bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient Attitude towards Videodermatoscopy for the Detection of Skin Cancer: A Cross-Sectional Study
Authors: Steeb Theresa , Wessely Anja , Niesert Anne-Charlotte , Ruzicka Thomas , von Braunmühl Tanja , Berking Carola , Heppt Markus Vincent
Published: April 2019

Background: Videodermatoscopy (VD) is a useful device for supporting dermatologists in the distinction between benign and malignant lesions. However, only few patients have access to VD in daily practice. Objectives: To investigate patient attitudes towards VD. Method: A cross-sectional study was conducted between May and June 2018. Patients were asked to complete a self-administered questionnaire on the popularity of VD. Descriptive analysis was performed including contingency tables and χ2 tests to investigate associations between sociodemographic data and the popularity of VD. Results: A total of 61.2% (123/201) of the patients had not heard of VD at the time of assessment or were unsure. Of the 38.8% of patients (78/201) who already knew of VD, 64.1% (50/78) reported that they had already been investigated by VD; 57.5% (111/193) were willing to pay an extra fee for VD. A high level of education and private insurance status had a statistically significant association with the popularity of VD (p = 0.036 and p = 0.026, respectively). Conclusions: There was a strong information deficit, especially in patients with lower education and statutory health insurance. Nevertheless, the willingness to pay an extra fee for a VD-assisted skin examination was high. Dermatologists should actively offer and inform their patients about VD when performing skin cancer screening.
Lepeophtheirus salmonis (Copepoda: Caligidae) on farmed salmon in Ireland
Authors: Jackson David , Hassett Daniel , Deady Sandra , Leahy Yvonne
Published: April 2019

The investigation of specific characteristics of Lepeophtheirus salmonis populations on farmed salmon was made possible by the examination of the parasite infestation parameters of regular non destructive samples taken for up to six years in five bays. Perennial persistence of seasonal patterns of infestation as exhibited by intensity, prevalence and abundance was examined. Site specific characteristics were detected which appeared to be independent of inter-annual variations. Seasonal variations in individual lice size and fecundity, and temporal variation in population dynamics on the farmed fish in the five bays are considered in the context of the not inconsiderable changes in husbandry and lice control practices which have been introduced in the industry over the six year period.
The colleteric glands in Sacculinidae (Crustacea, Cirripedia, Rhizocephala): an ultrastructural study of ovisac secretion
Authors: Lange Sven
Published: April 2019

Ovisac secretion by the paired colleteric glands of Sacculina carcini and Heterosaccus dollfusi (Rhizocephala, Sacculinida) was documented and studied at the ultrastructural level. Preparatory to oviposition, the epithelium of each colleteric gland secretes one branched, elastic, transparent ovisac. The ovisac wall consists of a reticulated inner zone, secreted first, and a dense outer zone. After secretion, the ovisac detaches from most of the secretory epithelium but remains anchored proximally in the gland until oviposition ends. The exterior ovisac surface is predominantly smooth and impervious. Proximally, however, the surface is irregular and perforated. During oviposition the eggs enter the paired ovisacs, forcing the ovisacs through the ovipores into the maternal mantle cavity. Simultaneously the ovisac volume increases approximately 100 times. The resulting paired egg masses, branched like the ovisacs, are brooded and ventilated in the mantle cavity. Ovisacs prevent that developing embryos are lost prematurely with the ventilation current. Within two days the egg masses solidify and attach to retinacula in the mantle cavity cuticle. The ovisacs, now probably obsolete, are no longer discernible. The literature on colleteric gland morphology implies that ovisacs are secreted by all Sacculinidae and perhaps other Rhizocephala with colleteric glands. Similarities in both the secretory process and morphology suggest homology between the colleteric glands of Sacculinidae and the oviducal glands of Thoracica (Cirripedia) and between their products.
The clavobranchialis musculature in sarcopterygian fishes, and contribution to osteichthyan feeding and respiration
Authors: Johanson Zerina
Published: April 2019

Various fossil lungfish taxa preserve distinct depressions on the smooth postbranchial lamina of the dermal pectoral girdle. These depressions are largely unknown in other sarcopterygian fishes, but are present in the rhizodont sarcopterygian Strepsodus. Comparisons with extant actinopterygian fishes suggest these depressions mark the point of origin for the clavobranchialis musculature, extending anterodorsally into the gill chamber to insert on the ventral surface of the ceratobranchial(s). Studios examining feeding and respiratory mechanisms of bony fishes (Osteichthyes) have emphasised the role of mandibular depression in generating negative pressures within the oral cavity to draw in water/air/food via suction. However, phylogenetically basal actinopterygians, fossil lungfish and other fossil sarcopterygians (such as Strepsodus) lack the apomorphies that increase suction among bony fishes. In these taxa the clavobranchialis muscles may serve to augment this negative pressure by retracting the ceratobranchials and increasing the size of the oral/ oropharyngeal cavity. A comparable action is performed by the chondrichthyan coracobranchiales muscles, particularly during feeding, and the function of these ventral gill arch muscles is likely to be a synapomorphy of jawed vertebrates (Gnathostomata). This musculature is absent from jawless vertebrates such as the Osteostraci.
Morphometric analysis of extant Nephrops norvegicus (Linné, 1758) and Solenocera membranacea (Risso, 1826) applied to systematic palaeontology of fossil decapod crustaceans
Authors: Damiano Giuseppina , Garassino Alessandro , Scali Stefano , Teruzzi Giorgio
Published: April 2019

