bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining the Land Use Act of 1978 and Its Effects on Tenure Security in Nigeria: A Case Study of Ekiti State, Nigeria
Authors: Babalola Kehinde Hassan , Hull Simon Antony
Published: November 2019

The Land Use Act of 1978 (LUA) has failed to achieve some of its objectives. The rural poor and the vulnerable are those most affected. The failure is ascribed to problems inherent in the Act and poor implementation. This paper discusses the effect of the LUA on the customary ownership of land and its effect on the tenure security of the rural poor. Using a conceptual framework for guiding cadastral systems development, the critical areas of the LUA as pertains to tenure security are analysed for the degree of their success, sustainability, and significance. The framework looks at the underlying theory, the drivers of change, the change process, and the land administration system. A mixed methodology approach was adopted for the study, using a single case study. Three groups of respondents contributed to the study: land professionals, civil servants and students. The study found that securing title to land is difficult, compensation provisions need to be reviewed, formal land registration is not in the interest of the poor, land is not available at an affordable rate, land speculators are still active in Nigerian land markets, the composition of the two committees is inadequate, and the refusal to grant certificates to people below the age of 21 is age biased. It further revealed that the power granted to the governor is enormous and unnecessary. The findings showed that the LUA is both effective in some areas and dysfunctional in others. This is because of the age of the Act and the lack of a pro-poor policy focus. Based on these findings recommendations were made, including that a new policy be enacted that includes pro-poor policies and customary laws. The LUA is found to be useful in urban areas, but not in solving land-related problems in rural areas. This study provides an understanding of the legal holding of land in Nigeria.
Cell cultures, transfection and treatments v1
Authors: Herrera Federico
Published: November 2019

Human glioblastoma U251 cells and rat brain glioma C6 cells were grown to confluence in Dulbecco´s Minimal Essential Medium (DMEM) supplemented with 10% (v/v )fetal bovine serum (FBS),1%(v/v)Penicillin-Streptomycin and 1% (v/v) L-glutamine, and maintained at 37ºC in a humidified atmosphere containing 5% CO2. Medium was changed every other day and cells were passed once a week by trypsinization. Briefly, cells were incubated with TrypLE Express dissociation reagent for 5 min at 37ºC for cell detachment, followed by a centrifugation step at 300 g for 5 min at room temperature and sub-cultured according to the desired dilution. For fluorescent microscopy and single-molecule tracking experiments, 3×105 cells were grown on 35 mm glass-bottom dishes (21 mm glass surface diameter, Ibidi GmbH, Gräfelfing, Germany). For flow cytometry, 3×105 cells were seeded on 6-well plates (35 mm diameter, Corning, NY,USA). For Western blotting, 8×105 cells were seeded on 60 mm dishes (Orange Scientific, Braine-L’Alleud,Belgium). Twenty-four hours after seeding, cells were transiently transfected with 1 µg of the corresponding DNA constructs using jetPRIME transfection reagent (Polyplus transfection, Illkirch, France) in a proportion of 3:1 (µL of transfection reagent: µg of DNA). All drugs and HaloTag ligands were diluted in DMSO (100% v/v). To test the neuroprotective activity of CNB-001 (0.1, 1 or 10 µM), cells were treated for 20 min before transfection and incubated for 24 h at 37ºC. For single-molecule experiments, 24 h after transfection, serum was removed for 2 h, and cells were treated with LIF (100 ng/ml), Nocodazole (10 µM) or Latrunculin B (10 µM) for 2 h at 37ºC in serum-free medium. Cells were then incubated with JF647 (100nM), JF549 (100 nM) or PA-JF549 (1nM) HaloTag ligands in serum-free medium for 20 min at 37ºC.Subsequently, cells were washed twice with sterile PBS. At the end of the final wash, the medium was changed to Leibovitz’s L-15 without phenol red.
Microscopy v1
Authors: Quiteres Ricardo , Crevenna Alvaro , Hensel Zach , Herrera Federico
Published: November 2019

Live-cell images of U251 cells were acquired at Instituto Gulbenkian de Ciência on a commercial widefield Nikon High Content Screening microscope, equipped with a 100x/1.45 plan-apo oil-immer- sion objective and an Andor Zyla 4.2 Scientific complementary metal-oxide-semiconductor (sCMOS) camera. To image eGFP/Venus–fused proteins, a 470 nm laser line, and GFP fluorescence filtersets were used and for the imaging of HaloTag-fused proteins, a 635 nm laser line and Cy5 fluorescent filtersets were used. An exposure time of 80 ms was used and the camera readout bandwidth was set to 200MHz.The resulting pixel size was 65 nm using a 1024x1024 pixel as field of view. All acquisition were done at room temperature.The microscope, cameras, and hardware were controlled through Nikon Elements software. Images were analyzed by means of the ImageJ free software.Single-molecule imaging and Super-Resolution Radial Fluctuations (SRRF) imaging were performed on a Leica DMI6000 inverted microscope using a 100x/1.46 a-plan apochromat oil immersion objective. A 561 nm excitation laser (Coherent Sapphire) was set to 50 mW resulting in an effective power density of ~2.3kW/cm2. The laser beam was passed through a custom filter cube (Chroma Technology) with a zet405/561x excitation filter, a zt405/561/657rpc-uf2 dichroic beam splitter, and an et610/75m emission filter. Fluorescent light was imaged on an Evolve512 electron multiplying charge-coupled device (EM-CCD) camera (Photometrics) after additional 1.6x magnification. An EM gain of 300 was used and the camera read out band width was set to 10 MHz. The resulting pixel size was 100 nm using a 512 x 512 pixel as field of view. The incubation chamber was maintained at 37°C. The microscope , cameras, and hardware were controlled through MetaMorph software (Molecular Devices). For single-molecule experiments and for each cell, 1000 frames were acquired at 33 ms exposure time with no interval between frames. No photoactivation was necessary as spontaneous photoactivation of PA-JF549 combined with photobleaching by 561 nm illumination gave a reasonable density of single molecules.The Trackmate ImageJ plugin was used to detect, fit and track individual GFAP molecules in living cells (A-C). For the detection of GFAP molecules, we selected a LoG detector and an estimated blob diameter of 0,4 mm and a threshold of 1500. For the tracking, we used a simple LAP tracker with a linking maximum distance of 0,5 mm, a gap-closing maximum distance of 0,5 mm and a gap-closing max frame gapof0.The average diffusion of GFAP molecules and its fractions, per individual cell, were calculated by fitting the SpotOn 2-state(bound-free) kinetic model (0,05mm2/s as maximum Dbound and 0,02 mm2/s as minimum Dfree) to the distribution of translocations for individual molecules, obtained with TrackMate. For SRRF imaging, 100 frames were acquired for each cell. SRRF images were generated by running the NanoJ-SRRF ImageJ plugin on groups of 100 diffraction-limited images using the default settings.
On Possibility of Machine Learning Application for Diagnosing Dementia by Eeg Signals
Authors: Dorovskih I.V. , Senko O.V. , Chuchupal V.Ya. , Dokukin A.A. , Kuznetsova A.V.
Published: November 2019

