bluuebunny/crossref_metadata_2025 huggingface dataset:
The Crosstalk between Nephropathy and Coagulation Disorder: Pathogenesis, Treatment, and Dilemmas
Authors: Qiu Zhiwei , Pang Xiaocong , Xiang Qian , Cui Yimin
Published: July 2023

The interaction between the kidney and the coagulation system greatly affects each other because of the abundant vessel distribution and blood perfusion in the kidney. Clinically, the risks of complicated thrombosis and bleeding have become important concerns in the treatment of nephropathies, especially nephrotic syndrome, CKD, ESKD, and patients with nephropathy undergoing RRTs. Adverse effects of anticoagulant or procoagulant therapies in patients with nephropathy, especially anticoagulation-related nephropathy, heparin-induced thrombocytopenia, and bleeding, seriously worsen the prognosis of patients, which have become challenges for clinicians. Over the decades, the interaction between the kidney and the coagulation system has been widely studied. However, the effects of the kidney on the coagulation system have not been systematically investigated. Although some coagulation-related proteins and signaling pathways have been shown to improve coagulation abnormalities while avoiding additional kidney damage in certain kidney diseases, their potential as anticoagulation targets in nephropathy requires further investigation. Here, we review the progression of research on the crosstalk between the coagulation system and kidney diseases and systematically analyze the significance and shortcomings of previous studies to provide new sight into future research. In addition, we highlight the status of clinical treatment for coagulation disorder and nephropathy caused by each other, indicating guidance for the formulation of therapeutic strategies or drug development.
Dutch Sexologist perceptions on monitoring nocturnal erectile function
Authors: Evelien J Trip , Melianthe P Nicolai , Henk W Elzevier , Rob CM Pelger , Jack JH Beck
Published: July 2023

Background: There has been a long-standing interest in assessing male sexual function over the past number of decades. Erectile Dysfunction (ED) is commonly classified as organic, psychogenic, or mixed. Aim: The principal aim of this questionnaire was to determine the ways in which Dutch healthcare professionals (sexologists) define the type of ED in their daily practice. The second aim was to evaluate sexologists’ opinions regarding their experiences with the Rigiscan and the desired aspects of a yet-to-be-developed successor. Methods: We performed an anonymous survey study. A questionnaire with 21 items was mailed to all participants of the Dutch Association of Sexology. To obtain a higher response rate the survey was sent three times. The questionnaire was designed by two Dutch sexologists from the Sint Antonius Hospital. The survey questions were pre-tested, and after making changes to the questionnaire it was pilot tested. Outcomes: Eighty-eight people responded and sixty-six respondents completed the survey. Results: The majority of respondents reported that information obtained by a thorough sexual history, according to the biopsychosocial model, is sufficient to diagnose the cause of ED and enable them to provide the correct therapy. For additional diagnostics, respondents indicate to refer to a urologist for physical examination, basic laboratory tests, or, if necessary, advanced examinations such as a nocturnal penile tumescence measurement. 83% of respondents said to use a simple sensor to differentiate the cause of ED if this would be available. Features respondents mentioned of a future sensor where: validated, patient-friendly, and easy to use at home. Clinical implications: The data provide information to develop a new sensor to measure nocturnal erections. Strengths & limitations: Study strengths include: The first report among Dutch sexologists about usage and needs for nocturnal erections measurements. Study limitations include a non-validated questionnaire. A diverse group of Dutch sexologists, not many medical sexologists. Low response rate. Conclusion: The participating sexologists indicate a need for more clarity regarding the different tools which could be useful for the differentiation between primary organic and primary psychogenic ED. A new validated, patient-friendly sensor that can be used by patients in their home setting was appointed to be helpful.
Grado de aceptación de los sistemas de evaluación digitales adaptados al uso de recursos tecnológicos educativos basados en Realidad Aumentada
Authors: Delgado-Rodríguez Santiago , Carrascal-Domínguez Silvia , García-Fandiño Rebeca
Published: July 2023

The use of immersive technologies, especially Augmented Reality (AR), is presently one of the main technological trends in the field of education. Some studies carried out in recent years in this field highlight that traditional evaluation systems continue to be used and raise the possibility of using adapted evaluation systems. This research, based on primary sources of information, seeks empirical evidence regarding the need to use digital evaluation systems adapted to technological resources in Science subjects and in stages of Compulsory Secondary Education. The methodology used is quantitative research based on the design and statistical analysis of the responses given by students to a questionnaire created ad hoc, administered to assess an AR educational resource used in class to explain a key concept in connection with the subject. The results obtained through the exploratory factorial analysis of the students’ answers reveal, as a latent construct, a high level of acceptance of the digital evaluation system used. The analysis of the data obtained in this study allows us to establish the hypothesis that a digital evaluation system adapted to the use of an immersive AR technological resource can generate a positive impact on the students' learning process.
Recursos Educacionais Abertos (REA) nas teses e dissertações brasileiras entre 2002 e 2019
Authors: Cavichioli-Lauermann Rosiclei Aparecida , Mallmann Elena Maria
Published: July 2023