The study of fossil decapods have shown the need for reliable statistics to document the value of the characters considered. Morphometric data, however, are usually absent in scientific papers on living decapod crustaceans since neontological systematists normally analyze internal organs and tissues not available in fossils. A series of morphometric data for two extant species have been processed statistically in order to obtain numerical models that could be applied to fossil species showing morphological affinities.
Early Cretaceous arthropods from plattenkalk facies in Mexico
Authors: Vega F.J. , Garcia-Barrera P. , Coutiño M. , Nyborg T. , Cifuentes-Ruiz P. , González-Rodríguez K. , Martens A. , Delgado C.R. , Carbot G.
Published: April 2019

Several well-preserved arthropod faunas have been studied in Mexico during the past few years. The purpose of the present note is to outline advances in the study of these arthropods and of their paleoenvironmental implications, from four localities. The age for these localities ranges from the Early to the Late Cretaceous. At most of these localities lithographic limestones crop out, with fish remains representing the most attractive element of study. However, arthropods constitute a very important tool for reconstructing paleoenvironment (marine crustaceans, freshwater and terrestrial insects and arachnids). Detailed studies of these assemblages will aid in our understanding of ancient coastal dynamics and the paleoecology of these unique environments.
Remediating Kalimán: Digital Evolutions of Eugenic Agents
Authors: Gutiérrez Itzayana
Published: April 2019

Kalimán is a Mexican superhero that has circulated Orientalist eugenic values for over fifty years across Latin America. Although Indian, and wearing traditional Indian subcontinental clothing, distinguishable only by a jewel-encased “K” on his turban, Kalimán is a muscular, blue-eyed, and white character. He was created in 1963 as the main protagonist of a radio series that spawned a comic magazine in 1965, two films in 1972 and 1976, and animations and video games in the early 2010s, in a massive process of remediation that has guaranteed a solid mark in the cultural patrimony of the Americas. Since Kalimán incarnates impulses of punishment and desire over racially contaminated brown and black characters, his undisturbed, easy-to-access, and enduring presence provides evidence of deeply ingrained anti-Asian violence in Latin American popular culture, as well as the urge to develop a critical look at graphic violence traditions which continue to be treasured.
Dissenting Voices: Challenging the Colonial System
Authors: Janse Maartje , Hoek Anne-Lot
Published: April 2019

This publication emerges from a process of co-creation in which
historian Maartje Janse and research journalist Anne-Lot Hoek challenge the
dominant national narrative about the colonial experience in the Dutch East
Indies (present-day Indonesia). In combining journalistic and academic writing
with musical performance by musician Ernst Jansz they amplify the critical
voices that have spoken out against colonial injustice and that have long been
ignored in public and academic debate. Even though it is often suggested that
the mindset of people in the past prevented them from seeing what was wrong with
things we now find highly problematic, they argue that there was indeed a
tradition of colonial criticism in the Netherlands, one that included the voices
of many ‘forgotten critics’ whose lives and criticism are the subject of this
publication. The voices however were for a long time overlooked by Dutch
historians. The publication is organized around the biographies of several
critics (whose lives Janse and Hoek have published on before), the historical
debate afterwards and includes reflective videos and texts on the process of
co-creation.

Maartje Janse started the process by tracing the life history of an outspoken
nineteenth-century critic of the colonial system in the Dutch East Indies,
Willem Bosch. The authors argue that it was not self-evident how criticism of
colonial injustices should be voiced and that Bosch experimented with different
methods, including organizing one of the first Dutch pressure groups.

The story of Willem Bosch inspired Ernst Jansz, a Dutch musician with Indo roots,
to compose a song (‘De ballade van Sarina en Kromo’). It is an interpretation of
an old Malaysian ‘krontjong’ song, that Jansz transformed into a protest song
that reminds its listeners of protest songs of the 1960s and 1970s. Jansz, in
his lyrics, adds an indigenous perspective to this project. He performed the
song during the Voice4Thought festival in 2016, a gathering that aimed to
reflect upon migration and mobility in current times. Filmmaker Sjoerd Sijsma
made a video ‘pamplet’ in which the performance of Ernst Jansz, an interview
with Maartje Janse, and historical images from the colonial period have been
combined.

Anne-Lot Hoek connected Willem Bosch to a series of twentieth-century
anti-colonial critics such as Dutch Indies civil servant Siebe Lijftogt,
Indonesian nationalists Sutan Sjahrir, Rachmad Koesoemobroto, Dutch writer Rudy
Kousbroek and Indonesian activist Jeffry Pondaag. She argues that dissenting
voices have been underrepresented in the post-war debates on colonialism and its
legacy for decades, and that one of the main reasons is that the notion of the
objective historian was not effectively problematized for a long time.

http://dissentingvoices.bridginghumanities.com/
Communicative Strategies of Author’s Blog
Authors: Акаева Э. , Akaeva E. , Винокурова Т. , Vinokurova T.
Published: April 2019

Modern blogs are means of public influence. The authors analyze communicative strategies, stylistic and lexical means used by Deborrah Blum, journalist and blogger involved in environmental issues discussion. The range of means under consideration is wide due to extreme topical significance. Ecological problems are challenge of modern society and blog’s author attracts contemporaries attention to them. Discourse analysis and content analysis are dominant research methods. The author of the blog, having an expert status uses such communicative strategies as regulative, metacommunicative, informative and modal-evaluative. Informative and influential potential of blogs is caused both by topical acuteness and virtual communication participants feedback, their joint and collective authorship. Blog discourse emphasizes topical social issues. Contemporary blog is of both informative and evaluative character. Virtual communication depicts cognitive and mental patterns of the Internet communication typical participants in information epoch.
Metaphorical Representation of Migration in the US Media Discourse
Authors: Полонская О. , Polonskaya O.
Published: April 2019

