bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of 1,2-naphthoquinone derivatives as α-glucosidase inhibitors
Authors:   , Thi Trang
Published: April 2023

For a couple of decades the bioactivity of quinone has been considered as privileged structure-based drug design. In this research, 4-phenylamino, 4-alkylamino, 4-alkylphenylamino, 4-phenoxy and other derivatives of 1,2-naphthoquinone were synthesized, evaluated for their anti α-glucosidase activity and elucidated for their structure-activity relationship. The results indicated that multiple factors affecting to the α-glucosidase inhibition included π-π interaction, hydrophobic interaction and hydrogen bonding with the enzyme. In general, the main factor affecting the activity was the more favorable 1,2-dione production. The presence of electron withdrawing substituents on the phenyl ring and heteroatom linker bound to the quinone skeleton increased the activity. The most active compounds were 4-(4-nitrophenylamino)-1,2-naphthoquinone (29) and 4-methoxy-1,2-naphthoquinone (64) with IC50 value of 14.59 µM and 11.39 µM, respectively, which were better than current anti-diabetes drug, acarbose (IC50 = 93.63 µM).
Tetrabromomethane-mediated desulfurization for synthesis of isothiocyanates from amines
Authors:   , Techapanalai Saharat
Published: April 2023

Isothiocyanate considered as an important building block for pharmaceutical industry. Traditional methods for preparation of isothiocyanate involved the desulfurization of dithiocarbamate salt from amine using oxidizing agent. Although those methods are efficient, however, all of them require the use of toxic reagent, strong oxidizing agent, multiple step synthesis, harsh condition and large amount of metal catalyst. Therefore, in this research, we develop two mild methods  to synthesize isothiocyanates from amines using low toxic reagent. For the first process, we were able to demonstrate the use of photocatalyst, safranin O to convert dithiocarbamate salt of 4-bromoaniline into 4-brophenyl isothiocyanate in 48% yield in one-pot under white LED irradiation. For the second process, commercially and low toxic CBr4 was used for desulfurization process. Based on our optimize investigation, we found that the use of CBr4 1.5 equivalences in the presence of 3.0 equivalences of DBU as base in acetonitrile give the optimized condition. Under this condition, we were able to synthesize 32 examples of isothiocyanates in moderate to excellent yields. Moreover, we were able to extend this methodology to prepare unsymmetrical thioureas via the in situ generation of isothiocyanate in one-pot. The synthesis of isothiocyanates and unsymmetrical thioureas were able to prepare a one-gram scale in good yields. The mechanistic study revealed that CHBr3 and sulfur were detected by NMR and SEM/EDX. This evidence suggests that CBr4 act as an electrophile to induce the desulfurization process. The benefit of this reaction includes one-pot synthesis, open air condition and low toxic desulfurizing agent.
An assessment of root reinforcement on soil slope using centrifuge and numerical modelling
Authors:   , Prasetyaningtiyas Gayuh
Published: April 2023

The extreme rainfall as an effect of climate change has been considered as the main problem due to landslide hazard. The rainfall can trigger slope failure through the kinetic energy of raindrop and decreasing of soil resistance due to the increasing of pore water pressure. Vegetation is considerably as low cost and environmentally friendly slope reinforcement. The root specifically provides high contribution in strengthen the soil through the root-soil interaction. However, there is a gap between slope reinforcement by root modelling and field assessment result. The gap is an impact of indirect linked between laboratory modelling and existing vegetated slope behaviour. This study used actual live-plants root and rainfall simulation to demonstrate the effect of root on slope stability under the high rainfall intensity using centrifuge test. The pore water pressure and deformation were monitored during the centrifuge test. The results were verified by numerical analysis. The rainfall simulation was analysed by using transient modelling and parented with slope stability analysis. Meanwhile the deformation was simulated by using Geo-PIV. The result showed that root significantly increasing the slope endurance against slope instability provoked by rainfall. The vegetation provided additional soil hydro-mechanical properties and root system that help soil increases slope stability. Keywords: climate change, landslide, heavy rainfall, root reinforcement, centrifuge modelling.
Binary particle swarm optimization algorithm for optimization of steel structure
Authors:   , Chaiwongnoi Atitaya
Published: April 2023

This research studies on the performance of Binary Particle Swarm Optimization (BPSO) algorithm. The first part is finding the best inertia weight of BPSO from various types of inertia weight. The second part is optimizing the cross-sectional area of steel structures and topology of bracing system under vertical and lateral load. The structures studied in the research include unbraced frames and X-braced frames. Moreover, the braced frame also investigates the influence of the classification groups of elements. The elements are classified into finer groups than the original group. The design of the structure follows the AISC code. From the investigation in the first part, a constant inertia weight of 0.98 is the best. In the second part, minimum weights of unbraced frames using BPSO are the lowest weight, except three-bays, twenty-four stories frame. For braced frames with original grouping, all examples get a lower weight than the unbraced frames. For studying the influence of group, the results of the two examples are contradictory. One bay, ten stories frame with new group has a minimum weight less than the original while three-bays but twenty-four stories frame is opposite.
Turbulent flow of water-based algorithm in truss optimization
Authors:   , Khaing Saw
Published: April 2023

This thesis presents the novel Turbulent Flow of Water-based Optimization (TFWO) algorithm for the optimal design of structures under applied forces. The method has been inspired by the natural and random responses of vortices in rivers, seas and oceans. The design problem minimizes the total cost (viz., weight or volume) of the structure with the optimal distribution of its member sizes such that the safety and integrity of the resulting structure can be attained. It is formulated as the challenging nonlinear programming problem under the simultaneous ultimate strength and serviceability criteria. The proposed algorithm is encoded as a MATLAB code where the structure is discretized as a standard pin-connected truss. Various design benchmarks have been successfully processed by the TFWO approach. The accurate design solutions can be achieved at modest computing resources, where all constraints are strictly complied.
Effect of the robotic-assisted gait training device (Welwalk®) plus physiotherapy in improving the ambulatory function in sub-acute hemiplegic stroke patients: assessor-blinded, randomized controlled trial
Authors:   , Thimabut Natapatchakrid
Published: April 2023

