bluuebunny/crossref_metadata_2025 huggingface dataset:
A Bacteriúria Assintomática na Saúde Pública
Authors: Moura Hesron , Castilho Kessy Mary Lima de
Published: August 2023

A bacteriúria assintomática é caracterizada pela presença significativa de uropatógenos em amostras de urina de pacientes sem sintoma urinário e só deve ser tratada em grupos de pacientes em que os estudos clínicos demonstraram benefício. Entre a população adulta em geral, as mulheres, independente da faixa etária, tem maior prevalência de bacteriúria assintomática, embora observa-se aumento das taxas do quadro infeccioso conforme aumento da idade entre ambos os sexos. A prevalência de bacteriúria assintomática pode variar de acordo com idade, sexo, atividade sexual e presença de anormalidades geniturinárias. Quando o tratamento da bacteriúria assintomática não é indicado, a terapia antimicrobiana não diminui a morbidade da infecção sendo ainda associada a uma maior frequência de resultados negativos incluindo o surgimento de organismos resistentes e efeitos adversos relacionados aos medicamentos. Diante do exposto, o objetivo da presente revisão bibliográfica é apresentar a importância da bacteriúria assintomática na saúde pública.
Assessment of the Initial Result of Screw Fixation for Proximal Crescentic Metatarsal Osteotomy with Distal Soft Tissue Reconstruction in Severe Hallux Valgus Treatment
Authors: Mao Haijiao , Wang Linger , Yao Liwei , Dong Wenwei
Published: August 2023

Introduction:

Proximal crescentic metatarsal osteotomy and distal soft tissue reconstruction have been introduced to correct severe HV. The intrinsically unstable proximal first crescentic osteotomy depends on enough force fixation for stability. It is necessary to judge the number of fixation screws for osteotomy.

Method:

Fifty-two feet of 50 adult patients with severe HV were included in this study. The treatment was proximal crescentic metatarsal osteotomy with a single screw and distal soft tissue reconstruction in Group 1 and the fixation with two screws with distal soft tissue reconstruction in Group 2. Clinical and radiological follow-ups were assessed after 4 and 12 months of operation. In Group 1, HVA decreased from 46.4 ±3.28 to 19.9 ±4.70 after 12 months of operation and from 45.1 ±3.45 to 19.1 ±4.70 in Group 2. Regarding the intermetatarsal angle (IMA) in Group 1, it was changed from 18.5 ±1.98 to 9.25 ±1.11 after 12 months of operation. For group 2, it decreased from 18.3 ±1.81 to 9.53 ±1.70. Meanwhile, the AOFAS score improved from 63.1 to 83.9 after 12 months of operation in Group 1 and improved from 64.3 to 82.8 in Group 2.

Results:

Furthermore, the VAS score reduced from 4.5±1.01 to 1.7± 0.43 in Group 1 and from 4.7±0.92 to 1.7±0.55 in Group 2 after 12 months of operation. There were no significant differences identified between Group 1 and Group 2 in terms of VAS and AOFAS scores and HVA and IMA measurements.

Conclusion:

There is less complication in two-screw fixation for crescentic osteotomy compared to a single-screw fixation.
Amphotericin-B-Induced Chronic Kidney Disease in a Post-COVID-19
Patient with Widespread Rhinocerebral Mucormycosis and Pneumonia:
A Case Report
Authors: Johri Nishant , Choudhary Ambika , Rawat Ujjawal , Vengat Maheshwari
Published: August 2023

Background:

The COVID-19 pandemic has posed a unique challenge to the medical
community due to potential co-infections with bacteria and fungi. We report a case of Rhino
cerebral mucormycosis infection in a 67-year-old patient after recovery from COVID-19.

Objective:

To report a case of Rhino cerebral mucormycosis in a 67-year-old patient with preexisting
health conditions after recovering from COVID-19 and to highlight the importance of early
detection and treatment of co-infections in patients with pre-existing health conditions.

Case Presentation:

The patient had pre-existing health conditions, including uncontrolled diabetes,
hypertension, and Chronic obstructive pulmonary disease (COPD), which made him more vulnerable
to complications after COVID-19. He was admitted to the hospital after experiencing a dark
discharge from his left eye, later confirmed to be due to mucormycosis. Histopathological examination
revealed invasive mucormycosis, highlighting the importance of early detection and treatment.
However, the patient experienced Acute kidney injury (AKI) after only 5 days of treatment
with conventional amphotericin B, underscoring the need for careful monitoring and adjustment of
treatment regimens.

Discussion:

The case underscores the need for early detection and treatment of co-infections in
vulnerable patients. The patient's pre-existing conditions and immunocompromised state made him
more susceptible to the infection. The case also highlights the importance of careful monitoring
and adjustment of treatment regimens to minimize the risk of adverse effects.

Conclusion:

While COVID-19 has presented challenges and uncertainties, it has also provided
valuable insights into the interactions between infectious agents and the human body. Continued
research and vigilance are necessary to mitigate the impact of co-infections and improve outcomes
for patients.
Effect of adding chemical, organic fertilizers and spraying seaweed extracts on the availability of NPK and organic material in calcareous soil
Authors: Rahman Saleh Auf Abdul , Rahem Bader Basem
Published: August 2023

