bluuebunny/crossref_metadata_2025 huggingface dataset:
PERSEPSI MAHASISWA ILMU KOMUNIKASI UNIVERSITAS TIDAR PADA KINERJA PEMERINTAH
Authors: Syahputra M. Irsyad , Istiqomah Ita , Shanti Ratih Dwi Nur , Nada M Allisa Qotrhun , Gusti Setiadi M. Faisal , Nugraha Joko Tri
Published: January 2025

Penelitian ini bertujuan untuk menggambarkan kondisi atau fenomena saat ini secara numerik dan menganalisis hubungan antarvariabel secara terukur. Penelitian ini menggunakan metode kuantitatif dengan pendekatan survei untuk menganalisis persepsi mahasiswa Ilmu Komunikasi Universitas Tidar terhadap peran pemerintah dalam mendukung pendidikan tinggi. Survei dilakukan dengan menyebarkan kuesioner yang mengukur variabel penelitian melalui skala Likert lima tingkat. Populasi penelitian adalah mahasiswa Ilmu Komunikasi Universitas Tidar, dengan teknik sampling yang memastikan representasi populasi. Analisis data dilakukan menggunakan Microsoft Excel dan SPSS, mencakup analisis deskriptif berupa frekuensi, persentase, rata-rata, dan deviasi standar. Hasil penelitian menunjukkan mayoritas responden memiliki pandangan positif terhadap peran pemerintah, meskipun terdapat beberapa aspek yang masih memerlukan perhatian. Responden menyatakan setuju bahwa pemerintah memberikan dukungan untuk akses pendidikan tinggi (66%) dan responsif terhadap isu kesejahteraan mahasiswa (58%). Namun, dukungan terhadap kesehatan mental mahasiswa dinilai kurang memadai (42% tidak setuju). Penelitian ini memberikan kontribusi dalam mengevaluasi efektivitas kebijakan pemerintah terkait pendidikan tinggi dan isu kesejahteraan mahasiswa. Hasil ini diharapkan menjadi masukan bagi pemerintah untuk meningkatkan kebijakan yang mendukung kebutuhan mahasiswa secara holistik.
Kata Kunci : Persepsi Mahasiswa, Media Sosial , Kinerja Pemerintah
EFEKTIVITAS PEMASARAN DIGITAL SEBAGAI SARANA PROMOSI OLEH MAHASISWA
Authors: Yuanichi Sakura Chiva Kamisah , Wiji Sejati Diana , Setyaningrum Intan Tri , Kurniawan Mardiana Putri , Palinngih Rahmatia Wahyu , Nugraha Joko Tri
Published: January 2025

Penelitian ini bertujuan untuk mengeksplorasi dan memahami efektivitas pemasaran digital sebagai sarana promosi yang digunakan oleh mahasiswa. Dengan menggunakan pendekatan kuantitatif, studi ini menggali pengalaman dan perspektif mahasiswa tentang bagaimana pemasaran digital dimanfaatkan untuk mempromosikan kegiatan, produk, atau jasa mereka, serta dampaknya terhadap efektivitas promosi. Data dikumpulkan melalui pengisian kuesioner mendalam dengan 60 partisipan yang dipilih berdasarkan kriteria tertentu, yaitu mahasiswa yang aktif melakukan pemasaran digital untuk promosi dalam rentang usia 17-21 tahun. Hasil penelitian menunjukkan bahwa pemasaran digital memainkan peran penting dalam meningkatkan jangkauan dan efektivitas promosi, namun juga menghadirkan tantangan seperti persaingan konten dan kebutuhan untuk mengelola citra secara konsisten. Penelitian ini mengungkapkan bahwa strategi pemasaran digital yang terencana dengan baik dapat membantu mahasiswa mencapai tujuan promosi mereka, sementara penggunaan yang kurang terencana dapat membatasi hasil yang diharapkan. Dengan demikian, penelitian ini memberikan wawasan baru mengenai pentingnya pemahaman tentang pemasaran digital dan strategi promosi dalam mendukung aktivitas mahasiswa.
Kata Kunci: Pemasaran Digital, Promosi, Mahasiswa
PENGARUH TINGKAT KESADARAN TERHADAP PENGAMBILAN KEPUTUSAN DALAM INTERPERSONAL
Authors: Khasanah Nur , Maliihah Juniar Dwi Wardah , Pesudo Stacey Angellina , Ramadhani Hani , Aji Bayu Kirtya , Nugraha Joko Tri
Published: January 2025

