bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Clinical Features of Hospitalized Patients Due to the SARS-CoV-2 Infection in the Absence of Comorbidities Regarding the Sex: An Epidemiological Study of the First Year of the Pandemic in Brazil
Authors: Sansone Nathália Mariana Santos , Pereira Letícia Rogini , Boschiero Matheus Negri , Valencise Felipe Eduardo , Fraga Andréa Melo Alexandre , Marson Fernando Augusto Lima
Published: July 2022

The male sex, due to the presence of genetic, immunological, hormonal, social, and environmental factors, is associated with higher severity and death in Coronavirus Disease (COVID)-19. We conducted an epidemiological study to characterize the COVID-19 clinical profile, severity, and outcome according to sex in patients with the severe acute respiratory syndrome (SARS) due to the fact of this disease. We carried out an epidemiological analysis using epidemiological data made available by the OpenDataSUS, which stores information about SARS in Brazil. We recorded the features of the patients admitted to the hospital for SARS treatment due to the presence of COVID-19 (in the absence of comorbidities) and associated these characteristics with sex and risk of death. The study comprised 336,463 patients, 213,151 of whom were men. Male patients presented a higher number of clinical signs, for example, fever (OR = 1.424; 95%CI = 1.399–1.448), peripheral arterial oxygen saturation (SpO2) < 95% (OR = 1.253; 95%CI = 1.232–1.274), and dyspnea (OR = 1.146; 95%CI = 1.125–1.166) as well as greater need for admission in intensive care unit (ICU, OR = 1.189; 95%CI = 1.168–1.210), and the use of invasive ventilatory support (OR = 1.306; 95%CI = 1.273–1.339) and noninvasive ventilatory support (OR = 1.238; 95%CI = 1.216–1.260) when compared with female patients. Curiously, the male sex was associated only with a small increase in the risk of death when compared with the female sex (OR = 1.041; 95%CI = 1.023–1.060). We did a secondary analysis to identify the main predictors of death. In that sense, the multivariate analysis enabled the prediction of the risk of death, and the male sex was one of the predictors (OR = 1.101; 95%CI = 1.011–1.199); however, with a small effect size. In addition, other factors also contributed to this prediction and presented a great effect size, they are listed below: older age (61–72 years old (OR = 15.778; 95%CI = 1.865–133.492), 73–85 years old (OR = 31.978; 95%CI = 3.779–270.600), and +85 years old (OR = 68.385; 95%CI = 8.164–589.705)); race (Black (OR = 1.247; 95%CI = 1.016–1.531), Pardos (multiracial background; OR = 1.585; 95%CI = 1.450–1.732), and Indigenous (OR = 3.186; 95%CI = 1.927–5.266)); clinical signs (for instance, dyspnea (OR = 1.231; 95%CI = 1.110–1.365) and SpO2 < 95% (OR = 1.367; 95%CI = 1.238–1.508)); need for admission in the ICU (OR = 3.069; 95%CI = 2.789–3.377); and for ventilatory support (invasive (OR = 10.174; 95%CI = 8.803–11.759) and noninvasive (OR = 1.609; 95%CI = 1.438–1.800)). In conclusion, in Brazil, male patients tend to present the phenotype of higher severity in COVID-19, however, with a small effect on the risk of death.
The Seroprevalence and Hidden Burden of Chikungunya Endemicity and Malaria Mono- and Coinfection in Nigeria
Authors: Asaga Mac Peter , Airiohuodion Philomena E. , Yako Andrew B. , Makpo James K. , Kroeger Axel
Published: July 2022

Background: Mosquito-borne infections are of global health concern because of their rapid spread and upsurge, which creates a risk for coinfections. Chikungunya, an arbovirus disease transmitted by Aedes aegypti or A. albopictus, and malaria, a parasitic disease transmitted by Anopheles gambiae, are prevalent in Nigeria and neighbouring countries, but their burden and possible coinfections are poorly understood. In this study, we investigated the seroprevalence, hidden burden and endemicity of chikungunya and malaria in three regions in Nigeria. Methods: A cross-sectional sero-survey was conducted on 871 participants in three regions of Nigeria. The samples were collected from outpatients employing simple random sampling. All serum sample analyses were performed using CHIKV virus-like particle recomLine Tropical Fever for the presence of arboviral antibody serological marker IgG immunoblot for chikungunya and malaria RDT (Rapid Diagnostic Test) for malaria parasites. Results: The seroprevalences of chikungunya and malaria mono-infection were 64.9% and 27.7%, respectively, while the coinfection seroprevalence was 71.9%. The central (69.5%) and northern (67.0%) regions showed more significant seroprevalences than the southern region (48.0%). The seroprevalence and the hidden burden of chikungunya and malaria infections varied across the three geographical regions. Conclusions: This study highlighted an unexpectedly high seroprevalence and hidden endemicity of chikungunya and a less surprising high malaria endemicity in three regions of Nigeria.
The Moderating Effect of Contact with Children on the Relationship between Adverse Childhood Experiences and Depression in Adulthood among a Chinese Adult Population
Authors: Zhao Yufeng , Wang Dianxi , Du Feilun
Published: July 2022

