bluuebunny/crossref_metadata_2025 huggingface dataset:
Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial
Authors: Xu Rui-Hua , Shen Lin , Wang Ke-Ming , Wu Gang , Shi Chun-Mei , Ding Ke-Feng , Lin Li-Zhu , Wang Jin-Wan , Xiong Jian-Ping , Wu Chang-Ping , Li Jin , Liu Yun-Peng , Wang Dong , Ba Yi , Feng Jue-Ping , Bai Yu-Xian , Bi Jing-Wang , Ma Li-Wen , Lei Jian , Yang Qing , Yu Hao
Published: December 2017

Background

Metastatic colorectal cancer (mCRC) patients with progressive disease after all available standard therapies need new medication for further treatment. Famitinib is a small-molecule multikinase inhibitor, with promising anticancer activities. This multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial was designed to evaluate the safety and efficacy of famitinib in mCRC.

Methods

Famitinib or placebo was administered orally once daily. The primary endpoint was progression-free survival (PFS). Secondary endpoints included objective response rate (ORR), disease control rate (DCR), overall survival (OS), quality-of-life (QoL), and safety.

Results

Between July 18, 2012 and Jan 22, 2014, a total of 167 patients were screened, and 154 patients were randomized in a 2:1 ratio to receive either famitinib (n = 99) or placebo (n = 55). The median PFS was 2.8 and 1.5 months in the famitinib and placebo groups (hazard ratio = 0.60, 95% confidence interval = 0.41–0.86, P = 0.004). The DCR was 59.8% and 31.4% (P = 0.002) and the ORR was 2.2% and 0.0% (P = 0.540) in the famitinib and placebo groups, respectively. The most frequent grade 3–4 adverse events were hypertension (11.1%), hand-foot syndrome (10.1%), thrombocytopenia (10.1%), and neutropenia (9.1%). Serious adverse events occurred in 11 (11.1%) patients in the famitinib group and 5 (9.1%) in the placebo group (P = 0.788). The median OS of the famitinib and placebo groups was 7.4 and 7.2 months (P = 0.657).

Conclusion

Famitinib prolonged PFS in refractory mCRC patients with acceptable tolerability.

Trial registration This study was registered on ClinicalTrials.gov (NCT01762293) and was orally presented in the 2015 ASCO-Gastrointestinal Symposium
Superresolution imaging using resonant multiples
Authors: Guo Bowen , Schuster Gerard T.
Published: December 2017

A resonant multiple is defined as a multiple reflection that revisits the same subsurface location along coincident reflection raypaths. We have found that resonant first-order multiples can be migrated with either Kirchhoff or wave-equation migration methods to give images with approximately twice the spatial resolution compared with poststack primary-reflection images. We have developed a moveout-correction stacking method to enhance the signal-to-noise ratios of the resonant multiples for superresolution migration. The effectiveness of this procedure is validated by synthetic and field data tests.
Intersystem Crossing Mechanisms in the Room Temperature Phosphorescence of Crystalline Organic Compounds
Authors: Yuasa Hideya , Kuno Shinichi
Published: December 2017

Reports on the room temperature phosphorescence of metal-free organic crystals have been surging in the past few years. Together with interests in the rare phenomenon, these compounds have attracted attention for such potential applications as bio-imaging probes, oxygen sensors, and organic light-emitting diodes. For common organic compounds, phosphorescence is the emission from a triplet excited state, which is usually produced from a singlet excited state through intersystem crossing, a forbidden spin-flip of an electron. The mechanism of the forbidden process is the key to understanding such rare phenomenon and designing new phosphorescence materials. In this account, we make commentaries on the main intersystem crossing mechanisms proposed to date of the room temperature phosphorescence of heavy-atom-free, crystalline organic compounds, focusing on our own findings.
Overuse of CT and MRI in paediatric emergency departments
Authors: Ohana Orly , Soffer Shelly , Zimlichman Eyal , Klang Eyal
Published: December 2017

The aim of this review is to survey CT and MRI overuse in the paediatric emergency department (ED) population. CT is one of the most important modalities employed in the ED. Not surprisingly, its high accuracy, rapid acquisition and availability have resulted in overuse. An obvious limitation of CT is ionizing radiation; in addition there are economic implications to overuse. Studies from the last two decades have shown increase in paediatric ED CT utilization in the first decade, reaching a plateau forming around 2008, followed by a decrease in the last decade. This decrease occurred in conjunction with campaigns raising awareness to the risks of radiation exposure. Although a trend of decrease in overuse have been observed, great variability has been shown across different facilities, as well as among physicians, with more pronounced overuse in non-teaching and non-children dedicated EDs. The leading types of paediatric ED CTs are head and abdominal scans. Decision rules, such as PECARN for head injury and the Alvarado score for abdominal pain, as well as using alternative imaging modalities, have been shown to reduce CT overuse in these two categories. MRI has the obvious benefit of avoiding radiation exposure, but the disadvantages of higher costs, less availability and less tolerability in younger children. Although anecdotally paediatric ED MRI usage has increased in recent years, only scarce reports have been published. In our opinion, there is need to conduct up-to-date studies covering paediatric CT and MRI overuse trends, usage variability and adherence to clinical protocols.
Sleep apnea and its role in transportation safety
Authors: Bonsignore Maria
Published: December 2017

