bluuebunny/crossref_metadata_2025 huggingface dataset:
Growth And Lipid Accumulation of Chaetoceros calcitrans After Phosphorus And Light Intensity Optimization
Authors: Hasby Rizal Maulana , Syarifah Ismi Farah , Taufiqurrohman Opik
Published: January 2024

AbstractGrowth and lipid content of Chaetoceros calcitrans are greatly influenced by environmental factors. The aims of this study to optimize phosphorus concentrations and light intensity on the growth and lipid accumulation of C. calcitrans. This study used N:P:light intensity concentration from the previous research, namely 441:36.2 µM:2,500 lux (12:1:2,500 lux). Concentrations of P were then optimized to 36.2 µM, 27.5 µM, 18.1 µM, 9.05 µM (1; 0.75; 0.5; 0.25) and light intensity to 2,500; 3,000; 3,500; 4,000 lux. C. calcitrans was cultured in medium f/2 guillard, the initial density was 6 x 105 cells/mL. Sampling for lipid analysis was conducted in exponential, stationary, and the end of stationary phase by centrifugation, whereas lipid was extracted using the Bligh and Dyer method, and dried lipids were analyzed using gas chromatography-GC. The highest lipid content found at the late stationary phase of the N:P concentrations and light intensity 12:0.5:(4,000 lux), there was 15.46 ± 0.53%-dw with the highest cell density of 5.5 ± 5.56 x 106 cells/mL. The analysis result showed that palmitoleic acid (C16:1) was the highest fatty acid produced by each optimization. Nutritional deficiency and high light intensity were triggers for of C. calcitrans to accumulate lipids, and influence the fatty acid profile of C. calcitrans.AbstrakPertumbuhan dan kandungan lipid Chaetoceros calcitrans sangat dipengaruhi oleh faktor lingkungan. Tujuan penelitian ini adalah untuk mengoptimasi konsentrasi fosfor dan intensitas cahaya terhadap pertumbuhan dan akumulasi lipid C. calcitrans. Penelitian ini menggunakan hasil konsentrasi N:P:intensitas cahaya dari penelitian sebelumnya, yaitu 441:36.2µM:2,500 lux (12:1:2,500 lux). Konsentrasi P kemudian dioptimasi menjadi 36,2 µM, 27,5 µM, 18,1 µM, 9,05 µM (1; 0,75; 0,5; 0,25), dan intensitas cahaya menjadi 2.500; 3.000; 3.500; 4.000 lux. C. calcitrans dikultur dalam medium f/2 guilard, densitas awal 6 x 105 sel/mL. Pengambilan sampel untuk analisis lipid dilakukan pada fase eksponensial, stasioner, dan akhir stasioner dengan sentrifugasi, sedangkan lipid diekstraksi menggunakan metode Bligh dan Dyer, lipid kering dianalisis menggunakan kromatografi gas-GC. Kandungan lipid tertinggi terdapat pada fase akhir stasioner konsentrasi N:P dan intensitas cahaya 12:0,5:(4,000 lux), yaitu sebesar 15,46 ± 0,53%-dw dengan kerapatan sel tertinggi 5,5 ± 5,56 x 106 sel/mL. Hasil analisis menunjukkan bahwa asam palmitoleat (C16:1) merupakan asam lemak tertinggi yang dihasilkan oleh masing-masing optimasi. Kekurangan nutrisi dan intensitas cahaya yang tinggi menjadi pemicu C. calcitrans. mengakumulasi lipid, dan mempengaruhi profil asam lemak C. calcitrans.
La doble naturaleza del arte y el destino de lo humano
Authors: Zuñiga José F.
Published: January 2024

Partiendo de un análisis de la posición ambigua que tiene el arte en el mundo actual (entre la autonomía y la heteronomía), se formulan dos tesis. En primer lugar, se propone una tesis ontológica, según la cual el arte está constituido por un doble impulso: por un lado, un impulso constructivo, presente en toda praxis social y humana; por otro, un impulso destructivo, que actúa en los márgenes de la razón y de la sociedad y los sobrepasa. En segundo lugar, se propone una tesis práctica, según la cual la adecuada tensión entre ambos impulsos es la condición de posibilidad de la libertad humana. Mediante una confrontación entre Hegel y Kafka, teniendo presentes ambas hipótesis, planteo un desplazamiento en la definición del ser humano como animal racional. Para finalizar, hago ver que se trata, en el fondo, de un debate sobre el destino del ser humano.
Adorno, Hamlet y el factor añadido
Authors: Juárez Esteban Alejandro
Published: January 2024

Este artículo tematiza la relevancia del Hamlet, de Shakespeare, para el pensamiento de T. W. Adorno, aun cuando este no haya escrito in extenso sobre aquel. El drama aparece sobre todo en su discurso oral como modelo para describir la relación de discontinuidad entre teoría y práctica. Aquí se desea mostrar cómo el teórico crítico del pensamiento moral abstracto piensa el paso del conocimiento a la praxis a partir del vínculo entre Hamlet y el llamado “factor añadido” (Das Hinzutretende). Desde esta lectura, el Hamlet de Adorno representa un lugar clave de transiciones malogradas.
Lo social del arte y el arte social en Juan Mas y Pi
Authors: Rodríguez Martín Carmen
Published: January 2024

El objetivo del presente artículo es analizar los presupuestos del escritor, crítico y ensayista español Juan Mas y Pi (1878-1916) sobre la cuestión social del arte. Para ello, me serviré del texto “Arte social”, publicado en 1906 en la revista Germen. Revista popular de sociología, dirigida por Alejandro Sux. Abordaré cuál es el origen, la esencia y la función del arte para que obra, artista y experiencia estética sirvan a la causa del proceso de perfeccionamiento de la Humanidad hacia un futuro libre de cualquier tipo de opresión y sufrimiento
Jenófanes: ¿padre del escepticismo?
Authors: Sánchez Castro Liliana Carolina
Published: January 2024

