bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum metabolomics of treatment response in myasthenia gravis
Authors: Sikorski Patricia , Li Yaoxiang , Cheema Mehar , Wolfe Gil I. , Kusner Linda L. , Aban Inmaculada , Kaminski Henry J.
Published: October 2023

Objective

High-dose prednisone use, lasting several months or longer, is the primary initial therapy for myasthenia gravis (MG). Upwards of a third of patients do not respond to treatment. Currently no biomarkers can predict clinical responsiveness to corticosteroid treatment. We conducted a discovery-based study to identify treatment responsive biomarkers in MG using sera obtained at study entry to the thymectomy clinical trial (MGTX), an NIH-sponsored randomized, controlled study of thymectomy plus prednisone versus prednisone alone.

Methods

We applied ultra-performance liquid chromatography coupled with electro-spray quadrupole time of flight mass spectrometry to obtain comparative serum metabolomic and lipidomic profiles at study entry to correlate with treatment response at 6 months. Treatment response was assessed using validated outcome measures of minimal manifestation status (MMS), MG-Activities of Daily Living (MG-ADL), Quantitative MG (QMG) score, or a strictly defined composite measure of response.

Results

Increased serum levels of phospholipids were associated with treatment response as assessed by QMG, MMS, and the Responders classification, but all measures showed limited overlap in metabolomic profiles, in particular the MG-ADL. A panel including histidine, free fatty acid (13:0), γ-cholestenol and guanosine was highly predictive of the strictly defined treatment response measure. The AUC in Responders’ prediction for these markers was 0.90 irrespective of gender, age, thymectomy or baseline prednisone use. Pathway analysis suggests that xenobiotic metabolism could play a major role in treatment resistance. There was no association with outcome and gender, age, thymectomy or baseline prednisone use.

Interpretation

We have defined a metabolomic and lipidomic profile that can now undergo validation as a treatment predictive marker for MG patients undergoing corticosteroid therapy. Metabolomic profiles of outcome measures had limited overlap consistent with their assessing distinct aspects of treatment response and supporting unique biological underpinning for each outcome measure. Interindividual variation in prednisone metabolism may be a determinate of how well patients respond to treatment.
Deep coverage and quantification of the bone proteome provides enhanced opportunities for new discoveries in skeletal biology and disease
Authors: Rose Jacob P. , Schurman Charles A. , King Christina D. , Bons Joanna , Patel Sandip K. , Burton Jordan B. , O’Broin Amy , Alliston Tamara , Schilling Birgit
Published: October 2023

Dysregulation of cell signaling in chondrocytes and in bone cells, such as osteocytes, osteoblasts, osteoclasts, and an elevated burden of senescent cells in cartilage and bone, are implicated in osteoarthritis (OA). Mass spectrometric analyses provides a crucial molecular tool-kit to understand complex signaling relationships in age-related diseases, such as OA. Here we introduce a novel mass spectrometric workflow to promote proteomic studies of bone. This workflow uses highly specialized steps, including extensive overnight demineralization, pulverization, and incubation for 72 h in 6 M guanidine hydrochloride and EDTA, followed by proteolytic digestion. Analysis on a high-resolution Orbitrap Eclipse and Orbitrap Exploris 480 mass spectrometer using Data-Independent Acquisition (DIA) provides deep coverage of the bone proteome, and preserves post-translational modifications, such as hydroxyproline. A spectral library-free quantification strategy, directDIA, identified and quantified over 2,000 protein groups (with ≥ 2 unique peptides) from calcium-rich bone matrices. Key components identified were proteins of the extracellular matrix (ECM), bone-specific proteins (e.g., secreted protein acidic and cysteine rich, SPARC, and bone sialoprotein 2, IBSP), and signaling proteins (e.g., transforming growth factor beta-2, TGFB2), and lysyl oxidase homolog 2 (LOXL2), an important protein in collagen crosslinking. Post-translational modifications (PTMs) were identified without the need for specific enrichment. This includes collagen hydroxyproline modifications, chemical modifications for collagen self-assembly and network formation. Multiple senescence factors were identified, such as complement component 3 (C3) protein of the complement system and many matrix metalloproteinases, that might be monitored during age-related bone disease progression. Our innovative workflow yields in-depth protein coverage and quantification strategies to discover underlying biological mechanisms of bone aging and to provide tools to monitor therapeutic interventions. These novel tools to monitor the bone proteome open novel horizons to investigate bone-specific diseases, many of which are age-related.
Fostering Independent Learning in Early Childhood: A Case Study on Montessori Pedagogy at PAUD Montessori Futura Indonesia
Authors: Qadafi Muammar , Maulidya Ulfah  , Miftachul Huda  , Agustiningsih Neneng
Published: October 2023

The primary objective of this research is to assess the effectiveness of Montessori pedagogy in nurturing independent learning in early childhood education, specifically at PAUD Montessori Futura Indonesia. Utilizing a descriptive case study approach, the study examines daily routines, learning activities, and the role of educators in fostering independence. The findings indicate that children consistently engage in independent behaviors, such as choosing activities autonomously and requiring minimal teacher intervention. Educators are instrumental in crafting activities that bolster independent learning, and the learning facilities are strategically organized to facilitate this objective. The practice of age grouping within the institution further enriches the learning environment by instilling a sense of responsibility among older children. These outcomes have considerable implications for both research and practice in early childhood education, suggesting that Montessori pedagogy can effectively promote independent learning. However, the study is confined to a single educational setting and does not explore the Montessori approach's long-term effects or adaptability in diverse socio-cultural contexts. Future research is recommended to investigate these areas for a more holistic understanding of the efficacy of Montessori pedagogy in promoting independent learning.
Llegando a la universidad. Aspiraciones y experiencias de universitarios de primer año de licenciatura en México
Authors: Mata Zúñiga Luis Antonio
Published: October 2023

