bluuebunny/crossref_metadata_2025 huggingface dataset:
Climate change and malaria: some recent trends of malaria incidence rates and average annual temperature in selected sub-Saharan African countries from 2000 to 2018
Authors: Leal Filho Walter , May Julia , May Marta , Nagy Gustavo J.
Published: August 2023

Background

Malaria is still a disease of massive burden in Africa, also influenced by climate change. The fluctuations and trends of the temperature and precipitation are well-known determinant factors influencing the disease’s vectors and incidence rates. This study provides a concise account of malaria trends. It describes the association between average temperature and malaria incidence rates (IR) in nine sub-Saharan African countries: Nigeria, Ethiopia, South Africa, Kenya, Uganda, Ghana, Mozambique, Zambia and Zimbabwe. The incidence of malaria can vary both in areas where the disease is already present, and in regions where it is present in low numbers or absent. The increased vulnerability to the disease under increasing average temperatures and humidity is due to the new optimal level for vector breeding in areas where vector populations and transmission are low, and populations are sensitive due to low acquired immunity.

Methods

A second source trend analysis was carried out of malaria cases and incidence rates (the number of new malaria cases per 1000 population at risk per year) with data from the World Health Organization (WHO) and average annual mean temperature from 2000 to 2018 from the World Bank’s Climate Change Knowledge Portal (CCKP). Additionally, descriptive epidemiological methods were used to describe the development and trends in the selected countries. Furthermore, MS Excel was chosen for data analysis and visualization.

Results

Findings obtained from this article align with the recent literature, highlighting a declining trend (20–80%) of malaria IR (incidence rate) from 2000 to 2018. However, malaria IR varies considerably, with high values in Uganda, Mozambique, Nigeria and Zambia, moderate values in Ghana, Zimbabwe, and Kenya, and low values in South Africa and Ethiopia in 2018. Evidence suggests varying IRs after average temperature fluctuations in several countries (e.g., Zimbabwe, Ethiopia). Also, an inverse temperature-IR relationship occurs, the sharp decrease of IR during 2012–2014 and 2000–2003, respectively, occurred with increasing average temperatures in Ghana and Nigeria. The decreasing trends and fluctuations, partly accompanying the temperature, should result from the intervention programmes and rainfall variability. The vulnerability and changing climate could arrest the recent trends of falling IR.

Conclusion

Thus, malaria is still a crucial public health issue in sub-Saharan Africa, although a robust decreasing IR occurred in most studied countries.
Patients ‘ perspectives on bone replacement materials in a German university hospital setting
Authors: Soares Ana Prates , Fischer Heilwig , Orassi Vincenzo , Heiland Max , Checa Sara , Schmidt-Bleek Katharina , Rendenbach Carsten
Published: August 2023

Background

The challenges in developing new bone replacement materials and procedures reside not solely in technological innovation and advancement, but also in a broader patient therapy acceptance. Therefore, there is a need to assess patients’ perspectives on the materials and approaches in use as well as the ones being developed to better steer future progress in the field.

Methods

A self-initiating cross-sectional questionnaire aimed at people seeking treatment at the university hospital environment of Charité Berlin was formulated. The survey contained 15 close-ended questions directed toward the participant’s epidemiological profile, willingness, acceptance, and agreement to receive different bone replacement materials, as well as, worries about the post-surgical consequences that can arise post bone replacement surgery. Descriptive and categorical analysis was performed to compare the observed number of subjects, their profile and each related response (Pearson’s chi-square test or Fischer’s test, p < 0.05).

Results

A total of 198 people engaged with the questionnaire, most of them Millennials. Overall patients trusted scientifically developed biomaterials designed for bone replacement, as demonstrated by their willingness to participate in a clinical trial, their acceptance of alloplastic materials, and the none/few worries about the presence of permanent implants. The data revealed the preferences of patients towards autologous sources of cells and blood to be used with a biomaterial. The data have also shown that both generation and education influenced willingness to participate in a clinical trial and acceptance of alloplastic materials, as well as, worries about the presence of permanent implants and agreement to receive a material with pooled blood and cells.

Conclusion

Patients were open to the implantation of biomaterials for bone replacement, with a preference toward autologous sources of blood and/or tissue. Moreover, patients are concerned about strategies based on permanent implants, which indicates a need for resorbable materials. The knowledge gained in this study supports the development of new bone biomaterials.
The Tunisian experience of participatory health governance: the Societal Dialogue for Health (a qualitative study)
Authors: Ben Mesmia Hela , Rajan Dheepa , Bouhafa Chtioui Rim , Koch Kira , Jaouadi Imen , Aboutaleb Hala , De Courcelles Sana , Atmani Louisa , Pujos Blanche , Mtiraoui Ali
Published: August 2023

Background

Tunisia has been engaged in the Societal Dialogue (SD) for Health process since 2012, a participatory health governance process aimed at bringing in people’s voice into health policy-making. Its first success was the recently released National Health Policy 2030. This paper aims to document the SD process and to bring out the lessons learned to inspire other countries.

Methods

This study was based essentially on a qualitative analysis of semi-structured interviews with citizen jury members and health experts that took place from May to September 2018. The qualitative analysis adopted an inductive-deductive approach according to a cross-matrix between the themes of the interview of the two groups of interviewees.