This study focuses on the metaphorical features of migration representation in the American press. According to the cognitive approach on which our research is based, the metaphor is an important phenomenon in understanding the surrounding reality. The study of linguistic material and the description of metaphorical models allowed us to identify attitudes towards migrants at the present stage of development of American society. The analysis of conceptual metaphors was carried out by means of a continuous sample of electronic versions of the American media and made it possible to distinguish three main groups: metaphors that personify natural phenomena and natural disasters, military and commodity-thing metaphors. An analysis of the factual material suggests a negative stereotype associated with migrants in the minds of Americans.
BREVÍSSIMAS CONSIDERAÇÕES SOBRE LÍNGUAS BANTU; EM PARTICULAR, A LÍNGUA KIKONGO: MEMÓRIAS AFRO-BRASILEIRAS
Authors: Santana Tiganá
Published: April 2019

A língua kikongo, dentro do vasto mapa linguístico do continente africano, inclui-se no grupo bantu,  estudado, notadamente, por linguistas como Greenberg (1982), Nurse e Philippson (2014), Ngunga (2014), Castro (2005), etc. Apresentamos uma descrição básica do kikongo, a partir da gramática de Miguel Barroso Quiala, Longoka Kikongo. A memória da referida língua, que exerce importante influência sobre a cultura brasileira, chega-nos, nestes escritos, por meio do que é geralmente cantado no Candomblé de linhagem conhecida como Congo-Angola.
A evolução da mesóclise
Authors: Haffner Ildikó
Published: April 2019

The aim of the paper is to give an overview of the development of mesoclisis, a peculiar area of pronominal clitic placement. Mesoclisis is a particular instance of enclisis (Verb-clitic) when a clitic is placed inside a morphological word, surfacing in between the verbal root and the inflectional suffixes. Mesoclisis only appears with future and conditional forms of the verb, clearly showing the origins of the inflexion, namely the Vulgar Latin auxiliary, habere. In most Romance language the analytic future and conditional became synthetic at an early stage and could not be divided by a constituent (clitic) but in Old Spanish and Portuguese mesoclisis was still a preferred option. It was also natural for both Spanish and Portuguese authors to use the mesoclitic form in the 16th century. With the explosive growth of proclisis (clitic-Verb) in Spanish, mesoclisis became gradually unused and disappeared, whereas Portuguese preserved this archaic structure and it is still in use if there is no triggering condition in the sentence (negation, wh question, adverbs, etc.) Today they are in complementary distribution with enclisis and well defined rules set their use, it is the morphology of the verb that defines the choice.
Los grupos consonánticos /-n’r-/ y /-l’r-/ en el futuro : simple y en el condicional simple del castellano
Authors: Kispéter Mónika
Published: April 2019

The aim of this article is the investigation of certain Spanish conjugated verb forms in future tense and in conditional mode. These forms during the Middle Age had more verb stems; as opposed to this, in Modern Spanish only one of these stems is found. These forms are the result of the medieval Spanish speakers’ intent to avoid the “inconvenient” secondary consonantal groups /-n’r-/ and /-l’r-/ that had emerged as the consequence of syncope. Four different verb stems were e. g. in the case of the verb venir: (1) there is no change, so the secondary consonantal group is not dissolved (venré); (2) assimilation occurred, the /n/ assimilated to the /r/ (verré); (3) metathesis was produced, which means that the two sounds (verné); (4) there is an epenthesis, between the /n/ or the /l/ and the /r/ inserts a phoneme (vendré). The former case is the sonly applied one in Modern Spanish. The article attempts to explain why only this one form is used in the case of the verbs, although there are examples of the other phenomena in other Modern Spanish words. The article also gives explanation of the formation of these words. Furthermore, all four verb stems are examined from the point of view of its syllable structure, the universal sonority hierarchy ad morphology.
La imagen de América Latina en las letras húngaras y la presencia de la literatura húngara en América Latina : un esbozo
Authors: Tóth Éva
Published: April 2019

The author, who is a poet, editor, and literary translator is one of those who have done a lot to
make Latin American literature known in Hungary, and Hungarian literature known in Latin
America. The study gives a brief overview of some of the most important characteristics of this so far
little researched topic as well as provides some examples of the main representatives.
La Iglesia Católica cubana y el Estado en 1959 según la circular Vida Nueva
Authors: Horváth Emőke
Published: April 2019

The paper analyzes the relationship
between the Cuban government and the
Catholic Church after the victory of the Cuban
Revolution in 1959. The struggle of Fidel
Castro and his fellow rebels against the Batista
dictatorship was supported by a significant
number of priests and catholic faithfuls. Three
days after the victory of the Ejercito Rebelde, a
pastoral letter with the title of Vida Nueva
(New Life) was issued by Mons. Enrique Pérez
Serantes, the primate of Cuba. This letter is a
main source for the interpretation of the
Church and State relations at the beginning of
the political changes. The analysis of the letter
helps to understand the attitude of the Catholic
Church toward the new political system and it’s
leader, Fidel Castro. After the victory of the
revolution, despite the earlier promises, the new
Cuban State vigorously opposed the Catholic
Church. The new goverment began to weaken
its institutional system, and aspired to the
elimination of these institutions in some fields.
“Voces y espejos” de Espido Freire. Hacia una estética de la perversión en el relato especular
Authors: Rodriguez Samuel Rodriguez
Published: April 2019

