bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthetic analogues of netropsin and distamycin--synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics.
Authors: Bartulewicz D , Bielawski K , Markowska A , Zwierz K , Pućkowska A , Rózański A
Published: January 2020

A new series of pyridine-containing analogues III-XXII of distamycin A and netrop sin was investigated by the molecular mechanics technique and molecular modelling. A pyridine analogue of netropsin (VII) is described, the first compound based on molecular studies, and two carbocyclic analogues of distamycin A with an N-terminal chloro- or bromoacetyl group (VIa, VIIa) were synthesized, as well as carbocyclic analogues of netropsin (VIIIb, Xb), potential carriers of alkylating elements. The potential use of VIa, VII, VIIa, VIIIb and Xb as carriers to place into the minor groove of DNA chemical groups capable of modifying DNA, is discussed.
Caminhos do rio Xingu: povos, paisagens e belezas naturais no médio Xingu
Authors: Ferreira Dilma Costa
Published: January 2020

O Rio Xingu, nasce no estado do Mato Grosso, na região da Parque Indígena do Xingu, a partir da confluência de outros rios. Esse rio é fonte de vida para diversos povos, sobretudo indígenas e ribeirinhos, e suas margens são habitadas por vários povos. No Alto Xingu, além das diversas etnias que vivem no Parque Indígena, o Rio atravessa a Terra Indígena Capoto/Jarina, onde habitam os Kayapó Setentrional, também considerados Mebengôkre, isto é, “gente do buraco da água”. Já no Médio Xingu, região de realização deste ensaio fotográfico, em particular no município de São Felix do Xingu-PA, suas águas atravessam grande parte da Terra Indígena Kayapó, onde também residem a maior parte dos Mebengôkre/ Kayapó Setentrionais. É nesse município que o Rio Xingu recebe um grande contributo do Rio Fresco, proporcionando uma paisagem graciosa, na qual se aprecia um pôr do sol exuberante diante do abraço dos rios. O Baixo Xingu também é palco de uma natureza riquíssima, abriga ribeirinhos e povos indígenas, como os Araweté e outras etnias. Recebe vários outros afluentes, com destaque para o Rio Iriri, antes de chegar ao final de seu curso fluvial. Entretanto, este ensaio visa evidenciar paisagens, experiências e vivências dos povos tradicionais que habitam o Médio Xingu, demonstrando a riqueza do Rio que alimenta, encanta, serve como fonte de renda através de sua flora e fauna aquática, e no caso dos indígenas também funciona como fonte de conhecimentos tradicionais e  como palco de práticas xamânicas.
Sinzhi warmiguna: notas sobre política e gênero entre as/os Sarayaku Runa
Authors: Santos Marina Ghirotto
Published: January 2020

Este artigo aborda relações entre (cosmo)política, liderança, território e gênero entre as/os Sarayaku Runa, povo kichwa da Amazônia equatoriana. Uma das traduções para “a política” é a expressão “hatun yuyayguna kwintanakuy”, que significa “conhecimento e/ou grande/importante conversa” ou “conversatório”. Dedico especial atenção a algumas mulheres líderes – puxadoras de conversatórios –, bem como a algumas das “coisas”que fazem e, ao mesmo tempo, as fazem, como a chagra (roçado) e a aswa (chicha ou cerveja de mandioca). Esta atenção sugere formas “femininas” e/ou de “mulheres” de territorializar o mundo e a política, deslocando a dicotomia moderna-ocidental do público como domínio da política e dos homens vs. privado/doméstico como o plano das mulheres.
Agência das mulheres Sanöma e a ativação de cosmopolíticas
Authors: Guimarães Sílvia Ferreira
Published: January 2020

Este artigo discute as experiências das mulheres indígenas Sanöma quando acionam uma cosmopolítica (Stengers 2018), quando desaceleram a construção de um mundo comum, englobante, e articulam mundos múltiplos. Em tais situações, narrativas hegemônicas atreladas a ações estatais no campo da saúde passam a ser questionadas. Omovimento dessas mulheres explode caminhos já consolidados para atingir outros fios de convivência, atuando sobre processos colonizadores que pretendem promover uma tensão nas socialidades indígenas, ao fazerem atransferência de práticas ocidentais de cuidado que questionam saberes das mulheres indígenas. Assim, elas resistem na infrapolítica. A agência dessas mulheres tem a potência, em si, de constituir realidades que recusam os significados e a organização social estruturados pelo poder ocidental.
O perigo do olhar da mulher: reflexões sobre gênero e perspectiva a partir de um ritual de iniciação masculina matses
Authors: Matos Beatriz De Almeida
Published: January 2020

O artigo trata da diferenciação de gênero entre os Matses a partir da etnografia de um ritual de iniciação masculina, a festa dos “espíritos cantores”, procurando mostrar como o ritual e as práticas de constituição da pessoa se relacionam à produção dessa diferenciação, e como ela se dá na relação com a alteridade. Indagando sobre o perigo da exposição dosespíritos ao olhar feminino fora do contexto correto estabelecido pelo ritual, e relacionando o ritual dos espíritos cantores a outros rituais de visita realizados entre os povos Pano (onde coletivos de homens e mulheres encarnam “visitantes” e “anfitriões” e se “enfrentam” em combates jocosos), o artigo sugere uma articulação entre a diferenciação de gênero e a diferença de perspectiva (Lima 1996; Viveiros de Castro 1996), ainda pouco explorada na etnologia amazônica.
Self-promotion of TV Stations from a Rhetorical Perspective. Persuasion Techniques
Authors: Sobczak Barbara
Published: January 2020

