bluuebunny/crossref_metadata_2025 huggingface dataset:
Can handheld POC capillary lactate measurement be used with arterial and venous laboratory testing methods in the identification of sepsis?
Authors: Lightowler Bryan , Hoswell Anthony
Published: August 2016

Background:

The aim of this review was to examine whether the measurement of lactate in capillary blood samples using point-of-care handheld analysers corresponds sufficiently closely with arterial and venous whole-blood samples analysed by hospital central laboratory or blood gas analyser to be used interchangeably.

Methods:

A systematic search, informed by focused inclusion/exclusion criteria, was performed using multiple databases up to October 2015. A total of 65 articles were considered to have potential relevance and were evaluated in full text, of which ultimately five articles met all inclusion/exclusion criteria, and a final four were selected after data extraction and quality appraisal.

Results and Conclusion:

All four studies found a predominantly upward bias in the measurement of lactate in capillary samples tested using a handheld point-of-care device over arterial or venous samples tested by laboratory methods or blood gas analyser. In terms of correlation, there was consensus between the studies that the strength of association between the two methods of measurement was statistically significant. Three studies directly examined the extent of agreement between point-of-care capillary lactate measurements and those of laboratory or blood gas analyser reference determined to ±2 standard deviations; 95% confidence intervals, and report contextually broad limits of agreement, identifying a potential for both over triage and, to a lesser extent, under triage. The findings of the review do not support interchangeable use of handheld fingertip point-of-care lactate measurement with laboratory or blood gas analyser methods in the identification of sepsis.
Guam, the Brown Tree Snake Invasion, and Suicide Prevention
Authors: Morgan Robert F.
Published: August 2016

A sample of vignettes from past and present psychological applications in tropical Guam with an assist from contemporary Singapore. An emphasis on cultural adaptation to an invasion of brown tree snakes is followed by antidotes to teen suicide subsequent a high profile suicidal event. A chaos theory perspective is suggested.
The Malaysian People of the Dream and Traumatic Nightmare Intervention
Authors: Morgan Angel Kwan-Yin
Published: August 2016

The anthropological description of Senoi dream culture in tropical Malaysia has over the decades led to current psychological application and intervention for traumatic nightmares across any point in the lifespan.
Flashback Trauma Intervention and the Hawaiian Prison Softball Community
Authors: Shapiro Jerrold Lee
Published: August 2016

A tropical vignette case history of flashback trauma for a Vietnam veteran beginning with a prison softball game.
Aortic Coarctation 28 Days after an Arterial Switch Operation in a Neonate
Authors: Shikata Fumiaki , Okamura Toru , Higaki Takashi , Okura Masahiro , Kojima Ai , Uchita Shunji , Izutani Hironori
Published: August 2016

Aortic coarctation rarely occurs after an arterial switch operation for D-transposition of the great arteries with intact ventricular septum. We report the case of a neonate patient in whom aortic coarctation developed 28 days after an uncomplicated arterial switch operation. Preoperatively, the aorta was noted to have an irregular shape, but there was no pressure gradient across the lesion. The patient underwent successful reoperation to correct the coarctation. We hope that our report raises awareness of a rare early complication after arterial switch operation with intact ventricular septum, and the need to carefully monitor the aortic isthmus in patients who have aortic irregularities, even in the absence of a pressure gradient.
Right Ventricular Outflow Tract Obstruction Caused by Isolated Sinus of Valsalva Aneurysm
Authors: Abu Saleh Walid K. , Lin Chun Huie , Reardon Michael J. , Ramlawi Basel
Published: August 2016

Isolated sinus of Valsalva aneurysm is a rare occurrence, with an incidence of <1.5% among congenital heart disease repairs in the world. We recount the case of a 64-year-old man who presented with right-sided heart failure symptoms caused by a severely dilated right coronary sinus of Valsalva aneurysm that substantially obstructed the right ventricular outflow tract. Successful surgical repair involved right ventricular outflow tract resection and subcoronary patch repair.
Teachers’ metaphorical images on “counting jingle – it – playground” in children’s plays of Turkish culture
Türk kültüründeki çocuk oyunlarında “saymaca-ebe-oyun alanı” üzerine öğretmen metaforları
Authors: Kabadayı Abdülkadir
Published: August 2016

