bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFECT OF INTRAVESICAL CHEMOTHERAPY, MODIFIED BY ELECTROMAGNETIC FIELD IN THE SCANNING MODE, ON THE LEVEL OF ENDOTOXEMIA AND OXIDATIVE PROCESSES IN THE BLOOD IN PATIENTS WITH BLADDER CANCER
Authors: Goroshinskaya Irina A. , Shevchenko A. N , Filatova E. V , Kachesova P. S , Nemashkalova L. A , Chudilova A. V
Published: September 2020

Muscle-non-invasive bladder cancer (MNIBC) accounts of 70% of malignant lesions of this localization and has a high rate of recurrence and complications after treatment that requires improvement of the management of such patients. The developed modification of adjuvant intravesical chemotherapy (IVCT) necessitates the evaluation of endotoxemia and the adequacy of antioxidant protection of patients. The purpose of the study is the assessment of indices that reflect the functional state of albumin, the severity of endogenous intoxication (EI) and the state of free radical oxidation in the blood of MNIBC patients receiving adjuvant IVCT modified by the influence of scanning electromagnetic field. Material and methods. Endogenous intoxication indices, the light sum of peroxide induced luminol dependent chemiluminescence, malondialdehyde (MDA) content, activity of superoxide dismutase, catalase and glutathione system were investigated in the blood of MNIBC 30patients receiving chemotherapy under the impact of electromagnetic field during the process of dynamic monitoring of patients in comparison with a group of healthy persons. Results. Before treatment, MNIBC patients were characterized by the increased content of medium mass molecules (MMM) by 34-80% and decreased albumin binding capacity by 20%, that leading to an increase of EI coefficient by 81%, indicating to the presence of EI. The observed increase in the intensity, accumulation of molecular products of lipid peroxidation and the low level of activity of the main antioxidant enzymes indicated to the contribution of free radical processes in the metabolic state of these patients. After completion of adjuvant IVCT under simultaneous exposure to the local scanning electromagnetic field the decrease of main markers of endotoxemia - MMM254 and MMM280 was revealed. Full restoration of the albumin binding capacity and balanced operation of the antioxidant system was observed 9 months after the surgery. Conclusion. Biochemical data are consistent with the clinical efficacy of adjuvant IVCT combined with the scanning magnetic field, which allows to improve indices of 2-year disease-free survival to 94% and to double the latency period of relapse.
PROPHYLAXIS AND TREATMENT OF SIDE EFFECTS OF ANTIANGIOGENIC THERAPY IN PATIENTS WITH METASTATIC COLORECTAL CARCINOMA
Authors: Meshcheryakov Andrey A.
Published: September 2020

The review analyzed data from the literature and personal experience of the application of anti-angiogenic therapy in metastatic colorectal cancer. There are presented practical advices on prevention and treatment of the most common side effects of anti-angiogenic therapy.
NEW IMMUNOLOGICAL CHECKPOINTS FOR CANCER IMMUNOTHERAPY
Authors: Chapoval Andrei I. , Podlesnykh S. V , Kolosova E. A , Shcherbakov D. N
Published: September 2020

Members of B7-CD28 family ligands and receptors play the important role in the co-stimulation and inhibition of the T-cell mediated immune response. Blocking of the B7 family molecules inhibiting the immune response (also called immunological checkpoints), CTLA4 and PD-1 / PD-L1 promoted to important therapeutic achievements in cancer immunotherapy and improved survival of cancer patient. The recent discovery of new B7 family molecules (such as B7-H3 [CD276], B7-H4 [B7S1 / B7x / Vtcn1], B7-H5 [VISTA / PD-1H / GI24], B7-H6 and B7-H7 [HHLA2]) has expanded therapeutic possibilities for the management of cancer patients. In this article, we discuss the clinical application of known blockers of immunological checkpoints and the prospects for the use of newly discovered molecules.
MOLECULAR GENETIC TESTING IN DIAGNOSTICS OF LUNG CANCER AND OVARIAN CARCINOMA WITH THE USAGE OF CYTOLOGICAL SPECIMENS
Authors: Grigoruk Olga G. , Pupkova E. I , Bazulina L. M , Lazarev A. F
Published: September 2020

This article presents results of the introduction in practical oncology of molecular genetic investigations performed with the use of tumor DNA cells taken from the cytological specimens. There was investigated the molecular genetic characteristics of cytological specimens from 126 patients. In 80 cases with the proved diagnosis of pulmonary adenocarcinoma (n = 80) EGFR gene mutations were noted in 11.7% cases. KRAS, BRAF and BRCA1/2 gene mutations were determined in 46 women suffering from serous ovarian carcinoma. KRAS gene mutations in cells of ovarian low-grade serous carcinoma were determined in 62.5% of patients, BRAF- in 12.5% cases. BRCA1 gene mutations have been determined in 14.3% cases from the ovarian high-grade serous carcinoma group. In conditions of the presence of the sufficient amount of tumor cells the cytological material is the fully-featured material for molecular genetic investigations. The investigation both of EGFR gene mutations in pulmonary adenocarcinoma cases and KRAS, BRAF, BRCA1/2 gene mutations with serous ovarian carcinoma are mandatory in the appointment of targeted therapy.
EXPERIENCE OF APPLICATION OF IPILIMUMAB IN COMBINED THERAPY OF SMALL-CELL LUNG CANCER. ANALYSIS OF DATA OF THE MULTICENTER RANDOMIZED RESEARCH CA 184-156, PHASE III
Authors: Kuzminov Aleksandr E. , Bagrova S. G , Gorbunova V. A
Published: September 2020

