bluuebunny/crossref_metadata_2025 huggingface dataset:
Public knowledge and attitude toward lumbar puncture among adults in Riyadh, Saudi Arabia: A cross-sectional study
Authors: Aldayel Abdulrahman Yousef , Alharbi Muteb Mousa , Almasri Mohammed Saud , Alkhonezan Saleh Mansoor
Published: August 2019

Objective:

The aim of this study is to evaluate knowledge of and attitudes toward the lumbar puncture procedure among adults in Riyadh region, Saudi Arabia, 2018.

Methods:

This study used a quantitative cross-sectional evaluation of the responses of adults aged ⩾18 years from the Saudi Telecom Company database in the Riyadh region of Saudi Arabia to an online survey between October and December 2018. The questionnaire included questions on knowledge, attitudes, and demography. The questionnaire was pretested and validated (Cronbach’s alpha = 0.701).

Results:

Of 1500 questionnaires, 1223 (81.5%) were returned and included in the analysis. In the study, 57.7% of the participants were aged 18–25 years, and 58.5% of the participants were females. Only 235 (19.2%) participants had an accepted knowledge level of lumbar puncture. The attitudes of the majority of the participants ( n = 1151, 94%) to lumbar puncture were acceptable. A multivariate logistic regression test revealed a significant association between an acceptable knowledge level and acceptable attitude level (odds ratio = 2.30, 95% confidence interval = 1.06–5.66). A significant association was also found with ages over 46 years old (odds ratio = 12.99, 95% confidence interval = 4.45–37.9). The attitudes level toward lumbar puncture had a significant negative association among the participants who had a fear of injections in the lumbar region (odds ratio = 0.46, 95% confidence interval = 0.3–0.68).

Conclusion:

There is a lack of appropriate knowledge of the lumbar puncture procedure among the public which predict an unacceptable attitude toward lumbar puncture. Improvements in public education could improve public awareness of the clinical importance/value and complications of lumbar puncture.
HIV-1-derived exosomal microRNAs miR88 and miR99 promote the release of cytokines from human alveolar macrophages by binding to TLR8
Authors: Zhao Hui , Sun Zhenming , Li Lifang , Zhi Shuyin , Zhao Yiru , Zhang Zhihua , Wang Runyu , Li Jianqiang
Published: August 2019

The human monocytic cell line U937 and human alveolar macrophages were used as in vitro models to explore the role of miR88 and miR99 in the chronic abnormal activation of the body caused by human immunodeficiency virus (HIV). The functions and underlying mechanisms of miR88 and miR99 were studied by real-time quantitative polymerase chain reaction, transwell, and chromatin immunoprecipitation (ChIP) assays. HIV-1-infected cells released miR88 and miR99 into the extracellular space through exosomes, and miR88 and miR99 promoted the release of tumor necrosis factor alpha (TNFα), interleukin (IL)-6, and IL-12 by activating inflammatory factors, such as TLR8, on the surface of macrophages. HIV-derived microRNAs miR88 and miR99 performed these functions by binding to TLR8 and stimulating the release of pro-inflammatory factors from macrophages, such as TNFα, IL-6, and IL-12; these factors may be involved in chronic abnormal immune activation induced by HIV infection.
Grandparenting in Urban Bangalore, India: Support and Involvement From the Standpoint of Young Adult University Students
Authors: Gray Peter B. , Longkumer Watinaro , Panda Santona , Rangaswamy Madhavi
Published: August 2019

A variety of caregivers, including grandparents, help raise children. Among grandparents, most Western samples evidence a matrilateral (i.e., mother’s kin) bias in caregiving, and many studies show more positive impacts and stronger relationships with grandmothers than grandfathers. The aim of the present study is to test competing hypotheses about a potential laterality bias and explore contrasts between grandmothers and grandfathers in a sample of urban young adult university students in Bangalore, India. A sample of 377 (252 women) relatively mobile and high socioeconomic status individuals 17 to 25 years of age completed a survey consisting of sociodemographic and grandparenting questions. Results reveal generally little evidence of either a patrilateral or matrilateral bias, though findings varied for some outcomes. As illustrations, there were no differences in residential proximity or the most recent time when a participant saw matrilateral or patrilateral grandparents, whereas maternal grandmothers were more approving of one’s choice of a life partner than were paternal grandmothers. In inductively coded responses to an open-ended item about the roles of grandparents, maternal grandmothers were more often identified as “guides” and less often deemed “non-significant” than paternal grandmothers, while paternal grandfathers were less often viewed as guardians and more often noted for their influence compared with maternal grandparents. Findings also revealed differences between grandmothers and grandfathers, such as grandmothers playing more prominent roles in community and religious festivals. Findings are interpreted within changing residential, work, education, and family dynamics in urban India as well as a primary importance on parents relative to grandparents.
The modified anterolateral approach to the humerus
Authors: Chang Angela Christine , Ha Ngoc Buu , Sagar Christopher , Bain Gregory Ian , Leonello Domenic Thomas
Published: August 2019

Introduction:

The anterior and anterolateral approaches to the humerus describe splitting brachialis longitudinally, assuming its fibres run parallel to the shaft. Recent improvements in the understanding of brachialis anatomy however have demonstrated it has two distinct heads, with the bulk of its fibres running oblique relative to the humerus. Attempting to split brachialis longitudinally to the extent required for plate osteosynthesis invariably leads to transection of a significant number of muscle fibres. The authors present a less muscle destructive modification to the anterolateral approach (ALA) based on a bicipital brachialis muscle.

