bluuebunny/crossref_metadata_2025 huggingface dataset:
Distributed multiple-bipartite consensus in networked Lagrangian systems with cooperative-competitive interactions
Authors: Zhang Tiehui , Li Hengyu , Liu Jun , Lu Daowei , Xie Shaorong , Luo Jun
Published: February 2021

In combination with the collective behavior evolutions of bipartite consensus and cluster/group consensus, this paper proposes the notion of multiple-bipartite consensus in networked Lagrangian systems (NLSs). The distributed leaderless and leader-following multiple-bipartite consensus control laws for NLSs are presented in the cooperative-competitive network, where the negative interactions between agents can exist in the same subnetwork. By introducing an acyclic partition and adding the integral item in the control protocols, the final explicit convergence states in the leaderless case are eventually obtained. Moreover, the leader-following scenario can be realized in fifinite time with integrated controllers. All of the effectiveness has been illustrated through numerical simulations.
Mobile App Usage Pattern prediction using Hierarchical Flexi-Ensemble Clustering (HFEC) for Mobile Service Rating
Authors: Priyanga P. , Kamal A. R. Nadira Banu
Published: February 2021

Background: Nowadays, the mobile app market becomes rapidly increased in world wide. The mobile app marketers have smart enough to understand the requirements and demands of customers and perform their aspirations. They delight them. It provides growth, profitability, and creativity with lot of inventions. The main aim of this research is to analyze the customer interest and preferences of mobile service providers.Methodology: This paper proposed the clustering model named as Hierarchical Flexi-Ensemble Clustering (HFEC). It provides the final result with robustness and improved quality. Before clustering, the unwanted features are removed by using the Genetic Algorithm based on the Collective Materials (GACM) technique. The customer preferences are analyzes with the clustering of mobile usage patterns. Results: The analysis determined that the app usage pattern based on the most frequent word, rating category, rating character count, rating word count and content-based rating in the google play store app dataset. Finally, the results are compared with the existing methods to analyze the superior performance of proposed method. The comparison analysis is estimated based on the based on the average hit rate at different cache sizes.Conclusion: The work is concluded with the app pattern prediction in the form of clustering for app marketing service. From the marketing side, they can analyze the customer preferences and satisfaction.
Low Socioeconomic Status is a Risk Factor for Delay to Treatment and Mortality of Testicular Cancer Patients in Hungary. A Prospective Study
Authors: Küronya Zsófia , Fröhlich Georgina , Ladányi Andrea , Martin Tamás , Géczi Lajos , Gyergyai Fruzsina , Horváth Orsolya , Kiszner Gergő , Kovács Ágnes , Dienes Tamás , Lénárt Enikő , Nagyiványi Krisztián , Szarvas Tibor , Szőnyi Mihály , Tóth Attila , Biró Krisztina
Published: February 2021

Background. In Hungary, the mortality rate for testicular germ cell cancer (TGCC) is 7.6% which is significantly higher than the EU average. We prospectively evaluated the effect of socioeconomic status on patient delay, doctor’s delay, and therapy outcomes.Methods: Questionnaires on subjective (MacArthur Subjective Status Scale), objective (wealth, education, and housing data) social status, and on patient’s and doctors’ delays were completed by newly diagnosed TGCC patients.Results: Patients belonged to a relatively high socioeconomic class, a university degree was double the Hungarian average, Cancer-specific mortality in the highest social quartile was 1.56% while in the lowest social quartile 13.09% (p=0.02). In terms of patient delay, 57.2% of deceased patients waited more than a year before seeking help, while this number for the surviving patients was 8.0% (p=0.0000). Longer patient delay was associated with a more advanced stage in non-seminoma but not in seminoma, the correlation coefficient for non-seminoma was 0.321 (p<0.001). For patient delay, the most important variables were the mother’s and patient’s education levels (r=-0.21, p=0.0003, and r=-0.20, p=0.0005), respectively. Since the patient delay was correlated with the social quartile and resulted in a more advanced stage in non-seminoma, the lower social quartile resulted in higher mortality in non-seminoma patients (p=0.005) but not in seminoma patients (p=0.36) where the patient delay was not associated with a more advanced stage.Conclusions: Based on our result, we conclude that to improve survival, we should promote testicular cancer awareness, especially among the most deprived populations, and their health care providers.
Results from the first Culturally Tailored, Multidisciplinary Diabetes Education in Lebanese Adults with Type 2 Diabetes: Effects on Self-Care and Metabolic Outcomes.
Authors: Sukkarieh-Haraty Ola , Egede Leonard E. , Khazen Georges , Kharma Joelle Abi , Farran Natali , Bassil Maya
Published: February 2021