Results

The qualitative analysis of the data highlighted that the Societal Dialogue created a health democracy dynamic with inclusive dialogue spaces for the population, communities, and civil society to participate in health system design. It constituted a multi-actor and multidisciplinary coordination platform to increase consensus building among actors. Initial government support and high levels of volunteer commitment allowed the process to achieve a certain level of sustainability. However, this process faced and still faces many challenges such as overreliance on volunteers; a crisis of trust; political instability and the lack of an effective communication strategy. These challenges negatively influence the policy uptake of recommendations made by the Societal Dialogue for Health.

Conclusion

The Tunisian societal dialogue experience highlights both the successes and challenges of a structured participatory platform, as well as the effort and perseverance it takes to keep such a process functional and relevant. A key lesson from this study is that this model of participatory health governance eventually reaches a stage where population, community, and civil society participation needs to be more institutionalized within the government routine so that it can credibly feed into health policy review processes and inform decision-makers on a regular basis.
Economic evaluations of non-communicable diseases conducted in Sub-Saharan Africa: a critical review of data sources
Authors: Hollingworth Samantha A , Leaupepe Glory-Anne , Nonvignon Justice , Fenny Ama Pokuaa , Odame Emmanuel A. , Ruiz Francis
Published: August 2023

Background

Policymakers in sub-Saharan Africa (SSA) face challenging decisions regarding the allocation of health resources. Economic evaluations can help decision makers to determine which health interventions should be funded and or included in their benefits package. A major problem is whether the evaluations incorporated data from sources that are reliable and relevant to the country of interest. We aimed to review the quality of the data sources used in all published economic evaluations for cardiovascular disease and diabetes in SSA.

Methods

We systematically searched selected databases for all published economic evaluations for CVD and diabetes in SSA. We modified a hierarchy of data sources and used a reference case to measure the adherence to reporting and methodological characteristics, and descriptively analysed author statements.

Results

From 7,297 articles retrieved from the search, we selected 35 for study inclusion. Most were modelled evaluations and almost all focused on pharmacological interventions. The studies adhered to the reporting standards but were less adherent to the methodological standards. The quality of data sources varied. The quality level of evidence in the data domains of resource use and costs were generally considered of high quality, with studies often sourcing information from reliable databases within the same jurisdiction. The authors of most studies referred to data sources in the discussion section of the publications highlighting the challenges of obtaining good quality and locally relevant data.

Conclusions

The data sources in some domains are considered high quality but there remains a need to make substantial improvements in the methodological adherence and overall quality of data sources to provide evidence that is sufficiently robust to support decision making in SSA within the context of UHC and health benefits plans. Many SSA governments will need to strengthen and build their capacity to conduct economic evaluations of interventions and health technology assessment for improved priority setting. This capacity building includes enhancing local infrastructures for routine data production and management. If many of the policy makers are using economic evaluations to guide resource allocation, it is imperative that the evidence used is of the feasibly highest quality.
SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
Authors: Bastos Nuno , Castaldo Stéphanie A. , Adem Bárbara , Machado José C. , Melo Carlos A. , Melo Sonia A.
Published: August 2023

Background

Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males and females in the US, only lagging behind lung cancer. The lethality of PDAC is driven by late diagnosis and inefficient therapies. The complex biology of PDAC involves various cellular components, including exosomes that carry molecular information between cells. Thus, recipient cells can be reprogrammed, impacting tumorigenesis. Rab27a is a GTPase responsible for the last step of exosomes biogenesis. Hence, dissecting the mechanisms that regulate the expression of Rab27a and that control exosomes biogenesis can provide fundamental insights into the molecular underpinnings regulating PDAC progression.

Methods

To assess the mechanism that regulates Rab27a expression in PDAC, we used PDAC cell lines. The biological significance of these findings was validated in PDAC genetically engineered mouse models (GEMMs) and human samples.

Results

In this work we demonstrate in human PDAC samples and GEMMs that Rab27a expression decreases throughout the development of the disease, and that Rab27a knockout promotes disease progression. What is more, we demonstrate that Rab27a expression is epigenetically regulated in PDAC. Treatment with demethylating agents increases Rab27a expression specifically in human PDAC cell lines. We found that SMC3, a component of the cohesin complex, regulates Rab27a expression in PDAC. SMC3 methylation is present in human PDAC specimens and treatment with demethylating agents increases SMC3 expression in human PDAC cell lines. Most importantly, high levels of SMC3 methylation are associated with a worse prognosis in PDAC. Mechanistically, we identified an enhancer region within the Rab27a gene that recruits SMC3, and modulates Rab27a expression.

Conclusion

Overall, we dissected a mechanism that regulates Rab27a expression during PDAC progression and impacts disease prognosis.
The AIDS and Cancer Specimen Resource (ACSR): HIV malignancy specimens and data available at no cost
Authors: Silver Sylvia , Schmelz Monika
Published: August 2023

The goal of the AIDS and Cancer Specimen Resource (ACSR) is to play a major role in the advancement of HIV/AIDS cancer-related research/treatment by providing richly annotated biospecimens and data to researchers at no cost. The ACSR acquires, stores, and equitably distributes these samples and associated clinical data to investigators conducting HIV/AIDS-related research, at no costs. Currently, it is the only biorepository of human biospecimens from people with HIV and cancer available to eligible researchers globally who are studying HIV associated malignancies.

