bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Differential Costs of By-Products to Generate Differential Income at PT Pathemaang Raya Bitung
Authors: I. Pateda Mutiara , Z. Tirayoh Victorina , Syermi S.E Mintalangi
Published: November 2023

Differential cost analysis is an analysis used to compare the differences between income and costs between existing alternatives to assist management in making decisions about which alternative to choose. Meanwhile, differential income is future information in the form of income that is different between decision alternatives and other decision alternatives. The aim of this research is to find out whether by-products can generate Differential Income at PT Pathemaang Raya Bitung. The research object is PT Pathemaang Raya Bitung. The research method used is Qualitative Descriptive. The research results show that by continuing the company's production of leftover goods into by-products, the company will generate Differential Income from the sale of these by-products.
Correlation of Chemotherapy Frequency with Albumin Levels and Weight Loss in Breast Cancer Patients at Abdoel Wahab Sjahranie Samarinda Regional General Hospital
Authors: Halwa Salsabilla , Pramono Joko Sapto , Reski Sepsina
Published: November 2023

East Kalimantan is ranked 2nd highest in breast cancer in Indonesia. One of the cancer treatments is chemotherapy. Chemotherapy causes effects such as nausea and vomiting and hematological toxicity. Nausea and vomiting are the main factors causing weight loss, and hematological toxicity is the main factor causing hypoalbuminemia. This study aims to determine the relationship between chemotherapy frequency and albumin levels and weight loss in breast cancer patients. The research was conducted in September 2023. There were 33 respondents. The instruments used are digital scales and medical records. Data analysis used the chi-square test (α<0.050). The results of the study showed that there was no relationship between the frequency of chemotherapy and albumin levels (p=0.084) and there was a relationship between the frequency of chemotherapy and weight loss (p=0.030) with a fairly strong relationship (r=0.441).
The Influence of Employee Engagement and Self-efficacy on the Performance of PDAM Tirtauli Pematangsiantar Employees
Authors: Sembiring Pricila Natalia , Siregar Onan Marakali
Published: November 2023

This research aims to determine the influence of Employee Engagement and Self-efficacy on employee performance at PDAM Tirtauli Pematangsiantar. This research uses quantitative methods involving 74 employees as research samples. The sampling technique is Simple Random Sampling. The data collection used was a questionnaire using a Likert scale which was distributed to respondents directly. The data analysis technique uses instrument validity and reliability testing, classical assumption testing and hypothesis testing using multiple linear regression analysis assisted by SPSS. The results of this research show that employee engagement and self-efficacy variables have a positive and significant effect on employee performance partially and simultaneously. The coefficient of determination test shows that there is a fairly close relationship between employee engagement and self-efficacy on employee performance with an R value of 0.661.
Analysis of Production Cost Calculations using the Direct Costing Method at PT Fortuna Inti Alam
Authors: Manuho Priskila , Saerang David Paul Elia , Pusung Rudy Johanis
Published: November 2023

The Direct Costing method is a production cost calculation method that only charges costs that are variable or that are directly related to the product. This research aims to find out how to calculate production costs using the direct costing method at PT Fortuna Inti Alam. The research method used in this research is descriptive qualitative. The results of the research show that the calculation of production costs at PT Fortuna Inti Alam uses a company method that charges all costs incurred within the company, resulting in a total production cost of IDR 2,442,117,500. Meanwhile, using the direct costing method results in total production costs of IDR 2,075,470,000. The results of these calculations cause a difference in total production costs, namely Rp. 366,647,500, where calculating production costs using the direct costing method results in total production costs that are smaller than the company's method.
Analysis of the Implementation of Activity Based Costing to Increase Cost Efficiency at Hotel Mel's in Manado
Authors: Tesya Sisilia Lupa  , Natalia Y. T. Gerungai  , Priscilia Weku
Published: November 2023

Activity Based Costing is a system of accumulating costs and assigning costs to products using various cost drivers, carried out by tracing costs from activities and after that tracing costs from activities to products. The aim of this research is to find out how to apply activity based costing to increase cost efficiency at the Mel's Inn Manado Hotel. The data analysis method used in this research is the descriptive analysis method. Based on the research results obtained, the basic price of the room is a nominal value that is smaller than that determined by the hotel management. With a lower HPP for each room, it can be seen that the cost of goods sold has the lowest difference for the superior room type, this is because the amount of labor used is more than the working hours for other room types
Administration System Analysis at Warehouse PT. Roots of Independent Blessing
Authors: Intan Puspita Ayudita Putri Widjanarko  , Christian Wiradendi Wolor  , Marsofiyati
Published: November 2023

This research aims to analyze the administration system at the PT Akar Berkat Mandiri Warehouse which occurs because the system is still manual, often making it slower and more time consuming than using an automated system, thus hampering work productivity. This research uses a qualitative descriptive approach method with Non-Probability Sampling, namely by describing and analyzing the problems found. The research results show that there is a problem with the management system of PT Akar Berkat Mandiri, namely that some documents are best because the management of the system is still manual, which makes the data input process take longer and the data input is still messy.
The Effect of Giving Moringa Leaf Tea and Honey on Increasing Breast Milk (ASI) Production in Postpartum Mothers on Days 1-7 in the Working Area of the Handil Baru Community Health Center
Authors: Rafika Nur Indasar  , Novi Pasiriani  , Faridah Hariyani
Published: November 2023

