bluuebunny/crossref_metadata_2025 huggingface dataset:
In Situ Growth of NiCo Layered Double Hydroxide on Biomass Waste‐Based Substrate: A Novel Material with 3D Interconnected Structure as Electrodes for Supercapacitors
Authors: Qu Keqi , Wang Weicong , Lu Xuejun , Huang Zhanhua , Liu Jian
Published: October 2022

Next‐generation energy storage systems require green and renewable electrodes with a high specific capacity, which combine biomass waste and bimetallic hydroxide synergically to satisfy environmental enhancements and economic benefits. Herein, a novel approach to improving the electrical conductivity of bimetallic materials by in situ growing NiCo layered double hydroxides (LDHs) with pseudocapacitance capability on KMnO4‐activated fungus bran‐derived carbons (FBCs) is reported, achieving improved electrochemical performance in supercapacitors (SCs). The hierarchical porous FBC substrate contributes to the homogeneous growth of the LDHs and high electronic and ionic conductivity. The optimal composite (FBC/NCL‐3) with a 3D interconnected structure provides a specific capacitance of 1938 F g−1 at a current density of 1 A g−1. Correspondingly, the hybrid battery‐SC device composed of FBC/NCL‐3 and FBC provides favorable stability (76% specific capacity retention at 5 A g−1 for 3000 cycles) with an operating voltage of 1.4 V and a high energy density of 37.3 Wh kg−1 at a power density of 695.6 W kg−1. This work demonstrates a promising strategy using FBC as a substrate for growing LDH materials aiming to achieve high‐performance SCs.
German physicians' expectations of healthcare management companies: An exploratory study
Authors: Oberschachtsiek Dirk , Ehlert Andree
Published: October 2022

Background and aims

Even 20 years after the introduction of managed care (MC) in Germany, many physicians are skeptical of the concept, hindering its acceptance.

Methods

Based on multivariate statistical methods this exploratory study examines how so‐called management companies, that is, administrative service providers within MC contracts, can increase physicians' acceptance of MC by offering, for example, day‐to‐day coordination and administrative tasks.

Results

As a main empirical result, we find support for this hypothesis, that is, that certain physicians evaluate their MC participation according to its prospective administrative support. Based on this, up to four clusters of physicians can be statistically identified in terms of their preferences regarding MC.

Conclusion

As a policy recommendation, we derive from our results that a future focus on the administrative support components of MC is essential to attract certain physician groups to participate in MC.
Depression, anxiety, and performance status among the women with metastatic breast cancer receiving palliative care in Bangladesh: A cross sectional study
Authors: Islam Nashid , Biswas Jheelam , Kowshik Mostofa Monwar , Molla Md Maruf Ahmed , Sarker Mridul , Chowdhury Mostofa Kamal , Bhuiyan AKM Motiur Rahman , Ahmad Nezamuddin
Published: October 2022

Background and Aims

Advanced breast cancer patients suffer from various psychological issues including depression and anxiety. This study aims to explore these psychological issues and their relationship with the performance status.

Methods

This cross‐sectional study was conducted among 95 patients with metastatic breast cancer attending the Department of Palliative Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh from April 2021 to September 2021. Data was collected by face‐to‐face interview using a structured questionnaire along with Hospital Depression and Anxiety Scale. The performance status of the patients was determined by the Eastern Cooperative Oncology Group (ECOG) performance scale. The association between different variables were assessed by χ2 test and Fisher Exact test.

Result

Mean age of the respondents was 48.9 ± 9.9 years. Most of them were married (94.7%), muslim (92.6%) and homemakers (82.1%). More than half (52.6%) of the patients were evaluated having ECOG performance status grade II. Four out of ten  (44.2%) patients had moderate to severely anxiety, and almost one‐third (36.9%) patients were suffering from moderate to severe depression. The patients with high educational status were found to have less depression. In addition, patients faring better on ECOG performance scale (Grade 0 to I) had significantly (p < 0.05) less depression and anxiety.

Conclusion

Depression and anxiety are one of the major psychological sufferings among the women with metastatic breast cancers. All women suffering from breast cancer should be routinely screened and assessed for phychological distress and ensure early intervention.
Identifying unmet information needs of advanced cancer patients in Iran: An in‐depth qualitative study
Authors: Amiri Parasto , Mohammadi Ali , Bahaadinbeigy Kambiz , Kalantari Khandani Behjat , Maazed Vahid
Published: October 2022

Background and Aims

One of the main vital needs for self‐care in patients with advanced cancer is information need. Meeting this need has significant positive effects on improving their treatment and care. This study was conducted to identify the unmet information needs of patients with advanced cancer in Iran.

Methods

This exploratory study was performed from July to February 2021 in the Kerman University of Medical Sciences cancer treatment centers. Oncologists selected eligible patients by purposeful sampling method. Semistructured and in‐depth interviews were conducted with selected patients to collect data. Interviews continued until data saturation. Each interview was audio‐recorded and transcribed verbatim.

Results

In the interviews, 15 patients with advanced cancer ranging in age from 43 to 65 years participated. The most common type of cancer in women was breast (71.4%) and prostate (50%) in men. The two main categories of “types of unmet information needs” and “reasons for not meeting information needs” were extracted from the analysis of patient interviews, with six and four subcategories, respectively.

