bluuebunny/crossref_metadata_2025 huggingface dataset:
Atomic-Scale Structural Properties in NiCo2O4/CuFe2O4 Bilayer Heterostructures on (001)-MgAl2O4 Substrate Regulated by Film Thickness
Authors: Liu Kun , Zhang Ruyi , Li Jiankang , Zhang Songyou
Published: January 2024

Changing the film thickness to manipulate the microstructural properties has been considered as a potential method in practical application. Here, we report that atomic-scale structural properties regulated by film thickness in NiCO2O4(NCO)/CuFe2O4(CFO) bilayer heterostructure prepared on (001)-MgAl2O4 (MAO) substrate by means of aberration-corrected scanning transmission electron microscopy (STEM). The misfit dislocations at NCO/CFO interface and antiphase boundaries (APBs) bound to dislocations within the films both are found in NCO (40 nm)/CFO (40 nm)/MAO heterostructure to contribute to relaxation of mismatch lattice strain. In addition, the non-overlapping a/4[101]-APB is found and the structural transformation of this kind of APB is resolved at atomic scale. In contrast, only the interfacial dislocations form at interface without the formation of APBs within the films in NCO (10 nm)/CFO (40 nm)/MAO heterostructure. Our results provide evidence that formation of microstructural defects can be regulated by changing film thickness to tune magnetic properties of epitaxial bilayer spinel oxide films.
Indentation of Commercial Pure Titanium Processed by Hot Rolling
Authors: Zhou Diaoyu , Yu Jiasheng , Dong Yiwei , Qin Yalu , Hao Xinwei
Published: January 2024

Effects of plastic deformation on the indentation feature of hot-rolled commercial pure titanium alloy were detected using microindentation. It was found that the most deformed sample experienced the largest indentation resistance and had the maximum dislocation density and the indentation size influenced the CP-Ti indentation feature. The Vicker hardness and energy dissipated demonstrated the significant influence of the dislocation motion and size effects on the indentation in the indentation deformation. The linear relation of the energy ratio which is related to the microstructures and the indentation depth ratio was obtained for hcp materials Titanium alloys.
STUDI KERUANGAN KEDAI KOPI DAN EKONOMI KOGNITIF-BUDAYA DI KOTA SURAKARTA TAHUN 2019 (Suplemen Materi Bahan Ajar Geografi SMA Kelas X Kurikulum 2013 pada Kompetensi Dasar 3.1. Memahami Pengetahuan Dasar Geografi dan Terapannya dalam Kehidupan Sehari–Hari)
Authors: Trianingsih Wahyu , Yusup Yasin , Utomowati Rahning
Published: January 2024

This research aims to : (1) determine the distribution of coffee shops in

Surakarta in 2019 (2) determine the relationship of coffee shop distribution witheconomic dominance in Surakarta in 2019 (3) determine the characteristics ofcoffee shop visitors in Surakarta in 2019. This research is a quantitative research.

The approach in this study is a spatial approach is a map. the results of the researchit can be seen that : (1) The distribution of coffee shops is mostly found in LaweyanDistrict because Laweyan District is an urban center which is the center ofcommunity activity. (2) There is a positive correlation between the distribution ofcoffee shops with the dominance of cognitive-cultural economy. (3) Coffee shopvisitors are residents of productive age, including the upper middle class.
Penentuan Lahan Kritis Sebagai Arahan Konservasi Lahan di Kecamatan Ngargoyoso Kabupaten Karanganyar Tahun 2021
Authors: Widyawati Anita Wahyu , Ahmad Ahmad , Nugraha Setya
Published: January 2024

Tujuan dari penelitian ini yaitu (1) Menganalisis kesesuaian penggunan lahan dengan fungsi kawasan di Kecamatan Ngargoyoso Tahun 2021 (2) Menganalisis kesesuaian pola ruang RTRW dengan fungsi kawasan di Kecamatan Ngargoyoso Tahun 2021 (3) Menganalisis tingkat kekritisan lahan di Kecamatan Ngargoyoso Tahun 202 (4) Menganalisis arahan konservasi lahan di Kecamatan Ngargoyoso Tahun 2021. Penelitian merupakan penelitian kualitatif dengan menggunakan metode survei. Populasi dalam penelitian adalah satuan lahan. Unit analisis yang digunakan adalah satuan lahan. Pengambilan sampel pada penelitian ini menggunakan sampel jenuh. Pengumpulan data pada penelitian ini dilakukan melalui observasi lapangan, interpretasi citra, uji laboratorium, wawancara, dan studi dokumentasi. Teknik analisis yang digunakan pada penelitian ini yaitu skoring parameter fungsi kawasan dan tingkat kekritisan lahan, analisis deskriptif hasil overlay peta, dan pengelompokan arahan konservasi lahan berdasarkan fungsi kawasan dan tingkat kekritisan lahan. Hasil penelitian ini menunjukkan bahwa (1) Kecamatan Ngargoyoso mempunyai empat fungsi kawasan yaitu kawasan lindung, kawasan penyangga, kawasan budidaya tanaman tahunan, serta kawasan budidaya tanaman semusim dan permukiman. Kesesuaian penggunaan lahan dengan fungsi kawasan menunjukan bahwa sebagian besar penggunaan lahan di Kecamatan Ngargoyoso tidak sesuai dengan fungsi kawasaannya seluas 4.162,523 Ha (67,79 %). (2) Kesesuaian pola ruang RTRW dengan fungsi kawasannya menunjukkan bahwa sebagian besar pola ruang RTRW sesuai dengan fungsi kawasannya seluas 4.413,048 Ha (71,87%). (3) Tingkat kekritisan lahan di Kecamatan Ngargoyoso diklasifikasikan menjadi empat yaitu potensial kritis, agak kritis, kritis, dan sangat kritis. (4) Arahan konservasi metode vegetatif yang dapat diterapkan di Kecamatan Ngargoyoso meliputi pengelolaan tanah minimum, hutan lindung/hutan kemasyarakatan/hutan suaka alam/hutan wisata, penanaman vegetasi permanen, penanaman penutup tanah, hutan produksi terbatas/hutan rakyat, agroforestry, penanaman menurut garis kontur, penanaman menurut strip, dan pertanaman lorong, strip rumput, manajemen bahan organik, pertanaman campuran, dan tanaman pagar/pagar hidup. Arahan konservasi metode mekanik/teknik sipil meliputi teras gunung/saluran pengelak, saluran pembuangan air (SPA), bangunan terjunan, kontrol sedimen, teras guludan, teras bangku, teras individu, rorak, dan mulsa vertikal.
Pengembangan Multimedia Pembelajaran Dengan Aplikasi Lectora Inspire Pada Materi Bumi Sebagai Ruang Kehidupan di Kelas X SMA Negeri 5 Surakarta
Authors: Nu'mah Azidatul Khairatin , Subandriyo Djoko , Prihadi Singgih
Published: January 2024

