bluuebunny/crossref_metadata_2025 huggingface dataset:
Political Messianism as the Basis of the Russian Imperial Myth
Authors: Tselykovskiy Aleksey Andreevich
Published: January 2024

The subject of this study is the content, structure, and functions of the imperial political myth. The relevance of the research topic is dictated by the current political situation. In the conditions of growing global political tension and confrontation between Russia and Western countries, accompanied by information and memorial wars, the problem of searching for spiritual and value bases of modern Russian public consciousness arises. Myth, as a social phenomenon, has a powerful meaning-forming potential. Therefore, the practical significance of analyzing the processes of myth-making is to obtain effective tools for managing social processes. The imperial myth is a stable set of political myths rooted in the national culture and largely predetermining the specifics of political traditions. The process of formation of the imperial myth was considered in its historical dynamics at different stages of the Russian state existence. For this purpose, comparative-historical analysis, interdisciplinary analysis, systemic and holistic approach, as well as the principles of the dialectical method were used. The analysis suggests that the imperial myth is based on political messianism. The phenomenon of political messianism is a set of socio-political myths that form an idea of the special position of a nation and assert the existence of its special historical mission, as well as set vectors for the development of political practice. The Messianic imperial myth played a major role in the process of formation and consolidation of the unified Russian state. Later it underwent various transformations. In modern Russian political practice the imperial messianic myth again acquires the status of one of the main elements. Understanding the specifics of modern mythmaking practice with the help of the concept "imperial myth" allows us to take a new look at the political sphere and identify its inherent tendencies.
Restaurācijas gadījums: Veģetatīvās nervu sistēmas modelis Nr. 9
Authors: Skripste Iveta
Published: January 2024

Veģetatīvās nervu sistēmas modelis Nr. 9 ir vēsturisks Rīgas Medicīnas institūta (RMI) mācību uzskates līdzeklis, ko 2008. gadā Rīgas Stradiņa universitātes (RSU) muzejam nodeva RSU Anatomijas un antropoloģijas institūts. Ar uzskaites numuru RSUM 228 tas iekļauts RSU muzeja vēstures kolekcijā “Studiju un pētnieciskās darbības vēsture”. Kopš 2013. gada šis priekšmets ir eksponēts muzeja pastāvīgajā ekspozīcijā augstskolas galvenajā ēkā Rīgā, Dzirciema ielā 16.
Optimizing PV integration: Addressing energy fluctuations through BIPV and rooftop PV synergy
Authors: Saurabh Saket , Kumar Ramesh
Published: January 2024

The widespread availability and affordability of photovoltaic (PV) systems are driving the future of demand-side generation towards end-user-based PV plants. Building-integrated PV systems offer an additional source of electrical energy, but their power output depends on external factors like solar insolation, weather conditions, geographical location, and earth’s rotation, causing non-constant energy generation, even in ideal weather conditions. In grid-connected systems, this variability leads to fluctuations in grid demand. Both BIVP and rooftop PV systems are photovoltaic-based, but their installation differences result in distinct energy generation characteristics. To address this, we propose an innovative approach to optimally integrate BIPV and rooftop PV systems by leveraging their contradictory energy generation nature. By employing mathematical and evolutionary algorithms to design an optimal system and develop a multi-objective optimization model, we address practical design issues. The outcome of these single and multi-objective systems helps minimize fluctuations in grid dependency throughout the year. The proposed system is validated on the IEEE-33 bus radial distribution network using the B&R X20CP1586 PLC, confirming its effectiveness in ensuring a stable and reliable grid performance while mitigating energy fluctuation impacts.
Conforto do recém-nascido em hipotermia terapêutica na perspectiva dos profissionais de enfermagem
Authors: Leite Patrícia Natália Monteiro , Garcia Andrea dos Santos , Machado Daniel Aragão , Reis Adriana Teixeira , Silva Roberto Carlos Lyra da , Teixeira Rosângela Barbosa , Silva Gustavo Dias da , Silva Carlos Roberto Lyra da
Published: January 2024

Objetivo: Identificar nas falas dos profissionais de enfermagem, práticas que possam influenciar no conforto dos recém-nascidos durante a hipotermia terapêutica, identificar possíveis sinais semiológicos que caracterizam o desconforto e descrever os aspectos de conforto. Métodos: Pesquisa descritiva com abordagem quanti-qualitativa, desenvolvida em uma Unidade de Terapia Intensiva Neonatal de um hospital universitário do estado do Rio de Janeiro. A coleta ocorreu entre fevereiro a junho de 2022; participaram do estudo 28 profissionais de enfermagem. A partir dos dados textuais originados pela entrevista semiestruturada, foi realizado o processamento dos dados pelo software Iramuteq 7.2. Resultados: Emergiram cinco categorias, sendo elas: achados semiológicos no recém-nascido, predicações de conforto, práticas de conforto, proteção neurológica e acolhimento familiar. Os elementos da assistência que possam promover o conforto ao recém-nascido foram relacionados aos aspectos ambientais, físico e sociocultural. Conclusão: Foi possível identificar que a proteção neurológica, redução da luminosidade e ruídos, alívio da dor e a presença dos pais, são práticas promotoras de conforto ao recém-nascido em hipotermia terapêutica nas unidades neonatais, este estudo visa contribuir com o conhecimento do conceito de conforto para equipes de saúde que assistem diretamente essa clientela, visto a relevância da humanização do cuidado centrado no cliente-família.
Cyclic Flares of Fever, Rash, and Swelling: A Case Report
Authors: Shah Veranca , Rogers Hala , Lockwood Megan , Larson Allison
Published: January 2024

