bluuebunny/crossref_metadata_2025 huggingface dataset:
Informasi Akuntansi Terkait Profitabilitas dan Biaya Monitoring untuk Keputusan Investor Perusahaan Healthcare dan Food and Beverage di Masa Pandemi Covid - 19
Authors: Miati  Hana Pertiwi  , Aisyaturrahmi
Published: February 2025

This research was conducted with the aim of determining the effect of ROA (Return On Asset) and NPM (Net Profit Margin) on stock price with capital structure as an intervening variable with the aim of providing accounting information to investors in making stock price buying and selling decisions. In this study, the population used was companies in the Healthcare sector and the Food and Beverage sub-sector registered on the IDX in 2020-2022. To test the hypothesis in this study, Multiple Regression Analysis was used and continued with Path Analysis to test intervening variables.The research results show that partial ROA has a negative influence on capital structure, while partial NPM has no influence on capital structure. In the second equation, ROA partially has a positive influence on stock price, NPM has a positive influence on stock price and capital structure has a negative influence on stock price. Indirectly, ROA has a significant effect on stock price through capital structure as an intervening variable, while indirectly NPM has no significant effect on stock price through capital structure as an intervening variable.
Pengaruh Kepemilikan Manajerial, Kepemilikan Institusional, Kepemilikan Asing, dan Kepemilikan Keluarga terhadap Penghindaran Pajak
Authors: Evi Nurjana Mujid  , Rochmad Bayu Utomo
Published: February 2025

The aim of this research is to determine whether managerial ownership, institutional ownership, foreign ownership and family ownership have an influence on tax avoidance. The population used in this research is all manufacturing companies listed on the Indonesia Stock Exchange in the 2013-2022 period. Using purposive sampling techniques, this research obtained 12 companies as research samples. The analytical method used in this research is multiple linear regression analysis, using SPSS. The results of this study show that managerial ownership, institutional ownership, and foreign ownership do not influence management activities in tax avoidance, while family ownership influences management activities in tax avoidance. The research employs publicly disclosed financial statement data, which may lack accuracy or completeness, data cleaning is performed using oulier elimination techniques, potentially excluding relevant insights and influencing the analysis outcomes. Future research is recommended to incorporate additional data, such as audited tax report, conduct comparative analysis of financial statement data across multiple years to detect consistent patterns, and utilize alternative calculation indicators to identify tax avoidance activities.
Pengaruh Corporate Governance Perception Index Terhadap Tingkat Financial Distress
Authors: Mayang Murni  , Lily Karlina Nasution
Published: February 2025

Banking companies have a role as an intermediary institution because of the foundation in building a country's economy. Banking companies that implement good Corporate Governance practices tend to be free from bad things like financial distress. This research aims to observe the influence of Corporate Governance Perception Index on Level of Financial Distress in BUMN Banking Companies form 2018-2023. . The data used is secondary data from the financial reports of state-owned banking companies and was analyzed using linear regressions. The result showed that Corporate Governance Perception Index has a influence on Financial Distress with a value that tend to small 5,9% with a minus contant, its means that the effect of implementing good Good Corporate Governance does not greatly affect the level of Financial Distress in BUMN Banking Companies in Indonesia. This is a limitation in the study, namely the object of research on BUMN companies in Indonesia, where the majority of ownership by the Government so that control and assurance of the continuity of a company depends on Government policies and public interests, so as not to worry about things like the level of financial distress. Based on the limitations, one suggestion that can be given is to replace the object of research on private companies included in the ranking of the Indonesian Institute for Corporate Governance or the ASEAN Corporate Governance Scorecard, as well as adding other fundamental indicators in assessing the level of Financial Distress
Rasio Lingkar Pinggang Panggul, Asupan Serat, Betakaroten dengan Kadar Gula Darah: A Cross Sectional Study
Authors: Tanuwijaya Rani Rahmasari , Hutabarat Setyowati Erineta , Manggabarani Saskiyanto
Published: February 2025

