bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECTS OF PHYSICAL EXERCISE ON THE INSULIN-DEPENDENT DIABETES MELLITUS SUBJECTS USING THE MODIFIED MINIMAL MODEL
Authors: Kartono Agus , Irawati Febri Dwi , Setiawan Ardian Arif , Syafutra Heriyanto , Sumaryada Tony
Published: February 2017

Objective: In this paper, the modiﬁed minimal model (MM) with a mathematical function for describing the insulin infusion rates was used to study of the effects of physical exercise on the dynamics of glucose and insulin on the insulin dependent diabetes mellitus (IDDM), including type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) subjects.

Methods: In an intravenous glucose tolerance test (IVGTT) procedure, a dose of glucose was administered intravenously to overnight-fasted subjects, 20 min after the glucose bolus, insulin was injected over 1-2 min either into the portal vein or into the femoral vein, and subsequently the glucose and insulin concentrations in plasma were frequently sampled (usually 30 times) over a period of 180 min. The dynamic glucose and insulin responses to glucose and insulin injection were analysed using the modified MM without and with physical exercise from IVGTT data.

Results: Our simulation results shown physical exercise improved blood glucose control and enhanced insulin sensitivity (SI) index in subjects with T1DM and T2DM. However, the T1DM and T2DM subjects need to be aware of the basic strategies to prevent hypoglycemia and maintain reasonable glucose control. It should be noted that the putative improvement in exercise-induced peripheral SI index in subjects with T1DM and T2DM was not always coincidental with the improvement of the insulin dosage.

Conclusion: The feature increased physical exercise, along with knowledge about how to modify daily insulin dosage to prevent hypoglycemia, improved blood glucose control and enhanced SI index. 
Do Social Ties between External Auditors and Audit Committee Members Affect Audit Quality?
Authors: He Xianjie , Pittman Jeffrey A. , Rui Oliver M. , Wu Donghui
Published: February 2017

We examine whether social ties between engagement auditors and audit committee members shape audit outcomes. Although these social ties can facilitate information transfer and help auditors alleviate management pressure to waive correction of detected misstatements, close interpersonal relations can undermine auditors' monitoring of the financial reporting process. We measure social ties by alma mater connections, professor-student bonding, and employment affiliation, and audit quality by the propensity to render modified audit opinions, financial reporting irregularities, and firm valuation. Our evidence implies that social ties between engagement auditors and audit committee members impair audit quality. In additional results consistent with expectations, we generally find that this relation is concentrated where social ties are more salient, or firm governance is relatively poor and agency conflicts are more severe. Implying reciprocity stemming from social networks, we also report some suggestive evidence that audit fees are higher in the presence of social ties between an engagement auditor and the audit committee. Collectively, our analysis lends support to the narrative that the negative implications—namely, worse audit quality and higher audit fees—of these social ties may outweigh the benefits.
Pentingnya Modul Kesehatan Reproduksi Remaja Berbasis Masalah (KRRBM) untuk Melatih dan Meningkatkan Keterampilan Hidup (Life Skills) dan Sikap Reproduksi Sehat Siswa SMP
Authors: Made Citrawathi Desak
Published: February 2017

Tujuan utama penelitian ini adalah untuk mengetahui pentingnya mengembangkan Modul Kesehatan Reproduksi Remaja Berbasis Masalah (KRRBM) untuk melatih dan meningkatkan keterampilan hidup (life skills) dalam bidang kesehatan reproduksi dan meningkatkan sikap reproduksi sehat siswa SMP. Untuk mencapai target tersebut dilakukan penelitian pengembangan yang mengacu pada model Dick dan Carey. Prosedur penelitian meliputi lima tahap, yaitu: (1) penetapan mata pelajaran, (2) analisis kebutuhan, (3) pengembangan modul KRRBM, (4) penyusunan modul, dan (5) review dan uji coba modul KRRBM. Penelitian tahap pertama ini dilakukan analisis kebutuhan dan penyusunan prototipe modul KRRBM. Penelitian dilakukan di SMP Negeri dan Swasta di Kota Singaraja-Bali. Sekolah yang dilibatkan sebagai sampel ditentukan dengan teknik purposive random sampling. Metode pengumpulan data dilakukan dengan wawancara, angket, dan FGD, dengan melibatkan kepala sekolah, guru, dan siswa. Data yang diperoleh dianalisis secara deskriptif. Hasil yang diperoleh bahwa sebagian materi KRR sudah diberikan pada mata pelajaran IPA. Informasi KRR juga diberikan pada kegiatan ekstrakurikuler Kelompok Siswa Peduli AIDS dan Narkoba, serta melalui ceramah dan poster. Strategi pembelajaran yang digunakan belum melatih keterampilan hidup  terkait KRR dan belum membelajarkan sikap reproduksi sehat. Kendala yang dihadapi sekolah dalam PKRR adalah menentukan strategi pembelajaran yang sesuai untuk melatih keterampilan hidup dan pembelajaran sikap, buku sumber, waktu, dan biaya. Sekolah sangat setuju dikembangkan dan disusunnya modul KRRBM untuk membelajarkan siswa tentang KRR.
PENGARUH SERTIFIKASI DOSEN TERHADAP KINERJA PENGAJARAN DOSEN UNDIKSHA
Authors: Sonia Piscayanti Kadek
Published: February 2017

