bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinant Factors to Intention of Halal Certification in Indonesia
Authors: Handayati Puji , Rochayatun Sulis , Meldona  , Jalaludin Ahmad , Bidin Rosmiza
Published: July 2023

Purpose:  The purpose of this study is tho exemine the influence of the knowledge of MSMEs owners about halal and religious certification on the intention to obtain halal certification which is mediated by the attitude of MSME owners.
 
Theoretical framework: The relationship between the knowledge of MSMEs owners about halal certification and religiosity to obtain halal certification can be mediated by the Theory of Planned Behavior. This theory focuses on the behavior of MSME owners to obtain halal certification. This is influenced by the knowledge of UKM owners about halal certification, religiosity, and the attitude of MSME owners in East Java.
 
Design/Methodology/Approach:  The research used a quantitative approach with a sample of 140 MSME owners in East Java, Indonesia. The data were analyzed using Structural Equation Modeling (SEM).
 
Findings: The results showed that the knowledge of MSME owners about halal certification and religiosity influenced the intention to obtain halal certification. The attitude of MSME owners in East Java can mediate the relationship between MSME owners' knowledge of halal certification and religiosity to obtain halal certification.
 
Research, practical & social implications: This study aims to encourage the intention of MSME owners to obtain halal certification by using the Theory of Planned Behavior (TPB) approach. According to the Theory of Planned Behavior, East Java UMKM owners will follow halal certification because of their mindset which is shown by their desire for it.
 
Originality/Value: Examine the role of the attitude of the MSME owner in mediating the relationship between the knowledge of the MSME owner about halal certification and religiosity on the intention to get halal certification by implementing the Theory of Planned Behavior.
How Hospitality Entrepreneurs Change Business Practices Under COVID-19 Pandemic: A Case Study of Small and Medium Sized Entrepreneurs at Lower Northeastern Thailand
Authors: Suvittawat Adisak
Published: July 2023

Purpose: The purpose of this study is to examine the adaption methods of hospitality entrepreneurs during the Covid-19 pandemic and the influenced variables for business adaptations.
 
Theoretical framework: This study was fundamentally based on the theory of entrepreneurial bricolage behavior which find to understand the entrepreneurs do during the resource constraints due to the covid-19 pandemic.
 
Design/Methodology/Approach: The quantitative study is using questionnaires as a tool. The methods of adaptation for innovative hospitality management used by small and medium size hospitality entrepreneurs in Lower Northeastern Thailand. The sample population included 360 individuals with 55% females and 45 % males. Most of the participants were owners (89%) of small hotels and guesthouses some with restaurants and other hospitality facilities such as spas and coffee shops.
 
Finding: An entrepreneurial adaptation of cost reductions in terms of facilities and personnel, as well as renegotiation with all stake holders including the government, that assisted far less in developing economies (EMDEs) and emerging markets then in European countries.
 
Research, practical and social implications: The methods discussed in the paper includes: adjustment in investment deferral; adjustment in effective cost reduction; reduce operating costs; management inventory downsizing; concentrate on innovation; negotiating the terms of various contracts; adjustment in getting help from the government and concentrate on activities that generate income for business.
 
Originality/Value: The value of the study is the adaptation is something constructed or created from a diverse range of available things. It introduces the information for small and medium size hospitality business adaptation during the crisis which effects the business operations. Most of the entrepreneurs will apply the adaptational variables for business sustainability and improve business performance.
The Influence of Service Quality, Customer to Customer Interaction, Staff Warmth, Staff Competence and Interaction on Intention to Recommend: Case Study at a English Language Institute in Indonesia During the COVID-19 Pandemic
Authors: Achmadi Hendra , Sembel Jacquelinda Sandra , Bernarto Innocentius
Published: July 2023

Purpose: The purpose of this study is to examine whether staff warmth and Competence and Customer to Customer interaction and service quality has positive influence to intention to recommend at a English Language Institute in Indonesia.
 
Theoretical framework: The theoretical framework is conduct with service quality, staff warmth and competence and customer to customer interaction, that has empirical study before which influence to intention to recommend.
 
Design/Methodology/Approach: This research is a quantitative method and individual unit analysis and was conducted using Structured Equation Method (SEM) with Smart PLS 3.2.9 and the number of respondents was 152 respondents from students studying at LIA.
 
Findings: The Service quality and staff warmth and competence and customer-to-customer interaction have a positive effect on the intention to recommend by 70.1%. Customer to customer interaction that influence the intention to recommend is the highest value of 32,8 % and also the staff warmth and competence has the second highest value of 31,2 %.
 
Research, practical and social implications: The study found that customer to customer interaction has significantly influence the intention to recommend, so the institute has to control especially for the negative issues, and also the institute has to increase the capability from the staff and the lecturer.
 
Originality/Value: The value of the study, at digital era especially in pandemic, the value tangible factor is very low, but the value of the staff warmth and competence and also customer to customer interaction is very high, because the customer is very easy to interact with other using digital platform.
Impacts of Economic Development on the Living Conditions of Ethnic Minority People in the Border Region of Northern Vietnam
Authors: Truong Bao Thanh , Nguyen The Kien , Nguyen Thi Thu Ha , Nguyen Thi Hanh , Nguyen Thi Thanh Tam , Nguyen Dinh Quynh
Published: July 2023

Purpose:   In this study, we examine the effects of the economic development policies of the Vietnamese government on the living conditions of ethnic minority people in the border region of Northern Vietnam.
 