Pendahuluan: Diabetes Melitus merupakan kondisi dimana tubuh seseorang memiliki kadar gula darah yang melebihi batas normal. Faktor yang mempengaruhi diabetes melitus salah satunya adalah, asupan makan dan kelebihan berat badan. Konsumsi lemak yang tinggi dapat meningkatkan rasio lingkar pinggang panggul yang selanjutnya berhubungan dengan kadar gula darah. Asupan serat dan betakaroten yang baik juga mempengaruhi penurunan kadar gula darah.Tujuan: Menganalisis hubungan antara rasio lingkar pinggang panggul, asupan serat dan asupan betakaroten dengan kadar gula darah pada Guru Sekolah Dasar. Metode dan Sampel; Desain penelitian ini adalah cross sectional. Sampel yang digunakan berjumlah 120 guru di wilayah kecamatan Cilandak. Teknik pengambilan menggunakan purposive sampling dengan kriteria inklusi adalah guru SD yang bekerja di wilayah kecamatan Cilandak, berusia 25-60 tahun, bersedia menjadi responden dan tidak berpuasa. Adapun kriteria eksklusi yaitu responden tidak menyetujui untuk berpartisipasi, memiliki riwayat penyakit diabetes melitus, serta mengonsumsi obat penurun kadar glukosa darah. Variabel dalam penelitian ini adalah rasio lingkar pinggang panggul, asupan serat dan betakaroten serta kadar gula darah yang diuji menggunakan uji korelasi spearman. Hasil: Sebanyak 68% responden memiliki rasio lingkar pinggang panggul tidak normal. Sebagian besar responden memiliki asupan serat yang kurang kurang yaitu sebesar 88%. Sebanyak 92% responden memiliki asupan betakaroten yang kurang. Sebesar 100% responden memiliki kadar gula darah sewaktu normal. Hasil uji korelasi spearman menunjukkan rasio lingkar pinggang panggul (p=0,098), asupan serat (p=0,245), asupan betakaroten (p=0,392) dengan kadar gula darah. Kesimpulan: Tidak terdapat hubungan antara rasio lingkar pinggang panggul, asupan serat, dan betakaroten dengan kadar gula darah.Kata Kunci: Betakaroten, Serat, Kadar Gula Darah, Rasio Lingkar Pinggang Panggul.
INDICATORS OF THE FUNCTIONS OF THE HEPATOBILIARY SYSTEM IN PATIENTS WITH CHRONIC OPISTHROCHISIS WITH GENETIC PREDISPOSITION TO THE DEVELOPMENT OF ARTERIAL HYPERTENSION
Authors:   Tyumen Infection Pathology Research Institute, Bakshtanovskaya I.V. , Stepanova K.B. ,   Tyumen Infection Pathology Research Institute, Stepanova T.F. ,   Tyumen Infection Pathology Research Institute, Ozerova A.N. ,   Tyumen Infection Pathology Research Institute, Zmatrakova E.A. ,   Tyumen Infection Pathology Research Institute
Published: February 2025

To assess the influence of genetic features associated with the development of arterial hypertension on the reactivity of the hepatobiliary system in opisthorchiasis invasion, a study of biochemical parameters was conducted in subgroups of patients with chronic opisthorchiasis with and without mutations in loci associated with a predisposition to this disease. It was found that the presence of a mutation in the rs1042713 locus of the ADRB2 gene increases deviations in ALP activity from the level of healthy individuals caused by opisthorchiasis invasion and slows down the normalization of ALT activity, but accelerates the decrease in cholesterol levels after treatment. Similar effects on ALP activity and ALT reaction after treatment are exerted by the AGT rs4762 polymorphism. The effect of another polymorphism of the same gene (AGT rs699) in CO seems to be rather positive: lower values of GGT activity and a decrease in ALT activity and cholesterol levels in response to therapy indicate less damage and faster normalization of hepatocyte functions. In the presence of the mutant allele of AGTR1 rs5186, liver dysfunctions in chronic opisthorchiasis are apparently aggravated (ALT activity and bilirubin levels are higher, alkaline phosphatase activity increases after treatment, although the bilirubin level decreases at this stage). The presence of a rare allele in the rs1799983 locus of the NOS3 gene in patients with opisthorchiasis prevents an increase in AM activity, but slows down the normalization of ALT and GGT activity after treatment. The effects of the studied polymorphisms on the process of changing biochemical parameters during therapy do not allow us to draw unambiguous conclusions, but may indicate a predominantly positive effect on the state of the hepatobiliary system in chronic opisthorchiasis of mutations in the AGT rs699 and NOS3 rs1799983 loci, and a predominantly negative effect in the ARDB2 rs1042713, AGT rs4762 and AGTR1 rs5186 loci.
METHODS OF DIAGNOSTICS AND TREATMENT OF PARASITOSES WITH UNPROVEN EFFECTIVENESS AS A THREAT TO THE BIOSAFETY OF RUSSIA
Authors:   FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation (Sechenov University), Moscow, Russian Federation, Ismailov M.-M.M. , Morozova L.F. ,   FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation (Sechenov University), Moscow, Russian Federation, Anikina A.S. ,   FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation (Sechenov University), Moscow, Russian Federation, Roshchin D.O. ,   Federal State Budgetary Institution “National Research Institute of the Public Health named after N.A. Semashko”, Moscow, Russian Federation, Sigidaev A.S. ,   FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation (Sechenov University), Moscow, Russian Federation, Algulian A.D. ,   FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation (Sechenov University), Moscow, Russian Federation, Morozov E.N. ,   FSAE Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russian Federation (Sechenov University), Moscow, Russian Federation
Published: February 2025

Development and improvement of modern methods of diagnostics of infectious and parasitic diseases remains one of the most priority directions of medical science development in modern conditions. The situation is complicated by the emergence of treatment and prevention institutions in the field of parasitology, practicing diagnostic methods with unproven effectiveness, such as diagnosis by Dr. Voll, iridodiagnostics, bioresonance diagnostics, etc., leading to incorrect diagnosis and, consequently, ineffective treatment. This study is devoted to assess the clinical relevance of such methods, current status and possible future directions. 3254 outpatient parasitological admission charts from 2016-2024 were analyzed.
The study showed that more than half of the patients (63.2%) who came to the initial parasitologist appointment had previously used methods of diagnosis and treatment of parasitic diseases with unproven efficacy, 56% of these patients developed parasitic phobias and other somatoform disorders.
The clinical relevance of diagnostic and treatment methods with unproven efficacy remains a challenge for the medical community. The consequences of such use may have an impact on the entire system of domestic healthcare, as it is directly related to patient safety, healthcare costs and quality of healthcare delivery.
DETERMINATION OF INSECTICIDAL EFFICIENCY OF AQUEOUS EMULSION OF TETRAMETRIN AGAINST MELOPHAGUS OVINUS (INSECTA: DIPTERA: HIPPOBOSCIDAE)
Authors:   Federal State Budgetary Educational Institution of Higher Education “Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K.I. Skryabin”, Moscow, Akbayev R.M. , Generalov A.A. ,   Limited Liability Company “Clean World”, Moscow
Published: February 2025