The purpose of this study was to investigate the possibility to use electroencephalography for early diagnostics of dementia and for objective assessment of disease severity and neurometabolic treatment results. The study was based on application of machine learning methods for computer diagnosis of dementia by the energy spectra of EEG signals. Effectiveness of various machine learning technologies was investigated in order to separate different groups of patients with varying severity of dementia from healthy ones and patients with pre-dementia disorders according to the vectors of spectral indicators. Applying of cross-validation procedure showed that separation of the group with dementia from the group of people with normal physiological aging and groups of young people reaches 0.783 and 0.786, respectively by parameter ROC AUC. The results of the study allow to make an assumption, that the algorithmic assessment of dementia severity by EEG corresponds to the actual course of the disease. So, the number of cases with algorithmically identified positive dynamics significantly exceeds the number of cases with algorithmically detected negative dynamics after neurometabolic therapy in the group with mild dementia. In a combined group with both average and heavy severity of the disease such an increase was not observed.
THE IMPLEMENTATION OF THE RISK-ORIENTED TRAINING APPROACH IN THE UNIVERSITIES WITH SPECIFIC EDUCATIONAL CONDITIONS
Authors: Artemov V. , Lytvynenko N.
Published: November 2019

The features of the risk-oriented approach when used for educational purposes in higher education institutions with specific learning conditions are revealed. The ways of the risk-oriented thinking formation among employees of security structures are determined.It is assumed that the semantic space associated with the moral proper, includes the following concepts: "permissible", "unacceptable", "compulsory". The aforementioned triad is recommended to be supplemented by the notion "necessarily". The necessary actions should include actions related to the risk of losing freedom, health, and sometimes even death, in connection with forced or involuntary acts to carry out moral duty, order, law. Such actions are often endowed with a higher status in the hierarchy of official actions, are considered to be granted the highest degree of moral approval and, even, admiration. At the same time, those who carry out the necessarily actions, as a rule, perceive their actions as just the performance of official duty. Therefore, the commission of actions related to professional risk becomes a duty only because of the special self-consciousness inherent in the military and law enforcement officers.The higher education institutions with specific educational conditions should be aimed at improving the system of moral education of security officers, the comprehensive involvement of the latest ideas, methods and means of modern pedagogy, based on the deontological potential of the competent approach in the professional training system.The process of the risk-oriented thinking formation for future employees of security organs should be carried out subject to the use of the modern legal and regulatory framework on safety and health of the European Union, which will enhance their competitiveness in the modern labor market.Keywords: higher education institutions with specific educational conditions, employees of security structures, risk-oriented approach, risk-oriented thinking.
Botanik Bahçesinin Öğretim Sürecinde Öğrencilerin Sosyobilimsel Konulara Olan Bakışlarına Etkisi: Sürdürülebilir Çevre
Authors: KARSLI Gülsün , KARAMUSTAFAOĞLU Orhan , KURT Murat
Published: November 2019

Araştırmanın amacı 5. sınıf fen bilimleri
dersinde kullanılabilecek Sürdürülebilir Çevre konusunda örnek bir okul dışı
öğrenme ortamı uygulaması tasarlamak, yürütmek ve öğrenciler üzerindeki
yansımalarını incelemektir. Nitel araştırma yöntemlerinden durum çalışması
kullanılmıştır. Araştırma 2018-2019 Eğitim Öğretim yılı 2. döneminde Ağrı ili
Merkez ilçesinde bir ortaokulda öğrenim görmekte olan 5. sınıf 32 öğrenci ile
yürütülmüştür. Çalışmada 2018 Fen Bilimleri Öğretim Programında bulunan 5.
sınıf “İnsan ve Çevre” ünitesine ait kazanımlara göre etkinlikler
hazırlanmıştır. Okul dışı öğrenme ortamlarından biri olan Ata Botanik Bahçesine
gezi düzenlenmiştir. Sürdürülebilir çevre ölçeği ön test ve son test olarak
uygulanmış, son test lehine istatiksel anlamda farklılık bulunmuştur. Botanik
bahçesine yapılan gezinin öğrencilerin çevre bilincini artırmada etkili olduğu
tespit edilmiştir.
Fen Bilgisi Öğretmen Adaylarının Mesleki Benlik Saygıları İle Yaşam Doyumlarının İncelenmesi
Authors: AKTAÇ Volkan , ÇETİNKAYA Murat
Published: November 2019

