bluuebunny/crossref_metadata_2025 huggingface dataset:
Conclusion: Care and Resilience in the Face of Increasing Precarity – COVID-19 and Beyond
Authors: Khorana Sukhmani
Published: September 2023

In addition to summarising the key findings from the previous six chapters of the book, this concluding chapter is a call for solidarities across differences to enable care as a culturally inflected emotional framework that governs all our relations with others. It argues that in times of increasing socio-economic precarity due to neoliberal policies and public health emergencies, and their amplification of racial divides, there are instances where the embodied capacities of care are working for collective change. Examples of this include migrants and refugees demonstrating their agency through a range of food-based social enterprises servicing the elderly, the sick and stranded overseas students during the COVID-19 pandemic.
Digital Frontiers in Gender and Security
Authors: Henshaw Alexis
Published: September 2023

Exploring the digital frontiers of feminist international relations, this book investigates how gender can be mainstreamed into discourse about technology and security.
With a focus on big data, communications technology, social media, cryptocurrency, and decentralized finance, the book explores the ways in which technology presents sites for gender-based violence. Crucially, it examines potential avenues for resistance at these sites, especially regarding the actions of major tech companies, surveillance by repressive governments, and attempts to use the Global South as a laboratory for new interventions.
The book draws valuable insights which will be essential to researchers in International Relations, Security Studies, and Feminist Security Studies.
How Guatemala Defied the Odds
Authors: Schwartz Rachel A. , Isaacs Anita
Published: September 2023

Abstract: Guatemala has experienced sustained democratic backsliding, including the manipulation of the 2023 electoral playing field. Yet, against the odds, Guatemalan citizens defied the ruling regime's electoral authoritarian strategy, voting an anticorruption reformer into power. This article analyzes Guatemala's (anti)democratic trajectory and explains how opposition actors resisted further backsliding during the 2023 electoral process. The authors argue that the Guatemalan regime reflects a "criminal oligarchy," and examine how rule-of-law advances prompted elite backlash that eviscerated democratic institutions. The unexpected 2023 electoral outcome, however, illustrates the possibilities of exploiting fissures in the criminal-oligarchic coalition to arrest authoritarian consolidation.
The Danger of Runaway AI
Authors: Davidson Tom
Published: September 2023

Abstract: We must reduce harms from current AI systems while also looking ahead to harms that may occur soon. Experts worry that runaway AI could cause extreme harm in the next five to twenty years. The risk is that we develop superhuman AI systems that surpass humans in domains like persuasion, strategy, hacking, and research and development; that we design these systems to pursue goals autonomously; that we accidentally give them unintended goals; and that humans lose control of these superhuman systems. Without regulation, the actions of a small number of elite AI developers could pose massive risks to the rest of society. The risk is not specific to any particular deployment context, but is inherent to the technology itself. So, in addition to regulating specific AI products, we should also regulate the development of frontier AI systems. We should develop safety standards and empower a regulatory authority to enforce them. These regulations would apply only to a small number of frontier AI developers. The risk from runaway AI could emerge very suddenly, especially if advanced AI itself has accelerated the pace of AI progress. If we wait to see the problem before responding, the regulations may come into force too late. So we should regulate proactively, requiring a government license for frontier AI developers.
Bond model of second harmonic generation in tetragonal and orthorhombic perovskite structures
Authors: Hardhienata Hendradi , Al Kharfan Hasan , Faci Salim , Birowosuto Muhammad Danang , Alatas Husin
Published: September 2023

We apply the simplified-bond-hyperpolarizability model (SBHM) to investigate second harmonic generation (SHG) from tetragonal and orthorhombic methylammonium (MA) lead (Pb) iodide (I) perovskite structures. Assuming that the SHG radiation comes from the anharmonic charges parallel to the Pb-I covalent bond vectors, we show explicitly how the reflective rotational anysotropy SHG (RASHG) intensity profiles arise via dipole superposition from the perovskite surface and that their bulk contribution is zero for both the tetragonal and orthorhombic bulk structures if the contribution from MA molecules can be neglected. In addition, we compare the third order susceptibility tensor obtained from group theory and SBHM and calculate the values for the nonzero components as well as derive the SHG intensity field formulas. We found that the tetragonal and orthorhombic perovskite SHG intensity profiles are different. Furthermore, our results show that even in relative complex systems such as metal halide perovskites (MHPs), RASHG experimental data can be fitted using only one independent fitting parameter, which is the effective Pb-I nonlinear hyperpolarizability. Therefore, the analysis of perovskite using an anharmonic bond model can lead to better efficiencies of photovoltaic devices, while it will also pave a way for the use of SHG in MHP crystals as frequency conversion and optical signal processing.
Compact high-resolution spectrometer based on super-prism and local-super-collimation effects of photonic crystal
Authors: Qi Xingchao , Chen Jingguang , Guan Fang , Shi Lei , Li Yunlin , Liu Yufu , Xiong Langlang , Lai Zhen , Wang Xianjun , Jiang Xunya
Published: September 2023

