bluuebunny/crossref_metadata_2025 huggingface dataset:
The inner kernel theorem for a certain Segal algebra
Authors: Feichtinger Hans G. , Jakobsen Mads S.
Published: May 2022

The Segal algebra$${\mathbf{S}}_{0}(G)$$S0(G)is well defined for arbitrary locally compact Abelian Hausdorff (LCA) groupsG. It is a Banach space that exhibits a kernel theorem similar to the well-known Schwartz kernel theorem. Specifically, we call this characterization of the continuous linear operators from$${\mathbf{S}}_{0}(G_1)$$S0(G1)to$${\mathbf{S}}'_{0}(G_2)$$S0′(G2)by generalized functions in$${\mathbf{S}}'_{0}(G_1 \times G_2)$$S0′(G1×G2)the “outer kernel theorem”. The main subject of this paper is to formulate what we call the “inner kernel theorem”. This is the characterization of those linear operators that have kernels in$${\mathbf{S}}_{0}(G_1 \times G_2)$$S0(G1×G2). Such operators are regularizing—in the sense that they map$${\mathbf{S}}'_{0}(G_1)$$S0′(G1)into$${\mathbf{S}}_{0}(G_2)$$S0(G2)in a$$w^{*}$$w∗to norm continuous manner. A detailed functional analytic treatment of these operators is given and applied to the case of general LCA groups. This is done without the use of Wilson bases, which have previously been employed for the case of elementary LCA groups. We apply our approach to describe natural laws of composition for operators that imitate those of linear mappings via matrix multiplications. Furthermore, we detail how these operators approximate general operators (in a weak form). As a concrete example, we derive the widespread statement of engineers and physicists that pure frequencies “integrate” to a Dirac delta distribution in a mathematically justifiable way.
Primary reconstruction of extensive orbital fractures using two-piece patient-specific implants: the Helsinki protocol
Authors: Salli Malla I. , Nikunen Matti , Snäll Johanna
Published: May 2022

Purpose

We present our experience of titanium-milled two-piece patient-specific implants (PSIs) for primary reconstructions of extensive orbital floor and medial wall fractures (EOFMFs) and evaluate their postoperative functional and aesthetic outcomes in relation to commercially available implants.

Methods

We included all patients with primary reconstructions (< 22 days from injury) of EOFMFs treated in our department between January 2011 and October 2020. Extensive orbital floor and medial wall fracture was defined as involvement of orbital floor, medial wall and maxilloethmoidal junction; a fracture defect 5 mm or more; defect size more than a third of both inferior and medial walls; and Jaquiéry classification III or more. Patient characteristics, details of fracture defects and surgeries, postoperative outcomes and implant positions were retrospectively evaluated and compared between study groups.

Results

Nineteen patients were included: 5 with two-piece PSIs and 14 with commercial implants. Implant position was good in 4/5 patients with two-piece PSIs and 2/14 with commercial implants. Revision surgery, globe malposition (GMP) > 2 mm, significant diplopia and poor implant position were more frequent in patients with commercial implants than two-piece PSIs. None of the patients with a good overall implant position had any significant postoperative symptoms.

Conclusion

Extensive orbital fracture reconstructions are somewhat rare, and surgical treatment is associated with a high rate of complications and postoperative symptoms. Titanium-milled two-piece PSIs are well suited for primary reconstructions of EOFMFs, as they lead to more precise reconstructions and fewer postoperative symptoms than commercially available implants.
Neurological soft signs are increased in migraine without aura: relationship with the affective status
Authors: Tremolizzo Lucio , Selvatico Daniele , Pozzi Federico Emanuele , Cereda Diletta , DiFrancesco Jacopo Cosimo , Fumagalli Lorenzo , Ferrarese Carlo , Appollonio Ildebrando
Published: May 2022

Introduction

Neurological soft signs (NSS) are subtle non-localizing sensorimotor abnormalities initially reported as increased in primary headache patients. The aims of this study were confirming with full power NSS increased expression in migraine and, collaterally, determining if psychiatric traits or white matter lesions at brain imaging could influence this result.

Methods

Forty drug-free episodic migraine outpatients (MH) were recruited with 40 matched controls. NSS were determined by the 16-item Heidelberg scale; depression, anxiety and QoL by the HAM-D; the STAI-X1/X2; and the SF36, respectively. The Fazekas scale on brain MR studies was applied in n = 32 MH, unravelling deep white matter signal alterations (DWM). MH characteristics, including the headache disability inventory (HDI), were recorded.

Results

NSS were 46% increased in MH vs. controls (p = 0.0001). HAM-D and STAI-X1/X2 were increased in MH, while SF36 was unchanged, but they all failed to influence NSS, just as MH characteristics. NSS scores were increased in MH-DWM + (n = 11, + 85%) vs. MH-DWM − (n = 21, + 27%) vs. controls (p < 0.0001). NSS increased expression in MH was influenced by DWM, while psychiatric traits and headache characteristics failed to do so.

