bluuebunny/crossref_metadata_2025 huggingface dataset:
Новые тенденции в подготовке кадров по «умному хранению» в сфере логистики
Authors: И. Цао , Ян. Чжан , С. Вэй
Published: October 2024

в статье рассматривается актуальная тема подготовки кадров в сфере логистики с помощью инновационных технологий «умного хранения». Искусственный интеллект в сфере Интернета вещей (IoT) активно применяется в современных логических цепочках: от поставок до размещения на складских площадях. Логические решения с помощью искусственного интеллекта позволяют существенно сократить время и ресурсы для поставщика и продавца в современных условиях цифровых сделок. Методология исследования основана на системном подходе и включает в себя группу специальных методов (синтез, анализ, сопоставление, систематизация), а также ряд специальных методов: историографический анализ научной литературы по изучаемой теме; формально-логический метод и систематизация результатов. По итогу проведенного исследования автор статьи пришел к следующему выводу: в современных условиях подготовка специальных кадров (логистов) должна быть реализована с помощью новых технологий, поскольку инновационные решения в данной области особенно социально востребованны.

the article discusses the topical topic of training personnel in the field of logistics using innovative technologies of «smart storage». Artificial intelligence in the field of the Internet of Things (IoT) is actively used in modern logical chains: from supply to placement in warehouse areas. Logical solutions using artificial intelligence can significantly reduce the time and resources for the supplier and seller in modern conditions of digital transactions. The research methodology is based on a systematic approach and includes a group of special methods (synthesis, analysis, comparison, systematization), as well as a number of special methods: historiographical analysis of scientific literature on the topic under study; formal-logical method and systematization of results. Based on the results of the study, the author came to the following conclusion: in modern conditions, the training of special personnel (logisticians) should be implemented with the help of new technologies, since innovative solutions in this area are especially socially in demand.
Взаимосвязь личностных особенностей с психологическим благополучием женщин, регулярно посещающими фитнес-центр
Authors: Н.Д. Мальцева
Published: October 2024

целью данной статьи является установление взаимосвязей между личностными особенностями и психологическим благополучием женщин разного возраста, регулярно посещающих фитнес-центр. Методы: Выборка исследования составила 60 человек: 30 женщин в возрасте 27-35 лет и 30 женщин в возрасте 36-47 лет. Использовались Шкала психологического благополучия К. Рифф, Тест Р. Кеттелла, 16PF, форма C, Многомерная шкала перфекционизма, MPS П. Хьюлита и Г. Флетта, Тест эмоционального интеллекта К. Холла. Статистическая обработка подразумевала использование коэффициента корреляции Спирмена. Результаты: Обнаружено, что такие черты, как общительность, эмоциональная стабильность, уравновешенность, низкая тревожность и подозрительность, развитый эмоциональный интеллект и низкий уровень социально-предписанного перфекционизма связаны с повышением психологического благополучия женщин, вне зависимости от возраста. Выводы: Существуют универсальные, не связанные с возрастом личностные черты женщин, которые коррелируют с повышением их психологического благополучия, и которые необходимо учитывать при организации психологического сопровождения физических тренировок в фитнес-центре.

the purpose of this article is to establish the relationship between personal characteristics and psychological well-being of women of different ages who regularly attend a fitness center. Methods: The study sample consisted of 60 people: 30 women aged 27-35 years and 30 women aged 36-47 years. The K. Riff Scale of psychological well-being, the R. Kettell Test, 16PF, Form C, the Multidimensional Perfectionism Scale, P. Hewlitt and G. Flett MPS, and the K. Hall Emotional Intelligence Test were used. Statistical processing implied the use of Spearman's correlation coefficient. Results: It was found that traits such as sociability, emotional stability, balance, low anxiety and suspicion, developed emotional intelligence and a low level of socially prescribed perfectionism are associated with increased psychological well-being of women, regardless of age. Conclusions: There are universal, age-unrelated personality traits of women that correlate with an increase in their psychological well-being, and which must be taken into account when organizing psychological support for physical training in a fitness center.
Методики технической подготовки юношей, занимающихся лыжероллерным спортом
Authors: В.А. Писоцкий
Published: October 2024

в статье отражены результаты теоретического анализа, призванного обобщить имеющиеся на сегодняшний день сведения о применяемых в практике организации тренировочного процесса спортсменов-лыжероллеров методик повышения их технического мастерства. Результаты, полученные по окончании анализа, позволяют свидетельствовать о многообразии методик организации спортивной подготовки спортсменов, эффективность которых в большей степени обусловлена соблюдением определенных соотношений, варьируемых в условиях большого разнообразия индивидуальных особенностей лыжероллера и специфических характеристик соревновательной деятельности. Подобная многофакторность, предоставляющая широкий спектр действенных с точки зрения соревновательных достижений инструментов, может быть использована с максимальной эффективностью в случае выработки стратегии управления, которое возможно в случае применения метода моделирования исследуемого процесса. Таким образом, достигнутые результаты свидетельствуют о необходимости включения разнообразных методик повышения технической подготовленности спортсмена-лыжероллера при условии оптимального их моделирования в контексте конкретного этапа и периода спортивной подготовки.

