bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial Prediction Method for Digital Soil Mapping
Authors: Chen Lixia , Lv Hui
Published: November 2024

The spatial distribution of soil information is the basic data required for ecological hydrological simulation, global change research, and resource and environmental management. Digital soil mapping (DSM) is an efficient way to obtain and express soil spatial distribution information. This paper introduces the theories and principles of DSM, compares the principles, characteristics, and applicable conditions of spatial prediction methods widely used in DSM, and proposes a selection strategy for spatial prediction methods for DSM, which provides a reference for the promotion of DSM.
The Relationship Between Emotional Eating and Depression: Intervention Strategies and Future Research Directions
Authors: Yuan Yunqi
Published: November 2024

Abstract: In recent years, emotional eating, defined as the act of consuming food as a means of coping with negative emotions, has garnered significant attention from the psychological community. As such, the paper examines the intricate relationship between emotional eating and depression. Through a review of the existing literature, emotional eating is explored as a potential trigger and exacerbator of depressive symptoms, especially when individuals use food as a coping mechanism for negative emotions. Besides, it discusses the psychological mechanisms behind emotional eating, including difficulties in emotion regulation and the use of inadequate coping strategies, highlighting the particular significance of these factors in depressed patients. The paper evaluates the efficacy of current interventions for reducing emotional eating and alleviating depressive symptoms, with a particular emphasis on the potential that cognitive behavioral therapy (CBT), dialectical behavioral therapy (DBT), and positive thinking interventions have demonstrated in improving emotion regulation and reducing the impact of negative emotions on eating behavior. The analysis of the efficacy of these psychotherapeutic approaches in practice presents a theoretical foundation for future intervention strategies and supports the design of more targeted treatment plans in clinical practice, so as to assist depressed patients in improving their mood regulation and reducing the frequency of emotional eating, thereby enhancing their quality of life.
Analysis of Cultural Differences in Chinese and English Food Advertising Language
Authors: Mao Kexin
Published: November 2024

Abstract: This research explores the cultural differences in Chinese and English advertising languages, with a particular focus on food advertisements. In the context of globalization, understanding how cultural values shape advertising strategies is crucial for effective cross-cultural communication. Advertisements not only reflect the product being promoted but also embody the cultural norms and consumer expectations of their target audience. The study aims to investigate the linguistic features, cultural values, and persuasive strategies embedded in food advertisements, comparing the differences between Chinese and English contexts. The research employs a content analysis method, examining a total of 100 food advertisements, with 50 from Chinese markets and 50 from English-speaking markets. Both linguistic and semiotic elements, including persuasive language, imagery, and cultural symbols, are analyzed. Functionalist translation theory serves as the main analytical framework, as it emphasizes the role of cultural context in shaping meaning and the communicative purpose of the advertisements. The results reveal significant differences in the use of persuasive language, cultural symbols, and rhetorical devices. For instance, Chinese advertisements often emphasize collective values and tradition, while English advertisements lean towards individualism and innovation. These findings suggest that advertisers and translators need to adopt tailored approaches when targeting different cultural markets. By recognizing and adapting to cultural norms, advertisers can create more resonant and effective campaigns in cross-cultural environments.
The Possibility of Peace Between Israel and Palestine
Authors: Chou Hung-Tsung
Published: November 2024

Abstract: This passage basically illustrates about the origin of the conflict between Israel and Palestine. By using the historical evidence to evaluate the possibility of peace between those two countries inside middle east. Palestinians and Israelis, Arabs and Jews, have been in a state of constant dispute since 1947, when the United Nations issued a decision on the distribution of land in the Palestinian territories. It may seem that peace is a distant aspiration for this region. At the beginning of this article, we will analyze the ancient Middle East and the history of these two peoples. Quite a lot of causes come from history. We're going to delve into the history from 1947 to the present and look at what happened in the modern era that led these two countries into an ongoing war. Finally, this paper will using the data and contemporary event to discover the possibility of success negotiate of peace.
The Influence of College Students Spoken-English Self-esteem on IELTS Speaking Performance under the Social Comparison Theory
Authors: Wu Yuxin
Published: November 2024

Abstract: Nowadays, the Chinese IELTS speaking level is lower than that of other modules, such as reading, writing, and listening. It can be improved by expanding the way of learning spoken English through TikTok's app. The group of College students is a key time when the ideological concept is gradually mature and gradually know themselves, and learning spoken English in this software environment may produce the psychological behaviour of social comparison, it may produce spoken-English low self-esteem and affect the IELTS speaking performance. In order to study the impact of spoken-English low self-esteem on IELTS speaking performance, this paper will understand the basic theories through the existing research literature on Social Comparison Theory, the emotion of foreign language learning, academic performance and so on, and summarize the reasons for social comparison in real learning life. A conclusion that from the social and academic dimensions, college students are compared with different users through this short video interaction and push function, and self-cognitive bias leads to spoken-English low self-esteem, which positively or negatively affects attention, pressure, social willingness and self-confidence by affecting learning efficiency and motivation, resulting in a positive or negative correlation between IELTS performance and oral low self-esteem. The purpose of this paper is to extend the research on the foreign language learning emotions and IELTS-specific modules and to provide reasonable learning suggestions for college students learning IELTS speaking in an online environment.
Animal models: A powerful tool for the study of human diseases
Authors: Ai Chen
Published: November 2024

