bluuebunny/crossref_metadata_2025 huggingface dataset:
An Investigation of Data Requirements for the Detection of Depression
from Social Media Posts
Authors: Dalal Sumit , Jain Sarika , Dave Mayank
Published: August 2022

Background:

Only a fraction of the produced social media data is usable in mental health assessment. So the problem of sufficient training data for deep learning approaches arises. Data sufficiency can be presented in terms of number of users or number of posts per user.

Objective:

We examine the data need of machine learning and deep learning models for a practical system and let researcher chose best fitting models depending on the dataset type available with them. We perform distinct experiments to find the effect of these issues on depression classification by various approaches.

Methods:

We explored various machine learning and deep learning techniques on various data set versions, taken from Twitter and Reddit, with varying numbers of users and posts per user. Diagnosed and control users are taken in different ratios to assess the impact of an imbalanced dataset.

Results:

The results reveal that SVM achieved 68% accuracy in depression classification for 70 users each from diagnosed and control group. It decreases for 150 users from each group, but then regains performance for 350 and 550 users from each group.

Conclusion:

Conclusion: We found, mainly, classification accuracy increases with the number of users, number of posts per user and imbalance in the number of diagnosed versus control users. We also found that posts from Reddit have better accuracy compared to tweets.
De verborgen kost van verspreide bebouwing en riolering
Authors: Van Speybroeck Kato
Published: August 2022

Wie Vlaanderen doorkruist ziet overal huizen en ellenlange verkavelingslinten doorheen het landschap kronkelen. Dat deze sterk versnipperde nederzettingsstructuur niet fraai oogt is alom bekend, maar de maatschappelijke kosten die hieraan vastzitten veel minder. In mijn thesis gebruikte ik de monetaire kosten van de Vlaamse rioleringen om dit te duiden.
Simetría y balance muscular de flexo-extensores de rodilla a 60°/segundo en estudiantes militares
Authors: Cleves Neuta Felipe , Cruz Martínez María Camila , Contreras Zúñiga Jenner Alberto , Melo Buitrago Paula Janyn , Arango Martínez Sebastián Felipe
Published: August 2022

El objetivo de este artículo es analizar el nivel de simetría y balance muscular a 60°/ segundo de flexoextensores de rodilla en estudiantes militares. Como metodología se utilizó el enfoque cuantitativo, alcance descriptivo y corte transversal; población de 75 estudiantes hombres con edad ꭕ: 19,76 ± 1,35; evaluados mediante el test de fuerza isocinética. El balance muscular cuádriceps/isquiotibiales presentó ratios equivalentes al 60%, siendo este un buen indicador de niveles de fuerza según los estándares de normalidad, factor que indica un bajo riesgo de lesión de rodilla.
Speech-Language Pathology Management for Adults with COVID-19 in the Acute Hospital Setting: What Do We Know?
Authors:   Speech-Language Pathology, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, NY 10595, United States, Riquelme Luis F. ,   Maimonides Health, 4802 Tenth Avenue, Brooklyn, NY, 11219, United States, Diab Sara ,   School of Rehabilitation Science, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada, Horyacheva Angela ,   School of Rehabilitation Science, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada, Huribal Isabel ,   Speech-Language Pathology, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, NY 10595, United States, Shellerud Andreea ,   Speech-Language Pathology, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, NY 10595, United States, Abrams Sophia Werden ,   School of Rehabilitation Science, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada, Namasivayam-MacDonald Ashwini M. ,   School of Rehabilitation Science, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada† These authors contributed equally to this work.
Published: August 2022

The purpose of this study was to collate and summarize the content covered in published literature describing speech-language pathology management of adult patients with COVID-19 in the acute hospital setting as of February 2022. This review serves as an updated review of the initial recommendations to guide speech-language pathology management for adults with COVID-19 in the acute hospital setting previously provided by Namasivayam-MacDonald and Riquelme in July of 2020. This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping Review Extension protocol. We searched for relevant peer-reviewed articles in the following electronic databases: MEDLINE, EMBASE, and CINAHL. The article review process was conducted using Covidence. Our searches yielded a combined total of 3019 unique citations, of which 54 were accepted for full-text review. Thirty-seven of the 54 studies were review articles, recommendations, or opinion pieces. This translates to mostly low levels of evidence (i.e., Levels VI and VII) and a grade of ‘D’ when applying the American Society of Plastic Surgeons grade recommendation scale for evidence-based clinical practice guidelines, meaning there is little or no systematic empirical evidence available. The remaining 17 provided empirical data, which translates to higher levels of evidence and a grade of ‘B’. The empirical data shared in this scoping review provide support for the ongoing role of the SLP in the acute care setting and the impact COVID-19 and its variants have on the underlying systems for communication and swallowing. This document serves as further proof of the need for ongoing research into the clinical presentations of patients with speech-language, cognitive and/or swallowing deficits resulting from COVID-19, as well as into systems of care that will provide the best outcomes in their rehabilitation.
Wearable health and activity trackers utilization and physical activity among informal caregivers in the United States (Preprint)
Authors: Mahmood Asos , Kim Hyunmin , Kedia Satish , Dillon Patrick
Published: August 2022

BACKGROUND

With an increase in aging population and chronic medical conditions in the United States (US), the role of informal caregivers has become paramount as they engage in the care of their loved ones. Mounting evidence suggests that such responsibilities place significant burdens on informal caregivers and can negatively impact their own health. New wearable health and activity trackers (wearables) are increasingly being used to facilitate and monitor healthy behaviors and to improve health outcomes. Although prior studies have examined the efficacy of wearables in improving health and wellbeing in the general population, little is known about their benefits among informal caregivers.