An analysis of the research scenario on integrating OER in the teaching-learning process is systematized. We analyzed 118 pieces of research produced in Brazil from 2002 to 2019, composing a set of 25 dissertations, 57 academic theses, and 36 professional theses. The texts were extracted from the databases of the CAPES Catalog of Dissertations and Theses and the Digital Library of Dissertations and Theses (BDTD, from the Portuguese Biblioteca Digital de Teses e Dissertações). The scenario design started from the aggregation of results focusing on a) the temporal evolution of the research, b) the localities, c) the administrative dependence of the Teaching Institutions, and d) the area of knowledge. Complementarily, the findings from the four guiding questions made it possible to conclude that there were few pieces of research investigating the integration of OER in the teaching-learning process, especially within the context of Technical and Vocational Education (TVE) and Graduate School. Moreover, the study revealed that, among the 5Rs of OER, the practice most promoted by the pieces of research within the scope of the teaching-learning process was reuse, which is directly associated with retain and redistribute. This indicates the need to expand and strengthen the continuing education actions aimed at the practice of the other two Rs: revise and remix. Finally, the study pointed out the need for research that performs articulations with educational public policies so that they may generate creation and sharing, in addition to consolidating the international open education movement.
A Xiphoid Elongation Following a Trauma Laparotomy: A Case Report
Authors: Min Soon Ki , Jeon Sebeom , Lee Jungnam , Choi Kang Kook , Yang Hyuk Jun
Published: July 2023

Xiphoid elongation is a rare phenomenon where the xiphoid process elongates after stimuli such as surgery, physical therapy, or trauma. We report on a 47-year-old male involved in a traffic accident who went into cardiac arrest. He received ongoing cardiopulmonary resuscitation for nine minutes before recovery of cardiac rhythm, and transfer from a local hospital to the trauma center. He received management for hypotensive shock which was temporarily corrected using Resuscitative Endovascular Balloon Occlusion of the Aorta, and underwent trauma laparotomy in which ileocolic artery ligation and a splenectomy were performed. Six months later, the patient reported epigastric discomfort when he bent over. A hard, linear mass was palpated along the upper midline incision scar and a computed tomography scan showed an elongated xiphoid process (10 cm). The patient underwent surgical excision, and electrocauterization of the xiphoid process. This is a rare case of xiphoid elongation following multiple stimuli to the xiphoid process.
Potential use of electrochemically synthesized silver nanoparticles on rice panicle blight pathogen, Burkholderia glumae
Authors: Chaves-Bedoya Giovanni , Padilla Hilda Angélica , Ortiz-Rojas Luz Yineth , Peña-Rodríguez Gabriel
Published: July 2023

Burkholderia glumae, is the main causal agent of bacterial panicle blight (BPB) in rice (Oriza sativa), a disease that generates production losses worldwide. Despite its economic importance, effective control measures and rice varieties with complete resistance to this disease have not yet been available. In this study, the antimicrobial activity of electrochemically synthesized silver nanoparticles (AgNPs) against B. glumae was evaluated. The AgNPs were synthesized with a DC power supply (UNI-T®) regulated at 24 V, which was connected to two cylindrical electrodes of high purity silver (Aldrich-99.99%) using distilled water as an electrolyte. The AgNPs concentration was determined by measuring the total dissolved solids (TDS) with a HandyLab 680 FK multiparameter. The antibacterial activity of these nanoparticles against B. glumae was determined by the broth macrodilution method at different concentrations (1-10 mg L-1). The minimum inhibitory concentration (MIC) was determined in 5 mg L-1 of AgNPs. The results revealed that AgNPs are a promising nanopesticide for controlling the BPB disease in rice.
Could the production region influence the quality and antioxidant activity of cashew apple?
Authors: Almeida Maria Lucilania Bezerra , Moura Carlos Farley Herbster , Innecco Renato , Silveira Márcia Régia Souza da , Brito Edy Sousa De
Published: July 2023

Given the scarcity of research related to the interference of the climatic elements under the qualitative characteristics of the cashew apples, this work had the objective of evaluating the quality and total antioxidant activity of cashew apple of dwarf cashew in different climatic conditions. The experimental design was completely randomized, in a factorial scheme with repeated measurement in time, with three clones (CCP 09, BRS 265 and PRO 555-1) in two regions, cearense semiarid, sertão (Alto Santo – CE) and a coast (Beberibe – CE), with four replications and evaluated in different years. In the laboratory, the fruits were processed to obtain the pulp and evaluated for: soluble solids (SS, °Brix), titratable acidity (TA, % malic acid), SS/TA, soluble sugars (AS, % glucose), vitamin C (mg/100 g), total extractable polyphenols (TEP, mg L-1), cinnamic acid (CA, mg L-1), transcinnamoyl glycoside (TG, mg L-1) and total antioxidant activity (TAA, μmol Trolox/g). It was observed highest values of SS, TA, AS, vitamin C, TG, TEP and TAA obtained in cashew apple in the sertão. The ‘CCP 09’ showed higher quality to the others, responding in a positive way to the variations of environments conditions. The quality and antioxidant activity of cashew apple are influenced by the climatic elements of each region, as well as the year of production and the genotype. The antioxidant activity attributed to the cashew apple showed to be more strongly related to TEP and transcinnamoyl glycoside content.
Base temperature for a phenological stage in plum cultivar Horvin (Prunus salicina Lindl.)
Authors: Orjuela-Angulo Mayerlin , Parra-Coronado Alfonso , Camacho-Tamayo Jesús Hernán
Published: July 2023

