bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypothermia Does Not Result in More Complications after Colon Surgery
Authors: Barone James E. , Tucker James B. , Cecere John , Yoon Mi-Yung , Reinhard Elaine , Blabey Robert G. , Lowenfels Albert B.
Published: November 2022

Our objective was to determine the incidence of complications in postoperative patients who were either normothermic or hypothermic. A recent, widely publicized paper concluded that the maintenance of normothermia could reduce the incidence of infectious complications and shorten hospitalization in patients undergoing colorectal surgery. However, some controversy arose regarding the methods of this paper. Patients were deliberately rendered hypothermic, were given more than 3.5 days of prophylactic antibiotics and were transfused significantly more units of blood. We reviewed the charts of 150 consecutive patients who underwent elective partial or subtotal colectomy with primary anastomosis. Among the key items analyzed were intraoperative and postoperative temperature, use of warming devices, duration of surgery, transfusions, interval to oral intake and bowel function, length of stay, complications, infections, and laboratory values. Hypothermia was defined as intraoperative temperature <95.5° F. There were 101 normothermic patients and 49 hypothermic patients. Hypothermic patients had a mean age of 68.7 years versus 66.8 for the normothermic patients (P = 0.472). Comorbidities were similar in both groups. Warming devices were used in >90 per cent of the patients in both groups. The rates of postoperative infections and complications were similar in both groups. Postoperative lengths of stay were also not different. Despite finding that one-third of our patients were hypothermic during elective colon resection, hypothermia had no effect on outcome variables. In contrast to the previous study, the incidence of infectious complications was identical in our patients. Before ascribing postoperative complications and increased resource utilization as adverse effects of hypothermia, further studies are indicated.
Prevention of Adhesions to Polypropylene Mesh in a Rabbit Model
Authors: Dinsmore Robert C. , Calton William C.
Published: November 2022

The purpose of this study was to develop a quantitative model for evaluating adhesion formation and to determine whether Seprafilm (HAL-F) bioresorbable membrane (Genzyme Corp., Cambridge, MA) is effective in preventing adhesions to polypropylene mesh (PPM). PPM has been shown to be an effective material for the repair of abdominal wall defects. One disadvantage of PPM is its tendency to form dense adhesions when in contact with abdominal viscera. HAL-F, a sodium hyaluronate/carboxymethylcellulose absorbable membrane, has been shown to prevent adhesion formation after midline closures. Its efficacy in preventing adhesions to PPM has not been examined previously. A 5 x 7-cm anterior abdominal wall defect was created in 24 New Zealand White rabbits. This defect was then repaired with PPM. In the experimental group, a 5 x 7-cm piece of HAL-F was placed between the mesh and the abdominal viscera. At 30 days, the animals were killed and adhesions were categorized and quantified using digital image analysis of inked specimens. The strength of mesh incorporation into surrounding tissues was also examined using an Instron tensiometer. The formation of adhesions between the viscera and mesh repair was significantly reduced by the use of HAL-F. The surface area involved for bowel adhesions was reduced 94 per cent (P = 0.00132). The strength of incorporation was not adversely affected. HAL-F is highly effective in preventing adhesions to PPM, without adversely effecting the strength of mesh incorporation.
Obstructive Jaundice Caused by Tumor Emboli from Hepatocellular Carcinoma
Authors: Hu Jixiong , Pi Zhiming , Yu May Ying , Li Yongguo , Xiong Shouzhi
Published: November 2022

Hepatocellular carcinoma (HCC) presenting as obstructive jaundice due to intrabile duct tumor growth is being reported with increasing frequency. We describe our clinical experiences and evaluate the results of different operative procedures for this disease. A retrospective study was undertaken to review 18 patients with obstructive jaundice by tumor emboli from HCC during a 15-year period of time. We reviewed clinical features, types of operative procedures, operative findings, and survival in the patients. All patients on initial examination had recurrent episodic jaundice or cholangitis. Types of surgical procedures were choledochotomy with T-tube drainage alone in nine patients, choledochotomy with T-tube drainage followed by hepatectomy in six, and T-tube drainage followed by transcatheter hepatic arterial chemoembolization in the remaining three patients. Liver cirrhosis was the associated disease in 15 (83.3%). There were three postoperative deaths (16.7%). The mean survival time for nine patients with external drainage alone was 4.5 months. For the three patients with T-tube drainage and transcatheter hepatic arterial chemoembolization, mean survival time was 11 months. Six patients who had undergone hepatectomy had a better postoperative survival time, with 1 surviving for more than 3 years and another alive for 70 months, without evidence of recurrence at the moment. Jaundice is not necessarily a harbinger of advanced disease and a contraindication for surgery. Managed properly, these patients will have satisfactory palliation and occasional cure.
Can Oral Metronidazole Substitute Parenteral Drug Therapy in Acute Appendicitis?: A New Policy in the Management of Simple or Complicated Appendicitis with Localized Peritonitis: A Randomized Controlled Clinical Trial
Authors: Banani S. Abbas , Talei Abdolrasool
Published: November 2022

To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21.38).

