bluuebunny/crossref_metadata_2025 huggingface dataset:
G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells
Authors: Liao Chiao-Chun , Long Yuqing , Tsai Ming-Lin , Lin Chun-Yu , Hsu Kai-Wen , Lee Chia-Hwa
Published: December 2024

Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, limiting their applicability in preclinical drug investigations. In this study, we developed a non-invasive autophagy detection system (NIADS-autophagy, also called G-cleave LC3B biosensor) by integrating a split-luciferase-based biosensor with an LC3B cleavage sequence, which swiftly identified classic autophagic triggers, such as Earle's Balanced Salt Solution and serum deprivation, through protease-mediated degradation pathways. The specificity of G-cleave LC3B biosensor was confirmed via CRISPR gene editing of pivotal autophagy regulator ATG4B, yielding diminished luciferase activity in MDA-MB-231 breast cancer cells. Notably, the G-cleave LC3B biosensor exhibited strong concordance with established autophagy metrics, encompassing LC3B lipidation, SQSTM1 degradation, and puncta accumulation analysis. To underscore the usage potential of the G-cleave LC3B biosensor, we discovered that resveratrol acts as a synergistic enhancer by significantly potentiating apoptosis in MDA-MB-231 cells when combined with doxorubicin treatment. Overall, the luminescence-based G-cleave LC3B biosensor presents a rapid and dependable avenue for determining autophagy activity, thereby facilitating high-throughput assessment of promising autophagy-associated anti-cancer therapies across diverse malignancies.
Identification of serum biomarkers for cystic echinococcosis in sheep through untargeted metabolomic analysis using LC–MS/MS technology
Authors: Wu Xiao-Xia , Ban Wan-Li , Wu Li-Jiang , Qi Wen-Jing , Borhani Mehdi , He Xiao-Ying , Liu Xiao-Lei , Liu Ming-Yuan , Ding Jing
Published: December 2024

Background

Echinococcosis is a zoonotic disease caused by an Echinococcus tapeworm infection. While diagnostic methods for humans often rely on ultrasound imaging and immunodiagnostic techniques, diagnosis in intermediate hosts typically has no widely used diagnostic markers, hampering disease control efforts.

Methods

The differences in serum metabolites of sheep infected with Echinococcus granulosus and a control group were analyzed using ultrahigh-performance liquid chromatography (UHPLC) separation with tandem mass spectrometry (MS/MS) detection. This provided a basis for the early diagnosis and pathogenetic study of cystic echinococcosis (CE) in intermediate hosts at the metabolomics level. Orthogonal projections to latent structures–discriminant analysis (OPLS-DA) were used to analyze different metabolites in the serum of the two groups. The differentially abundant metabolites were entered into the MetaboAnalyst 5.0 online analysis website for processing, and the top-15-ranked metabolic pathways were set to produce bubble plots and differential abundance score plots, with a significant difference of P < 0.05 and a false discovery rate (FDR) < 0.1 as the screening conditions.

Results

Data analyses of serum samples from both groups identified a total of 1905 significantly different metabolites, where 841 metabolites were upregulated and 1064 metabolites were downregulated. Twelve metabolites were significantly upregulated and 21 metabolites were significantly downregulated in the experimental group. Then, the 1,7-dihydroxyxanthone, 2-methylbutyrylglycine, 3,3-dimethylglutaric acid, 5,12-dihydroxy-6,8,10,14,17-eicosapentaenoic acid, 9-hydroperoxy-10E,12Z,15Z-octadecatrienoic acid, and trimethylamine N-oxide 6 metabolites were selected as diagnostically valuable candidate biomarkers (area under the curve [AUC] > 0.7). These differential metabolites are involved in various metabolic pathways, including amino acid metabolites (arginine, l-isoleucine, l-valine) and fatty acid metabolism (fenugreek, arachidonic acid, linolenic acid). Compared with the control group, sheep in the CE group had increased serum levels of fenugreek acid, while all other metabolites such as glycine showed significantly reduced serum levels (P < 0.01).

Conclusions

Through non-targeted metabolomic analysis of the serum of CE-infected sheep, differential metabolites closely related to amino acid metabolism and the fatty acid metabolism pathway were identified. These differentially abundant metabolites can serve as biomarkers for diagnosing CE infection in intermediate sheep hosts.

Graphical abstract
Blood-based biomarkers and plasma Aβ assays in the differential diagnosis of Alzheimer’s disease and behavioral-variant frontotemporal dementia
Authors: Mohaupt Pablo , Kindermans Jana , Vialaret Jérôme , Anderl-Straub Sarah , Werner Leonie , Lehmann Sylvain , Hirtz Christophe , Otto Markus , Oeckl Patrick
Published: December 2024

Introduction

The differentiation between Alzheimer’s disease (AD) and behavioral-variant frontotemporal dementia (bvFTD) can be complicated in the initial phase by shared symptoms and pathophysiological traits. Nevertheless, advancements in understanding AD’s diverse pathobiology suggest the potential for establishing blood-based methods for differential diagnosis.

Methods

We devised a novel assay combining immunoprecipitation and mass spectrometry (IP-MS) to quantify Amyloid-beta (Aβ) peptides in plasma. We then assessed its performance against existing assays (Shimadzu and Simoa) and evaluated a range of other blood-based biomarkers, including GFAP, NfL, and pTau-181, for differentiating between AD and bvFTD.

Results

The novel IP-MS assay measuring the Aβ42/40 ratio demonstrated an AUC of 0.82 for differentiating AD from control subjects. While it did not significantly outperform the composite biomarker score from the Shimadzu assay (AUC = 0.79, P = 0.67), it significantly outperformed the Shimadzu Aβ42/40 ratio (AUC = 0.65, P = 0.037) and the Simoa Aβ42/40 assay (AUC = 0.57, P = 0.023). Aβ biomarkers provided limited utility in distinguishing AD from bvFTD. In contrast, pTau181 and GFAP exhibited strong discriminatory power for differentiating AD from bvFTD, with AUCs of 0.90 and 0.87, respectively. Combining pTau181 and GFAP enhanced diagnostic accuracy, achieving an AUC of 0.94.