Discussion/conclusions

NSS are increased in MH and probably not influenced by the affective status, possibly marking a dysfunction within the cerebellar-thalamic-prefrontal circuit that may deserve further attention from the prognostic point of view.
Bifunctional catalysts for heterogeneous electro-Fenton processes: a review
Authors: Yao Yuanyuan , Pan Yuqi , Yu Yanxi , Yu Zixun , Lai Leo , Liu Fangzhou , Wei Li , Chen Yuan
Published: May 2022

Fenton processes allow to degrade and mineralize toxic organic contaminants, yet classical Fenton processes require continuously adding hydrogen peroxide and ferrous ions, costly solution pH adjustment, and treatment of secondary iron sludge pollution. Heterogeneous electro-Fenton processes deliver oxidizing radicals with only oxygen and electricity consumed. Bifunctional catalysts allow the synthesis and activation of hydrogen peroxide simultaneously, eliminate additional chemical reagents, and yield no metal residues in treated water. Here, we review bifunctional catalysts for heterogeneous electro-Fenton processes. We describe the mechanisms of oxidizing radical generation from oxygen. Then, we compare different types of bifunctional catalysts based on their elemental compositions: (1) metal/carbon composite catalysts, i.e., monometallic iron/carbon composite catalysts, bimetallic/trimetallic carbon composite catalysts, and transition metal single-atom catalysts; (2) metal composite catalysts without carbon; and (3) metal-free carbon catalysts. Then, we present five other approaches beyond electrocatalysts, which have been used to improve the performance of heterogeneous electro-Fenton processes.
“Change Doesn’t Happen by Itself”: A Thematic Analysis of First-Level Leaders’ Experiences Participating in the Leadership and Organizational Change for Implementation (LOCI) Strategy
Authors: Borge Randi Hovden , Egeland Karina M. , Aarons Gregory A. , Ehrhart Mark G. , Sklar Marisa , Skar Ane-Marthe Solheim
Published: May 2022

The Leadership and Organizational Change for Implementation (LOCI) strategy is a multifaceted implementation strategy that aims to support successful evidence-based practice (EBP) implementation by fostering effective general leadership, implementation leadership, and implementation climate. How implementation strategies are experienced by participants is important for their utilization and effectiveness in supporting EBP implementation. The current study is the first in-depth qualitative study exploring first-level leaders’ experiences of participating in the LOCI strategy. Data were collected as part of a trial where Norwegian child and adult mental health outpatient clinics implemented EBPs for posttraumatic stress disorder (PTSD). Eleven first-level leaders from adult and child clinics participated in semi-structured interviews after completing the LOCI strategy. Data were analyzed through reflexive thematic analysis. The analysis generated four themes related to leaders’ experiences of participating in the LOCI strategy: (1) structuring the EBP implementation, (2) taking responsibility for the EBP implementation, (3) interacting with others about the EBP implementation, and (4) becoming aware of EBP implementation and their own leadership. Most participants experienced the LOCI strategy as beneficial for implementing EBPs for PTSD in their clinic. The strategy succeeded in raising awareness of leadership for EBP implementation, and simultaneously provided participants with tools and support for leading the implementation in their clinic. Two participants experienced LOCI as less beneficial than the others. Our results support the strategy’s potential to engage and empower first-level leaders to get involved in implementation processes and point to important challenges for future research on implementation strategies.
Well-posedness and numerical schemes for one-dimensional McKean–Vlasov equations and interacting particle systems with discontinuous drift
Authors: Leobacher Gunther , Reisinger Christoph , Stockinger Wolfgang
Published: May 2022

In this paper, we first establish well-posedness results for one-dimensional McKean–Vlasov stochastic differential equations (SDEs) and related particle systems with a measure-dependent drift coefficient that is discontinuous in the spatial component, and a diffusion coefficient which is a Lipschitz function of the state only. We only require a fairly mild condition on the diffusion coefficient, namely to be non-zero in a point of discontinuity of the drift, while we need to impose certain structural assumptions on the measure-dependence of the drift. Second, we study Euler–Maruyama type schemes for the particle system to approximate the solution of the one-dimensional McKean–Vlasov SDE. Here, we will prove strong convergence results in terms of the number of time-steps and number of particles. Due to the discontinuity of the drift, the convergence analysis is non-standard and the usual strong convergence order 1/2 known for the Lipschitz case cannot be recovered for all presented schemes.
Modelling the effects of climate change on the profitability of Australian farms
Authors: Hughes Neal , Lu Michael , Soh Wei Ying , Lawson Kenton
Published: May 2022

Recent shifts in the Australian climate including both higher temperatures and lower winter rainfall have had significant effects on the agriculture sector. Despite these recent trends, there remains uncertainty over the future climate and its potential impacts on Australian farm businesses. In this study, a statistical model of Australian cropping and livestock farms is combined with downscaled temperature and rainfall projections for 2050, to simulate the effects of climate change on farm profits. These future projections are compared against both a historical reference climate (1950 to 2000) and recent conditions (2001 to 2020). The results provide an indication of ‘adaptation pressure’: showing which regions, sectors and farm types may be under greater pressure to adapt or adjust to climate change. Future scenarios produce a wide range of outcomes, with simulated change in average farm profits (without any long-run adaptation or technological advance) ranging from −2 to -32% under RCP4.5 and −11 to −50% under RCP8.5, compared with a decline of 22.3% under observed post-2000 conditions (all relative to 1950 to 2000 climate). In contrast with the recent observed changes, projections show relatively moderate effects in south-eastern Australia, but relatively stronger effects for livestock farms in northern Australia.
Organizational Change in Complex Systems: Organizational and Leadership Factors in the Introduction of Open Dialogue to Mental Health Care Services
Authors: Lennon Elizabeth , Hopkins Liza , Einboden Rochelle , McCloughen Andrea , Dawson Lisa , Buus Niels
Published: May 2022