The patients were randomly divided into two groups. The study group (SG) (524 patients) received OM (500 mg for adults, 7–10 mg/kg if less than 15 years) 2–3 hours before operation. The drug was continued 4 to 5 hours after operation, every 8 hours, for three doses if the appendix was mild to severely inflamed. In the case of complicated appendicitis (114 patients), the same dose was given for 3 to 6 days, depending on the absence or presence of pus. Ceftizoxime was administered to the control group (CG) (559 patients) 2 to 3 hours before operation and then postoperatively every 6 hours for three doses if the appendix was mild to severely inflamed. The complicated cases in the CG (120 patients) received a combination of penicillin, chloramphenicol, and gentamicin for 3 to 6 days, depending on the absence or presence of pus.

The serum concentration of metronidazole measured in 43 patients was at bactericidal level in 40 (mean ± SD standard deviation, 10.65 ± 4.89 μg/mL).

The rate of wound infection was not significantly different in the SG and the CG with the same degree of pathology (3.17% vs 2.96% if uncomplicated; 15.78% vs 14.16% if complicated, respectively). Pelvic collection occurred in four adults and one child in the CG with perforated appendicitis (4.16%). The same complication developed in two adults and two children in the SG with perforated appendicitis (3.5%). All six adults and one of the children in the SG had to be re-explored, whereas the remaining two children responded to conservative management (OM and gentamicin). In uncomplicated cases, hospital stay and hospital charge were both almost the same in both groups. However, length of hospitalization was nearly 1 day shorter and hospital cost per day was about 30 per cent less in complicated cases in the SG as compared with the CG.

Conclusively, OM may not only substitute parenteral antibiotics in acute appendicitis as a prophylactic agent, but it may also be used as a cost-effective drug and is more convenient to the patient.
Use of Venous Duplex Scans to Evaluate Symptoms of Deep Vein Thrombosis: An Analysis of Ultrasound Usage by Various Medical Specialties
Authors: Mccoy Kelly L. , Gahtan Vivian , Kerstein Morris D.
Published: November 2022

In today's environment of cost-containment and utilization management, duplex ultrasound is often overused to evaluate symptoms of deep venous thrombosis/thrombophlebitis (DVT), reflecting the low diagnostic yield of such studies. We investigated the use of venous duplex scans by various medical specialties to determine whether a tendency exists to overuse this diagnostic tool by one specialty compared with others and to assess the cost-effectiveness of ordering this test for acute venous disease changes. We retrospectively reviewed the results of venous duplex ultrasound studies for 330 consecutive patients with suspected DVT for a 1-year period. Our analysis showed that 51 of 330 (16%) of all duplex scans ordered in our institution were positive for DVT. Internists, as a group, ordered 185 studies of which 26 were positive (14%). The surgeons’ requests for duplex studies resulted in 23 of 137 (17%) confirmed positive studies. The overall positive examination rate was 16 per cent, which is not only suboptimal as a diagnostic tool, but also cumbersome with regard to health care cost-containment.
Markers of Severe Appendicitis
Authors: Tehrani Hassan Y. , Petros James G. , Kumar R. Ravi , Chu Quyen
Published: November 2022

Appendicitis is a common surgical disease that often presents with vague, inconclusive symptoms. Despite the development of technologically advanced diagnostic modalities, perforation has usually occurred before the surgeon sees the patient. Morbidity, length of stay, and hospital costs associated with appendiceal perforation have not changed markedly in the past 50 years. To evaluate prognostic markers for severe appendicitis, we reviewed 18 years’ worth of records of patients with appendicitis who were admitted to St. Elizabeth's Medical Center of Boston and found that the combination of history and physical examination has withstood the test of time. We found that advancing age, duration of symptoms for 36 or more hours, white blood cell count, shift left in white blood cell count, and fever were significantly related to severe appendicitis. An abnormal plain film was a marker if fever coexisted.
Acantholytic Variant of Squamous Cell Carcinoma of the Breast: A Case Report
Authors: Parramore Brant , Hanly Mark , Yeh Karen A. , Mcneely Timothy
Published: November 2022

Primary squamous cell carcinoma of the breast is a rare clinical entity. Two large review series found only five cases out of a total of 8351 breast malignancies. This case report presents a patient with metaplastic, pseudoangiosarcomatous carcinoma or acantholytic variant of a squamous cell carcinoma of the breast. This diagnosis was based on the histological finding of highly atypical, acantholytic squamous cells. Because the tumor stained positive for keratin and negative for factor VIII, the diagnosis of angiosarcoma was ruled out. Although only scattered case reports have been published on this histological variant, these tumors tend to follow an aggressive course.
Antioxidant Therapy in the Prevention of Organ Dysfunction Syndrome and Infectious Complications after Trauma: Early Results of a Prospective Randomized Study
Authors: Porter John M. , Ivatury Rao R. , Azimuddin K. , Swami Raj
Published: November 2022

