bluuebunny/crossref_metadata_2025 huggingface dataset:
CORRELATION OF MORBIDITY WITH SMOKING STATUS AND POSBINDU PTM TO PREPARE AGING SOCIETY HEALTH MANIFESTATION IN INDONESIA
Authors: Nastiti Rizma Dwi , Hargono Arief , Artanti Kurnia Dwi , Martini Santi , Li Chung-Yi , Triyaniarta Adinda Rahma
Published: September 2024

Aging increases vulnerability to diseases, necessitating comprehensive strategies promoting healthy lifestyles. Posbindu PTM (Integrated Guidance Post for NCDs) is Indonesia's community-based program which was aimed to mitigate the impact of NCDs through monitoring risk factors and empowering individuals for early intervention and lifestyle’s changes. This study examined the correlations between smoking status, and implementation of Posbindu PTM among Indonesia's elderly population with morbidity rates. Data from 34 provinces were analyzed using Spearman's correlation test (α=5%) to examine relationships between morbidity rates (dependent variable) from the 2022 Elderly Population Statistics data, smoking status (active smokers, ex-smokers, non-smokers), and the percentage of Posbindu PTM implementation (independent variables) from the data of the 2021 Indonesia Health Profile. Active smokers (p=0.007, r=0.455) and ex-smokers (p=0.003, r=0.497) showed positive correlations with morbidity, while non-smokers (p=0.002, r=-0.506) exhibited a negative correlation. Posbindu PTM implementation (66,4% average in 2021) was not significantly correlated with morbidity (p=0.367). High smoking rates among Indonesia's elderly affect morbidity levels. Posbindu PTM, as an early detection and health promotion program, has not been well-implemented nationwide. Efforts and government commitment to prioritize health promotion and prevention at the grassroots level are essential for achieving a prosperous and effective aging society.
SPATIAL AUTOCORRELATION ANALYSIS OF PULMONARY TUBERCULOSIS CASES IN CENTRAL JAVA PROVINCE
Authors: Puspita Septiani
Published: September 2024

Tuberculosis is a disease that is easily transmitted and causes worry across the world. Central Java Province became one of the regions contributing the most tuberculosis cases in Indonesia in 2022, which amounted to 22,249 cases. This study aims to examine the local and global spatial autocorrelation of pulmonary tuberculosis cases in the Central Java Province in 2022. This research is an analytic observational research with an ecological study design. The unit of analysis used was 35 districts/cities. This study used secondary data from the Health Profile of Central Java Province in 2022. Data analysis used Moran's Index and Local Indicators of Spatial Associaton (LISA) methods with queen contiguity weighting in Geoda software.  The results showed that Moran's index value of the global autocorrelation test on the number of pulmonary tuberculosis cases was 0.505. The results of the bivariate LISA test obtained the p value of tuberculosis cases with population, population density, and number of health facilities of 0.002, 0.449, and 0.007, respectively, with the Moran index value of 0.3111, 0.0075, and 0.2384 respectively. There are 9 spatially significant areas between population, population density, and number of health facilities with tuberculosis cases. This study concludes that there is a positive spatial autocorrelation (clustering pattern) of pulmonary tuberculosis cases in Central Java Province in 2022. In addition, there is positive spatial autocorrelation between population and number of health facilities with TB cases (clustering pattern) and there is no spatial autocorrelation between population density and TB cases.
Bursa Bölgesinden Toplanan Ekşi Mayalardan Elde Edilen Enterokok İzolatlarının Gıda Güvenliği ve Fonksiyonel Karakterizasyonu
Authors: Sokmen Ozen , Düven Gamze , Ay Mustafa , Özmen Toğay Sine
Published: September 2024

Bu çalışmada Bursa bölgesinden toplanan 30 adet ekşi mayadan izole edilen enterokokların gıda güvenliği ve fonksiyonel karakteristiğinin belirlemesi amacıyla örneklerden elde edilen izolatların antibiyotik direnç ve antimikrobiyal aktivitesinin tespiti, virülens gen ve antibiyotik direnç genlerinin aranması, düşük pH ve safraya karşı direnç özelliklerinin belirlenmesi çalışmaları yapılmıştır. Çalışmada, ekşi maya örneklerinden toplam 178 adet laktik asit bakteri suşu izole edilmiş ve bunların 7 tanesinin enterekok cinsine ait olduğu tespit edimiştir. Bu suşların test bakterilerine (Salmonella typhimurium ATCC 14028, Escherichia coli ATCC 25922, Streptococcus mutans, Streptococcus aureus 6538, Enterococcus faecalis ATCC 29212, Enterococcus faecium M74, Streptococcus pyogenes ATCC 6538, Listeria innocua ATCC 33090, Listeria monocytogenes ATCC 19111 ) karşı antimikrobiyal aktiviteye sahip olduğu tespit edilmiş ve virülans (agg, gelE, cylM, cylB, cylA) ve antibiyotik direnç genlerini (vanA, vanB, tetM, ermB, aac(6’)-aph(2’’)-la) taşıma açısından güvenli bulunmuştur. İzolatların düşük pH ve safra direnç özelliklerinin incelendiğinde, pH 4’de 3. saatin sonunda canlılıklarını koruduklarını fakat pH 2 ve pH 3’ de 3. saatin sonunda enterokokların canlı kalamadığı tespit edilmiştir. %0.5 (w/v) safra derişimine direnç özelliklerini gösteren sayım sonuçları incelendiğinde 24. saatin sonunda 6.2-7.4 log-kob/g düzeylerinde canlı kaldıkları belirlenmiştir.
Analysis of Land Acquisition for Yogyakarta International Airport with a Socio-Judicial Approach from an Islamic Law Perspective
Authors: Al-Ghazali Muh. Nurkhalid , Yusdani Yusdani
Published: September 2024

