bluuebunny/crossref_metadata_2025 huggingface dataset:
Ayurvedic management of Dadru (dermatophytosis)
Authors: Sahoo Smrutimayee , Yadav Pramod , Prajapati Pradeep Kumar
Published: June 2022

Diagnosis and management of skin diseases are a challenge for practitioners. Dadru is a common clinical condition, which is considered under the broad heading of Kustha (~skin disorders). Dadru is a Pitta-Kapha Dosha predominant disease which is characterized by Raga (~reddish discoloration), Pidaka (~eruptions), Kandu (~itching at the site of the lesion), and Mandala (~elevated circular patches). On the basis of clinical features, it has the closest resemblance with dermatophytosis which is a superficial infection caused by a group of fungi. It is a major health problem having faster spreading in nature. We present here a case of 24-year-old male having lesions on the medial side of the lower left leg and left knee, thus diagnosed with Dadru with chronicity of four years. He was treated with the internal administration of Siddharthaka yoga kwatha and external application of Siddharthaka yoga ointment. The total treatment duration was 28 days. Significant remission in clinical features of Kandu, Raga, Pidika, and Mandala was observed within 28 days of treatment without any complication, which becomes an evidence and base for further research works with a larger sample size.
Heavy metal contamination in water sources of Thaliparamba municipality, Kerala, India
Authors: Nafeesa Baby T. P. , Vineethkumar V. , Shimod K. P. , Vishnu C. V. , Jayadevan Sarayu
Published: June 2022

The present study is an attempt to assess the heavy metal contamination in the water sources of Thaliparamaba Municipality, Kannur district, Kerala. The concentration of heavy metals, namely As, Cr, Fe, Mn, Cu, Zn, Ni, Cd, Hg, and Pb in water samples was measured using X-ray fluorescence spectroscopy. The physicochemical parameters, namely pH, electrical conductivity, and salinity of the water samples were also measured. The results indicate that the concentration of most of the heavy metals in water samples collected from the study area is much higher than the permissible limits. The anthropogenic activities may influence the enhanced level of heavy metal concentration in the study area. The results of these systematic investigations are presented and discussed in detail in the manuscript.
A study on the optimization of processing parameters of boron-doped CR-39 solid-state nuclear track detectors for response to thermal neutrons
Authors: Sathian Deepa , Pal Rupali , Bakshi A. K. , Sapra B. K.
Published: June 2022

The methodology for personnel monitoring of neutrons in the intermediate and fast energy range using CR-39 solid-state nuclear track detectors (SSNTDs) is well established. This study presents the dosimetric response of boron-doped (carborane) CR-39 detector for the measurement of thermal neutrons. It includes optimization of etching process, minimum detection limit (MDL), and thermal neutron sensitivity. Duration of low frequency (100 Hz) and high frequency (3.5 kHz) for elevated temperature electrochemical etching was optimized as 4 h and 50 minutes respectively, and used for the response characteristic study. The measured thermal neutron sensitivity and MDL were 743 ± 13 tracks cm−2 mSv−1 and 0.02 mSv, respectively. This study is useful for thermal neutron monitoring in reactor, accelerator, and all other nuclear facility environment.
Radiological assessment of petroleum products in Aniocha South Local Government Area of Delta State, South-South Nigeria
Authors: Ijabor Blessing Okeoghene , Omojola Akintayo Daniel , Omojola Funmilayo Ruth , Chukwueke Favour Chinyere , Azuka Praise Kidochukwu , Agama Prudent , Okafor Francisca Mmesoma
Published: June 2022

Monitoring the background levels from petroleum products is essential because of the everyday use and the increasing number of fuel, diesel, kerosene, and gas stations in Delta State, Nigeria. The study aims to determine the background ionizing radiation (BIR) in milli-Roentgen per hour (mR/h), absorbed dose rate (ADR) (nGy/h), and annual effective dose rate (AED) (mSv/year) in selected fuel, diesel, kerosene, and cooking gas-dispensing stations in Aniocha South Local Government Area of Delta State. The study was carried out using a calibrated Geiger Muller detector (Radiation Alert Inspector) in count per minute mode for point measurements and a geographical positioning system for determining the longitude and latitude of each point where measurements were taken from. The mean outdoor BIR, ADR, and AED were 0.011 ± 0.002 mR/h, 91.6 ± 19.5 nGy/h, and 0.11 ± 0.02 mSv/year, respectively, with 84% of the BIR below the world average. The mean BIR was below the world average while the ADR and AED were above it. Kerosene stations had the highest BIR. The outdoor measurements from this study were comparable to similar articles with slight variation. The study shows that the attendant and customers were safe in the areas where this study was conducted.
Translating Texts: An Introductory Coursebook on Translation and Text Formation
Authors: Pahor Tadej , Pisanski Peterlin Agnes
Published: June 2022

Translating Texts: An Introductory Coursebook on Translation and Text Formation, a textbook intended for trainee translators in both language-specific and language-neutral translation courses, as well as for language students, provides authentic materials designed to promote text awareness. It offers students an opportunity to gain insight into a text-centered approach to translation, fostering systematic reflection on macro and- micro-textual features of selected genres.
Changes in mental and sexual health among MSM using HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: longitudinal analysis of the SwissPrEPared cohort study
Authors: Winter Babette L. , Hovaguimian Frédérique , Kouyos Roger D. , Schmidt Axel Jeremias , Bernasconi Enos , Braun Dominique L. , Calmy Alexandra , Notter Julia , Stoeckle Marcel , Surial Bernard , Christinet Vanessa , Cavassini Matthias , Depmeier Carsten , Läuchli Severin , Boffi El Amari Emmanuelle , Reinacher Matthias , Rasi Manuela , Bruggmann Philip , Haerry David , Bize Raphaël , Low Nicola , Lehner Andreas , Quednow Boris B. , Fehr Jan S. , Hampel Benjamin
Published: June 2022