OBJECTIVE

This study examines the association between use of wearables and levels of physical activity among informal caregivers in the US.

METHODS

We utilized data from the National Cancer Institute’s Health Information National Trends Survey (HINTS 5-Cycle 3 [2019] & Cycle 4 [2020]) for a nationally-representative sample of 1,273 community-dwelling informal caregivers (aged ≥18 years; females = 60%; some college or more in education = 75.7%; caring for patients with ≥one chronic medical condition = 67.3%) in the US. Using jackknife replicate weights, a multivariable logistic regression was fit to assess an independent association between the use of wearables and a binary outcome: meeting or not meeting the current World Health Organization’s recommendation on physical activity for adults (≥150 minutes of at least moderate-intensity physical activity per week).

RESULTS

Over one-third (37.8%; n=466) of the informal caregivers met the recommendations for adult physical activity. However, those who reported using wearables (n=390) had slightly higher odds of meeting physical activity recommendations (Adjusted OR= 1.10; 95% Confidence Interval: 1.04, 1.77; P=.042) compared to those who did not use wearables.

CONCLUSIONS

The results demonstrate a positive association between the use of wearables and levels of physical activity among informal caregivers in the US. Therefore, efforts to incorporate wearable technology into the development of health-promoting programs or interventions for informal caregivers could potentially improve their health and wellbeing. Future longitudinal studies are required to further support the current findings.
Factors Associated with Self-Reported Use of Web and Mobile Health Applications: Results from a Cross-Sectional Survey of US Military Veterans (Preprint)
Authors: Hogan Timothy P. , Etingen Bella , Lipschitz Jessica M. , Shimada Stephanie L. , McMahon Nicholas , Bolivar Derek , Bixler Felicia R. , Irvin Dawn , Wacks Rachel , Cutrona Sarah , Frisbee Kathleen L. , Smith Bridget M.
Published: August 2022

BACKGROUND

Despite their prevalence and reported patient interest in use, uptake of health-related applications (apps) is limited. The Veterans Health Administration (VHA) has developed a variety of mobile and web-based apps to support Veterans; however, uptake remains low nationally.

OBJECTIVE

Our objective was to examine factors associated with self-reported VHA health-related app use among US military Veterans.

METHODS

We collected data via a cross-sectional national survey of Veterans and supplemented that data with VHA administrative data. We assessed factors associated with app use using bivariate analyses and multiple logistic regression models.

RESULTS

We had complete data on 1,259 Veterans. Among them, 47.3% reported having used a VHA health-related app. Respondents reported learning about available VHA health-related apps by reading about them on VHA’s patient portal (37.2%), being told about them by their VHA healthcare team (25.1%), and/or reading about them on VHA’s website (11.0%). Among other significant factors, Veterans who had VHA healthcare team members encourage them to use apps (OR=2.7, 95% CI=2.1-3.4) were more likely to self-report use.

CONCLUSIONS

We found a strong association between healthcare team member encouragement and self-reported app use. Veterans who reported receiving encouragement from their VHA care team members had nearly three times higher odds of using VHA apps than Veterans who did not report receiving such encouragement. Our results add to growing evidence suggesting that endorsement of apps by a healthcare system or healthcare providers can positively impact patient uptake and use, which has implications for future efforts to bolster implementation of these technologies.
Kinetika Perubahan Ketengikan (Rancidity) Kacang Goreng selama Proses Penyimpanan
Authors: Maharani Dewi Maya , Bintoro Nursigit , Rahardjo Budi
Published: August 2022

Rancidity is a damage or change in odor and flavor in the fat or fatty food. As one of the fatty food products, peanut is susceptible to rancidity during storage.The duration of heating oil resulting in changes of peroxide value of oil as a medium frying pan provides quality changes in fried ingredients. Besides that, availability of oxygen in the package would also affect on the rate of the rancidity process. The purpose of this study was to develop a mathematical model of rancidity changes of fried peanuts during storage expressed by increasing the numerical value of its peroxide. The variation of heating oil used were 0, 1, 2 and 3 hours. While the variation of ratio of peanut volume with the packaging material used were 1:6, 5:13 and 10:17. The results showed that the longer the heating oil, the greater the number peroxide as well as the number of results of frying beans. The smaller the volume ratio of peanuts to the packaging used, the greater the rate constant changes in peroxide value fried peanuts or the faster the rancidity of the peanut. The equation of constant rate of change of peroxide value fried peanuts (rancidity) during storage could be expressed by P(t) P0.e (0.17)RS-0.10 Xt.ABSTRAKKetengikan (rancidity) merupakan kerusakan atau perubahan bau dan flavor dalam lemak atau bahan pangan berlemak. Sebagai salah satu produk  pangan  berlemak  kacang  rentan  terhadap  ketengikan  selama  penyimpanan.  Lama pemanasan minyak dapat mengakibatkan perubahan nilai angka peroksidanya, sehingga akan mempengaruhi kualitas pada bahan yang digoreng. Disamping itu ketersediaan oksigen dalam kemasan ditengarai juga akan mempengaruhi terjadinya proses ketengikan. Tujuan penelitian ini untuk mengembangkan model matematis perubahan ketengikan kacang goreng selama penyimpanan yang dinyatakan dengan peningkatan nilai angka peroksidanya. Variasi lama pemanasan minyak yang digunakan adalah 0, 1, 2 dan 3 jam. Sedangkan variasi rasio volume kacang dengan kemasan yang digunakan adalah 1:6, 5:13 dan 10:17. Hasil penelitian menunjukkan bahwa semakin lama pemanasan minyak, maka semakin besar angka peroksidanya demikian juga angka peroksida dari kacang hasil penggorengannya. Semakin kecil rasio volume kacang dengan kemasan yang digunakan, maka semakin besar konstanta laju perubahan angka peroksida kacang goreng atau kacang semakin cepat tengik. Persamaan konstanta laju perubahan angka peroksida kacang goreng (ketengikan) selama penyimpanan dapat dinyatakan dengan P(t) P0.e (0.17)RS-0.10 Xt.
Aktivitas Lipase Indigenous selama Perkecambahan Biji Kakao (Theobroma cacao L.)
Authors: Mayun Permana I Dewa Gde , Indrati Retno , Hastuti Pudji , Suparmo Suparmo
Published: August 2022

