bluuebunny/crossref_metadata_2025 huggingface dataset:
Infusion from Opuntia ficus-indica Peels: The Effects of Drying and Steeping Conditions
Authors: Ferreira Ricardo M. , Wessel Dulcineia F. , Silva Artur M. S. , Saraiva Jorge A. , Cardoso Susana M.
Published: November 2023

The escalating production of processed prickly pear products has led to a substantial rise in waste materials, particularly peel, which is rich in bioactive chemicals and holds the potential for value-added product development. However, the high perishability of these peels imposes effective preservation techniques. So, this work aimed to explore the potential of prickly pear peels from O. ficus-indica ‘Rossa’, ‘Gialla’, and ‘Bianca’ cultivars for the production of Opuntia beverages, namely infusions. To achieve this goal, two distinct drying methods, namely microwave drying and a food dehydrator, were employed with the latter method, resulting in the higher recovery of phenolic compounds (0.5 mgGAE/mL vs. 0.16 mgGAE/mL) and the higher antioxidant capacity of the resulting infusions. Additionally, various steeping conditions involving water temperatures of 80, 90, and 100 °C were assessed to maximize the levels of phenolic compounds and antioxidant activity. The results demonstrate that the better overall drying method temperature and steeping conditions for the food dehydrator were at 35 °C and boiling water (100 °C) due to its generally better results and practicality. Sensorial trials revealed that the three infusions were generally accepted (score > 7.20 out of 9) but that O. ficus-indica ‘Rossa’ received the highest ratings. This study offers valuable insights for optimizing drying methods and steeping conditions to preserve and enhance the bioactive compounds and antioxidant potential in prickly pear peel infusions, promoting their sustainable utilization as functional ingredients in food and nutraceutical applications.
Mitochondrial Functionality Is Regulated by Alkylphospholipids in Human Colon Cancer Cells
Authors: Torrens-Mas Margalida , Collado-Solé Alejandro , Sola-Leyva Alberto , Carrasco-Jiménez María Paz , Oliver Jordi , Pons Daniel Gabriel , Roca Pilar , Sastre-Serra Jorge
Published: November 2023

Alkylphospholipids (APLs) have been studied as anticancer drugs that interfere with biological membranes without targeting DNA. Although their mechanism of action is not fully elucidated yet, it is known that they disrupt the intracellular trafficking of cholesterol and its metabolism. Here, we analyzed whether APLs could also interfere with mitochondrial function. For this purpose, we used HT29 colorectal cancer cells, derived from a primary tumor, and SW620 colorectal cancer cells, derived from a metastasis site. After treatment with the APLs miltefosine and perifosine, we analyzed various mitochondrial parameters, including mitochondrial mass, cardiolipin content, mitochondrial membrane potential, H2O2 production, the levels of oxidative phosphorylation (OXPHOS) complexes, metabolic enzymes activity, the oxygen consumption rate, and the levels of apoptosis and autophagy markers. APLs, especially perifosine, increased mitochondrial mass while OXPHOS complexes levels were decreased without affecting the total oxygen consumption rate. Additionally, we observed an increase in pyruvate dehydrogenase (PDH) and isocitrate dehydrogenase (IDH) levels and a decrease in lactate dehydrogenase (LDH) activity, suggesting a metabolic rewiring induced by perifosine. These alterations led to higher mitochondrial membrane potential, which was potentiated by decreased uncoupling protein 2 (UCP2) levels and increased reactive oxygen species (ROS) production. Consequently, perifosine induced an imbalance in mitochondrial function, resulting in higher ROS production that ultimately impacted cellular viability.
Preconditioning with Substance P Restores Therapeutic Efficacy of Aged ADSC by Elevating TNFR2 and Paracrine Potential
Authors: Piao Jiyuan , Cho Hyunchan , Park Jong Hyun , Yoo Ki Hyun , Jeong Ildoo , Hong Hyun Sook
Published: November 2023

Aging leads to a decline in stem cell activity by reducing the repopulation rate and paracrine potential, ultimately diminishing efficacy in vivo. TNF-α can exert inflammatory and cell death actions via Erk by binding to TNFR-1, and survival and tissue repair actions via Akt by binding to TNFR-2. Aged cells are reported to have insufficient expression of TNFR-2, indicating that aged adipose-derived stem cells (ADSCs-E) lack the ability for cell survival and immune control compared to young ADSCs (ADSCs-Y). This study aims to assess the preconditioning effect of SP on the response of ADSCs-E to inflammation. ADSCs-E were treated with SP and then exposed to a high dose of TNF-α for 24 h. Consequently, ADSC-E exhibited weaker viability and lower TNFR2 levels compared to ADSC-Y. In response to TNF-α, the difference in TNFR2 expression became more pronounced in ADSC-E and ADSC-Y. Moreover, ADSC-E showed a severe deficiency in proliferation and paracrine activity. However, preconditioning with SP significantly enhanced the viability of ADSCs-E and also restored TNFR2 expression and paracrine potential, similar to ADSC-Y under inflammatory conditions. Our findings support the idea that preconditioning with SP has the potential to restore the cellular function of senescent stem cells before transplantation.
The Diagnostic Landscape of Adult Neurogenetic Disorders
Authors: Waung Maggie W. , Ma Fion , Wheeler Allison G. , Zai Clement C. , So Joyce
Published: November 2023

