bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced PSHE based refractive index sensor using nanophotonic resonator
Authors: Goyal Amit Kumar , Divyanshu Divyanshu , Massoud Yehia
Published: May 2023

This manuscript presents a dielectric resonator structure with altered dispersion characteristics to enhance the photonic spin hall effect (PSHE). The structural parameters are optimized to enhance the PSHE at 632.8 nm operating wavelength. The thickness-dependent angular dispersion analysis is carried out to optimize the structure and obtain the exceptional points. The PSHE-induced spin splitting shows a high sensitivity to the optical thickness of the defect layer. This gives a maximum PSHE-based transverse displacement (PSHE-TD) of around 56.66 times the operating wavelength at an incidence angle of 61.68°. Moreover, the structure’s capability as a PSHE-based refractive index sensor is also evaluated. The analytical results demonstrate an average sensitivity of around 33,720 μm/RIU. The structure exhibits around five times higher PSHE-TD and approximately 150% improvement in sensitivity than the recently reported values in lossy mode resonance structures. Due to the purely dielectric material-assisted PhC resonator configurations and significantly higher PSHE-TD, the development of low-cost PSHE-based devices for commercial applications is envisaged.
Human Nature – An Embodied Phenomenological Perspective
Authors: Rahman Shiva
Published: May 2023

The paper attempts an analysis of the notion of “human nature” from a socio-historic perspective. Based on this analysis it shows how flawed is the concept of “reasonable man” that’s been upheld by the legal systems all over the world. In this effort, it points out how obsolete this conception is, and how unfair has this been to the existential reality of embodied human agency. After this, it ventures on to bringing to light a different scheme of such agency available in the existential phenomenological tradition that is capable of revolutionizing the notion of “reasonable man” and thereby enlightening criminal jurisprudence. And in view of such a re-orientation of the notion of human agency, the question that is addressed lastly in the paper is, what cause should the normative serve ultimately – retribution or reformation?
Opinions and Algorithms: Trust, Neutrality and Legitimacy
Authors: Razmetaeva Yulia
Published: May 2023

The article is devoted to opinions and algorithms in the digital age, with a focus on how the manipulation of the former while using the latter affects trust and legitimacy. In addition, some attention is paid to the issue of neutrality, both in relation to unbiased opinions and in relation to unbiased technologies. The article raises questions about whether we can be self-determining and self-governing agents, especially in terms of how we make decisions and what opinions we trust, if we are skillfully led to this by algorithms or those behind them.

Considering that not only corporations, but also governments today use technologies to influence our preferences and opinions, issues of autonomy and personal interests are touched upon, as well as the problem of nudging for certain behaviors that are defined as the best for people, including in a paternalistic sense. The article argues that the merging of everyday life with digital spaces and algorithmization form our experience as a fundamentally new one and does not contribute to the ability to separate imposed interests from really our own.

The questions of how power and legitimacy are redistributed in a digital society dependent on algorithms are discussed in this study. It has been suggested that the impact on our preferences and management of them, when someone try to sell us certain opinions, may be more dangerous than selling us goods and services, since it destroys institutional and interpersonal trust and contributes to the erosion of public institutions. The study shows how some technologies, primarily algorithmic ones, which are not neutral either in their essence or in the way they are used by their creators and owners, contribute to growing addiction and impoverish human interaction and the ability to form meanings.
Dicamba Degradation by Fenton-Like Process Using Iron/Biochar Composites
Authors: Guimarães Tiago , de Aguiar Adalin , da Silva Elisa , Mielke Kamila , da Costa Marcelo , da Silva Antonio , Teixeira Ana , Lopes Renata
Published: May 2023

In this work, an iron/biochar composite was evaluated as a catalyst for 3,6-dichloro2-methoxybenzoic acid (dicamba) herbicide degradation by heterogeneous Fenton-like process. The biochar was produced from pyrolysis of coffee husks. After FeII adsorption by biochar, the material was submitted to chemical reduction, via borohydride, producing zero-valent iron nanoparticles (BIO-Fe0 ). The material was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy and energy dispersive X-ray spectroscopy, Raman scattering spectroscopy, nitrogen adsorption/desorption analysis, among other techniques. The BIO-Fe0 is a heterogeneous material, and the main constituent elements are carbon (C), oxygen (O), silicon (Si), sulfur (S) and iron (Fe). The dicamba degradation was monitored by high-performance liquid chromatography and biological assays using beans (Phaseolus vulgaris) as indicator species. The commercial dicamba (500 mL; 250 mg L-1) was submitted to Fenton-like process (initial pH 3.20; BIO-Fe0 : 3 or 5 g; 1.00 mL H2O2 at 3.00 mmol L-1; 1.00 mL Al2(SO4)3 at 1.00 mol L-1; 25 °C and 5 h of reaction), presenting ca. 100% of degradation. These treated solutions were used in a biological assay. The intoxication levels were less 30%. These results show that BIO-Fe0 has the potential to be used in the dicamba degradation by Fenton-like processes.
Experimental study on continuous firing vibration response of the typical machine guns under different ground conditions
Authors: Liu Hengsha , He Long , Xu Cheng
Published: May 2023