Este artículo analiza las aspiraciones de estudiantes de primer año de seis universidades en México que mantienen importantes diferencias tanto por régimen, público-privado; por nivel de desarrollo institucional, consolidado o en desarrollo; por la composición social de sus estudiantes; así como por la ubicación geográfica de las universidades. Para recuperar estas diferencias y observar su relación con las aspiraciones de universitarios se movilizan los conceptos: Espacios Universitarios Asimétricos (EUA) (Villa Lever et al., 2017); aspiraciones (Appadurai, 2004) y condición juvenil (Reguillo, 2010). Se elaboran conclusiones sobre las diferencias entre la capacidad de construir horizontes de futuro de los universitarios y su relación con asimetrías encontradas en los EUA mediante el análisis estadístico de 1605 encuestas y de 31 entrevistas semiestructuradas.
Ideological orientations and left-right self-identifications of young Polish men and women: an image of the political gender-generation gap
Authors: Marzęcki Radosław
Published: October 2023

The subject of the author’s interest is the diversity of ideological orientations due to gender and age. The theoretical findings so far indicate that in developed democracies already at the end of the 1990s there was a reversal of the ideological positions of women and men. Recent social research shows that also in Poland women identify with the left to a greater extent than men, and in the younger generation these differences are even greater. The aim of the article is to show in detail the ideological differences between young men and women in Poland. The author poses two types of research questions: (1) descriptive and explanatory, which concern the characteristics of similarities and differences in the ideological orientations of young women and men; (2) methodological, which concern how to measure this phenomenon. The author assumes that the measurement of left-right self-identification used in many studies brings an overly simplified picture of the respondents’ real views, beliefs and values, which can be described as ideological orientations. Therefore, he proposes the use of multidimensional tools (issue-based scale) that allow to better describe complex political attitudes. In search of answers, the author analyzes data from his own survey conducted among a large group of Polish students.
The Role of the Committee in the Control Function of the Sejm of the Republic of Poland
Authors: Kropiwnicki Robert
Published: October 2023

The article discusses the role of the committee in the control function of the Sejm of the Republic of Poland. Committees are one of the key bodies of the Sejm. They perform a significant range of work, both legislative and control. The article discusses the competences of parliamentary committees, highlights the importance of the presence of the most important people in the state at their meetings and indicates the possibilities of increasing the effectiveness of the committee’s control activities.
Ogniwo Artura Marii Swinarskiego w serii translatorskiej utworów Johanna Wolfganga Goethego
Authors: Grodecka Aneta
Published: October 2023

Based on the findings of translation experts on the translation series, the author focuses on Polish-German tropes in the works of A.M. Swinarski, carrying out a detailed analysis of selected translations of Goethe’s poems. A comparison of translations by Swinarski, Jarosław Iwaszkiewicz, Stefan Zarębski, Feliks Konopka and Andrzej Lam reveals changes in the sphere of meanings designed in the original and reflects on the principles of literality and interpretation in translation practice.
Effect of regional baric systems on the occurrence of bi- oclimatic conditions in Poland
Authors: Tomczyk Arkadiusz M. , Bednorz Ewa , Szyga-Pluta Katarzyna , Owczarek Małgorzata
Published: October 2023

The present study concerns the determination of the characteristics of bioclimatic conditions, as well as the synoptic situations related to the occurrence of thermal stress conditions, in Poland. The study was based on daily data obtained from the Institute of Meteorology and Water Management – National Research Institute from the period 1966–2020 for 37 synoptic stations in Poland. Based on the obtained data, values of the Universal Thermal Climate Index (UTCI) were calculated. The occurrence of heat stress increases from the north to the south, corresponding with the variability of influx of solar radiation, and is modified by factors at a smaller spatial scale. The results of this paper evidently point to the cooling effect of the waters of the Baltic Sea. In circulation conditions favouring strong and very strong heat stress, e.g. in two of the designated circulation types (T1 and T2), the occurrence of an expansive high-pressure ridge in the Atlantic-European area is typical, stretching from the region of the Azores High towards the north- east, with a secondary high developed within its boundaries. In the third of the designated circulation types (T3), the high-pressure area extends from the Azores eastwards, reaching the Black Sea. Each of the three circulation patterns associated with the unfavourable biometeorological conditions of very strong and extreme cold stress in Poland is characterised by strong pressure centres formed in the Euroatlantic region, triggering the airflow from the northern (T4) or eastern (T5, T6) sector.
Influence of pharmacogenetics on the diversity of response to statins associated with adverse drug reactions
Authors: Sainz de Medrano Sainz Jaime I. , Brunet Serra Mercè
Published: October 2023

Background

Statins are one of the most prescribed medications in developed countries as the treatment of choice for reducing cholesterol and preventing cardiovascular diseases. However, a large proportion of patients experience adverse drug reactions, especially myotoxicity. Among the factors that influence the diversity of response, pharmacogenetics emerges as a relevant factor of influence in inter-individual differences in response to statins and can be useful in the prevention of adverse drug effects.

Content

A systematic review was performed of current knowledge of the influence of pharmacogenetics on the occurrence and prevention of statin-associated adverse reactions and clinical benefits of preemptive pharmacogenetics testing.

Genetic variants SLCO1B1 (rs4149056) for all statins; ABCG2 (rs2231142) for rosuvastatin; or CYP2C9 (rs1799853 and rs1057910) for fluvastatin are associated with an increase in muscle-related adverse effects and poor treatment adherence. Besides, various inhibitors of these transporters and biotransformation enzymes increase the systemic exposure of statins, thereby favoring the occurrence of adverse drug reactions.

