bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular disturbances of erythrocytes membrane during pathology of different genesis are the typical reaction of the organism: contours of the problem
Authors: Novitsky V. V. , Ryazantseva N. V. , Stepovaya Ye. A. , Fyodorova T. S. , Kravets Ye. B. , Ivanov V. V. , Zhavoronok T. V. , Chasovskikh N. Yu. , Choudakova O. M. , Butusova V. N. , Yakovleva N. M.
Published: April 2021

General patterns and peculiarities of changes in structure and function of red blood cell’s membrane during pathology of different genesis are considered in the article. Based on literature data and our own investigations one concludes concerning presence of typical molecular disturbances of erythrocyte’s membrane in different diseases. But general character of molecular modification of plasmatic membrane during pathology of different genesis is controversial. Universal mechanisms of structural and functional modification of structure and function of cells’ membrane are considered in details.
The role of μ-opioid receptors in the regulation of hepatic secretory function
Authors: Medvedev M. A. , Rudin I. V. , Garayeva A. F.
Published: April 2021

Influence of intraperitoneal and intracerebroventricular DAGO (μ-opioid agonist) on the bile secretion and composition was studied in white rats having intact and denervated liver. DAGO was demostrated to alter bile composition significantly both intraperitoneally and intracerebroventricularly and these effects were opposite. Intact liver innervation is a necessary condition for intracerebroventricular DAGO to have its effect on bile secretion.
Cytotoxic potential of eosinophiles’ granulocytes in patients having eosinophilia syndrome
Authors: Litvinova L. S. , Kolobovnikova Yu. V. , Knoutareva Ye. N. , Grigoryeva Ye. S. , Souvorova Ye. V. , Novitsky V. V. , Ryazantseva N. V.
Published: April 2021

In malignant diseases of blood system and opisthorchiasis (sharp and chronic), significant strain of microbicide mechanisms of eosinophilic row leukocytes causes forming their high cytotoxic potential action of which could be realized concerning not only antigenic structures but also macro-organism cells which can result in damaged tissues.
Structure of pulmonary non-elastic resistance in community-acquired pneumonia
Authors: Bodrova T. N. , Tetenev F. F. , Ageyeva T. S. , Levchenko A. V. , Larchenko V. V. , Danilenko V. Yu. , Kashouta A. Yu.
Published: April 2021

70 community-acquired pneumonia (CAP) patients and 50 healthy individuals were examined with the identification of general non-elastic resistance (GNR), aerodynamic resistance (40 CAP patients и 30 healthy individuals), bronchial resistance (Raw) (30 CAP patients и 20 healthy individuals), fabric friction (FF). Raw was identified as being within due values. GNR was high due to the FF increase.
Clinical-epidemiologic characteristic of insults in Tomsk
Authors: Nikolayeva T. N. , Alifirova V. M. , Titova M. A.
Published: April 2021

Epidemiologic indices of brain insult using register method based upon recommendation of National Association on insults fight are studied. Morbidity, mortality and lethality from insults is shown taking as an example an open population of Kirovski region of Tomsk. Main risk factors and their influence on the disease outcomes are revealed.
Organization of in-house hospitals
Authors: Kalinkin D. Ye. , Tereschenko T. A. , Khlynin S. M. , Astafurov A. N.
Published: April 2021

The problems of organization of a hospital-replacing technologies — in-house hospital — are investigated. The data of investigations of different authors on the following issues are incorporated and systematized: history of the home visiting service; purposes and problems of in-house hospitals; forms of organization of the diagnostic and treatment process.
Estimation of relations between breathing perception, breathing patterns and the respiratory biomechanics in persons with various ventilator possibilities of the respiratory system at respiratory therapy
Authors: Karzilov A. I. , Tetenev F. F. , Bodrova T. N.
Published: April 2021

The data obtained have attributes of fundamental investigation with the evidence-based level C. The relations between the breathing perception, dispnoea, respiratory center (RC) functioning and respiratory mechanics have been studied in healthy persons (HP, n = 20), patients with bronchial asthma (BA, n = 30) and chronic obstructive pulmonary disease (COPD, n = 30) at an electrical stimulation of diaphragm (ESD) and subsequent inhalations of the bronchodilator Berodual. Descriptive, comparative, correlative, canonical, cluster, factorial, regressive and informative analysis of the results has been performed. It has been found that ESD and Berodual have the adaptable action on the sensory parts of the central nervous system (SPCNS) and functioning of RC. On the basis of the correlations obtained, structural models of the functional biomechanical systems of the respiratory system (RS) adjusted by RC, in HP, BA patients and COPD patients are proposed. Peculiarities of the models of functioning SPCNS, RC and RS in HP, BA patients and COPD patients have been described qualitatively.
Medicines of symbolical action in cultural experience
Authors: Kirilenko Ye. I.
Published: April 2021

Modern methodology offers theoretical toolkit which allows us to investigate the culturally - significant constants in the inter- nal experience of the person. Here belong the concepts of experience, medical experience, archetypes of the collective unconscious, the vital world. The address to the mythological tradition, the vital world of the person of traditional culture allows us to single out the steady structures, to find out the universal medical archetypes in medicinal sphere, and thus to investigate, a phenomenon of «medicines of symbolical action» (M. Foucault).
On philosophy of age. Fractal structure of life and periodic table of ages
Authors: Epstein M. N.
Published: April 2021