Objective: This pilot-study tested the effect of culturally-tailored education targeting diabetes self-care on glycemia and cardiovascular risk factors of Lebanese with type 2 diabetes (T2DM). Methods: A sample of 27 adults (Age: 61±10yrs, 59% males, HbA1c:8.98±1.38%) with T2DM was recruited from primary health care centers in Beirut. Participants received culturally tailored, multidisciplinary education. Scales assessing self-care, social support, fatalism, and diabetes knowledge, as well as anthropometric measures, and blood samples were collected at baseline, 3-months and 6-months post- intervention. Results: Diabetes self-care (Diet, Self-Monitoring Blood Glucose and foot care) improved after 6 months, which was reflected in a significant drop in glycemic level (HbA1c:-0.5%; FPG: -38 mg/dl), and cholesterol/HDL ratio (4.45±1.39 vs. 4.06±1.29). Waist circumference decreased at 6 months compared to 3 months (p<0.05). Conclusion: This is the first effective culturally-tailored intervention that improved self-care, glycemic control, body adiposity and blood lipids of Lebanese with T2DM. Larger scale implementation with representative sample is warranted.
Impact Of Social Capital , Gender And Education On The Utilization Of Public Health Services: A Cross Sectional Study Based On The China Migrant Dynamic Survey
Authors: Yang Zhen , Jiang Chenghua
Published: February 2021

Background: China is making every effort to promote equal access to public health services(PHS) for the internal migrants. Studies have demonstrated that the impact of social capital on PHS is different among subgroups of people. Clarifying these differences will help China accurately promote the equalization of PHS for the internal migrants and provide reference for other developing countries.Methods: Data from the China Migrant Dynamic Survey of 2017, involving 130642 migrants in 31 provinces were used to clarify the complex relationship between social capital and the utilization of National Essential Public Health Services (NEPHS). Social capital was divided into regional cognitive social capital (RCSC), regional structural social capital (RSSC), individual cognitive social capital (ICSC), and individual structural social capital (ISSC). Then, multi-level logistic regression was conducted to analyze their impacts on the utilization of NEPHS of the migrants, and whether such effects are moderated by gender and education. Results: The results suggest: (1) There are significant differences in the levels of CSC, SSC, and NEPHS utilization between different genders and educational subgroups of the migrants, among which the educational difference is more prominent. (2) An interaction exists between the levels and dimensions of social capital and NEPHS projects. Also, the impact of SSC on NEPHS is always greater than that of CSC at the same level. (3) The effects of RCSC, RSSC, ICSC, and ISSC on NEPHS utilization by migrants are not moderated by gender. However, education could weaken the relationship between RCSC and health education, ISSC and health education, and RSSC and health records but strengthen the correlation between RSSC and health education. Conclution: This study demonstrated complex interactions between the dimensions and levels of social capital, NEPHS projects, and the population characteristics of migrants. As the government strives towards the equalization of NEPHS, these interactions should be fully considered.
Investigating the synergistic effect of UV/PS/TiO2 and UV/PI/TiO2 processes on paraquat herbicide degradation in media aqueous: statistical optimization, kinetic study, and estimation of electrical energy consumption
Authors: Ghavi Azam , Bagherian Ghadamali , Vahidian Hadi Rezaei
Published: February 2021

In this paper, the performance of UV/PS/TiO2 and UV/PI/TiO2 as hybrid AOPs for degradation of paraquat (PQ) herbicide in aqueous solution has been studied. The effect of several factors such as UV irradiation, initial oxidant concentration, nano-TiO2 (TiO2NPs) dosage, and pH on the degradation efficiency was investigated. Process optimization was performed by Central Composite Design (CCD) and response surface methodology (RSM) for 30 mgL− 1 of herbicide at 25 ˚C and 40 min. Based on the results, for UV/PS/TiO2 process a degradation efficiency of 83% was obtained in the optimum condition of initial PS concentration of 400 mgL− 1, initial TiO2NPs concentration of 150 mgL− 1, and pH = 6.3. Also for UV/PI/TiO2 process, 87% degradation efficiency was achieved in the optimum condition of initial PI concentration of 88 mgL− 1, initial TiO2NPs dosage of 125.5 mgL− 1, and pH of 7.5. Mineralization efficiency of the PQ solution by using PS and PI were about 47.5% and 57%, respectively after 80 min. Kinetic studies showed that both process follow pseudo-first-order kinetic model and their kinetic constants were 0.0299 min− 1 for PS process and 0.0604 min− 1 for PI process. Electrical energy consumption was estimated about 481.60 kWh/m3 for PS process and 238.41 kWh/m3 for PI process.
Coronavirus Disease-19 Outbreaks In Iraq: A Case Report
Authors: Aljumaili Mohammed
Published: February 2021

Coronavirus is a new pandemic disease that has emerged in Wuhan, China, and then spreads around the world. The cases number of the COVID-19, which have been daily reported in Iraq, has risen slowly. However, no confirmed study has been undertaken to evaluate the situation of the COVID-19 in concerning the confirmed cases, death cases, and recovered. The current study is undertaken to describe and assess the COVID-19 of the present situation in Iraq out of the range of the confirmed, deaths and recovered cases from the date 21 February to 30 April 2020 in Iraq. The study findings have revealed that there is a gradual increase of COVID-19 cases onwards until the top peak in 7th Apr. in which the cases reach 684, then decrease regularly. The total infected people of the study scope is 2085 persons according to the Ministry of Health in Iraq, while the world health organization (WHO) states 2003 person. The spatial distribution quantile map showed the hot spots in the province of Babylon, Maysan, and Diyala. However, less was found in three provinces (Nineveh, Salahaddin, and Al Anbar). The result shows that 66.9% recovered and 4.6% death cases out of total infected people. According to the procedures of Iraqi government, and many international reports that predict the end of this pandemic in the world will be doubtful as there is many vaccine under development.
Infectious Subgenomic Amplicons method to expedite reverse genetics of SARS-CoV-2 and other coronaviruses
Authors: Mélade Julien , Piorkowski Géraldine , Touret Franck , Fourié Toscane , Coutard Bruno , Nougairede antoine , de Lamballerie Xavier
Published: February 2021

