bluuebunny/crossref_metadata_2025 huggingface dataset:
A qualitative examination of naloxone access in three states: Connecticut, Kentucky, and Wisconsin
Authors: Spector Antoinette L. , Galletly Carol L. , Christenson Erika A. , Montaque H. Danielle Green , Dickson-Gomez Julia
Published: July 2022

Background

Prevention of opioid-involved overdose deaths remains a public health priority in the United States. While expanding access to naloxone is a national public health strategy, it is largely implemented at the state and local level, where significant variability in policies, resources, and norms exist. The aims of the current study were to examine the social context of naloxone access in three different states (Connecticut, Kentucky, Wisconsin) from the perspectives of key informants (first responders, harm reduction personnel, and pharmacists), who play some role in dispensing or administering naloxone within their communities.

Methods

Interviews were conducted with key informants who were in different local areas (urban, suburban, rural) across Connecticut, Kentucky, and Wisconsin. Interview guides explored the key informants’ experiences with administering or dispensing naloxone, and their perspectives on opioid overdose prevention efforts in their areas. Data analysis was conducted using multistage inductive coding and comparative methods to identify dominant themes within the data.

Results

Key informants in each of the three states noted progress toward expanding naloxone access, especially among people who use opioids, but also described inequities. The key role of harm reduction programs in distributing naloxone within their communities was also highlighted by participants, as well as barriers to increasing naloxone access through pharmacies. Although there was general consensus regarding the effectiveness of expanding naloxone access to prevent overdose deaths, the results indicate that communities are still grappling with stigma associated with drug use and a harm reduction approach.

Conclusion

Findings suggest that public health interventions that target naloxone distribution through harm reduction programs can enhance access within local communities. Strategies that address stigmatizing attitudes toward people who use drugs and harm reduction may also facilitate naloxone expansion efforts, overall, as well as policies that improve the affordability and awareness of naloxone through the pharmacy.
A controlled evaluation of the effect of social prescribing programs on loneliness for adults in Queensland, Australia (protocol)
Authors: Dingle G. A. , Sharman L. S. , Hayes S. , Chua D. , Baker J. R. , Haslam C. , Jetten J. , Haslam S. A. , Cruwys T. , McNamara N.
Published: July 2022

Background

In social prescribing, link workers support individuals whose persistent health problems are exacerbated by loneliness by connecting them to community-based social activities. This approach is well established in the UK and is gaining attention in Australia. However, a major limitation of research to date has been a lack of theoretically informed and rigorous evaluations of social prescribing. We will address these points in this study, applying a social identity framework to examine the effects of group-based social prescribing (SP) activity compared to primary care treatment as usual (TAU).

Methods

Ninety participants experiencing loneliness recruited from primary care services and community centres across five sites in Southeast Queensland will be assigned to one of two conditions (SP, TAU) and assessed at two timepoints (baseline, + 8 weeks). Individuals will be aged 18 years and over, have sufficient English language skills to provide consent, and at the time of recruitment they will not be experiencing acute symptoms or social issues that require urgent intervention. Primary outcomes are loneliness, mental well-being, and health service use (total number of GP, hospital, and allied health visits in the past 3 months). Secondary outcomes will assess social group processes, including number of important social groups, new group identification, multiple identity compatibility, and group-based support and emotion regulation.

Discussion

This study will provide comprehensive data about the extent to which, and how, social prescribing to community-based group activities may help people to feel less lonely, more socially integrated, and healthy over the first 8 weeks. If effective, this social identity-informed model of social prescribing can be disseminated in communities across Australia.

Trial registration

ANZCTR, Registered 8 June 2022 - Retrospectively registered, https://www.anzctr.org.au/ACTRN12622000801718.aspx
Estimating the effects of policies on infertility prevalence worldwide
Authors: Zhang Xiaochen , Guan Quanquan , Yu Qiurun , Xiao Wenwen , Chen Ziyu , Dong Chao , Deng Siting , Zhuang Yin , Xia Yankai
Published: July 2022

Background

Infertility has troubled millions of people worldwide while always being an ignored issue. The high cost of treatment or lack of services placed a barrier to the alleviation of infertility status. Governments play a significant role to promote infertility-related policies for better access to infertility services and comprehensive supports for infertile people.

Methods

Data of infertility status indicators and infertility-related policies in ten representative countries were collected. An infertility-related policy system was established, then classification and quantification were processed according to specific criteria, and different policy implementation patterns were identified. The effectiveness of specific infertility-related policy and various patterns on infertility prevalence relief between 1990 and 2017 were evaluated via generalized linear models and analyses of covariance for the first time.

Results

Economic support policies would be less prioritized compared with social security policies, while economic support policy had a significant positive role in the decline of female infertility prevalence (β = -2·16, p = 0·042). In detail, insurance coverage and economic reward policies were crucial (β = -3·31, p = 0·031; β = -4·10, p = 0·025) with adjusted with covariates. The effect of economic support-oriented pattern was relatively better than other patterns for both male and female infertility prevalence relief. Nevertheless, the effectiveness of gradual-promotion pattern seemed preferable for male infertility prevalence relief while was similar with simultaneous-promotion pattern for females.

