bluuebunny/crossref_metadata_2025 huggingface dataset:
Yu.S. Semenov: from “Seventeen Moments of Spring” to “The Third Map”. “Encryption” of historical facts
Authors: Khvorova Liudmila E.
Published: November 2023

In a study based on the material of the author’s (source) text of the said novel (1973), a “verification” of the key provisions that became the basis of its complex polyphonic conflict was carried out. To achieve this goal, we mainly used the receptive method, which is widespread in modern literary research practice. The concept of “artistic historicism” is emphasized, both its similarities and differences from the realities of history, the details of the historical process. The understanding of the original artistic and documentary style of Yu. Semenov is continued – the specifics of historicism as the “ciphering” of historical facts, which began in the first part of the study. The author’s hypothesis about the “exit” of the conflict embedded within the artistic paradigm of the novel’s text on the geopolitical and psychological levels – into the real vicissitudes of world history in the middle of 20th – 21st centuries was analytically tested. In this regard, the key statements of documentary-fiction characters (A. Dulles, W. Churchill and W. Schellenberg), deliberately removed by the director from the film version (intertext) of the novel, are emphasized and studied. The emergence of a real global geopolitical conflict between the West and Russia of the era of “peace at war” (the author’s term of the article), formed in the spring of 1945, in the days of the approaching defeat of Nazi Germany, but originating in June 1941, is traced (Yu. Semenov’s novel “ Third card"). In conclusion, the foundations of this scientific research are formulated with verification of historical, geopolitical facts set out in the report of a modern Russian statesman, Director of the FSB of Russia, Secretary of the Security Council of the Russian Federation N.P. Patrushev (“They want to turn Russia into Muscovy”: document dated January 10, 2023).
Changes in the magazine segment of the domestic media industry in 2022–2023: rebranding of glossy publications
Authors: Zvereva Ekaterina A.
Published: November 2023

In a situation of intensive changes in society, the conditions for the functioning of companies change dramatically, and there is a need to transform the existing brand. In 2022, the reaction of domestic glossy publications to the objective conditions of the new reality is divided into three types: some closed, others remained the same, and others changed their brands. The research material is glossy publications that have carried out rebranding: TechInsider, “Novyi ochag”, The Symbol, Men Today, U Magazine, The VOICE, “Pravila zhizni”. The purpose of this research is to study the state of the magazine segment of the domestic media industry during the rebranding of glossy publications. The methods used in the course of our research include system analysis, in-cluding comparative and functional approaches. For a visual presentation of the research results, all its parts are built according to a single scheme: verbal and visual brand attributes, media con-tent (categorization), development strategy in the digital field, brand values. Evaluation of the re-branding nature comes from the fact of preservation or transformation of the value level. As a re-sult, conclusions are drawn that publications took advantage of the situation in different ways: most publications do not depart from the established global brand and carry out partial rebranding, while others, on the contrary, decide to continue functioning in a new form. A full-fledged rebranding is carried out by “The VOICE” and “Pravila zhizni”, completely changing both the external and internal appearance of the publication. The final table presents the results of the study and conclusions about the nature of the rebranding.
Transformation of dialogic genres in the online space: analysis and development prospects
Authors: Dyatlova Alina E. , Ilchenko Sergey N.
Published: November 2023

The main features of dialogic genres development in the online environment are considered. The history of dialogic formats development is described and the features of their functioning in the online space are highlighted. In particular, the influence of network media on the dialogic formats evolution is noted. In the empirical part, a review of selected YouTube channels is carried out to consider how the dialogic formats features are implemented in the online space. As a result of the study, a general characteristic of dialogic formats evolution in the online space is formulated and the hosting platform influence on the format and content of dialogic genres is identified. The features of the presenter’s role in creating an effective interview, as well as conducting interviews in the online space are considered. In conclusion, the study draws conclusions and offers recommendations for the development of dialogic formats in the online environment. Prospects for further research include conducting a more detailed analysis of dialogic formats evolution in the online space and their impact on the audience.
Evolution of cavity formation in nontuberculosis mycobacteriosis of the lungs
Authors: Amansakhedov R. B. , Makar'yants N. N. , Borisova A. Yu. , Belova U. V. , Lepekha L. N. , Karpina N. L.
Published: November 2023

The results of a long – term observation from practice are presented, which showed the gradual formation of the destruction cavity in a patient with limited focal and peribronchial fibrosis of the lung tissue. Patient H., 54 years old for more than twenty years, was observed by a pulmonologist at the place of residence with a diagnosis of chronic bronchitis with frequent annual exacerbations. She was admitted to the clinic of the FSBSI "CRIT" with complaints of pronounced weakness, fatigue, shortness of breath, prolonged subfebrile temperature mainly at night, cough with difficult-to-separate mucus of a mucous nature. A retrospective analysis of computed tomography of the chest revealed a consistent transformation of local focal peribronchial compaction in the middle lobe of the right lung into a limited area of bronchiectasia and the formation of a small cystic cavity with widespread zones of bilateral pneumonic infiltration. This observation shows the practical significance of CT research in understanding the mechanisms of formation of bronchiectatic cystic cavity in non-tuberculosis mycobacteriosis of the lungs.
Modern approaches to surgical treatment of acute pancreatitis (literature review)
Authors: Chavga A. I. , Midlenko O. V. , Midlenko V. I. , Belonogov N. I. , Khasanova A. Sh. , Zhdanova M. O.
Published: November 2023