n this research paper, we describe the results of experiments aimed at determining the insecticidal efficiency of aqueous emulsions of a synthetic pyrethroid with the active substance 5% tetramethrin EC against sheep bloodsuckers of the Melophagus ovinus species in vitro. As a result of the experiments, we found a fairly high efficiency of the insecticide at low concentrations. In addition, when examining the livestock of sheep in the private sector located in the Karachay-Cherkess Republic, melophagosis was diagnosed in all animals, which corresponds to 100% extensiveness of the invasion.
SOME EPIGENETIC ASPECTS OF THE MECHANISMS OF ANTIGENIC VARIABILITY OF MALARIAL PARASITES
Authors:   Moscow, Sakharova T.V. ,   Sechenov First Moscow State Medical Univesity, Department of Biology and General Genetics, Larina S.N. ,   Moscow; Sechenov First Moscow State Medical Univesity, Department of Biology and General Genetics, Rakova V.M. ,   Federal State Budgetary Educational Institution ofHigher Education “Moscow state Academy of Veterinary Medicine and Biotechnology- MVA by K.I. Skryabin”,   RMA of Continuous Professional Education, Poluektova V.B. ,   Moscow; Sechenov First Moscow State Medical Univesity, Department of Biology and General Genetics, Ivanova E.D. ,   Moscow; Sechenov First Moscow State Medical Univesity, Department of Biology and General Genetics, Malin S.S. ,   Moscow; Sechenov First Moscow State Medical Univesity, Department of Biology and General Genetics, Shidlovskii Y.V. ,   Moscow; Sechenov First Moscow State Medical Univesity, Department of Biology and General Genetics, Chebyshev N.V. ,   Moscow; Sechenov First Moscow State Medical Univesity, Department of Biology and General Genetics
Published: February 2025

The article presents current data on the study of genetic adaptations in the parasite-host system in human malaria. In particular, the work is devoted to the analysis of some epigenetic mechanisms of antigenic variability of plasmodia, that ensure their survival and adaptation in the host organism. Understanding of these mechanisms may provide insights into the development of new strategies for the treatment and prevention of malaria.
ON THE QUESTION OF THE NECESSITY TO DEVELOP AN ORDER ON THE PROCEDURE FOR PROVIDING MEDICAL CARE IN PARASITOLOGY
Authors:   Federal State Budgetary Institution “National Research Institute of the Public Health named after N.A.Semashko”, Moscow, Russian Federation, Roshchin D.O.
Published: February 2025

The article provides an analysis of modern regulatory regulation of the activities of a parasitologist in a medical organization (within the framework of laboratory diagnostics, and, first of all, patient treatment). It has been established that this issue is practically not covered by the provisions of regulatory legal acts in the Russian Federation, at the same time, parasitologists provide consultations in outpatient settings, and this service is in demand from a market point of view. The regulatory enactment of a procedure for the provision of medical care in parasitology is expected to make it possible to establish the routing and phasing of medical care for patients, and to determine the interaction and detail the work function of a parasitologist in a medical organization.
Predicting the geofiltration processes within the closed quarry zone in difficult technogenically disturbed conditions
Authors: Sherstiuk Ye. A , Petlovanyi M. V , Sai K. S
Published: February 2025

Purpose. The research purpose is a predictive assessment of the water content of the mined-out quarry cavity under conditions of simultaneous technogenic impact of active quarries and mines based on numerical modeling of geofiltration processes to determine the probability of contact and water saturation of the formed backfill mass over time.

Methodology. A numerical geofiltration model implemented in the MODFLOW software package is used to study the hydrodynamic regime of a specified site in the Kryvyi Rih region, where a closed quarry is located, planned for backfilling. The solution of inverse and prognostic problems is applied, in the course of which the adequacy of reflecting the hydrodynamic conditions of the studied area in the geofiltration model has been determined, as well as the predicted rates and nature of the level restoration at the mining site have been obtained.

Findings. A complex model of geofiltration processes has been developed and tested, taking into account the technogenic impact of operating quarry and mines, which makes it possible to assess the nature of groundwater level restoration in dynamics. It has been found that in the current situation of the hydrodynamic groundwater regime at the site, the greatest impact is caused by drainage dewatering of mines, which has led to the formation of depression cones and groundwater discharge in a large active quarry and a closed quarry planned for backfilling. It has been determined that if the drainage dewatering of all mining enterprises is completely stopped, which is unlikely, the groundwater level restoration in a closed quarry can occur no earlier than in 50 years, while the dependence of the groundwater level restoration over time is logarithmic.

Originality. Based on the modeling of geofiltration processes, an assessment of the groundwater level restoration in a closed quarry is provided during the development of various scenarios for the cessation of dewatering at mining enterprises that have a significant technogenic impact on the hydrodynamic regime. It has been proven that when backfilling the mined-out space of a closed quarry, a monolithic backfill mass will not be prone to a decrease in physical-mechanical characteristics from the influence of aquifers, which will ensure its long-term geomechanical reliability.