A field experiment was carried out in the agricultural season 2021-2022 in one of the farming fields in the region of Muqdadiya, Al-Harouniya district, located 40 km northeast of Baquba district of Diyala governorate. (Soil Survey Staff, 2006). It is located at a longitude of 53° 34' N and latitude of 56° 04° 45° S. The experiment aimed to study the effect of adding chemical and organic fertilizers and spraying seaweed extracts on NPKS concentrations and cauliflower yield. The investigation included three factors; the first factor was the addition of organic fertilizer (buffalo waste) at three levels (0, 5 and 10%) of the terrace size, which M1, M2 and M3 respectively symbolize. It was added at a depth of 0-30 cm a month before planting the seedlings in the field. The second factor was the addition of NPK compound chemical fertilizer (20:20:20) at two levels (0 and the full fertilizer recommendation is 300 kg H-1 when planted as a feed) and symbolized by C1 and C2, respectively. The third factor is spraying seaweed extract with three levels (0, 2 and 4) ml L-1 represented by A1, A2 and A3. The experiment results showed that adding chemical fertilizer significantly affected the availability of organic material in the soil. The 2C treatment (and the full fertilizer recommendation of 300 kg H-1) outperformed and reached 2.96 gm kg-1; nitrogen availability in the soil amounted to 2.96 %. As well as the availability of phosphorous in the soil, which amounted to 76.28 mg P kg 1-soil, and potassium availability in the soil amounted to 76.28 %. The addition of buffalo manure to calcareous soils significantly affected the readiness of the organic material. Also, treatments M2 and M3 outperformed in soil with a value of 3.34 and 23. 4 g/kg-1, and nitrogen availability in soil amounted to 29.88 and 31.25 mg N kg-1-. The M3 treatment also excelled in the availability of phosphorous in soils, which amounted to 86.98 mg P kg-1-soil mg M kg-1-soil. The availability of potassium in the soil amounted to 361.33 %. The triple interaction between the studied factors significantly affected the availability of organic material in soils. The M2×C2×A3 treatment also excelled in recording the highest value, which was 3.85 gm kg-1, nitrogen availability in soil amounted to 37.75 %, phosphorous availability in soil amounted to 94.16 mg P kg-1 and potassium availability in soil amounted to 436.42 mg kg1-soil.

Keywords: chemical fertilization, organic fertilization, seaweed extracts.
Assessing the Response of the Global South to Russo-Ukrainian War: Case Study of India
Authors: Basundoro Alfin Febrian , Abrar Muhammad Irsyad , Trystanto Trystanto
Published: August 2023

The Russian invasion of Ukraine on February 24, 2022, resulted in a prolonged war between the two countries. It creates a worldwide geoeconomic impact, including stagflation due to the disruption of the supply chains, profoundly affecting the economies of Global South countries. Additionally, the aggression contradicts the principles of sovereignty, territorial integrity, and independence that the Global South countries hold dear (United Nations, 2015). Despite these, most Global South countries, including India, refused to condemn Russia for its actions, except for the UN General Assembly vote to condemn Russia on March 2. This situation begs the question: Why would not India, one of the significant Global South countries, blame Russia for its detrimental actions to the ideals of the Global South? We argue that when national interests and values come into conflict, Global South countries may prioritize their interest rather than uphold the values deeply held by the Global South—a vindication that Realpolitik still held preeminence within the foreign policymaking of the Global South countries, including India. This is evident in India's response to the Russian aggression, as India still maintains a strategic partnership with Russia even after Russia tramples the values of the Global South via its war in Ukraine. At the same time, India tries to avoid being engaged closely with Russia as India still needs the support of the United States to balance China's geopolitical moves, given India's territorial disputes with China.
Contested Access in the Failing Urban Culinary Tourism Planning: A Case of Bogor, Indonesia
Authors: Multi Purnomo Agustina
Published: August 2023

This study explores the role of urban tourism planning at the national and regional levels in developing Indonesia’s culinary tourism destinations. Culinary destination tourism planning in Indonesia is under‐researched. This study aims to fill the gaps. Using the spatial triad analysis, this study explores the interrelatedness between the conceived-perceived-lived government planning activities in shaping culinary tourism destinations. Bogor City case was chosen because it has a higher culinary growth rate than other nearby cities. Bogor City analyzed in regional and national context. Based on the observations and the document studies, including text, promotion, publication, and document analysis, the research found that government culinary tourism planning has failed to develop culinary tourist destinations and attractions. The problem lies in the inconsistency between equivalent policies and the discontinuity between policy and implementation. The research findings indicate the governments lack of understanding of the subject matter and planning mechanisms. The culinary tourism planning activities have also created a classical contest of capital power. This research finding suggests the need for a better understanding of culinary tourism attractions and destinations and better planning mechanisms.
Fruits and Vegetables Detection using YOLO Algorithm
Authors: Kanakaprabha S. , Gopal Dr. Gaddam Venu , Kaleeswaran D. , Hemamalini D. , Ganeshkumar Dr. G.
Published: August 2023

The robotic harvesting platform's fruit and vegetable detection system is crucial. Due to uneven environmental factors such branch and leaf shifting sunshine, fruit and vegetable clusters, shadow, and so on, the fruit recognition has become more difficult in nowadays. The current method in this work is used to detect different types of fruits and vegetables in different size and shape. This method makes the use of OpenCV, Dark Flow, a TensorFlow variant of the YOLO technique. To train the necessary of network, a range of fruits and vegetable pictures were input into the network. The photos were pre-processed using OpenCV to create manual bounding boxes around the fruits and vegetables before into the training. YOLO detection algorithm is used. In, this method more accurately and rapidly recognizes of an item in an image. After the network has been trained, the test input is sent into the bounding boxes surrounding the recognized fruits and vegetables will be displayed as a consequence.
Vṛddhi traces in Hindi denominal derivation
Authors: Ramsammy Michael
Published: August 2023