Penelitian ini bertujuan untuk mengkaji pengaruh tingkat kesadaran terhadap pengambilan keputusan, khususnya dalam situasi konflik, menggunakan metode kuantitatif dengan pendekatan survei. Data dikumpulkan melalui kuesioner online yang disebarkan kepada 50 responden pelajar, dengan mayoritas responden perempuan (86%). Analisis data dilakukan menggunakan Microsoft Excel dan SPSS, melibatkan analisis deskriptif dan inferensial untuk menguji hubungan antara tingkat kesadaran diri dan pengambilan keputusan. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki tingkat kesadaran yang tinggi terhadap perasaan mereka (92%) dan sering mempertimbangkan dampak keputusan mereka terhadap orang lain (74%). Lebih dari separuh responden juga mampu mengenali penyebab emosinya saat marah atau kecewa (74%) dan mengambil waktu untuk berpikir sebelum bereaksi (74%). Selain itu, tingkat kesadaran diri secara signifikan membantu responden dalam menyelesaikan konflik secara konstruktif (72%). Simpulan, pentingnya kesadaran diri sebagai faktor yang mendukung pengambilan keputusan yang bijaksana dan konstruktif dalam situasi konflik. Implikasi penelitian mencakup pentingnya pelatihan kesadaran diri untuk meningkatkan kualitas pengambilan keputusan, khususnya di kalangan pelajar.
Kata Kunci : Kesadaran Diri, Pengambilan Keputusan, Hubungan Interpersonal
Strength Training can Modulate Urinary Adipokine Levels in Healthy Young Males
Authors: Faria Marcelo Henrique Salviano de , Barroso Lucélia Scarabeli Silva , Souza-Gomes Antonio Felipe , Barros João Luís Vieira Monteiro de , Kakehasi Adriana Maria , Vieira Erica Leandro Marciano , Silva Ana Cristina Simões e , Nunes-Silva Albená
Published: January 2025

Adipose tissue stores energy in fat-rich adipocytes, which can produce and release several adipokines and modulate body metabolism. Exercise may induce adipokine production in adipocytes; however, the relationship between the two remains unclear. Few studies have shown the relationship between adipokines and strength training. Thus, we aimed to evaluate the acute and chronic effects of strength training (ST) on urinary adiponectin, leptin, and resistin levels. Twelve untrained young men (23.42 ± 2.67 years) were included in this study. Body composition was evaluated at baseline and after completing of the training protocol using densitometry. Training protocol consisted of three exercises with three sets of 65% of one-repetition maximum (1MR) with a pause of 90 s between sets, each exercise lasting 5 s (2 s concentric / 3 s eccentric). The sessions were carried out three times a week for 10 weeks. Urine was collected during the pre- and post-training in the first and 30th session. Adipokine levels were determined by ELISA. Urinary levels of leptin acutely increased after the first ST session, and after the last ST session. Chronic changes in the leptin levels were also found when comparing the values before the last ST and before the first ST session. Urinary adiponectin levels changed in the comparison of values before and after the last session. There was a significant increase in the adiponectin levels when comparing values after the first and last ST sessions. The levels of resistin chronically increased. Strength training can induce acute and chronic changes in urinary levels of adipokines.
Pengembangan Media Pembelajaran Berbasis Powtoon Pada Mata Pelajaran IPAS Kelas Iv Di SDN Sudimara 11 Ciledug
Authors:   Universitas Muhammadiyah Jakarta, Ahda Sabila Syahrani , Hayun Muhammad ,   Universitas Muhammadiyah Jakarta
Published: January 2025

Berdasarkan latar belakang permasalah pada penelitian ini adalah media pembelajaran masih kurang maksimal karna penggunaan teknologi dalam proses pembelajaran yang menyebabkan siswa mengalami kesulitan dalam belajar yang mengakibatkan siswa kurang meningkatkan minat belajar siswa dalam proses pembelajaran IPAS. Adapun tujuan penelitian ini yaitu untuk mengetahui kelayakan media pembelajaran, mengetahui efektivitas media pembelajaran Powtoon dalam mata pelajaran IPAS, mengetahui respon pendidik dan siswa pada mata pelajaran IPAS. Metode yang digunakan dalam penelitian yaitu research and development dengan model Thiagarajan atau disebut dengan 4D yang terdiri dari 4 tahapan utama yakni Define (Pendefinisian), Design (Perancangan), Develop (Pengembangan) dan Disseminate (Penyebaran). Metode Teknik pengumpulan data yang digunakan dalam penelitian yaitu dengan memberikan instrumen penelitian berupa angket kepada ahli materi, ahli Bahasa, ahli media, dan uji coba respon siswa. Hasil Penelitian ini yang didapatkan melalui instrumen penelitian yang diberikan oleh para ahli. Ahli Materi memberikan nilai sebesar 86,67 % termasuk kategori sangat valid, ahli Bahasa memberikan nilai sebesar 83,3% termasuk kategori valid, ahli Media memberikan nilai sebesar 100% termasuk kategori sangat valid, untuk uji coba kelompok besar sebesar 97% termasuk kategori sangat valid dan uji kelompok kecil sebesar 96% termasuk kategori sangat valid. Berdasarkan hasil penilaian dari ketiga ahli dan uji coba respon siswa, maka media pembelajaran berbasis Powtoon pada mata pelajaran IPAS kelas IV layak digunakan dalam proses pembelajaran berlangsung.
Naltrexone Utilization Along Its Dosing Spectrum - A Literature Review
Authors: Gray Courtney
Published: January 2025

Naltrexone, a widely recognized opioid receptor antagonist, has been primarily used at standard doses of 50–100 mg daily to treat opioid and alcohol use disorders. Recent studies, however, reveal its versatility across a broader dosing spectrum. This review examines the therapeutic effects and safety profiles of naltrexone across three dosing strategies: standard doses for substance use disorders, low-dose naltrexone (LDN, 1–5 mg/day) for chronic pain and autoimmune diseases, and ultra-low-dose naltrexone (ULDN, microgram levels) as a complement to opioid therapy. However, naltrexone’s role in reducing opioid misuse among those with a history of dependency remains limited. Our results serve to highlight naltrexone’s expanding clinical applications and highlights the need for further research to optimize its use across diverse dosing regimens and conditions.
Advancements in Tubular Solar Stills: Design, Efficiency, and Applications
Authors: Al-Omari Sadiq B. T.
Published: January 2025

