bluuebunny/crossref_metadata_2025 huggingface dataset:
30 años de Estudios de Filosofía
Authors: Arango Muñoz Santiago
Published: February 2020

La revista Estudios de Filosofía nació en 1990 en lo que era el Departamento de Filosofía y que luego se transformó en el Instituto de Filosofía de la Universidad de Antioquia. Su fundador y primer director fue el profesor Jairo Alarcón Arteaga. Además, el primer comité editorial estaba conformado por Jorge Antonio Mejía Escobar, Javier Domínguez Hernández, Jorge Montoya Peláez y Gustavo Valencia Restrepo. En el número 10 de la revista se creó el primer comité científico, que en ese momento se llamó “comité internacional”, y estaba compuesto originalmente por Miguel Giusti, José María González, Pablo de Greiff, Axel Honneth y Friedrich Kambartel.
La verdad del cuerpo. Heidegger y la ambigüedad de lo corporal
Authors: Xolocotzi Yáñez Ángel
Published: February 2020

Ampliamente conocidos son los señalamientos realizados en Ser y tiempo por Martin Heidegger en torno al contraste entre la corporalidad pensada modernamente con base en una mezcla de cuerpo-alma, de raigambre cartesiana, y la corporalidad existenciaria a partir del Ser-en-el-mundo del Dasein. Después de ello y con pocas alusiones en algunas de sus lecciones, la tematización mayor en torno al cuerpo se remonta a los Seminarios de Zollikon. El presente artículo busca nuevas vías de tematización a partir de lo que Heidegger piensa como ambigüedad de la verdad en las diversas versiones de la conferencia “De la esencia de la verdad. La verdad del cuerpo dejaría ver al cuerpo en su errar como Körper y, por otro lado, en tanto misterio como Leib. Tal perspectiva permite una comprensión no unilateral del cuerpo y a la vez abre las posibilidades para pensarlo desde el Ser-en-el-mundo, tal como Heidegger había anunciado en diversos momentos de su obra.
¿Existencia auténtica en la época de la técnica?
Authors: Gómez Herrera Claudia Marcela
Published: February 2020

En sus escritos tempranos Heidegger plantea que la existencia fluctúa entre un modo de ser auténtico e inauténtico. Una de las diferencias que se establece entre estos modos de la existencia consiste en la manera en la que se experimenta el tiempo en uno y otro. El presente artículo pretende proponer un enlace entre las nociones de temporalidad heideggeriana y, a la luz de dicho enlace, establecer los rasgos que la existencia auténtica podría adquirir en la época de la técnica. Para lograr este propósito, retomaré una cita de Borges con el fin de esbozar cómo podría pensarse una relación entre las dos nociones de temporalidad. Una vez esbozada la relación, se revisarán algunas de las tesis heideggerianas sobre la época de la técnica que nos ofrezcan las herramientas para reflexionar acerca de los matices que adopta la existencia auténtica en nuestra época. En ese sentido, sugiero que la serenidad puede concebirse como la manera en la que la existencia auténtica actúa. La serenidad no es pasividad del hombre frente a la técnica, sino un modo de responder al acontecer del ser, una manera genuina de actuar acorde a la época.
Wendland, J., Merwin, C. y Hadjioannou, C. (Eds.). (2018). Heidegger on technology. New York: Routledge
Authors: Moreno Omar Camilo
Published: February 2020

En muchos sentidos diferentes, la crisis mundial actual (los enfrentamientos en medio oriente, la inestabilidad política y social de Latinoamérica, las múltiples migraciones, el resurgimiento de los fascismos en los países europeos, el cambio climático, entre otros) no es propiamente un síntoma del fracaso del proyecto ilustrado occidental y de sus instituciones. Desde una perspectiva heideggeriana, se trata de un problema ontológico, de una crisis en el acercamiento técnico al mundo que se hace manifiesta gracias a las fuertes tensiones internas del ideal del progreso. Sin embargo, no podemos hablar propiamente de una crisis en la tecnología. Basta ver los impresionantes desarrollos de los últimos 20 años para comprobar que estamos en la época más radicalmente técnica que ha existido jamás. Desde los computadores personales hasta las modificaciones en el genoma humano son muestras y garantías del efectivo desarrollo y de las grandes promesas del desarrollo científico e industrial. Entonces cobra sentido la pregunta ¿qué significa preguntar por la esencia de la técnica, es decir, del acercamiento técnico al mundo?, ¿cuál es el problema con la tecnología?
Aproximación a los usos de la información de costos como estrategia para la toma de decisiones de los hospitales y clínicas de Rionegro y La Ceja
Authors: Tobón-Tobón Yesica , Gómez-Carvajal Santiago , Henao-Betancur Juan Fernando
Published: February 2020

El sector salud en Colombia presenta ciertas problemáticas que dificultan, en algunos casos, los procesos de toma de decisiones, por esto es necesario contar con sistemas de información que den soporte a las decisiones en busca de beneficios para la entidad y, por ende, garantizar el bienestar de la sociedad. Es allí donde la contabilidad de costos juega un papel importante pues tiene como propósito ser un instrumento de apoyo en la planeación y toma de decisiones a través de la información que proporciona. Todo esto denota la importancia de realizar una investigación de carácter cualitativo que permita determinar el uso que se le da a la información obtenida a través de los sistemas de costos en los hospitales y clínicas de Rionegro y La Ceja, a través de la aplicación de entrevistas a las personas relacionadas con esta información. Con el trabajo de campo, se concluye principalmente que la información se usa esencialmente para decisiones de contratación y tarifas, pero no se logra tener un alto grado de confianza por las variaciones en el proceso de recolección y procesamiento de esta información, especialmente en el sector público.
Preliminares de pensamiento sistémico sobre la relación contabilidad y organización
Authors: Ospina-Zapata Carlos Mario
Published: February 2020