Outlook

The clinical preemptive testing of this pharmacogenetic panel would largely prevent the incidence of adverse drug reactions. Standardized methods should be used for the identification of adverse effects and the performance and interpretation of genotyping test results. Standardization would allow to obtain more conclusive results about the association between SLCO1B1, ABCG and CYP2C9 variants and the occurrence of adverse drug reactions. As a result, more personalized recommendations could be established for each statin.
Subverting motion in science fiction? Beam in the Star Trek TV series
Authors: Törmä Kajsa
Published: October 2023

Characters in science fiction TV have to move through the universe at the speed which the plot necessitates. In Star Trek, characters can beam from one location to another in an instant. In the visual modality, there is no continuous path of motion between the source and the goal, which would technically disqualify beam from most linguistic definitions of motion. This study aims to map out the usage patterns of beam and investigate whether or not it is linguistically construed as motion within the show. The study is based on a section of the TV Corpus (Davies, Mark. 2019. The TV Corpus. https://www.english-corpora.org/tv/ (accessed 28 May 2022)) consisting of all available episodes of all Star Trek TV series between 1966 and 2005 and uses a combination of quantitative and qualitative methods. The study found that beam is indeed used as a motion verb within the series. Its usage is also quite varied, denoting motion of many different figures in many different directions. The fact that we conceive of beaming as motion even though there is no continuous path might be partly explained by the etymology of beam, and partly by the embodied nature of language. Our current register makes it is hard to imagine transportation without movement.
Crystal structure of 1,4-dibromo-2,5-bis(2-methoxyethoxy)benzene-1,4-diol, C12H16Br2O4
Authors: Wang Zhi-Yong , Lu Wan-Li , Zhou Xu , Yang Xian-Jiong , Zhang Qi-Long , Xu Hong
Published: October 2023

C12H16Br2O4, monoclinic, P21/n (no. 14), a = 12.594(5) Å, b = 4.4613(16) Å, c = 12.878(4) Å, β = 91.209(12)∘, V = 723.4(4) Å3, Z = 2, R
gt(F) = 0.0450, wR
ref(F
2) = 0.1103, T = 293 (2) K.
Countermovement Jump Force-Time Curve Analyses: Reliability and Comparability Across Force Plate Systems
Authors: Merrigan Justin J. , Strang Adam , Eckerle Jason , Mackowski Nick , Hierholzer Kaela , Ray Nicole T. , Smith Roger , Hagen Joshua A. , Briggs Robert A.
Published: October 2023

Merrigan, JJ, Strang, A, Eckerle, J, Mackowski, N, Hierholzer, K, Ray, NT, Smith, R, Hagen, JA, and Briggs, RA. Countermovement jump force-time curve analyses: reliability and comparability across force plate systems. J Strength Cond Res 38(1): 30–37, 2024—Considering the growing prevalence of commercial force plates providing automated force-time analyses, understanding levels of agreement across force plate systems is warranted. Countermovement jump (CMJ) metrics across Vald ForceDecks (FD), Hawkin Dynamics (HD), and Sparta Science (SS) force plate systems were compared. Twenty-two subjects completed CMJ testing (∼128 comparisons) on each force plate system separately with rest between jumps. Baseline testing occurred 3 times and demonstrated poor test-retest reliability for modified reactive strength index (mRSI) and rate of force development (RFD). ForceDecks and HD comparisons yielded acceptable agreement for concentric/propulsive relative force and net impulse, jump height, eccentric/braking RFD, and mRSI, but systematic and proportionate bias existed for RFD. Sparta Science jump height and reactive strength index (RSI) demonstrated systematic overestimations compared with HD and FD, but jump height had acceptable agreement according to concordance correlation coefficients (CCC = 0.92–0.95). Agreement between SS load (eccentric RFD) and HD braking RFD was acceptable (CCC = 0.91), whereas agreement between SS load and FD deceleration RFD was considered acceptable (CCC = 0.81–0.87) but demonstrated systematic and proportionate bias. ForceDecks (CCC = 0.89) and HD (CCC = 0.85) average relative concentric/propulsive force yielded acceptable agreement with SS explode (average relative concentric force), but SS explode demonstrated systematically lower values than FD and HD. Sparta Science drive (concentric impulse) yielded acceptable agreement with HD relative propulsive impulse (CCC = 0.85), but not FD concentric impulse. Human performance practitioners need to be aware of inconsistencies among testing procedures and analyses across force plate systems, such as differences in metric definitions and units of measurement, before making comparisons across systems.
Effect of Extreme Volume-Load Differences for a Single Unilateral Exercise During In-Season Resistance Training on Measures of Bilateral Strength, Power, and Speed in Collegiate American Football Players
Authors: Crawley Katie , Adams Kent J. , DeBeliso Mark , Lawrence Marcus M.
Published: October 2023

Crawley, K, Adams, KJ, DeBeliso, M, and Lawrence, MM. Effect of Extreme Volume-Load Differences for a Single Unilateral Exercise During In-Season Resistance Training on Measures of Bilateral Strength, Power, and Speed in Collegiate American Football Players. J Strength Cond Res XX(X): 000–000, 2023—This study examined the impact extreme volume-load differences for a single weekly exercise, when all other exercises' volume loads were similar, would have on American football performance variables after in-season resistance training (RT). Twenty male National Collegiate Athletic Association (NCAA) American footballers (18–23 years, 98.4 ± 19.3 kg) were randomly assigned to an extreme high-volume low-intensity (EHVLI; n = 11) group or a low-volume high-intensity (LVHI; n = 9) group. Subjects performed the same evidence-based RT exercises and volume loads for 8 weeks thrice weekly, with the only differences being once weekly unilateral reverse dumbbell lunge (EHVLI) or unilateral Hatfield safety bar back squat (LVHI) exercises performed with different volume loads. Performance variables were assessed 1 week before (PRE) and after (POST) 8 weeks of RT. A 2-way analysis of variance with repeated measures and the Sidak post hoc test were used (p < 0.05). Extreme high-volume low-intensity had no significant (p > 0.05) PRE-to-POST RT changes in muscular strength in 1 repetition maximum (251.8 ± 48.7 to 274.6 ± 61.3 kg) or power in vertical jump (79.2 ± 8.8 to 78.2 ± 10.8 cm). Conversely, LVHI had significant (p < 0.05) PRE-to-POST RT improvements in strength (249.2 ± 54.4 to 284.1 ± 55.0 kg) and power (72.8 ± 11.4 to 76.3 ± 10.0 cm). Furthermore, LVHI vs. EHVLI displayed significantly greater percentage difference increases from PRE values in muscular power (6.7% ± 7.2 vs. −1.3% ± 6.0, respectively), with no significant differences between groups (LVHI vs. EHVLI) in muscular strength (8.8% ± 3.1 vs. 6.7% ± 8.0, respectively) and 10-yard acceleration (2.2% ± 5.6 vs. 3.2% ± 5.6, respectively). For in-season RT of strength and power in collegiate American football players, all exercises performed should use evidence-based volume loads to optimize adaptations because a single exercise performed with extreme volume load may limit muscular strength and power development.
‘A glimmer of hope’: perceptions, barriers, and drivers for medicinal cannabis use amongst Australian and New Zealand people with endometriosis – a qualitative study
Authors: Sinclair Justin , Abbott Jason , Mikocka-Walus Antonina , Ng Cecilia , Sarris Jerome , Evans Subhadra , Armour Mike
Published: October 2023