Bu araştırmada, fen bilgisi öğretmen adaylarının
mesleki benlik saygıları ile yaşam doyumlarının çeşitli değişkenler açısından
incelenmesi ve aralarındaki ilişki düzeylerinin belirlenmesi amaçlanmıştır.
Araştırma verileri, Ordu Üniversitesi Fen Bilgisi Öğretmenliği Bölümünde
öğrenim gören 66 öğretmen adayından elde edilmiştir. İlişkisel tarama
yönteminin kullanıldığı araştırmada veri toplama aracı olarak; “Mesleki
Benlik Saygısı Ölçeği”, “Yaşam Doyum Ölçeği” ile araştırmacı tarafından
oluşturulan “Kişisel Bilgi Formu” kullanılmıştır. Araştırmada fen bilgisi
öğretmen adaylarının “Mesleki Benlik Saygısı” ile “Yaşam Doyumu” değişkenleri
arasındaki ilişki düzeyi, basit doğrusal regresyon analizi ve pearson
korelasyon analiziyle incelenmiştir. Araştırma sonuçları değerlendirildiğinde
mesleki benlik saygısı ile yaşam doyumu arasında pozitif yönde istatistiksel
olarak anlamlı bir ilişki bulunmuştur.
Estudio de un sistema de mantenimiento centrado en la conï€abilidad para aumentar la disponibilidad de los motores asÃ­ncronos trifÃ¡sicos de la empresa Cogorno S. A. - Trujillo.
Authors: Idrogo Cruzado Wilmer Francisco
Published: November 2019

El presente estudio estÃ¡ dirigido a las empresas que cuenten con mÃ¡quinas industriales que son accionadas por motores elÃ©ctricos asÃ­ncronos trifÃ¡sicos de tipo jaula de ardilla o rotor de bobinado. El objetivo del presente artÃ­culo es mejorar el funcionamiento y ciclo de vida de dichos motores. Esta investigaciÃ³n se basa principalmente en la aplicaciÃ³n de un sistema de mantenimiento centrado en la conï€abilidad RCM, en la planta de procesos tÃ©rmicos de la empresa Cogorno S.A Trujillo, teniendo como ï€nalidad: A travÃ©s de la metodologÃ­a del AMEF (anÃ¡lisis de modos y efectos de falla) y con el desarrollo del anÃ¡lisis de criticidad elaborar un programa de actividades de mantenimiento a los elementos crÃ­ticos y semicriticos de los motores tipo rotor de bobinado y jaula ardilla; y , de este modo aumentar la disponibilidad, conï€abilidad, reducir la mantenibilidad , costos de producciÃ³n , mantenimiento y las paradas no planeadas.
Sistema informÃ¡tico odontolÃ³gico vÃ­a web para mejorar el servicio de atenciÃ³n a los pacientes en la ClÃ­nica San MartÃ­n de la ciudad de Trujillo
Authors: Cueva Chuquijajas Wagner Enrique
Published: November 2019

La presente investigaciÃ³n realizada en el centro OdontolÃ³gico â€œSan MartÃ­nâ€ su objetivo general es mejorar el servicio de atenciÃ³n de los pacientes concurrentes a la ClÃ­nica odontolÃ³gica San MartÃ­n de Trujillo, se propuso utilizar un sistema InformÃ¡tico vÃ­a web, para el mejoramiento de la atenciÃ³n paciente. El tipo investigaciÃ³n es aplicado, pre- experimental. Para la conï€abilidad se utilizÃ³ pre-test post-test con un nivel de 95% conï€anza. UtilizÃ¡ndose como mÃ©todos de anÃ¡lisis de datos Z para las medidas de tiempos correspondientes. Se utilizÃ³ la metodologÃ­a Iconix para el desarrollo del sistema informÃ¡tico odontolÃ³gico, puesto que se sometiÃ³ a selecciÃ³n y se comprobÃ³ que es la mÃ¡s aceptable para el logro de la presente investigaciÃ³n. La muestra obtenida es de 270 pacientes atendidos durante el mes. En el primer indicador se obtuvieron resultados satisfactorios ya que el tiempo promedio en la reserva de citas a los pacientes se ha reducido en 235.72 segundos. Que representa un 79.35 % del tiempo total, en el segundo indicador el tiempo promedio en el registro de los historiales de atenciÃ³n al paciente disminuye 139.34 segundos, que representa el 66.54%. y por Ãºltimo con respecto al Tiempo Promedio en la bÃºsqueda de historial clÃ­nico con el Sistema Actual es de 297.02 segundos, en comparaciÃ³n al Sistema Propuesto que es 74.60 segundos, lo que determina una reducciÃ³n de tiempo de 222.42 segundos; lo cual permitirÃ¡ una reducciÃ³n del 74.88% en la bÃºsqueda de las historias clÃ­nicas.

Palabras clave: Sistema informÃ¡tico odontolÃ³gico, vÃ­a web, reserva de citas.
Efficacy of sequential therapy versus standard triple therapy versus quinolone-based triple therapy for eradication of Helicobacter pylori infection
Authors: Sehgal Rishabh , Singh Harsimranjit , Singh Inderpal , Mittal Jyotisterna , Kaur Kanwerpreet
Published: November 2019