There is a need for simple reverse genetics methods to decipher the biological properties of animal and human coronaviruses. Here, we attempted to rescue the recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the Feline enteric coronavirus (FeCoV) using the rapid “Infectious-Subgenomic Amplicons” (ISA) method. For each virus, transfection into permissive cells of eight overlapping subgenomic cDNA fragments covering the entire genome allowed reconstruction of the complete virus genome and generated infectious viral particles. Rescued viruses replicated the phenotypic and genotypic characteristics of the original isolates. In conclusion, the ISA method, which had been previously used for RNA viruses with shorter genomes (e.g., flaviviruses, alphaviruses and enteroviruses) can be used to rescue viruses with substantially longer genomes and usefully complements pre-existing methods for reverse genetics of coronaviruses. Its extreme simplicity and versatility makes it a strong option to decipher the biological properties of coronaviruses circulating in human, domestic or wild fauna populations.
Stressed, but connected
Authors: Riesmeyer Claudia , Pohl Elena , Ruf Larissa
Published: February 2021

Among social network sites (SNS), Instagram has become one of the most important platforms for adolescents (age 10–19 years), especially in Germany. They use it to share experiences and meaningful content and above all, to interact with their peers. Norms, defined by the peer group, influence adolescents’ behavior, online as much as offline. This influence on aligning one’s needs with expectations in the SNS environment leads to pressure. How adolescents perceive this pressure from their peer group in detail on Instagram and how they cope with it has seldom been the focus of qualitative research within communication studies thus far. What patterns and potential coping strategies become apparent in adolescents’ behavior? Do these strategies tend to be problem-solving or avoidant oriented? This paper addresses this need and uses in-depth interviews, drawn via purposive sampling, with 30 adolescents to investigate the strategies adolescents develop to cope with perceived forms of peer pressure. Results show that the peer group has both positive and negative effects on adolescents. Positive in that they are an important reference for adolescents, an effect, that is enhanced by Instagram, which allows interpersonal connections with peers. Then again negative in that adolescents, among other things, feel pressure to communicate with the group and to follow its aesthetic ideals at Instagram in order not to be excluded from the group or otherwise sanctioned. In order to deal with this perceived peer pressure, adolescents develop both active (problem-solving oriented) and avoidant coping strategies, including designing their own media environment according to their needs, supporting each other, and encouraging each other in their own actions. In these coping strategies, the peer group can again have positive or negative impacts. Positive, e.g., as adolescents can share their experiences; negative, e.g., as adolescents might obey the group norms disregarding their personal interests. The findings thus highlight the need to support adolescents in coping with these forms of peer pressure. To be able to act and counter the perceived pressure, adolescents need motivational, emotional, and reflexive skills that can be promoted through media literacy programs.
Atividade antimicrobiana da Melaleuca alternifolia e sua aplicação na Odontologia
Authors: Sampaio Lorena Thays Rodrigues , Oliveira Heloísa Mara Batista Fernandes de , Oliveira Filho Abrahão Alves de
Published: February 2021

Introdução: As bactérias são seres que podem habitar a microbiota normal humana e também podem desencadear infecções. A cavidade oral é colonizada por milhares de microrganismos e o aumento da resistência bacteriana sugere alternativas à utilização de antibióticos. Estudos com a Melaleuca alternifolia têm demonstrado sua ação antimicrobiana sobre esses microrganismos e potenciais usos na odontologia. Objetivo: realizar uma revisão sobre os aspectos botânicos e farmacológicos da Melaleuca alternifolia e sua aplicação como antimicrobiano na odontologia. Material e método: Trata-se de uma revisão narrativa de literatura. Os dados foram coletados de 16 de setembro a 04 de outubro de 2019 nas plataformas Google Acadêmico, SciELO, PubMed e periódicos CAPES, utilizando os descritores: Melaleuca alternifolia, antimicrobiano, fitoterapia e odontologia. Todos os artigos foram analisados e apresentaram a temática elencada para a pesquisa. Resultados e discussão: A Melaleuca alternifolia, também conhecida como árvore do chá é uma planta nativa da Austrália, pertencente à família Myrtaceae, apresentando ação bactericida principalmente devido ao terpinen-4-ol, principal constituinte químico do óleo essencial da planta, o qual tem demonstrado ação sobre Streptococcus mutans e Enterococccus faecalis, dentre outros microrganismos, incluindo vírus e leveduras, podendo ser aplicado na prevenção da doença cárie, como enxaguatórios bucais e como coadjuvante no tratamento endodôntico. Conclusão: Portanto, a utilização da Melaleuca alternifolia para tratar doenças decorrentes de infecções bacterianas na odontologia é de excelente escolha, no entanto, é necessário mais estudos a cerca dos constituintes químicos da planta.
PROTEOLYTIC SYSTEM CONDITION AS IN THE CASE OF NEUTROPHIL ELASTASE IN PATIENTS WITH TROPHIC ULCERS ON THE BACKGROUND OF DIABETES MELLITUS
Authors: Nikolaienko A.S.
Published: February 2021