It is a fact that play, indispensible part of child in Turkish cultural and educational system, is the most effective tool to develop children’s emotional, mental, moral, social, personality and native language. In recent years, it has been seen that there is a considerable increase in the researches involving the functions of the children’s plays in respect of metaphor, as in the other parts of the plays. In this respect, play gains importance as the most effective educational tools as an educational campus for children, their peers as their teachers, natural materials like stone, sand, water and tree they use. In this study, “'Choosing rhyme -It-Playground” elements comprising traditional children’s games are handled based on pre-service teachers’ metaphorical images. In the qualitative research, content analysis of 23 metaphors the pre-service teachers produced in the “'Choosing rhyme-It-Playground” context is done and explained. The participants put forward how they perceived Choosing rhyme, It and Playground separately via 72 sub-theme by generating human metaphors like “Voting-Deputy-Voting box”, animal metaphors like “Fishing rod-Fish-Sea” and object metaphors like “Probing-Sample-Cereal Sack” As a last remark, some recommendations are made to the parents and teachers to maintain this traditional culture inherited from our ancestors. ÖzetTürk kültüründe ve eğitim sisteminde, çocuğun ayrılmaz bir parçası olan oyunun, çocuğun duygusal, zihinsel, ahlaki, sosyal, kişilik ve ana dil bakımından gelişiminin en etkili aracı olduğu bilinen bir gerçektir. Son yıllarda, oyunun diğer alanlarında olduğu gibi, çocuk oyunlarının fonksiyonlarını, metaforik açıdan ele alan araştırmaların sayısında gözle görülür bir artma eğiliminde olduğu görülmektedir. Bu anlamda oyun, çocuk için bir eğitim merkezi, akranları birer öğretmen, oyun içinde kullandıkları, taş, toprak, su ve ağaç gibi doğal malzemeleri de en etkili eğitim araçları olarak önem kazanmaktadır. Bu çalışmada, geleneksel çocuk oyunlarını meydana getiren “Saymaca-Ebe-Oyun alanı” unsurları öğretmen adaylarının metaforik algıları üzerine ele alınmıştır. Bu nitel çalışmada öğretmen adaylarının “Saymaca-Ebe-Oyun alanı” bağlamında ürettiği 23 metaforun içerik analizi yapılarak açıklanmaya çalışılmıştır. Katılımcılar, “Saymaca-Ebe-Oyun Alanı” bağlamını, “Seçim-Milletvekili-Sandık” gibi insan metaforları; “Olta-Balık-Deniz” gibi hayvan metaforlarını ve “Sonda-Numune-Hububat Çuvalı” gibi nesne metaforlarını kullanarak 72 alt tema oluşturmuşlar ve Saymaca, Ebe ve Oyun alanını kültürel olarak nasıl algıladıklarını ortaya koymuşlardır. Sonuç olarak, Atalarımızdan bizlere miras kalan bu geleneksel kültürün sürdürülmesi için öğretmen ve ebeveynlere bazı tavsiyelerde bulunulmuştur.
WiSeDB
Authors: Marcus Ryan , Papaemmanouil Olga
Published: August 2016

Workload management for cloud databases deals with the tasks of resource provisioning, query placement, and query scheduling in a manner that meets the application's performance goals while minimizing the cost of using cloud resources. Existing solutions have approached these three challenges in isolation while aiming to optimize a single performance metric. In this paper, we introduce WiSeDB, a learning-based framework for generating
holistic
workload management solutions customized to application-defined performance goals and workload characteristics. Our approach relies on supervised learning to train cost-effective decision tree models for guiding query placement, scheduling, and resource provisioning decisions. Applications can use these models for both batch and online scheduling of incoming workloads. A unique feature of our system is that it can adapt its offline model to stricter/looser performance goals with minimal re-training. This allows us to present to the application alternative workload management strategies that address the typical performance vs. cost trade-off of cloud services. Experimental results show that our approach has very low training overhead while offering low cost strategies for a variety of performance metrics and workload characteristics.
Streaming similarity self-join
Authors: De Francisci Morales Gianmarco , Gionis Aristides
Published: August 2016

We introduce and study the problem of computing the similarity self-join in a streaming context (SSSJ), where the input is an unbounded stream of items arriving continuously. The goal is to find all pairs of items in the stream whose similarity is greater than a given threshold. The simplest formulation of the problem requires unbounded memory, and thus, it is intractable. To make the problem feasible, we introduce the notion of
time-dependent similarity:
the similarity of two items decreases with the difference in their arrival time.

By leveraging the properties of this time-dependent similarity function, we design two algorithmic frameworks to solve the SSSJ problem. The first one, MiniBatch (MB), uses existing index-based filtering techniques for the static version of the problem, and combines them in a pipeline. The second framework, Streaming (STR), adds
time filtering
to the existing indexes, and integrates new time-based bounds deeply in the working of the algorithms. We also introduce a new indexing technique (L2), which is based on an existing state-of-the-art indexing technique (L2AP), but is optimized for the streaming case.

Extensive experiments show that the STR algorithm, when instantiated with the L2 index, is the most scalable option across a wide array of datasets and parameters.
S2RDF
Authors: Schätzle Alexander , Przyjaciel-Zablocki Martin , Skilevic Simon , Lausen Georg
Published: August 2016

RDF has become very popular for semantic data publishing due to its flexible and universal graph-like data model. Thus, the ever-increasing size of RDF data collections raises the need for scalable distributed approaches. We endorse the usage of existing infrastructures for Big Data processing like Hadoop for this purpose. Yet, SPARQL query performance is a major challenge as Hadoop is not intentionally designed for RDF processing. Existing approaches often favor certain query pattern shapes while performance drops significantly for other shapes. In this paper, we introduce a novel relational partitioning schema for RDF data called ExtVP that uses a semi-join based preprocessing, akin to the concept of Join Indices in relational databases, to efficiently minimize query input size regardless of its pattern shape and diameter. Our prototype system S2RDF is built on top of Spark and uses SQL to execute SPARQL queries over ExtVP. We demonstrate its superior performance in comparison to state of the art SPARQL-on-Hadoop approaches.
A framework for annotating CSV-like data
Authors: Arenas Marcelo , Maturana Francisco , Riveros Cristian , Vrgoč Domagoj
Published: August 2016

In this paper, we propose a simple and expressive framework for adding metadata to CSV documents and their noisy variants. The framework is based on annotating parts of the document that can be later used to read, query, or exchange the data. The core of our framework is a language based on extended regular expressions that are used for selecting data. These expressions are then combined using a set of rules in order to annotate the data. We study the computational complexity of implementing our framework and present an efficient evaluation algorithm that runs in time proportional to its output and linear in its input. As a proof of concept, we test an implementation of our framework against a large number of real world datasets and show that it can be efficiently used in practice.
Uncertainty, Innovation, and Dynamic Capabilities: An Introduction
Authors: Teece David , Leih Sohvi
Published: August 2016