Background: Helicobacter pylori colonization is a risk factor for Adenocarcinomas of the distal (noncardia) stomach. The presence of Helicobacter pylori is strongly associated with primary gastric lymphoma. The urea breath test, the stool antigen test, and biopsy-based tests can all be used to assess the success of treatment. Helicobacter pylori is susceptible to a wide range of antibiotics in vitro, monotherapy is not usually successful, probably because of inadequate antibiotic delivery to the colonization niche. Current regimens consist of a PPI or H2 blocker, bismuth citrate and two or three antimicrobial agents given for 7-14 days. Research on optimizing drug combinations to increase efficacy continues. Efficacy of Sequential Therapy versus Standard Triple Therapy versus Quinolone-based Triple Therapy for eradication of Helicobacter pylori infection is done in this study.Methods: This study had been conducted on 150 patients divided into three groups randomly 50 Patients each and were treated with Sequential, Standard and Quinolone based triple therapy respectively. Patients were followed up no sooner than four weeks of completing therapy by rapid urease test to confirm eradication.Results: There was no significant difference with regards to presence of GERD, Gastric Ulcers, Duodenal Ulcers (p value>0.05) except for presence of erosive gastritis which was significantly higher in patients in quinolone group (p value<0.05). The eradication rate was 90%, 86%, 82% in Sequential therapy group, Triple therapy group and Fluroquinolone group respectively. However, there was no statistically significant difference in eradication rates in these groups (p value>0.05).Conclusions: Sequential therapy group had better eradication rates (90%) as compared to standard triple therapy group (86%) and fluroquinolone therapy group (82%) but results were not statistically significant when all three groups were compared together.
Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster.
Authors: Zurawa-Janicka Dorota , Kobiela Jaroslaw , Stefaniak Tomasz , Wozniak Agnieszka , Narkiewicz Joanna , Wozniak Michał , Limon Janusz , Lipinska Barbara
Published: November 2019

Serine proteases HtrA1 and HtrA2 are involved in cellular stress response and development of several diseases, including cancer. Our aim was to examine the involvement of the HtrA proteins in acute oxidative stress response induced in hamster kidney by estrogen treatment, and in nephrocarcinogenesis caused by prolonged estrogenization of male Syrian hamster. We used semi-quantitative RT-PCR to estimate the HtrA1 and HtrA2 mRNA levels in kidney tissues, and Western blotting to monitor the amount of the HtrA proteins. Within the first five hours following estrogen administration both HtrA1 mRNA and the protein levels were increased significantly. No changes in the expression of HtrA2 were observed. This indicates that HtrA1 may be involved in the response against oxidative stress induced by estrogen treatment in hamster kidney. During prolonged estrogenization, a significant reduction of the HtrA1 mRNA and protein levels was observed after 6 months of estradiol treatment, while the expression of HtrA2 was significantly elevated starting from the third month. This suggests an involvement of the HtrA proteins in estrogen-induced nephrocarcinogenesis in hamster. Using fluorescence in situ hybridization we localized the HtrA1 gene at the qb3-4 region of Syrian hamster chromosome 2, the region known to undergo a nonrandom deletion upon prolonged estrogenization. It is possible that the reduced level of HtrA1 expression is due to this chromosomal aberration. A full-length cDNA sequence of the hamster HtrA1 gene was obtained. It codes for a 50 kDa protein which has 98 and 96% identity with mouse and human counterparts, respectively.
Comparison of Ten-Day Sequential and Standard Triple Therapy for Helicobacter pylori Eradication
Authors: Ravarian Behdad , Esmaeilzadeh Abbas , Saeedi Sandra , Moghbeli Meysam , Ganji Azita
Published: November 2019

- Helicobacter pylori (HBP) is reported as one of the main causes of peptic ulcer disease (PUD) and gastric cancer in the world. The challenge for finding an optimal treatment regimen for HBP eradication is still a matter of concern. The aim of this study was to compare the HBP eradication rate as well as side effects between two 10-days treatments of the standard triple and sequential regimen. This study was performed on patients with dyspepsia and HBP positive. Patients were categorized in two treatment groups including; standard (Omeprazole, Amoxicillin, and Clarithromycin) and sequential treatment (Omeprazole, Amoxicillin, Clarithromycin, and Metronidazole). HBP eradication rate, side effects, and treatment costs were compared between two groups. One hundred thirty-two patients (58 males, 74 females) with a mean age of 42.7±14.2-year-old were studied in two groups of Standard Treatment (n=66) and Sequential Treatment (n=66). There were not any significant differences between two groups regarding baseline features. The overall rate of HBP eradication was estimated to be 79.5%. Although, there was not any significant difference between the observed side effects, the mean cost of treatment in standard was significantly lower than that in the sequential group (P=0.001). It seems that there are not any clinical differences between 10-day treatment plan of the standard triple and sequential therapy in the case of HBP eradication and side effects. However, the sequential treatment might be a better option as the economic point of view.
© 2019 Tehran University of Medical Sciences. All rights reserved.
Acta Med Iran 2019;57(4):224-228.
Psychological Consequences of Breast Cancer in Iran: A Meta-Analysis
Authors: REFAEE SAEEDI Nasrin , AGHAMOHAMMADIAN SHARBAF Hamidreza , ASGHARI EBRAHIMABAD Mohammad Javad , KARESHKI Hossein
Published: November 2019

Background: Breast cancer is known as one of the most common cancers among women and has severe psychological effects. This study aimed to identify the psychological consequences of breast cancer in previous studies based on meta-analysis.
Methods: Meta-analytic procedures were conducted by Prisma guidelines. A literature search was conducted by using following electronic databases including scientific information databases (SID), Magiran, Medlib, ScienceDirect, PubMed, Google Scholar, Web of Science, Scopus, CINAHL and Medline from 1991 through 2017 regarding the psychological consequences associated with breast cancer in Iran. The content of all articles was evaluated by the Prisma checklist and analyzed meta-analysis in CMA software.
Results: The final synthesis was carried out on 56 quantitative studies. Considering the findings of meta-analysis of the psychological consequences of patients with breast cancer in seven classes, anxiety (ES=-0.76), body image (ES=0.199), coping strategies (ES= 0.214), depression (ES=-0.700), fatigue (ES=0.322), quality of life (ES= 0.428), and sexual function (ES=0.355) were achieved.
Conclusion: Based on the results of the high level of psychological consequences of breast cancer in women with breast cancer, it is necessary to formulate appropriate therapeutic protocols in order to adjust the psychological consequences.
The Current State of MPOWER Policies in the Republic of Kazakhstan: Data from the Global Adult Tobacco Survey 2014
Authors: ABDRAKHMANOVA Shynar , KERUYENOVA Zarina
Published: November 2019