Theoretical framework: We examine the impact of economic changes, societal changes, and environmental improvements on the living conditions of ethnic minority people in the border region of Northern Vietnam.
 
Design/Methodology/Approach: The collected data was subsequently cleaned and analyzed using Partial Least Squares Structural Equation Modelling (PLS-SEM) with the aid of SPSS 20 software.  
 
Findings: The results show that the current Vietnamese government’s policies on developing agriculture, industry, trade, and service for ethnic minority people have a diverse impact on their living conditions. In general, agriculture, trade, and service are major fields that benefit the living conditions of ethnic minorities. In contrast, the industry seems to have no effects on improving the standard of living of ethnic minority people in Northern Vietnam.
 
Research, practical & social implications: The results of this study provide suggestion to Vietnamese government on promoting living conditions of ethnic minority people in the border region of Northern Vietnam.
 
Originality/Value: This is the first paper evaluates the impact of the economic development policies of the Vietnamese government on the living conditions of ethnic minority people in the border region of Northern Vietnam.
Human Resource Practices and Innovativeness: A Conceptual Paper
Authors: Aljenibi Nadia Nasser Abdullah , Kamarudin Mohd Fauzi Bin
Published: July 2023

Purpose: The purpose of this study is to review and produce a set of propositions about the function of human resource practises and innovativeness in a business environment.
 
Implications of research: Growing worldwide rivalry, extremely unpredictable markets, and even greater customer expectations have resulted as a result of the globalisation of the world, making it important for enterprises to be open to the possibility of innovation.
 
Findings: According to the findings of this research, a paradigm for understanding the relationship between human resource practises and innovativeness, as well as the moderating effect of innovation capability, is proposed.
 
Originality/Value: This document contains a series of propositions that constitute an empirically driven research agenda, as well as descriptions of the correlations between the focus variables that are given to improve the understanding of the audience in a business setting.
Urgency of Reform Asset Forfeiture Model of Narcotics Crime in Investigation
Authors: Siagian Kristian , Sulistiani Lies , Rusmiati Elis
Published: July 2023

Purpose:  The Narcotics Law as a foundation in law enforcement to eradicate illicit drug trafficking, is not effective enough in tackling narcotics crime, because the legal paradigm adopted in the narcotics law is oriented towards imprisoning the perpetrator (follow the suspect), while the assets resulting from narcotics crimes continue to be used for narcotics trafficking and distribution. The problem is what is the urgency of renewing the model of asset forfeiture from narcotics crimes? What is the ideal model of asset forfeiture from narcotics crimes?

 

Design/Methodology/Approach:  The research method used is a normative approach and empirical approach sourced from primary data and secondary data. Primary data is obtained by means of field studies and interviews while secondary data is obtained by means of literature studies. The data that has been collected is analyzed qualitatively.

 

Findings: The urgency of updating the model of seizure of assets resulting from narcotics crimes must receive attention in criminal law policy, this is because the current mechanism is not adequate and even tends to use assets as an instrument of illicit drug trafficking, which should be maximized for the rehabilitation of drug addicts and abusers. The future model of asset forfeiture in relation to the renewal of the investigation for asset forfeiture of narcotics crimes is a model of asset forfeiture without punishment. This model is known as in rem forfeiture, or also known as civil forfeiture, and NCB asset forfeiture. The NCB model is essentially a suit brought against assets, not against persons. The action is separate from the criminal court, but only determines that the assets have been tainted by the criminal offense.
Future Scenario of Faculty of Physical Education Thailand National Sports University in the Next Decade (2023-2032)
Authors: Chudam Wongphat , Khajornsilp Jirawat , Mahaniyom Sobsun
Published: July 2023

Purpose: To study the possible future scenarios in educational management of Faculty of Physical Education Thailand National Sports University in the next decade (2023-2032)

 

Theoretical framework: The educational management theory.

 

Design/Methodology/Approach:  EDFR (Ethnographic Delphi Futures Research) by utilizing a mixed-method research. In the quantitative phase was characterized by an initial quantitative phase of data collection by the questionnaire with 17 participants with the purposive sampling, and analyzed through Median and Interquartile Range. In the qualitative phase, the 17 experts participated in focus group, and analyzed by the content analysis.

 

Findings: The results of the quantitative phase identified the 9 aspects, and 80 components which were as follows; 1) Characteristics and competencies of graduates. 2) Curriculum and teaching and learning. 3) Research and innovation. 4) Administration. 5) Academic services.  6) Fostering art and culture. 7) Information technology. 8) Facility. 9)  Excellence in sports. The qualitative data verified the result from the quantitative phase, and confirmed that the research result can be practiced in the real life situations.

