bluuebunny/crossref_metadata_2025 huggingface dataset:
Reversine: A Synthetic Purine with a Dual Activity as a Cell Dedifferentiating Agent and a Selective Anticancer Drug
Authors: Piccoli Marco , Ghiroldi Andrea , Monasky Michelle M. , Cirillo Federica , Ciconte Giuseppe , Pappone Carlo , Anastasia Luigi
Published: January 2019

The development of new therapeutic applications for adult and embryonic stem cells has
dominated regenerative medicine and tissue engineering for several decades. However, since 2006,
induced Pluripotent Stem Cells (iPSCs) have taken center stage in the field, as they promised to overcome
several limitations of the other stem cell types. Nonetheless, other promising approaches for adult
cell reprogramming have been attempted over the years, even before the generation of iPSCs. In particular,
two years before the discovery of iPSCs, the possibility of synthesizing libraries of large organic
compounds, as well as the development of high-throughput screenings to quickly test their biological
activity, enabled the identification of a 2,6-disubstituted purine, named reversine, which was
shown to be able to reprogram adult cells to a progenitor-like state. Since its discovery, the effect of
reversine has been confirmed on different cell types, and several studies on its mechanism of action
have revealed its central role in inhibitory activity on several kinases implicated in cell cycle regulation
and cytokinesis. These key features, together with its chemical nature, suggested a possible use of the
molecule as an anti-cancer drug. Remarkably, reversine exhibited potent cytotoxic activity against
several tumor cell lines in vitro and a significant effect in decreasing tumor progression and
metastatization in vivo. Thus, 15 years since its discovery, this review aims at critically summarizing
the current knowledge to clarify the dual role of reversine as a dedifferentiating agent and anti-cancer
drug.
An Invasive Hemolymphangioma of the Pancreas in a Young Woman
Authors: Zhang Zhijun , Ke Qinghong , Xia Weiliang , Zhang Xiuming , Shen Yan , Zheng Shusen
Published: January 2019

Background:

Hemolymphangioma is a rare benign tumor. To the best of our knowledge,
there were only 10 reports of this tumor of the pancreas until March 2018.

Case Report:

Here, we reported a large invasive hemolymphangioma of the pancreas in a young
woman with a complaint of abdominal distension and an epigastric mass about 3 weeks. She was
found to have a huge multilocular cystic tumor at the neck and body of pancreas on computed
tomography. She was eventually diagnosed with hemolymphangioma of the pancreas after operation.
After 2 years of follow-up, there was no signs of recurrence.

Conclusion:

From our case and literature, we can conclude that hemolymphangioma of the pancreas
is uncommon benign tumor, and it is hard to make an accurate diagnosis preoperatively. Radical
surgical resection should be performed whenever possible. The prognosis of this disease seems good.
Antimicrobial Activity of Myrtus communis L., Cinnamomum verum and Eugenia caryophyllata Alcoholic Mixtures
Authors: Zam Wissam , Ali Ali , Ibrahim Walaa
Published: January 2019

Background and Objective:

With the significant increase in the prevalence of infectious
diseases and the development of drug resistance by human pathogenic bacteria, there is a continuous
need to discover new antimicrobial compounds from plants.

Methods:

Four extracts of wild Myrtus communis L. berries (myrtle berries) were prepared with the
addition of Cinnamomum verum and Eugenia caryophyllata. The extracts were screened in vitro for
their antimicrobial activities using agar-well diffusion method against Escherichia coli, Staphylococcus
aureus, Enterobacter cloacae, Listeria monocytogenes, Pseudomonas aeruginosa and Proteus
mirabilis cultures.

Results:

The inhibition zones ranged from 12 to 22 mm. The MICs values of extracts lies between
the ranges of 30 to 100 mg/ml. Of the extracts studied, the most active ones were those obtained from
the myrtle berries:cloves, myrtle berries:cinnamon:cloves with the highest inhibition zones 22 mm
and 17mm against S. aureus and L. monocytogenes at 50 mg/ml and 80 mg/ml, respectively. None
of the extracts was active against E. coli and P. mirabilis.

Conclusion:

The present investigations have exposed that the myrtle berries:cloves, myrtle berries:
cinnamon:cloves extracts could be used in traditional medicine as natural antimicrobial agents in
treatment the bacterial infections.
Isolation and HPLC Determination of the Chemical Components of Gentianella acuta (Michx.) Hulten
Authors: Wei Ying , Liu Yongqiao , Hele Yifan , Sun Weiwei , Wang Yang , Xu Tunhai , Liu Tonghua
Published: January 2019

Background:

Gentianella acuta (Michx.) Hulten is an important type of medicinal plant
found in several Chinese provinces. It has been widely used in folk medicine to treat various illnesses.
However, there is not enough detailed information about the chemical constituents of this plant or
methods for their content determination.

Objective:

The focus of this work is the isolation and characterization of the major chemical constituents
of Gentianella acuta, and developing an analytical method for their determination.

Methods:

The components of Gentianella acuta were isolated using (1) ethanol extraction and adsorption
on macroporous resin. (2) and ethyl acetate extraction and high speed countercurrent chromatography.
A HPLC-DAD method was developed using a C18 column and water-acetonitrile as the mobile
phase. Based on compound polarities, both isocratic and gradient elution methods were developed.

Results:

A total of 29 compounds were isolated from this plant, of which 17 compounds were isolated
from this genus for the first time. The main components in this plant were found to be xanthones. The
HPLC-DAD method was developed and validated for their determination, and found to show good
sensitivity and reliability.

