bluuebunny/crossref_metadata_2025 huggingface dataset:
RNA-sequencing comparison of pneumonectomy and bleomycin reveals anti-fibrotic mechanisms of lung fibroblasts
Authors: Wellmerling Jack H , Dresler Sara R , Meridew Jeffrey A , Choi Kyoung M , Haak Andrew J , Tschumperlin Daniel J , Tan Qi
Published: December 2022

Background
Idiopathic pulmonary fibrosis (IPF) is characterized by pathological accumulation of scar tissue in the lung parenchyma. Many of the processes that are implicated in fibrosis, such as matrix deposition also occur following pneumonectomy (PNX). However, fibrosis does not occur. Since fibroblasts are the major cell type responsible for extracellular matrix production, we hypothesized that comparing their responses to PNX and bleomycin (BLM) would unveil key differences in the role they play during regulated and fibrotic lung growth.
Methods
RNA-sequencing was performed on flow cytometry-sorted fibroblasts from mouse lungs 14 days after bleomycin challenge, PNX, or sham. Pathway and transcription factor binding motif enrichment analysis were performed to characterize RNA-sequencing data. Normal human lung fibroblasts (NHLFs) were used as a cell culture model to validate targets.
Results
RNA-sequencing analysis revealed similar biological processes to be involved in both responses, including signaling by transforming growth factor-β (TGF-β1) and tumor necrosis factor-α. Transcription factor binding motif enrichment predicted erythroid transformation specific (ETS) superfamily members to play a key role in the response to BLM, whereas nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) were predicted to orchestrate much of the response to PNX. Itpkc, encoding inositol triphosphate kinase C, was a gene uniquely up-regulated by PNX and a likely AP-1 target. ITPKC overexpression in NHLFs antagonized the fibrotic effect of TGF-β1. RNA-sequencing analysis of primary NHLFs overexpressing ITPKC further supported its role in repressing collagen production and predicted it as an activator of canonical NF-κB signaling. ITPKC overexpression showed considerable overlap with the innate immune signaling seen following PNX.
Conclusion
Taken together, our RNA-sequencing analysis suggests that during post-PNX lung growth, AP-1 activates ITPKC to promote canonical NF-κB signaling to prevent fibrogenesis. Future studies to understand this lack of ITPKC induction during fibrotic injury may identify attractive therapeutic targets.
WITHDRAWN: Growth, Structural, Spectral, Quantum Chemical Analysis, first and second order hyperpolarizabilities and molecular Docking Study of Ammonium P- Toluenesulfonate
Authors: BOUKABCHA Nourdine , GANDHI Saravana Kumar , BELHACHEMI Mohammed hadj Mortada , MURUGAN Jeyalaxmi , AZAYEZ Mansour
Published: December 2022

In this work, Ammonium p-Toluenesulfonate (AMPTS) were studied theoretically and compared to experimental data. The density functional theory (DFT) method was employed to study the optimized structure using the basis set B3LYP/6–311G (d,p). DFT studies have shown strong concordance between Fourier Transform Raman, Infrared and UV-visible spectroscopic data and experimental results. The calculated energy gap of HOMO-LUMO, DOS and MEP surface, has showed that the charge transfer take place in the AMPTS molecule. The calculated global chemical reactivity descriptors have revealed that our title molecule possesses an elevated electrophilic character, as proved by its value (2.713 eV). The rise in temperature leads to an increase in thermodynamic parameters. Moreover, analysis of first and second order polarization has shown considerable potential for use in NLO applications. Hirshfeld surface has revealed the percentage contribution of the most dominant interactions as H⋯O/O⋯H, H⋯H and C⋯H/H⋯C. Finally, Molecular docking of AMPTS ligand with Feruloyl Esterase for the treatment of plant diseases.
FMR in thin films with finite extension
Authors: Fuentes G. P. , Silva D. B. O. , Padrón-Hernández E.
Published: December 2022

Ferromagnetic resonance (FMR) by micromagnetic simulation was carried out in Py circular-shaped films with 2 µm area and thickness of 50 nm. Another geometry with stadium-like format (1 µm of minor axes and 4 µm of major axis) was studied. Ferromagnetic resonance by simulation with an in plane and perpendicular external magnetic field show differences in results if compared the two geometries. The results are relevant, as the dimensions of these objects present an aspect ratio of more than 20 times (side dimension/thickness). The results are quite different as the magnetization maps are different for the two geometries. Even working in the field enough to saturate the material. Analyzes were performed using Kittel's equations for FMR.
Evaluation of oxidant and antioxidant status in naturally infected Indian water buffalo (Bubalus bubalis) with liver cystic echinococcosis
Authors: Aslam Humera , Bi Sabiha , Irshadullah Malik
Published: December 2022