Acute pancreatitis, according to different authors, occupies up to 25 % in the structure of emergency surgical pathology of the abdominal organs. Remains quite high postoperative mortality. At present, the search for more effective approaches to determining the tactics of treating such patients and new effective, least traumatic surgical technologies continues. This review has been prepared in order to summarize information of modern approaches to the surgical treatment of acute pancreatitis. The review is based on the study and analysis of sources included in the electronic databases elibrary.ru, cyberleninka.ru and electronic versions of specialized publications that are freely available on the Internet. All authors state the need, along with general clinical studies, to use various methods of abdominal cavity imaging as early as possible. The use of ultrasound, magnetic resonance imaging and computed tomography, including with contrast, is recommended. The use of visualization allows to quickly clarify the diagnosis and choose the best tactics. Currently, most authors prefer percutaneous minimally invasive interventions performed under the control of various imaging methods. A combination of percutaneous and endoscopic technologies is also offered. These techniques allow, in most cases, with high efficiency to reduce the number of complications. Laparotomy has become much less commonly used, however, this access cannot always be refused. The tactics of treatment, including the choice of the method of operation, is carried out depending on the phase of the disease, the location of the focus, its delimitation from the surrounding tissues, the presence of concomitant pathology and complications. Staged surgical treatment with the initial use of minimally invasive techniques is preferred.
Characteristics of lipid metabolism disorders in patients with coronavirus infection-COVID-19 with chronic hepatitis C
Authors: Temnik E. I. , Konstantinov D. Y. , Popova L. L.
Published: November 2023

The aim of the study was to assess individual indicators of lipid metabolism in patients with novel coronavirus infection with chronic hepatitis C (CHC) depending on the severity of COVID-19 and liver fibrosis stage.

Object and methods. A comparative analysis of the results of laboratory examination of patients of the following groups was carried out: group 1 (n = 147) – patients with COVID-19 and CHC, group 2 (n = 81) – patients with COVID-19, group 3 control (n = 94) patients with CHC without COVID-19. In turn, the patients of the first two groups were divided into subgroups according to the severity of the COVID-19: with moderate (A) and severe course (B). According to the liver fibrosis stage, patients with COVID-19 with CHC were divided into 3 subgroups: F1 (mild fibrosis), F2 (moderate fibrosis), F3 (severe fibrosis). In blood serum, lipid profile parameters (total cholesterol (TC), high-density lipoprotein cholesterol (CHDL), low-density lipoprotein cholesterol (CLDL), triglycerides (TG), apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B)) were evaluated. All parameters were assessed in the acute period, according to the severity of COVID-19 and the liver fibrosis stage.

Results. In 100% of patients with COVID-19 and CHC, a decrease in Apo A1 and an increase in Apo B, the ratio of Apo B/Apo A1 were detected, regardless the severity of disease. In patients with severe COVID-19 with CHC, changes in the lipid spectrum were recorded: an increase in TG, Apo AI, Apo B, Apo B/Apo A1 ratio, and a decrease in CHDL, CLDL, Apo A1. In patients with COVID19 and severe liver fibrosis (CHC), a decrease in LDLC, Apo A1 and increase in CLDL, Apo B, ratio Apo B/Apo A1 was observed.
The effect of the A82G mutation in the MMP-12 gene and C634G mutation in the VEGF-A gene on the course of lower limb varicose veins and the risk of disease recurrence
Authors: Yarovenko G. V. , Katorkin S. E. , Komleva Y. M. , Osadchaya P. V.
Published: November 2023

Aim: creation of a method for predicting the development of varicose veins of the lower extremities and its recurrence.

Object and methods. 2 independent studies of patients with C2-C6 varicose veins of the lower extremities (CEAP-classifier) were conducted. In the first, with ultrasound diagnosis of the main veins of the lower extremities and genomic analysis of blood samples, 75 participants (men 20, women 55), mean age 43.7 ± 5.9 years. All patients were randomized into two groups: group I (n = 17) – with recurrent varicose veins; Group II (n = 58) – applied with varicose veins for the first time. The 2nd study involved 44 (men 10, women 34), mean age 55.5 ± 2.7 years. Similarly, patients were divided into groups – I (5) and II (39 people). All patients of the first stage of the study underwent real-time PCR with allele-specific primers to determine the A82G mutation in the MMP-12 gene (matrix metalloproteinase-12) and the second stage C634G in the VEGF-A gene (endothelial fibroblast growth factor – A).