Breast milk is the best food for babies, but the rate of exclusive breastfeeding is still low due to insufficient breast milk production, so there is a need to provide intervention in the form of giving Moringa leaf tea and honey which contain nutrients (energy, carbohydrates, protein) which function as energy. the posterior pituitary produces the hormones oxytocin and prolactin and increases breast milk production. To determine the effect of giving Moringa leaf tea and honey on increasing breast milk (ASI) production in postpartum mothers on days 1-7 in the Handil Baru Community Health Center working area. This type of research uses quasi-experimental research design, namely nonequivalent control group design. Production of breast milk (ASI) after being given Moringa leaf tea and honey to postpartum mothers on days 1-7 of all respondents was 100% sufficient breast milk.
The Effect of Providing People’s Business Credit (KUR) on Increasing MSME Income in Praya Tengah District, Central Lombok Regency
Authors: Sertiningsih  , Bambang  , Iman Waskito
Published: November 2023

This research aims to determine the effect of providing People’s Business Credit (KUR) on increasing MSME income in Praya Tengah District, Central Lombok Regency. This research uses Stakeholder Theory and Agency Theory. This research uses primary data with quantitative methods. The population in this research is MSMEs that took credit at PNM Mekaar Central Praya Branch for the 2021-2022 period, totaling 441 MSMEs and a sample of 86 MSMEs was obtained. The sampling technique uses a purposive sampling technique with a data collection method, namely a questionnaire. Data analysis technique in research use descriptive statistics and simple linier regression analysis. The research results show that the People’s Business Credit (KUR) variable has an effect on inncreasing MSME income.
Promoting sustainable development issues through a creativity-centered e-learning course
Authors: Oskina Anna , Darinskaia Larisa
Published: November 2023

Purpose: One of the talents necessary for surviving in the modern economy is creativity which may be developed when students learn about global concerns through education for sustainable development which is recognised as having transformational power.   The aim of this research is to propose an electronic course structure promoting sustainable development issues and developing students’ creativity and to test its effectiveness. 

Design/Methodology/Approach: During the formative pedagogical experiment (2021-2022) in the experimental group of 28 first-year television studies students, we modelled a creative seminar structure and used it to develop an electronic English language course in the Moodle Learning Management System.  The control group included 27 1st year students of the same major who followed the curriculum-planned course. The results of the pre- and post-experimental questionnaire surveys were analyzed with the Mann Whitney U and ANOVA tests.

Findings: According to the results of the post-experimental diagnostics, the students of the experimental group demonstrated a more positive attitude towards the e-learning environment as one conducive to the development of their creativity than the students of the control group.

Conclusion: The positive shift in the experimental group students’ attitude can indicate the effectiveness of the suggested electronic course structure. Thus, it is possible to conclude that using creativity as an organizing principle in an e-learning environment allows educators to introduce the most vital worldwide challenges to students as stimuli for creative tasks and in return, receive their creative solutions.
Genetic parameters for growth traits of Romanian Teleorman Black Head Tsigai sheep
Authors: PELMUS RODICA STEFANIA , PISTOL GINA CECILIA , LAZAR CRISTINA , GROSU HORIA , GRAS MIHAIL ALEXANDRU , GHITA ELENA
Published: November 2023

Estimation of genetic parameters for the local sheep for growth traits is necessary to estimate breeding value of the animals and to determine the breeding objectives. The purpose of this study was to estimate genetic parameters for lamb weight at different age and for average daily weight gain in a local Teleorman Black Head Tsigai population. Records of 545 lambs coming from 210 ewes and 18 rams, were used. Body weight at birth, 30 days and 60 days; the average daily weight gain from birth to 30 days, from 30 to 60 days and from birth to 60 days, were analized. The restricted maximum likelihood method with a model including the maternal genetic effects was used to estimate the genetic parameters. The results revealed that direct and total heritability estimates were low for body weight at 30 days, moderate for birth weight, body weight at 60 days while high for average daily gain from birth to 30 days, 30 days to 60 days and birth to 60 days. The maternal heritability estimates were low for body weight at birth, 30 days and 60 days and moderate for average daily gain from birth to 30 days, 30 days to 60 days and birth to 60 days.
Effect of zinc treatments on lead exposed periparturient bovine lymphocytes in vitro on their proliferation and superoxide dismutase (SOD) expression
Authors: KUMAR MUNEENDRA , KAUR HARJIT , T PHONDBA B , DEKA RIJUSMITA SARMA , CHANDRA GULAB , MANI VEENA , GUPTA NEELAM
Published: November 2023

