bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient Perspective of Cognitive Symptoms in Major Depressive Disorder: Retrospective Database and Prospective Survey Analyses (Preprint)
Authors: Chiauzzi Emil , Drahos Jennifer , Sarkey Sara , Curran Christopher , Wang Victor , Tomori Dapo
Published: July 2018

BACKGROUND

Major depressive disorder (MDD) is a common and burdensome condition. The clinical understanding of MDD is shaped by current research, which lacks insight into the patient perspective.

OBJECTIVE

This two-part study aimed to generate data from PatientsLikeMe, an online patient network, on the perception of cognitive symptoms and their prioritization in MDD.

METHODS

A retrospective data analysis (study 1) was used to analyze data from the PatientsLikeMe community with self-reported MDD. Information on patient demographics, comorbidities, self-rated severity of MDD, treatment effectiveness, and specific symptoms of MDD was analyzed. A prospective electronic survey (study 2) was emailed to longstanding and recently active members of the PatientsLikeMe MDD community. Study 1 analysis informed the objectives of the study 2 survey, which were to determine symptom perception and prioritization, cognitive symptoms of MDD, residual symptoms, and medication effectiveness.

RESULTS

In study 1 (N=17,166), cognitive symptoms were frequently reported, including “severe” difficulty in concentrating (28%). Difficulty in concentrating was reported even among patients with no/mild depression (80%) and those who considered their treatment successful (17%). In study 2 (N=2525), 23% (118/508) of patients cited cognitive symptoms as a treatment priority. Cognitive symptoms correlated with depression severity, including difficulty in making decisions, concentrating, and thinking clearly (rs=0.32, 0.36, and 0.34, respectively). Cognitive symptoms interfered with meaningful relationships and daily life tasks and had a profound impact on patients’ ability to work and recover from depression.

CONCLUSIONS

Patients acknowledge that cognitive dysfunction in MDD limits their ability to recover fully and return to a normal level of social and occupational functioning. Further clinical understanding and characterization of MDD for symptom prioritization and relapse risk due to residual cognitive impairment are required to help patients return to normal cognitive function and aid their overall recovery.
The Mediating Role of Visual Stimuli From Media Use at Bedtime on Psychological Distress and Fatigue in College Students: Cross-Sectional Study (Preprint)
Authors: Guan Yuan , Duan Wenjie
Published: July 2018

BACKGROUND

Empirical research has linked psychological distress with fatigue. However, few studies have analyzed the factors (eg, stimuli from bedtime media use) that affect the relationship between psychological distress and fatigue.

OBJECTIVE

The aim of this study was to examine whether visual stimuli from bedtime media use mediate the relationship between psychological distress and fatigue among college students.

METHODS

The sample included 394 participants (92 males, 302 females) with a mean age of 19.98 years (SD 1.43 years), all of whom were Chinese college students at an occupational university in Sichuan Province, China. Data were collected using a paper-based questionnaire that addressed psychological distress, stimuli from bedtime media use, and fatigue. Mediation analysis was conducted using the PROCESS macro version 2.16.2 for SPSS 22, which provided the 95% CIs.

RESULTS

Both psychological distress (r=.43, P<.001) and visual stimuli from bedtime media use (r=.16, P<.001) were positively related to fatigue. The association between auditory stimuli from bedtime media use and fatigue was not significant (r=.09, P=.08). The relationship between psychological distress and fatigue was partially mediated by visual stimuli from bedtime media use (beta=.01, SE 0.01, 95% CI 0.0023-0.0253).

CONCLUSIONS

The findings imply that psychological distress has an indirect effect on fatigue via visual stimuli from bedtime media use. In contrast, auditory stimuli from bedtime media use did not have the same effect. We suggest that college students should reduce bedtime media use, and this could be achieved as part of an overall strategy to improve health. Mobile health apps could be an option to improving young students’ health in daily life.
Therapeutic Duplication in Taiwan Hospitals for Patients With High Blood Pressure, Sugar, and Lipids: Evaluation With a Mobile Health Mapping Tool (Preprint)
Authors: Kan Wei-Chih , Kuo Shu-Chun , Chien Tsair-Wei , Lin Jui-Chung John , Yeh Yu-Tsen , Chou Willy , Chou Po-Hsin
Published: July 2018

BACKGROUND

Cardiovascular disease causes approximately half of all deaths in patients with type 2 diabetes. Duplicative prescriptions of medication in patients with high blood pressure (hypertension), high blood sugar (hyperglycemia), and high blood lipids (hyperlipidemia) have attracted substantial attention regarding the abuse of health care resources and to implement preventive measures for such abuse. Duplicative prescriptions may occur by patients receiving redundant medications for the same condition from two or more sources such as doctors, hospitals, and multiple providers, or as a result of the patient’s wandering among hospitals.

OBJECTIVE

We evaluated the degree of duplicative prescriptions in Taiwanese hospitals for outpatients with three types of medications (antihypertension, antihyperglycemia, and antihyperlipidemia), and then used an online dashboard based on mobile health (mHealth) on a map to determine whether the situation has improved in the recent 25 fiscal quarters.

METHODS

Data on duplicate prescription rates of drugs for the three conditions were downloaded from the website of Taiwan’s National Health Insurance Administration (TNHIA) from the third quarter of 2010 to the third quarter of 2016. Complete data on antihypertension, antihyperglycemia, and antihyperlipidemia prescriptions were obtained from 408, 414, and 359 hospitals, respectively. We used scale quality indicators to assess the attributes of the study data, created a dashboard that can be traced using mHealth, and selected the hospital type with the best performance regarding improvement on duplicate prescriptions for the three types of drugs using the weighted scores on an online dashboard. Kendall coefficient of concordance (W) was used to evaluate whether the performance rankings were unanimous.