Familial Mediterranean Fever (FMF) is an inherited condition characterized by recurrent bouts of fever and serosal inflammation that most commonly presents in individuals before 10 years of age. Although onset of the disease can occur at an older age, such a presentation is rare, especially after 40 years. This case report aims to highlight the rare manifestation of this disorder in a 63-year-old patient with recurrent bouts of fever and rash. With limited findings and a cure for this disorder, this case delves into the presentation and treatment regimen that provided symptomatic relief to this patient.
A Young Woman with a Cystic Mass in the External Auditory Canal
Authors: Stammen Marcus , Rama Sonam , Smythe Ciaran , Lyles Elliot , Olsen Stephen
Published: January 2024

Introduction: Adenoid cystic carcinoma (ACC) is a malignancy that primarily affects the salivary glands. Primary cutaneous ACC (PCACC) is a rare variant that arises from ceruminous glands of the ear and other glands of apocrine origin.
Case Presentation: We presented a case of a 26-year-old woman evaluated for a slow-growing mass in her ear for several years that was painful with bloody discharge. Physical exam demonstrated a subcutaneous nodule with overlying telangiectasias protruding from the external auditory canal. Excisional biopsy revealed a dermal proliferation of basaloid cells forming islands in a cribriform architecture.
Discussion: PCACC grossly mimics other cysts and tumors, so diagnosis must be histologically confirmed. Basal cell carcinoma, mucinous carcinoma, and spiradenoma can mimic PCACC on microscopy, making differentiation important. PCACC is not associated with common risk factors for malignancy, thus it is important to include on the differential with any auricular tumor presenting as a pearly nodule with blue and purple hues. Despite treatment with wide local excision, postoperative radiation, and less commonly chemotherapy, recurrence rates are high.
Conclusion: It is important to accurately diagnose PCACC, due to the need for long term follow up, as these tumors commonly recur decades later. This case contributes to the growing literature how PCACC can present and how the treatment will shape the trajectory of the patient’s follow up, as there is currently no consensus on definitive treatment.
Pilomatricoma on the Abdomen with Overlying Striae Distensae: A Unique Presentation
Authors: Sparling Kennedy , Harview Christina
Published: January 2024

Pilomatricomas are benign neoplasms of the hair follicle. Alterations in the skin overlying pilomatricomas are rarely reported, and there are no reports with overlying striae distensae. We present an unusual case of pilomatricoma with overlying striae distensae on the flank of a young man and report its clinical findings. Recognition of this unique presentation of pilomatricomas is important for timely diagnosis and improved patient care, as these lesions have the potential for malignant transformation into pilomatrix carcinoma.
Improvement of the Head and Neck Regions with Continuous Tralokinumab treatment for Up to 4 years in Adults with Moderate-to-Severe Atopic Dermatitis
Authors: Chovatiya Raj , Wollenberg Andreas , Ribero Simone , Saeki Hidehisa , Øland Christian , Steffensen Louise , Tindberg Ann-Marie , Thyssen Jacob , Blauvelt Andrew
Published: January 2024

Introduction: Atopic dermatitis (AD) is a chronic, inflammatory disease that can affect multiple regions of the body, but can be particularly burdensome on exposed areas of skin, such as the head and neck (H&N).Tralokinumab, a high-affinity monoclonal antibody that specifically neutralizes interleukin-13, is approved in multiple countries for adults with moderate-to-severe AD. Phase 3 trials showed tralokinumab provided significant improvements in AD severity and was well-tolerated up to 52 weeks of treatment. The ongoing open-label, 5-year extension trial, ECZTEND (NCT03587805), assesses the safety and efficacy of tralokinumab after the completion of parent trials (PT). Here, tralokinumab efficacy was assessed in the H&N region.

Methods: This post hoc analysis included adult patients with moderate-to-severe AD initially randomized to tralokinumab 300mg Q2W in the phase 3 PTs ECZTRA 1 (NCT03131648) or ECZTRA 2 (NCT03160885). Patients on active tralokinumab treatment were followed for up to 52 weeks in PTs and for up to 152 weeks in ECZTEND as of data cutoff April 30, 2022. Patients re-randomized to placebo at Week (Wk) 16 were not included beyond that timepoint. For this analysis, overall EASI and H&N regional EASI (H&N EASI) were evaluated. H&N EASI (0-7.2) was calculated based on the severity of erythema, induration/papulation, excoriation, lichenification and area of involvement. All data were analyzed and presented as observed.

Results: At baseline, 87.8% (1047/1192) of patients had H&N involvement (H&N EASI>1), and 49.9% (591/1192) of patients exhibited severe AD (IGA 4). Baseline median H&N EASI for the pooled PTs was 3.0 (IQR 1.8; 4.5). In the pooled PTs, 48.2% (542/1125) and 71.2% (558/784) of patients achieved H&N EASI≤1, at Wk16 and Wk52, respectively. After 3 years additional treatment (Wk152 in ECZTEND), the proportion of patients with H&N EASI≤1 was 87.2% (232/266) and the median H&N EASI was 0.2 (IQR 0.0; 0.5). In the subgroup of patients (n=301) with severe AD (IGA 4) and high H&N involvement (H&N EASI≥4), median H&N EASI improved from 5.4 at baseline to 2.4 and 0.8 at Wk16 and Wk52, respectively, and 0.4 at Wk152. Improvements in H&N region were comparable to overall EASI improvement.

Conclusions: Tralokinumab provided sustained improvements in the H&N regions in patients with moderate-to-severe AD for up to 4 years. Sustained improvements were also seen in patients with severe disease and substantial H&N involvement at baseline.
Incremental Risk of Adverse Events with Oral Janus Kinase Inhibitor Use in Atopic Dermatitis and Other Indications: A Systematic Review and Meta-Analysis
Authors: Brandi Henrik , Schneider Shannon , Ryttig Lasse
Published: January 2024

Introduction: The number of treatment opportunities for patients with moderate-severe atopic dermatitis (AD) is increasing, however with varying treatment safety profiles. The safety profile of oral JAKis remains a concern because of their ubiquitous mechanism of action inhibiting many cytokines. Safety warnings for these products have combined data across indications, making it difficult to assess risk for specific populations.