Sertifikasi dosen adalah suatu sistem penghargaan berupa sertifikat pendidik kepada dosen yang didapatkan melalui serangkaian penilaian. Sertifikasi dosen adalah upaya pemerintah untuk meningkatkan profesionalisme dosen di bidang tri dharma perguruan tinggi. Bagi dosen yang telah lulus sertifikasi, diberikan tunjangan sertifikasi yang diharapkan meningkatkan kinerjanya di bidang pendidikan dan pengajaran, penelitian dan pengabdian pada masyarakat. Penelitian ini bertujuan untuk mengetahui pengaruh sertifikasi dosen terhadap kinerja pengajaran dosen Universitas Pendidikan Ganesha. Subjek penelitian ini adalah dosen Undiksha berjumlah 35 orang yang diambil dengan teknik simple random sampling dari 7 fakultas yang ada di Undiksha. Mereka merupakan para dosen yang telah tersertifikasi pada tahun 2012 dan memiliki jabatan fungsional maksimal Lektor. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan metode penelitian survey dimana pengambilan datanya menggunakan kuesioner. Analisis uji beda yang digunakan adalah uji statistik non parametrik dengan Wilcoxon Match Pairs test dan hasilnya menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara kinerja pengajar dosen Undiksha sebelum dan setelah sertifikasi dosen.
IBM UNTUK GURU IPA SD DI KECAMATAN BANJAR, KABUPATEN BULELENG-BALI
Authors: Agustiana I G.A. Tri
Published: February 2017

Mata pelajaran IPA bertujuan membekali peserta didik memiliki kemampuan mengembangkan pengetahuan dan pemahaman konsep-konsep IPA yang bermanfaat dan dapat diterapkan dalam kehidupan sehari-hari, mengembangkan rasa ingin tahu, sikap positif, dan kesadaran tentang adanya hubungan yang saling mempengaruhi antara  IPA, lingkungan, teknologi dan masyarakat, mengembangkan keterampilan proses untuk menyelidiki alam sekitar, memecahkan masalah dan membuat putusan. Oleh karena itu guru diharapkan mampu menggunakan media atau sumber belajar yang sebaik mungkin untuk menanamkan konsep yang baik dan benar kepada siswa. Namun selama ini guru IPA SD di Kecamatan Banjar, Buleleng Bali belum banyak yang memanfaatkan lingkungan sebagai sumber belajar. Proses pembelajaran menggunakan metode ceramah, sehingga prestasi belajar dan aktivitas siswa relatif rendah. Inspirasi kegiatan ini adalah, (1) peningkatan keterampilan guru-guru IPA SD di kecamatan Banjar untuk membuat dan menggunakan KIT IPA, (2) peningkatan keterampilan guru IPA SD dalam menyusun rencana pelaksanaan pembelajaran (RPP) sesuai dengan Permendiknas 41 Tahun 2007, (3) Peningkatan penggunaan assesmen dan penelitian tindakan kelas (PTK) dalam mendiagnosa kesulitan belajar siswa.Metode yang digunakan adalah aplikasi ipteks khusus teknologi pendidikan dan pembelajaran, lewat workshop. Keberhasilan metode yang diterapkan diukur dengan menggunakan   pendekatan   proses   dan   produk   melalui   metode   observasi   dan wawancara setelah kegiatan berlangsung.Karya utama kegiatan ini adalah (1) KIT IPA berbahan baku lingkungan, (2) RPP pembelajaran inovatif, (3) assesment dan, (4) laporan penelitian tindakan kelas (PTK) dan artikel ilmiah bagi guru IPA SD. Ulasan karya utama adalah KIT IPA adalah media untuk belajar,yang dibuat untuk meningkatkan dan mempermudah pemahaman konsep IPA, KIT IPA yang dibuat dari bahan-bahan yang mudah didapatkan di sekitar Sekolah Dasar. RPP yang dibuat oleh para guru IPA SD se kecamatan Banjar sesuai dengan Permendiknas No.41/2007. Penelitian tindakan kelas dilakukan dengan menerapkan KIT IPA, yang didahului dengan penyusunan proposal PTK. Hasil penelitian tindakan kelas dari mitra, yang berperan sebagai guru model untuk kecamatan Banjar ternyata dapat meningkatkan prestasi belajar IPA siswa SD.Dampak dari kegiatan ini adalah para guru IPA SD di Kecamatan Banjar mulai kreatif membuat KIT IPA yang bersumber dari bahan-bahan yang ada di lingkungannya dan antusias untuk melakukan penelitian tindakan kelas bagi guru- guru IPA. Hasil penelitiannya, kemudian digunakan sebagai materi ajar, kemudian untuk dijadikan buku ajar. Ada beberapa guru telah menerima pesanan KIT IPA agar bisa diterapkan di sekolah yang berbeda. Kondisi kondusif ini harus tetap dipelihara untuk meningkatkan nilai tambah keterampilan guru dan sisi ekonomi guru sebagai sumber penghasilan baru
IbM KELOMPOK USAHA TERNAK BABI DI DESA BANYUNING
Authors: Zukri Anjuman
Published: February 2017

Permasalahan yang dihadapi kelompok ternak babi di desa Banyuning adalah rendahnya pengetahuan dan keterampilan peternak dalam pengolahan limbah babi menjadi produk yang bernilai ekonomis. Upaya pemecahan masalah yang diprogram dalam IbM (Ipteks bagi Masyarakat) adalah pemberdayaan kelompok ternak babi dalam penerapan teknologi tepat guna pengolahan sampah menjadi energi alternatif bio-gas, dan pupuk organik. Metode pelaksanaan IbM menggunakan metode PALS (participatory action learning system). Hasil yang diperoleh dari program IbM adalah (1) adanya peningkatan pengetahuan dan keterampilan dalam pengolahan sampah menjadi bio-gas dan   pupuk kompos, (2) kualitas dan kuantitas pupuk kompos dan biogas kelompok ternak babi di desa Banyuning relatif cukup baik.
PENDAMPINGAN PELAKSANAAN PENELITIAN PENGEMBANGAN BAGI GURU SD GURU DI KOTA SINGARAJA
Authors: Tegeh I Made
Published: February 2017

