bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulating the Impacts of Drought and Warming in Summer and Autumn on the Productivity of Subtropical Coniferous Forests
Authors: Xie Menglu , Zhu Yu , Liu Shuguang , Deng Deming , Zhu Liangjun , Zhao Meifang , Wang Zhao
Published: December 2022

The impacts of drought and/or warming on forests have received great attention in recent decades. Although the extreme drought and/or warming events significantly changed the forest demography and regional carbon cycle, the seasonality quantifying the impacts of these climate extremes with different severities on the productivity of subtropical coniferous forests remains poorly understood. This study evaluated the effects of seasonal drought and/or warming on the net primary productivity (NPP) of subtropical coniferous forests (i.e., Cunninghamia lanceolata and Pinus massoniana forests) from Hengyang–Shaoyang Basin in southern China using the Ecosystem Demography model, Version 2.2 (ED-2.2) and based on the datasets from forest inventory, meteorological reanalysis, and remotely sensed products. The results showed that the goodness of fit of the DBH-height allometric equations was better than that of the default in ED-2.2 after model calibration; the ED-2.2 model qualitatively captured the seasonality of NPP in the subtropical coniferous forests; and the mismatch between simulated annual NPP and MODIS-NPP (MOD17A3HGF) became smaller over time. The effect of seasonal drought on NPP was greater than that of warming; the decline rate of NPP gradually increased and decreased with time (from July to October) under the seasonal drought and warming scenarios, respectively; NPP decreased more seriously under the combined drought-warming scenario in October, with an average decrease of 31.72%, than the drought-only and warming-only scenarios; seasonal drought had an obvious legacy impact on productivity recovery of subtropical coniferous forests, but it was not the case for warming. With the increase in drought severity, the average values of soil available water and NPP together showed a downward trend. With the increase in warming severity, the average values of canopy air space temperature increased, but NPP decreased. Seasonal drought and/or warming limit forest production through decreasing soil moisture and/or increasing canopy air space temperature, which impact on plant photosynthesis and productivity, respectively. Our results highlight the significance of taking into account the impacts of seasonal warming and drought when evaluating the productivity of subtropical coniferous forests, as well as the significance of enhancing the resistance and resilience of forests to future, more severe global climate change.
Valorization of Fourth-Range Wastes: Evaluating Pyrolytic Behavior of Fresh and Digested Wastes
Authors: Martínez Elia Judith , González Rubén , Ellacuriaga Marcos , Gómez Xiomar
Published: December 2022

Changes in daily habits and a stressful lifestyle create modifications in consumer preferences and open opportunities to new market products. This is the case of fourth-range products in which the industrial sector generates a waste stream of high quality. Valorization of this type of waste as a single stream is desirable to avoid lowering quality with other low-grade materials. Anaerobic digestion of fourth-range wastes was studied under discontinuous and semi-continuous conditions. A high carbon content characterizes the organic material composed of fruit and vegetable wastes. The fast degradation of the substrate indicated no limitations associated with the hydrolysis stage, as observed from kinetic parameters estimated from batch assays. However, the easiness of degradation did not translate into short hydraulic retention times when operating under semi-continuous conditions. Additionally, the insufficient amount of nutrients prevented the development of a well-balanced digestion process. Specific methane production was 325 mL CH4/g VS added at a hydraulic retention time of 30 days. However, solid accumulation was observed at the end of the experiment, indicating that conditions established did not allow for the complete conversion of the organic material. Digestate evaluation using thermal analysis under inert conditions showed a thermal profile evidencing the presence of complex components and a high tendency to char formation.
Performance of Steel Bar Lap Splices at the Base of Seismic Resistant Reinforced Concrete Columns Retrofitted with FRPs—3D Finite Element Analysis
Authors: Anagnostou Evgenia , Rousakis Theodoros
Published: December 2022

This paper examines analytically the design criteria for the composite retrofit of reinforced concrete (RC) columns with a short lap splice length of steel rebars inside the critical region. The advanced potential of pseudo-dynamic three-dimensional (3D) finite element (FE) modelling is utilized to investigate critical design parameters for the required carbon fiber-reinforced polymer (FRP) jacketing of RC columns with a rectangular cross-section based on the experimental lateral force-to-drift envelope behavior of characteristic cases from the international literature. The satisfactory analytical reproduction of the experimental results allows for the systematic numerical investigation of the developed stress along the lap splice length. The maximum lateral force and the horizontal displacement ductility of the column, as well as the maximum developed tensile axial force on the longitudinal bars, their variation along the lap, the bar yielding, and the plastic hinge length variation, are considered to determine the seismic behavior of the columns. For the first time, cases of smooth bar slip together with delayed bar yielding or without bar yielding are identified that may be recorded through a “ductile” P-d seismic response. Such pseudo-ductile response cases are revisited through suitably revised redesign criteria for adequate FRP jacketing.
Factors Influencing Consumption Behaviour towards Aquatic Food among Asian Consumers: A Systematic Scoping Review
Authors: Budhathoki Mausam , Campbell Danny , Belton Ben , Newton Richard , Li Saihong , Zhang Wenbo , Little David
Published: December 2022

