bluuebunny/crossref_metadata_2025 huggingface dataset:
БУДДИЙСКИЙ СПЕКТР: СОДЕЙСТВИЕ БУДДИЙСКО-ХРИСТИАНСКОМУ ДИАЛОГУ
Authors: ПАЛЛИС МАРКО
Published: July 2022

Книга представляет собой впервые публикуемый на русском языке перевод сборника эссе «Буддийский спектр. Содействие буддийско-христианскому диалогу», изданного в 1980 г. Марко Паллисом (1895-1989). Она является заключительной книгой трилогии, первые две из которой «Пики и ламы» и «Путь и гора» были изданы в 1936 и 1961 гг. Альпинист и музыкант, исследователь гималайского региона, философ и преданный последователь буддийской традиции М. Паллис в заключительной работе подвёл итог своему видению философии традиционализма и перенниализма, последовательно сопоставляя основополагающие принципы, лежащие в основе буддийской и христианской традиций. Присущий автору деликатный стиль изложения позволяет с лёгкостью подступиться к осмыслению метафизики, лежащей в основе всех религий, а также строящихся на ней эзотерических практик и путей духовной реализации. Перевод с английского языка сопровождён комментариями, а также предваряется вступительной статьёй, знакомящей читателя с основными этапами жизни и творчества М. Паллиса. Книга ориентирована как на востоковедов, так и на широкий круг читателей, интересующихся буддизмом, религиозной философией и сравнительным изучением культур.
Analysis of pneumococcal serotypes distribution to determine a model composition for a Russian pneumococcal conjugate vaccine
Authors: Trukhin V. P. , Evtushenko A. E. , Salimova E. L. , Konon A. D. , Khaitov M. R. , Merkulov V. A.
Published: July 2022

Diseases caused by Streptococcus pneumoniae, as well as antibiotic resistance of its serotypes, are the leading cause of death amongst children worldwide. To prevent pneumococcal infection, the population is immunised with conjugate vaccines containing different amounts of polysaccharides of certain serotypes. Development of a full-cycle Russian vaccine is vital because the active pharmaceutical ingredients for the vaccines registered in the Russian Federation are produced abroad, and only the final stages of production of vaccines of this group are performed in the territory of the Russian Federation. Considering the phenomenon of serotype replacement associated with the long-term widespread use of pneumococcal conjugate vaccines, it is necessary to carefully select the serotype composition for the new vaccine. The aim of this work was to analyse the serotype distribution of pneumococci in the Russian Federation and other countries in order to select optimal serotypes for the Russian vaccine for human use, taking into account vaccination schedules for each age group. This review presents an analysis of the pneumococcal serotype distribution in the Russian Federation in the pre-vaccination era, as well as after the introduction of routine vaccination. In addition, the review includes data on the serotype distribution in the Eurasian Economic Union countries. The authors described a model composition containing at least sixteen serotypes. It will increase effectiveness of immune protection of the population, providing a more complete coverage of serotypes, considering their prevalence in the Russian Federation. Based on the analysis, the serotype composition for the sixteen-valent pneumococcal conjugate vaccine is proposed for further production and preclinical and clinical trials. A new Russian pneumococcal conjugate vaccine will ensure vaccination of all population groups within the National Immunisation Schedule of the Russian Federation.
Prospects for ion chromatography in quality assessment of biologicals
Authors: Minero A. S. , Runova O. B. , Ustinnikova O. B. , Movsesyants A. A.
Published: July 2022

Quantitative characterisation of excipients in biologicals is an important part of the quality assurance process both at the level of finished products and intermediates, as well as active pharmaceutical ingredients. Ion chromatography with amperometric and conductometric detection of separation products has a number of advantages. The main of the advantages is the possibility of direct determination of semivolatile compounds that have neither chromophoric groups, nor intrinsic fluorescence. The aim of this study was to compare ion chromatography with alternative methods in order to identify promising areas for its use in assessing the quality of biologicals. The authors analysed regulatory documents and literature and summarised the methods applied for quantitative determination of ionic excipients in biological medicinal products. The authors investigated the possibility of using ion chromatography for determination of the main active pharmaceutical ingredient in polysaccharide vaccines and excipients in biologicals. The study demonstrated the feasibility of ion chromatography for simultaneous quantitation of cations (ammonium, calcium, magnesium) and anions (chlorides, sulfates, nitrates) in reconstitution solvents for lyophilised biologicals; quality assessment of active pharmaceutical ingredients in biologicals (quantitative analysis of polysaccharides in polysaccharide vaccines, profiling of glycosylated proteins, etc.); and determination of several carbohydrate stabilisers in biologicals with the same analytical procedure. According to the conclusions, ion-exchange chromatography with conductometric and amperometric detection, aimed at quality assessment of biological products, can shortly take a leading position in quantitation of ionic excipients, carbohydrate stabilisers, and main active ingredients (polysaccharides) in polysaccharide vaccines, including the vaccines in the immunisation schedule.
Development of a protective lyophilisation medium and conditions to stabilise the erythrocyte diagnostic preparation of tularaemia immunoglobulin
Authors: Kurcheva S. A. , Koshkidko A. G. , Zharnikova I. V. , Rusanova D. V. , Semircheva A. A. , Startseva O. L. , Zhdanova E. V. , Kurnoskina M. M. , Tyumentseva I. S.
Published: July 2022

