bluuebunny/crossref_metadata_2025 huggingface dataset:
LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation
Authors: Choi Chan Hee , Barr William , Park Annsea , Koenen Mascha , Lin Zeran , Szwed Sarah , Crane Audrey , Carroll Thomas , Molina Henrik , Cohen Paul
Published: July 2021

While dysregulation of adipocyte endocrine function plays a central role in obesity and its complications, the vast majority of adipokines remain uncharacterized. We employed bio-orthogonal non-canonical amino acid tagging (BONCAT) and mass spectrometry to comprehensively characterize the secretome of murine visceral and subcutaneous white and interscapular brown adipocytes. Over 600 proteins were identified, the majority of which showed cell type-specific enrichment. We here describe a metabolic role for leucine-rich α-2 glycoprotein 1 (LRG1) as an obesity-regulated adipokine secreted by mature adipocytes. LRG1 overexpression significantly improved glucose homeostasis in diet-induced and genetically obese mice. This was associated with markedly reduced white adipose tissue macrophage accumulation and systemic inflammation. Mechanistically, we found LRG1 binds cytochrome c in circulation to dampen its pro-inflammatory effect. These data support a new role for LRG1 as an insulin sensitizer with therapeutic potential given its immunomodulatory function at the nexus of obesity, inflammation, and associated pathology.
Perceptions on Impacts of Competition of Eucalypt Plantations with Other Land Uses on the Rural Livelihood in the Western Gurage Watersheds, Central-South Ethiopia
Authors: Zerga Belay , Warkineh Bikila , Teketay Demel , Woldetsadik Muluneh
Published: July 2021

Since recent years, conversions of croplands, grasslands or cash crop fields to eucalypt plantations are becoming common trends in Ethiopia. Reasons for the conversions are better return from eucalypt than crop farming. This study tried to assess the land use competition impacts of eucalypt plantations with other land uses in the Western Gurage Watersheds, Central-south Ethiopia. The specific objectives were to investigate households’ and experts’ perceptions on land use competition of eucalypt plantations; and to assess perceptions on impacts of eucalypt plantation and copping strategies. Samples from three woredas (districts) namely Cheha, Enemorna Ener, and Eza located in the Watersheds were used. These woredas were purposefully selected due to large coverage of the watersheds, extensive expansion of eucalypts farming and thereby high eucalypts pole production, incidences of serious competition of eucalypts with other uses, and the presences of road accessibility for data collection. To get detail information on perception of the households and experts, in-depth discussions with focus groups and key informant were employed. Individual farm households whose age were greater than 70 years old and knowledgeable persons to discuss on the issue of eucalypt plantations were selected purposefully with the guidance of each kebele (sub-district) chairpersons and district experts. Thereafter, three focus group discussions with farm households were conducted in the three districts. Key informant interviews were conducted with purposefully selected and well experienced individual farm households and experts in each district. The result showed that young farmers planted from 1000 to 5000 eucalypt seedlings on lands previously covered with crops. The young people resisted advice from elders and converted farmlands to eucalypt plantations. Previous practitioners (adoptees) who benefitted much from eucalypt products tended for further expansion. This, in turn, resulted in serious land use competition with farmland and grasslands. To mitigate such serious competition with food crops and grasslands, and to sustain the livelihood and environment, appropriate management, e.g. site selection and substitutions by horticultural and cash crops using micro irrigation schemes for market needs are recommended. Conducting in-depth participatory research and specific policy ratification and promulgation on eucalypt plantations will curb its serious land use competition with farm and grazing lands.
Title Prevalence of Bartonella Species in Shelter Cats and their Ectoparasites in Southeastern Brazil
Authors: Raimundo Juliana M. , Guimarães Andresa , Amaro Gleice M. , Silva Aline T. da , Rodrigues Caio Junior B. C. , Santos Huarrisson A. , de Lemos Elba R. S. , Favacho Alexsandra R. de Mendonça , Baldani Cristiane Divan
Published: July 2021

Background: Feline Bartonella can be transmitted to humans through cat scratches or bites, and between cats by Ctenocephalides felis flea. Methods: The occurrence of Bartonella DNA was assessed in ectoparasites and their cat hosts living in shelters based on the ITS region and gltA gene. Results: Bartonella DNA was detected in 47.8% of cat blood samples, in 18.3% of C. felis fleas,13.3% of flea eggs pools and 12.5% of lice pools. B.henselae and B. clarridgeiae DNA were detected in cat fleas, while B. henselae, B. clarridgeiae, and B. koehlerae in blood samples from bacteremic cats. Cats infested by positive ectoparasites showed approximately twice the chance of being infected. Conclusions: Our results indicate shelter cats have a high prevalence of Bartonella species known to be human pathogens and highlight the importance of controlling their infestation by ectoparasites to avoid cat and human infection.
Willingness to Pay for Breast Cancer Screening by Providing Basic and more Complete Information
Authors: Moeeni Maryam , Rahmani Shiva , Yousefi Mahmood , Nosratnejad Shirin
Published: July 2021

