bluuebunny/crossref_metadata_2025 huggingface dataset:
Ways to improve the market of green agricultural products in Ukraine
Authors: Yevtushevska O. , Holovachenko L. , Rudnichenko J.
Published: July 2020

Human has been influencing the environment since ancient times, but never has this impact been asintense as in the last century. The use of natural resources is currently occurring at such a large scale and atsuch a rapid rate that the natural reproduction of the environments used is not ensured. As a result, the mu ltifaceted centuries-old human activity has left deep traces on the modern soil and vegetation, air and waterenvironment, wildlife. Today, more and more consumers in the world are aware of the benefits and preferproducts that have a positive impact on the environment and human health. The environmental safety ofagri-food products, whether it is finished products, crop products or livestock products, is a global issue, as itcovers not only human health but also the country's economy. The standard of living of citizens, social acti vity of the person depend on quality of production, and also there is an influence on demographic aspect ofhis existence. Therefore, to ensure a high standard of living, the state must pay more attention to the environmental safety of finished products. The scientific work investigates and highlights the features and currentstate of the market for clean products in Ukraine, determines the level of populations attitude to organicproducts, outlines ways to improve the market for organic products in Ukraine.
Аналіз тенденцій розвитку регіональних ринків мінеральної води України
Authors: Файвішенко Д. С.
Published: July 2020

Сьогодні в умовах трансформації та динамічного розвитку нових сфер економіки, враховуючипозитивну макроекономічну динаміку та соціально-екологічний вплив факторів (загостренняекологічної ситуації, підсилення інтересу до укріплення культурних традицій, зміни споживчихстереотипів), розвиток ринку мінеральної води займає провідні позиції, де домінантною тенденцією єаналіз регіонального ринку. У статті представлено аналіз та моніторинг стану видобутку та тенденційрозвитку регіонального ринку мінеральної води, проведена оцінка бальнеологічних запасів у областяхта виокремлено провідні торгові марки. Зроблено акцент на нівелювання чинників, які негативновпливають на економічний розвиток регіону, просування та вихід на інші регіони торговельних марок іззбереженням територіально-локальних тенденцій. Сформовано з точки зору регіональноїдиференціації виробничих потужностей видобуток мінеральної води в Україні, виокремлено ключовіобласті, яким належить виробництво 50% обсягу даної продукції: Закарпатська, Львівська, Полтавськата Івано-Франківська.
Analysis of the own capital of Ukrainian enterprises and features of its management in the conditions of the new economy of the global market
Authors: Kuprina N. , Markova T. , Stupnytska М.
Published: July 2020

The article notes that the concept of "equity" in the studied literature is considered from the standpoint of economic, accounting, legal and financial management. The analysis of the dynamics and structureof the balance sheet of enterprises by type of economic activity of Ukraine for six years shows an increase inthe balance sheet currency by 90%. An analysis of the statistical dynamics of changes in the structure ofequity of enterprises by type of economic activity of Ukraine over six years shows that since 2014 the structure of registered capital, additional capital has changed dramatically and there is uncovered loss, which hasa negative tendency to increase. The low value of retained earnings and the emergence of losses justifiesthe need for an effective system of equity management, because it is due to this component there is the increase in equity and expansion of economic activity. Tasks for effective management of own capital of enterprises have been defined. The stages of the system of effective equity management of enterprises havebeen proposed.
Current state of fishing industry of Ukraine
Authors: Samofatova V. , Neveseliuk V.
Published: July 2020

The article analyzes the current state of the fishing industry of Ukraine. The legal regulation of thesector and the place of fisheries in the economy of the country have been determined. The list of fish that aremost important for the fishing industry from the Black and Azov Seas and other water reservoirs has beenindicated. The paper considers the volume of fish caught in 2019 in the seas and freshwater reservoirs. Themain exporters and importers of fish products in Ukraine have been listed and the main reasons for smallproduction volumes have been highlighted. It has been proved why it is important to develop aquaculture.Ways to increase the efficiency of fish production have been indicated. It has been claimed that in order torevive the activities of fishing enterprises and the development of the fish market in general, it is necessaryto attract investors and make considerable efforts to support domestic aquaculture.
Дослідження основних проблем щодо мотивації працівників підприємства
Authors: Козак К. Б. , Левчук Ю. С. , Прунчак М. М.
Published: July 2020

Протягом багатьох років вітчизняні компанії не в достатній мірі використовували системи м о-тивації на відміну від закордонних. Відомо, що існуючі способи стимулювання працівників вимагаютьіндивідуального підходу і доопрацювань. В цій статті проаналізовано основні проблеми щодо персо-нальної та групової мотивації персоналу і розглянуті заходи щодо їх удосконалення. Світова практикасвідчіть, що теорії мотивації, які були коли-небудь створені не спростовують одне одного, а навпаки,доповнюють і при правильному комбінуванні можна отримувати нові способи мотивації. Деякі керівни-ки вважають, що витрати коштів на удосконалення процесу мотивації не потрібні. Але насправді, мо-тивовані працівники дають велику віддачу, підвищуючи соціальний і економічний ефект підприємства.Так, на думку експертів, мотивовані працівники підвищують доходи компанії мінімум на 10%, тому су-часний керівник повинен приділяти достатню частину робочого часу для вивчення та удосконаленняпроцесів стимулювання персоналу. З огляду на всі перераховані вище фактори, слід більш детальнопроаналізувати особливості персональної та групової мотивації сучасних підприємств, види та про-блеми ефективного стимулювання.
Соціальна реклама в Україні: сучасні реалії та перспективи розвитку
Authors: Мунтян І. В. , Євтушок О. В. , Гнатовська Д. О.
Published: July 2020

