bluuebunny/crossref_metadata_2025 huggingface dataset:
Epileptic negative myoclonus in herpes simplex virus encephalitis
Authors: Fotedar Neel , Dolbow James , Layfield Madhura , Thyagaraj Suraj , Zande Jonathan
Published: May 2022

Epileptic negative myoclonus (ENM) is a rarely reported clinical seizure semiology. It is defined as a brief interruption of tonic muscle activity in association with an epileptiform discharge on the EEG (spike or sharp wave) without preceding myoclonia. The diagnosis of ENM requires a polygraphic recording with EEG and surface EMG electrodes covering the affected body part(s), while the muscles have tonic activity. Historically, ENM has been reported in a variety of chronic epilepsy syndromes such as benign epilepsy with centrotemporal spikes, progressive myoclonic epilepsy syndromes, symptomatic partial epilepsy syndromes due to structural pathologies, cryptogenic epilepsies, etc. In this paper, we report a patient with herpes simplex virus encephalitis who presented with multiple different seizure types including ENM. The patient showed significant improvement after treatment with acyclovir.
“İNSAN ONURU” NUN İNŞÂSINDA SEÇİLMİŞ IRK, İLÂHÎ VARLIK VE ERDEMLİ BEŞER DÜŞÜNCESİNİN YANSIMALARI
Authors: ATCI İsa
Published: May 2022

İnsan onuru, modern insan hakları düşüncesinin temel dinamiklerindendir. Zira bir hakka sahip olmak, onurlu olmayı gerektirdiği gibi; onurlu bir varlığın bazı temel haklara sahip olması da zarurîdir. Bu bağlamda insan, bütün mahlûkat içerisinde özel bir konuma sahiptir. Allah insanı onurlu yaratmış, ona ruhundan üflemiş ve melekleri ona secde ettirmiştir. Allah, en yüce varlıktır. En yüce olana yakınlık ise en büyük onur vesilesidir. Dolayısıyla insan psikolojisi açısından Allah’a yakın olma düşüncesi aslında yadırganacak bir düşünce olmadığı gibi bizzat Allah’ın teşvik ettiği bir husustur. Ancak yakın olmanın şekli ve insanların Allah’ın sevgisini kazanarak yüksek seviyede bir onura sahip olma düşüncesi ilâhî dinlerde farklı formüle edilmiştir. Yahudilik ve Hıristiyanlık’ta onur sahibi olma hususunda fizikî bir yakınlıktan bahsedilirken İslam’da manevî yakınlık ön plana çıkarılmıştır. Başka bir ifadeyle İslam, Yahudilik ve Hristiyanlığın ortaya koyduğu “Allah’ın çocukları” olma düşüncesini “Allah’ın kulları olma” şeklinde tasrih etmiştir. Bu çalışmada İslam hukuku açısından “şer'u men kablenâ” kapsamında değerlendirilen Hıristiyanlık ve Yahudilik ile İslâm’ın Allah tasavvurları ve bu dinlerin insan onuru bağlamında insana Allah nezdinde atfettikleri konum tespit edilmeye çalışılmıştır.
SOSYAL KAYTARMANIN DEDİKODUYA ETKİSİNDE TOKSİK LİDERLİĞİN ROLÜ
Authors: ÇİÇEK Berat , KAYNAK İnan
Published: May 2022

Bu çalışmada örgütler için ciddi sonuçları olan sosyal kaytarma, dedikodu ve toksik liderlik kavramları ele alınmış ve birbiri ile olan etkileşimleri incelenmiştir. Çalışma kapsamında 191 kişi ile anket çalışması yapılarak sonuçlar kısmi en küçük kareler (Partial Least Squares-PLS) temelli yapısal eşitlik modellemesi yoluyla analize tabi tutulmuştur. Analiz sonuçlarına göre, sosyal kaytarmanın dedikoduyu ve toksik liderlik davranışını pozitif yönde etkilediği ve toksik liderliğinde dedikoduyu pozitif yönde etkilediği sonuçlarına ulaşılmıştır. Ayrıca, toksik liderliğin sosyal kaytarma ile dedikodu arasındaki ilişkide tam aracılık rolü tespit edilen diğer bir sonuçtur. Son olarak çalışma süresinin sosyal kaytarma ile dedikodu arasındaki ilişkiyi düzenlediği sonucuna ulaşılmıştır.
Perspectivas y tendencias de investigación en emprendimiento social
Authors: Duque Hurtado Pedro , Ortiz Ortiz Doralice
Published: May 2022

Como mecanismo de creación de valor y solución a las dificultades latentes en la sociedad, el emprendimiento social puede ser una excelente opción de innovación y transformación para las empresas modernas. Este artículo realiza un análisis de redes para identificar las tendencias de investigación que surgen en la literatura sobre emprendimiento social. Para ello, se realiza una consulta en Web of Science y Scopus, y se procesa esta información mediante herramientas de mapeo científico como R y Gephi. Se identifican cuatro perspectivas en las que se enmarca actualmente el tema, las cuales, giran en torno al proceso organizativo, la evolución teórica, los fundamentos del emprendimiento social, y la vocación social de los emprendedores y las empresas para abordar problemas prioritarios del entorno. También se propone una agenda para futuras investigaciones.
Clemens Brentano’s “Sound-Thing” (Klingding)
Authors: Dembeck Till
Published: May 2022