BACKGROUND: Changes in mental and sexual health among men having sex with men (MSM) due to the SARS-CoV-2 pandemic remain unclear.
METHODS: Design: Longitudinal analysis of an ongoing, multicentre, pre-exposure prophylaxis (PrEP) cohort (NCT03893188) in Switzerland. Participants: HIV-negative MSM aged ≥18 who completed at least one questionnaire before and one after the start of the SARS-CoV-2 pandemic. Outcomes: Primary: mental health, defined as anxiety and depression scores assessed by the Patient Health Questionnaire-4. Secondary: sexual behaviour, well-being, PrEP use and disruption of care. Outcomes were assessed over seven periods corresponding to different SARS-CoV-2 prevention measures in Switzerland. We performed pairwise comparisons between periods (Wilcoxon signed rank test).
RESULTS: Data from 1,043 participants were included. Whilst anxiety scores remained stable over time, depression scores worsened in the second wave and the second lockdown period compared to pre-pandemic scores. This was confirmed by pairwise comparisons (pre-SARS-CoV-2/second wave and pre-SARS-CoV-2/second lockdown: p <0.001). Downward trends in sexual activity,sexualized substance use, and a switch from daily to "event-driven" PrEP were found. Disruption of care affected 42.6% (790/1856) of daily PrEP users’ follow-up visits.
CONCLUSION: In this longitudinal analysis of a PrEP cohort enrolling MSM, depression scores worsened in the second wave and the second lockdown compared to the pre-pandemic period.
Private Military and Security Companies (PMSCs) in the Modern International Processes
Authors: Nebolsina M. A.
Published: June 2022

The period of rapid growth and development of the phenomenon, that is presently characterized as private military and security companies (PMSCs), coincided with the two processes of modern history of international relations: the end of the Cold War and the beginning of the U.S. Global War on Terror (GWOT) in Afghanistan. At the same time state attitude towards violence and transformation of warfare has been changing as well. Two diff erent approaches to the history of the private security market’ rise unveil the fact, that, in one way or another, the originators of the private security services were associated with the defense industry and armed forces. Non-state security actors look back on a history, that stretches to the middle and the second half of the 20th century – the period of national liberation movements across the world. Meanwhile, the 90-s of the 20th century marked the fast growth in the number of PMSCs and in the development and enlargement of the private security services’ market. Its growth is ongoing to date with gaining more new states that are interested in utilizing its capacity as an instrument of politics. Against the backdrop of the world political processes the private security market experienced technological growth and enhancement. Together with that, both the normative regulation and the approaches of the international community to the phenomenon of private military and security companies have been evolving and changing. Despite its functionality, fl exibility and technological advantages, the market of private security can challenge human rights as well as bare responsibility for the facts of corruption and improper fulfi llment of contractual obligations. Still the episodes of revealed grieve violations rarely reach courts, with infrequent cases of sentencing the perpetrators to punishment. These and other problems occurring in the private security industry require close attention by the states and international community, which has been making eff orts for elaboration of the applicable normative mechanisms to regulate private military and security activity for more than fi fteen years.
From “Countering” To “Constructing” Russian Threats in Mikheil Saakashvili’s Georgia
Authors: Sikharulidze A. T.
Published: June 2022

This paper looks at the securitization process that took place during M. Saakashvili’s time as President of Georgia. It argues that, in order to overshadow political misdeeds and non-democratic state-policy as a whole, M. Saakashvili and his political allies used “constructed” Russian threats to discredit and marginalize opponents. Furthermore, M Saakashvili’s regime tended to restrict freedom of speech, civil liberties and other democratic rights by referring to non-existent constructed threats from the Moscow. Through security dimension, Russia poses a menace to Georgia’s territorial integrity, sovereignty and Western aspirations. But at the time of M. Saakashvili’s presidency it has been turned into a political tool to be used against opponents. This paper off ers a scholarly debate on the issue. Finally, it gives a case-by-case analysis of the most crucial happenings that explain “how” and “why” Russia has been securitized.
Space as a Competition Domain: Threats and Opportunities
Authors: Stefanovich D. V. , Porras D.
Published: June 2022

The article deals with the unfolding race for military, technological, and political infl uence in space. Great powers have competed in space since the dawn of the Space Age. Today we are once again faced with the possibility of space warfi ghting, but there are more than two players in the game now and civil infrastructure depends on space more than ever before. Theoretical space war threats are often analysed through an assessment of possible targets. And there are real-life challenges and threats here, including but not limited to rendezvous and proximity operations (RPO), existing destructive anti-satellite (ASAT) capabilities, non-destructive electronic warfare, and cyber and jamming capabilities. The greatest threat, though, comes from simple misperceptions of actions in space by diff erent actors. Space cannot be separated from dynamics on Earth, but there might be some room for space-specifi c confi dence-building, risk reduction and even arms control measures.
Identification of Parallel-Cascade Wiener System using Tensor Decomposition of an associated Volterra kernel
Authors: Ben Ahmed Zouhour , Derbel Nabil
Published: June 2022