Abstract. The application of animal models is an alternative approach to studying human diseases and developing new drugs without direct trials on humans due to ethical and technical restrictions. The animal model is a widely used approach to study human metabolic diseases since humans and animals share a high similarity of biological and physiological features. With the development of genetic engineering technology, its application has evolved to simulate human diseases in animals as human wills. This paper summarized the literature concerning animal models to provide an overview of the course of animal models application, the selection criteria of animal species and the limitations of their application. It can be concluded that animal models, at present, should mainly serve as a medical tool to provide clinical recommendations for the treatment of human diseases and new drug development as there are nonnegligible biological, financial and ethical problems associated with the application of animal models, for instance, different intolerance of chemicals, low input conversion efficiency, and animal welfare considerations.
Contemporary strategies and challenges in the management of acute Leukemia: An in-depth analysis
Authors: Zhou Shengnan
Published: November 2024

Abstract. This article provides a detailed overview of the current state of acute leukemia treatment, encompassing chemotherapy, molecular-targeted therapy, bone marrow transplantation, and the evolving role of personalized medicine. It delves into standard chemotherapy regimens, their efficacy, and adverse effects, highlighting the challenges posed by resistance and relapses. The significant impact of molecular-targeted therapy, including tyrosine kinase inhibitors and FLT3 inhibitors, is examined, along with their integration with traditional chemotherapy. The article also discusses bone marrow transplantation, comparing allogeneic and autologous transplants and conditioning regimens. Personalized medicine, driven by genetic profiling and the emergence of novel therapies like CAR-T and immunomodulatory drugs, is explored for its potential to revolutionize treatment approaches. The global trends in acute leukemia, including epidemiological shifts and disparities in access to care, are analyzed, alongside the economic aspects influencing treatment accessibility and policy decisions. This comprehensive review underscores the multifaceted nature of acute leukemia treatment and the ongoing efforts to enhance patient outcomes while addressing global disparities in care.
Application of fat substitutes in meat products
Authors: Yang Lin
Published: November 2024

Abstract. In the human body, fat plays a key role. In addition to providing the body with the necessary energy, it also has a decisive influence on the structure and overall quality of food. However, frequent intake of high-fat food will have adverse effects on human health. With the increase in people's health awareness, the production of low-fat or fat-free food is an important way to improve people's dietary habits and improve their health levels. Therefore, it is hoped that by adding fat substitutes, we can reduce the harmful effects of excessive fat intake on the human body while maintaining the original flavor of food as much as possible. In this paper, the research reviews the basic concepts and classification of fat substitutes and their application in meat products, the current status of their application in sausage, pork, beef, and other products is elaborated, and the problems of fat substitutes such as intolerance to high-temperature frying are analyzed, and countermeasures for the research and development of fat substitutes with high thermal stability, high water absorption, low calorie content, and nutritional safety are proposed, providing provide a theoretical basis for the further development and utilization of fat substitutes in meat products.
Study on the potential construction of giant virus gene transfer vectors
Authors: Li Chengxuan
Published: November 2024

Abstract. In 2003, a unique virus parasitic to amoebic protozoa was first isolated from water in a cooling tower in the United Kingdom . This virus possesses numerous characteristics that distinguish it from conventional viruses. Owing to its substantial genome capacity and physical volume, such viruses have been labeled as giant viruses. Due to their relatively recent discovery, limited existing research impedes the realization of their practical applications. Given their potential to carry extensive genetic information, this paper asserts the potential of these viruses to be fashioned into specialized virus transfer vectors and deliberates upon this topic. This study synthesizes domestic and international research on large viruses, analyzing their structural characteristics and host properties to explore the feasibility of constructing large virus transfer vectors. Large viruses possess traits not inherent in traditional viral vectors, such as the ability to survive in extremely short environments and accommodate vast genetic capacities. As a novel research domain in the past two decades, further exploration of the types, structural characteristics, and host properties of large viruses is necessary to ascertain their potential in constructing gene transfer vectors.
Interrogating pathophysiological processes: A multidisciplinary perspective on medical biochemistry and molecular biology
Authors: Liu Yi
Published: November 2024

