bluuebunny/crossref_metadata_2025 huggingface dataset:
Propionibacterium freudenreichii Inhibits RANKL-Induced Osteoclast Differentiation and Ameliorates Rheumatoid Arthritis in Collagen-Induced Arthritis Mice
Authors: Yeom Jiah , Yim Dong Joon , Ma Seongho , Lim Young-Hee
Published: December 2021

Osteoclast differentiation is crucial for bone absorption, and osteoclasts are involved in bone destruction in rheumatoid arthritis (RA). Dairy Propionibacterium freudenreichii is used as a cheese starter and possesses prebiotic and postbiotic properties. It is known to stimulate the growth of bifidobacteria and produces valuable metabolites, such as vitamin B12 and propionic acid. However, limited information is available on the beneficial effects of P. freudenreichii on human disease. Herein, we aimed to investigate the inhibitory effect of P. freudenreichii MJ2 (MJ2) isolated from raw milk on osteoclast differentiation and evaluate the improvement in RA. The murine macrophage cell line, RAW 264.7, and a collagen-induced arthritis (CIA) mouse model were used to perform in vitro and in vivo studies, respectively. Heat-killed P. freudenreichii MJ2 (hkMJ2)-treated cells significantly inhibited RANKL-induced osteoclast differentiation and TRAP activity. HkMJ2-treated cells exhibited significantly decreased expression of genes and proteins related to RANKL-induced osteoclast differentiation. MJ2 administration decreased the arthritic score in the CIA mouse model. Live and dead MJ2 inhibited bone loss and afforded protection against bone erosion and joint damage in CIA mice. MJ2 decreased the levels of collagen-specific antibodies and inflammatory cytokines and the expression of osteoclast differentiation-related genes and proteins in CIA mice. Interestingly, live and dead MJ2 showed similar RA improvement effects in CIA mice. In conclusion, P. freudenreichii MJ2 inhibited osteoclast differentiation by inhibiting the NF-κB signaling pathway and ameliorated CIA.
Reply to Pavlik et al. Clinical Relevance and Environmental Prevalence of Mycobacterium fortuitum Group Members. Comment on “Mugetti et al. Gene Sequencing and Phylogenetic Analysis: Powerful Tools for an Improved Diagnosis of Fish Mycobacteriosis Caused by Mycobacterium fortuitum Group Members. Microorganisms 2021, 9, 797”
Authors: Mugetti Davide , Tomasoni Mattia , Pastorino Paolo , Esposito Giuseppe , Menconi Vasco , Dondo Alessandro , Prearo Marino
Published: December 2021

We appreciate the valuable comment of Pavlik et al. [...]
Radiation-Induced Oxidation Reactions of 2-Selenouracil in Aqueous Solutions: Comparison with Sulfur Analog of Uracil
Authors: Skotnicki Konrad , Janik Ireneusz , Sadowska Klaudia , Leszczynska Grazyna , Bobrowski Krzysztof
Published: December 2021

One-electron oxidation of 2-selenouracil (2-SeU) by hydroxyl (●OH) and azide (●N3) radicals leads to various primary reactive intermediates. Their optical absorption spectra and kinetic characteristics were studied by pulse radiolysis with UV-vis spectrophotometric and conductivity detection and by the density functional theory (DFT) method. The transient absorption spectra recorded in the reactions of ●OH with 2-SeU are dominated by an absorption band with an λmax = 440 nm, the intensity of which depends on the concentration of 2-SeU and pH. Based on the combination of conductometric and DFT studies, the transient absorption band observed both at low and high concentrations of 2-SeU was assigned to the dimeric 2c-3e Se-Se-bonded radical in neutral form (2●). The dimeric radical (2●) is formed in the reaction of a selenyl-type radical (6●) with 2-SeU, and both radicals are in equilibrium with Keq = 1.3 × 104 M−1 at pH 4 (below the pKa of 2-SeU). Similar equilibrium with Keq = 4.4 × 103 M−1 was determined for pH 10 (above the pKa of 2-SeU), which admittedly involves the same radical (6●) but with a dimeric 2c-3e Se-Se bonded radical in anionic form (2●−). In turn, at the lowest concentration of 2-SeU (0.05 mM) and pH 10, the transient absorption spectrum is dominated by an absorption band with an λmax = 390 nm, which was assigned to the ●OH adduct to the double bond at C5 carbon atom (3●) based on DFT calculations. Similar spectral and kinetic features were also observed during the ●N3-induced oxidation of 2-SeU. In principle, our results mostly revealed similarities in one-electron oxidation pathways of 2-SeU and 2-thiouracil (2-TU). The major difference concerns the stability of dimeric radicals with a 2c-3e chalcogen-chalcogen bond in favor of 2-SeU.
Investigation of the Optical Properties of a Novel Class of Quinoline Derivatives and Their Random Laser Properties Using ZnO Nanoparticles
Authors: Almansour Abdulrahman I. , Arumugam Natarajan , Prasad Saradh , Kumar Raju Suresh , Alsalhi Mohamad S. , Alkaltham Manal Fahad , Al-Tamimi Haya bint Abdulaziz
Published: December 2021

