bluuebunny/crossref_metadata_2025 huggingface dataset:
Bhutanese Primary Science Teachers’ Epistemic Beliefs of Science
Authors: Dorji Karma , Namgyel Thinley
Published: October 2024

Epistemic beliefs of science (EBS) are considered to have a strong influence on how science teachers view science itself and carry out science teaching. To this end, Bhutanese primary science teachers, as much as secondary science teachers, are expected to possess sophisticated EBS. While this is one of the aims of the Bhutanese science education system, there is little to no information regarding Bhutanese primary science teachers’ EBS. Hence, this cross-sectional study examined EBS held by primary science teachers from three districts in Bhutan. One hundred and ninety-five (N = 195) primary science teachers took part in the study using a total population sampling design. Data collected using the Epistemic Beliefs of Science Questionnaire (EBSQ) were analysed using descriptive and inferential statistical methods. Findings revealed that Bhutanese primary science teachers from three districts in Bhutan held naive EBS in several aspects of source, certainty, development, and justification dimensions of scientific knowledge. The chi-square test of independence (χ2) revealed that there were no significant relationships between Bhutanese primary science teachers’ EBS and their teaching background (p > .05). The one-way analysis of variance (one-way ANOVA), while showed significant differences in certainty dimension, revealed that were no significant differences among Bhutanese primary science teachers’ EBS in other dimensions based on their academic qualifications (p > .05). The implications of research findings to the Ministry of Education, science curriculum documents, and teacher preparation are discussed.
Socioeconomic Disparities in Family Well-Being, Family Communication Quality, and Personal Happiness among Chinese: Findings from Repeated Cross-Sectional Studies in 2016–2023
Authors: Sze Katherine Y.P. , Ho Sai Yin , Lai Agnes Yuen Kwan , Sit Shirley Man Man , Lam Tai Hing , Wang Man Ping
Published: October 2024

Significant socioeconomic changes in Hong Kong have coincided with a conspicuous knowledge gap regarding the impact of disparities on family well-being, family communication quality, and personal happiness. To examine changes on family well-being, family communication quality, and personal happiness before, during, and after the 2019 social unrest and the COVID-19 pandemic in Hong Kong. Five repeated territory-wide cross-sectional surveys were conducted from 2016 to 2023, using telephone and online surveys on 27,074 adults in Hong Kong. Respondents rated their family health, happiness, harmony (family 3Hs), family communication quality, and personal happiness on scales of 0–10. Family well-being was the sum of family 3Hs divided by three (0–10). Trends by socioeconomic factors were analysed using linear prediction and multiple linear regression, weighted for sex and age. Highest scores for all outcomes were observed in 2016 and 2017, followed by a noticeable decline in 2020 and 2021, with the lowest scores recorded in 2023 except for personal happiness with its lowest score recorded in 2021. The decline since 2021 was most noticeable with low monthly household income (predicted margins in 2023 ranged from 5.55 to 6.46 for ≤ HK$19,999; 5.62 to 6.51 for HK$20,000–39,999; 5.81 to 6.78 for ≥ HK$40,000), but no differences were observed by education level. Female, older age, and higher monthly household income were significantly associated with higher family well-being, family communication quality, and personal happiness (all P < 0.001). Higher education level was only significantly associated with personal happiness (P = 0.008). We have first shown socioeconomic disparities in the declining family well-being, family communication quality, and personal happiness from 2016 to 2023 in Hong Kong. These alarming findings require targeted interventions and policies aimed at addressing these disparities and improving wellbeing in the population.
Stress Corrosion Cracking of Manganese Bronze in Water
Authors: Manz Olaf , Kral Milo
Published: October 2024

Continuous and centrifugal cast manganese bronze parts (C86300) experienced intergranular cracking in as few as 24 h after being stored outside. C-ring tests according to ASTM G38 were conducted to assess the material’s susceptibility to stress corrosion cracking (SCC) susceptibility and found that water was the most likely agent. The failure mechanism has been identified as intergranular SCC due to a combination of residual stress from a rough machining operation and water from rain or dew. To prevent cracking, a stress relief heat treatment immediately after the rough machining operation is recommended.
How global spine sagittal alignment and spinal degeneration affect locomotive syndrome risk in the elderly
Authors: Khasawneh Ramada R. , Abu-El-Rub Ejlal , Almazari Rawan. A. , Mustafa Ayman G.
Published: October 2024

Background

The aim of this study was to delineate the features of the locomotive syndrome (LS) risk stage in the elderly population, encompassing global spine sagittal alignment, visible spinal degenerative changes on plain radiographs, muscle strength, physical capabilities, and low back pain (LBP).

Methods

The study enrolled 232 subjects, evaluated using plain radiographs. The evaluation included measurements of lumbar lordosis (LLA), thoracic kyphosis (TKA), spinal inclination (SIA) angles, and sagittal vertical axis. Assessments included lumbar osteophyte formation (LOF) and lumbar disc height (LDH) to examine spinal degenerative changes. LS evaluation used the locomotive syndrome risk test based on LS risk criteria, classifying participants into no risk, stage 1 LS, and stage 2 LS groups. Using a visual analogue scale (VAS), we investigated the prevalence of low back pain (LBP) and assessed physical performances across these groups.