the article reflects the results of a theoretical analysis designed to summarize the information available to date on the methods used in the practice of organizing the training process of roller skiers to improve their technical skills. The results obtained at the end of the analysis allow us to testify to the variety of methods of organizing sports training of athletes, the effectiveness of which is largely due to compliance with certain ratios, varying in conditions of a wide variety of individual characteristics of a roller skier and specific characteristics of competitive activity. Such a multifactorial approach, which provides a wide range of tools that are effective from the point of view of competitive achievements, can be used with maximum efficiency in the case of developing a management strategy, which is possible if the modeling method of the process under study is applied. Thus, the achieved results indicate the need to include a variety of techniques to improve the technical fitness of a roller skier, provided that they are optimally modeled in the context of a specific stage and period of sports training.
Подходы к подготовке баскетболистов студентов технического профиля
Authors: М.А. Комлев , К.И. Гвоздева , Е.В. Черкасова , Д.А. Потапов
Published: October 2024

уровень физической, психологической и тактической подготовленности баскетболистов обеспечивает эффективность игровой деятельности. Поэтому, вопросы повышения уровня подготовленности баскетболистов являются актуальными. Проблематика исследования заключается в необходимости обеспечения высокой подготовленности баскетболистов студентов технических вузов с учетом исходно низкого уровня физической подготовленности. В ходе исследования решались ряд задач: ¾ анализ уровня физической, тактической подготовленности баскетболистов студентов; ¾ определение направлений в подготовке баскетболистов; Полученные в ходе исследования результаты имеют практическое значение и могут быть использованы при организации учебно-тренировочного процесса с баскетболистами, а также при организации учебного процесса по элективным дисциплинам по физической культуре в учебных заведениях.

the level of physical, psychological and tactical preparedness of basketball players ensures the effectiveness of playing activities. Therefore, the issues of improving the level of preparedness of basketball players are relevant. The problem of the study is the need to ensure high fitness of basketball players of students of technical universities, taking into account the initially low level of physical fitness. During the research, a number of tasks were solved: ¾ analysis of the level of physical and tactical preparedness of students' basketball players; ¾ determining the directions in the training of basketball players; The results obtained in the course of the study are of practical importance and can be used in organizing the educational and training process with basketball players, as well as in organizing the educational process in elective disciplines of physical culture in educational institutions.
Поддержка условий преподавания музыкальной эстетики в современных университетах
Authors: И. Лянь
Published: October 2024

статья посвящена актуальной проблеме поддержки условий преподавания музыкальной эстетики в рамках системы высшего образования. Цель статьи заключается в рассмотрении преподавания музыкальной эстетики в процессе преподавания в университете. Задачи исследования заключались в выявлении основных педагогических условий преподавания музыкальной эстетики в современных вузах с точки зрения поддержки наиболее эффективных из них. В основе методологии исследования лежат системный и психолого-педагогический подход. В работе над статьей были использованы методы общенаучного спектра: формально-логический метод, описательный анализ, метод научной систематизации и сопоставления. К числу специальных методов относятся историографический анализ научного дискурса изучаемой темы; метод качественного анализа, метод невключенного педагогического наблюдения. По итогу проведенного исследования автор статьи пришел к следующим выводам: в рамках поддержки педагогических условий преподавания музыки в университете необходимо реализовать три вида поддержки (административная, техническая и психолого-педагогическая). Все три вида поддержки должны быть реализованы одновременно, в течение всего процесса обучения музыке в университете.

the article reveals a current problem of supporting the conditions for teaching musical aesthetics within the framework of the higher education system. The research goal is to consider the teaching of musical aesthetics in the process of teaching at the university. The research objectives were to identify the main pedagogical conditions for teaching musical aesthetics in modern universities from the point of view of supporting the most effective of them. psychological and pedagogical approach. In the work on the article, the methods of the general scientific spectrum were used: the formal-logical method, descriptive analysis, the method of scientific systematization and comparison. Special methods include historiographical analysis of the scientific discourse of the topic under study; the method of qualitative analysis, the method of non-involved pedagogical observation. Based on the study results, the author concluded that, within the framework of supporting the pedagogical conditions for teaching music at the university, it is necessary to implement three types of support (administrative, technical and psychological-pedagogical). All three types of support must be implemented simultaneously, during the entire process of studying music at the university.
Косвенные речевые признаки при диагностике суицидальной направленности текстовых сообщений в социальных сетях
Authors: М.В. Шпорт , А.В. Прохоров
Published: October 2024

в статье рассматривается вопрос диагностики суицидального поведения пользователей социальных сетей путем анализа их постов и сообщений, находящихся в открытом доступе. Изучено влияние косвенных текстовых признаков в определении суицидальной направленности высказывания. В проведенном исследовании удалось установить, что лица с суицидальным и депрессивным поведением в своих текстах чаще используют местоимения и частицы, например «Я» или «Не». Учет частоты слов «Я», «Не», местоимений времени и притяжательных местоимений может служить дополнительным маркером диагностики суицидальной направленности текста. Проведенное исследование показывает, что большое количество указанных слов может являться показателем сложного психоэмоционального состояния. Результаты исследования показывают, что непрямые текстовые признаки в высказываниях могут служить дополнительным инструментом их суицидальной направленности и вместе с другими инструментами повысить точность диагностики возможности суицида у пользователей социальных сетей.

