bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kejahatan dan Hukuman tehadap Tantangan Deterministik Kausal secara Sosial yang Menyebabkan Pertanggungjawaban Pidana
Authors: Ahyani Hisam , Makturidi Muhamad Ghofir , Sa’diyah Farhatun , Kasih Dien Kalpika , Putra Haris Maiza
Published: January 2023

Kejahatan dan hukuman merupakan 1) sebuah perilaku, 2) salah satu jenis gejala sosial dalam interaksi yang terbangun antar manusia, 3) Fenomena alam dan sosial, 4) termasuk interaksi antara orang-orang dalam kehidupan sosial, 5) dianggap sebagai proses mekanis deterministik berdasarkan hukum kausalitas. Sehingga dewasa ini kajian kejahatan dan hukuman perlu dikembangkan guna mewujudkan pembangunan Nasional. Metode penelitian ini merupakan penelitian normatif dimana deterministic kausal bertujuan dalam pemidanaan dan tidak hanya didasarkan pada konsep keadilan retributif, tetapi juga pada prinsip manfaat yang dihasilkan dalam arti bertujuan untuk mencegah terulangnya kejahatan serupa dan dengan demikian dapat menciptakan ketertiban dan keamanan Nasional. Hasil penelitian menunjukkan bahwa kejahatan dan hukuman tehadap tantangan deterministik kausal secara sosial yang menyebabkan pertanggungjawaban pidana adalah sebuah keniscayaan sebagaimana Satjipto Rahardjo mengungkapkan bahwa hukum selalu berkembang mengikuti perkembangan manusia serta mengikuti kebutuhan dan nilai-nilai yang hidup dalam manusia untuk mewujudkan keadilan sosial bagi seluruh warga Negara Indonesia.
Reformulasi Hukum Penguatan Koperasi Syariah di Indonesia
Authors: Panggabean Ruben
Published: January 2023

Reformulasi hukum penguatan Koperasi Syariah di Indonesia dilakukan dengan pembuatan peraturan pelaksana UU  No 1 Tahun 2013 sebagai sarana mewujudkan kepastian hukum dan perlindungan hukum bagi masyarakat baik selaku penyimpan dan pengguna di sektor Lembaga Keuangan Mikro. Pasca diundangkannya UU No 1 Tahun 2013 hingga saat ini pemerintah belum juga mengesahkan peraturan pelaksana UU tersebut. Hal itu, membuat belum efektifnya pelaksanaan UU 1 Tahun 2013 yang menjadi payung hukum bagi legalitas operasional Lembaga Keuangan Mikro serta perlindungan bagi masyarakat selaku penyimpan dan peminjam dana. Terdapat dua bentuk koperasi di Indonesia yang pertama adalah koperasi konvensional yang diatur dalam UU 25 Tahun 1992 Tentang Perkoperasian dan yang kedua adalah koperasi syariah (Baitul Maal Tamwil) yang diatur dalam UU No 1 Tahun 2013 tentang Lembaga Keuangan Mikro. Koperasi adalah organisasi bisnis yang dimiliki dan dioperasikan oleh orang-seorang demi kepentingan bersama. Koperasi melandaskan kegiatan berdasarkan prinsip gerakan ekonomi rakyat yang berdasarkan asas kekeluargaan. Koperasi tumbuh dari kalangan rakyat, ketika penderitaan dalam lapangan ekonomi dan sosial yang ditimbulkan oleh kapitalisme semakin memuncak. Hukum mempunyai peranan untuk menciptakan kedamaian dan kedamaian itu merupakan konsep yang menjamin keselarasan antara ketertiban yang bersifat lahiriah dan ketentraman yang bersifat batiniah. Hukum tidak lagi dilihat sebagai refleksi kekuasaan semata-mata, tetapi juga harus memancarkan perlindungan terhadap hak-hak warga negaranya.

                Kata kunci : Koperasi Syariah; Lembaga Keuangan Mikro; Perlindungan; Reformulasi.
Analisis Determinan Faktor Lingkungan Fisik terhadap Upaya Pencegahan Penyakit Akibat Kerja (PAK) di Industri Papan Semen Cor
Authors: Prabarini Purnaning Wahyu , Handini Amira Putri , Setyawan Febri Endra Budi , Tunjungsari Feny
Published: January 2023

Occupational diseases still contribute to high mortality rates. Physical environment will always be encountered by workers so the risk of exposure will be higher. Physical Environment hazard can cause occupational disease due to work and affect losses both workers and company seriously. The purpose of this study is to analyze correlation between the determinants of physical environment factor with the efforts to prevent occupational disease in the Cast Cement Board Industry, Malang Regency.Observasional-analytic with cross-sectional method was conducted to determine the association between determinants of physical environment factors with the efforts to prevent occupational disease in the Cast Cement Board Industry, Malang Regency. A total sample size of 188 workers were included in this study. Data collection was done directly through questionnaires. To process the data, SEM-PLS (Structural Equation Modelling - Partial Least Square) analysis was conducted.The result showed that there was an correlation between physical environment factors in workers with the efforts to prevent occupational disease (P= 2,683, P>1,96) and there was also a significant correlation between noise (P= 6,029, P> 1,96) and climate (P=4,592, P> 1,96) with the efforts to prevent occupational disease.This study concludes that there is a significant relationship between physical environment factors with the efforts to prevent occupational disease.
Peran Karotenoid Sebagai Pencegahan Degenerasi Makula
Authors: Putri Aryani Vindhya , Nurmalina Nabila , Sylvestris Alfa , Hanifwati Annisa
Published: January 2023

