bluuebunny/crossref_metadata_2025 huggingface dataset:
Facile Synthesis of High-Quality Nano-Size 10B-Enriched Fibers of Hexagonal Boron Nitride
Authors: Ahmad Pervaiz , Khandaker Mayeen Uddin , Rehman Fida , Muhammad Nawshad , Faruque Mohammad Rashed Iqbal , Ullah Zahoor , Khan Muhammad Abdul Rauf , Khan Ghulamullah , Khan Muhammad Imtiaz , Ali Hazrat , Haq Sirajul , Iqbal Yousaf , Alzimami Khalid , Jambi Layal , Bradley David A.
Published: February 2021

The interesting properties of hexagonal boron nitride (h-BN) and its potential uses in thermo-structural advanced applications have been limited or restricted by its inherent brittleness, which can easily be eliminated by its fibers (h-BN) in nanoscale dimensions. The current study is based on the synthesis of nanoscale 10B-enriched fibers of h-BN (10BNNFs) from 10B in the precursors instead of B in two-hour annealing at 900 °C and one-hour growth at 1000 °C. All of the 10BNNFs are randomly curved and highly condensed or filled from 10h-BN species with no internal space or crack. XRD peaks reported the 10h-BN phase and highly crystalline nature of the synthesized 10BNNFs. 10h-BN phase and crystalline nature of 10BNNFs are confirmed from high-intensity peaks at 1392 (cm−1) in Raman and FTIR spectroscopes.
A Photomicroscopic Study on the Growth Rates of Calcium Oxalate Crystals in a New Synthetic Urine without Inhibitors and with Various Inhibitors
Authors: Hsu Yu-Chao , Pan Li-Cheng , Shiau Lie-Ding
Published: February 2021

A photomicroscopic growth apparatus was used to study the growth rates of calcium oxalate crystals in a new synthetic urine without inhibitors and with various inhibitors, including magnesium ions, citrate ions, chondroitin sulfate ions, and phytate ions. The dependence of growth rates on supersaturation at different temperatures without inhibitors was investigated using a power law model in terms of the Arrhenius form. The effects of various inhibitors on the growth rates of calcium oxalate indicated that the inhibition of growth rates increases in the order magnesium ions < citrate ions < chondroitin sulfate ions < phytate ions. The polymorphic forms of calcium oxalate crystals without inhibitors and with various inhibitors were examined by scanning electron microscopy.
Nematode Community-Based Soil Food Web Analysis of Ferralsol, Lithosol and Nitosol Soil Groups in Ghana, Kenya and Malawi Reveals Distinct Soil Health Degradations
Authors: Melakeberhan Haddish , Maung ZinThuZar , Lartey Isaac , Yildiz Senol , Gronseth Jenni , Qi Jiaguo , Karuku George N. , Kimenju John W. , Kwoseh Charles , Adjei-Gyapong Thomas
Published: February 2021

Determining if the vast soil health degradations across the seven major soil groups (orders) of Sub-Saharan Africa (SSA) can be managed on the basis of a one-size-fits-all or location-specific approach is limited by a lack of soil group-based understanding of soil health degradations. We used the relationship between changes in nematode population dynamics relative to food and reproduction (enrichment, EI) and resistance to disturbance (structure, SI) indices to characterize the soil food web (SFW) and soil health conditions of Ferralsol, Lithosol and Nitosol soil groups in Ghana, Kenya and Malawi. We applied bivariate correlations of EI, SI, soil pH, soil organic carbon (SOC), and texture (sand, silt and clay) to identify integrated indicator parameters, and principal component analysis (PCA) to determine how all measured parameters, soil groups, and countries align. A total of 512 georeferenced soil samples from disturbed (agricultural) and undisturbed (natural vegetation) landscapes were analyzed. Nematode trophic group abundance was low and varied by soil group, landscape and country. The resource-limited and degraded SFW conditions separated by soil groups and by country. EI and SI correlation with SOC varied by landscape, soil group or country. PCA alignment showed separation of soil groups within and across countries. The study developed the first biophysicochemical proof-of-concept that the soil groups need to be treated separately when formulating scalable soil health management strategies in SSA.
Tear Osmolarity in the Diagnosis of Systemic Dehydration and Dry Eye Disease
Authors: Bron Anthony J. , Willshire Catherine
Published: February 2021

Systemic dehydration due to inadequate water intake or excessive water loss, is common in the elderly and results in a high morbidity and significant mortality. Diagnosis is often overlooked and there is a need for a simple, bedside diagnostic test in at-risk populations. Body hydration is highly regulated with plasma osmolality (pOsm) being tightly controlled over a wide range of physiological conditions. By contrast, normal tear osmolarity (tOsm) is more variable since the tear film is exposed to evaporation from the open eye. While plasma hyperosmolality is a diagnostic feature of systemic dehydration, tear hyperosmolality, with other clinical features, is diagnostic of dry eye. Studies in young adults subjected to exercise and water-deprivation, have shown that tOsm may provide an index of pOsm, with the inference that it may provide a simple measure to diagnose systemic dehydration. However, since the prevalence of both dry eye and systemic dehydration increases with age, the finding of a raised tOsm in the elderly could imply the presence of either condition. This diagnostic difficulty can be overcome by measuring tear osmolality after a period of evaporative suppression (e.g., a 45 min period of lid closure) which drives tOsm osmolality down to a basal level, close to that of the pOsm. The arguments supporting the use of this basal tear osmolarity (BTO) in the diagnosis of systemic dehydration are reviewed here. Further studies are needed to confirm that the BTO can act as a surrogate for pOsm in both normally hydrated subjects and in patients with systemic dehydration and to determine the minimum period of lid closure required for a simple, “point-of-care” test.
Investigating Pre-Service Biology Teachers’ Diagnostic Competences: Relationships between Professional Knowledge, Diagnostic Activities, and Diagnostic Accuracy
Authors: Kramer Maria , Förtsch Christian , Boone William J. , Seidel Tina , Neuhaus Birgit J.
Published: February 2021