RESULTS

The data quality was found to be acceptable and showed good reliability and construct validity. The online dashboard using mHealth on Google Maps allowed for easy and clear interpretation of duplicative prescriptions regarding hospital performance using multidisciplinary functionalities, and showed significant improvement in the reduction of duplicative prescriptions among all types of hospitals. Medical centers and regional hospitals showed better performance with improvement in the three types of duplicative prescriptions compared with the district hospitals. Kendall W was 0.78, indicating that the performance rankings were not unanimous (Chi square2=4.67, P=.10).

CONCLUSIONS

This demonstration of a dashboard using mHealth on a map can inspire using the 42 other quality indicators of the TNHIA by hospitals in the future.
An Analytics Framework for Physician Adherence to Clinical Practice Guidelines: Knowledge-Based Approach (Preprint)
Authors: Lee Jaehoon , Hulse Nathan C
Published: July 2018

BACKGROUND

One of the problems in evaluating clinical practice guidelines (CPGs) is the occurrence of knowledge gaps. These gaps may occur when evaluation logics and definitions in analytics pipelines are translated differently.

OBJECTIVE

The objective of this paper is to develop a systematic method that will fill in the cognitive and computational gaps of CPG knowledge components in analytics pipelines.

METHODS

We used locally developed CPGs that resulted in care process models (CPMs). We derived adherence definitions from the CPMs, transformed them into computationally executable queries, and deployed them into an enterprise knowledge base that specializes in managing clinical knowledge content. We developed a visual analytics framework, whose data pipelines are connected to queries in the knowledge base, to automate the extraction of data from clinical databases and calculation of evaluation metrics.

RESULTS

In this pilot study, we implemented 21 CPMs within the proposed framework, which is connected to an enterprise data warehouse (EDW) as a data source. We built a Web–based dashboard for monitoring and evaluating adherence to the CPMs. The dashboard ran for 18 months during which CPM adherence definitions were updated a number of times.

CONCLUSIONS

The proposed framework was demonstrated to accommodate complicated knowledge management for CPM adherence evaluation in analytics pipelines using a knowledge base. At the same time, knowledge consistency and computational efficiency were maintained.
An Automated Text-Messaging Platform for Enhanced Retention and Data Collection in a Longitudinal Birth Cohort: Cohort Management Platform Analysis (Preprint)
Authors: Barry Caroline M , Sabhlok Aditi , Saba Victoria C , Majors Alesha D , Schechter Julia C , Levine Erica L , Streicher Martin , Bennett Gary G , Kollins Scott H , Fuemmeler Bernard F
Published: July 2018

BACKGROUND

Traditional methods for recruiting and maintaining contact with participants in cohort studies include print-based correspondence, which can be unidirectional, labor intensive, and slow. Leveraging technology can substantially enhance communication, maintain engagement of study participants in cohort studies, and facilitate data collection on a range of outcomes.

OBJECTIVE

This paper provides an overview of the development process and design of a cohort management platform (CMP) used in the Newborn Epigenetic STudy (NEST), a large longitudinal birth cohort study.

METHODS

The platform uses short message service (SMS) text messaging to facilitate interactive communication with participants; it also semiautomatically performs many recruitment and retention procedures typically completed by research assistants over the course of multiple study follow-up visits.

RESULTS

Since February 2016, 302 participants have consented to enrollment in the platform and 162 have enrolled with active engagement in the system. Daily reminders are being used to help improve adherence to the study’s accelerometer wear protocol. At the time of this report, 213 participants in our follow-up study who were also registered to use the CMP were eligible for the accelerometer protocol. Preliminary data show that texters (138/213, 64.8%), when compared to nontexters (75/213, 35.2%), had significantly longer average accelerometer-wearing hours (165.6 hours, SD 56.5, vs 145.3 hours, SD 58.5, P=.01) when instructed to wear the devices for 1 full week.

CONCLUSIONS

This platform can serve as a model for enhancing communication and engagement with longitudinal study cohorts, especially those involved in studies assessing environmental exposures.
IgA Nephropathy Susceptibility Loci and Disease Progression
Authors: Shi Manman , Ouyang Yan , Yang Mingxin , Yang Meng , Zhang Xiaoyan , Huang Wei , Wang Weiming , Wang Zhaohui , Zhang Wen , Chen Xiaonong , Pan Xiaoxia , Ren Hong , Chen Nan , Xie Jingyuan
Published: July 2018

Background and objectives

At least 20 susceptibility loci of IgA nephropathy have been identified by genome-wide association studies to date. Whether these loci were associated with disease progression is unclear.

Design, setting, participants, & measurements

We enrolled 613 adult patients with IgA nephropathy for a follow-up of ≥12 months. All 20 IgA nephropathy susceptibility loci were selected and their tag single nucleotide polymorphisms (SNPs) were genotyped. After strict quality control, 16 SNPs and 517 patients with IgA nephropathy were eligible for subsequent analysis. Progression was defined as ESKD or 50% decrease in eGFR. A stepwise Cox regression analysis of all SNPs on Akaike information criterion was performed to select the best model.

