bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection and Prevalence of Inducible Clindamycin Resistance in Clinical Isolates of Staphylococcus aureus: Experience from Tertiary Care Hospital in Jaipur
Authors: Shrigaur Aishwarya , Mamoria Ved Prakash , Rajni Ekadashi , Sharma Richa
Published: May 2022

Background: Staphylococcus aureus is a frequent cause of bacterial infections in both developed and developing countries. Emerging resistance to methicillin in this organism has left us with very few therapeutic alternatives to treat the infections caused by them. Objective: We aimed to determine the prevalence of inducible clindamycin resistance in clinical isolates of S. aureus and antimicrobial susceptibility pattern of S. aureus isolates due to the increasing prevalence of resistance to most antimicrobial agents in staphylococci signifies the need for new effective agents to treat staphylococcal infections. Methods: The study was carried out in the Department of Microbiology at Mahatma Gandhi Hospital, Sitapura, Jaipur, Rajasthan. All S. aureus isolates (non-repetitive) from different clinical samples received in clinical microbiology laboratory from in and outpatients in Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, were included in the study. Results: Out of 157 erythromycin-resistant S. aureus, 74 (47.133%) show MS phenotype, 48 (30.57%) show inducible clindamycin resistance, and 35 (22.29%) show constitutive resistance. All 48 S. aureus isolates which showed inducible clindamycin resistances (D-test positive) were further subjected to antimicrobial susceptibility testing.In the present study, 100% sensitivity was observed by vancomycin, linezolid and tigecycline, followed by tetracycline, 89.58% and gentamicin, 83.33% while 100% resistivity were observed by levofloxacin. Conclusion: We can conclude that there is high percentage of inducible clindamycin resistance among Staphylococcus isolates. If D-test would not have been performed, many inducible clindamycin-resistant S. aureus could have been easily misidentified as clindamycin susceptible, leading to therapeutic failure. Thus, simple and reliable D-test can be incorporated into routine in clinical microbiology laboratory.
Marital and Sexual Satisfaction, Depression, Anxiety, and Stress among Wives of Patients with Chronic Illnesses
Authors: Umrigar Daanesh M. , Mhaske Rajendra S. , Bhargava Swarnima , Thorat Shivanand R.
Published: May 2022

Objectives: The objectives of the study were to explore the psychological health, as well as the levels of marital and sexual satisfaction, of wives of patients with a chronic illness. Methods: The sample consisted of 34 women, whose husbands were diagnosed and undergoing treatment for a chronic illness (coronary heart disease; diabetes; or cancer). Results: Correlational, comparative, and predictive analyses were conducted on the data. Clinically significant marital and sexual dissatisfactions were found. Wives reported moderate levels of depression and anxiety, but severe levels of stress. Depression and sexual satisfaction were found to be significant predictors of marital satisfaction. Marital dissatisfaction scores were significantly lower for wives who were employed as compared to unemployed wives. Discussion: Wives are impacted by the illness status of their spouse. The additional stress of caregiving, along with societally ascribed roles and responsibilities on women, creates a more difficult, stressful environment, which affects the relationship satisfaction as well as psychological health and well-being.
Impact of Covid-19 Pandemic on the Accredited Social Health Activists: An Exploratory Study in Rangareddy District of Telangana, India
Authors: Kirtania Mousmi , Prasad M. Surya Durga
Published: May 2022

The whole world is immensely dealing with the COVID-19 which was originated from the Wuhan city in the end of 2019. All the countries have been in a devastating state by the sudden outbreak which led to many deaths from the deadly infection. Many low- and middle-income countries are being suffering due to the poor healthcare infrastructure and a smaller number of healthcare workers. India is one of them. Due to the insufficient number of healthcare workers, the workload on the existing numbers has increased to a double-fold, especially on the grass-root workers. Accredited Social Health Activist (ASHA), an initiative of the National Rural Health Mission in India is involved in the implementation of the primary health care facility at the grassroot level. The effective implementation of the health care policy depends on the performance of the ASHA workers. The present study aims to identify the challenges and barriers faced by the ASHA workers while delivering their services during the pandemic times and provide policy suggestions for strengthening of the grass-root level health care workers for facing any kind of future health emergencies.
A Case of Gilbert Syndrome and Uncontrolled Diabetes Mellitus with Elevated HbA1C Improved with Individualized Homeopathic Medicine
Authors: Kannan C. , Jane Preena , Venkadakrishnan P.
Published: May 2022

Diabetes mellitus is one of the most common metabolic disorders in the present era from altered lifestyle. Glycosylated hemoglobin (HbA1C) is the most reliable blood parameter for diagnosis and prognosis of diabetes mellitus. Gilbert syndrome in diabetic patients lowers the prevalence of microvascular complications of diabetes mellitus. Even though Gilbert syndrome is a fortunate factor in this patient, progressive weight loss is the raising concern. From proteolysis and diuresis, kidneys can get damaged in course of time. Uncontrolled HbA1C again can increase the risk of complications of diabetes mellitus. In this case, HbA1C and weight loss with diabetes mellitus improved with an individualized homeopathic approach. Natrum Muriaticum was selected on a constitutional basis, and it was administered on an LM scale which helped the patient in bringing down blood parameters and managing weight loss of Diabetes.
Effect of Lowering the pH of Sodium Hypochlorite on Control of Pseudomonas aeruginosa in Maintenance of Pharmaceutical Water System
Authors: Mannepalli Koteswara Rao , Deshpande Bhagyashree , Mundeja Prashant
Published: May 2022

