bluuebunny/crossref_metadata_2025 huggingface dataset:
Avanços na Terapia Gênica para Doenças Neurológicas: Promessas e Desafios
Authors: Ottilo Cavassani Neto Rosiclerk , Romero Miguel da Costa Borges Cícero , De Oliveira Castro Adrian , Pereira Cordeiro Bruno , Tavares Hernandez Rodrigo , Luiz Ferreira Yuri , Martins dos Santos Neto Cleto , Sodré de Souza Gabriela , Estevam Fernandes Amaral Henrique , SAMARA DOS ANJOS MOURA LILLIAN , Ellen Souza dos Santos Lorena
Published: September 2024

Este artigo de revisão aborda os avanços recentes na terapia gênica para doenças neurológicas, destacando tanto as promessas quanto os desafios dessa abordagem inovadora. A introdução contextualiza a importância do tema, ressaltando o potencial transformador da terapia gênica para o tratamento de condições neurológicas graves e muitas vezes intratáveis, como as doenças neurodegenerativas, doenças raras e distúrbios psiquiátricos. A metodologia empregada incluiu uma busca abrangente nos principais bancos de dados científicos, utilizando termos específicos para identificar estudos relevantes que abordam diferentes aspectos da terapia gênica no contexto neurológico. Os resultados foram sintetizados em quatro tópicos principais: terapia gênica para doenças neurodegenerativas, para doenças neurológicas raras, para distúrbios psiquiátricos e outros distúrbios neurológicos, e os desafios e limitações dessa abordagem terapêutica. Cada tópico destacou as descobertas mais significativas e as estratégias mais promissoras, como o uso de vetores lentivirais e adenoassociados, bem como a aplicação de técnicas de edição gênica, como CRISPR/Cas9. Na discussão, foram exploradas as implicações dessas descobertas, com ênfase na necessidade de superar barreiras técnicas, como a entrega eficaz de genes ao sistema nervoso central, e nas considerações éticas e econômicas associadas à implementação clínica dessas terapias. A conclusão reforça o potencial da terapia gênica para revolucionar o tratamento de doenças neurológicas, ao mesmo tempo em que reconhece os desafios que ainda precisam ser superados. Este estudo contribui para o campo ao oferecer uma visão abrangente dos avanços e das limitações atuais, fornecendo uma base sólida para futuras pesquisas.
CÂNCER GINECOLÓGICO: AVANÇOS EM DIAGNÓSTICO E TERAPÊUTICA PERSONALIZADA
Authors: Holanda Ribeiro Claudia , Luísa Andrade Brito Maria , Clara Pereira Prado Nunes Maria , Daltro de Castro Rego Barros Guilherme , Reis Santos Daniel , Rodrigues Moura Vytoria , Viana Leôncio Plínio , Fabiano Sousa Barreto Alex , Buzahr Sousa Fontes Yanna , Pires Firpo Dantas Lara , Moura Araújo Sâmia , Martins de Carvalho Felipe , Carvalhal de Oliveira Firpo Costa Gabriella , Barbosa Fiuza Campelo Bruna , Brito Pereira Lemes Anita
Published: September 2024

Introdução: Os cânceres ginecológicos, que incluem câncer de ovário, endométrio, colo do útero, vagina e vulva, representam um importante grupo de neoplasias malignas que afetam a saúde da mulher em todo o mundo. Entre esses, os cânceres de ovário, endométrio e colo do útero são os mais prevalentes, sendo responsáveis por uma elevada taxa de morbidade e mortalidade.
Metodologia: A metodologia desta revisão integrativa foi projetada para abranger uma ampla gama de estudos que abordam os avanços em diagnóstico e tratamento de cânceres ginecológicos, com ênfase em abordagens personalizadas. A revisão seguiu as diretrizes metodológicas recomendadas para revisões integrativas, permitindo a inclusão de estudos com diferentes abordagens metodológicas, incluindo estudos qualitativos, quantitativos, revisões sistemáticas, meta-análises e ensaios clínicos. Esta abordagem permitiu uma visão abrangente e multifacetada das questões em análise.
Resultado: Uma das principais inovações no diagnóstico do câncer de próstata é a utilização da ressonância magnética multiparamétrica (mpMRI), que permite uma visualização detalhada da próstata e das lesões suspeitas. Este método não invasivo tem mostrado melhorar significativamente a acurácia diagnóstica, reduzindo a necessidade de biópsias repetidas e aumentando a detecção de tumores clinicamente significativos.
Conclusão: No campo do diagnóstico, a introdução de tecnologias avançadas de imagem e biomarcadores moleculares tem revolucionado a detecção e o estadiamento dos cânceres ginecológicos. A ressonância magnética (RM) e a tomografia por emissão de pósitrons (PET-CT) são cada vez mais utilizadas para proporcionar uma avaliação detalhada da extensão da doença, especialmente em cânceres de ovário e endométrio.
Gestão e Reabilitação de Lesões Musculoesqueléticas: Abordagens Contemporâneas
Authors: Cailany Prudencio Aliani Santos Carneiro Luan , Carvalho Levi Franco Anderson , Soares Araújo Raul , Mendes Maranhão Matheus , Barros Meireles Felipe
Published: September 2024