Obstructive sleep apnea (OSA) is a main cause of excessive daytime sleepiness and increases the risk for driving accidents, which can be normalized by treatment with continuous positive airway pressure ventilation. Since it is estimated that OSA is not diagnosed in about 80% of cases, recognition of patients at risk for driving accidents is a problem from both medical and societal points of view. Strategies to screen and identify subjects at high risk for driving accidents are under study in order to improve safety on the road, especially for commercial drivers, who show a high prevalence of OSA.
Collaboration between a human group and artificial intelligence can improve prediction of multiple sclerosis course: a proof-of-principle study
Authors: Tacchella Andrea , Romano Silvia , Ferraldeschi Michela , Salvetti Marco , Zaccaria Andrea , Crisanti Andrea , Grassi Francesca
Published: December 2017

Background:Multiple sclerosis has an extremely variable natural course. In most patients, disease starts with a relapsing-remitting (RR) phase, which proceeds to a secondary progressive (SP) form. The duration of the RR phase is hard to predict, and to date predictions on the rate of disease progression remain suboptimal. This limits the opportunity to tailor therapy on an individual patient's prognosis, in spite of the choice of several therapeutic options.

Approaches to improve clinical decisions, such as collective intelligence of human groups and machine learning algorithms are widely investigated.

Methods:Medical students and a machine learning algorithm predicted the course of disease on the basis of randomly chosen clinical records of patients that attended at the Multiple Sclerosis service of Sant'Andrea hospital in Rome.

Results:A significant improvement of predictive ability was obtained when predictions were combined with a weight that depends on the consistence of human (or algorithm) forecasts on a given clinical record.

Conclusions:In this work we present proof-of-principle that human-machine hybrid predictions yield better prognoses than machine learning algorithms or groups of humans alone. To strengthen this preliminary result, we propose a crowdsourcing initiative to collect prognoses by physicians on an expanded set of patients.
Scale up of a Plasmodium falciparum elimination program and surveillance system in Kayin State, Myanmar
Authors: Parker Daniel M. , Landier Jordi , Thu Aung Myint , Lwin Khin Maung , Delmas Gilles , Nosten François H. ,   The Malaria Elimination Task Force Group
Published: December 2017

Background: Myanmar has one of the largest malaria burdens in the Greater Mekong Subregion (GMS). Throughout the GMS, Plasmodium falciparum parasites are increasingly resistant to artemisinin combination therapies. Given that there are no current alternative treatment therapies, one proposed solution to the threat of untreatable P. falciparum malaria is to eliminate the parasite from the region. Several small-scale elimination projects have been piloted in the GMS, including along the Myanmar-Thailand border. Following the success of the pilot elimination project along the Myanmar-Thailand border, there was a scale up to a broad area of Eastern Kayin State, Myanmar. Here we describe the establishment of the scale up elimination project in Easter Kayin State.

Methods: The scale up relied on geographic reconnaissance and a geographic information system, community engagement, generalized access to community-based early diagnosis and treatment, near real-time epidemiological surveillance, cross sectional malaria prevalence surveys and targeted mass drug administration in villages with high prevalence of P. falciparum malaria. Molecular markers of drug resistance were also monitored in individuals with symptomatic and asymptomatic infections.

Discussion: This protocol illustrates the establishment of an elimination project and operational research in a remote, rural area encompassing several armed groups, multiple political organizations and a near-absent health care infrastructure. The establishment of the project relied on a strong rapport with the target community, on-the-ground knowledge (through geographic surveys and community engagement), rapid decision making and an approach that was flexible enough to quickly adapt to a complex landscape. The elimination project is ongoing, now over three years in operation, and assessment of the impact of this operational research will follow. This project has relevance not only for other malaria elimination projects but also for operational research aimed at eliminating other diseases.
Tests of exponentiality against some parametric over/under-dispersed life time models
Authors: Mian Rajibul , Paul Sudhir
Published: December 2017

We develop tests of goodness of fit of the exponential model against some over/under dispersion family of distributions. In particular, we develop 3 score test statistics and 3 likelihood ratio statistics. These are (S1, L1), (S2, L2), and (S3, L3) based on a general over-dispersed family of distributions, two specic over/under dispersed exponential models, namely, the gamma and the Weibull distributions, respectively. A simulation study shows that the statistics S3 and L3 have best overall performance, in terms of both, level and power. However, the statistic L3 can be liberal in some instances and it needs the maximum likelihood estimates of the parameters of the Weibull distribution as opposed to the statistic S3 which is very simple to use. So, our recommendation is to use the statistic S3 to test the fit of an exponential distribution over any over/under-dispersed exponential distribution.
Problems of estimation of production efficiency and use of pellets
Authors: Ванин Максим , Vanin Maksim
Published: December 2017