Reactive oxygen species have been implicated in the etiology of multiorgan dysfunction syndrome and infectious complications in trauma patients by either direct cellular toxicity and/or the activation of intracellular signaling pathways. Studies have shown that the antioxidant defenses of the body are decreased in trauma patients; these include glutathione, for which N-acetylcysteine is a precursor, and selenium, which is a cofactor for glutathione. Eighteen trauma patients were prospectively randomized to a control or antioxidant group where they received N-acetylcysteine, selenium, and vitamins C and E for 7 days. As compared with the controls, the antioxidant group showed fewer infectious complications (8 versus 18) and fewer organs dysfunctioning (0 versus 9). There were no deaths in either group. We conclude that these preliminary data may support a role for the use of this antioxidant mixture to decrease the incidence of multiorgan dysfunction syndrome and infectious complications in the severely injured patient. This remains to be confirmed in larger trials.
Mediastinal Evaluation Utilizing the Reverse Trendelenburg Radiograph
Authors: Barker Donald E. , Crabtree J. Dennie , White James E. , Somberg Lewis B. , Burns R. Phillip
Published: November 2022

When thoracic aortic rupture is suspected, a 45-degree reverse Trendelenburg (RT) anteroposterior (AP) chest radiograph should place the mediastinal structures in a more appropriate position and allow a more accurate evaluation than a supine AP radiograph. One hundred ninety-one consecutive hemo-dynamically stable adult patients with major blunt thoracic trauma were initially evaluated for mediastinal abnormalities associated with aortic disruption by both supine AP chest radiograph and an AP chest radiograph with the patient in 45-degree RT position. One hundred four patients underwent contrast aortography based on mediastinal abnormalities detected on the supine AP chest radiograph. Twenty of these patients had abnormal aortograms demonstrating traumatic aortic disruption confirmed at surgery. Supine and RT chest radiographs were retrospectively compared in a blinded fashion to evaluate their specificity and positive predictive value for detection of traumatic thoracic aortic rupture. If RT chest radiographic findings had been used to determine the need for further assessment, 29 angiograms (26%) would have been eliminated, specificity would have increased from 52 per cent to 69 per cent, and positive predictive value would have increased from 19 per cent to 27 per cent. Both supine and RT chest radiographs demonstrated mediastinal widening in all 20 patients with abnormal aortograms, with no missed thoracic aortic disruptions (100% sensitivity). This study indicated that the RT chest radiograph may be used instead of the standard supine radiograph as the initial screen for mediastinal evaluation, maintaining a high sensitivity and eliminating the cost and morbidity of many unnecessary aortograms.
The Pitfalls of Establishing a Statewide Vascular Registry: The South Carolina Experience
Authors: Taylor Spence M. , Robison Jacob G. , Langan Eugene M. , Crane Martin M.
Published: November 2022

Concerned about the inadequacy of a centralized database and the importance of low morbidity and mortality on carotid endarterectomy efficacy, the South Carolina Vascular Surgical Society prospectively instituted a computer registry for carotid procedures performed by its members, to establish a statewide standard of practice. From January 1994 through December 1997, 23 of the 30 physician members voluntarily registered data on 1652 carotid operations at 14 hospitals into a central database. Blinded results were reviewed biannually. Complete data (1995–1997) were available for 1199 cases. The patients tended to be >64 years old (72%), male (62%), and white (93%). Carotid endarterectomy was the most frequently performed operation (90%). Perioperative complications (≤30 days) occurred in 173 patients (14.4%), including stroke (n = 19; 1.6%), death (n = 8; 0.7%), and stroke/death (n = 25; 2.0%). Although 23 surgeons (77% of the society) contributed some data, only 10 surgeons (33%) contributed complete data on >10 patients/year. Despite biannual efforts to boost participation, case entry remained stable (1994, 358; 1995, 347; 1996, 425; and 1997, 427), representing about one-third of the estimated carotid procedures performed in the state during that period. The cost of the registry was approximately $11,500. Audit of 8 surgeons revealed a >95 per cent match against the statewide discharge database and low error rate versus independent medical record review. This experience confirms that excellent outcomes after carotid endarterectomy are not limited to a few select centers and can be accomplished by adequately trained surgeons in a variety of institutional settings. Incomplete physician participation, however, inevitably raises questions about the utility of such efforts. Until volunteer registries induce full participation by heightening perceived physician benefit, their role will remain limited for future outcomes research.
The Effect of Peritoneal Contamination on Wound Strength of Small Bowel and Colonic Anastomoses
Authors: Orlando Marc D. , Chendrasekhar Akella , Bundz Samuel , Burt E. T. , Moorman Donald W. , Timberlake Gregory A.
Published: November 2022