Conventional mental health services are frequently criticized for failing to support people and communities in their care. Open Dialogue is a non-conventional humanistic approach to mental health care, which has been implemented in many different settings globally. At two Australian public health care services, implementation of the approach led to positive client outcomes and sustained organizational and clinical change. The aim of the study was to identify and explore the organizational, management, leadership and cultural factors that contributed to sustained implementation in these complex systems. We conducted nine individual semi-structured interviews of health care leaders and managers from the two sites. Transcriptions of the interviews were analyzed thematically. Leaders facilitated a gradual development of clinical and organizational legitimacy for the non-standardized Open Dialogue approach by holding the anxiety and frustration of practitioners and parts of the administration, cultivating cultural change and adaptation and by continually removing organizational obstacles.
Sulfur analyses and mineralogical data in the preliminary mine waste characterization
Authors: Karlsson Teemu , Kauppila Päivi M. , Lehtonen Marja , Alakangas Lena , Kauppila Tommi
Published: May 2022

The objective of this study was to investigate the use of the acid production potential (AP) calculation factor and seven different S analysis methods in the preliminary mine waste characterization by analyzing and comparing 48 Finnish mine waste samples. Special attention was paid on mineralogical aspects and data produced in the exploration phase of a mining project.

According to our results, the abundance of sulfide species other than pyrite in Finnish mine waste suggests that the factor to calculate the AP should be considered based on mineralogy and would often be below 31.25. Therefore, the mineralogy-based determination of S should be preferred. However, the determination of S based on scanning electron microscope (SEM) mineralogy includes some uncertainties. Underestimation of S content may appear if not all S-bearing mineral particles have been detected, or if the amount of S is low in general. This uncertainty appears to be especially related to the samples containing elevated (> 9 wt%) amounts of serpentine, diopside, augite, and/or hornblende. Risk of overestimating AP is related to samples containing high amounts (> 4.13 wt%) of S-bearing minerals. These uncertainties can be reduced by inspecting that the SEM mineralogy-based S concentrations are in line with the energy dispersive X-ray spectrometer data. The aqua regia extractable S concentrations, which are often available in the exploration phase, appeared to be usable in the preliminary waste rock AP assessment and often comparable with the analytical total S values in the Finnish waste rock samples, especially when the samples did not contain any sulfate minerals. In contrast, the analytical sulfide S and the X-ray fluorescence methods may lead to an underestimation of AP.
What Matters More, Perceived or Real Crime?
Authors: Manning Matthew , Fleming Christopher M. , Pham Hien-Thuc , Wong Gabriel T. W.
Published: May 2022

Crime consistently penetrates public and political debate, where crime, either perceived or real, shapes one’s sense of security, safety and wellbeing. This matters, as the perceived versus real dilemma influences policy decisions. But what matters most? Here the evidence is mixed with often highly inconsistent findings. Against this background, and employing more recent and arguably more robust econometric models, we compare the effect of real crime and perceived crime on self-reported life satisfaction after controlling for the effect of victimisation. We also explore the heterogenous effects of real crime and perceived crime among different socioeconomic and demographic groups. Overall, our results, across all model specifications, demonstrate that perceived crime always matters, while real crime only matters to those on high-incomes. We also find that females tend to be more sensitive to their perceptions, while living outside major cities does not have a significant effect. Our results support our belief that more should be done to reduce the misperceptions of crime. Further, public media coverage related to crime should be more objective and informative to avoid inflating misperceptions and public distress.
Does sentence length affect the risk for criminal recidivism? A quasi-experimental study of three policy reforms in Sweden
Authors: Al Weswasi Enes , Sivertsson Fredrik , Bäckman Olof , Nilsson Anders
Published: May 2022

Objectives

This study examines the relationship between incarceration time and post-release recidivism among first-time incarcerated adult offenders.

Methods

A quasi-experimental design was adopted consisting of three policy reforms that were treated as separate natural experiments. While holding imposed sentence length constant, these policy reforms either decreased or increased the required share of a sentence inmates needed to be incarcerated before being eligible for parole. Data consisted of large-scale administrative records containing all convictions for the Swedish cohorts born in 1958 and later.

Results

Results indicate that neither increased nor decreased incarceration time had a statistically significant effect on post-release recidivism, irrespective of how recidivism was measured.

Conclusions

Findings reveal little evidence for incarceration time having a criminogenic or specific preventive effect on post-release recidivism.
Electromyographic and kinematic evaluation of bench press exercise: a case report study on athletes with different impairments and expertise
Authors: Bellitto Amy , Marchesi Giorgia , Comini Micaela , Massone Antonino , Casadio Maura , De Luca Alice
Published: May 2022

Purpose

With an increase in the number of adapted sports, the need to monitor sports performance in people with different abilities has grown. Indeed, a thorough evaluation of the sports gesture could prevent the occurrence of injuries, enable a continuous performance assessment, and allow to verify the compliance of the requirements for the competitions. Gesture kinematics provides an assessment of performance, while the muscle activities reveal the underlying strategies adopted by each athlete. In this context, we propose an instrumented evaluation to assess performance in Para-powerlifting. Our goal is to define and test a setup and a protocol to quantitatively assess the execution of bench press exercise in athletes with different abilities.

