bluuebunny/crossref_metadata_2025 huggingface dataset:
Corilagin Alleviates Ang II-Induced Cardiac Fibrosis by Regulating the PTEN/AKT/mTOR Pathway
Authors: Zhang Xiaogang , Tian Bei , Cong Xinpeng , Ning Zhongping
Published: September 2024

This research aimed to evaluate the therapeutic effect of corilagin (Cor) against angiotensin II (Ang II)-induced cardiac fibrosis and its underlying mechanisms. C57BL/6 mice (male, 8-10 weeks) received saline or Ang II (2.0 mg/kg/day) via subcutaneous infusion and intraperitoneal injection of Cor (30 mg/kg) for 28 days. Ang II induction increased the fibrotic area, whereas Cor treatment inhibited the fibrotic area significantly. Cor markedly reduced the Ang II-induced cardiac fibroblasts. Cor significantly inhibited Ang II-induced increase in expressions of smooth muscle alpha-actin (α-SMA), collagen I, collagen III, transforming growth factor beta 1 (TGF-β1), fibronectin, and connective tissue growth factor (CTGF). Cor suppressed the intracellular reactive oxygen species (ROS) production. Cor therapy reduced Ang II-induced malondialdehyde (MDA) content, whereas superoxide dismutase (SOD) and catalase (CAT) activities were increased (all, P < .001). Moreover, Ang II induction elevated the expression of phosphorylated phosphatase and tensin homolog (p-PTEN), phosphorylated protein kinase B (p-AKT) (Ser473) and phosphorylated mammalian target of rapamycin (p-mTOR) (Ser 2448), whereas Cor reduced their expressions. Cor treatment inhibited the migration ability of the cardiac fibroblast, whereas a PTEN inhibitor, VO-ohpic, increased the migration capability. Cor could have a protective effect against Ang II-induced cardiac fibrosis via inhibition of the PTEN/AKT/mTOR pathway.
Quality Criteria: General and Specific Guidelines for Qualitative Approaches in Psychology Research. A Concise Guide for Novice Researchers and Reviewers
Authors: Cena Elida , Brooks Joanna , Day William , Goodman Simon , Rousaki Anastasia , Ruby-Granger Victoria , Seymour-Smith Sarah
Published: September 2024

The purpose of this paper is to offer a comprehensive guide for novice researchers (mostly applicable to PhD students and those new to qualitative research), teachers, and reviewers of qualitative psychology research methods. This paper delineates the main quality criteria across qualitative methods: providing a holistic framework that covers fundamental principles as well as nuanced, context-specific guidelines relevant to a chosen qualitative approach. First, we demonstrate why this overview is needed, in part because of an increasing emphasis on finding sound ways of appraising qualitative studies, the lack of agreement on quality markers, and the variety of qualitative research methodologies available. Next, we present general criteria for quality across all qualitative methods, before setting out method specific criteria for four commonly used qualitative research approaches: Reflexive Thematic Analysis (RTA), Interpretative Phenomenological Analysis (IPA), Critical Discursive Psychology/Discursive Psychology (CDP/DP) and Constructivist Grounded Theory (CGT). While the focus is on providing criteria specific to these methodological approaches, we also describe the broader philosophical foundations underpinning these approaches and other branches within these philosophies, recognising that methodological criteria can be contrasting and competing even within methodologies. The integration of general and approach-specific criteria cultivates a deeper understanding of both the philosophical underpinnings and practical intricacies of qualitative inquiry, empowering researchers to navigate the methodological landscape with critical acumen and intellectual humility. Finally, we compare the four methodologies in terms of key features and qualities they aim to achieve. The paper emphasizes that even though there are criteria that are common across the field, it is essential to maintain the specific stance of each individual methodological approach.
Anatomical variations of origin of the internal carotid artery: Report of two cases and systematic review of the literature
Authors: Ramputi Lucia , Mazzaccaro Daniela , Tissir Karima , Trevisan Manuel Bruno , Conte Gianluca , Nano Giovanni , Menicanti Lorenzo , Castelvecchio Serenella
Published: September 2024

Background

Anatomical variations of origin of the internal carotid artery (ICA) are very uncommon and may pose a diagnostic and therapeutic challenge.

Objective

We report a case of direct origin of the right ICA from the innominate artery (aplasia of common carotid artery) and a case of duplication of right ICA in healthy patients who performed duplex ultrasound (DUS) for primary cardiovascular prevention screening.

Methods

In both cases, the ultrasound scan was performed both in a transverse plane and on the longitudinal axis, and in one of the two cases, a computed tomography angiography was performed to confirm the diagnosis. A review of the current literature about anatomical variations of origin of carotid arteries was also performed.

Results

The most frequent congenital anomaly is represented by the aplasia of the CCA, followed by the agenesis and by the duplication of the ICA. In most cases, the anomaly is discovered occasionally and symptoms are aspecific. Diagnosis is usually confirmed through a multimodality imaging approach, including DUS of extracranial carotid arteries, magnetic resonance imaging (MRI), and computed tomographic angiography. In most cases, treatment was conservative, with pharmacological therapy aimed at the symptoms.