This paper considers vṛddhi as an inherited feature in Modern Standard Hindi. As a phenomenon, vṛddhi is most commonly discussed in reference to Old Indo‐Aryan (OIA), particularly with a focus on inflectional patterns in Sanskrit. However, the inherited pattern in New Indo‐Aryan (NIA) languages presents specific analytical challenges and its status as a morpho‐phonological feature in the present‐day languages is not straightforward to establish. In this paper, the focus is given to the operation of vṛddhi in denominal derivations in both OIA and present‐day Hindi. This leads to a discussion of the evolution of vowel systems in the history of Indo‐Aryan. Regarding the question of how synchronic vṛddhi‐alternations can be accounted for theoretically, I present two possibilities: (i) that vṛddhi constitutes a phonologically active process of vowel lowering/tensing in Hindi; and (ii), that vṛddhi is a suppletive phenomenon synchronically, and thus, not derived by phonological rule.
Classification & Detection of Melanoma Skin Cancer in Early Stages Using CNN
Authors: Awhad Rupali S. , Barode Dinesh M. , Kawathekar Seema S.
Published: August 2023

Abstract: Melanoma, sometimes referred to as skin cancer, is one of the most severe forms of skin disease. Applying UV radiation to the skin effects or modifies the melanocytes, leading to uncontrolled cell growth and skin burning or shading. Some skin conditions, however less frequent than others, are still harmful because, if untreated, they will probably worsen and spread. Early on, it might not get the proper care. A biopsy is the standard procedure for finding skin cancer and it entails scraping out the patient's skin lesion and sending it for laboratory testing. This strategy is uncomfortable, difficult, and tiresome. A dermatologist must put a lot of work into treating skin cancer from melanoma. In this study, a novel approach is used to detect skin cancer using machine learning. Dermoscopy images of melanoma cancer make it easier and less tedious to detect skin cancer.
The Effect Of Fiscal Decentralization On The Open Unemployment Rate In The Province Of DIY
Authors: Iqbal
Published: August 2023

This study aims to find empirical evidence on the effect of general allocation funds, special allocation funds, production sharing funds, and spending on goods and services on the open unemployment rate. The data used in this study is panel data, a combination of time series data (2012-2020), and cross-sectional data (5 regencies/cities in the Special Province of Yogyakarta). The results show that the Special Allocation Fund and Revenue Sharing Fund significantly positively affected the Open Unemployment Rate in the Special Region of Yogyakarta Province from 2012-2020.
Analysis of Government Expenditure Response, Foreign Direct Investment, Human Development Index and Inclusive Economic Growth in Indonesia
Authors: Ilmi Marina  , Satrianto Alpon
Published: August 2023

This study aims to analyze the response to shocks that occur between the variables Government Expenditure, Foreign Investment, Human Development Index, and Inclusive Economic Growth. This type of research is descriptive and inductive. The data used are panel data for 34 provinces in Indonesia from 2012-2020, data obtained from related agencies. The analysis method used is the Panel Vector Error Correction Model (PVECM). The results of this study show that: (1) The response to government expenditure in the education function due to the shock of inclusive economic growth is positive, (2) The response to government expenditure in the health function due to the shock of inclusive economic growth is positive (3) The response to government expenditure in the economic function due to the shock of inclusive economic growth is negative (4) The response of foreign investment due to the shock of inclusive economic growth is negative (5) The response of the human development index due to the presence of  Shock of Inclusive Economic Growth Is Positive.
Corazón que ríe, corazón que llora, de Maryse Condé: una lectura desde la literatura poscolonial, el feminismo y el psicoanálisis
Authors: Blanco-Ramos Roberto Antonio
Published: August 2023

Se analiza la obra Corazón que ríe, corazón que llora. Cuentos verdaderos de mi infancia, de la escritora guadalupana Maryse Condé mediante tres vertientes teóricas y metodológicas que responden a una lógica deconstructiva. Se refiere a la literatura poscolonial, el psicoanálisis y el feminismo afrodescendiente. El examen realizado permite establecer determinaciones significativas sobre la construcción histórica literaria de la narrativa poética de la autora y la representación del legado de la colonialidad del poder en términos de raza, saberes de poder, resistencia y género. Metodológicamente, desde las teorías y perspectivas poscoloniales se analiza discursivamente la obra. Se concluye que el texto de la autora ayuda a comprender la configuración  de procesos de resignificación fundamentada por medio de un compromiso sociopolítico y en la identificación de una feminidad negra resignificada.
Sistema de numeración para ejemplares bovinos con la finalidad de mostrar la edad y el sexo
Authors: Bareño Gómez Yeni Nini , Gómez García Farín Samir , Torres Diana Milena
Published: August 2023