Abstract. This study offers a comprehensive exploration into the intricate world of medical biochemistry and molecular biology, highlighting key molecular mechanisms and their implications in health and disease. Through quantitative analysis and mathematical modeling, we dissect various biochemical pathways, gene expression regulation, and protein functions, aiming to elucidate their roles in cellular processes and medical conditions. The investigation encompasses a multifaceted approach, integrating data from genomic studies, proteomics, and bioinformatics tools to offer insights into the molecular underpinnings of diseases, potentially paving the way for novel therapeutic strategies.
Pathogenesis and treatment of Alzheimers disease
Authors: Pan Jiahui
Published: November 2024

Abstract. Alzheimers disease (AD) is a degenerative disease which was first discovered in 1907, it has been a far-reaching disease difficult to cure. Hundreds of millions of people have been plaguing AD. The high incidence rate and high death rate of AD has brought tremendous burden to country and society. Human has made significant achievement in pathobiology so far. This article first makes a brief introduction about the history of AD, and the clinical presentation of AD patients. Besides that, some issues may be neglected. Hypotheses about the pathogenicity and new treatment policy of AD have been mentioned in this essay, providing effective remedy of AD, such as primary neuropathologic criteria, amyloid positron emission tomography imaging and targeted therapies. This thesis introduces AD by doing a literature review anlysis. The critical essay summarizes the main body of academic papers, evaluates academic articles in specific fields. But it may also face the problem of what to discuss in a literature review.
A novel approach to breast cancer Assessing the promise of RF16662 on MCF-7 breast cancer cells
Authors: Lu Yancheng
Published: November 2024

Abstract. Breast cancer, a prevalent global health issue, often poses challenges due to resistance apoptosis. This study explores the potential of RF16662, a derivative of naphthyridine, as a novel compound for breast cancer treatment. Naphthyridine compounds, known for inducing necroptosis in cancer cells, offer a unique avenue for addressing apoptosis-resistant cancers. RF16662s efficacy was evaluated through three experiments on MCF-7 breast cancer cells. The MTT cell viability assay demonstrated a strong negative correlation between RF16662 concentration and cell viability, indicating its effectiveness in inhibiting MCF-7 cellular activity. DNA fragmentation analysis revealed substantial DNA fragmentation in cells treated with RF16662, suggesting necroptosis induction. MLKL immunofluorescence confirmed the significant difference in relative MLKL expression between untreated and treated cells, further supporting the induction of necroptosis. This study provides robust evidence of RF16662s efficacy against MCF-7 breast cancer cells. However, variations in MLKL immunofluorescence data suggest the need for repeated experiments to minimize the standard deviation. The results highlight RF16662s potential as an anti-breast cancer drug, offering a promising avenue for future research and potential therapeutic development. While its efficacy against other cancer types remains unknown, RF16662 emerges as a noteworthy candidate in the ongoing quest for innovative breast cancer treatments.
Research on the application of micro-robotics in the drug delivery field
Authors: Lei Siqi
Published: November 2024

Abstract. Drug delivery has been one of the hotspots of research in the field of pharmacy. Delivering drugs to the target location more accurately and efficiently is a problem that researchers have been thinking of facing. The invention of the microrobot has led to greater convenience in the field of micromanipulation. Microrobots have demonstrated exceptional promise and significant benefits in the field of medication delivery in recent years, owing to their versatility, low invasiveness, and controllability. This paper comprehensively reviews the research on microrobots for drug delivery applications. First, we summarize the microrobots in vivo motion technology from the propulsion mode perspective and discuss its effects. Subsequently, we analyze the new technologies in the field related to microrobots used for drug-targeting applications and explore the release method of the drug to reach the target location. Finally, synthesizing the analysis results, we give the problems and future development of microrobot applications in the field of drug delivery.
Review on the development of the organoids
Authors: Zuo Jiapeng
Published: November 2024

Abstract. Organoids, a novel field, were first experimentally supported in 2007 and began to be engineered around 2020. Organoids can be developed from stem cells or organ progenitor cells through the process of differentiation, or they can be created by changing the alignment of pluripotent stem cells throughout the process of cell differentiation. Organoids are exploited for the purpose of scientific research in the areas of human development, illness, screening of medications, and gene therapy. The study utilized a literature review method to examine the evolution of organoid production, new application, and technological advancements. Organoids have advanced from basic tissue engineering organs to being used for modeling diseases and providing more therapeutic options. Their progress is noteworthy and has the potential to be a significant approach in biological medicine research in the future.
The application of statistical techniques in assessing the impact of medical interventions: A case study of diabetes management
Authors: Feng Haoxi
Published: November 2024

