bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal frequency of whole body vibration training for improving balance and physical performance in the older people with chronic stroke: A randomized controlled trial
Authors: Wei Ning , Cai Mengying
Published: November 2021

Objective

To explore the optimal frequency of whole-body vibration training for improving the balance and physical performance in older people with chronic stroke.

Design

a single-blind randomized controlled trial.

Setting

Two rehabilitation units in the Wuhan Brain Hospital in China.

Participants

A total of 78 seniors with chronic stroke.

Interventions

Low-frequency group (13 Hz), high-frequency group (26 Hz), and zero-frequency group (Standing on the vibration platform with 0 Hz) for 10 sessions of side-alternating WBV training.

Main measures

The timed-up-and-go test, five-repetition sit-to-stand test, 10-metre walking test, and Berg balance scale were assessed pre- and post-intervention.

Results

Significant time × group interaction effects in five-repetition sit-to-stand test (p = 0.014) and timed-up-and-go test at self-preferred speed (p = 0.028) were observed. The high-frequency group outperformed the zero-frequency group in both five-repetition sit-to-stand test (p = 0.039) and timed-up-and-go test at self-preferred speed (p = 0.024) after 10-sessions training. The low-frequency group displayed only a significant improvement in five-repetition sit-to-stand test after training (p = 0.028). No significant within- or between-group changes were observed in the Berg balance scale and walking speed (p > 0.05). No significant group-difference were found between low-frequency and high-frequency groups. No adverse events were reported during study.

Conclusions

Compared with 13 Hz, 26 Hz had no more benefits on balance and physical performance in older people with chronic stroke.
Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples
Authors: Kojima Kazuhiro , Chambers James K. , Nakashima Ko , Goto-Koshino Yuko , Uchida Kazuyuki
Published: November 2021

Human enteropathy-associated T-cell lymphoma (EATL) is considered to be derived from intraepithelial lymphocytes (IELs); however, the origin of canine intestinal T-cell lymphoma (ITCL) remains unclear. Histological, immunohistochemical, and clonality examinations were performed using endoscopically collected canine duodenum samples of mucosal lesions of chronic enteropathy (CE; 73 cases) and ITCL without transmural neoplastic mass lesions (64 cases). Histopathological examinations revealed the intraepithelial accumulation of lymphocytes (called “intraepithelial lymphocytosis”) in 54/73 CE cases (74%) and the epitheliotropism of neoplastic lymphocytes in 63/64 ITCL cases (98%). Immunohistochemically, IELs in CE with intraepithelial lymphocytosis (IEL+CE) were diffusely immunopositive for CD3, with scattered immunopositivity for CD5, CD8, CD20, and granzyme B (GRB). The percentage of CD8+ in CD3+ IELs was significantly lower in IEL+CE than in CE without intraepithelial lymphocytosis (IEL−CE). Double-labeling immunohistochemistry revealed a high percentage of GRB expression in CD8− IEL among IEL+CE. Among 64 ITCL cases, CD3 was immunopositive in 64 (100%), CD5 in 22 (34%), CD8 in 8 (13%), CD20 in 12 (19%), CD30 in 13 (20%), and GRB in 49 (77%). In CD3+ cells, Ki67 immunopositivity was highest in ITCL, intermediate in IEL+CE, and lower in IEL−CE. A clonal TCR gene rearrangement was detected in 1/19 IEL−CE cases (5%), 15/54 IEL+CE (28%), and 38/58 ITCL (66%). These results indicate that the immunophenotype of canine ITCL (CD8−GRB+) is similar to that of the increased IELs in CE. The high proliferative activity and clonality of T cells in IEL+CE suggest that canine ITCL originates from these IELs, similar to human EATL.
Demographic and Clinical Presentations of Youth using Enhanced Mental Health Services in Six Indigenous Communities from the ACCESS Open Minds Network
Authors: Boksa Patricia , Hutt-MacLeod Daphne , Clair Lacey , Brass Gregory , Bighead Shirley , MacKinnon Aileen , Etter Meghan , Gould Hayley , Sock Eva , Matoush Julie , Rabbitskin Norma , Ballantyne Clifford , Goose Annie , Rudderham Heather , Plourde Vickie , Gordon Maria , Gilbert Lorna , Ramsden Vivian R. , Noel Valerie , Malla Ashok , Iyer Srividya N.
Published: November 2021

Objective

In many Indigenous communities, youth mental health services are inadequate. Six Indigenous communities participating in the ACCESS Open Minds (AOM) network implemented strategies to transform their youth mental health services. This report documents the demographic and clinical presentations of youth accessing AOM services at these Indigenous sites.

Methods

Four First Nations and two Inuit communities contributed to this study. Youth presenting for mental health services responded to a customized sociodemographic questionnaire and presenting concerns checklist, and scales assessing distress, self-rated health and mental health, and suicidal thoughts and behaviors.

Results

Combined data from the First Nations sites indicated that youth across the range of 11–29 years accessed services. More girls/women than boys/men accessed services; 17% identified as LBGTQ+. Most (83%) youth indicated having access to at least one reliable adult and getting along well with the people living with them. Twenty-five percent of youth reported difficulty meeting basic expenses. Kessler (K10) distress scores indicated that half likely had a moderate mental health problem and a fourth had severe problems. Fifty-five percent of youth rated their mental health as fair or poor, while 50% reported suicidal thoughts in the last month. Anxiety, stress, depression and sleep issues were the most common presenting problems. Fifty-one percent of youth either accessed services themselves or were referred by family members. AOM was the first mental health service accessed that year for 68% of youth.