Results

A four-SNP model, rs11150612 (ITGAM-ITGAX), rs7634389 (ST6GAL1), rs2412971 (HORMAD2), and rs2856717 (HLA-DQ/DR), was selected as the best predictive model. The genetic risk score calculated on the basis of the four SNPs was independently associated with disease progression before (hazard ratio [HR], 1.65; 95% confidence interval [95% CI], 1.29 to 2.12) and after adjustment by a recently reported clinical model (HR, 1.29; 95% CI, 1.03 to 1.62) or clinical–pathologic model (HR, 1.35; 95% CI, 1.03 to 1.77). Compared with low genetic risk, patients with middle genetic risk had a 2.12-fold (95% CI, 1.33 to 3.40) increase of progression risk, whereas patients with high genetic risk had 3.61-fold (95% CI, 2.00 to 6.52) progression risk increase. In addition, incorporation of genetic risk score could potentially increase discrimination of the clinical model (c-statistic increase from 0.83 to 0.86) or the clinical–pathologic model (c-statistic increase from 0.82 to 0.85) in predicting 5-year progression risk.

Conclusions

The four-SNP genetic risk score was independently associated with IgA nephropathy progression and could enhance the performance of clinical and clinical–pathologic risk models.
A Review of Free Optical Satellite Imagery for Watershed-Scale Landscape Analysis
Authors: Bevington Alexandre , Gleason Hunter , Giroux-Bougard Xavier , De Jong J. Tyler
Published: July 2018

Watershed-scale landscape analysis includes many disciplines, including ecological, hydrological, and geographical sciences. The recent proliferation of free optical satellite imagery (FOSI) has changed the possibilities for the monitoring of environmental change at local and global scales. Many reviews exist for discipline-specific remote sensing applications; however, this article seeks to highlight the rapidly growing archive of FOSI and applied tools that can be used by all levels of users. Herein, ten techniques and eight applications of FOSI are reviewed, along with the specifications and limitations of various sources of FOSI. Although this review focuses on Western Canada, the democratization of FOSI is globally relevant, and the objective is to explain basic concepts via figures and reference materials to help summarize this rapidly changing field.
A REVIEW ON DRUG APPROVAL PROCESS FOR US, EUROPE AND INDIA
Authors: Prajapati Vishal , Goswami Rahulgiri , Makvana Pratik , Badjatya Jitendra Kumar
Published: July 2018

Developing a new drug requires great amount of research work in chemistry, manufacturing, controls, preclinical science and clinical trials. Drug reviewers in regulatory agencies around the world bear the responsibility of evaluating whether the research data support the safety, effectiveness and quality control of a new drug product to serve the public health. Every country has its own regulatory authority, which is responsible to enforce the rules and regulations and issue the guidelines to regulate the marketing of the drugs. This article focuses on drug approval process in different countries like USA, Europe and India.
REGULATORY STRATEGY FOR REGISTRATION OF COMBINATION PRODUCTS TO US-FDA
Authors: Kotha Vihar , Elphine Prabahar , Rao Nadendla Rama , Bhrama Srinivasarao Desu
Published: July 2018

In pharmaceutical industry all the healthcare products are categorized into Drugs, Devices, and biologics and they are regulated by their respective departments of the regulatory authorities. Due to more and more development of science and technology in the current scenario, had led to the invention of innovative novel products in healthcare system for better diagnosis and treatment of diseases, advancement of these novel technologies have led to a the blurring of historical lines of separation between the healthcare products, so these advances had led to the existence of combination products.

Combination products raise a variety of regulatory and review challenges compared with single-entity products. They have the potential to provide enhanced therapeutic advantages. It ranges in complexity from Drug-eluting stents to gene therapy systems and from chemotherapeutic Drugs combined with monoclonal antibodies to novel nanotechnology-based Drug delivery systems. They include innovative products for diagnostic and therapeutic treatments of cardiovascular, metabolic, and oncologic disorders, among other types of products.

In this article we describe the regulations for registration of combination products in US and their regulatory considerations for identification, jurisdiction and review, premarket activities, applicability of Good Manufacturing Practices (GMPs) and post marketed requirements, adverse event reporting, inspection and enforcement.
SUPAC OF IMMEDIATE-RELEASE, MODIFIED- RELEASE AND SEMI-SOLID: A REGULATORY NOTE
Authors: Ashara Kalpesh C. , Mendapara Vishal P. , Mori Nitin M. , Badjatya J. K.
Published: July 2018

In today scenario, as per market demand there is definitely carry out an increment or decrease in production, this is called SUPAC. Different guidelines are provided for those different types of SUPAC in by different regulatory authority for manufacturing of product. Here SUPAC guidelines for USFDA are elaborated for production in this review article.
IMPORTANCE OF DEFICIENCY RESPONSE IN PHARMACEUTICAL ENVIRONMENT FOR DRUG APPROVAL
Authors: Tripathy Swagat , Murthy P. N.
Published: July 2018

This illustrates examples of series deficiencies, that’s how really company faces problem due to deficiency. It’s to convey the message if drug product manufacturer can visualize earlier all aspect of risks and manifest proactively, then there is always least chance to have the said deficiency received. However, even then if company also gets deficiency, company could have equipped with earlier data. So, what they need to do is to focus properly for addressing agency’s query by utilizing proper scientific and technical writing skills. How lack of visualization creates problem, how review cycle prolonged and how by dint of this issue approval got delayed has been clearly discussed in this case study. The reason of so many rounds of questions and review cycles become longer and finally approval got delayed is from the beginning itself agency was not satisfied or convinced with the justification given by said Company.
PYRAZOLINE SYNTHESIS THROUGH A CHALCONE INTERMEDIATE
Authors: Hedaitullah Md , Walia Ramanpreet , Khalid Iqbal , Singh Balwan , Hussain Asif
Published: July 2018

