bluuebunny/crossref_metadata_2025 huggingface dataset:
Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice
Authors: Yu Yang , Shintani Takafumi , Takeuchi Yasushi , Shirasawa Takuji , Noda Masaharu
Published: August 2018

Eph receptors play pivotal roles in the axon guidance of retinal ganglion cells (RGCs) at the optic chiasm and the establishment of the topographic retinocollicular map. We previously demonstrated that protein tyrosine phosphatase receptor type O (PTPRO) is specifically involved in the control of retinotectal projections in chicks through the dephosphorylation of EphA and EphB receptors. We subsequently revealed that all the mouse R3 subfamily members (PTPRB, PTPRH, PTPRJ, and PTPRO) of the receptor protein tyrosine phosphatase (RPTP) family inhibited Eph receptors as their substrates in cultured mammalian cells. We herein investigated the functional roles of R3 RPTPs in the projection of mouse retinal axon of both sexes.PtproandPtprjwere expressed in mouse RGCs; however,Ptprjexpression levels were markedly higher than those ofPtpro. Consistent with their expression levels, Eph receptor activity was significantly enhanced inPtprj-knock-out (Ptprj-KO) retinas. InPtprj-KO andPtprj/Ptpro-double-KO (DKO) mice, the number of retinal axons that projected ipsilaterally or to the contralateral eye was significantly increased. Furthermore, retinal axons inPtprj-KO and DKO mice formed anteriorly shifted ectopic terminal zones in the superior colliculus (SC). We found that c-Abl (Abelson tyrosine kinase) was downstream of ephrin–Eph signaling for the repulsion of retinal axons at the optic chiasm and in the SC. c-Abl was identified as a novel substrate for PTPRJ and PTPRO, and the phosphorylation of c-Abl was upregulated inPtprj-KO and DKO retinas. Thus, PTPRJ regulates retinocollicular projections in mice by controlling the activity of Eph and c-Abl kinases.

SIGNIFICANCE STATEMENTCorrect retinocollicular projection is a prerequisite for proper vision. Eph receptors have been implicated in retinal axon guidance at the optic chiasm and the establishment of the topographic retinocollicular map. We herein demonstrated that protein tyrosine phosphatase receptor type J (PTPRJ) regulated retinal axonal projections by controlling Eph activities. The retinas ofPtprj-knock-out (KO) andPtpro/Ptprjdouble-KO mice exhibited significantly enhanced Eph activities over those in wild-type mice, and their axons showed defects in pathfinding at the chiasm and retinocollicular topographic map formation. We also revealed that c-Abl (Abelson tyrosine kinase) downstream of Eph receptors was regulated by PTPRJ. These results indicate that the regulation of the ephrin–Eph–c-Abl axis by PTPRJ plays pivotal roles in the proper central projection of retinal axons during development.
The nonlocal problem for the $2n$ differential equations with unbounded operator coefficients and the involution
Authors: Baranetskij Ya.O. , Demkiv I.I. , Ivasiuk I.Ya. , Kopach M.I.
Published: August 2018

We study a problem with periodic boundary conditions for a $2n$-order differential equation whose coefficients are non-self-adjoint operators. It is established that the operator of the problem has two invariant subspaces generated by the involution operator and two subsystems of the system of eigenfunctions which are Riesz bases in each of the subspaces. For a differential-operator equation of even order, we study a problem with non-self-adjoint boundary conditions which are perturbations of periodic conditions. We study cases when the perturbed conditions are Birkhoff regular but not strongly Birkhoff regular or nonregular. We found the eigenvalues and elements of the system $V$ of root functions of the operator which is complete and contains an infinite number of associated functions. Some sufficient conditions for which this system $V$ is a Riesz basis are obtained. Some conditions for the existence and uniqueness of the solution of the problem with homogeneous boundary conditions are obtained.
Signless Laplacian determinations of some graphs with independent edges
Authors: Sharafdini R. , Abdian A.Z.
Published: August 2018

Let $G$ be a simple undirected graph. Then the signless Laplacian matrix of $G$ is defined as $D_G + A_G$ in which $D_G$ and $A_G$ denote the degree matrix and the adjacency matrix of $G$, respectively. The graph $G$ is said to be determined by its signless Laplacian spectrum (DQS, for short), if any graph having the same signless Laplacian spectrum as $G$ is isomorphic to $G$. We show that $G\sqcup rK_2$ is determined by its signless Laplacian spectra under certain conditions, where $r$ and $K_2$ denote a natural number and the complete graph on two vertices, respectively. Applying these results, some DQS graphs with independent edges are obtained.
Some analytic properties of the Weyl function of a closed linear relation
Authors: Storozh O.G.
Published: August 2018

Let $L$ and $L_{0}$, where $L$ is an expansion of $L_{0}$, be closed linear relations (multivalued operators) in a Hilbert space $H$. In terms of abstract boundary operators (i.e. in the form which in the case of differential operators leads immediately to boundary conditions) some analytic properties of the Weyl function $M(\lambda)$ corresponding to a certain boundary pair of the couple $(L, L_{0}),$ are studied.

In particular, applying Hilbert resolvent identity for relations, the criterion of invertibility in the algebra of bounded linear operators in $H$ for transformation $M(\lambda) - M(\lambda_{0})$ in certain small punctured neighbourhood of $\lambda_{0} $ is established. It is proved that in this case $\lambda _{0}$ is a first-order pole for the operator-function $\left(M(\lambda )- M(\lambda_{0} )\right)^{-1} $. The corresponding residue and Laurent series expansion are found.

