bluuebunny/crossref_metadata_2025 huggingface dataset:
Seasonal assessment of pupal habitat productivity of malaria vector: Anopheles gambiae s.l as influence by physico-chemical conditions at selected breeding habitats in Niger, Nigeria
Authors: Babale Shitta Kefas , Salim Hasber , Yakudima Ismaila Ibrahim , Kabir Buda Mohammed , Mamman Rashidu , Chiroma Usman Mohammed , Ibrahim Shehu Kura
Published: May 2023

Malaria is the most significant protozoan disease in Africa and the principal vector-borne disease (VBD) in Nigeria, which is influenced by the quality of breeding habitats that are reflected through the stage preceding adult. Control of Anopheles gambiae s.l. populations through source reduction is still considered the most effective way of prevention and control, although it has proven unsustainable in Niger State. Physico-chemical cues were investigated. Samples were taken inside and outside 1m2 cages weekly by dipping and emptying the cages from May 2019 to March 2020. The data subjected to analysis of variance (one and two-way Anova). The findings revealed the mean pupae abundance (MPA), were significantly higher in Large Water bodies (624.50±217.81), and followed by Gutters (436.00±184.2) and Swamps (285.50±125.06). The mean pupae productivity (MPP), followed the order of descending rate >GT (717.50±219.38) >LW (677.21±145.10) >SW (530.40±136.97). The result also showed that emptying technique (ET) was more sufficient and reliable than dipping technique (DT). The peak abundance and productivity of the pupal stage was June to August then declined in March,2020 both habitats. However, MPP differed significantly (p<0.05) from one another across the months in all the habitat types. The physical and chemical cues of the breeding sites, varied significantly, except in temperature, total hardness, biochemical oxygen demands, conductivity, and pH in all the habitats. This study revealed high utilization of physico-chemical properties and poses increased risk of malaria. Thus, emphasis on the vector management strategies should be given specially on gutters and large water bodies as breeding habitats of malaria vectors (MV), in Niger State
Improvement of the manufacturing method of semi-finished fruit and vegetables of a high degree of readiness
Authors: Zahorulko Andrii , Zagorulko Aleksey , Postadzhiev Alexander , Ibaiev Eldar , Birchenko Nataliia , Tytarenko Nataliia
Published: May 2023

The method of production of concentrated fruit and vegeTable semi-finished product based on apples, Jerusalem artichoke and quince has been improved. Selected components of plant raw materials are chosen due to the presence of such useful substances as pectins, vitamins, minerals, etc. The obtained semi-finished products of a high degree of readiness are semi-finished products with a natural nutrient composition. A feature of the proposed method is the use of low-temperature modes of concentration and drying of raw materials. For the developed method, the hardware set of the line with the use of advanced thermal equipment was selected. Chopped raw materials are blanched in a universal multifunctional device: apple and Jerusalem artichoke in a steam environment (103 °C and 108 °C) for 4 and 8 minutes. Quince is blanched under conditions of pre-exposure in a 0.1 % solution of citric acid in an aqueous medium at a temperature of 75...80 °C (4...8 min.).

Concentration to a pasty state takes place in the improved design of the rotary-film apparatus with a reduced processing time of 0.75...1.25 s to a DM content of 28...30 %. To obtain a powdery state, a cylindrical IR dryer was used for drying to the final moisture content at the level of 4...6 % DM. It is also possible to dry the extracts formed after wiping the raw materials to a final moisture content of 10...13 % DM in an IR dryer. The use of low-temperature regimes in the range of 45...60 oC helps to obtain high-quality semi-finished products with maximum preservation of the initial properties of raw materials. By means of organoleptic evaluation, the best experimental sample with the content of blend components was found: apple 40 %; Jerusalem artichoke 35 %; quince 25 %. Developed semi-finished products are additives or fillers in various food products to improve their nutritional value
Andreev bound states at boundaries of polarized 2D Fermi superfluids with s-wave pairing and spin-orbit coupling
Authors: Thompson Kadin , Brand Joachim , Zuelicke Ulrich
Published: May 2023

A topological superfluid phase characterized by an emergent chiral-p-wave pair potential is expected to form in a two-dimensional Fermi superfluid subject to s-wave pairing, spin-orbit coupling and a large-enough Zeeman splitting. Andreev bound states appear at phase boundaries, including Majorana zero modes whose existence is assured by the bulk-boundary correspondence principle. Here we study the physical properties of these subgap-energy bound states at step-like interfaces using the spin-resolved Bogoliubov-de Gennes mean-field formalism and assuming small spin-orbit coupling. Extending a recently developed spin-projection technique based on Feshbach partitioning [SciPost Phys. 5, 016 (2018)] combined with the Andreev approximation allows us to obtain remarkably simple analytical expressions for the bound-state energies as well as the majority and minority spin components of their wave functions. Besides the vacuum boundary, where a majority-spin Majorana excitation is encountered, we also consider the boundary between the topological and a nontopological superfluid phase that can appear in a coexistence scenario due to the first-order topological phase transition predicted for this system. At this superfluid-superfluid interface, we find a localized chiral Majorana mode hosted by the minority-spin sector. Our theory further predicts majority-spin subgap-energy bound states similar to those found at a Josephson junction between same-chirality p-wave superfluids. Their presence affects the Majorana mode due to a coupling of minority and majority spin sectors only in the small energy range where their spectra overlap. Our results may inform experimental efforts aimed at realizing and characterizing unconventional Majorana quasiparticles.
Holographic thermal correlators from supersymmetric instantons
Authors: Dodelson Matthew , Grassi Alba , Iossa Cristoforo , Lichtig Daniel Panea , Zhiboedov Alexander
Published: May 2023