The effect of adverse childhood experiences (ACEs) on depression in adulthood has been identified in many studies; however, the underlying mechanisms remain unclear. To understand the moderating effect of ACEs on depression, a moderation analysis using the interaction effect model was performed based on data obtained from the China Health and Retirement Longitudinal Study. This study found that people with ACEs had significantly lower depression scores than those without ACEs, particularly in categories such as physical abuse, emotional neglect, sibling death, parental illness/disability, parental depression, hunger, violence, and bullying. In addition, the results indicated that contact with children moderated the relationship between ACEs and depression in adulthood. Increased levels of contact with children reduced the adverse effects of parental drug abuse and the experience of starvation, but not physical abuse. This study highlights the role of family support in eliminating health disparities, which can reduce the effects of ACEs on depression in adulthood.
Spatial Video and EpiExplorer: A Field Strategy to Contextualize Enteric Disease Risk in Slum Environments
Authors: Ajayakumar Jayakrishnan , Curtis Andrew , Rouzier Vanessa , Pape Jean , Bempah Sandra , Alam Meer , Alam Md. , Rashid Mohammed , Ali Afsar , Morris John
Published: July 2022

Disease risk associated with contaminated water, poor sanitation, and hygiene in informal settlement environments is conceptually well understood. From an analytical perspective, collecting data at a suitably fine scale spatial and temporal granularity is challenging. Novel mobile methodologies, such as spatial video (SV), can complement more traditional epidemiological field work to address this gap. However, this work then poses additional challenges in terms of analytical visualizations that can be used to both understand sub-neighborhood patterns of risk, and even provide an early warning system. In this paper, we use bespoke spatial programming to create a framework for flexible, fine-scale exploratory investigations of simultaneously-collected water quality and environmental surveys in three different informal settlements of Port-au-Prince, Haiti. We dynamically mine these spatio-temporal epidemiological and environmental data to provide insights not easily achievable using more traditional spatial software, such as Geographic Information System (GIS). The results include sub-neighborhood maps of localized risk that vary monthly. Most interestingly, some of these epidemiological variations might have previously been erroneously explained because of proximate environmental factors and/or meteorological conditions.
Long-Term Variations in Global Solar Radiation and Its Interaction with Atmospheric Substances at Qomolangma
Authors: Bai Jianhui , Zong Xuemei , Ma Yaoming , Wang Binbin , Zhao Chuanfeng , Yang Yikung , Guang Jie , Cong Zhiyuan , Li Kaili , Song Tao
Published: July 2022

An empirical model to estimate global solar radiation was developed at Qomolangma Station using observed solar radiation and meteorological parameters. The predicted hourly global solar radiation agrees well with observations at the ground in 2008–2011. This model was used to calculate global solar radiation at the ground and its loss in the atmosphere due to absorbing and scattering substances in 2007–2020. A sensitivity analysis shows that the responses of global solar radiation to changes in water vapor and scattering factors (expressed as water-vapor pressure and the attenuation factor, AF, respectively) are nonlinear, and global solar radiation is more sensitive to changes in scattering than to changes in absorption. Further applying this empirical model, the albedos at the top of the atmosphere (TOA) and the surface in 2007–2020 were computed and are in line with satellite-based retrievals. During 2007–2020, the mean estimated annual global solar radiation increased by 0.22% per year, which was associated with a decrease in AF of 1.46% and an increase in water-vapor pressure of 0.37% per year. The annual mean air temperature increased by about 0.16 °C over the 14 years. Annual mean losses of solar radiation caused by absorbing and scattering substances and total loss were 2.55, 0.64, and 3.19 MJ m−2, respectively. The annual average absorbing loss was much larger than the scattering loss; their contributions to the total loss were 77.23% and 22.77%, indicating that absorbing substances play significant roles. The annual absorbing loss increased by 0.42% per year, and scattering and total losses decreased by 2.00% and 0.14% per year, respectively. The estimated and satellite-derived annual albedos increased at the TOA and decreased at the surface. This study shows that solar radiation and its interactions with atmospheric absorbing and scattering substances have played key but different roles in regional climate and climate change at the three poles.
Adolescents’ Characteristics and Peer Relationships in Class: A Population Study
Authors: Cavicchiolo Elisa , Lucidi Fabio , Diotaiuti Pierluigi , Chirico Andrea , Galli Federica , Manganelli Sara , D’Amico Monica , Albarello Flavia , Girelli Laura , Cozzolino Mauro , Sibilio Maurizio , Zelli Arnaldo , Mallia Luca , Germani Sara , Palombi Tommaso , Fegatelli Dario , Liparoti Marianna , Mandolesi Laura , Alivernini Fabio
Published: July 2022

Background: This study aimed to investigate differences in adolescents’ social relationships with classmates of diverse gender, socioeconomic status, immigrant background, and academic achievement. Methods: A population of 10th-grade students (N = 406,783; males = 50.3%; Mage = 15.57 years, SDage = 0.75) completed the Classmates Social Isolation Questionnaire (CSIQ), an instrument specifically designed to measure two distinct but correlated types of peer relationships in class: peer acceptance and peer friendship. To obtain reliable comparisons across diverse adolescent characteristics, the measurement invariance of the CSIQ was established by means of CFAs and then latent mean differences tests were performed. Results: Immigrant background, academic achievement, and socioeconomic status all proved to be important factors influencing relationships with classmates, while being a male or a female was less relevant. Being a first-generation immigrant adolescent appears to be the foremost risk factor for being less accepted by classmates, while having a low academic achievement is the greatest hindrance for having friends in the group of classmates, a finding that diverges from previous studies. Conclusions: This population study suggests that adolescent characteristics (especially immigrant background, socioeconomic status, and academic achievement) seem to affect social relationships with classmates.
Invisible Effect of Virtual Water Transfer on Water Quantity Conflict in Transboundary Rivers—Taking Ili River as a Case
Authors: Xu Xia , Wu Fengping , Yu Qianwen , Chen Xiangnan , Zhao Yue
Published: July 2022

