bluuebunny/crossref_metadata_2025 huggingface dataset:
Dual-Layer Spectral CT as Innovative Imaging Guidance in Lung Biopsies: Could Color-Coded Z-Effective Images Allow More Diagnostic Samplings and Biomarkers Information?
Authors: Piacentino Filippo , Fontana Federico , Zorzetto Giada , Saccomanno Angiola , Gatta Tonia , Recaldini Chiara , Franzi Francesca , Imperatori Andrea , Rotolo Nicola , Coppola Andrea , Minenna Manuela , Minici Roberto , Ascenti Velio , Tripodi Gianluca , Bottari Antonio , Laganà Domenico , Ierardi Anna Maria , Carrafiello Gianpaolo , Sessa Fausto , Carcano Giulio , Ascenti Giorgio , Venturini Massimo
Published: November 2023

The aim of the study was to try to obtain more information on diagnostic samplings and biomarkers using dual-layer spectral CT in lung biopsies. Lung biopsies were performed by merging images obtained with CBCT with those from spectral CT to use them as functional guidance, experimenting with double sampling to determine the difference between the area with a higher Z-effective number and that with a lower Z-effective number. Ten patients with large lung lesions on spectral CT were selected and underwent percutaneous transthoracic lung mass biopsy. Technical success was calculated. The percentage of neoplastic, inflammatory, fibrotic, necrotic cells, or non-neoplastic lung parenchyma was reported. The possibility of carrying out immunohistochemical or molecular biology investigations was analyzed. All lesions were results malignant in 10/10 samples in the Zmax areas; in the Zmin areas, malignant cells were found in 7/10 samples. Technical success was achieved in 100% of cases for Zmax sampling and in 70% for Zmin sampling (p-value: 0.2105). The biomolecular profile was detected in 9/10 (90%) cases in Zmax areas, while in 4/10 (40%) cases in Zmin areas (p-value: 0.0573). The advantage of Z-effective imaging would be to identify a region of the lesion that is highly vascularized and probably richer in neoplastic cells, thus decreasing the risk of obtaining a non-diagnostic biopsy sample.
Endocan as a Potential Marker for Predicting All-Cause Mortality in Hemodialysis Patients
Authors: Lin Jia-Hong , Hsu Bang-Gee , Wang Chih-Hsien , Tsai Jen-Pi
Published: November 2023

Endocan, a pro-inflammatory cytokine and pro-angiogenic factor, is a marker of endothelial dysfunction and has been proven to correlate with cardiovascular disease. In hemodialysis (HD) patients, cardiovascular disease is the major cause of mortality. Our study aimed to investigate the relationship between serum endocan and all causes of mortality in HD patients. A total of 103 patients, aged over 20 years old and undergoing HD for more than 3 months, were included and followed for 36 months. Mortality events, serum endocan, biochemical data, body mass index, systolic and diastolic blood pressure, baseline characteristics, and the use of antihypertensive and lipid-lowering drugs were recorded. In our study, a total of 26 deaths (25.2%) occurred. Hemodialysis patients with diabetes mellitus, older age, higher serum endocan, and lower creatinine and albumin levels had a higher risk of mortality. Adjusting for prognostic variables, HD patients with higher serum endocan (p = 0.010) and lower serum creatinine (p = 0.034) demonstrated significantly higher all-cause mortality. In our study, increased endocan and lower creatinine are associated with all-cause mortality in HD patients. Serum endocan levels could serve as a biomarker for a high mortality risk in HD patients.
Free Thyroxine (fT4) as a Potential Biomarker of Neurological and Functional Outcome in Acquired Brain Injury: A Prospective Multicenter Cohort Study
Authors: Mele Chiara , Bagnato Sergio , De Tanti Antonio , Lucca Lucia Francesca , Saviola Donatella , Marcuccio Laura , Moretta Pasquale , Scarponi Federico , Losavio Ernesto , Picciola Emilia , Pingue Valeria
Published: November 2023

The potential involvement of thyroid hormones (THs) in the neurological and functional recovery of patients with brain damage has been hypothesized. We aimed at investigating the role of THs and their variations during the rehabilitation process as predictive biomarkers of neurological and functional outcome in patients with acquired brain injury (ABI). This prospective, multicenter cohort study included 220 patients with ABI consecutively admitted for a 6-month neurorehabilitation program. Data on the etiology of the brain injury, occurrence of seizures, neurosurgical procedures, and death during hospitalization were collected. Both at the baseline (T0) and at the end of the rehabilitation process (T1), the following variables were evaluated: thyroid function (TSH, fT4, and fT3) and outcome measure including the Glasgow Coma Scale (GCS), Glasgow Outcome Scale-Extended (GOS-E), and Functional Independence Measure (FIM) scale. During neurorehabilitation, a significant decrease in fT4 levels was documented in the population as a whole and in patients with severe ABI (p < 0.0001), whereas no significant variations were found in TSH and fT3 levels. No significant associations were found between THs and seizure occurrence, while the neurological and functional outcomes were associated with the variation in fT4 levels during rehabilitation. In particular, a higher magnitude of decrease in fT4 levels emerged as an independent predictor of more severe neurological damage (OR = 3.48, CI 95% 1.04–11.69, p = 0.04) and a lower functional recovery (β = −0.22, p = 0.01). In conclusion, serum fT4 variation during neurorehabilitation could represent a potential biomarker of neurological and functional outcome in patients with ABI. Further studies are needed to investigate the mechanisms underlying this association.
Effects of the Saliva of Patients Undergoing Orthodontic Treatment with Invisalign and Brackets on Human Gingival Fibroblasts and Oral Epithelial Cells
Authors: Nemec Michael , Behm Christian , Sedlak Marcus , Nemec-Neuner Hemma , Nguyen Phuong Quynh , Jonke Erwin , Andrukhov Oleh
Published: November 2023