the article deals with the diagnosing suicidal behaviour of social net-work users by analyzing their posts and messages in the public domain. The influence of indirect textual features on determining the suicidal bias of an ut-terance was investigated. The study revealed that people with suicidal and depressive behaviour use pronouns and particles, for example, ‘I’ or ‘not’, more often in their texts. Taking into account the frequency of the words ‘I’ and ‘not’, pronouns of time and possessive pronouns can serve as an additional marker for diagnosing the suicidal bias of texts. The study shows that a large number of these words can be an indicator of a complex psycho-emotional state. The research results show that indirect textual features can serve as an extra tool for their suicidal bias and, together with other tools, increase the accuracy of diagnosing the possibility of suicide in social network users.
Роль саморегуляции в профессиональной самореализации личности
Authors: С.Ю. Фролов
Published: October 2024

в настоящей научной работе автор кратко анализирует особенности роли саморегуляционных процессов в профессиональной самореализации личности. Для этого автор исследует, прежде всего, сущность самой по себе саморегуляции, отмечает ее характерные особенности, далее акцентирует внимание уже на ее особой значимости в контексте именно профессиональной самореализации. Результаты: Научная новизна данного научного исследования заключается в подготовке комплексного исследования, формировании авторских выводов относительно особенностей роли саморегуляционных процессов в профессиональной самореализации личности. Данная научная статья будет полезна теоретикам, практикам, обучающимся и профессорско-преподавательскому составу экономических и иных направлений подготовки, а также широкому кругу читателей, интересующихся проблемами и перспективами развития роли саморегуляционных процессов в профессиональной самореализации личности в целом. Заключение. В заключение исследования автор также пишет об универсальном, комплексном и системном свойстве данной компетенции, а также о необходимости ее постоянного совершенствования и развития. Кроме того, автор делает вывод о том, что далеко не каждая личность обладает способностью довести данную компетенцию до высокого уровня развития – это актуально только для комплексно, полноценно развитой личности.

in this scientific work, the author briefly analyzes the features of the role of self-regulatory processes in the professional self-realization of an individual. To do this, the author examines, first of all, the essence of self-regulation itself, notes its characteristic features, and then focuses on its special significance in the context of professional self-realization. Results: The scientific novelty of this scientific study lies in the preparation of a comprehensive study, the formation of the author's conclusions regarding the features of the role of self-regulatory processes in the professional self-realization of an individual. This scientific article will be useful to theorists, practitioners, students and faculty of economic and other areas of training, as well as a wide range of readers interested in the problems and prospects for the development of the role of self-regulatory processes in the professional self-realization of an individual in general. Conclusion. In conclusion of the study, the author also writes about the universal, complex and systemic property of this competence, as well as the need for its constant improvement and development. In addition, the author concludes that not every person has the ability to bring this competence to a high level of development - this is relevant only for a comprehensively, fully developed personality.
Тактические особенности развития стрелковой техники с уклоном на многоповторную цикличность
Authors: О.Н. Кузнецов
Published: October 2024

в тематике представленной работы, проведен анализ эффективного воздействия циклического подхода во время подготовки лиц рядового и младшего начальствующего состава, впервые пребывающих на обучение в образовательные организации МВД России. На начальном этапе обучения затронуты технические связки двигательных действий с оружием и без оружия. Определена положительная динамика в развитии устойчивых положений во время осуществления прицеливания, что может сопутствовать благоприятному решению поставленной задачи и ее безошибочному выполнению во время стрельбы. Установлены и приняты к использованию, различные техники переходов от простого к более сложному этапу разучивания упражнений. Приведен ряд примеров сочетающих в себе наглядность и доступность использования их в служебной деятельности. Полученные результаты, подробно разъяснены и апробированы в процессе обучения с их рекомендательными пояснениями. Обоснована и доказана теория, которая за непродолжительное время направлена на формирование долгосрочного и устойчивого двигательного навыка в ограниченный промежуток времени. Успешно реализована попытка, воздействия на адаптивное закрепление мышечного восприятия и формирования у обучающихся чувства временного ритма в процессе движения с выходом на цель.

the subject of the presented work is an analysis of the effective impact of the cyclic approach during the training of privates and junior officers arriving for the first time to study at educational institutions of the Ministry of Internal Affairs of Russia. At the initial stage of training, technical connections of motor actions with and without weapons are affected. Positive dynamics in the development of stable positions during aiming are determined, which can accompany a favorable solution to the task and its error-free execution during shooting. Various techniques for transitions from a simple to a more complex stage of learning exercises are established and accepted for use. A number of examples are given that combine clarity and accessibility of their use in official activities. The results obtained are explained in detail and tested in the training process with their recommended explanations. The theory is substantiated and proven, which in a short time is aimed at the formation of a long-term and sustainable motor skill in a limited period of time. An attempt to influence the adaptive consolidation of muscle perception and the formation of a sense of time rhythm in those involved in the process of movement towards the target has been successfully implemented.
Применение игрового метода в обучении волейболу для улучшения организации учебного процесса по прикладной физической культуре
Authors: А.Н. Созонова , В.А. Ластовляк , Т.С. Кланюк , Е.Д. Роменко
Published: October 2024

