bluuebunny/crossref_metadata_2025 huggingface dataset:
POLA PENGGUNAAN OBAT PADA PASIEN STROKE HEMORAGIK DI RSUP PROF. DR. R.D. KANDOU MANADO PERIODE JANUARI-DESEMBER 2018
Authors: Poana Nony L. , Wiyono Weny I , Mpila Deby A
Published: April 2021

ABSTRACK Hemorrhagic stroke is a stroke caused by intracerebral hemorrhage or subarachniod hemorrhage due to rupture of cerebral blood vessels in certain areas, so that blood fills the brain tissue. The selection and use of drugs must be rational, so that treatment can achieve maximum therapy with minimal side effects. The purpose of this study was to determine the characteristics and patterns of drug use in hemorrhagic stroke patients at Prof. RSUP Dr. R.D. Kandou Manado. This study uses a descriptive method with a retrospective research design. The sample of this study were 83 patients, including 70 intracerebral hemorrhagic stroke patients and 13 subarachnoid hemorrhagic stroke patients. Patient characteristics were mostly male as many as 46 patients (55.42%) and female as many as 37 patients (44.58%). The largest age range of hemorrhagic stroke patients at the age of 55-64 years was 27 patients (32.52%). The duration of treatment with the highest prevalence was 1-5 days in 37 patients (44.57%). Hypertension is the most common comorbid disease of 60 patients (40.27%), and cholesterol of 15 patients (10.06). The pattern of drug use based on the evaluation of the right indication as many as 83 patients (100%), the right patients as many as 83 patients (100%), the right drugs as many as 82 patients (98.8%), and the right dosage of 73 patients (87.95%). Keywords: Hemorrhagic stroke, drug use ABSTRAK Stroke hemoragik adalah stroke yang disebabkan oleh perdarahan intraserebral atau perdarahan subarakhniod karena pecahnya pembuluh darah otak pada area tertentu, sehingga darah memenuhi jaringan otak. Pemilihan dan penggunaan obat harus secara rasional, sehingga pengobatan dapat mencapai terapi yang maksimal dengan efek samping minimal. Tujuan dari penelitian ini untuk mengetahui karakteristik dan pola penggunaan obat pada pasien stroke hemoragik di RSUP Prof. Dr. R.D. Kandou Manado. Penelitian ini menggunakan metode deskriptif dengan desain penelitian retrospektif. Sampel penelitian ini sebanyak 83 pasien, diantaranya terdapat 70 pasien stroke hemoragik intraserebral dan 13 pasien stroke hemoragik subarakhnoid. Karakteristik pasien sebagian besar adalah laki-laki sebanyak 46 pasien (55,42%) dan perempuan sebanyak 37 pasien (44,58%). Rentang usia pasien stroke hemoragik terbesar pada usia 55-64 tahun sebanyak 27 pasien (32,52%). Lama perawatan dengan prevalensi paling banyak, yaitu 1 – 5 hari pada 37 pasien (44,57%). Hipertensi merupakan penyakit penyerta yang paling banyak diderita sebesar 60 pasien (40,27%), dan kolestrol sebanyak 15 pasien (10,06). Pola penggunaan obat berdasarkan evaluasi tepat indikasi sebanyak 83 pasien (100%), tepat pasien sebanyak 83 pasien (100%), tepat obat sebanyak 82 pasien (98,8%), dan tepat dosis sebanyak 73 pasien (87,95%). Kata kunci : stroke hemoragik, pola penggunaan obat
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI KRIM EKSTRAK ETANOL HERBA SELEDRI (Apium graveolens L.) TERHADAP BAKTERI Staphylococcus aureus
Authors: Clements Garry , Yamlean Paulina V. Y. , Lolo Widya Astuty
Published: April 2021

ABSTRACTCelery herbs (Apium graveolens L.) have content flavonoid, saponin and tannin. Flavonoids have anti-inflammatory properties, antioxidants and antibacterials. This study aims to determine whether the ethanol extract of celery herbs can be formulated into cream preparations, test the quality of preparations at concentrations of 5%, 10% and 15%. These methods of research are experimental laboratories by making the supply of self-sustaining herbal celery ethanol extract cream and testing the quality of the cream preparation,  as well as testing of antibacterial activity was carried out using the liquid dilution method and measuring value of  Minimum Inhibitory Concentration  and Minimum Bactericidal Concentration using a UV-Vis Spectrophotometer. This research shows that celery herbs ethanol extract can be formulated into cream preparations, fulfilling quality test of organoleptic, scatter power, adhesion and cycling test, but that doesn’t meet the requirements for homogeneity tests and pH tests and has antibacterial activity which not only inhibits but kills bacteria in preparations of 5% and 15%Keywords: Cream Celery herb extract, Antibacterial, Staphylococcus aureus, UV-Vis spectrophotometer ABSTRAK Herba Seledri (Apium graveolens L.) memiliki kandungan flavonoid, saponin dan tannin. Flavonoid memiliki khasiat sebagai antiinflamasi, antioksidan dan antibakteri. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol herba Seledri dapat diformulasikan menjadi sediaan krim, menguji mutu sediaan pada konsentrasi 5%, 10% dan 15%. Metode penelitian ini experimental laboratorium dengan membuat Sediaan Krim Ekstrak Etanol Herba Seledri dan menguji mutu sediaan krim, serta   menguji aktivitas antibakteri menggunakan metode dilusi cair dan mengukur nilai KBM dan KHM menggunakan Spektrofotometer UV-Vis. Hasil penelitian menujukkan bahwa ekstrak etanol herba Seledri dapat diformulasikan menjadi sediaan krim, memenuhi uji mutu sediaan organoleptik, daya, sebar, daya hambat dan stabilitas  namun tidak memenuhi persyaratan untuk uji homogenitas dan uji pH serta mempunyai aktivitas antibakteri yang membunuh bakteri pada sediaan berkonsentrasi 5% dan 15%.Kata Kunci : Krim Ekstrak herba Seledri, Antibakteri, Staphylococcus aureus, Spektrofotometer UV-Vis
TINJAUAN PENGGUNAAN DAN POTENSI INTERAKSI OBAT ANTIKEJANG DENGAN OBAT LAIN PADA PASIEN STROKE PERDARAHAN RAWAT INAP RSUP PROF. DR. R. D. KANDOU MANADO
Authors: Porogoi Vionita L. , Wiyono Weny Indayany , Tjitrosantoso Heedy
Published: April 2021