Background: Mammography screening is the most sensitive and specific test that can be conducted along with the clinical examination for the early diagnosis of breast cancer. However, like other tests, mammography screening is not a perfect test and has some limitations. The purpose of the present study is to measure women’s willingness to pay for breast cancer screening with mammography by providing them with basic and more complete information.Method: In this study, 450 women aged 35-55 years were assigned into two groups of equal numbers. The first group was provided only with the basic information on 225 women, while the other group was provided with more complete information. The double bounded dichotomous choice method was used to extract women’s willingness to pay for mammography screening.Result: The mean willingness to pay for breast cancer screening with mammography was estimated as 26.14$ in the group receiving basic information and 21.41$ in the group receiving complete information.The results of interval regression analysis reported age of woman at the time interview, her occupation status, her education status, whether or not she had complementary insurance, and her prior experience of mammography as correlates of willingness to pay for mammography screening. Conclusion: The more women have knowledge about all aspects of mammography screening, the more they are ready to utilize it. The results suggest the women can balance the possible benefits of mammography screening against its demerits.
Altered Plasma Fatty Acids Associate with Gut Microbial Composition in Common Variable Immunodeficiency
Authors: Skarpengland Tonje , Macpherson Magnhild E , Hov Johannes R. , Kong Xiang Y. , Bohov Pavol , Halvorsen Bente , Fevang Børre , Berge Rolf K. , Aukrust Pål , Jørgensen Silje F.
Published: July 2021

Purpose: Fatty acid (FA) abnormalities have been found in various inflammatory disorders and have been related to disturbed gut microbiota. Patients with Common variable immunodeficiency (CVID) have inflammatory complications associated with altered gut microbial composition. We hypothesized that there is an altered FA profile in CVID patients, related to gut microbial dysbiosis. Methods: Plasma FAs were measured in 39 CVID patients and 30 healthy controls. Gut microbial profile, a food frequency questionnaire and the effect of the oral antibiotic rifaximin, were investigated in CVID patients. Results: The n-3 PUFAs, EPA (1.4 [1.0-1.8] vs 1.9 [1.2-2.5], median [IQR], P<0.05) and DHA (3.2 [2.4-3.9] vs 3.5 [2.9- 4.3], P<0.05) were reduced in CVID compared to controls. Also, n-6 PUFAs (34.3 ± 3.4, vs 37.1 ± 2.8, mean ± SD, P< 0.001) and linoleic acid (LA) (24.5 ± 3.3, vs 28.1 ± 2.7, P< 0.0001), and the FA anti-inflammatory index (98.9, [82.1-119.4], vs 117.0, [88.7-153.1], median [IQR]), P<0.05) were reduced in CVID. The microbial alpha diversity was positively associated with plasma n-6 PUFAs, (r=0.41, P<0.001) and LA (r=0.51, P<0.001), but not n-3 PUFAs (P= 0.78). Moreover, a 2-week course of rifaximin significantly reduced the proportion of n-6 PUFAs (P=0.04, UNIANOVA). Overall, the altered proportions of n-3 and n-6 PUFAs did not seem to be related to dietary intake, intestinal malabsorption or presence of CVID enteropathy.Conclusion: We found a potentially unfavourable FA profile in CVID, where plasma proportion of n-6 PUFAs was related to gut microbial diversity and altered by microbial therapy.
Dietary Use of Artemisia Herba Alba Asso as A Potential Coccidiostat Against Cæcal Coccidiosis: Haematological Parameters Variations.
Authors: MESSAÏ Ahmed , REDOUANE-SALAH Sara
Published: July 2021

This study consists of the evaluation of the anticoccidial effect of Artemisia herba-alba Asso during experimental coccidial infection. Four groups of 30 broiler chickens were formed: the negative control (G1), the positive control (G2), the infected Monensin-treated group (G3), and the infected Artemisia-treated group (G4). Each infected bird received orally 105 sporulated oocysts of Eimeria tenella. No mortality was recorded in both G1 and G4. Haematocrit levels showed great variations from the 7th day Post-Infection, especially in G2 (20.87%±5.77). By day 10 P-I, haematocrit recovery was rapid particularly in G4 (28.07%±1.50). Haemoglobin concentration also decreased significantly (p<0.05) in all infected groups by the 7th day P-I. The reduction was very marked in G2 (6.47g/dL±1.67) against (10.53 g/dL ±0.25) in G1, but less marked in G4 (8.05g/dL ±1.56). Results show the protective effect of A. herba-alba Asso by improving the lesion score and the haematological parameters affected during coccidian infection.
Association of Antibiotics Exposure Within the First 2 Years After Birth with Subsequent Childhood Type 1 Diabetes
Authors: Lee Dahye , Choi Seulggie , Chang Jooyoung , Park Young Jun , Kim Jae Hyun , Park Sang Min
Published: July 2021

Purpose: Antibiotics prescription in early life can cause dysbiosis, an imbalance of gut microbiota. We aimed to reveal the relationship between antibiotics exposure during the first 2 years after birth and type 1 diabetes risk in children under 8 years of age using a nationally representative data from South Korea. Methods: The final study population consisted of 63,434 children from the National Health Insurance Service (NHIS) database from 2008 to 2015. The primary exposure of interest was antibiotics prescription in first 2 years after birth. The analysis was conducted with cumulative defined daily dose (cDDD; 0-29, 30-59, ≥ 60 cDDD), the number of antibiotics classes (0-3, 4, ≥ 5 classes), and age at first antibiotics prescription (0-119, 120-239, ≥ 240 days). Age, sex, household income, and overweight were considered as potential confounding covariates. Results: Compared to those within the less than 30 cDDD, other groups that were prescribed more antibiotics did not have a significant difference in diabetes risk (aHR 0.86, 95% CI 0.37-2.02 in ≥ 60 cDDD). The number of antibiotics classes and age at first antibiotics prescriptions were also not associated with the risk of type 1 diabetes. The development of diabetes was not related to the cDDD, the number of antibiotics classes, and age at first antibiotics prescription according to subgroup analysis which was stratified by overweight. Conclusions: Antibiotics exposure within the first 2 years of life was not associated with subsequent diabetes risk. Future studies using a larger number of long-term follow-up data are needed.
Effect of Multifocal Intraocular Lens on Contrast Sensitivity in Primary Angle-Closure Patients
Authors: Kitnarong Naris , Dagvadorj Dovchinjamts
Published: July 2021