In this paper, we propose tensorbased methods for identifying nonlinear Parallel- Cascade Wiener (PCW) systems. Parameters of linear subsystems are first estimated using an approach based on the PARAFAC decomposition of the associated pth-order Volterra kernel. This approach consists in applying the Alternating Least Squares (ALS) algorithm. Then the coefficients of nonlinear subsystems approximated as polynomials are estimated by mean the least square sense from the reconstructed output of the linear subsystems. The proposed parameter estimation method and its performance are illustrated by means of simulation results.
Implementation of Self-education Principles as a Background of Quality Professional Education
Authors: Shutov D. , Anosova A. , Krychkivska O. , Vorona A. , Solodka L.
Published: June 2022

Education is an important component of the life of every society member. Studying in educational institutions alone is not, however, enough in order to be successful. This is the reason why self-education has become widespread. The aim of this work was to study the implementation of the self-education principles in specialized education, focusing on the principles of regularity, consistency, the relationship between selfeducation with education and self-education with professional activities. This aim was achieved through a pedagogical experiment conducted in general secondary and higher educational institutions, as well as through surveys of pupils, students, nursery school teachers, school teachers and lecturers/professors. Statistical data on the dynamics of the teaching staff of educational institutions were analysed through mathematical methods. The experiment found that the introduction of methods that contribute to the development of self-educational competence, self-control and self-organization in educational institutions also has a positive effect on the academic performance of pupils and students. These methods improve cognitive activity and increase motivation of educational activities, social interaction and purposefulness, point out gaps in acquired knowledge and help to implement a differential approach. The study demonstrated that self-education should be consistent and regular, starting with general secondary education and accompanying specialists throughout their professional carriers. finding effective teaching methods that can be used in educational institutions at different levels and that contribute to the development of skills and abilities to independently improve acquired knowledge may be the subject of further research.
An Evaluation of Myths and the Social Magic of Symbols as Communicative Archetypes of Culture
Authors: GÖÇER Ferhat
Published: June 2022

ABSTRACT

In this study, an evaluation is made on the importance of myths and symbols which emerged as the most important haunt in the struggle for existence starting with the falling of man into a cultural playground, in terms of social communication. Culture creates a new reality ring for human beings apart from natural and physical reality. The communication of this reality takes place through myths and symbols in ancient times. Myths and symbols have existed as important archetypes in the ancient history of man. Humankind has tried to understand and explain the phenomena of the world he lives in through myths and symbols. Myths and symbols are effective in human life; At the same time, they are a binding force in the survival of social life. In the formation of a collective magic, they are interwined archetypes that have an important place in the past, present and future of man. First of all, these archetypes have fulfilled an important function regarding the social communication in terms of overcoming the uncertainties of the objects, processes and developments of the human and society. This operation; continues to exist in today's societies, albeit indirectly.
The Impact of European Union Tourism Policies on Turkish Tourism in The Context of Envıronment and Sustainabilıty: The Mucilage Problem of the Marmara Sea
Authors: GARİPAĞAOĞLU UĞUR Nihan , İSTANBULLU DİNÇER Fatma Füsun
Published: June 2022

Denizlerin kirlenmesinin hem ekonomik hem de sosyal etkileri bulunur. Avrupa Birliği’nin (AB) çevre politikaları kirliliği azaltılmasını amaçlarken, doğal kaynakları dengeli şekilde kullanmayı ve sürdürülebilir kalkınmayı da içerir. Çalışmanın amacı Marmara Denizinde yaşanan kirliliğin, Avrupa Birliği turizm politikaları ve AB müktesebatı içinde yer alan “tüketicinin ve tüketici sağlığının korunması” ile “çevre” maddeleri çerçevesinde değerlendirilmesidir. Çalışma betimsel olup ikincil verilere dayandırmıştır. Yaşanan çevre sorununun AB politikaları ve Türk turizmi üzerindeki etkilerinin analiz edilmesi yönüyle literatüre katkı sağlaması beklenmektedir. Türkiye turizm stratejisi 2023 ile uluslararası markalaşarak, istihdamı arttırmayı ve sürdürülebilir bir gelişimi hedeflemiştir. AB turizm politikaları ile Türkiye turizm stratejileri 2023’ün genel olarak uyumlu olduğu görülmektedir. Bununla birlikte tüketicinin korunması ile ilgili kurallara nispeten daha az yer verilmiştir. Çevresel etkilerin en aza indirgenmesi ve Marmara Denizi’nin kirlenmesinin önlenebilmesi için, yetkililerin kirliliği kaynağında tespit ederek gerekli önlemleri alması, geri dönüşüm yapılarak, atık suların arıtılması ve sulama işlemlerinde kullanılması gerektiği sonucuna ulaşılmıştır.
Widespread Virtual Life with Blockchain, Deepfake, Avatar, Cryptocurrency, NFT and Metaverse
Authors: KAHRAMAN Mehmet Emin
Published: June 2022

The idea of living in different worlds, starting with cinema, can be seen as the beginning of the virtual world. Because, although limited for a certain period of time, cinema and television, which disconnected the audience from the real world, allowed them to get away from real life and imagine different lives. Later, with the invention of the internet, the power of the computer increased and virtual life continued to be offered to users through websites and games. With the nickname feature, users are able to take their place in the v,rtual world with different identities other than their own has also started. This understanding formed the basis of the understanding of avatars. Especially with computer games, the use of avatars has increased as each user starts to create their own avatar in the virtual world. Big data was created by archiving personal data with social media, and cryptocurrencies and deepfake applications developed by making virtual life more professional with virtual reality/augmented reality were offered to users. In the research, the development of this whole process and the positive and negative effects of Metaverse, which companies such as Facebook, Microsoft, Epic, Roblox, Nvidia, Unity Software, continue to design rapidly, on people and real life are emphasized.
METAVERSE İŞLETMELERİ SANAL TAKIMLARA SÜRÜKLER Mİ?
Authors: KILIÇ ÖZKAYNAR Gülnaz
Published: June 2022

