bluuebunny/crossref_metadata_2025 huggingface dataset:
Deconstruction of Lignocellulose Biomass via Ultrasonic-assisted Extraction Facilitates the Release of Soluble Sugars
Authors: Ortekin Hazal , Yunusa Umar Muazu , Karapinar İlgi
Published: December 2024

The valorization of lignocellulosic biomass (LCB) into valuable products or energy sources stands as a promising strategy for achieving waste-to-wealth, circular economy goals, and carbon neutrality. Traditional techniques for extracting fermentable sugars from LCB are associated with high energy and time consumption, leading to increased costs. Ultrasonic-assisted extraction (UAE) offers a sustainable alternative, requiring a moderate investment of time and energy. UAE operates on the principle that subjecting a biomass suspension to high-intensity ultrasound induces acoustic cavitation, a phenomenon capable of lignin deconstruction and facilitating the release of soluble sugars. This study aims to explore the impact of UAE on fermentable sugar yield and supernatant recovery from apple pomace waste. The Box-Behnken Statistical Experimental Design model was employed for the optimization of process parameters, with particle diameter (Dp = 90 – 181 μm), time (t = 2 – 8 min), and power (P = 60 – 100%) as independent variables. Dependent variables were total sugar content (TSC) and supernatant recovery. The fit statistics for the TSC response model were as follows: R² = 0.9481, adjusted R² = 0.8962, and predicted R² = 0.7068. Similarly, the fit sta-tistics for the supernatant recovery response model were R² = 0.9847, adjusted R² = 0.9642, and pre-dicted R² = 0.814. Optimum conditions for maximum TSC (25.91±1.22 g/L) with a corresponding supernatant recovery of 55% were determined as Dp = 181 μm, t = 6.5 min, and P = 90%. Validation experiments using point prediction demonstrated good agreement between model predictions and observed responses. The findings of this study suggest UAE as a sustainable approach for obtaining fermentable sugar from organic waste.
Design and Analysis of Series Resonant Converter
Authors: Abatcha Mahamat Chetima
Published: December 2024

Uninterruptible Power Supplies (UPS), which come into play during electricity outages, provide electrical power from an alternative source when grid power is cut off. Batteries, one of the funda-mental components of UPS, are pre-charged with grid energy.
In this project, a series resonance converter was used as the power converter. Using the funda-mental harmonic approach, methods for determining converter parameters are explained. As a result of the analysis, a series resonance power converter design was carried out for the operating values determined and simulations were made in a computer program with the obtained parameters.
In the study, STM32G474 microcontroller and its special high-resolution timers were used in the control part. The digital control of the circuit was coded using C language. PI method was preferred to obtain constant output voltage. Additionally, various input voltages and load conditions of the circuit were taken into account, and then tests were conducted to evaluate how it Works
Egg Quality Traits of French Pekin Ducks Reared Under the Indoor Housing Systems
Authors: Abdallah Nasir , Kursun Kadriye , Baylan Mikail
Published: December 2024

A total of 17 eggs of French Pekin ducks reared indoors under standard environmental conditions (20-220C and 55-60% RH) on a private duck breeding farm were used in the current study. The eggs were assessed for their internal and external egg quality traits using the destructive method. The average egg weight, egg width and egg height were 90.25±1.51g, 48.26±0.29 mm, and 69.10±0.68 mm respectively. The egg breaking strength or resistance, shape index, eggshell thickness and shell weight were 2.99±0.39 kg/cm2, 69.93±0.72%, 414.76±5. 99 mm and 8.28±0.15 g respectively. The shell percentage and elongation values were 9.19±0.15% and 1.43±0.01 respectively.
The average yolk height, yolk width and yolk weight were 21.35±0.23 mm, 50.79±0.53 mm and 35.02±0.98 g respectively. The L (brightness), a (redness) and b (yellowness) yolk color traits were 55.67±0.46, 13.06±0.37 and 55.60±0.88 respectively. The yolk index and yolk percentage were 42.07±0.49% and 38.85±0.96% respectively.
The albumen height, albumen width and albumen length were 8.16±0.23 mm, 67.91±1.21 mm and 106.26±1.63 mm respectively. The albumen pH, albumen weight and albumen index were 9.30±0.11, 42.01±0.88g and 9.39±0.30% respectively. The albumen percentage and yolk to albumen ratio were 46.67±1.02% and 84.03±3.14% respectively. The Haugh unit was 82.43±1.51%.
It was concluded the internal and external egg quality traits of the French Pekin ducks observed in this study were within the normal range.
Approximate Analytic Solutions of Forced Oscillations of Systems with Fractional Damping Affected by Quadratic Nonlinearity
Authors: Gümüş Şenol , Sınır Sümeyye , Yıldız Bengi
Published: December 2024

In this study, the two frequency excitation oscillations of system having quadratic nonlinearities with fractional damping is considered via Riemann-Liouville fractional derivative. The system is assumed under the effect of external harmonic force. The approximated first-order uniform expansion of the dynamic response is derived for nonlinear forced oscillations of systems by employing a perturbation technique; that is, the method of multiple scales. The damping term is also assumed in a linear form. Perturbation is a well-known technique gives approximate analytical solutions [1-3]. It is frequently preferred for equations that cannot be found analytically solutions, such as equations involving nonlinearity and fractional derivatives.In this research, perturbed solutions are examined for the system. The effects of the coefficient of a fractional damping term on the approximate solution are observed by graphs.
Determination of Stormwater Drainage in University Campuses; Case Study of İzmir Katip Çelebi University Campus
Authors: Gündel Hande , Kalaycı Önaç Ayşe
Published: December 2024