Se presenta una reflexión crítica respecto del pensamiento tradicional con el que se aborda el sentido de la contabilidad y la organización. Dicha crítica coloca en discusión el arquetipo del pensamiento científico de corte analítico y positivista respecto del pensamiento sistémico. Con algunas nociones tales como “emergencia”, “relación sistema – entorno”, “complejidad” propias del enfoque de sistemas se instalan algunas hipótesis que permiten una comprensión de la relación contabilidad y organización. En especial se concluye que la contabilidad no es solo información para la toma de decisiones y que las comunicaciones que provee son utilizadas por actores diversos de la organización para otorgarle sentido a sus prácticas. Dicha utilización no opera como herramienta dirigida a, sino como racionalidad y esquema de distinción.
It All Happens at Once: Understanding Electoral Behaviour in Second-Order Elections
Authors: Schmitt Hermann , Sanz Alberto , Braun Daniela , Teperoglou Eftichia
Published: February 2020

The second-order election (SOE) model as originally formulated by Reif and Schmitt (1980) suggests that, relative to the preceding first-order election result, turnout is lower in SOEs, government and big parties lose, and small and ideologically extreme parties win. These regularities are not static but dynamic and related to the first-order electoral cycle. These predictions of the SOE model have often been tested using aggregate data. The fact that they are based on individual-level hypotheses has received less attention. The main aim of this article is to restate the micro-level hypotheses for the SOE model and run a rigorous test for the 2004 and 2014 European elections. Using data from the European Election Studies voter surveys, our analysis reveals signs of sincere, but also strategic abstentions in European Parliament elections. Both strategic and sincere motivations are also leading to SOE defection. It all happens at once.
THE HIERARCHY OF PROFESSIONAL WELL-BEING FACTORS IN DIFFERENT PROFESSIONAL GROUPS
Authors: Pakhol B. E.
Published: February 2020

The article studies peculiarities of the hierarchy and the structure of professional well-being factors characteristic for the representatives of different professional groups. Based on the empirical data obtained for the representatives of different professions, and based on the performed correlation analysis between the factors of the 6-factor model of professional well-being (the mixed professional sample) and indicators of professional well-being in different professional groups, it was found that the hierarchy (strength of correlations) of the professional well-being factors is significantly different for different professions, in particular, for architects, police inspectors, managers, sales managers, sale representatives (medical salespersons), police investigators, economists and programmers. Significant differences in the hierarchy of professional well-being factors between some professional groups were determined, first and foremost, for the following factors: “professional motivation”, “flow at work” and “evaluation of professionalism and professional identity”. There were no significant differences for the factors such as “job satisfaction”, “satisfaction with the made professional choice” and “satisfaction with work processes and content” for different professional groups. The performed analysis of the research results suggests that some statistically significant differences in the hierarchy of professional well-being factors can be found out between “self-sufficient” (architects, police investigators, managers) and “dependent” professions, such as police inspectors or sale representatives (medical salespersons). The invariance of the factor structure for professional well-being and the proven significant differences in the factor hierarchy for different professional groups testify to the possibility to develop the author’s model of professional well-being for representatives of different professions.
PSYCHOLOGICAL MEANS FOR WOMEN’S SHYNESS OVERCOMING
Authors: Kovalenko A. B. , Gryshuk E. Yu. , Rohal N. I.
Published: February 2020

The article analyses psychological factors of women’s shyness and ways to overcome it. The research on shyness of 18–22-year old women has help us determine its causes; the most significant of them are insufficient self-confidence and fears of negative assessments. Women with heavy shyness are prone to solitude, have problems with their identification in the family; they evaluate, feel and experience acutely their own imperfections and take guidance from opinions of others and social acceptance; they expect usually criticism and negative assessments from other people, etc. To overcome women’s shyness, the training program was developed that covered the following aspects: the notion of shyness and the causes of its emergence, the peculiarities of shyness influence on women’s life, the methods to reduce shyness, the negative factors affecting shyness. The proposed training consisted of four units: the first block was aimed at familiarizing of its participants with the notion of shyness, its factors and possible ways of overcoming; the participants’ expectations from the training and discussion of the psychological peculiarities of shyness in women’s life were collected during the second block; the third one was aimed at development of knowledge and skills for shy behaviour regulation; the final survey, feedback and training conclusion were done during the fourth block. After the training program approbation, the participating women changed significantly to the way of improvement a number of their own assessments: shyness, introversion / extraversion, attitude to shyness as a desirable trait. Women re-evaluated their ability to overcome shyness and became more willing to work on themselves and apply efforts for changes. The following personal traits of women were also improved: openness, independence and courage, autonomy, social activity and social adaptability; such socializing institutions as school, informal organizations and the Internet have become more important for them.
PECULIARITIES OF THE ATTITUDE TO WORK OF YOUTH WITH DIFFERENT ECONOMIC STATUSES
Authors: Ozerova V. A.
Published: February 2020