Contextualización: La nomenclatura de numeración para ejemplares bovinos esta desarrollado bajo el uso de conceptos de informática, para la adaptación de las tecnologías de la información y comunicación (TIC) en la zootecnia dentro de la ganadería de precisión. Vacío de conocimiento: Esta metodología proporcionará un manejo sostenible, ayudando al productor a reducir costos de inversión en tecnología, contribuyendo a la implementación de producciones pecuarias y al bienestar de los animales, estableciendo que la tecnología ayuda a simplificar los manejos tradicionales. Propósito: Desarrollar una nomenclatura de numeración que se pueda integrar a la ganadería de precisión teniendo en cuenta el auge de la era digital, con el fin de conocer la edad y el sexo de cada ejemplar de forma individual, dando una herramienta tecnológica al zootecnista actual. Metodología: Se aplico la metodología nomenclatura de numeración de nuevos nacimientos ejemplares bovinos, para mostrar la edad y el sexo, este sistema de numeración se llevó a cabo mediante la utilización de tatuaje y hierro candente, lo diferente es la nomenclatura del número a utilizar, ya que fue desarrollado por un algoritmo de 4 dígitos donde cada parte de ellos corresponde a una secuencia lógica no computacional cualitativa, llevado a establecer un número como identificación de un ejemplar acorde a la fecha de nacimiento y su sexo. Esto se llevó a cabo en el departamento del Vichada que está en aislamiento tecnológico; es un departamento que tiene extensas llanuras posee suelos aptos para la agricultura y para la ganadería que son promisorios para todo tipo de manejo agropecuario de precisión. Resultados y conclusiones: Con esta investigación se incursionará en el manejo de las TIC obteniendo información pormenorizada de los ejemplares bovinos que ayudará a la toma de decisiones en los diferentes sistemas de ganadería tradicional y de precisión, además se sistematizará la información adquirida de forma digital para un uso adecuado y un mejor control
Early moderate catch-up growth after birth helps IUGR rats achieve good pulmonary vascular and cognitive function in adulthood
Authors: Zhong Du Li , Ye Lixia , Huang Yajie , Chen Kewei , Hang Chengcheng , ying Yuhan , Zu Lu , Luo Xiaofei
Published: August 2023

Background and aims: Intrauterine growth restriction (IUGR) with
postnatal catch-up growth is strongly associated with pulmonary vascular
dysfunction in adulthood, and postnatal nutrient restriction leads to
long-term brain deficits. In this study, we hypothesize that early
moderate catch-up growth can alleviate pulmonary vascular remodeling
without affecting their memory function. Additionally, we investigated
whether pulmonary artery smooth muscle cells (PASMCs) and pulmonary
vascular endothelial cells (PVECs) were involved in pulmonary
hypertension caused by rapid catch-up growth. Methods and
results: We established an IUGR model by limiting maternal nutrition
during pregnancy, and created different growth patterns by adjusting the
number of offspring in each group during lactation. Three different time
points from infancy to adulthood (3w, 9w, and 13w) were chosen for
subsequent studies. The Y-maze was used to evaluate the rats’ cognitive
function. The results showed that deficits in memory function due to
delayed growth were associated with reduced proliferation of neural stem
cells in the subgranular zone (SGZ) of the hippocampus. Furthermore,
moderate catch-up growth improved memory function without affecting
mPAP, while rapid catch-up growth increased susceptibility to
cardiovascular diseases in adulthood. Higher mPAP, thickened pulmonary
artery media, narrowed vessel lumen, and increased pulmonary small
vessel muscularization confirmed this. PASMCs in the adult rats that
underwent rapid catch-up growth exhibited excessive proliferation,
migration, and anti-apoptotic activity, while PVECs also exhibited
excessive proliferation. Conclusion: The results suggest that
moderate catch-up growth after IUGR is better for optimal cognition and
cardiovascular health in adulthood than rapid catch-up growth or delayed
growth.
Pharmacological inhibition of STING reduces neuroinflammation-mediated damage post-traumatic brain injury
Authors: Fryer Amelia , Abdullah Amar , Mobilio Frank , Moore Zachery , Zheng Gang , Veer Michael de , Wong Bruce , Taylor Juliet , Crack Peter
Published: August 2023

Background and Purpose: Traumatic brain injury (TBI) remains a major
public health concern worldwide with unmet effective treatment.
Stimulator of Interferon Genes (STING) protein and its downstream type-I
Interferon (IFN) signaling are now appreciated to be involved in TBI
pathogenesis. Compelling evidence have shown that STING and type-I IFNs
are key in mediating detrimental neuroinflammatory response after TBI,
exacerbating outcome. Therefore, pharmacological inhibition of STING
presents a viable therapeutic opportunity in combating the detrimental
neuroinflammatory response after TBI. Experimental Approach: This study
investigated the neuroprotective effects of the small-molecule STING
inhibitor C-176 in the controlled-cortical impact (CCI) mouse model of
TBI in 10–12-week-old male mice. 30-minutes post-CCI surgery, a single
750nmol dose of C-176 or saline (vehicle) was administered
intravenously. Analysis was conducted 2h- and 24h-post TBI. Key Results:
Mice administered C-176 had significantly smaller cortical lesion area
when compared to vehicle-treated mice 24h post-TBI. Quantitative
temporal gait analysis conducted using DigiGait™ showed C-176
administration attenuated TBI-induced impairments in gait symmetry,
stride frequency and forelimb stance width. C-176-treated mice displayed
a significant reduction in striatal gene expression of pro-inflammatory
cytokines TNF-α, IL-1β and CXCL10 compared to their vehicle-treated
counterparts 2h post-TBI. Conclusion and Implications: This study
demonstrates the neuroprotective activity of C-176 in ameliorating acute
neuroinflammation and preventing white matter neurodegeneration
post-TBI. This study highlights the therapeutic potential of
small-molecule inhibitors targeting STING for the treatment of trauma
induced inflammation and neuroprotective potential.
Retracing the center of origin and evolutionary history of nutmeg Myristica fragrans, an emblematic spice tree species
Authors: Kusuma Jakty , Scarcelli Nora , Navascués Miguel , Couderc M. , Gerard Pierre , Duminil Jérôme
Published: August 2023

