bluuebunny/crossref_metadata_2025 huggingface dataset:
Primitive divisors of sequences associated to elliptic curves with complex multiplication
Authors: Verzobio Matteo
Published: May 2021

Let P and Q be two points on an elliptic curve defined over a number field K. For $$\alpha \in {\text {End}}(E)$$

α
∈
End
(
E
)

, define $$B_\alpha $$

B
α

to be the $$\mathcal {O}_K$$

O
K

-integral ideal generated by the denominator of $$x(\alpha (P)+Q)$$

x
(
α
(
P
)
+
Q
)

. Let $$\mathcal {O}$$
O
be a subring of $${\text {End}}(E)$$

End
(
E
)

, that is a Dedekind domain. We will study the sequence $$\{B_\alpha \}_{\alpha \in \mathcal {O}}$$

{

B
α

}

α
∈
O

. We will show that, for all but finitely many $$\alpha \in \mathcal {O}$$

α
∈
O

, the ideal $$B_\alpha $$

B
α

has a primitive divisor when P is a non-torsion point and there exist two endomorphisms $$g\ne 0$$

g
≠
0

and f so that $$f(P)= g(Q)$$

f
(
P
)
=
g
(
Q
)

. This is a generalization of previous results on elliptic divisibility sequences.
Complete chiral resolution in a continuous flow crystallizer with recycle stream
Authors: Neugebauer Peter , Triebl Andrea , Gruber-Woelfler Heidrun
Published: May 2021

Repeated temperature cycling of crystals from a conglomerate forming chiral substance suspended in their saturated solution has shown to be effective in converting a mixture of both enantiomers into an enantiomerically pure state. While by now a large number of different setups has been demonstrated, here we show for the first time how a continuous flow temperature cycler with recycle stream is capable of establishing enantiopurity while converting a racemic starting suspension. By capturing the most significant parameters influencing the process kinetics a competitive productivity could be achieved. We show, that fast crystal dissolution at high undersaturations and fast crystal growth at high supersaturations are speeding up the process as long as nucleation can be kept to a minimum or avoided at all. Temperature cycling has shown to result in a shift towards larger sizes for the particle size distribution of the crystals suspended, which is detrimental to the present process governed by size-dependent solubility. By implementing an ultrasound unit recycled material was comminuted, resulting in nearly stable deracemization rates.

Graphical abstract
Actuation Technologies for Soft Robot Grippers and Manipulators: A Review
Authors: Zaidi Shadab , Maselli Martina , Laschi Cecilia , Cianchetti Matteo
Published: May 2021

Purpose of Review

The new paradigm of soft robotics has been widely developed in the international robotics community. These robots being soft can be used in applications where delicate yet effective interaction is necessary. Soft grippers and manipulators are important, and their actuation is a fundamental area of study. The main purpose of this work is to provide readers with fast references to actuation technologies for soft robotic grippers in relation to their intended application.

Recent Findings

The authors have surveyed recent findings on actuation technologies for soft grippers. They presented six major kinds of technologies which are either used independently for actuation or in combination, e.g., pneumatic actuation combined with electro-adhesion, for certain applications.

A review on the latest actuation technologies for soft grippers and manipulators is presented. Readers will get a guide on the various methods of technology utilization based on the application.
Molecular Peritoneal Staging for Pancreatic Ductal Adenocarcinoma Using Mutant KRAS Droplet-Digital Polymerase Chain Reaction: Results of a Prospective Clinical Trial
Authors: Yonkus Jennifer A. , Alva-Ruiz Roberto , Abdelrahman Amro M. , Leiting Jennifer L. , Schneider Amber R. , Grotz Travis E. , Cleary Sean P. , Smoot Rory L. , Nagorney David M. , Kendrick Michael L. , Kipp Benjamin R. , Truty Mark J.
Published: May 2021

BACKGROUND:

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with predilection for peritoneal dissemination. Accurate peritoneal staging is imperative for treatment recommendations, as one-third of patients develop peritoneal recurrence after resection. Because >90% of PDAC tumors harbor mutant KRAS (mKRAS), we sought to determine feasibility of mKRAS DNA detection in peritoneal lavage (PL) fluid using droplet-digital polymerase chain reaction (ddPCR) via a prospective trial.

STUDY DESIGN:

Patients with nonmetastatic PDAC undergoing staging laparoscopy with PL were included. PL fluid was sent for cytologic examination, CA19-9/CEA levels, and mKRAS ddPCR assay. Clinically positive laparoscopy was defined as gross metastases or positive cytology. PL mKRAS status was compared with gross findings, cytology, and CA19-9/CEA levels.

RESULTS:

There were 136 patients enrolled; 70 of 136 (51%) patients received neoadjuvant therapy before PL, and 32 of 136 (24%) patients had clinically positive laparoscopy. Cytology was positive in 17 of 136 (13%) patients, and 22 of 136 (16%) patients had gross metastases. Of patients with gross metastases, only 8 of 22 (36%) had positive cytology; 97 of 136 (71%) patients had mKRAS in PL. PL mKRAS was present in 27 of 32 (84%) clinically positive laparoscopies, with higher mean copy number in clinically positive patients (643 vs 10, p = 0.02). Peritoneal mKRAS was positive in an additional 70 clinically negative patients.