The plum (Prunus salicina Lindl.) is affected by the amount of water provided by its environment, as conditioned by climatic factors, especially temperature. Fruit development, in terms of physiological time or growing degree-days (GDD), is more accurate than quantification in terms of crop scheduling dates. The objective of this research was to determine the base temperature (Tb) of the phenological period between fruit set and harvest in Horvin plums and to express this duration in terms of GDD to determine the harvest date. Twenty trees were marked per locality at four different altitudes (2,449; 2,285; 2,215 and 2,195 m) in the municipality of Nuevo Colon, Boyaca. During 2015 and 2016, the dates of fruit set and harvest were recorded. Tb was estimated using different methods, as well as the GDD required to go from fruit set to harvest. The variance showed the best statistical fit between coefficient of variation and standard deviation for estimating Tb, with a high degree of correlation. The Tb for this phenological period was 2.9ºC. The results showed that a mean of 1,528 GDD and 81 days were required to pass from fruit set to fruit harvest.
Effect of some edaphic conditions on physicochemical and physiological characteristics of ‘Horvin’ plum fruit
Authors: Orjuela-Angulo Mayerlin , Dussán-Sarria Saúl , Camacho-Tamayo Jesús Hernán
Published: July 2023

Edaphic conditions are determinant factors of fruit quality at harvest. The objective was to establish which edaphic variables influence fruit harvest and to determine the influence of these variables on some physicochemical and physiological characteristics of ‘Horvin’ plum fruits at harvest. In the municipality of Nuevo Colon (Boyaca, Colombia), records of two harvests were made in four locations during 2015 and 2016. Ten trees per row and twenty trees per location were marked, for a total of 80 trees for the four locations. For the chemical soil analyses, four samples were taken per location at a depth between 20 and 30 cm, for a total of 16 soil samples. For the physical analysis, 6 samples were taken per location at a depth between 20 and 30 cm, for a total of 24 soil samples. The results showed that the bulk density in the four locations was high, which is evidence of high levels of compaction in each location, resulting in low fruit development at harvest. A relationship was found with fruits at harvest in characteristics such as weight and diameter for some chemical variables, such as pH, phosphorus, cation exchange capacity, calcium, magnesium, potassium, zinc, copper, boron and sulfur.
Variability, correlation, and path analysis in erect and prostrate cultivars of cowpea (Vigna unguiculata [L.] Walp.)
Authors: Araméndiz-Tatis Hérmes , Espitia-Camacho Miguel , Cardona-Ayala Carlos
Published: July 2023

The cowpea bean (Vigna unguiculata [L.] Walp.) is the most important legume in the Colombian Caribbean, and is cultivated with genotypes having prostrate growth habit, with yields that do not exceed 700 kg ha-1. Manual harvesting is very expensive for crop rotation in commercial agriculture, which is why cultivars with erect growth habit are required. The research was carried out in the first semester of 2022, in the experimental area of the Universidad de Córdoba (Monteria-Colombia). Sixteen erect genotypes and five prostrate genotypes, including the control, were evaluated under a randomized complete block design with five repetitions. Each experimental unit consisted of two rows of 5 m in length, with a distance between plants of 0.15 m and between rows of 0.40 m for a population density of 166.000 plants/ha. The results indicated genetic variability, which enables successful phenotypic selection, according to the estimated genetic parameters. Likewise, there was positive and significant correlations of performance components with yield. In addition, the unfolding of genotypic correlations by means of path analysis indicated that grain thickness is an important and easy to measure characteristic to increase yield.
Agronomic evaluation of Cannabis sativa (L.) cultivars in northern Colombia
Authors: Araméndiz-Tatis Hermes , Cardona-Ayala Carlos , Espitia-Camacho Miguel , Herrera-Contreras Andrea , Villalba-Soto Alisson
Published: July 2023

Cannabis sativa (L.) is used to obtain fiber, seeds and phytocannabinoids for medicinal and recreational purposes. The commercial production of this species is limited by the lack of knowledge of the agronomic behavior and the content of phytocannabinoids, hence the need for evaluation of genetic diversity, for the selection of cultivars, in accordance with the legal provisions in force in Colombia. The objective of this work was to evaluate the agronomic characteristics and phytocannabinoid content of 10 cultivars, in Pueblo Bello-Cesar, northern Colombia. The study was conducted in 2022, under greenhouse conditions with polycarbonate cover and anti-aphid mesh. We evaluated 10 clones of territorial seed source, using cuttings of 13 cm in length, of female plants. The rooted cuttings were planted in 6 L bags, in a mesh house until harvest. The randomized complete block design was used, with 10 treatments and three repetitions. Each experimental unit consisted of 20 plants, with a density of 16 plants/m2, both in the vegetative and reproductive phases, with distances between plants and rows of 14 cm. Genetic variability was estimated in both vegetative and reproductive characteristics and phytocannabinoid content. Three groups of genotypes were identified, according to the combinations of alleles coding for the phytocannabinoid content: high THC (tetrahydrocannabinol), similar THC-CBD ratio and high CBD (cannabidiol), which determines their potential use, mainly in medicine.
Caracterización físico-química y capacidad antioxidante de progenies de quinua originarias de Colombia, Brasil y Ecuador producidas en la Sabana Brasileña
Authors: Anchico-Jojoa Wilson , Peixoto José Ricardo , Oliveira Júnior Antônio Alves De
Published: July 2023