This special issue draws on a range of intellectual roots—ranging from financial economics to organization theory, to design theory, and to human cognition. The goal of this special issue is to bring scholars from different disciplines together with practitioners who have had success applying the framework so as to help other managers lead their organizations to higher levels of performance.
Designing Organizations for Dynamic Capabilities
Authors: Felin Teppo , Powell Thomas C.
Published: August 2016

How can organizations put dynamic capabilities into practice? This article focuses on the power of organizational design, showing how managers can harness new organizational forms to build a capacity for sensing, shaping and seizing opportunities. Fast-moving environments favor open organization and self-organizing processes that quickly convert individual capabilities into actionable collective intellect. However, such self-organizing processes require managers to design and execute them. Using Valve Corporation as a case example, this article shows how new design principles—such as polyarchy, social proofs, and new forms of open organization—allow organizations to build dynamic capabilities for sustained innovation in dynamic environments.
Limited value for urinary 5-HIAA excretion as prognostic marker in gastrointestinal neuroendocrine tumours
Authors: Zandee Wouter T , Kamp Kimberly , van Adrichem Roxanne C S , Feelders Richard A , de Herder Wouter W
Published: August 2016

Objective

To determine if urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion is of prognostic value for overall survival (OS) in patients with a gastrointestinal neuroendocrine tumour (NET) and to compare the prognostic value with patient characteristics, ENETS/WHO grading, ENETS TNM staging and biomarkers.

Design and methods

Data was collected from patients with a gastrointestinal NET or a NET with gastrointestinal metastases and available 5-HIAA excretion in 24-h urine samples. Laboratory results were stratified for urinary 5-HIAA and chromogranin A (CgA): <2× upper limit of normal (ULN), 2–10× ULN, or >10× ULN. For neuron-specific enolase (NSE), this was the reference range or >1× ULN. OS was compared using Kaplan−Meier and log-rank tests, and hazard ratios were calculated using Cox regression for univariate and multivariate analyses.

Results

A total of 371 patients were included, 46.6% female with a mean age of 59.9 years. OS was shortest in patients with urinary 5-HIAA excretion >10× ULN vs reference range (median 83 months vs 141 months, P = 0.002). In univariate analysis, urinary 5-HIAA excretion >10× ULN was a negative predictor (HR 1.62, 95% CI: 1.09–2.39). However, in multivariate analysis, only age (HR 1.04, 95% CI: 1.01–1.08), grade 3 disease (HR 5.09, 95% CI: 2.20–11.79), NSE >1× ULN (HR 2.36, 95% CI: 1.34–4.14) and CgA >10× ULN (HR 3.61, 95% CI: 1.56–8.34) remained as the predictors.

Conclusion

Urinary 5-HIAA excretion >10× ULN is a negative predictor for OS. However, when added to other biomarkers and grading, it is no longer a predictor for OS. Therefore, it should only be determined to assess carcinoid syndrome and not for prognostic value.
Biomarkers of subclinical inflammation and increases in glycaemia, insulin resistance and beta-cell function in non-diabetic individuals: the Whitehall II study
Authors: Herder Christian , Færch Kristine , Carstensen-Kirberg Maren , Lowe Gordon D , Haapakoski Rita , Witte Daniel R , Brunner Eric J , Roden Michael , Tabák Adam G , Kivimäki Mika , Vistisen Dorte
Published: August 2016

Objective

Higher systemic levels of pro-inflammatory biomarkers and low adiponectin are associated with increased risk of type 2 diabetes, but their associations with changes in glycaemic deterioration before onset of diabetes are poorly understood. We aimed to study whether inflammation-related biomarkers are associated with 5-year changes in glucose and insulin, HbA1c, insulin sensitivity and beta-cell function before the diagnosis of type 2 diabetes and whether these associations may be bidirectional.

Design and methods

We used multiple repeat measures (17 891 person-examinations from 7683 non-diabetic participants) from the Whitehall II study to assess whether circulating high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL6), IL1 receptor antagonist (IL1Ra) and adiponectin are associated with subsequent changes in glycaemia, insulin, insulin resistance and beta-cell function (based on oral glucose tolerance tests). We examined bidirectionality by testing if parameters of glucose metabolism at baseline are associated with changes in inflammation-related biomarkers.

Results

Higher hsCRP and IL6 were associated with increases in fasting insulin, insulin resistance and, for IL6, with beta-cell function after adjustment for confounders. Higher adiponectin was associated with decreases in fasting glucose, HbA1c, fasting insulin, insulin resistance and beta-cell function. The reverse approach showed that 2-h glucose and insulin sensitivity were associated with changes in IL1Ra. Fasting insulin and insulin resistance showed inverse associations with changes in adiponectin.