 

Research, practical & social implications: The study can be used for being as the guildline of the possible future scenarios in educational management of Faculty of Physical Education Thailand National Sports University in the next decade (2023-2032)

 

Originality/Value: The value of the study can apply for creating the action plan of the Thailand National Sports University action.
Designing Novel, Valuable, and Marketable Products from Waste Sedge Plant Fiber Residues
Authors: Roadkasamsri Vuthipong , Teekalee Apiched , Sungvondee Arnon , Li Yingfeng
Published: July 2023

Purpose:  The purpose of this study is to examine how discarded sedge plant fibers can be converted into new market-oriented products through product design and development. 

 

Theoretical framework: The product design and development method, researchers work directly with the community as partners to experiment with materials using simple technology and design prototypes. The goods were then evaluated for market viability and SWOT to determine if they met market demands. These techniques target novel, collaborative, value-added, and waste goods.

 

Design/Methodology/Approach: The mixed-methods case study followed Community-Based Participatory Research (CBPR). Market assessments provided quantitative data. The community business served 140 Baby Boomers and Gen Z customers, ages 20–50, and sampled 103 consumers. The data collection instruments included site surveys, interviews, focus groups, experiments, recordkeeping, surveys, and SWOT analysis.

 

Findings: This study identifies uniquely developed products that are ecologically conscious and reduce global impacts. The value of waste sedge plant fibers from the production of reed mats can be added, redesigned, and developed into marketable products. The two prototypes (the Bannock basket and the berry basket) met market demand in terms of material suitability, uniqueness and attractiveness, competitive price, commercial possibilities, exquisiteness, and utility. The SWOT analysis revealed potential marketing opportunities for the developed products. 

 

Research, practical and social implications: The study reveals these significant implications. Practically, this study offers alternatives to traditional methods that can be used to overcome the current economic and environmental barriers to reducing waste and getting more value out of it. Conceptually and methodologically, it offers a technique to rebuild the framework of product design and development from waste sedge plant fiber remnants into new, value-added, and market-oriented products. Socially, this study yields the production process knowledge transfer to community levels nationwide. Economically, the developed products implicate viability of community-level OTOP establishments nationally.

 

Originality/Value: This is the first time that the waste sedge plant fibers from the production of reed mats have been designed and developed into marketable products. This research is part of a paradigm shift in redesigned product design and development that is critical for the economic and environmental sustainability of communities.
DEVELOPMENT OF TECHNOLOGY FOR CREATING ENVELOPING PORRIDGE WITH ADDITION OF BURDOCK LEAVES (ARCTIUM LAPPA L.)
Authors: G.E. Bokarev , N. V. Nesterova , T.V. Korochkina , N.V. Birykova , E.O. Birykova
Published: July 2023

Currently, an important and promising area of scientific research is the development of functional nutrition products that combine traditional nutritional value with components that provide a comprehensive and therapeutic and preventive effect. Taking into account the experience of folk medicine in the use of burdock leaves as a component of food products (soups, salads), as well as scientific literature data characterizing a wide range of pharmacological activity of this medicinal plant raw material, provided with the content of biologically active substances such as polysaccharides, flavonoids, phenol carboxylic acids, carotenoids and chlorophyll, the authors proposed the use of leaves burdock is used as components of a functional food product – enveloping porridge. The authors present the results of developing a recipe for enveloping porridge with the addition of burdock leaves. As a result of this work, a technological map was created for the production of enveloping porridge based on oatmeal with the addition of burdock leaves, which can be included in the therapeutic and preventive diet of patients in need of dietary nutrition. The authors conducted a primary examination of the organoleptic characteristics of the dry product, as well as the finished porridge obtained on its basis. Also, during the expert evaluation of the received product, the sensory profile of the proposed sample was obtained.
COMPARATIVE ANALYSIS OF THE COMPOSITION AND QUANTITATIVE CONTENT OF ANTHOCIANS IN THE FRUITS OF CRANBERRIES (VACCINIUM OXYCOCCUS L.) AND LARGE-FRUITED (VACCINIUM MACROCARPON AIT.)
Authors: V.Yu. Ermakova , A.A. Luzin , D.A. Dobrokhotov , G.V. Nesterov , I.N. Avertseva , V.Yu. Reshetnyak
Published: July 2023

The authors carry out a comparative analysis of the fruits of the common cranberry, used in the Russian Federation as food and medicinal raw materials, and the fruits of the large-fruited cranberry, which is the most cultivated species, the cultivation of which began in the 19th century in Canada and the United States, and in Russia has been widely spread since 1980. An important group of biologically active substances in cranberry fruits is undoubtedly anthocyanins [5], which have a pronounced antioxidant activity, help strengthen the walls of blood vessels, stimulate the processes of protein biosynthesis, and have a stimulating effect on reparative processes. In vitro and in vivo experiments revealed that anthocyanin pigments can significantly reduce the rate of cancer cell division. HPLC method established the presence of anthocyanins in the fruits of common and large-fruited cranberries. In the composition of the anthocyanin fraction of all the studied samples, peonidin-3-arabinoside was identified, the presence of which makes it possible to reliably identify cranberry fruits and their processed products. The total amount of detected anthocyanin pigments ranges from 0.17% (1.31% by weight of absolutely dry raw materials) in fruits of fresh common cranberries to 0.27% (1.64% by weight of absolutely dry raw materials) in fruits of large-fruited cranberries of the Mack variety -Farlin The observed differences can be associated with both ecological and geographical factors, i.e. the difference caused by the harvesting of raw materials in different places where cranberries grow, and the season of harvesting fruits for analysis, which undoubtedly requires additional study of cranberry fruits from different regions of harvesting and harvesting time and will be continued in subsequent studies. The authors also found that during the preservation of cranberries by freezing, the content of anthocyanins decreases, which makes it possible to recommend the maximum processing of fresh raw materials.
MARKETING RESEARCH OF THE RUSSIAN PHARMACEUTICAL MARKET OF FOOD PRODUCTS WITH ADDED MILK PROTEINS
Authors: A. I. Radchenko , G.V. Varenykh , E.V. Kuzubova , N.V. Grigorenko , U.A. Krut , М.V. Korokin
Published: July 2023