The aim of the research was to find the highest activity of cocoa bean lipase during germination. The lipase activity was determined every day for 10 days germination period. The result indicated that the highest hydrolysis activity of the extracted lipase was found at the 3th day of germination =  0,138 U/gram bean and that of esterification was at 4th day =  0,252 U/gram bean. During germination, bean weight and fat content decreased while water content increased. Free fatty acid and soluble protein were in fluctuation during germination.ABSTRAKPenelitian ini bertujuan untuk mendapatkan aktivitas tertinggi lipase biji kakao selama perkecambahan. Aktivitas lipase dianalisis setiap hari selama 10 hari perkecambahan. Lipase terekstrak menunjukkan aktivitas hidrolisis tertinggi dari perkecambahan 3 hari = 0,138 U/gram biji dan aktivitas esterifikasi pada perkecambahan 4 hari = 0,252 U/ gram biji. Aktivitas esterifikasi lebih tinggi dibandingkan hidrolisis selama perkecambahan. Berat biji, kadar lemak mengalami penurunan selama perkecambahan, sedangkan kadar air mengalami peningkatan. Asam lemak bebas dan protein terlarut berfluktuasi selama perkecambahan.
Sintesis Ester Metil Rantai Medium dari Minyak Kelapa dengan Cara Metanolisis Kimiawi
Authors: Karouw Steivie , Suparmo Suparmo , Hastuti Pudji , Utami Tyas
Published: August 2022

Synthesis of fatty acid methyl ester from coconut oil has conducted by chemical methanolysis. The objectives of the research were to evaluate the effect of temperature reaction on yield and profile of fatty acid methyl ester and the fractionation process on medium chain fatty acids methyl ester content. Coconut oil was extracted from 11-12 months of Mapanget Tall coconut variety fruit. The oil was then analyzed to evaluate the physycochemical properties and fatty acids profile. Methanolysis reaction was conducted using potassium metoxide as a catalyst at 50, 55 and 60oC for 2 hours. The methanolysis products were then measured for the yield and were determined for fatty acids profile. Furthermore, the fatty acid methyl ester was franctionated by melting from solid to liquid form. The results showed that the coconut oil had a good quality and medium chain fatty acid content was 61.93%, whereas lauric acid was the major component about 48.24%. The yield of fatty acid methyl ester was 85.41-86.69% and medium chain methyl ester content were 60.81%, 61.84% and 59.85% at reaction temperature of 50oC, 55oC and 60oC, respectively. Ester methyl lauric was a major component of 48.84 – 49.04%. Dry fractionation process only increased 6.68% of fatty acids methyl laurate content.ABSTRAKPada penelitian ini dilakukan sintesis ester metil asam lemak minyak kelapa dengan cara metanolisis kimiawi. Tujuan dari penelitian ini adalah mengetahui pengaruh suhu metanolisis terhadap yield dan profil ester metil asam lemaknya serta perlakuan fraksinasi terhadap kandungan ester metil asam lemak rantai medium. Minyak kelapa diekstraksi dari daging buah kelapa varietas Dalam Mapanget umur buah 11-12 bulan. Minyak kelapa yang diperoleh dianalisis sifat kimianya dan profil asam lemaknya. Reaksi metanolisis dilakukan secara kimiawi menggunakan katalisator kalium metoksida pada suhu 50, 55 dan 60oC selama 2 jam. Hasil metanolisis diukur yield dan proporsi asam lemaknya. Selanjutnya ester metil yang dihasilkan difraksinasi dengan metode beku ke cair. Hasil analisis diperoleh bahwa minyak kelapa mempunyai kualitas yang baik dan asam lemak rantai medium sebesar 61,93% yang didominasi oleh asam laurat sekitar 48,24%. Yield ester metil yang dihasilkan berkisar 85,41-86,69% dengan total kandungan ester metil rantai medium yang dihasilkan berturut-turut 60,81%, 61,84% dan 59,85% masing-masing pada suhu 50oC, 55oC dan 60oC. Proporsi tertinggi adalah ester metil laurat yaitu sebesar 48,84 - 49,04%. Proses fraksinasi kering dengan metode beku ke cair hanya dapat meningkatkan proporsi ester metil laurat sebesar 6,68%.
Validasi Metode Analisis Multiresidu Pestisida Organoklor dalam Salak Menggunakan Kromatografi Gas-Detektor Penangkap Elektron
Authors: Raharjo Tri Joko , Sutriyanto Bambang , Anugrahwati Mai , Aprilita Nurul Hidayat
Published: August 2022