Results

There were 132 participants with no LS risk, 71 with stage 1 LS risk, and 29 with stage 2 LS risk. As LS risk increased, LBP prevalence and VAS scores rose, physical abilities, and back muscle strength decreased. TKA showed no variation across groups, while LLA decreased with advancing LS risk stage. Except for L1–L2 and L5–S1, lumbar disc height (LDH) decreased with higher LS risk stages. LOF occurrence increased notably with higher LS risk stages. Spinal inclination angle (SIA) significantly increased with advancing LS risk stages.

Conclusion

Participants diagnosed with LS exhibited an increased incidence of spinal degeneration, reduced LLA, and global spinal imbalance characterized by anterior spinal inclination.
The Role of Transurethral BPH Surgeries in Management of Urinary Symptoms in Prostate Cancer Patients, Narrative Review
Authors: Elsaqa Mohamed , El Tayeb Marawan M.
Published: October 2024

Purpose of Review

Prostate cancer and benign prostate hyperplasia (BPH) are two ubiquitous pathologies that may coexist. A significant percentage of patients with different stages of prostate cancer suffer lower urinary tract symptoms (LUTS) due to associated BPH. We aimed to review the literature regarding the role of transurethral surgeries in the management of prostate cancer patients and the different available management options.

Recent Findings

The evidence in literature for the use of BPH surgeries in prostate cancer patients is based mainly on low-quality retrospective studies. In patients on active surveillance, BPH surgeries are beneficial in relieving LUTS without oncological risk and can eliminate the contribution of adenoma to PSA level. In patients with advanced prostate cancer, palliative BPH surgery can relieve LUTS and urinary retention with unclear oncological impact; however some reports depict that the need for BPH surgery in advanced prostate cancer is associated with poorer prognosis. In patients receiving radiotherapy, various studies showed that transurethral resection of prostate (TURP) is associated with increased radiotoxicity despite some recent reports encouraging the use of Holmium Laser Enucleation of the Prostate (HoLEP) to improve urinary symptom scores before radiotherapy. The most commonly reported techniques utilized are TURP, photoselective vaporization of prostate (PVP) and HoLEP.

The use of BPH surgery is justified for relieving LUTS in selected prostate cancer patients on active surveillance or in advanced stages, however the use in the pre-radiotherapy settings remains controversial. Future prospective and randomized controlled trials are required for validating the benefits and assessing potential hazards.
Racial and Ethnic Differences in Patient Presentation and Treatments in Head and Neck Dermatofibrosarcoma Protuberans
Authors: Patel Aman M. , Desai Amar D. , Revercomb Lucy , Behbahani Sara , Filimonov Andrey
Published: October 2024

Head and neck dermatofibrosarcoma protuberans (HNDFSP) is a rare neoplasm with a high rate of local infiltration and local recurrence but a low rate of distant metastasis. Given the limited literature on HNDFSP and existing studies pointing to possible racial and ethnic differences, further research is needed to understand important clinical correlates that may impact treatment and prognosis. The National Cancer Database (NCDB) was queried for all cases of HNDFSP diagnosed from 2004 to 2016. Demographic characteristics of the included patients were compared using chi-squared and t-tests. Kaplan-Meier and Cox multivariable regression analyses were performed to assess survival differences. Of the 778 included patients, 526 (67.6%) patients were white, 113 (14.5%) were black, 33 (4.2%) were Asian, 87 (11.2%) were Hispanic, and 19 (2.4%) were classified as Other. White patients presented at a significantly older age (43.8 years) than did black (38.9 years) and Hispanic patients (37.9 years) (p = 0.02). White patients with HNDFSP had significantly higher income status (p = 0.0001), were more likely to be insured (p = 0.0001), and were more likely to have a high school diploma (p = 0.0001). There were no significant racial differences in 5-year (96.1%) or 10-year (92.0%) overall survival. None of the variables yielded a statistically significant value in Cox analysis. Differences exist in HNDFSP presentation between racial groups. Specifically, differences in income, insurance status, education level, and age of presentation exist between these groups. Future studies focused on morbidity are needed to better understand the consequences of these difference on HNDFSP patients.
Bootstrapping Concepts via Hybridization: A Step-by-step Guide
Authors: De Benedetto Matteo , Poth Nina
Published: October 2024

Carey’s (2009) account of bootstrapping in developmental psychology has been criticized out of a lack of theoretical precision and because of its alleged circularity (Rips et al. 2013, Cognition 128 (3): 320–330; Fodor 2010, Times Literary Supplement, 7–8; Rey 2014, Mind & Language 29 (2): 109–132). In this paper, we respond to these criticisms by connecting the debate on bootstrapping with recent accounts of conceptual creativity in philosophy of science. Specifically, we build on Nersessian’s (2010) hybrid-models-based theory of scientific conceptual change to develop a refined model of bootstrapping. The key explanatory feature of this model, which we will call hybrid bootstrapping, is the iterated hybridization of different representational domains. We show how hybrid bootstrapping can answer two major critiques that have been leveled against Carey’s account: the circularity challenge and the specification challenge.
Peer-to-peer training among health care professionals working in dialysis clinics: an education approach from the GoodRENal project
Authors: Avesani Carla Maria , García-Testal Alicia , Mesa-Gresa Patricia , Marin Alexandra-Elena , Van Craenenbroeck Amaryllis H. , Kouidi Evangelia , Clyne Naomi , Segura-Ortí Eva
Published: October 2024

Background

Lifestyle interventions aiming to improve dietary habits, increase physical activity level, and improve emotional well-being can positively impact clinical outcomes in patients with chronic kidney disease (CKD). Educational material for health care professionals working with CKD patients that focuses on why and how to promote lifestyle changes is lacking. The present study aims to depict the material and dissemination methods for the peer-to-peer training program developed for health care professionals working in the dialysis clinics of the four countries engaged in the GoodRENal project: Spain, Greece, Sweden, and Belgium.