The present study aims to evaluate the changes in the antioxidants and oxidant status of buffalo, naturally infected with cystic echinococcosis. Infected and non-infected livers were used to determine the level of oxidative stress markers, antioxidant and pathological marker enzymes. A significantly higher level of glutathione-s-transferase (GST) and glutathione peroxidase (GPx), while a significantly low level of glutathione reductase (GR), thioredoxin reductase (TR) was observed in the parasitized than the healthy liver. Reduced glutathione (GSH), a key non-enzymatic antioxidant, was found less in the infected than in the non-infected liver. The hydatid cysts infection is accompanied by the enhanced production of ROS with subsequent elevation of lipid peroxidation and protein oxidation, as evident from increased malondialdehyde (MDA) and protein carbonyl (PC) respectively. Enhanced MDA disrupts the cell membrane leading to the release of marker enzymes (AST, ALT, ACP, and ALP) of liver damage due to mechanical pressure and the space-occupying affect of hydatid cysts. Alteration in the level of antioxidants and oxidative stress markers provide reliable evidence for the circulating oxidative stress in the infected buffalo
Tropheryma Whipple dystrophy and Nocardia infection associated with lung tumor: a case report and literature review
Authors: Zhou Yuli , Yang Nan , Ruan Senlin , Wu Shenghai , Yu Daojun , Jin Juan
Published: December 2022

Tropheryma whipplei (TW) and Nocardia are rare pathogenic bacteria found in the clinic. Under the action of some immune mechanisms, TW-induced Whipple dystrophy may develop to the Whipple disease. Increasing studies have demonstrated their etiological characteristics and the epidemiology, pathogenesis, diagnosis, and treatment of the diseases they cause. We present a case of a patient with a lung tumor associated with TW and Nocardia co-infections. The final diagnosis was confirmed by tissue biopsy, PCR, and gene sequencing. Clinical features of this case are discussed, including TW diagnosis process, morphological characteristics of infection, and its relationship with tumor, as well as a review of previous studies on the Whipple disease.
Numerical Experiments on Ion-Beam Features Emitted from Different-Energy DPF Devices for Deuterium Gas
Authors: Altarabulsi A. , Abou-Ali Y. , Salo S. Alsheikh , Akel M. , Lee S. , Marciniak L.
Published: December 2022

In this study, numerical experiments on ion beam features emitted from nine Dense Plasma Focus devices were carried out using the Lee model code (version RADPFV5.16FIB). A simulation (numerical experiment) and connected fitting procedure of a total discharge current waveform was presented on the example of the PF-24 device, and summary data concerning simulations and fitting procedures for each device were presented. The full details of the ion beam properties as a function of pressure for the PF24 device were presented. The properties of deuterons such as flux, fluence, flux energy, fluence energy, current density, ion current, damage factor, and energy of deuterons versus pressure were computed and investigated. A comparison between the properties of deuterons computed at fitted pressure and at a pressure where the flux is the highest was presented and discussed according to equations on which the Lee model is based.
Juvenile ossifying fibroma in adult patient: a rare case report
Authors: Sh Milad Etemadi , Teimoori Farshad , Razavi Seyed Mohammad , Tajmiri Golnaz , Noghabaee Alireza , Sehat Mohammad Soroush
Published: December 2022

Juvenile ossifying fibroma of the jaws is an aggressive variant of ossifying fibroma that tends to affect children and adolescents. Early detection and immediate treatment are essential for this condition due to its different clinical behavior, highly aggressive nature, and high tendency for recurrence. Our report describes a case of juvenile ossifying fibroma in a 27-year-old woman who presented with swelling on the left side of the face, with typical clinical, radiological, and histological features. The patient underwent surgery to remove the lesion, and after resection of the involved area, no further symptoms were reported in the follow-up sessions. CBCT scans and panoramic imaging of the patient 6 months after surgery revealed no radiographic sign of recurrence. Autologous iliac crest grafting was performed for reconstruction of the resected area.
Machine Learning vs. Rule-Based Methods for Document Classification of Electronic Health Records within Psychiatry - A Systematic Literature Review
Authors: Rijcken Emil , Zervanou Kalliopi , Mosteiro Pablo , Scheepers Floortje , Spruit Marco , Kaymak Uzay
Published: December 2022

Throughout the history of artificial intelligence, various algorithm branches have predominantly been used at different times. The last decade has been characterized by a shift from rule-based methods to self-learning methods. However, while the shift towards using ML methods is evident, there is no comparison of both methods for document classification. This systematic literature review focuses on the document classification in healthcare notes from electronic health records within psychiatry. We assess how these methods compare to each other in terms of classification performance and how they have developed throughout time, and we discuss potential directions of the field. We find that rule-based methods have had a higher performance for most of the last decade than machine-learning methods.Yet, the shift in representation techniques and algorithms used in recent years resulted in machine learning methods performing better.Dense document representation techniques, with mostly non-zero cells, outperform sparse representation techniques, with mostly zeros. Also, many neural networks outperform other self-learning- and rule-based methods. We find that state-of-the-art language models are barely employed in the psychiatric domain and expect an increase in the application of federated learning can increase the data availability for model training.
Rapid Point of Care Testing for Sexually Transmitted Infections Using a Portable Isothermal Loop Mediated Nucleic Acid Amplification Platform
Authors: Germaner Ece T. Esitgen , Wassill Lars , Dichtl Karl , Roider Julia , Seybold Ulrich
Published: December 2022