Ce chapitre étudie « Der Einsiedler und das Klingding », poème satirique écrit par Clemens Brentano en 1808. Ce texte méconnu utilise la traduction homophonique comme moyen poétique afin de promouvoir l’ironie et le ludisme romantiques opposés à la délimitation restreinte et bourgeoise que s’imposent les Lumières tardives. Le poème de Brentano fut publié en plein débat sur le genre du sonnet dans la littérature allemande. Le principal objet de sa moquerie est Johann Heinrich Voß, célèbre traducteur d’Homère. Le texte contient de multiples sonnets, dont l’un est traduit homophoniquement du grec vers l’allemand. Cette étude cherche à reconstruire la stratégie politico-culturelle qui sous-tend la traduction de Brentano dans le contexte de sa critique satirique de l’esprit philistin de son époque.
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Steam turbine maintenance planning based on forecasting of life consumption processes and risk analysis
Authors: Rusin Andrzej , Tomala Martyna
Published: May 2022

Flexible operation of coal-fired power plants contributes to the intensification of the life consumption processes, which is a serious problem especially in the case of units with a long in-service time. In steam turbine rotors, the crack propagation rate and material wear caused by low-cycle fatigue increase. The aim of the research is an attempt to forecast the development of these processes and to estimate the probability of critical elements damage, such as the high-pressure and intermediate-pressure rotors. In the stress state analyses, the finite element method (FEM) is used, the Monte Carlo method and the second order reliability method (SORM) is apply to calculate the probability of failure. It is proposed to use risk analysis to plan preventive maintenance of the turbine. The optimal intervals for carrying out diagnostic tests and prophylactic repairs is determined for various operating scenarios and various failure scenarios. This enables a reduction of the costs while ensuring the safety of the turbine's operation.
La escritura académica en las carreras de educación en Ecuador: representaciones del alumnado
Authors: Boillos Mari Mar , Rodríguez Torres Ángel Freddy
Published: May 2022

Los estudios sobre escritura académica han puesto de manifiesto la necesidad de conocer cuándo, qué y cómo escribe el alumnado en los diferentes contextos y disciplinas universitarias, para poder llevar a cabo intervenciones didácticas que faciliten la adquisición de esta competencia. Este estudio exploratorio tiene como objetivo conocer las representaciones que los estudiantes de las carreras de Educación de las universidades de Ecuador tienen acerca de la escritura en sus realidades académicas. Para ello, se ha adaptado a dicho contexto la Encuesta Europea sobre la Escritura Académica y se ha aplicado esta a 942 estudiantes de 7 universidades del país. Los resultados apuntan a diferencias notables en la manera de entender la escritura académica en las distintas universidades. También se ve que las mujeres son más conscientes de la dificultad que entraña la escritura en la universidad y las diferencias con respecto a las etapas educativas precedentes. Se evidencia, además, la presencia de la escritura en las carreras de Educación en todas las universidades; que esta se utiliza como herramienta de evaluación de los saberes del alumnado y que no se aprovecha el feedback para el aprendizaje de la escritura. Las mujeres ven la necesidad de más cursos para aprender a escribir, de más ayuda en los cursos actuales y de más tutorías con profesionales y apoyo en línea. Estos resultados marcan las pautas para futuras acciones que deberían llevarse a cabo en el marco de la universidad ecuatoriana.
Factores que afectan la comprensión lectora de los estudiantes de educación básica y su relación con las TIC
Authors: Pérez Benítez Wilman Enrique , Ricardo Barreto Carmen Tulia
Published: May 2022

El artículo presenta los hallazgos de una investigación mixta, con diseño concurrente, sobre los factores que afectan la comprensión lectora de estudiantes de básica primaria de 10 instituciones educativas colombianas y su relación con las TIC. El objetivo último de la investigación era poder implementar procesos de mejora en las escuelas, que contribuyan a alcanzar una educación de calidad con los recursos disponibles. Para lograrlo, se utilizaron los resultados de la prueba estatal saber 9, durante los años 2015, 2016 y 2017. También se aplicó la encuesta de nivel de madurez en TIC en 10 escuelas de la muestra y se identificaron criterios cualitativos claves cuanti­ficados. Paralelamente, se aplicó la técnica de Metaplan® con 67 docentes en un establecimiento de la muestra, para recolectar las opiniones sobre los dominios y causas principales que afectan la comprensión lectora, los cuales se triangularon con la teoría reciente. Se concluyó que dos factores son necesarios para mejo­rar los desempeños en comprensión lectora de dichos estudiantes: a) la enseñanza explícita de las estrategias de comprensión lectora, y b) la integración de las tic para el aprendizaje. Se recomienda que estos dos factores sean focalizados priori­tariamente en los planes de formación docente y se materialicen en las escuelas, así como también en los programas de pregrado en Licenciatura en las universidades.
Evaluation of lactic acid fermentation in a dairy and non-dairy beverage using two commercial starter cultures
Authors: CORREA MOSQUERA ANA RUBY , CUENCA QUICAZAN MARTHA MARIA
Published: May 2022