Conclusion

Cancer patients had a large number of unmet information needs. At the time of identifying the unmet information needs of cancer patients, the basic reasons for not meeting these needs should also be considered because cultural differences and social gaps in societies are inevitable.
Effect of inpatient experiences on patient satisfaction and the willingness to recommend a hospital: The mediating role of patient satisfaction: A cross‐sectional study
Authors: Park Hye Na , Park Do Joong , Han Se Young , Tae Ji Yeon , Jung Keun‐Hwa , Bae Eun Jung , Yoon Ju Young
Published: October 2022

Background and Aims

As high‐quality health care encompasses patient‐centered care, this study used the perceived quality−satisfaction−behavioral intention and structure‐process‐outcome models to (1) investigate the relationships among patient experience, patient satisfaction, and the willingness to recommend a hospital and (2) estimate the indirect effects of patient satisfaction on the relationship between patient experience and the willingness to recommend a hospital.

Methods

A cross‐sectional survey design was adopted to investigate data obtained from the Seoul National University Hospital Patient Experience survey administered in 2020. Responses were analyzed from 1555 patients, who had been admitted to the inpatient ward of a tertiary hospital for a period lasting more than 1 day.

Results

The path model demonstrated a good fit to the relationships between patient experience, patient satisfaction, and the willingness to recommend the hospital. Patient experience directly influenced patient satisfaction (β = 0.659, p < 0.001) and the willingness to recommend the hospital (β = 0.168, p < 0.001), whereas patient satisfaction had an indirect effect (β = 0.418, p < 0.001) on the relationship between patient experience and the willingness to recommend the hospital.

Conclusion

Patient experience is a critical factor that health care systems need to consider for enhancing patient‐centeredness, patient satisfaction, and the willingness to recommend a hospital.
Role of extracellular vesicles in mitochondrial eye diseases
Authors: Anand Sushma , Trounce Ian A. , Gangoda Lahiru
Published: October 2022

Extracellular vesicles (EVs) are small packages that are released by almost all types of cells. While the role of EVs in pathogenesis of certain diseases such as cancer is well established, EVs role in ocular health and disease is still at early stages of investigation. Given the significant role of EVs in pathological development and progression of diseases such as cancer, EVs present a similar opportunity for investigation in ocular pathophysiology. Studies have shown the presence of EVs in fluids from the ocular environment have close links with ocular health and disease. Hence, the cargo carried in EVs from ocular fluids can be used for monitoring disease phenotypes or therapeutic outcomes in eye‐related disorders. Furthermore, in recent times EVs have increasingly gained attention as therapeutics and drug‐delivery vehicles for treatment of eye diseases. There is a close relationship between EVs and mitochondria functioning with mitochondria dysfunction leading to a significant number of ophthalmic disorders. This review discusses the current knowledge of EVs in visual systems with a special focus on eye diseases resulting from dysfunctional mitochondria.
Multiliterate lives: Childhood to adult, lessons learned
Authors: Wood Jeffrey , Peters Emily , Wood Tristan , Wood Simon
Published: October 2022

This retrospective is a group effort between my children and me to make sense of their literacies over the past 26 years. Sharing in the authoring of this retrospective, we take a look back at the ways those literacies unfolded across their childhood. Emily, Tristan, and Simon used different literacies to define who they were and to construct a literate ethos. They each engaged with literacies in powerful and life transforming ways. They used multiple literacies together to help them learn, understand and create meaning more fully. Their stories demonstrate the need for young children to engage with multiple literacies to fully develop as literate adults. This retrospective supports the idea that literacies are complex, motivated, multimodal, semiotic, social, discourse dependent, and imbedded in specific practices.
Development and validation of multiresidue method for organophosphorus pesticides in lanolin using gas chromatography–tandem mass spectrometry
Authors: Gupta Neha , Singh Rakhi , Nayak Sumant Kumar , Das Mukul , Jan Kulsum
Published: October 2022

Lanolin, also known as wool wax, is derived from sheep and has diverse applications in food, cosmetic, textile and lubricant industries. Owing to its direct contact with human, there is a need of studying pesticide residues as contaminants in lanolin. The present study describes a single novel hyphenated gas chromatography–tandem mass spectrometry (GC‐MS/MS) technique for the quantification of 14 organophosphorus (OP) pesticides (tecnazene, propetamphos, diazinon, dichlofenthion, chlorpyrifos methyl, fenchlorphos, malathion, chlorpyrifos, pirimiphos ethyl, bromophos ethyl, tetrachlorvinphos, ethion, phosalone, and coumaphos) in lanolin using electrospray ionization (EI) with multiple reaction monitoring (MRM) acquisition mode. The method is simple in terms of sample preparation steps based on matrix solid‐phase dispersion (MSPD). The method was found to be linear over the analytical range of 0.05–2.0 μg/g, with acceptable coefficient of determination (r2 ≥ 0.99) for all the 14 pesticides. The limit of detection (LOD) and limit of quantification (LOQ) of the method were found to be less than 0.05 and 0.1 μg/g, respectively, for all the 14 OP pesticide residues. The precision and accuracy of the method were found to be within the acceptable limits, that is, recoveries in the range of 83.5%–104.1% with less than 12.5% of relative standard deviation for all the pesticides. The multiresidue method for estimating pesticide residues employing GC‐MS/MS technique will be useful for OP pesticide levels in large number of lanolin samples.
Catheter ablation in patients with atrial fibrillation and heart failure with preserved ejection fraction: A systematic review and meta‐analysis
Authors: Siddiqui Muhammad U. , Junarta Joey , Riley Joshua M. , Ahmed Adnan , Pasha Ahmed K. , Limbrick Kolin , Alvarez Rene J. , Frisch Daniel R.
Published: October 2022