Macular degeneration or often called Age-related Macular Degeneration (AMD) is a degenerative disease that attacks the center of vision in the retina, namely the macula. In an effort to prevent the progression of AMD, consuming antioxidants has been shown to inhibit the AMD development process. Although currently there is no definite number of AMD sufferers in Indonesia, it is estimated that the number of AMD sufferers will continue to increase. Carotenoids are one of the antioxidant compounds that have been shown to inhibit the development of macular degeneration. Carotenoids are divided into several classes, one of which is the xanthophyll class. Lutein and zeaxanthin compounds belong to the xanthophyll class. The content of lutein and zeaxanthin in body plasma has been shown to reduce the risk of macular diseases such as AMD. This study aims to determine the role of carotenoids as the prevention of macular degeneration. The method used is a literature review in the form of a narrative review. Search literature in the form of journals and textbooks through Google Scholar, PubMed, Science Direct, and Research Gate, indexed by Scopus, ISSN, national journals and international journals. The journals used were published in the last 5 years and books published in the last 10 years. The results of the analysis show that carotenoid antioxidants are proven to be able to act as a prevention of AMD by reducing oxidative stress. Carotenoids will quench free radicals, thereby preventing the occurrence of lipid peroxidation, and preventing the formation of AMD. Carotenoids also prevent damage mediated by exposure to blue light. Consumption of lutein and zeaxanthin can also reduce the expression of VEGF (vascular endothelial growth factor) in the retina so that it can inhibit the increase of VEGF. It can be concluded that carotenoid antioxidants can prevent the progression of macular degeneration.
Pengaruh Konseling Gizi Terhadap Kepatuhan Diet dan Kadar Gula Darah Sewaktu Pada Pasien Diabetes Melitus Tipe 2
Authors: Kusumastuti Hellen , Widiyawati Agatha , Yohan Yuanta
Published: January 2023

Type 2 diabetes mellitus is one of the incurable non-communicable diseases characterized by an uncontrolled increase in blood sugar levels. Type 2 diabetes mellitus requires proper management to prevent complications. The basic part of managing type 2 diabetes mellitus is nutrition counselung, with nutrition counseling can help patients in making decisions such as dietary arrangements in accordance with 3J (amount, schedule and type) and managing blood sugar levels. The purpose of this study analyzed the effect of nutritional counselung on detary complience and blood sugar levels in type 2 DM patients in kebondalem health centers. This research method is quasi experimental designs with a non-equvalent control group research design. The large number of subjects in this study was 20 people counsiting of 10 control group people and 10 experimental group people with Purposive sampling technique. Static analysis of this study using the Wilcoxon Test and Mc Nemar Test. Result showed that there was no influence of nutritional counseling on dietary compliance seen froom 3J (amount, type and schedule) in the control group while in the experimental group it showed the influence of nutritional counseling on the amount of protein and the amount of carbohidrates, but there was no effect of nutritional counseling on the amount of energy, fat, schedule and type in the experimental group, as well as the effect of nutritional counseling on blood sugar levels in the control group did not significanty and in experimental groups significanty.
Review Artikel: Pengaruh Diet Semangka Merah (Citrullus lanatus) terhadap VO2Max
Authors: Hanifwati Annisa , Pawestri Ajeng Salsabilla , Cakrawati Hanna , Illahika Anung Putri
Published: January 2023

Technological rapidly developments influence in lifestyle changes of people who do sedentary lifestyles. Lack of physical activity can reduce the value of VO2max, so that will impact on lowering physical fitness index. Value of VO2max can be increased through consumption of red watermelon (Citrullus lanatus) that is contained citrulline. Red watermelon is the richest source of citrulline compared to other fruits or vegetable on cucurbitaceae plants. Substance of citrulline that enters the body is converted to nitric oxide (NO) which can increase VO2max through the mechanism of oxidative phosphorylation in mitochondria. This study is to know the effect of red watermelon (Citrullus lanatus) to VO2max. This paper is a qualitative study of literature. Bibliography like articles and literature books were obtained through the Elsevier, PubMed, Cochrane Library, and Google Scholar search engines. The result of analysis shows that the consumption of red watermelon (Citrullus lanatus) affects of VO2max enhancement. Nutrients of citrulline, which is contained in red watermelon, increases NO bioavailability and has an effect on increasing VO2max. In conclusion consumption of red watermelon juice (Citrullus lanatus) affects to value of VO2max.
There’s Something About SALL: A Response to Gardner and Miller
Authors: Everhard Carol J.
Published: January 2023

This article is a response to the review article written by Gardner and Miller (2021) in relation to the state of the art in self-access at the time of the publication of their book (Gardner & Miller, 1999) and the progress and development of self-access since then. By way of response, this article examines and embellishes on some of the themes they explore in relation to the past, present and future of self-access learning and suggests some other possible themes worthy of note and consideration. This author concludes, as do they, that self-access as we currently know it and in forms still to be defined will remain with us for quite some time to come.
Helping a language learner gain self-confidence and awareness through advising
Authors: Hiney Gráinne
Published: January 2023

Learners can develop both their autonomy and reflection skills by becoming involved in advising in language learning. Advising is a relatively new field in language teaching and learning, though the value of advising is increasingly recognised. Using narrative inquiry, this short reflective paper describes an online advising session conducted with a Finnish student in the University of Helsinki, Finland. The session focused on building self-confidence and awareness. Analysis of the session indicated that the student experienced immediate short-term benefit, with strong potential for future long-term benefit, both personally and regarding language learning.
FAKTOR-FAKTOR YANG MEMPENGARUHI PERTUMBUHAN TOTAL ASET PERBANKAN SYARIAH DI INDONESIA
Authors: Aryanti Rani Tri , WAHYUDI ROFIUL
Published: January 2023