Teachers’ diagnostic competences are essential with respect to student achievement, classroom assessment, and instructional quality. Important components of diagnostic competences are teachers’ professional knowledge including content knowledge (CK), pedagogical knowledge (PK), and pedagogical content knowledge (PCK), their diagnostic activities as a specification of situation-specific skills, and diagnostic accuracy. Accuracy is determined by comparing a teacher’s observation of classroom incidents with subject-specific challenges to be identified from scripted instructional situations. To approximate diagnostic situations close to real-life, the assessment of science teachers’ diagnostic competences requires a situated context that was provided through videotaped classroom situations in this study. We investigated the relationship between professional knowledge (PCK, CK, PK) of 186 pre-service biology teachers, their diagnostic activities, and diagnostic accuracy measured with the video-based assessment tool DiKoBi Assess. Results of path analyses utilizing Rasch measures showed that both PCK and PK were statistically significantly related to pre-service teachers’ diagnostic activities. Additionally, biology teachers’ PCK was positively related to diagnostic accuracy. Considering higher effect sizes of PCK compared to PK, the findings support previous findings indicating the importance of PCK, thus demonstrating its importance in the context of subject-specific diagnosis as well.
Frequency Tuning Characteristics of a High-Power Sub-THz Gyrotron with Quasi-Optical Cavity
Authors: Guan Xiaotong , Zhang Jiayi , Fu Wenjie , Lu Dun , Yang Tongbin , Yan Yang , Yuan Xuesong
Published: February 2021

Motivated by some emerging high-frequency applications, a high-power frequency-tunable sub-THz quasi-optical gyrotron cavity based on a confocal waveguide is designed in this paper. The frequency tuning characteristics of different approaches, including magnetic field tuning, mirror separation adjustment, and hybrid tuning, have been investigated by particle-in-cell (PIC) simulation. Results predict that it is possible to realize a smooth continuous frequency tuning band with an extraordinarily broad bandwidth of 41.55 GHz, corresponding to a relative bandwidth of 18.7% to the center frequency of 0.22 THz. The frequency tunability is provided by varying the separation distance between two mirrors and correspondingly adjusting the external magnetic field. During the frequency tuning, the output power remains higher than 20 kW, which corresponds to an interaction efficiency of 10%. Providing great advantages in terms of broad bandwidth, smooth tuning, and high power, this research may be conducive to the development of high-power frequency-tunable THz gyrotron oscillators.
Transformer-Based VCO for W-Band Automotive Radar Applications
Authors: Cavarra Andrea , Papotto Giuseppe , Parisi Alessandro , Finocchiaro Alessandro , Nocera Claudio , Palmisano Giuseppe
Published: February 2021

A transformer-based voltage-controlled oscillator for a W-band frequency-modulated continuous-wave (FMCW) automotive radar application is presented. The design challenges imposed by the millimeter-wave frequency operation were faced through a circuit and layout co-design approach, supported by extensive electromagnetic simulations and accurate analysis of both the start-up condition and the tank quality factor. The oscillator was implemented in a 28-nm fully depleted silicon-on-insulator (SOI) complementary metal–oxide–semiconductor (CMOS) technology. It provided a 37 GHz oscillation frequency with a variation of around 4 GHz, thus achieving a tuning range of 11%. Moreover, a 77 GHz output signal was also delivered, which was extracted as a second harmonic from the input-pair common-mode node. The circuit exhibited low phase noises, whose average performances were −97 dBc/Hz and −121 dBc/Hz at 1 MHz and 10 MHz offset frequencies, respectively. It delivered a 77-GHz output power of −10.5 dBm and dissipated 26 mW with a 1 V power supply. The silicon area occupation was 300 × 135 µm.
A Fading Tolerant Phase-Sensitive Optical Time Domain Reflectometry Based on Phasing-Locking Structure
Authors: Zhang Xuping , Zheng Yunyin , Zhang Chi , Dong Qiuhao , Zhao Shisong , Liu Jingxiao , Wang Feng , Zhang Yixin , Xiong Fei
Published: February 2021