Espido Freire (Bilbao, 1974) is one of the most interesting authors of contemporary Spanish literature. She has admitted on numerous occasions her preference for tales. “Voces y espejos” belonging to the storybook Juegos míos (2004), is offered as a paradigm of the obsessions that populate her work: the voices and mirrors as inducers of evil. The mise en abyme while splitting the narrator – widely studied by Lucien Dällenbach – permits the author to develop an alter ego what was so beloved by Borges and Cortázar. And here it aims at a hidden voice in us, which is subtle, barely perceptible, but always evil, which is intended to be reflected by the mirror dangerously. This story also presents the particularity of applying a double mise en abyme for its metaliterary character, what refers to the proper conception and reception of the story in a macabre triangle between the author, text and reader.
Catalunya i la Guerra de Successió d’Espanya : (1702-1714)
Authors: Alcoberro Agusti
Published: April 2019

The War of the Spanish Succession
affected the entire continent of Europe directly
or indirectly. Within the Spanish Monarchy,
Catalonia and the other states of the Crown of
Aragon sided with Archduke Charles of Austria
(Charles III), while Crown of Castile lent its
support to Duke Philip of Anjou (Philip V).
After the Peace of Utrecht, Catalonia
prolonged its resistance for 14 more months
under a republican government. At the end of
the war, the victors imposed repression, exile
and the end to the Catalan constitucions.
The Photocatalytic Activity of Zns-TiO2 on a Carbon Fiber Prepared by Chemical Bath Deposition
Authors: Rahmawati Fitria , Putri Fatmawati R. , Masykur Abu
Published: April 2019

This research prepared a TiO2, ZnS, and ZnS-TiO2film on a carbon fiber, to produce TiO2/C-fiber, ZnS-C-fiber, and ZnS-TiO2/C-fiber by Chemical Bath Deposition (CBD). Results show that TiO2/C-fiber consist of anatase at 2θ 25.3 o and 54.6 o, rutile at 2θ 43.5 o and a carbon characteristic peak at 2θ of 24.5 o. Meanwhile, the characteristic peaks of ZnS on ZnS-TiO2/C-fiber present at 2θ of 27.91 o and 54.58 o. TiO2/C-fiber has a band gap energy of 3.60 eV, the ZnS/C-fiber of 3.73 eV; when those two catalyst combine, the gap energy is 3.15 eV indicating the interface charge transfer between ZnS-TiO2. Photocatalytic treatment of an isopropanol solution with TiO2/C-fiber as a catalyst and under UV light radiation present results peaks at 222- 224 nm and 265 nm, indicating the electronic transition of acetone. Meanwhile, the isopropanol degradation with ZnS-TiO2/C-fiber produced a new peak at 234-237 nm. The Quantum Yield, QY, of ZnS-TiO2/C-fiber is 6.96 x 10-4, higher than TiO2/C-fiber, i.e., 0.42 x 10-4. It indicates that ZnS provides a significant role in the photocatalytic activity through a red shift of light response and decreasing electron-hole recombination.
The R.B.Q. (Rational, Behavioral and Quantified) Model
Authors: Challoumis Constantinos
Published: April 2019

[full article and abstract in English]

This paper is about the classic methods used in the analysis of economics. More precisely, the R.B.Q. (Rational, Behavioral, and Quantified) model is about rational economics and behavioral economic analysis in conjunction with the quantification procedure (Q.E. method). Therefore, in this work are submitted the most common methodological approaches used in economics including a form of their combination. What follows is a critical examination that extendedly scrutinizes the terminology of axiomatic methods. One of the aims of this paper to represent the special characteristics of rational economics in comparison to the case of behavioral economics. Then provided is an analysis wherein the issues relevant to this are represented, and on the basis of which the main differences between the two concepts are showed. Hence, the aim here is to show the crucial attributes of these concepts. This study also uses a quantification method to show the behavior of these two economic theories within their relation to one another, demonstrating a complete view of them in a single economic model.
A Simple Model for the Integration of Goods and the Capital Market with Unionized Labor Markets
Authors: Buccella Domenico
Published: April 2019

[full article and abstract in English]

The present work analyzes the effects of goods and capital market integration on welfare. In an imperfectly competitive industry with unionized labor, openness to competition via exports, the possibility of holding minority stakes into a rival company and undertaking Greenfield Foreign Direct Investment (FDI) exemplify product and capital market liberalization, respectively. Challenging the “lieu commune” that liberalization a priori improves the social welfare of an economy, making use of a game-theoretic approach, it is shown that a domestic government should design the appropriate interventions in product and capital markets depending on the precise pattern of economic integration.
Surface Enhanced Vibrational Spectroscopy of Proteins with
Plasmonic Nanoantenna Arrays
Authors: Adato Ronen , Yanik Ahmet A. , Amsden Jason J. , Kaplan David , Omenetto Fiorenzo , Hong Mi K. , Erramilli Shyamsunder , Altug Hatice
Published: April 2019

Infrared absorption spectroscopy is a powerful tool for structural and
functional studies of biomolecules. The technique enables direct access to
the vibrational fingerprints of molecular bonds in the mid-infrared spectral
region (3-20μm). Although intrinsic absorption cross-sections are nearly ten
orders of magnitude greater than corresponding Raman cross-sections, they
are still small in comparison with those of fluorescent molecules.
Sensitivity improvements are therefore required for the method to be
applicable to single molecule / molecular layer studies. In this work, we
demonstrate the use of lithographically patterned arrays of nanoantennas to
enhance the absorption signature of the protein amide-I and II backbone
vibrations. Strong absorption signals from monolayer thickness films are
obtained. By arranging ensembles of tailored antennas in specific lattices,
higher quality factor resonances and increased near-field intensities are
possible. These features are leveraged to obtain
104-105 fold signal enhancements and the direct
measurement of vibrational spectra of proteins at zepto-mole sensitivity
levels.
MANEJO E VIABILIDADE ECONÔMICA DA IRRIGAÇÃO NO CULTIVO DE Calendula officinalis L.
Authors: Aleman Catariny Cabral , Marques Patricia Angélica Alves
Published: April 2019