Methods

This is an ERASMUS + project funded by the European Union (number 2020–1-ES01-KA2014-083141, http://goodrenal.eu/) named GoodRENal. The educational material was developed in English by a multidisciplinary team integrating the GoodRENal project (dietitian, physiotherapist, psychologist, and nephrologist). The material was then translated to Greek, Spanish, Swedish and Dutch and is available for download at the GoodRENal webpage (https://goodrenal.es/results-3/). After training, the health care professionals filled in an anonymous questionnaire regarding their degree of satisfaction with the training.

Results

In total, 138 health care professionals in the four dialysis clinics joined the peer-to-peer training, representing 50% to 92% of the health care professionals in each clinic. From the total sample, 78 health care professionals responded to the satisfaction questionnaire. The answers showed that most participants were very satisfied or satisfied with the peer-to-peer training and that they found this approach useful in their clinical practice.

Conclusion

The educational material developed for health care professionals working with patients on hemodialysis (HD) obtained good satisfaction scores from the participants.

Graphical Abstract
Modulating the Rhizosphere Medium and Indole − 3−butyric Acid Supply Influence Rooting, Nutrients and Biochemical Constituents and Histological Features of Pedilanthus tithymaloids
Authors: Abass Mohamed M. M. , Thabet Ramez S. , Lasheen Fawzy F. , Abdelhamid Ahmed N. , Hassan Karim M. , Saudy Hani Saber , Boghdady Mohammed S.
Published: October 2024

Pedilanthus tithymaloids is a popular temperate indoor succulent ornamental plant and is highly marketable. However, the appropriate propagation techniques should be adopted to solve the rooting issues of cuttings. Therefore, the present research was designed to specify the optimal indole − 3−butyric acid (IBA) concentration and rooting medium type for obtaining good rooting and healthy plants. Three IBA levels (0, 1.0, 2.0, and 3.0 g L− 1) and five growing mediums (sand, sand: clay, sand: peat moss, sand: perlite, and sand: vermiculite as 1:1, v/v) were used. The experiment was performed in a randomized complete block design in three replications. The obtained data illustrated that roots number per cutting and rooting percentage reached the maximum values by treating P. tithymaloids cuttings with 3.0 g L− 1 IBA x sand: perlite or sand: vermiculite medium. Cultivating the treated-IBA 3.0 g L− 1 cuttings of P. tithymaloids in sand: perlite showed the most enhancements in plant height, branches number and leaves number, leaf area and herb dry weight. However, the heaviest root dry weight was noticed with IBA 3.0 g L− 1 x sand: peat moss medium. Except sand medium, all other tested media in combination with IBA at 1.0, 2.0–3.0 g L− 1 showed remarkable stimulation effect on chlorophyll content. Sand: vermiculite mixture x IBA at 2.0 g L− 1 was the effective practice for improving carbohydrates percentage. By studying the anatomical changes of the adventitious root of P. tithymaloids plant, it was found that there was an increase in the root diameter, phloem and xylem tissues and xylem vessels diameter due to growing in sand: perlite x 3.0 g L− 1 IBA. In conclusion, dipping the cuttings bases of P. tithymaloids in 3.0 g L− 1 IBA and cultivation in sand: perlite considered the most effective combination practice for better rooting ability and growth and could be advisable for commercial production.
PopBERT. Detecting Populism and Its Host Ideologies in the German Bundestag
Authors: Erhard Lukas , Hanke Sara , Remer Uwe , Falenska Agnieszka , Heiberger Raphael Heiko
Published: October 2024

The rise of populism concerns many political scientists and practitioners, yet the detection of its underlying language remains fragmentary. This paper aims to provide a reliable, valid, and scalable approach to measure populist rhetoric. For that purpose, we created an annotated dataset based on parliamentary speeches of the German Bundestag (2013–2021). Following the ideational definition of populism, we label moralizing references to “the virtuous people” or “the corrupt elite” as core dimensions of populist language. To identify, in addition, how the thin ideology of populism is “thickened,” we annotate how populist statements are attached to left-wing or right-wing host ideologies. We then train a transformer-based model (PopBERT) as a multilabel classifier to detect and quantify each dimension. A battery of validation checks reveals that the model has a strong predictive accuracy, provides high qualitative face validity, matches party rankings of expert surveys, and detects out-of-sample text snippets correctly. PopBERT enables dynamic analyses of how German-speaking politicians and parties use populist language as a strategic device. Furthermore, the annotator-level data may also be applied in cross-domain applications or to develop related classifiers.
Undernutrition levels in Scottish older-adult population: a secondary data analysis of the Scottish Health Survey 2021
Authors: Morecroft D. , Crabtree D. R. , Johnstone A. M.
Published: October 2024

The proportion of the UK population over 65 years old is predicted to increase from 18.7% to 26% by 2066(1). However, healthy life expectancy (HLE) and disability free life expectancy (DLE) are decreasing(2, 3), which is particularly concerning in Scotland which also has the lowest overall life expectancy(4). Diet is a major modifiable factor in healthy aging(5) and should be a target to address declining HLE and DLE, but nutrient deficiencies in over 65s in Scotland are poorly understood. This study aimed to understand the presence and extent of inadequate intake of protein, fibre, vitamins, and minerals within over 60 year olds in Scotland.