Conclusions

Our data-driven analysis revealed that insurance coverage and economic reward policies played the pivotal role in moderation of female infertility status. Economic support-oriented pattern and gradual-promotion pattern were preferable when promoting infertility-related policies.
Stelara struck: a case of noninfectious pneumonitis secondary to ustekinumab
Authors: Despotes Katherine A. , Vigeland Christine L.
Published: July 2022

Background

We describe a case of acute hypoxic respiratory failure due to drug induced lung disease secondary to ustekinumab, which is a monoclonal antibody used to treat psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Case presentation

A 33-year-old man with a history of Crohn’s disease presented with fevers, myalgias, and abdominal pain, and subsequently developed acute hypoxemic respiratory failure approximately 2 weeks after restarting ustekinumab for his Crohn’s disease. Cross-sectional chest imaging showed ground glass opacities and bilateral consolidations. Due to progressive hypoxia, he ultimately required intubation and mechanical ventilation. Broad infectious and autoimmune work up was negative, making drug induced interstitial lung disease (DILD) the leading consideration. He was treated with high dose steroids with dramatic improvement in his respiratory status. At follow up, his imaging findings had largely resolved, and his pulmonary function tests were normal.

Conclusions

For patients presenting with acute hypoxic respiratory failure, it is critical to identify the underlying cause. In addition to testing for common respiratory infections that can cause respiratory failure, patients should also be evaluated for risk factors for developing atypical or opportunistic infections as well as inflammatory pneumonitis. Due to receiving ustekinumab, our patient was both at risk for developing an opportunistic infection as well as DILD. Although rare, DILD is a recognized toxicity of ustekinumab. Ustekinumab can cause significant lung injury, as in our patient, but with steroids and avoidance of future doses of the medication, our patient demonstrated good recovery. Reassuring outcomes have similarly been described in the literature; however, this case provides further details about outcomes with long-term follow-up clinical, imaging, and pulmonary function testing data available. We recommend consideration of high dose steroids for these patients for whom DILD is suspected.
Ectopic ACTH-producing neuroendocrine tumor occurring with large recurrent metastatic pheochromocytoma: a case report
Authors: Saishouji Fumi , Maeda Sarie , Hamada Hideaki , Kimura Noriko , Tamanoi Ai , Nishida Saiko , Sakaguchi Masaji , Igata Motoyuki , Yokoo Kiho , Kawakami Fumi , Araki Eiichi , Kondo Tatsuya
Published: July 2022

Background

Ectopic ACTH-dependent Cushing syndrome is rarely caused by pheochromocytoma (PCC). Glucocorticoid-regulated positive feedback loops in ACTH and catecholamines were proposed in some similar cases.

Case presentation

We present here an 80-year-old man who had previously undergone surgery for a left adrenal PCC and newly developed severe hypertension, hypokalemia, and typical Cushingoid manifestations. Investigations revealed hyperglycemia, hypokalemia, and extremely high catecholamines and their metabolites, ACTH and cortisol. Imaging modalities showed a recurrent large left adrenal mass positively visualized with 123I-metaiodobenzylguanidine as well as somatostatin receptor scintigraphy. Surgical interventions were not indicated; thus, metyrapone, phentolamine, and doxazocin were initiated, which successfully controlled his symptoms and biochemical conditions. With the evidence that metyrapone administration decreased ACTH and catecholamine levels, the existence of positive feedback loops was speculated. During the terminal stages of the disease, additional metyrosine treatment successfully stabilized his physiological and biochemical conditions. Upon the patient’s death, pathological autopsy was performed. Immunohistochemical analysis indicated that the tumor appeared to be co-positive with tyrosine hydroxylase (TH) as well as ACTH in most tumor cells in both PCC and liver metastasis. Most cells were clearly positive for somatostatin receptor 2 staining in the membrane compartment. The dense immunostaining of ACTH, TH, dopamine-β-hydroxylase and the large tumor size with positive feedback loops may be correlated with high levels of ACTH and catecholamines in the circulation.

Conclusions

We experienced a case of severe ectopic ACTH producing the largest reported recurrent malignant left PCC with liver metastases that presented positive feedback loops in the ACTH/cortisol and catecholamine/cortisol axes. Clinicians should be aware of the paradoxical response of ACTH on metyrapone treatment and possible steroid-induced catecholamine crisis.
Interoceptive accuracy is related to the psychological mechanisms of the burning mouth syndrome: a cross-sectional study
Authors: Yoshino Atsuo , Otsuru Naofumi , Doi Mitsuru , Maekawa Toru , Sasaoka Takafumi , Yamawaki Shigeto
Published: July 2022

Background

Different perspectives are needed to understand the pathophysiology of burning mouth syndrome (BMS), including physiological and psychological standpoints. The significance of interoception in chronic pain has been suggested. However, few studies have investigated this relationship in BMS. Therefore, we examined the role of interoception in BMS.

Methods

This is a cross-sectional study. BMS patients (N = 64) participated in the study. We used interoceptive accuracy (IAc) based on the heartbeat counting task. Then, participants were divided into high and low IAc groups, and their scores on clinical assessment including pain and psychological evaluation were compared.