This paper discusses the persuasive techniques employed by media broadcasters in the self-promotional activities of television stations. A persuasive technique is understood as a specific manner of conduct of a broadcaster in the process of communication in which in order to increase their impact, a broadcaster emphasises or modifies some elements of the process. The starting point is the assumption that the selection of the persuasive techniques is related to such rhetoric determiners as the context of the operations of the media (consequences of technological changes: unification of media products, overwhelming increase in the amount of information, and ever growing global competition), the intended recipient, and the aim a broadcaster intends to achieve. The research material enabled the identification of the persuasive techniques in the self-promotional activities of media broadcasters emoployed at three levels: (1) mode of conveying information (e.g. repeating, and inherited audience); (2) content (e.g. positive selection technique, fragmentation, utilisation of the inaccessibility principle, emphasising the benefits of interacting with a medium, increasing the attractiveness of a communication by referring to broadly understood authority figures); and (3) form of communication (the technique of uniqueness).
“Gawęda radiowa”. The Works by Masters of Talk Radio (Using the Examples of Selected Shows from the Polish Branch of RFE)
Authors: Tatarowski Konrad Witold
Published: January 2020

The article includes a definition and a description of radio gawęda (or talk radio show) in comparison to the literary gawęda, and a discussion of its various genre variants, using the examples of radio shows by Zygmunt Nowakowski, Alfred Zbyszewski, and Tadeusz Nowakowski, and the television shows by Jerzy Waldorff and Bogusław Kaczyński.
Instructional leadership and its relationship with some variables
Authors: Coban Omur
Published: January 2020

The purpose of this study is to investigate the instructional leadership and its relationship with some variables such as gender, educational status, career and working year in the same school in Turkey. The study conducted with 614 teachers at 45 schools all over Turkey in the 2017â€“2018 academic year. Data were collected via instructional leadership scale which was applied to teachers and it had two dimensions: trust and focus on instruction. The findings showed that teachersâ€™ perception of trust about school administrators had a significant relationship according to their gender. In other words, male teachers thought school administrators more trustful than female teachers. Another result indicated that perceptions of teachers on instructional leadership had no significant relationship according to teachersâ€™ educational status and their career years. However, teachersâ€™ perceptions of school administratorsâ€™ focusing on teaching had a statistically significant relationship to teachersâ€™ working years in the same school.

Keywords: Instructional leadership, age, gender, career year, working years in the same school.
Promoting educational work using modern educational assessment tools: Creating and implementing rubrics for assessing projects and the cultivation of 21st-century skills
Authors: Kouloumpis Dionisios , Papageorgiou Theodora , Îšasimatis Îšaterina
Published: January 2020

The purpose of this study is to highlight the effectiveness of the use of rubric as a modern technique for teaching and assessing educational work. More specifically, our purpose is to explore the benefits of the implementation of the rubric for the project assessment in comparison with other traditional assessment techniques as far as the development of skills and the improvement of the educational work is concerned. The analytical rubric that was created and employed in the study included the following criteria (each with pre-determined quality levels): content completeness, structure and organisation, creativity, development of skills and cognitive concepts. This processing tool automatically quantifies the gradient of the criteria and automatically completes the final descriptive evaluation. It has a modern pedagogical scientific approach and flexibility, which gives impetus to creative projects in school. Six teachers of a Greek high school in Athens participated in the study. Data were collected through a semi-structured interview. The nature of the study was qualitative. The results revealed that the rubric can replace any other traditional technique. The tool allowed the students to evaluate their efforts, thus allowing them to realise the usefulness of the rubric as a self-assessment tool. Moreover, by using the rubric the students and the teachers had the chance to communicate constructively. The teachers and the students assessed the rubric in a positive way as the students were led to self-assessment processes through reflection and feedback and the development of cognitive and metacognitive skills.

Keywords: Authentic assessment project, rubric, assessment criteria, reflection, 21st-century skills.
Korpus uteri kanserlerinin epidemiyoloji ve sağ kalım özellikleri
Authors: AKMAN Levent , YILDIRIM Nuri , TEREK Mustafa Coşan , ÖZSARAN Zeynep , ALANYALI Senem , HAYDAROĞLU Ayfer , ŞANLI Ulus Ali , GÖKER Erdem , ZEKİOĞLU Osman , ÖZDEMİR Necmettin , ÖZSARAN Ahmet Aydın
Published: January 2020

Amaç: Ege Üniversitesi Hastanesinde 1992-2017 arası kanser tanı ve tedavisi yapılan 3379 korpus uteri kanserinin epidemiyolojik ve sağ kalım özelliklerini analiz etmek ve sonuçları literatürle karşılaştırmaktır.

Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezi tarafından toplanan korpus uteri kanseri verileri CANREG özel bilgisayar programına kayıt edilmiş, DSÖ ve SEER sistemleri temelinde gruplanarak analizler yapılmıştır. İstatistik analizlerde Ki-kare, General Linear Model, Kaplan Meier sağ kalım analizleri uygulanmıştır. Kaplan Meier Sağ kalım analizinde Log Rank (Mantel-Cox), Breslow (Generalized Wilcoxon) ve Tarone-Ware istatistikleri kullanılmıştır. İstatistik analizlerde p
A Perspective on over 1000 Psychobooks for Psychiatry and Psychology Training
Authors: Gama Marques João , Barreto Elias , Moniz Pereira Francisco , Fernandes Isabel , Durval Rui , Bento António
Published: January 2020

N/a.
EOSINOPHILIA AS A PREDICTOR MORBIDITY OF SOIL- TRANSMITTED HELMINTHIASES AMONG WIDODAREN PLANTATION WORKERS IN JEMBER
Authors: Primadana Aditya , Nurdian Yudha , Agustina Dini , Hermansyah Bagus , Armiyanti Yunita
Published: January 2020

Background: Helminthiasis is a neglected tropical disease and still remain a health problem in tropical and sub-tropical countries, including Indonesia. According to WHO, approximately 1,5 billion people or 24% of the world’s population, are infected with Soil-Transmitted Helminth (STH). Morbidity is directly related to the intensity of STH infestation. Some of the studies shown a significant correlation between eosinophilia and helminthiasis. Eosinophilia on the blood smear examination may be used as a marker of STH infestation. Purpose: to determine the correlation between Soil-Transmitted Helminthiases and eosinophilia as a predictor of morbidity of STH infestation among Widodaren Plantation Workers in Jember. Methods: This observational analytical study use the Kato-Katz method to determine infestation of STH and its intensity measured by egg count per gram stool (EPG). Blood smear examination stained with Giemsa conduct to determine eosinophil count. Results: Prevalence of STH infestation was 22,7% (15/66). Ascaris lumbricoides infection was 13,6% (9/66) and Hookworm infection was 4,5% (3/66). There is mixed infection between A. lumbricoides and Hookworm, the prevalence was 4,5%% (3/66). All of the infection intensity was light. The prevalence of eosinophilia was 27,2% (18/66). There was a significant correlation between STH infection and eosinophilia (P=0,000) but, there was a very weak correlation between the intensity of STH infection and eosinophilia (r=0,281; p=0,258). Conclusion: The prevalence of STH infection among Widodaren Plantation Workers is 22,7% and predominated by A. lumbriocides. There is a positive correlation between intensity of STH infection and eosinophilia as predictor morbidity of STH infection with very weak power.
DIFFERENT OF HEMATOCRIT VALUE MICROHEMATOCRIT METHODS AND AUTOMATIC METHODS IN DENGUE HEMORRHAGIC PATIENTS WITH HEMOCONCENTRATION
Authors: Meilanie Alvin Dwi Rizky
Published: January 2020

Background: Many people in Indonesia. Hematocrit examination is one of the important examinations to help diagnose dengue fever. Increased hematocrit (hemoconcentration) occurs with dengue hemorrhagic fever caused by plasma leakage. Hematocrit examination can be done by microhematocrit method and automatic method. The microhematocrit method has the principle that the blood with anticoagulants is centrifuged at a certain speed, the erythrocytes will separate from the plasma. While the automated hematology analyzer uses the principle of flowcytometry which detects based on the height of the erythrocyte pulse. Purpose: To know the differences in hematocrit values of the microhematocrit method and the automatic method in patients with hemoconcentration of Dengue Hemorrhagic Fever. Methods: The study was conducted by observational analytics in March 2019 with a total of 30 samples at RSU. Haji Surabaya. The data obtained was analyzed using the Paired Sample T-Test with the SPSS 16.0 program to determine whether there were significant differences in hematocrit values between the microhematocrit method and the automatic method. Results: The results showed that the hematocrit examination results of microhematocrit method obtained an average of 46.93%, while the automatic method obtained an average of 45%. This shows the hematocrit examination results of the microhematocrit method are higher than the automatic method. Based the results of paired sample statistical tests t Tests obtained a significance value of 0.00 were less than 0.05. Conclusion: There are significant differences between the hematocrit examination results of the microhematocrit method and the automatic method.
The Influence of International Tax Policy on the Indonesian Tax Law
Authors: Anggia Putri
Published: January 2020

By 2012, the Indonesia government had validated Law Number 9 of 2017. One of the content is finance information government access to the customer bank and to the taxpayer. The government has considerations. First of all, Government will be open the access limitation of banking automatically that is necessary for taxation. The second, Indonesia has committed to international agreements of taxation which is obliged to fulfill the commitment. The commitment is to participate in implementing Automatic Exchange of Account Information (AEOI). Based on the policy, several managements and flow process around the banking area changed. Moreover as the customer bank are affected. The registration for the customer bank have been starting since 2018. By the earlier 2019, the progress of the administration needed to be checked and to be evaluated. This paper tries to discuss this issue based on the academic point of view. Data were obtained through library research. The library research was done by documentary study by collecting and analyzing selected laws and regulations, books, articles, journals and other documents which were relevant to the research. All datas were analyzed qualitavely. The implication of this research brings up a new idea about the theory of bank secrets. Initially, it is consisted of two theories, namely are absolute and relative. Despite of the two, there is a big affect in theory and academic knowledge about the validation of the agreement Indonesia government.
State Owned Enterprises Finance from the Perspective of State Funds
Authors: Sitepu Sopian
Published: January 2020