As lesões musculoesqueléticas são uma das principais causas de dor crônica e incapacidade física em todo o mundo, afetando milhões de pessoas de diferentes faixas etárias e contextos ocupacionais. Com o aumento da expectativa de vida e a maior demanda por qualidade de vida, a gestão e reabilitação dessas lesões se tornam cada vez mais relevantes na prática clínica. Nos últimos anos, novas abordagens contemporâneas têm sido desenvolvidas, incorporando avanços tecnológicos, como a realidade virtual, robótica, e terapias biofísicas, além de uma maior ênfase na abordagem multidisciplinar. Essas estratégias visam não apenas a recuperação funcional, mas também a redução de complicações e a melhoria da qualidade de vida dos pacientes. Este estudo tem como objetivo realizar uma revisão sistemática da literatura para avaliar a eficácia das abordagens contemporâneas na gestão e reabilitação de lesões musculoesqueléticas. Os resultados da revisão indicam que as abordagens contemporâneas na gestão e reabilitação de lesões musculoesqueléticas, incluindo intervenções tecnológicas e multidisciplinares, estão associadas a melhores desfechos clínicos. Houve uma redução significativa nas complicações pós-tratamento, uma recuperação funcional mais rápida e melhorias na qualidade de vida dos pacientes. Além disso, essas abordagens demonstraram ser custo-efetivas em diversos contextos clínicos. No entanto, a heterogeneidade dos métodos e desfechos avaliados limitou a capacidade de realizar uma meta-análise quantitativa. A revisão sistemática conclui que as abordagens contemporâneas para a gestão e reabilitação de lesões musculoesqueléticas são eficazes na melhoria dos desfechos clínicos, contribuindo para a redução de complicações e para uma recuperação mais rápida e eficiente dos pacientes. A integração de novas tecnologias e a colaboração multidisciplinar são elementos chave para o sucesso dessas intervenções. No entanto, são necessários mais estudos de alta qualidade para padronizar essas abordagens e expandir sua aplicabilidade em diferentes contextos clínicos.
Burnout em profissionais de saúde: uma revisão das definições, fatores de risco e estratégias de prevenção
Authors: Eduarda Pereira dos Santos Maria , De Queiroz Moura Rezende Valéria , De Abreu Candido de Souza Paloma , Cristina Silva Fabiano Amanda , De Brito Meneguelo Bianca , De Sousa Miranda Lucas , Katharina Peixoto da Silva Maria , Nunes de Melo Zilma , Victória Oliveira Bispo Jamilly , Carrara Folly Valente Jaqueline , Xavier de Paula Thaís , Bassani Deconto Aline , Nery Rebeca
Published: September 2024

Este artigo revisa a literatura sobre a Síndrome de Burnout em profissionais de saúde, abordando suas definições, fatores de risco e estratégias de prevenção. A Síndrome de Burnout é uma condição psicológica caracterizada por exaustão emocional, despersonalização e redução da realização pessoal, frequentemente associada ao ambiente de trabalho estressante dos profissionais da saúde. A revisão analisou diversos estudos que identificaram fatores de risco, incluindo carga de trabalho elevada, falta de suporte social, e a pressão emocional constante presente nas atividades diárias. Além disso, foram discutidas estratégias de prevenção, como a promoção de um ambiente de trabalho saudável, programas de apoio psicológico, e a importância de práticas de autocuidado. Os resultados indicaram que a implementação de intervenções direcionadas pode reduzir significativamente a incidência da Síndrome de Burnout, melhorando a qualidade de vida dos profissionais e a qualidade do atendimento prestado aos pacientes.
A EFICÁCIA DO USO DO CANABIDIOL NO TRATAMENTO DE MULHERES COM ENDOMETRIOSE: UMA REVISÃO SISTEMÁTICA.
Authors: Marques Bezerra Emanuel Felipe , Torres de Quintella Cavalcanti Ingrid Alves , Jucá Mario Jorge
Published: September 2024

INTRODUÇÃO: A endometriose caracteriza-se pela presença de tecido endometrial ectópico, ou seja,  células endometriais que fizeram o caminho inverso da menstruação natural, fixam-se nas estruturas da cavidade pélvica e/ou abdominal, e que por uma fisiopatologia ainda, em parte, desconhecida, passam a proliferar-se ocasionando lesões, que evoluirão para a endometriose propriamente dita acarretando a dor pélvica, infertilidade, entre outros sintomas. Geralmente o diagnóstico é mais tardio e o seu tratamento disponível resume-se a analgésicos, mudança de estilo de vida e até cirurgias, e xxx anos para até então, surge o Canabidiol, uma das substâncias da Cannabis sativa, como uma alternativa que tem se mostrado eficaz para integrar essa terapêutica álgica. OBJETIVO: O objetivo deste estudo é avaliar a efetividade do uso canabidiol em pacientes diagnosticadas com endometriose para o tratamento da dor. METODOLOGIA: Trata-se de uma revisão de escopo  de artigos que deveriam estar em inglês, portugues ou espanhol, publicados entre janeiro de 2019 e julho de 2024 e incorporados a uma das seis bases de dados utilizadas: Pubmed, Science Direct, Scielo, BVS, Wiley online library e BASE. Nessas bases foram utilizadas as palavras-chave “Canabidiol”, “Endometriose” e “Dor pélvica”, entre elas estava o operador booleano “AND”. RESULTADOS: Foram encontrados 91 artigos, dos quais quatro eram repetições e outros 79 foram rejeitados por não se encaixarem nos critérios de inclusão ou por coincidirem com algum critério de exclusão, apenas oito artigos foram selecionados. CONCLUSÃO: O canabidiol mostrou-se efetivo para o uso terapêutico em dor pélvica nas pacientes com  endometriose.
Editorial: Teaching and Learning for Sustainable Futures
Authors: McDonald Jared , Bernard Eleanor , Simpson Zachary
Published: September 2024