Conclusion

The recognition of such variations is mandatory, particularly when the patient needs a surgical treatment that may involve the vessel with the anatomical variations.
Environmentally sustainable opportunities for health systems: Metered-dose inhaler prescribing, dispensing, use and waste at a tertiary academic centre
Authors: Caron Carolanne , Sajwani Shellyza , Bateman Katherine , Degenhardt Owen , Gaudreau-Simard Mathilde , Pakhale Smita , Kanji Salmaan
Published: September 2024

Background:

The Canadian health sector’s carbon footprint is among the highest in the world and is responsible for 4.6% of Canada’s total greenhouse gas emissions, a quarter of which is linked to pharmaceuticals, with metered-dose inhalers (MDIs) contributing disproportionally high amounts.

Objectives:

To describe MDI prescribing, dispensing, use and waste patterns at a Canadian tertiary care academic hospital.

Methods:

In a retrospective point-prevalence cohort study, 100 consecutive patients discharged from medical and surgical services who were prescribed at least 1 MDI during their admission were included. Data were collected to describe patient demographics, MDI prescribing, dispensing, use and waste patterns. Use and waste data were applied to annual purchasing data to estimate annual usage and waste. Financial cost was computed using local purchasing estimates and carbon cost was calculated using published estimates.

Results:

In 100 consecutively discharged patients, 315 MDIs were dispensed in total, of which 96 were unused. This represents 61,440 actuations dispensed, with 56,773 (92%) of doses unused or wasted. Waste data were applied to annual estimates, with a calculated annual carbon footprint of 315.8 tons of carbon dioxide equivalent (tCO2e). We estimate that a 20% waste reduction would result in carbon savings of 68.5 tCO2e. If 20% of salbutamol prescriptions were switched to the dry powder inhaler alternative, terbutaline, a 14% reduction in waste would be required to offset the additional monetary cost.

Conclusions:

This study suggests that 92% of MDI doses are unused and wasted. Opportunities for waste reduction exist and would be associated with both financial and carbon savings.
Two-Spirit Peoples’ experiences accessing and receiving care from community pharmacies
Authors: Pirlot Marissa , Swidrovich Jaris
Published: September 2024

Background:

Two-Spirit Peoples face unique challenges in accessing and receiving health care in Canada due to health services, including community pharmacy services, being built on hetero- and cis-normative models that impede appropriate care for this group. Currently, there is limited published information on Two-Spirit Peoples’ experiences accessing and receiving care in community pharmacy settings.

Methods:

To address the lack of published information, 21 Two-Spirit individuals shared their experiences in a focus group setting. Four different focus groups were held across Canada, including 1 in Saskatoon, Vancouver, Edmonton, and Toronto. Informed by Indigenous methodologies, data were recorded via audio recording and notetaking, and the audio was transcribed and then analyzed for themes using the Voice-Centred Relational Method.

Results:

Three major structural systems that affect the experiences of Two-Spirit Peoples in community pharmacies were identified: 1) white supremacy, 2) capitalism, and 3) heteronormativity. These 3 systemic issues presented themselves via racism, homophobia, transphobia, pharmacists’ lack of knowledge about Two-Spirit individuals and their health and lack of time spent educating or building relationships with Two-Spirit Peoples. Participants provided suggestions for how community pharmacists can better serve the Two-Spirit community, such as using inclusive language, adding pronouns and preferred names to patient files, increasing knowledge about Two-Spirit health and advocating for Two-Spirit Peoples.

Discussion:

The results suggest that dismantling current structures and ideologies in community pharmacy and society are required to overcome the identified issues.

Conclusion:

Two-Spirit Peoples face barriers when it comes to accessing and receiving care in community pharmacies, resulting in many Two-Spirit individuals avoiding health care to save themselves from unsafe and uncomfortable interactions. Pre- and postlicensure pharmacy education about Two-Spirit Peoples is required to improve Two-Spirit Peoples’ experiences accessing and receiving care in community pharmacies.
MFFNet: Multimodal feature fusion network for RGB-D transparent object detection
Authors: Zhu Li , Li Tuanjie , Ning Yuming , Zhang Yan
Published: September 2024

Transparent objects are ubiquitous in everyday life, but how to detect them is full of challenges. Transparent objects hardly reflect light, and they usually transmit the appearance of their surroundings, making it difficult to distinguish them from their surroundings. Existing methods usually use only RGB (Red Green Blue) images as input, ignoring the role of depth maps in transparent object detection. In this article, we try to improve the detection performance of transparent objects by fusing RGB and depth information. Specifically, we propose a multimodal fusion network that fuses RGB and depth modalities in a complementary way. Moreover, extensive experiments and ablation studies on the RGB-D (RGB-Depth) transparent object dataset demonstrate the excellent performance of our method.
Access to (E)-N′-benzylidene-N-(2-(phenylsulfonyl)ethyl)acetohydrazide via C(sp2)−H activation and reduction of (E)-N′-benzylideneacetohydrazide with (vinylsulfonyl)benzene
Authors: Wang Haiyang , Liu Fusheng
Published: September 2024

A novel route for C(sp3)-N bond formation via C(sp2)−H activation/reduction by metal-free which uses ( E)- N′-benzylideneacetohydrazide and (vinylsulfonyl)benzene to synthesize derivatives of ( E)- N′-benzylidene- N-(2-(phenylsulfonyl)ethyl)acetohydrazide has been reported. This methodology features good functional group tolerance and convenient operation. In addition, it uses inexpensive and insensitive chemical reagents as raw materials and provides an atom- and efficient method for the preparation of ( E)- N′-benzylidene- N-(2-(phenylsulfonyl)ethyl)acetohydrazides.
Within power constraints: Forty years of the successes and failures of talent shows in China
Authors: Qing Shenglan , Prado Emili
Published: September 2024

