bluuebunny/crossref_metadata_2025 huggingface dataset:
Top-down ion mobility/mass spectrometry reveals enzyme specificity: Separation and sequencing of isomeric proteoforms
Authors: Berthias Francis , Bilgin Nurgül , Mecinovic Jasmin , Jensen Ole
Published: July 2023

Enzymatic catalysis is one of the fundamental processes that drives the
dynamic landscape of post-translational modifications (PTMs), expanding
the structural and functional diversity of proteins. Here, we assessed
enzyme specificity using a top-down ion mobility spectrometry (IMS) and
tandem mass spectrometry (MS/MS) workflow. We successfully applied
trapped IMS (TIMS) to investigate site-specific N-ε-acetylation of
lysine residues of full-length histone H4 catalyzed by histone lysine
acetyltransferase KAT8. We demonstrate that KAT8 exhibits a preference
for N-ε-actylation of residue K16, while also installing N-ε-acetyl
groups on residues K5 and K8 as the first degree of acetylation.
Achieving TIMS resolving power values of up to 300, we fully separated
mono-acetylated regioisomers (H4K5ac, H4K8ac, and H4K16ac). Each of
these regioisomers produce unique MS/MS fragment ions, enabling
estimation of their individual mobility distributions and the exact
localization of the N-ε-acetylation sites. This study highlights the
potential of top-down TIMS-MS/MS for conducting enzymatic assays at the
intact protein level and, more generally, for separation and
identification of isomeric proteoforms and precise PTM localization.
Asymmetric reactions of stock prices and industrial output to exchange rate shocks: Multiple threshold nonlinear autoregressive distributed lag framework
Authors: Odionye Joseph , Chukwu Jude
Published: July 2023

Motivated by swings in the exchange rate of many developing economies which
exert influence on firms? input costs, output, stock prices, and profits,
the study investigated the asymmetric reactions of stock prices and
industrial output to various shocks in the exchange rate in Nigeria using a
multiple threshold nonlinear autoregressive distributed lag model and high
frequency series from January 1999 to December 2021. Empirical results
suggest that stock prices and industrial output react asymmetrically in the
opposite direction to exchange rate depreciation. It further indicates that
the reactions of both stock prices and industrial output to exchange rate
changes are sensitive to the size of shocks. Exchange rate shocks above the
25th percentile significantly and inversely affect both stock prices and
industrial output, and the effects of exchange rate shocks on stock prices
and industrial output become pernicious if above the 75th percentile. The
main economic implication of the empirical finding is that in the upper
quantile, both exchange rate depreciation and appreciation hurt industrial
output, and hence, stock values. Thus, the multiple threshold nonlinear
autoregressive distributed lag results suggest that the reactions of both
stock prices and industrial output to exchange rate changes are highly
sensitive to the extent of the shocks.
Application of liquid chromatography in defining the interaction of newly synthesized chalcones and related compounds with human serum albumin
Authors: Turkovic Nemanja , Andjelkovic Nastasija , Obradovic Darija , Vujic Zorica , Ivkovic Branka
Published: July 2023

Defining the interaction of newly synthesized compounds with plasma proteins is an important step in the drug development process. Chromatographic techniques can be successfully used in predicting the biopharmaceutical and pharmacokinetic properties of newly synthesized compounds. The aim of this study is to investigate and isolate the most important molecular properties that affect the interaction of 20 newly synthesized chalcones and commercial compounds (lopinavir, ritonavir, darunavir and ivermectin) with human serum albumin (HSA). The retention behaviour of the selected compounds was tested on a CHIRALPAK?HSA column. A mixture of phosphate buffer (pH 7.0) and isopropanol (80:20 volume ratio) was used as the mobile phase, and the support vector method was used to form the quantitative structure retention relationship (QSRR) model. Based on the obtained values of retention parameters, it was observed that halogenated derivatives show the strongest, and methylated chalcone derivatives the weakest interaction with HSA. By correlating the retention and physicochemical properties of the tested compounds, it was shown that the structural (SDSCH) and electronic properties (MAXQ, EEM_F1) groups have the greatest influence on the retention behaviour and the interaction of the tested compounds with HSA. The obtained QSRR model can be applied in the prediction of the retention characteristics of new, structurally related chalcone derivatives on HSA stationary phase.
The (Exit) Price of a Horse: Finding the Fair Value of an Unusual Nonfinancial Asset
Authors: Altiero Elizabeth C. , Libby Theresa , Olczak Wioleta
Published: July 2023

Students are placed in the role of a new employee in the mergers and acquisitions division of a regional accounting firm performing due diligence on a potential acquisition target for their client. Their task is to determine the fair value of a group of unusual nonfinancial assets, the horses owned by the target company, an equine training business. Students evaluate the horse’s highest and best use, identify market participant assumptions, create valuation models, determine the exit price, and perform a sensitivity analysis. Appendix A describes the equine industry and provides a source for many of the necessary valuation assumptions. This case study is complementary to cases where students calculate fair values in more traditional settings and is designed to push them outside their comfort zone while emphasizing that the same familiar concepts apply. The case is recommended for use in advanced financial accounting courses at the undergraduate or master’s levels.