Conclusions

Subclinical inflammation is associated with development of increased glycaemia, insulin resistance and beta-cell function in non-diabetic individuals. These findings are consistent with the hypothesis that inflammation-related processes may increase insulin resistance and lead to a compensatory upregulation of beta-cell function.
Geographical distribution of Austrolebias monstrosus (Huber, 1995), A. elongatus (Steindachner, 1881) and A. vandenbergi (Huber, 1995) (Teleostei: Cyprinodontiformes), with comments on the biogeography and ecology of Rivulidae in Pampasic and Chaco floodplains
Authors: Alonso Felipe , Calviño Pablo Andrés , Terán Guillermo Enrique , García Ignacio
Published: August 2016

We present a new record for Austrolebias elongatus from Gualeguaychú, in Entre Ríos province, Argentina, based on new fieldwork and a revision of material deposited in national ichthyological collections. We also give evidence on the erroneous records of Austrolebias monstrosus and A. vandenbergi from Ituzaingó, Corrientes province, as well as present additional records from Salta province for those species. Material previously determined as A. elongatus from Santiago del Estero is attributed to A. monstrosus. We restrict the distribution of these two species to Semi-arid Chaco Region in Argentina, Paraguay and Bolivia.
Tradução e Adaptação Transcultural para o Português Brasileiro do Questionário Hearing Implant Sound Quality Index - (HISQUI19)
Authors: Caporali Priscila Faissola , Caporali Sueli Aparecida , Bucuvic Érika Cristina , Vieira Sheila de Souza , Santos Zeila Maria , Chiari Brasília Maria
Published: August 2016

RESUMO Objetivo Traduzir e adaptar transculturalmente o instrumento HISQUI19 (Hearing Implant Sound Quality Index), e caracterizar a população e o desempenho auditivo em usuários de Implante Coclear (IC) pela aplicação da versão síntese. Método Realizou-se a avaliação das equivalências conceitual, de item, semântica e operacional. A versão síntese foi aplicada como um pré-teste que contou com 33 sujeitos no resultado final, caracterizando a amostra e o desempenho do questionário. Os resultados foram analisados estatisticamente. Resultado A tradução final (TF) foi retrotraduzida e comparada à versão original, mostrando diferença mínima entre itens, e as modificações da TF para a versão síntese caracterizaram-se pela aplicação de vocabulário simplificado utilizado no cotidiano. No pré-teste, o escore médio entre os entrevistados foi de 90,2 e confirmou-se alto grau de confiabilidade interna (0,83). Conclusão A tradução e a adaptação do questionário HISQUI19 mostraram adequação para as equivalências semântica, cultural, conceitual e de item. Na caracterização da amostra, a qualidade de som foi classificada como boa com melhor desempenho nas categorias de localização e distinção de sons/vozes.
Direito e teorias ideal e não ideal da justiça
Authors: Zanitelli Leandro Martins
Published: August 2016

Resumo O artigo discute a importância de teorias ideais e não ideais da justiça para avaliar propostas de mudança pontual da legislação. Concordando, a esse respeito, com Sen (2006; 2009), defendo que teorias ideais (no sentido de teorias de “estado final”) não são nem necessárias nem suficientes para comparações entre sociedades imperfeitas. Isso, contudo, não significa que teorias ideais não possam ser úteis para essas comparações e, em consequência, para a avaliação de propostas de alteração do status quo. No entanto, à medida que uma teoria ideal se mostre um ponto de partida digno de consideração para as comparações relativas a alterações legislativas em circunstâncias não ideais, é preferível que a teoria em questão seja uma teoria total, isto é, que abranja a totalidade do objeto da justiça (no caso de teorias institucionalistas, como a de Rawls, a totalidade da estrutura básica da sociedade) em vez de se restringir a uma área do direito em particular.
Efeitos da ilha de calor nos níveis de conforto em ambientes externos e internos para as condições climáticas de Curitiba
Authors: Krüger Eduardo Leite
Published: August 2016

RESUMO: O crescimento urbano e o decorrente surgimento de ilhas de calor são fatores responsáveis não apenas por mudanças nos padrões de conforto e desconforto térmico urbanos mas também por possíveis impactos no aumento da demanda de energia (em climatização artificial) das edificações urbanas. Países em desenvolvimento, a maior parte deles localizada em regiões tropicais, apresentam taxas de crescimento urbano mais elevadas relativamente aos países desenvolvidos; segundo dados da ONU, no período de 2005 - 2010, a taxa de urbanização dos primeiros foi cerca de cinco vezes mais alta que a dos últimos. Nesse contexto, o objetivo do presente trabalho foi analisar a atual ilha de calor urbana de Curitiba, decorrente de seu considerável crescimento urbano nas últimas décadas, a partir de um monitoramento climático contínuo entre dezembro de 2011 e fevereiro de 2013 por meio de estações meteorológicas localizadas na mancha urbana. Adicionalmente à análise de diferenças na temperatura local, quantificaram-se níveis de conforto/desconforto térmico a fim de se verificar o efeito integrado das diversas variáveis meteorológicas em termos de percentuais de horas em frio, conforto e calor, e suas variações dentro e fora da área urbana. Complementarmente são analisadas implicações da ilha de calor urbana em níveis de conforto em ambientes internos. Verificou-se que a presença de uma ilha de calor na área urbana para combater o frio no inverno acarreta aumento desproporcional do calor em situação de verão, não havendo benefício térmico de maneira geral.
Population Genetics and Seed Set in Feral, OrnamentalMiscanthus sacchariflorus
Authors: Mutegi Evans , Snow Allison A. , Bonin Catherine L. , Heaton Emily A. , Chang Hsiaochi , Gernes Carole J. , Palik Destiny J. , Miriti Maria N.
Published: August 2016