The use of land belonging to other people for the public interest is still justified in Islam, of course in a fair and voluntary manner. The land acquisition area for the construction of Yogyakarta International Airport is 637 hectares with 60% of the production land being privately owned by the people and the remainder being Pakualaman Ground. This triggered rejection and even disappointment from residents due to the lack of realization of deliberative agreements. The author examines problems related to the reality of land acquisition for Yogyakarta International Airport using a socio-juridical approach along with the study from an Islamic legal perspective. This qualitative research uses a socio-juridical approach method. The authors combined all primary data in the form of interviews and analyzed it with legal documents related to research material from both legislation and Islamic law. The researcher concluded that land acquisition for the development of Yogyakarta International Airport using a socio-juridical approach has been carried out in stages that uphold the rights of affected residents by considering all possible impacts of land acquisition that will be felt by affected residents, where these stages are appropriate. with statutory law and Islamic law.
The Relationship Between Authoritarian Parenting and Psychological Well-Being in Adolescents
Authors: Fajri Diva Widyawati Anggraeni , Kusumaningrum Fitri Ayu
Published: September 2024

Psychological well-being is a condition where an individual can accept themselves well, acknowledge their past experiences, maintain good relationships with others, and have clear and meaningful goals. This study aims to gather information and determine whether there is a relationship between authoritarian parenting by parents (both mother and father) and the psychological well-being of adolescents. The study involved 200 adolescents aged 13-19 years and employed a quantitative correlational research design. The measurement tools used in this study included the Psychological Well-Being Scale, adapted and modified by Diener, Derrick, Robert, et al. (2009), and the Parental Authority Questionnaire, adapted by Buri (Riberio, 2009). The results of this study indicate a significant negative relationship between authoritarian parenting by both mothers and fathers and the psychological well-being of adolescents. For mothers, the authoritarian parenting style showed a correlation coefficient (r) of -0.284 with a significance value (p) of 0.000 (p < 0.05). For fathers, the authoritarian parenting style showed a correlation coefficient (r) of -0.220 with a significance value (p) of 0.001 (p < 0.05). Based on these results, it can be concluded that the research hypothesis is accepted. Further discussion includes intercorrelation analysis of different aspects, difference tests, and demographic correlation tests (gender, respondents' educational level, and parents' educational level).
Factors Affecting The Number Of Domestic Flights In Indonesia During Covid-19 Pandemic Using SARIMAX Method
Authors: Zeinawaqi Zahrah , Dzikrullah Abdullah Ahmad
Published: September 2024

Indonesia, which consists of thousands of large and small islands, relies heavily on-air transportation to support mobility between regions. As many as 80% of Indonesia's total air transportation passengers are domestic flight passengers. This shows how vital domestic flights are in Indonesia's air transportation system. However, in 2020, the COVID-19 pandemic had an impact that resulted in a decrease in the number of domestic flights in Indonesia. Therefore, an analysis is needed to determine the factors that affect the number of domestic flights in Indonesia. This study uses the SARIMAX method, a time series regression with the addition of seasonal factors and other variables or exogenous factors that significantly affect the model to improve the model's accuracy. Several exogenous variables are considered, including the number of operating civil aviation airports, positive daily cases of COVID-19, calendar effects during Eid al-Fitr and New Year's Day, and social restriction policies. The results showed that the number of operating airports one week before Eid al-Fitr, one week during Eid al-Fitr, one week before New Year, and Emergency PPKM significantly influenced the number of domestic flights. These variables offer pivotal insights into the influence of external factors on domestic flight patterns, exerting significant impacts on passenger travel behavior and subsequently influencing domestic flight volume. The integration of these variables in the SARIMAX model allows for a comprehensive analysis of the complex dynamics influencing domestic air travel in Indonesia. The best SARIMAX model obtained is SARIMAX (1,1,1)(4,1,1)7 with a MAPE value of 5.35% and a coefficient of determination is 97%.
Short-Term Complications of Arthroscopic Bristow or Latarjet Procedure with Screw Versus Suture-Button Fixation
Authors: Shao Zhenxing , Jiang Yanfang , Song Qingfa , Wang Hangle , Luo Hao , Cheng Xu , Cui Guoqing
Published: September 2024

Background:

This study aimed to investigate the short-term complications (minimum 1-year follow-up) after either an arthroscopic Bristow or Latarjet procedure for anterior shoulder instability utilizing screw or suture-button fixation.

Methods:

Patients undergoing arthroscopic Bristow or Latarjet procedures between November 2016 and April 2021 were enrolled. Data were collected at baseline, 3 months, 6 months, and every year after surgery. Risks of postoperative complications and unplanned reoperations were assessed. A multivariable regression model was used to identify risk factors for complications and to determine the association of complications with patient-reported outcomes.