This study aims to determine the internal and external factors that affect the growth of total Islamic banking assets in Indonesia. The data used in this study came from the published financial statements of each Islamic bank. The analytical method used in this study is annual time series data from 2016 to 2020. This study uses a causal quantitative approach. The sampling technique used is purposive sampling. The variables used in this study are Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR), Non-Performing Financing (NPF), Third Party Funds, Gross Domestic Product, Interest Rates, and Inflation. The analytical method used is Multiple Linear Regression Analysis. The results showed that partially internal factors, only CAR and DPK , had a significant effect on the growth of total assets; simultaneously, internal factors had a significant effect on the growth of total assets. Then the research results on external factors partially do not affect the growth of total Islamic banking assets. At the same time, it simultaneously does not affect the growth of total Islamic banking assets.
ANALISIS KUALITAS LAYANAN WEBSITE DAN PROMOSI E-COMMERCE TERHADAP KEPUTUSAN PEMBELIAN PRODUK PADA SHOPEE
Authors: Kurniawan Dendy , Siswanto Edy
Published: January 2023

This quantitative research was carried out with the object of research being shopee e-commerce users who were chosen randomly and at least had made a purchase of products or services once. While the number of population samples in this study were 100 people, the majority of whom were students. While the data collection technique using a google form questionnaire. The results obtained from data processing, show the multiple linear regression equation Y = 5.860+ 0.142X1 + 0.335X+e. There is a positive and significant effect of service quality on shopee product purchasing decisions, as evidenced by the value of a significant level of service quality of 0.002. There is also a positive and significant effect of promotion on product purchasing decisions at shopee, which is proven by the significant value below 0.002. F test obtained a significant level of 0.000. These results indicate that there is a joint influence between service quality and promotion on product purchasing decisions at shoppe because the value is below 0.05. while the value of determination is 0.578 or 57.8%. This can be interpreted that the quality of services and promotions affect product purchasing decisions on e-commerce shopee by 57.8, while the remaining 42.2% is influenced by other factors that are not included in the scrutiny.
ANALISIS KINERJA KEUANGAN PADA PERUSAHAAN MANUFAKTUR DI BIDANG INDUSTRI BARANG KONSUMSI
Authors: Barata Dion Dewa , Nainggolan Ferdinand , Prabowo Muhammad Ilham , Febiola Bella
Published: January 2023

Determine the financial performance of manufacturing companies in the consumer product industry sector listed on the Indonesia Stock Exchange for the year 2019 through 2021 is the goal of this study. Financial ratios, such as liquidity ratios, solvability ratios, and profitability ratios are utilized in the quantitative analysis of the data used. All manufacturing businesses that were listed on the Indonesia Stock Exchange between 2019 until 2021 make up the population of this research. The manufacturing firm in the consumer products industry sector, which is part of the LQ45 category, served as the study's sample. The findings indicated that PT. Indofood CBP Sukses Makmur Tbk had the best financial performances in terms of corporate liquidity. In terms of debt to equity ratio, PT. Indofood Sukses Makmur Tbk, have the best financial results. PT Unilever Indonesia Tbk, nevertheless, has the best financial results in terms of profitability.
LEGAL ANALYSIS OF MANGROVE DAMAGE COMPENSATION WITH ECONOMIC VALUATION IN BINTAN
Authors: Nuraini Lia , Irawan Henky , Sari Rizki Yuli
Published: January 2023

Bintan, the only conservation area at the district level, was established through the Regent's Decree No. 58/II/2009 and has an area of ​​472,905 ha, with a fairly high area of ​​mangroves and seagrass beds, especially in the southern region of Bintan Island. One interesting and sustainable phenomenon on Bintan Island is that beach destruction is often found in the form of lumps of dirty oil (sludge oil) during the north wind season along the northern coast of Bintan Island, stretching from Lagoi beach to Berakit beach. This study discusses the legal analysis of mangrove damage compensation with the economic valuation in Bintan. Research method This research uses empirical juridical research with qualitative and quantitative data types, from a qualitative perspective analyzing the legislation on the protection of mangrove ecosystems, and quantitative data analysis to measure the level of damage to mangroves in the Bintan area. The perpetrators of mangrove destruction can be subject to strict liability which imposes proof on the perpetrators. To provide a deterrent effect and save the environment as well as economic losses to Mangroves. Based on Ministerial Regulation Number 7 of 2014 concerning Environmental Losses Due to Pollution and/or Environmental Damage, describes community losses due to environmental damage, namely those that have an impact on community losses. Economic valuation of compensation due to mangrove destruction. As an ecotourism area in Bintan Regency, it can be calculated using the travel cost method, so that the action of the valuation in 1 month is as follows: Pengudang Village Tourism Rp. 20,000,000, Teluk Sebong Village Tourism Rp. 2,000,000, Penaga Village Tourism Rp. 29,040. 000, Lagoi Tourism Rp 834,000,000. The economic valuation due to mangrove damage in Bintan experienced by marginal fishermen is estimated at IDR 2,600,000 per month.
INDONESIA'S DEMOCRACY AND CONSTITUTION: REFLECTING HUMAN RIGHTS BASED ON PANCASILA
Authors: Putri Ria Wierma , Sabatira Febryani , Davey Orima Melati , Saputra Muhammad Febriyan , Natamiharja Rudi
Published: January 2023

Pancasila democracy is a democracy system applied in Indonesia to run the government based on the 1945 Constitution. The 1945 Constitution is positioned as the state constitution and is a concrete crystallization of Pancasila’s values. The constitution, which is the highest source of law in Indonesia, is very important in the Pancasila democratic system. The relationship between the Democracy, Human Rights, and Pancasila is very concord. Pancasila is the ideology of the Indonesian state, the basis of the state, and the foundation of the state philosophy. The relationship is contained in the values of Pancasila. These values highly uphold human rights which is seen from the second value of Pancasila, “fair and civilized humanity”. The relationship between democracy with human rights and Pancasila is that democracy is a system used in Indonesia to realize Pancasila’s values while still based on human rights in its implementation. Then, Pancasila must always remain the basis of the state’s philosophy because Pancasila is the result of the nation founders’ consensus agreement. Pancasila values are not owned by other countries in the world and has become the Indonesian nation’s identity. Pancasila is supreme because it is the core foundation in uniting the diverse Indonesian nation. In addition, ideals of law do not only function as a regulatory benchmark to test whether a positive law is fair, but it also serves as a constitutive ground. Therefore, laws will lose it definition without the existence of ideals of law.
THE ARTEMIS ACCORDS AND PROPERTY RIGHTS IN OUTER SPACE
Authors: Rivaldi Regi
Published: January 2023