CONCLUSIONS:

This prospective study establishes the feasibility of PL mKRAS detection. Clinically positive disease was identified in 1 in 4 staging laparoscopies. Although PL mKRAS was highly associated with clinically positive findings, many clinically negative laparoscopies had detectable PL mKRAS, suggesting that standard staging may be inadequate. Longer follow-up will elucidate utility of this promising molecular assay.
A First Course in Laboratory Optics
Authors: Gretarsson Andri M.
Published: May 2021

An optics experiment is the product of intricate planning and imagination, best learned through practice. Bringing forth the creative side of experimental physics through optics, this book introduces its readers to the fundamentals of optical design through seven key experiments. The book includes several topics to support readers preparing to enter industrial or academic research laboratories. Optical sources, model testing and fitting, noise, geometric optics, optical processes such as diffraction, interference, polarization, and optical cavities, are just some of the key topics included. Coding tutorials are provided in the book and online to further develop readers' experience with design and experimental analysis. This guide is an invaluable introduction to the creative and explorative world of laboratory optics.
International Jewish Humanitarianism in the Age of the Great War
Authors: Granick Jaclyn
Published: May 2021

In 1914, seven million Jews across Eastern Europe and the Eastern Mediterranean were caught in the crossfire of warring empires in a disaster of stupendous, unprecedented proportions. In response, American Jews developed a new model of humanitarian relief for their suffering brethren abroad, wandering into American foreign policy as they navigated a wartime political landscape. The effort continued into peacetime, touching every interwar Jewish community in these troubled regions through long-term refugee, child welfare, public health, and poverty alleviation projects. Against the backdrop of war, revolution, and reconstruction, this is the story of American Jews who went abroad in solidarity to rescue and rebuild Jewish lives in Jewish homelands. As they constructed a new form of humanitarianism and re-drew the map of modern philanthropy, they rebuilt the Jewish Diaspora itself in the image of the modern social welfare state.
Tunisia's Modern Woman
Authors: Kallander Amy Aisen
Published: May 2021

Claims over women's liberation vocalized by Tunisia's first president, Habib Bourguiba began with legal reforms related to family law in 1956. In this book, Amy Aisen Kallander uses this political appropriation of women's rights to look at the importance of women to post-colonial state-building projects in Tunisia and how this relates to other state-feminist projects across the Middle East and during the Cold War. Here we see how the notion of modern womanhood was central to a range of issues from economic development (via family planning) to intellectual life and the growth of Tunisian academia. Looking at political discourse, the women's press, fashion, and ideas about love, the book traces how this concept was reformulated by women through transnational feminist organizing and in the press in ways that proposed alternatives to the dominant constructions of state feminism.
Pandora’s box in the dental clinic
Authors: Ben-David Debby , Vaturi Azza , Solter Ester , Rubinovitch Bina , Lellouche Jonathan , Schwartz David , Schechner Vered , Carmeli Yehuda , Schwaber Mitchell J.
Published: May 2021

Background:

In June 2018, the Ministry of Health received notification from 2 hospitals about 2 patients who presented with overwhelming Enterobacter kobei sepsis that developed within 24 hours after a dental procedure. We describe the investigation of this outbreak.

Methods:

The epidemiologic investigation included site visits in 2 dental clinics and interviews with all involved healthcare workers. Chart reviews were conducted for case and control subjects. Samples were taken from medications and antiseptics, environmental surfaces, dental water systems, and from the involved healthcare professionals. Isolate similarity was assessed using repetitive element sequence-based polymerase chain reaction (REP-PCR).

Results:

The 2 procedures were conducted in different dental clinics by different surgeons and dental technicians. A single anesthesiologist administered the systemic anesthetic in both cases. Cultures from medications, fluids and healthcare workers’ hands were negative, but E. kobei was detected from the anesthesiologist’s portable medication cart. The 2 human isolates and the environmental isolate shared the same REP-PCR fingerprinting profile. None of the 21 patients treated by the anesthesiologist in a general hospital during the same period, using the hospital’s medications, developed infection following surgery.

Conclusions:

An outbreak of post–dental-procedure sepsis was linked to a contaminated medication cart, emphasizing the importance of medication storage standards and strict aseptic technique when preparing intravenous drugs during anesthesia. Immediate reporting of sepsis following these outpatient procedures enabled early identification and termination of the outbreak.
Ice thickness distribution of all Swiss glaciers based on extended ground-penetrating radar data and glaciological modeling
Authors: Grab Melchior , Mattea Enrico , Bauder Andreas , Huss Matthias , Rabenstein Lasse , Hodel Elias , Linsbauer Andreas , Langhammer Lisbeth , Schmid Lino , Church Gregory , Hellmann Sebastian , Délèze Kevin , Schaer Philipp , Lathion Patrick , Farinotti Daniel , Maurer Hansruedi
Published: May 2021