The aim of this research are to knows (1) To determine the feasibility of developing multimedia learning applications for Lectora Inspire on earth material as a space of life in class X IPS SMA N 5 Surakarta. (2) Knowing the effectiveness of multimedia learning Lectora Inspire applications on the material of the earth as a space of life after being implemented in class X IPS SMA N 5 Surakarta.

The research method used in this research is the research and development method with ADDIE development models namely Analyze, Design, Development, Evaluation and Implementation. Data collection techniques with interviews, questionnaires, tests and documentation. Data analysis techniques with multimedia feasibility analysis of the questionnaire by the validator and calculation of effectiveness with the T test with a confidence level of 5% of the data that has been calculated with the normality test.

Based on data analysis, the results of the research are known as follows: (1) Multimedia learning of Lectora Inspire applications on the material Earth as Life Space in class X SMA N 5 Surakarta is feasible to use by obtaining a value of 5 (very feasible) based on the results of validation. (2) Multimedia learning application of Lectora Inspire on the material of Earth as Life Space in class X SMA N 5 Surakarta is effective to be used in the learning process based on the T Test to obtain the results of Sig. (2-tailed) is 0,000 so less than 0.05 then Ho is rejected and Ha is accepted.

 

Keywords : Development of Learning Multimedia, Lectora Inspire, ADDIE, Earth as Life Space.
Enhancing Fault Detection and Classification in Grid-Tied Solar Energy Systems Using Radial Basis Function and Fuzzy Logic-Controlled Data Switch
Authors: Calinao Jr. Hilario A. , Gustilo Reggie C. , Dadios Elmer P. , Concepcion II Ronnie S.
Published: January 2024

This study integrates fuzzy logic-controlled data switching and the radial basis function neural network (RBFNN) for fault detection and classification in grid-tied solar energy systems. The fuzzy logic controller filters out invalid sensor data through a data switch, ensuring that the fault detection and classification system receives reliable input. Training data were prepared through data normalization using the z-score function and principal component analysis, thereby reducing data complexity and standardizing the inputs. The resulting RBFNN model exhibited a low mean squared error with a value of 7.67×10-4, indicating its ability to classify faults based on the actual system scenarios. Performance evaluation metrics, including accuracy, precision, recall, and F1-score, were used to assess the effectiveness of the RBFNN model. The model demonstrated high accuracy (96.4%), precision (98.281%), recall (98.013%), and F1-score (98.147%), indicating the suitability and effectiveness of the RBFNN model to identify and classify faults in grid-tied solar energy systems.
Patellar Tendon Reconstruction After Failed Primary Repair of Bilateral Ruptures
Authors: Husen Martin , Krych Aaron J. , Poudel Keshav , Stuart Michael J.
Published: January 2024

Case:

A 29-year-old man sustained a bilateral acute patellar tendon rupture (PTR) while jumping on a trampoline. He was initially treated with bilateral transosseous patellar tendon repairs. Bilateral rerupture occurred during a fall 10 weeks after. He subsequently underwent staged bilateral patellar tendon reconstructions using an Achilles tendon allograft. At 3-year follow-up, he has maintained full range of motion and leg strength without rerupture or other complications.

Conclusion:

The use of Achilles tendon allograft in the presence of inadequate and poor-quality tendon tissue for reconstruction of the patellar tendon in the revision setting is a viable and effective treatment option.
Penggunaan Pasir Silika Sebagai Bahan Pembuatan Paving Block
Authors: Mulyati Mulyati , Fakhri Jovari Ibrahim
Published: January 2024

Penelitian ini menggunakan pasir silika sebagai bahan pembuatan paving block. Tujuan dari penelitian ini adalah untuk mengetahui nilai kuat tekan dan penyerapan air paving block dari penggunaan pasir silika sebagai bahan pengganti sebagian pasir dalam pembuatan paving block.   Bahan campuran pembutan paving block digunakan perbandingan 1 bagian semen dan 3 bagian pasir, dengan variasi penggunaan pasir silika adalah 0%, 5%, 10%, 15%, dan 20%.  Pembuatan benda uji paving block dilakukan secara manual dengan ukuran cetakan 21 cm x 10,5 cm x 6 cm.  Pengujian kuat tekan dan penyerapan air paving block dilakukan pada umur 28 hari.  Hasil penelitian pembuatan benda uji paving block dengan menggunakan pasir diperoleh kuat tekan rata-rata sebesar 8,81 MPa dan penyerapan air rata-rata sebesar 15%, dengan menggunakan pasir silika 5%, 10%, 15%, dan 20% diperoleh kuat tekan rata-rata berturut-turut sebesar 9,56 MPa, 11 MPa, 13,5 MPa, 14,94 MPa, dan penyerapan air rata-rata berturut-turut sebesar 13%, 10,1%, 9,5%, 9,2%.  Dengan demikian penggunaan pasir silika sebagai pengganti pasir dalam pembuatan paving block dapat meningkatkan kuat tekan dan menurunkan penyerapan air paving block.
Wavelet-Attention Swin for Automatic Diabetic Retinopathy Classification
Authors: Dihin Rasha Ali , AlShemmary Ebtesam N. , Al-Jawher Waleed A. M.
Published: January 2024