Değişimin çok hızlı olduğu bu çağda, işletmelerin yapılanmalarında değişikliklerin olması kaçınılmaz bir durumdur. Teknolojik gelişmelere bağlı olarak ortaya çıkan sanal takımlar, işletmeler için bir alternatif olmaya başlamıştır. Özellikle son yıllarda yaşanan pandemi sebebiyle bazı sektörlerde sanal takım oluşumlarının arttığı görülmektedir. Her koşulda müşterinin taleplerine cevap vermek için çabalayan işletme sahipleri, sanal takım yapılanmaları ile pazarda varlığını sürdürmeye devam etmek istemektedir. Diğer taraftan günümüzün dikkat çekici konularından biri olan metaverse ise gerçek dünya ile sanal dünyanın birleşmesi sonucu ortaya çıkan yeni bir evren yapılanmasıdır. Geleceğini şimdiden şekillendirmek isteyen işletmeler, metaverse hakkında araştırmalara başlamış hatta yatırımlarını dahi bu alana yönlendirmeye çalışmaktadır. Metaverse ve sanal takımların en önemli kesişme noktaları ise her ikisinin de internet tabanlı faaliyet göstermeleridir. Metaversede yer almaya başlayan işletmeler sanal takım oluşturma gayretleri de hızlanacaktır. Bu çalışmanın amacı sanal takım yapılanmasını ele alarak metaversenin bu oluşuma etkisini teorik olarak incelemektir. Diğer taraftan bu durumun işletmelerde ortaya çıkarabilecek yansımaları da tartışılmaktadır.
Intentional binding as an implicit measure of the sense of agency
Authors:   NRC «Kurchatov Institute», Yashin Artyom S. ,   Lomonosov Moscow State University, Dubynin Ignat A. ,   Center for Neurocognitive Research MSUPE
Published: June 2022

Intentional binding (IB) is the effect of the subjective temporal attraction of an action and its result. This effect is often viewed as an implicit measure of the sense of agency — a person's awareness of his or her own actions. In our review, we conduct an analysis of various studies reporting the correlation between IB and the sense of agency. We take into account a number of relevant differences between experimental methods, e.g., various techniques for measuring IB. Our review also considers the emergence of IB in the performance of joint actions, as well as the influence of factors such as the delay between the action and the signal, the modality of the signal, the valence of the result of the action, and so on. We conclude that IB manifests itself differently depending on the way it is measured, i.e. the uniform nature of the effect is dubious. IB is influenced by both low-level and high-level processes, which interact with each other and modulate the strength of the effect to varying degrees. As a result, the effect reflects not only the presence of the sense of agency but also the predictability of events in the experiment, as well as the presence of a representation of an action. At the same time, one of the sources of ambiguity in the existing studies is the use of different concepts of the sense of agency by different authors, which is reflected in the interpretations of the results. At the end of the review, we formulate recommendations for future experiments which are meant to take into account the methodological shortcomings of the existing studies. We also point out the most promising directions in the research of IB and present some conceptual difficulties in interpreting the experimental results.
IMPACT OF CORONAVIRUS (COVID-19) ON THE GLOBAL ECONOMY
Authors: Kudriavtseva Alena S. , Arkadeva Olga G.
Published: June 2022

The COVID-19 pandemic and associated lockdowns have hit the global economy and affected the basis of the socio-economic and business models, which have already undergone some complex changes. Industrialized countries are witnessing a steady decline in interest rates and GDP growth rates, possibly due to medium-term demographic and technological changes, a growing demand for savings assets, and increasing divergences between individuals, firms, and regions. In conditions of the demographic transition, pension provision and health care are placing an additional burden on the state budget. These trends are increasingly restricting monetary and fiscal policy to stabilize the economy in the event of adverse shocks. On the technological side, the digitalization of consumption and production requires structural adjustments in various areas in order to remain competitive and create new opportunities for displaced jobs. For a number of years, globalization has been facing serious obstacles associated with growing protectionism and skepticism about the universal benefits due to ever-increasing international trade and financial integration. The article focuses on the interaction of these trends and the shock caused by COVID-19. International economics and economic policy deal mainly with macroeconomic, trade and technological aspects. The article concluded that measures to restore the economy should be comprehensive, not limited to individual areas.
Surveys of Stroke Patients and Their Next of Kin on Their Opinions towards Decision-Making and Consent for Stroke Thrombolysis
Authors: Angamuthu Nithia , Queck Kian Kheng , Menon Sumytra , Ho Shu Swen , Ang Elaine , De Silva Deidre Anne
Published: June 2022

Introduction: Early initiation of stroke thrombolysis is associated with improved outcomes. Procurement of consent is a key factor in prolonging the door-to-needle duration. This study aimed to determine the attitudes and preferences of stroke patients and their next of kin (NOK) towards decision-making for stroke thrombolysis in Singapore. Materials and Methods: We surveyed acute ischaemic stroke patients (n = 171) who presented beyond the 4.5-hour therapeutic window and their NOK (n = 140) using a questionnaire with scenarios on obtaining consent for intravenous thrombolysis. Results: In the patient survey, 83% were agreeable for their NOK to decide on their behalf if mentally incapacitated and 74% were agreeable for the doctor to decide if the NOK was absent. In the NOK survey, the majority (81%) wanted to be consulted before mentally capacitated patients made their decision; 72% and 74%, meanwhile, were willing to decide on behalf of a mentally capacitated and mentally incapacitated patient, respectively. In the scenario where a doctor recommended a mentally incapacitated stroke patient to undergo thrombolysis but the family declined, there was a near equal split in preference to follow the family’s or doctor’s decision in both the patient and NOK surveys. Conclusion: The survey found that in the decision-making process for stroke thrombolysis, there was no clear consensus on the preference for the decision maker of the mentally incapacitated patient. In Singapore, there is a strong influence of the NOK in decision-making for thrombolysis. Key words: Door-to-needle time, Reperfusion, Therapeutic window
Prospecção de compostos derivados do ácido cinâmico com potencial antimelanoma
Authors:   , Vale Juliana Alves do
Published: June 2022

