bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolic and transcriptomic profiling during wheat seed development under progressive drought conditions
Authors: Mega Ryosuke , Kim June-Sik , Tanaka Hiroyuki , Ishii Takayoshi , Abe Fumitaka , Okamoto Masanori
Published: September 2023

Globally, bread wheat (Triticum aestivum) is one of the most important staple foods; when exposed to drought, wheat yields decline. Although much research has been performed to generate higher yield wheat cultivars, there have been few studies on improving end-product quality under drought stress, even though wheat is processed into flour to produce so many foods, such as bread, noodles, pancakes, cakes, and cookies. Recently, wheat cultivation has been affected by severe drought caused by global climate change. In previous studies, seed shrinkage was observed in wheat exposed to continuous drought stress during seed development. In this study, we investigated how progressive drought stress affected seed development by metabolomic and transcriptomic analyses. Metabolite profiling revealed the drought-sensitive line reduced accumulation of proline and sugar compared with the water-saving, drought-tolerant transgenic line overexpressing the abscisic acid receptor TaPYL4 under drought conditions in spikelets with developing seeds. Meanwhile, the expressions of genes involved in translation, starch biosynthesis, and proline and arginine biosynthesis was downregulated in the drought-sensitive line. These findings suggest that seed shrinkage, exemplifying a deficiency in endosperm, arose from the hindered biosynthesis of crucial components including seed storage proteins, starch, amino acids, and sugars, ultimately leading to their inadequate accumulation within spikelets. Water-saving drought tolerant traits of wheat would aid in supporting seed formation under drought conditions.
Spatial perspective and identity in visual awareness of the bodily self-other distinction
Authors: Ciorli Tommaso , Pia Lorenzo
Published: September 2023

Spatial perspective and identity of visual bodily stimuli are two key cues for the self-other distinction. However, how they emerge into visual awareness is largely unknown. Here, self- or other-hands presented in first- or third-person perspective were compared in a breaking-Continuous Flash Suppression paradigm (Experiment 1) measuring the time the stimuli need to access visual awareness, and in a Binocular Rivalry paradigm (Experiment 2), measuring predominance in perceptual awareness. Results showed that, irrespectively of identity, first-person perspective speeded up the access, whereas the third-person one increased the dominance. We suggest that the effect of first-person perspective represents an unconscious prioritization of an egocentric body coding important for visuomotor control. On the other hand, the effect of third-person perspective indicates a conscious advantage of an allocentric body representation fundamental for detecting the presence of another intentional agent. Summarizing, the emergence of self-other distinction into visual awareness would strongly depend on the interplay between spatial perspectives, with an inverse prioritization before and after conscious perception. On the other hand, identity features might rely on post-perceptual processes.
EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer
Authors: Wang Yuan , Liu Yang , Wang Cong , Kang Rui , Tang Daolin , Liu Jiao
Published: September 2023

Ferroptosis is a form of regulated cell death characterized by oxidative injury-induced lipid peroxidation. However, the detailed protein post-translational modification regulatory mechanism of ferroptosis remains largely unknown. Here, we report that E1A binding protein P300 (EP300) acetyltransferase promotes ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells via the acetylation of heat shock protein family A (Hsp70) member 5 (HSPA5), also known as GRP78 or BIP) on the site of K353. Acetylated HSPA5 loses its ability to inhibit lipid peroxidation and subsequent ferroptotic cell death. Genetic or pharmacological inhibition of EP300-mediated HSPA5 acetylation on K353 increases PDAC cell resistance to ferroptosis. Moreover, histone deacetylase 6 (HDAC6) limits HSPA5 acetylation and subsequent ferroptosis. Collectively, these findings not only identify regulatory pathways for HSPA5 acetylation during ferroptosis, but also highlight promising strategies to increase ferroptosis sensitivity in PDAC cells.
A thioacetamide-induced liver fibrosis model for pre-clinical studies in microminipig
Authors: Nishi Kotaro , Yagi Hiroshi , Ohtomo Mana , Nagata Shogo , Udagawa Daisuke , Tsuchida Tomonori , Morisaku Toshinori , Kitagawa Yuko
Published: September 2023

Drug-induced liver fibrosis models are used in normal and immunosuppressed small animals for transplantation and regenerative medicine to improve liver fibrosis. Although large animal models are needed for pre-clinical studies, they are yet to be established owing to drug sensitivity in animal species and difficulty in setting doses. In this study, we evaluated liver fibrosis by administering thioacetamide (TA) to normal microminipig and thymectomized microminipig; 3 times for 1 week (total duration: 8 weeks). The pigs treated with TA showed elevated blood cytokine levels and a continuous liver injury at 8 weeks. RNA-seq of the liver showed increased expression of fibrosis-related genes after TA treatment. Histopathological examination showed degenerative necrosis of hepatocytes around the central vein, and revealed fibrogenesis and hepatocyte proliferation. TA treatment caused CD3-positive T cells and macrophages scattered within the hepatic lobule to congregate near the center of the lobule and increased αSMA-positive cells. Thymectomized pigs showed liver fibrosis similar to that of normal pigs, although the clinical signs tended to be milder. This model is similar to pathogenesis of liver fibrosis reported in other animal models. Therefore, it is expected to contribute to research as a drug discovery and pre-clinical transplantation models.
Experimental studies of the influence of mobile fan positioning parameters on the ability to transport the air stream into the door opening
Authors: Kaczmarzyk Piotr , Warguła Łukasz , Janik Paweł
Published: September 2023