Objective: We aimed to estimate the incremental risk of pre-specified adverse events (AEs) per patient-year (PY) of oral JAKi compared with standard of care (SoC), incl. topical corticosteroids, biologic agents, and other treatments, among those with AD or with other diagnoses.

Methods: A systematic literature review was conducted on 17 preselected AEs based on randomized controlled trials of oral JAKis.

Meta-analyses (MA) estimated the incidence rate difference (IRD) for each AE between oral JAKis and SoC, both in AD and non-AD populations. Number needed to harm (NNH) was calculated as the inverse of the IRD for each AE.  

Results: We identified 82 studies, including 19 in AD population, for use in the MA.

In the AD population, the estimated NNH in PY for acne was 5, indicating 1 additional acne event for every 5 patients treated with oral JAKis vs SoC per year. Moreover, the NNH was 33 for herpes zoster, 62 for anemia, 94 for serious adverse events (SAEs), and 452 for malignancies. In the non-AD population, the NNH was 52 for HZ, 56 for hyperlipidemia, 58 for SAEs, 113 for anemia, 153 for acne, and 254 for malignancies.

Conclusions: The MA identified an increased risk with oral JAKis compared with SoC for multiple AEs, spanning from less to more severe AE, including malignancies in both AD and non-AD populations. As safety risks are observed in both the AD and non-AD populations, the use of oral JAKis should be carefully considered.
Triple-Combination Fixed-Dose Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% for Moderate-to-Severe Acne: Efficacy and Safety Results From a Pooled Phase 3 Analysis
Authors: Stein Gold Linda , Gold Michael , Kircik Leon , Harper Julie , Del Rosso James , Bunick Christopher , Bhatia Neal , Baldwin Hilary , Draelos Zoe , Callender Valerie , Lain Edward
Published: January 2024

Background: A three-pronged approach to acne treatment that combines an antibiotic, antimicrobial agent, and retinoid in a single formulation may be more efficacious than single/double treatments while potentially reducing antibiotic resistance. IDP-126 polymeric mesh gel (clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide [BPO] 3.1%)—the first fixed-dose triple-combination acne topical in development—demonstrated superior efficacy to vehicle and component dyads, with good safety/tolerability in a phase 2 and two phase 3 studies of moderate-to-severe acne. This post hoc analysis further examined efficacy and safety of IDP-126 in data pooled from these phase 3 studies.

Methods: In two identical phase 3 (N=183; N=180; NCT04214639; NCT04214652), double-blind, randomized, 12-week studies, participants aged ≥9 years with moderate-to-severe acne were randomized 2:1 to receive once-daily IDP-126 or vehicle gel. Endpoints included ≥2-grade reduction from baseline in Evaluator’s Global Severity Score and clear/almost clear skin (treatment success) and least-squares mean percent change from baseline in inflammatory/noninflammatory lesion counts. Treatment-emergent adverse events (TEAEs) and cutaneous safety/tolerability were evaluated.

Results: A total of 363 participants were randomized; a majority were female (58.4%) and had moderate acne (91.2%). At week 12, 50.0% of participants achieved treatment success with IDP-126 versus 22.6% with vehicle gel (P<0.001). IDP-126 resulted in over 70% reductions in inflammatory and noninflammatory lesions at week 12, which were significantly greater than vehicle (inflammatory: 77.9% vs 57.9%, respectively; noninflammatory: 73.0% vs 48.2%; P<0.001, both). Most TEAEs were of mild-moderate severity, and <3% of IDP-126-treated participants discontinued study/treatment due to AEs. Transient increases from baseline in investigator-assessed scaling and erythema and participant-assessed itching, burning, and stinging were observed with IDP-126, but resolved back to or near baseline values by week 12.

Conclusions: The innovative fixed-dose triple-combination clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel was efficacious and well tolerated in children, adolescents, and adults with moderate-to-severe acne. Half of participants achieved clear or almost clear skin by 12 weeks, rates not previously seen in clinical studies of other topical acne products.

Funding: Ortho Dermatologics
Clinician Perception of Antibiotics and Antibiotic Resistance in the Context of Managing Acne Vulgaris (AV), and Satisfaction With AV Treatment Outcomes Among Patients Administered Sarecycline in Clinical Practices Across the US: Results from PROSES Study
Authors: Del Rosso James , Stein Gold Linda , Baldwin Hilary , Harper Julie C. , Kircik Leon , Fried Richard G. , Alexis Andrew F. , Rieder Evan A. , Hebert Adelaide , Narayanan Siva , Koscielny Volker , Kasujee Ismail , Graber Emmy
Published: January 2024

