bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression, purification, and characterisation of the p53 binding domain of Retinoblastoma binding protein 6 (RBBP6)
Authors: Russell Bonnie L. , Ntwasa Monde
Published: February 2023

RBBP6 is a 250 kDa eukaryotic protein known to be a negative regulator of p53 and essential for embryonic development. Furthermore, RBBP6 is a critical element in carcinogenesis and has been identified as a potential biomarker for certain cancers. RBBP6’s ability to interact with p53 and cause its degradation makes it a potential drug target in cancer therapy. Therefore, a better understating of the p53 binding domain of RBBP6 is needed. This study presents a three-part purification protocol for the polyhistidine-tagged p53 binding domain of RBBP6, expressed in Escherichia coli bacterial cells. The purified recombinant domain was shown to have structure and is functional as it could bind endogenous p53. We characterized it using clear native PAGE and far-UV CD and found that it exists in a single form, most likely monomer. We predict that its secondary structure is predominantly random coil with 19% alpha-helices, 9% beta-strand and 14% turns. When we exposed the recombinant domain to increasing temperature or known denaturants, our investigation suggested that the domain undergoes relatively small structural changes, especially with increased temperature. Moreover, we notice a high percentage recovery after returning the domain close to starting conditions. The outcome of this study is a pure, stable, and functional recombinant RBBP6-p53BD that is primarily intrinsically disordered.
Tinea capitis among schoolchildren in Ethiopia: A systematic review and meta analysis
Authors: Birhanu Molla Yigzaw , Temesgen Habtamu , ketema Daniel Bekele , Desta Melaku , Getaneh Temesgen , Bekele Getamesay Molla , Zeleke Balew , Jemberie Selamawit Shita
Published: February 2023

Background

Tinea capitis accounts for25 to 30% of all fungal infections, but it is often ignored because it is not life threatening in nature. It is more common among schoolchildren particularly in developing countries. Due to the presence of significant variability among the previous studies, this study was conducted to provide a pooled prevalence and associated factors of tinea capitis in Ethiopian schoolchildren.

Method

We conducted a systematic search in five major databases for articles similar to our topic. This review included school-based cross-sectional studies that were reported in English and conducted from 2006 through 2022. The data were extracted using Microsoft Excel and further analysis was done using StataTMVersion 17.0 statistical software. Forest plots were used to assess the presence of heterogeneity with 95% confidence intervals. A random effects meta- analysis model was used to pool primary estimates. To declare the presence or absence of association, 95% confidence interval with odds ratio was used.

Results

Fourteen studies with a total of 9465 schoolchildren were included. The pooled prevalence was 29.03% (95%CI: 15.37–42.71). There was observed heterogeneity, which could be explained by publication bias (P = 0.04). Family history of tinea capitis (OR: 9.18, 95%CI: 3.5–24.02), under the age of 10 years (OR: 1.65, 95%CI: 1.17–2.33) were factors increasing the development of tinea capitis among schoolchildren and schoolchildren who had hair wash at least once a week (OR: 0.31, 95%CI: 0.24–0.42) was significantly associated with reduced risk for tinea capitis.

Conclusion

One of the most prevalent childhood health condition in Ethiopia is tinea capitis, which affects over one in every four schoolchildren. Schoolchildren who had family history of tinea capitis and under the age of 10 years were the identified risk factors but they had hair wash at least once a week was the protective factor of tinea capitis among schoolchildren. Clinical and public engagement activities are needed to overcome the burden of the disease.
A novel assay for improved detection of sputum periostin in patients with asthma
Authors: Ono Junya , Takai Masayuki , Kamei Ayami , Ohta Shoichiro , Nair Parameswaran , Izuhara Kenji , Dahlén Sven-Erik , James Anna ,   on behalf of the BIOAIR consortium
Published: February 2023

Background

Serum periostin associates with type-2 inflammation in asthmatic airways, but also reflects whole body periostin levels originating from multiple sources. Less is known about sputum periostin as a biomarker in asthma as detection levels are low using currently available periostin assays. We aimed to investigate detection of sputum periostin using ELISA assays targeting different periostin epitopes and relate levels to clinical characteristics.

Methods

Two ELISA systems were developed using antibodies detecting whole periostin or cleavage products, the molecular weight and amino acid sequences of which were confirmed. The ELISA assays were applied to sputum from 80 patients with mild-to-moderate and severe asthma enrolled in the European, multi-center study BIOAIR. Results were related to clinical characteristics.

Results

Sputum was found to contain smaller periostin fragments, possibly due to proteolytic cleavage at a C-terminal site. Comparing ELISA methodology using antibodies against cleaved versus whole periostin revealed detectable levels in 90% versus 44% of sputum samples respectively. Sputum periostin showed associations with blood and sputum eosinophils. Furthermore, sputum, but not serum, periostin correlated with reduced lung function and sputum IL-13 and was reduced by oral corticosteroid treatment.

Conclusions

We present an ELISA method for improved analysis of sputum periostin by detecting cleavage products of the periostin protein. Using this assay, sputum periostin was detectable and associated with more disease-relevant parameters in asthma than serum periostin. Sputum periostin is worth considering as a phenotype-specific biomarker in asthma as its proximity to the airways may eliminate some of the confounding factors known to affect serum periostin.
A qualitative study of behavioral and social drivers of COVID-19 vaccine confidence and uptake among unvaccinated Americans in the US April-May 2021
Authors: Abad Neetu , Messinger Seth D. , Huang Qian , Hendrich Megan A. , Johanson Nataly , Fisun Helen , Lewis Zachary , Wilhelm Elisabeth , Baack Brittney , Bonner Kimberly E. , Kobau Rosemarie , Brewer Noel T.
Published: February 2023

Introduction

Around one-third of Americans reported they were unwilling to get a COVID-19 vaccine in April 2021. This focus group study aimed to provide insights on the factors contributing to unvaccinated adults’ hesitancy or refusal to get vaccinated with COVID-19 vaccines.