The transient worsening of oral health sometimes accompanies orthodontic treatment (OT), and the extent of this effect might depend on whether the patients are treated with traditional brackets or clear aligners. Saliva is an important tool for monitoring oral health and influences the functional properties of various oral cells. This study aimed to compare the effects of saliva from patients undergoing OT with Invisalign aligners and brackets on human gingival fibroblasts and oral epithelial cells in vitro. Unstimulated saliva was collected from 15 patients treated with Invisalign and 16 patients treated with brackets before and 3 and 6 months after therapy began. The saliva was used to stimulate primary human gingival fibroblasts and the oral epithelial Ca9-22 cell line, and the resulting cell response was investigated. Saliva did not exhibit any toxic effect on investigated cells, as shown by the proliferation/viability assay with the MTT method. In human gingival fibroblasts, saliva increased gene expression of various proinflammatory mediators, such as interleukin (IL)-6, IL-8, and monocyte chemoattractant protein-1, assessed by qPCR. In epithelial cells, saliva increased the production of IL-8 measured by ELISA and decreased gene expression of various proteins involved in the barrier function. During the therapy, the saliva-induced production of IL-8 tended to be decreased, and the saliva-induced decrease in the expression of barrier protein was partially improved. No difference between aligners and brackets was observed in either cell type. Saliva affects the functional properties of oral cells, but this effect is not influenced by the type of OT.
Hydrodynamic Simulation of Green Hydrogen Catamaran Operating in Lisbon, Portugal
Authors: Soni Gaurav , Neto Rui Costa , Moreira Lúcia
Published: November 2023

Similar to other industries, the maritime industry is also facing increasing restrictions on ships regarding pollution control. The research presented in this paper is aimed at studying the pros and cons of alternative fuels followed by a detailed analysis on hydrogen fuel cells (PEMFC) for a particular ship operating in Lisbon, Portugal. Dynamic forces acting on the ship have been studied for a year. Assessing various scenarios based on these results aids ship operators in making informed decisions regarding the future course of action for their existing vessels. These different cases are first: business as usual (diesel engine), second: replacing the diesel engine with a hydrogen hybrid system and, third: replacement of the ship with a new hydrogen hybrid ship. The study is based on the simulation of numerical equations and CFD simulation results. As the result, the second scenario is best suited in both aspects; namely, environmental and economic.
Study on the Lubricating Characteristics of Graphene Lubricants
Authors: Dong Yi , Ma Biao , Xiong Cenbo , Liu Yong , Zhao Qin
Published: November 2023

Graphene is considered a good lubricant additive. The lubricating properties of graphene lubricant at different concentrations and temperatures are studied via a four-ball friction and wear-testing machine. The results show that the coefficient of friction (COF) and wear scar diameter (WSD) of the steel ball with 0.035 wt% graphene lubricant decreased by 40.8% and 50.4%, respectively. Finally, through surface analysis, the following lubrication mechanism is proposed: as the added graphene particles can easily fill and cover the pores of the friction surface, the contact pressure of the rough peak is reduced, resulting in a lower COF and smoother surface. Although the COF increases with temperature, graphene lubricants still exhibit good lubrication effects.
Deciphering the Innovation Subsidy Puzzle: Government Choices amid Supply Chain Encroachment
Authors: Wang Jinglve , Yuan Hongping
Published: November 2023

Although the impact of government subsidies on private innovation has been widely recognized and researched in numerous studies, few have considered the increasingly prevalent phenomenon of supply chain encroachment in their analysis. This paper explores this phenomenon through a game-theoretic model that takes into account a government entity, a supplier, and a manufacturer. The primary aim is to understand how the government can make optimal subsidy decisions when the supplier moves into the supply chain. Several interesting conclusions have been drawn: (1) under governmental innovation subsidies, the supplier will raise the price of the new technology to obtain more potential revenue, which is termed the inverse wholesale price effect; (2) different kinds of innovation subsidies are shown to have varied effects on R&D, production, and consumption behavior; and (3) different subsidy strategies are made compatible with the characteristics of innovative activities to maximize social welfare as much as possible. These findings shed light on inconsistent results surrounding the impacts of government subsidies on private innovations in the existing literature, providing municipalities with helpful guidance when encouraging private innovation initiatives amid supply chain encroachment.
Influence of pH on the Inhibiting Characteristics of Cresol Red Incorporated in Chitosan Coatings on Zinc
Authors: Buier Regina , Szabó Gabriella Stefania , Katona Gabriel , Muntean Norbert , Muresan Liana Maria
Published: November 2023