Ornamental grasses may become invasive weeds depending on their ability to naturalize and outcompete other species.Miscanthus sacchariflorus(Maxim) Franch. (Amur silvergrass) is a tall, self-incompatible, nonnative grass that has become naturalized in eastern North America, forming monospecific stands and raising concerns about its potential invasiveness. To understand the extent of clonal and sexual reproduction in feral populations, we examined their population genetic structure, seed production, and ploidy. We surveyed 21 populations in Iowa and Minnesota using eight polymorphic microsatellite markers. Only 34 multilocus genotypes (MLGs) were detected from a total of 390 samples. All of the study populations had more than one MLG, thereby allowing cross-pollination with near neighbors, but most were dominated by one or a few MLGs. Low genetic divergence suggests that all populations may have originated from similar cultivars. Cluster analysis showed that the six populations from Minnesota were extremely similar to each other, whereas the 15 populations from Iowa were somewhat more diverse. Seed production was quantified for 20 populations and ploidy for 11 populations. Average seed production was very low (< 0.30 seeds per panicle), although most populations did produce seeds. Because the populations were diploid (2x), they also may have the potential to hybridize with ornamental varieties ofMiscanthus sinensis(Chinese silvergrass; eulaliagrass), a diploid close relative. Clonal growth, self-incompatibility, and spatial isolation of compatible clones may contribute to pollen-limited seed set in these populations. Low seed set may affect the rate of spread of feralM. sacchariflorus, which appears to disperse vegetatively as well as by seed. Although this species is not widely viewed as invasive, it is worth monitoring as a species that may become more widespread in the future.
Predicting Yield Losses in Rice Mixed-Weed Species Infestations in California
Authors: Brim-DeForest Whitney B. , Al-Khatib Kassim , Fischer Albert J
Published: August 2016

Although many pests constrain rice production, weeds are considered to be the major barrier to achieving optimal yields. A predictive model based on naturally occurring mixed-species infestations in the field would enable growers to target the specific weed group that is the greatest contributor to yield loss, but as of now no such models are available. In 2013 and 2014, two empirical hyperbolic models were tested using the relative cover at canopy closure of groups of weed species as independent variables: grasses, sedges, broadleaves, grasses and sedges combined, grasses and broadleaves combined, and all weed species combined. Models were calibrated using data from experiments conducted at the California Rice Experiment Station, in Biggs, CA, and validated across four sites over 2 years, for a total of 7 site-year combinations. Of the three major weed groups, grasses, sedges, and broadleaves, the only groups positively related to yield loss in the multispecies infestation were grasses. At the model calibration site, grasses and sedges combined best predicted yield loss (corrected Akaike information criterion [AICc]=−21.5) in 2013, and grasses alone best predicted yield loss (AICc=−19.0) in 2014. Across the validation sites, the model using grasses and sedges combined was the best predictor in 5 out of 7 site-years. Accuracy of the predicted values at the model validation sites ranged from 6% mean average error to 17% mean average error. No single model and set of parameters accurately predicted losses across all years and locations, but relative cover of grasses and sedges combined at canopy closure was the best estimate over the most sites and years.
Value of Donor–Specific Anti–HLA Antibody Monitoring and Characterization for Risk Stratification of Kidney Allograft Loss
Authors: Viglietti Denis , Loupy Alexandre , Vernerey Dewi , Bentlejewski Carol , Gosset Clément , Aubert Olivier , Duong van Huyen Jean-Paul , Jouven Xavier , Legendre Christophe , Glotz Denis , Zeevi Adriana , Lefaucheur Carmen
Published: August 2016

The diagnosis system for allograft loss lacks accurate individual risk stratification on the basis of donor–specific anti–HLA antibody (anti-HLA DSA) characterization. We investigated whether systematic monitoring of DSA with extensive characterization increases performance in predicting kidney allograft loss. This prospective study included 851 kidney recipients transplanted between 2008 and 2010 who were systematically screened for DSA at transplant, 1 and 2 years post-transplant, and the time of post–transplant clinical events. We assessed DSA characteristics and performed systematic allograft biopsies at the time of post–transplant serum evaluation. At transplant, 110 (12.9%) patients had DSAs; post-transplant screening identified 186 (21.9%) DSA-positive patients. Post–transplant DSA monitoring improved the prediction of allograft loss when added to a model that included traditional determinants of allograft loss (increase in c statistic from 0.67; 95% confidence interval [95% CI], 0.62 to 0.73 to 0.72; 95% CI, 0.67 to 0.77). Addition of DSA IgG3 positivity or C1q binding capacity increased discrimination performance of the traditional model at transplant and post-transplant. Compared with DSA mean fluorescence intensity, DSA IgG3 positivity and C1q binding capacity adequately reclassified patients at lower or higher risk for allograft loss at transplant (category–free net reclassification index, 1.30; 95% CI, 0.94 to 1.67; P<0.001 and 0.93; 95% CI, 0.49 to 1.36; P<0.001, respectively) and post-transplant (category–free net reclassification index, 1.33; 95% CI, 1.03 to 1.62; P<0.001 and 0.95; 95% CI, 0.62 to 1.28; P<0.001, respectively). Thus, pre– and post–transplant DSA monitoring and characterization may improve individual risk stratification for kidney allograft loss.
El consumo de drogas en estudiantes de México: tendencias y magnitud del problema
Authors: Villatoro Velázquez Jorge Ameth ,   Dirección de investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz., Medina-Mora Ma Elena , Martín del Campo Sánchez Raúl , Fregoso Ito Diana Anahí , Bustos Gamino Marycarmen Noemí , Resendiz Esbehidy , Mujica Roxana , Bretón Michelle , Soto Itzia Sayuri , Cañas Vianey ,   Dirección General del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz.,   Comisión Nacional contra las Adicciones.
Published: August 2016

Resumen

Introducción. El consumo de drogas y sus consecuencias sociales y de salud son del interés de múltiples sectores. Las encuestas en estudiantes son estrategias epidemiológicas para monitorear el problema, las cuales se complementan con encuestas de hogares y en grupos especiales de la población, lo que permite ver anticipadamente fenómenos que posteriormente son evidentes en la población general. Además de las tendencias y del patrón de consumo de drogas, estos estudios muestran la influencia de otros factores que incrementan el uso y sus consecuencias.