Method

Ipsos recruited 59 unvaccinated US adults who were vaccine hesitant (i.e., conflicted about or opposed to receiving a COVID-19 vaccination) using the Ipsos KnowledgePanel. Trained facilitators led a total of 10 focus groups via video-conference in March and April 2021. Two coders manually coded the data from each group using a coding frame based on the focus group discussion guide. The coding team collaborated in analyzing the data for key themes.

Results

Data analysis of transcripts from the focus groups illuminated four main themes associated with COVID-19 vaccine hesitancy: lack of trust in experts and institutions; concern about the safety of COVID-19 vaccines; resistance towards prescriptive guidance and restrictions; and, despite personal reluctance or unwillingness to get vaccinated, acceptance of others getting vaccinated.

Discussion

Vaccine confidence communication strategies should address individual concerns, describe the benefits of COVID-19 vaccination, and highlight evolving science using factural and neutral presentations of information to foster trust.
Gaining metabolic insight in older men undergoing androgen deprivation therapy for prostate cancer (the ADT & Metabolism Study): Protocol of a longitudinal, observational, cohort study
Authors: Braga-Basaria Milena , Travison Thomas G. , Taplin Mary-Ellen , Lin Alexander , Dufour Alyssa B. , Habtemariam Daniel , Nguyen Paul L. , Kibel Adam S. , Ravi Praful , Bearup Richelle , Kackley Hannah , Kafel Hussein , Reid Kieran , Storer Thomas , Simonson Donald C. , McDonnell Marie , Basaria Shehzad
Published: February 2023

Androgen deprivation therapy (ADT), a cornerstone of treatment for patients with locally advanced and metastatic prostate cancer, is associated with many adverse effects, including osteoporosis, sexual dysfunction, fatigue, and vasomotor symptoms. It is also associated with loss of muscle mass and increased adiposity. This change in body composition is likely the inciting event in the development of insulin resistance, an independent risk factor for diabetes mellitus and cardiovascular disease. Although the occurrence of insulin resistance during ADT has been reported, it remains unclear whether this insulin resistance is primarily hepatic or muscular. Similarly, the mechanisms that lead to insulin resistance also remain unknown. The ADT & Metabolism Study was designed to address these knowledge gaps, as the elucidation of the predominant site of insulin resistance will allow prevention strategies and the use of targeted, tissue-specific insulin-sensitizing agents in patients undergoing ADT. This prospective, mechanistic, single-center, 24-week, observational cohort study will enroll treatment-naïve adult men with prostate cancer about to undergo surgical or medical ADT for at least 24 weeks (ADT group; n = 50) and a control group of men who had undergone radical prostatectomy and are in remission (non-ADT group, n = 25). The primary outcome is to determine the site of insulin resistance (skeletal muscle or liver) using frequent sampling oral glucose tolerance test at baseline and 12 and 24 weeks after commencement of ADT (ADT group) or after enrollment in the study (non-ADT group). Secondary outcomes will assess changes in hepatic and intramyocellular fat (using magnetic resonance spectroscopy), inflammatory markers, adipokines, free fatty acids, and changes in body composition (assessed using dual-energy x-ray absorptiometry) and their correlation with the development of insulin resistance. Exploratory outcomes will include changes in muscle performance, physical function, physical activity, vitality, and sexual drive.
Gastroscopy after positive screening for faecal immunochemical tests and colonoscopy: A systematic review
Authors: Choe Lina , Lau Jerrald , Yip Larry Teck-Seng , Kim Guowei , Tan Ker-Kan
Published: February 2023

Background

Colorectal cancer (CRC) screening using the faecal immunochemical test (FIT) kits based on the detection of occult blood in stool is widely advocated in numerous screening programs worldwide. However, CRC is not commonly diagnosed in positive cases. We undertook this review to determine if there is evidence to suggest the use of opportunistic oesophago-gastro-duodenoscopy (OGD) in patients without CRC.

Methods

A systematic review encompassing three electronic databases was performed. All peer-reviewed studies of FIT-positive patients who underwent either OGD and colonoscopy concurrently or OGD post-colonoscopy were included. Only studies from 2008 to 2022 using FIT kits were included to ensure studies not previously included in an earlier review were being analysed. A forward citation search of the included articles was also conducted to ensure no relevant articles were missed.

Results

A total of 2409 records were extracted. Only four studies fulfilled the selection criteria and were included. Although the rates of abnormal OGD results were relatively high in the four studies, only 3 of 605 (0.50%) patients had gastric cancer in the entire review sample. No other malignancies were identified in all four studies. Other notable pathologies such as gastric polyps and gastritis were also reported.

Conclusions

There is little overall evidence to recommend UGI screening for all FIT-positive patients following a colonoscopy. However, there may be a role for clinicians to consider opportunistic OGD in this group of patients. Future research should examine patient populations from other sociocultural contexts including cost-effective analysis when considering changes in health guidelines on UGI screening.
Relationship between ultra-widefield optical coherence tomography and ophthalmoscopy for detecting posterior inflammation in posterior uveitis and panuveitis
Authors: Misawa Norihiko , Tagami Mizuki , Sakai Atsushi , Haruna Yusuke , Honda Shigeru
Published: February 2023

Purpose

To confirm the utility of ultra-widefield optical coherence tomography (W-OCT) for diagnosing uveitis.

Method

We retrospectively studied patients who had been diagnosed with uveitis and had undergone W-OCT. All patients had visited at Osaka Metropolitan University between January 2019 and January 2022. On W-OCT, vitreous opacity (“W-OCT VO”) and the presence of vitreous cells (“W-OCT Cells”) were identified by three specialists. We compared findings from ophthalmoscopy (“Ophthalmoscopic findings”) and fluorescein angiography (“FAG findings”) with those from W-OCT.