Water stress in countries within a drainage basin exacerbates the water quantity conflict in transboundary rivers. However, few studies considered the invisible effect of virtual water transfer on water quantity conflict by intensifying water stress. Therefore, this study, with Ili River as the case, collects data on Virtual Water Trade (VWT) from 1990 to 2015, uses water stress index (WSI) to assess water stress values under two scenarios (with or without virtual water transfer), and takes Grey Verhulst Model to predict two scenarios water stress values respectively. Next, based on the Levenberg—Marquardt (LM) Algorithm, this study compares the water quantity conflict intensity of the two scenarios, and further explores the invisible effect of virtual water transfer on the conflicts among transboundary rivers. Results show: (1) During the study period (1990–2015), water stress in China and Kazakhstan along the banks of Ili River increased in general. (2) China was basically a net exporter of virtual water during 1990–1995, and Kazakhstan became a net exporter after 1995. (3) During 2020–2025, water conflict value of Ili River without virtual water transfer is 0.458, while the value rises to 0.622 with virtual water transfer, indicating that virtual water transfer between China and Kazakhstan has an invisible enhancement on the water quantity conflict of Ili River. (4) The intensified water quantity conflict is mainly caused by the more and more serious water stress in Kazakhstan. On such basis, it is more urgent for Kazakhstan to restructure its economy and trade.
Did the New French Regulation of Zolpidem Decrease the Problematic Consumption of Zolpidem? A Field Study among Users
Authors: Laforgue Edouard-Jules , Rousselet Morgane , Claudon Antoine , Aquizerate Aurélie , Jolliet Pascale , Istvan Marion , Victorri-Vigneau Caroline
Published: July 2022

Background: The French national drug regulatory authority stated, in 2017, that a secured prescription pad must be used for zolpidem prescriptions. This study aimed to evaluate the evolution of the problematic consumption of zolpidem at the individual level since the new regulation. Methods: Two nationwide populations of at-risk users of zolpidem were recruited: one in general practitioner (GP) offices and one in specialized care centers dedicated to drug dependence (SCDDs). Participants were asked about their zolpidem consumption before and after the regulation change. The primary outcome was the evolution of problematic zolpidem consumption, as defined by at least one of the following criteria: overconsumption, fraudulent ways of obtaining, effects sought other than hypnotic, and modes of administration other than oral. Results: A total of 243 participants were included: 125 from GP offices and 118 from SCDDs. In the GP population, the prevalence of patients who were identified as problematic consumers decreased from 24.8% to 20.8% (p = 0.593), whereas the prevalence decreased from 73.7% to 51.7% in the SCDD population (p < 0.001). The most prevalent criteria for problematic status were overconsumption and fraudulent ways. Conclusions: The new French regulation of zolpidem had different impacts among two different populations of at-risk zolpidem consumers.
Impact of Aircraft Delays on Population Noise Exposure in Airport’s Surroundings
Authors: Zijadić Nermin , Ganić Emir , Bračić Matija , Štimac Igor
Published: July 2022

The motivation behind this research was to analyse the consequences of aircraft operations’ delays on cumulative noise levels produced upon the neighbouring communities and to estimate the relative change in the number of people annoyed by aircraft noise. Many studies showed that residents’ reactions to abrupt changes in noise exposure were more intense compared to the anticipated ones. Aircraft delays may cause such abrupt changes in noise exposure by increasing the traffic in some periods compared to the scheduled traffic. The methodology applied includes noise contour development for two different scenarios for intervals where aircraft delays occur. Only delays connected with the Total Airport Management (TAM) were analysed, since such delays can be influenced by airports. The first scenario considered the influence of aircraft operations on population noise exposure without TAM delays, whereas the second one included all delayed flights (actual traffic). The proposed method was tested through case studies of three southeast European airports. The results showed that the highest potential of decrease in the number of people annoyed by the noise was recorded at Niš Airport (59%), followed by Zadar Airport (49%) and Sarajevo Airport (25%). Similar results were obtained in the context of highly annoyed people.
Increase in Referrals of Children and Adolescents to the Psychiatric Emergency Room Is Evident Only in the Second Year of the COVID-19 Pandemic—Evaluating 9156 Visits from 2010 through 2021 in a Single Psychiatric Emergency Room
Authors: Dror Chen , Hertz-Palmor Nimrod , Yadan-Barzilai Yael , Saker Talia , Kritchmann-Lupo Maya , Bloch Yuval
Published: July 2022