Structural development grows rapidly with urbanization, resulting in more and more impervious areas and therefore stormwater cannot infiltrate underground. In recent years, stormwater management models have been developed to solve the problem. The models have been the subject of natural-based solutions for the last decade. The principle of stormwater management aims to control stormwater in urban areas. The systems aim to replace the traditional sewage system with blue-green infrastructure systems which consist of rainwater harvesting, rain gardens, vegetated swales, green roofs, green walls, permeable pavement, and rainwater tanks. The method transforms an impermeable surface of asphalt, brick, concrete, and stone into permeable design tools. Flooding, one of the main consequences of climate change, is the biggest challenge for cities. Therefore, areas with high building density need to be transformed and especially rainwater needs to be used efficiently. This study aims to develop a management model for the efficient use of stormwater in university campuses, which are an important spatial part of cities. In this context, firstly, areas with high drainage density were identified with the ArcGIS 10.4 program and then an effective drainage network was created within the campus using the Stormwater Management Model (SWMM). The campus-wide system can also be applied and easily adapted to the city. With this method, the ratio of permeable areas is increased and new design models are created in urban areas.
Development of EGFR Targeting Peptide/Chlorin e6 Conjugates for Targeted Antitumor Activity on Breast Cancer
Authors: Idrees Mariam , Bilgiç Eda , Pulat Günnur , Avşar Nermin Topaloğlu
Published: December 2024

Breast cancer is considered the primary cause of cancer-related deaths in women. Conventionally, different treatment strategies such as hormone therapy, radiation therapy, surgical operations and chemotherapy are utilized in the treatment of breast cancer. Although, chemotherapy aims to kill cancerous cells by interfering with DNA synthesis and cell divisions leads to damage to healthy tissues as well as tumor tissues. Considering the side effects of the conventional treatments, developing novel alternative methods is crucial for breast cancer treatment. Photodynamic therapy (PDT) has emerged as a promising new approach due to its suitability for localized treatments. Chlorin e6 (Ce6), a porphyrin-derived photosensitizer that is frequently preferred in PDT applications, accumulates effectively on tumors. However, the anti-tumor effect of Ce6 is frequently restricted due to its poor targeting of cancer cells and toxicity to the healthy cells. Therefore, the combination of Ce6 with a tumor cell-specific agent may prevent the damage to healthy tissues by ensuring targeted application. GE11 peptide, a breast cancer targeting peptide, binds to epidermal growth factor receptor (EGFR) that is overexpressed in epithelial originated tumors including breast cancer. In this study, novel GE11-Ce6 conjugates that are able to specifically target breast cancer were synthesized and characterization of GE11-Ce6 conjugates was carried out by examining the FT-IR spectrum. Confocal fluorescence microscopy images demonstrated the cellular uptake of GE11-Ce6 conjugates into MDA-MB-231 tumor cells. Confocal images confirmed the enhanced accumulation of Ce6 into breast cancer cells with Ge11-Ce6 conjugates compared to Ce6 alone. Developed novel GE11-Ce6 conjugates have the potential to be an ideal breast cancer targeting antitumor agent.
A gamificação no ensino de ciências biológicas: sistemática nos anos finais do ensino fundamental
Authors: Queiroga Marcos Penha , Pacheco Clecia Simone Gonçalves Rosa
Published: December 2024

O objetivo do estudo foi analisar como a gamificação pode melhorar o engajamento, a compreensão e o desempenho dos alunos. Nesse sentido, buscou-se responder a seguinte pergunta norteadora: de que forma a gamificação pode ser implementada para melhorar o ensino de disciplinas consideradas complicadas pelos alunos, como a de ciências biológicas? Foi realizada uma pesquisa qualitativa voltada a revisão sistemática, para formação da base de dados documental sendo utilizados estudos encontrados em plataformas de divulgação científica, como: SciELO, Capes e o Google Acadêmico, selecionando-os por meio dos seguintes descritores:  gamificação e ciências; gamificação e ensino de ciências biológicas, e a gamificação do ensino. Ademais, através da pesquisa foi possível constatar que embora os professores tenham algum conhecimento sobre gamificação e afirmarem ser positivo enquanto metodologia, existe uma percepção equivocada a cerca de tal. A falta de uma abordagem positiva nos currículos de formação de professores e a ausência deste tema na formação continuada indicam um déficit na formação de professores, tanto na inicial quanto na continuada, o que impacta nas práticas educacionais, incluindo métodos como a gamificação na sala de aula. Em virtude disso, ficou claro que os alunos têm dificuldade em compreender conteúdos abstratos e, por isso, muitos acreditam que a gamificação pode melhorar o processo de ensino e aprendizagem de conteúdos abstratos da disciplina de ciências.
Suradnja Hede Festini s Institutom za filozofiju i časopisom Prilozi za istraživanje hrvatske filozofske baštine
Authors: Boršić Luka , Skuhala Karasman Ivana
Published: December 2024

U članku obrađujemo suradnju Hede Festini s Institutom za filozofiju i njegovim časopisom Prilozi za istraživanje hrvatske filozofske baštine, koji je pokrenut 1975. godine i u kojem je objavila dvadeset i četiri članka te jedan prikaz knjige. Detaljnije su obrađena tri teksta o dvoje hrvatskih filozofa dvadesetog stoljeća, Vladimiru Filipoviću i Mariji Bridi, koje je Festini dobro poznavala i s kojima je dugi niz godina surađivala.
VERMICULITE ENRICHED WITH EXTRACT FROM PROCESSED FOREST PRODUCTS, IN FEEDING CALVES
Authors: Tereschenko V. , Ivanov E. , Lyubimova Yu.
Published: December 2024