Introduction: Cataract surgery with intraocular lens (IOL) implantation in primary angle-closure glaucoma (PACG) has been reported to improve visual acuity, and to reduce postoperative intraocular pressure (IOP) and the number of required medications. Few studies have reported the use of multifocal IOL (MIOL) in PACG. Since both MIOL and glaucoma can decrease contrast sensitivity (CS), this study was to evaluate the effect of MIOL implantation on CS compared to monofocal IOL (mIOL) in primary angle-closure (PAC) or PACG.Methods: This prospective study included patients with PAC or PACG and visually significant cataract. Phacoemulsification with MIOL or mIOL (patient preference) was performed. Collected data included best-corrected distant visual acuity (BCVA), intraocular pressure (IOP), anterior chamber depth (ACD), and contrast sensitivity (CS) measured at spatial frequency 1.5, 3.0, 6.0, 12.0, and 18.0 cycles per degree (CPD) preoperatively, and at 2-6 months postoperatively. Preoperative and postoperative parameters were then compared. Results: Of the 45 eyes from 35 patients that were enrolled, 33 eyes (15 PAC, 18 PACG) from 26 patients completed the study. Fourteen eyes (11 patients) received diffractive MIOL, and 19 eyes (15 patients) received aspheric mIOL. Preoperative CS was not significantly different between groups. Postoperatively, BCVA, and CS at each spatial frequency were significantly improved in both groups (all p<0.001). Mean postoperative CS at spatial frequency 1.5, 3.0, 6.0, 12.0, and 18.0 CPD was 28.03, 42.63, 44.84, 10.82, and 2.86 in the MIOL group, and 29.55, 49.63, 46.20, 16.83, and 7.09 in the mIOL group, both respectively. Postoperative CS was not significant different between groups at any spatial frequencies. IOP was decreased (p=0.001) and ACD increased (p<0.001) postoperatively in both groups. Conclusion: No significant difference in contrast sensitivity was observed between MIOL and mIOL after cataract removal in PAC/PACG. Multifocal IOL can be considered in primary angle-closure eyes.
Synthesis of Bioactive Fluoropyrrolidines via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides
Authors: Xu Xiao , Bao Longzhu , Ran Lu , Yang Zhenyan , Yan Dingce , Wang Chun-Jiang , Teng Huailong
Published: July 2021

Chiral pyrrolidinyl units are important building blocks in biologically active natural products and drugs, thereupon, searching approaches for the synthesis of diverse structured pyrrolidine derivatives is of great importance. Meanwhile, owing to the special physicochemical properties of fluorine atoms, the introduction of fluorine containing groups into small molecules often change their activities to a great extent. Herein, we reported an efficient route to chiral 3,3-difluoro- and 3,3,4-trifluoropyrrodinyl derivatives by Cu(I)-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides with less active 1,1-difluoro- and 1,1,2-trifluoroalkenes. A series of new fluorinated pyrrolidines have been prepared in high yields (up to 96%) and excellent stereoselectivities (up to > 20:1 dr and 97% ee), and these unique structural blocks could be readily introduced into some natural compounds and pharmaceuticals. Additionally, antifungal activity investigation against four common plant funguses showed that some products possess general and high biological activities (up to 93% inhibition rate), the comparison with the antifungal activities of corresponding non-fluorinated compounds (low to 13% inhibition rate) revealed that the fluorine atoms at pyrrolidinyl rings play a crucial role in the antifungal activity, which prove the special properties of fluorine atoms in organic molecules.
The role of predator removal by fishing on ocean carbon dynamics
Authors: Stafford Rick , Boakes Zach , Hall Alice , Jones Georgia
Published: July 2021

The ocean is a net sequester of carbon dioxide, predominantly through low biomass, high productivity phytoplankton photosynthesis. Selective removal of predatory fish through extractive fishing alters the community structure of the ocean, with an increased biomass of more productive, low trophic level fish and higher overall respiration rates, despite possible decreases in total fish biomass. High pressure fishing on predators may result in as much as a 19% increase in respiration from fish communities and could prove highly significant in global carbon budgets.
Design and Synthesis of Fluorophore-Tagged Disparlure Enantiomers to Study Pheromone Enantiomer Discrimination in the Pheromone-Binding Proteins from the Gypsy Moth, Lymantria Dispar.
Authors: Pinnelli Govardhana R. , Plettner Erika
Published: July 2021