Background: Lactic fermentations are a catabolic process in which biochemical transformations of different organic products occur. Sugars are mainly converted into organic acids, increasing viscosity, acid taste, aroma, and flavor. Lactic acid bacteria provide probiotic characteristics if they reach counts of 106 CFU*g-1 (Colony Forming Units) in the final product, which can generate wellness for consumers. Objective: This research aimed to compare the lactic fermentation process in three substrates using two commercial cultures. Methods: Whole milk (control), aqueous extract of oats flakes, and an aqueous extract of a mixture of oats flakes with mashua pulp were used. The whole milk was heated, and the aqueous extracts were prepared. All samples were divided into two parts, keeping the temperature at 42°C, and then inoculated with Yomix y Choozit. Each fermentation lasted 6 hours at 42°C. Fermentation samples were taken each hour, and pH, titratable acidity, and Brix degrees were determined. Results: Total lactic acid bacteria were counted at the end of each fermentation. The final product was evaluated with sensory analysis. As expected, there was an increase in titratable acidity and a decreased pH and Brix degrees. It was observed that the dairy product showed the most significant changes. Fermentations performed with Yomix presented a higher count of lactic bacteria. Conclusion: It is possible to carry out lactic fermentation using substrates that do not contain milk, requiring higher initial soluble solids and a longer incubation time.
Testing axial flow solar chimney turbine using wind tunnel
Authors: Elmagid Walid M. A.
Published: May 2022

The solar chimney power plant (SCPP) is a modernistic and promising technology, which utilizes the combination of solar heating and chimney effect for producing electricity. Solar collector, updraft tower and air turbine are the main components of a solar chimney unit, however, the turbine plays a royal role because it converts the kinetic energy of the heating air into useful mechanical energy. In this study, I measured the power, flow rate, rotational speed and pressure drop of the designed and industrial turbines within the wind tunnel, and the power coefficient of the turbines are calculated by measured values. The turbine was designed according to the blade element theory modified to consider the surrounding duct. we measured the electric power, flow rate and pressure drop of the turbine, and the power coefficient of the turbine is calculated by measured values. Testing of the designed and industrial turbine within wind tunnel shows that the highest power coefficient of the designed turbine is 0.45, while the highest power coefficient of the industrial turbine is 0.32. The designed turbine produces 28.89% higher than the industrial one.
Preventive prosthodontics – An overview
Authors: BS Vishnupriya , Nidawani Prakash , Galagali Girish , Naik Satyanarayana , R H Harsha
Published: May 2022

Preventive dental care is an important part of comprehensive dental care, preventive dental procedures are employed in the practice of dentistry and community dental health programs, that prevents the occurrence of oral diseases and oral abnormalities. It combines regular dental check-ups along with developing good oral hygiene habits. The effective prosthetic prophylaxis includes not only prevention of causes for alveolar bone loss leading to tooth loss but also preventing the defects of oral tissues. As a clinician our aim should not be just treating the area of interest, instead it should include the evaluation of mouth as a whole. This article brings out various concepts regarding preventive aspects of prosthetic dentistry such as prevention at every stage with special considerations in preventing alveolar bone loss.
Hollow denture-a solution to post covid total maxillectomy patients: A case report
Authors: Raveendran Anu , Raghuthaman Aswathi , Prema
Published: May 2022

Retention, stability and support are the basic principles on which the success of a complete denture. The ability lies in applying these principles professionally in cases with total maxillectomy that are narrow and constricted with increased interarch space. This will provide decreased support, retention and stability and also increased weight of the processed denture will compromise them further and try to dislodge denture. This article highlights a technique for the fabrication of a hollow maxillary complete denture in situation where there is no ridge tissue due to total maxillectomy followed by post covid mucormycosis. Weight of a denture may be a contributing factor to the successful resolution of a patient’s problem; the hollow denture can be considered as one of the treatment modalities. The advantage of a hollow maxillary or mandibular denture is the reduction of excessive weight of acrylic resin, which normally replaces lost alveolar ridge in the interridge space of the denture wearer. This clinical report describes a case report of Total maxillectomy patient with resorbed ridges where a simplified technique of fabricating a light weight hollow maxillary complete denture was used for prosthodontics rehabilitation.
Short implant in posterior maxilla with 2 years follow- up: A case report
Authors: Gupta Gaurav , Gupta D.K , Gupta Priyanka , Rana Kuldeep Singh , Chandra Neeraj , Shah Parth
Published: May 2022

Placement of the dental implants in posterior maxilla requires maxillary sinus floor elevation. However, this is avoided by placing short implant, these implants are increasingly being seen as an alternative to more extensive bone augmentation procedures. Long term follows up revealed survival of the implants. This case report describes extraction of teeth, followed by immediate placement of implantswiss short implant in posterior maxilla using jig trial in the prepared socket with two-year follow-up.
The effect of personality traits and parental attitudes on treatment in children and adolescents: a 6-month follow-up study
Authors: İLNEM Müjen
Published: May 2022