Objetivo. Conocer las prevalencias de uso de drogas, alcohol y tabaco en estudiantes de primaria (5° y 6°) y secundaria-bachillerato de México y sus Estados.

Método. Es una encuesta probabilística en población escolar 5º y 6º de primaria, secundaria y bachillerato con representatividad nacional y de cada Estado del país. La muestra fue de 52 171 alumnos en primaria y 114 364 en secundaria-bachillerato. La información se obtuvo mediante un cuestionario estandarizado y validado en encuestas anteriores.

Resultados. El consumo de tabaco alguna vez fue de 30.4% y la edad promedio de inicio de esta sustancia fue 13.4 años. El 53.2% ha bebido alcohol y 14.5% ha bebido en exceso. La prevalencia de consumo de drogas alguna vez fue de 17.2%. Las drogas de preferencia son la mariguana (10.6%), seguida de inhalables (5.8%) y cocaína (3.3%).

Discusión y conclusión. El crecimiento del consumo de sustancias, principalmente mariguana y alcohol, resalta la importancia de la creación de nuevas estrategias de prevención para disminuir los índices de consumo entre los estudiantes.
Induced pluripotent stem cells differentiation into cardiomyocytes by rotating suspension culture and in specific plates with microwells
Authors: Budash G. , Bilko N.
Published: August 2016

In order to enhance the differentiation of induced pluripotent cells into cardiomyocytes, we compared two methods of embryoid bodies formation: differentiation in rotating suspension culture and formation of embryoid bodies from a predetermined number of pluripotent stem cells in microwells of AggreWell plates. We used transgenic murine induced pluripotent stem cell line AT25. Cell line expressed IRES-flanked enhanced green fluorescent protein (eGFP) under the control of cardiac alpha myosin heavy chain promoter (αMHC). We applied flow cytometry and fluorescence microscopyin order to test the efficiency of differentiation processes. Thus, differentiation of pluripotent stem cells in AggreWell plates without adding differentiation factors was more effective than differentiation in rotating suspension culture. However, we obtained the most amounts of cardiomyocytes on the 11-th day in rotating suspension culture with ascorbic acid, after we applied dorsomorfin, DMSO, ascorbic acid, G-CSF with the above-mentioned methods. The amount of GFP + cells was 2,71 ± 0,07%.
Social and Communication Technologies of Propagandism of the Links among Europe, Germany and Ukraine in Press of the Reichcommissariat “Ukraine” (in the period from 1 September 1941 to 17 July 1942)
Authors: Kholod Alexander
Published: August 2016

Three aspects of the problem are studied in this research. The first aspect is the lack of knowledge about a range of European-Ukrainian and German-Ukrainian relations covered by the press controlled by the Reichcommissariat “Ukraine” (hereinafter – RCU) in the period from its foundation up to the beginning of the Battle of Stalingrad. The second aspect is the lack of studies on the identification and description of the specific social and communication technologies of influence through the RCU press on the minds of readers. The third aspect is the inaccuracies detected in previous studies by Ukrainian researchers, in descriptions of methods used in newspapers published under the RCU censorship. To fill these gaps in knowledge, the author has chosen as an object of study the press (newspapers) of the Reichcommissariat “Ukraine” from 1 September 1941 to 17 July 1942. The subject of the study is the range and trends in the Ukrainian-European and Ukrainian-German relations covered by the RCU press in the given period.

In the study, the author identified the range and trends in covering the Ukrainian-European and Ukrainian-German relations in the press of the Reichcommissariat “Ukraine” in the period from 1 September 1941 to 17 July 1942. The main results of the study are the differentiations of journalistic materials in the specified period by two criteria. By the first criterion, we identified a range of topics in journalistic materials, both in quantity and quality, in the following two groups: “Ukrainian-European relations” and ” Ukrainian-German relations.” By the second criterion of the analysis (the quantity and quality of the main trends of Ukrainian-European and Ukrainian-German relations covered by the RCU press from the first day of its foundation, 1 September 1941, to the first day of the Battle of Stalingrad, 17 July 1942) four main trends were outlined, namely: 1) insisting of the RCU press on rightness of Germany’s war against the Bolshevism; 2) imposing of the idea of necessity to work aiming at assisting the German soldiers; 3) promotion of the idea of precedence of German culture as a model for the Ukrainians; 4) propagandism of the advantages of the new, German order in Ukraine.

The study confirmed the author’s hypothesis that in the period prior to the Battle of Stalingrad, the RCU newspapers employed the social and communication technologies of propaganda to more intensively promote the Ukrainian-German relations than the Ukrainian-European relations.
Content Verification in Social Media
Authors: Ryabichev Vyacheslav
Published: August 2016

The main objectives of the study are: elaboration of the operative algorithm for professional online journalists under information warfare (IW) conditions; analysis of the modern methods and tools for the effective verification of information; application of the decision support systems (DSS) for the content distribution in social media; specification of the set of rules for network reporters to itemize their activity.

In this study the issue of verifying the information received from the World Wide Web is analysed, in particular, the information spread during the military aggression of the Russian Federation against Ukraine in 2014–2015. We also present and justify some modern means of counteracting the spread of intentionally distorted information and hostile propaganda. We focus on using content analysis, comparative analysis, full-text searching, pattern recognition, and open-source intelligence (OSINT) method.