Neurogenetic diseases affect individuals across the lifespan, but accurate diagnosis remains elusive for many patients. Adults with neurogenetic disorders often undergo a long diagnostic odyssey, with multiple specialist evaluations and countless investigations without a satisfactory diagnostic outcome. Reasons for these diagnostic challenges include: (1) clinical features of neurogenetic syndromes are diverse and under-recognized, particularly those of adult-onset, (2) neurogenetic syndromes may manifest with symptoms that span multiple neurological and medical subspecialties, and (3) a positive family history may not be present or readily apparent. Furthermore, there is a large gap in the understanding of how to apply genetic diagnostic tools in adult patients, as most of the published literature focuses on the pediatric population. Despite these challenges, accurate genetic diagnosis is imperative to provide affected individuals and their families guidance on prognosis, recurrence risk, and, for an increasing number of disorders, offer targeted treatment. Here, we provide a framework for recognizing adult neurogenetic syndromes, describe the current diagnostic approach, and highlight studies using next-generation sequencing in different neurological disease cohorts. We also discuss diagnostic pitfalls, barriers to achieving a definitive diagnosis, and emerging technology that may increase the diagnostic yield of testing.
A Spatial Transcriptome Reveals Changes in Tumor and Tumor Microenvironment in Oral Cancer with Acquired Resistance to Immunotherapy
Authors: Iwasa Yoh-ichiro , Nakajima Tomoyuki , Hori Kentaro , Yokota Yoh , Kitoh Ryosuke , Uehara Takeshi , Takumi Yutaka
Published: November 2023

Although anti-programmed death-1 (PD-1) antibody therapy improves the prognosis in patients with head and neck squamous cell carcinoma (HNSCC), some patients exhibit disease progression even after showing a good response to the treatment initially because of acquired resistance. Here, we aimed to reveal the dynamic changes in the tumor and tumor microenvironment (TME) in a 77-year-old man diagnosed with oral squamous cell carcinoma who developed acquired resistance after the administration of nivolumab using spatial transcriptomics. The results showed that, before immunotherapy, the activated pathways in the tumor area were mainly related to the cancer immune system, including antigen processing cross-presentation, interferon–gamma signaling, and the innate immune system. After immunotherapy, the activated pathways were mainly related to epigenetic modification, including RMTs methylate histone arginine and HDAC deacetylates histones. Before immunotherapy, the activated pathways in the TME were mainly related to the metabolism of proteins, including SRP-dependent co-translational protein targeting the membrane. After immunotherapy, the activated pathways in the TME were related to sensory perception and signal transduction. Our study revealed that epigenetic-modification-related pathways were mainly activated after establishing acquired resistance, suggesting that epigenetic modification in the tumor may prevent cancer immune system activation via the anti-PD-1 antibody.
The Prognosis Performance of a Neutrophil- and Lymphocyte-Associated Gene Mutation Score in a Head and Neck Cancer Cohort
Authors: Yeh Tsung-Jang , Wang Hui-Ching , Cho Shih-Feng , Wu Chun-Chieh , Hsieh Tzu-Yu , Huang Chien-Tzu , Wang Min-Hong , Chuang Tzer-Ming , Gau Yuh-Ching , Du Jeng-Shiun , Liu Yi-Chang , Hsiao Hui-Hua , Pan Mei-Ren , Chen Li-Tzong , Moi Sin-Hua
Published: November 2023

The treatment of head and neck squamous cell carcinomas (HNSCCs) is multimodal, and chemoradiotherapy (CRT) is a critical component. However, the availability of predictive or prognostic markers in patients with HNSCC is limited. Inflammation is a well-documented factor in cancer, and several parameters have been studied, with the neutrophil-to-lymphocyte ratio (NLR) being the most promising. The NLR is the most extensively researched clinical biomarker in various solid tumors, including HNSCC. In our study, we collected clinical and next-generation sequencing (NGS) data with targeted sequencing information from 107 patients with HNSCC who underwent CRT. The difference in the NLR between the good response group and the poor response group was significant, with more patients having a high NLR in the poor response group. We also examined the genetic alterations linked to the NLR and found a total of 41 associated genes across eight common pathways searched from the KEGG database. The overall mutation rate was low, and there was no significant mutation difference between the low- and high-NLR groups. Using a multivariate binomial generalized linear model, we identified three candidate genes (MAP2K2, MAP2K4, and ABL1) that showed significant results and were used to create a gene mutation score (GMS). Using the NLR-GMS category, we noticed that the high-NLR-GMS group had significantly shorter relapse-free survival compared to the intermediate- or low-NLR-GMS groups.
Translucent Zirconia in Fixed Prosthodontics—An Integrative Overview
Authors: Kui Andreea , Manziuc Manuela , Petruțiu Adrian , Buduru Smaranda , Labuneț Anca , Negucioiu Marius , Chisnoiu Andrea
Published: November 2023