Secondary data analysis of the Scottish Health Survey 2021(6) was performed. Dietary data of older adults (≥ 60 years old, n = 1344) were analysed for protein, fibre, and micronutrient (from food sources) inadequacies, defined as percentage below estimated average requirement, reference nutrient intake or adequate intake(7, 8). Wald Z-test was used to analyse inadequacy between males and females, and urban and rural populations. Differences between Scottish index of multiple deprivation (SIMD) levels (1 [most deprived] to 5 [least deprived]) were analysed using χ2 test and cellwise sub-analysis(9) with Bonferroni corrections.

The percentage of over 60s that had inadequate nutrient intake was highest for vitamin D (97%), fibre (93%), selenium (90%), potassium (79%) and Zinc (65%). Compared to males, females were at a greater risk of undernutrition in 18 of the 25 nutrients analysed, of which 11 were significant (p<0.05). Compared to rural populations, urban populations were at a greater risk of undernutrition in 22 of 25 nutrients analysed, of which 10 were significant. People in SIMD 1 were at a greater risk of undernutrition in 20 of 25 nutrients analysed, of which 14 were significant. 40% of over 60s had inadequate protein intake. Risk of inadequate protein intake was greatest for people in SIMD 1 (56%, p<0.001). 24% of over 60s had inadequate folate intake which was significantly higher in females than males (28% and 18%, respectively; p<.001), urban than rural (26% and 19%, respectively; p<.01), and in SIMD1 (36%; p<.001). Inadequate fibre intake was significantly higher in females than males (95% and 91% respectively, p<.01), and urban than rural (95% and 89%, respectively, p<.001). 26% of over 60s had inadequate calcium intake. Inadequate calcium intake was significantly higher in females than males (25% and 17%, respectively; p<.001).

These data highlight a considerable undernutrition risk, both overall and within specific nutrients important for healthy aging, in Scotland’s older adult population. Those in SIMD 1, females, and urban dwelling demographics being particularly vulnerable. Although the extent of potential health implications, are dependent on key aspects such as nutrient absorption and utilisation.
Exploring frailty perspectives of older people and professionals: a systematic integrative review
Authors: Golbach Rianne D.J. , Bunt Steven , Jager-Wittenaar Harriët , Finnema Evelyn J. , Hobbelen Johannes S.M.
Published: October 2024

Frailty is a common but complex phenomenon that is approached from theoretical and professional perspectives but rarely from the perspectives of older people and their essential stakeholders. Different or opposing perspectives on frailty at personal, organisational, and community levels can negatively affect care for frail older people. This systematic integrative review synthesises the perspectives on frailty of older people, health/social care professionals, informal caregivers, managers and policymakers, using thematic analysis. We use the Joanna Briggs Institute–Critical Appraisal Checklist to appraise the quality of 52 qualitative and mixed-method studies drawn from the PubMed/MEDLINE, CINAHL, PsycINFO, Embase, and Web of Science databases (inception–December 2023). Of these, 33 include the perspectives of older people, 27 of health/social care professionals, four of managers, and six of informal caregivers. Structuring the perspectives along six themes – ‘the multi-dimensional nature of frailty’, ‘the dynamics of frailty’, ‘the complexity of frailty’, ‘frailty in relation to age’, ‘frailty in relation to health’ and ‘frailty in relation to dependence’ – revealed substantive similarities in the conceptualisation of frailty between older people and professionals, e.g. regarding frailty’s dynamic and multi-dimensional nature. However, older people and professionals differ in their interpretations of frailty: older people take a personal view, while professionals take a more practical view. The identified discrepancies in perspectives may affect care relationships and care for frail older people. Therefore, we advocate a systems approach that incorporates multiple perspectives to form a comprehensive view of frailty and allows for a situation-specific shared understanding of frailty in older people.
A Responsibility to Support Civilian Resistance Movements? Broadening the Scope of Nonviolent Atrocity Prevention
Authors: Staunton Eglantine , Jacob Cecilia
Published: October 2024

In recent years, there has been an upsurge in the number of civilian resistance movements (CRMs) within states to counter government repression and coups d’états through which civilians are on the frontlines of state brutality and mass atrocities. This article considers the implications of CRMs for atrocity prevention and the associated responsibility to protect norm by asking, Should the international community support CRMs as part of its wider commitment to ending mass atrocities? In this article, we evaluate both military and nonmilitary support to CRMs. We argue that in the context of coups and government repression, providing lethal military support to CRMs will often make things worse in terms of atrocity prevention. We however explain that the provision by the international community of nonlethal and nonmilitary support through political recognition, technical assistance, and accountability can yield positive results. We illustrate this argument with the case of Myanmar.
The Cost of Atrocity: Strategic Implications of Russian Battlefield Misconduct in Ukraine
Authors: Renic Neil
Published: October 2024