We propose a design of the compact high-resolution photonic crystal (PhC) spectrometer with a wide working bandwidth based on both super-prism and local-super-collimation (LSC) effects. The optimizing methods, finding the ideal incident angle and oblique angle of PhC for a wider working bandwidth and ideal incident beam width and PhC size for a certain resolution requirement, are developed. Besides the theoretical work, for the first time, the experiment of such a PhC spectrometer is conducted in the microwave frequency range, and the beam-splitting effects for different frequencies in a wide working bandwidth agree very well with the theoretical predictions. According to the scalability, with the condition to control the deviations in the fabrication processes the design could be extended to optical frequency ranges, e.g., infrared, visible-light, and ultraviolet ranges. The spectrometer in optical frequencies can be implemented on silicon-on-insulator (SOI) chips as a thin-slab structure so that the operating bandwidth can be expanded further through the multi-layer design. Theoretically, the size of the ultra-high-resolution PhC spectrometer in optical frequency ranges based on our design could be two orders smaller than the traditional design.
Resolving an inverse problem through a momentum flow within the framework of electromagnetic scattering
Authors: Ding Yi , Zhao Daomu
Published: September 2023

Although there have been many approaches to inverse problem in the classic theory of potential scattering, they are implicitly confined to the analysis of the scattered electric field, and thus the magnetic counterpart of the scattered wave is ignored, which limits the further application of those approaches to some extent. Here, we propose a new, to the best of our knowledge, technique for an inverse problem within the framework of electromagnetic scattering. This technique aims at reconstructing the correlation function of the scattering potential of a random medium through measuring the electromagnetic momentum flow of the scattered field in the far zone. As illustrative examples, we use the technique to determine the correlation functions of the scattering potentials of homogeneous, isotropic, and Gaussian-correlated spheres. Our new inversion approach works both microscopically and macroscopically.
Spatial and Temporal Expression of Ectodysplasin-A Signaling Pathway Members During Mandibular Condylar Development in Postnatal Mice
Authors: Xing Ludan , Liu Yuan , Wu Jiayan , Song Chenyu , Jiang Beizhan
Published: September 2023

A growing body of evidence emerging supported that ectodysplasin-A (EDA) signaling pathway contributed to craniofacial development. However, their expression in condyle has not been elucidated yet. This study investigated the expression patterns of EDA, EDA receptor (EDAR), and EDAR-associated death domain (EDARADD) in condyle of postnatal mice. Histological staining and micro–computed tomography (CT) scanning showed that as endochondral ossification proceeded, the thickness of chondrocyte layer decreased, and the volume of mandibular condyle increased. Osteoclasts remained active throughout the condylar development. Immunohistochemistry staining demonstrated that EDA was expressed in almost all layers during the first 2 weeks after birth. EDA shifted from the mature and hypertrophic layers to fibrous and proliferating layers at postnatal 3 weeks. As condyle matured, the distribution of EDA tended to be limited to hypertrophic layer. The distribution patterns of EDAR and EDARADD were consistent with EDA, while the level of EDAR expression was slightly lower. mRNA expression levels of EDA signaling pathway-related components increased after birth. Furthermore, we evaluated the expression of EDA using ATDC5 in vitro. EDA increased during the late stage of chondrogenesis. These findings proved that EDA signaling pathway was involved in condylar development and acted as a regulatory factor in condylar maturation and differentiation.
Personalized prediction for multiple chronic diseases by developing the multi-task Cox learning model
Authors: Zhang Shuaijie , Yang Fan , Wang Lijie , Si Shucheng , Zhang Jianmei , Xue Fuzhong
Published: September 2023

Personalized prediction of chronic diseases is crucial for reducing the disease burden. However, previous studies on chronic diseases have not adequately considered the relationship between chronic diseases. To explore the patient-wise risk of multiple chronic diseases, we developed a multitask learning Cox (MTL-Cox) model for personalized prediction of nine typical chronic diseases on the UK Biobank dataset. MTL-Cox employs a multitask learning framework to train semiparametric multivariable Cox models. To comprehensively estimate the performance of the MTL-Cox model, we measured it via five commonly used survival analysis metrics: concordance index, area under the curve (AUC), specificity, sensitivity, and Youden index. In addition, we verified the validity of the MTL-Cox model framework in the Weihai physical examination dataset, from Shandong province, China. The MTL-Cox model achieved a statistically significant (p<0.05) improvement in results compared with competing methods in the evaluation metrics of the concordance index, AUC, sensitivity, and Youden index using the paired-sample Wilcoxon signed-rank test. In particular, the MTL-Cox model improved prediction accuracy by up to 12% compared to other models. We also applied the MTL-Cox model to rank the absolute risk of nine chronic diseases in patients on the UK Biobank dataset. This was the first known study to use the multitask learning-based Cox model to predict the personalized risk of the nine chronic diseases. The study can contribute to early screening, personalized risk ranking, and diagnosing of chronic diseases.
A platform-independent framework for phenotyping of multiplex tissue imaging data
Authors: Ahmadian Mansooreh , Rickert Christian , Minic Angela , Wrobel Julia , Bitler Benjamin G. , Xing Fuyong , Angelo Michael , Hsieh Elena W. Y. , Ghosh Debashis , Jordan Kimberly R.
Published: September 2023