Results:

A total of 412 patients (425 shoulders) undergoing arthroscopic Bristow or Latarjet procedures performed by a single surgeon between November 2016 and April 2021 were reviewed. Two hundred and ninety-nine patients (308 shoulders, 76.2% of 404 eligible) with a mean follow-up of 22.3 ± 4.2 months were included for analysis. Two hundred and sixty-nine shoulders (87.3%) underwent a Bristow procedure (165 with screw and 104 with suture-button fixation), while 39 (12.7%) underwent a Latarjet procedure (18 with screw and 21 with suture-button fixation). Eighty-two patients (83 shoulders) reported a total of 85 complications within 2 years after surgery, with an overall complication rate of 26.9%. The rates of recurrent dislocation or subluxation and infection were 1.9% and 0.6%, respectively, while a total of 4 (1.3%) of the shoulders had unplanned reoperations. The most common complications were graft-related (11.7%), followed by complications involving neurologic symptoms (10.7%). The overall, graft, and neurologic complication rates following Bristow or Latarjet procedures were 27.1% versus 25.6%, 12.3% versus 7.7%, and 10.0% versus 15.4%, respectively. Compared with the Bristow technique with screw fixation, Bristow with suture-button fixation yielded a lower risk of any complications (odds ratio [OR], 0.55; p = 0.04). Paying with rural insurance and poor sleep quality prior to surgery were associated with increased risk of any complications.

Conclusions:

Compared with arthroscopic Bristow procedures with screw fixation, Bristow procedures with suture-button fixation resulted in a lower overall complication risk. Both patient demographic and implant-specific factors were associated with the development of a complication.

Level of Evidence:

Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Sagittal Fragment Rotation and Ogden Type-I Classification Are Hallmarks of Combined Tibial Tubercle Fracture and Patellar Tendon Injury
Authors: Schultz Rebecca J. , Amaral Jason Z. , Parham Matthew J. , Kitziger Raymond L. , Lee Tiffany M. , McKay Scott D. , Touban Basel M.
Published: September 2024

Background:

Tibial tubercle fractures (TTFs) are uncommon injuries, comprising <3% of all proximal tibial fractures. These fractures occasionally occur in conjunction with a patellar tendon injury (PTI). We aimed to identify risk factors associated with combined TTF and PTI.

Methods:

A retrospective review was performed of patients presenting to a single, tertiary children’s hospital with TTF between 2012 and 2023. Demographic data, operative details, radiographs, and injury patterns were analyzed. Radiographs were assessed for the epiphyseal union stage (EUS), Ogden classification, and fracture patterns. Multiple logistic regression models were used to assess the impact of body mass index, comminution, fracture fragment rotation, EUS, bilateral injury, and Ogden classification on injury type.

Results:

We identified 262 fractures in 252 patients (mean age, 13.9 ± 1.31 years). Of the patients, 6% were female and 48% were Black. Of the 262 fractures, 228 (87%) were isolated TTFs and 34 (13%) were TTFs with PTI. Multivariable analysis demonstrated fragment rotation on lateral radiographs (p < 0.0001) and Ogden Type-I classification (p < 0.0001) to be the most predictive risk factors for a combined injury. Rotation was associated with a substantial increase in the odds of a combined injury, with an odds ratio of 22.1 (95% confidence interval [CI], 6.1 to 80.1). Ogden Type-I fracture was another significant risk factor, with an odds ratio of 10.2 (95% CI, 3.4 to 30.4).

Conclusions:

The Ogden classification and fragment rotation are the most useful features for distinguishing between isolated TTF and combined TTF with PTI. This is the first study to identify risk factors for TTF combined with PTI. Surgeons may use this information to aid in preoperative planning.

Level of Evidence:

Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Challenging Stories: Exploring the Intersections between Health and the Humanities
Authors: V. Jones Kimberly , May Sanchez Gianna , Rashidbeigi Samin , Chen Chuan Hao (Alex) , Espinosa Martha L. , Flood Macey , Beck Emily , Zegarra Chiappori Magdalena , Reznick Jeffrey S. , Vitale IV Frank
Published: September 2024

Challenging Stories explores experiences of demanding health conditions and attitudes in response to them, across historical and contemporary contexts. This collection of original scholarship brings an interdisciplinary perspective to topics such as maternal health, care for aging adults, births by midwives, family planning, infectious disease outbreaks, biosafety health protocols, blood transfusions, and plant-based health practices. The case studies explored in each chapter contribute to a deeper and richer understanding of how challenging stories are embedded in an appreciation of community and individual health.  With contributions by Emily Beck, Chuan Hao (Alex) Chen, Martha L. Espinosa, E. Thomas Ewing, Macey Flood, Priyanka Ganguly, Kimberly V. Jones, Gianna May Sanchez, Samin Rashidbeigi, Jeffrey S. Reznick, Frank Vitale IV, and Magdalena Zegarra Chiappori.
Importance of Leukocyte count, Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Prognosis of Pesticide Poisoning
Authors:   Postgraduate,Department of Pathology, Shri B.M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura 586103, Karnataka, India., Chourishi Shubham , S. Patil Vijayalaxmi ,   Associate Professor,Department of Pathology, Shri B.M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura 586103, Karnataka, India.
Published: September 2024