Introduction: The COVID-19 pandemic affected the wellbeing of children and adolescents. The psychiatric emergency room (ER) is the hub of psychiatric emergencies and reflects clinically significant mental problems. Previous studies compared 2019 and 2020 and observed a decline in ER referrals. The current study focused on the continuous trend of referrals from 2010 to the end of 2021. Method: In our observational retrospective study, we procured data from 9156 child and adolescent referrals to our psychiatric ER. The comparison was made based on similar months of each year. Results: There was a significant positive trend in monthly referrals between 2010 and 2021, representing a similar increase in referrals per month in comparison to that month in the preceding year (unstandardized β = 4.21, 95% CI = 3.44 to 4.98, p < 0.0001). Between March 2020 and February 2021 (monthly visits = 72.5 + 16.6 [median = 79.5], annual referrals = 870), we observed no additive effect beyond this general trend after controlling for population growth. Conversely, between March and December 2021 (monthly referrals = 106.1 + 31.8 [median = 105.5], overall referrals = 1061) we observed a significant additive effect beyond the projected incline, as predicted by previous years (β = 21.61, 95% CI = 12.12 to 31.06, p < 0.0001). Conclusions: The first year of the COVID-19 pandemic was no different from the continuous decade long rise of referrals to the children and adolescents’ psychiatric ER. Conversely, the second year showed an additional incline beyond the general trend. The complexity in this rising need demands the awareness of clinicians and policy makers alike.
Individual Workplace Well-Being Captured into a Literature- and Stakeholders-Based Causal Loop Diagram
Authors: Niks Irene M. W. , Veldhuis Guido A. , van Zwieten Marianne H. J. , Sluijs Teun , Wiezer Noortje M. , Wortelboer Heleen M.
Published: July 2022

This study demonstrates an innovative approach to capture the complexity of individual workplace well-being, improving our understanding of multicausal relationships and feedback loops involved. The literature shows that a high number of interacting factors are related to individual workplace well-being. However, many studies focus on subsets of factors, and causal loops are seldomly studied. The aim of the current study was, therefore, to capture individual workplace well-being in a comprehensive conceptual causal loop diagram (CLD). We followed an iterative, qualitative, and transdisciplinary systems-thinking approach including literature search, group model building sessions, retrospective in-depth interviews with employees, and group sessions with human resource professionals, managers, job coaches, and management consultants. The results were discussed with HR and well-being officers of twelve organizations for their critical reflection on the recognizability and potential of the developed CLD. The final result, a conceptual individual workplace well-being CLD, provides a comprehensive overview of multiple, measurable key factors relating to individual workplace well-being and of the way these factors may causally interact over time, either improving or deteriorating workplace well-being. In future studies, the CLD can be translated to a quantitative system dynamics model for simulating workplace well-being scenarios. Ultimately, these simulations could be used to design effective workplace well-being interventions.
The Role of Black Pastors in Disseminating COVID-19 Vaccination Information to Black Communities in South Carolina
Authors: Moore DaKysha , Mansfield Lisa N. , Onsomu Elijah O. , Caviness-Ashe Nicole
Published: July 2022

COVID-19 vaccination rates have increased since distribution began in December 2020. However, in some states, such as South Carolina, getting people to take the vaccine has been challenging; as of spring 2022, slightly less than 60% of the total population is fully vaccinated. Vaccine hesitancy among Black Americans may be explained by several factors, including lack of confidence in the medical establishment and vaccines in particular. Faith-based leaders, such as pastors, can make a difference. This study explores the communication strategies that pastors in predominantly Black churches use to increase COVID-19 vaccination rates among churchgoers and the surrounding community. We conducted semi-structured interviews with 10 pastors in South Carolina. The main themes that emerged are: (1) using various communication channels to ensure access; (2) representing a trusted source of information; (3) offering a role model for vaccination—leading by example; and (4) strengthening the commitment to health. As the need for COVID-19 vaccination continues, including booster vaccines, pastors can provide accurate information and community outreach to promote the health of Black communities.
Effects of COVID-19 on Adolescent Mental Health and Internet Use by Ethnicity and Gender: A Mixed-Method Study
Authors: Kaya M. Siyabend , McCabe Ciara
Published: July 2022

Evidence suggests that mental health problems in young people have been exacerbated by COVID-19, possibly related to a lack of social connection. Young people report using the internet for connecting with their peers and mental health support. However, how they may have used the internet for support during COVID-19 is not clear. We wanted to know how mood and internet use may have changed in young people during COVID-19 and if this was different for those with and without depression symptoms. 108 adolescents were recruited. Participants with high and low levels of depressive symptomatology answered questions about their mood, internet use, loneliness and life satisfaction during July and August 2020. We found that the high depression group reported significantly more loneliness and less life satisfaction than the low depression group. We found that most young people used the internet for mental health information during COVID-19 but that the high depression group used the internet more for mental health information than the low depression group. The high depression group also had a worsening of mood compared to the low depression group during COVID-19. We found that Black, Asian and Minority Ethnic participants reported increased use of the internet compared to White participants during COVID-19 and that the role of the family facilitated coping during COVID-19 for some adolescents, but for others, it made the lockdown more difficult. Finally, we found that adolescents perceived school anxiety as stressful as COVID-19. To conclude this study supports the use of the internet as a way to help young people with mental health challenges. It also suggests that the internet is a way to help young people from ethnic minorities, who otherwise might be hard to reach, during challenging times. This study also shows that supportive family units can be important during times of stress for young people and that school anxiety is a major issue for young people in today’s society even outside of the pandemic.
Changes in Little Cigar and Cigarillo Use during the COVID-19 Pandemic: A Cross-Sectional Analysis of a Nationally Representative Sample of Young Adult Users
Authors: Lee Eugenia , Moore Stephanie Pike , Trapl Erika , Fryer Craig S. , Gunzler Douglas , Sterling Kymberle L.
Published: July 2022