Для управління соціальними процесами, розповсюдження важливої суспільно-правової інфо-рмації, формування правильної громадської думки та залучення громадян до вирішення актуаль-них проблем соціуму використовуються такий інструмент як соціальна реклама. В статті розкритіосновні проблеми соціальної реклами в Україні, продемонстровані її реалії та вплив на українськесуспільство. Сучасний ринок соціальної реклами в Україні залишається на стадії формування черезвідсутність єдиного керуючого органу, недостатній досвід, низьку інформаційну підтримку та рядінших факторів. Незважаючи на гласність даного питання, демографічні, економічні, політичні тасоціальні проблеми, соціальна реклама не знаходить значимої підтримки з боку державних та ін-ших структур. Незнання особливостей функціонування та розвитку реклами негативно впливає намеханізм вирішення існуючих соціальних проблем в сучасному українському соціумі, що, в своючергу впливає на низьку ефективність управління соціальними процесами. Дані тенденції актуалі-зують необхідність зміни законодавчої бази, що регулює відносини в сфері реклами, підготовки ви-сококваліфікованих фахівців, що займаються розробкою реклами, забезпечення умов посиленнявпливу соціальної реклами на формування високоморальної культури українського суспільства.
Стимулювання творчої праці персоналу як фактор підвищення інвестиційної привабливості підприємств харчової промисловості
Authors: Колесник В. І.
Published: July 2020

Стаття розглядає актуальні питання управління творчою працею, зокрема її стимулювання якфактор підвищення інвестиційної привабливості на підприємствах харчової промисловості. В статтіпроаналізовано сутність творчої праці як категорії управлінської науки, основні ознаки творчої праці, втому числі порівняно до інших видів енергії зхарактеризована духовна енергія як основа та джерелотворчої праці. Визначаються проблеми науки та практики менеджменту відносно стимулювання твор-чої праці, серед яких виокремлено проблеми якості професійної управлінської компетенції, недифере-нційованого підходу до стимулювання творчої праці, проблему системності й науковості в практичнійроботі з персоналом творчої праці. Запропоновано системний підхід до стимулювання творчої праці,який передбачає з одного боку створення сприятливого середовища для генерації духовної енергіїперсоналу, а з іншого –баланс технізації виробництва, мета якого – оптимізація використання різнихтипів енергії (праці) у виробництві.
Інноваційні засади управління системою логістичних бізнес-процесів зернового господарства
Authors: Ніколюк О. В. , Донець Л. Я.
Published: July 2020

В статті здійснено дослідження особливостей управління системою логістичних бізнес-процесів зернового господарства. Удосконалено методичний підхід до формування та реалізації інно-ваційного механізму управління системою логістичних бізнес-процесів зернового господарства, оцінкивпливу логістичної інтеграції на результативність функціонування сільськогосподарських підприємствта реалізації функції контролінгу шляхом використання контрольно-логістичного хронографу субконт-рактних відносин. Визначено, що реалізація запропонованого інноваційного механізму управління сис-темою логістичних бізнес-процесів зернового господарства досягаються за такими організаційно-функціональними напрямами: формуючи координаційні логістичні групи з метою оптимізації логістич-них бізнес-процесів, посилюючи цим самим інтеграційну функцію субконтрактації на рівні галузі, роз-виваючи систему «експорту інновацій» та нейтралізуючи негативні фактори; утворенням координацій-ної ради зернового господарства, яка функціонує на постійній основі та є ініціатором формування ло-гістичних систем, що сприяє фінансовій і законодавчій підтримці, залученню до логістичної системиорганів державної влади, науково-освітніх та фінансових установ, розробці і впровадженню єдиногоінформаційного ресурсу, підтримці логістичної системи на основі шерінг-платформи.
Управлінські аспекти фінансових моделей формування та зростання вартості капіталу підприємства
Authors: Магдалюк О. В.
Published: July 2020

Вартісна проблематика дослідження капіталу підприємства є однією з найбільш популяри-зованих у сучасних фінансово-економічних публікаціях. Це пояснюється тим, що здатність капіта-лу як вартості формувати додану вартість є його іманентною властивістю. Розглядаючи підпри-ємство як форму організації капіталу, науковці та практики фокусуються переважно на йогооб’єктному аспекті, що пов’язаний із дослідженням його вартісних характеристик з точки зорупотенційного об’єкту інтересу для інвесторів. Узагальнюючи результати критичного аналізууправлінських аспектів базових фінансових моделей формування та зростання вартості капіталуможна зробити наступні висновки, що більшість дослідників пов’язують вартість капіталу з фак-торами формування фундаментальної вартості капіталу, а також з процесами забезпечення їїзростання. Визначено, що основними напрямами визначення вартості капіталу є аналітичні фак-торні моделі вартості капіталу, які умовно можна розподілити на моно- та полікритеріальні, які,досліджують пріоритетність одного фактору/аспекту впливу на вартість, та такі що визнача-ють вартість як результат взаємодії певних факторів/аспектів.
Що таке «традиційна» теорія бухгалтерського обліку та чому її критикують?
Authors: Яценко В. Ф.
Published: July 2020