Conclusions

This report is the first to present a demographic and clinical portrait of youth presenting at mental health services in multiple Indigenous settings in Canada. It illustrates the acceptability and feasibility of transforming youth mental health services using core principles tailored to meet communities’ unique needs, resources, and cultures, and evaluating these using a common protocol. Data obtained can be valuable in evaluating services and guiding future service design. Trial registration name and number at Clinicaltrials.gov: ACCESS Open Minds/ACCESS Esprits ouverts, ISRCTN23349893
Suicidal Risk and Adverse Social Outcomes in Adulthood Associated with Child and Adolescent Mental Disorders
Authors: Chartier Mariette J. , Bolton James M. , Ekuma Okechukwu , Mota Natalie , Hensel Jennifer M. , Nie Yao , McDougall Chelsey
Published: November 2021

Objective

The life course of children and adolescents with mental disorders is an important area of investigation, yet it remains understudied. This study provides a first-ever comprehensive examination of the relationship between child and adolescent mental disorders and subsequent suicidal and adverse social outcomes in early adulthood using population-based data.

Methods

De-identified administrative databases were used to create a birth cohort of 60,838 residents of Manitoba born between April 1980 to March 1985 who were followed until March 2015. Unadjusted and adjusted hazard ratios (aHRs) and odds ratios (aORs) were calculated to determine associations between physician-diagnosed mental disorders in childhood or adolescence and a range of adverse early adulthood (ages 18 to 35) outcomes.

Results

Diagnoses of mood/anxiety disorders, attention-deficit hyperactivity disorder, substance use disorder, conduct disorder, psychotic disorder, personality disorders in childhood or adolescence were associated with having the same diagnoses in adulthood. These mental disorder diagnoses in childhood/adolescence were strongly associated with an increased risk of suicidal behaviors and adverse adult social outcomes in adulthood. Similarly, suicide attempts in adolescence conferred an increased risk in adulthood of suicide death (aHR: 3.6; 95% confidence interval [CI]: 1.9-6.9), suicide attempts (aHR: 6.2; CI: 5.0–7.6), social housing use (aHR: 1.7; CI 1.4–2.1), income assistance (aHR: 1.8; CI 1.6–2.1), criminal accusation (aHR: 2.2; CI 2.0–2.5), criminal victimization (aHR:2.5; CI 2.2–2.7), and not completing high school (aOR: 3.1; CI: 2.5–3.9).

Conclusion

Mental disorders diagnosed in childhood and adolescence are important risk factors not only for mental disorders in adulthood but also for a range of early adult adversity. These findings provide an evidence-based prognosis of children's long-term well-being and a rationale for ensuring timely access to mental health services. Better population-level mental health promotion and early intervention for children and adolescents with mental disorders are promising for improving future adult outcomes.
Mental Health Screenings: Practices and Patterns of These and Other Health Screenings in U.S. School Districts
Authors: McCabe Ellen M. , Jameson Beth E. , Strauss Shiela M.
Published: November 2021

Schools’ health screenings can identify students’ missed health concerns. Data from the 2016 School Health Policies and Practices Study were used to determine the proportion of U.S. school districts with physical and mental health screening policies and the proportion that arrange off-campus mental health services. We also examined differences between districts with and without mental health screening policies regarding having physical health screening policies, patterns of these policies, and off-campus mental health service arrangements. Eleven percent of districts had no policies on any of the four physical health screenings assessed, and 87% lacked policies on mental health screenings, the latter especially concerning considering the impact of COVID-19. Districts with policies on mental health screenings were significantly more likely to have body mass index ( p < .01) and oral health ( p < .001) screening policies, and to arrange for off-campus case management ( p < .001), family counseling ( p < .05), group counseling ( p < .01), self-help ( p < .05) and intake evaluation ( p < .05).
The Four Factors of Mind Wandering Questionnaire: Content, Construct, and Clinical Validity
Authors: Lopez Antonella , Caffò Alessandro O. , Tinella Luigi , Bosco Andrea
Published: November 2021

Despite great interest in Mind Wandering, a fully validated questionnaire has been lacking. The Four Factors of Mind Wandering (4FMW) Questionnaire, presented here, meets this demand. First, 80 items were judged for content validity by two panels of experts. Those items that survived this content validity assessment were then tested using exploratory and confirmatory factor analyses on two independent samples of young adults. The 16 resulting items were shown to cluster into four factors (i.e., Failure in social interaction, Failure in interaction with objects, Unawareness, and Inattention). The 4FMW questionnaire showed good reliability, robust structure, and acceptable goodness-of-fit indices, as well as good convergent validity with another Mind Wandering questionnaire. Importantly, the 4FMW questionnaire was able to discriminate between attention-deficit/hyperactivity disorder and obsessive–compulsive disorder symptoms. The 4FMW Questionnaire is a reliable and valid instrument for assessing mind wandering in the young adult population.
Whose Knowledge Is Under the Lens? A Contribution to the Debate Sparked by Clark and Walker's 2011 Research Ethics in Victimization Studies: Widening the Lens
Authors: Nourpanah Shiva , Dawson Myrna
Published: November 2021