Practical value. A methodology has been developed for modeling geofiltration processes and restoring the groundwater level of a closed quarry, taking into account the difficult complex technogenic impact of various mining enterprises. The results obtained are important for the predictive assessment of the probability of water saturation of the backfill mass in the quarry cavity and planning of engineering-geological measures for its isolation.
Study of the effectiveness of extinguishing model fires of coniferous and deciduous wood
Authors: Renkas A. A , Popovych V. V , Pasnak I. V , Tovarianskyi V. I
Published: February 2025

Purpose. Establishing the feasibility of using the FDS computer model to determine the specific consumption rate of finely sprayed water for extinguishing wood as an alternative to physical modeling.

Methodology. The study utilized the functionality of the Fire Dynamics Simulator (FDS) computer model; a methodology for determining the consumption and volume of extinguishing agents for extinguishing model fires of type 1A for various wood species within a specially designed testing ground for experimental fire tests; the results of the research were processed using Microsoft Excel.

Findings. According to the results of computer modeling, it was established that for the combustion of selected wood species over a duration of 0–180 seconds, the highest temperature in the fire center occurs for fir at 173 seconds, reaching 1,180 °C. The peak temperature in the combustion environment for common pine is observed at 170 seconds, measuring 1,165 °C. The temperatures for silver birch and common oak were lower, at 1,000 °C (178 seconds) and 855 °C (173 seconds), respectively. After applying finely sprayed water to the fire center of the model fires made of pine and fir, the temperature decreased below the ignition point after 57 seconds, with a water consumption rate of 2 l/s. For the extinguishing of model fires made of oak and birch, the extinguishing effect was observed at 135 and 105 seconds, respectively. Based on the conducted research, the specific consumption rates of finely sprayed water for extinguishing common oak and common pine were determined to be 168 and 120 l/m³, respectively.

Originality. For the first time, the Fire Dynamics Simulator (FDS) computer model was used to simulate the extinguishing process for four of the most common types of forests – common pine, Douglas fir, silver birch, and common oak. It was established that when extinguishing fires in coniferous wood species with a finely sprayed water consumption rate of 2 l/s, the extinguishing effect is achieved at 57 seconds.

Practical value. The conducted computer modeling and experimental field studies allowed for the determination of the calculated amount of finely sprayed water needed for extinguishing fires in various wood species. The specific consumption rates of extinguishing agents for fighting fires in coniferous and deciduous wood species can be used for calculating the forces and resources required for firefighting in forested areas.
Depression, anxiety and stress assessment in women with polycystic ovary syndrome attending a tertiary care hospital in Bangladesh
Authors: Haseen Fariha , Selim Shahjada , Kazal Rezaul Karim , Ahsan Mohammad Shamsul , Akter Nurjahan , Hedayet Hridi , Haney Umme , Nasrin Begum , Islam Syed Shariful
Published: February 2025

Background: This study evaluated depression, anxiety, and stress in women with polycystic ovary syndrome (PCOS) using the depression, anxiety, and stress scale-21 (DASS-21) and examined their live experiences with this endocrine disorder.
Methods: A mixed-methods study, combining an analytical cross-sectional study and qualitative grounded theory, was conducted from February to June 2022 at Bangabandhu Sheikh Mujib Medical University. The study involved 266 pre-diagnosed women with PCOS. Psychological symptoms were assessed using the DASS-21. Additionally, 10 in-depth patient interviews and 6 key-informant interviews with mothers explored the personal and societal dynamics of PCOS.
Results: The survey revealed significant psychological distress among participants, with 32% as "moderate" for depression, 68% as "extremely severe" for anxiety, and 45% as "severe" for stress. Participants had a mean age of 24.2 years (standard deviation 5.4) and were pre-diagnosed cases of PCOS. Married women had higher odds of anxiety (OR 2.0; 95% CI 1.1‒3.2), while menstrual problems predicted both anxiety (OR 2.0; 95% CI 1.0‒3.4) and stress (OR 2.0; 95% CI 1.0‒3.4). Insomnia significantly predicted anxiety (OR 3.0; 95% CI 1.4‒6.2) and stress (OR 2.3; 95% CI 1.1‒5.1). Societal stigma compounded these challenges, with unmarried girls concerned about acne and hirsutism, and their mothers focusing on menstrual irregularities and fertility. Married women delayed care-seeking by 2–3 years, driven by infertility concerns, highlighting societal pressures around marriage and childbearing as more significant stressors than PCOS itself.
Conclusion: Women with PCOS face significant mental health challenges which are exacerbated by marital status, insomnia, menstrual issues, and societal stigma. Family support plays a role in coping with the condition.
The Level of Cortisol In the Oral Fluid In Patients with Generalized Periodontitis with Manifestations of Anxiety
Authors:   National Medical University named after A.A. Bogomoltsa, Kyiv, Ukraine, Horodnov Ye.
Published: February 2025

