bluuebunny/crossref_metadata_2025 huggingface dataset:
Overexpression of TwSQS, TwSE and TwOSC Regulates Celastrol Accumulation in Cambial Meristematic Cells and Dedifferentiated Cells
Authors: Song Yadi , Zhou Jiawei , Zhang Yifeng , Zhao Yujun , Wang Xiujuan , Hu Tianyuan , Tong Yuru , Huang Luqi , Gao Wei
Published: October 2021

Squalene synthase (SQS), squalene epoxidase (SE) and oxidosqualene cyclase (OSC) are encoding enzymes in downstream biosynthetic pathway of triterpenoid in plants, but the relationship between the three genes and celastrol accumulation in Tripterygium wilfordii (T. wilfordii) still remains unknown. Gene transformation platform in plant can be used for fast studying gene function. However, there is no report on the application of cambial meristematic cells (CMCs) and dedifferentiated cells (DDCs) in genetic transformation platforms. Our aim was to study the effects of overexpression of TwSQS, TwSE and TwOSC on celastrol accumulation and terpenoid biosynthetic pathway-related gene expression through CMCs and DDCs platforms. Overexpression vectors of TwSQS, TwSE and TwOSC were constructed by Gateway technology and transferred into T. wilfordii CMCs and DDCs by gene gun. The content of celastrol was assayed and it significantly increased in CMCs compared with the control group after overexpression. However, there was no significant increment in celastrol was detected in DDCs. Meanwhile, the relative expression levels of TwSQS, TwSE, TwOSC and terpenoid biosynthetic pathway-related genes were detected. The relative expression levels of TwSQS, TwSE and TwOSC were all increased compared with the control group in both CMCs and DDCs. While the pathway-related genes displayed different expression trends. Therefore, it was verified in T. wilfordii CMCs that overexpression of TwSQS, TwSE and TwOSC increased celastrol accumulation and had different effects on the expression of related genes in terpenoid biosynthetic pathway, laying a foundation for further elucidating the downstream biosynthetic pathway of celastrol through T. wilfordii CMCs platform.
Pharmacologic compound to mitigate presbyopia symptoms
Authors: Galeana Cesar A Sanchez
Published: October 2021

Purpose
To assess the effect of a compound of low dose Pilocarpine, Brimonidine and Oxymetazoline (PBO) in a group of presbyopic individuals.
Materials and Methods
We recruited a group of 11 presbyopic individuals from June to July 2020. The PBO compound was instilled in the non-dominant eye and low Pilocarpine or Brimonidine alone were instilled in the other eye. Under corrected near visual acuity using the Jaeger notation, under corrected and corrected distance visual acuity, intraocular pressure, pupil diameter, and lines gained were recorded before and one hour after instillation of the drops.
Results
One hour after drops binocular Jaeger was 2.45 +/ 1.36 SD range (1 – 4) (p ≤ 0.003) PBO in the non-dominant eye Jaeger was 2.09 +/- 1.446 SD range (1 – 5) (p ≤ 0.0001) Jaeger in the dominant eye with Pilocarpine or Brimonidine 3.82 +/-1.601 SD range (1 – 6) (p ≤ 0.032). Jaeger in eyes instilled with Pilocarpine 4.20 +/-1.483 SD range (2 – 6) (p ≤ 0.102). Jaeger in eyes instilled with Brimonidine 3.50 +/-1.761 range (1 – 5) (p ≤ 0.250). Lines gained PBO non dominant eye 3.73 +/-1.42 SD range (2 – 6) Lines gained in the dominant eye with Pilocarpine or Brimonidine 2 +/-1.89 SD range (0 – 6). Lines gained in eyes with Pilocarpine 1.60 +/-0.89 SD range (1 – 3). Lines gained in eyes with Brimonidine 2.33 +/- 2.50 SD range (0 – 6).
Discussion
Low dose Pilocarpine, Brimonidine, Oxymetazoline compound showed effectiveness improving near distance vision one hour after instillation compared to low dose Pilocarpine and Brimonidine alone in a group of 11 presbyopic individuals.
Synchronization of Ewe Lambs During Non-Breeding Season: Comparing Clomiphene Citrate-Based Protocols With Progesterone+eCG Protocol
Authors: Ebrahimi Marziyeh , Aghamohammadzadeh Roghayeh , Moghaddam Gholamali , Kia Hossein Daghigh , Ghasemi-Panahi Babak , Kianifard Davoud
Published: October 2021

Synchronization can improve reproductive performance of ewe lambs during non-breeding season. Accordingly, the aim of this study was to evaluate reproductive performance of ewe lambs during non-breeding season using different clomiphene citrate (CC) protocols compared with progesterone sponge (PS)+equine chorionic gonadotropin (eCG) protocol. In this study, 40 Ghezel ewe lambs were divided into four experimental groups based on the completely randomized design. Experimental groups were as follows: 1- PS (12 days)+eCG (500 I.U. eCG); 2- PS (12 days)+CC (100 mg CC, 5 days); 3- CC (100 mg CC, 5 days)+eCG group (500 I.U. eCG); 4- CC (100 mg CC, 5 days). Ram introduction was done between 13 and 18 days. Blood samples were taken on 1, 11, 14, and 40 days, and serum levels of estrogen and progesterone were measured. Pregnancy was evaluated at the last trimester of expected pregnancy (by sonography). Based on the results, the effects of treatments and the interaction of treatments × time on estrogen and progesterone concentrations were significant (P<0.05). Pregnancy and lambing rates were significantly affected by estrus synchronization treatments and the highest pregnancy was observed in PS+eCG group (P<0.05). Based on the overall results of the present study, the best synchronization method during non-breeding season for ewe lambs was PS+eCG.
Sintilimab With Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Squamous Non-small-cell Lung Cancer: Real-world Data Study
Authors: Lin Xinqing , Deng Haiyi , Li Suyang , Xie Xiaohong , Chen Chao , Cai Longqiu , Yang Yilin , Qiu Guihuan , Xie Zhanhong , Qin Yinyin , Liu Ming , Zhou Chengzhi
Published: October 2021