Fluorescent analogues of the gypsy moth sex pheromone (+)-disparlure (1) and its enantiomer (-)-disparlure (ent-1) were designed, synthesized and characterized. The fluorescently labelled analogues 6-FAM (+)-disparlure 1a 6-FAM (-)-disparlure ent-1a were prepared by copper-catalyzed azide-alkyne cycloaddition (CuAAC) of disparlure alkyne and 6-FAM azide. These fluorescent disparlure analogues 1a ent-1a were used to measure the disparlure binding to two pheromone-binding proteins from the gypsy moth, LdisPBP1 and LdisPBP2. The fluorescence binding assay using 6-FAM disparlure enantiomers 1a and ent-1a showed that the LdisPBP1 and LdisPBP2 have different binding affinities with 1a and ent-1a. The LdisPBP1 has stronger affinity for 6-FAM (-)-disparlure ent-1a, whereas LdisPBP2 has stronger affinity for 6-FAM (+)-disparlure 1a, consistent with the findings from previous study with disparlure enantiomers. The 6-FAM disparlure enantiomers appeared to be much stronger ligands for LdisPBPs, with the binding constant (Kd) in nanomolar range, compared to the fluorescent reporter such as 1-NPN (which had Kd values in micromolar range). The fluorescence competitive binding assays were used to determine the displacement constant (Ki) for the disparlure enantiomers in competition with fluorescent disparlure analogues binding to LdisPBP1 and LdisPBP2. The Ki data showed that disparlure enantiomers can effectively displace the fluorescent disparlure from the binding pocket of LdisPBPs.
Validation of a two-layer depth-averaged model by comparison with an experimental dilute stratified pyroclastic density current
Authors: Shimizu Hiroyuki A. , Koyaguchi Takehiro , Suzuki Yujiro J. , Brosch Ermanno , Lube Gert , Cerminara Matteo
Published: July 2021

Numerical results of a two-layer depth-averaged model of pyroclastic density currents (PDCs) were compared with an experimental PDC generated at the international eruption simulator facility (the Pyroclastic flow Eruption Large-scale Experiment; PELE) to establish a minimal dynamical model of PDCs with stratification of particle concentrations. In the present two-layer model, the stratification in PDCs is modeled as a voluminous dilute turbulent suspension layer with low particle volume fractions (<10-2) and a thin basal bedload layer with high particle volume fractions (~10-2) on the basis of the source condition in the experiment. Numerical results for the dilute layer quantitatively reproduce the time evolutions of the front position and body thickness of the dilute part in the experimental PDC. The numerical results of the bedload thickness and deposit mass depend on an assumed value of mean deposition speed at the bottom of the bedload (D). We show that the thicknesses of bedload and deposit in the simulations agree well with the experimental data, when D is set to about 3.5 x 10-4 m/s. This value of the deposition speed is two orders of magnitude smaller than that predicted by a hindered-settling model. The small value of D suggests that the erosion process accompanied by saltating/rolling of particles plays a role in the sedimentation in the bedload.
Universal Health Coverage Development in Thailand: How Global Ideas and a National Medical Professional Movement Made a Difference
Authors: Sukhampha Rangsan
Published: July 2021

Background: Universal health coverage is endorsed as the global development agenda in the 2015 SDGs for global achievement by 2030 and is expected to build national policymaking agendas. Common research often focuses on national processes in the first place. For example, accounts of Thailand's health system development mostly emphasise domestic factors and influences rather than the linkage of external/global health ideas. The paper questions how external/global health ideas influence national health policymaking and the linkage between them in achieving Thailand's universal health coverage policy.Methods: A qualitative method was employed to capture complex and historical narratives of the national medical professional movement for Thailand's health system reform through the lens of a global social policy approach for exploring external and global health ideas transfer. Moreover, the actor- and policy entrepreneur approaches would be employed to investigate national health policymaking and examine how ideas from the external and global levels have improved national equity in health. Results: The research locates the narratives on global ideas and practices that influence a national health system reform. This highlights the impact/role of global ideas on national professional movements, i.e. the rural doctor movement in Thailand mobilising the health system reform for all. The study found that national equity in health could not be achieved without external/global health ideas transfer. Such a case of national universal health coverage achievement in Thailand happened with the effort of the rural doctor movement and individual agency as policy entrepreneurs in translating external/global ideas and practices for their movement and mobilisation. The case contributed to a better understanding of the global process regarding ideas and practices that can be transferred directly and indirectly to the national level. Conclusions: Global ideas transfer can also happen in different aspects such as it can be seen the ideas transfer from developed to developed countries; from developed to developing countries. Besides, the author witnessed that the IOs ideas can also be transferred to developing countries or reverse, and again, between developing countries themselves.
Parent-Young People Communication on Sexual and Reproductive Health Issues and Associated Factors Among Students in Agaro Town, Ethiopia: A Cross-sectional Study
Authors: Abdissa Daba , Sileshi Workitu
Published: July 2021