Since commencing its illegal invasion in 2022, the Russian military and authorities have committed numerous war crimes against the people of Ukraine. These include the mutilation and execution of combatants; the torture, kidnapping, forced expulsion, rape, and massacre of civilians; and indiscriminate attacks on densely populated areas. In this essay, I evaluate the strategic implications of this misconduct, focusing exclusively on Western responses. I argue that war crimes can and often do negatively impact the strategic goals of the perpetrator, but whether and how this occurs is rarely governed exclusively by the offending action. Western perceptions of battlefield atrocity, shaped as they are by identity, race, and politics, may radically shift from one context to another. In the case of the Russia-Ukraine war, the status of both the participants and the conflict itself has helped inculcate a particular sensitivity among Western actors to the battlefield criminality of Russia. Drawing on evidence from the 2022 Bucha massacre and the ongoing bombing of Ukrainian civilians, I argue that Russian misconduct has consolidated Western support for the Ukrainian military effort, politically, diplomatically, and materially.
Returning the War to Russia: Drones and Discrimination in the Defense of Ukraine
Authors: Enemark Christian
Published: October 2024

This essay assesses the morality of Ukraine's use of drones to attack targets inside Russia. Following its invasion by Russian forces, Ukraine has had a just cause to wage a war of self-defense. However, its efforts to achieve that cause remain subject to moral limits. Even a state that has been unjustly attacked may not, for example, respond by deliberately targeting the attacking state's civilian population. To do so would violate the jus in bello principle of discrimination. The essay first describes how drone technology has frequently enabled long-range strikes against Russian military assets as well as other targets inside cities. It then explains why it would be morally wrong for Ukraine to attack its enemy's population centers. First, Russian civilians are not liable to attack, and this nonliability is undiminished by the injustice of Russia's invasion or by any in bello wrongs committed by the Russian military. Second, attacking Russian cities with drones would arguably achieve little or no self-defensive benefit for Ukraine, and it could even be counterproductive.
Technology and the Civilianization of Warfare
Authors: Peperkamp Lonneke
Published: October 2024

The Russia-Ukraine war demonstrates the crucial role of technology in modern warfare. The use of digital networks, information infrastructure, space technology, and artificial intelligence has distinct military advantages, but raises challenges as well. This essay focuses on the way it exacerbates a rather familiar challenge: the “civilianization of warfare.” Today's high-technology warfare lowers the threshold for civilian participation in the war effort. A notable example is the widespread use of smartphone apps by Ukrainian civilians, who thereby help the armed forces defend against Russian aggression. Through the lenses of international humanitarian law, conventional just war theory, and revisionist just war theory, this essay evaluates the normative dimensions of such civilian participation. The analysis shows that civilians can lose their legal protections when they use these apps to directly participate in hostilities, and this loss of immunity can be justified by Michael Walzer's conventional just war theory. Revisionism, however, puts the justness of the war at the forefront, and so sheds doubt on the moral liability of Ukrainian civilians. Considering the broader implications, including the blurring combatant-civilian distinction, indicates that such civilianization of warfare should not be welcomed; the risks will often outweigh the benefits. At a minimum, states ought to exercise restraint in mobilizing civilians and inform them of the implications of their actions.
Chagos in the South Pacific? The principle of self-determination and the France-Vanuatu dispute over the Matthew and Hunter Islands
Authors: Giraudeau Géraldine , Song Lili , Mosses Morsen
Published: October 2024

The dispute over the Matthew and Hunter Islands (MHIs) has long been a constant strain on Vanuatu-French relations. The article examines this dispute in light of the Chagos Advisory Opinion and a few other cases concerning territorial disputes. It first submits that sovereignty over the MHIs had never been raised until 1962, when, at the occasion of a private claim, France and Britain, the two administering powers of the New Hebrides at that time, considered the issue. The two states reached an agreement in 1965, asserting that the MHIs were part of the French colony of New Caledonia and not the British-French Condominium of the New Hebrides. This article then considers the legal implications and lawfulness of the agreement, which did not take into account the local populations’ will. Although there are some important differences between the Chagos and MHIs disputes, mainly due to the fact that the MHIs are uninhabited, the applicability of the right of self-determination to both cases is nevertheless beyond doubt. The article contends therefore that the 1965 Agreement between France and Britain may constitute a violation of the right to self-determination of the people of the New Hebrides (Vanuatu), who were not consulted on the decision to attach the MHIs to the French territory of New Caledonia, and suggests that there may be, however, some other legal principles under international law that can come into play. Finally, the article contends that negotiated solutions could be a potential way forward for the parties involved.
AL-FĀRĀBĪ’S EIGHTH FALLACY EXTRA DICTIONEM AND AVERROES’ CRITICISM
Authors: Lamprakis Alexander
Published: October 2024

This paper aims to introduce and discuss al-Fārābī's (d. 950–1 CE) fallacy from transfer and substitution in his little-studied “On Deceptive Topoi” (Kitāb al-amkina al-muġalliṭa) and the criticism leveled at him by Averroes (d. 1198 CE) for violating Aristotle's claim of the exhaustiveness of his list of fallacies. The first and larger half of this paper introduces al-Fārābī's treatise and its innovations upon Aristotle's Sophistici elenchi. The second half focuses on Averroes’ criticism in his so-called middle commentary (talḫīṣ) on Aristotle's SE and discusses the validity of his arguments against al-Fārābī. As the final analysis will show, Averroes’ criticism does not sufficiently take into account the independence of al-Fārābī's treatise from Aristotle's SE, its disregard for the study of dialectical deception and counter-deception, and its particular focus on the demonstrative sciences. In light of al-Fārābī's innovation his “On Deceptive Topoi” turns out to be a work of great originality drawing on a broad range of source texts.
Pyu urns, Indian calendars, and Myanmar culture
Authors: Frasch Tilman
Published: October 2024