Liquid erythrocyte diagnostic preparations have a practical disadvantage; i.e., long-distance transportation involving possible non-compliance with cold-chain requirements may result in a complete loss of biological activity. A lyophilisation technology is necessary to ensure that the preparations retain their original properties for a long time. The aim of the work was to develop a protective medium and conditions for lyophilisation to stabilise the erythrocyte diagnostic preparation of tularaemia immunoglobulin. Materials and methods: Gelatin, thiourea, trehalose, sucrose, dextran, and Tween 80 were used as excipients for protective media. The authors used nine strains of homologous and heterologous microorganisms of different genera and species to control the lyophilised diagnostic preparation sensitivity and specificity. Evaluation of the main stability-related quality attributes (appearance of the dried preparation, loss on drying, solubility, appearance after reconstitution, appearance after settling, sensitivity, specificity) considered the temperatures specific to the climatic zones where the in vitro diagnostics is intended to be marketed and used. Results: The authors developed protective stabilising media with different compositions, used them in freeze-drying of the preparation and carried out control testing. The most promising was the lyophilisation medium containing a smaller amount of ingredients —6% of dextran, 0.06% of Tween 80 and up to 0.01% of sodium azide—as it was the simplest one to prepare and ensured complete preservation of the quality attributes. The authors carried out practical evaluation of lyophilisation procedures, and the 12–14-hour procedure proved to be the most cost-effective. Conclusions: The results of long-term, or real time, and accelerated stability testing of the lyophilised diagnostic preparation demonstrated the possibility of two-year storage at a labelled temperature of 2–8 °C, as well as at elevated and low temperatures of 30±2 °С and –18 °С, respectively. The tests showed no negative effects of the temperatures on the controlled quality attributes.
Assessment of Safety Signals for Aztreonam in Different Age Groups: National and International Drug Safety Monitoring
Authors: Sokova E. A. , Arkhipov V. V. , Kazakov A. S. , Romanov B. K. , Alyautdin R. N. , Zhuravleva M. V.
Published: July 2022

Aztreonam is the only approved monocyclic β-lactam antibiotic for human use that is active against Gram-negative aerobes, primarily Pseudomonas аeruginosa. Aztreonam has been used for more than 35 years, and aztreonam lysine has been on the market for 15 years. Although the medicinal products show clinical and microbiological efficacy in severe infections and are significant for cystic fibrosis patients, little information is published on their safety. In the meantime, new data have accumulated.

The aim of the study was to analyse the data on adverse reactions in patients of different age groups receiving aztreonam, collected in the safety monitoring databases VigiBase and Pharmacovigilance.

Materials and methods: the data on adverse reactions associated with aztreonam, in any dosage form, from the individual case reports submitted to VigiBase (the database of the Uppsala Monitoring Centre) before 15.09.2021 and to Pharmacovigilance (the database for spontaneous reports in the Automated Information System of the Federal Service for Surveillance in Healthcare of the Russian Federation) before 05.10.2021.

Results: the analysis of adverse reactions during the use of aztreonam for approved indications showed differences in frequency, types and severity of the adverse reactions amongst the age groups. The most common adverse reaction with aztreonam was cystic fibrosis referred to in 1828 reports (12.0%). It was recorded more often in patients aged 18–44 years (39.2%).

Conclusions: the data obtained allowed the authors to identify a new safety signal for aztreonam, namely an increased risk of inefficacy or insufficient efficacy in cystic fibrosis considered an adverse reaction in the individual reports from the databases of spontaneous reports. Confirmation of the signal requires further monitoring.
Experimental Study of the Efficacy and Safety of a New PEG-Based Laxative
Authors: Shekunova E. V. , Mazukina E. V. , Vavilova V. A. , Kashkin V. V. , Balabanyan V. Yu. , Fazylov M. F. , Makarova M. N. , Makarov V. G.
Published: July 2022

Bowel-cleansing PEG-based agents, including Moviprep®, are commonly used to prepare the large intestine for diagnostic examinations. PLNV-next is a newly developed fixed combination medicinal product with a composition similar to that of Moviprep®.

The aim of the study was to estimate the pharmacological efficacy and toxicity of PLNV-next.

Materials and methods: The study evaluated pharmacological efficacy of four formulations of PLNV-next in comparison with Moviprep® after a single administration in a therapeutic dose to outbred rats. The evaluation was carried out based on the laxative effect of the medicinal products. The authors recorded diarrhoea onset latency and the number of defecation boluses and diarrhoea spots produced during the 6-hour observation period. Toxicity of PLNV-next was studied in the formulation containing maximum amounts of the ingredients according to the patent. In the single-dose toxicity study, PLNV-next was administered intragastrically to rats at doses of 4.2 g/kg (maximum human therapeutic dose, MHTD), 21 g/kg (5 MHTD), and 42 g/kg (10 MHTD) and to ferrets at doses of 4.2 g/kg (MHTD) and 21 g/kg (5 MHTD). In the repeated-dose toxicity study, PLNV-next was administered for 14 days at 4.2 g/kg (rats and ferrets), 21 g/kg (5 MHTD, rats), and 12.6 g/kg (3 MHTD, ferrets). Additionally, the repeated-dose toxicity study evaluated safety pharmacology parameters for the cardio-vascular, respiratory and central nervous systems.

Results: All PLNV-next formulations tested exerted a laxative effect equivalent to that of Moviprep®. No clinical signs of toxicity were observed in rats, with the exception of the laxative effect. Ferrets demonstrated decreased behavioral activity and diarrhoea. Nausea or emesis were noted in 75–90% of the ferrets receiving the doses exceeding the MHTD. A single administration of PLNV-next affected blood sodium concentrations: a slight increase was noted in the 5 MHTD and 10 MHTD groups of rats and in the 5 MHTD group of ferrets. The repeated-dose toxicity study in rats revealed a slight increase in sodium levels with both test doses. After a single administration of 5 MHTD to ferrets, the authors observed a decrease in potassium levels. All the changes were mild and within physiological ranges. PLNV-next toxic effects observed in the rat and ferret studies were similar to those reported in rat and dog toxicity studies of Moviprep®. 