The starting point for this commentary is the fruitful exchange of ideas on the ethics of victimization research, published in this journal in 2011, sparked by Clark and Walker's article, “Research Ethics in Victimization Studies: Widening the Lens”. This article provoked a flurry of responses that, taken altogether, provide an illuminating cornerstone for the ethical debates and issues surrounding victimization research. It further inspired us to reflect upon and share our experiences on conducting victimization research at that particular intersection of academia and advocacy that we both occupy. What struck us about this exchange was the absence of any discussion about the role of anti-violence against women advocates, service providers, and organizations in victimization research.
Potential added value of combined DPYD/DPD genotyping and phenotyping to prevent severe toxicity in patients with a DPYD variant and decreased dihydropyrimidine dehydrogenase enzyme activity
Authors: Ockeloen Charlotte W , Raaijmakers Aron , Hijmans-van der Vegt Manon , Bierau Jörgen , de Vos-Geelen Judith , Willemsen Annelieke ECAB , van den Bosch Bianca JC , Coenen Marieke JH
Published: November 2021

Decreased dihydropyrimidine dehydrogenase enzyme activity is associated with severe fluoropyrimidine-associated toxicity. Four clinically relevant variants in the DPYD gene are associated with decreased dihydropyrimidine dehydrogenase activity. However, only ∼25% of DPYD variant carriers show a decreased dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells.

Objective

To investigate if dihydropyrimidine dehydrogenase phenotyping has added value when combined with DPYD genotyping in predicting fluoropyrimidine-related toxicity.

Methods

Retrospective cohort study in which treatment and toxicity data were collected of 228 patients genotyped for four DPYD variants and phenotyped using an ex vivo peripheral blood mononuclear cell assay.

Results

Severe toxicity occurred in 25% of patients with a variant and normal dihydropyrimidine dehydrogenase activity, in 21% of patients without a variant and with decreased dihydropyrimidine dehydrogenase activity, and in 29% of patients without a variant and with normal dihydropyrimidine dehydrogenase activity (controls). The majority of patients with a variant or a decreased dihydropyrimidine dehydrogenase activity received an initial dose reduction (68% and 53% vs 19% in controls) and had a lower mean dose intensity (75% and 81% vs 91% in controls). Fifty percent of patients with a variant and decreased enzyme activity experienced severe toxicity, despite the lowest initial dose and whole treatment dose intensity. They also experienced more grade 4/5 toxicities.

Conclusions

Our results indicate that a combined genotype–phenotype approach could be useful to identify patients at increased risk for fluoropyrimidine-associated toxicity (e.g. patients with a variant and decreased dihydropyrimidine dehydrogenase activity). Because the group sizes are too small to demonstrate statistically significant differences, this warrants further research in a prospective study in a larger cohort.
Men’s Weight Loss Outcomes, Behaviors, and Perceptions in a Self-Directed Commercial Mobile Program: Retrospective Analysis
Authors: Behr Heather , Ho Annabell Suh , Yang Qiuchen , Mitchell Ellen Siobhan , DeLuca Laura , Greenstein Noa , Michaelides Andreas
Published: November 2021

Background

There is little understanding of men’s weight loss outcomes and behaviors in self-directed contexts, such as digital commercial mobile weight management programs. This is an especially pressing question given that men often express disinterest in weight management programs and it is unknown how that manifests in self-directed environments. Aims. Two studies fill this gap by retrospectively observing how men lose weight and engage in weight loss behaviors (Study 1) and their perceptions of improvements and gained knowledge (Study 2) when participating in the full length of a commercial mobile behavior change program called Noom.

Method

In Study 1, repeated-measures linear mixed modeling was used to examine whether weight loss was statistically significant from baseline to 16 weeks and how engagement behaviors predicted weight in a sample of 7,495 male Noom users. In Study 2, 971 male Noom users completed an exploratory survey on the impact of the behavior change education in the program.

Results

In Study 1, men who remained in the full length of the program lost statistically significant weight from baseline to 16 weeks. 63% achieved clinically meaningful (5% or more) weight loss. Engagement in weight loss behaviors on the program predicted the amount of weight lost. In Study 2, men reported learning most about practical application and psychological aspects relating to food and psychology.

Discussion and Conclusion

This is the first study to observe men’s weight loss outcomes, behaviors, and perceptions of what they learned in a self-directed behavior change program. Our findings have important implications for more effective health promotion for the many men who choose to self-direct their weight loss.
Effect of using hybrid nano lubricant on the thermo-hydrodynamic performance of two lobe journal bearings
Authors: Rasoolizadeh Shooroki Abolfazl , Dashti Rahmatabadi Asghar , Zare Mehrjardi Mahdi
Published: November 2021