Under some additional assumptions, the behaviour of so called $\gamma$-field $Z_{\lambda}$ (being an operator-function closely connected to $M(\lambda)$) as $\lambda \to - \infty $ is investigated.
The growth of the maximal term of Dirichlet series
Authors: Filevych P.V. , Hrybel O.B.
Published: August 2018

Let $\Lambda$ be the class of nonnegative sequences $(\lambda_n)$ increasing to $+\infty$, $A\in(-\infty,+\infty]$, $L_A$ be the class of continuous functions increasing to $+\infty$ on $[A_0,A)$, $(\lambda_n)\in\Lambda$, and $F(s)=\sum a_ne^{s\lambda_n}$ be a Dirichlet series such that its maximum term $\mu(\sigma,F)=\max_n|a_n|e^{\sigma\lambda_n}$ is defined for every $\sigma\in(-\infty,A)$. It is proved that for all functions $\alpha\in L_{+\infty}$ and $\beta\in L_A$ the equality$$\rho^*_{\alpha,\beta}(F)=\max_{(\eta_n)\in\Lambda}\overline{\lim_{n\to\infty}}\frac{\alpha(\eta_n)}{\beta\left(\frac{\eta_n}{\lambda_n}+\frac{1}{\lambda_n}\ln\frac{1}{|a_n|}\right)}$$ holds, where $\rho^*_{\alpha,\beta}(F)$ is the generalized $\alpha,\beta$-order of the function $\ln\mu(\sigma,F)$, i.e. $\rho^*_{\alpha,\beta}(F)=0$ if the function $\mu(\sigma,F)$ is bounded on $(-\infty,A)$, and $\rho^*_{\alpha,\beta}(F)=\overline{\lim_{\sigma\uparrow A}}\alpha(\ln\mu(\sigma,F))/\beta(\sigma)$ if the function $\mu(\sigma,F)$ is unbounded on $(-\infty,A)$.
Wick calculus on spaces of regular generalized functions of Levy white noise analysis
Authors: Frei M.M.
Published: August 2018

Many objects of the Gaussian white noise analysis (spaces of test and generalized functions, stochastic integrals and derivatives, etc.) can be constructed and studied in terms of so-called chaotic decompositions, based on a chaotic representation property (CRP): roughly speaking, any square integrable with respect to the Gaussian measure random variable can be decomposed in a series of Ito's stochastic integrals from nonrandom functions. In the Levy analysis there is no the CRP (except the Gaussian and Poissonian particular cases). Nevertheless, there are different generalizations of this property. Using these generalizations, one can construct different spaces of test and generalized functions. And in any case it is necessary to introduce a natural product on spaces of generalized functions, and to study related topics. This product is called a Wick product, as in the Gaussian analysis.

The construction of the Wick product in the Levy analysis depends, in particular, on the selected generalization of the CRP. In this paper we deal with Lytvynov's generalization of the CRP and with the corresponding spaces of regular generalized functions. The goal of the paper is to introduce and to study the Wick product on these spaces, and to consider some related topics (Wick versions of holomorphic functions, interconnection of the Wick calculus with operators of stochastic differentiation). Main results of the paper consist in study of properties of the Wick product and of the Wick versions of holomorphic functions. In particular, we proved that an operator of stochastic differentiation is a differentiation (satisfies the Leibniz rule) with respect to the Wick multiplication.
Práctica docente y currículo: Un marco de análisis construccionista
Authors: Pérez-Ruiz Abel
Published: August 2018

El propósito del presente artículo es reflexionar, desde el enfoque de la construcción social, la relación de la práctica docente con el currículo de educación básica. Se establece que los sistemas curriculares no actúan como referentes de conocimiento uniformes y abstractos, sino más bien permiten la conformación de interdependencias comunicativas entre agentes que, a partir de sus creencias, valores y saberes históricamente construidos, interpretan y le dan un sentido singular a lo educativo en contextos determinados. La relevancia reside en ubicar el currículo como un mecanismo dialógico con intenciones comunicativas diversas en un escenario donde se buscan estandarizar las orientaciones de los actos de enseñanza.
Las mujeres antiperonistas, los derechos políticos femeninos y las elecciones de 1951 en Argentina
Authors: Perrig Sara
Published: August 2018

El presente artículo aborda el posicionamiento político de mujeres identificadas con el antiperonismo que se opusieron al gobierno de Juan Domingo Perón en Argentina. En 1951 Perón fue elegido presidente por segunda vez consecutiva. Ese mismo año las mujeres ejercieron por primera vez sus derechos políticos y fueron electas las primeras legisladoras argentinas. Por un lado, el artículo indaga las críticas que recibieron el gobierno, y en particular Eva Perón, desde la sanción de los derechos políticos femeninos hasta las elecciones de 1951. Por otro lado, analiza la construcción argumentativa que subyace a la caracterización del peronismo como antidemocrático con base en el contexto electoral del ‘51. Finalmente, el artículo aborda los cuestionamientos al rol político de las primeras legisladoras argentinas -todas ellas peronistas- a las cuales se acusó de subsumir sus actuaciones a los mandatos de Perón e ignorar en su función parlamentaria las demandas femeninas.
Potential Production of CH4 And N2O in Soil Profiles from Organic and Conventional Rice Fields
Authors: Anshori Arif , Sunarminto Bambang Hendro , Haryono Eko , Mujiyo Mujiyo
Published: August 2018

The horizons in soil profile will determine the magnitude of greenhouse gas production due to the difference of total organic carbon and other chemical properties. This study aimed to determine the potential production of methane (CH4) and nitrous oxide (N2O) in each horizon of soil profile from organic and conventional rice fields. Soil samples which were taken from Imogiri Bantul D.I. Yogyakarta were used to determine soil properties, the potential of CH4, and N2O productions. The correlation analysis was used to determine the relationship between the production of CH4 and N2O with soil properties. The results showed that production of CH4 and N2O will be decreased with the increase of soil depth. Production of CH4 and N2O was higher in organic rice field than in conventional rice field. The total organic carbon (TOC) correlated positively with CH4-production (r=0.89, P<0.001, n=8) and N2O-production (r=0.87, P<0.001, n=8). The nitrogen content also correlated positively with CH4-production (r=0.87, P<0.001, n=8) and N2O-production (r=0.94, P<0.001, n=8). Mitigation of CH4 and N2O emissions should consider of C and N in the soil.
Land Suitability Evaluation for Upland Rice in Tirtomoyo District, Wonogiri Regency, Indonesia
Authors: Suheri Nur Aida , Mujiyo Mujiyo , Widijanto Hery
Published: August 2018