Background

Catheter ablation for atrial fibrillation (AF) is a proven alternative to pharmacologic rhythm control in patients with heart failure with reduced ejection fraction (HFrEF). Whether outcomes differ in patients with heart failure with preserved ejection fraction (HFpEF) is of interest.

Methods

Medline, Scopus, and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies. Primary efficacy outcomes of interest include atrial arrythmia recurrence and repeat ablation. Harm outcomes of interest include all‐cause mortality, all‐cause hospitalizations, cardiovascular hospitalizations, stroke/transient ischemic attack, and cardiac tamponade.

Results

We included 7 observational studies comprising 2554 patients with HFpEF who underwent catheter ablation for AF. When comparing patients with HFpEF versus without HF, there was no significant difference in atrial arrhythmia recurrence (risk ratio [RR] 1.39; 95% confidence interval [CI] 0.91–2.13), stroke or transient ischemic attack (TIA) (RR 0.47; 95% CI 0.03–6.54), or cardiac tamponade (RR 1.20; 95% CI 0.12–12.20). When comparing patients with HFpEF versus HFrEF, there was no significant difference in atrial arrhythmia recurrence (RR 1.12; 95% CI 0.92–1.37), repeat ablation (RR 1.19; 95% CI 0.74–1.93), all‐cause mortality (RR 0.87; 95% CI 0.67–1.13), all‐cause hospitalizations (RR 1.10; 95% CI 0.94–1.30), cardiovascular hospitalizations (RR 0.83; 95% CI 0.69–1.01), stroke or TIA (RR 0.81; 95% CI 0.29–2.25), or cardiac tamponade (RR 0.98; 95% CI 0.19–5.16).

Conclusions

Non‐randomized studies suggest that catheter ablation for AF in patients with HFpEF is associated with similar arrythmia‐free survival and safety profile when compared to patients with HFrEF or without heart failure.
Incidence and development of cholestasis in surgical neonates receiving an intravenous mixed‐oil lipid emulsion
Authors: Yu Lumeng J. , Anez‐Bustillos Lorenzo , Mitchell Paul D. , Ko Victoria H. , Secor Jordan D. , Hurley Alexis P. , Dao Duy T. , Fligor Scott C. , Cho Bennet S. , Tsikis Savas T. , Gura Kathleen M. , Puder Mark
Published: October 2022

Background

Intestinal failure–associated liver disease (IFALD), initially manifesting as cholestasis, is a complication in neonates receiving parenteral nutrition (PN). Soybean oil lipid emulsion (SOLE), though implicated in IFALD, was the only US Food and Drug Administration (FDA)–approved initial intravenous lipid emulsion (ILE) for infants and children in the United States. A mixed‐oil lipid emulsion (MOLE) gained popularity in patients at risk for IFALD and was recently FDA approved as an initial ILE in children. Given the presence of soybean oil in MOLE, we hypothesized that MOLE would not be effective at preventing cholestasis in surgical neonates.

Methods

Neonates with gastrointestinal surgical conditions necessitating PN for ≥14 days and receiving MOLE (SMOFlipid) from July 2016 to July 2019 were analyzed retrospectively. Unpaired and pair‐matched historical surgical neonates treated with SOLE (Intralipid) served as controls. The primary outcome measure was development of cholestasis (direct bilirubin ≥2 mg/dl).

Results

Overall, 63% (10 of 16) of MOLE patients and 22% (30 of 136) of SOLE patients developed cholestasis after ≥14 days of therapy (P = 0.005). The latency to developing cholestasis was significantly shorter in MOLE patients compared with SOLE patients.

Conclusion

In surgical neonates, MOLE may not prevent cholestasis and should not be considered hepatoprotective. Regardless of ILE source, all surgical neonates should be closely monitored for development of IFALD. To date, there is still no ILE able to prevent IFALD.
Fruit growth, carbon allocation, and related enzymes in tomato under different irrigation and potassium application regimes
Authors: Wu Changlong , Zhang Xinsheng , Zhou Chenni , Luo Anrong
Published: October 2022

Background

The increasing concentration of atmospheric CO2 not only affects the growing environment of crops but also aggravates the global greenhouse effect and further aggravates the problem of water shortage. The combined effect of water deficit and potassium (K) application has not been widely studied.

Aims

A pot experiment was conducted to investigate the effect of deficit irrigation (DI) and K application at different growth stages on carbon allocation and enzyme activities related to sugar metabolism.