Conclusion

We introduced a novel IP-MS assay that demonstrated comparable precision to the Shimadzu composite score in differentiating AD from non-neurodegenerative control groups. However, Aβ levels did not enhance the discrimination between AD and bvFTD. Furthermore, our findings support the utility of combining pTau181 and GFAP as a robust strategy for the blood-based differentiation of AD and bvFTD.
L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis
Authors: Amer Ahmed E. , Ghoneim Hamdy A. , Abdelaziz Rania R. , Shehatou George S.G. , Suddek Ghada M.
Published: December 2024

Background

UpToDate, no drugs have been approved to treat nonalcoholic steatohepatitis, the advanced stage of the most prevalent liver disease, non-alcoholic fatty liver disease. The present study was conducted to explore the potential influences of L-carnitine on the pathomechanisms of hepatic injury that mediate progression to non-alcoholic steatohepatitis in dexamethasone-toxified rats.

Methods

Male Wistar rats were allocated as follows: dexamethasone group, rats received dexamethasone (8 mg/kg/day, intraperitoneally) for 6 days; DEXA-LCAR300, DEXA-LCAR500, and DEXA-MET groups, rats administered L-carnitine (300 or 500 mg/kg/day, IP) or metformin (500 mg/kg/day, orally) one week prior to dexamethasone injection (8 mg/kg/day, IP) and other six days alongside dexamethasone administration. Two groups of age-matched normal rats received either the drug vehicle (the control group) or the higher dose of L-carnitine (the drug-control group). At the end of the experiment, sets of biochemical, histological, and immunohistochemical examinations were performed.

Results

L-carnitine (mainly at the dose of 500 mg/kg/day) markedly abolished dexamethasone-induced alterations in glucose tolerance, hepatic histological features, and serum parameters of hepatic function and lipid profile. Moreover, it significantly ameliorated dexamethasone-induced elevations of hepatic oxidative stress, SREBP-1 and p-MLKL protein levels, and nuclear FOXO1, LC3, P62, and caspase-3 immunohistochemical expression. Furthermore, it markedly diminished dexamethasone-induced suppression of hepatic Akt phosphorylation and Bcl2 immunohistochemical expression. The effects of L-carnitine (500 mg/kg/day) were comparable to those of metformin in most assessments and better than its corresponding lower dose.

Conclusion

These findings introduce L-carnitine as a potential protective drug that may mitigate the rate of disease progression in non-alcoholic fatty liver disease patients with early stages or those at the highest risks.
The role of endoscopic ultrasound in the diagnosis and characterization of focal liver lesions
Authors: Hashim Ahmed Morad , Gamal Gamal Eldin Mansour Mohamed , Abdellatef Abeer , Ahmed Hany Hagag
Published: December 2024

Background

Incidentally discovered focal liver lesions (FLLs) are a common reason for referral to hepatobiliary services. These lesions are frequently found in patients with colorectal cancer, cirrhosis, or incidentally during evaluations for abdominal pain or shock. Several established diagnostic tools such as magnetic resonance imaging (MRI), transabdominal ultrasound (US), and computed tomography (CT) are well-studied for assessing liver diseases. Endoscopic ultrasound (EUS), traditionally used for evaluating the mediastinum, biliary tract, esophagus, stomach, and pancreas, is increasingly complementing these traditional diagnostic methods in hepatology. The study aimed to delineate the endoscopic ultrasound elastography role in visualization and hepatic focal hepatic tissue differentiation of lesions in comparison to the routine radiological and laboratory methods.

Methods

A cross-sectional study was conducted, we enrolled 41 patients with hepatic focal lesions, abdominal ultrasonography, triphasic CT abdomen, and Endosonography examinations were performed on all participants.

Results

There was a highly significant difference between the studied groups as regards the Strain Ratio and Echogenicity (P0.01).

Conclusion

Ultrasound elastography and strain ratio are promising, non-invasive, nondependent on any contrast material techniques that could significantly enhance routine grey-scale sonographic examinations of the liver by better delineating the characteristics of hepatic focal lesions.
Dynamic Inconsistency in Risky Choice: Evidence from the Lab and Field
Authors: Heimer Rawley , Iliewa Zwetelina , Imas Alex , Weber Martin
Published: December 2024

We document a robust dynamic inconsistency in risky choice. Using a unique brokerage dataset and a series of experiments, we compare people's initial risk-taking plans to their subsequent decisions. Across settings, people accept risk as part of a loss-exit strategy—planning to continue taking risk after gains and stopping after losses. Actual behavior deviates from initial strategies by cutting gains early and chasing losses. More people accept risk when offered a commitment to their initial strategy. Our results help reconcile seemingly contradictory findings on risk-taking in static versus dynamic contexts. We explore implications for theory and welfare. (JEL D81, G13, G24, G41)
The Global Financial Resource Curse
Authors: Benigno Gianluca , Fornaro Luca , Wolf Martin
Published: December 2024

We provide a model connecting the global saving glut to productivity growth. The key feature is that the tradable sector is the engine of growth of the economy. Capital flows from developing countries to the United States boost demand for US nontradable goods, inducing a reallocation of US economic activity from the tradable sector to the nontradable one. In turn, lower profits in the tradable sector lead firms to cut back investment in innovation. Since innovation in the United States determines the evolution of the world technological frontier, the result is a drop in global productivity growth. (JEL E21, E22, E23, E44, F32, F43, O31)
Organized Voters: Elections and Public Funding of Nonprofits
Authors: Urvoy Camille
Published: December 2024

What makes politicians respond to civil society organizations' demands? I use new data on government transfers to French associations and exploit close elections to show that politicians grant more funds to ideologically close organizations when the local incumbent is a political ally and was elected by a small margin. The results are consistent with politicians and organizations exchanging financial support for electoral support. Organizations secure funding because of the votes they can deliver, not because of their campaign contributions; however, the fact that transfers appear to be conditioned on support may undermine their ability to help hold politicians accountable. (JEL D23, D72, H81, L31)
A Short Introduction to the History of the Kosciuszko Foundation and Its Programs
Authors: Szymańska Małgorzata
Published: December 2024