Methods

We recruited an unimpaired athlete and three Paralympic athletes. They were requested to execute the bench press exercise while we recorded muscle activity and kinematic data from the upper body. We investigated the sport gesture by extracting parameters describing coordination, symmetry, and synchronism between arms, and motor variability while repeating the gesture.

Results

Paralympic athletes performed the gestures with higher coordination between arms and low variability across repetitions compared to the unimpaired athlete, who was not at the Olympic level. All participants obtained similar kinematic performance by adopting different muscle strategies.

Conclusions

This study is a proof of concept that the instrumented evaluation proposed here can allow to conduct a complete assessment of the bench press exercise, in terms of kinematics, muscle activity and performance in athletes with different abilities.
Antimicrobial resistance genes in microbiota associated with sediments and water from the Akaki river in Ethiopia
Authors: Yitayew Berhanu , Woldeamanuel Yimtubezinash , Asrat Daniel , Rahman Aminur , Mihret Adane , Aseffa Abraham , Olsson Per-Erik , Jass Jana
Published: May 2022

The spread of antimicrobial-resistant pathogens is a global health concern. Most studies report high levels of antimicrobial resistance genes (ARGs) in the aquatic environment; however, levels associated with sediments are limited. This study aimed to investigate the distribution of ARGs in the sediments and water of the Akaki river in Addis Ababa, Ethiopia. The diversity and abundance of 84 ARGs and 116 clinically important bacteria were evaluated from the sediments and water collected from five sites in the Akaki river. Most of the ARGs were found in the city close to anthropogenic activities. Water samples collected in the middle catchment of the river contained 71–75% of targeted ARGs, with genes encoding aminoglycoside acetyltransferase (aac(6)-Ib-cr), aminoglycoside adenylyl transferase (aadA1), β-lactamase (blaOXA-10), quinolone resistance S (qnrS), macrolide efflux protein A (mefA), and tetracycline resistance (tetA), were detected at all sampling sites. Much fewer ARGs were detected in all sediments, and those near the hospitals had the highest diversity and level. Despite the lower levels and diversity, there were no unique ARGs detected in the sediments that were also not detected in the waters. A wide range of clinically relevant pathogens were also detected in the Akaki river. The findings suggest that the water phase, rather than the sediments in the Akaki river, is a potential conduit for the spread of ARGs and antibiotic-resistant bacteria.
A Coaxial Wire-Feed Additive Manufacturing of Metal Components Using a Profile Electron Beam in Space Application
Authors: Kovalchuk Dmytro , Melnyk Vitalii , Melnyk Ihor
Published: May 2022

Despite the variety of different methods of metal 3D printing on Earth, only a few of them can be realized in space. Processes that employ electron beam as a heat source and wire as a consumable material is among the most promising methods for these applications. But to date, such processes still have not been implemented in actual space operation, mainly due to the low accuracy and resolution of these 3D printed products that require significant post-processing for their intended use. Large and heavy hardware employed in these processes is another significant problem. xBeam 3D Metal Printing is the electron beam DED-wire additive manufacturing technology that has already demonstrated the capability to produce high-quality parts with high productivity on terrestrial relatively lightweight and compact hardware. xBeam process employs a profile electron beam generated by low-voltage gas-discharge electron beam guns combined with the coaxial wire feed to provide excellent control of metallurgy processes in the melt pool and around it during deposition. Realized metallurgy conditions are the crucial factor in providing the combination of high accuracy and resolution with good metal structure and properties. Moreover, maintaining such metallurgy conditions does not require gravity—only cohesion/adhesion forces and surface tension forces are involved. This fact suggests good prospects for using the xBeam 3D Metal Printing in space applications. In addition, the method opens several unique technological opportunities that are important in space exploration, including the nonstick deposition technique allowing the production of "ready-to-use" parts, surface glazing able to substitute machining, recycling of the metal waste directly into wire for 3D printing, and others. The article presents technical solutions for implementing 3D printing and related processes in space conditions and analyzes the metallurgical aspects of the technology using titanium alloy Ti-6Al-4V as an example.
Theoretical and experimental study on the fluidity performance of hard-to-fluidize carbon nanotubes-based CO2 capture sorbents
Authors: Nobarzad Mahsa Javidi , Tahmasebpoor Maryam , Heidari Mohammad , Pevida Covadonga
Published: May 2022