In order to study the influence of ground conditions on the continuous firing vibration response of typical machine gun, and find out under which conditions the machine gun is most stable. A high-speed photography method was used to measure the motion of multiple parts. The motion curve of each part in the shooting process are obtained, and the projectile dispersion are recorded. According to the results, the motion characteristics of each part is analyzed. The pitching and translational quasi-periodic motions of the whole gun under different ground conditions are compared by synthesizing the motion data of various parts. The working modes of gun tripod under different ground conditions are discussed, and are compared according to the corresponding projectile dispersion. The result show that, in quasi-periodic pitching motion, the upward pitching motion response of the gun under the condition of cement ground is large, the ability to restore the initial position is poor, and the corresponding vertical dispersion is the worst. Under the soil condition, the upward and downward pitching motion cycle of the gun is relatively stable, the ability to restore the initial position is strong, and the corresponding vertical dispersion is the best. In terms of quasi-periodic translational motion, the translational motion of the gun mount under the cement ground is the biggest, and the corresponding horizontal dispersion is also the biggest. Under the soil ground condition, the translational motion is the smallest, and the corresponding horizontal dispersion is also the smallest.
Development of a genetic algorithm-based graph model for conflict resolution for optimizing resolutions in environmental conflicts
Authors: Pourvaziri Mitra , Mahmoudkelaye Samira , Yousefi Saied
Published: May 2023

Graph model for conflict resolution (GMCR) is a robust tool for resolving disagreements among parties with contradictory interests in a potential conflict. In GMCR, decision-makers (DMs) and their preferences are determined. The DMs are defined as people, parties, or groups having the authority to make decisions and the power to get these decisions approved. This definition excludes some potential stakeholders with no ability to make and exert decisions, like the natural environment. Therefore, this study aims to find an impartial viewpoint representing the natural environment's interests. A new GMCR based on genetic algorithm (GA) optimization is proposed to modify and optimize the final resolution of the GMCR regarding natural environment benefits. Having been applied to a real-world case study, this methodology showed competence in satisfying the fundamental interests of the natural environment to an acceptable extent. This case study is about an endangered seasonal lake, where there is contention between the governmental and agricultural sectors. The results revealed that the disagreement between two conflicting groups could be resolved by modifying the current agreement to consider both groups' demands. Finally, GA, incorporated in GMCR, proved to be a robust optimization technique in complex environmental conflicts.
ANFIS- and GEP-based model for prediction of scour depth around bridge pier in clear-water scouring and live-bed scouring conditions
Authors: Choudhary Amandeep , Das Bhabani Shankar , Devi Kamalini , Khuntia Jnana Ranjan
Published: May 2023

Scour depth prediction is an important aspect of designing a bridge pier structure in a river. Proper modeling of scour depth ensures the sustainability of the structure. An attempt is made to develop a scour depth model for the bridge pier using an adaptive network-based fuzzy inference system (ANFIS) and gene expression programming (GEP). The scour depth is found to be influenced by various independent parameters such as pier diameter, flow depth, approach mean velocity, critical velocity, Froude number, bed sediment, and geometric standard deviation of bed particle size. Gamma tests are performed to identify the best input parameter combinations to predict scour depth. In the present study, two separate models have been developed for clear-water scouring (CWS) and live-bed scouring (LBS). For different ranges of input parameters, the scour depth ratio is computed and error analysis is performed. Results indicate that the ANFIS model (R2CWS = 0.95, MAPECWS = 9.39% and R2LBS = 0.95, MAPELBS = 5.29%) is the most accurate predictive model in both scour conditions as compared to the GEP model and existing models of previous researchers. However, for the low value of pier diameter (b) to flow depth (y) ratio (<0.25), the present ANFIS model apportioned unsatisfactory results for LBS only.
Diversity of blaPOM in carbapenem-resistant opportunistic pathogenic Pseudomonas otitidis in municipal wastewater
Authors: Di Doris Yoong Wen , Cao Guangxiang , Zhong Chuanqing , Yan Tao
Published: May 2023

Metallo-β-lactamases (MBLs) encoding carbapenem resistance in wastewater are a well-known serious threat to human health. Twelve Pseudomonas otitidis isolates obtained from a municipal wastewater treatment plant (WWTP) in Hawaii were found to possess a subclass B3 MBL – POM (P. otitidis MBL), with a minimum inhibition concentration (MIC) range of 8–16 mg/L. The unrooted neighbor-joining phylogenetic tree showed that these blaPOM genes isolated in wastewater samples (n = 12) were distinctly different from other reference genes isolated from clinical, freshwater, animal, and soil samples except for isolates MR7, MR8, and MR11. MR7, MR8, and MR11 were found to have 4, 3, and 3 amino acid substitutions when compared to the type strain MC10330T and were closely clustered to the clinical reference genes. The meropenem hydrolysis experiment showed that isolates with multiple amino acid substitutions completely hydrolyzed 64 mg/L of meropenem in 7 h. The emergence of the opportunistic pathogen P. otitidis chromosomally encoding blaPOM in the treated municipal wastewater is an alarming call for the spread of this MBL in the environment. Further studies are required to understand the mechanism and regulation of this carbapenem-resistant β-lactamase in order to fill in the knowledge gap.
Agricultural irrigation water price apportionment and sharing
Authors: Huang Yulin , Wang Shuangyin , Li Xin , Cheng Dongling , Wang Zhe , He Bingjing , Fan Ronxin
Published: May 2023

