bluuebunny/crossref_metadata_2025 huggingface dataset:
Women Micromanagement in Private Higher Education UK: A Critical Review
Authors: Tariq Muhammad , Sidhu Ria
Published: March 2024

The primary purpose of women's micromanagement in private higher education institutions in the UK is to attempt to define micromanagement, examining the underlying factors, characteristics and outcomes of such micromanagement practices. This topic is essential for understanding the dynamics within private higher educational institutions and how gender-based management behaviours may influence various aspects of private higher education. A Systematic Literature Review (SLR) is a rigorous research methodology used to gather, analyse, and synthesise existing academic literature onWomen Micromanagement in Private Higher Education UK. We used a systematic and structured approach to identifying, selecting, and evaluating relevant studies on Women Micromanagement in Private Higher Education in the UK from various sources such as Google Scholar, ERIC, JSTOR, and Science Direct, including websites such as Higher Education Statistic Agency (HESA.) The findings of a systematic review of "Women Micromanagement in Private Higher Education in the UK” revealed several significant insights and patterns in the existing literature. The review uncovered a gender disparity in leadership roles generally and within private higher education institutions in the UK, particularly with women often occupying middle management positions while being underrepresented in top leadership roles. Literature also revealed that micromanagement could be good or bad; the negative side is that it drains productivity, inflicts fear, and includes excessive control, which is seen as demotivating. Micromanagement can be advantageous in certain short-term situations. It is not right to label women as micromanagers, and males could also be micromanagers. However, not all studies support the idea that women are more likely to micromanage. Keywords: Women (Gender), Leadership, Private Higher Education
Diety Nike-Victoria of the late Antique period on the territory of Georgia
Authors: Mshvildadze Marika
Published: March 2024

The states on the territory of Georgia were part of the Classical antiquity ecumene. Accordingly, both Iberia and Colchis had close trade-economic and cultural relations with the Roman Empire, from where the deities popular in the empire spread to the territory of Georgia. Among them, a special place is occupied by the ancient god of victory, Nike (Ancient Greek: Νίκη). The name Nike is believed to date back to the pre- Greek period. In Greek mythology, Nike appears as a companion of Zeus and Athena. In Greek art, the deity is mainly depicted with symbols of victory – wings, a crown and a palm branch, but we also find a wingless Nike. In Roman reality, the Victoria (Latin: Victoria) corresponded to Nike. Research has shown that the deity Nike (Victoria) was one of the most widespread cults in late ancient Iberia, which is the result of political and cultural relations with the Greco-Roman world. In late antiquity, the cult of Nike (Victoria) was recorded on the territory of Georgia in the Kingdom of Kartli (Iberia) – on the territory of Greater Mtskheta, Urbnisi, Zhinvali... Since the Hellenistic period, religious syncretism was also reflected on the engraved gems found on the territory of Kartli. Athena-Tikhe-Fortuna- Demeter-Nike depicted in an oval-shaped cornelian intaglio in a fragment of an iron ring. Tomb №27 of Karniskhevi, 2nd-3rd centuries. Nike-Fortuna-Athena is depicted in an oval-shaped white, transparent glass intaglio in an iron seal. Urbnisi necropolis. Tomb №205. 1st-early 2nd century AD. Seals with the image of the deity Nike (Victoria) found in the territory of Georgia belonged to all layers of society. Gemas can be found both individually and in gold, silver and bronze rings. Intaglios with the image of the deity are made of: carnelian, glas, almadine, which are inserted into iron, bronze, silver and gold rings. It is noteworthy that the cult of Nike (Victoria) is mainly prevalent in urban centers. From the above, we can conclude that Nike (Victoria) was popular and in our opinion, mainly among the Romanized population.
The Russian invasion of Ukraine 2022: Discussions and Perceptions inside Academia
Authors: Brusylovska Olga
Published: March 2024

Four issues are most actively discussed in Western literature: the aims of Russian foreign politics (occupy all of Ukraine); the legal basis for supporting Ukraine (what the West could do for Ukraine without worsening relations with Russia); the instruments for supporting Ukraine (sanctions are a key policy tool); and the scenarios for the future. The scenario for Russia means that Russia has become a global business pariah. The scenario for Ukraine is connected not only with the convincing response of the Ukrainian army to the Russian invasion, but also with changes in terms of language, national symbols, patriotic rhetoric, and self-esteem. The scenario for the USA and NATO includes revising and widening their military spending. The scenario for the EU means the emergence of a new concept of the EU’s foreign politics and transition from ‘strategic partnership’ to ‘strategic confrontation’ with Russia.
SAÚDE E CIÊNCIA
Authors: FERREIRA KETHLYN DE OLINDA , NOLASCO LORECI GOTTSCHALK , SUNAKOZAWA LUCIO FLAVIO JOICHI
Published: March 2024

