bluuebunny/crossref_metadata_2025 huggingface dataset:
Coherence of the Rules of Sharia Against Pancasila
Authors: Rosidah Zaidah Nur
Published: August 2020

This paper aims to find the coherence of sharia principles towards Pancasila. Pancasila as the philosophical basis of the state has an important role in the life of the nation and state. The principles of sharia are important principles for Muslims in muamalah. The type of research used is normative legal research to find coherence between sharia principles in Pancasila. The approach used is a conceptual approach. Secondary data were collected through literature study. Analyze the data using the syllogism method of deduction and interpretation, where the sharia principle is coherent with Pancasila. The results showed that first, the concept of ownership of property and payment of zakat and justice is coherent with the first, second and fifth precepts of Pancasila. Second, the principle of willingness is coherent with the second principle of humanity which is just and civilized, the principle of equality is coherent with the third principle of Indonesian unity, the principle of honesty and truth is coherent with the principle of the Almighty God and the second principle of fair and civilized humanity, the principle of benefit and mutual advantageous in line with the fifth precepts of social justice for all Indonesian people, the written principle in sharia principles is in line or coherent with the fourth principle of populism, which is led by wisdom in deliberation / marriage.

 

  Keywords: Coherence; Sharia Principles; Pancasila.
Model Land Supply for Land Bank to House Application
Authors: Roestamy Martin
Published: August 2020

This study aimed to find out Land Bank's land supplies to provide land for affordable housing and establish community paradigm for ownership in which building separates from its property. The study was performed using a mixed methodology; namely informative where the primary legal material as a legal framework of housing construction is highlighted by considering legal research conducted with simple legal norms with attention to primary data such as land tenure, land availability, and the amount of housing backlogs that extended to help research. Quantitative data used as a measure of flaws in the application of drugs and legal framework, so that all legal resources can be supplemented with quantitative and qualitative data to find alternatives and open access for LIPs' houses.

 

  Keywords: Land Supply; Land Bank; Affordable Housing.
Discourse on Creating a Special Environmental Court in Indonesia to Resolve Environmental Disputes
Authors: Akhmaddhian Suwari
Published: August 2020

The purpose of this study is to determine the regulation of laws and regulations regarding environmental justice in Indonesia and how the concept of building environmental justice in the justice system in Indonesia. This research can be useful both practically and theoretically, practically. The research method used by researchers is the evaluative analysis method, which is a method of gathering and presenting data obtained to analyze the actual situation and then rational analysis is carried out based on juridical references through library research. The results of the research Regulations on the environment are already available namely Law Number 32 of 2009 concerning Environmental Protection and Management and building an environmental justice system starting from improving human resources namely the Supreme Court by consistently educating and training judges with knowledge of aspects of environmental law life that will later handle environmental cases; The Supreme Court makes a special assembly that handles environmental cases; The Supreme Court creates a special chamber that is integrated with the general court that handles environmental cases; The government is amending the 1945 Constitution specifically Article 24 by adding the judicial environment to the environmental court. The conclusion of the legislation is already available and must be used as well as possible and amend the laws and regulations so that bias can be created specifically for environmental justice.

 

Keywords: Building; Environmental; Justice System.
Setting of Earth Oil Management in Old Wells Based on the Principle Social Justice
Authors: Hanum Willy Naresta
Published: August 2020

This study aims to determine and explain the management arrangements for petroleum mining in old wells based on the principle of social justice. This study uses normative research methods with data sources in the form of primary and secondary legal materials. The results of the study show that the management of petroleum mining in old wells does not yet reflect the principle of social justice because the regulations governing mining occur overlapping multiple interpretations, conflictual and disobedient principles, which in turn creates disharmony between one rule and another.

 

  Keywords: Social Justice; Equitable Benefits; Community Participation.
Reconstruction of Mining Policies on Justice in Lampung Province
Authors: Erina Pane , Yanis Adam Muhammad
Published: August 2020

The purpose of research is to examine the mining potentials and policies that have been implemented in Lampung Province and to reformulate mining policies in Lampung Province, which on the one hand can improve the regional economy, on the other hand while maintaining environmental sustainability. Mining resources are a source of prosperity for the region, but it requires commitment from local governments, public institutions, the private sector and the community to conduct sustainable mining management. Sustainable management is able to meet the needs of the present, in the future and improve the health, prosperity of the environment and surrounding communities. Policies that can be carried out starting from licensing, monitoring post-mining land management, managing mine waste and compiling regulations that can support the realization of green mining and environmental conservation activities. The results of this study indicate that mining management in Lampung Province provides economic value to increase local revenue. However, it must be supported by environment-based policies, because mining activities have the possibility of an environment that becomes uncontrollably damaged. Efforts that can be done by local governments are by paying attention to licensing for managers, providing guidance, supervision, so that mining activities can be controlled and not damage the environment

 

Keywords: Reformulation; Policy; Mining.
Development of Creative Industries as Regional Leaders in National Tourism Efforts Based on Geographical Indications
Authors: Saputra Rian
Published: August 2020

This study aims to examine and explain the role of various parties both government, business and community in synergy to develop Geographical Indications products as creative economic potential to develop national tourism based on regional superior products and Geographical Indications. This research is writing normative law using the legislative approach method. The results of the study show that the growth of the creative industry as a superior product based on geographical indications in Indonesia is quite rapid. Creative Industries as regional superior products based on geographical indications can be used and developed as a tool to attract tourists to visit Indonesia due to their unique characteristics or characteristics, and vice versa tourism has been made a partner by the Directorate General of Intellectual Property to promote Indications products Geographically owned by Indonesia at the global level or in every international tourism event.