We present an exact formula for the thermal scalar two-point function in four-dimensional holographic conformal field theories. The problem of finding it reduces to the analysis of the wave equation on the AdS-Schwarzschild background. The two-point function is computed from the connection coefficients of the Heun equation, which can be expressed in terms of the Nekrasov-Shatashvili partition function of an SU(2)SU(2) supersymmetric gauge theory with four fundamental hypermultiplets. The result is amenable to numerical evaluation upon truncating the number of instantons in the convergent expansion of the partition function. We also examine it analytically in various limits. At large spin the instanton expansion of the thermal two-point function directly maps to the light-cone bootstrap analysis of the heavy-light four-point function. Using this connection, we compute the OPE data of heavy-light double-twist operators. We compare our prediction to the perturbative results available in the literature and find perfect agreement.
ACTIVITE DES URGENCES PSYCHIATRIQUES DURANT LA PANDEMIE (COVID-19): EXPERIENCE DE MARRAKECH
Authors:   Activity of Psychiatric Emergencies During the Pandemic (Covid-19): Marrakech Experience., AIT IDAR A. , Mouachi S. ,   Activity of Psychiatric Emergencies During the Pandemic (Covid-19): Marrakech Experience., EL FELLAH S. ,   Activity of Psychiatric Emergencies During the Pandemic (Covid-19): Marrakech Experience., ADALI I. ,   Activity of Psychiatric Emergencies During the Pandemic (Covid-19): Marrakech Experience., MANOUDI F. ,   Activity of Psychiatric Emergencies During the Pandemic (Covid-19): Marrakech Experience.
Published: May 2023

IbnNafiss Hospital is a psychiatric university center that covers a large region, with a population over three millions. During the period of the pandemic (covid-19), the activity of psychiatric emergencies experienced a marked change. At the start of the pandemic and during the confinement period, we noted a drop in the flow of patients associated with a drop in the number of hospitalizations. After the deconfinement, we noticed an increase in the numbers of consulting patients, however the numbers of hospitalizations did not increase despite the important demand for care. The most diagnoses commonly founded, were psychosis and depression, althought a higher percentage of anxiety disorders was expected. Several adjustments have been made to maintain the daily activity of the hospital.
Tipologías familiares, amor y crianza humanizada: el reto de la subjetividad familiar
Authors: Tirado Hincapie Daniel felipe , López Arboleda Gloria Maria
Published: May 2023

El presente artículo da cuenta de una reflexión que vincula tres categorías principales: tipologías familiares, amor y crianza humanizada, en el marco de la subjetividad familiar, entendida esta, como reto y tarea inacabada. La metodología para la construcción de este artículo de reflexión no derivado de investigación incluyó las reflexiones críticas, que, en triangulación con fuentes bibliográficas, ambos autores realizaron durante los encuentros académicos llevados a cabo en el marco del curso Trabajo de grado II de la Especialización en Terapia Familiar de la Universidad Católica Luis Amigó. Los hallazgos apuntan a repensar la crianza humanizada vinculada a cualquier tipología familiar, ya que se entiende el amor como posible sello universal para la misma. Se concluye, que el ejercicio de la crianza ha de ser impartido desde los mismos criterios de amor, escucha, comprensión, límites y seguridad, independiente de la tipología familiar de la que se trate, para ir mitigando, además, los imaginarios de una sociedad que, en términos generales e históricos, ha tenido como modelo a la familia nuclear.
Posgrados en psicología y ciencias sociales: una reflexión tras una década de formación
Authors: Rincón Dubis Marcela , Restrepo Segura Yusty Carolina , Osorio Tamayo Dora Liliana , Ruiz Zuluaga Elizabet , Bedoya Cardona Ledy Maryory , Correa Pérez Luisa Fernanda , Rodríguez Bustamante Alexander
Published: May 2023

El presente escrito evidencia una reflexión y diálogo académico entre los coordinadores de los posgrados de psicología frente al aporte e impacto social que han tenido los programas durante estos 10 años de la Escuela de Posgrados. Se reconocen algunos elementos que han sido recuperados de los testimonios de los estudiantes y graduados referente asu paso por la Universidad Católica Luis Amigó recogidos en dos apartados. El primero muestra el aporte del componente teleológico de la institución a la formación posgradual expresado en relatos de los graduados que se recogieron en los encuentros de autoevaluación desarrollados en el año 2019; y el segundo expone el papel de los profesionales en la transformación y generación de cambio social desde las diferentes áreas de formación.
La vida erótico sexual de jóvenes y adultos durante la pandemia del covid-19: Una reflexión documental
Authors: Jimenez Carvajal Daniela , Herrera Rúa Verónica , Vélez González Jhon Bayron , Yepes Correa Doris Adriana
Published: May 2023