Primary bowel repair in the face of peritoneal soilage is still a controversial area. Previous studies using the rat model have demonstrated a difference in new collagen synthesis after 24 hours of peritoneal contamination. Currently, the effect of short-term fecal contamination of the peritoneal cavity on anastomotic healing and strength is not known. This study was designed to evaluate anastomotic wound strength in the face of fecal contamination during this time period. Twenty Sprague Dawley rats were randomized into two groups: twelve-hour control (n = 10) and 12-hour cecal ligation and puncture (CLP; n = 10). Both groups underwent laparotomy with either CLP (12-hour) or cecal manipulation (12-hour control). Animals were allowed to recover for 12 hours, according to their assigned groups. A second laparotomy was subsequently performed in which the CLP groups had partial cecectomy to remove the source of contamination, followed by mid-jejunal and colonic division with associated primary anastomosis. Control groups had a similar procedure without partial cecectomy. All abdomens were irrigated, and all animals received immediate postoperative antibiotics and an initial fluid bolus. Animals were recovered and received 3 days of postoperative antibiotics. On postoperative day 4, animals were sacrificed and anastomotic sites were resected. Specimens were then placed in a tensiometer and disrupted under dynamic stress. Peak load was recorded for each, and maximum standard load was calculated. Hydroxyproline content of each segment was also determined after disruption. CLP values were compared with control values using unpaired Student's t test. Statistical significance threshold was P < 0.5. There was no significant difference in maximum anastomotic wound strength or hydroxyproline content between 12-hour CLP and 12-hour control group for both small bowel and colon anastomoses. Short-term peritoneal soilage (12-hour) does not significantly effect the maximum tensile strength or hydroxyproline content of primary small bowel or colonic anastomoses in this model. This study suggests that short-term fecal contamination of the peritoneal cavity may not be a contraindication to primary bowel anastomosis.
Stab Wounds to the Back/Flank in Hemodynamically Stable Patients: Evaluation using Triple-Contrast Computed Tomography
Authors: Albrecht Roxie M. , Vigil Anthony , Schermer Carol R. , Demarest Gerald B. , Davis Victor H. , Fry Donald E.
Published: November 2022

Triple-contrast computerized tomography OCT) has been proposed as a method to detect high-risk injuries in hemodynamically stable patients with stab wounds (SWs) to the back/flank and to successfully triage patients with low-risk scans into a potentially cost-effective treatment algorithm. The purpose of this study was to retrospectively review our experience with the use of 3CT for diagnostic accuracy of SWs to the back/flank and to evaluate potential decreased length of stay (LOS) in the hospital for patients with low-risk scans and no associated injuries. Seventy-nine hemodynamically stable patients met criteria for inclusion in this review. Fifty-eight 3CTs were performed for initial evaluation, 44 low risk and 14 high risk, and 21 patients underwent mandatory laparotomy. The accuracy of 3CT was found to be 97.9 per cent. The LOS was significantly less in patients who had no associated injuries and a low-risk 3CT (16.5 hours), as compared with all other treatment groups. Hemodynamically stable patients with SWs to the back/flank may be safely triaged using 3CT. Patients with low-risk scans and no associated injuries may be discharged immediately, and those with potential delayed associated injuries should be observed for 6 to 24 hours. This strategy significantly decreases LOS in patients with low incidence of significant injury.
Diagnosis of Blunt Rupture of the Right Hemidiaphragm by Technetium Scan
Authors: May Addison K. , Moore Marcia M.
Published: November 2022

Traumatic rupture of the diaphragm, particularly of the right hemidiaphragm, may be occult and can be difficult to diagnose if laparotomy is not required for concomitant injury. Missed or delayed diagnosis of such injuries can produce life-threatening complications, such as intestinal herniation, ischemia, and necrosis. We present a case of traumatic rupture of the right hemidiaphragm that demonstrates the typically occult nature of this injury. The majority of right-sided injuries are diagnosed during laparotomy performed for other injuries. In those patients not requiring laparotomy, the diagnosis is usually delayed because this injury seldom produces clinical or radiographic findings that are either sensitive or specific. In this case, intraperitoneal injection of technetium sulfur colloid was used to establish the diagnosis of right diaphragm rupture, and an uncomplicated repair was undertaken.
Primary Hepatic Lymphoma in Hepatitis C: Case Report and Review of the Literature
Authors: Chowla Arun , Malhi-Chowla Navreet , Chidambaram Arul , Surick Burton
Published: November 2022

Primary B-cell lymphoma of the liver is an extremely rare tumor. The higher incidence of hepatocellular carcinoma in hepatitis C is well known, but the relationship with lymphoma is unclear. An increased incidence has been reported in patients with chronic hepatitis C. Hepatitis C virus is known to be a lymphotropic virus. Mixed cryoglobulinemia, which is a benign lymphoproliferative disorder, has a definite association with hepatitis C. It is postulated that the virus may also induce a malignant transformation. We describe an unusual presentation of a case of asymptomatic left hepatic mass in a patient with hepatitis C with a preoperative diagnosis of hepatocellular carcinoma. He underwent a left lateral segmentectomy, and the pathologic examination revealed non-Hodgkin's lymphoma. The clinical features, radiologic investigations, and pathologic findings are presented. A review of the literature discussing clinical features, postulated pathogenetic mechanisms, and management options is also presented.
Signet Ring Cell Histology is Associated with Unique Clinical Features but Does Not Affect Gastric Cancer Survival
Authors: Theuer Charles P. , Nastanski Frank , Brewster Wendy R. , Butler John A. , Anton-Culver Hoda
Published: November 2022

