bluuebunny/crossref_metadata_2025 huggingface dataset:
DRH1, a p68-related RNA helicase gene, is required for chromosome breakage in Tetrahymena
Authors: McDaniel Stephen L. , Zweifel Erica , Harris Peter K. W. , Yao Meng-Chao , Cole Eric S. , Chalker Douglas L.
Published: October 2016

The p68 DEAD box helicases comprise a widely conserved protein family involved in a large range of biological processes including transcription, splicing and translation. The genome of the ciliate Tetrahymena thermophile encodes two p68-like helicases, Drh1p and Lia2p. We show that DRH1 is essential for growth and completion of development. In growing cells, Drh1p is excluded from the nucleus and accumulates near cortical basal bodies. In contrast, during sexual reproduction, this protein localizes to meiotic micronuclei, initially in punctate foci in regions where centromeres and telomeres are known to reside and later in post-zygotic differentiating somatic macronuclei. Differentiation of the macronuclear genome involves extensive DNA rearrangements including fragmentation of the five pairs of germline-derived chromosomes into 180 chromosomal sub-fragments that are stabilized by de novo telomere deletion. In addition, thousands of internal eliminated sequences (IESs) are excised from loci dispersed throughout the genome. Strains with DRH1 deleted from the germline nuclei, which do not express the protein during post-zygotic development, fail to fragment the developing macronuclear chromosomes. IES excision still occurs in the absence of DRH1 zygotic expression; thus, Drh1p is the first protein found to be specifically required for chromosome breakage but not DNA elimination.
Deregulated expression of HDAC9 in B-cells promotes development of lymphoproliferative disease and lymphoma
Authors: Gil V. S. , Bhagat G. , Howell L. , Zhang J. , Kim C. H. , Stengel S. , Vega F. , Zelent A. , Petrie K.
Published: October 2016

Histone Deacetylase 9 (HDAC9) is expressed in B-cells and its overexpression has been observed in B-lymphoproliferative disorders and B-cell non-Hodgkin lymphomas (B-NHL). We examined HDAC9 protein expression and copy number alterations in primary B-NHL samples, identifying high HDAC9 expression among various lymphoma entities and HDAC9 copy number gains in 50% of diffuse large B-cell lymphoma (DLBCL). To study the role of HDAC9 in lymphomagenesis we generated a genetically engineered mouse (GEM) model that constitutively expressed an HDAC9 transgene throughout B-cell development under the control of the immunoglobulin heavy chain (IgH) enhancer (Eμ). Here we report that the Eμ-HDAC9 GEM model developed splenic marginal zone lymphoma and lymphoproliferative disease (LPD) with progression towards aggressive DLBCL, with gene expression profiling supporting a germinal centre cell origin in common with human tumors. Analysis of Eμ-HDAC9 tumors suggested that HDAC9 may contribute to lymphomagenesis by altering pathways involved in growth and survival as well as modulating BCL6 activity and p53 tumor suppressor function. Epigenetic modifications play an important role in the germinal center response and deregulation of the B-cell epigenome as a consequence of mutations and other genomic aberrations are being increasingly recognized as important steps in the pathogenesis of a variety of B- cell lymphomas. A thorough mechanistic understanding of these alterations will inform the use of targeted therapies for these malignancies. These findings strongly suggest a role for HDAC9 in B-NHL and establish a novel GEM model for the study of lymphomagenesis and, potentially, pre-clinical testing of therapeutic approaches based on histone deacetylase inhibitors.
Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR
Authors: Liemburg-Apers Dania C. , Wagenaars Jori A. L. , Smeitink Jan A. M. , Willems Peter H. G. M. , Koopman Werner J. H.
Published: October 2016

Mitochondria play a central role in cellular energy production, and their dysfunction can trigger a compensatory increase in glycolytic flux to sustain cellular ATP levels. Here, we studied the mechanism of this homeostatic phenomenon in C2C12 myoblasts. Acute (30 min) mitoenergetic dysfunction induced by the mitochondrial inhibitors piericidin A and antimycin A stimulated Glut1-mediated glucose uptake without altering Glut1 (also known as SLC2A1) mRNA or plasma membrane levels. The serine/threonine liver kinase B1 (LKB1; also known as STK11) and AMP-activated protein kinase (AMPK) played a central role in this stimulation. In contrast, ataxia-telangiectasia mutated (ATM; a potential AMPK kinase) and hydroethidium (HEt)-oxidizing reactive oxygen species (ROS; increased in piericidin-A- and antimycin-A-treated cells) appeared not to be involved in the stimulation of glucose uptake. Treatment with mitochondrial inhibitors increased NAD+ and NADH levels (associated with a lower NAD+:NADH ratio) but did not affect the level of Glut1 acetylation. Stimulation of glucose uptake was greatly reduced by chemical inhibition of Sirt2 or mTOR–RAPTOR. We propose that mitochondrial dysfunction triggers LKB1-mediated AMPK activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR–RAPTOR and Glut1-mediated glucose uptake.
Evolution of ribozymes in the presence of a mineral surface
Authors: Stephenson James D. , Popović Milena , Bristow Thomas F. , Ditzler Mark A.
Published: October 2016