В статті проведений огляд вітчизняної і зарубіжної академічної літератури, проаналізовані кри-тичні зауваження щодо існуючої теорії бухгалтерського обліку вітчизняними науковцями та співставлен-ні з позицією зарубіжних колег. Контент-аналіз терміну «традиційна» у сфері бухгалтерського обліку до-зволив узагальнити підходи до його використання. Зафіксовано значний вплив західних тенденцій нарозвиток поглядів вітчизняних науковців на теорію бухгалтерського обліку. Проведене дослідженняпродемонструвало необхідність врахування особливостей історичного шляху становлення вітчизняноїекономічної системи, яка має суттєвий вплив на розвиток теорії бухгалтерського обліку. Вектор майбут-нього розвитку теорії бухгалтерського обліку як результат подолання критичної маси зауважень дово-дить, що в єдиній обліковій системі окреслюється чітке розмежування двох взаємопов’язаних підсистем:стандартизованого фінансового обліку та управлінського обліку як обліково-аналітичного забезпеченняуправління підприємством.
Громадівський вимір публічного управління в умовах децентралізації влади та управління
Authors: Павлов О. І. , Павлова І. О.
Published: July 2020

У статті обґрунтовано новий підхід до системи публічного управління в Україні, визначено їїструктуру, характеристику суб’єктів публічного управління, вказано джерело та сферу розповсюджен-ня їх владно-управлінських повноважень. Доведено зростаюче значення об’єднаних територіальнихгромад (ОТГ) в управлінні суспільними справами, висвітлено тенденцію переміщенняцентру тяжіння владних повноважень від органів державної влади до інститутів самоврядування.Сформульовано мету дослідження, яка полягає у визначенні сутності громадівського виміру публічно-го управління в умовах децентралізації влади і управління та у виявленні ключової ролі в цьому про-цесі ОТГ. Для її досягнення використано системний підхід, сукупність загальнонаукових та спеціаль-них методів. Наукове та практичне значення дослідження випливає з обґрунтування концептуальнихзасад сучасної системи публічного управління, яка враховує суспільне призначення реформи децент-ралізації влади та управління, розширення владних повноважень ОТГ, їх вплив на майбутній адмініст-ративно-територіальний устрій країни.
Successful Treatment of Patients with Refractory High-Grade Serous Ovarian Cancer withGOPC-ROS1Fusion Using Crizotinib: A Case Report
Authors: Dong Dapeng , Shen Ge , Da Yong , Zhou Ming , Yang Gang , Yuan Mingming , Chen Rongrong
Published: July 2020

Background

Recently, multiple poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated excellent efficacy among patients with ovarian cancer with or without BRCA mutations. However, alternative therapeutic options are urgently required for patients who cannot benefit from conventional chemotherapy or PARP inhibitors.

Case Presentation

A patient with high-grade serous ovarian carcinoma presented to our clinic after developing resistance to chemotherapy. Paired tumor-normal next-generation sequencing (NGS) was performed using peripheral blood to identify potential actionable mutations. NGS revealed the patient harboring a GOPC-ROS1 fusion, which was subsequently verified using a reverse transcription polymerase chain reaction assay. No germline or somatic mutation in BRCA1/2 or mismatch repair genes was detected. Therefore, the patient received crizotinib treatment. A rapid, favorable clinical response (partial response at 1 month) was observed, with further pathological response monitored and evaluated in follow-up interrogation.

Conclusion

This study suggested that crizotinib was an off-the-shelf, practical, and ostensibly effective treatment option for patients with ovarian cancer with ROS1 rearrangement. NGS-based genetic testing may guide to plan therapeutic paradigms, and render precision medicine promising in ovarian cancer treatment.

Implications for Practice

Despite the previous report of ROS1 fusion in patients with ovarian cancer, it remains unknown whether patients can benefit from targeted therapeutic drugs. This study reports a GOPC-ROS1 fusion identified by next-generation sequencing in a patient with chemotherapy-resistant ovarian cancer. The patient was administered crizotinib and showed rapid, remarkable response. This study suggests that comprehensive sequencing should be offered for patients with ovarian cancer without effective therapeutic strategies, and crizotinib can be used to treat ROS1-rearranged ovarian carcinomas.
The Hidden Heterogeneity of Inflation Expectations and its Implications
Authors: Dräger Lena , Lamla Michael J. , Pfajfar Damjan
Published: July 2020

Using a new consumer survey dataset, we document a new dimension of heterogeneity in inflation expectations that has implications for consumption and saving decisions as well as monetary policy transmission. We show that German households with the same inflation expectations differently assess whether the level of expected inflation and of nominal interest rates is appropriate or too high/too low. The `hidden heterogeneity' in expectations stemming from these opinions is related to demographic characteristics and affects current and planned spending in addition to the Euler equation effect of the perceived real interest rate. Furthermore, these differences in opinions affect German households differently depending on whether they are renters or homeowners.
Effectiveness of integrative learning models in improving understanding of mathematical concepts
Authors: SALAM Mohamad , - Jafar , PRAJONO Rahmad
Published: July 2020