The demand for phase-sensitive optical time domain reflectometry (φ-OTDR), which is capable of reconstructing external disturbance accurately, is increasing. However, φ-OTDR suffers from fading where Rayleigh backscattering traces (RBS) have low amplitude and may be lower than the noise floor. Therefore, signal-to-noise ratio (SNR) is reduced. In conventional coherent φ-OTDR, an acoustic optical modulator (AOM), which consists of an RF driving source and an acousto-optic crystal, is commonly used to generate optical pulses and frequency shifts. Since RF driving and external modulation signals come from an independent oscillation source, every intermediate frequency (IF) trace has a different phase bias. Therefore, it is difficult to average the IF signals directly for noise reduction. In this paper, a coherent φ-OTDR system based on phase-locking structure was proposed. This structure provided a clock homologous carrier signal, a modulation signal and a data acquisition (DAQ) trigger signal. Then, moving average methods were taken on IF signals before phase demodulating to reduce the overall noise floor of the system. This new φ-OTDR is more tolerant to fading, which can provide higher accuracy for vibration reconstruction. The frequency response range of vibration was as low as 1Hz, and a 25dB improvement of SNR was achieved.
Evolution-Strategies-Driven Optimization on Secure and Reconfigurable Interconnection PUF Networks
Authors: Gu Hongxiang , Potkonjak Miodrag
Published: February 2021

Physical Unclonable Functions (PUFs) are known for their unclonability and light-weight design. However, several known issues with state-of-the-art PUF designs exist including vulnerability against machine learning attacks, low output randomness, and low reliability. To address these problems, we present a reconfigurable interconnected PUF network (IPN) design that significantly strengthens the security and unclonability of strong PUFs. While the IPN structure itself significantly increases the system complexity and nonlinearity, the reconfiguration mechanism remaps the input–output mapping before an attacker could collect sufficient challenge-response pairs (CRPs). We also propose using an evolution strategies (ES) algorithm to efficiently search for a network configuration that is capable of producing random and stable responses. The experimental results show that applying state-of-the-art machine learning attacks result in less than 53.19% accuracy for single-bit output prediction on a reconfigurable IPN with random configurations. We also show that, when applying configurations explored by our proposed ES method instead of random configurations, the output randomness is significantly improved by 220.8% and output stability by at least 22.62% in different variations of IPN.
Variable Clock and EM Signal Generation Scheme for Foveation-Based Driving OLED Head-Mounted Displays
Authors: Bae Jina , Lee Junhee , Nam Hyoungsik
Published: February 2021

An image processing pipeline and multi-output shift register of a foveation-based driving scheme are proposed for the realization of immersive head-mounted displays in 2019. In addition, this paper describes a variable clock generation circuit to manipulate output waveforms of shift registers in the foveated display. The EM circuit for OLED displays is also introduced to support the control signal to keep OLEDs of pixels from emitting light during the compensation. Especially, the EM circuit consists of only four TFTs and one capacitor and gives rise to pulses of variable widths corresponding to the resolution of a driven display area. A variable clock generation scheme is verified with 60 Hz 1440 × 2560 monitor, eye-tracker, PSoC board and FPGA board. An EM circuit is simulated by SPICE for 9600 lines and 120 Hz foveated displays.
Dendrogeomorphology of Different Landslide Types: A Review
Authors: Šilhán Karel
Published: February 2021

The dating of past landslide events is one of the most crucial aspects of landslide research, leading to a better understanding of past landslide activity. Landslides can be extremely dangerous natural hazards, and thus, solving the relationships between their activity and climate variations is of high importance. For these purposes, data about past landslide activity are fundamental for such analyses. Various methods of landslide absolute dating exist, but the most precise approach that dates back several centuries is based on tree-ring analysis (dendrogeomorphology). Landslide movements can affect the growth of trees in response to specific growth disturbances. Although dendrogeomorphic methods are successfully used for dating other geomorphic processes, their use in landslide research is actually the most frequent. Dendrogeomorphic research on landslides is strongly influenced by general approaches of landslide signal extraction from tree-ring series of disturbed trees and by the type of landslide (varying by morphology, material and mechanism of movement). This study provides an overview of basic aspects of dendrogeomorphic research on landslides, and more specifically, it reviews basic tree-ring-based approaches of landslide dating. Presented review focuses on various landslide types and their effect on dendrogeomorphic dating. This review is built from the extensive database of all accessible dendrogeomorphic studies of landslides from 1893 to 2020. Moreover, recommendations for specific sampling and approach choice in individual landslide types are presented. Finally, limits of tree-ring-based approaches are presented, including provided proposals for further research.
Online Professional Learning in Response to COVID-19—Towards Robust Evaluation
Authors: Ahadi Alireza , Bower Matt , Singh Abhay , Garrett Michael
Published: February 2021

As COVID-19 continues to impact upon education worldwide, systems and organizations are rapidly transiting their professional learning to online mode. This raises concerns, not simply about whether online professional learning can result in equivalent outcomes to face-to-face learning, but more importantly about how to best evaluate online professional learning so we can iteratively improve our approaches. This case study analyses the evaluation of an online teacher professional development workshop for the purpose of critically reflecting upon the efficacy of workshop evaluation techniques. The evaluation approach was theoretically based in a synthesis of six seminal workshop evaluation models, and structured around eight critical dimensions of educational technology evaluation. The approach involving collection of pre-workshop participant background information, pre-/post-teacher perceptions data, and post-workshop focus group perceptions, enabled the changes in teacher knowledge, skills, and beliefs to be objectively evaluated, at the same time as providing qualitative information to effectively improve future iterations of the workshops along a broad range of dimensions. The evaluation approach demonstrated that the professional learning that was shifted into online mode in response to COVID-19 could unequivocally result in significant improvements to professional learning outcomes. More importantly, the evaluation approach is critically contrasted with previous evaluation models, and a series of recommendations for the evaluation of technology-enhanced teacher professional development workshops are proposed.
Influence of Durum Wheat Bran Particle Size on Phytochemical Content and on Leavened Bread Baking Quality
Authors: Alzuwaid Nabeel T. , Pleming Denise , Fellows Christopher M. , Laddomada Barbara , Sissons Mike
Published: February 2021