Method:

In order to preserve brachialis muscle fibres, the modified ALA elevates the superficial head from the underlying humerus and longitudinally splits the deep head to allow a fixation device to be tunnelled. Case notes of patients with a humeral shaft fracture fixed via the modified ALA were retrospectively reviewed.

Results:

Ninteen humeral shaft fractures were fixed via the modified ALA. No post-operative nerve palsies were reported. Of the 19 patients, 14 (73.7%) received clinical and radiological follow-up. All reported being satisfied with their outcome. One developed a superficial wound infection and one (previous diagnosis of spondyloepiphyseal dysplasia tarda) developed a non-union requiring revision surgery. Of the five patients lost to follow-up, two died, and three reported no ongoing orthopaedic issues via telephone.

Conclusions:

Improved anatomical understanding of brachialis has resulted in the described modification to the ALA which is less muscle destructive and follows a truer inter-nervous plane. This small series demonstrates satisfactory outcomes using this approach.
The Effect of Instructors’ Immediate Behaviors and Clarity on Student Writing Apprehension
Authors: Kelly Stephanie , Gaytan Jorge
Published: August 2019

The demand for writing skills is becoming increasingly prevalent within the U.S. job market. Yet, the biggest barrier to developing successful writing skills, writing apprehension, has received very little attention from scholars in the past 30 years. The present study sought to identify the influence of instructional communicative behaviors on business students’ writing apprehension. Specifically, the study tested a model in which instructors’ immediate behaviors and clarity indirectly influenced students’ writing apprehension through the mediation of perceived immediacy. The data were consistent with the hypothesized model.
First-Year Outcomes of Critical Congenital Heart Disease Screening in Maryland
Authors: Badawi Deborah , Watson Johnna , Maschke Steven , Reid Lawrence
Published: August 2019

Objectives. Newborn screening for critical congenital heart disease (CCHD) was added to the Recommended Uniform Screening Panel in 2011, and states have been gradually adding pulse oximetry as point-of-care screening to panels. Few data are available on the effectiveness of pulse oximetry as a mandated screening. This study describes outcomes of the first year of screening in Maryland. Methods. A web-based data collection tool for screening results and outcomes, eScreener Plus, was utilized. Data collected from the start of screening from September 1, 2012, to December 31, 2013, were analyzed. Well-baby nursery data were evaluated separately from neonatal intensive care unit (NICU) data to determine whether setting influenced effectiveness. Results. In the first 15 months of newborn screening for CCHD in Maryland, 4 asymptomatic infants were diagnosed with a critical cardiac condition by newborn screening. Eleven infants passed but were later identified with a primary or secondary target condition. Seventy-one percent of infants with CCHD were identified prenatally or by clinical signs and symptoms. Pulse oximetry screening for CCHD had a specificity of more than 99% in both the well-baby nursery and the NICU. Sensitivity in the well-baby nursery was 10% and 60% in the NICU. Conclusion. Further investigation and interpretation of specific protocols that were used and outcomes of screening is needed for continued refinement of the well-baby algorithm and NICU protocol development. Pulse oximetry screening in newborns provides valuable clinical information, but many infants with CCHD are still not identified with current protocols.
Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease
Authors: Sabe Ramy , Vatsayan Anant , Mahran Amr , Khalili Ali S. , Ahuja Sanjay , Sferra Thomas J.
Published: August 2019

Background. Anemia is common in inflammatory bowel disease (IBD). Oral iron is widely used but efficacy can be reduced by poor compliance and insufficient absorption. Intravenous iron is safe and effective in adults but is not well studied in children. Purpose. To assess safety and efficacy of intravenous iron sucrose (IVIS) in children with IBD. Methods. We reviewed medical records of IBD patients <22 years of age who received IVIS at our institution between 2009 and 2014. Anemia was defined as hemoglobin (Hgb) level below normal for age and gender and iron-deficiency anemia as serum iron studies and red cell mean corpuscular volume below normal ranges. Each IVIS infusion was evaluated for safety. Efficacy was defined as ≥2 g/dL increase in Hgb ≤12 weeks from IVIS initiation. Results. We identified 88 patients (Crohn’s disease, n = 52; ulcerative colitis, n = 33; IBD-unclassified, n = 3) who underwent 329 IVIS infusions over 121 courses. No patient developed anaphylaxis. Six patients developed minor adverse reactions. Of the 121 IVIS courses, 80 were included in the efficacy evaluation. There was a significant rise in Hgb (mean 9.1 ±1.4 to 11.9 ± 1.8 g/dL; P < .0001, paired t test). Overall, 58.7% (47/80 courses) resulted in goal Hgb increase. Conclusions. IVIS is safe and effective in treating iron-deficiency anemia in pediatric IBD. There were only minor adverse events, and the observed rise in Hgb was clinically significant, with the majority achieving goal Hgb.
“Daddies,” “Cougars,” and Their Partners Past Midlife: Gender Attitudes and Relationship and Sexual Well-Being among Older Adults in Age-Heterogenous Partnerships
Authors: Silva Tony
Published: August 2019