The study was conducted to observe adverse effects of lead (Pb) treatments and protective effect of zinc on lymphocyte proliferation and to quantify the expression levels of superoxide dismutase (Cu/ZnSOD) genes involved in antioxidant’s defenses in periparturient Karan Fries (Tharparker × Holstein-Friesian) cow. Blood samples were collected from peripartum Karan Fries cow at 30 and 15 days prepartum, at day of calving (0 day) and 15 and 30 days postpartum for estimation of lymphocytes proliferation and SOD expression. A fixed number of cells (2×106) were grown in culture for 72 h with different levels of Pb (10–4, 10–5, 10-6 M) and their adverse effects were counteracted by Zn (50, 55, 60 μM) and analysed for the lymphocyte proliferation (MTT assay) and for the expression level of Cu/ZnSOD using the realtime PCR technique with light upon extension (LUX) fluorogenic primers. Pb dosage had no adverse effect and the overall mean proliferation values indicated that 60μM Zn may be optimum for maximizing lymphocyte proliferation. The Cu/ZnSOD mRNA expression in lymphocytes was higher at higher dosage of Pb in comparison to lower dosage in all the 3 (50, 55, 60 μM) Zn treatments. There was no significant difference at different levels of Zn on SOD expression. Cu/ZnSOD mRNA expression decreased from –30 days to 0 days but increased from 0 to 30 days after calving. The results suggested that the zinc may have an ameliorative effect on lead exposed oxidative stress on lymphocytes proliferation and Cu/ZnSOD mRNA expression through modulation of superoxide dismutase expression
Screening of onion (Allium cepa) genotypes to find out novel resistant source against purple blotch (Alternaria porri)
Authors: CHAUHAN S S A , ISLAM SABINA , PRASAD LAKSHMAN , SINGH SHRAWAN , ELLUR R K , TOMAR B S
Published: November 2023

Purple blotch caused by Alternaria porri (Ellis) Cif., 1930 causes huge losses to bulb crop and seed crop of onion (Allium cepa L.). This is a major disease affecting successful onion production in majority of the onion growing areas. To identify resistant source against purple blotch, 34 onion genotypes with good marketable yield based on field evaluation trial in 2017 and allied species Pusa Soumya were screened under protected conditions during kharif, 2018 at insect proof net house facility of ICAR-Indian Agricultural Research Institute, New Delhi. The pure culture of Alternaria porri, isolated from infected leaf samples of onion crop raised under natural epiphytotic conditions during kharif, 2017. Highest change of disease severity index was observed between 1–2 weeks post inoculation (WPI) while highest disease severity index was recorded at 5 WPI suggesting that preventive measures must be employed as soon as disease symptoms appear in the field. The disease severity index ranged from 0.10–33.33 at 1 WPI, which increased to 9.33–89.33 at 5 WPI. The cultivated allied species Pusa Soumya was identified as novel resistance source with DSI value less than 10.0% at 5 WPI. Four genotypes exhibited moderately susceptible reaction, while 20 genotypes were susceptible and 10 genotypes were highly susceptible. The area under disease progress curve (AUDPC) value ranged from 22.33–240.17. Pusa Soumya had the lowest value and among onion lines Arka Kirtiman was found promising. Three onion genotypes had low relative AUDPC value and can effectively be utilized in resistance breeding programme. The average daily temperature between 20–25°C and relative humidity above 75% was found ideal for disease development.
Effect of planting methods, Mycorrhiza and zinc fertilization on growth and grain yield of pearl millet (Pennisetum glaucum)
Authors: RAMNIWAS  , KUMAWAT S M , OLA GOGRAJ , GAUTAM PRIYANKA , BHUNIA S R , JAKHAR R K , NITHARWAL PRAVEEN KUMAR , CHOUDHARY LAKSHAY , GORA M K , JAT S L , KAKRALIYA MANISH
Published: November 2023

A field experiment was conducted during rainy (kharif) seasons of 2020 and 2021 at research farm of Swami Keshwanand Rajasthan Agriculture University, Bikaner, Rajasthan to study the effect of planting methods, Mycorrhiza and zinc fertilization on growth and productivity of pearl millet [Pennisetum glaucum (L) R.Br.] in hot arid region. The experiment comprised 24 treatments combination having 3 planting methods (S1, flat bed; S2, ridge and furrow; S3, pit technique) and two Mycorrhiza level (M0, control; M1, 8 kg/ha Mycorrhiza basal) in main plot and 4 zinc fertilization practices (Z0, control; Z1, 0.5% ZnSO4 two foliar spray; Z2, zinc sulphate @10 kg/ha basal + 0.5% foliar spray and Z3, zinc sulphate @20 kg/ha basal) in sub plots were laid out in split-plot design and replicated thrice. It may be inferred that in pearl millet pit planting technique (S3), Mycorrhiza (M1) + fertilized with zinc sulphate (Z2) practice gave significantly higher growth parameters, viz. plant stand (141.20 thousand/ha), plant height (171.1 cm), dry matter accumulation, crop growth rate, relative growth rate, chlorophyll content (4.3 mg/g), root dry weight (9.8 g/plant) and number of green leaves/plant (13.9 no./plant), quality parameters, viz. protein content (12.5%) and protein yield (384 kg/ha) in grain, ash (12.1%) and fibre content (44.3%) in stover and grain yield (3.1 t/ha) as compared to all other treatment combinations on pooled basis. The findings emphasize the potential of this technique for enhancing pearl millet productivity and quality in hot arid regions.
Residual effect of INM on mungbean (Vigna radiata) growth, yield uptake and nutrient balance
Authors: N NIRANJAN B , N KISHOR , S PRAKASH S , KUMARASWAMY SUNIL
Published: November 2023