Melanoma é um tipo de câncer altamente agressivo e letal. As altas taxas de mortalidade estão atreladas à sua capacidade de gerar metástases. Uma vez que os tratamentos atuais apresentam resultados insatisfatórios e o melanoma tem se mostrado resistente a muitos deles, faz-se necessária a prospecção de novos compostos com potencial antimelanoma. Nesse contexto, compostos sintéticos têm sido produzidos com o intuito de melhorar outros que servem como scaffold para a síntese de novas moléculas, como derivados do ácido cinâmico. O ácido cinâmico é um ácido graxo de ocorrência natural muito utilizado na criação de novos compostos. Derivados do ácido cinâmico já apresentaram diversas atividades biológicas, inclusive antitumoral. Desse modo, o objetivo geral desse estudo foi avaliar o potencial antimelanoma de derivados do ácido cinâmico em modelo experimental in vitro de melanoma murino B16-F10. No primeiro capítulo foi feita uma introdução geral do assunto, com uma justificativa do trabalho. No segundo capítulo foi realizada uma extensa revisão do uso de células de melanoma como modelo para o screening de drogas. Já os capítulos três e quatro são artigos de pesquisa com derivados do ácido cinâmico. Em ambos os artigos foram feitos a síntese dos compostos e ensaios biológicos de citotoxicidade, proliferação e metástase para avaliação da atividade antimelanoma dos compostos. No capítulo três o composto 6b ((((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(1H-1,2,3-triazole-1,4- diyl))bis(methylene) (2E,2'E)-bis(3-phenylacrylate) foi selecionado por apresentar melhor Índice de citotoxicidade (IC 50 ), sendo esse de 57.66 µM. Além disso, em concentrações abaixo do IC 50 , o composto interferiu no ciclo celular e no comportamento metastático de células B16-F10, diminuindo migração, invasão celular e a formação de colônias. Já o capítulo quatro, o composto 3q (phenyl 2,3-dibromo-3-phenylpropanoate) foi selecionado, apresentando IC 50 de 60.28 µM. Esse composto não interferiu na viabilidade de células não- tumorais. Além disso, em concentração acima do IC 50 provocou apoptose nas células de melanoma, enquanto em baixas concentrações impactou o ciclo celular e a proliferação, além de reduzir o comportamente metastático das células, como pode ser visto nos ensaios de migração, invasão, adesão, colonização celular e polimerização da actina. Enquanto o composto 3q é um éster de ácido cinâmico, um cinamato com átomos de bromo em suacomposição, o composto 6b é um bis cinamato contendo porções 1,2,3-triazólicas. Mesmo com características diferentes, os compostos apresentaram significativa atividade biológica em células de melanoma B16-F10. Portanto, os derivados do ácido cinâmico são compostos promissores para o tratamento do melanoma. Palavras-chave: Ácido cinâmico. Atividade antitumoral. Melanoma.
Educação Fiscal: Mensuração do Nível de Conhecimento e Influência dos Fatores Socioeconômicos
Authors: Da Costa Júnior Agenário Luiz , Saporito Antonio , Henrique Marcelo Rabelo , Silva Sandro Braz
Published: June 2022

A educação fiscal da população é essencial para qualquer sociedade. O objetivo deste estudo foi demonstrar a importância da educação fiscal para a população em geral e simultaneamente avaliar o nível de conhecimento acerca desse assunto dos discentes matriculados na UNIFESP, do campus Osasco no ano de 2018, verificando se fatores socioeconômicos são relevantes como variáveis explicativas de conhecimento entre os vários estratos sociais. Em termos metodológicos, utilizou-se de abordagem quantitativa e a tipologia se deu por meio das pesquisas bibliográfica e exploratória. Recorreu-se também à análise descritiva e à regressão múltipla para tratar os dados referentes a um questionário aplicado a 233 discentes do campus Osasco, satisfazendo o requisito de estarem matriculados no ano de 2018 em ao menos um dos cinco cursos ofertados. Composto por duas partes, o questionário permitiu na primeira, traçar um perfil socioeconômico dos estudantes do Campus, com a segunda se incumbindo da avaliação de conhecimentos relacionados à educação fiscal. Foi possível concluir que o conhecimento específico dos estudantes na área de educação fiscal é insatisfatório, que o conteúdo relacionado a princípios tributários é aquele de menor domínio e que os fatores socioeconômicos não são significativos para distinguir o nível de conhecimento fiscal dos discentes do campus Osasco, ou seja, não foram observadas diferenças significativas de conhecimento entre estudantes pertencentes aos diversos estratos sociais. Políticas públicas efetivas para disseminar a educação fiscal em todos os níveis educacionais, portanto, são imprescindíveis e há poucos estudos com a natureza empregada neste artigo.
Dental manifestations of a paediatric patient with Goldenhar syndrome: a case report
Authors: Al Ghamdi Sara Ayid
Published: June 2022