Over the last decades, the effectiveness of robot-assisted gait training devices has been extensively studied. Welwalk® has been developed to support ambulatory functions in stroke patients based on motor learning theory.
Objective: To investigate the effects of Welwalk® plus physiotherapy versus physiotherapy alone, in improving ambulatory function in subacute stroke patients with hemiplegia.
Methods: The study was an assessor-blinded, randomized controlled trial. Twenty-six subacute stroke patients with hemiplegia were randomized and allocated into either the Welwalk group or control. All patients received 30 training sessions (5 days/week for six weeks) which included standard physiotherapy treatment (60 min) and ambulation training (60 min). In the ambulation training session, the Welwalk group received robotic training (40 min) and ground ambulation training (20 min). The control group received only ground ambulation training (60 min). The outcomes were assessed at the initial session, the end of the 15th and the 30th sessions. Comparisons within group and between the groups were conducted.
Results: The Welwalk group showed greater improvements from baseline than control in: (1) the Functional Independence Measure (FIM)-walk score, at the end of the 15th session (P = 0.012), (2) the efficiency of FIM-walk, at the end of the 15th session (P = 0.008), (3) walking distance in the 6-minute walk test (6MWT), at the end of the 15th session (P = 0.018), (4) the Barthel Index for Activities of Daily Living (ADL), at the end of the 30th session (P < 0.001), and (5) gait symmetry ratio, at the end of the 30th session (P = 0.044). Other gait parameters showed the tendencies of improvement in the Welwalk group, but there were no significant differences.
Conclusion: Welwalk® plus physiotherapy showed early improvements in walking ability and Barthel ADL index compared with ground level training plus physiotherapy in subacute stroke patients with hemiplegia.
A topical eye drop versus intra-meibomian gland injection of bevacizumab for meibomian gland dysfunction patients.
Authors:   , Tantipat Chitchanok
Published: April 2023

Purpose: To compare the efficacy and safety of topical bevacizumab eye drop versus intra-meibomian gland injection of bevacizumab when used with the standard lid hygiene in meibomian gland dysfunction (MGD) patients.

Methods: 60 eyes of 30 MGD patients with lid margin telangiectasia were randomized to receive 0.05% bevacizumab eye drop or single 2.5% intra-meibomian gland bevacizumab injection plus standard lid hygiene. The primary outcomes were telangiectasia grading and the computerized lid margin neovascularized area (LMNA). The secondary outcomes were the ocular surface disease index (OSDI) score, corneal staining, meibomian gland quality, meiboscore, conjunctival redness, fluorescein break up time (FBUT), noninvasive tear breakup time (NIBUT), lipid layer thickness (LLT), compliance of treatments, and adverse events (AE). All the parameters were re-evaluated before and until 3 months after treatment.

Results: A significant improvement in telangiectasia grading and LMNA, primary outcomes, were observed in injection group at month 3 (p<0.05) but LMNA was not apparent in the eye drop group. In the injection group, there were significant improvements in corneal staining, meiboscore, and FBUT compared with the eye drop group (p<0.05). Both groups showed significant improvements in OSDI score, corneal staining, MG quality, meiboscore, and conjunctival redness compared with pre-treatment. (p<0.05).

Conclusions: Both routes of intra-MG injection and eye drop bevacizumab administrations were safe and effective in reducing lid margin telangiectasia and signs and symptoms of MGD. Therefore, both routes of administration could be an alternative or adjunctive treatment with the standard lid hygiene for MGD patients.
เปรียบเทียบประสิทธิภาพระหว่างการใช้ยาไทโอโทรเปียมชนิดแฮนด์ดิเฮเลอร์(tiotropium handihaler) และการเพิ่มขนาดของยาพ่นสเตอรอยด์ (ICS)ในผู้ป่วยโรคหืดที่ยังคุมอาการไม่ได้ที่ใช้ยาพ่นสเตอรอยด์และยาขยายหลอดลมกระตุ้นเบต้ารีเซ็ปเตอร์ชนิดออกฤทธิ์นานขนาดปานกลางหรือขนาดสูง(moderate or high dose ICS/LABA) อยู่เดิม
Authors:   , อุ่นอนันต์ วิชญา
Published: April 2023

บทนำ: การรักษาโรคหืด GINA guideline แนะนำให้เพิ่มยาพ่นสเตอรอยด์ หรือเพิ่มยาพ่นไทโอโทรเปียมชนิดเรสปิแมท (TioR) ในผู้ป่วยโรคหืดที่ยังคุมอาการไม่ได้ในขั้น 4 และขั้น 5 ในประเทศไทยยาพ่นไทโอโทรเปียมชนิดแฮนด์ดิเฮเลอร์ (Tio) มีราคาถูกและสามารถเข้าถึงได้ในทุกสิทธิ์การรักษามากกว่า TioR จึงเป็นที่มาของงานวิจัยครั้งนี้ เพื่อเปรียบเทียบประสิทธิภาพระหว่างการใช้ Tio และการเพิ่มขนาดของยาพ่นสเตอรอยด์ ระเบียบวิธีวิจัย: การศึกษาชนิดวิจัยเชิงทดลอง คัดเลือกผู้ป่วยโรคหืดผู้ใหญ่ที่ยังคุมอาการไม่ได้ ในขั้น 4 และ 5 สุ่มเลือกผู้ป่วยเข้ากลุ่มศึกษา 1 คือ กลุ่มที่เพิ่มยา Tio 18 ไมโครกรัมต่อวัน หรือ กลุ่มศึกษา 2 คือ กลุ่มที่เพิ่มยาพ่นบูเดโซไนด์ (Bud) 400 ไมโครกรัมต่อวัน วัตถุประสงค์หลัก เพื่อเปรียบเทียบค่าการออกแรงหายใจออกสุดที่ 1 วินาทีที่ต่ำสุด (trough FEV1) ระหว่าง 2 กลุ่มศึกษาที่ 4 และ 12 สัปดาห์ ผลการวิจัย: ผู้ป่วยทั้งหมดในการศึกษาเป็นโรคหืดชนิด type 2 phenotype ผลการศึกษาหลัก พบว่าค่าความแตกต่างของ trough FEV1 improvement ที่ 4 และ 12 สัปดาห์ ของกลุ่ม Bud มีค่ามากกว่ากลุ่ม Tio อยู่ 68.1 มิลลิลิตร (95% CI -58.1 to 194.2, P value = 0.290) และ 41.4 มิลลิลิตร (95% CI -100.5 to 183.3, P value = 0.568) ตามลำดับ สรุป: ผู้ป่วยโรคหืดที่ใช้ยาพ่นสเตอรอยด์และยาขยายหลอดลมกระตุ้นเบต้ารีเซ็ปเตอร์ชนิดออกฤทธิ์นานขนาดปานกลางหรือขนาดสูงและมี type 2 phenotype ไม่พบความแตกต่างอย่างมีนัยสำคัญทางสถิติของ trough FEV1 improvement ระหว่าง 2 กลุ่มศึกษา
โครงการศึกษาการแสดงออกของไมโครอาร์เอ็นเอเพื่อทำนายภาวะการฟื้นตัวจากภาวะไตวายเฉียบพลัน
Authors:   , พูลเกิด ธนวรรธ
Published: April 2023