Wheat bran is a conventional by-product of the wheat milling industry mainly used for animal feed. It is a rich and inexpensive source of phytonutrients, so is in demand for fibre-rich food products but creates quality issues when incorporated into bread. The purpose of this study was to characterize the physicochemical properties and phytochemical composition of different size durum bran fractions and show how they impact bread quality. Durum wheat (Triticum durum Desf.) was milled to create a coarse bran fraction (CB), which was further ground into a finer fraction (FB) which was sieved using four screens with apertures 425, 315, 250, 180, and <180 µm to create a particle size range of 1497 to 115 µm. All fractions contained phytosterol with highest in the 180 and FB, while total phenolic acids and antioxidant capacity was highest in CB and 425. Use of the fractions in a leavened common wheat (T. aestivum L.) bread formula at 10% incorporation negatively impacted bread loaf volume, colour, and texture compared to standard loaves, with CB having the least impact. Results suggest that to combine the highest phytochemical content with minimal impact on bread quality, bran particle size should be considered, with CB being the best choice.
Post-Translational Mechanisms of Plant Circadian Regulation
Authors: Yan Jiapei , Kim Yeon Jeong , Somers David E.
Published: February 2021

The molecular components of the circadian system possess the interesting feature of acting together to create a self-sustaining oscillator, while at the same time acting individually, and in complexes, to confer phase-specific circadian control over a wide range of physiological and developmental outputs. This means that many circadian oscillator proteins are simultaneously also part of the circadian output pathway. Most studies have focused on transcriptional control of circadian rhythms, but work in plants and metazoans has shown the importance of post-transcriptional and post-translational processes within the circadian system. Here we highlight recent work describing post-translational mechanisms that impact both the function of the oscillator and the clock-controlled outputs.
Comparative Analysis, Characterization and Evolutionary Study of Dirigent Gene Family in Cucurbitaceae and Expression of Novel Dirigent Peptide against Powdery Mildew Stress
Authors: Yadav Vivek , Wang Zhongyuan , Yang Xiaozhen , Wei Chunhua , Changqing Xuan , Zhang Xian
Published: February 2021

Dirigent (DIR) proteins are induced under various stress conditions and involved in sterio- and regio-selective coupling of monolignol. A striking lack of information about dirigent genes in cucurbitaceae plants underscores the importance of functional characterization. In this study, 112 DIR genes were identified in six species, and 61 genes from major cultivated species were analyzed. DIRs were analyzed using various bioinformatics tools and complemented by expression profiling. Phylogenetic analysis segregated the putative DIRs into six distinctively known subgroups. Chromosomal mapping revealed uneven distribution of genes, whereas synteny analysis exhibited that duplication events occurred during gene evolution. Gene structure analysis suggested the gain of introns during gene diversification. Gene ontology (GO) enrichment analysis indicates the participation of proteins in lignification and pathogen resistance activities. We also determined their organ-specific expression levels in three species revealing preferential expression in root and leaves. Furthermore, the number of CmDIR (CmDIR1, 6, 7 and 12) and ClDIR (ClDIR2, 5, 8, 9 and 17) genes exhibited higher expression in resistant cultivars after powdery mildew (PM) inoculation. In summary, based on the expression and in-silico analysis, we propose a role of DIRs in disease resistance mechanisms.
Self-Reported Waiting Times for Outpatient Health Care Services in Hungary: Results of a Cross-Sectional Survey on a National Representative Sample
Authors: Brito Fernandes Óscar , Lucevic Armin , Péntek Márta , Kringos Dionne , Klazinga Niek , Gulácsi László , Zrubka Zsombor , Baji Petra
Published: February 2021

(1) Background: System-level data on waiting time in the outpatient setting in Hungary is scarce. The objective of the study was to explore self-reported waiting time for an appointment and at a doctor’s office. (2) Methods: An online, cross-sectional, self-administered survey was carried out in 2019 in Hungary among a representative sample (n = 1000) of the general adult population. Chi-squared test and logistic regression analysis were carried out to explore if socioeconomic characteristics, health status, or residence were associated with waiting times and the perception of waiting time as a problem. (3) Results: Proportions of 90%, 41%, and 64% of respondents were seen within a week by family doctor, public specialist, and private specialist, respectively. One-third of respondents waited more than a month to get an appointment with a public specialist. Respondents in better health status reported shorter waiting times; those respondents were less likely to perceive a problem with: (1) waiting time to get an appointment (OR = 0.400) and (2) waiting time at a doctor’s office (OR = 0.519). (4) Conclusions: Longest waiting times were reported for public specialist visits, but waiting times were favorable for family doctors and private specialists. Further investigation is needed to better understand potential inequities affecting people in worse health status.
Nature’s Role in Supporting Health during the COVID-19 Pandemic: A Geospatial and Socioecological Study
Authors: Robinson Jake M. , Brindley Paul , Cameron Ross , MacCarthy Danielle , Jorgensen Anna
Published: February 2021