The article aims to determine the influence of fan positioning parameters, i.e., its distance from a door opening (1–7 m) and the angle of inclination of the impeller axis in relation to the ground (0°–18°) on the amount of air flow pumped through a door opening. The experiment was carried out using a mock-up simulating a door opening, on which a measurement plane was located, without the cubic capacity (building structure) behind the door opening. The volumetric air flow stream was determined based on measuring (at 50 measuring points) the velocity of the air stream blown onto the surface of the door opening mock-up. Four commercial positive pressure ventilators, commonly used in rescue operations, with a power of 0.6–6.3 kW were tested. The tests showed that the value of the air flow stream at the most favourable setting (distance in the range of 3–5 m and the angle of the impeller axis to the ground in the range of 5°–12.2°) is included in the range of 18,304 ± 2460 m3/h to about 45,189 ± 4619 m3/h. Such settings cause the air stream to be aimed at the central area of the door opening. Imprecise mobile fan arrangement may reduce the flow rate from 41 to 76% in relation to the most favourable results.
Risk analysis of fluctuating hypercalcemia after leukapheresis in cellular therapy
Authors: Jo Tomoyasu , Arai Yasuyuki , Kitawaki Toshio , Nishikori Momoko , Mizumoto Chisaki , Kanda Junya , Yamashita Kouhei , Nagao Miki , Takaori-Kondo Akifumi
Published: September 2023

Optimized management of citrate-induced hypocalcemia is required to provide safe leukapheresis. We prospectively analyzed subjects who underwent leukapheresis for cytotherapy, and evaluated serum ionized (iCa) concentrations before, at the end of, and 1 h after leukapheresis. During leukapheresis, calcium gluconate solution was continuously supplemented intravenously with hourly measurement of iCa. 76 patients including 49 lymphapheresis for chimeric antigen receptor T-cell therapy and 27 stem cell collections were enrolled. Median processing blood volume was 10 L (range, 6–15 L). Fluctuating hypercalcemia, in which the iCa concentration rose above its upper limit 1 h after leukapheresis, was observed in 58 subjects (76.3%). Multivariate analysis revealed that higher ratios of processing blood volume to body weight, more rapid calcium supplementation, and lower iCa concentration at the end of leukapheresis significantly increased elevation of serum iCa concentration by 1 h after leukapheresis. Based on multivariate analyses, we developed a formula and a diagram that accurately estimates serum iCa concentration 1 h post-leukapheresis. This suggests optimal targets for iCa concentration and calcium supplementation rates. In cases with high ratios of processing blood volume to body weight, slowing the rate of blood processing, rather than increasing calcium supplementation should safely alleviate hypocalcemia during leukapheresis without inducing hypercalcemia thereafter.
A novel reconstruction method combining multi-detector SPECT with an elliptical orbit and computer tomography for cardiac imaging
Authors: Sheng Jinhua , Huang Pu , Zhou Rougang , Li Zhongjin , Yang Xiaofan , Wang Jialei
Published: September 2023

The myocardial single photon emission computed tomography (SPECT) is a good study due to its clinical significance in the diagnosis of myocardial disease and the requirement for improving image quality. However, SPECT imaging faces challenges related to low spatial resolution and significant statistical noise, which concerns patient radiation safety. In this paper, a novel reconstruction system combining multi-detector elliptical SPECT (ME-SPECT) and computer tomography (CT) is proposed to enhance spatial resolution and sensitivity. The hybrid imaging system utilizes a slit-slat collimator and elliptical orbit to improve sensitivity and signal-to-noise ratio (SNR), obtains accurate attenuation mapping matrices, and requires prior information from integrated CT. Collimator parameters are corrected based on CT reconstruction results. The SPECT imaging system employs an iterative reconstruction algorithm that utilizes prior knowledge. An iterative reconstruction algorithm based on prior knowledge is applied to the SPECT imaging system, and a method for prioritizing the reconstruction of regions of interest (ROI) is introduced to deal with severely truncated data from ME-SPECT. Simulation results show that the proposed method can significantly improve the system's spatial resolution, SNR, and image fidelity. The proposed method can effectively suppress distortion and artifacts with the higher spatial resolution ordered subsets expectation maximization (OSEM); slit-slat collimation.
Adapting physiologically-based pharmacokinetic models for machine learning applications
Authors: Habiballah Sohaib , Reisfeld Brad
Published: September 2023

Both machine learning and physiologically-based pharmacokinetic models are becoming essential components of the drug development process. Integrating the predictive capabilities of physiologically-based pharmacokinetic (PBPK) models within machine learning (ML) pipelines could offer significant benefits in improving the accuracy and scope of drug screening and evaluation procedures. Here, we describe the development and testing of a self-contained machine learning module capable of faithfully recapitulating summary pharmacokinetic (PK) parameters produced by a full PBPK model, given a set of input drug-specific and regimen-specific information. Because of its widespread use in characterizing the disposition of orally administered drugs, the PBPK model chosen to demonstrate the methodology was an open-source implementation of a state-of-the-art compartmental and transit model called . The model was tested for drug formulations spanning a large range of solubility and absorption characteristics, and was evaluated for concordance against predictions of and relevant experimental data. In general, the values predicted by the ML models were within 20% of those of the PBPK model across the range of drug and formulation properties. However, summary PK parameter predictions from both the ML model and full PBPK model were occasionally poor with respect to those derived from experiments, suggesting deficiencies in the underlying PBPK model.
Morphological and physiological adaptations of psychrophilic Pseudarthrobacter psychrotolerans YJ56 under temperature stress
Authors: Son Yongjun , Min Jihyeon , Shin Yoonjae , Park Woojun
Published: September 2023