This study reveals the transformation of representation and voting mechanisms in the successes and failures of talents shows in China over the past four decades. This article analyses how talent shows have been shaped within the constraints of political power in China, global neoliberal economic logic and the collective power of population. As an inherent tactic of talent shows to engage the populations of audiences, users and consumers in commercial society, voting mechanisms have not been suspended but rather modified. Talent shows ranged across a spectrum of bureaucratic/commercial elitism and ordinariness. In this context, the power of Capital is considered as furthering unfairness in public discourse.
Ultrasound-guided bilateral anterior quadratus lumborum block at the lateral supra-arcuate ligament in patients undergoing laparoscopic radical gastrectomy: A randomised controlled study
Authors: Lin Liangqing , Yu Yaohua , Ke Pinhui , Liu Lili , Wu Qinghua , Lin Qingshui
Published: September 2024

Objective:

Ultrasound-guided bilateral anterior quadratus lumborum block at the lateral supra-arcuate ligament has recently been proposed as an effective analgesia for abdominal surgery. To test the hypothesis that this novel technique was a viable alternative approach of conventional thoracic epidural analgesia for laparoscopic radical gastrectomy.

Methods:

Three hundred patients scheduled for laparoscopic radical gastrectomy were randomised 1:1 into the anterior quadratus lumborum block group: receiving the novel regional analgesia, and the thoracic epidural analgesia group: receiving thoracic epidural anaesthesia. The primary endpoint was intraoperative consumption of propofol and remifentanil. Intention-to-treat analysis was performed for all variables.

Results:

At five and ten minutes after block, anterior quadratus lumborum block group achieved more dermatomes coverage of the sensory block with both p < 0.001. Intraoperative consumption of propofol and remifentanil was comparable between two groups (1116.21 ± 199.76 versus 1166.45 ± 125.31µg, p = 0.245 and remifentanil 1.83 ± 0.41 versus 1.81 ± 0.37ng, p = 0.988). However, anterior quadratus lumborum block group was associated with less intraoperative consumption of norepinephrine and atropine, shorter time to urinary catheter removal and out-of-bed activity than the thoracic epidural anaesthesia group. No significant difference in extubation time, pain scores at rest and exercising at all time points following surgery was observed between the two groups.

Conclusions:

Compared with conventional thoracic epidural anaesthesia, the novel technique was an equivalent effective component of multimodal analgesic protocol for laparoscopic radical gastrectomy. There were some advantages, including shorter procedure time, more reliable dermatomal coverage, shorter duration of urinary catheterisation and earlier time of out-of-bed activity to enhance recovery after surgery.

Trial registration:

The study was registered in the Chinese Clinical Trial Registry on 2 November 2022 (ChiCTR2200065325).
Safety and efficacy of the Tao facemask for positive pressure ventilation in morbidly obese patients
Authors: Brewbaker Carey L , Wilson Phillip R , McSwain Julie R , Tobin Catherine D , Bridges Kathryn H , Roberts Laura L , Wilson Dulaney A , Skorke Christopher A , Brown Tod A
Published: September 2024

Purpose:

Positive-pressure mask ventilation is an essential skill for individuals providing basic and advanced airway interventions in a variety of clinical settings. The C-E grip technique is most commonly used with standard facemasks to provide an effective seal that allows for positive pressure ventilation. The Tao mask is a novel facemask that utilises an ergonomic grip by using downwards pressure of the palm of the hand accompanied by midline jaw lift. Specifically, the technique to create a seal involves downwards pressure of the palm centred on the mask accompanied by a jaw lift with four fingers centred under the mandible. A previous comparison between the Tao and standard masks revealed superior performance across a cross-section of average patients. The purpose of this study was to evaluate the safety and effectiveness of the Tao mask compared to the standard mask in a subset of patients with morbid obesity as defined by a body mass index (BMI) greater than or equal to 40 kg/m2.

Methods:

This prospective crossover trial included 156 patients aged ⩾18 years at the Medical University of South Carolina who were scheduled for elective surgery under general endotracheal anaesthesia with a BMI of ⩾40 kg/m2 at the time of surgery. After the induction of general anaesthesia, but prior to the administration of a neuromuscular blocking drug (NMBD), each patient was ventilated with both the standard and Tao masks, and effectiveness was measured using both the Han and Warters scales. The process was repeated after the administration of an NMBD.

Results:

Data were collected and analysed from 153 individuals. The mean BMI was 50.7 ± 9.3 kg/m2. The Tao mask ventilation scores were significantly lower (more effective) than the standard mask scores on both the Han and Warters Scales before pre-NMBD ( p = 0.0002 and p < 0.001, respectively) and after post-NMBD ( p = 0.002 and p < 0.001, respectively). On the Warters Scale, it was significantly easier to ventilate with the Tao Mask pre-NMBD ( p = 0.0001). On the Han Scale, the Tao mask was significantly easier than the standard mask post-NMBD ( p = 0.03). With regard to mask sequence, the mean Warters scores were lower for the Tao mask pre-NMBD only when the standard mask was used first ( p = 0.002). Similarly, the difference in the mean Warters scores post-NBMD was significant only when the standard mask was used first ( p = 0.02).