Results of the study. In patients of both groups I and II, having the MMP-12 gene in the heterozygous variant, dilatation of the tibial and popliteal veins was present (6.4 ± 0.3 mm and 10.7 ± 0.24 mm, respectively) with the presence reflux and slowing down the evacuation of blood from the deep venous system. In patients of group I, the MMP-12 gene was found in 80 % of cases, as A/A (homozygous) and A/G (heterozygous variation), while in group II only in 33.3 % of cases. Pearson's goodness-of-fit criterion χ2 = 10.4 (the critical value of the criterion is 6.63), p < 0.01. The frequency of recurrence of varicose veins and mutation of the MMP-12 gene according to the Spearman test was 1.0 with the number of degrees of freedom 23, p < 0.05. In the 2nd study, a correlation was found between groups I and II of patients with the C/C genotype (Pearson's coefficient χ2 = 0.79, p < 0.11) and a correlation in the duration of the disease between groups of patients with the C/C genotype (homozygous variation) and C /G (heterozygous variation) – Pearson correlation coefficient χ2 = 0.92 (p < 0.01).

Conclusion. The revealed relationship between the MMP-12 gene polymorphism and the frequency of varicose vein recurrence is a predictor of the development of structural changes in the vein wall, and a mutation in the VEGF-A gene occurs with a long history of the disease.
Methods of early diagnosis and pharmacological prevention of pancreatitis after endoscopic papillosphincterotomy
Authors: Spiridonov T. R. , Novikova E. D. , El'cov T. O.
Published: November 2023

Introduction. The most frequent complication of endoscopic papillosphincterotomy (EPST) is acute pancreatitis. This complication is supposed to be based on mechanical, chemical, hydrostatic, enzymatic and thermal impact on pancreatic ducts and parenchyma. According to different literature data, the incidence of post-EPST pancreatitis (PEP) varies from 30 to 40 %, and the mortality rate is 2–10 %.

The aim of the investigation was to expand information about peculiarities of early diagnostics and prevention of post-EST pancreatitis at the present stage.

Materials and methods. To reach the set goal we analyzed 559 case histories of patients with diagnosed cholelithiasis, 319 of them underwent EPST.

Results. During the study it was found out, that elevated neutrophils/lymphocytes ratio over 4,96 (p = 0,001), high LDH level over 250 IU/ml (p = 0,01), as well as Creactive to albumin index over 0,180 (p = 0,001) are reliable markers of early diagnosis. Also, indirect diagnostic markers of PEEP are biochemical signs of cholestasis and cytolysis of hepatocytes, as well as hyperglycemia combined with glucosuria. We consider the inclusion of intraoperative injections of papillotomy wound margins with Epinephrine in combination with subsequent Somatostatin administration in combination with rectal Diclofenac and intravenous hydration with Reamberin to be the most effective strategy for PEP prevention.

Conclusions. Thus, we can conclude that despite the ongoing research and the search for effective algorithms for the prevention and early diagnosis of PEP, their data often contradict each other or simply do not confirm their effectiveness. The problem of prevention and diagnosis of PEP remains complex and requires further study. There are discrepancies, sometimes significant ones, in the current literature, which provides grounds for the development and research of new methods of early diagnosis and prevention.
Multiple organ failure in patients with combined breast injury: diagnosis and treatment
Authors: Vladimirova E. S. , Chernousov F. A. , Badygov S. A. , Rey S. I. , Berdnikov G. A. , Klychnikova E. V. , Alekseechkina O. A. , Popova I. E. , Men'shikova E. D.
Published: November 2023

Relevance. Modern methods of diagnosis and treatment of victims with severe combined trauma, the fulfillment of the conditions of the "golden hour" do not solve the problem of a favorable outcome, sepsis and multiple organ failure (PON) remain the main cause of death.

The purpose of the study. To study the possibilities of complex diagnostics and treatment using combined methods of extracorporeal hemocorrection in patients with PON after severe combined breast injury.

Object and methods. The results of diagnosis and treatment of 20 victims with combined chest injury were analyzed. The criteria for inclusion in the study were as follows: age over 18 years; severe combined closed chest injury: AIS > 2 on the background of combined injuries, ISS 28–34 points, severity of the condition on the ARASNE II scale over 20 points, the use of extracorporeal hemocorrection (MEG) methods.

The results of the study. In patients with severe combined breast injury, the severity of the course of multiple organ failure is shown and the effectiveness of combined methods of extracorporeal hemocorrection (MEG), the features of manifestations of PON and the dynamics of changes in indicators against the background of complex treatment is determined. The main method of diagnosis of PON was a clinical and laboratory picture, taking into account coagulological, biochemical disorders, biomarkers of inflammation and instrumental assessment of CT of the lungs and ultrasound picture of the state of parenchymal organs of the chest and abdomen.

Сonclusions. An integrated approach to the management of victims with PON, including early MEG, helps to reduce intoxication, stabilize the condition and increases life expectancy.
Morphological characteristics and diagnostic criteria of traditional serrated adenoma
Authors: Tertychnyy A. S. , Pachuashvili N. V. , Pavlov P. V. , Kiryukhin A. P. , Fedorenko A. A. , Marenich N. S.
Published: November 2023

Traditional serrated adenomas (TSAs) are extremely rare polyps from the group of serrated polyps of the colon. TSAs is no more than 5 % of all colon polyps. A relatively small number of studies have been devoted to this histological variant, at the same time, some aspects of the morphological diagnosis of TSA still remain undisclosed. Purpose: to conduct a clinical and morphological analysis of cases of TSAs.

