scenario (preservation of current trends and state of affairs); an “unfriendly influence” scenario (no systemic changes in energy policy combined with the escalation of aggression by the Russian Federation); and a “positive transformation” scenario (targeted efforts aimed at achieving the goals set out in this Strategy). The paper suggests the following possible ways of ensuring energy import substitution for Ukraine: development of renewable energy; development of energy efficiency; development of its own oil and gas industry; development of alternative energy sources; diversification of energy import sources; development of energy infrastructure; developing energy self-sufficiency in its individual regions.
EU Energy Solidarity as a Way of Implementing Just Transition in Energy Policy
Authors:   Warsaw University of Technology, Zajdler Robert
Published: March 2024

The principle of EU energy solidarity, regulated by Article 194 of the Lisbon Treaty, has created a new dimension of energy sector developments. Initially, it was treated as an abstract, purely political concept with no particular normative significance. However, the CJEU judgment in the OPAL case established energy solidarity as a principle of EU law, deriving, inter alia, from the principle of justice. The concept of just transition, based on the same foundations of justice, creates directions for socio-economic transformation based on a sustainable and low-carbon economy. Energy solidarity is, in fact, a way of implementing the assumptions and directions of the development of just transition, based on normative premises ensuring energy security, economic competitiveness and sustainable development.
The Road to Energy Justice as a Result of Interdisciplinary Cooperation in the Energy Policy Field
Authors:   John Paul II Catholic University of Lublin, Domagała Michał , Maćkowska Katarzyna ,   John Paul II Catholic University of Lublin
Published: March 2024

This article pertains to the role of law in regulating the energy market. Justice and solidarity in this area require a debate that should not be fragmented but must, instead, take place in an interdisciplinary manner. The key question that arises relates to the role that the law should play in the area of energy transformation, and thus, whether it should only be a tool for the implementation of political plans and action strategies, or whether it should, in itself, stimulate or determine the transition framework, or be a regulator of transformation. The article tackles selected problems related to Demand Side Management (DSM), de-growth, energy poverty, Not In My Back Yard (NIMBY) initiatives and Contracts for Differences (CfD), in order to call for interdisciplinary research and cooperation in this context.
The Behaviour of Dominant Firms and the Principle of Equal Opportunities: Lessons From the SEN Antitrust Saga Case Comment to the Servizio Elettrico Nazionale Judgment of the Court of Justice of 12 May 2022, Case C-377/20
Authors:   Faculty of Management, University of Warsaw, Zoboli Laura
Published: March 2024

This commentary concerns the Servizio Elettrico Nazionale (SEN) case that stems from the conduct of an incumbent operator – Enel S.p.A. – called upon to confront the liberalization process of the Italian electricity market. In particular, the former legal monopolist allegedly worked to consolidate its dominant position in the electricity production market, by denying its rivals access to a resource that would have been non-replicable and of strategic importance to compete in the liberalized electricity distribution market. This ruling is of fundamental importance as the Court of Justice discusses therein the objectives of antitrust law and the notion of exclusionary abuse. Moreover, in light of the practical interpretation of the ruling, it is important to ask whether the CJEU would have developed the same reasoning if the relevant market had not concerned an industry undergoing liberalization, such as the electricity sector. The commentary closes by referencing the more recent Unilever case, where the Court of Justice seems to confirm the opportunity of applying the “as efficient competitor test” to non-price practices even, in the absence of a market liberalization process.
Electrothermal Simulation of the Production of Alumina by Spark Plasma Sintering
Authors: Gök Mustafa Güven
Published: March 2024

Although the spark plasma sintering (SPS) method is a very advantageous technque in many aspects, the inability to clearly read the temperature formed on the material during sintering and heterogeneous temperature distributions are the biggest problems of this process. Therefore, it is a common situation that samples taken from different regions of the produced material have different densities and mechanical properties. In this study, the temperature distributions, current density and joule heating effect of the entire setup consisting of the alumina (Al2O3) sample to be sintered, inconel electrodes, graphite dies, punches and spacers, as well as the critical regions in this setup, are modeled by using finite element software. According to the results, the temperature is maximum at the centre of the Al2O3 sample and the temperature gradient along its radius is 22.4°C. The temperature difference between the inner wall of the hole which is opened in the graphite mold to measure the sintering temperature and the centre of the Al2O3 sample is around 40°C. In addition, during the SPS process, Al2O3 is not heated directly by the joule effect and the temperature gradient in the sample occurs due to mold surface radiation.
Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor
Authors: Jablonowski Carolyn M , Quarni Waise , Singh Shivendra , Tan Haiyan , Bostanthirige Dhanushka Hewa , Jin Hongjian , Fang Jie , Chang Ti-Cheng , Finkelstein David , Cho Ji-Hoon , Hu Dongli , Pagala Vishwajeeth , Sakurada Sadie Miki , Pruett-Miller Shondra M , Wang Ruoning , Murphy Andrew , Freeman Kevin , Peng Junmin , Davidoff Andrew M , Wu Gang , Yang Jun
Published: March 2024