Recently, tubular solar stills are being intensively studied as a feasible and effective technique for solar desalination. This innovative technological framework is fundamentally based on the sustainable and eco-friendly paradigm that promotes environmental consideration and resource efficiency. This comprehensive review has highlighted the series of recent improvements in essential design innovations, the performance of advanced materials, and the application of efficiency optimization techniques. For instance, the use of Phase Change Materials (PCMs), nanocomposites, multi-staging boiling systems, and implementation of structural modifications such as cascading tubular designs and various geometrical alterations have underlined the crucial importance of enhancing thermal efficiency and maximizing daily water productivity. The results obtained from multiple studies show that these pivotal innovations have the potential to be highly disseminated across different regions, thus making significant strides towards overcoming the persistent issue of freshwater scarcity. Additionally, they can be applied in a scalable and practical approach. Future directions point towards the integration of artificial intelligence and the use of hybrid renewable energy systems to further optimize performance, adaptability, and efficiency, allowing for an insightful approach to addressing water shortages effectively.
Analisis SWOT dalam Menentukan Strategi Pemasaran (Studi Kasus Mie Gacoan Antasari Bandar Lampung)
Authors: Kulsum Umi , Tanti Tanti , Arroisah Ulfia Anis , Sanjaya Vicky F
Published: January 2025

This study analyzes the marketing strategy of Mie Gacoan using the SWOT (Strengths, Weaknesses, Opportunities, Threats) method to formulate relevant competitive strategies. Through the IFE (Internal Factor Evaluation) matrix, strengths such as unique menu variations, competitive pricing, and strategic locations were identified. Meanwhile, weaknesses include limited production capacity and dependency on local raw materials. The EFE (External Factor Evaluation) matrix highlights major opportunities, including the fast-food consumption trend and the growth of digital platforms, as well as threats such as intense competition and raw material price fluctuations. The analysis results indicate that Mie Gacoan is positioned in Quadrant I, suggesting the potential to adopt an aggressive growth strategy. This strategy includes menu innovation, market expansion through digital platforms, and increasing production capacity. With a total IFE score of 3.80 and EFE score of 4.20, Mie Gacoan has significant opportunities to enhance its competitiveness in the fast-food market.
Strategi Pengembangan SDM pada UMKM Kuliner di Kota Mataram Nusa Tenggara Barat
Authors: Hamdi Subhan , Kartika Misya , Putra Danu Pratama
Published: January 2025

This study aims to analyze the strategy of human resource development (HR) in Micro, Small, and Medium Enterprises (MSMEs) in the culinary sector in Mataram City, West Nusa Tenggara. The main focus of this study is on efforts to improve workforce competence, training management, and adaptation strategies to market and technology dynamics. A qualitative approach is used with data collection techniques in the form of in-depth interviews, observations, and document studies. The results of the study show that effective human resource development involves continuous training, strengthening managerial skills, and the use of digital technology to improve operational efficiency. In addition, collaboration with the government and the private sector is a key factor in increasing the competitiveness of culinary MSMEs in Mataram. This study provides recommendations for stakeholders to integrate human resource development strategies in long-term plans to support sustainable local economic growth.
Smart Harvests: Cultivating Climate Resilience
Authors:   Leaves and Dew Publication, Kumar Sanjeev , Meena Babu Lal , Om Hari , Kumar Sudhir , Meena Vijendra Kumar
Published: January 2025

Smart Harvests: Cultivating Climate Resilience is a comprehensive guide designed to equip farmers, researchers, policymakers, and agriculture enthusiasts with the tools needed to adapt to climate challenges. The book starts by explaining the basics of climate-smart agriculture and the impacts of climate change on crops, laying the foundation for practical solutions. It provides actionable insights into choosing resilient crops, adopting innovative farming techniques, and managing water effectively to mitigate risks. With a focus on precision farming, readers learn how technology can optimize yields and enhance efficiency. Key topics include improving soil health, storing carbon, adapting crop rotations, and breeding climate-resilient seeds. The book also emphasizes the value of community collaboration in spreading sustainable practices. Looking to the future, it highlights strategies for building food systems that are productive and environmentally friendly, ensuring a sustainable approach to feeding the world. This guide serves as a roadmap for thriving in an unpredictable climate while promoting sustainable agricultural growth.
The Impact Of Short Video Content And Social Media Influencers On Digital Marketing Success: A Systematic Literature Review Of Smartphone Usage
Authors: Islam Md Mujahidul , Kabir Mohammad Anowarul
Published: January 2025

