bluuebunny/crossref_metadata_2025 huggingface dataset:
Can the ketogenic diet improve our dreams? Effect of very low-calorie ketogenic diet (VLCKD) on sleep quality
Authors: Barrea Luigi , Verde Ludovica , Di Lorenzo Cherubino , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna
Published: July 2023

Background

Obesity is a condition that is often associated with sleep disorders, including reduced sleep quality (SQ). Very low calorie ketogenic diet (VLCKD) has proven to be effective in the management of obesity and associated metabolic disorders. However, little is still known about the effects of this promising nutritional protocol on SQ. Thus, the purpose of this study was to investigate the short-term effect of VLCKD on SQ in women with overweight/obesity and if any changes, to identify the predictive factor that through VLCKD modified SQ.

Methods

Were consecutively enrolled a total of 324 subjects, who met the inclusion criteria and accepted to adhere to VLCKD. Assessment of nutritional status, including anthropometric measurements (height, weight, and waist circumference), bioelectrical impedance analysis (phase-sensitive system, 50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy Akern), high sensitivity C reactive protein levels (hs-CRP), and SQ were carried out at baseline and after 31 days of active stage of VLCKD. SQ was evaluated using the validated questionnaire Pittsburgh Sleep Quality Index (PSQI).

Results

In addition to the expected general improvement of anthropometric parameters and body composition, VLCKD improved significantly SQ, as demonstrated by the improvement of all parameters included in the PSQI questionnaire (p < 0.001). Both at baseline and after 31 days of active stage of VLCKD, the PSQI score was significantly associated with BMI, waist circumference, fat mass, fat free mass (p < 0.001 for all) and hs-CRP (p = 0.023). PhA was negatively associated with PSQI score only at baseline (p < 0.001). ∆% PSQI positively correlated with ∆% BMI, ∆% fat mass, ∆% hs-CRP (p < 0.001 for all) and negatively correlated with ∆% fat free mass (p < 0.001), and ∆% PhA (p = 0.031). In the multiple regression analysis ∆% fat mass represented the only predictor of changes in SQ after VLCKD. Finally, in the ROC analysis, a threshold value of ∆% fat mass > − 8.4% predicted improvement in SQ (p < 0.001).

Conclusion

In conclusion, VLCKD determines an improvement of SQ in women with overweight and obesity, that was mostly mediated by the reduction of fat mass related to this nutritional protocol.

Graphical Abstract
DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming
Authors: Yang Xuejiao , Wang Xiao , Yang Ying , Li Zhiyang , Chen Yunshuo , Shang Siqi , Wang Yueying
Published: July 2023

Background

DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogenesis through hypomethylation of some target genes associated with cell growth and differentiation. In this study, we investigated the function of DNMT3A R882H in the malignant progression of AML by regulating metabolic reprogramming.

Methods

Ultra-High Performance Liquid Chromatography–High Resolution Tandem Mass Spectrometry (UHPLC-HRMS/MS) was used to detect metabolites in the serum of mice harboring Dnmt3a R878H mutation and the wild-type Dnmt3a. Methylated DNA Immunoprecipitation Sequencing (MeDIP-seq) and RNA sequencing (RNA-seq) were used to analyze the levels of DNA methylation and mRNA expression of genes in mouse Gr1+ bone marrow cells respectively. The TCGA and GO databases were used to analyze the differential genes between human samples carrying the DNMT3A R882 mutation and the wild-type DNMT3A. Co-immunoprecipitation and immunoblotting were used to illustrate the binding levels of Cyclins-CDKs and CDK inhibitors including CDKN1A and CDKN1B. Flow cytometry was used to analyze the cell differentiation, division, apoptosis and cell cycle. The effect of NAMPT inhibition on leukemia was evaluated by using in vivo fluorescence imaging in NOG mouse model bearing OCI-AML3 cells.

Results

DNMT3A mutation caused high expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the nicotinamide adenine dinucleotide (NAD) salvage synthetic pathway, through DNA hypomethylation, and finally led to abnormal nicotinamide (NAM) metabolism and NAD synthesis. The NAM-NAD metabolic abnormalities caused accelerated cell cycle progression. Inhibition of NAMPT can reduce the binding degree between Cyclins-CDKs, and increase the binding interaction of the CDK inhibitors with Cyclins-CDKs complexes. Moreover, cells with high expression of NAMPT were more sensitive to the NAMPT inhibitor FK866 with a lower IC50. The inhibition of NAMPT can remarkably extend the survival time of tumor-bearing mice and reduce the infiltration of tumor cells.

Conclusions

Taken together, our data showed that DNMT3A mutation caused NAMPT overexpression to induce the reprogramming of NAM-NAD metabolism and contribute to abnormal proliferation, which provided a potential direction for targeted therapy at the metabolic level in AML with DNMT3A mutation.
Sex Steroids Regulate Liver Fat Content and Body Fat Distribution in Both Men and Women: A Study in Transgender Persons
Authors: Tebbens Marieke , Schutte Moya , Troelstra Marian A , Bruinstroop Eveline , de Mutsert Renée , Nederveen Aart J , den Heijer Martin , Bisschop Peter H
Published: July 2023

Context

Liver fat content and visceral fat volume are associated with insulin resistance and cardiovascular disease and are higher in men than in women.