Purpose:The ORIENT-12 study demonstrated the promising results of sintilimab combined with gemcitabine and platinum (GP) therapy in squamous non-small-cell lung cancer (sqNSCLC) patients. However, the efficacy of sintilimab plus paclitaxel/nab-paclitaxel and platinum (TP) in sqNSCLC is not yet known. Methods: Real-life data were collected from patients with untreated locally advanced or metastatic sqNSCLC who were treated with sintilimab plus TP (arm A) or sintilimab plus GP (arm B) between January 2019 and January 2021. Results:A total of 52 patients were included (arm A, n=32 and arm B, n=20). After a median follow-up of 12.1 months, the median PFS was 10.9 months (95% confidence interval [CI], 5.0 to 16.7) in arm A and 7.5 months (95% CI, 4.0–10.9) in arm B (hazard ratio [HR], 0.64; 95% CI, 0.30 to 1.4; P = 0.24). The median overall survival was 20.1 months (95% CI, 13.6 to 26.6) in arm A and 16.3 months (95% CI, 2.9 to 29.6) in arm B (HR, 0.69; 95% CI, 0.26–1.84; P = 0.46). The overall response rate was 59.4% in arm A and 40.0% in arm B. Adverse events of grade 3 or higher occurred in 37.5% of the patients in arm A and 55.0% of the patients in arm B. Conclusions: Sintilimab-TP exhibits similar clinical benefits compared with sintilimab-GP in patients with untreated advanced or metastatic sqNSCLC.
Elderly And Burn Injuries: A Ten-Year Analysis of 612 Patients
Authors: Dogahe Zahra Haghani , Zarei Reza , Hallaj Shahin , Mobayen Mohammadreza
Published: October 2021

Background: With all the progress made in geriatric medicine, we expect to have a growing population of elderly soon. With burn injuries, as one of the most common unpredictable injuries to the elderly, it is essential to clarify the epidemiological pattern and factors related to worse outcomes in geriatric burn patients. We aimed to investigate burn characteristics in the elderly in Guilan province, IRAN, in ten years.Methods: This study conducted a retrospective analysis of burn patients aging 60yrs and over in Velayat Burn Center between 2010 and 2020. The data collected from the hospital information system included age, sex, marital state, occupation, residency, season and month of the incident, place of incident, total body surface area (TBSA), burn degree, cause of the burn, anatomical site of the injury, pre-injury morbidities, surgical managements, length of hospital stay and mortality.Results: Among 612 patients, the mean age was 72.20±8.94 years. The female to male ratio was 1.14:1 with a total of 53.3% female burn patients. 94.90% of patients lived with family members. 59.3% lived in urban areas. Most of the burn injuries happened during winter and summer. 82.5% happened indoors. The mean was 19.70±22.13%. The most common causes were flames (50.0%) and scalds (44.3%). The mean length of hospital stay (LOS) was 6.14±6.27 days. The overall mortality rate was 15%.Conclusion: We concluded that most burn injuries among the geriatric population happen indoors, during the first hours of the day, and on the first day of the week, making it essential to establish special prevention programs suiting these situations. On the other hand, with the increased life expectancy and the unpredictable nature of burn injuries, it is essential to identify risk factors and establish prevention programs for the elderly.
Attentional Influences on Neural Processing of Biological Motion in Typically Developing Children and Those on the Autism Spectrum
Authors: Knight Emily J. , Krakowski Aaron I. , Freedman Edward G. , Butler John S. , Molholm Sophie , Foxe John J.
Published: October 2021

Background

Biological motion imparts rich information related to the movement, actions, intentions and affective state of others, which can provide foundational support for various aspects of social cognition and behavior. Given that atypical social communication and cognition are hallmark symptoms of autism spectrum disorder (ASD), many have theorized that a potential source of this deficit may lie in dysfunctional neural mechanisms of biological motion processing. Synthesis of existing literature provides some support for biological motion processing deficits in autism spectrum disorder, although high study heterogeneity and inconsistent findings complicate interpretation. Here, we attempted to reconcile some of this residual controversy by investigating a possible modulating role for attention in biological motion processing in ASD.
Methods

We employed high-density electroencephalographic (EEG) recordings while participants observed point-light displays of upright, inverted and scrambled biological motion under two task conditions to explore spatiotemporal dynamics of intentional and unintentional biological motion processing in children and adolescents with ASD (n=27), comparing them to a control cohort of neurotypical (NT) participants (n=35).
Results

Behaviorally, ASD participants were able to discriminate biological motion with similar accuracy to NT controls. However, electrophysiologic investigation revealed reduced automatic selective processing of upright biologic vs. scrambled motion stimuli in ASD relative to NT individuals, which was ameliorated when task demands required explicit attention to biological motion. Additionally, we observed distinctive patterns of covariance between visual potentials evoked by biological motion and functional social ability, such that Vineland Adaptive Behavior Scale-Socialization domain scores were differentially associated with biological motion processing in the N1 and P2 periods in the ASD and NT groups, respectively.
Limitations

The cross-sectional design of this study does not allow us to definitively answer the question of whether developmental differences in attention to biological motion cause disruption in social communication, and the sample was limited to children with average or above cognitive ability.
Conclusions