El erotismo como proceso fundamental del amor y de la sexualidad humana ha existido desde tiempos antiguos y se relaciona, de manera transversal, con todas las dimensiones del ser humano. El presente artículo reflexiona sobre las transformaciones que se dieron en la vida erótico sexual de jóvenes y adultos durante la pandemia del covid-19; así las cosas, y a través de una exploración documental, se analizaron los cambios y las consecuencias en la dimensión sexual del ser humano durante dicho momento atípico, dadas sus características de aislamiento que conllevaron cambios psicosocioemocionales. Esta reflexión transita desde la aparición del coronavirus y las medidas restrictivas que previenen su propagación, hasta los procesos de adaptación al nuevo contexto que transforma las prácticas sexuales. El artículo concluye mencionando la virtualización del erotismo, como la principal consecuencia de este fenómeno.
Somos tres, cuatro o más (+): Hacia la construcción de vínculos sexuales libres
Authors: Gallo Botero Manuela , Fernández Arango Gloria Amparo , Correa Gallego Kelly Alejandra , Carmona Duque Paula Andrea , Montero Duque Yuri Vanessa , López Arboleda Gloria María
Published: May 2023

La relación de pareja está permeada por un sinnúmero de significados que atraviesan las diferentes dinámicas sexuales y la formación de vínculos, en búsqueda de un sentido, desde tiempos inmemorables. El presente artículo pretende ofrecer un acercamiento a la comprensión de las nuevas dinámicas de vinculación sexual, en parejas estables de Latinoamérica, en el último decenio del siglo XXI. A partir de una revisión documental, el artículo muestra las nuevas formas del amor que han estado presentes en el tiempo, evidenciando que, aunque están inmersas en creencias, culturas y la misma sociedad, continúan siendo un tema tabú, acompañadas, además, de un gran vacío de información al respecto. El artículo comienza mostrando los tránsitos históricos de la sexualidad en pareja, pasando por la reflexión del vínculo afectivo romántico y sexual afectivo, para culminar con una disertación en torno a las diversas prácticas sexuales no monógamas. En definitiva, el artículo concluye con una invitación a entender la resignificación de la vida sexual en pareja, orientada a nuevas transformaciones, sentidos y novedosas formas de ver y experimentar el amor y la sexualidad.
lado oculto de la maldad: La mujer psicópata y criminal
Authors: Pineda Sánchez Yesica Viviana , Mosquera Romero Sandra Patricia , Osorio Cardona Ana Maria , López Marín Magaly
Published: May 2023

El objetivo del presente artículo resultado de investigación fue comprender el lugar que ha ocupado históricamente la mujer en relación con el crimen y con la psicopatía, a partir de las investigaciones realizadas en los últimos diez años. La investigación se enmarca en el enfoque histórico hermenéutico, tiene un diseño cualitativo y utilizó la estrategia metodológica estado del arte. Se llega a la conclusión de que actualmente no hay consonancia en la comunidad científica respecto a la génesis y definición de la psicopatía, lo que impacta negativamente en el proceso clínico psicológico. Dentro de los grupos sociales existe una predisposición para asumir a la mujer el papel de víctima y es difícil que se le otorgue rótulo de infractora, pues los roles sociales han impactado en la formación de un estereotipo bajo el cual la mujer es inofensiva. Por otra parte, la investigación concluye que se hace pertinente realizar investigaciones que permitan profundizar la concepción de psicopatía, extendiendo este conocimiento al impacto jurídico de la mujer psicópata y criminal; específicamente en Colombia, en donde no hay una clara perspectiva panorámica respecto a este fenómeno.
Sobre la humillación y el desprecio como formas del mal moral
Authors: Viveros Chavarría Edison Francisco
Published: May 2023

El problema que quiere plantearse en este escrito es que, si existe una respuesta afectiva y a la vez racional que le dé un lugar a la indignación por la vida precaria de los demás, negándose a cualquier práctica de humillación y desprecio, entonces podrá hacerse más extensiva una vida buena y moralmente plausible. En este sentido, la tesis de este texto es: la actitud moral de la indignación implica la facultad de vivenciar y aceptar que la humillación y el desprecio son formas del mal moral que se puede instaurar en la propia vida y en la relación entre seres humanos. Se concluye que una vida es dignificada si y sólo sí es tratada desde el valor que tiene en sí misma y en consecuencia una sociedad muestra su estatus moral si crea mecanismos para respetar a las personas en su dignidad
Las TIC en la pandemia como fenómeno social complejo para el psicólogo educativo
Authors: Chica Ríos Rubiel Alberto
Published: May 2023

El presente texto busca resaltar la relevancia que tiene para el psicólogo educativo los problemas y trastornos sociales, psicopedagógicos y de salud ocasionados por el uso de las TIC, y la manera cómo pueden ser detectados e intervenidos para evitar el desarrollo de adicciones y demás trastornos físicos, psicológicos y emocionales que pueden derivarse de los mismos. Al tener mayor claridad sobre los trastornos sociales generados por las TIC, entenderemos mejor todos los fenómenos sociales y psicólogos educativos, comprendiendo que el concepto de trastorno se refiere a una entidad clínica, médica o psicosocial establecida por las ciencias de la salud y psicopatología. Nuestro papel es encontrar un punto medio entre la necesidad de mantenernos conectados e informados en estos tiempos de aislamiento social y el abuso desmedido que genera una adicción con todas sus consecuencias para la salud física, mental y emocional.
Relaciones sociales y protección social de personas migrantes en Euskadi desde un enfoque narrativo
Authors: Gatica Lucas
Published: May 2023