اعتلال الشبكية السكري (DR) هو أحد مضاعفات مرض السكري الذي يؤثر على العين عن طريق إتلاف الأوعية الدموية في شبكية العين. يمكن أن يؤدي ارتفاع مستويات السكر في الدم إلى تسرب أو انسداد هذه الأوعية ، مما يؤدي إلى فقدان البصر أو العمى. يعد الاكتشاف المبكر لـ DR أمرًا ضروريًا لمنع العمى ، ولكن التحليل اليدوي لصور قاع العين يمكن أن يستغرق وقتًا طويلاً ، خاصة مع عدد كبير من الصور. اكتسبت Swin-Transformers شعبية في تحليل الصور الطبية ، مما أدى إلى تقليل الحسابات وتحقيق نتائج أفضل. تقدم هذه الورقة WT Attention-Db5 Block ، والتي تركز الانتباه على مجال التردد العالي باستخدام تحويل المويجات المنفصل (DWT). تستخرج هذه الكتلة معلومات مفصلة من مجال التردد العالي مع الاحتفاظ بالمعلومات الأساسية منخفضة التردد. تناقش الدراسة نتائج تحدي كشف العمى لعام 2019 (APTOS 2019 BD) الذي عقدته جمعية آسيا والمحيط الهادئ لطب العيون عن بُعد. يحقق نموذج WT-Swin المقترح تحسينات كبيرة في دقة التصنيف. بالنسبة إلى Swin-T ، تبلغ دقة التدريب والتحقق من الصحة 99.14٪ و 98.91٪ على التوالي. بالنسبة للتصنيف الثنائي باستخدام Swin-B ، تبلغ دقة التدريب 99.01٪ ، ودقة التحقق 99.18٪ ، ودقة الاختبار 98٪. في التصنيف المتعدد ، تبلغ دقة التدريب والتحقق 93.19٪ و 86.34٪ على التوالي ، بينما تبلغ دقة الاختبار 86٪. في الختام ، يعد الاكتشاف المبكر لـ DR ضروريًا لمنع فقدان البصر. تُظهر كتلة WT Attention-Db5 المدمجة في نموذج WT-Swin نتائج واعدة في دقة التصنيف.
Synthesis, Structural, Morphological Characterization, and Cytotoxicity Assays of Metal Complexes Decorated SiO2 Nanoparticles Against Breast Cancer Cell Lines (MDA-MB-231)
Authors: Ahmed Alya'a J. , Alias Mahasin F.
Published: January 2024

في هذا البحث تم تحضير المركبات المعدنية الجديدة لأيونات البلاتين (الرباعي) و الذهب (الثلاثي) مع ليكاند قاعدة مانخ جديد مشتق من السيبروفلوكساسين . تم استخدام المعقدات بعد ذلك كمصدر  لتحضير جزيئات                              عن طريق ترسيب المعقدات على مسام دقائق السيليكا النانوية.                                                                      Si/Au2O3 Si/PtO2
 تم تشخيص الليكاند و معقداته باستخدام أطياف الاشعة تحت الحمراء، الاشعة فوق البنفسجية ، التحليل الدقيق للعناصر، التوصيلية المولارية و درجة الانصهارمن النتائج تبين ان الصيغة العامة للمعقدات هي  :                                                                                                      
، والشكل ثماني السطوح                                   n= 1,2, L= ليكاند قاعدة مانخ, M = Au(III) ,Pt(IV), [M(L)2Cl2] Cl(n).H2O
  تم تشخيص التركيب الكيميائي و المورفولوجي لدقائق الاكاسيد النانوية باستخدام أطياف الاشعة تحت الحمراء، حيود الاشعة السينية ، المجهر الالكتروني الماسح ، المجهر الالكتروني النافذ و مجهر القوة الذرية. في الخطوة التالية ، تم اختبار الليكاند و معقداته و الاكاسيد النانوية كعامل مضاد للسرطان لخطوط خلايا سرطان الثدي .  اظهرت النتائج أن المعقدات  والاكاسيد النانوية واعدة أكثر بأن تستخدم كمضادات للسرطان في المستقبل خاصة عند التراكيز العالية  .
Development of IIOT-Based Pd-Maas Using RNN-LSTM Model with Jelly Fish Optimization in the Indian Ship Building Industry
Authors: Rao PNV Srinivasa , Jayasree PVY
Published: January 2024

المشكلة: يعتبر بناء وإصلاح السفن من الصناعات دائمة الخضرة على المستوى الوطني والعالمي. تخضع السفن عمومًا للإصلاحات الدورية المقررة من قبل صناعات بناء السفن الهندية. في بعض الأحيان تفتقر الصناعات إلى الإنتاجية ويفتقر إلى التحديث ويجب اتباع بعض الأساليب الحديثة.  الهدف: تركز الدراسة على تحسين الصيانة التنبؤية كخدمة على إنترنت الأشياء الصناعي من خلال خوارزميات التعلم الآلي. المساهمة الرئيسية للدراسة هي استخدام تقنيات التحسين لاختيار الميزات وRNN-LSTM لتحسين الدقة. الأساليب: تتم معالجة مجموعة البيانات المحددة مسبقًا واختيار الميزات لتحسين الدقة، ويتم تحسين اتخاذ القرار الآلي في إطار الشبكة العصبية التلافيفية جنبًا إلى جنب مع مصنف الأشجار المعزز للمجموعة الذي تم تطويره باستخدام تحسين قنديل البحر والعصبية المتكررة. نموذج الشبكة والذاكرة طويلة المدى (RNN-LSTM) للتعرف على الأنماط والمتجهات الرقمية في بيانات العالم الحقيقي بعد معالجة المخرجات ثم يتم إرسالها مرة أخرى كمدخل للشبكة المتكررة لاتخاذ القرار في السفينة عملية البناء.  النتائج: من خلال تقييم نتائج الأداء ومصفوفة الارتباك من خلال مخرجات التدريب والاختبار، يتم تصنيف جميع مقاييس التدريب والاختبار في مصفوفة الارتباك. يمكن أن يساعد نموذج الصيانة التنبؤية المقترح بدقة عالية للكشف عن الأعطال في المراحل المبكرة وصيانة السفن الهندية في تجنب وقوع الحوادث في الرحلات وفقدان البضائع والأموال أثناء النقل. يوضح التحقق من صحة نموذج الصيانة التنبؤية المقترح باستخدام أنواع مختلفة من خوارزميات التعلم العميق أن منهجيتنا المقترحة تعطي دقة محسنة بنسبة 98.9336% وهي أعلى من أي نماذج أخرى  الاستنتاج: يساعد نظام Pd-MaaS المقترح في الكشف المبكر عن الأعطال في السفن والتي تعد أكبر ميزة في صناعة بناء السفن الهندية.
The Late Cambrian to Neogene Evolution of the Khanom Core Complex (Peninsular Thailand)
Authors: Klötzli Urs S. , Neugschwentner Bernhard , Burda Jolanta , Kanjanapayont Pitsanupong , Li Qiu-Li , Liu Yu , Konečný Patrik , Charusiri Punya
Published: January 2024

