bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibacterial activities of seven ethnomedicinal plants from family Annonaceae
Authors: Harahap Diannita , Niaci Sarah , Mardina Vivi , Zaura Bintang , Qanita Intan , Purnama Agnia , Puspita Kana , Rizki Diva Rayyan , Iqhrammullah Muhammad
Published: May 2024

Serious threat to human health caused by bacterial infection persists as a global concern. It becomes more serious when the burden of multidrug-resistance bacteria is in the increasing trend. To overcome, researches have been conducted to develop antibacterial agents from plant-derived bioactive compounds. This review article focuses on the antibacterial activities of plant extracts from seven Annonaceae members, namely Annona muricata, Annona reticulata, Annona squamosa, Cananga odorata, Annona hypoglauca, Polyalthia longifolia, and Xylopia aethiopica. First, ethnomedical uses of the aforementioned plants are discussed and followed by the screening results of related phytochemicals. Among many secondary metabolites contained in the extracts of Annonaceae spp., anonaine, nornuciferine, and liriodenine are common and bioactive. The extracts were reported to have bacteriostatic and bactericidal properties against a wide spectrum of bacteria, including multidrug-resistant Escherichia coli, Staphylococcus aureus, Bacillus cereus, Enterococcus faecalis, Enterobacter aerogenes, Enterobacter cloacae, Salmonella choleraesuis, Salmonella typhimurium, and Shigella dysenteriae. We conclude that investigation on the extracts from Annonaceae spp. could contribute to the development of antibacterial agents that could be used against multidrug-resistant bacteria.
Evaluation of quality of obturation in 6–9-year-old children
Authors: Shathviha P Chithambara , Lakshmanan Lakshimi
Published: May 2024

The effectiveness of root canal therapy is dependent on the quality of obturation. The objective of the current study was to evaluate the obturation quality in pediatric patients of age 6–9 years reporting for pulpectomy treatment. Among the comprehensive data of patients attending Saveetha Dental College, a retrospective analysis of all the patients referred for pulpectomy was extracted. SPSS software version 19 was used to analyze the data gathered. Data were statistically evaluated using the Chi-square test. RESULTS: In the present study carried out, it was observed that the most frequent quality of obturation was normal (12.36%) and it is higher in the 7-year-old age category. The second frequent quality of obturation was voids (6.55%) and its higher in the 9-year-old age category. The results obtained were positively significant (P < 0.05). The most frequent quality of obturation was normal and it is higher in the 7 years category. The second frequent quality of obturation was voids with higher level in the 9 years category.
Association of crossbite with vertical skeletal growth patterns
Authors: Ramya G. , Jain Ravindra Kumar , Prasad Arya S.
Published: May 2024

Crossbite is a type of malocclusion in which teeth are positioned more buccally or lingually than their corresponding opposing tooth in the upper or lower dental arch, resulting in a lateral mismatch of the teeth in the dental arches. Crossbite can be unilateral or bilateral, and it can be anterior or posterior. The link between crossbite and skeletal growth pattern remains uncertain. The current study aimed to find the prevalence of crossbite in subjects visiting a private dental hospital and evaluate if there is any association between crossbite and skeletal growth pattern. Data required for the study were procured from the dental information archiving software. The data were sorted and entered into an Excel spreadsheet. IBM SPSS software version 23 was used to conduct the statistical analysis. Graphs and tables were used to interpret the findings. the prevalence of crossbite was found to be 6.4%. Subjects with horizontal growth pattern commonly had crossbite, but no statistical significance (P = 0.07), standard deviation (1.011), was noted. There was no statistically significant association between different skeletal growth patterns however subjects with horizontal growth pattern reported more commonly with crossbite.
Association of malocclusion and trauma in children
Authors: Jeyashree T. , Gurunathan Deepa , Padmapriya S.
Published: May 2024