Results

This study investigated 132 eyes from 68 patients (34 males, 34 females; mean age, 53.97±22.71 years). Vitreous cells in posterior uveitis and panuveitis differed significantly between “W-OCT Cells” and “Ophthalmoscopic findings” for all cases (P = 0.00014). Vitreous opacities in posterior uveitis and panuveitis did not differ significantly between “W-OCT VO” and “Ophthalmoscopic findings” (P = 0.144) for all cases. Compared to “Ophthalmoscopic findings”, “W-OCT Cells” offered 51.1% sensitivity and 66.7% specificity for all cases (p<0.01). Compared to “Ophthalmoscopic findings”, “W-OCT VO” offered 78.6% sensitivity and 30% specificity for all cases (p = 0.19). In addition, “W-OCT Cells” did not differ significantly from “FAG findings” for all cases (P = 0.424).

Conclusion

W-OCT was shown to offer significantly greater sensitivity than ophthalmoscopy for detecting vitreous cells. The results of this study may add an option for the evaluation of uveitis.
ソマティック実践とダンスの小史：ソマティック・エデュケーションの歴史的展開とダンスとの関係1
Authors:   マーサ・エディ, Eddy Martha ,   翻訳：村越直子,   橋本有子,   翻訳編集者：ディエゴ・ピサロ, Murakoshi Naoko , Hashimoto Yuko
Published: February 2023

本稿は、ソマティック・ムーヴメント実践の歴史的発展について、特にダンス、ダンサー、そしてダンス教育機関に関わる事柄を概説する。

はじめに、20世紀の転換期に「古典的な」ソマティック技法（アレクサンダーからトレガーまで）が登場する以前の歴史的な事件、文化的な潮流、個人的な出来事を記す。その上で、「ソマティック・ムーヴメント・エデュケーション・アンド・セラピー」を定義し、ソマティック実践者ら3世代にわたって成長してきたソマティック・ムーヴメント・プログラムについて説明する。

［本研究で得られた］インタビュー・データから明らかになったのは、第2世代の多くがダンサーであったこと、そしてダンス専門家たちの「ボディマインド思考」が「ダンス・ソマティクス」と同様に、ソマティック・ムーヴメントのトレーニングとソマティック・エデュケーションの発展を形成し続けていることである。

最後に、ダンスとソマティック・ムーヴメントの両方が西洋文化のなかで疎外されているという問題を提起する。そして両者の共通の特徴と推進力を組み合わせることを提言することによって、ダンスとソマティック・ムーヴメントの［学術的な］位置づけを変えることを試みる。本稿のもう一つの所見は、世界的な図式のなかの「ソマティック・ダンス」の勢力と立ち位置を評価したことである。
Una breve historia de las prácticas somáticas y la danza: desarrollo histórico del campo de la educación somática y su relación con la danza1
Authors: Eddy Martha , Barragan Traducción: Rosana
Published: February 2023

Este artículo describe el desarrollo histórico de las prácticas de movimiento somático, especialmente en relación con la danza, los bailarines y las organizaciones que trabajan en el campo de la educación de la danza. El artículo comienza con eventos históricos, tendencias culturales y sucesos individuales que llevaron al surgimiento de los métodos somáticos ‘clásicos’ a principios del siglo XX (desde Alexander hasta Trager). Luego define ‘la educación y la terapia del movimiento somático’ y el crecimiento de tres generaciones de programas de movimiento somático. La información obtenida a través de entrevistas revelan cómo una segunda generación incluyó una gran cantidad de bailarines y menciona cómo la idea ‘cuerpo-mente’ de los profesionales de la danza continúa moldeando la formación y el desarrollo de la educación somática, así como la ‘danza somática’. Finalmente, el artículo plantea preguntas sobre la marginalización de la danza y de la educación somática, y sugiere combinar fuerzas gracias a las características comunes de las dos prácticas para así examinar su lugar en la cultura occidental. Adicionalmente, se ofrece una evaluación de cómo está ubicada la ‘danza somática’ a nivel global.
Cartografía operativa de actividades invisibles. Ciudad Abisal: atlas de iniciativas culturales sumergidas en la ciudad de Valladolid (2017)
Authors: Rodríguez-Andrés Jairo , De los Ojos Jesús , Fernández Catalina Manuel , Muñoz-López Ana
Published: February 2023

El proyecto Ciudad Abisal surgió con el ambicioso objetivo de identificar, visibilizar y valorar de manera amplia los nuevos procesos de cultura de base e independientes de la ciudad de Valladolid, así como con el de localizar estas propuestas, promocionarlas y por tanto conseguir impulsar la acción de sus agentes. El proyecto tuvo que sumergirse en este territorio de la cultura de base alternativa, prácticamente invisible, operando al mismo tiempo con su cercanía, su diversidad y sus controversias. Para ello, con el objetivo de plasmar de la mejor manera posible esta realidad física, social y económica concreta, el estudio pretendía superar el concepto de cartografía y fue concebido como un atlas a modo de herramienta enriquecida. El texto expone el proceso de diseño llevado a cabo en la consecución de los recursos gráficos necesarios para retratar, desde la perspectiva del estudio, estos acontecimientos, la ciudad y la relación entre ambos. Defiende la necesidad de recurrir a técnicas y estrategias evolucionadas, no tradicionales, para describir realidades nuevas difícilmente representables. Igualmente enuncia el conjunto de resultados arrojados por el estudio, en modo de conclusiones y propuestas de acción, fruto de la construcción de un diagnóstico participado por los agentes protagonistas. Apoyándose en las consecuencias que sobre la ciudad construida y sus dotaciones ha tenido el estudio, en forma de reutilización arquitectónica de un espacio abandonado como sala de exposiciones primero y Centro de Iniciativas Creativas después, reafirma el poder transformador que sobre el contexto tienen este tipo de cartografías operativas. Ciudad Abisal consiguió pivotar de lo no visible a lo visible, desbordando el marco teórico y proyectándose en un primer lugar y de manera amplia a la ciudadanía, y en un segundo término, como resultado más visible, alterando de manera física las dotaciones de la ciudad al servicio de la cultura.
A tudástranszfer újszerű lehetőségei a virtuális és kiterjesztett
valóság segítségével
Authors: Petzné Tóth Szilvia , Csiszár Viktória
Published: February 2023