A marketing study of the Russian pharmaceutical market of food products with the addition of milk proteins was carried out. The study revealed that the leading position in the Russian pharmaceutical market is occupied by products for artificial nutrition, which is 37.91%; diet food - 29.95%; in the form of soy-protein cocktails - 7.11%; for sports nutrition - 5.69%; complementary foods - 5.69%. Other food products with the addition of milk proteins account for 13.74% of the total assortment. In particular, the smallest amount is occupied by products for medical nutrition intended for children with phenylketonuria aged from 1 year - 0.47%; protein-energy cocktails to support a weakened body - 1.42%; specialized products of children's dietary (therapeutic) nutrition for children from 0 to 1 year old, patients with type 1 glutaric aciduria - 2.36%.
HEART RHYTHM AND CONDUCTIVITY DISTURBANCES IN MALES UNDER 50 YEARS OLD WITH CARDIOGENIC SHOCK DURING MYOCARDIAL INFARCTION
Authors: A.V. Golikov , D.R. Kulikov , G.A. Alper , D.V. Nosovich , A.V. Duganova
Published: July 2023

Relevance. Cardiogenic shock remains one of the most common causes of death in myocardial infarction.
Aim. To evaluate the features of cardiac rhythm and conduction disturbances in myocardial infarction complicated by cardiogenic shock, as well as their significance for the development of this complication in males under 50 years old to improve prevention and outcomes.
Material and methods. The study included males aged 19-49 years old with type I myocardial infarction. The patients were divided into age- comparable groups. The study group consisted of seven patients with cardiogenic shock, the control group - without cardiogenic shock - 223 patients. A comparative analysis of arrhythmias among the variants of the clinical course, complications, as well as their structure in selected groups were performed. The influence of the studied parameters on the risk of cardiogenic shock development in the examined patients was assessed by the method of risk analysis using the Pearson Chi-square test.
Results. In the study group, a higher incidence of arrhythmias in the structure of MI complications (85.7%) was revealed than in the control group (24.2%; p=0.003). They were observed in combination with complications of the group of contractile myocardial insufficiency and its mechanical failure (57.1% and 6.3%, respectively; р˂0.0001) and only contractile insufficiency (28.6% and 11.2%; р˂0,0001). In the structure of arrhythmias in the study group, the frequency of observation of atrial fibrillation and flutter (66.7%) prevailed over the control group (4.9%; р˂0.0001), ventricular fibrillation (50.0 and 2.4%, respectively; р˂ 0.0001), supraventricular tachycardias (33.3% and 1.5%; р˂0.0001), supraventricular (33.3% and 8.3%; р=0.03) and polytopic extrasystoles (33.3% and 3 .9%; p=0.0003), ventricular tachycardias (16.7% and 2.0%; p=0.02), complete atrioventricular blockades (16.7% and 2.0%; p=0.02) and asystole (16.7% and 1.5%; p=0.007). The risk of cardiogenic shock development increased with these arrhythmias.
Conclusions. The listed types of arrhythmias should be used in the formation of high-risk groups for the cardiogenic shock development in myocardial infarction for monitoring and timely implementation of the necessary treatment. It is also expedient to take them in the prognostic modeling of this complication.
THE DEVELOPMENT OF INTRATUMORAL IN SITU IMPLANT WITH BERBERINE BISULPHATE
Authors: E.O. Bakhrushina , E.D. Moiseev , A.A. Moiseeva
Published: July 2023