One of the directions of development of enterprises of the timber processing complex today is their modernization, which includes a complete replacement of obsolete equipment for modern high-performance, automated analogues. Obviously, at the same time, the capacity of production, the volume of output, is substantially increased, which leads to an increase in production waste. To solve the problem of their rational use, we propose to introduce a technology for the production of biofuel (fuel pellets), based on the process of crushed waste products pressing. The proposed project includes construction of a workshop for production of pellets with a capacity of 50 thousand tons per year, their packaging and storage. The description of the technological process with the identification of a number of its stages is given, the economic justification of the investment project efficiency is fulfilled, the project implementation schedule is developed, the main performance indicators are calculated and the possible risks associated with the project implementation are identified. The presented calculations testify to sufficient financial strength of the project and its financial solvency. There are two options for using the produced products. The first is generally accepted, based on the export orientation of pellets and their supply to the ever growing European market. The second one is an alternative one, envisaging construction or modernization of obsolete boiler houses and their transfer to cheaper, biologically clean wood fuel. The proposed alternative approach is aimed at solving existing problems in the field of ecology and the energy industry. The use of pellets will significantly reduce the environmental impact caused by coal or fuel oil as a fuel, and can also solve the problem of providing lower-cost energy to remote enterprises and residential areas.
Theoretical concepts of multi-purpose, rational continuous use of forests in Russia and abroad
Authors: Лихацкий Ю. , Lihackiy Yu. , Черных Александр , Chernykh Aleksandr , Харин Сергей , Kharin Sergei
Published: December 2017

Forests take diverse part in the life of human society. To prevent their depletion and disappearance, the organization of forestry on the principle of continuous, non-depleting and multi-purpose use of forests is necessary. The article analyses the theoretical concepts of multi-purpose, rational use of forests in Russia and abroad. Special place is given to the conceptual foundations of multi-purpose, rational, continuous use of European forests. The essence of the concept and limitations for different regions of Europe is given. Based on the content analysis, it was concluded that a sustainable approach to forest management implies the use of innovative strategies for conserving biodiversity, balancing forest use for various purposes and healthy ecosystem maintenance. Analysis of the concept of sustainability of forest management in Russia and abroad, in terms of theoretical concepts, allowed us to define fundamental principles.
The method of determining the silvicultural and inventory indices of urban spaces with the use of the equations of communication
Authors: Ковязин Василий , Kovyazin Vasiliy , Нгуен Тхи , Nguen Thi
Published: December 2017

The purpose of our research was to study the species diversity of trees and shrubs in the memorial Park across three centuries after its formation. Such research we carried out for the first time. In addition, we conducted measurements of forest inventory indices of the studied tree species. The calculated equation of the relationship of tree age with a height and diameter that can be measured. The mathematical models should be used to determine the age of trees, as the drill age is not recommended to use for traditional purposes in the memorial parks. The tightness of the obtained relations inventory indices in the form of a parabola is quite high. The coefficient of determination is 0.82 to 0.99, depending on the type of wood.
Visual sorting of sawn timber based on the calculation method for determining the volume of blanks
Authors: Кривощёков Никита , Krivoschekov Nikita , Рыкунин Станислав , Rykunin Stanislav , Куликова Надежда , Kulikova Nadezhda
Published: December 2017

The presented research is devoted to the definition of the fragmentation of the sorting of lumber and the boundaries of sorting groups according to the value of the volume output of the primary harvesting, based on the calculation method for determining the volume output of harvesting for the furniture board. The article provides a brief overview of research on the evaluation of timber quality. The scheme for assessing the quality of lumber wood is given. The volumetric output and output parameters of cut modeling of the 1st and 2nd quality groups of sawn timber for blanks for the production of the furniture board of A grade are presented. The technique for determining the boundaries of sorting groups using the volumetric output of the main billet based on the calculated method for determining the volume yield of blanks for a furniture board. Visual sorting on the main work piece increases the volume output of solid blanks of the 1st quality group by 8.61% and the volume output of short blanks of the 2nd quality group by 8.54% compared to the calculated method. Sorting sawn timber according to the proposed indicator simplifies this process, and also allows achieving a functional dependence approximate to 1 between the quality of sawn timber and the quality of blanks, except for errors of quality controllers or operators that perform sorting.
Automation of the data processing procedure on the basis of a strong semantic connection
Authors: Лапшина Марина , Lapshina Marina , Юдина Надежда , Yudina Nadezhda , Богомолова Т. , Bogomolova T. , Бойкова А. , Boykova A.
Published: December 2017

One of the defining tasks in automating the processing of current information obtained in the process of object research is the possibility of assigning it to specific objects located in the database (DB) of the information system. Such a task can be represented as a task of identifying the objects of analysis (monitoring) on current data. Initial information about a particular facility during the research can come from different sources and be incomplete and inaccurate. Due to identification, received data for each object are accumulated in the database for further automated analysis. But in a number of cases, the current information contains not specific names of the research objects of interest, but only some signs of their functioning: location, operating time, numerical characteristics of objects, etc. In such conditions, the identification of objects can occur on the basis of similarity of semantic features contained in the current information and attributes which have been already accumulated by the objects of research in the database. A distinctive feature of the subject area in which the analysis of objects is made is its variability; therefore, with the passage of time, the attributes serving to identify the objects may change. The addition of new features will result in a change in application software and will require the involvement of developers, which leads to additional time costs and decrease in the speed of procedure for identifying objects. This reason leads to the need to create a new approach to the automation of object monitoring, based on such requirements as high quality of the decisions made and ability to quickly change the logic of identification in the process of the system. The paper proposes the possibility of using predicate logic formulas, with the aim of making new information in the database more quickly and assigning it to a specific object, which makes it possible to develop the fastest solution.
The development of labor potential
Authors: Асалиев Асали , Asaliev Asali , Мирзабалаева Фарида , Mirzabalaeva Farida , Алиева Патимат , Alieva Patimat
Published: December 2017