Signet ring cell histology is found in 3 to 39 per cent of gastric cancer cases and has been reported to be a feature of poor prognosis, although this issue has not been rigorously examined. The objective of this study was to determine those demographic and clinical variables associated with signet ring cell histology and to determine the effect of signet ring cell histology on survival using multivariate analyses. We studied a historical cohort of consecutive cases of gastric cancer reported to the population-based California Cancer Registries of Orange, San Diego, and Imperial Counties from 1984 through 1994. Factors associated with signet ring cell histology were assessed using χ2 and logistic regression. Life tables were constructed to assess unadjusted survival and survival differences in patient subgroups. Multivariate survival was determined using a Cox proportional hazards model. Of 3020 patients, 464 (15%) had signet ring cell histology. Patients with signet ring cell histology were more likely to be younger than 50 years (odds ratio (OR) = 2.4; 95% confidence interval (CI) = 1.6–3.5), less likely to be male (OR = 0.49; 95% CI = 0.37–0.66), and more likely to have tumors of the distal stomach (OR = 2.0; 95% CI = 1.4–3.0). Signet ring cell histology did not adversely affect unadjusted overall survival, race-stratified survival, or stage-stratified survival. Multivariate analysis indicated that patients with signet ring cell histology had an insignificant increased risk of dying (relative risk = 1.027; P > 0.10) in comparison with patients without signet ring cell histology. Patients with signet ring cell histology were more likely to be young women and to have tumors of the distal stomach. Signet ring cell histology did not impact survival in our group of largely advanced gastric cancer cases.
The Utility and Reliability of Computed Tomography Scan in the Diagnosis of Small Bowel Obstruction
Authors: Daneshmand Siamak , Hedley Christopher G. , Stain Steven C.
Published: November 2022

Accurate diagnosis and treatment of small bowel obstruction (SBO) is critical to prevent complications and reduce costs. The purpose of the current study was to evaluate the evolving role of CT scan for patients with suspected SBO and compare its sensitivity and specificity with plain abdominal films. We identified 108 patients over a 1-year period with an admission or discharge diagnosis of SBO. Five patients treated on a clinical basis without radiographic imaging and those with indeterminate films were excluded from analysis. CT and radiograph reports were compared with operative findings or clinical course in 103 patients. By the clinical course, 66 of the patients had a partial or complete SBO. Plain film radiography correctly established the diagnosis of SBO in 50 of 66 patients (sensitivity, 75%). Nine of 17 plain films were true negatives (specificity, 53%). CT was able to correctly identify partial or complete SBO in 35 of 38 patients (sensitivity, 92%) and correctly identified the lack of obstruction in 8 of 13 patients (specificity, 71%). These data document that plain films are a less sensitive and less specific method of diagnosing SBO and confirm that the use of CT scan is a valuable modality. CT scan should be considered for use as the primary test for patients with suspected SBO.
Pressure Control Inverse Ratio Ventilation in the Treatment of Adult Respiratory Distress Syndrome in Patients with Blunt Chest Trauma
Authors: Mccarthy Mary C. , Cline Amy L. , Lemmon Gary W. , Peoples James B.
Published: November 2022

The objective of this study was to evaluate the efficacy of pressure control inverse ratio ventilation (PCIRV) in improving oxygenation in trauma patients with adult respiratory distress syndrome (ARDS) and to assess the potential risks associated with this form of treatment. This was a cohort study assessing the trends in hemodynamic and ventilatory parameters after the initiation of PCIRV, conducted at a community Level I trauma center intensive care unit. The study comprised 15 trauma patients developing severe, progressive ARDS [two or more of the following criteria: positive end-expiratory pressure (PEEP) >10 cm H2O; arterial partial pressure of oxygen divided by fraction of inspired oxygen (PaO2:FiO2) ratio <150; and peak inspiratory pressure (PIP) >45 cm H2O]: ten due to blunt chest injuries, three due to sepsis, and two due to fat emboli syndrome. PCIRV was initiated. Main outcome measures were PIP, PEEP (total, auto), oxygen saturation, cardiac index, oxygen delivery, PaO2:FiO2 ratio, compliance, evidence of complications of PCIRV, and mortality. Within 24 hours of conversion to PCIRV, the patients stabilized and the mean PaO2:FiO2 ratio rose from 96.3 ± 57.8 to 146.8 ± 91.1 (P < 0.05) and PIP fell from 47.9 ± 13.8 to 38.8 ± 8.4 cm H2O; auto-PEEP increased from 0.5 ± 1.9 to 7.5 ± 5.6 cm H2O (P < 0.05); oxygen delivery index remained stable (563 ± 152 to 497 ± 175 mL/min/m2); three patients developed evidence of barotrauma, one patient developed critical illness polyneuropathy, and two patients died (13%). PCIRV is an effective salvage mode of ventilation in patients with severe ARDS, but it is not without complications. Auto-PEEP levels and cardiac index should be monitored to ensure tissue oxygen delivery is maintained.
Pancreaticoduodenectomy for Ampullary Carcinoma
Authors: Roberts R. H. , Krige J. E. J. , Bornman P. C. , Terblanche J.
Published: November 2022

Thirty-two consecutive patients with adenocarcinoma of the ampulla of Vater who had curative resection by pancreaticoduodenectomy were analyzed to determine the accuracy of preoperative investigations and factors that influenced survival. Obstructive jaundice was present in 31 patients, and most patients had pain and weight loss. Ultrasound was more useful than CT in identifying biliary obstruction, whereas CT was more accurate in demonstrating pancreatic duct dilatation and an ampullary mass. Endoscopic retrograde cholangiopancreatography with biopsy and brush cytology was the most accurate investigation and proved or was suspicious of carcinoma in all patients. Nineteen patients had postoperative complications, three of whom died (9.4%)—two of sepsis and one from aspiration following hematemesis. Actuarial 5-year survival was 46 per cent. Stage of disease was the strongest predictor of survival. All patients with T1 lesions are alive more than 5 years after resection. Patients with lymph node metastases had a significantly shorter survival than node-negative patients (P = 0.00087). Pancreaticoduodenectomy is advocated for ampullary carcinoma in good-risk patients, with the anticipation of prolonged survival in those with early (T1) lesions and node-negative disease.
Acute Calf Vein Thrombosis: Outcomes and Implications
Authors: Kazmers Andris , Groehn Harvey , Meeker Chris
Published: November 2022