Quinoline Schiff bases display potential applications in optoelectronics and laser fields because of their unique optical properties that arise from extensive delocalization of the electron cloud, and a high order of non-linearity. In this context, a new class of conjugated quinoline-derivative viz. N-(quinolin-3-ylmethylene)anilines were synthesized from 2-hydroxyquinoline-3-carbaldehyde in two good yielding steps. The ability of these imines to accept an electron from a donor is denoted by their electron acceptor number and sites, which is calculated using density functional theory (DFT). The optical properties such as FT-IR, Raman, UV-VIS, and EDS spectra were calculated using TD-DFT, which also provided the energy gap, HOMO-LUMO structure. The optical properties of the synthesized imino quinolines were experimentally studied using photoluminescence and absorption spectroscopy. The properties such as Stokes shift and quantum yield were calculated using experimental data. Furthermore, the compound bearing a methyl group on the aryl ring and ZnO nanoparticles (hydrothermally synthesized) were dissolved in toluene, and optically excited with a 355 nm nanosecond laser, which produced a random laser.
Metal Complexes or Chelators with ROS Regulation Capacity: Promising Candidates for Cancer Treatment
Authors: Li Xiang , Wang Yuhui , Li Man , Wang Huipeng , Dong Xiongwei
Published: December 2021

Reactive oxygen species (ROS) are rapidly eliminated and reproduced in organisms, and they always play important roles in various biological functions and abnormal pathological processes. Evaluated ROS have frequently been observed in various cancers to activate multiple pro-tumorigenic signaling pathways and induce the survival and proliferation of cancer cells. Hydrogen peroxide (H2O2) and superoxide anion (O2•−) are the most important redox signaling agents in cancer cells, the homeostasis of which is maintained by dozens of growth factors, cytokines, and antioxidant enzymes. Therefore, antioxidant enzymes tend to have higher activity levels to maintain the homeostasis of ROS in cancer cells. Effective intervention in the ROS homeostasis of cancer cells by chelating agents or metal complexes has already developed into an important anti-cancer strategy. We can inhibit the activity of antioxidant enzymes using chelators or metal complexes; on the other hand, we can also use metal complexes to directly regulate the level of ROS in cancer cells via mitochondria. In this review, metal complexes or chelators with ROS regulation capacity and with anti-cancer applications are collectively and comprehensively analyzed, which is beneficial for the development of the next generation of inorganic anti-cancer drugs based on ROS regulation. We expect that this review will provide a new perspective to develop novel inorganic reagents for killing cancer cells and, further, as candidates or clinical drugs.
In Vitro Evaluation of the Anti-Diabetic Potential of Aqueous Acetone Helichrysum petiolare Extract (AAHPE) with Molecular Docking Relevance in Diabetes Mellitus
Authors: Akinyede Kolajo Adedamola , Oyewusi Habeebat Adekilekun , Hughes Gail Denise , Ekpo Okobi Eko , Oguntibeju Oluwafemi Omoniyi
Published: December 2021

Diabetes mellitus (DM) is a chronic metabolic condition that can lead to significant complications and a high fatality rate worldwide. Efforts are ramping up to find and develop novel α-glucosidase and α-amylase inhibitors that are both effective and potentially safe. Traditional methodologies are being replaced with new techniques that are less complicated and less time demanding; yet, both the experimental and computational strategies are viable and complementary in drug discovery and development. As a result, this study was conducted to investigate the in vitro anti-diabetic potential of aqueous acetone Helichrysum petiolare and B.L Burtt extract (AAHPE) using a 2-NBDG, 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl) amino)-2-deoxy-d-glucose uptake assay. In addition, we performed molecular docking of the flavonoid constituents identified and quantified by liquid chromatography-mass spectrometry (LC-MS) from AAHPE with the potential to serve as effective and safe α-amylase and α-glucosidase inhibitors, which are important in drug discovery and development. The results showed that AAHPE is a potential inhibitor of both α-amylase and α-glucosidase, with IC50 values of 46.50 ± 6.17 (µg/mL) and 37.81 ± 5.15 (µg/mL), respectively. This is demonstrated by a significant increase in the glucose uptake activity percentage in a concentration-dependent manner compared to the control, with the highest AAHPE concentration of 75 µg/mL of glucose uptake activity being higher than metformin, a standard anti-diabetic drug, in the insulin-resistant HepG2 cell line. The molecular docking results displayed that the constituents strongly bind α-amylase and α-glucosidase while achieving better binding affinities that ranged from ΔG = −7.2 to −9.6 kcal/mol (compared with acarbose ΔG = −6.1 kcal/mol) for α-amylase, and ΔG = −7.3 to −9.0 kcal/mol (compared with acarbose ΔG = −6.3 kcal/mol) for α-glucosidase. This study revealed the potential use of the H. petiolare plant extract and its phytochemicals, which could be explored to develop potent and safe α-amylase and α-glucosidase inhibitors to treat postprandial glycemic levels in diabetic patients.
A Lactic Acid Bacteria Consortium Impacted the Content of Casein-Derived Biopeptides in Dried Fresh Cheese
Authors: Novak Jasna , Butorac Katarina , Leboš Pavunc Andreja , Banić Martina , Butorac Ana , Lepur Adriana , Oršolić Nada , Tonković Katarina , Bendelja Krešo , Čuljak Nina , Lovrić Marija , Šušković Jagoda , Kos Blaženka
Published: December 2021