On 13 October 2020, The National Aeronautics and Space Administration (NASA) and the representatives of eight other space-faring nations signed The Artemis Accords. The Accords is a set of 13 provisions to establish international collaboration on sustainable human exploration in outer space. The most controversial provision in the Accords is the provision in Section 10 that relates to exploiting space resources which is not inherent with Article II of The Outer Space Treaty and Article 11 of The Moon Agreement that will cause the implementation of the Artemis Accords may violate international law. The different interpretations in interpreting the provisions in Article II of The Outer Space Treaty raises questions related to property rights in outer space, especially on issues that are related to the extraction of natural resources. Is it part of the subject of the non-appropriation principle or not.
Aplikasi Sistem Manajemen Perpustakaan dengan Penerapan Pemrograman Berorientasi Objek
Authors: Jolie Angelina , Dedrick Dedrick , Sugeng Raphael Kurniawan , Lee Winona Audrey , Yulianto Andik
Published: January 2023

Library is one of the most important pillars to improve the quality of Indonesia’s education. Due to its importance for the next generation, the government tries to increase the establishment of schools and libraries so that the young generation can compete with people from another countries. However, the increasing number of libraries did not mean that the library service quality will become better. Many library systems in Indonesia still have not kept up with technology and still using the manual system, hence the management process and services are not effective. Because of that, this research is created for the purpose of producing a design for a library management application. The methods used in this research is split into multiple steps which is system planning, class diagram planning, MySQL database planning, and GUI planning. The following processes will produce a library management desktop application that is integrated to a database. With this application, processing, documenting, and deliverance of data can be done in more effective and efficient way.
Interrogating the Impact of Land Use/Land Cover Dynamics in Mbarara City in Southwestern Uganda
Authors: Nuwagira Upton , Yasin Igga , Nasasira Perfect
Published: January 2023

The urbanization in Mbarara City Southwestern Uganda has increased the number of built-up and small-scale agricultural areas thus escalating pressure on the grassland and woodlot areas hence influencing land fragmentation and slum development. In this study, we focused on land use/land cover dynamics. This helped us to identify land uses that reduce grassland areas, which increases land fragmentation, and slum development. Presumably, the land uses in the area included built-up areas, grassland, small-scale agriculture, and woodlots. Built-up, grassland, and small-scale agriculture were vital for our analysis. We employed remote sensing techniques (Supervised-Maximum Likelihood Classifier) with two cloud-free high-resolution images of 2010 and 2022 in mapping spatial-temporal patterns in built-up, grassland, and small-scale agriculture. Our results evidenced that built-up area increased by (5.14%), grassland declined by (7.1%), small-scale agriculture increased by (2.62%), and woodlots reduced by (0.73%) between 2010 to 2022 and the accuracy assessment for the image classification was (83%). Our study found that an increase in built-up areas and small-scale agriculture led to the decline of the grassland and woodlot areas between 2010 to 2022 with a statistically significant difference (p = 0.03). There was also a strong positive correlation (r = 0.97) between land use/land cover types in 2010 and 2022. Our study recommends that Mbarara City Authority should put strict laws and regulations governing the minimum size of land required during sub-division to avoid land fragmentation which results in increased slum development. Increased land fragmentation may have an intense impact on important ecosystems such as grasslands.
Teachers’ Concerns about Teaching – Learning Process
Authors: Avvaru Ramakrishna , Prusty Rojina , Narayana Rama Devi
Published: January 2023

Teachers are mainly concerned about education in general and specifically in teaching-learning process. There have been many studies on student teachers' concerns, but a very few on teachers' concerns about the teaching-learning process. According to their categorization of the teachers' concerns into three categories: self, task, and impact. Inservice teachers expressed more impact concerns than self- or task-related issues. While the current study aims to uncover the different concerns that teachers have, as well as how gender, teaching experience, and place of employment affect those concerns, it also seeks to understand how those concerns relate to one another. The sample for the study consisted of 37 teachers who attended the induction programme for Hindi PGTs working in Navodaya Vidyalayas from all over India. The 20-item checklist utilized in the survey approach is used to compile the teachers’ concerns. The correlation test and the chi-Square test are statistical tests used for data analysis. Learning, achievement, curriculum, classroom management, and students' needs, motivation, and behaviour are the identified components of teachers' concerns. The study's findings showed that female teachers indicated more concern than their male counterparts, and that teachers' concerns were unaffected by their teaching background or their State of employment. Results indicated a significant positive association between classroom management and students' needs, motivation, and behaviour. This has the connotation that, regardless of the curriculum, a student's progress is determined by classroom management, which considers their needs, engagement, and efforts to play a part in the growth of the country. The study concludes that teachers are responsive to the attainment of the educational objectives they have established for themselves as teachers.
ПОШИРЕНІСТЬ ГЕРПЕСВІРУСНИХ ІНФЕКЦІЙ СЕРЕД ПАЦІЄНТІВ З ПОСТТРАВМАТИЧНИМИ СТРЕСОВИМИ РОЗЛАДАМИ: ДАНІ ПІЛОТНОГО ПРОЄКТУ
Authors: Зубченко Світлана Олександрівна , Кріль Ірина Йосифівна , Надіжко Олена Миколаївна , Чопяк Валентина Володимирівна
Published: January 2023