context: Pesticides are chemical compounds used for crop protection and poisoning with them is a very common occurrence in farmers. In an emergency setting, the identification of quick and powerful prognostic markers can be of high significance in the management of these patients. aIMs: To assess the severity of Pesticide Poisoning by assessing the leukocyte count, neutrophil count, neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) and its comparison with levels of Plasma Cholinesterase (PChE) as an aid to clinical diagnosis, for early treatment of the patients. settIngs and desIgn: Hospital based Cross-sectional study. Study period 1st November 2018 - 30th May 2020 Methods and MaterIal: Study was done on 148 confirmed cases of pesticide poisoning over a period of 1.5 years. Blood samples were collected in EDTA and plain vacutainers within 24 hours of admission and the values of total leukocyte Count (TLC), neutrophil count, NLR, PLR and PChE were measured and compared. The severity of poisoning was assessed according to Peradeniya Organophosphorus (POP) scale. statIstIcal analysIs used: Mean ± SD, Chi square test for association, Comparison of mean using ANOVA test for comparison between and among groups, Sensitivity and specificity analysis. results: 89.86% and 10.14% of cases were due to poisoning by Organophosphorus compounds and carbamate respectively. The severely poisoned patients according to POP scale had more leukocyte count, neutrophil count, NLR and PLR; and less plasma cholinesterase level as compared to the patients with mild and moderate poisoning. conclusIons: Total Leukocyte count,neutrophil count, NLR and PLR are simple and easy to use parameters for estimating the severity of pesticide poisoning and assessing its prognosis. In resource limited setups, along with the clinical history, these basic CBC parameters can be useful and patient’s immediate treatment can be started as early as possible.
Estimating Sexual Dimorphism using Anthropometric measurements of Permanent Dentition
Authors:   Final Year MBBS, Department of Forensic Medicine & Toxicology, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, Jamshedpur 831017, Jharkhand, India., Kusumkant Dhote Kashmira , Guria Jyotish ,   Assistant Professor, Department of Forensic Medicine & Toxicology, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, Jamshedpur 831017, Jharkhand, India., Mishra Ashim ,   Professor, Department of Forensic Medicine & Toxicology, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, Jamshedpur 831017, Jharkhand, India.
Published: September 2024

context: The ability to determine the sex of an unknown person is extremely useful because it narrows the search to nearly half of the population. Teeth are excellent choice for identification since they are resistant to putrefaction and are well protected anatomically. aIMs: The study is aimed at presence of sexual dimorphism in different tooth measurements in the lower jaw. settIngs and desIgn: Cross sectional study Methods and MaterIal: The study was conducted on 51 male and 54 female participants. Exclusion criteria for the subjects were: Dental caries, Crowded or excessive spacing in the anterior teeth, Orthodontic treatment, Occlusal abnormalities, Any trauma to lower jaw. Measurements were taken clinically using geometric divider and digital callipers. Odontometric dimensions included in the study taken from the lower jaw only are: Mesiodistal width (MD) and Buccolingual width (BL) for canine, central incisor and first molar (both left and right) and inter canine width (ICW). statIstIcal analysIs used: Jamovi Software version 2.3.24 was used for statistical analysis. Independent sample t and Binomial logistic regression was applied to see the accuracy of predictive measures for different dimensions in identifying sex of an individual. results: Mesiodistal and buccolingual dimensions of canines, central incisor and first molar in the lower jaw differ significantly in males and females. Mesiodistal dimensions are more accurate in identifying the sexes. Mandibular canines are more sexually dimorphic compared to mandibular central incisors and first molars. conclusIons: The study findings indicate that the Mandibular dental measurements and canine indices can be used as supportive adjunct rather than the sole criteria for sex determination in forensic investigations.
Detection of Gunshot Residue on Glass Fired using Airguns and Insas LMG 5.56mm
Authors:   Assistant Professor, Department of Forensic Science,JAIN (Deemed to be University), Bangalore 560027, Karnataka, India., Mane Manashree , Rajiv Asha ,   Professor, Department of Physics, JAIN (Deemed to be University), Bangalore 560027, Karnataka, India.
Published: September 2024

Locating and retrieving gunshot residue from the scene of the crimeis important for the investigation of shooting-related crime incidents. The presence of gunshot residue on the glass that can be hit as anintermediate target is occasional but not collected commonly because of its nature and the amount found on the glass. They may be found in crimes such as shooting where the target involves windowpanes or windshields among many other shooting related incidents. It is indicative that gunshot residues provide an exemplary source of partially burnt, completely burnt, and unburnt residues of primers and propellants that can help establish the manufacturer’s details. Gunshot residues are deposited on the hands, face, and clothing of the shooter and are commonly found on the entry hole of the targets. These residues can be recovered from the surface of intermediate targets through which the bullet travels. Detection of gunshot residue from these intermediate targets can be useful for forensic investigation. They can be promising in absence of other pieces of evidence such as cartridge cases, bullets, or firearms. The current study was performed to explore the detection of gunshot residue on glasses fired at 25 metres range. Lead, barium, and antimony were successfully detected on all samples fired at 25 metres range. The analysis provided consistent evidence that gunshot residue detected can be helpful to obtain reliable data for forensic investigation. The statistical analysis of the data revealed a significant difference in the diameter of entry, number of radial fractures, diameter and thickness of mist zone with types of glass.
Kerguelen Plume Drives the Eocene Directional Change in Australian Plate Motion
Authors: Stotz Ingo L. , Carena Sara , Vilacı́s Berta , Hayek Jorge N. , Bunge Hans-Peter
Published: September 2024