ความเป็นมา: การฟื้นตัวของไตมีความสำคัญต่อผลลัพธ์ของผู้ป่วยไตวายเฉียบพลัน จากข้อมูลปัจจุบันกล่าวถึงไมโครอาร์เอ็นเอมีบทบาทสำคัญในการควบคุมการแสดงออกยีน โดยส่งผลต่อการสร้างโปรตีนซึ่งจะสัมพันธ์ต่อการเปลี่ยนแปลงของเซลล์ในการตอบสนองภาวะไตวายเฉียบพลัน อย่างไรก็ตามยังไม่ทราบกลไกแน่ชัดของไมโครอาร์เอ็นเอกับการฟื้นตัวของไต วัตถุประสงค์: เพื่อค้นหาและทดสอบไมโครอาร์เอ็นเอในปัสสาวะและเลือดเพื่อใช้ทํานายการฟื้นตัวของไตจากภาวะไตวายเฉียบพลันแบบรุนแรง วิธีการ: การศึกษาการสังเกตแบบไปข้างหน้าในโรงพยาบาลจุฬาลงกรณ์ระหว่างเดือนมิถุนายน 2020 ถึงเดือนมกราคม 2021 โดยนำตัวอย่างจากปัสสาวะและซีรั่มที่เก็บจากผู้ป่วยที่มีภาวะไตวายเฉียบพลันขั้นที่ 3 หลังจากนั้นติดตาม 28 วันได้แบ่งผู้ป่วยเป็น 2 กลุ่มคือ กลุ่มที่มีการฟื้นตัวของไตและกลุ่มที่ไตไม่ฟื้นตัว โดยคำจำกัดความของภาวะการฟื้นตัวของไตมี 2 ข้อคือ ระดับครีเอตินินในเลือดกลับสู่ปกติและถ้ามีประวัติเดิมได้รับการล้างไตมาก่อนจะต้องหยุดล้างไตเป็นเวลาอย่างน้อย 14 วัน ซึ่งในขั้นตอนค้นพบได้ใช้นาโนสตริงเพื่อวิเคราะห์หาไมโครอาร์เอ็นเอที่ต้องการ หลังจากนั้นทำการทดสอบโดยการวัดหาระดับไมโครอาร์เอ็นเอด้วยวิธีปฏิกิริยาลูกโซ่พอลิเมอเรสแบบย้อนกลับ (Real-time polymerase chain reaction)  ผลลัพธ์: ในระยะค้นพบได้นำปัสสาวะ 10 ตัวอย่างและเลือด 9 ตัวอย่างโดยเก็บวันแรกของการศึกษาในผู้ป่วยที่มีภาวะไตวายเฉียบพลันขั้นที่ 3 ซึ่งนำมาวิเคราะห์เพื่อค้นหาไมโครอาร์เอ็นเอด้วยนาโนสตริง พบว่าระดับไมโครอาร์เอ็นเอในกลุ่มที่มีการฟื้นตัวของไตมีความแตกต่างอย่างมีนัยสําคัญกับกลุ่มที่ไตไม่ฟื้นตัว โดยการศึกษานี้ในปัสสาวะพบการเพิ่มขึ้นของ miR-556-3p (5.96, p=0.004), miR-1915-3p (5.87, p=0.02), miR-4284 (8.88, p=0.04) และการลดลงของ miR-32-5p (-2.29, p=0.005), miR-96-5p (-2.14, p=0.02), miR-556-5p (-5.61, p=0.04)  ขณะที่ในเลือดพบการเพิ่มขึ้นของ miR-499b-5p (3.6, p=0.04) และการลดลงของ miR-30a-3p (-2.18, p=0.0.002), miR-92b-3p (-6.29, p=0.001) และ miR-770-5p (-7.88, p=0.001) หลังจากนั้นนำไมโครอาร์เอ็นเอดังกล่าวเข้าสู่ขั้นตอนการทดสอบในผู้ป่วย 95 คน  พบว่า miR-556-3p ในปัสสาวะมีค่าสูงขึ้นอย่างมีนัยสําคัญระหว่างกลุ่มที่มีการฟื้นตัวของไตและกลุ่มที่ไตไม่ฟื้นตัว โดย miR-556-3p ในปัสสาวะมีค่าพื้นที่ใต้กราฟ 0.63 (95%CI; 0.51-0.76, p = 0.04)  และรูปแบบทางคลินิกเพื่อทํานายการฟื้นตัวของไตโดยมีการใช้คะแนนโซฟาที่ไม่ใช้ค่าที่เกี่ยวข้องกับไตมาคำนวณ ค่าความเข้มข้นเลือด และค่าครีเอตินินวันแรกของการศึกษาในผู้ป่วยที่มีภาวะไตวายเฉียบพลันขั้นที่ 3 มีค่าพื้นที่ใต้กราฟ 0.78 (95%CI; 0.68-0.89, p <0.01)  และเมื่อเรานำรูปแบบทางคลินิกร่วมกับ miR-556-3p ในปัสสาวะพบว่ามีค่าพื้นที่ใต้กราฟ 0.82 (95%CI; 0.72-0.91, p <0.01) สรุป: งานวิจัยนี้ได้ศึกษาไมโครอาร์เอ็นเอในผู้ป่วยไตวายเฉียบพลันเป็นครั้งแรกในกลุ่มที่มีการฟื้นตัวของไตเทียบกับกลุ่มที่ไตไม่ฟื้นตัว  พบว่า miR-556-3p ในปัสสาวะสามารถช่วยทํานายการฟื้นตัวของไตได้
Synthesis of alkane from lauric acid via electrochemical reaction in microreactor
Authors:   , Kiattinirachara Thantip
Published: April 2023