According to the WHO and the International Diabetes Federation (IDF), the number of patients with diabetes in the world reached 463 million people in 2019. A typical manifestation of complications of diabetes mellitus is the development of trophic ulcers of the lower extremities, which leads to poor quality of life, disability, and high financial costs for treatment.
COMBINED ESTROGENOLIPOSOMAL THERAPY IN COMPLEX TREATMENT OF PYOINFLAMMATORY SOFT TISSUE LESIONS IN ELDERLY AND SENILE PATIENTS
Authors: Lihonenko O.V. , Zhdanov S.M. , Storozhenko O.V. , Zubaha A.B. , Shumejko I.A.
Published: February 2021

Wound healing in the elderly and senile is slower than in the young, one explanation for this is a decrease in estrogen levels and poor functioning of cells involved in various phases of the wound process.
A Cyborg-animal Image in B. Werber's Work "Her Majesty the Cat"
Authors: Poltoratska Alla
Published: February 2021

The article focuses on the novels «Tomorrow The Cats» (2016) and «Her Majesty the Cat» (2019) by French author B. Werber, in which the author presents one of his options for the future interaction of a man with an animal, where the latter is depicted outside the traditional perception of a man. The work explores the writer’s vision of future relationships between species and the conditional symbiosis of animals and people in order to save both. The study examines cyborg-animals that strive to change the world order. The writer in the novels presents a new level of human interaction with another (laboratory animal, cyborg animal) and calls for revision of the generally accepted human perception of animals. A man must abandon traditional highness and consider ways to stop environmental problems, among which are the extinction of rare species of animals. The author tries to warn a person, therefore describes a number of situations in which a man appears to be cruel to the world around, and to protect a future man from results of her own actions. Against the background of the war, the author depicts the problem of human interaction with the outside world, in which the threat to everything alive is not only looting, plague, but also the invasion of rats who seek to dominate the city. For general salvation, animals unite with people, which makes it possible for the writer to interpret the image of an animal as a species close to humans. B. Werber says that the mission of people on earth is changing, they should worry not only about their species, but also about the world around and notes «The Earth is laid to the same extent to all forms of life, animals or plants that inhabit it. And no species objectively has the right to proclaim itself "higher than others"».
Language Milton-model Analysis in Political Discourse
Authors: Kovalevska Anastasia
Published: February 2021

The article is dedicated to the analysis of the verbal influence (also known as suggestion) realization phenomenon in political discourse, which is usually understood as a holistic combined image of the text (be it an advertisement slogan, a political program, a speech, or an interview) itself and the emotions of its recipient and addressee. and is aimed at a a political subject’s (politics, political force, power) influencing a political object (audience, electorate, voter). The political discourse is studied from the standpoint of Psychology, Communicative Linguistics, Sociolinguistics, Speech Acts Theory, Advertisement Theory, PR / GR, Political Linguistics and other related sciences, but it is the involvement of such new methods of studying the linguistic and extralinguistic implementation of suggestion in political discourse, influence being its basic function, that emphasizes the relevance of the work, aimed at studying the manifestations of suggestion in political discourses with the help of NLP’s Milton-model analysis. Contemporary political discourse as an array, which, given the specificity of its functioning in today's information society, is characterized by immanent suggestogenicity is the object of the research; while the essential linguistic features of political discourse as a tool for the realization of its programmed suggestibility are the subject.
The factual data of the research is represented by recorded media speeches, political advertisement, political programs and press conference speeches of the politicians heading the governments of Ukraine, USA, France, Spain, Italy, Canada, Germany (about 200 items of each class). The author involves the meta- and Milton-model analysis of the text having been researched and developed in the NLP paradigm in order to isolate the actual linguistic influential patterns (markers of language metamodeling processes, simple, complex and indirect inductions).
The linguistic algorithm of Milton-model analysis of political discourses having been researched and visually illustrated with relevant examples combines a complex scientific approach within such multisubstrate science as NLP, and thus it will allow not only to single out dominant strategies of constructing texts and mechanisms of these discourses, but also to highlight the ways to counteract their negative effect, as well as serve in the construction of appropriate planning decisions in the field of optimizing the effectiveness of political communication, emphasized the prospects of the research having been presented in the article, as well as its essential practical value.
Recombination of the Character in the Story by V. Petrov «An Enamalled Bowl»
Authors: Kravchenko Valentina
Published: February 2021