Together, these data suggest that individuals with ASD are able to discriminate, with explicit attention, biological from non-biological motion but demonstrate diminished automatic neural specificity for biological motion processing, which may have cascading implications for the development of higher order social cognition.
The Impact of Sustained Metformin use on Survival in Diabetes Patients of Operable Colorectal Cancer: A Nationwide Cohort Study
Authors: Chu Ping-Teng , Chuang Tzu-Jung , Wu Tung-Ho , Huang Wei-Chun , Wang Jui-Ho
Published: October 2021

BackgroundColorectal cancer is one of the most common cancers in the Western world and in Taiwan and the diabetes has been proven as an independent risk factor for incidence. Metformin, the drug of choice for the therapy of type 2 diabetes, has been shown to reduce the risk of developing colorectal cancer. Our study was investigated the impact of continuous use of metformin on the survival of diabetic patients after surgery for colorectal cancer.MethodsThis study identified 12,512 patients with colorectal cancer and type 2 diabetes who underwent curative surgery between 2000 and 2012 were collected from the Taiwanese population-based National Health Insurance Research Database. A total of 6,222 patients were included in the matched cohort, to adjust for differences in baseline variables. Time-dependent covariates in the cox proportional hazard model was used to examine the impacts of metformin use on survival.Results The average duration of follow-up was 49.4 months in the Metformin use group and 53.7 months in the non-Metformin use group. The Cox proportional hazard model revealed that continuous metformin use post operation was associated with 5-year survival benefit (HR: 0.23, 95% CI: 0.20-0.26). Furthermore, continuous metformin use also showed a benefit of decreasing liver metastases (HR: 0.83, 95% CI: 0.71-0.97).ConclusionsSustained Metformin use is associated with a significant survival benefit in diabetic colorectal cancer patients after operation, suggesting a potential anti-tumorigenic effect. Moreover, there was also a benefit of decreasing liver metastases in patients who received continuous metformin use.
Implementation Research for the Evaluation of the Child Health Education and Surveillance Tool Application: A Randomized-Controlled Trial
Authors: Westgard Christopher M , Orrego-Ferreyros Luis A.
Published: October 2021

When community health workers (CHWs) are effective, they can help teach essential knowledge of healthy child rearing practices in their communities. An effective mHealth tool can potentially improve the performance of CHWs and create greater child health and development outcomes. The Child Health Education and Surveillance Tool (CHEST App) was developed and implemented in a CHW program in the Amazon of Peru to improve CHW performance and early childhood development. The intervention was developed and implemented with the guidance of several implementation research tools. This study presents the results of the intervention METHODSThe CHEST App intervention was evaluated using an effectiveness-implementation hybrid type 2 study design. A group of communities (8) in Loreto, Perú were matched by propensity scores and then randomly assigned to an arm of the study. The implementation outcomes were evaluated with a mixed-methods approach to how well the intervention was installed into the local CHW program. The effectiveness of the intervention was determined by assessing knowledge scores, hemoglobin gm/dL, early childhood development motor scores and cognitive scores. An independent samples t-test and one way ANOVA analysis were conducted with each intervention outcome to assess differences between the intervention and control groups. The results of the study are presented within the framework of the Implementation Research Logic Model. RESULTSThe COVID-19 pandemic created significant interruptions in the intervention, significantly decreasing the dosage of the intervention received by the participants. However, the group of caregivers that received home visits with the CHEST App had significantly higher knowledge scores (+1.26 standard deviations) than those in the control group (t(184)=-4.39, p<0.001). The intervention group did not display significant differences in hemoglobin levels and early childhood development scores. Implementation of the CHEST App intervention was successful with high degrees of acceptability, adoption, and fidelity. However, adoption and fidelity of the surveillance function of the CHEST App by program coordinators was not achieved. CONCLUSIONThe CHEST App intervention is a promising tool to improve the performance of CHWs during their home visits and their ability to teach caregivers healthy child rearing practices. Trial RegistrationTrial registered on 11/29/2018 at https://doi.org/10.1186/ISRCTN43591826.
Health effects of PM2.5 constituents and source contributions in major metropolitan cities, South Korea
Authors: Kim Sangcheol , Yang Juyeon , Park Jieun , Song Inho , Kim Dae-Gon , Jeon Kwonho , Kim Ho , Yi Seung-Muk
Published: October 2021

South Korea is one of the East Asian countries suffering severe ambient PM2.5 pollution which has been continuously reported to a risk factor driving both death and disability in many parts of the world. We investigated the associations of cause-specific mortality with both PM2.5 chemical constituents and source contributions in four metropolitan cities, namely Seoul, Daejeon, Gwangju and Ulsan, by applying the generalized linear model (GLM) to the results of the positive matrix factorization (PMF) modeling. The cities represent each of four air control zone designated as of April 2020 by the special law for controlling air pollution on a regional basis in South Korea. We found that that the interquartile range (IQR) increase in the concentration PM2.5 chemical constituents largely increased the relative risk (RR) of mortality, whereas the significance and strength of the associations were different among the cities. In addition, the effects of unit increase in source contributions also differed depending on regions. In conclusion, the results of this study suggest the PM2.5 compositional characteristics may have influenced the heterogeneous health of PM2.5 exposure among the cities. Therefore, the plans and policies based on the regional characteristics of PM2.5 composition and health risk need to be implemented along with the reduction of total mass concentration of PM2.5 for mitigating adverse health effects efficiently from a perspective of public health.
Improved Spin-orbit Torque Induced Magnetization Switching Efficiency by Helium Ion Irradiation
Authors: An Suhyeok , Baek Eunchong , Kim Jin-A , Lee Ki-Seung , You Chun-Yeol
Published: October 2021