Materials and methods. The study included 57 cases of TSAs diagnosed in the period from 2021 to 2023. In the cases detected during this period, the results of histological and endoscopic studies were analyzed.

Results. The age of patients ranged from 44 to 78 years and averaged 61.7 years. The ratio of men and women is 1:1.8. Most TSAs were found in the rectum (n = 28) and sigmoid colon (n = 20). In 8 cases, the tumor was localized in the descending part and the splenic flexure of the colon. In 1 observation, a tumor was found in the cecum. The sizes of the polyps ranged from 0.5 cm to 3.5 cm. In 22 cases, the composition of the polyp included tubulovillous adenomas (16 cases) and hyperplastic polyps (6 cases) in addition to TSAs. In 5 cases, foci of highly differentiated adenocarcinoma were detected in the TSAs material.

Conclusion. TSAs has characteristic morphological features with a serrated exophytic growth pattern, cytoplasmic eosinophilia and the presence of ectopic crypts. Due to the difficulties of morphological diagnosis, TSAs in some cases remains undiagnosed. At the same time, due to the increased malignant potential, TSAs requires special vigilance on the part of pathologists and clinicians.
Changes in the hormonal background of medical students in different periods of study, taking into account gender differences
Authors: Maslyakov V. V. , Pavlova O. N. , Habibrakhmanova L. H. , Gilfanov R. R. , Nakaeva E. Y.
Published: November 2023

The purpose of the study. To conduct a study of hormonal changes in medical students in different periods of study, taking into account gender differences.

Object and methods. In order to achieve this goal, a study of the main physiological indicators was conducted in 120 volunteer students aged from up 18 to 24 years. The following criteria were used for inclusion in the studies: the absence of acute or chronic diseases, which is confirmed by the availability of health certificates, the presence of the middle of the menstrual cycle (for women), obtaining consent to conduct the study.

Conclusion. Changes in the hormonal background of medical students depend on gender and the course of study, the greatest changes in the hormonal background of students, 1–2 courses, and these changes occur regardless of gender, then, at 3–4 courses, there is some stabilization of the hormonal background, and this is more concerning for female representatives.
Physiological effects of using a high-protein, low-carbohydrate diet of pregnant and lactating female rats on the development of their offspring
Authors: Makarcheva A. A. , Romanova I. D. , Inyushkina E. M. , Zaynulin R. A.
Published: November 2023

In the modern world, the nature of human nutrition is becoming more relevant. This is due to the spread of diseases such as diabetes mellitus, cardiovascular diseases and metabolic disorders. The health of a person and his offspring comes to the fore. In this regard, high-protein, low-carbohydrate diets are becoming popular at the moment.

The aim of the study was to identify the effect of a high-protein, low-carbohydrate diet of pregnant and lactating female rats on the development of their offspring.

Object and methods. The experiment was carried out on the offspring of female rats. The female rats of the control group received normal nutrition, and for the experimental group a special high-protein, low-carbohydrate diet was compiled, which was maintained throughout pregnancy and in the first week after delivery. As a result of the study, it was revealed that a diet with an increased protein content has a beneficial effect on the development of baby rats in delayed terms: they have a more pronounced weight gain, increased research activity and are less prone to anxiety.
Liver retransplantation in the modern concept of treatment of its terminal pathology (literature review)
Authors: Akhmedov A. R. , Novruzbekov M. S. , Gulyaev V. A. , Olisov O. D. , Lutsyk K. N. , Magomedov K. M. , Kazymov B. I. , Alekberov K. F. , Anosova E. Yu. , Yaremin B. I.
Published: November 2023

The work is devoted to the analysis of modern literature data and approaches in performing repeated liver transplantation. The most frequent causes of liver graft loss are PNFT, HAT, recurrent initial disease and chronic rejection. The leading indication for retransplantation in children is HAT. The one-year survival rate after retransplantation is approximately 75%. Reducing the cost of organ retransplantation and the cost-effectiveness of the procedure are controversial issues. Mathematical modeling has identified several significant recipient and donor factors affecting the outcomes of retransplantation. Despite ethical and economic considerations, retransplantation is the only option for transplant patients whose grafts have failed to engraft. The decision to retransplant should be made with some caution, with full multi-type approach in large multidisciplinary transplant centers.
Emerging epidermal electrodes towards digital health and on-skin digitalization
Authors: Wang Yan
Published: November 2023

Epidermal electrodes can be directly attached to the human skin for high-fidelity electrophysiological monitoring owing to their preponderance in thinness, lightweight, conformability, biocompatibility, self-adhesiveness, mechanical flexibility, gas-permeability, etc . These devices have attracted immense attention due to their emerging applications in personalized health care, human/brain-machine interfaces, and soft robotics. This Perspective focuses on the most recent significant progress in this area, especially materials, properties, and applications. Challenges and prospects are summarized to underscore the unexploited areas and future directions toward digital health and on-skin digitalization.
Organização e disseminação de memórias escolares: uma reflexão sobre a contribuição das bibliotecas para a formação humana integral nos Institutos Federais
Authors: Silva Paula Souza da , Oliveira Ana Paula Lelis Rodrigues de
Published: November 2023