Berberine (BB) is an isoquinoline alkaloid, which is obtained from Berberis (Barberry), more often Berberis vulgaris, of the Berberidaceae family. The interest of the scientific community in this molecule was caused by its vast number of pharmacological effects: antitumor, hypolipidemic, anti-inflammatory, antiarrhythmic, antidiabetic, etc.
The antitumor effect of BB consists in the inhibition of the cell cycle in the G1 phase, the induction of apoptosis in tumor cells, the effect on mitogen-activated kinases, and the suppression of metastasis. The main reason for the infrequent use of this molecule is its poor solubility and low bioavailability. Thus, the best solution to overcome these problems is intratumoral implantation.
During the analysis of scientific publications, it was found that in the process of developing intratumoral implants when creating matrices with various active substances, it is most often preferred to use poloxamers, since the temperature stimulus is the most characteristic and reliable in therapy.
Thus, the aim of the study is to develop the composition and technology of an intratumoral thermosensitive implant of berberine bisulfate (BBB).
The study used 101.6% BBB substance (Vifitech, Russia). Kolliphor® P188, Kolliphor® P338, Kollisolv® P124 and Soluplus®, polysorbate-80, PEG-1500 (BASF, Germany) were used as solubilizers. N-methylpyrrolidone was also considered as a candidate for dissolution media.
Solubilization of BBB was carried out by adding surfactants and their combinations, by the method of solid dispersions, liquid-liquid extraction. BBB showed very low solubility in N-methylpyrrolidone. The final composition contained Kolliphor® P 407 (15.0%), Kolliphor® P 188 (2.0%), Kollisolv® P124 (2.0%), BBB (1.3%) with a phase transition rate of 2 minutes and phase transition temperature 37-38℃.
For the obtained optimal composition, the “Dissolution” test was carried out using a dialysis bag, in a phosphate buffer solution pH 6.8, at a constant temperature of 37℃. Sampling was carried out after 1 hour, 2 hours, 3 hours, 5 hours, 24 hours and 96 hours. The concentration of the substance was determined using spectrophotometry.
As a result of the studies carried out, the most suitable composition for an intratumoral implant was created, and the necessary tests were carried out. It can also be concluded that the use of poloxamers is effective in improving the dissolution of BBB. Further research is required.
COMPARATIVE ANALYSIS OF APPLIED METHODS OF PHYSIOTHERAPEUTIC TREATMENT OF GLOSSALGIA
Authors: E.G. Borisova , K.K. Bogacheva , A.S. Zhukova , D.A. Khlebnikov , E.M. Burtseva
Published: July 2023

Glossalgia is a chronic disease, the main manifestation of which is pain, characterized by burning and tingling, and, most often, not accompanied by lesions of the oral mucosa and tongue. According to most researchers, the disease is considered polyetiological, as it occurs against the background of concomitant pathologies of various systems and organs, such as damage to the central and peripheral nervous system, disruption of the gastrointestinal tract, endocrine disorders (diabetes mellitus, menopause), diseases of the cardiovascular and circulatory system, as well as the presence of inflammatory and traumatic factors in the oral cavity (traumatization of the oral mucosa by elements of dentures, sharp edges of teeth, dysfunction of the temporomandibular joint). The article is devoted to a comparative analysis of approaches in the treatment of glossalgia by a dentist over the past few years: treatment tactics, what is their effectiveness and what does not lead to positive results with a high proportion of relapses. The topic of glossalgia treatment is relevant, because it is widespread and concerns not only dentists, but also doctors of other specialties: neuropathologists, endocrinologists, therapists, gastroenterologists, psychiatrists. To date, there are many research works of domestic and foreign authors who have devoted their works to this disease. Currently, there are many methods aimed at symptomatic elimination or weakening of paresthesia through medications and instrumental methods of treatment. However, they do not always give a stable therapeutic effect and often their use is accompanied by a number of adverse reactions in the body. The approach to therapy should consist in the complex and systematic use of therapeutic agents, consisting of measures to eliminate pathological foci, medications, physiotherapy, massage, spa treatment of concomitant somatic diseases, compliance with the regime of work and rest and creating a psychologically favorable atmosphere in the environment. To achieve the greatest effectiveness in treatment, the patient should be examined not only by a dentist, but also by doctors of other profiles. In the course of the study, an analysis of the physiotherapeutic methods of treatment of glossalgia was carried out, using tabular and graphic images, in order to identify the most effective treatment tactics within the framework of a dental appointment.
EXPRESSION OF ENDOTHELIAL DYSFUNCTION AS OBJECTIVE CRITERION OF SEVERITY OF PREECLAMPSIA
Authors: Yu.V. Mikhailova , M.S. Shekhter
Published: July 2023

Preeclampsia remains one of the most significant obstetric problems due to its high prevalence, high incidence of maternal and perinatal morbidity and mortality, as well as the need for significant economic costs for the management and delivery of pregnant women with this pathology.
In recent years, a number of authors have proven the most important role of vascular endothelial dysfunction in initiating disorders of vascular tone and blood coagulation potential, which underlie the formation of multiple organ failure in pregnant women with preeclampsia.
The aim of the study was to establish new objective criteria for assessing the severity of preeclampsia based on the study of the functional state of the vascular wall by various methods, both invasive and non-invasive.
118 women with 28-37 weeks of pregnancy were examined. The 1st observation group consisted of 58 pregnant women with moderate preeclampsia, the 2nd observation group included 20 pregnant women with severe preeclampsia. The control group consisted of 40 women with a physiological course of pregnancy.
The functional activity of the vascular wall was assessed by the level of endothelin-1, thrombospondin, intercellular adhesion molecules and nitric oxide metabolites in the blood by enzyme immunoassay.
In patients with moderate preeclampsia, the content of nitric oxide metabolites significantly decreased, and the content of endothelin-1, thrombospondin, and intercellular adhesion molecules increased relative to patients in the control group. These changes were significantly more pronounced in patients with severe preeclampsia.
At the same time, to study the function of the endothelium in pregnant women with preeclampsia, we used a non-invasive method - an ultrasonic cuff test according to the Celermajer D.S.
In patients with moderate preeclampsia, the degree of endothelium-dependent arterial expansion during the cuff test decreased by more than 2 times compared with the parameters of pregnant women in the control group. In pregnant women with severe preeclampsia of the group, an even more pronounced decrease in the degree of dilatation of the brachial artery was noted.
Thus, the determination of markers of endothelial dysfunction in the blood, as well as the use of an ultrasonic cuff test, made it possible to identify violations of the vasomotor function in pregnant women with preeclampsia, which correlate with the severity of preeclampsia.
The use of an ultrasonic cuff test and the determination of endothelial dysfunction markers can be recommended as additional objective diagnostic criteria for the severity of preeclampsia, the transition from moderate preeclampsia to severe preeclampsia.
QUALITY AS THE MAIN FACTOR OF COMPETITIVENESS IN THE DENTAL SERVICES MARKET
Authors: V.V. Shkarin , T.A. Sinenko
Published: July 2023