Conclusion:

The results of this work add to the limited body of work available on this important medicinal
plant. The findings will be useful for further investigation and development of Gentianella
acuta for its valuable medicinal properties.
Development & Pharmaceutical Characterization of Isoniazid Loaded Solid Lipid Nanoparticle Drug Delivery Approach
Authors: Kushwaha Swatantra Kumar Singh , Rai Awani Kumar , Parveen Heena
Published: January 2019

Background:

Tuberculosis is a major public health problem in the world.
Isoniazid is a first line antitubercular drug active against Mycobacterium species which
inhibits mycolic acid synthesis.

Objective:

The aim of the present investigation was the preparation of solid lipid nanoparticle
containing Isoniazid to increase bioavailability, sustained release and decrease toxicity
by increasing permeability.

Methods:

Isoniazid was incorporated into SLN for sustained drug delivery, increasing
permeability and bioavailability. SLNs were prepared by emulsification followed by the
solvent evaporation technique by optimizing lipid, polymer and surfactant ratio under
controlled optimized process variables i.e. temperature and stirring speed. SLNs were
characterized for particle size analysis, comparative study design in different physiological
pH for in-vitro drug release and drug release kinetics.

Results:

The best in-vitro release for F7 was found to be 80.2% in pH-7.4 and 82.2% in
pH-4.5. The particle size of the F7 formulation was found to be in the range of 200-
600nm . Among all 3 optimized formulations, i.e. F3, F7 and F8 in both the pH, F3
followed non-fickian diffusion mechanism in pH-4.5 whereas all the formulations in both
pH followed super-case II diffusion mechanism. The stability studies were carried out
as per ICH guidelines which signify that the SLNs were found stable in the refrigerated
condition.

Conclusion:

The results clearly demonstrated that SLNs drug delivery system is a promising
approach for antitubercular drug delivery as it proved to sustained release, increase
permeability, enhanced bioavailability and thus decreased dosing frequency. Kinetic
modelling of the formulation with zero, first order, Higuchi and Korsmeyer- peppas is
explained in this article.
Tobacco Smoking: Risk to Develop Addiction, Chronic Obstructive Pulmonary Disease, and Lung Cancer
Authors: Santoro Alessia , Tomino Carlo , Prinzi Giulia , Lamonaca Palma , Cardaci Vittorio , Fini Massimo , Russo Patrizia
Published: January 2019

Background: The morbidity and mortality associated with tobacco smoking is well established.
Nicotine is the addictive component of tobacco. Nicotine, through the non-neuronal α7nicotinic
receptor, induces cell proliferation, neo-angiogenesis, epithelial to mesenchymal transition, and inhibits
drug-induced apoptosis.

Objective:

To understand the genetic, molecular and cellular biology of addiction, chronic obstructive
pulmonary disease and lung cancer.

Methods:

The search for papers to be included in the review was performed during the months of July-
September 2018 in the following databases: PubMed (http://www.ncbi.nlm.nih.gov), Scopus
(http://www.scopus.com), EMBASE (http://www.elsevier.com/online-tools/embase), and ISI Web of
Knowledge (http://apps.webofknowledge.com/). The following searching terms: “nicotine”, “nicotinic
receptor”, and “addiction” or “COPD” or “lung cancer” were used.

Patents were retrieved in clinicaltrials.gov (https://clinicaltrials.gov/). All papers written in English
were evaluated. The reference list of retrieved articles was also reviewed to identify other eligible
studies that were not indexed by the above-mentioned databases.

New experimental data on the ability of nicotine to promote transformation of human bronchial epithelial
cells, exposed for one hour to Benzo[a]pyrene-7,8-diol-9-10-epoxide, are reported.

Results:

Nicotinic receptors variants and nicotinic receptors upregulation are involved in addiction,
chronic obstructive pulmonary disease and/or lung cancer. Nicotine through α7nicotinic receptor upregulation
induces complete bronchial epithelial cells transformation.

Conclusion:

Genetic studies highlight the involvement of nicotinic receptors variants in addiction,
chronic obstructive pulmonary disease and/or lung cancer. A future important step will be to translate
these genetic findings to clinical practice. Interventions able to help smoking cessation in nicotine
dependence subjects, under patent, are reported.
Eyelid Dermatitis and Contact Sensitization to Nickel: Results from an Italian Multi-Centric Observational Study
Authors: Borghi Alessandro , Corazza Monica , Maietti Elisa , Patruno Cataldo , Napolitano Maddalena , Schena Donatella , Musumeci Maria Letizia , Micali Giuseppe , Magrone Thea , Romita Paolo , Foti Caterina
Published: January 2019

Background:

Due to the sensitizing constituents of eye cosmetics, allergic contact dermatitis
is considered a frequent cause of eyelid dermatitis. An association between eyelid dermatitis and nickel
contained in make-ups remains controversial.

Objective:

The study aimed to assess the association between nickel allergy, the use of pigmented makeup
products and self-reported eyelid dermatitis.

Method:

This multi-centric, cross-sectional study enrolled 165 women sensitized to nickel (patients)
and 103 women without intolerance to metals (controls). We recorded: demographics, atopy, use of
pigmented eye cosmetics (mascara, eyeshadow, eyeliner, eyebrow pencil), and previous eyelid dermatitis.
Among the patients, any co-sensitization to cosmetics or metals was recorded.

Results:

87.3% of the patients and 91.3% of the controls reported their use of eye make-up; 44.9% and
52.4%, respectively, reported previous episodes of eyelid dermatitis, without significant differences.
The occurrence of eyelid dermatitis was significantly associated with the use of eye make-up products,
both in general and considering each product separately. Age, atopy, or co-sensitization to other metals
or cosmetics did not affect the occurrence of eyelid dermatitis.