Mineral surfaces are often proposed as the sites of critical processes in the emergence of life. Clay minerals in particular are thought to play significant roles in the origin of life including polymerizing, concentrating, organizing, and protecting biopolymers. In these scenarios, the impact of minerals on biopolymer folding is expected to influence evolutionary processes. These processes include both the initial emergence of functional structures in the presence of the mineral and the subsequent transition away from the mineral-associated niche. The initial evolution of function depends upon the number and distribution of sequences capable of functioning in the presence of the mineral, and the transition to new environments depends upon the overlap between sequences that evolve on the mineral surface and sequences that can perform the same functions in the mineral's absence. To examine these processes, we evolved self-cleaving ribozymes in vitro in the presence or absence of Na-saturated montmorillonite clay mineral particles. Starting from a shared population of random sequences, RNA populations were evolved in parallel, along separate evolutionary trajectories. Comparative sequence analysis and activity assays show that the impact of this clay mineral on functional structure selection was minimal; it neither prevented common structures from emerging, nor did it promote the emergence of new structures. This suggests that montmorillonite does not improve RNA's ability to evolve functional structures; however, it also suggests that RNAs that do evolve in contact with montmorillonite retain the same structures in mineral-free environments, potentially facilitating an evolutionary transition away from a mineral-associated niche.
Quebrando Paradigmas en Contextos Presidencialistas: un Examen sobre la Capacidad Legislativa en Chile
Authors: Toro Maureira Sergio , Acevedo de la Harpe Carolina , Matamala Rosales Kimberling
Published: November 2016

La presente nota de investigación busca dar cuenta sobre el desarrollo del trabajo legislativo en Chile durante el periodo post-autoritario. Se sostiene que si bien el país cuenta con una institucionalidad que entrega fuertes poderes al Presidente, en la práctica el proceso de generación de políticas se ha hecho a través de estructuras de negociación y coordinación que han fortalecido la función de los partidos en el Congreso. A través de un resumen de resultados sobre el trabajo legislativo y la teoría existente, se demuestra que los procesos de formación de la ley han mantenido una dinámica estable y sin mayores conflictos entre poderes.
Cargos de confiança, partidos políticos e burocracia federal
Authors: Lopes Felix , Praça Sérgio
Published: November 2016

O artigo analisa alguns critérios relevantes que são acionados por partidos e parlamentares para a divisão e ocupação dos cargos federais de livre nomeação. Enfatizamos aspectos atinentes ao processo de seleção dos nomes e critérios de divisão dos cargos, apontando que a) a influência partidária na ocupação dos cargos varia por áreas de governo; b) o líder partidário ou da bancada é o principal responsável por receber e processar as demandas políticas por cargos, encaminhando-as à negociação com a Casa Civil; c) alguns de cargos, tais como os responsáveis por ordenar despesas nos órgãos e os que detém capacidade regulatória mais cobiçados politicamente; d) critérios regionais – que talvez seja a métrica explicativa da facção, é indispensável para dar inteligibilidade à gestão presidencial da coalizão, pois ordena grande parte da divisão de poder intra e interpartidária; e) a ocupação de cargos políticos nas estatais são cruciais para entender o xadrez da divisão de poder entre partidos na administração federal; f) que o processo de verticalização das nomeações em que um só partido define os nomes para todos os cargos politicamente relevantes é um evento raro e sugere a importância de novas estratégias para avaliar a associação entre divisão de pastas ministeriais e apoio legislativo, principalmente considerando a importância também do item e. A análise se baseia em dados coletados por meio de 45 entrevistas em profundidade realizadas com membros da alta burocracia federal: secretários-executivos, membros da Casa Civil e líderes de partidos da coalizão, nos governos Cardoso, Lula e Rousseff.
The Changing Role of Ministers in the Legislative Agenda in Brazil
Authors: Rennó Lúcio , Wojcik Stefan
Published: November 2016

Who, within the Cabinet, participates in elaborating the government’s legislative agenda, and why? How has the role of ministers in elaborating the legislative agenda changed over time? In this paper, we discuss the structure of legislative bill cosponsorship networks among cabinet members in Brazil. Are ministers serious participants in the elaboration of the agenda, sharing its authorship with colleagues from their and other parties in the coalition? We develop a theory of cabinet members’ participation in the formulation of the government’s legislative agenda in the Brazilian Congress. Using descriptive statistics and network-analytic techniques, we reveal continuity and change in the role of ministers in the legislative agenda over time.
Nomenclatural history of the generic name Haplocladium (Bryophyta: Leskeaceae)
Authors: Ochyra Ryszard , Garland Mark
Published: November 2016

The nomenclatural history of the moss generic name Haplocladium is discussed. Originally, this name was validly published in 1879 by Karl Müller of Halle as a subsection, Hypnum subsect. Haplocladium. It gained generic status in 1897 when the same author provided a brief diagnosis of the new genus Haplocladium. Under Art. 41.4 Haplocladium is treated as a name at a new rank published without reference to the presumably intended basionym Hypnum subsect. Haplocladium. It is shown that the authorship of Haplocladium microphyllum, which was previously attributed to "(Hedw.) Broth.", should correctly be ascribed to "(Hedw.) Müll.Hal." (in Hedwigia 36: 140. Jun 1897). The confusion associated with H. gracile is clarified and the authorship of this name is correctly attributed to "(Schimp.) Müll.Hal." (in Hedwigia 36: 140. Jun 1897).
Report of the Nomenclature Committee for Vascular Plants: 68
Authors: Applequist Wendy L.
Published: November 2016