Drinking water or potable water is a common source for generation of purified water or demineralized water which is used for processing of medicinal products such as tablets, capsules, syrups, and nasal sprays. Before allowing for purification, it is manufacturer’s responsibility to ensure the microbial load control in the source water to get good quality product water and to avoid biofilm formation in waterlines. The current research involves the study of an effectiveness of sodium hypochlorite (NaOCl) at various concentrations of water pH on microbial control by following pour plate technique. The aim of this study was to examine the effect of lowering the pH on the recovery of Pseudomonas aeruginosa. Three groups were tested by challenging known population of P. aeruginosa by varying the pH of 5.0, 7.0 and 9.0. No significant difference was observed at pH 5.0 and 7.0 and the recovery increased when the pH increased at 9.0. Effective microbial control was obtained at neutral pH. The increase of pH resulted decrease of effectiveness of NaOCl.
Cystic Artery: Incidental Variation of Origin
Authors: Gupta Shalini , Gupta Ashish Kumar , Marwaha Rita , Bhalerao Nisha
Published: May 2022

On the basis of origin, variation of cystic artery is commonly found. Commonly, cystic artery originates from the right hepatic artery and rare condition from celiac trunk. The position of the cystic artery possesses extraordinary importance for the surgeon during cholecystectomy, because the cystic artery is the primary structure to be clipped or tie up during cholecystectomy. In this study, during cadaveric dissection incidentally found rarest condition that cystic artery originating from celiac trunk. These anatomical findings are much important for surgical and radiological aspect and may be helpful for surgeons during the performance of surgeries involving hepatic and biliary apparatus.
Evaluation of Phytochemical Profile and In Vitro Antioxidant, Anti-bacterial and Anti-inflammatory activity of Piper schmidtii Hook. fil. A Wild Edible Fruit
Authors: Pradheeba M. , Pugalenthi M. , Deepa M. A. , Kumar S. Vishnu , Vasukipridharshini G.
Published: May 2022

Aim: The present study aims at screening the phytochemical components and evaluates the antioxidant, anti-bacterial, and anti-inflammatory activity of fruit of Piper schmidtii, an endemic plant species from The Nilgiris, Tamil Nadu. Materials and Method: The different polar solvents such as petroleum ether, chloroform, ethyl acetate, methanol, and water were used and extraction was carried out using the soxhlet apparatus. The extracts were screened for qualitative and quantitative phytochemical analysis. The extracts of P. schmidtii were also subjected to in vitro-antioxidant activity by DPPH assay, Phosphomolybdenum assay, Ferric reducing antioxidant power (FRAP), superoxide radical scavenging activity, and reducing power assay. Results: Among all the extracts, methanol extract exhibited the maximum amount of phenolics (731.91 mg GAE/g extract), tannin (726.6 milligrams of Gallic acid equivalent/g extract), and ethyl acetate extract depicted the maximum quantity of flavonoids (698.17 mg QE/g extract). Methanol extract of P. schmidtii revealed the higher antioxidant activity in all the assays with IC50 values of 15.19 μg/ml (DPPH), 135.67 mg AAE/g (Phosphomolybdenum assay), 380.98 mM Fe/mg (FRAP), 60.94% (Superoxide) and higher reducing power was depicted in the ethyl acetate extract, respectively. Further anti-bacterial activity revealed that the methanol extract shows highest inhibitory activity against the tested bacterial pathogens. The methanol extract showed high degree of inhibition (71.24%) in anti-inflammatory assay. Conclusion: Thus, the result support that P. schmidtii is a potential source of natural antioxidant that can inhibit bacterial growth and subside inflammation.
Comparison of Hematological Profile of Athletes in Various Phases of Menstrual Cycle
Authors: Yadav Tanu Shree , Pandey Gayatri , Kumar Gopal
Published: May 2022

The purpose of the study was to compare the hematological parameters during the different phases of the menstrual cycle viz Menstrual, Follicular, Ovulation, and Luteal Phase. Thirty athletes were selected as subjects for the study who were involved in speed-endurance dominated sports. Blood samples were taken in each phase and analyzed for the following hematological variables - Red blood cells (RBCs), White blood cells (WBCs), Hemoglobin (Hb), and platelets. The results of the study showed variations in hematological parameters throughout the menstrual cycle. RBC and Hb levels significantly increased during the follicular phase (FP) but remain unchanged in the ovulation and luteal phase. WBC levels also increased during the FP, were almost similar in ovulation phase, and slightly decreased in the luteal phase. Platelet count followed a similar pattern as WBC. Platelet count increased in the FP but decreased in the luteal phase. Menstrual phase is characterized by hemorrhage which results in blood loss and decreased levels of hematological parameters. FP is seen as compensatory phase in which the hematological variables significantly increase. WBC and Platelet count decrease in the luteal phase in attributed to the decrease in the estrogen levels. The study concluded that variations in hematological parameters is observed during the different phases of the menstrual cycle.
Clinical and laboratory specific parameters of COVID-19 in patients with TB/HIV co-infection
Authors: Alzhanov R. S. , Pyatibratova A. V. , Krasnov D. V. , Kapustin D. V. , Anufriev S. V.
Published: May 2022

The objective: to study clinical and laboratory specific parameters of the COVID-19 course in patients with TB/HIV co-infection, to analyze changes in the lungs caused by COVID-19 in patients with pulmonary tuberculosis and concurrent HIV infection.