El bienestar social se ha considerado durante mucho tiempo algo que los Estados y sus instituciones brindan a sus ciudadanos. Por otro lado, los últimos datos señalan que el 3,5% de la población mundial vive en un país en el que no ha nacido. En ese contexto, ¿qué lugar ocupan las relaciones sociales de las personas migrantes en su bienestar y qué relación tienen esas interacciones con el acceso a distintos recursos? Este artículo analiza narrativas en torno al bienestar social de las personas migrantes latinoamericanas que residen en Euskadi y su relación con las relaciones sociales que utilizan. Se señala que amistades duraderas, contactos trascendentales y la existencia de una red de apoyo previa a la llegada a la nueva sociedad son fundamentales en el proceso de integración y podrían jugar un papel en el bienestar socioemocional de los/as migrantes. Se discuten las narrativas y se analiza la importancia de estos elementos en la esfera “social”. De este modo, pretendemos acercarnos al proceso de integración de los/as migrantes cuestionando el argumento que exclusivamente las relaciones con personas de la sociedad mayoritaria promueven la integración y la protección.
On solution of two-sided vector equation in tropical algebra
Authors:   St. Petersburg State University, Krivulin Nikolai K.
Published: May 2023

The problem of solving, in the context of tropical mathematics, a vector equation with two given matrices and unknown vectors, each part of which has the form of a product of one of the matrices and an unknown vector, is considered. Such an equation, which has unknown vectors on either side of the equal sign, is often called a two-sided equation. A new procedure for solving the two-sided equation is proposed based on minimizing a certain distance function between vectors of tropical vector spaces that are generated by the columns of each of the matrices. As a result of the procedure, a pair of vectors is obtained, which provides a minimum distance between spaces and the value of the distance itself. If the equation has solutions, then the resulting vectors are the solution to the equation. Otherwise, these vectors define a pseudo-solution that minimizes the deviation of one side of the equation from the other. The execution of the procedure consists in constructing a sequence of vectors that are pseudosolutions of the two-sided equation in which the left and right sides are alternately replaced by constant vectors. Unlike the well known alternation algorithm, in which the corresponding inequalities are solved one by one instead of equations, the proposed procedure uses a different argument, looks simpler, and allows one to establish natural criteria for completing calculations. If the equation has no solutions, the procedure also finds a pseudo-solution and determines the value of the error associated with it, which can be useful in solving approximation problems.
Composite wing vibration coupling control
Authors:   St. Petersburg State University, Ryabov Victor M. , Yartsev Boris A. ,   St. Petersburg State University,   Krylov State Research Center
Published: May 2023

The paper discusses the possibility to control coupled bending-twisting vibrations of composite wing by means of the monoclinic structures in the reinforcement of the plating. Decomposing the potential straining energy and kinetic energy of natural vibration modes into interacting and non-interacting parts, it became possible to introduce the two coefficients that integrally consider the effect of geometry and reinforcement structure upon the dynamic response parameters of the wing. The first of these coefficients describes the elastic coupling of the natural vibration modes, the second coefficient describes the inertial one. The paper describes the numerical studies showing how the orientation of considerably anisotropic CRP layers in the plating affects natural frequencies, loss factors, coefficients of elastic and inertial coupling for several lower tones of natural bending-twisting vibrations of the wing. Besides, for each vibration mode, partial values of the above mentioned dynamic response parameters were determined by means of the relationships for orthotropic structures where instead of “free” shearing modulus in the reinforcement plant, “pure” shearing modulus is used. Joint analysis of the obtained results has shown that each pair of bendingtwisting vibration modes has its orientation angle ranges of the reinforcing layers where the inertial coupling caused by asymmetry of the cross-section profile with respect to the main axes of inertia decreases, down to the complete extinction, due to the generation of the elastic coupling in the plating material. These ranges are characterized by the two main features: 1) the difference in the natural frequencies of the investigated pair of bendingtwisting vibration modes is the minimum and 2) natural frequencies of bending-twisting vibrations belong to a stretch restricted by corresponding partial natural frequencies of the investigated pair of vibration modes. This result is of practical importance because it enables approximate analysis of real composite wings with complex geometry in the existing commercial software packages.
Influence of land use changes on groundwater quality – Bafoussam, West Cameroon
Authors: Nguedia Kevin Djatsa , Ndongo Barthelémy , Ntankouo Njila Roger , Kagou Dongmo Armand
Published: May 2023

The purpose of this work was to show that the change in land use impacts the quality of free groundwater and therefore the health of the population in the city of Bafoussam. Land use was dominated by housing (about 42%) followed by agricultural areas (33%) and green space. The socio-economic diagnosis by the guided survey showed that 62.5% of the population consumes CAMWATER water with malaria as the dominant water-related disease. The collection of water samples analysed by the colorimetric and photometric assay has allowed us to obtain a dominant water facies of the chloride and sulphate–calcium–magnesium type. The mapping of areas potentially vulnerable to pollution by ArcGIS 10.8 software presents the low-lying areas, downstream of agricultural sites, close to industries and neighbourhoods with strong urban disorder as the most vulnerable to pollution and therefore retained as actors of diffuse groundwater pollution in the city of Bafoussam. Thus, the change in land use and the increase in agglomeration degrade the quality of groundwater in this city.
Impact of water–tourism–ecosystem nexus on the sustainable development of eco-city
Authors: Zhu Kun
Published: May 2023