Australia undergoes a directional plate motion change from westward to northward motion in the early Cenozoic that is associated with Australia/Antarctica separation. At the same time, there is evidence for early Cenozoic growing dynamic topography in the western part of the continent, which we infer by mapping geological hiatus—suggesting a high-pressure source in the upper mantle to the west of Australia. Plate motion changes can be used to better constrain the torques that drive plate tectonics. Such changes in motion need adjustments in either the torques exerted at plate boundaries or basal shear stresses. Furthermore, changes in the direction plate motion are useful to pinpoint torque locations. In particular, basal shear stresses can be understood in terms of Poiseuille flow. In this context, active driving asthenosphere torques arise from pressure gradients in the asthenosphere. Thus, Poiseuille flow inherently connects both horizontal and vertical plate motions, including dynamic topography. Mantle plumes generate positive pressure gradients in the asthenosphere, which is evident from elevated dynamic topography in regions with plume activity. Here, we apply a simple Poiseuille flow model to demonstrate that the Kerguelen plume is precisely located to provide the torque to initiate the early Cenozoic directional change of Australian plate motion; these results are entirely consistent with the hiatus occurrence in the western half of the continent at that time. Our findings point out the feasibility of identifying torque sources from active upper mantle flow that can account for shifts in the direction of plate motions.
Similarity in the microbial community structure of tobacco from geographically similar regions
Authors: Li Zhengfeng , Qin Tian , Xia Yuzhen , Zhou Le , Wang Luoping , Duan Kai , Lei Jia , Yao Jianhua , Xia Jianjun , Li Juan
Published: September 2024

To investigate the structural and functional similarities of microbial communities in burnt-sweetness alcoholized tobacco as a function of distance from the equator and their effects on tobacco quality, we sampled alcoholized tobacco from Chenzhou, Hunan Province, China and from Brazil and Zimbabwe, which are also burnt-sweetness-type tobacco producing regions, and performed high-throughput sequencing of tobacco bacterial and fungal communities along with an analysis of the main chemical constituents of the tobacco to analyze differences in the quality of the tobacco and similarities in the structure of the microbial communities. The total nitrogen, nicotine and starch contents of Chenzhou tobacco were greater than those of Brazilian and Zimbabwean tobacco, and the total sugar and reducing sugar contents of the Brazilian and Zimbabwean tobacco were greater than those of the Chenzhou tobacco (P < 0.05). The alpha diversity indices of the bacterial communities in Chenzhou tobacco were lower than those in the Brazilian and Zimbabwean tobacco, and the alpha diversity indices of the fungal communities in Chenzhou tobacco were greater than those in the Brazilian and Zimbabwean tobacco (P < 0.05). In the ecological networks, bacterial–fungal interactions in the Brazilian and Zimbabwean tobacco were more complex than those in the Chenzhou tobacco, and the microbial ecological networks of the burnt-sweetness-type tobacco from three different regions were dominated by competitive relationships. The microbial community composition of Chenzhou tobacco was similar to that of Brazilian tobacco at the bacterial genus and fungal phylum level, with Sphingomonas being a significantly enriched genus in Brazilian tobacco and a key genus in the Chenzhou network that is able to participate in the degradation of polyphenols and aromatic compounds. Functional microbes related to aromatic compounds and cellulose degradation were significantly more abundant in the Brazilian and Zimbabwean tobacco than in Chenzhou tobacco, and the related degradation of tobacco substances was responsible for the better quality of the Brazilian and Zimbabwean tobacco. In conclusion, there are similarities in the structure, composition and functional flora of microbial communities in tobacco from Chenzhou and Brazil because these regions have similar latitudinal distributions. This study provides theoretical support for selecting cultivation regions for the burnt-sweetness-type alcoholized tobacco and for the alcoholization of tobacco leaves.
Half-dosage of gonadotropin-releasing hormone agonist is effective for pituitary desensitization during short IVF protocol
Authors: Hsieh Jen-Hsiang , Chang Chi-Chen , Hsieh Yao-Yuan , Li Chang-Wei
Published: September 2024

Objectives
Gonadotropin-releasing hormone agonist (GnRHa) has been used for pituitary desensitization during controlled ovarian hyperstimulation (COH)-IVF for decades. We aimed to determine the clinical differences of half-dosage leuplin accete (LA) with the full-dosage in pituitary desensitization during short protocol COH.
Methods
All COH-IVF individuals who accepted LA for pituitary down-regulatioin were recruited. Women were divided: (1) LA 0.5 mg/day (age < 38, n = 32); (2) LA 0.25 mg/day (age < 38, n = 38); (3) LA 0.5 mg/day (age ≥38, n = 30); (4) LA 0.25 mg/day (age ≥38, n = 33). The gonadropin dosage, LH surge, OHSS risk, oocyte and embryo No., clinal pregnancy rate (CPR), and live birth rate (LBR) between each group were compared. The trial registration number and date of registration trial were retrospectively collected.
Results
The non-significantly trends of lower gonadotropin dosages and higher LH surges in the half-dosage GnRHa groups compared to full-dosage GnRHa groups were observed. Gonadotropin dosages (IU)/ E2 (pg/mL) on hCG day/LH surges in each group were: (1) 1454.4/1653.6/0%; (2) 1419.6/1683.5/3%, (3) 1954.5/910.8%/0%; and (4) 1893.5/953.6/3.7%; respectively. The oocyte No., day3 embryo No., ovarian hyperstimulation syndrome (OHSS), and CPR, LBR between half and full dosage were not statistically different between full & half LA groups. The oocyte No./day3 grade I, II embryo No/CPR/LBR in each group were: (1) 11.3 /5.6/37.5%/31.3%; (2) 11.8/5.1/39.4%/33.3%, (3) 6.5/2.6/19.2%/11.5%; and (4) 6.8/2.7/22.2%/14.8%; respectively.
Conclusions
Half-dosage GnRHa application results in comparable pituitary suppression and clinical outcomes compared to full-dosage GnRHa during short IVF protocol. The real roles of lower-dosage GnRHa upon pituitary desensitization during IVF warrant further investigation.
Research on Spatial Differentiation of Chinese High-level Athletes and Its Influence Mechanisms - Analysis Based on GIS and QCA
Authors: Chengwei Xu , Shi Bing
Published: September 2024