BackgroundSexual and reproductive health (SRH) is at the base of young people's living and wellbeing. A significant number of young peoples are affected by avoidable SRH problems due to a lack of appropriate knowledge regarding SRH. Parent-young communication on SRH is critical in informing them about risk and protective behaviors which in turn decrease the likelihood of involvement in risky sexual behaviors. Therefore, the purpose of this study was to evaluate the parent-young communication on SRH issues among secondary and preparatory school students at Agaro town, Southwestern Ethiopia. MethodsSchool based cross-sectional study was conducted from April 13 to April 20, 2019 using stratified random sampling technique. Data were collected using pretested interviewer-administered structured questionnaire entered into Epi data version 3.1; and analyzed using SPSS version 20. A variable having a p-value of <0.25 in the bivariable logistic regression model was subjected to multivariable logistic regression analysis to avoid the confounding variable’s effect. Adjusted odds ratios were calculated at the 95% confidence interval and considered significant with a p-value of <0.05.ResultsA total of 315 students were included to the study. The mean age of the respondents was 20.2±2.6 years. The study finding showed that 61.3% of the participants were discussed on SRH issues with their parents. Educational status of mother [primary education (AOR=3.67; 95%CI=1.93,6.97),secondary education(AOR:2.86;95%CI=1.20,6.80)],educational status of father[primary education (AOR=5.8;95%CI=2.8,12.3,secondary education (AOR=3.21; 95%CI=1.55,6.59)],having family size of <5 (AOR= 6.4; 95%CI= 3.36,12.37) and having boy/girlfriend(AOR=1.99; 95%CI=1.0,3.8) were significantly associated with parent-young people communication. ConclusionAbout two third of the participants communicate with their parents about SRH issues. Parents’ educational status, family size of <5 and having boy/girlfriend were significantly associated with the parent-young people communication. The main reasons for not communicated was cultural taboos, shame and parents lack of knowledge. Therefore, it is necessary to educate and equip students and parents to address the identified problems.
Ubiquitous Internet of Medical Things on Interoperable Ssn Ontology Platforms for E-Health Monitoring of Connected Objects
Authors: Gorrepati Rajani Reddy , Kim Do-Hyeun , Guntur Sitaramanjaneya Reddy
Published: July 2021

Ubiquitous Internet of medical things (U-IoMT) technology is designed to predict the efficiency and quality of health care facilities by using various connected objects to support patient monitoring systems. U- IoMT is connected to devices such as RFID tags and several physical sensor devices (WSN) that collect real-time information. This technology is used to comprehend complex security-related tasks. The ubiquitous platform can be used to access smart health care information through mobile and electronic devices, allowing for faster diagnosis and higher service quality. In this study, we use ontology to describe the semantic representation of medical objects and their data in U-IoMT backup in this analysis. The healthcare system aims to examine patient prescriptions and drug supply chain management records. Emergency healthcare services are connected to smartphone-wearable devices of patients for monitoring purposes to reduce emergency cases and to maintain e-patient records. The mobile health application aims to maintain the health status of a patient wherever the patient is located. The semantic sensor networks (SSN) architecture uses peer-to-peer communication to achieve semantic interoperability, which is described as interoperable IoMT platforms. A framework of SSN and the context-awareness layer was additionally created for visualization of patient remote health monitoring, drug management, patient moment analysis, and patient tracking were monitored using various devices, e-health was used to demonstrate the chronic diseases.
Sybil Attack with RSU Detection and Location Privacy in Urban VANETs- an Efficient EPORP Technique
Authors: Velayudhan Nitha C , A Anitha , Madanan Mukesh
Published: July 2021

Nowadays, Vehicular ad hoc networks (VANETs) has received interest in the research because it is used to provide the information for drivers and passengers. In the urban VANET, security and safety is a main issue in recent days because of different kinds of attacks. From the attacks, Sybil attack can be considered as a very difficult for urban VANET networks. Hence, in this paper Emperor Penguin Optimization based Routing protocol (EPORP) is developed for detecting the Sybil attack as well as increasing the system performance. The main objective of the research is detecting the Sybil attack as well as improve the security in VANETS. The initial objective is achieved with the help of Rumour riding technique which detect the Sybil attack in the urban VANET. Similarly, the security of the system is achieved with the help of Split XOR (SXOR) operation. In the SXOR operation, the optimal key is generated with the assistance of Emperor Penguin Optimization (EPO). The proposed method is implemented in NS2 platform and performances are evaluated by metrics such as delay, throughput, delay, encryption time and decryption time. The proposed method is compared with existing methods such as Whale Optimization Algorithm (WOA), Particle Swarm Optimization (PSO) and Firefly Algorithm (FA) respectively. While analyzing the delivery ratio, the proposed method has 0.96sec and the WOA, PSO and FA is 0.94, 0.92 and 0.90 respectively. From the analysis, the proposed method has the high delivery ratio value compared with the WOA, PSO and FA methods. Similarly, the other parameters are analyzed and compared with the existing methods.
Sevoflurane Exposure of Clinical Dose in Pregnant Rat Induces Vcan Changes Without Significant Neural Apoptosis in the Offspring
Authors: Jin Yi , Wei Yu , Hu Xiaoxue , Meng Fanhua , Luo Qing , Chen Zhilan , yang zeyong
Published: July 2021

Background: Sevoflurane is a commonly used inhalational anesthetic in clinic. Prolonged exposure to sevoflurane can induce significant changes in lipid metabolism and neuronal damage in the developing brain. However, the effect of sevoflurane exposure of clinical dose in pregnant rat remains unclear. Results: The following study was to explore lipidomics and transcriptomics changes related to 2% sevoflurane exposure for 6h in the developing brain of newborn offspring rats. UPLC/TOF-MS(Ultra Performance Liquid Chromatography/Time-Of-Flight Mass Spectrometry) and RNA-seq analysis was used to acquire metabolomics and transcriptomics profiles. We used RNA sequencing (RNA-seq) to analyze the expression of the coding and non-coding transcripts in neural cells of cerebral cortex. No significant differences in arterial oxygen tension (PaO2), arterial carbon dioxide tension (PaCO2), arterial blood gas were found between groups. RSDs(Relative Standard Deviation) of retention times were < 1.53%, and RSDs of peak areas ranged from 2.13% to 8.51%. BPC profiles showed no differences between groups. We evaluated the Partial Least Square-Discriminant Analysis (PLS-DA) model: in negative ion mode: R2X, over 70%: R2Y, over 93%: Q2 (cum), over 80%; Cell apoptosis was not remarkably enhanced by TUNEL and HE staining in sevoflurane exposure in comparison to control group(P>0.05). Glycerophospholipid and sphingolipid metabolism disturbance might have adverse influence on neurodevelopment in offspring. The expression of mRNAs (Vcan gene, related to neuronal development, function, and repair) of sevoflurane group were significantly increased in the differential genes by qRT-PCR verification. Conclusions: glycerophospholipid and sphingolipid metabolism homeostasis may be potential therapeutic approaches against inhalational anesthetics-induced neurodegenerative disorders. Meanwhile, sevoflurane induced Vcan changes, which indicate some lipidomics and transcriptomics changes was happened even if neural cell apoptosis was not significantly changed in usual clinical dose of sevoflurane exposure.
Motivational factors of pro-environmental behaviors among information technology professionals
Authors: Ojo Adedapo Oluwaseyi
Published: July 2021