The following seven generic names are recommended for conservation: Anisomeles against Epimeridi, Goodallia Benth. against Goodallia T.E. Bowdich, Leysera against Asteropterus, Limniris against Pseudo-iris, Palhinhaea against Lepidotis, Razumovskia against Razoumofskya, and Volutaria against Amberboi. The following eleven species names are recommended for conservation: Allium saxatile M. Bieb., non Pall., with a conserved type, Carex leersii F.W. Schultz, nom. cons., against C. cuprina, Cereus adscendens against C. platygonus, Chirita hamosa with a conserved type, Clethra alnifolia with a conserved type, Cuscuta campestris against C. gymnocarpa, Eucalyptus rossii with a conserved type, Hemionitis plantaginea Cav., non Sm., Orobanche foetida with a conserved type, Senecio sarracenicus with a conserved type, and Sisymbrium pumilum Stephan, non Lam. The following five species names are not recommended for conservation: Acacia multipinnata Ducke against A. multipinnata Willd., Calamus laevigatus against C. plicatus, Dianthus crassipes against D. ferrugineus, Ophrys subfusca with a conserved type (because it is believed to be unnecessary), and Paullinia thalictrifolia against P. bipinnata. The following eleven species names are recommended for rejection: Anavinga ovata, Cestrum subsessile, Myosotis collina, Rosa ferruginea, Solanum ambrosiacum, Solanum coronatum, Solanum diantherum, Solanum jubeba, Solanum multiangulatum, Solanum perianthomega, and Trichomanes adiantoides. Cupressus tortulosa is not recommended for rejection because it is believed to be an orthographic variant of C. torulosa. It is not recommended that the conserved place of publication of Lecythidaceae be changed. It is recommended that Habenaria rodriguesii Cogn. and H. rodriguezii R. González & Lizb. Hern. be treated as homonyms. It is recommended that Bonannia and Bonania, Petteria and Peteria, and Ceropegia oculata and C. occulta be treated as not being homonyms. It is recommended that Agave gustaviana be treated as validly published. It is recommended that "Alonsoa intermedia G. Lodd.", "Caladium lividum G. Lodd.", "Cerbera laurifolia G. Lodd.", "Dichorisandra picta G. Lodd.", "Govenia Lindl. ex G. Lodd.", "Govenia superba G. Lodd.", "Hedychium flavescens G. Lodd.", and "Maxillaria galeata Lindl. ex G. Lodd." be treated as not validly published. After two ballots, no vote of at least 11 either for or against has been obtained for proposals to reject Dianthus hungaricus or to conserve Salsola with a conserved type, Tweedia with a conserved type, Calandrinia grandiflora against C. glauca, Cliffortia filicaulis with a conserved type, Leucostegia immersa against Davallia truncata, Maackia hupehensis against M. chinensis, or Tamarix ramosissima against T. pentandra, or for a request to treat Hoppea Willd. and Hoppia Nees as homonyms.
Origin of the Rapa endemic genus Apostates: Revisiting major disjunctions and evolutionary conservatism in the Bahia alliance (Compositae: Bahieae)
Authors: Baldwin Bruce G. , Wood Kenneth R.
Published: November 2016

Molecular phylogenetic analyses of nuclear and chloroplast DNA sequences indicate that the rediscovered Apostates, known only from Rapa in the Austral Islands of southeastern Polynesia, represents an example of extreme long‐distance dispersal (>6500 km) from southwestern North America and one of at least four disjunctions of comparable magnitude in the primarily New World Bahia alliance (tribe Bahieae). Each of the disjunctions appears to have resulted from north‐to‐south dispersal since the mid‐Miocene; three are associated with such marked morphological and ecological change that some of the southern taxa (including Apostates) have been treated in distinct genera of uncertain relationship. Phyllotaxy within the Bahia alliance, however, evidently has been even more conservative evolutionarily than reflected by previous taxonomies, with alternate‐leaved and opposite‐leaved clades in Bahia sensu Ellison each encompassing representatives of other genera that share the same leaf arrangements. A revised taxonomic treatment of the Bahia alliance is proposed to recognize morphologically distinctive, monophyletic genera, including the critically endangered Apostates.
University midwifery societies: Support for student midwives, by student midwives
Authors: Power Alison , Grzelak Ilaria
Published: November 2016

Student midwives usually begin their programme of study feeling motivated and optimistic, but there is evidence to suggest the stressors of the programme are too much for some students, leading to attrition. Given the current shortage of midwives, additional strategies are required to support student midwives to successfully complete their studies and join the workforce. Student-led societies within universities can offer a support system. A student midwife at the University of Northampton, Ilaria Grzelak, realised that ‘traditional’ student societies would not meet the specific needs of student midwives, whose course involves not only academic demands but also the challenges of clinical practice. She decided to set up a society specifically for midwifery students, which continues to benefit her fellow student midwives.
Patella fractures in cats with persistent deciduous teeth — Knees and Teeth Syndrome (KaTS)
Authors: Langley-Hobbs Sorrel
Published: November 2016