The spatial distribution of high-level athletes is one of the important indicators for judging the development of regional competitive sports. In this study, the regional distribution characteristics of high-level athletes and their influencing mechanisms in 31 provinces in mainland China were analyzed using GIS and QCA methods. The results show that: (1) there is a significant imbalance in the distribution of high-level athletes in different regions, showing a distribution pattern of more in the east and less in the west, dense along the coast and sparse in the inland; (2) there is a positive spatial correlation in the distribution, which shows the complexity of imbalance and dynamic adjustment, and maintains the overall pattern of low-level imbalance; (3) there are four types of paths contributing to the phenomenon of regional agglomeration, which belong to the categories of "technology-environment type" and "technology-environment type", which include core conditions such as investment in science and technology innovation, coaching resources, regional economic strength, and social sports organizations, and specific combinations of auxiliary conditions such as sports events, sports reserve talents, and professional sports development. The study shows that coaching resources are the core factor in all groupings.
Causal mapping of a midbrain circuit supporting 3-D vision in humans and monkeys
Authors: Friedrich Maximilian , Horn Anja , Das Vallabh , Rucker Janet , Hiew Shawn , Mayadali Ümit , Peach Robert , Butenko Konstantin , Eldebakey Hazem , Hartig Johannes , Friedrich Helen , Ip Chi Wang , Volkmann Jens , Zeller Daniel , Changizi Barbara , Dieterich Marianne , Zee David , Zwergal Andreas , Reich Martin , Fox Michael
Published: September 2024

Frontal-eyed species use a combination of conjugate and vergence eye movements, termed 3-D gaze, to scan their environment1–3. The neural circuits mediating conjugate gaze have been extensively characterized, but those governing vergence remain disproportionately obscure4. Here, we combine lesion and deep brain stimulation data from 67 humans and 19 monkeys to causally link vergence function to a midbrain region rostral to the superior colliculus, encompassing the nucleus of the posterior commissure (NPC), and aligning with the location of neurons whose activity correlates with vergence in monkeys5,6. Cross-species eye movement analysis suggests the NPC region houses a vergence integrator maintaining stable eye alignment in depth5,7,8. Multimodal connectivity revealed NPC connections to the pretectum and the supraoculomotor area, brain regions previously linked to visual maps of 3-D space and premotor control of the near response, enabling focus across varying viewing distances9. Collectively, these results suggest the NPC region is a key node for 3-D visuomotor transformations. These findings bridge a translational gap between physiological observations in monkeys and clinical disorders in humans, revealing a subcortical circuit for 3-D vision.
Physical Activity Level Effect on Cognitive Level And Quality Of Life in Patients with Breast Cancer: A Case Control Study Investigation Of The Relationship Between Physical Activity Level And Quality Of Life In Patients With Breast Cancer
Authors: KAHRAMAN Ayşegül , ÖZTÜRK Nazan , KARABIÇAK Gül Öznur , OKTAY Esin
Published: September 2024

Purpose
To determine the level of physical activity, quality of life and cognitive level in patients undergoing breast cancer treatment and to compare the results with a healthy population of similar age group.
Methods
Our case-control study was conducted with chemotherapy patients (CG) diagnosed with breast cancer (breast Ca) treated in the Department of Oncology and healthy control group (HCG) with similar demographic characteristics. he participants' physical activity level was assessed using the International Physical Activity Questionnaire (IPAQ), their quality of life using the EORTC-QLQC30 Quality of Life Scale, and their cognitive level using the Montreal Cognitive Assessment Scale. The Mann-Whitney U test was used to determine differences between groups. A level of p < 0.05 was considered statistically significant.
Results
In our study in which breast Ca (n = 38, age = 52.96 ± 11.37 years, height = 162.22 ± 6.28cm, weight = 71.07 ± 12.91kg, chemotherapy cycle = 4.33 ± 6.86 cycles) and healthy control group (n = 30, age = 51. 1 ± 12.39 years, height = 161.63 ± 6.33cm, weight = 70.23 ± 12.761kg), the physical activity level was significantly lower in the breast cancer group than in the control group (p < 0.0001, z=-4.101). Similarly, the cognitive level (p < 0.0001, z=-3.258) subscores were significantly lower in the breast ca group compared to the control group. While the overall quality of life score did not differ from healthy controls (p < 0.0001, z=-4.101), the physical, social, emotional, fatigue and vomiting subscores were significantly lower than healthy controls.
Conclusion
The level of physical activity was found to be lower in patients after breast cancer compared to their healthy counterparts. In addition, levels of social support and role functioning, which indicate quality of life, and disease-specific symptoms such as pain, nausea, vomiting, and constipation were different from those in the healthy control group. Therefore, these variables should be taken into account in the exercise programme given to breast cancer patients.
Clinical Trial Registration number: NCT05275517 Submission Date: 05/09/2023
A Novel Hybrid Ant Colony Ant lion optimization for allocation and sizing of DFACTS in Real-time reconfigured distribution system for security enhancement
Authors: Sri K , P. Mangaiyarkaras S. , Balakumar S , Jebaraj L
Published: September 2024