Background: The Global Adult Tobacco Survey (GATS) is a global study to monitor tobacco use, and evaluate current measures and requisite policies on tobacco control. In this study, the key indicators from GATS Kazakhstan that address six tobacco control policies are assessed.
Methods: GATS Kazakhstan was a nationally representative household survey of the adult population aged 15 yr or older (n=4425, 52.8% females) implemented in 2014, in all regions of Kazakhstan. A multi-stage, geographically clustered sample design was used to obtain the key indicators of tobacco use and tobacco measures in the country. The sampling weights were employed to ensure real national representation. A household and individual questionnaire were administered through electronic devices.
Results: The majority of current tobacco users were cigarette smokers 22.2%. Overall, 19.0% of adults were exposed to secondhand smoke while at work. One third of smokers made a quit attempt in the last 12 months. Only, 74.0% of adults believed that breathing other people’s smoke causes serious illness in non-smokers. Almost all current smokers (97.6%) noticed pictorial health warnings on cigarette packages. Over half (58.0%) of the current smokers had thought about quitting, having seen pictorial warning labels. Exposure to any cigarette advertisement, sponsorship or promotion had been experienced by 25.7% of adults, with the highest rate of noticing cigarette advertisements being found in stores where cigarettes are sold (14.0%). Cigarettes were largely affordable for the population.
Conclusion: The GATS Kazakhstan results identified tobacco use indicators, as well as existing gaps in tobacco control measures.
Serum Concentration of Thyroid Hormones Long-Term After Sulfur Mustard Exposure
Authors: MOAIEDMOHSENI Sakine , GHAZANFARI Tooba , MIRSHARIF Ensie Sadat , ASKARI Nayere , MOHAMMAD HASSAN Zuhair , NAGHIZADEH Mohammad Mehdi , FAGHIHZADEH Soghrat , AZIZI Fereidoun
Published: November 2019

Background: Despite several reports on the clinical manifestations of sulfur mustard (SM) intoxication, there is no study on serum concentrations of thyroid hormones long-term after SM exposure. In this study, the changes in thyroid functioning parameters 20 yr after SM exposure were evaluated.
Methods: This study is a part of a larger historical cohort study conducted in 2007 following 20 years of the exposure to SM, called Sardasht–Iran cohort study (SICS). We (SICS) comprised an SM–exposed group from Sardasht City, West Azerbaijan Province, Iran (n=169 as hospitalized group and n=203 as non-hospitalized exposed group); and control participants were selected from Rabat, a town near Sardasht (n=126). Peripheral blood samples were taken in fasting state and then the sera were separated. T4, T3, TSH, antithyroglobulin (anti–Tg), and antithyroid peroxidase (anti–TPO) concentrations in the sera were measured by the ELISA method.
Results: The mean of T3 concentration was significantly higher in the exposed than control group (0.88 ± 0.26 nmol/L vs 0.8 ± 0.25 nmol/L, P<0.001). The levels of TSH, T4, and T3up were not significantly different between the exposed and control groups. Thyroglobulin level was significantly higher in the exposed non-hospitalized group (56.07 ± 140.22 µg/L vs 17.66 ± 41.49 µg/L, P=0.004), but the level of anti–Tg and anti–TPO showed no significant differences between the two groups.
Conclusion: More studies are needed on the alterations in thyroid hormones, their gene expressions, and mechanisms involved in SM exposure to clarify the causes of these alterations.
Öğretmen Adaylarının “AIDS” Kavramı Konusundaki Bilişsel Yapıları: Çizme-Yazma Tekniği Örneği
Authors: EKİCİ Gülay
Published: November 2019

Bu
araştırmada öğretmen adaylarının AIDS kavramı konusundaki bilişsel yapıları
nasıldır? sorusuna cevap aranmıştır. Çalışmada nitel araştırma modeli kapsamında
durum çalışması deseni kullanılmıştır. Çalışmaya farklı branşlardan 298
öğretmen adayı katılmıştır. Veriler çizme-yazma tekniğiyle  toplanmıştır. Elde edilen verilerin
analizinde içerik analizinin kullanımı tercih edilmiş olup veriler kategorilere
göre yorumlanmıştır. Katılımcıların AIDS kavramı hakkındaki bilişsel
yapılarının yoğunlaştığı kategorilerin “AIDS’in sonuçları, AIDS’in taşıyıcıları ve AIDS’in
bulaşma yolları” kategorileri olduğu
belirlenmiştir. Araştırmanın önemli sonuçlardan biri ise belirlenmiş olan tüm
kategorilerde katılımcıların AIDS kavramıyla ilgili farklı kavramlara sahip
oldukları ve bilişsel yapılarının yeterli düzeyde olmadığı tespit edilmiştir.
Çünkü katılımcıların %67.91’inin temsili
olmayan-karikatür çizimler yaptıkları görülmüştür. Katılımcılar kategorilerde en fazla Ölüm, Mutsuz insanlar, Erkek, Kadın gibi kavramlara ait çizimler
yaptıkları belirlenmiştir.
Üniversite Öğrencilerinde Olumlu Düşünme Becerisinin Kişilerarası İletişim Becerisi ile İlişkisi
Authors: KARADAĞ Şule
Published: November 2019