Both culture-independent and culture-dependent analyses using Nanopore-based 16S rRNA sequencing showed that short-term exposure of Antarctic soils to low temperature increased biomass with lower bacterial diversity and maintained high numbers of the phylum Proteobacteria, Firmicute, and Actinobacteria including Pseudarthrobacter species. The psychrophilic Pseudarthrobacter psychrotolerans YJ56 had superior growth at 13 °C, but could not grow at 30 °C, compared to other bacteria isolated from the same Antarctic soil. Unlike a single rod-shaped cell at 13 °C, strain YJ56 at 25 °C was morphologically shifted into a filamentous bacterium with several branches. Comparative genomics of strain YJ56 with other genera in the phylum Actinobacteria indicate remarkable copy numbers of rimJ genes that are possibly involved in dual functions, acetylation of ribosomal proteins, and stabilization of ribosomes by direct binding. Our proteomic data suggested that Actinobacteria cells experienced physiological stresses at 25 °C, showing the upregulation of chaperone proteins, GroEL and catalase, KatE. Level of proteins involved in the assembly of 50S ribosomal proteins and L29 in 50S ribosomal proteins increased at 13 °C, which suggested distinct roles of many ribosomal proteins under different conditions. Taken together, our data highlights the cellular filamentation and protein homeostasis of a psychrophilic YJ56 strain in coping with high-temperature stress.
Frictional resistance calculation and jacking force prediction of rectangular pipe jacking
Authors: Kong Chao , Guan Guoqing , Gu Song , Zhou Zaiyan , Wang Haiyan
Published: September 2023

In practical engineering, whilst estimating the jacking force of rectangular pipe jacking using an empirical formula, the results obtained from said formula deviate from reality and manifest inadequate engineering guidance. The equations governing the applied force during the installation of rectangular pipe jacking have been derived for various contact states involving the interaction between the pipe, slurry, and soil. The distinct stress conditions in the pipe jacking process as well as the shear-friction mechanism between the pipe and the surrounding soil have been taken into account. The displacement control method is introduced to simulate the pipe–slurry–soil contact friction during the pipe jacking process in FLAC3D. Additionally, the pipe jacking behavior, pipe–slurry–soil contact frictional force, and variation law of the jacking force are also simulated. Mutual verification was carried out using the results obtained from field monitoring, numerical and theoretical. The findings are as follows: the established equations for calculating pipe jacking force are highly applicable across various conditions of pipe–slurry–soil contact, and the outcomes derived from theoretical formulas align remarkably well with those obtained through field monitoring and numerical simulation. During the jacking process, the sidewalls exhibit initial partial sliding followed by a complete movement as the jacking force intensifies and subsequently diminishes, eventually attaining stability during the behavior adjustment phase. Moreover, the bottom pipe–soil contact is the most common situation in actual construction.
Sugarcane nitrogen nutrition estimation with digital images and machine learning methods
Authors: You Hui , Zhou Muchen , Zhang Junxiang , Peng Wei , Sun Cuimin
Published: September 2023

The color and texture characteristics of crops can reflect their nitrogen (N) nutrient status and help optimize N fertilizer management. This study conducted a one-year field experiment to collect sugarcane leaf images at tillering and elongation stages using a commercial digital camera and extract leaf image color feature (CF) and texture feature (TF) parameters using digital image processing techniques. By analyzing the correlation between leaf N content and feature parameters, feature dimensionality reduction was performed using principal component analysis (PCA), and three regression methods (multiple linear regression; MLR, random forest regression; RF, stacking fusion model; SFM) were used to construct N content estimation models based on different image feature parameters. All models were built using five-fold cross-validation and grid search to verify the model performance and stability. The results showed that the models based on color-texture integrated principal component features (C-T-PCA) outperformed the single-feature models based on CF or TF. Among them, SFM had the highest accuracy for the validation dataset with the model coefficient of determination (R2) of 0.9264 for the tillering stage and 0.9111 for the elongation stage, with the maximum improvement of 9.85% and 8.91%, respectively, compared with the other tested models. In conclusion, the SFM framework based on C-T-PCA combines the advantages of multiple models to enhance the model performance while enhancing the anti-interference and generalization capabilities. Combining digital image processing techniques and machine learning facilitates fast and nondestructive estimation of crop N-substance nutrition.
New insights into the poleward migration of tropical cyclones and its association with Hadley circulation
Authors: Anjana U. , Kumar Karanam Kishore
Published: September 2023

Recent investigations have shown a robust signature of poleward migration of the tropical cyclone latitudes using observations and climate model simulations. Most of these studies invoked the role of the Hadley circulation (HC) expansion in the poleward shifting of tropical cyclones. However, none of these studies focused on the dissection of the zonally asymmetric HC into ascending and descending regions at regional scales, which holds the key in establishing the association between these two phenomena. Here, we are reporting the poleward migration of tropical cyclones and their association with ascending region boundaries of the HC at regional scales for the first time. The results emphatically show that the tropical cyclone latitudes as well as latitudes of maximum lifetime intensity vary in tandem with boundaries of the ascending region of the HC as compared to its descending region thus providing a vital clue on processes governing poleward migration of tropical cyclones.
Linking spontaneous and stimulated spine dynamics
Authors: Eggl Maximilian F. , Chater Thomas E. , Petkovic Janko , Goda Yukiko , Tchumatchenko Tatjana
Published: September 2023

Our brains continuously acquire and store memories through synaptic plasticity. However, spontaneous synaptic changes can also occur and pose a challenge for maintaining stable memories. Despite fluctuations in synapse size, recent studies have shown that key population-level synaptic properties remain stable over time. This raises the question of how local synaptic plasticity affects the global population-level synaptic size distribution and whether individual synapses undergoing plasticity escape the stable distribution to encode specific memories. To address this question, we (i) studied spontaneously evolving spines and (ii) induced synaptic potentiation at selected sites while observing the spine distribution pre- and post-stimulation. We designed a stochastic model to describe how the current size of a synapse affects its future size under baseline and stimulation conditions and how these local effects give rise to population-level synaptic shifts. Our study offers insights into how seemingly spontaneous synaptic fluctuations and local plasticity both contribute to population-level synaptic dynamics.
An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate
Authors: Perez-Garcia Pablo , Chow Jennifer , Costanzi Elisa , Gurschke Marno , Dittrich Jonas , Dierkes Robert F. , Molitor Rebecka , Applegate Violetta , Feuerriegel Golo , Tete Prince , Danso Dominik , Thies Stephan , Schumacher Julia , Pfleger Christopher , Jaeger Karl-Erich , Gohlke Holger , Smits Sander H. J. , Schmitz Ruth A. , Streit Wolfgang R.
Published: September 2023