Conclusion: PLNV-next exerts a marked laxative effect and has a favourable safety profile.
Анализ элеутерозидов в тандемной масс-спектрометрии: возможности стандартизации мультифитоадаптогена для профилактической онкологии
Authors: Бочарова О. А. , Шевченко В. Е. , Казеев Илья В. , Шейченко О. П. , Ионов Н. С. , Бочаров Е. В. , Карпова Р. В. , Аксенов А. А. , Поройков В. В. , Кучеряну В. Г. , Косоруков В. С.
Published: July 2022

С применением высокоэффективной жидкостной хроматографии в сочетании с тандемной масс-спектрометрией проведен анализ биологически активных веществ в экстракте корневищ и корней элеутерококка колючего Eleutherococcus senticosus (Rupr. & Maxim) Maxim, семейства Аралиевые (Araliaceae), а также в составе фармацевтической композиции Мультифитоадаптоген. Хроматографирование проводили на колонке ACQUITY UPLC BEH C18 в градиентном режиме. Использовали тройной квадрупольный масс-спектрометр TSQ Vantage с электрораспылительной ионизацией. В мультифитоадаптогене, как и в экстракте корневищ и корней элеутерококка, были идентифицированы элеутерозиды В (сирингин – фенилпропаноид) и Е (диглюкозид сирингарезинола – лигнан). В результате анализа профилей биологической активности in silico установлены вероятные механизмы противоопухолевого действия и аддитивные/синергетические эффекты элеутерозидов B и E.
Эффективность ремаксола у пациентов с алкогольной болезнью печени
Authors: Стельмах Виктория Валерьевна , Бакулин Игорь Геннадьевич , Коваленко Алексей Леонидович , Козлов Виктор Константинович
Published: July 2022

Обследовано 85 пациентов с алкогольной болезнью печени (АБП) в возрасте от 24 до 70 лет. Пациенты основной группы (n = 50) в составе комплексной терапии получали ремаксол: ежедневно (10 – 12 дней) внутривенно капельно по 400 мл 1 раз в сутки; пациентам группы сравнения (n = 35) вводили адеметионин (800 мг, внутривенно) 1 раз в сутки в течение 10 – 12 дней. Включение ремаксола в комплексное лечение пациентов с АБП на цирротической стадии способствовало улучшению компенсаторных возможностей печени и краткосрочного жизненного прогноза: в 2,3 раза уменьшилось количество больных со значением расчетного индекса MELD > 11 в основной группе, по сравнению с 1,4 раза в группе сравнения; установлено статистически значимое различие в динамике показателей синдрома цитолиза у пациентов основной группы (снижение активности аланинаминотрансферазы с 108,2 ± 25,0 до 56,8 ± 15,1 ЕД/л, p < 0,05, аспартатаминотрансферазы с 115,1 ± 12,6 до 59,7 ± 16,3 ЕД/л, p < 0,05), по сравнению с аналогичными показателями группы сравнения (снижение аланинаминотрансферазы с 90,9 ± 21,3 до 81,0 ± 11,3 ЕД/л, p > 0,05, аспартатаминотрансферазы с 128,6 ± 10,3 до 82,9 ± 10,6 ЕД/л, p < 0,05). Отмечен выраженный антихолестатический эффект ремаксола у больных алкогольным стеатогепатитом: снижение активности гамма-глутамилтранспептидазы с 611,4 ± 68,1 до 330,9 ± 42,1 ЕД/л, (p < 0,05) у пациентов основной группы, по сравнению со снижением активности этого фермента с 437,0 ± 54,2 до 290,1 ± 46,1 ЕД/л, (p < 0,05) в группе сравнения, при этом кратность снижения составила 1,9 в основной группе и 1,5 раза в группе сравнения, соответственно. В основной группе больных наблюдали улучшение белково-синтетической функции печени (по увеличению синтеза альбумина гепатоцитами с 31,9 ± 0,5 до 36,3 ± 0,8 г/л в основной группе, p < 0,05, по сравнению с таковыми показателями в группе сравнения с 29,4 ± 1,1 до 30,6 ± 1,3 г/л, p > 0,05). После завершения применения лекарственных средств у 74 % пациентов с АБП основной группы выявлено повышение уровня тромбоцитов: с (99,7 ± 12,9)  109/л до (137,6 ± 19,1) · 109/л (p < 0,05) и лишь у 50 % больных группы сравнения: с (123,3 ± 11,2) · 109/л до (163,1 ± 18,5) · 109/л (p < 0,05)). Ремаксол положительно влияет на клиническое течение АБП, в том числе, на цирротической стадии, способствует улучшению краткосрочного жизненного прогноза (по индексу MELD), существенно уменьшает выраженность основных клинических синдромов (астено-вегетативного, диспепсического, холестатического), способствует развитию дезинтоксикационного, мембраностабилизирующего, цитопротекторного, а также выраженного антихолестатического эффектов.
GÖRSEL SANATLARDA İRONİ VE TOPLUMSAL FARKINDALIK OLARAK ISAAC CORDAL’IN HEYKELLERİNDE İRONİ ETKİSİ İLE MEKÂN KULLANIMI
Authors: YILDIZ İLDEN Serap , BOSTANCI Emine
Published: July 2022