Multiplex imaging is a powerful tool to analyze the structural and functional states of cells in their morphological and pathological contexts. However, hypothesis testing with multiplex imaging data is a challenging task due to the extent and complexity of the information obtained. Various computational pipelines have been developed and validated to extract knowledge from specific imaging platforms. A common problem with customized pipelines is their reduced applicability across different imaging platforms: Every multiplex imaging technique exhibits platform-specific characteristics in terms of signal-to-noise ratio and acquisition artifacts that need to be accounted for to yield reliable and reproducible results. We propose a pixel classifier-based image preprocessing step that aims to minimize platform-dependency for all multiplex image analysis pipelines. Signal detection and noise reduction as well as artifact removal can be posed as a pixel classification problem in which all pixels in multiplex images can be assigned to two general classes of either I) signal of interest or II) artifacts and noise. The resulting feature representation maps contain pixel-scale representations of the input data, but exhibit significantly increased signal-to-noise ratios with normalized pixel values as output data. We demonstrate the validity of our proposed image preprocessing approach by comparing the results of two well-accepted and widely-used image analysis pipelines.
Cell cycle-dependent organization of a bacterial centromere through multi-layered regulation of the ParABS system
Authors: Kaljević Jovana , Tesseur Coralie , Le Tung B. K. , Laloux Géraldine
Published: September 2023

The accurate distribution of genetic material is crucial for all organisms. In most bacteria, chromosome segregation is achieved by the ParABS system, in which the ParB-bound parS sequence is actively partitioned by ParA. While this system is highly conserved, its adaptation in organisms with unique lifestyles and its regulation between developmental stages remain largely unexplored. Bdellovibrio bacteriovorus is a predatory bacterium proliferating through polyploid replication and non-binary division inside other bacteria. Our study reveals the subcellular dynamics and multi-layered regulation of the ParABS system, coupled to the cell cycle of B. bacteriovorus. We found that ParA:ParB ratios fluctuate between predation stages, their balance being critical for cell cycle progression. Moreover, the parS chromosomal context in non-replicative cells, combined with ParB depletion at cell division, critically contribute to the unique cell cycle-dependent organization of the centromere in this bacterium, highlighting new levels of complexity in chromosome segregation and cell cycle control.
Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons
Authors: Nishida Kazuhiko , Matsumura Shinji , Uchida Hitoshi , Abe Manabu , Sakimura Kenji , Badea Tudor Constantin , Kobayashi Takuya
Published: September 2023

The spinal dorsal horn comprises heterogeneous neuronal populations, that interconnect with one another to form neural circuits modulating various types of sensory information. Decades of evidence has revealed that transcription factors expressed in each neuronal progenitor subclass play pivotal roles in the cell fate specification of spinal dorsal horn neurons. However, the development of subtypes of these neurons is not fully understood in more detail as yet and warrants the investigation of additional transcription factors. In the present study, we examined the involvement of the POU domain-containing transcription factor Brn3a in the development of spinal dorsal horn neurons. Analyses of Brn3a expression in the developing spinal dorsal horn neurons in mice demonstrated that the majority of the Brn3a-lineage neurons ceased Brn3a expression during embryonic stages (Brn3a-transient neurons), whereas a limited population of them continued to express Brn3a at high levels after E18.5 (Brn3a-persistent neurons). Loss of Brn3a disrupted the localization pattern of Brn3a-persistent neurons, indicating a critical role of this transcription factor in the development of these neurons. In contrast, Brn3a overexpression in Brn3a-transient neurons directed their localization in a manner similar to that in Brn3a-persistent neurons. Moreover, Brn3a-overexpressing neurons exhibited increased axonal extension to the ventral and ventrolateral funiculi, where the axonal tracts of Brn3a-persistent neurons reside. These results suggest that Brn3a controls the soma localization and axonal extension patterns of Brn3a-persistent spinal dorsal horn neurons.
The solution structure of the unbound IgG Fc receptor CD64 resembles its crystal structure: Implications for function
Authors: Hui Gar Kay , Gao Xin , Gor Jayesh , Lu Jinghua , Sun Peter D. , Perkins Stephen J.
Published: September 2023