This study explores the transformative role of short video marketing in modern digital campaigns, with a focus on its ability to engage audiences, enhance brand visibility, and foster consumer trust. By systematically reviewing 78 peer-reviewed articles published between 2018 and 2024, this research synthesizes insights into the dynamics of short video platforms like TikTok, Instagram Reels, and YouTube Shorts. The study highlights the effectiveness of algorithmic personalization in delivering tailored content, driving a 60% increase in engagement rates compared to non-personalized campaigns. It also emphasizes the pivotal role of influencers, particularly micro-influencers, in connecting with niche audiences and fostering trust through relatability and authenticity. Key performance metrics such as retention rates, shares, and real-time analytics are identified as critical tools for evaluating campaign success, while emerging trends like augmented reality, live shopping, and interactive advertisements demonstrate the innovative potential of short video marketing. This review also identifies significant research gaps, including the long-term impact of short video campaigns, ethical considerations in data-driven marketing, and strategies for cross-platform content optimization. By providing a comprehensive understanding of the current landscape and future directions, this study offers valuable insights for researchers and practitioners seeking to navigate the evolving domain of short video marketing effectively and ethically.
ASSOCIATION OF ORAL HYGIENE PRACTICES AND PERIODONTAL HEALTH IN FEMALES WITH RESPECT TO THE TRIMESTER OF PREGNANCY
Authors: Sheikh Hina Rafiq , Bhatti Farwa Shabir , Toor Yahya Zia Ahmed , Shakoor Asma , Anwar Ayesha , Sajwar Zainab , Butt Hira
Published: January 2025

Background: Periodontal health is significantly associated and impacted by pregnancy. It has been reported previously that periodontal health of women is influenced differently as the pregnancy progresses. Oral hygiene maintenance can have an influence on the extent and nature of influence of pregnancy on the periodontal health. The deterioration of oral health as a result of hormonal shifts that ensues during pregnancy can be slowed, reversed and even avoided by maintaining meticulous oral hygiene.
Objective: To find the association between oral hygiene practices and periodontal health in females with respect to the trimester of pregnancy.
Methods: A cross-sectional comparative study was conducted on 44 pregnant females in Sharif Medical and Dental College, Lahore. Ethical approval was obtained, and data was collected using a specialized proforma for recording demographic information and oral hygiene practices. CPTIN was used for assessing the periodontal health.
Results: A non-significant association between frequency of brushing and periodontal health of women was seen in their first trimester (p=0.455) and third trimester (p=0.447) while the association between frequency of brushing and periodontal health of women in their second trimester was significant (p=0.029).
Conclusion: Oral hygiene maintenance had a significant impact on the periodontal health of pregnant women. Those who maintained good oral hygiene practices and brushed their teeth twice daily had a healthier periodontium and lower calculus deposition. Women in their second trimester who brushed twice daily had more periodontal pockets as compared to those who brushed once. In the first and third trimester no periodontal pockets were seen in females who maintained good oral hygiene practices and brushed twice daily.
Reverse Teacher Questioning Strategy to Enlarge ZPD! ---- A New Approach to Improve Differentiated Classroom
Authors: Feng Yunuo
Published: January 2025

Differentiated instruction has always been a major challenge for educators, and how to balance the learning tasks of diverse levels of learners is at the top of the list. This research is based on further exploration of the ZPD theory through quantitative analysis of the research methodology and in-depth one-on-one interviews with 12 students from an international high school in Shanghai, China. The research found that learners were not offended by tiered tasks itself, but they were offended by being assigned different tiers of tasks by their teachers and expected that they would have the choice of different learning tasks. For learning tasks, learners prefer more challenging tasks, and the reverse teacher questioning strategy, i.e. ‘hard-to-easy’ teacher questioning strategy, can effectively help learners to develop the ability to solve complex tasks. This constructed learning ability effectively teaches learners to ask questions, understand questions, analyse questions, and solve them. This ability can contribute to expanding the ZPD of learners with different abilities and narrowing the ability gap in a mixed-ability classroom.
Social Gender Performance in the Algorithmic Age: The Discipline of Emotional Labor and the Negotiation of Digital Identities in Chinese "She Variety" on TV
Authors: Ma Ying
Published: January 2025

Drawing upon social gender performance theory, this paper investigates the discipline of emotional labor and the negotiation of digital identities in Chinese "She Variety" on TV within the context of the algorithmic age. "She Variety," as an emerging genre of television programming, not only showcases the diverse roles and subjective consciousness of women in contemporary society but also reflects the multiple influences of algorithmic logic, commercial interests, and traditional gender norms on the construction of female images. Through textual analysis of several representative "She Variety" programs (such as Sisters Who Make Waves) and examination of online comments, this study finds that female participants engage in complex emotional labor, demonstrating both conformity to traditional gender roles and challenges to patriarchal norms. Simultaneously, they actively negotiate their identities in the digital media environment, striving to construct autonomous and diverse digital selves. The paper argues that in the algorithmic age, Chinese "She Variety" has become a significant arena for the negotiation of gender relations. It plays an important role in feminist media communication, contributes to the reshaping of gender culture in the new media era, and offers a new perspective for understanding the transformation of gender dynamics in contemporary China.
Educação permanente em saúde aliada à política nacional de humanização/SUS: Relato de experiência no contexto hospitalar
Authors: Anna Gabriella Rodrigues Sant' , Santos Ana Elisa Maia
Published: January 2025