Geçmişten günümüze, sanatçılar dünyayı, dünyada yaşanılan olay ve durumları çalışmalarına aktarırken ironiden yararlandıkları görülmektedir. Sanatçıların dış dünyayı yorumlarken, eleştirel tavırlarının ürünü olarak ortaya çıkmış olan ironi olgusu, sanatçının eserinde sanatsal bir ifade aracı olmaktan daha çok, kendisinin hayata bakış açısını ve hayata karşı duruşunu içermektedir. İçinde yaşanılan anın teknolojik, siyasal, kültürel ya da toplumsal her türlü problemine, var olan fakat görmezden gelinen sorunlarına eleştirel, hicvedici veya farkındalığın arttırılması amacıyla sanat eserlerinde kendine yer bulan ironi sanatçı bireyin duyarlılığının da bir ifadesidir. Literatür araştırması ve görsel araştırma yöntemleri kullanılarak hazırlanan bu makalede, görsel sanatlarda ironi kavramının kullanımı örneklerle açıklanmıştır. Bununla birlikte makaleye konu olan İsaac Cordal’ın heykellerinin, yerleştirildiği mekân ile olan bağı, izleyiciye vermek istediği mesajları ve bunu sağlarken de kullanmış olduğu ironi dilinin, çalışmalarına olan etkisinin analizi yapılmıştır.
VAKSINASI COVID-19 MERUPAKAN HAK ATAUKAH KEWAJIBAN BAGI MASYARAKAT
Authors: Putri Farida Danas , Mahyani Ahmad
Published: July 2022

Coronavirus Disease 2019 atau disebut dengan Covid-19 pertama ditemukan di China dan menjalar di seluruh negara di dunia. Indonesia memasuki masa kritis Pandemi Covid-19 yang berdampak pada seluruh sector. WHO telah menetapkan Status Kedaruratan bagi Negara yang telah terpapar Virus Corona ini, begitupun Indonesia. Salah satu pencegahan Virus Corona ini yaitu dengan pengurangan aktivitas diluar rumah serta berjaga jarak antar manusia. Oleh karena itu, mulai dikenal dengan kebijakan Work From Home atau WFH yang mewajibkan segala aktivitas kantor ataupun sekolah dilaksanakan di dalam Rumah atau disebut dengan Karantina. Selain itu, Pemerintah telah membentuk peraturan mengenai vaksinasi dengan tujuan untuk mengatasi meningkatnya pasien Covid. Penelitian ini bersifat normative yang mengkaji Peraturan Menteri Keehatan mengenai Kegiatan Vaksinasi dan mengenai Pandemi Covid-19.
Re-Actualization of the Community Economy Based on Mutualism and Brotherhood Post-Covid-19 in Digital Economic Transactions
Authors:   Universitas Pasundan, Indonesia, Ruslina Elli , Rastuti Tuti , Sjam Zakki Abdilah
Published: July 2022

Even though the Covid-19 outbreak caused anxiety, it must be interpreted as having brought positive things to economic life. One of them is the emergence of Micro, Small and Medium Enterprises (UKKM) whose business activities are facilitated by information technology. The business relationships that have been built are characterized by family values, mutual cooperation values, and efforts to deal with the epidemic period, as well as being forward-looking after the outbreak ends. This social phenomenon is to actualize the people's economy in digital economic transactions. This study assumes a people's economy paradigm based on mutualism and the principle of kinship in digital economic transactions. The paradigm of economic development based on the values of local wisdom and Indonesianness is a new hope for the people's economy in realizing the constitutional mandate that prioritizes the interests of the people. The role of technology in the economy during the Covid-19 era is very large, having an impact on efficiency and effectiveness in meeting the economic needs of the community. Based on this, it is necessary to conduct a legal study of the actualization of the people's economy based on mutualism and the principle of kinship as an economic recovery post-covid-19. The purpose of the research is to examine the legal basis for the People's Economy on community economic activities based on the post-covid-19 digital economy. The research method uses secondary data, in the form of legal documents on laws and regulations in the economic field, various research results from legal and economic experts and field data in the form of interviews and observations. The data were analyzed qualitatively juridically, through legal interpretation, harmonization and synchronization of laws. The results of the study show that, the concept of a populist economy is actualized in community economic transactions based on post-covid-19 digital economic technology; Mutualism and familial values can be used as a legal basis in the paradigm of constitutional national economic development.
Post-traumatic stress disorder among university students in the Vietnam’s fourth COVID-19 wave
Authors: Nguyen Nguyen Thi Tuong Vi , Nguyen Nguyen Tan Thach , Tran Tran Thi Bach Truc , Bui Bui Minh Triet , Le Le Tho Minh Hieu , Le Le Minh Tu Phan , Le Hoang Thi Nam Giang
Published: July 2022

Since March 2020, the COVID-19 pandemic has become a global concern, affecting students' mental health. This study aims to explore the prevalence of post-traumatic stress disorder (PTSD), and sleep disturbance among Vietnamese students during the fourth COVID-19 wave. An online survey was performed with a questionnaire based on the Impact of Event Scale-Revised scale (IES-R). A total of 302 students were included in the study, in which there are 11.3% had PTSD. The prevalence of PTSD in female was higher than in male (p=0.006) and students who were fear of vaccine’s side effects had five times higher likelihood of PTSD compared to those who were not (p=0.009). In addition, changes in bedtime and wake-up times were associated with increased odds of PTSD in students (Adjusted Odds Ratios: 3.42, 95% Confidence Intervals: 1.90 to 6.16). The results emphasize the high prevalence of PTSD among students, which could have short- and long-term mental health impacts.
AES algorithm to find privacy-preserved item on cloud storage data
Authors: Hussain Shafiq
Published: July 2022

Frequent itemset mining, which is the essential operation in association rule mining, is one of the most widelyused data mining techniques on massive datasets nowadays. With the dramatic increase on the scale of datasetscollected and stored with cloud services in recent years, it is promising to carry this computation-intensivemining process in the cloud. Amount of work also transferred the approximate mining computation into theexact computation, where such methods not only improve the accuracy also aim to enhance the efficiency.However, while mining data stored on public clouds, it inevitably introduces privacy concerns on sensitivedatasets.
A SYSTEMATIC REVIEW ON PHOTOTHERMAL RADIOMETRY EFFECTIVENESS AND MODULATED LUMINESCENCE
Authors: Hussain Shafiq
Published: July 2022