Accurate knowledge of the ice thickness distribution and glacier bed topography is essential for predicting dynamic glacier changes and the future developments of downstream hydrology, which are impacting the energy sector, tourism industry and natural hazard management. Using AIR-ETH, a new helicopter-borne ground-penetrating radar (GPR) platform, we measured the ice thickness of all large and most medium-sized glaciers in the Swiss Alps during the years 2016–20. Most of these had either never or only partially been surveyed before. With this new dataset, 251 glaciers – making up 81% of the glacierized area – are now covered by GPR surveys. For obtaining a comprehensive estimate of the overall glacier ice volume, ice thickness distribution and glacier bed topography, we combined this large amount of data with two independent modeling algorithms. This resulted in new maps of the glacier bed topography with unprecedented accuracy. The total glacier volume in the Swiss Alps was determined to be 58.7 ± 2.5 km3 in the year 2016. By projecting these results based on mass-balance data, we estimated a total ice volume of 52.9 ± 2.7 km3 for the year 2020. Data and modeling results are accessible in the form of the SwissGlacierThickness-R2020 data package.
The Italian coffee triangle: From Brazilian colonos to Ethiopian colonialisti
Authors: Garvin Diana
Published: May 2021

This article investigates the history of coffee culture across three continents during the Fascist ventennio (1922–45.) By using the novel framework of coffee, from the bean in the field to the machine in the caffè, it connects interwar histories that previously have been explored independently. Specifically, it examines the transnational economics of coffee bean trade routes and the colonial imagery of coffee advertising to argue that caffès emerged as key sites for promoting the Fascist imperial projects in East Africa – an architectural and artistic legacy that remains in place today. Ultimately, this trajectory broadens the way that we understand how food and farming became politicised during the Fascist period. By untangling the interwar trade of beans and bodies between Italy, Brazil, and Ethiopia, this article brings to light an untold story of caffeinated imperial aggression and resistance.
Ultrafast enzymatic digestion of deoxyribonucleic acid in aqueous microdroplets for sequence discrimination and identification
Authors: Zhong Xiaoqin , Chen Hao , Zare Richard N.
Published: May 2021

We report the use of aqueous microdroplets to accelerate deoxyribonucleic acid (DNA) fragmentation by deoxyribonuclease I (DNase I), and we present a simple, ultrafast approach named DNA fragment mass fingerprinting to discriminate different DNA sequences by comparing their fragment mass patterns. DNA fragmentation in tiny microdroplets, which was produced by electrosonically spraying (+3 kV) a room temperature aqueous solution containing 10 μM DNA and 10 μg ml−1 DNase I from a homemade setup, takes less than 1 ms. High differentiation/identification fidelity could be obtained by applying a cosine correlation measure for similarity assessment between two fragment mass patterns, which compares both mass-to-charge ratios (m/z) with an error tolerance of 5 ppm and the peaks’ relative intensities. A single-nucleotide mutation in the sequence of bases, as exemplified by the sickle cell anemia mutation, is differentiated by setting a cutoff value of similarity at 90%. The order change of two adjacent bases in the sequence could still be well discriminated with a similarity of only 62% between the fragment mass patterns of the two similar sequences, which have the same molecular weights and thus cannot be differentiated by gel electrophoresis or direct mass detection by mass spectrometry. Compared to traditional genotyping methods, such as quantitative real-time polymerase chain reaction, the identification process with our approach could be completed within several minutes without any other expensive and complicated reagents or experimental steps. The potential of our approach for convenient and fast microbe genetic discrimination or identification is further demonstrated by differentiating the Orf1ab gene fragments of two similar coronaviruses with a very high sequence homologous rate of 96%, SARS-CoV-2 and bat-SL-CoVZC45, with a similarity of 0% between their fragment mass patterns.
Representation and Presence: Divine Names in Judaism and Islam
Authors: Ben-Sasson Hillel
Published: May 2021

Divine names are linguistic objects that underlie the grammar of religious language. They serve as both representations and presentations of the divine. As representations, divine names carry information pertaining to God’s nature or actions, and his unique will, in a manner that adequately represents him. As presentations, divine names are believed to somehow effect divine presence in proximity to the believer, opening a path of direct connection to God. This paper seeks to analyze the interaction between presentation and representation concerning divine names in major trends within Judaism and Islam, from the Hebrew Bible and the Qur’an to medieval theological debates. It aims to demonstrate how central currents within both traditions shaped the intricate relation between divine presentation and representation through the prism of divine names. Whereas positions in philosophy of language focus on either the representational or the presentational functions of proper names, Jewish and Islamic theologies suggest ways to combine the two functions with regard to divine names.
Experiences of stigma and discrimination among people living with dementia and family carers in Brazil: qualitative study
Authors: Oliveira Déborah , Da Mata Fabiana Araújo Figueiredo , Mateus Elaine , Musyimi Christine W. , Farina Nicolas , Ferri Cleusa P. , Evans-Lacko Sara
Published: May 2021

This study aimed to understand stigma in relation to people living with dementia in São Paulo, Brazil. A critical narrative inquiry methodology was used. Home-based semi-structured interviews were conducted between January and March 2020 with six people living with dementia and 15 family carers. Data analysis was conducted using inductive and deductive techniques. The latter was informed by Link and Phelan's sociological theory of stigma. We found that dementia was commonly viewed by people living with dementia as part of ageing and carers reported low levels of knowledge and awareness about the condition. To avoid negative reactions from people, people living with dementia managed the negative views of dementia by minimising and normalising the condition, by expressing their ability to live an active life, and by emphasising the positive impacts of dementia in their lives. Fear of negative reactions appeared to lead to a selective disclosure of their diagnosis. Among carers, stigmatising attitudes coincided with a strong willingness to provide good care, to protect the person cared for, as well as to understand and validate their own caring experiences, rather than to cause any harm. In doing so, however, carers ended up depersonalising and infantilising people living with dementia, underestimating their capacities, demanding ‘obedience’ and restricting the person's freedom. There is a need to increase awareness about dementia and to provide support and training on person-centred and ethical care for carers in Brazil.
Input effects in the acquisition of verb inflection: Evidence from Emirati Arabic
Authors: SZREDER Marta , DE RUITER Laura E. , NTELITHEOS Dimitrios
Published: May 2021