A field experiment was conducted during rainy (kharif) season of 2019–20 and summer season of 2020–21 at Byrasandra village, Karnataka to study the residual effects of integrated nitrogen management (INM) in maize (Zea mays L.) on succeeding mungbean [Vigna radiata (L.) R. Wilczek] growth, yield, and soil properties. The residual effect of treatment involving 75% recommended dose of nitrogen (RDN) + 50% recommended dose of farmyard manure (RD FYM) +25% RDN through vermicompost to kharif maize resulted in significant (P<0.05) taller mungbean plants (25.4 cm), more leaves (16.0), increased pod count (21.7), longer pods (9.7 cm), higher test weight (4.4 g), seed yield (880.4 kg/ha) and haulm yield (1815.8 kg/ha) at harvest compared to the control group. After mungbean harvest, plots treated with 75% recommended dose of nitrogen (RDN) + 50% recommended dose of farmyard manure (RD FYM) + M 25% RDN through vermicompost showed significantly higher uptake of total N, total P, and total K (50.8, 9.3, and 49.1 kg/ha, respectively) compared to the control, improving soil nutrient balance and achieving the highest benefit-cost ratio in Alfisols.
Exploring the physiological efficiencies of promising rice (Oryza sativa) accessions for increasing grain yield
Authors: PANDA BABYRANI , DASH SUSHANTA K , MONDAL SUBHANKAR , SENAPATY JEETENDRA , DASH MANASI , SAMAL KAILASH C , SAHOO CHITTA R , CHAKRABORTY KOUSHIK
Published: November 2023

High grain yield in rice (Oryza sativa L.) is a cumulative contribution of different morphological and physiological traits. However, the selection of high-yielding genotypes based on physiological traits is difficult where a large set of genotypes is used. Therefore, a study was carried out during rainy (kharif) seasons of 2019 and 2020 at research farm of ICAR-National Rice Research Institute, Cuttack, Odisha to assess the physiological efficiency of 211 elite rice genotypes having varying yield potential. The elite genotypes were classified into high, medium, and low categories based on their field performance. The results revealed that 29, 41, 34, 31, 49, 35, 39, 29, and 30 genotypes showing high values for FLA (>51.51 cm2), TCC (>3.99 mg/g fresh weight), PN (>20.79), gs (>0.97), E (>9.03), TB (>15.95 t/ ha), GY (>6.27 t/ha), PR (>0.29 kg/cm), and CS (>42.12 g/stem) respectively. Among them, 3 genotypes i.e. IG-020, IG-211 and IG-010 were identified to be highly efficient in 4 traits, 2 genotypes i.e., IG-044 and IG-186 in 5 traits, and 2 genotypes; IG-008 and IG-161 were found to be superior in 7 traits along with high grain yield. The selection of these genotypes with superior morphological and physiological traits could be beneficial in the breeding programme in terms of increasing yield potential in rice.
Phytochemical screening and antibacterial activity of leaf and fruit extracts of guava (Psidium guajava)
Authors: BHARDWAJ RICHA , NARUKA DEVYANI
Published: November 2023

An experiment was conducted during 2021–23 at IIS (Deemed to be University) Jaipur, Rajasthan to study the antibacterial efficacy of leaf and fruit extracts of guava (Psidium guajava Linn) and to correlate the activity to the phytochemicals present within these plant parts. The study aims to examine primary and secondary metabolites of the extracts qualitatively and quantitatively. The extracts were then used to check the antibacterial efficacy of these plant parts against four bacteria, of which gram-positive were Bacillus subtilis (MTCC-441) and Staphylococcus aureus (MTCC-737) and gram-negative were Escherichia coli (MTCC-739) and Proteus vulgaris (MTCC-426). The concentration of total phenols and total flavonoids was higher in leaves than in fruits. The activity of methanolic extracts of leaves higher than that of fruits highest activity, was seen against E.coli and lowest activity was seen against S. aureus. No activity was recorded against the aqueous extract of both leaf and fruits.
Heterosis and combining ability for nutritional quality in bottle gourd (Lagenaria siceraria)
Authors: BHATT RAJENDRA , RAGHAV MANOJ , BISHT YASHPAL SINGH , KUMAR VINAY , CHAUHAN ARVIND , GAUR AMIT
Published: November 2023

The study was carried during kharif 2021 and zaid 2022 at Vegetable Research Centre of G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand to investigate the nutritional properties of bottle gourd [Lagenaria siceraria (Molina) Standl] across various genotypes and hybrid combinations. Bottle gourd, a versatile crop with nutritional benefits, was analysed for traits like dry matter content, ascorbic acid, reducing sugar, non-reducing sugar, total sugar and total soluble solids. Promising parent genotypes, P6, P1 and P4 were identified based on their per se performance. The hybrid combination P2 × P7 exhibited exceptional results considering relative heterosis, heterobeltiosis and standard heterosis. Parent P3 demonstrated strong general combining ability for several traits. Notably, specific combining ability analysis identified hybrids like P2 × P6, P5 × P6, and P1 × P4 as promising for multiple traits. The prevalence of significant σ2SCA values over σ2GCA values highlighted the dominance gene action's role in governing these traits, suggesting the potential of hybrid breeding for genetic enhancement. In conclusion, the study emphasizes the importance of nutrient quality and presents strategies for harnessing hybrid breeding to improve these traits in bottle gourd.
Kelebek Vanaların Simülasyon Destekli Deney Tasarımı ve Prototip Üretimi
Authors: ÖZKAN Erhan
Published: November 2023