Berdasarkan identifikasi masalah, maka secara umum masalah yang dapat dirumuskan adalah sebagai berikut. Bagaimanakah meningkatkan pengetahuan dan keterampilan guru dalam melaksanakaan penelitian melalui Pendampingan Pelaksanaan Penelitian Pengembangan bagi Guru-guru SD di Kota Singaraja? Tujuan kegiatan P2M ini adalah untuk   meningkatkan   pengetahuan   dan   keterampilan   guru   dalam   melaksanakan penelitian  pengembangan  melalui   Pendampingan  Pelaksanaan  Penelitian Pengembangan bagi Guru-guru SD di Kota Singaraja. Khalayak sasaran yang akan dilibatkan dalam kegiatan P2M ini adalah para guru SD di Kota Singaraja sebanyak lima orang.. Kegiatan ini berupa pemdampingan pelaksaaan penelitian pengembangan dengan menekankan pada keterampilan melaksanakan penelitian pengembangan. Kegiatan P2M ini telah mampu meningkatkan pengetahuan dan keterampilan para guru untuk melaksanakan penelitian pengembangan. Hal ini dapat dilihat dari hasil penilaian produk buku ajar yang dihasilkan oleh para guru. Nilai rerata buku ajar yang dihasilkan oleh para guru adalah 85,00 berada pada kategori sangat baik. Terdapat beberapa saran yang diajukan terkait dengan pelaksanaan P2M ini adalah sebagai berikut. (1) Para guru SD yang telah didampingi melaksanakan penelitian pengembangan hendaknya mencoba melaksanakan penelitian pengembangan untuk mata pelajaran lain dengan produk yang berbeda, seperti Lembar Kerja Siswa, mdul, media, dan lain-lain. (2) Hasil yang diperoleh oleh para guru perlu diimbaskan kepada para guru yang lainnya agar kegiatan ini dapat memberikan manfaat yang luas bagi masyarakat, khususnya para guru yang berminat melakukan penelitian pengembangan.
PEMANFAATAN BARANG BEKAS LAYAK PAKAI SEBAGAI ALAT PERAGA BAHASA DI TK WISATA KUMARA DAN TK KUMARA KERTI
Authors: Adnyani Ni Luh Putu Sri , Paramarta I Made Suta , Suarcaya Putu
Published: February 2017

Kegiatan  pengabdian  pada  masyarakat  yang  berjudul “Pemanfaatan  Barang  Bekas Layak Pakai sebagai Alat Peraga Bahasa di TK Wisata Kumara dan TK Kumara Kerti” merupakan sebuah kegiatan pelatihan yang diberikan kepada guru-guru TK yang bertujuan untuk Adapun tujuan darai pelaksanaan kegiatan  P2M ini adalah: 1)Untuk meningkatkan kuantitas dan kualitas alat peraga bahasa kelompok Taman Kanak-Kanak Wisata Kumara dana Kumara Kerti, 2) untuk meningkatkan variasi atau keberagaman alat peraga bahasa yang dimiliki TK-TK tersebut, dan 3) untuk membantu guru dalam upaya pencapaian standar perkembangan bahasa anak melalui alat peraga bahasa yang memadai.  Kegiatan  telah  dilaksanakan  pada  bulan  September 2013.  Pada  kegiatan tersebut alat peraga yang dihasilkan adalah buku berbincang dan kartu memori.
PELATIHAN DAN PENDAMPINGAN REMAJA TEMAN SEBAYA PEDULI KESEHATAN REPRODUKSI DI DESA SINABUN KECAMATAN SAWAN
Authors: Putra Adnyana , Kurnia Widiastuti Giri Made , Dewi Sri Wahyuni Ni Putu , Pasek Suadnyani Made
Published: February 2017

Fase remaja merupakan fase yang sangat rentan dan perlu dijaga dengan baik. Pada fase ini salah satu hal yang penting adalah menjaga kesehatan reproduksi. Tingkat pernikahan usia muda di desa Sinabun cukup tinggi. Fakta lainnya adalah ditemukannya kasus Hal ini bertautan dengan berbagai macam faktor seperti pengetahuan mengenai kesehatan reproduksi yang kurang, tingkat pendidikan yang rendah, sosial ekonomi yang rendah, dan kurangnya fasilitas yang menunjang aktivitas remaja secara positif di luar sekolah. Masalah yang diintervensi pada program ini adalah kurangnya pengetahuan remaja mengenai kesehatan reproduksi. Metode yang dipakai adalah pelatihan serta pendampingan remaja teman sebaya yang peduli kesehatan reproduksi. Beberapa media yang diberikan antara lain booklet dan CD berisi materi kesehatan reproduksi. Karya utama program ini adalah pelatihan dan pendampingan. Kekurangan yang dihadapi dalam program ini adalah beberapa peserta kurang aktif terutama dari remaja berusia lebih muda. Pelatihan dan pendampingan yang diberikan terbukti meningkatkan pengetahuan remaja mengenai kesehatan reproduksi serta kemampuannya dalam konseling mengenai kesehatan reproduksi bagi teman sebayanya. Kegiatan ini memberikan dampak yaitu meningkatnya wawasan dan pemahaman remaja mengenai kesehatan reprdduksi sehingga mereka dapat menjaga kesehatan reproduksinya dengan lebih baik. Kesehatan reproduksi yang dijaga dengan baik ini secaa tidak langsung meningkatkan taraf ekonomi dan sosialnya karena dengan kesehatan reproduksi yang baik memungkinkan individu dapat lebih merencanakan masa depannya menjadi lebih baik.
PELATIHAN KESELAMATAN DAN KESEHATAN KERJA (K3) PERTANIAN DI DESA ANTAPAN, KECAMATAN BATURITI, KABUPATEN TABANAN
Authors: Kurnia Kurnia Widiastuti
Published: February 2017