The investigation article is carried out on the basis of the story «An Enamelled Bowl» by V. Petrova. It traces a chronotopic model, which is archetypal for V. Petrov’s works: human existence in times of ideological change becomes catastrophic for it, because it is «reprogrammed»; the worldview, psychology and morality are comprehended, the social values of the artist are defined in order to realize the spiritual and aesthetic essence of the character of the work; the author’s artistic mechanisms of their embodiment are revealed; the development of the conflict is traced to show the confrontation of different ideas.
In study brought the focus is on the fact that the inner freedom of uniqueness is the basis of existential morality – people place confidence in myself, have a guard in oneself, frankness with oneself is the opposition of world disharmony.
The system of figurative-expressive means and techniques are analyzed, in particular, the landscape, which enhances the tragedy of the situation, dialogues that dramatize the action, the symbolism of color, descriptions of the interior, which help to create a psychological portrait of the character.
In the work emphasize a point that the idea of human life, asserted by V. Petrov, gives rise to another – the idea of self-denial in the name of work for the benefit of mankind.
The writer’s understanding of rigidity, as a statement of the inviolability of power, clearly correlates with the aesthetic pursuits of V. Petrov, consistent with the new aesthetic and philosophical views in Europe.
A business transformation model to enhance the sustainability of small-sized family businesses
Authors: Wijayanti Anita , Kamalrudin Massila , Sidek Safiah , Hendra Titisari Kartika
Published: February 2021

Business transformation is essential to making the small-sized family business more sustainable. Technological and environmental changes have radically transformed the way of doing business. Business transformation into digital business is the key to success in these conditions. On the other hand, some of the previous studies of business transformation in several countries and industries show different empirical evidence. This study analyzes the transformation process in a small-sized family business. This is a case study of 15 small-sized family businesses with four different types of industry, with an interview and observation period of 12 months in 2019–2020. This study has formulated a business transformation model for a small-sized family business and presented the results of the transformation process carried out. The research results indicate that a business transformation model consists of several attributes and sub-attributes. Business transformation results indicate different processes and times between companies. In general, the transformation process can be grouped into the exploration, learning, and synchronizing stages. The industry with the fastest transformation process is the hospitality industry, while the manufacturing process for the industry takes a bit longer. The results of this study indicate that business transformation has improved the sustainability of a small-sized family business that is characterized by its ability to adapt to changing technology and environmental conditions.
HIGH RESOLUTION LC-MS/MS SCREENING FOR SECONDARY METABOLITES IN BULGARIAN SPECIES OF GENUS Astragalus L.
Authors: Shkondrov Aleksandar , Krasteva Ilina
Published: February 2021

The phytochemical content of some Astragalus species distributed in Bulgarian flora has been previously studied. Among other compounds, flavoalkaloids, acylated flavonoids, flavonoid triglycosides and cycloartane saponins have been isolated so far. The composition of the rest of the representatives of this genus in Bulgaria is not explored yet. The aim of this study was to perform a screening for the presence of selected rare secondary metabolites (flavoalkaloids, acylated flavonoids, flavonoid triglycosides and cycloartane saponins) in selected Astragalus species. Samples were collected in different phenological stages and from different locations in the country. A novel and rapid ultra-high performance liquid chromatography – high resolution electrospray ionisation mass spectrometry (UHPLC-HRESIMS) method was developed and applied. For the first time a flavoalkaloid glycoside was determined from extracts of A. onobrychis var. chlorocarpus and A. glycyphylloides. From A. depressus an acylated derivative of kaempferol was newly identified. The flavonol triglycosides camelliaside A, alcesefoliside and mauritianin were proved in samples of A. glycyphylloides, A. onobrychis var. chlorocarpus and A. cicer for the first time as well.
Individual and social determinants for the formation of identity: A comparative analysis of research strategies
Authors:   Lomonosov Moscow State University, Dryaeva Ella D. , Kanaev Ilya A. ,   Sun Yat-sen University
Published: February 2021

This article investigates the concept of identity: the research objective is to consider the principles that can be used to unite various approaches to describing the emergence and transformation of human identity. The research method is a comparative analysis of significant theories of Western philosophy in terms of the achievements of modern interdisciplinary research. Within Western philosophy, most concepts of identity can be classified as belonging to individual- centric or socio-centric research models. Therefore, such a distinction serves as the starting point to discuss the emergence and transformation of the concept of identity. The provided analysis reveals two facts. First, the investigation starts either from individual human experience or from social communication structures, this choice determining further research as individual-centric or sociocentric. Second, it is ultimately impossible to reduce an individual experience or social effect to their opposition: both individual and social beings determine the emergence and functioning of human identity. Hence, human identity should be considered as a result of interaction between individual and social beings. Within contemporary epistemology, the activity realism approach provides a theoretical foundation for explaining identity as an outcome of human active cognition and the transformation of the environment. Thus, this article provides a theoretical foundation for the empirically confirmed fact that human identity is determined by all influential factors present in the lifeworld. Any theory that neglects any efficient causes for the formation of identity in concrete circumstances of time, space, and culture inevitably fails. The practical value of this article is to create a theoretical foundation for empirical research on natural or artificial transformations of human identity in specific circumstances of cross-cultural communication and competition.
Philosophical and scientific interaction between Vladimir Vernadsky and Pavel Florensky
Authors:   University of Ostrava, Naldoniová Lenka
Published: February 2021