Vana sektöründe tesisatların çabuk açılıp kapanmasını sağlamak ve bu şekilde su ve enerji kaybını azaltmak amacıyla tasarlanan kelebek vanalar isimlerini klape ve milin yerleşim şekillerinden almaktadır. Yaygın olarak kullanılan sfero döküm klape malzemelerin düşük korozyon direncini arttırmak amacıyla rilsan veya epoksi kaplama gibi alternatif yöntemlere başvurulsa da bu opsiyonlarla istenilen korozyon dayanıma ulaşmak mümkün olmamakla birlikte vananın sızdırmazlık fonksiyonlarını da tam olarak yerine getiremediği tespit edilmiştir. Korozyon direncini arttırmak ve sızdırmazlık fonksiyonlarını iyileştirmek amacıyla kullanılan paslanmaz çelik klapeler ise uzun tedarik süreleri, yüksek maliyetleri ve talaşlı imalat işleme zorlukları sebebiyle çok tercih edilememektedir. Bronz klapeler düşük maliyetleri, kısa termin süreleri ve kolay talaşlı imalat özellikleri sebebiyle kritik bir öneme sahiptir. Diğer yandan sfero dökme demir gövde malzemelerinin korozif ortam ile temas eden kısımlarının kauçuk malzeme ile kaplanarak korozyon dirençlerinin arttırılması ve sızdırmazlık fonksiyonlarını yerine getirmesi de sektörde yaygın olarak tercih edilmektedir. Bu çalışmada Lug-Wafer tipi kelebek vanaların sfero dökme demir gövde tasarımı, bronz klapelerin sıcak dövme yöntemi ile üretiminin simülasyon destekli tasarımları ile prototip üretim aşamaları ele alınmış, gövde ve klapenin temas yüzeylerindeki sızdırmazlığı sağlamak amacıyla plastik pres ile EPDM kaplama ölçülerinin ıslak torka etkileri deney tasarımı ile araştırılmış ve sistemin optimum ıslak tork değeri tespit edilmiştir.
Characterization of patients and measures implemented during the pandemic in a high complexity hospital in Argentina: an analysis from a nursing perspective
Authors: Broggi Liliana , Kemmerer Juan , Bandriwskyj Cristina , Fernández Alejandro , Gangoni Cecilia , Laura Víctor Hugo
Published: November 2023

Introduction: the COVID-19 pandemic has left a deep mark all over the world. In the case of Argentina, the situation was no different, and this article seeks to characterize both the patients and the measures implemented in a high complexity Hospital in the country, from a nursing-centered perspective.Methods: an observational, longitudinal and prospective study was designed, which allowed the systematic and continuous collection of information on patients. Data collection techniques used included participant and non-participant observation (through clinical histories and procedures) and interviews with patients.Results: regarding the characteristics of the patients studied, the results were as follows: of the 372 patients analyzed, 140 presented suspicion of COVID-19, while 223 confirmed to be infected. In relation to the gender of the affected patients, it was observed that the percentage of female patients was slightly higher than that of male patients. When analyzing the percentages by age range of the patients with positive results for COVID-19, differences were found among them. Likewise, notable disparities were identified between men and women who suffered from the disease. In the age group 0-99 years, the incidence was higher in men than in women, while this trend was reversed from the age of 61 years onwards.Conclusions: in general terms, the Coronavirus pandemic represents a critical challenge for health institutions, requiring the reorganization of services, spaces and policies. In addition, protocols and procedures should be established to cover all areas of care, as well as to ensure the adequate supply of material and human resources, considering the possibility of leave due to contagion
Car-T cells anti-cd19: a nova estratégia de tratamento na leucemia linfoide aguda infantil de células B
Authors: Scarelli Ana Laura Fernandes , Minante Beatriz Izilda , Zancan Luiza Favaro , Silva Milena Euzébio Rodrigues da , Castro Samara Cristina de , Silva Ana Carolina Costa da
Published: November 2023

A leucemia linfoblástica aguda (LLA) acomete em sua grande maioria crianças e adultos jovens, alcançando em geral com desfechos positivos. Entretanto, há subgrupos de alto risco que apresentam sobrevida significativamente inferior, sendo eles: bebês, pacientes recém-diagnosticados com idade ≥10 anos, contagem de leucócitos ≥50.000/µl, resposta precoce deficiente ou LLA de células T e pacientes com LLA recidivante (HUNGER, 2013). A leucemia linfoblástica aguda de células B recidivante ou refratária está associada a um prognóstico extremamente ruim e continua sendo a principal causa de morte em pacientes pediátricos com leucemia (ZHANG, 2020). Nesse contexto, o uso de Car-t cells (células T do receptor do antígeno quimérico) surge como uma proposta terapêutica inovadora e que apresentou resultados favoráveis, especialmente quando usado contra o antígeno das células B, ou seja, o receptor CD19 (ZHANG, 2020).
Efeitos da liraglutida, análogo de GLP-1, no tratamento da doença de Alzheimer
Authors: Pompermayer Raphaella Gava , Baccarin Camille Stephani , Bortoluci Rafael Grizzo , Mendonça Wellinton da Rocha , Gyotoku Larissa Cocicov
Published: November 2023

A Doença de Alzheimer (DA), descrita por Alois Alzheimer em 1906, caracteriza-se pelo declínio progressivo da memória. Atualmente, os tratamentos aprovados são divididos entre os inibidores da enzima colinesterase e os antagonistas dos receptores de NMDA, com ação somente nos sintomas e incapazes de atuar preventivamente na progressão da doença, sendo necessários tratamentos coadjuvantes (BEHL et al., 2020).
Teoria e prática: componentes indissociáveis da práxis: relato de experiência de estágio no Instituto Nacional de Infectologia
Authors: Barbosa Nathália Del Vecchio França , Dutra Marcelo Motta
Published: November 2023