Subjects and Methods. 68 HIV-infected patients aged 18-66 years old were included in the study, they all were admitted to the Novosibirsk State Regional Clinical Tuberculosis Hospital, Novosibirsk, with confirmed COVID-19 from May 2020 to May 2021. Clinical manifestations, CD4 count and HIV RNA level, and the presence of secondary infections were assessed.

Results. In patients with severe and profound immunodeficiency, coronavirus infection was more often mild to moderate, and in immunocompetent patients – moderate to severe. However, patients with profound immunodeficiency were at greater risk of an adverse outcome due to lymphohematogenic progression of tuberculosis and concurrent opportunistic infections.

Conclusion. When diagnosing and treating COVID-19 in patients with comorbid HIV infection and tuberculosis, it is important to consider the form of tuberculosis and CD4+ count.
Models of сlinical situations – a new methodological approach to analysis of patient populations in TB facilities
Authors: Pyanzova T. V. , Dzhangildin Yu. T. , Vasilyeva I. А.
Published: May 2022

The objective: to develop methodological approaches for assessing patient population in a TB unit based on models of patients who died in a TB hospital.

Subjects and Methods. A retrospective study included 413 patients who died in a TB hospital during periods of varying HIV infection prevalence. As a methodological approach to assessing the structure of this group of patients, 4 models of clinical situations have been proposed. The models considered severity and presence of tuberculosis infection, HIV infection, lesions of the central nervous system and concomitant non-communicable diseases. As an example of proposed clinical models, a comparison was made of deceased patients in a TB hospital in two periods – 2007 and 2017, which differed mainly in the prevalence of HIV infection among TB patients.
Risk factors of dyspeptic syndrome in patients staying in a tuberculosis in-patient unit and the state of intestinal microflora of patients before the start of anti-tuberculosis therapy
Authors: Kholodov А. А. , Zakharova Yu. V. , Otdushkina L. Yu. , Pyanzova T. V.
Published: May 2022

The article describes risk factors for the development of intestinal indigestion syndrome (IIS) in 109 patients with tuberculosis while they were receiving anti-tuberculosis chemotherapy (ATCT) and the results of assessment of the intestinal microbial population in 30 patients with tuberculosis before chemotherapy start. The following factors made significant contribution to development of intestinal indigestion syndrome: HIV infection, the number of doses of anti-tuberculosis drugs taken, and chronic gastrointestinal diseases. Even before the start of chemotherapy, the patients had disorders of the intestinal microflora, which were characterized by a decrease in the quantity of obligate bacteria, and higher frequency and number of facultative and transient bacteria.
Investigating the Impact of Rater Training on Rater Errors in the Process of Assessing Writing Skill
Authors: ŞATA Mehmet , KARAKAYA İsmail
Published: May 2022

In the process of measuring and assessing high-level cognitive skills, interference of rater errors in measurements brings about a constant concern and low objectivity. The main purpose of this study was to investigate the impact of rater training on rater errors in the process of assessing individual performance. The study was conducted with a pretest-posttest control group quasi-experimental design. In this research, 45 raters were employed, 23 from the control group and 22 from the experimental group. As data collection tools, a writing task that was developed by IELTS and an analytical rubric that was developed to assess academic writing skills were used. As part of the experimental procedure, rater training was provided and this training was implemented by combining rater error training and frame of reference training. When the findings of the study were examined, it was found that the control and experimental groups were similar to each other before the experiment, however, after the experimental process, the study group made more valid and reliable measurements. As a result, it was investigated that the rater training given had an impact on rater errors such as rater severity, rater leniency, central tendency, and Halo effect. Based on the obtained findings, some suggestions were offered for researchers and future studies.
Pendekatan Paulus dalam Penyelesaian Konflik Perbudakan: Analisis Sosio-Historis terhadap Surat Paulus kepada Filemon
Authors: Wenno Vincent Kalvin
Published: May 2022

Abstract There are many texts and interpretations of slavery and its problems in the Greco-Roman world. However, few have attempted to unravel the approaches and strategies used to resolve the conflict by Paul with people/communities who have accepted the gospel. This study focuses on Paul’s role as a mediator to the slavery conflict between Philemonand Onesimus in his letter to Philemon. This study aims to analyze: First, the reasons for Paul being concerned on the issue of slavery in his letter to Philemon. Second, Paul’s approach in resolving the slavery conflict. Third, the relevance of Paul’s approach in resolving the slavery conflict in modern life. To reach these objectives, this study uses a socio-historical interpretation method, which emphasizes the reciprocal relationshipbetween humans with all their dynamics and interactions, which also influences the meaning of the biblical text. The data collected in the form of literature studies/scientific literature related to the title of this study, were processed and presented in the form of a description.

Abstrak Ada banyak teks dan penafsiran tentang isu perbudakan dan masalahnya dalam konteks masyarakat Yunani-Romawi pada masa Rasul Paulus. Namun demikian, kajian mengenai pendekatan dan strategi Paulus dalam penyelesaian konflik pada orang/komunitas yang telah menerima Injil, masih jarang dilakukan. Studi ini mempertanyakan peranan dan pendekatan yang dipakai Paulus dalam konflik perbudakan dan relevansinya dalam konteks masa kini. Dengan menggunakan kritik sosio-historis, studi ini bertujuan untuk menganalisis: Pertama, Alasan isu perbudakan menjadi perhatian Paulus dalam suratnya kepada Filemon. Kedua, Pendekatan Paulus dalam penyelesaian konflik perbudakan. Ketiga, Relevansi pendekatan Paulus dalam penyelesaian konflik perbudakan dalam kehidupan modern. Untuk mencapai tujuan tersebut, studi ini menggunakan metode penafsiran sosiohistoris, yang menekankan pada hubungan timbal balik antar manusia dengan segala dinamika dan interaksinya, yang turut memengaruhi pemaknaan teks Alkitab. Data yang dikumpulkan berupa kajian-kajian pustaka/literatur ilmiah yang berhubungan dengan judul studi ini, kemudian akan diolah dan disajikan dalam bentuk deskripsi.
Brief Review of the Genus Diospyros Montana Roxb: Phytopharmacological Properties
Authors: Venugopal Sujatha , Alagesan Venkatesan
Published: May 2022