JEL Classifications: M41.
Nonprofessional Investor Judgments: Linking Dependent Measures to Constructs
Authors: Asay H. Scott , Hales Jeffrey , Hinds Cory , Rupar Kathy
Published: July 2023

There is limited evidence on the construct validity of the dependent measures commonly used in the literature on nonprofessional investor judgments. In this paper, we first survey the literature to understand the types of dependent measures typically used by researchers. We then conduct factor analyses to uncover linkages between dependent measures and the constructs underlying these nonprofessional investor judgments. Our results suggest that, while the wide variety of dependent measures can appear on their face to represent many nuanced economic constructs, these measures capture three distinct factors. These factors relate to nonprofessional investors’ (1) expectations regarding future firm performance and value, (2) holistic perceptions of the firm, and (3) evaluations of the risk associated with investing in the firm. Next, we provide recommendations for selecting, analyzing, and reporting dependent measures in future research. Finally, we provide directions for future research to further our understanding of the judgments made by investors.
Glycemic Measures in Childhood as Predictors of Future Diabetes-Related Microvascular Complications in an Indigenous American Population
Authors: Vazquez Laura , Vazquez Arreola Elsa , Hanson Robert L. , Sinha Madhumita
Published: July 2023

OBJECTIVE

To examine the role of glycemic measures performed during childhood in predicting future diabetes-related nephropathy and retinopathy in a high-risk indigenous American cohort.

RESEARCH DESIGN AND METHODS

We studied associations between glycated hemoglobin (HbA1c) and 2-h plasma glucose (PG), measured during childhood (age 5 to <20 years) in a longitudinal observational study of diabetes and its complications (1965–2007), and future albuminuria (albumin creatinine ratio [ACR] ≥30 mg/g), severe albuminuria (ACR ≥300 mg/g), and retinopathy (at least one microaneurysm or hemorrhage or proliferative retinopathy on direct ophthalmoscopy). Areas under the receiver operating characteristic curve (AUCs) for childhood glycemic measures when predicting nephropathy and retinopathy were compared.

RESULTS

Higher baseline levels of HbA1c and 2-h PG significantly increased the risk of future severe albuminuria (HbA1c: hazard ratio [HR] 1.45 per %; 95% CI 1.02–2.05 and 2-h PG: HR 1.21 per mmol/L; 95% CI 1.16–1.27). When categorized by baseline HbA1c, children with prediabetes had a higher incidence of albuminuria (29.7 cases per 1,000 person-years [PY]), severe albuminuria (3.8 cases per 1,000 PY), and retinopathy (7.1 cases per 1,000 PY) than children with normal HbA1c levels (23.8, 2.4, and 1.7 cases per 1,000 PY, respectively); children with diabetes at baseline had the highest incidence of the three complications. No significant differences were observed between AUCs for models with HbA1c, 2-h PG, and fasting PG when predicting albuminuria, severe albuminuria, or retinopathy.

CONCLUSIONS

In this study, higher glycemia levels ascertained by HbA1c and 2-h PG during childhood were associated with future microvascular complications; this demonstrates the potential utility of screening tests performed in high-risk children in predicting long-term health outcomes.
Redes sociais e representação política
Authors: Atieh Sérgio
Published: July 2023

O uso das redes sociais e diferentes aplicativos dos smartphones possibilitam acesso aos desejos e comportamentos de seus usuários. Como nunca temos nossos dados compartilhados tornando possível que nossos passos sejam previstos. Tamanhas transformações alteram o modo de se enxergar a política acentuando a crise de representatividade. Deve-se demonstrar neste artigo como muitas das democracias ocidentais tradicionais que pareciam consolidadas, enfrentam disputas entre quem defende os direitos mais fundamentais e aqueles que pensam que são subterfúgios para garantir regalias de uma casta institucionalizada.
LITERASI DIGITAL SEBAGAI PENGUATAN KOMPETENSI PROFESIONAL GURU DI ABAD-21
Authors:   Universitas Negeri Semarang, Jaenudin Ahmad , Kusumantoro Kusumantoro , Melati Inaya Sari
Published: July 2023

Perkembangan ilmu pengetahuan dan teknologi yang sangat cepat memberikan perubahan tatanan dalam Pendidikan. Arah pendidikan abad-21 mengalami perubahan yang signifikan terutama pada proses pembelajaran. Penerapan teknologi digital pada proses pembelajaran membuat pendidik diharuskan untuk menyesuaikan dengan cepat. Pengenalan metode pembelajaran dengan pendekatan blended learning adalah sebagai respon perkembangan teknologi dalam bidang pendidikan dan pengajaran. Pola interaksi tatap muka disandingkan dengan pola interaksi daring atau Pendidikan jarak jauh. Kurangnya kesiapan pada pendidik dan peserta didik dalam menghadapi perubahan yang cepat menimbulkan berbagai masalah dalam proses pembelajaran. Lemahnya pemahaman pada literasi digital membuat pendidik kesulitan dalam memilih media yang efektif digunakan sehingga proses pembelajaran tidak berjalan efektif. Kegiatan pengabdian kepada masyarakat pada MGMP Ekonomi SMA Jawa Tengah diharapkan dapat menjadi solusi dari permasalahan tersebut. Kegiatan pengabdian kepada masyarakat pada MGMP Ekonomi SMA Jawa Tengah dimaksudkan untuk memberikan penguatan kepada guru agar mampu mengembangkan kemampuan berpikir kritis dan kreatif guna mendorong optimalisasi sumber daya dan pemanfaatan tekonologi digital sebgaia bentuk meningkatkan kompetensi professional guru dalam pembelajaran. Metode yang dilaksanakan pada pengabdian ini dengan mengungkap permasalahan dari mitra. Kegiatan pengabdian ini dilakukan dengan pendampingan berkelanjutan baik dengan metode ceramah tanya jawab, diskusi, simulasi serta pendampingan sehingga menemukan solusi yang tepat. Luaran pengabdian ini adalah publikasi artikel di jurnal nasional terakreditasi dan publikasi pada media massa/elektronik. Kata Kunci : Literasi Digital, MGMP Ekonomi, Jawa Tengah
Systolic Indices of Cardiac Contractility: Modeling and Analysis using Pressure-Volume Loop
Authors: Konecny Filip
Published: July 2023