This study aimed to define a consortium of lactic acid bacteria (LAB) that will bring added value to dried fresh cheese through specific probiotic properties and the synthesis of bioactive peptides (biopeptides). The designed LAB consortium consisted of three Lactobacillus strains: S-layer carrying Levilactobacillus brevis D6, exopolysaccharides producing Limosilactobacillus fermentum D12 and plantaricin expressing Lactiplantibacillus plantarum D13, and one Enterococcus strain, Enterococcus faecium ZGZA7-10. Chosen autochthonous LAB strains exhibited efficient adherence to the Caco-2 cell line and impacted faecal microbiota biodiversity. The cheese produced by the LAB consortium showed better physicochemical, textural and sensory properties than the cheese produced by a commercial starter culture. Liquid chromatography coupled with matrix-assisted laser desorption/ionization-time of flight tandem mass spectrometry (LC-MALDI-TOF/TOF) showed the presence of 18 specific biopeptides in dried fresh cheeses. Their identification and relative quantification was confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) using multiple reaction monitoring (MRM). The results also showed that their synthesis resulted mainly from β-casein and also α-S1 casein degradation by proteolytic activities of the LAB consortium. The designed LAB consortium enhanced the functional value of the final product through impact on biopeptide concentrations and specific probiotic properties.
The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage
Authors: Mosca Rodrigo Crespo , Santos Sofia Nascimento , Nogueira Gesse Eduardo Calvo , Pereira Daisa Lima , Costa Francielli Campos , Pereira Jonathas Xavier , Zeituni Carlos Alberto , Arany Praveen Ravindra
Published: December 2021

The increased precision, efficacy, and safety of radiation brachytherapy has tremendously improved its popularity in cancer care. However, an unfortunate side effect of this therapy involves localized skin damage and breakdown that are managed palliatively currently. This study was motivated by prior reports on the efficacy of photobiomodulation (PBM) therapy in improving tissue resilience and wound healing. We evaluated the efficacy of PBM therapy on 36 athymic mice with 125I seed (0.42 mCi) implantation over 60 days. PBM treatments were performed with either red (660 nm) or near-infrared (880 nm, NIR) LEDs irradiance of 40 mW/cm2, continuous wave, fluence of 20 J/cm2 once per week. Animals were evaluated every 7 days with digital imaging, laser Doppler flowmetry, thermal imaging, µPET-CT imaging using 18F-FDG, and histology. We observed that both PBM treatments—red and NIR—demonstrated significantly less incidence and severity and improved healing with skin radionecrosis. Radiation exposed tissues had improved functional parameters such as vascular perfusion, reduced inflammation, and metabolic derangement following PBM therapy. Histological analysis confirmed these observations with minimal damage and resolution in tissues exposed to radiation. To our knowledge, this is the first report on the successful use of PBM therapy for brachytherapy. The results from this study support future mechanistic lab studies and controlled human clinical studies to utilize this innovative therapy in managing side effects from radiation cancer treatments.
Discrete Element Simulation on Sand-Bed Collision Considering Surface Moisture Content
Authors: Dun Hongchao , Yue Peng , Huang Ning , Zhang Jie
Published: December 2021

The process of aeolian sand transport is an important mechanism leading to the formation and evolution of local landforms in coastal areas and desert lakes. For a long time, the role of surface moisture in incipient motion of sand grains by wind stress has been extensively studied but, in fact, sand-bed collision is the main mechanism in steady aeolian sand flow. At present, the lack of understanding of surface moisture content on sand-bed collision limits the application of aeolian sand transport models in wet coastal areas. In this paper, we adopt numerical simulations to discuss and analyze the effect of cohesive forces formed by surface moisture content on the sand-bed collision process based on discrete element method. High density contact forces appear with the surface moisture increasing, and form a closed structure around the edge of crater to resist the avulsion in horizontal direction. Under high moisture condition, even though the ejected sand grains saltate away from the surface, the tension forces will prevent from leaving. The ejected number trend with incident velocity shows some nonlinear characteristics due to the unequally distributed force chains and liquid bridges in the unsaturated sand bed surface.
Oxidation of Monoethylene Glycol to Glycolic Acid with Gold-Based Catalyst and Glycolic Acid Isolation by Electrodialysis
Authors: Tschirner Sarah , Weingart Eric , Teevs Linda , Prüße Ulf
Published: December 2021

In this work, a highly selective and active gold-based catalyst for the oxidation of high concentrated monoethylene glycol (MEG) in aqueous solution (3 M, 20 wt%) is described. High glycolic acid (GA) selectivity was achieved under mild reaction conditions. The optimization of the catalyst composition and of the reaction conditions for the oxidation of MEG in semi-batch mode under alkaline conditions led to a GA yield of >80% with a GA selectivity of about 90% in short reaction time. The bimetallic catalyst 0.1 wt% AuPt (9:1)/CeO2 showed very high activity (>2000 mmolMEG/gmetalmin) in the oxidation of MEG and, contrary to other studies, an extremely high educt to metal mole ratio of >25,000 was used. Additionally, the gold–platinum catalyst showed a high GA selectivity over more than 10 runs. A very efficient and highly selective process for the GA production from MEG under industrial relevant reaction conditions was established. In order to obtain a GA solution with high purity for the subsequent polymerization, the received reaction solution containing sodium glycolate, unreacted MEG and sodium oxalate is purified by a novel down-stream process via electrodialysis. The overall GA yield of the process exceeds 90% as unreacted MEG can be recycled.
A Unique Case of the Transformation of a Hepatic Leiomyoma into Leiomyosarcoma with Pancreatic Metastases: Review of the Literature with Case Presentation
Authors: Colagrande Anna , Cazzato Gerardo , Fedele Salvatore , Andriola Valeria , Ingravallo Giuseppe , Resta Leonardo , Vincenti Leonardo
Published: December 2021

Primary hepatic leiomyoma (PHL) is a rare entity, with very few cases reported in the literature. Even more rarely, until now practically undescribed, is the transformation of a hepatic leiomyoma into leiomyosarcoma with pancreatic metastases. Here, we report a single case of the progression of PHL in primary hepatic leiomyosarcoma, with clinical–surgical and histopathological features, and we conducted a review of the literature of related cases that can be found.
AHP–TOPSIS Methodology for Stock Portfolio Investments
Authors: Vásquez Jaime Alberto , Escobar John Willmer , Manotas Diego Fernando
Published: December 2021