We examined the smoking behaviors of U.S. young adults ages 18–36 regarding little cigars and cigarillos (LCCs) during the COVID-19 pandemic. Survey data were collected from a nationally representative sample of young adults between October and November 2020. Respondents who reported using LCCs with tobacco (CAI) and/or with marijuana (CAB) within the past 6 months prior to the survey (n = 399) were included in the study. Logistic regression analyses assessed the association between their perceived risk of having COVID when smoking LCCs and pandemic-related behavioral changes in CAI and CAB use (e.g., worrying, quit attempts, smoking more, smoking less). Findings showed that users with a higher perceived risk of getting COVID-19 when smoking LCCs were more likely to endorse trying to quit CAI and CAB during the pandemic. Compared to the non-Hispanic White population, the non-Hispanic Black population were less likely to endorse smoking less CAI and trying to quit CAB during the pandemic. Dual users of CAI and CAB and females were more likely to endorse smoking more CAB compared to CAB-only users and males, respectively. Tailored cessation strategies are needed for dual users, non-Hispanic Black young adults, and young women. Raising awareness about the risks of LCC use can be an effective strategy for LCC smoking cessation.
Telomere Length and Hearing Loss: A Two-Sample Mendelian Randomization
Authors: Liu Yun , Liu Shuangyan , Xin Jiarui , Qian Peiyi , Guo Shuli , Xu Xiaojun , Wang Dahui , Yang Lei
Published: July 2022

Background: Observational studies have suggested that there may be an association between telomere length (TL) and hearing loss (HL). However, inferring causality from observational studies is subject to residual confounding effects, reverse causation, and bias. This study adopted a two-sample Mendelian randomization (MR) approach to evaluate the causal relationship between TL and increased risk of HL. Methods: A total of 16 single nucleotide polymorphisms (SNPs) associated with TL were identified from a genome-wide association study (GWAS) meta-analysis of 78,592 European participants and applied to our modeling as instrumental variables. Summary-level data for hearing loss (HL), age-related hearing loss (ARHL), and noise-induced hearing loss (NIHL) were obtained from the recent largest available GWAS and five MR analyses were used to investigate the potential causal association of genetically predicted TL with increased risk for HL, including the inverse-variance-weighted (IVW), weighted median, MR-Egger regression, simple mode, and weighted mode. In addition, sensitivity analysis, pleiotropy, and heterogeneity tests were also used to evaluate the robustness of our findings. Results: There was no causal association between genetically predicted TL and HL or its subtypes (by the IVW method, HL: odds ratio (OR) = 1.216, p = 0.382; ARHL: OR = 0.934, p = 0.928; NIHL: OR = 1.003, p = 0.776). Although heterogenous sites rs2736176, rs3219104, rs8105767, and rs2302588 were excluded for NIHL, the second MR analysis was consistent with the first analysis (OR = 1.003, p = 0.572). Conclusion: There was no clear causal relationship between shorter TLs and increased risk of HL or its subtypes in this dataset.
Association between Urban Built Environments and Moderate-to-Vigorous Physical Activity of Adolescents: A Cross-Lagged Study in Shanghai, China
Authors: Guo Zhengmao , Xu Yatao , Li Shouming , Qi Changzhu
Published: July 2022

The aim of this study was to determine the relationship between the built environment and moderate-to-vigorous physical activity (MVPA) among adolescents aged 14–16 years. This study used a cross-lagged panel analysis to investigate the relationship between the urban built environment and adolescents’ MVPA in Shanghai, China. A total of 517 adolescents (275 boys and 242 girls) aged 14–17 years were recruited in Shanghai, China. Geographic information system technology was used to collect data on the built environment variables of the residential areas assessed. ActiGraphGT3X+ was used to monitor the physical activity of the adolescents at two time points (T1 and T2) spanning 2 years. The correlations between the T1 and T2 built environment variables were significant (r = 0.54–0.65, p < 0.05), and the T2 built environment was significantly better than the T1 built environment. The correlation between the T1 and T2 MVPA was significant (r = 0.28–0.56, p < 0.05), and the T2 weekend MVPA was higher than the T1 weekend MVPA. The T1 built environment could not predict the T2 weekday MVPA (β = 0.17, p > 0.05), but it positively predicted the T2 weekend MVPA (β = 0.24, p < 0.05). In conclusion, the urban built environment significantly affected weekend MVPA among adolescents.
Proposing a Robust Model to Reduce Employees’ Turnover Intentions in an Ethical Leadership Framework: Empirical Evidence from the Healthcare Sector
Authors: Jian Qiangzhen , Wang Xiuting , Al-Smadi Hisham Mohammad , Waheed Aamer , Badulescu Alina , Samad Sarminah
Published: July 2022