Modeling cardiac contractility in pre-clinical catheterization laboratory settings remains an important task to collect results under controlled hemodynamic conditions, while providing an assessment of systolic and diastolic indices. Diligent hemodynamic monitoring with acute-based pressure-volume modeling uncovers early indicators of heart failure (HF). In this article, basic procedural assessments are outlined, while deeper dive into systolic index of contractility, the end systolic elastance is provided with references to older, while comparing it to novel approaches. Transient preload reduction using inferior vena cava occlusion (IVCO) is the current standardized maneuver used in hemodynamic protocols to provide an assessment of contractile responsiveness. In this article an example of standard measures from a single catheterization lab were depicted using tables and figures, giving background to transient preload reduction to assess the values of systolic cardiac contractility. Additionally, novel twists on other possible index(ices) coming from capturing ES point may well present future opportunities to collect systolic cardiac contractility. In this instance, both single beat systolic PPESPVR and IVCO using ES points present unique opportunities in this niche area of research. Final two sections of this article are dedicated to procedural steps and how to standardize execution of IVCO. Final section is reserved for analytical steps of how to visually compare systolic indices post-IVCO in case of linear and quadratic relationship.
Matriks Toeplitz dan Determinannya Menggunakan Metode Salihu
Authors: Jannah Miftahul , Rizal Yusmet
Published: July 2023

The matrix is a rectangular array of numbers. In this range the numbers are called the entries of the matrix. In matrix calculations generally focus on square-shaped matrices. There is a matrix called the Toeplitz matrix. The Toeplitz matrix has the same operations and calculations as a square matrix in general, one method for calculating the determinant is the Sarrus method. There is an alternative method to solve the determinant of the matrix, namely the Salihu determinant. The purpose of this research is to know the determinant properties related to the Toeplitz matrix and to know the determinant of the n×n Toeplitz matrix with n≥3 using the Salihu method. The result of this study is that the completion of the Toeplitz matrix determinant calculation will produce the same value as the determinant calculation using the cofactor expansion method.
Optimasi Penjadwalan Perawat IGD RSUD Arosuka dengan Metode 0-1 Fuzzy Goal Programming
Authors: Ramadhani Intan Ayu , Rizal Yusmet
Published: July 2023

Nurse scheduling problem is an important aspect in maintaining the quality of hospital services. The fact that the number of patients is greater than the limited number of nurses and there are rules from the hospital that must be complied with makes the nurse scheduling problem more complex. The purpose of this study was to the shape of the model and the results of optimizing the scheduling of emergency room nurses at Arosuka Hospital using the method 0-1 Fuzzy Goal Programming. Model 0-1 Fuzzy Goal Programming is the result of the application of set theory Fuzzy on Goal Programming that uses a decision variable of 0 or 1. By completing the scheduling model with help  LINGO 20.0 software, the results show that with the methodl 0-1 Fuzzy Goal Programming has fulfilled all existing constraints, and can maximize all objectives. In the manual schedule there are sixty one activities which not corresponding with the policy, while with the 0-1 Fuzzy Goal Programming model it has been minimized so that there are only thirty three activities which not corresponding with the policy.
Penerapan Algoritma Titik Interior dalam Optimasi Keuntungan pada Toko Churro.io
Authors: Kemala Alivia Tasya , Winanda Rara Sandhy
Published: July 2023

Linear Programming is a part of optimization. One of the methods that can be used to solve linear programming problems is the interior point algorithm method. This research is an applied research was aimed to apply the interior point algorithm to solved production optimization problems at Churro.io. The data collection method used in this research was an interview by researcher with Churro.io’s owner. Based on the results of the research using the calculation of the interior point algorithm, a maximum profit of Rp 1.216.400 was obtained by producing 60 units of dark chocolate royal churro, 37 units of white chocolate royal churro, 33 units of matcha royal churro, 21 units of tiramisu royal churro, 21 units of salted caramel royal churro, and 14 units of cheese royal churro. The profit was obtained by Churro.io’s calculation of Rp 890.500, so there is a difference between the calculation of the interior point algorithm and the calculation at the Churro.io of Rp 325.900.
Justice Collaborator’s Position and Function on Witness Protection’s Rights as a Suspect from the Perspective of Criminal Law in Indonesia
Authors: Sholecha Ema Mar’ati , Saiful Ahmat , Yunika Sheilla , Hariyanto Hariyanto , Unsil Norhaiden
Published: July 2023

To handle a specific criminal act, a justice collaborator is greatly required. The concept and term of justice collaborator is something new in Indonesia. This method is practically used to eradicate an organized crime. Both conceptual and statutory approaches were used in this research. Juridical-normative techniques were implemented to descriptively explain the existing problems. This research aimed to deeply and conceptually examine justice collaborator’s position and function in the perspective of Human Rights to protect and provide special treatments to the main actors in cooperating with law enforcement officials (justice collaborators) against an organized crime. The position of justice collaborator either as a witness or suspect to provide information in court and then used as a judge's consideration is to mitigate the sentence to be imposed. This collaboration can provide various benefits, so that law enforcement officials can fight against serious criminal acts. Thus, a justice collaborator has a specific rule (lex specialis derogerat lex generalis) to guide law enforcers, such as police officers, prosecutors, and judges to uncover a specific crime committed by a syndicate deliberately violating laws in very systematic and organized ways.
HALAL ECONOMIC: CHALLENGES AND EMERGING OPPORTUNITIES IN MALAYSIA
Authors:   Faculty of Management and Muamalah, Kolej Universiti Islam Antarabangsa Selangor, Malaysia, Mohd Fauzi Nadzirah , Hashim Nur Iman ,   School of Hospitality and Tourism, SEGi University, Malaysia, Ab Rahman Mohd Fadhli ,   Faculty of Management and Muamalah, Kolej Universiti Islam Antarabangsa Selangor, Malaysia, Wan Hassin Wan Suraya ,   Faculty of Management and Muamalah, Kolej Universiti Islam Antarabangsa Selangor, Malaysia, Shah Shahar Wan Shahzlinda ,   Faculty of Management and Muamalah, Kolej Universiti Islam Antarabangsa Selangor, Malaysia
Published: July 2023