Over the past two decades, dental ceramics have experienced rapid advances in science and technology, becoming the fastest-growing field of dental materials. This review emphasizes the significant impact of translucent zirconia in fixed prosthodontics, merging aesthetics with strength, and highlights its versatility from single crowns to complex bridgework facilitated by digital manufacturing advancements. The unique light-conducting properties of translucent zirconia offer a natural dental appearance, though with considerations regarding strength trade-offs compared to its traditional, opaque counterpart. The analysis extends to the mechanical attributes of the material, noting its commendable fracture resistance and durability, even under simulated physiological conditions. Various zirconia types (3Y-TZP, 4Y-TZP, 5Y-TZP) display a range of strengths influenced by factors like yttria content and manufacturing processes. The study also explores adhesive strategies, underlining the importance of surface treatments and modern adhesives in achieving long-lasting bonds. In the realm of implant-supported restorations, translucent zirconia stands out for its precision, reliability, and aesthetic adaptability, proving suitable for comprehensive dental restorations. Despite its established benefits, the review calls for ongoing research to further refine the material’s properties and adhesive protocols and to solidify its applicability through long-term clinical evaluations, ensuring its sustainable future in dental restorative applications.
Improving Cognitive Abilities in School-Age Children via Computerized Cognitive Training: Examining the Effect of Extended Training Duration
Authors: Wong Eugene H. , Rosales Kevin P. , Looney Lisa
Published: November 2023

Critical neuropsychological capabilities such as working memory, cognitive flexibility, and processing speed are foundational to many daily activities. For children, such skills are essential for school success. Thus, children who demonstrate weaknesses in these abilities may experience impaired academic performance; this is especially true for students identified with learning differences who often exhibit less developed cognitive abilities. The purpose of this project was to examine the efficacy of a cognitive training program implemented during the school day to improve abilities predictive of academic achievement. Ninety-five children completed two training activities that were counterbalanced across participants. Analyses of baseline working memory, cognitive flexibility, and processing speed performance relative to those following training showed a strong treatment effect. Moreover, there is notable evidence of greater intervention efficacy with extended engagement with the training program. Implications for neuropsychological research and practice are discussed.
A Multi-System Approach to Investigate Different Forms of Delinquency in Female Adolescents at Risk: Family, School, and Peers
Authors: Yeung Jerf W. K.
Published: November 2023

The delinquency of female adolescents at risk has increased conspicuously, much to the concern of human service and public health practitioners. Nevertheless, prior findings of pertinent research have commonly been based on samples of male or gender-mixed participants, especially general youths in the community. These cannot adequately explicate the impacts of different contextual systems on at-risk female adolescents, who are, in fact, more vulnerable to developing delinquency. Based on cross-sectional data collected from a sample of 236 at-risk female adolescents with the help of a large social work organization, the present study investigated and compared the effects of family, school, and peer systems on different forms of delinquency among at-risk female adolescents. The results show that positive family functioning, constructive school experiences, and deviant peer influence were predictive of both self-destructive and other-destructive delinquency in at-risk adolescent girls, respectively, but the effects were significantly different depending on which contextual systems influenced what forms of delinquency. Furthermore, the relationships between positive family functioning and both forms of delinquency were significantly mediated by the effects of constructive school experiences and deviant peer influence, giving support to the distal role of family and the proximal functions of school and peers in adolescence. Implications for policy prevention and interventions to strengthen the contextual supports in different social systems to help female adolescents at risk are discussed.
The Influence of Adverse Childhood Experiences on Malevolent Creativity in Young Adulthood
Authors: Ceballos Natalie A. , Watt Toni Terling
Published: November 2023

Background: Childhood trauma may increase the risk of antisocial behavior in young adulthood. Our study examined the relationship between Adverse Childhood Experiences (ACEs) and the specific antisocial behavior of malevolent creativity (MC), the application of original ideas to purposely harm others, often to gain an unfair advantage through manipulation, threat, or harm. Methods: We surveyed college students (N = 524; 78% women) on demographics, ACEs, empathy, social support, coping, general creativity, and malevolent creativity. The data were analyzed via sequential linear regression models. Results: Reporting ≥ 4 ACEs was associated with increased MC, which remained significant when general creativity and demographics were controlled. The association between higher ACEs and MC was no longer significant when psychosocial control variables (social support, empathy, and coping) were included in the statistical model. Social support and empathy were negatively associated with MC, while coping and MC were positively associated. Conclusions: ACEs may increase the likelihood of malevolent creativity in young adulthood, but empathy and social support may disrupt this trajectory. Care should be taken that coping skills, while typically viewed as a positive addition to one’s behavioral repertoire, do not push individuals toward over-reliance on themselves, which may reduce prosocial behaviors and increase MC.
Analysis of Pedestrian Behavior for the Optimization of Evacuation Plans in Tall Buildings: Case Study Santiago, Chile
Authors: Ternero Rodrigo , Sepúlveda Juan , Alfaro Miguel , Fuertes Guillermo , Vargas Manuel , Sepúlveda-Rojas Juan Pedro , Soto-Jancidakis Lukas
Published: November 2023