Objective

To determine the effect of estradiol and testosterone treatment on liver fat and visceral fat in transgender persons.

Design

Open-label intervention study (SHAMVA) with a 1-year follow-up.

Setting

Gender clinic in a hospital.

Patients

8 trans women and 18 trans men receiving hormone treatment.

Interventions

Trans women received an antiandrogen and after 6 weeks estradiol was added. Trans men were randomized to receive triptorelin, testosterone, and anastrozole for 12 weeks or triptorelin and testosterone for 12 weeks, followed by only testosterone until week 52.

Main outcome measures

Liver fat content, visceral and abdominal subcutaneous fat volume, measured by magnetic resonance spectrometry or imaging at baseline, 6, 8, 18, and 58 weeks in transwomen or at baseline; at 6 and 12 weeks in trans men with anastrozole; and at 52 weeks in trans men without anastrozole.

Results

In trans women, liver fat content decreased by 1.55% (−2.99 to −0.12) after 58 weeks, compared to week 6. Visceral fat did not change. In trans men with anastrozole, the liver fat content and visceral fat volume did not change. In trans men without anastrozole, after 52 weeks, liver fat content increased by 0.83% (0.14 to 1.52) and visceral fat volume increased by 34% (16 to 51).

Conclusions

Sex hormones regulate liver fat content and visceral fat in men and women.
Predictors of Early Versus Late Recurrence in Invasive Lobular Carcinoma of the Breast: Impact of Local and Systemic Therapy
Authors: Rothschild Harriet T. , Clelland Elle N. , Mujir Firdows , Record Helena , Wong Jasmine , Esserman Laura J. , Alvarado Michael , Ewing Cheryl , Mukhtar Rita A.
Published: July 2023

Background

Invasive lobular carcinoma (ILC) of the breast is known for high risk of late recurrence, yet some patients still recur within 5 years of diagnosis. Determining factors associated with early/late recurrence could help tailor treatment and surveillance strategies.

Methods

Using an institutional database, we evaluated patients with ILC and ≥ 5 years of follow-up or recurrence within 5 years. We used multivariate logistic regression and the Kaplan-Meier method to evaluate which clinicopathologic features and treatment strategies were associated with recurrence < 5 years since diagnosis versus recurrence ≥ 5 years since diagnosis. Additionally, we explored the association between Clinical Treatment Score 5 (CTS5) with early versus late recurrence.

Results

Among 513 cases of stage I–III ILC, there were 75 early and 54 late recurrences during a median follow-up period of 9.4 years. Early recurrence was associated with larger tumors (mean 4.2 cm vs. 2.9 cm, p < 0.0001), higher incidence of > 3 positive nodes (32.4% vs. 9.11%, p > 0.0001), and more aggressive tumor biology (low/negative progesterone receptor expression, higher grade, and higher Ki67). Late recurrence was associated with younger age (mean 55.6 vs. 59.2 years, p = 0.037) and elevated body mass index (BMI > 25 kg/m2 in 60.1.0% vs. 45.4%, p = 0.021). Omission of adjuvant endocrine therapy or radiotherapy after lumpectomy conferred increased risk of early rather than late recurrence.

Conclusion

Factors related to tumor aggressiveness and treatment were associated with early recurrence, whereas patient related factors were related to late recurrence. These data may help guide treatment strategies and surveillance approaches for patients with ILC.
The need to safeguard cultural heritage against climate change
Authors: Sulaj Anila , Kadiu Brixhilda , Terpollari Arben
Published: July 2023

The biggest challenges of our time are climate change and the preservation of cultural heritage. In the Albanian context, promoting innovative ways and incentives for the traceability of cultural heritage is seen as a solution to regenerate new insights to support and safeguard culture. The aim of the paper is to assess the threats posed by climate change and other risks in order to prevent deterioration, enhance protection and reinforce related policies. The interdisciplinary research presents different aspects of securing sustainable development through culture and cultural heritage. The findings indicate good practices and innovative measures for the protection or Albanian cultural heritage in relation with climate change. Moreover, the discussion is placed within the role of local and policy-making processes in validating and promoting solution for the effective resilience of cultural heritage against climate change through this multidisciplinary research.
Makna “Bintang Sebagai Alat Pelempar Setan” dalam al-Mulk ayat 5: Studi Interkonektif Tafsir dan Data Astronomis
Authors: Fajri Romadhon Nur
Published: July 2023