Existe una tradición antigua que hace de Jenófanes de Colofón el padre del escepticismo. Esta idea, transmitida por varias fuentes, vincula al colofonio no solo con algunas tesis que fueron apreciadas por los escépticos antiguos sino, además, con una actitud hacia el conocimiento en general. En el presente texto estudiaré esa tradición escéptica con el fin de hacer explícitas las razones que hacen posible atribuirle dicha paternidad y las implicaciones que articulan dicha tradición tienen a la hora de interpretar su pensamiento.
¿Moralidad sin competencia? Dos interpretaciones de la objeción de inmoralidad al pirronismo
Authors: Ornelas Jorge , Lozano-Vásquez Andrea
Published: January 2024

Argumentamos en contra de dos intentos contemporáneos por rehabilitar el pirronismo debido a su incapacidad para resolver la clásica objeción de inmoralidad. Proponemos dos diferentes lecturas de la objeción: una débil, según la cual los pirrónicos son inmorales dado que sus actos mismos lo son —lo que constituye un cargo empírico—, y otra fuerte, donde la inmoralidad del pirrónico proviene del hecho de que, por diseño, no puede exhibir ningún tipo de competencia moral, lo que constituye un cargo conceptual. Concluyo que ambos intentos fracasan debido a que se atienen el sentido débil de la objeción, pero no el fuerte.
“Verum index sui et falsi” Certidumbre y duda escéptica en Spinoza
Authors: Sánchez de León Serrano José María
Published: January 2024

El articulo examina la aparente discrepancia en el pensamiento de Spinoza entre su teocentrismo epistemológico, según el cual todo es dudoso mientras desconocemos la existencia de Dios, y el principio verum index sui et falsi, según el cual la mera posesión de ideas verdaderas excluye toda incertidumbre. Lejos de contradecirse, estas dos afirmaciones constituyen en Spinoza dos aspectos correlativos del mismo planteamiento gnoseólogico. Se muestra así que la naturaleza divina no es ajena al intelecto humano y que este es capaz de contemplar la realidad desde una perspectiva omnímoda, idéntica a la de Dios.
La unidad del escepticismo humeano
Authors: Junqueira Smith Plínio
Published: January 2024

Los intérpretes han dividido la filosofía de Hume, su “lógica”, en dos partes: la destructiva, compuesta por sus análisis filosóficos, su crítica del racionalismo y sus momentos escépticos; la constructiva, que contiene su asociacionismo psicológico, su ciencia empírica de la naturaleza humana y sus momentos naturalistas o realistas. Mi intención es cuestionar cualquier interpretación que suponga esa dicotomía, y mostrar que Hume realiza ambas tareas al mismo tiempo, en etapas sucesivas. Muestro la unidad de su filosofía en tres tópicos: un examen de la articulación entre el principio de la copia y los principios de asociación; un análisis de la estructura de los argumentos de Hume una crítica de los supuestos momentos escéptico y naturalista.
En el origen fue la prótesis. La deconstrucción como crítica al nacionalsocialismo
Authors: Jerade Miriam
Published: January 2024

El presente artículo aborda tres aportes de la deconstrucción de Jacques Derrida a la crítica al nacionalismo en distintos momentos de su obra: a) la deconstrucción del mito de los orígenes como ideal de pureza que expone con la lógica del suplemento; b) la crítica a la noción de un idioma nacional pensado como el idioma de un “nosotros” a partir de una comunidad de espíritu y c) la deconstrucción de un nacionalismo a la vez cosmopolita y humanista, inclusive en filosofías críticas del humanismo y contrarias a cualquier determinación racial o natural.
Cesare Beccaria y la percepción (estética) como fundamento en su política-criminal
Authors: Carrasco-Jiménez Edison
Published: January 2024

El artículo hace un análisis del discurso de Beccaria contenido en su libro Dei delitti e delle pene y extrae las ideas relativas a la percepción como argumento considerable dentro de su propuesta político-criminal para fundar la utilización de ciertos instrumentos de la penalidad, con base en su pensamiento sobre la estética, entendida como un estudio sobre la percepción, realizado en algunas investigaciones personales. Igualmente, toma ciertas ideas de la epistemología gravitante de la época, para fundar su desiderátum político-criminal.
La crítica de Walter Benjamin al positivismo (en discusión con Hans Kelsen)
Authors: Parra Andrés
Published: January 2024

Varios estudiosos del ensayo benjaminiano Para una crítica de la violencia parecen coincidir en la tesis de que para el pensador alemán la violencia aparece como un medio del derecho. Sin embargo, la teoría pura del derecho de Kelsen reconoce que la violencia y la coacción son también un medio del derecho, pero justamente por ello niega cualquier relación fundamental, estructural o esencial entre derecho y violencia: un medio es únicamente una condición necesaria de algo, pero nunca su condición suficiente ni, por tanto, su fundamento. El propósito de este escrito es presentar una interpretación del texto de Benjamin que responda a la objeción kelseniana.
Odradek y el problema de la forma
Authors: Fernández H. Diego
Published: January 2024