Pyrazoline derivatives, being used as potential medicinal agents, possess many important pharmacological activities and therefore they are useful materials in drug research. A series of these derivatives HT- 1 to HT- 6 containing  5-4-(chlorophenyl)-1,3-diphenyl- 4,5-dihydro-1H-pyrazole derivatives were synthesized, structures were confirmed using melting point, IR, NMR and MS and evaluated for their antibacterial activity using disc diffusion method at concentration 2mg/ml. The reference used was Amikacin and mostly, all synthesized compounds exhibited a significant antibacterial activity against Staphylococcus aureus (MTCC No. 96) as Gram positive bacteria, Staphylococcus epidermidis(MTCC No. 435) as Gram positive and Escherichia coli (MTCC No. 739) as Gram negative bacteria. It was observed that HT-1 and HT-2 possess good antibacterial potential against S. aureus, HT- 5 against S.epidermidis and HT-1 and HT-4against E. coli.
LYOPHILIZATION - PROCESS AND OPTIMIZATION FOR PHARMACEUTICALS
Authors: Bisht Deepak , Iqbal Zeenat
Published: July 2018

In this 21st century, Lyophilization emerges to be a novel trend for the drying of pharmaceuticals and biological that are thermolabile or are unstable in aqueous form but stable for longer periods in their dried form. This article provides an overview on the process of lyophilization, how the freeze drying cycle is designed, discussing several important parameters which are important for understanding of this process as well as their role in the designing of an optimized freeze drying cycle, so that a robust and economical process of lyophilization can be developed which does not impact the product quality. It also describes the use of this process in various industries.
STATUS OF A---T POLYMORPHISM IN EXON II OF KINASE INSERT DOMAIN GENE IN WOMEN WITH PREMATURE OVARIAN FAILURE
Authors: Hasan RGB Ali H. , M. Sujatha
Published: July 2018

Ovarian failure is defined as cessation of ovarian function under the age of 40 and it is characterized by amenorrhea hypo estrogenism and elevated gonadotrophin serum levels leading to infertility. Ovarian failure affects 1% of women. Causes of ovarian failure are extremely heterogenous. Ovarian failure is caused either by accelerated loss of eggs or the follicles themselves become less responsive to hormonal stimulation. It is high levels of gonadotrophins (luteinizing hormone and follicle stimulating hormone) hormonal defects may cause severe cardio vascular consequences and leads to the early onset of osteoporosis. Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. VEGF is involved in the process of angiogenesis for the development of Graffian follicle an important feature of growing follicle which has been arrested in the primordial follicular stage .VEGF mediates the process of angiogenesis through its receptors I and II.. Receptor II is known as Kinase insert domain receptor, is a type III receptor tyrosine Kinase.KDR is located at 4q11-q12.The main objective of this study was to screen the mutations in Kinase insert domain by using the techniques DNA isolation, Polymerase chain reaction and restriction fragment length polymorphism.
METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UPLC ASSAY METHOD FOR NIFEDIPINE
Authors: Bhardwaj Shalini , Gupta M. K. , Bhalla V.
Published: July 2018

A simple and rapid stability indicating, ultra performance liquid chromatographic (UPLC) method was developed and validated for the determination of Nifedipine. The quantitative determination of Nifedipine drug was performed on a Sunniest C-18-HT, 2m, (50 2.1nm) column with gradient elution. For UPLC method, UV detection was made at 335nm. During method validation, parameters such as precision, linearity, stability, robustness and specificity were evaluated, which remained within acceptable limits. Forced degradation studies of Nifedipine were studied under acidic and alkaline stress conditions. Mild degradation of the drug substance was observed during acidic hydrolysis and no degradation was observed during basic hydrolysis.
Reklama suplementów diety – analiza prawna
Authors: Książczak Karolina , Nieścior Bartosz
Published: July 2018

Celem niniejszego artykułu jest analiza prawna reklamy suplementów diety i problemów jakie napotykają konsumenci oraz przedsiębiorcy z uwagi na brak kompleksowego uregulowania przedmiotowych produktów. Nacisk został położony na przeanalizowanie aktów prawnych ustanowionych na poziomie Unii Europejskiej oraz aktów obowiązujących w prawie krajowym, a także przykładach zastosowania powyższych regulacji w orzecznictwie sądów oraz decyzji kompetentnych organów. W obliczu częstych problemów z zastosowaniem się do przepisów właściwych suplementom diety, analiza taka okazuje się niezbędna dla porównania różnych reżimów prawnych rządzących reklamą suplementów diety oraz kompleksowego uregulowania dotyczącego produktów leczniczych.
Konkurencyjność gospodarki województwa małopolskiego a rozwój ekosystemu startupowego
Authors: Piecuch Jakub , Szarek Joanna
Published: July 2018

W XXI wieku konkurencyjna gospodarka regionu jest gospodarką opartą na wiedzy i nowych technologiach. Przedsiębiorstwa typu startup wraz z ekosystemem startupowym stały się wyznacznikiem innowacyjności regionu. Artykuł ma na celu ukazanie zależności pomiędzy rozwojem krakowskiego środowiska startupowego a wzrostem konkurencyjności województwa małopolskiego. Za podstawowe czynniki oddziałujące na konkurencyjność Małopolski uznano liczbę udzielonych patentów na wynalazki krajowe przez Urząd Patentowy RP, dynamikę zatrudnienia w B+R, nakłady inwestycyjne na B+R, liczbę przedsiębiorstw z kapitałem zagranicznym oraz PKB per capita w cenach bieżących. Po przeprowadzonej analizie korelacji wykazano, że najsilniejsze zależności zachodzą pomiędzy PKB per capita w cenach bieżących a liczbą przedsiębiorstw z kapitałem zagranicznym oraz nakładami inwestycyjnymi na B+R. Główny ośrodek miejski, jakim jest w analizowanym obszarze Kraków, stał się magnesem skupiającym wokół siebie osoby zakładające startupy, budujące innowacyjną gospodarkę oraz całe zaplecze biznesowe. Krakowski ekosystem startupowy ma pozytywny wpływ na konkurencyjność regionu małopolskiego z uwagi na gromadzenie wysoko wykwalifikowanego kapitału społecznego, krajowych i zagranicznych inwestorów, fundacji i instytucji wspierających pomysłodawców w zmaterializowaniu idei, działalności instytucji i administracji publicznej w kierunku współpracy z obszarem nauki i biznesu.
Zmiany w polskim handlu zagranicznym produktami rolno spożywczymi z Federacją Rosyjską w latach 2006-2015
Authors: Batyk Iwona
Published: July 2018