Diospyros montana Roxb. (F: Ebenaceae) commonly known as Ebony is a species of flowering tree native to India and other countries. These plant part as a whole in used in treatment of several diseases in particular, leaves and bark are used in folk medicine for the treatment of fish poison, anti-inflammatory, anti cancer etc. This present investigation reviews the bioactivity of flavonoids, phenols, carbohydrates, amino acids, protein, saponins, alkaloids, tannins, sterols, anthocyanin and anthraquinones, fixed oils and fats, and their presence in various parts of Diospyros montana. The significant constituent such as Diospyros, Isodiospyrin, Oleanolic acid, quercetin, β-amyrin and kaempferol have been isolated from various parts of the plant is discussed with a detailed description. The narrower approach indicates that Diospyros montana possess various pharmacological activities like antiviral, anticancer, antitumor, antimalarial, anthelmintic, prostaglandin synthesis inhibitory, anti-inflammatory, hypolipidemic, and antileukemic agent and several other important medicinal properties. This review focus on comprehensive and categorized information on the botany, traditional uses, phytochemistry and pharmacological aspects of Diospyros montana which provide valuable information to researchers for continuing further scientific work on this plant.
Criminalistic support of activities of the Bureau of Economic Security of Ukraine: problems and directions for improvement
Authors: Shevchuk V. M.
Published: May 2022

The article is devoted to the study of current problems of criminalistic support of the Bureau of Economic Security of Ukraine (hereinafter BES of Ukraine). Modern scientific approaches and perspective directions of improvement of activity of the newly created body which is assigned tasks on counteraction to the offenses encroaching on functioning of economy of the state are analyzed. The most perspective directions of improvement of activity of this body are allocated, potential risks of realization of new approaches in activity of bureau are defined. Emphasis is placed on the need to take into account a comprehensive approach to solving problems in the field of combating criminal threats, which can ensure the success and effectiveness of this newly established body in the field of economic security of Ukraine.It`s substantiated that the essence of forensic support of the BES of Ukraine should be considered as: 1) activities to create conditions for the effective application of criminalistic knowledge and tools (technical-, tactical- and methodological-criminalistic) and collection and research of evidence on the facts of criminal offenses in economic and financial spheres, solving criminal and criminal proceedings means; 2) a specific type of criminalistic activity carried out by certain entities in order to optimize, improve the efficiency and quality of investigation and prevent this category of criminal offenses. This approach determines the need to develop the concept of a separate theory of criminalistic support of the BES of Ukraine as a priority area of research in modern criminalistic doctrine. A comprehensive study of this problem involves taking into account three areas - technical -, tactical - criminalistic and the direction of ensuring the formation and improvement of criminalistic methodics of investigating criminal offenses of economic orientation.It`s noted that the introduction of fundamentally innovative approaches to combating criminal threats in the field of economic security in Ukraine in turn creates the basis for possible potential in the activities of this body and the implementation of such new approaches in practice. Therefore, the mechanism for introducing a new such body and implementing the provisions of this Law should be sufficiently balanced, well thought out and clearly legally defined. The scientific approaches and offers on the decision of researched problems are formulated, possibilities of application of criminalistic knowledge in practical activity of this body are analyzed, perspective directions of the further scientific researches of this problems are outlined.
On the problem of criminal law protection of state symbols: Ukrainian and foreign experience
Authors: Samoshchenko I. , Zhytynskyi O.
Published: May 2022

The article reveals the problem of Ukrainian and foreign state symbols criminal law protection considering domestic and world practice. The relevant norms of criminal laws of the Russian Empire, USSR and Poland, which were in force in the Ukrainian lands in the XIX-XX centuries, have been examined. An analysis of domestic judicial practice in criminal cases related to the abuse of state symbols has been done. It has been illustrated that Ukrainian law enforcement agencies do not always correctly determine the nature of this crime. That is due to the lack of constitutional laws enshrining the system of state symbols of Ukraine, as well as gaps in legal regulation, in particular in the aspect of criminal protection of the European Union flag as membership in this organization is a strategic foreign policy priority of Ukraine. Inter alia, the erroneous legal treatment of individuals’ actions during the protest which took place near the President’s Office on March 20, 2021 as an insult to the State Emblem has been emphasized. The authors also considered solutions of the problem within the framework of a particular legal system – in criminal law of the United States, Germany, France, Spain, Iceland, the United Arab Emirates, Uzbekistan, Japan and other countries. The scientific novelty of this investigation, among other things, is in the examination of both retrospective and prospects of legal responsibility for disrespect of the State language, which is necessary to establish according to the Constitutional Court’s decision on the validity of the Law of Ukraine “On ensuring the functioning of the Ukrainian language as the state language”. However, the authors are inclined to think that this issue should be regulated by administrative law, given the experience of some post-Soviet states. Proposals for amendments to the Criminal Code of Ukraine have been made.
Validitas Flash Card Spermatophyta Sebagai Penunjang Pembelajaran Botani Tumbuhan Tinggi
Authors: Ita Ita , Pertiwi Agustina Ambar , Himmah Nurul , Hafifah Gusti
Published: May 2022