Abstract. This study aims to determine the effectiveness of the Integrative Learning model in improving the understanding of mathematical concepts. The integrative learning model is a learning model that aims to help students develop an in-depth understanding of building systematic knowledge that simultaneously trains their critical thinking skills by using a variety of thinking skills. This research is a quasi-experimental design used is Pretest-Posttest Control Group Design. This research was conducted in Senior High School (SHS) 6 Kendari class XI.2 as an experimental class and XI.4 as a control class. The experimental class is taught the integrative learning model, while the control class is taught by the direct learning model. The results of this study are: (1) the average understanding of mathematical concepts of students taught with integrative learning models increased from 60.56 to 77.61 and the average understanding of mathematical concepts of students taught with direct learning models increased from 60.11 to 68.87. (2) integrative and direct learning models are effective in increasing understanding of mathematical concepts, and (3) integrative learning models are more effective in improving understanding of mathematical concepts compared to direct learning models
SARS-CoV-2 detection with ApharSeq v1
Authors: Strauss Daphna , Rahat Ayelet , Sharkia Israa , Chappleboim Alon , Adam Miriam , Kitsberg Daniel , Fialkoff Gavriel , Lotem Matan , Gershon Omer , Schmidtner Anna-Kristina , Oiknine-Djian Esther , Klochendler Agnes , Sadeh Ronen , Dor Yuval , Wolf Dana , Habib Naomi , Friedman Nir
Published: July 2020

The global SARS-CoV-2 pandemic led to a steep increase in the need for viral detection tests worldwide. Most current tests for SARS-CoV-2 are based on RNA extraction followed by quantitative reverse-transcription PCR assays that involve a separate RNA extraction and qPCR reaction for each sample with a fixed cost and reaction time. While automation and improved logistics can increase the capacity of these tests, they cannot exceed this lower bound dictated by one extraction and reaction per sample. Multiplexed next generation sequencing (NGS) assays provide a dramatic increase in throughput, and hold the promise of richer information on viral strains and host immune response. Here, we establish a significant improvement of existing RNA-seq detection protocols. Our workflow, ApharSeq (Amplicon Pooling by Hybridization And RNA-Seq), includes a fast and cheap RNA capture step, that is coupled to barcoding of individual samples, followed by sample-pooling prior to the reverse transcription, PCR and massively parallel sequencing. Thus, only one step is performed before pooling hundreds of barcoded samples for subsequent steps and further analysis. Considering these improvements, our proposed workflow is estimated to reduce costs by 10-50 fold, labor by 5-100 fold, automated liquid handling by 5-10 fold, and reagent requirements by 100-1000 fold compared to existing methods.
2XYT Medium (Version 2-0) Haseloff Lab v1
Authors: FGC Guzman Chavez Fernando
Published: July 2020

Work instruction for 2xYT and 2xYTG medium preparation Following this recipe, you will obtain 1L of 2XYT medium 2X YTis a standard growth medium used to cultivateE. coli. In cell-free system, this medium is commonly used to growth the cells. NOTE : The protocol described here is an adaptation from these papers: Adam D. Silverman, Nancy Kelley-Loughnane, Julius B. Lucks, and Michael C. Jewett (2019).Deconstructing Cell-Free Extract Preparation for in Vitro Activation of Transcriptional Genetic Circuitry. ACS Synthetic Biology, 403-414. DOI: 10.1021/acssynbio.8b00430. Andriy Didovyk, Taishi Tonooka, Lev Tsimring, and Jeff Hasty. (2017).Rapid and Scalable Preparation of Bacterial Lysates for Cell-Free Gene Expression. ACS Synthetic Biology, 2198-2208. DOI: 10.1021/acssynbio.7b00253.
Operative Invariants of Algebraic Pattern Present in the Strategies of Students of the 3rd Grade of Elementary School
Authors: Beck Vinicius Carvalho , Silva João Alberto Da
Published: July 2020

Background: One of the great challenges for mathematics education in the 21st century is to alleviate the difficulties of students in the transition from arithmetic to algebra. There is already a consensus that there should not be a transition, as several experts have indicated algebraic approaches since the early years of schooling. Objectives: This study aims to describe and analyze the operative invariants of algebraic patterns present in the strategies of students of the 3rd grade of an elementary public school in the countryside of the state of Rio Grande do Sul. Design: The methodology used in this research was the clinical method of manipulation-formalization, created by Jean Piaget and applied in several of his studies. Setting and Participants: Students of the 3rd grade. Data collection and analysis: Clinical interviews. Results: We start from the assumptions of Gerard Vergnaud's theory of conceptual fields to analyze the strategies used by the research participants. Conclusions: We identified four operative invariants: the theorems-in-action "count the places each time a table is introduced" and "add two places each time a table is introduced", respectively linked with the concepts-in-action "putting the tables together" and "place at the ends of the tables".
Intelligent Wireless Surveillance of Multirate Induction Motors
Authors: Nouby M.
Published: July 2020

Recent advances in the automation field provide a wide range of scope in control and monitoring of the industrial systems. A very accurate automation system is on high demand in recent times. This paper mainly deals about remote monitoring and control of the induction motor. The main objective is to develop an embedded system to prevent the occurrence of line fault in a three phase system (say induction motor) and to display and control the parameters voltage, speed and temperature of the three phase system using Zig-bee communication technology. An ARM microcontroller is used in this project, which controls the entire operation of the system, which also communicates various parameters from one part of the system to other through Zig-bee technology. To prevent the issues of poor blunder elements and commotion affectability emerging in functional applications, the plan issue is changed into a proportional Linear Matrix Inequality (LMI) structure to understand a vigorous state criticism roughly by quick yield testing .The control objective is encircled with rise time, overshoot and settling time particulars. Subsequent to arriving at the consistent express the controller ought to look after solidness. To fulfill the above prerequisites a quick yield inspecting control calculation is planned with the end goal that the ideal shut circle conduct and shut circle soundness is accomplished. The exhibition of the framework is broke down for controlling the speed through wireless networks.
Identification of Hemorrhages in Iris Using Hybrid Morphological Method
Authors: Rahim Robbi
Published: July 2020