This study investigates the acquisition of the Imperfective verb inflection paradigm in Emirati Arabic (EA), to determine whether the learning process is sensitive to the phonological and typological properties of the input. We collected data from 48 participants aged 2;7 to 5;9 years, using an elicited production paradigm. Input frequencies of inflectional contexts, verb types and tokens were obtained from corpora of child-directed and adult EA. Children's accuracy was inversely related to the input frequency of inflectional contexts, but not related to type and token frequency or phonological neighborhood density. Token frequency interacted with age, such that younger children performed considerably worse on low-frequency tokens, but older children performed equally well on high- and low-frequency tokens. We conclude that learning is input-driven, but that a sufficiently regular paradigm allows children to eventually generalise across all items earlier than in previously studied European languages.
Maternal and paternal unsupportive parenting and children's externalizing symptoms: The mediational role of children's attention biases to negative emotion
Authors: Davies Patrick T. , Thompson Morgan J. , Coe Jesse L. , Sturge-Apple Melissa L.
Published: May 2021

This study examined children's duration of attention to negative emotions (i.e., anger, sadness, fear) as a mediator of associations among maternal and paternal unsupportive parenting and children's externalizing symptoms in a sample of 240 mothers, fathers, and their preschool children (Mage = 4.64 years). The multimethod, multi-informant design consisted of three annual measurement occasions. Analysis of maternal and paternal unsupportive parenting as predictors in latent difference changes in children's affect-biased attention and behavior problems indicated that children's attention to negative emotions mediated the specific association between maternal unsupportive parenting and children's subsequent increases in externalizing symptoms. Maternal unsupportive parenting at Wave 1 predicted decreases in children's attention to negative facial expressions of adults from Wave 1 to 2. Reductions in children's attention to negative emotion, in turn, predicted increases in their externalizing symptoms from Wave 1 to 3. Additional tests of children's fearful distress and hostile responses to parental conflict as explanatory mechanisms revealed that increases in children's fearful distress reactivity from Wave 1 to 2 accounted for the association between maternal unsupportive parenting and concomitant decreases in their attention to negative emotions. Results are discussed in the context of information processing models of family adversity and developmental psychopathology.
“An Unacceptable Surrender of Fiscal Sovereignty”: The Neoliberal Turn to International Tax Arbitration
Authors: Hearson Martin , Tucker Todd N.
Published: May 2021

The growth of inequality over the past half century is closely connected to the rise of neoliberal policies and institutions, the latter of which shield capital from state actions that might limit wealth accumulation. Economic nationalism since the global financial crisis has slowed or even reversed this, yet this same era has seen the emergence of a new form of instrument in the neoliberal mold, in a stronghold of state sovereignty: taxation. Under mandatory binding tax arbitration, states cede sovereignty over the interpretation of international tax agreements to panels of transnational tax adjudicators. Focusing on the pivotal role of the United States, we use historical documents, including from the congressional archive and interviews with key actors to ask why tax arbitration emerged late in the neoliberal era, and at a counterintuitive time. We demonstrate that this outcome is the result of instrumental business power driving a process of incremental change through layering, to overcome states’ preference to retain sovereignty. This experience sheds light on the historically structured ways that business power constrains sovereignty in an era of high inequality.
Late-seeded cover crops in a semiarid environment: overyielding, dominance and subsequent crop yield
Authors: Hendrickson John R. , Liebig Mark A. , Archer David W. , Schmer Marty R. , Nichols Kristine A. , Tanaka Donald L.
Published: May 2021

Interest in cover crops is increasing but information is limited on integrating them into crop rotations especially in the relatively short growing season on the northern Great Plains. A 3-yr research project, initiated in 2009 near Mandan, North Dakota, USA, evaluated (1) what impact cover crops may have on subsequent cash crops yields and (2) whether cover crop mixtures are more productive and provide additional benefits compared to cover crop monocultures. The study evaluated 18 different cover crop monocultures and mixtures that were seeded in August following dry pea (Pisum sativum L.). The following year, spring wheat (Triticum aestivum L.), corn (Zea mays L.), soybean (Glycine max L.) and field pea were seeded into the different cover crop treatments and a non-treated control. A lack of timely precipitation in 2009 resulted in a low cover crop yield of 17 g m2 compared to 100 and 77 g m2 in 2008 and 2010, respectively. Subsequent cash crop yield was not affected by late-seeded cover crops. Cool-season cover crop monocultures were more productive than warm-season monocultures and some mixtures in 2008 and 2010. Relative yield total did not differ from one in any cover crop mixture suggesting that overyielding did not occur. Species selection rather than species diversity was the most important contributor to cover crop yield. Cover crops can be grown following short-season cash crops in the northern Great Plains, but precipitation timing and species selection are critical.
Private actors in development projects: reflections on human rights between power and resistance
Authors: Erdem Türkelli Gamze
Published: May 2021