The article represents the fractal age theory, where the terminology of nonlinear dynamics (synergetic) obtains figural sense.
Freedom and responsibility levels: systems analysis
Authors: Sagatovsky V. N.
Published: April 2021

There are three essential freedom interpretations. They are represented as complementary levels of integral freedom compre- hension. The first level is represented with the outer trends of existence and civil responsibility perception. This level objectifies the art implementation of the free choice. Human freedom as the choice and responsibility for it is carried out at the second backbone level — the level of freedom and responsibility as an entire phenomenon. The third top level is forming with a presence of the Spirit in human choice tendency and creativity, who accepts the responsibility before the entity spiritual reasons. Human soul mission, sacring by the Spirit presence, is free and liable the man, the word, the objective and subjective actuality advancing. Though this fundamental choice between Good and evil only by man himself could be made.
Obstetrics and gynecology chair of the SibSMU: 115 years of pedagogical, scientific and practical activity
Authors: Yevtushenko I. D. , Nekrylov S. A. , Bolotova V. P. , Makhmoutkhodzhaev A. Sh.
Published: April 2021

History of establishment, development and current status of one of the oldest chairs of the Siberian State medical University, chair of obstetrics and gynecology which marks by celebration its 115th anniversary is presented in the article.
Opening and initial activity of faculty clinicsof the Siberian State Medical University
Authors: Tetenev F. F. , Karzilov A. I.
Published: April 2021

Detailed data concerning opening and initial activity of faculty clinics of the Siberian State Medical University, data on the Siberian school of therapists are presented in the article.
Morphology of autolymphocytes used in the treatment of trophic ulcers in the setting of diabetic foot syndrome
Authors: Lyubarsky M. S. , Shoumkov O. A. , Khabarov D. V. , Bgatova N. P. , Kamenskaya O. V.
Published: April 2021

Diabetic foot syndrome is one of the most often chronic and severe complications of diabetes mellitus. Method of local treat-ment of trophic ulcers and wounds in the setting of diabetic foot syndrome using autolymphocytes processed by leukinoferon was developed in the Institute of Clinical and Experimental Lymphology (Novossibirsk). Autolymphocytes were obtained by lymphocytapheresis on the blood cell separator «Haemonetics MCS+». The study of ultrastructural organization of identified lym-phocytes processed by leukinoferon did not reveal any disturbances of their structural integrity. Numerical density free polysomal ribosomes increased by 50%. Volumetric density of vesicular structures in cytoplasm of lymphocytes increased by 3 times. Number of excrescences and microvilli formed by plasmatic membrane increased by 2,4 times. Thus, technologies of autolymphocytes iden-tification do not result to damaged structure of cells. Processing of the lymphocytes by leukinoferon does not cause cellular damage but promotes development of structural changes.
Phenotypic profile and factors of blood lymphocytes apoptosis induction in patients having diffuse toxic goiter
Authors: Ourazova O. I. , Kravets Ye. B. , Novitsky V. V. , Rogalyova A. V. , Vasilyeva O. A. , Nedosekova Yu. V. , Barmina S. E.
Published: April 2021

Peculiarities of phenotypic structure and factors of apoptosis induction (level of CD95-antigen cell expression, blood serum content of TNF-α ) of peripheral blood lymphocytes in patients with diffusive toxic goiter are discussed in thе article.
Evaluating the prevalence of hemoblastosis among the children of Seversk
Authors: Karpov A. B. , Takhauov R. M. , Pisarev L. F. , Korolyov N. V.
Published: April 2021

Leukemia (71,2%) brings the basic contribution to the structure of hemoblastosis. The indices of leukemia disease both boys and girls of Seversk exceed the same ones in Tomsk in the age groups of 0-4 and 10-14; though according to the reliable information it is shown only at boys. It is established that the boys morbidity of hemoblastosis in Seversk exceeds the same one in Tomsk only in the age group of 0-4.
The development of quality management system in the Scientific-medicallibrary of the Siberian State Medical University
Authors: Terekhova M. V.
Published: April 2021

Issues of the development of quality management system in the scientific medical library are considered. Key idea of the quality management system is using process model of control. Essence of process approach in the library of the Siberian State Medical University is reorientation of its activity to the creation of system of the library control based upon corporative control of processes.
Hemomicrocirculation and immune structural components changesin Chernobyl accident liquidators
Authors: Tetenev F. F. , Porovsky Ya. V. , Bodrova T. N. , Ryzhov A. I. , Vetlugina T. P.
Published: April 2021

The aim of the study was to investigate correlation of immunity structural components (morphologic-functional changes in derma and systemic immune reactionof the organisms of Chernobyl accident liquidators. In 2000-2002, we examined 49 Chernobyl accident liquidators with admitted with coronary artery disease and hypertension. Controls were 61 men who had the same diseases and risk factors but were not under radiation. Immunologic data of 106 practically healthy men is were used normal indices. The derma biopsy was made in 24 Chernobyl accident liquidators; for morphologic control, the skin of 12 autopsy men who were not under radiation. The immunologic study data revealed reliable increase of СD8+ and circulating immune complexes, decreased СD16+, СD72+, IgM, saturation capability of neutrophils; proliferative inflammation of derma vessels and lymphocyte infiltration were seen. All these data show that immune -pathological processes take place in vascular changes mechanisms in these patients and allow to consider radiation as independent risk factor of systemic vascular changes.
The correction of disorders of the lactational function and qualitative contentof milk of puerperas, suffered from preeclampsia
Authors: Gutikov L. V. , Keda L. N.
Published: April 2021