The article presents the results of studies on the use of expanded vermiculite, enriched with an extract from forest products, in feeding calves. The studies were conducted on two groups of analogue calves (control and experimental) with different feeding conditions: the control group received the main diet; experimental - in addition to the main diet, she received a dried mixture (20 g/animal/day), consisting of expanded vermiculite enriched with an aqueous extract of pine flour, pine nut shells and arabinogalactan. In the experiment, the growth and metabolic parameters of calves were studied. As a result, it was found that the inclusion of the tested mineral-vegetable feed additive in the diet of calves had a positive effect on their growth intensity and metabolic rates in the body, making it possible to increase the average daily gain in live weight of animals by 5.34%, the absolute increase – by 5.47%, relative increase – by 1.97 percentage points, increase the content of calcium in the blood by 3.67%, albumin – by 8.84%, total protein – by 10.25%.
THE INFLUENCE OF TECHNOLOGY ELEMENTS ON THE PRODUCTIVITY OF SPRING WHEAT VARIETIES
Authors: Romanov V. , Bobrovskiy A. , Kozulina N. , Vasilenko A. , Kryuchkov A.
Published: December 2024

The article presents the results of research on the influence of individual elements of technology on the productivity of spring wheat varieties of Siberian breeding. The maximum yield values were obtained at a seeding rate of 4.5 million. germinating grains / ha: in the Novosibirsk variety 15 – 3.72 t / ha, in the Krasnoyarsk variety 12 – 3.79 t /ha.
APPLICATION OF THE COMPUTER PROGRAM “ANALYSIS OF IMMUNOGENETIC DATA OF CATTLE” IN ANIMAL BREEDING
Authors: Efimova L.
Published: December 2024

The article provides information on computer programs that are intended to evaluate sires by the quality of their offspring using the "daughter-peer" method, analyze immunogenetic data of cattle, and biometrically process digital data obtained during research. The programs are intended for researchers, postgraduates, master's students, and students.
SPECIAL FEATURES OF THE SADON VARIETY REACTION ON MICROPROPAGATION CONDITIONS
Authors: Stupko V. , Lugovcova S.
Published: December 2024

For the first time, the reaction of the culture of single-node cuttings of the Sadon variety to the conditions of replication on artificial nutrient media in vitro was assessed. The ineffectiveness of previously successfully used approaches to increasing the efficiency of micropropagation in relation to this variety is shown.
BREEDING WORK OF FORAGE CROPS RESISTANT TO VARIOUS FACTORS IN THE CONDITIONS OF UZBEKISTAN
Authors: Allashov B. , Zhamolov S. , Bonni M.
Published: December 2024

The article presents information on the results of selection and seed production of forage crops such as sorghum (sorghum), oats (Avena sativa) in the conditions of the foothill zones of Uzbekistan. As a result of many years of scientific research, new lines of sorghum were created and obtained with an average height of the main stem of 229.4 ± 1.3 cm, a new line of oats - 161.0 ± 0.9 cm. The data obtained indicate good feeding qualities of the new lines of sorghum and oats.
STATE AND ANALYSIS OF THE WOOL MARKET IN THE RUSSIAN FEDERATION
Authors: Ageykin A. , Nagibina A. , Udalova T.
Published: December 2024

The article provides an overview of the current state of wool production in the Russian Federation. A comparative assessment of the state of the dynamics of sheep breeding in our country over the past twenty years is given. The current production and economic features in the structure of wool production in the country are described, both in farms of different forms of ownership and in federal districts.
CHARACTERISTICS OF BONE TISSUE IN RAMS OBTAINED FROM EVEWS WITH DIFFERENT MILK PRODUCTIVITY
Authors: Zabelina M. , Amiyan A.
Published: December 2024

The article presents data obtained in the process of studying the characteristics of bone tissue development in rams of the Edilbaev breed, obtained from ewes with different milk production. In particular, studies were carried out on the metacarpal bone. Our research results indicate intergroup differences in the nature of growth and development of bone tissue. It was found that in all studied parameters, with the exception of length, rams of the first group at both 4 and 7 months of age were superior to rams of the second and third groups at the same ages.
EVALUATION OF THE USE OF VARIOUS BROILER’S CROSSES
Authors: Izmaylovich I. , Avsievich M.
Published: December 2024

The main link in the chain of tasks to increase poultry production is the use of competitive crosses of broiler chickens.
The technology for raising broiler chickens of various crosses is constantly evolving. Today crosses are being developed and continue to be improved.
Taking into account new technologies, the goal of our research was to study the effectiveness of raising broiler chickens of various crosses.
During the scientific experiment, the dynamics of the live weight of experimental broilers, the safety of the livestock were analyzed, and the cost of feed for the increase in live weight was calculated.
It has been established that broiler chickens of the KOBB-500 and ROSS-308 crosses are quite competitive, and nevertheless, the ROSS-308 cross was more effective both in live weight and in terms of feed costs for live weight gain.
PRODUCTIVITY OF GOATS WITH DIFFERENT HORN SHAPE
Authors: Kargachakova T. , Chikalev A.
Published: December 2024

The productivity of Altai white downy goats with horns of the prisca type and the bezoar goat was established. It has been established that goats with horns of the prisca type are superior to goats with horns of the bezoar type in terms of down length by 5.6-7.8%, in fleece of down by 9.5%, and their down is coarser by 20.7%. In terms of live weight, the differences between goats with different horn shapes are 0.6-0.9%.
THE CURRENT STATE OF MARAL BREEDING
Authors: Kombu A. , Bayan-ool N.
Published: December 2024