The text outlines the history of the Kosciuszko Foundation, paying special attention to the life of its founder, Szczepan Mierzwa, who came to the USA in 1910, at the age of 17. By 1925 he changed his name to Stephen Mizwa, became Assistant Professor of Economics at Drake University, and founded the Kosciuszko Foundation in New York City, which has been providing financial support to Polish scholars ever since. The text also gives an overview of all the programs that the Kosciuszko Foundation currently offers to Polish and American scholars and students.
“Let’s All Be Americans Now”
Authors: Parafianowicz Halina
Published: December 2024

The purpose of the article is to present a brief overview of the Americanization movement during the Great War, which strongly impacted the national policy on this matter and its evolution. National unity became particularly important and urgent in the context of war, especially after the U.S. entered the conflict. This involvement led to vigorous efforts to Americanize “all Americans,” as advocated by key players. Consequently, considerable attention from the government, various agencies, state and local offices, and several organizations focused on the foreign‑born and unassimilated immigrants, who were expected to demonstrate full loyalty, contribute to the U.S. workforce, and engage in patriotic service for the adopted country. The war’s urgent demands for workers, recruits, and loyal Americans accelerated the implementation of new Americanization avenues and sped up the assimilation policy for immigrants and the foreign‑born. The government, businesses, philanthropies, and various organizations propagated, conducted and implemented numerous programs addressed to these groups. The primary aim was to educate and prepare them for their duties to their new country, particularly aiding the war effort. Many immigrants assimilated through English language courses and thus were better prepared for American life. They contributed to the war effort by Hooverizing, working on the home front, buying Liberty Bonds and enlisting in the U.S. Army. Immigrant women were also a focus, with programs designed to prepare them for American values and community life through education and patriotic initiatives.
Cultural Chronicles – Uncovering the Legacy of Oppressive Black Architecture in Memphis and Other Cities
Authors: Osayamwen Esosa
Published: December 2024

Architectural structures and the spaces they create are not neutral; instead, they mirror the values and power dynamics of the societies in which they are constructed. This observation is particularly noticeable in the buildings African Americans inhabited throughout American history. Nevertheless, Black architecture has yet to be recognized as a culturally significant field within academia. To tackle this issue, this paper seeks to expand the architectural discourse by exploring what constitutes Black architecture. Specifically, we will investigate the histories of five houses that hold a particular place in African American historical architecture:• The barrack,• The slave cabin,• The shotgun house,• The housing projects,• The Black suburban homes.Our investigation will delve into the repercussions of each style, the societal goals in establishing each class, and the policies passed that instigated their creations. We will emphasize the connections between these styles and how each type has changed over time. This exploration will allow us to scrutinize Memphis’ architectural choices, placing them in the broader context of architectural trends at the national and regional levels. Exploring Black architecture’s evolution will also help us comprehend how architecture can contribute to racial inequality in our society. We aim to challenge the notion that architecture is only a symbol of beauty, shape, and form and instead recognize its potential to perpetuate subjugation, oppression, and control.
Transpozycja metryki antycznej w przekładach na język polski – próba klasyfikacji
Authors: Heszen Agnieszka
Published: December 2024

TRANSPOSITION OF ANCIENT METRICS IN POLISH TRANSLATIONS – AN ATTEMPT AT CLASSIFICATION
The article discusses the existing ways of translation – transposition of ancient metrics into Polish, along with a proposal for their classification. It addresses the issue of metrical equivalence in a language that does not have a quantity and it shows, how the principles of quantitative metrics can be replaced in translations of poetry. These issues are discussed by several selected examples from epic and lyric, and the types of transposition were defined and characterized.
ANALISIS MINERALOGI DAN GEOKIMIA ENDAPAN KROMIT DAERAH BULO-BULO KECAMATAN PUJANANTING KABUPATEN BARRU PROVINSI SULAWESI SELATAN
Authors: Harwan Harwan , Jafar Nurliah , Heriansyah Andi Fahdli , Aulia Rizky Nurul
Published: December 2024

Daerah di Sulawesi Selatan yang memiliki potensi endapan kromit yaitu daerah Barru dimana memiliki tiga daerah potensi yaitu daerah Bulo-Bulo, Daerah Bulo-Bulo dan daerah Batubesi. Pada penelitian ini peneliti melakukan penelitian di daerah Bulo-Bulo, Kecamatan Pujananting, Kabupaten Barru. Kompleks batuan ultrabasa di Sulawesi Selatan mempunyai rangkaian batuan ultrabasa yang mengandung kromit. Umumnya di daerah Sulawesi, endapan kromit ditemukan dalam bentuk lapisan stratiform dalam batuan iherzolit dan dunit. Distribusi lapisan endapan kromit terbentuk di beberapa tempat dengan bentuk lensa tipis. Analisis kimia mineral kromiun menunjukkan bahwa mineral kromium berasal dari batuan peridotit yang terbentuk dari back arc basin dan fore arc basin. Endapan Kromit pada daerah penelitian batuannya berasosiasi dengan batuan ultrabasa yang terserpentinkan. Cebakannya sangat berkaitan dengan proses pengentalan magma ultrabasa, sebab luas rapat massa jenisnya sehingga terkumpul dalam bentuk kumulus di dalam massa batuan ultrabasa tersebut. Pada penelitian ini analisis yang digunakan yaitu analisis mineragrafi untuk menentukan mineral pembawa bijih kromit, analisis XRD untuk menentukan mineral utama pembawa bijih kromit dan asosiasinya dan analisis XRF untuk menentukan komposisi kimia dari mineral bijih kromit. Mineral pembawa endapan kromit pada daerah penelitian yaitu mineral kromit (Cr2O3) dengan mineral asosiasi yaitu magnetit dan geotit. Cr2O3 hadir dengan persentase berkisar 41,09% - 42,59%. Tingginya persentase senyawa Cr2O3 sesuai dengan tingginya kehadiran mineral Kromit Oksida dari hasil analisis mineragrafi dan XRD untuk semua sampel. Senyawa Fe2O3 dengan persentase berkisar antara 11,41% - 12,98%. Senyawa SiO2 pada analisis sampel endapan kromit berkisar 0,23% - 0,37% menunjukkan tidak adanya aktifitas hidrothermal pada daerah penelitian.
EVALUASI AKURASI PADA ORTOFOTO DAN DIGITAL TERRAIN MODEL (DTM) BERDASARKAN PENAMBAHAN PARSIAL FOTO UDARA
Authors: Agustina Fransisca Dwi , Tjahjadi Martinus , Suaprana Lalu , Septamawati Suzanna
Published: December 2024