Botani Tumbuhan Tinggi merupakan mata kuliah yang mengkaji tentang tumbuhan berbiji. Banyaknya konsep yang perlu dipelajari menjadikan mata kuliah ini sering dianggap sebagai mata kuliah hafalan. Oleh karena itu diperlukan media penunjang dalam prosesnya pembelajarannya. Flash card adalah salah satu alternatif media pembelajaran yang dapat dikembangkan dalam rangka menghadirkan berbagai spesies tumbuhan di alam ke dalam sebuah kartu yang memudahkan mahasiswa prinsip pengelompokkan berbagai spesies tanpa harus menghafal. Penelitian ini bertujuan untuk mengetahui validitas flash card spermatophyta sebagai penunjang pembelajaran Botani Tumbuhan Tinggi. Jenis penelitian ini adalah Research and Development, uji validitas flash card menggunakan Evaluasi Formatif Tessmer yang dibatasi pada tahap uji pakar. Hasil uji validasi ahli media diperoleh skor rata-rata sebesar 79,5% dan hasil validasi ahli materi diperoleh skor rata-rata sebesar 83,6%. Berdasarkan hasil skor rata-rata dapat disimpulkan bahwa flash card yang dikembangkan valid dan dapat digunakan sebagai media untuk menunjang pembelajaran Botani Tumbuhan Tinggi.
Validitas Media Pembelajaran Berbasis Web pada Materi Sistem Pernapasan Manusia Kelas VIII di SMP
Authors: Mufidah Lailatul , Habibi Mohammad Wildan
Published: May 2022

Ilmu Pengetahuan Alam adalah sebuah ilmu yang menghubungkan antara alam bahkan manusia yang sangat luas serta terbentuk secara ilmiah. Seiring dengan perkembangan ilmu pengetahun dan teknologi di era globalisasi proses belajar mengajar menjadi modern. Perlunya menggunakan media web yang praktis dan efektif mendukung keberhasian pembelajaran IPA dan menambah pengetahuan teknologi yang ada di sekolah. Tujuan dari penelitian ini yaitu untuk mengetahui validitas dan respon siswa mengenai media pembelajaran berbasis web. penelitian ini menggunakan model tahapan ADDIE yaitu analysis, design, development, implementation, dan evaluation. Akan tetapi peneliti hanya sampai tahapan implementasi karena adanya keterbatasan waktu. Subjek penelitian ini terdiri dari dua dosen, dua guru, 10 siswa  dalam uji skala kecil, serta 30 siswa untuk uji skala besar. Hasil penelitian menunjukkan bahwa pengembangan media pembelajaran web pada materi sistem pernapasan manusia dikategorikan valid dengan persentase ahli materi 95%, ahli media 88%, guru TIK 84% serta  guru IPA 92% sehingga persentase keseluruhan yaitu 90%  layak digunakan sebagai alat bantu siswa mengenai materi sistem pernapasan manusia. Berdasarkan penelitian yang telah diterapkan oleh peneliti bahwa media ini harus lebih dimodifikasi dari segi konten agar kedepannya semakin berkembang serta pendidik harus lebih memahami dan mempelajari teknologi yang lebih lanjut.
The mechanical behavior of a long-span steel-box girder during the hoisting process
Authors: Duan Min , Liao Nengwu , Zhang Liangliang , Hu Xiaoming
Published: May 2022

A steel-concrete hybrid continuous rigid frame bridge was used for the Jiahua bridge. The span layout is 138 m + 252 m + 110 m. The steel box-girder, 90 m in length, was arranged in the middle of the mid-span. During the construction process of this bridge, the adopted method for the large steel box girder section is the whole lifting process, which is not common for this type of bridge. This study investigates the mechanical behavior of the steel-concrete joint through finite element analysis, aiming to understand the stress distributions of the long-span steel box girder in several integral hoisting conditions, which can be a reference to the construction of similar steel box bridges. The results show that the bottom plate stress of the mid-span section has a linear relationship with the lifting acceleration; the top plate stress of the mid-span section has a cubic nonlinear relationship with the lifting acceleration.
REKLAMCILIĞIN YENİ YÜZÜ; ETKİLEŞİMLİ AÇIKHAVA REKLAMLARI
Authors: Başer Akyürek Asena , Keş Yusuf
Published: May 2022

Toplumun güncel alışkanlıklarına cevap verebilen yeni medya araçları ile rekabetini olduğu hali ile sürdüremeyeceğini anlayan geleneksel medya, yeni medya ile ortak çalışma yolunu seçmek zorunda kalmıştır. Yeni medyanın hedef kitleye sağladığı zaman, mekan sınırsızlığıyla, müdahaleye açık olma haliyle ortaya çıkan etkileşime teşvik etme yeteneğini, geleneksel medya kendisine de entegre edebilmelidir. Etkileşimde bulunmayı seven, mesaj karşısında pasif kalmayı ret eden, reklamı yönlendirmeyi isteyen hedef kitleden burada kullanıcı olarak söz etmek mümkündür. Bu çalışmada; gününün önemli bir kısmını evinin dışında geçiren yeni insan tipi için en uygun olabilecek “açıkhava reklam araçları” ele alınacaktır. Açıkhava reklam araçlarının bünyelerinde barındırdıkları avantajlara etkileşim unsurunun da eklenerek yeni insan tipine uyarlanması ve bu geleneksel medya aracının melezleşmesi ile hayatta kalması sağlanarak, reklam dünyasında önemli olan bir materyalin yok olup gitmesinin önüne geçileceği gerçeği üzerinde durulmuştur.
Predictors of access to safe drinking water: policy implications
Authors: Shadabi Leila , Ward Frank A.
Published: May 2022