In the tutorial dedicated to the development of labor potential are considered problems of formation and use of labor potential at various levels (from the individual worker to society as a whole), the realization of the potential of certain population groups (such as women, youth, the elderly and the disabled), the influence of individual components on the development of labor potential (education, health, employment), barriers to the development of labor potential (emotional burnout, mobbing, discrimination); Russian and international experience of development of labor potential.
Upper bounds on Q-spectral radius of book-free and/or $K_{s,t}$-free graphs
Authors: Kong Qi , Wang Ligong
Published: December 2017

In this paper, we prove two results about the signless Laplacian spectral radius $q(G)$ of a graph $G$ of order $n$ with maximum degree $\Delta$. Let $B_{n}=K_{2}+\overline{K_{n}}$ denote a book, i.e., the graph $B_{n}$ consists of $n$ triangles sharing an edge. The results are the following: (1) Let $1< k\leq l< \Delta < n$ and $G$ be a connected \{$B_{k+1},K_{2,l+1}$\}-free graph of order $n$ with maximum degree $\Delta$. Then $$\displaystyle q(G)\leq \frac{1}{4}[3\Delta+k-2l+1+\sqrt{(3\Delta+k-2l+1)^{2}+16l(\Delta+n-1)}$$ with equality if and only if $G$ is a strongly regular graph with parameters ($\Delta$, $k$, $l$). (2) Let $s\geq t\geq 3$, and let $G$ be a connected $K_{s,t}$-free graph of order $n$ $(n\geq s+t)$. Then $$q(G)\leq n+(s-t+1)^{1/t}n^{1-1/t}+(t-1)(n-1)^{1-3/t}+t-3.$$
Effect of theRehydration Cycles on the Quality Changes of Retorted Sea Cucumber (StichopusJaponicus) During Storage
Authors: Kim Yoon Sung , Yoon Won Byong
Published: December 2017

Quality changes of dried sea cucumber (StichopusJaponicus) after applying a cyclic rehydration and retorting process were investigated during 4 weeks of storage. The length, volume, and weight of dried sea cucumber increased significantly as the number of rehydration cycles increased. Sea cucumber (SC) was bottled in the glass jar and a retort thermal process (121.1°C, 0.15 MPa) was applied. The total thermal processing time (TTT) was 24 min based on the temperature at the cold point. The size and texture of retorted SC were significantly changed until the first week of storage. However, regardless of the number of rehydration cycles, the size and texture of samples at different rehydration cycles showed no significant difference during the whole storage. The length, volume, weight, rehydration ratio (RR), hardness, and chewiness at the maximum degree of swelling during rehydration of dried SC were estimated as 100.86 mm, 38.62 mL, 41.05 g, 6.39 of RR, 249.19 gf, and 4.05 mJ, respectively.
Back to the dance itself: In three acts
Authors: Fraleigh Sondra
Published: December 2017

Back to the things themselves I cry, or else philosophy will die. My cry is an ontological one, asking, as constitutive phenomenology does, ‘what is this thing (called dance) made of’? How do we live consciousness in dance? Let me count the ways. In its aim to rescue consciousness and experience as key concerns of philosophy, phenomenology is no stranger to conceptual analysis, but not as a science. At the same time, definitional work is key in the performance of phenomenology, with the experiential study of things (anything) being basic. How does meaning arise in dance, for instance, and why is intentionality important? What is the difference between movement and action? What are the materials of dance? Or shall we assume that dance is wholly immaterial? These are fundamental questions of philosophical enquiry in phenomenology that interest me deeply in this essay, even as I have engaged phenomenology for 49 years and am still learning. Phenomenology is not a philosophy of closure, and in this spirit, is being developed on several fronts in dance, as recent Intellect journals show, Dance Movement and Spiritualities, 2:2, and Dance and Somatic Practices, 8:2. I hope to contribute further in this endeavour. When I first encountered non-dual discourses of ‘the lived body’ and ‘pre-objective world’, I realized what a goldmine this represented for bodily oriented studies. I barely scratch the surface here, or in the wider scope of Dance and the Lived Body (1987) and Dancing Identity: Metaphysics in Motion (2004). Since Edmund Husserl’s initiation of phenomenology, questions regarding normative understandings of body, self, materiality and subjectivity continue. Consciousness is shaped, or we could say ‘intended’, in countless ways. This has consequences for understanding somatic movement arts as a field of study, as we take up.
Book Reviews
Authors: Batson Glenna , Stancliffe Rebecca
Published: December 2017

Mindful Movement: The Evolution of the Somatic Arts and Conscious Action, Martha Eddy (2016) Chicago, IL, USA: Intellect/University of Chicago Press, 367 pp., ISBN: 9781783205837, inclusive of index, h/bk, £40, $57

Zoi Dimitriou’s The Chapter House, Bonnie Bird Theatre, Trinity Laban, 12 April 2016
Introduction: Gaining insights into English as a contact language and its diffusion
Authors: Palacios Martínez Ignacio M. , Sánchez Fajardo José A.
Published: December 2017

The aims of this volume are twofold: to contribute to the study of English as a contact language and its various manifestations in World Englishes, and to explore the causes and effects of the influence and diffusion of English in several languages, with particular reference to Spanish.As Schreier and Hundt (2013: 1) have noted, the English language “has been contact derived from its very beginnings” and to this we can add that due to its rapid and far reaching extension, leading to its current role as a global contact language (Görlach, 2002), it continues to be closely connected to a wide range of communities of speakers and languages across the world. In fact, as Onysko (2016: 192) claims, "the notion of language contact emerges as a valid candidate for being a unifying characteristic of all Englishes".
Innovación en el diseño instruccional de cursos masivos abiertos con gamificación y REA para formar en sustentabilidad energética
Authors: Argueta Velázquez Martha Griselda , Ramírez Montoya María Soledad
Published: December 2017