Previous quantitative research has shown that cannabis use, mostly illicit, is used for symptom management amongst those with endometriosis living in Australia or New Zealand, but the drivers and barriers for use of legal, medicinal cannabis in this population are currently unclear. This study sought to investigate, via online focus groups, the perceptions, barriers, drivers, and experiences associated with cannabis use, whether legal or illicit, amongst 37 Australians and New Zealanders, aged 18–55, with a medical diagnosis of endometriosis. Previous cannabis usage was not required to participate. Discussion topics included strategies employed to manage symptoms, exploration of current medications, previous use of cannabis for pain management, and interest in using medicinal cannabis as a management strategy. Participants with moderate-to-severe symptoms of medically diagnosed endometriosis reported inadequacies with their current medical and self-management strategies and were inclined to try medicinal cannabis, both as part of their medical management and as part of a clinical trial. Barriers to medicinal cannabis adoption identified in this cohort included high costs of legal cannabis products, lack of clarity and fairness in current roadside drug testing laws and workplace drug testing policies, concern over the impact of stigma affecting familial, social and workplace life domains, and subsequent judgement and the lack of education/engagement from their medical providers regarding cannabis use. Given the interest in medicinal cannabis and the reported lack of effective symptom management, clinical trials are urgently required to determine the potential role that medicinal cannabis may play in reducing the symptoms of endometriosis.

Lay summary

Previous research has demonstrated that cannabis, either medically or illicitly obtained, is being used to manage the pain and associated symptoms of endometriosis in people across Australia and New Zealand. However, there are no clinical trials yet to determine how safe and effective medicinal cannabis might be for endometriosis symptoms. Before we design our clinical trial we wanted to get input from people in the community who have endometriosis to understand what kind of barriers there might be to both being in a clinical trial and using medicinal cannabis for their symptoms. Overall, the vast majority of participants were open to trying medicinal cannabis as a management option, driven mainly by inadequacies in their current medical and self-management strategies. Several barriers to adoption were identified, including the high costs of legal cannabis products, current drug driving laws or workplace drug testing policies, and the negative stigma around cannabis usage.
Peran Knowledge Management di Perpustakaan Dalam Meningkatkan Good Governance Pada Organisasi
Authors: Lolytasari Lolytasari , Rianti Fahma
Published: October 2023

Dalam menciptakan tata kelola, atau good governance, pemerintah perlu melakukan reformasi birokrasi di semua lini dan aspek pada institusi. Agar reformasi birokrasi dapat berjalan dengan baik, salah satu yang perlu dilakukan adalah merubah pola pikir (mind set) dan budaya kerja (culture set) dari aparatur pemerintah. Untuk itu perlu dilakukan berbagai program KM di insitusi tersebut. Program-program tersebut dapat diinisiasi oleh perpustakaan di lingkungan institusi pemerintah. Hal ini menjadi salah satu peran besar perpustakaan sebagai salah satu pendukung utama tercapainya visi dan cita-cita institusi yang menaunginya.Peran perpustakaan dalam proses KM adalah pada tahap pengadaan, penyimpanan dan penyebaran pengetahuan. Beberapa contoh program KM yang dapat dilaksanakan perpustakaan untuk merubah mind set dan culture set aparatur pemerintah adalah Survei, FGD, Sosialisasi, pelatihan, knowledge sharing, sistem reward serta evaluasi. Program ini diharapkan dapat membantu proses reformasi birokrasi di instansi pemerintah, yang kemudian akan meningkatkan performa layanan publik di Indonesia.
Informasi Skill dan Penyandang Disabilitas Netra BRSPDSN Tan Miyat
Authors: Novia Putri Dwi , Alfida Alfida
Published: October 2023

Hasil penelitian menunjukan faktor yang mendorong kebutuhan informasi penyandang disabilitas netra BRSPDSN Tan Miyat dilandasi 3 hal yaitu faktor pribadi, peran sosial, dan lingkungan. Kebutuhan informasi utama yang dimiliki penyandang disabilitas netra ialah informasi mengenai cara mengoperasikan komputer bicara dan cara mengetik dengan sepuluh jari. Sedangkan, informasi mengenai penggunaan Microsof Office (word, excel, power point), cara membuat Blog, membuat konten di youtube, mengedit gambar, dan juga editing musik, merupakan kebutuhan informasi didasari oleh minat dan juga profesi yang berhubungan. Tahapan perilaku pencarian informasi yang dilalui ialah tahapan perhatian pasif hingga pencarian aktif. Penyandang disabilitas netra tidak melakukan tahapan pencarian berlanjut dikarenakan setelah memperoleh informasi yang dibutuhkannya, mereka cenderung akan langsung menggunakan informasi tersebut untuk dipraktekan mengingat informasi yang dicarinya ialah mengenai keterampilan komputer. Penulis menyarankan agar BRSPDSN Tan Miyat dapat lebih mengedukasi penyandang disabilitas netra dalam menggunakan sumber informasi otoritatif berupa teks yang dapat didukung oleh software screen reader ataupun sumber-sumber informasi lain, keluarga serta lingkungan penyandang disabilitas netra penyandang disabilitas BRSPDSN Tan Miyat dapat terus memotivasi dan mendukung agar mereka dapat terus terampil dan berkarya, serta diadakannya penelitian lanjutan terkait pengembangan tekonolgi dalam mendukung pencarian informasi penyandang disabilitas netra.
Tinjauan Pengelolaan Arsip Ideal Kabupaten Melalui Pengawasan Kearsipan di Kabupaten Dairi Sumatera Utara
Authors: Safitri Dyah , Putri Sion Sihombing Liyanti Damena
Published: October 2023