Results

The Visual Analogue Scale scores indicating pain in low IAc patients, but not high IAc patients, were positively correlated with the Beck Depression Inventory-Second Edition (BDI-II) and the State-Trait Anxiety Inventory-State (STAI-S) Scores.

Conclusions

Interoception might play a role in the pathophysiology of BMS.
MRI compatibility of orthodontic brackets and wires: systematic review article
Authors: Dobai Adrienn , Dembrovszky Fanni , Vízkelety Tamás , Barsi Péter , Juhász Fanni , Dobó-Nagy Csaba
Published: July 2022

Background

Before the magnetic resonance imaging (MRI) examination fixed orthodontic devices, such as brackets and wires, cause challenges not only for the orthodontist but also for the radiologist. Essentially, the MRI-safe scan of the fixed orthodontic tools requires a proper guideline in clinical practice. Therefore, this systematic review aimed to examine all aspects of MRI-safe scan, including artifact, thermal, and debonding effects, to identify any existing gaps in knowledge in this regard and develop an evidence-based protocol.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement was used in this study. The clinical question in “PIO” format was: “Does MRI examination influence the temperature of the orthodontic devices, the size of artifacts, and the debonding force in patients who have fixed orthodontic bracket and/or wire?” The search process was carried out in PubMed, PubMed Central, Scopus, and Google Scholar databases. The search resulted in 1310 articles. After selection according to the eligibility criteria, 18 studies were analyzed by two reviewers. The risk of bias was determined using the Quality In Prognosis Studies tool.

Results

Out of the eligible 18 studies, 10 articles examined the heating effect, 6 were about the debonding effect, and 11 measured the size of artifact regarding brackets and wires. Considering the quality assessment, the overall levels of evidence were high and medium.

The published studies showed that heating and debonding effects during MRI exposure were not hazardous for patients. As some wires revealed higher temperature changes, it is suggested to remove the wire or insert a spacer between the appliances and the oral mucosa. Based on the material, ceramic and plastic brackets caused no relevant artifact and were MRI-safe. Stainless steel brackets and wires resulted in susceptibility artifacts in the orofacial region and could cause distortion in the frontal lobe, orbits, and pituitary gland. The retainer wires showed no relevant artifact.

Conclusions

In conclusion, the thermal and debonding effects of the fixed orthodontic brackets and wires were irrelevant or resoluble; however, the size of the artifacts was clinically relevant and determined most significantly the feasibility of fixed brackets and wires in MRI examination.
Obtaining patients’ medical history using a digital device prior to consultation in primary care: study protocol for a usability and validity study
Authors: Albrink Klara , Joos Carla , Schröder Dominik , Müller Frank , Hummers Eva , Noack Eva Maria
Published: July 2022

Background

With the help of digital tools patients’ medical histories can be collected quickly and transferred into their electronic medical records. This information can facilitate treatment planning, reduce documentation work, and improve care. However, it is still unclear whether the information collected from patients in this way is reliable. In this study, we assess the accuracy of the information collected by patients using an app for medical history taking by comparing it with the information collected in a face-to-face medical interview. We also study the app’s usability from the patients’ point of view and analysing usage data.

Methods

We developed a software application (app) for symptom-oriented medical history taking specialized for general practice. Medical history taking will take place involving patients with acute somatic or psychological complaints (1) using the app and (2) verbally with trained study staff. To assess the perceived usability, patients will complete a questionnaire for the System Usability Scale. We will collect sociodemographic data, information about media use and health literacy, and app usage data.

Discussion

Digital tools offer the opportunity to improve patient care. However, it is not self-evident that the medical history taken by digital tools corresponds to the medical history that would be taken in an interview. If simply due to a design flaw patients answer questions about signs and symptoms that indicate possible serious underlying conditions ‘wrong’, this could have severe consequences. By additionally assessing the app’s usability as perceived by a diverse group of patients, potential weaknesses in content, design and navigation can be identified and subsequently improved. This is essential in order to ensure that the app meets the need of different groups of patients.

Trial registration German Clinical Trials Register DRKS00026659, registered Nov 03 2021. World Health Organization Trial Registration Data Set, https://trialsearch.who.int/Trial2.aspx? TrialID = DRKS00026659.
The immediate and short-term impact of COVID 19 infections on nurses in a UAE hospital
Authors: Al Qawasmeh Khaled , Al Amiri Nabeel , Al Nuaimi Salma Omar
Published: July 2022

Background/Aims

Nurses were on the front line against the COVID 19 pandemic, fighting to save human lives. Many nurses sacrificed their well-being and social life to win the battle. In consequence, many nurses have been infected with the virus around the Globe. This study aims to determine the immediate and short-term physical, psychological, and social impact of COVID 19 infection on nurses and midwives retrospectively. On the other hand, it aims to find the effect of COVID 19 stigma on the self-esteem of the infected nurses.

Methods

To achieve this goal, the authors used an exploratory, mixed-method design with a sample of nurses and midwives working in a tertiary hospital in UAE who has been infected with the COVID 19 virus and recovered. The authors have used the qualitative results to explain and interpret the findings of the quantitative findings. The data were collected through distributing the quantitative survey to participants and then it was followed by conducting semi-structured interviews.