Abstract. Medical intervention encompasses a range of strategies, such as drug therapy, surgical procedures, and lifestyle modifications, aimed at enhancing the patients health or preventing diseases. The objective of assessing the efficacy of medical interventions is to determine whether these interventions are efficacious, safe, cost-effective, and ethical. Statistical methods serve as vital tools for evaluating the impacts of medical interventions, facilitating the development of rational research protocols, data collection and analysis, trustworthy conclusions, and the promotion and implementation of findings. This paper examines the application of four statistical methods in evaluating the effects of medical interventions using diabetes management as a case study. The analysis reveals that randomized controlled trials, meta-analyses, and causal inference all contribute to enhancing the reliability of assessment, while propensity score matching enhances the quality of matching. However, the drawback of randomized controlled trials is their substantial demand for subjects, time, resources, and personnel, making it challenging to generalize their findings to real-world clinical and social contexts. Causal inference may encounter issues such as randomization failure during implementation. Propensity score matching necessitates the selection of an appropriate propensity score model and matching method, which can impact the effectiveness and efficiency of the matching process.
The study on the preparation of new drugs targeting the pathogenesis and related influencing factors of Alzheimer's disease
Authors: Zhou Ziyu
Published: November 2024

Abstract. With the development of society, Alzheimers disease has gradually become an important issue in the world health system. However, after a long period of research, the pathogenic factors and mechanisms of Alzheimers disease are still unclear, which has a serious impact on an increasing number of elderly people. So drug research for Alzheimers disease is particularly urgent. This article takes Alzheimers disease as the background, and proposes constructive treatment suggestions and potential targets by studying the impact mechanisms of some substances. The article consists of four parts: Amyloid Precursor Protein, Brain-Gut Axis , the Curcumin, and Glycogen Synthase Kinase 3 Inhibitors. By exploring each mechanism of action, this paper predicts its therapeutic methods and targets in Alzheimers disease. Through analysis, it is believed that in the future, although people may still not be able to completely cure Alzheimers disease, we can better transform it into a chronic disease. Updating the original diagnostic methods for blood and cerebrospinal fluid can improve the cure rate and enable early detection and treatment.
Perspectives and insights on physical therapy's function in COVID-19 rehabilitation
Authors: Hui Zhilin
Published: November 2024

Abstract. Physical treatment is useful in reducing the many COVID-19 problems, according to recent studies. The significance of physical therapy in the all-encompassing management of the new coronavirus has been brought to light. Physical therapy is the main body of rehabilitation therapy, including a wide range of techniques (such as sound, light, cold, heat, electricity, force (movement and pressure) and other physical factors for treatment, as well as breathing, muscle training, for local or systemic body dysfunction or lesions, The use of non-invasive, non-drug treatment, reinforcement strategy exercises, immediate relief of symptoms and overall improvement of the patients physical function and restoration of the patients original body physiological function. This integrated approach enables patients to return to their previous level of activity and quality of life by highlighting the entire context of treatment. Physiotherapy is not without its limitations, though. Physiotherapy requires patient-specific care, because there arent enough doctors or patients during a pandemic. To ensure the provision of effective rehabilitation services, creative solutions are required to address issues including the shortage of specialists, the requirement for training units, and the return of telemedicine. Furthermore, further research efforts and interdisciplinary collaboration are required to establish effective practices and improve patient outcomes related to physical therapy engagement in COVID-19 recovery programs. As a result, the pandemic has brought attention to and strengthened an important shift in the role of physical therapy in the management of post-viral syndromes, opening the door for future advancements in the field of infectious disease medicine.
Research on the influencing factors of type 2 diabetes
Authors: Zheng Ru
Published: November 2024

Abstract. Type 2 diabetes has become a serious chronic disease, which poses a great threat to human health. In previous research, the author found that people at higher risk for type 2 diabetes had unchanged characteristics - family history, age, having diabetes during pregnancy and being overweight at birth. Additionally, there are many reasons why people develop type 2 diabetes, such as weight, physical activity, blood pressure, cholesterol levels, smoking, diet, alcohol, stress and health, and sleep. However, with the development of technology in recent years, the influencing factors may have changed. This study mainly collected and analyzed examples of 768 women, including 8 variables such as pregnancy, glucose and so on. The target variable is whether the woman has type 2 diabetes. In this study, the accuracy of both the testing and training model is in a good state at 77%, so the binary logistic regression is acceptable. In order to better understand the influencing factors of type 2 diabetes, more comprehensive data support and more advanced analysis are needed. This model sets the stage for the factors that influence type 2 diabetes in women.
Research on the mechanism of DTL in the occurrence and development of cancer
Authors: Yue Shutong , Fang Yong
Published: November 2024