Objectives: This study aims to examine the effects of personality traits and parental attitudes on the change of emotional and behavioral problems in children and adolescents with mental disorders receiving outpatient treatment during the six months.
Methods: In the study, 233 individuals between the ages of 7-17 who applied to the Child Psychiatry Outpatient Clinic of a private hospital in Istanbul between September 2015 and September 2017 and who had psychiatric disorders regarding DSM-V diagnostic criteria were evaluated before treatment with the Sociodemographic Data Form, Strengths and Difficulties Questionnaire (SDQ), Quick Big Five Personality Test (QBFPT), and Parental Attitude Scale (PAS). Emotional and behavioral problems of children and adolescents who were followed up for psychiatric treatment were evaluated by SDQ at the first, third, and sixth months.
Results: According to the Pearson Correlation Analysis, it was found that the SDQ total scores of children and adolescents in the pre-treatment period were statistically significantly positively correlated with the Democratic Attitude subscale scores (r = 0.129, p = 0.049). Considering the QBFPT and PAS sub-dimension scores in ANCOVA analyzes, the change in the SDQ total scores before and after treatment was statistically significant (p < 0.05), and Democratic Attitude subscale scores (F = 2.70, p = 0.048) and Emotional Stability subscale scores (F = 3.27, p = 0.023) had statistically significant effects on this change.
Conclusions: In children and adolescents with mental disorders, focusing on democratic attitudes and personality traits associated with emotional stability may help reduce emotional and behavioral problems during treatment.
Przemiany małych miast w województwie pomorskim
Authors: Sołtys Jacek
Published: May 2022

W niniejszym rozdziale Autor prezentuje wyniki badań, których celem było rozpoznanie przemian małych miast w województwie pomorskim. Za wielkość graniczną miast objętych badaniem przyjęto 20 tys. mieszkańców. W województwie pomorskim takich miast jest 28. Przedmiotem badań są: przemiany demograficzne, powiązania z otoczeniem oraz przemiany gospodarcze mierzone zatrudnieniem. Metodą badań były analizy dostępnych danych statystycznych.
All Research Is LGBTQI Research: Recommendations for Improving Cancer Care Through Research Relevant to Sexual and Gender Minority Populations
Authors: Pratt-Chapman Mandi L. , Potter Jennifer , Eckstrand Kristen , Schabath Matthew B. , Quinn Gwendolyn P. , Dizon Don S. , Radix Asa
Published: May 2022

A growing body of research suggests lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI) people—referred collectively as sexual and/or gender minorities (SGM)—experience health disparities. While research is growing, limited evidence exists to inform patient-centered care for SGM people. The collection of demographic data is a cornerstone of quality assurance, yet collection of sexual orientation and gender identity (SOGI) data remains challenging and sparse. SGM people share with racial, ethnic, and other minoritized people stigma and suboptimal social determinants of health that may result in chronic stress and poorer health outcomes compared to cisgender, white, heterosexual people. Challenges are compounded for those who occupy multiple minoritized categories. The stigma and discrimination experienced by SGM are critically tied to behavioral risks related to maladaptive coping. Additionally, stigma impacts screening and other healthcare seeking behaviors. To advance SGM health equity, both clinicians and researchers need training on culturally appropriate collection of SOGI data and the relevance of these data to cancer prevention, screening, treatment, and survivorship.
A Didática e os desafios da formação do professor-pesquisador no contexto do mestrado profissional
Authors: Costa Elisangela André da Silva , Dantas Jeane Pereira , Miranda Freitas Bruno
Published: May 2022

A formação de professores-pesquisadores, no contexto dos cursos de mestrado profissional, é uma experiência vivida por muitos educadores que buscam na pós-graduação stricto sensu uma oportunidade de desenvolvimento profissional. A aprendizagem da pesquisa e a construção de conhecimento sobre a educação, no entanto, são perpassadas por desafios diversos relacionados às condições materiais de formação, de vida e trabalho dos mestrandos. Esta pesquisa objetiva refletir, a partir dos contributos da Didática, sobre os limites e as possibilidades da formação vivida por professores da educação básica vinculados ao Mestrado Profissional em Ensino e Formação Docente, ofertado por duas Instituições de Ensino Superior no Ceará. Metodologicamente, assenta-se na abordagem qualitativa, recorrendo à análise documental, com base em registros pedagógicos produzidos pelos mestrandos. Os resultados apontam que a vivência profissional é dialeticamente compreendida como limite e possibilidade dessa formação, permitindo concluir que o diálogo crítico entre a formação e a profissão é fundamental nesse processo.
The behavioural finance paradigm and the adaptive market hypothesis
Authors: Yousuf Zakhiyya , Makina Daniel
Published: May 2022

This study tests for the applicability of the Adaptive Market Hypothesis (AMH) and Bounded rationality theories on the Johannesburg Stock Exchange (JSE). This is in order to determine the influence of behavioural risk factors on the efficiency of the stock market. Behavioural theories show a gap in the theory of Efficient Market Hypothesis. Using quantile regression, our study established the applicability of the Adaptive Market Hypothesis on the JSE. Past market returns were shown to be significant in predicting future returns and thus did not follow a random walk. The lagged return increased at higher quantiles and differed with changes in market conditions (i.e. pre-financial crisis, financial crisis and post-financial crisis).  Thus, the predictability of returns varies with a change in market conditions. This paper is focused on only on the Johannesburg stock exchange in South Africa, more specifically the movement is the all share index. The findings should be able to be applied to emerging and developed economies. Business confidence is found to have a negative relationship with returns showing a lag in time for sentiment to be incorporated in prices. In contrast, consumer confidence is found to have a positive relationship with returns. In summary, investors are shown to be influenced by fundamental and behavioural factors.
DOES COVID-19 DRIVE ROBOT ACCEPTANCE? AN EXPLORATORY STUDY OF SERVICE ROBOT IN HOSPITALITY
Authors: Fahada W Ab Rahman N Alia , Mohamed Monizaihasra , Sulong Farizah
Published: May 2022