Pengawasan kearsipan di Indonesia sudah memiliki aturan hukum yang jelas. Semua aspek pengelolaan kearsipan yang baik sudah diberikan dalam aturan hukum itu. Tetapi, pelaksanaan di semua level memiliki tantangan tersendiri seperti untuk tingkat kabupaten/kota. Penelitian ini menggunakan metode penelitian kualitatif deskriptif untuk mengamati praktik pengawasan kearsipan di kabupaten Dairi Sumatera Utara. Hasilnya adalah pelaksanaannya sudah berjalan sesuai tetapi karena keterbatasan anggaran sejumlah poin tidak dapat terlaksana. Sebaiknya ada aturan tambahan tentang bagaimana solusi bagi pemerintah kabupaten/kota dapat tetap melaksanakan pengawasan dengan anggaran yang ada.
Memahami Konsep Pustakawan Subjek
Authors: Nuryaman Nuryaman
Published: October 2023

Menimbang belum maraknya istilah dan aktivitas kepustakawanan berbasis pustakawan subjek, sedangkan peran dan fungsinya sangat diperlukan untuk pendayagunaan sumber informasi dalam memenuhi kebutuhan pemustaka yang semakin kompleks, maka disusunlah penelitian untuk mendeskripsikan konsep pustakawan subjek. Peneliti memanfaatkan studi literatur karena keseluruhan temuan dan pembahasan bersumber dari referensi-referensi yang relevan dengan topik kajian. Dari hasil studi, ditemukan bahwa pustakawan subjek belum banyak dibahas dalam bentuk komunikasi ilmiah yang terbukti dengan terbatasnya hasil penelusuran menggunakan kata kunci “pustakawan subjek” pada publikasi daring nasional, bahkan hasil penelusuran via Google kurang dari 300 pembahasan. Secara terminologi pun, terdapat sejumlah istilah populer namun terkesan belum konsisten untuk mendeskripsikan peran dan fungsi pustakawan subjek meliputi pustakawan subjek, pustakawan spesialis, pustakawan subjek spesialis dan pustakawan liaison. Dalam pembahasan, dipaparkan perihal pemakanaan istilah dan definisi pustakawan subjek, menggali peran dan fungsinya, serta menelaah tantangan dan peluang menjadi pustakawan subjek. Adanya penjabaran konsep tersebut diyakini memberi pencerahan terhadap profesionalisme pustakawan subjek dalam konteks nasional maupun global. Peran dan fungsi pustakawan subjek perlu dibenahi dalam rangka pemanfaatan sumber informasi perpustakaan serta peningkatan citra pustakawan sebagai manajer informasi. Sebagai simpulan, pustakawan subjek berkedudukan sebagai pustakawan yang mafhum secara teori dan praktis terhadap subjek yang ditekuninya, sehingga memudahkan proses penelusuran informasi berbasis perpustakaan. Rekomendasinya, pustakawan subjek idealnya mulai didesain dan diimplementasikan secara berkelanjutan dalam pemanfaatkan koleksi. layanan dan program perpustakaan.
Transformasi Perpustakaan Riset: Studi Kasus Perpustakan Riset Sekolah Pascacasarjana UIN Syarif Hidayatullah Jakarta
Authors: Rifai Agus
Published: October 2023

Perpustakaan perguruan tinggi diharapkan mampu berperan dalam mendukung kegiatan akademik, terutama untuk kepentingan pembelajaran dan riset. Penelitian ini bertujuan mengetahui persepsi mahasiswa terhadap keberadaan perpustakaan sebagai pondasi kegiatan riset di perguruan tinggi. Penelitian ini dilakukan dengan melakukan survei terhadap 50 mahasiswa program pascasarjana di lingkungan Sekolah Pascasarjana UIN Syarif Hidayatullah Jakarta. Data dikumpulkan dengan menggunakan kuesioner atau angket untuk mendapatkan respon mahasiwa pascasarjana yang berupa penilaian dan harapan-harapan terhadap perpustakaan dalam rangka mendukung kegiatan riset. Data dianalisis dengan menggunakan metode analisi statistik deskriptif dengan bantuan aplikasi SPSS Versi 23. Berdasarkan data yang dikumpulkan, responden menaruh harapan yang tinggi terhadap perpustakaan untuk lebih berperan sebagai institusi riset. Keberadaan perpustakaan sebagai mitra riset diharapkan dapat memenuhi perubahan kebutuhan peneliti,
Perkembangan Kajian Pendidikan Islam Pada Publikasi Internasional Terindeks Scopus Tahun 2017-2021
Authors: Andayani Ulpah
Published: October 2023