Following research on the significance of employees’ behaviors in a firm’s environmental initiatives, this study explores the motivational factors that influence information technology (IT) professionals’ pro-environmental behaviors (PEBs). Based on the self-determination theory (SDT), autonomous and controlled motivations were posited as determinants of PEBs, and the green human resource management (GHRM) literature was integrated to examine the direct and indirect effects of GHRM practices. The hypothesized model was tested using data collected from 333 IT professionals in Malaysia. The results supported the view that autonomous motivation and GHRM practices have significant effects on PEBs. Furthermore, GHRM was a significant moderator of the effects of autonomous motivation on PEBs. On the contrary, the hypotheses that controlled motivation had a constraining effect, and GHRM has a moderating effect on PEBs were not supported. The present findings demonstrate that IT professionals’ PEBs are associated with environmental practices based on interest and value. Thus, this study extends the SDT by incorporating GHRM literature to deepen the understanding of the motivational factors of PEBs among a sample of IT professionals.
Modeling the Determinant of Time to Age at First Marriage among Women in Ethiopia using Cox models with mixed effects
Authors: Gobena Molalign Gualu , Berhan Yebelay Berelle
Published: July 2021

Background
Time to age at first marriage of women is the duration of time until the age at which they started living with their first partner. Time to age at first marriage is widely considered a proxy indicator for the age at which women begin to be exposed to the risks inherent in sexual activity. The purpose is to model the determinant of time to age at first marriage among women in Ethiopia using Cox models with mixed effects.
Methods
The 2016 EDHS sample was selected using a two-stage cluster design. The data set in this study were obtained from the Demography and Health survey conducted in Ethiopia in 2016. In this study, we used Cox models with mixed effects.
Results
Of all 15,683 women aged 15–49, 11,405(72.72%) were married and the median & mean age at first marriage for women living in Ethiopia were 17 years and 18 years respectively.
Conclusions
Based on the AIC criterion Cox frailty survival model (log-normal frailty distribution) was selected among Cox models with mixed effects as a better fit for the dataset. Analyzing based on the selected model showed that residence of women, educational level of women, head occupation, work status of women & head educational level were the most significant factors and religion of women, access to media of women & wealth index of a household were not significant factors at 5% level of significance. The clustering effect was significant and hence there was heterogeneity among the regions on age at first marriage.
New Wind-Wave Climate Records in the Western Mediterranean Sea
Authors: AMAROUCHE Khalid , Bingölbali Bilal , Akpinar Adem
Published: July 2021

This study presents a detailed analysis of changes in wind and wave climate in the Western Mediterranean Sea (WMed), based on 41 years of accurate wind and wave hindcasts. The purpose of this research is to assess the magnitude of recent changes in wave climate and to locate the coastal areas most affected by these changes. Starting from the Theil-Sen slope estimator and the Mann Kendall test, trends in mean and Max significant wave heights (SWH) and wind speed (WS) are analyzed simultaneously on seasonal and annual scales. Thus, the new wave records observed since 2010 have been located spatially and temporally using a simple spatial analysis method, while the increases in maximum wave heights over the last decade have been estimated and mapped. This work was motivated by evidence pointed out by several authors concerning the influence of global climate change on the local climate in the Mediterranean Sea and by the increase in the number and intensity of wave storm events over recent years. Several exceptional storms have recently been observed along the Mediterranean coasts, including storm Adrian in 2018 and storm Gloria in 2020, which resulted in enormous damage along the French and Spanish coasts. The results of the present study reflect a worrying situation in a large part of the WMed coasts. Most of the WMed basin experiences a significant increasing trend in the annual Max of SWH and WS with evident inter-seasonal variability that underlines the importance of multi-scale analysis to assess wind and wave trends. Since 2013, about half of the WMed coastline has experienced records in wave climate, not recorded at least since 1979, and several areas have experienced three successive records. Several WMed coasts are experiencing a worrying evolution of the wave climate, which requires a serious mobilization to prevent probable catastrophic wave storms and ensure sustainable and economic development.
Surgical Options for Localized Renal Cell Carcinoma, A Retrospective Clinical Study Based on Tumor Size
Authors: Li Jianyue , Li Xiang , Jiang Ziyu , Hu Canhong , Liu Jingbing , Liu Baorui , Huo Jiege
Published: July 2021