Studying the apportionment and sharing of agricultural water prices is necessary for clarifying the relationship between agricultural water price apportionment and government responsibility and ensuring the benign operation of irrigated areas. From the perspective of the versatility of irrigation water, irrigation benefits are classified as internal or external; the degree of benefit is measured using the proportion of irrigation water per cubic metre of internal and external benefits. This is used as an allocation coefficient to reasonably share prices based on farmers’ water price tolerance, build agricultural water price apportionment and sharing models, and calculate the range of water prices borne by farmers and the government in the Baojixia Irrigation District in the Shaanxi Province of China. Results showed that the apportionment coefficients of farmers and government were 0.85 and 0.15, respectively. For grain crops, the farmers' price range was 0.115–0.508 yuan/m3, while that of the government was 0.516–0.909 yuan/m3; for cash crops, these values were 0.566–3.009 and 0.154–0.458 yuan/m3, respectively. The results of this study support the formulation of agricultural water prices and provide a theoretical reference for reducing the water burden of farmers and promoting the high-quality development of the regional economy
PERFIL DE SERVIÇOS PÚBLICOS QUE REALIZAM AVALIAÇÃO DO FRÊNULO LINGUAL EM NEONATOS NO RIO GRANDE DO NORTE
Authors: Samara Raquel Sousa de Oliveira  , Monique Ramos Paschoal Dutra
Published: May 2023

RESUMO

Introdução: A anquiloglossia é caracterizada pela alteração do frênulo lingual resultando na restrição dos movimentos da língua. A avaliação do frênulo lingual em neonatos é importante para diagnosticar precocemente essa alteração. Objetivo: Traçar perfil de serviços que realizam a avaliação do frênulo lingual em neonatos nos hospitais e maternidades públicas do estado do Rio Grande do Norte (RN).  Metodologia: Trata-se de um estudo observacional, descritivo e transversal, com abordagem quantitativa. Foram incluídos na pesquisa as maternidades públicas e filantrópicas do estado do RN que realizam procedimentos obstétricos e assistência materno-infantil. As informações acerca da avaliação do frênulo lingual em neonatos e caracterização desses serviços foram coletadas por meio de um questionário eletrônico. Os dados foram armazenados em planilhas no Excel e analisados através do Statiscal Package Social Sciences (SPSS) versão 23.0, onde foram conduzidas análises das variáveis investigadas. Resultados: Participaram do estudo 23 hospitais e maternidades públicas do RN, na qual constatou-se que apenas 7 (30,44%) ofertam a avaliação do frênulo lingual em neonatos no próprio estabelecimento, as demais encaminham para outros serviços. O exame foi implantado nas maternidades entre os anos de 2014 e 2018. A quantidade de profissionais que realizam esta avaliação variou entre 1 e 9 por instituição, e os profissionais envolvidos foram os fonoaudiólogos e cirurgiões-dentistas. A prevalência da anquiloglossia variou de 3,7% a 14,5%. A maioria das maternidades realizam a frenotomia e o profissional que executa é o médico ou cirurgião-dentista. Conclusões: Constatou-se uma baixa oferta da avaliação do frênulo lingual em neonatos no próprio estabelecimento de nascimento. Além disso, essa oferta ainda não acontece de forma universal, principalmente no interior do estado do RN.

Palavras-Chave: Anquiloglossia, Programas Nacionais de Saúde, Triagem Neonatal.
DESAFIOS DO ATENDIMENTO NUTRICIONAL EM TEMPOS DE PANDEMIA: RELATO DE EXPERIÊNCIA
Authors: Silva Ellen Cristina , Araújo Daline Fernandes de Souza , Felicio Aurivânia Kyrlle Peixôto , Lucena Luanna Kássia Sousa de , Freitas Fernanda da Fonseca
Published: May 2023

Introdução: Considerando o cenário de pandemia ocorrido nos últimos anos (2019- atual) em razão da grande propagação mundial do novo Coronavírus (SARS- CoV-2), tornaram-se necessárias medidas preventivas que corroborasse na diminuição do contágio e disseminação do vírus, dentre estas, o distanciamento social. Com isso, houveram muitas modificações e adaptações de protocolos assistenciais assim como no atendimento nutricional que, embasados em normativas do Conselho Federal de Nutricionistas por meio de resolução, permitiu a utilização do atendimento nutricional de maneira não presencial. Objetivo: Relatar  a experiência e desafios vivenciados durante o componente curricular Terapia Ambulatorial Nutricional- Prática II, do curso de Nutrição, por meio de atendimentos nutricionais híbridos, considerando o contexto de pandemia. Metodologia: Trata-se  de  um  relato  de experiência construído a partir das vivências do componente curricular  Terapia Ambulatorial Nutricional- Prática II (Módulo prático), que integra a grade do Curso de Nutrição, da Faculdade de Ciências da Saúde do Trairi- FACISA, da Universidade Federal do Rio Grande do Norte- UFRN, os atendimentos se passaram em um cenário de pandemia, demandando cuidados e alterações. Resultados: Percebeu-se a partir dessa vivência, que diante do cenário atual muitas adaptações precisaram ser realizadas, no entanto, a utilização de estratégias se fez bastante presente de modo que tornasse a proposta viável. Conclusões: São muitos os obstáculos enfrentados quanto ao atendimento nutricional no contexto de pandemia, haja vista que ajustes foram necessários no cronograma de consultas bem como limitações, os quais dificultaram muitas vezes a realização de uma abordagem igual à planejada. Porém, os obstáculos não tornaram inviável os atendimentos, de modo que foi possível atingir êxito nas consultas, metas e objetivos do paciente.
SISTEMA DE COTAS E DESEMPENHO ACADÊMICO: ESTUDO SECCIONAL EM UMA UNIVERSIDADE PÚBLICA BRASILEIRA
Authors: Costa Chene Ana Rafaela , Idelfonso Cardoso Maria Sidiane , Luz Miranda Mayara Sabrina , Costa Pinheiro Helder Henrique , Silva da Silveira Ana Daniela
Published: May 2023