Petani merupakan kelompok kerja terbesar di Indonesia. Pertanian dan perkebunan dapat dianggap sebagai satu masyarakat tertutup, sehingga usaha-usaha kesehatan pun harus disesuaikan dengan sifat-sifat masyarakat demikian, dalam arti menyelenggarakan sendiri dan untuk kebutuhan sendiri. Perilaku K3 yang tepat dalam penggunaan pestisida sangat penting sebagai upaya pencegahan keracunan, sehingga perilaku K3 petani pengguna pestisida perlu disosialisasikan secara terintegrasi. Melalui wawancara awal tentang K3 dengan petugas kesehatan yang berprofesi sebagai bidan desa, diperoleh beberapa fakta yang menggambarkan kebutuhan akan penyelenggaraan  pelatihan K3 dimana 1) adanya faktor penyebab lainnya yang juga mempengaruhi tertundanya usaha promotif Puskesmas yaitu masih rendahnya pengetahuan tentang prinsip K3 pertanian yang dimiliki oleh petugas kesehatan yang wilayah kerjanya di Desa Antapan, 2) Adanya prevalensi Infeksi Saluran Pernafasan  Atas pada pasien yang bekerja sebagai petani, dan 3) Kejadian kasus keracunan pestisida  akut pernah ditangani  yang dialami oleh pasien yang merupakan petani di Desa Antapan. Berdasarkan hasil observasi dan wawancara lainnya dengan  masyarakat desa Antapan yang mayoritas bekerja sebagai petani maka ditemukan beberapa hal berikut ini yaitu 1) Petani mengalami keluhan tentang kondisi kesehatan utamanya gangguan saluran pernafasan dengan beberapa diantaranya mengalami gangguan pencernaan, 2) Petani kurang memahami tentang K3 dikarenakan rendahnya pengetahuan mereka serta belum adanya pembinaan K3 bagi mereka yang mereka jadikan sebuah kebutuhan karena adanya kasus keracunan yang pernah terjadi pada petani di wilayah desa Antapan tersebut. Pelatiahn K3 diberikan dalam metode ceramah, diskusi dan praktek pendampingan berlangsung sangat efektif dengan tercapainya tujuan pengabdian berupa peningkatan wawasan. Pada saat dilaksanakan monitoring evaluasi setelah 2 minggu pelaksanaan, masyarakat petani desa Antapan telah menerapkan prinsip K3 pada keseharian mereka melakukan pekerjaannya.
Acknowledgments
Authors: Gross Matthias
Published: February 2017

Nature + Culture relies on a network of volunteer reviewers to ensure the high quality of our publications. The editors thank the following reviewers for their valuable advice and peer reviews of manuscripts in 2016.
Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study
Authors: Valenti Raffaella , Charidimou Andreas , Xiong Li , Boulouis Gregoire , Fotiadis Panagiotis , Ayres Alison , Riley Grace , Kuijf Hugo J. , Reijmer Yael D. , Pantoni Leonardo , Gurol M. Edip , Davidsdottir Sigurros , Greenberg Steven M. , Viswanathan Anand
Published: February 2017

Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23% on Benton Facial Recognition Test [BFRT] and 13.6% on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.
Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer
Authors: Lambracht-Washington Doris , Fu Min , Wight-Carter Mary , Riegel Matthew , Rosenberg Roger N.
Published: February 2017

A pathological hallmark of Alzheimer’s disease (AD) are amyloid plaques in the brain consisting of aggregated amyloid-β 42 peptide (Aβ42) derived from cellular amyloid-β protein precursor (AβPP). Based on successful experiments in mouse AD models, active immunization with Aβ42 peptide and passive immunizations with anti-Aβ42 antibodies were started in clinical trials. Active Aβ42 peptide immunization in humans had led to an inflammatory autoimmune response, and the trial was stopped. Passive immunizations had shown some effects in slowing AD pathology. Active DNA Aβ42 immunizations administered with the gene gun into the skin elicits a different immune response and is non-inflammatory. While in rodents, good responses had been found for this type of immunization, positive results in larger mammals are missing. We present here results from sixteen New Zealand White Rabbits, which underwent intradermal DNA Aβ42 immunization via gene gun. The humoral immune response was analyzed from blood throughout the study, and cellular immune responses were determined from spleens at the end of the study. A good anti-Aβ antibody response was found in the rabbit model. The T cell response after re-stimulation in cell culture showed no IFN γ producing cells when ELISPOT assays were analyzed from PBMC, but low numbers of IFN γ and IL-17 producing cells were found in ELISPOTS from spleens (both 5 immunizations). Brains from immunized rabbits showed no signs of encephalitis. Based on these results, DNA Aβ42 immunization is highly likely to be safe and effective to test in a possible clinical AD prevention trial in patients.
Physical Exercise with Music Maintains Activities of Daily Living in Patients with Dementia: Mihama-Kiho Project Part 2
Authors: Satoh Masayuki , Ogawa Jun-ichi , Tokita Tomoko , Nakaguchi Noriko , Nakao Koji , Kida Hirotaka , Tomimoto Hidekazu
Published: February 2017

Background: Recent studies suggest that combined non-pharmacological interventions are more beneficial than single interventions for primary and secondary prevention of dementia. We previously reported enhanced effects of physical exercise with music (ExM) on cognitive function in normal elderly people compared to exercise alone.

Objective: To identify if ExM improves cognitive function and activities of daily livings (ADLs) in dementia patients over cognitive stimulation (CS).

Methods: We enrolled 85 patients with mild to moderate dementia. Forty-three subjects performed ExM developed by the Yamaha Music Foundation, and 42 subjects performed cognitive stimulation using portable game consoles and drills involving easy calculations, mazes, and mistake-searching in pictures. Interventions were performed once a week for 40 minutes. Before and after the six-month intervention, patients were assessed using neuropsychological batteries, and ADLs were assessed by patients’ caregivers using the functional independence measure (FIM). Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) was used to assess medial temporal lobe atrophy.

Results: Twenty-three subjects dropped out during the intervention. Thirty-one patients from each group were analyzed. Post-intervention, both groups showed significantly improved visuospatial function. Significant benefits were observed in psychomotor speed or memory in the ExM or CS groups, respectively. FIM scores, reflecting ADLs, and VSRAD scores were significantly preserved in the ExM group, but significantly worsened in the CS group.