The article considers the main aspects related to the quality of dental services as one of the main factors of competitiveness in market conditions. The problem of the quality of dental services is considered both from the point of view of the organizations providing them, and from the point of view of consumers. The complex nature of the category of quality of dental services has led to consideration in this work of such important aspects as: levels of formation of the quality of dental care; key criteria for quality assessment; the main factors affecting the quality of dental services. It is proved that the interest in the issue of quality improvement is due not only to the importance of the victory of organizations in the competition for customers, but also to the nature and high level of legal conflict situations arising in this area. The key success factors of both internal and external nature have been identified, which allow in the long term to provide the necessary level of competition to the dental clinic. The article focuses on the fact that each organization, adapting to changes in the external environment, should make maximum use of all available opportunities that make up its potential: highly qualified medical personnel, modern materials and innovative technologies, an effective management system. The author gives a detailed description of the conditions that can affect the level of use of the organization's potential, and hence the quality of services provided. The main methodo-logical approaches to assessing the quality of dental services are considered. One of the assessment tools adapted to the conditions of medical dental services is the multidimensional SERVQUAL methodology, designed to take into account the consumer's expectations and perception of the service in five dimensions. Its advantages are revealed, namely, the ability to understand how the patient perceives the dental service, and how it is evaluated in real use.
ANALYSIS OF THE INFORMATION BASE OF RESEARCH ON THE ISSUES OF DRUG SUPPLY
Authors: G.S. Barkaev , T.I. Kabakova , A.B. Goryachev , E.A. Korzhavykh , M.A. Garumova
Published: July 2023

The purpose of this study was to identify and analyze the composition and structure of the information base of pharmaceutical research on the problems of drug supply of the population, as a field of scientific, practical and educational knowledge. The experimental base of the study was the lists of references for dissertations on the problems of drug supply of the population for the period 2015-2022, including: 4 dissertations for the degree of candidate of pharmaceutical sciences and 4 doctoral dissertations. The indicated experimental base was formed by the method of random non-repetitive selection and amounted to about 32% of the total number of dissertations on this issue in the specified period. Statistical (grouping), structural, comparative and scientometric analyzes were used as the scientific and methodological apparatus of the study. The research methodology included three stages: 1) formation of an array of bibliographic references from selected reference lists; 2) grouping of bibliographic descriptions in accordance with classification features; 3) analysis of the grouping results from the standpoint of reliability and expediency of using information sources. The information base, prepared on the basis of the lists of references of selected dissertations on this topic, included 1910 literary sources. As a result, using the basic provisions of science of science, the dynamics of the composition and structure of the information base on the problems of drug supply has been studied. The possibility of assessing the quality of scientific research (reliability criterion) based on the structural analysis of its information base is shown. A structural model of the drug supply information base has been formed, which is a hierarchical system of types, classes and types of information sources. The results of the study make a theoretical and methodological contribution to pharmaceutical knowledge, and also allow you to directly and visually assess the quality of the literature worked out by the dissertator on the topic of work and the design of the list of references for the research (dissertation) work according to the criterion of compliance with the requirements of regulatory documents, the reliability of the study itself - indirectly, according to the criterion of compliance of sources with existing requirements, and also indicate the need to educate scientists in the responsibility for proper citation of the sources of information used.
NEW TREND: ELECTRONIC NICOTINE DELIVERY SYSTEMS
Authors: A.V. Tkachenko , T.A. Slinkova , L.N. Shipkova
Published: July 2023