игровой метод является системой педагогических подходов, которые основаны на использовании игры как средства обучения волейболу. Благодаря игровым элементам в процессе обучения волейболу у студентов формируется положительная эмоциональная установка на занятия, развивается мотивация и интерес к физической активности. Соревновательный метод стимулирует у обучающихся стремление к самосовершенствованию и достижению лучших результатов в игре. Весомую роль имеет правильная организация игровой и соревновательной деятельности. Преподаватель обязан учитывать физические способности и индивидуальные особенности каждого студента, подбирая соответствующие виды игр и соревнований. Эффективная организация занятий по волейболу подразумевает чередование различных видов двигательной активности, использование новых заданий и упражнений, а также поощрение личных достижений студенческой молодежи. Внедрение игровых методов в процесс обучения по волейболу помогает не только улучшить физическую подготовку обучающихся, но и формирует важные социально-личностные навыки. Это направление развития физической культуры отвечает современным требованиям общества и образовательной системы, которое направленно на всестороннее развитие современной молодежи.

the game method is a system of pedagogical approaches based on the use of the game as a means of teaching volleyball. Thanks to the game elements in the process of learning volleyball, students form a positive emotional attitude to classes, develop motivation and interest in physical activity. The competitive method encourages students to strive for self-improvement and achieve better results in the game. Proper organization of gaming and competitive activities plays a significant role. The teacher is obliged to take into account the physical abilities and individual characteristics of each student, choosing the appropriate types of games and competitions. Effective organization of volleyball classes involves alternating different types of physical activity, the use of new tasks and exercises, as well as encouraging personal achievements of students. The introduction of game methods into the volleyball training process helps not only to improve the physical fitness of students, but also forms important social and personal skills. This area of physical education development meets the modern requirements of society and the educational system, which is aimed at the comprehensive development of modern youth.
SOME PROBLEMS OF ECOLOGICAL CONSTRUCTION AND POSSIBLE SOLUTIONS
Authors: Ада Георгиевна Тибилова , Ванда Состиковна Кодоева , Светлана Роландовна Котолова
Published: October 2024

В статье рассмотрены основные экологические проблемы, в строительной индустрии. Актуальность темы обусловлена увеличением объемов работ в строительной отрасли и возрастанием негативного влияния строительства на окружающую среду. Авторами статьи предложены пути предотвращения этого отрицательного воздействия путем реализации ряда экологических решений.

The article discusses the main environmental issues in the construction industry. The relevance of the topic is due to the increase in the volume of work in the construction industry and the increase in the negative impact of construction on the environment. The authors of the article propose ways to prevent this negative impact by implementing a number of environmental solutions.
Implementasi Tri Hita Karana (THK) pada Kearifan Lokal Lombok Maulid Adat di Desa Lendang Nangka
Authors: Zahara Laxmi , Mujiburrahman  , Mahsup Mahsup , Sutajaya I Made , Suja I Wayan , Astawa Ida Bagus Made
Published: October 2024

Penelitian ini bertujuan untuk mengkaji implementasi konsep Tri Hita Karana (THK) pada kearifan lokal masyarakat Desa Lendang Nangka melalui acara Maulid Adat sebuah tradisi penghormatan atas kelahiran Nabi Muhammad SAW dan sumber mata air desa yang terdiri dari serangkaian acara termasuk di dalamnya acara selametan Otak Aik dan Pandik Keris.  Ritual ini juga mencakup kegiatan keagamaan, seperti zikir dan pembacaan kitab, serta simbolis bubur yang melambangkan asal-usul manusia. Tradisi ini diikuti oleh masyarakat lokal dan sekitarnya, termasuk kelompok pertanian yang menggunakan air sebagai irigasi. Filosofi acara ini mengandung tiga konsep utama: kehendak, Nur Muhammad, dan Zat Adam, yang melambangkan hubungan antara roh dan jasad manusia serta pentingnya menjaga alam. Melalui metode pengumpulan data dengan wawancara dan angket, penelitian ini menemukan bahwa konsep Tri Hita Karana yang meliputi hubungan harmonis antara manusia dengan Tuhan (Parahyangan), manusia dengan sesama (Pawongan), dan manusia dengan alam (Palemahan) terintegrasi dalam kehidupan masyarakat. Tradisi ini memperkuat nilai-nilai sosial dan ekologis di Desa Lendang Nangka.
Implikasi Sorong Serah Aji Krame dalam Mempererat Hubungan Keluarga di Masyarakat Sasak
Authors: Sukroyanti Baiq Azmi , Sutajaya I Made , Suja I Wayan , Astawa Ida Bagus Made
Published: October 2024

This study examines the cultural significance of the Sorong Serah Aji Krame tradition, a Sasak traditional wedding ritual on Lombok Island, Indonesia. This tradition not only represents the transfer of material goods, but also serves as a mechanism to strengthen family cohesion. Through qualitative methods, including in-depth interviews and observations, this study explores how this ritual builds emotional connections, honors elders, and ensures continuity between generations in the Sasak community. The results show that Sorong Serah Aji Krame plays an important role in maintaining social harmony and family solidarity, especially amidst the challenges of modernization.
Oral cancer perceptions amongst adult attendees of a Dental Hospital in the Republic of Ireland: A cross-sectional pilot study
Authors: Anishchuk Sviatlana , Galvin Sheila , Moran Gary , Healy Claire M
Published: October 2024

Objectives

This study aimed to assess (i) awareness of the signs and symptoms of oral cancer and its risk factors and (ii) awareness and attitudes towards oral cancer screening, in an Irish cohort.