The COVID-19 pandemic has brought about unprecedented changes to human lifestyles across the world. The virus and associated social restriction measures have been linked to an increase in mental health conditions. A considerable body of evidence shows that spending time in and engaging with nature can improve human health and wellbeing. Our study explores nature’s role in supporting health during the COVID-19 pandemic. We created web-based questionnaires with validated health instruments and conducted spatial analyses in a geographic information system (GIS). We collected data (n = 1184) on people’s patterns of nature exposure, associated health and wellbeing responses, and potential socioecological drivers such as relative deprivation, access to greenspaces, and land-cover greenness. The majority of responses came from England, UK (n = 993). We applied a range of statistical analyses including bootstrap-resampled correlations and binomial regression models, adjusting for several potential confounding factors. We found that respondents significantly changed their patterns of visiting nature as a result of the COVID-19 pandemic. People spent more time in nature and visited nature more often during the pandemic. People generally visited nature for a health and wellbeing benefit and felt that nature helped them cope during the pandemic. Greater land-cover greenness within a 250 m radius around a respondent’s postcode was important in predicting higher levels of mental wellbeing. There were significantly more food-growing allotments within 100 and 250 m around respondents with high mental wellbeing scores. The need for a mutually-advantageous relationship between humans and the wider biotic community has never been more important. We must conserve, restore and design nature-centric environments to maintain resilient societies and promote planetary health.
Do Observed Teaching Behaviors Relate to Students’ Engagement in Physical Education?
Authors: González-Peño Alba , Franco Evelia , Coterón Javier
Published: February 2021

Teachers’ behaviors can affect students’ engagement in the Physical Education (PE) setting. According to self-determination theory, teachers can rely on either a need-supportive or a controlling teaching behavior, and these behaviors will differently affect students’ outcomes. The main objective of this research was to analyse how teaching behaviors and some contextual variables influence students’ engagement in PE classes. The present study adds to the existing literature through an observation-based design in which real-life examples of need-supportive and thwarting teaching behaviors, as well as students’ engagement behaviors, have been identified. Thirty-seven different PE lessons were coded for 5-min intervals to assess the occurrence of 36 teaching behaviors and five students’ behaviors. Stepwise regression revealed that both structure during activity and relatedness support could predict student engagement in a positive way. Surprisingly, cold teaching also emerged as a direct predictor in the last step of the analysis. On the other hand, controlling and structure before activity behaviors inversely predicted students’ engagement. These four variables explained 39% of the variance in student engagement, whereas autonomy support did not correlate with student engagement. These new findings in the field not only confirm the known relevance of teaching behavior for students’ outcomes but also suggest an unexpected lack of influence of autonomy support on students’ engagement as well as an association between cold teaching and students’ engagement. Results are discussed in the light of new approaches, and some practical implications are provided.
Housing Quality in a Rural and an Urban Settlement in South Africa
Authors: Mathee Angela , Moyes Jocelyn , Mkhencele Thulisa , Kleynhans Jackie , Language Brigitte , Piketh Stuart , Moroe Elias , Wafawanaka Floidy , Martinson Neil , McMorrow Meredith , Tempia Stefano , Kahn Kathleen , Cohen Cheryl
Published: February 2021

During 2016 to 2018, a prospective household cohort study of influenza and respiratory syncytial virus community burden and transmission dynamics (the PHIRST study) was undertaken to examine the factors associated with influenza and other respiratory pathogen transmissions in South Africa. We collected information on housing conditions in the PHIRST study sites: Rural villages near Agincourt, Bushbuckridge Municipality, Mpumalanga Province, and urban Jouberton Township in North West Province. Survey data were collected from 159 and 167 study households in Agincourt and Jouberton, respectively. Multiple housing-related health hazards were identified in both sites, but particularly in Agincourt. In Agincourt, 75% (119/159) of households reported daily or weekly interruptions in water supply and 98% (154/159) stored drinking water in miscellaneous containers, compared to 1% (1/167) and 69% (115/167) of households in Jouberton. Fuels other than electricity (such as wood) were mainly used for cooking by 44% (70/159) and 7% (11/167) of Agincourt and Jouberton households, respectively; and 67% (106/159) of homes in Agincourt versus 47% (79/167) in Jouberton were located on unpaved roads, which is associated with the generation of dust and particulate matter. This study has highlighted housing conditions in Agincourt and Jouberton that are detrimental to health, and which may impact disease severity or transmission in South African communities.
Oral Anticoagulant Adequacy in Non-Valvular Atrial Fibrillation in Primary Care: A Cross-Sectional Study Using Real-World Data (Fantas-TIC Study)
Authors: Dalmau Llorca M. Rosa , Aguilar Martín Carina , Carrasco-Querol Noèlia , Hernández Rojas Zojaina , Forcadell Drago Emma , Rodríguez Cumplido Dolores , Pepió Vilaubí Josep M. , Castro Blanco Elisabet , Gonçalves Alessandra Q. , Fernández-Sáez José
Published: February 2021