El artículo examina el conflicto formal que se produce en la descripción de Odradek al interior de “La preocupación del padre de familia” de Franz Kafka. En la voz de su narrador, Kafka se vale de un lenguaje de extraordinaria precisión para describir a su criatura (Odradek), produciendo una serie de paradojas. Prestamos atención seria a estas paradojas, mostrando las consecuencias que ellas plantean para los conceptos de “historia” en Kant y Benjamin, en sus respectivas relaciones con el concepto de “naturaleza” en estos autores.
Post minería en Colombia: el camino hacia la sostenibilidad en la minería
Authors: Hernández Marco , Vallejo Tommy , Klinger Luis , Restrepo-Baena Oscar Jaime
Published: January 2024

En este artículo se pretende realizar un diagnóstico sobre la situación actual del cierre de las minas en Colombia, transferir el conocimiento y experiencia vivida por Alemania por los autores en ese aspecto, identificar la normatividad que se ha establecido en el país hasta la actualidad con respecto a cierre minero, los desafíos que enfrenta el país, las iniciativas y posibles soluciones  que ha efectuado el país en la actualidad para garantizar un cierre adecuado exponiendo  casos de éxito  y por último se concluye la necesidades, los responsables y la forma de abordar este tema tan importante y álgido para el país.
RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2
Authors: Yan Tingting , Lu Guangxin , Shang Rui , Hu Junhua , Zhu Chaobei , Jin Lingli
Published: January 2024

Objective

Gastric cancer is the most frequent gastrointestinal malignancy with a poor prognosis. Rac GTPase activation protein 1 (RACGAP1) is a novel tumor promotor, whose detailed effect on gastric cancer remains to be further elucidated. Hence, this study identifies the action of RACGAP1 on gastric cancer and investigates the potential mechanism.

Methods

RACGAP1 expression in gastric cancer was analyzed based on the data of The Cancer Genome Atlas (TCGA) database. Cell proliferation was measured by CCK-8 and colony formation assay. Cell migration and invasion were evaluated by transwell assay. Cell apoptosis was assessed by flow cytometry. Cell autophagy was evaluated via determining LC3.

Results

RACGAP1 presented at high level in gastric cancer cells. Overexpressed RACGAP1 potentiated gastric cancer cell proliferation, migration, and invasion. Besides, silenced RACGAP1 induced cell apoptosis and autophagy. Furthermore, RACGAP1 suppressed the expression of SIRT1 and Mfn2.

Conclusion

RACGAP1 was overexpressed in gastric cancer. RACGAP1 potentiated aggressive behaviors of gastric cancer, and suppressed cell apoptosis and autophagy via modulating SIRT1/Mfn2. RACGAP1 may be a valuable target in the treatment of gastric cancer.
Dynamic behavior of sorption of europium onto biotite flakes under the condition of saline groundwater
Authors: Chida Taiji , Seki Tsugumi , Watanabe Yuto , Niibori Yuichi
Published: January 2024

This study discussed the interaction between Eu and biotite in flakes under the coexistence of Na ions, considering saline groundwater. The sorption experiments were conducted by mixing an Eu solution with Na or K ions and biotite flakes at pH 5. Resultantly, the sorption of Eu gradually increased because of the diffusion into the layered structure of biotite flakes. Thereafter, the sorption amount of Eu with Na ions was less than that without Na ions, and Eu was hardly sorbed with K ions. Additionally, the apparent diffusion coefficients were estimated to be in the order of 10−13 m2/s based on a two-dimensional diffusion model. These values were lower than the effective diffusion coefficients in plutonic rock, which are employed to assess the performance of geological disposal systems. This indicates that the sorption of Eu in plutonic rock is restricted by the diffusion process in biotite flakes.

Graphical abstract
Infant Mortality by Selected Maternal Characteristics and Race and Hispanic Origin in the United States, 2019-2021
Authors: Ely Danielle , Driscoll Anne , Shin Hee-Choon , Chen Te-Ching
Published: January 2024

This report provides health data from the National Center for Health Statistics.
Hysterectomy Among Women Age 18 and Older: United States, 2021​
Authors: Gorina Yelena , Elgaddal Nazik , Weeks Julie D. , Pingali Cassandra , Valenzuela Claudia
Published: January 2024

This report provides health data from the National Center for Health Statistics.
A epistemologia da transformação: uma crítica ao neo-Ricardianismo
Authors: GONTIJO CLÁUDIO
Published: January 2024

RESUMO Na solução do “problema da transformação”, Marx errou ao acreditar que a taxa de lucro determinada no sistema de valores era a mediação entre valores e preços de produção. Este erro invalida o “postulado duplo” de Marx, segundo o qual a soma dos valores é igual à soma dos preços e a soma da mais-valia é igual à soma dos lucros. Usando um operador linear do sistema de valor, é possível determinar completamente a taxa média de lucro e o sistema de preços de produção. Dessa forma, podemos preservar o postulado epistemológico fundamental de Marx, segundo o qual o reino da essência (valores) determina o reino da realidade transparente (preços).
O caráter cíclico da intervenção estatal
Authors: BRESSER-PEREIRA LUIZ CARLOS
Published: January 2024

RESUMO A atual onda de privatizações e o relativo sucesso da crítica neoliberal ao papel econômico do Estado fazem parte do caráter cíclico da intervenção estatal. Estamos agora na recessão do ciclo. Durante a recuperação, a intervenção do Estado, medida em termos de nacionalização e aumento da regulamentação, é inicialmente bem-sucedida, mas depois de algum tempo incorre em distorções crescentes. A crise e as críticas que acompanham as distorções levam a uma redução e principalmente a uma mudança no padrão de intervenção do Estado. Mas nunca a um retorno ao L’Etat gendarme sonhado pelos neoliberais.
Sobre a crise do Estado brasileiro
Authors: FIORI JOSÉ LUÍS
Published: January 2024