The article addresses the important question of the calendar used in dating the Payagyi Pyu urns from Sri Ksetra (mod. Pyay) in Myanmar. It shows that, of the four calendars used in Myanmar at the time, two—the Ajjagona and Buddhist eras—can be ruled out. This leaves the Saka and Myanmar eras as the only possible options. However, although the Saka era was used for dating Indian records up to East Bengal, it was only used twice for dating an inscription in central Myanmar and, in addition, the early dates on the Payagyi urns seem to preclude its use in Myanmar that early on. The article concludes therefore that, for dating the Pyu urns, most likely the Pyu–Myanmar calendar of 638 CE was used.
The effects of district magnitude on the number of intra-party factions: the case of Colombia, 1958–1990
Authors: Campos-Herrera Germán , Navia Patricio
Published: October 2024

The study of party systems tends to focus on individual parties and overlooks factions and other sub-party units. Although the impact of the district magnitude on the number of electoral parties is well established, the electoral rules incentives on party subunits have been overlooked. Using electoral results at the district level, we assess the effect of the district magnitude on the effective number of parties and effective number of factions competing in elections and with legislative seats in Colombia (1958–1990). By focusing on parties and factions, we produce empirical evidence from 444 datapoints to support the claim made elsewhere that roots of multi-partism were present throughout the period studied, including under the National Front (1958–1970), where only two parties were permitted. The district magnitude impacts the number of parties and the number of party subunits, but its effect is stronger on the former. When the National Front came to an end and electoral rules were modified in the 1970s, there was an increase in party factionalism and new parties in the years before multiparty system rules were enshrined in the 1991 constitution.
Towards planetary health systems: a manifesto for a revised quadruple aim for healthcare improvement
Authors: Perilli Alessio , Adduci Andrea , Ricciardi Walter , de Belvis Antonio Giulio , Cadeddu Chiara
Published: October 2024

Non-technical summary

Healthcare systems significantly impact the environment, which in turn affects human health. To address this, we propose to revise a popular framework for healthcare improvement, by introducing the advancement of planetary health (the health of both humans and the natural systems) among the aims that health systems should pursue. This approach suggests reducing medical service needs through disease prevention, minimizing environmental impacts, and supporting global efforts to protect planetary health. Practical applications to bring about these pathways are documented in the literature.

Technical summary

Restoring the health of the planet, with concurrent benefits for human civilization, is paramount. Healthcare systems play a crucial role in this regard, considering the environmental impact of health services. Widely recognized approaches to designing healthcare systems for the optimization of their performance are based on the pursuit of multiple aims, such as the Triple Aim and Quadruple Aim frameworks. The objective of this work is to revise the latter by substituting ‘Advance Planetary Health’ for ‘Improve Population Health’.

The objective of advancing planetary health supports all other pre-existing objectives: lowering costs, enhancing patient experience, team wellbeing, and population health, which directly relates to planetary health. Health systems promoting planetary health reduce the need for medical services through disease prevention and health promotion, pursue the provision of appropriate care, minimize the overall environmental impact of medical services, and support planetary health initiatives across all sectors and society. Multiple interconnected pathways exist to operationalize the above components.

A revised quadruple aim for healthcare improvement, aligned with social and economic goals of sustainable prosperity and wellbeing, may be a desirable step toward constructing planetary health systems capable of maximizing the health of humans and natural systems.

Social media summary

It's time for new ‘planetary health systems’: focusing on planetary health to enhance healthcare performance. #PlanetaryHealth #ClimateCrisis #HealthcareImprovement.
Sensitivity of two corn hybrids to tolpyralate plus reactive oxygen species–generating herbicides
Authors: Soltani Nader , Shropshire Christy , Fluttert John , Sikkema Peter H.
Published: October 2024