Patients with advanced small cell lung cancer (SCLC) have an extremely poor prognosis against a background of standard therapy with a combination of etoposide with platinum drugs. In a randomized, double-blind of the CA184-156 phase 3, the efficacy and safety of ipilimumab or placebo in combination with etoposide and platinum preparations was evaluated as the first line treatment for disseminated SCLC. Material and methods. Randomization of patients was carried out in a ratio of 1:1 in the group of therapy: etoposide + platinum drug (carboplatin or cisplatin) + ipilimumab and etoposide + platinum preparation + placebo. Ipilimumab/placebo was administered at a dose of 10 mg/kg every 3 weeks, starting from the 3rd course of chemotherapy to the 6th course of chemotherapy. Further, in the absence of progression, maintenance therapy with ipilimumab/placebo was performed every 12 weeks. The main end point of the study was the assessment of overall survival (OS). Results. Out of 1,132 randomized patients, 954 received at least 1 administration of ipilimumab/placebo in combination with chemotherapy: ipilimumab, n = 478; placebo, n = 476. Median OS was 11.0 months in the chemotherapy group with ipilimumab and 10.9 months, in the chemotherapy group with placebo (RR, 0.94, 95% CI, 0.81-1.09, p =0,3775). The median progression-free survival was 4.6 months in the chemotherapy group with ipilimumab and 4.4 months in the chemotherapy group with placebo. (RR, 0.85, 95% CI, 0.75-0.97). The frequency and severity of side effects in the compared groups was similar, with the exception of diarrhea, rash, and colitis, which occurred significantly more frequent in the chemotherapy group with ipilimumab. The frequency of the discontinuation of therapy due to toxicity was higher in the chemotherapy group with ipilimumab (18% vs. 2%). Treatment-related deaths accounted for 5 in the chemotherapy group with ipilimumab and 2 - in the chemotherapy group with placebo. Conclusion. The addition of ipilimumab to chemotherapy did not contribute to an increase in OS in comparison with only chemotherapy in advanced SCLC patients. Unexpected adverse events in the chemotherapy group with ipilimumab were not noted. The study of the efficacy of ipilimumab in patients with disseminated SCLC in combination with PD1 inhibitors is ongoing. The results obtained in the analysis of data in a subset of 33 patients who participated in this study on the basis of the Department chemotherapy of N.N. Blokhin Russian Cancer Research Center, correspond to data obtained in the entire multicenter study CA184-156.
LEVELS OF GROWTH FACTORS AND THEIR RECEPTORS IN INTACT AND TUMOR TISSUES OF FEMALE MICE IN DYNAMICS OF THE MALIGNANT MELANOMA GROWTH
Authors: Kit O. I , Frantsiyants E. M , Bandovkina Valeriya A. , Kaplieva I. V , Trepitaki L. K , Rozenko L. Ya , Cheryarina N. D , Pogorelova Yu. A , Shulga A. V
Published: September 2020

The formation and growth of the tumor are accompanied with the development of new vasculature providing the neoplasm with nutrients for its growth and metastasis. Main agents for these processes are VEGF family that can be activated by various ways, including insulin growth factor (IGF) effects, epidermal growth factors (EGF), transforming growth factors (TGF) and fibroblast growth factor (FGF). The study included female C57BL/6 mice (n = 40) with B16/F10 melanoma transplanted subcutaneously. Changes in levels of VEGF-A, VEGF-C, VEGF-D and their receptors R1, R2 in dependence on the activity of IGF-I, IGF-II, EGF and FGF21 were studied by ELISA in tumor, perifocal area and intact tissues in the dynamics of B16/F10 melanoma growth using standard test systems. VEGF-A and VEGF-C were first to be activated in intact tissue of female mice with transplanted tumors, even prior to the tumor formation, which created conditions for the growth and development of the malignant tumor stroma. Later development of B16 melanoma was accompanied by the enhanced expression of VEGF growth factors and receptors in tumor and surrounding tissues. Main factors triggering angiogenesis in all samples included IGF2 and IGF1 which levels in the dynamics of melanoma growth correlated with VEGF-A values in tumor, its perifocal zone and intact tissues, and with VEGF-C in non-malignant tissue. The study demonstrated the multifactor staged activation of neoangiogenesis not only in B16 melanoma tissue but in surrounding and intact tissues as well.
SENSITIVITY OF HUMAN TUMORS WITH VARIOUS EXPRESSION OF RECAF RECEPTOR TO AFP-CONTAINING COMPLEX OF AIMPILA IN VIVO
Authors: Smirnova Galina B. , Tsurkan S. A , Borisova Yu. A , Tcherkassova J. R , Romanenko V. I , Kalishian M. S , Treshalina H. M
Published: September 2020