This paper presents a methodology for making decisions in the stock market using the AHP-TOPSIS multi-criteria technique. The problem is related to the stock market’s investment process considering the criteria of liquidity, risk, and profitability. The proposed methodology includes integrating economic and financial theories of investment in equity portfolios with the AHP-TOPSIS multi-criteria technique, which allows for evaluating a finite number of alternatives hierarchically under qualitative and quantitative criteria. The methodology has been tested in a real case of selecting a portfolio of high and medium marketability stocks for the Colombian market from April 2012 to April 2017. The computational results show the importance and efficiency of successfully integrating traditional equity portfolio investment criteria and multi-criteria methodologies to find an appropriate balance between profitability and risk in the investment decision-making process in shares in the Colombian stock market. The proposed methodology could be applied to other emerging markets, similar to Colombia.
Cause-Related Marketing and Ethnocentrism: The Moderating Effects of Geographic Scope and Perceived Economic Threat
Authors: Boulouta Ioanna , Manika Danae
Published: December 2021

Amongst the various factors that managers need to consider when designing a CRM campaign is the cause’s geographic scope, i.e., should the CRM campaign benefit local, national, or international communities? Although previous research has examined the importance of geographic scope in the effectiveness of the CRM campaigns, it has largely ignored consumer reactions to CRM campaigns from a local cultural identity perspective, such as ethnocentric identity. This study brings together these two important factors to examine (through the lens of Social Identity Theory) how consumer ethnocentrism affects CRM effectiveness in campaigns varying in geographic scope. We test our hypotheses through an experimental study of 322 British consumers and three different geographic scopes (UK, Greece, and Ethiopia). Our results show that ethnocentric consumers show a positive bias towards products advertised through national CRM campaigns; however, there is a diversity of reactions towards different international geographic scopes, based on the levels of ‘perceived economic threat’. Ethnocentric consumers prefer international CRM campaigns that benefit people located in a country posing a lower vs. a higher economic threat to the domestic economy and the self. Our study contributes to a broader understanding of factors affecting the effectiveness of CRM campaigns and help managers design better CRM campaigns by carefully selecting the geographic scope, after considering a rising consumer segment: the ethnocentric consumer.
Modelling of Auxetic Woven Structures for Composite Reinforcement
Authors: Shukla Shivangi , Behera Bijoya Kumar , Mishra Rajesh Kumar , Tichý Martin , Kolář Viktor , Müller Miroslav
Published: December 2021

The current research is focused on the design and development of auxetic woven structures. Finite element analysis based on computational modeling and prediction of axial strain as well as Poisson’s ratio was carried out. Further, an analytical model was used to calculate the same parameters by a foldable zig-zag geometry. In the analytical model, Poisson’s ratio is based on the crimp percentage, bending modulus, yarn spacing, and coefficient of friction. In this yarn, properties and fabric parameters were also considered. Experimental samples were evaluated for the actual performance of the defined auxetic material. Auxetic fabric was developed with foldable strips created in a zig-zag way in the vertical (warp) direction. It is based on the principle that when the fabric is stretched, the unfolding of the folds takes place, leading to an increase in transverse dimensions. Both the analytical and computational models gave close predictions to the experimental results. The fabric with foldable strips created in a zig-zag way in the vertical (warp) direction produced negative Poisson’s ratio (NPR), up to 8.7% of axial strain, and a maximum Poisson’s ratio of −0.41 produced at an axial strain of around 1%. The error percentage in the analytical model was 37.14% for the experimental results. The computational results also predict the Poisson’s ratio with an error percentage of 22.26%. Such predictions are useful for estimating the performance of auxetic woven structures in composite reinforcement. The auxetic structure exhibits remarkable stress-strain behavior in the longitudinal as well as transverse directions. This performance is useful for energy absorption in composite reinforcement.
The Emission of VOCs and CO from Heated Tobacco Products, Electronic Cigarettes, and Conventional Cigarettes, and Their Health Risk
Authors: Lu Fengju , Yu Miao , Chen Chaoxian , Liu Lijun , Zhao Peng , Shen Boxiong , Sun Ran
Published: December 2021

The differences in aerosol composition between new tobacco types (heated tobacco products and electronic cigarettes) and conventional cigarettes have not been systematically studied. In this study, the emissions of volatile organic compounds (VOCs), carbon monoxide (CO), nicotine, and tar from heated tobacco products (HTPs), electronic cigarettes (e-cigarettes) and conventional cigarettes were compared, and their health risks were evaluated by applying the same smoking regime and a loss mechanism of smoking. Twenty VOCs were identified in aerosols from HTPs, 18 VOCs were identified in aerosols from e-cigarettes, and 97 VOCs were identified in aerosols from cigarettes by GC–MS and HPLC analysis. The concentrations of total VOCs (TVOCs) emitted by the three types of tobacco products decreased as follows: e-cigarettes (795.4 mg/100 puffs) > cigarettes (83.29 mg/100 puffs) > HTPs (15.65 mg/100 puffs). The nicotine content was 24.63 ± 2.25 mg/100 puffs for e-cigarettes, 22.94 ± 0.03 mg/100 puffs for cigarettes, and 8.817 ± 0.500 mg/100 puffs for HTPs. When using cigarettes of the same brand, the mass concentrations of VOCs, tar, and CO emitted by HTPs were approximately 81.2%, 95.9%, and 97.5%, respectively, lower than the amounts emitted by cigarettes. The health risk results demonstrated that the noncarcinogenic risk of the three types of tobacco products decreased as follows: cigarettes (3609.05) > HTPs (2449.70) > acceptable level (1) > e-cigarettes (0.91). The lifetime cancer risk (LCR) decreased as follows: cigarettes (2.99 × 10−4) > HTPs (9.92 × 10−5) > e-cigarettes (4.80 × 10−5) > acceptable level (10−6). In general, HTPs and e-cigarettes were less harmful than cigarettes when the emission of VOCs and CO was considered.
Basic Mechanisms for Developing State Strategic Planning in the Russian Federation
Authors:   State University of Management, Mishin Yurii V. , Mishin Aleksandr Yu. ,   Financial University under the Government of Russian Federation
Published: December 2021