The Khanom Core Complex in Peninsular Thailand is a part of the crystalline basement of Sundaland and plays a key role in our understanding of the evolution of Thailand and SE Asia. The complex comprises ortho- and paragneisses, schists, meta-volcanics, subordinate calcsilicate rocks, and postkinematic granitoids. New petrochronological data reveal that the sedimentation and metamorphism of the paragneiss precursors (Haad Nai Phlao complex, Khao Yoi paragneisses) occurred in the Late Cambrian at the latest. A syn- to postsedimentary andesitic intrusion/extrusion in the Haad Nai Phlao complex at 495 ± 10 Ma defines a minimum age for the former event(s). In the Early Ordovician (477 ± 7 Ma), the Haad Nai Phlao complex and the Khao Yoi paragneisses were intruded by the Khao Dat Fa granite. During the Indosinian orogenic events, the Laem Thong Yang (211 ± 2 Ma) and Haad Nai Phlao (210 ± 2 Ma) granitoid plutons were intruded. Immediately afterward (ca. 208–205 Ma), the first metamorphic overprinting of the Laem Thong Yang granite and the Haad Nai Phlao complex including the Khao Dat Fa granite occurred. A second metamorphic overprinting of all lithological units and the contemporaneous intrusion of the Khao Pret granite followed in the Late Cretaceous and Early Paleogene (ca. 80–68 Ma). The tectonic formation of the core complex took place in the Eocene (<42 Ma), followed by exhumation and regional cooling below ca. 450°C and the latest cooling to ca. 120°C in the Miocene (ca. 20 Ma). The evolutionary data show that the Khanom Core Complex is part of Sibumasu, and its Late Cretaceous-Neogene cooling pattern and exhumation history can be directly related to the northward drift of India.
Uma experiência com aplicação de roteiro de atividade investigativa no GeoGebra
Authors: May Lisiane , Predebon Titon Flaviane , Duarte de Souza Lindomar
Published: January 2024

Este trabalho aborda a escrita de um Relato de Experiência, oriundo de atividades desenvolvidas no âmbito da participação de uma estudante de licenciatura no Programa de Residência Pedagógica (PRP), Subprojeto Matemática Concórdia, do Instituto Federal Catarinense (IFC), Edital 24/2022 CAPES. A participação no PRP se deu entre a sexta e a oitava fase do curso de Licenciatura em Matemática do IFC, no decorrer de dois módulos do programa (Módulos I e II). Nesse contexto, é apresentado um panorama geral sobre a vivência no PRP entre outubro de 2022 a setembro de 2023, as atividades desenvolvidas (observação, planejamentos, regências, participações em conselhos de classe, formações e projetos de ensino e pesquisa) e uma experiência pontual, a qual intenta apresentar a experiência de aplicação de um roteiro de Investigação Matemática com a utilização do software GeoGebra enquanto recurso tecnológico. A experiência que associa as metodologias e tendências da Educação Matemática foi considerada como um dos momentos formativos de maior destaque, em virtude de ser a regência mais ativa e interessante do ponto de vista da professora/residente como dos alunos. Ambos tiveram que se desafiar e buscar conhecimento, conseguindo compreender melhor o conteúdo através da tecnologia. Por fim, faz-se uma reflexão sobre a participação e a importância do PRP e o papel formativo deste espaço-tempo na constituição profissional docente.
Coordenação dos registros algébrico e gráfico no estudo das funções seno e cosseno em um livro didático do ensino médio sob a perspectiva da Teoria dos Registros de Representação Semiótica
Authors: Brandl Eduardo , Gonçalves Lenartovicz Ilizete , Pavanello Júlia
Published: January 2024

Este artigo apresenta algumas reflexões sobre a abordagem do objeto matemático funções trigonométricas seno e cosseno em um livro didático de Matemática do Ensino Médio. De modo específico, a pesquisa teve como objetivo analisar a presença e a mobilização entre os registros algébrico e gráfico na apresentação deste conteúdo e nas atividades propostas pelo livro didático, de forma a verificar se elas contribuem para a coordenação entre estes registros sob a perspectiva da Teoria dos Registros de Representação Semiótica. Esta teoria desenvolvida por Raymond Duval tem se mostrado importante por considerar as especificidades do conhecimento matemático, pois tem como pressuposto que o acesso aos objetos matemáticos se dá exclusivamente por meio de suas representações, sendo necessária a apreensão de diferentes registros e a coordenação entre eles para a compreensão do objeto matemático em estudo. Os critérios de análise foram organizados de acordo com a referida teoria e a análise mostrou que há correlação com a Teoria de Duval, pois o livro didático busca apresentar alguns aspectos que remetem a esta teoria, no entanto apresenta parcialmente a abordagem de interpretação global de propriedades figurais no tratamento gráfico. Também não explorou todas as possibilidades de relação entre as unidades significantes do registro algébrico e as variáveis visuais do registro gráfico. Pontua-se ainda que embora a indicação de uso do software GeoGebra tenha constituído um avanço, não foi usado para possibilitar a efetiva coordenação entre os registros.
R scripts for user-friendly DESeq2 RNA-seq differential expression analysis
Authors: Rosa Bruce A , Martin John , Mitreva Makedonka
Published: January 2024