Employee turnover is expensive and disruptive for an organization. Studies have already mentioned that the economic cost of turnover is huge, ranging from 90% to 200% of the existing employee’s salary. With an increase in turnover rate, the social fabric of an enterprise may be disrupted. Additionally, organizations with an increasing turnover are expected to lose intangible knowledge and skills, operational effectiveness, customer satisfaction, and product or service quality. In a healthcare context, an increasing turnover rate has more consequences than other sectors because the healthcare sector worldwide is already identified as a sector facing resource scarcity. Exacerbating the situation, current evidence suggests that employee turnover has been increasing globally in the healthcare sector. The literature suggests that an ethical leadership style may reduce employees’ likelihood of quitting an organization. However, such literature is sparse in healthcare, especially from the perspective of a developing economy in the Global South, which is more resource-deficient than the Global North. To fill this knowledge gap, this study investigates the relationship between ethical leadership style and turnover intentions in the healthcare context of the Global South. This study also tests the mediating effect of intrinsic motivation and psychological contract fulfillment in the above-proposed relationship. Furthermore, the conditional indirect effect of resilience is also tested. The data are collected from the hospital employees through a self-administered questionnaire. The hypothesized relationships are tested through structural equation modeling. The empirical evidence indicates that ethical leadership reduces employees’ turnover intentions significantly. The results further confirm the mediating and moderating effects of intrinsic motivation, psychological contract fulfillment, and resilience. These results have different theoretical and practical implications for the healthcare sector. The results especially highlight the role of ethical leaders in a hospital to deal with the challenge of turnover, which has been rising worldwide.
Beyond Screen Time: Exploring the Associations between Types of Smartphone Use Content and Adolescents’ Social Relationships
Authors: Huang Shunsen , Lai Xiaoxiong , Zhao Xinmei , Dai Xinran , Yao Yuanwei , Zhang Cai , Wang Yun
Published: July 2022

The past two decades have witnessed controversy over whether the use of digital technology has damaged or enhanced adolescents’ social relationships, which influences their development. In this study, we addressed this debate by specifying the effect of different types of smartphone use content on social relationships, rather than simply relying on screen time spent on digital media. To avoid selective analysis and report of different variables, we used specification curve analysis (SCA) in a large dataset (N = 46,018) to explore the correlations between 20 types of smartphone use content and adolescents’ social relationships (parent–child, peer, and teacher–student). The types of smartphone use content were measured by the revised version of Mobile Phone Use Pattern Scale, the Parent-Child Relationship Scale, the Peer Relationship Scale, and the Teacher-Student Relationship Scale assessed three different social relationships, respectively. Of the 20 types of smartphone use content, only playing games (negatively explaining 1% of the variation), taking online courses (positively explaining 1.6% of the variation), using search engines (positively explaining 1.2% of the variation), using a dictionary (positively explaining 1.3% of the variation), and obtaining life information (positively explaining 1.5% of the variation) showed a significant effect size. The association between smartphone use and adolescents’ social relationships depends on the various types of content with which adolescents engage during smartphone use. The various effects of different types of smartphone use content deserve the attention of both the public and policy-makers.
A Data Analytics Approach to Assess the Functional and Physical Performance of Female Soccer Players: A Cohort Design
Authors: González-Fernández Francisco Tomás , Castillo-Rodríguez Alfonso , Rodríguez-García Lorena , Clemente Filipe Manuel , Silva Ana Filipa
Published: July 2022

Background and Objectives: The aim of this study was twofold: (i) to observe the individual results of fitness status [countermovement jump (CMJ)], hop test, linear sprinting time, stride frequency, stride distance, force–power–velocity, peak power maximal and maximal speed, and repeated sprint ability (RSA) and functional performance (overhead squat, single-leg squat test, dumbbell hip-hinge, Thomas test, hip extension, and internal and external hip rotators) and (ii) to analyze the relationship between anthropometrical measures and values of fitness status with % of difference in the Thomas test, hip extension, and internal and external hip rotators. Materials and Methods: The study followed a cohort design. Sixteen female soccer players competing in the second division of the Spanish league were monitored during the first days of the pre-season. These players were evaluated three times during the preseason of the cohort period. The dataset showed a negative moderate correlation between time and percentage of difference in hip angle and another positive moderate correlation between maximal sprint and percentage of difference in hip angle (r = −0.54, p = 0.02 and r = 0.53, p = 0.04), respectively. The correlations of stride time and distance with hip extension are interesting, as professional soccer players should have higher levels of hip flexor flexibility during the stride phase, recoil of the instep kick action.
Consumers’ Willingness to Pay for Rice from Remediated Soil: Potential from the Public in Sustainable Soil Pollution Treatment
Authors: Wang H. Holly , Yang Jing , Hao Na
Published: July 2022

Remediation of polluted soil on arable land is mostly funded by governments, with the understanding that the public’s willingness to pay for food produced on remediated soil can help establish a soil remediation model with more stakeholders. In contrast to previous studies that have focused on soil-remediation technologies’ diffusion, this study employs choice experiments to evaluate market preferences for crops grown from lands of varying quality that are reflected in consumers’ willingness to pay (WTP). The results show that consumers are willing to pay a small premium for rice labeled with remediated-soil claims, but the WTP for remediated-soil claim is less than that of an uncontaminated-soil claim. Consumers’ WTP for remediated-soil claim increases by 29.03% when combining with a well-known brand, and it increases by 71.17% when information is provided about the efficacy of cadmium and heavy-metal-pollution remediation; however, combining with the region-of-origin label does not increase WTP. We also find that, in early stages of promotion, online stores may reach target consumers more easily. Based on these results, we propose four implications for policymakers.
The Single-Stranded DNA-Binding Gene Whirly (Why1) with a Strong Pathogen-Induced Promoter from Vitis pseudoreticulata Enhances Resistance to Phytophthora capsici
Authors: Lai Chengchun , Que Qiuxia , Pan Ruo , Wang Qi , Gao Huiying , Guan Xuefang , Che Jianmei , Lai Gongti
Published: July 2022