ABSTRACK Hemorrhagic stroke is a stroke caused by intra-cerebral hemorrhage or subarachniod hemorrhage due to rupture of cerebral blood vessels in certain areas so that blood fills the brain tissue. Seizures are the most common neurological problem in stroke patients. The occurrence of seizures due to stroke is believed to be the presence of lesions in the brain during a stroke and the formation of scar tissue. This study discusses the use of anti-seizures and the potential of anti-seizure interactions of hemorrhagic stroke patients in inpatient at RSUP Prof. Dr. R. D. Kandou Manado. This study is involved retrospective data on 30 medical records of stroke patients with Hemorrhage in inpatients that met the inclusion criteria. Phenytoin as many as 23 (76,67%), phenytoin combined with Diazepam can occur as many as 4 (13,33%) and Diazepam by 3 (10%). Drug interactions, phenytoin combined with nicardipine which occurs as many as 2 (40%) interactions occur, phenytoin combined with Diazepam can occur as many as 3 (60%) interactions occur. Based on interactions, pharmacokinetic interactions were 5 (100%) occurrences.  Keywords: Hemorrhagic Stroke, anti-seizures, drug interactions ABSTRAK Stroke hemoragik adalah stroke yang disebabkan oleh perdarahan intraserebral atau perdarahan subaraknoid akibat pecahnya pembuluh darah otak di daerah tertentu sehingga darah mengisi jaringan otak. Kejang adalah masalah neurologis yang paling umum pada pasien stroke. Terjadinya kejang akibat stroke dipercayai adanya lesi di otak selama stroke dan pembentukan jaringan parut. Penelitian ini membahas penggunaan anti-kejang dan potensi interaksi anti-kejang pasien stroke hemoragik di rawat inap di RSUP Prof. Dr. R. D. Kandou Manado. Penelitian ini melibatkan data retrospektif pada 30 catatan medis pasien stroke dengan Perdarahan pada pasien rawat inap yang memenuhi kriteria inklusi. Fenitoin sebesar 23 (76,67%), Fenitoin dikombinasikan dengan Diazepam sebesar 4 (13,33%)., dan Diazepam sebesar 3 (10%). Interaksi obat, fenitoin yang dikombinasikan dengan nicardipine yang terjadi sebanyak 2 (40%) interaksi terjadi, fenitoin yang dikombinasikan dengan Diazepam dapat terjadi sebanyak 3 (60%) interaksi terjadi. Berdasarkan interaksi, interaksi farmakokinetik adalah 5 (100%) kejadian.  Kata kunci: Stroke Hemoragik, anti-kejang, interaksi obat
UJI AKTIVITAS AMARA DARI PRODUK JST TERNAK, PREBIOTIK TERNAK, DAN ASAM AMINO TERNAK TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus L.) GALUR WISTAR
Authors: Sumerah Marsella , Yudistira Adithya , Mansauda Karlah L.R
Published: April 2021

ABSTRACTLivestock  JST Products, Livestock Prebiotic Products, and Livestock Amino Acid Products, are herbal products that have the potential to be used as animal feed which functions to increase appetite in livestock. This study aims to determine the amara activity of male white rats (Rattus norvegicus L.) Wistar strain. The rats were treated with an idealized treatment for Animal JST Products, Animal Prebiotic Products, and Animal Amino Acid Products, as much as 2 ml, every afternoon for 10 days using an oral sonde device and a 5 cc dispo and the treatment group without giving the product as a negative control, which was only given food cattle in the form of concentrate. The results showed that the administration of Animal JST Products, Animal Prebiotic Products, and Animal Amino Acid Products, affected the appetite of Male White Rats (Rattus norvegicus L.) Wistar strain, which was marked by weight gain.Keywords  :     Animal JST Products, Animal Prebiotic Products, Animal Amino Acid Products,        Rattus norvegicus L. ABSTRAK Produk JST Ternak, Produk Prebiotik Ternak, dan Produk  Asam Amino Ternak, merupakan suatu produk herbal yang berpotensi untuk dimanfaatkan sebagai pakan ternak yang berfungsi dapat meningkatkan nafsu makan pada ternak. Penelitian ini bertujuan untuk mengetahui aktivitas amara terhadap Tikus Putih Jantan (Rattus norvegicus L.) Galur Wistar. Tikus diberi perlakuan dioralkan Produk JST Ternak, Produk Prebiotik Ternak, dan Produk Asam Amino Ternak, sebanyak 2 ml, setiap sore selama 10 hari dengan menggunakan alat sonde oral dan dispo 5 cc dan kelompok perlakuan tanpa pemberian produk sebagai kontrol negatif, yang hanya diberikan pakan ternak berupa konsentrat. Hasil menunjukkan bahwa pemberian Produk JST Ternak, Produk Prebiotik Ternak, dan Produk Asam Amino Ternak, berpengaruh terhadap nafsu makan Tikus Putih Jantan (Rattus norvegicus L.) Galur Wistar, yang ditandai dengan kenaikan berat badan.Kata Kunci  : Produk JST Ternak, Produk Prebiotik Ternak, Produk  Asam Amino Ternak,  Rattus norvegicus L.
PERSEPSI PERAWAT TERHADAP PERAN APOTEKER DALAM PELAYANAN KEFARMASIAN DI RUMAH SAKIT ROBERT WOLTER MONGISIDI MANADO
Authors: Dadiani Ni Made , Lolo Widya A , Antasionasti Irma
Published: April 2021