RESUMO No centro da atual crise da economia e da sociedade brasileira está a crise do Estado. Para entender essa crise, este trabalho faz uma revisão da natureza e do papel do Estado brasileiro no presente e no passado. O artigo argumenta que no capitalismo periférico, como o brasileiro, o Estado tem desempenhado papéis diferentes e produzido efeitos diferentes em relação ao Estado dos países desenvolvidos. Aqui o Estado não é apenas um componente essencial e fundamental do processo de acumulação do capital, mas tem dificuldade em desempenhar o papel de árbitro dos conflitos de classes e da competição entre diferentes grupos de interesse. Entre outras coisas, a natureza do Estado brasileiro produziu e reproduziu desigualdades crescentes e heterogeneidade estrutural.
Climate drivers afecting upland rice yield in the central region of Brazil
Authors: Heinemann Alexandre Bryan , Stone Luís Fernando , Silva Guilherme Custódio Cândido , Matta David Henriques da , Justino Ludmilla Ferreira , Silva Silvando Carlos da
Published: January 2024

ABSTRACT The upland rice production is primarily concentrated in a vast area of central Brazil. Given the region’s environmental variability, the performance of rice cultivars can differ signifcantly. This study aimed to identify the key climate factors infuencing the upland rice yield in the central region of Brazil, encompassing four states: Goiás, Mato Grosso, Tocantins and Rondônia. A dataset comprising 177 trials involving commonly cultivated and well-adapted upland rice varieties, derived from the Embrapa’s rice breeding dataset, was analyzed. These trials were conducted in randomized blocks, with three replications, from 1996 to 2018. The generalized additive model approach was employed to adjust the non-linear relationships between environmental factors and grain yield, revealing four climatic variables: maximum air temperature throughout the growth cycle, minimum air temperature at panicle initiation, degree-days from emergence to panicle initiation and degree-days throughout the growth cycle. An increase in the maximum air temperature and degree-days throughout the growth cycle tend to decrease rice yield, while an increase in the minimum air temperature at the panicle initiation and degree-days from emergence to panicle initiation tend to increase it.
Checklist of relevant ICF categories for speech and language development
Authors: Pinto Fernanda Chequer de Alcântara , Schiefer Ana Maria , Perissinoto Jacy
Published: January 2024

ABSTRACT Purpose Create a checklist of the International Classification of Functioning, Disability and Health (ICF) based on relevant categories for the development of speech and language, according to the perception of parents and speech therapists. Methods Pilot application and research were carried out. 100 parents of preschool children with typical language/cognition development and 57 language specialist speech therapists participated in the survey. A questionnaire was created with 199 ICF categories of body function components, activities and participation, and environmental factors. Each category was scored as: indispensable (2); important (1) or unimportant (0). Statistical analysis was performed (descriptive, sum, cluster/K-means and Mann-Whitney method). Results With the sum of the points (essential, important and unimportant) and the number of responses essential, the most relevant categories were identified for each group of respondents, as well as the set of categories in common (72 considered to have the greatest influence). The common list to the groups included the three components: body functions (30 categories/40% of the total), activities and participation (35/49.29%) and environmental factors (seven/13.20%). From the selected categories, 58.33% presented statistically significant results between the groups, regarding the relevance given. Conclusions The categories were considered with different scores between the groups: those of body functions were more scored by speech therapists, while those of environmental factors by parents. Thus, it was possible to create a checklist from the identification of the most relevant categories for the development of speech and language, in preschool age, contemplating the components of body functions, activities and participation and environmental factors.
IN SEARCH OF AN INTEGRATIVE FRAMEWORK FOR FEMALE IMMIGRANT ENTREPRENEURSHIP
Authors: Cunha Victoria Barboza de Castro , Nascimento Thiago Cavalcante , Falcão Roberto Pessoa de Queiroz
Published: January 2024

ABSTRACT Female entrepreneurship (FENT) has long been presented as primarily driven by necessity, encompassing gendered social processes that push women into venturing to find independence, self-assurance, financial relief, or a more balanced lifestyle. Extant research also identified differences in motivations and barriers to female self-employment in developing versus developed countries. Thus, the article proposes an integrative framework combining Mixed Embeddedness and Institutional Theory to analyze immigrant women’s entrepreneurial process, adopting a multi-theoretical lens to deepen the understanding of women’s entrepreneurial practices, addressing Granovetter’s embeddedness’ inconsistencies.
APRENDIZAJE CREATIVO DURANTE LA FORMACIÓN DE PROFESIONALES INFORMÁTICOS
Authors: Hernández Walfredo González , Roldá Maritza Petersson , García Marcelina Caridad Moreno
Published: January 2024

La formación de profesionales informáticos creativos se considera como un proceso estratégico en diferentes países al resultar esencial para la informatización de la sociedad. El presente artículo plantea un acercamiento al aprendizaje creativo de la informática para la transformación digital de la sociedad moderna. El objetivo de la investigación fue evaluar el aprendizaje creativo de la informática durante la formación de profesionales informáticos. Se aplicó un instrumento derivado de investigaciones anteriores y métricas para evaluar el aprendizaje creativo en los dos grupos de años terminales de la carrera de Ingeniería Informática de la Universidad de Matanzas, Cuba, con un paradigma mixto. Los análisis cuantitativos diagnosticaron el aprendizaje predominante en la carrera que ofrecen elementos a los directivos para tomar decisiones. Por su parte, los análisis cualitativos permitieron develar las cuatro etapas de formación del aprendizaje creativo de la informática en la carrera: etapa preuniversitaria, etapa básica, etapa profesional y etapa de investigación. Además, permitieron obtener tres factores claves en la formación del aprendizaje creativo de la informática: la integración de asignaturas, la solución de proyectos reales y el acompañamiento emocional de los profesores y otros profesionales a los estudiantes durante su inserción en la informatización de organizaciones.
The role of natural sorbents and piping production waste in the treatment of acid iron-containing waste water
Authors: Bryukhov Mikhail N. , Ulrikh Dmitrii V. , Lonzinger Tatiana M. , Denisov Sergey E.
Published: January 2024