Conclusion:

Nickel allergy should not be considered the main risk factor for eyelid dermatitis. The use
of pigmented eye make-up may be a triggering factor for eyelid dermatitis, probably due to an irritant
action.
Therapeutic Potential of Morin in Ovalbumin-induced Allergic Asthma Via Modulation of SUMF2/IL-13 and BLT2/NF-kB Signaling Pathway
Authors: Kandhare Amit D. , Liu Zihao , Mukherjee Anwesha A. , Bodhankar Subhash L.
Published: January 2019

Background:

Allergic asthma is a chronic immune-inflammatory disorder, characterized by airway inflammation and airway hyperresponsiveness (AHR). Morin is a natural flavonoid reported to exhibit inhibitory action against IgE-mediated allergic response.

Aim:

To determine the efficacy of murine model of ovalbumin (OVA)-induced AHR inhibition by morin and decipher the molecular mechanism involved.

Materials and Methods:

Sprague-Dawley rats were sensitized and challenged with OVA to induce AHR. Rats received treatment with morin (10, 30 and 100 mg/kg, p.o.) for the next 28 days.

Results:

Morin (30 and 100 mg/kg) significantly and dose-dependently attenuated (p < 0.01 and p < 0.001) OVA-induced alterations in pulse oxy and lung function test, increased bronchoalveolar lavage fluid cell counts, elevated total protein and albumin levels in serum, BALF, and lungs, increased serum total and OVA-specific IgE levels and, elevated oxidative stress levels in the lung. RT-PCR analysis revealed that morin treatment (30 and 100 mg/kg) significantly (p < 0.001) up-regulated SUMF2 mRNA expression in lungs whereas mRNA expressions of BLT2, NF-κB, and Th2-cytokine (TNF-α, IL-1β, IL-4, IL-6, and IL-13) were down-regulated significantly and dose-dependently (p < 0.01 and p < 0.001). Also, histologic and ultrastructural studies showed that morin significantly inhibited (p < 0.001) OVAinduced perivascular and peribranchial inflammatory infiltration and interstitial fibrosis.

Conclusion:

Morin exhibited inhibitory effect against OVA-induced allergic asthma by activation of SUMF2 which impeded IL-13 expression and in turn attenuated Th2-cytokines, BLT2, NF-κB, and IgE levels to ameliorate AHR. Thus, our findings suggested that morin could be considered as a potential alternative therapeutic agent for the management of allergic asthma.
The Alkaloids and Bioactivities of Ethanol Extract from a Traditional Remedy of Vietnam
Authors: Sa Nguyen H. , Thuy Trinh T. , Quan Tran D. , Thien Dao D. , Tam Nguyen T. , Hoan Le C. , Nhung Le T.H. , Ni Huynh T.N. , Adorisio Sabrina , Delfino Domenico V.
Published: January 2019

Background and Objective:

In Vietnam, “Dai trang hoan ba Giang” (BG), which belongs
to herbalist “Ba Giang”, has been one of the famous herbal remedies for ulcerative colitis and diarrhea
for over 100 years. However, up to the present, the main BG’s chemical constituents have not
been investigated. Therefore, this study aims to investigate the phytochemistry and antiproliferative
activity of isolated compounds from BG on Acute Myeloid Leukemia (OCI-AML) cells as well as
evaluating its safety by the acute and subchronic toxicological tests.

Methods:

Compounds from herbmaterial were isolated by using column chromatography. Their
structures were determined by combining spectral analysis and comparison with reported data. The
concentrations of components were were determined by HPLC/DAD analysis. Anti-proliferative activity
in OCI-AML cell line of isolated compounds was carried out by flow cytometry analysis. The
acute and subchronic oral toxicity in micewere appraised by observingdaily for clinical manifestations
of toxicity while the experiment lasted.

Results:

In this study, driedpowders of materials were extracted by 70% EtOH to afford an extract
(DTBG). Two compounds, including palmatine (1) and berberine (2) were isolated from DTBG.
The DTBG inhibited the growth of OCI-AML by a significant increase of caspase-8-independent
apoptosis as measured by propidium iodide flow cytometry analysis and caspase-3 activation. In the
acute study, DTBG is well tolerated, non-toxic and non-lethal to mice under the present experimental
conditions. In thesubchronic study in mice, DTBG did not impact on weight gain, blood, liver
and kidney function.

Conclusion:

Overall, the main chemical constituents of DTBG and its effect on proliferation of
acute myeloid leukemia cells were reported for the first time. Moreover, the results suggest that,
DTBG did not express any significant toxic effect in mice. Hence, the extract can be utilized for
pharmaceutical formulations.
Pseudarthrosis of the Carpal Scaphoid Treated with Non-Vascularized Corticocancellous Bone Graft
Authors: Mourafiq Omar , Kamenan Valery , Benyias Youssef , Boukhriss Jalal , Chefry Bouchaib , Bencheba Driss , Bouabid Ahmed Salim , Boussouga Moustapha
Published: December 2018

Objectives: To carry out an epidemiological study and to assess the evolutionary profile of patients with scaphoid non-union treated by anterior non-vascularized corticocancellous bone graft.

Introduction: The non-union is a serious complication of carpal scaphoid fractures. Untreated, it leads to instability and osteoarthritis of the carp. The most used technique is that of Matti-Russe employing a corticocancellous graft.

Materials and methods: We report in this retrospective study the experience of the department of Orthopaedic Surgery & Traumatology II, Mohamed V Military Hospital, Rabat, in the treatment of non-unions of the carpal scaphoid by anterior non-vascularized corticocancellous graft in nine cases collected between January 2012 and March 2016. We identified six cases of stage IIA and three cases of stage IIB. All our patients were operated by the Matti-Russian technique followed by an immobilization by plaster cast cuff on three months.