Through using specific facts and findings we analyse the features of the work of an online journalist during the warfare and modern digital tools for content search, verification, comparison and analysis.

The results and conclusions of this investigation allow generalizing and structuring some methods and techniques of content verification. A number of rules and helpful hints for enhancing the efficiency of online journalists are proposed. Current trends in development of social media allow predicting further increase of the Internet audience and consequently an increasing amount of information on the web. With the development of citizen journalism (street journalism) in Ukraine, the significance level of journalistic responsibility for information dissemination in mass media has been constantly increasing. Out of a huge amount of reports and data, a journalist must be able to identify the most accurate and up-to-date ones, check them promptly, and distribute on cross-media platforms. Under such conditions, an online reporter is obliged to possess modern skills of dealing with digital tools for content verification, and to keep in contact with experts whom he can ask for advice.
Synthesis and Investigation of Polymerization Properties of Methacrylic Monomers with Chiral Fragments
Authors: Nadtoka Oksana , Gerasimenko Anton , Syromyatnikov Vladimir
Published: August 2016

Methacrylic monomers containing chiral moieties and azobenzene derivatives were synthesized. As the chiral component was used menthol. The polymerization properties of monomer (5-methyl-2- (1-methyl)cyclohexanol with azomonomers were studied and the reactivity ratios as well as parameters Q and e characterizing the activity of the obtained monomers have been calculated. On basis of the synthesized monomers were synthesized chiral-photochromic copolymers and their absorption spectra were studied. It was shown that in the copolymers absorption spectra the absorption maxima are in the wavelength region of 340-360 nm and correspond to trans-form of azo fragments.
New coordination compounds of uranyl ion with 3-(2-hydroxyphenyl)-1,2,4-triazole and its derivatives: synthesis and investigation of spectral properties
Authors: Vashchenko Oleksandr , Khomenko Dmytro , Doroschuk Roman , Lampeka Rostyslav
Published: August 2016

New methods of 3-(2-hydroxyphenyl)-1,2,4-triazoles synthesis were developed. Obtained ligands was used for synthesis of three new complex compounds of uranyl-ion with general composition [UO2(HL)2(Solv)]. These compounds were characterized by NMR and IR spectroscopy.
First insights into the synthesis of carbo-phospholane and carbo-phospholene oxides
Authors: Maurette Luc , Saccavini Catherine , Maraval Valérie , Chauvin Remi
Published: August 2016

Fifteen-membered ring carbo-mers of five-membered rings are considered in the heterocyclic series of the phosphole oxide and less unsaturated parents. The synthesis of the first carbo-phospholane oxides is achieved by a [14+1] two-step/one-pot macrocyclization route with 86 % yield. Reduction of the latter phosphora-[5]pericyclyne with SnCl­2 allowed consistent 1H and 31P NMR characterization of the corresponding carbo-phospholene, produced with 11 % yield. The ultimate carbo-phosphole oxide could not be isolated, but preliminary results on alternative strategies towards this 14 pz-electron Hückel carbo-aromatic are reported.
A study of nonstoichiometric oxides in the Ln-Ni-O (Ln=La, Pr, Nd) system
Authors: Kulichenko Vadim , Nedilko Sergiy , Dziazko Olexander , Chornovol Victoria
Published: August 2016

The non-stoichiometric compositions Ln2-xNiO4-3x/2+d (Ln=La, Pr, Nd, 0£x£0,4) were obtained using coprecipitation method from nitrates solutions by K2CO3 followed by calcination of the obtained blend at 950°С. According to X-ray phase analysis compositions in the range La2NiO4.17 – La1.6NiO3.63 are monophase and crystallize in tetragonal symmetry K2NiF4, space group I4/mmm. Nd2-xNiO4-y and Pr2-xNiO4-y in the range 0£x£0,2 are monophase and have orthorombic and monoclinic(correspodingly) distorted K2NiF4 structure. Samples with 0,2<x£0,4 are polyphase and contain Ln2NiO4 (Ln=Pr, Nd), NiO and rare earth oxides. Electrical conductivity of obtained samples have semiconducting behavior and it is strong depended to nonstoichiometric oxygen content.
Caminhos da construção de uma Avaliação Institucional Participativa
Authors: Dalben Adilson
Published: August 2016

Este artigo apresenta a constituição conceitual da Avaliação Institucional Participativa (AIP) e sua formatação no Projeto Geres-AI, na política educacional na cidade de Campinas e na reforma do Sistema de Inspeção Educativa em Angola. Trata-se de um modelo proposto pelo Laboratório de Observação e Estudos Descritivos (LOED) da Universidade Estadual de Campinas que tem como finalidade a melhoria da qualidade social oferecida nas escolas. Após a apresentação do contexto em que surge a avaliação institucional enquanto processo contrarregulatório, são descritos os principais movimentos nessas três experiências, explicitando as características do modelo, seus conceitos centrais e pressupostos, além da importância do protagonismo da comunidade escolar. É evidenciada a sinuosidade das trajetórias de implementação, dada a influência de diversos fatores, requerendo, por isso, planejamento e apoio dos órgãos governamentais.
Antiulcer Activity after Oral Administration of the Wormwood Ethanol Extract on Lesions due to Leishmania major Parasites in BALB/C Mice
Authors: Azizi Kourosh , Shahidi-Hakak Fatemeh , Moemenbellah-Fard Mohammad Djaefar , Asgari Qasem , Mohammadi-Samani Soliman
Published: August 2016