Validation of methods is a key step in the accreditation process of the method. Validation of organoklor pesticide residues method in snakefruit based on the method recommended by FAO-WHO, conducted in LPPT-UGM reported in this study. Snake fruit was homogenized, extracted using toluene/2-propanol (2:1), cleaned up using activated carbon and Celite 545, followed by analysis using gas chromatography-electron capture detector. Validation covered specificity and selectivity, limits of detection and quantification, linear range, precision and accuracy. Validation results showed good specificity and selectivity shown by the inter-peak chromatogram resolution greater than 1.5. Limits of detection and quantification for heptaklor, endosulfan, dieldrin and p, p-DDT were 0.002 and 0.006, 0.5 and 1.7; 0.0006 and 0.002, as well as 0.014 and 0.047 ppm respectively. The linear range for heptaklor, endosulfan, dieldrin, and p,p-DDT were 0.0017 to 2 ppm, 0.165 to 2 ppm, 0.023 to 2 ppm and 0.229 to 2 ppm, respectively. Precision methods meet the acceptance of Horwitz RSD value less than 12.78% at a concentration of 0.3 ppm. Accuracy is indicated by recovery, for each pesticide in the range of 80-110% acceptance at a concentration of 0.1 ppm. Analysis of organochlorine pesticides in three commercial snakefruit samples showed no pesticide residues at concentrations higher than the detection limit.ASBTRAKValidasi metode merupakan tahap kunci dalam proses akreditasi suatu metode. Validasi metode uji residu pestisida organoklor dalam salak berdasarkan metode yang direkomendasikan FAO-WHO, di LPPT-UGM dilaporkan pada penelitian ini. Buah salak dihomogenisasi, diekstraksi menggunakan toluen/2-propanol (2:1), clean up menggunakan karbon aktif dan Celite 545, dilanjutkan analisis menggunakan kromatografi gas-detektor penangkap elektron. Validasi mencakup spesifisitas dan selektivitas, batas deteksi dan kuantifikasi, range linier, presisi serta akurasi. Hasil validasi menunjukkan spesifisitas dan selektivitas yang baik ditunjukkan dengan resolusi antar puncak kromatogram lebih besar dari 1,5. Batas deteksi dan batas kuantifikasi untuk heptaklor, endosulfan, dieldrin dan p,p-DDT secara berturut-turut adalah 0,002 dan 0,006; 0,5 dan 1,7; 0,0006 dan 0,002; serta 0,014 dan 0,047 ppm. Range linier untuk heptaklor adalah 0,0017-2 ppm, endosulfan 0,165-2 ppm, dieldrin 0,023-2 ppm dan p,p-DDT 0,229-2 ppm. Presisi metode memenuhi batas keberterimaan Horwitz dengan nilai RSD lebih kecil dari 12,78% pada konsentrasi 0,3 ppm. Akurasi ditunjukkan dengan recovery, untuk tiap pestisida masuk dalam rentang keberterimaan 80-110% pada konsentrasi 0,1 ppm. Analisis pestisida organoklorin pada 3 sampel salak komersial menunjukkan tidak adanya residu pestisida dengan konsentrasi lebih tinggi dari batas deteksi.
Potensi Isolat Khamir H10 sebagai Agensia Biologis untuk Pengendalian Mucor piriformis pada Buah Apel
Authors: Widyastuti Sri
Published: August 2022

The potency of the yeast cell isolate H10 in suppressing post-harvest rot, Mucor piriformis, was studied in the wounds of apple fruit. Spore inoculum at diffierent concentrations were inoculated into the artificially-made wounds of fresh picking apple fruit. There were five replicates of single fruit with 4 wounds each. Fruits were incubated at 20 °C for 4 days. Increasing concentration of the pathogen spores applied in the wounds, produced higher percentage of rot and diameter of lesion. At the concentration of 107 and 108 cfu ml-1, the yeast cells were able to suppress the percentage of infection and diameter of lesion caused by the pathogen up to 65 %. The inhibition activity of the yeast cells was most highest when the yeast applied coincidentally or 2 hours before inoculation of the pathogen inoculum. These evidences indicate that the yeast is potential to be developed as a protective bio-control agent to suppress the development of post-harvest diseases of apple caused by M. piriformis.ABSTRAKPotensi sel khamir isolat H10 untuk menghambat perkembangan jamur patogen pasca panen Mucor piriformis dipela- jari pada luka buatan pada buah apel. Larutan spora pada berbagai konsentrasi diinokulasikan ke dalam luka buatan pada buah apel segar. Setiap perlakuan menggunakan lima buah apel yang masing-masing mempunyai 4 buah luka. Buah kemudian disimpan untuk dihitung persentase infeksi dan diameter luka yang terjadi selama 4 hari penyimpanan pada suhu 20 °C. Meningkatnya konsentrasi spora patogen yang diinokulasikan pada luka, meningkat pula persentase infeksi dan diameter luka. Sel khamir terbukti mampu menggandakan diri pada permukaan jaringan luka. Pada kon- sentrasi 107  dan 108  cfu ml-1, sel khamir dapat secara nyata menghambat perkembangan jamur patogen sampai 65%. Penghambatan tersebut lebih efektif pada sel khamir yang diaplikasikan bersamaan dengan atau 2 jam sebelum inokulasi inokulum spora pathogen. Efektifitas penghambatan pada buah segar lebih tinggi dibanding pada buah yang telah disimpan beberapa lama. Kenyataan tersebut mengisyaratkan bahwa isolat khamir H10 mempunyai potensi dapat dikembangkan menjadi agensia biologis yang bersifat protektif untuk pengendalian penyakit pasca panen buah apel yang disebabkan oleh M. piriformis.
Study of Household Biodigesters
Authors: Purnomo Chandra Wahyu , Pertiwiningrum Ambar , Kurniawan M. Prasetya
Published: August 2022