Background: Oral anticoagulants (OAs) are the treatment to prevent stroke in atrial fibrillation (AF). Anticoagulant treatment choice in non-valvular atrial fibrillation (NVAF) must be individualized, taking current guidelines into account. Adequacy of anticoagulant therapy under the current criteria for NVAF in real-world primary care is presented. Methods: Cross-sectional study, with real-world data from patients treated in primary care (PC). Data were obtained from the System for the Improvement of Research in Primary Care (SIDIAP) database, covering 60,978 NVAF-anticoagulated patients from 287 PC centers in 2018. Results: In total, 41,430 (68%) were treated with vitamin K antagonists (VKAs) and 19,548 (32%) NVAF with direct-acting oral anticoagulants (DOACs). Inadequate prescription was estimated to be 36.0% and 67.6%, respectively. Most DOAC inadequacy (77.3%) was due to it being prescribed as a first-line anticoagulant when there was no history of thromboembolic events or intracranial hemorrhage (ICH). A total of 22.1% had missing estimated glomerular filtration rate (eGFR) values. Common causes of inadequate VKA prescription were poor control of time in therapeutic range (TTR) (98.8%) and ICH (2.2%). Conclusions: Poor adequacy to current criteria was observed, being inadequacy higher in DOACs than in VKAs. TTR and GFR should be routinely calculated in electronic health records (EHR) to facilitate decision-making and patient safety.
Population Response to Air Pollution and the Risk of Coronavirus Disease in Chinese Cities during the Early Pandemic Period
Authors: Yoon Miryoung , Kim Jong-Hun , Sung Jisun , Lim Ah-Young , Hwang Myung-Jae , Kim Eun-Hye , Cheong Hae-Kwan
Published: February 2021

Health behavior is a critical measure in controlling the coronavirus disease 2019 (COVID-19) pandemic. We estimated the effect of health behaviors against air pollution on reducing the risk of COVID-19 during the initial phase of the pandemic. The attack rates of COVID-19 in 159 mainland Chinese cities during the first 2 weeks after the closure of major cities was estimated; air pollution level as a surrogate indicator of the mask-wearing rate. Data on air pollution levels and meteorologic factors 2 weeks prior to the closure were obtained. The attack rate was compared with the level of air pollution using a generalized linear model after adjusting for confounders. When fine particulates (PM2.5) and nitrogen dioxide (NO2) levels increased by one unit of air quality index (AQI), the infection risk decreased by 0.7% and 3.4%, respectively. When PM2.5 levels exceeded 150 (level 4), the infection risk decreased (relative risk, RR = 0.635, 95% confidence interval, CI: 0.442 to 0.912 for level 4; RR = 0.529, 95% CI: 0.337 to 0.830 for level 5; respectively). After controlling for the number of high-speed railway routes, when PM2.5 and NO2 levels increased by one AQI, relative risk for PM2.5 and NO2 was 0.990 (95% CI, 0.984 to 0.997) and 0.946 (95% CI, 0.911 to 0.982), respectively, demonstrating a consistently negative association. It is postulated that, during the early phase of the pandemic, the cities with higher air pollution levels may represent the higher practice of mask-wearing to protect from air pollution, which could have acted as a barrier to the transmission of the virus. This study highlights the importance of health behaviors, including mask-wearing for preventing infections.
Educating on Sexuality to Promote Health: Applied Experiences Mainstreaming the Gender and Human Rights Approach
Authors: Martínez-Abarca Ana L. , Martínez-Pérez Ana M.
Published: February 2021

In the articulation between research and health intervention, we see the need to situate comprehensive sexuality education in the triangle formed by the salutogenic approach, the mainstreaming of gender and human rights, and the development of competencies in health promotion. For this purpose, we present a set of investigations carried out in Ecuador and Spain through a qualitative methodology with the respective health interventions that seek to obtain significant results of the teaching–learning process on sexuality. The field work contemplates situations of violence as a health problem, orienting the intervention in health empowerment toward pleasure. The health education experiences implemented allow us to conclude that comprehensive sexuality education reinforces the competencies of health personnel to attend to diversity. These findings, and the results expected in ongoing research, allow us to form a competency framework aimed at specifically improving medical education so that medical professionals can generate health processes with a cross-cutting approach to gender and human rights.
Youths’ Habitual Use of Smartphones Alters Sleep Quality and Memory: Insights from a National Sample of Chinese Students
Authors: Li Xiaojing , Fu Siqi , Fu Qiang , Zhong Bu
Published: February 2021

A growing body of work has been devoted to studying the smartphone addiction in youths and its impact on their lives, but less is known about the predictors and effects of youth habitual use of smartphones. Guided by social cognitive theory, this study investigates how habitual smartphone use affects sleep quality and everyday memory based on a nationally representative sample of Chinese students (N = 2298). It uses a cluster-randomized sampling with stratification of different areas, consisting of both urban and rural students aged 6–18 years from elementary, middle, and high schools across China. It found that Chinese students exhibited a habitual smartphone use, who were generally confident in using mobile devices, but few had smartphone addiction. Significant gender and age differences were identified concerning the habitual use of smartphone. Specifically, boys demonstrated higher levels of habitual use and smartphone self-efficacy than the girls. High school students showed the highest level of habitual smartphone use compared to those in elementary and middle schools. Smartphone use duration, frequency, and self-efficacy predicted the habitual use, which also led to poorer sleep quality and worse memory outcomes. Prebedtime exposure moderated the relationship between habitual smartphone uses and sleep quality. The results show that students’ habitual smartphone use had a significant impact on their health, cognition and more, even when they exhibited little smartphone addiction. The findings contribute to a better understanding of smartphone impact on school-age youths.
Trypsin-Like Activity in Oral Cavity Is Associated with Risk of Fever Onset in Older Residents of Nursing Homes: An 8-Month Longitudinal Prospective Cohort Pilot Study
Authors: Izumi Maya , Isobe Ayaka , Akifusa Sumio
Published: February 2021