This review describes the history and organizational structure of the ACSR, its types of specimens in its inventory, and the process of requesting specimens. In addition, the review provides an overview of research that was performed over the last 5 years with its support and gives a summary of important new findings acquired by this research into the development of cancers in people with HIV, including both Aids-related and non-Aids-related malignancies.
Rescue therapy with an albuvirtide-based antiretroviral regimen in an HIV-infected child with multidrug resistance and multiple opportunistic infections: a case report
Authors: Tang Wei , Song Xiao-yun , Cao Jing , Liu Chun , Zheng Fang
Published: August 2023

Background

Managing multidrug-resistant (MDR) HIV infections in children is particularly challenging due to the lack of experience with new drugs in the pediatric setting. Second-line albuvirtide (ABT) with an optimized antiretroviral background therapy was approved for adults and adolescents after first-line treatment failure. This paper describes the treatment outcomes and adverse effects of an ABT-based dual-active antiretroviral treatment regimen in a child with MDR HIV strains.

Case presentation

A 13 year-old Chinese female patient infected with MDR HIV strains showed a decrease in viral load (from 4.48 log10 to 1.73 log10) and an increase in CD4 + T cells (from 15 to 308 cells/µl) after 12 months of treatment with an ABT-based antiretroviral regimen. The child showed no relevant drug-related adverse reactions.

Conclusions

The case reported here could suggest that an ABT-based antiretroviral therapy might be beneficial and without relevant toxicity in children with MDR HIV. Infectiologists specializing in managing HIV should be prepared to manage an increasing number of children with MDR HIV. ABT might be a new treatment option for MDR HIV infection in children.
Robotic-assisted systems for the safe and reliable treatment of femoral neck fractures: retrospective cohort study
Authors: Wang Xiaofei , Zhang Yaxin , Lou Linbing , Xu Lei , Fei Wenyong , Dai Jihang , Wang Jingcheng
Published: August 2023

Background

Robots are being used in a wide range of surgical procedures. However, in clinical practice, the efficacy of orthopedic robotic-assisted treatment of femoral neck fractures is still poorly reported, particularly in terms of screw placement accuracy, femoral neck fracture healing rates and postoperative functional recovery. Moreover, there is a lack of comparative analysis between robot-assisted surgery and traditional surgical approaches.

Purpose

The purpose of this study was to compare the clinical outcomes of patients with femoral neck fractures treated with TiRobot-assisted hollow screw fixation with those of patients with femoral neck fractures treated with traditional surgical approaches.

Methods

This study included 112 patients with femoral neck fracture who were treated from March 2017 to October 2021 with percutaneous hollow screw internal fixation. These included 56 cases in the TiRobot-assisted surgery group and 56 cases in the standard surgery group. After at least 1 year of follow-up, the treatment outcomes of the two groups were compared, including the amount of intraoperative bleeding, the duration of intraoperative fluoroscopy, the number of guide pin positioning adjustments, the length of hospital stay, the accuracy rate of screw placement, the final Harris Hip Score, the fracture healing rate, and the rate of femoral head necrosis. Statistical analysis software was used to process and analyze the result.

Results

The TiRobot-assisted group had a statistically significant improvement over the control group in terms of intraoperative bleeding, the duration of intraoperative fluoroscopy, the number of guide pin positioning adjustments, length of hospital stay, accuracy of screw placement and incidence of femoral head necrosis (P < 0.05). There was no statistically significant difference in time to surgery, final Harris hip score and fracture healing rate (P > 0.05).

Conclusion

This study shows that TiRobot-assisted surgery has the advantages of short hospital stay, high safety, minimally invasive, high success rate of nail placement, and can reduce the amount of intraoperative radiation and the incidence of femoral head necrosis, thus achieving satisfactory clinical outcomes, and is worthy of clinical promotion.
Design, synthesis, in vitro anticancer, molecular docking and SAR studies of new series of pyrrolo[2,3-d]pyrimidine derivatives
Authors: Sroor Farid M. , Tohamy Wael M. , Zoheir Khairy M. A. , Abdelazeem Nagwa M. , Mahrous Karima F. , Ibrahim Nada S.
Published: August 2023

The current study involves the design and synthesis of a newly synthesized pyrrolo[2,3-d]pyrimidine derivatives to contain chlorine atoms in positions 4 and 6 and trichloromethyl group in position 2 using microwave technique as a new and robust approach for preparation of this type of pyrrolo[2,3-d]pyrimidine derivatives. The chemical structure of the synthesized pyrrolo[2,3-d]pyrimidine derivatives 3–19 was well-characterized using spectral and elemental analyses as well as single-crystal X-ray diffraction. All compounds were tested in vitro against seven selected human cancer cell lines, namely, MCF7, A549, HCT116, PC3, HePG2, PACA2 and BJ1 using MTT assay. It was found that compounds 14a, 16b and 18b were the most active toward MCF7 with IC50 (1.7, 5.7, and 3.4 μg/ml, respectively) relative to doxorubicin (Dox.) (26.1 μg/ml). Additionally, compound 17 exerted promising cytotoxic effects against HePG2 and PACA2 with IC50 (8.7 and 6.4 μg/ml, respectively) relative to Dox. (21.6 and 28.3 μg/ml, respectively). The molecular docking study confirmed our ELISA result which showed the promising binding affinities of compounds 14a and 17 against Bcl2 anti-apoptotic protein. At the gene expression level, P53, BAX, DR4 and DR5 were up-regulated, while Bcl2, Il-8, and CDK4 were down-regulated in 14a, 14b and 18b treated MCF7 cells. At the protein level, compound 14b increased the activity of Caspase 8 and BAX (18.263 and 14.25 pg/ml) relative to Dox. (3.99 and 4.92 pg/ml, respectively), while the activity of Bcl2 was greatly decreased in 14a treated MCF7 (2.4 pg/ml) compared with Dox. (14.37 pg/ml). Compounds 14a and 14b caused cell cycle arrest at the G1/S phase in MCF7. Compounds 16b and 18b induced the apoptotic death of MCF7 cells. In addition, the percentage of fragmented DNA was increased significantly in 14a treated MCF7 cells.
Genomic analyses indicate the North American Ap-ha variant of the tick-vectored bacterium Anaplasma phagocytophilum was introduced from Europe
Authors: Aardema Matthew L.
Published: August 2023