Increasing the efficiency of spin-orbit torque (SOT) is of great interest in spintronics devices because of its application to the non-volatile magnetic random access memory and in-logic memory devices. Accordingly, there are several studies to alter the magnetic properties and reduce the SOT switching current with Helium ion irradiation, but previous researches are focused on its quantitative changes only. Here, the authors observe the reduction of switching current and analyze the origins of Helium ion irradiation induced SOT switching current reduction. The first is from improved spin Hall angle caused by the resistivity change of heavy metal layer and second is from the reduction of surface anisotropy energy at interface between heavy metal and ferromagnet. The result shows that switching current is reduced about ~30.3% at dose of 30 ions/nm2 and relevant parameter change is shown as improved spin Hall angle from 0.096 to 0.132 and reduced anisotropy field from 13.7 to 8.5 kOe. Altogether, the power consumption ratio is calculated based on the derived parameter and result shows that requiring power reaches only 56.0% at 30 ions/nm2. This analysis suggests that more efficient SOT device engineering is possible by Helium ion irradiation.
Perspectives of Lipid Extraction By Biomass Stages of Microalgae Aphanothece Halophytica Developed in Business Scale
Authors: Miriam L. R. Monisha , Kings Ajith J , Raj R. Edwin , Shyam K. Prakash , Viswanathan M. Adhi
Published: October 2021

Worldwide, people are accepting a sustainable, renewable and economical source for biofuel production without affecting the environmental concerns. Microalgae can overcome problems with reasonable solutions along with higher lipid content, carbon neutrality, biomass productivity and utilization of feed supplements. Picking a distinctive strain is vital and the value depends on its micro, macro nutrients and its photosynthesis efficiency. Extracting oil from the different phases of microalgal biomass is a tedious process. Presently, halophilic Aphanothece halophytica was mass cultivated in raceway ponds using organic and inorganic nutrients. Microalgal biomass was harvested using novel organic flocculant and oil extraction was done through wet and dry basis based on solvent polarity. The process parameters were optimized for maximum lipid productivity using RSM and the empirical model was significantly analysed by analysis of variance. In wet basis, maximum lipid yield was 29.3%, where the reaction temperature, reaction time, biomass-to-solvent ratio and mixing intensity are 68ºC, 190 min, 9:1 and 300 rpm respectively. In dry basis, lipid yield 27.5% was achieved using 12:1 biomass-to-solvent ratio and mixing intensity was 300 rpm for 190 min at 68ºC. Then, the lipid was characterized by GCMS to identify the fatty acid composition to identify the right combination of fatty acid profile for further studies.
GRHL2 is a Candidate Prognostic and Immunotherapy Biomarker in Breast Cancer
Authors: Bai Xiaoyu , Li Yue , Li Yanlei , Li Fan , Che Na , Ni Chunsheng , Zhao Nan , Zhao Xiulan , Liu Tieju
Published: October 2021

Background:Breast cancer (BC) is the most frequent malignancy in women worldwide and the leading cause of female cancer‐associated death in the world. Thus, we need to identify new biomarkers to predict the prognosis of BC. In mammals, the Grainyhead-like (GRHL) family of transcription factors has three members, called Grainyhead-like 1 (GRHL1), Grainyhead-like 2 (GRHL2) and Grainyhead-like 3 (GRHL3). GRHL2 contributes to epithelial morphogenesis and differentiation.Materials & Methods: In this study, we explored the expresstion of GRHL2 across multiple databases, including Oncomine, the Human Protein Atlas (HPA), UALCAN, and the Cancer Cell Line Encyclopedia (CCLE). PrognoScan, GEPIA and Kaplan-Meier plotter were utilized to analyze the prognostic value of GRHL2 in certain cancers. Based on TCGA data, a receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performance of GRHL2 expression. Using the GEPIA and TIMER databases, we investigated the correlations between GRHL2 expression and immune cell infiltration in breast cancer. In addition, the gene set enrichment analysis was performed to unveil the potential molecular mechanism of GRHL2 promoting breast cancer aggressiveness by using LinkedOmics and METASCAPE. Results: We demonstrated that tumor tissue had the higher expression level of GRHL2, compared with that in normal tissue. High expression of GRHL2 was associated with worse prognosis of breast cancer patients. ROC analysis indicated that GRHL2 had significant diagnostic value. Importantly, there were significant positive correlations between GRHL2 expression and immune infiltrates, including CD8+ T cells and macrophages in breast cancer. GRHL2 expression is regulated by methylation. Furthermore, KEGG and GO analysis showed GRHL2 related signaling pathways in breast cancer are related to tumor cells proliferation, invasion and angiogenesis. Conclusion:In summary, we demonstrate that GRHL2 can be used as a prognostic and immunotherapy biomarker for breast cancer.
Ruang Publik dan Paradigma Pendidikan Integralistik: Dari Interaksi Komunikatif Menuju Implementasi Kurikulum Berbasis Perjumpaan
Authors: Alexander Michael
Published: October 2021

AbstractThe public sphere is a meeting space. Various identities meet and interact. Each carries its pattern: instrumental-hierarchical, strategicmonological, or mutual-communicative. Equality in the last pattern is the basis for building relationships that are oriented towards realizing common goals which are formulated from the synthesis of ideas. This research shows that there is a gap between the idea of inter-particularities equality and the tendency of the respondents to prioritize group identities over efforts to create common welfare. This gap can be traced back to the design of the lectionary sermon which found a lack of discussion on the themes of the public space. Therefore, the author proposes analternative paradigmatic model that integrates all personal dimensions into the global-public dimension. A participatory approach that raises experiences in the context of community life is used as a starting point to mobilize the active participation of the people in testing the sermons relevance in the public space.