Através do método bibliográfico, o artigo busca compreender o papel do Estado na abordagem da política pública de saúde, mormente em tempos de pandemia sanitária provocada pela doença contagiante entre humanos denominada COVID-19. Cabe ao Estado com o auxílio da sociedade, atender os ditames constitucionais na efetivação do direito fundamental à saúde pública, consequência do fortalecimento do Sistema Único de Saúde, da ciência, bem como do direito à informação adequadas, em tempos de crise sanitária.
LEI DE DROGAS
Authors: LIMA MALUF GLÓRIA MARIA , TURELLA ROGÉRIO
Published: March 2024

O presente artigo busca analisar as prisões ocasionadas pelo crime de tráfico de drogas, que acabam por interferir na atual conjuntura das penitenciárias brasileiras, resultando na superlotação, a fim de compreender a seletividade penal e os princípios infringidos por ela, na medida em que é possível perceber um padrão de raça e classe social entre os encarcerados, segundo as pesquisas que aqui serão expostas. Enquanto isso, objetiva ainda analisar os dados mencionados, os julgados e buscar compreender, sob a luz da Lei 11.343/03 e da Constituição Federal Brasileira de 1988, quais as consequências desse encarceramento em massa. Pretende-se também esclarecer se, na prática, o princípio da presunção da inocência é uma garantia que vem sendo aplicada a todos os cidadãos, sem distinção, e quais fatores influenciam no fato do sistema carcerário possuir, em sua maioria, sua população negra e pertencentes à classe baixa. Tudo isso, a partir do marco teórico da seletividade penal, mediante pesquisa bibliográfica sobre direito penal e o funcionamento do sistema penal moderno, que demonstra que tal seleção existe, tratando de forma discriminatória os que pertencem as classes sociais mais baixas, tema especificamente abordado nesse artigo, e se beneficiam da sua cor da pele ou de sua condição social.

Palavras-chave: encarceramento; padronização; presunção da inocência; tráfico de drogas
O CRIME DE ESTUPRO DE VULNERÁVEL NO DIREITO PENAL BRASILEIRO
Authors: ANTUNES ROMERO BIANCA BEATRIZ , RIBAS BORGES GUSTAVO LENNON
Published: March 2024

No decorrer do presente artigo serão apresentadas as mudanças na legislação penal referente ao crime de estupro de vulnerável e a relevancia da palavra da vítima no momento da investigação. Debateremos acerca das sequelas oriundas dessa prática criminosa, discutiremos os impactos sociais do delito, por meio de análise da legislação vigente, mediante comparativo com a legislação obsoleta. Tem como objetivo discorrer sobre o tema de (estupro de vulnerável) a palavra da vítima e os perigos da condenação, apresentando exemplos de caso e jurisprudências sobre a temática, com um olhar crítico visando melhor entendimento do assunto.
“Hygiene, Agriculture, and Men”: Rural Health in 1930s and 40s Colombia
Authors: Jalil Hanni
Published: March 2024

In 1934, Alfonso López Pumarejo, the recently elected president of Colombia, announced that expanding government programs in public health and education would be a priority for his administration. This article analyzes this period’s cultural transformation programs, examining the establishment and operation of sanitary units, mixed healthcare centers, and itinerant rural health commissions in the 1930s and the 1940s. It proposes a two-part argument. First, it demonstrates how reformers, intellectuals, and doctors associated with Latin America’s first wave of social medicine transformed existing institutional spaces to serve the aims of the government’s new public health model, designing and implementing programs to extend healthcare into the countryside. They proposed shifting from campaigns focused on eradicating a single disease to campaigns that tackled multiple diseases and also advocated for an increase in national, departmental, and municipal fiscal contributions to public health programs. Second, it touches upon the fiscal and resource-related challenges that limited these programs’ reach. These challenges illustrate the fractured and fragmented nature of the Colombian state and its lack of capacity to effectively integrate the countryside by reaching often neglected remote rural areas.
La Última Copa: Alcoholics Anonymous as Behavioral Health Care in Puerto Rico’s Oso Blanco, 1950s-1960s
Authors: Ortiz Díaz Alberto
Published: March 2024

Drawing from a prisoner-produced publication titled Realidad (Reality) as well as other sources, this article explores the history of Alcoholics Anonymous in Puerto Rico’s premier carceral institution in the mid-twentieth century, the Insular/State Penitentiary at Río Piedras. An analysis of the AA penitentiary group La Última Copa (The Last Drink) under colonial populism—an era in which Puerto Rican carceral care revolved around rehabilitation—shows that incarcerated people deemed the group’s activities and their magazine as viable, efficacious behavioral health care options. Socio-humanistic therapeutics like group therapy and testimonial writing were of particular consequence for inmates, who in turn produced multiscalar knowledge about alcoholism and served as frontline practitioners.
On Basic Problems of Energy Law Science: Some Reflections
Authors: Kleandrov Mikhail I.
Published: March 2024

This article discusses issues of the fundamentals of the energy law science, noting their insufficiency in this sphere and the resulting ineffectiveness of both exploratory and applied research. As a result, laws and regulations in the energy sector, which is the basis of the national economy, is also inadequate. The author concludes that while scientific and technological progress in the energy sector is advancing rapidly, its legal regulation is lagging behind. There is a lack of coordination among leading scientific and legal researchers of existing institutions in energy law. The author suggests drastically expanding the scope of comprehensive training for higher scientific qualification personnel majoring in energy law, which would require specialized thesis boards.