Actuality. The prevalence of periodontal tissue diseases among the adult population of working age from 35 to 55 years is quite high.
It has no tendency to decrease, which makes this problem extremely urgent. Psychoemotional attitude to pain, negative experience
of previous treatment, and the patientfs dental anxiety prevent visits to the clinic for a long time, which exacerbates inflammation and
complicates the treatment of patients with generalized periodontitis with manifestations of anxiety.
Purpose. Analyze the level of cortisol in oral fluid in patients with generalized periodontitis, with manifestations of anxiety before and
after treatment.
Research materials and methods. A study of the cortisol level was conducted in 157 patients with generalized periodontitis with
manifestations of anxiety, aged 35.55 years, and the gender composition of patients.men (28.7%) and women (71.3%). Patients are
divided into three groups. The examination was carried out before and after treatment.
Research results. It was found that the level of cortisol in the oral fluid increases in patients with generalized periodontitis in those
groups with an increased or high level of anxiety. Before treatment, a significant increase in cortisol in the oral fluid was found in groups
HP-T1 with a moderate level of anxiety and in groups HP-T2 with a high level of anxiety found a significant increase in cortisol in the oral
fluid. After the medical and preventive measures, the cortisol levels decreased. In particular, in the 35.44 age group, at 10:00 a.m., the
cortisol level decreased from 3.02 } 1.87 ng/ml to 2.52 } 1.57 ng/ml. According to Fisherfs test, it is significantly correlated (p . 0.05) with
the group results. In the age group of 45.55 years old treatment, the cortisol level was 3.71 } 1.9 ng/ml. After treatment, it decreased
to 2.77 } 1.5 ng/ml, which also correlates with the results by group (p . 0.05) according to Fisherfs test. The indicators did not change
significantly in the control group. Thus, an increase in the level of inflammation of the periodontal tissues in generalized periodontitis
and an increase in the level of anxiety increases the cortisol level in saliva. After the treatment, the results in the groups significantly
changed, which was statistically significantly (p < 0.05) different from the indicators of the control group.
Conclusions. Oral fluid cortisol testing is a convenient, noninvasive method for assessing anxiety levels in patients. Comprehensive
treatment and corrective and preventive measures for patients with generalized periodontitis who manifested anxiety brought the
cortisol level closer to the reference values.
Keywords: generalized periodontitis, dental anxiety, stress, cortisone, treatment, prevention, correction.
ПІДВИЩЕННЯ ЕКОНОМІЧНОСТІ РОБОТИ СУДНОВИХ СЕРЕДНЬООБЕРТОВИХ ДИЗЕЛІВ
Authors: Сагін А.С. , Заблоцький Ю.В. , Сагін С.В.
Published: February 2025

Надані результати досліджень, щодо визначення впливу паливних присадок на економічні показники роботи суднових дизелів. Експерименти виконувались на судні класу Containershipнеобмеженого району плавання, здатного для перевезення 9850 TEU-контейнерів (до 620 з яких –рефрижераторні). Дослідження виконувались на чотирьох однотипних суднових дизелях Wartsila6L32, що використовувались як допоміжні дизель-генераторів. Дизелі експлуатувались на дистилятних паливах DMA20 (зі вмістом сірки 0,077% за масою) та RMG450 (зі вмістом сірки 0,46% за масою). У разі знаходження судна у спеціальних екологічних районах експлуатація дизелів виконувалася на паливі DMA20, під час знаходження судна поза цих районів –на паливі RMG450.Як паливні присадки використовувались продукти фірми DrewMarine: Amergy1000, Amergizeта AmergyXLSPlus. В трьох дизелях Wartsila6L32 використовувалась паливна суміш, яка складалась з палива нафтового походження (RMG450 або DMA20) та паливної присадки Amergy1000, паливна суміш з RMG450 або DMA20та паливної присадки Amergize, з RMG450 або DMA20та паливної присадки AmergyXLSPlus. Саме на цих дизелях виконувались експериментальні дослідження з визначення ефективності використання біодизельного палива FAME. Один з дизелів експлуатувався виключно на паливі RMG450 або DMA20, без використання паливної присадки. Під час проведення експериментальних досліджень дизелі Wartsila6L32експлуатувалися рівні проміжки часу на важкому паливі RMG450 або DMA20 з різними паливними присадками Amergy1000, Amergizeта AmergyXLSPlus. При цьому їх експлуатація виконувалась на навантаженнях 50%, 60%, 70%, 80% від номінальної потужності. Тривалість проведення експерименту на кожному з навантажень становила 1...3години і залежала від умов плавання судна. Метою першого етапу дослідження було визначення з вказаних присадок такої, яка сприяє найкращої економічності роботи дизеля –а саме забезпечуємінімальну питому витрату палива. Як така присадка булі визначена паливна присадка AmergyXLS. Завданням другого етапу було визначення оптимальної концентрації присадки в паливі. Це дало можливість визначити концентрацію, яка забезпечує мінімальну питому витрату палива, що сприяє підвищенню економічності роботи суднових середньообертових дизелів
Ключові слова: дистилятне паливо, економічність роботи, морський транспорт, паливна присадка, концентрація, питома витрата палива, судновий дизель-генератор, судновий середньо обертовий дизель
Reduction Glossectomy in a 3-Month-Old Female Infant With Beckwith-Wiedemann Syndrome
Authors: Kim Gangmi , Oh Subi , Kim Younghac , Choi Nayeon
Published: February 2025

Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth disorder presenting with various clinical manifestations, including macroglossia, visceromegaly, gigantism, neonatal hypoglycemia, and anterior abdominal wall defects. Most patients with BWS suffer from swallowing and respiratory difficulty due to macroglossia, which requires surgical intervention. However, the tongue has a complex neuromuscular anatomy which is closely related to swallowing, phonation, and respiration. Therefore, care should be taken when performing reduction glossectomy for BWS patients to minimize complication after surgery. This case report describes a successful surgical intervention for macroglossia in a 3-month-old female infant diagnosed with BWS, who presented respiratory and swallowing difficulty. The keyhole shape glossectomy was performed and the patient was orally fed without respiratory difficulty 3 weeks following the surgery.
Frontal Sinus Stenting in Endoscopic Sinus Surgery
Authors: Chung Jaein , Kim Yong Min
Published: February 2025