AbstrakRuang publik merupakan ruang perjumpaan. Berbagai identitas bertemu dan berinteraksi. Masing-masing membawa polanya: instrumental-hierarkis, strategis-monologis, atau mutual-komunikatif. Kesetaraan dalam pola terakhir merupakandasar untuk menjalin relasi yang berorientasi pada upaya mewujudkan tujuan bersama yang dirumuskan dari sintesa gagasan-gagasan. Penelitian ini menunjukkan terdapatnya kesenjangan antara gagasan kesetaraan antarpartikularitas dengan kecenderungan umat responden yang mengutamakan identitas kelompok di atas upaya mewujudkan kemaslahatan bersama. Kesenjangan tersebut selanjutnya dirunut kembali pada rancangan khotbah leksionari dan dijumpai minimnya pembahasan mengenai tema-tema ruang publik. Oleh sebab itu, penulis mengusulkan sebuah model paradigmatik alternatif yang mengintegrasikan seluruh dimensi personal ke dalam dimensi publik global. Pendekatan partisipatori yang mengangkat pengalaman dalam konteks hidup bermasyarakat dipergunakan sebagai titik tolak guna memobilisir partisipasi aktif umat dalam mengujicobakan relevansi berita mimbar di ruang publik.
COURSE OF HOSPITALIZATION & OUTCOME OF COVID-19 ADMISSIONS DURING SECOND WAVE OF PANDEMIC IN A TERTIARY CARE INSTITUTE, BIHAR, INDIA
Authors:   Junior Resident, Department of Trauma and Emergency All India Institute of Medical Sciences, Patna., Prakash Suman , Rao U.R Rajath ,   Senior Resident, Department of Community and Family Medicine, All India Institute of Medical Sciences, Patna.
Published: October 2021

Introduction: With emergence of new strains of SARS-COV-2 and increased transmission of the virus, it is necessary to study the socio-demography, epidemiology, clinical course, outcome of Covid-19 patients to add to the existing pool of literature and understand the lacunae behind its epidemiology. Methods: A record based observational study done among 100 COVID-19 admissions of second wave using a pre designed Performa containing details regarding covid-19 admissions and results tabulated and necessary statistical tests applied and significance attributed to P<0.05. Results: Among 100 admissions, Median age was 56.5 (IQR:40-65) years,12% having history of contact with COVID-19 cases, coughbeing the common symptom(84%) and 61% having one or more comorbidity with median 10 days of hospital stay, 59% requiring oxygen treatment,14% required ICU care and 7(7%) reaching primary outcome(expired). Conclusion: Cough is the most common presenting symptom with more admissions in middle aged-elderly.One requiring ICU, Artificial ventilation, Intubation and Oxygen supplement had more mortality than others.
CORRELATION OF PULMONARY CAPILLARY WEDGE PRESSURE CALCULATED BY ECHO-DOPPLER WITH INVASIVE MEASUREMENT BY SWAN GANZ CATHETER IN POST CORONARY ARTERY BYPASS GRAFT PATIENTS
Authors: Rajge Harshad , Kale Keshav , Kane G.R. , Ghosh Roy Falguni
Published: October 2021

The present study was conducted to correlate PCWP estimated by Doppler Echocardiography with that obtained by Swan-Ganz catheter in patients with post coronary artery bypass graft surgery and to evaluate the feasibility and accuracy of Doppler Echocardiographic data. The present study provides evidence that in patients with coronary artery disease who underwent elective CABG surgery, PCWP can be reliably and accurately estimated by combining Doppler Echocardiographic variables of mitral flow and Tissue Doppler imaging and the relationship between E/Ea ratio and measured PCWP by Swan Ganz catheter was the strongest of all Doppler variables determined.
Fotovoltaik Panel ve Batarya Entegre Sistemler için Yeni Bir Interleaved Tabanlı Çok Portlu İzole DA-DA Dönüştürücü Analizi
Authors: SAVRUN Murat Mustafa , ATAY Alihan
Published: October 2021

Bu çalışmada, fotovoltaik (FV) panel ile çalışan ve batarya destekli sistemler için etkin bir kontrol yapısına sahip interleaved tabanlı çift yönlü çok portlu izole yeni bir DA-DA dönüştürücü önerilmektedir. Önerilen dönüştürücü, üretim/depolama/yük birimleri arasındaki optimum güç akışını denetlemek için tasarlanmıştır. Tasarlanan sistemde, FV panel ve batarya arası güç transferi interleaved DA-DA dönüştürücünün sol kol anahtarlarının kontrolü ile sağlanırken, enerji üretim/depolama birimleri ile yükler arası güç transferi ilgili devrenin sağ kol anahtarlarının kontrolü ile sağlanmaktadır. Yük tarafının izolasyonunu sağlayan yüksek frekans transformatörünün (YFT) ikincil tarafında bulunan iki yarım köprü devresi ile birbirinden bağımsız kontrol edilebilen ve farklı gerilim seviyelerine sahip iki port oluşturulmaktadır. Önerilen dönüştürücüde portlar arasındaki güç akışı kontrol döngüleri arasında yumuşak geçiş yapabilen çok döngülü bir kontrol şeması tarafından gerçekleştirilmektedir. Önerilen çok portlu dönüştürücünün uygulanabilirliğini ve etkinliğini doğrulamak için, PSIM programında simülasyon çalışmaları gerçekleştirilmiştir. Önerilen dönüştürücünün performansı farklı ışınım ve yüklenme durumları gibi dinamik koşullar altında analiz edilmiştir. Güç akış yetenekleri ve yüksek verimlilik değerleri (>%98) önerilen dönüştürücünün uygulanabilirliğini ve etkinliğini doğrulamaktadır
Afşin-Elbistan Termik Santral Külünün Standarda Uygun Hale Getirilmesi ve Beton Katkısı Olarak Değerlendirilmesi
Authors: TEMİZ Hüseyin , ELBİSTAN Kadir , PAKÖZ Betül
Published: October 2021