Most patellar fractures are seen in young female and male cats aged between 1–3 years. Many affected cats have a history of persistent or retained deciduous teeth, and in some cats their permanent teeth also do not erupt properly. The patellar fractures are usually unilateral at first presentation but become bilateral within 3–9 months. Pin and tension band wire fixation is associated with a high complication rate and often results in further fragmentation of the patella. A technique that does not involve inserting an implant into the sclerotic patella, such as circumferential wiring, tension band without a pin, or a tibial quadriceps repair may be beneficial, but conservative treatment can yield equally good results and is inevitably associated with a lower complication rate. Further work is needed before definitive statements can be made regarding the best treatment for this condition, as there are too low numbers or too many variables in the published retrospective studies. Many affected cats will fracture other bones as they age. An underlying bone or connective tissue disease is suspected in cats with patellar fractures and persistent deciduous teeth, and for ease of discussion and case recruitment the disease has been termed knees and teeth syndrome or KaTS.
Three twenty-first-century disaster films, the ideology of science and the future of democratic debate
Authors: Maeseele Pieter , Van Der Steen Laurens
Published: November 2016

While news media representations of science and technology have received ample attention in academic research, there is a lack of comparable research into disaster films. Drawing on an in-depth qualitative content analysis, this article aims to explore the representation of science in three recent disaster films: The Day After Tomorrow (Emmerich, 2004), Contagion (Soderbergh, 2011) and Rise of the Planet of the Apes (Wyatt, 2011). We find these films’ representation of science contributing to a reification of science and the promotion of the ‘ideology of science’. We conclude by discussing how this representation potentially shapes the context in which late modern risks are approached in social and political debates, and to what extent this might contribute to facilitating or impeding democratic debate and citizenship.
Citizenship and the economic crisis in Europe: An introduction
Authors: Hoskins Bryony , Kerr David , Liu Liyuan
Published: November 2016

This article analyses the changing nature of Active and Participatory Citizenship in Europe during the period of the financial crisis from 2008–2015 and introduces the special issue which has a focus on this topic. This article and the accompanying special issue shed light on the current critical situation in Europe, how we got here and provides critical insights on where we may be headed. The findings of the research show that during the period of the economic crisis the European Union (EU) was seen to take a leadership role championing austerity and neoliberal economic policies whilst many of its citizens suffered and began to lose trust in the EU, its institutions and leaders. National politicians often successfully shifted blame to the EU for domestic policies that made citizens and public services suffer in the name of austerity for recovery. At the same time, Active and Participatory Citizenship policies received major cuts to funding, as part of the austerity drive, and were no longer considered a policy priority at both the European and the national level as concerns about mounting unemployment and a skills crisis took over. In addition, there was a general policy shift from cosmopolitan European Citizenship to a more nationalistic and, reactive citizenship driven by responses to pressing social issues such as extremism, radicalisation, migration and violence. The article concludes that in order to maintain the European project the Active and Participatory agenda needs to urgently be restored to give people a sense of belonging and ownership of Europe.
Salud y Anarquía desde Dowlais: The translocal experience of Spanish anarchists in South Wales, 1900–15
Authors: Yeoman James Michael
Published: November 2016

In the early twentieth century a group of Spanish anarchists settled in the town of Dowlais, South Wales, as part of a wider migration to the area prompted by the town’s ironworks. Over the following fifteen years this community kept in constant contact with their comrades in Spain through the networks sustained by the anarchist press. Examination of these records reveals the dislocation experienced by these migrants, and their efforts to retain their identity and standing within the movement they had left behind. This study highlights the benefits of a translocal approach towards anarchist internationalism, which focuses on the experience of ordinary members of the movement and their struggles to overcome the challenges presented by international movement.
Delegitimization accelerated: Democracy, accountability and the Troika experience in Cyprus
Authors: Katsourides Yiannos
Published: November 2016

This article examines the impact of the economic crisis on the Cypriot political and party systems (2008–15). While not solely the result of the economic crisis, the entire political system is experiencing a severe legitimacy crisis: levels of trust in political institutions are low and falling and voters today are very sceptical of political parties. Despite these feelings, though, most Cypriots have decided to exit the political system altogether rather than change their mode and form of participation. Therefore, social and political protest remains minimum and symbolic. All evidence seem to suggest a process of citizen disengagement from politics is taking place: however, while the citizens disengage the party system still exhibits signs of endurance. Nonetheless, on closer examination, changes are materializing at both the individual and the group level. The emerging volatility and increased fragmentation of the political space means there are forces and individuals within society that are not politically or otherwise aligned and/or represented in the political sphere, thus creating niche markets for new entrepreneurs.
Music listening in the twenty-first century: Italian consumer attitudes to Internet radio
Authors: Colapinto Cinzia , Manzi Giancarlo
Published: November 2016

The Internet has both dismantled the music system and addressed its inequalities. Audio as a platform is stronger than ever as more and more ways to listen continue to emerge. The popularity of radio, whether via digital streaming, satellite or traditional AM/FM, is linked to consumer tendency to multitask. This study seeks to highlight the changes taking place using an exploratory methodology, examining listeners’ behaviour, effects and corporate reactions in Italy. Our exploratory analysis of Italian radio listeners indicates that Internet music listening is the real catalyst for change in the music industry, while interactive features nevertheless play a minor role.
Book Reviews
Authors: Killmeier Matthew , Luscombe Anya
Published: November 2016