 

Keywords: Creative Industries, Geographical Indications, Tourism
STEAM Learning in Early Childhood Education: A Literature Review
Authors: Wahyuningsih Siti , Nurjanah Novita Eka , Rasmani Upik Elok Endang , Hafidah Ruli , Pudyaningtyas Adriani Rahma , Syamsuddin Muhammad Munif
Published: August 2020

This literature review covers articles and books about STEAM (Science, Technology, Engineering, Arts, and Mathematics) in early childhood education. STEAM learning is considered to be an appropriate approach to answering the challenges of the 21st century as it integrates the hard and soft skills needed by children. It is exciting to note that in most articles, STEAM is a popular pedagogical method to improve creativity, problem-solving skills, scientific inquiry and critical thinking, and to provide other cognitive benefits. It is taught in integrated learning in early childhood education and is conducted through children’s daily observation. The literature also discusses that the impact of STEAM learning makes children more active and able to take initiatives in their own knowledge. Teachers who are influenced by the integrated professional development of STEAM positively influence children through their professional learning. Another finding from this review is that experience of STEAM can increase children’s self-confidence. In addition, STEAM learning is considered to be able to integrate the skills needed by children. STEAM encourages children to build knowledge about the world around them by observing, investigating and asking questions. This review aims to consider advanced learning in early childhood education through STEAM.
Directions of development of the services on the basis of modern marketing strategies
Authors: Radjabov Bunyod Abduhalilovich
Published: August 2020

The main problems of development of the services market in the Republic of Uzbekistan are considered in the article. Based on the strategic analysis of the BCG matrix, the development of the services market in the regions is analyzed. Based on the results of the strategic analysis, recommendations for the development of the market of services in the regions of the republic on marketing strategy have been developed
Konstruksi Realitas Sosial:Pemikiran Peter L. Berger Tentang Kenyataan Sosial
Authors: Dharma Ferry Adhi
Published: August 2020

Peter Ludwing Berger is a productive sociologist, especially in the study of the sociology of knowledge. Learning a lot from his teacher, Alfred Schutz, made Berger loudly reject the idea of ​​positivism which for him was more or less inhumane compared to the flow of phenomenology. Through the concept of sociology, Berger's knowledge sees reality as two: objective and subjective. Berger agrees with Karl Marx's anthropological presupposition about the objective reality of humans as a socio-cultural product, however, in the subjective reality, human beings are organisms that have certain tendencies in society and are interpretive. To understand what is real for society, Berger formulates his theory of reality construction in three stages: externalization, objectification, and internalization.
Jaringan Komunikasi dalam Penanganan Gizi Balita di Posyandu Desa Medalem Kecamatan Tulangan Kabupaten Sidoarjo
Authors: Rochmaniah Ainur , Syamsudin Muhammad
Published: August 2020

Child nutrition problems is an important thing that concerns parents in maintaining growth of children. Based on observation in Medalem on june 2016 have beenfound 4 cases, is 2 obesity cases of child and 2 malnutrition cases of child. This is indicates an increase incasesof child nutrition problems from 2014. There are socialization activities of infant and child feeding and child nutrition handling by midwives and Posyandu cadres. The purpose of this study is analyze and describe the pattern of information flow about child nutrition in Medalem. The type of this study is quantitative research using communication network analysis techniques. The sample of this study is using snowball sampling techniques. The result of this study are;(1) the patter of communication network formed is Wheel network (formal), gossip network (informal) and all channels network; (2)The opinion leaders in communication network has an important role to influenceing the people who are in the area of communication nerwork;(3) Based on the pattern of communication network, the opinion leaders have high heterogeneity in the level of mastery of innovation abaout nutrition of  the toddler and choose a multi direction communication relationship in the communication process so that opinion leaders included in innovative society.
Pemberitaan Hutang Indonesia Dalam Bingkai Media Online
Authors: Kamelia Fajriatul , Nusa Lukman
Published: August 2020

In Indonesia the ownership of online media is generally controlled only in the hands of a few people. The practice of this media conglomerate is considered a logical consequence of the development of the business world. Finally, the content of all media in Indonesia has become similar to each other and contains the interests of each media owner. For this reason, this study aims to see how online media Okezone.com and Viva.co.id in reporting Indonesia's debt reporting continues to roll throughout 2018. In analyzing, this study uses the analysis method of Zhongdang Pan and M. Gerald Kosicki framing for know how Okezone.com and Viva.co.id in framing reporting on Indonesian Debt in April 2018. The results showed that Okezone.com and Viva.coid lacked weight in framing the news. Okezone.com framed to show its alignment by posting news that constructed that Indonesia's debt was still at a safe level and debt was a natural thing. While Viva.co.id framed the news in favor of the Jokowi government. Viva.co.id emphasizes that the Indonesian government has a good ability to manage debt.
Pemberitaan Media Tentang Transgender Perempuan di Madura
Authors: Aziz Abdul , Wardi Mohammad
Published: August 2020