In the field of ophthalmology, hemorrhage is the term used more often because of increasing diabetic patients. It’s a challenge amidst the ophthalmologist to distinguish the hemorrhage from the blood vessels, these lands in various problems. In the past various techniques were employed for the detection of the hemorrhage but they were not so accurate and often encountered misclassification between hemorrhage and blood vessels. Precise detection and classification of hemorrhage and blood vessel is very important in the diagnosis of many problems. This paper depicts a mechanized procedure for recognizing hemorrhages in fundus pictures. The acknowledgment of hemorrhages is one of the critical factors in the early finish of diabetic retinopathy. The algorithm proceeds through several steps such as image enhancement, image subtraction, morphological operations such as image thresholding, image strengthening, image thinning, erosion, morphological closing, image complement to suppress blood vessels and to highlight the hemorrhages
Algorithms in Finding All the 4 by 4 Magic Matrices
Authors: Chen Zheng
Published: July 2020

In this paper, based on the Gauss-Jordan elimination to solve linear systems,  the algorithms for finding all the magic matrices of size 4 by 4 are developed and discussed, and the efficiency of the algorithms is tested after complementing the algorithms in MATLAB. The total magic matrices of 4 by 4 can be found with the program; for completeness and explaining the algorithms, the case of 3 by 3 is also included.
An IoT based Game Controlling Device (JoyGlove)
Authors: Rana Harsh Ganpatbhai , Soni Aayushi Sanjay
Published: July 2020

Nowadays, there is a huge inclination of youngsters and adults towards video games and of course in our childhood everyone might definitely have experienced it. However, we are controlling the game using typical input devices such as mouse, keyboard, joystick, etc but how about, if we control the game using our hand gestures ? These days we have lots of game controllers that are surpassing the gaming experience however they are quite expensive too. Through this project we have designed our own game controlling glove using Arduino. In addition we have also developed a car game using UNITY 3D. The areas of IOT and hand gesture recognition will be explored by this project.
Face Recognition for Payment and Information Sharing
Authors: Singh Siddharth , Bangalore Shivani , S Amutha , Girish Anupama
Published: July 2020

We have seen the emergence of various payment and information sharing methods with the rapid digitization of such services. Payment methods like NFC, Credit/Debit card, and QR code-based have become very common. These methods were intended to provide secure, safe and faster transactions. Although these have succeeded in their intentions up to some extent, there are various factors that are posing problems like confusion, time consumption, security threat, fraud, and theft. When it comes to sharing contact information and social media handles, visiting cards are still preferred but this is not the most reliable method as one either tends to lose these cards or has to store this information manually on their phone. This paper provides a comprehensive survey of the various available methods for making mobile payments and sending contact details as well as the challenges faced. Furthermore, we discuss and compare alternative available technologies like face recognition that can be implemented.
Internet of Things based Driver Exhaustion Detection System using Distributed Sensor Network
Authors: Rahim Robbi
Published: July 2020

Accidents involving vehicles occur almost every day. Most of the accidents are caused due to exhaustion of driver’s consciousness but this cause goes almost unreported due to the absence of systems to detect the fatigue. Techniques to measure driver fatigue can be invasive or non-invasive. All in all, driver-related information uncover a more grounded relationship to the driver's carefulness level than vehicle-related ones, which experience the ill effects of a bigger affectability to outer parameters, for example, street and traffic conditions. A measure of the amount of grip that the driver applies on the steering wheel is a more direct and non-invasive measure of his fatigue. An alcohol sensor when added to this system can further be used to check if the variation in grip is due to the effect of alcohol. A suitable algorithm is developed to confirm the occurrence of driver fatigue. The GSM and the GPS units attached to the system can be useful in notifying the control room in the event of driver fatigue. This project can be very useful in detecting fatigues in drivers associated with vehicle fleets using IoT.
Experience with women having uterine cancer in Eastern India: a hospital based study
Authors: Singh Priyanka , Ray Chandrima , Mandal Ranajit
Published: July 2020

Background: The changing lifestyle has led to a rise in obesity, diabetes and hypertension in India which the most important risk factors for developing uterine cancer. The treatment of uterine cancer is evolving and requires proper evaluation and often adjuvant treatment for better survival. The disease being associated with symptoms of abnormal uterine bleeding often ends up being inadequately managed by non-oncologists practicing in a generalist setting in India. The current study was aimed to audit and observe any difference in outcome of patients primarily treated in the oncology set-up of the Chittaranjan National Cancer Institute, which is a regional cancer center in India versus those receiving primary treatment in a non-oncological set-up.Methods: Retrospective data was collected from hospital records after setting inclusion and exclusion criteria for the study.Results: There is poor correlation between the endometrial biopsy and histopathology findings of patients operated in non-oncological setting as compared to that in the institute. The overall survival of patients operated in the institute was superior to those treated outside.Conclusions: Patients having risk factors and symptoms akin to that of uterine carcinoma must be treated in an oncological set-up ideally.
A study of hypertensive disorders of pregnancy and the fetal outcome in a tertiary care hospital: a prospective study
Authors: Mathapati Sangamesh S. , Biradar Aruna M. , Sangolli Laxmi S. , Mangalwadi Nidhi A. , S. Gamini B. , S. Sridevi H.
Published: July 2020