In modern conditions, implementation of sustainable progressive movement of the country by carrying out large-scale structural changes can be realized only on the basis of a centralized identification of areas, goals, priorities of socio-economic development, as well as indicators of strategies, programs and plans interconnected at all levels of the country's national economy management. Methodologically the article is based on dialectical method of scientific knowledge, as well as systemic and institutional approaches. Scientific periodicals (monographs, scientific articles, etc.) and official documents of legislative and executive authorities of the Russian Federation on the issues of state strategic and long-term planning in Russia and the USSR were used as an information and analytical base. The article dwells on the following issues: 1) as a result of analysis of domestic and foreign literary sources, as well as regulatory and methodological guidelines in the field of state strategic planning, its main shortcomings were identified. According to the authors, these include: dissemination of program-targeted management methods not only into all spheres of socio-economic development, but also to the areas of budget allocations, the lack of sufficient information base of calculations; 2) methodological approach (stages, sequence of work, methods and procedures) to elaborating state programs for the economic development of the country, industries and regions is proposed; 3) application of the methods of hierarchies analysis (MHA) and network modeling (NPM) as the main methods for developing state programs is substantiated; 4) proposals on the composition and structure of the information base for calculating indicators of state programs are given.
Концепция ситуационно-стратегического планирования потребления природного газа на промышленном предприятии
Authors:   Российский государственный университет нефти и газа (НИУ) имени И.М. Губкина, Киршина Ирина Артуровна ,   Уральский федеральный университет имени первого Президента России Б.Н. Ельцина, Кокшаров Владимир Алексеевич ,   Уральский федеральный университет имени первого Президента России Б.Н. Ельцина,   Уральский государственный университет путей сообщения
Published: December 2021

В научной статье рассмотрена концепция ситуационно – стратегического планирования потребления природного газа на промышленном предприятии, основанная на двух матричных моделях: ситуационная модель планирования стратегий энергоэффективности и энергосбережения и выбор стратегического использования технологий, ситуационная модель планирования стратегий потребления энергоресурсов в топливно-энергетическом балансе. Взаимосвязь этих моделей позволяет формировать матрицу мониторинга основных показателей характеристик, обеспечивающих реализацию энергоэффективной стратегии потребления природного газа, предполагающая целый ряд характеристик, оптимизируя которые можно обеспечивать качество планирования и управления ситуационно – стратегическим потреблением природного газа в системе топливно-энергетического баланса промышленного предприятия.
Проблемы развития Северного морского пути и его инфраструктуры в условиях спада экономической активности
Authors:   Северо-Западный институт управления - филиал Российской Академии народного хозяйства и государственной службы при Президенте РФ, Бабкина Людмила Николаевна , Скотаренко Оксана Вячеславовна ,   Мурманский Арктический государственный университет,   Военная академия материально-технического обеспечения имени генерала армии А.В. Хрулева, Смирнов Алексей Юрьевич ,   Санкт-Петербургский государственный морской технический университет, Хаценко Егор Сергеевич ,   Комитет молодежной политики Мурманской области
Published: December 2021

В статье отмечается, что развитие Северного морского пути и прилегающих к нему территорий Арктической зоны Российской Федерации является необходимым условием повышения конкурентоспосбности национальной экономики в долгосрочной перспективе, позволяя использовать природные ресурсы, не вовлеченные в хозяйственный оборот. Выявляются негативные экономические тренды, ставшие следствием спада экономической активности, вследствие эпидемии коронавирусной инфекции, которые существенным образом влияют на результативность реализуемых инвестиционных проектов в сфере добычи полезных ископаемых в Арктической зоне. Предлагается уточнить и скорректировать существующие прогнозы перевозки грузов по Северному морскому пути, обеспечить максимально эффективное использование ресурсов федерального бюджета на развитие его инфраструктуры. Используя методы сравнительного анализа и системного подхода, авторы делают выводы о том, что в условиях спада экономической активности объем перевозки грузов частными компаниями по Северному морскому пути к 2024 г. будет находиться в диапазоне 47-50 млн тонн, а ряд намеченных проектов в сфере добычи полезных ископаемых реализованы не будут. Даются рекомендации по корректировке существующих планов по развитию инфраструктуры Северного морского пути (включая строительство атомных ледоколов) с целью более эффективного использования средств федерального бюджета.
The Status of English in Morocco: Lessons from Spontaneous Debates in Social Media
Authors: Bouziane Abdelmajid , Saoudi Mohamed
Published: December 2021