The theme of the book symposium ‘The Rule of Law in Transnational Development Projects’ is, as Bhatt's Concessionaires, Financiers and Communities (2020) and Lander's Transnational Law and State Transformation (2020) highlight, ripe for critical reflection. The two books reveal the power wielded by private for-profit actors in the co-constitution of legal norms, often at the expense of local communities in development-investment settings. The co-constitution of legal norms by private actors via ‘contracts’, ‘policies’ and ‘intermediaries’ (Bhatt, Lander and Taekema, Book Symposium Introduction in this issue) development permeates rule of law in the public sphere, including in ways that affect the application of domestic and international legal norms relating to human rights. Of course, rule of law may be defined by ‘thick’ conceptions … as a just system of laws ‘consistent with international human rights norms and standards’ (UN Secretary General, 2004, para. 6) or ‘thin’ conceptions with more formalistic requirements that do not prescribe political or social values. Deontological questions aside, even in its ‘thinnest’ conception, rule of law means that legal norms ‘should be publicly promulgated; be predictable in their application; apply to all citizens, including government officials; and be subject to some form of neutral adjudication in the event of disputes as to their interpretation or application’ (Trebilcock, 2011, p. 209). Yet, rule of law has often been applied ‘to favour entrenched elites over resistance groups, vested interests … over civil disobedience, official actors over unofficial actors and property owners over protestors’ (Simpson, 2012, p. 9).
‘Choking the national demos’: research partnerships and the material constitution of global health
Authors: Harrington John
Published: May 2021

By foregrounding a widened view of the rule of law in transnational legal processes, the works under discussion in this symposium can support innovative critical perspectives on global health law –a field that has gained wide attention due to the spread of COVID-19 around the world (Lander, 2020; Bhatt, 2020). Legal and socio-legal scholars in the decade and a half before the pandemic worked on locating global health law and articulating its underlying principles. Lawrence Gostin's 2014 monograph offers a synoptic view centred on international institutions (e.g. the World Health Organization, World Trade Organization, UN Human Rights Council) and problems (e.g. infectious-disease response, tobacco control), along with an elaboration of its normative basis in universal moral principle and international human rights law (Gostin, 2014). Struggles over access to essential medicines and intellectual property in the early 2000s are, for example, represented in terms of the right to health constraining international trade law. Andreas Fischer-Lescano and Guenther Teubner's 2004 reading is oriented more by social theory than by doctrinal or ethical frames (Fischer-Lescano and Teubner, 2004, pp. 1006, 1008). A functional health regime has ‘differentiated out’, they observe, and operates as a discrete communication system across borders, albeit one that is threatened by the preponderant economic system. On this model, the battle for access to medicines amounts to ensuring, via human rights guarantees, that the rationality of the health system is not replaced by that of its economic rival in legal and policy communications (Fischer-Lescano and Teubner, 2004, pp. 1030, 1046).
Access to remedy in transnational development projects: the need for effective and comprehensive remedy ecosystems
Authors: Scheltema Martijn
Published: May 2021

It is observed in the Introduction of this special issue that the rule of law has been an integral part of the development of democratic systems of government in national states and features powerfully within contemporary ‘good-governance’ promotion in the Global South by development financial institutions (DFIs). However, the rule of law is predominantly used to emphasise the importance of stability of contract and protection of property in connection with transnational development projects (TDPs) and does not so much focus on the general stability of (e.g. indigenous) rights, access to justice and fairness. Thus, it is important to deviate from a narrow interpretation of the rule of law and include the role of all types of actors in safeguarding this rule of law.
Post-colonial attitudes and the relevance of incommensurability
Authors: Darian-Smith Eve
Published: May 2021

This paper reflects upon the enduring relevance of Peter Fitzpatrick's analysis of incommensurability in the context of post-colonialism and the lived experiences of Indigenous peoples in the US.
Ocean Surface Wind Speed Dependence and Retrieval From Off‐Nadir CFOSAT SWIM Data
Authors: Ren L. , Yang J. , Xu Y. , Zhang Y. , Zheng G. , Wang J. , Dai J. , Jiang C.
Published: May 2021

In this study, we analyzed the ocean surface wind speed dependence of off‐nadir data from the Surface Waves Investigation and Monitoring (SWIM) aboard the Chinese‐French Oceanography Satellite (CFOSAT). When the data were analyzed, the SWIM normalized radar cross section (NRCS) at most incidence angles decreased along the NCEP Global Forecast System wind speed. This trend is consistent with that in a Ku‐band geophysical model function at low incidence angles (KuLMOD2S), although there was a systematic bias between the two. The consistency indicates that the SWIM data quality was normal in terms of wind speed dependence. The bias was recalibrated using a numerical weather prediction‐based ocean calibration method and the wind speeds were retrieved from the recalibrated NRCS data using the KuLMOD2S model. Finally, the retrievals at off‐nadir as well as the wind products at nadir were validated using collocated CFOSAT scatterometer (CSCAT) wind measurements. When the results were validated, the retrievals at 0.5° were consistent with the averaged wind products at nadir and both had a root mean square difference (RMSD) around 1.4 m/s compared to the CSCAT winds. Moreover, the winds retrieved from the SWIM data at most incidence angles were in good agreement with the CSCAT winds,and the RMSD values were within 2.0 m/s for incidence angles less than 7.5°, although the retrieval accuracy was poor at larger incidence angles. These results demonstrate that the SWIM data at incidence angles below 7.5° have an ability to retrieve the wind speed.
Controls on the Spatial Distribution of Near‐Surface Pyrogenic Carbon on Hillslopes 1 Year Following Wildfire
Authors: McGuire Luke A. , Rasmussen Craig , Youberg Ann M. , Sanderman Jonathan , Fenerty Brendan
Published: May 2021