Experimental studies were carried out with non-covalent complex AIMPILA targeting on AFP receptors (ReCAF). The human subcutaneous xenografts were used with different ReCAF containing transplanted to immunodeficient mice Balb/c nude: colon cancer SW620/ReCAF +, liver cancer HepG2/ReCAF + + and breast cancer T47D/ReCAF + + +. IMPILA was administrated per os under beginning on 4th day after tumor transplantation daily for 5 or 10 days in the total doses of 0.5-2.0 mg/kg or 1.0-4.0 mg/kg, accordingly. The inhibiting effect (T/C < 42%) of AIMPILA was shown to increase in dependence on ReCAF containing on tumor cells: T/C = 70% (SW620/ReCAF +); T/C = 51% (HepG2/ReCAF + +) and T/C = 22% (T47D/ReCAF+++). On the more sensitive model in a series of experiences 10-times course for the treatment with the total dose of 4.0 mg/kg was detected and revealed to T/C = 15-37% (p < 0.05). In the pathomorphological investigation of the T47D/ReCAF+++ tumor there was verified the death of the majority of tumor cells under the treatment of AIMPILA via the apoptosis pathway.
COMPARATIVE ANALYSIS OF BREAST CANCER PREVALENCE RATE OF THE OF URBAN AND RURAL FEMALE POPULATION OF THE REPUBLIC OF KHAKASSIA
Authors: Chernenko Olga N. , Borisov O. B , Dykhno Yu. A
Published: September 2020

In article the comparative characteristic of a morbidity rate of the breast cancer (BC) of urban and rural female population of the Republic of Khakassia in 1999-2013 is given. The main tendencies of the dynamics of a BC prevalence rate are revealed: the more pronounced gain in the morbidity rate of the urban population (Abakan), the significant growth in the prevalence rate in the female population of districts of the Republic; the increase of the number of cases in working-age women
INNOVATIVE APPROACH TO TRAINING STUDENTS OF THE MEDICAL UNIVERSITY TO THE MANUAL METHOD OF THE EXAMINATION OF THE BREAST IN MASTOPATHY AND CANCER
Authors: Dykhno Yuri A. , Kazanceva T. V , Turchina G. E , Archipova G. A
Published: September 2020

Training future doctors is inextricably linked with the development of manual skills examination of mammary glands. To improve this research there were created videos reflecting stages of the examination on the Phantom and the patient, and the check-list. Overall, this has resulted in not only perfection in the performing such manipulation, but single interpretations of results. Check-list is both used on the outside-and classroom and practical exam of the final appraisal in students, and also was introduced in the work of the Krasnoyarsk regional Clinical Oncology Center.
TYROSINE KINASE INHIBITORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER
Authors: Sletina Svetlana Yu. , Poddubskaya E. V
Published: September 2020

Considering the findings regarding the excellent frequency response (approximately 70%), survival without disease progression (median approximately of 9 months), better safety profile and the superior quality of life for patients compared with standard chemotherapy, EGFR TKIs in EGFR mutation positive non-small cell lung cancer patients can be now considered as first-line treatment in these patients. Evaluation of epidermal growth factor receptor mutations is necessary for all non-small cell lung cancer patients as the effective prognostic marker of the response to tyrosine kinase inhibitors of EGFR.
Malignant neoplasms in the urban and rural population of the tomsk region
Authors: Pikalova L. V. , Odintsova I. N. , Zhuikova L. D. , Ananina O. A. , Lazarev A. F. , Startseva O. I. , Shelomentseva A. M.
Published: September 2020

Progress In the prevention and treatment of infectious diseases, aging of the population, environmental, economic and other factors cause changes in the structure of morbidity and mortality. Malignant neoplasms (ZNO), serving as one of the main causes of disability and occupying one of the leading places in the structure of mortality of the population, are one of the main problems of health care in Russia. The growth of cities radically changes the environment and human lifestyle, has an impact on the level and structure of morbidity of the population. A person in an urban environment is exposed to a complex of social and environmental factors. According to statistics, the incidence of ZNO urban population in Russia, higher than rural [1-5]. However, as the adverse effects of urbanization penetrate into the countryside, the introduction of the rural population to the urban way of life and the aging of the rural population, it is possible to predict an increase in morbidity among them. For the development of anti-cancer programs and adoption of reasoned management decisions, information on the spread of ZNO among the population of various administrative-territorial entities is needed, especially for areas with low population density, where, as a rule, the rural population lives. At the present stage, the study of epidemiological features of the prevalence of cancer in the Tomsk region is the most urgent organizational issue in connection with the need to plan anti cancer measures in the framework of the regional program Fight against cancer (hereinafter-the Program). Given that the financing of the Program is provided from 2019 to 2024, it seems appropriate to determine the structure of morbidity in the context of municipalities for adequate planning and ensuring the availability of specialized medical care. The aim of the study was to study the incidence of malignant neoplasms of urban and rural population of Tomsk region. The study used data from the population cancer register of the regional Oncology dispensary of the Tomsk region for the period from 2007 to 2017. and the Federal state statistics service of the Russian Federation on the population living in the region. The analysis of the epidemiological situation was carried out by extensive, intensive, standardized (direct method) indicators. Statistical processing of the material was carried out using the program ONCOSTAT.
THE EFFECT OF HERBAL MEDICINE ON THE IMMEDIATE INDICATORS OF HOMEOSTASIS IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER WHO RECEIVED SPECIAL TREATMENT
Authors: Korepanov S. V , Lazarev A. F , Petrova Valentina D.
Published: September 2020