Türkiye’de sanayinin gelişmesi ve yaygınlaşması için enerjiye gereksinim vardır. Bu nedenle enerji üretiminin artırılması, enerjiden tasarruf sağlanması ve binaların yalıtımına önem verilmesi, atık maddelerin değerlendirilmesi gibi konuların önemi giderek artmaktadır. 2019 yılı verilerine göre Türkiye’de elektriğin yaklaşık %57,8’i fosil yakıtlardan üretilmektedir. Fosil yakıtların yaklaşık %65’ini kömür oluşturmaktadır. Kahramanmaraş Afşin-Elbistan Termik Santrali, linyit kömürü ile elektrik üreten santrallerden biridir. Afşin-Elbistan Termik Santrali’nde yılda yaklaşık iki milyon ton uçucu kül üretilmekte ve bu külün çok azı kullanılmaktadır. Bu uçucu külün yeterince kullanılmamasının nedeni; kimyasal yapısının standartların öngördüğü kriterlere uygun olmamasıdır. Atık külün depolama sorunu yanında, çevrenin kirlenmesine önemli derecede etkisi de bulunmaktadır. Diğer yandan endüstriye kazandırılması halinde ülke ekonomisine önemli oranda katkı sağlaması bilinen bir gerçektir. Bu deneysel çalışmada, Kayseri bimsi, cam atığı tozu, az oranda kolemanit ilaveleriyle Afşin-Elbistan Termik Santrali uçucu külü (AEUK) standarda uygun hale getirilmiştir. Basınç dayanımı, priz süresi, hacimsel genleşme, donma-çözülme gibi deneyler yapılmıştır. Katkı maddeleri sayesinde, AEUK’nın betonda kullanılabileceği ortaya çıkarılmıştır.
Exploring the Misalignment between Business and Information Technology on the Implementation of Balanced Scorecard: Case Study of State-Owned Telecommunication Companies in Indonesia
Authors: Sundoro Hardy , Wandebori Harimukti
Published: October 2021

Many organisations around the world have faced misalignment in attaining the alignment between business and IT. The positive effect of alignment on overall company success has been focused on previous research. On the other hand, the misalignment in the implementation of a balanced scorecard was primarily unexplored. This study aimed at identifying and evaluating the factors that contribute to a misalignment of businesses and IT. The case study methodology is conducted in two state-owned telecommunication companies in Indonesia. The telecommunication industry’s selection as the case study is because of their nature closely related to technology development and implementation. Five semi-structured interviews, field notes and business records are used to produce the data, which have been thematically analysed and further follow by cross-case analysis to compare the thematic analysis result from each company. This study has resulted in 12 factors of misalignment between business and IT that can inhibit achieving alignment in implementing a balanced scorecard. The main findings showed that human factors, enterprise architecture, and IT project implementation factors could be three main source themes that can potentially contribute to misalignment. The findings may allow researchers to devise frameworks for how misalignments can be minimised to align business and IT better. This finding also useful in practice for companies that are seeking to achieve business-IT alignment by focusing on human factors, enterprise architecture factors, and IT project implementation factors.
Water quality deterioration of reclaimed water produced by reverse osmosis process in large pilot-scale distribution systems of different pipe materials
Authors: Xu Xiyan , Cui Yong , Wang Zhangqing , Zhang Hongyu , Li Caifeng , Yu Kanghua
Published: October 2021

This work reports the effects of five pipe materials on reverse osmosis (RO)-reclaimed water quality in a large pilot-scale distribution system. These materials includes cast iron (CI), cast iron with cement-mortar lining (CML), stainless steel (SS), PVC, and PE. Long-term running tests for 96 hours are conducted with water quality parameters monitored online and analyzed offline. The results showed that red water appeared in CI pipe due to iron corrosion. The pH and TDS increased during the long-term test. Alkali–silica reaction in CML pipe led to a high increase of pH from 6.3 to 11.4, and TDS from 51 to 230 mg/L. Water quality deterioration was not observed in SS, PVC, and PE pipes. Residual chlorine decay occurred in all the five material pipes with the decay rate order of CI ≫ CML > SS ≈ PVC ≈ PE. Ion concentration variation was also followed during the tests. Fe and Mn ions were detected in CI pipe and Ca, Si, Al, and S were detected in CML pipe. No detectable ion release was found in SS, PVC, and PE pipes. A kinetic model was postulated for the detected ion release with the mechanisms discussed in-depth.
DESTRUKTURIZATION AS THE MECHANISM OF CREATION OF ABSURDITY IN RUSSIAN DRAMA OF ABSURDITY OF THE END OF THE XX-TH CENTURY (COMMUNICATIVELY-KOGNITIVE ASPECT)
Authors:   Astrakhan State University, MARINA A. GOLOVANEVA
Published: October 2021