In this editorial, the guest editors and SOTL4theSouth conference organisers reflect on the significance of the theme of the conference and special issue, and present an overview of the papers included.
Navigating Mergers and Demergers in the Technology Sector: A Guide to Managing Change and Integration
Authors: Kumar Kodyvaur Krishna Murthy  , Prof.(Dr.) Arpit Jain  , Er. Om Goel
Published: September 2024

In the dynamic landscape of the technology sector, mergers and demergers have become pivotal events that significantly impact organizational structures, strategic directions, and operational efficiencies. This guide delves into the intricacies of navigating these complex transitions, focusing on managing change and ensuring effective integration. The technology sector's rapid evolution necessitates a nuanced understanding of how mergers and demergers can be strategically orchestrated to achieve desired outcomes while mitigating potential risks.
The process of merging or demerging involves numerous challenges, including cultural integration, alignment of business processes, and harmonization of technological systems. Successful management of these transitions requires a comprehensive strategy that encompasses clear communication, meticulous planning, and robust execution. This guide outlines key strategies for managing change during these transformative periods, emphasizing the importance of leadership, stakeholder engagement, and the adoption of best practices.
Pengaruh Dosis Phospor Dan Pupuk Cair Pada Tanaman Bunga Kol (Brassica Oleracea Var. Botrytis L)
Authors: Kurnia Dewi Tyas Soemarah , Supriyadi Teguh , Suprapti Endang , Budiyono Agus , Mardhika Sari Siti
Published: September 2024

Cauliflower is a vegetable that has commercial value and excellent prospects for public consumption. According to the Central Statistics Agency of the Republic of Indonesia, cauliflower production has decreased from 2019 to 2021, therefore it is necessary to improve maintenance, one of which is by providing Phosphorus fertilizer to increase productivity. This will increase the rate of photosynthesis to produce high productivity and the correct dose of liquid organic fertilizer (POC) to maximize growth in the vegetative and generative phases thereby increasing the yield of cauliflower plants. This research aims to determine the effect of giving various doses of Phosphorus and POC fertilizers on the growth and yield of cauliflower plants. The research was carried out in the village, Girilayu, Matesih, Karanganyar from February to May 2024. Using the Complete Randomized Block Design (RAKL) method consisting of 2 treatment factors and 3 replications. The first factor is the dosage of Phosphorus (P) fertilizer P1: 100 kg/ha, P2: 150 kg/ha, P3: 200 kg/ha. The second factor is the dose of POC (C), C1: 4 cc/L, C2: 8 cc/L, C3: 12 cc/L. The results research showed (1) Giving various doses of Phospor fertilizer had a very real effect on fresh stover, dry stover, plant diameter, plant weight per plant, and crop weight per plot. However, it does not have a real effect on plant height and number of leaves. (2) Giving various doses of POC had a very real influence on fresh stover, dry stover, plant diameter, and plant weight per plant had a real influence on crop weight per plot and had no real influence on plant height and number of leaves. (3) The interaction between treatments had a very real influence on fresh stover, dry stover, and plant weight per plant, and had no real influence on plant height, number of leaves, plant diameter, and weight per plant plot. (4) The highest results were obtained in the branch pruning treatment 3 weeks after planting with an NPK fertilizer dose of 200 kg/ha, namely a plant weight of 11,997.4 grams per plot (26,644 kg/ha).
Paradigma dan Tantangan Pendidikan Seni dalam Mengintegrasikan Akhlaq, Teknologi, dan Multikulturalisme
Authors: Handayani Lucy , Hartono  , Saearani Muhammad Fazli Taib Bin
Published: September 2024

Art education faces various paradigms and challenges in the modern era, where the integration of moral values, technological development, and multiculturalism is increasingly important. This study aims to examine the challenges and opportunities in integrating moral values, technology, and multiculturalism into art education. This research uses Creswell's naturalistic qualitative method. The results of this study include: First, moral values encompassing ethics, morality, and character are outlined as fundamental foundations in shaping students' personalities. Second, rapid technological development provides both opportunities and challenges in adapting innovative and interactive art learning methods. Third, multiculturalism and cultural diversity are important elements in enriching artistic perspectives and promoting inclusivity. Through this approach, it is hoped that art education can produce creative, critical, and character-driven individuals who are ready to face the ever-changing global dynamics.
Refleksi Budaya Etnis Tionghoa dalam Kesenian Barongsai di Kota Singkawang
Authors: Putra Zakarias Aria Widyatama , Wulanda Gigih Alfajar Novra
Published: September 2024

The lion dance is a form of ethnic Chinese culture with a beautiful variety of motion and visual ornaments.  The purpose of this research is to serve as a reminder of cultural preservation and inheritance. The primary reflection resources paired with Feldman's art criticism method include a historical overview, performance dynamics, ritual/celebration procedures, and cultural heritage. This study also provides a glimpse into and description of ethnic Chinese's effort to express cultural arts following a time of prejudice. The dissection is carried out utilising descriptive qualitative methodologies, with data collected through participant observation, in-depth interviews, and documentation. Triangulation of sources with ethnomusicologists validates the data analysed using an inter-academic model. Cultural reflection produced by Barongsai arts for ethnic Chinese includes reminders and awareness of evaluative materials related to the struggle for discrimination in the historical context, entertainment and sports functions in the context of performance dynamics, meanings and symbols of happy and sad expressions in the context of ritual / celebration processes, and sorting out incoming outside cultures for the younger generation in the context of cultura. It is critical and beneficial that the findings of this study serve as a vehicle and platform for future attempts to maintain and enhance the Barongsai art form. In addition, there needs to be support between elements of the ethnic Chinese community and the government so that the art of Barongsai can be preserved and developed in the future.
Boardgame Sebagai Media Edukasi Bagi Orang Tua Terhadap Perkembangan Motorik Anak Penyandang Autisme di Kota Palembang
Authors: Asnia  , Halim Bobby , Patriansah Mukhsin
Published: September 2024