The article analyzes the maral breeding activity from 2019 to 2023 by comparing the indicators of the number of maral livestock, their productivity, and the volume of production of the industry. The current state of the maral breeding farm "Turan" has been studied, the main problems and prospects of its development have been analyzed.
CHEMICAL COMPOSITION OF YOUNG HORSE MEAT UNDER THE CONDITIONS OF DIFFERENT ZONES OF THE REPUBLIC OF TYVA
Authors: Mongush S. , Tumat I.
Published: December 2024

The article presents the results of scientific research on the chemical composition of the meat of young horses bred in different climatic zones of the Republic of Tyva.
WHY IS THE VALUE ADDED INDICATOR NOT USED TO ASSESS THE EFFICIENCY OF AGRICULTURAL PRODUCTION?
Authors: Tabakov N.
Published: December 2024

Recently, opinions have been increasingly voiced that the import substitution company did not have an effect, did not lead to economic growth and did not allow domestic technologies equivalent to foreign ones to appear. Analyzing the state of food security, the question arises: why have we forgotten about value added as an indicator of the effective processing of agricultural raw materials produced. This problem is more significant than import substitution, and its solution is vital. You need to turn your grain into flour and sell it at significantly higher prices.
CONJUGATE VARIABILITY OF ECONOMICALLY USEFUL SIGNS OF CATTLE
Authors: Chalova N.
Published: December 2024

Correlations between economically useful parameters of Holstein cattle (Russian breeding) are considered. When selecting the first heifers by milk yield, it is possible to predict an increase in the absolute yield of fat and protein and an increase in the duration of the period from calving to fruitful insemination. The selection of cows by fat content simultaneously leads to an increase in protein levels in milk. Animal breeding by live weight is ineffective in farming conditions.
ANTIBIOTIC RESISTANCE OF L. MONOCYTOGENES AFTER EXPOSURE TO INFRARED RADIATION
Authors: Volkova T. , Shkil' N.
Published: December 2024

The article presents the results of the influence of infrared radiation on Listeria monocytogenes in products of animal origin, and results of the sensitivity of the microorganism to antibacterial drugs are obtained.
THE INFLUENCE OF COMPLEX THERAPY ON THE BODY OF CATTLE WITH COMBINED INVASIONS
Authors: Klimenkova I. , Spiridonova N.
Published: December 2024

The dynamics of the content of vitamins A, C, E, B1 and B2 in whole blood and its serum was determined in cattle suffering from fascioliasis and strongylatosis of the gastrointestinal tract, as well as as a result of treatment with an anthelmintic drug in combination with vitamins. The obtained indicators will complement the information on vitamin metabolism in this type of animal under normal conditions and with parasitic diseases, which also serve as a basis for adjusting therapeutic and preventive measures for combined infestations.
ECONOMIC EFFECT OF THE ENDOMETRITIS PREVENTION SCHEME IN COWS
Authors: Chekunkova Yu. , Ashenbrenner A. , Haperskiy Yu. , Belyaeva N.
Published: December 2024

The article considers an algorithm for calculating the economic effect on the ruble of the cost of schemes for the prevention of acute endometritis of cows by comparing the basic protocol with the new one. The use of the complex biogenic drug developed by us in the scheme of prevention of acute postpartum endometritis is economically beneficial, since the economic effect per 1 ruble of costs per head per day is 74.19 rubles, to the protocol of the farm – 18.55 rubles.
ABOUT PROCESSING OF SHEEPSKIN AND FUR RAW MATERIALS USING TUVAN TRADITIONAL
Authors: Dazhy Ch.
Published: December 2024

For many years, Tuvan cattle breeders have been developing the simplest and most expedient forms of processing livestock products, many of which were unique, inherent only to Tuvinians.
QUALITY CONTROL OF SOFT CHEESE WITH BERRY COMPONENT
Authors: Druzhechkova E. , Velichko N.
Published: December 2024

The possibility of using sea buckthorn juice in the production of soft cheeses is considered. A methodology has been developed for quality control of raw materials and the finished product with the addition of a berry component at all stages of its preparation.
ECONOMIC EFFICIENCY OF USING SERVICEBERIES IN THE PRODUCTION OF PASTILE PRODUCTS
Authors: Mel'nikova E.
Published: December 2024

The paper presents the economic efficiency of using regional berry raw materials in the production of sugary confectionery products, using the example of the common serviceberry (Amelanchier Medik). The chemical composition and growth area are considered. A comparative calculation of the cost and profitability of the production of pastille products based on puree from serviceberry berries is presented.
ONTOLOGICAL STATUS OF THE SYMBOL IN A.F. LOSEV'S AESTHETICS
Authors: STASKEVICH S.
Published: December 2024

The aim of the article is to reveal the role of the symbol and A.F. Losev's ontological scheme in the sphere of art.
The article attempts to link the ideas of two important works of A.F. Losev: “Philosophy of the Name” and “Dialectics
of Artistic Form” within the framework of a single theoretical construction. The concepts that influenced the formation
of A.F. Losev's ontological scheme and his aesthetic views are analyzed. The significance of the symbol in the artistic
sphere at each stage of A.F. Losev's ontological scheme, as well as its role in the creation of artistic form is revealed.
THE RELATIONSHIP BETWEEN THE LEVEL OF EMPATHY OF VOLUNTEER STUDENTS AND VOLUNTEER ACTIVITY
Authors: ZHUKOVA T. , YANKOVSKAYA M.
Published: December 2024

The article considers empathy as a property of a person's personality that contributes to understanding the inner
world of another person, familiarization with his life, as well as the implementation of helping behavior in situations
of communication and interaction. The authors study empathy in the aggregate of emotional, cognitive and behavioral
components, the peculiarities of its manifestation in volunteer activity and the relationship with the activity of student
volunteers. Volunteer students studying at different faculties and specialties, in the process of public charity work,
improve their communication skills, teamwork skills, develop the ability to listen to another, paraphrase, reflect and
mirror emotions, form “soft skills” or “flexible skills” (which include empathy) necessary for successful.
Correlation between gut microbiota and tumor immune microenvironment: A bibliometric and visualized study
Authors: Hu Zheng-Jun , Zhu Hui-Rong , Jin Yong-Jie , Liu Pan , Yu Xiao-Wei , Zhang Yu-Ren
Published: December 2024

BACKGROUND

In recent years, numerous reports have been published regarding the relationship between the gut microbiota and the tumor immune microenvironment (TIME). However, to date, no systematic study has been conducted on the relationship between gut microbiota and the TIME using bibliometric methods.