Teknologii dronei telahi menjadii salahi satui teknologii populeri yangi dimanfaatkani untuki pemetaani topografi.i Namun,i hasili akurasii ortofotoi dani Digitali Terraini Modeli (DTM)i perlui dii kajii akurasinya,i yangi seringkalii berpengaruhi padai hasili resolusii foto.i Dalami penelitiani ini,i dilakukani penambahani parsiali fotoi udarai yangi diambili darii beberapai bagiani wilayahi tertentui untuki melengkapii dani meningkatkani detaili sertai akurasii datai yangi telahi ada,i sepertii ortofotoi dani DTM.i Penambahani fotoi udarai tersebuti diharapkani dapati meningkatkani akurasii hasili pemetaan.i Dengani menerapkani penambahani fotoi udarai nantinyai dapati memengaruhii dani meningkatkani akurasii padai ortofotoi dani DTM.i Metodei evaluasii akurasii yaitui mencakupi perbandingani visuali dani analisisi akurasii posisii menggunakani datai pengukurani GPSi darii titiki kontrol.i Pengujiani akurasii dilakukani dengani menghitungi Rooti Meani Squarei Errori (RMSE)i untuki menilaii ketepatani posisii padai ortofotoi dani DTM.i Maka,i hasili ketelitiani horizontali dani vertikali sesuaii dengani standari ASPRSi sebelumi dani sesudahi adanyai penambahani parsiali fotoi udarai mendapatkani selisihi i 0.06i mi dani 0.05i mi RMSEr.i Hasili ketelitiani vertikali sebelumi dani sesudahi adanyai penambahani parsiali fotoi udarai mempunyaii selisihi 0,0465i mi dani 0,0461i mi RMSEz.i Berdasarkani hasili evaluasii akurasii padai ortofotoi dani DTMi dapati disimpulkani bahwai penambahani parsiali fotoi udarai dapati memengaruhii ataui meningkatkani akurasii ortofotoi dani DTM.
Revitalisasi Pendidikan Digital: Implementasi Desain Grafis berbasis Kecerdasan Buatan dalam Pengembangan Media Belajar untuk Guru di Pesisir Kabupaten Sumenep - Madura
Authors: Wulandari Sri Pingit , Ratih Iis Dewi , Wildani Zakiatul , Wibowo Wahyu , Retnaningsih Sri Mumpuni , Dinanti Lucia Ari , Ilmansyah Muhammad Noorridho , Putri Eka Deviana , El Haqq Byrlianty Tsabita , Wulandari Ratna Maulidah , Putri Nur Sinta Dewi
Published: December 2024

Berdasarkan gugus kepulauan, Kabupaten Sumenep memiliki 126 Pulau yang tersebar membentuk gugusan pulau-pulau baik berpenghuni (48 Pulau) maupun tidak berpenghuni (78 Pulau). RLS (Rata-rata Lama Sekolah) di Kabupaten Sumenep pada tahun 2023 tercatat sebesar 5,94 tahun. Ini berarti hingga tahun 2023, secara rata-rata penduduk Kabupaten Sumenep usia 25 tahun ke atas mengenyam pendidikan hingga kelas V SD atau hampir menamatkan sekolah di jenjang SD. Pendidikan merupakan salah satu sektor penting yang harus diperhatikan pemerintah untuk mempersiapkan masyarakat yang berkualitas demi pembangunan yang berkelanjutan. Faktor penyebab utama meningkatnya angka putus sekolah seperti faktor ekonomi, faktor perhatian orang tua, fasilitas pembelajaran, minat anak untuk sekolah, budaya, dan faktor lokasi sekolah. Dari faktor-faktor tersebut dilakukan pengabdian masyarakat berupa pemberian pelatihan kepada guru untuk meningkatkan keterampilan dalam mendidik dan mengajar dengan mengimplementasikan Teknologi Kecerdasan Buatan (AI) untuk pembuatan media belajar digital. Media belajar yang digunakan adalah Canva. Pelatihan berupa penjelasan mengenai fitur Canva dan cara pembuatan desainnya, kemudian guru diberikan tugas untuk mengukur pemahamannya. Berdasarkan analisis dari tugas yang telah diberikan dapat disimpulkan bahwa mayoritas guru memiliki pemahaman yang baik terhadap materi pelatihan Canva sehingga pelatihan ini berhasil meningkatkan pemahaman guru dalam membuat materi pembelajaran menggunakan Canva.
Evaluasi Kondisi Struktur Terkini dan Rekomendasi Perkuatan pada Gedung Perkantoran di Surabaya
Authors: Yudoprasetyo Kohar , Tajunnisa Yuyun , Affandhie R. Buyung Anugraha , Suwandi Suwandi
Published: December 2024