Objetivou-se com esse trabalho, realizar uma reflexão sobre a contribuição das bibliotecas escolares para a formação humana integral dos discentes dos Institutos Federais de Educação, considerando a tríade pesquisa, cultura e trabalho como elementos fundantes. Para isso, foi realizada uma revisão bibliográfica sobre formação integral no contexto da Educação Profissional e Tecnológica, bibliotecas escolares e memórias. Desta forma, pôde-se discutir se e como a organização e a disseminação de memórias escolares podem contribuir para formar discentes mais críticos, emancipados e transformadores de si mesmos e da realidade a que pertencem, e o potencial da biblioteca escolar para criar lugares para essas memórias que sejam espaços não formais de educação a serem utilizados por atividades científicas e culturais através de projetos de ensino, pesquisa e extensão.
Extended Duration Anti-VEGF Therapy for Chorioretinal Vascular Diseases: Successes, Failures and Challenges
Authors: Hasan Azeem , Miller Darby D , Stewart Michael W.
Published: November 2023

Pathologic angiogenesis is responsible for much of the vision loss that stems from several chorioretinal vascular diseases including neovascular age-related macular degeneration (nAMD), diabetic retinopathy (DR), and retinal vein occlusion (RVO). Because vascular endothelial growth factor (VEGF) serves as a pivotal angiogenic molecule, it has emerged as the primary target for therapeutic drugs. Current anti-VEGF therapy is dominated by bevacizumab, ranibizumab, and aflibercept, all of which have been available for more than a decade, but new drugs, both biosimilars (Byooviz and Cimerli) and drugs whose primary aim is to decrease treatment burden (brolucizumab, faricimab, and the ranibizumab port delivery system), have been approved. Recent failures (conbercept, abicipar, and KSI-301) emphasize the complexity of drug development and the difficulties faced by innovators. Most therapies under development, including tyrosine kinase inhibitors and gene therapy, include VEGF-A blockade as their primary function and aim to extend durability rather than increase peak efficacy. But even as many new drugs look to extend durability, cost containment with mandated use of biosimilars serves to balance the therapeutic landscape.
Intellectual Capital of Islamic Boarding Schools to Build Multicultural Education Epistemology
Authors: Futaqi Sauqi , Mashuri Saepudin
Published: November 2023

This research intends to discover the multicultural epistemology at Islamic boarding schools (pesantren). So far, Westerners and some university graduates have dominated the discourse on multicultural education, even though pesantren, with their distinctive intellectual capital, have their own perspectives on understanding, developing, and practicing multicultural education. Using phenomenological qualitative research on two pesantrens in Indonesia, this study uncovered that pesantrens have significant multicultural capital through personal, structural, or relational knowledge. For pesantren, multicultural education is not only an anthropological issue but rather a manifestation of the theology of humanity. Multicultural education for pesantren is a legacy of traditions of freedom of opinion, openness to differences, and the essence of humanity.
Beyond Biontology? Bringing Elizabeth A. Povinelli’s Geontologies to Life-Centred Design
Authors: Meroz Joana
Published: November 2023

The concept of “design for life” has been rapidly picking up steam in the last few years. While the discourse around life-centred design leaves the concept of “life” unproblematised, it uses this term to signify an expansion of the sites and stakeholders of design beyond the human. I therefore define life-centred design as mobilising more-than-human approaches with the explicit aim of intervening in (the debate about) what planetary life is and should become. What purposes might life-centred design fulfil by differentiating between life/nonlife and favouring only the former? This article explores how Elizabeth A. Povinelli’s magisterial Geontologies: A Requiem to Late Liberalism (2016) can contribute to thinking through the ethical implications of life-centred design. I start by discussing three of Geontologies’ key concepts: the carbon imaginary, geontopower, and geontology. I then brief ly experiment with activating those concepts to think about how three life-centred design practices configure life/nonlife and how those configurations might be involved in tactics of control. I then discuss how life-centred design tends to reproduce a modern Western belief in biontology (the equivalence of life with being) and as such risks teproducing (neo-)colonial practices of control. In conclusion, I both consider some of the ethical implications of life-centred design and speculate on those of a hypothetical post-biontological life-centred design.
Design, Semiotics, Anticipation
Authors: Nadin Mihai
Published: November 2023

From the Why semiotics? question to the specific aspects of the semiotic underpinning of design the journey is one of discovery. Indeed, design is discovery, i.e., it is anticipation-driven. Therefore, nothing qualifies as its foundation. Design as a process does not require secure preliminaries (theories) from which to set out. It does not require a “place to stand,” a necessary reference, from which to start the adventure. Design assumptions are by their nature questions guiding anticipatory action. They are circumstances of conf lict (the old, the current, the new), which semiotics registers very much like a seismograph. The “earthquake,” i.e., the creative design, is not the graph of the Earth shaking, but a new landscape. The interruptive character of design inquiry, i.e., its disruptive nature, is especially significant when subjected to the après-design analytic moment. This is when recursive definitions (of aesthetic nature, semiotic, economic, cultural, political, etc. significance) are used as a metric of design, creating the illusion that they can become some norm. Actually, design creates a context for meaningful interactions. Design’s self-motivating nature of inquiry escapes such exercises. The activity called design is constitutive of the new, not the celebration of the past. Therefore, we present not only what has so far been learned from a design informed by semiotics, but also what might better serve designers in the context of the rapid change we experience in our days.
A Method for Evaluating Reservoir Permeability Based on Machine Learning Flow Unit Index
Authors: Cheng Xincai , Zhao Bin , Gao Chuqiao , Gao Ying
Published: November 2023