Background: Pregnancy induced hypertension is one of the major causes of feto maternal morbidity and mortality in pregnancy. The exact cause of PIH is unknown certain factors are known to increase the risk of PIH such as risk factor includes that young women with first pregnancy.Methods: The objective of this study was to assess the socio-demographic and clinico-pathological profile of the patients with hypertensive disorders of pregnancy and its associated fetal outcomes. A prospective study was conducted in department of obstetrics and gynecology Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura Karnataka from 15th July to 15th December 2018. All women admitted to labour ward with diagnosis of hypertensive disorders of pregnancy were included in the study after ruling out the exclusion criteria and thorough history, examination and laboratory evaluation were done and followed till delivery.Results: A total of 123 pregnant women with hypertensive disorder of pregnancy were enrolled in the study. Most of the participants were in the age group of 20 to 30 years. The PIH was seen mostly in primigravida, lower socioeconomic status and with lower educational levels. Emergency LSCS is the most common mode of delivery.Conclusions: The hypertensive disorder in pregnancy affects the majorly younger age group. It is most commonly seen in low socio-economic and uneducated population. Hence, there should be provided with proper antenatal care, early detection of hypertensive disorders for better feto-maternal outcome.
Advanced cervical leiomyosarcoma with severe comorbidities: a clinical conundrum for optimal management
Authors: Dubey Pankhuri , Gadre Sandhya
Published: July 2020

Leiomyosarcoma of uterine cervix constitute a very rare but aggressive group of neoplasms of the cervix with poor prognosis. Although recognised as a distinct entity, treatment algorithms and overall management strategies rely on suggestions from uterine counterparts as robust data on management of the cervical leiomyosarcoma, especially when advanced, is scarce. Present case was a 51-year-old perimenopausal woman with acyclic vaginal bleeding and dyspnoea on ordinary physical activity. On examining, a firm hypogastric mass of 14 weeks was found abdominally and a pedunculated, polypoidal hard mass of 5X5 cm with a 2 cm thick peduncle coming out of endocervical canal (confirmed on CT) was noted hanging outside vagina. Histopathology suggested cervical leiomyosarcoma. Triple vessel disease and severe cardiac dysfunction (LVEF=30%) with large left ventricular thrombus rendered the patient at very high risk for mortality during surgery. Systematic comorbidity assessment with due consideration to risk-benefit ratio of all treatment options was undertaken and neoadjuvant chemotherapy was started after multidisciplinary recommendation. Patient tolerated the first cycle of chemotherapy well but died of a sudden cardiac arrest after one week. Advanced age and stage are poor predictors for survival in patients with aggressive cervical leiomyosarcomas, even more so, in those with severe comorbidities. Meticulous clinical evaluation and systematic incorporation of comorbidity indices in decision-making for tailored cancer treatment is imperative in arriving at a justified plan of action for this rare and aggressive entity.
Evaluation of clinical profile, radiological and functional outcome following anterior cervical discectomy and fusion for cervical compressive myelopathy
Authors: Kumar Ranjit , Tiwari Brijesh Kumar , Pandey Sanjeev Kumar
Published: July 2020

Background: Symptomatic cervical disc prolapse is best managed with anterior cervical discectomy with or without fusion. We studied the clinical, radiological and surgical profile with postoperative outcome of the patients undergoing anterior cervical discectomy and fusion (ACDF) for cervical compressive myelopathy at one level.Methods: In this retrospective study, data was collected from patients who underwent ACDF for cervical compressive myelopathy in our hospital between 2016 and 2019. Clinical, radiological profile with surgical outcome were studied.Results: A total of 283 patients were recruited. They could be followed up for a period of at least 6 months and so were recruited for the study. Out of these 283 patients (201 males; 82 females; mean age, 48.4 years, range, 22 years to 83 years), magnetic resonance imaging (MRI) cervical spine without contrast and x-ray cervical spine was available for all the patients. Nape of neck pain was the most common presenting symptom followed by tingling sensation in all four limbs and trunk. Average time taken for surgery was 2 hours 10 minutes with an average blood loss of 50 ml. Mean follow up duration was 2.7 years (range 6 months to 4 years).Conclusions: ACDF is the treatment of choice for the patients with clinical and radiological evidence of cervical cord compression. The techniques is associated with minimal blood loss and exceptionally good surgical outcome. Following discectomy, putting an autologous graft or titanium cage improves the spine stability and maintains the cervical lordosis.
A 12 weeks, randomized and double-blind evaluation of the efficacy of oral supplements of probiotics (Lactogut and Lactogut Kidz) on atopic dermatitis in adults and children
Authors: Chandrashekar B. S. , Agarwal Rashmi , Nayak Preethi B. , Vijayraghavan S. , Deshmukh Atul A.
Published: July 2020

Background: The primary objective of the study was to evaluate the efficacy and safety of oral probiotics in the treatment of atopic dermatitis (AD) using the scoring atopic dermatitis (SCORAD) index, serum IgE levels and absolute eosinophil count (AEC). The secondary objective of the study was to determine the association of oral probiotic therapy and improvement in AD using global photographs, dermoscopic images (fotofinder) and individual patient satisfaction.