Methods

A cross-sectional self-administered survey was used in a convenience sample of patients > 18 years with no cancer history attending the Dublin Dental University Hospital. The data were analysed using descriptive statistics, Pearson’s Chi-squared and Fisher’s exact tests.

Results

124 responses were received. 83.7% reported knowing little/nothing about oral cancer risk factors. 12.8% did not identify smoking, 35.3% alcohol consumption, 90.5% betel nut, 35.3% age and 80.2% male gender, as risk factors. 46% were unaware that a dentist is trained to check for oral cancer. Participants were more likely to seek advice regarding a persistent oral white or red patch from their doctor than their dentist but were more likely to attend their dentist in relation to a persistent ulcer, swelling or pain. The study did not find any statistically significant relationship between gender, age, educational level and either awareness of the signs and symptoms of oral cancer and its risk factors, or with experiences and attitudes towards oral cancer screening.

Conclusions

The study demonstrated a lack of knowledge of the risk factors, signs and symptoms of oral cancer, and of awareness of the role of dentists in screening for oral cancer. It should be repeated in a larger cohort in non-dental settings to inform the development of oral cancer awareness programmes that address those areas where awareness is lacking.
Epidemiology and Clinical Challenges in Early Diagnosis of Penis Cancer in Developing Countries
Authors: Perdana I Gede Sukma Okta
Published: October 2024

Penile cancer, though rare globally, has a higher incidence in several developing countries due to factors such as human papillomavirus (HPV) infection, poor hygiene, and certain cultural practices. This study aimed to improve early detection and treatment of penile cancer in developing countries, reduce the burden of disease, and develop strategies for raising education and awareness in these regions. The research method used was descriptive with a qualitative approach. Data collection was carried out using documentation techniques, and analysis was conducted using triangulation. The research has significant implications for public health policy and medical education in developing countries. The findings emphasize the importance of creating culturally sensitive health campaigns and improving access to early diagnostic tools, which could ultimately lead to earlier detection and improved patient outcomes.
Dermal Acute Toxicity Test
Authors: Meza Meizora Aripima , Hermawati Ema
Published: October 2024

The aim of the dermal acute toxicity test is to identify the intrinsic toxicity of a product by assessing its hazard potential following acute skin exposure. This test also provides preliminary data that can be used to determine the appropriate dosage level and guide the design of subsequent toxicity studies, including determining the LD50 value and information about skin absorption. In this study, female rats (Rattus Nervegicus) are used as test subjects. The test material is prepared by diluting 15 ml of the sample to a final concentration of 994.9 mg/mL. The rats are exposed to the material for 24 hours. Post-exposure, microanatomical observations, and surgery in the abdominal and thoracic areas revealed no abnormalities.
The Relationship Between Chemotherapy Management and Quality of Life in Breast Cancer Patients in Yogyakarta
Authors: Marisca Stephanie , Christian Michael
Published: October 2024

Breast cancer, one of the most prevalent cancers in women, has a high mortality rate. Chemotherapy is commonly used to stop cancer growth, but it significantly affects patients' quality of life. While several studies have reported on the impact of adjuvant chemotherapy on the quality of life in breast cancer patients aged 20-80 with grades 1-4, limited research focuses on grade 2-3 patients aged 40-50, as measured by the QLQ C-30. Using random consecutive sampling, this study investigates the relationship between chemotherapy and quality of life in grade 2-3 breast cancer patients aged 40-50 in Yogyakarta. Quality of life is assessed through the QLQ C-30 questionnaire, with data analyzed by the unpaired t-test method at a 95% confidence level (p < 0.05). Results show a significant decrease in the overall quality of life (p = 0.000) but no significant differences in function (p = 0.152) and symptom scales (p = 0.15). Respondents not undergoing chemotherapy reported a better general quality of life than those receiving treatment.
First-line Treatment Selection for Advanced Hepatocellular Carcinoma
Authors: Al Maqrashi Zainab , Meyers Brandon M.
Published: October 2024

The treatment landscape of advanced/unresectable hepatocellular carcinoma (uHCC) has rapidly evolved since 2018. Over recent years, various systemic therapies and treatment approaches have been explored. Systemic therapy has primarily relied on tyrosine kinase inhibitors (TKIs); however, immune checkpoint inhibitors (ICIs) have more recently entered the realm of the treatment armamentarium.
Prostate-specific Membrane Antigen (PSMA): A Diagnostic and Therapeutic Target in Advanced Prostate Cancer
Authors: Emmenegger Urban , Sperandio Rubens
Published: October 2024