Conclusion:

The Tao mask demonstrated equivalent safety and superior effectiveness in ventilating morbidly obese surgical patients despite a trial design that favoured the standard mask owing to anaesthetist experience. The use of the Tao mask may be particularly beneficial in clinical situations involving inexperienced operators or in patients for whom mask ventilation is likely to be difficult.

ClinicalTrials.gov registration number:

NCT03473366
Naturalization of work accidents through political dynamics: A discursive analysis
Authors: Çil Umut , Özcan Kerim
Published: September 2024

Over the last two decades a number of devastating work accidents have occurred in Turkey that have resulted in massacre-like deaths and destructions. Although dramatic consequences forced all actors to promise for betterment, no significant improvement has been achieved yet and one accident followed the other. Apart from social and economic factors, political power tends to be attributed to having the most critical responsibility in all incidents. The present government, which has been in power since 2002, has aimed and achieved to create a pro-government capitalist class who can dominate specific sectors, such as construction, energy and mining in which most of the serious accidents occur. By taking the control of media, the government not only attained the majority of communicative channels but also created a manipulative discourse potential that has enabled to shade reality concerning the accidents. In this regard, the purpose of this study is to analyze how these accidents are normalized by the government’s discourses. A multi-stage naturalization model is employed to reveal the production and circulation of discourses in public sphere during the framing process of the accidents. The model can also be used to propose a solution for de-naturalization, which is also one of the aims of this study.
Unlocking the potential of deferoxamine: a systematic review on its efficacy and safety in alleviating myocardial ischemia-reperfusion injury in adult patients following cardiopulmonary bypass compared to standard care
Authors: Lamichhane Aashish , Sharma Sadish , Bastola Bishwas , Chhusyabaga Bikesh , Shrestha Nabin , Poudel Prajwal
Published: September 2024

Background:

Reperfusion injury, characterized by oxidative stress and inflammation, poses a significant challenge in cardiac surgery with cardiopulmonary bypass (CPB). Deferoxamine, an iron-chelating compound, has shown promise in mitigating reperfusion injury by inhibiting iron-dependent lipid peroxidation and reactive oxygen species (ROS) production.

Objectives:

The objective of our study was to analyze and evaluate both the efficacy and safety of a new and promising intervention, that is, deferoxamine for ischemia-reperfusion injury (I/R).

Design:

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines are used to perform the study.

Data sources and methods:

We conducted a systematic review following PRISMA guidelines to assess the efficacy and safety of deferoxamine in reducing I/R injury following CPB. A comprehensive search of electronic databases, namely, PubMed, Scopus, and Embase, yielded relevant studies published until August 18, 2023. Included studies evaluated ROS production, lipid peroxidation, cardiac performance, and morbidity outcomes.

Results:

(a) ROS production: Multiple studies demonstrated a statistically significant decrease in ROS production in patients treated with deferoxamine, highlighting its potential to reduce oxidative stress. (b) Lipid peroxidation: Deferoxamine was associated with decreased lipid peroxidation levels, indicating its ability to protect cardiac tissue from oxidative damage during CPB. (c) Cardiac performance: Some studies reported improvements in left ventricular ejection fraction and wall motion score index with deferoxamine.

Conclusion:

Our review shows that deferoxamine is an efficacious and safe drug that can be used to prevent myocardial I/R injury following CPB. It also highlights the need for trials on a larger scale to develop potential strategies and guidelines on the use of deferoxamine for I/R injury.
A single trunk-mounted wearable sensor to measure motor performance in triathletes during competition
Authors: Chesher Stuart M , Rosalie Simon M , Chapman Dale W , Charlton Paula C , van Rens Fleur ECA , Netto Kevin J
Published: September 2024

The objective of this research was to validate a single, trunk-mounted wearable sensor (Optimeye S5, Catapult Australia, Melbourne) to measure the cadence of swimming strokes, cycling pedals and running strides in a triathlon. While similar validations have been performed in swimming and running, it is a novel application in cycling, and thus, across a whole triathlon. Seven triathletes were recruited to participate in a sprint distance triathlon which was filmed and simultaneously measured by a single, trunk-mounted wearable sensor. To validate the wearable sensor, individual swimming strokes, cycling pedal strokes and running strides were manually counted by viewing the wearable sensor data and video footage. While analysing cycling data, changes in cycling subtask performances were noticed, thus, a secondary analysis in cycling was conducted to investigate. The 95% limits of agreement analysis indicated the sensor validly measured swimming strokes (mean bias = −0.034 strokes), cycling pedal strokes (mean bias = −0.09 strokes) and running strides (mean bias = 0.00 strides) with minimal to no bias ( p > 0.05). Further analysis of cycling revealed the wearable sensor is an acceptably valid tool to measure the duration of out of saddle riding (mean bias = 0.08 s), however, significant differences in the duration of in saddle riding (mean bias = −0.5 s) and coasting were identified (mean bias = 0.39 s). A single trunk mounted wearable sensor is a valid tool to measure movement cadence in a triathlon, however, further validation is required to generate a full understanding of cycling subtask performances.
Effects of training repetition on young footballers’ tactical and physical performances: free and conditioned large-sided games
Authors: Gonzalez-Artetxe Asier , Folgado Hugo , Los Arcos Asier
Published: September 2024