The H formation of the Y gas field in the X depression belongs to a low-permeability tight sandstone reservoir affected by sedimentation, diagenesis, and cementation. The lithology and pore structure of the target layer are complex, with strong physical heterogeneity and complex pore-permeability relationships. Conventional core pore permeability regression and nuclear magnetic resonance software-defined radio methods do not satisfy the requirements for precise evaluation in terms of permeability calculation accuracy. Based on the principle of the flow zone index (FZI) method, this study analyzed the influence of pore structure on permeability and extracted three pore structure characterization parameters, namely, the maximum pore throat radius (Rmax), displacement pressure (Pd), and average throat radius (R), from the mercury injection capillary pressure curve. The relationship between the FZI and pore structure is clarified. Therefore, the FZI in this area can characterize the permeability differences within different flow units. Based on the flow unit theory, a refined evaluation model for three types of reservoirs was established in the study area. By analyzing the response characteristics and correlation of conventional logging curves using machine learning, three optimization combination curves were selected, and a multiparameter fitting equation for the FZI was established, which was applied to predict the permeability of new wells. The results showed that the calculated permeability was highly consistent with the core analysis results, thereby providing a theoretical basis for the precise evaluation of low-permeability tight reservoirs.
Method for Predicting Transverse Wave Velocity Using a Gated Recurrent Unit Based on Spatiotemporal Attention Mechanism
Authors: Huang Jiaxin , Gao Gang , Li Xiaoming , Li Yonggen , Gui Zhixian
Published: November 2023

Transverse wave velocity plays an important role in seismic exploration and reservoir assessment in the oil and gas industry. Due to the lack of transverse wave velocity data from actual production activities, it is necessary to predict transverse wave velocity based on longitudinal wave velocity and other reservoir parameters. This paper proposes a fusion network based on spatiotemporal attention mechanism and gated recurrent unit (STAGRU) due to the significant correlation between the transverse wave velocity and reservoir parameters in the spatiotemporal domain. In the case of tight sandstone reservoirs in the Junggar Basin, the intersection plot technique is used to select four well logging parameters that are sensitive to transverse wave velocity: longitudinal wave velocity, density, natural gamma, and neutron porosity. The autocorrelation technique is employed to analyze the depth-related correlation of well logging curves. The relationship between the spatiotemporal characteristics of these well logging data and the network attention weights is also examined to validate the rationale behind incorporating the spatiotemporal attention mechanism. Finally, the actual measurement data from multiple wells are utilized to analyze the performance of the training set and test set separately. The results indicate that the predictive accuracy and generalization ability of the proposed STAGRU method are superior to the single-parameter fitting method, multiparameter fitting method, Xu-White model method, GRU network, and 2DCNN-GRU hybrid network. This demonstrates the feasibility of the transverse wave velocity prediction method based on the spatiotemporal attention mechanism in the study of rock physics modeling for tight sandstone reservoirs.
A Long-Lived Accretionary Process during the Amalgamation of the North China Craton: Insights from Neoarchean–Paleoproterozoic Polyphase Magmatism in the Lüliang Complex
Authors: Yu Xinyuan , Zhang Jian , Liu Jin , Yin Changqing , Chen Ying , Guo Minjie , Qian Jiahui , Gao Peng , Cheng Changquan
Published: November 2023

There has been a long debate regarding the timing of the final amalgamation of the North China Craton, which is considered to have occurred either during the Neoarchean or Paleoproterozoic era. One major point of contention is whether there existed a long-lived subduction lasting through the Neoarchean to Paleoproterozoic. The Lüliang Complex contains multiphases of magmatism and thus represents the most viable region to address this controversy. In this study, we carried geochronological and geochemical analysis on the representative granitoids. Secondary ion mass spectrometry U–Pb dating revealed four distinct granitoid groups emplaced at 2531 ± 4, 2189–2173, 2027 ± 25, and 1852 ± 41 Ma, respectively. Notably, the 2531 Ma granitic gneiss was identified for the first time in this region. Based on the geochemical characteristics, the granitoids can be divided into two types. The 2531 and 2027 Ma groups display I-type features, while the 2189–2173 and 1852 Ma groups exhibit A-type geochemical affinities. Both I-type groups exhibit enrichment in Rb, depletion in Nb, Ta, and Ti, moderate fractionated REE patterns, substantial negative Eu anomalies, low Sr/Y ratios, and positive εHf(t) (+3.51 to +5.53 and +5.59 to +7.32, respectively), indicating that they were generated from partial melting of the juvenile mafic crust. In contrast, the 2189–2173 Ma granitoids belong to A2-type and were most likely generated by the partial melting of felsic rocks in the back-arc region, while the 1852 Ma granitoids belong to A1-type and were most possibly the result of partial melting of mafic-intermediate rocks during the post-collisional stage. Based on the records of A-type granitic magmatism and the ~1950 Ma peak metamorphism throughout the Trans-North China Orogen, we propose that a long-lived subduction process (2531–1950 Ma) can mostly explain the existing geological phenomena. It is likely that the subduction between the Eastern and Western Blocks should have commenced at ~2531 Ma, followed by a long-lived subduction. The two blocks ultimately collided with each other to form the North China Craton at ~1950 Ma, which triggered post-collisional exhumation and partial melting at ~1852 Ma.
PhyloBench: a Benchmark for Evaluating Phylogenetic Programs
Authors: Spirin Sergey , Sigorskikh Andrey , Efremov Aleksei , Penzar Dmitry , Karyagina Anna
Published: November 2023