Radiation therapy is the main method of treatment of locally advanced cervical cancer. However, this type of treatment, especially in combination with chemotherapy, often leads to complications from the indicators of homeostasis. The authors proposed to eliminate or mitigate hematological side effects to use as an accompanying therapy during chemo-radiation treatment of the original patented method of drugs from medicinal plants. There are Siberian ginseng (Eleutherococcus senticosus Maxim.), Badan (bergenia crassifolia), Birch buds (Gemmae Betulae), Pharmacy Chamomile (Matricaria Chamomilla), Plantago (Plantago major L.), St. John’s wort (Hypericum perforatum L. ), Licorice root (Glycirrhiza glabra uralensis L.), Bearberry (Arctostaphylos uva-ursi Spr.), Yarrow (Achillea millefolium L.), Dill (Anethum graveolens L.), Linseed (Linum usitatissimum L.) in the original method. In a randomized clinical trial in patients with locally advanced cervical cancer: primary group of 350 patients who received standard special chemo-radiation therapy on the background of the accompanying herbal medicine and a comparison group - 402 patients who received only standard, the special treatment have been examined a number of indicators of homeostasis. It was shown that in patients of the main group, the deviation from the normal level of blood parameters were less pronounced and returned to normal faster after treatment than in patients of the comparison group (p
Ripretinib (DCC-2618): a new tyrosine kinase inhibitor for the treatment of metastatic gastrointestinal stromal tumors
Authors: Filonenko D.. A , Tikhomirova T. E. , Meshcheryakov A. A.
Published: September 2020

Ripretinib (DCC-2618) is a novel tyrosine kinase inhibitor designed to broadly inhibit primary and secondary mutations in KIT (exons 9,11, 13, 14,17,18) and PDGFRA (exon 18). Here in our article we describe clinical trials of ripretinib for patient with advanced gastrointestinal stromal tumors (GIST).
The clinical trial INVICTUS-randomized phase III study of ripretinib for patient with advanced GIST in 4 lines therapy; it is the most important results, because there are currently no approved drugs for such patients. Median PFS was significantly improved with ripretinib compared with placebo 6,3 и 1 months (p0,0001) and median OS was significantly improved with ripretinib compared with placebo 15,1 и 6,6 months (p0,004).
High efficacy of ripretinib was accompanied with favorable profile of toxicity, only 8,2% patients experienced treatment discontinuations due to adverse events.
Treatment of relapses of gestational trophoblastic neoplasias
Authors: Meshcheryakova L. A. , Zharova A. S. , Maslennikov A. F. , Kuznetsov V. V. , Chekalova M. A. , Komarov I. G. , Davydova I. Yu. , Molchanov G. V. , Gigolaeva N. M. , Meshcheryakov A. A.
Published: September 2020

The purpose of the study: to present an experience of the N. N. Blokhin Russian Cancer Research Center in the treatment of relapses of gestational trophoblastic neoplasias (GTN).
Materials and methods. We performed a retrospective analysis of medical case histories at the N. N. Blokhin Russian Cancer Research Center from 1996 until 2019. 545 patients with GTN were treated. Relapses occurred in 25 (4.6%) patients: 8 (2.1%) patients with low risk of resistance (6 (75%) early relapses and 2 (25%) late relapses) and 17 (10%) patients with high risk of resistance (11 (65%) early relapses and 6 (35%) late relapses). Treatment of relapses was done by standard chemotherapy regimens (Dactinomycin 500mcg in days 15, EMA-CO, EMA-EP). Different surgical interventions and radiosurgery were used in some cases additionally.
Results. Out of 6 patients with early relapses of low-risk GTN, 5 were cured with chemotherapy and one patient by lung resection only. Two patients with late relapses of low-risk GTN were cured with chemotherapy (EMA-CO) and hysterectomy/resection of uterus to achieve complete remission. As a result, all patients with relapses of low-risk GTN were cured, mainly (88%) by chemotherapy. Among 11 patients with early relapses of high-risk GTN, complete remission was achieved in 6 (55%) cases: in 2 patients as a result of EMA-EP chemotherapy, other patients needed combined approaches (chemotherapy + surgery). Three patients with recurrent course continue treatment, two patients died of progression. Of the 6 patients with late relapses of high-risk GTN, 4 (66%) patients were managed mainly through combined treatment (surgery + chemotherapy) and were cured. One patient continues treatment for more than 4 years, and one patient died of progression. In total, out of 17 patients with high-risk relapses, complete remission was achieved in 10 (59%) as a result of combined treatment in the majority of cases (80%).
Conclusion. The optimal method of treatment for patients with relapses of low-risk GTN is chemotherapy; and for high-risk GTN combined approaches (chemotherapy + surgery)
Multislice computer tomography in detection of pseudocapsule of renal cell carcinoma
Authors: Filippova Ju. G , Ignatyev Yu. T , Leonov Oleg V. , Kharchenko T. V , Kopyltsov E. I , Podkorytov S. V
Published: September 2020

In order to evaluate the diagnostic efficiency of MDCT with bolus contrast enhancement in the visualization of renal cancer pseudocapsule a retrospective study, included 74 patients with histologically confirmed renal-cell cancer, was performed. Images were acquired in native, arterial, portal and nephrographic - excretory phase on a 64-detector CT scanner. The accuracy of MDCT in detecting pseudocapsule was determined by comparison with histological findings. Native axial images and multiplanar reformations were analyzed. According to the results of the study there was obtained high diagnostic efficiency of MDCT in detecting of the tumor pseudocapsule, that allows to use this method for the preoperative evaluation, assessment of the possibility ofperforming organ-saving surgery.
Rehabilitation of participants of battle actions: posttraumatic stress syndrome
Authors: Puzin S. N , Memetov Servir S. , Shurgaya M. A , Baleka L. Yu , Sumedi I. R , Muteva T. A
Published: September 2020