Goldenhar syndrome (GS) is a rare congenital disorder. It arises from the first pharyngeal pouch, first branchial cleft, first and second branchial arches, and primordia of the temporal bone. It mainly involves abnormalities in the ear, mandibular, and maxillary arches, and is associated with variable clinical features such as skeletal, cardiac, and renal systems. The presence of extra teeth in the dental arch is called supernumerary teeth, and hypodontia refers to congenitally missing teeth. The occurrence of both these anomalies in the same patient is called concomitant hypohyperdontia. However, the GS itself is not very rare, though the presence of concomitant hypohyperdontia has not been reported. The purpose of the present case report is to describe the first case from Saudi Arabia with a characteristic combination of rare findings in a seven-year-old child with comprehensive oral rehabilitation.
Keywords: Goldenhar syndrome, anomalies, dental treatment.
Thyroid gland neoplasms; histopathological pitfalls as a consequence of FNAC: a tertiary care hospital experience
Authors: Pyarali Maheen , Uneeb Saher , Adeel Maira , Aqil Shakil , Zahid Yousra
Published: June 2022

Fine-needle aspiration cytology (FNAC) is one of the useful procedures for the investigation of thyroid swellings. FNAC is a minimally invasive procedure, is cost effective, and a gold standard for diagnosing thyroid lesions. Haemorrhage, thrombosis, and infarction are known common complications of FNAC. Post FNAC infarction in thyroid gland has been known as a rare phenomenon. Here, we report the case of a young female who underwent FNAC that showed Hurthle cell neoplasm (Bethesda 3). Four weeks later, she underwent right thyroid lobectomy and the final histology showed extensive necrosis and haemorrhage which is a diagnostic dilemma and hampered our diagnosis.
Keywords: Hurthle cell neoplasm, FNAC, Thyroidectomy, Thyroid neoplasm.
Radiobasilic transposition arteriovenous fistula (RBTAVF): an effective but less frequently used haemodialysis vascular access- A Case Report
Authors: Riaz Tahira , Zia Ur Rehman  , Saood Ahmed Riaz
Published: June 2022

Radiobasilic transposition arteriovenous fistula (RBTAVF) is often ignored as an option for haemodialysis access. We present the case of a 57-year-old male patient who presented at the AKUH vascular clinic, Karachi, for the creation of long-term haemodialysis vascular access. He had small-sized forearm cephalic vein (1.5 mm), but reasonable sized basilic vein. He underwent successful RBTAVF. Most of the guidelines recommend brachiocephalic fistula (BCF) as the second choice following radiocephalic AVF. This case recommends the inclusion of RBAVF as the second choice for vascular access in international guidelines, in addition to BCF and BBF.
Keywords: Chronic kidney disease, Fistula, Haemodialysis access.
International and national perspective of disability and policy disconnect in Pakistan: a narrative review
Authors: Mumtaz Nazia , Saqulain Ghulam
Published: June 2022

In the developed societies, supportive environmental, physical and social conditions enable participation of persons with disabilities in the mainstream through actions, like provision of ramps and reserved parking. In contrast, in the developing countries like Pakistan, with focus on visual disability, years lost to disabilities compromise and restrict the productive life span of the disabled. The current narrative review was planned to highlight the perspective of disability in the context of Pakistan to bring to limelight the issues requiring immediate focus of the health authorities and the government through a holistic and sustainable approach. Of the 177 publications found on literature search, 33(%) English-language, full-text studies were reviewed. To address disability issues, long-term sustainable actions, like health reforms, including ensuring availability of rehabilitation professionals in hospitals, legislative reforms to initiate relevant legislations, capacity-building of persons with disabilities, including their mainstreaming, are deemed essential.
Association of social & psychological aspects of quality of life and educational level of patients with different orofacial cleft
Authors: Ahmed Mahnoor Mansoor , Shahid Nameeka , Mumtaz Nazia , Ghulam Saqulain
Published: June 2022

Objective: To determine the social and psychological domains of quality of life of children with orofacial clefts in the context of different types of clefts and educational levels.
Method: The cross-sectional study was conducted at Clapp Hospital and Mayo Hospital, Lahore, Pakistan from September 1, 2020, to January 3, 2021, and comprised subjects of either gender aged 6-18 years having orofacial clefts. Data was collected using the CLEFT-Questionnaire along with a basic demographic sheet. Data was analysed using SPSS 23.
Results: Of the 80 subjects, 40(50%) each were males and females. The overall mean age was 12.41±3.39 years. A significant association of types of orofacial clefts with social function (p<0.05) and psychological function (p<0.05) was observed. The highest mean score of 27.89±3.41 and 26.11±1.76 was noted for unilateral left side cleft lip, and primary palate, respectively. No significant association of level of education with social function (p>0.05) and psychological function (p>0.05) was noted.
Conclusion: Different types of orofacial clefts affected the psychological and social aspects of quality of life of patients differently, but the difference was not significantly correlated with the education level.
Key Words: Cleft lip, Cleft palate, Cleft lip palate, Quality of life, Psychological, Social, Educational level.
Pregnancy outcomes with confirmed SARS-CoV-2 infection during first wave: a review
Authors: Naz Memon Farah , Naz Saima , Tayyaba Rahat
Published: June 2022

Maternal and foetal care has become an important concern in the wake of enormous global spread of coronavirus disease-2019 (COVID-19), but there is scarcity of information about maternal and perinatal outcomes. The current review was conducted from March to July 2020. Appropriate and related databases were searched electronically by using terms, like “COVID-19 and pregnancy”, “pregnancy outcomes of COVID-19”. Pooled analysis of the reviewed studies showed that of the 164 newborns, vertical transmission was noted in 7(2.95%). The most common element 140(84.98%) was caesarean section deliveries. COVID-19 pneumonia developed in almost 54(30.90%) of 175 women. The most common symptom of COVID-19 among women was fever 88(50.77%). Adverse maternal and foetal outcomes were found to be associated with COVID-19 in the form of severe illness, increased rates of caesarean section deliveries and worse birth outcomes. Yet, vertical transmission of COVID-19 infection remains debatable.
Key Words: COVID-19, Maternal outcomes, Perinatal outcomes.
Diálogos entre as artes, a educação e a história
Authors: Costa Thays Alves , Ribeiro Diego
Published: June 2022