Tunnel or tubular type of bio-digester has been widely developed in many countries for producing a renewable clean fuel gas named biogas. This digester type only requires minimum maintenance and simple construction for ensuring its lower cost compared to others with similar capacity. Mostly, polyethylene (PE) plastic bag is used for construction materials of the tubular digesters. In this research, the tubular type has been constructed using large diameter PVC (Poly Vinyl Chloride) pipe for increasing the durability and safety. The performance of PVC digesters have been tested by measuring biogas production rate and CH concentration in the gas. COD (Chemical Oxygen Demand) and BOD (Biological Oxygen Demand) drop between inlet and outlet sludge have been measured for examining the digester ef- ficiency. Then, the performance was compared with PE plastic digesters data from several literatures which still needs some improvements for enhancing its capability and performance.
A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract
Authors: Salnus Subakir , Wahab Wahid , Arfah Rugaiyah , Zenta Firdaus , Natsir Hasnah , Muri Muriyati , Fatimah Fatimah , Rajab Arini , Armah Zulfian , Irfandi Rizal
Published: August 2022

Nanotechnology explores nanoscale materials that can be used in a wide range of industries such as biotechnology, cosmetics, drug delivery, nanomedicine, and biosensors. Nanoparticles in diverse shapes and sizes can be prepared through physical, chemical, and biological methods. The employment of reducing agents, which will change their form, size range, level of stability, and interaction, is a crucial part thus employing a biological approach is necessary. Chemically generated metal oxide nanoparticles raise considerable issues owing to the usage of hazardous and poisonous chemicals, as well as the potential for conservational impairment. In contrast, the production of silver nanoparticles using the principal method of green synthesis has found a special place in research that is considered more environmentally approachable requiring the use to produce non-toxic nanomaterials. Plants and polymer materials have received a lot of interest in the preparation of nanoparticles since they are renewable and affordable. In this review, we present a comprehensive overview of more ecologically friendly synthesis techniques that use plant extracts to make silver nanoparticles and their application as antibacterial agents, as well as toxicity features based on the shape, size range, and phytochemical mechanism of plants.
Sesquiterpenoids from the Stem Bark of Lansium domesticum Corr. Cv. Kokossan and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines
Authors: Sinaga Siska Elisahbet , Mayanti Tri , Naini Al Arofatus , Harneti Desi , Nurlelasari Nurlelasari , Maharani Rani , Farabi Kindi , Supratman Unang , Fajriah Sofa , Azmi Mohamad Nurul
Published: August 2022

The n-hexane fraction from the stem bark of Lansium domesticum Corr. Cv. Kokosan afforded 3 sesquiterpenoids, namely eudesm-4(15),7-dien-1β-ol (1), eudesm-4(15)-ene-1β,6α-diol (2), and octahydro-4-hydroxy-3a-methyl-7-methylene-a-(1-methylethyl)-1H-indene-1-methanol (3). These three compounds were discovered in the Lansium genus for the first time. Their chemical structures were determined based on data generated from various spectroscopic methods, including one- and two-dimensional NMR, as well as mass spectroscopy. Sesquiterpenoid compounds (1-3) have also been evaluated on MCF-7 breast cancer cell lines and the compound 1 showed the strongest activity with an IC50 value of 17.97 µg/mL while compounds 2 and 3 showed moderate and weak activity with IC50 values of 121.65 and 201.57 µg/mL, respectively. The implication of the findings of these compounds is as an illustration that one of these sesquiterpenoids has potential as an anticancer with the presence of double bond which played important role in the cytotoxic activity that can be studied for new drug discovery.
Heavy Metals Concentration in Muscle Tissue of Threatened Sharks (Rhizoprionodon acutus, Sphyrna lewini, and Squallus hemipinnis) from Binuangeun, Lebak Banten, Indonesia
Authors: Suratno Suratno , Siswanta Dwi , Wahono Satriyo Krido , Aprilita Nurul Hidayat
Published: August 2022

Metals accumulation in threatened sharks’ meat represents a global health issue. The objective of the current study was to measure the concentration of six metals (Li, Ti, Ni, Cd, As, and Pb) using ICP-MS in threatened sharks’ meat of Rhizoprionodon acutus, Squalus hemipinnis, and Sphyrna lewini from Binuangeun Fish Auction in Lebak, Banten, Indonesia. The results showed that the concentration of Ni, Li, Cd, and Pb was below the acceptable levels for food sources for human consumption, except for As concentration (more than 30 fold higher). This study showed high levels of Ti concentration in all threatened sharks' meat. Overall, this study shows that an accumulation of Ti in sharks' meat should be considered a risk to the health of seafood consumers.
Total Synthesis of a Reversed-Bacicyclin Using a Combination of Solid- and Solution-Phase Methods
Authors: Maharani Rani , Firdausi Anastasya , Mayanti Tri , Harneti Desi , Nurlelasari Nurlelasari , Ishmayana Safri , Farabi Kindi , Supratman Unang , Hidayat Ace Tatang
Published: August 2022

Bacicyclin is a cyclic hexapeptide with antibacterial activity against Enterococcus faecalis and Staphylococcus aureus with minimum inhibition concentration (MIC) values of 8 and 12 µM, respectively. Studies on a reversed sequence of bacicyclin were conducted to investigate how the reversed peptide sequence affects its biological properties. A reversed-bacicylin, cyclo-(Gly-Leu-Val-Ile-Ala-Phe), was successfully synthesized by constructing the linear precursor on 2-chlorotrityl chloride resin using a Fmoc-based strategy. The HATU/HOAt reagent was applied in all peptidic bond formations, and the desired linear hexapeptide (82% yield) was cleaved off the resin using a mixture of trifluoroacetic acid:dichloromethane (2:8). The linear peptide was cyclized using 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxidehexa-fluorophosphate (HATU) as a coupling agent and diisopropylethylamine (DIPEA) as the base in a very dilute solution (0.001 M) in dichloromethane, then purified by octadecyl silica gel (ODS) column chromatography to obtain the reversed-bacicyclin (43.7% yield). The purity of the cyclic product was analyzed using analytical RP-HPLC (tR = 20.01 min), and characterized by HR-TOF-MS, 1H-NMR, and 13C-NMR. The biological activity of the reversed-bacicyclin is much lower compared to bacicyclin, indicating that the amino acid sequence of the cyclopeptide dictates the antibacterial activity. This finding gives additional information on the relationship between peptide sequence and biological properties.
Current Situation of Teaching Methods and Organization of Main Times of Physical Education Teachers of Foreign Trade University
Authors: Loc Vo Xuan
Published: August 2022