Food cultivation, especially upland rice is needed to fulfill the needs of dryland food. It is necessary to evaluate the suitability of the land so that it can overcome land constraints to increase the productivity of upland rice in Tirtomoyo Regency. The unit of analysis is Soil Mapping Unit based on soil type map using ArcGIS 10.1 and determination of sample point based on purposive sampling method. Data analysis was done by matching between the result of soil characteristic which has been obtained with growth requirement of the upland rice. Based on the results, District Tirtomoyo divided into 4 Soil Mapping Unit. The actual land suitability class for upland rice is moderately suitable (S2) and not suitable (N). Limiting factors include rainfall, slope, erosion hazard, basic saturation, CEC, C-organic, N-total, K2O. Improvement efforts are done by arranging cropping pattern, drainage management, a making of terracing, cover crop planting, implementing organic material, and fertilizing. The suitability class of potential land of upland rice is highly suitable (S1) and marginally suitable (S3).
NOTIFICATION SCIENCE: GEOLOGICAL HERITAGE OF BEACH ROCK IN THE LY SON ISLAND
Authors: Son Nguyen Thanh , Thanh Tran Duc
Published: August 2018

Beach rock (đá bãi biển-BR) hình thành khi lớp trầm tích bãi biển trở nên rắn chắc nhờ tích tụ thứ sinh của cacbonat canxi (canxit, aragonit) kết tủa từ nước ngầm trong đới dao động của thủy triều[1]. Loại đá này từ dễ vỡ tới gắn kết tốt, bao gồm hỗn hợp các loại trầm tích cỡ hạt bột, cát và cuội sạn, có nguồn gốc từ các mảnh thân mềm, san hô, mảnh đá các loại, cả các vật liệu khác như mảnh gỗ, dừa, thậm chí cả vật dụng như chai lọ, mảnh gốm... BR thường là cát sạn kết, nhưng cũng có khi là dăm kết và cuội kết, có cấu tạo phân lớp nằm nghiêng, thường được hình thành dưới một lớp phủ mỏng trầm tích bở rời. Chúng lộ ra do xói lở bờ biển và cát phủ trên bị cuốn đi. BR thường hình thành trong đới gian triều vùng nhiệt đới hoặc cận nhiệt đới, được tìm thấy ở vùng biển Caribe, Địa Trung Hải, Biển Đỏ và vịnh Ả Rập, bờ biển Brazil, Nam Phi, Úc và ở Đông Nam Á. [1]Eric Bird, 2008. Coastal Geomorphology. 2ed. Edition. John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester.
STATUS AND TRENDS OF CHANGE IN DISTRIBUTION OF MARINE HABITATS IN NHA TRANG BAY
Authors: Long Nguyen Van , Son Tong Phuoc Hoang
Published: August 2018

Assessments of status and temporal changes in distribution of marine habitats in Nha Trang bay were conducted by using interpretation of remote sensing (Orbview 3, SPOT5, ALOS-AVNIR2 and Landsat 8-LCM) and aerial images in combination with ground truthing at 50 key sites representing coral reefs (25 sites), seagrass beds (10 sites), mangroves (5 sites), rocks (5 sites) and sand (5 sites) in 2015. A total of 812 ha of key marine habitats was recorded in 2015 including 754.1 ha of coral reefs, 52.4 ha of seagrass beds and 5.4 ha of mangroves. There was a notable decline in areas of the above marine habitats in the period of 2002 - 2015, in which 64 ha of seagrass beds (equivalent to 45%; mainly at Bai Tien, Phu Quy, Mui Nam and Vung Me, Đam Gia, Song Lo) and 117.4 ha of coral reefs (equivalent to 13.5%; mainly at Dam Gia, Duong De, Song Lo, Bai Tien and Eo Co) have been lost with an exception of increase of 3.1 ha of mangroves by new transplantation project conducted by Nha Trang MPA authority in Dam Bay during the last few years. The decline in the areas of coral reefs and seagrass beds has been caused by expansion and reclaimation of infrastructure for community and tourism development in recent years.
PHÂN TÍCH BIẾN ĐỘNG ĐƯỜNG BỜ KHU VỰC BỜ BIỂN CỬA SÔNG HẬU BẰNG TƯ LIỆU VIỄN THÁM
Authors: Tien Nguyen Ngoc , Cuong Do Huy , Uu Dinh Van , Sao Nguyen Tho , Tuan Tran Anh , Nam Le Dinh
Published: August 2018

Multi-temporal Landsat data are used for this study over the period of 1989 to 2016 with imageries of 1989, 2001, 2009 and 2016. Band rationing method and threshold technique are applied for the coastline extraction. The Digital Shoreline Analysis System ENVI 5.1, eCognition and ArcGIS 10.3 are used to calculate shoreline rate-of-change statistics from multiple historical shoreline positions. The results show that shoreline change in the Hau river mouth area has a trend of deposition between 1989 and 2016 (27 years) with the accretion area ranging from 162.68 ha to 1,210.83 ha. Meanwhile, the erosion area only ranges from 0.002 ha to 183.53 ha. The results obtained from this study set a stage for new studies to understand the morphological changes of the river mouths in the Mekong Delta and coastal areas of Hau river.
COVER, Vol. 56, N. 4 (2018)
Authors: Cover Cover
Published: August 2018

COVER, Vol. 56, N. 4 (2018)
Heavy metal pollution status in the sediment layer in World Heritage Site: Indian Sundarbans estuarine region
Authors: Chakraborty Shankhadeep , Mitra Abhijit
Published: August 2018