An R script for differential expression testing using DESeq2 is provided along with two example text-format input files, one for read counts and one for sample metadata / groupings. The script includes DESeq2 installation commands, instructions for input file preparation (with examples), loading of input files, specifying comparisons of interest generating differential expression statistics output files, and generating PCA coordinate output files. Comments to help with and explain each step are provided in the script. The script is intended to simplify the process of performing simple RNA-seq differential expression analysis for users who are not familiar with coding in R and streamlines the preparation of simple input files to produce output statistics and PCA plots.
Mapping of long COVID conditions in India: A study protocol for systematic review and meta-analysis
Authors: Jain Nidhi , Shah Komal , Chauhan Roshani , Arora Priyanka , Gupta Abhishek , Saxena Deepak
Published: January 2024

The COVID-19 pandemic has posed significant concern revolves around the prolonged effects experienced by a subset of individuals post-acute sequelae of SARS- COV-2 infection, termed long COVID. This study protocol outlines the methodology for a meta-analysis and systematic review with the objective of comprehensively assessing the prolonged effects of COVID-19 on the Indian population and determine the likely risk factors connected to the development and persistence of long COVID. A comprehensive search strategy will be employed across major databases. By combining data from various studies, the expected outcomes include a clearer understanding and documentation of long-term prevalence rates of COVID, symptom profiles, regional disparities, and potential determinants for long-term COVID conditions within the Indian population. The anticipated findings will contribute to a refined understanding of this condition, guiding healthcare interventions and future research endeavors aimed at mitigating the impact of the long COVID condition on the Indian population.
An EBNA1-YAP signaling axis drives immune escape through CD276 in EBV-associated gastric cancer
Authors: Xu Dazhi , Huang Binhao , Wang Yu , Guo Jing , Duan Yantao , Dou Yi , Kang Wei , Wei Gong-Hong
Published: January 2024

Clinical efficacy of anti-PD1 immunotherapy is often with low response rates in Epstein-Barr virus-associated gastric cancer (EBVaGC). To gain insights into the immune escape and discovering the key molecule against anti-tumor immunity, we performed an immune checkpoint screening with transcriptome profiling and IHC staining data. CD276 was found as an independent immune suppressive molecule and correlated with a worse prognosis. Our in vitro and in vivo experiments showed that CD276 promotes T cell apoptosis and reduces its chemokine secretion, thereby attenuating immune response and promoting tumor progression. Mechanistically, we revealed a chromatin occupancy of YAP/TEAD4 at the regulatory regions of CD276 and confirmed YAP/TEAD-mediated transcriptional upregulation of CD276 in EBVaGC. We further revealed that EBNA1 stimulate the MST1/2-LATS1/2-YAP axis, thus acting on the upstream of YAP activation to drive aberrant CD276 overexpression. Intriguingly, we established humanized xenograft mouse model and observed that EBVaGC with CD276 upregulation showed insensitivity to anti-PD1 immunotherapy while targeting CD276 in combination with PD1 blockade could effectively reduce the tumor size. Collectively, we unraveled the EBNA1-YAP-CD276 axis in promoting immune escape, representing a newly-discovered mechanism in EBVaGC with low response rate to anti-PD1 immunotherapy, and provided a novel insight into a potential immunotherapeutic avenue for EBVaGC treatment.
Organics removal pathways and algae-bacteria interactions of microalgal-bacterial granular sludge treating real municipal wastewater
Authors: Ji Bin , Shi Shi , Xu Chengxiang , Li Anjie , Zhang Xiaoyuan , Liu Yu
Published: January 2024

Algae-bacteria interactions play an essential role in the transformation of complex organics in microalgal-bacterial granular sludge (MBGS), but the intrinsic removal mechanisms have not been well understood. This study thus attempted to investigate the removal performance and mechanisms of complex organics in real municipal wastewater in MBGS process. The results showed that complex organics could be effectively disposed during day-night cycles by MBGS, with the process performance significant impacted by the influent C/N ratio. Further metagenomic and metatranscriptomic analyses revealed that the upregulated gap2 and gpmA genes of glycolysis enhanced the conversion of complex organics to CO2 mediated by Chlorophyceae and Acidobacteriae/Sumerlaeia/Fimbriimonadia, while the upregulated petH gene of NADPH synthesis by Cyanobacteria strengthened the fixation of CO2 into biomass. Meanwhile, the functional gene of amyA in the starch metabolism by Actinobacteriota was upregulated, along with the upregulated gldA gene in the glycerolipid metabolism through Chlorophyceae and Chloroflexia/Verrucomicrobiae. Moreover, a close symbiotic relationship between Cyanobacteria and Desulfobacterota I was identified, which played a crucial role in fatty acid decomposition. This study offers new insights into degradation mechanisms of complex organics via microalgal-bacterial symbiosis, which also gains basic knowledge on the carbon cycle in natural water ecosystems mediated by microalgal-bacterial symbiosis.
Development and application of an artificial intelligence-assisted endoscopy system for diagnosis of Helicobacter pylori infection: a multicenter randomized controlled study
Authors: Zou Pei-Ying , Zhu Jian-Ru , Zhao Zhe , Mei Hao , Zhao Jing-Tao , Sun Wen-Jing , Wang Guo-Hua , Chen Dong-Feng , Fan Li-Lin , lan Chun-Hui
Published: January 2024