Discussion of “daddies” has exploded in popular discourse, yet there is little sociological research on age-heterogenous partnerships. This paper uses data from the 2013 Midlife in the United States survey and the 2015–2016 National Social Life, Health, and Aging Project to examine age-heterogenous partnerships at older ages (63 was the approximate average age of each sample). On most measures of life satisfaction and relationship well-being, individuals in age-heterogenous partnerships—regardless of age or gender—were not very different from their counterparts in age-homogenous relationships. Some differences did emerge, however, especially related to sexual well-being. Women partnered to older men had less sex and more issues related to sexual satisfaction than their counterparts in age-homogenous relationships. Latent class analyses suggest that these differences were driven by around 40 percent of younger women partnered to older men, a minority of whom were deeply dissatisfied. This research helps address the underrepresentation of sexuality research at older ages and the sociological research gap about age-heterogenous partnerships.
The Intersections of Identities and Justice-Oriented Efforts of Urban Literacy Educators
Authors: Skerrett Allison , Williamson Thea , Warrington Amber , Salmerón Cori , Brady Randi Beth
Published: August 2019

This article draws from an ongoing longitudinal qualitative inquiry into the preparation and development of social justice–oriented urban English teachers. It examines the cases of three graduates of an urban education–focused teacher preparation program who claim different intersectional identities and have completed their fourth year as urban educators. The article explores two research questions. First, how do these teachers understand and enact critical education practices within their curriculum and instruction, socially situated relationships, and institutional structures? Second, how do they experience and understand their sociocultural identities as contributors to their practices as critical educators and the associated outcomes? Two findings are discussed. First, the teachers felt greatest agency and success within their classrooms (in comparison to other institutional spaces) to enact social justice–oriented curricula, instruction, and other educational practices, using relationship-building with students as the foundation of their work. Second, identity constructs of gender, age, and race significantly mediated the teachers’ relationship-building efforts with colleagues and administrators, the teachers’ feelings of agency, and their activities and outcomes related to justice-oriented change at institutional levels beyond the classroom. This study contributes a rare longitudinal example of how in-service critical educators’ sociocultural identities impact their literacy pedagogies and institutional efforts to advance educational justice.
Entrepreneurship Education's Impact on Entrepreneurial Intention Using the Theory of Planned Behavior: Evidence From Chinese Vocational College Students
Authors: Lavelle Brian A.
Published: August 2019

This study is the first to examine the impact of entrepreneurship education (EE) on entrepreneurial intention (EI) among vocational college students in China. Using the Theory of Planned Behavior and the EI Questionnaire the study investigates the relationships between EI, its antecedents and EE. The data were collected by surveying 383 vocational college students in Wuxi, Jiangsu, in the People's Republic of China. The researcher used Least-Squares Regression modeling to find significant positive relationships between personal attitude, perceived behavioral control, and EE with EI. Mediation analysis found personal attitude to partially mediate the EE–EI relationship. The results suggest EE is effective in stimulating EI in China. This study provides implications to policy-makers, vocational institutions, and scholars given the current state of China's economy, recent government policies, and the ongoing debate surrounding the EE–EI relationship.
Nonmyeloablative TLI-ATG conditioning for allogeneic transplantation: mature follow-up from a large single-center cohort
Authors: Spinner Michael A. , Kennedy Vanessa E. , Tamaresis John S. , Lavori Philip W. , Arai Sally , Johnston Laura J. , Meyer Everett H. , Miklos David B. , Muffly Lori S. , Negrin Robert S. , Rezvani Andrew R. , Shizuru Judith A. , Weng Wen-Kai , Hoppe Richard T. , Strober Samuel , Lowsky Robert
Published: August 2019

Nonmyeloablative total lymphoid irradiation and antithymocyte globulin (TLI-ATG) conditioning is protective against graft-versus-host disease (GVHD), while retaining graft-versus-tumor activity across various hematologic malignancies. We report our comprehensive experience using TLI-ATG conditioning in 612 patients with hematologic malignancies who underwent allogeneic transplantation at Stanford University from 2001 to 2016. All patients received granulocyte colony-stimulating factor–mobilized peripheral blood grafts and cyclosporine and mycophenolate mofetil for GVHD prophylaxis. The median age was 60 years (range, 21-78), with a median follow-up of 6.0 years (range, 1.0-16.4). Common diagnoses included acute myeloid leukemia (AML; n = 193), myelodysplastic syndrome (MDS; n = 94), chronic lymphocytic leukemia (CLL; n = 80), non-Hodgkin lymphoma (NHL; n = 175), and Hodgkin lymphoma (HL; n = 35). Thirty-four percent of patients had a comorbidity index ≥3, 30% had a high to very high disease risk index, and 56% received unrelated donor grafts, including 15% with HLA-mismatched donors. Ninety-eight percent underwent transplant in the outpatient setting, and 57% were never hospitalized from days 0 through 100. The 1-year rates of nonrelapse mortality (NRM), grade II-IV acute GVHD, and extensive chronic GVHD were 9%, 14%, and 22%, respectively. The 4-year estimates for overall and progression-free survival were 42% and 32% for AML, 30% and 21% for MDS, 67% and 43% for CLL, 68% and 45% for NHL, and 78% and 49% for HL. Mixed chimerism correlated with the risk of relapse. TLI-ATG conditioning was well tolerated, with low rates of GVHD and NRM. Durable remissions were observed across hematologic malignancies, with particularly favorable outcomes for heavily pretreated lymphomas. Several efforts are underway to augment donor chimerism and reduce relapse rates while maintaining the favorable safety and tolerability profile of this regimen.
Normal peripheral blood neutrophil numbers accompanying ELANE whole gene deletion mutation
Authors: Horwitz Marshall S. , Laurino Mercy Y. , Keel Siobán B.
Published: August 2019