Carbon nanotubes-based materials have been identified as promising sorbents for efficient CO2 capture in fluidized beds, suffering from insufficient contact with CO2 for the high-level CO2 capture capacity. This study focuses on promoting the fluidizability of hard-to-fluidize pure and synthesized silica-coated amine-functionalized carbon nanotubes. The novel synthesized sorbent presents a superior sorption capacity of about 25 times higher than pure carbon nanotubes during 5 consecutive adsorption/regeneration cycles. The low-cost fluidizable-SiO2 nanoparticles are used as assistant material to improve the fluidity of carbon nanotubes-based sorbents. Results reveal that a minimum amount of 7.5 and 5 wt% SiO2 nanoparticles are required to achieve an agglomerate particulate fluidization behavior for pure and synthesized carbon nanotubes, respectively. Pure carbon nanotubes + 7.5 wt% SiO2 and synthesized carbon nanotubes + 5 wt% SiO2 indicates an agglomerate particulate fluidization characteristic, including the high-level bed expansion ratio, low minimum fluidization velocity (1.5 and 1.6 cms−1), high Richardson—Zaki n index (5.2 and 5.3 > 5), and low Π value (83.2 and 84.8 < 100, respectively). Chemical modification of carbon nanotubes causes not only enhanced CO2 uptake capacity but also decreases the required amount of silica additive to reach a homogeneous fluidization behavior for synthesized carbon nanotubes sorbent.
Zur Verwendung projektiver Verfahren in der Familienrechtspsychologie: ein Diskussionsbeitrag
Authors: Neuerburg Charis R. , Banse Rainer
Published: May 2022

Projektive Verfahren werden auch heute noch in der familienrechtspsychologischen Diagnostik eingesetzt. Erfahrungsgemäß lassen sich 3 unterschiedliche Anwendungsarten unterscheiden: a) als klassisch diagnostisches Instrument, b) als informelle Verhaltensprobe oder c) als Explorationshilfe bzw. Gesprächseinstieg. In der folgenden Übersicht werden diese 3 Anwendungsarten dargestellt sowie ihr Nutzen für die familienrechtspsychologische Diagnostik kritisch diskutiert. Hierfür wird zunächst ein Überblick über die empirische Fundierung der am meisten genutzten projektiven Verfahren (des Thematischen Apperzeptionstests und zeichnerische Verfahren allgemein) gegeben. Es wird dann diskutiert, ob die klassischen psychometrischen Gütekriterien auf projektive Verfahren anwendbar sind. Hinsichtlich der Verwendung projektiver Verfahren als informelle Verhaltensprobe wird auf mögliche Urteilsverzerrungen hingewiesen, insbesondere den „confirmation bias“, den Effekt der illusorischen Korrelation und den möglichen Einfluss irrelevanter Informationen auf den diagnostischen Prozess. Angesichts der potenziell negativen Auswirkungen auf die Validität der Diagnostik empfehlen wir, projektive Verfahren nicht in der Einzelfalldiagnostik einzusetzen, wenn keine direkten empirischen Belege für die Validität des spezifischen Verfahrens für die genutzte Auswertungsart und das zu diagnostizierende Konstrukt vorliegen.
FGF/FGFR signaling in adrenocortical development and tumorigenesis: novel potential therapeutic targets in adrenocortical carcinoma
Authors: Tamburello Mariangela , Altieri Barbara , Sbiera Iuliu , Sigala Sandra , Berruti Alfredo , Fassnacht Martin , Sbiera Silviu
Published: May 2022

FGF/FGFR signaling regulates embryogenesis, angiogenesis, tissue homeostasis and wound repair by modulating proliferation, differentiation, survival, migration and metabolism of target cells. Understandably, compelling evidence for deregulated FGF signaling in the development and progression of different types of tumors continue to emerge and FGFR inhibitors arise as potential targeted therapeutic agents, particularly in tumors harboring aberrant FGFR signaling. There is first evidence of a dual role of the FGF/FGFR system in both organogenesis and tumorigenesis, of which this review aims to provide an overview. FGF-1 and FGF-2 are expressed in the adrenal cortex and are the most powerful mitogens for adrenocortical cells. Physiologically, they are involved in development and maintenance of the adrenal gland and bind to a family of four tyrosine kinase receptors, among which FGFR1 and FGFR4 are the most strongly expressed in the adrenal cortex. The repeatedly proven overexpression of these two FGFRs also in adrenocortical cancer is thus likely a sign of their participation in proliferation and vascularization, though the exact downstream mechanisms are not yet elucidated. Thus, FGFRs potentially offer novel therapeutic targets also for adrenocortical carcinoma, a type of cancer resistant to conventional antimitotic agents.
Minocycline Attenuates Microglia/Macrophage Phagocytic Activity and Inhibits SAH-Induced Neuronal Cell Death and Inflammation
Authors: Blecharz-Lang Kinga G. , Patsouris Victor , Nieminen-Kelhä Melina , Seiffert Stefanie , Schneider Ulf C. , Vajkoczy Peter
Published: May 2022

Background

Neuroprotective treatment strategies aiming at interfering with either inflammation or cell death indicate the importance of these mechanisms in the development of brain injury after subarachnoid hemorrhage (SAH). This study was undertaken to evaluate the influence of minocycline on microglia/macrophage cell activity and its neuroprotective and anti-inflammatory impact 14 days after aneurismal SAH in mice.