Countries located in the Pacific Ring of Fire, such as Chile, require robust evacuation plans for tall buildings to manage the ongoing threat of natural disasters. This study presents a methodology for developing evacuation plans by conducting pedestrian movement simulations with agents that have a model of their surroundings. This approach allows us to assess different scenarios and choose the best option based on the specific characteristics of the site. The method combines simulation and data analysis, using the Monte Carlo method to improve emergency evacuations. Initially, Pathfinder software was employed to simulate the evacuation of a tall building. This involved modeling pedestrian movements using a multiagent system. These agents were programmed to behave like real pedestrians and make decisions during evacuation scenarios, providing valuable information. The effectiveness of two evacuation strategies was then evaluated using the simulation data. The proposed methodology was validated using a case study. The simulations showed that the best strategy depends on factors such as the distribution of people, the capacity of the exits, and the time available for evacuation. Finally, the model includes a training process that uses virtual reality technology to improve situational awareness.
Cyclic Behavior of the Column-Tree Moment Connection with Weakened Plates: A Numerical Approach
Authors: Matthews Pablo , Núñez Eduardo
Published: November 2023

The use of column-tree connections is common in controlled shop environments due to their cost-effectiveness in achieving ductile welds. Field bolts are also easy to install and inspect. However, there is currently no prequalification available for these connections, their performance is not fully understood, and the cost of aftermath repairs is still a major concern for owners. In this research, analytical and numerical studies were performed to assess the cyclic behavior considering the effects of the bolted splice location, bolt slippage, and splice plate thickness. Fourteen numerical models using the finite element method in ANSYS software were analyzed to evaluate the nonlinear behavior of moment connection configurations in terms of the strength, stiffness, ductility, energy dissipation, and overall cyclic response. The results showed that appropriately proportioned bolted splice connections can meet the requirements for prequalified moment connections. The models complied with the criteria established in AISC 358 and achieved flexural resistance that was higher than 80% of the beam plastic moment at 4% of the interstory drift ratio. The weakened plates concentrated the inelastic action, which allowed us to prevent the brittle behavior and damage to the column, welding, and other components of the moment connection. Complex geometries or specially fabricated parts were not required, providing a cost-effective way to control seismic-related damage. Also, required repairs are based on the replacement of standard parts, reducing operational detentions in facilities. Finally, the moment connection studied is classified as partially restrained (PR) according to the requirements established in AISC 360.
A Digital Integrated Methodology for Semi-Automated Analysis of Water Efficiency in Buildings
Authors: Cortez-Lara Pedro , Sanchez Benjamin
Published: November 2023

Recent developments in the field of digital technologies in construction have led to a renewed interest in the use of building information modeling (BIM) for water efficiency analysis (WEA). BIM has emerged as a powerful platform for performance analysis towards sustainable design. However, there is little available in the literature on WEA using BIM. Extensive research has shown that WEA in buildings focuses on rating systems, 3D modeling, clash detection, and rainwater harvesting analysis. This paper presents a digital integrated methodology with in-depth analysis of three domains: (1) analysis of water usage according to plumbing fixtures and inhabitant demand per day, (2) sizing analysis of hydraulic-plumbing systems using the flowrate calculation method, and (3) analysis of alternative systems using harvested rainwater and treated water. The proposed methodology was applied to a multi-family building in Nuevo León, Mexico. The authors conclude that this methodology can easily be implemented in the short term, and that it may provide a significant improvement in WEA.
Electrocatalytic Treatment of Pharmaceutical Wastewater by Transition Metals Encapsulated by B, N-Doped CNTs
Authors: Sha Ou , Lu Xifeng , Su Pei
Published: November 2023

The electrochemical advanced oxidation process is a promising technology for tackling wastewater pollution, but it suffers from poor pH adaptability and slow catalytic kinetics in a neutral and alkaline environment in a homogeneous system, as well as fast release of metal ions in a heterogeneous system. Herein, a boron- and nitrogen-codoped carbon nanotube-encapsulated transition metal (M@BN-C, M–Co, Cu) cathode with a similar structure was synthesized to explore activity trends and mechanisms. Characteristics of Co@BN-C and Cu@BN-C cathodes were examined and compared with the previously synthesized Fe@BN-C bifunctional cathode. The activity of sulfamethazine (SMT) degradation by the Co@BN-C cathode was higher than both Fe@BN-C and Cu@BN-C at pH = 3 and pH = 7, respectively. However, the activity of Co@BN-C was also higher than that of Cu@BN-C and lower than that of Fe@BN-C at pH = 9. It was observed that •OH and 1O2 were the main reactive oxygen species (ROS) using Co@BN-C and Cu@BN-C cathodes. The Co@BN-C generated the highest •OH for efficient SMT degradation through abundant H2O2 generation, exhibiting the highest catalytic activity compared with the Cu@BN-C cathode. Overall, SMT degradation on the Co@BN-C cathode demonstrated better catalytic performance in real wastewater. This study provided insights into the fundamental catalytic trends and mechanisms of ROS production via the M@BN-C cathode, thus contributing to the development of the M@BN-C cathode for catalytic organic pollutant degradation.
Non-Invasive Evaluation of Retinal Vascular Alterations in a Mouse Model of Optic Neuritis Using Laser Speckle Flowgraphy and Optical Coherence Tomography Angiography
Authors: Buscho Seth E. , Xia Fan , Shi Shuizhen , Lin Jonathan L. , Szczesny Bartosz , Zhang Wenbo , Motamedi Massoud , Liu Hua
Published: November 2023