A negative psychical background is the imprint of smell ofpowder, hampering social and professional adaptation, and also interpersonal relations ofparticipants of battle actions. The study of level of socially-psychological adaptation of invalids and participants of battle actions showed that their considerable part (about 58%) has signs of zero adaptability, and in 12% of cases from this category the signs of complete social disadaptation are pronounced with the expressed negative reaction on situations, by irreconcilable attitude toward all surrounding, by the expressed protest reactions. The low level of adaptation of this category of persons is caused by the array of factors of both objective and subjective character. To the objective factors it is possible to refer socio-economic indexes, characterizing quality of the life of this contingent, state of health, weight of disability. However it is not always succeeded to observe the direct dependence between these indices and state of adaptation. It is explained by subjective psychological descriptions. The psychological consequences of traumatic stress determine the special requirement of contingent of private traders of battle actions in a socially-psychological rehabilitation. In cases of expressed posttraumatic stress disorders, socio-psychological disadaptation of persons from a number the veterans of battle actions, individual work is required after a vocational orientation and further employment taking into account compensatory-adaptive possibilities of organism and features ofpsychical reactions for the servicemen injured as a result of armed conflict.
A comparative analysis of the medico-social characteristics of primary disability of the population of Saint Petersburg in comparison of periods: 2007-2009 and 2013-2015
Authors: Karasaeva Lyudmila A. , Kalichava A. Sh , Dubrovskaja N. V , Svetlichnaja I. V
Published: September 2020

The article presents the medical and social characteristics ofprimary disability in the period from 2007 to 2009 and from 2013 to 2015. In the article there are presented medical-social characteristics of the primary disability over the periods from 2007 to 2009 and from 2013 till 2015. There were analyzed extensive and intensive indices of the primary disability which manifest as dynamics characteristics of the public health ofthe adult population of St. Petersburg. There were revealed clear cut downward trends in the number ofpersons for the first time recognized as disabled and the level of the primary disability in a major metropolis. There is established a consistent trend of the increase of specific weight of working-age persons for the first time recognized as disabled in the total number of the disabled adult population. In the compared periods there were revealed trends of increasing of the specific gravity of cases for the first time recognized as disabled at a young age. The use of indices obtained in the study can serve as the basis for the analysis and evaluation of the activities of the Bureau of the Socio-Medical Expertise in the modern conditions.
Personality characteristics of patients with fibro-cavernous pulmonary tuberculosis
Authors: Gurova Ya. V , Udalova T. Yu , Mordyk A. V , Bagisheva Natalia V. , Rudenko S. A , Fefelov I. D
Published: September 2020

There is represented to be relevant to clarify what personal characteristics contribute to the formation of fibro-cavernous tuberculosis, to prevent its formation in the course of treatment. The aim is to identify the personal features ofpatients with fibro-cavernous pulmonary tuberculosis to develop psychological support in the subsequent treatment of newly diagnosed patients, preventing the formation of chronic specific process. Material and methods. 96 patients participated in a study: 48 cases with fibro-cavernous tuberculosis and 48 healthy volunteers. To study the personality characteristics there was used «Combined Personality Inventory (CPI)» based on the Raymond Cattell’s 16 Personality Factors (adaptation by G.A. Leevik). Results. In comparison with the control group patients with fibro-cavernous pulmonary tuberculosis had higher averages in scales A (reserved demeanor - openness), F (poverty - wealth of emotional reactions), Н (reservedness - activity in communication), L (credulity - suspicion), M (practical - dreamy style of thinking), N (easy - the sophistication of behavior), O (confidence - lack of confidence), Q1 (conservatism - the desire for new), Q2 (conformity - non-conforming), Q4 (relaxed - alertness), P (plasticity - rigidity) and Tr (anxiety). They have reduced the level of logical intelligence, they are both less balanced and easier to subjugate, not disciplined, have low self-control, low level of claims, a less favorable climate in the family, coupled with introversion. Conclusion. Thus, patients with fibro-cavernous tuberculosis are distinguished by reservedness in communications, reserved demeanor, suspicion, alertness, anxiety, lack of discipline, poor self-control. Creation of a special social and psychological support services for this group ofpatients can elevate the efficiency of the complex treatment and improve prognosis.
Therapy with valproate preparations in disabled epilepsy patients in the Republic of Komi
Authors: Penina G. O , Ponomareva Galina M.
Published: September 2020

Epilepsy is the widespread and hard to cure disease. The medico-social importance of the problem is caused by the fact that among patients with epilepsy there is a considerable share of able-bodied age persons, most part of whom fail to receive the adequate treatment. The aim of the work is an assessment of demographic indices in epilepsy patients, being on therapy by preparations of valproic acid and having the group of disability in the Komi Republic. By the method of continuous research there were studied data over the period from 2006 for 2009 in patients from the Komi Republic, being on monotherapy by preparations of valproic acid and polytherapy where one ofpreparations was valproic acid. Out of872 patients disability was established in 36% of cases. Most ofpatients were on monotherapy by preparations of valproic acid. In disabled patients, the symptomatic type of epilepsy was mainly observed and generalized toniko-clonic attacks occurred more often than others.
Overview of scales and questionnaires applied in the assessment of the «quality of life» for craniopharyngioma patients
Authors: Kutin Maxim A. , Sidneva Yu. G , Ionova T. I
Published: September 2020