ABSTRACTPharmacy services was one of the supporting activities of health services quality. Majority, the hospitals in Indonesia had not performed Pharmaceutical Care activities in accordance with the Standard of Pharmaceutical Care in Hospital stipulated in regulation of the Minister of Health Republic of Indonesia No. 72 year 2016. The lack of cooperation and communication between pharmacists, nurses and other health workers can cause differences in perception. This studied aims to know the opinions and expectations of nurse to the role of pharmacist in pharmaceutical care at Robert Wolter Mongisidi Hospital Manado. This research was a quantitative descriptive study and data collection tool used was a questionnaire about the opinions and expectations given to 140 nurses. The results showed that perception of nurses tend to agree with an average value of 93,81% for the opinion and for the expectation of 98,16%. The conclusion that the nurse had good opinions and expectation to the role of pharmacists in accordance with Pharmaceutical Care Standards.Key words : Pharmaceutical Care, Nurse Perception, Pharmacists.ABSTRAK Pelayanan farmasi merupakan salah satu kegiatan penunjang pelayanan kesehatan yang bermutu. Sebagian besar Rumah Sakit di Indonesia belum melakukan kegiatan pelayanan farmasi sesuai dengan Standar Pelayanan Kefarmasian di Rumah Sakit yang diatur dalam Peraturan Menteri Kesehatan Republik Indonesia No. 72 Tahun 2016. Kurangnya kerjasama dan komunikasi antara apoteker, perawat dan tenaga kesehatan lain dapat menyebabkan perbedaan persepsi. Penelitian ini bertujuan untuk mengetahui pendapat dan harapan perawat terhadap peran apoteker dalam pelayanan kefarmasian di Rumah Sakit Robert Wolter Mongisidi Manado. Penelitian ini merupakan penelitian deskriptif kuantitatif dan alat pengumpulan data yang digunakan berupa kuesioner tentang pendapat dan harapan yang diberikan kepada 140 perawat. Hasil penelitian menunjukkan bahwa  persepsi perawat cenderung setuju dengan nilai rata-rata untuk pendapat sebesar 93,81% dan untuk harapan sebesar 98,16%. Kesimpulan yang didapat bahwa perawat memiliki pendapat dan harapan yang baik terhadap peran apoteker sesuai dengan Standar Pelayanan Kefarmasian. Kata kunci : Pelayanan Kefarmasian, Persepsi Perawat, Apoteker.
UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lam.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)
Authors: Tamimi Alyah A.P , De Queljoe Edwin , Siampa Jainer P.
Published: April 2021

ABSTRACTAnalgesic medicinals are medicinals that can inhibit pain. Moringa leaves (Moringa oleifera Lam.) are known to contains alkaloid and flavonoid which have analgesic effects.The purpose of this study was to determine the analgesic effects of the ethanol extract of Moringa leaves on male white rats wistar strain (Rattus norvegicus). A total of 15 rats were divided into 5 treatment groups, namely the negative control group (CMC), positive control group (paracetamol), and the group of ethanol extract of Moringa leaves with different doses of 0.1 g, 0.2 g, and 0.4 g. Rat response was observed before giving test material and after giving test material from the 30th, 60th, 90th, and 120th minutes. Data were analyzed using ANOVA then continued with LSD test. The results showed that the ethanol extract of Moringa leaves with dosages of 0.1 g, 0.2 g, and 0.4 g had an analgesic effect on male white rats wistar strain. And among these three doses the best in providing analgesic effect is a dose of 0.4 g. Keywords: Analgesic, Moringa leaf (Moringa oleifera Lam.), Rattus norvegicus. ABSTRAKObat analgesik merupakan obat yang dapat menghambat rasa nyeri. Daun kelor (Moringa oleifera Lam.) diketahui mengandung alkaloid dan flavonoid yang memiliki efek analgesik. Tujuan penelitian ini untuk mengetahui adanya efek analgesik dari ekstrak etanol daun kelor (Moringa oleifera Lam.) pada tikus putih jantan galur wistar (Rattus norvegicus). Sebanyak 15 ekor tikus dibagi 5 kelompok perlakuan, yaitu kelompok kontrol negatif, kelompok kontrol positif, dan kelompok ekstrak etanol daun kelor dengan dosis berbeda 0,1 g, 0,2 g, dan 0,4 g. Respon tikus diamati sebelum pemberian bahan uji dan setelah pemberian bahan uji dari menit ke 30, 60, 90, dan 120. Data dianalisis menggunakan ANOVA kemudian dilanjutkan uji LSD. Hasil penelitian menunjukkan bahwa ekstrak etanol daun kelor  dengan dosis 0,1 g 0,2 g, dan 0,4 g memiliki efek analgesik terhadap tikus putih jantan galur wistar. Dan diantara ketiga pemberian dosis tersebut yang paling baik dalam memberikan efek analgesik yaitu dosis 0,4 g. Kata kunci: Analgesik, Daun Kelor (Moringa oleifera Lam.), Rattus norvegicus.
FORMULASI SEDIAAN SABUN CAIR EKSTRAK ETANOL DAUN TURI (Sesbania grandiflora L.) DAN UJI ANTIJAMUR TERHADAP Candida albicans
Authors: Ering Mariando N. , Yamlean Paulina V. Y. , Antasionasti Irma
Published: April 2021

ABSTRACTThe leaves of Hummingbird (Sesbania grandiflora L.) contain flavonoid compounds, saponins and tannins that are antifungal. This research aims to formulate liquid soap extracts of Hummingbird leaf ethanol and test the effectiveness of the antifungal preparations of the liquid soap of Hummingbird leaf ethanol with a concentration of 4%, 6%, 8%, 10% and 12% of the fungus growth of Candida albicans. This research uses experimental methods. The formulation of this liquid soap of Hummingbird leaf ethanol is conducted organoleptic test, pH, high foam, moisture content, free alkaline content, and type weights. Testing the effectiveness of antifungal to Candida albicans growth is done by diffusion method. Liquid soap preparations of Hummingbird leaf ethanol extract meet the standards set by SNI for organoleptic testing, pH test, Foam High test, water content test, free alkali rate test, and type weight test. Based on the anti-fungal testing of the preparation of a liquid soap extract of Hummingbird leaf ethanol to the fungus Candida albicans obtained the results of all preparations have a resistance to fungi and strong categorized.Keywords:  Hummingbird leaves, Liquid soap, AntifungalABSTRAK Daun Turi (Sesbania grandiflora L.) memiliki kandungan senyawa flavonoid, saponin dan tannin yang bersifat sebagai antijamur. Penelitian ini bertujuan untuk memformulasikan sabun cair ekstrak etanol daun Turi dan menguji efektivitas antijamur sediaan sabun cair ekstrak etanol daun Turi dengan konsentrasi 4%, 6%, 8%, 10% dan 12% terhadap pertumbuhan jamur Candida albicans. Penelitian ini menggunakan metode eksperimental. Formulasi sediaan sabun cair ekstrak etanol daun Turi ini dilakukan pengujian organoleptik, pH, tinggi busa, kadar air, kadar alkali bebas, dan bobot jenis. Pengujian efektivitas antijamur terhadap pertumbuhan Candida albicans dilakukan dengan metode difusi. Sediaan sabun cair ekstrak etanol daun turi memenuhi standar yang ditetapkan SNI pada pengujian organoleptik, uji pH, uji tinggi busa, uji kadar air, uji kadar alkali bebas, dan uji bobot jenis. Berdasarkan pengujian antijamur sediaan sabun cair ekstrak etanol daun Turi terhadap jamur Candida albicans didapatkan hasil semua sediaan memiliki daya hambat terhadap jamur dan dikategorikan kuat.Kata Kunci: Daun Turi, Sabun Cair, Antijamur
UJI AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN JARAK PAGAR (Jatropha curcas L.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR WISTAR YANG DIINDUKSI VAKSIN DPT
Authors: Gosal Angel T. , De Queljoe Edwin , Suoth Elly J.
Published: April 2021