In the present work, decarboxylation of lauric acid to undecane was conducted by Kolbe electrochemical oxidation process in a microreactor.  The microreactor is widely used to study reaction kinetics as well as reaction mechanisms because of negligible heat and mass transfer resistances within the reactor.  The reactor is also very effective in the control of residence time. The 250-micron thick reactor was formed between graphite anode and stainless steel cathode sheets.  Reactive alkyl radicals were produced from the supplied electrical potential and their combination with proton produced alkane with the release of carbon dioxide.  The experiments were conducted to study the effect of residence time in the range of 100-400 s, and that of current density in the range from 6.67-37.04 ampere per meter squared.  Kinetic analysis and reaction behavior of the reaction was performed and presented in this work.
Catalytic conversion of chitin to lactic acid in hot-compressed water
Authors:   , Kun-asa Kodchakon
Published: April 2023

Chitin is the second most available polysaccharide after cellulose. Chitin and N-acetyl-D-glucosamine polysaccharide, can be converted to valuable products by using homogeneous catalysis, most of the chitin generated by food processing is treated as industrial waste.  For chitin conversion to useful chemicals has been investigated less than cellulose conversion. Therefore, in this research,  chitin conversion was investigated. The result was divided into four part. The first part, the result showed that ball milled pretreatment could increase the conversion of chitin, which indicated that the crystallinity of the chitin had been reduced by the ball milled pretreatment. In the second part, hot compressed water for chitin conversion without catalyst could be converted to other chemicals, but the product not selective with lactic acid.  Moreover, the effect of metal oxides was studied on chitin conversion into lactic acid. The result showed that MgO gave the high yield of lactic acid. 10.8 % yield of lactic acid was obtained by using MgO. The optimal condition for chitin conversion was  533 K reaction temperature 6 h reaction time and amount of MgO 1%wt. In the final part, the reaction mechanism was investigated. The base site of the catalyst played an important role in chitin conversion. The MgO catalyst could be recovered after the reaction and reused twice with no decrease in the lactic acid yield.
Tuning of metal ion selectivity by varying number of coordinating atoms in quinoline-derived fluorescent sensors
Authors:   , Hojitsiriyanont Jutawat
Published: April 2023

Both Cd2+ and Zn2+ are metal ions in group 12 elements with very different toxicities but similar binding properties to most organic and biological ligands. In this work, a series of quinoline derivatives were synthesized and studied with an aim for Cd2+ selective turn-on fluorescent sensors. The structures of the compounds were designed to systematically evaluate the effects of amino protons, number of N-coordinating atoms, quinoline/picoline moieties and substituents on the sensing properties. The association constants of all synthesized ligands were studied by UV-vis absorption titration in aqueous solution. The results revealed that the ligands having 6- and 4- donor atoms and absent of amino proton gave higher association constants for Cd2+ and Zn2+, respectively. L6, a ligand with 2 quinolines/2 picolines and 6 N atoms without amino proton, exhibited the highest Cd2+ sensitivity providing 118-fold of fluorescence enhancement (I/I0) at 480 nm and highest Cd2+/Zn2+ selectivity giving the Cd2+/Zn2+ association constant ratio of 32. L5, a tetradentate ligand containing 1 quinoline/2 picolines without amino protons showed highest association constant for Zn2+. The greater number of the quinoline units led to lower binding affinity and lower I/I0. Fluorescence quenching was even observed for ligands having solely 3 and 4 quinoline units (L12 and L13). Electron withdrawing substituents gave higher I/I0 but lower association constants. L6 was thus selected for further optimization as Cd2+ fluorescent sensor. The selectivity of Cd2+ detection by L6 was significantly improved by an addition of tripicolylamine (TPA), a non-fluorescent tetradentate ligand, that provided the limit of detection Cd2+ of 69 nM. In the fluorescence cell imaging, L6 could monitor Cd2+ in the concentration range of 0.1–10 µM.
Electrochemical reaction for direct synthesis of amides from aldehydes
Authors:   , Rerkrachaneekorn Tanawat
Published: April 2023

Conventional synthesis of amide involves the use of harsh condition, strong oxidizing agents, high value metal catalysts or multiple step synthesis of starting materials. To overcome these problems, in this research, we develop a mild electrochemical oxidative amidation directly from commercially available benzyl alcohols and aldehydes with amines. Optimization studies indicate that this electrochemical oxidative amidation can be proceeded via the use of sodium iodide as both electrolyte and mediator in aqueous solution performing in undivided cell at room temperature without additional additive. Under the optimized condition, we are able to perform electrochemical oxidative amidation of various benzyl alcohols and aromatic aldehydes with amines to prepare corresponding amide products (29 examples) in moderate to good yields. Moreover, our electrochemical oxidative amidation can be scaled to one gram synthesis. In addition, portable power charger can be used as alternative electrical source offering a convenience electrolysis setup. The mechanistic investigations reveal that molecular iodine is true oxidizing agent representing in indirect electrolysis fashion. The key benefits of this process are one-pot operation, open air condition, no requirement of external electrolyte, base and oxidizing agent providing an environmentally friendly process for amide synthesis.
Removal of arsenic from wastewater using mixed metal hydroxides and biopolymers
Authors:   , Ratroj Angchuda
Published: April 2023

Arsenic is one of the contaminants in wastewater which becomes a worldwide environmental problem. Therefore, several simple and cost-effective techniques have been developed for arsenic removal. This study reports on the removal of arsenic by coprecipitation method with variable combinations of the well-known metal salts, such as FeCl3 or AlCl3 with the environmentally friendly inorganic metal salts, such as MgCl2 or CaCl2, which is called “mixed metal system”. Moreover, for improving the low toxicity from sludge production, hence the coprecipitation techniques using mixed metal salts as coagulants combine with biopolymers (alginate or chitosan) as flocculants for arsenic removal were also studied. Under the optimum conditions, the results showed that the arsenic removal efficiency from simulated wastewater were about 95.4% and 96.8%, at pH9 by using 2.5MgFe/As and 2.5CaFe/As, consecutively. In addition, the arsenic removal efficiency of the combination between mixed metal and biopolymer systems were increased at pH9 for 0.7%w/v of alginate combine with 1.25MgFe/As, and it also increased at pH7 for 0.7%w/v of alginate combine with 1.25, 1.5 and 2.0CaFe/As system.
“A Questão Palestina”
Authors: Zolo Danilo
Published: April 2023