Purpose
To analyze sensitivity and specificity of the rapid point-of-care (POC) eazyplex STD complete testing platform for sexually transmitted infections (STI) among men who have sex with men (MSM).
Methods
272 anal, urethral, and pharyngeal swabs collected from 153 MSM were tested by both eayzplex STD complete and the university microbiology laboratory.
Results
Compared to the reference diagnostic method, the overall sensitivity/specificity of STD complete was 88%/98% for N. gonorrhoeae, 82%/100% for C. trachomatis, 70%/>99% for U. urealyticum, and 85%/98% for M. hominis, respectively. Sensitivity for N. gonorrhoeae and U. urealyticum in urethral samples was 100%.
Conclusion
With good to excellent sensitivity depending on sampling site and pathogen as well as excellent specificity overall eazyplex STD complete is a useful rapid diagnostic method for POC STI-testing especially for N. gonorrhoeae and C. trachomatis, allowing for almost immediate treatment initiation.
Effect of Pomegranate (Molasses, White Peel and Red Peel) extract on healthy liver and hepatotoxicity induced by Phenylhydrazine in male rats
Authors: Soliman Nabil Abbas , Mansour Sherif Wajih , Ammar Mohammed Ahmed , Ammar Mohamed Ahmed Mohamed
Published: December 2022

Pomegranates (Punica granatum L.) are said to provide various health advantages, according to accumulating research. The Liver tissue and antioxidant stress effect of pomegranate molasses, white and red peel extracts on male rats with phenylhydrazine (PHZ)-induced anaemia are highlighted in this article. Phenylhydrazine induced anemia resulted in: Decreasing of Direct Bilirubin, CAT, GPx, SOD, ALP, Accompanied by increasing of LDH, Total Bilirubin, Indirect Bilirubin, MDA, ALT, AST. Regarding the histopathology study of Liver: PHZ exposed group showed a loss of the normal architecture with dilated, congested central vein and necrotic areas, dilated and congested blood sinusoids with pycnotic Kuppfer cells and hepatocytes with karyolytic nuclei. PHZ exposed group showed a severely-vacuolated hepatic environment with hydrobic degeneration apoptotic and degenerated hepatocytes, focal necrosis, dilated blood sinusoids with atrophied Kuppfer cells and dilated central vein. Regading of Molasses Pomegranate + PHZ; White Peel Pomegranate + PHZ and Red Peel Pomegranate + PHZ (Improvement Group): There was an increase of Direct Bilirubin, CAT, GPx, SOD, ALP. Accompanied by decreasing of LDH, Total Bilirubin, Indirect Bilirubin, MDA, ALT, AST, ALP. Red peel pomegranate after PHZ (Red Peel + PHZ) exposed group showed a partial restoration of the normal histological pattern to a great extent with a central vein having a good profile and hepatocytes with healthy and intact nuclei. But some vacuolization and leucocytic infiltration is still evident. White peel pomegranate after PHZ (White Peel + PHZ) exposed group showed a regeneration in hepatocytes, a nearly normal blood sinusoids, but the central vein is still congested and surrounded with damaged cells. Molasses pomegranate after PHZ (Molasses + PHZ) exposed group showed most of hepatocytes and Kuppfer cells taking normal appearance but the hepatic environment is still vacuolated (V) and the central vein is congested. Conclusion: Molasses, White peel and Red peel Pomegranate have a strong antioxidant for protective liver tissue.
The effect of pelvic floor muscle training in women with functional bladder outlet obstruction
Authors: Tzelves Lazaros , Tsikopoulos Ioannis , Sakalis Vasileios , Papathanasiou Christina , Samarinas Michael
Published: December 2022

Introduction and Hypothesis
Female voiding dysfunction is often due to bladder outlet obstruction (BOO). We investigated pelvic floor muscle training (PFMT) effectiveness in women with functional BOO.
Methods
This is a prospective study recruiting 63 women functionally obstructed, over 18yo, maximum flow rate (Qmax) less than 12ml/sec, naïve of voiding treatment. Exclusion criteria were anatomical BOO, neurological condition, pelvic intervention, psychiatric or anticholinergic medication, diabetes mellitus and affected upper urinary tract. At baseline, women underwent uroflow, post void residual (PVR) measurement, cystoscopy, cystogram and urodynamic study (UDS) with pelvic electromyography (EMG). Blaivas-Groutz nomogram has been used to define obstruction. After diagnosis, patients underwent six-month PFMT. Re-evaluation was offered four weeks after end of treatment. Data were analyzed with SPSSv22.0.
Results
63 women were recruited and 48 finally included. At baseline, 20 reported 3 urinary tract infections (UTIs) during last year, and 12 had one episode of urine retention. Median Qmax was 7.5ml/sec and median PVR 110ml. 40 women were obstructed. 16 (40%) had mild, 16 (40%) moderate and 8 (20%) severe obstruction. All subjects had an overactive pelvic floor on EMG.
Obstructed women were re-evaluated. Median Qmax was 8.5ml/sec, close to baseline (p= 0.16). Median PVR was 65ml, reduced to baseline (p= 0.02). 33 (82.5%) remained obstructed, 22 (66.67%) with mild, 8 (24.24%) moderate and 3 (9.09%) severe obstruction. 7 (17.5%) were non-obstructed. 4 patients reported one UTI episode with no cases of retention.
Conclusions
A six-month PFMT reduced UTIs and PVR in women with functional BOO. Additionally, most patients had a de-escalation to milder obstruction.
Health Providers’ Perspectives on Quality of Adolescent Mental Health Services in Low- Resource Settings: a qualitative study in São Paulo City, Brazil
Authors: Quinlan-Davidson Meaghen , Devakumar Delan , Mannell Jenevieve , Peres Maria Fernanda , Kiss Ligia
Published: December 2022