Tourism places substantial stress on regional land use that can lead to ecological deterioration, greater pollution, destruction of natural habitats, and increasing threats to species already in danger of extermination. Improved quality of life is made possible through the Fuzzy Hamacher Correlated Geometric (FHCG) method to observe the growth of multiple attributes in a water-based leisure tourism eco-city. Geographic Information System (GIS) technology, land use maps, and an executive segment satellite image are the main areas of attention for eco-cities as the main focus, which are supported by ecology and environmental space. Hence, FHCG-GIS has designed an environmental carrying capacity in eco-cities that can be increased through tourists who can be accepted in a specific location to fulfill the needs of water tourism, help the destination sector, protect the environment, and reduce the effect. A sensible outcome for evaluating the planning conditions in an eco-city can be found in the estimated indicators of water leisure tourism environmental carrying capacity, predicated on an analysis of scenic geographical resources and tourism economic conditions, and the results of the scenic area's integrated limits using barrel extrapolation.
Collagenous Colitis associated with Celiac Disease
Authors: Malaeb Maher , Mahboub Sameera , Howeedy Aly
Published: May 2023

Introduction:

Microscopic colitis is an inflammatory GI condition whereby patients present predominantly with chronic watery diarrhea associated with other non-specific symptoms such as abdominal pain, urgency, fecal incontinence, weight loss, arthralgia, myalgia, anxiety, depression, and fatigue, which negatively impact their quality of life.

Case Presentation:

We present a case of a 44 -year old female with a history of hypothyroidism and celiac disease who presented to the GI clinic with a history of more than ten diarrhea episodes per day along with mild abdominal pain and bloating.

Conclusion:

A colonoscopy was performed, and a random colon biopsy revealed collagenous/microscopic colitis.
Evaluating Gut Microbiota Modification as a Next-Generation Therapy
for Obesity and Diabetes
Authors: Hossain Md. Imran , Akash Sajidur Rahman , Faruk Md. Omor , Mimi Sanjida Islam , Chowdhury Imtiaj Hossain , Islam Md Shariful , Alam Md. Mahbubol , Ali Md. Sarafat
Published: May 2023

The human body is a complex ecosystem that thrives on symbiosis. It is estimated that
around 10^14 commensal microorganisms inhabit the human body, with the gut microbiota being
one of the most diverse and complex populations of bacteria. This community is thought to comprise
over a thousand different species that play a crucial role in the development of critical human
diseases such as cancer, obesity, diabetes, mental depression, hypertension, and others. The gut
microbiota has been identified as one of the most recent contributors to these metabolic disorders.
With the emergence of inexpensive and high-performance sequence technology, our understanding
of the function of the intestinal microbiome in host metabolism regulation and the development of
(cardio) metabolic diseases has increased significantly. The symbiotic relationship between the gut
microbiota and the host is essential for properly developing the human metabolic system. However,
if this balance is disrupted by various factors such as infection, diet, exercise, sleep patterns, or
exposure to antibiotics, it can lead to the development of various diseases in the body, including
obesity and diabetes type 1 and 2. While many approaches and medications have been developed
globally to treat these diseases, none have proven to be entirely effective, and many show side effects.
Therefore, scientists believe that treating the gut microbiota using tried-and-true methods is
the best option for combating obesity and diabetes. In this study, we aim to identify several feasible
ways and prospects for gut microbiota therapy that can shape a new format for the treatment of
obesity and diabetes.
A Comprehensive Review of the Docking Studies of Chalcone for the
Development of Selective MAO-B Inhibitors
Authors: Krishna Athulya , Kumar Sunil , Sudevan Sachithra Thazhathuveedu , Singh Ashutosh Kumar , Pappachen Leena K. , Rangarajan T.M. , Abdelgawad Mohamed A. , Mathew Bijo
Published: May 2023

Monoamine oxidase B is a crucial therapeutic target for neurodegenerative disorders like
Alzheimer's and Parkinson's since they assist in disintegrating neurotransmitters such as dopamine in
the brain. Pursuing efficacious monoamine oxidase B inhibitors is a hot topic, as contemporary
therapeutic interventions have many shortcomings. Currently available FDA-approved monoamine
oxidase inhibitors like safinamide, selegiline and rasagiline also have a variety of side effects like
depression and insomnia. In the quest for a potent monoamine oxidase B inhibitor, sizeable, diverse
chemical entities have been uncovered, including chalcones. Chalcone is a renowned structural
framework that has been intensively explored for its monoamine oxidase B inhibitory activity.The
structural resemblance of chalcone (1,3-diphenyl-2-propen-1-one) based compounds and 1,4-diphenyl-
2-butene, a recognized MAO-B inhibitor, accounts for their MAO-B inhibitory activity. Therefore,
multiple revisions to the chalcone scaffold have been attempted by the researchers to scrutinize the
implications of substitutions onthe molecule's potency. In this work, we outline the docking
investigation results of various chalcone analogues with monoamine oxidase B available in the
literature until now to understand the interaction modes and influence of substituents. Here we focused
on the interactions between reported chalcone derivatives and the active site of monoamine oxidase B
and the influence of substitutions on those interactions. Detailed images illustrating the interactions
and impact of the substituents or structural modifications on these interactions were used to support
the docking results.
Effects of COVID-19 Pandemic on the Mental Health of Women and
Treatment of Mental Disorders in the Unani System of Medicine: An
Overview
Authors: Ateeque Ahmed Sana Kauser , Sidra  , Sheema  , Jahan Nasreen , Ansari Abid Ali
Published: May 2023