This study evaluated the consequences of repeating the same large-sided games, playing free or conditioned, during several training sessions on young footballers’ tactical and conditional performances and their variabilities. Thirty-two U14 and U16 developmental male footballers participated in the study. Both teams, divided into two balanced groups (free play and conditioned), faced each other during three eight-a-side games (seven vs seven, plus goalkeepers) during three training sessions. The free-play groups played as they pleased, while the conditioned groups played the games conditioned by tactical instructions. Tactical performance was assessed by central tendency and normalized approximate entropy measures of the distance of each player to the team centroid (m) and the distance of each player to their mean position (m), while the conditional performance was assessed by total distance (m) and walking, jogging, running, and sprinting distances traveled (m), and number of accelerations and decelerations performed. Whereas players’ average tactical and conditional responses scarcely varied between sessions, inter- and intra-player variabilities were always considerable (coefficient of variation >10%) regardless of the task conditions and the age group. In addition, all footballers’ conditional variability was substantially higher at faster speeds (jogging, running, and sprinting distances) than at slower ones (total distance and walking distance traveled), and for accelerations and decelerations performed. Implementing large-sided games with or without tactical instructions may be an appropriate training strategy to ensure stable and constant average responses for the team. Nevertheless, academy football coaches should bear in mind and manage the variability between and within players.
In vitro quantification of the resistance force properties of a hydraulic resistance device designed for sprinting
Authors: Sašek Matic , Cvjetičanin Oskar , Šarabon Nejc
Published: September 2024

The hydraulic resistance device (HRD), a state-of-the-art device developed primarily for resisted sprint training, lacks exploration of its force-generating properties. This technical note aims to evaluate these properties in vitro. In a laboratory experiment, the HRD was pulled with a motorised winch at four speeds (1–4 m s−1) and 12 different HRD resistance levels (low, medium and high). The resistance force induced by the HRD was measured using a force plate mounted under the device, and calculated as mean horizontal force produced at a constant pulling speed. Resistance force repeatability between pulling speeds at specific resistance levels was assessed using the coefficient of variation (CV) whereas the intraclass correlation coefficient (ICC3,1) was calculated to determine the consistency. A linear regression model quantified resistance force as a function of HRD resistance level. Accuracy of the model was assessed using root mean square error (RMSE). Across 12 resistance levels, the HRD produced resistance forces ranging from 22.57 ± 4.84 to 164.57 ± 4.84 N. The CV decreased from 21.5% at the lowest resistance to 0.4% at the highest. The HRD produced resistance force with high consistency (ICC3,1 CI = 0.990–0.999). The linear regression model showed a near-perfect fit ( R2 = 0.99) and predicted resistance force more accurately at medium and high resistance (RMSE range = 0.97–4.57 N). The HRD provides favourable force-generating properties for resisted sprint training and testing, warranting further studies on its exploration in vivo.
Classification of movements of collegiate female soccer players using inertial measurement units
Authors: Masui Yuki , Hirotsu Nobuyoshi , Shimasaki Yu , Yoshimura Masafumi
Published: September 2024

This study aimed to classify the movements of female soccer players during matches using raw data measured by inertial measurement units (IMUs). Twelve collegiate female soccer players were equipped with IMUs (100 Hz), and raw triaxial acceleration data from eight official matches were analyzed. The measurement data were separated every 3 s, and a Fast Fourier Transform (FFT) was performed. After FFT, the Euclidean distances between the data when the players were in the stationary state and other states were calculated to classify the movements of the players using the k-means method. The data of the clustering numbers classified as the stationary state were eliminated after analyzing the movements of players by video filming the matches. After classification, the average Euclidean distances between the stationary state and other movements were calculated. Consequently, the results showed that the upward and downward directions of the raw data affected the classification. Using the methods of this study, it was also shown that the distribution of Euclidean distances differed from player to player. Our findings indicate that the method used in this study can be used to classify and characterize the movements of female collegiate soccer players.
Predicting offensive sector entry during transition moments in soccer
Authors: Armatas Vasilis
Published: September 2024

Transitions, rapid attacks after regaining possession, are a potent weapon, yet their lower frequency compared to organized attacks highlights a need for understanding factors that influence their success, particularly regarding offensive sector entry. This study investigates factors influencing the success of transitions, with a specific focus on predicting their ability to penetrate the opponent’s offensive sector. We analyzed 1911 ball recoveries from the 2018 to 2019 Greek SuperLeague. Chi-squared tests and binary logistic regression were employed to examine the influence of recovery type, number of defenders, passing patterns (including penetrative passes), and other variables on successful transitions. Our findings reveal that the likelihood of entering the offensive sector significantly increased when the ball was recovered in advanced areas, against fewer defenders, involved a high proportion of penetrative passes, and had a longer offensive sequence duration. This model provides a framework for predicting offensive sector entry during transitions, offering valuable insights for coaches seeking to optimize training drills and maximize transitional effectiveness.
Preliminary results on temporal evolution and clinical implications of atherosclerotic plaque in branch atheromatous disease after statin treatment
Authors: Huang Yen-Chu , Tsai Yuan-Hsiung , Lin Leng-Chieh , Weng Hsu-Huei , Lee Jiann-Der , Yang Jen-Tsung
Published: September 2024

Background:

Branch atheromatous disease (BAD) is a primary cause of early neurological deterioration (END) in penetrating artery occlusion, leading to poor functional outcomes. While it has been proposed to classify BAD under large artery atherosclerosis, uncertainty exists regarding the optimal treatment strategy, including cholesterol-lowering targets.