Conclusions: ExM produced greater positive effects on cognitive function and ADLs in patients with mild to moderate dementia than CS, excluding memory. Optimal interventions for dementia will likely be achieved by combining ExMand CS.
Technologies Assessing Limb Bradykinesia in Parkinson’s Disease
Authors: Hasan Hasan , Athauda Dilan S. , Foltynie Thomas , Noyce Alastair J.
Published: February 2017

Background: The MDS-UPDRS (Movement Disorders Society – Unified Parkinson’s Disease Rating Scale) is the most widely used scale for rating impairment in PD. Subscores measuring bradykinesia have low reliability that can be subject to rater variability. Novel technological tools can be used to overcome such issues.

Objective: To systematically explore and describe the available technologies for measuring limb bradykinesia in PD that were published between 2006 and 2016.

Methods: A systematic literature search using PubMed (MEDLINE), IEEE Xplore, Web of Science, Scopus and Engineering Village (Compendex and Inspec) databases was performed to identify relevant technologies published until 18 October 2016.

Results: 47 technologies assessing bradykinesia in PD were identified, 17 of which offered home and clinic-based assessment whilst 30 provided clinic-based assessment only. Of the eligible studies, 7 were validated in a PD patient population only, whilst 40 were tested in both PD and healthy control groups. 19 of the 47 technologies assessed bradykinesia only, whereas 28 assessed other parkinsonian features as well. 33 technologies have been described in additional PD-related studies, whereas 14 are not known to have been tested beyond the pilot phase.

Conclusion: Technology based tools offer advantages including objective motor assessment and home monitoring of symptoms, and can be used to assess response to intervention in clinical trials or routine care. This review provides an up-to-date repository and synthesis of the current literature regarding technology used for assessing limb bradykinesia in PD. The review also discusses the current trends with regards to technology and discusses future directions in development.
Top Altmetric Scores in the Parkinson’s Disease Literature
Authors: Araújo Rui , Sorensen Aaron A. , Konkiel Stacy , Bloem Bastiaan R.
Published: February 2017

A new class of social web-based metrics for scholarly publications (altmetrics) has surfaced as a complement to traditional citation-based metrics. Our aim was to study and characterize those recent papers in the field of Parkinson’s disease which had received the highest Altmetric Attention Scores and to compare this attention measure to the traditional metrics. The top 20 papers in our analysis covered a variety of topics, mainly new disease mechanisms, treatment options and risk factors for the development of PD. The main media sources for these high attention papers were news items and Twitter. The papers were published predominantly in high impact journals, suggesting a correlation between altmetrics and conventional metrics. One paper published in a relatively modest journal received a significant amount of attention, reflecting that public attention does not always parallel the traditional metrics. None of the most influential papers in PD, as reviewed by Ponce and Lozano (2011) made it to our list, suggesting that recent publications receive higher attention scores, and that altmetrics may omit older, seminal work in the field.
Quasi-two-dimensional transition metal dichalcogenides: structure, synthesis, properties, and applications
Authors: Chernozatonskii L A , Artyukh A A
Published: February 2017

Electron states in quasi-two-dimensional (2D) metal and semiconductor crystals can have unusual characteristics and can therefore exhibit unusual electronic and optical properties. In this paper, the results recently obtained for a new class of 2D compounds—transition metal dichalcogenides—are presented, including those on the structure, preparation methods, the electronic, mechanical, and optical properties, defects and their influence on material properties, and conditions facilitating the formation of defects. We consider the unique properties of mono- and multilayer materials, examine their dependence on external factors, and discuss their further application prospects. Various applications of 2D transition metal dichalcogenides are described, ranging from nanolubricants, nanocomposites, biosensors, memory cells and supercapacitors to optoelectronic, spin, and photovoltaic devices.
Hierarchical Self-Assembly of Amino Acid Derivatives into Enzyme-Responsive Luminescent Gel
Authors: Li Yibao , Peng Yu , Liu Wei , Fan Yulan , Wu Yongquan , Li Xun , Fan Xiaolin
Published: February 2017

In this study, a novel three-component hydrogel has been designed and fabricated via hierarchical self-assembly by amino acid derivative (NPPD), riboflavin (RF) and α-cyclodextrin (α-CD). These molecules were aggregated to form some fibrous structures based on hydrogen bond and π–π stacking. The results show that the hydrogel has a specific response to α-amylase and the fluorescence disappears once hydrolyzed. Therefore, this multi-component hydrogel has potential application in the field of drug delivery.
Nanoporous Microtubes via Oxidation and Reduction of Cu–Ni Commercial Wires
Authors: Marano Emanuele , Castellero Alberto , Baricco Marcello
Published: February 2017

Metallic porous microtubes were obtained from commercial wires (200–250 µm diameter) of Cu-65Ni-2Fe, Cu-44Ni-1Mn and Cu-23Ni, alloys (wt. %) by surface oxidation at 1173 K in air, removal of the unoxidized core by chemical etching, and reduction in annealing in the hydrogen atmosphere. Transversal sections of the partially oxidized wires show a porous layered structure, with an external shell of CuO (about 10 μm thick) and an inner layer of NiO (70–80 μm thick). In partially oxidized Cu-44Ni-1Mn and Cu-23Ni, Cu2O is dispersed in NiO because the maximum solubility of Cu in NiO is exceeded, whereas in Cu-65Ni-2Fe, a Cu2O shell is present between CuO and NiO layers. Chemical etching removed the unoxidized metallic core and Cu2O with formation of porous oxide microtubes. Porosity increases with Cu content because of the larger amount of Cu2O in the partially oxidized wire. After reduction, the transversal sections of the metallic porous microtubes show a series of f.c.c.-(Cu,Ni) solid solutions with different compositions, due to the segregation of CuO and NiO during oxidation caused by the different diffusion coefficients of Ni and Cu in the respective oxides. Pore formation occurs at each step of the process because of the Kirkendall effect, selective phase removal and volume contraction.
Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal
Authors: Sobral Filipa , Calhelha Ricardo , Barros Lillian , Dueñas Montserrat , Tomás Andreia , Santos-Buelga Celestino , Vilas-Boas Miguel , Ferreira Isabel
Published: February 2017