Asia accounts for over 70% of total global aquatic food consumption, but aquatic food consumption behaviours and attitudes among Asian consumers are poorly documented and understood. This paper synthesises literature on factors influencing aquatic food consumption behaviour in Asia and the potential to support transitions toward more sustainable food consumption patterns. We identified 113 studies for inclusion in a scoping review, and identified five clusters of publications: (1) product attributes, availability, and accessibility (24% of publications); (2) willingness to pay for aquatic foods (25%); (3) psychosocial factors (e.g., attitudes and subjective norms) (17%); (4) sociodemographic and lifestyle factors (21%); and (5) miscellaneous factors, including food safety and social status (13%). This study indicates that multiple interacting factors influence aquatic food consumption behaviours among Asian consumers, among which price is central. Knowledge of, and attitudes toward, the perceived quality and safety of aquatic foods were identified as important but were mediated by household characteristics. Sustainable production practices, country of origin, and ecolabels were found to be less influential on consumption behaviour. We found that improving consumers’ knowledge and attitudes about the quality and safety of aquatic foods might positively influence aquatic food consumption behaviour. Future multidisciplinary research is required to better understand interactions among the multiple factors that influence Asian consumers’ aquatic food consumption behaviour.
Investigation of the Structure and Allergic Potential of Whey Protein by Both Heating Sterilization and Simulation with Molecular Dynamics
Authors: Zhang Zhao , Ma Ruida , Xu Yunpeng , Chi Lei , Li Yue , Mu Guangqing , Zhu Xuemei
Published: December 2022

As the main allergens in milk, whey proteins are heat-sensitive proteins and are widespread in dairy products and items in which milk proteins are involved as food additives. The present work sought to investigate the effect of heating sterilization on the allergenicity of α-lactalbumin (α-LA) and β-lactoglobulin (β-LG), the main composite and allergen in whey protein isolate (WPI), by combining molecular dynamics with experimental techniques for detecting the spatial structure and IgE binding capacity. The structure of WPI was basically destroyed at heat sterilization conditions of 95 °C for 5 min and 65 °C for 30 min by SDS-PAGE analysis and spectroscopic analysis. In addition, α-lactalbumin (α-LA) may be more sensitive to temperature, resulting in exposure to allergic epitopes and increasing the allergic potential, while the binding capacity of β-lactoglobulin (β-LG) to IgE was reduced under 65 °C for 30 min. By the radius of gyration (Rg) and root-mean-square deviation (RMSD) plots calculated in molecular dynamics simulations, α-LA was less structurally stable at 368 K, while β-LG remained stable at higher temperatures, indicating that α-LA was more thermally sensitive. In addition, we observed that the regions significantly affected by temperatures were associated with the capacity of allergic epitopes (α-LA 80–101 and β-LG 82–93, 105–121) to bind IgE through root-mean-standard fluctuation (RMSF) plots, which may influence the two major allergens. We inferred that these regions are susceptible to structural changes after sterilization, thus affecting the allergenicity of allergens.
A Patient with Corticobasal Syndrome and Progressive Non-Fluent Aphasia (CBS-PNFA), with Variants in ATP7B, SETX, SORL1, and FOXP1 Genes
Authors: Gaweda-Walerych Katarzyna , Sitek Emilia J. , Borczyk Małgorzata , Narożańska Ewa , Brockhuis Bogna , Korostyński Michał , Schinwelski Michał , Siemiński Mariusz , Sławek Jarosław , Zekanowski Cezary
Published: December 2022

Our aim was to analyze the phenotypic-genetic correlations in a patient diagnosed with early onset corticobasal syndrome with progressive non-fluent aphasia (CBS-PNFA), characterized by predominant apraxia of speech, accompanied by prominent right-sided upper-limb limb-kinetic apraxia, alien limb phenomenon, synkinesis, myoclonus, mild cortical sensory loss, and right-sided hemispatial neglect. Whole-exome sequencing (WES) identified rare single heterozygous variants in ATP7B (c.3207C>A), SORL1 (c.352G>A), SETX (c.2385_2387delAAA), and FOXP1 (c.1762G>A) genes. The functional analysis revealed that the deletion in the SETX gene changed the splicing pattern, which was accompanied by lower SETX mRNA levels in the patient’s fibroblasts, suggesting loss-of-function as the underlying mechanism. In addition, the patient’s fibroblasts demonstrated altered mitochondrial architecture with decreased connectivity, compared to the control individuals. This is the first association of the CBS-PNFA phenotype with the most common ATP7B pathogenic variant p.H1069Q, previously linked to Wilson’s disease, and early onset Parkinson’s disease. This study expands the complex clinical spectrum related to variants in well-known disease genes, such as ATP7B, SORL1, SETX, and FOXP1, corroborating the hypothesis of oligogenic inheritance. To date, the FOXP1 gene has been linked exclusively to neurodevelopmental speech disorders, while our study highlights its possible relevance for adult-onset progressive apraxia of speech, which guarantees further study.
The Value of a Comprehensive Genomic Evaluation in Prenatal Diagnosis of Genetic Diseases: A Retrospective Study
Authors: Fu Fang , Li Ru , Yu Qiu-Xia , Dang Xiao , Yan Shu-Juan , Zhou Hang , Cheng Ken , Huang Rui-Bin , Wang You , Zhang Yong-Ling , Jing Xiang-Yi , Zhang Li-Na , Li Dong-Zhi , Liao Can
Published: December 2022