Polyethylene terephthalate (PET) is a commodity polymer known to globally contaminate marine and terrestrial environments. Today, around 80 bacterial and fungal PET-active enzymes (PETases) are known, originating from four bacterial and two fungal phyla. In contrast, no archaeal enzyme had been identified to degrade PET. Here we report on the structural and biochemical characterization of PET46 (RLI42440.1), an archaeal promiscuous feruloyl esterase exhibiting degradation activity on semi-crystalline PET powder comparable to IsPETase and LCC (wildtypes), and higher activity on bis-, and mono-(2-hydroxyethyl) terephthalate (BHET and MHET). The enzyme, found by a sequence-based metagenome search, is derived from a non-cultivated, deep-sea Candidatus Bathyarchaeota archaeon. Biochemical characterization demonstrated that PET46 is a promiscuous, heat-adapted hydrolase. Its crystal structure was solved at a resolution of 1.71 Å. It shares the core alpha/beta-hydrolase fold with bacterial PETases, but contains a unique lid common in feruloyl esterases, which is involved in substrate binding. Thus, our study widens the currently known diversity of PET-hydrolyzing enzymes, by demonstrating PET depolymerization by a plant cell wall-degrading esterase.
Superhydrophobic Coatings on Metallic Substrates I: Magnesium Based
Authors: Wang Yaming , Wang Shuqi
Published: September 2023

Superhydrophobic coatings can not only improve the corrosion resistance of Mg and Mg alloys, but also endow them with many surface functions. However, the vulnerability of the delicate surface textures significantly impedes the practical application of superhydrophobic surfaces. This chapter first introduces robust superhydrophobicity design strategies, including passive resistance and active regeneration strategies, then various approaches for developing superhydrophobic coatings on Mg and Mg alloys and durability issues are highlighted. Finally, the challenges to improving the durability of superhydrophobic coatings on Mg and Mg alloys and future development prospects are summarized.
Prediction of type 1 diabetes with machine learning algorithms based on FTIR spectral data in peripheral blood mononuclear cells
Authors: Rostoka Evita , Shvirksts Karlis , Salna Edgars , Trapina Ilva , Fedulovs Aleksejs , Grube Mara , Sokolovska Jelizaveta
Published: September 2023

A promising trend has been found to predict the presence of type 1 diabetes using PBMC metabolic fingerprinting and machine learning. This will enable extensive monitoring of public health, timely diagnosis of diseases and initiation of treatment.
Nitrocellulose membranes in situ grown with Prussian blue nanoparticles as stable nanozyme pads for colorimetric detection of dopamine
Authors: Zhang Shuting , Li Cuili , Sun Zhihong , Liu Jie , Fu Guanglei
Published: September 2023

Nitrocellulose (NC) membranes were exploited as synthesis hosts of Prussian blue nanoparticles (PB NPs) to develop a new type of 3D porous peroxidase-mimicking nanozyme pad for colorimetric detection of dopamine (DA) in urine.
A disposable and sensitive sensor based on a ZIF-8@graphene modified carbon paper electrode for the quantitative determination of luteolin
Authors: Pang Wanyu , Gao Yali , Hu Tuoping , Ma Xuemei
Published: September 2023

Strategy of fabricating a ZIF-8@GR/CP electrode by an in situ growth method.
Speciation of trace amounts of Sb(iii) and Sb(v) in environmental water using inductively coupled plasma mass spectrometry after magnetic solid-phase extraction with rGO/Fe3O4
Authors: Wang Qiang , Nie Yulin , Wu Zhibin , Yang Yuan
Published: September 2023

We developed an approach of magnetic dispersive solid-phase extraction (MSPE) based on magnetic graphene nanocomposite rGO/Fe3O4 for the determination of trace Sb(iii) and Sb(v) using inductively coupled plasma mass spectrometry (ICP-MS).
A novel “on–off–on” near-infrared fluorescent probe for Cu2+ and S2− continuous detection based on dicyanoisoflurone derivatives, and its application in bacterial imaging
Authors: Yao Yixuan , Zeng Fudong , Wu Liangqiang , Xing Shuo , Yang Qingbiao , Li Yaoxian
Published: September 2023

We have successfully synthesized a near-infrared fluorescent probe that can continuously detect Cu2+ and S2−. Probe DL can be used for fluorescence imaging experiments of Staphylococcus aureus.
Online chemiluminescence determination of the hydroxyl radical using coumarin as a probe
Authors: Geng Pengyu , Lv Jitao , Zhao Lixia , Wang Yawei
Published: September 2023

A novel method for online detection of ˙OH by flow oxidization chemiluminescence using coumarin as a probe was established.
Recent advances in the application and biological mechanism of silicon nitride osteogenic properties: a review
Authors: Liu Ziyi , Wang Ruijie , Liu Wenjing , Liu Yushan , Feng Xiaoli , Zhao Fujian , Chen Pei , Shao Longquan , Rong Mingdeng
Published: September 2023

Mechanism of silicon nitride promoting osteogenesis and related applications of its excellent osteogenic properties.
A two-dimensional VO2/VS2 heterostructure as a promising cathode material for rechargeable Mg batteries: a first principles study
Authors: Luo§ Lingxiao , Tan Shuangshuang , Gao Zhipeng , Yang Xiaofang , Xu Junyao , Huang Guangsheng , Wang Jingfeng , Pan Fusheng
Published: September 2023