Background
The early diagnosis and treatment of Heliobacter pylori gastrointestinal infection provide significant benefits to patients. We constructed a convolutional neural network (CNN) model based on an endoscopic system to diagnose H. pylori infection, and then examined the potential benefit of this model to endoscopists in their diagnosis of H. pylori infection.
Materials and Methods
A CNN neural network system for endoscopic diagnosis of H. pylori infection was established by collecting 7377 endoscopic images from 639 patients. The accuracy, sensitivity, and specificity were determined. Then, a randomized controlled study was used to compare the accuracy of diagnosis of H. pylori infection by endoscopists who were assisted or unassisted by this CNN model.
Results
The deep CNN model for diagnosis of H. pylori infection had an accuracy of 89.6%, a sensitivity of 90.9%, and a specificity of 88.9%. Relative to the group of endoscopists unassisted by AI, the AI-assisted group had better accuracy (92.8% [194/209; 95%CI: 89.3%, 96.4%] vs. 75.6% [158/209; 95%CI: 69.7%, 81.5%]), sensitivity (91.8% [67/73; 95%CI: 85.3%, 98.2%] vs. 78.6% [44/56; 95%CI: 67.5%, 89.7%]), and specificity (93.4% [127/136; 95%CI: 89.2%, 97.6%] vs. 74.5% [114/153; 95%CI: 67.5%, 81.5%]). All of these differences were statistically significant (P < 0.05).
Conclusion
Our AI-assisted system for diagnosis of H. pylori infection has good diagnostic ability, and can improve the accuracy of endoscopists in gastroscopic diagnosis.
Anxiety symptoms and coping strategies used by older adults during COVID-19: A national e-study of linkages among and between them.
Authors: Low Gail , França Alex Bacadini , Gao Zhiwei , Gutman Gloria , von Humboldt Sofia , Allana Hunaina , Wilson Donna Marie
Published: January 2024

Background
During the COVID-19 pandemic older adults experienced a variety of symptoms of anxiety. They employed a number of different strategies to deal with these. The aim of this study was to create a blueprint of older Canadians’ symptoms of pandemic-related anxiety and coping strategies, and linkages among and between them. Particular attention was paid to identifying the most-pernicious symptoms and variables that might facilitate application of the most beneficial coping strategies.
Methods
An e-survey was conducted with 1,327 older Canadians in the Summer of 2022, when public health measures were lifting across Canada. Anxiety was measured using the Geriatric Anxiety Scale − 10. Participants also completed the Coping with Stress and Anxiety personal assessment tool. Network analysis permitted us to examine linkages among respondents’ self-reported symptoms, and between their most pernicious symptoms of anxiety and the strategies to cope with them.
Results
Findings revealed a troubling trio of anxiety symptoms of central importance to our respondents: feelings of restlessness, muscle tension and having no control over their lives. Restless and no control over my life were particularly pernicious because they explained between 64–68% of the variance in 8 other anxiety symptoms. Coping seemed to occur through trial and error. Some strategies appeared to work in tandem and others in opposition to each other. Responders remembering resilience and staying active functioned as bridges shielding older people from worry, restlessness, and tension through spurning other remedial actions.
Discussion
This study provides evidence of a stable and predictable network of anxiety symptoms containing three particularly pernicious symptoms. Coping strategies, some seemingly working in tandem and some in opposition, or as bridges to recovery speak to the complex and arduous nature of mentally healthy recovery work. A visual representation of how anxiety symptoms can operate as a network might help older people better understand their own symptom experiences. Combining the two networks offers a blueprint of what within-person recovery might look like and a visual teaching tool for practitioners and program developers; older people could gain added insight into their own recovery experience.
DIRAS3 might function as a diagnostic biomarker and be related to immune infiltration in gliomas
Authors: Zhou Jinghuan , Liang Qiang , Li Qiao , wang Xudong , Yuan Guoqiang , Pan Yawen
Published: January 2024

Gliomas are not composed of mere tumour cells, but a complex ecosystem with an internal immune-related component called the tumour immune microenvironment, which is closely related to the development of the tumour itself. In order to develop a novel therapy for enhancing prognosis, the goal of this study was to investigate whether DIRAS3 can impact the survival outcome of glioma patients and its potential mechanism.We extracted expression profile and clinical data from TCGA and CGGA databases to investigate the mRNA expression level of DIRAS3 in glioma patients with different clinicopathological characteristics and its effect on overall survival. Then, the expression difference of DIRAS3 in different grades of glioma and normal tissues were verified. GO, KEGG, and GSEA analyses were used to explore the possible biological functions and signal transduction pathways of DIRAS3 and its co-expressed genes. In the end, the relationship between DIRAS3 expression and immune cell infifiltration degree as well as immune-related molecules expression was also explored. Our results indicate that DIRAS3 was significantly overexpressed in gliomas and associated with poorer overall survival. It might influence the infiltration degree of multiple immune cells in the tumor microenvironment by regulating various processes of immune response.
Parametric design and mechanical properties of TPMS porous structure
Authors: Fulong Zhang , Mingbo Pang , Yanzhou Li , Liu Shuangyu , Xi Wang
Published: January 2024

Three-periodic minimal surface (TPMS) metal porous structure is a new lightweight structure with wide applications in multifunctional structures. In order to study the deformation behavior and energy absorption of different structures, three TPMS samples with Diamond, Gyroid, and Primitive structures were prepared using the selective laser melting technique. Then the compression tests were carried out on the specimens and the obtained results show that the deformation of TPMS is dominated by bending deformation. Among the studied structures, the highest ultimate strength and energy absorption capacity was 186.44 MPa and 54MJ/m3， respectively, which was achieved in the Gyroid structure. The Gyroid porous structure deforms uniformly along the loading direction in a lamellar collapse pattern. The performed analyses show that when the strain reaches 30%, a shear band of 45° relative to the compression direction appears. Failures in the Diamond and Primitive structures first occurred at the cell junction, and the shear band appeared at a strain of 20%. Comprehensive analyses showed that different types of TPMS structures have different deformation behaviors and mechanical responses during compression. The results of this article can be used to design impact-resistant parts in vehicles or implants.
Association of the Intake of Nineteen Dietary Fatty Acids With Age-related Macular Degeneration in the US Population
Authors: Jiang Bingcai , Wei Xin , Cai Dongmei , Wang Xiaoqin , Zhou Xiaobo , Chen Feng , Shen Xiaopeng , Cao Xiaochuan , Zheng Changwei
Published: January 2024