A mai világban az oktatási környezet, oktatási módszerek
napról-napra változnak. Virtuális környezetben képesek vagyunk saját magunk
és környezetünk megjelenítésére is a tevékenységeken keresztül. A diákok
távolabbi helyekről is meg tudják magukat jeleníteni, képesek a többiekkel
együtt interaktívan dolgozni. A hagyományos online környezethez képest
lényegesen bővül az oktatási környezet megjelenítési lehetősége, a valós
térhez hasonló 3D-s térbeli megjelenítés segítségével. A virtuális oktatási
környezetben végbemenő tanítási-tanulási folyamatokat segítő gyakorlatokat,
feladatokat kívánunk bemutatni írásunkban, megadva az oktatási,
visszacsatolási lehetőségeket is.
Empatía, agresividad y perdón en contextos de vulnerabilidad, hostilidad y seguridad en niños y adolescentes
Authors:   Universidad Católica de Colombia, Bogotá, Colombia, Toro Ronald , Barreto-Zambrano María Luisa ,   Universidad Católica de Colombia, Bogotá, Colombia, Garzón-Velandia Diana Camila ,   Universidad Católica de Colombia, Bogotá, Colombia, Sandoval-Escobar Marithza ,   Fundación Universitaria Konrad Lorenz, Bogotá, Colombia, Pineda-Marín Claudia ,   Fundación Universitaria Konrad Lorenz, Bogotá, Colombia, O’Sullivan Cadhla ,   Queen’s University Belfast, Antrim, Northern Ireland, Taylor Laura ,   Queen’s University Belfast, Antrim, Northern Ireland, Kerezsy-Morales Giuliana Katharina ,   Universidad Católica de Colombia, Bogotá, Colombia, Giraldo-Puerto María Angélica ,   Universidad Católica de Colombia, Bogotá, Colombia, Cárdenas-Ruiz Sofía ,   Universidad Católica de Colombia, Bogotá, Colombia, Ramírez-Sierra Yineth Vanessa ,   Universidad Católica de Colombia, Bogotá, Colombia, Alfonso Diego ,   Fundación Universitaria Konrad Lorenz, Bogotá, Colombia, Duarte Valderrama Juliana Valentina ,   Fundación Universitaria Konrad Lorenz, Bogotá, Colombia, Niño Amézquita José Luis ,   Universidad EAN, Bogotá, Colombia
Published: February 2023

Introducción: El objetivo de este artículo fue identificar las variables que mejor predicen las medidas de agresión, empatía y perdón, como también las principales diferencias en contextos vulnerables, hostiles y seguros, en una muestra de niños, niñas y adolescentes pertenecientes a una población vulnerable. Método: se realizó un estudio cuantitativo transversal con una muestra no probabilística incidental de 85 participantes, se emplearon medidas psicométricas para la empatía, agresión y perdón. Los participantes fueron convocados en unafundación de atención a víctimas para realizar una entrevista y aplicar el test. Resultados: Se encontraron efectos estadísticamente significativos entre las variables del modelo verificado, donde la empatía predice la agresión en el contexto hostil, pero no en el vulnerable y seguro. A su vez, la empatía predice el perdón en los contextos vulnerables y seguros, y la agresión predice el perdón en el modelo hostil, pero no es significativo su efecto en el contexto vulnerable y seguro. Además, la empatía tiene un papel clave en la comprensión del perdón, dado que se asocia a conductas agresivas en los contextos de hostilidad, mientras que un modelo de perdón debería ser diferencial en estos contextos. Conclusiones: Los hallazgos de este estudio brindan evidencia empírica que sustenta la importancia de la implementación de estrategias para mejorar las habilidades relacionadas con la empatía en niños y adolescentes, desde la perspectiva de la educación para la paz y el perdón. Además, se demostró que los aspectos como el clima familiar, las vulnerabilidades de los contextos de riesgo y la misma cultura, pueden determinar el desarrollo de habilidades socioemocionales que favorecen el perdón, empatía y otras capacidades interpersonales.
Heterogeniczność macierzyństwa w teorii Simone de Beauvoir
Authors: Elert-Gadacz Kinga
Published: February 2023

Celem artykułu jest analiza koncepcji heterogeniczności w teorii Simone de Beauvoir, której praca przyczyniła się zarówno do rozwoju filozofii i etyki feministycznej jak i badań nad macierzyństwem. Punkt wyjścia stanowi złożona krytyka instytucji patriarchalnego macierzyństwa, przymusowego macierzyństwa, demistyfikacja instynktu macierzyńskiego oraz mitu Matki. Antyesencjalistyczna perspektywa Beauvoir umożliwiła artykulację ucieleśnionego doświadczenia, ambiwalencji oraz alienacji w macierzyństwie. Artykuł stanowi zatem próbę reinterpretacji pism Beauvoir w kontekście etyki niejednoznaczności oraz „antropologicznej rewolucji”, które stały się wyrazem oporu, walki o prawa i sprawiedliwość reprodukcyjną. Autorka podejmuje również kwestie dobrowolnej bezdzietności, wykluczenia matek oraz problem płciowego podziału pracy.
Book review of: Werner, Oliver (2022): Wissenschaft ‚in jedem Gewand‘? Von der „Reichsarbeitsgemeinschaft für Raumforschung“ zur „Akademie für Raumforschung und Landesplanung“ 1935 bis 1955
Authors: Kegler Harald
Published: February 2023

Buchrezension.
Identification of Pathogenic Microflora and Its Sensitivity to Antibiotics in Cases of the Odontogenic Purulent Periostitis and Abscesses in the Oral Cavity
Authors: Mochalov Iurii , Kryvtsova Maryna , Chobey Andrij , Kulynych Mariya
Published: February 2023