In the future, as the mankind masters inexhaustible and voluminous types of energy, such as lightning energy, time energy, and energy formed by the annihilation of matter and antimatter, etc., appropriate laws and regulations will be necessary (it is a must) preceded by scientific and legal study of the issue.
A Study on Work-Related Factors and Safety Concerns Among Indian Migrant Workers in Islamic Gulf Countries
Authors: Mohammed Rafiuddin , Kosalram Kalpana
Published: March 2024

This current study aims to identify the work-related factors that impact both their work and health outcomes. The cross-sectional study conducted from June to October 2023 in Warangal, Telangana, focused on Indian male migrants, especially those working in Saudi Arabia and the UAE. The survey included 350 male migrant workers aged 20 and above, excluding females due to industry-specific regulations. The carefully crafted questionnaire covered physical strain, workplace factors, and safety. Data analysis, conducted in MS Excel, employed statistical measures and tests such as the Chi-square test and Fischer's exact test. In this study, a survey encompassed 350 male migrant workers (204 from Saudi Arabia, 146 from the UAE). Notably, 36.37% were above 41 years old, 50.86% were married, and nearly half had a secondary education, with the UAE showing the highest percentage (69.86%). A significant majority had over 6 years of experience, and a predominant portion worked in construction (35.71%), industry (22.57%), and cleaning (14.29%). Physical strain elements were prevalent, with 63.43% experiencing prolonged sitting and 82.57% facing lengthy standing. Workplace factors included exposure to noise (85.72%), varying temperature conditions, and encounters with dust, smoke, and gas. Concerns were raised about safety at the workplace, with almost 28.57% lacking appropriate personal protective equipment, and 29.14% reporting a lack of emergency response planning. Despite these issues, 72% adhered to safe practices, while 38.86% reported insufficient training. The study underscores the multifaceted challenges faced by migrant workers, necessitating targeted interventions to enhance their working conditions and safety.
MANAGEMENT OF HELLP SYNDROME BEFORE DELIVERY: A COMPREHENSIVE SYSTEMATIC REVIEW
Authors: Christian Roy , Pieter Hetharia Frenki , Bangkit Sumardi Franky , Dwi Rahayu Inggit
Published: March 2024

Background: HELLP syndrome, a rare and serious complication during pregnancy, poses significant risks to both mother and fetus. Early management of HELLP syndrome before delivery may improve the outcomes for patients. This study aims to systematically review literatures on HELLP syndrome management before delivery in the last 10 years.
Methods: This systematic review complied with the PRISMA 2020 standards and focused on full-text English literature published between 2014 and 2024. Articles such as editorials and review papers from the same journal, as well as submissions lacking a DOI, were excluded from consideration. Literature was sourced from online platforms like PubMed and SagePub.
Result: We found 1629 articles on PubMed and 560 articles on SagePub. Restricting our search to the past decade (2014-2024), PubMed presented 507 articles, whereas SagePub presented 288 articles. From these, we selected 5 papers meeting our criteria, with 3 from PubMed and 2 from SagePub.
Conclusion: The main treatment approach for HELLP syndrome involves stabilizing the mother and ensuring timely delivery. Various strategies, including the use of corticosteroids and glucocorticoids, have been explored to reduce the associated morbidity and mortality.
ELECTRIC VEHICLE APPLICATION BASED FUZZY WITH VECTOR CONTROL CONTROLLED HIGH SPEED SRM
Authors: Subbamma Dr. Manne Rama , Jabeer M Mahammed , Sujindrakumar Kopparapu , Mubarak Sthubaigarishaik
Published: March 2024

When used to an electric vehicle (EV), a high-speed motor is a practical means of achieving motor reduction. Since the rotor construction of a switched reluctance motor (SRM) is both simple and sturdy, this kind of motor may be used for highvelocity drives. The driving concept is effective, although it causes significant vibration and noise. Torque controllers are notoriously difficult to build because of the complexity introduced by traditional methods of current excitation. It has been suggested that SRM drive may benefit from the fuzzy with vector control in order to get over these issues. In the high-speed drive, vector control has not yet been implemented on the SRM. In this article, fuzzy control is used to clarify the optimal drive conditions—including switching frequency and bus voltage—for operating the SRM in the high-speed range. Fuzzy with vector control is proven to be able to drive the proposed SRM in the high speed area, allowing for minimum vibration to be achieved.
Effects of Home-Based Pulmonary Training Program on Functional Exercise Capacity and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
Authors: Haider Sumbal , Ain Qurat Ul , Amjad Maha , Sajjad Yasha , Javed Zainab , Kausar Fareeha
Published: March 2024

Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms and airflow limitation. Despite the availability of various treatments, there is a growing interest in exploring more effective strategies to manage symptoms, enhance exercise capacity, and improve the quality of life for COPD patients. Pulmonary rehabilitation, including both supervised and home-based exercises, has emerged as a promising approach.
Objective: The aim of this study was to evaluate the effectiveness of a combined approach of Active Cycle of Breathing Technique (ACBT) with a home-based exercise regimen in improving functional exercise capacity and quality of life in patients with COPD, compared to ACBT alone.
Methods: This was a randomized controlled trial involving 44 COPD patients, divided into two groups: Group A received ACBT alone, while Group B participated in ACBT plus a home-based exercise program. The intervention lasted for four weeks. Outcome measures included the St. George’s Respiratory Questionnaire (SGRQ) for quality of life, the 30-second arm curl test for upper extremity function, and the 6-minute walk test (6MWT) for lower extremity function. Data were analyzed using SPSS version 25, with the Mann-Whitney and Wilcoxon tests for between-group and pre-post intervention comparisons, respectively.
Results: Group B showed more significant improvements in exercise capacity and respiratory symptoms compared to Group A. Specifically, the 6MWT distances increased from an average of 365.60±57.81 meters to 370.40±54.29 meters in Group B, indicating enhanced lower extremity function. Similarly, the SGRQ scores, reflecting quality of life, demonstrated more substantial improvement in Group B, though specific numerical results for this and the 30-second arm curl test were not significantly different between groups.
Conclusion: The study concludes that combining ACBT with a home-based exercise regimen significantly benefits COPD patients by improving functional exercise capacity and potentially enhancing the quality of life. This combined approach could serve as a viable addition to the COPD management strategy, emphasizing the importance of comprehensive, patient-centered care.
The impact of Big Data Predictive Analytics on the performance of Asian firms: Does the supply chain effectiveness matter?
Authors: Soniya Munir
Published: March 2024

The purpose of this research is to evaluate the influence that big data predictive analytics have on the performance of Asian companies and to determine whether or not the efficiency of the supply chain has any bearing on this relationship. The use of a quantitative research design allowed for the collection of data from a representative cross-section of Asian businesses. The findings suggest that big data predictive analytics have a beneficial impact on company performance, and the findings also suggest that the relationship between these two factors is increased by the efficiency of the supply chain. According to the findings, businesses in this region may be able to improve their performance by utilizing big data predictive analytics, particularly when combined with efficient supply chain management. In addition to this, the study sheds light on the significance of effective supply chain management in maximizing the beneficial effects of big data analytics on business performance. This study makes a contribution to our understanding of how the effectiveness of supply chain management and big data predictive analytics play a role in boosting the performance of Asian companies. The findings have repercussions for managers and policymakers in the region, and they underline the necessity to prioritize investments in big data predictive analytics and supply chain management in order to improve business performance.
Examining the mediating role of market performance in the relationship between the big data analytical capability and firm performance
Authors: Naveed Jan
Published: March 2024

The purpose of this study is to investigate how a company's success is related to its capacity to analyze large amounts of data. A quantitative research strategy was used to collect information from 250 companies across several different industries. Partial least squares and structural equation modeling (SEM) were used to analyze the data for this investigation (PLS). The study's findings suggest that companies benefit from being able to analyze large amounts of data since it improves their standing in the market. The study's results also supported the idea of market success acting as a moderator between big data analytic abilities and corporate success. The results show that businesses that are prepared to examine big data have a greater chance of success in the long run. The ramifications of these findings for businesses who want to maximize their big data capabilities and market performance to improve corporate performance are substantial.
Examining The Role of Big Data Analytics and Data Availability on Sustainable Competitive Advantage and Business Performance: Mediating Role of Innovative Capabilities
Authors: Sabir Saeed Ahmad , Sohail Aamir , Sair Shrafat Ali
Published: March 2024

The purpose of this investigation is to examine the role of big data analytics and data availability on sustainable competitive advantage and business performance. Furthermore, the researchers also investigate the mediating role of innovative capabilities between observed variables. The current research used quantitative research design and positivism philosophy to conduct this research. The population of the study, comprised of managers working in different manufacturing companies in Pakistan, the researchers used an adopted questioner to collect data from respondents. Furthermore, a structural equational model was used to test the hypothesis of the study. The research findings indicate that there is a significant mediating influence of innovative capabilities (IC) in the relationship between big data analytics (BDA) and data availability. This mediating effect has a favourable impact on both sustainable competitive advantage (SCA) and firm performance. This highlights the crucial significance of IC in converting data-derived insights into innovative strategies, thereby contributing to improved competitiveness and the overall performance of the organization. This study is significant for manufacturing organisations and policymakers to make appropriate decisions regarding the usage of big data analytics. This study is limited to manufacturing organisations and selected variables. Future studies may use government policies as a moderator to test the model of current research.
Effects of ChatGPT on Students Academic Performance:Mediating Role of Prompt Engineering
Authors: Shehri Firdous Ahmed , Maham Raj , Malik Alia , Saif Osman Bin
Published: March 2024