Early dental disease is not diagnosed by traditional methods, so it is essential for the development of nonpreventive and non-contact methods. Photo-thermal radiometry and modulated luminescence (PTR-LUM) is asensitive non-invasive technique for the initial identification of caries participants. Evaluating the effect of PTRLUM as a non-invasive technique in the identification of caries. Electronic literature was searched using the termsPubMed, Science Direct, Wiley Online Library, National Institutes of Health, PubMed Central-National Center forBiotechnology Information, MeSH-PTR-LUM, Dental Carries and Carries Detection. 125 articles were obtained and119 articles were reviewed. In terms of eligibility, 16 full text articles were reviewed and a total of 7 articles wereselected for this systematic review, each meeting the inclusion criteria, and the results of this article werereviewed. This systematic literature review was presented in accordance with the PRISMA guidelines. Sevenrandomized controlled trials were included in the review process. The seven subjects in this review examined theeffectiveness of PTR-LUM in identifying dental diseases. Six out of seven articles confirm that PTR-LUM is effectivein identifying and controlling dental diseases. PTR-LUM has been shown to be effective in diagnosing dentaldiseases. It is a sensitive and reliable complementary non-invasive dentist for identifying and monitoring dentalcaries
Use of image processing to find leave dataset for agriculatural products
Authors: Hussain Shafiq
Published: July 2022

Plant diseases are one of the main causes of declining quality and quantity of agricultural products. Farmers havemany problems with identifying and controlling plant diseases. Therefore, it is important to diagnose cropdiseases at an early stage so that farmers can take appropriate and timely action to prevent future losses. Thestudy focuses on a plant disease identification approach based on image processing and machine learning. In thisproject, we will create a tool to help farmers identify plant diseases by taking a snapshot of a leaf. A set of systemalgorithms can detect leaf disease. The input image provided by the system user goes through several imageprocessing steps to diagnose the disease.
LINGUISTIC ESSENCE OF THE TRANSLATION PROCESS AND STAGES// ACADEMY JOURNAL ISSN 2733-0923, no. 1(19) (April 20, 2022)/ Chief Editor V. Klevtsov /Open European Academy of Public Sciences : Tallinn, Estonia, 2022 - P. 39-45.
Authors: Serikbayeva Ulzhamilya Bibatyrovna
Published: July 2022

To date, there is no universal translation model that would show all types of translation and explain the translation process. Perhaps one of the most well-known in the theory of translation is the definition of V.N.Komissarov, where, when studying the translation process, it is necessary to find out what the linguistic essence of this process is, the equivalence of translation to the original; what types of semantic relations are theoretically possible and how they are actually established when translating between texts of two languages. Comparing the content of the original and the translation, clarifying the concept of the content of the text, describing the structure of this content and the importance of its components to preserve them during translation.
Use of Time Stamps for Preserving Cloud Computing Data on Storage Stage
Authors: Hussain Shafiq
Published: July 2022

In this paper, we enhance the existing IM- DSSE protocol with a more secured time stamp protocol to have asecure data sharing protocol in Cloud and reduce the privacy risks involved in the system. This systemproposes a dynamic key that an adversary/attacker cannot able to predict/crack it. The dynamic Secret key isgenerated using the Time Stamp protocol. Only the approved party has the authority on having an encryptedsecret key which is generated using our proposed time stamp protocol of the client for cloud storage andupdates under the encrypted state in each time duration. An adversary cannot forge any authenticate in anyperiod even if it gets the decryption secret key by attacking the client.
Pore-scale imaging of hydrogen displacement and trapping in porous media
Authors: Thaysen Eike , Butler Ian , Hassanpouryouzband Aliakbar , Freitas Damien , Alvarez-Borges Fernando , Krevor Sam , Heinemann Niklas , Atwood Robert , Edlmann Katriona
Published: July 2022

Hydrogen can act as an energy store to balance supply and demand in the renewable energy sector. Hydrogen storage in subsurface porous media could deliver high storage capacities but the volume of recoverable hydrogen is unknown. We imaged the displacement and capillary trapping of hydrogen by brine in a Clashach sandstone cylinder at 2-7 MPa pore fluid pressure using X-ray computed microtomography. Hydrogen saturation obtained during drainage at capillary numbers of <10-7 was ~50% of the pore volume and independent of the injection pressure. Fluid configuration in the pore space was indicative of a water wetting system at all conditions. Capillary trapping of hydrogen via snap-off during secondary imbibition at a capillary number of 2.4x10-6 systematically increased with pressure, 20%, 24% and 43% of the initial hydrogen trapped at 2, 5 and 7 MPa, respectively. Injection of brine at increasing capillary numbers up to 9.4x10-6 reduced capillary trapping. Based on these results, we recommend more shallow, lower pressure sites for future hydrogen storage operations in porous media.
The Effects of Self-enactable Techniques on SDT Constructs Expert Study
Authors: Knittle Keegan Phillip , Fidrich Christin , Hankonen Nelli
Published: July 2022

While a large body of research on Self-Determination Theory (SDT) has identified characteristics of social environments that are conducive to optimal motivation, research has scarcely considered what individuals might themselves do to optimize motivation. Using the compendium of self-enactable techniques, this expert opinion study aimed to identify conceptual linkages between 123 self-enactable techniques and nine core SDT constructs. International scholars (n=67) judged a block-randomized subset of 30-40 self-enactable techniques for their likely impacts on SDT constructs. Theoretically plausible linkages between self-enactable techniques and SDT constructs are visualized as a network. The techniques Brainstorm options, Goal integration, Support others, Find meaning in target behavior, Associate identity with changed behavior, Valued self-identity, and Emphasize autonomy were adjudged as having potential beneficial impacts on five or more SDT constructs. Interventions requiring participant engagement, for example self-management or lifestyle counseling, will benefit from a better understanding of motivation self-management.
Sensory Processing Patterns Predict Problem Behaviours in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder
Authors: Schulz Samantha , Kelley Elizabeth , Anagnostou Evdokia , Nicolson Robert , Georgiades Stelios , Crosbie Jennifer , Schachar Russell , Ayab Muhammad , Stevenson Ryan A
Published: July 2022