A strategy that partially replaces S atoms with O atoms in layered VS2 to form a heterostructure material effectively enhances the electron conductivity, average discharge platform and theoretical capacity.
Role of inorganic layers on polysulfide decomposition at sodium-metal anode surfaces for room temperature Na/S batteries
Authors: Singsen Sirisak , Ospina-Acevedo Francisco , Suthirakun Suwit , Hirunsit Pussana , Balbuena Perla B.
Published: September 2023

Distinct passivation behavior was observed in thin SEI films of NaOH, Na2O, and Na2CO3 over Na metal surfaces attributed to the films’ electronic and structural properties and evolution; tested with a simulated molecular decomposition over the SEI.
Aggregation behaviour of pyrene-based luminescent materials, from molecular design and optical properties to application
Authors: Feng Xing , Wang Xiaohui , Redshaw Carl , Tang Ben Zhong
Published: September 2023

This review not only highlights the progress of the emission and electronic behaviour of new pyrene-based luminescence molecules in the aggregated state, but also provides a new perspective for understanding the luminescence mechanism and optoelectronic properties of pyrenes.
Waste tailing particle electrode enables enhanced electrochemical degradation of sulfamethoxazole
Authors: Bu Jiaqi , Jiang Hongru , Li Tianhao , Zhou Chengyun , Zhong Shian
Published: September 2023

In the electrocatalytic (EC) degradation process, low current efficiency, mineralization efficiency, and mass transfer efficiency have limited its widespread application.
DNA delivery by high aspect ratio nanomaterials to algal chloroplasts
Authors: Newkirk Gregory M. , Jeon Su-Ji , Kim Hye-In , Sivaraj Supreetha , De Allende Pedro , Castillo Christopher , Jinkerson Robert E. , Giraldo Juan Pablo
Published: September 2023

Single walled carbon nanotubes (SWCNTs) are coated with polyethylenimine (PEI) of different molecular weight for DNA delivery into algal chloroplasts without the use of mechanical aid for understanding their impact on cell viability and function.
Ginsenosides: a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease
Authors: Wang Lina , Zhang Yanxin , Song Zhimin , Liu Qingchao , Fan Daidi , Song Xiaoping
Published: September 2023

A summary of the mechanisms of various ginsenosides in the treatment of lung cancer and pulmonary inflammatory diseases.
Iridoid- and flavonoid-enriched fractions ofCornus sanguineaandCornus masexert antioxidant and anti-inflammatory effects and inhibit key enzymes in the treatment of metabolic disorders
Authors: Tenuta Maria Concetta , Loizzo Monica Rosa , Tundis Rosa , Dugay Annabelle , Bouzidi Chouaha , Marie Arul , Acquaviva Rosaria , Cappello Anna Rita , Deguin Brigitte
Published: September 2023

Berry fruits are recognized as a “superfood” due to their high content of bioactive compounds and health benefits.
Planar carbenium ions for robust symmetrical all organic redox flow batteries
Authors: Moutet Jules , Nowack Marko H. , Mills David D. , Lozier Diego L. , Laursen Bo W. , Gianetti Thomas L.
Published: September 2023

Development of a bipolar redox active material for symmetrical full organic flow batteries (NAORFB) will enhance their stability and growth.
SANS contrast matching for the unambiguous localization of anionic dye in cationic surfactant micelles
Authors: Müller Wenke , Schweins Ralf , Nöcker Bernd , Egold Hans , Hannappel Yvonne , Huber Klaus
Published: September 2023

The complementary use of SANS contrast matching and NMR-spectroscopy permits the unambiguous localization of an anionic dye in dodecyl trimethyl-ammonium bromide micelles.
Facile synthesis of PbBiO2X/Ti3C2 MXene composites with efficient visible photocatalytic activity
Authors: Yu Yanlong , Zhang Jun , Shi Zhaojun , Li Ziying , Yan Sai
Published: September 2023

Three series of novel PbBiO2X/Ti3C2 composited photocatalysts were synthesized for the first time.
Transition from monolayer-thick 2D to 3D nano-clusters on α-Al2O3(0001)
Authors: Lazzari Rémi , Goniakowski Jacek , Cabailh Gregory , Cavallotti Rémi , Jupille Jacques , Trcera Nicolas , Lagarde Pierre
Published: September 2023

This paper reports on the long-standing puzzle of the atomic structure of the Ag/α-Al2O3(0001) interface by combining X-ray absorption spectroscopy, to determine Ag local environment, and numerical simulations on nanometric-sized particles.
Opposite luminescence thermal behavior of upconversion core/shell nanocrystals for anticounterfeiting
Authors: Hu Yanqing , Yu Shijie , Deng Xinyi , Zhou Jiaqiang , Zhang Rui , Shao Qiyue
Published: September 2023

Based on an opposite luminescence thermal behavior between active- and inert-shell nanocrystals, their hybrids with thermal-responsive multicolor emissions are developed for anticounterfeiting applications.
Cross-linking electrospinning
Authors: Han Wei-Hua , Wang Qing-Yu , Kang Yuan-Yi , Shi Li-Rui , Long Yu , Zhou Xin , Hao Chun-Cheng
Published: September 2023

The cross-linking electrospinning system, including three electrospinning strategies, four cross-linking strategies, two major cross-linking mechanisms, and six representative applications, was addressed for the first time.
High-valence Ni3+ construction and stability by electrochemical de-lithiation boosting oxygen evolution
Authors: Li Shujing , Zhu Xiaoming , Wang Xiaohan , Luo Wenshu , Yu Xu , Guo Qiuyun , Song Kunming , Tian Han , Cui Xiangzhi , Shi Jianlin
Published: September 2023