The article focuses on the philosophical and scientific dialogue between Vladimir Vernadsky and Pavel Florensky in the context of Russian philosophy. Florensky formulated his philosophy in the book The Pillar and Ground of the Truth, making a great impact on Vernadsky. The two philosophers exchanged their thoughts through letters. During the time of his imprisonment, Florensky wrote letters on scientific topics to his son Kirill, who worked with Vernadsky. Thus, Kirill Florensky became the point of contact between the two thinkers. The present article aims to show the complementarity between Vernadsky’s and Florensky’s work with a particular emphasis on their conception of noosphere-pneumatosphere connected with Plato’s methaphysics, which Florensky interpreted as the world of the Truth or absolute reality. Through investigating Vernadsky’s and Florensky’s letters and diaries and comparing their conceptions of noosphere and pneumatosphere, as well as their interpretation of reality in their writings, it is possible to determine influences of the concepts important for Russian religious philosophers, such as a tendency towards wholeness and intuition. The first part of the article examines Vernadsky in relation to Russian idealists, the second part of the article is focused on the relationship between Vernadsky and Florensky, and the third on the concepts of noosphere, pneumatosphere, and the concept of reality (living being) — absolute reality (Truth). Through these three steps, the complementarity of Vernadsky’s and Florensky’s interpretations are illustrated. Their interpretations are not contradictory because while Vernadsky dealt with Earth’s reality and its evolution, and Florensky focused on the metaphysical world, both were interested in the evolution of the biosphere-noosphere/pneumatosphere through the activity of man. The article is the first study in English focused on the scientific and religious-philosophical interaction between Vernadsky and Florensky.
The interrelationship between consciousness and sensuality in Nāgārjuna’s philosophy
Authors:   Institute for Mongolian, Buddhist and Tibetan Studies, Lepekhov Sergey Yu.
Published: February 2021

The interrelationship between consciousness and sensuality is a significant problem in many philosophical systems. The peculiarities of religious philosophy consists in the congruence of using argumentation with the basic religious dogmata, which are unchangeable and uncritiqued. This aspect, in turn, stimulates the development of exegetics and hermeneutics. In comparison with the Western philosophy, the particularity of Indian and Buddhist philosophy infers a larger quantity of polemical materials directed against the representatives of other competing schools. This article discusses the formation of the concept of “sensuality” in various Buddhist schools (Theravāda, Sarvastivāda, Madhyamaka) and the mutual conditionality of the sensual and mental (nāma-rūpa) in the conceptions of Theravādins and Sarvastivādins is noted. The peculiarities of using the terms “Hīnayāna” and “Hīnayānist” in Mahāyāna texts are explained. The representatives of Theravāda and Madhyamaka distinguished the terms of “clear sense” and “hidden sense”, which, in turn, led to the appearance of the concept of “two truths” in Nāgārjuna’s philosophy. The particularities of his argumentation regarding sensuality’s absence of self-nature (rūpa) and his analysis of the various aspects of reality (including illusions, perceived as real ones) make it possible, which Nāgārjuna could admit, that consciousness could be more real in comparison with sensuality. It is concluded that there are no clear statements by Nāgārjuna about consciousness having an ontological status. In the author’s opinion, the absence of a clear division between “two truths” makes it possible to use this concept in social practice. The author’s translation to Russian of one of Nāgārjuna’s hymns “The praising of inconceivable” (Acintyastava) from Sanskrit and from Tibetan is provided.
Sediments nitrogen cycling influenced by submerged macrophytes growing in winter
Authors: Dan Zhang , Chuan Wang , Qiaohong Zhou , Xingzhong Yuan
Published: February 2021

Restoration of submerged macrophytes is one of the important measures for ecological treatment of eutrophic lakes. The changes in physical and chemical conditions caused by submerged macrophytes also affect the process of benthic nitrogen cycling. The growth period of Potamogeton crispus is mainly in winter. In order to understand the effect of submerged macrophytes growing in winter on nitrification rate and denitrification rate in the process of nitrogen cycling, experiments were carried out from winter to summer with vegetated and non-vegetated treatments. The results showed that the effect of submerged macrophytes on water temperature was not significant in winter. The nitrogen cycling was mainly affected by variables, which were inorganic nitrogen and dissolved oxygen. Submerged macrophytes had little effect on nitrification rate, but had a certain inhibition on denitrification rate by providing oxygen from photosynthesis. In total, submerged macrophytes growing in winter have little effect on nitrogen cycling in sediment. However, submerged macrophytes growing in winter can increase the attachment surface of microbes and inhibit resuspension of sediment, which play a complementary role to submerged macrophytes growing in summer for maintaining stability of eutrophic lakes.
Engineered Polymer Nanoplatforms for Targeted Tumor Cells and Controlled Release Cargos to Enhance Cancer Treatment
Authors: Wang Zhenjie , Tang Longguang , Mu Qingchun , Che Siyao , Sun Yongbing , Bai Lei , Luo Yan , Yang Yeguo , Yu Meng , Yu Zhiqiang
Published: February 2021