ABSTRACTJatropha curcas L. leaves is plants containing saponins, flavonoid compounds such as kaempferol, nicotoflorin, quersitin, astragalin, ricinin and vitamin C. Flavonoids showed more than one hundred kinds of bioactivity, which is antipyretic, analgesic and anti-inflammatory effects. Several researches informed that flavonoid compound had antipyretic activity. The aim of this study was to examined the effect of ethanolic extract of Jatropha curcas L. leaves as antipyretic on white Wistar male rats (Rattus norvegicus) induced with DPT. There were 15 rats tested, divided into 5 groups that is negative control (CMC 1%), positive control (paracetamol) and treatment group of physic nut leaves extract 200 mg, 400 mg and 800 mg. Every rat was induced by fever using 0,4 ml of DPT vaccine intramuscularly. The temperature was measured before the rats were induced, 2-3 hour after induced and every 30 minute for 3 hours. The data obtained were analyzed by ANOVA (Analysis of Variants) and LSD. The results showed that the dose group of Jatropha curcas L. leaves ethanol extract had comparable activity with positive control of paracetamol in reducing fever. The conclusion was the ethanol extract of Jatropha curcas L. leaves has an antipyretic activity that could reduce temperature on white Wistar male rats at a dose of 200 mg, 400 mg and 800 mg. Keywords: Jatropha curcas L., antipyretic, Rattus norvegicus ABSTRAKDaun Jarak Pagar (Jatropha curcas L.) merupakan tanaman yang mengandung saponin, senyawa flavonoida antara lain kaempferol, nikotoflorin, kuersitin, astragalin, risinin dan vitamin C. Flavonoid menunjukkan lebih dari seratus macam bioaktivitas, antara lain efek antipiretik, analgetik dan antiinflamasi. Penelitian ini bertujuan untuk menguji aktivitas antipiretik ekstrak etanol daun jarak pagar (Jatropha curcas L.) terhadap tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi vaksin DPT. Hewan uji yang digunakan sebanyak 15 ekor dan dibagi menjadi 5 kelompok yaitu kontrol negatif (CMC 1%), kontrol positif (parasetamol) dan kelompok dosis uji yaitu pemberian ekstrak daun jarak pagar 200 mg, 400 mg dan 800 mg. Setiap tikus diinduksi demam dengan vaksin DPT dosis 0,4 ml secara intramuskular. Pengukuran suhu dilakukan sebelum induksi, 2-3 jam setelah pemberian induksi dan setiap 30 menit selama 3 jam. Data yang diperoleh dianalisis dengan menggunakan uji ANOVA (Analysis of Variance) dan uji LSD (Least Significant Different). Hasil penelitian menunjukkan bahwa kelompok dosis ekstrak etanol daun jarak pagar memiliki aktivitas yang sebanding dengan kontrol positif parasetamol dalam menurunkan demam. Kesimpulannya ekstrak etanol daun jarak pagar (Jatropha curcas L.) memiliki aktivitas antipiretik yang dapat menurunkan suhu tubuh pada tikus putih jantan galur wistar (Rattus norvegicus) pada dosis 200 mg, 400 mg dan 800 mg. Kata kunci: Jatropha curcas L., antipiretik, Rattus norvegicus
PERSEPSI DOKTER TERHADAP PERAN APOTEKER DALAM PELAYANAN KEFARMASIAN DI RUMAH SAKIT ROBERT WOLTER MONGISIDI MANADO
Authors: Indiyani Ni Nengah S. , Lolo Widya A. , Rundengan Gerald
Published: April 2021

ABSTRACTServices in the health sector are one of the services that are needed by the community, one of them is service in the field of pharmacy. The therapeutic process of a patient needs collaboration between the pharmacist, physician and other health workers. In some hospitals in Indonesia, they have not implementing all pharmaceutical care activities as regulated in Permenkes No. 72 of 2016. This studied aims to know the opinions and expectations of physician to the role of pharmacist in pharmaceutical care. This research was a quantitative descriptive study and data collection tool used was a questionnaire about the opinions and expectations given to 63 physician. Based on the research results obtained, it was known that the perception of physician tend to agree with an average value of 94,55% for the opinion and for the expectation of 91,78%. So that can be concluded that physician had good opinions and expectation to the role of pharmacists in accordance with Pharmaceutical Care Standards.Key words : Pharmaceutical Care, Physician Perception, Pharmacists.ABSTRAK Pelayanan dalam bidang kesehatan merupakan salah satu pelayanan yang banyak di butuhkan oleh masyarakat, salah satunya adalah pelayanan dalam bidang kefarmasian. Proses terapi seorang pasien perlu adanya kerjasama antara apoteker, dokter dan tenaga kesehatan lainnya. Pada beberapa rumah sakit di Indonesia belum melakukan seluruh kegiatan pelayanan farmasi sebagaimana yang sudah di atur dalam Permenkes No. 72 Tahun 2016. Penelitian ini bertujuan untuk mengetahui pendapat dan harapan dokter terhadap peran apoteker dalam pelayanan kefarmasian. Penelitian ini merupakan penelitian deskriptif kuantitatif dan alat pengumpulan data yang digunakan berupa kuesioner tentang pendapat dan harapan yang diberikan kepada 63 dokter. Berdasarkan hasil penelitian yang diperoleh, diketahui bahwa  persepsi dokter cenderung setuju dengan nilai rata-rata untuk pendapat sebesar 94,55% dan untuk harapan sebesar 91,78%. Sehingga dapat disimpulkan bahwa dokter memiliki pendapat dan harapan yang baik terhadap peran apoteker sesuai dengan Standar Pelayanan Kefarmasian. Kata kunci : Pelayanan Kefarmasian, Persepsi Dokter, Apoteker.
UJI AKTIVITAS ANTIOKSIDAN KARANG LUNAK (Nepthea sp.) DENGAN MENGGUNAKAN METODE DPPH (1,1-difenil-2-pikrilhidrazil)
Authors: Langi Priski , Yudistira Adithya , Mansauda Karlah L.R
Published: April 2021