The article analyses the study results concerning socio-psychological peculiarities of the attitudes to work of youth with different economic status. The socio-psychological model of the “attitude to work” concept is presented as a multilevel system that acts as part of the system of human relations and is closely linked to the formation of a person. This concept consists of three main components: motivationally-semantic, emotionally-axiological and behavioral. Attention should be paid to the importance of the problem of economic states of young people, which affects their attitudes to the labor.
Basing on the socio-psychological model of attitude to work, we selected ten key indicators that reflect important social and psychological characteristics of young people’s attitudes to labor according to the three-component model of attitudes to work. The motivational-semantic component is represented by the following indicators: striving for external rewards; internalization of the purpose of social and professional activities; orientation to power; process orientation. The emotional-value component includes such features as satisfaction with relations with colleagues; satisfaction with management personnel relations; satisfaction with job conditions; sense of success in professional work. The behavioral component includes such indicators as readiness for energy expenditure and a socially active strategy of problem solving. These indicators have been empirically investigated for the groups of youth with low, average and high economic statuses. The performed correlative analysis has shown the existing significant links between these indicators and economic statuses of youth. The one-factor dispersion analysis has shown that young people of all three groups have statistical differences for all components, but the greatest differences are between young people with high and low economic statuses.
Las villas gallegas: concepto y realidad / Galician small towns: concept and reality
Authors: Barreiro Quintáns Daniel , López Rodríguez Ramón , Lois González Rubén Camilo
Published: February 2020

La heterogeneidad de las villas, las peculiaridades del territorio gallego y sus cambios recientes y la falta de definiciones que las engloben a todas dificultan su identificación. Sus características a nivel demográfico, económico, morfológico y funcional se han de comparar con las definiciones existentes con el fin de debatir sobre su significado y proponer una solución a las deficiencias identificadas.L’hétérogénéité des petites villes, les particularités du territoire galicien et le manque de définitions qui les englobent, rendent leur identification difficile. Leurs caractéristiques démographiques, économiques, morphologiques et fonctionnelles doivent être comparées aux définitions existantes afin de débattre de son sens et de proposer une solution aux carences identifiées.The heterogeneity of small towns, the peculiarities of the Galician territory and its recent changes as well as the lack of definitions that encompass all of them make difficult their identification. Their demographic, economic, morphological and functional characteristics must be compared with the existing definitions in order to debate its meaning and propose a solution to the identified deficiencies.
Evolución de la Universidad en la Sociedad del Aprendizaje y la Enseñanza. El valor de las competencias en el desarrollo profesional y personal
Authors: Álvarez-Arregui Emilio
Published: February 2020

Sociedad, Educación y Universidad han estado interrelacionadas en base a los condicionantes económicos, sociales, estructurales, tecnológicos, políticos, jurídicos y funcionales concurrentes en cada momento histórico. Las decisiones adoptadas en este ecosistema han sido, son y serán controvertidas porque no son neutras ideológicamente lo que ha acabado determinando culturas organizativas y funcionales ligadas a los sistemas de poder y conocimiento vigentes que se legitiman en las áreas geográficas en las que se integran. En este artículo hacemos un recorrido por el pasado, presente y futuro de la universidad desde diferentes miradas desde las que se avala la necesidad de evolución de estas organizaciones desde un enfoque sistémico y multidisciplinar lo que requiere alinear el aprendizaje, la enseñanza, la formación, la investigación, la gestión, el talento y el compromiso desde un paradigma integrador que nos permita generar las innovaciones necesarias para adaptarnos y proyectarnos en un entorno que no tiene antecedentes pretéritos y del que desconocemos su evolución. En consecuencia, es preciso que la universidad asuma el valor real de las competencias para que las personas concurrentes en estas instituciones aprendan y enseñen a aprender y emprender si quieren adaptarse a un contexto de cambio rápido y complejo.
La formación en competencias como estrategia para mejorar la dirección pública
Authors: Castaño Ana María , García-Izquierdo Antonio
Published: February 2020

La reciente crisis económica ha acrecentado la preocupación por un servicio público eficiente, haciendo necesario mejorar las prácticas de gestión para afrontar los desafíos organizacionales emergentes como la diversidad, la ética y la digitalización, entre otros. Para ello, un elemento crucial es la formación para el desarrollo de competencias directivas que mediante la modalidad blended learning conforma una estrategia para mejorar la dirección pública. Esta modalidad permite integrar formación presencial y a distancia mediante las plataformas MOOC reduciendo costes y flexibilizando tiempos. El objetivo de este trabajo es elaborar una propuesta fundamentada desde el enfoque de aprender haciendo para desarrollar programas formativos para el personal directivo. Primero, hemos analizado las limitaciones de los procesos de recursos humanos, proponiendo los modelos de competencias como un marco adecuado para este fin. Posteriormente, tras la detección de necesidades formativas hemos propuesto un programa que incluye estrategias formativas y evaluativas para las denominadas competencias duras y blandas. Finalmente, hemos discutido las implicaciones del programa formativo en el contexto actual de los constantes cambios tecnológicos y sociales.
CLOUD ERP SOFTWARE SUITABILITY ANALYSIS FOR AUTOMOTIVE COMPONENTS SMALL AND MEDIUM INDUSTRY USING ANALYTICAL HIERARCHY PROCESS
Authors: Saputra Mas'ud Adhi , Prabowo Yunita , Witjaksono Wahjoe
Published: February 2020