This paper focuses on the use of advanced machine learning models, such as ChatGPT, in education. ChatGPT, a language learning model by OpenAI, has shown potential for reshaping education through enhanced teaching methods, increased student engagement, and personalised learning experiences. Despite these promising features, the potential drawbacks of the technology remain unclear. This paper seeks to examine the impacts of ChatGPT on students' academic performance, with a special emphasis on the role of 'prompt engineering' in this context. This research employs a quantitative method to examine the impact of ChatGPT on student academic performance in various universities across Pakistan. An online survey was distributed, garnering responses from 37 students at several institutions. The questions focused on demographic details and the impact of ChatGPT on academic performance parameters such as learning, quality of work, and creativity, with the role of prompt engineering as a mediating factor. Data was analysed using SPSS, with Cronbach's alpha used to ensure reliability and internal consistency of the responses, which showed a high degree of correlation among responses. The results indicated a positive relationship between the use of ChatGPT and academic performance (Naveed et al., 2023). However, while most students were aware of ChatGPT's capabilities, the majority did not use it for examination preparation. The study also found that prompt engineering played a mediating role between ChatGPT usage and student academic performance, highlighting the importance of effective prompt design in optimising the benefits of AI in educational settings.
Analyzing the Influence of Digital Currency Adoption on Traditional Banking Systems Through Data Analytics: A Study on Emerging Economies
Authors: Shabbir Javeria , Perveen Sobia , Dad Aasim Munir , Rehman Shafiq Ur , Ness Stephanie
Published: March 2024

This study delves into the ramifications of digital currency assimilation within traditional banking systems, with a specific emphasis on emerging economies, notably Pakistan. Motivated by the escalating prominence of digital currencies and their potential to disrupt conventional banking practices. The research formulates three hypotheses to scrutinize the interrelationships between digital currency adoption, technological infrastructure, regulatory frameworks, and the operational performance of conventional banks. Employing a structured questionnaire, disseminated amongst professionals in the banking and financial sector, as well as users of both digital currencies and traditional banking services, the investigation unfolds a nuanced understanding from diverse vantage points. The findings elucidate a positive correlation between heightened digital currency adoption and the enhanced performance of conventional banks. Additionally, a robust technological infrastructure and a conducive regulatory environment emerge as pivotal factors significantly shaping the performance of traditional banks in the milieu of digital currency adoption. These empirical results contribute substantively to the extant literature, underscoring the imperative for banks to acclimate to technological progressions and for policymakers to cultivate regulatory frameworks that strike a judicious balance between innovation and financial stability. While the study proffers valuable insights, it remains cognizant of its limitations in scope and propounds directions for future research, advocating for broader geographical representation and the exploration of other nascent technologies within the realm of finance.
Code Smell Detection and Software Refactoring Research: A Systematic Literature Review
Authors: Ali Israr , Rizvi Sajjad Hussain , Adil Syed Hasan , Abro Abdul Ahad
Published: March 2024

Today we are experiencing rapid enhancements in software systems and their development. The software industry's demand for tools and techniques for software development, especially automatic and less time-consuming, is increasing daily. Software refactoring and code smell detection are now expanded from code-level changes to the architecture, model, and requirements restructuring. We are moving from an object-oriented paradigm towards cloud computing, web development and mobile application development and so much more. Therefore, code smell and refactoring techniques are talk of the town in various research communities in their objectives. In this paper we will study the existing tools and techniques, research progress by doing a systematic literature review in the field of code smell detection and software refactoring’s. We will also classify the existing research techniques, identify the trends in code smell detection and refactoring and try to highlight the gaps in the area for researchers.
CRIISL: Convert Rasterize Image Into SVG Layers
Authors: Hassan Ahmed , Ebrahim Mansoor , Abro Abdul Ahad , Raza Kamran , Adil Syed Hasan
Published: March 2024

Raster images in multiple layers or vector format can be challenging for digital artists. However, converting them into Scalable Vector Graphics (SVG) format, such as Adobe Illustrator, Inkscape, or CorelDRAW, offers advantages. SVG files allow for easy resizing without loss of quality, making them ideal for creating logos, icons, and other graphics that need to be scaled to different sizes. They are lightweight and can be easily edited using code, providing more control over design elements. This versatile and flexible tool streamlines the design process and provides greater flexibility for artists in their creative projects. SVG files are smaller in size compared to raster images, making them easier to work with and share. Developers can also use code-based approaches to further manipulate and customize SVG images as needed.
Exploring the Role of Islamic FinTech Innovation Trialability and Compatibility in Enhancing Islamic Financial Inclusion: A Data-driven Approach
Authors: Rashid Hayat  , Waseem ul Hameed
Published: March 2024