Bee bread (BB) is a fermented mixture of plant pollen, honey, and bee saliva that worker bees use as food for larvae, and for young bees to produce royal jelly. In the present study, five BB samples, collected from Apis mellifera iberiensis hives located in different apiaries near Bragança, in the northeast region of Portugal, and one BB commercial sample were characterized by high-performance liquid chromatography coupled to a diode array detector and electrospray mass spectrometry (HPLC-DAD-ESI/MS) in terms of phenolic compounds, such as flavonoid glycoside derivatives. Furthermore, the samples were screened, using in vitro assays, against different human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), HeLa (cervical carcinoma) and HepG2 (hepatocellular carcinoma), and also against non-tumor liver cells (porcine liver cells, PLP2). The main phenolic compounds found were flavonol derivatives, mainly quercetin, kaempferol, myricetin, isorhamnetin and herbacetrin glycoside derivatives. Thirty-two compounds were identified in the six BB samples, presenting BB1 and BB3 with the highest contents (6802 and 6480 µg/g extract, respectively) and the highest number of identified compounds. Two isorhamnetin glycoside derivatives, isrohamnetin-O-hexosyl-O-rutinoside and isorhamnetin-O-pentosyl-hexoside, were the most abundant compounds present in BB1; on the other hand, quercetin-3-O-rhamnoside was the most abundant flavonol in BB3. However, it was not possible to establish a correlation between the flavonoids and the observed low to moderate cytotoxicity (ranging from >400 to 68 µg/mL), in which HeLa and NCI-H460 cell lines were the most susceptible to the inhibition. To the authors’ knowledge, this is the first report characterizing glycosidic flavonoids in BB samples, contributing to the chemical knowledge of this less explored bee product.
Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons
Authors: Yanez Andy , Harrell Telvin , Sriranganathan Heather , Ives Angela , Bertke Andrea
Published: February 2017

Herpes simplex viruses (HSV1 and HSV2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease. Previous studies showed that nerve growth factor (NGF) maintains HSV1 latency in embryonic sympathetic and sensory neurons. However, adult sensory neurons are no longer dependent on NGF for survival, some populations cease expression of NGF receptors postnatally, and the viruses preferentially establish latency in different populations of sensory neurons responsive to other neurotrophic factors (NTFs). Thus, NGF may not maintain latency in adult sensory neurons. To identify NTFs important for maintaining HSV1 and HSV2 latency in adult neurons, we investigated acute and latently-infected primary adult sensory trigeminal (TG) and sympathetic superior cervical ganglia (SCG) after NTF removal. NGF and glial cell line-derived neurotrophic factor (GDNF) deprivation induced HSV1 reactivation in adult sympathetic neurons. In adult sensory neurons, however, neurturin (NTN) and GDNF deprivation induced HSV1 and HSV2 reactivation, respectively, while NGF deprivation had no effects. Furthermore, HSV1 and HSV2 preferentially reactivated from neurons expressing GFRα2 and GFRα1, the high affinity receptors for NTN and GDNF, respectively. Thus, NTN and GDNF play a critical role in selective maintenance of HSV1 and HSV2 latency in primary adult sensory neurons.
Water Plume Temperature Measurements by an Unmanned Aerial System (UAS)
Authors: DeMario Anthony , Lopez Pete , Plewka Eli , Wix Ryan , Xia Hai , Zamora Emily , Gessler Dan , Yalin Azer
Published: February 2017

We report on the development and testing of a proof of principle water temperature measurement system deployed on an unmanned aerial system (UAS), for field measurements of thermal discharges into water. The primary elements of the system include a quad-copter UAS to which has been integrated, for the first time, both a thermal imaging infrared (IR) camera and an immersible probe that can be dipped below the water surface to obtain vertical water temperature profiles. The IR camera is used to take images of the overall water surface to geo-locate the plume, while the immersible probe provides quantitative temperature depth profiles at specific locations. The full system has been tested including the navigation of the UAS, its ability to safely carry the sensor payload, and the performance of both the IR camera and the temperature probe. Finally, the UAS sensor system was successfully deployed in a pilot field study at a coal burning power plant, and obtained images and temperature profiles of the thermal effluent.
Les inhumations et les dépôts d’animaux en fosses circulaires du Néolithique récent du sud de la plaine du Rhin supérieur
Authors: Lefranc Philippe , Denaire Anthony , Chenal Fanny , Arbogast Rose-Marie
Published: February 2017

This article presents a synthetic analysis of the human and animal burials in circular pits attributed to the late Neolithic of the southern plain of the Upper Rhine. It is based on new, often unpublished, data resulting from preventive excavations. The large regional corpus allows us to reveal several recurrent traits that permit the study of a complex system with the coexistence of regular, simple inhumations, simultaneous burials associating individuals in a regular position and bodies in disorderly positions, successive burials and secondary burials. The discovery of human bodies and animal carcasses, which were the object of post-decompositional manipulations, allows us to reconstruct a complex act that could be similar to that observed in numerous enclosure wall trenches. We also address the question of the possible existence of human burials realized outside of the funerary context, based on the association of a non prepared body and a deposit of copper objects. A confrontation of the model with data from other regions, notably the Rhone Valley and Germany, allow us to insist on the coherence of the phenomenon of burials in circular pits from one extremity to the other of its zone of distribution.
Pour réécrire la fin du Néolithique dans le sud-est de la France : bilan critique sur cent années d’études
Authors: Cauliez Jessie
Published: February 2017