FcγRI (CD64) is the only high-affinity Fcγ receptor found on monocytes, macrophages, eosinophils, neutrophils and dendritic cells. It binds immunoglobulin G (IgG) antibody-antigen complexes at its Fc region to trigger key immune responses. CD64 contains three immunoglobulin-fold extracellular domains (D1, D2 and D3) and a membrane-spanning region. Despite the importance of CD64, no solution structure for this is known to date. To investigate this, we used analytical ultracentrifugation, small-angle X-ray scattering, and atomistic modelling. Analytical ultracentrifugation revealed that CD64 was monomeric with a sedimentation coefficient s020,w of 2.53 S, together with some dimer. Small-angle X-ray scattering showed that its radius of gyration RG was 3.3–3.4 nm and increased at higher concentrations to indicate low dimerization. Monte Carlo modelling implemented in the SASSIE-web package generated 279,162 physically-realistic trial CD64 structures. From these, the scattering best-fit models at the lowest measured concentrations that minimised dimers revealed that the D1, D2 and D3 domains were structurally similar to those seen in three CD64 crystal structures, but showed previously unreported flexibility between D1, D2 and D3. Despite the limitations of the scattering data, the superimposition of the CD64 solution structures onto crystal structures of the IgG Fc-CD64 complex showed that the CD64 domains do not sterically clash with the IgG Fc region, i.e. the solution structure of CD64 was sufficiently compact to allow IgG to bind to its high-affinity Fcγ receptor. This improved understanding may result in novel approaches to inhibit CD64 function, and opens the way for the solution study of the full-length CD64-IgG complex.
Continuing professional development opportunities for Australian endorsed for scheduled medicines podiatrists—What’s out there and is it accessible, relevant, and meaningful? A cross-sectional survey
Authors: Martin Saraid E. , Graham Kristin , Banwell Helen A. , Johnson Jacinta L.
Published: September 2023

Background

Non-medical prescribing is a valuable strategy to enable equitable access to medications in the context of the increasing demands on health services globally. Australian podiatrists have been able to seek endorsement for scheduled medicines (ESM) for over a decade. This project investigates the perceptions and habits of ESM podiatrists in meeting the extra continuing professional development (CPD) requirements associated with their ESM status.

Methods

Australian ESM podiatrists completed an anonymous, online survey capturing demographics; CPD engagement; and self-reflections of CPD activities.

Results

Twenty percent (n = 33) of Australian ESM registered podiatrists (N = 167) responded to the survey (18 female; median ESM status 2.5 years, (IQR 1.0, 9.0)). For the previous registration period, 88% (n = 29) completed the mandatory CPD hours, with only 35% (n = 11) completing a CPD learning goal plan. Over 80% identified their last ESM CPD activity as accessible, affordable, and could recommend to colleagues. Conversely, 50% or less agreed the activity increased confidence; changed their practice; improved communication skills; or enabled networking. Most respondents (81%, n = 27) indicated improvements should be made to the content, relevance, accessibility, and meaningfulness of CPD. These findings were supported by responses to the open-ended questions.

Conclusions

Our findings suggest ESM podiatrists engage in CPD that is accessible rather than learning goal driven. Concerningly, CPD activities resulted in low translation of learnings to practice. This brings in to question the value of mandatory CPD systems based on minimum hours, rather than meaningfulness.
Comparative analysis of the complete chloroplast genome of Papaveraceae to identify rearrangements within the Corydalis chloroplast genome
Authors: Kim Sang-Chul , Ha Young-Ho , Park Beom Kyun , Jang Ju Eun , Kang Eun Su , Kim Young-Soo , Kimspe Tae-Hee , Kim Hyuk-Jin
Published: September 2023

Chloroplast genomes are valuable for inferring evolutionary relationships. We report the complete chloroplast genomes of 36 Corydalis spp. and one Fumaria species. We compared these genomes with 22 other taxa and investigated the genome structure, gene content, and evolutionary dynamics of the chloroplast genomes of 58 species, explored the structure, size, repeat sequences, and divergent hotspots of these genomes, conducted phylogenetic analysis, and identified nine types of chloroplast genome structures among Corydalis spp. The ndh gene family suffered inversion and rearrangement or was lost or pseudogenized throughout the chloroplast genomes of various Corydalis species. Analysis of five protein-coding genes revealed simple sequence repeats and repetitive sequences that can be potential molecular markers for species identification. Phylogenetic analysis revealed three subgenera in Corydalis. Subgenera Cremnocapnos and Sophorocapnos represented the Type 2 and 3 genome structures, respectively. Subgenus Corydalis included all types except type 3, suggesting that chloroplast genome structural diversity increased during its differentiation. Despite the explosive diversification of this subgenus, most endemic species collected from the Korean Peninsula shared only one type of genome structure, suggesting recent divergence. These findings will greatly improve our understanding of the chloroplast genome of Corydalis and may help develop effective molecular markers.
Effects measurement and spatial differentiation in synergy between pollution and carbon reduction in national urban agglomerations
Authors: Feng Peijiong , Lu Tianyun , Yu Yaguai , Gao Ruiyan , Ni Taohan
Published: September 2023