This paper aims to further explore the meaning of "stars as a tool/weapon throwing demons" contained in several verses of the al-Quran, including al-Mulk verse five. The need for further study of this verse is motivated by the potential contradiction between the meaning of the verse and modern scientific knowledge that is developing today, especially with the science of astronomy. The translation of the word star and its function of throwing demons, is a textual meaning that is not in accordance with the astronomical interpretation of the phenomenon of falling celestial bodies. Because what falls astronomically is not a star, but a meteoroid which is an asteroid debris where this fragment can come from planetary debris or the rest of planet-forming material and sometimes not only from planetary debris but also from satellites and comets. So the question is what is meant by the star in the verse? And what is meant by the demon thrower. In the process, the researcher uses interconnection theory to examine the existing data. With the interconnection theory, it is possible for data that is naqli (religious proposition) to be linked with other data internally -such as the Prophet's hadith, the aṡar of friends of the scholars' opinions-, as well as externally, such as astronomical data regarding the history of meteors and comets. The results of this study indicate that, in terms of the vocabulary used in the verses of the al-Quran, najm, kawkab, and other vocabularies can indeed be interpreted not only as stars in the present sense, but also other celestial bodies, such as meteors and planets. So that only interpreting the vocabulary in stars results in reducing the scope of meaning of the vocabulary itself. In addition, various hadiths that explain al-Mulk verse 5 show that what is meant by a large planet is not the material thrown by the jinn who tap the sky news, but meteoroids which are asteroid fragments. The use of the word najm is precisely to refute the ignorant myth about meteor showers. So, it is precisely the use of the vocabulary in the verse to expand the Arabic imagination when it comes to celestial bodies. Finally, epistemologically it is necessary to admit that astronomy does not allow to reveal the full meaning of the sentence, because the phenomena of celestial bodies in the Qur'an have several functions, including functions that cannot be understood by human reason.
Pan-European study of genotypes and phenotypes in the Arabidopsis relative Cardamine hirsuta reveals how adaptation, demography, and development shape diversity patterns
Authors: Baumgarten Lukas , Pieper Bjorn , Song Baoxing , Mane Sébastien , Lempe Janne , Lamb Jonathan , Cooke Elizabeth L. , Srivastava Rachita , Strütt Stefan , Žanko Danijela , Casimiro Pedro GP , Hallab Asis , Cartolano Maria , Tattersall Alexander D. , Huettel Bruno , Filatov Dmitry A. , Pavlidis Pavlos , Neuffer Barbara , Bazakos Christos , Schaefer Hanno , Mott Richard , Gan Xiangchao , Alonso-Blanco Carlos , Laurent Stefan , Tsiantis Miltos
Published: July 2023

We study natural DNA polymorphisms and associated phenotypes in the Arabidopsis relative Cardamine hirsuta. We observed strong genetic differentiation among several ancestry groups and broader distribution of Iberian relict strains in European C. hirsuta compared to Arabidopsis. We found synchronization between vegetative and reproductive development and a pervasive role for heterochronic pathways in shaping C. hirsuta natural variation. A single, fast-cycling ChFRIGIDA allele evolved adaptively allowing range expansion from glacial refugia, unlike Arabidopsis where multiple FRIGIDA haplotypes were involved. The Azores islands, where Arabidopsis is scarce, are a hotspot for C. hirsuta diversity. We identified a quantitative trait locus (QTL) in the heterochronic SPL9 transcription factor as a determinant of an Azorean morphotype. This QTL shows evidence for positive selection, and its distribution mirrors a climate gradient that broadly shaped the Azorean flora. Overall, we establish a framework to explore how the interplay of adaptation, demography, and development shaped diversity patterns of 2 related plant species.
Transmission of Knowledge
Authors: Kuch Ulrike
Published: July 2023

In this article, Ulrike Kuch suggests switching to film theory and history to think about architecture. With the help of director Sergei Eisenstein and architect Le Corbusier she explores how architecture and film share an intensive relationship with images. Montage as a cinematic technique to attach images reveals characteristics of architecture that architects might not have been aware of - the relevance of gaps, for example. Thus, images are entities with which to transmit knowledge from film to architecture and back, while montage is the practice of working with images and their inherent knowledge.
Bayesian and non-Bayesian estimation of dynamic cumulative residual Tsallis entropy for moment exponential distribution under progressive censored type II
Authors: Alyami Salem A. , Hassan Amal S. , Elbatal Ibrahim , Elgarhy Mohammed , El-Saeed Ahmed R.
Published: July 2023

The dynamic cumulative residual (DCR) entropy is a helpful randomness metric that may be used in survival analysis. A challenging issue in statistics and machine learning is the estimation of entropy measures. This article uses progressive censored type II (PCT-II) samples to estimate the DCR Tsallis entropy (DCRTE) for the moment exponential distribution. The non-Bayesian and Bayesian approaches are the recommended estimating strategies. We obtain the DCRTE Bayesian estimator using the gamma and uniform priors via symmetric and asymmetric (linear exponential and general entropy) loss functions (LoFs). The Metropolis–Hastings algorithm is employed to generate Markov chain Monte Carlo samples from the posterior distribution. The accuracy of different estimates for various sample sizes, is implemented via Monte Carlo simulations. Generally, we note based on the simulation study that, in the majority of cases, the DCRTE Bayesian estimates under general entropy followed by linear exponential LoFs are preferable to the others. The accuracy measure of DCRTE Bayesian estimates using a gamma prior has smaller values than the others using a uniform prior. As sample sizes grow, the Bayesian estimates of the DCRTE are closer to the true value. Finally, analysis of the leukemia data confirmed the proposed estimators.
The ‘Lying Down Menology’: Instructions for a Year of Auspicious Dreams
Authors: Hätinen Aino
Published: July 2023

The ‘Lying Down Menology’ is a previously unedited text belonging to the corpus of Mesopotamian hemerological and calendrical texts. It contains a set of ritual instructions about hygiene, clothing, food and drink, sexual relations, and sleeping for each of the twelve months of the year; the goal is to obtain an auspicious dream. This menology was one of the texts used to compile the royal hemerology ‘Inbu bēl arḫi’, and its transmission can be followed to late period Babylonia where it is associated with the micro-zodiac.
MEMBUDAYAKAN CARA MEMBUAT KEPUTUSAN BERTERASKAN MAQASID SYARIAH DALAM PENGURUSAN ORGANISASI ISLAM
Authors: T.M Tuan Sidek , Ismail
Published: July 2023