Dans l’arc méditerranéen français, cela fait maintenant plus d’un siècle que les chercheurs en Préhistoire récente portent toute leur attention sur l’élaboration du cadre chronoculturel, ouvrage pour lequel les formes céramiques et les styles décoratifs ont été de première importance pour rendre compte de l’existence d’entités culturelles d’extension géographique circonscrite développant des traits originaux. Cet article propose une remise à plat de toute la documentation régionale et une lecture historiographique de la fin du Néolithique, dans le but de décortiquer les théories en cours sur cette période et leur utilisation dans la construction d’un système explicatif pour lequel, malgré ces honorables années de recherche, tout ou partie des démonstrations repose encore trop souvent sur l’accumulation d’hypothèses empiriques échafaudées sans réactualisation. L’histoire de la construction du canevas chronoculturel du sud-est de la France est ainsi retracée de façon critique en trois grandes parties pour dégager les fondements valides et les incertitudes sur les questions d’origine, d’évolution, de transformation et d’imbrication des groupes est-rhodaniens. La démonstration montre notamment la primauté languedocienne dans les schémas de formation des groupes provençaux et donc les liens plus ou moins forts dans les relations envisagées entre les cultures de part et d’autre du Rhône. En explorant la dimension géographique donnée à ces groupes et celle de la pertinence de l’échelle à laquelle ils sont définis, la lumière est faite aussi sur la difficulté à ordonner les cultures de manière à rendre compte de leur renouvellement et de leurs différentes variations spatiales (faciès) et chronologiques (possibilité de phasage interne). Enfin, la réintégration des données sur la fin du Néolithique pour un secteur allant de l’Italie centrale au Languedoc oriental et de la côte méditerranéenne jusqu’aux lacs de Suisse occidentale est l’occasion de présenter et de coordonner des informations de sphères géoculturelles variées pour se préoccuper de la réinscription du Néolithique final de Provence dans un cadre beaucoup plus global. L’article s’achève alors sur les premières orientations que nous proposons de suivre dans la résolution des problèmes mis en évidence tout au long de cette lecture croisée.
Les fouilles récentes du Pech de l’Azé IV (Dordogne)
Authors: Turq Alain , Dibble Harold Lewis , Goldberg Paul , McPherron Shannon P. , Sandgathe Dennis M. , Jones Heather L. , Maddison Kerry , Maureille Bruno , Mentzer Suzanne , Rink Jack W. , Steenhuyse Alexandre
Published: February 2017

Le gisement moustérien du Pech de l’Azé IV se situe à Carsac (Dordogne) en Périgord, près de Sarlat, dans le sud-ouest de la France. Fouillé par F. Bordes durant les années 1970, il n’a jamais été véritablement publié si l’on excepte l’étude que nous avons consacrée en 2000 au matériel issu de ses fouilles. Les travaux de terrain effectués dans ce gisement entre 2000 et 2003 avaient pour but de faire une nouvelle lecture stratigraphique, de préciser les processus de formation du site et de dater la séquence. Nous présentons ici les premiers résultats concernant la géologie, ainsi qu’une description rapide des industries et les premières dates ESR, le programme engagé étant toujours en cours. L’étude microscopique et macroscopique détaillée des huit principales couches stratigraphiques révèle que les dépôts sableux proviennent d’un même et vaste système de grottes englobant probablement l’ensemble des sites moustériens du Pech de l’Azé (I, II et IV). Le niveau inférieur, dépôt sombre et organique, est particulièrement intéressant. Il renferme de multiples surfaces de combustion souvent piétinées et peut-être des vidanges de foyers. Bien que déposés sous un climat tempéré, les sédiments d’origine anthropique sont bien conservés. Si, dans la séquence, l’observation macroscopique a permis d’identifier des phénomènes de solifluxion, l’analyse microscopique n’a montré pratiquement aucun indice d’un climat froid. En ce qui concerne les industries, les nouvelles séries sont globalement comparables aux anciennes. Toutefois, quelques nouveaux éléments sont apparus, notamment la présence d’une technologie Quina dans la partie supérieure de la séquence.
L'architecture et les occupations du Bronze final 1 et du Bronze final 2b du site du Gournier, secteur de Fortuneau, à Montélimar (Drôme)
Authors: Vital Joël , Berger J.-F. , Brochier Jacques Léopold , Argant Thierry , Beeching Alain , Vital Annie
Published: February 2017

The rescue excavation of the site of Fortuneau, though still in progress, has provided an opportunity to apply precise excavation and sedimentary analysis methods to large surfaces of a habitat occupied two times during the Final Bronze Age. This double methodology compensates for the limits imposed by the instability of anthropogenic structures and post-depositional processes. The chronological distinction is based on stratigraphic data, pottery reference assemblages and radiocarbon dates. In BF1 and BF2b, we find architectural structures with supporting posts, which are still poorly known in the south-east. These constructions are associated with various anthropogenic sedimentary forms that suggest the possibility of horticultural practices nearby. An isolated building found in the Final Bronze Age 1 corresponds well to similar finds in the Prealps. The cultural components of the pottery assemblage correlates, with a few differences in two excavation zones, with the Rhône Basin, and more broadly, the Rhône-Saône-Jura zone, as well as the Midi and Alps zones. At the scale of the vast site of Gournier, different scattered installations that could correspond to a series of farms were discovered. In the Final Bronze Age 2, a town expanded to cover a large surface, though its true extension remains unknown. Its organization corresponds to that often observed in the Rhône Bronze Age. In particular, we find the coexistence of several architectural ensembles composed of a habitation building associated with one or two possible agricultural buildings. A series of granaries on posts is concentrated at the junction between a sector in which we observe rather isolated and close architectural groups and a sector in which the spaces between buildings clearly tend to become smaller. This configuration corresponds to the evolutionary scheme of land habitats in the north-east Alpine zone during the Final Bronze Age, with a trend toward the grouping together of houses and the concentrationdensification of the town, but whose extension toward the Midi is a new element that raises new questions. This phenomenon, which concerned the Jurassian zone of the eastern Rhine-Switzerland-France culture, contradicts the hypothesis of a Rhône and Languedoc cultural group whose limits would be suggested by the recurrent presence of numerous pottery types. It would thus appear that these architectural choices were related to symbolic – and political ? – constraints with a greater geographic extension, rather than to cultural expression. The future necessary development of research on the Bronze Age in southern France will allow us to test this hypothesis.
Les Mammifères du département de la Loire. I. Rongeurs et Insectivores
Authors: Aulagnier S. , Coquillart Hervé , Brunet-Lecomte Patrick
Published: February 2017