ABSTRACTSoft corals (Nepthea sp.) are soft corals that have the ability to be antibacterial and anticancer. These chemical compounds are the result of secondary metabolites of living organisms that are often known as natural products, which are generally in the form of terpenoids. This study aims to analyze the antioxidant activity of Nepthea sp. Soft Coral (Nepthea sp.) Samples were obtained from Bangka Island waters, Likupang. This research is an experimental laboratory with maceration as method of extraction. Testing of ethanol extracts of soft corals (Nepthea sp.) was using the DPPH method (1,1-diphenyl-2-picrylhydrazy) with concentrations of 25, 50, 75, 100, 125, 150 mg / L to analyze antioxidant activity using a spectrophotometer. The greatest antioxidant level is found in Nepthea sp. with a concentration of 150mg/L. The results of this study showed that the antioxidant levels of Nepthea sp. from Bangka waters have antioxidant activity and the higher of the concentration the higher the antioxidant levels produced.  Keywords: Activity, Antioxidants, DPPH, Nepthea sp. ABSTRAK Karang lunak (Nepthea sp.) adalah karang lunak yang mempunyai kemampuan sebagai antibakteria dan antikanker. Senyawa kimia tersebut merupakan hasil metabolit sekunder organisme hidup yang sering dikenal dengan natural producty yang umumnya berupa terpenoid. Penelitian ini bertujuan untuk menganalisis aktivitas antioksidan dari Nepthea sp. Sampel Karang Lunak (Nepthea sp.) diperoleh dari perairan Bangka, Likupang. Penelitian ini merupakan eksperimental laboratorium dengan metode ekstraksi maserasi pengujian terhadap ekstrak etanol karang lunak (Nepthea sp.) menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazi) dengan kosentrasi 25, 50, 75, 100, 125, 150 mg/L untuk menganalisis aktivitas antioksidan dengan menggunakan spektrofotometer. Kadar antioksidan yang paling besar terdapat pada Nepthea sp. dengan konsentrasi 150mg/L. Hasil penelitian ini memperlihatkan kadar antioksidan Nepthea sp. di perairan Bangka mempunyai aktivitas antioksidan dan semakin tinggi konsentrasi semakin tinggi pula kadar antioksidan yang dihasilkan. Kadar antioksidan yang paling besar terdapat pada Nepthea sp. dengan konsentrasi 150 mg/L.Kata Kunci  : Aktivitas, Antioksidan, DPPH, Nepthea sp.
UJI EFEKTIVITAS FORMULASI SEDIAAN KRIM EKSTRAK KULIT BUAH PISANG GOROHO (Musa acuminafe L.) TERHADAP BAKTERI Staphylococcus aureus
Authors: Pangemanan Stephany P. , Edy Hosea J. , Rumondor Erladys M.
Published: April 2021

ABSTRACT Goroho Banana Skin (Musa acuminafe L.) is a plant that contains flavonoid compounds, saponins and tannins that can inhibit bacterial growth. This study aims to test the antibacterial effectiveness of ethanol extract cream of goroho banana peel and evaluate the preparations using parameters of physical properties and physical stability. This research uses laboratory experimental methods. Cream formula is made with a variety of ethanol extract concentrations of Goroho Banana peel 2.5%, 5%, 7.5%, 10%, 12.5%. Goroho Banana peel extract was obtained by maceration using 96% ethanol solvent. The study of antibacterial test of ethanol extract of Goroho Banana peel using wells method on Staphylococcus aureus bacteria resulted in inhibition of 7.03 ± 3.29 mm at a concentration of 12.5%. All tests are carried out before and during the cycling test. The results obtained before and during the cycling testshowed that the cream preparations met organoleptic requirements, homogeneity, cream pH 6.807 (4.5-6.5), cream adhesion 9.63 seconds (<4 seconds), cream spread 4, 53 cm (5-7 cm). It can be concluded that the ethanol extract of Goroho Banana peel cream meets stable physical test parameters and has moderate antibacterial activity. Keywords: Goroho Banana Peel (Musa acuminafe L.), Antibacterial, Cream. ABSTRAK Kulit Buah Pisang Goroho (Musa acuminafe L.) merupakan tanaman yang mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan krim ekstrak etanol kulit buah pisang goroho dan mengevaluasi sediaan dengan menggunakan parameter uji sifat fisik dan stabilitas fisik. Penelitian ini menggunakan metode eksperimental laboratorium, Formula sediaan krim dibuat dengan variasi konsentrasi ekstrak etanol kulit buah Pisang Goroho 2,5%, 5%, 7,5%, 10%, 12,5%. Ekstrak kulit buah Pisang Goroho diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Penelitian uji antibakteri sediaan krim esktrak etanol kulit buah Pisang Goroho menggunakan metode sumuran pada bakteri Staphylococcus aureus menghasilkan daya hambat 7,03±3,29 mm pada konsentrasi 12,5%. Semua pengujian dilakukan sebelum dan selama cycling test. Hasil penelitian yang didapat sebelum dan selama cycling test menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptis, homogenitas, pH krim 6,807 (4,5-6,5), daya lekat krim 9,63 detik (<4 detik), daya sebar krim 4,53 cm (5-7 cm). Dapat disimpulkan bahwa sediaan krim ekstrak etanol kulit buah Pisang Goroho memenuhi parameter uji fisik stabil dan memiliki aktivitas  antibakteri yang sedang. Kata kunci : Kulit Buah Pisang Goroho (Musa acuminafe L.), Antibakteri, Krim.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BULBUS BAWANG DAYAK (Eleutherine americana Merr) DENGAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl)
Authors: Mokoginta Rizkah V. , Simbala Herny E. I. , Mansauda Karlah L.R
Published: April 2021