In frontal sinus surgery, stenosis of the frontal sinus opening after surgery remains a challenge for many surgeons. Different surgical approaches such as Lynch procedure, Draf type II, and extended modified Lothrop procedure may decrease adverse surgical results but also accompany inherent complications. The use of various kinds of stents have been also suggested to prolong the patency of the frontal sinus opening. However, no definite consensus has been reached about frontal stents use. Here we introduce the experience of using a new omega shaped silicon stent, which has shown promising results in keeping the frontal sinus opening patent.
NEVER WASTE A GOOD CRISIS
Authors:   , de Bruin Odette
Published: February 2025

The COVID-19 pandemic, declared in March 2020, significantly disrupted healthcare systems globally, with pregnant women facing heightened risks of severe illness. However, these women were largely excluded from clinical trials assessing COVID-19 treatments and vaccines, which exacerbated gaps in knowledge about medication safety during pregnancy. Despite growing awareness of the importance of including pregnant women in medical research, less than 5% of medications provide safety data for pregnancy, and less than 1% of clinical trials include pregnant participants. This dissertation focuses on the safety of COVID-19-related medications and vaccines during pregnancy, with an emphasis on real-world evidence (RWE) as a critical resource for filling these research gaps.

One of the key findings is the low usage of COVID-19 treatments among pregnant women, even in severe cases. Many hospitalized pregnant women did not receive the appropriate medical treatment, which likely contributed to an increased risk of adverse outcomes such as preterm birth and cesarean sections. These findings underscore the need for clear treatment guidelines and better access to medication during pandemics.

The research also highlights the significant challenges around maternal vaccination. Despite the proven benefits of vaccines in protecting both mothers and newborns, vaccine hesitancy remains widespread among pregnant women, often driven by safety concerns. While limited randomized clinical trials (RCTs) exist, real-world data increasingly suggests that maternal vaccines are both safe and effective, though concerns about fetal safety persist and require further investigation.

This dissertation emphasizes the importance of international collaborations and RWE in advancing maternal health research. Initiatives such as the Innovative Medicines Initiative (IMI)-funded ConcePTION and the International Network of Obstetrics Survey Systems (INOSS) have facilitated large-scale data collection, providing valuable insights into medication use and pregnancy outcomes. These networks were instrumental in providing evidence during the pandemic and must be sustained to ensure continuous progress in understanding medication safety for pregnant women.

In conclusion, the COVID-19 pandemic revealed significant gaps in research regarding medication safety during pregnancy, but also presented an opportunity to advance global collaboration and RWE. Moving forward, it is crucial to maintain and expand these research infrastructures, focusing on investigating the safety of commonly used medications during pregnancy. This requires ongoing international collaboration, harmonized data collection, and continued investment in real-world data, ultimately supporting better-informed decision-making for healthcare providers and pregnant women.
Uji Aktivitas Antikoagulan pada Sel Darah Manusia dari Ekstrak Bawang Bombai (Allium cepa L.)
Authors: Febriani Fany , Hardy Junius , Riskianto
Published: February 2025

Thromboembolic disorders can cause various life-threatening cardiovascular diseases. Anticoagulants are the most common treatment for thromboembolic disorders. Organosulfur compounds in onions, such as allicin and flavonoid compounds, have anticoagulant properties. The purpose of this study is to test the anticoagulant activity of onions extracted by maceration method using 96% ethanol as a solvent. The anticoagulant test was performed on samples of blood groups A, B, AB, and O using the Lee-White method. Six tubes were filled with 1 cc of each blood sample with treatments including control (without treatment), negative control (96% ethanol), positive control (EDTA), and variation of extract concentrations 5; 7.5; 10%. The results of 96% ethanol extract of Onion (Allium cepa Linnaeus) using the maceration method contains secondary metabolites including flavonoids, saponins, and phenols. The onion extract had a significant mean difference (p < 0.05) with the EDTA positive control group and did not produce a significant mean difference (p > 0.05) with the untreated group, so the onion extract with a concentration of 5; 7.5; 10% extracted with 96% ethanol solvent using maceration method had no anticoagulant activity. Blood type A, B, AB, and O did not have a significant difference in the mean blood clotting time with a value of P = 0.504 (p > 0.05).
Efektivitas Virtual Laboratory Dibandingkan Real Laboratory pada Perkuliahan Hybrid terhadap Kemampuan Berpikir Kritis Mahasiswa
Authors: Nilam Tyas Dewi , Isdaryanti Barokah , Agry Feylosofia Putri
Published: February 2025