The purpose of this study was to define the incidence of and outcomes associated with isolated acute calf vein thrombosis (CVT). From 11/95 through 6/97, 3096 patients underwent lower extremity venous duplex testing in a hospital-based vascular laboratory in which bilateral tibial and peroneal vein imaging were standard components of the venous duplex examination. CVT was present in 118 patients (3.8%), and 339 patients (10.9%) had acute proximal deep venous thrombosis (PDVT). Patients with CVT were 56.4 ± 17.2 years of age (range, 18–92). Approximately 25 per cent with CVT had cancer (n = 30). Of the 18 patients with CVT who underwent ventilation-perfusion (V/Q) lung scanning, 56 per cent (n = 10) had high-probability scans. Venous duplex reports for those with CVT recommended follow-up venous duplex examination, which was done in 60 per cent (n = 71) of patients. Of the 71 patients with CVT who underwent follow-up testing, 15.5 per cent (n = 11) progressed to PDVT. The incidence of progression to deep venous thrombosis was 25 per cent (9 of 36) in those receiving anticoagulants at the time of initial venous duplex examination versus 5.7 per cent (2 of 35) in those not receiving anticoagulants (P = 0.046). With progression to PDVT, patients were more likely to have cancer (35% versus 7.8%; P = 0.009), more likely to have high-probability V/Q scans (36% versus 6.7%; P = 0.017), and more likely to die (27% versus 1.7%; P = 0.011) during follow-up. CVT was less common than proximal deep vein thrombosis and was also associated with pulmonary embolism. Progression of CVT was an adverse clinical event associated with greater chance of pulmonary embolism and death.
Adenocarcinoma of the Head of the Pancreas: Effects of Surgical and Nonsurgical Therapy on Survival—A Ten-Year Experience
Authors: Carr John Alfred , Ajlouni Munther , Wollner Ira , Wong Dominic , Velanovich Vic
Published: November 2022

A retrospective analysis of all patients treated for adenocarcinoma of the head of the pancreas from 1989 to 1998 was performed. Excluded were cancers in the body and tail, cystic neoplasms, ampullary tumors, and cancers of the duodenum and bile ducts. One hundred forty-five patients were reviewed, and 43 patients underwent pancreaticoduodenectomy. Data collected included the stage, lymph node status, surgical margins, adjuvant therapies, and survival. Statistical analysis was performed with Cox's Proportional Hazards Analysis and Log-Rank Life Table Analysis. The surgical population had a 21 per cent 3-year survival rate and a 7 per cent operative mortality rate. Median survival was: 1) the resection group versus no resection was 13.5 versus 3.1 months; 2) adjuvant therapy versus no therapy after resection was 16.1 versus 5.1 months; and 3) chemoradiation therapy versus no therapy for unresectable disease was 5.3 versus 1.8 months. The presence of positive surgical margins was found in 33 per cent of the surgical specimens and carried an increased mortality hazard ratio of 3.1. Patients with negative lymph nodes had a 15 per cent 5-year survival, versus 0 per cent with positive nodes. Seventy-three per cent of those resected had a T2 lesion, and 46 per cent of patients presented with metastatic disease. Surgical resection and adjuvant therapy significantly improves survival in patients with adenocarcinoma of the head of the pancreas. All patients who underwent resection as part of their therapy showed extended survival compared with chemoradiation therapy alone. Adjuvant chemoradiation improved survival when compared with surgery alone. Multimodality treatment in carcinoma of the head of the pancreas provides the best treatment option. However, better adjuvant therapies are needed.
Current Role of Scapulectomy
Authors: Rodriguez Jaime A. , Craven James E. , Heinrich Stephen , Wilson Scott , Levine Edward A.
Published: November 2022

Tumors of the scapula are an unusual clinical challenge. Partial or complete resection of the scapula, with its attached musculoaponeurotic tissue, is a seldom used technique for the treatment of primary bone and soft tissue tumors, as well as selected metastatic involvement of the scapula. Scapulectomy may allow wide margins of resection without amputation. The purpose of this study is to review our recent experience with scapulectomy. This study describes the recent experience with scapulectomy by the Section of Surgical Oncology and the Department of Orthopedics at Louisiana State Medical Center (New Orleans, LA). Between 1994 and 1998, 12 patients (between 16 and 79 years of age) underwent a resection of the scapula. Eleven of these patients had soft tissue tumors; one had a metastasis from a thyroid carcinoma. Six of these patients underwent a scapulectomy as a primary treatment, five for recurrence. Six patients also received postoperative radiation and/or chemotherapy. The follow-up ranged from 6 months to 4 years. There was no mortality or wound infection associated with scapulectomy. All patients had normal hand and wrist function after surgery. Three distant recurrences occurred, with no local or regional failures encountered during the follow-up period. Scapulectomy can result in excellent local tumor control. Whereas some loss of active shoulder motion may occur, hand, wrist and elbow function is preserved. Although maintenance of shoulder function should not take precedence over adequacy of resection, scapulectomy remains an excellent procedure for malignant disease that preserves hand, wrist, and elbow function.
Twisted and coiled yarns for energy harvesting and storage, artificial muscles, refrigeration, and sensing
Authors: Wang Zhong , Baughman Ray H
Published: November 2022