Objectives: To evaluate clinician perceptions about antibiotics and antibiotic resistance, and their satisfaction with AV treatment outcomes among AV patients administered sarecycline in community practices across the U.S.
Methods: A single-arm, prospective cohort study (PROSES) was conducted with moderate-to-severe non-nodular AV patients >9 years who were prescribed sarecycline in real-world community practices in the US. At baseline, clinicians were asked about their concerns about antibiotic resistance, disruption of the microbiome with long-term antibiotic use, and the importance of narrow-spectrum antibiotics in supporting antibiotic stewardship; responses were on a 5-point likert scale of 0 (not at all) to 4 (extremely). Clinicians separately reported their level of satisfaction with sarecycline treatment outcomes at week-12.
Results: A total of 253 AV patients (adults 60.08%; pediatric 39.92%) managed by 30 clinicians completed the study. Clinician concerns about antibiotic resistance to manage AV was - extreme:26.67%, moderate:40.00%, somewhat:20.00% and slightly/not-at-all:13.33%. Clinician concerns about disruption of microbiome associated with antibiotic use was - extreme:13.33%, moderate:50.00%, somewhat:20.00% and slightly/not-at-all:16.67%. Clinician reported importance of narrow-spectrum antibiotics in supporting antibiotic stewardship was - extreme:46.67%, moderate:43.33%, somewhat:10.00% and slightly/not-at-all:0%. Majority (88.14%) of clinicians reported very satisfied/satisfied with 12-week treatment outcomes associated with narrow-spectrum antibiotic sarecycline.
Conclusion: Majority of clinicians expressed concerns about antibiotic resistance and associated disruption to microbiome and considered use of narrow-spectrum antibiotic as extremely/moderately important to antibiotic stewardship. Overwhelming majority of clinicians reported satisfaction with sarecycline treatment outcomes after 12 weeks of treatment with sarecycline, a narrow-spectrum, tetracycline-derived antibiotic.
Eradication of lower eyelid retraction and eversion after blepharoplasy. a clinical case
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga branch, Kaluga, Gushchina M.B. , Nadtochiy A.G. ,   Central Research Institute of Dental and Maxillofacial Surgery, Moscow, Tereshchenko A.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga branch, Kaluga, Afanasyeva D.S. ,   Treatment and Diagnostics Centre of Eye Microsurgery Clinic «Okulist», Novosibirsk
Published: January 2024

Most of the literature data on eyelid structures are based on the measurements in cadavers or histological samples. Nonetheless, such data can differ from the living tissues with interstitial fluid and filled vessels. In clinical work, specialists sometimes need to be aware of in vivo parameters of eyelids tissue structures. Purpose. To measure thickness of normal eyelid structures with echographic method and establish normal ranges of these parameters in various age groups in Caucasians. Methods. This prospective observational study comprised 37 patients with a mean age of 46±13.13 years (aged 27–79 years; 28 women). All subjects were divided into 4 groups with an interval of 10 years from 20 to 60 years and a group aged above 60 years. Same operator took measurements of skin, circular eye muscle, conjunctiva, tarsus and their composition of both eyelids with B-scan ultrasonography. Results. We established some age-related trends for all parameters, but two of them change most significantly. The lower eyelid skin thickness in the group of 31–40 years old people (1.2 [1.0; 1.4] mm) significantly differed from the values in the groups of people aged 41–50 (1.65 [1.45; 1.85] mm, p=0.052) and 51–60 years (2.05 [1.73; 2.7] мм, p=0.05). Upper eyelid conjunctiva at the level of tarsal plate upper margin also tends to be thicker in people over 60 years (0.97 [0.8; 1.2] mm) than in younger adults, especially at the age of 21–30 (0.49 [0.44; 0.55], p=0.053) and 41–50 years (0.58 [0.50; 0.65] mm, p=0.053). In addition, it was found that the thicknesses of the upper eyelid structures differ significantly from similar structures of the lower eyelid. The ratio of orbicularis oculi muscle thickness to the thickness of the muscles lifting the upper eyelid is 1:2.1 in average, which ensures their good mobility and protective function. Conclusion. The study provides data about normal eyelid structures thickness in various age groups of Caucasians. The revealed differences between the upper and the lower eyelids are due to their different functionality. Key words: orbicularis oculi muscle; levator; blepharoplasty; aging; blinking; protective function of the eyelids; supportive function of the eyelids
Eradication of lower eyelid retraction and eversion after blepharoplasy. a clinical case
Authors:   IRTC Eye Microsurgery Ekaterinburg Center, Ekaterinburg, Shlyakhtov M. I.
Published: January 2024

Blepharoplasty is a surgical procedure aimed at creation of attractive aesthetic eyelids appearance with mandatory preservation of natural shape and position of the palpeblal fissure. Cicatrical eversion of the lower eyelid which is observed in 1 to 15 % of patients in cases with radical removal of skin, fat and muscles during this operation is the most severe complication after surgery. This paper presents a case of combined surgical correction of bilateral lower eyelids cicatrical eversion grade 3–4 in a 57 years old male suffering from diabetes mellitus after failed circular blepharoplasty. On the right eye, at first free skin grafting with an autograft taken from preauricular face zone was performed to replenish lack of tissues; then pentagonal resection of a lower eyelid portion and punctoplasty were carried out. On the left eye, one-step surgery including eradication of lower eyelid eversion using pentagonal resection method with free skin grafting was performed. The result of surgery was estimated in 3 and 6 months after the operation. Eradication of lower eyelids retraction and eversion, restoration of eyelids closing and cessation of epiphora were marked. The suggested technology allowed good functional and aesthetic result achievement, replenishment of tissues lack, epiphora cessation and elimination of severe complications risk. Key words: revision blepharoplasty; lower eyelid eversion; full-thickness skin graft; pentagonal resection.
Nouveaux taxons pour la Kabylie dans le bassin de l’oued Sahel (Djurdjura / Bibans, Algérie du nord)
Authors: Toumi Rachid , Bouchibane Mebarek , Rebbas Khellaf , Zouggaghe Fatah , Vela Errol
Published: January 2024

Dans l’objectif d’actualiser les connaissances sur le patrimoine naturel, une étude a été réalisée sur la végétation de la vallée d’Oued Sahel (Nord Algérien), un secteur de Kabylie qui est très peu étudié. L’échantillonnage de la flore a révélé l’existence de trois espèces nouvelles pour la flore de la Kabylie, secteur Djurdjura / Bibans (Dipcadi serotinum, Silybum eburneum, Cyperus laevigatus subsp. distachyos) et cinq taxons redécouverts pour la zone d’étude (Silene muscipula subsp. muscipula, Platycapnos tenuiloba, Deverra scoparia subsp. scoparia, Juncus subulatus, Cistanche phelypaea s.l.). L’habitat de ces espèces est menacé par les activités humaines, comme le pâturage et le pompage intensif de l’eau. Ces découvertes enrichissent la flore d’Oued Sahel en particulier et celle de la Kabylie du Djurdjura et des Bibans en général, deux secteurs déjà reconnus comme zones clés de biodiversité (Zones Importantes pour les Plantes).
La sémiotique visuelle entre voie moyenne et nouvelle avant-garde
Authors: Basso Fossali Pierluigi
Published: January 2024