This study focuses on the news about the existence of female transgender (transpuan) on the island of Madura, the news about transpuan Madura in different media, namely merdeka.com, okezone.com, suarajatimpost.com and suarapamekasan.com. The research method used in this research is the method of literature research, literature study on research dominated by non-field data collection. The results show first, the existence of transpuan in Madura in the public sphere is no longer seen as a marginal group. Secondly, Journalists from a number of media in charge of coverage in Madura, able to present objective values about the role of transpuan in the public sphere. Third, transpuan that was appointed to civil servants gives a picture to the public that gender is not a fundamental issue for the Maduranes as a minority and marginal groups that are considered outside the line of reasonableness.
Efektivitas Proses Komunikasi Interpersonal Antara Pembina Dengan Anak Asuhnya di Sanggar Merah Merdeka Surabaya
Authors: Wono Hilda Yunita
Published: August 2020

Researchers want to know that is not happen in the process interpersonal communication as well as improvement interpersonal communication between shelter comitee and foster kids in the Sanggar Merah Merdeka, which ultimately determine the achievement of the shelter's goals. This study uses quantitative descriptive methods that are used to describe and analyze social events and activities, as well as beliefs, attitudes, perceptions, and thoughts individually or in groups to get a picture of the effectiveness of interpersonal communication carried out in daily life between the comitee of the "Sanggar Belajar Merah Merdeka" with his foster kids. Based on research results. messages according to the purpose of the studio, communication channels, communicant, interference, feedback in the shelter activities daily. Nothing to miss about demonstrates openness, empathy, communication supporting attitudes, positive attitudes, and equality also always emerge.
Fenomena Internet Addiction Disorder Pada Gen Z
Authors: Putra Ogianto , Fitriani Dinda Rakhma
Published: August 2020

This research aims to determine and analyze thePhenomenon Internet Addiction Disorder of Gen Z.The method used is a descriptive qualitative approach, in which the researcher makes observations involved, structured interviews that have been made previously with reference to aspects or indicators of existing variables.The theory used is the CMC (Computer Mediated Communication) theory and the Lifestyle theory.The results show that the role of social media Instagram has a huge impact on progresslifestyle of the younger generation.Instagram it's not just to post pictures and videos, but makes it easy for users to find information or anything they want. Even thoughInstagram has many positive impacts, for them it is possible to have many negative impacts. The negative impact of excessive use of social media can reduce the social, health and mental illness of the younger generation.
Implementasi Kebijakan Pemerintah Kabupaten Sumenep Dalam Rangka Pengembangan dan Pelestarian Kesenian Musik Tradisional Tong - Tong
Authors: Kurniawan Bagus Ananda , Abady Chusnul
Published: August 2020

This qualitative descriptive research method is to describe and discuss a policy of the Sumenep Regency Government to implement the Sumenep Regency Government Policy in the Context of the Development and Preservation of Traditional Music Art of Tong-Tong Madura Island, East Java Province. At the beginning of the development of traditional Tong-Tong art music which was used as a sahur patrol music was played in waking people to perform the sahur worship in the holy month of Ramadan and Calling the Dwarf who wanted to go home to his cage. In accordance with the Sumenep Regent's Regulation No. 28/2008 concerning the duties and functions of the Regional Office, the Sumenep District Youth and Sports Culture Service, has the task and function of fostering and preserving the Tong-Tong Traditional Music culture in the Sumenep district. The Tong - Tong se Madura Music Contest and the Sumenep Regency Tong - Tong Festival from 2016-2018 is in the context of fostering efforts as well as preserving the cultural heritage of the ancestors which is held regularly every year starting. The cost of conducting the Tong - Ton Traditional Arts Music Kirab Music Festival, the Tong Se Madura Music Contest and the Tong-Tong Festival is annually charged to the Sumenep Regency Regional Revenue and Expenditure Budget (APBD). The aim is to hold the Tong Tong Se Madura Music Competition and the Tong-Tong Festival every year in Sumenep Regency to improve and develop Sumenep Regency tourism promotion and marketing through the Madura tong-tong music competition.
Eksistensi Desa Agraris
Authors: Budiman Budiman , Jumansyah Jumansyah , Mulka Sry Reski , Santi Rinda Eka
Published: August 2020

The existence of an agrarian village is an integral part of sustainable regional development. The existence of Mulawarman Village as an agrarian village is the responsibility of the regional government as a dynamic / motivator of the people's aspirations, to support and protect and preserve agrarian villages. The existence of Mulawarman Village as an agrarian village is in fact still a major problem for the local government and the people in the village. This is due to the suboptimal role of the local government as a dynamic to move the aspirations of rural communities in carrying out development in the village. So that the existence of Mulawarma Village as an agrarian village is endangered.
Budaya Pluralisme dalam Penerimaan Masyarakat Desa Balun, Kabupaten Lamongan
Authors: Rozi Fatkhur , Utomo Djarot Meidi Budi
Published: August 2020