The identification of cultivated plant centers of origin is of growing
interest since the pioneering work of Nikolaï Vavilov. Cultivated
species generally show a high level of genetic diversity in their center
of origin, thus identifying these areas would have important
implications for the conservation and sustainable management of their
genetic resources. We aim to identify the center of origin and to infer
recent evolutionary history of one of the most emblematic spice tree
species ¬¬– nutmeg (Myristica fragrans; Myristicaceae). The species is
thought to originate from the Banda islands (Southern Moluccas
archipelago, Indonesia), but this has never been confirmed. We
characterized the genetic diversity of this species across the Moluccas
archipelago using recently developed nuclear microsatellites markers and
whole plastid genome sequences. We found two main intra-specific genetic
clusters: one in South Moluccas (Banda and Ambon islands) and another in
North Moluccas (Ternate, Tidore and Bacan islands). The latter cluster
showed higher genetic diversity than the South Moluccas cluster. We then
inferred the demographic history of nutmeg and evaluated different
evolutionary scenarios using Approximate Bayesian Computation (ABC)
analyses. Populations from South Moluccas show patterns of a recent
bottleneck, whereas North Molucca populations did not. Moreover, South
Moluccas populations are inferred as ancestral, with subsequent
population migration to the North Moluccas during the late Pleistocene
to early Holocene period. These results have strong implications for
conservation strategies of nutmeg.
Patterns of aeroallergen sensitisation at a tertiary paediatric hospital in Sydney, Australia.
Authors: Swamy Shruti , Dai Danyi , Campbell Dianne , Katelaris Connie
Published: August 2023

Objective: To examine patterns of aeroallergen sensitisation in
atopic children and adolescents from a tertiary paediatric hospital in
Sydney, NSW. Method: Retrospective cross-sectional study of
atopic children who underwent aeroallergen skin testing (SPT) at a
tertiary children’s hospital (May 2013-Dec 2014). Participants were
eligible where all the following aeroallergens were tested including;
Rye, Bahia, Bermuda, English plantain, house dust mite (D.pteronyssinus
and D.farinae), cat, dog and Alternaria and they had a positive SPT to
at least one allergen (≥3mm). Results: 517 participants were
included, with a median age of 9.2 years (IQR 6.3-11.4). The most common
sensitisation was HDM (90%), with Rye grass (45%) being the most
common grass pollen. 93% of participants were polysensitised
(>1 allergen), with number of aeroallergen sensitisations
increasing with age (Pr>ChiSq <0.0001). Preschool
children were predominantly sensitised to HDM, with lower rates of grass
sensitisation, compared with the teenage group who had similar rate of
HDM sensitisation, but higher rates of grass sensitisation. Based on
history of atopic dermatitis, asthma, allergic rhinitis, the largest
proportion of Alternaria sensitisation was observed in participants with
atopic dermatitis, and the largest proportion of pollen sensitisation in
participants with allergic rhinitis. Conclusion: In this
cohort, sensitisation with HDM and grass pollen was the most common;
most participants were polysensitized, which increased with age. Overall
these patterns were similar to those described in paediatric populations
globally, particularly in temperate regions.
Paraneoplatic pruritus in a 7-year-old Slovak warmblood with malignant round cell tumour.
Authors: Rovňanová Natália , Kostolániová Veronika , Lešková Katarína , Hurta-Csizmár Sandra , Žert Zdeněk
Published: August 2023

A seven year old Slovak warmblood gelding, used as a police horse,
initially presented to the refferal clinic when it was five years old,
with an itching keloid on the distal limb, requiring surgical removal.
After surgical removal of the keloid and successful closure of the skin,
it was necessary to maintain bandaging the healed wound to prevent self
mutilation as the healed surgical site remained pruritic post
operatively. After two years, the horse presented to the clinic again
with pruritic and alopetic regions of the head, neck, limbs and base of
the tail. Attempts to find the cause of dermal iritation included
dermatological, parazitological, microbiological and ultrasonographic
examination. Treatment with corticosteroids, antiparasitics and
antibiotics were not succesfull. Further investigation due to the
horse’s worsening general status led to the finding of marked pleural
effusion. Cytology of the pleural fluid confirmed there was, as
suspected, neoplastic changes in the thoracic cavity. Furthermore there
were gross pathological changes of the lymphatic tissue of the cranial
mediastinum, surroundings of the aorta in the thoracic cavity and lymph
nodes of the abdominal cavity. Histolology of the lymphatic nodes found
poorly differentiated round cell tumours. Histopathological findings
confirmed there was a very aggressive form of lymphoma. The pruritus,
generalised moth-eaten alopecia and self-mutilation were the first
symptoms of the terminal disease in this case.
Why is there an Error Negativity on correct trials? A reappraisal
Authors: Ramdani Céline , hasbroucq thierry , Vidal Franck
Published: August 2023

In healthy subjects, the Error Negativity (Ne) was initially reported on
errors and on partial errors,only. Later on, application of the
Laplacian transformation to EEG data unmasked a Ne-like wave (Nc) that
shares a main generator with the Ne, suggesting that the Nc is just a
small Ne. However, the reason why a small Ne would persist on correct
responses remains unclear. Now, sometimes, subthreshold EMG activations
in the muscles corresponding to correct responses (not strong enough to
reach the response threshold) can precede full-blown correct responses.
These “partially correct” activities seem to correspond to (force)
execution errors, as they evoke a sizeable Ne. Within the frames of the
Reward Value and Prediction Model or of the Predicted Response-Outcome
model we propose that the action monitoring system evokes a Ne/Nc on
correct responses because, even when a correct choice has been made, the
accuracy of response (force) execution cannot be fully predicted. If
this interpretation is correct, it can be assumed that, once these
execution errors have been corrected, the correctness of the
(full-blown) correcting response is highly predictable. Consequently,
they should evoke a smaller Nc/Ne than “pure” correct responses. We
show, that for the response thresholds set in the present experiment,
the correcting response of the trials containing a partially correct
activation evoke no identifiable Nc at all. Therefore it seems that
there usually is an error negativity on correct trials because the
correctness of response (force) execution cannot be fully predicted.
A Generic Pump-free Organ-on-a-Chip Platform for Assessment of Drug Bioavailability
Authors: Guo Yaqiong , Xie Yingying , Qin Jianhua
Published: August 2023