Objectives: Sensory processing is the ability to discern and understand information from one’s sensory organs. Understanding sensory processing patterns in different clinical groups could elicit evidence that sensory processing patterns are a transdiagnostic mechanism that is important to understand in neurodevelopmental disorders. Furthermore, there is little evidence of how sensory processing patterns relate to behaviours, such as attention, social, and mood difficulties in autism and ADHD. The goals of this study were to directly compare sensory processing patterns in autism, ADHD, and typical development and to explore the association between sensory processing and behavioural outcomes. Methods: Data were collected through the Province of Ontario Neurodevelopmental Network. The parents of 805 children with typical development, ADHD, or ASD completed measures of sensory processing and behavioural outcomes with the Short Sensory Profile and the Childhood Behaviour Checklist, respectively. Sensory processing was compared across groups and regression analyses were conducted to determine if behavioral patterns could be predicted by sensory processing patterns in the clinical sample. Results: Overall, the results identified significant differences in sensory processing patterns between the diagnosed and undiagnosed participants. Autism and ADHD differed on all Sensory Profile subscales except Auditory Filtering and Under-Responsivity/Sensory Seeking. All behavioural outcomes were predicted by sensory processing patterns over and above the variance accounted for by diagnostic group, suggesting that understanding sensory processing patterns is an important piece of a comprehensive understanding of the behavioural patterns observed across multiple clinical populations. Conclusions: There is evidence that sensory processing is different in ASD and ADHD but that specific patterns of sensory processing are related to behavioural outcomes in both disorders. Better understanding sensory processing as a mechanism for behaviour can help to identify simple interventions across neurodevelopmental disorders.
De la teoría a la práctica: el emprendimiento en Ecuador en época de COVID 19.
Authors: López Galo , Rivera Jairo
Published: July 2022

El emprendimiento en el mundo es un proceso sistémico importante que dinamiza la economía y genera fuentes de empleo. En el Ecuador existe un alto espíritu emprendedor que combina motivaciones de oportunidad y necesidad, que se ha visto afectado por la pandemia sanitaria que vive el mundo. En este contexto, el objetivo de esta investigación es analizar el emprendimiento a través de un caso práctico y sus particularidades en época de COVID 19. La metodología es mixta, fundamentada en los Espacios Vacíos, combinando un análisis cuantitativo basado en datos primarios y un análisis cualitativo de fuentes de información secundaria. Entre los principales resultados se destaca que el emprendimiento es el resultado de la combinación de varios ingredientes que, adecuadamente combinados, como en el caso práctico, pueden generar negocios sostenibles en el tiempo.
Síndrome Multisistémico Inflamatorio Pediátrico temporalmente asociado a SARS-CoV-2: un nuevo reto a la luz de la evidencia.
Authors: Hernández José , Sanguinetty Nelson , Quintero Beatriz , Mavárez Alibeth
Published: July 2022

En los niños el curso de la COVID-19 es benigno por su baja susceptibilidad comparados con adultos, aunque no está claro por qué la mayoría son asintomáticos; además de la presencia de una nueva afección, similar a la Enfermedad de Kawasaki. El objetivo de esta investigación fue presentar de forma organizada, una revisión sistemática con la información existente sobre el Síndrome Multisistémico Inflamatorio Pediátrico temporalmente asociado a SARS-CoV-2. Para ello se utilizaron los principales buscadores médicos de internet; basados en criterios de selección estrictos se buscó aclarar la interrogante: ¿Es necesario la unificación de criterios diagnósticos, clasificación y manejo para esta nueva entidad nosológica, que permita la implementación de protocolos adaptados a la luz de la evidencia existente? Muchos niños con PIMS-TS, mejoran con atención médica, otros empeoran rápidamente peligrando su vida, se sugiere que SARS-CoV-2 es un factor inmunomodulador, pudiendo ser modificado por factores ambientales y relacionados al agente etiológico. Las pruebas complementarias más empleadas son : ecocardiografía, hemograma, marcadores de inflamación, marcadores de daño miocárdico y PCR y serología para el SARS-CoV-2. La naturaleza multifacética de la enfermedad amerita un manejo multiespecializado en centros médicos de alta complejidad, considerando la individualidad de los casos. El tratamiento, evolución intrahospitalaria y seguimiento dependerá de los casos.
Inseguridad alimentaria en hogares ecuatorianos durante el confinamiento por COVID-19
Authors: Robayo Carmen Viteri , Iza Patricia Iza , Mejía Carlos Moreno
Published: July 2022