Results

The careful exploration of the experiences of nurses infected with the COVID 19 virus suggested a simple model that manages the patients in hospitals and at homes, including improving self-efficacy and patient coping, providing the basic nursing skills to patients and families, providing continuous psychological support, and providing high standards of health care.

Conclusion

The new suggested model will maintain a positive status of wellbeing amongst infected patients during the infection time and in 3–6 months after the infection.
The ReCoN intervention: a co-created comprehensive intervention for primary mental health care aiming to prevent involuntary admissions
Authors: Wormdahl Irene , Hatling Trond , Husum Tonje Lossius , Kjus Solveig Helene Høymork , Rugkåsa Jorun , Brodersen Dorte , Christensen Signe Dahl , Nyborg Petter Sundt , Skolseng Torstein Borch , Ødegård Eva Irene , Andersen Anna Margrethe , Gundersen Espen , Rise Marit B.
Published: July 2022

Background

Reducing involuntary psychiatric admissions is a global concern. In Norway, the rate of involuntary admissions was 199 per 100,000 people 16 years and older in 2020. Individuals’ paths towards involuntary psychiatric admissions usually unfold when they live in the community and referrals to such admissions are often initiated by primary health care professionals. Interventions at the primary health care level can therefore have the potential to prevent such admissions. Interventions developed specifically for this care level are, however, lacking. To enhance the quality and development of services in a way that meets stakeholders’ needs and facilitates implementation to practice, involving both persons with lived experience and service providers in developing such interventions is requested.

Aim

To develop a comprehensive intervention for primary mental health care aiming to prevent involuntary admissions of adults.

Methods

This study had an action research approach with a participatory research design. Dialogue conferences with multiple stakeholders in five Norwegian municipalities, inductive thematic analysis of data material from the conferences, and a series of feedback meetings were conducted.

Results

The co-creation process resulted in the development of the ReCoN (Reducing Coercion in Norway) intervention. This is a comprehensive intervention that includes six strategy areas: [1] Management, [2] Involving Persons with Lived Experience and Family Carers, [3] Competence Development, [4] Collaboration across Primary and Specialist Care Levels, [5] Collaboration within the Primary Care Level, and [6] Tailoring Individual Services. Each strategy area has two to four action areas with specified measures that constitute the practical actions or tasks that are believed to collectively impact the need for involuntary admissions.

Conclusions

The ReCoN intervention has the potential for application to both national and international mental health services. The co-creation process with the full range of stakeholders ensures face validity, acceptability, and relevance. The effectiveness of the ReCoN intervention is currently being tested in a cluster randomised controlled trial. Given positive effects, the ReCoN intervention may impact individuals with a severe mental illness at risk of involuntary admissions, as more people may experience empowerment and autonomy instead of coercion in their recovery process.
Quantifying the climate benefits of a virtual versus an in-person format for an international conference
Authors: Lewy Jacqueline R. , Patnode Casey D. , Landrigan Philip J. , Kolars Joseph C. , Williams Brent C.
Published: July 2022

Background

Academic institutions across the globe routinely sponsor large conferences. During the COVID-19 pandemic, many conferences have used all- or partially virtual formats. The conversion of the 2021 Consortium of Universities for Global Health (CUGH) conference, originally planned in-person for Houston, TX USA to an all-virtual format provided an opportunity to quantify the climate-related impacts of in-person versus virtual conferences.

Methods

From the 2021 CUGH conference registration data, we determined each registrant’s distance from Houston. Using widely available, open-source formulas, we calculated the carbon footprint of each registrant’s round-trip drive or flight had they traveled to Houston. We assumed that registrants traveling more than 300 miles would have flown, with the remainder traveling by automobile.

Results

Of 1909 registrants, 1447 would have traveled less than 4000 miles, and 389 would have traveled more than 10,000 miles round trip. Total travel-related carbon emissions were estimated at 2436 metric tons of CO2, equivalent to the conservation of 2994 acres of forest for a year.

Conclusions

Organizations can now readily quantify the climate cost of annual conferences. CUGH’s annual international conference, when held in-person, contributes significantly to carbon emissions. With its focus on promoting global health equity, CUGH may play a lead role in understanding the pros and cons for planetary health of in-person versus virtual conferences. CUGH and other organizations could routinely measure and publish the climate costs of their annual conferences.
Integration of single-cell multi-omics data by regression analysis on unpaired observations
Authors: Yuan Qiuyue , Duren Zhana
Published: July 2022

Despite recent developments, it is hard to profile all multi-omics single-cell data modalities on the same cell. Thus, huge amounts of single-cell genomics data of unpaired observations on different cells are generated. We propose a method named UnpairReg for the regression analysis on unpaired observations to integrate single-cell multi-omics data. On real and simulated data, UnpairReg provides an accurate estimation of cell gene expression where only chromatin accessibility data is available. The cis-regulatory network inferred from UnpairReg is highly consistent with eQTL mapping. UnpairReg improves cell type identification accuracy by joint analysis of single-cell gene expression and chromatin accessibility data.
High-flow nasal cannula oxygen therapy versus noninvasive ventilation for patients with blunt chest trauma: protocol for a randomized controlled trial
Authors: Zhu Qingcheng , Wang Bingxia , Li Yujie , Ling Bingyu , Xu Jun , Jin Kui , Sun Ming , Zhu Jianjun , Walline Joseph , Wang Yunyun , Cao Peng , Guo Xiaojuan , Tan Dingyu
Published: July 2022