Due to the wide range of journal bearings applications in the industrial machine, significant efforts have been made by tribology researchers to improve their performance in recent years. Designing new bearings geometry and using lubricants with new chemical compounds including additives are the most common solutions proposed to enhance the performance of journal bearing supports. New advancements in nanotechnology and producing the various types of nano particles have provided the chance of upgrading the properties of commercial lubricants. According to the different effect of nano fluids on the performance of mechanical systems corresponding to their composition, today they are used to achieve different goals in lubrication systems. Upgrading the steady state performance parameters including load carrying capacity, attitude angle, surface cooling and effective viscosity are among the expected results of applying nano lubricant in journal bearings. So, in this study the performance of hydrodynamic two lobe journal bearings lubricated with SiO2-multiwall carbon nano tubes /SAE40 hybrid nano fluid is presented considering the thermal effects. For this purpose, the governing Reynolds and energy equations as well as the equation of heat transfer in bearing shell are modified based on the properties of assumed rotor-bearing system. Then the effects of solid volume fraction of nano particles on the performance of two lobe bearings are studied for different amount of bearing noncircularity. The results indicate that upgrading the solid volume fraction of added nano particle to the SAE40 base oil, enhances the lubricant pressure distribution, load carrying capacity, and lubricant effective viscosity. Further, by increasing the solid volume fraction, the attitude angle and temperature of lubricant and rotor-bearing surfaces experience a decreasing trend. Generally, it's obvious from the results that choosing the appropriate solid volume fraction of SiO2-multiwall carbon nano tubes in hybrid nano oil composition, especially for high value of preload factor, can improve the performance of two lobe bearings.
Can independent regulatory agencies mend Europe’s democracy? The case of the European Medicines Agency’s public hearing on Valproate
Authors: Wood Matthew
Published: November 2021

In 2017, the European Medicines Agency staged the first effort at democratic innovation within transnational European Union institutions directly influencing the transnational regulation of medicines. Alongside its public consultation on epilepsy drug Valproate, European Medicines Agency included a public hearing involving representatives of patients and testimony from those directly affected by the medicines. Using this critical case study, the article argues from a deliberative democratic perspective that although the hearing in many ways exhibited the traditional shortcomings of elite-driven deliberation, it also demonstrated unexpected and surprising deliberative qualities. Based on new quantitative analysis of the hearing using the Discourse Quality Index, and qualitative observation of over 4 hours of footage, the article argues European Medicines Agency’s hearing facilitated equitable access and influence of patients and members of the public who had previously been excluded from decision making on drug distribution. These findings provide important new evidence of the deliberative democratic value of public hearings.
Finding DORI: Using Item Response Theory to Measure Difficulty of Registration in the U.S. and Its Impact on Voters
Authors: Jansa Joshua M. , Motta Matthew , Herrick Rebekah
Published: November 2021

How do states differ in how difficult they make voter registration, and what effect does this have on voters? We propose and validate a new Difficulty of Registration Index (DORI) calculated via an item response theory (IRT) model of five key dimensions of registration (automaticity, portability, deadline, mode, and preregistration) for each state from 2004 to 2020. Since 2004, most states eased registration processes, with Democratic statehouses in racially diverse and young states leading the way. Using CCES data, we find that DORI is associated with increased probability that voters experience problems registering and failing to turnout (in both self-reported and validated turnout data). These effects are pronounced for young voters. This study holds lessons for how restrictive registration procedures can change the shape of the electorate and make it harder to achieve political equality.
Book Review: Opening Doors to Diversity in Leadership
Authors: Paul Amanda
Published: November 2021

Opening Doors to Diversity in Leadership is a hard-hitting look at systemic racism in the workplace. The author provides eye-opening insights into the barriers that those who are marginalized must face when establishing respect and authority in leadership roles. This eight-chapter book examines the plight of four uniquely disadvantaged groups of individuals. These groups include Indigenous populations, women, persons with disabilities, and racialized minorities. These groups were examined with particular interest given the fact that on January 1, 2020, amendments to the Canada Business Corporations Act went into effect and required a greater level of diversity amongst the aforementioned populations (p. 299). Issues within the context of building diversity into the workplace were approached from a triangular perspective, looking at the interplaying dynamics between the psychological, organizational, and cultural/societal dimensions. The author makes it clear that for real and lasting change to take effect, there must be sweeping overhauls within each of the three categories discussed.
Ghost infarct core following endovascular reperfusion: A risk for computed tomography perfusion misguided selection in stroke
Authors: Rodrigues Gabriel M , Mohammaden Mahmoud H , Haussen Diogo C , Bouslama Mehdi , Ravindran Krishnan , Pisani Leonardo , Prater Adam , Frankel Michael R , Nogueira Raul G
Published: November 2021

Background

Computed tomography perfusion (CTP) has been increasingly used for patient selection in mechanical thrombectomy for stroke. However, previous studies suggested that CTP might overestimate the infarct size. The term ghost infarct core (GIC) has been used to describe an overestimation of the final infarct volumes by pre-treatment CTP of >10 ml.

Aim

We sought to study the frequency and predictors of GIC.

Methods

A prospectively collected mechanical thrombectomy database at a comprehensive stroke center between September 2010 and August 2020 was reviewed. Patients were included if they had a successful reperfusion (mTICI2b-3), a pre-procedure CTP, and final infarct volume measured on follow-up magnetic resonance imaging. Uni- and multivariable analyses were performed to identify predictors of GIC.