PurposeAlthough many studies have explored the options of radical nephrectomy (RN) and nephron sparing surgery (NSS) for localized renal cell carcinoma (RCC), the answer to this question remains unclear. This study aims to compare the long-term prognostic differences between RN and NSS among different sizes of localized RCC.MethodsThis study retrospectively included 80,439 T1-T4 N0 M0 patients who underwent RN or NSS based on the Surveillance, Epidemiology, and End Results database. We calculated the 10-year overall survival (OS) and cancer specific survival of patients with RCC. We also evaluated the risk of cardiovascular death in patients using competing risk models for RN and NSS.ResultsOur analysis showed that patients who underwent NSS had a more prolonged OS of 5 and 10 years when the tumor size was less than 8.5cm and 7.2cm. Compared to RN, NSS does not appear to improve OS in large (> 7.2cm) RCC patients. And stratified analysis showed that NSS for RCC less than 9.2cm may be more likely to benefit from long-term OS in younger patients (<60 years), while RCC above 7.3cm may be more suitable for RN in older patients (>=60 years). The gender-stratified results suggested male and female patients may be more suitable for NSS for RCC below 6.4 and 7.7cm, respectively. Besides, competing risk models showed patients receiving RN have higher cumulative cardiovascular mortality.Conclusions﻿For large RCC, NSS may be very carefully selected unless there are clear indications such as isolated congenital kidney and bilateral kidney cancer.
Is bone health of young atopic dermatitis patients a significant healthcare problem?
Authors: Kim Sooyoung , Choi Jimi , Cho Moon Kyun , Kim Nam Hoon , Kim Sin Gon , Kim Kyeong Jin
Published: July 2021

Background Atopic dermatitis (AD) incidence has increased over the past decades, especially among young adults. However, their bone health has not been clearly elucidated with discordant results. Objective We aimed to investigate the bone mineral density (BMD) measured by double energy X-ray absorptiometry and Z-score at the lumbar spine, femur neck, and total femur to evaluate the risk of osteoporosis in men aged <50 years and premenopausal women with AD.Methods The Korea National Health and Nutrition Examination Survey 2007-2009 data were used in this case-control cohort study. We included young AD patients (aged 19≤ and <50 years) diagnosed by a doctor and compared these patients with 1:5 propensity score weighting controls by age, sex, body mass index (BMI), vitamin D level, and alcohol/smoking status. Results We analyzed 311 (weighted n=817,014) AD patients and 1,555 (weighted n=4,155,855) controls. BMD at the lumbar spine was significantly lower in the male AD group than in the male control group (mean ± SE, 0.989 ± 0.002 vs. 0.954 ± 0.016, P = 0.03) while BMDs at the femur neck and total femur were comparable. For women, BMDs at the three sites were not significantly different between the AD and control groups. Low bone mass (defined by a Z-score of ≤2.0) was not significantly different between the AD and control groups in both sexes. Conclusions Bone health, especially BMD and Z-score, in young AD patients were comparable with those without AD. AD was not a risk factor for low BMD.
A Case of Primary CNS Embryonal Rhabdomyosarcoma with PAX3-NCOA2 Fusion and Systematic Meta-Review
Authors: Tanaka Ryuma , Inoue Kyohei , Yamada Yuji , Yoshida Masanori , Shima Haruko , Ito Jumpei , Okita Hajime , Miwa Tomoru , Kato Motohiro , Shimada Hiroyuki
Published: July 2021

Purpose: Primary central nervous system (CNS) rhabdomyosarcomais a rare mesenchymal tumor predominantly seen in children and associated with a poor outcome. We report a case of primary CNS rhabdomyosarcoma with PAX3-NCOA2 fusion and presenta systematic meta-review of primary CNS rhabdomyosarcoma to characterize this rare tumor.Methods: We present the case of a 6-year-old boy with primary CNS rhabdomyosarcoma in the posterior fossa. In a systematic meta-review, we compare the demographic data of primary CNS rhabdomyosarcoma with data of rhabdomyosarcoma at all sites from the SEER database and analyze clinical factors associated with survival outcome.Results: Our patient underwent gross total resectionand receivedvincristine, actinomycin-D, cyclophosphamide with early introduction of concurrent focal radiation and remained alive with no evidence of disease for 2 years after the end of therapy. Histopathological review revealed embryonal-type rhabdomyosarcoma, and whole-transcriptome analysis revealed PAX3 (EX6)-NCOA2 (EX12) fusion. In all, 77 cases of primary CNS rhabdomyosarcoma were identified through the meta-review. The demographic data of primary CNS rhabdomyosarcoma were similar to dataof rhabdomyosarcoma at all sites. Overall and event-free survival outcomes were available for 64 and 56 patients, respectively, with a 3-year OS of 29.5%and a 3-year EFS of 26.2%. The group that received trimodal treatment exhibited better survival outcomes, with a 3-year OS of 57.4%and a 3-year EFS of 46.3%.Conclusions: Primary CNS rhabdomyosarcoma shares common histological, molecular, and demographic features with non-CNS rhabdomyosarcoma. A trimodal treatment approach with early introduction of radiation therapy may result in favorable survival outcomes.
A Feedback-based Print Quality Improving Strategy for FDM 3D Printing: An Optimal Design Approach
Authors: Tamir Tariku Sinshaw , Xiong Gang , Fang Qihang , Dong Xisong , Shen Zhen , Wang Fei-Yue
Published: July 2021