Methods

Tomatoes were transplanted and planted on April 26, 2017 and harvested on August 15, 2017. Four irrigation regimes were implemented with two water levels (full irrigation‐W and DI‐W/2) in different growth stages, and each water treatment was equally divided into two subgroups: with K (K1) and without K (K0). Fruits from the first to fourth trusses of the tomato plants were sampled. Tomato growth, carbon allocation, and related enzyme activities were measured.

Results

The fresh weight (FW), dry weight, and relative growth rate of dry mass were sensitive to irrigation amount under K fertilization, enhancing the promotion effect of irrigation on fruit. Meanwhile, carbon allocation was sensitive to irrigation amount under K regime. Sucrose synthase (SuSy), acid invertase (AI), and sucrose phosphate synthase (SPS) were also highly sensitive to irrigation amount under K application condition. Starch phosphorylase displayed a quadratic parabola for irrigation amount, and adenosine diphosphate glucose pyrophosphorylase (AGPase) was highly sensitive to irrigation amount without K fertilization. Carbon in the form of other carbohydrates, carbon in the form of soluble sugar (Csol), and fruit water content were the factors that had the greatest influence on the principal components. Classification by K‐means algorithm and canonical correlation analysis showed that FW, fructose, sucrose, and starch could be used as significant indicators of the dry matter components of the fruit for the treatment without K. In the case of K regime, SuSy, AGPase, AI, and Csol could be used as a significant indicator of the correlation analysis of carbon metabolism activity.

Conclusions

The factors related to the improvement of fruit quality and carbon allocation by deficient irrigation and K application were explored. Water stress changed the distribution of photosynthetic carbon between starch and soluble sugar. K application further changed the balance between soluble sugars and other compounds. In particular, it significantly increased the carbon content of soluble sugars and decreased that of other compounds. AI and SuSy are key enzymes affecting carbon metabolism under water‐deficient conditions.
Holocene shore‐level changes, southern Lolland and the Femern Belt, Denmark
Authors: Bennike Ole , Philippsen Bente , Groẞ Daniel , Jessen Catherine
Published: October 2022

We propose a new shore‐level displacement curve for southern Lolland and the Femern Belt in south‐eastern Denmark based on 94 new and four published radiocarbon ages of organic material and shells of marine molluscs. Mires existed in the deeper parts of the Femern Belt during the Early Holocene, and a large lake formed as the water level gradually rose. The lake phase was followed first by a brackish‐water phase from c. 8500 cal a
bp and by a marine phase after c. 7800 cal a
bp when the relative sea level was ~8 m lower than at present. Over the past 6500 years the sea level has gradually risen by ~2 m and reached its highest level in recent times. There are no indications of a higher than present sea level in the area and no indications of 1–2 m sea‐level oscillations as reported from other parts of the region. The relative sea‐level curve for southern Lolland differs from relative sea‐level curves from northern parts of Denmark, which are more influenced by glacio‐isostatic uplift. Southern Lolland has been uplifted by 4–5 m over the last 8000 years, whereas the Limfjord region in northern Denmark has been uplifted by around 12 m during the same period.
Single‐Port Transaxillary Robotic Modified Radical Neck Dissection (STAR‐RND): Initial Experiences
Authors: Ho Joon , Kim Donggyu , Lee Ji‐Eun , Kim Jin Kyong , Lee Cho Rok , Kang Sang‐Wook , Jeong Jong Ju , Nam Kee‐Hyun , Chung Woong Youn
Published: October 2022

Objectives

This study aimed to demonstrate the usefulness of single‐port transaxillary robotic modified radical neck dissection (STAR‐RND) for metastatic thyroid cancer, and its potential to make small and invisible surgical wounds possible compared to open modified radical neck dissection.

Methods

Between January 2020 and July 2021, 30 thyroid cancer patients who underwent lateral neck dissection surgery with the da Vinci SP at Yonsei University Health System (Seoul, Korea) were studied.

Results

All 30 patients, diagnosed with papillary thyroid cancer were women. The average operating time was 293.80 ± 36.58 (min), and the average postoperative hospital stay was 4.77 ± 0.57 (days). All patients were discharged after the expected number of hospitalization days without major complications.

Conclusion

STAR‐RND is technically feasible and safe with a short length of the incision. To our knowledge, this is the first report on the use of a single‐port robotic system for modified radical neck dissection.

Level of Evidence by Using 2011 OCEBM

4 Laryngoscope, 133:709–714, 2023
Clinical and mycological investigations of post‐COVID‐19 acute invasive fungal sinusitis
Authors: Eldsouky Samah Mahmoud , Shahat Amany K. , AL‐Tabbakh AL‐Shaimaa M. , El Rahman Shaymaa M. Abd , Marei Yasmin M. , Mohammed Lina Abdelhady , El‐Shimi Ola Samir , Abdelmotaleb Dina Saad , Marei Yomna Mohammed , Elsayed Mohamed Sabry Abd Elraheam
Published: October 2022

Objectives

An increased incidence of acute invasive fungal sinusitis associated with the recent COVID‐19 pandemic has been observed, which is considered a public health concern. This study aims to detect the incidence, risk factors, causative agents, clinical presentations, outcomes, and susceptibility rate of various antifungals.