ABSTRACTDayak onion plant (Eleutherine americana Merr.) or commonly called forest onion is a typical plant of Central Kalimantan that has been used by local peoples for cure a various types of diseases. This study aims to determine the activity of antioxidant compounds from Dayak bulb ethanol extracts from Kotamobagu City. This research method is an experimental laboratory. Initially the Dayak bulb sample was extracted maceration with 96% ethanol solvent then evaporated until a thick extract was obtained. As a parameter, the DPPH method (1,1-diphenyl-2-picrylhydrazyl) was used to test the antioxidant activity of the samples at concentrations of 50, 60, 70, 80 and 90 mg / L and as a comparison standard used Vitamin C with concentrations of 2, 4, 6, 8 and 10 mg / L. The results obtained showed antioxidant activity in Dayak bulb ethanol extracts with IC50 values of 41.46 mg / L and on vitamin C IC50 values of 1.04 mg / L. Based on these results it can be concluded that the onion bulb ethanol extract has very strong antioxidant activity. Keywords: Dayak Onion bulbs, Activity, Antioxidant, DPPH  ABSTRAK Tanaman bawang Dayak (Eleutherine americana Merr.) atau biasa disebut bawang hutan merupakan tanaman khas Kalimantan Tengah yang sudah dipergunakan masyarakat lokal sebagai obat berbagai jenis penyakit. Penelitian ini bertujuan untuk mengetahui aktivitas senyawa antioksidan dari ekstrak etanol bulbus bawang Dayak yang berasal dari Kota Kotamobagu. Metode penelitian ini adalah eksperimental laboratorium. Awalnya sampel bulbus bawang Dayak diekstraksi maserasi dengan pelarut etanol 96% kemudian dievaporasi hingga didapatkan ekstrak kental. Sebagai parameter, digunakan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) untuk pengujian aktivitas antioksidan sampel pada konsentrasi 50, 60, 70, 80 dan 90 mg/L dan sebagai standar pembanding digunakan Vitamin C dengan konsentrasi 2, 4, 6, 8 dan 10 mg/L. Hasil penelitian yang didapat menunjukkan aktivitas antioksidan pada ekstrak etanol bulbus bawang Dayak dengan nilai IC50 sebesar 41,46 mg/L dan pada vitamin C nilai IC50 sebesar 1,04 mg/L. Berdasarkan hasil tersebut dapat disimpulkan bahwa ekstrak etanol bulbus bawang Dayak memiliki aktivitas antioksidan yang sangat kuat. Kata kunci: Bulbus Bawang Dayak, Aktivitas, Antioksidan, DPPH
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BAWANG DAYAK (Eleutherine americana Merr) TERHADAP BAKTERI Staphylococcus aureus, Escherichia coli DAN Salmonella typhi
Authors: Putri Rafi’a Adinda , Simbala Herny E.I. , Mpila Deby A.
Published: April 2021

ABSTRACTDayak onions (Eleutherine americana Merr) has been used as a traditional plant which has  benefits  for  many  diseases,  one  of  them  is  antibacterial. This study aims to determine the growth inhibition of ethanol extract of Dayak onions leaves on the bacterium S. aureus, E. coli and  S. typhi using three concentrations of 20%, 40% and 60%. Extraction was done by maceration method using ethanol 96%. Antibacterial activity test was performing using the paper disk diffusion method (Kirby-Bauer diffusion). The results showed that ethanol extract of bawang dayak has the potential as an antibacterial and has antibacterial strength against S. aureus, E. coli and S. typhi. At concentrations of 20%, 40% and 60% forming inhibition zone diameters (16.23 mm, 19.18 mm, 21.25 mm) S. aureus, (10.7 mm, 13.98 mm, 15.87 mm) E. coli, and  (14.43 mm, 14.6 mm, 17.2 mm) S. typhi. At concentration of 20%, 40% and 60% included strong groups to inhibit E. coli and  S. typhi, while at concentration of 60%, it is included in a very strong group to inhibit the S. aureus bacteria. Keywords: Antibacterial activity, Bawang Dayak , Kirby-Bauer diffusion method   ABSTRAK Bawang Dayak (Eleutherine americana Merr) telah digunakan sebagai tanaman tradisional yang bermanfaat bagi banyak penyakit salah satunya sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui ekstrak etanol bawang dayak terhadap bakteri S. aureus, E.coli dan S. typhi menggunakan tiga kosentrasi yaitu 20%, 40% dan 60%. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 96%. Pengujian aktivitas antibakteri dilakukan dengan  menggunkan metode difusi dengan cakram kertas (difusi Kirby-Bauer). Hasil penelitian menunjukkan bahwa ekstrak etanol bawang dayak berpotensi sebagai antibakteri dan memiliki kekuatan antibakteri terhadap S. aureus, E. coli dan S. typhi. Pada konsentrasi 20%, 40% dan 60% membentuk diameter zona hambat (16.23 mm, 19.18 mm, 21.25 mm) pada S. aureus, (10.7 mm, 13.98 mm, 15,87 mm) pada E. coli, (14.43 mm, 14.6 mm, 17.2 mm) pada S. typhi. Pada konsentrasi 20%, 40% dan 60% termasuk golongan kuat untuk menghambat bakteri E. coli dan S. typhi, sedangkan pada konsentrasi 60% termasuk dalam golongan sangat kuat untuk menghambat bakteri S. aureus. Kata kunci: Aktivitas antibakteri, Bawang Dayak, metode difusi Kirby-Bauer
PCR-RFLP Design for Authentication of Red Snapper Species Based on CYB Gene
Authors: Timbuleng Kevin , Kolondam Beivy J , Katili Deidy
Published: April 2021

The PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) technique is a species identification method that can facilitate food inspection agencies to overcome mislabelling. In addition, this technique is simple, fast, powerful, and cheap compared to DNA barcodes. This study aimed to accommodate the problem in determining restriction endonuclease enzymes for the digestion of PCR end products through the design of snapper species authentication using the CYB gene in silico. Differentiation of CYB gene sequences with DNA barcoding showed that all species could be differentiated with the highest similarity level in Red Fish (Sebastes) species by 98.9% and snapper species between L. malabaricus and L. erythropterus by 99.8%. Enzyme tracing based on sequences variation of snapper species with substitution species found three potential enzymes from the CYB gene sequence, namely, Accl, Fnu4HI, and Tsp45I. Where all these enzymes can discriminate red snapper species among other.Key words: PCR-RFLP; CYB gene; Red snapperAbstrakTeknik PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) merupakan metode identifikasi spesies yang dapat memfasilitasi lembaga inspeksi makanan untuk mengatasi mislabelling. Selain itu, teknik ini sederhana, cepat, kuat, dan murah dibandingkan dengan barcode DNA. Penelitian ini bertujuan untuk mengakomodasi masalah dalam menentukan enzim restriksi endonuklease untuk digesti produk akhir PCR lewat perancangan autentikasi spesies ikan kakap menggunakan gen CYB secara in silico. Diferensiasi sekuens gen CYB dengan DNA barcoding menunjukkan semua spesies dapat dibedakan dengan tingkat kesamaan tertinggi pada spesies Red Fish (Sebastes) sebesar 98,9% dan spesies kakap antara L. malabaricus dan L. erythropterus sebesar 99,8%. Penelusuran enzim berdasarkan variasi sekuens spesies kakap dengan spesies substitusi ditemukan sebanyak tiga enzim yang berpotensi yaitu, Accl, Fnu4HI, dan Tsp45I. Semua enzim tersebut dapat memdiskriminasikan spesies kakap merah dari spesies lainnya.Kata kunci: PCR-RFLP; gen CYB; ikan kakap merah
Optimization of Sowing Dates and Seeding Rates with Adaptive Control of The Technology of Cultivation of Winter Barley Varieties Mavlono
Authors: Yarkulova* Zulayho , Kadirov Abbos
Published: April 2021

One of the determining periods in the life of winter
cereal plants is sowing (autumn). Only under the condition of
good moisture supply and at optimal air temperature, timely and
high-quality seedlings can be obtained, tillering shoots and
processes of verbalization and hardening of plants to be formed.
Based on the importance of the foregoing, this work presents the
results of studies in bright gray-earth soils of the Kashkadarya
region of the reaction of winter barley of the Mavlono variety for
different periods of sowing and seed sowing rate. It was found that
plant survival ranged from 86.0 to 89.9%. No significant
differences in wintering of plants between crops of different
sowing dates were revealed. Seeding rates did not significantly
affect the height of plants, spike length and the number of grains
in it, which confirms the high plasticity of winter wheat of the
Mavlono variety. Our studies have shown that for winter barley of
the Mavlono variety in the conditions of the Kashkadarya region,
the sowing season is favorable – from 15 October to 1 November,
with an optimum sowing rate of 4 million pcs / ha.
Method of Group Decision Making for Production Planning of the Oil Refinery Plant
Authors: Seyfi Shixaliyev Kerem , Səlimov Vaqif.H.
Published: April 2021

This article is devoted to the problem of decision
making under uncertainty. An aggregated approach is used that
combines optimization and choice of a solution, which makes it
possible to obtain a more realistic solution. The criteria in the
vector optimization problem are: profit, product quality, employee
satisfaction. To solve the optimization problem, 3 methods were
used: "Goal programming", "Interactive", "FMOLP". The task
of group decision making is implemented on the basis of the
package FGDSS-CD (Fuzzy group Decision Support System).
Deep Convolutional Generative Modeling for Artificial Microstructure Development of
Aluminum-Silicon Alloy
Authors: Mishra Akshansh , Pathak Tarushi
Published: April 2021

Machine learning which is a sub-domain of an
Artificial Intelligence which is finding various applications in
manufacturing and material science sectors. In the present study,
Deep Generative Modeling which a type of unsupervised machine
learning technique has been adapted for the constructing the
artificial microstructure of Aluminium-Silicon alloy. Deep
Generative Adversarial Networks has been used for developing the
artificial microstructure of the given microstructure image
dataset. The results obtained showed that the developed models
had learnt to replicate the lining near the certain images of the
microstructures.
A CLINICAL STUDY ON VARIOUS PRESENTATION AND MANAGEMENT OF ACUTE INTESTINAL OBSTRUCTION
Authors: Birla Mohit , Jakhar Heeralal , Bagra Amit , Verma Siddhartha
Published: April 2021

BACKGROUND: The diagnosis and management of patient with intestinal obstruction is one of the more challenging emergency that a general surgeon can come across. With better understanding of pathophysiology, improvement in diagnostic techniques, uid and electrolyte correction, much potent antibiotics and surgical management the complications arising due to late presentation can be limited. AIMS AND OBJECTIVES: To analyze different modes of presentation, various etiological factors of acute intestinal obstruction and to evaluate the different lines of management and its outcome. METHDOLOGY: This study was conducted in M.B Government Hospital attached to R.N.T. Medical College Udaipur. 50 patients fullling the inclusion criteria were part of this study. RESULTS: Intestinal obstruction is more common in the age group of 41-50 years. Male to female ratio is 2.6:1. Small bowel obstruction is more common than large bowel obstruction. Four cardinal features of intestinal obstruction are pain abdomen, vomiting, distension and constipation. Most common etiological factor is postoperative adhesions followed by abdominal hernia. Malignancy as a cause for obstruction is more common in large bowel than small bowel. Most patients were treated by operative procedure in comparison to conservative management; adhesiolysis (14 cases) was carried out commonly. CONCLUSION: Obstruction due to adhesions is increasing in incidence due to increased abdominal & pelvic surgeries. The obstruction due to external hernias is decreasing due to early elective surgeries. The morbidity and mortality depends on the age of the patient, etiology of obstruction, site of obstruction, state of hydration, viability of the bowel, delay in diagnosis and surgical intervention and associated medical illness. Early diagnosis of possible strangulation will markedly decrease morbidity and mortality.
SURGICAL SITE INFECTIONS AFTER OPERATIVE DELIVERY AT THE TERTIARY CARE HOSPITAL IN RAJASTHAN, THEIR MICROBIOLOGICAL PROFILE, ANTIBIOTIC SENSITIVITY AND CLINICAL RISK FACTORS
Authors: Naz Ruby , Meena Krishna
Published: April 2021