Currently, there are still many challenges in prenatal diagnosis, such as limited or uncertain fetal phenotyping, variant interpretation, and rapid turnaround times. The aim of this study was to illustrate the value of a comprehensive genomic evaluation in prenatal diagnosis. We retrospectively reviewed 20 fetuses with clinically significant copy number variants (CNVs) detected by chromosomal microarray analysis (CMA) and no further exome sequencing testing in our tertiary center between 2019 and 2020. The residual DNA from the prenatal cases was used for the parallel implementation of CNV sequencing (CNV-seq) and trio-based clinical exome sequencing (trio-CES). CMA revealed 26 clinically significant CNVs (18 deletions and eight duplications) in 20 fetuses, in which five fetuses had two or more CNVs. There were eight fetuses with pathogenic CNVs (e.g., del 1p36), nine fetuses with likely pathogenic CNVs (e.g., dup 22q11.21), and three fetuses with variants of unknown significance (VOUS, e.g., dup 1q21.1q21.2). Trio-CES identified four fetuses with likely pathogenic mutations (SNV/InDels). Of note, a fetus was detected with a maternally inherited hemizygous variant in the SLX4 gene due to a 16p13.3 deletion on the paternal chromosome. The sizes of CNVs detected by CNV-seq were slightly larger than that of the SNP array, and four cases with mosaic CNVs were all identified by CNV-seq. In conclusion, microdeletion/duplication syndromes and monogenic disorders may co-exist in a subject, and CNV deletion may contribute to uncovering additional recessive disease alleles. The application of a comprehensive genomic evaluation (CNVs and SNV/InDels) has great value in the prenatal diagnosis arena. CNV-seq based on NGS technology is a reliable and a cost-effective technique for identifying CNVs.
Spotlight on a Short-Time Treatment with the IL-4/IL-13 Receptor Blocker in Patients with CRSwNP: microRNAs Modulations and Preliminary Clinical Evidence
Authors: Mimmi Selena , Lombardo Nicola , Maisano Domenico , Piazzetta Giovanna , Pelaia Corrado , Pelaia Girolamo , Greco Marta , Foti Daniela , Dattilo Vincenzo , Iaccino Enrico
Published: December 2022

Already used for the treatment of some allergic and inflammatory diseases, such as asthma or atopic dermatitis, dupilumab has also been approved as add-on therapy for patients with CRSwNP, and it could represent the keystone to reducing the remission time as well as to improve healing and quality of life. On the other hand, the role of miRNAs as potential biomarkers of immune modulation is emerging. We analyzed the effects of a short-time treatment with dupilumab in patients with CRSwNP, analyzing the immune response modification as well as miRNAs modulations. First, in this early observation stage, all patients experienced remarkable improvement and were clinically stable. Indeed, we observed a significant decrease in CD4+ T cells and a significant reduction in total IgE (p < 0.05) and serum IL-8 levels (p < 0.01), indicating a reduction in the general inflammatory condition. In addition, we analyzed a panel of about 200 circulating miRNAs. After treatment, we noted a significant downregulation of hsa-mir-25-3p (p-value = 0.02415) and hsa-mir-185-5p (p-value = 0.04547), two miRNAs involved in the proliferation, inflammation, and dug-resistance, in accordance with the clinical status of patients. All these preliminary data aimed to identify new biomarkers of prognosis, identifiable with non-invasive procedures for patients. Further, these patients are still under observation, and others with different levels of responsiveness to treatment need to be enrolled to increase the statistical data.
Automatic Tsunami Hazard Assessment System: “Tsunami Observer”
Authors: Kolesov Sergey V. , Nosov Mikhail A. , Sementsov Kirill A. , Bolshakova Anna V. , Nurislamova Gulnaz N.
Published: December 2022

The current prototype of a fully automatic earthquake tsunami hazard assessment system, “Tsunami Observer”, is described. The transition of the system to the active phase of operation occurs when information about a strong earthquake (Mw ≥ 6.0) is received. In the first stage, the vector field of coseismic displacements of the Earth’s crust is calculated by using the Okada formulas. In the calculations, use is made of data on the coordinates, the seismic moment, the focal mechanism, and the depth of the earthquake, as well as empirical patterns. In the second stage, the initial elevation of the water surface at the tsunami’s focus is determined with the vector field of coseismic displacements of the bottom and the distribution of ocean depths, and the earthquake’s potential energy is calculated. In the third stage, the intensity of the tsunami is estimated on the Soloviev–Imamura scale in accordance with the magnitude of the potential energy by using the empirical relationship that is obtained as a result of a statistical analysis of historical tsunami events. In the final stage, if the energy exceeds the critical value of 109 J, a numerical simulation of the tsunami is performed, which allows the determination of the predominant directions of wave energy propagation and estimation of the runup height on the nearest coast. In this work, data on the operation of the system over the last 3 years are presented.
Accuracy of Vegetation Indices in Assessing Different Grades of Grassland Desertification from UAV
Authors: Xu Xue , Liu Luyao , Han Peng , Gong Xiaoqian , Zhang Qing
Published: December 2022