Prostate cancer is among the most prevalent malignant conditions globally, and both incidence and mortality are expected to increase markedly over the next two decades. Recently, the diagnostic and treatment landscape for managing this disease underwent remarkable advances that led to the incorporation of innovative approaches, such as prostate-specific membrane antigen (PSMA) theranostics.
PSMA, which is also known as folate hydroxylase or glutamate carboxypeptidase, is a transmembrane protein 100- to 1000-fold overexpressed by prostate cancer cells compared to healthy cells found in the benign prostate gland, salivary glands, proximal renal tubules, small intestine mucosa, and hepatocytes, amongst others.
Since its discovery over 30 years ago (see Figure 1 for this and other milestones), PSMA has caught the attention of the scientific community as a potential therapeutic target, and for the past two decades many efforts have been undertaken to identify and develop PSMA ligands and antibodies that could be exploited as prostate cancer therapeutics.
This review aims to provide an overview of available PSMA ligands, their mechanisms of action, diagnostic and therapeutic applications, and future perspectives of PSMA-targeted therapeutic approaches within the field of radioligand therapy (RLT).
AİLE SAĞLIĞI MERKEZİNE KAYITLI 65 YAŞ ÜSTÜ HASTALARDA İLAÇ UYUMUNUN TİME KRİTERLERİNE GÖRE DEĞERLENDİRİLMESİ
Authors: Ulusan Cemil , Gültekin Ulusan Ayça , Mercan Başpınar Melike , Basat Okcan
Published: October 2024

AMAÇ: Amacımız polikliniğinimize başvuran 65 yaş ve üstü hastaların başvuru sırasında kullanmakta oldukları ilaçları Türkiye’ye özgü yaşlıda ilaç kullanım kriterlerini ölçen TİME kriterleri ile karşılaştırmaktır.
GEREÇ ve YÖNTEM: Bu çalışmada İstanbul Gaziosmanpaşa Duygu Özyurt Aile Sağlığı Merkezi 34.21.068 No'lu ' birime kayıtlı 65 yaş ve üzeri 129 hastaya yüz yüze görüşme methodu ile sosyodemografik özellikleri ve tıbbi öyküyü içeren anket uygulandı . Çalışma verileri değerlendirilirken tanımlayıcı istatistiksel metodların yanısıra niceliksel verilerin karşılaştırılmasında Mann Whitney U testi, niteliksel verilerin karşılaştırılmasında ise Ki-Kare testi, Fisher’s Exact Ki-Kare testi, Fisher Freeman Halton Testi ve Continuity (Yates) Düzeltmesi kullanıldı.
BULGULAR: Yaşları 65 ile 89 arasında değişmekte olan Kayıtlı 129 hastanın %41,1 i erkek ;%58,9 u kadındı.Yaş ortalaması 71.89±5.22, %75.2’si evli, . %55.8’i emekli ve sadece , %0.8’i yüksekokul/üniversite mezunudur.Kronik hastalık ortalaması 4.11±2.10 du.Kullanılan ilaç sayısı ortalaması 7.67±3.16 idi.Olguların %89.9’unda polifarmasi, %31.8’inde çoklu polifarmasi mevcuttu.Time to Stop kriterlerine göre herhangi bir sistemde toplam uygunsuz ilaç kullanımı görülme oranı %84.5’tir.Time to Start kriterlerine göre herhangi bir sistemde toplam uygunsuz ilaç kullanımı görülme oranı %100’dür.
SONUÇ: Ülkemizdeki ilaç reçeteleme pratiği farklılıkları ve ülkemiz ilaç pazarındaki farklılıklar nedeniyle Türkiye’ye uygun hale getirilmiş TİME kriterleri, en son veriler ve yerel uygulamalar dikkate alınarak oluşturulmuş ve uygulanmaya başlanmıştır.Hastalarımızın ilaçlarının uygunluğunu değerlendirme konusunda büyük kolaylık sağlayacaktır
Beslenme ve Yeme Bozukluklarında Dermatolojik Belirtiler: Geleneksel bir Derleme
Authors: Çubukçu Çağla , Hocaoğlu Çiçek
Published: October 2024