Introdução: A lei de cotas (nº 12.711/2012) foi criada com o intuito de oportunizar o acesso de alunos oriundos de escolas públicas ao ensino superior. Desde então, medidas adicionais foram tomadas para garantir, não só o acesso, mas a permanência destes alunos nas universidades. Objetivo: Este estudo teve como objetivo avaliar o desempenho acadêmico de alunos cotistas (GC) e não cotistas (GN) da Faculdade de Odontologia da Universidade Federal do Pará. Metodologia: Foram coletados dados de alunos matriculados nos anos de 2020 e 2021 por meio de um questionário on-line e realizada a análise de histórico acadêmico dos voluntários. A análise dos dados foi realizada com software Jamovi versão 1.6.23, utilizando os teste Qui-quadrado, t de Student para amostras independentes e análise de regressão linear multivariada. Em todas as análises foi adotado o nível de significância de 0,05. Resultados: Com uma taxa de resposta de 39,92% (n=200), os resultados demonstraram haver um melhor desempenho acadêmico para o GN no que se refere ao CRG-Coeficiente de Rendimento Geral (p=0,001). Além disso, alunos do GC enfrentam mais dificuldades quando comparados aos do GN (p<0,0001). Na análise múltipla verificou-se que juntas, forma de ingresso (GC ou GN), o enfrentamento de dificuldades, recebimento de auxílios e atividades fora da Faculdade explicam quase 10% da variável CRG (R² = 0,098). Conclusões: A complexidade da comparação sugere a possibilidade de múltiplas causas, entre elas o fator socioeconômico e outras dificuldades experienciadas. Entender e atuar nestas causas é de fundamental importância para construção de uma universidade inclusiva de qualidade.
EDUCAÇÃO ALIMENTAR E NUTRICIONAL EM CASA: A EXPERIÊNCIA DO ENSINO REMOTO NA ESCOLA PÚBLICA EM MUNICÍPIO PARAIBANO
Authors: Ferreira Tavares Nonato Larissa , Evilys Dias da Silva Jhulia , Ramos de Araújo Raymme , Diniz Alves Maria das Graças , Bernardino Domingos José Douglas , Silva Freire de Souza Guilherme , De Araújo Palmeira Poliana , Macêdo Venâncio dos Santos Ana Beatriz
Published: May 2023

Introdução: Às medidas de segurança da COVID-19 direcionaram a adoção do modelo remoto de ensino, inclusive para ações de extensão universitária realizadas no ambiente escolar. A extensão contribui para a promoção da saúde ao abordar temas como a Educação Alimentar e Nutricional (EAN).  Objetivo: O objetivo deste trabalho é relatar a experiência da extensão universitária e a adaptação de ações de EAN ao modelo remoto, com escolares de ensino fundamental do interior da Paraíba em 2020. Metodologia: O projeto “#TICS: EAN em Casa foi realizado com escolares do ensino infantil ao 5º ano de uma escola pública de Cuité, Paraíba. Utilizou-se o whatsapp como ferramenta para as atividades baseadas no incentivo a brincadeiras com movimentação física, o desenvolvimento cognitivo, os vínculos intergeracionais e a alimentação de baixo custo. Foram desenvolvidas 12 ações, adaptadas à idade escolar e de fácil execução no domicílio, através de vídeos explicativos, plataforma de jogos e atividades impressas. Resultados: Observou-se os desafios: desigualdade no acesso à internet, fragilidade na manutenção do vínculo entre a equipe universitária com a comunidade escolar, sobrecarga dos professores e diversos contextos no ambiente familiar como, por exemplo, a vulnerabilidade social e violência doméstica. Conclusão: Contudo, é possível a realização da extensão universitária no modelo remoto a partir da diversificação de estratégias e ferramentas digitais, apesar dos desafios enfrentados para manter o vínculo entre equipe universitária-comunidade escolar.

Palavras-Chave: Educação Alimentar e Nutricional; Extensão Comunitária; Pandemia COVID-19; Tecnologia da Informação e Comunicação.
ANÁLISE DO PERFIL DE INTOXICAÇÃO EXÓGENA NO ESTADO DA BAHIA ENTRE 2012 A 2021
Authors: Souto Figueiredo Nepomuceno Ana Flávia , Souto Figueiredo Mariana , Oliveira dos Santos Liz
Published: May 2023

Introdução: As intoxicações exógenas têm sido um importante problema de saúde pública, em decorrência da sua elevada frequência, morbidade e complexidade. Objetivo: Analisar o perfil de intoxicação exógena no estado da Bahia durante o período de 2012 a 2021, utilizando como base de informações as notificações disponíveis no Sistema de Informação de Agravo e Notificação. Metodologia: Estudo transversal, descritivo, retrospectivo, de série temporal, com abordagem quantitativa, utilizando dados secundários de natureza pública disponibilizados pelo Ministério da Saúde do Brasil. Foram analisadas informações sobre as intoxicações exógenas no estado da Bahia no período temporal de 2010 a 2021. Avaliamos as variáveis total de notificações, total de notificações por ano, sexo, raça, faixa etária e escolaridade. A circunstância da intoxicação, o agente tóxico, os critérios de confirmação dos casos, tipo de exposição e a evolução dos casos também foram investigados. Resultados: No período temporal analisado, foram notificados um total de 46.187 casos de intoxicação exógena no estado da Bahia, com destaque para região leste do estado (43,26%). 55,21% dos indivíduos eram do sexo feminino, parda (46,52%), com faixa etária de 20 a 39 anos (41,71%), e com ensino médio completo (5,76%). A maioria dos casos aconteceram mediante a tentativas de suicídio (30,68%), tendo como principais agentes tóxicos o uso de medicamentos (36,39%). Grande parte dos casos foram confirmados mediante ao estado clínico (53,01%). As intoxicações aguda-única apareceram em maior proporção (53,05%). 1,15% dos pacientes notificados foram a óbito. Conclusões: As intoxicações exógenas consistem em um importante problema de saúde pública para o estado da Bahia, reiterando dessa forma, a importância da adoção de medidas preventivas.
OECD pension funds as an investment resource at the beginning of the third decade
Authors: Lebedeva L. F.
Published: May 2023