Abstract. DTL (denticleless E3 ubiquitin protein ligase homolog) is an E3 ubiquitin ligase that is highly expressed in a variety of tumors and is closely related to the occurrence and development of tumors. Here, we review the latest progress in DTL regulation in various cancer data, including the mechanisms by which changes in its expression affect multiple pathways, ultimately leading to cell cycle arrest and tumor proliferation. Future research should further elucidate the molecular mechanism of DTL and its relationship with tumorigenesis, which is of great significance for the prevention, diagnosis and treatment of tumors. In addition, multi-omics data need to be used to further explore the differential expression and regulatory network of DTL at the single cell level, which is crucial for finding tumor suppressor drug targets.
5-HT2AR and its implication on anti-depression therapy development
Authors: Chen Yixi
Published: November 2024

Abstract. Major depression disorder (MDD) affects a big population and causes disability and productivity loss worldwide. Yet, fast-onset, powerful cure with minor side effects is scant. Therefore, there is an urging need to examine the biological bases for MDD treatment to design novel antidepressants. The serotonin system in the brain has long been a hot spot for research in this field, leading to accumulating biochemical discoveries of specific serotonin receptors. In this review, we briefly summarized the serotonin hypothesis of MDD, then focused on the implication of serotonin 2A receptor (5-HT2AR) in MDD therapy. Latest genomic evidence of 5-HT2AR gene variations related to MDD was presented. 5-HT2AR antagonists and agonists with antidepressive effects and their possible mechanisms of action was discussed. Based on current understanding of the 5-HT2ARs involvement in MDD therapy, we enumerated several future directions for developing applicable 5-HT2AR-targeting MDD treatment.
Magnetic hexagram micro soft robot
Authors: Qian Fiona
Published: November 2024

Abstract. This research focuses on the development of a hexagram-shaped multimodal magnetic soft robot for biomedical applications. This micro-robot utilizes principles of soft robotics and magnetic control mechanisms to achieve precise manipulation and maneuverability within biological environments at the micrometer to millimeter scale. Its advantages include precise navigation through physiological fluids via magnetic fields, enabling targeted drug delivery, diagnostic imaging enhancement, and minimally invasive surgical interventions. The hexagram shape ensures stable and controlled movements, overcoming instability seen in alternative robotic systems. However, these magnetic robots also face challenges such as size constraints, navigating turbulent flows and anatomical obstacles, sustaining operations with an efficient energy source, and biocompatibility concerns.
The common component of traditional Chinese medicine formulations has a role in the treatment of hypertension.
Authors: Liu Shiqi
Published: November 2024

Abstract. Hypertension is one of the most common cardiovascular diseases, but the control rate of hypertension is not high, only 16.8%, which a serious public health problem in our country. This article analyzes some commonly used traditional Chinese medicine formulations that effectively treat high blood pressure and lists the ingredients of these common drugs. Find common ingredients that includes: Rhizoma Gastrodiae, Uncaria, and Licorice. The study found that the active ingredients in the three herbs, such as gastrodin, gastrodia elata ethyl acetate extract routine and isoglycyrrhizin, have a significant effect on lowering blood pressure. This research can provide hypertensive patients with a better understanding of the reasons for taking these herbs and offer guidance on medication. It can also help patients recognize the necessity of combined Chinese medicine. However, the study only explore the blood pressure-lowering effects of the active ingredients but does not investigate the specific treatment of different types of hypertension using individual Chinese medicine preparations. In the future will refine the effects of these herbs in various types of hypertension.
Mechanistic analysis of NK cells in pan-cancer tumor immunity
Authors: Song Jialin
Published: November 2024

Abstract. Chimeric antigen receptor (CAR) NK cell therapy has been hampered in solid tumors by an incomplete understanding of tumor-infiltrating NK cells. Based on the development of single-cell sequencing methods, this paper used single-cell sequencing data of NK cells from the GEO database to cluster them, focused on the CD56brightCD16lo-CREM subpopulation, which was statistically screened for differential genes and investigated its gene pathways. The results showed that this subpopulation can provide energy for tumor proliferation by promoting ribosomal autophagy, and at the same time express cell adhesion molecules, cytokines and related proteins to interact with monocytes and macrophages, hindering the function of NK cells and promoting tumor progression. This provides new ideas for in-depth analysis of the immunological role of NK cells in pan-cancer tumors.
Imaging processing settings of bright field staining images
Authors: Fu Yishan
Published: November 2024

Abstract. Background: Clear images are vital to studying the cells and exploring the relationships between different parts of cells. Thus, histology is important to view the microscopic structures of cells by using different colors to show. However, the pipeline of getting a better and more useful image of bright field staining images is still a challenge. This article introduces different processed images to get a good condition to improve image quality. Methods: Four staining ways, including Periodic acidSchiff (PAS) staining, Hematoxylin and Eosin (H&E) staining, Trichrome Staining, and immunohistochemistry (IHC), have been used on the liver, heart, and brain sections. Photoshop and Image J were used to process images of different conditions. The software settings have been compared. Results: 60X Oil immersion can provide nice details for the liver, heart, and brain with PAS, Trichrome, and H&E staining. By comparing different settings on software, the following settings can be optimal options: 300 PPI resolution for optimal size and clarity, gamma to adjust the light and dark, color balance to make the colors more comfortable to the eye, TIFF format to meet most requirements. Image J, compared to Photoshop, can solve many image processing and analysis problems with a smaller installation package and is free to download. Conclusions: By using optimized settings of image software, researchers can get better pictures and assist in solving more scientific problems.
Application of ketogenic diet in the treatment of diseases
Authors: Huang Sirui
Published: November 2024