O objetivo das faculdades de medicina deve ser formar médicos generalistas, altruístas, críticos e reflexivos, capazes de atuar segundo princípios éticos no processo saúde-doença, nos diferentes níveis de atenção. Assim, para que haja um aprendizado idôneo, é necessário envolvimento tanto prático quanto psicossocial do aluno, ou seja, para um estudante de medicina vir a desempenhar o papel de médico, ele necessita ampliar o seu treinamento técnico com atividades que possibilitem o exercício ativo de observação, reflexão, crítica e análise, instrumentos que o médico irá usar como ferramentas no seu trabalho (GERAIS, 2021).
Augmented Retail Marketing: Comprehending Customer Satisfaction by AR Marketing Media
Authors: Suryawijaya Tito , Aqmala Diana
Published: November 2023

This research aims to explore the role of Augmented Reality (AR) as a marketing medium in the context of the post-pandemic retail sector. This research adopts a quantitative approach using the SEM - PLS model. Data was obtained through an online survey using a Google Form-based questionnaire filled out by 100 respondents who had used the AR feature to purchase retail products more than twice. Research findings indicate that AR has great potential to increase customer satisfaction and influence consumer purchasing behavior in the post-pandemic retail sector. The implication of this research is that retail companies can utilize AR technology as an effective marketing tool to improve consumer experience, customer satisfaction and business growth. This research also contributes to the AR-based marketing literature, especially in the post-pandemic retail sector, which can be called "Augmented Retail Marketing". Thus, this research illustrates the important role of AR in shaping the future of retail marketing.
Influence Of The Loan-To-Deposit Ratio On The Return On Assets In Banking Companies Listed On The Indonesian Stock Exchange During The Period 2015-2019
Authors: Maghfuriyah Alfi , Permatasari Ayu Intan , Nurjaya  , Setiawan Teddy
Published: November 2023

In this study, the impact of the Loan to Deposit Ratio (LDR) on Return on Assets (ROA) in banks listed on the Indonesia Stock Exchange from 2015 to 2019 is to be examined. The information used in this study is secondary information. Three companies were collected as research samples after the sample was chosen using a purposive sampling technique from banking data obtained at the Indonesia Stock Exchange over a five-year period. Using documentation as a data collection tool. The traditional assumption test and the simple linear regression test are the analysis methods employed. The Pearson product moment correlation study indicates that the LDR and ROA have a positive and significant association, with a result of 0.748. While the results of simple linear regression analysis show a coefficient of determination (r2) of 0.560, this study's regression model can only account for 56% of the relationship between the independent variable LDR and the dependent variable ROA; the remaining 44% is determined by independent factors or variables unrelated to the study.
The Role Of Workers Organization And Wage Level In Improving Employee Productivity In Electronic Companies In West Java, Indonesia
Authors: Sabil
Published: November 2023

The role of workers' organizations is significant for companies and employees because it impacts wage levels and employee productivity. This study aims to analyze the effect of workers' organizations on wage levels and the effect of workers' organizations and wage levels on work productivity in electronic companies. This research is a type of quantitative research where data is collected by sharing questionnaires with 200 employees who work in the electronics sector in West Java, Indonesia. Data analysis techniques used are descriptive statistics and structural equation modeling (SEM) using PLS.3 software. The results show that Workers' organization directly affects work productivity with significant (0.004 <0.05), Workers' organization directly affects wage level with significance (0.000 <0.05), Wage level directly affects work productivity with insignificant matter (0.986 >0.05), The indirect effect of Workers' organization on Work productivity is through Wage level. P Values are 0.986>0.05, and the impact is not significant.
The Impact of Social Media Promotion on Purchasing Decisions at Jetiga Ala Caffe
Authors: Syamsurizal  , Ka'bah Iffah Fuztu Warobil
Published: November 2023

This research aims to determine the impact of social media promotions on purchasing decisions at Jetiga Ala Cafe. This research uses quantitative methods, with non-probability sampling techniques and sampling using accidental sampling. The population in this study was 188 cafe-style Jetiga Instagram followers with a sample size of 128 respondents used in this study. Based on the data obtained, the calculated t value is 10.196 with a significance of 0.000 <0.05. It can be concluded that social media promotion has a positive and significant effect on purchasing decisions, and based on the coefficient of determination test, the R Square value is 0.452 or 45.2% of the purchasing decision variable. influenced by social media promotions while the rest is influenced by other factors not discussed in this research.
Psychological And Linguistic Factors In The Process Of Teaching The English Vocabulary
Authors: Nasirov Dilshod
Published: November 2023

This article describes the psychological and linguistic factors that determine the process of learning vocabulary. There is also information about the use of words in various situations, performing various exercises using memory, correct pronunciation of words and learning words.
The Influence of e-Promotion, Trust, Convenience, and e-WOM on Purchase Decision with Consumer Behavior as a Mediator
Authors: Prastowo Sugeng Lubar , Nur Muhammad
Published: November 2023