Wildfire alters hydrologic and geomorphic systems, promoting increases in runoff and erosion relative to unburned areas. As a result, pyrogenic carbon (PyC) produced by wildfires can experience substantial lateral redistribution from overland flow. Since landscape position helps to determine the fate of PyC, it is critical to understand the geomorphic factors that govern its lateral redistribution as well as the sensitivity of those factors to soil burn severity, which controls the magnitude of many wildfire‐induced hydrologic and geomorphic changes. In this study, we quantified the spatial distribution of near‐surface (0–5 cm) PyC on three hillslopes roughly 1 year after the 2018 Buzzard Fire in the Gila National Forest, New Mexico, USA. We then use hydrologic monitoring data, terrain analysis, and rainfall‐runoff modeling to explain the observed spatial distribution of PyC. Near‐surface PyC concentrations decreased from averages of roughly 12–8 g/kg as slope and unit stream power increased by factors of ∼2 and 4, respectively, on a hillslope burned at low severity. This suggests that susceptibility to runoff‐driven erosion was a dominant control on the redistribution of PyC. In contrast, the spatial distribution of PyC in areas burned at moderate to high severity was independent of slope and unit stream power. We attribute this pattern to intense runoff and lack of canopy cover, which promoted erosion of PyC regardless of slope and landscape position. Results demonstrate that how wildfire‐induced hydrogeomorphic changes can modulate the importance of terrain attributes in controlling the spatial distribution of PyC in upland landscapes.
Intraseasonal Variability of Sea Level in the Western North Pacific
Authors: Liu Haolang , Feng Xiangbo , Tao Aifeng , Zhang Wei
Published: May 2021

Sea levels in the Western North Pacific (WNP) are presented with anomalous intraseasonal variations. This study examines the response of sea level in the WNP to the atmospheric Intraseasonal Oscillation modes, namely the Madden–Julian Oscillation (MJO) and the Boreal Summer Intraseasonal Oscillation (BSISO), using the 25 years (1993–2017) of satellite altimetry and barotropic model output. In winter, the MJO has significant effects on the component of sea level due to the instant wind and atmospheric pressure effects (high‐frequency), showing an eastward propagation pattern in most regions, with the strongest effects in the western marginal seas. The MJO‐associated pattern of dynamical (low‐frequency) component of sea level propagates southward, with the significant effects mostly in the tropics. In summer, the BSISO‐associated pattern of the high‐frequency component of sea level moves from southwest to northeast, with the largest anomalies in the middle of WNP (20°N‐30°N), while the strongest BSISO effects on the low‐frequency component are detectable mostly in the coasts of China and east of the Philippines. The MJO and BSISO can also modulate the probability of extreme sea level events. In winter, during phases 2–5, MJO increases the chance of extreme high events in the high‐frequency component of sea level by 100%–200% in the western coasts and the tropics. In summer, in BSISO phases 6–7, the chance of extreme high events in the high‐frequency component of sea level is enhanced by >300% in the South China Sea and east of the Philippines.
Topographic and Geologic Controls on Frost Cracking in Alpine Rockwalls
Authors: Draebing Daniel , Mayer Till
Published: May 2021

Frost weathering is a major control on rockwall erosion in Alpine environments. Previous frost cracking model approaches used air temperatures as a proxy for rock temperatures to drive frost weathering simulations on rockwall and on mountain scale. Unfortunately, the thermal rockwall regime differs from air temperature due to topographic effects on insolation and insulation, which affects frost weathering model results and the predicted erosion patterns. To provide a more realistic model of the rockwall regime, we installed six temperature loggers along an altitudinal gradient in the Swiss Alps, including two logger pairs at rockwalls with opposing aspects. We used the recorded rock surface temperatures to model rock temperatures in the upper 10 m of the rockwalls and as input data to run four different frost cracking models. We mapped fracture spacing and rock strength to validate the model results. Our results showed that frost cracking models are sensitive to thermal, hydraulic and mechanical parameters that affect frost cracking magnitude but frost cracking patterns in terms of peak location and affected rock mass remained consistent between varying input parameters. Thermo‐mechanical models incorporate rock strength and hydraulic properties and provided a frost cracking pattern at the rockwall scale that better reflects the measured fracture spacing. At the mountain scale, these models showed a pattern of increasing frost cracking with altitude, which is contrary to purely thermal models but consistent with observations of existing rockfall studies.
The interaction between the gut microbiota and dietary carbohydrates in nonalcoholic fatty liver disease
Authors: Park Grace , Jung Sunhee , Wellen Kathryn E. , Jang Cholsoon
Published: May 2021