Five national urban agglomerations are selected according to the Fourteenth Five-Year Plan, namely the Yangtze River Delta, the Pearl River Delta, Beijing-Tianjin-Hebei, the Middle reaches of the Yangtze River, and Chengdu-Chongqing. The study on synergistic effects of such national strategic planning urban agglomerations, defined as coordinated degrees, and their time-series trends from 2016 to 2021 is significant for the practice of the national "double carbon" goal. Spatial differentiation of coordinated degree in five agglomerations is analyzed based on the Theil Index, along with regional linkage strength of coordinated degree under the gravity model. Conclusions include: (1) a downward trend is shown from 2016 to 2021 for the coordinated degree, along with the Pearl River Delta is the best among the five agglomerations; (2) the Middle reaches of the Yangtze River is the highest, followed by the Pearl River Delta and the Yangtze River Delta of coordinated degree in 2021; (3) the main cause of downwards in coordinated degree combined by a stable decline in carbon emissions and fluctuating increase in pollutants; (4) intra-regional differences in the Yangtze River Delta and the Middle reaches of the Yangtze River are relatively large, compared with the smallest in the Pearl River Delta measured by Theil Index; (5) coefficients of variation are relatively higher in the Middle reaches of the Yangtze River and the Yangtze River Delta, followed by the Beijing-Tianjin-Hebei, the Pearl River Delta and Sichuan-Chongqing urban. Consequently, countermeasures are proposed from the perspective of government, including technology and regional cooperation, policy innovation by overall coordination, synergy promotion by technological innovation, and regional synergy by win-win cooperation.
The effect of ascertainment on penetrance estimates for rare variants: Implications for establishing pathogenicity and for genetic counselling
Authors: Paterson Andrew D. , Seok Sang-Cheol , Vieland Veronica J.
Published: September 2023

Next-generation sequencing has led to an explosion of genetic findings for many rare diseases. However, most of the variants identified are very rare and were also identified in small pedigrees, which creates challenges in terms of penetrance estimation and translation into genetic counselling in the setting of cascade testing. We use simulations to show that for a rare (dominant) disorder where a variant is identified in a small number of small pedigrees, the penetrance estimate can both have large uncertainty and be drastically inflated, due to underlying ascertainment bias. We have developed PenEst, an app that allows users to investigate the phenomenon across ranges of parameter settings. We also illustrate robust ascertainment corrections via the LOD (logarithm of the odds) score, and recommend a LOD-based approach to assessing pathogenicity of rare variants in the presence of reduced penetrance.
Predictors of underweight among adult patients receiving antiretroviral therapy in Bishoftu general hospital, central Ethiopia: Case-control study
Authors: Assefa Mesfin Gashaw , Deksisa Alem , Abdo Mariama , Alemayehu Obse Tamiru , Daka Dawit Wolde
Published: September 2023

Background

Underweight affects the overall clinical outcome and quality of life and increases the risk of mortalities in Human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) patients. Though studies have examined the various determinants of being underweight in people living with HIV/AIDS (PLHIV), scanty evidence exists about the influence of dietary diversity scores and dietary counseling on underweight HIV patients in Ethiopia. This study aimed to identify the determinants of being underweight among adult patients receiving antiretroviral therapy at Bishoftu General Hospital, central Ethiopia.

Methods

An institution-based unmatched case-control study was conducted among 279 participants (93 cases and 186 controls) from April to May 2022. Cases were selected consecutively as they occur, and then two subsequent controls that visited the antiretroviral therapy(ART) clinic were interviewed until the sample size was attained. Data were collected using a pretested structured questionnaire and involved patient interviews and chart review. Bivariate and Multivariable logistic regression was used to identify determinants of underweight. The presence of statistically significant association was declared with p-value <0.05, and a 95% confidence interval was used to show the precision in the measure of the strength of association.

Results

The response rate of participants was 91.2% for each of the cases and controls. Monthly income of patients ≤2000 birr (AOR = 6.63, 95% CI: 2.96–14.85), absence of support giver (AOR = 3.22, 95% CI: 1.38–7.50), being having an eating problem (AOR = 14.48, 95% CI: 5.06–41.40), dietary diversity score of four to five (AOR = 2.36, 95% CI: 1.92, 6.08), not getting dietary counseling support and advice (AOR = 2.53, 95% CI: 1.11, 5.72) and chewing khat (AOR = 3.36, 95% CI: 1.99,11.33) were determinants of underweight in adult HIV patients.

Conclusions

This study revealed that household dietary diversity, counseling and education on nutrition, monthly income, eating problems, support giver, and khat chewing were predictors of being underweight in HIV patients. This inquires an integrated nutritional intervention including income-generating activities, counseling and education on nutrition and bad habits, and regular monitoring of the nutritional status during clinic visits.
The Brazilian National Oral Health Policy and oral cancer mortality trends: An autoregressive integrated moving average (ARIMA) model
Authors: Costa Elisa Miranda , Magalhães Rodrigues Elisa Santos , de Sousa Francenilde Silva , Pimentel Felipe Bezerra , Sodré Lopes Mariana Borges , Vissoci João Ricardo Nickenig , Thomaz Erika Barbara Abreu Fonseca
Published: September 2023

Objective

This study analyzes the effect of the Brazilian National Oral Health Policy (NOHP) on oral cancer mortality rates (OCMR).