Pension strategies in OECD countries, the dynamics of pension fund assets at the beginning of the third century are highlighted in the article. Long term demographic pressure from ageing are accompanied at the end of the second – the beginning of the third decades by pandemic challenges with unstable contributions, slowing expectancy gains in old age, problems of low retirement benefits. After the first year coronavirus pandemic stress, the retirement savings in pension funds grew faster than GDP in the OECD area. Pension fund assets continue growing in almost all countries of the area, with the highest rate in Turkey, Lithuania; also a double-digit growth assets rate in Finland, France, Greece, New Zeeland, the United States, etc. As pension fund assets show large variations across countries, the decline of assets was mentioned in Chile, Peru, Estonia. The largest volume of assets are in the United States pension funds leaving far beyond the assets in each of the other countries; but taking the assets percent of GDP, in the Netherlands, Iceland, Denmark it’s higher than in the United States.
Multipolarity as the main characteristic of the post-global world: searching for new model economic outlines
Authors: Tarasov A. G. , Ishukov A. A.
Published: May 2023

In the context of rethinking globalization, the negative features of the world order model formed by this process and, as a result, the emerging characteristics of a new more harmonious model come to the fore. The purpose of the article is to outline the post-global world, but not as a model of the world order following after a certain time period behind the global world, but as a model of the world order with new qualitative characteristics that eliminate the shortcomings of the previous model. Such a characteristic as multipolarity is presented in more detail, in the formation of which took into account the reports of the V International Scientific and Practical Conference "Greater Eurasia: National and Civilizational Aspects of Development and Cooperation" (University of World Civilizations, Moscow, November 23–24, 2022). Since the literature is dominated by a political approach to multipolarity, the authors attempted to shed more light on the economic aspect of the problem. The hypothesis of polycentricity in integration associations is also developed.
On the parameters of economic development in the EAEU until 2035
Authors: Glazyev S. Y. , Tkachuk S. P.
Published: May 2023

The article analyzes the state of the economy of the EAEU countries and suggests measures to implement the opening opportunities in response to the "wave" of growth of a new technological way of life. The EAEU states need a powerful impetus to renew the basic potential in order to concentrate the available resources on priority areas of modernization and economic development. Its organization consists in increasing the savings rate from the current 18–20% of GDP to 35–40% of GDP, focusing investments on breakthrough areas of growth of a new technological way of life and modernization of the economy based on it. The source of financing for these investments may be a targeted credit issue organized by monetary authorities in accordance with centralized priorities.
First Approval of Elacestrant as a Selective Estrogen Receptor
Degrader for the Treatment of Metastatic Breast Cancer
Authors: De Surya K.
Published: May 2023

Elacestrant was approved by the US FDA on January 27, 2023, for treating
postmenopausal women or adult men with estrogen receptor (ER)-positive, HER2-
negative, ESR1-mutated advanced or metastatic breast cancer with disease progression
prior to using at least one line of endocrine therapy. In this short perspective, physicochemical
properties, dosage and administration, mechanism of action, pharmacodynamics,
pharmacokinetics, drug interaction, and treatment-related adverse reactions of elacestrant
are summarized.
Application of Network Pharmacology and Molecular Docking to Explore
the Mechanism of Danggui Liuhuang Tang against Hyperthyroidism
Authors: Song Dan , Yang Bin , Bao Wenzheng , Wang Jinglong
Published: May 2023

Introduction:

To investigate the mechanism of Danggui Liuhuang Tang (DGLHT) in the
treatment of hyperthyroidism (HT), we explored the multi-component, multi-target, and multi-pathway
mechanism based on the network pharmacology method of traditional Chinese medicine.

Objective:

Using network pharmacology and molecular docking, the effective components, core targets,
and critical pathways of DGLHT in the therapy of HT were investigated. The mechanism of DGLHT in
the treatment of HT is discussed in this work, which also offers a scientific foundation for further research
into the process.

Methods:

To take DGLHT into the blood components as the research object, we used GeneCards, Drungbank,
Therapeutic Target Database (TTD), Online Mendelian Inheritance in Man (OMIM), Pharmacogenetics
and Pharmacogenomics Knowledge Base (PharmGKB), and other databases to predict the potential
target of the components. Then, it was integrated with the predicted targets of HT disease to obtain the
potential targets of DGLHT in the treatment of HT. We used String database and Cytoscape software for
protein-protein interaction network (PPI) construction, and DAVID platform for Gene Ontology (GO)
analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation, the Cytoscape
software was used to construct a "component-target-pathway" network; the AutoDock Vina platform was
used to conduct molecular docking between the blood entry components and key targets.

Results:

According to the analysis, a total of 93 active ingredients, 348 disease-related targets, and 36 potential
targets were screened out. Among them, key targets such as MAPK1, CCND1, AKT1, and TNF
exert curative effects, and the main pathways are the HIF-1 signaling pathway, FoxO signaling pathway,
Chemokine signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, T cell receptor
signaling pathway, Jak-STAT signaling pathway, and other pathways. Molecular docking results
verified the interaction between active ingredients and key targets, among which rustication and quercetin
had high docking affinity with key target proteins MAPK1 and CCND1.