Results: All our patients achieved a union within an average of three months. The Mayo Wrist score was excellent in 66.6% of cases. Our results were very satisfying in 90% of cases, satisfying in 10%.

Conclusion: The treatment of non-unions of the carpal scaphoid without necrosis or osteoarthritis, using anterior non-vascularized bone graft remains the most widely used technique. The presence of initial instability is a factor of poor prognosis, its correction reduces the risk of arthritis.
Clinical Peculiarities of the Mixed-Invasion of Giardiasis and Ascariasis
Authors: Protsyk Andrii
Published: December 2018

Intestinal parasitic diseases are widespread in the territory of almost the entire globe. Among them the most common are giardiasis and ascaridosis. In recent years, more and more cases of combined invasion by these organisms have been registered.

The objective of the research was to study the clinical peculiarities of the course of giardiasis and ascariasis in patients with combined invasion.

Materials in the methods. There were 42 patients under observation, who were divided into 3 groups. The first group (n=14) included patients with giardiasis, the second one (n=14) – patients with ascariasis, the third group (n=14) included patients with mixed infection of giardiasis and ascariasis.

Results. The main clinical syndromes in patients with giardiasis, ascariasis and patients with mixed invasion by both pathogens have been analyzed. In all groups of patients, the manifestations of dyspeptic syndrome were most frequent. Signs of an allergic syndrome were observed as a polymorphic rash on the skin. Data on astheno-neurotic and intoxication syndromes took place somewhat less frequently.

Conclusions. Clinical manifestations in patients with mycobacterial invasions of giardiasis and ascariasis were reported more frequently than in patients with monoinvasion, and more pronounced polymorphism was observed.
Diagnostics and Minimally Invasive Surgery for Achalasia Cardia
Authors: Ratchik Vadim , Babii Oleksandr , Prolom Natalia , Shevchenko Boris
Published: December 2018

The objective of the research was to assess the effectiveness of balloon pneumatic dilation and laparoscopic Heller myotomy in treatment of patients with achalasia cardia.

Materials and methods. Twenty-one patients with achalasia cardia were examined and treated using pneumatic balloon dilation and laparoscopic Heller myotomy in the Department of Surgery from January 2016 to April 2018. There were 8 (38.1%) men and 13 (61.9%) women at the age of 28 to 75 years (the average age was (51.47 ± 3.63) years) and disease duration of 1 month to 8 years (the average disease duration was (3.05 ± 0.49) years).

            Results and discussion. With the help of radiological methods of examination, all the patients were divided into 4 groups according to the esophageal diameter: Group I included 5 (23.8%) patients with the esophagus up to 4-5 cm in diameter; Group II comprised 6 (28.6%) patients with the esophagus up to 4-6 cm in diameter; Group III included 5 (23.8%) patients with the esophagus up to 6-8 cm in diameter; Group IV consisted of 5 (23.8%) patients with the esophagus of more than 8 cm in diameter and an S-shaped configuration. A significant decrease in the diameter of the esophagus according to fluoroscopy (p<0.05) alongside with a decrease in the lower esophageal sphincter pressure according to manometry are indicative in assessing the effectiveness of achalasia cardia treatment after minimally invasive surgery. There were no complications when performing pneumatic balloon dilation and laparoscopic Heller myotomy.

            Conclusions. In 7 (33.3%) patients, recurrences of achalasia cardia after balloon pneumatic dilation occurred within 2 - 10 months: in 4.7% of patients in Group I and 9.5% of patients in Group II, Group III, and Group IV. In recurrent achalasia cardia, repeated dilation was ineffective. There was performed laparoscopic Heller myotomy with Dor fundoplication, which was effective in 80.0% of cases.
Histomorphological Effects of Cottonseed Oil on Testes in Adult Male Wistar Rats
Authors: Chris-Ozoko Lilian Ebele , Okpe Onome , Iju Wilson Josiah , Oyem John Chukwuma
Published: December 2018

Cottonseed oil is an extract from the seeds of cotton plant, that is rich in protein, carbohydrate and fiber.

         The objective of the research was to study the effect of cottonseed oil on the histology of the testis.

         Materials and methods. Twelve adult male Wistar rats weighing 200 – 250g, were randomly sorted into four groups (I - IV), each containing three animals. Cottonseed oil was administered orally to the experimental animals by means of an orogastric tube. The rats in Group I (the control group) received standard rat pellet and oral normal saline ad libitum only. The animals in Groups II, III, and IV received 0.2 ml, 0.6 ml and 1.0 ml of cotton seed oil per body weight respectively. On the 21st day, the animals were sacrificed by cervical dislocation. The testes were excised and, then, fixed with appropriate fixatives for routine tissue processing.

         Results. The results revealed an increase in the luminal diameter of seminiferous tubules, a decrease in the Leydig cell population, the disorientation of spermatogenic series and their detachment from the germinal epithelium.

         Conclusions. The present study demonstrated that oral administration of cottonseed oil to male rats displayed a deleterious effect on their testis by disrupting spermatogenesis and the histological architecture of the testis.
Interest of Surgical Treatment of Per-Trochanteric Fractures by Gamma Nail: About 100 Cases
Authors: Mourafiq Omar , Benyias Youssef , Benomar Hicham , Kamenan Valery , Boukhriss Jalal , Chefry Bouchaib , Bouabid Ahmed Salim , Bencheba Driss , Boussouga Moustapha
Published: December 2018

Gamma nail closed osteosynthesis has surpassed several methods previously used in the treatment of fractures in the trochanteric region.