Background

Anaplasma phagocytophilum is a tick-vectored, obligately intracellular bacterium that infects a diversity of vertebrate hosts. In North America, the Ap-ha variant of A. phagocytophilum can cause dangerous infections in humans, whereas symptomatic human infections in Europe are rare. Conversely, the European host-generalist ecotype of A. phagocytophilum frequently causes illness in domestic ruminants while no comparable infections have been recorded from North America. Despite these differences in pathogenicity, the Ap-ha variant is closely aligned phylogenetically with the European host-generalist ecotype. Furthermore, North American populations of A. phagocytophilum are less genetically diverse than those in Europe. Taken together, these observations suggest that the North American Ap-ha variant may represent an introduced population of this bacterium.

Methods

Data from publicly available whole genomes of A. phagocytophilum were used to compare phylogeographic patterns and the extent of genetic divergence between the North American Ap-ha variant and the European host-generalist ecotype.

Results

The results confirm that North American Ap-ha samples are phylogenetically nested within the diversity of the European host-generalist ecotype, and that Ap-ha likely radiated within the last 100 years. As expected, the Ap-ha variant also exhibited relatively low genetic diversity levels compared to the European host-generalist ecotype. Finally, North American Ap-ha harbored significantly more derived alleles than the European host-generalist A. phagocytophilum population.

Conclusions

Collectively, these results support the hypothesis that the Ap-ha variant was recently introduced to North America from Europe and underwent a strong genetic bottleneck during this process (i.e. a ‘founder event’). Adaptation to novel vectors may have also played a role in shaping genetic diversity and divergence patterns in these pathogenic bacteria. These findings have implications for future studies aimed at understanding evolutionary patterns and pathogenicity variation within A. phagocytophilum.

Graphical Abstract
Ulam stability of first-order nonlinear impulsive dynamic equations
Authors: Scindia Pallavi , Tikare Sanket , El-Deeb Ahmed A.
Published: August 2023

This paper is devoted to the investigation of Ulam stability of first-order nonlinear impulsive dynamic equations on finite-time scale intervals. Our main objective is to formulate sufficient conditions under which the class of first-order nonlinear impulsive dynamic equations on time scales we consider exhibits Ulam stability. Our methods rely on the extended integral inequality on time scales for piecewise-continuous functions. We provide an example to support the validity of the results obtained.
Positive solutions for a class of fractional differential equations with infinite-point boundary conditions on infinite intervals
Authors: Cui Ziyue , Zhou Zongfu
Published: August 2023

In this paper, the existence of the multiple positive solutions for a class of higher-order fractional differential equations on infinite intervals with infinite-point boundary value conditions is mainly studied. First, we construct the Green function and analyze its properties, and then by using the Leggett–Williams fixed point theorem, some new results on the existence of positive solutions for the boundary value problem are obtained. Finally, we illustrate the application of our conclusion by an example.
High-resolution shallow crustal shear wave velocity structure of Anyuan mining area and its adjacent region in Jiangxi Province, China
Authors: Gong Meng , Lv Jian , Zhang Xingmian , Zheng Yong , Chen Hao , Dong Jun , Zha Xiaohui , Li Zheng , Sheng Shuzhong , Wang Tongli
Published: August 2023

High-resolution seismic image is critically important for mining minerals. In this study, we collected seismic data from a local dense seismic array consisting of 154 stations around the Anyuan mining area and its adjacent region of Pingxiang City, Jiangxi Province in South China, and applied the ambient noise tomography (ANT) method to image the shear wave velocity structure in the study area. Shallow crustal velocities at depths less than 3.3 km were determined by direct inversion of Rayleigh wave group velocity dispersion curves at the period range of 0.5–5.0 s. Overall, the S-wave velocity structure has a tight correlation with surface geological and tectonic features in the study area. The shear wave velocity structure in the shallow crust of the Anyuan Mine and its adjacent areas displayed distinct low-velocity anomalies, which can be attributed to the depression of sedimentary structures and coal mining activities in the Pingxiang-Leping region. The zones surrounding the Anyuan fault (AYF) and Wangkeng fault (WKF) zones exhibited low-velocity anomalies from the ground surface to ~ 3.3 km underground. And the low-velocity anomalies at depths less than 1.2 km could be related to the sedimentary environment of coal mine and the coal mining activities, while the low-velocity anomalies at depths below 1.2 km are caused by the presence of fracture medium, oil and gas in the fault zone. The shear wave velocity changes sharply across the AYF, and the characteristics of the velocity change interface indicate that the AYF is inclined toward the northwest, with its extension reaching depths of approximately 3 km underground.

Graphical Abstract
Relationship between piglets’ survivability and farrowing kinetics in hyper-prolific sows
Authors: Schoos Alexandra , Muro Bruno Bracco Donatelli , Carnevale Rafaella Fernandes , Chantziaras Ilias , Biebaut Evelien , Janssens Geert Paul Jules , Maes Dominiek
Published: August 2023

Background

Prolonged farrowing and more piglets born with low birth weight are undesirable consequences of genetic selection for increased litter size. The objective of the present observational study was to evaluate the relationship between piglets’ survivability and farrowing kinetics in hyperprolific sows. A total of 58 sows of different parities and 1190 piglets were included. The entire farrowing process was monitored and the following parameters were recorded: inter-piglet birth interval, birth order, total born, live born, dead born, and mummified piglets, obstetric intervention, weight at birth and 24h, colostrum yield and intake.