Grassland desertification has become one of the most serious environmental problems in the world. Grasslands are the focus of desertification research because of their ecological vulnerability. Their application on different grassland desertification grades remains limited. Therefore, in this study, 19 vegetation indices were calculated for 30 unmanned aerial vehicle (UAV) visible light images at five grades of grassland desertification in the Mu Us Sandy. Fractional Vegetation Coverage (FVC) with high accuracy was obtained through Support Vector Machine (SVM) classification, and the results were used as the reference values. Based on the FVC, the grassland desertification grades were divided into five grades: severe (FVC < 5%), high (FVC: 5–20%), moderate (FVC: 21–50%), slight (FVC: 51–70%), and non-desertification (FVC: 71–100%). The accuracy of the vegetation indices was assessed by the overall accuracy (OA), the kappa coefficient (k), and the relative error (RE). Our result showed that the accuracy of SVM-supervised classification was high in assessing each grassland desertification grade. Excess Green Red Blue Difference Index (EGRBDI), Visible Band Modified Soil Adjusted Vegetation Index (V-MSAVI), Green Leaf Index (GLI), Color Index of Vegetation Vegetative (CIVE), Red Green Blue Vegetation Index (RGBVI), and Excess Green (EXG) accurately assessed grassland desertification at severe, high, moderate, and slight grades. In addition, the Red Green Ratio Index (RGRI) and Combined 2 (COM2) were accurate in assessing severe desertification. The assessment of the 19 indices of the non-desertification grade had low accuracy. Moreover, our result showed that the accuracy of SVM-supervised classification was high in assessing each grassland desertification grade. This study emphasizes that the applicability of the vegetation indices varies with the degree of grassland desertification and hopes to provide scientific guidance for a more accurate grassland desertification assessment.
Sleep Quality and Self-Reported Symptoms of Anxiety and Depression Are Associated with Physical Activity in Patients with Severe COPD
Authors: Neale Christopher D. , Christensen Pernille E. , Dall Christian , Ulrik Charlotte Suppli , Godtfredsen Nina , Hansen Henrik
Published: December 2022

Sleep quantity, quality and symptoms of depression or anxiety potentially affect the level of daily physical activity (PAL) and plausibly counteracts benefits from pulmonary rehabilitation programs. Their collective impact on PAL is sparsely investigated, particularly in patients with severely progressed chronic obstructive pulmonary disease (COPD). Aim: To investigate if sleep quantity, quality and symptoms from self-reported hospital anxiety and depression scores (HADS) are associated with PAL. Methods: In this exploratory cross-sectional study data were analysed from 148 participants with COPD; GOLD grade II-IV; GOLD group B to D (52% female, mean 69.7 ± SD of 8.4 years, FEV1% predicted 33.6 ± 10.9, 6MWD 327 ± 122 m, CAT 20 ± 7 points), eligible for conventional outpatient hospital-based pulmonary rehabilitation. Participants had sleep and PAL measured 24 h per day for five consecutive days with an activPAL monitor. Adjusted negative binomial regression was applied to investigate the associations with PAL. Results: Participants walked median (25th, 75th percentile) of 2358 (1325.75; 3822.25) steps per day and 14% walked >5000 steps per day on average. Time in bed (TIB) were a median (25th, 75th percentile) of 8.3 (7.1; 9.7) hours and numbers of nocturnal sleeping bouts (NSB) were 1.5 (0.8; 3), Anxiety (HADS-A) and depression (HADS-D) scores were median (25th, 75th percentile) of 5 (3; 8) points and 3 (2; 6) points, respectively, whereof 29% (HADS-A) and 15% (HADS-D) reported scores ≥8 points indicating significant symptoms. The fully adjusted rate ratio (RR) for steps per day for TIB (hours) [RR 0.97 (95% CI: 0.92; 1.02)], NSB (numbers) [RR 1.02 (95% CI: 0.97; 1.07)] were not significantly associated with number of steps per day, while there was a significantly association with number of steps per day for HADS-A [RR 1.04 (95% CI: 1.01; 1.07)] and HADS-D [RR 0.95 (95% CI: 0.91; 0.99)]. Conclusion: This exploratory cross-sectional study found a statistically significant association between HADS-A and HADS-D with numbers of steps per day in patients with severe COPD.
Towards Carbon Neutrality: Carbon Emission Performance of Science and Technology Finance Policy
Authors: Xu Hong , Liu Baozhen , Lin Kai , Zhang Yunyun , Liu Bei , Xie Mingjie
Published: December 2022

Combining technology with finance is the focus of supporting economic structure adjustment, and environmental benefits are also the proper meaning of the policy. Using the panel data of 274 cities in China from 2006 to 2017, this paper examines the impact of the Science and Technology Finance Policy (STFP) on carbon emission intensity in pilot cities and the transmission mechanisms through the difference-in-differences method and further explores the impact of STFP on the carbon emission intensity in neighboring cities. The results show that (1) STFP has significantly reduced carbon emission intensity in pilot cities and has dynamic effects, which gradually increase over time. There is significant heterogeneity in the carbon emission reduction effect of STFP, which produces stronger policy effects in first and second-tier cities and cities with higher information levels. (2) STFP achieves carbon emission reduction effects through three main pathways: the total factor productivity improvement effect, innovative elements agglomeration effect, and industrial structure optimization effect. (3) The STFP and national e-commerce demonstration policy have an interactive effect, and the two jointly contribute to the reduction in carbon emission intensity. From the perspective of a spatial effect, STFP has a radiation effect; that is, STFP not only reduces local carbon emission intensity but also curbs the carbon emission intensity in neighboring areas.
College Students’ Degree of Support for Online Learning during the COVID-19 Pandemic and Associated Factors: A Cross-Sectional Study
Authors: Huang Xincheng , Deng Yuqian , Ge Pu , Sun Xiaonan , Huang Mengjie , Chen Hejie , Wang Yanyan , Suo Baojun , Song Zhiqiang , Wu Yibo
Published: December 2022