A questão palestina se arrasta há décadas sem solução. A ideia proposta pelas Nações Unidas, reafirmada pelas potências ocidentais, de dois Estados independentes e separados, nunca se concretizou. De fato, no território que já foi da antiga Palestina, existe um único Estado, o de Israel, fundado sobre a expulsão forçada dos palestinos que moravam há séculos ali. Mas essa não era, originariamente, a ideia do movimento sionista; por exemplo, Martin Buber, considerado o pai espiritual do novo Estado hebraico, era favorável a um único Estado em que judeus e palestinos convivessem. A recusa dessa proposta é o “pecado original” que impede uma solução justa e duradoura para a questão palestina.
STUDENT'S PERCEPTION OF TEACHER'S COMPETENCY IN LEARNING LOCAL LITERATURE IN ELEMENTARY SCHOOL
Authors: Ramadan Fitri , Widodo Arif
Published: April 2023

Teacher competence is related to the teacher's ability to design learning in the classroom. One material that has a high level of difficulty is local script material. In general, students have a low interest in learning literacy lessons. Based on preliminary research at one elementary school, it is known that students' interest in learning local characters is quite high. Armed with this initial study, it is necessary to conduct further research on how teachers design local script learning in the classroom so that learning is more interesting. This study aims to describe the competence of teachers in designing local script learning from the perspective of students. The research was designed in a quantitative descriptive form with the category of survey research. The instruments used are questionnaires and interview guidelines. The data obtained were analyzed using descriptive statistics. The research location is SDN Rada, Bima Regency. The subjects of this study were students of class V totaling 30 students. The results of this study indicate that teachers have good competence in the perspective of students. Students feel happy with the varied and fun learning models. Students' perception of teacher competence in teaching is what drives students' interest in learning to be higher.
THE EFFECT OF ONLINE LEARNING (WHATSAPP) AND STUDENTS INDEPENDENT ON THE LEARNING OUTCOME OF SOCIOLOGY AT SMAN 1 KUPANG
Authors: Nahak Yanuaria Marsela
Published: April 2023

The purpose of this study was to determine the effect of WhatsApp Online Learning Media and the outcome of student independence Learning at SMA Negeri 1 Kupang. The location of this research was SMA Negeri Kupang. The informant determination technique used was purposive sampling. Informants in this study were students of class X SMA Negeri 1 Kupang. This research uses several techniques such as questionnaires and documentation. The data technique in this research is the validity test and the rehabilitation test. The data analysis stage begins with validity and reliability tests and continues with descriptive analysis and inferential statistical analysis consisting of classical assumption tests, multiple linear regression analysis, statistical hypothesis testing, determination of correlation coefficient values, and determination of the coefficient of determination (R2). The results of this study conclude that WhatsApp online learning media and student independence have a positive and significant influence on sociology learning outcomes of class X at SMA Negeri 1 Kupang. This is evidenced by the test results, where the significance value of the WhatsApp online learning media variable (X1) and student independence (X2) is 0.000 or less than the alpha level used, which is 0.05 (5%).
IMPLEMENTATION OF MULTICULTURAL-BASED LEARNING AT SMA NEGERI 8 KUPANG
Authors: Mangmani Poas
Published: April 2023

This study aims to determine the implementation of multicultural-based learning at SMA Negeri 8 Kupang. The subject of this study were students, teachers, and vice principals. The data were obtained through observation, interview, and documentation. The study showed that multicultural-based learning was not included in the school curriculum, but the teacher was able to apply it in the teaching and learning process. Hence, the implementation of multicultural-based learning at school had been integrated with the subject materials in the curriculum. The goal is that the students can appreciate, and respect all the differences and make these differences in their citizenship statuses. Besides, it also become the hallmark of the nation and state life. The implementation of multicultural education was carried out through three programs, namely, a material-oriented program, a student-oriented program, and a social-oriented program.
THE PRINCIPAL'S ROLE IN DEVELOPING SCHOOL CULTURE AT SMA NEGERI 5 KUPANG
Authors: Sarifudin Ahmad Novia Andini
Published: April 2023

The objective of this research was to determine the role of the principal in developing school culture and to identify factors that support and inhibit the principal's role in developing school culture at SMA Negeri 5 Kupang. The qualitative method was implemented in this research, where the principal, teachers, and students from SMA Negeri 5 Kupang become subjects of research through a purposive sampling technique. Furthermore, data collection techniques include observation, interviews, and documentation. After that, the data analysis implements data collection, data reduction, data display, and conclusion. Based on research conducted at SMA Negeri 5 Kupang, there are two roles of the school (1) implementing regulations that can build school culture, such as discipline, tolerance, honesty, responsibility, overcoming problems, and giving firmness fairly to all school members, and (2) build communication in order to establish a good cooperative relationship with all school members. Besides, in the development of school culture, there are both supportive and inhibiting factors. School regulations and school community participation are important factors in developing school culture. While the lack of school community cohesion is an impediment to developing school culture.
PREVENTION OF IDENTITY THEFT: AN ANALYSIS
Authors: V.K. Vibhuti
Published: April 2023

Identity theft is the crime of acquiring other person's private or financial data for the purpose of assuming the name or identification of the victim and commit crimes. Such data can be used in the name of that victim to commit crimes in the name of the victim, to acquire credit or loans, products and services and even provide fake credentials to government authorities. The crime has advanced with the advancement of technology over the past few years in India. To prevent cybercrimes such as identity theft and other computerrelated/internet-based crimes, in the year of 2000, Indian Government enacted The Information Technology Act, 2000, amended in 2008. Identity theft is also governed by few provisions (Section 147A, Section 419, Section 463) of Indian Penal code, 1860. This research paper will analyze the implementation of the Act in India and other preventive measures taken by the Government of India relating to the matter of securing personal data and preventing the theft of identity. Key words: Identity, Identity theft, Data Technology, Cyber-crime, Phishing/vishing, Skimming, Hacking, Shoulder surfing, Dumpster diving, Mail theft, Pretexting.
DOPING IN SPORTS – ITS EVOLUTION AND ITS LEGALITY
Authors: Agarwal Akash
Published: April 2023