Background:

The world miserably collapsed when the COVID-19 (Coronavirus disease)
pandemic was going out of control. The ongoing crisis has damaging effects on the mental
health of individuals, predominantly women, in both developed and developing countries. Women
in developing countries, both as frontline workers and at home, are at increased risk of mental
health problems (specifically mental disorders). A few observational studies related to the COVID-
19 pandemic have reported a higher prevalence of mental health problems like stress, anxiety, depression,
insomnia, fear, delirium, hysteria etc. among women compared to men. Thus, understanding
the effects of the COVID-19 pandemic on women's mental health are as important to discuss
as their physical health effects.

Objective:

The Unani System of Medicine (USM) has a holistic approach to preventing, treating,
and curing mental disorders. The present article aimed to provide an overview of the effects of the
COVID-19 pandemic on women's mental health and its containment measures described in classical
Unani texts besides their relevance in the current outbreak.

Materials and Methods:

A manual literature survey of classical Unani literature such as Firdaus-
al-hikmat, Al Qanoon-fit-tib, Zakheera Khwarzam Shahi, and Kamilus Sana was conducted to
collect the information available on the strategic approaches of health promotion and disease prevention
in Unani Medicine. To obtain the appropriate English equivalent words for Unani terms
and the scientific name of the drugs, “Standard Unani Medical Terminology” and “Classification
of Unani Drugs” were consulted, respectively. Many pharmacological books and papers were considered
from PubMed, Google Scholar etc.

Results:

According to the literature review results, Unani doctors have pushed the adoption of personalised
and predictive methods for preserving health and preventing diseases. The main focus is
to treat the fragile population, i.e., women affected by mental illnesses.

Conclusion:

The present article emphasizes the mental health problems among women provoked
by the COVID-19 pandemic, their possible etiopathogenesis, prevention, and psychological, regimental
and pharmacological management of the USM.
Evaluation of the Toxicological Effects from Bothrops Jararacussu Snake
Venom on Zebrafish (Danio Rerio) Embryos and Larvae
Authors: da Silva Layssa Gualberto , De Abreu Oliveira Pierri Emanoel , dos Santos Pedro Gabriel Nascimento , Costa Ribeiro  Souza Juliana Alves , Martins Rafael Xavier , de Lima Maria Caroline Lourenço , de Souza Falcão Erica , Farias Davi Felipe , Marchi-Salvador Daniela Priscila
Published: May 2023

Introduction:

Approximately 90% of reported and identified cases of snakebites in Brazil are caused by species belonging to the Bothrops genus. These snakes have clinical rele-vance due to their venom composition, which contains substances capable of triggering local and systemic effects, leading to morbidities and/or mortality.

Objective:

The objective of this study was to evaluate the toxic and toxinological effects of Both-rops Jararacussu snake venom on zebrafish embryos and larvae.

Methods:

The stability of B. Jararacussu snake venom under the conditions used in the toxicity experiments in zebrafish embryos and larvae was evaluated on citrated human plasma. Zebrafish embryos and/or larvae mortality, morphological alterations, spontaneous tail movements and heartbeat caused by the venom were quantified within 96 hours. Toxicity parameters and activity of enzyme-related toxicity biomarkers were evaluated in zebrafish after 96 hours of semi-static exposure to the venom.

Results:

The results indicated that the venom causes toxicity in zebrafish embryos and larvae, in-ducing embryonic mortality, alteration in the number of spontaneous tail movements and activity of biomarker enzymes. The results suggested that the toxic effects caused by the venom in the ear-ly stages of zebrafish development are mediated, in part, by neurotoxic action, induction of oxida-tive and metabolic stress caused by low molecular weight components, and proteins present in this venom.

Conclusion:

Toxinological evaluations using the zebrafish as a model are scarce; however, this study presented promising results that encourage the development of future research in toxinology using this animal as a model organism.
Mechanical Characterization of Curaua Fiber/Babool Wood Particle
Reinforced Polyester Hybrid Composite
Authors: Suthan R. , Rao A. Padma , Aurtherson P.Babu , Arul Sujin Jose , Ajan K. , Jenaris D.S.
Published: May 2023

Background:

The researchers are in the situation to satisfy the demand for engineering
materials by developing novel eco-friendly materials. The natural fiber composites are the
substitutes for the synthetic material.

Introduction:

The mechanical properties of curaua fiber-reinforced polyester (CFRP) composites
were investigated, as well as the effects of curaua fibre infusion with Babool Wood particles
(BWP).

Methods:

The composite specimens were fabricated using a hand lay-up approach using varying
amounts of curaua fibres (CF) and babool wood particles in a 1:1 ratio in order to test the tensile
strength and flexural strength.