MANEJO E VIABILIDADE ECONÔMICA DA IRRIGAÇÃO NO CULTIVO DE Calendula officinalis L.  CATARINY CABRAL ALEMAN¹ E PATRICIA ANGÉLICA ALVES MARQUES² ¹Departamento de Engenharia Agrícola, UFV, Avenida PH Rolfs, s/n, 36570-000, Viçosa, MG, Brasil, e-mail: catariny@ufv.br²Departamento de Engenharia de Biossistemas, UFV, Avenida Pádua Dias, 11, 13418-900, Piracicaba, São Paulo, Brasil, e-mail: paamarques@usp.br  1 RESUMO O objetivo do trabalho foi verificar a influência de lâminas de irrigação baseadas na evaporação do Tanque Classe A (ECA) na produtividade e avaliar a viabilidade econômica do uso da irrigação e adubação orgânica no cultivo de calêndula. O experimento foi conduzido em um delineamento de blocos ao acaso, com esquema de parcelas subdivididas e quatro repetições. Os tratamentos de irrigação foram: sem irrigação (0), 50%, 75% e 100% ECA e o efeito da adubação orgânica: testemunha sem adubação orgânica e adubação orgânica com esterco bovino curtido. Avaliou-se massa seca de capítulos florais, produtividade, teor e rendimento de flavonóides, custos fixos e totais de produção, receitas líquida e relação B/C. A irrigação foi viável para o cultivo sem adubação para 75 e 100% ECA e para o cultivo com adubação apenas para 50% ECA. O manejo econômico adequado é a utilização de lâmina de irrigação de 100% ECA sem adição da adubação orgânica, utilizando motor elétrico com tarifa verde. Palavras-chave: análise de risco; manejo de recursos hídricos; eficiência do uso da água; plantas medicinais.  ALEMAN, C. C.; MARQUES, P. A.MANAGEMENT AND ECONOMIC VIABILITY OF IRRIGATION IN THE CULTIVATION OF Calendula officinalis L.   2 ABSTRACT The aim of the study was to determine the influence of irrigation levels based on pan evaporation Class A (ECA) in productivity and evaluate the economic feasibility of the use of irrigation and organic fertilizer on marigold cultivation. The experiment was conducted in a design of randomized blocks with split plots and a four-replication scheme. The irrigation treatments were: no irrigation (0) 50%, 75% and 100% ECA and the effect of organic fertilization: control with no fertilization and organic fertilization with cattle manure. We evaluated dry mass of capitula, productivity, content and yield of flavonoids, fixed and total costs of production, net income and B/C ratio. Irrigation was feasible for cultivation with no fertilization for 75 and 100% ECA and for cultivation with fertilizer, only at 50% ECA. Proper economic management is the use of irrigation depth of 100% ECA with no addition of organic fertilizers, using electric motor with green tariff. Keywords: risk analysis; management of hydric recourse; water use efficiency, medicinal plant.
A Phase II Trial of Selinexor (KPT-330) for Metastatic Triple-Negative Breast Cancer
Authors: Shafique Michael , Ismail-Khan Roohi , Extermann Martine , Sullivan Dan , Goodridge Dawn , Boulware David , Hogue Deanna , Soliman Hatem , Khong Hung , Han Hyo S.
Published: April 2019

Lessons Learned

Single-agent selinexor has limited activity in heavily pretreated patients with metastatic triple-negative breast cancer. Selinexor 60 mg by mouth twice weekly was generally well tolerated with a side-effect profile consistent with previous clinical trials. Future studies of selinexor in this population should focus on combination approaches and a biomarker-driven strategy to identify patients most likely to benefit.

Background

This phase II trial evaluated the safety, pharmacodynamics, and efficacy of selinexor (KPT-330), an oral selective inhibitor of nuclear export (SINE) in patients with advanced triple-negative breast cancer (TNBC).

Methods

This phase II trial was designed to enroll 30 patients with metastatic TNBC. Selinexor was given at 60 mg orally twice weekly on days 1 and 3 of each week, three of each 4-week cycle. The primary objective of this study was to determine the clinical benefit rate (CBR), defined as complete response + partial response + stable disease (SD) ≥12 weeks.

Results

Ten patients with a median age of 60 years (range 44–71 years) were enrolled between July 2015 and January 2016. The median number of prior chemotherapy lines was 2 (range 1–5). A planned interim analysis for the first stage per protocol was performed. Three patients had SD and seven had progressive disease. On the basis of these results and predefined stoppage rules, the study was halted.

Conclusion

Selinexor was fairly well tolerated in patients with advanced TNBC but did not result in objective responses. However, clinical benefit rate was 30%, and further investigation of selinexor in this patient population should focus on combination therapies.
EGZERSİZ YAPAN BİREYLERİN BOŞ ZAMAN ETKİNLİKLERİNE KATILIM MOTİVASYONLARINI ETKİLEYEN FAKTÖRLERİN İNCELENMESİ
Authors: ERDOĞAN Çağrı Hamdi , BAHADIR Ziya
Published: April 2019