AIM

To describe the current global research status on the correlation between gut microbiota and the TIME, and to identify the most influential countries, research institutions, researchers, and research hotspots related to this topic.

METHODS

We searched for all literature related to gut microbiota and TIME published from January 1, 2014, to May 28, 2024, in the Web of Science Core Collection database. We then conducted a bibliometric analysis and created visual maps of the published literature on countries, institutions, authors, keywords, references, etc., using CiteSpace (6.2R6), VOSviewer (1.6.20), and bibliometrics (based on R 4.3.2).

RESULTS

In total, 491 documents were included, with a rapid increase in the number of publications starting in 2019. The country with the highest number of publications was China, followed by the United States. Germany has the highest number of citations in literature. From a centrality perspective, the United States has the highest influence in this field. The institutions with the highest number of publications were Shanghai Jiao Tong University and Zhejiang University. However, the institution with the most citations was the United States National Cancer Institute. Among authors, Professor Giorgio Trinchieri from the National Institutes of Health has the most local impact in this field. The most cited author was Fan XZ. The results of journal publications showed that the top three journals with the highest number of published papers were Frontiers in Immunology, Cancers, and Frontiers in Oncology. The three most frequently used keywords were gut microbiota, tumor microenvironment, and immunotherapy.

CONCLUSION

This study systematically elaborates on the research progress related to gut microbiota and TIME over the past decade. Research results indicate that the number of publications has rapidly increased since 2019, with research hotspots including “gut microbiota”, “tumor microenvironment” and “immunotherapy”. Exploring the effects of specific gut microbiota or derived metabolites on the behavior of immune cells in the TIME, regulating the secretion of immune molecules, and influencing immunotherapy are research hotspots and future research directions.
Pancreatic cancer: Future challenges and new perspectives for an early diagnosis
Authors: Cocca Silvia , Pontillo Giuseppina , Lupo Marinella , Lieto Raffaele , Marocchi Margherita , Marsico Maria , Dell'Aquila Emanuela , Mangiafico Santi , Grande Giuseppe , Conigliaro Rita , Bertani Helga
Published: December 2024

This editorial is a commentary on the case report by Furuya et al focusing on the challenging diagnosis of early pancreatic adenocarcinoma and new tools for an earlier diagnosis. Currently, pancreatic cancer still has a poor prognosis, mainly due to late diagnosis in an advanced stage. Two main precancerous routes have been identified as pathways to pancreatic adenocarcinoma: The first encompasses a large group of mucinous cystic lesions: intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, and the second is pancreatic intraepithelial neoplasia. In the last decade the focus of research has been to identify high-risk patients, using advanced imaging techniques (magnetic resonance cholangiopancreatography or endoscopic ultrasonography) which could be helpful in finding “indirect signs” of early stage pancreatic lesions. Nevertheless, the survival rate still remains poor, and alternative screening methods are under investigation. Endoscopic retrograde cholangiopancreatography followed by serial pancreatic juice aspiration cytology could be a promising tool for identifying precursor lesions such as intraductal papillary mucinous neoplasm, but confirming data are still needed to validate its role. Probably a combination of cross-sectional imaging, endoscopic techniques (old and new ones) and genetic and biological biomarkers (also in pancreatic juice) could be the best solution to reach an early diagnosis. Biomarkers could help to predict and follow the progression of early pancreatic lesions. However, further studies are needed to validate their diagnostic reliability and to establish diagnostic algorithms to improve prognosis and survival in patients with pancreatic cancer.
Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma
Authors: Zhou Shi-Qiong , Wan Peng , Zhang Seng , Ren Yuan , Li Hong-Tao , Ke Qing-Hua
Published: December 2024

BACKGROUND

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis. When it metastasizes to the liver, treatment options become particularly limited and challenging. Current treatment options for liver metastatic PDAC are limited, and chemotherapy alone often proves insufficient. Immunotherapy, particularly programmed cell death 1 (PD-1) inhibitors like sintilimab, shows potential efficacy for various cancers but has limited reports on PDAC. This study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic PDAC.

AIM

To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine (combination group) vs S-1 and gemcitabine used alone (chemotherapy group) for treating liver metastatic pancreatic adenocarcinoma.

METHODS

Eligible patients were those with only liver metastatic PDAC, an Eastern Cooperative Oncology Group performance status of 0-1, adequate organ and marrow functions, and no prior anticancer therapy. Participants in the combination group received intravenous sintilimab 200 mg every 3 weeks, oral S-1 40 mg/m² twice daily on days 1-14 of a 21-day cycle, and intravenous gemcitabine 1000 mg/m² on days 1 and 8 of the same cycle for up to eight cycles or until disease progression, death, or unacceptable toxicity. Participants in the chemotherapy group received oral S-1 40 mg/m² twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m² on days 1 and 8 of the same cycle for up to eight cycles. Between June 2020 and December 2021, 66 participants were enrolled, with 32 receiving the combination treatment and 34 receiving chemotherapy alone.