Ante los retos que vive México en materia de sustentabilidad energética, principalmente en el sector eléctrico, surge el proyecto 266632 “Laboratorio Binacional para la Gestión Inteligente de la Sustentabilidad Energética y la Formación Tecnológica”. Una de las soluciones innovadoras que ofrece el Laboratorio Binacional para atender las necesidades de capacitación y entrenamiento en este tema, es ofertar un conjunto de MOOC (cursos masivos abiertos en línea). Esta investigación se enmarca dentro de este proyecto y tiene por objetivo comprender cómo funcionan los componentes de la innovación (atributos) en el diseño instruccional de un MOOC, que integra recursos educativos abiertos (REA) y gamificación, ofertado de enero a marzo de 2017. Son cuatro los componentes observados: la idea de lo nuevo, el fenómeno de cambio, la acción final y el proceso. El método empleado fue el método mixto, bajo un diseño explicativo secuencial. Como resultados, se encontró que el atributo de lo nuevo se presenta en un modelo pedagógico que integra gamificación, así como en la presentación del contenido a través de videos cortos de alto impacto, infografías y los REA. El fenómeno del cambio se comprende a través de la integración de un equipo multidisciplinario en torno al tema de energía. La acción final está presente en la colaboración, comunicación y compromiso de los especialistas. Mientras que el atributo del proceso evidenció que en la innovación abierta, colaborativa y multidisciplinar se presentan retos y potencialidades.
Archaeobotanical Approaches in the Study of Food Production in Remote Oceania
Authors: Levin Maureece Jacqueline
Published: December 2017

This short topical review discusses recent archaeobotanical approaches to understanding food production in Remote Oceania (eastern Melanesia, Micronesia, and Polynesia). The region presents some preservation and interpretative challenges, both due to the lack of cereal crops and the hot and humid climate that prevails through much of the area. Nevertheless, archaeobotanical analyses provide insight into topics such the transport of crops between islands and anthropogenic environmental change.
Identifying Turtle Shell Rattles in the Archaeological Record of the Southeastern United States
Authors: Gillreath-Brown Andrew , Peres Tanya M.
Published: December 2017

The construction of rattles from turtle (Testudines) shells is an important consideration when distinguishing between food and non-food uses of archaeological turtle remains. However, the identification of turtle shell rattles in prehistoric contexts can be quite challenging. Equifinality is a major problem for being able to distinguish rattles from food refuse, particularly when a carapace is not burnt or modified. In addition, diversity, abundance, and distribution of Chelonian taxa varies throughout the southeastern United States, creating differential access for indigenous groups. Thus, multiple lines of evidence are needed from archaeological, ethnographic, and ethnohistoric records to successfully argue for the production and use of turtle shell rattles in the prehistoric southeastern United States. In this article, we present examples of turtle shell rattles in the southeastern United States to highlight their function and use by indigenous groups, the construction process, and several common characteristics, or an object trait list, that can aid in the identification of fragmentary turtle shell rattle remains. Proper identification of turtle remains is important for interpreting faunal remains and may be of interest to indigenous groups claiming cultural items under the Native American Graves Protection and Repatriation Act (NAGPRA).
Marginal adaptation in proximal cavities restored with composites and other materials
Authors: Rodrigues Raphaela Farias , Senna Suellen Scarcelli , Soares Ana Flávia , Mondelli Rafael Lia , Francisconi Paulo Silveira , Borges Ana Flávia Sanches
Published: December 2017

Objective: To evaluate the marginal adaptation, in enamel (E) and dentin (D), of composite resin (CR) associated with flowable resin composite (flow), bulk fill flowable base (bulk) and resin modified glass ionomer cement (RMGIC) in slot cavities. Material and Methods: The study was conducted after approval (Protocol No. 21148413.4.0000.5417) from Ethics Committee. Forty extracted human molar teeth were randomly assigned in eight experimental groups: E-CR, E-BULK, E-FLOW, E-RMGIC, D-CR, D-BULK, D-FLOW, D-RMGIC. The occlusal surface was planned, two slot cavities with standard sizes (depth: 2.0 mm, height: 2.5 mm, width: 2.0 mm) were created on a machine for making cavities. The teeth were restored and after 24h subjected to 2000 cyclic loading and sectioned for analysis of marginal adaptation by scanning electron microscopy (SEM). The micrographs were analyzed with the Image J program to measure the size of marginal gaps. The data were transformed into percentages (%GAPS = LG ÷ LM  × 100) and analyzed by 2-way ANOVA followed by the post hoc Tukey test (?=0.05). Results: There was a significant difference between different treatments (p<0.01). The groups E-RMGIC (p=0.001) and D-RMGIC (p=0) had the highest percentage of marginal gap. Others groups showed similar percentage of marginal gap (p>0.05). Conclusions: It was concluded that restorations with flowable composite resin and bulk fill liners exhibit the same behavior, but the RMGIC liner increased marginal gap.Keywords: Composite resins; Dental marginal adaptation; Glass ionomer cements.
Comparative study of splinted and unsplinted implant-retained maxillary overdentures without palatal coverage: A literature review
Authors: Simões Ingrid ísis Nogueira , Spyrides Silvana Marques Miranda , Schanuel Fabiana Ribeiro da Silva , De Mello Elson Braga
Published: December 2017