Background: Educational institutions worldwide have experienced the suspension of offline teaching activities in favor of online teaching due to the outbreak of the COVID-19 pandemic. However, few studies have focused on the degree of support for online learning among college students in mainland China. Therefore, the aim of this study was to investigate the degree of support for online learning among Chinese college students during the epidemic and whether depression, loneliness, family communication, and social support were associated factors. Methods: A questionnaire was used to collect cross-sectional data from 9319 college students in mainland China, and a structural equation model was analyzed. Results: The results of the study showed high degrees of support for online learning among Chinese college students during the COVID-19 pandemic, with more than half expressing support. The SEM (Structural Equation Modeling) results showed that depression had a negative and significant effect on college students’ support for online learning (β = −0.07; p < 0.001); family communication had a positive and significant effect on college students’ support for online learning (β = 0.09; p < 0.001); social support had a positive and significant effect on college students’ support for online learning (β = 0.11; p < 0.001). Conclusions: Social support and family communication can alleviate the negative psychological status of college students, and depression plays a mediating role in the effect of social support and family communication on college students’ degree of support for online learning. In addition, a significant chain-mediating effect was found of family communication, loneliness, and depression between social support and college students’ degree of support for online learning. Government and education institutions must focus on college students’ mental health issues and consider family interventions and general support that college students require.
Highly Efficient Treatment of Oily Sludge by a Novel High-Speed Stirring Method at Room Temperature
Authors: Zhu Yimin , Li Keqing , Wang Yin , Zhao Jiao , Tang Xiaojia , Li Tie , Zhang Chenming
Published: December 2022

Oily sludge is one of the main hazardous wastes which seriously endangers the ecological environment and human health. In this paper, in order to effectively treat oily sludge, a novel high-speed stirring (HSS) method was proposed to clean oily sludge, and the main parameters affecting the residual oil rate of oily sludge were studied experimentally. Firstly, the cleaning time and stirring speed were optimized in the one-stage HSS cleaning, and then the optimal cleaning time of two-stage HSS cleaning was determined by the response surface method. The results suggested that the oil can be efficiently separated by high-speed stirring at room temperature, and that the two-stage cleaning with a circular-hole outlet (Rotor-C) followed by a vertical hole-outlet (Rotor-V) presented the best effect. The optimal stirring speed was 6000 r/min, and the optimal cleaning times of the two-stage cleaning were 7 min and 8 min, respectively. After cleaning, the residual oil rate of the treated oily sludge was 1.65%, and the removal rate of the petroleum hydrocarbons was 84.3%.
Exploring an Applied Ecological Model of the Effects of Household, School, and Community Environments on Adolescent Mental Health in Japan
Authors: Mori Nagisa , Arimoto Azusa , Tadaka Etsuko
Published: December 2022

Adolescent mental health is an urgent global public health issue and is affected by household, school, and community environments. However, few studies, and none in Japan, have used applied ecological models to identify environmental factors that affect adolescent mental health. This study aimed to examine an applied ecological model of sequential association between household, school, and community environmental factors and their effects on adolescent mental health in Japan (ECO-AM model). This was a secondary analysis of data from the 2013 Japanese Comprehensive Survey of Living Conditions. Participants were 893 adolescents aged 12–14 years and their household heads living in Japan. Data for 728 adolescents were analyzed after excluding participants with missing values (valid response rate: 81.5%). Screening using the six-item Kessler Psychological Distress Scale demonstrated that 33.8% of adolescents had mood and anxiety disorders. Covariance structure analysis yielded a model with strong goodness-of-fit that described associations between mood and anxiety disorder and vitality, and household, school and community environments. The explanatory variables accounted for 36% of mood and anxiety disorder scores. The study emphasizes the importance of the relationship between different environments and suggests that a better understanding of environmental factors would help support adolescent mental health.
Preventing Postpartum Depression in the Early Postpartum Period Using an App-Based Cognitive Behavioral Therapy Program: A Pilot Randomized Controlled Study
Authors: Qin Xiaoli , Liu Chunfeng , Zhu Wei , Chen Yan , Wang Yudong
Published: December 2022