         The objective of the research was to carry out an epidemiological study and to assess the evolutionary profile of patients with per-trochanteric fracture treated with gamma nail.

         Materials and methods. In this retrospective study, we report the experience of the Traumatology-Orthopedics Service II of the Military Teaching Hospital Mohamed V-Rabat, in the treatment of per-trochanteric fractures by gamma nail in 100 cases, collected between January 2011 and March 2016.

         Results. The average age of our patients was 68 years, with a male predominance of 67%. The most reported etiology (92% of cases) was simple drop. Stable fractures were the most common (81%), with a predominance of simple per-trochanteric fractures. The average response time was 24 hours, the average duration of the surgical procedure was 45 minutes. The rate of infectious complications was 1%; the rate of mechanical complications was 1%. The functional results were excellent and good in 95% of cases. The average consolidation time was 8 weeks.

         Conclusions. Trochanteric fracture is a delayed emergency which is seen primarily in the elderly. The gamma nail represents one of the latest improvements in implants for the treatment of these fractures. We report a series of 100 cases of trochanteric fractures treated surgically by gamma nail. The functional results were very encouraging compared to those reported in the literature.
Use of Modern Methods of Diagnostic of Occlusal Disorders in Patients with Carious Disease
Authors: Oleksyn Khrystyna , Rozhko Mykola
Published: December 2018

Occlusal disorders are one of the key problems in dentistry. They are observed at many dental diseases, resulted in the emergence of pathological processes in chewing system. Tooth decay is one of the factors that leads to disorders of occlusion. The purpose of our research is the study of occlusal disorders in patients with carious disease using modern methods of diagnostics, namely, technology of laser fluorescence and computer analysis of occlusion. 110 students of first 3 years of study at Ivano-Frankivsk National Medical University at the age of 17-20 with carious lesions of first molars were examined for the diagnostic of relationship between occlusal contacts. They were the citizens of the regions with low level of fluoride. 20 students with carious lesion of the dentin were selected to determine the nature of occlusal disorders. Analysis of occlusion was performed with the help of computerized system T-Scan Novus. Results of the study indicate that carious process has direct impact on the occurrence of occlusal disorders.
Psychological meaningfulness at work as a mediator of job characteristic and job attachment in public elementary schools in Yogyakarta
Authors: Akmadelita Welly Putri , Kusumaputri Erika Setyanti
Published: December 2018

This study aims to determine the relationship between job characteristics toward work engagement through the mediating psychological meaningfulness. Subjects in this study were a primary school teacher in Yogyakarta who totaled 132 (N=132) of teachers. Our data was collected using the work engagement scale (vigor, dedication, and absorption), job characteristics scale (skill variety, task identity, task significance, autonomy, and feedback), and psychological meaningfulness scale (meaningful work, others around the work environment, the work context, and spiritual life) — the methods of data analysis used path analysis techniques developed from regression analysis. Results of path analysis indicated that indirect effect was significant (p2 0.332 x 0.332 = 0.110) and the direct effect of 0511. Therefore, the total effect of the work engagement is direct and indirect effect that is 0.511 + 0.110 = 0.621 (62.1%). This means that hypotheses were accepted, there is a correlation between job characteristics toward work engagement through psychological meaningfulness as a mediator, where the suitability of job characteristics will improve work engagement through psychological meaningfulness as a mediator, where the suitability of job characteristics will improve work engagement through psychological meaningfulness that also higher on the teacher.
Happiness in early childhood
Authors: Izzaty Rita Eka
Published: December 2018

This research was conducted based on three considerations. Firstly, childhood is a critical developmental stage that forms the foundation for the psychological well-being and future learning development of children. Secondly, the prevalence of child and adolescent behavioral problems is increasing, assumed to be caused by unhappiness. Thirdly, studies related to happiness in early childhood in Indonesia are still lacking. Therefore, this study aims to explore the meaning, situation, and parties associated with happiness in children. Our study is exploratory using a qualitative approach. The respondents include 51 children aged 4 to 6 years. The research took place in the Special Region of Yogyakarta. We interviewed the respondents and later analyzed the data using content analysis. The latter consist of three coding steps: open coding, axial coding, and selective coding. The results show that, 1) the meaning of happiness refers to positive affects (55%), activities (28.9%), getting something (8.89%), positive physical conditions (4.44%), and affiliation (2.22%), 2) The situations that make children happy are activities (36.61%), learning (11.61%), entertainment (9.82%), and sports (2.62%), 3) The parties who make children happy are families (77.92%), extended families (3.90%), non-family (19.48%), God (1.30%) and toys (1.30%).
Developing an instrument for measuring the spiritual attitude of high school students
Authors: Hudha Safa'at Ariful , Mardapi Djemari
Published: December 2018