Small and Medium Industry (SMI) is a form of business activity that is not only limited to the business of buying and selling, but there are activities of production process, simple organizational management, and cooperation with other parties. SMI has limited in terms of cost and management of human resources in improving company performance. With the tight competition of the automotive component industry, there needs a strategy to manage SMIs effectively and efficiently. Information Technology (IT) plays a very significant role in actualizing that. Many of automotive component SMIs in Indonesia still run the companies in conventional ways. Though of course, IT is able to make company management better, through the use of Enterprise Resource Planning (ERP) software. The problem statement in this study is the selection of cloud-based ERP software that is suitable for the automotive component SMI. With the cloud-based ERP, automotive component SMIs have a centralized system. To reduce implementation costs, recommended ERP software is open source. In determining the priority of cloud-based ERP software criteria using the Analytical Hierarchy Process (AHP) method. AHP is used to compare three candidates for cloud-based ERP software, namely Odoo, Idempiere and xTuple. The results obtained that Odoo ranks highest compared to two other software candidates. This shows that Odoo is considered to be able to meet the needs of automotive component SMIs for the needs of cloud-based ERP software.
KOMUNIKASI VIRTUAL GAME ONLINE DEFENCE OF THE ANCIENT–DOTA 2 PADA KOMUNITAS RAZER GAMING DEPOK VIRTUAL COMMUNICATION IN THE DEFENCE OF THE ANCIENT–DOTA 2 ONLINE GAME AT THE RAZER GAMING DEPOK COMMUNITY
Authors: Teguhta Teguhta , Dunan Amri
Published: February 2020

Abstract In the era of the industrial revolution 4.0, virtual communication tends to be preferred over face-to-face communication among teenagers. Virtual communication is usually carried out in virtual communities that share a hobby like online game players.interviews and observations method were used on data collection.  Data presentation, categorization, and data reduction are carried out at the data analysis stage. Data triangulation is done to conclude. The findings of this study are the virtual communication all channels patterns apply in Depok Razer Gaming Community. Virtual communication often used about the selection of strategies in the online game Dota 2.Keywords: virtual communication, online game  Abstrak Kalangan remaja cenderung lebih menyukai komunikasi virtual dibandingkan dengan komunikasi tatap muka pada era revolusi industri 4.0 saat  ini. Komunitas virtual yang memiliki kesamaan hobi seperti para pemain game online biasanya melakukan komunikasi virtual. Tujuan penelitian ini untuk mengidentifikasi pola komunikasi virtual dalam game online Defence of the Ancient–Dota 2 dalam Komunitas Razer Gaming Depok. Penelitian ini menggunakan.  pendekatan deskriptif kualitatif . Pengumpulan data  di lapangan menggunakan metode wawancara dan pengamatan. Pada tahapan analisis data peneliti melakukan penyajian data, pengkategorisasian, dan reduksi data. Peneliti melakukan triangulasi data yang ada untuk penarikan kesimpulan. Penelitian ini menemukan bahwa  pola komunikasi virtual yang berlangsung di Komunitas Razer Gaming Depok adalah pola komunikasi semua saluran (all channel). Komunikasi virtual sering membahas tentang pemilihan strategi dalam game online Dota 2. Kata Kunci : komunikasi virtual,  game online
NARROWING THE DIGITAL DIVIDE OF PEOPLE WITH DISABILITIES TO ENSURE THE TECHNOLOGY AND SOCIAL INCLUSION
Authors: Wahab Riva'atul Adaniah
Published: February 2020

The digital divide for disabilities is a barrier to information acquisition, which is a basic need for self-development, social environment, and participation in national development. However, the implementation of Indonesian government policies and programs still has not shown the expected results. From the access aspect, some disabilities cannot obtain ICT infrastructures. Moreover, the challenge in accessing the government web is due to the inconsistent implementation of policies. From the ability aspect, the stigma of discrimination that is still developing in educational institutions and the private sector are an integral obstacle to encourage productivity, absorption in the workforce, or open employment opportunities. Thus, the target of fulfilling the proportion of people with disabilities in employment cannot be achieved. Those require collaboration and cooperation between the central government sector, local and central government, central government and private, and educational institutions to fulfill their rights and be able to compete in local, national, and international scale. Furthermore, a joint commitment is required in the form of policy or affirmative policy accompanied by supervision and periodic evaluation with clear standards that encourage the fulfillment of the rights of people with disabilities to ICT.
Concepto de la calidad de la educación superior virtual desde el análisis del discurso: el caso de las políticas en Colombia
Authors: Sanmiguel Ruiz Carolina , Alemán de la Garza Lorena Yadira , Gómez Zermeño Marcela Georgina
Published: February 2020