Naguère discipline d’avant-garde, la sémiotique visuelle se trouve aujourd’hui à représenter une position médiane, focalisée sur la textualité et ses traces énonciatives, qui ne semble plus satisfaire pleinement les enjeux herméneutiques du monde contemporaine. Pour réattribuer une position stratégique à la sémiotique visuelle il est moins question d’abandonner des élaborations théoriques du passé que de réintégrer des chemins inachevés ou peu exploiter, comme l’histoire des formes (donc, la dimension diachronique) et la dimension symbolique et institutionnelle du sens. Mais cette récupération de chemins inachevés et prometteurs est-elle suffisante pour assurer un rôle moins périphérique à la sémiotique visuelle ? Faut-il imaginer une nouvelle avant-garde et à partir de quelles bases épistémologiques ? Notre contribution ne veut qu’essayer de thématiser des opportunités pour la sémiotique actuelle en tant que projet collectif.
Animalement vôtre : les limites animales de l’art
Authors: Renoue Marie
Published: January 2024

Notion fondamentale en sémiotique, abstraite donc polyvalente, convoquée par les différences et leurs tensions, par la sémiosis, notion également fondamentale de l’art et des arts qui tentent de la repousser, la « limite » sera ici figurative et conceptuelle, une forme spatio-temporelle, distendue ou concentrée, floue et mobile, tour à tour catégorielle et identitaire, contour et de contraste, énonciative et éthique – et elle nous invitera à interroger l’autonomie de l’art, les statuts actantiels de ses acteurs, la valeur de ses pratiques et des distinctions anthropologiques.
Différer, hyperboliser, interrompre
Authors: Massaert Lucien
Published: January 2024

C’est, nous semble-t-il, le sensible qui caractérise notre rapport aux créations artistiques. Rendre compte de cette dimension sensible de l’œuvre demande l’élaboration d’une « pensée poétique », condition pour chercher à répondre à la question « quand y a-t-il art ? ». À partir des œuvres de Dan Graham, Lawrence Weiner et Peter Downsbrough ‒ représentatives au sein des arts plastiques quant à la déstabilisation poétique de la logique du signifiant ‒ nous voulons montrer que seules l’introduction de la notion d’éthique et la question du statut du sujet permettent de circonscrire l’art et son discours. Ce texte plaide pour aborder l’œuvre dans son processus d’énonciation en saisissant d’un seul tenant sa matérialité, le sujet créateur et le processus symbolique de création du sens et ce, en prenant comme références principales les travaux de Didier Vaudène et du dernier Benveniste.
Le camouflage comme tactique figurative dans la peinture des Anciens Pays-Bas (XVe-XVIIe siècles)
Authors: Lenain Thierry
Published: January 2024

Sur la base d’un anachronisme méthodologique assumé, le concept de camouflage permet de caractériser différents procédés figuratifs en usage dans la peinture des anciens Pays-Bas. Quatre cas de figure sont mis en évidence. Le camouflage peut concerner la structure spatiale d’une scène, des motifs d’importance secondaire, des entités thématiquement liées à l’idée de dissimulation et, paradoxalement, les personnages principaux du mythe chrétien. L’analyse interprétative des images dans lesquelles ces procédés sont mis en œuvre fait intervenir la problématique des modes attentionnels.
The Meaning of Hate, Dehumanization, and Demonization
Authors:   Institute For Kyeongki Cultural Studies, Kim Cheol Ho
Published: January 2024

This article aims to clarify the differences between hate, dehumanization, and demonization. Basically, hate is an emotion. Dehumanization, on the other hand, is an attitude or a way of perceiving another person. Therefore, dehumanization is not a type of hate, nor is it a separate emotion from hate. Dehumanization is an extreme amplification of disgust and is related to disgust in this respect. The same is true for demonization, but it differs from dehumanization in two ways. First, demonization is a form of dehumanization, but it is a more extreme form of dehumanization than animal dehumanization. We can call it demonizing dehumanization. Second, whereas dehumanization excludes the other from the category of morality, demonization places the other on the extreme side of evil within the category of morality. Other than that, the goal is the same: to exterminate the other through violence. Dehumanization of animals and the expression “OO worms” in our society, demonizing dehumanization and demonization in our society may seem similar, but there are differences. In our society, the terms “worms” and “devil” do not envision the other‘s destruction. This level of dehumanization and demonization is referred to in this article as “dehumanizing expressions” and “demonizing expressions”. However, demonization and dehumanization are not new to our society. Comments on articles about violent crime are a classic example. This is why we should care about dehumanization and demonization. Dehumanization and demonization is no one’s problem, it’s everyone’s problem.
Multi-scale Analysis of Interregional Railway Line Names and Station Names’ Territory
Authors:   Institute For Kyeongki Cultural Studies, Kim Jiyoung
Published: January 2024