RESULTS

The group receiving the combined therapy exhibited a markedly prolonged median overall survival (18.8 months compared to 10.3 months, P < 0.05) and progression-free survival (9.6 months vs 5.4 months, P < 0.05). compared to the chemotherapy group. The incidence of severe adverse events did not differ significantly between the two groups (P > 0.05).

CONCLUSION

The combination of PD-1 inhibitor sintilimab with S-1 and gemcitabine demonstrated effectiveness and safety for treating liver metastatic PDAC, meriting further investigation.
Turning the tide: From cervical cancer's grip to complete response: A case report
Authors: Abutaha Shatha , Alzibdeh Abdulla , Mohamad Issa , Wahbeh Lina , Salah Samer , Abuhijlih Ramiz , Abuhijla Fawzi
Published: December 2024

BACKGROUND

Cervical cancer is a formidable global health issue, particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines, screening programs, and treatment modalities. The case report presents a unique case of a large cervical cancer achieving complete response (CR) with concurrent chemoradiotherapy (CCRT), highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy (RT) in optimizing patient outcomes.

CASE SUMMARY

We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive, moderately differentiated cervical squamous cell carcinoma. The tumor measured 14 cm × 12 cm × 8 cm, the largest size reported in the literature to achieve CR with CCRT. Despite this monumental feat, the patient remained disease-free and is currently on follow-up for 2 years; however, she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis, underscoring the continuing impact of cervical cancer on quality of life.

CONCLUSION

In this case report, we highlight the effectiveness of CCRT in achieving CR, even in cases of bulky cervical cancer, with adaptive RT offering a customized strategy to improve patient outcomes. We also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.
Combined BRAF G469A mutation and echinoderm microtubule associated protein like-4-anaplastic lymphoma kinase rearrangement with resistance: A case report and review of literature
Authors: Guo Xuan , Liu Yan , Wang Yu-Ting , Liu Kan , Ding Hui
Published: December 2024

BACKGROUND

Through deeper understanding of targetable driver mutations in non-small-cell lung cancer (NSCLC) over the past years, some patients with driver mutations have benefited from the targeted molecular therapies. Although the anaplastic lymphoma kinase and BRAF mutations are not frequent subtypes in NSCLC, the availability of several targeted-drugs has been confirmed through a series of clinical trials. But little is clear about the proper strategy in rare BRAF G469A mutation, not to mention co-exhibition of anaplastic lymphoma kinase and BRAF G469A mutations, which is extremely rare in NSCLC.

CASE SUMMARY

We present a patient to stage IVA lung adenocarcinoma with coexisting echinoderm microtubule associated protein like-4 rearrangement and BRAF G469A mutation. She received several targeted drugs with unintended resistance and suffered from unbearable adverse events.

CONCLUSION

Due to the rarity of co-mutations, the case not only enriches the limited literature on NSCLC harbouring BRAF G469A and echinoderm microtubule associated protein like-4 mutations, but also suggests the efficacy and safety of specific multiple-drug therapy in such patients.
Discovery of primary lung cancer following resection of rectal cancer lung metastasis: A case report
Authors: Zhou Fei-Yan , Song Fang-Hua , Cheng Zhen-Hao , Wu Sen
Published: December 2024

BACKGROUND

Colorectal cancer (CRC) ranks high among the most common types of malignant tumors. The primary cause of cancer-related mortality is metastasis, with lung metastases accounting for 32.9% of all cases of metastatic CRC (MCRC). However, cases of MCRC in the lungs, which present concurrently with primary peripheral lung adenocarcinoma, are exceptionally rare.

CASE SUMMARY

This report describes the case of a 52-year-old female patient who, following a colonoscopy, was diagnosed with moderately differentiated adenocarcinoma based on rectal mucosal biopsy findings. A preoperative chest computed tomography scan revealed a ground-glass nodule in the right lung and a small nodule (approximately 0.6 cm in diameter) in the extramural basal segment of the left lower lobe, which suggested multiple lung metastases from rectal cancer. Subsequent treatment and follow-up led to a diagnosis of rectal cancer with left lung metastasis and peripheral adenocarcinoma of the lower lobe of the right lung.

CONCLUSION

This case report describes the therapeutic journey of a patient with lung metastasis from rectal cancer in addition to primary peripheral adenocarcinoma, thus underscoring the critical roles of multidisciplinary collaboration, personalized treatment strategies, and comprehensive patient rehabilitation guidance.
Spadek znaczenia renty gruntowej w długim okresie i jego konsekwencje
Authors: Czyżewski Bazyli , Staniszewski Jakub
Published: December 2024

Opracowanie rozwija tezę Thomasa Picketty’ego, wydzielając z ogólnych zasobów kapitału zasoby ziemi, a następnie dokonując porównania tempa wzrostu rent z ziemi z tempem wzrostu dochodów z pozostałych czynników produkcji. Na podstawie badania długookresowych trendów we Włoszech, w Hiszpanii, Wielkiej Brytanii, Niemczech, we Francji, w Danii i Polsce zidentyfikowano powszechne dla większości tych państw zjawisko regresu renty gruntowej, które niesie szereg negatywnych konsekwencji, takich jak land-grabbing, niezrównoważenie procesów wytwórczych w rolnictwie czy relatywne pogorszenie sytuacji rolników. Występowanie tych zjawisk, związane z uwarunkowanym działaniami mechanizmu rynkowego, regresem renty gruntowej, wskazuje na potrzebę korekty działania tegoż mechanizmu narzędziami polityki rolnej.
Zróżnicowanie społeczne „wiejskiej Europy”
Authors: Halamska Maria
Published: December 2024