Nearly one-quarter of the world's population lacks effective access to safe drinking water (SDW). The discovery and implementation of affordable and workable measures to supply safe affordable drinking water internationally remains elusive. Few works have examined a range of economic, institutional, and governance factors influencing that access. To address these gaps in the literature, the current study investigates the role of selected economic, demographic, and hydrologic characteristics as well as institutional and governance indicators, all of which could contribute to explaining access to SDW internationally. It estimates regression models based on data from 74 countries for the period 2012–2017. Results contribute to our understanding of factors that are significant at influencing access to SDW. Results show that demographic, economic, size of the public sector, governance, and educational factors all play important roles. Surprisingly, the avoidance of high levels of corruption and the protection of high levels of civil liberties reveal weaker-than-expected effects. Results carry important implications for informing choices facing communities who seek economically affordable measures to provide access to safe affordable drinking water.
Biophilic Philosophy of Josef Šmajs
Authors: Lípa Jan , Rozenský Ladislav , Ondrušák Petr , Vrba Zdeněk , Dolista Josef
Published: May 2022

In the field of ecoethics, in addition to names such as Kohák, Vavroušek, Keller, and Librová, we are increasingly encountering the name of a Czech philosopher, Professor Josef Šmajs. In his works, Professor Šmajs presents an entirely new, original, and comprehensive view of human life on Earth and its ethics. His concept combines the humanities and natural sciences into a single organic whole. Šmajs declares: “We are the products of a magnificent natural evolution, but we are proud only of our cultural creativity. We think – and we teach it in schools – that we complete humanity with human culture and humanize it. However, the truth is different. Nature is original, self-sufficient, and perfect; we cannot complete or humanize it.” He further claims that “If we want to survive on Earth, we must wisely give way to nature wisely in time. The epoch of the symbiosis of culture and nature is still ahead of us.” His philosophy, which can be called biophilic, interprets the current form of the ecological crisis and its causes and provides a clear, realistic guide to saving humanity and life on earth in ethical manner.
Evaluation of Clinical Findings with MRI Venography in Patients with
Idiopatic Intracranial Hypertension
Authors: Aksu Yusuf , Tiryaki Şaban
Published: May 2022

Objectives:

To evaluate clinical data and Magnetic Resonance Venography (MRV) findings
together in patients with idiopathic intracranial hypertension (IIH).

Materials and Methods:

In this retrospective study between January 2009 and February 2021, conventional
MRI and MRV examinations were performed on 30 patients who were admitted to the neurology
service of Erciyes University Medical Faculty with the pre-diagnosis of IIH, cerebrospinal fluid (CSF)
pressure was measured in these patients to confirm the diagnosis of IIH. Transverse Sinus Stenosis
Ratio (TS SR), Superior Sagittal Sinus (SSS) diameter, Sinus Rectus (SR) diameter, Stenosis Segment
Length (SSL) were studied.

Results:

High CSF pressure was detected in 22 of 30 patients with IIH pre-diagnosis. CSF pressure
was normal in 8 cases. TS SR was compared in all groups, right TS SR 0.63 ± 0.16, Left TS SR 0.55 ±
0.16 in the patient group with IIH, right TS SR 0.55 ±0.16 in the CSF pressure normal patient group,
Right TS SR 0.28 ± 0.07 Left TS SR 0.31 ± 0.07 in the control group Right TS SR It was 0.28 ± 0.09,
Sol TS SR was 0.30 ± 0.07.

Conclusion:

Before LP, the cranial venous system must be monitored. TS SR and CSF pressure are
directly proportional. The stenosis rate is important for IIH rather than SSL.
Radiographic, CT, and MRI Features of Generalized Lymphatic Anomaly
in a Boy
Authors: Ding Changwei , Wang Yue
Published: May 2022

Background:

Generalized lymphatic anomaly (GLA) is a rare condition, mainly involving bones, soft tissue, and internal organs. The diagnosis of GLA is often difficult.

Case presentation:

We report a case of GLA in a boy who was initially treated for suspected Langerhans cell histiocytosis and discuss the potential imaging features of GLA. The clinical and imaging data of a case of GLA in an 8-year-old boy were analyzed retrospectively, and the literature was reviewed.

Results:

The case shows that it may be the imaging features of GLA that multiskeletal diffuse expansile cystic osteolytic lesions penetrate the cortical surface and extend within the cortex and the pumice-like or rotten wood-like rough appearance is on volume-rendered 3D CT images, and that MRI reveals their cystic nature. Soft tissue multi-cystic masses increase diagnostic confidence. Fatty infiltration of multiple vertebral bodies and sternum, namely, abnormal T1 and T2 hyperintense and fat-suppressed T2 hypointense on MRI and the corresponding low density similar to that of fat on CT, suggests that GLA involves the vertebrae and sternum, which may be accompanied by chylothorax.