Results

Among 923 eligible patients (median [IQR] age, 64 [55–75] years; NIHSS, 16 [11–21]; onset to reperfusion time, 436.5 [286–744.5] min), GIC was identified in 77 (8.3%) of the overall patients and in 14% (47/335) of those reperfused within 6 h of symptom onset. The median overestimation volume was 23.2 [16.4–38.3] mL. GIC was associated with higher NIHSS score, larger areas of infarct core and tissue at risk on CTP, unfavorable collateral scores, and shorter times from onset to image acquisition and to reperfusion as compared to non-GIC. Patients with GIC had smaller median final infarct volumes (10.7 vs. 27.1 ml, p < 0.001), higher chances of functional independence (76.2% vs. 55.5%, adjusted odds ratio (aOR) 3.829, 95% CI [1.505–9.737], p = 0.005), lower disability (one-point-mRS improvement, aOR 1.761, 95% CI [1.044–2.981], p = 0.03), and lower mortality (6.3% vs. 15%, aOR 0.119, 95% CI [0.014–0.984], p = 0.048) at 90 days. On multivariable analysis, time from onset to reperfusion ≤6 h (OR 3.184, 95% CI [1.743–5.815], p < 0.001), poor collaterals (OR 2.688, 95% CI [1.466–4.931], p = 0.001), and higher NIHSS score (OR 1.060, 95% CI [1.010–1.113], p = 0.018) were independent predictors of GIC.

Conclusion

GIC is a relatively common entity, particularly in patients with poor collateral status, higher baseline NIHSS score, and early presentation, and is associated with more favorable outcomes. Patients should not be excluded from reperfusion therapies on the sole basis of CTP findings, especially in the early window.
Organizational citizenship behavior in sport: Scale development and validation
Authors: Kim Seungmo , Liu Jingdong , Love Adam , Park Sanghyun
Published: November 2021

The purpose of the current study was to develop a valid and reliable scale to measure organizational citizenship behavior in sport. The current research consisted of a three-stage scale development and validation process: (a) item generation and content validity, (b) construct validity and reliability, and (c) criterion validity. Qualitative and quantitative methods were used to generate and analyze scale items. The results of Exploratory Structural Equation Modeling revealed appropriate goodness-of-fit indexes for the finalized 22-item scale including five dimensions: bonding, encouraging, helping, community service, and extra work. Finally, correlations between each dimension of organizational citizenship behavior and athlete satisfaction and team commitment confirmed the criterion validity. The newly developed organizational citizenship behavior in Sport Scale is expected to help researchers empirically examine the potential relationships between psychological antecedents and identified dimensions of organizational citizenship behavior in sport as well as provide practical guidance to professionals working with athletes.
Varicella pneumonia masquerading as interstitial lung disease: Non-specific interstitial pneumonitis
Authors: Bhat Rama , Kamath Navaneeth S , Rao Raghavendra , Sneha S
Published: November 2021

Varicella-zoster virus infection also known as chickenpox is a common clinical entity especially among unvaccinated children and adults. It is said that severity increases as the age increases. Approximately 5%–15% of adult varicella can produce pulmonary manifestations. Varicella pneumonitis occurs especially in at-risk individuals like pregnant, smokers, chronic lung diseases like chronic obstructive pulmonary disease, and immunosuppression. The authors describe a case of severe varicella pneumonitis in a healthy immunocompetent middle-aged woman which posed a great diagnostic challenge. The authors also want to highlight that how a common disease can pose a diagnostic dilemma and present with life-threatening organ failure and timely intervention is needed to prevent mortality.
The role of knowledge, attitudes, and health workers’ behavior in COVID19 pandemic preparedness at Aceh Pidie Jaya District, Indonesia
Authors: Yanti Budi , Armita Nurdarlila , Zakaria Iskandar
Published: November 2021

Introduction

Health workers are at high risk of contracting the disease because they are at the forefront of assisting COVID19 patients. Globally, Indonesia has the worst death toll of health workers. Many previous studies have shown the differences in knowledge, attitudes, and behavior of health workers in handling with the COVID19 pandemic. This study aims to asses the role of knowledge, attitudes, and health workers' preparedness during the COVID-19 pandemic in Aceh Pidie Jaya District.

Methods

A cross-sectional study and the data were collected by distributing online questionnaires about knowledge, attitudes, behavior, and preparedness related to the COVID-19 at 12 Pidie Jaya District health centers. The knowledge, behavior, and preparedness parameters used Guttman and Likert scales to measure the workers' attitudes. Chi-square test was used to evaluate the relationship between knowledge, attitudes, behavior, and preparedness.

Results

In this study, 377 health workers were selected, the majority of respondents' education level was diploma, level 3 (257, 76.3%), and one-third of the respondents did not attend training. There are 197 (58.5%) respondents who had good knowledge, 177 (52.5%) positive attitudes, 283 (84%) good behavior, and 173 (51, 3%) well prepared. Furthermore, good knowledge, positive attitude, and good behavior had a significant correlation statistically with well prepared during the pandemic (p < 0.05).