Background: Quality in adolescent mental health services is instrumental to adolescents accessing and continuing care. There has been a growing interest and investment in adolescent mental health services, yet evidence on their quality remains inadequate, particularly in limited resource settings such as São Paulo city, Brazil. Health services in these settings experience a lack of financial and human resources. Adolescents within these settings are often exposed to poverty, community violence and limited access to resources and essential services; all of which contribute to the development of mental health conditions. The objective of the study was to explore health care providers definition of quality, as well as barriers and enablers to adolescent mental health services within resource-limited settings of São Paulo city, Brazil.
Methods: Health care providers were purposively sampled in five primary health care facilities and two specialised mental health facilities, predominantly in the southwest zone of São Paulo city. Semi-structured interviews among 45 health care providers were conducted. Thematic analysis was used to explore their narratives.
Results: No standardised definition of quality in adolescent mental health services emerged in the interviews. Definitions of quality revolved around a social determinants of mental health perspective; and aspects of service organisation including a trained, multidisciplinary workforce and person-centred care. These definitions were ideal and impossible to realise due to barriers identified by the health care providers, including underfunded and overburdened systems of care; the prioritisation of other age groups as set out by the primary care mandate; and the social and environmental context which adversely affected the provision of care. Ultimately, this resulted in the neglect of the adolescent by the health system.
Conclusions: This is the first study to investigate health care providers’ definition of quality in adolescent mental health services in Brazil and in low-resource and violent settings. Based on health care providers’ definitions, a social determinants of health approach, in combination with a trained workforce and person-centred care, is key to addressing quality in adolescent mental health services. The findings have implications for local conceptualisations of quality, barriers to adolescent mental health services and reducing the treatment gap.
Liner shipping hub location and empty container repositioning: Use of foldable containers and container leasing
Authors: Wang Qian , Zheng Jianfeng , Lu Bo
Published: December 2022

Considering the influence of economies of scale and ship capacity on empty container repositioning, using foldable containers and container leasing may be effective ways to save the operating costs of liner shipping companies. Considering the minimization of the transportation costs of empty and laden containers, this paper studies a liner shipping hub location problem with empty container repositioning (LSHLPECR) considering foldable containers. We propose a mixed integer linear program (MILP) for the formulation of the LSHLPECR. In terms of the optimal solution of our MILP, this paper further explores the container leasing pricing problem (CLPP), where our aim is to obtain perceived container leasing prices (PCLPs) utilizing the inverse optimization technique. Numerical experiments verify the effectiveness of the studied problems.
Frequency of MVP and Congenital Heart Disease in Children with Pectus Chest Wall Deformity: Five-Years of Experience
Authors: Karabulut Muhammed
Published: December 2022

Pectus anomalies constitute 95% of chest anomalies. Pectus carinatum (PC) and excavatum (PE) are often asymptomatic in childhood. However, symptoms and signs such as chest pain, dyspnea and mitral valve prolapse (MVP) can be seen in pectus anomalies. Demographic characteristics and accompanying cardiac signs in children with pectus deformity were investigated. In this study, the clinical findings of children with pectus deformity and the frequency of MVP and other concomitant heart diseases detected in echocardiographic examinations were evaluated. Eighty-two PE, 27 PC, and 107 healthy children were included in this study. In the echocardiographic examination of PE, PC patients and healthy children, MVP was detected with a frequency of 25%, 33% and 2% respectively. The study showed that pectus anomalies were associated with an increased frequency of MVP. Therefore, all patients with pectus deformity should undergo a screening echocardiogram in adolescence to assess for presence of MVP.
Impact of the amount of the gold layer on the tribological performance of the ceramic conversion treated CP-Titanium
Authors: Zhang Zhenxue , Yu Hao , Li Xiaoying , Dong Hanshan
Published: December 2022

Titanium alloys are characterised by poor tribological properties, and a ceramic TiO2 layer formed on the surface can greatly improve its performance. By pre-depositing a gold layer on the titanium surface, the gold particles promote the outward diffusion of titanium in the ceramic conversion treatment to react with the inward-coming oxygen to form a compact titanium dioxide layer. The surface morphology, microstructure, phase constituents were characterised by SEM/EDX and XRD. The adhesion o the oxide layers were assessed by a scratch test. The distribution of gold particles in the oxide layer can enhance the surface hardness and reduce friction and wear against a WC ball in the reciprocal tribological test. The ceramic conversion process can be accelerated efficiently at 620-660°C, and the more gold pre-deposited, the thicker the oxide layer.
Adsorption characteristics of Penicillium amphipolaria XK11 to cadmium and antimony
Authors: Jingyi Dai , Chaoyang Li , Yu Sun , Yunlin Zhao , Huimin Huang , Yingzi Ma , Zhenggang Xu
Published: December 2022

Heavy metal pollution is a worldwide problem that harms both the environment and human health. Wherein, microorganisms play important roles in remediation process. In this study, a strain XK11 with high resistance to both antimony Sb(III) and cadmium Cd(II) was screened from the mineral slag and was identified as Penicillium amphipolaria by molecular identification. The strain was resistant to heavy metals Cd and Sb, and had a high phosphate solubilization capacity. The results showed that the removal rate of XK11 to Cd and Sb solution could reached 45.6% and 34.6% respectively. When initial pH0 and adsorption time constant, XK11 could achieve the maximum removal rate of heavy metals Cd and Sb under different initial heavy metal concentration. The initial heavy metal concentration had a greater influence on biosorption than the initial pH0 and adsorption time. The findings demonstrated the potential of XK11 in the remediation of heavy metal Cd and Sb pollution, identifying potential materials and treatment strategies for heavy metal remediation.
Disease Severity Classification using Passively Collected Smartphone-Based Keystroke Dynamics within Multiple Sclerosis
Authors: Hoeijmakers Aleide , Licitra Giovanni , Meijer Kim , Lam Ka-Hoo , Molenaar Pam , Strijbis Eva , Killestein Joep
Published: December 2022