Autism is a developmental disorder that affects communication, social interaction, behavior and learning ability. Autism is caused by a combination of genetic and environmental factors. Autism symptoms generally begin to appear at the age of 1.5 to 3 years, with obvious physical and mental decline compared to individuals who do not have autism. In this case, the main problem is parental guidance which is very influential, such as the lack of knowledge or understanding of parents about how to improve the development or ability of their children. This has a very bad impact, because it only makes autistic children feel not understood and accepted as they are. To overcome the problems in the developmental disorders of autistic children, a solution was found, namely the therapy given to each child with autism will indeed be more effective if it involves the active role of parents. Therefore, it is necessary to design a Visual Communication Social Campaign on the Role of Parents towards the Motoric Development of Children with Autism in Palembang City. In the process of designing media, the design thinking method is used which includes empathize, define, ideate, prototype, and test. With this design, it is expected to be an educational platform, especially the role of parents that can improve the motoric development of children with autism in Palembang City.
Vascularized Interpositional Connective Tissue Graft: An Alternative in Esthetically Demanding Regions. A Case Report and Literature Review
Authors: Wiedemann Thomas G
Published: September 2024

Objective: This case report aims to showcase the utilization of a vascularized interpositional pedicle connective tissue graft and a Maryland bridge as an alternative treatment to bone graft and implant placement. Clinical considerations: The case report illustrated the success of a well-thought-out alternative treatment plan to implant placement, achieving esthetically pleasing and functional results. Conclusion: The vascularized interpositional pedicle connective tissue graft can serve as a less invasive alternative that achieves an esthetically pleasing outcome.
The Impact of Ethnocentrism and Cultural Values on Domestic Tourism
Authors: Sharma Rashmini , Singh Gurmeet , Pratt Stephen
Published: September 2024

While domestic tourism significantly outpaces international tourism, a notable research scarcity is dedicated to understanding local travel behaviors. This study addresses this gap by proposing and empirically testing a novel conceptual model that integrates the Theory of Planned Behavior
(TPB), Hofstede’s cultural dimensions theory, and tourism ethnocentrism to assess the willingness of individuals to visit local destinations. Data collected from an online survey of 641 respondents indicate that tourism ethnocentrism positively influences attitude and willingness to
visit local destinations. Additionally, attitude, subjective norms, and perceived behavioral control were found to positively affect the willingness to visit local destinations, which, in turn, positively influenced local travel behavior. Interestingly, the study also revealed that uncertainty
avoidance amplified, while individualism attenuated, the relationship between TPB and tourism ethnocentrism. These findings offer insights for policymakers and local governments, businesses in the tourism industry, local communities, and residents. It also assists in achieving the United Nations
Sustainable Development Goals, specifically SDG 8: Decent Work and Economic Growth, SDG 10: Reduced Inequalities, SDG 11: Sustainable Cities and Communities, and SDG Responsible Consumption and Production.
The Significance of Hypermagnesian Clinopyroxene in the Yanisvaara Ultrabasic Complex, Kola Peninsula, Russia
Authors: Barkov Andrei Y. , Nikiforov Andrey A. , Martin Robert F. , Korolyuk Vladimir N. , Silyanov Sergey A.
Published: September 2024

Two generations of hypermagnesian clinopyroxene [92 < Mg# < 98] are found in the Yanisvaara ultrabasic complex in the northwestern Lapland–Belomorian Belt, Kola Peninsula, Russia. Grains of a first generation (Wo47.3–50.7En46.5–49.4Fs2.5–3.5), 0.2–0.4 mm across, are attributed to a reaction in which tremolite + clinopyroxene replaced orthopyroxene. The second generation generally attains even more strongly magnesian compositions (Wo46.5–50.9En47.5–50.8Fs1.0–3.2). It is sporadically developed as submicrometric rim- or veinlet-like grains associated with tremolite and domains of fresh olivine with Mg# in the range 80.5–82.5 to 87.7–88.0. The later generation of clinopyroxene crystallized at elevated values of fO2 under closed-system autometasomatic conditions rather than during regional metamorphism. The compositions attained in three representative samples are highly magnesian, but characteristically poor in Cr compared to primary clinopyroxene. Compositions of the accompanying silicate, oxide, and sulfide minerals are provided. A novel Ni-Mn oxyspinel may be related to hausmannite. Yanisvaara and coeval subvolcanic komatiitic complexes are inferred to have degassed, which promoted the rapid rise in fO2 and indirectly promoted the buildup of Mg in the late clinopyroxene.
Implementasi Manajemen Proyek Penguatan Profil Pelajar Pancasila di SMPN Kabupaten Magetan
Authors: Wahyudi Rahmad , Hariyati Nunuk , Mariana Neni
Published: September 2024