The purpose of the paper is to investigate the challenges and opportunities for halal industries in Malaysia. Since the market for certified Halal products is developing robustly, both domestically and internationally and Malaysia has become the leader and centre of reference for the world. This research builds on existing research published in the Munich Personal RePEc Archive on challenges and opportunities in halal industry. In addition to an extensive literature review, four segment of halal categories were discussed in order to discover the challenges and opportunities with regards to halal industry in Malaysia. The results show that the future market demands and the competitive opportunities related to halal industry are the main motivators for Malaysia to undertaken the significant initiatives across regulation, trade and industry support to strengthen the status as a Halal hub in the trade-driven of Islamic economy. The early adopters for each of halal segments face several challenges such as ambiguous halal guidelines, lack of international halal certification, lack of collaboration among governing agencies (i.e. Jabatan Kemajuan Islam Malaysia (JAKIM) and Halal Industry Development Corporation), a lack of cost-effective standards and a general misunderstanding of halal practices. The findings of the present study may help government policy makers recognise the issues that should be addressed in motivating industries players to adopt halal practices. This study contributes to the advancement of knowledge on the challenges and opportunities of adopting halal certificate in Malaysia. Keywords: Challenges, Halal industry, Islamic economic,Opportunities
Juego de espejos en la construcción del yo lírico lopesco. El caso del soneto “XVIII” de las Rimas sacras (1614)
Authors: Galán García María
Published: July 2023

La obra de Lope de Vega se caracteriza por el recurso a la simulación autobiográfica, con un juego permanente en el que realidad y ficción se entrecruzan para transmitir al lector la sensación de que está ante un relato verídico. Partiendo de esta premisa, el propósito de este trabajo es desentrañar la configuración del yo lírico lopesco, tomando como referencia el poemario sacro del Fénix, Rimas sacras (1614) y, sobre todo, el soneto “XVIII. Este texto, del que se exploran las fuentes e influencias, sirve como ejemplo característico de la construcción de un yo que, sin dejar de ser ficticio, juega a ser reflejo del Lope real.
Ivar Ivask y la poesía de Jorge Guillén: entre Estados Unidos y España
Authors: Garbisu Buesa Margarita
Published: July 2023

El presente trabajo se centra en la labor como mediador cultural del poeta estonio Ivar Ivask, exiliado en Estados Unidos desde 1950. En vinculación con la literatura española, fue uno de los más importantes divulgadores de la obra de Jorge Guillén tanto en su país de origen como en el de acogida. En 1968, por el 75 cumpleaños del poeta, organizó dos importantes actos conmemorativos en torno a su figura en la Universidad de Oklahoma, que serán fundamentales en el estudio crítico posterior de la poesía de Guillén. Con él mantuvo, además, un estrecho vínculo, del que queda constancia en su correspondencia, una de las fuentes fundamentales en el desarrollo de esta investigación.
«Deseo de ser punk» de Belén Gopegui: una lección de inconformismo narrada al ritmo del rock
Authors: Szymoniak Ewelina
Published: July 2023

El objeto de análisis en el artículo es Deseo de ser punk, novela publicada por Belén Gopegui en 2009. La clasificamos genéricamente como una novela de formación y situamos su trama en el contexto de la experiencia generacional del capitalismo. En el artículo nos proponemos averiguar el papel que desempeña la música rock en la formación de la conciencia de la protagonista del libro. Comparamos Deseo de ser punk de Gopegui con el discurso sociológico sobre la juventud actual y demostramos, recurriendo a varios estudios sobre la música rock, la utilidad expresiva y creativa del elemento musical sobre el cual está estructurada la novela.
«Andarse por las tramas: literatura y series de televisión», de Javier García Rodríguez
Authors: Lumbreras Martínez Daniel
Published: July 2023

Reseña del libro Andarse por las tramas: literatura y series de televisión (León, Eolas & Menoslobos, Editores Descabezados, 2022), de Javier García Rodríguez.
«La Belleza impura (Poesía 1970-2021)» y «Lujurias y apocalipsis», de Luis Antonio de Villena
Authors: Pujante David
Published: July 2023

Reseña de los libros La Belleza impura (Poesía 1970-2021) (Lleida, Milenio, 2022) y Lujurias y apocalipsis (Madrid, Visor, 2022), de Luis Antonio de Villena.
«Devoraluces», de Ángel Olgoso
Authors: Rodríguez Salas Gerardo
Published: July 2023

Reseña del libro Devoraluces (Madrid, Reino de Cordelia, 2021), de Ángel Olgoso.
Paisajes agrarios durante los siglos XVIII y XIX en el este catamarqueño
Authors: Nagel Antonela , Rodríguez Oviedo Melisa , Quesada Marcos Nicolás
Published: July 2023