Bu çalışma üniversite
öğrencilerinin olumlu düşünme becerileri ile kişilerarası iletişim becerileri
arasındaki ilişkiyi ortaya koymak amacı ile planlanmıştır. Kesitsel ve
değişkenler arasındaki ilişkileri belirlemek amacıyla ilişki arayıcı –
tanımlayıcıtasarım kullanılmıştır. Çalışmada olumlu düşünme becerileri ölçeği
ile kişilerarası iletişim becerisi ölçekleri kullanılmıştır. Analizleri
sonucundakatılımcıların %67,6’sı (n=275) kadın, %32,4’ü (n=132) erkektir ve olumlu
düşünme becerisi toplam puan x̄=15,36±4,44, kişilerarası iletişim becerisi toplam puan x̄=99,10±12,66
olarak tespit edilmiştir. Çalışmanın sonucunda, olumlu düşünme becerisi
ile cinsiyet arasında anlamlı ilişki görülmüştür (p<0.05). Aynı şekilde
olumlu düşünme becerileri ile kişilerarası iletişim toplam puan ve alt
faktörleri (iletişim ilkeleri ve temel becerileri, kendini ifade etme, etkin
dinleme ve sözel olmayan iletişim ve iletişim kurmaya isteklilik) arasında da anlamlı
bir ilişki saptanmıştır.
Göstergebilimsel Metin Çözümlemeye Dayalı Etkinliklerin Ortaokul Öğrencilerinin Hikâye Çözümleme Becerilerine Etkisi
Authors: CİN ŞEKER Zeynep
Published: November 2019

Bu
çalışmada etkinliklere dayalı göstergebilimsel metin çözümleme yönteminin
ortaokul 7. sınıf öğrencilerinin hikâye çözümleme becerilerine etkisi
araştırılmıştır. Araştırmanın modeli öntest-sontest kontrol gruplu yarı
deneysel desendir Araştırmanın
çalışma grubu ise amaçlı örnekleme yöntemlerinden olan aykırı durum örneklemesi
ile belirlenmiştir. Bu doğrultuda 2014-2015 eğitim öğretim yılı TEOG başarı
sıralaması dikkate alınarak Erzurum il merkezindeki yüksek dereceli bir
ortaokul (O1) ile düşük dereceli bir ortaokuldaki (O2) 97
öğrenci çalışmaya katılmıştır. Araştırmacı bizzat belirlenen okullara giderek
“Hikaye Çözümleme Formu” aracılığıyla verileri elde etmiştir. Veriler, Bağımsız
ve Bağımlı Örneklemler için t-Testi kullanılarak analiz edilmiştir. Elde edilen
bulgular doğrultusunda göstergebilimsel metin çözümleme yöntemi esas alınarak
hazırlanan etkinliklerin, öğrencilerin hikâye çözümleme başarılarını artırdığı
sonucuna ulaşılmıştır.
O immersyjności escape roomów. Przykład pokoi Tick Tack w Gliwicach
Authors: Julke-Bogacka Katarzyna
Published: November 2019

Escape room (ER) to rodzaj kooperacyjnej gry rozgrywanej na żywo. Polega na znalezieniu w określonym czasie wyjścia z zamkniętego pomieszczenia lub wykonaniu innego, dodatkowego celu misji poprzez rozwiązanie serii zagadek i łamigłówek. Dotychczas niewiele prac zostało poświęconych ER, szczególnie w środowisku polskich badaczy gier. Niniejszy artykuł jest próbą wypełnienia tej luki. W tekście przedstawiono krótką historię powstania ER oraz postawiono tezę, że przyczyną sukcesu i popularności wybranych ER jest immersyjność. Zagadnienie immersyjności ER oraz warunki, jakie powinien spełnić dany pokój, aby w pełni zaangażować graczy, omówiono na przykładzie pokoi firmy Tick Tack z Gliwic. Analizę przeprowadzono na podstawie literatury źródłowej oraz własnych doświadczeń z gry.
Sociocultural Aspects of Leadership: A Look at Gender Roles
Authors: Druzhinin Viktor Ivanovich , Sabirov Askadula Galimzyanovich , Krivosheev Sergey Anatolyevich , Shagivaleeva Guzalia
Published: November 2019

The research aims to examine specifically the gendered aspects of professional and management leadership and evaluate the prospects for overcoming gender inequality in the social sphere. The study involved 350 students comprising of 45% men and 55% women from three different universities of Kazan (Russia): Kazan Federal University, Kazan Federal Agricultural University, and Kazan State Medical University. To accomplish the research objectives, empirical data were gathered using the Bem Sex-Role Inventory and a Sex Typing on Leadership Survey composed by Cann and Siegfried (1990). The findings reveal that only 12% of students were raised in traditional patriarchal families, while the rest was raised in a multicultural environment. The gender-neutral type of leadership is dominant in student groups. This observation suggests a definite trend towards gender equality in management.
Sexual Harassment of Women at Workplace in Assam: The Present Scenario
Authors: Vauquline Polly
Published: November 2019

The United Nations General Assembly has delegated 25 November as the International Day for the Elimination of Violence Against Women (VAW). This issue of the journal Space and Culture, India is dedicated to raise further awareness against VAW, inequalities and discrimination. Now I turn to discuss the abstract of this editorial.
Greater access to public spaces, entry into the professional space and engagement in different sectors of labour forces are the diverse forms of opportunities urbanisation and modernisation is supposed to provide to each individual including women. However, one could argue that both urbanisation and modernisation have begeted gender discrimination. And the degree of discrimination is faced mostly by women putting them in a vulnerable position by generating women-centric workplace violence—mainly sexual harassment of women at workplace (SHWWP). This paper highlights the findings of two research studies: Workplace Safety and Dignity for Women in Assam and Prevention, Prohibition and Redressal of Sexual Harassment at Professional Places in Assam: Post 23rd April 2013 carried out by the author during the period 2017-2019.
According to the National Crime Records Bureau (NCRB), 2017, the state of Assam contributes 6.4 percentage points of state-share to all-India share of crime against women; its overall crime rate against women when calculated as a crime per one-hundred thousand of the population stands at 143.6. Evidently, the state of Assam also has high occurrences of SHWWP, which stands at 44% but only 2.7% complaint cases were lodged. The findings also uncovered that there exist weak and inadequate complaint mechanisms in the state even after the existence of Sexual Harassment of Women at Workplace (Prevention, Prohibition and Redressal) Act, 2013.
Psychological Wellbeing of Adolescents Gifted in Math, Humanities and Sports: Comparative Analysis
Authors: Volkova Elena , Miklyaeva Anastasia , Volkova Irina , Bezgodova Svetlana
Published: November 2019