Method

This is an ecological study with secondary oral cancer death data, using interrupted time series analysis (ARIMA, Autoregressive Integrated Moving Average). Annual death data were collected from the Mortality Information System (1996–2019). The outcome was the OCMR, standardized by gender and age We considered the NOHP, categorized as “0” (before its implementation), from 1996 to 2004, and “1 to 15”, from 2005 to 2019. ARIMA modeling was carried out for temporal analysis, and regression coefficient estimation (RC).

Results

The Brazilian NOHP implementation was associated with an increase in OCMR in the North region (CR = 0.16; p = 0.022) and with a decrease in the Southeast region (CR = -0.04; p<0.001), but did not affect the other macro-regions nor Brazil. The forecast models estimated an increase in OCMR for the North, and Northeast, a decrease for the Southeast, and stability for the South and Brazil.

Conclusion

The Brazilian NOHP is not being effective in reducing the OCMR. The trends behaved differently in the Brazilian territory, highlighting health inequities. We recommend that the NOHP strengthen the oral health care network, incorporating oral cancer as a notifiable disease, adopting strategies for prevention, screening, and providing opportunities for early treatment of the disease.
Influence of different treatment conditions on the filtration performance of conventional electret melt blown non-woven and novel nano FFP2 masks
Authors: Halamicek Robin , Wiesmann Carolin , Kröner Richard , Eber Matthias , Bogdan Christian , Schubert Dirk W.
Published: September 2023

To allow an efficient protection against viruses like the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), it is important to avoid their spreading by using filtering face pieces (FFP), which are categorized by different standards according to their filtration efficiency. In this study, we subjected six brands of FFP2 standard masks to three different conditions and subsequently analysed them for their filtration performance to evaluate potentials for reusability. The conditions comprised changes of temperature and air humidity, an exposure to isopropyl alcohol (IPA) and an autoclave sterilization. While four of six masks consisted of electrostatically treated melt blown non-wovens, two masks were fabricated using a nanofibrous multilayer system. Due to the absence of prior electrostatic treatment, the nano-masks did not show a significant change in filtration efficiency when discharged by IPA, unlike the melt blown nonwoven masks showing a significant decrease of filtration efficiency down to around 50% at a particle size of 0.3 μm. However, most melt blown masks maintained a sufficient filtration efficiency after all other treatments with even better results than the nanofibrous masks. This was particularly the case for the capacity to filter smallest particles/droplets with a size of around 0.1 μm, which is below the range of typical filtering standards and important for the retention of virally contaminated nano-aerosols or unattached viruses. After temperature/humidity variation and autoclave sterilization, melt blown masks were able to retain a filtration efficiency up to over 90% at 0.1 μm contrary to nano-masks showing a decrease down to around 70%. Based on their better filtration performance, lower price and potential reusability, we conclude that electret melt blown masks are the preferable type of FFP2 masks.
Financial crisis early warning of Chinese listed companies based on MD&A text-linguistic feature indicators
Authors: Zhang Zhishuo , Liu Xinran , Niu Huayong
Published: September 2023

Nowadays, the international situation is severe and complex, and the structural issues within the Chinese economy are prominent. Consequently, the financial risks faced by Chinese listed companies continue to escalate. Hence, it is of great practical significance to furnish effective early warnings for financial crises in listed companies. In this paper, we first employ web crawler technology and natural language processing technology to assess four text-linguistic features in the Management Discussion and Analysis (MD&A) section of the annual financial reports of listed companies in China from 2011 to 2020. These features are text tone, forward-looking, readability and similarity. Subsequently, we combine these features with traditional financial indicators and explore thirteen mainstream machine learning models to comparatively analyze their effectiveness in predicting financial crises in listed companies. The empirical findings of this research reveal that MD&A text readability and similarity indicators contribute valuable incremental information to prediction models, whereas text tone and forward-looking indicators exhibit the opposite effect. The latter two indicators can be manipulated more effortlessly by management, as this study’s empirical findings indicate no evidence of their contributions in incremental informational value. In fact, the forward-looking indicator even introduces additional noise to the prediction. Finally, by comparing the early warning effects of thirteen machine learning models, it is found that RF, Bagging, CatBoost, GBDT, XGBoost and LightGBM models maintain stable and accurate sample recognition ability. In general, this paper constructs a more effective financial crisis early warning model by exploring the MD&A text-linguistic feature indicators, thereby offering a fresh research perspective for further investigations in this field.
Optimizing digital implant impressions: Evaluating the significance of scan body image deficiency and alignment under varied scan body exposures
Authors: Petchmedyai Pobploy , Thanasrisuebwong Prakan
Published: September 2023