The promotion of Islamic financial inclusion (IFI) is a challenge for Islamic banking industry in Pakistan. Although, Islamic banks are trying to enhance IFI, however, a satisfactory level is not achieved. Therefore, the objective of this study is to examine the role of trialability and compatibility in enhancing IFI. A questionnaire survey was preferred in this study to collected data from clients of Islamic banks in Punjab, Pakistan. 317 valid questionnaires were received and used to obtain findings. Structural Equation Modeling (SEM) was used through Smart PLS to test the study hypotheses. Findings of the study identified that trialability and compatibility has a positive role to promote IFI. Furthermore, compatibility has a positive effect on IFI, however, trialability does not influence IFI directly, it has indirect effect through Islamic FinTech adoption (IFA). Findings of the study provided various important insights for the policymakers to promote IFI.
HPV Vaccine Optimization Concerning Cervical Cancer
Authors: Yan Yan
Published: March 2024

Cervical cancer, associated with human papillomavirus (HPV), is currently the fourth most prevalent cancer among women in the world. Though nowadays there are HPV vaccines available on the market, more strategies need to be taken to improve them and develop more therapeutic vaccines. Recent research has mostly concentrated on the state of HPV vaccinations, including their mechanisms, clinical efficacy, and room for improvement. However, there is a significant research deficit in the field of therapeutic HPV vaccination development. This paper analyzes the mechanisms of both prophylactic and therapeutic HPV vaccines, analyzes the clinical efficacy of five major vaccines in China, and discusses strategies for optimizing HPV vaccines through adjuvants and targeted antigen design. This thorough analysis offers insightful perspectives on the efficacy and safety of the HPV vaccine and makes recommendations for further study and immunization campaigns. However, the problems about the impact of vaccination programs and HPV-related diseases in men haven’t been solved yet. Therefore, future studies should target developing therapeutic HPV vaccines, improving HPV vaccines in the next generation, increasing the awareness of the public, and increasing accessibility of vaccines to release the burden of cervical cancer globally.
Stem cell transplantation therapy for acute myeloid leukemia
Authors: Xu Sheng
Published: March 2024

Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy, presenting a significant challenge in the field of medicine. In this context, Hematopoietic Stem Cell Transplantation (HSCT) has garnered widespread attention as a potential therapeutic approach. This paper reviews the current research progress in the field of AML treatment, with a specific focus on the application of HSCT. Through a comprehensive analysis of recent literature and clinical trials, it systematically summarizes the therapeutic effects of HSCT in different patient populations. Despite demonstrating certain efficacy in AML treatment, there remain research gaps in the application of HSCT, particularly in specific patient groups and contexts. This paper extensively discusses the principles, types, and application scenarios of HSCT in AML patients. By reviewing recent research findings, this article analyzes the treatment outcomes of HSCT in both young and elderly patients and compares relevant survival data. This paper presents future prospects for research, including in-depth investigations into novel HSCT treatment strategies, the impact of age differences on treatment outcomes, and more. These prospects aim to provide more precise directions for improving the therapies for AML patients.
CRISPR Technology in Tumor Immunotherapy: Application, limitations, and Improvement Methods
Authors: Gao Shenghan , Miao Xuru , Liu Jiaqi
Published: March 2024

The CRISPR/Cas system is a natural immune mechanism present in prokaryotes, which protects itself by specifically cutting off viral DNA that invades the bacterial body. Under the research of scientists, CRISPR technology has developed into a powerful tool in tumor immunotherapy. It can reduce the inhibitory effect of tumor microenvironment on T cells and enhance tumor immunity by specifically knocking out genes at immune checkpoints (such as PD-1/CTLA-4) on T cells cultured in vitro. However, CRISPR technology also has significant limitations, with the main limitation being its off-target effect - CRISPR is prone to mistakenly identifying and cutting off genes similar to the target gene sequence, including the normal human genome. Once the off-target effect occurs, it will destroy normal genes other than the target gene and cause irreversible damage. Through research, it has been found that CRISPR combined with other technologies can effectively avoid off target effects and reduce treatment risks. This article elaborates on the specific mechanism of CRISPR technology combined with other technologies to avoid off target effects, and explores potential improvement methods.
mRNA Vaccines in Treatment Tumor: Advancement and Challenges
Authors: Cao Wen
Published: March 2024