Cancer is composed of a series of uncontrollable cells, which finally form tumors
to negatively impact the functions of the body and induce other serious diseases,
even leading to death. During the last decades, scientists have devoted great efforts to
study cancer; however, there are no effective diagnoses and treatments. Nanomaterials
have attracted great attention in the biomedical field in recent years, which are widely
used as optical imaging probes and delivery systems for cancer therapy. Among the numerous
nanomaterials, polymeric nanoparticles occupy a prominent position because of
their tunable micro-size, multifunctional surface, prominent biocompatibility and high
drug-carrying capacity. These significant advantages of polymeric nanomaterials have
significance over the traditional nanomaterials and have become a potential therapy for
cancer. In this review, we focus on the applications of polymeric nanoparticles in cancer
theranostics, especially as the drug delivery systems for cancer treatment. This review
provides an overview on the advancement of synthesis, application of polymeric nanoparticles-
based drug delivery systems and highlights the evaluation for cancer therapy.
Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss
Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole
Derivatives
Authors: Ayar Arif , Aksahin Masuk , Mesci Seda , Yazgan Burak , Gül Melek , Yıldırım Tuba
Published: February 2021

Background:

Pyrrole compounds having a heterocyclic structure are the most researched
and biological activities such as antioxidant and anticancer activities.

Objective:

Herein is a first effort to study the significance of heterocyclic compounds to include
pyrrole and triazolidine-3,5-dion moiety, on the pharmacokinetic, antioxidant activity and cytotoxic
activity on MCF-7 and MCF-12A cell lines.

Method:

The molecular structures of compounds I-XIV were simulated by the theoretical B3-
LYP/DFT method. Pharmacokinetic studies of PhTAD-substituted heterocyclic compounds (IXIV)
were analyzed to show Lipinski's rules via in-silico methods of Swiss-ADME. The drug likeness
calculations were carried out in Molinspiration analyses. Some toxicity risk parameter can be
quantified using Osiris. Antioxidant activities determined by DPPH, Fe+2 ions chelating and reducing.
Cytotoxic activity measured by MTT and RTCA.

Results:

Compared with the DPPH activity, the metal chelating activity exhibited serious similar
antioxidant effects by PhTAD substituted pyrrole compounds. The same compounds showed the
highest activity among the two antioxidant activities. The IC50 values of the compounds are in the
range of 12 and 290 μM in the MCF-7 cell line. In the MTT and RTCA assays, All compounds
showed cytotoxic activity, but about half of the fourteen compounds showed high cytotoxicity. IC50
values of the compounds are in the range of 5 and 54 μM for MTT and range of 1.5 and 44 μM for
RTCA.

Conclusion:

Data of the antioxidant and cytotoxic activity of PhTAD-substituted dihydropyrrole-
derived compounds in MCF-7 and MCF-12A cell lines confirmed that the compounds are biologically
active compound and are notable for anti-cancer researches.
Prediction of Drug-target Binding Affinity by An Ensemble Lear ning System with Network Fusion Information
Authors: Zhang Cheng Lin , Zhang You Zhi , Wang Bing , Chen Peng
Published: February 2021

Background:

Verifying interactions between drugs and targets is key to discover new drugs.
Many computational methods have been developed to predict drug-target interactions and performed
successfully, but challenges still exist in the field.

Objective:

We have made an attempt to develop a machine learning method to predict drug-target affinity,
which can determine the strength of the binding relationship between drug and target.

Methods:

This paper proposes an integrated machine learning system for drug-target binding affinity
prediction based on network fusion. First, multiple similarity networks representing drugs or targets are
calculated. Second, multiple networks representing drugs (targets) are fused separately. Finally, the
characteristic information of splicing drugs and targets was used for model construction and training.
By integrating multiple similarity networks, the model fully embodies the complementarity of network
information, and the most complete features of information can be obtained after the redundancy is removed.

Results:

Experimental results showed that our model obtained good results for DTI binding affinity.

Conclusion:

It is still challenging to predict drug-target affinity. This paper proposes to use an integrated
system of fusion network information for addressing the issue, and the proposed method performs
well, which can provide a certain data basis for the subsequent work.
Dependability in fog computing: Challenges and solutions
Authors:   La Trobe University, Melbourne, Australia, et al. Alraddady
Published: February 2021

The tremendous increase in IoT devices and the amount of data they produced is very expensive to be processed at cloud data centers. Therefore, fog computing was introduced in 2012 by Cisco as a decentralized computing environment that is considered to be more efficient in handling such a plethora in the number of requests. Fog computing is a distributed computing paradigm that focuses on bringing data processing at the network peripheral to reduce response time and increase the quality of service. Dependability challenges of such distributed and heterogeneous computing environments are considered in this paper. Because fog computing is a new computing paradigm, several studies have been presented to tackle its challenges and issues. However, dependability in specific did not receive much attention. In the paper, we explore several solutions to increase dependability in fog computing such as fault tolerance techniques, placement policies, middleware, and data management mechanisms aiming to help system designers choose the most appropriate solution.
Occupational Therapy Interventions for Adolescents: A Scoping Review
Authors: Clarkson Claudia , Boshoff Kobie , Kernot Jocelyn
Published: February 2021