In implant dentistry, the advent of intraoral scanning technology has revolutionized traditional clinical processes by streamlining procedures and ensuring predictable treatment outcomes. However, achieving accurate virtual implant positions using intraoral scanners and scan bodies can be influenced by various clinical and laboratory factors. This study aims to investigate the impact of scan body image capture deficiency and scan body alignment methods in computer-aided design (CAD) software on the accuracy of virtual implant positions, particularly in different implant depths. Three stereolithographic half-arch implant models with different implant depths were prepared, representing three scenarios of scan body exposure: full exposed scan body, 2/3 exposed scan body, and 1/3 exposed scan body. The scan body image capture deficiency and alignment methods were simulated using CAD software. The deviation of virtual implant positions obtained from different scenarios were evaluated using 3D analysis software. The highest angular and linear deviation (0.237±0.059 degrees, 0.084±0.068 mm) were found in the 1/4 upper and lower part scan body deficiency using the 1-point alignment method in the 1/3 exposed scan body. Two-way ANOVA analysis revealed significant effects of scan deficiency on virtual implant position deviations across all scan body exposures, except for the linear deviation when the scan body was exposed 2/3 of its length. Furthermore, scan deficiencies in the 1/4 upper and lower parts of the scan body significantly affected implant angular deviation regardless of scan body exposure, while implant linear deviation was specifically affected when the scan body was exposed to only 1/3 of its total length. Deficiencies in scan body acquisition, particularly in deep soft tissue situations, can lead to deviations in both angular and linear positioning of virtual implants. Employing appropriate scan body alignment methods such as a 3-point alignment approach demonstrates better accuracy compared to a 1-point alignment.
Incidence of adverse cardiovascular events in patients with insomnia: A systematic review and meta-analysis of real-world data
Authors: Ali Eman , Shaikh Asim , Yasmin Farah , Sughra Fatima , Sheikh Ayesha , Owais Rabia , Raheel Hamna , Virk Hafeez Ul Hassan , Mustapha Jihad A.
Published: September 2023

Insomnia is a prevalent sleeping disorder associated with increasing cardiovascular (CV) mortality and morbidity. However, data incorporating recent clinical studies evaluating these outcomes is scarce. Hence, we aimed to investigate the association of insomnia with CV mortality, myocardial infarction (MI), all-cause mortality, and incidence of CV disease by conducting the first-ever meta-analysis of real-world data evaluating these CV outcomes. MEDLINE and Scopus databases were queried till August 2022 to identify studies comparing prespecified outcomes in patients with and without insomnia. The primary outcomes were CV mortality and myocardial infarction, while secondary outcomes included all-cause mortality, and CV-disease incidence. All data were pooled using an inverse-variance weighted random-effects model, and results were reported as relative risks (RRs) and p-values. 21 studies were analyzed. Risks for CV mortality and MI were significantly higher in patients with insomnia (RR 1.53, p<0.01, and RR 1.48, p = 0.03, respectively). The risk for all-cause mortality and CV disease incidence was also significantly higher in insomnia patients (RR 1.14, p = 0.03, and RR 1.31, p<0.01, respectively). Individuals with insomnia experience a higher risk of long-term mortality, MI, and incidence of CV disease.
Use of instructional videos in leadership education in higher education under COVID-19: A qualitative study
Authors: Shek Daniel T. L. , Wong Tingyin , Li Xiang , Yu Lu
Published: September 2023

The use of online teaching mode has grown rapidly in recent years, particularly under the COVID-19 pandemic. To promote the learning motivation of students and teaching effectiveness, development of attractive online teaching material such as videos is important. In the present study, we developed 15 theory-related videos and 9 case-based videos in the context of a leadership course focusing on psychological well-being and psychosocial competence. Using a qualitative research methodology via focus groups (N = 48 students) to evaluate these videos, six themes emerged from the data, including video arrangement, design of videos, content of videos, benefits to students’ pre-lesson self-learning, benefits to students’ learning of course content, and contribution to students’ class participation. The findings suggest that the videos can elicit positive perceptions of the students in a flipped classroom arrangement. Students also benefit from the videos in terms of their understanding of course content and their participation in class discussion. Besides, the study suggests that the videos promote the learning efficiency of the students. The present qualitative findings concurred with the previous quantitative findings, suggesting the value of using virtual teaching and learning to promote psychosocial competence in university students.
The so-called ligamentum arteriosum is innervated
Authors: Benedicta Quaye
Published: September 2023