Current article presents the study of psychological wellbeing of adolescents (n=168, age 15-17) gifted in math, humanities and sports and educated in advanced programs for gifted children. Theoretical framework of this study is eudemonic concept of psychological wellbeing by C. Ryff. Psychological wellbeing is measured with Ryff wellbeing scales in Russian adaptation by L.V. Zhukovskaya and E.G. Troshikhina. The study is aimed at understanding differences in psychological wellbeing of gifted teenagers connected to gender and type of giftedness. The results suggest that general wellbeing score did not differ for adolescents with different types of giftedness or of different genders. Separate components of psychological wellbeing, such as purpose in life and self-acceptance, are influenced by activity connected to the talent. Gender differences are subjected to age-specific trends of personal development in adolescence. Type of giftedness might reinforce these trends.
Odorants and Their Contributions to Overall Odour Emission from a Landfill Leachate
Authors: Wang Xinguang , Parcsi Gavin , Sivret Eric , Le Minh , Stuetz Richard
Published: November 2019

As one of the important odour sources, landfill sites have drawn more and more public attentions. Odour emissions from landfill sites depend on the waste buried, operation activities, running conditions, etc. A study for finding out all possible odorous compounds from a landfill was conducted by analysing of on-site gas phase samples and emission samples from a landfill leachate in Sydney, Australia using thermal desorber – gas chromatography – mass spectrometer (TD-GC-MS) and air server – thermal desorber – gas chromatography – sulfur chemiluminoscence detector (AS-TD-GC-SCD). 49 odorants were identified from emission gas samples collected from landfill leachate collection pipe and only 8 odorants were detected from flux hood emission samples of the collected leachate sample. This indicates that more sampling and measurement techniques are always better to acquire all possible pollutants from an unknown odour source. The contributions of these odorants to overall odour emissions were also calculated based on their concentrations and odour thresholds. The top 10 odorants from leachate transportation pipe include methyl mercaptan, ethyl mercaptan, m-xylene, H2S, CS2, 1,2,3,4-tetra-methylbenzene, p-xylene, 1,2,4-trimethylbenzene, ethylbenzene and α-pinene. They contributed more than 95% to the odour in the gas accumulated in the leachate collection pipe.
Learning Dispositif and Emotional Attachment: A Preliminary International Analysis
Authors: Huston Simon , Huston Elena , Kozlowski Marek
Published: November 2019

This research investigated the significance of learning dispositif (LD) and emotional attachment (EA) on perceived learning success (LS) across a diaspora of Western, Russian, Asian, Middle Eastern and Chinese student cohorts. Foucault’s LD captures the disparate socio-cultural contexts, institutional milieus and more or less didactic teaching styles that moderate learning. EA is a multi-dimensional notion involving affective bonds that emerged in child psychology and spread to marketing and other fields. The sequential explanatory research reviewed the learning and EA literatures and generated an LD–EA framework to structure the quantitative phase of its mixed investigations. In 2017 and 2018, the research collected 150 responses and used a range of statistical techniques for quantitative analysis. It found that LS varied significantly across cohorts, intimating that dispositifs influence learning. Nonparametric analysis suggested that EA also influenced learning, but regressions were inconclusive. Exploratory techniques hint at a dynamic mix of emotional or cognitive motivations during the student learning journey, involving structural breaks in student/instructor relationships. Cluster analysis identified distinct student groupings, linked to years of learning. Separately, qualitative analysis of open-ended survey questions and expert interviews intimates that frequent teacher interactions can increase EA. The synthesis of quantitative with qualitative results and pedagogical reflection suggests that LD and EA both influence learning in a complex, dynamic system. The key constituents for EA are Affection, Connection, Social Presence (SP), Teaching Presence (TP) and Flow but student emotional engagement is conditioned by the socio-cultural milieu (LD) and associated factors like relationships and trust. Unlike in the Community of Learning framework, in the EA framework Cognitive Presence (CP) is an outcome of the interaction between these EA constituents, associated factors and the socio-cultural milieu. Finally, whilst awareness of culture and emotions is a useful pedagogical consideration, learning mainstays remain inclusive educational systems that identify student needs and support well-designed programmes. Within these, scaffolded modules should include a variety of engaging learning activities with non-threatening formative and trustworthy summative feedback. We acknowledge some statistical study limitations, but its tentative findings make a useful preliminary contribution
Preprint: Piloting Close-Range Remote Sensing of Endangered Borneo Pygmy Elephants Using Photographs Ecotourists Share via Social Media
Authors: Walker Obelia , Daymond Tahlia , Chan Jennifer K.L. , Teo Albert C.K. , Newsome David , Simpson Greg D.
Published: November 2019