Results:

The results demonstrated that before weakening, the tensile strength and flexural
strength of the composite samples rose by up to 40% for hybrid reinforcements. Comparing samples
made of pure resin to those made of the composite at 40 weight percent (CF20/BWP20), the
tensile and bending strengths of the composite are improved by 93.42% and 86.4%, respectively.

Conclusion:

The tensile and flexural modulus values of the hybrid composites increased by up to
50% fiber, but less successfully (CF25 and BWP25). The fracture mechanism of the shattered
composite samples was examined using scanning electron microscopy.
Introduction: Immune System & Modulation of Immune System
Authors: Dalvi Manali S. , Sawant Sanjay D. , Nikam Vandana S.
Published: May 2023

The immune system is a complex, intricate organ system with features like
flexibility, recognition, discriminating potential between self from non-self, and
memory to defeat notorious external and internal threats to human health functioning.
Innate immunity is inborn, and acquired immunity develops through secondary
education; they are interconnected, interdependent, and execute tasks with bi directional communications. A deeper understanding of immune biology revealed a
remarkable contribution of the immune system in several chronic illnesses, and has
taken a central stage in pathophysiology. In essence, the weakened or overactivated
immune system leads to these chronic illnesses. Modulation of the immune system is
an efficient and valid approach to prevent the underlying pathophysiology of such
diseases. A gamut of natural immunomodulators targeted at specific or non-specif
immune cells has delineated their potential to achieve the equilibrated and balanced
immune system. Preclinical and clinical studies demonstrated the implication of
microbiota, nutrients, natural herbs, and micronutrients for immunostasis. The immune
system's complexity, its close association with the endocrine and nervous system, target
identification, and convenient, reliable tools to assess immune function and modulation
are a few limitations that hampered the attainment of immunostasis. Despite these
limitations, novel therapies targeted at immunomodulation in chronic diseases are
promising and paving the future path to novel therapeutics
Natural Sources of Immunomodulators
Authors: Bhange Vishal , Kale Monika , Dudhal Ankita , Putta Nikhil , Abhyankar Mukta , Jagtap Supriya , Nikam Vandana S.
Published: May 2023

Nature is replete with an arsenal of compounds that can be investigated for
their therapeutic potential. The immune system involvement in severe chronic illnesses
or emerging infectious diseases has provided clinical evidence. The prevention and
treatment of these diseases targeted at the immune system with natural
immunomodulators are gaining momentum, owing to their diverse array of activities.
Treating acute illnesses with modern medicines has been successful; however, treating
chronic illness treatment remains elusive and disappointing. Notably, this chapter
reviews the natural resources of immunomodulators. Natural immunomodulators from
plants, marine, and animals are of prime importance, and they possess many
pharmacological activities. Similarly, microbiota modifiers - prebiotics, probiotics, and
micronutrients- are imperative in restoring immune homeostasis. This chapter
summarizes these natural immunomodulators and their power to boost immunity and
human well-being. 
Future Path and Perspectives of Immunomodulators
Authors: Karne Megha , G. Jagtap Supriya , Sawarkar Sujata , S. Nikam Vandana
Published: May 2023

Immunity is the inherent ability of the body to fight against various infections, and foreign invaders. When the host body comes in contact with a foreign body, a series of chemical mediators are released, which collectively elicit an immune response. The biomolecules capable of stimulating, suppressing and modulating innate or acquired immunity, biological or synthetic in origin, are termed as immunomodulators or immunoaugmentors. Limited clinical use of synthetic immunomodulators has attracted the attention of researchers toward immunomodulatory characteristics of natural therapeutics. Though natural immunomodulators render their efficacy in several chronic illnesses, there are challenges that need to be addressed and resolved to make them viable alternate therapeutics. This chapter highlights the challenges and future perspectives of natural immunomodulators.
De beelden die ons bewegen, de voorspelbaarheid van de rampen die we samen creëren
Authors: Dückers Michel L.A.
Published: May 2023

Dat rampen en crises een enorme weerslag hebben op de levens van gedupeerden mag voor zich spreken. Dat dit het collectieve organisatievermogen van een samenleving op de proef stelt ligt eveneens voor de hand. Dat de huidige tijd onder spanning staat en dat een diversiteit aan crises en complexe problemen op elkaar inwerkt, is dagelijks onderwerp van gesprek. Het is onvermijdelijk dat dingen mis gaan, maar er lijken hardnekkige patronen in te zitten. Die patronen zijn alleen te doorbreken als we ze beter begrijpen. De beelden die ons bewegen, de voorspelbaarheid van de rampen die we samen creëren gaat hier dieper op in en reduceert de crisisopgave op het snijvlak van veiligheid en gezondheid tot zes elementen die in samenhang bepalen of crisisbeheersing voor gedupeerden goed uitpakt. Deze versimpeling verscherpt de opgave voor overheden en instanties – en onderstreept de noodzaak van integraliteit en ontschotting. Het illustreert bovendien waarom de klassieke crisisbeheersingsaanpak, met een focus op acute dreiging, ontoereikend is in een landschap van langdurig sluimerende crises. Waar in de risicosamenleving sterk naar de overheid werd gekeken om problemen aan te pakken, kunnen we er in de huidige crisissamenleving niet op vertrouwen dat de overheid dit alleen kan. Dit is een van de voorspelbare pijnpunten in de tijdslijn van zich ontvouwende rampen waarin we allemaal een aandeel (kunnen) hebben – deels in de problemen, maar hopelijk ook in de oplossing.
Refleksi guru pendidikan jasmani: Pedagogi efektif dalam persimpangan kritik
Authors: Setiawan Caly
Published: May 2023