Morocco, a multilingual country with historical and geo-political legacies, has opened a hot debate on languages recently. Within this debate, this article investigates spontaneous comments in social media on languages in Morocco, especially adopting English as a first foreign language. It aims to bring this topic to the surface and thus discuss it in the light of research on language attitudes and language awareness. To do so, it analyses the reactions to texts about the declarations by the Minister of Higher Education shared in social networks and sites. The data consisting of 2,018 comments is classified according to 12 frequent patterns whose frequencies are calculated. The findings show that most of Moroccans have positive attitudes towards English while some show opposing reactions towards French. These participants hold ambivalent opinions about the rest of languages used in Morocco; however, they tend to insist on Morocco having a clear language policy which, seemingly, prioritises the mother tongues, Arabic and Amazigh. The discussions show that some investigated reactions are mitigated as they may be illusionary.
'My Name to me a Sadness Wears': Self and Other According to 'Diary by E. B. B.'
Authors: Rowland Yana
Published: December 2021

This paper dwells on the issue of selfhood in Elizabeth Barrett Browning’s Diary (1831 – 1832). It explores individuation against three major presences in the poetess’s life: her father (and family), Hugh Stuart Boyd, and literature. The employed strategy of research includes a phenomenological (interspersed with feminist touches) focus on select excerpts from the Diary which reveal the writer’s concern for Self as the recognition of the priority of a precursory Other. Observations are made on the limits of human perception, time and space as human variables, the ontological essence of interpretation, and memory as a premise for cognizing life as care. A rare example of prose-fiction in the poetess’s oeuvre, her diary could be read as an instance of simultaneous self-nullification and self-affirmation, which offers possibilities for a dialectical definition of female genius as dialogue through narrative.
Síndrome neuroléptico maligno. Presentación de un caso y revisión de la literatura
Authors: Colón Núñez Solangel , López Santacruz Yenis Angélica , Brito Hernández Alberto
Published: December 2021

El Síndrome Neuroléptico Maligno (SNM), es una peculiar y peligrosa complicación del tratamiento con fármacos antipsicóticos, que se caracteriza por fiebre, rigidez muscular severa y cambios en el estado autonómico y mental. Se realizó una revisión de los aspectos epidemiológicos, fisiopa- tológicos, diagnósticos y enfoques terapéuticos siguiendo una investigación cualitativa descriptiva con  triangulación  de información,  resultado  del  análisis  de  la  historia  clínica,  del  seguimiento  y evolución del caso en la terapia intensiva y apoyada en la revisión de la literatura científica, sobre esta patología. Se presenta el caso clínico de un paciente con el SNM, después de la medicación con antipsicóticos, del tipo haloperidol, asociado a la administración de metoclopramida y que por sus complicaciones, presentó arritmias cardiacas, trastornos del medio interno y trombosis venosa profunda del miembro inferior izquierdo, lo que necesitó el ingreso en la unidad de cuidados inten- sivos. Como conclusión, se destaca la importancia de mantener la vigilancia teniendo en cuenta un pensamiento clínico sobre los síntomas iniciales o de alerta de esta entidad, lo que permitirá realizar un diagnóstico precoz e iniciar un tratamiento oportuno y adecuado, logrando así reducir la morbimortalidad asociada.

Palabras clave: Fármacos antipsicóticos, complicaciones asociadas, síndrome, morbimortalidad.

Abstract:

The Neuroleptic Malignant Syndrome (NMS) is a peculiar and dangerous complication of treatment with antipsychotic drugs, which is characterized by fever, severe muscle stiffness and autonomic and mental status changes. We conducted a review of the epidemiological aspects, physiopatholog- ical, diagnosis and therapeutic approaches following a descriptive qualitative research with triangu- lation of information, results of the analysis of the clinical history, monitoring and evolution of case in intensive therapy and supported in the review of the scientific literature about this pathology, the clinical case of a patient who presented the NMS, after medication with antipsychotics, haloperidol type, associated with the administration of metoclopramide and presented  complications like cardi- ac arrhythmias, disorders of the internal environment and deep venous thrombosis of the left lower limb, which needed admission to the intensive care unit. As conclusion we highlight the importance of maintaining surveillance taking into account clinical thinking about early symptoms or warning of this entity, which will allow early diagnosis and initiate treatment timely and appropriate, and thus reducing the associated mortality and morbidity.

Key words: Drugs antipsychotic, associated complications, syndrome, morbidity and mortality.
Comportamiento del endotelio corneal con la técnica de Mini-Nuc, una experiencia con 50 pacientes
Authors: Martínez Carballo Martha
Published: December 2021

La cirugía de catarata es causa frecuente de edema corneal; este puede expresarse clínicamente en el postoperatorio inmediato o hacerlo muy tardíamente como consecuencia de la pérdida progresiva de células endoteliales que origina por sí mismo este procedimiento. Por este motivo, se realizó un estudio descriptivo, prospectivo, de corte longitudinal, con el objetivo de determinar las alteraciones del endotelio corneal en pacientes operados de catarata mediante la Técnica de Mini-Nuc, en el Hospital Calixto García. La investigación incluyó 50 pacientes que cumplieron con los criterios de inclusión y se realizó en el período comprendido entre septiembre de 2009 y septiembre de 2010. Algunos de los resultados más sobresalientes fueron: se evidenció modificación significativa de la densidad celular, el coeficiente de variabilidad y el índice de hexagonalidad luego de la realización del proceder quirúrgico, no sucediendo lo mismo con la paquimetría óptica. El polimegatismo y pleomorfismo aumentaron en el postoperatorio, al igual que la presencia de espacios acelulares. A pesar de comprobar la presencia en el postquirúrgico de alteraciones estructurales en el endotelio corneal, estas no comprometieron de manera irreversible su funcionamiento

Palabras clave: Endotelio corneal, postquirúrgicos, densidad celular, hexagonalidad, coeficiente de variabilidad, oftalmología.