Attitudinal competence is one the most fundamental concepts in social psychology. It is related to personal identity, moral, and ethics that gains popularity and becomes important in educational development. This research aims to develop an instrument to measure the spiritual attitude of high school students. The study was a research and development study consisting of four stages: (a) determining conceptual definition, (b) determining operational definition, (c) drawing indicators, and (d) constructing instrument. The quantitative data analysis was used to test the construct validity through Confirmatory Factor Analysis and the coefficient of construct reliability was used to estimate the instrument reliability. The results of the study show that: (1) the instrument to measure Moslems’ spiritual attitude is an inventory model of summated rating scale containing 35 items; (2) the construct validity was proven by the value of the standardized loading factor and considered as significant. The instrument reliability regarded as the construct reliability coefficient is 0.890 and the average variance extracted is 0.542; (3) the construct of the instrument produces a fit statistical evidence indicated by the Goodness of Fit Index = 0.91 (≥0.90), and Root Mean Square Error of Approximation = 0.032 (≤0.08). The results indicate that the construct of the measurement is suitable with the data. In addition, this research has confirmed that the spiritual attitude of high school students is constructed by seven aspects, namely resignation (tawakal), sincerity (ikhlas), thankfulness (syukur), patience (shabr), fear (khauf), hopefulness (raja’), and righteousness (takwa).
PROVA BRASIL, IDEB E ESCOLAS RURAIS DO TERRITÓRIO DO PIEMONTE DA DIAMANTINABAHIA: REGULAÇÃO DO TRABALHO DOCENTE NA EDUCAÇÃO RURAL
Authors: Souza Elizeu Clementino de , Ramos Michael Daian Pacheco
Published: December 2018

O artigo analisa a configuração da regulação do trabalho docente em escolas rurais do Território do Piemonte da Diamantina-Bahia, por meio da aplicação de avaliações externas em larga escala. Investigamos a disposição dos estabelecimentos de ensino da zona rural, do território destacado, na Prova Brasil em 2015 e refletimos sobre seus respectivos Índices de Desenvolvimento da Educação Básica (Ideb). Para isso, realizamos uma pesquisa com caráter documental nas bases de dados do Instituto Nacional de Pesquisa Educacional Anísio Teixeira (Inep). Nossos principais resultados foram: a) há uma maior participação na Prova Brasil 2015, proporcionalmente, de escolas urbanas que de escolas rurais; b) apenas 38% das escolas rurais do território investigado participaram da Prova Brasil 2015, contudo a disposição da participação no interior dos municípios é diversa e heterogênea; c) um terço das escolas rurais que participaram do exame não obtiveram nota de Ideb; d) um terço das unidades educacionais rurais avaliadas alcançaram a meta e outro um terço não alcançou e; e) nos anos iniciais do ensino fundamental o território apresenta uma disposição positiva no alcance do Ideb entre os anos de 2005 e 2017, contudo, nos anos finais do ensino fundamental será necessário uma maior atenção de alguns municípios.
PROJETO ESCOLA EM TEMPO INTEGRAL NO MUNICIPIO DE JOÃO PESSOA-PB: contextos e prática
Authors: Ferreira Ruttany Souza Alves , Rodrigues Cibele Maria Lima , Oliveira Gilvaneide Ferreira de
Published: December 2018

O presente artigo objetiva analisar o contexto de implantação do Projeto “Escola de Tempo Integral” em uma escola de ensino fundamental na cidade de João Pessoa-PB, assim como compreender como esta política é efetivada na prática em uma escola de ensino fundamental (anos iniciais) da rede municipal. Para coleta de dados foram realizadas entrevistas semiestruturadas e observações. Como principais resultados encontrou-se que o modelo adotado em João Pessoa está centrado na ampliação do tempo, na perspectiva do aluno em tempo integral. O Projeto em tela possui visíveis influências do Programa Mais Educação. Na prática, a extensão da carga horária está atrelada à proteção social. Também se organiza a partir do discurso das avaliações padronizadas ao reforçar o estudo dos conteúdos curriculares de português e matemática, visando elevar as médias nas referidas disciplinas. Além disso, a Secretaria possui um sistema próprio de avaliação que segue a mesma lógica – o chamado Programa Escola Nota 10. Os sujeitos que desempenham funções docentes, em especial as professoras e tutoras, são cobrados para que as crianças atinjam o desempenho necessário a fim de ganhar a premiação do Programa Escola Nota 10. Desse modo, o trabalho da instituição gira em torno das normas de tal Programa.
A MODERNIZAÇÃO “EFICAZ” DA PROFISSÃO DE PROFESSOR CONFRONTADA ÀS NOVAS POLÍTICAS DE ACCOUNTABILITY
Authors: Normand Romuald
Published: December 2018

Atualmente, a reestruturação da profissão de professor tende a se inscrever em todos os lugares na Europa no que se refere ao estabelecimento de objetivos, medidas de performance ou de eficácia, mesmo se há construções diferentes de um país a outro. A eficiência e a eficácia do corpo docente devem permitir uma melhoria dos resultados dos exames e dos testes aos alunos. A Nova Gestão Pública se funda sobre os princípios da racionalidade econômica e financeira, visando a eficiência, a eficácia e se apoiando sobre organismos reguladores (ministérios e agências) que reforçam a exigência da prestação de contas (accountability). Este acoplamento entre gestão e avaliação serve para justificar o domínio da despesa pública em educação e, mais particularmente, a racionalização do custo da gestão de recursos humanos. O artigo examina, de maneira crítica, os efeitos desta gerência da performance sobre os professores da educação, mostrando como as políticas de prestação de contas se renovam por meio de seus conteúdos e instrumentos.
ESTADO DO CONHECIMENTO DE QUESTÕES DE GÊNERO NA EDUCAÇÃO INFANTIL
Authors: Cavalcanti Fernanda Carvalho , Gurgel Paulo Roberto Holanda
Published: December 2018