Aim and Background: Occupations are everyday activities that help occupy our time and provide us with a sense of purpose in life. Adolescence is a unique stage of life when individuals experience occupational change that assists with preparation for adulthood. Participation in occupations is linked to health and wellbeing. Existing literature on occupational participation appears to combine adolescents’ and children’s experiences. Due to the unique nature of adolescence and an increased focus on service development and re-design for all age groups in Australia since the implementation of the National Disability Insurance Scheme, this scoping review sought to explore Occupational Therapy interventions that promote adolescents’ participation in everyday occupations. Design and Methods: A systematic search of eight databases for peer reviewed papers published between 2008 and 2018 was conducted. The PRISMA guidelines were used to guide the review processes. Study selection criteria focussed

 

 on Occupational Therapy interventions promoting participation in everyday occupations for adolescents (between 10 to 19 years of age). The data was charted and synthesised to identify key features of the interventions. Results: The 26 included studies revealed various intervention types and adolescent groups. The majority of the interventions targeted adolescents with physical disabilities and autism spectrum disorder. Many studies focussed on promoting functional independence in work, personal care, social participation and health management. Features of interventions include collaborative (with the adolescent and family) intervention goal setting and evaluation processes, as well as the use of technology. The majority of the papers reported positive outcomes, however mixed results were also identified. The findings provide guidance for adolescent service development and re-design by identifying the areas of occupation and features of programs, documented in Occupational Therapy-specific literature. Future reviews can extend our understanding further by incorporating by including publications that focus on assessment and other roles of Occupational Therapists.

Keywords: participation, occupation, Occupational Therapy, adolescents
YouTube as a Source of Patient Information for Exercise and Compensated Maneuver of Dysphagia (Preprint)
Authors: Chang Min Cheol , Park Donghwi
Published: February 2021

BACKGROUND

Acquiring online health-related information has become increasingly widespread.

OBJECTIVE

In this study, we aimed to evaluate the quality of the most viewed YouTube videos on dysphagia on exercise and compensated maneuver.

METHODS

We searched for the keywords “dysphagia exercise,” “dysphagia rehabilitation,” “dysphagia maneuver,” “dysphagia therapy,” and “dysphagia compensation” on YouTube on February 5, 2021. The educational quality of videos on YouTube was investigated based on the Global Quality Scale (GQS) and categorized into three groups: high-, intermediate-, and low-quality. The modified DISCERN tool was used to evaluate the reliability of the YouTube videos. Video parameters were compared between the groups according to the quality of the videos.

RESULTS

Of the 51 videos evaluated, according to the GQS, 54.9% (n = 28), 35.3% (n = 18) quality, and 9.8% (n = 5) were of high-, intermediate- and low-quality, respectively. When the video parameters were compared among the groups, there were no significant differences in the number of views, likes, dislikes, or comments per day (p > 0.05). However, there was a significant difference in the DISCERN scores between the groups (p < 0.001).

CONCLUSIONS

YouTube can be deemed as a predominant source for high-quality videos on dysphagia exercise and compensated maneuvers. However, YouTube should be accepted as a mixed pool with high-, intermediate-, and low-quality videos. Therefore, healthcare professionals, such as physicians and therapists, should verify the suitability and quality of the video, and suggest it to the patient, to ensure that the patient gets the appropriate information.
ЦИФРОВОЙ ДВОЙНИК ТЕХНОЛОГИЧЕСКОГО ПРОЦЕССА ИЗГОТОВЛЕНИЯ ИЗДЕЛИЙ СПЕЦИАЛЬНОГО НАЗНАЧЕНИЯ
Authors: Пантюхин О. , Васин С.
Published: February 2021

Изложена процедура создания цифрового двойника технологических процессов массовых производств. В качестве систем контроля предложено применение современных контрольно-измерительных систем и инспектирующих машин. Для прогнозирования параметров качества изделий на потоке использован математический аппарат теории искусственных нейронных сетей.
МЕТОДИКА СИНТЕЗА УСТАНОВОЧНЫХ ГРУППОВЫХ ИНСТРУМЕНТАЛЬНЫХ НАЛАДОК. ЧАСТЬ 2
Authors: Ракунов Ю. , Абрамов В. , Ракунов А.
Published: February 2021

Рассматривается методика проектирования групповых наладок для научно обоснованной разработки системы автоматизированного проектирования (САПР) оптимальных групповых технологических процессов (ГТП). Приведены принципы проектирования групповых инструментальных наладок (ГИН), методика формализованного выбора и синтеза процесса оптимизации ГИН. Приведена таблица-матрица выбора установочного комплекта ГИН.
Heterogeneity in the productivity of sugar-energy mills in Brazil
Authors: da Silva Haroldo José Torres , Marques Pedro Valentim
Published: February 2021

The development of biofuels in Brazil, and particularly of ethanol as a sustainable energy source, has enabled the strengthening of the national sugar-energy industry. The objective of this study is therefore to evaluate the evolution of the productive efficiency of sugar-energy mills in Brazil during the period of 2006 to 2015, using data envelopment analysis and the Malmquist index and its decompositions. Our results indicate that no single nor well-defined pattern of efficiency or productivity existed among the mills in the industry during the period under study; instead, we found the industry to be heterogeneous in terms of management practices and technology adoption. Furthermore, we found that differences between mills intensified over the period, and that technologically poor mills with low levels of efficiency coexisted among efficient mills employing modern management practices and technologies. Finally, we found that productivity decreased, yet varied considerably over the analyzed period.