Посттравматичний стресовий розлад (ПТРС) розвивається у 20-30% постраждалих після стресу осіб. Відбувається дисрегуляція адаптивних систем організму у відповідь на стрес, включаючи гіперреактивність симпатичної нервової системи та зниження активності глюкокортикоїдів. В етіології ПТСР розглядають також потенціал імунозалежного запалення, на тлі якого ймовірна реактивація герпесвірусних інфекцій. Формується порочне коло, асоційоване з хронічними стресовими розладами та імунозалежним запаленням з реактивацією герпесвірусів.
З метою дослідження поширеності реактивованих герпесвірусів у пацієнтів з ПТСР та аналізу їх клініко-лабораторних особливостей, відібрано 36 осіб.
Визначено, що у пацієнтів групи дослідження більшою мірою спостерігались емоційні розлади: тривожні думки – у 83,3% осіб, симптоми уникнення – у 72,2%, труднощі із засинанням – у 69,4% та інші. Поширеність герпесвірусів в активній фазі серед пацієнтів з ПТСР склала 78,1%. Найчастіше виявлено реактивацію вірусу герпесу людини6 типу (HHV-6) – у 46,9% і в ко-інфекції з вірусом Епштейна-Барр (EBV) у 28,1%. За результатами загальних лабораторних і біохімічних досліджень визначені незначні зміни гранулоцитів та агранулоцитів і підвищені показники CRP у 28,1% осіб.
Отримані результати вказують на високу поширеність, а відтак – ймовірність участі реактивованих герпесвірусів у патогенезі формування ПТСР. Розуміння складних взаємодій між функціонуванням різних ланок імунної системи за умов ПТСР на тлі реактивованих герпесвірусів дозволить переглянути тактику ведення таких пацієнтівзі включенням імуномодулюючої противірусної терапії.
CONGENITAL IMMUNODEFICIENCY DISORDERS IN THE PEDIATRIC PRACTICE
Authors: Drobova Nadiia , Lupaltsova Olga , Servetnyk Anzhela
Published: January 2023

Introduction. Congenital immunodeficiency disorders are genetic pathology that affect the immune system function and is important problem of modern medicine.

Material and methods. This dates are performed the clinical case of the child with congenital complement deficiency.

Results. Patient was diagnosed with allergic skin symptoms (atopic dermatitis, eczema), persistent bacterial infections of the upper and lower respiratory tract, late teething, diarrhea, chronic diseases of the gastrointestinal tract. That signs were manifestations of immunodeficiency states. During clinical and paraclinical examination the following data was detected in immunological blood test: decreased levels of CD3+-lymphocytes, CD3+CD8+-cytotoxic lymphocytes, CD19 +-lymphocytes. Gene panel of boy identifies one pathogenic variant in С8B (c. 1282C>T (p.Arg428*)), heterozygous, one pathogenic variant in C3 (c.2402C>T (p.Thr801Met)), heterozygous, which is associated with autosomal recessive and dominant. Uncertain significance variants were detected. Genetic signs in family members were also detected.

Conclusion. Genetic testing for identifying of congenital defects is very important in primary immunodeficiency diagnostic process.
A RETROSPECTIVE ANALYSIS OF THE USE OF POSSIBLE DRUGS FOR THE PREVENTION AND TREATMENT OF COVID-19
Authors: Kurchenko Andrii , Mankivska Olha , Kurchenko Kostiantyn , Fedoruk Halyna
Published: January 2023

As the SARS-CoV-2 pandemic takes its toll, the urgent search for effective preventive and therapeutic drugs is rapidly accelerating. Currently, there are no proven effective methods of treating COVID-19. Most antiviral drugs have only in vitro data. Solidarity clinical trials, in which not only the search for new drugs for the treatment of COVID-19 is carried out, but also the mass screening of existing drugs (mainly antivirals) that already have permission for use for treatment or for clinical trials. However, despite the great importance of a therapeutic strategy against the disease, the main way to prevent the spread of the virus is to develop an effective and safe prophylaxis.
ЕФЕКТИВНІСТЬ КОМБІНОВАНОЇ ІМУНОТЕРАПІЇ ПРОПЕСОМ ТА ІНФЛАМАФЕРТИНОМ ПРИ ВИБІРКОВОМУ ДЕФІЦИТІ NK- І NKT-КЛІТИН У ДІТЕЙ З РОЗЛАДАМИ СПЕКТРУ АУТИЗМУ, АСОЦІЙОВАНИМИ З ГЕНЕТИЧНИМ ДЕФІЦИТОМ ФОЛАТНОГО ЦИКЛУ
Authors: Мальцев Дмитро , Стефанишин Володимир
Published: January 2023

Вступ. Результати попередніх невеликих клінічних досліджень вказують на потенційну користь від комбінованої імунотерапії Пропесом та Інфламафертином для компенсації дефіциту NK- і NKT-клітин, зумовленого генетичним дефіцитом фолатного циклу, у дітей з розладами спектру аутизму.

Мета: вивчити ефективність комбінованої імунотерапії Пропесом та Інфламафертином при дефіциті NK- і NKT-клітин у дітей з розладами спектру аутизму, асоційованими з генетичним дефіцитом фолатного циклу.

Матеріали і методи. В даному одноцентровому проспективному контрольованому нерандомізованому клінічному дослідженні брали участь 96 дітей віком від 2 до 10 років, що страждали на розлади спектру аутизму, асоційовані з генетичним дефіцитом фолатного циклу (досліджувана група, ДГ). Діти ДГ отримували Пропес в дозі 2 мл в/м через день на ніч протягом 3 місяців підряд (45 ін’єкцій) та Інфламафертин в дозі 2 мл в/м через день на ніч протягом 3 місяців підряд, чергуючи з Пропесом (45 ін’єкцій). Контрольну групу (КГ) склали 32 дітей аналогічного вікового і гендерного розподілу, що страждали на розлади спектру аутизму, асоційовані з генетичним дефіцитом фолатного циклу, однак не отримували імунотерапії.