En la agroindustria, la quinua es considerada un alimento funcional para por sus beneficios para la salud. Sin embargo, es necesario identificar genotipos que proporcionen mejores características fisicoquímicas y alta capacidad antioxidante para la selección en los programas de mejoramiento genético. Este trabajo tuvo como objetivo evaluar la composición fisicoquímica y la capacidad antioxidante de genotipos de quinua originarios de Brasil, Colombia y Ecuador cultivados en condiciones de la Sabana Brasileña (Cerrado). La siembra se llevó a cabo en la Hacienda Agua Limpa de la Facultad de Agronomía y Medicina Veterinaria de la Universidad de Brasilia, ubicada a 15º56' S y 47º55' O, a una altitud de 1.100 m. El análisis fisicoquímico se realizó en año 2021 en el Centro de Investigación de Alimentos de la Universidad de Passo Fondo, Río Grande do Sul, y el análisis de capacidad antioxidante se realizó en la Universidad de Santiago de Chile. Se determinó el contenido de humedad, cenizas, proteínas, carbohidratos (CHO), fibra bruta, lípidos y capacidad antioxidante. Los datos originales fueron sometidos a análisis de varianza, mediante la prueba F (P≤0,05), y la comparación de medias por la prueba de Tukey. Se realizarón análisis de correlación lineal (Fischer) (P≤0,01) y (P≤0,05), y análisis de agrupación jerárquico por el método Ward. Los genotipos presentaron variabilidad en las características fisicoquímicas y actividad antioxidante. Los CHO fueron los compuestos mayoritarios presentes en las semillas, mostrando un promedio de 50,16%, el promedio de proteína fue del 15,27%, con mayores resultados para el genotipo P88 (16,28%). El contenido promedio de lípidos, fibra y cenizas fueron 3,24; 14,13 y 6,0%, respectivamente. Los CHO mostraron una correlación positiva con el parámetro lipídico (r=0,858) y una correlación negativa significativa con la proteína (r=-0,785). El cultivar Aurora expresó una mayor actividad antioxidante (1,96±0,01 mg Trolox/g).
The role of microRNAs in the development of gastric and duodenal ulcers
Authors: Sagadatova Yulia R. , Khasanov Anvar G. , Gilyazova Irina R. , Sufiyarov Damir I. , Sufiyarov Ildar F.
Published: July 2023

The research highlights the fundamental concepts of microRNA, the mechanisms of RNA interference, the importance of microRNA in the development of diseases. Combining the experience of domestic and foreign researchers, the authors identified the main miRNAs involved in the development of gastric and duodenal ulcers. The article also describes the main mechanisms of regulation of the inflammatory process in gastric and duodenal ulcers associated withHelicobacter pylori, the influence of microorganisms on the expression of various microRNA types and the control of the cellular immune response. In addition, the review presents the latest research on methods for diagnosingHelicobacter pylori-associated peptic ulcer based on the determination of circulating microRNAs. The results of an experimental model of treatment of patients infected with Helicobacter pylori with drugs that act on non-coding RNA are presented.
To the 200th anniversary of the beginning of pediatric education in the Republic of Tatarstan: pages of the life of the outstanding pediatrician Pyotr Mikhailovich Argutinsky-Dolgorukov
Authors: Pikuza Olga I. , Fayzullina Rezeda A. , Zakirova Alfiya M. , Samorodnova Elena A. , Volyanyuk Elena V.
Published: July 2023

The paper describes the main milestones in the life of one of the founders of the pediatric school in Kazan Professor P.M. Argutinsky-Dolgorukov. He made a lot of efforts to organize the teaching of pediatrics at the Kazan Imperial University, was one of the initiators of the construction of a new children's clinic on the Arsk field in 1900. Professor P.M. Argutinsky-Dolgorukov connected mainly with the study of infectious pathology. His students Professor V.K. Menshikov, E.M. Lepsky, A.A. Agafonov later became well-known pediatricians and infectious disease specialists who took an active part in the creation of pediatric and infectious diseases services in the Republic of Tatarstan. P.M. Argutinsky-Dolgorukov was the founder of the study of malaria in children in Russia. Under the guidance of the professor, progressive methods of diagnostics and treatment were introduced into clinical practice, in particular, the method of treating scarlet fever with Moser's serum, the study of the measles causative agent, and X-ray examinations at the patient's bedside.
The 2017 North Carolina STOP Act is Associated With an Accelerated Decrease in Opioid Dispensing: A Statewide Analysis, 2013–2019
Authors: Gillette Chris , Brooks Amber K. , Bodner Gayle B. , Perry Courtney J.
Published: July 2023

Background

This study aimed to: 1) quantify the dispensing and days’ supply of opioid prescriptions prior to and after the NC STOP Act went into effect among Medicare Part D beneficiaries; 2) evaluate how the STOP Act impacted physician assistant and nurse practitioner opioid prescribing; and 3) evaluate whether the NC STOP Act is associated with reductions in opioid prescriptions’ days’ supply among Medicare Part D beneficiaries.

Methods

This was a secondary analysis of Medicare Part D Public Use Files for 2013–2019. Only North Carolina providers and select Schedule II (CII) and III (CIII) drugs and tramadol (CV) were included in the analysis. Multivariable Poisson regression models were used to analyze the data.

Results

In 2013, there were population-adjusted 180,565.2/100,000 claims for the included CII and CIII opioids, which decreased to 79,329.12/100,000 claims in 2019. Each of the multivariable Poisson regression models indicates a reduction in per-provider populationadjusted claims and days’ supply after the NC STOP Act went into effect for both selected CII and CIII medications and for tramadol. The results also indicate that the number of prescriptions for CII, CIII, and tramadol decreased over time.

Limitations

Due to the nature of the observational study design, we cannot conclude that the 2017 legislation had an effect on populationadjusted claims for certain CII and CIII opioids.