The aim of the research is estimation of efficiency of measures for correction of disorders of the lactational function and qualitative content of milk of puerperas suffered from preeclampsia. There were examined 64 puerperas, who had normal pregnancy and 180 puerperas suffered from preeclampsia and there was made estimation of the lactational function and content of basic nutrients in mature breast milk. On the 6th day of puerperium, there was revealed evident disorders of the lactational function and decrease in continuance of the lactational period associated with decrease of general quantity of proteins, serum fats (general lipids, triglycerides, cholesterine and phospholipids), carbohydrates, macro- and microelements according to the level of severity of preeclampsia. After carried out treatment (motilium, phytotea, apilac, vitamins A and E, dry milk product) of 14 days there was discovered increase in daily quantity of milk, continuance of the lactational period and almost liquidated deficiency of basic nutrients in breast milk.
Radical treatment of liver echinococcosis. State of art
Authors: Vishnevsky V. A. , Ikramov R. Z. , Kakharov M. A. , Yefanov M. G.
Published: April 2021

purpose of this study is to evaluate the results and role of radical operations in the management of hepatic hydatid disease. 317 patients with liver hydatid cysts underwent surgical treatment. Liver resection, total and subtotal pericystectomy were possible in 215 patients (67,8%). There were 115 patients (36,3%) with complicated hepatic hydatid cysts. Residual echinococcosis was indication for operation in 17%. Among all patients 53 (16,7%) presented other anatomic sites of parasite such as lung, peritoneum, kidney, and other viscera. The postoperative complication rate was 25,7% after operations without pericystectomy, 17,6% - after radical operations and 19,8% - after combined operations. The mortality rate was 1,6%. The recurrence rate was 6,7%. Removal of cystic and pericystic tissue and liver resection are the only type of operations for safe and radical treatment of liver hydatid cysts, especially in the cases of complicated and relapsing disease.
Afterhistory of surgical treatment of nodular goiter
Authors: Petrov V. G. , Malinin D. I.
Published: April 2021

Long-term results of surgical treatment of 649 patients with different morphological forms of nodular goiter in terms of 15 to 3 years are analyzed. Postsurgical recurrent goiter was diagnosed in 26.8% (174 people). The most part of relapses falls on operations characterized by the large part of TG tissue rest (resection of TG lobe and node enucleation): 69.1% (139 patients of 201). No one relapse was diagnosed after thyreoidectomy. After extremely subtotal resection, relapses were observed in 2.2% (7 people of 312) and after hemithyroidectomy in 20.6% (26 people of 136). This study indicates inadequacy of operations such as node enucleation and resection of the lobe with a node, especially, if the node belongs to nodular colloid goiter, because in such operations the pathologically changed TG tissue is often rest and there is high probability of relapse.
Risk factors for bronchial asthma in children in Chita Region
Authors: Gaimolenko I. N. , Potapova N. L.
Published: April 2021

Risk factors for bronchial asthma in children of Chita Region were studied. According to the literature data, 12 clinical-anamnestic characteristics were suggested to be risk factors for bronchial asthma. Prevalence of risk factors was assessed in 72 children with severe asthma, 60 children with moderate, and 58 children with mild bronchial asthma. Odds ratios (OR) with the 95% confident interval for each factor were calculated. Factors with predominance in the asthma group included: parental history of asthma (OR = 16.2), congenital abnormalities and complications of pregnancy and labor (OR = 1.9), prenatal lesion of central nervous system (OR = 2.8), recurrent respiratory tract infections (OR = 12.4), coexisting atopic dermatitis (OR = 1.8), passive smoking (OR = 2.8), and food sensitization (OR = 7.7). The findings can be used to calculate individual risks in a population for prediction of development of this pathology and for its timely prevention.
Role of blood plasma fatty acids in pathogenesis of stable anginapectoris
Authors: Novitsky V. V. , Karpov R. S. , Klimenkov S. V. , Salmina A. B. , Kotlovsky M. Yu. , Mashkovskaya S. V. , Kirichenko D. A. , Butyanov R. A. , Kouskaev A. P. , Bolshakova Ye. V. , Kotlovsky Yu. V.
Published: April 2021

In men and women suffering from stable angina pectoris of 1-2 functional classes and aged from 35 to 69 years old, decrease of C 23:0 and increase of C 18:1(11) fatty acids was observed regardless of sex, the content of the rest fatty acids changed depending on patients sex. Correlation was found that metabolism of fatty acids in this pathology group depends on patients sex: men in the control group showed decrease in the sum of omega-3 fatty acids as well as in the omega-3/omega-6 fatty acid ratio, while women showed decrease of omega-6 fatty acids at the constant sum of omega-3 fatty acids. Regardless of sex, the presence of this pathology is accompanied with decrease in correlations between fatty acids, as the number of correlations between saturated fatty acids increases and the number of correlations between not saturated and saturated fatty aсids decreases. Change in correlations between not saturated fatty acids depends on sex. In the number of patients having supernormal fatty acid contents, no pronounced differences were found between men and women.
Autonomic nervous system and status of erythrocytesin patients with disfunctional uterine bleeding
Authors: Sotnikova L. S. , Shevtsova N. M. , Dygai A. M. , Udut V. V. , Zhdanov V. V.
Published: April 2021