High-valence Ni3+ and O vacancies generated during electrochemical de-lithiation endow the cathode NCM of spent lithium-ion batteries with high OER performance.
Supramolecular Cu(ii) nanoparticles supported on a functionalized chitosan containing urea and thiourea bridges as a recoverable nanocatalyst for efficient synthesis of 1H-tetrazoles
Authors: Bondarian Shirin , Dekamin Mohammad G. , Valiey Ehsan , Naimi-Jamal M. Reza
Published: September 2023

Newly synthesized supported Cu(ii) nanoparticles were designed. The obtained supramolecular nanocomposite promotes multicomponent cascade Knoevenagel condensation/click 1,3-dipolar cycloaddition for synthesis of (E)-2-(1H-tetrazole-5-yl)-3-arylacrylenenitrile derivatives.
The construction of a biomass component interaction model based on research into the hydrothermal liquefaction of sewage sludge
Authors: Zhao Lei , Xie Longfei , Gou Le , Dai Liyi , Wang Yuanyuan
Published: September 2023

Probing the reaction mechanism of sludge hydrothermal liquefaction through the reaction of model compounds.
Temporal logic circuits implementation using a dual cross-inhibition mechanism based on DNA strand displacement
Authors: Liu Yuan , Zhang Xiaokang , Zhang Xun , Liu Xin , Wang Bin , Zhang Qiang , Wei Xiaopeng
Published: September 2023

Temporal logic circuit implementation using a dual inhibition mechanism based on DNA strand displacement and optimization through incorporating an annihilation mechanism.
Physical properties of the low-cost CZTS absorber layer deposited by spin-coating: effect of the copper concentration associated with SCAPS-1D simulation
Authors: Zakaria Sana , El mahboub Elyazid , EL Hichou Ahmed
Published: September 2023

The results obtained in this study support the use of spin-coated CZTS films as absorber layers in thin film solar cells and the use of only 1.5 M copper concentration to achieve an efficient absorber layer.
Facile synthesis of Ag/ZIF-8@ZIF-67 as an electrochemical sensing platform for sensitive detection of halonitrophenols in drinking water
Authors: Xiao Jiaxin , Zhu Shumin , Bu Lingjun , Chen Yuan , Wu Ruoxi , Zhou Shiqing
Published: September 2023

A core–shell metal–organic framework (MOF) based electrochemical sensor (Ag/ZIF-8@ZIF-67) capable of detecting 2,6-DCNP is prepared, with a broad linear response range (R2 = 0.992) from 240 nM to 288 μM and a low detection limit of 20 nM.
Insights into the evolution of chemical structure and pyrolysis reactivity of PVC-derived hydrochar during hydrothermal carbonization
Authors: Zhang Ling , Wang Qing , Xu Faxing , Wang Zhenye
Published: September 2023

This article investigates the impact of hydrothermal temperature on two PVC structures and the thermal degradation of hydrothermal carbon. It aims to establish a quantitative link between hydrothermal carbon structure and reactivity.
Palladium-catalyzed intramolecular aza-Wacker-type cyclization of vinyl cyclopropanecarboxamides to access conformationally restricted aza[3.1.0]bicycles
Authors: Li Mengjuan , Li Jingya , Zhang Zhiguo , Chen Liming , Ma Nana , Liu Qingfeng , Zhang Xingjie , Zhang Guisheng
Published: September 2023

A palladium(ii)-catalyzed intramolecular oxidative aza-Wacker-type reaction of vinyl cyclopropanecarboxamides to access a series of conformationally restricted highly substituted aza[3.1.0]bicycles is reported.
Exploring the anti-obesity bioactive compounds of Thymelaea hirsuta and Ziziphus spina-christi through integration of lipase inhibition screening and molecular docking analysis
Authors: Abdallah Rokia M. , Hammoda Hala M. , El-Gazzar Nahla S. , Ibrahim Reham S. , Sallam Shaimaa M.
Published: September 2023

Activity-guided fractionation of the ethanolic extracts of Thymelaea hirsuta and Ziziphus spina-christi furnished eight compounds with pancreatic lipase inhibitory activity.
Electron count and ligand composition influence the optical and chiroptical signatures of far-red and NIR-emissive DNA-stabilized silver nanoclusters
Authors: Guha Rweetuparna , Gonzàlez-Rosell Anna , Rafik Malak , Arevalos Nery , Katz Benjamin B. , Copp Stacy M.
Published: September 2023

AgN-DNAs emitters at the far red/NIR spectral border have either 6 or 8 valence electrons and at least three distinct ligand compositions. Stokes shift magnitude and CD signatures are correlated with ligand composition.
–SR removal or –R removal? A mechanistic revisit on the puzzle of ligand etching of Au25(SR)18 nanoclusters during electrocatalysis
Authors: Sun Fang , Qin Lubing , Tang Zhenghua , Deng Guocheng , Bootharaju Megalamane S. , Wei Zidong , Tang Qing , Hyeon Taeghwan
Published: September 2023

The advanced constant-potential solvation dynamic calculations revealed that the preferential attack of protons on the S site is the key factor for the weakening and breaking of Au–S bonds, thereby facilitating the desorption of thiolate ligands.
Room temperature stable E,Z-diphosphenes: their isomerization, coordination, and cycloaddition chemistry
Authors: Lin Jieli , Liu Shihua , Zhang Jie , Grützmacher Hansjörg , Su Cheng-Yong , Li Zhongshu
Published: September 2023

N-Heterocyclic vinyl substituted diphosphenes 2b in both E- and Z-isomers have been isolated and crystallographically characterized. They exhibit reversible photo- and thermally stimulated E ↔ Z isomerization mimicking their carbon analogue.
Structural color from pigment-loaded nanostructures
Authors: Sai Tianqi , Froufe-Pérez Luis S. , Scheffold Frank , Wilts Bodo D. , Dufresne Eric R.
Published: September 2023