With the announcement of the Ministry of Land, Infrastructure, and Transport's plan to build the 4th Railway Network Construction Plan, it is time to redefine the nature of existing railway line names and station names and consider how to enact them in the future. The line names and station names of interregional railroads are artificial names with a history of up to 100 years or more, containing the cultural symbols and order of the region, and are closely related to the spatial territory. In particular, this paper focuses on the territories of interregional line names and station names, and analyzes the line names and station names in accordance with the “Guidelines for the Management of Railway Line and Station Names” and multi-scale methods. In order to explore the scope of the “regional” scale in the term “interregional railway”, I analyzed the line name, territory of the line, and actual length, and found that the line name, area, and actual length were inconsistent with each other. A large number of station names, the scale of the station name was revealed by the administrative division system. Other types of station names were analyzed using two strategies: scaling down and scaling up. The scaling down strategy is when the names of public institutions, public facilities, and universities are selected as station names, while the scaling up strategy is when natural, historical, and cultural resources that symbolize the region are selected as station names. On the other hand, the competition for station names has led to the creation of station names that combine place names at multiple scales. There are two types of place names: those that combine two administrative regions and those that combine a place name and an institutional landmark. The historicity of place names, i.e. the time scale of the “past,” allows for the interpretation of station names that could not be categorized by “guideline” standards. In the process of repeatedly expanding and contracting the scale of railway lines, such as extending railway lines and building branches, abandoning lines, and straightening lines, the geographical areas of railway line names and station names shared the same fate. Therefore, it is time to consider a legislation that uses a multi-scale approach to reflect the territories of line names and station names, while also capturing their identity as place names.
Who is My Neighbour: Interfaith Dialogue and Theological Formation (Keynote Address)
Authors: Levine Amy-Jill
Published: January 2024

“Who is my neighbour?” is a good question for both the Bible and today, but it is a complicated one. In this paper, I will focus on unpacking the idea of “love of neighbour,” first in its Levitical context, then in certain New Testament passages, and finally in contrast to its relationship with the concept of “stranger.” The term “neighbour” (רֵעַ) has multiple meanings in a Hebrew Bible context, and similarly, there are distinct meanings of “neighbour” within the New Testament – specifically between the gospels and the Pauline letters. I argue that the common understanding of the “Good Samaritan” passage, that Jesus promotes accepting everyone as neighbour, is incorrect; instead, I suggest that the literature demonstrates how a non-neighbour reveals how real neighbours should behave. The scope of the article is to demonstrate how discussions about “neighbour” and “stranger” can be used to segue into questions to dialogue between Christians and Jews.
Kondisi Daya Tahan Kardiovaskuler Mahasiswa Semester V Prodi PJKR STKIP PGRI Pacitan 2023
Authors: Putro Danang Endarto , Ismoko Anung Probo
Published: January 2024

Daya tahan kardiovaskuler merupakan kondisi kemampuan jantung, paru-paru dan sistem peredaran darah dalam memberikan suplai oksigen ke seluruh tubuh. Kondisi yang maksimal diharapkan dapat menunjang aktivitas sehari-hari terutama para mahasiswa saat menjalankan berbagai kegiatan perkuliahan baik teori maupun praktek. Penelitian bertujuan mengetahui kondisi daya tahan kardiovaskuler mahasiswa semester 5 program studi Pendidikan jasmani kesehatan dan rekreasi STKIP PGRI pacitan. Metode penelitian menggunakan pendekatan survei dengan tes dan pengukuran. Tes kebugaran kardiovaskuler Cooper 2,4 Km digunakan sebagai instrumen penelitian. Sampel menggunakan 20 orang mahasiswa dengan teknik Multiple random sampling. Teknik analisis data menggunakan deskriptif presentase dengan kategorisasi sesuai norma tes cooper untuk menggambarkan daya tahan kardiovaskuler para mahasiswa, Kesimpulan penelitian menunjukkan kondisi daya tahan kardiovaskuler para mahasiswa semester 5 program studi Pendidikan jasmani kesehatan dan rekreasi STKIP PGRI Pacitan dalam kondisi sedang, dengan persentase 45%.
Nucleolar protein TAAP1/C22orf46confers pro-survival signaling in non-small cell lung cancer
Authors: Döring Marietta , Brux Melanie , Paszkowski-Rogacz Maciej , Guillem-Gloria Pedro M , Buchholz Frank , Pisabarro M Teresa , Theis Mirko
Published: January 2024

Tumor cells subvert immune surveillance or lytic stress by harnessing inhibitory signals. Hence, bispecific antibodies have been developed to direct CTLs to the tumor site and foster immune-dependent cytotoxicity. Although applied with success, T cell–based immunotherapies are not universally effective partially because of the expression of pro-survival factors by tumor cells protecting them from apoptosis. Here, we report a CRISPR/Cas9 screen in human non-small cell lung cancer cells designed to identify genes that confer tumors with the ability to evade the cytotoxic effects of CD8+T lymphocytes engaged by bispecific antibodies. We show that the geneC22orf46facilitates pro-survival signals and that tumor cells devoid ofC22orf46expression exhibit increased susceptibility to T cell–induced apoptosis and stress by genotoxic agents. Although annotated as a non-coding gene, we demonstrate thatC22orf46encodes a nucleolar protein, hereafter referred to as “Tumor Apoptosis Associated Protein 1,” up-regulated in lung cancer, which displays remote homologies to the BH domain containing Bcl-2 family of apoptosis regulators. Collectively, the findings establish TAAP1/C22orf46as a pro-survival oncogene with implications to therapy.
The LINC complex ensures accurate centrosome positioning during prophase
Authors: Lima Joana T , Pereira António J , Ferreira Jorge G
Published: January 2024

Accurate centrosome separation and positioning during early mitosis relies on force-generating mechanisms regulated by a combination of extracellular, cytoplasmic, and nuclear cues. The identity of the nuclear cues involved in this process remains largely unknown. Here, we investigate how the prophase nucleus contributes to centrosome positioning during the initial stages of mitosis, using a combination of cell micropatterning, high-resolution live-cell imaging, and quantitative 3D cellular reconstruction. We show that in untransformed RPE-1 cells, centrosome positioning is regulated by a nuclear signal, independently of external cues. This nuclear mechanism relies on the linker of nucleoskeleton and cytoskeleton complex that controls the timely loading of dynein on the nuclear envelope (NE), providing spatial cues for robust centrosome positioning on the shortest nuclear axis, before nuclear envelope permeabilization. Our results demonstrate how nuclear–cytoskeletal coupling maintains a robust centrosome positioning mechanism to ensure efficient mitotic spindle assembly.
Accessory genes define species-specific routes to antibiotic resistance
Authors: Dillon Lucy , Dimonaco Nicholas J , Creevey Christopher J
Published: January 2024