Odontogenic infections are the most common infectious and inflammatory diseases of the maxillofacial area and problem of the causative pathogen identification is an actual task, part of a permanent process of updating and modernization of treatment and diagnostic protocols and standards. In presented study a purulent exudate from 13 patients with acute purulent odontogenic intraoral lesions was studied by bacteriological method with detection of sensitivity to antibacterial agents. Bacteriological studies showed that genus Streptococcus predominated in 69.23% cases. Pathogenic microorganisms in clinically significant concentrations (105 per 1 ml and above) (Streptococcus and Staphylococcus) were resistant to Tetracycline and Doxycycline, had moderate sensitivity to macrolides in 22.22% and resistance in 77.78%. Amoxicillin/clavulanate caused effective growth retardation in 22.22% cases and moderate delay – in 77.78% without cases of resistance. Sensitivity to cephalosporins was detected in 50.00% cases, moderate sensitivity – in 38.89%, resistance – in 11.11%. Fluoroquinolones were the most effective – sensitivity in 72.22% cases, moderate sensitivity – in 22.22%, resistance – in 5.56%. The most effective fluoroquinolones were Moxifloxacin and Ciprofloxacin. The highest resistance to antifungal agents was shown by genus Candida, antifungal susceptibility was observed only in 20.00% cases. The microbiota of purulent odontogenic inflammation in the oral cavity was identified in clinically significant concentrations in only 61.54% cases with predominance of Streptococcus. The most effective antibacterial agents for odontogenic purulent process may be considered among cephalosporins and fluoroquinolones. There is a need to repeat similar studies in other regions of Ukraine and at other times of the year.
Evaluation of Turkish oregano (Origanum onites L.) under organic farming system
Authors: Toaima Wael Ismail Mohamed , Hamed Emad Saleh , Abd El-Aleem Wafaa Hamed
Published: February 2023

Spice production is crucial for the world economy. Today, the farming of spices faces significant challenges under climate change, such as heat stress, rising salinity, water stress, low soil nutrients, and increased pests, which lead to reduced yield and quality. The present study was conducted in Egypt on Turkish oregano (Origanum onites L.) plants. The trial was achieved under organic farming conditions. The purpose was to investigate the responses of the plant towards two natural stimulators, chitosan and biofertilizer. The design of the work was a split plot. Main plots were assigned to the foliar spray of chitosan at three concentrations (0, 5, and 10 liters/hectare) and sub-plots to biofertilizer EM (with and without). The collected data comprised plant height, fresh and dry herb weights per plant, fresh and dry herb yields per hectare, essential oil percentage, oil yield per plant and hectare, and GC-MS analysis of oils. The significant maximum growth and yield characteristics were obtained by spraying with chitosan at the highest concentration of 10 liters/hectare combined with soil drenching by biofertilizer EM. The major essential oil component was carvacrol, which is responsible for its pungent flavour. This previous treatment also recorded the maximum carvacrol percent in oil of all cuts. So, this treatment could be used to increase the quantity and quality of the organic product.
Podróż wokół pstrągów: Put na Plitvice Adolfa Vebera Tkalčevicia. Tekstotwórcza rola motywów kulinarnych
Authors: Pieniążek-Marković Krystyna
Published: February 2023

Adolfo Veber Tkalčević (1825–1889) a Croatian philologist, writer, passionate traveler and a Catholic clergyman is the author of the first Croatian account of the travel to the Croatian “Lake District” Put na Plitvice (Road to Plitvice, 1860). As a travel narrative, this book has a “worldbuilding” potential, introducing the Plitvice Lakes to Croatian culture, to the national landscape. In this article,Ifocus on the culinary theme of the trip. One of its side goals was savouring the trouts, but throughout the entire trip the tables of wanderers did not want to fill with them, offering the text-forming abundance instead. The journey “around theempty table” is a kind of self-portrait of “explorers” ready for a “heroic” attitude for the common good. Bearing in mind the specificity of Croatian Romanticism, which this work represents, I read the text in a cultural, anthropological and identity context, referring to the classics of discourse, and devoting less attention to travel studies.
Is Asking Questions Free of Charge? Questioning the Value of Independent Central Banks through the Lens of a European Credit Council
Authors: Thiemann Matthias
Published: February 2023

This discussion of Eric Monnet's idea of a European Credit Council evaluates the likely consequences of such a new institution. Based on a critical examination of the notion of economic expertise, it warns that such a council might legitimate an untenable status quo, while bringing little positive benefits. Such a council could however exercise a subversive role if its counterexpertise were to expose the limits to central bank independence in the context of the climate crisis, thus undermining the current set-up. Yet to play such a role would require a degree of confrontation which is unlikely to emerge from the council's envisioned setup.
An outlier detection method with CNN for BeiDou MEO moderate-energy electron data
Authors: Chao Tian , Ruifei Cui , Riwei Zhang , Peikang Xu , Libo Chen , Jie Shang , Lin Quan , Yujun Wan , Sihui Hu , Fulu Yue , Xing Su
Published: February 2023

BeiDou Medium Earth Orbit moderate-energy electron detection data play an important role in space environment effect analysis including satellite anomaly diagnosis, satellite risk estimation, etc. However, the data contain outliers which cause obstacle for the subsequent usage significantly. To solve this problem, we propose an outlier detection method based on convolutional neural networks (CNNs) which can learn a rule from labeled historical data and detect outliers from the detection data. With this method, we can identify outliers and do some follow-up operations to improve the data quality. In comparison with general methods, this CNN method provides a more reliable and rapid way to build dataset for the follow-up work.
Soy isoflavone reduces LPS-induced acute lung injury via increasing aquaporin 1 and aquaporin 5 in rats
Authors: Wang Xiaobo , Zhang Yili , Zhou Xiuyun , Xia Xiumei , Teng Weijun , Sheng Lin , Ding Jing
Published: February 2023