Abstract. The ketogenic diet (KD) has gained recognition for its unique dietary composition that focuses on high fat, low carbohydrate, and moderate protein intake. Originally developed as a treatment for refractory epilepsy, the KD has expanded its applications to address a variety of health conditions, including obesity, diabetes, cancer, and even novel coronavirus pneumonia (COVID-19). This review delves deeply into existing literature to uncover the historical origins of KD, shed light on the complexities of ketogenic metabolism, and summarize the therapeutic benefits of KD in various diseases along with its mechanisms. In addition to exploring the positive aspects of KD, this study meticulously scrutinizes the potential short- and long-term adverse reactions and contraindications associated with the diet. Furthermore, strategic recommendations are proposed to optimize the outcomes of KD therapy. By offering a comprehensive analysis, this review endeavors to furnish valuable theoretical foundations that can elevate the clinical implementation of the KD in medical practice.
Vaccine Therapies for Cancer: Challenges and Strategies
Authors: Miao Zhanxi
Published: November 2024

Abstract. As oncology vaccines have become more effective in clinical trials, it has become clear that they have great potential to attack malignant tumors in the future. Even though oncology vaccines are now a minor success and most of the cancer vaccines in the market are prophylactic rather than therapeutic for malignant tumors, cancer vaccines are still in the limelight and a lot of research has been invested in this area. From the time that tumor vaccines were noticed and researched to the present day, they have always faced difficulties, which has led to no breakthrough in cancer vaccines for a long time. Nowadays, only a small percentage of cancer vaccines have been put into clinical use despite the tireless efforts of people. There is still a lot of room for progress in cancer vaccines, and this paper goes through the development, types, and mechanisms of cancer vaccines to understand the advantages and disadvantages of cancer vaccines and analyze the challenges and strategies of cancer vaccines.
The connection of COVID-19 infection rate to a healthy diet
Authors: Tong Yujun
Published: November 2024

Abstract. In today's post-epidemic era, small-scale infections occur from time to time. While more research is focused on tackling COVID-19, before finding a way to eliminate its threat, it's even more important that ordinary people take simple steps to reduce their chances of getting infected in their daily lives. This paper focuses on the relationship between the infection rate of COVID-19 and diet and tries to find a nutrient intake way for people to prevent them from being infected by COVID-19. Through the analysis of the database, the Chi-square test, and the linear and logistical relationship between the infection rate and various nutrient intake ways are obtained. By eliminating the effects of obesity and undernourished rate, by analyzing nutrient intake ways, vegetal and animal products are two major parts of nutrient intake ways, and they are considered able to provide better resistance to infection. For more specific components, milk, meats, and cereals are beneficial for the resistance of infection.
Performance comparison of logistic regression and random forest model in bipolar disorder diagnosis
Authors: Zhong Ruowei
Published: November 2024

Abstract. Bipolar disorder (BD) is a significant psychiatric disease that has a large impact on patients living qualities. The diagnosis of BD is important for the early treatment and effective control that benefits the patients, their families, and society. With the development of machine learning algorithms, this paper makes use of the multinomial logistic regression (LR) and Random Forest (RF) models in predicting bipolar disorder (BD). The evaluation and comparison between the two models are conducted to present the possibility of using ML models to help with diagnosis of the BD. A dataset consisting of 120 individuals, including 28 BD Type I patients, 31 BD Type II patients, 31 depression patients, and 30 normal individuals was used in this study. The performance of the models was assessed using metrics such as accuracy, confusion matrix, cross-validation scores, classification report, and ROC-AUC curves. The multinomial LR model demonstrated superior performance with an accuracy of 83%, higher cross-validation scores, and better discriminative ability as indicated by ROC-AUC values. In contrast, the RF model achieved an accuracy of 79%, with lower precision and recall for certain classes. The findings suggest that the multinomial LR model is more effective in predicting bipolar disorder and its subtypes, making it a robust and reliable tool for clinical diagnostics.
A comprehensive analysis of diabetes risk factors: Effects of gender, region, and lifestyle
Authors: Zhu Lidong
Published: November 2024