Heavy metals have a great ecological significance due to their toxicity and accumulative behavior. The geoaccumulation index (Igeo) in 12 stations in the UNESCO declared World Heritage Site- Indian Sundarbans estuarine region (i.e Kakdwip, Harinbari, Chemaguri, Sagar South, Lothian island, Jambu island, Frasergunge, Gosaba, Chotomollakhali, Bali island, Sajnekhali and Bagmara) were calculated for the year 2016. The sediment pollution was investigated by following the concentration of 3 heavy metals namely copper, lead and cadmium. Atomic Absorption Spectrophotometer (AAS) was used for analysis. According to the geoaccumulation index (Igeo) the results of all the 10 stations were analyzed and discussed in details.
Challenging the Hidden Curriculum through Problem Based Learning: A reflection on Curricular Design
Authors: Hough Lorena , Hegazi Iman
Published: August 2018

This article was migrated. The article was marked as recommended. Problem-Based Learning pedagogy has been around since the late 1960s. However, PBL case-writing still constitutes an arduous task with much debate about how the cases should be written. The influence of the different PBL-writing styles and approaches have upon medical students requires attention and research. The Western Sydney University medical school has recently undergone a PBL renewal project, redesigning and rewriting 52 high quality PBL cases. Much thought and consideration were exerted in the planning and delivery of this project with a focus not only on the deep-learning and understanding of the basic and clinical sciences, but also on the importance of patient-centeredness. In this paper, we emphasize how language used in PBL cases can have a profound impact on students through implicit learning and the hidden curriculum. We also recommend having a writer, experienced in the use of narrative and emotive language, in addition to clinicians and medical educators in the authorship of PBL cases.
An Exploratory Study of a Novel Adaptive e-Learning Board Review Product Helping Candidates Prepare for Certification Examinations
Authors: Healy Michael , Petrusa Emil , Axelsson Carl Gustaf , Wongsirimeteekul Praelada , Hamnvik Ole-Petter , O’Rourke Matthew , Feinstein Roger , Steeves Ruth , Phitayakorn Roy
Published: August 2018

This article was migrated. The article was not marked as recommended. Objectives: Online board-review products are widely used to prepare for high-stakes examinations; however, it is unclear if these products are truly helpful and which features are most useful. This study examined the user ratings of an e-learning examination-preparation product and its impact on first-time American Board of Internal Medicine Certifying Examination (ABIM-CE) test takers. Methods: 4,400 users were anonymously surveyed between 2015 and 2017 to determine their level of satisfaction with the NEJM Knowledge+ Internal Medicine Board Review (NEJM Knowledge+) product and their board-exam passage rate. Results:The responding users' (n=836) average ratings of NEJM Knowledge+'s content, relevance, components, and features were high. Similarly, a subgroup of responding users from the United States who primarily used NEJM Knowledge+ to prepare for an initial ABIM-CE between 2014 and 2016 (n=153) rated the content, relevance, components, and features high, with practice exams, adaptive delivery of questions, and reports on progress, performance, and metacognition as the most valuable features. Importantly, this subgroup of users passed the ABIM-CE on their first attempt at a significantly higher rate than the national average (95% vs 89%, z=2.6397, p=0.0083). Conclusion:An e-learning examination-preparation product that features adaptive delivery of questions, offers detailed feedback, and analyzes overall metacognition may be an effective tool for first-time test takers preparing for initial certifying examinations.
Doulas como dispositivos para humanização do parto hospitalar: do voluntariado à mercantilização
Authors: Barbosa Murillo Bruno Braz , Herculano Thuany Bento , Brilhante Marita de Almeida Assis , Sampaio Juliana
Published: August 2018

RESUMO O artigo analisa, a partir da perspectiva das doulas, sua inserção na assistência ao parto em hospital público de João Pessoa. Trata-se de estudo qualitativo, que utilizou a Tenda do Conto, com seis doulas, para a produção de dados, em 2017. A inserção das doulas no hospital não foi resultante de uma mudança de paradigma assistencial, produzindo resistências. Num cenário hostil à sua atuação, as doulas funcionam como gatilho de tensões entre modelos de cuidado divergentes, o que gera sofrimento nas próprias doulas, demandando estratégias de enfrentamento, a saber: afastarem-se do voluntariado; tornarem-se institucionalizadas; ou serem cooptadas pelo mercado do parto humanizado no âmbito privado.
Genome prediction accuracy of common bean via Bayesian models
Authors: Barili Leiri Daiane , Vale Naine Martins do , Silva Fabyano Fonseca e , Carneiro José Eustáquio de Souza , Oliveira Hinayah Rojas de , Vianello Rosana Pereira , Valdisser Paula Arielle Mendes Ribeiro , Nascimento Moyses
Published: August 2018

ABSTRACT: We aimed to apply genomic information based on SNP (single nucleotide polymorphism) markers for the genetic evaluation of the traits “stay-green” (SG), plant architecture (PA), grain aspect (GA) and grain yield (GY) in common bean through Bayesian models. These models were compared in terms of prediction accuracy and ability for heritability estimation for each one of the mentioned traits. A total of 80 cultivars were genotyped for 377 SNP markers, whose effects were estimated by five different Bayesian models: Bayes A (BA), B (BB), C (BC), LASSO (BL) e Ridge regression (BRR). Although, prediction accuracies calculated by means of cross-validation have been similar within each trait, the BB model stood out for the trait SG, whereas the BRR was indicated for the remaining traits. The heritability estimates for the traits SG, PA, GA and GY were 0.61, 0.28, 0.32 and 0.29, respectively. In summary, the Bayesian methods applied here were effective and ease to be implemented. The used SNP markers can help in the early selection of promising genotypes, since incorporating genomic information increase the prediction accuracy of the estimated genetic merit.
PERCEPÇÃO DO IMPACTO NO TRABALHO DE UM TREINAMENTO ON-LINE SOBRE PREVENÇÃO DE LESÃO POR PRESSÃO
Authors: Aroldi Juscilynne Barros da Costa , Peres Heloisa Helena Ciqueto , Mira Vera Lucia
Published: August 2018