Decision making is an important matter in the management of the organization including the management of Islamic organizations. The decision-making process takes place at various levels of management. A good decision will make the affairs of an institution run smoothly, the benefits are felt by various parties, reduce conflict and produce more effective management. Thus, a conceptual article entitled Cultivating Method of Decision-making Based on Maqasid Syariah in Islamic Organizational Management was written to suggest efforts to cultivate a decision making based on contemplating the concept and application of maqasid syariah. This article explains the concept and application of maqasid syariah and its suitability in helping parties involved in Islamic management to cultivate a way of making decisions based on maqasid syariah. Hopefully this article can help promote the method of thinking and decision making based on one of the treasures of Islamic intellectuals as well as helping the management of Islamic organizations to improve and remain in line with the changing times.
 
Membuat keputusan adalah suatu perkara yang penting dalam pengurusan organisasi termasuklah dalam pengurusan organisasi Islam. Proses membuat keputusan berlaku pada pelbagai peringkat pengurusan. Keputusan yang baik akan menjadikan urusan sesebuah institusi berjalan dengan lancar, manfaatnya dirasai oleh pelbagai pihak, mengurangkan konflik serta menghasilkan pengurusan yang lebih efektif. Sehubungan dengan itu, tulisan berbentuk konsep yang bertajuk Membudaya Cara Membuat Keputusan Berteraskan Maqasid Syariah dalam Pengurusan Organisasi Islam ditulis untuk mencadangkan usaha membudayakan cara membuat keputusan berpandukan kepada penghayatan terhadap konsep dan aplikasi maqasid syariah. Tulisan ini menjelaskan konsep dan aplikasi maqasid syariah dan kesesuiannya dalam membantu pihak yang terlibat dalam pengurusan Islam untuk membudayakan cara membuat keputusan berasaskan maqasid syariah. Semoga tulisan ini dapat membantu mempromosi kaedah berfikir dan membuat keputusan berpandukan salah satu khazanah intektual Islam di samping dapat membantu pengurusan organisasi Islam menjadi bertambah baik dan kekal bersesuaian dengan perubahan zaman.
Edmund Siemers
Authors: Gerhardt Johannes
Published: July 2023

Als schöpferischer Unternehmer war er einer der Pioniere des Petroleumhandels in Deutschland. Später reüssierte er als Importeur von Chilesalpeter und baute eine eigene Schiffsflotte auf. Und schließlich wurde er Bauunternehmer und Großgrundbesitzer im Norden Hamburgs. Doch wirklich bekannt ist Edmund Siemers durch seine beiden großen Stiftungen geworden: 1896 Edmundsthal-Siemerswalde in Geesthacht, eine der ersten Lungenheilstätten in Deutschland, und 1907 dann das Vorlesungsgebäude auf der Moorweide, bis heute Sinnbild für „die Universität“ in Hamburg. Edmund Siemers’ Leben ist gleichermaßen mit der hamburgischen,deutschen und transatlantischen Wirtschaftsgeschichte des 19. und beginnenden 20. Jahrhunderts verknüpft. Geradezu idealtypisch verkörpert er einen Stifter aus dem hamburgischen Großbürgertum. Die erste Biographie des „Carnegie Hamburgs“, der auch als Donator und Kuratoriumsmitglied der Hamburgischen Wissenschaftlichen Stiftung in Erscheinung trat.
Vejez en la población Mazahua: pérdida de rol y estatus social en contextos de pobreza
Authors: Arcos Miranda Evaristo
Published: July 2023

La definición de un rol y un estatus social es fundamental en la vida de las personas, pero estas representaciones sociales intrínsecas pueden modificarse con la llegada de la vejez. Se analizó el rol y estatus social de senectes mazahuas de San Felipe del Progreso, Estado de México, a partir de una etnografía efectuada en el año 2022, con lo que se detectó una tendencia hacia su pérdida en el grupo de estudio, vinculada en forma directa con su situación de pobreza y dependencia, expresándose en distintas formas de abandono, exclusión y discriminación.
The impact of preconception counselling on pregnancy outcomes and maternal health
Authors: Baoum Shada Omar , Alaklabi Nouf Mohammed , Ayoub Yazan Adnan , Alresheedi Hend Ali , Alalshaikh Zahra Ahmed , Alshahrani Nada Mohammed , Alotibi Aljohraha Mohammed , Albahrani Kumail Abdulmonem , Alghanim Manar Ali , Almutairi Jawaher Fahad , Almagati Hanan Thenayan
Published: July 2023

Reproductive health is a global concern, characterized by high rates of maternal and infant mortality. Preconception counseling is a comprehensive approach aimed at improving pregnancy outcomes and maternal health. It involves addressing pre-existing medical conditions, promoting lifestyle modifications, and providing education and support to women before conception or during the interconception period. Tailoring counseling to individual needs and risk factors is crucial for optimal outcomes. Although further research is needed to assess the sustained effects of behavioral changes and overall impact, preconception counseling holds significant potential in promoting healthier pregnancies and improving the well-being of women, infants, and families. By prioritizing research in this field, we can better understand and utilize the benefits of preconception counseling, ultimately contributing to the global enhancement of reproductive health. While the impact of preconception counseling on long-term outcomes requires further research, its potential in promoting healthier pregnancies and improving the well-being of women, infants, and families is evident. It has the capacity to address not only the physical aspects of reproductive health but also the emotional, social, and environmental factors that contribute to overall well-being.
State Interest and the Vicious Circle of the Police: Michel Foucault's Model
Authors: Makarenko V.P.
Published: July 2023