Este artículo de investigación expone los resultados de un estudio de caso sobre las políticas públicas en Colombia y su relación con la conceptualización de la calidad en la educación superior virtual. A través del análisis del discurso de un corpus seleccionado de documentos oficiales, el estudio busca responder a la pregunta: ¿qué ha significado la calidad de la educación superior virtual para el Ministerio de Educación Nacional de Colombia? En el análisis de cómo se pueden fortalecer los procesos de conceptualización, gestión y evaluación de la calidad de la educación superior virtual en el país, los resultados revelan que, si bien el concepto de calidad de la educación superior virtual no existe de forma explícita en las políticas públicas, sí se perciben ciertos significados implícitos del concepto, así como algunos mecanismos de evaluación y gestión de la calidad, entendida esta a partir de la acreditación y la certificación, el desarrollo tecnológico y los contenidos educativos.
El papel de las sociedades científicas y la academia en la actualización permanente del plan de beneficios en el sistema de seguridad social en Colombia
Authors: Gaitán Hernando
Published: February 2020

El plan de beneficios ha sido definido como un “conjunto de actividades, procedimientos, suministros y reconocimientos que se brinda a las personas, con el propósito de mantener o recuperar la salud y evitar el menoscabo de su capacidad económica derivada de la incapacidad temporal por enfermedad general, maternidad y la incapacidad, discapacidad o invalidez derivada de los riesgos de accidentes de trabajo y enfermedad profesional”.1En Colombia la ley 100 creó inicialmente tres planes de beneficios: el plan de atención básica (PAB), el plan obligatorio de salud contributivo (POS) y el plan obligatorio de salud subsidiado (POSS), diferentes en su origen y en los servicios que proporcionan a la población beneficiaria. La sentencia T 760 de 2008 de la Corte Constitucional ordenó, entre otros aspectos, los relacionados con el plan de beneficios: “(i) adoptar medidas para eliminar la incertidumbre acerca del contenido de los planes de beneficios y lograr la actualización periódica de los mismos; (ii) unificar los planes de beneficios (POS y POSS), primero en el caso de los niños y, luego, progresivamente en el caso de los adultos, teniendo en cuenta su adecuada financiación”.2
Prolapso de trompa uterina: reporte de casos y revisión de la literatura
Authors: Niño-Hernández Lucía Mercedes , Redondo-Bermúdez César , Redondo de Oro Katherine , Marrugo-Grace Olivia , Arteta-Acosta Cindy , Alcalá-Cerra Gabriel
Published: February 2020

Objetivo: el prolapso de la trompa uterina constituye una complicación quirúrgica poco frecuente y habitualmente ocurre de manera secundaria a la histerectomía vaginal. Dicha patología constituye un reto diagnóstico dado el espectro de lesiones benignas y malignas a nivel del cuello uterino. El presente reporte de casos tiene como objetivo revisar la literatura respecto a la etiología, el diagnóstico y el tratamiento de la entidad.Materiales y métodos: se presentan tres casos de prolapso de trompa uterina, así como una revisión de la literatura, a través de una búsqueda electrónica en las bases de datos Medline vía PubMed, Hinari, SciELO y EMBASE, para recopilar información publicada, tanto en inglés como en español, de los últimos 5 años.Conclusión: el prolapso de trompa uterina poshisterectomía, ya sea vaginal o abdominal, es una complicación quirúrgica anómala. El diagnóstico definitivo se realiza por medio del estudio histopatológico, al evidenciar tejido tubárico asociado a un infiltrado inflamatorio. Para su tratamiento, diferentes técnicas quirúrgicas han sido propuestas con el objetivo de resecar, ya sea parcial o totalmente, la trompa prolapsada con reparo de la apertura vaginal.
THE EFFICACY OF RECOMBINANT INTERLEUKIN-1Β IN SURGICAL TREATMENT OF ACUTE ULCERATIVE GASTRODUODENAL BLEEDINGS
Authors: Allahverdiyev Vidadi Agababa
Published: February 2020

There was reported the results of the use of recombinant interleukin-1β in basic conservative measures in the surgical treatment of acute gastroduodenal ulcer bleeding. Gastric ulcer were in 20 patients, duodenal ulcer in 84 patients and combined ulcers in 16 patients. According to А.А. Шалимов hospitalized patients with mild blood loss were 27, moderate degree - 62 and severe degree - 31 patients. According to J. Forrest, 29 showed active bleeding (F Ia, F Ib), in 67 - unstable hemostasis (F IIa, F IIb, F IIc) and in 24 - F III. Within the framework of differentiated individual-active tactics, patients were operated in emergency (21), urgent (38), delayed (35), and 26 people underwent early planned operations. Patients in the main group (63) after the operation, was included recombinant interleukin-1β to the basic therapeutic measures additionally, taking into account the degree of blood loss and immune disorders. Patients of comparison group (57) before and after surgery received standard basic therapy without immunocorrection. In a comparative aspect, it has been proved that in postoperative period on the background of standard conservative measures, the use of recombinant interleukin-1β positively influences elimination of the secondary immunodeficiency and cytokine imbalance significantly improves the results of surgical treatment.
CHANGES THE CYTOKINE PROFILE AND CALCIUM-REGULATING HORMONES IN RHEUMATOID ARTHRITIS
Authors: Huseynova Asmaya Saftar
Published: February 2020