The existence of State-Owned enterprises (SOE) as one of Indonesia’s legal entities, whereby the State owns part of all of the capital of the company has presented several legal issues. The BUMN Act that has become the basis for establishing State-Owned enterprises has become its own independent legal subject and separates itself from the wealth of the State and has adhered to the provisions of the Company Law Act so that the capital that is presented by the State to the corporation remains as the capital of the SOE and not form the State. However, existing legislations regarding State funds places the funds for SOE as being part of the State budget. This ambiguity in the status of BUMN Funds is not only found in legislations but also in two different constitutional court decisions that presents inconsistencies towards law enforcers. This clear distinction is crucial in the practice of law enforcement in Indonesia.
ASEAN vs. WTO DSM: Overcoming Jurisdiction Issues to Encourage Regional Trade Agreements’ System Efficacy
Authors: Udomjitpittaya Wisawawit , Fitriana Zuhda Mila
Published: January 2020

Dispute settlement mechanism holds an important role in upholding the rights and obligations of member countries under any agreements signed by ASEAN members as well as to resolve any dispute between Members, therefore, AFTA has its own dispute settlement procedure. Unfortunately, it has not been fully efficient to solve the trade dispute within ASEAN countries because the parties tend to bring their disputes to WTO Dispute Settlement Body (DSB). This is because there are some issues and constraints in the AFTA DSM which vary from technical issues to cultural issues. Specifically, although there has not been any overlap issue with the WTO, the AFTA DSM might have the possibility to create such issue due to the lack of efficieny in the legal framework. It also has another major issues such as difficult access for private parties to defend their rights and the disputes in AFTA are rarely resolved because of the ‘ASEAN Way’ method. The ongoing reliance of ASEAN Member States to WTO DSB is an unfortunate situation knowing the fact that the WTO DSB has been struggling with overlap jurisdiction issues with other RTAs throughout the years. The aims of this writing is proposing possible solutions to encourage the efficacy of RTA’s DSB usage particularly in ASEAN Region.
Indonesia’s Patent Policy on the Protection of Genetic Resources related Traditional Knowledge; Is it a Synergy to Fulfill the TRIPs agreement and CBD Compliance?
Authors: Barizah Nurul
Published: January 2020

This research analyses the compatibility of Indonesian Patent Act with the Trade related Aspect of Intellectual Property Rights (TRIPs) Agreement and the Convention on Biological Diversity (CBD) dealing with Genetic Resources Related to Traditional Knowledge (GRTK). The focus this analyses on whether the new Indonesian Patent Act provides a clear policy on the protection of GRTKF and the development of the biotechnology in Indonesia, particularly on the patentability of genetic resources related inventions, including genes patent. This research found that the new Indonesian Patent Act on GRTK is not only to synergise between the TRIPs Agreement obligation and the CBD compliance, but also adopted patent policies derived from other developed countries particularly in examining the patentability thresholds and exceptions from patentability. Even, in the context of patentability of living organisms, Indonesia adopts a very liberal approach compared to most industrialised countries. This research advises that Indonesian patent policy on GRTK should take into account the richness of this country on biodiversity and the level of biotechnology industry development.
MAX WEBER ON POLITICS, REASON, AND THE CLASH OF VALUES AND APPROACHES TO ETHICS
Authors: KNOLL Manuel
Published: January 2020

This article investigates how Max Weber’s theory of value conflict is connected to his realist understanding of politics and how he conceives the relation of politics and ethics. This investigation also covers Weber’s views on the argumentative limits of the social sciences and ethics. The center of Weber’s philosophy of science is constituted by his methodological thoughts on “ethical neutrality” (Wertfreiheit) of the social sciences. The first thesis of this paper contends that Weber’s theory of a clash of irreconcilable values and ideals goes back to Nietzsche. According to the second thesis of the article, the general claim of Weber’s philosophy of science is that there is no possibility of an ultimate rational, philosophical, or scientific grounding of values and normative theories. Weber’s endorsement of an ethics of responsibility in the field of politics led to the criticism that he contradicts his postulate of the “ethical neutrality” (Wertfreiheit) of the scientist. The third thesis of the paper claims that Weber’s arguments for a political ethics of responsibility are compatible with his methodological postulate.
The Mystics of al-Andalus: Ibn Barrajan and Islamic Thought in the Twelfth Century
Authors: AYTEP Ahmet
Published: January 2020

Gerek popüler kültür gerek akademik camiada ilgi odağı olmaya devam
eden Endülüs mistikleri, bir okul olarak bütüncül ve detaylı bir şekilde çalışılmayı
beklemektedir. Araştırmacılar Endülüs mistiklerinin genel olarak
İslam düşüncesi üzerindeki önemli etkilerini vurgulamakla birlikte, sadece
İbn Meserre (ö. 319/931) ve İbn Arab (ö. 638/1240) gibi IV/X. ve VII/
XIII. yüzyılın öne çıkan isimleri hak ettikleri ilginin bir kısmını görmüşlerdir.
1 Ne var ki bu iki dönem arasında geçiş rolü üstlenen İbn Berrecân
(ö. 536/1142), İbnü’l-Arîf (ö. 536/1141) ve İbn Kasî (ö. 546/1151) gibi erken
VI/XII. yüzyıl teşekkül dönemi temsilcileri kısmen ihmal edilmiştir
Mucizelerle Hz. Peygamber’in Hayatı
Authors: AYDIN Muhammet
Published: January 2020