In the 20th and 21st century, doping in sports has become a much-debated and criticized topic. Despite being an age-old practice, it has been recently brought into regulations; both in the international and national context. This paper begins with an insight into the concept of doping and its complexities. With a brief background, the paper aims at discussing the international regulations surrounding doping in sports which were brought into place, followed by the antidoping laws adopted in India. The substantive as well as the procedural aspects of the issue are discussed with the help of two recent landmark judgments in the anti-doping laws jurisprudence. Further, the paper provides a comparative analysis on the turn of events on the legal validity of the International and National anti-doping laws, followed by the author’s reviews and criticisms on the anti-doping laws.
HUMAN RIGHTS AMID COVID-19 AND ITS EFFECT ON THE INDIAN ECONOMY
Authors: Banerjee Vaijayanti , Sharma Nimisha
Published: April 2023

Human Rights is a concept derived out of law initially to protect people with their property but eventually protecting all men and women. With the help of such rights, one can be ensured that under no circumstances a human being expected will be treated without dignity or unprotected from their natural rights. Any situation where a person’s dignity is questioned is a violation of their Human Rights. Any such violation is the beginning of the struggle for justice. Under no circumstances it is justified to deprive a person of their Human Rights in the ordinary course of events of life. The point where normalcy reaches a point beyond restraint is when it becomes a crisis. Any kind of crisis that harms the basic rights of a human becomes a human crisis which directly questions the state of affairs causing the harm. Through this paper, the authors shall examine what exactly is meant by Human Rights, Human Crisis and whether or not it is realistic to hold a single country responsible for such a crisis or are all to be blamed equally. The purpose of this paper is to bridge the gap of clarity and awareness regarding Human Crisis and the way Human Rights are dealt with during a time of crisis keeping in mind the economic conditions of the country and the policies to protect the interests of the citizens. Along with this, the political scheme that takes place parallel to such a crisis.
PROVA PENAL E A IMPLICAÇÃO DO FENÔMENO DAS FALSAS MEMÓRIAS
Authors: De Oliveira Braga França Davi Filipe , Figueiredo Pinto Rafael
Published: April 2023

A fase instrutória do processo penal é parte de extrema relevância para o devido processo legal, posto que nela o conjunto de provas apresenta toda a matéria útil à compreensão do fato delituoso em análise. A afluência entre a prova testemunhal e a memória traz riscos para o processo, em razão da situação psicológica do depoente influenciar ativamente no que vai ser por ele expresso, de modo que sua contribuição processual pode não se coadunar verdadeiramente com o fato, por ser sua memória passível de mudanças e influências. Assim, o escopo desse trabalho, de cunho bibliográfico, consiste na análise do fenômeno das falsas memórias, bem como sua influência na prova testemunhal utilizada no processo como prova. Para tanto, empregar-se-á na pesquisa o método hipotético-dedutivo.
INSERÇÃO DA ARBITRAGEM EM CONTRATOS ADMINISTRATIVOS DE PARCERIA PÚBLICO-PRIVADA E A ATRAÇÃO DE INVESTIMENTOS PÓS-PANDEMIA
Authors: Júnior Claudemir Fonseca Júnior
Published: April 2023

O presente artigo tem como objetivo verificar a utilização da Arbitragem pela Administração Pública para dirimir conflitos relativos a direitos patrimoniais disponíveis pós-pandemia. Questiona-se quais seriam os direitos disponíveis da Administração uma vez que, em regra, o interesse público é indisponível. Assim, será demonstrado que a Administração Pública é autorizada a utilizar-se da arbitragem, além de possuir direitos patrimoniais disponíveis. O método de pesquisa utilizado é o dedutivo e a pesquisa se desenvolve por meio de consultas aprofundadas a doutrinas nacionais e internacionais, leis e jurisprudência.
RELEVÂNCIA DA ANÁLISE PERICIAL DE COMPARAÇÃO BALÍSTICA COMO PROVA EM DELITOS PENAIS COM O USO DE ARMA DE FOGO
Authors: Oliveira Mendonça Kevin , De Oliveira Mendes Marco Antônio
Published: April 2023

O objetivo deste trabalho é analisar a relevância jurídica do instituto pericial de exame de comparação balística e sua influência na convicção do magistrado no julgamento de delitos penais com o uso de arma de fogo. O problema do trabalho nasce a partir do conhecimento de que a prova pericial, num todo, exerce uma função primordial no processo criminal; ao passo que, também, não pode ser utilizada em sua exclusividade para a prolação da sentença condenatória. Nesse sentido, através de uma pesquisa bibliográfica dedutiva, o trabalho estudou tópicos relacionados à balística criminal, sua metodologia e sua utilização nos órgãos jurisdicionais criminais. Ao fim, foi possível concluir que o exame pericial de comparação balística, embora utilizado exclusivamente nos casos de crimes com o uso de arma de fogo, é parte imprescindível do conjunto probatório processual, tendo seu uso devidamente fomentado por vários tribunais brasileiros nas sentenças condenatórias; e, inclusive, é fator necessário nos crimes de disparo de fogo por Policiais Militares em exercício de função.
Lễ hội Tháp Bà Pô Nagar trong đời sống văn hóa của cư dân tỉnh Khánh Hòa
Authors: Huỳnh Đức Thiện
Published: April 2023