Organ-on-a-chip technology has shown great potential in disease modeling
and drug evaluation. However, traditional organ-on-a-chip devices are
mostly pump-dependent with low throughput, which makes it difficult to
leverage their advantages. In this study, we have developed a generic,
pump-free organ-on-a-chip platform consisting of a 32-unit chip and an
adjustable rocker, facilitating high-throughput dynamic cell culture
with straightforward operation. By utilizing the rocker to induce
periodic fluid forces, we can achieve fluidic conditions similar to
those obtained with traditional pump-based systems. Through constructing
a gut-on-a-chip model, we observed remarkable enhancements in the
expression of barrier-associated proteins and the spatial distribution
of differentiated intestinal cells compared to static culture.
Furthermore, RNA sequencing analysis unveiled enriched pathways
associated with cell proliferation, lipid transport and drug metabolism,
indicating the ability of the platform to mimic critical physiological
processes. Additionally, we tested seven drugs which represent a range
of high, medium, and low in vivo permeability using this model and found
a strong correlation between their Papp values and human Fa, indicating
reliable and predictive simulation outcomes for drug absorption. Our
findings highlight the potential of this pump-free organ-on-a-chip
platform as a valuable tool for advancing drug development and enabling
personalized medicine.
3D inversion scheme for high-resolution analysis of continental scale Magnetotelluric data
Authors: Singh Arun , Dehiya Rahul
Published: August 2023

This study introduces a novel method for performing 3D inversion of
magnetotelluric (MT) data. The proposed method, referred to as the
radiation boundary scheme, employs a two-step simulation strategy for
the computation of both forward and adjoint responses. One of the key
advantages of the scheme is its ability to handle arbitrarily shaped
inversion domains, thereby optimizing the number of unknown model
parameters by discarding model parameters that are not constrained by
the data. Consequently, it significantly improves accuracy and
computational speed as compared to traditional inversion algorithms. The
effectiveness of the developed algorithm is demonstrated through a
comprehensive analysis of 3D inversion using synthetic and two
continental-scale (SAMTEX and USArray) MT data. The method’s efficiency
facilitates a detailed analysis of large-scale MT data inversion.
Through numerical experiments, it is observed that using a coarse mesh
for inversion, the resolution is compromised in the shallower part,
resulting in inferior imaging and, consequently, affecting the
estimation of resistivity value in the deeper subsurface. The detailed
numerical experiments indicate that performing a high-resolution
inversion on a small portion of the survey data utilizing a coarsely
inverted model may run into a local minimum. Hence, caution should be
exercised in employing such an approach. Instead, the investigations
suggest simultaneously executing a high-resolution inversion on the
entire data set. The forward/adjoint problem can be solved with a
two-order higher tolerance as compared to the conventional
finite-difference-based inversion algorithm. Therefore, the proposed
algorithm holds significant value for the MT inversion of large data
sets.
Anholonomic surfaces via directional motion of curves
Authors: Korpinar Talat , Demirkol Rıdvan , Korpinar Zeliha
Published: August 2023

While there are many scientific manuscripts devoted to various details of the
evolution of curves and their models, there are still many perspectives of
the research subject that required comprehensive investigation. In
particular, this manuscript is devoted to the search of a new class of time
evolution equations of space curves written in the anholonomic coordinates.
In this way, we have direct observation and access to form a new class of
anholonomic surfaces induced by the given evolution systems. Thus, the
proper representation of the evolution equations allows us to obtain useful
characteristics of the corresponding evolution dynamics.
Study on kinetic parameters of pebble bed reactor with TRISO duplex fuel
Authors: Zuhair Z , Luthfi Wahid , Dwijayanto Andika , Rohanda Anis , Suwoto S
Published: August 2023

Thorium, in this case, 232Th has a higher thermal neutron capture
cross-section than 238U, which means that more fertile isotopes can be
transmuted and could lead to higher fissile isotope 233U. In addition,
233U has a good performance in the thermal spectrum. Theoretically, a
nuclear reactor using thorium fuel can also last longer than one using
uranium fuel. The use of TRISO duplex fuel is predicted to produce better
neutronic behavior in a pebble bed reactor. This work aims to study the
kinetic parameters of a pebble bed reactor with TRISO duplex fuel. The
configuration of the TRISO duplex fuel pebble consists of an inner region
filled with UO2 TRISO particles and an outer region filled with
ThO2 TRISO particles surrounded by a graphite matrix of fuel pebble.
Three configurations with volume fraction of UO2-ThO2 were considered in
this study: 80-20 %, 75-25 %, and 70-30 %. The HTR-10 reactor was chosen
as a reactor model because its geometry and material
specifications are known. A series of calculations were conducted
using the Monte Carlo transport code MCNP6 and ENDF/B-VII.1 nuclear
data library. The calculation results were then analyzed to investigate the
effect of UO2 and ThO2 compositions in TRISO duplex fuel on the kinetic
parameters of the pebble bed reactor with various TRISO packing fractions of
1-50 %. It can be concluded that the utilization of TRISO duplex fuel in a
pebble bed reactor could significantly affect the core multiplication
factor and kinetic parameters caused by an increase in Th content. On the
other hand, the TRISO packing fraction is taking part in neutron moderation since a lower packing fraction means higher moderation for fueled
pebble.
Influence of gaseous laser in continuous-wave and pulse regimes on biomaterial characteristics
Authors: Jevtic Sanja , Sreckovic Milesa , Mitrovic Nebojsa , Zarubica Katarina , Zarubica Veljko , Janicijevic Aco , Stevic Zoran
Published: August 2023