A large proportion of women experience depression during the postpartum period. Few studies have investigated the use of mobile technology to prevent postpartum depression in women. This study investigated the preliminary effectiveness of the CareMom program, a new app-based cognitive behavioral therapy program, on reducing the depressive symptoms of mothers during the very early postpartum period via a pilot randomized controlled study. The participants were recruited during birth hospitalization (within 3 days after giving birth) and randomized to the waiting-list control and CareMom groups. Over the four-week intervention period, the CareMom group was required to complete 28 daily challenges via CareMom. The depressive (via EPDS) and anxiety (via GAD-7) levels of participants were measured at baseline and every 7 days postbaseline for 4 weeks. A total of 112 eligible participants were randomly allocated to the two groups (CareMom: n = 57; control: n = 55). At week 4, the CareMom group achieved a significantly lower EPDS score than the control group at week 4 (p = 0.037). In addition, the EPDS (p < 0.001) scores of the CareMom group were significantly lower than the baseline values. However, the control group did not show any significant reduction in this measure. No significant reduction of GAD-7 scores was observed for CareMom and control groups at week 4. This study provides preliminary evidence of the effectiveness of CareMom in reducing depressive symptoms in the general postpartum population during the very early postpartum period.
The Effect of Pre-Operative Verbal Confirmation for Interventional Radiology Physicians on Their Use of Personal Dosimeters and Personal Protective Equipment
Authors: Matsuzaki Satoru , Moritake Takashi , Sun Lue , Morota Koichi , Nagamoto Keisuke , Nakagami Koichi , Kuriyama Tomoko , Hitomi Go , Kajiki Shigeyuki , Kunugita Naoki
Published: December 2022

Interventional radiology (IR) physicians must be equipped with personal passive dosimeters and personal protective equipment (PPE); however, they are inconsistently used. Therefore, we aimed to explore practical measures to increase PPE usage and ascertain whether these measures could lead to an actual decrease in exposure doses to IR physicians. Dosimeters and PPE were visually inspected. Then, a pre-operative briefing was conducted as a direct intervention, and the use of dosimeters and PPE was verbally confirmed. Finally, the intervention effect was verified by measuring the use rates and individual exposure doses. Because of the intervention, the use rate markedly improved and was almost 100%. However, both the effective dose rate (effective dose/fluoroscopy time) and the lens equivalent dose rate (lens equivalent dose/fluoroscopy time) showed that the intervention led to a statistically significant increase in exposure (effective dose rate: p = 0.033; lens equivalent dose rate: p = 0.003). In conclusion, the proper use of dosimeters and PPE raised the radiation exposure values for IR physicians immediately after the intervention, which was hypothesized to be due to the inclusion of exposure overlooked to date and the changes in the dosimeter management method from a single- to a double-dosimeter approach.
A Rapid Review of the Factors That Influence Service User Involvement in Interprofessional Education, Practice, and Research
Authors: Sy Michael Palapal , Panotes Arden , Cho Daniella , Pineda Roi Charles , Martin Priya
Published: December 2022

Service user involvement in interprofessional education and collaborative practice remains limited despite the increasing push for this by governments and grant funding bodies. This rapid review investigated service user involvement in interprofessional education, practice, and research to determine factors that enable or hinder such involvement. Following the Cochrane and the World Health Organization’s rapid review guidelines, a targeted search was undertaken in four databases. Subsequent to the screening processes, included papers were critically appraised, and extracted data were synthesized narratively. Sixteen studies met inclusion criteria. Most studies were related to interprofessional collaborative practice, as opposed to education and research. Service user involvement was more in the form of consultation and collaboration, as opposed to consumer-led partnerships. Enablers and barriers to service user involvement in IPECP were identified. Enablers included structure, the valuing of different perspectives, and relationships. Barriers included time and resources, undesirable characteristics, and relationships. This rapid review has added evidence to a swiftly expanding field, providing timely guidance. Healthcare workers can benefit from targeted training. Policy makers, healthcare organizations, and governments can investigate strategies to mitigate the time and resource challenges that impede service user involvement in IPECP.
Social Networks, Health Information Sharing, and Pandemic Perceptions among Young Adults in Hawai’i during the COVID-19 Pandemic
Authors: Phillips Michael M. , Weldon Rosana Hernandez , Maniar Anam , Patil Uday , Kostareva Uliana , Agner Joy , Finn Julia , Sentell Tetine
Published: December 2022

Limited information exists about social network variation and health information sharing during COVID-19, especially for Native Hawaiians (NH), Other Pacific Islanders (OPI), and Filipinos, who experienced COVID-19 inequities. Hawai’i residents aged 18–35 completed an online survey regarding social media sources of COVID-19 information and social network health information measured by how many people participants: (1) talked to and (2) listened to about health. Regression models were fit with age, gender, race/ethnicity, chronic disease status, pandemic perceptions, and health literacy as predictors of information sources (logistic) and social network size (Poisson). Respondents were 68% female; 41% NH, OPI, or Filipino; and 73% conducted a recent COVID-19 digital search for themselves or others. Respondents listened to others or discussed their own health with ~2–3 people. Respondents who talked with more people about their health were more likely to have larger networks for listening to others. In regression models, those who perceived greater risk of acquiring COVID-19 discussed their health with more people; in discussing others’ health, women and those with chronic diseases listened to a greater number. Understanding young adults’ social networks and information sources is important for health literacy and designing effective health communications, especially to reach populations experiencing health inequities.
Symptoms of Depression, Anxiety, and Posttraumatic Stress among Patients with Cardiac Pacemakers
Authors: Bürker Britta S. , Hardersen Randolf I. , Lappegård Knut Tore
Published: December 2022