In this article, we consider the sorption purification of production wastewater from pipe industry enterprises. We have presented and studied the potential sorbents from among natural materials and from piping production waste. The authors of this paper have studied the sorption capacity of the materials under consideration with regard to heavy metals from highly acidic iron-containing wastewater both in static and dynamic modes. The static-mode research has been conducted for various temperatures: 10°С, 20°С and 30°С. In the dynamic conditions, the filtrate flow rate equaled 0.3, 0.6 and 1.2 l/h. The authors have proven that a number of the examined materials can be used as sorbents or constituting elements of composite sorbents for the technology of wastewater treatment at pipe industry enterprises.
Determination of the design features of the device for neutralizing toxic components of flue gases
Authors: Balandina Olga A.
Published: January 2024

The influence of the boiler unit load on the area of heterogeneous reactions of the process of catalytic flue gas purification is considered. The optimal geometric characteristics of the neutralizer monolith were determined when the steam capacity of the TGME-464 boiler unit varied from 220 to 500 t/h. The calculations were performed using a mathematical model for the conditions of the operating power equipment. The optimal size of the unit cell of the catalyst block is determined in a wide range of boiler load regulation. The data obtained as a result of the study formed the basis for designing a sample of an industrial neutralizer of toxic flue gas components without the introduction of an external reagent.
Drawingless design (Russian Middle Ages)
Authors: Slavina Tatyana A.
Published: January 2024

Eight centuries of the Russian Middle Ages left great architecture, but not a single design drawing. The article examines the reasons for this fact, as well as features of the drawingless creative process and its usefulness.
Scientific and practical proposals in the field of architectural organization of residential buildings for social purposes in the cities of Donbass
Authors: Pestryakova Elvira R.
Published: January 2024

This article is devoted to the relevance of housing construction for low-income segments of the population, creating conditions for the economic recovery of the region. The author considers various aspects of housing conditions, such as accessibility, quality, comfort, functionality. For the possibility of creating high-quality and comfortable housing conditions in the cities of Donbass, an analysis of the existing housing stock of buildings of small and medium storeys was carried out with the identification of their features in the architectural organization. The author has studied various characteristics of existing residential buildings with a further conclusion about the improvement of the housing stock of the region. The existing methods of designing mass housing construction are investigated in order to identify the main aspects that affect the quality and comfort of living. The article presents scientific and practical suggestions and recommendations in the field of architectural organization of residential buildings for social purposes.
Practical foundations and methodology architectural and town-planning improvement and development of urban development facilities in the conditions of reconstruction
Authors: Radionov Timur V.
Published: January 2024

The research is aimed at solving the most important economic problems that determine the practical foundations and methodology of architectural and urban planning objects involved in the reconstruction process. Methodological approaches in the field of reconstruction of buildings and structures, including urban areas, are summarized, indicating the need to develop a comprehensive algorithm that allows the process of improving and developing architecture to be considered from a scientific and practical point of view. The author of the article has developed practical recommendations in the field of reconstruction of urban development objects and adjacent territories, based on the concept of search architectural and urban planning modeling in the development of complex project proposals.
Eurozone inflation: fresh projections from global factors
Authors: Apergis Nicholas
Published: January 2024

This study identifies the contributions of global factors in determining eurozone inflation. The analysis makes use of an augmented Phillips curve model of inflation, as well as panel data estimates. The findings document the importance of such factors in forecasting inflation, thus, confirming the substantial role of external factors in eurozone inflation. The findings survived certain model specifications. Therefore, monetary, and fiscal policymakers should explicitly consider both domestic and global conditions to anchor inflation expectations in forming specific strategies for taming inflation expectations.
Tax policy cyclicality and financial development
Authors: Chrysanthakopoulos Christos , Tagkalakis Athanasios
Published: January 2024

This paper adds to the existing literature by examining the macroeconomic, political and institutional determinants of tax policy cyclicality conditional on financial development. We find that an increase in trade and financial openness leads to pro-cyclical VAT and counter-cyclical CIT rate response in high financially developed economies, while an increase in financial openness is associated with counter-cyclical VAT and PIT responses when the levels of financial development are low. A high public debt ratio leads to a counter-cyclical VAT rate response in economies with low financial development. Political power and fiscal institutions are factors that affect the tax policy cyclicality only in less financially developed economies.
A clinical case of Urbach-Wiethe disease
Authors: Kobernik М. Yu. , Elkin V. D. , Sedova Т. G.
Published: January 2024

A clinical description of Urbach – Wiethe disease (lipoid proteinosis), an extremely rare pathology, is presented, currently only 300 cases are known. This hereditary disease, transmitted by an autosomal recessive type, is associated with a mutation of the extracellular matrix 1 (ECM1) gene located on chromosome 1, locus 1q21. It is based on a violation of collagen synthesis and deposition of hyaline in the dermis along the collagen fibers, in the mucous membranes, sometimes in the internal organs. The chemical composition of hyaline is not completely determined; it is noted that it includes collagen, glycoproteins, lipids, proteoglycans. The disease begins in early childhood and is characterized by changes in the ENT organs and skin, confirmed by histological examination, which reveals thickening of the dermis, degeneration of collagen fibers, hyalinosis with deposition around the vessels, in their walls, around the sweat glands of ribbon-like, weakly eosinophilic, homogeneous substances, which include phospholipids, sometimes there may be cracks with deposition of lipids.