This research examines the influence of e-Promotion, consumer trust, convenience, and e-WOM on the purchase decisions of Shopee consumers, with consumer behavior as a mediating variable. The research methodology employed a quantitative approach, utilizing non-probability purposive sampling with a sample size of 494 respondents. Data analysis was conducted using descriptive and inferential statistics, employing the Smart PLS 3.0 software. The research findings demonstrate that trust, convenience, and e-WOM have a significant direct impact on consumer behavior, whereas e-Promotion does not directly affect consumer behavior. The variables e-Promotion, trust, convenience, and Shopee consumer behavior have a direct and significant influence on purchase decisions, while e-WOM does not directly affect the purchase decisions of Shopee customers. Trust, convenience, and e-WOM have a significant indirect impact on purchase decisions with consumer behavior as a mediating variable, whereas e-Promotion does not have an indirect impact on purchase decisions with consumer behavior as a mediating variable.
Advancing neuroprotection in traumatic brain injury: Maximizing the potential of the nuclear factor erythroid 2-related factor 2/nuclear factor kappa B pathway through insights from animal models
Authors: Kumar Mayank , Singh Shamsher
Published: November 2023

Traumatic brain injury (TBI) is a primary public health concern that can result in significant long-term disability and mortality. Neuroprotection strategies that can mitigate the effects of TBI are urgently needed. The nuclear factor erythroid 2-related factor 2 (Nrf-2)/nuclear factor kappa B (NF-κB) pathway has emerged as a promising TBI neuroprotection target because it regulates inflammation, oxidative stress, and mitochondrial dysfunction. This review summarizes the current preclinical evidence supporting the role of the Nrf-2/NF-κB pathway in TBI and the mechanisms underlying its regulation. Pharmacological and genetic approaches have been used to modulate the pathway in animal models of TBI, resulting in improved functional, histological, and molecular outcomes. The molecular mechanisms underlying the Nrf-2/NF-κB pathway in TBI involve regulating inflammation, oxidative stress, and mitochondrial dysfunction. The future studies should focus on identifying safe and effective agents for modulating this pathway, optimizing dosing regimens, and exploring combination therapies targeting multiple TBI pathways. While preclinical studies have shown promising results, further research is needed to determine the safety and efficacy of modulating the Nrf-2/NF-κB pathway in human TBI patients. Overall, the Nrf-2/NF-κB pathway represents a promising target for neuroprotection in TBI, and further research is needed to translate these preclinical findings into effective treatments for human patients.
Cancer’s initiation and progression: Deciphering the role of genetic and epigenetic alterations
Authors: Taruneshwar Jha, Keshav , A. Chawla Pooja
Published: November 2023

Cancer is a complex disease involving both genetic and epigenetic alterations that drive the transformation of normal cells into malignant ones. In this review, we discuss how genetic mutations and epigenetic changes contribute to cancer initiation and progression. Genetic changes such as mutations, deletions or amplifications of oncogenes and tumor suppressor genes are crucial for the development of most cancers. In addition, epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNAs are also frequently dysregulated in cancer and contribute to its heterogeneity. A better understanding of the interplay between genetic and epigenetic events will shed light on the molecular mechanisms underlying cancer initiation and progression, and may help identify new therapeutic
AVOIDANCE OF DUPLICACY AND COMPELLING CLOUD SECURITY INDIFFERENT CLOUD SITUATIONS
Authors: JIBIN JOY  , Dr. S. Devaraju
Published: November 2023

Data deduplication is necessary for making data smaller and preventing duplication when transferring it. It is often used in cloud computing to increase the amount of data that can be transferred and reduce the amount of memory used. During the deduplication handle, delicate information integrity is safeguarded by means of an encryption approach, sometimes recently being redistributed. The SHA calculation is broadly utilized to store content information. The content is padded to make the security bits. During the deduplication handle, it computes the hash, which consists of hexadecimal, string, and integer information. The term "Hash-based deduplication" technique called hashing used to identify and remove duplicate records. The hash values of content information are important characteristics. Customers who share data with the cloud verify that copies of the data are stored in the cloud, unlike traditional methods of removing duplicate data. Strong limitations on virtualization include restricting the capacity of essential memory and preventing memory hindrance. Memory deduplication finds pages with the same content and combines them into a single information record to move forward performance whereas utilizing less memory. The MPT is used in cloud storage to remove duplicate information and store only one copy for multiple users. To keep cloud information safe, data is mixed up before and during deduplication.
A Swiss digital Delphi study on patient-reported outcomes
Authors: Kerry Matthew J. , Volken Thomas , Biller-Andorno Nikola , Glässel Andrea , Melloh Markus
Published: November 2023