Herbicides that inhibit 4-hydroxyphenylpyruvate dioxygenase (HPPD) can be mixed with herbicides that generate reactive oxygen species (ROS) to enhance the spectrum, level, speed, and consistency of weed control efficacy; however, mixtures of these herbicides can increase corn injury. A total of five field trials were conducted from 2021 to 2023 in Ridgetown, Ontario, to determine the sensitivity of two corn hybrids (‘DKC39-97’ and ‘B79N56PWE’) to tolpyralate plus ROS-generating herbicides (atrazine, bromoxynil, bentazon, or glufosinate) applied postemergence at the recommended rate (1×) and sequentially to represent a spray overlap (2×) in the field. Tolpyralate plus atrazine, bromoxynil, bentazon, or glufosinate (2× rates) caused greater corn injury to DKC39-97 than B79N56PWE corn at 1, 2, and 4 wk after treatment (WAT). Tolpyralate plus atrazine, bromoxynil, bentazon, or glufosinate (2× rates) caused 38%, 36%, 29%, and 18% injury to DKC39-97 corn, but only 5%, 20%, 9%, and 2% injury to B79N56PWE corn, respectively at 1 WAT. Corn injury to both hybrids decreased over time with ≤2% injury at 8 WAT. Tolpyralate + atrazine, bromoxynil, or bentazon (2× rates) caused a 17%, 16%, and 13% height reduction, respectively, of DKC39-97 corn at 2 WAT; however, tolpyralate + glufosinate did not reduce DKC39-97 corn height. Tolpyralate + bromoxynil or bentazon (2× rates) caused a 12% and 10% height reduction of B79N56PWE corn, respectively, at 2 WAT; however, tolpyralate + atrazine or glufosinate did not reduce B79N56PWE corn height. Tolpyralate + atrazine or glufosinate (2× rates) caused a greater corn height reduction of DKC39-97 corn than B79N56PWE corn at 2 WAT. Grain yield was on average 2% lower from DKC39-97 than B79N56PWE corn. Tolpyralate + bromoxynil or bentazon (2× rates) caused 7% and 6% corn grain yield reduction compared to tolpyralate plus glufosinate (2× rate). Results indicate that tolpyralate + ROS-generating herbicides can cause corn injury, which is influenced by corn hybrid and ROS-generating herbicide. Corn producers need to consider the differential sensitivity of corn hybrids and ROS-generating herbicides when using an HPPD-inhibiting herbicide for weed management.
Coastal Dune Erosion and Slumping Processes in the Swash‐Dune Collision Regime Based on Field Measurements
Authors: van Wiechen P. P. J. , Mieras R. , Tissier M. F. S. , de Vries S.
Published: October 2024

This paper studies hydrodynamic and morphodynamic field measurements of two storms with dune erosion in the swash‐dune collision regime. It analyses (a) the behavior and change of the total dune profile over the course of both storms (b) the erosion rate at the dune base, (c) the slumping frequency, and (d) the volumes of individual slumps. The erosion rate at the dune base shows a strong positive correlation with the square of the total water levels that were exceeded for 2% of the time, recorded approximately 5–6 m in front of the dune face (r = 0.91). Individual slumping events occurred when nearly all sediments from previous slumps at the dune base were transported away from the dune. A strong positive correlation was found between the time between two consecutive slumps, and the volume of the first slump divided by the mean erosion rate between the two slumps (r = 0.90). As a consequence, smaller slumps were followed more rapidly by a new slump than larger slumps, under identical erosion rates. The majority of the slumping events occurred after the last wave impact before a slumping event, when the instantaneous water level in front of the dune was still retreating. No clear process based on the incident hydrodynamics could be identified that determined the size of individual slumps. Overall, the results of this study suggest that the morphodynamic behavior of the upper dune face and dune crest is primarily steered by the erosion at the dune base.
BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial
Authors: Torr Bethany , Jones Christopher , Kavanaugh Grace , Hamill Monica , Allen Sophie , Choi Subin , Garrett Alice , Valganon-Petrizan Mikel , MacMahon Suzanne , Yuan Lina , Way Rosalind , Harder Helena , Gold Rochelle , Taylor Amy , Gabe Rhian , Lucassen Anneke , Manchanda Ranjit , Fallowfield Lesley , Jenkins Valerie , Gandhi Ashu , Evans D. Gareth , George Angela , Hubank Michael , Kemp Zoe , Bremner Stephen , Turnbull Clare
Published: October 2024

Background

Genetic testing to identify germline high-risk pathogenic variants in breast cancer susceptibility genes is increasingly part of the breast cancer diagnostic pathway. Novel patient-centred pathways may offer opportunity to expand capacity and reduce turnaround time.

Methods

We recruited 1140 women with unselected breast cancer to undergo germline genetic testing through the BRCA-DIRECT pathway (which includes a digital platform, postal saliva sampling and a genetic counsellor telephone helpline). Ahead of consenting to the test, participants were randomised to receive information about genetic testing digitally (569/1140, 49.9%) or via a pre-test genetic counselling consultation (571/1140, 50.1%).

Results

1001 (87.8%) participants progressed to receive their pre-test information and consented to testing. The primary outcome, uptake of genetic testing, was higher amongst participants randomised to receive digital information compared with those randomised to a pre-test genetic counselling consultation (90.8% (95% CI: 88.5% to 93.1%) vs 84.7% (95% CI: 81.8% to 87.6%), p = 0.002, adjusted for participant age and site). Non-inferiority was observed in relation to patient knowledge, anxiety, and satisfaction.

Conclusions

Findings demonstrate that standardised, digital information offers a non-inferior alternative to conventional genetic counselling, and an end-to-end patient-centred, digital pathway (supported by genetic counselling hotline) could feasibly be implemented into breast oncology settings.