Multiple Sclerosis (MS) is a progressive demyelinating disease of the central nervous system characterised by a wide range of motor and non-motor symptoms. The level of disability of people with MS (pwMS) is based on a wide range of clinical measures, though their frequency of evaluation and inaccuracies coming from objective and self-reported evaluations limits these assessments. Alternatively, remote health monitoring through devices can offer a cost-efficient solution to gather more reliable, objective measures continuously. Measuring smartphone keyboard interactions is a promising tool since typing and, thus, keystroke dynamics are likely influenced by symptoms that pwMS can experience. Therefore, this paper aims to investigate whether keyboard interactions gathered on a person’s smartphone can provide insight into the clinical status of pwMS leveraging machine learning techniques. In total, 24 Healthy Controls (HC) and 102 pwMS were followed for one year. Next to continuous data generated via smartphone interactions, clinical outcome measures were collected and used as targets to train four independent multivariate binary classification pipelines in discerning pwMS versus HC and estimating the level of disease severity, manual dexterity and cognitive capabilities. The final models yielded an AUC-ROC in the hold-out set above 0.7, with the highest performance obtained in estimating the level of fine motor skills (AUC-ROC=0.753). These findings show that keyboard interactions combined with machine learning techniques can be used as an unobtrusive monitoring tool to estimate various levels of clinical disability in pwMS from daily activities and with a high frequency of sampling without increasing patient burden.
Complication Severity and Its Association with the COVID-19 Prevention, Management and the Place of Treatment of the COVID-19 Patients in Bangladesh: A Cross-Sectional Study
Authors: Hossain Syed Billal , BakiBillah Abul Hasan , Muhammad Faisal
Published: December 2022

This study aimed to explore the extent of COVID-19 complications and its association with the pattern of COVID-19 management and prevention at hospital and home settings in urban Bangladesh. The study included 659 COVID-19 positive patients aged 18 and up who were treated at home or in hospitals and lived in Dhaka city from April to September 2021. Among the respondents, around 79% respondents suffering from mild infection believe that the risk of Covid-19 infection can be decreased by wearing mask, while 21% participants with severe infection had similar opinion and have significant association of wearing masks with infection level (p < .001). The predominant primary symptoms of COVID–19 infection was fever (80.9%), dry cough (60.4%), myalgia (56.6%), headache (50.5%), sneezing (38.2%), chest pain (25.9%), diarrhea (23.2%) and loss of smell/taste (21.5%). About 61.8% participants did not suffer from any co-morbidity. Others suffered mostly from diabetes (22.9%), cardiovascular disease (19.7%) and asthma/COPD (7.9%) as co-morbidities. 80.9% respondents having mild infection and 19.1% having severe infection always practiced all preventive measures as wearing masks, used alcohol-based hand rub and using PPE at workplace to avoid Covid-19 infection. The reported post-recovery symptoms are fatigue/muscle weakness (42.3%), headache (39.3%), loss of taste/smell (29.0%), depression (27.2%), cough (25.8%), breathing difficulty (21.1%), trouble in mobility (19.7%), chest pain (19.4%), loss of memory (18.1%), each of joint pain/arthralgia and fever (17.0%) and weight loss (16.4%). Recovery time was found to be significantly influenced by family income, the number of co-morbidities, and the location of therapy. Furthermore, age, the number of co-morbidities, and educational level were all strongly linked to the treatment location. Government needs to emphasize more on making sure the effective level of management at the hospitals and extensive level of awareness at the community level where concerted efforts is inevitable.
Enzyme PTP-1B Inhibition Studies by Vanadium Metal Complexes: A Kinetic Approach
Authors: Shaik Ayub
Published: December 2022

The medical field now needs more novel drugs to treat obesity and type-2 diabetes mellitus (T2D) than ever before. Obesity and T2D are both characterized by resistance to the hormones leptin and insulin. PTP-1B is a promising target for drug growth as strong genetic, pharmacological and biochemical evidence points to the possibility of treating diabetes and obesity by blocking the PTP-1B enzyme. Studies have also found that PTP-1B is over expressed in patients with diabetes and obesity, suggesting that inhibiting PTP-1B may be a useful technique in their care. There aren't any clinically used PTP-1B inhibitors, despite the fact that numerous naturally occurring PTP-1B inhibitors demonstrated great therapeutic promise. This is most likely because of their low activity or lack of selectivity. It is still important to look for more effective and focused PTP-1B inhibitors. A few organo vanadium metal complexes were synthesized, characterized, and binding studies on vanadium complexes with PTP-B were also performed using Fluorescence Emission Spectroscopy. Additionally, we theoretically (molecular modeling) and experimentally (enzyme kinetics) examined the PTP-1B inhibitory effects of these vanadium metal complexes and found that they have excellent PTP-1B inhibitory properties.
Quantum Signature of Anisotropic Singularities in Hydrogen Bond Breaking of Water Dimer
Authors: Ali Md. Rejwan
Published: December 2022