Conclusion:

This study preliminary revealed that DGLHT has the characteristics of multi-component,
multi-target, and multi-pathway in the treatment of HT, and it established a scientific foundation for a
more detailed investigation of DGLHT's molecular mechanism in the treatment of HT.
Effect of Nadi Sweda on symptoms of Pain, Swelling and Stiffness in Knee Osteoarthritis - An Open Labeled Single Arm Clinical Study
Authors: Baheti Sandipkumar , S Mahesh
Published: May 2023

Introduction: More than 100 million populations globally suffer from Osteoarthritis (OA) which is considered the leading cause of disability. The prevalence of OA knee in India is about 6% of total osteoarthritis. Therefore, there is a need for alternative and well-tolerable supplementary treatment which has no drug interaction with conventional drugs for OA. Aim and objectives: To evaluate the effect of traditional sudation therapy (Nadi Swedana) on pain, swelling and stiffness of patients with knee osteoarthritis. Method: The study was conducted after getting approval from Institutional Ethical Committee and was registered to the Clinical Trials Registry of India (CTRI/2018/03/012636 19/03/2018). A total of 20 patients with knee joint osteoarthritis were treated for 6 weeks. Pre-test and the post-test outcome measure was recorded on subjective parameters and statistically analyzed. Results: The applied score for pain, swelling and stiffness decreased significantly lower after the intervention (p<0.05). Conclusions: Traditional sudation therapy by Nadi Swedana was beneficial for patients with knee osteoarthritis.
Study the efficacy of Murvadya Choorna Vati in Pandu Vyadhi with special reference to Iron Deficiency Anaemia
Authors: Yogesh T. Kotangale  , S.V. Bhosle
Published: May 2023

Rasa and Rakta Dhatus play very important role in our human life. Rasa and Rakta are considered as key factor for the nourishment and life maintenance of the body. In today’s world of urbanization and modern lifestyle, many times it is seen that higher economic class and lower economic class are all malnourished under different circumstances. These factors include fast food, low nutritional value food, stressful & hectic life, which in turn contribute to create very common and well-known disease Pandu. On the basis of similarity of aetiological factors and symptoms Pandu Vyadhi can be correlated with Anaemia. Anaemia is a decrease in the total amount of red blood cells or haemoglobin in the blood or a lowered ability of the blood to carry oxygen. It is caused due to number of causes including nutritional deficiencies, acute or slow blood loss due to trauma or disease, destruction of red blood cells due to various metabolic and immunological abnormalities or toxins, diseases of the bone marrow, general systemic diseases like infection and various varieties of cancer, kidney failure etc. In the present study, Murvadya Choorna Vati is described by Gada Nighraha in Pandu Vyadhi. Murvadya Choorna Vati contains Murva, Bala and Chitrak. Hence it is used in Pandu Vyadhi due to its Deepana, Pachana and Rasayana property.
Rogamarga - A clinical and therapeutic indicator: A Critical Review
Authors: Meenakshi Sharma  , Manish Kumar  , Pooja Arya  , Deepti Mehta  , Sisir Kumar Mandal
Published: May 2023

Rogamarga is the unique speciality of Ayurveda which means the pathway of diseases. The Rogmarga act as passage for movement of Doshas and site of amalgamation for morbid Doshas and Dushyas (body tissue). It is essential to understand pathological process involved in manifestation of disease. The normal relationship between Rogmarga, Doshagati and dhatu formation is responsible for health status of individual and any disturbance in the same is responsible for morbidity. Hence, the concept of Rogmarga is vital to understand patho-physiology of body systems. It has diagnostic, prognostic and therapeutic utility both in acute and chronic disease.
Role of Trividh Rogayatana in the manifestation of Life Style Disorders with special reference to Charak Samhita - A Review
Authors: Swati Vyas
Published: May 2023

Ayurveda is the ancient medical science of the world. It is first focuses on maintain health of human beings. Maintaining of health by proper using of Ahara (diet), Vihara (daily routine). Ahara or Anna maintain health by proper metabolism. Ayurveda also has classified the causes of disease into three main categories- 1. Asatmendriyartha Samyoga 2. Pragyaparada and 3. Parinama (Kaala), these three main causes of disease enable different kinds of diseases to manifest. Firstly, they lead to the imbalance of body / or mind by vitiation the Tridosha. The consequence of the imbalance is a disturbance of the basic biological principles. In Ayurveda causes of life style disorders are mainly Pragyaparada. Pragyaparadha are main causes of all noncommunicable diseases (NCDs) such as diabetes, cancer, hypertension etc.
A conceptual study on Liver Abscess with reference to Abhyantara Vidradi
Authors: Roja SR  , Shailaja SV
Published: May 2023

Vidradhi is a Rakta Dusti Vikara which undergoes rapid suppuration followed by Puya formation. Acharya Sushrutha has explained ten Adhishthanas of Antarvidradhi, among these Yakrit Vidradhi is also mentioned. Acharya Charaka has explained Vidradhi under Raktavaha Sroto Vikara in which Rakta Dushti and Paaka takes place predominantly. In modern concepts, one can precisely correlate abscess with Vidradhi. The extremely deranged and aggravated Vata, Pitta, Kapha resorting to the bone and vitiating Tvaka (skin) Rakta (blood), Mamsa (flesh) and Meda (fat) of person (with their own specific properties) gradually give rise to deep seated, painful, round or extended Shopha (swelling) is called Vidradhi.[1] It is of 6 types: Vataj, Pittaj, Kaphaj, Sannipataj, Kshataj And Raktaj. According to the site it is of two types- Bahya (external) and Antah (internal) Vidradhi.[2]
Role of Simhasana in the management of Hypothyroidism: A Review
Authors: Neha P. Pawar  , Vrushali Khandekar  , Sumeeta Jain
Published: May 2023