Balun Village is an interesting village to this study. The village, called the Pancasila Village, has always instilled the values ​​of pluralism in daily life and well preserved until todays. Now, Pluralism has changed shape into a culture. The SARA issues that still exist in Indonesia there is no ways to give a significant impact and influence in Balun village people's acceptance of the culture of pluralism. The phenomenological approach with in-depth interviews is used to find out the accepted (reception) of the community towards the culture of pluralism. From the results of the study, it can be seen that Balun village community acceptance of pluralism culture is very good. This acceptance is inseparable from the existence of family ties among Balun village communities. But, their perceptions are still based on reason, which can be seen in their perceptions that see pluralism as a virtue and has a lot of benefits to create a harmonious and peaceful in social life.
Penggunaan Media Sosial Terhadap Partisipasi Mahasiswa Ilmu Komunikasi UNJ dalam Menentukan Capres dan Cawapres 2019
Authors: Sekarwulan Annisa , Azzahra Assyifa Amelia , Syifafasya Nada , Safitri Dini
Published: August 2020

This study aims to describe the use of social media on the attitude of UNJ students in determining the 2019 Presidential and Vice Presidential Candidates. The method used in this study is qualitative by using an interaction model consisting of data reduction, data presentation and conclusions. Data collection techniques used in this study were interviews, observation and documentation with three informants as resource persons. The results showed that social media is not a reason in determining the choice of 2019 presidential and vice presidential candidates. That is because each individual has their own political views. Social media is used as a means of finding information about 2019 presidential and vice presidential candidates. Information that is often obtained on social media is a work program, vision and mission. Usually the information uploaded by the 2019 presidential and vice presidential candidates is easy to understand because it uses language that is easy to remember and understand. But there is some information that must be further studied. In addition, social media can become one of the effective media in accommodating the aspirations of the community if the presidential and vice presidential candidates can respond to the message conveyed by the public.
Pemetaan Meme Politik Pasca Pemilihan Umum Presiden Indonesia 2019
Authors: Soebakir Dyan Rahmiati , Pratama Bayu Indra , Hair Abdul
Published: August 2020

Peran sosial media dalam aktivitas politik tanah air semakin besar, khususnya dalam menyebarkan ide, gagasan, informasi, maupun komentar. Pemilihan umum presiden merupakan pesta demokrasi terbesar tiap lima tahunan, dimana keterlibatan masyarakat menjadi salah satu tolak ukur keberhasilannya. Konten yang dismpaikan melalui media sosial akan viral dan tidak akan mudah untuk melihat besar dampak atau efeknya. Dengan menggunakan analisis jaringan komunikasi dapat mengungkap sebaran informasi yang berkaitan pemetaan meme politik di media sosial. Pengumpulan data analisis jaringan dilakukan dengan mengunduh data interaksi di media sosial pasca debat. Percakapan yang diunduh meliputi beberapa hashtag/tagar (#) yang secara eksplisit berkaitan dengan debat. Empat tagar yang berkaitan antara lain, #debatpilpres2019 #jokowiamin #prabowosandi #pilpres2019. Pengumpulan data ini menggunakan aplikasi NODEXL. Baru kemudian dipilah yang menggunakan meme sebagai teks penyampai pesan utamanya. Dari penelitian ini didapatkan hasil akun anonim lebih dominan dalam percakapan. Meme yang paling ramai memancing perhatian adalah start-up unicorn berhasil memancing diskusi dan perdebatan di twitter. Interaksi lebih tinggi didapati kubu Prabowo. Tiga media massa dalam jaringan ini, yakni Liputan6, Indosiar, serta ConversationIDN berusaha menampilkan opini yang berimbang, yakni mentweet kedua paslon secara proporsional. Akan tetapi akun influencer, buzzer, dan BOT, lebih berperan dalam kuantitas percakapan. Interaktivitas antar akun lebih didominasi oleh retweet ketimbang reply atau komentar.
Komunikasi Partisipatoris Program Kotaku Dalam Mengurangi Kawasan Kumuh di Kampung Ketupat Samarinda Sebrang
Authors: Sugandi Sugandi , Boer Kheyene Molekandella , Alfando Johantan
Published: August 2020

The City without Slums Program (KotaKu) in Samarinda Sebrang Ketupat Village has been running for one year. Weaving villages are classified as slums. The general objective of this program is to increase access to infrastructure and basic services in urban slums to support the realization of habitable, productive and sustainable urban settlements. The research method uses qualitative with in-depth interview techniques with key informants and informants and observations. The results of the study pursed on three concepts of the approach used by the KotaKu team in communicating messages to the people of the weaving village; monologic communication, dialogic communication and multitract communication. The collaboration of these three participatory communication approaches is an effective way to change people's behavior and paradigms to change their lifestyle, habits become healthier and cleaner. The suggestion for this research is that the government should carry out continuous monitoring to see the condition after the weaving village is improved.
Evaluation of Anthropometric Parameters of Central Obesity among Professional Drivers, A Receiver Operating Characteristic (ROC) Analysis
Authors: Asif Muhammad , Aslam Muhammad , Altaf Saima , Majid Abdul , Atif Saima
Published: August 2020