O objetivo deste artigo é analisar estudos realizados sobre questões de gênero na Educação Infantil no período de 2010 a 2015. Dissertações e teses sobre a temática foram selecionadas e, posteriormente, organizadas em quatro categorias: gênero e as representações e discursos de professoras e de professores da Educação Infantil; gênero e o professor da Educação Infantil; gênero e a educação de meninos e de meninas na Educação Infantil; gênero associado ao embelezamento na Educação Infantil. As fontes utilizadas foram relatórios de pesquisa disponíveis no banco de teses e dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes). Conforme critérios estabelecidos, 20 trabalhos foram selecionados: quatro teses e 16 dissertações. As análises indicam escassez de pesquisas sobre a temática além da necessidade de um olhar para a formação de professoras e de professores, assim como a formulaçãode políticas públicas para a superação das desigualdades e estereótiposde gênero em todas as relações que se estabelecem no âmbito da Educação Infantil.
CULTURA DE ALUNOS ADOLESCENTES DO ENSINO MÉDIO: dinâmicas e contextos
Authors: Sant’Ana Ruth Bernardes de
Published: December 2018

Este artigo empreende uma releitura de publicações consideradas relevantes no debate sobre a relação entre as culturas juvenis e as culturas escolares, com o objetivo de teorizar acerca das formas assumidas pela cultura dos alunos no interior dessa relação no Ensino Médio. A cultura dos alunos constitui um fio condutor importante para a compreensão da escola na vida da juventude numa sociedade em que a escolarização está no centro do processo de desigualdade de acesso a bens físicos e simbólicos. Assim, as questões que este trabalho procurou responder são as seguintes: O que é cultura dos alunos? Como ela se manifesta na escola de Ensino Médio em diferentes contextos sociais?
NO “FIO DA NAVALHA”: projetos de futuro de jovens em privação de liberdade
Authors: Almeida Jorddana Rocha de , Leão Geraldo
Published: December 2018

O artigo discute os projetos de futuro de jovens em conflito com lei baseando-se nos resultados de uma pesquisa com adolescentes que cumpriam medida de semiliberdade em um município do interior de Minas Gerais. Os dados foram coletados por meio da análise de documentos, observação participante e entrevistas semiestruturadas com 16 jovens com idades entre 13 e 18 anos. As experiências juvenis, em suas múltiplas dimensões, se constituíram em um contexto sociocultural de vulnerabilidade e de relações sociais marcadas por violações de direitos sociais e de processos de desumanização. As experiências da medida socioeducativa de semiliberdade foram vivenciadas como desafiadoras, demarcadas por conflitos com os adultos e os colegas, vistas pelos participantes como situações de provações constantes. A relação com o projeto de futuro se revelou como uma dimensão distante, prevalecendo uma adesão ao tempo presente.
A EQUILIBRAÇÃO MAJORANTE EM CRIANÇAS DE EDUCAÇÃO INFANTIL: um estudo de caso
Authors: Teixeira Adriano Canabarro , Furini Caroline da Silva , Caimi Flávia Eloisa
Published: December 2018

A programação de computadores é uma competência técnica com potencial para o desenvolvimento cognitivo humano. Nesse sentido, é fundamental que seja explorada sua aplicabilidade no contexto da educação infantil, tema raro na produção científica na área de Educação. Assim, o estudo objetivou identificar a relação entre o conceito de equilibração majorante de Piaget com as atividades de programação de computadores realizadas por crianças da educação infantil participantes do Projeto Berçário de Hackers. Os procedimentos metodológicos utilizados constituíram-se de pesquisa qualitativa, com abordagem de pesquisa-ação, envolvendo observação participante nas oficinas e videogravações. O trabalho de campo foi desenvolvido com 19 crianças de cinco e seis anos, sendo selecionados dois estudantes para uma análise mais detida. Os resultados apontam para a presença de indícios de equilibração majorante, manifestadaem regulações ativas e automáticas.
Em defesa da divisão do trabalho científico: o debate Treves-Bobbio e a institucionalização da sociologia do direito na Itália
Authors: Konzen Lucas P. , Renner Marjorie C.
Published: January 2019

Resumo: Este artigo analisa o debate entre Renato Treves e Norberto Bobbio acerca da sociologia do direito, com foco nos textos que apareceram nos primeiros números do periódico italiano Sociologia del diritto (1974-1975). Busca-se compreender como as relações entre a sociologia do direito e a dogmática jurídica eram vislumbradas no momento em que transcorria a institucionalização de uma comunidade sociojurídica na Itália. Para Treves e Bobbio a sociologia do direito significou um modelo de estudo científico do fenômeno jurídico capaz de dar conta de problemas de pesquisa relacionados às funções do direito no Estado social, em um contexto de mudanças sociais que evidenciavam as limitações das perspectivas do positivismo jurídico e do estrutural-funcionalismo. No entanto, ao invés de defenderem uma ruptura com a análise estrutural do direito que caracteriza o positivismo jurídico, Treves e Bobbio convergiram na defesa da coexistência da sociologia do direito com a dogmática jurídica em um esquema de divisão do trabalho científico. Tal posição teórica abriu espaço para a institucionalização da sociologia do direito nas faculdades de direito italianas.Palavras-chave: História do pensamento jurídico. Sociologia do direito. Itália. Renato Treves. Norberto Bobbio.
A insuficiência de diferenciação funcional observada a partir da crise no cenário brasileiro
Authors: Souza Matheus Figueiredo Nunes de , Tonet Fernando
Published: January 2019