Methods

In this cross‐sectional cohort study, a total of 30 patients showing acute invasive fungal rhinosinusitis following a COVID‐19 infection were investigated. Histopathological biopsies, culture identification, and molecular confirmation of the causative agents were conducted. The demographic data, risk factors, clinical presentations, treatment regimen and its outcomes, and efficacy of antifungals were listed and analyzed.

Results

A total of 30 cases with a mean age of 59.6 ± 11.9 years were included. Diabetes mellitus was the most recorded comorbidity with a rate of 86.7%, whereas most of the patients received corticosteroids. The mycological examination confirmed the existence of Mucor (Rhizopus oryzae) and Aspergillus (Aspergillus niger) in 96.7% and 3.3% of the cases, respectively. Various stages of sinonasal involvement (ethmoid, maxillary, sphenoid, and inferior turbinate) represented 100%, 83.3%, 66.7%, and 86.7% of the cases, respectively. Headache and facial pain, ophthalmoplegia, visual loss, and blindness represented 100%, 66.7%, 90%, and 53.3% of the cases, respectively. All the cases were simultaneously treated with surgical debridement and amphotericin B. Moreover, R. oryzae was susceptible to it, whereas A. niger was sensitive to voriconazole, resulting in a survival rate of 86.7% (26/30). The R. oryzae and A. niger isolates were proven to be sensitive to acetic acid, ethyl alcohol, formalin, and isopropyl alcohol.

Conclusions

In patients with COVID‐19, the diagnosis of acute invasive fungal sinusitis and prompt treatment with antifungal medicine and surgical debridement are important in achieving better outcomes and survival rates.

Level of Evidence

4
Boom in mental health support apps creates vexing search for quality
Authors: Enos Gary
Published: October 2022

If any component of the mental health service array deserves the often‐used characterization of a “Wild West,” the booming growth of apps for mental health support certainly qualifies. Just ask any administrator with an active email account in a mental health treatment program who is constantly being pitched the latest technological tool with minimal guidance beyond the marketing.
Culturally, responsive practices for Latino, Hispanic youth
Authors: Canady Valerie A.
Published: October 2022

Mental health stigma and language remain top barriers in service provision for the Latino and Hispanic children and youth population, attendees heard during a recent presentation on innovations in youth mental health hosted by the College for Behavioral Health Leadership (CBHL).
SAMHSA announces winners of Recovery Innovation Challenge
Authors: Canady Valerie A.
Published: October 2022

Identifying innovative practices developed by individuals, or within state systems that advanced recovery in the decade since the Substance Abuse and Mental Health Services Administration (SAMHSA) established its working definition of recovery, was the goal of the agency's first‐ever Recovery Innovation Challenge, officials stated.
Deconvolution closure for mesoscopic continuum models of particle systems
Authors: Panchenko Alexander , Barannyk Lyudmyla L. , Cooper Kevin
Published: October 2022

We present a framework for derivation of closed‐form continuum equations governing mesoscale dynamics of large particle systems. Balance equations for spatial averages such as density, linear momentum, and energy were previously derived by a number of authors. These equations are exact, but are not in closed form because the stress and the heat flux cannot be evaluated without the knowledge of particle positions and velocities. Recently, we proposed a method for approximating exact fluxes by true constitutive equations, that is, using nonlocal operators acting only on the average density and velocity. In the paper, constitutive operators are obtained by using filtered regularization methods from the theory of ill‐posed problems. We also formulate conditions on fluctuation statistics which permit approximating these operators by local equations. The performance of the method is tested numerically using Fermi–Pasta–Ulam particle chains with two different potentials: the classical Lennard–Jones and the purely repulsive potential used in granular materials modeling. The initial conditions incorporate velocity fluctuations on scales that are smaller than the size of the averaging window. Simulation results show good agreement between the exact stress and its closed‐form approximation.
Wong type oscillation criteria for nonlinear impulsive differential equations
Authors: Akgöl Sibel D. , Zafer Agacik
Published: October 2022

We present Wong‐type oscillation criteria for nonlinear impulsive differential equations having discontinuous solutions and involving both negative and positive coefficients. We use a technique that involves the use of a nonprincipal solution of the associated linear homogeneous equation. The existence of principal and nonpricipal solutions was recently obtained by the present authors. As in special cases, we have superlinear and sublinear Emden–Fowler equations under impulse effects. It is shown that the oscillatory behavior may change due to impulses. An example is also given to illustrate the importance of the results.
Congruences for Fourier coefficients of eta‐quotients modulo powers of 5, 7, 11, 13, and 17
Authors: Atmani Sofiane , Bayad Abdelmejid , Hernane Mohand Ouamar
Published: October 2022

In this paper, we investigate the Fourier coefficients of the eta‐quotients of the forms

where
is the Dedekind eta function,
, and 17;
is a positive integer, and
are arbitrary integers. We prove Ramanujan's type congruences for the Fourier coefficients of
modulo powers of prime
. We recover several results due to Atkin, Garvan, Gordon, Wang, Mestrige, and others. We give few examples, and we establish an improvement for Wang's results related to the 11‐regular partition function.
Long time decay of solutions to the 3D incompressible Navier–Stokes equations with nonlinear damping
Authors: Li Hongmin , Xiao Yuelong , Zhao Zhong
Published: October 2022