This overview focuses on our teams work on using twisted yarns and highly elastic coiled yarns for artificial muscles, energy harvesting, energy storage, sensing, and refrigeration. Despite the diversity of these applications for coiled carbon nanotube and polymer yarns, similar fabrication methods are applicable and conversion of coiling twist to yarn twist results in yarn elasticity, actuation, twistocaloric cooling, and the capacitance changes used for energy harvesting and sensing. Likewise, the same biscrolling method yields coiled yarns containing up to 95 weight percent of guest powders that provide various new properties. The obtained performance of the coiled polymer and carbon nanotube yarns are remarkable, such as artificial muscles that generate up to 98 times the output mechanical power than the maximum for the same weight human muscle and mechanical energy harvesters providing a higher peak electrical power per weight than prior art material-based mechanical energy harvesters for stretch frequencies between a few Hz and 600 Hz.
Rethinking Gregory of Nyssa’s Mystical Theology: The Role of Hostile Powers in Homilies on the Song of Songs
Authors: Thomas Gabrielle
Published: November 2022

The aim of this article is to rethink the way scholarship conceives Gregory of Nyssa’s so-called mystical theology by directing attention to his account of hostile powers in the Homilies on the Song of Songs. In recent decades, debates on “divine darkness” have governed scholarly readings of Christian progress in the homilies. However, through his allegorical commentary, Gregory also provides an extensive account of the history, ontology, and activity of the devil and demons, while also instructing Christians on how to defeat them. According to this account, only Christ is victorious in the proper sense. Therefore, believers must participate in Christ’s victory by journeying the way of the Homilies on the Song of Songs. This begins with baptism and continues with self-knowing, prayer, pure thoughts, and correct worship. Therefore, these homilies—communicating Gregory’s vision of “divine darkness”—also provide an extensive account of how to overcome adversarial powers whose goal is to prevent the bride’s union with God.
A systematic literature review on hybrid energy system
Authors: Das Uttara , Nandi Champa , Mandal Sarbani , Bhattacharjee Somudeep
Published: November 2022

Generation of energy has to increase due to society's demand escalation. However, generation from conventional sources is one of the major reasons for greenhouse gas emission, which is a key reason for global warming and climate change issues. To mitigate the emission of greenhouse gas and to protect the environment from pollution, renewable energy sources (RESs) are the one and only effective solution till date. To reduce the fluctuation of RESs on energy generation, a RES-based hybrid system is an innocuous solution. Here, a brief discussion of hybrid systems and their opportunities are presented and reviewed the role of the different combinations of renewable energy-based hybrid systems to reduce environmental pollution, generation costs, improve efficiency, and achieve a continuous power output of the system. A discussion is made on the importance of the site selection and the importance of different kinds of storage systems for energy generation. Result of article gives a brief idea regarding different factors to design future hybrid energy system (HES).
Perspectives on deep learning for near-infrared spectral data modelling
Authors: Passos Dário , Mishra Puneet
Published: November 2022

Deep learning for near-infrared spectral data is a recent topic of interest for near-infrared practitioners. In recent years, applications of deep learning are flourishing from analyses of point spectrometer data to hyperspectral image analysis. However, there are also some cases where simple partial least-squares based models are sufficient. This paper provides a concise view of the state of the art of deep learning for near-infrared data modelling, particularly discussing when deep learning is useful. Discussion is also provided on what is already achieved and what ideas would be interesting to pursue regarding deep learning modelling of near-infrared data.
Orthodontic Retainers and the Stability of the Maxillary Arch in Unilateral Cleft lip and Palate Patients: A Systematic Review
Authors: dos Santos Cibelle Cristina Oliveira , Bastos Renata Travassos da Rosa Moreira , Normando David
Published: November 2022

Objective

The aim of this systematic review was to elucidate the role of orthodontic retainers on the stability of compensatory orthodontic treatment in patients with unilateral cleft lip and palate.

Methods

Five electronic databases (PubMed, Scopus, Web of Science, LILACS, and LIVIVO) and the grey literature (OpenGrey and Google Scholar) were investigated, according to the population, exposure, comparator, outcomes and Study design eligibility criterion. The risk of bias assessment was determined based on the Risk of Bias In Nonrandomized Studies of Exposure (ROBINS-E) and the level of evidence with the GRADE tool.

Results

Three studies were included: two presented moderate risk of bias and one high. A moderate level of evidence revealed a mean value of 0.6 mm of intercanine relapse distance, and great variability between the data, regardless of the use or type of retention or rehabilitation. Relapse in the posterior region showed clinical significance, from −1 to −1.7 mm, especially in individuals who did not use retention, except in patients with symmetrical arches with Hawley retainer, where this value varies from −0.2 ± 0.63 mm.