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress and therapies is poorly understood. Here, we demonstrate that jumonji domain containing 6, arginine demethylase, and lysine hydroxylase, JMJD6, acts as a hub connecting splicing and metabolism in MYC-driven human neuroblastoma. JMJD6 cooperates with MYC in cellular transformation of murine neural crest cells by physically interacting with RNA binding proteins involved in pre-mRNA splicing and protein homeostasis. Notably, JMJD6 controls the alternative splicing of two isoforms of glutaminase (GLS), namely kidney-type glutaminase (KGA) and glutaminase C (GAC), which are rate-limiting enzymes of glutaminolysis in the central carbon metabolism in neuroblastoma. Further, we show that JMJD6 is correlated with the anti-cancer activity of indisulam, a ‘molecular glue’ that degrades splicing factor RBM39, which complexes with JMJD6. The indisulam-mediated cancer cell killing is at least partly dependent on the glutamine-related metabolic pathway mediated by JMJD6. Our findings reveal a cancer-promoting metabolic program is associated with alternative pre-mRNA splicing through JMJD6, providing a rationale to target JMJD6 as a therapeutic avenue for treating MYC-driven cancers.
Sensitive remote homology search by local alignment of small positional embeddings from protein language models
Authors: Johnson Sean R , Peshwa Meghana , Sun Zhiyi
Published: March 2024

Accurately detecting distant evolutionary relationships between proteins remains an ongoing challenge in bioinformatics. Search methods based on primary sequence struggle to accurately detect homology between sequences with less than 20% amino acid identity. Profile- and structure-based strategies extend sensitive search capabilities into this twilight zone of sequence similarity but require slow pre-processing steps. Recently, whole-protein and positional embeddings from deep neural networks have shown promise for providing sensitive sequence comparison and annotation at long evolutionary distances. Embeddings are generally faster to compute than profiles and predicted structures but still suffer several drawbacks related to the ability of whole-protein embeddings to discriminate domain-level homology, and the database size and search speed of methods using positional embeddings. In this work, we show that low-dimensionality positional embeddings can be used directly in speed-optimized local search algorithms. As a proof of concept, we use the ESM2 3B model to convert primary sequences directly into the 3D interaction (3Di) alphabet or amino acid profiles and use these embeddings as input to the highly optimized Foldseek, HMMER3, and HH-suite search algorithms. Our results suggest that positional embeddings as small as a single byte can provide sufficient information for dramatically improved sensitivity over amino acid sequence searches without sacrificing search speed.
Blockchain based general data protection regulation compliant data breach detection system
Authors: Ansar Kainat , Ahmed Mansoor , Malik Saif Ur Rehman , Helfert Markus , Kim Jungsuk
Published: March 2024

Context

Data breaches caused by insiders are on the rise, both in terms of frequency and financial impact on organizations. Insider threat originates from within the targeted organization and users with authorized access to an organization’s network, applications, or databases commit insider attacks.

Motivation

Insider attacks are difficult to detect because an attacker with administrator capabilities can change logs and login records to destroy the evidence of the attack. Moreover, when such a harmful insider attack goes undetected for months, it can do a lot of damage. Such data breaches may significantly impact the affected data owner’s life. Developing a system for rapidly detecting data breaches is still critical and challenging. General Data Protection Regulation (GDPR) has defined the procedures and policies to mitigate the problems of data protection. Therefore, under the GDPR implementation, the data controller must notify the data protection authority when a data breach has occurred.

Problem Statement

Existing data breach detection mechanisms rely on a reliable third party. Because of the presence of a third party, such systems are not trustworthy, transparent, secure, immutable, and GDPR-compliant.

Contributions

To overcome these issues, this study proposed a GDPR-compliant data breach detection system by leveraging the benefits of blockchain technology. Smart contracts are written in Solidity and deployed on a local Ethereum test network to implement the solution. The proposed system can generate alert notifications against every data breach.