Conclusions

Since 2013 there has been a decreasing trend in certain CII and CIII opioids dispensations in Medicare beneficiaries, and the trend accelerated after the STOP Act went into effect.
Peristomal Hidradenitis Suppurativa: A Case and Review of the Literature
Authors: Sosh Daniel , Varra Vamsi , Kaffenberger Jessica
Published: July 2023

Hidradenitis suppurativa (HS) is a chronic, inflammatory condition of apocrine gland-bearing skin that typically presents as deep, inflamed lesions in the axillary, inguinal, perineal, and mammary regions. We present a rare case of a man in his 60s with a history of HS who presented with a peristomal sinus tract, as well as non-healing, draining wounds around his stoma site that responded well to adalimumab therapy. A compounded clobetasol ointment with poly(ethelyene oxide) polymers (POLYOXTM, Dupoont) was utilized to maintain stoma appliance adhesion, and his lesions effectively cleared with adalimumab.
Введение в теорию полугрупп : учебное пособие для магистров и аспирантов физико-математического факультета
Authors:   Саратовский государственный университет, Поплавский В. Б. , Поплавский Д. В. ,   Саратовский государственный университет
Published: July 2023

Данное издание представляет собой введение в теорию полугрупп. Оно содержит систематическое изложение как классических, так и новых результатов исследования по теории полугрупп. Многочисленные подробно разобранные здесь примеры часто не только носят иллюстративный характер, но и дают дополнительные сведения к основному содержанию. Для магистров и аспирантов физико-математического факультета.
Trends in Behavioral and Biological Non-Communicable Diseases Risk Factors among Adults in Mongolia: Results from National Cross-Sectional Surveys in 2005, 2009, 2013 and 2019
Authors: Pengpid Supa , Peltzer Karl
Published: July 2023

Background: Understanding national trends in noncommunicable disease (NCD) risk factors may have health policy implications. We aimed to evaluate trends in the prevalence and correlates of eight risk factors for NCD from 2005 to 2019 in Mongolia.
Methods: Cross-sectional data were analyzed from 9,356 individuals (15-64/69 yr, mean age=37.3 yr) who participated in the Mongolia STEPS 2005, 2009, 2013 or 2019 surveys and had complete measurement of the risk factor for NCD.
Results: The proportion of having 3-8 NCD risk factors significantly decreased from 59.1% in 2005 to 49.4% in 2019, and the mean number of NCD risk factors significantly decreased from 2.8 in 2005 to 2.6 in 2019. In linear regression analyses by study year, older age and male sex were across all study years positively associated with eight NCD risk factors. The prevalence of low physical activity increased from 8.2% in 2005 to 28.4% in 2019, overweight/obesity from 49.6% in 2005 to 64.0% in 2019, and raised total cholesterol from 23.9% in 2005 to 27.6% in 2019, there was a significant decrease in inadequate fruit and vegetable intake from 85.1% in 2005 to 79.5% in 2019, current smoking from 26.6% in 2005 to 24.1% in 2019, hypertension from 28.2% in 2005 to 23.2% in 2019, while the prevalence of diabetes remained unchanged from 2005 to 2019.
Conclusion: The prevalence of eight risk factors for NCD decreased in the last 15 years in Mongolia. Several associated variables for eight and individual NCD risk factors were identified that can help guide interventions.
Comparison of Serum Gamma Glutamyl Transferase Levels between Prostate Cancer Patients and Their Healthy Peers
Authors: Yuce Ahmet , Keles Mevlut , Benli Erdal , Cirakoglu Abdullah , Yazici Ibrahim , Nalbant Ismail
Published: July 2023

Background: Prostate cancer (PCa) is the most common cancer affecting men, apart from cutaneous cancers. Serum prostate specific antigen (PSA) levels are frequently used to predict prostate cancer diagnosis. However, many causes (e.g., prostatitis, benign prostate obstruction, urethral catheterization) may cause elevated PSA, in addition to PCa. We aimed to investigate the gamma glutamyl transferase (GGT) levels, a serum biomarker not affected by situations other than cancer causing elevated PSA.
Methods: The study evaluated male patients with prostate biopsy due to high serum PSA levels and/or abnormal digital rectal examination (DRE) examined in Ordu University Education and Research Hospital, Ordu/Turkey urology clinic from April 2019 to April 2021. The patient group in the study included 261 men with PCa diagnosis and the control group included 245 healthy men with normal PSA levels, and no PCa and/or benign prostate obstruction (BPO). The two groups were compared in terms of serum GGT levels.
Results: GGT was significantly low in the PCa group and might be a predictor in terms of PCa (P=0.000). In the malignant (PCa) group, the GGT cut-off value was identified as 21.5 (sensitivity 68.6%, specificity 54.4%).
Conclusion: Serum GGT levels might assist in diagnosis of PCa. However, diagnostic power is weak due to low specificity. There is a need for studies investigating the efficacy of GGT levels for prediction of PCa diagnosis and assessing other parameters alongside GGT.
Nanoemulsion of Spiramycin against Tachyzoites of Toxoplasma gondii, RH Strain: Preparation, Toxicology, and Efficacy Studies
Authors: Hashemi-Hafshejani Saeideh , Amani Amir , Azami Sanaz Jafarpour , Valian Hossien Keshavarz , Mohebali Mehdi , Salimi Mahboobeh , Hassani Lafmejan Pour Hossien , Shojaee Saeedeh
Published: July 2023