Key Points

The patient reported here, along with collective observations in the literature, suggest that ELANE deletion does not cause neutropenia. Potential therapeutic genome editing involving knockout of the mutant ELANE allele is therefore not expected to produce neutropenia.
Semiautomated seismic horizon interpretation using the encoder-decoder convolutional neural network
Authors: Wu Hao , Zhang Bo , Lin Tengfei , Cao Danping , Lou Yihuai
Published: August 2019

The seismic horizon is a critical input for the structure and stratigraphy modeling of reservoirs. It is extremely hard to automatically obtain an accurate horizon interpretation for seismic data in which the lateral continuity of reflections is interrupted by faults and unconformities. The process of seismic horizon interpretation can be viewed as segmenting the seismic traces into different parts and each part is a unique object. Thus, we have considered the horizon interpretation as an object detection problem. We use the encoder-decoder convolutional neural network (CNN) to detect the “objects” contained in the seismic traces. The boundary of the objects is regarded as the horizons. The training data are the seismic traces located on a user-defined coarse grid. We give a unique training label to the time window of seismic traces bounded by two manually picked horizons. To efficiently learn the waveform pattern that is bounded by two adjacent horizons, we use variable sizes for the convolution filters, which is different than current CNN-based image segmentation methods. Two field data examples demonstrate that our method is capable of producing accurate horizons across the fault surface and near the unconformity which is beyond the current capability of horizon picking method.
Identification and Confirmation of Potentially Actionable Germline Mutations in Tumor-Only Genomic Sequencing
Authors: Clark Dana Farengo , Maxwell Kara N. , Powers Jacquelyn , Lieberman David B. , Ebrahimzadeh Jessica , Long Jessica M. , McKenna Danielle , Shah Payal , Bradbury Angela , Morrissette Jennifer J.D. , Nathanson Katherine L. , Domchek Susan M.
Published: August 2019

PURPOSE

Tumor-only genomic profiling (TGP) is increasingly advocated for all patients with cancer given the possible therapeutic implications. It is critical to develop clinical algorithms to identify and address potentially actionable germline findings identified by TGP.

METHODS

A multidisciplinary team analyzed publicly available data for genes in which mutations are implicated in germline cancer susceptibility and established a pipeline to automate clinical referral for evaluation of TGP findings.

RESULTS

A total of 2,308 patients underwent TGP, with 81 patients (3.5%) identified by the automatic referral pipeline; 37 patients (1.6%) were referred outside the pipeline based on concerns by the molecular geneticist, pathologist, or oncologist regarding genotype-phenotype correlation. Thirty-one patients (38%) and 17 patients (46%) underwent germline testing from the automatic pipeline and other referrals, respectively, and of these patients, 23 (72%) and four (24%) had confirmed germline pathogenic variants (GPVs), respectively. The majority of confirmed GPVs were in automatic referral genes, with BRCA2 being most common (confirmed GPVs in 11 [85%] of 13 patients tested), followed by PALB2 (five [67%] of six patients), BRCA1 (two [40%] of five patients), MSH6 (two of three patients), and MLH1 (two of two patients). Forty-eight percent of confirmed GPVs were found in tumors known to be associated with germline mutations in the gene. Germline testing was not performed in 50 (62%) of 81 patients identified by automatic referral as a result of poor patient health or death (30%), lack of follow-up (30%), and patient refusal (30%).

CONCLUSION

Of patients undergoing TGP, 5% had somatic findings triggering referral, and implementation of an automatic referral pipeline based solely on gene versus other clinical or molecular features resulted in a 74% germline confirmation. However, only 41% of referred patients underwent germline testing. Systems-based approaches are needed to identify carriers of actionable germline cancer susceptibility mutations identified by TGP.
Heinrich Reichert (1949-2019)
Authors: Sen Sonia , VijayRaghavan K.
Published: August 2019

Heinrich Reichert, Professor Emeritus at the University of Basel, Switzerland, passed away on the 13th of June 2019 after a prolonged illness. Heinrich described himself as ‘a hedonist when it came to science’ because he said it gave him great pleasure. It was this quality that made working with Heinrich thrilling and deeply fulfilling. Heinrich's long and versatile career spanned the breadth of neuroscience – from development, to evolution and behaviour. In his passing we have lost not just an astute scientist, but also an impassioned educator and an adventurer of science.
Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair
Authors: Lastwika Kristin J. , Dunn Clarence A. , Solan Joell L. , Lampe Paul D.
Published: August 2019

The gap junction protein connexin 43 (Cx43) is a key player in wound healing, and inhibitors of Cx43, which speed epidermal wound healing, are currently in clinical trials. Here, we provide direct in vivo evidence that specific phosphorylation events on Cx43 change the physiological response during wound healing. Blocking phosphorylation, through mutation of serine residues in Cx43 at the protein kinase C (PKC) or casein kinase 1 (CK1) sites, significantly slowed the rate of wound closure in vivo and in vitro and resulted in a thicker epidermal layer after reepithelialization. Conversely, preventing Cx43 phosphorylation by mitogen-activated protein kinases (MAPKs) through mutation significantly increased the rate of wound closure in vivo. Defects in migration, but not proliferation, in all mutants were partially rescued in vitro by changing serine residues to aspartic or glutamic acid. These data prove that specific Cx43 phosphorylation events play an important role at different stages of wound healing. Thus, a clear physiological understanding of the spatiotemporal regulation of kinase activation and consequent effects on gap junctions could lead to a more targeted approach to modulating Cx43 expression during wound healing.
Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia
Authors: MOTIANI KUMAIL K. , COLLADO M. CARMEN , ESKELINEN JARI-JOONAS , VIRTANEN KIRSI A. , LÖYTTYNIEMI ELIISA , SALMINEN SEPPO , NUUTILA PIRJO , KALLIOKOSKI KARI K. , HANNUKAINEN JARNA C.
Published: August 2019