Results

The sows included in this study had on average 20.6 ± 0.6 total piglets born, of which 16.4 ± 0.6 were live born, 3.3 ± 0.4 were stillborn and 0.9 ± 0.2 were mummified piglets. The average farrowing duration and average birth interval were 411.3 ± 31.6 and 20.6 ± 1.7 min, respectively. Farrowing duration was positively associated (p < 0.05) with parity, number of stillborn and mummified piglets. Piglet mortality 24h after birth was negatively affected (p < 0.01) by birth weight and positively affected (p < 0.01) by cumulative birth interval. The last tercile of piglets born (birth order ≥ 17) had the highest (p < 0.01) inter-piglet birth interval (IPBI) (43.4 ± 4.17 min) compared to piglets born in the first (birth order between 2 and 7) (26.5 ± 3.8 min) and second (birth order between 8 and 16) terciles (21.9 ± 3.8 min). Cumulative birth interval, birth weight, occurrence of stillborn piglets and manual intervention were positively associated (p < 0.05) with IPBI. Piglet birth weight was also positively associated (p < 0.01) to individual colostrum intake. Piglets ingesting more colostrum had lower (p < 0.01) mortality from 24h after birth until weaning. Sow’s parity and cumulative birth interval were positively associated with the presence of stillborn piglets (p = 0.02 andp < 0.01, respectively).

Conclusion

Reducing farrowing duration may be crucial to decrease stillbirth rate and neonatal mortality in hyperprolific sows. Moreover, special care must be provided to the lighter piglets within a litter to increase their colostrum intake and minimize piglet’s mortality throughout lactation.
Sebaceous carcinoma of nasal ala: a case report
Authors: Chakravarti Arunabha , Negi Prerna , Singh Parvendra , Sam Sneha Mary , Agarwal Kiran
Published: August 2023

Background

Sebaceous carcinoma is an uncommon non-melanoma skin cancer. Extraocular sites are extremely rare, with only a few cases reported in the medical literature. This article reviews the diagnostic challenges and treatment of a case of sebaceous carcinoma of nasal ala.

Case presentation

A 75-year-old female presented with a slow-growing right nasal alar mass for the last 1.5 years. It was nodular in appearance and covered with crusts and concretions. An incisional biopsy confirmed the diagnosis of sebaceous carcinoma. The patient underwent a wide local excision of the mass followed by nasolabial flap reconstruction.

Conclusions

Sebaceous Carcinoma should be included in the differential diagnosis of an elderly patient with nasal growth to avoid delaying treatment.
Subclinical cardiac dysfunction may impact on fluid and vasopressor administration during early resuscitation of septic shock
Authors: Murgolo Francesco , Mussi Rossella di , Messina Antonio , Pisani Luigi , Dalfino Lidia , Civita Antonio , Stufano Monica , Gianluca Altamura , Staffieri Francesco , Bartolomeo Nicola , Spadaro Savino , Brienza Nicola , Grasso Salvatore
Published: August 2023

Background

According to the Surviving Sepsis Campaign (SSC) fluids and vasopressors are the mainstays of early resuscitation of septic shock while inotropes are indicated in case of tissue hypoperfusion refractory to fluids and vasopressors, suggesting severe cardiac dysfunction. However, septic cardiac disfunction encompasses a large spectrum of severities and may remain “subclinical” during early resuscitation. We hypothesized that “subclinical” cardiac dysfunction may nevertheless influence fluid and vasopressor administration during early resuscitation. We retrospectively reviewed prospectically collected data on fluids and vasoconstrictors administered outside the ICU in patients with septic shock resuscitated according to the SSC guidelines that had reached hemodynamic stability without the use of inotropes. All the patients were submitted to transpulmonary thermodilution (TPTD) hemodynamic monitoring at ICU entry. Subclinical cardiac dysfunction was defined as a TPTD-derived cardiac function index (CFI) ≤ 4.5 min−1.

Results

At ICU admission, subclinical cardiac dysfunction was present in 17/40 patients (42%; CFI 3.6 ± 0.7 min−1 vs 6.6 ± 1.9 min−1; p < 0.01). Compared with patients with normal CFI, these patients had been resuscitate with more fluids (crystalloids 57 ± 10 vs 47 ± 9 ml/kg PBW; p < 0.01) and vasopressors (norepinephrine 0.65 ± 0.25 vs 0.43 ± 0.29 mcg/kg/min; p < 0.05). At ICU admission these patients had lower cardiac index (2.2 ± 0.6 vs 3.6 ± 0.9 L/min/m2, p < 0.01) and higher systemic vascular resistances (2721 ± 860 vs 1532 ± 480 dyn*s*cm−5/m2, p < 0.01).