RESUMO Objetivo: avaliar a percepção do impacto em amplitude e o suporte à transferência do treinamento on-line sobre prevenção de lesão por pressão. Método: estudo exploratório-descritivo, desenvolvido no município de São Paulo, no Hospital Universitário da Universidade de São Paulo. A população da pesquisa abrangeu 97 enfermeiros que atuavam em unidades com pacientes de maior risco de desenvolvimento de lesão por pressão. Além disso, foram aplicados dois instrumentos para avaliação de suporte à transferência e de percepção do impacto. Os dados foram submetidos às análises estatísticas descritivas e coeficientes de correlação de Pearson, com auxílio do software R® 3.2.2. O coeficiente Alpha de Cronbach foi utilizado para verificar a consistência interna das escalas. Resultados: a percepção de impacto do treinamento no trabalho apresentada teve um valor médio de 7,05±1,60. Na avaliação do Suporte à Transferência, a média foi de 5,82±1,45. A análise de impacto no trabalho evidenciou valores significativos, indicando que houve transferência e construção de conhecimentos, bem como habilidades desenvolvidas pelos enfermeiros no treinamento on-line para a prática assistencial na prevenção de lesão por pressão. A avaliação do suporte à transferência permitiu examinar o tipo de ambiente encontrado pelo enfermeiro para fazer com que os conteúdos assimilados fossem transferidos para sua prática profissional. Conclusão: os resultados das avaliações evidenciam que o treinamento on-line agrega conhecimento aos enfermeiros e contribuem para a implementação de novas tecnologias educacionais nas ações permanentes de treinamento e desenvolvimento dos profissionais da enfermagem.
Cosmarium bromelicola sp. nov. (Desmidiaceae, Zygnematophyceae), a new desmid species from Northeast Brazil
Authors: Ramos G. J. P. , Bicudo C. E. M. , Moura C. W. N.
Published: August 2018

Abstract Cosmarium bromelicola sp. nov. is a new desmid species described from samplings carried out in bromeliad tanks (phytotelmata) from an area of rocky outcrops at Serra da Jiboia, Bahia State, Northeast Brazil. Presence of subtrapeziform cells with a deep depression at the apical region and twisted X-shaped cell in side view are the diagnostic features for the species. Relationships with the morphologically closest taxa are discussed.
Impacto do grau de uveíte em diferentes tipos de úlceras de córneas em cães submetidos ao enxerto pediculado de conjuntiva bulbar - 34 casos
Authors: Amorim T.M. , Ribeiro A.P. , Ruiz T. , Dower N.M.B. , Madruga G. , Schroder D.C. , Monteiro G.B. , Rodrigues B.E.
Published: August 2018

RESUMO O presente trabalho objetivou avaliar os resultados de 34 olhos submetidos ao enxerto conjuntival pediculado (ECP) em ceratites ulcerativas profundas (n=5), em ceratites ulcerativas com colagenólise (n=2), descemetocele (n=7), perfuração corneal (n=15) e prolapso de íris (n=5). Os impactos do grau de uveíte e da integridade da córnea foram correlacionados com presença e ausência de visão por tabelas de contingência. Raças braquicefálicas foram acometidas em 91,11% dos casos. O número de córneas consideradas perfuradas [20/34 (58,82%)] foi maior que o de córneas íntegras [14/34 (41,17%)]. Ao 50º dia de pós-operatório, o número de olhos visuais que apresentavam córneas íntegras previamente às cirurgias (n=13) não diferiu significativamente dos olhos com córneas perfuradas (n=12) (P=0,05). Avaliações relativas ao grau de uveíte, revelaram que a metade dos casos foi considerada severa [17/34 (50%)] e na outra metade as uveítes foram consideradas discretas. Dos 17 casos que apresentaram uveíte severa, oito recuperaram a visão. Já nos 17 olhos onde a uveíte foi considerada leve, 15 mantiveram a visão ao final do período de avaliação. Apesar de a integridade da córnea não se correlacionar com a severidade da uveíte (P=0,48), constatou-se que o número de olhos visuais com uveíte discreta foi significativamente maior que os olhos com uveíte severa (P=0,006). Neste estudo, a taxa geral de sucesso visual após ECP foi de 73,52% e a integridade da córnea não exerceu impacto significativo sobre a manutenção da visão. Todavia, olhos acometidos por uveítes severas apresentaram menor chance de recuperar a visão.
Acoustic radiation force impulse elastography of the eyes of brachycephalic dogs
Authors: Abreu T.G.M. , Feliciano M.A.R. , Renzo R. , Kobashigawa K.K. , Chacaltana F.D.Y.C. , Crivelaro R.M. , Silveira C.P. B. , Cruz N.R.N. , Aldrovani M. , Maronezi M.C. , Silva P.A. , Thiesen R. , Laus J.L.
Published: August 2018

ABSTRACT Eyes from brachycephalic dogs were studied by acoustic radiation force impulse (ARFI) elastography to establish quantitative and qualitative reference values related to the shape and rigidity of some ocular structures. Eighty-four eyes from 42 adult brachycephalic dogs were included in this study. Animals were subjected to physical, laboratory, and ophthalmic examinations. Following confirmation of good health, the dogs were subjected to ultrasonography and ARFI elastography, emphasizing the optic nerve, ciliary body, and lens. On qualitative elastography, homogeneous characteristics were observed on the ciliary body and optic nerve. Aqueous and vitreous humors were visualized as mosaic-like images. Quantitative elastography showed the mean optic nerve shear wave velocity (SWV) was 1.01±0.27m/s, temporal ciliary body was 0.91±0.24m/s, and nasal ciliary body was 0.91±0.3m/s. The SWV of the lens values were out of range, this value was not detectable by this software. Elastography has proved to be a non-invasive procedure and feasible in dogs. The establishmentof the parameters of degree of rigidity of ocular structures will serve as a baseline for animals with eye disorders. Results may be extrapolated to primary research on the applicability of ARFI in the evaluation of ocular bulb in humans.
Variabilidade genética de 12 loci de microssatélites em galinhas crioulas Canela-Preta
Authors: Carvalho D.A. , Bonafé C.M. , Rodriguez-Rodriguez M.D.P. , Almeida M.J.O. , Sarmento J.L.R. , Britto F.B. , Silva M.A.
Published: August 2018