En este trabajo abordamos diferentes procesos sociohistóricos que entre los siglos XVIII y XIX conformaron un paisaje campesino en la serranía de El Alto-Ancasti y cuyas materialidades aún prevalecen en el entorno. Nuestro objetivo es generar información que contribuya a la historización y el entendimiento de los diferentes paisajes culturales serranos. Para ello, metodológicamente incorporamos diversas fuentes de información como los documentos históricos, el trabajo de campo arqueológico y entrevistas etnográficas. Nos centraremos aquí en dos casos que permiten abordar el proceso de transformación del paisaje agrario en El Taco, en el pastizal del sector cumbral, y Oyola, en el bosque serrano a media altura de la ladera oeste de la serranía. Caracterizaremos sucesivos paisajes productivos agropecuarios y estableceremos una genealogía de sus cambios y continuidades, relacionando las transformaciones con el devenir de las condiciones socioeconómicas a escala regional y local.
análisis de la evolución de la política energética para la transición hacia una economía baja en carbono en China de 2010 a 2020
Authors: Briones Molina Yessenia Paola
Published: July 2023

La necesidad de adoptar políticas de mitigación ambiental, la aguda dependencia de combustibles fósiles y la contaminación del aire en China han hecho necesaria la transición a un sistema energético lejos de la producción dominada por el carbón. El presente estudio tiene como objetivo hacer una revisión de las políticas adoptadas por el gobierno chino en un marco de transición energética, así como examinar las dificultades prácticas en la implementación de estas a nivel nacional, entre 2010 y 2020.
The use of Escherichia coli strain Nissle 1917 shows promise for improving gastrointestinal and urinary health in dogs
Authors: Rudinsky Adam J. , Harrison Alistair , Shi Baochen , Hardison Rachael , Prinster Tracy , Huang Stella , Lee Sonya , Byron Julie K. , Lucas Elizabeth , Mason Kevin M. , Li Huiying , Wolff Corinna , von Buenau Rudolf , Bornack Brigitte , Justice Sheryl S.
Published: July 2023

OBJECTIVES

To investigate the probiotic Escherichia coli Nissle 1917 (EcN) in canine idiopathic diarrhea and urinary tract infections.

ANIMALS/SAMPLES

The utility of EcN was explored in a 3-phase study from March 2017 to June 2020. Eighty-nine dogs with idiopathic diarrhea were included in phase 1, 3 healthy dogs were included in phase 2, and uropathogenic E coli (UPEC) isolates from 38 dogs with urinary tract infections were included in phase 3.

PROCEDURES

In phase 1, dogs with diarrhea were prospectively enrolled in a randomized study to receive EcN (108 EcN bacteria/mL; < 10 kg received 5 mL/dose, 10 to 25 kg received 10 mL/dose, or > 25 kg received 15 mL/dose) or placebo for 3 days, followed by a 15-day observation phase. In phase 2, healthy dogs received EcN as described in phase 1, with feces analyzed for E coli populations and microbiome composition at days 0, 3, and 7. In phase 3, EcN efficacy was tested by in vitro plate assay against UPEC isolates.

RESULTS

Median duration of abnormal stool consistency, time to response, and duration of diarrhea were shorter for dogs that received EcN (5.0, 3.0, and 2.0 days, respectively) versus the placebo (7.0, 5.0, and 4.0 days, respectively) (P = .21, P = .05, and P = .039, respectively). EcN induced shifts in E coli diversity in healthy dogs while having minimal impact on overall microbiome structure. Furthermore, 68% of the canine UPEC isolates were susceptible to EcN in vitro.

CLINICAL RELEVANCE

EcN improved the treatment of idiopathic diarrhea, colonized the gastrointestinal tract during the trial, and displayed in vitro competition with UPEC.
Work Safety in the Mill - Case Study
Authors: Peniak Klaudia , Nowacki Krzysztof
Published: July 2023

In many cases, old working mills, use machines that are several dozen years old, which are not adapted to the safety requirements. Their use may result in an accident at work. The article presents a case study of the work safety assessment in an old mill. The analysis was carried out with the use of a proprietary checklist, taking into account the current safety requirements. Non-conformities that were identified as the results of the analysis, had an impact on the level of security. The greatest number of non-conformities concerned the fulfillment of technical requirements. Actions aimed at improving work safety were proposed. The prepared checklist is a universal tool for assessing work safety in mills in Poland.
Solutions of the Nonlinear Evolution Problems and their Applications
Authors: Amir Muhammad , Haider Jamil Abbas , Ul Rahman Jamshaid , Ashraf Asifa
Published: July 2023

In this article, a well-known technique, the variational iterative method with the Laplace transform, is used to solve nonlinear evolution problems of a simple pendulum and mass spring oscillator, which represents the duffing equation. In the variational iteration method (VIM), finding the Lagrange multiplier is an important step, and the variational theory is often used for this purpose. This paper shows how the Laplace transform can be used to find the multiplier in a simpler way. This method gives an easy approach for scientists and engineers who deal with a wide range of nonlinear problems. Duffing equation is solved by different analytic methods, but we tackle this for the first time to solve the duffing equation and the nonlinear oscillator by using the Laplace-based VIM. In the majority of cases, Laplace variational iteration method (LVIM) just needs one iteration to attain high accuracy of the answer for linearization anddiscretization, or intensive computational work is needed. The convergence criteria of this method are efficient as compared with the VIM. Comparing the analytical VIM by Laplace transform with MATLAB’s built-in command Simulink that confirms the method’s suitability for solving nonlinear evolution problems will be helpful. In future, we will be able to find the solution of highly nonlinear oscillators.
Aerodynamic Investigation on the Artefact “Bird of Saqqara”
Authors: Zierow Michel , Lesemann Leon
Published: July 2023