The aim was to study the level of some cytokines (İL-2, İL-6, İL-8 TNFα) and calcium regulating hormones (calcitonin, parathyroid hormone, 25 (OH) D) in the blood of patients with rheumatoid arthritis (RA) depending on rheumatoid factor (RF) and the assessment of the role of the revealed violations in the pathogenesis of bone loss in this pathology. For this purpose, 74 patients with RA (59 women, 15 men) aged from 27 to 71 were examined. On the basis of RF in the blood serum, the patients were divided into 2 groups: seronegative and seropositive RA. The control group included 16 healthy individuals (13 women, 3 men). The results obtained that the serological variant of RA affects the serum levels of proinflammatory cytokines and calcium-regulating hormones: more pronounced changes were found in seropositive RA. The high production of IL-2, IL-6, IL-8, TNF-α and parathyroid hormone detected in both groups of patients undoubtedly contributes to the mechanisms of bone loss in RA. In both groups we detected hypovitaminosis D. This results recommended to use this vitamin in the complex treatment of RA.
ROLE OF ERYTHROCYTES IN MECHANISMS OF NONSPECIFIC PROTECTION OF BLOOD IN INFECTION CAUSED BY THE FUNGUS OF GENUS PAECILOMYCES
Authors: Akhunov V. M. , Sizova Zh. M. , Galgóczi László , Akhunova A. M. , Lavrentyeva T. P.
Published: February 2020

Paecilomyces variotii is a commonly occurring species in air and food, and it is also associated with many types of human infections. Tissue forms of the fungus Paecilomyces variotii or their cytoskeletons were revealed in the cytoplasm of erythrocytes in patients with allergy and bronchial asthma in paecilomycosis. Our study was aimed at investigating the role of red blood cells in the mechanisms of the nonspecific protection of the host in conditions of chronic persistent infection of the blood with the fungus of the genus Paecilomyces. We examined a total of eighty-four 16-to-72-year-old patients (39 men and 45 women) presenting with activation of paecilomyces infection in blood. We used laboratory, biochemical, allergic-and-immunological and microbiological methods of study. Fungal cultures were identified phenotypically and by means of phylogenetic analysis.Our findings are suggestive of a new type of the oxygen-dependent mechanism of cytotoxicity of erythrocytes, which is caused by permanent formation of reactive oxygen species as a result of non-enzymatic oxidation of haemoglobin to methaemoglobin. The resulting superoxide anion radical (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (OH-) exhibit a powerful bactericidal action which is, probably, activated when the fungal cells are captured and immersed in the erythrocyte cytoplasm or in a closed cavity formed by RBCs around large fungal cells. In conditions of chronic blood infection with tissue forms of fungi of the genus Paecilomyces oxygen-dependent cytotoxicity of erythrocytes is the main mechanism of readjustment of blood from the infectious agent of Paecilomycosis.
EVALUATION OF ANTI-CANDIDA ACTIVITY OF METABOLITES OF ENTEROCOCCAL CLINICAL ISOLATES
Authors: Alexandrova Natalya A. , Zaslavskaya Maya I. , Soloveva Irina V. , Tochilina Anna G. , Belova Irina V.
Published: February 2020

When studying the effect of the metabolic products of clinical isolates of enterococci on the viability of Candida albicans, it was found that metabolites of all tested strains of Enterococcus faecium, E. faecalis had a fungistatic effect. At the same time a reliable fungicidal effect is a strain-specific feature. It is better to use the method of delayed antagonism on double-layer agar to assess the antifungal effect of enterococcal metabolism products.
Software complex for assessment and rehabilitation of motor disorders in patients with ischemic stroke
Authors: Tolmachev I. V. , Alifirova V. M. , Kаzakov S. D. , Koroleva E. S.
Published: February 2020

Objective. Development of a specialized software complex that creates a controlled virtual environment as well as to capture and calculate the movement data in the process of rehabilitation.

Materials and methods. To evaluate the impact of visual stimuli created using the augmented reality system on the motor function, a software was developed that visualizes data via augmented reality glasses and processes data obtained from motion capture sensors. The study was conducted at the Department of Neurology and Neurosurgery and the Department of Medical and Biological Cybernetics of Siberian State Medical University in 2018–2019. The sample included 59 patients with acute ischemic cerebral stroke in the middle cerebral artery. The course of motor rehabilitation using augmented reality technology was ten days. The duration of one training session was 60 minutes.

Results. Motor neurorehabilitation of patients with paresis of the upper extremities using augmented reality makes it possible to improve motor skills. Analysis of the accuracy of movements showed a significant increase in the value of the spectral criterion with an increase in the number of trainings, which indicates a decrease in the number of unnecessary movements during the main task. A significant increase in the number of completed movements with each subsequent training was revealed. This indicates a rise in the speed of the task over the course of rehabilitation, as well as reduction of the rest period between the attempts performed during one training session.

Conclusion. The developed specialized software recreates a controlled virtual environment with the ability to register the parameters of human movement. The method was used for rehabilitation of motor disorders in patients with ischemic stroke of the brain and paresis of the upper extremities. The results of the study revealed a significant increase in the accuracy of movements, and a rise in endurance, which indicates the effectiveness of the approach in motor neurorehabilitation.
Incidence rate of anxiety and personality disorders and their interrelationship in senior-year students of the medical university
Authors: Ukraintsev I. I. , Schastnyy E. D. , Bokhan N. A.
Published: February 2020

Objective: to study the incidence rate of personality and anxiety disorders and their interrelationship in seniors of the medical university.