Motivation. Phylogenetic inference based on protein sequence alignment is a widely used procedure. Numerous phylogenetic algorithms have been developed, most of which have many parameters and options. Choosing a program, options, and parameters can be a nontrivial task. No benchmark for comparison of phylogenetic programs on real protein sequences is publicly available.
Results. We have developed PhyloBench, a benchmark for evaluating the quality of phylogenetic inference, and used it to test a number of popular phylogenetic programs. PhyloBench is based on natural, not simulated, protein sequences of orthologous evolutionary domains. The measure of accuracy of an inferred tree is its distance to the corresponding species tree. A number of tree-to-tree distance measures were tested. The most reliable results were obtained using the Robinson–Foulds distance. Our results confirmed recent findings that distance methods are more accurate than maximum likelihood and maximum parsimony. We tested the bayesian program MrBayes on natural protein sequences and found that it is superior to maximum likelihood, but inferior to distance methods. Of the methods we tested, the Balanced Minimum Evolution method implemented in FastME yielded the best results.
Availability. Alignments and reference species trees are available at https://mouse.belozersky.msu.ru/tools/phylobench/ together with a web-interface that allows for a semi-automatic comparison of a user’s method with a number of popular programs.
Taxonomic status and phylogeographical structure in Pseudonereis sp. East Asia in the East China Sea off the Coast of Zhejiang, China
Authors: Chen Yongjiu , Khalfan Zahor Mwalim , Liang Zibin
Published: November 2023

Pseudonereis variegatais a polychaeteous worm (Annelida: Nereididae) with a cosmopolitan distribution in coastal waters; however, noticeable variations in morphology and genetics raised the question whether individuals from distinct ocean basins belong to the same species. This study evaluated the taxonomic status and phylogeographic structure inPseudonereissp. East Asia (asP. variegata) in the East China Sea (ECS) off the Coast of Nanji Islands (NJ) and Zhoushan Islands (ZS), Zhejiang by analyzing a 582bp DNA sequence in mitochondrial cytochrome C oxidase subunit I (COI). A total of 36 haplotypes were scored from 152 specimens, including 40 from ZS and 112 from NJ. Between NJ and ZS, 5 haplotypes were in common. Relatively, the levels of diversity on NJ (Hd = 0.556±0.060, π = 0.149±0.023%) were higher than ZS (Hd = 0.478±0.099, π = 0.110±0.028%). Comparative analyses with morphological characters andCOIsequences of congeneric samples derived from other locations indicated thatPseudonereissp. East Asia in the West Pacific, including the East China Sea/Taiwan Strait (ECS-TS) and Yellow Sea (YS) had a strong and significant divergence from the conspecific specimens in Chile and thus they should be described as a separate species, namelyPseudonereissp. East Asia. The lack of noticeable phylogeographic structuring observed among populations inPseudonereissp. East Asia is probably due to larval transportation and oceanographic connection via the coastal currents. Our study provides basic scientific information for understanding the identity and genetic diversity ofPseudonereissp. East Asia in the East China Sea off the Coast of Zhejiang, China and neighboring areas.
Low MYCT1 expression is an independent prognostic predictor and MYCT1 upregulation can induce oral squamous cell carcinoma development
Authors: Xie Yuanyuan , He Jing , An Wenmin , Li Zhenning
Published: November 2023