Optic neuritis, a characteristic feature of multiple sclerosis (MS), involves the inflammation of the optic nerve and the degeneration of retinal ganglion cells (RGCs). Although previous studies suggest that retinal blood flow alterations occur during optic neuritis, the precise location, the degree of impairment, and the underlying mechanisms remain unclear. In this study, we utilized two emerging non-invasive imaging techniques, laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA), to investigate retinal vascular changes in a mouse model of MS, known as experimental autoimmune encephalomyelitis (EAE). We associated these changes with leukostasis, RGC injury, and the overall progression of EAE. LSFG imaging revealed a progressive reduction in retinal blood flow velocity and increased vascular resistance near the optic nerve head in the EAE model, indicating impaired ocular blood flow. OCTA imaging demonstrated significant decreases in vessel density, number of junctions, and total vessel length in the intermediate and deep capillary plexus of the EAE mice. Furthermore, our analysis of leukostasis revealed a significant increase in adherent leukocytes in the retinal vasculature of the EAE mice, suggesting the occurrence of vascular inflammation in the early development of EAE pathology. The abovechanges preceded or were accompanied by the characteristic hallmarks of optic neuritis, such as RGC loss and reduced visual acuity. Overall, our study sheds light on the intricate relationship between retinal vascular alterations and the progression of optic neuritis as well as MS clinical score. It also highlights the potential for the development of image-based biomarkers for the diagnosis and monitoring of optic neuritis as well as MS, particularly in response to emerging treatments.
Parent Perspectives: Part 2—Considerations for the Transition Home Post-NICU Discharge
Authors: DiBari Jessica N. , Rouse LaToshia
Published: November 2023

This paper is part two of a series of papers written by the mothers of Neonatal Intensive Care Unit (NICU) graduates. The companion paper, “Parent Perspectives: Part 1—Considerations for Changing the NICU Culture”, considers all aspects of the NICU experience and provides recommendations for interventions and improvements from a life-course perspective while families are in the NICU. In part two, the focus is the transition home post-NICU stay. The time after NICU discharge is a critical and sensitive developmental period for NICU babies and their families, and an important life course transition. This paper provides a parent’s perspective of how to improve the transition home post-NICU stay. Our perspectives draw on the Life Course Health Development approach, which regards health as an active process that is developed over time based on a person’s internal biologic and physiologic systems, their external environment and circumstances, and the interactions or relationships between them. This paper describes a collaborative care model where parents and their healthcare teams work together to develop shared care plans. It also describes how we can build trust and family capacity to support long-term care, ensure family well-being, and link families to needed resources and support that can ease the transition from the NICU back to the home and optimize family health trajectories.
Patient-Reported Outcome Measures of Flapless Corticotomy with Low-Level Laser Therapy in En Masse Retraction of Upper Anterior Teeth: A Three-Arm Randomized Controlled Trial
Authors: Mousa Mudar M. , Hajeer Mohammad Y. , Burhan Ahmad S. , Darwich Khaldoun M. A. , Almahdi Wael H. , Aljabban Ossama , Awawdeh Mohammed A. , Almasri Imad Addin
Published: November 2023

(1) Background: This study aimed to compare patient-reported outcome measures when accelerating en masse retraction between the piezocision procedure and the subsequent application of low-level laser therapy (FC+LLLT), with the piezocision alone (FC), and in a control group. (2) Methods: A three-arm randomized controlled trial (RCT) was conducted involving 60 patients (41 females and 19 males) with Class II division I malocclusion. The en masse retraction was performed using NiTi closed coil springs attached to miniscrews. The LLLT was performed using an 808 nm Ga-Al-As diode laser. Patient responses regarding pain, discomfort, swelling, and chewing difficulties were reported at ten assessment points. (3) Results: The greatest pain levels were observed 24 h after the application of force during the first and third months of retraction. The mean pain, discomfort, swelling, and chewing difficulties were significantly smaller in the control group than in the FC and FC+LLLT groups. High satisfaction levels were reported in all three groups (p < 0.05). (4) Conclusions: The accelerated en masse retraction via piezocision, followed by a small course of LLLT, was accompanied by significantly fewer pain, discomfort, and chewing difficulties than the control group. LLLT is a valuable addition to piezocision, with an improved patient experience.
Surface Roughness Effects on Magnetic Properties and Switching Mechanism in Iron Nanowires
Authors: Pastukh Oleksandr , Kuźma Dominika , Zieliński Piotr
Published: November 2023