Methods

Endovascular filament perforation was used to induce SAH in mice. SAH + vehicle-operated mice were used as controls for SAH vehicle-treated mice and SAH + minocycline-treated mice. The drug administration started 4 h after SAH induction and was daily repeated until day 7 post SAH and continued until day 14 every second day. Brain cryosections were immunolabeled for Iba1 to detect microglia/macrophages and NeuN to visualize neurons. Phagocytosis assay was performed to determine the microglia/macrophage activity status. Apoptotic cells were stained using terminal deoxyuridine triphosphate nick end labeling. Real-time quantitative polymerase chain reaction was used to estimate cytokine gene expression.

Results

We observed a significantly reduced phagocytic activity of microglia/macrophages accompanied by a lowered spatial interaction with neurons and reduced neuronal apoptosis achieved by minocycline administration after SAH. Moreover, the SAH-induced overexpression of pro-inflammatory cytokines and neuronal cell death was markedly attenuated by the compound.

Conclusions

Minocycline treatment may be implicated as a therapeutic approach with long-term benefits in the management of secondary brain injury after SAH in a clinically relevant time window.
The historical nature of biological complexity and the ineffectiveness of the mathematical approach to it
Authors: Forestiero Saverio
Published: May 2022

Contemporary scientific knowledge is built on both methodological and epistemological reductionism. The discovery of the limitations of the reductionist paradigm in the mathematical treatment of certain physical phenomena originated the notion of complexity, both as a pattern and process. After clarifying some very general terms and ideas on biological evolution and biological complexity, the article will tackle to seek to summarize the debate on biological complexity and discuss the difference between complexities of living and inert matter. Some examples of the major successes of mathematics applied to biological problems will follow; the notion of an intrinsic limitation in the application of mathematics to biological complexity as a global, relational, and historical phenomenon at the individual and species level will also be advanced.
Perceiving refugees as threats may backfire on one’s health: Relations with intercultural antecedents and psychological distress among Germans
Authors: Schubert Saskia , Mahat-Shamir Michal , Hamama-Raz Yaira , Ringeisen Tobias
Published: May 2022

In the recent years, research on the conditions, under which members of the host countries such as Germany perceive refugees as threatening and respond with negative attitudes, has increased. However, little attention has been given to the implications that subjective perceptions of threat among the host community may have for their own psychological health. Using integrated threat theory, the current study examined the relationships between perceived threats, person-centered antecedents in intercultural settings, and psychological distress among Germans, who reflected on incoming refugees. Using a survey company, a sample (N = 1000) was recruited, which matched the German census regarding central demographics. Participants completed a cross-sectional online survey with validated self-report measures. Assessments covered four perceived threat types (intergroup anxiety, symbolic and realistic threat, negative stereotypes), person-related antecedents (social identity as German, quantity and quality of prior intercultural contact), and psychological distress. Applying structural equation modeling, we found that high social identification as German was related to greater perceptions of symbolic/realistic threat, stronger negative stereotypes and to more intergroup anxiety. Vice versa, high quality of prior intercultural contact experiences was associated with a decrease of all threat types. The quantity of prior intercultural contact showed almost no relations to perceived threats. In terms of indirect effects, greater quality of contact predicted less distress, and greater identity as German predicted more distress, both via symbolic/realistic threat and intergroup anxiety. Taken together, perceiving refugees as a threatening outgroup may signify a self-harming risk, while high quality of intercultural relations may indirectly enhance health.
Optical metalenses: fundamentals, dispersion manipulation, and applications
Authors: He Yongli , Song Boxiang , Tang Jiang
Published: May 2022

Metasurfaces, also known as 2D artificial metamaterials, are attracting great attention due to their unprecedented performances and functionalities that are hard to achieve by conventional diffractive or refractive elements. With their sub-wavelength optical scatterers, metasurfaces have been utilized to freely modify different characteristics of incident light such as amplitude, polarization, phase, and frequency. Compared to traditional bulky lenses, metasurface lenses possess the advantages of flatness, light weight, and compatibility with semiconductor manufacture technology. They have been widely applied to a range of scenarios including imaging, solar energy harvesting, optoelectronic detection, etc. In this review, we will first introduce the fundamental design principles for metalens, and then report recent theoretical and experimental progress with emphasis on methods to correct chromatic and monochromatic aberrations. Finally, typical applications of metalenses and corresponding design rules will be presented, followed by a brief outlook on the prospects and challenges of this field.

Graphical abstract
Ti6Al4V/SiC Metal Matrix Composites Additively Manufactured by Direct Laser Deposition
Authors: de Rojas Candela C. Sánchez , Riquelme A. , Bonache V. , Rodrigo P. , Rams J.
Published: May 2022

Nowadays, research on additive manufacturing of Ti6Al4V alloy is growing exponentially but there are just a few studies about additive manufacturing of metal matrix composite components. In this work, highly reinforced Ti6Al4V matrix composites with SiC particles have been additively manufactured by direct laser deposition (DLD). Ti6Al4V powder and SiC particles have been deposited layer by layer to form an additive thin wall structure. The geometry, microstructure, and microhardness of the samples are strongly influenced by the laser scanning speed used during de fabrication process. In addition, the effect of the SiC increment in reinforcement concentrations and the influence of SiC particle sizes in the microstructure have been evaluated, and the reaction mechanisms have been established. The percentage of reinforcement measured is lower than expected due to the reinforcement-matrix reactivity that results in partially dissolved SiC particles and the formation of a TiC and Si5Ti3 ring around them. The size and number of particles and reaction products depend on the initial size and percentage of reinforcement and the DLD scanning speed. The higher the size and percentage of SiC particles and reaction products in the matrix, the higher the hardening effect of the composite matrix.