Students have the opportunity to carry out Biology practicums through real laboratories in labs and virtual laboratories during post-pandemic hybrid lectures. In this regard, this study aims to compare the effectiveness of real laboratory and virtual laboratory and compare the effectiveness of both through hybrid lectures in improving the critical thinking skills of elementary school teacher education students at Universitas Negeri Semarang. This type of research is a quasi-experimental study with a control group pretest-post-test design. The population in this study were second-semester students taking science laboratory courses, with a sample of 94 students. The research will be carried out at the elementary school teacher education campus, Universitas Negeri Semarang, Central Java in April-June 2022. Biology practicum activities using real laboratories as opposed to using virtual laboratories show that virtual laboratories and real laboratories are effective in improving critical thinking skills. The N-gain score in the virtual laboratory group was 0.4494 (medium) and the N-gain score in the real laboratory group was 0.4867 (moderate). Even though the N-gain is in the moderate category, the score is higher in the real laboratory, so it is concluded that the real laboratory is more effective for increasing critical thinking skills through hybrid lectures.
Studi Keanekaragaman Invertebrata Di Kawasan Perairan Teluk Maumere Nusa Tenggara Timur
Authors: Arafah Sitti , Juniyati Hastuti
Published: February 2025

The research objective was to determine the diversity of invertebrates in the waters of Maumere Bay, East Nusa Tenggara. This research was conducted in July-August using an exploratory descriptive approach. Sampling using purposive sampling technique. The results of the study found 150 species with descriptions: 26 species of Porifera phylum, 22 Coelenterata phylum, 67 Mollusca phylum, 5 Arthropoda phylum, and 30 Echinodermata phylum. Ecological parameters: Invertebrate density 2.05/m2-0.227/m2, relative density (RD) 0.017-0.001. The highest density value was from the type of Conus teselatus and the lowest density was from the type Aphrocallistes vastus. Frequency 0.017-0.001, relative frequency (RF) 0.015-0.001 with the highest frequency value of the Conus tesulatus type and the lowest frequency of the Aphrocallistes vastus type. The highest Importance Value Index for Conus tesulatus is 0.033 and the lowest for Aphrocallistes vastus is 0.002. The Shannon-Wiener species diversity index (H') value is 784,562 or the high richness category and the evenness value (E) is 77,856 which means that quantitatively the density value among community members is evenly distributed (E passes 1). The distribution pattern of all types of invertebrates is grouped with a Morisita Index (IM) value of 11.46-38.78 or an IM value > 1. The diversity of invertebrates in the study area is strongly influenced by environmental factors such as temperature, pH, salinity, and substrate which can reflect good conditions for the growth of invertebrates.
Keanekaragaman Hama Dominan pada Tanaman Padi (Oryza sativa L.) Di Langsa Timur, Aceh
Authors: Nurjannah  , Isnijar Wahyu Firmana , Salwa Zakia Hanifah , Sari Herlina Putri Endah , Purnamawati Jatu
Published: February 2025

Oryza sativa L. is a rice-producing food commodity plant that has high economic value, because of its function as staple food, source of income and source of nutrition for most of Indonesia's population. The availability of rice must always be guaranteed, but often encounters obstacles, one of which is the presence of pests. The purpose of this study was to determine the diversity and dominant pests species on rice plants in 3 villages, i.e Sukarejo, Alue Pineung and Cinta Raja Village, East Langsa District, Aceh. The method used in this research is descriptive explorative field observation using hand collecting sampling. Data analysis was carried out by describing pests, symptoms of attack and continued by calculating the value of the Shannon-Wiener diversity index. Based on the observations, the result showed 6 species of pests were found on rice which consist of 5 orders and 6 families, they are Leptocorisa acuta, Nezara viridula, Oxya serville, Lonchura leucogastroides and Pomacea caniculata. The diversity index values ​​in 3 villages were 1.41-1.72 with highest diversity index value from Alue Pineung Village. Of the 6 types of species, the dominant pest causing the most damage was Leptocorisa acuta (Walang sangit). This research is expected to be a reference in preventing pest attacks in the Langsa.
Keywords: Diversity of pests, dominant pests, rice
KOMPOSISI NUTRIEN SAMPAH ORGANIK SISA NASI DAN TULANG IKAN NILA DAN PENGARUHNYA BAGI PERTUMBUHAN LARVA BLACK SOLDIER FLY (Hermetia illucens L.)
Authors: Abrillian Albert , Aditiyarini Dwi , Madyaningrana Kukuh
Published: February 2025

Sampah organik sebagai hasil sampingan aktivitas rumah tangga yang diproduksi secara kontinyu masih menjadi isu utama permasalahan di Indonesia. Pengelolaan sampah organik secara konvensional masih didapati kelemahan dan batasan. Larva lalat tentara hitam merupakan dekomposer yang dapat dimanfaatkan dalam pengelolaan sampah organik. Penelitian ini bertujuan untuk mengukur kadar nutrien sampah organik yang digunakan, seperti sisa nasi, tulang ikan nila, maupun gabungan keduanya dan mempelajari penggunaan sampah organik tersebut bagi pertumbuhan larva BSF. Penelitian menggunakan 150 larva BSF berumur 12 hari dengan tiga kali ulangan dan empat perlakuan uji: pakan T51 (kontrol), sisa nasi, tulang ikan nila, dan kombinasi sisa nasi dan tulang ikan nila (50:50). Kadar karbohidrat dan lemak tertinggi masing-masing terdeteksi pada sisa nasi dan tulang ikan nila. Jenis pakan berdampak terhadap nutrien dan pertumbuhan larva BSF. Perlakuan kombinasi menghasilkan larva dengan biomassa terbesar dan waktu pertumbuhan tersingkat, disisi lain, perlakuan tunggal memperpanjang waktu pertumbuhan larva dengan biomassa yang cenderung kecil. Perlakuan kombinasi antara sisa nasi dan tulang ikan nila (50:50) merupakan jenis pakan terbaik dalam mendukung pertumbuhan larva BSF, sedangkan perlakuan pakan tunggal dinilai kurang tepat bagi pertumbuhan larva BSF
Analisis Respon Siswa terhadap Powerpoint Interaktif Materi Sistem Peredaran Darah Manusia Kelas VIII
Authors: Anduweni  , Yeni Laili Fitri , Ningsih Kurnia
Published: February 2025