Aromatic plants and laser beam wavelength in the red range of visible spectra
(623.8 nm), most commonly used for treating plant species, were selected. As
there is not much information in the references, it is necessary to set a
scale with qualitative and partially quantitative evaluations of the results.
Specimens of thyme seed (Thymus vulgaris) were selected as aromatic plants
for studying the effect of low-power lasers on plant development, and
continuous He-Ne laser, with irradiation times in the range of minutes.
Indoor radon monitoring in various ventilation degree in some schools of Duhok City, Iraq
Authors: Alhamdi Walat
Published: August 2023

Radon is a radioactive noble gas, recognized as a carcinogenic agent, being
affected by degree of ventilation. The aim of this preliminary study was to
determine the concentration of indoor radon gas in schools, to estimate the
main factors affecting their radon concentration levels and to analyze the
effective dose received by students in Duhok schools. Therefore, the
concentrations of radon were measured in 28 classrooms, from 13 schools
located in Duhok city, using both RAD7 and Corentium monitor, from January
15-30, 2021. In all schools indoor radon was measured in four different
scenarios of closed, natural and mechanical ventilation then, radon reduction
rate between each case was calculated. In addition to that, exposure to
annual effective dose of radon, for each different degree of ventilation, was
evaluated. Furthermore, effects of building floors were studied. Results
showed that maximum radon concentration, 121 Bqm-3, was recorded in closed
ventilation, while minimum, 15 Bqm-3, was recorded in mechanical ventilation.
Radon reduction rate in a mechanical ventilation is relatively large 81%.
Also, results demonstrate that indoor radon levels at first floor, in all
schools under study, were considerably greater than those at second and third
floor (p < 0.05). The annual effective dose of all studied schools at 4
different cases of ventilation were found less than the worldwide average
radiation dose of 3-10 mSv. So, it is not required to take any action to
minimize the level of radon in schools under study.
Errata
Authors: Editorial E
Published: August 2023

In the articles THERMAL-HYDRAULIC ANALYSIS OF LIGHT WATER REACTORS UNDER
DIFFERENT STEADY-STATE OPERATING CONDITIONS Part 1 - Boiling Water Reactor
by Ezddin HUTLI 1 and Ramadan KRIDAN 2 and THERMAL-HYDRAULIC ANALYSIS OF
LIGHT WATER REACTORS UNDER DIFFERENT STEADY-STATE OPERATING CONDITIONS Part
2 - Pressurized Water Reactor by Ezddin HUTLI 1 and Ramadan KRIDAN 2
published in the journal Nuclear Technology & Radiation Protection, 37
(2022), 4, pp. 259-275, and pp. 276-288, the authors' affiliations are
incompletely listed. In both articles, the affiliations should have read as
follows: Ezddin HUTLI 1,2 and Ramadan KRIDAN 3 1 Centre for Energy
Research (CER), Budapest, Hungary 2 Institute of Nuclear Techniques,
Budapest University of Technology and Economics, Budapest, Hungary 3
Department of Nuclear Engineering, Faculty of Mechanical Engineering,
Al-Fattah University, Tripoli, Libya Editorial Board offers an apology for
this mistake to the articles' writers and the readers of the Nuclear
Technology & Radiation Protection journal.

 Link to the corrected article 10.2298/NTRP2204259H

 Link to the corrected article 10.2298/NTRP2204276H
Dampak Kompetensi Pedagogik terhadap Kemampuan Berpikir Kritis pada Siswa Kelas V SD
Authors: Nuzulaeni Ine , Susanto Ratnawati
Published: August 2023

Rendahnya kemampuan awal berpikir kritis siswa dalam menjawab pertanyaan terbuka dan kurangnya penerapan literasi maupun pojok baca yang ada di lingkungan sekolah. Jenis penelitian ini adalah penelitian kuantitatif dengan menerapkan metode survey dan pendekatan korelasional. Penelitian ini dilakukan dengan menggunakan teknik angket. Subjek penelitian adalah Kepala Sekolah, Wakil Kepala Sekolah dan Guru sejumlah 30 orang pada variabel kompetensi pedagogik. Pada variabel kemampuan berpikir kritis melibatkan siswa kelas V A masing-masing sebanyak 30 siswa yang sebelumnya telah dilakukan uji coba instrumen dengan melibatkan siswa kelas V B sebanyak 30 siswa. Teknik analisis data menggunakan analisis kuantitatif. Hasil analisis menunjukkan bahwa kompetensi pedagogik terhadap kemampuan berpikir kritis memiliki korelasi sebesar 0,823 atau 82,3%. Pada hasil (uji-t) diperoleh t-hitung = 7,665 > t-tabel = 2,052. Hasil ini menunjukkan H0 ditolak dan H1 diterima yang artinya bahwa kompetensi pedagogik memiliki hubungan secara positif dan signifikan dengan kemampuan berpikir kritis. Implikasi penelitian ini diharapkan memberikan dukungan dan peluang kepada guru untuk menciptakan proses pembelajaran yang berinovasi dengan memberikan pelatihan dan workshop sebagai bekal guru dalam mencapai tujuan pendidikan serta menghasilkan siswa yang berprestasi.
Media Komik Literasi Berbasis Kontekstual Materi Hak dan Kewajiban Muatan PPKn Kelas V Sekolah Dasar
Authors: Wulandari Luh Putu Mekar , Suniasih Ni Wayan
Published: August 2023