Immunotherapy has become a well-known cancer treatment method recently. The expeditious development of COVID-19 vaccines has made the extensive use of messenger RNA (mRNA) vaccines possible, and strikingly increased research data have been devoted to exploiting the potential of mRNA vaccines as preclinical and clinical treatments for cancer. mRNA cancer vaccines can stimulate durable and targeted immune responses against tumor antigens (TAs). Despite the promising future of mRNA vaccines, some challenges remain, including mRNA instability and safety concerns. It is possible to improve mRNA's stability, translation efficiency, and immune-stimulating qualities by changing its components. Another main challenge facing the field of mRNA therapy is to improve the effectiveness delivery systems. This review begins with an introduction to the immunological mechanism underlying mRNA cancer vaccines. It then focuses on discussing the subject of improving the efficacy of mRNA cancer vaccines via two main approaches: optimization of mRNA structural and improvement of delivery system.
Integrating Bioinformatics in Cervical Cancer Research: A Comprehensive Review
Authors: Miao Runfei
Published: March 2024

In this comprehensive review, we delve into the transformative impact of bioinformatics in cervical cancer research, emphasizing its role in shifting from traditional clinical and pathological approaches to a nuanced molecular and genetic understanding. We explore the evolution of cervical cancer research, highlighting the pivotal transition marked by the identification of human papillomavirus (HPV) and the subsequent advancements in screening and vaccination. Central to this review is the elucidation of bioinformatics' contribution in identifying gene signatures, prognostic markers, and differentially expressed genes, along with the analysis of molecular pathways critical in the progression of cervical cancer. We also examine the methodological intricacies of bioinformatics, from data retrieval and preparation through differential gene expression analysis, to more sophisticated techniques like Gene Set Enrichment and Protein-Protein Interaction Network Analysis. Despite the significant strides made, we acknowledge the challenges in integrating bioinformatics findings into clinical practice and propose future directions towards personalized medicine. This review underscores the pivotal role of bioinformatics in enhancing our understanding of cervical cancer and paves the way for novel diagnostic and therapeutic strategies, ultimately aiming to improve patient care and survival rates.
The Effect of Bifidobacterium on Antibiotics and Its Impact on Infant Intestines
Authors: Xu Ruiyang
Published: March 2024

This study presents the benefits of Bifidobacterium longum in countering the negative effects of antibiotics, caesarean delivery, and formula feeding on infant gut microbiota. Antibiotics, often used post-caesarean to prevent infections, can impede the development of neonatal microbiota, reducing bacterial diversity and altering gut structure. The microbiota of caesarean-delivered infants exhibits less diversity, a problem that can be mitigated by probiotic supplementation. Breastfeeding, rich in human milk oligosaccharides (HMO), is shown to be critical for early gut flora compared to formula feeding, which lacks these beneficial components and delays microbiota maturation. Bifidobacterium longum, essential for infant gut health, adapts genetically to metabolize HMOs, promoting gut development and microbial cross-feeding, essential for producing health-promoting short-chain fatty acids (SCFAs). It repairs antibiotic-induced intestinal damage and helps maintain a balanced gut microbiota. Additionally, B. longum offers therapeutic potential for treating colitis and functional constipation in infants and may be an effective treatment for inflammatory bowel disease (IBD), fostering immune homeostasis and intestinal health recovery. The probiotic role of B. longum in early life could have lasting health implications.
Integration Methods and Advantages of Machine Learning with Cloud Data Warehouses
Authors: Li Hanzhe , Wang Xiangxiang , Feng Yuan , Qi Yaqian , Tian Jingxiao
Published: March 2024

A data warehouse is a subject-oriented, integrated, relatively stable collection of data that reflects historical changes and is used to support management decisions. Common tools for building a data warehouse are IBM Cognos and SAP BO. However, both of the above use centralized single-node mode to build data warehouses. This type of data warehouse has poor scalability, and due to the rapid increase in the scale of the Internet, traditional data warehouses can no longer meet the actual needs of use. This paper mainly introduces the integration of cloud data warehouse and machine learning as well as the importance and application of parallel integration methods. First, the paper describes how the combination of cloud data warehousing and machine learning can promote business innovation and increase output. It then discusses the challenges of managing machine learning models in production environments, and introduces the role of cloud data warehouses in addressing these challenges. Subsequently, the cloud computing integration of Snowflake, as well as the implementation steps and processes of the parallel integration approach are also introduced in detail. Finally, the results of parallel integration method are analyzed, and it is considered that it has a good application prospect and development potential in cloud data warehouse.
Literature Review: Exploring the Relationship Between Gender Cognition and Student Academics
Authors: Zhang Yichi
Published: March 2024

In the course of human history, discussion regarding gender differences and sexual roles has never come to an end. In present-day society, cultural influences, together with the “discovered” physiological differences, have contributed to severe gender inequalities and bias that can be perceived in all aspects. Under this distressing situation, education should be an important aspect that must be paid attention to as it is a determining factor of societal development. Based on empirical research, it really should be concerned that the often biased gender cognition may have potentially contributed to educational impairment, for which the disparate attitudes, opinions, and assumptions that people hold about the two genders, based on sufficient empirical research, have strongly influenced students’ academic performance and have further facilitated the formation of inequalities in future learning opportunities, career path, etc.; it is fair to say that these series of connections have gradually formed a negative feedback loop worsening the current inequality situation. This paper will focus primarily on finding the connections between the tendentious beliefs on gender cognition and students’ academics; specifically, empirical research papers regarding how people’s gender cognition may affect different aged students’ academic performance and self-concepts at schools will be reviewed to look for possible relationships.
Research on the Present Situation and Cultivation Strategy of Children's Social Communication Ability from the Perspective of Family-Kindergarten Coeducation
Authors: Yu Zhuoying
Published: March 2024