Herbal extracts were used to investigate the in vivo efficacy of Artemisia absinthium on the treatment of cutaneous leishmaniasis in susceptible mice. A total of 40 BALB/c mice were subjected to assays. In each, 3-5×103 amastigotes of standard Leishmania major strain were inoculated subcutaneously into the tail base of mice. Groups of mice were assigned as: I-negative control, II-positive control, III-Glucantime®, IV-ointment twice a day, V-ointment with oral medicine, VI-oral medicine on parasite injection, VII-oral medicine once ulcer develops, and VIII-ointment-based crème on ulcer. The gold standard of clinical infection control was based on ulcer size measurement using a Vernier scale weekly during 4 weeks Post-Ulcer Development (PUD). The mean ulcer sizes in different groups were compared using the post hoc Dunnett's 3 statistical analyses. There was a significant difference between the two groups of ointment with medicine (V) and medicine on parasite inoculation (VI) (P ≤ 0.027). Antiulcer activity and healing was noted after oral treatment with aqueous extract on parasite injection. There was a significant difference between data from positive control group and local ointment with oral medicine (P ≤ 0.045) indicating that ointment use facilitated ulcer growth. There was also a significant difference between data from Glucantime® use and ointment with medicine group (P ≤ 0.039) which showed the deteriorating effect of oil-based ointment use. The oral administration of extract had an effect similar to Glucantime® use and led to the repair of ulcer. A. absinthium extract as oral feeder appeared to cause modulation of host responses, ulcer size reduction and tissue repair.
 
Vários autores
Authors: Schaan Denise P.
Published: August 2016

Láercio Fidelis Dias, Santiago Wolnei Ferreira Guimarães, Edimar Antonio Fernan, Marina de Castro, Daniel Sombra.
O SERINGAL PORONGABA: MEMÓRIAS DE UM PASSADO CONSTRUÍDO
Authors: Narahara Karine
Published: August 2016

Este artigo enfoca elementos da história de um seringal localizado na beira do rio Iaco, leste do estado do Acre, a partir da narrativa de seus moradores. Trata-se de um passado construído que aponta para a perda da centralidade do cortar seringa no cotidiano das colocações, com a saída de cena dos patrões de antigamente e a desestruturação dos seringais empresa.Neste contexto, muitos grupos domésticos abandonaram o seringal, transferindo-se para a rua (áreas urbanas) ou para outras áreas rurais. Entretanto, muitos outros seguiram vivendo lá, indicando que outros fatores, além do econômico, foram levados em consideração.Palavras-chave: Reserva extrativista, seringal, seringueiros, castanha doBrasil, Amazônia, Acre, rio Iaco.
HERMENÊUTICA E EXPERIÊNCIA ESTÁTICA EM CORPO DE BAILE
Authors: HOLANDA Silvio Augusto de Oliveira
Published: August 2016

Este artigo visa a discutir a recepção crítica de Corpo de Baile, de Guimarães Rosa, à luz do conceito de experiência estética formulado por Jauss (1979). Com base na hermenêutica literária proposta pelo pensador alemão, pode- se interpretar Corpo de Baile como a exaltação à literatura e ao corpo da linguagem. É possível pensar o ciclo narrativo como ciclo poético, elaboração formal e critica fundidos em um único objeto estético, e, ao mesmo tempo, refletir sobre a dimensão estética do homem. Buscar a  hermenêutica para compreender a obra literária conduz-nos a perceber distinções fundamentais, tais como entre livro e mundo, objeto interpretado e sujeito interpretante. Assim, para uma compreensão de Corpo de Baile, é preciso minimizar as manifestações implícitas de Guimarães Rosa, a fim de superar uma estética centrada no autor. Pensando a experiência estética em Corpo de Baile– projeto literário múltiplo, cuja configuração temática e formal ainda se discute- com fundamentação na tríade aishesis, poesis e katharsis, não se visa somente examinar a recepção crítica de Guimarães Rosa, mas, sobretudo, se coloca a questão da dimensão estética. PALAVRAS- CHAVE: Guimarães Rosa, Corpo de Baile, Recepção crítica, Hermenêutica.
THE PIONEER CONTRIBUTION OF LUIZ MARCELLINO DE OLIVEIRA TO EXPERIMENTAL ANALYSIS OF BEHAVIOR AND PSYCHONIOLOGICAL INVESTIGATION IN BRAZIL
Authors: Ferrari Elenice A. de Moraes
Published: August 2016

Luiz Marcellino de Oliveira (1939-2008) had an influential participation in almost every moment of the history of the Department of Psychology and Education, FFCLRP, as well as at different moments of the history of the Brazilian Psychology. This paper examines issues related to his pioneer work as a teacher of experimental analysis of behavior and as a psychobiological investigator in Brazil. Emphasis is given to his dedication to the development of science and to the consolidation of a scientific approach to Psychology in Brazil at the level of teaching and of experimental investigation. He contributed with investigations on the effects of drugs and malnourishment on behavior and brain development, conducting experimental analysis of behavior and neurochemical and electrophysiological analysis of the nervous system of the malnourished organism, as well as putting emphasis on environmental stimulation as a valuable intervention. Both as a teacher and as a researcher he exerted a prime influence on numerous professionals and members of the academic community that during more than forty years had the privilege of benefiting from his friendship and knowledge. Keywords: Luiz Marcellino de Oliveira; experimental analysis of behavior; psychobiology; malnutrition; environmental stimulation.