Purpose – The purpose of this study is to explore the acceptance of robots as social distancing agents and to understand how guests may respond to the application of service robots in a hospitality setting as a way to achieve a zero-COVID-19 travel experience. This study contributes to the current knowledge in the area of service robot application by providing a better insight of, and guests response to, service robot operation in hotels. Design/Methodology/Approach – To obtain information from participants, the semi-structured interview method was used. articipants were hotel guests who had stayed in hotels where robots performed human tasks. Data were analysed using thematic analysis. Findings – The findings suggest that robots are perceived as effective social distancing agents even though the participants experienced instances of robot incompetency during their stay at a hotel with robotics-based services. Participants also believe that with improved smart robot services, hotels can resume operations and guests can stay in hotels during the pandemic period without unnecessary worries. Originality – In light of the findings, some future research directions are suggested for researchers to further understand and explore the wider application of robotics in social distancing
On the Consistent Meaning of Local Realism
Authors: Lambare Justo Pastor
Published: May 2022

We analyze the different meanings currently assigned to the term ``local realism'' in the context of the conceptual and empirical violations of Bell-type inequalities. We point out that most of them are inconsistent and propose a possible correct connotation.
An Update on the General Features of Breast Cancer in Male Patients- a Literature Review
Authors: Ionescu Sinziana , Nicolescu Alin , Marincas Marian , Madge Octavia Luciana , Simion Laurentiu
Published: May 2022

Male breast cancers are uncommon, as men account for less than 1 percent of all breast carcinomas. Among the predisposing risk factors for male breast cancer, the following appear to be significant: a) breast/chest radiation exposure, b) estrogen use, diseases associated with hyper-estrogenism, such as cirrhosis or Klinefelter syndrome, and c) family health history. Furthermore, there are clear familial tendencies, with a higher incidence among men who have a large number of female relatives with breast cancer and d) major inheritance susceptibility. Moreover, in families with BRCA mutations, there is an increased risk of male breast cancer, although the risk appears to be greater with inherited BRCA2 mutations than with inherited BRCA1 mutations. Due to diagnostic delays, male breast cancer is more likely to present at an advanced stage. A core biopsy or a fine needle aspiration must be performed to confirm suspicious findings. Infiltrating ductal cancer is the most prevalent form of male breast cancer, while invasive lobular carcinoma is extremely uncommon. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. And randomized controlled trials which recruit both female and male patients should be developed in order to gain more consistent data on the optimal clinical approach.
A Narrative Review of the Pathophysiology of Mucormycosis Infection Among COVID-19 Patients in India: Epidemiology and Clinical Implications
Authors: Ramani Vinod , Naik Radheshyam
Published: May 2022

Background and Objective: During the second COVID-19 wave in India (April to May 2021), mucormycosis has affected the ‘recovering’ and the ‘recovered but vulnerable’ COVID-19 patients across the country. This review synthesizes information on the risk factors and pathophysiology of mucor infection among COVID-19 patients, which in turn supplements existing information from public health and clinical sciences. The study objective includes analyzing the morbidity of mucor infection and its pathophysiological mechanism, during India’s second wave of the COVID-19 pandemic.
Methods: We conducted a systematic literature search of PubMed and Google Scholar databases, using the following text terms: ‘COVID-19,’ ‘SARS-CoV-2,’ ‘mucormycosis,’ and ‘zygomycosis.’ We identified 24 citations and 16 other published literature which described mucormycosis in association with COVID-19. The relevant literature was analyzed for findings on the risk factors of mucor infection and its outcome among individuals with COVID-19.
Results: The risk factors for mucor infection include diabetes mellitus, immunosuppression (for example, the administration of steroids/monoclonal antibodies/broad-spectrum antibiotics), prolonged stay in the intensive care unit, co-morbidities such as malignancy or post-transplantation, and prophylactic therapy with voriconazole (generic anti-fungal). The second wave of COVID-19 in India was more severe due to the increased occurrence of systemic inflammation and coagulopathy, which can cause direct damage to the blood vessels resulting in injuries to organs such as the liver, kidney, and heart.
Conclusion and Implications for Translation: The increased incidence of mucormycosis during the second wave of the COVID-19 pandemic in India (April to May 2021) was due to a combination of immunocompromising effects of corticosteroids, microangiopathy of diabetes, and peripheral microthrombi among COVID-19 patients. The indiscriminate usage of steroids for treating COVID-19 disease seems to be the likely cause, including the use of immunomodulatory drugs such as interleukin 6 inhibitors like tocilizumab (TCZ) for patients with severe COVID-19. Clinical practices should adopt a judicious approach towards the prescription of steroids and monitoring blood sugar for all COVID-19 patients admitted to the hospital as well as those isolated at home (even during the post-recovery period). The high mortality rate of mucor infection demands appropriate primary prevention measures, as well as early diagnosis and treatment modalities for improving patient survival.
 