Despite being a prerequisite for tailoring specific therapeutic interventions, knowledge of pattern and prevalence of clinically significant psychiatric symptomatology among patients with cardiac pacemakers (PMs), especially of symptoms of posttraumatic stress, is limited. We studied symptoms of depression, anxiety, and posttraumatic stress among PM patients (PM due to syncope or presyncope) compared to participants of (i) a cardiac, (ii) a chronic disease, and (iii) a healthy control group. Symptoms of depression, anxiety and posttraumatic stress were measured by validated self-report scales at least 6 months after implantation of the PM (PM group; n = 38), percutaneous coronary intervention (PCI; PCI control group; n = 23), and first dialysis (Dialysis control group; n = 17). Blood donors constituted the Healthy control group (n = 42). Both PM, PCI, and dialysis patients reported depressive symptoms above clinical cut-off more frequently than the healthy controls (16.2, 26.1, 41.2, and 0%, respectively; p < 0.001). Self-report of symptoms of anxiety and posttraumatic stress did not differ significantly across study groups. However, a non-negligible proportion of PM patients reported on symptoms of posttraumatic stress of anticipated clinical relevance. Identification and treatment of depression deserves attention in clinical routine in all three patient populations. Further study of posttraumatic stress in PM patients seems advisable.
Deep Dive into the Long Haul: Analysis of Symptom Clusters and Risk Factors for Post-Acute Sequelae of COVID-19 to Inform Clinical Care
Authors: Goldhaber Nicole H. , Kohn Jordan N. , Ogan William Scott , Sitapati Amy , Longhurst Christopher A. , Wang Angela , Lee Susan , Hong Suzi , Horton Lucy E.
Published: December 2022

Long COVID is a chronic condition characterized by symptoms such as fatigue, dyspnea, and cognitive impairment that persist or relapse months after an acute infection with the SARS-CoV-2 virus. Many distinct symptoms have been attributed to Long COVID; however, little is known about the potential clustering of these symptoms and risk factors that may predispose patients to certain clusters. In this study, an electronic survey was sent to patients in the UC San Diego Health (UCSDH) system who tested positive for COVID-19, querying if patients were experiencing symptoms consistent with Long COVID. Based on survey results, along with patient demographics reported in the electronic health record (EHR), linear and logistic regression models were used to examine putative risk factors, and exploratory factor analysis was performed to determine symptom clusters. Among 999 survey respondents, increased odds of Long COVID (n = 421; 42%) and greater Long COVID symptom burden were associated with female sex (OR = 1.73, 99% CI: 1.16–2.58; β = 0.48, 0.22–0.75), COVID-19 hospitalization (OR = 4.51, 2.50–8.43; β = 0.48, 0.17–0.78), and poorer pre-COVID self-rated health (OR = 0.75, 0.57–0.97; β = −0.19, −0.32–−0.07). Over one-fifth of Long COVID patients screened positive for depression and/or anxiety, the latter of which was associated with younger age (OR = 0.96, 0.94–0.99). Factor analysis of 16 self-reported symptoms suggested five symptom clusters—gastrointestinal (GI), musculoskeletal (MSK), neurocognitive (NC), airway (AW), and cardiopulmonary (CP), with older age (β = 0.21, 0.11–0.30) and mixed race (β = 0.27, 0.04–0.51) being associated with greater MSK symptom burden. Greater NC symptom burden was associated with increased odds of depression (OR = 5.86, 2.71–13.8) and anxiety (OR = 2.83, 1.36–6.14). These results can inform clinicians in identifying patients at increased risk for Long COVID-related medical issues, particularly neurocognitive symptoms and symptom clusters, as well as informing health systems to manage operational expectations on a population-health level.
Disinformation: A Bibliometric Review
Authors: Wang Shixiong , Su Fangfang , Ye Lu , Jing Yuan
Published: December 2022

Objectives: This paper aimed to provide a systematic review of relevant articles from the perspectives of literature distribution, research hotspots, and existing results to obtain the frontier directions in the field of disinformation. Methods: We analyzed disinformation publications published between 2002 and 2021 using bibliometric methods based on the Web of Science. There were 5666 papers analyzed using Derwent Data Analyzer (DDA). Results: The result shows that the USA was the most influential country in this area, while Ecker and Lewandowsky from the University of Western Australia published the largest volumes of papers. Keywords such as “social media”, “COVID-19”, and “vaccination” have gained immense popularity recently. Conclusions: We summarized four themes that are of the biggest concern to scholars: group heterogeneity of misinformation in memory, disinformation mechanism in social media, public health related to COVID-19, and application of big data technology in the infodemic. The future agenda of disinformation is summarized from three aspects: the mechanism of disinformation, social media users, and the application of algorithms. This work can be a meaningful resource for researchers’ study in the area of disinformation.
Tumor Suppressor miRNA-503 Inhibits Cell Invasion in Head and Neck Cancer through the Wnt Signaling Pathway via the WNT3A/MMP Molecular Axis
Authors: Tang Shang-Ju , Fan Kang-Hsing , You Guo-Rung , Huang Shiang-Fu , Kang Chung-Jan , Huang Yi-Fang , Huang Yu-Chen , Chang Joseph Tung-Chieh , Cheng Ann-Joy
Published: December 2022