LISTEN IN TERROR: BRITISH HORROR RADIO FROM THE ADVENT OF BROADCASTING TO THE DIGITAL AGE, RICHARD J. HAND (2014) Manchester: Manchester University Press, 232 pp., ISBN: 9780719081484, h/bk, £75.00

THE FIRST LADY OF RADIO: ELEANOR ROOSEVELT’S HISTORIC BROADCASTS, STEPHEN D. SMITH (ED.) (2014) New York and London: The New Press, 272 pp., ISBN-10: 1620970422, h/bk, $25.95
Los sonidos del ’45
Authors: Corrado Omar
Published: November 2016

Se estudia el papel de las expresiones sono- ras en la vida política de Buenos Aires en el  período comprendido entre los acontecimien- tos que fueron definiendo el fin de la Segunda  Guerra Mundial y los años iniciales del pero- nismo (1944-1946). El repertorio incluye des- de las rimas circunstanciales a composiciones  escritas según las tradiciones académicas; de  repertorios patrióticos, partidarios o «clásicos»  sedimentados a músicas populares recientes  difundidas por la industria discográfica, con la  generación de nuevos textos para canciones  preexistentes como procedimiento más exten- dido de producción. Se lo contextualiza en el  marco de las manifestaciones, actos de cam- paña, proclamaciones, conmemoraciones par- tidarias, funerales, festejos, emisiones radia- les que puntuaron la vida política del período.  Se concluye sobre la funcionalidad de estas  expresiones en la consolidación de sensibilida- des grupales, ideológicas y partidarias.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PEMANFAATAN PELAYANAN KESEHATAN DI WILAYAH KERJA PUSKESMAS TAMBARANA KECAMATAN POSO PESISIR UTARA KABUPATEN POSO
Authors: Napirah Muh Ryman , Rahman Abd , Tony Agustina
Published: October 2016

Community Health Center is a health service facility that organizes public health efforts and the efforts of individual health at the first level, with more prioritizes promotive and preventive efforts, to achieve the highest public health status in its working area. Utilization of Community Health Center service is influenced by several factors like the public perception of health, public perception of the quality of service, family income and level of education. This study aimed to determine the relationship of the public perception of health, public perception of the quality of service, family income and education level with Health Service Utilization in the working area of Community Health Center Tambarana North Coastal of Poso sub-district, Poso district. This type of research was analytical survey research with cross sectional approach. The total of the sample were 69 respondents which was drawn by using Standley Lameshow formula which the population was known. Data was analyzed descriptively which was known as univariate and bivariate analysis, on the credibility degree of 95% (p <0.05). Chi Square test results showed that the public perception of health related to health service utilization (ρ = 0.000), public perception of the quality of service was not related to health service utilization (ρ = 0.213), family income relatedto health service utilization (ρ = 0.004), and there was a relationship between the education level with health service utilization (ρ = 0.000). The relation absence of public perception of service quality with health service utilizationmay be affected by physical evidence, reliability, responsiveness, assurance and empathy.
IDENTIFIKASI PENCEMAR WADUK MANGGAR KOTA BALIKPAPAN
Authors: Rezagama Arya , Tamlikha Ahmad
Published: October 2016

Waduk Manggar terletak di Kelurahan Karangjoang Kecamatan Balikpapan Utara merupakan sumber air baku utama sebesar  900  liter/detik. Status mutu air waduk tahun 2013 menunjukkan kondisi tercemar Berat (Badan Lingkungan Hidup, 2013). Kualitas air waduk terukur fluktuatif dimana terjadi penurunan kualitas air secara sesaat hingga baku mutu kelas 4. Untuk mengetahui faktor pencemaran Waduk diperlukan analisa sumber pecemar dan kemampuan daya tampung Waduk Manggar. Sumber pencemaran dapat bersifat alamiah maupun antropogenik. Penelitian menggunakan metode kuantitatif yang dikuatkan dengan analisa kualitatif. Perhitungan debit menggunakan metode pendekatan konversi curah hujan peanman, analisa daya tampung waduk menggunakan panduan PERMEN LH No. 28 Tahun 2009. Ketersediaan inlet debit kritis pada bulan agustus mencapi 2,8 m3/det. Sedangkan puncak musim kemarau terjadi pada bulan Agustus, September dan Oktober. Beban pencemaran dominan disebabkan oleh sumber alami tanah podsolik yang bersifat masam dan melarutkan kadar besi yang tinggi di batuan. Hal ini yang menyebabkan penurunan DO secara fluktuatif. Sedangkan beban pencemaran dari aktivitas manusia masih sangat kecil dibandingkan daya purifikasi waduk. Kualitas air waduk memiliki daya tampung yang masih baik dan tergolong kelas 1. Terdapat pengaruh yang signifikan dari kondisi tahun basa dan kering terhadap kualitas air. Pada musim basah, kualitas air waduk cenderung memiliki DO rendah, Fe yang tinggi.
EVALUASI PENYEDIAAN SARANA DAN PRASARANA DI PERUMAHAN PURI DINAR MAS SEMARANG
Authors: Adimagistra Tiasa , Pigawati Bitta
Published: October 2016