Pigment can efficiently create bright structural colors at wavelengths outside its absorption band.
Direct 3D print polyimide aerogels for synergy management of thermal insulation, gas permeability and light absorption
Authors: Yang Jianming , Lu Jialu , Xi Shuang , Wang Hongqiang , Han Dongxiao , Fan Caide , Zhang Zhihua , Shen Jun , Zhou Bin , Du Ai
Published: September 2023

Polyimide aerogels with synergy management of thermal insulation, gas permeability and light absorption are printed, and further expanding their applications in buildings, solar steam generation and solar seawater purification.
Holmium rare earth metal ion incorporated and ambient-air processed all-inorganic γ-CsPbI2.5Br0.5 perovskite solar cells yielding high efficiency and stable performance
Authors: Patil Jyoti V. , Mali Sawanta S. , Hong Chang Kook
Published: September 2023

Ambient-air processed highly efficient inorganic perovskite solar cells with holmium rare earth metal ion incorporated γ-CsPbI2.5Br0.5-based perovskite surpassing 19% power conversion efficiency with improved stability.
Tuning of cationic distribution in “partially inversed” cobalt ferrite spinel nanocubes via a nitrogen-doped graphene oxide support for enhanced bifunctional oxygen electrocatalysis
Authors: Jha Shwetambara , Jain Priya , Palkovits Regina , Popinand Ingole Pravin
Published: September 2023

A strategy to improve the bifunctional oxygen electrocatalytic activity of cobalt ferrite spinel (CoFe2O4) nanocubes by a N-doped graphene oxide (NGO) support induced redistribution of cations at octahedral versus tetrahedral sites is presented.
Stretchable and self-healing electronic skin based on a piezoelectric/triboelectric polyester elastomer for deep and superficial sensation
Authors: Qiao Yanxiu , Zhang Qian , Xiang Yong , Wang Zhao , Hu Xiaoran
Published: September 2023

A piezoelectric elastomer is fabricated as e-skin realizing synchronous sensing of superficial and deep sensations. The e-skin demonstrates human-skin-like properties including stretchability, self-healing capability, and biocompatibility.
All-in-one ultrathin nanoporous ZnIn2S4 with ameliorated photoredox capability: harvesting electron–hole pairs in cooperative hydrogen and benzaldehyde production
Authors: Sheng Ling Grayson Zhi , Wan Kok Steven Hao , Zhang Peipei , Siang Tan Ji , Haw Choon Yian , Tan Lling-Lling , Chen Binghui , Ong Wee-Jun
Published: September 2023

All-in-one ultrathin porous ZnIn2S4 toward photocatalytic water reduction and benzyl alcohol oxidation for the co-production of hydrogen fuels and value-added benzaldehyde.
Improvement of the Li metal-electrolyte interfacial stability by cis–trans polar conformer formation in a carbonate electrolyte
Authors: Lee Min A , Leem Han Jun , Lee Jeong Beom , Hwang Chihyun , Yu Jisang , Kim Hyun-seung
Published: September 2023

This work focuses on interfacial engineering by electrolyte modulation, that is, cis–trans polar conformer formation of dimethyl carbonate, as strategy to widen electrochemical stability window, thus improving cycleability of lithium-metal batteries.
Spectroscopic features of a perylenediimide probe for sensing amyloid fibrils: in vivo imaging of Aβ-aggregates in a Drosophila model organism
Authors: Barooah Nilotpal , Karmakar Puja , Sharanya M. K. , Mishra Monalisa , Bhasikuttan Achikanath C. , Mohanty Jyotirmayee
Published: September 2023

In vivo imaging and reduction of Aβ-aggregates in the brain/eye sections of living Drosophila organisms has been achieved by treating with a non-toxic perylenediimide derivative, a promising therapeutic for human brains with neurodegenerative diseases.
Magneto-assisted enzymatic DNA walkers for simultaneous electrochemical detection of amyloid-beta oligomers and Tau
Authors: Cheng Tao , Yuan Hongxiu , Dong Yixi , Xu Shuo , Wang Gang , Zhao Miaoqing , Jiao Jianwei , Jiao Jin
Published: September 2023

An electrochemical aptasensor for AβO and Tau simultaneously detection and used successfully identifies Alzheimer’s patients among real samples.
Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation
Authors: Fang Meng , Lin Liping , Zheng Muyue , Liu Wei , Lin Rongguang
Published: September 2023

Antimicrobial mechanisms of functionalized carbon dots: covalent and non-covalent interactions, reactive oxygen species, photothermal effect, and size effect (E. coli was used as a model).
Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs
Authors: Abánades Lázaro Isabel , Vicent-Morales María , Mínguez Espallargas Guillermo , Giménez-Marqués Mónica
Published: September 2023

NanoMUV-2 stores high payloads of Paclitaxel and increases its anticancer selectivity.
Synergistic enhancement of the optoelectronic performance and stability of MA and Cs in FAxMAyCs1−x−yPbIzBr3−z single crystals
Authors: Wang Kaiyu , Chen Feitong , Yao Qing , Zhang Jie , Zhu Huiling , Zhang Weiwei , Zhan Xiaoyuan , Wang Shenglai , Ding Jianxu
Published: September 2023

A-site cations, particularly MA, enhanced the stability and optoelectronic properties of FAxMAyCs1−x−yPbIzBr3−z single crystals.
Insights into luminescence thermal quenching of Mn4+-doped BaLa(Na/Li)(W/Te)O6 double perovskite red phosphors
Authors: Zhai Mengyao , Shi Qiufeng , Ivanovskikh Konstantin V. , Qiao Jianwei , Wang Lei , Guo Haijie , Huang Ping , Wang Xiao-Jun
Published: September 2023