Materials and methods. The screening study for detection of personality and anxiety disorders using the Generalized Anxiety Disorder-7 (GAD-7) and Standardized Assessment of Personality – Abbreviated Scale (SAPAS) scales included 104 senior-year students of the medical university. In the studied sample, males (n = 46; 44.2%) and females (n = 58; 55.8%) (p < 0.05) were equally represented, the average age of men was 23 (23; 25) years, women – 23 (23; 23) years. Statistical processing was performed using the Pearson’s χ2 test, Mann–Whitney U test to compare independent samples, and the Spearman correlation analysis (r) with a preliminary estimate of the normal distribution.

Results. The data on the statistically significant differences in the level of anxiety and personality disorders depending on gender and age were obtained. Using the GAD-7 scale, the presence of moderate and average level of anxiety in male students was revealed in 26.1%, in female students – in 48.3% (ð = 0.001). The use of SAPAS scale revealed statistically insignificant differences in the studied groups: in males – 4 (4; 6) points, in the group of female students – 4 (3; 5) points (ð = 0.2).

Conclusion. A logistic regression model was obtained that predicted the highest likelihood of development of anxiety disorders.
Amino acids and acylcarnitines as potential metabolomic markers of schizophrenia: new approaches to diagnostics and therapy
Authors: Mednova I. A. , Serebrov V. Yu. , Baikov A. N. , Bohan N. A. , Ivanova S. A.
Published: February 2020

Background. Schizophrenia is a socially significant mental illness with insufficiently studied etiology and pathogenesis. A number of hypotheses of schizophrenia pathogenesis (dopamine, glutamate, kinurenin and serotonin hypotheses) bring together the fact that amino acids are precursors or intermediate metabolic products of these metabolites. Amino acids and their metabolites play an important role as significant substrates and regulators in many metabolic pathways.

The aim of this review is to analyze the literature data on the studies of amino acids and acylcarnitines in patients with schizophrenia.

Methods. A literature search was conducted using PubMed databases for articles published in English and covering the period from the first articles on this topic, dated 1977 to April 2019. Combinations of the following keywords were used to search for “schizophrenia”, “antipsychotics” and “amino acids”, “acylcarnitines”, “metabolomics”.

Results. The review summarizes the data on the content of amino acids and acylcarnitines in the peripheral blood of schizophrenia patients and their dynamics in the course of pharmacotherapy with antipsychotic drugs. The potential of determining amino acids as biomarkers of therapeutic response and side effects, as well as their use in the treatment of patients with schizophrenia, are considered.

Conclusion. Further investigation of the spectrum of amino acids and their metabolites with the using of mass spectrometric methods of metabolic analysis can lead to the discovery of new therapeutic targets and strategies, assess their role in the pathophysiology of schizophrenia, identify mechanisms that ensure the development of antipsychotic antipsychotics, and drug-induced side effects antipsychotics, in particular, metabolic syndrome.
Educação & Formação Journal: balance of scientific production (2016-2018)
Authors: Fialho Lia Machado Fiuza , Sousa Francisca Genifer Andrade de , Nascimento Karla Angélica Silva do
Published: February 2020

The objective is to analyze the scientific production published by the Educação & Formação Journal between 2016-2018, identifying the main educational thematic categories discussed in this triennium. State of art research was used, methodologically supported by categorical analysis of the disseminated articles, considering their title, keywords and abstracts. 101 products were identified, which culminated in five main thematic categories: “Teacher Training”, “History of Education”, “Educational Policy”, “Inclusive Education” and “Technology and Digital Culture”. These were mostly discussed through qualitative research, such as literature review and case study, using literature review, interviews and document analysis. The discussions pointed out that the literature published by Educação & Formação focuses on the subfield teacher training, as proposed by the focus and scope of the journal, making it a reference in this field. The published literature highlights the qualification of teachers of basic education and the gaps regarding the qualification of higher education teachers.
Development and external validation of an online clinical prediction model for augmented renal clearance in adult mixed critically ill patients: the ARC predictor
Authors: Gijsen Matthias , Huang Chao-yuan , Flechet Marine , Daele Ruth Van , Declercq Peter , Debaveye Yves , Meersseman Philippe , Meyfroidt Geert , Wauters Joost , Spriet Isabel
Published: February 2020

Background

Augmented renal clearance (ARC) might lead to subtherapeutic plasma levels of drugs with predominant renal clearance. Early identification of ARC remains challenging for the intensive care unit (ICU) physician. We developed and validated the ARC predictor, a clinical prediction model for ARC on the next day during ICU stay, and made it available via an online calculator. Its predictive performance was compared with that of two existing models for ARC.

Methods

A large multicenter database including medical, surgical and cardiac surgery ICU patients (n = 33258 ICU days) from three Belgian tertiary care academic hospitals was used for the development of the prediction model. Development was based on clinical information available during ICU stay. We assessed performance by measuring discrimination, calibration and net benefit. The final model was externally validated (n = 10259 ICU days) in a single-center population.

Results

ARC was found on 19.6% of all ICU days in the development cohort. Six clinical variables were retained in the ARC predictor: day from ICU admission, age, sex, serum creatinine, trauma and cardiac surgery. External validation confirmed good performance with an area under the curve of 0.88 (95% CI 0.87 – 0.88), and a sensitivity and specificity of 84.1 (95% CI 82.5 – 85.7) and 76.3 (95% CI 75.4 – 77.2) at the default threshold probability of 0.2, respectively.