The present work focuses on the investigation of protective coatings produced on zinc from chitosan (Chit) and an anionic dye, namely cresol red. Cresol red (CR) fulfills the basic requirements to be used as a corrosion inhibitor because it possesses a relatively high molecular weight and includes in its structure oxygen and sulfur atoms as well as aromatic rings. Moreover, it is an anionic compound that can interact with positively charged chitosan to produce reinforced coatings for zinc anti-corrosion protection. The influence of cresol red as a possible corrosion inhibitor for zinc substrates was investigated either in solution or incorporated in Chit coatings. Two preparation methods for the coatings were used: (i) Chit coating impregnation by immersion in the CR solution after Chit deposition on Zn, and (ii) chitosan mixing with the CR solution before applying the dip-coating technique. Potentiodynamic polarization curves were used to determine the kinetic parameters of the corrosion process. Long-term measurements were carried out in wet/dry cyclic conditions by using electrochemical impedance spectroscopy. EIS measurements recorded in 0.2 g/L Na2SO4 at pH = 7 show an important increase in the impedance of the coatings occurring from the first until the fifty-fifth day in a row, in dry–wet cycles. This increase is due to the beneficial effect of CR incorporated in Chitosan and could be, at least partially, related to a consolidation of the Chit coating structure in the presence of CR by crosslinking between Chit and CR molecules. The structure of the coatings was studied, and the interactions between chitosan and cresol red were put into evidence by using FT-IR spectroscopy. Adhesion and wettability measurements were also carried out. The adhesion of Chit incorporating CR on Zn was better than that on glass substrates and reached ~99.99%, suggesting a better affinity of the chitosan coating towards the Zn substrate due to the existence of ZnO on the substrate surface. All the results show that CR could be used on zinc as a corrosion inhibitor incorporated in chitosan at basic pHs, but without taking advantage of its pH-indicating properties, which are lost due to the interactions occurring between the positively charged biopolymer and the negatively charged dye molecule. The preparation method of Chit coating impregnation with CR by immersion in the solution after deposition on Zn led to poorer results than the method in which chitosan was previously mixed with CR before applying the dip-coating technique.
Effect of Ti/Al Ratio on Precipitation Behavior during Aging of Ni-Cr-Co-Based Superalloys
Authors: Chu Dong-Ju , Park Chanhee , Lee Joonho , Jung Woo-Sang
Published: November 2023

Precipitation behaviors of Ni-Cr-Co-based superalloys with different Ti/Al ratios aged at 750, 800, and 850 °C for up to 10,000 h were investigated using scanning and transmission electron microscopy. The Ti/Al ratio did not significantly affect the diameter of the γ′ phase. However, the volume fraction of the γ′ phase increased with increasing Ti/Al ratios. The η phase was not observed in alloys with a small Ti/Al ratio, whereas it was precipitated after aging at 850 °C for 1000 h in alloys with a Ti/Al ratio greater than 0.80. Higher aging temperatures and higher Ti/Al ratios led to faster η formation kinetics and accelerated the degradation of alloys. It is thought that the increase in hardness with an increase in the Ti/Al ratio is attributed to the effective inhibition of the γ′ phase on dislocation movement due to the increase in the volume fraction of the γ′ phase and an increase in the antiphase boundary (APB) energy.
The Effect of Pore Sealing in a Multilayer Si–O–Zr/Al2O3 Coating Designed to Protect Aluminium from Corrosion
Authors: Rodič Peter , Kapun Barbara , Milošev Ingrid
Published: November 2023

This study deals with the combination of two corrosion protection strategies for aluminium: barrier protection (provided by a 3.8 μm thick hybrid sol–gel coating) and aluminium pore sealing via the use of a 100 nm thick layer of aluminium oxide. A Si–O–Zr hybrid sol–gel coating (TMZ) was synthesised by combining two separately prepared sols (i) tetraethyl orthosilicate and 3-methacryloxypropyl trimethoxysilane and (ii) zirconium(IV) n-propoxide chelated with methacrylic acid. The synthesis of the Si–O–Zr hybrid sol–gel was evaluated at various stages using real-time infrared spectroscopy. A 100 nm thick Al2O3 film was prepared via thermal atomic layer deposition at 160 °C using trimethyl aluminium and water as precursors. The coating and film properties were assessed via focused ion beam/scanning electron microscopy coupled with energy-dispersive X-ray spectrometry. Sealing with the Al2O3 film did not affect the microstructure and composition of the underlying sol–gel coating. The coating’s corrosion performance in 0.1 M NaCl solution was evaluated using electrochemical impedance spectroscopy. Compared to individual coatings, the multilayer TMZ/Al2O3 coating ensured prolonged (more than three weeks) durable corrosion protection for the aluminium. The impedance magnitude increased by two orders compared to the uncoated substrate (|Z|10 mHz from 16 kΩ cm2 to almost 830 MΩ cm2). Thus, the pore sealing of the sol–gel coating using an ALD alumina film produced a protective multilayer coating system, with |Z|10 mHz remaining above 5 MΩ cm2 after four weeks in NaCl solution.
Editorial for the Special Issue on Flexible Sensors and Actuators for Biomedicine
Authors: Zhang Jingyan , Han Mengdi
Published: November 2023

Flexible sensors and actuators typically rely on functional materials with low Young’s moduli or ultrathin geometries [...]
Ideonella sakaiensis Can Metabolize Bisphenol A as a Carbon Source
Authors: Pop Cristian-Emilian , Deák György , Maria Cristina , Ghiță Gina , Ivanov Alexandru Anton , Fendrihan Sergiu , Mihăilescu Dan Florin , Mernea Maria
Published: November 2023

Bisphenol A and its analogues represent a significant environmental and public health hazard, particularly affecting the endocrine systems of children and newborns. Due to the growing need for non-pathogenic biodegradation microbial agents as environmentally friendly and cost-effective solutions to eliminate endocrine disruptors, this study aimed to investigate the degradation of bisphenol A by Ideonella sakaiensis, based on its currently understood unique enzymatic machinery that is already well known for degrading polyethylene terephthalate. The present study provides novel insights into the metabolic competence and growth particularities of I. sakaiensis. The growth of I. sakaiensis exposed to bisphenol A exceeded that in the control conditions, starting with 72 h in a 70% nutrient-rich medium and starting with 48 h in a 100% nutrient-rich medium. Computational modeling showed that bisphenol A, as well as its analogue bisphenol S, are possible substrates of PETase and MHETase. The use of bisphenol A as a carbon and energy source through a pure I. sakaiensis culture expands the known substrate spectra and the species’ potential as a new candidate for bisphenol A bioremediation processes.
Optimizing the Droplet-Vitrification Procedure by Balancing the Cryoprotection and Cytotoxicity of Alternative Plant Vitrification Solutions Based on the Nature of Donor Plant Vigor
Authors: Kim Haenghoon
Published: November 2023