Copyright © 2022 Ramani et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Treatment with locking intramedullary nailing for intertrochanteric fracture of femur: application of a new guide awl with a distal positioner
Authors: Liu Binbin , Xu Fei , Liu Yang , Zheng Zehang , Xu Hanqing , Huang Chuang , Luo Zhengqiang
Published: May 2022

Background
The use of interlocked intramedullary nail has become the preferred method of treatment for intertrochanteric fracture of the femur. This study explored a new guide awl with a distal positioner assisting the guide wire insertion and opening canal, and verification the accuracy and security of our new guide awl.
Methods
42 patients with intertrochanteric fracture treated by locking intramedullary nailing were retrospectively analyzed. 19 patients underwent the operation using the new guide awl, the other 20 patients in the control group were operated with the help of the conventional guide apparatus. Three patients with insufficient follow-up were excluded from analysis. Describe the new guide awl with a distal positioner usage in the operations. Operation time, the success rate of one-time insertion, fluoroscopy time, blood loss and bone healing time were recorded.
Results
42 patients (25 males and 17 females) were treated with Gamma 3 and PFNA with the help of the new guide awl with a distal positioner or the conventional guide apparatus. The surgical time in new guide awl group was significantly shorter compared to the control group. The success rate of one-time wire insertion in the new guide apparatus group was 89.5%, which was higher than the 65% of the control group. The fluoroscopy time in new guide apparatus group is obviously lower than in the control group. There was no significant difference in intraoperative blood loss and bone healing time.
Conclusion
The new guide awl with a distal positioner we designed could reduce the difficulty in opening the femur for inserting the interlocked intramedullary nail. It is especially suitable for obese patients.
Impact of short segment fixation on Spinopelvic Sagittal Alignment in Thoracolumbar Fracture Cases
Authors: Li Kepeng , Ma Guoju , Zhao Heyi , Han Ye , Zuo Jinzeng
Published: May 2022

Background: Previous studies have reported the impact of thoracolumbar kyphosis induced by spinal burst fracture on spinopelvic sagittal alignment. But no study has analyzed the effects of short segment fixation on spinopelvic parameters in patients with spinal burst fracture. Thus, this study aimed to explore the impact of short segment fixation on spinopelvic sagittal alignment in patients with thoracolumbar fractures.Methods: Perioperative radiographs of 42 patients with thoracolumbar fractures treated with short-segment fixation surgery were obtained. The pelvic and spinal parameters were measured, and the influence of fracture site on all parameters was retrospectively analyzed. A descriptive analysis characterizing these parameters and multivariate analysis was performed to investigate the influencing factors of thoracolumbar kyphosis.Results: The mean age of included cases was 47.1±9.9 years, Pelvic incidence(PI) was 44.1±4.7º. Preoperative fractured level kyphosis (FLK) and thoracolumbar kyphosis(TLK) were 10.3±9.9º and 15.6±10.4º, respectively. Operative corrected degree(OCD) of FLK and TLK were 6.8±7.9º and 7.7±8.4º, respectively. Preoperative parameters, including FLK, TLK, Pelvic tilt (PT), Sacral slope (SS), Lumbar lordosis (LL), were no different in the different fracture sites. PT-OCD is greater in L2～L5 fractures than in T12～L1(t=0.82, P=0.03). FLK-OCD(B=0.36), LL-OCD(B=-0.34) and PT-OCD(B=0.22), as well as age(B=-0.23) were independent factors to influence TLK-OCD. Pelvis anteversion and high FLK-OCD was associated with a more satisfactory correction of the TLK deformity. TLK-OCD was negatively influenced by age. Conclusions: Short segment fixation surgery can correct TLK caused by fractures. Satisfactory TLK-OCD is related to excellent fracture reduction, pelvic anteversion, and younger patients. With FLK fixed by operation, the pelvis rotates from rear to front, more obviously in lumbar fractures. Trial registration: The trial was registered in the Iranian Registry of Clinical Trials ( www.irct.ir ) on 03/02/2019 as IRCT20180408039227N1.
Gold nanoparticles’ concentration dependent reactivity to alendronate, memantine, and tobramycin
Authors: Eissa Dina M. , Mabrouk Mokhtar M. , Ebeid El Zeiny M. , Hamid Mohamed A. Abdel
Published: May 2022

Turkevich Gold nanoparticles are the original nanoparticles that have been modified over time. Combining nanoparticles with targeting medications such as alendronate, memantine, and tobramycin will provide additional benefits in targeting specific areas in the bone, brain, and microorganisms, respectively. The reactivity and stability of nanoparticles in the presence of various drug concentrations (micro-, nano-, and milli-levels) have been studied. The absorbance spectra of nanoparticles at λmax 520 nm were always stable with alendronate, whereas with memantine and tobramycin, the spectra were unchanged (no color change) in the nano- level over twenty minutes and red shifts (color change) occurred in the micro-level. High Resolution Transmission Electron Microscopy (HRTEM) and Dynamic light scattering (DLS) revealed that the core diameter was relatively stable in all cases, whereas the hydrodynamic diameter and zeta potential varied with drug concentration. Increasing concentration increased hydrodynamic diameter slightly with memantine (from 64.99 to 98.41 nm), dramatically with tobramycin (from 135.3 to 332.16 nm), and almost negligibly with alendronate (from 52.08 to 58.94 nm). Zeta potential, conversely, is reduced as concentration increases. Memantine had the greatest reduction in negativity, followed by tobramycin, but alendronate had a slight increase in negativity. This research would be useful for the application of gold nanoparticles in targeted drug delivery, where stability and reactivity of gold nanoparticles are critical.
m6A-related lncRNA-based immune infiltration characteristics and prognostic model in colonic adenocarcinoma
Authors: Wang Hao-lun , Ye zhuo-miao , He Zi-yun , Huang Lu , Liu Zhi-hui
Published: May 2022