Trên thế giới nước nào cũng có lễ hội, đây là một loại hình sinh hoạt đặc biệt mang tính văn hóa và tính cộng đồng cao, phản ánh tín ngưỡng và đời sống của người dân. Việt Nam là nước có nhiều lễ hội mang đậm dấu ấn lịch sử và truyền thống mấy ngàn năm xây dựng và bảo vệ đất nước. Đã có rất nhiều công trình nghiên cứu lễ hội dưới góc độ dân tộc học, xã hội học, tôn giáo học… nhưng tìm hiểu loại hình sinh hoạt này bằng cái nhìn văn hóa học thì vẫn còn rất hiếm. Bài viết “Lễ hội Tháp Bà Pô Nagar trong đời sống văn hóa ở tỉnh Khánh Hòa” sẽ được nghiên cứu bằng phương pháp văn hóa học, nhằm khám phá những đóng góp của lễ hội này cho đời sống văn hóa, đời sống tinh thần của người dân ở tỉnh Khánh Hòa. Cụ thể hơn, bài viết sẽ được triển khai theo cái nhìn loại hình văn hóa, hơi thiên về lý thuyết địa-văn hóa: đặt lễ hội được khảo sát vào trong hệ tọa độ văn hóa để tìm hiểu vai trò của nó đối với việc tổ chức xã hội, điều chỉnh xã hội, giao tiếp xã hội và giáo dục cộng đồng trong không gian địa lý cụ thể là tỉnh Khánh Hòa. Trên tinh thần hướng về cội nguồn, bài viết này muốn đóng góp một phần nhỏ vào công cuộc phát huy những giá trị truyền thống tốt đẹp và đạo lý của dân tộc cho việc phát triển đất nước hôm nay.
Nghiên cứu ý định sử dụng Ngân hàng điện tử của khách hàng tại Thành phố Hồ Chí Minh
Authors: Nguyễn Thị Ngọc Phương , Nguyễn Lê Hoàng Thuỵ Tố Quyên
Published: April 2023

Nghiên cứu tập trung phân tích ý định của khách hàng sử dụng dịch vụ Ngân hàng điện tử tại Thành phố Hồ Chí Minh. Dựa trên mô hình thống nhất chấp nhận và sử dụng công nghệ - UTAUT, nghiên cứu đã khảo sát 223 người tiêu dùng để tìm hiểu bảy nhân tố tác động đến ý định sử dụng dịch vụ Ngân hàng điện tử. Kết quả nghiên cứu đã cho thấy cả bảy nhân tố đều tác động đến ý định sử dụng Ngân hàng điện tử theo mức độ giảm dần: Nỗ lực mong đợi, Sự tin tưởng, Ảnh hưởng xã hội, Hiệu quả mong đợi, Giá trị chi phí, Động lực hưởng thụ. Trên cơ sở kết quả nghiên cứu, tác giả đưa ra hàm ý quản trị, đề xuất giải pháp tăng quy mô khách hàng có ý định sử dụng Ngân hàng điện tử, phù hợp với xu hướng thanh toán không dùng tiền mặt tại Việt Nam.
Mô tả phương pháp học tập và một số yếu tố liên quan đến kết quả học tập của sinh viên Trường Cao đẳng Y tế Bạc Liêu
Authors: Phạm Thị Nhã Trúc , Ngô Kiều LoI , Nguyễn Thị Lan Phương
Published: April 2023

Đặt vấn đề: Nghiên cứu nhằm đánh giá phương pháp học tập (PPHT) và một số yếu tố liên quan đến kết quả học tập của sinh viên Trường Cao đẳng Y tế Bạc Liêu (CĐYTBL) để có sự điều chỉnh hợp lý trong phương pháp dạy học, tiến đến thực hiện tốt công tác bảo đảm chất lượng của Nhà trường. Mục tiêu nghiên cứu: (1) Mô tả phương pháp học tập của sinh viên tại Trường Cao đẳng Y tế Bạc Liêu; (2) Xác định mối liên quan giữa phương pháp học với kết quả học tập của sinh viên tại Trường Cao đẳng Y tế Bạc Liêu. Đối tượng và phương pháp: Nghiên cứu sử dụng phương pháp mô tả cắt ngang, khảo sát 191 sinh viên chính quy đang học năm thứ hai tại Trường CĐYTBL với số liệu được thu thập bằng phương pháp phát vấn. Kết quả: Trong học tập, SV thường lựa chọn phương pháp nghe giảng (85.9%), ghi chép (83.2%) và tự học (81.7%), SV lựa chọn phương pháp đọc tài liệu chiếm thấp nhất (69.1%). Có sự khác biệt có ý nghĩa thống kê khi SV biết kết hợp > 3 PPHT thì kết quả học tập của SV sẽ đạt từ khá trở lên (p = 0.002), trong đó SV cần sử dụng thêm phương pháp ghi nhớ (p < 0.001) và đọc tài liệu (p = 0.013). Kết luận: Trong quá trình học tập SV cần biết cách phối hợp nhiều phương pháp để học, tăng cường kỹ năng đọc nhiều hơn. Nhà trường cần khuyến khích các giảng viên giao bài cho SV nghiên cứu để giúp SV tăng khả năng đọc tài liệu và cải thiện năng lực tự học.
Nghiên cứu các tiêu chí ảnh hưởng đến việc lựa chọn vị trí đặt bãi đỗ xe ô tô bán tự động, quy mô vừa và nhỏ cho khu vực đô thị Quận 2, Thành phố Hồ Chí Minh
Authors: Trần Thanh Hà , Nguyễn Hồng Minh Anh , Lê Hoàng Ý
Published: April 2023

Với các ưu điểm như nhỏ, gọn, chiếm ít quỹ đất, thi công nhanh chóng, mô hình đỗ xe ô tô bán tự động đã được ứng dụng tại nhiều đô thị trên thế giới. Với các đặc điểm kỹ thuật phù hợp với nhu cầu và đặc trưng của Thành phố Hồ Chí Minh, thì giải pháp mô hình đỗ xe ô tô có thể là chìa khóa để giải quyết nhu cầu đậu xe cho khu vực đô thị. Tuy nhiên việc lựa chọn vị trí tối ưu để đặt mô hình đỗ xe không hề dễ dàng trên phương diện phát triển đô thị bền vững và hài hòa. Do đó, nhóm nghiên cứu đã tiến hành đề xuất mô hình ra quyết định đa tiêu chí (Multicriteria Decision Making Model-MCDM) nhằm phân tích lựa chọn các tiêu chí ảnh hưởng đến vị trí chọn đặt bãi đỗ xe ô tô bán tự động. Đóng góp của nghiên cứu này là bộ tiêu chí gồm 4 tiêu chí mẹ và 18 tiêu chí con, được chọn lựa ra nhằm giúp các doanh nghiệp tư nhân và các cơ quan quản lý Nhà nước có thể tham khảo để lựa chọn vị trí tối ưu cho bãi đỗ xe nhằm giúp tăng hiệu quả sử dụng và hướng tới phát triển giao thông đô thị bền vững.
Management solutions and improvement on wasted water quality
Authors: Nguyen Quoc Khanh , Dang Quang Vang
Published: April 2023