In this article there was reviewed the literature devoted to the problem of the assessment of the quality of life ofpatients with craniopharyngiomas. The given article raises questions about the application of questionnaires for the assessment of the quality of life, inability to the use the self-assessment systems in the classic sense in patients with craniopharyngiomas, and the need for the doctor himself to deliver systems for the evaluation of results of the management and outcomes.
INNOVATIVE APPROACHES TO THE EMPLOYMENT OF DISABLED PERSONS WITH SEVERE DISABILITIES IN INDEPENDENT MOVEMENT
Authors: Karasayeva Lyudmila A. , Luchkevich V. S , Kalichava A. S , Vladimirova O. N
Published: September 2020

In the article there are substantiated organizational approaches to the employment of persons with disabilities in the independent movement with the use of information and communication technologies. There were evaluated activities of the employment service on the employment of people with disabilities in St. Petersburg for five years (2011-2015). There are presented data of clinical experts, social, psychological, socio-environmental characteristics of the 1120 invalids suffering from obliterating atherosclerosis of vessels of lower extremities, with disabilities in the independent movement. There was scientifically substantiated the possibility of the employment in special working conditions at home in the form of distance mode. There was recommended the algorithm for the mutual employment of specialists of the Bureau of the ITU and the employment service
REHABILITATION OF PATIENTS IN CHRONIC CRITICAL STATES DUE TO BRAIN DAMAGE IN CONDITIONS OF RESUSCITATION AND INTENSIVE CARE UNITS: THE EXPERIENCE OF THE FEDERAL RESEARCH AND CLINICAL CENTER
Authors: Grechko A. V , Molchanov I. V , Petrova M. V , Pryanikov Igor V.
Published: September 2020

The article presents the experience of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology for the organization of medical care for patients in long-term (chronic) critical conditions due to the craniocerebral trauma, stroke, and surgical treatment of brain tumors who needs to be provided the functioning of vital organs against the background of prolonged impairment of consciousness, including methods of excommunication from the apparatus of artificial ventilation, medical correction of the level of consciousness, adequate general symptomatic treatment, nutritional-metabolic therapy and early rehabilitation by multidisciplinary medical teams.
MAIN PROBLEMS OF THE ORGANIZATION OF THE REHABILITATION OF CHILDREN WITH CONSEQUENCES OF NEUROINFECTION AND ORGANIC PATHOLOGY OF THE NERVOUS SYSTEM IN VARIOUS REGIONS OF THE RUSSIAN FEDERATION
Authors: Vishnyakov N. I , Kochorova Larisa V. , Samojlova I. G
Published: September 2020

The article reviews the results of a survey of healthcare professionals from different regions working with the children’s population. The survey included specialists working in the field of rehabilitation of children who underwent neuroinfections and other disorders of the nervous system, as well as specialists providing other types of medical care to the children. The survey was mainly attended by experienced specialists. Almost half of the respondents have a seniority of more than 20 years (47.0%). According to the results of the study, it was established that practically every fifth doctor (19.8%) does not know where the rehabilitation help to the children who underwent neuroinfections is provided. The weighty shares of experts point to the extreme urgency of such problems as the waiting time for the commencement of rehabilitation, the transportation of children to the rehabilitation site, the lack of modern medical equipment, the lack of doctors and nurses and other problems. 60.3% of the respondents indicated a significant shortage of specialists able to provide rehabilitation assistance to children who had undergone neuroinfections. One out of every five respondent (18.2%) pointed to the lack of growth in the quality of rehabilitation measures in their region. And 22.4% of specialists noted the lack of the gain in high-tech methods of rehabilitation of children in their region. An analysis of the responses of specialists made it possible to identify two main groups of problems to which management decisions should be directed. These groups include organizational and financial problems. All specialists point to the need to expand the network of medical institutions that provide rehabilitation to children who have undergone neuroinfections, as well as the need to introduce new rehabilitation techniques into practice.
COMPREHENSIVE STUDY OF DISABILITY DUE TO DIABETES MELLITUS IN THE RUSSIAN FEDERATION
Authors: Chikinova Larisa N. , Begma I. V , Zapariy N. S , Boltenko Zh. V
Published: September 2020

When analyzing the indices and the structure of the disability due to diabetes mellitus over the period of 2012-2016, a decrease in the number of diabetes mellitus patients both recognized as disabled for the first time (RDFT) and recognized as disabled repeatedly (RDR), reduction in the level of the primary and secondary disability due to diabetes mellitus, a predominance of group III invalids in the structure of the contingent of RDFT and RDR, but more than a third were invalids of the I and II disability groups, which determines the need for the development of comprehensive programs for the prevention of diabetes mellitus, rehabilitation of patients and people with disabilities with this pathology.
Oxidative stress in the pathogenesis of vitiligo and methods for its correction
Authors: Gereykhanova L. G , Lomonosov Konstantin M. , Bashlakova K. A
Published: September 2020

One of the most studied theories about pathogenesis of vitiligo, the theory of biochemical disorders, where oxidative stress plays an important role, is presented. Changes of intercellular antioxidative status in combination with epidermal cells indicate to part of the oxidative stress in pathogenesis of vitiligo and allow to effect on process offree radical oxidation. These positive effects of antioxidants in the treatment of vitiligo confirm the theory of oxidative stress. The biological properties of ozone, that has a direct effect on peroxidation and antioxidant defense system of vitiligo are described.
Sequencing methods in dermatology
Authors: Aksenenko Maria B. , Ruksha T. G
Published: September 2020