Objectives:

We aimed to assess the clinical implications and temporal changes of atherosclerotic plaques before and after high-intensity statin treatment.

Design:

This is a high-resolution vessel-wall imaging sub-analysis of the trial of Statin and Dual Antiplatelet Therapy in Preventing Early Neurological Deterioration in Branch Atheromatous Disease (SATBRAD).

Methods:

In this prospective, single-group cohort study, participants in the treatment arm of the SATBRAD trial received early dual antiplatelet therapy and high-intensity statin treatment. The majority of these participants subsequently underwent high-resolution vessel-wall magnetic resonance imaging (MRI). Those with atheromatous plaques in the parent artery continued high-intensity statin treatment for 6 months, followed by a repeat MRI to monitor plaque changes.

Results:

There were 57 patients who underwent vessel-wall imaging and 24 exhibited contrast-enhanced plaques. Patients with contrast-enhanced plaques showed higher rates of END (29.2% vs 6.1%, p = 0.027), perfusion defects (62.5% vs 24.2%, p = 0.004), and lower rates of good outcomes at 3 months (50.0% vs 81.8%, p = 0.011). After adjusting for confounding factors, contrast-enhanced plaque had a negative impact on achieving a good outcome at 3 months (adjusted odds ratio = 0.04; 95% confidence interval = <0.01–0.60). Following high-intensity statin treatment in 36 patients, there was a notable reduction in stenosis (33.7% vs 29.3%, p = 0.005) and contrast-enhanced plaque volume (16.3 vs 11.6 mm3, p = 0.015).

Conclusion:

The study highlighted the association between contrast-enhanced atherosclerotic plaques, END, and poor functional outcomes, with high-intensity treatment leading to plaque volume reduction. These results underscore the shared pathology between BAD and intracranial atherosclerosis, emphasizing the necessity for further research and tailored treatment strategies for BAD.

Trial registration:

ClinicalTrials.gov; Identifier: NCT04824911 ( https://clinicaltrials.gov/study/NCT04824911 ).
Bone marrow edema in children: chronic nonbacterial osteomyelitis and its mimickers
Authors: Giraudo Chiara , Fichera Giulia , Michielin Anna , Zulian Francesco , Stramare Roberto , Rennie Winston J.
Published: September 2024

Bone marrow is a highly cellular tissue undergoing significant developmental and physiologic changes with age. Indeed, with maturation from pediatric to the adult age there is a progressive, centrifugal conversion from red to yellow bone marrow. Histological characteristics of bone marrow are reflected in MR image signal. MR is therefore extremely sensitive in detecting pathological changes which are mostly characterized by increased free water causing high signal intensity on T2. Among the numerous diseases causing bone marrow edema in children chronic nonbacterial osteomyelitis (CNO) certainly has to be mentioned. This idiopathic inflammatory disorder is characterized by nonspecific migrating symptoms like skeletal pain with phases of exacerbations and relapses with alternating acute and chronic MR signs and it is often a diagnosis of exclusion. Hence, with bone marrow edema, various features at imaging should be considered to differentiate malignancies such as osseous lymphoma, osteosarcoma, and Ewing’s sarcoma as well as benign lesions like osteomyelitis, post-traumatic, or post-treatment bone marrow edema. The aim of this review is to recall the main characteristics of CNO and provide an overview of its main mimickers highlighting similarities and differences.
Alangium Lam.: A Review of Its Botany, Phytochemistry, and Mechanism of Action Against Tumor
Authors: Li Rui , Deng Qian , Zhang Hao , Kong Yunzhen , Wang Huannan , Zhang Zhen , Sai Chunmei
Published: September 2024

Background: The Alangium Lam. belongs to the Alangiaceae family and contains over 30 species. Researchers have identified over 300 phytochemicals from these species, including alkaloids, glycosides, terpenes, lignans, flavonoids, and steroids. However, there is no review of the antitumor properties of the Alangium genus, and the subsequent information on the mechanism of its antitumor action is not comprehensive enough. Methods: This article reviews previous studies on the Alangium obtained from various sources, including the CNKI, PubMed, Google Scholar, Connected Paper, and the chemical abstracts service (CAS). Results: Among these compounds, 85 have been found to possess anti-tumor properties, mainly belongs to alkaloids, glycosides, and terpenes. This will provide new insights and a broader perspective for future research on the effects of anti-tumor chemicals and their mechanisms of action within this plant genus.
The Influence of Weather Conditions on the Immortelle Volatile Constituents from Essential oil and Hydrosol with a Focus on Italidiones and Its Molecular Docking Anti-Inflammatory Potential
Authors: Aćimović Milica , Stanković Jeremić Jovana , Todosijević Marina , Cvetković Mirjana , Lončar Biljana , Vukić Vladimir , Erceg Tamara , Pezo Lato , Zheljazkov Valtcho D.
Published: September 2024

Objectives

Immortelle has garnered global attention for its cosmetic, medicinal, and culinary applications worldwide. Apart from neryl acetate, α-pinene and γ-curcumene as the most important components for the estimation of the essential oil quality, in recent years a group of β-diketones, known as italidiones, appear as significant quality parameters. However, it is unknown how weather conditions (temperature and precipitation) influence their accumulation in essential oil and hydrosol, nor their anti-inflammatory potential.