Celem artykułu jest wskazanie najważniejszych zmian w polskim handlu zagranicznym produktami rolno-spożywczymi z Federacją Rosyjską w latach 2006-2015. Do weryfikacji celu wykorzystano analizę zmian w czasie oraz analizę struktury handlu zagranicznego produktami rolno-spożywczymi w latach 2006-2015. Artykuł jest wynikiem analizy literatury i opracowań statystycznych. Zastosowane dane pochodzą z Roczników Statystycznych Handlu Zagranicznego. Wymianę handlową towarami rolno-spożywczymi charakteryzuje znaczna przewaga eksportu z Polski do Rosji nad importem. Wartość obrotów istotnie zmniejszyła się po wprowadzeniu w 2014 r. przez Federację Rosyjską ograniczeń w imporcie tych produktów z krajów Unii Europejskiej. Dynamika eksportu do Rosji zależna była od kategorii towarów. Największe zmiany dotyczyły produktów pochodzenia roślinnego i zwierzęcego, ponieważ ich eksport obarczony był wysokim stopniem barier handlowych, wynikających przede wszystkim z sytuacji geopolitycznej. Do poprawy polsko-rosyjskich relacji gospodarczych i handlowych konieczna jest akceptacja przez Rosję norm unijnych na produkcję oraz certyfikację weterynaryjną i fitosanitarną produktów rolno-spożywczych.
Przewagi komparatywne w handlu zagranicznym Polski na przykładzie produktów rolno-spożywczych i pozostałych
Authors: Szczepaniak Iwona
Published: July 2018

Globalizacja i integracja gospodarcza sprawiają, że konkurencyjność podmiotów coraz częściej analizowana jest w kontekście ich powiązań z rynkiem międzynarodowym. Celem artykułu jest ocena przewag komparatywnych w handlu zagranicznym Polski produktami rolno-spożywczymi na tle handlu pozostałymi produktami. W badaniu wykorzystano wskaźnik relatywnej przewagi handlowej RTA. Badanie to poprzedzono omówieniem wyników handlu zagranicznego. Źródłem danych była baza danych handlowych WITS-Comtrade. Analizę przeprowadzono na poziomie sekcji HS. Badanie udowodniło, że handel zagraniczny Polski charakteryzuje zróżnicowany poziom przewag komparatywnych. Spośród dwudziestu sekcji HS, w 2016 r. Polska posiadała przewagi komparatywne w handlu produktami dwóch rolno-spożywczych i siedmiu pozostałych sekcji. Na sekcje te przypadało odpowiednio ok. 9% i 50% wartości obrotów handlowych Polski. Rozwój handlu zagranicznego produktami rolno-spożywczymi Polski, a także dość znaczące przewagi komparatywne w handlu tymi produktami wskazują na konkurencyjność i duże znaczenie polskiego sektora rolno-spożywczego dla gospodarki narodowej.
Rozwój sektora rolnego w Polsce i krajach Unii Europejskiej
Authors: Szczukocka Agata
Published: July 2018

Rola i znaczenie sektora rolnego ulega zmianom w procesie rozwoju społeczno-gospodarczego. Pomimo zachodzących zmian rolnictwo w Polsce nadal jest ważnym sektorem gospodarki, a Polska jest znaczącym producentem żywności. W artykule podjęto próbę oceny rozwoju sektora rolnego w Polsce według województw oraz w krajach Unii Europejskiej wykorzystując wskaźniki ekonomiczne. Przeprowadzono analizę dynamiki zmian w poziomie zatrudnienia i wartości dodanej brutto w ujęciu trzech sektorów. Zastosowanie do badania syntetycznej miary rozwoju umożliwiło dokonanie oceny poszczególnych województw oraz krajów Unii Europejskiej z punktu widzenia rozwoju sektora rolnego. Badanie wykazało, że w ostatnich latach rola sektora rolnego w Polsce i krajach Unii Europejskiej uległa zmniejszeniu. Poza tym zaobserwowano duże zróżnicowanie w rozwoju rolnictwa w układzie województw oraz w krajach Unii Europejskiej.
Ubóstwo w Polsce i Unii Europejskiej a formy jego przezwyciężania w kontekście zrównoważonego rozwoju i doświadczeń UE
Authors: Biernat-Jarka Agnieszka , Trębska Paulina
Published: July 2018

Celem artykułu jest ocena zjawiska ubóstwa w Polsce na tle innych krajów Unii Europejskiej oraz scharakteryzowanie wybranych form przezwyciężania ubóstwa w kontekście zrównoważonego rozwoju. W artykule dokonano przeglądu literatury z tego obszaru oraz analizy źródeł wtórnych pochodzących z Głównego Urzędu Statystycznego i EUROSTAT. Ubóstwo jest zjawiskiem powszechnym i występuje we wszystkich krajach Unii Europejskiej. Około 17% obywateli Unii Europejskiej jest zagrożonych ubóstwem. Problem ten powinien być rozwiązany ze względu na zrównoważony i trwały rozwój i jest to podstawą europejskiej strategii walki z ubóstwem i wykluczeniem społecznym.
Istota protekcjonizmu w dziewiętnastym wieku oraz współcześnie
Authors: Kłosowicz-Toborek Katarzyna
Published: July 2018