Kegiatan pengabdian masyarakat ini bertujuan untuk mengevaluasi kondisi struktur terkini pada gedung perkantoran di Surabaya, yang dibangun oleh Dinas Perumahan Rakyat, Pemukiman, dan Cipta Karya, serta memberikan rekomendasi perkuatan kepada mitra terkait. Inspeksi visual pada struktur gedung mengidentifikasi retakan signifikan pada balok, terutama akibat bentangan kolom yang terlalu panjang, sehingga menimbulkan kerusakan lentur. Pengujian material, yang meliputi Schmidt Hammer, Ultrasonic Pulse Velocity (UPV), dan uji tekan inti beton, menunjukkan bahwa kuat tekan rata-rata beton adalah 23,71 MPa, di bawah standar mutu yang direncanakan sebesar 25 MPa. Sementara itu, hasil uji tarik baja tulangan menunjukkan nilai kuat tarik rata-rata sebesar 396 MPa. Analisa struktur menggunakan perangkat lunak SAP2000 mengungkapkan bahwa beberapa balok, terutama tipe B1, B3, B1', dan B3', mengalami overstress, dengan momen ultimate yang melebihi kapasitas struktur saat ini. Berdasarkan hasil analisis, direkomendasikan perkuatan struktur berupa portal tambahan yang terdiri dari balok baja WF 300x150 dan kolom baja WF 350x175 untuk meningkatkan kapasitas dan stabilitas bangunan. Perkuatan ini diharapkan mampu meningkatkan keamanan struktural gedung sehingga layak digunakan oleh mitra sesuai standar keselamatan yang berlaku.
Edukasi DAGUSIBU (DApatkan, GUnakan, SImpan, dan BUang) Obat sebagai Media Peningkatan Kesadaran Mahasiswa Kesehatan Universitas Muhammadiyah Surabaya
Authors: Wiputri Oktaviany Irma , Afifah Widiyanti , Az Zahra Aisyah Nabilla , Syamsiyah Dwi Fitri Nur , Nurjannah Elok Siti , Firdausi Nur Haliza
Published: December 2024

Penggunaan produk kesehatan seperti obat-obatan mengalami peningkatan pada masyarakat. Hal ini juga sejalan dengan meningkatnya angka penyalahgunaan obat dan munculnya penumpukan limbah obat. Oleh karena itu, perlu dilakukan pengelolaan obat secara komprehensif untuk menghindari kesalahan penggunaan obat dan risiko berbahaya melalui program DAGUSIBU. DAGUSIBU adalah singkatan dari "DApatkan, GUnakan, SImpan, dan Buang" yang ditujukan untuk meningkatkan pengetahuan masyarakat dalam pengelolaan obat yang baik dan benar. Mitra kegiatan pengabdian ini yaitu mahasiswa kesehatan di lingkup Universitas Muhammadiyah Surabaya yang mana mahasiswa berperan sebagai edukator kesehatan sehingga penting untuk menanamkan tanggung jawab dan kepedulian keamanan pengelolaan obat sejak dini. Kegiatan pengabdian kepada masyarakat ini dilakukan untuk meningkatkan kesadaran dan pengetahuan mahasiswa kesehatan tentang pengelolaan obat. Kegiatan pengabdian kepada masyarakat melibatkan mahasiswa kesehatan yang diselenggarakan di Universitas Muhammadiyah Surabaya dengan diawali pre-test, penyuluhan, post-test, evaluasi dan tindak lanjut. Responden yang terlibat dalam kegiatan ini adalah 74 mahasiswa. Hasil pre-test dan post-test menunjukkan peningkatan pengetahuan (50,2% menjadi 50,55%) dan sikap (50% menjadi 50,68%) responden terhadap pengelolaan obat-obatan. Penyuluhan program DAGUSIBU memberikan dampak positif terhadap pemahaman responden tentang obat-obatan dan efektivitasnya.
Sistem Pengering Batik Hybrid Berbasis Solar Dryer dan Drum Pemanas Menggunakan Kontrol Proporsional-Integral sebagai Solusi Peningkatan Produktivitas Batik Griya Amirah
Authors: Zukhruf Mochamad Helmi , Halim Christian Vieri , Rachmandika Firdha Chaylia Ayu , Tjandra Nabiilah Aziizah , Adani Naufal Shalhan , Nasution Aulia Muhammad Taufiq
Published: December 2024

Griya Amirah merupakan gerai batik dengan lokasi Jalan Kedinding Tengah I No.19-i, Kota Surabaya, Jawa Timur. UMKM ini menjual berbagai macam jenis batik dengan omzet Rp18.065.000 per bulan. UMKM ini memiliki permasalahan pada pengeringan batik. Hal ini dikarenakan cuaca yang tidak menentu sehingga pengeringan dilakukan pada malam hari. Dari adanya hal tersebut, maka dilakukan penerapan IPTEK berupa sistem pengering batik hybrid yang diberi nama Basurbid (Batik Surya Hybrid). Metode pelaksanaan dimulai dari pembuatan sistem pengering hingga monitoring dan evaluasi keberhasilan program. Hasil Basurbid yaitu terdapat peningkatan produksi batik mitra saat cuaca panas menjadi 20 kain dengan waktu 75 menit dan saat cuaca tidak panas menjadi 18 kain dengan waktu 60 menit. Hal ini berkorelasi dengan peningkatan jumlah produksi dan omzet dibandingkan sebelum implementasi berturut – turut yaitu 36% dan 67%.
Upaya Peningkatan Omzet Melalui Pemasaran Digital Berbasis Website dan Media Sosial pada Industri Rumah Tangga (IRT) Minyak Kelapa Kediri
Authors: Irawan Mohammad Isa , Mukhlash Imam , Rukmi Alvida Mustika , Hendy Hendy , Iqbal Mohammad , Probojati Rasyadan Taufiq , Hidayat Nurul , Rukmini Meme
Published: December 2024

Industri rumah tangga minyak kelapa “d’Hayfa Sukses Berkah” Kediri berdiri sejak tahun 2017. Usaha ini terletak di Jl. Kaliombo Perum Bumi Asri E-10 Kediri. Kualitas dari produk minyak kelapa Abila yang merupakan produk utama dari industri ini tidak kalah dibandingkan dengan produk sejenis yang ada di pasaran. Industri rumah tangga ini mampu menghasilkan beberapa produk turunan dari minyak kelapa, seperti sabun herbal dengan kandungan minyak kelapa dan kombinasi ekstrak tumbuhan berkhasiat, serum rambut, obat kutu, hand sanitizer, hand soap, cairan pencuci piring, serta pengharum ruangan. Dari hasil observasi dirasakan kurangnya pengetahuan masyarakat mengenai produk-produk yang dihasilkan serta kurangnya pengetahuan mengenai khasiat dan kegunaan dari produk mitra. Tujuan utama dari kegiatan abmas ini adalah untuk mengupayakan perluasan pangsa pasar melalui pemasaran digital sehingga produk minyak kelapa ini bisa dikenal luas dan meningkatkan pesanan. Sebuah website abilaindonesia.com dirancang tim abmas untuk mitra serta pengaturan unggahan media sosial yang berisi konten iklan maupun pengetahuan produk abila. Pembuatan website dan konten media sosial telah signifikan meningkatkan visibilitas online dari produk “d’Hayfa Sukses Berkah”. Penyediaan konten media sosial yang konsisten telah membantu membangun brand awareness dan keterlibatan pelanggan. Kegiatan ini mendukung pertumbuhan ekonomi berkelanjutan dan menciptakan pekerjaan yang layak (SDG 8), serta mendorong pola konsumsi dan produksi berkelanjutan (SDG 12).
Sistem Berkelanjutan Desalinasi Air Laut dan Produksi Garam Modern dengan Tenaga Surya di Eduwisata Mutiara Saghara
Authors: Putranto Teguh , Triastuti Warlinda Eka , Misbah Mohammad Nurul , Yulianto Totok , Yulianto Ardi Nugroho , Pribadi Sri Rejeki Wahyu , Suprapto Suprapto , Ningrum Eva Oktavia , Arief Irfan Syarief , Ariesta Rizky Chandra
Published: December 2024