Power generation and distribution are vital processes as all loads in today's utilities are energized by the power they provide. So, delivering it efficiently is a challenging and unfulfilled task. Achieving a fully efficient distribution is still an ongoing research process. Various factors are studied and improved with the obtained results. In this paper, the optimal radial distribution network is examined, and according to our results, reconfiguration is done using a hybrid Ant Colony – Ant Lion Optimization Algorithm (HACALOA). Single incoming substation is utilized through a series of step downs and splits to achieve a balanced load. To investigate the competence of the planned method, the IEEE 33-bus system and 35-bus Indian utility system are implemented in real time using MATLAB. An analogy is made to prove the effectiveness of the planned method from the outcomes obtained using various techniques.
Stronger, Straightforward Service and Support Provision: A New Methodological Approach to Infant and Early Mental Health Care Pathway Creation Through Multisectoral Collaboration
Authors: Peterson-Katz Karys , Davis Amanda , Summers Nicole , Kulkarni Chaya , Sundar Purnima , Reynolds James N.
Published: September 2024

Background:
Early childhood plays a pivotal role in shaping positive mental health outcomes, yet navigating the path to appropriate services in Ontario is often hindered by fragmented systems, lack of collaboration, and unclear pathways to care.
The Infant and Early Mental Health (IEMH) Care Pathways Initiative addresses the critical need for accessible and comprehensive mental health support for at-risk children under the age of 6 in Ontario.
This paper outlines the IEMH Care Pathways methodology to develop and implement systems of care pathways that lead families with children 0-6 to, through, and out of care.
Methods:
The IEMH Care Pathways Initiative employs a 5-phased approach: 1) Community Engagement, 2) Service Mapping and Inventory Assessment, 3) Aspirational Pathway Building, 4) Ages and Stages Questionnaire and Developmental Support Plan Training and Implementation, and 5) Aspirational Pathway Implementation. Evaluation throughout the process is informed by the Consolidated Framework for Implementation Research.
Conclusions:
The IEMH Care Pathways methodology represents a significant step forward in promoting positive mental health outcomes and overall well-being for children before they reach school age. By prioritizing the science of brain development, early developmental delay identification, and access to timely and appropriate support services, the process presented aims to mitigate the risk of adverse outcomes and increase opportunities for positive developmental trajectories. Continued efforts to refine and expand upon the methodology outlined in this paper are underway. Through collaborative partnerships and equitable access to care, a more cohesive and effective system to ensure healthier communities can be created.
Indication of p + 11 B Reaction in Laser Induced Nanofusion Experiment
Authors: Kroó N. , Csernai L. P. , Papp I. , Kedves M. A. , Aladi M. , Bonyár A. , Szalóki M. , Osvay K. , Varmazyar P. , Biró T. S.
Published: September 2024

The NAPLIFE project proposed fusion by regulating the laser light absorption via resonant nanorod antennas implanted into hydrogen rich urethane acrylate methacrylate (UDMA) and triethylene glycol dimethylacrylate (TEGDMA) copolymer targets. In part of the tests, boron-nitride (BN) was added to the polymer. Our experiments with resonant nanoantennas accelerated protons up to 225 keV energy. Some of these protons then led to p + 11B fusion, indicated by the sharp drop of observed backward proton emission numbers at the 150 keV resonance energy of the reaction. The generation of alpha particles was verified by CR-39 plastic track detectors.
Albumin Nanoparticle enhances Oxaliplatin concentration in the Colorectal region to treat Colon Cancer with increased efficacy
Authors: Wilson Barnabas , KM Geetha , Divekar Kalpana , Jenita Josephine Leno , Premakumari Kudumula B. , Sagar Girisha
Published: September 2024

Site specific delivery of anticancer drugs into tumour cells increase therapeutic efficacy while decreasing unwanted side effects. Oxaliplatin (Oxa) is a third-generation platinum derivative used to treat advanced colorectal cancer (CRC). Oxaliplatin loaded bovine serum albumin nanoparticles (Nps-Bsa-Oxa) were formulated by desolvation method. The Nps-Bsa-Oxa were characterized for their size, zeta potential (ZP), surface morphology and charge, in vitro Oxa release, release kinetics, in vitro cytotoxicity, and in vivo studies. The size and surface charge of the Nps-Bsa-Oxa was found to be 163.2 ± 6.3nm and − 27 mV respectively. The Oxa release was studied by dialysis, revealing a biphasic release pattern. In vitro cytotoxicity study was carried out by MTT assay using HT29 cell lines and the Nps-Bsa-Oxa showed higher cytotoxicity when compared with free drug Oxa. In vivo studies on animals revealed that Nps-Bsa-Oxa delivered more Oxa to the colonic region compared to the free form of the drug Oxa.
Revision and Validation of the “Motivational Climate in Physical Education Scale” (MCPES) in Chinese educational context
Authors: zhang qiang , Sun Yingying , Fan Erzhen , Deng Wenjing
Published: September 2024