The palatal coverage is considered as an auxiliary element in the distribution of tensile strains on implant maxillary total prosthesis (implant overdentures) bases, either implant-supported or retained. However, complaints in some patients due to palate and phonetic impairment are constant. The palatal coverage removal would allow the improvement of these issues as well as pharyngeal control, salivary flow and hygiene. Thus, this literature review proposed to analyze the survival rates of dental implants retaining an implant maxillary overdenture without palatal coverage in edentulous maxilla. The review was conducted in Medline database, via PubMed between 2000 to 2016 period, and limited to English language publications. The search strategy took the following key-words, referencing title and / or abstract: dental implants; maxilla; maxillary; overdenture; and palatal coverage. According the data, the rehabilitation of the maxillary edentulous with four implant-supported overdentures with bar attachments and implant-retained with ball attachments has shown great survival rates of dental implants, but there are a few studies reporting the survival rate of implant overdentures.  It was concluded that the prosthetic rehabilitation of total maxillary edentulous patients is viable through palateless implant overdentures when a minimum of four to six implants were used with careful planning and execution. KeywordsDental Implants; Maxilla; Overdenture and Palatal coverage.
Scaffold architecture for dental biomaterials: influence of process parameters on the structural morphology of chitosan electrospun fibers
Authors: De Souza Joyce Rodrigues , Sato Tabata Prado , Borges Alexandre Luiz Souto
Published: December 2017

Objective: The electrospinning is a widely adopted technique used to produce the polymeric fibers. The process depends on process parameters (voltage, flow rate and distance from capillary to the collector). The present study aimed to evaluate the influence of these parameters on chitosan fibers, a biopolymer used as scaffolds in dental and oral tissue engineering. Material and Methods: A solution of 7%(m/w) was prepared dissolving 0.7g of chitosan in 7 mL of trifluoroacetic acid (TFA) and 0.3mL of dichloromethane (DCM) (TFA/DCM - 70:30). After 12 hours, polymer solution (5 mL) was drawn into the syringe and pumped through needles of 0.4 mm internal diameter, at a rate of 0.8 mLh-1, different needle-tip-to-collector distances and voltages, for 10 min.  Electrospun fibers micrographies were obtained using the Scanning Electron Microscope for morphological analysis. Results: All voltages showed significant difference (p < 0.0001) between them. At 15kV fibers showed higher concentration of beads. At 10 and 12 cm of distance there was no statistical significance (p > 0.0001) but at 15 cm beads formation increased significantly (p < 0.0001). At 12 cm fibers showed lowest fibers diameter in comparison to 10 and 15 cm (p < 0.0001). There was no difference between 10 and 12 cm (p > 0.0001) but in comparison to 15 cm both distances presented significantly difference (p < 0.0001).  Conclusion: Thus, it can be concluded that morphology, in chitosan electrospun fibers, is influenced by the voltage and distance and this could describe the mohphological control of these structures. KeywordsChitosan; Fibers; Electrochemical.
Eje 3. Producciones cinematográficas contemporáneas: características y estrategias narrativas: Imágenes ausentes. Documental performativo, testigo y testimonio
Authors: Zylberman Lior
Published: December 2017

Numerosos son los autores que en las últimas décadas han pensado el lugar del cine como testigo, cómo éste ha trabajado para visualizar violaciones a derechos humanos, masacres y genocidios, al mismo tiempo que funciona como evidencia y promotor de conocimiento. Ejemplo paradigmático ha sido el archivo de imágenes alrededor del Holocausto, que desde 1945 hasta nuestros días no ha cesado de emplearse, de auscultarlo y estudiarlo. Ahora bien, ¿qué sucede cuando el cine documental, el cine de lo real, desea aproximarse a hechos como estos y cuenta con escasa o nula cantidad de imágenes para construir su relato? ¿A qué estrategias puede recurrir? La crisis de archivo lejos está de impedir la realización de obras sino que ha posibilitado y expandido las posibilidades creativas del cine documental a partir de estrategias que algunos autores han pensado bajo la idea de documental performativo.  En esa dirección, nos proponemos analizar los filmes Vals con Bashir (Ari Folman, 2008) y The Missing Picture (Rithy Panh, 2013) con el objetivo de estudiar sus estrategias de representación, lo que nos permitirá poner en tensión la relación entre cine, testimonio y testigo.
Eje 3. Producciones cinematográficas contemporáneas: características y estrategias narrativas: Imicraciones, mentira y ficción cinematográfica. Deconstruir a Pinocho, Desmontar a Gepetto
Authors: Rodríguez Herrero Virginia
Published: December 2017