In a recent paper, via three different semi-empirical methods, we reported quantum singularities of molecular electronic energies as signature of chemical bond break-up process in Rivastigmine drug molecule with torsion angle variation around -CO- bond revealed broken chemical moieties of Rivastigmine under experimental X-ray structure identification. In this present work, applying first principle methods of Hartree-Fock, Density Functional as well as Moller-Plesset techniques. we have reconfirmed the previous general predictions of singularities in molecular electronic energy with torsion angle variation around weak H-bond of water dimer. Due to quantum nature of chemical bond breaking process leading to break-point conditions in otherwise connected molecular topology, the singularities in electronic energy is also suggestive of classical large force as needed in bond-breaking process onset. In this paper, we have presented the details of these interesting findings studied on water dimer. These results of quantum singularities can be useful to improve current force field and to understand reaction chemistry involving bond-breaking under geometrical constrains.
Preparation and Evaluation the Efficacy of Combined Mixture of Finger Root and Robusta Coffee Extracts on Antioxidative Activity
Authors: Kitsomchip Chotirod , Indranupakorn Ratana
Published: December 2022

Finger Root (FR) and Robusta Coffee (RC) are natural substances known to be beneficial for human health and used as a traditional medicine in various parts of the world. The efficacy of two commonly used extraction techniques [Ultrasound-Assisted Extraction (UAE) and maceration with stirring (MR)] and four different extraction solvents (50% ethanol, 80% ethanol, 100% ethanol and acetone) on antioxidant activity and the Total Phenolic Content (TPC) in both herbs were investigated. The antioxidant potentials of the samples were determined by reducing capacity with Folin-Ciocalteu reagent, while the radical scavenging activity using 1,1-Diphenyl2-Picryl Hydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothia zoline-6-sulfonic acid) (ABTS) assays. FR and RC extracts from UAE and using 80% and 50% ethanol as an extraction solvent, respectively, showed the highest antioxidant capacity compared to the other extraction processes. The combined mixtures of FR and RC (CFR) in the weight ratios of 1:1 was prepared and evaluated the antioxidant activity. The CFR extract showed a significant increase of TPC and resulted in its strong radical scavenging activity, quite the same level in comparison to the model antioxidant substance, ascorbic acid, compared to when they were assayed independently. Stability results indicated that the TPC of CFR extract was slightly decreased, by around 8.7% and the IC50 values of CFR extract showed slightly increased from 7.13 to 9.06 µg/mL in DPPH assay and from 725.72 to 858.65 µg/mL ABTS assay after storage at room temperature over 1 month. Findings suggested that the extraction methods and different solvent polarity significantly affect polyphenol recovery. The combined mixture of FR and RC extracts, which is quite stable and enhances radical scavenging activity, is interesting to increase economic value and utilization in cosmetic industry.
A CASE SERIES ON OLFACTORY NEUROBLASTOMA
Authors: Ranjit Kumar D. , Radhakrishnan K.R. , Balasubramani J.
Published: December 2022

Olfactory neuroblastoma (ON), also called Esthesioneuroblastoma (ENB) is a rare malignant nasal tumour that arises from the olfactory neuroepithelium in the olfactory rim of nasal cavity. Here, we present a case series of two patients who presented with nasal obstruction, epistaxis and anosmia. Clinical examination revealed reddish mass within the nasal cavity and extending into the nasopharynx. An endoscopic craniofacial resection was done and biopsy confirmed the masses to be olfactory neuroblastoma.
PREVALENCE OF BODY DYSMORPHIC DISORDER AMONG FEMALE PATIENTS SEEKING COSMETIC PROCEDURES
Authors: F. Almuhanna Norah , M. Alghamdi Wesam , T. Zainalabedin Ahmad , A. Alghamdi Abdulrahman , H. Abed Faisal , T. Algaidi Marwan , A. Mohamed Ahmed
Published: December 2022

Body dysmorphic disorder (BDD) is a psychiatric illness in which individuals with minimal or non-existent defects related to appearance worry immensely about their looks:which results in displaying significant distress and impairment in behavior and psychosocial functioning. Patients with BDD seeking cosmetic surgery are usually unsatisfied with the outcomes of the surgery. Therefore, it is important to study this phenomenon and increase awareness among physicians about the importance of assessing their patients before starting any cosmetic treatment. To assess the presence of BDD in patients undergoing cosmetic procedures, and to improve the awareness about BDD among providers of cosmetic treatment. This is a cross-sectional study that uses the adult version of the BDD modification of the Y-BOCS (BDD-YBOCS) scale. This scale consists of 12 items related to preoccupied thoughts that participants have about their appearance, and the effects that these thoughts have on their lives. In this study, participants were instructedto answer questions on a 5-point Likert-type scale. Questionnaires were distributed on different online platforms, among females living in the eastern province of Saudi Arabia. Out of these, responses were received from 220participants. Out of the 220 women who participated in this cross-sectional study, 45 of them had BDD (prevalence rate of 20.5%), which is a significant percentage. The results of the study indicate that BDD is more prevalent among participants in the age group of 20â€“35 years. The study also revealed that a positive correlation exists between BDD and females seeking cosmetic procedures. we found thatOne-fifth of the participants were diagnosed to be suffering from BDD. Higher rates of BDD were observed among women who underwent cosmetic procedures. Therefore, we recommend physicians to conduct a BDD screening for patients seeking cosmetic procedures before treatment.
CONSUMPTION COAGULOPATHY FOLLOWING SINGLE FETAL DEMISE IN SECOND TRIMESTER DCDA TWIN PREGNANCY-A RARE CASE REPORT
Authors: a Poojitha , A. Sudharani , K. Sreelatha
Published: December 2022