The subject of research in the work is the language and speech means of creating absurdity. They come to light within the framework of the destructuring mechanism in the texts of the Russian drama of the absurd at the end of the twentieth century. As a result, it is concluded that there is a significant communicative and cognitive potential of the speech constructions of the absurd, participating in the objectification of the author's creative consciousness. The author's communicative tactics, active linguistic means: inserted words and nonsense words, telegraphic style, chopped prose, ignoring punctuation marks, forcing professionalism and one-piece nominative sentences, the absence of anaphoric and cataphoric connections within the utterance are noted. The analysis uses the techniques of the author's cognitive-discursive method.
SEMANTIC PECULIARITIES OF VOCABULARY USED IN PRESCRIPTIONS OF PREPARATION OF NATIVE MEDICAL MEANS
Authors:   Astrakhan State Medical University, GUL'SANIYA N. NOSENKO , TAT'YANA S. KIRILLOVA ,   Astrakhan State Medical University
Published: October 2021

The article deals with some peculiarities of common vocabulary terminological specialization included in native and traditional language vocabulary and procedural field of preparation of native medicinal means using native medical prescriptions. The author stresses the importance of component analysis method in seme semantic content study.
THE VARIABILITY OF EXPRESSION OF SUBORDINATE RELATIONS IN ANATOMICAL TERMS
Authors:   Astrakhan State Medical University, TATIANA A. TKACHEVA
Published: October 2021

The article reveals the patterns of using inconsistent and consistent attribute in the structure of the Latin anatomical multi-word term and in its equivalents in other languages. In search of criteria for choosing one or another method of determination, processes of lexicalization of a complex term, semantic analysis of components of a multi-word term are considered, contrast analysis is carried out to compare the Latin term with its equivalents in other languages. On the basis of the analysis of the International Anatomical Terminology, cases of variability of the same term with consistent and inconsistent attribute are considered. Professional language usage is considered as one of the reasons for the rare interchangeability of consistent and inconsistent attribute denoting the same anatomical object. Based on the theory of psychosystematics, the author concludes that there is a difference in the semantic perception of variants of the two-word term with consistent and inconsistent attribute in connection with the different thought mechanism of the incident in the formation of the noun and adjective.
AGGRESSIVE METAPHOR AS AN EMOTIONALLY EXPRESSIVE STYLISTIC MEANS OF FORMING NEGATIVE PUBLIC OPINION (BASED ON THE MATERIAL OF FRENCH MEDIA ARTICLES DEVOTED TO THE "YELLOW VESTS" MOVEMENT IN FRANCE)
Authors:   Astrakhan State University, YULIYA V. CHUDINOVA , DIANA A. POLEGOSHKO ,   Astrakhan State University
Published: October 2021

This article is devoted to the study of "aggressive" metaphors in the French media. The main concept of the work is to study the conceptual metaphors proposed by the American linguists J. Lakoff, M. Johnson and the Russian linguist, A.P. Chudinov using the theoretical material of cognitive linguistics and stylistics. From the point of view of the theory the key issues are the consideration of the concept of metaphor in the framework of stylistics and cognitive linguistics, the study of the structure of conceptual metaphors: conceptual domains, the principles of metaphorical transfer, frame-slot mechanisms, stylistic functions, the study of the role of this type of metaphor in the journalistic text, the study of their stable classification and basic stylistic characteristics. The analysis of the structure of conceptual metaphors is necessary for understanding the process of metaphorization and for studying the principles of forming a negative opinion of the author. All the studied examples relate to certain metaphorical concepts that express an "aggressive" metaphor. The authors also emphasize the mechanisms of speech aggression in metaphor. The research is based on the material of political articles devoted to the «yellow vests movement in France, taken from the well-known weekly magazines "Le Monde" and "Le Point".
FABULOUS TRADITION IN THE LYRICS OF V. NARBUT
Authors:   Astrakhan State Medical University, KSENIA N. GUSHCHINA
Published: October 2021

The article is devoted to the analysis of the fairy tale manner of narration in the poetic heritage of V. Narbut. The researched author, in the context of the main poetic tendencies of Russian literature at the turn of the 19th and 20th centuries, in search of new forms of narration, actively rethinks and includes existing narrative models in his work. The tale in this aspect provides great opportunities for poetic representation of the author's intentions. This work reveals the main stylistic, figurative and lexical signs of the tale, as well as the ways of their embodiment and refraction in the artistic picture of the poet's world in line with the poetic quests of acmeism.
ACTIVITIES OF THE EMERITAL CASH REGISTER OF THE RUSSIAN MARITIME MINISTRY UNDER THE MANAGEMENT OF M. A. PESHCHUROV
Authors:   Voronezh State Agrarian University named after Peter I, NADEZHDA I. TYURINA
Published: October 2021

The article is devoted to the aspects of the activity of the Emerital Pension Fund of the Russian Maritime Ministry during the management of its affairs by the Head M. A. Pevurov. His biography is briefly described in this scientific work. Special attention is paid to the problems of the Emerital Cash Register of the Russian Maritime Ministry, the solution of which was necessary to ensure the financial viability of this organization. It was thanks to the fruitful work of M. A. Peshchurov in the role of the Head of the Cash Register that differences were discovered in time in the real indicators of its activity in comparison with theoretical calculations. Of course, it took time to resolve these issues, but despite these and other difficulties, the Cash Register not only continued its activities for the payment of pensions and benefits, but also provided certain benefits to its participants. During the 24-year management of M. A. Peshurov's affairs of the Emerital Cash Register, this institution reached the highest peak of its activity and then, almost suddenly, found itself on the edge of insolvency. However, in this disorder of the Cashier's affairs, the main role was played by reasons that did not depend on the Manager. Further research has shown that the real reason for the decline of the Pension Fund was solely in the very emerital principle that underlay the structure of the Emerital Pension Fund.
ELECTORAL RIGHTS FOR FOREIGNERS: RUSSIAN AND FOREIGN EXPERIENCE
Authors:   Astrakhan State University, EKATERINA V. KUDRYASHOVA , EKATERINA P. MARMILOVA ,   Russian Political Science Association, MALVINA R. KARABASHEVA ,   Financial University under the Government of the Russian Federation
Published: October 2021