Background: Colonic adenocarcinoma (COAD) is a common gastrointestinal tract tumor, and its occurrence and progression are usually associated with genomic instability, tumor suppressor gene and oncogene mutations, and tumor mutational load.The biological importance of RNA N6-methyladenosine (m6A) modification and long non-coding RNA (lncRNA) expression in tumorigenesis and progression has been demonstrated. However, the regulatory role of m6A ‐ associated lncRNAs in the tumor microenvironment (TME) and the stratification of prognosis and immunotherapy have not been determined.Methods: We screened 43 prognostic lncRNAs linked to m6A and conducted consistent molecular typing of COAD using consensus clustering. The ssGSEA algorithm and the ESTIMATE algorithm were employed to assess the immune characteristics describing the different subgroups. Covariation between methylation-related prognostic lncRNAs was then eliminated by least absolute shrinkage and selection operator (Lasso) Cox regression. A nomogram was created and evaluated by combining the methylation-related prognostic lncRNA model with other clinical factors. And, the relationship between prognostic model grouping and microsatellite instability (MSI), immunophenotype score (IPS) and tumor mutation burden (TMB) was further validated using R language. Finally we used the linkage map (CMAP) to filter sensitive medicines to suppress the expression of high-risk genes.Results: Three separate m6A-associated lncRNA modes were discovered in 446 COAD specimens with different clinical endpoints and biological status. Risk scores were constructed based on m6A-associated lncRNA signature genes. Patients with lesser risk scores demonstrated superior immunotherapy response and clinical benefit. Further profiling suggested that lesser risk scores were also correlated with higher IPS scores, tumor mutation burden, and mutation rates in significant mutated genes (SMGs) (e.g., FAT4 and MUC16). Piperidolate, quinostatin, and mecamylamin were then screened for their ability to suppress expression of high-risk genes in the model.Conclusions: Quantitative assessment of m6A-associated lncRNAs in single tumors is expected to enhance our comprehension of the TME profile. M6A-associated lncRNAs constructed a prognostic model that facilitates prognosis and immunotherapy stratification in COAD patients, and based on the model we screened three drugs with potential therapeutic value.
Would you own a ROBOT? : A detailed research on public response to the nooks and crannies of owning a robot.
Authors: Dahal Ashim
Published: May 2022

The utility aspects of robots in our day to day tasks have been diminished over the fear of them taking over humanity, especially thanks to unrealistic movies. But how much should the public care about having or owning a robot? What tasks do we want robots to do? Which workforce do we want a robot to join? What are the privacy concerns of owning a robot? And given the circumstances of an economy sustained by our automated metal friends, will we still want to continue our jobs? In this research, we find answers to all these questions.
A Comparison of Re-admission and Emergency Department Visits in a Colorectal Surgical Home versus Traditional Perioperative Care
Authors: Couch Caroline A , Coleman Kristen L , Fellner Angela N , Guend Hamza
Published: May 2022

Purpose: A perioperative surgical home is a program that combines enhanced recovery protocols (ERP) with pre-operative optimization and intra-op protocols to improve outcomes post-operatively. There is no significant research on them in colorectal surgery. Our objective was to study the effect of a surgical home on re-admissions and ED visits of colorectal patients compared to traditional management. Methods: This was a retrospective study in a single system with multiple hospitals. The study group had elective colorectal surgery resection after the implementation of a colorectal surgical home that provided perioperative optimization. Patients were compared to those who underwent colorectal surgery resection with ERP but before the surgical home was established. Hospital re-admissions and ED visits within 30 days were then compared between the groups. Results: A total of 167 colorectal surgical home patient charts were compared to colorectal ERP patients only. The surgical home patients were younger than the ERP (61.6 vs 65.4). However, ASA scores and pre-operative comorbidities were very similar between the groups. The 30-day re-admissions and ED visits were improved but not statistically significant between the matched groups (10.2% vs 15.0% and 15.6% vs 19.8%) (p = 0.124 and p = 0.195). Secondary outcomes noted the surgical home group did have a lower length of stay and fewer conversions to open. Conclusions: Although there was no statistical significance between the 30-day re-admissions or ED visits, this trended towards improvement in patient treated under a surgical home when compared to those treated under ERP. ED visits decreased by 1/4 and re-admissions decreased by 1/3.
Risk stratification and prognostic value of multi-modal MRI-based radiomics for extranodal nasal-type NK/T-cell lymphoma
Authors: Zhao Yu-Ting , Chen Si-Ye , Liu Xin , Yang Yong , Chen Bo , Song Yong-Wen , Fang Hui , Jin Jing , Liu Yue-Ping , Jing Hao , Tang Yuan , Li Ning , Lu Ning-Ning , Wang Shu-Lian , Ouyang Han , Hu Chen , Liu Jin , Wang Zhi , Chen Fan , Yin Lin , Zhong Qiu-Zi , Men Kuo , Dai Jian-Rong , Qi Shu-Nan , Li Ye-Xiong
Published: May 2022