Conclusions

In patients with septic shock resuscitated according to the SSC, we found that subclinical cardiac dysfunction may influence the approach to fluids and vasopressor administration during early resuscitation. Our data support the implementation of early, bedside assessment of cardiac function during early resuscitation of septic shock.
Room Temperature Anionic Episulfide Resin Adhesive UV-curable by a Thiol Initiator and Photobase Generator
Authors: Aoki Daisuke , Gu Chen , Suzuki Mayu , Kawamura Yoshinori , Arimitsu Koji
Published: August 2023

To address the challenges associated with room temperature curing of UV-curable epoxy adhesives, we present room temperature anionic UV-curable episulfide adhesives. The episulfide adhesives incorporate a thiol initiator and photobase generators (PBGs), composed of xanthone and phosphazene superbases. Lap shear adhesion tests demonstrated that the thiol initiator significantly enhances the lap shear strength of episulfide resin adhesives, reaching a maximum of 13 MPa. Moreover, FT-IR studies confirmed that thiol initiators accelerate the curing reaction of episulfides at room temperature.
Pensão militar - Companheira
Authors: Affonso Sebastião B.
Published: August 2023

Tribunal de Contas da União
Imposto de renda - Empreiteiros de obras - Sociedades civis
Authors: Campos Vicente de Paulo
Published: August 2023

Ministério da Fazenda
Modos e práticas legais na execução dos serviços públicos
Authors: Franco Sobrinho Manuel de Oliveira
Published: August 2023

Modos de gestão. A lei como "egra e medida. Administração na ordem positiva. Ao Estado cabe a escolha da pessoa jurídica. Formas adequadas e particiPação. O instrumento adotado no processo criador. As estruturas orgânicas. Missão funcional e personalidade jurídica. A prestação indireta de serviços. Regras jurídicas e capacidade. As pessoas administrativas. Interesse público e negócio jurídico. O fato e a lei. Faculdades opcionais e não-discricionariedade. Personalidade e capacidade. Distinção na oPção da forma legal. Expansão dos instrumentos operacionais. As figuras jurídicas de associação internacional. A escolha da forma jurídica no Brasil. Conclusão.
Funcionário público - Restituição de importâncias recebidas por força de decisão judicial - Mandado de segurança
Authors: Albuquerque Xavier de
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Agente fiscal - Remuneração - Regulamento
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Advocacia
Authors: Baleeiro Aliomar
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Contagem de tempo de serviço - Gratificação paga pelo verba 3
Authors: Rocha Eloy da
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Abandono de emprego - Processo administrativo - Demissão
Authors: Gallotti Luiz
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Gratificação de representação - Agregação
Authors: Ramos Romeo de Almeida
Published: August 2023

Presidência da República
Funcionário público - Professor - Vencimento
Authors: Silva Glauco Lessa de Abreu e
Published: August 2023

Departamento Administrativo do Pessoal Civil
Funcionário público - Licença para acompanhar cônjuge
Authors: Santos Waldyr dos
Published: August 2023

Departamento Administrativo do Pessoal Civil
Funcionário público - Mandato eletivo
Authors: Silva Glauco Lessa de Abreu e
Published: August 2023

Departamento Administrativo do Pessoal Civil
Funcionário público - Contagem de tempo de serviço
Authors: Santos Waldyr dos
Published: August 2023

Departamento Administrativo do Pessoal Civil
Professor adjunto - Provimento
Authors: Ramos Romeo de Almeida
Published: August 2023

Presidência da República
Professor - Estabilidade
Authors: Ramos Romeo de Almeida
Published: August 2023

Presidência da República
Concessão de serviço público - Ativo imobilizado - Correção monetária
Authors: Ramos Romeo de Almeida
Published: August 2023

Presidência da República
Aforamento - Laudêmio - Opção - Prazo
Authors: Ramos Romeo de Almeida
Published: August 2023

Presidência da República
Imposto de renda - Incentivos fiscais - Certificado de compra de ações
Authors: Campos Vicente de Paulo
Published: August 2023

Ministério da Fazenda
Imunidade tributária - Isenção tributária - Foro - Laudêmio e taxa de ocupação - Banco Central do Brasil
Authors: Ramos Romeo de Almeida
Published: August 2023

Presidência da República
Poder regulamentar - Empreitada de obra pública - Reajustamento de preços - Correção monetária
Authors: Wald Arnaldo
Published: August 2023

- Não pode a regulamentação de uma lei, ou de um Decreto-lei, imPlicar em limitação a sua área de incidência.- O princíPio firmado pelo Decreto-lei n9 185, de 1967, foi oda correção monetária de acordo com a inflação, sem qualquer limitação ou teto, a fim de garantir a manutenção do poder aquisitivo das quantias devidas ao empreiteiro, resguardando-se, assim, o equilíbrio financeiro, que é essencial nos contratos do direito público.- Interpretação do Decreto-lei n9 185, de 1967.- Ilegalidade dos Decretos n.oa 60.407 e 60.706, de 1967.
Teoria e prática do desvio de poder
Authors: Tácito Caio
Published: August 2023

1. Conceito de desvio de poder. 2. Desvio de poder na doutrina brasileira. 3. Desvio de poder na jurisprudência brasileira. 4. Desvio de poder nas desapropriações. 5. Conclusão.
Imposto de importação - Redução de alíquota - Soda cáustica - Tributação uniforme
Authors: Gallotti Luiz
Published: August 2023

Supremo Tribunal Federal
Imposto de importação - Redução - Isenção
Authors: Trigueiro Oswaldo
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Concurso - Anulação - Processo administrativo
Authors: Albuquerque Xavier de
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Estabilidade - Efetivação
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Aposentadoria - Revisão de proventos - Restituição
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Demissão - Controle judicial
Authors: Monteiro Barros
Published: August 2023

Supremo Tribunal Federal
Serventuário da justiça - Aposentadoria - Cálculo de proventos
Authors: Trigueiro Oswaldo
Published: August 2023

Supremo Tribunal Federal
Acumulação remunerada - Correlação de matérias - Aposentadoria
Authors: Flôres Thompson
Published: August 2023