Kajian pendidikan Islam merupakan salah satu kajian penting dalam literatur ilmu Pendidikan, khususnya di Indonesia. Berbagai jurnal dan publikasi tentang Pendidikan Islam telah dihasilkan oleh banyak peneliti. Paper ini bertujuan mengkaji dan mendeskripsikan perkembangan publikasi Pendidikan Islam yang terindeks Scopus. Sumber data kajian ini adalah database Scopus. Kajian dilakukan memasukan kata kunci “pendidikan Islam” (Islamic Education) pada judul, abstrak, dan keyword pada publikasi. Data hasil penelusuran Scopus selanjutnya dianalisis dengan melakukan kategori subyek dari tahun ke tahun. Berdasarkan hasil analisis, topik-topik kajian Pendidikan Islam menunjukan keragaman dari tahun ke tahun. Keragaman ini menunjukkan karakteristik kajian Pendidikan Islam yang terbuka dari banyak pendekatan, dan merespon perubahan yang terjadi di masyarakat.
Menelusuri Jejak Literasi Masyarakat Melayu Palembang
Authors: Syafran Nurmalina
Published: October 2023

Membicarakan sejarah literasi, tentunya tidak bisa dilepaskan dengan proses terbentuknya tradisi intelektual budaya Melayu. Tradisi intelektual ini erat kaitannya dengan literasi yang mana literasi dimaknai secara sederhana adalah kemampuan menulis dan membaca. Dilihat dari sejarahnya literasi baca tulis masyarakat Palembang sudah dimulai semenjak adanya tradisi intelelektual di dunia Melayu. Tradisi ini secara historis dan intelektual telah memberikan sumbangan besar dalam membangun konstruksi keilmuan Islam di Dunia Melayu. Terbentuknya tradisi Intelektual di Dunia Melayu diawali dari kebutuhan untuk mentransmisikan ilmu keislaman dari asalnya di Timur Tengah. Transmisi ilmu dilakukan melalui penyalinan ataupun penerjemahan naskah-naskah ke dalam bahasa lokal. Kemudian berkembang kepada tradisi penulisan berbagai disiplin ilmu oleh para ulama local Melayu. Sejarah juga membuktikan bahwa kegemaran membaca masyarakat Melayu Palembang sudah membudaya sejak lama, hal ini ditunjukkan dengan adanya rumah sewa buku.
Layanan Referensi Virtual di UPT Perpustakaan Uin Sunan Kalijaga Yogyakarta di Era Pandemi Covid-19
Authors: Wahyani Wahyani
Published: October 2023

Pandemi Covid-19 memberikan dampak yang begitu besar tidak hanya masyarakat Indonesia tetapi bahkan dunia pada umumnya. Dampak tersebut dirasakan oleh berbagai sektor, salah satunya perpustakaan. Dengan demikian diperlukan perubahan secara cepat, dimana perpustakaan harus mampu memanfaatkan kemajuan teknologi informasi dan komunikasi untuk mendukung layanannya.Tulisan ini mengkaji berbagai layanan yang telah dilakukan oleh Perpustakaan UIN Sunan Kalijaga Yogyakarta semenjak pandemic covid-19 mewabah di Indonesia, terutama layanan referensi virtual atau online. Penelitian ini merupakan penelitian kualitatif dengan menggunakan pendekatan deskriptif analitik. Penelitian ini mengungkap bahwa semenjak awal masa pandemic covid-19 yaitu pada Bulan Maret 2020 bahkan sebelum covid, Perpustakaan sudah mengimplementasikan layanan referensi virtual melalui media chatting atau Whatsapp dan email.
Menumbuhkan Literasi Anak Melalui Taman Bacaan Masyarakat Himpunan Mahasiswa Prodi Ilmu Perpustakaan dan Informasi Islam IAIN Curup
Authors: Marleni Marleni , Murdani Hati
Published: October 2023

Perguruan tinggi memegang  peranan dalam  menumbuhkan literasi pada masyarakat sesuai dengan tri dharma yang ada. Dalam hal ini salah satunya adalah kemampuan baca tulis masyarakat. Tumbuhnya kebiasaan membaca terkhususnya pada anak dapat mendorong peningkatan kualitas hidup masyarakat. Tulisan ini mengkaji bagaimana membangun dan menumbuhkan literasi anak berdasarkan pengalaman program Taman Bacaan Masyarakat oleh Himpunan Mahasiswa Prodi Ilmu Perpustakaan IAIN Curup. Penelitian ini bertujuan untuk mengetahui peran Himpunan Mahasiswa Prodi Ilmu Perpustakaan dalam  menumbuhkan literasi anak . Metode penelitian yang digunakan yaitu metode penelitian kualitatif deskriptif. Hasil penelitian ini diperoleh bahwa Taman Bacaan Masyarakat ini dibangun oleh Himpunan Mahasiswa Prodi Ilmu Perpustakaan IAIN Curup berlokasi di Kabupaten Rejang lebong, Bengkulu dimulai sejak tahun 2021, untuk memeberikan kesadaran kepada anak-anak mengenai literasi dengan cara memberikan edukasi diberbagai bidang ilmu yang diberikan langsung oleh pelaksana Taman Bacaan Masyarakat dengan ini peranan Taman Bacaan benar-benar dapat memperkuat pengetahuan anak-anak bahkan masyarakat di  kabupaten Rejang Lebong.
Peranan Perpustakaan Terhadap Pentingnya Pembinaan dan Peningkatan Minat Baca
Authors: Makdis Nasrul , Jendri Jendri
Published: October 2023

Tulisan ini bertujuan untuk menjelaskan secara konferehensif terhadap peranan kepustakaan terhadap pembinaan minat baca yang sesuai dengan prinsip-prinsip yang telah ditentukan. Yang nantinya bisa diterapkan secara operasional dan bahkan menumbuhkan minat baca secara signifikansi. Penelitian ini menggunakan penelitian kualitatif yang bersifat studi kepustakaan (library research) yang menggunakan buku-buku atau literatur yang berhubungan dengan penelitian ini untuk dijadikan sebagai objek utama penalitian, yang kemudia dianalisis secara deskriptif induktif untuk memberikan sebuah gambaran dengan jelas, objektifitas, dan sitematismengenai peranan kepustakaan terhadap pembinaan minat baca. Dari hasil pembahasan  penelitian ini menunjukan bahwa, kurangnya maraknya  ditemukan di kalangan masyarakat dalam minat baca bahkan masyarakat tidak mau membaca dan mencari informasi mengenai sesuatu, padahal dengan perkembangan teknologi mudahnya untuk mengakses bahan bacaan deberbagai tempat misalnya diperpustakaan supaya menjadikan masyarakat yang cerdas dalam perihal membaca. Namun hal in memiliki faktor secara internal maupun eksternal, atau disebut juga dengan istilah tranpormatif.
Perilaku Penelusuran Informasi Mahasiswa UIN Jakarta Dalam Menyelesaikan Tugas Akhir Selama Pandemi Covid-19
Authors: Nuryaman Nuryaman , Hasbana Amrullah
Published: October 2023