Methods: This was a randomized, double-blind study conducted on 70 patients (20 adults and 50 children) with moderate to severe AD. The participants were randomized into control arm and treatment arm. The treatment arm received conventional and probiotic therapy and only conventional therapy was provided to the control arm. The research was carried out in five visits. For each visit, SCORAD was calculated and response compared using clinical and videodermoscopic images. Patient satisfaction was documented using a quality of life questionnaire during each visit.

Results: Across the treatment arm, the mean serum IgE levels were greatly decreased in contrast to the control arm over the 12 weeks period. SCORAD score was significantly lowered in the treatment arm (55.20%) compared with 18.95% in the control arm. Dermoscopic assessment, global photographic assessment and patient satisfaction in the treatment arm showed statistically significant improvement in AD compared to the control arm.

Conclusions: The decrease in SCORAD scores demonstrated strong associations with the use of probiotics in patients with AD as an adjunct to conventional therapy. Thus, in both adults and children suffering from moderate to severe AD, probiotic supplement can be administered effectively as an adjunct therapy.

 
Desarrollo de la Escala de Síntomas Internalizados en la Primera Infancia (ESIPI)
Authors: Romero-Acosta Kelly , García-Manjarrés Judith Elena , Doria-Dávila Daniela , Ruíz Federico Armando
Published: July 2020

El objetivo del presente estudio es diseñar una escala que alerte sobre los problemas emocionales en niños de dos a cincoaños a partir del análisis del discurso de agentes educativos y madres comunitarias, en el departamento del Atlántico. Elestudio es de corte cualitativo, e incluye diseño de análisis del discurso. Los participantes fueron 35 individuos de edadescomprendidas entre 18 y 56 años, principalmente de nivel socioeconómico medio-bajo. La muestra se dividió en dos gruposfocales, quienes contestaron una encuesta, participaron en un taller y colaboraron con tres entrevistas a profundidadsobre su experiencia en los centros de desarrollo infantil y hogares comunitarios. El resultado del estudio fue la creaciónde la Escala de Síntomas Internalizantes en Primera Infancia (ESIPI), la cual contiene tres subescalas: ansiedad, síntomasdepresivos y síntomas somáticos.
Leveraging the Covid-19 Crisis in Making Work-From-Home a Mainstream Practice in the Oil and Gas Industry
Authors: Dewi Indira , Adiarsi Gracia Rachmi
Published: July 2020

During the COVID-19 crisis, the oil and gas industry is among industries that face challenges in selling their products and struggling to manage their cash flow. The pressure to improve financial discipline within the oil and gas industry started even before the COVID-19 crisis. This paper validates the feasibility of adopting work-from-home (WFH) as a permanent practice for oil and gas companies in Indonesia and how it will help to reduce costs, enhance employee productivity, and improve their organizational agility. The survey was conducted two weeks after the start of the forced WFH “experiment.” One hundred nine executives from various oil and gas companies in Indonesia took part in the survey. The result of this study resulted in most of the large and established companies in Indonesia, in particular, the oil and gas companies, being slow in adopting this practice. The COVID-19 crisis could be the turning point for a wider and lasting adoption of WFH in the oil and gas industry. The survey results validate that business can still run even when their employees are working from home. Also, the survey results showed that a shift of opinion toward accepting WFH as the new normal exists. The survey indicates that many companies have crossed psychological and mental blocks and are receptive to the idea of making WFH part of normal HR practices.
A Sensitive Aptamer-Based Biosensor for Electrochemical Quantification of PSA as a Specific Diagnostic Marker of Prostate Cancer
Authors: Hassani Shokoufeh , Salek Maghsoudi Armin , Rezaei Akmal Milad , Rahmani Soheila Rahmani , Sarihi Pouria , Ganjali Mohammad Reza , Norouzi Parviz , Abdollahi Mohammad
Published: July 2020

Purpose: The current project aimed to design a simple, highly sensitive, and economical label-free electrochemical aptasensor for determination of prostate-specific antigen (PSA), as the gold standard biomarker for prostate cancer diagnosis. The aptasensor was set up using a screen-printed carbon electrode (SPCE) modified by gold nanoparticles (Au NPs) conjugated to thiolated aptamers. Methods: Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were implemented for electrochemical (EC) characterization of the aptasensor. The determination of PSA was also performed through differential pulse voltammetry (DPV) in [Fe (CN) 6]3-/4- electrolyte solution. Results: The present aptasensor was shown an outstanding linear response in the concentration range of 1 pg/mL - 200 ng/mL with a remarkably lower limit of detection of 0.077 pg/mL. The optimum concentration for PSA separation and the optimum incubation time for antigen-aptamer binding were determined by observing and electing the highest electrochemical responses in a specified time or concentration. Conclusion: According to the results of the specificity tests, the designed aptasensor did not show any significant interactions with other analytes in real samples. Clinical functionality of the aptasensor was appraised in serum samples of healthy individuals and patients examining the PSA level through the fabricated aptasensor and the reference methods. Both methods are comparable in sensitivity. The present fabricated PSA aptasensor with substantial characteristics of ultra-sensitivity and cost-effectiveness can be conventionally built and used for the routine check-up of the men for prostate problems.
Reflections on the Cluster Epidemic of COVID-19; Lessons Learned from Wuhan’s Experience: A Brief Review
Authors: ZHOU Quan , HUANG Sufang , XIAO Yaru , LI Miqi , GUO Zhiran
Published: July 2020