Family and kindergarten are the most vital places for children's life and education. Only by implementing family-kindergarten coeducation can we create a better growing environment for children and empower their peer communication. This study found three main problems, including children's poor peer communication ability, parents' insufficient sense of responsibility, and the severely limited development of family-kindergarten coeducation. Based on the above problems, this study puts forward that teachers should conduct targeted guidance according to the social communication needs of children in different age classes. Parents should improve their educational awareness and scientifically guide children to establish correct communication concepts. Meanwhile, kindergarten takes a dual approach to break through the communication barriers of family-kindergarten coeducation.
Analysis of the “Hole” in Invisible Man based on Plato’s Cave Allegory
Authors: Weng Jiajie
Published: March 2024

Ralph Ellison’s novel Invisible Man mentions a “hole” the nameless black young man lives in. Telling the story of himself, the invisible man showed readers his transition from hibernating in the “hole” to walking out of the “hole”, which reflects his journey of seeking an effective solution for black people to fit into society. Based on Plato’s Cave Allegory, this paper analyzes how four phases in the invisible man’s journey of seeking the “truth” correspond to the phases in the Cave Allegory. Meanwhile, this paper attempts to analyze the “hole” metaphor, the “truth” that repeatedly appears, and different characters in this book to appreciate the author’s unique intention in using the “hole” metaphor.
The role of ELISA in the diagnosis of Alzheimer’s disease
Authors: Ye Jiaer
Published: March 2024

As the world population ages, Alzheimer’s disease (AD) has emerged as a significant public health issue. The regulatory measures, clinical strategies, and even the scientific communications regarding AD all rely on the advancements in uncovering AD pathology, and the ability to recapitulate the disease-relevant players in a “gestalt” and clinically-applicable manner. Neurologists have sought to post mortem validation of AD pathologies (amyloid plaques and neurofibrillary tangles) in brain tissues; gradually, the weight is shifted to the detection of biological measures in the hope of diagnosing AD in its early phase before irreversible cognitive deterioration. Technologies that enable such early diagnosis or even prevention of AD, such as the enzyme-linked immunosorbent assay (ELISA), are emerging to obtain increasingly bigger roles in this field. Increasing the sensitivity and accuracy through enhancing the original ELISA with novel agents (nanoparticles as colorization agents etc) or improved protocols were the main approaches used. However, ELISA is also important as a lab staple, especially for the quantification of key AD biomolecules such as Ab42. ELISA connotates a more profound theme and future prospect of AD research: the entangling of biosensors development and the continued effort in deciphering of a more holistic map of AD.
Research on the Innovative Design of "Pan Wang Seal" Pattern of Yao Nationality in Northern Guangdong
Authors: Guan Huilin , Wang Lizhi
Published: March 2024

As one of the national intangible cultural heritages, "Panwang Seal" pattern is a typical symbol of Yao nationality. It has various forms, bright colors and profound cultural connotation. It has special decorative significance and high research value. It is of great significance to persist, develop and carry forward the excellent traditional culture of Yao nationality by deeply exploring the connotation and style characteristics of Yao nationality's "Panwang seal" pattern in northern Guangdong. "Panwang Seal" pattern provides rich materials and inspiration for modern pattern design, and researches and develops the patterns of Yao nationality in northern Guangdong, while protecting and spreading the national culture.
PENGARUH MOTIVASI DAN BUDAYA ORGANISASI TERHADAP KINERJA KARYAWAN MELALUI KEPEMIMPINAN PADA PT SWADHARMA SARANA INFORMATIKA
Authors: Rahardi Dedi Rianto , Permatasari Aena Luthfiyani , Nandaika Alfina , Anisa Noviyanti
Published: March 2024

This study investigates the effects of leadership and organizational culture on employee motivation within PT. Swadharma Sarana Informatics, with organizational performance considered an intermediary factor. Employing quantitative research methods, the study aims to quantify the interrelations among these variables. Data collection involved distributing questionnaires to 100 randomly selected civil servants at PT. Swadharma Sarana Informatics. SmartPls 3.0 software was used for data analysis. Initial findings suggest that organizational culture negatively impacts organizational performance but positively influences employee motivation at PT. Swadharma Sarana Informatics. Leadership shows a positive and significant effect on organizational performance within the organization. However, it does not significantly influence employee motivation.Additionally, organizational performance does not significantly impact employee motivation. Furthermore, organizational performance does not act as an intermediary factor between leadership and motivation, nor between organizational culture and motivation within PT. Swadharma Sarana Informatics