Imbalance between fat production and consumption causes various metabolic disorders. Nonalcoholic fatty liver disease (NAFLD), one such pathology, is characterized by abnormally increased fat synthesis and subsequent fat accumulation in hepatocytes1,2. While often comorbid with obesity and insulin resistance, this disease can also be found in lean individuals, suggesting specific metabolic dysfunction2. NAFLD has become one of the most prevalent liver diseases in adults worldwide, but its incidence in both children and adolescents has also markedly increased in developed nations3,4. Progression of this disease into nonalcoholic steatohepatitis (NASH), cirrhosis, liver failure, and hepatocellular carcinoma in combination with its widespread incidence thus makes NAFLD and its related pathologies a significant public health concern. Here, we review our understanding of the roles of dietary carbohydrates (glucose, fructose, and fibers) and the gut microbiota, which provides essential carbon sources for hepatic fat synthesis during the development of NAFLD.
Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity
Authors: Choi Won-Il , Yoon Jae-Hyun , Choi Seo-Hyun , Jeon Bu-Nam , Kim Hail , Hur Man-Wook
Published: May 2021

Zbtb7c is a proto-oncoprotein that controls the cell cycle and glucose, glutamate, and lipid metabolism. Zbtb7c expression is increased in the liver and white adipose tissues of aging or high-fat diet-fed mice. Knockout or knockdown of Zbtb7c gene expression inhibits the adipocyte differentiation of 3T3-L1 cells and decreases adipose tissue mass in aging mice. We found that Zbtb7c was a potent transcriptional repressor of SIRT1 and that SIRT1 was derepressed in various tissues of Zbtb7c-KO mice. Mechanistically, Zbtb7c interacted with p53 and bound to the proximal promoter p53RE1 and p53RE2 to repress the SIRT1 gene, in which p53RE2 was particularly critical. Zbtb7c induced p53 to interact with the corepressor mSin3A-HADC1 complex at p53RE. By repressing the SIRT1 gene, Zbtb7c increased the acetylation of Pgc-1α and Pparγ, which resulted in repression or activation of Pgc-1α or Pparγ target genes involved in lipid metabolism. Our study provides a molecular target that can overexpress SIRT1 protein in the liver, pancreas, and adipose tissues, which can be beneficial in the treatment of diabetes, obesity, longevity, etc.
Genome-wide association study of early-onset bipolar I disorder in the Han Taiwanese population
Authors: Wu Lawrence Shih-Hsin , Huang Ming-Chyi , Fann Cathy Shen-Jang , Lane Hsien-Yuan , Kuo Chian-Jue , Chiu Wei-Che , Kwok Pui-Yan , Cheng Andrew Tai-Ann
Published: May 2021

The search for susceptibility genes underlying the heterogeneous bipolar disorder has been inconclusive, often with irreproducible results. There is a hope that narrowing the phenotypes will increase the power of genetic analysis. Early-onset bipolar disorder is thought to be a genetically homogeneous subtype with greater symptom severity. We conducted a genome-wide association study (GWAS) for this subtype in bipolar I (BPI) disorder. Study participants included 1779 patients of Han Chinese descent with BPI disorder recruited by the Taiwan Bipolar Consortium. We conducted phenotype assessment using the Chinese version of the Schedules for Clinical Assessment in Neuropsychiatry and prepared a life chart with graphic depiction of lifetime clinical course for each of the BPI patient recruited. The assessment of onset age was based on this life chart with early onset defined as ≤20 years of age. We performed GWAS in a discovery group of 516 early-onset and 790 non-early-onset BPI patients, followed by a replication study in an independent group of 153 early-onset and 320 non-early-onset BPI patients and a meta-analysis with these two groups. The SNP rs11127876, located in the intron of CADM2, showed association with early-onset BPI in the discovery cohort (P = 7.04 × 10−8) and in the test of replication (P = 0.0354). After meta-analysis, this SNP was demonstrated to be a new genetic locus in CADM2 gene associated with early-onset BPI disorder (P = 5.19 × 10−8).
Characterization of gut microbiome in mice model of depression with divergent response to escitalopram treatment
Authors: Duan Jiajia , Huang Yu , Tan Xunmin , Chai Tingjia , Wu Jing , Zhang Hanping , Li Yifan , Hu Xi , Zheng Peng , Ji Ping , Zhao Libo , Yang Deyu , Fang Liang , Song Jinlin , Xie Peng
Published: May 2021