Malocclusion is considered one of the most prevalent oral issues and it is considered one of the major risk factors for dental trauma. Dental trauma is a distressing experience for children, and they can have long-term physical, esthetic, and psychological effects. Hence, the main aim of this retrospective study is to evaluate the association between dental trauma and malocclusion in children. Four hundred and fifty patients between the age of 8 and 17 years during March 1, 2020–February 31, 2021, with Ellis classes 1, 2, and 3 were included in the study. Association of type of fracture with gender and malocclusion was calculated using Chi-square test. In case of Ellis class 1 fracture, 9.1% of the patients had no malocclusion, 21.8% of them had crowding, 11% of them had spacing, and 21.8% of them had anterior protrusion. In case of Ellis class 2 fracture, 4.3% of them had no malocclusion, 6.4% of them had crowding, 2.8% of them had spacing, and 3.6% of them had anterior protrusion. In case of Ellis class 3 fracture, 2.7% of them had no malocclusion, 6.4% of them had crowding, 4.6% of them had spacing, and 4.6% had anterior protrusion. The results were not statistically significant. Children with anterior protrusion and anterior crowding are more prone to severe damage during traumatic dental injuries.
Corticosteroids commonly prescribed in pediatric patients undergoing full-mouth rehabilitation under general anesthesia
Authors: Dharshini A. Divya , Govindaraju Lavanya
Published: May 2024

Dental treatment under GA is a compelling method for giving therapeutically important consideration to those youngsters who might be intellectually juvenile, exceptionally restless, medicinally split the difference, or unfit to get treatment in a customary office setting. While the traditional work on concerning corticosteroids is likely innocuous and perhaps gainful with lower prophylactic dosages and the nature of oral admission was additionally unaffected. The study aimed to investigate commonly prescribed corticosteroids in children undergoing full-mouth dental management under general anesthesia. A single-centered retrospective study among pediatric patients treated under general anesthesia of the age group of 0–13 years. The sample size is 124. Data were collected and tabulated. Data were statistically analyzed using the SPSS software version 23. Chi-square test and Pearson correlation were done using the software and P < 0.05 was considered statistically significant. The results show that 79.67% commonly prescribed dexamethasone, whereas 20.33% use hydrocortisone, providing the age groups between 0 and 3 has higher prescribing of corticosteroids. From this study, it is concluded that since the P value was more than 0.05, there is no significant statistical difference that has been analyzed. Dexamethasone is the commonly prescribed corticosteroid in children undergoing full-mouth rehabilitation under GA, followed by hydrocortisone.
Morphometric analysis of oculomotor triangle in dry human skulls and its clinical applications
Authors: Krishna B. Ashwin , Mohanraj Karthik Ganesh
Published: May 2024

The oculomotor triangle is denoted as the “Triangle of Hakuba” or the “Hakuba's Triangle.” This oculomotor triangle is a significant anatomical landmark. Oculomotor nerve, abducens nerve and part of the internal carotid artery (ICA) lie in this triangle. The determination of this analysis is to calculate the oculomotor triangle in dry processed skull bones of the south Indian population and its clinical significance. Fifty-one processed skulls of human origin were received from Anatomy Department, Basic Medical Sciences, Saveetha Dental College. Length from anterior–clinoid process (ACP) to posterior–clinoid process (PCP), length from PCP to APEX, and length from ACP to APEX were measured. Paired samples t-test was considered to analyze the values between the right triangle with the left triangle. From the measurements taken, the mean for the left side of the oculomotor triangle, ACP to PCP was 8.0591 ± 0.52 mm and the right side was 7.5482 ± 0.52 mm. The mean left side of the oculomotor triangle, measured from PCP to APEX was 6.73 ± 0.48 mm and the right side was 6.55 ± 0.72 mm. The mean of the left side of the oculomotor triangle, measured from ACP to APEX was 15.94 ± 0.682 mm and the right side was 16.21 ± 0.747 mm. Through this paired triangle of the cranial cavity, the horizontal section of ICA may be correlated with numerous vascular-related pathological considerations.
High frenal attachment and its prevalence among children - A retrospective study
Authors: Mary Angel Fastina , Govindaraju Lavanya
Published: May 2024