Graphic Abstract
Transferwissen von Lehrenden in der berufsbezogenen Weiterbildung: Entwicklung und Pilotierung eines Testinstruments
Authors: Koch Alisha , Wißhak Susanne , Spener Claudio , Naumann Alexander , Hochholdinger Sabine
Published: May 2022

Transfer gilt als zentrales Ziel berufsbezogener Weiterbildungsmaßnahmen. Obwohl Lehrende in der berufsbezogenen Weiterbildung Transfer anbahnen und unterstützen können, ist über ihr dafür benötigtes professionelles Wissen bislang wenig bekannt, und es fehlt an einem Messinstrument zu dessen Erfassung. Zu diesem Zweck entwickelten wir einen Test, welcher wissenschaftlich fundiertes Wissen über die Determinanten und die Förderung von Transfer erfasst. Der vorliegende Beitrag thematisiert die Entwicklung und Pilotierung des Instruments. Auf Basis der Item-Response-Theory (IRT) wurden die Testantworten von N = 105 Lehrenden skaliert und interpretiert. Die 32 Items zeigen eine gute Passung hinsichtlich des eindimensionalen Partial-Credit-Modells mit Infit-Werten zwischen 0,93 und 1,16. Die EAP/PV-Reliabilität liegt bei 0,81. Die Ergebnisse weisen darauf hin, dass sich Transferwissen mithilfe des Instruments operationalisieren und reliabel messen lässt.
Constructing all genus 2 curves with supersingular Jacobian
Authors: Pieper Andreas
Published: May 2022

L. Moret-Bailly constructed families $${\mathfrak {C}}\rightarrow {\mathbb {P}}^1$$

C
→

P

1

of genus 2 curves with supersingular Jacobian. In this paper we first classify the reducible fibers of a Moret-Bailly family using linear algebra over a quaternion algebra. The main result is an algorithm that exploits properties of two reducible fibers to compute a hyperelliptic model for any irreducible fiber of a Moret-Bailly family.
A network analysis to identify lung cancer comorbid diseases
Authors: Rustamaji Heru C. , Suharini Yustina S. , Permana Angga A. , Kusuma Wisnu A. , Nurdiati Sri , Batubara Irmanida , Djatna Taufik
Published: May 2022

Cancer patients with comorbidities face various life problems, health costs, and quality of life. Therefore, determining comorbid diseases would significantly affect the treatment of cancer patients. Because cancer disease is very complex, we can represent the relationship between cancer and its comorbidities as a network. Furthermore, the network analysis can be employed to determine comorbidities as a community detection problem because the relationship between cancer and its comorbidities forms a community. This study investigates which community detection algorithms are more appropriate to determine the comorbid of cancer. Given different community findings, this study attempted to analyze the modularity generated by the algorithm to decide the significant comorbid diseases. We retrieved lung cancer comorbid data on the basis of text mining manuscripts in PubMed, searched through disease ontologies, and calculated disease similarity. We investigate 20 algorithms using five modularity metrics and 16 fitness function evaluations to determine the significant comorbid diseases. The results show the five best modularity algorithms, namely label propagation, spinglass, Chinese whispers, Louvain, RB Pots. These five algorithms found significant comorbidities: blood vessels, immune system, bone, pancreas, and metabolic disorders, atrial cardiac septal defect, atrial fibrillation respiratory system, interstitial lung, and diabetes mellitus. The fitness function justifies the results of the community algorithm, and the ones that have a significant effect are average internal degree, size, and edges inside. This study contributes to more comprehensive knowledge and management of diseases in the healthcare context.
Use of lures with a mix of sweet and fetid odors for catching Musca domestica L. in domestic environments
Authors: Guarino Salvatore , Caimi Marco , Abdulsattar Arif Mokhtar , Zito Pietro
Published: May 2022

The housefly, Musca domestica L. (Diptera; Muscidae), is an insect closely associated with human activities in urban and rural environments and is thus a crucial factor in the transmission of various fecal–oral pathogens. The use of traps for monitoring and controlling these species in indoors is often limited by the fetid nature of the chemical attractants commonly used. A recent study demonstrated the attraction of houseflies to terpenoids, which are perceived by humans as a sweet odor. The aim of this study was to test pleasant smelling compounds such as terpinolene, α-terpinene and linalool mixed with others (acetic, butyric, isovaleric and hexanoic acid, indole and dimethyl trisulfide) known to attract houseflies to obtain a lure that could be acceptable in domestic environments. Experiments were carried out in the laboratory, using olfactometer, and in two rooms of 32 m3 and 108 m3, each resembling domestic environments using trap bioassays. The results showed that the volatile blend tested elicited attraction in the olfactometer and increased the number of flies captured by the traps. In the smaller room, the lure demonstrated efficacy for two weeks from the start of the experiment, while in the larger room the number of captured flies was higher than in the control traps only during the first week. The results confirmed the attraction of the flies to the traps baited with the blend, the application of the lures in domestic environments can be taken into consideration as a new alternative tool for trapping this pest.
Writing assessment in early primary classrooms: thoughts from four teachers
Authors: Mariano Elle , Campbell-Evans Glenda , Hunter Janet
Published: May 2022