This research was conducted to find out how students responded to interactive PowerPoint media on the human circulatory system material in class VIII of Kristen Immanuel II Sungai Raya Middle School. The research method in this research is quantitative descriptive. The sample in this study was 10 students in class VIII of Immanuel II Sungai Raya Christian Middle School. The population in this study were all students of the Christian Immanuel II Sungai Raya Middle School. The technique used was a simple random sampling technique with a lottery system. Data collection techniques in this research include interviews, observation and questionnaires. The overall average percentage of student responses to interactive PowerPoint media was 85.68% in the very positive category. the cognitive aspect obtained an average of 85.83% in the very positive category, the affection aspect 85.42% in the very positive category, the conation aspect 85.63% in the very positive category, and the overall average was 86% in the very positive category.
Aplikasi Asam Humat dan Pupuk Organik Cair Ekstrak Rumput Laut untuk Meningkatkan Pertumbuhan dan Kandungan Flavonoid Brassica juncea L.
Authors: Setiawati Tia , Fitria Sania Septiani , Nurzaman Mohamad , Hasan Rusdi , Mutaqin Asep Zainal , Lestari Ani
Published: February 2025

This research was conducted with the aim of obtaining the optimal dose of humic acid (HA) and liquid organic fertilizer (LOF) from seaweed extract that can enhance the growth and total flavonoid content of Brassica juncea L. The method used in this study was experimental with a randomized complete block design with two factors. The first factor was HA, consisting of 4 dose levels: 0, 4, 8, and 12 g/kg, while the second factor was LOF from seaweed extract, consisting of 4 dose levels: 0, 1, 2, and 3 mL/L. Each treatment was replicated four times. Parameters were observed on the 42nd day, including plant height, leaf number, leaf area, dry weight, and total flavonoids. Data were analyzed using Analysis of Variance (ANOVA) and followed by Duncan's Multiple Range Test with a confidence level of 95%. The results showed that the dose of 4 g/kg HA and 2 mL/L LOF was the best dose for enhancing growth and total flavonoid content, producing an average plant height of 19.25 cm, a leaf number of 5.75, a total leaf area of 179.8 cm2, a dry weight of 0.57 grams, and a total flavonoid content of 0.106 mg QE/g sample.
KARAKTERISASI VARIASI MORFOLOGI Youngia japonica (L.) DC. (ASTERACEAE) DARI PULAU SUMATERA, INDONESIA
Authors: Wakhidah Anisatu Z.
Published: February 2025

Youngia japonica (L.) DC. is perennial herb with yellow hermaphrodite flower. Based on herbarium collection from Herbarium Naturalis Biodiversity Centre (L), a variety was discovered from Japan in this species which named as Youngia japonica Benth var. acutiloba Miq. There are posibilites about discovering variety in herbarium collection of Youngia japonica (L.) DC. from Sumatera Island wich owned by Herbarium Bogoriense (BO). Fenetic analysis revealed that morphological character observation resulted 4 group with difference at some morphological characters in Youngia japonica (L.) DC herbarium. Those character were height of habit, stem surface, stipule, and leaf margin. Due to those character got great  influenced by environment factor, those character not yet satisfy to classify Youngia japonica (L.) DC. in taxon infra species. Beside it, there is an assumption that Youngia japonica (L.) DC. has a large variety morphology which because of its adaptation ability.
 
Keywords : herbarium, Sumatera, variety, Youngia japonica,
EKSPLORASI JENIS ROTAN DI KABUPATEN TIMOR TENGAH SELATAN, PROVINSI NUSA TENGGARA TIMUR
Authors: Kalima Titi , Malik Jamaludin , Sunarto Sunarto
Published: February 2025

South-Central Timor District with the area of â€‹â€‹3,955.36 km2 holds a lot of diversity of non-timber forest products, including rattan plants. Rattan is widely spread in forest area which is its natural habitat. The increasing of both legal and illegal forest exploitation and land conversion resulted in the habitat damage. Some communities around the forest have used rattan as raw material for plaits, ropes and household needs, while the rattan has not been inventoried and cultivated properly. The purpose of this study is to determine the diversity of rattan species and utilization by the people in the District of South-Central Timor, East Nusa Tenggara Province. Field research activities were carried out using the exploration method in the Kualeui forest area, namely the villages of Oelalali, Sub-District of Kualin and Lolli Village, Sub-District of Pollen. Rattan data collection was recorded in passport data followed by data documentation. Exploration results show that the forests of South-Central Timor Regency found three species of rattan consisting of two genera, namely Calamus and Daemonorops. In this district, rattan grows at the altitude of 100-1500 above sea level. The most commonly used rattan species by communities around the forest are Calamus timorensis Beccari and C. toli-toliensis Beccari ex Heyne, while Daemonorops melanochaetes Blume is not utilized. Therefore there is a need for further development of the utilised rattan.
 
Keywords: Exploration, Rattan, South-Central Timor District, Utilization.