BUMDes Mutiara Saghara mengembangkan usaha baru berupa Eduwisata Garam, yaitu wisata edukasi yang memperkenalkan proses pengolahan garam rakyat secara tradisional serta inovasi modernnya. Meskipun sektor garam berpotensi meningkatkan perekonomian warga Desa Bunder, saat ini kontribusinya masih belum optimal. Akibat dari minimnya kontribusi ini, produksi garam oleh petani tidak memberikan keuntungan ekonomis yang signifikan. Untuk mengatasi permasalahan tersebut, program pengabdian kepada masyarakat ini bertujuan mengintegrasikan sistem desalinasi air laut yang menghasilkan garam dan air hasil evaporasi. Pengabdian dilakukan secara bertahap mulai dari mendesain alat, mengadakan bahan baku, membuat alat, melakukan uji alat dan menyerahkan alat kepada mitra. Dalam proses utamanya, air hasil evaporasi yang memanfaatkan panas matahari akan dialirkan melalui pipa saluran ke bak penampung dan kemudian diproses dengan teknologi reverse osmosis (RO) untuk menghasilkan air bersih. Inovasi ini diharapkan dapat meningkatkan kualitas garam dan memberikan manfaat lain yaitu dapat menghasilkan air bersih. Sistem RO dirancang dapat menghasilkan air bersih 1000 gpd.
Eduwisata Berbasis Digital Mendukung Program Desa Cerdas Lingkungan dan Peningkatan Potensi Keanekaragaman Tumbuhan Lokal Masyarakat Alas Karetan, Kediri, Jawa Timur
Authors: Trisnawati Indah , Muryono Mukhammad , Desmawati Iska , Saptarini Dian , Muzaki Farid Kamal , Aunurohim Aunurohim
Published: December 2024

Wisata alam Alas Karetan Desa Tempurejo seluas 5 Ha yang terletak di dalam kawasan lindung Sumber Pawon dengan luas 12,4516 Ha, mengalami ancaman dengan semakin meningkatnya kunjungan wisatawan dan konversi lahan. Kelompok masyarakat maupun aktivis lingkungan setempat mengharapkan adanya pengelolaan dan pengembangan wisata alam yang berbasis lingkungan dan berkelanjutan. Adanya permasalahan serta urgensi ancaman keberlanjutan di kawasan lindung Sumber Pawon mendasari dilaksanakannya kegiatan pengabdian masyarakat ini. Tahap awal adalah gambaran umum tumbuhan serta penentuan titik koordinat sebaran tumbuhan sebagai dasar pembuatan peta lokasi wisata, sebaran spasial tumbuhan lokasi dan intepretasi sebarannya. Pada tahap selanjutnya, media pembelajaran berupa e-booklet dikemas menarik dan mudah dipahami masyarakat. Potensi lokal kawasan Alas Karetan termasuk sumber mata air, keanekaragaman tumbuhan hutan tropis, tumbuhan langka dan berbagai macam satwa, perlu diketahui oleh masyarakat Alas Karetan. Dengan demikian tujuan program Desa Cerdas dalam kegiatan ini dapat tercapai yaitu pengembangan dan implementasi program maupun teknologi berupa media pembelajaran digital yang dapat meningkatkan potensi lokal daerah. Dalam pengaplikasian media pembelajaran peta dan e-booklet secara umum diperlukan pertimbangan yang matang, terkait kesiapan dalam pemantauan dan pengawasan lokasi sebaran tumbuhan lokal, terutama tumbuhan yang berpotensi sebagai tumbuhan ornamental. Dalam kegiatan abmas ini akan terus dilakukan komunikasi dan koordinasi secara berkelanjutan dengan pengelola wisata dan kepala desa, agar edukasi lingkungan bagi masyarakat ini dapat tercapai secara optimal.
Pemberdayaan Ekonomi Masyarakat Melalui Pengembangan Potensi Lokal Susu Sapi di Desa Kemiri Kabupaten Pasuruan
Authors: Nugraha Dewi Amira Eka , Yuliati Nuriah , Nurhadi Eko , Atasa Dita
Published: December 2024

Desa Kemiri, Pasuruan, memiliki potensi besar dalam sektor peternakan sapi perah, namun sebagian besar produksi susu sapi di desa ini masih dipasarkan dalam bentuk mentah sehingga nilai tambahnya belum optimal. Dengan latar belakang tersebut, program pemberdayaan ekonomi masyarakat ini difokuskan pada pengembangan produk bernilai tambah, yaitu mochi berbasis susu sapi perah. Tujuan dari program ini adalah untuk meningkatkan kesejahteraan masyarakat desa melalui pelatihan pengolahan susu menjadi produk mochi serta pembekalan strategi pemasaran dan branding agar produk dapat bersaing di pasar yang kompetitif. Pelatihan ini mencakup teknik pemilihan bahan baku berkualitas, proses pengolahan yang tepat, serta cara mengemas dan melakukan branding agar produk menjadi lebih menarik. Hasil kegiatan menunjukkan peningkatan keterampilan peserta dalam pengolahan produk lokal berbahan dasar susu sapi, sekaligus membuka peluang pasar yang lebih luas untuk produk mochi. Diharapkan implementasi program ini dapat menjadi model pemberdayaan ekonomi yang berkelanjutan dan direplikasi di desa-desa lain dengan potensi serupa.
LSCM Podcast Series: Pengenalan Cabang Ilmu Teknik Industri kepada Masyarakat melalui Saluran Digital
Authors: Putera Rizki Revianto , Suparno Suparno , Pujawan I Nyoman , Rusdiansyah Ahmad , Vanany Iwan , Arvitrida Niniet Indah , Hartanto Dody , Savitri Niken Anggraini
Published: December 2024