Over 30 years of plant vitrification, droplet vitrification (DV) of in vitro propagules and slow freezing of dormant buds are typical methods of large-scale cryobanking worldwide. One-step sucrose preculture and Plant Vitrification Solution 2 (PVS2) cryoprotection in solution-based vitrification often face unacceptably low regeneration, and the results are on a case-by-case basis depending on the plant species, like a blind test. The absence of a universal protocol applicable across all plant diversity is considered one of the limiting factors. For wild flora, limits of source material available and difficulties in in vitro propagation make it worse to re-optimize the protocol steps for new species. Since cryoprotectant toxicity is the most crucial barrier to the vitrification of organized explants, selecting alternative plant vitrification solutions (PVS) based on the cytotoxicity of cryoprotectants is vital. This review proposes the concept of donor plant vigor (DPV), which refers to the donor plant properties that determine the potential to regenerate normal plantlets under various cryopreservation procedures. DV is a multi-stage procedure with many factors from stage (1) material preparation to (2) pre-liquid nitrogen (pre-LN) (preculture, osmoprotection, cryoprotection), (3) LN (cooling), (4) warming conditions (rewarming, unloading), and (5) regrowth. Since the cytotoxicity of PVS is a primary limiting factor in DV approaches, DPV is crucial for coping with the toxicity of PVS. The DPV is innate and can be maximized with appropriate material preparations, i.e., vigorously growing in subcultures aided by a liquid overlay on top of the gelled medium, selecting proper explants, optimizing the two-step preculture conditions, and media supplements. Developing the DV protocol starts with testing the material with a tentative standard protocol, which includes a two-step preculture (10% sucrose for 31 h and 17.5% sucrose for 16 h), osmoprotection with C4-35%, cryoprotection with A3-80% (60 min at 0 °C), cooling, and rewarming using aluminum foil strips. Using a three-step regrowth initially with ammonium-free regrowth medium, regrowth of shoot tips in one plate following the successive stages of the tentative standard protocol for shoot tips, i.e., fresh, PC, OP, CP (LNC), and LN, is a valuable tool to characterize the sensitivity of the material and to standardize the procedure by tuning the cryoprotection and cytotoxicity of cryoprotectants. A-series PVS (A3-90%, A3-80%, A3-70%) and B-series PVS (PVS3, B5-85%) can be tested based on the DPV. These alternative PVSs have been applied in over 30 pieces of literature with an 8.5~67.3% increase in LN regeneration compared to PVS2 and Plant Vitrification Solution 3 (PVS3) treatments. Using this approach as an alternative to blind condition screening would be influential in broadening the cryopreservation of diverse wild species and problem materials.
Comparison of Different Machine Learning Algorithms for the Prediction of the Wheat Grain Filling Stage Using RGB Images
Authors: Song Yunlin , Sun Zhuangzhuang , Zhang Ruinan , Min Haijiang , Li Qing , Cai Jian , Wang Xiao , Zhou Qin , Jiang Dong
Published: November 2023

Grain filling is essential for wheat yield formation, but is very susceptible to environmental stresses, such as high temperatures, especially in the context of global climate change. Grain RGB images include rich color, shape, and texture information, which can explicitly reveal the dynamics of grain filling. However, it is still challenging to further quantitatively predict the days after anthesis (DAA) from grain RGB images to monitor grain development. Results: The WheatGrain dataset revealed dynamic changes in color, shape, and texture traits during grain development. To predict the DAA from RGB images of wheat grains, we tested the performance of traditional machine learning, deep learning, and few-shot learning on this dataset. The results showed that Random Forest (RF) had the best accuracy of the traditional machine learning algorithms, but it was far less accurate than all deep learning algorithms. The precision and recall of the deep learning classification model using Vision Transformer (ViT) were the highest, 99.03% and 99.00%, respectively. In addition, few-shot learning could realize fine-grained image recognition for wheat grains, and it had a higher accuracy and recall rate in the case of 5-shot, which were 96.86% and 96.67%, respectively. Materials and Methods: In this work, we proposed a complete wheat grain dataset, WheatGrain, which covers thousands of wheat grain images from 6 DAA to 39 DAA, which can characterize the complete dynamics of grain development. At the same time, we built different algorithms to predict the DAA, including traditional machine learning, deep learning, and few-shot learning, in this dataset, and evaluated the performance of all models. Conclusions: To obtain wheat grain filling dynamics promptly, this study proposed an RGB dataset for the whole growth period of grain development. In addition, detailed comparisons were conducted between traditional machine learning, deep learning, and few-shot learning, which provided the possibility of recognizing the DAA of the grain timely. These results revealed that the ViT could improve the performance of deep learning in predicting the DAA, while few-shot learning could reduce the need for a number of datasets. This work provides a new approach to monitoring wheat grain filling dynamics, and it is beneficial for disaster prevention and improvement of wheat production.
Revolutionizing Energy Storage: Exploring Processing Approaches and Electrochemical Performance of Metal-Organic Frameworks (MOFs) and Their Hybrids
Authors: Khalid Wajahat , Karim Muhammad Ramzan Abdul , Marwat Mohsin Ali
Published: November 2023