Different anthropometric parameters have been proposed for assessing central obesity. The diagnostic performance of these anthropometric parameters and their ability to correctly measure central obesity for the professional community, like drivers, is questionable and needs to be assessed. The study aimed to examine the diagnostic performance of anthropometric parameters as indicators of central obesity in drivers as measured by waist circumference (WC) and to determine the best cut-off values for these parameters that would identify obese drivers. Anthropometric measurements from a cross-sectional sample of 197 professional drivers were taken under standard protocol. Receiver operating characteristics (ROC) analysis was used to examine the diagnostic performance and to determine the optimal cut-off point of each anthropometric parameter to identify centrally obese drivers. It was found that WC had a significant positive correlation with all other obesity indicators. The ROC curve analysis indicated that all the parameters analyzed had a good performance, but the waist-to-height ratio (WHtR) had a more predictive value of the area under the curve (AUC). Optimal cut-offs to identify central obesity in drivers were 0.55, 2.06, 0.95, and 25.44 for WHtR, conicity index, waist-to-hip ratio, and body mass index, respectively. These cut-off points for different indicators can be used to detect central obesity for drivers.
Effect of School Nutrition Education Program on Nutritional Practices
Authors: Gemily Syilga Cahya , Fikawati Sandra , Syafiq Ahmad
Published: August 2020

Gerakan Nusantara is a nutrition education program that aims to change the nutrition knowledge, attitudes, and practices of elementary school children in Indonesia. The program was implemented in 2015–2018 in Jakarta, Bandung, Surabaya, Makassar, Medan, Yogyakarta, Pontianak, East Nusa Tenggara, Pekanbaru, Padang, Jambi, and Sorong. The present study sought to determine the effects of Gerakan Nusantara on the nutrition practices of school-aged children and describe the extent of changes in each nutrition practice component covered by the program. This study used secondary data on Nutrition and Health Knowledge, Attitudes, and Practices studies collected from students participating in the program and involved 6132 school children. The seven nutrition practice components studied were consumption of staple foods, plant protein, animal protein, vegetables, and fruits; milk drinking; and exercise. Significant improvements in fruit consumption and exercise were noted in 2015; all variables improved in 2016; significant changes in the consumption of staple food and plant protein and exercise were recorded in 2017; and significant improvements in the consumption of vegetables, plant protein, and animal protein and milk drinking were noted in 2018. Significant differences in nutrition practices before and after program implementation were noted in each year. Overall, the results demonstrated that Gerakan Nusantara successfully improved the nutrition practices of elementary school children.
Effect of Education through WhatsApp Media in Changing of Smoking Behavior among Senior High School Students
Authors: Yusriani Yusriani , Acob Joel Rey U.
Published: August 2020

Teenagers, who are considerably susceptible to smoking, must be educated to prevent smoking behavior that can cause health problems and even death. The aim of this study was to assess the effect of education through social media such as WhatsApp in the modification of smoking behaviors among senior high school students in Pangkep District, Indonesia. It employed a quasi-experimental, pretest-posttest-only control group design. The experimental group received education in the use of WhatsApp social media, while the control group was provided with leaflets. Data were collected through observation and interviews with a total of 180 students in both groups, with 90 students in each. Data analysis used a paired sample t-test and an independent sample t-test. The study suggested that disseminating health information through WhatsApp media about the dangers of teenage smoking was more effective than leaflets in changing student behavior.
Prevention and Control of Type 2 Diabetes Mellitus in Indonesia through the Modification of Physiological Factors and Physical Activities
Authors: Simbolon Demsa , Siregar Afriyana , Talib Ruzita ABD
Published: August 2020

Type 2 diabetes mellitus (T2DM) is the sixth highest cause of death in Indonesia. Thus, it must be prevented and overcome with appropriate management. This study aimed to determine the contribution of physiological factors and physical activities to the incidence of T2DM. The study used a cohort retrospective design using secondary data from the Indonesian Family Life Survey (IFLS) from 2007 to 2014, which included a sample of 14,517 people involved for more than 20 years. Data analysis was performed using multiple logistic regressions. The results revealed a 3.8% incidence of T2DM in Indonesia. Record of hypertension risk increased the likelihood of T2DM by 1.7 times compared to without hypertension. A normal body mass index (BMI) increased the risk by 2.2 times, a higher BMI at 5.5 times, and BMI whose risk obesity was 7 times had greater likelihood of having T2DM compared with respondents with a thin BMI. After controlling for sex, age, marital status, record of parents’ DM, residence, employment, and education, results also indicated that people with less active physical activity were likely to have T2DM compared to those who were very active. Controlling blood pressure, maintaining a normal BMI, and increasing physical activity since adolescence can prevent T2DM.
Relationship between Spirituality and Acceptance of Illness Level in Bipolar Patients
Authors: Atsira Olga Putri , Yuliati Erikavitri , Atika Atika , Abdurachman Abdurachman , Maramis Margarita Maria
Published: August 2020