Introduction

Intestinal metabolism and microbiota profiles are impaired in obesity and insulin resistance. Moreover, dysbiotic gut microbiota has been suggested to promote systemic low-grade inflammation and insulin resistance through the release of endotoxins particularly lipopolysaccharides. We have previously shown that exercise training improves intestinal metabolism in healthy men. To understand whether changes in intestinal metabolism interact with gut microbiota and its release of inflammatory markers, we studied the effects of sprint interval (SIT) and moderate-intensity continuous training (MICT) on intestinal metabolism and microbiota in subjects with insulin resistance.

Methods

Twenty-six, sedentary subjects (prediabetic, n = 9; type 2 diabetes, n = 17; age, 49 [SD, 4] yr; body mass index, 30.5 [SD, 3]) were randomized into SIT or MICT. Intestinal insulin-stimulated glucose uptake (GU) and fatty acid uptake (FAU) from circulation were measured using positron emission tomography. Gut microbiota composition was analyzed by 16S rRNA gene sequencing and serum inflammatory markers with multiplex assays and enzyme-linked immunoassay kit.

Results

V˙O2peak improved only after SIT (P = 0.01). Both training modes reduced systematic and intestinal inflammatory markers (tumor necrosis factor-α, lipopolysaccharide binding protein) (time P < 0.05). Training modified microbiota profile by increasing Bacteroidetes phylum (time P = 0.03) and decreasing Firmicutes/Bacteroidetes ratio (time P = 0.04). Moreover, there was a decrease in Clostridium genus (time P = 0.04) and Blautia (time P = 0.051). Only MICT decreased jejunal FAU (P = 0.02). Training had no significant effect on intestinal GU. Colonic GU associated positively with Bacteroidetes and inversely with Firmicutes phylum, ratio Firmicutes/Bacteroidetes and Blautia genus.

Conclusions

Intestinal substrate uptake associates with gut microbiota composition and whole-body insulin sensitivity. Exercise training improves gut microbiota profiles and reduces endotoxemia.
Augmented-Feedback Training Improves Cognitive Motor Performance of Soccer Players
Authors: HICHEUR HALIM , CHAUVIN ALAN , CAVIN VINCENT , FUCHSLOCHER JOERG , TSCHOPP MARKUS , TAUBE WOLFGANG
Published: August 2019

Purpose

In this study, we tested the hypothesis that augmented feedback (AF) training can improve both perceptual–cognitive and/or motor skills specific to soccer.

Methods

Three groups of young elite players (U14–U15 categories) performed a test consisting in passing the ball as accurately and as quickly as possible toward a visual target moving briefly across a large screen located at 6 m from the player. The performed task required players to correctly perceive the target, anticipate its future location, and to adequately adjust the pass direction and power. The control group (CON) performed normal soccer training and was compared with two visuomotor training groups (AF and no-feedback [NF]) that followed the same training regime but integrated series of 32 passes three times per week over a 17-d period into their normal soccer training. Objective measurements of the passing performance were provided using a high-technology system (COGNIFOOT) before, during, and after training. During training, only players of the AF group received visuoauditory feedback immediately after each trial informing them about the accuracy of their passes.

Results

The results show that only players of the AF group significantly improved passing accuracy, reactiveness, and global passing performance (+22%), whereas the NF group only improved passing accuracy. None of these parameters was improved in the CON group. The objectively measured changes in passing performance were compared with the more subjectively judged passing performance provided by coaches and players. Coaches’ judgments were more reliable than players’ judgments and exhibited a training group effect comparable to the ones objectively measured by COGNIFOOT.

Conclusions

This study provides evidence that the training of cognitive motor performance in soccer players highly benefits from the use of augmented feedback.
Τα τρία φεγγάρια στη Ρίβα
Authors: Γαραντούδης Ευριπίδης
Published: August 2019

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Visceral leishmaniasis (Kala-azar) in Qom Province, Iran: Report of two cases
Authors: Zanjirani Farahani Leyli , Saghafipour Abedin , Mohebali Mehdi , Akhoundi Behnaz , Raufi Hedayatollah
Published: August 2019

Visceral leishmaniasis (VL) is a fatal parasitic zoonotic worldwide disease, which transmits to humans by the infected Phlebotomine sand fly bite. The common form of VL in Iran is the Mediterranean type with the causative agent of Leishmania infantum, whose main reservoirs are stray and domesticated dogs. The disease has several endemic foci in Iran, mostly seen among children under the age of 10, living in rural areas and nomadic tribes. The first cases of Kala-Azar in Qom province, central Iran, were reported in the year 2001, from the villages of Ghahan district. After conducting VL control strategies in the area, no new cases of the disease had been reported until recently. The cases described here are two 2-year-old girls, living in the urban parts of Qom province, one of whom did not have a history of traveling to known endemic areas of the disease. The patients were admitted to hospital in 2016-2017, complaining from recurrent fever with unrecognized reason, associated with decreased appetite and weight loss. Disease follow-up demonstrated anemia and splenomegaly, which led to diagnosis of VL, and both patients are now fully recovered. VL was presumed to be controlled in Qom province but the present cases indicate that possible VL existence remains in the region. Therefore, urgent studies and periodic monitoring are needed to identify potential reservoirs of VL in the area.
Curation of an intensive care research dataset from routinely collected patient data in an NHS trust.
Authors: McWilliams Chris , Inoue Joshua , Wadey Philip , Palmer Graeme , Santos-Rodriguez Raul , Bourdeaux Christopher
Published: August 2019