Methods

This study investigates the chemical composition of immortelle essential oil and hydrosol over three successive years (2019/20, 2020/21, and 2021/22), by GC-FID and GC-MS analysis. In silico molecular docking model with Vascular Adhesion Protein-1 (VAP-1) was used for the simulation of the anti-inflammatory potential of italidiones, as well as other β-diketones present in immortelle essential oil and hydrosol.

Results

During the three-year trial, it was established that essential oil compounds such as α-pinene, neryl acetate, and italicene were positively correlated with temperature and negatively correlated with precipitation, as well as β-diketones and total italidiones. Moreover, trans-caryophyllene, γ-curcumene, and ar-curcumene were in negative correlation with temperature, and a slight positive correlation with precipitation. On the other side, in the hydrosol the content of both total β-diketones and total italidiones was strongly negatively correlated with temperatures, and positively correlated with precipitation, which was the opposite of essential oil. Additionally, findings indicated that italidiones could bind the human VAP-1 protein in the vicinity of the topiquinone and block its function.

Conclusion

Weather conditions affect variations in the accumulation of volatile compounds in essential oil and hydrosol, which in some cases can affect changes in olfactory characteristics, as well as criteria prescribed by standards, and even changes in biological activities. These results indicate that italidiones, as well as other β-diketones present in immortelle, may be responsible for its anti-inflammatory activity.
Pilates Dosage in Rehabilitation of Patients With Musculoskeletal Conditions: A Scoping Review
Authors: Sivrika Aikaterini Pantelis , Kypraios Georgios , Lamnisos Demetris , Georgoudis George , Stasinopoulos Dimitrios
Published: September 2024

Context:

Pilates exercise is commonly used in the rehabilitation of individuals with musculoskeletal conditions, but dosing parameters for optimal outcomes are unclear. Large variations exist in Pilates-based protocols, and research related to specific dosing is sparse.

Objective:

To identify optimal dose parameters of Pilates exercise when applied to the rehabilitation of musculoskeletal conditions.

Data Sources:

English-language articles published up to February 2023, in the PubMed, Scopus, Science Direct, and Pedro databases.

Study Selection:

Articles where patients 20–60 years old with musculoskeletal conditions received a Pilates-based exercise intervention and reported quantification of treatment dose. A total of 72 full-text articles were assessed, with 14 meeting inclusion criteria.

Study Design:

Scoping review.

Data Extraction:

Two investigators (A.P.S., G.K.) independently identified all proposed Pilates-based protocols and outcome measures from the included studies.

Results:

From the 1667 references initially found in 4 databases, 14 studies were included of which 13 were randomized controlled trials or quasi-experimental (612 patients) and 1 was a Cochrane review (19,642 patients). Eight studies were of high methodological quality. The most frequent musculoskeletal condition examined was chronic low back pain. Pilates dosage regarding total intervention duration ranged from 6 to 16 weeks, but the most frequent duration reported was 8 weeks and 2 to 3 sessions per week with sessions lasting 50 to 60 minutes.

Conclusion:

This review suggests that there are clinically relevant Pilates dosing parameters that result in improved outcomes for patients with musculoskeletal disorders.
Enhancing structural protection of reinforced concrete structures against high dynamic loads using post-installed UHPFRC/UHPFRSC
Authors: Strotmann Andre , Jungwirth Jörg , Zohrabyan Vahan , Braml Thomas
Published: September 2024

Recently there has been an observed change in security policy across the globe which implies that humanity must prepare for hybrid and asymmetric acts of war. This security situation will result in spontaneous attacks from non-military groups. The threats include ballistic attacks from commercially available weapons, detonation of explosives, and impact of vehicles. These attacks are focused on critical infrastructures. Reinforced concrete (RC) elements with ballistic and explosion protection are of huge relevance. This requires new concepts and innovative solutions for the protection of new buildings and/or for the strengthening of existing structures. In this paper a method for the increase of structural safety is shown using Ultra-High Performance Fiber Reinforced Concrete (UHPFRC) or sprayed UHPFRC, so called UHPFRSC, as a surface layer for reinforced concrete structures. The UHPFRC/UHPFRSC is applied in thin layers of 30 - 80 mm on the protection side. The interaction of the two different cementitious materials results in increased resistance to high dynamic loads. The traditional reinforced concrete on the impact side absorbs a major fraction of the energy of impact. On the back side (protection side), tensile forces are generated by the impact, which can excellently be handled by the UHPFRC/UHPFRSC. For proof of concept of the hybrid strengthening method, tests were carried out on UHPFRC - RC composite elements. In the test campaign, ballistic tests were performed using test specimens with dimensions of 500 × 500 mm. The layer thicknesses were 120 mm reinforced concrete and 40 mm UHPFRC. Additional steel rebars in the UHPFRC layer were applied for half of the specimens. The investigation demonstrated the effectiveness of the strengthening method, showing high resistance to high-dynamic loads. This behavior is attributed to the absorption and transfer of tensile stresses by the UHPFRC, that reduces penetration depth and damage, ensuring remaining load-bearing capacity after gunfire.
Numerical study of composite structures behavior under ballistic impacts
Authors: Nanema Billy Lorcendy Terrence , Mejri Mohamed , Ben Salah Nizar
Published: September 2024