The frenum is a narrow mucosa fold surrounded by muscle fibers that connect the lips to the alveolar mucosa and the periosteum beneath. Midline spacing, commonly called as diastema, recession, interference with prosthodontic therapy, and difficulty speaking are all symptoms of a high frenal attachment. Frenectomy is a surgical treatment that involves removing the aberrant frenal connection. The frenum is a connective tissue membrane that connects one mouth surface to the next. The purpose of this study is to see how popular high frenal attachment is among children who visit a university dentistry hospital. This was a retrospective investigation evaluating the prevalence of high frenal attachment in patients visiting a Chennai dental institution. From June 2019 to March 2021, 11278 patients visited a dental clinic.
Awareness on three-dimensional printing of orthodontic appliances among dental students
Authors: Chandran Jayadharani , Balakrishnan Nivethigaa , Sreenivasagan Swapna
Published: May 2024

The aim of the study was to evaluate the knowledge and awareness regarding the use of three-dimensional (3D)-printed appliances used in orthodontics among students pursuing dentistry. The distribution of the questionnaire was done using an online Google Forms link to about 100 dental students. The questionnaire compromised questions that were designed for assessing the various findings and knowledge of update, and finally, questions related to facts on various 3D-printing appliances. Among the total population, 58% of the population are aware of 3D printing used for various dental applications, whereas 42% of the population are not aware of the same. Among the total population, 58% of the population are aware of 3D printing used in dentistry, whereas 42% of the population are not aware of 3D printing used in dentistry. Inside the limits of the review, it very well may be inferred that 3D-printed machines have a rising use in the majority of the dental fields and understudies chasing after dentistry know about it. The knowledge about the basic and fundamental working and the usage of such appliances is developing among undergraduate students. Further continuing education programs can be provided to improve the same.
Prevalence of usage of various removable appliances among undergraduate dental students in a private dental college
Authors: Pradeep Malavika , Balakrishnan Nivethigaa , Arvind T. R. Prasanna
Published: May 2024

The aim of the present study was to assess the prevalence of usage of various removable appliances among undergraduate dental students in private dental colleges. Ethical approval for the study was obtained from the Institutional Review Board of Saveetha Institute of Medical and Technical Sciences, Chennai, India. A dental record of patients was investigated. Data evaluation was completed and entered into Microsoft Excel. Gender distribution among the cohorts was assessed. The most commonly used appliance is Hawley's appliance (61), followed by Essix retainer (25), Begg's wrap-around retainer (23), Hawley's appliance with tongue crib (16), cantilever spring (7), splint (7), and T spring (1), respectively. The majority of the females (36) took Hawley's appliance. The difference was not statistically significant between both the arches and between the male and female population. Hawley's appliance is the most commonly used removable appliance among dental graduates.
Comparison of hematological parameters among chronic periodontitis patients and healthy individuals
Authors: Timothy Chris Noel , Rajasekar Arvina
Published: May 2024

Some of the most common oral disorders are periodontal disease. Variation in hematological parameters in chronic periodontitis patients could affect the type of treatment and its overall outcomes. Comparing and evaluating the hematological parameters in people with chronic periodontitis and the general population was the aim of this study. 100 individuals with chronic periodontitis (Group I) and 100 individuals in clinically good health participated in the study (Group II). Hemoglobin (Hb), random blood sugar (RBS), bleeding time (BT), and clotting time (CT) were evaluated and compared between the two groups. In contrast to patients with chronic periodontitis (8.934 ± 2.0), in healthy patients, the mean Hb concentrations were found to be higher (13.435 ± 1.8). In comparison to healthy individuals (98.98 ± 25.42), patients with chronic periodontitis had a higher mean value for RBS (112.14 ± 47.5). In contrast to the healthy population (BT = 2.654 ± 13.36, CT = 6.057 ± 0.267), patients with chronic periodontitis had shorter mean BT and CT (BT = 0.301 ± 0.07, CT = 2.84 ± 0.6058). Hematological factors and the population's periodontal health were discovered to be significantly associated (P = 0.001). Within the constraints of the continuing investigation, it was shown that among people with chronic periodontitis, Hb levels, BT, and CT were reduced, while blood glucose levels were increased.
Combination therapy using advanced biomaterials in the management of mandibular Grade II furcation defect
Authors: Navya Paladugu Devi , Rajasekar Arvina
Published: May 2024