Kurangnya ketersediaan buku tematik yang menyebabkan siswa kurang dapat memahami materi pembelajaran dengan baik. Penelitian ini bertujuan untuk mengembangkan media komik literasi bebasis kontekstual materi hak dan kewajiban muatan PPKn kelas V sekolah dasar. Dalam penelitian ini model penelitian pengembangan yang digunakan yaitu model ADDIE. Subjek dalam penelitian ini merupakan 1 dosen yang memiliki kualifikasi dibidang Teknologi Pendidikan, 1 dosen yang memiliki kualifikasi dalam mata pelajaran PPKn, 3 orang untuk uji coba perorangan dan 9 orang untuk uji coba kelompok kecil. Untuk pengumpulan data pada penelitian ini menggunakan metode non tes berupa observasi, wawancara dan penyebaran angket dengan instrument angket. Setelah data terkumpul dilakukan analisis dengan teknik analisis data deskriptif kuantitatif dan deskriptif kualitatif. Hasil uji kelayakan pada media komik literasi mendapatkan persentase 92,18% untuk ahli media pembelajaran dan 97,91% untuk ahli isi pembelajaran dengan kualifikasi sangat baik. Sedangkan untuk ahli desain pembelajran mendapatkan persentase 89,58% dengan kualifikasi baik. Untuk uji coba perorangan dan uji coba kelompok kecil mendapat persentase masing-masing 90,14% dan 94,41% dengan kualifikasi sangat baik. Jadi, media komik literasi berbasis kontekstual materi hak dan kewajiban muatan PPKn kelas V layak digunakan dalam kegiatan pembelajaran.
E-Book Berdasarkan Model Pembelajaran Berbasis Proyek pada Mata Kuliah Media Pembelajaran
Authors: Simamora Alexander Hamonangan , Jampel Nyoman , Tegeh I Made
Published: August 2023

Bahan ajar yang dipergunakan masih terbatas pada buku ajar cetak yang selama ini memiliki banyak keterbatasan. Hal ini berdampak pada kurangnya motivasi mahasiswa dalam belajar dan berpengaruh pada hasil belajar yang rendah. Tujuan penelitian ini yaitu mengembangkan E-book berbasis proyek pada mata kuliah media pembelajaran. Penelitian ini merupakan penelitian pengembangan yang merujuk pada model pengembangan ADDIE (Analysis, Desain, Development, Implementation, Evaluation). Subjek penelitian ini yaitu 2 orang ahli yang meliputi ahli media pembelajaran dan desain pembelajaran. Subjek uji coba produk yaitu 3 orang mahasiswa sebagai subjek uji perorangan, 12 mahasiswa (kelompok kecil). Metode pengumpulan data menggunakan observasi, kuesioner, dan tes. Instrument yang digunakan dalam mengumpulkan data yaitu kuesioner. Teknik yang digunakan untuk menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu penilaian yang diberikan oleh ahli media pembelajaran E-book berbasis proyek memperoleh nilai persentase 97,5% (sangat baik). Hasil penilaian yang diberikan oleh ahli desain pembelajaran   yaitu 95,4% (sangat baik). Hasil penilaian uji coba perorangan yaitu 90% (sangat baik). Hasil penilaian uji coba kelompik kecil yaitu 93,7% (sangat baik). Dapat disimpulkan bahwa E-book berbasis proyek pada mata kuliah media pembelajaran layak digunakan dalam pembelajaran. Dosen dapat menggunakan E-book berbasis proyek untuk meningkatkan semangat belajar mahasiswa.
Management of Blended Learning and Digital Skills and Their Influence on the Learning Independence of Vocational Students
Authors: Patabang Apriani , Mesta Limbong  , Tarsicius Sunaryo
Published: August 2023

Changes in the implementation of learning due to the Covid 19 pandemic impact learning methods, so teachers and students must be able to adapt to online learning policies. This study analyzed the effect of blended learning management and digital skills on student learning independence. This type of research is ex post facto research, namely comparative causal research. The population in this study were all vocational school teachers, with a total sample of 103 respondents. Data collection was carried out by distributing instruments in the form of questionnaires. Data analysis techniques are correlation and regression. The results of the data analysis show that the model, namely the teacher's blended learning management and digital skills, can explain variations in student learning independence. The R square value of 0.589 indicates that the model, namely X1 and X2, can explain the variation in Y of 58.9%. Based on these results, teachers must implement blended learning management optimally and be supported by developing students' digital skills to increase learning independence. The implications of this research can be used as input, reference, and discourse on students' independent learning about blended learning management and digital skills.
Design Principles of Learning Messages in E-Learning
Authors: Rama Faiz Pangestu  , Herman Dwi Surjono
Published: August 2023

Some things still need more attention in the content or messages contained in e-learning. Therefore, good message planning or arrangement is needed concerning the principles of learning message design. This scientific study aims to analyze the application of learning message design principles in e-learning media. This study uses a qualitative descriptive approach with the type of research that is descriptive content analysis. The stages of content analysis research include formulating analysis objectives, conceptualization, and operationalization, coding sheet or instrument grids, population and sample determination, coding process, data input, and analysis. Data collection in the research was carried out using the document study method, with the research instrument in the form of coding sheets based on the definition of applying the principles of learning message design. The data analysis technique uses descriptive qualitative analysis. The results of the research analysis show that the contents of the message illustrate that in e-learning besmart, the e-learning development course has applied the principles of readiness and motivation, the principle of using the object of focus of attention, the principle of student participation, the principle of iteration, and the principle of feedback. However, it has not implemented the initial ability test as a form of readiness principle.