At present, new coronavirus pneumonia (COVID-19) is circulating worldwide. The pathogen of this coronavirus pneumonia is named SARS-CoV-2. The virus has a long incubation period and is highly contagious. There is currently no specific targeted drug treatment. The focus of anti-epidemic work should be more on prevention and control while cutting off the virus transmission route while treating infected patients, and protecting healthy people. In order to protect the safety and health of the Chinese citizens and to maintain the safety of world public health, the Chinese government and people have made unprecedented efforts to control the epidemic. Many people in the international community have joined in limiting the spread of COVID-19. This article combines the development of COVID-19 epidemic situation in Wuhan, the relevant prevention and control measures of the Wuhan government and local health authorities to share Wuhan’s experience on control the cluster epidemic and provide new suggestions and ideas for epidemic prevention and control.
An Introduction to SARS Coronavirus 2; Comparative Analysis with MERS and SARS Coronaviruses: A Brief Review
Authors: TAHERIZADEH Mahsa , TABIBZADEH Alireza , PANAHI Mahshid , SAFARNEZHAD TAMESHKEL Fahimeh , GOLAHDOOZ Mahsa , KARBALAIE NIYA Mohammad Hadi
Published: July 2020

Since the 1970 the replication and pathogenesis mechanism of different coronaviruses have been studded.. In 2002-2003, SARS (Severe Acute Respiratory Syndrome coronavirus) in China emerged which resulted in 8098 cases and 774 deaths. About 10 years later in 2012, the MERS (Middle East Respiratory Syndrome coronavirus) spread in Middle Eastern countries and leads to infection in 2465 cases. In Dec 2019, another acute respiratory disease caused by a novel coronavirus named SARS-2 emerged in Wuhan, China. The virus is assumed to be mainly transmitted by respiratory droplets. Travels and communications leads to high prevalence of COVID-19 (Coronavirus Disease 2019) in the world, and currently in Iran. The current review was conducted to compare the virus structure, genome organization, virus life cycle, pathogenesis and prediction the future of COVID-19.
Obstetrics and Neonatal Outcomes in Pregnant Women with COVID-19: A Systematic Review
Authors: BANAEI Mojdeh , GHASEMI Vida , SAEI GHARE NAZ Marzieh , KIANI Zahra , RASHIDI-FAKARI Farzaneh , BANAEI Sedigheh , MOHAMMAD SOURI Behzad , ROKNI Mohsen
Published: July 2020

Background: Considering that the obstetricians and pediatricians need to comprehensive information about the obstetric and neonatal effect of COVID-19, this review study was conducted to investigate the impact of COVID-19 on obstetrics and neonatal outcomes.
Methods: In this systematic review the international search databases following PubMed, Web of Science, Scopus, ProQuest and Embase and Google scholar were searched. All articles were reviewed by two independent researchers until 10 April 2020. After quality assessment of included studies the finding reported in 2 sections obstetrics and neonatal outcomes.
Results: The sixteen studies with a sample size of 123 pregnant women with a definitive diagnosis of COVID-19 and their neonates were evaluated. The range of gestational age was 25-40 weeks. There was no death associated with COVID-19 in pregnant women. The obstetric outcomes in pregnant women with COVID-19 include decreased fetal movement, intrauterine fetal distress, anemia, PROM, preterm labor, Multiple Organ Dysfunction Syndrome (MODS) and etc. The most common delivery mode in women affect with COVID-19 was cesarean section. Expect for one case with MODS, in the majority of the studies reviewed, no severe morbidity or mortality occurred. The neonatal outcomes were stillbirth, prematurity, asphyxia, fetal distress, low birth weight, small for gestational age, large for gestational age, multiple organ dysfunction syndrome, disseminated intravascular coagulation and neonatal death. In addition, five neonates born to mothers with COVID-19 were positive for SARS-CoV-2. However, the studies report these outcomes but the exact causes of theme are not known.
Conclusion: In this systematic review, we summarize the diverse results of studies about the obstetrics and neonatal outcomes following COVID-19. This infection may cause negative outcomes in both mothers and neonates. However, there were evidence about neonate infected with COVID-19, but there is controversial information about the vertical transmission of COVID-19.
The First Few Hundred Cases for Coronavirus Disease 2019 (COVID-19) in Colombia
Authors: PORRAS-VILLAMIL Julián Felipe , OLIVERA Mario Javier , RÍOS-CAMARGO Nadia Katherine
Published: July 2020

Background: SARS-CoV-2 virus is the causative agent of COVID-19 disease. It is essential to understand the epidemiological characteristics of the first few cases in each country. This study aimed to describe the geographical distribution, and temporal appearance of the first few hundred cases in Colombia.
Methods: This observational study was conducted to review the literature and key documentary information from public health institutions, websites and news reports were examined.
Results: The first few 100 cases for COVID-19 were confirmed in Colombia. According to sex, men with 54% predominate, the most affected age group was 20 to 29 yr old (26%), 9% of the cases required hospitalization and no deaths were reported. Most of the confirmed subjects were from the departments of Cundinamarca. To date, most cases are imported (63%), especially from Spain.
Conclusion: The COVID-19 pandemic puts in evidence the lack of understanding, prevention and contention power of the different countries around the world is not as good as it could be. Politics must not affect the different proposed measures.