In this data note we provide the details of a research database of 4831 adult intensive care patients who were treated in the Bristol Royal Infirmary, UK between 2015 and 2019. The purposes of this publication are to describe the dataset for external researchers who may be interested in making use of it, and to detail the methods used to curate the dataset in order to help other intensive care units make secondary use of their routinely collected data. The curation involves linkage between two critical care datasets within our hospital and the accompanying code is available online. For reasons of data privacy the data cannot be shared without researchers obtaining appropriate ethical consents. In the future we hope to obtain a data sharing agreement in order to publicly share the de-identified data, and to link our data with other intensive care units who use a Philips clinical information system.
Antioxidant activity of extracted green algae silpau (Dyctyosphaeria versluysii)
Authors: SRIMARIANA ENDANG S , APITULEY DAN
Published: August 2019

Abstract. Srimariana ES, Apituley DAN. 2019. Antioxidant activity of extracted green algae silpau (Dyctyosphaeria versluysii). Nusantara Bioscience 11: 153-156. Silpau (Dictyosphaeria versluysii) is a green algae that is widely available in Southwest Moluccas regency, living on coral reefs and not classified as seasonal plants. Silpau has long been used by local people, generally in the form of processed vegetables or colo-colo (traditional food). Except for its nutritional value, comprehensive information about silpau still unknown. Therefore, this study was carried out to determine its potential as an antioxidant. The phytochemical content of silpau was analyzed according to the standard method. The antioxidant activity of green algae silpau extract was carried out by reducing DPPH (1,1-diphenyl-2-picrylhydrazyl) free radicals. Phytochemical test of silpau revealed that silpau contain terpenoid compounds. The result of the study showed that the IC50 value of methanol extract of silpau was 547.97 ppm, indicated that silpau methanol extract categorized as a weak antioxidant.
A aplicação da aromaterapia como método de alívio da dorem gestantes: uma revisão integrativa
Authors: Silva Sandra Cristina de Souza Borges , Medina Edymara Tatagiba , Oliveira Temistocles Barroso de , Valverde Simone Sacramento
Published: August 2019

Estudo acerca das intervenções terapêuticas com Aromaterapia, implementadas pela enfermeira em gestantes queixosas de dor. A investigação teve como objetivos identificar a ação analgésica do óleo essencial de lavanda, a ser aplicado em gestantes, assim como descrever os resultados deste cuidado. Trata-se de uma revisão integrativa de literatura, onde utilizou-se a estratégia SPIDER, guiada pela questão norteadora “Quais óleos essenciais possuem ação analgésica durante a gestação?”. Por meio de pesquisa nas bases de dados Medical Literature Online (MEDLINE), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Bases de Dados de Enfermagem (BDENF), Scientific Electronic Library Online (SciELO), portal da Biblioteca Virtual de Saúde (BVS) e PUBMED, foram selecionados 15 artigos que corresponderam aos objetivos definidos, distribuídos no recorte temporal de 2000 a 2016. Os resultados apontaram a utilização apenas em mulheres durante trabalho de parto e o óleo essencial de lavanda (Lavandula angustifolia) como o mais utilizado, devido às suas ações ansiolítica e analgésica.
O ensino de ciências e os laboratórios escolares no Ensino Fundamental
Authors: Cardoso Santana Salete De Lourdes , Castro Pessano Edward Frederico , Fidélis Escoto Dandara , Da Cruz Pereira Geovana , Alves Ortiz Gularte Cláudia , Folmer Vanderlei
Published: August 2019

Este estudo tem como objetivo analisar o ensino de ciências no Ensino Fundamental no que se refere a presença e uso dos laboratórios escolares. No RS, tais espaços são exigidos nas escolas como condição para a oferta do ensino médio no Sistema Estadual, conforme Parecer 580/2000-CEEd/RS. Por considerarmos importante que os ingressantes no ensino médio possuam essa vivência, propusemos este trabalho, que busca responder a duas indagações: existem laboratórios de ciências nas escolas públicas de Ensino Fundamental? Se existem, são utilizados? Para isso, foi feita uma pesquisa que envolveu 35 escolas públicas das cidades de Barra do Quaraí e Uruguaiana, localizadas na fronteira oeste do RS, abrangendo um público total de 1430 alunos, 46 professores da área e 37 gestores. A coleta de dados contou com aplicação de um questionário semiestruturado, contendo questões abertas e fechadas. A análise mostrou que, das 35 escolas, apenas 16 possuem laboratório de ciências, representando 45,7%. Portanto, 19 escolas, totalizando 54,3% estão sem laboratório. Destas, cinco oferecem o Ensino Médio, o que representa cerca de 26%. Sobre o uso, dentre as que possuem, seis utilizam o espaço, com regularidade ou não, e que cinco não os utilizam. As alegações vão desde a estrutura até “falta de hábito”. Com este estudo, espera-se trazer para os laboratórios um novo olhar, para que sejam utilizados como complemento às aulas de Ciências, pois a sua inserção poderá pode trazer vários benefícios, como contribuir no aumento das médias, na diminuição das faltas e na motivação do aluno em aprender ciências.
Em Cinema & Humanidades, exercícios de aproximação entre o cinema e outros campos do conhecimento
Authors: Martins Alice Fátima
Published: August 2019