A series of Mn4+ doped BaLa(Na/Li)WO6 and BaLaLi(W/Te)O6 phosphors were synthesized and studied. Substitution reactions of Na+ by Li+ and W6+ by Te6+ allows the management of the energy gap between Mn4+ 2Eg and 4T2g states and improves the thermal stability of the phosphors.
Application of arginine-doped PEDOT:PSS as a hole transfer layer in perovskite solar cells
Authors: Yang Yuanlin , Yao Yanqing , Li Ying , Zhao Xusheng , Cheng Wan , Chen Banghui , Chen Lijia , Li Ping , Tang Shuhui
Published: September 2023

Arginine was employed as an additive in the PEDOT:PSS solution to facilitate the transformation of PSS-H to PSS-NH3, aiming to address the challenges associated with excessive acidity and substantial interface energy dissipation in the HTL.
Small molecule-incorporated SnO2 layer for efficient perovskite solar cells
Authors: Zhou Xin , Kong Rui , Liu Rong , Liu Ying , Liang Mao , Shen Zhitao , Li Fumin , Jin Mengqi , Yang Dong , Wang Shengmin , Li Huilin , Cao Ruirui , Chen Chong
Published: September 2023

High-performance perovskite solar cells with a power conversion efficiency of 22.64% and high stability were prepared using the strategy of passivation of perovskite films by pre-burying the SSB molecule into SnO2.
NEUROPHYSIOLOGICAL STUDY OF GENE THERAPY EFFECT ON MOUSE MODEL OF METACHROMATIC LEUKODYSTROPHY
Authors: Amadio S. , Trojani A. , Del Carro U. , Biffi A. , Dolcetta D. , Consiglio A. , Martino S. , Quattrini A. , Bordignon C.
Published: September 2023

Aim of the study: To evaluate with neurophysiological methods whether gene therapy may improve the abnormalities of motor system in mice with Metachromatic Leukodystrophy (MLD). Methods: 2 groups were studied: the first one consisted of 11 mice (AS2‐/‐) knocked‐out for Arylsulfatase A (ARSA) gene; the second one included 10 mice (AS2‐/‐tr) which, after lethal irradiation, were transplanted with autologous hematopoietic stem cells transducted with a retroviral vector containing the ARSA cDNA. Both groups underwent Motor Evoked Potentials (MEP) by transcranial electrical stimulation of motor cortex, as well as Motor Conduction Velocity (MCV) of ischiatic nerve and compared with a control group (n=11). Results: The mean latency of cortical MEP was shorter in AS2‐/‐tr than in AS2‐/‐ group of mice (4.9 ± 0.2 versus 6.8 ± 1.2 msec; p<0.001), being quite similar to controls (5.1 ± 0.4 msec). The mean MCV was higher in AS2‐/‐tr as compared to AS2‐/‐ group (27.1 ± 4.5 versus 22.8 ± 3.0 m/sec; p<0.05), even though significantly slower than controls (37.7 ± 3.8 m/sec). Comments: The neurophysiological data show that gene therapy seems to prevent ARSA deficient mice from developing a functional damage of corticospinal pathways. They also suggest that peripheral neuropathy has a slower course in mice treated with gene therapy, although motor nerve fibers are not completely spared.
SURGICAL TREATMENT OF GLOSSOPHARYNGEAL NEURALGIA: A 10 YEAR EXPERIENCE
Authors: Rychlicki F. , Morabito L. , Dobran M. , Mora A. , Pauri F. , Ricciuti R.A. , Trignani R. , Veronesi V.
Published: September 2023

First described by Weisenburg in 1910, glossopharyngeal neuralgia is paroxysmal, lighting, excruciating pain referred to the posterior lingual region, tonsillar pillar, throat, external auditory canal and pinna. It is much less frequently encountered than trigeminal neuralgia with a reported relative frequency of the order of 1%. It is often secondary to neoplastic processes of the oropharyngeal region but can also be caused by mechanical compression of abnormal vessels on the nerve root. Less frequently it is of essential or idiophatic origin. Between 1990 and 2000, operations were performed at our Institute on 3 patients, all women ranging in age from 61 to 80 years, with glossopharyngeal neuralgia. All the patients had been taking caramazepine with only temporary initial improvement and in 2 cases parenteral feeding had been necessary before admission. The first 2 patients were submitted to percutaneous thermocoagulation rhizotomy of the inferior petrous ganglion of Andersch at the jugular foramen, the third to open procedure consisting in vascular decompression of the ninth nerve in posterior fossa. The follow‐up ranges from 2 to 10 years. The results were excellent or very good in all cases at the time of evaluation.

The authors emphasize the role of surgical therapy in glossopharyngeal neuralgia when medical therapy fails.
Improved hybrid discretisation of volume integral equation with the characteristic basis function method for analysing scattering from complex dielectric objects
Authors: Huang Fei , Sun Yufa , Li Ming , Wang Dalei
Published: September 2023

The improved hybrid discretisation of volume integral equation (VIE) combined with the characteristic basis function method is proposed to analyse the scattering from complex dielectric objects in this study. To mitigate the excessive number of discrete elements which arise from the conformal discretisation on the complex dielectric objects, the hybrid discretisation is developed. For the conventional hybrid discretisation, the conformal Schaubert–Wilton–Glisson (SWG) basis functions are used to discretise the homogeneous regions, meanwhile, the non‐conformal half‐SWG basis functions are employed to discretise the boundary regions which separate different materials or multiscale structures. The hybrid discretisation takes advantage of the merits of both conformal and non‐conformal basis functions and improves the computational efficiency for solving the VIE. In our study, a kind of edge basis function defined within boundary tetrahedral elements substitutes for the SWG basis functions to model the boundary regions, leading to the further reduction on the number of basis functions. Moreover, the characteristic basis functions extracted from the low‐level basis functions are employed to construct the reduced matrix of which the size is considerably smaller than that of the system matrix derived from the VIE. Several numerical results are presented to demonstrate the accuracy and efficiency of the proposed method.