Lost, technical knowledge of ancient cultures is being rediscovered in modern times during archaeological excavations. A presumed example of the innovative power of ancient cultures is the artefact “Bird of Saqqara”. In the context of this paper, the aerodynamic characteristics of the artefact are to be determined by a computational fluid simulation, in order to be able to make a statement about the actual flight suitability and to examine the theses of the pre-astronautics critically. Based on a 3D scan, a CAD model of the artefact is created and then a numerical flow simulation is performed. By varying the angle of attack, the dimensionless coefficients can be represented in corresponding polars. The results show that the artefact has a low maximum glide ratio and thus the glide properties are not sufficient for use as a handglider. The centre of gravity of the artefact is located at the trailing edge of the wing and behind the neutral point. The resulting longitudinal stability does not meet modern specifications. Asymmetric lift distribution in the spanwise direction results in uncontrolled roll. Consequently, the artefact cannot fly a straight path. Within the scope of this work, the connection between the “Bird of Saqqara” and an alleged knowledge of aerodynamics in ancient Egypt could not be confirmed.
An Empirical Approach to Optimize Nonlinear Problems of Domestic Energy Management Systems
Authors: Carreras Fernando , Kirchsteiger Harald
Published: July 2023

Numerical optimization methods are used to reduce the operative costs and emissions of domestic houses comprising photovoltaic energy production and battery electrical storage combined with time-variant electricity prices. The modelling of the system comprises the different involved devices, energy flows and their constraints, and an objective function, which parametrizes the object of the optimization. The solution of the optimization problem defines the most adequate charging and discharging strategy of the battery into the future (prediction horizon). Power inverter efficiencies are usually modelled by assuming that they have constant values, and hence, that charging and discharging energy-flows lie on the most probably operating region of the inverter. A more realistic modelling of the power inverter efficiencies should consider a nonlinear parametrization of the efficiency curves. This consideration converts the optimization problem into a nonlinear one. It this paper, we modify a method to solve nonlinear optimization problems means iterations of linear optimization problems. The first iteration uses as seed values the solution of an optimization problem, which considers constant efficiencies of the battery inverter provided by the manufacturer of the battery. With the values of the solution of the optimization problem and with help of measured (dis)charging power curves and the optimized (dis)charging, new values of the efficiencies of the inverter of the battery will be determined, and the optimization problem will be with these values again computed. If a certain number of iterations is achieved or the values of the efficiencies converge, then the process stops.
Genetic diversity and mating system of Euterpe precatoria in three localities along the lower Solimões River in Central Amazonia
Authors: Perrut-Lima Poliana , Sebbenn Alexandre Magno , Francisconi Ana Flávia , Picanço-Rodrigues Doriane , Clement Charles Roland
Published: July 2023

Euterpe precatoria is a Neotropical palm from South and Central America and is hyperdominant in Amazonia, where it is increasingly important in the Brazilian market for açaí. Genetic diversity, population structure and mating system of E. precatoria were characterized with 10 microsatellite markers in three localities (Codajás, Manacapuru, and Manaquiri) along the lower Solimões River, Amazonas, Brazil. Leaves of 63 mature palms were collected, as well as fruits from 30 of these to analyze 20 seedlings per progeny. Genetic differentiation across localities was substantial (G
S
′ = 0.304) for mature palms, suggesting that gene flow is restricted between localities due to isolation by distance. Inbreeding was significant in progenies from all populations (ranging from 0.059–0.076), but not for mature palms, suggesting selection for heterozygosity during maturation to the adult stage. The outcrossing rate was high (0.917–1.0), confirming that the species is predominantly allogamous. Matings were not random due to the occurrence of biparental inbreeding (0.021–0.079) and correlated matings (0.059–0.424), so open-pollinated progenies present mixtures of self-sibs, half-sibs, full-sibs, and self-half-sibs, resulting in mean effective population size within progenies (2.23–3.06) lower than expected for a random mating population. The mating system’s characteristics are those expected in a predominantly allogamous hyper-abundant palm and suggest that human management of these often-anthropogenic populations is unlikely to reduce genetic diversity in the short term if done in situ, as practiced by Indigenous Peoples and local communities. Intensification will require careful attention to maintain genetic diversity.
Prácticas de consumo sustentable de alimentos en estudiantes universitarios de Hermosillo, Sonora, México.
Authors: Romero-Valenzuela Denisse Mercedes , Camarena-Gómez Beatriz Olivia
Published: July 2023

Objetivo: describir los principales factores sociales que delimitan las prácticas de consumo sustentable a través del análisis del comportamiento de consumo de alimentos en estudiantes universitarios. Metodología: el diseño de investigación fue tipo cualitativo, alcance descriptivo y diseño transeccional no experimental, la información se obtuvo de entrevistas grupales realizadas a estudiantes de tres Instituciones de Educación Superior (IES) de la ciudad de Hermosillo Sonora, elegidos por participar en la promoción de acciones ecológicas. Las transcripciones de las sesiones se categorizaron según la revisión teórica. Resultados: las prácticas de consumo sustentable que suelen practicar los estudiantes se relacionan con el cuidado de los recursos del hogar (ingresos familiares). Entre los factores sociales de mayor influencia en tal agencia colectiva está la familia en primer lugar, seguida por los compañeros universitarios y las IES a través de sus diversos programas. Limitaciones: el estudio se realizó en período de pandemia y lo que aquí se presenta son resultados parciales de una investigación en proceso. Conclusiones: la investigación aporta conocimiento empírico a modelos teórico-analíticos propuestos para estudiar el consumo, en este caso, las prácticas de consumo de alimentos en estudiantes universitarios. Se observó que las prácticas de consumo sustentables son incipientes aún y cuando todos los centros han desplegado algunas acciones para impulsarlas; la principal barrera o limitante que enfrentan las prácticas de consumo sustentable son los valores que están arraigados a la cultura alimentaria del sonorense que, por ejemplo, incentiva el consumo de carnes rojas.
Akademisierung der Psychotherapie
Authors: Datler Wilfried , Drossos Alexandra , Gornik Elke , Korunka Christian
Published: July 2023