This pilot study explores the potential of using a citizen science approach for sourcing volunteered geographic information via social media to research wildlife tourism interactions with endangered Borneo Pygmy Elephants on the lower Kinabatangan River in Sabah, Malaysia. Such information is critical if the lower Kinabatangan region is to achieve the United Nations Sustainable Development Goals through a sustainable tourism industry based around viewing the pygmy elephants. Guests and guides from the Sukau Rainforest Lodge were encouraged to become close-range remote sensors by sharing geotagged photographs of pygmy elephant sightings on Flickr. A ten week on-ground trail generated 247 photographs shared by 17 individual contributors with approximately two-thirds (65%) of photographs being georeferenced for the time and location of the elephant sighting. Plotting those sighting to explore the vegetation matrix (i.e. remnant forest or oil palm plantation) showed almost three-quarter (73%) of the sightings occurred within 1 km of an oil palm plantation. Of greater concern is that one in two sightings (50%) along the river occurred within the 500 m of an oil palm planation, which is inside the riparian buffer that the Sabah Government recommended for conservation of the elephants in their Lower Kinabatangan range. This study therefore demonstrates proof of concept for this research method and its further application at the nexus of wildlife conservation and sustainable ecotourism research.
A Hierarchical Machine Learning Model to Discover Gleason Grade Group-specific Biomarkers in Prostate Cancer
Authors: Hamzeh Osama , Alkhateeb Abedalrhman , Zheng Julia , Kandalam Srinath , Lueng Crystal , Aikukke Govindaraja , Cavallo-Medved Dora , Palanisamy Nallasivam , Rueda Luis
Published: November 2019

1) Background: One of the most common cancer that affects men worldwide and North American men is prostate cancer. Gleason score is a pathological grading system to examine the potential aggressiveness of the disease in the prostate tissue. The advancement in computing and next-generation sequencing technology now allow us to study the genomic profiles of patients in association with their different Gleason score more accurately and effectively. 2) Methods: In this study, we used a novel machine learning method to analyze gene expression of prostate tumors with different Gleason scores, and identify potential genetic biomarkers for each Gleason group. We obtained a publicly-available RNA-Seq dataset of a cohort of 104 prostate cancer patients from the National Center for Biotechnology Information’s (NCBI) Gene Expression Omnibus (GEO) repository, and categorized patients based on their Gleason scores to create a hierarchy of disease progression. A hierarchical model with standard classifiers in different Gleason groups, also known as nodes, was developed to identify and predict nodes based on their mRNA or gene expression. In each node, patient samples were analyzed via class imbalance and hybrid feature selection techniques to build the prediction model. The outcome from analysis of each node is a set of genes that can differentiate each Gleason group from the remaining groups. To validate the proposed method, the set of identified genes are used to classify a second dataset of 499 prostate cancer patients collected from cBioportal [1]. 3) Results: The overall accuracy of applying this novel method to the first dataset was 93.3%, and further validated to 87% accuracy using the second dataset. This method also identified genes that were not previously reported as potential biomarkers for specific Gleason groups. In particular, PIAS3 was identified as a potential biomarker for Gleason score 4+3=7, and UBE2V2 for Gleason score 6. 4) Insight: Previous reports show that the genes predicted by this newly proposed method strongly correlate with prostate cancer development and progression. Furthermore, pathway analysis shows that both PIAS3 and UBE2V2 share similar protein interaction pathways, the JAK/STAT signaling process.
KERJA SAMA DI ANTARA SDM PERPUSTAKAAN UNTUK MENUJU LAYANAN PRIMA DAN UNGGUL
Authors: Fatmawati Endang
Published: November 2019

Internal problems among the human resources in each library must exist. To achieve service excellence and superior library requires cooperation. Cooperation among individuals there is a need of every library. Solid team work is the key to success in managing the library. The practice of cooperation among individuals in the library can be assessed based on aspects of social relations and the exchange of knowledge.

Keywords: team work, cooperation, human resources, library
Influência dos cultivos de milho e guandu para produção de silagem na resistência do solo à penetração
Authors: Nogueira Guimarães I.C. , De Faria Theodoro G. , Bueno Yamashita N.Y. , De Oliveira Golin H. , Padilha Rezende R.
Published: November 2019

O uso intensivo de máquinas agrícolas no cultivo de plantas para produção de silagem pode ocasionar a compactação do solo e comprometer o desenvolvimento das plantas. O objetivo deste trabalho foi avaliar os efeitos do cultivo de milho e guandu na resistência do solo à penetração (RP), cultivados em solo preparado de forma convencional. Os dados de RP foram obtidos por meio de um penetrômetro de impacto modelo IAA/Planalsucar, até os 0,4 m de profundidade. Foram coletadas amostras de solo para se avaliar a umidade gravimétrica do solo. Os valores de resistência mecânica do solo à penetração foram transformados em unidade padrão de pressão (MPa). O delineamento experimental empregado foi de blocos ao acaso, com dois tratamentos representados pelos cultivos de milho e guandu em área de 2000 m² cada, divididos em 10 repetições e 4 perfis analisados em cada repetição. Os valores encontrados nos dois tratamentos foram críticos ao desenvolvimento vegetal e o solo cultivado com guandu apresentou menor resistência à penetração em quase todos os estratos analisados. Os resultados obtidos demonstraram que o potencial do guandu em descompactar o solo foi superior ao do milho.
NEW SOURCES OF GROWTH: THE ROLE OF FRUGAL INNOVATION AND TRANSFORMATIONAL LEADERSHIP
Authors: Juhro Solikin M. , Aulia A. Farid
Published: November 2019

This paper’s main thesis is that frugal innovation and transformational leadership offeradditional sources of growth. Our main contribution is the proposal of what we referto as the breakthrough possibility frontier (BPF) model, which integrates two aspectsof leadership: innovation quality (frugal innovation) and leadership competency(transformational leadership). We test the BPF model on two groups of respondents,one group consisting of university students who had never been formal leadersand the other formal leaders who had office experience. The BPF analysis suggeststhat transformational leadership is a game changer, required for breakthroughs.Transformational leadership is key to encouraging innovation quality and leadershipcompetency and, we argue, to facilitating new sources of growth. Our results implythe development of an integrated institutional framework for innovation. We believethat innovative leadership development programs that can be easily implementedand replicated in other regions are needed to develop transformational leadershipcompetencies.