Results

We tested and deployed our proposed system, and the findings indicate that it can accomplish the insider threat mitigation objective. Furthermore, the GDPR compliance analysis of our system was also evaluated to make sure that it complies with the GDPR principles (such as right to be forgotten, access control, conditions for consent, and breach notifications). The conducted analysis has confirmed that the proposed system offers capabilities to comply with the GDPR from an application standpoint.
Conspecific and heterospecific cueing in shelter choices of Blaptica dubia cockroaches
Authors: Freeberg Todd M. , Risner S. Ryan , Lang Sarah Y. , Fiset Sylvain
Published: March 2024

Background

Like many cockroaches, Argentinian wood roaches, Blaptica dubia, prefer darker shelters over lighter shelters. In three experiments, we asked whether chemical cues from other roaches might influence shelter choice, a process known as conspecific or heterospecific cueing, depending on whether the cues come from an individual of the same or a different species, respectively.

Methods

Each experiment involved trials with focal B. dubia cockroaches in testing arenas containing plastic shelters of varying levels of darkness, with filter paper under each shelter acting as a carrier for chemical cues. In Experiment 1, we tested female and male B. dubia cockroaches with two shelters matched for darkness but differing in cues (conspecific vs. none). The shelter with no cue contained a blank filter paper as a control. In Experiment 2 (conspecific cueing) and Experiment 3 (heterospecific cueing), we tested B. dubia cockroach choices for lighter or darker shelters with filter papers containing chemical cues of other roaches or no chemical cues. For the conspecific cueing study of Experiment 2, we used chemical cues from other B. dubia cockroaches. In contrast, for the heterospecific cueing study of Experiment 3, we used chemical cues from a different species, the death’s head cockroach, Blaberus craniifer.

Results

In Experiment 1, B. dubia cockroaches overwhelmingly preferred shelters with conspecific chemical cues over darkness-matched shelters without cues. In Experiments 2 and 3, they strongly preferred darker shelters, especially when chemical cues were present. Additionally, they were more likely to be under the lighter shelter when chemical cues were present there. These results reveal that the public information B. dubia cockroaches gain from chemical cues—including those from other species—can drive shelter choices in this species.
Comparing the effects of empagliflozin and liraglutide on lipid metabolism and intestinal microflora in diabetic mice
Authors: Yang Qiong , Deng Ling , Feng Changmei , Wen Jianghua
Published: March 2024

Background and Objectives

Recent studies have shown that the imbalance of intestinal flora is related to the occurrence and progression of diabetic nephropathy (DN) and can affect lipid metabolism. Sodium-dependent glucose transporters 2 (SGLT2) inhibitor and glucagon-like peptide-1 (GLP-1) receptor agonist are commonly used hypoglycemic drugs and have excellent renal safety. The purpose of this study was to compare the protective effects of empagliflozin and liraglutide on kidneys, lipid metabolism, and intestinal microbiota in diabetic mice.

Methods

We established a mouse model of type two diabetes by feeding rats a high-fat diet (HFD) followed by an intraperitoneal injection of STZ. The mice were randomly divided into groups: normal control (NC), diabetic model (DM), liraglutide treatment (LirT), empagliflozin treatment (EmpT), and liraglutide combined with empagliflozin treatment (Emp&LirT) groups. Blood glucose, lipids, creatinine, and uric acid, as well as urinary nitrogen and albumin levels were measured. The renal tissues were subjected to HE, PAS and Masson’s staining. These parameters were used to evaluate renal function and histopathological changes in mice. Mice feces were also collected for 16sRNA sequencing to analyze the composition of the intestinal flora.

Results

All the indexes related to renal function were significantly improved after treatment with drugs. With respect to lipid metabolism, both drugs significantly decreased the serum triglyceride levels in diabetic mice, but the effect of liraglutide on reducing serum cholesterol was better than that of empagliflozin. However, empagliflozin had a better effect on the reduction of low-density lipoproteins (LDL). The two drugs had different effects on intestinal flora. At the phylum level, empagliflozin significantly reduced the ratio of Firmicutes to Bacteroidota, but no effect was seen with liraglutide. At the genus level, both of them decreased the number of Helicobacter and increased the number of Lactobacillus. Empagliflozin also significantly increased the abundance of Muribaculaceae, Muribaculum, Olsenella, and Odoribacter, while liraglutide significantly increased that of Ruminococcus.

Conclusion

Liraglutide and empagliflozin were both able to improve diabetes-related renal injury. However, the ability of empagliflozin to reduce LDL was better compared to liraglutide. In addition, their effects on the intestine bacterial flora were significantly different.