Nanowires fabricated with experimental techniques are never perfect and possess structural imperfections. The effect of the resulting surface roughness on magnetic properties of iron nanowires has been simulated here with the use of numerical technique involving atomistic-resolved software Vampire. A two-regime or a power-law decrease in the coercive field has been found for the roughness amplitude up to 30% of the perfect radius of the wire. The roughness of the surface of the side face of cylindrical wire makes the ends of the cylinder inequivalent as far as the switching mechanism is concerned. As a result, the switching becomes dominated by a transverse domain wall arising at one specific end only. Both the coercive field and the switching mechanism are essential in designing magnetic devices, e.g., for memory storage.
Diversity of Gut Microbes in Adult Vespa velutina (Asian Hornet) Carcasses Killed by Natural Causes
Authors: Pang Meiling , Luo Ji , Yang Zhende , Jiang Xuejian
Published: November 2023

[Objective] This study’s objective was to investigate the diversity of intestinal microorganisms in adult Vespa velutina (Asian hornet) killed by natural causes. This study investigates the composition of intestinal fungi and bacteria and predicts the pathogenic pathogen in adult Vespa velutina (Asian hornet). [Methods] We determined the ITS1 sequence of fungi and the V3–V4 variant region of 16S rRNA of bacteria using Illumina MiSeq technology. Operational taxonomic units (OTU) of gut symbiotic microorganisms were quantified, and the resulting data were subjected to analysis of species abundance, composition, and alpha diversity. OTU function was predicted using PICRUSt2/FUNGuild. In addition, cultured microorganisms from the gut microbiota of adult Vespa velutina were isolated and identified. A number of 3610 (fungi) and 8373 (bacteria) were identified via cluster analysis. A total of 13 strains, 51 classes, 126 orders, 285 families, and 586 genera were identified for fungi and 44 strains, 113 classes, 319 orders, 662 families, and 1394 genera were identified for bacteria. E. shigella, Herbaspirillum, and Aaaia were the most abundant classes of bacteria, and Fusarium, Mortierella, and Starmerella were the most abundant classes of fungi. In addition, 16 community genera of fungi and 11 of bacteria were outlined as core taxa. Species diversity and richness for the gut fungal and bacterial communities with VN were found to be higher than those with VA. Furthermore, bacterial species diversity and richness were found to be higher than those of fungi in VA and VN. Functional analysis revealed that Vespa velutina gut bacteria exhibited 20 functions, while fungi were classified into three types of nutrient modes. Cultivable bacteria were obtained from two phyla and two classes, but no fungi could be cultivated. [Conclusion] Variations in the species diversity and abundance of both fungi and bacteria in the gut were observed between the VA and the VN. The involvement of bacteria in the death of adult Vespa velutina was found to be significant. In addition, VA1 (the self-named strain) may be a pathogenic bacterium derived from the gut of the VA that exhibits virulence.
A Combination of Ultrasound Characteristics with Macroscopic and Biochemical Features to Diagnose the Etiology of Lymphocytic Pleural Effusions
Authors: Piskac Zivkovic Nevenka , Cvetko Danijel , Zivkovic Marcela , Simac Brankica , Zelenika Margeta Marina , Kovacevic Ivona , Malnar Janes Linda , Lalic Kristina , Guzvinec Zvonka , Ljilja Posavec Anja , Feljan Hrvoje , Vergles Mirna , Kuster Zeljko
Published: November 2023

Objectives: The primary aim of this study was to improve the diagnosis of lymphocytic pleural effusions (LPEs) by combining their ultrasound characteristics with their macroscopic and biochemical features. Methods: This prospective, single-center, clinical observational study was conducted over a period of three years. The possible malignant etiology of LPEs was assessed using several diagnostic criteria: 1. ultrasound characteristics of the LPEs; 2. typical combinations of macroscopic and ultrasound features; and 3. the logistic regression method with three parameters—pleural nodularity, absence of fibrin, and serum protein concentration. Results: Eighty-four patients with LPEs were included in this study. Pleural nodularity (first criterion) was an ultrasound characteristic that yielded the best individual results (p < 0.001) in the differentiation of malignant and nonmalignant etiologies of LPEs (accuracy 73.81%). The combination of the second and third criteria yielded the best results in the prediction of a malignant etiology of LPEs (sensitivity 90.48%, specificity 83.33%, PPV 84.44%, NPV 89.74%, accuracy 86.90%). Based on the results of this prospective study, a protocol for the diagnostic procedure of lymphocytic pleural effusions without a definitive fluid diagnosis has been proposed. Conclusions: A combination of the ultrasound characteristics of LPEs and their macroscopic and biochemical features has improved the predictive accuracy for the malignant etiology of LPEs.
Downregulation of Glycine N-Acyltransferase in Kidney Renal Clear Cell Carcinoma: A Bioinformatic-Based Screening
Authors: Muñoz Juan P. , Calaf Gloria M.
Published: November 2023