Bipolar disorder is a chronic mental condition that affects patients’ quality of life. The management process is affected by acceptance of illness. The ability to accept the illness is related to the spirituality level which is something that is held strongly by Indonesian people. There has been very little research related to the relationship between spirituality with bipolar disorder. This study aimed to analyze relationship between spirituality levels with acceptance of illness in patients with bipolar disorder. This study is a correlational study using questionnaire from bipolar disorder patients contacted through Harmony in Diversity online community as a sample. Samples were taken in total sampling according to inclusion and exclusion criteria. The numbers of samples were 30 samples. Calculation of the correlation between acceptance of illness in patients with bipolar disorder with vertical spirituality (RWB) (p = 0.050) (r = 0.306), horizontal spirituality (EWB) (p = 0.001) (r = 0.556), and general spirituality (SWB) (p = 0.007) (r = 0.444). There is a significant positive correlation between acceptance of illness in patients with bipolar disorder and general spirituality with a more significant horizontal dimension compared to vertical dimension.
Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)
Authors: Hurley Deirdre , Jeffares Isabelle , Hall Amanda M , Keogh Alison , Toomey Elaine , McArdle Danielle , McDonough Suzanne M , Guerin Suzanne , Segurado Ricardo , Matthews James
Published: August 2020

Background: The Self-management of Osteoarthritis (OA) and Low back pain (LBP) through Activity and Skills (SOLAS) theory-driven group-based complex intervention was developed primarily for the evaluation of its acceptability to patients and physiotherapists and the feasibility of trial procedures, to inform the potential for a definitive trial. Methods: This assessor-blinded multicentre two-arm parallel cluster randomised controlled feasibility trial compared the SOLAS intervention to usual individual physiotherapy (UP; pragmatic control group). Patients with OA of the hip, knee, lumbar spine and/or chronic LBP were recruited in primary care physiotherapy clinics (i.e. clusters) in Dublin, Ireland between September 2014 and November 2015. The primary feasibility objectives were evaluated using quantitative methods and individual telephone interviews with purposive samples of participants and physiotherapists. A range of secondary outcomes were collected at baseline, 6 weeks (behaviour change only), 2 months and 6 months to explore the preliminary effects of the intervention. Analysis was by intention-to-treat according to participants’ cluster allocation and involved descriptive analysis of the quantitative data and inductive thematic analysis of the qualitative interviews. A linear mixed model was used to contrast change over time in participant secondary outcomes between treatment arms, while adjusting for study waves and clusters. Results: 14 clusters were recruited (7 per trial arm), each cluster participated in two waves of recruitment, with the average cluster size below the target of six participants (Intervention: mean (SD) =4.92 (1.31), range 2-7; UP: mean (SD) =5.08 (2.43), range 1-9). 120 participants (83.3% of n=144 expected) were recruited (Intervention n=59; UP n=61), with follow up data obtained from 80.8% (n=97) at 6 weeks, 84.2% (n=101) at 2 months and 71.7% (n=86) at 6 months. Most participants received treatment as allocated (Intervention n=49; UP n=54). The qualitative interviews (12 participants; 10 PTs) found the Intervention and trial procedures acceptable and appropriate, with minimal feasible adaptations required. Linear mixed methods showed improvements in most secondary outcomes at 2 and 6 months with small between group effects.Conclusions: While the SOLAS intervention and trial procedures were acceptable to participants and PTs, the recruitment of enough participants is the biggest obstacle to a definitive trial.Trial Registration: ISRCTN Registry, ISRCTN49875385, Registered 26 March 2014. https://doi.org/10.1186/ISRCTN49875385
Integrated Analysis of lncRNA, miRNA and mRNA Reveals Novel Insights into the Fertility Regulation of Large White Sows
Authors: Hu Huiyan , Jia Qing , Xi Jianzhong , Zhou Bo , Li Zhiqiang
Published: August 2020

Background: Improving sow fertility is extremely important as it can lead to increased reproductive efficiency and thus profitability for swine producers. There are considerable differences in fertility rates among individual animals, but the underlying molecular mechanisms remain unclear. In this study, by using different types of RNA libraries, we investigated the complete transcriptome of ovarian tissue during the luteal (L) and follicular (F) phases of the estrous cycle in Large White pigs withhigh (H) and low (L) fecundity, and performed a comprehensive analysis of long noncoding RNAs (lncRNAs), mRNAs and micro RNAs (miRNAs) from 16 samples by combining RNA sequencing (RNA-seq) with bioinformatics.Results: In total, 24,447 lncRNAs, 27,370 mRNAs, and 216 known miRNAs were identified in ovarian tissues. The genomic features of lncRNAs, such as length distribution and number of exons, were further analyzed. We selected a threshold of P<0.05 and |log2 (fold change)| ≥ 1 to obtain the differentially expressed lncRNAs, miRNAs and mRNAs by pairwise comparison (LH vs. LL, FH vs. FL).Bioinformatics analysis of these differentially expressed RNAs revealed multiple significantly enriched pathways (P< 0.05) that were closely involved in the reproductive process, such as ovarian steroidogenesis, lysosome, steroid biosynthesis, and the estrogen and GnRH signaling pathways. Moreover, bioinformatics screening of differentially expressed miRNAs that share common miRNA response elements (MREs) with lncRNAs and their downstream mRNA targets were performed. Finally, we constructed lncRNA–miRNA–mRNA regulation networks. The key genes in these networks were verified by Reverse Transcription Real-time Quantitative PCR (RT-qRCR), which were consistent with the results from RNA-Seq data.Conclusions: These results provide further insights into the fertility of pigs andcan contribute to further experimental investigation of the functions of these genes.
Nausea, vomiting and poor appetite during pregnancy and adverse birth outcomes in rural Nepal: an observational cohort study
Authors: Wallin Amanda Regodón , Tielsch James M , Khatry Subarna K , Mullany Luke C , Englund Janet A , Chu Helen , LeClerq Steven C , Katz Joanne
Published: August 2020