This study evaluated the reliability and validity of the Chinese version of the “Motivational Climate in Physical Education Scale” (MCPES) among middle school students. Data were collected from 1,010 students, with 473 completing the MCPES, the Physical Needs Support in Physical Education Scale (PNS-PE), and the Youth Sports Friendship Scale (YFQS). Additionally, 437 students completed only the MCPES, and 200 valid retest questionnaires were gathered three weeks later. Exploratory factor analysis identified four factors: perceived autonomy support, perceived social relationship support, perceived task involvement support, and perceived self-involvement support, with a total of 16 items. Confirmatory factor analysis supported the four-factor structure (χ2/df = 3.38, GFI = 0.92, NFI = 0.90, RMSEA = 0.07, CFI = 0.93, IFI = 0.93, SRMR = 0.05). The scale exhibited strict measurement invariance across genders and strong invariance across grade levels. It was positively correlated with teacher autonomy support (r = 0.34–0.53) and with each dimension and total score of sports friendship (r = 0.21–0.61). Cronbach’s α coefficients for the MCPES and its dimensions were 0.75, 0.82, 0.79, 0.80, and 0.88, respectively. Intraclass correlation coefficients (ICCs) for the three-week retest were 0.64, 0.63, 0.72, and 0.76. In conclusion, the Chinese version of the MCPES demonstrates robust reliability and validity for use with middle school students.
Global Solar Radiation Estimation from meteorological Temperature data for Samara City, Ethiopia
Authors: Anshebo Getachew Alemu
Published: September 2024

In this study, several regression models were employed to estimate global solar radiation from commonly available meteorological data such as temperature, for meteorological stations of samara city Afar region..A location's solar radiation availability is a crucial consideration when choosing the right solar energy system and accessories for a range of uses. The greatest and lowest temperatures recorded at Samara City (11..81°N, 41.16°E), over a five-year period (2013–2017) were utilized to create Angstrom-type regression equations, or models, for calculating the total solar radiation that Samara City received on a horizontal surface. In order to determine the effectiveness of the models, the correlation results were also checked for errors using statistical test methods such as mean bias error (MBE), root mean square error (RMSE), and mean percentage error (MPE). It was found that temperature data can be applied to calculate the total amount of solar radiation incident on a Samara City, with a very reasonable degree of precision.
Microwave irradiation as a novel strategy for mitigating airborne transmission of highly pathogenic avian influenza A(H5N1) virus: an optimization study
Authors: Bia Pietro , Losardo Margherita , Manna Antonio , Brusaferro Silvio , Privitera Gaetano P. , Vincentelli Alberto Sangiovanni
Published: September 2024

The highly pathogenic avian influenza A(H5N1) virus threatens animal and human health globally. Innovative strategies are needed to reduce airborne transmission and prevent outbreaks. This study investigated the efficacy of microwave inactivation against aerosolized A(H5N1) by (1) identifying the optimal frequency band in 10 min of exposure and (2) evaluating the effect of exposure time.
A(H5N1) was aerosolized and exposed to various microwave frequencies (between 8 and 16 GHz with different ranges) for 10 minutes. Viral titers were quantified using TCID50, and inactivation was assessed by comparing irradiated samples to controls. The 11−13 GHz band resulted in the highest inactivation, with an average of 89% mean reduction in A(H5N1) titer in particular in the range of 11-12 GHZ (pick of efficacy). Considering the overall tests and results, the optimal band (8-12 GHZ) was further tested with 1, 3, and 5-minute exposures. Inactivation was time-dependent, with 5-minute exposure yielding a 94% mean reduction, compared to 58% and 48% for 3 and 1-minute exposures, respectively. Optimized microwave emitters in high-risk environments like poultry farms and veterinary clinics could offer a novel, non-chemical approach to mitigating avian influenza spread and outbreaks.
Characterizing High-risk Population with Metabolic Syndrome based on Extreme Logistic Regression
Authors: Ling Chengxiu , Bai Long , Zhu Xiaojun , Shi Dongping , Wang Hongliang , Wu Han , Wang Kai , Zhou Feng , Wen Zhongmin
Published: September 2024

Metabolic syndrome (MetS), as a potential factor leading to diabetes and cardiovascular diseases, has attracted increasing global attention, especially on its identification and intervention.This study aims to characterize high-risk individuals with MetS based on an extreme logistic regression (ELR) model. Five key factors of waist circumference (WC), fasting plasma glucose (FPG), blood pressure (including systolic blood pressure (SBD) and diastolic blood pressure (DBP), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) are incorporated in an extreme function to predict the severity of MetS. The individuals with high-risk MetS are uniformly identified with the estimated cut-offs of predictors and prediction rules of the MetS population simultaneously. Typically, the identified individuals with higher-risk MetS under extreme diagnostic criteria are more likely to experience a greater burden of relevant diseases. We conclude that the innovative diagnosis criteria for MetS have significant implications for clinical warning, effective intervention strategies, and better resource allocation in clinical settings.