RESUMO Esta pesquisa foi realizada com o objetivo de se conhecer a variabilidade genética de 12 loci de microssatélites em galinhas crioulas Canela-Preta. Foram coletadas amostras de sangue de 118 galinhas crioulas Canela-Preta, provenientes de três municípios do estado do Piauí (Oeiras, Queimada Nova e Teresina). Após extração do DNA, foram utilizados marcadores para 12 loci de microssatélites: LEI0192, LEI0209, LEI0212, LEI0217, LEI0221, LEI0234, LEI0237, LEI0248, LEI0258, MCW0081, MCW0183 e MCW0213, que foram amplificados pela técnica de reação em cadeia da polimerase (PCR). Foram obtidos 408 alelos (somando os alelos dos 12 loci), com os fragmentos variando entre 50 e 460 pares de bases. O número de alelos variou de 15 (MCW0081) a 52 (LEI0212), com média de 31,5 alelos por locus. A média de heterozigosidade esperada e o conteúdo de informações polimórficas foram, respectivamente, 0,887 e 0,909. Foram observados desvios no equilíbrio de Hardy-Weinberg e valores positivos do índice de fixação com excesso de homozigotos. Os microssatélites utilizados mostraram-se polimórficos e podem ser usados para investigações genéticas em galinhas Canela-Preta. As galinhas dos plantéis avaliados apresentam grande variabilidade gênica, o que as qualifica como importante fonte de recursos genéticos e, consequentemente, faculta a utilização delas em programas de melhoramento genético animal.
Distribution of selenium in sheep treated with dipheny diselenide
Authors: Leal M.L.R. , Rocha J.B.T. , Corte C.L.D. , Aires A.R. , Rocha J.F.X. , Zanatta R.S. , Carpes J.L.S. , Szinwelski G.A. , Stefanello S. , Pivoto F.L.
Published: August 2018

ABSTRACT The aim of the present study was to report the in vivo distribution of selenium in sheep. For this, animals were allocated into two groups (control group and treated group) and kept in metabolic cages for a period of 37 days. The treated group received a single dose (6µmol/kg) of Diphenyl Diselenide, intravenously. Plasma and erythrocytes samples were collected at different times. Adipose tissue, muscles (latissimusdorsi, semitendinosus, and supra-scapular) heart, liver, lung, kidney, intestine and brain were sampled at 30 days post-treatment, in order to determine the selenium concentration. The results demonstrated that the selenium, from the Diphenyl Diselenide group, was higher in erythrocytes (4.8mg/L, six hours post-treatment) when compared with the control sheep. The deposition of selenium occurred in the liver (7.01µg/g), brain (3.53µg/g) and kidney (2.02µg/g). After 30 days of a single intravenous injection of Diphenyl Diselenide, liver was the main organ of selenium deposition.
Diretrizes curriculares nacionais das profissões da Saúde 2001-2004: análise à luz das teorias de desenvolvimento curricular
Authors: Costa Dayane Aparecida Silva , Silva Roseli Ferreira da , Lima Valéria Vernaschi , Ribeiro Eliana Cláudia Otero
Published: August 2018

O objetivo desta pesquisa foi analisar as Diretrizes Curriculares Nacionais (DCNs) do período de 2001 a 2004 para 14 carreiras da Saúde. Foi conduzido um estudo descritivo exploratório entre 2015 e 2016, mediante a análise documental das DCNs conforme a Resolução nº 287/1998. A coleta dos dados foi por consulta ao site do MEC/Portal. Para análise dos dados, utilizou-se uma matriz analítica com dois eixos/categorias: Currículo (processo de avaliação; processo de ensino-aprendizagem; e organização curricular) e Perfil Profissional (Perfil Profissional; Cuidado com a Saúde; Educação na Saúde; e Gestão em Saúde). Os resultados mostram que as DCNs mantiveram aspectos do modelo tradicional de ensino, com pouca qualificação nas orientações pedagógicas inovadoras. A associação desses achados com a presença de lacunas na articulação entre formação, necessidades de saúde e demandas do Sistema Único de Saúde (SUS) apontam o desafio de uma maior produção desse tipo de análise e da revisão das DCNs.
Influence of Social Skills and Stressors on Academic Achievement in the Sixth-Grade
Authors: Jovarini Neidiany Vieira , Leme Vanessa Barbosa Romera , Correia-Zanini Marta Regina Gonçalves
Published: August 2018

Abstract Transition to middle school (MS) expressions changes in interpersonal relations and academic demands that can influence the academic achievement of students. This study aimed to evaluate the influence of social skills and perception of school stressors of students as predictors of academic achievement in the transition to the 6th grade of the MS. 214 students (aged 11 to 17 years) participated, of both genders of the 6th grade, of the state of Amazonas. Students answered the Social Skills Inventory for Adolescent and the Inventory of School Stressors. The predictive model indicated that the social skills of assertiveness, empathy and emotional approach and school stressors related to stress related to the student’s role predicted 18% of the academic achievement. The survey data can be used in future interventions with students, their families and teachers.
Comparative effects of the Mandibular Protraction Appliance in adolescents and adults
Authors: Furquim Bruno D’Aurea , Janson Guilherme , Cope Laura de Castro Cabrera , Freitas Karina Maria Salvatore , Henriques José Fernando Castanha
Published: August 2018