Beslenme ve yeme bozuklukları deri belirtileri olan psikiyatrik bozukluklardır. Erken tanı için deri belirtileri yönlendirici olabilir. Bu belirtiler beslenme yetersizliğine, eşlik eden fiziksel ve psikiyatrik eş tanılara, laksatif, diüretik, emetik ilaç kullanımına bağlı ortaya çıkabilir. Tüm yeme bozukluklarında en sık görülen deri bulgusu kserozistir. Yeme bozukluğu olan hastaların %90’dan fazlasını kadın hastalar oluşturmaktadır. Anoreksiya nervoza (AN) ve bulimiya nervozanın (BN) başlangıç yaşı ergenlik ve genç erişkinlik dönemidir. Akne vulgaris gibi bu döneme özgü dermatolojik hastalıklarla yeme bozuklukları arasındaki ilişkiyi açıklamak güçtür. Dermatolojik belirtinin şiddeti, yeme bozukluğunun prognozu hakkında bilgi verici olabilir. Yeme bozukluğunun tedavisi ile dermatolojik belirtiler de ortadan kalkabilir. Bulimiya nervozada deri belirtileri AN ile benzer olup, bu belirtiler sıklıkla kserozis, akne, alopesi, diş çürükleri, hipertrikozis ve Russell belirtisidir. Bu belirti kendi kendine kusturmanın patognomonik bulgusudur ve BN’da yaygındır. Yeme bozukluğu hastasının el muayenesi kserozis, akrosiyanoz, karotenoderma, Russell belirtisi, artefakt dermatiti gibi pek çok ipucu sunabilir. Pika hastalığında demir, çinko gibi eser elementlerin eksikliğine bağlı deri belirtileri görülebilir. Diş etlerinde kurşun intoksikasyonuna bağlı Burton çizgilenmeleri meydana gelebilir. Tıkınırcasına yeme bozukluğunda obezitenin deri belirtilerine rastlanır. Yeme bozuklukları dermatologlar ve psikiyatrlar tarafından multidisipliner bir yaklaşımla ele alınmalıdır. Bu sayede hastalıklarını inkar etme eğiliminde olan yeme bozukluğu olguları için erken tanı ve tedavi şansı doğabilir. Altta yatan yeme bozukluğunun tedavisi ile dermatolojik sorunların çözümü de kolaylaşacaktır. Bu çalışmada AN, BN, tıkınırcasına yeme bozukluğu, pika, kaçıngan/kısıtlayıcı yiyecek alımı bozukluğundaki dermatolojik belirtiler gözden geçirilmiştir.
Building Cybersecurity Culture in Education as Imperative for Youth to Thrive in Digital Society
Authors: Gulyamov Said , Babaev Jahongir , Rakhmatov Uktam
Published: October 2024

This paper argues for integrating dedicated cybersecurity courses and programs within school and higher education curricula to drive mass cyber-socialization and develop responsible digital citizenship among youth. Immersive cybersecurity education through simulations, community linkages and holistic culture building can transform habits and mindsets to address risks like hacking, misinformation and privacy breaches students face online. Recommendations are provided for nationwide implementation through policy measures, public advocacy and educator capacity building. Mainstreaming cyber education can empower youth with competencies and values for secure and progressive digital futures.
Legal Aspects of Intellectual Property Protection in Web Development: Analysis of Contractual Obligations and Parties' Liability
Authors: Yashnarbekov Otaboy
Published: October 2024

This study examines the intricate legal landscape surrounding intellectual property (IP) protection in web development, focusing on contractual obligations and liability issues among involved parties. The research explores the various forms of IP relevant to web development, including copyrights, trademarks, and patents, while analyzing common contractual provisions used to safeguard IP rights, such as ownership clauses, confidentiality agreements, and licensing terms. Additionally, the study investigates the allocation of liability between developers, clients, and third-party service providers in cases of IP infringement. Through an examination of case studies and legal precedents, this research aims to provide insights into best practices for IP protection in web development projects and highlight potential legal pitfalls. The findings emphasize the importance of clear contractual language, due diligence in IP clearance, and proactive risk management strategies to mitigate liability concerns in the rapidly evolving digital landscape.
Liability Mechanisms and Dispute Resolution in Crypto Exchange Contracts: Balancing Code-Based Execution and Legal Enforceability
Authors: Nazarov Azizjon
Published: October 2024

This paper examines the tension between code-based execution and legal enforceability in smart contracts used by cryptocurrency exchanges. As decentralized finance grows in prominence, there is an increasing need to balance the immutability and automation of blockchain-based agreements with traditional legal protections and dispute resolution mechanisms. We analyze current approaches to liability allocation and conflict resolution in major crypto exchanges, identifying key challenges in harmonizing algorithmic governance with existing contract law. Case studies of recent exchange hacks and failures are used to illustrate the limitations of purely code-based systems. We then propose a hybrid model that preserves the efficiency of automated execution while incorporating safeguards for human intervention in exceptional circumstances. This framework aims to enhance user protections, regulatory compliance, and overall trust in decentralized financial infrastructure. Our findings have implications for exchange operators, regulators, and contract law as it evolves to address blockchain-enabled agreements.
The Relationship Between The Intensity of Using Tiktok Social Media on Self-Confidence in College Students
Authors: Sari Ayu Guspita , Subardjo Ratna Yunita Setiani
Published: October 2024

This research aims to analyze the relationship between the intensity of TikTok social media use and confidence in students, to find out the increase in confidence in the intensity of TikTok social media use in students, and to find out whether the intensity of TikTok social media use decreases confidence in students. The research approach carried out is quantitative. The data collection technique in this study is a list of questions (questioner). Data was collected through a questionnaire shared with 384 active student respondents at various Indonesian universities who used TikTok social media. In this study, the results of the analysis showed a significant positive relationship between the intensity of TikTok social media use and self-confidence. So, it can be said that there is a relationship between the intensity of TikTok social media use and confidence. Thus, students who intensely use TikTok social media experience an increase in confidence and students who intensely use TikTok social media do not experience a decrease in confidence. This finding is expected to provide students with insight into the intensity of TikTok social media use and how it can affect self-confidence. Therefore, students need to use TikTok social media wisely to choose to watch positive videos in order to increase their confidence.
An analysis of the role of disinformation in elections
Authors: Sivalo Delta
Published: October 2024