A deeper understanding of the relationship between the antimicrobial resistance (AMR) gene carriage and phenotype is necessary to develop effective response strategies against this global burden. AMR phenotype is often a result of multi-gene interactions; therefore, we need approaches that go beyond current simple AMR gene identification tools. Machine-learning (ML) methods may meet this challenge and allow the development of rapid computational approaches for AMR phenotype classification. To examine this, we applied multiple ML techniques to 16,950 bacterial genomes across 28 genera, with corresponding MICs for 23 antibiotics with the aim of training models to accurately determine the AMR phenotype from sequenced genomes. This resulted in a >1.5-fold increase in AMR phenotype prediction accuracy over AMR gene identification alone. Furthermore, we revealed 528 unique (often species-specific) genomic routes to antibiotic resistance, including genes not previously linked to the AMR phenotype. Our study demonstrates the utility of ML in predicting AMR phenotypes across diverse clinically relevant organisms and antibiotics. This research proposes a rapid computational method to support laboratory-based identification of the AMR phenotype in pathogens.
ZJEDNODUŠENÉ DYNAMICKÉ MODELY V OPTIMALIZACI VYPRUŽENÍ
Authors:   VTS pri Žilinskej univerzite v Žiline, Červenka Zdeněk , Byrtus Miroslav
Published: January 2024

Hlavní motivací pro použití zjednodušených (redukovaných) modelů při návrhu a optimalizaci vypružení kolejového vozidla je možnost rychle v úvodní fázi projektu navrhnout parametry tuhostí a tlumení vzhledem k projektovaným hmotnostem. V dalších fázích projektu umožňují tyto modely provedení nezávislé kontroly a usnadňují interpretaci výsledků získaných z komplexních, multiparametrických MBS výpočtových modelů.
VLIV SEMIAKTIVNÍHO ŘÍZENÍ TLUMIČŮ VRTIVÝCH POHYBŮ NA KRITICKOU RYCHLOST ŽELEZNIČNÍHO VOZIDLA
Authors:   VTS pri Žilinskej univerzite v Žiline, Jeniš Filip , Michálek Tomáš
Published: January 2024

S rozvojem vysokorychlostního železničního systému roste rychlost železničních vozidel, s čímž rostou i požadavky na tato vozidla. Nutnou podmínkou zvyšování rychlosti je přitom zachování stability jízdy vozidla. Při vysoké rychlosti totiž může za určitých podmínek dojít k nestabilnímu chodu, který spočívá v nadměrném rozvinutí samobuzeného příčného kmitání dvojkolí ve volném kanálu koleje s negativními důsledky na silové působení vozidla na kolej, na bezpečnost jízdy i na jízdní komfort.
NUMERICKÁ SIMULACE REÁLNÉ KOLIZE LOKOMOTIVY Ř. 742 S ELEKTRICKOU JEDNOPODLAŽNÍ JEDNOTKOU
Authors:   VTS pri Žilinskej univerzite v Žiline, Ježdík Roman
Published: January 2024

V roce 2008 byla Evropským výborem pro normalizaci schválena norma pod označením EN 15227 [1], která se zabývá pasivní bezpečností kolejových vozidel. Tato norma se stala pro železniční vozidla prostřednictvím TSI [2] závaznou. V oblasti městských kolejových vozidel se na tuto normu odkazuje doporučení Sdružení německých dopravních podniků VDV 152 [3]. Požadavek na plnění této normy je pro výrobce lokomotiv a kolejových vozidel pro přepravu osob v současnosti již zcela běžným. Z tohoto důvodu bylo ve VÚKV a. s. realizováno mnoho numerických simulací za účelem prokázání kolizní odolnosti kolejových vozidel při schvalování. U jednoho z těchto vozidel došlo v nedávné době k reálné nehodě.
JEDNODUCHÁ METODA NÁVRHU PROFILU KOLA PRO DOSAŽENÍ POŽADOVANÝCH HODNOT EKVIVALENTNÍ KUŽELOVITOSTI
Authors:   VTS pri Žilinskej univerzite v Žiline, Kalivoda Jan
Published: January 2024

Ekvivalentní kuželovitost patří mezi nejdůležitější parametry dvojice dvojkolí kolej. Hodnota ekvivalentní kuželovitosti závisí na průběhu změny velikosti valivých poloměrů kol v závislosti na příčné výchylce dvojkolí, tzv. ߜோ funkci, a velikosti amplitudy příčné výchylky dvojkolí pro kterou je ekvivalentní kuželovitost vyhodnocována. Způsoby výpočtu ekvivalentní kuželovitosti dvojice dvojkolí-kolej jsou stanoveny v ČSN EN 15302 [1]. Hodnota ekvivalentní kuželovitosti významným způsobem ovlivňuje jízdní dynamiku a stabilitu vozidla. Při posuzování stability vozidla dle ČSN EN 13363 [2] je proto předepsána minimální hodnota ekvivalentní kuželovitosti v traťových úsecích, kde je stabilita vozidla vyhodnocována.
DYNAMICKÁ INTERAKCE JEDOUCÍHO VOZIDLA S VÝHYBKOU
Authors:   VTS pri Žilinskej univerzite v Žiline, Kohout Martin , Vágner Martin , Hába Aleš
Published: January 2024