Vitis vinifera plants are disease-susceptible while Vitis pseudoreticulata plants are disease-resistant; however, the molecular mechanism remains unclear. In this study, the single-stranded DNA- and RNA-binding protein gene Whirly (VvWhy1 and VpWhy1) were cloned from V. vinifera “Cabernet Sauvignon” and V. pseudoreticulata “HD1”. VvWhy1 and VpWhy1 promoter sequences (pVv and pVp) were also isolated; however, the identity of the promoter sequences was far lower than that between the Why1 coding sequences (CDSs). Both Why1 gene sequences had seven exons and six introns, and they had a C-terminal Whirly conserved domain and N-terminal chloroplast transit peptide, which was then verified to be chloroplast localization. Transcriptional expression showed that VpWhy1 was strongly induced by Plasmopara viticola, while VvWhy1 showed a low expression level. Further, the GUS activity indicated pVp had high activity involved in response to Phytophthora capsici infection. In addition, Nicotiana benthamiana transiently expressing pVp::VvWhy1 and pVp::VpWhy1 enhanced the P. capsici resistance. Moreover, Why1, PR1 and PR10 were upregulated in pVp transgenic N. benthamiana leaves. This research presented a novel insight into disease resistance mechanism that pVp promoted the transcription of Why1, which subsequently regulated the expression of PR1 and PR10, further enhancing the resistance to P. capsici.
Integrated Analysis of Microarray, Small RNA, and Degradome Datasets Uncovers the Role of MicroRNAs in Temperature-Sensitive Genic Male Sterility in Wheat
Authors: Liu Yongjie , Li Dan , Zhang Shengquan , Zhang Liping , Gong Jie , Li Yanhong , Chen Jiamin , Zhang Fengting , Liao Xiangzheng , Chen Zhaobo , Wang Yongbo , Pang Binshuang , Ma Jinxiu , Chen Xianchao , Gao Jiangang , Zhao Changping , Gao Shiqing
Published: July 2022

Temperature-sensitive genic male sterile (TGMS) line Beijing Sterility 366 (BS366) has been utilized in hybrid breeding for a long time, but the molecular mechanism underlying male sterility remains unclear. Expression arrays, small RNA, and degradome sequencing were used in this study to explore the potential role of miRNA in the cold-induced male sterility of BS366. Microspore observation showed defective cell plates in dyads and tetrads and shrunken microspores at the vacuolated stage. Differential regulation of Golgi vesicle transport, phragmoplast formation, sporopollenin biosynthesis, pollen exine formation, and lipid metabolism were observed between cold and control conditions. Pollen development was significantly represented in the 352 antagonistic miRNA-target pairs in the integrated analysis of miRNA and mRNA profiles. The specific cleavage of ARF17 and TIR1 by miR160 and miR393 were found in the cold-treated BS366 degradome, respectively. Thus, the cold-mediated miRNAs impaired cell plate formation through repression of Golgi vesicle transport and phragmoplast formation. The repressed expression of ARF17 and TIR1 impaired pollen exine formation. The results of this study will contribute to our understanding of the roles of miRNAs in male sterility in wheat.
Parkinson’s Disease Etiology: Insights and Associations with Phosphate Toxicity
Authors: Brown Ronald B.
Published: July 2022

The present paper investigated the association of Parkinson’s disease etiology with phosphate toxicity, a pathophysiological condition in which dysregulated phosphate metabolism causes excessive inorganic phosphate sequestration in body tissue that damages organ systems. Excessive phosphate is proposed to reduce Complex I function of the mitochondrial electron transport chain in Parkinson’s disease and is linked to opening of the mitochondrial permeability transition pore, resulting in increased reactive oxygen species, inflammation, DNA damage, mitochondrial membrane depolarization, and ATP depletion causing cell death. Parkinson’s disease is associated with α-synuclein and Lewy body dementia, a secondary tauopathy related to hyperphosphorylation of tau protein, and tauopathy is among several pathophysiological pathways shared between Parkinson’s disease and diabetes. Excessive phosphate is also associated with ectopic calcification, bone mineral disorders, and low levels of serum vitamin D in patients with Parkinson’s disease. Sarcopenia and cancer in Parkinson’s disease patients are also associated with phosphate toxicity. Additionally, Parkinson’s disease benefits are related to low dietary phosphate intake. More studies are needed to investigate the potential mediating role of phosphate toxicity in the etiology of Parkinson’s disease.
Membrane Fusion and SNAREs: Interaction with Ras Proteins
Authors: Margiotta Azzurra
Published: July 2022