The study assessed the actual situation of teaching methods and organization of the main course of physical education of lecturers of Foreign Trade University. The research results will serve as a basis for applying measures to improve the learning efficiency of physical education for students at Foreign Trade University, contributing to improving the quality of physical education work in the school.
Kersen (Muntingia calabura L.) Ethanol Extract Repairs Pancreatic Cell Damage, Total Coliforms, and Lactic Acid Bacteria in Hyperglycemic Mice
Authors: Busman Hendri , Lestari Reza Pina , Rosa Emantis , Arifiyanto Achmad
Published: August 2022

Hyperglycemia is a condition in which the blood glucose levels exceed normal limits. Ethanol extract of Jamaican cherry leaves (Muntingia calabura L.) contains active components that have the potential to lower blood sugar levels and heal pancreatic cell damage in rats. Gut microbiota imbalance can cause immune system abnormalities, illnesses, and metabolic disorders, including diabetes. The aim of the present study was to determine whether an ethanol extract of Jamaican cherry leaves can repair pancreatic cell damage, as well as influence the total coliforms and lactic acid bacteria in hyperglycemic mice. In this study, 25 mice were randomly placed into five groups, which were then provided with food and drinking water. Alloxan in a dose of 160 mg/kg bw was administered to the positive control group and three treatment groups. Each of the three groups was then treated with the ethanol extract of Jamaican cherry leaves at doses of 300, 400, or 500 mg/kg bw for 14 days. The groups that received the extract were able to repair the pancreatic damage considerably by increasing the number of normal pancreatic cells. This was supported by histological observations. The total abundance of lactic acid bacteria in hyperglycemic mice was 1.08 ± 45 x 1010 CFU/g, which was substantially lower than that in mice treated with the extract. The overall coliform abundance in hyperglycemic mice was 4.37 ± 41 x 1010 CFU/g, which was higher than that in mice supplemented with the extract. Therefore, the administration of Jamaican cherry leaf ethanol extract on a regular basis can increase the abundance of cecum microbiota in hyperglycemic mice. Furthermore, this extract can be used as a natural alternative treatment for recovering pancreatic cell damage.
A Comparison Study of CBNAAT, Gene Xpert and Line Probe Assays in the Diagnosis of Tuberculosis in smear Negative Specimens
Authors: Vijay D. Danis , Meharaj S.H. Shifa , Jayanthi S. , Sujhithra A. , Vidhya R. , Meenakshi N. , Shanmuganathan Aruna
Published: August 2022

Tuberculosis (TB) is a serious and important public health issue to be addressed in India. Timely diagnosis of the drug resistance in tuberculosis is essential to ensure and initiate appropriate therapy. The detection of drug resistant Mycobacterium tuberculosis (MTB) in cases of smear-negative and clinical diagnosed pulmonary TB. A prospective case-control study was conducted on 473 pulmonary samples received at the tertiary care center from January 2019 to December 2019. All specimens were processed for microscopy and culture. CBNAAT- Gene Xpert and LPA Genotype MTBDRplus (VER 2.0) was used to confirm in smear-negative samples. Among the pulmonary samples, 52% smear-positive, and 48% smear-negative, 183 (43%) were found to be culture-positive by Lowenstein Jensen medium (LJ) and MGIT 960, 267 (63%) were positive CBNAAT and LPA n= 216 (51%) samples positive for the TUB band. The use of CBNAAT-Gene Xpert, Line Probe Assay Genotype MTBDR plus(VER 2.0) can be done from the samples directly and the diagnostic performance are more specific for detecting MTB in smear-negative specimens. This study suggests that LPA also helps in the diagnosis of MDR rapidly and in initiation of earlier treatment.
Broadband Dual-Polarized Aperture-Coupled Patch Antenna for 5G Applications
Authors: Khayal Bashar I. K. , Elrouby Alaa
Published: August 2022

Abstract: This paper presents the design of a dual-polarized aperture-coupled microstrip antenna array for Sub-6GHz 5G communication systems. The antenna operates at 3.5 GHz and consists of 4×4 square patches. The proposed 4×4 array antenna feds by aperture-coupled feed line provide broadband bandwidth to operate in the N78 sub-6GHz 5G frequency band. The dualpolarized is presented, which gives two communications channels. The antenna consists of three layers and is designed on Rogers RO4003C substrate with a dielectric constant of 3.55 and substrate thickness of 0.8 mm. The final design of the antenna array with an overall size of 269 mm × 269 mm × 12.5 mm, and the results show that the 4×4 array has a 10dB bandwidth between 3.3-3.8 GHz and a maximum gain of 14.9 dB at 3.5 GHz, and the isolation between the two ports was 30 dB. The proposed antenna's gain, radiation efficiency, and bandwidth satisfy the requirements of 5G base station systems.
Validity evidence studies of the Regulatory Emotional Self-Efficacy Scale in Brazil
Authors: Porto Noronha Ana Paula , De Medeiros Maciel Ana Cecília , Angeli dos Santos Acácia , Gurgel Azzi Roberta
Published: August 2022