Head and neck cancer (HNC) is the fifth most common cancer worldwide, and its incidence and death rates have been consistently high throughout the past decades. MicroRNAs (miRNAs) have recently gained significant attention because of their role in the regulation of a variety of biological processes via post-transcriptional silencing mechanisms. Previously, we determined a specific profile of miRNAs associated with HNC using a miRNA microarray analysis. Of the 23 miRNAs with highly altered expression in HNC cells, miR-503 was the most significantly downregulated miRNA. In this study, we confirmed that miR-503 acts as a tumor suppressor, as our results showed decreased levels of miR-503 in cancer cells and patients with HNC. We further characterized the role of miR-503 in the malignant functions of HNC. Although there was a minimal effect on cell growth, miR-503 was found to inhibit cellular invasion significantly. Algorithm-based studies identified multiple potential target genes and pathways associated with oncogenic mechanisms. The candidate target gene, WNT3A, was confirmed to be downregulated by miR-503 at both the mRNA and protein levels and validated by a reporter assay. Furthermore, miR-503 modulated multiple invasion-associated genes, including matrix metalloproteinases (MMPs), through the Wnt downstream signaling pathway. Overall, this study demonstrates that miR-503 suppresses HNC malignancy by inhibiting cell invasion through the Wnt signaling pathway via the WNT3A/MMP molecular axis. The modulation of miR-503 may be a novel therapeutic approach to intervene in cancer invasion.
CTLA-4 Expression Is a Promising Biomarker of Idiopathic Pulmonary Arterial Hypertension and Allows Differentiation of the Type of Pulmonary Hypertension
Authors: Tomaszewski Michał , Małkowska Paulina , Sierawska Olga , Hrynkiewicz Rafał , Mroczek Ewa , Darocha Szymon , Hymos Anna , Błaszczak Piotr , Grywalska Ewelina , Niedźwiedzka-Rystwej Paulina
Published: December 2022

Pulmonary arterial hypertension (PAH) is an increasingly frequently diagnosed disease, the molecular mechanisms of which have not been thoroughly investigated. The aim of our study was to investigate subpopulations of lymphocytes to better understand their role in the molecular pathomechanisms of various types of PAH and to find a suitable biomarker that could be useful in the differential diagnosis of PAH. Using flow cytometry, we measured the frequencies of lymphocyte subpopulations CD4+CTLA-4+, CD8+ CTLA-4+ and CD19+ CTLA-4+ in patients with different types of PAH, namely pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH), pulmonary arterial hypertension associated with connective tissue disorders (CTD-PAH), chronic thromboembolic pulmonary hypertension (CTEPH) and idiopathic pulmonary arterial hypertension (iPAH), and in an age- and sex-matched control group in relation to selected clinical parameters. Patients in the iPAH group had the significantly highest percentage of CD4+CTLA-4+ T lymphocytes among all PAH groups, as compared to those in the control group (p < 0.001), patients with CTEPH (p < 0.001), CTD-PAH (p < 0.001) and CHD-PAH (p < 0.01). In iPAH patients, the percentages of CD4+CTLA-4+ T cells correlated strongly positively with the severity of heart failure New York Heart Association (NYHA) Functional Classification (r = 0.7077, p < 0.001). Moreover, the percentage of B CD19+CTLA-4+ cells strongly positively correlated with the concentration of NT-proBNP (r = 0.8498, p < 0.001). We have shown that statistically significantly higher percentages of CD4+CTLA-4+ (p ≤ 0.01) and CD8+ CTLA-4+ (p ≤ 0.001) T cells, measured at the time of iPAH diagnosis, were found in patients who died within 5 years of the diagnosis, which allows us to consider both of the above lymphocyte subpopulations as a negative prognostic/predictive factor in iPAH. CTLA-4 may be a promising biomarker of noninvasive detection of iPAH, but its role in planning the treatment strategy of PAH remains unclear. Further studies on T and B lymphocyte subsets are needed in different types of PAH to ascertain the relationships that exist between them and the disease.
A Comprehensive Survey of Prospective Structure-Based Virtual Screening for Early Drug Discovery in the Past Fifteen Years
Authors: Zhu Hui , Zhang Yulin , Li Wei , Huang Niu
Published: December 2022

Structure-based virtual screening (SBVS), also known as molecular docking, has been increasingly applied to discover small-molecule ligands based on the protein structures in the early stage of drug discovery. In this review, we comprehensively surveyed the prospective applications of molecular docking judged by solid experimental validations in the literature over the past fifteen years. Herein, we systematically analyzed the novelty of the targets and the docking hits, practical protocols of docking screening, and the following experimental validations. Among the 419 case studies we reviewed, most virtual screenings were carried out on widely studied targets, and only 22% were on less-explored new targets. Regarding docking software, GLIDE is the most popular one used in molecular docking, while the DOCK 3 series showed a strong capacity for large-scale virtual screening. Besides, the majority of identified hits are promising in structural novelty and one-quarter of the hits showed better potency than 1 μM, indicating that the primary advantage of SBVS is to discover new chemotypes rather than highly potent compounds. Furthermore, in most studies, only in vitro bioassays were carried out to validate the docking hits, which might limit the further characterization and development of the identified active compounds. Finally, several successful stories of SBVS with extensive experimental validations have been highlighted, which provide unique insights into future SBVS drug discovery campaigns.