The text highlights the growing need for eco-friendly energy storage and the potential of metal-organic frameworks (MOFs) to address this demand. Despite their promise, challenges in MOF-based energy storage include stability, reproducible synthesis, cost-effectiveness, and scalability. Recent progress in supercapacitor materials, particularly over the last decade, has aimed to overcome these challenges. The review focuses on the morphological characteristics and synthesis methods of MOFs used in supercapacitors to achieve improved electrochemical performance. Various types of MOFs, including monometallic, binary, and tri-metallic compositions, as well as derivatives like hybrid nanostructures, sulfides, phosphides, and carbon composites, are explored for their energy storage potential. The review emphasizes the quest for superior electrochemical performance and stability with MOF-based materials. By analyzing recent research, the review underscores the potential of MOF-based supercapacitors to meet the increasing demands for high power and energy density solutions in the field of energy storage.
Regulación de emociones a través del dibujo infantil
Authors: Ticona Mamani Martha , García Bedoya Nancy Mónica , Chusi Sacaca Cenaida , Apaza Arapa Miriam Antonieta
Published: November 2023

La situación vivida durante la pandemia, generó diversas situaciones emocionales de miedo y ansiedad, aumentó la sensación de pérdida de libertad, puesto que ya no se podía disfrutar de la compañía física de los otros. El estudio tuvo como propósito, identificar la influencia del dibujo infantil en la regulación de emociones, investigación de tipo experimental y diseño pre experimental con pre y pos prueba con un solo grupo. La población fue constituida por 97 niños, con la muestra de 20 niños, elegidos aleatoriamente, se utilizó la técnica de la encuesta y el instrumento fue el cuestionario, de la escala de ansiedad, con 20 preguntas, aplicado a padres de familia, quienes respondieron sobre las actitudes de sus hijos, se desarrollaron 15 talleres de dibujo. Para el análisis de resultados se utilizó el estadístico chi – cuadrada 16 (????????). Llegando a la conclusión, que el dibujo infantil como estrategia ayuda en la regulación de las emociones, tal como muestran los resultados de acuerdo al baremo de interpretación, pasando de un nivel medio a un nivel alto en la regulación emocional.
Desain Angkringan Sebuah Resiliensi Saat Pandemi Covid-19
Authors: Utami Ni Kadek Yuni , Trisna Ni Made Sri Wahyuni
Published: November 2023

Pemanfaatan ruang luar sebagai resiliensi di masa pandemi seolah menjawab kebutuhan masyarakat terhadap interaksi sosial saat diberlakukannya peraturan pembatasan sosial fisik dalam melakukan aktivitas. Angkringan sebagai tempat makan di ruang luar mulai banyak bermunculan saat situasi pandemi Covid-19 dengan menawarkan harga makanan terjangkau, desain tempat sederhana dan upaya penyesuaian lain yang mengikuti aturan protokol kesehatan. Hal ini membuat masyarakat tertarik untuk mengunjungi dan menghabiskan waktu di tempat tersebut. Penelitian ini dilakukan dengan tujuan untuk menganalisis desain angkringan sebagai resiliensi di masa pandemi. Selain itu penelitian ini juga dapat memberi wawasan terhadap desainer interior atau arsitek terhadap pemanfaatan ruang luar selama pandemi dan menjadi panduan saat endemi. Metode pengumpulan dilakukan dengan menyebar kuesioner kepada 100 responden pengunjung angkringan dan observasi ke angkringan Temu Rasa di area parkir Pusat Oleh-Oleh Cening Ayu, Sukawati, Gianyar. Observasi menekankan pada upaya yang dilakukan pihak pengelola untuk menciptakan ruang luar yang nyaman dan aman saat pandemi. Data observasi akan dikomparasi dengan hasil preferensi masyarakat terhadap angkringan saat pandemi. Dengan menggunakan teori yang relevan diharapkan melalui penelitian ini dapat diketahui upaya resiliensi desain yang meliputi layout, sirkulasi, material, furniture yang dilakukan pada desain angkringan untuk menjawab kebutuhan terhadap ruang luar yang aman, nyaman, dan sesuai dengan protokol kesehatan.
Inovasi Ecollabo8 pada Sampah Plastik untuk Kebutuhan Interior
Authors: Sahita Cita Luvi , Setyoningrum Yunita
Published: November 2023

Plastic waste is one of the biggest causes of environmental pollution, especially soil and sea pollution. Proper management is needed to reduce the impact of plastic waste on the environment. Meanwhile, in Indonesia, waste management has not been able to reduce the impact of plastic waste by recycling and turning it into something more valuable. Ecollabo8 impact of plastic waste itself. It is necessary to process plastic waste that can be reused and increase the value of recycled products. Ecollabo8 is a community that aims to recycle plastic into interior materials, such as furniture, wall coverings, or materials for interior aesthetic elements. The purpose of this research is to provide information and references related to the processing of plastic waste from various categories so that it can become an interior material innovation by Ecollabo8. The research method used is the netnographic method by observing the activities and culture of Ecollabo8 through social media and online documentation.
Criticism of the digital ruble project
Authors: Kozenko Yu. A.
Published: November 2023

During the search for a worthy candidate for the BRICS currency, such digital means of payment that are understandable and acceptable to all participants in financial relations begin to play a special role. For this reason, innovations in the field of the digital ruble should be objectively subjected to scrupulous analysis and constructive criticism, which can eliminate a significant part of doubts about the correctness of the practical implementation of this project. The historically determined period of the beginning of the transition to a new material carrier of value, which takes the form of a digital signal, should make maximum use of high-quality scientific support and in no way discredit the relevant scientific approaches.
Are Tech Companies Dangerously Veering Away from Their Managerial Accountabilities?
Authors: Malhotra Ash
Published: November 2023