Fused deposition modelling (FDM) 3D printing, as a supporting technology in social manufacturing and cloud manufacturing, is a rapidly growing technology in the era of industry 4.0. It produces objects with the layer-by-layer material accumulation technique. However, qualitative uncertainties are the common challenges yet. In order to assure print quality, studying the error causing parameters and minimizing their effects is important. This paper presents a feedback-based error compensation strategy, which integrates fuzzy inference system and grey wolf optimization algorithm. The objectives are twofold. First, the possible errors in FDM 3D printing are discussed in detail and optimal error causing parameters are obtained in percentage. This is used to understand the effects of the printing errors in every phase of the 3D printing process. From the nine optimization configuration trials used, Config-6 that has 100 number of iterations and 60 wolves is selected due to its higher convergence speed and best fitness value. The integral absolute error (IAE) is used as an objective function and the global minimum is achieved in the iteration interval [86, 100]. The outputs of this optimization problem is used to achieve the next objective. Second, a closed-loop quality monitoring approach comprising of inner-loops and an outer-loop is utilized. The three inner-loops are used to monitor the errors during pre-printing, printing, and post-printing, respectively. The outer-loop, on the other hand, is responsible for monitoring the aggregated errors in all the three 3D printing phases. The error compensation system simulation in Matlab is run for 10 seconds, and the results show that the "normal" range deformation factors are reached within less than 2 seconds for the inner-loops, whereas the outer-loop deformation factor is achieved within 7 seconds. The responses are within the acceptable time range.
Quality of Indonesia’s Domestic Institutions and Export Performance in the Era of Global Value Chains
Authors: Bustaman Arief , Indiastuti Rina , Budiono B , Anas Titik
Published: July 2021

The focus of this research is on analysing the effects of institutional quality and trade agreements on Indonesia bilateral trade in four commodity groups in the era of global value chains (GVSs). Employing a panel data gravity model of Indonesian export of four commodities to Indonesia’s 18 trading partners from 2000 to 2018, and estimating the Feasible Generalized Least Squares (FGLS) and the Poisson Pseudo Maximum Likelihood Method (PPML), the results of this study find that institutional quality plays a different role in explaining Indonesia’s export performance of those four commodities, despite the fact that institutions contribute positively. Regarding raw material and capital goods export, trading partner institutions are significant factors for Indonesian export of the two commodities. On two commodities that are relevant to Indonesia participation in the global value chain, exported intermediates and consumer goods, we find that although both domestic institutions and trading partner institutions are significant to Indonesian export, but we argue that domestic institutions contribute more. This study also reveals that through tariff reductions, Indonesian trade agreements are significant regarding export of intermediate and consumer goods, but less so for raw material and capital goods.
Spontaneous Parasitic myoma with the omental vessel: A Case report and literature review
Authors: Sunder Amala , Varghese bessy , bahzad noora , darwish basma
Published: July 2021

Aim: The study is the Case Report of spontaneous parasitic myoma with omental vessel, and the management at Bahrain Defense Force Hospital. Case Report: A 35years old female was diagnosed, almost 20 cm, sub serous myoma with the pedicle of 2cm from the fundus of the uterus. There was a feeding vessel from the omentum. She underwent myomectomy after the resection of pedicle and omental vessel .Post-operative period was uneventful. Conclusion: Parasitic myoma is the type of subserous uterine myoma. Generally surgical management is required for the relief of symptoms and to avoid encroachment of nearby abdominal or pelvic structures which in turn leads to further complications.
STUDY ON STRUCTURAL-ACOUSTIC CHARACTERISTICS OF CYLINDRICAL SHELL BASED ON WAVENUMBER SPECTRUM ANALYSIS METHOD
Authors:   College of Naval Architecture and Ocean Engineering, Naval University of Engineering, Wuhan 430033, China, Wenxi Liu , Huiren Guan , Qidou Zhou , Jingjun Lou
Published: July 2021

By the finite element method, the structural vibration response is calculated under the action of the axial exciting force and the moment with different distribution form, and then the transfer function of the mean square normal velocity is analyzed. The wavenumber spectrum analysis method is used to separate and quantify the shell vibration in the wavenumber domain, and then the relation between the structural vibration characteristics and the structural wavelength is summarized. It is concluded that the structural vibration and radiated noise can be reduced under the symmetric action of axial exciting force and the moment. Based on the above conclusion, a symmetrical thrust bearing supporting system is designed and the stiffness of the supporting structure in the axial direction is controlled by selecting suitable size of structural members, therefore, the structural vibration and radiated noise of the submarine is reduced significantly.
Research on Data Collection and Analysis of Second Hand House in China Based on Python
Authors: Wu Hejing , Cui Ran
Published: July 2021

With the rapid development of domestic Internet, more and more people choose housing leasing activities through the Internet, however, the existing housing rental information website the quantity many, but because of various advertising, information is scattered, so to HOME LINK sites, according to the position provided by the customer, accurate demand such as rent or house type, vertical search related data from the rental information website and in accordance with the provisions, the structure of the storage, rent information data to provide data for subsequent analysis. Bring users a faster experience. At the same time, we should add the reminding of the houses we are interested in and the reminding of price reduction. For the users who cannot look at their mobile phones all the time, timely reminding can help them avoid missing many desirable houses. This system is committed to solving the current people to rent a request for the search of detailed provide the keywords needed. To help make it easier for everyone who needs to rent. The system is mainly composed of data cleaning, data access, algorithm design and implementation, Python implementation of the front and back end of the system, data formatting and auxiliary decision.