The ductus arteriosus is a muscular artery connecting the pulmonary trunk directly to the aorta in fetal circulation in order to by-pass the fluid filled lungs. Post-natally, this vessel is speculated to undergo obliteration, fibrosis and ultimately metamorphosize into a band of ligament, thereby changing name from the ductus arteriosus to the ligamentum arteriosum (LA). Earlier studies into the innervation of the ductus arteriosus reported innervation from the left aortic and vagus nerves. However, information of what becomes of the innervation is scanty and contradictory. I hypothesized that; this fetal shunt still receives innervation even in post-uterine life. To test this, LA of human, pig, and wild-type mice were studied using double-immunofluorescence labeling using antibodies directed against structural and general neuronal marker proteins (Smooth muscle actin and Protein gene product 9.5 (PGP 9.5, respectively). Additionally, TEM studies were performed on mouse LA. Results from the present study demonstrates an extensive innervation of the LA in animals (mice and pigs) and in senescent humans validated by two independent methods, i.e., immunolabeling with antibody directed against PGP 9.5 and TEM. Intense immunoreactivity was clearly visible in samples subjected to PGP-immunolabeling. TEM revealed the presence of nerve terminals with about 30% of all nerve terminals observed less than 1 μm away from smooth muscle cells within the LA. This clearly differs from elastic arteries, where the distance between autonomic terminals and smooth muscle cells is rarely less than 1 μm. Conceivably, these results imply that the so- called LA receives innervation representative of that present within the ductus arteriosus during fetal life. This provides the first reliable study of innervation of the LA and makes room for further investigation into the neurochemistry of this innervation. This is crucial as the presence of nerve terminals may play a role in vessel compliance or impedance of the two great vessels related to this structure. The substances released by these fibers may also have an influence on cells and tissues in the immediate microenvironment of this structure.
Feasibility of mitigating out-toeing gait using compression tights with inward-directing taping lines
Authors: Pathak Prabhat , Kim Hye Suk , Kim Hyunji , Park Juyeon , Lee Giuk , Ahn Jooeun
Published: September 2023

Out-toeing gait may cause alterations in lower limb biomechanics that could lead to an increased risk of overuse injuries. Surgery and physical therapy are conventional methods for mitigating such gait, but they are costly and time-consuming. Wearable devices like braces and orthoses are used as affordable alternatives, but they apply non-negligible stress on the skin. Haptic feedback-delivering shoes were also recently developed, but they require actuators and power sources. The purpose of our study is to develop compression tights with inward directing taping lines that apply compression to lower limb muscles and segments to facilitate inward rotation of the foot, overcoming the drawbacks of previous methods. These compression tights were manufactured to fit the average height, leg length, hip girth, and waist girth of South Korean females in their twenties. The efficacy of these compression tights was evaluated by comparing walking kinematics and user satisfaction of 12 female dancers with an out-toeing gait under three conditions: wearing tights with taping lines, tights without taping lines, and basic bicycle shorts. The foot rotation angles and joint kinematics were recorded using a pressure-pad treadmill and motion capture system, respectively. Multiple pairwise comparisons revealed that the compression tights with inward-directing lines significantly reduced foot rotation angles (up to an average of 20.1%) compared with the bicycle shorts (p = 0.002 and 0.001 for dominant and non-dominant foot, respectively) or the compression tights without taping lines (p = 0.005 and p = 0.001 for dominant and non-dominant foot, respectively). Statistical parametric mapping revealed significant main effects of the tight type on joint kinematics. Also, t-tests revealed that the participants reported significantly higher ratings of perceived functionality and usability on the compression tights with inward-directing taping lines. In conclusion, we developed a comfortable and practical apparel-type wearable and demonstrated its short-term efficacy in mitigating out-toeing gait.
Stoichiometric characteristics of woody plant leaves and responses to climate and soil factors in China
Authors: Duan Xiangguang
Published: September 2023

The main research content of the field of ecological stoichiometry is the energy of various chemical elements and the interaction between organisms and the environment throughout ecological processes. Nitrogen and phosphorus are the main elements required for the growth and development of plants and these also form the constituent basis of biological organisms. Both elements interact and jointly regulate the growth and development of plants, and their element ratios are an indication of the nutrient utilization rate and nutrient limitation status of plants. Previous research developed a general biogeography model of the stoichiometric relationship between nitrogen and phosphorus in plant leaves on a global scale. Further, it was shown that the relative rate of nitrogen uptake by leaves was lower than that of phosphorus, and the scaling exponent of nitrogen and phosphorus was 2/3. However, it is not clear how the stoichiometric values of nitrogen and phosphorus, especially their scaling exponents, change in the leaves of Chinese woody plants in response to changing environmental conditions. Therefore, data sets of leaf nitrogen and phosphorus concentrations, and nitrogen to phosphorus ratios in Chinese woody plants were compiled and classified according to different life forms. The overall average concentrations of nitrogen and phosphorus in leaves were 20.77 ± 8.12 mg g-1 and 1.58 ± 1.00 mg g-1, respectively. The contents of nitrogen and phosphorus in leaves of deciduous plants were significantly higher than those of evergreen plants. In leaves, life form is the main driving factor of nitrogen content, and mean annual temperature is the main driving factor of phosphorus content; soil available nitrogen is the main driving factor of the nitrogen to phosphorus ratio. These values can be used for comparison with other studies. In addition, the scale index was found to be significantly different among different life forms. The scaling exponents of N-P of woody plants of different life forms, such as trees, shrubs, evergreen, deciduous, and coniferous plants are 0.67, 0.72, 0.63, 0.72, and 0.66, respectively. The N-P scaling exponent of shrubs was higher than that of trees, and that of deciduous plants was higher than that of evergreen plants. These results suggest that the internal attributes of different life forms, the growth rate related to phosphorus, and the relative nutrient availability of soil are the reasons for the unsteady relationship between nitrogen and phosphorus in leaves.