Background

High-flow nasal cannula oxygen therapy (HFNC) is recommended by some scholars as an optimized respiratory support method for blunt chest trauma (BCT) patients. The basis of this recommendation is limited, however, and the efficacy of HFNC or noninvasive ventilation (NIV) in BCT patients has not yet been rigorously explored. This study aims to determine if HFNC is non-inferior to NIV in reducing treatment failure in moderate to severe BCT patients with acute respiratory failure.

Methods

This will be a prospective, open-label, multicenter, non-inferiority, randomized controlled trial. Moderate to severe BCT patients with acute respiratory failure (100mmHg < PaO2/FiO2≦ 200mmHg) who do not need immediate intubation will be randomized to HFNC or NIV within 48 h after trauma. The primary outcome is treatment failure, defined as invasive ventilation or a switch in respiratory support modality (from HFNC to NIV or vice-versa). Secondary outcomes include arterial blood gas analysis and vital signs at 2 and 12 h after initiating HFNC or NIV treatment, as well as patients’ comfort scores, dyspnea scores, daily number of nursing airway care interventions, incidence of pneumonia or pneumothorax, facial skin breakdown, duration of NIV or HFNC, 28-day mortality, and total ICU and hospital lengths of stay. Based on anαerror of 5% and aβerror of 80%, with a non-inferiority limit of 9%, a sample size of 562 will be required to accomplish the trial goal, considering potential patient dropouts and nonparametric analysis.

Discussion

We hypothesize that HFNC will be non-inferior to NIV in reducing treatment failure in moderate to severe BCT with acute respiratory failure. The results should be useful for judging whether HFNC could be an effective alternative to NIV to treat moderate to severe BCT patients, especially for those who do not tolerate or have contraindications for NIV.

Trial registration

Chinese Clinical Trial RegistryChiCTR1800017313. Registered on July 24, 2018.
Validation of a modified QuEChERS method for the extraction of multiple classes of pharmaceuticals from soils
Authors: De Mastro Francesco , Cocozza Claudio , Traversa Andreina , Cacace Claudio , Mottola Francesca , Mezzina Alessandra , Brunetti Gennaro
Published: July 2022

Background

The quick, easy, cheap, effective, rugged, and safe (QuEChERS) method can be employed for multi-residue analyses instead of traditional extraction methods due to its advantages in terms of extraction time and required equipment. A modified version of the QuEChERS method has been developed for quantifying eight pharmaceuticals belonging to different classes in three real soils with different chemical properties. Firstly, the soils have been polluted with all contaminants and the recoveries were determined by liquid chromatography tandem–mass spectrometry. Due to similar recoveries from the three soils, the validation of the method has been carried out only on a soil by determining linearity, recovery, precision, limit of detection (LOD) and limit of quantification (LOQ) values. A matrix-matched calibration for the soil has been adopted in order to avoid the matrix effect and three levels of fortification (50, 100 and 500 µg L−1) were used.

Results

The recovery of all pharmaceuticals, with the exception of tetracycline, from any soil was between 72 and 113%. In the validation procedure, recoveries of fortified samples ranged from 80 to 99%, the relative standard deviations ranged between 1.2 and 11.8%, and the LOQ between 20 and 36.9 μg kg−1.

Conclusion

The results of the present study confirmed the validity of the modified QuEChERS method for the extraction of pharmaceuticals from soils in the range 50–500 μg kg−1.

Graphical Abstract
Features of translation of scientific terms in the genetic field into Ukrainian
Authors:   National University ", Matiiuk V. V. ,   Yuri Kondratyuk Poltava Polytechnic", Kushnirova T. V. ,   National University "Yuri Kondratyuk Poltava Polytechnic"
Published: July 2022

The article considers scientific terms and methods of their translation on the example of a number of articles in the field of genetics. The experience and practical work of leading specialists in the field of genetics and translation are analyzed. The aim of the work was a thorough analysis of the translation of scientific terms on genetic topics. Currently, there is a problem of unification of selection and genetic terminology, which is actively developing today. The term becomes the core of the genetic text, because it is from understanding a certain concept, you can come to understand the full test. Usually the genetic text is characterized by one and multi-component vocabulary, in particular 1, 2, 3 component terms, which are translated by transliteration, transcription and tracing; sometimes all these methods are combined to form a corresponding concept. The article analyzes the translation of proper names of genetic topics. In most cases in genetics, when translating proper names into another language, translators use the method of transliteration, sometimes using tracing. In this case, the proper names of the source language are transmitted in the letters of the Ukrainian alphabet without considering the peculiarities of pronunciation. There are cases when the dictionary does not have an exact correspondence to a certain term, or the use of these methods is illogical, then translators resort to other translation transformations, especially when the terminology is new. The paper notes that conditionally all texts can be divided into two groups: texts with already known concepts and texts that introduce new concepts, which are usually expressed in new terms. The article notes that a promising task of modern researchers is to create bilingual dictionaries and reference books in the genetic field, which will unify the terminological apparatus of a particular field.
Exployting TikTok in teaching English: SWOT analysis of application
Authors:   Sumy State University, Otroshchenko L. S. , Medvedovska D. O. ,   Sumy State University
Published: July 2022