This project studies peripheral erythron component in 160 patients with juvenile uterine bleeding depending on the tone of the autonomic nervous system. We found the following changes in morphology and functional status of erythrocytes: decrease of their dry weight and increase in number of transformed and degenerative forms. Cytochemical studies revealed a decrease in sulfa radicals in erythrocytes of these patients. These changes were particularly noticeable in cases of high sympatic tone of the autonomic nervous system.
Pathogenesis of chronic heart failure: change of dominating paradigm
Authors: Kalyuzhin V. V. , Teplyakov A. T. , Vechersky Yu. Yu. , Ryazantsevа N. V. , Khlapov A. P.
Published: April 2021

The review considers literature data reflecting the evolution of views on pathogenesis of chronic heart failure. Connection of revision of a dominating paradigm of pathogenesis at every stage of development of cardiology with changes in approaches to therapy of chronic heart failure is analyzed.
Clinical and prognostic aspects of researching of neurospecific enolasa and protein S100 concentration in tick-borne infections in children
Authors: Galieva G. Yu. , Poponnikova T. V. , Fedoseyeva I. F.
Published: April 2021

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Screening of hemophilia patients for detection of inhibitors to fibrillation factors and development of personified treatment
Authors: Zozulya N. I. , Severova T. V.
Published: April 2021

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Basis of long-term perspective of prophylaxis and treatmentof tick-borne encephalitis
Authors: Tolokonskaya N. P. , Spiridonov E. A. , Kazakova Yu. V. , Provorov V. V. , Druzhinina Ye. V.
Published: April 2021

A reflection of natural population interactions between tick-borne encephalitis virus and a human being on condition of mutual adaptation appears to be a frequent persistence of an agent and a high human disease resistance. Mixed somatic pathology of degenerative nature, which was revealed in the study of the majority of patients with tick-borne encephalitis, more often including the initial central nervous system affliction under conditions of negative changes of organism reactivity, is regarded as one of the main reasons of infection conversion into disease. The virus becomes an aggression factor at such joint biological causes, changing endobiocenosis, which is of great importance for substantiation of curing therapy.
Dermatoglyphical and psychophisiological features in practically healthyadolescents of Podilya Region of Ukraine
Authors: Moroz V. M. , Gunas I. V. , Serheta I. V.
Published: April 2021

The aim of our research is to get normative standards among inhabitant teenagers through the deeply exploration of the dermatoglyphical and psychophisiological features for future complex studies of pathological changes and diseases. The following problems were evaluated for consciousness of our aim: 1) practically healthy adolescents of the slovyan ethnic group of the third line, which live in Podilya Region of Ukraine, were selected after complex researches; 2) important dermatoglyphical features of the teenagers were studied; 3) psychophisiological characteristics of boys and girls were explored. Sexual differences of palms and fingers dermatoglyphy, age depended psychophisiological characteristics of the adolescents have been studied.
The new complex method of treatment central retinal veinand branch of retinal vein occlusion
Authors: Petrachkov D. V.
Published: April 2021

The new treatment method of central retinal vein and branch of retinal vein occlusion, consisting of epiretinal injection of gemasa combined with standard pharmacotherapy was developed. Clinical researches were carried out by the group of 42 patients with central retinal vein and branch of retinal vein occlusion. The control group was appeared by 62 patients. Based on findings we can draw a conclusion, that the application of a suggested method allows to receive more stabile medical effect and reduce the number of complications.
The long term injection influence of medication called «Kumasid» on internal rat’s conditions (pathomorphological investigation)
Authors: Belousov M. V. , Novozheeva T. P. , Akhmedzhanov R. R. , Yusubov M. S. , Guryev A. M. , Mustafina L. R. , Aminin D. L. , Stonik V. A.
Published: April 2021

Pathomorphological investigation of influence on rat’s internal conditions, that were subjected to injection of medication called kumasid for prophylactic immunization extracted from Cucumaria japonica was made. It was determined that the kumasid medication dosed 1—100 mkg/kg administrated to rats intragastically during three monthes doesn’t influence on internal conditions of rats.
Ublic health in Yakutia within 1930—1940: provision with medical personnel
Authors: Nikolayev V. P.
Published: April 2021

Historical data of provision with personnel of public health service in Yakutia within 1930—1940 have been introduced. Arrival of experts from central and Siberian regions of Russia was of great significance of that period.
The role of cardiomyocyte apoptosis in mechanisms of ischemic myocardial remodeling
Authors: Khlapov A. P. , Vechersky Yu. Yu. , Ryazantseva N. V. , Kalyuzhin V. V. , Mustafina L. R. , Shipulin V. M. , Novitsky V. V.
Published: April 2021