Acute lung injury (ALI) followed with severe inflammation and oxidative stress. Anti-inflammatory and antioxidant are the properties of aquaporin 1 (AQP1) and aquaporin 5 (AQP5). The goal of this study was to see if soy isoflavone can diminish lipopolysaccharide (LPS)-induced ALI and the underling mechanism. LPS-induced ALI was given to Sprague–Dawley rats 14 days following oophorectomy. One hour before the LPS challenge, estradiol (1 mg/kg) was administered subcutaneously as positive control and soy isoflavone was intragastric administration for 14 days prior to LPS challenge with different doses. Six hours after LPS challenge, the pulmonary edema, pathophysiology, inflammation, and the oxidative stress in lung tissues of rats were discovered. We found that soy isoflavone can reduce pulmonary edema and the lung pathology in a dose-dependent manner. Furthermore, tumor necrosis factor-alpha, interleukin-1β, and interleukin-6 were decreased in rats treated with soy isoflavone. Meanwhile, soy isoflavone reduced pulmonary oxidative stress by decreasing malondialdehyde levels, while increasing superoxide dismutase levels in lung tissues in a dose-dependent manner. Mechanically, we found that the mRNA and protein level of AQP1 and AOP5 were increased in lung tissues of rats treated with soy isoflavone compared the LPS-treated rats. Thus, soy isoflavone alleviates LPS-induced ALI through inducing AQP1 and AQP5.
Interkultur durch Kultur: Das leitfadengestützte Tandem-Projekt
Authors: Han Ding , Triebiger Marleen , Wang Zhenghao
Published: February 2023

Die Autoren gehen davon aus, dass eine Anleitung zum Tandemlernen mit kulturbezogenen Aufgaben, die die Lerner dazu motiviert, im Team jenseits des Klassenzimmers gemeinsam Aufgaben und Projekte zu bewältigen, der Sprachlernsituation im Tandem dienlich ist. Im vorliegenden Beitrag werden die Ergebnisse einer Untersuchung an der University of International Business and Economics in Beijing mit 20 deutschen und 20 chinesischen Teilnehmern dargelegt, die in Beijing mit Hilfe eines Leitfadens im Tandem Deutsch bzw. Chinesisch gelernt haben. Der Leitfaden gibt jeweils in der Muttersprache der Teilnehmenden anleitende Hinweise zur Fremdsprachenvermittlung, zum Fremdsprachenlernen und speziell zum Lernen im Tandem. Der Kern des Leitfadens sind acht Lektionen mit kulturbezogenen Aufgaben, die ausgewogen chinesische wie auch deutsche Themen beinhalten. Die Auswertung der Untersuchung anhand von 26 Umfragen und 14 Interviews mit den Projekt-Teilnehmern zeigt, dass Lernerfahrung in Sprachpartnerschaften durch Anleitungen zum Lernen im Tandem und durch kulturbezogene Aufgaben in deutsch-chinesischen Tandems verbessert werden können. In dem Beitrag werden auch die Unzulänglichkeiten dieser Studie und potentielle Richtungen für die künftige Forschung diskutiert.
Die Pläne der EU-Kommission für einen CO₂-Grenzausgleich
Authors: Söllner Fritz
Published: February 2023

Das CO₂-Grenzausgleichssystem der EU kann die Verlagerung der Produktion beziehungsweise von Emissionen in Drittländer nur zum Teil verhindern. Es wird sehr hohe Kosten verursachen, nicht zu einer kosteneffizienten Emissionsreduktion beitragen und kaum Anreize für Drittländer schaffen, ihre Emissionen zu reduzieren. Das System ist nicht WTO-konform und wird deshalb Anlass zu handelspolitischen Streitigkeiten und Konflikten geben, unter denen vor allem Deutschland mit seinen hohen Exportüberschüssen zu leiden haben wird. Es spricht vieles dafür, das vorgeschlagene System nicht zu realisieren und die Wettbewerbsnachteile europäischer Unternehmen weiter durch die teilweise gratis erfolgende Zuteilung von ETS-Zertifikaten auszugleichen.
“She of Uriah” (Matthew 1,6): An Evocative and Multivalent Genealogical Annotation
Authors: Aernie Jeffrey W.
Published: February 2023

This article examines an aspect of Matthew’s unique reference to Bathsheba that is often neglected in discussions of the women in the genealogy, namely the position of this genealogical annotation within the three-part generational structure of Matthew’s genealogy (Matt 1,17). It will be argued that consideration of the structural position of this annotation points to its intentional multivalence. Matthew refers to Bathsheba as “she of Uriah” to create conceptual and structural connections with multiple components of Jesus’s genealogy. To develop this thesis, the article discusses the integrated narrative function of Matthew’s genealogical annotations, examines the distinct structural position of “she of Uriah” within the genealogy, and demonstrates how its multivalence sharpens contemporary readings of the women in Matthew’s genealogy.
Mit realistischem Blick – Lukanische Perspektiven auf Geld
Authors: Wojtkowiak Heiko
Published: February 2023

The widespread tendency to see money as primarily or even exclusively negative in Luke deserves critical scrutiny. On the contrary, it can be shown that Luke views money with a clear-eyed realism, including a broad acceptance of the role that money plays in everyday human life. On the parabolic level, the importance of money is recognized even beyond its necessity for ensuring immediate survival, and monetary institutions such as earning interest or money changers are used as analogies. Even in texts with critical perspectives on money, no purely negative assessment is given. The significance of Luke’s nuanced perspective on money is shown by the light it sheds on our understanding of the parable of the Dishonest Manager.
τὰ στοιχεῖα τοῦ κόσμου Again: Interpreting Cosmos in Gal 4,3 and 9 as Prepuce (or Foreskin)
Authors: Barrier Jeremy W.
Published: February 2023