Železniční výhybky jsou z pohledu celkových nákladů na údržbu ve srovnání s běžnou kolejí problematickým prvkem infrastruktury. Silové zatěžování neodpružených částí vozidel a poškozování srdcovky je dáno dynamickou interakcí jedoucího vozidla a srdcovky, které se během provozu může výrazně odlišovat od optimalizovaného stavu interakce teoretického dvojkolí a výhybky. Článek se proto zabývá analýzou výsledků měření zrychlení na vozidle, které dává komplexní obraz o dynamickém stavu výhybky a podloží a umožnuje relativní srovnání stavu výhybek stejné konstrukce.
PŘÍNOSY VYUŽITÍ DVOUSTUPŇOVÝCH ŘADITELNÝCH PŘEVODOVEK U LEHKÝCH KOLEJOVÝCH VOZIDEL S ELEKTRICKÝM PŘENOSEM VÝKONU
Authors:   VTS pri Žilinskej univerzite v Žiline, Kolář Josef
Published: January 2024

Na konferencích PRORAIL 2015 a PRORAIL 2019 byly prezentovány konstrukční studie kolejového částečně nízkopodlažního autobusu s hybridním pohonem [1] a lehkého kolejového elektrobusu [2], jak jsme je řešili se studenty magisterského studijního oboru Dopravní technika, zaměření Kolejová vozidla v rámci diplomových prací na Ústavu automobilů, spalovacích motorů a kolejových vozidel, FS ČVUT v Praze. Z pevnostních analýz konstrukcí skříní těchto lehkých KV, dále jen LKV, vyplynulo, že při splnění požadavků kladených na pevnost a crashovou odolnost skříně vozidla, tj. požadavku EN 12 663 (kategorie P2) a EN 15 227 (kategorie CI), nelze částečně nízkopodlažní dvounápravové kolejové autobusy či elektrobusy k provozu na regionálních drahách, definovaných dle zákona č. 266/1994 Sb., použít. Pokud nedojde na regionálních tratích na základě zavedení ETCS a smluvně, definovaného provozního řádu osobní a nákladní železniční dopravy1) ke snížení požadavků kladených na LKV v EN 12 663 (kategorii P3) a v EN 15 227 (kategorii CII), potom lze dosluhující dvou a třívozové soupravy RegioNova nahradit pouze hmotnějšími čtyřnápravovými vozidly.
MODERNÍ VZDĚLÁVÁNÍ PRO OBOR KOLEJOVÝCH VOZIDEL
Authors:   VTS pri Žilinskej univerzite v Žiline, Kopal Tomáš
Published: January 2024

Blížící se výročí 200 let od uvedení do provozu první železnice na Evropském kontinentě z Českých Budějovic do Lince v roce 1825 je jubileem nejen stavby železnic, ale i stavby kolejových vozidel. Ta se v průběhu dvou století zásadním způsobem změnila. Trend růstu parametrů i funkčnosti kolejových vozidel v posledních létech výrazně zvýšil svou dynamiku. Důvod je prostý: po létech stagnace a útlumu nastává období velmi intenzivního rozvoje kolejové dopravy. Nízká energetická náročnost kolejové dopravy, daná nízkým valivým odporem ocelových kol po ocelových kolejnicích a nízkým aerodynamickým odporem dlouhých štíhlých vozidel jedoucích v zákrytu (tvořících vlak), je i po uplynutí dvou set let její základní a vysoce ceněnou vlastností. Koncem předminulého století přibyla k výhodám kolejové dopravy další přednost v podobě schopnosti využit elektrickou vozbu. Již 140 let je součástí železnice i liniové elektrické napájení, které umožňuje bezemisní provoz i bez použití zásobníků energie, které nepříjemně limitují výkonnost i vytrvalost (dojezd). Avšak i na železnici nacházejí vozidla se zásobníky energie uplatnění, a to na méně zatížených železničních tratích bez liniové elektrizace.
FREIGHT RAIL TRANSPORT IN JAPAN – NOT LESS EXCITING THAN PASSENGER ONES
Authors:   VTS pri Žilinskej univerzite v Žiline, Kostrzewski Mariusz
Published: January 2024

Japanese National Railways (JNR) has been privatized in 1987. As Kurosaki [45] stated, during the era of JNR, it accumulated heavy debts, especially in the freight operating area as railways in Japan are passenger-dominated. The conglomerate of Japanese domestic railway operators consists of 6 passenger companies and the seventh one is dedicated to freight operations and transport. Passenger rail transport companies are divided regionally and certainly operate passengers’ trains only. These companies are Hokkaido Railway Company (JR Hokkaido), East Japan Railway Company (JR East), West Japan Railway Company (JR West), Central Japan Railway Company (JR Tokai), Shikoku Railway Company (JR Shikoku), Kyushu Railway Company (JR Kyushu) and additionally Shinkansen Holding Corporation for high-speed rail transport [40]. By the way, it also includes the Railway Communication Company, Rail Information Systems Company, Railway Technical Research Institute, and Japanese National Railways Settlement Corporation [41]. Each of these transportation companies has in disposal their infrastructure and facilities in contrast to Japan Freight Railway Company (JR Freight), the company which operates freight transport. According to [45], JR Freight forms a vertically separated structure, while all the JR passenger companies comprise a vertically integrated structure. JR Freights consists of 6 branches: Kyushu, Kansai, Tokai, Kanto, Tohoku, Hokkaido [40]. JR Freights rents infrastructure from other companies [45], which makes freight transport dependent on time windows between passengers’ transport (more information related to that topic is mentioned hereafter). It does not have own its tracks; however, it has in disposal its own stations, yards, and facilities for freight trains. JR Freights, as many other companies in Japan (e.g. Shizutetsu, Suzuyo – sample companies are mentioned after discussions on the topic during grant in Japan with Prof. Koichi Shintani – private correspondence) is carrying about several different kinds of business, i.e. freight services, warehousing, car park operation, advertising, indemnity and other non-life insurance agency services, vehicle services, general civil engineering and construction design, project execution and management, incidental and related business operations