Electoral disinformation poses a significant threat to democratic processes, particularly in politically polarised environments like Zimbabwe. This paper examines the efficacy of the CITE project, a six-month high-impact initiative aimed at countering electoral disinformation during the August 2023 plebiscite. The primary objective was to mitigate the impact of disinformation on citizen participation by training citizens and community journalists to identify, flag, and combat misinformation. Methodologically, the study employed a qualitative exploratory approach, including workshops, social media campaigns, and a systematic desk review of existing literature and primary data sources. Key findings indicate that the project successfully raised awareness about disinformation, reaching over 100,000 people on Facebook with a campaign debunking election boycott rumours. However, the initiative faced limitations such as poor internet connectivity in rural areas and resistance from political actors benefiting from disinformation. The study underscores the importance of tailored strategies for different media platforms and highlights the efficacy of infographics and low-literacy data packaging methods in building trust. The research also identifies the need for multi-stakeholder collaboration and the potential of AI and machine learning in detecting disinformation. The significance of this work lies in its contribution to understanding the dynamics of disinformation in electoral processes and its practical implications for enhancing media literacy and democratic engagement. By comparing Zimbabwe's challenges and solutions with those of other countries, the study offers valuable insights for developing robust counter-disinformation strategies globally.
The Zimbabwe political space
Authors: Mutizwa Admire , Munhape Josphine , Munemo Sandra , Marenga Davison
Published: October 2024

Zimbabwe's post-independence election processes have been predominantly male-dominated, with women relegated to the periphery as electorates or party ‘cheerleaders’. Since the Beijing conference in 1995, Zimbabwe enacted several laws to overcome bottlenecks that have impeded women's participation in political processes, with the 2013 Constitution serving as the ultimate template for promoting women's engagement in mainstream electoral systems. Nonetheless, women’s participation as candidates or leaders in electoral processes has declined significantly since the 2013 Constitution. The study brings to the fore, findings to respond to 3 fundamental research questions which are: 1) what is the interlinkage between economic, cultural, social, and physical spaces with the electoral processes, 2) what are the complex social inclusion factors in political spaces, and 3) what recommendations can be proffered to enhance inclusion of women in electoral processes. In answering the questions, the research draws on content analysis of reports from the Project on Preventing Violence Against Women in Politics Project (VAWP/E), face-to-face interviews, and focus group discussions to offer insights and investigate the opportunities provided by various legal frameworks to increase women's engagement in electoral and political processes in Zimbabwe. The article further systematically explores other important factors and elements that impede and contribute to women's full participation in electoral processes as candidates. This study contends that the availability of excellent legal provisions does not result in increased women's participation in electoral politics as candidates unless there is political will. The study further asserts that participation in social, cultural, economic, and physical spaces interacts in a complex manner and influences women's participation in Zimbabwe's electoral political processes as candidates. Because of the country's political polarisation and the impunity of perpetrators of political violence, the political arena is believed to be intimidating and discouraging, thus not ripe, for women to participate as candidates. The study recommends a wholesome approach to dismantling the complex interlinkages between cultural, social, economic, and physical spaces as obstacles affecting the inclusion of women in electoral processes as candidates. Thus, the study further recommends that existing legal instruments should be complemented by progressively dismantling the social, cultural, and physical forces prohibiting women's participation as leaders in electoral processes. Specific provisions in the Electoral Act may further be used to penalise failure by political parties to field a reasonable number of women as candidates in elections.
Proximate Analysis On Nile Tilapia Artificial Feed From Shrimp Waste
Authors: Saputri Nanda Fathia , Putri Asha Arning
Published: October 2024

Nile Tilapia (Oreochromis niloticus) is the most widely cultivated freshwater fish because it can grow well in tropical countries and temperate regions. This research aims to create artificial feed that matches the nutritional parameters needed by nile tilapia. This artificial feed will use the basic ingredients of shrimp waste, with addition of oilcake, bran, starch flour, vitamins, squid oil, and water. There are four variables used to make artificial feed with different basic and additional ingredients, as well as varied processing techniques. After artificial feed is completed, proximate analysis will be carried out to test composition of crude fiber, carbohydrates, water, fat, ash, and protein using various methods. The test method for the composition of crude fiber, carbohydrates, fat, ash, and protein follows the method set by the Association of Official Analytical Chemists (AOAC). Based on the results of proximate analysis, variable 1 (V1) has fulfilled the nutritional content of protein and moisture content needed by nile tilapia. This shows that artificial feed formulations from shrimp waste can be used because protein is an important element for nile tilapia growth, but the content of crude fiber, carbohydrates, fat, and ash exceeds ideal value for nile tilapia nutrition. This also occurs in variables 2, 3, and 4 that have not met nutritional needs, especially protein. However, the composition of artificial feed with shrimp waste and addition of meal, bran, starch flour, vitamins, and water in V1 can be further investigated to reduce the content of crude fiber, carbohydrates, fat, and ash.