Podcast LSCM bertujuan untuk meningkatkan pemahaman masyarakat, khususnya mahasiswa dan profesional, mengenai pentingnya logistik dan manajemen rantai pasok. Bidang ini memiliki peran yang sangat vital dalam mendukung ekonomi dan kehidupan sehari-hari, tetapi kesadaran publik terhadap dampaknya masih tergolong rendah. Dalam era digital, tingginya penggunaan media sosial di Indonesia menciptakan peluang untuk menyebarkan informasi dengan cara yang lebih luas dan mudah diakses. Pada podcast ini menghadirkan berbagai topik seperti pemilihan pemasok, rantai pasok global, dan logistik halal, yang dibahas oleh dosen ahli dari Laboratorium Logistic and Supply Chain Management ITS. Setiap episode berdurasi 15-20 menit, dirancang agar mudah dipahami dan menarik bagi audiens yang lebih muda, dengan format yang fleksibel dan informatif. Podcast ini akan tersedia di berbagai platform digital seperti YouTube dan Spotify, sehingga audiens dapat mengakses konten edukatif ini kapanpun dan dimanapun. Kegiatan ini diharapkan dapat meningkatkan kesadaran akan pentingnya logistik dan rantai pasok, serta memotivasi generasi muda untuk lebih memahami konsep dasar dan tren terbaru dalam bidang ini. Dengan cara ini, podcast LSCM diharapkan berkontribusi dalam membangun sistem rantai pasok yang lebih efisien dan berkelanjutan di masa depan.
Preserving oral health
Authors: Silver Phil
Published: December 2024

Phil Silver discusses the link between connective tissue disease and oral health.
Protecting the environment
Authors: Waters Rebecca
Published: December 2024

Rebecca Waters reminds us of the need for sustainable waste protocol.
Viva las vegan
Authors: Turner Andrew
Published: December 2024

Andrew Turner outlines the effects of veganism on oral health.
The daily grind
Authors: Budgen Krista
Published: December 2024

Krista Budgen offers a dental nurse's guide to sleep teeth grinding.
Go with your gut
Authors: Symons Anne
Published: December 2024

Anne Symons emphasises the need for good oral hygiene for IBD patients.
The essence of good oral health
Authors: Smith Rebecca
Published: December 2024

Rebecca Smith relays the importance of oral hygiene for an ageing population.
Expanding your knowledge
Authors: Fitzsimons Rebecca
Published: December 2024

Rebecca Fitzsimons reflects on her dental nursing career.
Looking ahead
Authors: Saghir Affan , Cousins Jade
Published: December 2024

Affan Saghir and Jade Cousins explore the role of the dental nurse in cosmetic dentistry.
Beating the new year blues
Authors: Fisher Rochelle , Chadbourne Emily
Published: December 2024

Rochelle Fisher and Emily Chadbourne discuss how best to get through those winter days.
Effect of Dental Service Quality on the Intention to Revisit Hospital and Satisfaction with Treatment
Authors: Jung Ui-Jung
Published: December 2024

Objective: This study was aimed to confirm the relevance of treatment satisfaction, dental hygienists’expertise and communication, dental treatment procedures, dental hospital environment and intention to revisit, and identify factors that affect the intention to revisit and satisfaction with dental treatment. Methods: Data were collected from 299 dental patients from May 8-25, 2023. Data were analyzed using IBM SPSS 23.0. The collected data were analyzed using t-test, one-way ANOVA, Pearson’s correlation, and multiple regression. Results: All the variables showed positive correlations. Particularly, dental hygienists’ expertise and communication and treatment satisfaction, and dental hygienists’ communication, treatment satisfaction, and expertise had a high correlation. Dental hygienists’ communication, dental treatment procedures, and the dental environment had a significant impact on the intention to revisit. The variables that significantly affected treatment satisfaction were communication among dental hygienists and the dental environment. Conclusions: Communication among dental hygienists is an important factor in treatment satisfaction and intention to revisit. Efforts are required to improve the quality of dental services and patient satisfaction.
Pulp Calcification and External Reabsortion Resulting from Dental Trauma in Childhood, Associated with the Applicability of Guided Endodontic Treatment – Endoguide: Case Report
Authors: Pereira Meireles Milena Rodrigues , Olívia Leão Polliane , Vieira Frujeri Maria De Lourdes , Oliveira Moraes Alyne Michelle , Oliveira Silva Poliana Amanda
Published: December 2024

Introduction: Pulp canal calcification is characterized by the deposition of calcified tissue along the canal walls. As a result, the root canal can become completely obliterated, making endodontic treatment and its chemical- mechanical preparation difficult and contributing to accidents and complications. The objective of this case report is to understand that digital dentistry has added value in several dental situations. Endoguide provides safety, precision, efficiency, minimizes operative time, and reduces the chances of root canal deviation and damage to surrounding tissues.
Methodology: The literature review was carried out through a bibliographic survey on guided endodontic treatment in obliterated canals. The clinical case reported here was treated at the dentistry clinic of the Euro-American University Center (UNIEURO).
Case report: A 23-year-old female patient with a history of trauma in the anterior region of the maxilla at least 10 years ago reported that there was no intervention at the time of the incident and detailed how the trauma occurred. The patient presented to the UNIEURO dental clinic complaining of darkening of the crown of tooth 21. Radiographically, significant external resorption was observed and the clinical examination showed marked vestibularization. When performing sensitivity tests on tooth 21, negative responses were obtained. The lower teeth were also the focus of observation for analysis of possible impairment during the trauma that occurred. It was observed that all were vital, except for tooth 21, thus confirming the diagnostic hypothesis of Pulp Calcification. The patient was referred to the radiology clinic with a request for an imaging exam: Computed Tomography on a Prexion device; known for allowing a more detailed view of the root canal system and the periapical region. Subsequently, intraoral scanning was performed at the Voxells clinic, where the Stereo lithography (STL) file was acquired and combined with images in the DICOM (Digital Imaging and Communications in Medicine) file. Subsequently, Trion was responsible for developing the 3D model and printing it to guide the endodontic access surgery in the appropriate position and angle.
Conclusion: The guided endodontic technique is safe, effective and faster. It increases predictability, minimizes the risk of deviations and perforations, and promotes greater comfort for the patient and dentist. It is important for the professional to be familiar with this cutting- edge technology and its benefits in the dental world.
Global boundedness in a parabolic-elliptic system with chemotaxis and nonlocal term
Authors: Mao Shunlin
Published: December 2024