Conclusion

ARC on the next day can be predicted with good performance during ICU stay, using routinely collected clinical information that is readily available at bedside. The ARC predictor is available at www.arcpredictor.com .
Increased Expression Together with the Gene Regulation Network of NEIL3 Predicts Poor Prognosis and Correlates with Immune Infiltrates in Hepatocellular Carcinoma
Authors: Hu Bo , Yang Xiao-Bo , Sang Xinting
Published: February 2020

Background: Abnormal Nei endonuclease VIII-like 3 (NEIL3)expression is associated with carcinogenesis.
Methods: We used sequencing data from the Cancer Genome Atlas database, analyzed NEIL3 expression, gene regulation networks and the correlation with immune infiltrates in hepatocellular carcinoma (HCC). Clinicopathologic characteristics associated with overall survival in TCGA patients using Cox regression and the Kaplan-Meier method. Gene Set Enrichment Analysis was performed using TCGA data set. LinkedOmics was used to identify differential gene expression with NEIL3 and to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. Gene enrichment analysis examined target networks of kinases and transcription factors.Correlations between NEIL3 expression and cancer immune infiltrates and immune gene markers were analyzed by TIMER and GEPIA.
Results: We found that overexpressed NEIL3 predicted poor prognosis. Functional network analysis suggested that NEIL3 regulates the DNA replication and cell cycle signaling via pathways involving several cancer-related kinases and E2F Transcription Factor 1.NEIL3 was also found to be associated with the infiltration of several immune cells.
Conclusions: Our results demonstrate that data mining efficiently reveals information about NEIL3 expression, potential regulatory networks and the relationship with immune infiltration in HCC, laying a foundation for further study of the role of NEIL3 in carcinogenesis.
Plasma APRIL as a Potential Biomarker in the Diagnosis of Obstructive Sleep Apnea
Authors: Wen Wan-Wan , Sun Hai-Li , Yang Yun-Xiao , Jia Yi-Fan , Huang Meng-Ling , Du Yun-Hui , Qin Yan-Wen , Fang Fang , Zhang Ming , Wei Yong-Xiang
Published: February 2020

Background: Obstructive sleep apnea (OSA) is the most common type of sleep breathing disorder and is characterized by chronic intermittent hypoxia, which could cause inflammation and NF-KB-dependent inflammatory pathways activation. Circulating APRIL might play an important role in promoting inflammation and NF-KB-dependent inflammatory pathways activation. We explored the role of APRIL as a potential mechanism of inflammation in OSA patients. Methods: After detailed sleep evaluated, venous blood and demographic data were collected from 155 subjects with varying severity of OSA and 52 control subjects. Plasma levels of APRIL were measured by human Magnetic Luminex assay. Results: Plasma APRIL levels were significantly higher in OSA subjects compared with control subjects. Categorization of the OSA subjects into mild, moderate, and severe OSA subgroups showed that plasma levels of APRIL increased with severity. After adjusting confounding factors, found that increased plasma APRIL levels were conferred a higher odds ratio (OR) of OSA. Moreover, plasma APRIL levels were positively associated with the apnea-hypopnea index. Furthermore, plasma APRIL showed higher discriminatory accuracy in predicting the presence of OSA. Conclusions:Plasma APRIL levels were significantly associated with the occurrence of OSA and its severity. APRIL could be a plasma biomarker with a positive diagnostic value for inflammation and NF-KB–dependent inflammatory pathways activation in subjects with OSA.
Cemented versus uncemented arthroplasty for the management of femoral neck fractures in the elderly
Authors: Li Lang , Yang Xiaodong , Jiang Jun , Yang Lei , Xing Fei , Tang Xueyang
Published: February 2020

Background Hemiarthroplasty and total hip arthroplasty (TKA) are commonly used to treat unstable femoral neck fractures in older patients. However, there is no consensus on the use of cement during hemiarthroplasty and TKA. Previous reviews on this subject included small number of studies and lacked evidence grading of outcomes. In this study, we aimed to compare the outcomes of cemented and uncemented arthroplasty for the treatment of femoral neck fractures in older patients. Methods A meta-analysis was conducted according to the guidelines of the Cochrane Collaboration using online databases (Pubmed, Cochrane Central Register of Controlled Trials, and Ovid). The quality of the included studies was assessed using the Cochrane Collaboration tool and Newcastle-Ottawa Scale. Prospective cohort studies and randomized controlled trials (RCT) of cemented arthroplasty versus uncemented arthroplasty for treatment of femoral neck fractures were analyzed using Review Manager (version 5.2) software. Results Sixteen studies were included in the meta-analysis. Cemented arthroplasty was found to be superior to uncemented arthroplasty with respect to reoperation rate, complications related to prosthesis, residual pain, and operation time. There were no significant between-group differences with respect to local and general complications, duration of hospital stay, hip function, and mortality. Conclusion Compared with cemented arthroplasty, uncemented arthroplasty was associated with a greater risk of complications related to prosthesis, reoperation rate, residual pain, and longer operation time. However, the results of this meta-analysis should be interpreted cautiously owing to some limitations. Further studies are required to provide more robust evidence.