Результати та їх обговорення. Кількість NK-клітин досягла нижньої межі норми у 39 із 53 пацієнтів (74% випадків) з вихідним дефіцитом цих лімфоцитів, а середня кількість NK-клітин в крові в ДГ збільшилася майже вдвічі протягом 3-місячного курсу імунотерапії (р<0,05; Z0,05; Z>Z0,05). Кількість NKT-клітин нормалізувалася у 78 із 87 пацієнтів (89% випадків) з вихідним дефіцитом цих клітин, а середня кількість NKT-клітин в крові в ДГ зросла під час курсу імунотерапії наполовину (р<0,05; Z<Z0,05) і продовжувала зростати протягом 2-х наступних місяців після відміни імунотропних препаратів (р<0,05; Z<Z0,05). Відзначалася спряженість між проведенням імунотерапії та нормалізацією кількості NK- (χ2=18,016; OR=13,929; 95%CI=3,498-55,468) і NKT-клітин (χ2=60,65; OR=46,800; 95%CI=14,415-151,937) в крові з сильним зв’язком між цими процесами (критерій φ=0,504 i 0,715 відповідно; С=0,450 і 0,581 відповідно).

Висновки. Комбінована імунотерапія за допомогою Пропесу та Інфламафертину – ефективна стратегія лікування імунодефіциту, зумовленого генетичним дефіцитом фолатного циклу, у дітей з розладами спектру аутизму.
ГОСТРЕ ПОШКОДЖЕННЯ НИРОК, СПРОВОКОВАНЕ ТРИВАЛИМ МАРАФОНОМ БІГУНА
Authors: Мойсеєнко Валентина , Буржинська Інна , Никула Андрій
Published: January 2023

Вступ. Біговий марафон – це спортивні змагання з бігу на дистанцію, що становить 42 км 195 м. Як на тривалий біг реагують нирки? М’язова і сечовидільна системи тісно пов’язані між собою як на фізіологічному, так і на функціональному рівні. При виконанні фізичної роботи у людини змінюється кількісний і якісний склад сечі. В ній з’являються речовини, які зазвичай були відсутні, або були присутні в сечі в незначних кількостях. Як правило, помірні фізичні навантаження сприяють збільшенню діурезу, в той час як вправи великої інтенсивності приводять до помітного зниження діурезу. Після участі в марафоні необхідно регулярно здавати сечу, не допускати надмірних навантажень на спину і дотримуватися збалансованого харчування.

Мета. Описати клінічний випадок несвоєчасної діагностики гострої ниркової недостатності, яка виникла після марафону бігуна, та перелому нижньої лівої лобкової кістки після недоречних мануальних процедур, проведених з метою усунення болю в попереку, який виник також після марафону, проаналізувати динаміку лабораторно-інструментальних показників.

Матеріали і методи. Огляд сучасних та зарубіжних джерел, аналіз та обговорення конкретного клінічного випадку; методики – опис, аналіз, реферування.

Результати та їх обговорення. Наведено і проаналізовано конкретний клінічний випадок виникнення гострого пошкодження нирок, гострої ренальної ниркової недостатності, нефритичного синдрому (стадія оліго-анурії) після бігового марафону, а також перелому нижньої лівої лобкової кістки після недоречних мануальних процедур, проведених з метою усунення болю в попереку, який виник також після марафону.

Висновки. При достатньому рівні прихильності до лікування, можливим є значне покращення стану пацієнтки після того, як надлишок креатиніну, білку та сечовини в організмі буде усунуто. Що в свою чергу сприятиме нормалізації діурезу та загального стану пацієнтки. При корекції харчування, раціоналізації дієти та дотримання рекомендацій лікаря стосовно лікування, можливим є переведення ГНН в період одужання. Тимчасове часткове обмеження працездатності на період лікування у стаціонарі та реабілітації. Дотримання рекомендацій лікаря-травматолога.
Hubungan Infeksi Soil-Transmitted Helminths (STH) Dengan Kejadian Stunting pada Balita di Kabupaten Bulukumba
Authors: A.R.Pratiwi Hasanuddin  , Asdinar
Published: January 2023

Malnutrisi dan infeksi kecacingan bertalian satu dengan yang lain, malnutrisi dapat menyebabkan cacingan dan sebaliknya cacingan dapat menyebabkan malnutrisi. Tujuan penelitian ini untuk mengetahui hubungan infeksi kecacingan dengan stunting pada balita di Kabupaten Bulukumba. Metode penelitian Menggunakan rancangan cross-sectional dengan teknik consecutive sampling. Balita berumur 24-59 bulan sebanyak 20 orang yang telah masuk kedalam kategori stunting. Pengumpulan data pada bulan Desember 2019 – Februari 2020 di Kecamatan Ujung Bulu dan Kecamatan Gantarang di Kabupaten Bulukumba. Orang tua subjek di wawancarai menggunakan panduan kuesioner. Sampel tinja dikumpulkan dan diamati menggunakan metode natif (langsung). Hasil penelitian menunjukkan bahwa dari 666 balita di Kecamatan Ujung Bulu dan Kecamatan Gantarang, hanya 20 balita yang memenuhi syarat penelitian dan  telah dikategorikan stunting. Infeksi kecacingan memiliki persentase sebesar 20% (4 balita) dengan intensitas infeksi paling banyak adalah cacing Ascaris lumbricoides 15%. Hasil analisis hubungan antara infeksi STH dengan status gizi berdasarkan TB/U menunjukkan nilai p>0.05. Kesimpulan bahwa tidak terdapat hubungan antara infeksi STH dengan kejadian stunting pada balita yang ada di Kabupaten Bulukumba.
Uji Efektivitas Antibakteri Ekstrak Daun Serai Terhadap Pertumbuhan Streptococcus Mutans
Authors: Andayani Lilis , Ridwan Asriyani , Rahmat Aryandi  , Subakhir Salnus
Published: January 2023