Social media applications are fast becoming more and more popular in the educational process nowadays. This paper aims to explore the potential of the newly emerging social media application TikTok utilization in teaching English. TikTok is both a learning platform and a social network. This active learning method has unique features that attract students to use it. TikTok’s success is primarily due to the interactive and highly engaging nature of the audiovisual content that dominates its platform. Users often spend hours scrolling through their feeds, and popular channels boast millions of followers. The advantages of integrating TikTok into the educational process inside and outside of the classroom have been examined in this paper. It has many benefits and is effective in helping students and teachers in teaching and learning activities. Research indicates that this is an effective tool for students and teachers alike. It breaks the lessons down so users can absorb it as part of an “everyday scroll”. Different ways of TikTok implementation while teaching English have been presented. In addition, the experience of TikTok usage for educational purposes during English lessons at Sumy State University has been described. How one can harness social media in that journey will depend on his individual goals. Furthermore, more and more language teachers take to social media platforms. However, some threats and concerns about TikTok usage have been mentioned in the paper.
English idioms with coordinate phrases as representatives of the English language picture of the world
Authors:   State Institution Luhansk Taras Shevchenko National University, Komlyk N. Yu.
Published: July 2022

This article is dedicated to the study of the semantic content of coordinate phrases and their role in the process of creating English idioms as representatives of the worldview of English society. The author outlines the key aspects of the interpretation of the linguistic picture of the world in domestic and foreign linguistics. The place and role of phraseological units, in particular idioms, in the English language picture of the world are clarified. The values ​​of these lexical units are emphasized, as they not only reflect the spheres of society but also contribute to the enrichment of the individual with linguistic information, help to learn the language through the prism of modern living communication, imbued with such units of language. The manifestation of coordinate phrases in English idioms is traced and the peculiarity of their formal-grammatical and semantic-syntactic levels is investigated. After the analysis, the author concludes that the language has idioms in which coordinate phrases are homogeneous, i.e. both components belong to the same part of speech, mainly nouns, verbs and adjective phrases. Their primary meaning as free phrases is leveled in the idioms, so the latter belong to the phraseological fusions according to the well-known V. Vinogradov’s classification of phraseological units. It is noteworthy that there are cases of coordinate connection at the level of word combinations between functional words – prepositions. Not surprisingly, but such combinations have all the parameters by which they can be attributed to fixed coordinate phrases.
The principles of acmeistic poetics in the works of I. Bahrianyi
Authors:   State Institution Luhansk Taras Shevchenko National University, Kryzhanovska O. O.
Published: July 2022

The author of the article, Olha Kryzhanovska, found that acmeism develops not only in the works of poets of the early twentieth century, but also throughout the twentieth century and in the modern literary process. The history of the development of acmeism proves its productivity. Acmeism does not depend on chronology. Acmeism has changed over a hundred years of existence, this is not a literary direction, it is a creative method. The author of the article to study poetry, Ivan Bahrianyi, uses the concept of the Ukrainian researcher Tatyana Pakhareva. The author of the article determined that the dominant markers of acmeistic works are the synthesis of historicism, cultural centrism and ethicocentrism. The author of the article proved that these principles of acmeistic poetics are present in the poetry of Ivan Bahrianyi. The poems „Sandro Botticelli”, „Shakhtar”, „Malyar” have such acmeistic markers: historicism, cultural centrism and ethicocentrism. In the article, the author proved that the image of Sandro Botticelli is not monumental. The poet depicts the artist from Italy as a lonely man. The author of the poem helps the reader to see the connection with the Italian artist. Olha Kryzhanovska proved that in the poem „Shakhtar” Ivan Bahrianyi presents a different interpretation. The lyrical hero of the work has a large historical scale. It is a big world culture. In the poem “Malyar”, Ivan Bahrianyi compares the work of a painter with the work of great artists. The author of poems makes ordinary people who have working professions great personalities in history. Olha Kryzhanovska proved that in poetry Ivan Bahrianyi wrote a lot about the history and fate of man.Ivan Bahrianyi believed that the history of Ukraine and the fate of a citizen of Ukraine are connected. Olha Kryzhanovska proved that the poems that Ivan Bahrianyi wrote in exile represent the tragic experience of the poet. Ivan Bahrianyi wrote that every Ukrainian participates in the fate of Ukraine and is responsible for his homeland. Olha Kryzhanovska studied historicism, cultural centrism and ethicocentrism in the poetry of Ivan Bahrianyi. The author of the article proved that these principles of acmeism help to deeply understand the works of the Ukrainian poet Ivan Bahrianyi.
Diseño y validación de la escala de percepción del teletrabajo (Tele-Cov-19) en docentes de educación básica peruanos
Authors: Mamani-Benito Oscar Javier , Sucapuca Quispe Edwuin Javier , Yapu Jallo Luzby , Carranza Esteban Renzo Felipe , Turpo Chaparro Josué Edison , Lingan Susana K.
Published: July 2022

Introducción: Diseñar y validar una escala de percepción acerca del teletrabajo en docentes de educación básica peruanos.