Kadı Abdülcebbar (ö. 1025) yalnız Mutezile kelamının değil genel manada
Kelam geleneğinin önemli isimlerinden birisidir. Eserleri yaşadığı
dönemin siyasal, sosyal ve entelektüel atmosferinin daha iyi anlaşılmasını
sağlar. Öte yandan Delâil literatürüne gelince, bu tamlama nübüvvet konusuyla
yakından ilgilidir. Delâilü’n-Nübüvve, bir peygamberin hak ve sadık
olduğunu ispatlamak için bizzat gösterdiği veya peygamberliğine alamet
olmak üzere kendisi dışında meydana gelen tabiatüstü olayları konu edinen
eserleri ifade eder.
Energy Demand Relationship: Theory and Empirical Application. A Short Note
Authors: Hasanov Fakhri J. , Mikayilov Jeyhun L.
Published: January 2020

In this short note, the described step-by-step derivations of the industrial energy demand function from the production function framework and provided researchers with two specifications. Then we applied these theoretical specifications to the time series data as empirical analysis. We concluded that theories should be considered at the beginning of the empirical analyses but the data also should be allowed to speak freely. Hence, the main suggestion of this short note is that it would be a better strategy to consider the combination of theory-driven and data-driven approaches in the empirical analyses.
Keragaman Morfologi Talas (Colocasia esculenta L.) Lokal Papua
Authors: Wulanningtyas Heppy Suci , Sabda Muhamad , Ondikeleuw Mariana , Baliadi Yuliantoro
Published: January 2020

Talas (Colocasia esculenta L.) merupakan salah satu makanan pokok penduduk asli Papua dan tersebar di hampir semua wilayah Papua. Untuk menjaga kelestarian dan mencegah punahnya aksesi lokal talas, BPTP Balitbangtan Papua melakukan eksplorasi dan karakterisasi sumber daya genetik (plasma nutfah) talas di enam kecamatan yang menyebar di empat kabupaten/kota dan terkumpul sepuluh aksesi. Kegiatan ini bertujuan untuk mengoleksi dan mengarakterisasi aksesi talas lokal Papua. Kegiatan terdiri dari koleksi, karakterisasi, dan dokumentasi. Pengumpulan data awal aksesi meliputi nama lokal, manfaat bagi masyarakat lokal dan umur panen diperoleh melalui wawancara ke penduduk setempat, sedangkan pengamatan karakter tanaman dilakukan melalui karakterisasi dan dokumentasi. Karakterisasi dilakukan berdasarkan Descriptors for Taro dari International Plant Genetic Resources Institute dan Panduan Karakterisasi dan Evaluasi Plasma Nutfah Talas dari Komisi Nasional Plasma Nutfah meliputi rentang tanaman, tinggi tanaman, jumlah stolon, panjang daun, lebar daun, rasio panjang pelepah/panjang petiol, warna helai daun, warna tulang daun, pola tulang daun, bentuk permukaan helai daun, irisan melintang petiol, lapisan lilin, bentuk umbi, warna kulit ari, warna daging umbi, panjang umbi, lebar umbi, dan bobot umbi. Berdasarkan hasil eksplorasi diperoleh sepuluh aksesi talas lokal Papua dengan ciri-ciri umum warna batang hijau, ungu dan merah yang yang memiliki umur panen yang sama, yaitu 6–9 bulan. Warna daun dominan hijau dengan warna tulang daun yang bervariasi yaitu putih, kuning, hijau, merah muda, dan ungu. Keseluruhan pola tulang daun berbentuk ”Y” dengan bentuk permukaan helai daun secara dominan tegak dengan ujung ke bawah. Delapan aksesi memiliki irisan melintang petiol tertutup dan tidak ada lapisan lilin pada permukaan daun. Sepuluh aksesi tersebut memiliki warna daging umbi yang berbeda-beda seperti putih, krem, putih keunguan dan ungu muda. Bentuk umbi adalah silindris, elips, kerucut, dan membulat. Tujuh aksesi memiliki tinggi tanaman >1 meter, enam aksesi memiliki jumlah stolon >5 dan berpotensi untuk dibudidayakan dalam skala luas. Panjang umbi berkisar antara 10–23 cm dengan lebar 5–10 cm. Satu aksesi memiliki bobot umbi yang tergolong tinggi yaitu 800 gram dan berpotensi menghasilkan tepung yang lebih banyak.
EFFECTS OF TIME BUDGET PRESSURE, AUDIT FEE, INDEPENDENCE AND COMPETENCE ON AUDIT QUALITY
Authors: Kurniawan Gevi , Ngumar Sutjipto , Kurnia -
Published: January 2020

This study aims to examine the determinants of audit quality, which employs a quantitative method by conducting a survey on 98 public accountants in East Java across of 58 public accounting companies. The findings indicate that audit fee, independence and competence affect audit quality. However, there is no effect of time budget pressure on audit quality, which indicates that the auditors have tendency to maintain audit quality even under time budget pressure.
The Impacts Of Inbound Tourism Activities And Macroeconomic Variables On Environmental Degradation In Asean-4
Authors: Widiarso Ekan , Wilantari Regina Niken , Luthfi Agus
Published: January 2020