Self-efficacy for emotion regulation is understood as the perceived capability to regulate the negative affect and to express the positive ones. This study aimed at the validity evidence for the Regulatory Emotional Self-Efficacy Scale in the Brazilian context through two studies. In the first one, participants were 41 students from middle school (M = 13.49; SD = 1.52), being 58.5 % male. Results indicated a few adjustments in some items. The second study had 932 participants from two cities: one from Southeast Brazil and one from the North. The students were from middle and high schools being 50.3 % (n = 469) female. Their ages ranged from 13 to 23 years old (M = 16.50; SD = 1.52). After analysis through structural equation modeling, results indicated that the dimensions of the scale have a good fit according to the theoretical model with good accuracy indexes, thus confirming the validity evidence for this instrument, being reliable to be used in Brazil.
Bantuan Luar Negeri sebagai Bentuk Implementasi Economic Persuasion Amerika Serikat ke Sudan
Authors: Putri Sindy Yulia
Published: August 2022

The foreign aid provided by the United States in the Darfur’s conflict, Sudan has received attentions from the global community. This assistance reflected on the policy of economic persuasion as a number of the United States’ political and economic interests in Sudan. The US was assumed to be inconsistent. The US still committed to provide aids to Sudan whereas it imposed economic sanctions on Sudan. A wide variety of aids included humanitarian assistance, food, sanitation, technical assistance, conditional loans, grants, and so forth. This paper has used a descriptive qualitative approach, because this study only described the US interests behind a number of foreign aid’s distributions, when the US carried out economic sanctions against Sudan. The result of this study is that the US empowered foreign aid as a form of realization of economic persuasion, especially a structural economic linkage. Although the US enforced economic sanctions on Sudan, the US still distributed foreign aid to that country. The US had ambitions to obtain an access to energies such as oil and gas, as well as to maintain a political stability in the African region. The US played a role in minimizing the Darfur’s conflict by providing a range of foreign assistances not only to normalize diplomatic relations with Sudan, but also to maintain sustainable partnerships with among countries in an African region.
Preparação do professor para o Ensino de Alunos com Deficiência: Estudo de Caso em uma Instituição Federal de Ensino
Authors: Mafra Samantha Marina , Kieling Sueli Farias
Published: August 2022

A educação inclusiva diz respeito a oportunizar o direito de educação para todos. Assim, torna-se primordial a preparação do professor para o atendimento adequado aos alunos com deficiência. O presente estudo foi desenvolvido com o objetivo de averiguar a percepção dos formandos de um curso de especialização em docência profissional em relação à preparação para lecionar para alunos com deficiência. Para tanto, foi analisada a Matriz Curricular do curso, a fim de identificar as unidades curriculares que abordam a inclusão educacional. De forma complementar, foi realizada uma pesquisa com os formandos de 2020, por meio de questionário, com o objetivo de obter a percepção deles quanto à capacitação recebida. A pesquisa é classificada como qualitativa-quantitativa, por meio de análise documental, levantamento e estudo de caso. A partir das análises dos dados, observa-se obtenção de conhecimentos acerca de adaptação de instrumentos de avaliação para alunos com deficiência, bem como relativos às atividades diferenciadas para o atendimento educacional especializado (adequação de materiais, comunicação alternativa e informática acessível). Os resultados indicam que o curso apresenta capacitação suficiente para que os futuros docentes atuem com alunos com deficiência, embora uma ampliação na abordagem do tema, realização de oficina, atividades práticas e outras melhorias seriam bem recebidas.
Corporate social responsibilities and the well-being of rural dwellers: The Lafarge Cement Company’s example
Authors: Anam Asari Effiong , Opoh Fredrick Awhen , Akongi Unimke Sylvester , Eshiotse Emmanuel , Obeten Ude Bassey , Okon Ruth Bassey , Ofem Nnana Okoi , Ikpeme Bassey Ballantyne , Wilson Nwosu Uchechukwu , Okpa John Thompson
Published: August 2022

Using the Lafarge Cement Company’s example, the study examined the impact of corporate social responsibility (CSR) on the well-being of rural dwellers in Nigeria. The design adopted is cross-sectional, where quantitative and qualitative methods were applied in obtaining data from one thousand one hundred and four (1104) respondents from selected communities in the Southern Senatorial District of Cross River State, Nigeria. The research used a multi-stage sampling technique. Data were then analysed using descriptive statistics such as percentages and frequency tables. At the same time, the qualitative data were analysed using content analysis techniques. However, the findings revealed that 62.1% of the respondents reported that they are aware of the existing projects executed by Lafarge Cement Company. While 36.4% of the respondents reported construction and rehabilitation of roads as the projects with the highest attention. The findings of the study further showed that 36.4% of the respondents identified improved income and wealth as the most impacted aspect of their well-being. Beyond investing in infrastructure, the study recommended that more resources be invested in young people’s human capital development in rural areas. This will help in achieving sustainable development in rural areas
Low genetic diversity and significant pedigree differentiation characterize the evolutionary history of Camellia drupifera in China
Authors: qi huasha , sun xiuxiu , Yan Wuping , Ye Hang , Chen Jiali , Yu Jing , Dai Jun , Wang Chunmei , Xia Tengfei , Chen Xuan , Zheng daojun
Published: August 2022