Supremo Tribunal Federal
Acumulação remunerada - Cargo técnico - Decisões administrativas
Authors: Alckmin Rodrigues
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Desistência
Authors: Carvalho Costa
Published: August 2023

Tribunal de Alçada de São Paulo
Bens públicos - Usucapião - Prescrição
Authors: Baleeiro Aliomar
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Exercício em Brasília - Indenização - Ajuda de custo
Authors: Duarte Clenício da Silva
Published: August 2023

Presidência da República
Funcionário público - Professor - Estabilidade
Authors: Cotrim Neto Alberto Bittencourt , Pinto Celso Muniz Guedes , Barros Adalmyr Brandão Pinheiro de
Published: August 2023

- Interpretação do art. 177, § 29 da Constituição de 1967.
Taxa de expediente - Imposto sobre serviços - Fato gerador - Poder de polícia
Authors: Monteiro Barros
Published: August 2023

Supremo Tribunal Federal
Taxa de fiscalização - Mercadorias remetidas para o exterior - Inconstitucionalidade - Representação
Authors: Baleeiro Aliomar
Published: August 2023

Supremo Tribunal Federal
Constituição do Estado - Declaração de inconstitucionalidade - Representação
Authors: Monteiro Barros
Published: August 2023

Supremo Tribunal Federal
Sentença de primeira instância reconhecendo o direito adquirido dos serventuários da Justiça da Guanabara
Authors: Reichartdt Américo A.G. Canabarro
Published: August 2023

.
Tomada de contas - Ordenador de defesa - Almoxarife
Authors: Affonso Sebastião Baptista
Published: August 2023

Tribunal de Contas da União
Funcionário público - Auxílio familiar
Authors: Mayer Luiz Rafael
Published: August 2023

Presidência da República
Funcionário público - Abandono de cargo
Authors: Siqueira Darcy Duarte de
Published: August 2023

Presidência da República
Imposto de renda - Cessão de direitos sobre propriedades imobiliárias
Authors: Desconhecido Autor
Published: August 2023

Ministério da Fazenda
Taxa de conservação de estradas - Taxa rodoviária única - Competência tributária cumulativa
Authors: Queiroz Cid Heráclito de
Published: August 2023

Ministério da Fazenda
Fazenda pública - Processo de inventário
Authors: Costa Carlos Jorge Sampaio
Published: August 2023

Ministério da Fazenda
As Caixas Econômicas Estaduais e A Reforma Administrativa Federal
Authors: Carvalho Luiz Airton de
Published: August 2023

1. A empresa pública Caixa Econômica Federal. 2. Atuação daCEF no meio financeiro do país. 3. As caixas econômicas estaduais. 4. As caixas econômicas estaduais e a reforma administrativa federal. 5. Atuação das caixas econômicas estaduais no meio financeiro.
Imposto de renda - Remessa de juros para o exterior
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Estabilidade - Efetividade
Authors: Albuquerque Xavier de
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Agregação
Authors: Baleeiro Aliomar
Published: August 2023

Supremo Tribunal Federal
Fundo de participação de municípios - Banco do Brasil - Correção monetária
Authors: Branco Francisco de Salles Mourão
Published: August 2023

Tribunal de Contas da União
Funcionário público - Classificação de cargos - Serviços públicos essenciais - Provimento
Authors: Duarte Clenício da Silva
Published: August 2023

Departamento Administrativo do Pessoal Civil
Débito fiscal - Lançamento - Multa - Ação anulatória
Authors: Queiroz Cid Heráclito de
Published: August 2023

Ministério da Fazenda
Juízo arbitral - Limites entre estados - Eficácia do laudo
Authors: Mayer Luiz Rafael
Published: August 2023

Presidência da República
Concorrência pública - Licitação - Limites de discricionariedade no julgamento das proprostas
Authors: Mello Celso Antonio Bandeira de
Published: August 2023

A teoria do desvio de poder e dos motivos determinantes éque tem servido eficazmente para o reconhecimento dos limites da liberdade do administrador.- A discricionariedade é a margem de liberdade conferidapela lei ao administrador para decidir segundo um critério próprio, baseado em conveniência e oportunidade, a fim de compor no caso específico a concreta vontade legal.
Problemas atuais da desapropriação
Authors: Tácito Caio
Published: August 2023

Evolução histórica. Desapropriação e inflação. Desapropriação de ações. Desapropriação e desvio de poder. Desapropriação e urbanismo. Desapropriação e reforma agrária. Outras situações relevantes. Conclusão.
Conceituação do direito administrativo
Authors: Oliveira Fernando Andrade de
Published: August 2023

Divergências doutrinárias sobre o tema. A composição é o objeto do direito administrativo. Administração Pública e Governo. A distinção entre atos políticos e atos administrativos. A Constituição como fonte de atos políticos. (Continua no pr6ximo volume).
Imposto de renda - Aumento de preços - Ordem de serviço
Authors: Baleeiro Aliomar
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Regime de dedicação exclusiva - Relação estatutária
Authors: Monteiro Barros
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Procurador - Equiparação de vencimentos
Authors: Trigueiro Oswaldo
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Restituição de vantagens
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Promotor - Serventuário de justiça - Vinculação de vencimentos
Authors: Albuquerque Xavier de
Published: August 2023

Supremo Tribunal Federal
Tribunal de Contas - Prerrogativas de seus membros - Representação
Authors: Albuquerque Xavier de
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Execução - Honorários de advogado
Authors: Gallotti Luiz
Published: August 2023

Supremo Tribunal Federal
Prestação de contas - Departamento Nacional de Estradas de Rodagem
Authors: Affonso Sebastião Baptista
Published: August 2023