 Abstract

Cataract surgery is a common cause of corneal edema; this can express itself clinically in the immediate postoperative period or late as a result of the progressive loss of endothelial cells that originates by itself this proceeding. In order to determine changes in the corneal endothelium in 50 patients with diagnosis of cataract operated by Mini Nuc technique, a descriptive and prospective study was conducted at the Hospital General Calixto García University, which met the criteria of inclusion, from September 2009 to September 2010. The outstanding results, showed the significant change cell density, coefficient of variability and the hexagonal index, while with the optical pachymetry was not the same. The polimegatism and pleomorphism and acellular spaces increased in the postoperative period. Despite presence of structural alterations in corneal endothelium during post-operatory period, they did not affect irreversibly the endothelium working.

Key words: Corneal endothelium, post-surgery, cell density, coefficient of variability and rate of hexagonal forms.
Pie de riesgo y su estratificación en diabéticos
Authors: Hidalgo Martínez Bárbara , Cabezas Jama Jennifer Alexandra , Velásquez Ochoa Edgar Stefano , Acosta Pérez Rasiel
Published: December 2021

El pie diabético es una complicación de la diabetes mellitus (DM) que puede controlarse con el manejo del pie de riesgo (PR). Con el objetivo de determinar la prevalencia de los factores predis- ponentes de esta patología y su estratificación en el paciente diabético, se realizó un estudio des- criptivo transversal, con 824 pacientes que asistieron a la consulta externa de endocrinología del Hospital Humberto Pozo, de febrero a julio de 2016. Para la estratificación, se utilizó el Sistema de Clasificación de Riesgos del Consenso Internacional del pie diabético. Se encontró que el 58,3% de los pacientes, presentó PR, el 30,7% en Grado 1 y 22,4% en Grado 2. Los factores predispo- nentes más frecuentes son la neuropatía (36,7%), la enfermedad vascular periférica (32,1%) y las deformidades ortopédicas (15,7%). Se identificó una elevada prevalencia de PR que permite con un correcto manejo de los factores predisponentes, prevenir lesiones y amputaciones.

Palabras clave: Pie de riesgo, pie diabético, amputación, prevención de pie diabético.

Abstract

Diabetic foot is a complication of diabetes mellitus that can be controlled with the management of the risk foot. In order to determine the prevalence of the predisposing factors of the risk foot and its stratification in the diabetic patient, a cross-sectional descriptive study was conducted with 824 dia- betic patients attending the outpatient clinic of endocrinology Humberto Pozo Hospital in the period from February to July 2016. For the stratification, the International Classification of Risks of the Dia- betic Foot Consensus was used. The most frequent predisposing factors were neuropathy (36.7%), peripheral vascular disease (32.1%) and orthopedic deformities (15.7%). A high prevalence of risk foot was identified that allows, with a correct management of the predisposing factors, to prevent injuries and amputations.

Key words: risk foot, diabetic foot, amputation, prevention of diabetic foot.
SCIENTIFIC AND INNOVATIVE CAPACITY FOR ESSENTIAL-OIL-BEARING AND MEDICINAL PLANTS PRODUCTION AND PROCESSING IN THE EURASIAN ECONOMIC UNION
Authors:   Research Institute of Agriculture of Crimea
Published: December 2021

This book presents the generalized analysis of the development of scientific and innovative potential in the member states of the Eurasian Economic Union (EAEU) in the context of essential-oil-bearing and medicinal plants production, processing and use. The authors suggest some approaches and directions for the revitalization and innovative development of the essential-oil-bearing and medicinal plants production sector that was once very successful by combining efforts within the EAEU. The book can be beneficial for scientists, students, production personnel, managers dealing with innovative development of the agricultural sector and sustainable development of territories.
Diagnosis of the Pancreatic Functional Insufficiency
Authors:   A.S. Loginov Moscow Clinical Scientific Center, Malykh M.V. , Dubtsova E.A. , Vinokurova L.V. , Kiryukova M.A. , Bordin D.S. ,   Tver State Medical University,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Published: December 2021

Exo- and/or endocrine pancreatic insufficiency are the complications and diagnostic criteria of chronic pancreatitis. Recently expanded surgical activity in pancreatic diseases prolongs overall survival in such patients. However, patients’ quality of life decreases due to exo- and endocrine pancreatic insufficiency. Timely diagnosis and adequate treatment of the conditions are based on the lab assessment of pancreatic function. The paper presents diagnostic methods, their sensitivity, specificity, and diagnostic role.
Antidepressants in the Practice of a Gastroenterologist
Authors:   A.S. Loginov Moscow Clinical Scientific Center, Firsova L.D.
Published: December 2021

Antidepressants are widely used in modern gastroenterology. The article discusses the indications for the prescribing antidepressants to the patients with disorders of the digestive system, examines the features of antidepressant therapy in the gastroenterological patients with comorbid cardiovascular pathology. The main groups of antidepressants (selective serotonin reuptake inhibitors and tricyclic antidepressants) are compared in terms of therapeutic effects and potential side effects
ЕКОЛОГІЧНИЙ ВИМІР ЗМІН У ЗЕМЕЛЬНИХ ВІДНОСИНАХ ТА ФОРМАХ ГОСПОДАРЮВАННЯ В УКРАЇНСЬКОМУ СЕЛІ (1990 – 2000-і роки)
Authors: Подрєз Ю. В. , Оліцький В. О.
Published: December 2021