Multifetal pregnancies are estimated to represent 3.2% of all pregnancies (80% are dichorionic and 20% monochorionic) and are associated with a higher risk of perinatal morbidity and mortality relative to single pregnancies. Single fetal loss of a twin pregnancy during the first trimester is not an uncommonevent and seems not to impair the further development of the surviving one. In gestational losses where the fetus is retained intrauterine for at least 10 weeks, there is the possibility of finding fetus papyraceus at the time of delivery. This is a rare event that results from incomplete reabsorption of the dead fetus, which is then compressed between the membranes and the uterine wall. In contrast, the death of a twin in the late second or third trimester of pregnancy isa rare obstetric complication associated with increased maternal and fetal morbidity andmortality.Herein, the authors report a successful management of maternal DIC following single fetal death in the second trimester of a dichorionicdiamniotictwin pregnancy.
THE EFFECTIVENESS LEARNING MODEL OF THE PROBLEM STATE, EXPLORE,DO, ANALYSIS AND ASSESSMENT (PEDAAS) TO TRAIN CRITICAL THINKING SKILLS AND LEARNING OUTCOMES FOR JUNIOR HIGH SCHOOL STUDENTS IN SCIENCE LEARNING
Authors:   Department of Science Masters, University of Jember, Jember, Indonesia 68121., Ria Agustin Dewi , a Indrawati ,   Department of Science Masters, University of Jember, Jember, Indonesia 68121., b Sudarti ,   Department of Science Masters, University of Jember, Jember, Indonesia 68121.
Published: December 2022

This study aims to describe the effectiveness of the PEDAAs learning model to train critical thinking skills and improve junior high school students learning outcomes in science learning. This learning model is structured to train students critical thinking skills which are still low. The science subject matter taken is waves, light, and sound because the scores obtained are less than the minimum completeness criteria. The research method is Quasi Experiment with Pretest-Posttest without control class. Data analysis was performed using mixed methods, which is the result of qualitative and quantitative data. The sample used was 29 students from class VIII.1 SMPN 1 Siliragung Banyuwangi. These results can be seen from the scores obtained by students, namely N-Gain. For critical thinking skills, the average N-Gain value is 0.75 in the high category. And for student learning outcomes, the N-Gain value is 0.72 in the high category. This shows that the PEDAAs learning model is effective in training critical thinking skills and improving student learning outcomes.
QUALITATIVE DIAGNOSTIC OF CROCUS SATIVUS L. FROM DIFFERENT ENDEMIC ORIGINS OF TALIOUINE REGION IN THE SOUTH OF MOROCCO: HYGROSCOPIC BEHAVIOR AND MAIN SECONDARY METABOLITES ANALYSIS
Authors:   Research team: Materials, Mechanical and Civil Engineering, ENSA, Ibn Zohr University, BP 1136 Agadir, Morocco., Oubella Khadija , Mouhanni Hind ,   Research team: Materials, Mechanical and Civil Engineering, ENSA, Ibn Zohr University, BP 1136 Agadir, Morocco., Bendou Abdelaziz ,   Research team: Materials, Mechanical and Civil Engineering, ENSA, Ibn Zohr University, BP 1136 Agadir, Morocco.
Published: December 2022

This study examined the water activity and equilibrium moisture content of saffron stigmas from different aeras of Taliouine region, south of Morocco with a diversity of altitudes and climates. The static gravimetric method was used to explain the hygroscopic behavior of saffron at three different temperatures (30, 40, and 50 Â°C). The quality of these saffron samples was evaluated by determining the concentration of their main compounds: safranal, crocin and picrocrocin using the ISO 3632-2 method by UV-vis. The water activity for conservation of Crocus sativus L. was range between 0.32 and 0.34 under the experimental conditions. The impact of the three irrigation systems (drip, gravity and porous) on the water activity has been studied. All the six endemic origins identified by altitudes (2100 m, 1700 m, 1600 m, 1500 m, 1200 m and 1000 m) used in this diagnosis were classified according to ISO 3632-1 in two classes: categories I for saffron from altitudes 1700, 1600 and 1200 m and categories II for saffron from altitudes 2100, 1500 and 1000 m. The samples from altitude 1700 m recorded high quality of secondary metabolites represented by concentrations of crocin (291.68 ) and picrocrocin (120.11 ).
SIGNIFICANCE OF EMOTIONAL INTELLIGENCE IN LEADERSHIP ROLES FOR FINANCIAL PLANNERS
Authors: Pushkarna Megha
Published: December 2022

Emotional Intelligence is a necessity in our present times. It gives us the knowledge and integrity to manage ourselves and see through our goal attainment. Emotional Intelligence also serves a key role in our functionality as an individual both in personal life and in a professional arena. At work our social milieu as well asour team interaction makes a significant impact on our work performance. This is true for financial planners whose nature of work involves meeting financial targets and managing teams who may at times show a dip in performance. This paperis a correlational study that evaluates potential relationships of emotional intelligence (five components like self- awareness, managing others, managing emotions, empathy, and social skills) in senior managers. The outcome of this study reveals the need for the financial planning industry to acknowledge emotional intelligence as one of the key roles in self-awareness and social skills. The essence of this study is in realizing that the financial services industry intentionally attracts individuals who display essential sales and marketing characteristics and how EI complemented the sought-after behaviors needed in the industry. This study focuses on an innate ability that would alter existing characteristics making individuals capable of managing stress, a factor that influences the success and profit of a company (Shah & Maheshwari, 2013).
Relationship between financial stress and financial well-being of micro and small business owners: Evidence from India
Authors: Ravikumar Thangaraj , Sriram Mali , Kannan Nagalingam , Elias Issac , Seshadri Vinita
Published: December 2022