This study aims to analyze the impacts and causal relationship between inbound tourism activities and macroeconomic variables on environmental degradation and  to analyze the environmental degradation response due to shocks that occur in inbound tourism activities and macroeconomic variables in four countries with the highest international tourist visits in the ASEAN region of Indonesia, Malaysia, Singapore and Thailand known as ASEAN-4 for Periode 1995-2015. The method used in the research is panel vector error correction model (PVECM). The results showed that inbound tourism activities positively influence in the long-term and short-term  environmental degradation in ASEAN-4. Among  macroeconomic variables only gross domestic product (GDP) positively affects environmental degradation in the long term and short term whereas energy consumption only affects environmental degradation in the short term. There is a direct causal relationship of inbound  tourism activity with environmental degradation and environmental degradation with GDP. Energy consumption and environmental degradation manifest  bidirectional causality with a feedback effect. Impulse response function indicates environmental degradation responds negatively to the shocks that occur in Inbound tourism and GDP activities. The positive response is indicated by environmental degradation in case of shock to energy consumption.
Perforacja żołądka jako powikłanie endoskopowej cholangiopankreatografii wstecznej – opis przypadku
Authors: Modrzejewski Andrzej , Śledź Marcin , Parafiniuk Mirosław , Paśnik Bartosz , Nowak Tomasz
Published: January 2020

ABSTRACTEndoscopic retrograde cholangiapancreatography (ERCP) is an invasive diagnostic and therapeutic procedure in bile duct diseases. These procedures have severe complications, yet gastric perforation hasn’t been presented in literature.We present a case study of an 82 year old woman admitted to hospital due to suspected choledocolithiasis. The patient underwent two ERCP procedures. Due to acute abdominal pain, abdominal radiography was also performed. The examination revealed intraperitoneal free air. The patient underwent open repair of the perforated stomach. The second day after surgery the patient suffered multiorgan failure and was transmitted to the intensive care unit where she died 2 days later.
Analysis of the reasons for ambulance being called for out of hospital sudden cardiac arrest. A retrospective multi-center study
Authors: Kłosiewicz Tomasz , Skitek-Adamczak Ilona , Zieliński Marcin , Zalewski Radosław , Dąbrowski Marek , Rut Andrzej , Maciejewski Adrian
Published: January 2020

Introduction: The survival of sudden cardiac arrest (SCA) in addition to rapid diagnosis, implementation of high-quality cardiopulmonary resuscitation, immediate defibrillation also depends on the effective dispatching and cooperation of the emergency medical team members.

Materials and methods: The research was a retrospective analysis of medical documentation kept in 2015. The provisions regarding interventions were analyzed in patients who were diagnosed with sudden cardiac arrest during the first medical contact undertaken by the emergency medical team – a total of 1136 events.

Results: The mean age of SCA patients was 69.33 years. The main reason of calls was SCA (26.53%) and loss of consciousness (22.53%) although more than half of calls were connected other medical problems.

Conclusions: The results allow you to conclude, that calls such as syncope, chest pain or breathing disorders should be treated as high priority and dispatcher assistance until ambulance arrival should be performed to ensure rapid instructions in case of SCA.
Selected health problems of patients with acute pancreatitis treated in intensive care units
Authors: Polek Joanna , Radosz Zuzanna , Kozień Michał , Gniadek Agnieszka
Published: January 2020

Introduction: Acute pancreatitis (pancreatitis acuta) is one of the most common inflammatory diseases of the digestive system. It is a non-neoplastic disease characterized by an acute and rapid course. It is characterized not only by inflammatory changes in the pancreas itself but also in the surrounding tissues, and is associated with multiple organ failure in a severe stage of the disease. The aim of the study was to assess the frequency of occurrence of problems from acute pancreatitis and to present actions to eliminate them.

Materials and methods: The medical records of 50 patients with acute pancreatitis treated in an intensive care unit were analyzed. A survey form was used to input data from the medi cal records and provide scales for assessing the severity of acute pancreatitis. Correlations between selected variables were calculated.

Results: The majority were sick men aged 50+ who were retired for acute pancreatits. The most common cause of pancreatitis (n = 16) was alcohol dependence syndrome. The highest percentage of patients (n = 36) had necrotic – haemorrhagic forms of acute pancreatitis. No relationship was found between the length of stay of the patients in intensive care and the occurrence of such nursing problems as edema. In contrast, patients fed parenterally had a tendency to hyper-glycaemia. 16 respondents according to the Apache II scale had a 40% risk of death.

Conclusions: In acute pancreatitis, due to the limited independence of the patient, nursing care is very important, with the main goal to increase the patient’s comfort. It requires the cooperation of the entire therapeutic team with the patient and his family.
SAPHO syndrome in children – case reports
Authors: Wojciechowski Piotr , Strzelczuk-Judka Lidia , Klimecka Iwona , Jończyk-Potoczna Katarzyna
Published: January 2020

Introduction: SAPHO syndrome is a heterogeneous disease of unknown pathogenesis characterized by osteoarthritis and concomitance of skin lesions. The most common sites of lesions are sterno-clavicular joints and sterno-costal joints. Skin symptoms include palmoplantar pustulosis and acne lesions. The disease can occur in any age group, the spectrum of symptoms is broad and characterized by different dynamics of changes.

Cases report: The paper presents cases of SAPHO syndrome and diagnostic difficulties connected with it from case reports of two pediatric patients aged 10 and 8 years admitted to the hospital due to pain of the sternocostoclavicular region. Differential diagnoses included oncological, hematological, infectious, orthopedic, immunological and rheumatological diseases.

Diagnostic imaging showed characteristic changes in the affected regions. The disease process corresponded to SAPHO syndrome. Follow up visits by the patients are presented to evaluate the effectiveness of treatment, including magnetic resonance imaging and computer tomography.