Hypothyroidism is a condition in which thyroid does not create and release enough thyroid hormone into blood Stream. People with thyroid disorder often hove emotional or mental health symptoms as well as physical symptom. Yoga is a series practises i.e., physical, mental, and spiritual practices which are originated from ancient India. Application of Yoga posture and practice to the treatment of hypothyroidism is the main aim of this article. In Yoga Bandhas are the most powerful technique as they change internal chemistry of the body in a fundamental way. Out of 4 types of Bandhas, Jalandhar Bandha (throat lock) is most important in treating throat disorder. In Simhasana there is application of Jalandhar Bandha, due to application of Jalandhar Bandha blood flow through carotid arteries get reduces which send signal to the brain activates parasympathetic nervous system as a result it create calmness in mind and relieve stress, anxiety, depression, and chronic pain, improve sleep patterns, and enhance overall well-being and quality of in thyroid disorder. Simhasana presses the thyroid gland thereby increasing vascularity of the gland and maintaining proper functioning of gland, hence by practising this Asanas over a few months will definitely helps in hypothyroidism.
Sthanika Chikitsa in the geriatric women suffering from Dyspareunia – A Case Study
Authors: Shravani P.  , Savita S. Patil
Published: May 2023

The etiological factor of Yoni Vyapat are mainly due to the vitiation of Doshas, among which Paripluta Yoni Vyapat is due to the vitiation of Vata Dosha, which can be correlated to Dyspareunia. Dyspareunia means the coital act is difficult and or painful. There is different etiology depending upon the site of pain, out of which Vagina Atrophy prevalence of 67.5% associated with vaginal dryness – 62%, itching 40%. For the better and fruitful result Sthanika Chikitsa (local therapies) has been enumerated as an important part of Yoni Vyapad Chikitsa, which includes Yoni Parisheka (cleansing of vagina), Yoni Abhyanga (massaging of vagina with medicated oil), Yoni Pralepa (semisolid drug applied on the vaginal wall), Yoni Pichudharana (medicated soaked tampon place in vagina). Case Study: A female aged 49 years, approached OPD complaining of painful coitus along with dryness and itching of vagina, which increased after her menopause. The condition was treated with Sthanika Chikitsa followed by internal medications.
The role of modified Pichha Basti in the management of Ulcerative Colitis - A Case Study
Authors: Sonika Solanki  , Preeti Chaturvedi  , Mamta Dhurve
Published: May 2023

Ulcerative colitis (UC) is an inflammatory bowel disease that causes inflammation and ulcer in digestive tract. UC affected the innermost lining of large intestine also called the colon and rectum. In most popular symptoms usually develop over time rather than suddenly. UC can be draining or sometimes lead to life threatening complication. While it has no know cure there are several new treatments that can greatly reduce sign and symptoms of the disease and bring about long term remission. In Ayurveda Raktaatisara, Pitajatisara, Parvahika and Grahani shows symptoms having resemble with UC like blood and bile mixed stool with excessive foul smell, burning sensation, suppuration of colon and anus, colic pain etc. Pichha Basti indicated in Parvahika, Grahani and Atisara by Acharya Charaka and Vagbatta. This Basti reduce inflammation due to its Grahi, Deepandravya and Picchila Guna. It also improves the function of Apanvata. In modern medical science many conventional medicines are used in ulcerative colitis some drug like mesalamine may give relief in sign and symptoms but this drug is not suitable due to their side effects. The patient gradually developed the following symptoms like bilateral joint pain in all major and minor joints, hair loss, reddish discoloration on bilateral medial aspect of thigh and hip etc.
Management of Unexplained Female Infertility through Ayurvedic treatment - A Case Study
Authors: P. Deepika Bhat  , Mamatha K.V.
Published: May 2023

Infertility is an emerging health issue in present scenario. The term ‘Unexplained infertility’ may be applied to a couple who has failed to establish pregnancy despite an evaluation uncovering no obvious reason for Infertility or correction of the factors identified as probably responsible for infertility. It is commonly accepted that approximately 15% of couples will be determined to have Unexplained infertility. Ayurveda explains female infertility as Vandhyatwa and Primary factors associated with Vandhyatwa are abnormalities in Garbha Sambhava Samagri. In this case study patient aged 29 years who was anxious to conceive since 10 years of married life seeking Ayurvedic treatment in SDM College of Ayurveda, Udupi was taken. Routine investigations of partners showed Normal Study. The line of treatment followed in this case was Vatanulomana, Shodhana, Rasayana, Vrishya, Garbhasthapana with psychological assurance which is most important for conception and the patient conceived.
Ayurveda is a single hope for Autoimmune disease Psoriasis : A Case Study
Authors: Prachee Rahangdale  , Rajesh Meshram  , Shraddha Sharma
Published: May 2023