The superfamily of Ras proteins comprises different molecules belonging to the GTPase family. They normally cycle between an active state bound to GTP which activates effectors while the protein is membrane-associated, and an inactive GDP-bound state. They regulate the intracellular trafficking and other cellular processes. The family of Rab proteins includes several members and they have been found, among other Ras proteins, to be fundamental for important biological processes, such as endocytosis and exocytosis. SNARE proteins control the fusion of vesicles by forming quaternary complexes which are divided into two small groups on the two different compartments. Generally, the association of three SNARE proteins on the donor compartment with the one on the target compartment determines the formation of the SNARE complex, the opening of the fusion pore and the formation of one single bigger vesicle. Interestingly, novel interactions between other molecules involved in intracellular trafficking, endosomal fusion and maturation have recently been found, such as the interaction between invariant chain and the Qb SNARE vti1b, and more functional connections between Rab proteins and SNAREs are supposed to be fundamental for the regulation of membrane fusion.
NO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured Endothelium
Authors: Ghim Mean , Yang Sung-Wook , David Kamilah R. Z. , Eustaquio Joel , Warboys Christina M. , Weinberg Peter D.
Published: July 2022

Haemodynamic wall shear stress varies from site to site within the arterial system and is thought to cause local variation in endothelial permeability to macromolecules. Our aim was to investigate mechanisms underlying the changes in paracellular permeability caused by different patterns of shear stress in long-term culture. We used the swirling well system and a substrate-binding tracer that permits visualisation of transport at the cellular level. Permeability increased in the centre of swirled wells, where flow is highly multidirectional, and decreased towards the edge, where flow is more uniaxial, compared to static controls. Overall, there was a reduction in permeability. There were also decreases in early- and late-stage apoptosis, proliferation and mitosis, and there were significant correlations between the first three and permeability when considering variation from the centre to the edge under flow. However, data from static controls did not fit the same relation, and a cell-by-cell analysis showed that <5% of uptake under shear was associated with each of these events. Nuclear translocation of NF-κB p65 increased and then decreased with the duration of applied shear, as did permeability, but the spatial correlation between them was not significant. Application of an NO synthase inhibitor abolished the overall decrease in permeability caused by chronic shear and the difference in permeability between the centre and the edge of the well. Hence, shear and paracellular permeability appear to be linked by NO synthesis and not by apoptosis, mitosis or inflammation. The effect was mediated by an increase in transport through tricellular junctions.
The mTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data
Authors: Vakrakou Aigli G. , Alexaki Anastasia , Brinia Maria-Evgenia , Anagnostouli Maria , Stefanis Leonidas , Stathopoulos Panos
Published: July 2022

This article recapitulates the evidence on the role of mammalian targets of rapamycin (mTOR) complex pathways in multiple sclerosis (MS). Key biological processes that intersect with mTOR signaling cascades include autophagy, inflammasome activation, innate (e.g., microglial) and adaptive (B and T cell) immune responses, and axonal and neuronal toxicity/degeneration. There is robust evidence that mTOR inhibitors, such as rapamycin, ameliorate the clinical course of the animal model of MS, experimental autoimmune encephalomyelitis (EAE). New, evolving data unravel mechanisms underlying the therapeutic effect on EAE, which include balance among T-effector and T-regulatory cells, and mTOR effects on myeloid cell function, polarization, and antigen presentation, with relevance to MS pathogenesis. Radiologic and preliminary clinical data from a phase 2 randomized, controlled trial of temsirolimus (a rapamycin analogue) in MS show moderate efficacy, with significant adverse effects. Large clinical trials of indirect mTOR inhibitors (metformin) in MS are lacking; however, a smaller prospective, non-randomized study shows some potentially promising radiological results in combination with ex vivo beneficial effects on immune cells that might warrant further investigation. Importantly, the study of mTOR pathway contributions to autoimmune inflammatory demyelination and multiple sclerosis illustrates the difficulties in the clinical application of animal model results. Nevertheless, it is not inconceivable that targeting metabolism in the future with cell-selective mTOR inhibitors (compared to the broad inhibitors tried to date) could be developed to improve efficacy and reduce side effects.
Hepatoprotective Effect of Oyster Peptide on Alcohol-Induced Liver Disease in Mice
Authors: Wang Xueqin , Yu Huahua , Xing Ronge , Li Pengcheng
Published: July 2022

Alcohol-induced liver disease (ALD) has become one of the major global health problems, and the aim of this study was to investigate the characterization of the structure as well as the hepatoprotective effect and mechanism of oyster peptide (OP, MW < 3500 Da) on ALD in a mouse model. The results demonstrate that ethanol administration could increase the activities of aspartate aminotransferase (AST), alanine transaminase (ALT), γ-Glutamyl transferase (GGT), reactive oxygen species (ROS), malondialdehyde (MDA), and triglycerides (TG), as well as increase the interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) levels (p < 0.01), and reduce the activity of superoxide dismutase (SOD) and the concentration of glutathione (GSH). Those changes were significantly reversed by the application of different doses of OP. Furthermore, the mRNA expressions of nuclear factor elythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and quinone oxidoreductase1 (NQO1) were significantly up-regulated in OP groups, and the mRNA expressions of nuclear factor kappa-light chain enhancer of B cells (NF-κB), TNF-α, and IL-6 were markedly reduced in OP groups compared to that of the model group. Thus, OP had a significant protective effect on ALD through the enhancement of the in vivo antioxidant ability and the inhibition of the inflammatory response as possible mechanisms of action, which therefore suggests that OP might be useful as a natural source to protect the liver from alcohol damage.