Micro and small businesses financially suffered due to COVID-19 in India. This financial suffering created financial stress among them and deteriorated their financial well-being. However, micro and small business owners exhibit financial resilience by bouncing back to regular business activities through their hope, optimism, and self-efficacy, which are the components of positive psychological capital. This study analyzes the relationship between financial stress and financial well-being of micro and small firm owners keeping financial resilience as a mediator and positive psychological capital as a moderator in the mediation. This descriptive analysis employed a survey method to collect primary data using the interview method. The interview method was used as most micro and small business owners are comfortable with interaction rather than filling out the questionnaires due to the language barrier. The sample size is 384 respondents, as per Krejcie and Morgan’s formula. The mean scores indicate a moderate degree of financial stress (2.354), financial resilience (2.623), and financial well-being (2.637). The level of financial stress differs based on the respondents’ gender. Financial stress is more among female business owners (2.504) than their male counterparts (2.265).Further, business owners who earn more have a higher level of financial resilience (2.985), psychological capital (2.951), and financial well-being (2.711). Financial stress significantly impacts financial well-being (28.4%). Financial resilience has a partial mediation effect (65%) on financial stress and financial well-being. Finally, psychological capital moderates indirect relationships among financial stress, financial resilience, and financial well-being.
Future trends in atmospheric circulation patterns over Africa south of the equator
Authors: Ibebuchi Chibuike Chiedozie
Published: December 2022

The impact of climate change on the frequency of occurrence of atmospheric circulation patterns can have a wide range of consequences ranging from weather extremes to the modification of pollutant transport. This study uses 11 CMIP6 global climate models (GCMs) to investigate the impact of future climate change on the frequency of occurrence of atmospheric circulation patterns, in Africa south of the equator. Here it is shown from the historical analysis that there are statistically significant trends in the frequency of occurrence of some of the classified circulation types (CTs) in the study region. Further, under the SSP5-8.5 and SSP2-4.5 emission scenarios, the historical CTs were reproduced, suggesting that future climate change will not constrain the existence of the CTs. However, for future emission scenarios, the ensemble of the GCMs projects notable changes in the spatial structure of the CTs and statistically significant trends in the frequency of occurrence of most of the CTs, towards the end of the 21st century. The intensity of the projected changes in the spatial structure and linear trends in the frequency of occurrence of the CTs are relatively stronger under the higher emission scenario. As regards changes in synoptic circulations in the study region, the ensemble of the GCMs project, (i) a positive trend in the frequency of occurrence of austral summer dominant CTs associated with atmospheric blocking of the Southern Hemisphere mid-latitude cyclones, adjacent to South Africa; (ii) alternating frequent periods of enhanced (suppressed) anticyclonic circulation at the western branch of the Mascarene high possibly due to a more positive phase of the Southern Annular Mode (warmer southwest Indian Ocean); (iii) possible weakening of the Angola low. The aforementioned changes can be expected to have direct impacts on the regional climates in the study region.
Süpervizyonun Genç Neferleri: Türkiye’ de Süpervizyon Uygulamaları
Authors: KİYE Semra
Published: December 2022

Süpervizyon, daha deneyimli meslek elemanının daha deneyimsiz olanın gelişimine ilişkin yürüttüğü sistematik bir müdahaledir. Bu araştırmanın amacı Türkiye’ de süpervizyon verme sürecinde uzman desteği sağlayan araştırma görevlilerinin bu konudaki algı, görüş ve deneyimlerini inceleyerek var olan durumu betimlemektir. Araştırma nitel araştırma yöntemlerinden fenomenoloji çalışması olarak yürütülmüştür. Çalışma grubu Türkiye’nin Doğu Anadolu Bölgesi, İç Anadolu Bölgesi ve Ege Bölgesi’ nde yer alan toplam dokuz üniversitesinde görev yapan 12 araştırma görevlisinden (6 kadın, 6 erkek) oluşmaktadır. Verilerin toplanması katılımcılarla internet ortamında yapılan görüşmelerle sağlanmıştır. Yapılan görüşmelerde Demografik Bilgi Formu ile Yarı Yapılandırılmış Görüşme Formu kullanılmıştır. Verilerin analizinde betimsel analiz tekniği kullanılmıştır. Bulgulara göre üç ana temaya ulaşılmıştır. Bu ana temalar süpervizyon almaya ilişkin görüşler, süpervizyon vermeye ilişkin görüşler ve süpervizör olmaya ilişkin görüşlerdir. Sonuç olarak katılımcıların çoğunun eğitim süreçlerinde süpervizyon aldığı ancak grubun yarısının süpervizör olmaya ilişkin hiçbir eğitiminin olmadığı tespit edilmiştir. Ayrıca katılımcıların hemen hepsinin süpervizyon uygulamalarına ilişkin standartların oluşturulması gerektiğini dile getirdiği belirlenmiştir.