A disturbing pattern is emerging on the corporate horizon. At first glance, the tech companies seem to have solutions to every problem. But is that right? What about the Covid-19 pandemic, looming global wars, terrorism and climate change, and other issues such as the growing impact of AI? Tech companies often seem to be operating outside the framework of ethics and managerial decision-making rules, with weak synchronisation between stakeholders, and regulatory systems are not being activated. Social accountabilities are being thrown to the wind, with global implications in our interconnected world. This essay discusses management, and whether tech companies need to be reined in, focusing on media sources reporting on problems of governance by technocrats.
Numerical Modelling Based on Large-Angle Oscillation Theory in Determining the Rotating Inertia of a Rotor Subjected to Frictions
Authors: Pagwiwoko Cosmas , Short Robert
Published: November 2023

This research discusses a numerical method used for determining the mass moment of inertia of a rotor that has been validated through laboratory tests. In this technique, the rotor is considered as a pendulum where an additional mass is mounted at the outskirt underneath the rotor. The equation of motion of this pendulum is then established, based on the oscillating unbalanced rotor, and the magnitude of the inertia is extracted from the free oscillating response. Nonlinear theory of pendulums with large-angle oscillation is applied to estimate the mass moment of inertia. While this mathematical theory considerably improves the result, the dry friction acting on the bearing of the rotor still creates a significant inaccuracy. This research proposes a resolution to alleviate this erroneous calculation by applying a remedy factor in interpreting the nonlinear response of the pendulum.
La utopía encubierta: estrategias de localización de la aventura de ciencia ficción en El Eternauta (1957-1959) de Héctor G. Oesterheld y Francisco Solano López
Authors: Quereilhac Soledad
Published: November 2023

El presente artículo indaga en las razones que llevaron a la historieta argentina El Eternauta, creada por Héctor German Oesterheld y Francisco Solano López, a convertirse en una obra de exitosa recepción durante su publicación original por entregas en Hora Cero Semanal, entre 1957 y 1959, y en las sucesivas reediciones posteriores, hasta convertirse hoy en un “clásico” de la ficción argentina. Se analiza el paso de Oesterheld por la revista Más Allá (1953-1957) y sus comienzos como cuentista, guionista de historietas y divulgador de temas científicos en sellos comerciales y, luego, en su propio sello, Frontera. El perfil profesional del autor fue la condición de emergencia de una forma particular de la historieta, donde se combinaron con eficacia convenciones de la industria cultural y un proyecto creativo individual.

Se sostiene la hipótesis de que, en El Eternauta, tras la escena distópica, aflora como subtexto la utopía de una vida argentina con perspectivas de progreso, marcada por la sociabilidad masculina y la armonía de una familia tipo, el manejo de saberes técnico-científicos que recorren el amplio espectro de lo académico, lo fabril y el amateurismo, y los lazos de solidaridad y de filantropía que movilizan las acciones de la resistencia. La distopía permite hacer emerger, así, en posición de riesgo y de amenaza, esa construcción idealizada y afirmativa de la vida en común, de identificables rasgos nacionales.
Dissection of FOXO1-Induced LYPLAL1-DT Impeding Triple-Negative Breast Cancer Progression via Mediating hnRNPK/β-Catenin Complex
Authors: Tang Yuhui , Tian Wenwen , Zheng Shaoquan , Zou Yutian , Xie Jindong , Zhang Junsheng , Li Xing , Sun Yuying , Lan Jing , Li Ning , Xie Xiaoming , Tang Hailin
Published: November 2023

Triple-negative breast cancer (TNBC) is considered as the most hazardous subtype of breast cancer owing to its accelerated progression, enormous metastatic potential, and refractoriness to standard treatments. Long noncoding RNAs (lncRNAs) are extremely intricate in tumorigenesis and cancerous metastasis. Nonetheless, their roles in the initiation and augmentation of TNBC remain elusive. Here, in silico analysis and validation experiments were utilized to analyze the expression pattern of clinically effective lncRNAs in TNBC, among which a protective lncRNA LYPLAL1-DT was essentially curbed in TNBC samples and indicated a favorable prognosis. Gain- and loss-of-function assays elucidated that LYPLAL1-DT considerably attenuated the proliferative and metastatic properties along with epithelial-mesenchymal transition of TNBC cells. Moreover, forkhead box O1 (FOXO1) was validated to modulate the transcription of LYPLAL1-DT. Mechanistically, LYPLAL1-DT impinged on the malignancy of TNBC mainly by restraining the aberrant reactivation of the Wnt/β-catenin signaling pathway, explicitly destabilizing and diminishing β-catenin protein by interacting with heterogeneous nuclear ribonucleoprotein K (hnRNPK) and constricting the formation of the hnRNPK/β-catenin complex. Conclusively, our present research revealed the anti-oncogenic effects of LYPLAL1-DT in TNBC, unraveling the molecular mechanisms of the FOXO1/LYPLAL1-DT/hnRNPK/β-catenin signaling axis, which shed innovative light on the potential curative medicine of TNBC.
Zwischen Selbstführung und direktiver Führung
Authors: Rybnikova Irma , Menzel Viktoria , Beierlein Constanze , Kempny Christian
Published: November 2023