Na podstawie bazy danych badania European Social Survey z 2010 roku autorka przedstawia zróżnicowanie społeczne ludności wiejskiej 21 krajów Unii Europejskiej. W szkicu stara się odpowiedzieć na następujące pytania: na ile specyficzne w stosunku do całego kraju są wiejskie populacje, tzn. czy odmienna jest ich struktura demograficzna, źródła utrzymania, wykształcenie i struktura społeczno-zawodowa; jak duże są te odmienności, czy można wyróżnić pewne typy społecznej struktury wsi w Europie. Są one ukazane na tle stopnia ruralizacji, poziomu rozwoju społeczno-ekonomicznego oraz zróżnicowania dochodów w badanych krajach. Autorka konkluduje, że „wiejska Europa” jest bardziej zróżnicowana niż całe europejskie społeczeństwa, ludność wiejska jest nieco starsza i słabiej wykształcona. Dominującą grupą społeczną na europejskiej wsi są robotnicy, natomiast rolnicy prawie wszędzie grupą najmniej liczną.
Skutki energetycznego wykorzystania biomasy
Authors: Banaszuk Piotr , Wysocka-Czubaszek Agnieszka , Czubaszek Robert , Roj-Rojewski Sławomir
Published: December 2024

Duży potencjał energetyczny biomasy stwarza szansę dla ochrony klimatu pod warunkiem jej racjonalnego wykorzystania. Niewłaściwe wytwarzanie biomasy może mieć negatywny wpływ na przyrodę i klimat. Wprowadzanie monokultur roślin energetycznych, zwłaszcza uprawianych bez prawidłowo prowadzonych zabiegów uprawowych oraz przy nadmiernym nawożeniu, może prowadzić do zwiększenia erozji wodnej i wietrznej, a także do zanieczyszczenia wód gruntowych i powierzchniowych. Zwiększanie powierzchni monokultur roślin energetycznych zaczyna wpływać negatywnie na kulturowy krajobraz wiejski. Kolejnym problemem jest wprowadzanie upraw energetycznych na cenne, z punktu widzenia bioróżnorodności, ekstensywnie użytkowane łąki i pastwiska „marginalne”. Zwiększenie produkcji biomasy energetycznej może być ważnym elementem wielofunkcyjnego rozwoju wsi i mieć korzystny wpływ na dochody rolników, jednakże jej produkcja może też stanowić konkurencję dla innych upraw, czego efektem będzie podwyżka cen żywności. Dlatego wykorzystanie biomasy na cele energetyczne powinno być poprzedzone wnikliwą analizą skutków środowiskowych, społecznych i ekonomicznych, jakie niesie ze sobą uzyskiwanie energii odnawialnej z tego źródła. Surowce energetyczne pochodzenia rolniczego powinny być wytwarzane w warunkach oszczędnego gospodarowania zasobami, a ich produkcja nie może stanowić zagrożenia dla środowiska. Energetyczne wykorzystanie biomasy powinno w pierwszej kolejności wiązać się z zagospodarowaniem odpadów z produkcji rolnej, biomasy z pielęgnacji ekosystemów chronionych i nadwyżkowej biomasy z leśnictwa.
Recenzja książki Krystyny Romaniszyn: Krótki wykład o utowarowieniu
Authors: Wieruszewska Maria
Published: December 2024

Wydawnictwo Uniwersytetu Jagiellońskiego, Kraków 2015, stron 156.
Socjolog wobec młodych biednych na wsi. Recenzja książki Piotra Bindera: Młodzi a bieda. Strategie radzenia sobie w doświadczeniu młodego pokolenia wsi pokołchozowych i popegeerowskich
Authors: Bukraba-Rylska Izabella
Published: December 2024

IFiS PAN, Warszawa 2014, stron 336.
Evaluación del riesgo de inundación y planificación territorial en el cantón de playas
Authors: Cedeño Alexandra
Published: December 2024

El cantón General Villamil Playas sufre cada año inundaciones en algunas colonias y proporciones, en algunos lugares, sobre todo en asentamientos informales y sitios de alto riesgo. Con el paso de los años, se incrementa con cada temporada invernal en lugar de disminuir la amenaza, sobre todo en años correspondientes al fenómeno de El Niño. El PDOT 2019 – 2023 del cantón Playas identifica los riesgos en el territorio sin evaluar los lugares específicos y los niveles de riesgo. Esta investigación aplica el método desarrollado por la Secretaría Nacional de Gestión de Riesgos y Emergencias (SNGRE) en el cantón Playas. La metodología se utilizó para evaluar el riesgo de inundación por lluvias extremas y la llegada de un tsunami. Como resultado, este cantón tiene un nivel de riesgo medio para inundaciones causadas por lluvias extremas y un nivel de riesgo alto en presencia de tsunami.
Estudio de la territorialización de la inseguridad ciudadana como componente territorial en Guayaquil, Ecuador.
Authors: Ramírez Aguilar Derly Tamara , Revilla Espinoza Maytte Ivonne
Published: December 2024

La inseguridad como componente estructurante del territorio se ha desarrollado en el Ecuador como una gestión deficiente ya que no se utilizan instrumentos de políticas públicas y control ciudadano. En el presente trabajo de investigación se evalúa la situación de la Ciudad de Guayaquil caso de estudio, y el nivel de inseguridad en el polígono señalado entre la Av. De las Américas, Av. Kennedy, Av. Delta y Av. José Santiago Castillo. El estudio analizó las posibles causas de la inseguridad, entre las que se encuentra la falta de unidades policiales en la zona. La metodología está orientada al análisis cualitativo y cuantitativo de la problemática mediante la observación participante. Además de un estudio comparativo del nivel de inseguridad en función del tipo de delito. Finalmente, se elaboró ​​el mapeo de vacíos urbanos, puntos policiales y alumbrado público que señala las zonas mediante el software ArcGIS. Se concluye que la inseguridad se encuentra con mayor frecuencia en la noche, en zonas con menor presencia de actividad urbana, por lo que se deben utilizar estrategias para incrementar el nivel de seguridad por y para los usuarios.
Analisis Bibliometrik Trend Penelitian Keputusan Investasi Saham
Authors: Wahyuni Titin , Mujanah Siti , Alif Fianto Achmad Yanu
Published: December 2024