Depression is a common and heterogeneous mental disorder. Although several antidepressants are available to treat the patients with depression, the factors which could affect and predict the treatment response remain unclear. Here, we characterize the longitudinal changes of microbial composition and function during escitalopram treatment in chronic unpredictable mild stress (CUMS) mice model of depression based on 16 S rRNA sequencing and metabolomics. Consequently, we found that escitalopram (ESC) administration serves to increase the alpha-diversity of the gut microbiome in ESC treatment group. The microbial signatures between responder (R) and non-responder (NR) groups were significantly different. The R group was mainly characterized by increased relative abundances of genus Prevotellaceae_UCG-003, and depleted families Ruminococcaceae and Lactobacillaceae relative to NR group. Moreover, we identified 15 serum metabolites responsible for discriminating R and NR group. Those differential metabolites were mainly involved in phospholipid metabolism. Significantly, the bacterial OTUs belonging to family Lachnospiraceae, Helicobacteraceae, and Muribaculaceae formed strong co-occurring relationships with serum metabolites, indicating alternations of gut microbiome and metabolites as potential mediators in efficiency of ESC treatment. Together, our study demonstrated that the alterations of microbial compositions and metabolic functions might be relevant to the different response to ESC, which shed new light in uncovering the mechanisms of differences in efficacy of antidepressants.
Is the worst of the COVID-19 global pandemic yet to come? Application of financial mathematics as candidate predictive tools
Authors: Dogra Prashant , Koay Eugene J. , Wang Zhihui , Vahidy Farhaan S. , Ferrari Mauro , Pasqualini Renata , Arap Wadih , Boom Marc L. , Dirk Sostman H. , Cristini Vittorio
Published: May 2021

The Elliott Wave principle is a time-honored, oft-used method for predicting variations in the financial markets. It is based on the notion that human emotions drive financial decisions. In the fight against the COVID-19 global pandemic, human emotions are similarly decisive, for instance in that they determine one’s willingness to be vaccinated, and/or to follow preventive measures including the personal wearing of masks, the application of social distancing protocols, and frequent handwashing. On this basis, we postulated that the Elliott Wave Principle may similarly be used to predict the future evolution of the COVID-19 pandemic. We demonstrated that this method reproduces the data pattern for various countries and the world (daily new cases). Potential scenarios were then extrapolated, from the best-case corresponding to a rapid, full vaccination of the population, to the utterly disastrous case of slow vaccination, and poor adherence to preventive protocols.
Opposite alterations of 5­HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile
Authors: Diez-Alarcia Rebeca , Muguruza Carolina , Rivero Guadalupe , García-Bea Aintzane , Gómez-Vallejo Vanessa , Callado Luis F. , Llop Jordi , Martín Abraham , Meana J. Javier
Published: May 2021

The status of serotonin 5­HT2A receptors (5­HT2ARs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about 5­HT2AR density. Radiotracers bind different receptor conformations depending on their agonist, antagonist or inverse agonist properties. This study investigates 5­HT2AR density in the post-mortem prefrontal cortex from subjects with schizophrenia and controls using three radiotracers with a different pharmacological profile. The specific binding parameters of the inverse agonist [18F]altanserin, the agonist [3H]lysergic acid diethylamide (LSD) and the antagonist [3H]MDL100907 to brain cortex membranes from 20 subjects with schizophrenia and 20 individually matched controls were evaluated under similar methodological conditions. Ten schizophrenia subjects were antipsychotic-free at death. Saturation curve analyses were performed by non-linear regression to obtain a maximal density of binding sites (Bmax) and the affinity of the respective radiotracers (Kd). In schizophrenia subjects, 5-HT2AR density was decreased when quantified by [18F]altanserin binding, whereas increased when evaluated by [3H]LSD binding. However, [3H]MDL100907 binding was unaltered. A slight loss of affinity (higher Kd) was observed exclusively in [3H]LSD binding. The findings were more evident in antipsychotic-free subjects than in antipsychotic-treated subjects. In conclusion, a higher proportion of the 5-HT2AR-active functional conformation, which is rather identified by agonist radiotracers, was observed in schizophrenia patients. A consequent reduction of the inactive 5-HT2AR conformation, which is preferentially identified by inverse agonist radiotracers, was also obtained. Antagonist radiotracers do not distinguish between molecular conformations of the receptor, and accordingly, the absence of changes was shown. These results are compatible with the proposed increased functional activity of brain cortical 5-HT2ARs in schizophrenia.
A bioinformatic study revealed serotonergic neurons are involved in the etiology and therapygenetics of anxiety disorders
Authors: Liu Han-Kui , He Si-Jie , Zhang Jian-Guo
Published: May 2021

Genetic factors contribute to the susceptibility of anxiety disorders (ADs) and responses to associated cognitive-behavioral therapy (CBT). However, the type of brain cell affected by the related genes remains unclear. Previous studies have indicated various important brain neurons associated with psychiatric disorders, highlighting the necessity to study the cellular basis of anxiety. We assembled 37 AD-related genes and 23 CBT-related genes from recent large-scale genome-wide association studies, and then investigated their cell-type specificity in single-cell transcriptome data via an expression weighted cell type enrichment method. Additionally, to investigate the cellular differences between ADs and other psychiatric disorders, we excluded the genes associated with major depressive disorder, bipolar disorder, and neuroticism, resulting in 29 AD-specific genes. Remarkably, results indicate that serotonergic neurons are significantly associated with both AD-related and CBT-related genes, despite the two gene sets showing no overlap. These observations provide evidence that serotonergic neurons are involved in the etiology and therapygenetics of ADs. Moreover, results also showed that serotonergic neurons are associated with AD-specific genes, providing a supplementary finding that is in opposition to previous studies that found no evidence for the association between serotonergic neurons and psychiatric disorders via the same strategy. In summary, the current study found that serotonergic neurons are involved in the etiology and therapygenetics of ADs, providing insights into their genetic and cellular basis. Further, this cellular difference study may deepen our understanding of ADs and other psychiatric disorders.