In demokratischen Regierungssystemen sind ehrenamtliche Wahlhelfende bei der Durchführung von Wahlen unerlässlich. Die ehrenamtliche Tätigkeit findet dabei in festgelegten Strukturen und im Rahmen vorgegebener Prozesse statt. Um insbesondere Führungsprozesse und -strukturen in Wahlvorständen naher zu beleuchten, wurden im Jahr 2022 im Anschluss an die Landtagswahl in Nordrhein-Westfalen 23 Wahlhelfende in einer Interviewstudie befragt. Die Auswertung erfolgte computergestutzt mittels einer qualitativen Inhaltsanalyse. Die Ergebnisse zeigen, dass die Wahlhelfenden über eine hohe Arbeitsmotivation verfügen, die sich aus intrinsischen und extrinsischen Motiven (z. B. Verpflichtungsgefühl, soziale Zusammenkunft, Sonderurlaub) speist. Die Führungsprozesse in den Wahlvorständen werden über Vorgaben und Instanzen, über die Selbstführung im Team sowie über die Führung durch Wahlvorstehende umgesetzt. Eine solche Führungskonstellation kommt dem Konzept der verteilten Führung sehr nahe und verdeutlicht seine Relevanz für den ehrenamtlichen Kontext.
Entwurf eines Manifests für Gesunde Organisationen
Authors: Paust Robert , Schaff Arnd
Published: November 2023

Ein Manifest ist ein Appell zur Veränderung eines Status quo, der in den Augen der Verfasser:innen nicht mehr zukunftsfähig ist. Hier im Fokus: der Mangel an Ernsthaftigkeit und Nachhaltigkeit bei der Gestaltung und Weiterentwicklung von betrieblichem Gesundheitsmanagement (BGM) – trotz der großen Relevanz des Themas in Zeiten von zunehmender Dynamik und Komplexität im Allgemeinen, von Fachkräftemangel, Teilzeit- und Frühverrentungswellen oder einer ≫Mental Health Crisis≪ im Besonderen.
Pengaruh Fasilitas Kerja Dan Gaji Terhadap Kepuasan Kerja Karyawan Pada PT. Medan Distribusindo Raya (Mdr)Di Kota Medan
Authors: Dianto Dianto , Ikhwana Hablil , Pratidina Siti Wardah
Published: November 2023

Peneiltian ini bertujuan untuk mengetahui apakah fasilitas kerja dan gaji baik secara parsial maupun simultan berpengaruh signifikan terhadap kepuasan kerja di PT. Medan Distribusindo Raya (MDR) di kota Medan dan seberapa pengaruhnya. Metode yang digunakan dalam peneltian ini adalah Metode kuantitatif dengan beberapa uji yakni reliabiiity analysis, uji penyimpangan asumsi klasik dan regresion linier. Berdasarkan hasil regresi data primer yang diolah dengan menggunakan SPSS 20, diperoleh persamaan regresi linier berganda sebagai berikut: Y 9,575 +0,526 X?+0,649 X? Secara parsial, variabel fasilitas kerja (X1) memiiiki pengaruh yang positif dan signifikan terhadap kepuasan kerja (Y). Artinya hipotesis pada penelitian ini diterima, terbukti dari nilai t hitung > t tabel (3,043 > 2,052). Sedangkan variabel gaji (X2) memiiiki pengaruh signifikan terhadap kepuasan kerja karyawan (Y). Artinya hipotesis pada penelitian ini diterima, terbukti dari nilai t hitung > t tabel (4,279 > 2,052). Secara simultan variabei fasilitas kerja (X1) dan gaji (X2) memiiiki pengaruh yang positif dan signifikan terhadap kepuasan kerja (Y). Artinya hipotesis pada penelitian ini diterima terbukti dari niiai F hitung > F tabel (10.918 > 3,11). Variabei fasilitas kerja (X1) dan gaji (X2) mampu memberikan kontribusi pengaruh terhadap variabel kepuasan kerja sebesar 44,6% sedangkan sisanya sebesar 55,4% dipengaruhi oleh variable lain. Dari kesimpuian di atas penulis memberikan saran bahwa pimpinan seharusnya memberikan fasilitas kerja yang layak sesuai dengan peraturan yang berlaku agar karyawan dapat bekerja dengan senang hati. Karyawan harus tetap bekerja dengan semangat dan disiplin agar pimpinan dapat mempertimbangkan gaji yang diinginkan.
Strategi Pengembangan UMKM Danau Toba Pasca Pandemi Covid-19 sebagai Destinasi Pariwisata Super Prioritas
Authors: Adamy Zulham , Wiradharma Gunawan , Prasetyo Mario Aditya , Evriza Eka , Igiriza Miftahunnisa
Published: November 2023

Industri pariwisata paling terdampak oleh Covid-19 dan lambat pulihnya, begitu pun dengan para pelaku UMKM di daerah destinasi wisata tersebut. Melakukan penelitian dengan tujuan untuk memahami kondisi UMKM, mengidentifikasi faktor-faktor penentu pertumbuhannya, dan menawarkan saran untuk merancang strategi di destinasi pariwisata super prioritas di Indonesia pasca-Covid-19 sangatlah penting. Tujuan dari penelitian ini adalah untuk mengetahui strategi pengembangan yang akan meningkatkan efektivitas bisnis dan daya saing UMKM di Danau Toba, salah satu tujuan wisata prioritas utama di Indonesia. Metode penelitian kualitatif digunakan untuk mengumpulkan data untuk penelitian ini, termasuk survei lokasi, wawancara dengan karyawan layanan, UMKM, dan wisatawan. Analisis deskriptif digunakan untuk mengidentifikasi kondisi dan beragam tantangan yang dihadapi oleh UMKM di Danau Toba. Hal ini kemudian dilakukan analisis SWOT yang terdiri dari analisis faktor internal dan eksternal. Di tengah pandemi Covid-19, temuan penelitian ini menawarkan strategi pengembangan bisnis yang efektif bagi UMKM di kawasan Danau Toba untuk meningkatkan daya saingnya.
Pemanfaatan E-Commerce Pada Penjualan Produk Usaha Asinan Myesha Di Kota Kendari
Authors: Siama Romi Apriadi , Nuryadi Ahmad Muhlis , Rosmalah Sitti
Published: November 2023