O presente trabalho tem como objeto promover uma descrição dos sistemas sociais a partir do cenário brasileiro utilizando a teoria dos sistemas sociais de Niklas Luhmann. A fim de cumprir com tal proposta, o objetivo deste artigo é constatar se o sistema do Direito sofre interferências do ambiente externo que podem afetar seus processos decisórios. O problema de pesquisa proposto é identificar se existe uma insuficiência de diferenciação funcional do sistema do Direito no Brasil. A hipótese de pesquisa a ser testada refere que tal insuficiência existe e é ocasionada em virtude das constantes interferências por elementos políticos e econômicos. O método de pesquisa utilizado foi o hipotético dedutivo, e as técnicas de pesquisa utilizadas foram a de pesquisa bibliográfica, fichamentos, categorias e conceitos operacionais. As conclusões parciais indicam que a hipótese se mostra verdadeira, indicando que no Brasil não existe uma completa diferenciação funcional do sistema do Direito.
MOTIVATIONAL FACTORS OF THE COLLABORATIVE CONSUMPTION IN THE ERA OF SHARING ECONOMY
Authors: Mayasari Iin , Haryanto Handrix Chris
Published: January 2019

The aim of this study was to analyze the motivational factors of collaborative consumption in the era of the sharing economy, as a part of consumers’ behavior by online media platforms. Collaborative consumption is about people’s willingness to share and to collaborate to meet certain needs. The study used the qualitative method with interviews for the data’s collection. The context of the study was using consumers who had experience of using Airbnb, Go-Jek, and selling their product via online media. Twenty-four respondents were obtained for the interviews. The length of each interview was approximately 1.5 hours. The analysis of this shifting consumption across its different facets provided an analysis of the motivational aspect of sharing resources, and the change in consumer consumption patterns. The motivational research examined the underlying reasons for consumers to act, and to undertake collaborative consumption; home sharing and selling second-hand goods were analyzed from the perspectives of their economic aspects, utility reasons, social orientation, emotional aspects, ecological aspects and personal values.
EFFECT OF PYROLYSIS TEMPERATURES ON COMPOSITION AND ELECTRICAL CONDUCTIVITY OF CARBOSIL PREPARED FROM RICE HUSK
Authors: Simanjuntak Wasinton , Sembiring Simon , Sebayang Kerista
Published: January 2019

The objective of this study was to evaluate the effect of pyrolysis temperatures on composition and electrical conductivity of carbosil produced from rice husk, by conducting pyrolysis experiments at three different temperatures of 200; 400; and 700 °C. The structure of the samples was characterized using Fourier Transform Infrared (FTIR) Spectroscopy and X-Ray Diffraction (XRD). The microstructure and elemental composition were characterized using Scanning Electron Microscopy/Energy Dispersive Spectroscopy (SEM/EDS), and the electrical conductivity was measured using four probe method. The FTIR analyses revealed the existence of Si-O-Si and Si-OH functional groups, but no functional groups associated with carbon, confirming the formation of carbosil. This formation of carbosil is also supported by the results of EDS analyses which show the presence of only three elements of C, O, and Si, respectively. The XRD results indicate that the carbosils are amorphous, suggesting that no transformation of carbon and silica into crystalline phase to the limit of the temperatures applied. The carbosil formation decreased with increasing of pyrolysis temperature. The microstructure of the carbosils indicates that the higher the temperature, the smaller the grain size of the samples. The values of electrical conductivity of the samples are in the range of 1.13 x 10-3 to 6.81 x 10-3/(Ω.m) with the application of 10 tones compression pressure, but the conductivities of the sample prepared at 200 °C were found to increase with increased compression pressure to six fold from 6.81 x 10-3 to 41.94 x 10-3/(Ω.m) by increasing compression pressure to 80 tones. Based on these conductivity values, the samples are considered as semiconductor, suggesting the potential use of the carbosil in semiconductor devices.
MAPPING OF ELECTROCHEMISTRY AND NEURAL NETWORK MODEL APPLIED IN STATE OF CHARGE ESTIMATION FOR LEAD ACID BATTERY USED IN ELECTRIC VEHICLE
Authors: Kaloko Bambang Sri , Soebagio Soebagio , Purnomo Mauridhi H.
Published: January 2019

Analytical models have been developed to diminish test procedures for product realization, but they have only been partially successful in predicting the performance of battery systems consistently. The complex set of interacting physical and chemical processes within battery systems has made the development of analytical models of significant challenge. Advanced simulation tools are needed to be more accurately model battery systems which will reduce the time and cost required for product realization. As an alternative approach begun, the development of cell performance modeling using non-phenomenological models for battery systems were based on artificial neural networks (ANN) using Matlab 7.6.0(R2008b). ANN has been shown to provide a very robust and computationally efficient simulation tool for predicting state of charge for Lead Acid cells under a variety of operating conditions. In this study, the analytical model and the neural network model of lead acid battery for electric vehicle were used to determinate the battery state of charge. A precision comparison between the analytical model and the neural network model has been evaluated. The precise of the neural network model has error less than 0.00045 percent.
SYNTHESIS 7-HYDROXY-3’,4’-DIMETHOXYISOFLAVON FROM EUGENOL
Authors: Alimuddin Andi Hairil , Mardjan Muhammad Idham Darussalam , Matsjeh Sabirin , Anwar Chairil , Mustofa Mustofa , Sholikhah Eti Nurwening
Published: January 2019

Eugenol from the isolation of clove leaves oil had been utilized in the synthesis of 7-hydroxy-3',4'-dimethoxy-isoflavone based on deoxybenzoin intermediate. The raw material was firstly converted into methyleugenol using DMS (89.87%). Secondly, methyl eugenol was oxidized using KMnO4 to produce 3,4-dimethoxybenzyl carboxylic acid (21%). Friedel-Craft acylation of it with recorcinol produced 3,4-dimethoxybenzyl-2',4'-dihydroxyphenyl ketone (deoxybenzoin intermediate) in 78% yield. Eventually, cyclization of the intermediate with reagents of BF3.OEt2/DMF/POCl3 yielded 7-hydroxy-3',4'-isoflavone in 85% yield.