Penelitan tentang refleksi guru tidak hanya jamak dilakukan dalam literatur pendidikan, tapi juga mendapatkan kritik dari berbagai perspektif. Meskipun diyakini manfaat refleksi dalam membantu meningkatkan kapasitas dan kompetensi mengajar guru, penelitian refleksi guru pendidikan jasmani masih jarang menjadi perhatian para peneliti sekalipun dalam ranah efektif. Tujuan penelitian ini adalah untuk mengeksplorasi refleksi guru pendidikan jasmani setelah sesi pengembangan profesi untuk meningkatkan kapasitas pedagogi efektif. Metode penelitian kualitatif menjadi acuan dalam mendesain penelitian ini. Sejumlah 13 guru menyetujui untuk berpartisipasi. Data dikumpulkan melalui focus group discussion (FGD) dan studi dokumen. Analisis data menggunakan analisis tematik dari Braun dan Clarke (2006) dengan dibantu perangkat lunak ATLAS.ti 22. Hasil analisis menunjukkan tiga tema yang meliputi (1) konseptualisasi pendidikan jasmani, (2) analisis pedagogi efektif, dan (3) kesadaran baru dan proyeksi pedagogi. Peneliti menyimpulkan bahwa pedagogi efektif memiliki makna dalam pengembangan kapasitas guru. Meskipun di dunia Barat menjadi sasaran kritik, dalam konteks geo-lokasi dan geo-politik yang berbeda, pedagogi efektif dibutuhkan sebelum peningkatan kualitas pendidikan jasmani dapat dilakukan.Abstract: Research on teachers’ reflection has not only been apparent in educational literature, but it has also attacked by critiques from different perspectives. Despite the benefits of reflection in helping teachers improve their capacity and competency, little attention has been pain to reflection among physical education teachers, even in the area of effective teaching. The purpose of the current study was to explore physical education teahers’ reflection after sessions of their professional development regarding effective pedagogy. Qualitative research method has been referred in designing the study. A number of 13 physical education teachers agreed to participate in the study. Data were collected through focus group discussion and document study. Thematic analysis from Braun dan Clarke (2006) was used to analysis the data with the help of qualitative data analysis computer program, called ATLAS.ti 22. Results showed three themes being constructed, (1) the conceptualization of physical education, (2) analysis of physical education pedagogy, and (3) new understanding and pedagogical projection in the future. I concluded that effective pedagogy has placed its central meanings to the teachers in this study. Despite in Western societies has been criticized, effective pedagogy was needed before other aspects of quality physical education has been addressed.
Signifikansi Kebugaran Jasmani Terhadap Prestasi Belajar Siswa Sekolah Dasar
Authors: Prastyawan Rifky Riyandi , Pulungan Khoirul Anwar
Published: May 2023

Kebutuhan kebugaran jasmani sangatlah penting terhadap pencapaian hasil belajar, karena kebugaran jasmani kemampuan tubuh untuk menyesuaikan tugas sehari-hari dengan tanpa kelelahan, mempunyai energi yang cukup untuk menikmati waktu luang maupun menghadapi waktu darurat setiap saat. Penelitian ini bertujuan untuk mengetahui pengaruh kebugaran jasmani terhadap prestasi belajar siswa Sekolah Dasar. Metode yang digunakan dalam penelitian kuantitatif dengan pendekatan ex post facto. Penelitian dilakukan pada bulan 2022. Sampel data adalah seluruh siswa kelas VI SDN Somoketro yang berjumlah 29 siswa. Instrumen penelitian yang digunakan ialah instrument Tes Kebugaran Jasmani Indonesia tahun 2010 yang terdiri dari lari 40 meter, gantung tekuk siku 30 detik, baring duduk 30 detik, loncat tegak 30 detik dan lari 600 meter. Untuk mengetahui prestasi belajar menggunakan nilai raport semester tahun 2020/2021. Teknik pengumpulan data dilakukan dengan tes dan dokumentasi. Hasil dari penelitian ini menunjukan bahwa bahwa kebugaran jasmani bukan salah satu faktor yang menentukan kenaikan maupun penurunan hasil belajar siswa. The need for physical fitness is very important for achieving learning outcomes, because physical fitness is the body's ability to adapt daily tasks without fatigue, has enough energy to enjoy free time and face emergencies at any time. This study aims to determine the effect of physical fitness on learning achievement of elementary school students. The method used in quantitative research is an ex post facto approach. The research was conducted in 2022. The data samples were all 29 students in class VI at Somoketro Elementary School. The research instrument used was the 2010 Indonesian Physical Fitness Test instrument which consisted of 40 meters running, 30 seconds of hanging elbows, 30 seconds of lying down, 30 seconds of upright jumping and 600 meters of running. To determine learning achievement, use the 2020/2021 semester report card scores. Data collection techniques are carried out by testing and documentation. The results of this study indicate that physical fitness is not a factor that determines the increase or decrease in student learning outcomes.