Conclusion:

GLA in bone has typical features on CT. MRI reveals its cystic nature, and typical soft tissue lesions and chylothorax increase confidence in diagnosis.
A Rare Neck Pathology in Children; Congenital Sıalocutanous Fistule: A Case Report
Authors: Deniz Muhammed Akif
Published: May 2022

Introduction/Background:

In this article, we aimed to present a congenital sialocutaneous
fistula originating from the parotid gland in a 4-year-old child with MR findings.

Case Presentation:

A 4-year-old male patient was admitted to our clinic with a small hole in the inferior
right half of the neck and a sticky fluid coming out of this area. Neck ultrasonography (US) and
contrast neck Magnetic Resonance Imaging (MRI) were performed on the patient.
In the US, a millimeter linear, vaguely hypoechoic appearance was observed in the subcutaneous tissue
at this level on the neck. In contrast-enhanced neck MRI imaging, at the level of the right parotid tail, a
millimetric linear fistula tract was observed, which was thought to originate from the superficial parotid
lobe and extended to the skin at the proximal level of the right sternocleidomastoid (SCM) muscle.
After suppressing surrounding fatty tissues in fat-suppressed contrast-enhanced series, this tract area
became slightly pronounced.

Conclusion:

In conclusion, sialocutaneous fistula should be considered among the differential diagnoses
in cases of skin fistulization in children. In terms of differential diagnosis, MRI is a very effective
imaging method due to its high soft-tissue resolution.
L-Proline Catalyzed Knoevenagel Condensation of Aldehydes with Active
Methylene Compounds and Their Molecular Modeling Studies for
Anti-SARS CoV-2 Potentials
Authors: Thorat Bapu R. , Nagre Dnyaneshwar T. , Dhurandhar Pawan P. , Borase Pratiksha K. , Bavkar Sweta , Kasar Riddhi R. , Narkar Rohan D. , Farooqui Mazhar , Mali Suraj N.
Published: May 2022

Introduction:

An efficient one-pot synthesis of 2-alkylidene/arylidene derivatives was reported
from active methylene compounds such as malononitrile/ethyl cyanoacetate/5-methyl-2,4-
dihydro-3H-pyrazol-3-one and aldehydes in the presence of 10 mol% of L-proline (ethanol at room
temperature).

Methods:

All derivatives were obtained in good to excellent yields. The structures of the synthesized
compounds were confirmed from their FTIR (Fourier-transform infrared spectroscopy), 1H-NMR (Proton
nuclear magnetic resonance), and mass spectroscopy. The importance of these compounds is predicted
from their SAR (structure-activity relationship) study. Moreover, these newer compounds were
further docked into various therapeutic targets of the SARS-CoV-2 (severe acute respiratory syndromerelated
coronavirus) virus.

Results:

Results from our molecular docking suggest that these compounds have good inhibitory properties
on the SARS- CoV-2 virus.

Conclusion:

L-proline (bifunctional organic catalyst) is found to be the best catalyst for the synthesis of
different condensed products from active methylene compounds and aldehydes.
Erythroxylum cuneatum Prevented Cellular Adaptation in Morphineinduced
Neuroblastoma Cells
Authors: Moklas Mohamad Aris Mohd , Suliman Noor Azuin , Taib Che Norma Mat , Hidayat Baharuldin Mohamad Taufik , Chiroma Musa Samaila
Published: May 2022

Background:

Chronic morphine stimulates prolonged stimulation of opioid receptors,
especially μ-opioid subtype (MOR), which in turn signals cellular adaptation. However, the
sudden termination of the use of morphine after chronic intake causes the withdrawal syndrome.

Objectives:

Hence, this study was designed to find an alternative treatment for morphine
withdrawal using the alkaloid leaf extract of Erythroxylum cuneatum (E. cuneatum) for the
treatment of morphine-exposed neuroblastoma cell lines.

Methods:

SK-N-SH, a commercialised neuroblastoma cell line, was used in two separate study
designs; the antagonistic and pre-treatment of morphine. The antagonistic treatment was conducted
through concurrent exposure of the cells to morphine and E. cuneatum or morphine and methadone
for 24 hrs. The pre-treatment design was carried out by exposing the cells to morphine for 24 hrs,
followed by 24 hrs exposure to E. cuneatum or methadone. The cytosolic fraction was collected
and assessed for proteins expression involved in cellular adaptation, including mitogen-activated
protein (MAP)/extracellular signal-regulated (ERK) kinase 1/2 (MEK 1/2), extracellular signalregulated
kinase 2 (ERK 2), cAMP-dependent protein kinase (PKA) and protein kinases C (PKC).

Results:

The antagonistic treatment showed the normal level of MEK 1/2, ERK 2, PKA and PKC
by the combination treatment of morphine and E. cuneatum, comparable to the combination of
morphine and methadone. Neuroblastoma cells exposed to morphine pre-treatment expressed a
high level of MEK 1/2, ERK 2, PKA and PKC, while the treatments with E. cuneatum and methadone
normalised the expression of the cellular adaptation proteins.

Conclusion:

E. cuneatum exerted anti-addiction properties by lowering the levels of cellular adaptation
proteins it’s effects is comparable to that of methadone (an established anti-addiction drug).
Treatment of Major Depression with Psychotic Features and Cotard’s
Syndrome after COVID-19 Infection in a Previously Healthy Patient: A
Case Report
Authors: Aytac Hasan Mervan
Published: May 2022

Background:

COVID-19 pandemic is related to anxiety, depression, and psychotic symptoms
either directly due to invasion or inflammation caused by the virus or indirectly due to related
psychosocial stress: fear of infection, social isolation, and financial burden.