Pomimo działalności WTO idea protekcjonizmu jest wciąż aktualna. Większość państw oficjalnie opowiada się za liberalizmem, a przy tym ogranicza wymianę handlową. Działalność ta ulega nasileniu w okresach stagnacji gospodarczej oraz w związku z różnicami rozwojowymi między uczestnikami rynku światowego. To właśnie zacofanie gospodarcze XIX-wiecznych Niemiec wpłynęło na stworzenie wielu oryginalnych myśli, a wśród nich tych, które odnosiły się do sposobu prowadzenia handlu zagranicznego. Warto zatem zbadać i porównać neoprotekcjonizm z protekcjonizmem prezentowanym przez XIX-wiecznych ekonomistów. Analiza współczesnego i XIX-wiecznego protekcjonizmu wskazuje, że istota tych pojęć nie różni się bowiem neoprotekcjonizm i jego XIX wieczny odpowiednik realizują te same cele, aczkolwiek przy wykorzystaniu innych środków.
(p,q)-Bivariate-Bernstein-Chlodowsky operators
Authors: Rao Nadeem , Wafi Abdul
Published: July 2018

In this article, we construct Bivariate-Bernstein-Chlodowsky operators based
on (p,q)-integers. We give the basic estimates for these operators.
Moreover, we discuss rate of convergence and pointwise approximation in
Lipschitz class. In the last, we prove weighted approximation results.
Geodesic mappings of manifolds with affine connection onto the Ricci symmetric manifolds
Authors: Berezovskii Volodymyr , Hinterleitner Irena , Mikes Josef
Published: July 2018

In the present paper we investigate geodesic mappings of manifolds with affine
connection onto Ricci symmetric manifolds which are characterized by the
covariantly constant Ricci tensor. We obtained a fundamental system for this
problem in a form of a system of Cauchy type equations in covariant
derivatives depending on no more than n(n+1) real parameters. Analogous
results are obtained for geodesic mappings of manifolds with affine
connection onto symmetric manifolds.
A Galerkin-like approach to solve multi-pantograph type delay differential equations
Authors: Yüzbaşı Şuayip , Karaçayır Murat
Published: July 2018

In this paper, a Galerkin-like approach is presented to numerically solve
multi-pantograph type delay differential equations. The method includes
taking inner product of a set of monomials with a vector obtained from the
equation under consideration. The resulting linear system is then solved,
yielding a polynomial as the approximate solution. We also provide an error
analysis and discuss the technique of residual correction, which aims to
increase the accuracy of the approximate solution. Lastly, the method, error
analysis and the residual correction technique are illustrated with several
examples. The results are also compared with numerous existing methods from
the literature.
Global existence and stability results for mild solutions of random impulsive partial integro-differential equations
Authors: Vinodkumar A. , Indhumathi P.
Published: July 2018

In this paper, we discuss the global existence, uniqueness, continuous
dependence and exponential stability of random impulsive partial
integro-differential equations is investigated. The results are obtained by
using the Leray-Schauder alternative fixed point theory and Banach
Contraction Principle. Finally we give an example to illustrate our abstract
results.
Hankel determinant for a subclass of bi-univalent functions defined by using a symmetric q-derivative operator
Authors: Srivastava H.M. , Altınkaya Şahsene , Yalçın Sibel
Published: July 2018

In this paper, we discuss the various properties of a newly-constructed
subclass of the class of normalized bi-univalent functions in the open unit
disk, which is defined here by using a symmetric basic (or q-) derivative
operator. Moreover, for functions belonging to this new basic (or q-) class
of normalized biunivalent functions, we investigate the estimates and
inequalities involving the second Hankel determinant.
Localization theorems for matrices and bounds for the zeros of polynomials over quaternion division algebra
Authors: Ahmad Sk. , Ali Istkhar
Published: July 2018

In this paper, we derive Ostrowski and Brauer type theorems for the left and
right eigenvalues of a quaternionic matrix. Generalizations of Gerschgorin
type theorems are discussed for the left and the right eigenvalues of a
quaternionic matrix. After that, a sufficient condition for the stability of a
quaternionic matrix is given that generalizes the stability condition for a
complex matrix. Finally, a characterization of bounds is derived for the
zeros of quaternionic polynomials.
An integral representation, complete monotonicity, and inequalities of the Catalan numbers
Authors: Qi Feng , Shi Xiao-Ting , Liu Fang-Fang
Published: July 2018

In the paper, by virtue of the Cauchy integral formula in the theory of
complex functions, the authors establish an integral representation for the
generating function of the Catalan numbers in combinatorics. From this, the
authors derive an alternative integral representation, complete
monotonicity, determinantal and product inequalities for the Catalan
numbers.
Trees with equal total domination and 2-rainbow domination numbers
Authors: Shao Zehui , Sheikholeslamib Seyed , Wang Bo , Wu Pu , Zhang Xiaosong
Published: July 2018