O presente artigo tem como objetivo apresentar relato de experiência do Núcleo de Educação Permanente, direcionada a área de educação hospitalar. Esta é uma proposta em conjunto com a equipe multiprofissional, constituída pelas áreas de Apoiador Institucional e Setor de Psicologia, tendo como ação o desenvolvimento de atividades de formação fundamentadas pela Política Nacional de Humanização e articulada na Política Nacional de Educação Permanente em Saúde, reforçando a instituição como lócus de atividade educacional. O relato desta experiência retrata uma atividade desenvolvida no âmbito do Hospital Regional do Médio Paraíba Drª. Zilda Arns Neumann, localizado em Volta Redonda, no Estado do Rio de Janeiro, entre os meses de janeiro e outubro de 2022, com um universo de 142 (cento e quarenta e dois) profissionais que participaram dos 10 (dez) encontros da atividade educacional, os quais compuseram a temática de discussão da empatia. Destaca-se, ainda, que as ações educacionais nas Unidades de Saúde se tornam um importante instrumento no cotidiano do trabalho, ao reforçá-lo com o lócus de formação, resultando melhoras na prestação do serviço com qualidade. Assim, reforçamos que as ações de educação permanente devem ocorrer continuamente nos serviços de saúde, baseadas nos princípios do SUS.
Perfil epidemiológico da COVID-19 no Estado do Rio de Janeiro: um panorama 2020-2022
Authors: Velasque Luciane , Nascimento Helena Silva do , Rocha Maíra Mendonça da , Nazário Gabriella da Cunha , Mesquita Peixoto Eduardo Mesquita , Menezes da Silva Marianna Menezes , Silva Cristina Freire da , De Carvalho Silvia Cristina , Bedin Shenon Bia , Carvalho Paula Rita Dias de Brito de , Almeida Paula Maria Pereira de , Almeida Aline Maria
Published: January 2025

Durante o período de 2020 a 2022, o Brasil passou por diversos picos de transmissão de Covid-19. O presente estudo objetivou descrever o comportamento das curvas de casos, internações e óbitos por Covid-19 do estado do Rio de Janeiro, entre março de 2020 a janeiro de 2023 Trata-se de um estudo transversal, descritivo, de abordagem quantitativa, utilizando dados secundários dos sistemas de informações nacionais e-SUS Notifica, SIVEP-Gripe e da base de dados das variantes circulantes. Durante o período do estudo foram confirmados 2.702.176 casos, 202.408 internações e 76.513 óbitos por Covid-19. O estado apresentou a maior mortalidade do país, correspondendo a 443,14 óbitos por 100 mil habitantes e uma letalidade de 2,83% do total de casos. As mulheres foram as mais diagnosticadas com Covid-19 (57,9%), entretanto, entre os óbitos, os homens foram os mais acometidos (53,2%). Pessoas acima de 70 anos (50,4%) e com comorbidades (66,8%) representaram maioria dos óbitos. No panorama apresentado é possível observar que enquanto a vacinação não estava disponível ocorreram importantes picos de gravidade da doença. Contudo, após ampliação da vacinação no estado, notou-se redução no registro de casos graves, havendo queda nas internações e óbitos pela Covid-19 no Estado do Rio de Janeiro.
acesso e acolhimento da população LGBTQIA+ na Atenção Primária à Saúde:
Authors: Santos Junior Gabriel Duarte dos , Oliveira Jaina Larissa Bastos Costa de
Published: January 2025

A população LGBTQIA+ vivencia situações que a coloca em contexto de vulnerabilidade social, como preconceito e LGBTfobia, que muitas vezes são reproduzidas no cenário da saúde, podendo gerar uma atitude de afastamento pelos usuários. A Atenção Primária à Saúde (APS) pode colaborar na aproximação com usuários da população e contribuir com a inclusão, acesso e cuidado. Logo, o objetivo deste escrito consistiu em analisar fragilidades e potencialidades apresentadas pelos profissionais da APS no acolhimento de usuários da população LGBTQIA+. O método consistiu em uma revisão integrativa. O levantamento de dados se deu em pesquisas nas bases de dados LILACS, BVS e SciELO, com os descritores: “Acolhimento”, “Pessoas LGBT” ou “Pessoas LGBTQIA+”, e “Atenção Primária à Saúde” ou “Atenção Básica”. Na análise, foram identificadas dificuldades quanto aos acolhimentos, como a reprodução de discursos preconceituosos e estigmatizantes pelos profissionais, assim como uma fragilidade no princípio da integralidade, visto que diversas ações e atendimentos tiveram ênfase limitada às infecções sexualmente transmissíveis. A realização de acolhimentos não qualificados pode prejudicar o acesso desses usuários. Aponta-se a necessidade de fomentar processos de formação profissional sensíveis às temáticas de saúde da população LGBTQIA+, para corroborar na capacitação profissional com uma visão ampliada de saúde.
Challenges of Sustainable Haor Management in Bangladesh: A Study on Hakaluki Haor
Authors: Ghosh Dipto , Hamid Dr. Md. Abdul
Published: January 2025