M. Foucault developed a model of the police as a political technology that sought to manage in accordance with the state interest (hereinafter GI). This model is based on the analysis of many phenomena of being and thinking. These include: temporal-spatial differences in the understanding of the term police during the XV–XVIII centuries; the connections of the police of Italy, Germany and France with the general balance of Europe; the genesis of the police in these countries to establish the national specifics of police science; the genesis of the concept of state benefit as a bureaucratic innovation and the basis of the utopia of the police state. Foucault established that for two hundred years (XV–XVI centuries), the term police was understood in three ways: as communities under the control of the authorities, specific acts of management, positive overall results of management. However, in the next two hundred years (XVII–XVIII centuries) the police began to be called a set of tools that allow controlling the relationship between social order and the growth of state forces in order to ensure a link between the state's well-being and the happiness of all citizens. With this approach, the police qualified as a space-time synthesis of beauty, order and strength, which is guaranteed by the police as a set of “laws and regulations concerning the internal life of the State and seeking to strengthen and increase the power of this state, seeking to achieve the correct use of its forces”. The purpose of the article is to abstract the material of two Foucault lectures to systematize the real variety of aspects of the main problem indicated in the title. On this basis, the problem-heuristic potential of this fragment of M. Foucault's political theory is reconstructed.
Possibilities of a Network Approach in the Study of Regional Branches of Political Parties
Authors: Savenkov R.V. , Stredinina V.V.
Published: July 2023

The article attempts to analyze the number and content of interactions of the Voronezh political parties in 2022 with other political and public actors. Empirical data were collected using the content analysis method, and the network approach was chosen as the conceptual framework of the study. The main source was the official websites of the regional branches. According to the results of the study, the regional branch of the “United Russia” party became the most active in 2022. A relatively high frequency of contacts between the Liberal Democratic Party of Russia and the executive authorities of the Voronezh region has been recorded.
Comparative Study of M20 and M25 grades of Concrete by ACI, DOE and BIS Methods of Mix Design Using Crushed Aggregate
Authors: Dr. S.K Verma Ravinder Singh,
Published: July 2023

The basis of this paper is to analyse comparative study of different testing methods of concrete mix design of M20 and M25 grades. Different structures are being considered for testing the parameters relating to designed testing methods. Design mix is process of amalgamating different composition of material so as to adhere the final composed material with required compressive strength, practicability, and resilience. The appropriate mixture of cement, sand aggregate and water are fabricated to achieve desired design mix. The test methods are internationally adopted accordingly the countries requirement and their acceptability of designing their structures. The specimens tested was compressive test- cube test, flexural test-beam test and split tensile test-cylinder test. The design method considered for testing was BIS method, DOE method & ACI method for defining the structure design for concrete. The study shows designs of concrete derived from DOE testing method are more superior to other two methods which were used for designing of concrete. This analysis is witnessed for overall strength and behaviour of testing specimens which were used for testing, and this is relevant to both grade which was considered i.e. M20 and M25. The mean strength analysis for ACI method in case of M25 was failed to attain the desired result which was marked for design parameter, thus failed test for M25 relating to mean strength in case of ACI. The specimens i.e. cubes, beams, and cylinder was moulded for both grades M20 and M25 accordingly there strength parameters. The curing was taken up at 7 day and 28 day process follow-up which is standard norm for all methods. The comprehensive analysis of both curing periods were listed out and thus comparison of strengths for all moulds were evaluated for better insight into the strength relation with curing period. It’s is approximately similar for all methods thus showing curing period is independent of test method used. The DOE method showed best results among the listed methods taken up for study and DOE has competitive advantage in strength and its performance.
THE URGENCY OF DIGITAL BROADCASTING FOR PUBLIC INTEREST TO GET QUALITY BROADCASTING SERVICES
Authors: Saudi Yusron , Rahmawati Endang
Published: July 2023

The transition from analog to digital broadcasting has been mandated for West Nusa Tenggara (NTB) Province. Numerous stakeholders are involved in the dissemination of information about the relocation of broadcasting in NTB. The spread of information about broadcasting migration and the pressing need for digital broadcasting are investigated in this study using the qualitative technique. The study's findings show that the government used a number of broadcasting organizations (TV and radio) to disseminate information about the migration to digital television in NTB. The public has endorsed this in order to acquire broadcasting services of a higher caliber. This switch to broadcasting is the best move for making optimum use of frequency and fostering the development of the digital economy and industry.
Semi-analytical Modeling of Pyrolysis Front and Ignition Temperatures of Thermally Reactive Single Solid Particles
Authors: Haseli Yousef
Published: July 2023