Periodontitis is a multifactorial disease. Even though plaque is a primary etiological factor; there are so many aggravating factors such as calculus, genetics, lifestyle habits, systemic health, and occlusal trauma. Trauma from occlusion is caused by occlusal force that surpasses the periodontium's adaptive capacity, causing injury to periodontal structures. This case highlights the management of a furcation defect of Grade II which was induced by occlusal trauma. The patient presented with periodontal abscess in relation to 36 and on radiographic examination, bone loss and high points were evident in relation to endodontically treated 36. A full-thickness mucoperiosteal flap was elevated and after debridement injectable platelet-rich fibrin (iPRF), osseograft, and guided tissue regeneration (GTR) membrane were placed. The patient was recalled after 3 months for re-evaluation. On re-evaluation, the radiograph showed adequate bone fill which suggested that using iPRF, bone graft, and GTR may enhance periodontal regeneration in Grade II furcation defects. Therapy using iPRF, bone graft, and GTR may enhance in Grade II furcation problems, and periodontal regeneration is possible.
Awareness on hematological malignancies among college students
Authors: Jibu Ritya Mary , Veeraraghavan Vishnu Priya , Gayathri R. , Kavitha S.
Published: May 2024

Cancers of blood arise when the abnormal blood cells undergo uncontrolled growth which outpaces the natural production of normal blood cells, interfering with the cells' normal functions. Leukemia, lymphoma, and myeloma are the three types of blood cancers. The aim of our study is to assess and create awareness of hematological malignancies among college students. A questionnaire was prepared using Google Forms based on the awareness of the Hematological malignancies disinfection methods among dental students in Chennai. It was then circulated among a certain set of participants using an online Google Form link. The participants were asked about their knowledge level regarding hematological malignancies and a majority (68.97%) were aware of the same, whereas 27.59% were not aware and the rest (3.45%) were not sure. When asked about how dental care detects various hematological malignancies, 10.34% of the participants replied as “patient speaks about any abnormality,” 75.86% replied as “oral manifestations,” and 13.79% replied as “dentists cannot detect hematological malignancies.” From the above results and discussion, we can come to the conclusion that most of the dental students who participated in the survey are aware of hematological malignancies and its various types.
An in vitro analysis on the antioxidant and anti-diabetic properties of Kaempferia galanga rhizome using different solvent systems
Authors: Vishaka S. , Sridevi G. , Selvaraj J.
Published: May 2024

Kaempferia galanga rhizome (KGR) is a stemless, sweet-smelling, enduring, and rhizomatous monocotyledonous plant of the ginger family also called sand ginger or kencur. lt possesses many pharmacological effects and the goal of this study is to use several solvent solutions to determine the antioxidant and anti-diabetic potential of KGR. By observing KGR's alpha-glucosidase and alpha-amylase inhibitory activity, the in vitro diabetic activity was assessed. The in vitro cancer preventive action was evaluated by doing the 2,2-diphenyl-1-picrylhydrazyl test. The outcomes of the study showed increase in dose-dependent percentage of inhibition in α-amylase and α-glucosidase activity for both extract and standard ranging from 100 to 500 μg/ml. The current review proposes that the concentrate of KGR could be utilized for the treatment of diabetes mellitus as well with respect to dealing with the oxidative stress-related diseases.
The color improvement of postdebonding white spot lesions after fluoride and casein phosphopeptide– amorphous calcium phosphate application
Authors: Anggani Haru Setyo , Arifiani Putri , Siregar Erwin
Published: May 2024

White spots are common side effects of orthodontic treatment, and their presence after debonding appears unesthetic. This study aimed to quantify and compare the visual improvement in postdebonding white spot lesions following fluoride and casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) application. The sample included 42 upper premolars extracted for orthodontic reasons. Universal premolar brackets were bonded to the facial surfaces of the teeth that were exposed to a demineralization solution to create artificial white spot lesions, after which the brackets were debonded. The specimens were randomly allocated to three treatment groups (n = 14, each): acidulated phosphate fluoride (APF) gel application group; CPP–ACP paste application group; and control group. pH cycling was conducted to all groups for 14 days. Quantitative measurements were carried out using a spectrophotometer at the following times: before and after the white spot lesions artificially formed and after treating them. All groups showed significant differences in color change before and after treatment. However, there was no significant difference in the color improvement between the APF gel and CPP–ACP paste application groups. Although CPP–ACP application improved the color of the white spot lesions, it did not differ significantly from that of fluoride application.
Wound-healing activity and quantification of bioactive compounds from Derris scandens extract
Authors: Somwong Pathom , Kamkaen Narisa
Published: May 2024