Case Presentation:

We present a 28-year-old female case of post‐COVID major depression with psychotic
features and Cotard’s syndrome with no previous psychiatric history. Her complaints initially
described the sadness of mood with early morning worsening, diminished interest in almost all activities,
anhedonia, increased anxiety, ideas of worthlessness, hopelessness, guilt, decreased sleep, and appetite.
Then, she developed severe depression with psychotic features such as delusions of persecution, poverty,
and nihilism. Nihilistic delusions included a description of everything coming to an end. She thought that
her organs were no more working. Later, she negated her existence and started believing that she was
dead. The patient recovered after a combination of sertraline and olanzapine treatment.

Conclusions:

This case of a COVID-19 patient with psychotic depression and Cotard’s delusion highlights
the importance of evaluating mental health status and may contribute to our understanding of the
potential risk of central nervous system impairment by SARS-CoV-2 infection.
Effective Connectivity Between the Orbitofrontal Cortex and the Precuneus
Differentiates Major Psychiatric Disorders: Results from a Transdiagnostic
Spectral DCM Study
Authors: Rema João Paulo , Novais Filipa , Telles-Correia Diogo
Published: May 2022

Translational psychiatry has been a hot topic in neurosciences research. The authors present
a commentary on the relevant findings from a transdiagnostic study applicable to clinic practice. Additional
discussion on conceptual and clinical insight into this current broad line of research is explored
in the integration of multi-level paradigm in Psychiatry research.
Efecto de diferentes tipos de fertilizantes en el crecimiento del maíz criollo, Capachi morado, en el municipio de Andes, Antioquia
Authors: Cardona Restrepo Karen Tatiana , Escobar Posada Esteban Augusto , Ramírez Franco Liliana Andrea , Rivera Hernández Juan Felipe
Published: May 2022

El genotipo de maíz criollo Capachi morado, ha sido conservado y cultivado en el municipio de Andes, Antioquia; sin embargo, existen pocos estudios sobre su comportamiento en la zona. El objetivo de la investigación fue evaluar el crecimiento del maíz Capachi morado en respuesta a la aplicación de diferentes fuentes de fertilizantes. Se realizó un diseño completamente al azar, con 6 tratamientos y 12 repeticiones. Los tratamientos empleados fueron: Tratamiento 1 (micorriza 30 g/planta). Tratamiento 2 (fertilizante orgánico mineral BP-150, aplicando 30, 40 y 50 cc/planta. Tratamiento 3 (micorrizas + BP-150). Tratamiento 4 (Triple 15, aplicando 5, 10 y 15 g/planta). Tratamiento 5 (micorrizas + Triple 15) y Tratamiento 6 (Testigo). Las aplicaciones de Triple 15 y BP-150, se realizaron a los 14, 29 y 43 días después de la siembra, respectivamente. El ensayo fue establecido durante 58 días, se midieron las variables altura de la planta, diámetro de la copa y longitud de raíz. A su vez, se determinaron los datos de Materia Seca (MS) y Área Foliar (AF), para estimar los índices de crecimiento, Índice de Área Foliar (IAF), Tasa de Asimilación Neta (TAN) y Tasa de Crecimiento del Cultivo (TCC). Los tratamientos que obtuvieron mejores resultados en cuanto a las variables altura de la planta, diámetro de la copa, MS, AF, TAN y TCC fueron el T4 (Triple 15) y T5 (Triple 15 más micorrizas). Se concluyó que, la aplicación de fertilizante químico con las dosis recomendadas promueve el crecimiento de las plantas de maíz Capachi morado.
Analysis of Gravity-Filtration Preparation Methods’ Antioxidant Content, Capacity, and Coffee Beverage Acceptance
Authors: Ormaza-Zapata Angela María , Díaz-Arango Félix Octavio , Rojano Benjamín Alberto
Published: May 2022

Most gravity-filtration coffee preparation methods constitute good alternatives for obtaining coffee with varying acidity, bitterness, and bodies. The present study identifies the composition of compounds with antioxidant capacities and cup profiles for coffee beverages prepared using eight gravity-filtration methods. UV-visible spectrophotometry and high-performance liquid chromatography  quantified antioxidants, hydroxycinnamic acids, and antioxidant activity. A qualitative descriptive analysis was performed using an expert panel to establish the sensory quality. The methods that yielded the highest total phenol and flavonoid concentrations were Chemex, Siphon, and Silvertone. The Silvertone, Siphon, and Neapolitan methods had the most condensed tannin content. The maximum hydroxycinnamic acid content was found with the Siphon and Neapolitan methods. Antioxidant capacity was evaluated by the ABTS (antioxidant capacity of the cationic radical 2,2-Azino-bis-3-ethylbenzthiazoline-6-sulfonic acid), ORAC (Oxygen Radical Absorption Capacity), and FRAP (Ferric Reducing Antioxidant Power) methods and found to be the highest with the Silvertone, Siphon, and Neapolitan methods. The preparation methods with the highest sensorial scores were Silvertone and Chemex, while the lowest sensorial acceptance level was found with the Cloth filter method. Beverages made with the Kalita and Drip methods showed the lowest antioxidant compound expressions. The most predominant hydroxycinnamic acid was chlorogenic acid in the eight preparations studied. We thus recommend that coffee be consumed following preparation with the Silvertone, Siphon, or Neapolitan methods to increase antioxidant consumption in the diet. Should the consumer prefer bitter notes, these may be found with the Silvertone preparation method; otherwise, one may enjoy acidic notes in coffee beverages with the Siphon and Neapolitan methods.