Background: Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It’s important to assess the value of multi-modal MRI-based radiomics for estimating overall survival (OS) in patients with ENKTCL.Methods: Patients with ENKTCL in a prospectively cohort were systemically reviewed and all the pretreatment MRI were acquisitioned. An unsupervised spectral clustering method was used to identify risk groups of patients and radiomic features. A nomogram-revised risk index (NRI) plus MRI radiomics signature (NRI-M) was developed, and compared with the NRI.Results: The 2 distinct type I and II groups of the MRI radiomics signatures were identified. The 5-year OS rates between the type I and type II groups were 87.2% versus 67.3% (P = 0.002) in all patients, and 88.8% versus 69.2% (P = 0.003) in early-stage patients. The discrimination and calibration of the NRI-M for OS prediction demonstrated a better performance than that of either MRI radiomics or NRI, with a mean area under curve (AUC) of 0.748 and 0.717 for predicting the 5-year OS in all-stages and early-stage patients. Conclusions: The NRI-M model has good performance for predicting the prognosis of ENKTCL and may help design clinical trials and improve clinical decision making.
Metal deposition and shape reproduction at biological temperatures on cell-level samples
Authors: Takemura Kenshin , Motomura Taisei , Iwasaki Wataru , Matsuda Naoki
Published: May 2022

The use of metal deposition has been limited to a limited number of applicable samples due to the increased temperature caused by accelerated electron impact on the substrate surface. The surfaces of various biological samples have a nanoscale structure with specific properties, which have been simulated in numerous studies. However, no examples of nano/microscale reproductions of biological surface features have used moulds. In this study, we successfully reproduced nano/micro shapes by forming metal nanofilms on bovine sperm, which were then used as moulds. Al thin films were deposited on bovine sperm using magnetron sputtering without thermal denaturation with a cathode operating at a biological temperature. The Al thin film was peeled off and used as a mould to reproduce the shape of the sperm with high accuracy using a polymer. The results of this study represent a major innovation in reproducible biomimetic moulding technology, demonstrating biological temperature sputtering. We expect our non-destructive metal deposition and metal nano-moulding methods for biological samples to be the basis for the effective utilization of various biological structures.
Using Microsatellite Data to Map the Persistence of Field-level Yield Gaps and Their Drivers in Smallholder Systems
Authors: Paliwal Ambica , Singh Balwinder , Poonia Shishpal , Jain Meha
Published: May 2022

One way to meet growing food demand is to increase yields in regions that have large yield gaps, including smallholder systems. To do this, it is important to quantify yield gaps, their persistence, and their drivers at large spatio-temporal scales. Here we use microsatellite data to map field-level yields from 2014 to 2018 in Bihar, India and use these data to assess the magnitude, persistence, and drivers of yield gaps at the landscape scale. We find that overall yield gaps are large (33% of mean yields), but only 17% of this yield gap is persistent across time. We find that sowing date, plot area, and weather are the factors that most explain variation in yield gaps across our study region, with earlier sowing associated with significantly higher yield values. Simulations suggest that if all farmers were able to adopt ideal management strategies, including earlier sowing and more irrigation use, yield gaps could be closed by up to 42%. These results highlight the ability of micro-satellite data to understand yield gaps and their drivers, and can be used to help identify ways to increase production in smallholder systems across the globe.
Disability-adjusted life-years and mortality rate for colorectal cancer attributable to dietary risk in Middle East and North African from 1990–2019
Authors: Darbandi Mitra , Shadmani Fatemeh Khosravi , Hamzeh Behrooz , Ghalandari Mojtaba , Moloudpour Behrooz , Pasdar Yahya
Published: May 2022

Background: Colorectal cancer (CRC) in low-income and middle-income countries, there is an increasing trend. This study aimed to estimate the burden of CRC attributable to dietary risk in the Middle East and North Africa (MENA) region.Method: In current study, data of the Global Burden of Disease (GBD) 2019 study were used to estimate the age-standardized mortality rates (ASMR) and disability-adjusted life-years (DALYs). We evaluated the 30-year trend of DALYs and mortality rate of CRC attributable to dietary risk, from 1990 to 2019 by sex and age groups, in 21 countries of MENA region.Results: Percent changes ASMR attributed to dietary risk for CRC in men and women were 8.32% and 3.44%, respectively. The percent changes related to DALYs/100,000 in men and women was 8.15% and 2.50%, respectively. The highest DALYs and ASMR were in the age group of 75-79. The highest percent changes of DALYs/100,000 and ASMR was observed in Afghanistan, Egypt, Iran, Iraq, Lebanon, Libya, Morocco, Palestine, Qatar, Saudi Arabia, Sudan and Yemen from 1990 to 2019. Trend of ASMR and DALYs attributed to diet high in red meat; low in calcium, low in milk, low in fiber and low in whole grain risk have been increasing for CRC.Conclusion: The DALYs and ASMR attributed to dietary risk for CRC has increased in 21 countries of the MENA regions from 1990 to 2019. Dietary modification with increasing fiber, dairy products and reducing red meat intake are highly recommended strategies in preventing CRC.