A 2-rainbow dominating function (2RDF) of a graph G is a function f : V(G) ?
P({1,2}) such that for each v ? V(G) with f (v) = ? we have Uu?N(v) f (u)
= {1,2}. For a 2RDF f of a graph G, the weight w(f) of f is defined as w(f)=?v?V(G)?f(v)?.
The minimum weight over all 2RDFs of G is called
the 2-rainbow domination number of G, which is denoted by ?r2(G). A subset S
of vertices of a graph G without isolated vertices, is a total dominating
set of G if every vertex in V(G) has a neighbor in S. The total domination
number ?t(G) is the minimum cardinality of a total dominating set of G.
Chellali, Haynes and Hedetniemi conjectured that ?t(G)? ?r2(G) [M. Chellali,
T.W. Haynes and S.T. Hedetniemi, Bounds on weak Roman and 2-rainbow
domination numbers, Discrete Appl. Math. 178 (2014), 27-32.], and later
Furuya confirmed the conjecture [M. Furuya, A note on total domination and
2-rainbow domination in graphs, Discrete Appl. Math. 184 (2015), 229-230.].
In this paper, we provide a constructive characterization of trees T with
?r2(T) = ?t(T).
A multiplicity results for a singular problem involving a Riemann-Liouville fractional derivative
Authors: Ghanmi A. , Kratou M. , Saoudi K.
Published: July 2018

In this work, we investigate the following nonlinear singular problem with
Riemann-Liouville Fractional Derivative (P?) {-tD?1(?0D?t
(u(t))?p-2 0D? tu(t)) = g(t)/u?(t) + ?f (t,u(t)) t ? (0,T); u(0) = u(T)
= 0, where ? is a positive parameter, p > 1, 1/2 < ? ? 1,0 < ? < 1, g ?
C([0,T]) and f?C([0,T] x R,R). Under appropriate assumptions on the
function f, we employ the method of the Nehari manifold combined with the
fibering maps in order to show the existence of ?0 such that for all ? ?(0,?0) the problem (P?) has at least two positive solutions. Finally, some
examples are given to illustrate our results.
Essential norm of weighted composition operators from the Bloch space and the Zygmund space to the Bloch space
Authors: Hu Qinghua , Li Songxiao
Published: July 2018

In this paper, we give some estimates for the essential norm of weighted
composition operators from the Bloch space and the Zygmund space to the
Bloch space.
Forward and inverse predictions of deformations in laser forming of shaped surfaces under coupling mechanism
Authors: Maji Kuntal , Pratihar D. K. , Nath A. K.
Published: July 2018

This article deals with out-of-plane and in-plane deformations of an American Iron and Steel Institute 304 stainless steel sheet in laser forming under the coupling mechanism, which is required to make any three-dimensional (3D) part from a flat sheet. Experiments were carried out based on face centered central composite design of experiments to develop statistical regression models based on experimental data for both the types of deformations, i.e., in-plane and out-of-plane, as a function of input parameters, such as laser power, scan speed, and spot diameter. Adaptive neuro-fuzzy inference system-based models were also developed to predict bending or out-of-plane and thickening or in-plane deformations. Process synthesis or inverse analysis, that is, to decide the process parameters to laser form a 3D shape from flat sheet metal was performed using an adaptive neuro-fuzzy inference system. Prediction accuracy of the developed models was verified through experiments and good correlation was found in estimating deformations and process parameters for both forward and inverse analyses. The effect of Fourier number on deformation in making a three-dimensional surface was also studied, and it was found to be an important factor in obtaining a three-dimensional shape with desired accuracy.
Leituras espaciais plurais por meio da cartografia aplicados à análise do patrimônio urbano arquitetônico em Goiânia, Goiás.
Authors: Ramos de Castro Raquel de Albuquerque Franco
Published: July 2018

A cartografia tornou-se fonte usual do imaginário da sociedade contemporânea, de forma interativa-globalizada, proporcionando novas formas de relacionamento e geração de produtos palpáveis, assim como, formando um leitor crítico da cidade. Neste trabalho, objetiva-se reunir um aporte teórico-metodológico que permita leituras espaciais plurais e o mapeamento (social/temático) aplicados à percepção da paisagem urbana; tendo como cenário o centro de Goiânia, numa perspectiva do Patrimônio Cultural Edificado considerando o contexto das manifestações sociais de grafite e pichação. Para tanto, percorre-se uma metodologia de elaboração de mapas, tendo como base o mapa mental e sua posterior sistematização, em uma dinâmica de alfabetização cartográfica e leitura espacial, em 7 estágios, do 1º ao 4º a criação do mapa e do 5º ao 7º sua utilização. Observa-se que o leitor-mapeador amplia a percepção das paisagens, reforçando o sentido de lugar, bem como poder e capacidade de ações sociais integradas ao prazer de estar urbano transmitidos. Com isso, pensa-se que a linguagem cartográfica ampliada e crítica é indissociável dos processos e ciências que estudam o espaço, permitindo uma leitura que atenda às modificações e permanência que neste ocorrem. O pensar geográfico, proporcionado por tais métodos, coadunado aos conhecimentos dos conceitos espaciais (desta ciência) pode embasar saberes científicos que fundamentam o trabalho dos que estudam as cidades, como arquitetos urbanistas.
On the feasibility and possibility of heating water for district heating systems through the use of heat of the main condensate after cogeneration turbines
Authors: Orlov M. E. , Zamaleev M. M. , Kuz’min A. V. , Sharapov V. I.
Published: July 2018