A semi-analytical approach is developed for predicting pyrolysis front temperature in a solid undergoing thermal decomposition. The pre-reaction heating stage is described using an analytical formulation and invoking the concept of thermal penetration depth. The solution for the solid conversion stage accounts for decomposition enthalpy, convective flow of volatiles, and a reaction front characterized by a uniform temperature that progresses toward the inner layers. This method incorporates empirical relations into the analytical model. Two scenarios are considered. First, the solution of the pyrolysis model combined with the data of conversion time versus external heat flux leads to an algebraic expression that reveals the existence of a maximum pyrolysis-front temperature. Explicit relations are derived for both the extremum pyrolysis temperature and optimum applied heat flux. In the second case, an expression is derived for the ignition temperature of a solid fuel by incorporating ignition delay time measurements into the heating stage model. The newly derived expression allows to describe the ignition temperature as a function of the Biot number and external heat flux. The relation obtained for the ignition temperature explains the experimental trends reported in some previous studies where two local extremums were observed for the ignition temperature in the absence of volatiles reactions.
Confidential Secure Certified Notification System Using Rejectable Identity Tokens and Identity-based Cryptography
Authors: Imam Mohsin , Meena Harsh
Published: July 2023

The use of blockchain technology in various e-commerce applications, such as the establishment of certified notifications, has emerged. This particular service enables a user, assuming the role of a sender, to substantiate the transmission of specific data to a recipient. By leveraging blockchain technology, we can capitalize on its transparent and decentralized nature to ensure the genuineness and integrity of notifications. Our proposal incorporates the deployment of Soulbound tokens (SBTs), which are unique NonFungible Tokens (NFTs) incapable of being transferred or traded to other users. Additionally, we enhance the ERC-721 standard to encompass the functionality where the recipient has the option to decline a token, enabling selective acceptance of SBTs. By representing certified notifications as Rejectable SBTs (RejSBT), we establish a mechanism to monitor instances when a sender dispatches a notification and when the recipient acknowledges it, offering both non-repudiation of origin (NRO) and reception (NRR) verifications. Once the recipient accepts the RejSBT signifying ownership of a notification, we employ Identity-based Cryptography to facilitate the owner's decryption of the confidential information encoded within the RejSBT
Phytochemical Screening and Evaluation of Contractile Effects of the Aqueous and Hydroethanolic Extracts of Anastatica hierochuntica L. (Brassicaceae) on Pregnant Mice Isolated Myometrium
Authors: Belem-Kabré Wendkouni Leila Marie Esther , Nitièma Mathieu , Odjo Blondine Saïdath , Maman Noura Oumarou , Yaro Boubacar , Kaboré Boukaré , Somda Gaétan , Traoré Kadiatou Tata , Koala Moumouni , Ilboudo Sylvain , Ouédraogo Moussa , Kabré Elie , Ouédraogo Noufou
Published: July 2023

Anastatica hierochuntica L. (Brassicaceae) has been claimed to treat various conditions including complicated childbirth. The principal objective of this research was to provide scientific evidence on the contractile effect of the aqueous and hydroethanolic extracts of the whole plant from A. hierochuntica during labor. Qualitative and quantitative methods helped identify and quantify the phytoconstituents in both extracts. The antioxidant activity was studied using four standard methods. The inhibitory power of the extracts on pro-inflammatory enzymes such as 15-lipoxygenase and phospholipase A2 was determined. The contractile effects of the extracts were evaluated using isolated pregnant mice uteri. Steroids, triterpenoids, flavonoids, tannins, coumarins, and reduced compounds were identified in both extracts. The extracts demonstrated the ability to reduce oxidative stress. The hydroethanolic extract displayed the most significant anti-lipoxygenase activity with an IC50 value of 55.82 ± 1.15 µg/mL. The lethal dose (LD50) of extracts was estimated to be superior to 2000 mg/kg bw. The ability of the samples to produce one cm amplitude of contraction at 50% effective concentrations (EC50) was 1.51 ± 0.08 mg/mL for aqueous extract and 3.57 ± 0.61 mg/mL for hydroethanolic extract. These findings could provide evidence for using Anastatica hierochuntica to augment labor.
Professional identity development, self-efficacy and sense of coherence in Nursing Education
Authors: Vabo Grete , Haugen Tommy
Published: July 2023

Background.
For nursing students, it is important to learn how to think as a nurse and have a professional identity development. Nursing students are required a safe learning environment and reflection time to enhance their professional identity. The purpose of this study was firstly to examine nursing students’ professional identity development during education. Secondly it was to investigate the predictive value of self-efficacy and Sence of Coherence (SOC) on the professional identity of nursing students also during the education.
Methods.
A longitudinal study design was used to explore this development during education time. The relationship between sense of coherence, self-efficacy and professional identity were explored. Data were collected through self-reported questionnaires, three times. Statistical software jamovi 1.2.9 was used for the data analysis. Repeated measures ANOVA, and a multiple linear regression analysis were performed.
Result.
Professional identity development increased over time, and changes from Time 1–Time 3 were statistically significant. The only statistically significant predictor was students’ self-efficacy.
Conclusion.
To integrate self-efficacy when preparing the curriculum for nursing students, can lead to more competent nurses, and further on professional nurses with a higher level of professional identity.
Association between serum eicosapentaenoic acid/arachidonic acid ratio and overall survival in patients with non-small cell lung cancer treated with pembrolizumab
Authors: Tanaka Ikue , Yano Yukihiro , Mori Masahide , Manabe Satoru , Fukuo Keisuke
Published: July 2023