This study aimed to evaluate the association between trypsin-like activity in the oral cavity and the onset of fever in independent older residents of nursing homes. Independent older residents aged ≥ 65 years in 10 nursing homes were included in this study, which was conducted in Kitakyushu, Japan. For 8 months, follow-up dates on which the body temperatures of participants were more than 37.2 °C were noted. Trypsin-like activity in the oral cavity was detected by ADCHECK® with five-grade evaluation at baseline. Data from 53 independent participants with median age 89.0 (67–102) years were available for analysis. ADCHECK® scores were associated with fever days (r = 0.312, p = 0.029). The average periods until the onset of fever in participants with ADCHECK® Scores 1 and 2, Score 3, and Scores 4 and 5 were 6.6 ± 0.5, 5.0 ± 0.7, and 4.1 ± 1.0 months, respectively. ADCHECK® Scores 4 and 5 signified a higher risk of fever compared to ADCHECK® Scores 1 and 2 (hazards ratio 5.9, 95% confidence interval 1.4–23.9, p = 0.013), adjusted for possible confounders. We concluded that trypsin-like activity in the oral cavity was associated with the risk of fever in independent older residents of nursing homes.
A Review of the Impacts and Opportunities for African Urban Dragonflies
Authors: Deacon Charl , Samways Michael J.
Published: February 2021

Urban settlements range from small villages in rural areas to large metropoles with densely packed infrastructures. Urbanization presents many challenges to the maintenance of freshwater quality and conservation of freshwater biota, especially in Africa. There are many opportunities as well, particularly by fostering contributions from citizen scientists. We review the relationships between dragonflies and urbanization in southern Africa. Shifts in dragonfly assemblages indicate environmental change, as different species are variously sensitive to abiotic and biotic water and bank conditions. They are also conservation umbrellas for many other co-occurring species. Major threats to southern African dragonflies include increasing infrastructure densification, frequent droughts, habitat loss, pollution, and invasive alien vegetation. Mitigation measures include implementation of conservation corridors, maintenance of healthy permanent ponds, pollution reduction, and removal of invasive alien trees. Citizen science is now an important approach for supplementing and supporting professional scientific research.
Sterile Insect Technique (SIT) against Aedes Species Mosquitoes: A Roadmap and Good Practice Framework for Designing, Implementing and Evaluating Pilot Field Trials
Authors: Oliva Clélia F. , Benedict Mark Q. , Collins C Matilda , Baldet Thierry , Bellini Romeo , Bossin Hervé , Bouyer Jérémy , Corbel Vincent , Facchinelli Luca , Fouque Florence , Geier Martin , Michaelakis Antonios , Roiz David , Simard Frédéric , Tur Carlos , Gouagna Louis-Clément
Published: February 2021

Aedes albopictus and Aedes aegypti are invasive mosquito species that impose a substantial risk to human health. To control the abundance and spread of these arboviral pathogen vectors, the sterile insect technique (SIT) is emerging as a powerful complement to most commonly-used approaches, in part, because this technique is ecologically benign, specific, and non-persistent in the environment if releases are stopped. Because SIT and other similar vector control strategies are becoming of increasing interest to many countries, we offer here a pragmatic and accessible ‘roadmap’ for the pre-pilot and pilot phases to guide any interested party. This will support stakeholders, non-specialist scientists, implementers, and decision-makers. Applying these concepts will ensure, given adequate resources, a sound basis for local field trialing and for developing experience with the technique in readiness for potential operational deployment. This synthesis is based on the available literature, in addition to the experience and current knowledge of the expert contributing authors in this field. We describe a typical path to successful pilot testing, with the four concurrent development streams of Laboratory, Field, Stakeholder Relations, and the Business and Compliance Case. We provide a graphic framework with criteria that must be met in order to proceed.
Speckle Tracking Analysis Reveals Altered Left Atrial and Ventricular Myocardial Deformation in Patients with End-Stage Liver Disease
Authors: von Köckritz Franzisca , Braun Alexander , Schmuck Rosa B. , Dobrindt Eva M. , Eurich Dennis , Heinzel Frank R. , Pieske Burkert , Escher Felicitas , Zhang Kun
Published: February 2021

Background: Cardiac function can be influenced by liver cirrhosis and should be thoroughly evaluated before liver transplantation. We investigated left ventricular (LV) and, for the first time, left atrial (LA) strain and strain rate in end-stage liver cirrhosis patients of different etiologies. Methods: This retrospective, cross-sectional study evaluated left heart function in 80 cirrhosis patients and 30 controls using standardized echocardiographic techniques and speckle tracking technology (STE) analysis. Serum markers of liver function were used for correlation analysis. Results: While conventional parameters demonstrated no alteration in systolic function, speckle tracking analysis showed a significant increase in LV longitudinal strain throughout all cardiac layers, with significant correlation to model of end-stage liver disease (MELD) score. LA reservoir and conduit strain as well as LA strain rate in all phases were significantly reduced in end-stage liver disease (ESLD) patients compared to control. STE for the evaluation of LA phasic function seemed to be more sensitive than volumetric methods. Kaplan-Meier curves showed a trend towards reduced post-transplant survival in patients with a reduced LA reservoir and conduit strain. Conclusion: STE analysis detected increased LV and decreased LA deformation in cirrhosis patients, thus proving to be highly sensitive to cardiac changes and useful for more precise cardiac evaluation.
Host–Pathogen Interactions: Insects vs. Fungi
Authors: Dubovskiy Ivan M.
Published: February 2021