Recensão crítica do livro Cinema & Humanidades: ensaios multidisciplinares, organizado por Samir Perrone de Miranda, e publicado pela Editora UFPB, em 2013.
A inteligência de uma atriz-máquina. Entrevista com Hazel Orencio, estrela e braço direito do realizador filipino Lav Diaz
Authors: Ramos Monteiro Lúcia , Dumas Clément
Published: August 2019

Nascida em 1986 em Antipolo, no norte das Filipinas, Hazel Tapales Orencio estudou teatro na Universidade Politécnica das Filipinas e desde então vem trabalhando como atriz no teatro e no cinema. Ela trabalha intensamente com Lav Diaz, tanto como atriz quanto como uma espécie de braço direito do realizador independente, figura de proa de um grupo conhecido atualmente como "a nova Era de Ouro" do cinema nacional. Parte das cerca de dez pessoas que costumam trabalhar com Lav Diaz – o "skeleton crew", como costumam autodenominar-se – ela se alterna entre assistência de direção, gerência de produção, direção de casting, design de produção, design de figurino... E é responsável pela maior parte das legendas de seus filmes. Premiada por sua performance e selecionada para mostras competitivas em alguns dos mais importantes festivais do mundo (Cannes, Locarno, Veneza, Berlim), ela vive modestamente em um país onde a cultura, para o bem e para o mal, não está entre as principais preocupações da política. Nesta entrevista, que ocorreu em diversas sessões entre fevereiro e abril de 2019, seu último filme com Lav Diaz (Ang Hupa, 2019) estava sendo editado. Em uma conversa por e-mail e Skype, Hazel Orencio fala de atuação, do método Lav Diaz e de trabalhar nas Filipinas de Rodrigo Duterte – o que pode significar filmar na Malásia e andar pelas ruas sob disfarce.
KNOWLEDGE AS IDENTITY: AN ESSAY IN GENEALOGY
Authors: RISTIĆ DUŠAN , MARINKOVIĆ DUŠAN
Published: August 2019

In this research, we analyze the nexus between knowledge and identity as a problem of the sociology of knowledge. Our aim is to present the genealogical framework with the hypothesis that if we accept that knowledge is a multi-discursive phenomenon, then one way of justifying and stabilizing knowledge in social practices is through the concept of identity. We single out the problem of “locality” of discourses and practices and present the “genealogical paths” through which knowledge and identity are intertwined. Furthermore, our attempt is to identify the specific historical relations of knowledge and identity – through the discursive practices and especially in the context of Enlightenment and the claims for “universal knowledge” as part of the process of the formation of what could be called European identity.
Social control of spermatogenesis and steroidogenesis in cichlid fish: a comparative approach
Authors: Scaia María Florencia , Cavallino Luciano , Pandolfi Matías
Published: August 2019

Social animals with hierarchical dominance systems are susceptible to changes their environment. Interactions with conspecifics can greatly affect individual’s behavior and reproductive success. This review will show how social behavior modulates gonadal steroidogenesis and spermatogenesis in African and Neotropical cichlid fish with different social systems and how this modulation regulates reproductive capacity. Social behavior and aggressiveness are strongly linked to sex steroids, glucocorticoids and neuropeptides. The challenge hypothesis suggests that behavioral interactions increase androgen levels in response to social instability, but there is little evidence regarding estradiol levels. It has been recently demonstrated that in male Cichlasoma dimerus, a Neotropical cichlid fish, the challenge hypothesis could also be extended to estrogens. In C. dimerus, dominant males have higher gonadosomatic index than subordinated; the percentage of spermatocytes and spermatids is higher in subordinates, while dominants show a greater percentage of spermatozoa. In other species of African cichlids, socially suppressed subordinate males are not reproductively incompetent maintaining some activity at every level of their reproductive axis. Axis reactivation upon social ascent is similar to the initiation of puberty in mammals, as well as the reoccurrence of puberty observed in seasonally breeding animals. In conclusion, social behavior and reproductive strategies in females cichlids are still understudied, and Neotropical cichlids still constitute a group that deserves more attention, considering cichlids’ diversity in mating systems, reproductive behavior and parental care. This review highlights the importance of performing further studies and additional research in these two areas, which still remain to be addressed.
Propuesta curricular desde un enfoque bimodal y un multimedia informativo para el curso Recursos Didácticos para la Enseñanza del Inglés
Authors: Saborío-Taylor Silvia
Published: August 2019