Patient V., born in 1990, the disease began almost from birth with the appearance of polymorphic rashes on the skin and hoarseness of the voice. In 1999, a histological examination of the affected skin was performed, confirming the diagnosis of lipoid proteinosis of Urbach – Wiethe. The skin pathological process is widespread, symmetrical, on the face it is represented by reticulated telangiectatic erythema, along the edge of the lower eyelids there are miliary nodules similar to a string of pearls. Hypoplasia and stagnant erythema of the auricles are determined. There are yellowish lenticular papules on the trunk and limbs, waxy translucent plaques of a dense consistency in the area of the extensor surface of the elbow joints. Besides, secondary hyperpigmentation and foci of atrophy were detected on the face, trunk and limbs. Skin changes are accompanied by lesion of the ENT organs in the form of bilateral maxillary sinusitis, frontitis, chronic pharyngitis, chronic laryngitis. Concomitant pathology is important: polyvalent sensitization, chronic hepatitis B, biliary dyskinesia against the background of gallbladder deformation, chronic gastroduodenitis. The patient has been on disability since 2000, needs dispensary supervision and correction of all identified violations.
Caroli's disease with multiple cholangiogenic abscesses of left liver lobe: a clinical case
Authors: Styazhkina S.  N. , Zaitsev D.  V. , Klimentov M.   N. , Larin V. V. , Gasanova M. А. , Chakmina M. I.
Published: January 2024

To analyze the methods of diagnostics, treatment and outcomes of Caroli disease. The medical history, diagnostic methods and treatment of a patient with a clinical diagnosis of Caroli's disease were studied on the basis of the Surgical Department of the First Republican Clinical Hospital in Izhevsk. The results of the study showed that the final clinical diagnosis was made on the basis of the following: complaints, disease development, instrumental and laboratory diagnostic data. A timely surgical intervention, combined with all diagnostic methods, identified a rare and difficult clinical diagnosis – Caroli’s disease. In the presented clinical case, after collecting anamnesis and conducting studies, a diagnosis of a rare Caroli’s disease was made and a planned operation was performed. A regular monitoring of X-ray examinations, biochemical blood tests, and a timely medical care provide a favorable prognosis – long-term remission. In case of complications, there is a high risk for the development of biliary cirrhosis.
Effect of peptides of trophoblastic Β1 glycoprotein on peripheral and local T-regulatory lymphocytes level in Wistar rats with allogeneous bone marrow cell transplantation
Authors: Zamorina S. А. , Bochkova М. S. , Timganova V. P. , Vlasova V. V. , Lyubimov А. V. , Loginova N. P. , Charushina Yu. A. , Chemurzieva N. V. , Rayev М. B.
Published: January 2024

Objective. The range of peptide drugs is expanding, but no drug with immunosuppressive activity has yet been found. Considering the fact that the trophoblastic β1-glycoprotein (PSG) is a fetoplacental protein with immunosuppressive activity, short peptide fragments of this protein were studied in the formation of an immune response in a situation of allogeneic cell transplantation. To study the effect of PSG peptides (YECE, YQCE, YVCS, and YACS) on the levels of peripheral and local T-regulatory cells (Treg) during the formation of an immune response to the introduction of allogeneic bone marrow cells (BM) in a dynamic experiment on Wistar rats.
Materials and methods. We used an original host-versus-graft model in male Wistar rats without preconditioning of recipients. Animals were injected with PSG peptide fragment composition against a background of allogeneic intraperitoneal transplantation of BM cells in a dynamic experiment, in which the following parameters were evaluated: the level of peripheral "true" Tregs (CD4+CD25+FOXP3+), CD4+CD25-FOXP3+ cells, and FOXP3 expression in mesenteric lymph nodes. Material was collected on days 3 and 21 of the experiment.
Results. PSG peptide administration against a background of allogeneic BM cells was found to reduce the absolute and relative amount of Treg in the peripheral blood of rats on days 3 and 21 of the experiment. PSG peptides against the background of the introduction of allogeneic BM cells reduced the absolute and relative amounts of CD4+CD25-FOXP3+ cells on the day 3 of the experiment. The introduction of PSG peptides against the background of the introduction of BM cells resulted in a relative decrease in FOXP3 expression in the T zone of mesenteric lymph nodes on the day 21 of the experiment.
Conclusions. Thus, the PSG peptides did not have the expected effect on the level of peripheral and local Treg cells; moreover, the presence of the peptides led to a decrease in the number of these cells.
Experimental studies of effectiveness of a new mineral complex for regeneration of epithelial tissues and skin
Authors: Mishlanov V. Yu. , Chereshnev V. А. , Vdovina G. P. , Burlutskaya А. А. , Zuev А. L. , Koshurnikova E. P. , Emelkina V. V. , Samartsev V. А. , Gavrilov V. А.
Published: January 2024

Objective. To study the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver in model experiments of the planar skin wounds and acute bronchitis in laboratory animals for the development of new techniques of surgical and pulmonological diseases treatment.

Materials and methods. An experimental study of the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver was carried out on models of the planar skin wounds and acute bronchitis in rats.

Results. The results of histological examination of tissues showed the advantage of the mineral complex over the control groups of animals. The anti-inflammatory and regenerative activity of the mineral complex was established in a model of acute bronchitis and regenerative activity in a model of a planar skin wound.