Although many insects successfully live in dangerous environments exposed to diverse communities of microbes, they are often exploited and killed by specialist pathogens [...]
Numerical Simulation and Experimental Validation of Surface Roughness by the Smoothing Small Ball-Burnishing Process
Authors: Banh Quoc-Nguyen , Nguyen Hai-Dang , Tran Anh Son
Published: February 2021

The smoothing ball-burnishing process has commonly been used as a post-processing method to reduce the irregularities of machined surfaces. However, the mechanism of this process has rarely been examined. In this study, a simulation procedure is proposed to predict the surface roughness of a burnished workpiece under varying burnishing forces. The roughness of the workpiece surface was firstly approximated by parabolic functions. The burnishing process was then numerically simulated through two steps, namely the elastic–plastic indentation of the burnishing ball on the workpiece’s surface, and the sliding movement of the burnishing tool. The results of the simulation were verified by conducting small ball-burnishing experiments on oxygen-free copper (OFC) and Polmax materials using a load cell-embedded small ball-burnishing tool. For the OFC material, the optimal burnishing force was 3 N. The obtained experimental surface roughness was 0.18 μm, and the simulated roughness value was 0.14 μm. For the Polmax material, when the burnishing force was set at its optimal value—12 N, the best experimental and simulated surface roughness were 0.12 μm and 0.10 μm, respectively.
Advances in Nanocomposite Membranes
Authors: Goh Pei Sean , Ismail Ahmad Fauzi
Published: February 2021

The design and synthesis of functional nanomaterials have been extensively explored over the last decade, primarily due to their exceptional physico-chemical properties [...]
Adjustment of the Mechanical Properties of Mg2Nd and Mg2Yb by Optimizing Their Microstructures
Authors: Schmidt Jonas , Beyerlein Irene J. , Knezevic Marko , Reimers Walter
Published: February 2021

The deformation behavior of the extruded magnesium alloys Mg2Nd and Mg2Yb was investigated at room temperature. By using in situ energy-dispersive synchrotron X-ray diffraction compression and tensile tests, accompanied by Elasto-Plastic Self-Consistent (EPSC) modeling, the differences in the active deformation systems were analyzed. Both alloying elements change and weaken the extrusion texture and form precipitates during extrusion and subsequent heat treatments relative to common Mg alloys. By varying the extrusion parameters and subsequent heat treatment, the strengths and ductility can be adjusted over a wide range while still maintaining a strength differential effect (SDE) of close to zero. Remarkably, the compressive and tensile yield strengths are similar and there is no mechanical anisotropy when comparing tensile and compressive deformation, which is desirable for industrial applications. Uncommon for Mg alloys, Mg2Nd shows a low tensile twinning activity during compression tests. We show that heat treatments promote the nucleation and growth of precipitates and increase the yield strengths isotopically up to 200 MPa. The anisotropy of the yield strength is reduced to a minimum and elongations to failure of about 0.2 are still achieved. At lower strengths, elongations to failure of up to 0.41 are reached. In the Mg2Yb alloy, adjusting the extrusion parameters enhances the rare-earth texture and reduces the grain size. Excessive deformation twinning is, however, observed, but despite this the SDE is still minimized.
Potassium Improves Drought Stress Tolerance in Plants by Affecting Root Morphology, Root Exudates, and Microbial Diversity
Authors: Xu Qiwen , Fu Hao , Zhu Bo , Hussain Hafiz Athar , Zhang Kangping , Tian Xiaoqing , Duan Meichun , Xie Xiaoyu , Wang Longchang
Published: February 2021

Potassium (K) reduces the deleterious effects of drought stress on plants. However, this mitigation has been studied mainly in the aboveground plant pathways, while the effect of K on root-soil interactions in the underground part is still underexplored. Here, we conducted the experiments to investigate how K enhances plant resistance and tolerance to drought by controlling rhizosphere processes. Three culture methods (sand, water, and soil) evaluated two rapeseed cultivars’ root morphology, root exudates, soil nutrients, and microbial community structure under different K supply levels and water conditions to construct a defensive network of the underground part. We found that K supply increased the root length and density and the organic acids secretion. The organic acids were significantly associated with the available potassium decomposition, in order of formic acid > malonic acid > lactic acid > oxalic acid > citric acid. However, the mitigation had the hormesis effect, as the appropriate range of K facilitated the morphological characteristic and physiological function of the root system with increases of supply levels, while the excessive input of K could hinder the plant growth. The positive effect of K-fertilizer on soil pH, available phosphorus and available potassium content, and microbial diversity index was more significant under the water stress. The rhizosphere nutrients and pH further promoted the microbial community development by the structural equation modeling, while the non-rhizosphere nutrients had an indirect negative effect on microbes. In short, K application could alleviate drought stress on the growth and development of plants by regulating the morphology and secretion of roots and soil ecosystems.