The meaning of the phrase τὰ στοιχεῖα τοῦ κόσμου in Gal 4,3 has been debated for nearly two millenia. A new understanding of Paul’s utilization of the term τοῦ κόσμου is considered in this essay. In addition to ὁ κόσμος meaning “the world” in Gal 4,3, an argument can be made that ὁ κόσμος is a reference to the “adornment” of the penis (i. e., the foreskin). The lexicographical evidence supports this reading. In other words, the reference to κόσμος in Gal 4,3 is an additional critique of the Galatians’ decision to circumcise the male members of their communities.
Ein Geist der Besonnenheit? Σωφρονισμός in 2Tim 1,7
Authors: Krauter Stefan
Published: February 2023

Almost all current translations of 2Tim 1:7 understand σωφρονισμός in this verse as a synonym of σωφροσύνη. So do authoritative recent commentaries and dictionaries. This paper demonstrates that word formation makes this unlikely and that σωφρονισμός is never used synonymously with σωφροσύνη in ancient Greek literature. It is shown that the usual meaning of “making someone σώφρων” is possible and appropriate for 2Tim 1:7. A survey of ancient translations and interpretations of the verse by ancient Christian writers shows that most of them also consider this meaning possible and obvious.
Frühaufklärung produktionskritischer Diskontinuitäten
Authors: Dobler Richard , Frech Nicolas , Reinhart Gunther
Published: February 2023

Um Industriebetrieben die Nutzung von Chancen und die Vermeidung von Risiken durch Diskontinuitäten zu ermöglichen, ist ein geeigneter Frühaufklärungsansatz notwendig. Obwohl Frühaufklärungssysteme bereits entwickelt wurden, gilt es weiterhin, eine Methodik zu erforschen, die sich insbesondere mit produktionskritischen Diskontinuitäten beschäftigt. Daher wird im Rahmen dieses Beitrags eine solche Vorgehensweise vorgestellt.
KI-Kanban-Behälter
Authors: Rokoss Alexander , Popkes Lennart , Kramer Kathrin , Green Thorben , Schmidt Matthias
Published: February 2023

Mit dem Kanban-Verfahren gesteuerte Produktionssysteme nutzen heute elektronische Unterstützung zur Verfolgung einzelner Behälter, um datenbasiert Logistikprozesse zu verbessern. Dieser Beitrag stellt eine alternative technische Auslegung vor. Es finden mit Sensoren ausgestattete Behälter Verwendung, welche über einen KI-fähigen Mikrocontroller ihren Standort im Produktionssystem dezentral ermitteln, um ohne feste Erfassungspunkte eine permanente Nachverfolgbarkeit der Behälter zu gewährleisten.
Soziotechnische Gestaltung einer intelligenten Personaleinsatzplanung
Authors: Gabriel Stefan , Bentler Dominik , Bansmann Michael , Andrew Latos Benedikt , Kühn Arno , Dumitrescu Roman
Published: February 2023

In diesem Beitrag wird die soziotechnische Gestaltung einer Intelligenten Personaleinsatzplanung beim Unternehmen Miele & Cie. KG im Rahmen des Leuchtturmprojekts „InTime“ im Kompetenzzentrum Arbeitswelt.Plus beschrieben. Hierzu werden die Durchführung und Auswertung einer Interviewreihe sowie das daraus erarbeitete Soll-Konzept vorgestellt.
Systems & Life Cycle Engineering für Strategische Souveränität
Authors: Michels Nico , Bitzer Michael
Published: February 2023

Die Betrachtung von Produkt-Systemen über alle Phasen des Lebenszyklus gewinnt durch aktuelle Trends und deren Änderungsfrequenz zunehmend an strategischer Bedeutung für die Produktentwicklung. Der Ansatz des Systems & Life Cycle Engineerings kann hier genutzt werden, um die Innovation von Produkten zu unterstützen, um die Strategische Souveränität zu befähigen.
Klimamanagement zur Verbesserung der CO2-Bilanz in der Produktion
Authors: Budde Felix , Gellert Benjamin , Orth Ronald , Kohl Holger
Published: February 2023

Einzelne Klimaschutzmaßnahmen werden bereits von vielen Unternehmen erfolgreich umgesetzt. Doch oftmals fehlen ein systematischer Ansatz sowie die finanziellen Ressourcen zur Umsetzung eines konsequenten Klimaschutzes unter Beibehaltung des wirtschaftlichen Erfolgs. In diesem Beitrag wird ein Vorgehensmodell zur zielgerichteten und potenzialorientierten Ableitung und Umsetzung von Klimaschutzmaßnahmen im Rahmen eines betrieblichen Klimamanagements vorgestellt. Der Fokus liegt dabei auf kleinen und mittleren Unternehmen des produzierenden Gewerbes.
Effiziente Stagnationswasser-Entfernung in trinkwassertechnischen Anlagen
Authors: Gallin Paul , Rudolph Mathias , Brandt Ulf , Scheiba Stefan
Published: February 2023

Verweilzeiten zwischen werkseitiger Montage und Gebäudeinstallation führen bei trinkwassertechnischen Kompaktanlagen zur Stagnationswasser-Kontamination. Um die daraus resultierende Kontamination des Trinkwassernetzes bei einer Gebäudeinstallation zu vermeiden, sollte Restwasser bereits werksseitig entfernen werden. Im selben Prozessschritt können Anlagen desinfiziert oder sterilisiert werden. Im Rahmen eines Kooperationsprojektes wurde ein entsprechendes System entwickelt.
Denmark’s referendum on cancellation of the defense opt-out
Authors:   Institute of Europe of the Russian Academy of Sciences, Babynina Liudmila
Published: February 2023

On June 1, 2022, a referendum was held in Denmark, according to which the country canceled its existing exceptions within the framework of the EU defense policy. Denmark will now be able to take part in all activities of the CSDP, including the projects of permanent structured cooperation (PESCO). The referendum results were affected by external factors, mainly the events in Ukraine. The author assesses the referendum results and consequences of abolition of exceptions in the field of defense for Denmark, the EU in general and the CSDP in particular.
Saarland – Donbass: the policies of economic reintegration after the self-determination referendum
Authors:   Institute of Europe, Russian Academy of Sciences, Kotov Alexander
Published: February 2023