Here the role of cardiomyocyte apoptosis in mechanisms of ischemic myocardial remodeling was investigated. The samples of left ventricle were obtained on 50 patients with the diagnosed atherosclerotic disease of coronary arteries and heart failure. Obtained data allow to approve about the maximal importance of cardiomyocyte apoptosis at an early stages of ischemic myocardial remodeling. The role of cardiomyocyte apoptosis was decreased at a high volume of left ventricle. The received results suggest about an importance of cardiomyocyte apoptosis as an marker of ischemic myocardial remodeling and heart failure.
Methodological features of medicolegal examination at artificial illnesses of a skin and hypoderm
Authors: Alyabyev F. V. , Yakunina M. A. , Shamarin Yu. A. , Poverinov S. N.
Published: April 2021

In article classification of the basic artificial illnesses of a skin and hypoderm, and also methodology of carrying out of medicolegal examination in cases, suspicious on simulation and self-damage is submitted. The basic ways of causing of artificial illnesses of a skin are described.
Osteopenic syndrome at diffuse-toxic goiter
Authors: Kravets Ye. B. , Zavadovskaya V. D. , Nochevnaya L. B.
Published: April 2021

Bone metabolism at diffuse-toxic goiter (DTG) ahs been analyzed, and diagnostic significance of revealed disorders has been assessed. The results of investigation of 40 patients aged from 18 to 45 indicate that bone resorption at DTG proceeds faster than bone formation, and this leads to demineralization of the bone tissue. The effect of sex and thyrotoxicosis duration on the bone density is proved.
Lipid content in blood serum at extended burns in children of different age
Authors: Artemiyev S. A. , Kamzalakova N. I. , Bulygin G. V.
Published: April 2021

Revealed peculiarities of the lipid spectrum of blood serum in children of different age groups have allowed us to determine general regularities of organism’s reaction to a severe burn trauma and to show changes in the lipid metabolism caused by age and functional state of systems and organs. Thus, in early-age children, adaptation reactions break under the conditions of long stress. In elder patients, compensatory abilities are more pronounced, which is indicative of the more adequate reaction to a severe burn injury.
Comparative analysis of cognitive functions in patients with episodic and chronic tension-type headache combined with psychovegetative syndrome and cerebrovascular disorders
Authors: Yegorova Ye. A. , Grigoriyeva V. N.
Published: April 2021

The purpose of the study was to compare cognitive functions in patients with episodic tension-type headache (EpTTH) and chronic tension-type headache (ChTTH).

EpTTH was diagnosed in 34 patients in which it combined with psychovegetative syndrome in 17 persons and with cerebrovascular disorders in 28 persons. ChTTH was diagnosed in 57patients; it was associated with psychovegetative syndrome in 17 of them and with cerebrovascular disorders in 40 of them.

Difference between EpTTH and ChTTH patients was revealed only for the patients with psychovegetative syndrome. Such difference was slight and refered the tests for attention switching.. Patients with cerebrovascular disorders demonstrated worse modally non-specific problems with memory and attention and higher anxiety and depression levels that patients with psychovegetative syndrome.

Results suggest the different mechanisms of tension headache prolongation in the patients with psychovegetative syndrome and cerebrovascular disorders. The chronic tension headache itself doesn’t worse the cognitive functions while general causes exist which influence neuropsychological decline as well as tension headache stability.
Therapy of epilepsy: analysis of pseudo-drug resistance
Authors: Yegorova N. V. , Maslova N. N.
Published: April 2021

A clinical pharmacological study (67 patients) was made to analyses of pseudoresistance reasons. During standard AED dose treatment, remission was achieved in 80% of the patients.
Clinical-epidemiological aspects of Kazan Center for Extrapyramidal Pathology
Authors: Zalyalova Z. A. , Bogdanov E. I. , Latypova G. R. , Yakovleva L. A.
Published: April 2021

Pathology of extrapyramidal nervous system (EP) is one of the most complex sections of clinical neurology. Specificity of EP disorders accounts for the necessity of specialized assistance to patients with parkinsonism, tremor, dystonias, tics and other hyperkinesias. The article gives an account of a 4-year experience of Center for Extrapyramidal pathology work, as well as its problems and achievements. A total of 1 738 patients with different motor disorders (total of 4 301 consultations) were examined in the center for the whole period of its existence. Scientific research work is carried on as well. On the basis of the experience it was found out that neurologists. Сome across considerable difficulties in making diagnosis and choice of extrapyramidal diseases treatment. We are planning to expand the use of modern techniques in diagnosis and treatment (including botulotoxin injections, deep brain stimulation), identification of epidemiology of some extrapyramidal disorders in Kazan city.
Constitutional and neurological determinants of dynamics of Pott's disease
Authors: Koveshnikova Ye. Yu. , Kuryachenko Yu. T.
Published: April 2021

The study of clinical and epidemiological particularities of the extrapulmonary tuberculosis (EPT) in Novosibirsk for period since 1992 on 2006 was performed. The constant trend of the musculoskeletal tuberculosis (MST) subgroup enlargement with spine involvement (Potts disease) was revealed. Prognostic value of body type and psycho typological particularities in estimation of time consolidation for involved vertebra was proved.
The oxidative stress is typical peculiarity by multiple sclerosis
Authors: Krotenko N. V. , Alifirova V. M. , Ivanova S. A.
Published: April 2021