Community needs for settlement area, especially in the city of Semarang increase rapidly, so the government in 2005 make a program called 100,000 RSS (Simple Healthy House) to meet those needs. RSS is a settlement with facilities and infrastructure that are inadequate. The construction of facilities and infrastructure of the settlement should refer to the SNI 03-1733-2004 on Procedures for Environmental Planning in Urban Housing. The research objective is to evaluate the facilities and infrastructure based on ISO and user perception in Puri Dinar Mas Semarang. The method which used to analyze are the quantitative descriptive and comparative methods. The descriptive quantitative method is used to identify the availability and existing condition with the user's perception of the infrastructure Puri Dinar Mas, while the comparative descriptive method is used to compare the existing condition with SNI and comparing the user's perception of the condition of housing infrastructure based on the observation. There is a 61% infrastructure is available based on SNI and 70% in good condition. Based on the results of the comparison with SNI only 32% meet the standard. The results of the perception of users 80% are stated that the condition of facilities and infrastructure that exist in this housing is good, meanwhile the comparison of existing condition with the perception of users found that 84% is good, 8% is bad, and the remaining 8% is moderate.
KAPASITAS KELEMBAGAAN DALAM PENGEMBANGAN DESA WISATA (STUDI KASUS: DESA WISATA KETENGER, BANYUMAS)
Authors: Prafitri Gita Ratri , Damayanti Maya
Published: October 2016

Desa Wisata Ketenger is one of the oldest tourism village in Banyumas and has a lot of potential to be developed. According to Head of Youth, Sports, Culture and Touris Department in Banyumas, only two of six tourism villages in Banyumas is worth visit by tourists ie Desa Wisata Ketenger and Desa Wisata Dawuhan. It is influenced by the ability or capacity Pokdarwis as management of a tourism village in enhancing the knowledge and skills of the community through programs. The objective of this study is to determine the institutional capacity in development of Desa Wisata Ketenger. Capacity that will be researched include individual capacity and organizational capacity. The research was conducted using qualitative descriptive. Data were obtained through interviews and field observations. Results from this study indicate that in level of organization, organization has shown a good capacity in the aspect of external partnerships, aspects of tourism potential development, as well as aspects of tourism village promotion.Unfortunately, POKDARWIS "Ketenger Adventure" are less of ability to show a good capacity in leadership and coordination aspect, While at the individual level, there are good capacity in pioneering the development of tourism potential. Individuals have enough capacity in the management of tourist attractions, souvenir management, as well as service to the tourists. However, individuals have less capacity both in the understanding and application of the concept of integrated tourism village. To improve the ability at the level of individuals and organizations, Desa Wisata Ketenger have gained capacity building programs that held both of the Department of Tourism and besides offices.   
TRANSFORMASI PERUMAHAN SOSIAL DAN KEBERLANJUTAN PERUMAHAN DI PERUMNAS SENDANGMULYO
Authors: Yuliastuti Nany , Sukmawati Annisa Mu’awanah
Published: October 2016

Based on the reality on the ground with a variety of reasons and is, in a relatively short period has undergone a physical change by the wishes and needs of its owners. During its development, the house is not only seen from the quantitative aspect but also growing in terms of quality. In terms of its range tailored to the needs of, social, economic, institutional, as well as the development of the family concerned. Improved physical quality is usually directly proportional to the level of quality of life of its owner. In the framework of realization of self-actualization trigger, physical changes in the residential houses diverse forms/form and its range depends on the abilities, desires and needs of each family. The many activities uncontrolled housing physical development, particularly in the RS and related to the development and physical changes in the home that have an impact on environmental damage, so that its existence should receive special attention. This research takes object on the Housing  Perumnas Sendangmulyo. The research conduct on 83 households in the sample of 497 households inhabit the object of research. The research methodology used the quantitative methodology and to obtain necessary data and information of the variables, this studies using questionnaire, interviews, and observations. Analysis techniques in the proof of linkages between variables using the method of cross tabulation and chi-square analysis, double regression and contingency coefficient correlation. The final results of this study is the identification of the level of quality of housing transformation that occur in the housing in the Perumnas housing and can be concluded that there are a link and influences between quality of life by physical changes in existing homes. The quality of housing, it means is related economic and social. Level of housing transformations that house is basically influenced by the level of income, education, family size and motivation of the owners of the house, while the types of jobs tend to have no effect on the physical changes in housing.
Data, Data and Even More Data: Harvesting Insights From the Data Jungle
Authors: Skiera Bernd
Published: October 2016

Increasing global digitalization brings huge amounts of data. Finding a successful way to handle all this data and to transform it into real insights will be a critical success factor in the future. The biggest challenge for data science applications in marketing is that many marketing people studied marketing because they no longer wanted to do mathematics. A good marketing campaign will still have to be creative, touch emotions and build a brand, but more and more marketing managers will also need technical and analytical skills. It will more than ever be necessary to determine real causal effects to pull the right levers. Consumer insights have always been considered a major driver for growth, but in the digital world, successful growth can also come from improved technical and analytical implementation and skillful application of new tools and methods.
Marketing and Data Science: Together the Future is Ours
Authors: Chintagunta Pradeep , Hanssens Dominique M. , Hauser John R.
Published: October 2016