Le département de la Loire est très hétérogène ; formé de six districts naturels très contrastés, il constitue un terrain d'étude biogéographique privilégié. Corrélativement à l'existence de milieux variés, le peuplement micromammalien (Chiroptères exceptés) est particulièrement riche et diversifié (31 espèces), seules quelques espèces «montagnardes» manquent à notre inventaire. Une discussion sur notre technique d'étude, analyse des proies de Chouette effraie, complète cette synthèse départementale.
Batesiana et Martinezia, nouveaux genres d'Euparini (Coleoptera : Scarabaeidae : Aphodiinae) du nouveau monde
Authors: Chalumeau Fortuné
Published: February 2017

In this paper, the author explains how he has been lead to examine the New World Eupariini types and to revise the tribu of this area, after his antillean Scarabs usual studies and mainly from the Ataenius species inhabiting the West Indies.

Two genus (Batesiana and Martinezia) and two species owning to the second one (Martinezia dutertrei and cambeforti), all new to Science, are described. The remaining species are removed from different genus and assigned to Batesiana (one taxon) and Martinezia (six taxa). Their geographical repartition is given and the biological informations, as published by various authors and mainly for Martinezia dutertrei Chalumeau (excavaticollis Auct.), are reviewed. Two lectotypes plus two paralectotypes are labelled, and two holotypes are pointed. The species aedeagus and different body's parts are figured.
Descriptions et mises au point concernant quelques Morimopsini et Parmenini sud-africains (Coleoptera Cerambycidae Lamiinae)
Authors: Breuning Stephan , Téocchi Pierre
Published: February 2017

Dans cette note, un genre est créé, 2 espèces nouvelles sont décrites tandis qu'une troisième, qui jusqu'ici était considérée comme une variété, est élevée au rang d'espèce.
Contribution synthétique à la taxinomie phylétique des Hyménochétacées porées d'Europe, spécialement du genre Phellinus
Authors: Fiasson Jean-Louis
Published: February 2017

Afin de contribuer à une classification phylogénétique des Hyménochétacées porées, la diversité des approches fut cultivée tant au stade des caractères étudiés qu'à celui du raisonnement taxinomique.

Dans une première partie l'auteur présente la famille botanique étudiée, puis son approche personnelle.

Dans une seconde partie sont exposés résultats expérimentaux et conclusions taxinomiques partielles.

— Données biochimiques :

= distribution des styryl-pyrones dans les basidiocarpes (préliminaire : élucida tion structurale de l'un de ces pigments, l'hypholomine B ; retombée : découverte de deux espèces nouvelles),

= activités enzymatiques des mycéliums secondaires (révélées sur extraits bruts ou après électrophorèse) ;

— Données morphologiques :

= structure macro-et microscopique des basidiocarpes,

= type de culture et comportement nucléaire des mycéliums secondaires. Dans une troisième partie est dégagée la conclusion synthétique de cette étude :

— articulation des Hyménochétacées (ales) en 3 entités Hymenochaeteae (aceae), Phaeoleae (aceae) incluant Coltricia, Phellineae (aceae), dont la microscopie électronique précisera le niveau et les relations,

— subdivision des Phellinus européens en 5 (sous-) genres dont 3 (Cyanovosporus , Fuscoporia, Ochroporus) nouveaux.

Enfin, l'auteur situe et justifie son travail par rapport à l'étude taxinomique des Hyménochétacées considérées à l'échelle mondiale.
Diptères Sciomyzidae : Classification supragénérique et détermination pratique des genres pour l'europe
Authors: Vala Jean-Claude
Published: February 2017

Diptera Sciomyzidae : Suprageneric classification and practical determination of european genus. — There are three subfamilies only included in this classification of Sciomyzidae (Diptera) : Salticellinae Enderlein, 1939, Huttonininae Steyskal, 1965 and Sciomyzinae sensu Steyskal 1965. Validity of genus Knutsonia Verbeke 1964 is discussed and Ilione Haliday 1837 is considered as nomen nudum. An illustrated key is established for the 22 genus of Sciomyzidae which have been found in Europe.
Garidella nigellastrum L., plante énigmatique (Renonculacées)
Authors: Aubin Pierre
Published: February 2017

Garidella nigellastrum L., a strange plant (Ranunculaceae). — Garidella nigellastrum has been found recently growing in two places of Bouches du Rhône (France).
Espèces méridionales françaises non signalées dans «The Polyporaceae of North Europe» de Ryvarden
Authors: David Alix
Published: February 2017

Southern french species non studied in the Ryvarden's book «The Polyporaceae of North Europe». — List of southern french species of Polyporaceae and the main characters to recognize them.
Le genre Leistus Froehlig (Coleoptera - Carabidae - Nebriini). V. Le groupe de Leistus obtusicollis Bates
Authors: Perrault Georges G.
Published: February 2017

Le groupe de Leistus obtusicollis qui fait partie du sous-genre Pogonophorus Latreille, comprend huit espèces qui peuvent se répartir en trois sous-groupes géographiques occupant d'une part l'île de Honshu (Japon) avec trois espèces : L. obtusicollis Bates, L. subaeneus Bates, L. ishikawai n. sp., d'autre part les îles japonaises de Shikoku : L. kosakai n. sp, et de Kyushyu : L. prolongatus Bates et Taïwan : L. niitakaensis Minowa, et enfin l'Himalaya avec une espèce au Sikkim : L. sikkimensis n. sp. et une au Népal : L. lassallei n. sp.