Background: Toxoplasma infection is caused by Toxoplasma gondii, which is an intracellular protozoan parasite. This infection consequently lead various congenital disabilities during pregnancy in patients. Spiramycin (Spi), a macrolide antibiotic, is typically recommended for T. gondii infection in pregnant women. We aimed to prepare the nanoemulsion of spiramycin (NE-Spi) and to evaluate the activity of this formulation in tachyzoites of T. gondii, RH strain.
Methods: This study was conducted in 2019-2021 at the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. NE-Spi was prepared by spontaneous emulsification. The effects of this nanoemulsion on the viability of cultured cells were measured using MTT assay. To estimate the effects of NE-Spi on tachyzoites of T. gondii, RH strain, different concentrations of NE-Spi, S-Spi (suspension of spiramycin), and NE (nanoemulsion without any spiramycin) were added to tachyzoites and then stored for 30, 60, 90, 120 min and 24 h in 250 µg/ml concentration at room temperature. Finally, Tachyzoites mortality rates were evaluated by trypan blue staining. Of note, flow cytometry was conducted to confirm the obtained results.
Results: The final particle size of NE-Spi was calculated to be 11.3 nm by DLS and TEM. Thereafter, using MTT assay, in 62.5 µg/ml concentration of NE-Spi, the Vero cells viability was obtained as 82%. The highest mortality rates of tachyzoites of T.gondii, RH strain were observed at 250 µg/ml concentration and after 120 min of exposure, but it was not significantly different from 24 h of exposure.
Conclusion: NE-Spi has lethal efficacy on T. gondii RH strain in-vitro.
Potentially Infectious Helicobacter pylori in Tap Water in Kermanshah, Western Iran
Authors: Hasanvand Banafsheh , Bakhtiari Somayeh , Kashef Mahsa , Abiri Ramin , Alvandi Amirhooshang
Published: July 2023

Background: Although the pathogenesis of Helicobacter pylori is well-defined, the origin and transmission of the bacterium have remained largely unknown. The water transmission hypothesis suggested that water acts as a carrier in oral-fecal transmission, especially in high-prevalence areas. We aimed to evaluate the possible contamination of tap water with infective H. pylori in Kermanshah, Iran from Sep-Oct 2020.
Methods: Tap water samples were collected from varieties of probable high-alert regions and the viability of H. pylori were achieved using culture and real-time PCR techniques (ureA gene expression).
Results: Out of 50 tap water samples, 3 were positive for H. pylori before enrichment and 6 were positive after enrichment by RT qPCR, while H. pylori colonies of two samples were observed on brucella agar plates.
Conclusion: The results of positive samples demonstrated the probable presence of viable H. pylori in tap water samples, showing that tap water distribution systems could be a potential route for H. pylori transmission.
Platelet to lymphocyte and neutrophil to lymphocyte ratio in the first trimester of pregnancy, are they useful for predicting spontaneous miscarriage? A case-control study
Authors: Yazdizadeh Maryam , Hivehchi Nafisseh , Ghaemi Marjan , Azizi Sepideh , Saeedzarandi Maryam , Afrooz Narjes , Keshavarz Pegah , Ansarin Melika , Fakehi Maliheh , Yazdizadeh Mina , Mokhtari Mojgan
Published: July 2023

Background: In 15% of all clinical pregnancies, a miscarriage can occur, but the exact cause of this phenomenon is not fully understood. However, it is believed that a faulty placenta, which triggers an inflammatory response in the mother’s body, may be one of the causes. Medical literature has increasingly focused on 2 indicators of inflammation, the plateletlymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR). Despite this, there has yet to be a study conducted that examines the rates of PLR and NLR in cases of miscarriage.
Objective: This study aims to determine whether there is an increase in complete blood count inflammatory parameters such as NLR and PLR in women who experience miscarriages.
Materials and Methods: This retrospective case-control study was conducted from March 2021 to March 2022, across 3 academic hospitals in Tehran, Iran. A total of 240 participants were enrolled comprising individuals with either miscarriages or normal pregnancies (n = 120/each). Data were collected from the medical records of participants aged between 18-42 yr old, with gestational age ranging from 6-13 wk. The demographic information, including age, body mass index, parity, history of abortion, number of abortions, number of living children, hematocrit and hemoglobin levels, platelet distribution width (PDW), PLR, NLR, mean platelet volume, and platelet were extracted from their records. The gestational age was also recorded.
Results: A total of 240 participants were recruited for the study. PDW, NLR, PLR, and lymphocyte values were higher in the miscarriage group compared to the healthy normal pregnant women (p < 0.001). Mean platelet volumes were found to be lower in the miscarriage group compared to the healthy normal pregnant women (p < 0.001).
Conclusion: Although, no statistically significant difference was observed in the hemoglobin, hematocrit, platelets, and neutrophils in these 2 groups of pregnant women. The higher inflammatory markers including PDW, NLR, and PLR could potentially aid in the speculation of defective placentation as a contributing factor to the development of miscarriage. Measurement of these markers may be useful to predict pregnancy leading to miscarriage.
Key words: Spontaneous abortion, Inflammation, Neutrophils, Lymphocytes, Blood platelet, Pregnancy.
Pregnancy outcomes in women with adenomyosis, undergoing artificial endometrial preparation with and without gonadotropin-releasing hormone agonist pretreatment in frozen embryo transfer cycles: An RCT
Authors: Moayed Marzieh Eslami , Moini Ashraf , Kashani Ladan , Mojtahedi Maryam Farid , Rezaee Tawoos , Tabasizadeh Hamed , Maajani Khadije , Yamini Nazila
Published: July 2023