Discussion

Most of the health workers in Aceh Pidie Jaya have good knowledge, positive attitudes, and good behavior that create adequate preparedness. Even though training is still very limited, educational attainment would remain the cornerstone for preparedness to encounter COVID-19.
Espionage, Adultery, and Witchcraft: Rumor and Imagination Transplant in the Anti-Catholic Persecution of Late Ming China
Authors: Xuliang Sun
Published: November 2021

Catholic missionaries have suffered numerous persecutions since their arrival in Ming China in 1583. Rumors which functioned either as the causation or as the main content of the accusations against Catholic missionaries played a vital role in the rise and development of anti-Catholic movements in Late Ming China. In terms of the contents, these rumors can be divided into three categories: rumors accusing missionaries of conducting espionage activities in China, rumors accusing missionaries of having sexual misconducts with local women, and rumors accusing missionaries of performing sorceries. Besides, different images of missionaries were created in these rumors, including spies dispatched by Portuguese from Macau, human traffickers, children-eaters, adulterers, sorcerers, and heretics. The initiation, circulation, and manipulation of these rumors and the construction of different negative images of Catholic missionaries are not only products of the imagination transplant mechanism, but also attempts of anti-Catholic opponents to “stigmatize” missionaries and construct the heterodox-teaching image of Catholicism.
Preventiometer, a Novel Wellness Assessment Device, Used With Healthy Volunteers: A Phase 2 Study
Authors: Nanda Sanjeev , Chon Tony Y. , Mahapatra Saswati , Lindeen Stephanie A. , Fischer Karen M. , Krüger Markus , Schierwater Bernd , Schmidt Carsten O. , Wahner-Roedler Dietlind L. , Bauer Brent A.
Published: November 2021

Background

We previously reported on a pilot study to assess the incorporation of a novel wellness assessment device, the Preventiometer (iPEx5 GmbH, Greifswald, Germany), into an academic medical practice. The present follow-up study expands on those data and evaluates the acceptability of the assessment process in a larger sample population.

Objective

The aim of this study was to evaluate participant satisfaction with the Preventiometer wellness assessment.

Methods

A total of 60 healthy volunteers participated. Each participant underwent a comprehensive wellness assessment with the Preventiometer and received data from more than 30 diagnostic tests. A 32-question survey (with a numeric rating scale from 0 to 10) was used to rate the wellness assessment tests and participants’ impressions of the wellness assessment.

Results

Each assessment had a significantly higher rating than 7 ( P < .001), and the majority of participants agreed or strongly agreed that they were satisfied (98.3%), and they strongly agreed that they were engaged the entire time (93.2%), and liked the instant test results feature of the Preventiometer device (93.2%).

Conclusion

This study confirms findings from our previous pilot study regarding the feasibility of the Preventiometer as a wellness assessment tool. The study further demonstrated that 98% of participants were satisfied with the assessment and that all of them would recommend it to others.
Modeling Millennials’ Adoption Intentions of E-banking: Extending UTAUT with Perceived Risk and Trust
Authors: Mer Akansha , Virdi Amarpreet Singh
Published: November 2021

The rationale of this research is to analyse and observe the factors that persuade millennials’ acceptance, adoption and usage of e-banking services in the banking industry in India. This research used primary data gathered from millennials in India. The sampling technique used is judgment sampling. Statistical analysis is conducted using structural equation modeling. The study’s findings indicate that effort expectancy, trust, social influence, performance expectancy and perceived risk are the factors that impinge on millennials’ behavioural intention of e-banking. The study suggests that effort expectancy, trust, social influence and performance expectancy posit a positive association with the e-banking behavioural intention of millennials in India. On the contrary, perceived risk is in a negative association with the e-banking behavioural intention of the millennials. The study makes a novel contribution to the literature with reference to India, being a pioneer attempt to investigate the factors that affect e-banking acceptance by millennials in Indian banks by extending UTAUT with perceived risk and trust. The present study contributes to the literature on e-banking adoption in India by highlighting that trust plays a crucial role in Indian millennials’ intention to adopt e-banking technology in high-power distance country like India.
Patient-Reported Outcomes After a Modified Albee Procedure
Authors: Bevan Patrick J. , Farrow Lutul D. , Warren Jared , Hooper Perry O. , Kroneberger Elisabeth , Andrish Jack T.
Published: November 2021

Background:

Trochlear dysplasia (TD) is a recognized condition that can become a risk factor for patellofemoral instability. A modified Albee osteotomy procedure using a trapezoidal-shaped wedge to elevate the lateral wall of the trochlea can be used with the goal of preventing further dislocation. However, outcomes studies are lacking, and scores on patient-reported outcome measures (PROMs) are largely unknown.

Purpose/Hypothesis:

The purpose of this study was to identify PROM scores for the Kujala Anterior Knee Pain Scale (AKPS), International Knee Documentation Committee (IKDC), Activity Rating System (ARS), and 100-point pain visual analog scale (VAS) for patients having undergone the modified Albee osteotomy. The hypothesis was that patients will have acceptable pain and function at mid- to long-term follow-up.

Study Design:

Case series; Level of evidence, 4.

Methods:

From 1999 to 2017, a total of 46 consecutive patients (49 knees) underwent a modified Albee procedure by a single surgeon at a single health care system. These 46 patients were contacted and asked to complete the AKPS, IKDC, ARS, and pain VAS. Additional demographic information was obtained via chart review. Frequencies and rates for categorical variables and means and standard deviations for continuous variables of the demographics and PROM scores were calculated.