The article examines the Russian and foreign experience of granting electoral rights to foreign citizens. As part of the study of the Russian peculiarities of electoral law, it was noted that at the present stage, foreigners could vote only at the municipal level on a par with the citizens of the Russian Federation, however, an important condition is the presence of concluded bilateral international treaties. In addition, foreigners must reside in the territory of a municipality for a long period. In addition, it was noted that in the post-Soviet space, the adjacent rules of permission to elect and be elected, as in the case of Russia, are generally observed. Because of the study of the characteristic features of the electoral law of foreign states, it was revealed that in most democratic European states, foreigners are granted active suffrage in local elections, however, only subject to the relevant requirements enshrined in the laws of each country. Despite this, at the present stage there are states that allow foreign citizens to take part in federal elections. Thus, New Zealand was named one of the most inclusive countries providing broad electoral rights.
PROBLEMS OF RELIGIOUS TRANSGRESSION ON ENGLISH INTERNET FORUMS
Authors:   Astrakhan State University, EKATERINA V. KUDRYASHOVA
Published: October 2021

The subject of the article is the cases of a change of religion and the possibility of such a change, discussed on Internet forums. The article focuses on the definition of this phenomenon and the identification of its key characteristic features. At the same time, it is noted that within the framework of religious themes, forums now allow you to move from traditional means of providing information to building a vertical of communication between users. The situation with the discussion of such topics on foreign Internet forums is somewhat different from Russian trends and has its own characteristics. In foreign forums, the genre of "personal testimony" is increasingly used, which consists in detailed stories about how a person turned to another God or turned away from him altogether, thereby accomplishing a religious transgression. The main reason that sounded in the personal testimonies that prompted the transgression is that the person learned something that he did not know before, and that turned out to be incompatible with his religious picture of the world. Personal stories play an additional role - to cheer up those who have lost their faith, but do not dare to declare it openly. Statements of members of the forum confirm that Network atheism continues to gain momentum, revealing the conflict of the transition process
SOME ISSUES OF ECONOMIC ACTIVITY OF THE SALACHIK SUBURBS IN THE SECOND HALF OF THE XIX - BEGINNING OF THE XX CENTURY (ACCORDING TO THE MATERIALS OF THE BAKHCHISARAY CITY ADMINISTRATION)
Authors:   Crimean Engineering and Pedagogic University named after Fevzi Yakubov, ELVIS E. OSMANOV
Published: October 2021

Study of the historical experience of the city government bodies and the inclusion of townspeople in the new socio-cultural reality is of undoubted scientific interest. This article examines certain aspects of economic and social development of the Salachik suburb in Bakhchisarai based on the analysis of documents from the funds of the State Archives of the Republic of Crimea. Russian historiography achieved certain progress in the coverage of individual quarters and prominent buildings of Salachik. At present research in this direction allows you to focus on previously unexplored issues. The purpose of this article is to examine the economic life of the inhabitants of the suburb in the second half of the ХIХ - early ХХ centuries. The author analyzed the experience of positive and negative interaction between municipal authorities and local residents who took an active part in the destiny of the city. This is illustrated by the example of issuing certificates for the restructuring of residential buildings, concluding lease transactions, solving problems of water supply and violation of city property rights. The author comes to the conclusion that certain success was achieved in solving the economic issues of the Salachik suburb during the specified period of time thanks to the activities of the City Council and private initiative.
THE CONCEPT OF THE PERFECT RULER IN A. FERDOWSI’S POEM “SHAHNAMEH”
Authors:   Lomonosov Moscow State University, GULNAR GOCHMURADOVA , ANNA V. MYRIKOVA ,   Lomonosov Moscow State University
Published: October 2021

The article presents a political and textological analysis of the concept of an “ideal ruler” in the poem “Shahnameh” by A. Ferdowsi. Political textology is a new discipline that arose as a synthesis of philology, history and political science, and it involves the study of a variety of sources, including those not directly related to political theory. In the scientific world the poem of Abulkasim Ferdowsi (940-1020) "Shahnameh" was studied mainly by philologists, historians and archaeologists, therefore the political and textological analysis of this monument of world culture seems to be very relevant for political science. Based on the poem, which is the pearl of world literature, and the works of modern researchers, the authors not only seek to consider the work from the viewpoint of political textology, but also set themselves the task of conceptualizing the socio-political ideas contained in it. The analysis of the poem "Shahnameh" showed that the meaning of power, which is a key category of political science, according to A. Ferdowsi is the establishment of the laws of truth and justice. The Creator gives the ruler the power to fight the forces of evil. If the sovereign forgets his mission, then he loses the grace of God, and, as a result, his power. Based on the political-textological analysis of the socio-political ideas expressed in the work “Shahnameh” in poetic form, it can be concluded that the best type of government for A. Ferdowsi is an enlightened monarchy. And the best state, in the poet's mind, is the state that affirms the law of the Creator. The “ideal ruler” in the poem “Shahnameh” by A. Ferdowsi must have four important characteristics: the ability to distinguish between good and evil, righteousness, valor and nobility. The article emphasizes that the stories of kings and warriors described in the “Shahnameh” can be considered the keys to understanding Iranian political culture. The object of the research is the poem "Shahnameh" by A. Ferdowsi, the subject is the concept of the "ideal ruler".