Стаття присвячена вирішенню не дослідженому у наукових працях питанню екологічного виміру земельних відносин та господарювання в аграрному секторі України у 1990–2000-і роки. Автором проаналізовано спробу держави розробити та запровадити концепцію розвитку ринкових земельних відносин та спроби наукового середовища і окремих агровиробників втілити передові досягнення галузі. Визначено умови функціонування аграрної галузі в Україні та їх вплив на екологічний вимір діяльності. Наголошується на відсутності базового документа, який би спрямовував нормативну базу даного питання, що призвело до розпорошеності та безсистемності, а відповідно неефективності вітчизняної нормативно-правової бази. Відзначається, що через відсутність відповідного досвіду, наукового обґрунтування та відповідної нормативно-правової бази, в Україні ні орендарі, ні орендодавці не піклувалися про відтворення земельних ресурсів, екологічність агровиробництва.
ДЕПОРТАЦІЯ БОЙКІВ НА ДОНБАС 1951 р.: ПРОБЛЕМИ ПЕРЕСЕЛЕННЯ ОЧИМА СВІДКІВ
Authors: Стешенко Н. Л. , Бородай А. В. , Чоста К. С.
Published: December 2021

У статті досліджуються культурні, соціальні, кліматичні та інші проблеми переселення бойків на Донбас у 1951 р., спираючись на усні свідчення очевидців тих подій. Матеріали було зібрано під час краєзнавчої експедиції. Проаналізовано стан, тенденції і динаміку трансформації ідентичності депортованих бойків, нині жителів сіл Донецької області. Визначено масштаб та причини булінгу бойків з боку місцевого населення. Усні свідчення очевидців щодо культурних, соціальних, кліматичних та інших проблем переселення бойків на Донбас у 1951 р. є значущим та нетривким джерелом інформації стосовно деталей депортації. Шляхом інтерв’ю були отримані цінні факти щодо переселення жителів сіл Задвір’я та Гошів Нижньо-Устрицького району Дрогобицької області до сіл Яковлівка та Староварварівка Олександрівського району Донецької області. Було вивчено основні передумови та причини депортації, надана оцінка ролі влади в цьому процесі. Чітко окреслено умови депортації та порушення прав людини під час переселення. З’ясовано місце культурної спадщини бойків Донбасу в формуванні національної ідентичності, сучасних міжетнічних, міжконфесійних відносин. Також виявлено, що бойки після переселення зазнали чималої трансформації, пов’язаної із зовнішнім середовищем та оточенням
Scanning probe microscopy of biological objects and data processing
Authors:   Lomonosov Moscow State University, Yaminsky I.V. , Akhmetova A.I. , Senotrusova S.A.
Published: December 2021

The article tells about scanning probe microscopy, which has recently become a powerful tool for characterizing the structures and properties of living biological systems in aquatic conditions with unprecedented spatial resolution.
Intellectual support systems for management decisions to counter biological and chemical threats in healthcare
Authors:   Maikop State Technological University, Agirov A.H. , Alekhnovich A.V. ,   Central Military Clinical Hospital named after V.I. A.A. Vishnevsky, Belashev B.P. , Gukasov V.M. ,   Republican Research Scientific and Consulting Center for Expertise of the Ministry of Science and Higher Education of Russia, Zakharov V.A. ,   NIISSU JSC, Konyshev I.S. ,   State Research Institute of VM of the Ministry of Defense of the Russian Federation, Orlov D.A. ,   Research Institute of Communication and Control Systems, Stolyar V.P. ,   Military Medical Academy named after V.I. CM. Kirov, Tarasov B.V. ,   ZAO NPTs «Modul»
Published: December 2021

The main scientific and practical results of the implementation of the created system of intellectual support for managerial decisions (SIP-RA) to counteract biological and chemical threats in health care (on the example of the Republic of Adygea) are presented.
LA EDUCACION EN EL PERÚ DE LA POSINDEPENDENCIA A TRAVES DE SUS TEXTOS
Authors: Contreras Carlos
Published: December 2021

Partiendo de un retrato de la situación de la educación en los años iniciales de la historia del Perú independiente, el artículo rastrea la política desplegada por el Estado en materia de organización de las escuelas y establecimiento de contenidos de lo que se enseñaba a los alumnos en los niveles elemental o básico y el intermedio o secundario. Para ello nos centramos en un análisis de los textos más empleados en las escuelas del Perú entre los años 1821-1850. Llegamos a la conclusión de que el Estado puso poco empeño en regular los materiales empleados en las escuelas, de modo que los textos empleados en ellas lo fueron, principalmente, por iniciativa de educadores que dirigían escuelas privadas en Lima u otras ciudades importantes. El contenido de dichos textos recogió solo débilmente los ideales de la independencia y de la república como forma de gobierno y convivencia social, y fundamentalmente heredó los planteamientos que venían usándose en la época virreinal.
Socially Inclusive Versus Uneven Development: Developed and Peripheral Economies in a Global Context
Authors: Luis-Pineda Octavio
Published: December 2021

After the Cold War and the fall of Berlin Wall in 1989, a new world order led by the USA emerges as the axis of a new unipolar order that brings with it economic liberalization and the globalization process, implanted an economic strategy nurtured in the spirit of liberalism. Adam Smith's 18th century economic economy from "Laissez Faire Laissez Passer" upholds the economic self-regulation of nations without state intervention. Currently becoming the neoliberal strategy that has dominated the world scene for more than forty years.
Although its planetary implementation has generated benefits due to the associated boom in international trade in the global market, it has also led to adverse effects in different ways and intensities, both among developed and peripheral economies. Such as a greater economic distancing between rich and poor at the planetary level, regional imbalances and greater polarization of wealth in peripheral economies, and multiple externalities and exacerbation of their structural problems.