Since the end of the 20th - beginning of the 21st century, there has been a significant decrease in the number of smokers in the world. Almost simultaneously, a new trend is being formed - the introduction of electronic nicotine delivery systems (ENDS, vapes). Vapes, declared by manufacturers as a safe alternative to tobacco smoking, are nevertheless little studied in terms of their effect on the human body. In this work, we have studied various types of smoking systems, and also performed an instrumental analysis of excipients for EDSN. The main types of ENDS are described - disposable, reusable, serviced and unattended, novelties of recent years - iQOS and Glo™. Samples of disposable ENDS with and without nicotine were studied by GLC with computer processing of the results. The content of glycerin, propylene glycol, nicotine was determined. Several samples contained trace amounts of acrolein and ethylene glycol not reported by the manufacturers. The biological effect of ENDS components and the consequences of their use are described.
STABILITY OF ORTHODONTIC TREATMENT RESULTS IN PATIENTS LIVING IN RADIONUCLIDE-CONTAMINATED REGIONS
Authors: V.D. Klurfeld , A.V. Sevbitov , A.V. Timoshin , M.Yu. Kuznetsova
Published: July 2023

The 1968 accident at the Chernobyl Nuclear Power Plant led not only to significant environmental changes, but also to a deterioration in the health and quality of life of the population living in radiation-contaminated areas, including an increase in the number of complex dental anomalies requiring orthodontic treatment. In the decades that have passed since the accident, the authors have conducted studies of the effect of radiation on the body as a whole, but the question of the effect of radiation on the dentition remains insufficiently studied. The aim of our study was to determine changes in the level of secretory parameters of gingival fluid in patients in the retention period after active orthodontic treatment. It was found that the restoration of the level of immunoglobulins and interleukins to normal values in patients living in radiation-contaminated areas requires a longer time compared with the same parameters in patients of the control group. In this regard, such patients may be recommended moderate or permanent retention of the results of orthodontic treatment to prevent relapses of dental anomalies. We believe our results will support the development of a differentiated system for orthodontic rehabilitation and follow-up of individuals exposed to radiation as a result of the Chernobyl accident.
RECOGNITION OF RESPONSIBILITY FOR ONE'S OWN HEALTH AS A FACTOR SHAPING PATIENT BEHAVIOR
Authors: A.V. Martirosov , S.N. Cherkasov , A.V. Fedyaeva , G.B. Arutyunyan
Published: July 2023

The purpose of the study. To scientifically substantiate the importance of a responsible attitude to one's own health as a social factor shaping the patient's behavior. Materials and methods of research. The primary data were obtained by interviewing 502 patients of medical organizations providing outpatient medical care. The main group consisted of 420 patients who recognized primary responsibility for their health (active behavior model), the control group consisted of 82 patients who assigned primary responsibility for their health to external subjects (passive behavior model). Results. Patients who take responsibility for their health are less likely to give up the right to choose a doctor, they are more demanding of the professional qualities of a doctor, attention (as a manifestation of a professional approach) and kindness as a manifestation of a human approach are more important to them. However, they are less interested in sympathy from the doctor. The most important criteria for choosing a medical organization that provides outpatient medical care were the availability of competent specialists and the reputation of the medical organization, which were of greater importance among patients who consider themselves primarily responsible for their health. The patients were also interested in geographical accessibility and the quality of the organization of the medical care process.
ORPHAN DISEASES: REGULATION OF DRUG PROVISION FOR PATIENTS IN RUSSIA
Authors: R.Y. Garankina , I. F. Samoshchenkova , E.R. Zaharochkina , D. V. Kondratova , N Behorashvili
Published: July 2023

In conditions of budget deficit, the issues of drug provision for patients suffering from life-threatening and chronic progressive rare (orphan) diseases require constant monitoring by regulatory authorities. In this regard, the purpose of the work was to analyze the main aspects of the legal regulation of drug provision for persons with rare (orphan) diseases. The lack of funds in the regions which could fully meet the needs of patients with rare (orphan) diseases in the provision of medicines, served as a weighty argument for the launch of the state federal program for high-costnosologies and the centralization of public procurement of medicines. The key tool for improving drug care was the approval of lists of orphan diseases and the introduction of the federal register of patients eligible for preferential drug provision into the unified information and analytical healthcare system. An important and defining moment of federalization of procurement of medicines was the creation of a federal state institution under the Ministry of Health "Federal Center for Planning and Organization of Drug Provision for Citizens". The main additional mechanism and alternative solution for providing medicines to children under 18 with severe life-threatening and chronic diseases, including rare (orphan) diseases, was the charitable support fund "Circle of Good" created by presidential decree. The financial and organizational approach and the decision of the regulator to federalize the procurement of orphan medicines under the high-cost nosology program makes it possible to increase the equal availability of medicines to persons with rare (orphan) diseases in all subjects of the Russian Federation and to reduce the costs of budget allocations.
DETERMINATION OF ENALAPRIL MALEATE IN SUBSTANCE AND TABLETS BY METHOD OF GALVANOSTATIC COULOMETRY
Authors: S.G. Abdullina , E.A. Serebriannikova
Published: July 2023