Abstract. The prevention and nursing of diabetes is one of the research hotspots in the medical field. Diabetes is a prevalent illness that can seriously harm a patient's health if prompt, efficient prevention and treatment are not received. Studying diabetes nursing and prevention is crucial as a result. Many theories about the causative elements of diabetes are held by the medical community. For instance, obesity has a major role in the onset of diabetes. This paper will conduct a detailed statistical analysis of publicly available diabetes datasets, descriptive statistics, chi-square tests, and a series of regression analyses for factors such as total cholesterol, high-density lipoprotein, blood pressure, and gender to determine whether these are key predictors of diabetes. Diabetes was found to be substantially correlated with obesity, high cholesterol, and the high density lipoprotein (HDL) values. The study's findings offer a crucial statistical foundation for the treatment and avoidance of diabetes.
Neuropathogenesis of tic disorders in children and adolescents
Authors: Bi Yu
Published: November 2024

Abstract. Tics disorder (TD) is a chronic neuropsychiatric disease typified by recurrent involuntary tics, speech, or behavioral abnormalities. Different populations are at risk of developing this disease, and it can pose serious physical harm. For example, TD can cause learning difficulties, make patients isolated, and have anti-social psychological and conduct disorders, which seriously affects their normal life. To this end, how to treat or prevent this disease is particularly important. Studying the pathogenesis of TD can be beneficial for developing more effective treatment methods. The study of the pathogenesis of TD is related to the onset and progression of the disease, and it can play a role in diagnosing and treating it. This research will discuss neurobiochemical factors, neuroimmune factors, and neuroanatomical factors, and summarizes the neural mechanism of TD. A thorough analysis of these mechanisms is beneficial for a better understanding of this disease, and it can provide effective strategies for prevention and intervention.
Unveiling the dominant influence: genetic status and lifestyle factors in cardiovascular health
Authors: Liu Jingyi
Published: November 2024

Abstract. Cardiovascular disease (CVD) is a leading cause of death globally, with a profound impact on public health worldwide. Nevertheless, the dominant risk factor of CVD is still not established. Developing customized therapies and preventative measures for CVD requires an understanding of the interaction between inherited genetic variables and lifestyle choices. This study aims to investigate whether genetic status or acquired lifestyle factors predominantly influence the prevalence of CVD, using a dataset of over 400,000 adults. Through chi-square tests and logistic regression, the study analyses the association between genetic health, lifestyle habits, and the occurrence of CVD. The results reveal that both genetic health and lifestyle choices significantly impact CVD, with smoking showing the most substantial influence. This research underscores the importance of addressing lifestyle behaviors, especially smoking, as a key factor in managing and preventing cardiovascular disease. This study adds to the understanding of how genetics and lifestyle together influence cardiovascular disease risk.
The reasons and solutions for lipsotrichia and pelada phenomenon
Authors: Wang Yantong
Published: November 2024

Abstract. According to Darwins evolution, people know that humans evolved from certain types of apes which used to have a lot of hair. In the process of evolving from apes to humans, apes hair was lost gradually. Nowadays, there is only a little bit of hair that modern humans still left, like hair on the heads and four limbs. NLM database reported an experiment that justified hair on the heads can protect human brains by reducing solar radiation. But many people, because of some reasons, like genes, immune system, and endocrine, have hair loss problems, which leads to possible damage to their brain and appearance. This paper aims to explore the way to mitigate scarring alopecia and androgenetic alopecia. The results show that people can prevent their hair by changing their life habits cleaning their scalps carefully and having a good mood. If they already get scarring alopecia, people must take medicine based on medical advice. And if people get androgenetic alopecia, they should use Minoxidil. This paper can help people with hair loss problems grow their hair back so that it can better help the brain dissipate heat.
Research progress on treatments for Alzheimer's disease
Authors: Ma Yishan
Published: November 2024

Abstract. Alzheimers disease (AD) is an irreversible neurological degenerative disease characterized by progressive cognitive impairment, and its pathogenesis remains unclear. Its main pathological features include neurofibrillary tangles formed by hyperphosphorylated tau protein and amyloid beta (A) plaque deposition. As the disease progresses, the patients self-care ability will become worse and worse. In the later stages, the patient will have to rely on others for daily life, which places a great burden on the patient, family, and society. Currently, there are a limited number of AD treatment drugs and their efficacy is limited, and they cannot effectively improve the condition of AD. This article reviews different methods for treating AD and provides a reference for the treatment of AD. At present, the treatment of senile dementia is mainly divided into two categories. The current treatment methods include Lencamab, bee therapy related drugs, NSCs transplantation therapy, Panax notoginseng saponins, and hyperbaric oxygen therapy. It is necessary to explore new treatment methods and drugs to improve treatment effectiveness and widely apply dementia in the elderly.
Predication on organs-on-chips applications the systematic treatment of breast cancer
Authors: Wang Xueyan
Published: November 2024