Daun sereh memiliki kandungan minyak atsiri yang mana minyak atsiri ini diketahui juga mampu sebagai antibakteri. Tujuan dari penelitian ini adalah Untuk mengetahui efektivitas ekstrak daun sereh terhadap pertumbuhan bakteri Streptococcus mutans. Penelitian ini merupakan penelitian  True experiment design dengan rancangan penelitian posttest only control group design . Data uji secara statisik menggunakan uji One Way Anova.Kelompok perlakuan pada penelitian ini terdiri atas kontrol positif siproflofaksin, kontrol negatif aquades steril dan kelompok konsentrasi 20%, 40%, 60%, 80%, dan 100% dengan pengulan 3 kali untuk masingmasingkelompok. Ekstrak daun sereh konsentrasi 20%,60%, dan 80% efektif digunakan dalam menghambat pertumbuhan bakteri streptococcus mutans dan ekstrak daun sereh konsentrasi 40%,dan 100% tidak efektif digunakan dalam menghambat pertumbuhan bakteri streptococcus mutans. Terdapat 3 konsentrasi ekstrak daun sereh dengan 3 kali pengulangan yang mampu menghambat pertumbuhan bakteri streptococcus mutans yakni konsentrasi 20%,60% dan 80% serta terdapat 2 konsentrasi yang tidak efektif digunakan dalam menghambat pertumbuhan bakteri streptococcus mutans yakni konsentrasi 40% dan 100%.
Identifikasi Kejadian Anemia pada Komunitas Gamers Rewa Lingkungan Caile Kelurahan Sangiasseri Kabupaten Sinjai
Authors: Nurfainul  , Asdinar  , Dzikra Arwie
Published: January 2023

Tingginya angka pengguna internet di indonesia, salah satu produknya yang berkembang sangat pesat saat ini adalah game online. Secara tidak langsung game online ini dapat memberikan dampak negatif karena banyaknya waktu yang dihabiskan untuk bermain dari pada istirahat. Oleh karena itu perlu dilakukan pemeriksaan kadar hemoglobin pada gamer. Individu gamer tersebut mempunyai waktu tidur yang kurang pada malam hari dan pola tidur yang tidak teratur. Kurang nya waktu tidur tersebut bisa menyebabkan penurunan kadar hemoglobin pada tubuh.Tujuan penelitian ini adalah untuk mengidentifikasi kejadian anemia pada komunitas Gamers Rewa, Lingkungan Caile, Kelurahan Sangiasseri. Jenis penelitian ini adalah penelitian kuantitatif metode deskriptif dengan mengunakan pendekatan survey observasi, dengan jumlah populasi sebanyak 32 orang,dan sampel dalam penelitian ini sebanyak 22 orang. Hasil penelitian menunjukkan bahwa anemia ringan terjadi pada 11 responden, sedangkan anemia sedang dialami oleh 3 responden, dan 8 responden memilki kadar hb normal. Kesimpulan dari penelitian ini adalah terdapat kejadian anemia pada komunitas Gamers Rewa.
Studi Hasil Pemeriksaan Eritrosit Pada Sediaan Apusan Darah Tepi Menggunakan Zat Pewarna Alami Dari Ekstrak Uwi Ungu (Discorea alata)
Authors: Nirmala Dewi  , Rahmat Aryandi  , Fitriani
Published: January 2023

Sel darah merah adalah salah satu sel darah dengan jumlah paling banyak dibandingkan dengan sel darah lainnya.Sel darah merah berbentuk cakram bikonfaf dengan struktur sel yang tidak lengkap dengan ketebalan1,5-2,5 mikrom.fungsi eritrosit sebagai pembawah oksigen dari paru-paru ke seluruh jaringan .Didalam eritrosit atau sel darah merah terdapat suatu senyawa protein yaknik hemaglobin (Hb) dimana senyawa ini dapat mengikat zat besi sehingga dapat memberi warna merah pada dalam darah.Selain pewarnaan giemsa, pada penelitian ini juga akan digunakan ekstrak uwi ungu sebagai pewarnaan. Karna ekstran uwi ungu mengandung antosianin . Pemanfaatan ekkstrak uwi ungu yang dijadikan sebagai pewarnaan merupakan salah satu upaya pemanfaatan untuk dijadikan pewarna aternatif pengganti giemsa.Tujuan dalam pemenitian ini yaitu Diketahui kualitas eritrosit menggunakan zat pewarna alami dari ekstrak uwi ungu sebagai pengganti giemsa dengan konsetrasi 20%,40%,60%,80%,100%.Hasil dari penelitian ini hanya konsetrasi 100% yang bisa dilihat eritrositnya dengan bentuk samar samar dengan warna pucat dibanding dengan konsetrasi  lain yang tidak terlihat jelas dan dari segi kualitas masih lebih bagus warna giemsa dibanding ekstrak uwi ungu.