1991 wurde das Tätigkeitsfeld der Psychotherapie in Österreich erstmals gesetzlich geregelt. Seither gab es viele Entwicklungen, die zu einer Diskussion der Neufassung des Psychotherapiegesetzes führten. In diesem Zusammenhang kommt der Akademisierung der Psychotherapie besonderes Gewicht zu. Im vorliegenden Buch wird der Frage nachgegangen, wie die Akademisierung der Psychotherapie sinnvoll umgesetzt werden kann und welche Entwicklungen vermieden werden sollen. In Verbindung damit wird dem Für und Wider von Kooperationen zwischen anerkannten fachspezifischen Ausbildungseinrichtungen und Universitäten unter Einbeziehung von Erfahrungsberichten nachgegangen. Weitere Beiträge stellen Verbindungen zu historischen Entwicklungen und internationalen Diskussionen her – und werfen einen kritischen Blick auch auf die aktuellen Entwicklungen in Deutschland.
PENGARUH STRATEGI KOMUNIKASI, KUALITAS WEBSITE DAN KONTEN MEDIA INSTAGRAM TERHADAP CITRA PEMERINTAH KOTA DENPASAR PADA BAGIAN PROTOKOL DAN KOMUNIKASI PIMPINAN SEKRETARIAT DAERAH KOTA DENPASAR
Authors: I Wayan Agus Yuliawan  , I Nyoman Yoga Segara  , I Gede Sutarya
Published: July 2023

The use of social media, particularly Instagram by local government can quickly reach everyone. Through social media, the government can provide direct and open contributions, get feedback, allow commenting and share information quickly and without limits. This research aims to determine the effectiveness of using Instagram to improve the image of the Denpasar City Government through interactions and feedback from social media followers as a form of public information openness, implemented by the Public Relations Department in responding to news and promoting a positive image in the community. This research found that Communication Strategy, Website Quality and Instagram Content have an impact on the Government's Image. Although each independent variable can influence the dependent variable, significant results will only occur if all variables are implemented optimally.
STRATEGI KOMUNIKASI HUMAS MELALUI MEDIA SOSIAL INSTAGRAM DALAM MEMBANGUN CITRA POSITIF PEMERINTAH KOTA DENPASAR
Authors: Ni Luh Putu Diah Desvi Arina  , I Wayan Wastawa  , I Wayan Suyanta
Published: July 2023

Organizational image is defined as the public's perception of an organization in its public memory. This makes a positive image must be built and maintained by an organization, institution including government agencies. This study aims to analyze the management of government social media, especially public relations through Instagram social media in building a positive image of the Denpasar City Government. This research uses a qualitative approach which is carried out through content observation on the Denpasar City Public Relations account, namely the @joyful.denpasar account and conducting interviews with the Head of Public Relations and Leadership Communications, Denpasar City Government, interviews with Instagram account managers @joyful.denpasar, and public relations consultants. The next process is data analysis and described in the form of an actual explanation. The results showed that the process of implementing the Public Relations communication strategy through Instagram social media in building a positive image of the Denpasar City Government, went through several stages starting from planning the communication strategy, implementing the communication strategy, to the evaluation stage. The obstacles encountered by Denpasar City Public Relations in implementing a communication strategy in building a positive image, namely internal obstacles, including the lack of human resources for communication graduates, and the limited availability of adequate tools, while external obstacles, namely there are still fake accounts or fake accounts. However, there are several steps taken by Denpasar City Public Relations to overcome these obstacles, namely first planning, organizing, actuating, and controlling. So that these obstacles can be minimized. The implications of the Denpasar City Public Relations communication strategy through Instagram social media in building a positive image, including making account activityjoyful. denpasar as an account that provides positive information, and becomes the official information media for the Denpasar city government that is able to provide reliable, up-to-date and up-to-date information.
LAYANAN BIMBINGAN KONSELING ANAK USIA DINI DENGAN TEKNIK SPICC UNTUK MENINGKATKAN RASA PERCAYA DIR
Authors: Amni Sri Sofiana , Lestari Ni Wayan Ria
Published: July 2023

Tujuan penelitian ini adalah untuk mengaplikasikan bimbingan konseling pada seluruhsatuan tingkat pendidikan utamanya pada anak usia dini. Karena pembelajaran sertapengalaman belajar yang diterapkan pada pendidikan anak usia dini dapat mempengaruhiperilaku anak pada jenjang pendidikan selanjutnya baik di tingkat sekolah dasar,menengah, bahkan sampai jenjang perguruan tinggi. Oleh karena itu, model layananbimbingan konseling anak usia dini yang dilengkapi dengan teknologi SPICC(Sequentially Planned Integrative Counselling for Children) diperlukan untukmeningkatkan kepercayaan berdasarkan hasil penelitian awal yang diperoleh dandidukung oleh pendapat ahli. Penelitian dikembangkan menggunakan prinsip sertatahapan Borg dan Gall. Hasil yang diperoleh berdasarkan pengamatan yang penelitilakukan yaitu: (a) tingkat rasa percaya diri anak usia dini di Kelompok Bermain (KB)Gemilang secara keseluruhan sebelum diberikan perlakuan memiliki kategori sedang,namun ketika telah diberi perlakuan tingkat rasa percaya diri anak meningkat di leveltinggi. (b) teknik SPICC (Sequentially Planned Integrative Counselling for Children)menghasilkan layanan bimbingan konseling anak usia dini yang mengakibatkan rasapercaya dini anak menjadi meningkat. Teknik ini sendiri tersusun dalam 7 lapisan bagiandiantaranya: bersifat rasional, adanya visi dan misi, memiliki tujuan, isi layananbimbingan konseling AUD menggunakan teknik SPICC (Sequentially PlannedIntegrative Counselling for Children), terdapat dukungan sistem, prosedur layananbimbingan konseling AUD dengan teknik SPICC (Sequentially Planned IntegrativeCounselling for Children), adanya evaluasi dan monitoring. (c) model layanan bimbingankonseling AUD menggunakan teknik SPICC (Sequentially Planned IntegrativeCounselling for Children) sangat cocok diterapkan sehingga rasa percaya diri anak diKelompok Bermain Gemilang meningkat.
KENDALA GURU PAUD MENGAJAR PADA MASA PANDEMI COVID-19 DI TK SE-KECAMATAN KALIORANG
Authors: Rahardjo Budi , Rusdiana Yunita , Palenewen Evie , Rozie Fachrul
Published: July 2023