O objetivo deste artigo consiste em desenvolver um diálogo entre as artes, a educação e a história, contemplando as dimensões histórica e crítica das produções de Rosana Paulino e de Luís Gama. A primeira, artista contemporânea, apresenta em suas obras referências diretas à história do Brasil, como uma espécie de denúncia e de reparação do nosso passado tão violento e lastimável no contexto da escravidão. Já o advogado e poeta Luís Gama foi um dos personagens importantes do movimento abolicionista brasileiro, sendo um dos responsáveis por estabelecer estratégias jurídicas para a libertação dos escravizados, além de desenvolver uma rica obra literária, como o livro de poemas As Primeiras Trovas Burlescas de Getulino, de 1859. Desse modo, este artigo vai apresentar o ato de resistência por meio da poesia de Luís Gama e do desejo de reparação na arte de Rosana Paulino, que demonstram a importância do estudo desses personagens na educação básica.
História da origem dos cestos Kaingang
Authors: Pantu João Natalino , Santos Tadeu dos , Souza Sheilla Patrícia Dias de
Published: June 2022

Este artigo apresenta  estudos sobre a cestaria e pinturas em cestos Kaingang por duplas de professores Kaingang junto a artistas, professores e estudantes do curso de Artes Visuais da UEM. Foram utilizados referenciais metodológicos interdisciplinares associando pesquisa em poéticas visuais, autoetnografia e etnohistória. Os resultados desdobram-se na produção de artigos, feitos também pelas demais duplas de participantes do projeto, que contribuem para a divulgação sobre aspectos da arte indígena, subsidiando a prática dos professores de Artes.
Konumsallık, Mülakatlar ve Göç Çalışmalarında Araştırmacı Olmak
Authors: Irgil Ezgi
Published: June 2022

Bu makale, araştırmacı olarak içinde bulunulan, özellikle göç çalışmalarındaki, konumsallık tartışmalarına katkıda bulunmayı hedeflemektedir. Göç alanındaki mevcut akademik çalışmalar, araştırmacının konumsallığını göçmen topluluğun içinden olan içerideki araştırmacı ve kendi kimliğinin dışında bir kimliğe sahip göçmen topluluk ile etkileşimde olan dışarıdaki araştırmacı diye ele alır. Bu makale, araştırmacının ev sahibi topluluğun içinden kabul edildiği ve mülakat sorularının göçmen bir gruba dair olduğu bir konum olan atfedilen içerideki kategorisini ortaya koymaktadır. Bu kategori ile aynı menşee sahip olmanın etnik kimliğin ötesine geçen bir özellik olarak ortaya çıktığını ve görüşmecilerin ev sahibi topluluğa mensup olmasının, göçmen topluluğa mensup olmasından farklı etik boyutlar içermesinden dolayı ayrı bir kategori olarak ele alınması gerektiğini savunmaktadır.
BRANDING DESA SEMPADIAN SEBAGAI PENGHASIL KOPI UNTUK MENDUKUNG DIVERSIFIKASI PRODUK UNGGULAN DESA
Authors: Lang Jagat Lang Jagat
Published: June 2022

Kopi merupakan komoditas ekspor penting bagi Indonesia yang mampu menyumbang devisayang cukup besar. Dari beberapa daerah penghasil kopi di Kalimantan Barat, KabupatenSambas merupakan salah satu Kabupaten di Provinsi Kalimantan Barat yang memiliki areaperkebunan kopi terluas ke-2 dengan jenis Kopi liberika (coffea liberica). Saat ini kopiliberika Sambas belum terkenal seperti beberapa penghasil kopi yang saat ini beredar dipasaran, sehingga perlu dirumuskan beberapa strategi upaya pengenalan desa (villagebranding) dengan mengangkat berbagai keunggulan desa yang memiliki areal dan tanamankopi, sehingga desa berusaha untuk membangun “branding” desa sebagai adopsi dari modelcity branding, atau country branding. Dengan adanya village branding membuat suatu desamenjadi lebih memiliki keunggulan yang berbeda, memiliki kekhasan dan keunikan denganidentitas yang kuat. Desa yang menjadi target kegiatan pengabdian untuk branding sebagaipenghasil kopi adalah Desa Sempadian, karena beberapa petani yang telah mengelola kebunkopi dengan baik, dan telah membentuk kelompok tani kopi liberika serta memiliki kelompokmasyarakat/UKM yang mengolah kopi. Tahun 2019 kopi sempadian ikut berpartisipasi dalamkegiatan festival kopi Nusantara yang dilakukan oleh Kementrian Desa di Kepulauan NiasSumatera. Metode kegiatan dalam kegiatan ini adalah penentuan model branding, pemilihanchannel branding berupa sosial media, youtube dan media massa, serta pembuatan kaosbranding kopi Sambas. Selain itu untuk mendukung program juga dilakukan pelatihan danpembinaan petani dan pemberian bibit kopi liberika kepada masyarakat yang belummenanam. Kegiatan pengabdian ini dapat membantu branding kopi lokal Sambas sehinggakopi liberika Sambas bisa dikenal, meningkatkan harga dan permintaan pasar yang besarsehingga kopi liberika Sambas bisa menjadi salah satu produk unggulan kopi Nasional.
ALTERNATIF PENGEMBANGAN USAHA BADAN USAHA MILIK DESA (BUMDes) BINJAI ABADI DESA JIRAK KECAMATAN SAJAD
Authors: Sunardi Sunardi
Published: June 2022