This pilot study was based on an analysis of the dietary patterns of patients with non-small cell lung cancer (NSCLC) undergoing initial pembrolizumab, an immune checkpoint inhibitor (ICI), treatment in the month prior to treatment and an analysis of serum fatty acid fractions. Their association with ICI treatment efficacy was investigated. The results of this study showed that long-term survivors (those who survived for ≥ 3 years) consumed significantly more seafood than short-term survivors (those who survived for < 3 years). Furthermore, the serum levels of eicosapentaenoic acid (EPA) and the ratio of EPA to arachidonic acid (EPA/AA) were higher in long-term survivors than those in short-term survivors. Interestingly, the group with a high serum EPA/AA ratio had significantly higher overall survival rate after ICI treatment compared with the group with a low serum EPA/AA ratio. In conclusion, the serum EPA/AA ratio may be a useful biomarker for determining the efficacy of ICI treatment, and supplements that increase the serum EPA/AA ratio could serve as new nutritional treatments for enhancing the efficacy of ICI treatment. However, further large-scale case and intervention studies are required.
Analysis of the weighted conical and v-line Radon transform
Authors: Duy Nguyen N.
Published: July 2023

In this article, we investigate the weighted conical Radon transform, a novel class of Radon transforms that takes into account the attenuation effect by integrating a function over circular cones. This transform has significant applications in nuclear tomography imaging, the nuclear industry, and homeland security. We propose new inversion formulas for the weighted conical Radon transform, which an explicit formula and a formula based on convolution frames. Furthermore, we provide numerical simulations designed for 2D situation.
Effect of Surface Chemistry of Inorganic Materials on Structures and Fracture Behaviours of Epoxy Resin within Nanometres of Adhesive Interfaces
Authors: Jinnai Hiroshi , Miyata Tomohiro , Sato Yohei , Wang Hsiao-Fang , Kumagai Akemi , Kawagoe Yoshiaki , Shirasu Keiichi , Kinoshita Sora , Yoshida Kaname , Huang Hsin-Hui , Okabe Tomonaga , Mizukami Masashi , Hagita Katsumi , Mizoguchi Teruyasu
Published: July 2023

Adhesion and delamination between polymers and inorganic materials are being widely utilized. However, the mechanisms underlying the influence of inorganic material surface chemistry on polymer structures and fracture behaviours near adhesive interfaces are not fully understood; this was studied herein using electron microscopy and molecular dynamics simulations. We prepared adhesive interfaces between epoxy resin and silicon substrates with varying surface chemistries (OH and H terminations) with a smoothness of < 1 nm. The epoxy resins within sub-nanometre distance from the adhesive interfaces exhibited distinct amine-to-epoxy ratios, cross-linked network structures, and adhesion energies. The OH- and H-terminated interfaces exhibited cohesive failure and interfacial delamination, respectively. The substrate surface chemistry impacted the cross-linked structures of the epoxy resins within several nanometres of the interfaces, which resulted in different fracture behaviours and bond strengths. This will help develop durable adhesion with epoxy resins, and potentially help achieve weight reduction in vehicles and other products.
Copper laser welding from 3 m/min to 35 m/min at 8 kW using beam shaping with Multi-Plane Light Conversion
Authors: Kumar Avinash , Orieux Adeline , Gaillard Nicolas , Lamaitre David , Adrien Adrien , Pallier Gwenn , Labroille Guillaume
Published: July 2023

Copper is a widely used material in the electric vehicle industry due to its excellent electrical and thermal conductivity. However, welding copper can be challenging due to its high thermal conductivity and low absorptivity at 1 µm. We discuss a new method of copper laser welding that utilizes beam shaping based on Multi-Plane Light Conversion (MPLC) technology to stabilize the melt pool for a broad range of speed and power. The welding performance of different shapes based on MPLC technology is discussed including welding penetration depth from 4 to 8 kW and from 3 to 15 m/min. In addition, live X-ray imaging was performed, as well as post-processing X-ray analysis showing that no pores were inside the welds. The X-ray analysis including pore count and capillary length for different welding parameters is described. The developed system allows for deep penetration welding up to 2.8 mm at 8 kW and 3 m/min, which may be applied to busbar welding. Deep penetration welding up to 35 m/min at 8 kW was also achieved, paving the way for applications such as hairpin welding. The welding performance of the MPLC technology-based system versus beam shaping based on a dual-core fiber laser technology system in similar conditions and no beam-shaping is shown. It includes a process window comparison with welding penetration depth and pore analysis. It demonstrates that the MPLC system enables high-quality welding at both lower and higher speeds.
The Clinical Outcome of Emergency Superficial Temporal Artery-to-Middle Cerebral Artery Bypass in Acute Ischemic Stroke with Large Vessel Occlusion: A cohort study and meta-analysis
Authors: Guo Lei , Yang Li , Li Chunling , Zeng Yi , Xu Ruxiang , Wang Zhengyu , Jiang Chonggui
Published: July 2023