Penelitian ini dilatarbelakangi oleh dampak pandemi COVID-19 yang ditinjau dari proses pembelajaran yang dirasakan oleh pendidik PAUD. Penelitian ini bertujuan untuk mengetahui kendala internal dan eksternal serta strategi dalam mengatasi kendala mengajar online. Jenis penelitian ini adalah penelitian kualitatif dengan menggunakan pendekatan studi kasus. Pengumpulan data dalam penelitian ini menggunakan teknik observasi, wawancara, dan dokumentasi. Analisis data menggunakan model Miles & Hubberman. Hasil penelitian menunjukkan bahwa (1) Guru tidak siap dalam mengajar pada masa pandemi karena guru tidak mampu menyediakan seluruh perangkat pembelajaran secara lengkap.(2) Kendala ekternal yang guru rasakan selama mengajar daring, diantaranya kurang berpartisipasi orang tua dalam mendampingi anak, keterbatasan fasilitas sarana dan prasarana di rumah, dan ketidakstabilan jaringan internet. (3) Strategi yang guru lakukan dalam mengatasi orang tua yang kurang berpartisipasi dalam mendampingi anak belajar di rumah dengan menelfon orang tua, kurangnya fasilitas belajar di rumah, anak dapat mengambil dan mengirimkan tugas ke sekolah, dan keterbatasan jaringan internet dengan mencari tempat yang memiliki jaringgan internet yang stabil. Dengan demikian, hasil penelitian ini dapat digunakan sebagai bahan kajian tentang ganbaran dari kendala dan setrategi guru dalam mengajar dimasa pandemi COVID-19.

Kata Kunci: Kendala Guru PAUD, Mengajar Daring , Masa pandemi COVID-19
STIMULASI TARI KREATIF DALAM MENINGKATKAN KEMAMPUAN SOSIAL ANAK TAMAN KANAK-KANAK
Authors: Antara Putu Aditya , Dewi Ni Putu Sinta , Ari Putri Ni Nyoman Chintya
Published: July 2023

Tujuan penelitian ini adalah untuk mendapatkan informasi dan data tentang upaya untuk meningkatkan kemampuan sosial anak melalui kegiatan gerak kreatif di kelompok B2 Taman Kanak-kanak Lab School, Singaraja, Bali, dengan jumlah anak sebanyak24 orang. Penelitian ini dilaksanakan pada tahun 2018. Metode yang digunakan adalah metode Kemmis dan Taggart yangterdiri dari perencanaan, tindakan, observasi, dan refleksi. Teknik pengumpulan data yang digunakan adalah observasi,wawancara, catatan lapangan, instrumen pemantau tindakan dan dokumentasi. Analisis data disajikan secara kuantitatif dankualitatif. Hasil data secara kuantitatif menunjukan bahwa keterampilan sosial anak dapat meningkat setelah dilakukan tindakanmelalui tari kreatif. Hal ini dapat dilihat dari hasil penelitian yang menyebutkan bahwa rerata kelas pada pra tindakan sebesar49,30%. Setelah dilakukan tindakan dalam siklus I meningkat rerata kelas menjadi 71,18% dan siklus II meningkat menjadi84,42%. Dari  hasil  penelitian  ini  maka  dapat  disimpulkan gerak kreratif dapat meningkatkan kemampuan sosial anak.
Chai’s Play, Aplikasi Parenting dan Permainan Milenial untuk Aktivitas Tumbuh Kembang Anak Usia Dini
Authors: Indrayasa Kadek Bayu , Suryanti Putu Emy
Published: July 2023

Ibu dengan rentang usia kurang dari 35 tahun aktif mengakses media karena sedang dalam proses menjadi orang tua baru. Menjadi bagian dari generasi milenial menuntut mereka untuk menjadi generasi baru yang mengacu pada generasi sosial dengan rentang usia yang kurang lebih sama untuk berbagi informasi tentang kehidupan keluarga dan dinamika di dalamnya. Informasi di berbagai laman digital merupakan jawaban atas kebutuhan yang dilalui seseorang dalam menghadapi fase kehidupan baru. Pergeseran perolehan informasi didukung oleh perkembangan media dengan berbagai jenis dan fitur yang ditawarkan. Akses informasi yang semula dilakukan secara langsung melalui teguran orang tua atau lanjut usia, kini dengan mudah mencari di internet segala informasi yang dibutuhkan dalam mengasuh anak.

Chai's Play merupakan salah satu aplikasi parenting untuk orang tua dengan konten yang mengedepankan konsep anak usia dini “belajar sambil bermain”. Aplikasi ini berisi berbagai ide permainan edukasi untuk anak dan info parenting. Isi permainan edukatif yang ditawarkan sangat beragam, antara lain permainan enam aspek perkembangan anak usia dini, kelekatan, dan lain-lain. Keenam aspek tersebut adalah aspek perkembangan nilai agama dan moral, kognitif, sosial-emosional, bahasa, fisik motorik, dan seni.