The objectives of the study were (i) to sketch the current haor management practices in Bangladesh; (ii) to identify the challenges of sustainable management of haor resources; and (iii) to explore the scope of such management which can be helpful in achieving SDGs in Bangladesh. The study was qualitative primary data focused. Based on judgement 10 KII were selected. They are related to haor management, local government, media, and research. Based on the KII opinion and secondary data, an open-ended questionnaire was developed. Then 20 stakeholders were selected for an in-depth interview. Respondents were fishermen, farmers, local community members, traders, government officials and NGO representatives. A focus group discussion has also been conducted to understand the overall management scenario of Hakaluki haor area. Collected data have been analyzed for thematic contents and compared between KII and FGD by using triangulation in terms of data reliability. Water contamination of the studied area impacts plant and animal life in recent years. Lessening of natural resources causing harm of haor biodiversity. Increasing number of pollutants, unplanned expansion of agricultural activities, overfishing, use of insecticides and pesticides are damaging the wetland ecology. The degradation of marsh wetlands also impacts on livestock feed availability. Other issues are encroachment of upstream dams, undue influence of regional groups, drying up water sources, filling out wetland areas, uncontrolled hunting, unplanned constructions, reluctance of the concerned authorities, multifaceted corruption, and lack of awareness among the active stakeholders. To improve the current scenario and using haor as a tool of achieving SDGs, some policy suggestions have been given. Findings of this study can be used in further policy formulation. To minimize the challenges community empowerment and proper collaboration can be applied. Evidence-based decision making, and adaptive management approaches can be helpful in our overall sustainable development. This study has been conducted based on qualitative data of a limited number of respondents. Incorporating a large number of respondents and quantitative data could present a wider scenario. Moreover, comparing the realities of other hoar areas could explore different dimensions of sustainable haor management.
Accounting Information System as a Means of Enhancing Financial Management in Educational Institutions: A Study on Sylhet Metropolitan City
Authors: Md. Nasir Uddin
Published: January 2025

The objective of this study is to evaluate how Accounting and Information Systems (AIS) enhance financial management practices in educational institutions. This project explores the role of AIS in enhancing the financial management practices of educational institutions. The study is descriptive in nature and employs a quantitative approach. Data were collected and analyzed to explore various factors associated with the performance of the accounting information system in these institutions. To this end, both primary and secondary data were utilized. This study is based on a sample of 60 employees working in different educational institutions within Sylhet Metropolitan City. Convenience sampling, a non-probability sampling method, was used to select the sample size. Collected data were reviewed and analyzed using SPSS 22. A semi-structured questionnaire with 11 variables was administered to collect data from respondents. Responses were measured on a 5 point Likert scale ranging from "strongly disagree" to "strongly agree." The study demonstrates the effectiveness of AIS implementation in optimizing financial processes within the institution. It also identifies integration opportunities within financial management to assess areas for improvement, evaluates challenges in the implementation and utilization of AIS, and reveals positive feedback from respondents. This study contributes to the existing body of knowledge by offering insights and recommendations that can inform future AIS implementation strategies in educational institutions. The ultimate aim of this paper is to improve financial decision-making processes and optimize resource allocation in educational institutions through the effective utilization of AIS.
Russian language in the educational environment of the Republic of Tajikistan
Authors: Khalimzoda Ziyovidin Amirkhudzha
Published: January 2025

This article is devoted to the issue of studying the Russian language in the field of education of the Republic of Tajikistan, as well as in secondary schools, where education is conducted entirely in the Tajik language, taking into account the increased efficiency of mastering the Russian language. The question is raised about the need to take into account the native language of students when teaching Russian to Tajik schoolchildren. The grammatical categories of number, gender and case of the noun in the analyzed languages are analyzed, and the similarities and differences of the concepts under consideration are determined. Particular attention is paid to the issues of teaching the Russian language due to the fact that in the linguistic conditions of Tajikistan, in the absence of a natural Russian-speaking environment, the education system bears the main burden in learning and preserving the language. Today, among the various directions of socio-economic development of Tajikistan, special attention is paid to the issue of learning languages, especially Russian. Indeed, every year in our country the number of people interested in learning Russian and other languages of the East and West is increasing, and the number of young people interested in learning several languages is increasing every year. In the Republic of Tajikistan (RT), the educational process in the Russian language in secondary schools is built on a new program.Today, among the various directions of socio-economic development of Tajikistan, special attention is paid to the issue of learning languages, especially Russian. Indeed, every year in our country the number of people interested in learning Russian and other languages of the East and West is increasing, and the number of young people interested in learning several languages is increasing every year.
The means of verbalizing will expression in a literary text as the dominants of the author’s idiostyle (exemplified by I. Bachmann’s novel "Malina")
Authors: Tolparova Dzerassa Valerievna
Published: January 2025

The imperative mood expresses the will of the communicative act’s producer and requires a verbal or non-verbal reaction from the recipient. This article is devoted to the study of ways to implement voluntariness in the language of a literary work. The material for this work is the novel "Malina" by the Austrian writer Ingeborg Bachmann. The object of the study is the category of motivation as a way of expressing the will of the producer. The article examines the grammatical and lexical means of verbalizing will that are presented in the analyzed novel by a wide range of forms of explicit and implicit expression of motivation. Special attention is paid to the verb form of the 2nd person singular which forms the core of the imperative mood category and takes priority by the highest frequency of use in I. Bachman's idiolect. The following methods were used in the course of the study: descriptive method, structural method, component analysis method, logical comparison method, statistical analysis method. The scientific novelty of the study lies in the fact that for the first time an attempt was made to establish a correlation between the degree of use frequency of will manifesting means of the writer, characterized by the desire to change the surrounding reality. The analysis of empirical material revealed the tendency for Ingeborg Bachmann to use most of the methods of verbalizing the imperative mood available in the German language. The main conclusion of the study is that indirect ways of expressing will (as well as direct ones) can be represented in artistic discourse by both grammatical and lexical means which are part of imperative structures with modal verbs, as well as elliptical constructions and can be narrative or interrogative sentences from the standpoint of communicative purpose.
The pragmatic function of neologisms in the modern Russian media discourse
Authors: Yaremchuk Aleksandr Vladimirovich
Published: January 2025