It is important that teachers are conscious of and reflect upon their views of writing in order to support students to achieve writing outcomes. This study examined teacher views about which aspects of writing they considered most important in years one and two and explored how these views came to be formed. Four West Australian teachers participated in semi-structured interviews, during which they carried out a think-aloud process, voicing their thoughts as they examined, commented on, and evaluated young students’ writing samples. These data provided insights into their reasoning as they assessed children’s writing in years one and two. Findings revealed that participants focussed on the more surface-level, or secretarial aspects of writing, such as punctuation and ‘correct’ structure for the genre. The data indicated that teachers were particularly influenced by their knowledge of the contexts in which they worked, including knowledge they shared with colleagues, together with curriculum and systemic documents such as the Judging Standards materials supplied by the School Curriculum and Standards Authority (SCSA) or the NAPLAN marking guides. These results highlight how systemic assessments can shape teacher perceptions of writing more generally than the purpose for which they were originally intended.
Transition to school: children’s perspectives of the literacy experiences on offer as they move from pre-school to the first year of formal schooling
Authors: Cronin Lynette Patricia , Kervin Lisa , Mantei Jessica
Published: May 2022

The importance of children experiencing a successful transition to school is well established in research literature. Central to this is including the children themselves in the conversation about their learning and ensuring they develop a sense of fit and belonging to their new school environment. The findings shared in this paper sit within a larger study of examining children’s perspectives of their literacy experiences at the time of transition to school. This paper reports the perspectives of two children, firstly in their pre-school (prior-to-school) setting and then again in their Kindergarten setting (the first year of formal primary schooling in New South Wales). The study draws on the theories of literacy as a social practice and describes literacy as events and practices. Digital storytelling was used as the main data collection method to capture the children’s voices as they annotate images, describing their chosen literacy events in each educational setting. Findings revealed that whilst some children have a confident and successful initiation into the literacy events and practices of school, others may not. Herein are substantial messages, firstly, that we need to listen to children so we can support their transition to formal school and secondly that teachers need to better understand the literacy practices of children in pre-school to more effectively support them as they transition to Kindergarten.
A Corporate Governance Approach to Cybersecurity Risk Disclosure
Authors: Kiesow Cortez Elif , Dekker Martijn
Published: May 2022

This article sheds light on cybersecurity risk disclosure practices, offering explanations based on the corporate governance literature. We argue that cybersecurity risk management poses particular challenges for corporations due to amplified agency problems. Cybersecurity risks are increasing in number and growing in complexity for companies worldwide. The financial sector in the Benelux region was already digitalising rapidly when, in 2020, enhanced remote-working requirements due to the COVID-19 pandemic further contributed to risk exposure. Substantiating our theoretical discussion, we present and discuss insights as to the most pressing cybersecurity risk management issues in the financial sector based on evidence from semi-structured interviews with Chief Information Security Officers/Chief Security Officers from financial sector leads in the Benelux region. We discuss contemporary factors that might induce management to dedicate more attention to cybersecurity. This apparent shift in companies’ approaches regarding cybersecurity is likely to encounter obstacles and should not be expected to be an even and linear process, given the challenges of processing and communicating information in an environment featuring high uncertainty and technical complexity as well as potentially misaligned incentives.
Bubble rise in a Hele-Shaw cell: bridging the gap between viscous and inertial regimes
Authors: Monnet Benjamin , Madec Christopher , Vidal Valérie , Joubaud Sylvain , John Soundar Jerome J.
Published: May 2022

The rise of a single bubble confined between two vertical plates is investigated over a wide range of Reynolds numbers. In particular, we focus on the evolution of the bubble speed, aspect ratio and drag coefficient during the transition from the viscous to the inertial regime. For sufficiently large bubbles, a simple model based on power balance captures the transition for the bubble velocity and matches all the experimental data despite strong time variations of bubble aspect ratio at large Reynolds numbers. Surprisingly, bubbles in the viscous regime systematically exhibit an ellipse elongated along its direction of motion while bubbles in the inertia-dominated regime are always flattened perpendicularly to it.
On the nonlinear viscosity of the orthotropic bulk rheology
Authors: Rathmann Nicholas M. , Lilien David A.
Published: May 2022

We compare different ways the bulk flow nonlinearity of glacier ice can be captured in an orthotropic rheology. Specifically, we compare the unapproximated orthotropic rheology, derived from plastic potential theory, to existing approximations that assume either the nonlinear viscosity or fluidity is identical to that of Glen's isotropic flow law. We find, overall, a reasonable agreement between the three orthotropic rheologies, and with existing Dye 3 ice-core deformation tests, although assuming Glen's viscosity provides the best approximation to the unapproximated rheology. Our results therefore suggest that previous studies based on either approximation to the orthotropic rheology are on relatively safe ground in the sense that both approximations generally agree with the unapproximated rheology and experimental data. Finally, we provide the forward and inverse analytical forms of all three rheologies for use in future numerical ice-flow modelling.