Kata Kunci: Erotrosit.Apusan Darah tepi Ekstrak Antosiani Uwi Ungu (Discorea alata)
Simulation of Chaotic Operation οf A Damped Driven Pendulum Using Python
Authors: Jani Joan
Published: January 2023

In this paper, we are presenting a new pedagogical method for the introduction of the study of nonlinear systems. Our approach is based on the use of open-source software which is publicly available. In response to this motivation, we are using the Python programming language which offers a holistic approach to scientific research. We will present the analysis of the pendulum motion under the influence of an external force. The differential equation governing the system will be presented and solved using numerical methods. Moreover, the phase diagram of the system will be presented for various system parameters. We will describe the transition to a chaotic operation and the key factors of this procedure. The chaotic behaviour is verified by calculating the maximum Lyapunov exponent. This pedagogical approach emerging is based on the physical properties of the system and not on the numerical methods used so that the student can understand the dynamics of the system more comprehensively.
Family Parents’ Perspective of Different Social-Economical Statuses about the Online and Offline Classes during the COVID-19 Pandemic
Authors: Ortiz Carlos Granados , Aristizabal Sweney Giraldo , Escorcia Ivan Padilla , Rojas-Sandoval Yesika , Movilla José Gregorio Solórzano , Pacheco Salomón David Consuegra , Fontalvo Yolima Rocha
Published: January 2023

This research work aimed to characterize the perception of parents of educational institutions of various socioeconomic strata of Barranquilla-Colombia about the teaching of classes in the synchronous and asynchronous mode in times of Covid-19. With a qualitative approach and an interpretative-hermeneutical design, 6 parents were chosen and an unstructured interview was applied in which aspects such as connectivity, strategies used by teachers and interaction with them during the pandemic were addressed. The main finding was that parents who are enrolled in low-income institutions agree that they do not have the guarantees for their children to receive a quality education under the modality at home; For their part, the parents who have their children enrolled in a high socioeconomic level assure that despite the fact that educational institutions have resources to teach the contents of the areas of knowledge, their attendants were demotivated by the new modality of teaching.
Design and Implementation of Painting and Replacement Automation Robot System in Spindle Line for Smart Manufacturing
Authors: Kim Oungsub , Han Yohan , Jeong Jongpil
Published: January 2023

In the process of painting the surface of injection products, the spray trajectory and speed are very important and have a very important effect on productivity and quality. However, since it is very difficult to standardize and quantify each product, it was difficult to apply automation to the painting process, so there were many cases where people directly operated it. Recently, with the development of robot technology, many manufacturing processes performed by humans are being replaced. To automate painting in the spindle line of the painting process, we design Painting and Replacement Automation Robot System in Spindle Line. By implementing it in an actual production line, we have greatly improved productivity and reduced paint replacement time.
Is Reforming the Corporate Governance System Necessary?
Authors: Foeh John E. H. J. , Permatasari Diah Ayu , Sinaga Jhonni , Manurung Adler Haymans
Published: January 2023

Due to lax corporate governance practices over the past few decades, fraud has both increased in severity and frequency. The goal of this research is to improve current governance systems to help businesses deal with issues in the global corporate environment. For a public company to succeed, it needs a solid corporate governance system. It is critical to establish appropriate transparency guidelines and procedures. Reforms are required to address existing issues and improve global corporate governance in the following ways: a. The audit committee must monitor and enforce financial and disciplinary matters; b. The board structure must be balanced; c. Continuous disclosure must be prioritized; d. CFOs and CEOs must be held explicitly accountable for their actions; e. The selective mechanism must be completed; and f. The auditor's role must be changed from that of a watchdog to that of a whistleblower.
Real-world clinical practice in health technology assessment: state of the art for 2022
Authors: Kurylev A. A. , Zhuravkov A. A. , Kolbin A. S.
Published: January 2023

The real-world data are used in drug authorization procedures, comparative efficacy and safety research, to make changes in the Summary of Product Characteristics, clinical recommendations. One more aspect where RWD/RWE can be used is the health technology assessment. Although there is a clear need for high-quality recommendations regarding RWE studies, published today documents do not contain clear instructions.
Why Were They Not Radicalized? Young Members of the Muslim Brotherhood in the Aftermath of Egypt's 2013 Military Coup
Authors: Abdelgawad Doha
Published: January 2023

While many young members of Egypt's Muslim Brotherhood became politically disengaged in the wake of the 2013 military coup, others resorted to violence. Drawing upon fieldwork conducted in 2016/17, this article investigates the forces of radicalization among younger Brotherhood members
after the coup. Rather than there being a positive correlation between repression and radicalization, I argue that the majority of rank-and-file movement members remained inclined against radicalism due to the effects of state repression, organizational schism, and transformative personal
experiences.
Yemen: South Yemen's Independence Struggle: Generations of Resistance, by Anne-Linda Amira Augustin (book review)
Authors: Brandt Marieke
Published: January 2023

South Yemen's Independence Struggle: Generations of Resistance, by AnneLinda Amira Augustin. Cairo: American University in Cairo Press, 2021. £50.
Pengaruh Emotional Quotient Terhadap Strategi Coping Stress Generasi Milenial Dalam Bermedia Sosial
Authors: Syafindra Yaumil , Samputra Palupi Lindiasari
Published: January 2023

The purpose of this study is to find out how emotional quotient influences stress coping strategies in the millennial generation on social media. The method used is synthetic review using journal references for the last ten years. The results of this study indicate that 90% has a positive effect and 10% shows negative results on emotional quotient in coping stress strategies on social media. The conclusion is that there is a positive relationship between emotional quotient and stress coping strategies in the millennial generation which are influenced by different aspects according to what Goleman put forward. Thus, a person's high level of emotional quotient will also affect high coping strategies. The advice given to the millennial generation is expected to be able to manage emotions well and be able to use stress coping strategies in an effort to reduce negative emotions
Wanprestasi Terhadap Akta Perjanjian Pengikatan Jual Beli (PPJB) Rumah Susun yang Dibuat oleh Notaris
Authors: Palar Vicky Caesar Elang , Mekka Mohamad Fajri
Published: January 2023

Property sale and purchase transactions such as flats are transactions with large nominal values. The related parties must make a binding sale and purchase agreement as a means of legal protection for both parties in the event of a default against PPJB made by a notary so that the letter becomes official and safe. This study aims to determine the causal factors, and the legal protection of default of the sale and purchase binding deed (PPJB) of the apartment made by a notary. In addition, PPJB is also a letter made by a notary and as legal protection for consumers and is officially made by a notary.