PURPOSE:
The aim of this study is to assess the relationship between dietary intake of fatty acids and the risk of age-related macular degeneration (AMD) in the United States population.
METHODS:
Adult participants of the 2005-2008 National Health and Nutrition Examination Survey (NHANES) were included in this nationwide cross-sectional study. The intake of dietary fatty acids was analyzed as a continuous and categorical variable. AMD status was assessed using nonmydriatic fundus photographs. Univariate and multivariate logistic regression analyses were used to assess the association between dietary fatty acid intake and the risk of AMD.
RESULTS:
The unweighted population included 4,702 individuals of whom 374 had AMD. After adjusting for relevant variables, EPA (OR: 0.996, 95% CI: 0.993-0.996, P = 0.018), DPA (OR: 0.976, 95% CI: 0.962-0.990, P = 0.002), and DHA (OR: 0.996, 95% CI: 0.994-0.999, P = 0.003) were significantly associated with the presence of AMD. The highest versus lowest quartile of EPA (OR: 0.476, P for trend < 0.001), DPA (OR: 0.467, P for trend = 0.005) and DHA (OR: 0.586, Pfor trend = 0.008) were negatively correlated with the presence of AMD. Subgroup analysis showed that higher quartiles of EPA (OR: 0.461, P for trend < 0.002), DPA (OR: 0.467, P for trend = 0.006) and DHA (OR: 0.578, P for trend = 0.007) exhibited a negative association with early AMD. The study found no significant association between the intake of dietary fatty acids, including n-3 PUFA, and the risk of late AMD.
CONCLUSIONS:
In the 2005-2008 NHANES population, this study suggested a significant association between higher dietary DHA, DPA and EPA intake and reduced risk for AMD in the US population, particularly for early AMD.
The Moderating Effect of Physical Activity on the Relationship Between Neutrophils and Depression: A Cross-sectional Analysis Based on the NHANES Database
Authors: GUO Zhaohui , XIE Zhenwen , WANG Peng , LI Shufan , XIN Xin , WANG Xing
Published: January 2024

Objective: To analyze the relationship between neutrophil count and depression based on the NHANES database and to explore the moderating effect of physical activity on the relationship between neutrophils and depression.
Methods: Cross-sectional data from the NHANES database were extracted, including demographic information, neutrophil count, scores from the PHQ-9 depression self-assessment scale, and scores from the GPAQ (Global Physical Activity Questionnaire). Pearson correlation, binary logistic regression, restricted cubic spline models, and linear regression equation models were used to analyze the association among physical activity, neutrophil count, and depression.
Results: There was a positive correlation between neutrophil count and depression, with an OR[95%CI] of 1.12[1.011,1.24]. The effect of physical activity in moderating the impact of neutrophils on depression was statistically significant (β=-0.1691, P<0.05).
Conclusion: Identifying depression in adults can be informed by monitoring neutrophil counts, which may be related to the "inflammation-induced depression" theory. Physical activity, as an effective moderator, significantly reduces the impact of neutrophils on depression, offering potential value in future prevention and intervention strategies for depression.
Unraveling the Novel Associations of Sleep Apnea with Glycosylated Hemoglobin: Insights from NHANES and Mendelian Randomization Analysis
Authors: ma zhen , zhao min , zhao huanghong , Qu Nan
Published: January 2024

Background
While sleep apnea (SA) has been identified as a risk factor for metabolic dysfunction in diabetes, further research is required to establish a causal relationship between alterations in glycosylated hemoglobin(HbA1C) and the presence of sleep apnea.
Methods
We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2015–2018 and employed logistic regression models to analyze the association,Based on the questionnaire data, sleep apnea (SA) is categorized into three levels: Rarely−1−2 nights a week, Occasionally−3−4 nights a week, and Frequently−5 or more nights a week. Additionally, a two-sample Mendelian randomization (MR) study was conducted using genome-wide association study (GWAS) summary statistics to assess the causal relationship between sleep apnea and HbA1C. The primary analysis utilized the inverse variance weighted (IVW) method. Sensitivity analyses were also performed to ensure the robustness of our findings.
Results
In our cross-sectional analysis, after adjusting for multiple covariates, we observed an increased risk of HbA1C ratio for both "Occasionally−3−4 nights a week" (OR = 0.08, 95% CI = 0.00 ~ 0.15, P = 0.036) and "Frequently−5 or more nights a week" (OR = 0.09, 95% CI = 0.00 ~ 0.17, P = 0.045). Utilizing the IVW technique, we calculated the risk of sleep apnea on HbA1C to be (OR = 1.086, 95% CI = 0.89 ~ 0.96, P = 0.035). The MR sensitivity analysis generated consistent findings.
Conclusion
Sleep apnea is linked to a higher risk of elevated HbA1c. The MR analysis supports a potential causal effect of sleep apnea on HbA1c.
Characterization of 38 cases of Neurobrucellosis
Authors: Qi Weimin , Niu Xiaoyan , Ren Yazhou , He Jianhang , Meng Yue , Li Haining
Published: January 2024

Aim：In this study, we thoroughly examine and discuss the clinical features, laboratory findings, treatment, and recovery of 38 neurobrucellosis cases. Additionally, we provide insights into the most recent research advances in the field of neurobrucellosis.
Materials and methods：In this study, we collected general data, clinical characteristics, ancillary tests, and treatment plans of 38 cases of neurobrucellosis diagnosed and treated at the General Hospital of Ningxia Medical University from March 2012 to December 2022.
Results：Among the 38 cases, 25 were male, and 23 had a clear history of cattle and sheep exposure. The most common clinical manifestations were fever (81.58%) and headache (76.32%). Brucella agglutination test was positive in 37 patients, and 37 patients showed increased protein in the cerebrospinal fluid. All 38 patients had a complete blood routine, with 11 cases showing abnormal white blood cell counts. Among the 29 patients who underwent cranial magnetic resonance imaging, 12 showed abnormalities. There were no in-hospital deaths among the patients.
Conclusions：Neurobrucellosis exhibits diverse clinical manifestations and can be difficult to differentiate from tuberculous meningitis. Routine tests such as complete blood routine and cranial magnetic resonance imaging have limited diagnostic value for neurobrucellosis and are prone to clinical misdiagnosis and underdiagnosis. Patients with a history of contact with cattle and sheep in nearby grazing areas and presenting with symptoms such as fever and headache should undergo laboratory tests such as Brucella agglutination test or cerebrospinal fluid culture to establish an early and accurate diagnosis. Prompt initiation of treatment with doxycycline, rifampin, and ceftriaxone sodium triple therapy against Brucellosis is crucial in areas close to pastoral regions with potential cattle and sheep exposure.
Decoding Heterogeneity in Data-Driven Self-Monitoring Adherence Trajectories in Digital Lifestyle Interventions for Weight Loss: A Qualitative Study
Authors: Li Shiyu , Du Yan , Meireles Christiane , Song Dan , Sharma Kumar , Yin Zenong , Brimhall Bradley , Wang Jing
Published: January 2024