Review of the literature devoted to the application of sequencing methods (genome research method) at various dermatological diseases. DNA sequencing technology is described in the article. Sanger Sequencing Method and Next-Generation Sequencing are discussed. Examples of genes and mutations found by sequencing methods are presented. Clinical meaning of mutations in BRAF, NRAS, KIT, GNAQ, GNA11 genes that play an important role in the pathogenesis of different clinical pathological forms of melanoma is described. Reveling tumor subtypes provides a selective approach in treatment of cutaneous melanoma, that can be useful in different therapeutic methods and makes it possible to predict the development of chemoresistance. Furthermore, data about another genes, that play an important role in pathogenesis of different dermatological diseases with tumor and non-tumor genesis are presented.
Systemic lupus erytherymatosus: an interdisciplinary approach to the diagnosis
Authors: Tlish M. M , Naatyzh Zhanna Yu. , Sycheva N. L , Kuznetsova T. G , Irizelyan G. A , Psavok F. A
Published: September 2020

Diagnosis of systemic lupus erythematosus presents certain difficulties up to now. Due to the prognostic significance of the disease and the need to early pathogenetic treatment clinical cases of SLE are described. Questions of modern differential diagnosis are reviewed. If skin changes are presented a positive test for antinuclear antibodies helps to detect SLE timely. 4 clinical cases of women with systemic lupus erythematosus are presented. Diagnostics required comprehensive examination with histopathological and immunological studies: blood test antinuclear factor on HEp-2 cells with the definition of lupus anticoagulant in blood plasma, rheumatoid factor, anticardiolipin antibody IgG and IgM, double stranded DNA, antinuclear antibody IgG, auto antibodies to IgG AMA-M2 (immunoblott), cardiolipin antibodies and lupus anticoagulant.
Hidradenitis suppurativa: clinic and diagnostics (part 2)
Authors: Masyukova S. A , Mordovtseva V. V , Ilina Inna V. , Sanakoeva E. G , Alieva Z. A , Grebenyuk D. V , Gubanova E. I
Published: September 2020

The data on the clinical features and course of suppurative hidradenitis characterized by severe course and a tendency to relapse are presented. To select the treatment strategy the scale of the severity and staging process are proposed. The atypical localization of purulent suppurative hidradenitis and follicular occlusion tetrad, which also includes conglobata acne, folliculitis sycosiformis atrophicans / exfoliating scalp cellulitis and pilonidal abscess are described. It is proved that manifestation of suppurative hidradenitis are phenotypically heterogeneous. The role of genetic, comorbid factors, metabolic and hormonal disorders, as well as the role of the immune system in the development of the disease are discused. For the diagnosis index Sartorius (Sartorius score), microbiology, immunohistochemistry and other research methods, which largely determine the tactics of treatment of severe dermatosis were used.
Vitiligo treatment algorithm
Authors: Lomonosov Konstantin M. , Gereykhanova L. G
Published: September 2020

The treatment strategy ofpatients with vitiligo, including the identification of motivation for long-term treatment and informing patients to avoid false expectations as causes of dissatisfaction and early termination of the therapeutic course are described. The algorithm for the treatment of vitiligo consists of five successive stages. Each of them is sequentially applied with no previous treatment regimens efficiency or its maximum possible effect achievement. The use of the described treatment algorithm allows us to achieve in 70-80% of cases a marked repigmentation of vitiligo and to ensure long-term and often life-long remission of the disease.
Exceptional case of disseminated necrobiosis lipoidica similar to a sarcoidosis form at the child affected by diabetes type I
Authors: Bazaev V. T , Tseboeva M. B , Tsarueva M. S
Published: September 2020

The article describes the infrequent disseminated necrobiosis lipoidica similar to a sarcoidosis form which developed at the five-year-old child affected by type 1 diabetes mellitus. The short review concerns the questions of an etiology, pathogenesis, clinical forms, diagnostics and the modern methods of treatment of the described pathology. In the review 26 sources of literature are used. The case is of interest to dermatovenereologists, endocrinologists, pediatricians.
Differential diagnostic criteria of alopecia areata
Authors: Baltabaev A. M , Tkachev V. P , Baltabaev M. K
Published: September 2020

Alopecia areata is a poliethiologic immune mediated condition, associated with lesion of the hair follicles, leading to disruption of growing cycle and subsequent hair loss. Taking into account the different age of patients and repeated recurrence despite of the therapy, as well as changes in the appearance of the individual affecting psychosocial status, patchy hair loss refers to the category of socially important disorders. The introduction of computer technologies facilitated diagnostic approaches through developing of specific criteria for the diagnosis of alopecia areata, which improved its differentiation with similar dermatological conditions. This publication intended to review and analyze of clinical cases of several dermatological disorders which remind clinics of different forms of alopecia areata. The importance of trichoscopy was shown to provide differential diagnosis in various hair-loss conditions to evaluate morphometric hair and skin characteristics.
PEMPHIGUS AND PSYCHOSOMATIC DISORDERS: CLINICAL TYPOLOGY
Authors: Teplyuk N. P , Dorozhenok I. Yu , Katranova Daria G.
Published: September 2020