Abstract. With the continuous development of cancer therapy, traditional in vitro models have been unable to reproduce the structure of organs and tissues of various parts of the human body, fluid flow and mechanical stimulation characteristics, and the human tumor microenvironment, which is crucial to the study of the behavior and progress of cancer, can not be presented through the animal model in vivo, which shows that the traditional physiological model of cancer can no longer meet the research of human anti-cancer therapy. Benefits from the continuous infusion of cell cultures through the microchannel, the device of organ-on-a-chip improves cell viability and activity and facilitates the simulation of the tumor cell microenvironment, which is expected to further replace traditional zoological experiments. This study reviews a method to simulate the microenvironment of the vitro breast cancer metastasis combined with microfluidic technology, and the application of this device in relevant researches of breast cancer cell metastasis and screening of breast cancer therapeutics.
Association between circadian gene expression amplitude and phase abnormalities and ocular diseases
Authors: Huicong Zheng , Jian Zhang , Tianyu Yang
Published: November 2024

Abstract. The biological clock is an internal timing regulation system that exists in almost all organisms, including humans. It plays an important regulatory role in the physiology, behavior, and cognitive functions of organisms. It is one of the important mechanisms for organisms to adapt to the environment, maintain a stable internal environment, and achieve coordination of biological functions. The master controller of the biological clock system is located in the suprachiasmatic nucleus of the brain. Normal operation of the biological clock requires the normal expression of clock genes such as Bmal1 and Cry. Clock and rhythm genes also exist in the retina. Damage to the retinal clock can affect the occurrence and development of retinal diseases and also have an impact on retinal aging. This article reviews the relationship between myopia, diabetic retinopathy, glaucoma, age-related macular degeneration, and abnormalities in clock genes, providing new ideas for the management and treatment of these diseases in clinical practice.
Characteristics and neural mechanisms of active forgetting in patients with PTSD
Authors: Li Ziyu
Published: November 2024

Abstract. The intrusive thoughts and memory function disorders caused by PTSD have a negative impact on the lives of patients, and the neural mechanism of active amnesia is not yet fully understood. This study aims to explore the characteristics and neural mechanisms of active forgetting in PTSD patients. By studying the characteristics of directed forgetting and suppression-induced forgetting in PTSD patients, as well as understanding and analysing relevant paradigms, behavioural evidence and neural evidence, we finally found that the mechanism of directed forgetting and suppression-induced forgetting in PTSD patients are different. That is, the directional amnesia effect of patients with high-level PTSD is higher than that of patients with low-level PTSD, while the suppression-induced forgetting effect of patients with high-level PTSD is lower than that of patients with low-level PTSD. The reason is that patients with high-level PTSD have a strong sense of self-protection, so they actively avoid emotional materials during the encoding stage of memory, resulting in selective encoding of emotional materials. Therefore, the directed forgetting effect is strong. Individuals with high levels of PTSD have a weakened ability to inhibit emotional material, leading to their inability to stop involuntarily ruminating on it, and thus their suppression-induced forgetting effect is weak. Overall, this study understands the key factors that are beneficial to the recovery of PTSD patients, and at the same time provides certain reference and guidance for the treatment plan of PTSD patients.
Hydrogel dressing in diabetic wound healing
Authors: Huang Yueming , Li Shanruya
Published: November 2024

Abstract. With the intensification of social ageing, the number of geriatric patients continues to increase. Among them, the problem of diabetic patients whose wounds cannot heal for a long time and even cause amputation has received widespread attention. Excessive inflammation caused by adverse exogenous and endogenous factors that interfere with the regulation of wound inflammation is the main factor in the failure of the wound to heal according to standard procedures. As a polymer with a three-dimensional structure, the hydrogel is expected to be a new type of chronic wound dressing with good potential due to its good biocompatibility and drug loading. Summarizing the advantages of new functional hydrogel dressings and the progress of research in diabetic wounds, it is expected to provide some new ideas for clinical research and functional improvement of hydrogels.
Research progress of photodynamic therapy in antitumor therapies
Authors: Zhang Junyu
Published: November 2024

Abstract. As one of the leading causes of disease death globally, conventional treatments for cancers have been developed, including surgery, chemotherapy, radiotherapy etc. However, some drawbacks restrain their therapeutic effects. Consequently, researchers have been struggling to develop novel strategies to cure tumors. Photodynamic therapy (PDT) is a significant means that utilizes light as well as photosensitizers to kill tumor cells. In PDT, a photosensitizer absorbs a photon and transfer to states with higher energy, then energy is released and generates free radicals and ground-state molecular oxygen by two distinct types of reaction to exert therapeutic functions. This review concentrates on the antitumor principles and mechanisms of PDT, common photosensitizers, combination of PDT and other cancer therapies and its effects on several typical cancers.