Conclusions. The effectiveness of the mineral complex depended on the concentration of cerium ions and was manifested at a dose of 0.003 μg/kg of animal weight.
Scientist, teacher and head of the largest department of anatomy in the USSR: professor E.N. Olenyova – 100th anniversary of her birth (14.04.1923–16.10.2001)
Authors: Balandina I. А. , Lebedinskaya О. V.
Published: January 2024

The article is devoted to Professor of the Department of Normal Anatomy Elizaveta Nikolaevna Olenyova, her life and activity. When Elizaveta Nikolaevna headed the department, the study of lymphatic system of the body in norm, experiment and pathology became the main scientific trend. Thus in these years, the work of E.N. Olenyova and her colleagues laid the basis for clinical lymphology.
Immediate and medium-term results of aortic valve replacement with biological prosthesis in elderly patients: experience of one center
Authors: Kadyraliev B. К. , Belov V. А. , Arutyunyan V. B. , Marchenko А. V. , Kdralieva N. V. , Enginoev S. Т. , Kuchumov А. G.
Published: January 2024

Objective. To analyze the immediate and medium-term results of prosthetics of the aortic valve (AV) using biological prosthesis in elderly patients.
Material and methods. The study included 198 patients with AV pathology [85 men (42.9 %)/113 women (57.1 %)]. The median age was 70 [66–73] years. There were 175 (88.4 %) patients with sclerodegenerative AV, 5 (2.5 %) – with infectious endocarditis and 30 patients (15.2 %) had bicuspid AV.
Results. The hospital mortality was 4.5 %. The causes of mortality were multiple organ failure syndrome, in 1 case – developed peritonitis. In 14 patients (7.1 %) there was a rhythm disturbance in the form of AF, in 9 (4.5 %) – a complete AV block, in connection with which a permanent pacemaker was implanted. Four patients (2 %) underwent resternotomy for bleeding. Two patients (1 %) underwent pericardiocentesis. 8 (4 %) patients developed a stroke. No wound complications were detected. In the long-term period, 31 patients died. The causes of mortality were the following: cardiovascular diseases – 13 patients, malignant neoplasms – 5 patients, gastrointestinal diseases – 2, urinary system disease – 1 patient, COVID-19 – 1 patient, unknown cause – 9 patients. Thus, the five-year survival rate after the surgery was 63 %, respectively. During the follow-up period, 2 patients (2.9 %) underwent repeated intervention on AV.
Conclusions. The five-year freedom from re-operation was 97.1 %. The five-year survival rate was 63 % due to the presence of a history of severe concomitant pathology as well as the middle age of patients 70 years.
Dynamics of benign mammary dysplasia incidence in women over the working age at regional level
Authors: Севостьянова O. O. , Chumarnaya Т. V. , Oboskalova Т. А. , Sevostyanova N. E. , Vorontsova A.  V.
Published: January 2024

Objective. To determine the epidemiological patterns of the incidence and prevalence of benign mammary dysplasia (BMD) in the adult female population over the working age in Sverdlovsk Region and the city of Ekaterinburg in 2012–2021.
Materials and methods. The incidence and prevalence of BMD in Sverdlovsk Region and Yekaterinburg in 2012–2021 were analyzed in comparative aspect.
Results. In 2012–2019 BMD incidence among women over the working age was characterized by a tendency to grow in Sverdlovsk Region. Regarding Yekaterinburg, this index was – 0.9 %. The prevalence of BMD in 2014–2019 in the region and the city statistically significantly exceeded the values in 2012 (p 0.001). The average rate of growth in the region and city had a marked dynamics of increase and was 8.08 % and 7.84 %, respectively. In 2020–2921, there was observed a sharp decrease in the regional and city indices. The average rate of growth was – -33.11 %, prevalence – -11.21 %.
Conclusions. In 2012–2019, the BMD incidence in the female population over the working age was characterized by a moderate tendency to grow in Sverdlovsk Region and the absence of dynamics in Yekaterinburg. Prevalence had a pronounced dynamics of increase in the city and region, that proves a chronic character of the disease and organization of follow-up observation among patients.
Comparison of atezolizumab plus bevacizumab and lenvatinib for hepatocellular carcinoma with portal vein tumor thrombosis
Authors: Park Jeayeon , Lee Yun Bin , Ko Yunmi , Park Youngsu , Shin Hyunjae , Hur Moon Haeng , Park Min Kyung , Lee Dae-Won , Cho Eun Ju , Lee Kyung-Hun , Lee Jeong-Hoon , Yu Su Jong , Kim Tae-Yong , Kim Yoon Jun , Kim Tae-You , Yoon Jung-Hwan
Published: January 2024

Background/Aim: Atezolizumab plus bevacizumab and lenvatinib are currently available as first-line therapy for the treatment of unresectable hepatocellular carcinoma (HCC). However, comparative efficacy studies are still limited. This study aimed to investigate the effectiveness of these treatments in HCC patients with portal vein tumor thrombosis (PVTT).Methods: We retrospectively included patients who received either atezolizumab plus bevacizumab or lenvatinib as first-line systemic therapy for HCC with PVTT. Primary endpoint was overall survival (OS), and secondary endpoints included progressionfree survival (PFS) and disease control rate (DCR) determined by response evaluation criteria in solid tumors, version 1.1.Results: A total of 52 patients were included: 30 received atezolizumab plus bevacizumab and 22 received lenvatinib. The median follow-up duration was 6.4 months (interquartile range, 3.9-9.8). The median OS was 10.8 months (95% confidence interval [CI], 5.7 to not estimated) with atezolizumab plus bevacizumab and 5.8 months (95% CI, 4.8 to not estimated) with lenvatinib (P=0.26 by log-rank test). There was no statistically significant difference in OS (adjusted hazard ratio [aHR], 0.71; 95% CI, 0.34-1.49; P=0.37). The median PFS was similar (P=0.63 by log-rank test), with 4.1 months (95% CI, 3.3-7.7) for atezolizumab plus bevacizumab and 4.3 months (95% CI, 2.6-5.8) for lenvatinib (aHR, 0.93; 95% CI, 0.51-1.69; P=0.80). HRs were similar after inverse probability treatment weighting. The DCRs were 23.3% and 18.2% in patients receiving atezolizumab plus bevacizumab and lenvatinib, respectively (P=0.74).Conclusion: The effectiveness of atezolizumab plus bevacizumab and lenvatinib was comparable for the treatment of HCC with PVTT.
Zoonoses, and the wave of the COVID-19 pandemic
Authors: Parwanto ML Edy
Published: January 2024