Results:

PROM scores were obtained in 28 (30 knees; 61%) of the 46 patients. At minimum follow-up of 82 months, the mean scores were 78.5 ± 18.2 for AKPS, 61.2 ± 11.4 for IKDC, 5.2 ± 5.3 for ARS, and 24.4 ± 28.7 for VAS pain. Notably, only 1 of the 28 patients reported a patellofemoral dislocation since surgery, and this was an isolated incident without further instability.

Conclusion:

A modified Albee trochlear osteotomy can be a successful adjunctive procedure to prevent recurrent patellar dislocations in patients with mild TD. However, owing to the loss of one-third of patient follow-up scores and the absence of baseline function scores in this study, the procedure deserves further investigation as a way to address a particularly difficult dilemma for a select subset of patients with patellofemoral instability.
“If We Don’t Do It, Nobody Is Going to Talk About It”: Indigenous Students Disrupting Latinidad at Hispanic-Serving Institutions
Authors: Kovats Sánchez Gabriela
Published: November 2021

Hispanic and Latinx are terms that conflate ethnicity, race, and nationality and complicate our ability to generalize what it means for Hispanic-serving institutions (HSIs) to serve such a diverse student population. Latinidad has also privileged mestizo narratives that obscure enduring colonialities of power and perpetuate the invisibility of Indigenous Peoples. Conceptually framed by Critical Latinx Indigeneities, this study documents the testimonios of 10 Indigenous Mixtec/Ñuu Savi, Zapotec, and Nahua students at HSIs in California. I highlight issues of racialization and Indigenous misrepresentation within Latinx-centered curricula and programming and the ways participants engaged in fugitive acts of learning to claim new forms of visibility on campus. The findings raise important implications for HSIs, including Latinx programming that disrupts colonial perspectives and creates more nuanced understandings of diasporic Indigeneity within Latinx communities.
Not All Disadvantages Are Equal: Racial/Ethnic Minority Students Have Largest Disadvantage Among Demographic Groups in Both STEM and Non-STEM GPA
Authors: Whitcomb Kyle M. , Cwik Sonja , Singh Chandralekha
Published: November 2021

An analysis of institutional data to understand the outcome of obstacles faced by students from historically disadvantaged backgrounds is important in order to work toward promoting equity and inclusion. We use 10 years of institutional data at a large public research university to investigate the grades earned by students categorized on four demographic characteristics: gender, race/ethnicity, low-income status, and first-generation college student status. We find that on average across all years of study, underrepresented minority (URM) students experience a larger penalty to their mean overall and STEM GPA than even the most disadvantaged non-URM students. Moreover, the URM students with additional disadvantages due to socioeconomic status or first-generation college status were further penalized in their average GPA. These inequitable outcomes point to systemic inequities in higher education for students with historically disadvantaged backgrounds and the need to dismantle institutional inertia to support them.
ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1
Authors: Zhong Wenbin , Cao Xiuye , Pan Guoping , Niu Qun , Feng Xiaoqin , Xu Mengyang , Li Mingchuan , Huang Yu , Yi Qing , Yan Daoguang
Published: November 2021

Human T-cell leukemia virus 1 (HTLV-1) causes adult T-cell leukemia (ATL), but the mechanism underlying its initiation remains elusive. In this study, ORP4L was expressed in ATL cells but not in normal T-cells. ORP4L ablation completely blocked T-cell leukemogenesis induced by the HTLV-1 oncoprotein Tax in mice, whereas engineering ORP4L expression in T-cells resulted in T-cell leukemia in mice, suggesting the oncogenic properties and prerequisite of ORP4L promote the initiation of T-cell leukemogenesis. For molecular insight, we found that loss of miR-31 caused by HTLV-1 induced ORP4L expression in T-cells. ORP4L interacts with PI3Kδ to promote PI(3,4,5)P3 generation, contributing to AKT hyperactivation; NF-κB–dependent, p53 inactivation-induced pro-oncogene expression; and T-cell leukemogenesis. Consistently, ORP4L ablation eliminates human ATL cells in patient-derived xenograft ATL models. These results reveal a plausible mechanism of T-cell deterioration by HTLV-1 that can be therapeutically targeted.
Total NT-proBNP, a novel biomarker related to recurrent atrial fibrillation
Authors: Staszewsky Lidia , Meessen Jennifer M. T. A. , Novelli Deborah , Wienhues-Thelen Ursula-Henrike , Disertori Marcello , Maggioni Aldo P. , Masson Serge , Tognoni Gianni , Franzosi Maria Grazia , Lucci Donata , Latini Roberto
Published: November 2021

Background

Novel circulating biomarkers may help in understanding the underlying mechanisms of atrial fibrillation (AF), a challenge for AF management and prevention of cardiovascular (CV) events. Whether glycosylation affects the prognostic value of N-terminal pro-B type natriuretic peptide (NT-proBNP) in AF is still unknown.

Objectives

To test how deglycosylated total NT-proBNP, NT-proBNP and a panel of biomarkers are associated with: (1) recurrent AF, (2) first hospitalization for CV reasons.