The problem of pathogenesis of multiple sclerosis is of great importance in modern neurology and its solution allows to determine a pathogenetic approach to treatment of this severe disease. Complex clinical-biochemical investigation has been conducted in 79 patients with multiple sclerosis and 75 mentally and physically healthy persons. Parameters of intensification of lipid peroxidation and indices of the state of enzymatic and non-enzymatic patterns in antioxidant defense system in different clinical forms and at different stages of MS course have been analyzed. The data obtained confirm the presence of oxidant stress in the development of pathological process in MS.
Clinical peculiarities in the course of cardioembolic stroke in patients with cardiac pathology
Authors: Kuryachenko Yu. T. , Oleksyuk N. V.
Published: April 2021

Revealing the particularities of the ischemic stroke course in patients with different types of cardiac pathology, with disturbances of the rhythm first of all, can play the certain role in forecast and tactic of the treatment of this disease. Analysis of the clinical particularities of the cardioembolic stroke course, depending on infarction localizations and type accompanying heart pathology was made. Examination of 61 patients, with determination degree of stroke gravity using American Scale (NIH-NINDS) on 1-st, 3-d and 10-th day of the disease was performed. The positive correlation was revealed between patients age and cardioembolic stroke frequency, cardiac rhythm disturbances and primary localization of the ischemia in pool of the left middle cerebral artery. The permanent form of the precordial twinkling is the most disadvantage prognosis factor and associated with forming the more severe neurological deficit.
Correlation between vegetative dysfunction and cognitive impairment in patients with chronic ischemia of the brain
Authors: Mokina T. V. , Doschannikov D. A. , Аntipenko Ye. A. , Gustov A. V.
Published: April 2021

The purpose of present research is to estimate the correlation between vegetative dysfunction and cognitive impairment in patients with chronic ischemia of the brain. We supervised 112 patients with chronic ischemia of the brain. To determine cognitive impairment we used Mini Mental State Examination scale. To determine vegetative dysfunction we used A.M.Vayne's questionnaire. Also heart rate variability (HRV) examination was carried out. All the patients were divided into 2 groups depending on expressiveness of cognitive impairment: light and moderate cognitive impairment. The expressed vegetative dysfunction was revealed according to A.M.Vejna's questionnaire and according to HRV in patients with moderate cognitive impairment. In patients with chronic ischemia of the brain with moderate cognitive impairment revealed shift of vegetative balance aside prevalence of hyperactivity of sympathetic adrenal system that is adverse the factor in progressing a chronic ischemia of a brain.
Type A botulinum toxin (disport) in treatment of chronic forms of primary headache
Authors: Napriyenko M. V. , Oknin V. Yu. , Sazonova A. G. , Kudayeva L. M.
Published: April 2021

The aim of this investigation is to study the effect of BTA on the cerebral blood flow in patients with chronic daily headache. The analysis of Doppler ultrasonography and transcranial Dopplergraphy findings has shown the following: after the treatment 34% of the patients had no extravasal effect and in 66% of the patients it became moderate and after the treatment normal venous outflow was found in 58% of the patients . The results of the pilot study demonstrate the effect of BT-A injection on the cerebral blood flow by means of optimizing both the arterial blood flow and the venous outflow from the cavity of the skull.
Capabilities of the modernized technique of one-photon emission computer tomography of brain with 99mTc-MIBI in determination of the degree of malignancy of glial tumors
Authors: Dekan V. S. , Martynov B. V. , Trufanov G. Ye. , Svistov D. V.
Published: April 2021

99mTc-MIBI Brain SPECT results of 79 patients with glial brain tumors are presented in the issue. The new technique of brain SPECT with 99mTc-MIBI was discovered and its oppotunities in characterization of tumor grade is shown in his study.
Modern problems of diagnostics and surgical treatment of patients with multifocal injuries of a brain with polytrauma
Authors: Bumay A. O.
Published: April 2021

Severe head traumas in combination with multiple injuries of polytrauma are important factors for the prognosis of morbidity and mortality in patients. The prognosis mainly depends on the presence of primary mechanic brain injury and the development of secondary brain damage. In patients with traumatic brain injury, intracranial hypertension against multifocal injuries secondary to cerebral edema is a major problem. We have made literature review.
Surgical treatment of cranial orbit tumors
Authors: Zakondyrin D. Ye. , Ryabukha N. P. , Bersnev V. P.
Published: April 2021

The pathology of cranioorbital region draws attention of surgeons of various specialities because of close and difficult anatomic mutual relation of a cavity of a skull, an orbit and additional sinuses of a nose. To various pathological processes, in particular to tumours of this localization, were long since developed extracranial and transcranial approaches depending on primary diffusion of pathological processes. The group of extracranial approaches is especially numerous and includes both transorbital, and approaches through additional sinuses of a nose. Division of transcranial approaches is based on presence or absence of necessity of mobilisation in the course of approach supraorbital edge.
Successful treatment of malignant meningioma at late period of pregnancy
Authors: Olyushin V. Ye. , Martynova M. V.
Published: April 2021