La investigación se realizó con el objetivo de diseñar una propuesta curricular con un enfoque bimodal para el curso “Recursos Didácticos para la Enseñanza del Inglés” y un multimedia informativo. Se estructuró una metodología en dos etapas: la construcción de una nueva propuesta curricular para impartir el curso bimodal basado en la conceptualización y diseño de recursos tecnológicos; así como la producción de un multimedia informativo para la implementación de recursos didácticos tecnológicos, acorde con la propuesta curricular. Para validar la propuesta y la evaluación del multimedia se llevó a cabo un proceso de investigación evaluativa, por lo que se utilizaron como instrumentos de recolección de datos un análisis de fortalezas, oportunidades, debilidades y amenazas (FODA) (para el estudiantado que recibió el curso) y dos cuestionarios (para docentes en el área de inglés y artes gráficas). Se determinó que la propuesta curricular cuenta con una serie de fortalezas y oportunidades; de igual forma el material multimedia se considera como una herramienta didáctica pertinente para la incorporación de las TIC en la enseñanza del inglés. Por tanto, el proceso de investigación demostró que se logró un efectivo y novedoso diseño de propuesta curricular con un enfoque bimodal y que el multimedia representó un medio de innovación para los recursos didácticos utilizados en el proceso de aprendizaje del inglés.
Opinión de futuros equipos docentes de educación primaria sobre la implementación del mobile learning en el aula
Authors: Hinojo Lucena Francisco Javier , Aznar-Díaz Inmaculada , Cáceres-Reche María Pilar , Romero-Rodríguez José María
Published: August 2019

Las tecnologías de la información y comunicación (TIC) son una tendencia a implementar en el ámbito educativo. En concreto, la universalización en el uso de los dispositivos móviles ha posibilitado su aplicación en diferentes etapas educativas. El objetivo de este trabajo ha sido conocer la opinión de futuros equipos docentes de educación primaria sobre la implementación del mobile learning en el aula. La metodología empleada es de corte cuantitativo, con la finalidad de describir la realidad observada en una muestra de estudiantado universitario del grado en Educación Primaria de la Universidad de Granada. Así mismo, se utilizó como instrumento de recogida de datos un cuestionario elaborado ad hoc, con base en una escala Likert de 4 niveles. El análisis de los datos se ha realizado mediante el software de análisis estadístico SPSS y AMOS. Entre los resultados se resalta la percepción positiva del estudiantado sobre la incorporación de la metodología mobile learning en educación primaria, así como la adecuación en el uso de tecnologías móviles emergentes como la realidad aumentada y realidad virtual. Por último, se discuten distintas implicaciones y recomendaciones sobre la aplicación de los dispositivos móviles en el aula, entre ellas la generalización de estos recursos en este espacio, reticencias que todavía existen por parte del personal docente (maestros y maestras) y la mejora del aprendizaje estudiantil.
Chilean Graders’ Behaviors and Perceptions of a Foreign Language Reschooling Program Towards Verbal Feedback on Pronunciation
Authors: Calisto-Miranda Sebastián , Ortiz-Navarrete Mabel
Published: August 2019

This research study aims to provide graders of an EFL reschooling program with individual verbal feedback and analyze their behaviors and perceptions towards the intervention. This study follows an action research design conducted during three sessions in which 28 secondary school students had a dialogue with the teacher who commented on their pronunciation issues and provided with strategies in order to help them deal successfully with pronunciation issues. A field note and a semi-structured interview were used to collect data. The field note was used during the dialogue to observe students’ behavior towards the feedback; the semi-structured interview was implemented after the intervention in order to describe their perceptions towards the methodology and its effect on their learning process. Thematic analysis was used to identify certain patterns of meanings; the analysis showed findings leading to the conclusion that students felt more comfortable when facing speaking activities because of the practice and repetition during the individual verbal feedback stage. Future studies could include peer feedback, because this verbal feedback may be enhanced if students work in pairs. This type of strategy may favor discussion and clarification of doubts.
Mental Health, Drug, and Violence Interventions for Sexual/Gender Minorities: A Systematic Review
Authors: Coulter Robert W. S. , Egan James E. , Kinsky Suzanne , Friedman M. Reuel , Eckstrand Kristen L. , Frankeberger Jessica , Folb Barbara L. , Mair Christina , Markovic Nina , Silvestre Anthony , Stall Ron , Miller Elizabeth
Published: August 2019

CONTEXT:

Compared with cisgender (nontransgender), heterosexual youth, sexual and gender minority youth (SGMY) experience great inequities in substance use, mental health problems, and violence victimization, thereby making them a priority population for interventions.

OBJECTIVE:

To systematically review interventions and their effectiveness in preventing or reducing substance use, mental health problems, and violence victimization among SGMY.

DATA SOURCES:

PubMed, PsycINFO, and Education Resources Information Center.

STUDY SELECTION:

Selected studies were published from January 2000 to 2019, included randomized and nonrandomized designs with pretest and posttest data, and assessed substance use, mental health problems, or violence victimization outcomes among SGMY.

DATA EXTRACTION:

Data extracted were intervention descriptions, sample details, measurements, results, and methodologic rigor.

RESULTS:

With this review, we identified 9 interventions for mental health, 2 for substance use, and 1 for violence victimization. One SGMY-inclusive intervention examined coordinated mental health services. Five sexual minority–specific interventions included multiple state-level policy interventions, a therapist-administered family-based intervention, a computer-based intervention, and an online intervention. Three gender minority–specific interventions included transition-related gender-affirming care interventions. All interventions improved mental health outcomes, 2 reduced substance use, and 1 reduced bullying victimization. One study had strong methodologic quality, but the remaining studies’ results must be interpreted cautiously because of suboptimal methodologic quality.

LIMITATIONS:

There exists a small collection of diverse interventions for reducing substance use, mental health problems, and violence victimization among SGMY.

CONCLUSIONS:

The dearth of interventions identified in this review is likely insufficient to mitigate the substantial inequities in substance use, mental health problems, and violence among SGMY.