Background: Data-driven trajectory modeling is a promising approach for identifying meaningful participant subgroups with various self-monitoring (SM) responses in digital lifestyle interventions. However, there is limited research investigating factors that underlie different subgroups. This qualitative study aimed to investigate factors contributing to participant subgroups with distinct SM trajectory in a digital lifestyle intervention over 6 months.
Methods: Data were collected from a subset of participants (n = 20) in a 6-month digital lifestyle intervention. Participants were classified into Lower SM Group (n = 10) or a Higher SM (n = 10) subgroup based on their SM adherence trajectories over 6 months. Qualitative data were obtained from semi-structured interviews conducted at 3 months. Data were thematically analyzed using a constant comparative approach.
Results: Participants were middle-aged (52.9 ± 10.2 years), mostly female (65%), and of Hispanic ethnicity (55%). Four major themes with emerged from the thematic analysis: Acceptance towards SM Technologies, Perceived SM Benefits, Perceived SM Barriers, and Responses When Facing SM Barriers. Participants across both subgroups perceived SM as positive feedback, aiding in diet and physical activity behavior changes. Both groups cited individual and technical barriers to SM, including forgetfulness, the burdensome SM process, and inaccuracy. The Higher SM Group displayed positive problem-solving skills that helped them overcome the SM barriers. In contrast, some in the Lower SM Group felt discouraged from SM. Both subgroups found diet SM particularly challenging, especially due to technical issues such as the inaccurate food database, the time-consuming food entry process in the Fitbit app.
Conclusions: This study complements findings from our previous quantitative research, which used data-drive trajectory modeling approach to identify distinct participant subgroups in a digital lifestyle based on individuals’ 6-month SM adherence trajectories. Our results highlight the potential of enhancing action planning problem solving skills to improve SM adherence in the Lower SM Group. Our findings also emphasize the necessity of addressing the technical issues associated with current diet SM approaches. Overall, findings from our study may inform the development of practical SM improvement strategies in future digital lifestyle interventions.
Trial registration: The study was pre-registered at ClinicalTrials.gov (NCT05071287) on April 30, 2022.
Active curling of epithelial monolayers dominated by actin cytoskeleton mechanics
Authors: Xu Guang-Kui , Wang Huan , Hang Jiu-Tao
Published: January 2024

Active curling of epithelial tissues, as an indispensable component of developmental morphogenesis, occurs frequently in both vivo and vitro microenvironments. Deciphering the mechanisms underlying the active curling of epithelial monolayers is crucial for understanding many physiological and pathological processes. Here, a multiscale structure-based cell monolayer model and an active constitutive relation are established to characterize this spontaneous curling of the epithelial tissue. It is shown that the asymmetric distribution of Myosin II along the apicobasal axis generates an active moment that drives spontaneous curling of the suspended epithelial tissue. The time-dependent deflection and rotation angle of the active curling are analytically solved, proving that the curling is driven by the active bending moment directly associated with the apicobasal asymmetric contractile force. Moreover, we demonstrate that the rotation angle is proportional to the apicobasal force ratio and inversely proportional to the thickness of epithelial tissues. In addition, we derive an approximate analytical relation between the out-of-plane curling behavior and in-plane stress, highlighting the significant influence of in-plane strain on curling behavior through the active bending moment. This study provides a pathway to elucidate the mechanical mechanism underlying complex morphological development as well as the physiological and pathological phenomena of epithelial tissues.
A novel PANoptosis-related lncRNA model for forecasting prognosis and therapeutic response in hepatocellular carcinoma
Authors: Lan Chenlu , Qin Haifei , Huang Zaida , Huang Xinlei , Peng Kai , Li Yuhua , Qin Chongjiu , Wei Yongguang , Zhou Xin , Liao Xiwen , Zhu Guangzhi , Peng Tao
Published: January 2024

Some studies have shown PANoptosis-related genes were related to the prognosis for hepatocellular carcinoma (HCC), but efforts for PANoptosis-related lncRNAs are scarce. Data of The Cancer Genome Atlas (TCGA) was used to identify prognostic PANoptosis-related lncRNAs, risk model and nomogram were constructed for predicting the prognosis of HCC. The clinical characteristic, mutation landscape, immune response, drug sensitivity, enriched biological process and pathway between low and high risk groups were analyzed. The Polymerase Chain Reaction (PCR) was performed to verify the expression of lncRNAs. Risk models displayed good predictive performance in TCGA, train and test cohorts with the area under the receiver operator characteristic curves (AUC) of 1- and 3- year OS > 0.7. Notably, the performance of nomogram and risk model was better than TNM stage (AUC: 0.717 and 0.673 vs 0.660). The risk group was proved to be an independent prognostic factor (p < 0.05). Furthermore, we found that patients of high risk group had a larger tumor size, higher AFP level and advanced TNM stage than the low group (p < 0.05). The functional enrichment analysis suggested that high risk group was related to the upregulated molecular characteristics of cell division, cell proliferation, cell cycle and p53 signaling pathway, and downregulated in metabolic pathway. The mutation analysis revealed an obvious difference of TP53 and CTNNB1 mutation between high and low risk groups. Immune response and drug sensitivity analysis discovered that high risk group was likely to benefit from immunotherapy and some molecular targeted drugs. In conclusion, the PANoptosis-related lncRNA model may be used to predict the prognosis and therapeutic response for HCC.