We examine the parallels between the self-determination referendum in the predominantly German-speaking region of Saar in 1955 and Donbass upholding of the right to determine its own political and economic path after the military conflict in 2014-2021. In this regard, we develop a description of the experience of economic reunification of the Saarland with compatriots in the rest of Germany in the areas of maintaining and developing a system of social benefits, intensifying trade, stabilizing regional markets, strengthening the regional economic structure, etc. The unique experience of Saarland integration can play an important role in the development and adaptation of measures of economic and regional policy that are similar in meaning if the population of the people's republics of Donbass approves further integration into the constitutional and economic space of Russia.
Connected Biology
Authors: Ellis Rebecca , Mead Louise , Reichsman Frieda , McElroy-Brown Kiley , Smith James , White Peter
Published: February 2023

Evolution is often challenging for high school students to understand because it encompasses an array of interlinked processes that occur across a broad swath of biological scales. To help address this, we have developed a set of freely accessible, online, and interactive lessons that focus on the evolution of sweet garden peas from their starchy tasting ancestors. Gregor Mendel first explored the genetics of garden peas in the mid-1800s; our materials help students explore the basis of the R and r alleles from genetic, protein, cell function, artificial selection, and population genetics perspectives. These Next Generation Science Standards (NGSS)–linked lessons integrate concepts across scales and are designed to be used in a flexible order, with support provided to teachers on how to choose a sequence that meets their students’ needs. Throughout, students act as scientists as they uncover how multiple processes at disparate scales all worked together in the evolution of sweet and wrinkled peas from ancestors that were starchy and round.
Simple preparation of a sunshine -like bismuth oxyiodide nanosheets for photocatalytic degradation of organic pollutant under sunlight
Authors:   Imam Mohammad Ibn Saud Islamic University (IMSIU), College of Science,  Chemistry Department, Riyadh, KSA, Algethami F. K. , Elamin M. R. ,   Industrial research and consultancy center (IRCC), Khartoum-North, Sudan, Abdulkhair B. Y. ,   Sudan University of Science and Technology (SUST), College of Science,  Chemistry Department, Khartoum, Sudan
Published: February 2023

The spread of organic pollutants in water is encountering colossal problems worldwide, and it gets worst as the industry progresses. Among the suggested solutions, heterogenous photocatalysis was progressively applied to degrade organic pollutants. Herein, a simple ethylene glycol refluxing (EGR) method was optimized to fabricate bismuth oxyiodide (BiOI) nanoparticles with a percentage yield of 94.2%. The EGR method's success in preparing BiOI nanomaterial was confirmed by the results of X-ray diffraction, energy dispersive spectroscopy, and Fourier-transform-infrared spectroscopy. The scanning-electron-microscopy and the transmission electron microscopy analysis revealed that the sunshine-like nanosheets are composed of tiny nanoparticles. The BiOI was employed for photocatalytic degradation of organic pollutants under visible light. The adsorption capability of BiOI was investigated prior to its photocatalytic activity, and both investigations showed appealing results. The outcomes of this study nominated both the EGR method for fast preparation of a nanoscale BiOI and the applicability of BiOI as a photocatalyst to swap the organic pollutants from contaminated water using the free-inexhaustible sunlight.
Synthesis and characterization of Bi2O3 NPS and photocatalytic application with methylene blue
Authors:   Department of Chemistry, Khadir Mohideen College, Adirampattinam.  614701(Affiliated to Bharathidasan University, Tiruchirappalli) India, Ali F. S. , Ragamathunnisa M. ,   Department of Physics, Government Arts College for Women (Auto),  Pudukkottai, 622001, India, Al Marzouqi F. ,   Department of Chemistry, College of Science, Sultan Qaboos University, Muscat,  Oman, Jahangir A. R. M. ,   Biyaq Oilfield Services LLC Post Box: 795, Mina Al Fahal PC, 116, Muscat,  Sultanate of Oman, Ayeshamariam A. ,   Department of Physics, Khadir Mohideen College, Adirampattinam.  614701(Affiliated to Bharathidasan University, Tiruchirappalli) India, Kaviyarasu K. ,   Kasinathan Kaviyarasu, UNESCO-UNISA Africa Chair in  Nanosciences/Nanotechnology Laboratories, College of Graduate Studies,  University of South Africa (UNISA), Muckleneuk Ridge, P O Box 392, Pretoria,  South Africa,   Nanosciences African network (NANOAFNET), Materials Research Group  (MRG), iThemba LABS-National Research Foundation (NRF), 1 Old Faure Road,  7129, P O Box 722, Somerset West, Western Cape Province, South Africa
Published: February 2023

Bismuth oxide nanoparticle was synthesized by Hydrothermal method, with two different molar ratio of precipitating agent of NaOH which decided the variations of two samples (1:5) and (1:6) was added to observe its effect on structural, optical and photocatalytic behaviour. So the prepared bismuth oxide nano particle was characterized by X-ray Diffractometer to study about its crystalline properties. The crystal size was observed as 30.7 and 42.84 nm, The optical properties were characterized by using UV-Vis spectrometer and its band gap value was calculated as 2.74 eV and 2.42 eV respectively. Morphological studies were obtained by using scanning electron microscopy and the elemental X-ray analysis confirmed the proportions of Bi2O3 nanoparticles of two samples (1:5) and (1:6). FTIR Spectrometer studies explained the condensation of OH group accompanied by the formation of Bi2O3 which is strongly dependent on the pH of reaction. A lattice change was observed, symmetric and asymmetric bonds were analysed by using FTIR spectrometer. The binding energy and its energy level were analysed by using X-ray Photo electron Spectroscopy and its value was 292 and 534 eV, and also the hydrothermal synthesised Bi2O3 NPs was used to analysed the photocatalytic degradation of Methylene blue under the irradiation of LED white light.