This paper is interested in the decay of solutions to 3D Navier–Stokes equations with a nonlinear damping term
. We discuss the bounds of the global strong solutions in the negative Sobolev space
and establish the optimal decay rates in
of the global strong solutions. Moreover, the upper bound of the derivative is also obtained. Finally, we investigate the asymptotic stability of the solutions to the system.
Symmetric waves are traveling waves of some shallow water scalar equations
Authors: Khorbatly Bashar
Published: October 2022

Following a straightforward proof for symmetric solutions to be traveling waves by Pei (Exponential decay and symmetry of solitary waves to Degasperis‐Procesi equation.Journal of Differential Equations. 2020;269(10):7730‐7749), we prove that classical symmetric solutions of the highly nonlinear shallow water equation recently derived by Quirchmayr (A new highly nonlinear shallow water wave equation.Journal of Evolution Equations. 2016;16(3):539‐556) are indeed traveling waves, with further information on their steady structures. We also provide a simple proof that symmetric waves are traveling waves to the free surface evolution equation of moderate amplitude waves in shallow water.
Synthetic‐to‐real domain adaptation with deep learning for fitting the intravoxel incoherent motion model of diffusion‐weighted imaging
Authors: Huang Haoyuan , Liu Baoer , Xu Yikai , Zhou Wu
Published: October 2022

Background

Intravoxel incoherent motion (IVIM) is a type of diffusion‐weighted imaging (DWI), and IVIM model parameters (water molecule diffusion rate Dt, pseudo‐diffusion coefficient Dp, and tissue perfusion fraction Fp) have been widely used in the diagnosis and characterization of malignant lesions.

Purpose

This study proposes a deep‐learning model with synthetic‐to‐real domain adaptation to fit the IVIM model parameters of DWI.

Methods

Ninety‐eight consecutive patients diagnosed with hepatocellular carcinoma between January 2017 and September 2020 were included in the study, and routine IVIM–DWI serial examinations were performed using a 3.0 T magnetic resonance imaging system in preoperative MR imaging. The proposed method is mainly composed of two modules: a convolutional neural network–based IVIM model fitting network to map b‐value images to the IVIM parameter maps and a domain discriminator to improve the accuracy of the IVIM parameter maps in the real data. The proposed method was compared with previously reported fitting methods, including the nonlinear least squares (NLSs), IVIM‐NEToptim, and self‐supervised U‐network methods. The IVIM parameter‐fitting performance was assessed by measuring the DWI reconstruction performance and testing the robustness of each method against noise using noise‐corrupted data.

Results

The DWI reconstruction performance demonstrates that the proposed method has better reconstruction accuracy for DWI with a low signal‐to‐noise ratio, which implies that the proposed method improves the fitting accuracy of the IVIM parameters. Noise‐corrupt experiments show that the proposed method is more robust against noise‐corrupted signals. With the proposed method, no outliers were found in Dt, and outliers were reduced for Fp in the abnormal regions (proposed method: 1.85%; NLS: 5.90%; IVIM‐NEToptim: 6.61%; and self‐U‐net: 25.36%). Moreover, experiments show that the proposed method has a more stable parameter estimation performance than the existing methods in the absence of real data.

Conclusions

IVIM parameters can be estimated using a synthetic‐to‐real domain‐adaptation framework with deep learning, and the proposed method outperforms previously reported methods.
A simple Eulerian–Lagrangian weakly compressible smoothed particle hydrodynamics method for fluid flow and heat transfer
Authors: Yoo Hee Sang , Jo Young Beom , Kim Jin Woo , Kim Eung Soo , Choi Tae Soo
Published: October 2022

In this article, we propose a simple, consistent, and robust Eulerian–Lagrangian weakly compressible smoothed particle hydrodynamics (EL‐WCSPH) for the simulation of hydrodynamics and convection heat transfer problems. First, the basic governing equation is formulated using the ALE‐SPH framework. The universal formulation is similar to the standard WCSPH, but the degree of Eulerian and Lagrangian schemes can be controlled by inserting a pre‐defined arbitrary parameter . To alleviate potential numerical errors and inconsistency, particle mass correction is proposed along with particle disorder correction. Then, an algorithm is introduced, in which only a slight modification is necessary compared to the standard WCSPH. Finally, extensive benchmark simulations are conducted to validate the proposed method. As a result, the proposed method is found to perform well in hydrodynamics problems with various flow conditions (pipe flow, lid‐driven problem, Taylor–Green vortex, vortex shedding problem, and water sloshing) and thermal‐hydraulics problems (natural convection in a square cavity).
Computation of eigenvalues of a real, symmetric 3 × 3 matrix with particular reference to the pernicious case of two nearly equal eigenvalues
Authors: Harari Isaac , Albocher Uri
Published: October 2022