The subject of this article is the pragmatic function of neologisms in the modern Russian media discourse. The work is devoted to the study of the mechanisms of integration of both intra-linguistic and foreign-language neologisms into the media space of Russia, their role in creating expressiveness and effectiveness of communication. Special attention is paid to the analysis of lexical units capable of adapting to changing social and cultural conditions. Their influence on the formation of public perception, the implementation of various functions in media texts and their connection with current events are investigated. Examples include neologisms such as "anti-masochist", "remote", "storytelling" and "coworking". The analysis demonstrates how these elements contribute to the modernization of the language, its enrichment and reflection of current realities. The work focuses on the importance of media discourse as a tool for spreading and consolidating linguistic innovations.  The work uses methods of contextual analysis, lexico-semantic classification and interpretation of linguistic units, which allows to systematize and classify neologisms according to their functions in the media discourse. The scientific novelty of the study lies in the identification of the pragmatic function of neologisms in media discourse, demonstrating their key role in the formation of modern media texts. The author reveals that intra-linguistic neologisms contribute to the preservation of cultural identity by creating emotional expressiveness of texts, while foreign-language borrowings emphasize the international character of events and the modernization of language. The work reveals that the integration of neologisms allows the media discourse to remain relevant, modernized and communicatively effective. It is concluded that the use of neologisms in the media enriches the Russian language, contributes to the development of the cultural context and forms new ways of perceiving information. This research can become the basis for creating lexicographic and translation solutions, as well as for optimizing media and advertising communication strategies.
Benchmarking and Optimization of Methods for the Detection of Identity-By-Descent in High-Recombining Plasmodium falciparum Genomes
Authors: Guo Bing , Takala-Harrison Shannon , O’Connor Timothy D
Published: January 2025

Genomic surveillance is crucial for identifying at-risk populations for targeted malaria control and elimination. Identity-by-descent (IBD) is increasingly being used in
Plasmodium
population genomics to estimate genetic relatedness, effective population size (

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), population structure, and signals of positive selection. Despite its potential, a thorough evaluation of IBD segment detection tools for species with high recombination rates, such as
P. falciparum
, remains absent. Here, we perform comprehensive benchmarking of IBD callers – probabilistic (hmmIBD, isoRelate), identity-by-state-based (hap-IBD, phased IBD) and others (Refined IBD) – using population genetic simulations tailored for high recombination, and IBD quality metrics at both the IBD segment level and the IBD-based downstream inference level. Our results demonstrate that low marker density per genetic unit, related to high recombination relative to mutation, significantly compromises the accuracy of detected IBD segments. In genomes with high recombination rates resembling
P. falciparum
, most IBD callers exhibit high false negative rates for shorter IBD segments, which can be partially mitigated through optimization of IBD caller parameters, especially those related to marker density. Notably, IBD detected with optimized parameters allows for more accurate capture of selection signals and population structure; IBD-based

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inference is very sensitive to IBD detection errors, with IBD called from hmmIBD uniquely providing less biased estimates of

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in this context. Validation with empirical data from the MalariaGEN
Pf
7 database, representing different transmission settings, corroborates these findings. We conclude that context-specific evaluation and parameter optimization are essential for accurate IBD detection in high-recombining species and recommend hmmIBD for quality-sensitive analysis, such as estimation of

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in these species. Our optimization and high-level benchmarking methods not only improve IBD segment detection in high-recombining genomes but also enhance overall genomic analysis, paving the way for more accurate genomic surveillance and targeted intervention strategies for malaria.
Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation
Authors: Wang Yanbin , Wu Yuqi , Zhang Hong , Zhou Xiao , Song Anping , Qiu Hong , Yuan Xianglin , Xiong Hua , Zou Yanmei
Published: January 2025

Hepatocellular carcinoma (HCC) is a highly aggressive tumor characterized by significant heterogeneity and invasiveness, leading to a lack of precise individualized treatment strategies and poor patient outcomes. This necessitates the urgent development of accurate patient stratification methods and targeted therapies based on distinct tumor characteristics.By integrating gene expression data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Gene Expression Omnibus (GEO), we identified subtypes through a multi-omics consensus clustering approach amalgamated from 10 clustering techniques. Subsequently, we developed a prognostic model, employing machine learning algorithms, based on subtype classification features. Finally, by analyzing single cell sequencing data, we investigated the mechanisms driving prognostic variations among distinct subtypes.First, we developed a novel consensus clustering method that categorizes liver cancer patients into two subtypes, CS1 and CS2. Second, we constructed a prognostic prediction model, which demonstrated superior predictive accuracy compared to several models published in the past five years. Finally, we observed differences between CS1 and CS2 in various metabolic pathways, biological processes, and signaling pathways, such as fatty acid metabolism, hypoxia levels, and the PI3K-AKT signaling pathway.
Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology
Authors: Nemec Kelsey M , Uy Genevieve , Chaluvadi V Sai , Purnell Freddy S , Elfayoumi Bilal , O’Brien Carleigh A , Aisenberg William H , Lombroso Sonia I , Guo Xinfeng , Blank Niklas , Oon Chet Huan , Yaqoob Fazeela , Temsamrit Brian , Rawat Priyanka , Thaiss Christoph A , Wang Qingde , Bennett Mariko L , Bennett F Chris
Published: January 2025