Derris scandens (DS) is a Thai herbal medicine used to relieve musculoskeletal pain. It has been found as a single crude medication, ethanolic extract, and compounded herbal recipe for oral administration in pharmacies across the country. Due to its medicinal benefits and enriched phytochemicals, researchers are now drawn to examine the new pharmacological effects of this plant to increase its usage in complementary medicines. The purpose of this research was to investigate the wound-healing properties of the plant's ethanolic extracts as well as their active chemical composition. The extracts (both 50% and absolute ethanol) prepared by Soxhlet extraction were examined for cytotoxicity and wound-healing activity using human skin fibroblast cells, and the active chemical contents in the extracts were analyzed further using the HPLC method. For this study, genistein and lupeol compounds were selected as chemical markers. In the concentration range of 0.0001–1 mg/mL, all extracts had no cytotoxic effects on the examined cells, and 1 mg/mL of both ethanolic extracts was effective for wound closure in a scratch assay. The phytochemicals genistein and lupeol were found to be 0.0332% and 0.0588% (w/w) in the 50% ethanolic extract, respectively, and 0.0309% and 0.3472% (w/w) in the absolute ethanolic extract. The ability of DS extracts containing these compounds on in vitro wound-healing activity was demonstrated in this study.
Comparative analysis of pink and white esthetics of anterior full veneer crown
Authors: Merchant Aman , Maiti Subhabrata , Rajaraman Vaishnavi , Velayudhan Ashok , Ganapathy Dhanraj M.
Published: May 2024

A goal of modern dentistry is to make an esthetic outcome as one of the major modalities in dental treatment. In recent years, more emphasis has been given to esthetic parameters, especially in the anterior regions. The aim of this study was to evaluate the presence of change in pink and white esthetics scores after giving crowns in a single tooth. Subjects for this retrospective study were chosen by randomization from June 2019 to May 2020. A total of 120 subjects were selected which were equally divided with respect to age and gender. The analysis was done with a photographic assessment. The study test was done using paired t-test, and the correlation was evaluated using the Chi-square test. In this study, we observed that there is an increase in pink and white esthetic scores (WES) after the prosthesis is delivered. There was a clinical and statistically significant difference seen with the WES and total score, whereas only clinical but no statistical difference was seen with the pink esthetic score. After giving crowns, there is an increase in overall esthetic score. It is important to have certain standardized indices to score esthetics by which the overall esthetic outcomes can be improved. One such popular index is the pink and white esthetic index, which scores the soft and hard tissue.
Stature estimation using the odontometric measurements of the maxilla
Authors: Panigrahi Chandan , Babu K. Yuvaraj
Published: May 2024

Stature is the height of an individual in an upright position. It is one of the key characteristics, which helps in defining any individual. Stature estimation is needed mostly in medicolegal cases where only a limited number of human fragments are left for forensic analysis. The teeth provide essential measurements that can be used to determine stature. The aim of the study is to find out whether the second maxillary interpremolar distance can be used to effectively estimate stature of individuals. For the study, the sample size taken was 60 (30 male and 30 females), and their second maxillary interpremolar distance was measured using a digital vernier caliper. The collected data were tabulated and statistical analysis was done using SPSS software (23), followed by linear regression. For male: Y = 178.65 − 1.09X, correlation coefficient, r = 0.05, For female: Y = 169.30 − 1.99X, correlation coefficient, r = 0.13. Since r < 0.2, there is no correlation between the interpremolar distance of the second maxillary premolar and the stature. From our study, we conclude that the interpremolar distance of the second maxillary premolar cannot be a reliable parameter for stature estimation in both genders.
Synthesis and cytotoxicity of the boron carrier pentagamaboronon-0-ol for boron neutron capture therapy against breast cancer
Authors: Utomo Rohmad Yudi , Wulandari Febri , Novitasari Dhania , Susidarti Ratna Asmah , Kirihata Mitsunori , Hermawan Adam , Meiyanto Edy
Published: May 2024