AIMS OF THE STUDY: Health-related quality of life (HRQoL) indicators are patient-reported outcomes (PROs). PROs are defined as any report of the status of a patient’s health condition or health behaviour that comes directly from the patient, without interpretation of the patient’s response by a clinician or anyone else. Despite Swiss national bodies (FOPH, FMH) recognising the potential of PRO measures (PROMs) for improving the health system, no consensus has yet emerged regarding a generic PROM framework or specific domains for practical uptake. The aim of the present digital Delphi study was to generate a consensual Swiss expert opinion on a generic PROM framework, measurement domains and items from a validated instrument (PROMIS [Patient-Reported Outcome Measurement Information System]) as well as on the role and implementation of PROs in the Swiss healthcare system via PRO consensus statements.
METHODS: A 4-round digital Delphi study was conducted among Swiss PRO stakeholders. A total of n = 21 Swiss PROM stakeholders completed round 1 surveys on the PROM framework. During the stakeholder meeting, n = 11 stakeholders completed round 2 and round 3 surveys pertaining to measurement domains and items, respectively. In-meeting key questions and discussion items were extracted, consolidated into statements and subjected to consensus voting in a round 4, post-meeting survey. Consensus was defined as ≥70% agreement.
RESULTS: Pre-meeting, agreement was reached for the tripartite framework of physical, mental and social health (95–100%). During the meeting, agreement was reached on all seven measurement domains of a generic PROM (PROMIS-29), ranging from 80% (Anxiety, Sleep Disturbance) to 100% (Pain Interference, Depression, Ability to Participate in Social Roles). Consensus was also reached for all PROMIS-29 items, with average domain consensus ranging from 83% (Sleep Disturbance, Ability to Participate in Social Roles) to 100% (Depression). Finally, four post-meeting consensus statements regarding PROs in Switzerland reached agreement.
CONCLUSIONS: A Delphi method can help identify areas of need regarding PROMs in Switzerland. The current study identified a generic PROM as a missing quality indicator for the Swiss national health system’s value. A pre-meeting informational briefing, expert presentations and moderation supported three voting rounds to help identify PROMIS-29 as a PROM framework (round 1), measurement domains (round 2) and items (round 3) as a basis for further validation research. The empirical agreement among diverse stakeholders supports broad consensus towards preliminary feasibility of integrating generic PROMs into the Swiss health system based on content relevance.
Statin therapy and gut microbiota
Authors: Chen Peng , Li Kangbao
Published: November 2023

Accumulating studies reveal that statins are associated with distinct gut microbiota profiles. Statin therapy helps maintain gut microbiota homeostasis, reducing the prevalence of gut microbiota dysbiosis and breaking antimicrobial resistance. The possible mechanisms may include improving bile acids metabolism, regulating intestinal innate immunity, and inhibiting cell membrane biosynthesis. Statin treatment might benefit patients with obesity, cardiovascular diseases, malignancies, and immune-related diseases by modulating the compositions and functions of gut microbiota. The altered gut microbiota functions by regulating the host metabolism with microbial-derived metabolites, such as primary and secondary bile acids (BAs) and short-chain fatty acids (SCFAs). Meanwhile, statins can be degraded or modified by the gut microbiota, which may affect the treatment effectiveness in clinic. The addition of probiotics could enhance the effects of statins on hypercholesterolemia and inflammation. Collectively, the interaction between statins and gut microbiota shows great promise for new therapeutic targets and personalized medicine in many diseases, which still need further investigation.
A Review of Statins and COVID-19
Authors: H. Shiu Justin , N. Pham Heather , Singh Navneet , J. Sweidan Alexander
Published: November 2023

Statins are a well-established class of β-Hydroxy β-methylglutaryl Coenzyme A (HMG-CoA) reductase inhibitors that have recently been discussed as a possible therapeutic in COVID-19. The breadth of this chapter reviews the evidence for use of statins alone or in combination with other drugs as treatment for patients hospitalized with moderate to severe COVID-19. Discussion will include a (1) biochemical argument for the role of statins in COVID-19, (2) a systematic literature review of relevant studies to date, and (3) an investigation into early-phase interventional studies. Outcome measures based on all aforementioned relevant studies will be clearly defined and compared.
Statins effects on venous wall in patients with chronic venous disease
Authors: Matei Sergiu-Ciprian
Published: November 2023

The anti-atherogenic, anti-inflammatory, and vasomotor effects of statins on the arteries are well known, but there are no significant literature data about statins treatment effects on veins. This study describes the potential morphological changes that may occur in the venous wall in the case of the patients with chronic venous disease (CVD) which associates atorvastatin treatment for at least two years. The patients were clinically evaluated, and at the same time, a microscopic morphological analysis was performed on surgically removed veins fragments. The obtained results prove an improvement in the CVD prognosis, as well as a better postoperative evolution in these patients, and suggest an improvement in the blood flow in the vasa vasorum from the venous adventitia, as well as a potential phlebotonic and phlebotrophic effect of statins.
Research on Entrepreneurial Intention of College Students Under the Background of Platform Economy
Authors: Cheng Hui
Published: November 2023

The paper reviews the influence of platform economy on the entrepreneurial intention of college students in recent years, and summarizes the factors and mechanisms that affect the entrepreneurial intention of college students under the background of platform economy. Based on the technology acceptance model and the theory of planned behavior, many studies suggest that perceived ease of use, perceived usefulness, entrepreneurial attitude, subjective norms, and perceived behavior control may affect college students' entrepreneurial intention. To encourage college students to participate in platform economy entrepreneurship, educators and policymakers need to pay attention to improving college students' perception of the ease and usefulness of starting a business using digital platforms, cultivating their positive entrepreneurial attitudes, and improving their perceived behavioral control. This may be achieved by providing entrepreneurship education and training, as well as creating an environment that encourages self-drive and self-control.
Ritlecitinib (Litfulo) for Severe Alopecia Areata
Authors:   Editors from The Medical Letter
Published: November 2023

The FDA has approved ritlecitinib (Litfulo – Pfizer), an oral JAK and TEC kinase family inhibitor, for treatment of severe alopecia areata in patients ≥12 years old. Ritlecitinib is the second oral drug to be approved in the US for treatment of severe alopecia areata; baricitinib (Olumiant), a JAK inhibitor, is approved only for use in adults.