An autoimmune disease are arises due to abnormal response of immune system. Psoriasis is one of very common autoimmune disease characterized by dry skin and raised, rough, red areas on the skin covered with fine silvery scales and itching in the lesion of skin they disturb the daily routine of the patients. In Ayurveda all the skin diseases are described under a broad term of Kustha, which are further divided in Mahakustha & Kshudra Kustha. Kitibha Kustha one among 11 varieties of Kshudra Kustha which resembles psoriasis clinically. In modern medicine There is no certain cure for this disease, it provides symptomatic relief but also has side effects in long course. Here an effort was made to treat a 29year old female diagnosed case of plaque psoriasis, by Ayurvedic regimen. In the study initially Virechan Karma was performed. After Sanshodhan, Sanshamana drugs were given for 30 days. After 30 days we observed a marked improvement in overall condition of the patient with no recurrence since last 4 months.
Preferred methods of Diagnosis and Treatment of Benign Prostatic Hyperplasia adopted by Ayurveda practitioners - A Survey Study
Authors: Dahiya Abhijeet , Dharmarajan Prasanth
Published: May 2023

Introduction: Benign Prostatic Hyperplasia (BPH) refers to the nonmalignant growth of prostate gland. In Ayurveda, it can be correlated with Mutraaghata or Mutradosha. Currently used common oral medications such as 5α-reductase inhibitors, α1-Blockers as well as surgical treatment methods such as Transurethral Resection of the Prostate (TURP) have well-known side effects. Ayurveda case studies on BPH show evidence of a potential alternative to these current methods. Objectives: To conduct a survey to know the diagnostic methods and treatment modalities used by different Ayurveda Practitioners in BPH treatment. Materials & Methods: A survey comprising 7 questions in the form of multiple-choice questions on the diagnosis and treatment methods of BPH adopted by Ayurveda Physicians was done. The answers were recorded and interpreted in the form of graphs and pie charts. Results: A total of 57 different Ayurveda practitioners participated in the survey. Prevalence of BPH was seen more in the age group of 60-70 years. Ultrasonography (USG) and Prostate Specific Antigen (PSA) were among the most commonly used diagnostic methods for BPH. Most common symptoms observed were increased frequency of urine, urine incontinence and urine urgency. Uttara Basti (administration of medicine through the urethra) was the most recommended type of treatment procedure preferred, followed by Matra Basti (enema). Avagaha Swedana (Sitz bath) was recommended by most practitioners. The course duration of treatment is advised to be around half to one month. Around 40-60% relief was claimed in patients with BPH by the participants. Conclusion: BPH is a condition that is currently being treated by various Ayurveda practitioners using classical treatment methods such as Uttara Basti, Matra Basti etc. with claimed relief of about 40-60% by the participants.
An observational study of anatomical changes in Lumbar Spine produced due to Atibharvahan in farmers using MRI
Authors: Dibyajyoti Moharana  , Sarbeswar Kar  , K. C. Das
Published: May 2023

For diagnosis and treatment of various diseases anatomical study i.e., Rachana Sharir is necessary. Rachana Sharir - human anatomy is explained in detailed by various Acharyas in their Samhitas. For locomotory movements of human body, bones and joints are essential aspect of anatomical learning. Detail explanation of Asthi (bones) is described in Ayurvedic classics and modern science which will be studied and utilized for the observational study of lumbar spine in farmers due to Atibharvahan. India is agriculture predominant country. As numbers of farmers are more which deals with heavy weight lifting leading to physical stress and strain in Lumbar spine, which was not studied earlier.
A comparative clinical study of Erandbeejadi Gutika and Pippalyadi Gana Kashaya with external application of modified Ruksha Pottali Sweda in the management of Amavata
Authors: Byomesh Upadhyay  , Aruna Ojha  , Rashmi Diwan  , Jeevan Lal Sahu
Published: May 2023

Background: Amavata is a very challenging and burning problem in society. The clinical presentation of Amavata is closely related to the special variety of musculoskeletal disorder rheumatoid arthritis (RA). There is no medical system that is successful in providing a complete cure for the disease, so the Ayurvedic approach toward the treatment of Amavata is needed in the present era. The prevalence of RA is approximately 1% of the total population. For the management of RA in allopathic science, DMARDs & steroids are used frequently. Due to the lack of effective drugs and major problem in society, this disease for the study has been selected. Aim and Objectives: To study the efficacy of Erandbeejadi Gutika and Pippalyadi Gana Kashaya with modified Ruksha Sweda in the management of Amavata (RA). Methodology: It will be a single-center, randomized, open-clinical study. In this study, 60 clinically diagnosed patients of Amavata were selected and randomly divided into two groups by coin method. Erandbeejadi Gutika will be given in the dose of two tablets (each 500 mg) four times in a day with lukewarm water before meal for 90 days along with the modified Ruksha Pottali Sweda, while Pippalyadi Gana Kashaya will be given 50 ml two times in a day before the meal along with the modified Ruksha Pottali Sweda. Statistical analysis will be done using the Wilcoxon matched-pairs signed ranks test for the analysis of nonparametric data, while paired t-test will be used for parametric data analysis, and mann-whitney test and unpaired t-test will be used for intergroup comparison.
Ayurvedic management of Paripluta Yonivayapad - A Review
Authors: Choudhary Malika , Sharma Rashmi
Published: May 2023

Yonivyapad comprises around 70% of gynaecological problems and commonly encountered in the practice of Gynaecology. Among them some are causing painful coitus, dysmenorrhoea etc., and Paripluta is one among them. Paripluta is one among the twenty Yoni Vyapads mentioned in the classics. In this disease Pitta and Vata Dusti are considered as primary cause. It can be correlated to pelvic inflammatory disease due its resemblance of clinical features. PID is of public health issue, especially in developing countries because of its high prevalence, economic and social implication. Delayed management of PID may result in higher rates of miscarriage, chronic pelvic pain, STD, progressive organ damage and long term reproductive disability due to its recurrence.