Penelitian ini bertujuan untuk menganalisa topik penelitian keputusan investasi saham beserta trendnya serta untuk mengetahui topik lain yang dapat digunakan sebagai variable penelitian di masa mendatang. Metode penelitian yang digunakan adalah tinjauan pustaka dengan menggunakan pendekatan analisis bibliometrik melalui aplikasi publish or perish dengan database goggle scholar. Setelah hasil penelitian dilakukan pada artikel journal, diperoleh 117 artikel dari 200 artikel hasil pencarian awal. Hasil penelitian kemudian disusun melalui aplikasi mendeley dan divisualisasikan melalui aplikasi VOSviewer untuk melihat trend penelitian. Hasil penelitian menunjukkan, bahwa klasifikasi topik keputusan investasi saham terbagi menjadi 3 cluster yang terpusat individual investor, dan financial lietrascy sebagai factor luar. Covid merupakan faktor eksternal keputusan investasi saham. Penelitian ini terbatas pada jumlah kurangnya variasi topik penelitian yang ditinjau serta perangkat lunak yang digunakan.
Determinan Sustainability Report terhadap Kinerja Keuangan dengan Ukuran Perusahaan sebagai Variabel Moderasi
Authors: Arisanty Razak Linda , Arizah Ainun , Ramadhan Nurhalisa
Published: December 2024

Jenis penelitian ini merupakan penelitian dengan metode kuantitatif eksplanatory yang bertujuan menganalisis pengaruh sustainability report terhadap kinerja keuangan dengan ukuran perusahaan sebagai variabel moderasi pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Populasi yang digunakan dalam penelitian ini diambil dari laporan tahunan dan laporan berkelanjutan perusahaan manufaktur yang sudah terdaftar di Bursa Efek Indonesia periode 2018-2022. Metode yang digunakan dalam pengambilan sampel adalah metode purposive sampling sehingga diperoleh sampel sebanyak 27 perusahaan manufaktur. Pengolahan data menggunakan SPSS 23. Hasil Penelitian ini membuktikan bahwa sustainability report berpengaruh signifikan terhadap kinerja keuangan. Sedangkan hasil pengujian moderasi yang diperoleh menunujukan bahwa ukuran perusahaan memperlemah hubungan antara sustainability report terhadap kinerja keuangan.
Fungsi Audit, Praktik Keberlanjutan, dan Nilai Perusahaan Perhotelan di Indonesia
Authors: Agung Chris Petra , Inawati Wahdan Arum
Published: December 2024

Pada tahun 2023, terdapat penurunan investasi pada industri perhotelan di kawasan Asia Pasifik, akan tetapi iklim investasi pada industri perhotelan di Indonesia menunjukkan tren kenaikan. Kenaikan ini dinilai belum tentu akan bertahan lama sebab industri perhotelan dinilai rapuh terhadap ancaman perubahan iklim dan krisis lingkungan, oleh karena itu keberlanjutan menjadi sebuah isu yang perlu mendapat perhatian lebih. Salah satu cara untuk mengungkapkan praktik keberlanjutan pada perusahaan adalah melalui laporan keberlanjutan (LK) yang dirilis secara tahunan. Penelitian ini bertujuan untuk menganalisis fungsi audit dalam mempengaruhi pengungkapan LK, serta pengaruh pengungkapan LK dan ukuran perusahaan terhadap nilai perusahaan perhotelan. Dalam penelitian ini, fungi audit dirinci menjadi dua variabel yakni audit secara internal melalui variabel komite audit, dan audit secara eksternal melalui variabel auditor eksternal. Sampel penelitian ini adalah 12 perusahaan perhotelan yang termasuk dalam klasifikasi industri Bursa Efek Indonesia (BEI) yakni hotel, resor, dan kapal pesiar pada periode 2021-2023. Pengolahan data dilakukan dengan menggunakan analisis multivariat dengan Structural Equation Model (SEM). Hasil penelitian ini menunjukkan bahwa komite audit berpengaruh positif terhadap pengungkapan LK dan pengungkapan LK berpengaruh positif terhadap nilai perusahaan
The Effect of Training, Education, and Knowledge on Improving Tax Consultant Performance Karya Artha Bhakti Group
Authors: Linggi Erik Amba , Mangetan Larissa , Bangkaran Natasya , Roreng Petrus Peleng , Beloan Bertha
Published: December 2024

The Effect of Training, Education, and Knowledge on Improving the Performance of Karya Artha Bhakti Group Tax Consultants. This study aims to determine the effect of training, education, and knowledge on employee performance at Karya Artha Bhakti Group. The independent variables are training (X1), education (X2), and knowledge (X3), and the dependent variable is employee performance (Y). The population is made up of all 31 employees of Karya Artha Bhakti Group. The sampling technique is saturated sampling; data collection is done using questionnaires, and validity and reliability tests are carried out.  The data analysis techniques employed in this study include descriptive analysis, data normality tests, f tests, and t tests. This study found that training has a positive and significant effect on employee performance. Education as a positive and significant effect on employee performance, and knowledge has a positive and significant effect on employee performance, so all hypotheses are accepted. Companies should continue to increase their investment in employee training and education.