Tribunal de Contas da União
Tribunal de contas - Prazo
Authors: Branco Francisco de Salles Mourão
Published: August 2023

Tribunal de Contas da União
Patrimônio Histórico e Artístico Nacional - Tombamento - Notificação do Proprietário - Registro - Nulidade
Authors: Silva Carlos Medeiros
Published: August 2023

- A competência conferida ao serviço federal para o tombamentode bens, não exclui a de serviços congêneres instituídos parao mesmo fim, pelos estados e municípios.- O tombamento oneroso exige a desapropriação com o pagamentoda justa indenização em dinheiro.- Atos arbitrários e, portanto, nulos, não podem prosperar.
Imposto de renda - Contribuição ao PIN, PROTERRA e PIS
Authors: Martins Yves Gandra da Silva
Published: August 2023

- As contribuições devidas ao PIN, Proterra e PIS são despesasoperacionais, dedutíveis do imposto de renda.
Imposto sobre circulação de mercadorias - Cumulatividade
Authors: Falcão Djaci
Published: August 2023

Supremo Tribunal Federal
Imposto sobre serviços - Associação civil
Authors: Trigueiro Oswaldo
Published: August 2023

Supremo Tribunal Federal
Imposto - Pagamento - Descaminho - Extinção da punibilidade
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Taxa Rodoviária Única - Serviço de trânsito - Linha urbana de ônibus
Authors: Barbuto Marzagão
Published: August 2023

Tribunal de Alçada de São Paulo
Funcionário público - Concurso - Nomeação
Authors: Leite Costa
Published: August 2023

Tribunal de Justiça de São Paulo
Funcionário público - Gratificação de tempo integral - Direito adquirido
Authors: Gallotti Luiz Octavio
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Prefeito - Vantagens - Opção
Authors: Granato Rafael
Published: August 2023

Tribunal de Justiça de São Paulo
Desapropriação - Depósito complementar - Honorários de advogado
Authors: Gallotti Luiz
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Acordo - Homologação
Authors: Almada Ney
Published: August 2023

Tribunal de Alçada de São Paulo
Banco Nacional de Desenvolvimento Econômico - Fundação de Assistência e Previdência Social
Authors: Affonso Sebastião Baptista
Published: August 2023

Tribunal de Contas
Desfalque - Confisco de bens - Ato institucional
Authors: Affonso Sebastião Baptista
Published: August 2023

Tribunal de Contas
Imposto - Restituição - Correção monetária - Lei injusta
Authors: Gallotti Luiz
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Contagem de tempo de serviço
Authors: Abreu Leitão de
Published: August 2023

Supremo Tribunal Federal
Procurador - Gratificação de representação - Aposentadoria
Authors: Zaban Aldo
Published: August 2023

- Não se aplica aos funcionários do Ministério Público daUnião, a Resolução da Cmnara dos Deputados sobre a inclusão da gratificação de representação nos proventos da inatividade.
Imposto de renda - Créditos de liquidação duvidosa - Alienação fiduciária
Authors: Kahan Iraci
Published: August 2023

Ministério da Fazenda
Dívida fiscal - Pagamento parcelado
Authors: Queiroz Cid Heráclito de
Published: August 2023

Ministério da Fazenda
Funcionário público - Cargo em comissão - Função gratificada
Authors: Siqueira Darcy Duarte de
Published: August 2023

Departamento Administrativo do Serviço Público
Funcionário público - Classificação de cargo
Authors: Siqueira Darcy Duarte de
Published: August 2023

Departamento Administrativo do Serviço Público
Funcionário público - Tesoureiro-auxiliar - Aproveitamento
Authors: Siqueira Darcy Duarte de
Published: August 2023

Departamento Administrativo do Serviço Público
Professor - Enquadramento
Authors: Siqueira Darcy Duarte de
Published: August 2023

Departamento Administrativo do Serviço Público
Controle integrado do ato administrativo
Authors: Jappur José
Published: August 2023

Estado e direito. As regras do controle no tempo e na atualidade. Os princípios de legalidade e de legitimidade. Moralidade administrativa.A moral e o direito. A forma e a substância. O exame do mérito. Preconceito do passado e novas linhas do presente. Moralidadecomo legitimidade de fins e motivos determinantes. O controle da "livre discrição". Auditoria das contas como instrumento do controle integrado. Tomada de contas. Seu conteúdo múltiplo. Missão moderna dos Tribunais de Contas.
Taxa de despacho aduaneiro - Repetição
Authors: Alckmin Rodrigues
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Nomeação - Nulidade
Authors: Trigueiro Oswaldo
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Pena disciplinar - Prescrição
Authors: Gallotti Luiz
Published: August 2023

Supremo Tribunal Federal
Responsabilidade civil do estado - Empréstimo de veículo
Authors: Pinto Bilac
Published: August 2023

Supremo Tribunal Federal
Ação popular - Desapropriação - Revogação do ato impugnado - Honorários de advogado
Authors: Santos Manoel Carlos dos
Published: August 2023

Tribunal de Alçada de São Paulo
Tomada de contas - Fundação Instituto Oswaldo Cruz - Licitação
Authors: Affonso Sebastião Baptista
Published: August 2023

Tribunal de Contas da União
Imposto de importação - Fato gerador
Authors: Falcone Hermano Américo
Published: August 2023

Ministério da Fazenda
Pensão especial - Viúvas de ex-presidentes da república - Acumulação
Authors: Mayer Luiz Rafael
Published: August 2023

Presidência da República