Enalapril, belonging to the class of ACE inhibitors, is one of the leading drugs in the treatment of cardiovascular diseases and is used to treat essential hypertension of any severity, renovascular hypertension, heart failure and its prevention, as well as the prevention of coronary ischemia in patients with left ventricular dysfunction. Increasing requirements for the quality of pharmaceutical substances and pharmaceutical dosage forms create conditions for improving existing and creating new analytical developments performed using modern instrumentation. A promising method for quality control of pharmaceutical substances is the method of galvanostatic coulometry, in particular, coulometric titration with electrogenerated hydroxide ions, in which the main controlled parameters are time and current flowing through the electrochemical cell.
Electrogenerated hydroxide ions are formed during the electrolysis of water. As an electron carrier, sodium sulfate, potassium sulfate, and other salts are usually used. Currently, devices are being produced that allow you to measure these parameters automatically with high accuracy. Galvanostatic coulometry is distinguished by the simplicity of the experiment, rapidity, and accuracy. Does not require expensive equipment, preliminary standardization of the titrant, the use of standard samples (except for the determination of water by the Karl Fischer method). Electrogenerated hydroxide ions interact with enalapril maleate quickly and quantitatively in a ratio of 3:1. Unified methods have been developed for the quantitative determination of enalapril maleate in the substance and tablets by coulometric titration with electrogenerated hydroxide ions. The auxiliary components of the tablet mass do not interfere with the determination of the active ingredient. The relative standard deviation does not exceed 0.6%, the relative error of the mean does not exceed 0.8%. Methods can be used in the practice of control and analytical laboratories to assess the parameter "Assay" in the substance and tablets.
EVALUATION OF BIOPHARMACEUTICAL PARAMETERS OF A NEW INTRANASAL ANTIVIRAL DRUG BASED ON AN IN SITU SYSTEM
Authors: E.O. Bakhrushina , A.S. Ivkina , T.V. Tabanskaya
Published: July 2023

Intranasal antiviral administration is a modern method for delivery of both immunobiological and synthetic substances. This route in medication delivery has a number of advantages: it is non-ivasive, highly practical, bioavailable and provides protective immunity at the entry gates of respiratory infections. The problem of intranasal delivery systems is short drug retention time under the effect of mucociliary clearance that results into limited absorbtion and prolongation capability. Аnatomical structure of the nasal cavity as well as the effect of mucociliary clearance result into an early evacuation of the administered drug so the active substance is not fully delivered. The solution to the problem is the usage of in situ delivery systems with stimulus typical for nasal cavity applied: temperature, ionic composition, pH. These systems make a phase transition at the area of application with viscosity increase enough for continuous effect on the mucous membrane. Earlier an intrasal ribavirin delivery system has been designed at the Institute of Pharmacy named after A. Nelubin. Ribavirin is an active substance known for more than forty years, approved by the FDA and included in the clinical guidelines for the treatment of diseases caused by SARS-CoV-2. The purpose of that research was to define the main biopharmaceutical parameters of the designed composition. The delivery system included ribavirin (10 mg/ml), poloxamer 407 – 16%, chitosan formate – 4%.
The evaluation of biopharmaceutical characteristics was carried out according to the parameters рН, phase transition temperature, gelation time, viscosity, mucoadhesion and also spray torches, distribution area and retention on an in vitro model, releasing in the Franz cell test.
Results of the evaluation of indicators: pH of the system – 7,07±0,12; sol-gel transition end temperature 30,7±0,4℃; gelation time - 36±15 s; increase in viscosity after phase transition - 7 times; mucoadhesion - 8,6±1,5 Н; distribution area - 44,9±5,3 cm2; retention on an in vitro model - 85,0±3,5%. During the determination of the release of ribavirin, it was shown that in the first 5 minutes about 62.5% is released, then the release is gradual and by six hours it reaches 84.7%. Based on the obtained data, it can be concluded that the developed composition is potentially promising and that it can be further evaluated in preclinical studies.
A COMPREHENSIVE APPROACH TO THE TREATMENT OF BACTERIAL VAGINOSIS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME
Authors: O.B. Kalinkina , Yu.V. Tezikov , I.S. Lipatov , M.O. Mayorova , U.A. Rudenko , E.V. Zubkovskaya
Published: July 2023

A two-stage complex method of therapy of bacterial vaginosis (BV) in 29 patients with polycystic ovary syndrome (PCOS) is proposed, consisting in the use of standard metronidazole therapy (vaginal suppositories of 500 mg 2 times a day for 7 days) at the first stage and therapy with Acylact DUO at the second stage (1 candle in the vagina per night of 10 days), effective in relieving clinical manifestations and preventing recurrence of vaginal dysbiosis. Intravaginal administration of metronidazole to patients with polycystic ovary syndrome (PCOS) and bacterial vaginosis (BV) significantly reduced the concentration of anaerobic microorganisms. The appointment with Acylact DUO stimulated the growth of its own lactobacilli and helped to reduce the number of relapses of the disease by increasing the protective properties in the vagina. Normalization of the vaginal microflora was noted in all patients included in the study. After three months, normal vaginal biocenosis was detected in 26 patients (89.6% of women) according to a control smear study to detect key cells as markers of bacterial vaginosis. Clinical manifestations of bacterial vaginosis (itching, burning, pathological discharge) were not detected in any patient. Thus, the conducted study showed high efficiency of complex two-stage treatment of bacterial vaginosis, consisting in the use of vaginal candles containing metronidazole at the first stage, followed by the drug Acylact DUO in patients with polycystic ovary syndrome, provided timely correction of hormonal and metabolic disorders in them.