Bu araştırmanın amacı Kayseri’deki spor
merkezlerinde düzenli olarak egzersiz yapan kişilerin boş zaman etkinliklerine
katılım motivasyonlarını etkileyen faktörlerin incelenmesi ve bu faktörlerin
bazı özelliklere göre karşılaştırılmasıdır. Tarama modelinde gerçekleştirilen
araştırmaya Kayseri’deki spor merkezlerinde Eylül-2017 ve Mart-2018 tarihleri
arasında düzenli olarak egzersiz yapan 377 kişi katılmıştır. Araştırmada veri
toplama aracı olarak Pelletier ve ark, (1991) tarafından geliştirilen ve Mutlu
(2008) tarafından Türkçeye uyarlanan “Boş Zaman Motivasyon Ölçeği” kullanılmıştır.
Araştırma verilerinin analizinde SPSS 22 programı kullanılmıştır. Araştırmanın
sonuçlarına göre boş zaman etkinliklerine katılım motivasyonlarını etkileyen
faktörlerin tamamının eğitim düzeyi, boş zamanlarda en sık yapılan faaliyet,
meslek ve gelir düzeyi bakımından anlamlı fark göstermediği; bazı faktörlerde
ise yaş ve medeni durum bakımından anlamlı fark ortaya çıktığı tespit
edilmiştir. Ayrıca genel olarak bireyleri boş zaman aktivitelerine motive
etmede “özdeşim-içeatım” faktörünün öne çıktığı belirlenmiştir.
Televizyonda-tribünde sporcuları izlemenin ve sosyal medyada ünlü sporcuları
takip etmenin egzersiz yapan bireylerde “özdeşim-içeatım” duygularına sebep
olabileceği tahmin edilmektedir. Başarılı sporcuların görsellerinin spor
merkezlerine daha dikkat çekici bir şekilde asılması ve ünlü sporcuların
etkileyici sözlerinin spor merkezlerinde afişe edilmesi, egzersiz yapan
bireylerin “özdeşim-içeatım” duygularını daha da geliştirmek için
önerilmektedir.
KAFEİN TAKVİYESİNİN KISA SÜRELİ YÜKSEK YOĞUNLUKLU EGZERSİZE ETKİSİ: KAFEİN ALIM ZAMANI
Authors: KARA Zülkif , TAŞKIN Halil , ERKMEN Nurtekin , BAŞTÜRK Dede
Published: April 2019

Araştırmada, yüklenmeden 60 dk ve 120 dk önce gerçekleştirilen kafein
takviyesinin kısa süreli yüksek yoğunluklu performansa etkisinin tespit
edilmesi amaçlanmıştır. On iki amatör erkek futbol oyuncusu (yaş: 22,69 ± 2,16 yıl, boy uzunluğu: 174,0 ± 7,12 cm, vücut ağırlığı: 70,55 ± 8,76 kg, spor deneyimi: 5,92 ±
2,96 yıl) araştırmaya katılmak
için gönüllü olmuştur. Katılımcılar 2 farklı zamanda kafein takviyesi ve
plasebo (PL) koşulu olmak üzere rastgele olarak 3 deney koşulunda araştırmaya
dahil edildiler. Kafein takviyesi, ölçümlerden 60 dk önce (KAF60) ve 120 dk
önce (KAF120) olacak şekilde gerçekleştirilmiştir. Her bir deney koşulu
arasında en az 3 gün ara verilmiştir. PL koşulunda katılımcılara sadece su
verilmiştir. KAF60 ve KAF120 koşulları için katılıcılara 250 ml suya
karıştırılmış olarak 6 mg/kg toz formundaki kafein takviyesi yapıldı. Her bir
deney koşulu için 5 m, 10 m, 20 m ve 30 m sürat, çeviklik, dikey ve yatay
sıçrama testleri uygulanmıştır.
Futbolcuların PL, KAF60 ve KAF120 koşullarında sürat performansları, çeviklik,
dikey sıçrama ve eller belde durarak uzun atlama mesafelerinin istatistiksel
olarak anlamlı farklılık göstermediği tespit edilmiştir (p > 0,05). KAF60 ve
KAF120 gruplarının PL grubundan, KAF120 grubunun ise KAF60 grubundan daha yüksek
eller serbest durarak uzun atlama mesafesine sahip oldukları belirlenmiştir (p
< 0,05). Sonuç olarak; kafein takviyesinin amatör futbol oyuncularının kısa
süreli yüksek şiddetli aktivitelerdeki performansını değiştirmediği, kafeinin
yüklenmeden 60 dk veya 120 dk önce yapılmasının herhangi bir etkiye sahip
olmadığı söylenebilir.
Gender-Specific differences in pulsed magnetic field exposed to diabetic neuropathic rats
Authors: Öcal Iþýl , Yýlmaz M. Bertan , Pelit Aykut , Çoban Fatma , Taºtekin Bora , Tabakan Ýbrahim
Published: April 2019

Type-1 diabetes mellitus is an insulin-dependent autoimmune disease, which is very common in the human populations regardless of gender. The aim of this study was to evaluate the effects of pulsed magnetic field (PMF), a non-invasive
procedure, on male and female rats with type 1 diabetes, particularly on weight loss ratios, blood glucose levels and diabetic neuropathy. Before, the experimental groups were divided into three groups as control (C (F or M), diabetes (DM (F or M),
controlled diabetes (DM(F)-INS or DM(M)-INS) groups according to their sex differences, then these experimental groups were exposed to magnetic field effect (PMF). The rats in the PMF groups were exposed to the pulsed magnetic field at 50 Hz (1.5 mT
intensity) for 1h/5days/month. The body weights and blood glucose levels were measured once a week over a month. Female and male diabetic rats developing diabetic neuropathy were evaluated with thermal (thermal latency) and dynamic (mechanical
threshold) plantar tests. After six-weeks of PMF treatment, the weight loss rate and increased blood glucose levels due to diabetes reversed in both female and male diabetic rats upon PMF treatment (p less than 0.05). In diabetic neuropathic female
and male rats, the thermal latency values increased, while the mechanical threshold values decreased. The reduction in diabetic neuropathic rats were statistically significant in diabetic rats (p less than 0.05). The increased or decreased mechanical
threshold and thermal latency values in diabetic neuropathic rats were statistically significant in only male diabetic rats (p less than 0.05). Our studies may imply that the effect of PMF in neuropathic pain is gender dependent further inferring
that hormonal mechanisms were also important in PMF dependent regulation.
Comparative evaluation of the in-vitro viability of canine and human blood preserved in citrate phosphate dextrose adenine (CPDA)-1 anticoagulated blood bag
Authors: Udegbunam R. I. , Njaka C. S. , Okereke H. N. , Udegbunam S. O.
Published: April 2019