This study aims to determine the use of e-commerce in product sales Myesha pickled business in kendari city. This research was conducted from June to July 2023. The data used in this study is primary data obtained by conducting interview directly with the owner of the Myesha Asinan business. Method of collecting data In this study using a survey method. The analytical method used in this research is a descriptive method with a quantitative approach, to describe sales Asinan Myesha business products in utilizing e-commerce. The results of the research show that the benefits of e-commerce in selling Asinan Myesha business products, that is, can help expand market reach, increase brand awareness, make it easy for customers to make purchases, save costs, manage shipments more easily, and can help increase the number of orders and sales turnover.

Keywords: utilization, e-commerce, sales, business, pickles
Determining The Selling Price of Thrift Using The Fuzzy Sugeno Method
Authors: Radhiah Radhiah , Rusdiana Siti , Hamdi Syaiful , Nurmaulidar Nurmaulidar , Syahrini Intan , Mahmudi Mahmudi , Ikhwan Muhammad
Published: November 2023

The use of thrift goods in life has the effect of saving and loving the environment. Many of these objects are difficult to degrade in nature and are nevertheless thought to have economic worth, for example used electronic equipment such as laptops. On the other hand, in today's classroom environment, laptops are quite important. Even the most recent computers with good features are fairly costly, thus used laptops are one answer to this. The seller's selling price usually only takes a few elements into account, therefore the price set does not always match the requirements. The aim of this paper is to apply the zero order Sugeno fuzzy approach to determine the selling price of old laptop. The system is built with characteristics such as laptop age, physical condition, RAM, new purchase price, and used selling price. The simulation findings suggest that fuzzy logic employing the zero-order Sugeno approach can be utilized to determine the selling price of old laptop while accounting for the affecting variables.
Siguiendo los rastros de una clase social aparentemente inexistente: La formación de la clase media durante la República Liberal (1930-1946) a partir de la Federación de Empleados de Bogotá
Authors:   , Bacca Contreras Rafael Eduardo
Published: November 2023

La presente tesis trata sobre una de las caras del nacimiento de la clase media colombiana, particularmente tomando como estudio de caso a la Federación de Empleados de Bogotá (FEB) durante la República Liberal (1930-1946). Desde este caso, ha sido posible tanto interrogar a algunas investigaciones que han negado la existencia de esta clase social para estos años, así como relacionar su surgimiento y sus distintas campañas pro clase media como consonantes, no sin contratiempos, al proyecto de modernización de estos gobiernos liberales. Para demostrar esto, metodológicamente en este proyecto se usó una metodología etnográfica respecto a diversos documentos históricos, entre ellos se pueden destacar cartas de empleados, informes y otros documentos ministeriales y presidenciales de esta época, así como una exhaustiva revisión del periódico El Tiempo entre 1930 y 1946, el periódico Nosotros a partir de los únicos documentos disponibles comprendidos entre 1934 y 1937, además de revisitar obras relevantes tanto para el periodo histórico como sobre los pocos estudios de clase media colombiana y latinoamericanos afines. Esta propuesta, entonces, permite no sólo afirmar la existencia y las especificidades materiales y simbólicas con las que los empleados -y empleadas con su gremio propio- se estructuraron en un intermedio social, sino también cómo este se construyó respecto a una idea progresista, es decir, una clase media atemperada políticamente, mesurada y prudente moralmente, así como empoderada como guía cultural -tanto para toda la clase media como para la clase obrera- para el país que se estaba reformando con un discurso modernizante. En este ámbito, nace -y hacen nacer actores intelectuales y políticos, con fuertes discusiones ideológicas como se verá- esta clase media nucleada principalmente en empleados y empleadas y que se centrará como eje de progreso y médula de la democracia.
EMPIRICAL RESEARCH ON THE RELATIONSHIP BETWEEN DUAL-SOURCE INNOVATION BEHAVIOR, ENTREPRENEURIAL BRICOLAGE, AND BUSINESS MODEL INNOVATION
Authors: Zhao Siwei
Published: November 2023

Innovation and entrepreneurship are regarded as one of the core issues in economic and social development. Supported by dualism theory, resource-based theory, and entrepreneurial process theory, this paper constructs a research framework that includes the following elements: dual-source innovation behavior, entrepreneurial bricolage, environmental uncertainty, and business model innovation. This research framework helps to dissect the influence of different factors on the entrepreneurial and innovation process, thus providing an in-depth understanding and analysis. A theoretical model is established based on the four variables, studying their interrelationships. Through distributing survey questionnaires, empirical analysis was conducted on the collected data samples. The research findings of this paper present several discoveries: 1) Dual-source innovation behavior positively affects the business model. 2) Entrepreneurial bricolage acts as a mediating variable, positively influencing the relationship between dual-source innovation behavior and business model innovation. 3) Environmental uncertainty exerts a positive moderating effect on the relationships among dual-source innovation behavior, business model innovation, and entrepreneurial bricolage. The research results suggest that entrepreneurs can enhance their business model innovation capabilities by relying on dual-source innovation behaviors, and how to undertake entrepreneurial bricolage in dynamic competition, offering practical considerations and recommendations for businesses.