Boronic acid-containing curcumin analog, pentagamaboronon-0 (PGB-0), acts as a potential boron-carrier agent but has limited water solubility. Thus, a new compound (PGB-0-ol) with better chemical and pharmacological properties than PGB-0 has been synthesized. Molecular docking was performed using a molecular operating environment. Prediction of PGB-0-ol absorption, distribution, metabolism, and excretion (ADME) was performed using pkCSM software. PGB-0-ol was synthesized by adding NaBH4 to PGB-0 and stirring for 1 h. The crude PGB-0-ol was purified using preparative layer chromatography. Cell viability was evaluated using the trypan blue exclusion assay. In comparison to PGB-0 based on molecular docking study, PGB-0-ol could interact in with several cancer biomarkers, such as human epidermal growth factor2 epidermal growth factor receptor, IκB kinase, folate receptor-α, and integrin αvβ3. PGB-0-ol also showed an improved ADME profile because of its higher water solubility than PGB-0. PGB-0-ol was synthesized by selective ketone reduction of PGB-0 into primary alcohol by sodium borohydrate producing 30% yield. The cytotoxicity of PGB-0-ol against several breast cancer cells was lower than that of PGB-0. The novel compound PGB-0-ol was synthesized using simple steps. PGB-0-ol has low cytotoxicity against breast cancer cells and could be applied in boron neutron capture therapy as a boron carrier.
Evaluation of occlusal pattern in periodontitis patients using T-scan analysis
Authors: Deepika B. A. , Ramamurthy Jaiganesh
Published: May 2024

Occlusal analysis is important to analyze any disharmony in occlusion. Atraumatic dental occlusion leads to evolution of T-scan. T-scan gives a valuable procedure for clinical assessment and perception of occlusal problems. T-scan can also be used in periodontitis patients for checking the occlusal pattern. Occlusal problems and periodontal disease relationship remains controversial. Further research is needed to determine whether occlusal adjustment is necessary for periodontal treatment. The main aim of the study was to assess the occlusal pattern using T-scan in periodontitis patients. Thirty periodontitis subjects were taken and checked for occlusion using T-scan. The subject's age group was 35–55 years. The study included 15 males and 15 females. Plaque index, gingival index, attachment loss, probing depth, centric occlusion (CO), protrusion, right lateral, and left lateral were the parameters studied. Occlusal adjustments were needed to decrease and dissipate the abnormal occlusal forces. The significance of statistical tests for various movements are as follows: CO (right and left) (P = 0.077) P > 0.05; protrusion (right and left) (P = 0.09) P > 0.05; left side lateral (right side and left side) (P = 0.01) P < 0.05; right lateral (right side and left side) (P = 0.00) P < 0.05. CO and protrusion (right, left) for males and females are not significant. Left lateral and right lateral (right, left) for males and females were significant. The T-scan manages adequate specificity and sensitivity. Hence, these act as a distinctive tool for diagnosis and better unreliable when used intraorally. The T-scan method is definitely a valuable tool for examining and evaluating the occlusal contacts during maximal intercuspation.
Knowledge, awareness, and practice of biomedical waste segregation in a dental office
Authors: Janani K. , Jayaraman Mahalakshmi
Published: May 2024

Biomedical waste (BMW) is any sort of litter generated in the course of human or animal research operations, such as diagnosis, treatment, or immunization, or during the development or trial of pharmaceutical products or in health camps. In dental sectors, BMW, if not adequately handled, can provide a number of health risks to dental practitioners, patients, and other dental healthcare service providers who operate in dental offices. The aim of the study is to examine the knowledge, awareness, and practice of BMW segregation among dental offices. A well-framed questionnaire containing 10 self-structured questions was formed and distributed among 100 students of dentistry through an online Google Forms link. The results were collected, tabulated, and statistically analyzed using the Software SPSS. Chi-square test was performed to assess the P value. Biological waste segregation was known to 98% of the participants, in which most of them had more than 10 years of expertise in dentistry. It is evident that dentists with a lot of experience over the years in the field of dentistry possess considerably increased awareness regarding the segregation of BMWs in their dental offices. Chi-square test done between the years of experience in dentistry and the knowledge on BMW segregation reveals that 0.031 < 0.05 is the P value, which is statistically significant. Most dentists having experience of above 10 years in the field of dentistry have excellent knowledge and practice of segregating BMWs in their dental offices.
Knowledge and awareness on neurolept anesthesia among dental students
Authors: Ushanthika T. , Vikraman Rakshagan , Ganapathy Dhanraj M. , Duraisamy Revathi
Published: May 2024