Clear cell renal cell carcinoma (KIRC) is the most common subtype of renal cell carcinoma (RCC). This form of cancer is characterized by resistance to traditional therapies and an increased likelihood of metastasis. A major factor contributing to the pathogenesis of KIRC is the alteration of metabolic pathways. As kidney cancer is increasingly considered a metabolic disease, there is a growing need to understand the enzymes involved in the regulation of metabolism in tumorigenic cells. In this context, our research focused on glycine N-acyltransferase (GLYAT), an enzyme known to play a role in various metabolic diseases and cancer. Here, through a bioinformatic analysis of public databases, we performed a characterization of GLYAT expression levels in KIRC cases. Our goal is to evaluate whether GLYAT could serve as a compelling candidate for an in-depth study, given its pivotal role in metabolic regulation and previously established links to other malignancies. The analysis showed a marked decrease in GLYAT expression in all stages and grades of KIRC, regardless of mutation rates, suggesting an alternative mechanism of regulation along the tumor development. Additionally, we observed a hypomethylation in the GLYAT promoter region and a negative correlation between the expression of the GLYAT and the levels of cancer-associated fibroblasts. Finally, the data show a correlation between higher levels of GLYAT expression and better patient prognosis. In conclusion, this article underscores the potential of GLYAT as a diagnostic and prognostic marker in KIRC.
Identifying Facilitators and Barriers in Quebec Schools to Promote Inclusive Physical Education
Authors: Hebinck Margaux , Boisvert Maxence , Labbé Mariève , Périnet-Lacroix Roxanne , Brisebois Jérémie , Best Krista L. , Robert Maxime T.
Published: November 2023

Inclusive physical education allows the development of social skills, attitudes, and awareness of peers about functional limitations and enhances the leadership skills of all children. However, the positive experience of children with functional limitations in inclusive physical education can be impacted by programs inadequate to their abilities and the limited training and knowledge of physical educators about teaching in consideration of their needs. The objective of this study was to identify the facilitators and barriers experienced by physical educators to include children with functional limitations in physical education in Quebec schools. A cross-sectional descriptive study with an online survey was conducted with physical education teachers and daycare educators. Descriptive statistics were used to analyze the data. A total of 149 participants (n = 130 physical education teachers) responded to the survey. Most respondents (79.5%) included children with functional limitations in activities with their classmates. However, 39.4% of respondents reported feeling not informed and not equipped to facilitate inclusion. This study identified the facilitators and barriers to physical education for children with functional limitations from the perspectives of physical educators, in Quebec schools, and the role of the latter to encourage inclusion.
Pointer States and Quantum Darwinism with Two-Body Interactions
Authors: Duruisseau Paul , Touil Akram , Deffner Sebastian
Published: November 2023

Quantum Darwinism explains the emergence of classical objectivity within a quantum universe. However, to date, most research on quantum Darwinism has focused on specific models and their stationary properties. To further our understanding of the quantum-to-classical transition, it appears desirable to identify the general criteria a Hamiltonian has to fulfill to support classical reality. To this end, we categorize all N-qubit models with two-body interactions, and show that only those with separable interaction of the system and environment can support a pointer basis. We further demonstrate that “perfect” quantum Darwinism can only emerge if there are no intra-environmental interactions. Our analysis is complemented by solving the ensuing dynamics. We find that in systems exhibiting information scrambling, the dynamical emergence of classical objectivity directly competes with the non-local spread of quantum correlations. Our rigorous findings are illustrated through the numerical analysis of four representative models.
The Relationship between the School as a Learning Organisation and Teacher Job Satisfaction in General Education in Latvia
Authors: Lūsēna-Ezera Inese , Siliņa-Jasjukeviča Gunta , Kaulēns Oskars , Linde Inga , Līduma Diāna
Published: November 2023

The purpose of the study was to examine the relationship between the school as a learning organisation (SLO) and teacher job satisfaction in general education in Latvia. This study also examined teacher job satisfaction depending on the school type (primary, elementary and secondary school), school size, the geographical location of the school, the teacher’s work experience, the teacher’s workload and whether the teacher’s has one or more jobs. A structured questionnaire on the eight dimensions of the Latvian SLO model was used, which was developed within the project, “A model and tool to support the implementation of the approach school as a learning organisation in educational institutions”. The study sample included 478 teachers from 62 general educational institutions in Latvia. A significant relationship was found between all SLO dimensions and teacher job satisfaction in general education in Latvia. A significant relationship was not found between teacher job satisfaction and the school type, the school size, the geographical location of the school and the teacher’s work experience and workload; however, the data reveal that teachers who have almost full-time or full-time employment at school and those who work in only one school are more satisfied with their work.
Development of Mobile App to Enable Local Update on Mapping API: Construction Sites Monitoring through Digital Twin
Authors: Valenzuela Alfredo , Choi Jongseong Brad , Ortiz Ricardo , Kang Byungkon , Kim Michael , Kang Taewook
Published: November 2023

Unmanned ground vehicles (UGVs) have emerged as a promising solution for reconnaissance missions, overcoming labor cost, frequency, and subjectivity issues associated with manual procedures. However, for dynamic environments such as construction sites, the constantly changing conditions hinder a manager from planning the UGV’s paths. For an autonomous monitoring mission, the path planning should be dealt with by having a map with the site’s most recent scene. In this study, we develop a mobile app capable of local map updates by overlaying an image on a mapping API (e.g., Google Maps) hence working as a digital twin capable of creating a dynamic representation of the updated terrain over the mapping API. UGV operators can draw a path on such an updated construction scene using a tablet PC or smartphone. Discrete GPS information (e.g., latitudinal, and longitudinal) is executed for the UGV’s controller. In the overlaying procedure, the homographic relation between the image and map is automatically computed and then projected. We successfully demonstrated the capabilities of the technique with two construction sites and a soccer field using images from the ground and satellite, respectively. The error generation is quantitatively measured and analyzed.
Temporal Analysis of Energy Transformation in EU Countries
Authors: Ziemba Paweł , Zair Abdullah
Published: November 2023