Standard, closed‐form solutions for eigenvalues of symmetric, real‐valued matrices are susceptible to loss of significance in floating point computation in the case of two nearly equal eigenvalues. The non‐negative discriminant of the cubic characteristic polynomial vanishes as these two eigenvalues merge. Turning points of the cubic curve reveal two non‐negative invariant factors of the discriminant. These factors are defined in the favorable form of sums of squares by the Cayley–Hamilton theorem, to be used as numerically stable invariants instead of the determinant. Full numerical stability of the procedure is attained by expressing the angular coordinate in terms of the tangent function rather than the cosine, enhanced by range reduction obtained by considering the half angle. This approach combines robust performance in floating point computation with run times that are on par with conventional schemes.
Radiation‐sensitive nanogel‐incorporated Fricke hydrogel dosimeters with reduced diffusion rates
Authors: Wang Kaikai , Zhang Wei , Qi Yameng , Hu Xiaodan , Zhang Xiaohong , Chang Shuquan , Zhang Haiqian
Published: October 2022

Fricke gel dosimeters have great potential for three‐dimensional (3D) dose verification in radiation therapy; however, they suffer from time‐dependent ion diffusion after irradiation, severely affecting their stability and reliability. In this work, a pullulan‐based amphiphilic molecule was synthesized, characterized, and self‐assembled into nanogels. Nanogel structures were embedded into gel dosimeters to reduce the diffusion rates, and radiation‐sensitive nanogel‐incorporated Fricke hydrogel nanocomposites were prepared successfully. The results demonstrated that the diffusion coefficient of improved dosimeters was reduced to 0.125 ± 0.001 mm2 h−1, while maintaining the high optical dose sensitivity (0.0410 ± 0.0004 Gy−1 cm−1). It provides a powerful tool toward the practical application of 3D dosimeters.
“The simple life experiences that every other human gets”: Desire for normalcy among adolescents and young adults with advanced cancer
Authors: Umaretiya Puja J. , Fisher Lauren , Altschuler Andrea , Kushi Lawrence H. , Chao Chun R. , Vega Brenda , Rodrigues Gilda , Josephs Isabel , Brock Katharine E. , Buchanan Susan , Casperson Mallory , Fasciano Karen M. , Kolevska Tatjana , Lakin Joshua R. , Lefebvre Anna , Schwartz Corey M. , Shalman Dov M. , Wall Catherine B. , Wiener Lori , Bona Kira , Mack Jennifer W.
Published: October 2022

Background

Adolescents and young adults (AYAs) with advanced cancer identify normalcy as an important component of quality end‐of‐life care. We sought to define domains of normalcy and identify ways in which clinicians facilitate or hinder normalcy during advanced cancer care.

Procedure

This was a secondary analysis of a qualitative study that aimed to identify priority domains for end‐of‐life care. Content analysis of semi‐structured interviews among AYAs aged 12–39 years with advanced cancer, caregivers, and clinicians was used to evaluate transcripts. Coded excerpts were reviewed to identify themes related to normalcy.

Results

Participants included 23 AYAs with advanced cancer, 28 caregivers, and 29 clinicians. Participants identified five domains of normalcy including relationships, activities, career/school, milestones, and appearance. AYAs and caregivers identified that clinicians facilitate normalcy through exploration of these domains with AYAs, allowing flexibility in care plans, identification of short‐term and long‐term goals across normalcy domains, and recognizing losses of normalcy that occur during cancer care.

Conclusions

AYAs with cancer experience multiple threats to normalcy during advanced cancer care. Clinicians can attend to normalcy and improve AYA quality of life by acknowledging these losses through ongoing discussions on how best to support domains of normalcy and by reinforcing AYA identities beyond a cancer diagnosis.
Role of regional anesthesia in patients with acute sickle cell pain: A scoping review
Authors: Rizvi Munaza B. , Kessler David O. , Rabiner Joni E.
Published: October 2022

Sickle cell disease is the most prevalent inherited blood disorder in the world, with significant morbidity and mortality. Patients often have recurrent painful vaso‐occlusive episodes, and the American Society of Hematology gives a conditional recommendation for the use of regional anesthesia for acute sickle cell pain management. This scoping review summarizes the current evidence and identifies gaps for future research. Our screening process is outlined, and articles that mentioned the use of regional anesthesia for acute sickle cell crises were included. We present and interpret our results and highlight opportunities for future investigation.
A retrospective investigation of the relationship between neuroblastoma response to anti‐GD2 monoclonal antibodies and exposure to opioids for pain management
Authors: Morgan Kyle J. , Dudas Andrew , Furman Wayne L. , McCarville M. Beth , Shulkin Barry L. , Lu Zhaohua , Darji Himani , Anghelescu Doralina L.
Published: October 2022

Objective

Recent increased awareness and research studies reflect possible associations between opioid exposure and cancer outcomes. Children with neuroblastoma (NB) often require opioid treatment for pain. However, associations between tumor response to chemotherapy and opioid exposure have not been investigated in clinical settings.

Methods

This is a single‐institution retrospective review of patients with NB treated between 2013 and 2016. We evaluated opioid consumption quantified in morphine equivalent doses (mg/kg) based on nurse‐ or patient‐controlled analgesia during antibody infusions. We also analyzed their associations with change in primary tumor volume and total tumor burden.