Pendidikan di Indonesia yang terus berkembang, ditandai dengan perubahan kurikulum yang terus menerus dan tantangan yang ditimbulkan oleh pandemi COVID sembilan belas. Dengan latar belakang tersebut, penelitian ini bertujuan untuk mengetahui implementasi Kurikulum Merdeka Belajar, khususnya dengan fokus pada proyek penguatan profil siswa Pancasila di dua sekolah terpilih di Kabupaten Magetan. Metodologi yang digunakan adalah pendekatan kualitatif fenomenologi dengan desain penelitian multi lokasi. Metode pengumpulan data meliputi wawancara mendalam, observasi, dan analisis dokumen, yang dilakukan pada bulan Maret hingga Mei dua ribu dua puluh empat. Hasil penelitian mengungkapkan perencanaan yang komprehensif, pengorganisasian yang efektif, keberhasilan pelaksanaan, dan evaluasi proyek secara menyeluruh. Khususnya, proyek ini telah menghasilkan peningkatan yang signifikan dalam pemahaman siswa tentang nilai-nilai Pancasila dan pengembangan karakter. Kesimpulan yang diambil dari studi ini menggarisbawahi pentingnya perencanaan yang cermat, organisasi yang kuat, strategi implementasi yang inovatif, dan evaluasi berkala dalam mencapai tujuan inisiatif pendidikan karakter dalam kerangka Merdeka Belajar.
Economics of Palliative Care & Evaluation of Alternate Mode through Integrated Palliative Care Services by an Inclusive Cost Effective Model
Authors: Sandhya S , Manasaa G K , Kumaran G Senthil
Published: September 2024

The necessity for equitable access to palliative care in Tamil Nadu, where approximately 7 lakh patients require such services annually, remains pressing. Despite the availability of advanced medical technologies and highly qualified specialists, only a small fraction of patients receive the required palliative care due to financial and systemic barriers. This article explores the economic implications of palliative care, highlighting the exorbitant costs associated with allopathic treatments and the ethical challenges faced by clinicians. It also underscores the financial viability of integrating homoeopathic remedies into palliative care, given their significantly lower costs and fewer side effects. A comprehensive approach to palliative care that includes both conventional and homoeopathic medicine is proposed to improve accessibility and affordability. The article recommends a multidisciplinary strategy, emphasizing partnerships between public and private sectors, expanded health insurance coverage, community and family support, and enhanced training and education for healthcare professionals. Additionally, it calls for increased public awareness and ongoing research to demonstrate the economic and clinical benefits of integrated palliative care models. The integration of homoeopathy is particularly emphasized as a cost-effective, patient-centered approach that can improve quality of life for patients. The article concludes with a call for systemic changes to implement inclusive, high-quality palliative care services throughout Tamil Nadu.
Relationship between Attitude Toward Aging, Health Literacy, and Utilization of Healthcare Services among Older Adults in Suburban Areas in Iligan City
Authors: Abordo Ian , Belle Sumugat Donna , Salvador Raymond , L. Garay Jan Niña , D. Permites Michelle , S. Soronio Kent
Published: September 2024

Background and Aim Health literacy and attitudes towards aging have become increasingly important problems, especially as they relate to health care. This study focused on exploring the relationship between attitudes toward aging, health literacy, and utilization of healthcare services among older adults.  Methods Using quantitative, descriptive-correlational design, data were collected from 150 older adults through structured questionnaires.  Results Older adults agreed that the services are being provided adequately. The study found a positive correlation between having adequate knowledge to manage health and the accessibility of healthcare services, and it also indicated that providing adequate information to the public can increase their knowledge about health services and facilities provided. Providing adequate information to the public can increase their knowledge about the health services and facilities provided.  Conclusion These results highlight the need for intervention that increases the utilization of healthcare services among older adults. The overall attitude towards aging is positive. High levels of health literacy are essential to enhance their ability to access and improve utilization of healthcare services. A positive attitude toward aging correlates to the accessibility of healthcare highlighting the importance of considering attitudes in the healthcare concept. There was a significant relationship between attitude toward aging, health literacy, and utilization of healthcare services among older adults.
Close Encounters of Wide Binaries Induced by the Galactic Tide: Implications for Stellar Mergers and Gravitational-wave Sources
Authors: Stegmann Jakob , Vigna-Gómez Alejandro , Rantala Antti , Wagg Tom , Zwick Lorenz , Renzo Mathieu , van Son Lieke A. C. , de Mink Selma E. , White Simon D. M.
Published: September 2024

A substantial fraction of stars can be found in wide binaries with projected separations between ∼102 and 105 au. In the standard lore of binary physics, these would evolve as effectively single stars that remotely orbit one another on stationary Keplerian ellipses. However, embedded in their Galactic environment, the low binding energy of wide binaries makes them exceptionally prone to perturbations from the gravitational potential of the Milky Way and encounters with passing stars. Employing a fully relativistic N-body integration scheme, we study the impact of these perturbations on the orbital evolution of wide binaries along their trajectory through the Milky Way. Our analysis reveals that the torques exerted by the Galaxy can cause large-amplitude oscillations of the binary eccentricity to 1 − e ≲ 10−8. As a consequence, the wide binary members pass close to each other at periapsis, which, depending on the type of binary, potentially leads to a mass transfer or collision of stars or to an inspiral and subsequent merger of compact remnants due to gravitational-wave radiation. Based on a simulation of 105 wide binaries across the Galactic field, we find that this mechanism could significantly contribute to the rate of stellar collisions and binary black hole mergers as inferred from observations of luminous red novae and gravitational-wave events by LIGO/Virgo/Kagra. We conclude that the dynamics of wide binaries, despite their large mean separation, can give rise to extreme interactions between stars and compact remnants.
The Trojan-like Colors of Low-perihelion Kuiper Belt Objects
Authors: Belyakov Matthew , Brown Michael E. , Al-Kibbi Alya
Published: September 2024