Objective
We conducted a cohort study to evaluate the clinical outcome of emergency STA-MCA in AIS-LVO and a meta-analysis to assess the clinical outcome of STA-MCA performed to treat early AIS.
Methods
We recruited newly diagnosed patients with AIS-LVO from January 2019 to March 2022. The patient population was divided into the following two groups: the STA-MCA group and the non-STA-MCA group. Neurological status and outcomes were respectively assessed with the National Institutes of Health Stroke Scale (NIHSS) in the acute phase and the modified Rankin Scale (mRS) during the follow-up. Besides, a meta-analysis of all reported clinical studies was conducted to evaluate the effect of STA-MCA in patients with AIS.
Results
Our cohort study included 56 patients. The improvement in neurological status was more evident in the STA-MCA group than in the non-STA-MCA group at two weeks after onset (p = 0.030). Multivariable logistic regression analysis indicated that the NIHSS score at two weeks after onset (OR: 0.840; 95% CI: 0.754–0.936, p = 0.002) was the most important factor contributing to a good outcome. In the meta-analysis, the pooled rate (n = 7) for achieving a good outcome (mRS < 3) was 67% (95% CI: 57% − 77%, I2 = 44.1%) at follow-up points.
Conclusions
The meta-analysis revealed that STA-MCA for patients with mild to moderate AIS can be judged effective. However, our cohort study suggested that STA-MCA bypass does not seem to improve the prognosis of patients who suffer from AIS-LVO.
Robustness analysis of exponential stability of fuzzy inertial neural networks
Authors: Fang Wenxiang , Xie Tao
Published: July 2023

This paper characterizes the robustness of exponential stability of fuzzy inertial neural network which contains time delays or stochastic disturbance through the estimation of upper limits of perturbations. By utilizing Gronwall-Bellman lemma as well as some inequality techniques, the limits of both time delays and stochastic disturbances are derived in this paper which can make the disturbed system keep exponential stability. And the constraints between the two types of disturbances are provided in this paper. Examples are offered to validate our results.
A Counterpart to the St. Petersburg Paradox
Authors: Sims Justin Tyler
Published: July 2023

A paradox of expected utility theory similar to the St. Petersburg paradox is presented, which arises with agents whose risk aversion decreases quickly enough as they gain wealth according to a uniform payoff scheme with positive but diminishing probability premium. It is shown that while both paradoxes require unbounded utility, this counterpart has a more satisfactory resolution through temporal dis- counting than the St. Petersburg paradox. Finally, it is shown that this is mirrored in more realistic settings with prospect theory agents. This indicates that the two paradoxes are distinct and that account- ing for time preference is important in models that allow unbounded utility.
Modern problems of higher education development in Russia
Authors: Kolin K. K.
Published: July 2023

The purpose of the research. The article is devoted to the analysis of the main directions of development of the higher education system in Russia, which is currently under modernization and should receive new content in order to become adequate to the strategic goals and national priorities of our country in the new geopolitical conditions. The lessons of Russia’s special military operation in Ukraine have shown the need to modernize our country’s higher education in the interests of developing the military-industrial complex and ensuring national security. At the same time, in order to improve the quality of education of engineering specialists, they also need systemic and humanitarian knowledge based on the latest achievements of domestic and world science. This knowledge is also necessary for other specialists with higher education in order for them to form a systemic type of thinking, which is required today to adequately counter the new challenges and threats of the 21st century.

Materials and methods. In the course of the research, review publications were used on the current state of ensuring Russia’s national security by the necessary specialists with higher education, as well as on the projected challenges and threats to Russia’s national security, the counteraction of which requires adequate changes in the education system.

The results of the study. As a result of the research, the structure of priority directions for the development of the higher education system in Russia for the period up to 2030 has been determined. The implementation of these directions will make this system more adequate to Russia’s strategic goals and national priorities for this period in the new geopolitical conditions. It is shown that one of the urgent tasks is the formation of a comprehensive information education system in our country, the conceptual foundations of which have been developed in the Russian Academy of Sciences. The tasks of the education system for the formation of a culture of safety in society are also considered – a new direction in the development of culture, which is already being formed and is a necessary condition for the further safe development of world civilization.
Evaluation of the Interaction between Ricin Protein and Quercetin using
Different Analytical Methods
Authors: Martínez-Ceniceros Mayra Cristina , Nevarez-Prado Lenin Omar , Neder-Suarez David , Sandoval-Salas Fabiola , Rodríguez-Valdez Luz María , Landeros-Martínez Linda-Lucila , Bernal-Alvarado Karla , Hernández-Ochoa León
Published: July 2023

Background:

Ricin is the most toxic protein known. It is part of the ribosome-inactivating
proteins, RIPs, type 2, which has generated importance in his research; it is possible to detoxify this
protein with phenolic compounds; however, it is essential to understand how this detoxification occurs.
To analyze using electrophoresis, UV-visible spectroscopy, and high-performance liquid chromatography
(HPLC) the protein ricin with the flavonol quercetin, understanding the detoxification
process.

Methods:

The UV-visible analysis was performed on both the supernatant and the precipitate of the
samples; these results were analyzed using one-factor analysis of variance (ANOVA) and a Tukey test
with a significance level of 0.05.

Results:

34.9 μg/mL of total protein and 4.2 μg / mL of ricin were obtained in the extraction method.
Eight interactions were carried out, and all presented precipitation, observing through the electrophoresis
technique a decrease in the bands corresponding to the protein; these results were analyzed with
HPLC observing a decrease in the size of the area of the peaks in the chromatograms.

Conclusion:

The results obtained in this study suggest an agglomeration of the protein, generating a
precipitate that could benefit the protein's inactivation as a detoxification process.