La seguridad alimentaria se ha visto afectada a causa de la pandemia por COVID-19. Siendo el objetivo de esta investigación, evaluar el acceso a alimentos suficientes, seguros y nutritivos en la población de Ecuador. Para ello se aplicó la Escala Latinoamericana y del Caribe, validada con el estadístico alfa de Cronbach (?=0,884). Se receptó 478 encuestas vía on-line, que fueron respondidas previo un consentimiento informado. Los datos se analizaron desde una estadística descriptiva e inferencial empleando el paquete estadístico SPSS versión 22. Como resultado del estudio, el 77,3% de hogares presentó inseguridad alimentaria leve y moderada, frente al 13,2% con inseguridad severa. Una de las principales preocupaciones en el 73,5% de hogares fue el quedarse sin alimentos. El 39,9% de hogares mantienen una alimentación poco variada, sin alimentos saludables y nutritivos en su dieta. Por otro lado, el 25,2% de adultos y 11,9% de menores de 18 años omiten alguna comida durante el día (desayuno, almuerzo, merienda). Preocupa que algún miembro del hogar, joven o adulto, (entre el 20 y 30%) come menos de lo que considera que debía comer, sintiendo hambre. En cuanto a género son las mujeres las que registran mayor inseguridad alimentaria, sin diferencia estadística significativa; así mismo, quienes viven en zonas urbanas muestran mayor inseguridad con respecto a los que viven en zonas rurales. La seguridad alimentaria será uno de los retos que los gobiernos locales deban enfrentar para salvaguardad la salud de la población, siendo la agricultura una de las actividades que se debe priorizar.
¿Se pueden prevenir las pandemias? Epidemiología basada en aguas residuales
Authors: Hernández Elizabeth Velástegui , Lalaleo Liliana , Cáceres William Calero
Published: July 2022

En el presente artículo de opinión, se analiza el potencial del estudio de aguas residuales como predictor epidemiológico de futuras emergencias de salud pública. La detección de SARS-CoV-2 de forma preliminar a la manifestación de brotes clínicos en aguas residuales urbanas; y, la correlación entre determinados marcadores biológicos con características intrínsecas de la población nos permite elucidar que su análisis podría ser utilizado como alerta temprana del aparecimiento de futuras emergencias de salud pública. De acuerdo con diversas predicciones, la humanidad enfrentará varias crisis sanitarias en este siglo derivadas del cambio climático y la contaminación antropogénica. La aplicación de herramientas ómicas en el análisis de aguas residuales permite detectar modificaciones en los patrones de microorganismos patógenos, por ende, es necesaria la optimización de metodologías que permitan aplicar estas tecnologías como herramientas epidemiológicas a nivel global.
EDITORIAL DEL VOL. 14 INVESTIGACION Y DESARROLLO I+D Enero-Junio 2021
Authors: Valdez Duffau(PhD) Mathias , (PhD) Yenddy Carrero , (PhD) Alicia Zavala
Published: July 2022

John Paúl Reyes Vasquez (Mg)- Director Dirección de Investigación y Desarollo, UTA

Mathias Exequiel Valdez Duffau(PhD)-Editor - Revista Investigación y Desarrollo, UTA

Yenddy Carrero Castillo -Coordinadora Volumen 14

Alicia Marifernanda Zavala Calahorrano-Asistente editorial

Revista de Divulgación Científica

INVESTIGACIÓN Y DESARROLLO I+D

Volúmen 14, Número 1

P-ISSN: 1390-5546

E-ISSN: 2361-2557

revista.dide@uta.edu.ec

Publicado: 2021-07-31
EXTRACTOS DE PLANTAS MICROENCAPSULADAS CON POTENCIAL ACTIVIDAD ANTIVIRAL: UNA REVISION GENERAL
Authors: Rodriguez Conterón Oscar , López Hernández Orestes
Published: July 2022

El uso de compuestos activos de plantas ha generado una alternativa natural en torno a las afecciones que involucran la salud humana. Un extracto de plantas es una mezcla compleja de moléculas bioactivas que presenta propiedad antioxidante, antiviral, antimicrobiana, antiparasitaria, entre otras. A pesar que un reto prominente para el uso de extractos herbales es el uso de solventes orgánicos pues dificultan su formulación y administración directa a personas, esto podría ser solucionado ya que investigaciones recientes señalan a la microencapsulación como una tecnología alentadora en la administración de fitofármacos.

La presente revisión se centró en treinta y dos estudios publicados en idioma Inglés y Español de algunas investigaciones relevantes realizadas mayoritariamente en los últimos diez años que señalaron la importancia de las plantas en el área farmacéutica, principios activos de plantas con actividad antiviral, formulaciones de extractos de plantas, además del uso de la microencapsulación para su presentación final y aseguramiento en su biodisponibilidad, proporcionando una descripción general en la investigación global sobre el secado de extractos herbales con potencial actividad antiviral.
COVID-19 EN EL PACIENTE PEDIÁTRICO. ¿ES IGUAL AL ADULTO? UNA REVISIÓN BIBLIOGRÁFICA
Authors: Philco Priscila , Jordán Paola , Navas Luis , Jimenez Gabriel
Published: July 2022

La enfermedad por coronavirus-2019 (COVID-19) que apareció en Wuhan, China, se esparció por el mundo, afectando a distintos grupos poblacionales; los niños, mostraron un comportamiento clínico diferente al adulto frente a la infección. La investigación se desarrolló con el objetivo de identificar las particularidades del contagio de la enfermedad en los niños, además de precisar un abordaje integral para este grupo etario. Se realizó una búsqueda sistemática de la literatura científica acerca de la enfermedad enfocada en el paciente pediátrico en las principales bases de datos científicas, a través de descriptores controlados y sin restricción de idioma. La enfermedad COVID-19 provocada por el nuevo coronavirus causante del síndrome respiratorio agudo severo, dificultó en gran porcentaje el diagnóstico y tratamiento en niños y adolescentes por lo que los niños infectados tienen características clínicas, hallazgos de laboratorio e imágenes radiográficas distintas al cuadro del adulto. Siendo necesarios más estudios para una mejor comprensión del riesgo que conlleva la enfermedad en este sector de la población.
ALTA TASA DE MORTALIDAD ENTRE PACIENTES MAYORES CON COVID-19 EN ECUADOR. ESTUDIO DE CASO EN RETROSPECTIVA (MARZO 15, 2020 – ABRIL 15, 2020)
Authors: Mayorga  Ramos Arianna
Published: July 2022