An important testable prediction of dynamical instability models for the early evolution of the solar system is that Jupiter Trojans share a source population with the Kuiper Belt. Concrete evidence of this prediction remains elusive, as Kuiper Belt objects (KBOs) and Jupiter Trojans appear to have different surface compositions. We address the long-standing question of Trojan origin by finding a dynamical subpopulation in the Kuiper Belt with Trojan-like colors. Combining existing photometric data with our own surveys on Keck I and Palomar P200, we find that the low-perihelion (q < 30 au, a > 30 au) component of the Kuiper Belt has colors that bifurcate similarly to the Jupiter Trojans, unlike Centaurs (a < 30 au), which have redder, Kuiper Belt-like colors. To connect the Jupiter Trojans to the Kuiper Belt, we test whether the distinct Trojan-like colors of low-perihelion KBOs result from surface processing or are sourced from a specific population in the Kuiper Belt. By simulating the evolution of the Canada–France Ecliptic Plane Survey synthetic population of KBOs for four billion years, we find that differences in heating timescales cannot result in a significant depletion of very red low-perihelion KBOs as compared to the Centaurs. We find that the neutrally colored scattered disk objects (e > 0.6 KBOs) contribute more to the low-perihelion KBO population than to Centaurs, resulting in their different colors.
Sea surface temperature differences between in situ and GHRSST (L4) records in a socio-ecological critical area of the northeastern Pacific Ocean May 2015 to July 2016
Authors: López-Ramírez Juan Alfredo , Morales-Zárate María Verónica , Rubio-Rodríguez Uriel , Salinas-Zavala César A. , Chávez-Juárez Florian
Published: September 2024

Using satellite sensor data for studying sea surface temperature (SST) provides advantages over in situ information, such as obtaining data from large areas and remote access regions in short periods. However, differences between the SST values recorded in situ and those by satellite sensors are due to the intrinsic nature of both methods and meteorological factors. The present study aims to search the difference between SST values from in situ and satellite sensor data of 1×1 km resolution (type L4) from the Group of High-Resolution Sea Surface Temperature (GHRSST) for an annual cycle in a socio-ecological critical area known as the Gulf of Ulloa (GU). The linear regression, linear spline regression, and logic models showed an overestimated SST by satellites compared to in situ data, particularly at temperatures below 20°C. The overestimation can be attributed to the oceanic-atmospheric variations, which are consequences of upwelling and the time lag between the data record morning by in situ and night by satellite sensors. This finding may be relevant in decision-making for marine resource management and conservation in the GU. The information may help to seek the sustainability of this social-environmental system.
Alleviative effects of combined topical melatonin and rutin on imiquimod-induced psoriasis mouse model
Authors: Khorsheed Shan Mohammed , Abu-Raghif Ahmed Rahma , Ridha-Salman Hayder
Published: September 2024

Background: Psoriasis is a longstanding autoimmune dermatosis with thickened, reddish-brown, and flaking skin lesions. Melatonin is an indolamine hormone exhibiting antioxidant, anti-inflammatory, and anti-proliferative actions. Rutin is a nutritional flavonoid possessing antioxidative, anti-inflammatory, and immunomodulatory properties.

Aim: To explore the potential anti-psoriatic activity of combined topical melatonin and rutin.

Methods: 70 albino mice were divided into 7 groups of 10 each. The impacts of clinical observation, histopathological examination, and biomarker analysis were estimated.

Results: Combined topical melatonin and rutin effectively diminished imiquimod-induced elevated PASI and Baker’s scores and corrected histopathological aberrations. Diminished inflammatory indicators like TNF-α and IL-17A, angiogenic elements like VEGF, oxidative elements like MDA, and proliferative elements like Ki-67 were also noted.

Conclusion: Combined topical melatonin and rutin have profound anti-psoriatic effects.
Assessing Competencies, Needs, and Satisfaction With the Transition From Pediatric to Adult Health Care in Rheumatology: Development and Validation of the Transition-KompAZ
Authors: Haney Henriette , Klotsche Jens , Niewerth Martina , Hansmann Sandra , Erbis Gabi , Reiser Christiane , Saur Sebastian Jonas , Hoff Paula , Seipelt Eva , Maier Anna , Schalm Susanne , Tatsis Stefanie , Foeldvari Ivan , Kötter Ina , Minden Kirsten
Published: September 2024

J Rheumatol 2024; doi:10.3899/jrheum.2024-0097

There were incorrect footnotes in Table 2. All instances of footnote "a" in the Possible Score Range column should be an asterisk. The correct footnote should be, "Only participants with ≤ 1 missing or * additional answer category (ie, "does not currently apply to me") per domain are included for the sum score of the corresponding scale." We apologize for this error. This correction applies only to the August 15 2024 First Release. The correct table appears in the print and online issues.
Mutations de l’enseignement supérieur et internationalisation
Authors: Soulas Christine
Published: September 2024

Résumé Alors que l’un des objectifs des réformes de Bologne est de faciliter la mobilité étudiante, les obstacles restent nombreux pour l’étudiant qui souhaite poursuivre ses études dans une université après les avoir commencées dans un autre type d’établissement. Cependant, on assiste en France à l’émergence de programmes passerelles entre formations en deux ans et études universitaires. De tels programmes existent aux États-Unis depuis plusieurs décennies, notamment en Californie où les transferts entre community colleges et universités prennent une nouvelle importance. Cette étude compare les situations en France et en Californie : publics, motivations politiques et réactions des acteurs universitaires.
Interroger le médico-social
Authors: Guilhot Nicolas , Jaubert Guillaume
Published: September 2024