Clinical trial registration

The study is registered with, and protocol available on, ClinicalTrials.gov (NCT04842799).
Defining the complex needs of families with rare diseases—the example of telomere biology disorders
Authors: Wilsnack Catherine , Rising Camella J. , Pearce Emily E. , Forbes Shepherd Rowan , Thompson Ashley S. , Majid Alina , Werner-Lin Allison , Savage Sharon A. , Hutson Sadie P.
Published: October 2024

Families with rare diseases, such as telomere biology disorders (TBDs), may have extensive unmet needs given the heterogeneity, chronicity, and potential severity of illness. TBDs are rare inherited syndromes associated with high risk of bone marrow failure, cancer, pulmonary fibrosis, and other severe, chronic complications. To identify gaps in clinical care, we aimed to ascertain the perceived unmet needs of adults and family caregivers, current or bereaved, of individuals with TBDs. Participants were aged ≥18 years with a self-reported TBD diagnosis and/or ever caregivers to one or more family members with a TBD. Participants completed an online survey (N = 35) and/or an audio-recorded telephone interview (N = 32). We calculated descriptive statistics in SPSS and thematically analyzed interview transcripts. Quantitative and qualitative data were analyzed concurrently. Most participants were aged ≥35 years, female, highly educated, and medically insured. Survey respondents reported numerous unmet needs in psychosocial, medical, financial, and daily activity domains. In interviews, participant descriptions validated and contextualized the salience of these unmet needs. Both qualitative and quantitative data identified critical shortfalls in addressing chronic family distress and specialty care coordination. Adults and caregivers of individuals with TBDs have a high risk of adverse psychosocial sequelae given extensive unmet needs. These findings provide a foundation for understanding the range and extent of gaps in care for families with rare diseases, especially TBDs but that are likely applicable to others. Tailored multi-disciplinary interventions involving patients, families, clinicians, researchers, and patient advocacy communities are required to appropriately address care needs for all rare diseases.
Designing chemical systems for precision deuteration of medicinal building blocks
Authors: Dabbs Jonathan D. , Taylor Caleb C. , Holdren Martin S. , Brewster Sarah E. , Quillin Brian T. , Meng Alvin Q. , Dickie Diane A. , Pate Brooks H. , Harman W. Dean
Published: October 2024

Methods are lacking that can prepare deuterium-enriched building blocks, in the full range of deuterium substitution patterns at the isotopic purity levels demanded by pharmaceutical use. To that end, this work explores the regio- and stereoselective deuteration of tetrahydropyridine (THP), which is an attractive target for study due to the wide prevalence of piperidines in drugs. A series of d0–d8 tetrahydropyridine isotopomers were synthesized by the stepwise treatment of a tungsten-complexed pyridinium salt with H−/D− and H+/D+. The resulting decomplexed THP isotopomers and isotopologues were analyzed via molecular rotational resonance (MRR) spectroscopy, a highly sensitive technique that distinguishes isotopomers and isotopologues by their unique moments of inertia. In order to demonstrate the medicinal relevance of this approach, eight unique deuterated isotopologues of erythro-methylphenidate were also prepared.
The genetic landscape of basal ganglia and implications for common brain disorders
Authors: Bahrami Shahram , Nordengen Kaja , Rokicki Jaroslav , Shadrin Alexey A. , Rahman Zillur , Smeland Olav B. , Jaholkowski Piotr P. , Parker Nadine , Parekh Pravesh , O’Connell Kevin S. , Elvsåshagen Torbjørn , Toft Mathias , Djurovic Srdjan , Dale Anders M. , Westlye Lars T. , Kaufmann Tobias , Andreassen Ole A.
Published: October 2024

The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans. Our multivariate GWAS identified 72 genetic loci associated with basal ganglia volumes with a replication rate of 55.6% at P < 0.05 and 87.5% showed the same direction, revealing a distributed genetic architecture across basal ganglia structures. Of these, 50 loci were novel, including exonic regions of APOE, NBR1 and HLAA. We examined the genetic overlap between basal ganglia volumes and several neurological and psychiatric disorders. The strongest genetic overlap was between basal ganglia and Parkinson’s disease, as supported by robust LD-score regression-based genetic correlations. Mendelian randomization indicated genetic liability to larger striatal volume as potentially causal for Parkinson’s disease, in addition to a suggestive causal effect of greater genetic liability to Alzheimer’s disease on smaller accumbens. Functional analyses implicated neurogenesis, neuron differentiation and development in basal ganglia volumes. These results enhance our understanding of the genetic architecture and molecular associations of basal ganglia structure and their role in brain disorders.
Glucosinolate structural diversity shapes recruitment of a metabolic network of leaf-associated bacteria
Authors: Unger Kerstin , Raza Syed Ali Komail , Mayer Teresa , Reichelt Michael , Stuttmann Johannes , Hielscher Annika , Wittstock Ute , Gershenzon Jonathan , Agler Matthew T.
Published: October 2024

Host defenses can have broader ecological roles, but how they shape natural microbiome recruitment is poorly understood. Aliphatic glucosinolates (GLSs) are secondary defense metabolites in Brassicaceae plant leaves. Their genetically defined structure shapes interactions with pests in Arabidopsis thaliana leaves, and here we find that it also shapes bacterial recruitment. In model genotype Col-0, GLSs (mostly 4-methylsulfinylbutyl-GLS) have no clear effect on natural leaf bacterial recruitment. In a genotype from a wild population, however, GLSs (mostly allyl-GLS) enrich specific taxa, mostly Comamonadaceae and Oxalobacteraceae. Consistently, Comamonadaceae are also enriched in wild A. thaliana, and Oxalobacteraceae are enriched from wild plants on allyl-GLS as carbon source, but not on 4-methylsulfinylbutyl-GLS. Recruitment differences between GLS structures most likely arise from bacterial myrosinase specificity. Community recruitment is then defined by metabolic cross-feeding among bacteria. The link of genetically defined metabolites to recruitment could lead to new strategies to shape plant microbiome balance.