Conclusions: The presented cases indicate attention to the possible course of SAPHO syndrome. It is an interdisciplinary disease, which should not be forgotten as one of differential diagnosis of patients in each age group. Early confirmation of the diagnosis allows the use of appropriate treatment and avoidance of unnecessary diagnostic procedures.
Primary tumours of the optic nerve and the optic nerve sheath
Authors: Krasodomska Kamila , Lubiński Wojciech , Masztalewicz Marta , Cyryłowski Lech
Published: January 2020

Introduction: Glioma and meningioma, the 2 most common primary tumours of the optic nerve and optic nerve sheath are usually benign, slow-growing tumours.

The aim of the paper is to provide an overview of clinical, histo-logical and radiological features of the most common primary tumours of the optic nerve and optic nerve sheath, as well as to discuss available treatment options.

Materials and methods: A literature review was performed based on articles discussing optic nerve glioma and meningioma of the optic nerve sheath.

Results: Glioma is the most common primary tumour of the optic nerve. In 90% of the patients, the onset is within the first 2 decades of life. Meningioma is the most common primary tumour of the optic nerve sheath. In 95% of the sufferers, the onset is in adulthood. Although rare in the general population, primary tumours of the optic nerve and its sheath are seen more often in patients with neurofibromatosis (NF). Glioma more

often affect patients with NF1, whereas meningiomas more often affect those with NF2. Unlike in children, optic nerve glioma in adults can be malignant. On the other hand, optic nerve sheath meningioma tends to be more malignant in children rather than in adults. The symptoms of optic nerve glioma and optic nerve sheath meningioma can be similar, including vision impairment and proptosis. The diagnosis is based on orbital imaging with magnetic resonance image (MRI) or computed tomography (CT). The management most often involves clinical observation. Surgery, radiation therapy or chemotherapy are only used in selected cases with the risk of optic chiasm or fellow optic nerve involvement.

Conclusions: Primary tumours of the optic nerve and optic nerve sheath are rare. Consolidated knowledge and improved understanding can aide early diagnosis and proper management of such cases.
Prevalence of Demodex spp. in students and employees of the Pomeranian Medical University in Szczecin
Authors: Dołęgowska Katarzyna
Published: January 2020

Introduction: Demodex folliculorum and Demodex brevis are mites living in the hair follicles and sebaceous glands of humans, with infestation usually being asymptomatic.

In the present study the prevalence and number of mites, together with influencing factors of Demodex infestation, were investigated in students and personnel of the Pomeranian Medical University in Szczecin in Poland (PUM). The prevalence of 2 Demodex species, Demodex folliculorum and Demodex brevis, was compared in epilated eyelashes and skin scrapings derived from healthy volunteers.

Materials and methods: The study was conducted on 217 healthy volunteers – females and males. The study group consisted of 114 students and 103 employees of PUM. From each study participant, 2–3 eyelashes from each lid were epilated. From 99 volunteers, skin scrapings and/or secretions from sebaceous glands were also obtained. Demodicosis was diagnosed when Demodex eggs, larvae or adult mites were identified under microscopic examination.

Results: The infestation rate of Demodex (in epilated eyelashes and skin) among the 217 volunteers was 21%. Prevalence of hair follicle mites among personnel and students were 28% and 14% respectively. The mean number of mites among the 217 patients was 2.52 ±2.48 (3.16 ±2.9 in PUM personnel and 1.46 ±0.83 in students). The infestation rate increased with age (p = 0.0005). Demodex folliculorum infested 78% (p = 0.005) of the participants and 87.5% of epilated eyelashes (p = 0.000001). Demodex brevis was more frequent on the skin (67%; p = 0.00001). Hair follicle mites were detected more often in epilated eyelashes originating from the lower lid (p = 0.000001). Moreover, a weak correlation between the presence of selected symptoms (blepharedema, conjunctivitis, burning and itching of eyelids) and Demodex infestation was observed. There was no statistically significant association between Demodex infestation and an influencing factor: work using a microscope (p = 0.92).
Decline Curve Analysis Using Type Curves
Authors: Fetkovich M. J.
Published: January 2020

This paper shows that the decline-curve analysis approach does have a solid fundamental basis. The exponential decline is shown to be a longtime solution of the constant-pressure case. The constant-pressure infinite and finite reservoir solutions are placed on a common dimensionless curve with all the standard "empirical" exponential, hyperbolic, and harmonic decline-curve equations. Simple combinations of material balance equations and new forms of oil well rate equations for solution-gas drive reservoirs illustrate under what circumstances specific values of the hyperbolic decline exponent (1/b) or "b" should result.

Log-log type curve analysis can be performed on declining rate data (constant-terminal pressure case) completely analogous to the log-log type curve matching procedure presently being employed with constant-rate case pressure transient data. Production forecasting is done by extending a line drawn through the rate-time data overlain along the uniquely matched or best theoretical type curve. Future rates are then simply read from the real time scale on which the rate-time data is plotted. The ability to calculate kh from decline-curve data by type curve matching is demonstrated.