Results

Of 42 patients given opioids for pain related to anti‐disialoganglioside monoclonal antibodies (anti‐GD2 mAb), data completion was achieved for 36, and details of statistical analyses were entered. Median total weight‐based morphine equivalent (over 8 days) was 4.71 mg/kg (interquartile range 3.49–7.96). We found a statistically insignificant weak negative relationship between total weight‐based morphine equivalents and tumor volume ratio (correlation coefficient −.0103, p‐value .9525) and a statistically insignificant weak positive relationship between total weight‐based morphine equivalent and Curie score ratio (correlation coefficient .1096, p‐value .5247).

Conclusion

Our study found no statistically significant correlation between opioid consumption and natural killer (NK) cell‐mediated killing of NB cells as measured by effects on tumor volume/tumor load.
Prenatal diagnosis of fetal ectopia cordis by fetal cardiovascular magnetic resonance imaging
Authors: Liu Ke , Zhu Ming , Dong Su‐Zhen
Published: October 2022

Objective

The purpose of this retrospective study was to report our cases of fetal ectopia cordis (EC) and to evaluate the utility of fetal cardiovascular magnetic resonance imaging (MRI) for the diagnosis of this rare anomaly.

Method

This retrospective study included 11 fetuses with EC. The multiplane steady‐state free precession (SSFP) sequence, single‐shot turbo spin‐echo sequence and non‐gated SSFP cine cardiovascular magnetic resonance were used to evaluate the fetal heart and abdomen.

Results

The 11 fetal cases with EC were examined by fetal cardiovascular MRI and confirmed by postnatal or post‐mortem findings. Of these 11 cases, two were isolated thoracic EC, six had pentalogy of Cantrell, and three had an omphalocele and EC. Among all 11 fetuses, nine were associated with congenital heart defects. In four cases, fetal MRI added additional information compared to fetal ultrasound, however, in two cases, fetal MRI missed the diagnosis of a ventricular septal defect noted by echocardiography.

Conclusion

Fetal MRI combined with prenatal echocardiography can improve the accuracy of the prenatal diagnosis of EC.
Composite films with low dielectric constant and dielectric loss factor at high frequency prepared from polyimide and polytetrafluoroethylene
Authors: Zhang Wang , Jiang Hanzhou , Nie Yong , Fang Xingzhong , Chen Guofei
Published: October 2022

A series of polyimide/polytetrafluoroethylene (PI/PTFE) hybrid films were synthesized by blending water‐soluble polyamide acid salts with water‐based PTFE dispersion and thermal imidization to enhance the dielectric proprieties of PI. The relationship between PTFE filler content and the properties of films has been investigated. The results showed that the dielectric properties of PI were effectively improved by PTFE fillers and all films showed excellent heat resistance. When the addition of PTFE filler was 30 wt%, the PI and PTFE in PI/PTFE‐30 hybrid film still showed good compatibility and dispersity. The dielectric constant and dielectric loss factor were decreased to 2.42 and 0.0044 at 10 GHz, respectively. Meanwhile, the film PI/PTFE‐30 had the lowest water absorption (0.11%) and maximum water contact angle (95.3°).
Aromaticity of the triplet states of corannulene and coronene
Authors: Govorov Dmitrii , Pitawela Niroodha R. , Gudmundsdottir Anna D.
Published: October 2022

Sunlight‐driven photochemical reactions are an important tool for sustainable organic synthesis. However, compared with ground states, for which the effects of structure on properties and reactivity are well established, the understanding of excited states is limited. In particular, an improved understanding of aromaticity and antiaromaticity in excited states is necessary to develop strategic photochemical methods for synthesizing polycyclic aromatic compounds. Herein, using density functional theory (DFT)‐optimized structures, the ground singlet (S0) and lowest triplet (T1) states of coronene and corannulene were compared. Bond length analysis demonstrated that both triplet corannulene and triplet coronene bear a partial resemblance to benzene. Nucleus‐independent chemical shift (NICS(0), NICS(1.7)ZZ, NICS scans) and anisotropy of the induced current density (ACID) calculations were carried out to compare the induced magnetic currents in these molecules. This analysis demonstrated rather weak π‐conjugation and partial antiaromaticity in the S0 state of each molecule. In contrast, a combination of circular induced currents and pronounced antiaromaticity was found in the T1 state of each molecule. However, the T1 of corannulene exhibited higher stability, which should facilitate functionalization. Consequently, corannulene is considered more suitable for photochemical applications.
Quality of life of long‐term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls
Authors: Chantziara Sofia , Musoro Jammbe , Rowsell Alison C. , Sleurs Charlotte , Coens Corneel , Pe Madeline , Suciu Stefan , Kicinski Michal , Missotten Pierre , Vandecruys Els , Uyttebroeck Anne , Dresse Marie‐Françoise , Pluchart Claire , Ferster Alina , Freycon Claire , Bosch Jutte Van Der Werff ten , Rohrlich Pierre , Benoit Yves , Darlington Anne‐Sophie , Piette Caroline ,   European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG)
Published: October 2022

Objective

Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long‐term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long‐term QoL outcomes of survivors of childhood ALL compared to matched population controls.

Methods

QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF‐12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF‐12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.

Results

One hundred and eighty‐six survivors (mean age: 27.6 years; range: 18.1–52.8) at follow‐up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self‐esteem, Nutrition and Paid Work.

Conclusions

Our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.