Two hundred and fifty millilitres of blood each were drawn from healthy dogs (n=3) and volunteer human donors (n=3) into citrate phosphate dextrose adenine -1 anti-coagulated blood bags and preserved for 21 days. On days 0, 3, 7, 14 and 21,
selected hematological and biochemical parameters were evaluated. Red blood cells counts of canine and human blood showed no significant (p>0.05) difference till days 14 and 21 respectively. Mean corpuscular value (MCV) of canine blood on day 21
was significantly (p less than 0.05) higher than that of human blood. Erythrocyte catalase (CAT) and glutathione (GSH) progressively decreased while plasma potassium ion concentration of canine and human blood progressively increased. On day 21,
percentage decrease in canine RBC antioxidants was significantly higher when compared with that of human blood. The progressive decrease in RBC’s CAT and GSH suggests increased oxidative stress while progressive increase in K+ concentration and MCV
suggests RBC membrane damage.
Alien Species vs. Native Species: From Community Ecology to Eco-Evolutionary Dynamics
Authors: Prestes Andersonn Silveira
Published: April 2019

The establishment and spread of exotic species is a contemporary major concern. Alien species may become invasive in their new habitat, leading to both/either environmental and/or economic impacts. I briefly reviewed the literature in the last decade about the relationship of exotic species and native communities. I identified that professionals usually approach the subject in two main points of view: (1) researchers tend to point out the impacts of alien species on entire communities, evaluating if the relationship is positive, negative or neutral; (2) they focus on the eco-evolutionary processes involved in the introductions, the dynamics of invasion, and individual study cases. When evaluating the response of introductions to entire communities, evidence seems to be ambiguous and may support positive, negative or neutral relationship, especially depending on the scale approached. The unique eco-evolutionary pathways of each introduction may be a great shortcoming in the searching for generalities. On the other hand, advances have been made in understanding the dynamics of invasion on different lineages through a more selective/individualized approach. I suggest that the dynamics of invasion might be studied through a perspective in which different eco-evolutionary processes, levels of organization (from gene to entire communities), the history of the organism(s) and time are taken into account. Individual cases might be compared in attempt to understand how the relationship exotic and native works and in the search for generalities.
KAJIAN SUMBER ENERGI PADA PENGOLAHAN KELAPA SAWIT MENJADI CRUDE PALM OIL (CPO) DI PT. ALNO AGRO UTAMA SUMINDO OIL MILL, BENGKULU UTARA
Authors: Hidayat Lukman , Surawan Fitri Electrika Dewi , Raja Arga Harianda Lumban
Published: April 2019

Increasing demand for Crude Palm Oil (CPO) as the vegetable oil was causing the industry to cultivate palm oil increased, so that the energy required to produce CPO also increased. The purpose of this study is to identify the type, source and calculate the amount of energy needs, calculate the level of efficiency and energy savings opportunities. Stages of the research are  initial energy analysis, a detailed energy, and energy analysis in processing systems. Based on the research results, to produce each kg of CPO processing capacity of 60 ton TBS / hour with a recovery rate of 20.59% of primary energy needs of 16.200679 MJ / kg. Real boiler efficiency of 45.69%, the real efficiency of the turbine was 94, 86%. Turbine efficiency  to generate electrical energy by 1.09%, the technical efficiency of 66.80% turbines, diesel generators technical efficiency of 47.25%, the technical efficiency of electric motors by 59.37%.  The total efficiency  of  electricity  use by 4,75%, the efficiency of diesel estate of 1.379% and the efficiency of the use of steam at 93.77%. Energy can be saved by 0.0442 MJ / kg with a description of human powered energy of 0.0004316 MJ / kg, energy electrical energy by .04372 MJ / kg. While energy can be stored on the excess energy to fuel biomass boiler was 1.45 MJ / kg
Species distribution of yeasts recovered from different clinical samples Addiss Ababa,Ethiopia
Authors: Deribe Elias Seyoum , Bitew Adane , Mihret Amete
Published: April 2019

Background
Currently, fungal diseases of humans are among the most problematic illnesses is the result of an increase in opportunistic fungal infections caused by rise in the number of immune-compromised patients. Particularly, yeasts are the most common cause of fungal infections leading to a range superficial type to life-threatening invasive infections. The aim of this study is to determine species distribution of yeasts particularly of Candida species recovered from different clinical samples.

Method
A cross sectional study was conducted from January 01, 2018 –September 30, 2018 in Addis Ababa, Arsho laboratory. Oropharengial swabs, nail scrapings, sputum, corneal scrapings, and vaginal swabs were collected from patients with signs and symptoms of infections. Identification and antifungal susceptibility testing was performed by using YST card through VITEK 2 compact system. Data was entered and analyzed using SPSS version 20.

Result
A total of 209 yeasts were recovered of which 49.8% were Candida albicans, 43.1% were non-albicans candida species and 7.2% were yeasts other than Candida species. The current study, eighteen (18) different types of yeast species were identified from different clinical samples. All recognized yeast considered as a causative agent of fungal infection in previously reported data in worldwide.