Social development, the amount of domestic and industrial wastewater also increases exponentially. However, the centralized treatment systems are not enough to deal with (As of the end of 2018, the percentageg of domestic wastewater and industrial wastewater collected and treated in Vietnam are low at 13%, 88% and 15.8% respectively) impairing the quality and amount of surface water sources, affects the quality of groundwater resources, ecosystems, and threatens water security. This has been affecting the daily life and production of the people. To mitigate this situation, wastewater reuse is seen as an effective and appropriate solution for the city. The above situation requires the State to have regulations and circulars guiding the reuse of wastewater, improve regulations and standards to suit the current situation, gradually reduce pollution and protect the water environment.
INVESTIGATION OF THE SEASONALITY OF OCCUPATIONAL ACCIDENTS IN MINE OPERATIONS
Authors: TURAN Sevda , KAHRAMAN Muhammet Mustafa
Published: April 2023

Mine operations might be viewed as relatively risky in terms of worker safety when compared to other industries. Every year, there are a lot of occupational accidents and near-misses at mining sites. Most of the time, data from these circumstances are recorded, but they are typically not properly utilized. Information gathered from occurrences helps researchers understand how various conditions affect accidents and their frequency. The information obtained from such investigations may provide practical advice on how to prevent happening again. For instance, there are many studies in the literature that analyze mining accidents according to their countries, yearly frequency, work areas, and types of work; however, there isn't a single study that looks at the relationship between meteorological conditions and the seasonality of the accidents. The correlations between seasonal and regional variables, such as temperature, humidity, and pressure, and occupational accidents that occurred in mines with various climatic features, chosen from two different nations, were examined in this study. The findings indicate that there is a strong relationship between the frequency of accidents and the seasons, however this relationship would be weaker if incidents were looked into on a monthly basis. In conclusion, this article demonstrates that temperature and humidity in mining operations during severe weather conditions have a significant impact on occupational accidents.
EFFECTS OF GRAVITY’S RAINBOW ON A RELATIVISTIC SPIN-1 OSCILLATOR
Authors: GÜRTAŞ DOĞAN Semra
Published: April 2023

We consider a relativistic spin-1 particle with non-minimal coupling in the context of gravity’s rainbow in the three dimensional background spacetime spanned by static cosmic string. In this context, we acquire an exact solution of the associated spin-1 equation in the modified three dimensional static cosmic string-spanned background spacetime. This relativistic wave equation includes a reducible spinor and this allows us to acquire a non-perturbative expression including the modification functions in the energy domain. In the low energy limit, our results agree well with current literature and provide a basis to discuss the fundamental features of the relativistic spin-1 oscillator. Afterwards, we try to discuss the effects of gravity rainbow functions on the considered spin-1 oscillator in three different scenarios for the modification functions.
INVESTIGATION OF THE STRAIN RATE SENSITIVITY OF Mg-6Sn AND Mg-6Sn-3Y ALLOYS
Authors: YARKADAŞ Güven
Published: April 2023

This study reports the influence of the addition of Yttrium (wt.3%) on strain-rate sensitivity of Mg-6Sn alloy. The Mg-6Sn and Mg-6Sn-3Y alloys were made by using high pressure die-cast. The microstructural and X-ray diffraction results exhibited that the Sn3Y5 and MgSnY intermetallic phases were formed with addition of Y to the Mg-6Sn alloy. Furthermore, the grain structure of the Mg-6Sn alloy was changed from dendritic to globular with addition of Y. The strain-rate sensitivity value of the Mg-6Sn-3Y alloy is found higher than that of the Mg-6Sn alloy for all strain value. This result was attributed to the formation of new intermetallics (Sn3Y5 and MgSnY) and microstructure morphology (from dendritic structure to globular).
DESIGN AND APPLICATION OF AC/DC SWITCHING POWER SUPPLY WITH HALF BRIDGE DC/DC CONVERTER TOPOLOGY FOR BATTERY SYSTEMS of ELECTRICAL VEHICLE
Authors: AKGÜL Celaletdin , ÇETİNCEVİZ Yücel , ŞEHİRLİ Erdal
Published: April 2023

This study presents design, analysis and application details of electrical vehicle battery charge device based on half bridge DC-DC converter. Half bridge DC-DC converter in the paper has 620 W power, 25 kHz switching frequency and input DC voltage is obtained by uncontrolled bridge rectifier. In addition, information about the battery that is charged, and battery pack are given. Besides, a protection structure of battery is added by measuring both current and voltage of battery. Firstly, equations required for half bridge DC-DC converter is derived and simulation of battery charge circuit is realized by using PSIM and MATLAB/Simulink. Then, the results of the experimental study and the simulation results are given comparatively. The experimental results prove the accuracy of the simulation studies.
FACILE AND CONTROLLED SYNTHESIS OF 2D ORGANOMETAL HALIDE PEROVSKITE PURE BA2MAPb2I7 AND HETEROSTRUCTURED BA2PbI4/BA2MAPb2I7 SINGLE CRYSTALS
Authors: YILMAZ Alp , YELTİK Aydan
Published: April 2023

Two dimensional (2D) organometal halide perovskites (OHPs) have attracted intensive interest for their diverse optoelectronic applications. However, a practical and controllable solution-based way particularly for the synthesis of pure BA2MAPb2I7 and heterostructured BA2PbI4/BA2MAPb2I7 single crystals, which are of great importance for high performance photodetectors, is still lacking. In this study, we report the efficient synthesis route of large-area high-quality BA2MAPb2I7 and BA2PbI4/BA2MAPb2I7 single crystals. We show that the combined method of solution temperature lowering and limiting reagent approaches yields rapid and controllable synthesis. In addition, the correct determination of the BAI:MAI:PbI2 molarity ratios in the synthesis process was revealed to be highly significant. These results provide fundamental insight and useful guideline for obtaining the presented 2D OHPs with regard to high practicality and controllability.