Microglia, the brain’s resident macrophages, can be reconstituted by surrogate cells - a process termed “microglia replacement.” To expand the microglia replacement toolkit, we here introduce estrogen-regulated (ER) homeobox B8 (Hoxb8) conditionally immortalized macrophages, a cell model for generation of immune cells from murine bone marrow, as a versatile model for microglia replacement. We find that ER-Hoxb8 macrophages are highly comparable to primary bone marrow-derived (BMD) macrophages in vitro, and, when transplanted into a microglia-free brain, engraft the parenchyma and differentiate into microglia-like cells. Furthermore, ER-Hoxb8 progenitors are readily transducible by virus and easily stored as stable, genetically manipulated cell lines. As a demonstration of this system’s power for studying the effects of disease mutations on microglia in vivo, we created stable,
Adar1
-mutated ER-Hoxb8 lines using CRISPR-Cas9 to study the intrinsic contribution of macrophages to Aicardi-Goutières Syndrome (AGS), an inherited interferonopathy that primarily affects the brain and immune system. We find that
Adar1
knockout elicited interferon secretion and impaired macrophage production in vitro, while preventing brain macrophage engraftment in vivo - phenotypes that can be rescued with concurrent mutation of
Ifih1
(MDA5) in vitro, but not in vivo. Lastly, we extended these findings by generating ER-Hoxb8 progenitors from mice harboring a patient-specific
Adar1
mutation (D1113H). We demonstrated the ability of microglia-specific D1113H mutation to drive interferon production in vivo, suggesting microglia drive AGS neuropathology. In sum, we introduce the ER-Hoxb8 approach to model microglia replacement and use it to clarify macrophage contributions to AGS.
Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA
Authors: Casu Bastien , Sallmen Joseph W , Haas Peter E , Chandra Govind , Afanasyev Pavel , Xu Jingwei , Schlimpert Susan , Pilhofer Martin
Published: January 2025

Bacterial contractile injection systems (CIS) are phage tail-like macromolecular complexes that mediate cell-cell interactions by injecting effector proteins into target cells. CIS from
Streptomyces coelicolor
(CIS
Sc
) are localized in the cytoplasm. Under stress, they induce cell death and impact the bacteria’s life cycle. It remains unknown whether CIS
Sc
require accessory proteins to directly interact with the cytoplasmic membrane and function.Here, we characterize the putative membrane adaptor CisA, a conserved factor in
CIS
gene clusters across
Streptomyces
species. We show by cryo-electron tomography imaging and
in vivo
assays that CIS
Sc
contraction and function depend on CisA. Using single-particle cryo-electron microscopy, we provide an atomic model of the extended CIS
Sc
apparatus; however, CisA is not part of the complex. Instead, our findings show that CisA is a membrane protein with a cytoplasmic N-terminus predicted to interact with CIS
Sc
components, thereby providing a possible mechanism for mediating CIS
Sc
recruitment to the membrane and subsequent firing.Our work shows that CIS function in multicellular bacteria is distinct from Type 6 Secretion Systems and extracellular CIS, and possibly evolved due to the role CIS
Sc
play in regulated cell death.
Upstream open reading frames buffer translational variability during Drosophila evolution and development
Authors: Sun Yuanqiang , Duan Yuange , Gao Peixiang , Liu Chenlu , Jin Kaichun , Dou Shengqian , Tang Wenxiong , Zhang Hong , Lu Jian
Published: January 2025

Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread
cis
-regulatory elements in eukaryotic genomes that regulate translation, but it remains unclear whether and how uORFs contribute to stabilizing protein levels. In this study, we performed ribosome translation simulations on mRNA to quantitatively assess the extent to which uORF translation influences the translational variability of downstream coding sequences (CDS) across varying contexts. Our simulations revealed that uORF translation dampens CDS translational variability, with buffering capacity increasing in proportion to uORF efficiency, length, and number. We then compared the translatomes at different developmental stages of two
Drosophila
species, demonstrating that uORFs buffer mRNA translation fluctuations during both evolution and development. Experimentally, deleting a uORF in the
bcd
gene—a prominent example of translational buffering—resulted in extensive changes in gene expression and phenotypes in
Drosophila melanogaster
. Additionally, we observed uORF-mediated buffering between primates and within human populations. Together, our results reveal a novel regulatory mechanism by which uORFs stabilize gene translation during development and across evolutionary time.
Quantification of the effect of hemodynamic occlusion in two-photon imaging
Authors: Yogesh Baba , Heindorf Matthias , Jordan Rebecca , Keller Georg B
Published: January 2025

The last few years have seen an explosion in the number of tools available to measure neuronal activity using fluorescence imaging (Chen et al., 2013; Feng et al., 2019; Jing et al., 2019; Sun et al., 2018; Wan et al., 2021). When performed in vivo, these measurements are invariably contaminated by hemodynamic occlusion artifacts. In widefield calcium imaging, this problem is well recognized. For two-photon imaging, however, the effects of hemodynamic occlusion have only been sparsely characterized. Here we perform a quantification of hemodynamic occlusion effects using measurements of fluorescence changes observed with GFP expression using both widefield and two-photon imaging. We find that in many instances the magnitude of signal changes attributable to hemodynamic occlusion is comparable to that observed with activity sensors. Moreover, we find that hemodynamic occlusion effects were spatially heterogeneous, both over cortical regions and across cortical depth, and exhibited a complex relationship with behavior. Thus, hemodynamic occlusion is an important caveat to consider when analyzing and interpreting not just widefield but also two-photon imaging data.