Conclusion
C. albicans remaining the predominant species, but the emergence of non-albicans Candida and other than candida species have increased. Thus, more studies on Candida prevalence are needed throughout country.
Predictors to HIV testing among youth women in Ethiopia: 2016 Ethiopian Demographic and Health Survey
Authors: Diress Gedefaw , Ahmed Mohammed , Adane Seteamlak , Linger Melese , Aleminew Birhan
Published: April 2019

Background

HIV testing is the critical first step in identifying and linking HIV infected people to the treatment cascade and it also provides an important opportunity to reinforce HIV prevention among the negatives. The aim of this study was examine factors associated with HIV testing among youth women.

Methods

A community-based cross-sectional study design was used and a nationally representative secondary data analysis was done on the 2016 Ethiopian Demographic and Health Survey(EDHS). A total of 6401 youth women were eligible in the study. The data were analyzed by SPSS version 20. Frequencies and weighted percentage of the variables were calculated. Chi-square tests and logistic regression models were used to assess predictors of HIV testing. Multivariate logistic regression analysis was conducted to control confounders and to identify the independent contribution of each variable to the outcome variable.

Result

A total of 6401 youth women aged 15 to 24 years of age were included. Only 37.7% (95% CI:(33.6-39.1%)) of participants were ever tested for HIV in their life. In the final multivariable model age, marital status, level of educational, media access, number of sexual partner, STIs in Past 12 months and comprehensive knowledge to HIV, were significantly associated with ever been tested for HIV. Youth women who were in the age group between 20 to 24 (AOR=2.18; 95CI:(1.800-2.652), who were married (AOR=4.70; 95% CI:(3.674-6.008)), were divorced (AOR=6.16; 95% CI (3.976-9.541)), who had no access to media (AOR = 0.69; 95 CI %: (0.540-0.870)), who had no comprehensive HIV knowledge (AOR = 0.68; 65% CI: (0.530-0.861)) and having one or more sexual partners (AOR=2.48; 95% CI:(1.350-4.551)) were significantly associated with ever been tested for HIV.
The Progressive Journey of Phytosomes in Herbal Based Pharmacotherapeutics
Authors: Mahapatra Debarshi K. , Patil Shailendra , Patil Asmita G.
Published: April 2019

Background:

The primary objective of any pharmacotherapeutics approach entirely lies with
the effectiveness of the rationally designed delivery system to effectually deliver the suitable drug at the
appropriate concentration at the proper site. Phytosomes are most effective carrier for the possible enhancement
of bioavailability, reduction in the clearance rate, providing higher dissolution, and amplification
of solubility by several folds of various natural products.

Methods:

The present review article focuses exclusively on the recent global advancements in the
emerging novel drug delivery field of phytosomes from the year 1996 to present.

Results:

The article comprehensively highlights the reported phospholipid complexes of the active phytoconstituents
(18β-Glycyrrhetinic acid, Andrographolide, Baicalein, Baicalin, Berberine, Catechin,
Celastrol, Curcumin, Epigallocatechin-3-O-gallate, Evodiamine, Gingerol, Gymnemic acid, Icaritin,
Kaempferol, L-carnosine, Luteolin, Mitomycin-C, Piperine, Quercetin, Resveratrol, Rutin, Salicin,
Silibinin or Silybin or Silymarin, Sinigrin, and Umbelliferone) and herbal extracts (Aegle marmelos,
Allium cepa, Allium sativum, Bacopa monnieri, Boswellia serrata, Butea monosperma, Calendula officinalis,
Centella asiatica, Citrullus colocynthis, Ginkgo biloba, Glycine max, Lawsonia inermis, Mentha
pulegium, Momordica balsamina, Momordica dioica, Phyllanthus amarus, Phyllanthus emblica, Tecomella
undulate, and Woodfordia fruticosa) in treatment of various ailments along with the possible
enhancement of pharmacodynamics and pharmacokinetic attributes. The review also exhaustively focuses
on the clinical trials of several vesicular products and patents information.

Conclusion:

This article will be vital for the researchers of numerous fields who are working towards
the development of novel drug delivery system for translating better therapeutic effects of herbal based
components.
Combination of Aerobics and Resistance Training to Obesity University
Student Serum Visfatin Level Influence
Authors: Li Xuhui , Fan Xiaomei
Published: April 2019

Purpose: Discuss on combination of long-term aerobics and
resistance training to obesity university student serum visfatin level and blood
lipid metabolism influence, and reveal potential mechanism of losing weight
through exercises. Method: Divide 30 obesity university students
into 3 groups, control group (group C), aerobics group (group A as well as
aerobics and resistance training combinative group (group A+R), take in 16
periods’ training, before and after intervention respectively test the three
groups’ weight (W), body mass index (BMI),fat mass (FM), fat percentage (%F);
serum TG,TCH,HDL-C,LDL-C content and visfatin level, result:16 after 16 weeks
sports intervention, compare group A and group A+R with group C, W,BMI,FM,%F
obvious drop (P<0.05); serum TG,TCH,LDL-C content obvious drop (P<0.05), serum
HDL-C obvious rises (P<0.05), serum visfatin content obvious drops (P<0.05),
compare group A+R with group A, the FM,%F and serum visfatin content obvious
drop, other indicators have no significant differences. Relevant analysis finds
that serum visfatin content is positive correlated to W, BMI, FM, F%, TG, TCH
and LDL-C(P<0.05), and is negative correlated to HDL-C. Conclusion:
Both 16 weeks’ aerobics as well as combination of aerobics and resistance
training have good improvements to obesity university students’ weight and body
composition, and have good adjustment on blood lipid metabolic disorder, and
reduce serum visfatin level. Combination of aerobics and resistance training has
more obvious impacts on FM, % F and serum visfatin content, and meanwhile, serum
visfatin level is positive correlated to weight, BMI, %F, FM, TG, TCH, LDL-C,
while is negative correlated to HDL-C.