Background: Selecting a suitable and preferable method for endometrial preparation in frozen embryo transfer (FET) cycles for women with adenomyosis is still challenging in infertility treatment.
Objective: To compare 2 artificial endometrial preparation regimens with and without gonadotropin-releasing hormone agonist (GnRHa) pretreatment in women with adenomyosis undergoing FET cycles.
Materials and Methods: This randomized clinical trial study was conducted on 140 adenomyosis cases who underwent FET cycles at Arash Women’s hospital, Tehran, Iran from May 2020 to March 2021. Participants were randomly allocated into hormonal replacement therapy (HRT) and HRT+GnRHa pretreatment groups (n = 70/each). Endometrial preparation with 2-6 mg daily estradiol was started in the HRT+GnRHa group, taking after down-regulation with the GnRHa. Within the HRT group, the same dose of estradiol was commenced within the early follicular stage. The main (chemical and clinical pregnancy rates) and auxiliary results (twin pregnancy, miscarriage, and live birth rates) were compared between groups.
Results: The demographic characteristics and severity of adenomyosis, endometrial thickness, and pattern at starting progesterone administration were similar in the 2 groups, and triple-line endometrium was found to be the dominant pattern in both groups (p = 0.65). No significant differences were observed in chemical, clinical, and twin pregnancy rates as well as miscarriage and live birth rates between groups (p = 0.71, p = 0.81, p = 0.11, and p = 0.84, respectively). However, the total estrogen dose and duration of estrogen consumption were significantly higher in the pretreatment group (p = 0.001, and p = 0.003).
Conclusion: These results indicated that the hormonal endometrial preparation with estrogen and progestin for FET cycles is as efficacious as a protocol involving preceding pituitary suppression with a GnRHa. Further large randomized clinical studies are required to confirm these findings.
Key words: Adenomyosis, Embryo transfer, Hormone replacement therapy, Gonadotropin-releasing hormone.
The Urgency of Waqf in the Agrarian Reform Agenda as a Form of Post-Covid 19 Economic Recovery
Authors: Rafianti Fitri , Medaline Onny , Sembiring Dan Rahmad
Published: July 2023

Waqf is one of the instruments to overcome social and economic problems, meanwhile, agrarian reform is one of the programs that have access to land and is something fundamental for socio-economic development, poverty reduction for handling the Covid- 19 pandemic that has hit the world, especially Indonesia, handling the pandemic requires strategic and clear goals, as illustrated in the design of the concept of Agrarian Reform. This paper aims to analyze the urgency of waqf in the Agrarian Reform agenda as a form of economic recovery after the Covid-19 pandemic. The method used in this study is the Research and development method The results of the study show that in Indonesia the utilization of waqf to overcome economic problems after the Covid-19 pandemic is still not optimal, but waqf has great potential in providing facilities for support economic recovery the urgency of waqf is also appropriate with its needs and functions in the concept of economic recovery in the SHAT (Sertifikat Hak Atas Tanah) program which encourages the rise of MSMEs (Small and Medium Enterprises ) in a cooperation program built by the ministry.
Keywords: Waqf, Agrarian Reform, Economic Recovery, Post-Covid-19
The Termination of Employment Relationship Viewed from Law Number 11 of 2020 about Job Creation and Government Regulation Number 35 of 2021
Authors: . Maiyestati
Published: July 2023

The termination of employment relationship, to workers, means the beginning of all ends, having job, their ability of funding daily life needs for them and their family, their ability of funding their children’s tuition, and etc. However, in fact it cannot be precluded entirely. The problems discussed are: 1) What is the procedure of Employment Relationship Termination Viewed from Law Number 11 of 2020 about Job Creation and Government Regulation Number 35 of 2021? What are the rights the workers get due to the termination of Employment Relationship? Type of research employed in this study is normative/juridical law research conducted by means of studying literature or secondary data only and analyzing it qualitatively, through classifying data by the aspects studied rather than using numbers. The procedure of employment relationship termination, viewed from Law Number 11 of 2020 about Job Creation and Government Law No.35 of 2021, can be done in several ways: 1) the Termination of Employment Relationship should be informed first to the workers, 2) the Termination of Employment Relationship is informed through the first, the second, and the third warnings, 3) the Termination of Employment Relationship with first and the last warnings, without the second warning, and 4) Employer can terminate the Employment Relationship directly. The rights the workers get due to the termination of employment relationship are as follows. The employers obligatorily provide severance pay or long service pay and compensation rights pay the workers should receive. In relation to severance pay, long service pay, and compensation rights pay, the workers are classified into three: 1) Workers who are terminated and given severance pay, long service pay, and compensation rights pay; 2) workers who are terminated without severance pay but given long service pay and compensation rights pay only; and 3) workers who are terminated without severance pay, long service pay, and compensation rights pay, and company only gives a little grant for their family.
Keywords: termination, relationship, employment, job creation
REFLECTION OF DISCRIMINATION OF MUSLIM MINORITY GROUP IN THE NOVEL VERSES OF LOVE 2 ACCORDING TO THE CONCEPT CRITICAL DISCUSSION T.A. VAN DIJK
Authors: Morelent Yetty , Yanti Yusrita , . M. Sayuti , Lestari Lolita
Published: July 2023