Due to the environmental policy adopted by the European Union (EU), EU countries are obliged to reduce greenhouse gas emissions. They reduce emissions largely through the energy transformation and switching to renewable energy sources (RES). Therefore, it is important to assess the progress of the energy transformation of individual EU countries. This is related to the aim of the article, which is a temporal analysis of the energy transformation process towards the transition to RES and reducing the use of fossil fuels in energy production. To achieve this goal, a new Temporal/Dynamic Multi-Criteria Decision-Making (T/DMCDM) method called Temporal PROSA was developed, based on the PROMETHEE and PROSA family of methods. The Temporal PROSA method, unlike many other T/DMCDM methods, enables the aggregation of data from many periods into a single final assessment, as well as the direct transfer of information from the examined periods to the overall result. As a result of the research, EU countries that dominated in terms of progress in energy transformation towards RES in the years 2004–2021were identified. Based on the data and methodology used, it was indicated that these countries are primarily Sweden and Portugal, and recently also Denmark and Finland. On the other hand, countries such as Belgium, Bulgaria, Cyprus, Luxembourg, and Poland made the least progress between 2004 and 2021.
Energy Status in Africa: Challenges, Progress and Sustainable Pathways
Authors: Agoundedemba Maklewa , Kim Chang Ki , Kim Hyun-Goo
Published: November 2023

Access to modern energy is essential for socioeconomic development, yet Africa faces significant challenges in this regard. For example, Sub-Saharan Africa (SSA) is marked by economic underdevelopment and poverty largely due to the non-environmentally friendly energy used (wood, charcoal) and limited access to modern energy resources. Indeed, this review provides an overview of the African energy landscape; it provides a comprehensive renewables-focused energy pathway for developing a cleaner and more sustainable African energy system. It explores end-use sector electrification in both rural and urban areas in Africa. It emphasizes the rapid expansion of renewable generation, the challenges facing and solutions for the implementation of renewable energy, and the role of emerging technologies. It also presents technological pathways and investment opportunities that will enrich the regional debate and help accelerate the energy transformation across Africa. The analysis demonstrated that the current trends of renewable energy used are hydropower, wind power, biomass, and geothermal energy. The electrification rate in West Africa is less than 58% in urban areas and less than 25% in rural areas. Results show that 65% of the SSA population does not have access to electricity and 81% rely on wood and charcoal. In West Africa, only Ghana (70% or so) and Cape Verde (95.9% or so) have equitable access to electricity between rural and urban areas. The potentiality of solar irradiance in Africa ranges between 3 and 7 KWh/m2/day. The wind speed ranges from 3 m/s to 10 m/s; the wave power can range from 7 to 25 kW/m per site in island regions. Egypt, Morocco, Ethiopia, Tunisia, and South Africa are, respectively, countries leading in wind power technology, and solar energy technology was more advanced in North Africa and South Africa. Finally, geothermal is only developed in Kenya and Tanzania and Kenya is the leader in that field. Although renewable energy in Africa is still growing year to year, it still faces power outages because most renewable energy potentialities are not yet exploited, the technologies used are weak, there is insufficient funding, there is ineffective infrastructure, and there are inadequate or no policies in that field.
Estimating Compressional Velocity and Bulk Density Logs in Marine Gas Hydrates Using Machine Learning
Authors: Naim Fawz , Cook Ann E. , Moortgat Joachim
Published: November 2023

Compressional velocity (Vp) and bulk density (ρb) logs are essential for characterizing gas hydrates and near-seafloor sediments; however, it is sometimes difficult to acquire these logs due to poor borehole conditions, safety concerns, or cost-related issues. We present a machine learning approach to predict either compressional Vp or ρb logs with high accuracy and low error in near-seafloor sediments within water-saturated intervals, in intervals where hydrate fills fractures, and intervals where hydrate occupies the primary pore space. We use scientific-quality logging-while-drilling well logs, gamma ray, ρb, Vp, and resistivity to train the machine learning model to predict Vp or ρb logs. Of the six machine learning algorithms tested (multilinear regression, polynomial regression, polynomial regression with ridge regularization, K nearest neighbors, random forest, and multilayer perceptron), we find that the random forest and K nearest neighbors algorithms are best suited to predicting Vp and ρb logs based on coefficients of determination (R2) greater than 70% and mean absolute percentage errors less than 4%. Given the high accuracy and low error results for Vp and ρb prediction in both hydrate and water-saturated sediments, we argue that our model can be applied in most LWD wells to predict Vp or ρb logs in near-seafloor siliciclastic sediments on continental slopes irrespective of the presence or absence of gas hydrate.