ABSTRACT Objective: The aim of this study was to compare the skeletal, dental, and soft tissue effects of the Mandibular Protraction Appliance (MPA) application in adolescent and adult Class II malocclusion patients. Methods: The sample comprised the pretreatment and posttreatment lateral cephalograms of 39 subjects presenting Class II malocclusion treated with the MPA and fixed appliances. Sample was divided into two groups: Group 1 comprised 23 subjects (10 male; 13 female), at a mean pretreatment age of 11.75 years, with a mean treatment time of 3.32 years; Group 2 included 16 subjects (7 male; 9 female), at a mean pretreatment age of 22.41 years, with a mean treatment time of 4.24 years. Intergroup comparison of the initial and final stages and treatment changes between the groups was performed with t tests, at p< 0.05. Results: The adults showed less significant amounts of skeletal, dentoalveolar and soft tissue changes than the adolescents. There was significantly greater palatal tipping of the maxillary incisors and retrusion of the upper lip in the adolescents. The adult group showed greater mandibular incisor proclination in the posttreatment stage. Conclusion: Adult patients treated with MPA showed less significant amounts of skeletal, dentoalveolar and soft tissue changes than adolescents.
Efeito do programa integral de reabilitação vocal em professoras com disfonia comportamental
Authors: Cavalcanti Nilceneide Ramos , Souza Bárbara Oliveira , Gama Ana Cristina Côrtes , Medeiros Adriane Mesquita de
Published: August 2018

RESUMO Objetivo analisar os efeitos do Programa Integral de Reabilitação Vocal (PIRV) e os estágios motivacionais durante a terapia de voz em professoras com disfonia comportamental. Método estudo observacional longitudinal retrospectivo com dados de prontuários de 33 professoras referente à análise perceptivo-auditiva, acústica, autopercepção vocal e Protocolo de Índice de Desvantagem Vocal (IDV-10) nas situações pré e pós-fonoterapia e estágios motivacionais de adesão ao tratamento. Resultados Na avaliação perceptivo-auditiva da voz, 64,7% das participantes melhoraram a qualidade vocal pós-fonoterapia. Quando comparados os momentos pré e pós-fonoterapia, observou-se que 82,4% das professoras melhoraram a voz segundo a autopercepção. O IDV-10 não mostrou diferença entre os momentos pré e pós-fonoterapia (p=0,879). Na análise acústica da voz, observou-se melhora da média de todos os parâmetros avaliados. Houve associação estatisticamente significante na análise entre os momentos pré e pós-fonoterapia apenas nas variáveis tempo máximo de fonação e shimmer. A maioria das professoras encontrou-se no estágio de contemplação na escala URICA-VOZ. Não houve significância estatística na análise de associação entre o IDV-10, análise perceptivo-auditiva, tempo máximo de fonação e parâmetros da análise acústica com a autopercepção vocal das professoras e com a avaliação perceptivo-auditiva da voz. Conclusão o uso do PIRV para tratamento de disfonias comportamentais promoveu resultados positivos quando comparada a avaliação vocal antes e após tratamento. Quanto à motivação, as professoras acreditavam com firmeza na possibilidade de enfrentar o problema, mas ainda sem muito esforço para mudar essa situação.
WATER-PERFUSED HIGH-RESOLUTION ANORECTAL MANOMETRY (HRAM-WP): THE FIRST BRAZILIAN STUDY
Authors: VIEBIG Ricardo Guilherme , FRANCO Janaina Tomiye Yamakata , ARAUJO Sergio Viebig , GUALBERTO Daniel
Published: August 2018

ABSTRACT BACKGROUND: High resolution anorectal manometry (HRAM-WP) allows more simplified, objective, and uniform data acquisition and interpretation of the test results. OBJECTIVE: To validate a HRAM under water perfusion (Alacer Biomédica) with a 24-channel probe and to compare the results of anorectal manometry with other systems. METHODS: Individuals without critical evacuation disorders were selected. Patients with incontinence, anal surgery, dyssynergia or sphincter injury were excluded. The test was performed with an Alacer Biomédica 24 channel manometry system under water perfusion, with a probe configured with 6 levels of 4 radial channels, separated from each other by 0.8 mm. The mean pressures for the functional channel were determined, in states of rest (RMP), contention effort (CMP) and evacuation effort (EEMP). The pressure extension of the sphincter was also tabulated in cm. The results were compared with those available in recent literature. RESULTS: Fifty patients were studied (20 men; 30 women). Overall, the following results were obtained: the RMP was 76.9±3.0 mmHg, the CMP was 194.2±9.4 mmHg, and EEMP was 88.2±3.7 mmHg. When classified according to the gender, for men: RMP was 72.2±3.0 mmHg, CMP was 229.5±17 mmHg, and EEMP was 91.4±7.0. For women, RMP was 79.8±4.0 mmHg, CMP was 170.7±8, and EEMP was 86.1±4.3 mmHg. The sphincter gauge extension for both genders was 3.1±0.09 cm (men 3.3±0.1; women 3.0±0.1). DISCUSSION: Studying HRAM-WP has become much easier. Non-mobilization of the sensor causes less discomfort and artefacts with a lower assessment time. In this study, small differential values between both sexes during rest were observed, highlighting a greater containment force in men. No difference in sphincter extension was noted. The results of this study are consistent with that of existing reports and with those obtained using solid state probes. CONCLUSION: The perfusion system yielded results similar to that of solid state systems. Further studies to evaluate parameters with respect to pelvic dyssynergia and incontinence need to be conducted. Additionally, to determine if the vector volume can furnish new information in terms of functional and anatomical aspects.
CAN THREE-DIMENSIONAL ANORECTAL ULTRASONOGRAPHY BE INCLUDED AS A DIAGNOSTIC TOOL FOR THE ASSESSMENT OF ANAL FISTULA BEFORE AND AFTER SURGICAL TREATMENT?
Authors: MURAD-REGADAS Sthela Maria , REGADAS FILHO Francisco Sergio P , HOLANDA Erico de Carvalho , VERAS Lara Burlamaqui , VILARINHO Adjra da Silva , LOPES Manoel S
Published: August 2018