This paper focuses on a parabolic-elliptic chemotaxis model with nonlinear signal production and nonlocal term.
“NÃO, NÃO ME SENTIA REPRESENTADA, NEM UM POUCO”: ENTRE IDENTIDADES, DIFERENÇAS, ESCOLA E ENSINO DE BIOLOGIA
Authors: Dos Reis Neilton
Published: December 2024

Neste texto, apresento uma discussão no campo temático do processo de (re)(des)construção de Identidades, Currículo e Educação, no qual destaco e analiso o sentimento de pessoas estudantes se sentirem representadas na dinâmica escolar como parte fundamental para pensar essas construções e suas possibilidades de ampliação. Parto de entrevista com cinco estudantes de Ensino Médio que se identificam com a não binaridade de gênero e suas percepções sobre a escola para explorar quais os caminhos a Educação e a Ciência têm percorrido e selecionado quando se trata de gênero e sexualidade. Busco ainda lançar olhar às construções realizadas nas aulas acerca dos saberes sobre corpos, identidades e socializações. Com isso, proponho uma ação questionadora dos posicionamentos que as escolas têm assumido, de forma a repensar os contornos nos quais a pluralidade representativa pode ser trabalhada.
Conformal reconfigurable holographic metasurface for multifunctional radiation and scattering modulation
Authors: Zhang Xinyu , Gao Yuchen , Hu Wei , Luo Qi , Hong Tao , Xu Kai-Da , Jiang Wen
Published: December 2024

A reconfigurable holographic metasurface (HM) with multifunctional modulation of radiation and scattering for conformal applications is designed in this paper. Based on optical holography theory, a holographic conformal modulation mechanism is proposed, and the conformal surface impedance distribution of HM is derived. To illustrate this mechanism, the designed conformal reconfigurable HM is used to demonstrate a series of radiation and scattering modulation functions, with its reconfigurable property enabling dynamic beam control. In radiation mode, beam scanning with wide angle from −50° to 50° is achieved. In scattering mode, specific responses are generated under different incident angles, including beam steering under oblique incidence within ±60°, multi-beam splitting within ±60° under normal incidence, and diffuse reflection. Low radar cross section (RCS) is exhibited over a wide frequency band from 7.2 to 25 GHz. The designed conformal reconfigurable HM shows high adaptability to cylindrical platforms, insensitivity to oblique incidence, and stability in beam deflection angles, which provides an innovative technical approach for information transmission and stealth in conformal devices.
Factors influencing survival outcomes in patients with stroke at three tertiary hospitals in Zimbabwe: A 12-month longitudinal study
Authors: Kaseke Farayi , Gwanzura Lovemore , Musarurwa Cuthbert , Gori Elizabeth , Nyengerai Tawanda , Kaseke Timothy , Stewart Aimee
Published: December 2024

Background

In this longitudinal study, we aimed to determine factors influencing survival outcomes among patients with stroke at three tertiary hospitals over a 12-month period. The investigation sought to uncover influential determinants to enhance the precision of prognostic assessments and inform targeted interventions for individuals affected by stroke.

Methods

Employing a longitudinal study design, participants were observed for 12 months from baseline, censoring survivors at the endpoint. The dataset originated from a comprehensive study involving stroke patients treated at three referral hospitals in Zimbabwe: Parirenyatwa, Sally Mugabe, and Chitungwiza Central Hospitals. The primary outcome variable, the duration of survival until death, was measured in days from the initiation of stroke treatment. Gompertz parametric regression analysis was utilized for data modeling following AFT model diagnostics.

Results

In our study, 188 stroke patients were enrolled at baseline. However, 51 patients were excluded from the analysis due to either missing information or loss to follow-up. Among the remaining 137 patients who were tracked over a 12-month period, 42% were censored, and 58% were deceased. Individuals utilizing ’Free Service (older than 65/pensioners/retirees/social welfare)’ hospital bill payment methods showed a decreased risk of death, (adjusted hazard ratio; aHR: 0.4, 95% CI: 0.20, 0.80), suggesting a protective effect compared to cash paying patients. Those who had attained a secondary school level education displayed a significantly lower risk of death (aHR: 0.4, 95% CI: 0.24, 0.79) compared to those with primary level education. Age was a significant risk factor, with individuals aged 45–65 and those over 65 years showing higher adjusted hazard ratios 3.4 (95% CI: 1.42, 8.36) and 3.7(95%CI:1.44, 9.36), respectively, relative to those below 45 years of age. Housing status revealed a protective effect for those residing with parents/relatives (aHR: 0.4, 95% CI: 0.20, 0.64). Total functional outcome demonstrated significantly lower hazards for individuals with mild or moderate (aHR: 0.2, 95% CI: 0.09, 0.40) and severe outcomes (aHR: 0.2, 95% CI: 0.10, 0.46) compared to those with very severe outcomes.

Conclusion

The study findings demonstrate that hospital bill payment methods, housing status and staying with relatives, educational attainment, functional outcome, and age significantly affect survival outcomes among stroke patients. This highlights the need to consider socio-demographic and clinical variables in the development of prognostic assessments and targeted interventions for individuals recovering from stroke.