Penelitian ini bertujuan menginvestigasi perilaku penelusuran informasi mahasiswa dalam menyelesaikan tugas akhir selama Pandemi Covid-19. Peneliti menggunakan pendekatan kuantitatif deskriptif dalam mencapai tujuan penelitian. Sampel diambil dari populasi yang memenuhi kriteria sedang atau telah menyusun tugas akhir dan diperoleh 100 responden. Analisis data menggunakan statistik deskriptif untuk menggambarkan kondisi perilaku penelusuran mahasiswa secara keseluruhan dan pada setiap prosesnya sesuai Big 6 Model. Hasil dan pembahasan menunjukkan bahwa perilaku penelusuran informasi mahasiswa dalam menyelesaikan tugas akhir dianggap sudah baik dengan total skor 4.788, berkategori baik. Hasil ini didukung pula oleh masing-masing tahapan penelusuran yang dominan berkategori baik (rentang skor 680-840), yaitu task definition (852) information seeking strategies (815), location and access (788), use of information (799), synthesis (780) dan evaluation (754). Kondisi ini menunjukkan bahwa mahasiswa akhir memiliki persepsi baik terhadap keterampilan menelusur informasi selama Pandemi Covid-19 dengan skor tertinggi pada tahap task definition dan skor terendah evaluation. Sebagai rekomendasi, mahasiswa dan pemangku kepentingan dapat meningkatkan keterampilan mengevaluasi hasil penelusuran dan penelitian dapat ditindaklanjuti dengan perluasan jumlah sampel dan pengumpulan data melalui wawancara.
Perilaku Pencarian Informasi Remaja Wanita Dalam Memenuhi Kebutuhan Informasi Skincare Melalui Media Sosial Twitter
Authors: Andayani Ulpah , Mutiara Adiesty , Arini Arini , Inayah Khoirani , Rafinia Riska , Faikar Muhammad , Nur Nur
Published: October 2023

Seiring berkembangnya zaman, informasi semakin mudah ditemukan. Sosial media sebagai contoh alat untuk menemukan informasi, dari aplikasi Twitter, Instagram, Pinterest, dan lainnya. Kemudahan mencari informasi mengenai skincare melalui media sosial Twitter yang dibarengi dengan perilaku seseorang yang gemar berbagi informasi mengenai skincare melalui review atau tweet memungkinkan untuk memenuhi kebutuhan informasi skincare bagi orang-orang yang mengakses Twitter karena sifatnya yang fleksibel yaitu dapat diakses dimana saja, kapan saja, dan oleh siapa saja. Penelitian ini menggunakan metode kualitatif karena peneliti ingin menjelaskan bagaimana pola perilaku pencarian informasi yang dilakukan oleh para pengguna skincare dalam memanfaatkan twitter untuk mencari informasi skincare. Metode pengambilan data yang akan digunakan adalah wawancara dan studi literatur. Informasi-informasi utama yang dicari oleh para remaja wanita mengenai skin care adalah produk skincare, jenis dan fungsinya, bahan dan kandungan skincare serta efek dari penggunaan skincare. Berdasarkan penelitian yang sudah dilaksanakan perilaku pencarian informasi yang dapat ditemukan pada remaja wanita adalah perhatian pasif, pencarian pasif, pencarian aktif dan pencarian berlanjut.
Strategi Pengelola Dalam Meningkatkan Pelayanan di Masa Pandemi Covid-19:Studi Kasus di Perpustakaan Universitas Katolik Musi Charitas Palembang
Authors: Anesia Adesti Putri , Misroni Misroni
Published: October 2023

Penelitian ini berjudul “Strategi Pengelola Dalam Meningkatkan Pelayanan Di Masa Pandemi Covid-19 (Studi Kasus Perpustakaan Universitas Katolik Musi Charitas Palembang”. Penelitian ini bertujuan untuk mengetahui apa saja bentuk pelayanan yang diterapkan oleh pengelola perpustakaan, untuk mengetahui strategi apa yang diterapkan pengelola perpustakaan dalam meningkatkan pelayanan di perpustakaan, dan untuk mengetahui apakah ada kendala yang dihadapi pengelola perpustakaan dalam meningkatkan pelayanan di Perpustakaan Universitas Katolik Musi Charitas Palembang. Dalam penelitian ini, penulis menggunakan penelitian deskriptif dengan pendekatan kualitatif. Pengambilan data diambil dengan menggunakan cara observasi, wawancara dan dokumentasi. Informan dalam penelitian ini adalah kepala perpustakaan, staff bagian layanan sirkulasi, staff pengelola bagian referensi dan student staff. Berdasarkan dari hasil analisis mengenai strategi pengelola dalam meningkatkan pelayanan di masa pandemi covid-19 (Studi kasus Perpustakaan Universitas Katolik Musi Charitas Palembang) dengan menggunakan analisis SWOT, hasil dari penelitian ini menunjukan bahwa bentuk pelayanan yang diterapkan pengelola perpustakaan dalam masa pandemi covid-19 ialah, menerapkan pelayanan online untuk sistem peminjaman, pengembalian dan perpanjangan koleksi di perpustakaan.
Pemetaan Subyek Penelitian Pada Skripsi Mahasiswa Fakultas Kedoteran UIN Syarif Hidayatullah Jakarta
Authors: Lolytasari Lolytasari , Hayati Nurul
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pemetaan subyek skripsi mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta. Metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kuantitatif.  Populasi dalam penelitian ini adalah skripsi mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta tahun 2019 - 2022 yang berjumlah 343 judul skripsi. Keseluruhan populasi tersebut diambil sebagai sampel penelitian. Hasil penelitian ini menunjukkan bahwa keragaman subjek dari skripsi yang telah dihasilkan mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta sebanyak 27 subyek. Dari 27 subyek tersebut, diketahui bahwa subyek yang paling banyak diteliti oleh mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta adalah penyakit  yaitu sebesar 37 % (126 judul skripsi); subyek yang paling sedikit diteliti adalah anatomi, sitologi, histologi manusia, Kedokteran forensik; insidensi cedera, luka, penyakit, kedokteran preventif publik, Bedah, kedokteran, Ginekologi, obstetrik, pediatrik, geriatrik yaitu masing-masing sebesar 3 % (masing-masng 10 Judul skripsi), serta Kedokteran dan Kesehatan sebesar 2% (6 judul skripsi). Sementara itu, tidak ada subyek  di dalam bagan Dewey Decimal Classification (DDC) yang belum pernah diteliti oleh mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta.
Perkembangan Publikasi UIN Syarif Hidayatullah Jakarta Terindeks Scopus Tahun 2019-2021
Authors: Andayani Ulpah
Published: October 2023