Ecuador registró un creciente número de casos y muertes relacionadas con COVID-19 durante un periodo extendido de tiempo. Este estudio de caso pretende evaluar los datos epidemiológicos reportados por el Ministerio de Salud Pública del Ecuador durante un periodo limitado de tiempo (Marzo 15 – Abril 15). Se enfoca en diferenciar la tasa de mortalidad entre grupos de diferentes edades. La tasa de letalidad fue calculada con un resultado promedio de 4,94% de mortalidad para pacientes positivos de COVID-19 de todas las edades al final del periodo de recolección de datos. También indicó que los pacientes de ‘65 años o más’ tuvieron la Tasa de Letalidad más alta (16,63%) seguidos de los pacientes con edades entre ‘50-64 años’ (7,37%). La tasa más baja fue de 0% para pacientes con edades entre 5-19 años. Por lo tanto, indicando una alta tasa de mortalidad entre pacientes de edad avanzada. La Tasa de Letalidad encontrada en pacientes ecuatorianos ancianos también parecen ser ligeramente mayor a las tasas estimadas en otros países. Presencia de comorbilidades relacionadas a la edad podrían ser responsables del incremento en mortalidad en este grupo de edad. Comportamientos sociales, económicos y culturales relacionados con etnicidad (Latinoamericana) también podrían facilitar la propagación del virus ente la población vulnerable, por lo tanto, incrementando la mortalidad.
Esfuerzo de pre-consolidación basado en la medición de Vs en suelos lacustres
Authors: Fernández-Lavín Alfonso , Chamorro-Zurita Claudia
Published: July 2022

Para realizar un análisis esfuerzo-deformación en un suelo saturado, es indispensable conocer el esfuerzo de pre-consolidación. Por esta razón, en los últimos 80 años se han propuesto una serie de criterios que permiten evaluar esta variable en ensayos de consolidación unidimensional. Además, muchos investigadores han equipado con cristales piezoeléctricos sus consolidómetros para poder relacionar las propiedades mecánicas de los suelos con el cambio de rigidez elástica producida por el cambio del estado de esfuerzo. Dentro de la información adquirida con la medición de ondas sísmicas es posible observar de una manera indirecta el cambio de la estructura del suelo durante una prueba de consolidación e incluso poder evaluar el esfuerzo de pre-consolidación. En esta investigación se analizan datos provenientes de ensayos de consolidación efectuados sobre muestras inalteradas de suelo lacustre blando en los que se han medido la velocidad de onda cortante para estimar el esfuerzo de pre-consolidación. Los resultados obtenidos se compararon con algunos criterios presentados en la bibliografía especializada observándose muy buena relación especialmente con los métodos visuales de Casagrande y de Pacheco-Silva. Además, la interpretación de los tiempos de arribo de la onda cortante se realiza utilizando un enfoque basado en la identificación del primer pico dentro un análisis tiempo-escala-coeficiente basado en el marco teórico de la transformada wavelet.
Artículo recibido: 20 de agosto de 2021
Artículo aceptado: 11 de noviembre de 2021
Desarrollo de un software para el diseño de conexiones precalificadas conforme a la normativa ANSI/AISC 358-16
Authors: Vega-Ilaquiche Alex , Suquillo-Ronquillo Betzabeth , Chacón-Sánchez Juan
Published: July 2022

Las conexiones precalificadas viga-columna desempeñan un rol crítico en el comportamiento de las estructuras de acero; de ellas depende el adecuado comportamiento del sistema estructural seleccionado pues permiten al sistema disipar energía en eventos sísmicos por medio de deformaciones inelásticas, por lo cual en el presente artículo se muestra la implementación numérica de un software libre SEDE CONNECTION (Seismic Design Connection), de uso educativo para el análisis y diseño de tres tipos de conexiones a momento: sección de viga reducida (RBS), placa de extremo extendida de cuatro pernos sin rigidizadores (BUEEP 4E) y placa apernada al ala (BFP) de acuerdo a lineamientos establecidos por la norma AISC 358-16. Uno de los objetivos de esta implementación numérica es obtener resultados de forma rápida y segura reduciendo tiempo de análisis y desgaste computacional. Este software fue validado cuantitativamente mediante una comparación de resultados obtenidos manualmente, obteniendo una diferencia bastante baja, verificando así que los valores obtenidos son fiables para verificar y/o diseñar conexiones precalificadas.
Artículo recibido: 26 de septiembre de 2021
Artículo aceptado: 11 de noviembre de 2021
Desempeño de edificios de acero con masas de agua en movimiento concentradas en azotea, durante sismos intensos
Authors: Medina-Robalino Christian , Medina-Robalino Santiago
Published: July 2022

El análisis de masas de agua en movimiento ubicadas en la azotea de edificaciones es un tema relevante en la ingeniería estructural, pues a menudo son causantes de daños severos durante eventos sísmicos intensos. Usualmente, este efecto es ignorado en el diseño sismorresistente. En el presente estudio, se abordó este problema a través del análisis dinámico no lineal (ADNL) de una estructura de marcos de acero de 15 pisos, sometida a un set de 7 registros de sismos de subducción chilenos escalados al espectro de diseño de NCh433. La edificación se representó mediante un modelo numérico bidimensional en el software OpenSEES, mientras que se utilizó el modelo desarrollado por Housner y la norma ACI350.3 a fin de representar el comportamiento hidrostático e hidrodinámico del agua en reposo y en movimiento respectivamente. Los resultados obtenidos muestran que además de modificarse los parámetros modales, el efecto del oleaje incrementa la demanda aceleración máxima de techo en un 30% y en un 10% los máximos desplazamientos y derivas de piso. Asimismo, la deformación residual obtenida al final del evento se incrementa considerablemente (63%), alcanzándose un mayor grado de daño estructural reflejado en la incursión inelástica de los elementos.
Artículo recibido: 09/09/2021
Artículo aceptado: 11/11/2021