ABSTRACT BACKGROUND: There is no a clear knowledge concerning the division of any part of the anal sphincter complex and the effect of this procedure on the function of the anal canal during the treatment of perianal fistula. OBJECTIVE: To evaluate the usefulness of 3D anorectal ultrasound in the assessment of anal fistula, quantifying the length of the sphincter muscle to be transected, selecting patients for different approaches and identifying healing, failure or recurrence after the surgical treatment. METHODS: A prospective study included patients with primarily cryptogenic transsphincteric anal fistula assessed by fecal Incontinence score, tri-dimensional anorectal ultrasound and anal manometry before and after surgery. Based on 3D-AUS, patients with ≥50% external sphincter or external sphincter+puborectalis muscle involvement in males and ≥40% external sphincter or external sphincter+puborectalis muscle in females were referred for the ligation of the intersphincteric tract (LIFT) or seton placement and subsequent fistulotomy; and with <50% involvement in males and <40% in females were referred to one-stage fistulotomy. After surgery, the fibrosis (muscles divided) and residual muscles were measured and compared with the pre-operative. RESULTS: A total of 73 patients was included. The indication for the LIFT was significantly higher in females (47%), one-stage fistulotomy was significantly higher in the males (46%) and similar in seton placement. The minor postoperative incontinence was identified in 31% of patients underwent sphincter divided and were similar in both genders. The 3D-AUS identified seven failed cases. CONCLUSION: The 3D ultrasound was shown to be an effective method in the preoperative assessment of anal fistulas by quantifying the length of muscle to be divided, as the results were similar at the post-operative, providing a safe treatment approach according to the gender and percentage of muscle involvement. Additionally, 3D ultrasound successfully identified the healing tissue and the type of failure or recurrence.
Gestão do cuidado de um paciente com Doença de Devic na Atenção Primária à Saúde
Authors: Fabrizzio Greici Capellari , Gonçalves Júnior Erádio , Cunha Kamylla Santos da , Kahl Carolina , Santos José Luís Guedes dos , Erdmann Alacoque Lorenzini
Published: August 2018

RESUMO Objetivo Descrever a gestão do cuidado de uma pessoa acometida pela Doença de Devic no contexto da Atenção Primária à Saúde. Método Estudo de caso clínico-qualitativo pelo estado de saúde do paciente, em um Centro de Saúde do município de Florianópolis, com um paciente com Doença de Devic acompanhado pela Equipe de Saúde da Família. A coleta de dados ocorreu a partir de prontuário eletrônico, documentos de domínio do paciente, bem como de entrevista semiestruturada com o participante. Foram respeitados os aspectos éticos da pesquisa com seres humanos. Resultados As categorias foram definidas segundo critérios de relevância, buscando relatar o caso do estudo, apresentar o projeto terapêutico singular implementado e descrever a percepção do paciente sobre sua situação de saúde. Conclusão A acupuntura e auriculoterapia foram realizadas com êxito, evidenciando melhora no quadro álgico do paciente, o que pode contribuir para novas possibilidades de cuidados. Apesar disso, não foram utilizadas todas as ferramentas de cuidado disponíveis, visto a gama de terapias complementares de cuidados para além do enfoque medicamentoso.
Programas de Controle de Infecção Hospitalar: avaliação de indicadores de estrutura e processo
Authors: Giroti Alessandra Lyrio Barbosa , Ferreira Adriano Menis , Rigotti Marcelo Alessandro , Sousa Álvaro Francisco Lopes de , Frota Oleci Pereira , Andrade Denise de
Published: August 2018

RESUMO Objetivo Avaliar Comissões de Controle de Infecção Hospitalar quanto aos indicadores de estrutura e processo dos Programas de Controle de Infecção Hospitalar. Método Estudo transversal e descritivo, realizado com Comissões de hospitais registrados no Cadastro Nacional de Estabelecimentos de Saúde. A coleta de dados primários e secundários foi realizada por meio de entrevista estruturada, utilizando-se de instrumentos validados e verificação de documentos, respectivamente. Resultados Participaram da pesquisa 14 Comissões. Evidenciaram-se médias de conformidade de 80,58% para o indicador de avaliação da estrutura técnico-operacional, 60,77% para o indicador das diretrizes operacionais de prevenção e controle de infecção, 81,59% para o indicador de avaliação do sistema de vigilância epidemiológica e 63,44% para o indicador de avaliação das atividades de controle e prevenção de infecção hospitalar. Conclusão Entre os quatro instrumentos aplicados para a avaliação dos Programas de Controle de Infecção Hospitalar, apenas dois deles apresentaram resultado superior a 80,0% de conformidade, os relativos às avaliações da estrutura técnico-operacional e à vigilância epidemiológica.
Contribution of tracks to dynamic behaviour of railway bridges
Authors: Bigelow Hetty , Hoffmeister Benno , Feldmann Markus , Zabel Volkmar
Published: August 2018

The design of (single-span) railway bridges has to meet the challenge of reliable assessment of potential resonance risks. A simplified resonance check based on a bridge's fundamental frequency is provided in the European standard BS EN 1991-2. However, filler beam bridges often do not fulfil the requirements when assessed by calculation only. Measurements usually reveal much higher fundamental frequencies, thus indicating that the calculated frequencies are inaccurate. The difference between calculations and measurements is strongly connected to the mostly unconsidered stiffness contributions of non-structural elements such as ballast or maintenance workways connected to the deck. BS EN 1991-2 provides recommendations for modelling and calculation of the combined track/structure system for the determination of load effects, thus introducing restraining effects of the tracks in the model. In this paper, substitutional rotational springs are derived from the parameters given in DIN EN 1991-2 . These can be added to a simple beam single-span model, reducing the modelling complexity significantly while providing equivalent results. Furthermore, a formula for calculation of the fundamental frequency is derived from an equivalent single degree-of-freedom system considering the rotational spring stiffness. Measured and calculated natural frequencies of existing filler beam bridges are used to demonstrate the achievable improvements in calculation.