Camellia drupifera is a main tea-oil Camellia species, and understanding
its genetic variation, origin and evolution will facilitate protection
and utilization of its genetic resources. However, the differentiation,
genetic variation, origin and evolution of C. drupifera remains unknown.
Here, SRAP markers and chloroplast sequences of 32 C. drupifera
populations were used to determine genetic variation and differentiation
and infer the origin and evolutionary history of the species. Genetic
diversity is low (H=0.200, Hd=0.861, Pi=0.00238), with obvious pedigree
geographical structure among populations (Nst=0.612, Gst=0.117). Genetic
differentiation is high (Gst=0.400, SRAP; Fst=0.68080, cpDNA), but gene
exchange is low (Nm = 0.749 for nrDNA, Nm = 0.358 for cpDNA). The
phylogenetic tree and PCA showed that this differentiation is mainly due
to separation of the Hainan Island and mainland populations.
Geographical isolation and island effects caused the pedigree structure,
with large genetic differentiation, and reduced genetic diversity.
STRUCTURE analysis revealed that compared with the Hainan Island
population, the mainland population has a single genetic background. The
TCS network showed that H17 was the original haplotype on Hainan Island;
the H41 haplotype was important in the expansion of C. drupifera from
Hainan Island to mainland China. Haplotype historical dynamics revealed
expansion of the Hainan Island populations (Tajima’s D=-2.31467**, Fu’s
Fs=-2.45270*). Comprehensive analysis suggests that C. drupifera
originated on Hainan Island and expanded its range to mainland China.
These results provide a scientific basis for the protection, development
and utilization of C. drupifera resources and a good example of how
geographic isolation and island effects can drive plant lineage
differentiation.
The impact of anaphylaxis on the quality of life and mental health of adults
Authors: Knibb Rebecca , Huissoon Aarnoud , Baretto Richard , Ekbote Anjali , Onyango-Odera Sham , Screti Cassandra , L Kristina Newman , KRISHNA MAMIDIPUDI THIRUMALA
Published: August 2022

Background. Anaphylaxis is a severe and potentially
life-threatening allergic reaction which has a detrimental impact on
quality of life (QoL), however little is known about the impact of
anaphylaxis, across the various causes, on adults. The aim of this study
was to assess the impact of anaphylaxis on QoL and mental health in
adults. Methods. Participants (n=142; 60% female) were
recruited from a regional allergy centre (Birmingham, U.K) following
systematic specialist evaluation. They completed measures of generic QoL
(WHOQoL BREF), anaphylaxis specific QoL (A-QoL-Adults), anxiety and
depression (HADS) and stress (PSS). Results. Anaphylaxis
triggers were mainly to medication or during general anaesthesia
(29.6%), food (29.6%), wasp or bee venom (16.2%), or were spontaneous
(21.1%). Adults with anaphylaxis had significantly poorer general QoL
and stress than published data from a healthy population. Females had
significantly poorer anxiety and depression than norm data (all
p<0.01). Poorer anaphylaxis specific QoL was significantly
related to greater stress, depression, anxiety, poorer general QoL and
demographic and clinical variables such as age, gender, severity of
anaphylaxis, presence of other atopic conditions (all p<0.05).
Regression analysis showed that anxiety, depression and number of
anaphylactic reactions were significant predictors for anaphylaxis
specific QoL. Conclusions. Anaphylaxis has an adverse impact on
QoL and mental health of adults across different triggers. Anxiety,
depression and number of reactions in particular seem to be important in
explaining the impact on QoL and should be of particular note for
clinicians managing adults with this condition, and when considering
specialist psychological support.
Inhibition of root growth and carbon metabolism of apple M97337 rootstock under high nitrate stress is alleviated by adjusting potassium supply strategy
Authors: Xu Xinxiang , Zhang Xuelin , Liu Chunling , Qin Hanhan , Sun Fangxuan , Liu Jingquan , Lyu Mengxue , Xing Yue , Tian Ge , Zhu Zhanling , Jiang Yuanmao , Ge Shunfeng
Published: August 2022

Nitrogen (N) is an essential element for plant growth, development, and
metabolism. In apple production, the excessive use of N fertilizer may
cause high N stress. Whether high N stress can be alleviated by
regulating potassium (K) supply is unclear. A hydroponics experiment was
conducted herein to test the influence of different N and K conditions
on the root morphology and physiology of apple M9T337 rootstocks. The
results showed that high nitrate-N conditions caused the dysregulation
of N/K balance, hormone content, and antioxidant metabolism, resulting
in damage to the root cortex structure. High nitrate conditions caused
stomatal closure and reduced mesophyll conductance ( g) and the maximum carboxylation efficiency ( V), thus increasing photosynthetic limitations, and
also reduced the expression of sugar transporter proteins (
MdSOT1, MdSOT2, and MdSUT1), leading to a lower
soluble sugar content in the root system, which was detrimental to root
growth. Further analysis found that appropriately increasing the K
supply (10 mM) enhanced the superoxide dismutase, peroxidase, and
ascorbate peroxidase activities, reduced the malondialdehyde and H
O contents, and protected the root
structure. It also optimized the net photosynthetic rate ( A), increased sugar transporter protein expression and
sugar-metabolizing enzyme activity in the roots, promoted the transport
of photosynthetic products such as sorbitol and sucrose from the leaves
to the roots, and increased the soluble sugar content in the roots. In
summary, our data show that an appropriate increase in the K supply (10
mM) alleviated the root inhibition of high N through regulating
physiological metabolic activities such as the antioxidant system and
carbon metabolism. These findings support the use of N and K for
alleviating high-N stress.
RECURRENT CATATONIA DUE TO EPISODIC OBSESSIVE-COMPULSIVE DISORDER: A CASE REPORT
Authors: Das Soumitra , Prasad Sakshi , Fichadia Palak Atul , Shrestha Abhigan , Williams Ozge C. Amuk , Bachu Anil
Published: August 2022

Our study shows a possible link between OCD and catatonia. Studies are
needed in order to determine the pathophysiology of catatonia and the
mechanism of ECT so that more beneficial therapeutics can be developed.
A combination of ECT and antidepressants with ERP therapy for recurrent
catatonia with OCD has efficacy