Background: MYCT1 is an important candidate marker in several kinds of cancer, but its role in oral squamous cell carcinoma (OSCC) remains unknown. In the study, we aimed to explore the biological role and prognostic value of MYCT1 in OSCC.
Methods: MYCT1 expression was analyzed by using the data from The Cancer Genome Atlas (TCGA) in OSCC. MYCT1 expression in 20 pairs of fresh OSCC tissues and adjacent normal tissues was detected by using quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting respectively. The correlation of MYCT1 protein level in 106 OSCC tissue samples assayed by immunohistochemical staining to overall survival (OS) and disease-free survival (DFS) of the patients was analyzed using the Kaplan-Meier and Cox proportional hazards methods. The effects of MYCT1 on proliferation, migration, invasion, cell cycle and apoptosis of OSCC cells were monitored by cell viability, colony formation, wound healing, transwell invasion and flow cytometry assays, respectively. The prospective MYCT1-related pathways in OSCC were also predicted by bioinformatic analysis.
Results: TCGA data analysis, qRT-PCR, western blot and Immunohistochemistry results showed that MYCT1 expression was significantly decreased in OSCC tissues compared to the controls. Low MYCT1 expression was associated with large size (P = 0.01), advanced pathological grade (P < 0.001), cervical node metastasis (P=0.005) and worse clinical stage (P <0.001) of the tumor tissues, respectively. The Kaplan-Meier and Cox proportional hazards analyses results indicated that low MYCT1 expression was significantly associated with poor overall survival and recurrence-free survival of the patients. Meanwhile, low MYCT1 expression as an independent prognostic factor for the long-term survival of the OSCC patients was also revealed. Contrasted to MYCT1 silence, MYCT1 overexpression significantly repressed the proliferation, migration and invasion, and promoted apoptosis of the OSCC cells. Bioinformatic prediction results demonstrated that MYCT1 might be involved in ECM−receptor interaction, Focal adhesion and PI3K-Akt signaling pathways of the malignant OSCC progress.
Conclusions: MYCT1 plays a suppressor role in OSCC and serves as a prognostic biomarker for the patients of OSCC, which provides a pivotal clue for MYCT1 in diagnosis and therapy of OSCC.
Optochemical profiling of receptor-proximal proteins in vivo in minutes
Authors: Hamachi Itaru , Takato Mikiko , Sakamoto Seiji , Nonaka Hiroshi , Tamura Tomonori
Published: November 2023

Understanding how protein-protein interaction networks in the brain give rise to cognitive functions necessitates their characterization in live animals. However, tools available for this purpose require potentially disruptive genetic modifications and lack the temporal resolution necessary to track rapid changes in vivo. Here, we combined ligand-directed chemistry and photocatalyzed singlet oxygen generation to identify neurotransmitter receptor-proximal proteins in the live mouse brain using only small-molecule reagents and minutes of photoirradiation. Named PhoxID (photooxidation-driven proximity labeling for proteome identification), our method not only recapitulated the known interactomes of two endogenous neurotransmitter receptors (AMPAR and GABAAR) but also uncovered age-dependent shifts, identifying NECTIN3 and IGSF3 as developmentally regulated AMPAR-proximal proteins in the cerebellum. Overall, this work establishes a flexible and generalizable platform to study receptor microenvironments in genetically intact specimens with an unprecedented temporal resolution.
Code-switching in mental health recovery narratives of Hong Kong storytellers
Authors: Ng Stephanie , Zayts-Spence Olga
Published: November 2023

Background
Considering persistently high levels of mental health stigma in Hong Kong in recent years, scholars and mental health professionals alike have demonstrated strong interest in combating this issue. Existing research suggests that recovery storytelling, which involves an individual with a lived experience of mental illness sharing their personal story publicly, is one of the most effective anti-stigma strategies to date.
Methods
Using a narrative inquiry approach, we examined the recovery stories of seven Cantonese-speaking individuals who participated in the More than a Label mental health anti-stigma campaign in Hong Kong. We specifically examined how the discursive strategy of code-switching functioned to clarify, emphasize, or distract from certain elements of the story.
Results
Our analysis demonstrated that code-switching in our data functioned in three distinct ways, namely as: (1) a distancing strategy when discussing troubling past experiences; (2) an authenticating strategy when recalling interactions carried out in English-speaking settings; and (3) a foregrounding strategy to highlighting the main points in the story.
Conclusions
Our study highlights the importance of linguistic research in informing the development of person-centred approaches in both mental health clinical and advocacy work. We suggest that recognizing linguistic behaviours such as code-switching allows mental health clinical and organizational staff to be more sensitive to signs of potential distress and probe further inquiry amongst clients and lived-experience storytellers. We discuss how these findings can be used to educate lived-experience storytellers on the rhetorical functions of language use such as code-switching.
Topological transformation from non-van der Waals solids to 2D transition metal chalcogenides in molten salts with solvated metals
Authors: Li Mian , Gao Lin , Liang Kun , Huang Qing
Published: November 2023

Transition metal chalcogenides (TMCs) have attracted great attention due to their wide range of applications. The TMCs have been widely synthesized using techniques such as exfoliation and vapor-phase growth, while their structure and constituent tuning remains a challenge. Here, we show a general route to synthesize 2D TMCs by topological transformation of AMX2-type ternary metal chalcogenides in molten salts with solvated metals. In this process, the solvated metals in the molten salts play a role of etchant that can remove the A-layer atoms from the AMX2 structure, resulting in the formation of laminated MX2 layers. The laminated MX2 layers provide natural template for cations intercalation or atom substitution to form 2D TMCs with various structures. In the present work, 2D TMCs with tunable stoichiometries (e.g. Cr2S3, Cr3S4, Cr5S6, and Cr7S8), as well as 2D TMCs with heterostructures (e.g. Cr2S3-Ti0.5CrS2, Cr2S3-NbS2, and Cr2S3-HfS2) were obtained. We further explored the potential of this route to tail the dielectric properties and improve the electromagnetic wave absorption ability of the chromium sulfides. This approach shows advantage in exploring 2D structures with unprecedented constituent and we believe it will open up opportunities for tuning the properties and broaden the functional applications of TMCs.