The aim of this paper is to introduce a finite element study of the behavior of composite plates subjected to ballistic impacts. The work studies different configurations of laminated composite structures, with and without reinforcements, subjected to high-speed projectile impacts (400-1000 m/s). The investigation focuses on the response of different composite materials' stacking sequences, as well as the impact of epoxy carbon reinforced with carbon nanotubes and the behavior of hybrid sandwich structures made of Kevlar epoxy and glass epoxy. The purpose is to develop a strategy of composite material damage modelling, identify the effects of multi material hybridization, and the influence of reinforcement by carbon nanotubes, on the structures' resistance to ballistic impacts. Numerical simulation provides a detailed description of plate damage. Results show that composite plates with 2% carbon nanotubes (CNT) displays a better impact energy absorption compared to 1% CNT and plates without CNT. The study also revealed the hybridization sequences offering the greatest energy absorption.
Impact of different doses of esketamine on the incidence of hypotension in propofol-based sedation for colonoscopy: a randomized controlled trial
Authors: Fu Mengyue , Sheng Bo , Liu Rui , Li Yongjie , Chen Guizhen , Chen Hai , Chen Xuehan , Duan Guangyou , Huang He , Chen Jie , Chen Yuanjing
Published: September 2024

Background:

Hypovolemia is common in colonoscopy due to fasting and bowel preparation, and propofol itself can reduce systemic vascular resistance, resulting in relative hypovolemia. Therefore, hypotension is not a rare event during propofol-based sedation for colonoscopy.

Objectives:

Our objective was to explore the efficacy of esketamine as a sedative adjuvant in reducing the incidence of hypotension during colonoscopy.

Design:

This was a prospective randomized trial. The trial was registered with the Chinese Clinical Trial Registry (ID: ChiCTR 2100047032).

Methods:

We included 100 eligible patients who planned to receive a colonoscopy and randomly divided them into 4 groups with 25 patients in each group, which were propofol 2 mg/kg (Group P), propofol 1 mg/kg with esketamine 0.2 mg/kg (Group E1), propofol 1 mg/kg with esketamine 0.3 mg/kg (Group E2), and propofol 1 mg/kg with esketamine 0.4 mg/kg (Group E3). The hemodynamic and respiratory parameters were documented at various times during the procedure, including the patient’s entry into the endoscopic room (T0), the induction of sedation (T1), the insertion of the colonoscope (T2), the removal of the colonoscope (T3), and the awakening of the patient (T4). The primary outcome was the incidence of hypotension. Secondary outcomes were cardiovascular side effects other than hypotension, incidence of hypoxia, cumulative changes in cardiovascular and respiratory parameters, total propofol dosage, anesthesia recovery time, and satisfactory levels of both patients and endoscopists.

Results:

The incidence of hypotension in Group E1 (16%), Group E2 (16%), and Group E3 (12%) was significantly lower than in Group P (60%), with p values 0.003, 0.003, and <0.001 respectively. The cumulative changes in diastolic blood pressure and mean arterial pressure in Groups E1, E2, and E3 were significantly higher than in Group P ( p = 0.024, p < 0.001, p = 0.006, respectively). Cumulative changes in systolic blood pressure in Group E3 were significantly higher than those in Group P ( p = 0.012). The respiratory-related parameters were not statistically significant.

Conclusions:

This study showed that the application of 0.4 mg/kg esketamine in propofol-based sedation reduced the incidence of hypotension during colonoscopy while providing satisfactory sedation.
Strategic sourcing decisions: A Swiss bank responding to the dynamics of the core banking system market
Authors: Fischer Thomas A , Dibbern Jens
Published: September 2024

This case examines strategic challenges encountered by Berner Kantonalbank (BEKB), a prominent regional Swiss bank. The bank adapts its sourcing decisions related to its core banking system amidst the evolving landscape of the core banking software market. The narrative unfolds against unfulfilled strategic goals in a changing IT industry, revealing the complexities and decisions that shape BEKB’s approach to core banking system sourcing. In 2010, BEKB outsourced its core banking solution to Hewlett Packard (HP). This encompassed the transfer of all employees of its former subsidiary, RTC. RTC had formerly developed and operated BEKB’s core banking solution. The strategic move to outsource aimed to leverage HP’s capabilities for cost-effective core banking system operations. BEKB anticipated enhanced core banking system capabilities at a reduced cost, while HP sought to establish itself in the core banking software market. However, instead of expanding BEKB’s core banking system customer base, clients increasingly migrated to other providers. The evolving circumstances placed BEKB and HP in a mutual dependency, reaching a critical juncture when the bank decided to terminate the contract, which yielded a spectrum of strategic options. The decision taken endured for a few years. Subsequently, another strategic reevaluation was necessary. This case delves into the intricate interplay between sourcing decision and IT software product dynamics, offering perspectives from client and vendor. It sheds fresh light on strategic sourcing decision-making within the evolving landscape of an increasingly complex IT services environment.