Psychosomatic disorders, comorbid with true acantholytic pemphigus (pemphigus) and identified clinical manifestations, the relationship of pemphigus with psychogenic disorders are described. Some patients had mental disorder (adjustment disorder) provoked by pemphigus - nozogenic reactions. In some patients with aberrant hypochondria iatrogenic (drug) hypomania was discovered on the high doses of systemic glucocorticoids. The Dermatоlоgy Index оf Disease Severity (DIDS) and The Dermatology Life Quality Index (DLQI) was calculated for all patients. According to the results of the study dissociation between the severity and the subjective perception of the disease with the help of these indicators was determined.
INNOVATIONS TO TOPICAL THERAPY OF ROSACEA
Authors: Olisova O. Yu , Kochergin N. G , Smirnova Elena A.
Published: September 2020

The main pathogenetic aspects of rosacea, various classifications of dermatosis and the modern clinical classification are presented. The symptoms that differentiate rosacea from other dermatoses are described. Contradictory of modern scientific concepts of different researchers, approaches to etiology, pathogenesis and treatment has been noted. The social significance of rosacea, the importance and possibility of eliminating the symptoms of the disease at early stages, the achievement and prolongation of remission are shown. The main triggers for the manifestation of rosacea, which should be taken into account to achieve the maximum effect in the treatment of the disease, are indicated. The domestic and foreign clinical recommendations on the treatment of the disease are considered in view of the appearance of new external drugs. The results of several studies in the USA and Canada on the efficacy of 1% ivermectin cream and 0.5% brimonidine tartrate gel compared to placebo are shown. The first domestic positive experience of self-study with 1% ivermectin cream (Solantra®) and 0.5% brimonidine tartrate gel (Mirvazo Derm®) is presented. The high efficacy and very good tolerability of this drugs, as well as the absence of any side effects in patients with moderate to severe rosacea are shown.
PSORIASIS ADJUVANT THERAPY
Authors: Bakulev Andrey L. , Krachevnya S. S , Igonina I. A , Galkina E. M , Utz S. R
Published: September 2020

60 adult patients with moderate severity of psoriasis in progression phase of dermatosis were observed. In the combined therapy of methotrexate and topical glucocorticosteroid, the patients were additionally treated with Cetaphil® Restoraderm™ Skin restoring moisturizing lotion (hereinafter referred to as Cetaphil® RestoradermTM moisturizing lotion). In the course of treatment a multivariate evaluation of the functional and morphological parameters of the skin using the SOFT PLUS TOP apparatus (sebumetry, corneometry and elastometry), as well as assessment of severity, prevalence of psoriasis (PASI), quality of life of patients (DLQI) on the 14th and 28th days of observation was performed. It was found that the inclusion of moisturizing lotion in the combined therapy led to an earlier beginning of stabilization and regression of the psoriatic process, relief of subjective disorders, improvement of the quality of life of patients with psoriasis. Also statistically significant reduction of skin dryness and normalization of moistness and elasticity, which testifies to the expressed sebouregulating, elastogenic and moisturizing effects of this topical remedy, were observed.
LIPOID NECROBIOSIS: A REVIEW
Authors: Smirnova L. M , Semenchak Yulia A. , Panchenko L. A
Published: September 2020

Necrobiosis lipoidica (syn.: skin disclipines, diabetic lipoid necrobiosis of Urbach, disease Oppenheim--Urbach, mottled atrophic necrobiosis diabetic dermatitis Oppenheim, pseudocertainty symmetrical chronic granulomatous disease Gottron, etc.) - is a chronic granulomatous disease characterized by multifactorial genesis in the background of immunological changes, disorders of carbohydrate and lipid metabolism and pathology of microcirculatory processes. This article presents a review of the current literature on the etiology and pathogenesis, clinical picture, classification, differential diagnosis of disease and on methods of conducting and treatment of patients.
MARKERS OF DAMAGE TO NERVOUS TISSUE IN LIQUOR PATIENTS WITH VARIOUS FORMS OF NEUROSYPHILIS
Authors: Novikov Yuriy A. , Ochlopkov V. A , Novoselov V. S , Kidalov M. B , Kravchenko E. N
Published: September 2020

The purpose: to study the features of markers of lesion of nervous tissue and cytokines in patients with various forms of neurosyphilis. Material and methods. The complex clinical examination of patients with syphilis was carried out in the venereological department of the Clinical dermatovenerologic dispensary in Omsk in the period from 2015 to 2017, in order to identify signs of damage to the nervous system. Results: the presence of regularities and features in the deviation of the immune status in neurosyphilis was found. Conclusion. Analysis of the immunological changes in the cerebrospinal fluid showed that the level of interleukin 12p40 is significantly higher in the cerebrospinal fluid of patients with neurosyphilis, while the maximum values of these indicators are in patients with manifest forms of pathology. In patients with neurosyphilis, the concentration of glial fibrillar acidic protein in CSF was statistically significantly increased then in comparison group.
INVASIVE METHODS OF TREATMENT OF VITILIGO
Authors: Melnikova Yulia G. , Lomonosov K. M , Gereykhanova L. G
Published: September 2020

The review of the literature is devoted to the use of various invasive treatments for a disease such as vitiligo. The article deals with the majority of methods of treating dermatosis with damage to the integrity of the skin from intraocular administration of corticosteroid preparations, immunomodulators to various methods of “surgical” intervention. Also, examples of techniques of micronidling and nidling with tacrolimus in combination with UVB are given. In addition, some data from one of the potentially effective methods in the treatment of this pathology-the use of platelet-enriched plasma are presented.