The synergistic use of computer science and marketing science techniques offers the best avenue for knowledge development and improved applications. A broad area of complementarity between the typical focus in statistics and computer science and that in marketing offers great potential. The former fields tend to focus on pattern recognition, control and prediction. Many marketing analyses embrace these directions, but also contribute by modeling structure and exploring causal relationships.
Marketing has successfully combined foci from management science with foci from psychology and economics. These fields complement each other because they enable a broad spectrum of scientific approaches. Combined, they provide both understanding and practical solutions to important and relevant managerial marketing problems, and marketing science is already very successful at obtaining unique insights from big data.
On Storks and Babies: Correlation, Causality and Field Experiments
Authors: Lambrecht Anja , Tucker Catherine E.
Published: October 2016

The explosion of available data has created much excitement among marketing practitioners about their ability to better understand the impact of marketing investments. Big data allows for detecting patterns and often it seems plausible to interpret them as causal. While it is quite obvious that storks do not bring babies, marketing relationships are usually less clear. Apparent “causalities” often fail to hold up under examination. If marketers want to be sure not to walk into a causality trap, they need to conduct field experiments to detect true causal relationships. In the present digital environment, experiments are easier than ever to execute. However, they need to be prepared and interpreted with great care in order to deliver meaningful and genuinely causal results that help improve marketing decisions.
Using Big Data for Online Advertising Without Wastage: Wishful Dream, Nightmare or Reality?
Authors: Grether Mark
Published: October 2016

Big data contains lots of information about consumers and allows companies real-time and data-assisted decision making to gain significant competitive advantages. Digital advertising is an important application for tailoring services to individual needs. Customized advertising is expected to be more effective, cost less, and better received by society. But what looks deceptively simple when it succeeds is frequently quite difficult to implement in practice. It is difficult to judge and validate the quality of automatically generated data. And besides quality, there are other aspects that make it tricky to determine the value of the data. A reasonable price for data depends on the context of its application and the potential cost savings it generates. And not only the price per impression is unclear. The number of contacts is also less obvious than it seems at first glance. Primarily third party data providers often incur problems with the monetization of big data and many are struggling to survive. They depend on the fairness of the data buyer and a successful business model has yet to be developed.
Data Analysis Trumps Specialist Advice: How Direct Banks Function
Authors: Skiera Bernd
Published: October 2016

Low interest rates and sluggish economic growth are not exactly ideal conditions for the financial services industry. Almost daily we are confronted with reports of inadequate capital bases, declining earnings, and layoffs at banks. But while many traditional retail banks are struggling with a business downturn, the direct bank market is enjoying steady and respectable growth despite a challenging environment. Dr. Schmidberger, Fully Authorized Representative at ING-DiBa Germany, offers us a glimpse behind the curtains of this direct bank. We will learn how data technology is used so that bank customers are (more) satisfied.
Counterpossibles and the nature of impossible worlds
Authors: Rasmussen Mattias Skipper
Published: November 2016

One well-known objection to the traditional Lewis-Stalnaker semantics of counterfactuals is that it delivers counterintuitive semantic verdicts for many counterpossibles (counterfactuals with necessarily false antecedents). To remedy this problem, several authors have proposed extending the set of possible worlds by
Microwave properties of natural rubber based composites containing carbon black-magnetite hybrid fillers
Authors: Al-Ghamdi Ahmed A. , Al-Hartomy Omar A. , Al-Solamy Falleh , Dishovsky Nikolay , Malinova Petrunka , Shtarkova Rossitsa
Published: November 2016

The paper presents the synthesis and characterization of a carbon black-magnetite hybrid filler. The complex study on the structure of the filler has shown the magnetite phase to be distributed both over the surface (inter-aggregately) and inside (intra-aggregately) the carbon black particles, thus forming a true hybrid material. The results from the investigations on the mechanical and microwave properties of natural rubber-based composites filled with the new hybrid filler have been also reported. They have been compared to those of a composite comprising the physical mixture of carbon black and magnetite (at the same ratio as in the hybrid filler). The determined microwave characteristics of the composite comprising the hybrid filler obtained reveal the possibility for its use in manufacturing elastomer-based microwave absorbers.
Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy
Authors: Benkafadar Nesrine , Menardo Julien , Bourien Jérôme , Nouvian Régis , François Florence , Decaudin Didier , Maiorano Domenico , Puel Jean‐Luc , Wang Jing
Published: October 2016

Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin‐induced ototoxicity remains unclear, and hearing preservation during cisplatin‐based chemotherapy in patients is lacking. We found activation of the ATM‐Chk2‐p53 pathway to be a major determinant of cisplatin ototoxicity. However, prevention of cisplatin‐induced ototoxicity is hampered by opposite effects of ATM activation upon sensory hair cells: promoting both outer hair cell death and inner hair cell survival. Encouragingly, however, genetic or pharmacological ablation of p53 substantially attenuated cochlear cell apoptosis, thus preserving hearing. Importantly, systemic administration of a p53 inhibitor in mice bearing patient‐derived triple‐negative breast cancer protected auditory function, without compromising the anti‐tumor efficacy of cisplatin. Altogether, these findings highlight a novel and effective strategy for hearing protection in cisplatin‐based chemotherapy.
Histone H4 Facilitates the Proteolysis of the Budding Yeast CENP-ACse4 Centromeric Histone Variant
Authors: Deyter Gary M R , Hildebrand Erica M , Barber Adrienne D , Biggins Sue
Published: October 2016