Zoonoses are a group of diseases that can be transmitted to humans by non-human vertebrate animals. The source of zoonoses is a large number of domesticated and wild animals. Causes of zoonoses include viruses, bacteria, parasites, and fungi. Initially, it was stated that COVID-19 was caused by the novel coronavirus 2019 (nCoV-2019), then WHO stated that the name that caused COVID-19 was severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 caused by SARS-CoV-2 has been classified as a zoonotic disease, no animal reservoir has been found, so the classification is premature. The proposed term for COVID-19 is classified as an “emerging infectious disease (EID) of probable animal origin.” Transmission of COVID-19 is exclusively in the form of human-human transmission, so it is not in accordance with the zoonotic definition of WHO.
Clarithromycin: overview and its current clinical utility in the treatment of respiratory tract infections
Authors: Naik Prashant , Prabhat Divya , Shrivastava Rakesh , Nair Arun , Khandke Devendra
Published: January 2024

Upper respiratory tract infection (URTI) is a common reason for medical consultation all over the world. Streptococcus A (Strep A) and other infections can cause sore throat as well as pharyngitis or tonsillitis. It may also result in post-infection sequelae, including acute post-streptococcal glomerulonephritis, acute rheumatic fever, and rheumatic heart disease.  As a result, there is a need for an antibiotic that is effective, easy to administer, has a favorable sensitivity pattern, and preferably has some additional pharmacodynamic properties that complement the basic antibacterial profile. Clarithromycin is a macrolide antibacterial agent with broad-spectrum activity against respiratory pathogens. It is especially active against atypical Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella spp. It is well absorbed and stable at gastric pH. It is metabolized by the cytochrome P450 enzymes and forms 14-hydroxy clarithromycin, which is more active than the parent compound, especially against Hemophilus influenzae. It acts by preventing protein synthesis by binding to the 50S subunit of bacterial ribosomes. In dosages of 500 to 1000 mg/day for 5 to 14 days, clarithromycin is effective in the treatment of community-acquired upper and lower respiratory tract infections in hospital and community settings. It exerts significant anti-inflammatory, immunomodulatory, and post-antibiotic effects. It provides a viable option for the treatment of community-acquired respiratory tract infections, in both children and adults.
Sarcomatous transformation of florid cemento-osseous dysplasia: a case report
Authors: Biswas Sailendranath , Saha Anindita , Das Asish K. , Ganguly Shreya
Published: January 2024

Florid cemento-osseous dysplasia (COD) represents a rare group of benign fibro-osseous disorders, while osteogenic sarcoma (OS) on the other hand, is a malignant tumour of ominous prognosis. The malignant transformation of a benign fibro-osseous lesion of the jaw is quite uncommon and has few reported cases. The clinico-radiological findings and histopathological analysis of a lesion present in all four quadrants of the jaw of a patient who reported at the outpatient department of a regional dental college is presented here. The lesion underwent sarcomatous transformation over two months and the findings were confirmed by histopathological evaluation. Although florid cemento-osseous dysplasia is a benign lesion of the jaw with a very low propensity for malignant transformation, it should be closely monitored in patients with tumour predisposition syndromes. Further research and molecular studies are required for better understanding of inadvertent changes.
Cancer death scenario: A brief concept on cancer related deaths
Authors: Raj Mukut , Priya Manu , Singh Hemant Kumar , Swain Suryakanta
Published: January 2024

A mass of aberrant tissue that has grown as a result of excessive, autonomous, and uncontrolled cell proliferation is known as a cancer, neoplasm, or tumour. The loss of the cell's regulatory system and an aberrant chromosome or DNA mutation are both contributing factors to this condition. Neoplasm refers to new growth, and neoplasia refers to the process of cell proliferation. Oncology, which derives from the Greek words oncos, which means tumour, and logos, which means study, is the area of medicine that deals with the thorough examination of a neoplasm (tumour), as well as its growth, diagnosis, and treatment. Generally, all malignant tumours are referred to as cancer. A safe and effective alternative for the treatment of tumours that produce granular exocytosis (perforin and granzymes) and death and do not respond to conventional treatment, cancer immunotherapy has emerged in recent years as two primary pathways implicated in CL-mediated tumour cell death. Treatments, including various ligand kinds, are briefly discussed before a comprehensive analysis of high aggressiveness. New immune modulators include immunotherapy, CTLA-4 blockers (cytotoxic T-lymphocytes unsupervised), and drugs involved in cell death during immunological cancer. Due to metastases from neighbouring organs and coexisting conditions such cirrhosis and chronic hepatitis, primary liver cancer is challenging to precisely diagnose after death. By altering the base rate or by influencing risk modification by sex and age, trends in diagnostic accuracy may have an impact on estimates of the radiation risk for liver cancer.