Background Nausea and vomiting are experienced by a majority of pregnant women worldwide. Previous studies have yielded conflicting results regarding their impact on birth outcomes and few studies have examined this relationship in settings with limited resources. We aimed to determine the effect of nausea, vomiting and poor appetite during pregnancy on birth outcomes in rural Nepal.Methods Observational cohort study using data collected in two randomized, community-based trials to assess the effect of influenza immunization during pregnancy on reproductive and respiratory outcomes among pregnant women and their offspring. Pregnant women in Sarlahi District, Nepal were recruited from 2011-2013. Exposure was defined as nausea, vomiting or poor appetite at any point during pregnancy and by trimester; symptoms were recorded monthly throughout pregnancy. Adverse outcomes were low birth weight (LBW), preterm birth and small for gestational age (SGA). Adjusted relative risks (aRR) with 95% CIs is reported from Poisson regressions with robust variance.Results Among 3,623 pregnant women, the cumulative incidence of nausea, vomiting or poor appetite was 49.5% (n=1793) throughout pregnancy and 60.6% (n=731) in the first trimester. Significantly higher aRRs of LBW and SGA were observed among women experiencing symptoms during pregnancy as compared to symptom free women (LBW: aRR 1.20; 95% CI 1.05 1.28; SGA: aRR 1.16; 95% CI 1.05 1.28). Symptoms in the first trimester were not significantly associated with any of the outcomes. In the second trimester, we observed significantly higher aRRs for LBW and SGA (LBW: aRR 1.17; 95% CI 1.01 1.36; SGA: aRR 1.16; 95% CI 1.05 1.29) and a significantly lower aRR for preterm birth (aRR 0.75; 95% CI 0.59 0.96). In the third trimester, we observed significantly higher aRRs for LBW and SGA (LBW: aRR 1.20; 95% CI 1.01 1.43; SGA: aRR 1.14; 95% CI 1.01 1.29).Conclusions Symptoms of nausea, vomiting or poor appetite during pregnancy are associated with LBW, SGA and preterm birth in a setting with limited resources, especially beyond the first trimester.Trial registration Prospectively registered at ClinicalTrials.gov on Dec 17, 2009 (NCT01034254)
Identification and characteristics of a novel cecropin from the armyworm, Mythimna separata
Authors: Lian Kaiqi , Zhang Mingliang , Liang Xiuli , Zhou Lingling , Shi Zhiqi , Tang Yajie , Wang Xueping , Song Yuwei , Zhang Yuanchen
Published: August 2020

Background: The recent emergence of antibiotic-resistant strains of bacteria has increased the need to develop effective alternatives to antibiotics. Antimicrobial peptides have been considered as a promising product with several advantages.Results: In this present study, we identified a novel cecropin from the armyworm, Mythimna separata (armyworm cecropin 1, AC-1) by transcriptome sequencing and multi-sequence alignment analysis. The AC-1 precursor comprised 63 amino acid residues, containing a conserved cleavage site of the signal peptide, Ala23-Pro24, while the mature AC-1 included 39 amino acid residues. Chemically synthesized AC-1 exhibited low hemolytic activity against chicken red blood cells, low cytotoxicity against swine testis cells, and effective antimicrobial activity against Salmonella, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa. Its antimicrobial activity against Salmonella remained after incubation for 1 h at 100 °C or in 250 mM NaCl, KCl, or MgCl2 solution, implying good thermal- and salt-resistant stabilities. The bactericidal effect of AC-1 on E. coli gradually increased with increasing AC-1 concentration, resulting in deformation, severe edema, cytolysis, cell membrane damage, and reducing intracellular electron density. Additionally, recombinant AC-1 protein expressed in E. coli was digested by enterokinase protease to obtain AC-1, which showed similar antimicrobial activity against E. coli to chemically synthesized AC-1.Conclusions: This study identified a novel antimicrobial peptide that may represent a potential alternative to antibiotics.
Dog importation and changes in canine intestinal nematode prevalence in Colorado 2013-2017
Authors: Drake Jason , Parrish Rudolph
Published: August 2020