Método: Estudio transversal, con 400 docentes de educación básica (61,50% mujeres) entre 21 y 61 años, de 6 ciudades del sur de Perú. Se propusieron 8 ítems que obedecen a los conceptos de capacitación, seguridad, flexibilidad de los horarios a partir de aspectos teóricos hallados en la literatura científica. La escala fue validada por 7 expertos que evaluaron relevancia, representatividad y claridad de los ítems. Posteriormente se aplicó el análisis factorial exploratorio (AFE) y el análisis factorial confirmatorio (AFC), mediante el programa FACTOR Analysis y el SPSS AMOS versión 21.

Resultados: Los indicadores V de Aiken fueron estadísticamente significativos para los 8 ítems. Previa ejecución del AFE se calculó el coeficiente KMO (0,93) y el test de Bartlett (1832,90; gl = 28; p = 0,00). Se evidenció la existencia de un solo factor que explica el 62,27 % de la varianza total de la escala y sus cargas factoriales oscilan entre 0,65 y 0,84. El AFC corroboró la estructura interna de la escala (χ2 = 58,24, df = 20, p < 0,01; RMR = 0,03; TLI = 0,97; CFI = 0,97; y RMSEA = 0,06) y la confiabilidad fue aceptable (α = 0,93; IC 95% = 0,89 – 0,92).

Conclusiones: La escala muestra evidencias de validez basada en el contenido, estructura interna y fiabilidad.
Propuesta de un índice que resume las medidas preventivas no farmacológicas adoptadas frente al SARS-CoV-2 en las empresas, el caso del Parc de Salut Mar (Barcelona)
Authors: Utzet Sadurni Mireia , Serra Consol , Ramada Jose María , Villar Rocío , De Travesedo Consuelo , Del Prado Julià , G. Benavides Fernando
Published: July 2022

Introducción: Construir un índice numérico con las medidas preventivas no farmacológicas frente a Sars-CoV-2 a partir de la experiencia del Parc de Salut Mar (PSMar), una institución sanitaria en Barcelona.

Método: La construcción del índice se ha realizado en tres fases. La identificación y selección de las variables incluidas a partir de entrevistas semiestructuradas a informantes clave y la revisión documental. La definición de las dimensiones (con una o más variables) y la operacionalización del índice (a partir de las dimensiones). Se ha estimado el índice en el PSMar, y en sus dos principales centros, el Hospital del Mar y el Hospital de la Esperanza.

Resultados: Se identificaron 21 variables, clasificadas en 6 dimensiones: equipos de protección individual, medidas organizativas individuales, medidas organizativas colectivas, medidas de vigilancia epidemiológica, actividades formativas, y elaboración de protocolos. Durante la primera ola, el índice en el Hospital del Mar se mantuvo por encima del valor obtenido en el Hospital de la Esperanza; en la segunda ola ambos índices presentaron valores similares hasta la semana 36, cuando el hospital del Mar comenzó a presentar valores superiores. Estas oscilaciones se debieron principalmente a los equipos de protección individual y actividades formativas.

Conclusiones: El índice propuesto muestra las dificultades para aplicar las medidas preventivas no farmacológicas en las primeras semanas de la pandemia. Esta herramienta puede ser útil para evaluar las actividades desarrolladas frente a la pandemia por parte de los Servicios de Prevención de Riesgos Laborales, con las oportunas adaptaciones a la realidad de cada empresa.
The Effect of Nasal Irrigation with Dewandaru (Eugenia Uniflora L) Leaves Ethanol Extract on Il-4 Levels, Thymic Stromal Lymphopoiethin (TSLP) Expression and Expression of H4 Mucosa Receptors of Wistar Rats with Allergic Rhinitis
Authors: Sutanegara Sari Wulan Dwi
Published: July 2022

Nasal irrigation with Dewandaru leaf extract can reduce inflammatory cell infiltration in the nasal mucosa of rats, and is effective in reducing RA symptoms and has an effect no different from topical corticosteroids. This study aims to prove whether nasal irrigation with ethanolic extract of Dewandaru leaves can reduce the infiltration of allergic inflammatory mediators in the nasal mucosa of male white rats of Wistar strain suffering from RA after ovalbumin nasal spray was induced, by assessing IL-4 levels, TSLP expression and H4 receptor expression. The study was conducted with a randomized post test only control group design, using an animal model of allergic rhinitis, involving 34 male white rats of the Wistar strain, divided into 2, namely: 17 treatment groups and 17 control groups. After 4 weeks of exposure, termination and sampling of rat nasal mucosa was performed. Statistical analysis using the independent sample T test showed that the levels of IL-4 in the nasal mucosa of rats and the expression of H4 receptors on the nasal mucosa of rats were significantly lower than in the control group (p<0.05). Meanwhile, the TSLP expression of the nasal mucosa of rats in the treatment group (2.0154) was not significantly different from the control group (2.1891) with p=0.478, possibly associated with less severe damage to the epithelial barrier cells of the nasal mucosa of TSLP-producing in the group control. The ethanolic extract of Dewandaru leaves has the ability to suppress IL-4 cytokine levels through inhibition of the activity of RH4, so it can be used as a supporting therapy for nasal irrigation that can suppress allergic inflammatory mediators in the nasal mucosa of rats.
A Usage History Information Generation and Inquiry Method for Theme, Background and Signal Music Based on Hyperledger Fabric
Authors: Kim Youngmo , Park Byeongchan , Kim Seok-Yoon
Published: July 2022