We represent cases of women which presented with meningiomas associated with pregnancy. This tumor associated with pregnancy not often but if it occurs, meningioma is having fast growth. We describe the case of 43-years-old woman with huge malignant meningioma and a hemorrhage in it which under-went craniotomy during the 38th week of pregnancy because of sharp deterioration. The surgical procedure and postoperative period were relatively easy. Besides we have made literature review.
Luciferase activity changes during the acute period of tick-borne mixed infection in children
Authors: Pinevich O. S. , Poponnikova T. V. , Sukhikh A. S. , Zinchuk S. F. , Galiyeva G. Yu.
Published: April 2021

The research of clinical characteristics of different tick mixed infections etiological variants in children — tick-borne encephalitis, ixodid tick-borne borreliosis, granulocytic anaplasmosis and monocytic ehrlichiosis in human in Kemerovo region showed a possibility of feverish meningeal and meningoencephalitic forms of disease. The comparative analysis of mono- and mixed infections according to the principal clinical criteria showed the predominance of non-specific symptoms and more severe clinical course in mixed etiology, the pathognomonic for ixodid tick-borne borreliosis symptoms are rare. One of the main causes of severity of state and sequences of the disease is the autotoxemia syndrome. The use of the luciferase method in the diagnosing of the autotoxemia syndrome in tick mixed infections allows to predict the development of severe forms of the disease.
Methods and current results of spinal tumor surgery
Authors: Polyakov Yu. Yu. , Olyushin V. Ye. , Gulyayev D. A. , Tastanbekov M. M.
Published: April 2021

Spinal tumor surgery is one of the hardest neurosurgical branch, which requires microsurgical equipment and intraoperative monitoring. Spinal tumor diagnostics can be very difficult because of clinical signs same for other disease in case of acute clinical manifestation. Severity of disease is burdened with concomitant somatic symptomatology. According to histology, dissemination and vertebral lesion, each definite case should be examined individually and in complex. Only the surgical method is not enough for the decision of spinal tumor problem. It is obvious, than problem of pathogenesis, diagnostics and operative treatment of spinal cord tumors is task of current importance at present stage of neurological and neurosurgical development. This article presents surgery results for patients treated at Russian Neurosurgical Institute named after prof. A.L.Polenov, neurooncology department in period of time 1999—2007.
Efficacy assessment of treatment of the posttraumatic autonomic dysfunction with use of the method computer finger tremorography
Authors: Prokopenko S. V. , Shanina Ye. G. , Shanin Ye. V. , Prokopenko V. S.
Published: April 2021

Clinical examination of an efficacy assessment of treatment of patients in the early reduction term after mild closed craniocerebral trauma (MCCCT) is carried out. In inspection it is included 27 patients after MCCCT with manifestations of an autonomic dysfunction syndrome. The diagnosis was established on the clinical examination, paraclinic inspection, research of the vegetative status, and also an author's method computer finger tremorography. Course treatment was carried out by a drug neurometabolic activity (propionate dihydrate). Authentic efficacy of treatment of an autonomic dysfunction manifestations in patients in the early reduction term after MCCCT. The method computer finger tremorography reliably displays a state of normalization of vegetative functions.
The experience of used Korteksin preparation in complex treatment disease vein Gilles de la Tourette in children
Authors: Solomin S. A. , Shmidt I. R. , Galantyuk I. G.
Published: April 2021

The disease Gilles de la Tourette (generalized teak, disease or syndrome Tourette and others) — respecting rare organic disease of the encephalon, revealing presence varied hyperkinesias and vocals of the breaches.

Under observation was found 26 children at age with 7 before 14 years with different degree evidence motor and vocals frustration at period with 2002 on 2007. Of them boys 21 (80,7%), girls 5 (19,2%). All children got the traditional treatment by used our department with addition of Korteksin preparation in medical drug blockade in points Vg 15, 16. Korteksin in complex treatment disease Gilles de la Tourette promotes more quick and more long removal motor and vocals frustration.
Meeting the demands of climate change: Australian consumer acceptance and sensory profiling of red wines produced from non-traditional red grape varieties
Authors: Mezei Laura V. , Johnson Trent E. , Goodman Steven , Collins Cassandra , Bastian Susan E. P.
Published: April 2021