Background: Animal rescue and animal welfare organizations are relocating thousands of dogs per year following natural disasters and in attempts to provide greater adoption opportunities. Many dogs are sourced from the southeastern USA, which historically has a high prevalence rate for many parasites and parasitic diseases. The Colorado Department of Agriculture Pet Animal Care Facilities Act (PACFA) requires animal shelters and animal welfare organizations to report annually a variety of statistics including the numbers of dogs imported into Colorado from out of state. The Companion Animal Parasite Council (CAPC) provides data nationally, down to the state and county level, on a variety of common parasitic and vector borne diseases. These data make it possible to track changes in parasite prevalence over several years. Methods: Test results for canine roundworm, hookworm and whipworm were collected from the CAPC maps for 2013–2017. Dog importation data for 2014–2017 was collected from PACFA reports. For evaluation of the statistical significance of prevalence changes when comparing 2013 to 2017, 2 × 2 contingency tables were constructed with both positive and negative test results for each year and the data assessed using Chi-square tests to determine if the 2017 prevalence was significantly different than the 2013 prevalence for roundworm, hookworm and whipworm.Results: Significant increases in intestinal nematode prevalence occurred in Colorado from 2013 to 2017. The prevalence of canine roundworm rose 35.60%, the prevalence of canine hookworm rose 137.33% and the prevalence of canine whipworm rose 63.68%. From 2014 to 2017, over 114,000 dogs were transported into Colorado from out-of-state, by more than 130 animal shelters and rescue organizations. Three of the larger organizations reported that the majority of their dogs were obtained from New Mexico, Texas and Oklahoma. Texas and Oklahoma have historically much higher parasite prevalence than Colorado. Conclusions: Veterinarians in areas with historically low parasite prevalence where dogs from high parasite prevalence areas are arriving for adoption may need to reevaluate their recommendations regarding fecal examination and deworming frequencies as historic levels of intestinal parasite infection may no longer be accurate assessments of future infection risks.
Multi-tissue transcriptome analysis using hybrid-sequencing reveals potential genes and biological pathways associated with azadirachtin A biosynthesis in neem (Azadirachta indica)
Authors: Wang Huiyan , Wang Ning , Huo Yixin
Published: August 2020

Background: Azadirachtin A is a triterpenoid from neem tree exhibiting excellent activities against over 600 insect species in agriculture. The production of azadirachtin A depends on extraction from neem tissues, which is not an eco-friendly and sustainable process. The low yield and discontinuous supply of azadirachtin A impedes further applications. The biosynthetic pathway of azadirachtin A is still unknown and is the focus of our study. Results: We attempted to explore azadirachtin A biosynthetic pathway and identified the key genes involved by analyzing transcriptome data from five neem tissues through the hybrid-sequencing (Illumina HiSeq and Pacific Biosciences Single Molecule Real-Time (SMRT)) approach. Candidates were first screened by comparing the expression levels between the five tissues. After phylogenetic analysis, domain prediction, and molecular docking studies, 22 candidates encoding 2,3-oxidosqualene cyclase (OSC), alcohol dehydrogenase, cytochrome P450 (CYP450), acyltransferase, and esterase were proposed to be potential genes involved in azadirachtin A biosynthesis. Among them, two unigenes encoding homologs of MaOSC1 and MaCYP71CD2 were identified. A unigene encoding the complete homolog of MaCYP71BQ5 was reported. Accuracy of the assembly was verified by quantitative real-time PCR (qRT-PCR) and full-length PCR cloning. Conclusions: By integrating and analyzing transcriptome data from hybrid-seq technology, 22 differentially expressed genes (DEGs) were finally selected as candidates involved in azadirachtin A pathway. The obtained reliable and accurate sequencing data provided important novel information for understanding neem genome. Our data shed new light on understanding the biosynthesis of other triterpenoids in neem trees and provides a reference for exploring other valuable natural product biosynthesis in plants.
Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy
Authors: Kim Jae Yeon , Park Sohae , Lee Hyun-Jung , Lew Helen , Kim Gi Jin
Published: August 2020

Background: Placenta-derived mesenchymal stem cells (PD-MSCs) have unique immunomodulatory properties. Phosphatase of regenerating liver-1 (PRL-1) regulates the self-renewal ability of stem cells and promotes proliferation. Graves’ ophthalmopathy (GO) is an autoimmune inflammatory disease of the orbit and is characterized by increased orbital levels of adipose tissue. Here, we evaluated the therapeutic mechanism for regulation of adipogenesis by PRL-1-overexpressing PD-MSCs (PD-MSCsPRL-1, PRL-1+) in orbital fibroblast (OF) with GO patients.Methods: Primary OFs were isolated from orbital adipose tissue specimens from GO patients. After maturation as adipogenic differentiation, normal and GO-derived OFs were cocultured with naïve and PD-MSCsPRL-1. We analyzed the protein levels of adipogenesis markers and their signaling pathways in OF from GO patients. Results: The characteristics of PD-MSCsPRL-1 were similar to those of naïve cells. OFs from GO patients induced adipocyte differentiation and had significantly decreased a lipid accumulation after coculture with PD-MSCsPRL-1 compared to naïve. The mRNA and protein expression of adipogenic markers was decreased in PD-MSCsPRL-1. Insulin-like growth factor-binding proteins (IGFBPs) secreting PD-MSCsPRL-1 downregulated the phosphorylated PI3K/AKT/mTOR expression in OFs from GO patients. Interestingly, IGFBP2, -4, and -7 expression in PD-MSCsPRL-1, which was mediated by integrin alpha 4 (ITGA4) and beta 7 (ITGB7), was higher than that in naïve cells and upregulated phosphorylated FAK downstream factors.Conclusion: In summary, IGFBPs secreting PD-MSCPRL-1 inhibit adipogenesis in OFs from GO patients by upregulating phosphorylated FAK, providing a novel therapeutic strategy using functionally enhanced MSCs to treat degenerative diseases.