A lo largo del tiempo y del espacio, la mentira ha sido rechazada, enviada al infierno en diversos idiomas y señalada, para bien de la humanidad. La importancia sociológica y antropológica de la mentira queda implícita en el hecho de que mentir es algo propio del ser humano y una pieza más de la estructura social. La mentira es falsedad, artificio y este se acerca mucho a la esencia de la ficción, de modo que cine y mentira tendrían, a priori, motivos para encontrarse. Pero tantas condenas ha recibido la mentira que el gran peso negativo que arrastra constituye el principal obstáculo a la hora de hablar de ella como un componente más de la ficción cinematográfica. Una vez desestimada la contaminación simbólica de la mentira, su construcción social en relación con el cine confluye en una común aceptación de que la capacidad creadora del ser humano está íntimamente vinculada con su humana posibilidad  de recurrir al juego de la manipulación, a la zentira, hasta el punto de que es posible considerar que el arte no pueda prescindir de ella. Efectivamente, la mentira es la herramienta base para crear ficciones, es el riesgo que hay que correr para poder construir nuevas realidades, es una vía legítima y honrada para transmitir verdad en un contexto creativo, es lo que el público espera y aquello en lo que está deseando creer.
¿Nuevas criadas y porteras en París?: reactivación de los campos sociales transnacionales de la emigración española tras la crisis económica
Authors: Oso Laura
Published: December 2017

Este artículo  analiza la migración de mujeres españolas a Francia tras la crisis económica de 2008, desde la perspectiva de la reactivación de los campos transnacionales, que se han ido construyendo históricamente entre ambos países. Muestra cómo los nichos ocupacionales generizados, que ocuparon las mujeres que migraron a París en los años 50-70 (bonnes à tout faire o criadas, empleadas de hogar, niñeras, porteras, limpiadoras) se están renovando, a raíz de la recesión, por la reactivación de los campos transnacionales, construidos a través de las redes sociales tejidas por las diferentes corrientes migratorias El texto señala como estos campos transnacionales se cruzan con las cadenas globales de producción y reproducción, en términos de reorganización patriarcal del mercado de trabajo y de la fuerza laboral, de tal manera que la crisis económica ha traído consigo un reforzamiento de los canales tradicionales de reproducción social a través de los yacimientos laborales generizados.
Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole Body Radiation: An in Vivo 1H MR Spectroscopy Study
Authors: Rana Poonam , Khan Ahmad Raza , Gupta Mamta Aryabhushan , Khushu Subash
Published: December 2017

Whole body radiation exposure induced injury may occur during medical or industrial accidents as well as during terrorist radiation exposure scenario. A lot of information is available on alterations in brain function and metabolism post localised cranial irradiation; changes in brain associated with whole body radiation exposure are still limited. The present study has been conducted to assess early differential effect of low and high whole body radiation exposure on hippocampus neurometabolites using in vivo proton magnetic resonance spectroscopy (1H MRS). Hippocampal 1H MRS was carried out in controls (n = 6) and irradiated mice exposed to 3 Gy, 5 Gy, and 8 Gy of radiation (n = 6 in each group) at different time points i.e., day 0, 1, 3, 5 and 10 post irradiation at 7 T MRI system. Quantitative assessment of the neurometabolites was done using LCModel. The results revealed significant decrease in myoionisitol (mI)/creatine (tCr) and taurine (tau)/tCr in animals exposed to 5 Gy and 8 Gy dose compared to controls. In 3 Gy dose group, none of the metabolites showed significant alterations at any of the time point post irradiation as compared to controls. Overall our findings suggest differential change in hippocampal volume regulatory mechanism associated neuro-metabolites following whole body radiation exposure with maximum reduction in case of high dose group. We speculate that these alterations may be a consequence of oxidative stress, neuro inflammation or systemic inflammatory response following whole body radiation exposure.
Physico-chemical Characteristics of Fine Nano-scaled Carbon Fibers from Bacterial Cellulose
Authors: Swaminathan Jiji , Kadirvelu K. , Rajendran Deepika
Published: December 2017

Recently, carbon nanofibers have gained immense attention in research due to its tremendous application. Here, this work highlights a simple, cost effective and reliable method to develop carbon nanofibers (CNF) from biomass. The biomass used is bacterial cellulose (BC) synthesized using Acetobacter xylinus. CNF was developed by freeze drying of BC followed by pyrolysis at different temperatures (300ºC - 900ºC). The conversions of BC to CNF were characterized using SEM, FTIR, TGA and XRD respectively. The results exhibit three dimensional, lightweight, fine nanoscale fibers with a diameter of 10nm which are tend to have hydrophobic and lipophilic characters, due to which it can be used in oil – water separation applications. 
Computer Graphic and Photographic Image Classification using Local Image Descriptors
Authors: Birajdar Gajanan K , Mankar Vijay H
Published: December 2017

With the tremendous development of computer graphic rendering technology, photorealistic computer graphic images are difficult to differentiate from photo graphic images. In this article, a method is proposed based on discrete wavelet transform based binary statistical image features to distinguish computer graphic from photo graphic images using the support vector machine classifier. Textural descriptors extracted using binary statistical image features are different for computer graphic and photo graphic which are based on learning of natural image statistic filters. Input RGB image is first converted into grayscale and decomposed into sub-bands using Haar discrete wavelet transform and then binary statistical image features are extracted. Fuzzy entropy based feature subset selection is employed to choose relevant features. Experimental results using Columbia database show that the method achieves good detection accuracy.
Model of Optimal Cooperative Reconnaissance and its Solution using Metaheuristic Methods
Authors: Stodola Petr , Mazal Jan
Published: December 2017