Salah satu tugas utama perguruan tinggi adalah mengembangkan dan menyebarluaskan ilmu pengetahuan yang dihasilkan melalui kegiatan riset.  Hasil-hasil riset karenanya harus dipublikasikan melalui saluran-saluran komunikasi ilmiah yang dapat diakses oleh masyarakat luas. Tulisan ini bertujuan melakukan evaluasi terhadap publikasi internasional UIN Syarif Hidayatullah Jakarta terindeks Scopus pada periode 2019-2021. Dengan menggunakan metode kuantitatf, publikasi dosen UIN Syarif Hidayatullah dipetakan berdasarkan tingkat produktifitas publikasi dan sitasi yang dihasilkan.  Hasil penelitian menunjukkan bahwa telah terjadi peningkatan jumlah publikasi internasional terindek Scopus pada kurun waktu tiga tahun sebanyak 205 publikasi dengan 580 sitasi yang menunjukan adanya keseriusan Lembaga untuk menjadi salah satu universitas berkelas dunia.
Dispositional optimism, coping strategies and the emotional state of parents of children with nocturnal enuresis
Authors: Kalicka Joanna , Kwissa-Gajewska Zuzanna , Rustecka Agnieszka
Published: October 2023

Introduction and objective: The subject of the article concerns the role of optimism in coping with stress and the emotions experienced by the parents of children suffering from nocturnal enuresis. The aim of the study was to determine the relationship between coping strategies and emotions experienced by the parents of children with nocturnal enuresis, taking into account the moderating role of optimism. Materials and methods: The study included 70 parents of children experiencing nocturnal enuresis, who were patients of the Department of Paediatrics, Paediatric Nephrology and Allergology of the Military Institute of Medicine – National Research Institute in Warsaw. The participants completed a sociodemographic survey and questionnaires measuring the level of dispositional optimism (Life Orientation Test-Revised, LOT-R), strategies for coping with a stressful situation related to the child’s illness (Coping Inventory for Stressful Situations, CISS-S) and the level of positive and negative emotions (Skala Uczuć Pozytywnych i Negatywnych, SUPIN, S30 – Polish adaptation of the Positive and Negative Affect Schedule, PANAS). The results of the research partially confirmed the assumed hypotheses. Results: A relationship was found between the level of optimism and emotions, and the use of task-focused coping strategies. The relationship between the level of optimism and other strategies could not be confirmed. Also, it has not been proven that all stress coping strategies are associated with negative and positive emotions. Contrary to the assumptions, optimism did not moderate the relationship between coping with stress and emotions, except for one case, namely coping strategies focused on emotions and the level of negative emotions. Conclusions: The obtained results allow to conclude about the prevailing role of the situational context – the child’s illness over personality variables.
Molecular characteristics of carbapenem-resistant Raoultella ornithinolytica
Authors: Sun Xicai , Wang Yugang , Wang Xuesong , Wang Honggang
Published: October 2023

Aim of this study was to explore molecular characteristics and resistance mechanisms of carbapenem-resistant Raoultella ornithinolytica (CR-ROR) isolated from patients in a hospital in China. Three CR-ROR strains were collected and bacterial identification was done by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) Vitek-MS and by digital DDH analysis. VITEK 2 compact system and Kirby-Bauer (K–B) disk diffusion were used for antimicrobial susceptibility testing. Whole genome sequencing was carried out using the Illumina platform NovaSeq sequencer. Abricate software was used for the prediction of antibiotic resistance genes of three CR-ROR strains. The phylogenetic tree was constructed through genome SNPs to investigate the genetic relationship of three CR-ROR strains. Three CR-ROR (WF1357, WF2441, and WF3367) strains were collected in this study. Two strains were isolated from neurosurgery (WF1357 and WF2441), and one was isolated from pulmonology department (WF3367). All strains harboured multiple antibiotic resistance genes. Two strains (WF1357, WF2441) carried the blaNDM-1 gene, one of the strains (WF3367) carried the blaKPC-2 gene. Three CR-RORs were resistant to different antimicrobial agents including carbapenems. The three CR-ROR strains collected in this study and 51 CR-ROR strain genomes downloaded from NCBI, were divided into six evolutionary groups (A-F). In this study, three CR-ROR strains were found to have a higher level of resistance to antibacterial agents and carried multiple antibiotic resistance genes. The CR-ROR strains carrying multiple antibacterial resistant genes require the stringent monitoring to avoid the spread of multidrug-resistant bacterial strains.