The purpose of this research is to describe the reflection of discrimination against Islamic minority groups in the novel Ayat-Ayat Cinta 2 according to Van Dijk’s critical discourse concept. The type of this research was qualitative research using descriptive methods, while the data source of this research was the novel Ayat-Ayat Cinta 2. The data is a reflection of the discrimination of Islamic minority groups. The data collection techniques used were (1) reading and understanding-Ayat Cinta 2novel to obtain a clear understanding of the contents to be studied, (2) marking data that shows discriminatory reflection in the novel Ayat-Ayat Cinta 2, (3) noting all words, phrases, sentences, and paragraphs that reflect acts of discrimination in the novel ”Ayat-Ayat Cinta 2” (4) note-taking techniques were also used to record situations and contexts, and (5) classifying the data according to data collection tables. Based on semantic aspects, local meaningswere found in 99 data, consisting of 10 words, 12 data phrases, 62 data sentences, and 15 paragraphs. Meanwhile, based on implicature and context, 24 data are found. From the results of data analysis, it could be concluded that the reflection of discrimination against Islamic minorities in the novel Ayat-Ayat Cinta 2 was caused by the story that develops in the society of the non-Muslim majority about Muslim minorities in London. They were prohibitions to worship, differences in treatment of minorities, difficulty in getting jobs for women wearing headscarves, insults received by minorities, not being free to use the hijab, injustice for migrants (minorities), and become targets that are claimed as terrorists.
Keywords: Ayat-Ayat cinta2, Reflection Discrimination, Van Dijk Critical Discourse
The Competitiveness of the Tourism Industry in West Sumatera with A Competitiveness Monitor Approach
Authors: Febrina Harahap Erni , . Mora , Muslim Irwan , . Helmawati , Anjely Velya
Published: July 2023

Competitiveness is one of the criteria to determine the success and achievement of a better goal by a country in increasing income and economic growth[1,2]. This study aims to determine the high and low indicators that determine the competitiveness of the tourism sector and the level of competitiveness of the tourism sector in the cities in West Sumatra. In this study, the measurement of the competitiveness of the tourism industry uses eight indicators used by the World tourism organization (WTO) with competitiveness monitor approach[3]. This study uses secondary data. The analytical method used in this study is the tourism index, composite index and competitiveness index. The results of the analysis show that the competitiveness of tourism in the eight indicators is only the Infrastructure Development Indicator (IDI) which shows a low competitiveness value, while the other indicators have high competitiveness.
Keywords: competitiveness, composite index, indicators, contribution, tourism
A Critical Autoethnography of Researching on Environmental Problems from Face Mask Disposal Problems on Malaysia
Authors: GUAN Siyi , XIA Bo , Rasli Amran , Noor Norita Mohd
Published: July 2023

Sharer (referring to storyteller: Siyi Guan) has utilized autoethnography as a methodology to redact and share her own startup experience on the basis of personal business project. The first section comprises the narration of sharer’s personal startup experience, which is followed by the problem statement confronted during the project process, with the introduction of the research design of its methodology at the same time. There have been 5 interviewees participating in this research. Nvivo is utilized to extract the interview data along with its high-frequency words in written form after interviews. Ultimately, the overall project orientation process and future suggestions are elaborated.
Keywords: Autoethnography; Startup experience; Environment; Face Masks
Viscoelastic effects under water-polymer flooding conditions of the fractured-porous reservoir
Authors:   Ivano-Frankivsk National Technical University of Oil and Gas, Pogrebnyak Volodymyr G. , Shimanskii Volodymyr Y. ,   Ivano-Frankivsk National Technical University of Oil and Gas, Pogrebnyak Andriy V. ,   Ivano-Frankivsk National Technical University of Oil and Gas, Perkun Iryna V. ,   Ivano-Frankivsk National Technical University of Oil and Gas
Published: July 2023

The work is devoted to the numerical simulation of the flow of simple and viscoelastic (polymer solution) fluids through a fracture by using polymer solutions for enhanced oil recovery from a reservoir. Polymer solutions have viscoelastic properties. Therefore, when polymer solution flows through the slot, we use the well-known Maxwell’s fluid model with the Jaumann derivative to evaluate deformation characteristics of the flow (stream functions, distributions of the longitudinal velocity gradient and normal stress) resulting in the manifestation of abnormal (compared with the behaviour of the ordinary fluid) effects. The case of slow flow is considered. In this case, the inertial terms can be neglected, the velocities, stresses, and stream functions can be written as the decomposition by Weisenberg number, and we can assume that the Weissenberg number is less than one. The determined regularities of viscoelastic (polymer solution) liquid behaviour with longitudinal velocity gradient and the elastic deformations effects manifested in this case have a decisive meaning in understanding the mechanism of anomalously high oil recovery capacity of a reservoir by using water-polymer flooding of the fractured-porous reservoir. Understanding the nature of the effects of elastic deformations under the conditions of water-polymer flooding of the fractured-porous reservoir enables hydrodynamic calculations of the optimal flow of the polymer solution. One of the main issues that need to be solved when developing the technology for increasing oil recovery from formations using polymer solutions is to determine the optimal flow regime in the fractured-porous reservoir. The calculation results verify the ideas obtained from the experimental solution of this problem concerning the strain-stress state of polymer macromolecules (liquid elements) during polymer flow in the inlet area of the fracture in the oil reservoir and confirm the possibility of using numerical analysis of convergent polymer flow for calculating longitudinal velocity gradients in the inlet area of the fracture and can also serve as additional substantiation of the proposed earlier mechanism for increasing oil recovery from reservoirs by using polymer solutions.