BUMDes Binjai Abadi berada di Desa Jirak Kecamatan Sajad. Keberadaan BUMDes BinjaiAbadi ini merupakan upaya untuk mendukung munculnya kembali demokrasi sosial di DesaJirak. Melalui peningkatan kapasitas masyarakat desa tentang pengelolaan BUMDes secaraberkelanjutan dan pemerintah desa yang berpola kreatif dan inovatif dalam mendominasikegiatan ekonomi desa. BUMDes diharapkan dapat membangun perekonomian daerah yangdibutuhkan untuk menciptakan lapangan pekerjaan baru, menghasilkan barang dan jasasubstitusi daerah, meningkatkan perdagangan antar pemerintah daerah dan memberikanlayanan yang optimal bagi konsumen. Namun realitas di lapangan menunjukkan bahwaBUMDes Binjai Abadi masih menghadapi kendala. Kendala yang dihadapi adalah BUMDesBinjai Abadi hanya memiliki satu unit usaha yaitu usaha penggilingan padi dengan produkutama yang dihasilkan adalah beras dan dedak (bahan pakan ternak). Hal ini mengakibatkansumber pemasukan dana pada BUMDes Binjai Abadi menjadi sangat minim. Melihat kondisiini, maka penting untuk dilakukan perencanaan pengembangan unit usaha alternatif untukmerealisasikan produk-produk rencana desa sekaligus meningkatkan optimisme masyarakatterhadap BUMDes Binjai Abadi. Kegiatan yang dilakukan adalah identifikasi faktor internaldan eksternal yang disusun dalam matrik SWOT. Selain itu disusun formulasi rencanapengembangan unit usaha BUMDes Binjai Abadi dengan memaksimalkan kekuatan yangdimiliki BUMDes Binjai Abadi terutama akses modal yang kuat untuk meraih peluangpengembangan unit usaha. Banyaknya limbah sekam padi dan sampah rumah tangga yangdapat dikelola menjadi pupuk organik menjadi potensi kuat yang mendukung rencanapengembangan unit usaha. Selanjutnya dikembangkan pertanian organik yang memberikanpeluang usaha baru.
PEMBUATAN LABEL KEMASAN UNTUK MENINGKATKAN NILAI JUAL PRODUK MAKANAN UMKM DI DESA DALAM KAUM
Authors: Salahuddin
Published: June 2022

Perkembangan kehidupan dan zaman memberikan dampak perubahan pada olahan pangan dan kemasannya. Pada zaman awal , fungsi pokok kemasan  makanan yang awalnya hanya bertujuan untuk melindungi dan menjaga kebersihan, saat ini sudah beralih ke fungsi turunan lainnya seperti estetika , iklan, branding produk.

Tujuan dan target yang ingin dicapai dalam PKM ini adalah melakukan  pendampingan perbaikan kemasan yang menarik pada industri rumah tangga Produk Makanan olahan.

Desain kemasan adalah visual perwajahan, bentuk, bahan, dan pencitraan yang ingin ditampilkan pada sebuah kemasan untuk meningkatkan performa produk. Bagi produk, kemasan bukan sekedar sebagai pembungkus semata, tetapi berperan juga sebagai alat bantu pemasaran, pencitraan produk, menampilkan identitas, legalitas, dan sebagai sumber informasi produk kepada konsumen.

Pengabdian ini dilakukan selama 8 bulan di Desa Dalam Kaum Kecamatan Sambas. Program ini menghasilkan produk olahan Makanan dengan kemasan dan label yang memiliki nilai ekonomis
Cultivation of Sight-reading Ability in Piano Education in Colleges and Universities
Authors: Lai Yuanhua
Published: June 2022

In the specific piano education in colleges and universities, the sight-reading ability can be said to directly determine the piano playing skills and abilities of college students, and it also highlights the piano education received by students and the actual teaching effect of teachers. According to the important position of piano education in higher education at present, cultivating college students' sight-reading ability in specific teaching has become the main focus of teaching in the current educational field and college teaching system. However, according to the analysis of the actual teaching situation, we know that there are various problems and deficiencies in cultivating students' sight-reading ability in piano teaching in colleges and universities, and at the same time, they are affected by various unfavorable factors, so that students' ability has not been significantly improved after receiving specific education. In this regard, this paper mainly analyzes and studies the cultivation of sight-reading ability in piano education in colleges and universities, and puts forward specific teaching measures.
Research on the Development of Talent Training Mode in Undergraduate Colleges under the Integration of Industry and Education
Authors: Li Wenwu , Li Juan , Li Qin
Published: June 2022

In order to promote the organic integration of social industry and education, colleges and universities must reform the existing education mode. The talent training mode of integration of industry and education is the development trend of undergraduate education in China, and it is also the new normal of college education reform in China. It puts forward new requirements for the improvement of undergraduate education and training mode. How to cultivate high-quality applied talents for the country with higher quality mode will be a new issue that colleges and universities are facing in the new era. This paper focuses on the talent training mode of undergraduate colleges under the integration of industry and education, deeply explores the shortcomings of the current talent training mode in undergraduate colleges, and puts forward innovations and suggestions on the talent training mode under the integration of industry and education in combination with the current market and social requirements, with a view to providing relevant ways and means for the reference reform of the talent training mode of undergraduate colleges.