Introduction: Surgical site infections (SSI) are common problem in developing country like India. There are so many factors are responsible for
SSI like low immunity, prolonged labour, production of hematoma presence of gestational diabetes Anaemia, multiparaty, heavy blood loss during
delivery. Methods: It is a case-control study undertaken for a period of one year in a tertiary care hospital of Rajasthan state, India. The study
population included patients suffering from SSIs in the various unit of obstetrics ward of our hospital. Result: in our study we found a lot of factor
affecting prevalence of SSIs like anaemia, premature rupture of membrane, prolonged labour, multiparity and obesity. Common organism are
Escherichia coli, staphylococcus and pseudomonas. Most of the organism are susceptible with carbapenems vancomycin and amikacin.
Conclusion: Even though the total number of Cesarean delivery has increasing consistently, wound infection should be has remained less constant.
This may be achieved by high compliance among the infection control practices by health care workers in the hospital
INTRAOPERATIVE MITOMYCIN C AND 5 FLUOROURACILAPPLICATION DURING PRIMARY TRABECULECTOMY : A COMPARATIVE STUDY
Authors: Prasad Singh Gopal , Singh Urvashi , Jha Alka
Published: April 2021

Aim: To compare the outcome variables of these 2 commonly used anti-metabolites 5-Fluorouracil and Mitomycin-C in trabeculectomy surgeries
in primary glaucoma.
Material & methods: The present study was conducted on 50 eyes of 39 patients of primary glaucoma who underwent trabeculectomy over a
period from January 2019 to August 2020 at Darbhanga Medical College & Hospital, Laheriasarai, Darbhanga.The patients were randomly
categorized into 2 groups of 25 each. One group received 5-Fluorouracil in the dose of 50 mg/ml for duration of 4 to 5 minutes intraoperatively. The
other group received intraoperative Mitomycin-C in the dose of 0.4 mg/ml applied over duration of 2 to 3 minutes.
Result:Maximum complications were seen during early postoperative period in which maximum number were seen with POAG (9 cases)
followed by PACG (5 cases). Late postoperative complications were seen in POAG and PACG (2 in each).
Conclusion:Long-term complications may only become apparent many years later. Since our study had average period follow up of about 42
weeks, we are not able to comment on the long-term complications following the use of these drugs. In this study both 5-Fluorouracil and
Mitomycin-C were found to be equally safe.
CLINICALAND RADIOLOGICAL PATTERNS OF JOINT INVOLVEMENT IN JUVENILE INFLAMMATORY ARTHRITIS IN A TERTIARY CARE CENTER IN NORTH INDIA
Authors: Raghav Lokesh , Sinha Siddhartha , Gupta Sumit , Mahato Deonath , Kanojia Rajesh K
Published: April 2021

Introduction:Juvenile inammaory arthritis (JRA) is a common rheumatic disease of unknown etiology. There are few studies which objectively
measure regional patterns of disease activity and effects on functionality. Methods: This observational study of 35 children with JRA was
conducted in a university tertiary care center with paediatric rheumatology specialty. Clinical and radiological parameters using 27 joint Juvenile
Arthritis Disease Activity Score (JADAS) and Child Health Assessment Questionnaire (CHAQ) questionnaire for assessing disease activity,
radiological ndings and quality of life in over a period of 18 months. Results: Males were more commonly affected than females, with
appendicular skeleton involvement more common. Oligoarticular subtype was most common. Knee joint was most commonly affected. Grade 1
pain, swelling, tenderness was most common clinical nding among all the subgroups. In early course of disease osteopenia and subchondral
collapse were common radiological nding. Joint destruction was more common in radiographs of children with longer duration of disease.
JADAS score was maximum on Polyarthritis Rheumatoid Factor Positive (PolyRF +ve) patients and CHAQ score for Systemic Onset Juvenile
Inammatory Arthritis (SoJIA) subgroup with equal score in all subtypes for discomfort. Good correlation was found between JADAS and CHAQ
score for all JRAsubtypes except Enthesistis Related Arthritis (ERA) subtype.
A CORRELATION OF CLINICOPATHOLOGICAL AND RADIOLOGICAL FINDINGS OF CENTRAL NERVES SYSTEM TUMOURS
Authors: hemin Shroff Monika , Rajawat Abhishek , choudhary Kavita , w. Mukhiya Geeta
Published: April 2021

The annual incidence of tumors of the central nervous system ranges
from 10 to 17 per 100,000 persons for intracranial tumors and 1 to 2 per
100,000 persons for intraspinal tumors. Tumors of the CNS account for
nearly 20% of all cancers of childhood. Seventy percent of childhood
CNS tumors arise in the posterior fossa; a comparable number of
tumors in adults arise within the cerebral hemispheres above the tentorium
THE FUTURE OF THE DEMOCRATIC REPUBLIC OF THE CONGO(DRC) WITHOUT ITS MINERAL RESOURCES: WOOD AS A CIVIL ENGINEERING MATERIAL FOR THE DEVELOPMENT OF THIS COUNTRY
Authors: Mpanga Blaise Ngoie
Published: April 2021

The realization of civil engineering works always produces impacts on the economic and social development of a given region. Some of these
impacts can be positive and others negative. In the majority of cases, the options that exist, in relation to the design and project of these works, make
it possible to establish a link between the realization of these works, and the materials used for these works while preserving the environment. To
illustrate that it is possible to link the development of a region with civil engineering works, this article uses a few examples of materials used in the
realization of these works, including wood, which is a natural renewable source that we nd in vast areas in most provinces of the Democratic
Republic of Congo being poorly exploited, an optimal management of these woods can effectively contribute to the development of this large
country and consequently of Central Africa.
Towards Machine Learning-based Anomaly Detection on Time-Series Data
Authors: Vajda Daniel , Pekar Adrian , Farkas Karoly
Published: April 2021

The complexity of network infrastructures is exponentially growing. Real-time monitoring of these infrastructures is essential to secure their reliable operation. The concept of telemetry has been introduced in recent years to foster this process by streaming time-series data that contain feature-rich information concerning the state of network components. In this paper, we focus on a particular application of telemetry — anomaly detection on time-series data. We rigorously examined state-of-the-art anomaly detection methods. Upon close inspection of the methods, we observed that none of them suits our requirements as they typically face several limitations when applied on time-series data. This paper presents Alter-Re2, an improved version of ReRe, a state-of-the-art Long Short- Term Memory-based machine learning algorithm. Throughout a systematic examination, we demonstrate that by introducing the concepts of ageing and sliding window, the major limitations of ReRe can be overcome. We assessed the efficacy of Alter-Re2 using ten different datasets and achieved promising results. Alter-Re2 performs three times better on average when compared to ReRe.