This paper demonstrates that decline-curve analysis not only has a solid fundamental base, but provides a tool with more diagnostic power than has previously been suspected. The type curve approach provides unique solutions upon which engineers can agree, or shows when a unique solution is not possible with a type curve only.
Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predicts poor prognosis in patients with breast cancer
Authors: Oba Takaaki , Maeno Kazuma , Takekoshi Daiya , Ono Mayu , Ito Tokiko , Kanai Toshiharu , Ito Ken-ichi
Published: January 2020

Background: The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid malignancies. This study aimed to evaluate the prognostic impact of PNI changes in patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). Methods: We reviewed patients with breast cancer who underwent NAC and a subsequent surgery for breast cancer between 2005 and 2016. PNI before and after NAC were calculated using the following formula: 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count/mm3. The relationship between PNI and prognosis was retrospectively analyzed. Results: In total, 191 patients were evaluated. There was no significant difference in disease-free survival (DFS) between the pre-NAC PNI high group and the pre-NAC PNI low group (cutoff: 53.1). However, PNI decreased in 181 patients (94.7%) after NAC and the mean PNI also significantly decreased after NAC from 52.6 ± 3.8 pre-NAC to 46.5 ± 4.4 post-NAC (p < 0.01) . The mean ΔPNI, which was calculated as pre-NAC PNI minus post-NAC PNI, was 5.4. The high ΔPNI group showed significantly poorer DFS than the low ΔPNI group (cut off: 5.26) (p = 0.015). Moreover, high ΔPNI was an independent risk factor of DFS on multivariate analysis (p = 0.042). Conclusions: High decrease of PNI during NAC predicts poor prognosis. Thus, maintaining the nutritional status during NAC may result in better treatment outcomes in patients with breast cancer.
Icotinib is as efficacious as gefitinib for brain metastasis of EGFR mutated non-small-cell lung cancer
Authors: Liu Kejun , Jiang Guanming , Zhang Ailing , Li Zhuanghua , Jia Jun
Published: January 2020

Background: The prognosis of non-small-cell lung cancer (NSCLC) with brain metastases is very poor. Currently, therapeutic methods for this patient population include whole-brain radiation therapy (WBRT), surgery, radiosurgery and systemic treatment. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) could be effective on cerebral metastases of mutated NSCLC. However, which EGFR-TKIs is more appropriate is still unknown. Methods: We conducted a retrospective analysis of advanced NSCLC patients with brain metastases for EGFR targeted therapy from November 2013 to April 2018 at Dongguan People’s Hospital, Southern Medical University, China. A total of 43 patients were recruit in this study. Among them, 21 cases received icotinib (125 mg, thrice a day) and 22 cases received geﬁtinib (250 mg, once a day) until disease progression or unacceptable toxicity. The primary end point of this study was intracranial PFS (iPFS). The relationships between therapeutic arms and patients characteristics were performed using Pearson’s chi-square test or Fisher’s exact test. The differences in PFS among the two arms were analyzed using Kaplan-Meier curves and log rank tests. Results: There was no significant difference of intracranial ORR (66.6% versus 59.1%, P =0.62) and DCR (85.7% versus 81.8%, P =0.73) between the two arms. The median intracranial PFS (iPFS) for icotinib and gefitinib arms were 8.4 months (95% CI, 5.4 to 11.3 months) and 10.6 months (95% CI, 6.3 to 14.8 months), respectively (P =0.17). Adverse events of the two study arms were generally mild. None of the patients experienced dose reduction of EGFR-TKIs. Conclusions: Our study showed that icotinib and geﬁtinib had similar efficacy for brain metastasis of EGFR mutated NSCLC. Large randomized studies are suggested to further illuminate the effect of these two EGFR-TKIs on cerebral lesions of NSCLC.
Quasimetagenomic source tracking of Listeria monocytogenes from naturally contaminated ice cream
Authors: Ottesen Andrea , Ramachandran Padmini , Chen Yi , Brown Eric , Reed Elizabeth , Strain Errol
Published: January 2020

Background

The more quickly bacterial pathogens can be linked to a vehicle of transmission or a source, the more illnesses can be prevented. Whole genome sequencing (WGS) based approaches to source tracking have greatly increased the speed and resolution with which public health response can pinpoint the vehicle and source of outbreaks. Traditionally, WGS approaches have focused on the culture of an individual isolate before proceeding to DNA extraction and sequencing. For Listeria monocytogenes (Lm), generation of an individual isolate for sequencing typically takes about 6 days. Here we demonstrate that a hybrid, “quasimetagenomic” approach ie; direct sequencing of microbiological enrichments (first step in pathogen detection and recovery) can provide high resolution source tracking sequence data, five days earlier than response that focuses on culture and sequencing of an individual isolate. This expedited approach could save lives, prevent illnesses and potentially minimize unnecessary destruction of food.
Methods

Naturally contaminated ice cream (from a 2015 outbreak) was enriched to recover Listeria monocytogenes following protocols outlined in the Bacteriological Analytic Manual (BAM). DNA from enriching microbiota was extracted and sequenced at incremental time-points during the first 48 hours of pre-enrichment using the Illumina MiSeq platform (2 by 250), to evaluate genomic coverage of target pathogen, Listeria monocytogenes .
Results

Quasimetagenomic sequence data acquired from hour 20 were sufficient to discern whether or not Lm strain/s were part of the ongoing outbreak or not. Genomic data from hours 24, 28, 32, 36, 40, 44, and 48 of pre-enrichments all provided identical phylogenetic source tracking utility to the WGS of individual isolates (which require an additional 5 days to culture).
Conclusions

The speed of this approach (more than twice as fast as current methods) has the potential to reduce the number of illnesses associated with any given outbreak by as many as 75% percent of total cases and potentially with continued optimization of the entire chain of response, contribute to minimized food waste.