The model of optimal cooperative reconnaissance as a part of the tactical decision support system to aid commanders in their decision-making processes is presented. The model represents one of the models of military tactics implemented in the system to plan the ground reconnaissance operation for the commander optimally. The main goal of the model is to explore the area of interest by multiple military elements (scouts, UAVs, UGVs) as quickly as possible. A metaheuristic solution to this problem which combines two probabilistic methods: simulated annealing and the ant colony optimisation algorithm is proposed. In the first part of this study, the optimal cooperative reconnaissance problem is formulated. Then, metaheuristic solution, which is composed of three independent steps, is presented. Finally, experiments are conducted to verify the approach to this problem.
On Walsh Spectrum of Cryptographic Boolean Function
Authors: Pandey Shashi Kant , Dass B. K.
Published: December 2017

Walsh transformation of a Boolean function ascertains a number of cryptographic properties of the Boolean function viz, non-linearity, bentness, regularity, correlation immunity and many more. The functions, for which the numerical value of Walsh spectrum is fixed, constitute a class of Boolean functions known as bent functions. Bent functions possess maximum possible non-linearity and therefore have a significant role in design of cryptographic systems. A number of generalisations of bent function in different domains have been proposed in the literature. General expression for Walsh transformation of generalised bent function (GBF) is derived. Using this condition, a set of Diophantine equations whose solvability is a necessary condition for the existence of GBF is also derived. Examples to demonstrate how these equations can be utilised to establish non-existence and regularity of GBFs is presented.
Interpolacion Regnie para lluvia y temperatura en las regiones andina, caribe y pacífica de Colombia
Authors: Alzate Velásquez Diego Fernando , Araujo Carrillo Gustavo Alfonso , Rojas barbosa Edwin Oswaldo , Gomez Latorre Douglas Andres , Martínez Maldonado Fabio Ernesto
Published: December 2017

Se utilizó el modelo regionalizado de lluvia Regionalisierte Niederschlage (Regnie) para interpolar la lluvia y temperatura media del aire de las regiones Andina, Caribe y Pacífica de Colombia. Este modelo integró los datos de la pendiente y exposición del terreno obtenidos del modelo digital de elevación, así como los promedios climatológicos de 1440 series de precipitación y 258 series de temperatura registradas en igual número de estaciones meteorológicas de superficie para cada variable. Se establecieron los modelos de regresión lineal múltiple de la precipitación media anual y temperatura media anual del aire, además se utilizaron herramientas de geoprocesamiento para la generación de las superficies interpoladas. Los estadísticos de prueba de las superficies Regnie fueron similares a los obtenidos con interpolaciones con los métodos Spline e IDW para precipitación (coeficiente de determinación 0.81 y error medio de 55.6 mm) y mejores para la temperatura media (coeficiente de determinación 0.99 y error medio de 0.02°C).
Impacto de Alnus acuminata Kunth en los flujos de N2O y calidad del pasto Pennisetum clandestinum Hochst. ex Chiov.
Authors: Silva Parra Amanda , Garay Rodriguez Seydyss , Gómez Insuasti Arturo Samuel
Published: December 2017

El Aliso Alnus acuminata Kunth es un forestal del trópico alto de Colombia que se asocia con pasto Pennisetum clandestinum Hochst. ex Chiov. como sistema silvopastoril (SSP) y fija N atmosférico. El SSP se comparó con 0, 50, 100, 150 y 200 kg.N.ha-1.año-1 a los 30, 45 y 60 días sobre la calidad del pasto, expresada en forraje verde (FV), materia seca (MS), porcentaje de proteína cruda (%PC) y N absorbido; también se evaluaron los flujos de emisiones de N2O a la atmósfera. El SSP superó a 0 y 50 kg.N.ha-1 en todas las variables, menos en los flujos de emisiones de N2O que fue mayor a 0 kg.N.ha-1 (P<0.05) e igual a 50 kg.N.ha-1 (P>0.05) y en FV fue similar a 100 kg.N.ha-1 (p>0.05); 150 y 200 kg.N.ha-1.año-1 superó en todas las variables al SSP. Se alcanzó mayor FV y MS a los 45 días y %PC a los 30 días.
Efecto de inclusión de anticoagulantes durante el beneficio de Hevea brasiliensis (Willd. ex A.Juss.) Müll.Arg.
Authors: Mendoza Vargas Lina Paola , Jimenez Forero Javier Alexander
Published: December 2017

Se evaluó el efecto de un agente anticoagulante del látex en el árbol de caucho (Hevea brasiliensis). Se caracterizó el contenido de solidos totales (TSC) y contenido de caucho seco (DRC) del látex, se evaluaron cuatro tratamientos de anticoagulantes en campo: (T1) amoniaco, (T2) bórax, (T3) amoniaco-bórax y (T0) sin anticoagulante. En las láminas se evaluaron cinco diluciones (v/v) de látex en agua D1 (100 %), D2 (75 %), D3 (50 %), D4 (25 %) y D5 (0 %), a estas se hicieron pruebas de tensión, compresión y espesor. El látex caracterizado obtuvo TSC (37.1 %+0.27), DRC (34.3 %+0.19). Encontrándose en T3D1 mayor resistencia de tensión hasta punto de ruptura de 13.37 KgF, compresión de 5 KgF, y menor espesor de 1.52 mm, sin diferencia significativa entre los tratamientos T3 y T2 y las diluciones D1 a D2, posibilitando reducir el consumo de agua (25 %), y la producción de ripio (38 %) con anticoagulantes, sin afectar negativamente sus propiedades mecánicas.