Methods

A total of 382 patients of the GISSI-AF trial in sinus rhythm with a history of AF, echocardiographic variables, total NT-proBNP, NT-proBNP and nine additional biomarkers [Total N-terminal pro-B type natriuretic peptide (Total NT proBNP), N-terminal pro-B type natriuretic peptide (NTproBNP), Angiopoietin 2 (Ang2), Bone morphogenic protein-10 (BMP10), Dickkopf-related protein-3 (DKK3), Endothelial cell specific molecule-1 (ESM1), Fatty acid-binding protein 3 (FABP3), Fibroblast growth factor 23 (FGF23), Growth differentiation factor-15 (GDF15), Insulin-like growth factor-binding protein-7 (IGFBP7) and Myosin binding protein C3 (MYPBC3)]. were assayed at baseline, 6 and 12 months under blind conditions in a laboratory at Roche Diagnostics, Penzberg, Germany. The associations between circulating biomarkers and AF at the 6- and 12-month visits, and their predictive value, were assessed in multivariable models with logistic regression analysis and Cox proportional hazards regression analysis. Biomarkers associations were modelled for 1SD increase in their level.

Results

Over a median follow-up of 365 days, 203/382 patients (53.1%) had at least one recurrence of AF and 16.3% were hospitalized for CV reasons. Total NT-proBNP, NT-proBNP, Ang2 and BMP10 showed the strongest associations with ongoing AF. Natriuretic peptides also predicted recurrent AF (total NT-proBNP: HR:1.19[1.04–1.36], p = 0.026; NT-proBNP: HR:1.19[1.06–1.35], p = 0.016; Ang2: HR:1.07[0.95–1.20], p = 0.283; BMP10: HR:1.09[0.96–1.25], p = 0.249) and CV hospitalization (total NT-proBNP: HR:1.57[1.29–1.90], p < 0.001 1.63], p = 0.097).

Conclusions

The association of total NT-proBNP with the risk of AF first recurrence was similar to that of NT-proBNP, suggesting no influence of glycosylation. Analogous results were obtained for the risk of first hospitalization for CV reasons. Natriuretic peptides, Ang2 and BMP10 were associated with ongoing AF. Findings from the last two biomarkers point to a pathogenic role of cardiac extracellular matrix and cardiomyocyte growth in the myocardium of the right atrium and ventricle.
Unrecognized concomitant ventricular septal rupture and left ventricular aneurysm 10 months after myocardial infarction in a patient presenting with chronic heart failure
Authors: Kawamura Masashi , Monta Osamu , Shibata Kana , Tsutsumi Yasushi
Published: November 2021

Background

We report a rare case of concomitant inferior left ventricular aneurysm and ventricular septal rupture in a patient presenting with chronic heart failure.

Case presentation

An 81-year-old man suffered from congestive heart failure. His symptoms were alleviated by medical management; however, heart failure symptoms continued according to the New York Heart Association Functional Classification III. Ten months after presentation, ventricular septal rupture was diagnosed using echocardiography. The left ventricular aneurysm was also complicated. Surgical repair of the ventricular septal rupture and left ventricular aneurysm was successfully performed. The ventricular septal rupture consisted of multiple holes, and the infarcted myocardium had already progressed to firm, fibrotic scar tissue. We closed the ventricular septal rupture with a small bovine pericardial patch and performed an aneurysmectomy with a liner technique.

Conclusions

Cases of ventricular septal rupture can have various clinical scenarios, and treatment should be optimized for each patient, especially with respect to the timing of surgery.
Prevalence of potentially harmful multidrug interactions on medication lists of elderly ambulatory patients
Authors: Anand Tara V. , Wallace Brendan K. , Chase Herbert S.
Published: November 2021

Background

It has been hypothesized that polypharmacy may increase the frequency of multidrug interactions (MDIs) where one drug interacts with two or more other drugs, amplifying the risk of associated adverse drug events (ADEs). The main objective of this study was to determine the prevalence of MDIs in medication lists of elderly ambulatory patients and to identify the medications most commonly involved in MDIs that amplify the risk of ADEs.

Methods

Medication lists stored in the electronic health record (EHR) of 6,545 outpatients ≥60 years old were extracted from the enterprise data warehouse. Network analysis identified patients with three or more interacting medications from their medication lists. Potentially harmful interactions were identified from the enterprise drug-drug interaction alerting system. MDIs were considered to amplify the risk if interactions could increase the probability of ADEs.

Results

MDIs were identified in 1.3 % of the medication lists, the majority of which involved three interacting drugs (75.6 %) while the remainder involved four (15.6 %) or five or more (8.9 %) interacting drugs. The average number of medications on the lists was 3.1 ± 2.3 in patients with no drug interactions and 8.6 ± 3.4 in patients with MDIs. The prevalence of MDIs on medication lists was greater than 10 % in patients prescribed bupropion, tramadol, trazodone, cyclobenzaprine, fluoxetine, ondansetron, or quetiapine and greater than 20 % in patients prescribed amiodarone or methotrexate. All MDIs were potentially risk-amplifying due to pharmacodynamic interactions, where three or more medications were associated with the same ADE, or pharmacokinetic, where two or more drugs reduced the metabolism of a third drug. The most common drugs involved in MDIs were psychotropic, comprising 35.1 % of all drugs involved. The most common serious potential ADEs associated with the interactions were serotonin syndrome, seizures, prolonged QT interval and bleeding.

Conclusions

An identifiable number of medications, the majority of which are psychotropic, may be involved in MDIs in elderly ambulatory patients which may amplify the risk of serious ADEs. To mitigate the risk, providers will need to pay special attention to the overlapping drug-drug interactions which result in MDIs.