To endure the challenge of climate change, the Australian wine industry could adopt new wine grape varieties more tolerant of these pending conditions. The aims of this study were to (i) generate sensory profiles and (ii) gain knowledge about Australian wine consumers’ liking of Australian and international wines made from selected drought-resistant, red wine grape varieties not traditionally grown in Australia but better suited for a changing Australian climate. A Rate-All-That-Apply (RATA) sensory panel (n = 43) profiled 24 commercial red wines made from 9 purportedly drought-tolerant red grape varieties, plus a single example of an Australian Cabernet-Sauvignon, Grenache and Shiraz wine. A subset of 10 wines was subjected to preference trials with Australian red wine consumers (n = 113) and underwent basic chemical composition measures. Consumers liked all 10 wines, scoring them greater than 5.7 on a 9-point Likert scale. The Fine Wine Instrument (FWI) identified 3 consumer segments (Wine Enthusiasts (WE); Aspirants (ASP) and No Frills (NF)). WE liked the 2 Touriga Nacional and Nero d’Avola wines significantly more than the NF consumers and the Graciano significantly more than the ASP. Correlation tests determined that the WE segment liked wines with aromas of vanilla, sweet taste, jammy, confectionary, vanilla and woody flavours and a non-fruit after taste, and the attributes responsible for the ASP segment's liking of the wines were red colour, jammy and toasty/smoky aromas, jammy and savoury flavours and alcohol mouthfeel and non-fruity aftertaste. NF consumers liked wines with aromas of vanilla, confectionary, jammy and red fruit flavours; smooth mouthfeel and a fruity aftertaste, but disliked wines displaying aromas of cooked vegetables and savoury, bitter taste, flavours of cooked vegetables, forest floor, green pepper and herbaceous, and rough mouthfeel. WE liked wines reminiscent of Cabernet-Sauvignon, Grenache and Shiraz while the ASP and NF consumers had preferences leaning towards wines similar in style to a Shiraz and Grenache, respectively. These findings indicate to wine producers the potential of these new wines in the current Australian market and the possibility that increasing future cultivation of these varieties as a response to climate change might lead to a more sustainable wine industry in the future.
Student Annotations of Published Data as a Collaboration between an Online Laboratory Course and the C. elegans Database, WormBase
Authors: Grove Christian , Ismail Samiya , Hulsey-Vincent Heino , Dahlberg Caroline
Published: April 2021

Course-based Undergraduate Research Experiences (CUREs) provide the same benefits as individual, mentored faculty research while expanding the availability of research opportunities. One important aspect of CUREs is student’s engagement in collaboration. We developed a partnership with the Caenorhabditis elegans (C. elegans) database, WormBase, in which students submitted annotations of published manuscripts to the website. This activity provided students with a collaborative research activity that benefitted the greater scientific community and enhanced students’ understanding of molecular genetics during the COVID-19 pandemic. WormBase relies on community annotators to read published articles and input phenotypic data. Students submitted a total of nine annotations directly to WormBase, which were curated by WormBase to ensure correctness and to reduce overlap from redundant annotations. Due to the stress on students during this time of crisis, qualitative data were collected in lieu of quantitative pre-post analyses. Students described their learning experiences in terms of interactions with the scientific community and the “real world”, content knowledge and competencies, and changes in perspectives and use of resources. Students also reported that this activity was helpful in their understanding of critical molecular genetics concepts. Most students reported on cognitive processes that represent mid-level Bloom’s categories. The shift to online learning during the COVID-19 pandemic created an immediate need for meaningful, collaborative experiences in CUREs. By partnering with WormBase, students gained insight into the scientific community and contributed as community members. We describe possible modifications for future courses, potential expansion of the WormBase collaboration, and future directions for quantitative analysis.
Repetition is Important to Students and Their Understanding During Laboratory Courses that Include Research
Authors: Wiggins Benjamin , Lily Leah , Sefi-Cyr Haley , Dahlberg Caroline
Published: April 2021

Course-based undergraduate research experiences (CUREs) provide students with opportunities for the same gains that apprenticed research with faculty members offer. As their popularity increases, it is important that critical elements of CUREs are supported by thoughtful design. Student experiences in CUREs can provide important insights into why CUREs are so effective. We present evidence from students who participated in CUREs at the introductory, intermediate, and advanced levels, as well as from graduate teaching assistants for an introductory lab course that included a CURE. Students and teaching assistants describe repetition as a valuable element in CUREs and other laboratory experiences. We used student work and open-ended interviews to identify which of five previously described elements of CUREs students found important. Because repetition was particularly salient, we characterized how students described repetition as they experienced it in courses that contained full-length or “micro”-CUREs. In prompted interviews, students described how repetition in CUREs provided cognitive (learning concepts) and practical (learning technical skills) value. Recent graduates who had participated in CUREs at each level of their Biology education were particularly aware that they placed value in repetition and acknowledged it as motivational in their own learning. Many students described repetition in metacognitive terms, which also suggests that as students advance through laboratory and CURE curricula, their understanding of how repetition supports their learning becomes more sophisticated. Finally, we integrated student descriptions to suggest ways in which repetition can be designed into CUREs or other laboratory courses to support scientific learning and enhance students’ sense of scientific identity.
Strategies for Improving the Sustainability of Data Centers via Energy Mix, Energy Conservation, and Circular Energy
Authors: Manganelli Matteo , Soldati Alessandro , Martirano Luigi , Ramakrishna Seeram
Published: April 2021

Information and communication technologies (ICT) are increasingly permeating our daily life and we ever more commit our data to the cloud. Events like the COVID-19 pandemic put an exceptional burden upon ICT infrastructures. This involves increasing implementation and use of data centers, which increased energy use and environmental impact. The scope of this work is to take stock on data center impact, opportunities, and assessment. First, we estimate impact entity. Then, we review strategies for efficiency and energy conservation in data centers. Energy use pertain to power distribution, IT-equipment, and non-IT equipment (e.g. cooling): Existing and prospected strategies and initiatives in these sectors are identified. Among key elements are innovative cooling techniques, natural resources, automation, low-power electronics, and equipment with extended thermal limits. Research perspectives are identified and estimates of improvement opportunities are presented. Finally, we present an overview on existing metrics, regulatory framework, and bodies concerned.