Ce chapitre dresse un panorama des pratiques d’évaluation dans le secteur médico-social en reprenant les quatre niveaux mentionnés par la loi 2002-2. Aux contradictions des catégorisations mises en œuvre dans l’évaluation des besoins répondent les polarisations d’une évaluation à dimension médicale pour les personnes âgées et à dimension biopsychosociale pour les personnes en situation de handicap. En matière d’évaluation des politiques publiques, les contraintes budgétaires ont entraîné le développement d’une conception de la performance qui a outillé une forme de « gouvernement à distance » et poussé à la rationalisation industrielle. Enfin, le déploiement de l’évaluation de la qualité des prestations des ESMS s’est fait en écho à celle des politiques publiques en mobilisant une conception de la performance pensée du point de vue de l’usager. La formalisation actuelle de l’évaluation de la qualité dans le secteur médico-social par la HAS la rapproche de la certification sanitaire. La multiplication des indicateurs fournit un instrument de concurrence par la comparaison qui se substitue à la fonction du prix dans un marché qui en est presque dépourvu.
Interroger le médico-social
Authors: Lenoir Stéphane
Published: September 2024

Dans le champ du handicap, le secteur médico-social fait l’objet de vives critiques notamment parce qu’il s’oppose au droit commun. En effet, il s’adresse à une population particulière, ce qui laisse entendre qu’elle serait une population à part. Néanmoins, aujourd’hui, des personnes handicapées ne pourront trouver les professionnels et les conditions d’accompagnement dont elles ont besoin que dans ce secteur dit médico-social. Ce chapitre montre qu’il est vain de chercher à opposer droit commun et droit médico-social. Il y a d’abord urgence à rendre notre société accessible à toutes et tous pour éviter les phénomènes de ségrégation, et concomitamment, à réinterroger les fonctions des établissements et services médico-sociaux. Dans le cas contraire, nous continuerons à observer des espaces sociaux dédiés à des personnes handicapées.
Introduction aux statistiques en sciences du langage
Authors: Olive Thierry
Published: September 2024

Résumé L’étude en temps réel de la production du langage écrit vise à décrire le fonctionnement cognitif des rédacteurs et la dynamique de la production écrite. Pour cela, l’activité d’écriture est enregistrée et diverses variables informant sur le processus d’écriture sont collectées et analysées. Ce chapitre présente un panorama des principales méthodes et techniques qui peuvent être utilisées pour, d’une part, étudier les processus cognitifs impliqués dans la production du langage écrit, du tracé de lettres à la production de textes et d’autre part pour analyser la dynamique du texte « en train de se faire » (la textualisation ; Cislaru et Olive, 2018).
Introduction aux statistiques en sciences du langage
Authors: Gilhodes Jean-Claude , Fabiani Elie , Longcamp Marieke , Velay Jean-Luc , Danna Jérémy
Published: September 2024

Résumé L’étude de la graphonomie (Graphonomics) dans le domaine du langage écrit est le pendant de l’étude de la parole dans le domaine du langage oral. Mais contrairement à la parole où le processus de production sonore caractérise la performance, la performance d’écriture s’étudie à partir de l’analyse conjointe du produit, c’est-à-dire de la trace écrite, et du processus, mouvement qui génère cette trace. Les tablettes graphiques, utilisées avec un ordinateur, ou les tablettes numériques, véritables ordinateurs portables sous forme d’écrans tactiles sans clavier, permettent de recueillir les coordonnées spatiales de la pointe du stylo, la pression exercée par la pointe du stylo sur la tablette, et l’inclinaison latérale et antéropostérieure du stylo. Grâce à l’enregistrement de ces variables toutes les 5 ou 10 ms (selon la fréquence d’acquisition de 200 ou 100 Hz, respectivement), il est possible de calculer des variables spatiales relatives à la trace écrite, ainsi que des variables temporelles, cinématiques et dynamiques relatives au mouvement d’écriture. Ce chapitre expose les problématiques relatives à l’utilisation des tablettes et décrit la manière d’acquérir et d’analyser l’ensemble des variables de l’écriture manuscrite grâce à un logiciel gratuit et en libre accès que nous avons développé.
Jurisprudences du secteur social et médico-social
Authors: Smallwood Olivier
Published: September 2024

Étude n˚ 6 : Les coopérations institutionnelles, l’exemple des GCSMS La mise en place d’un Groupement de coopération sociale ou médico-sociale est susceptible d’offrir aux établissements et organismes gestionnaires qui en sont membres de réelles opportunités, tant sur le terrain de la mutualisation de moyens permettant notamment la réalisation d’économies d’échelles, que sur celui de la valorisation de leurs complémentarités. Ce type de Groupement obéit néanmoins à un cadre juridique strictement défini par les textes législatifs et réglementaires en vigueur, qui doit être pris en considération par les futurs partenaires dès les premières réflexions intéressant la configuration de l’outil de coopération en cours de constitution. À défaut, les membres et le Groupement lui-même sont susceptibles de s’exposer à des risques juridiques, pouvant parfois donner lieu à des contentieux, et constituant en tout état de cause des obstacles à la réalisation des objectifs poursuivis.
Le moment européen
Authors: Bellamy Richard , Kröger Sandra , Crignon Philippe
Published: September 2024

On pourrait estimer que l’intégration différenciée, conformément à laquelle des États membres se retirent ou sont exclus de certaines politiques européennes pour des motifs de souveraineté ou de capacité, sape le fonctionnement de l’Union européenne en tant qu’elle serait ce que John Rawls a appelé un système équitable de coopération, fondé sur des normes d’impartialité et de réciprocité. Nous soutenons pourtant que différentes formes d’intégration différenciée sont compatibles soit avec une coopération équitable entre les États suivant le modèle du droit des peuples de Rawls, soit avec une coopération entre les citoyens suivant son modèle des deux principes de la justice domestique. Cependant, l’UE possède des caractères dérivés des deux formes, dans la mesure où elle est à la fois une Union internationale d’États et une Union supra- et transnationale de citoyens. Nous défendons la cohérence de cette combinaison et soutenons qu’une intégration différenciée peut apporter un mécanisme justifié qui garantit que l’équité entre les États reste compatible avec l’équité entre les citoyens à la fois dans chaque État et à l’échelle globale de l’Europe. Elle fournit au demeurant un modèle potentiel pour d’autres formes de coopération internationale.
Le moment européen
Authors: Spector Céline
Published: September 2024