The possibilities of increasing the efficiency of cogeneration turbines of CHP plants through the use of low-potential heat carriers for water heating in district heat supply systems and increasing the generation of CHP electricity are considered. The existing technologies of heating the makeup water of the district heating system upstream water treatment apparatuses do not always provide the required heating temperature and do not have the sufficient energy efficiency. The technologies of using the main condensate of the exhaust steam in the turbine to heat the feed water in additional heaters included in the system of regeneration of cogeneration turbines are developed. The use of these technologies contributes to increasing the flow rate and reducing the enthalpy of the steam of regenerative outlets of the turbine used to heat this condensate, and, therefore, increases the combined heat and power generation. In order to determine the industrial applicability of the proposed solutions, experimental studies of the regeneration systems of turbo-units under the conditions of Ulyanovsk СHPPs-1 have been carried out. Multiparameter data arrays on operation of turbine condensate-feed path have been collected, and regression equations have been obtained to calculate the main condensate flow temperatures depending on various factors. On the basis of experimental data there have been calculated the minimum and maximum flow rates of feed water that can be heated to the desired temperature in the surface heaters included in the regeneration system of the turbines, the flow graphs of the heated feed water are constructed depending on the temperature of the main condensate after the turbines. The fields of application of the proposed technological solutions in operating heat supply systems are defined. The evaluation of energy efficiency is carried out using the method of specific generation of CHP electricity and conventional fuel economy at the implementation of the proposed solutions is calculated.
On the system of ensuring electrical safety of maintenance works performed on 35 – 750 kV power transmission lines being under induced voltage implemented in the Republic of Belarus
Authors: Drako M. A. , Korotkevich A. M. , Porshnev V. N.
Published: July 2018

The article studies the matters of physics of interaction of parallel overhead power transmission lines. Cases are presented, where the maximum induced voltage values are expected on individual sections of closely approaching de-energized and energized power transmission lines. Possible scenarios are presented of direct contact with an unearthed conductor (wire) of OPL in the normal operation mode. Substantiation is presented of review of the list of the lines, which, when de-energized or earthed at terminal sections (in the switchgear of substations and power plants) have the values of induced voltage on the earthed conductors, as reduced to the maximum permissible continuous current of the affecting OPL, exceeding 25 V . Criteria are identified to classify OPL as being affected by induced voltage. The article considers organizational and technical procedures applied to provide safe maintenance works under induced voltage on de-energized overhead power lines (OPL) located within an area affected by energized OPL.  Attention is given to the detailed description of types of earthing of OPL, line equipment, working section and workplaces used by State Production Association Belenergo. The mathematical apparatus used in the analytical calculations of the induced voltage values has been analyzed. The technical implementation of acceptable schemes of performing the repair and maintenance works on the earthing of de-energized OPL is considered. Performing geophysical ground survey by the method of vertical electrical sounding at places of mounting special low-resistance earthing electrodes is proposed and implemented. The methodology is developed and tested for measuring induced voltage values, which sets the order of induced voltage measurements on de-energized OPL running close to energized OPL with the voltage 110 kV, and higher. Comparative analysis is presented of results of analytical calculations and experimental research. Conclusions are made supporting the approach adopted and confirming the expediency of the system of ensuring electrical safety of maintenance works performed on 35–750 kV power transmission lines being under induced voltage implemented in the Republic of Belarus.
Exposição ao ruído ocupacional em trabalhadores de um posto de combustível em Formiga – MG
Authors: Sales Ronan Souza , Dos Santos Danielle , Chiesa Karoline Santos , Pimenta Brandon Pinheiro
Published: July 2018

Introdução: Qualquer atividade, cotidiana ou não, gera um determinado nível de ruído, ou seja, gera um resíduo sonoro poluente para o meio ambiente. Torna-se assim de suma importância estudos sobre a exposição de trabalhadores ao ruído ocupacional, afim de se preservar a saúde destes. Objetivo: Avaliar o nível de ruído ao qual estão expostos os funcionários de um posto de combustível localizado na cidade de Formiga - MG através da quantificação da dose e comparar com a legislação. Metodologia: A quantificação da dose de ruído foi realizada através do dosímetro DOS 600. Foram quantificadas doses de ruído em diferentes jornadas e trabalho e diferentes funcionários trabalho. Posteriormente foi comparado os valores obtidos com a legislação vigente no país. Resultados: De acordo com a metodologia utilizada o menor valor de dose encontrada foi de 26,9% e o maior valor foi de 58,0%. Conclusão: Todos os valores obtidos encontram-se se encontram dentro dos limites estabelecidos pela legislação vigente no país.
Memória e Esquecimento: uma relação indissociável nos relatos de mulheres que sobreviveram ao maior genocídio do século XX, o Holocausto
Authors: Arantes Sandra de Almada Mota
Published: July 2018

RESUMO
Introdução: Este artigo é uma reflexão sobre mulheres sobreviventes da Segunda Guerra Mundial, assunto que, hoje, tem sido mais discutido e contribuído para a reconstrução de uma história. Mulheres sobreviventes do período do Holocausto, o maior genocídio do século XX, buscam recuperar sua história e o fazem ao acessar as essências perdidas no tempo, que poderão, via memória e lembranças, reviver o tempo passado ou o tempo em que se passaram. Objetivo: refletir sobre os relatos daquelas que sobreviveram ao Holocausto, e, a partir da relação indissociável memória/esquecimento, buscar entender os silenciamentos e o relato da dor, a superação para reedificação da vida após o trauma, e a possibilidade de recomeçar a escrita de uma história. Metodologia: para a fundamentação da escrita, realizou-se o levantamento bibliográfico a partir da análise de fontes que abordam, de diferentes maneiras, o tema. Dentre elas os livros, os artigos, os periódicos, textos disponíveis em sites confiáveis, locais que apresentam um conteúdo documentado. Conclusão: Os relatos mostram a possibilidade de traduzir a experiência do extermínio e consolidar um compromisso com as narrativas na intenção de fazer conhecido pelo maior número possível de pessoas o que aconteceu a elas a fim de que todo o sofrimento e violência não sejam esquecidos e não se repitam.
 
Palavras-chave: Mulheres; História; Memória; Violência sexual feminina.