The incorporation of histone variants into nucleosomes can alter chromatin-based processes. CENP-A is the histone H3 variant found exclusively at centromeres that serves as an epigenetic mark for centromere identity and is required for kinetochore assembly. CENP-A mislocalization to ectopic sites appears to contribute to genomic instability, transcriptional misregulation, and tumorigenesis, so mechanisms exist to ensure its exclusive localization to centromeres. One conserved process is proteolysis, which is mediated by the Psh1 E3 ubiquitin ligase in Saccharomyces cerevisiae (budding yeast). To determine whether there are features of the CENP-A nucleosome that facilitate proteolysis, we performed a genetic screen to identify histone H4 residues that regulate CENP-ACse4 degradation. We found that H4-R36 is a key residue that promotes the interaction between CENP-ACse4 and Psh1. Consistent with this, CENP-ACse4 protein levels are stabilized in H4-R36A mutant cells and CENP-ACse4 is enriched in the euchromatin. We propose that the defects in CENP-ACse4 proteolysis may be related to changes in Psh1 localization, as Psh1 becomes enriched at some 3′ intergenic regions in H4-R36A mutant cells. Together, these data reveal a key residue in histone H4 that is important for efficient CENP-ACse4 degradation, likely by facilitating the interaction between Psh1 and CENP-ACse4.
VIENAS PIRMŲJŲ LOGIKOS NAGRINĖJIMŲ LOTYNŲ KALBA
Authors: Pabijutaitė Živilė
Published: November 2016

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NUODUGNŪS IR ORIGINALŪS LEVINAS TYRINĖJIMAI
Authors: Bertman Batsheva
Published: November 2016

Emmanuel Levinas: A Radical Thinker in the Time of Crisis, Edited by Rita Šerpytytė. Vilnius: Vilnius University Publishing House, 2015. 214 p. ISBN 978-609-459-671-1
TRENDS AND CHALLENGES OF BRAZILIAN PELLETS INDUSTRY ORIGINATED FROM AGROFORESTRY
Authors: Garcia Dorival Pinheiro , Caraschi José Cláudio , Ventorim Gustavo , Vieira Fabio Henrique Antunes
Published: October 2016

ABSTRACT Wood pellets are biofuels produced from agroforestry waste such as sugarcane bagasse, wood sawdust and shavings. They are compressed biofuels that have low moisture, allowing high combustion efficiency, especially because they are natural products of easily handling with high energy density. To explore pellets opportunities in Brazil (production and marketing), it is necessary to provide information about the chemical and energy characteristics, technologies, prices and prospects of this market. Thus, this article aims to organize and make this information available, enabling general knowledge on the subject and subsidize more investment in the biofuels sector; mostly by adding value to agroforestry waste, available in large volumes in this country. The results showed a young industry, with sixteen plants and production of 49.39 ktonnes of pellets in 2014, but using only 25.5% of its annual production capacity.
WOOD ANATOMY OF SEVEN SPECIES KNOWN AS "PAU-PARA-TUDO" IN BRAZIL
Authors: Leme Claúdia Luizon Dias
Published: October 2016

ABSTRACT Different medicinal plant species can be sold under the same common name. Considering the importance of the correct identification, this study aims to separate, using wood anatomy, seven species popularly known as pau-para-tudo. The results show that Drimys brasiliensis is separated from the others by the presence of tracheids. Capsicodendron dinisii hhas scalariform perforation plates and oil cells associated with the axial parenchyma. Axial parenchyma paratracheal vasicentric and in marginal bands beyond the rays' width, can separate Osteophoeum platyspermum from Simaba cedron. Handroanthus serratifolius has the unique presence of the axial unilateral paratracheal parenchyma and storied cell elements (parenchyma, fibers and vessel elements). Rauvolfia sellowii and Leptolobium dasycarpum can be separated by the number of square/upright marginal ray cells, greater in Rauvolfia sellowii. Thus, this work shows that wood anatomy is a valuable tool for species separation, helps with the identification and consequently is important for the quality control of plant product.
IMPACT OF TOPOGRAPHIC CORRECTION ON SOIL AND VEGETATION COVER SPECTRAL CHARACTERIZATION BY TM/LANDSAT 5 IMAGERY
Authors: Ponzoni Flávio Jorge
Published: October 2016

ABSTRACT Several topographic correction methods have been developed to be applied to orbital imagery. The main objective of these initiatives has been focused on improving land cover mapping. Despite of some discussions that include spectral approaches, no attention has been given to the impact of such correction on the spectral characterization of different targets. That impact can influence relationships commonly explored between radiometric data from orbital imagery and biophysical and/or geophysical parameters. TM/Landsat 5 images (orbit 218, row 76) from a mountainous region located between São Paulo, Minas Gerais and Rio de Janeiro states (Brazil) were converted to surface reflectance values. Two topographic correction methods considering different sampling strategies were applied. The local illumination was taking into account during the result analysis in order to evaluate the selective effect of the topographic correction on the spectral characterization of bare soils and vegetated surfaces. The results indicated that the sampling strategy influences both the visual aspect of the topographic corrected images and the spectral characterization of targets. Spectral distortions caused by the topographic correction procedures were higher at darker illumination conditions. The topographic correction is a procedure that deserves attention when exploring spectral characterization of different targets. Sometimes it contributes positively in qualitative approaches such as mapping or digital classification, but it can imply in severe influence on quantitative approaches that are dependent on the targets spectral characterization.