Cette contribution entend revenir sur les arguments du discours conservateur et eurosceptique tenu par Viktor Orbán dans son allocution du 23 juillet 2023. Peut-on surmonter l’objection selon laquelle la démocratie trouve à s’exprimer de manière privilégiée — voire unique — au sein des États-nations ? Que répondre aux politiques qui soutiennent que la nation est la condition sine qua non de la démocratie, le seul lieu d’exercice possible des droits politiques, le terreau de la liberté, de l’égalité et de la fraternité ? N’a-t-on plus le choix qu’entre le Charybde de la mondialisation et le Scylla de la restauration de l’État-nation ? Il importe de déceler les sophismes du discours anti-Lumières. Tout en intégrant la religion dans un discours lyrique sur la « civilisation », les thèses souverainistes comme celles de Viktor Orbán reposent sur une réification du peuple souverain et sur une vision falsifiée de la démocratie moderne. Distinguer peuple et nation et accepter le double fondement de la démocratie – sur la souveraineté du peuple et les droits de l’homme – permet au contraire de suggérer qu’un peuple européen peut advenir, dans le contexte géopolitique actuel, sans mettre en péril les demoi nationaux.
Le Déméter 2019
Authors: Bellon-Maurel Véronique , Bournigal Jean-Marc , Lenain Roland
Published: September 2024

Si l’avènement du numérique et de la technologie dans l’agriculture ( AgTech ), souvent appelé la "quatrième révolution industrielle", offre de grandes perspectives de réponse aux nombreux défis sociétaux, économiques et environnementaux auxquels est confronté la production agricole, celui-ci présente également de nombreuses menaces et limites. Ce chapitre explore les différents leviers technologique et numérique pour une transition vers une agriculture durable tout en mettant en lumière les enjeux stratégiques que sont la gestion et le partage des données, la coopération entre agriculteurs et entreprises, la formation etc.
Le Déméter 2019
Authors: Canteneur Pauline
Published: September 2024

Responsable aux deux tiers de la production de fruits et légumes du territoire nord-américain, la Californie constitue l’État agricole le plus riche des États-Unis. Le  Golden State  est également le berceau de la Silicon Valley. Depuis l’époque des pionniers, la Californie accorde à l’innovation technologique une place centrale. Pourtant, l’industrie agricole californienne fait aujourd’hui face à de grandes crises. Elle doit, en effet, composer avec une main-d’œuvre de moins en moins disponible, ainsi qu’une pression croissante des gouvernements locaux et fédéraux en matière de préservation de l’environnement. Des technologies nouvelles et prometteuses à l’instar des logiciels d’analyse des données, développées sur le sol californien, laissent envisager la possibilité d’un nouvel eldorado.
Le Déméter 2019
Authors: Bonjean Alain P.
Published: September 2024

Parmi les nouvelles biotechnologies (NBT), l’édition de gènes représente, dans la continuité des techniques classiques de sélection, d’innovantes possibilités de création variétale précise, et ce, dans trois domaines : l’inactivation d’un gène, la modification d’un gène ou l’insertion d’un gène de manière ciblée. Ainsi, les NBT créent de la variabilité génétique, permettent de comprendre le déterminisme génétique, font gagner du temps et réduisent les coûts de fabrication d’une variété. Si de nombreux gouvernements ont adapté leurs législations à ces nouveaux enjeux, tel n’est pas le cas de l’Union européenne. Sauf à réviser et corriger son approche juridique actuelle des NBT, l’avenir de l’agriculture européenne pourrait être menacé.
Le Déméter 2019
Authors: Le Morvan Yves , Valluis Bernard
Published: September 2024

Au cœur de la construction européenne depuis ses origines, la politique agricole commune (PAC) est devenue plurielle du fait d’une grande hétérogénéité des situations nationales, générant de la complexité ainsi que des distorsions de concurrence. Dans une période marquée par des bouleversements géopolitiques et des échéances politiques souvent imprévisibles, à l’image du "Brexit" et des élections européennes, et alors que l’agriculture se doit de concilier de vastes et divers objectifs, comme ceux propres à l’environnement, au climat, à l’aménagement du territoire, à la chaîne alimentaire ou à la santé, cette contribution pose un regard prospectif sur la PAC et son devenir après 2020.
Le Déméter 2019
Authors: Renaud Bénédicte
Published: September 2024

Les coproduits de l’industrie agroalimentaire et leurs valorisations sont une réalité indissociable de la transformation agroalimentaire, et plus largement de la chaîne alimentaire. Ce gisement, estimé en France à 12,1 millions de tonnes de matière sèche, et sa valorisation (alimentation animale, cosmétique, agronomie, filière énergétique etc.) sont autant d’éléments contribuant à l’équilibre économique des filières. En s’appuyant sur l’enquête Réséda sur les gisements et valorisations des coproduits, cette contribution s’attache à montrer comment les coproduits s’inscrivent, en France, dans trois axes de développement : la bioéconomie, l’économie circulaire et la lutte contre le gaspillage alimentaire.