Theme, background and signal music is the music inserted into broadcasting contents of a broadcaster, and is recognized as a created content like normal music. Since there are lyricists and composers who have the rights of music, the copyright fee is distributed. However, there often occur problems with inaccurate monitoring results for theme, background and signal music usage due to the omission of usage details and non-transparent settlement method. In this paper, we propose a method of generating music usage monitoring information based on a blockchain, on which the usage information of music source is recorded by the usage monitoring tool based on the feature-based filtering technology of monitoring organizations. The framework proposed in this paper includes a blockchain network structure, a series of transaction procedures in which the theme, background and signal music usage history is stored and the recorded data format in the blockchain ledger. In the proposed framework, accurate music usage details can be created, details are stored in blocks without changes or omissions, and eventually transparent settlement and distribution are possible by processing smart contract, instead of previous non-transparent settlement practice.
Office intelligent lighting system based on the natural lighting and the ZigBee wireless network
Authors: Qin Xinjing , Wang Zhisheng , Zhang Yuncui , Zhang Manqun , Feng Yue
Published: July 2022

A comfortable and healthy lighting environment cannot only make people comfortable and improve work efficiency, but also avoid visual fatigue caused by the discomfortable lighting environment. In order to solve these problems, this paper proposes an intelligent lighting system that takes natural lighting and the occupancy situation as input and dimming factor

K

(

0

<
K
<

1

) as output. The linear function between illuminance of the working surface and natural lighting, the occupancy situation, illuminance components of adjacent luminaires, and dimming factor

K

is obtained through the control algorithm. The simplex method is one of the most commonly used and effective algorithms for solving linear programming problems, so the optimal dimming factor

K

of each luminaire is obtained. The intelligent lighting system uses the ZigBee tree network structure to transmit the dimming factor to each lamp, making the office lighting environment reach the target value. Opnet is used as a network simulation software to verify system information, such as delay, throughput, and load. The results show that the network transmission delay is only 0.011 s, and the load and throughput are both above

3.0

×

10

4

b
i
t
s

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. As an optical software, DIAlux simulates the lighting environment under the control system in two modes: day and night. The results show that the illuminance of the occupied working surface under the system reaches

500

l

×

, and the illuminance of the unoccupied working surface reaches

300

l

×

. The uniformity of illuminance is greater than 0.7. In the day mode, the uniformity of illuminance is improved compared to without any control system. Finally, the energy-saving efficiency of the control system reached 34% and 25% during the day and night, respectively.
Appetite regulating genes in zebrafish gut; a gene expression study
Authors: Ahi Ehsan Pashay , Brunel Mathilde , Tsakoumis Emmanouil , Chen Junyu , Schmitz Monika
Published: July 2022

The underlying molecular pathophysiology of feeding disorders, particularly in peripheral organs, is still largely unknown. A range of molecular factors encoded by appetite-regulating genes are already described to control feeding behaviour in the brain. However, the important role of the gastrointestinal tract in the regulation of appetite and feeding in connection to the brain has gained more attention in the recent years. An example of such inter-organ connection can be the signals mediated by leptin, a key regulator of body weight, food intake and metabolism, with conserved anorexigenic effects in vertebrates. Leptin signals functions through its receptor (lepr) in multiple organs, including the brain and the gastrointestinal tract. So far, the regulatory connections between leptin signal and other appetite-regulating genes remain unclear, particularly in the gastrointestinal system. In this study, we used a zebrafish mutant with impaired function of leptin receptor to explore gut expression patterns of appetite-regulating genes, under different feeding conditions (normal feeding, 7-day fasting, 2 and 6-hours refeeding). We provide evidence that most appetite-regulating genes are expressed in the zebrafish gut. On one hand, we did not observed significant differences in the expression of orexigenic genes (except for hcrt) after changes in the feeding condition. On the other hand, we found 8 anorexigenic genes in wild-types (cart2, cart3, dbi, oxt, nmu, nucb2a, pacap and pomc), as well as 4 genes in lepr mutants (cart3, kiss1, kiss1r and nucb2a), to be differentially expressed in the zebrafish gut after changes in feeding conditions. Most of these genes also showed significant differences in their expression between wild-type and lepr mutant. Finally, we observed that impaired leptin signalling influences potential regulatory connections between anorexigenic genes in zebrafish gut. Altogether, these transcriptional changes propose a potential role of leptin signal in the regulation of feeding through changes in expression of certain anorexigenic genes in the gastrointestinal tract of zebrafish.