Conclusions

Orthodontic retainers do not seem essential to prevent relapse at anterior maxillary dimensions after compensatory orthodontic treatment in patients with unilateral cleft lip and palate. Relapse in the posterior region can achieve greater clinical significance, which highlights the need for prolonged use of Hawley retainers and periodic evaluation of the stability of treatment results. Prospective studies with a longer follow-up can improve the certainty of the evidence.
Goltz Syndrome Combined with Triple X Syndrome, a Case Report
Authors: Sone Itaru , Honda Takayuki , Sakuraba Minoru , Satoh Kazuro , Kuwajima Yukinori , Baba Shunsuke , Wada Yasunori
Published: November 2022

Goltz syndrome is a rare X-linked dominant multisystem disorder that presents with ectoderm and mesoderm-derived symptoms. Skin manifestations including congenital patchy skin aplasia, congenital nodular fat herniation, congenital hypo- or hyperpigmentation along Blaschko's lines, telangiectasia, and congenital ridged dysplastic nails are typical in this disorder. Almost all cases of Goltz syndrome correspond to female newborns and that hemizygosis makes the syndrome fetal in males. Triple X syndrome is a relatively common congenital disorder that presents with mild to no symptoms in the developmental and psychiatric realm. The patient reported here was born with multisystem anomaly affecting the eyes, craniofacial region, cardiovascular system, skin, and limbs. A G-banding chromosomal study revealed 47, XXX. She was diagnosed with Goltz syndrome owing to her distinctive skin manifestations. The congenital cervical skin defect healed with conservative treatment. The facial cleft, cleft lip-palate, and syndactyly were successfully treated with multiple surgical treatments. The combination of triple X syndrome and Goltz syndrome is very rare. We describe the expression of presenting with both syndromes simultaneously.
Olfactory Reference Syndrome Treated With Lurasidone and Cognitive Behavioral Therapy: A Case Report
Authors: Das Soumitra , Sekharan Lokesh , Prasad Sakshi , Abdul Rasool Aniqa , Walia Namrata , Bachu Anil
Published: November 2022

Olfactory Reference syndrome (ORS) is characterized by patients falsely believing that they exude a foul body odor, which is embarrassing and disturbing to the patient. The increased anxiety due to this belief leads to compulsive behaviors, social anxiety, and functional impairment. ORS poses enormous challenges in its diagnosis and treatment. The disorder can be often treatment-resistant or recurrent. A case formulation followed by a classificatory diagnosis is an effective approach to distinguish it from other diagnoses with an overlapping spectrum of symptoms. Here, we present a case of a 42-year-old Australian woman with recurrence of ORS post major stressful triggers. She reported a trial of a series of expensive cosmetic and hydraulic treatments, however, her symptoms persisted, causing significant deterioration in her mood and social functioning, interpersonal relationships, and self-care. Patient was brought to the psychiatric inpatient unit with the complaint of feeling unsafe in her own house. She was started on Lurasidone, along with 12 weeks of intense cognitive behavioral sessions. The use of psychotherapy is underreported even though it significantly reduces ongoing distress. The patient remains asymptomatic along with improved social functioning on subsequent follow-ups.
European colonization and the transmission of the Ewondo language in Cameroon and Abroad: Historical and transnational perspectives
Authors: Belibi Alexis-Bienvenu , Pape Elise
Published: November 2022

European colonization has deeply marked the linguistic practices in different African territories until today. Cameroon, which was colonized by Germany from 1884 to 1916 and by France and Great Britain from 1916 to 1960, is formally a bilingual country with French and English being its two official languages. However, the linguistic reality of the country goes way beyond these two languages. Today, more than 250 African languages are spoken in Cameroon. This article focuses on the experiences of Alexis-Bienvenu Belibi, who was born in Yaoundé in 1950 and who is today Professor Emeritus of African languages at the École normale supérieure of Yaoundé. The article evokes Belibi’s family history, his schooling, university studies and his career as a high school teacher and as a university professor. It thereby examines the different school policies implemented in Cameroon toward African languages over time as well as the impact of university actors on ongoing political changes in the educational field. It also addresses demands from the Cameroonian diaspora in Europe and the world concerning the learning of Ewondo. The article is written in the form of a conversation between Alexis-Bienvenu Belibi and Elise Pape, a Franco-German sociologist specialized in the fields of migration studies and of postcolonial memories.
The ethical costs of using higher education for economic mobility
Authors: Webster Dustin
Published: November 2022

A great deal of recent scholarship on economically disadvantaged students and higher education works under the foundational assumption that going to college can and/or should serve the goal of economic mobility. This article considers a cost of using higher education for this purpose – specifically, the impact on the decision-making of poor students. I argue that the narrative of higher education for economic mobility places poor students in a problematically restrictive normative framework as compared with their wealthier peers in which decisions involving the pursuit of future economic goods change from matters of preference into ethical dilemmas. In turn, poor students are forced into a narrow cost–benefit, consequentialist mode of decision-making. This is especially problematic because higher education for many students is a transformative experience – a type of experience which is particularly unsuited to consequentialist reasoning. The solution involves reframing the way in which we think about decision-making in higher education, which is at least partially contingent on increasing social supports to shift the burdens of poverty off individual students.