N20 omission or addition to the combination of an opioid and neuroleptic is referred to as neuroleptanalgesia and neuroleptanesthesia, respectively. Conscious sedation is the result of this evolution. The requirement for high-quality anesthesia that is also related with speedier recovery, improved comfort, and lower costs all support the concept of neuroleptanesthesia. A set of eight questions was formulated and circulated among the undergraduate and postgraduate students of Saveetha Dental College. Responses were collected and the data were entered into MS Excel sheet and transferred to SPSS for the analysis. Results were made into graphs and interpreted. In the present study, among the students who took part in the study, 36.3% of the students were postgraduates and 63.7% of them were undergraduates. About 45.2% of the students were not aware and 54.8% of the students were aware that neuroleptanalgesia refers to the combination of a potent sedative analgesic agent and a tranquillizer. Many of the students were not aware of what neuroleptic esthetic is and how it evolved. The current study showed that most students did not have enough knowledge about neurolept anesthesia. However, dentists should make efforts to improve knowledge, awareness of neurolept anesthesia for further advancement, and the need for high-quality anesthesia.
Comparative analysis of the dispersion quality of oxymetazoline nasal sprays
Authors: Gobyzov Oleg A. , Ryabov Mikhail N. , Yankova Viktoriya G. , Gribanova Svetlana V. , Slonskaya Tatiana K. , Udyanskaya Irina L. , Zhukova Anna A. , Grigoryeva Viktoriya Yu.
Published: May 2024

Metered-dose nasal sprays (MDNS) are the most widely used for treating rhinitis. Medicinal preparations in the pharmaceutical market vary in their characteristics. To identify the most effective drug, it is necessary to compare the preparations regarding various parameters. The purpose of the research was to compare oxymetazoline MDNS of different brands regarding their dispersion qualities. To that end, nine oxymetazoline sprays available in the Russian market were chosen and analyzed considering their dynamic characteristics and the spraying dispersion composition. The research was conducted with the shadow photography method, the selection of which was justified by its simplicity, the possibilities for detecting the spray jet composition, the process of its formation in dynamics, and the possibility for measuring droplets of all forms. Momentary images of spray activation phases, as well as an averaged image of 100 shots of the spraying main phase, were obtained. According to a range of characteristics, such as spraying duration, a cone angle and cone structure, all the preparations were grouped into three categories. It was found out that the sprays from Group 2 had the best dynamic rates of dispersion, with Vicks Sinex having the best results. Regarding the distribution of particles of different size, the most optimal composition was found for the drugs from Group 2, particularly, Vicks Sinex and Afrin preparations. Hence, Vicks Sinex spraying regimen and microsprayer design were found the most effective for delivering the medicinal substance to the destination.
Time-kill kinetics and antimicrobial activities of Thai medical plant extracts against fish pathogenic bacteria
Authors: Techaoei Surachai
Published: May 2024

The main objective of this work was to conduct the microbial control of Thai herbs against fish pathogens and their time-kill kinetics activity. Ten medicinal plants were selected to test antimicrobial activity against aquatic pathogens including Aeromonas hydrophila, Flavobacterium sp., and Streptomyces sp. Caesalpinia sappan and Alpinia galangal extracts showed the best activity against A. hydrophila and Streptomyces sp. Among them, Caesalpinia sappan expressed the great activity against A. hydrophila and Streptomyces sp. with the test concentration of MIC values of 1.25 and 2.50 mg/mL and MBC values of 5.0 and 10.0 mg/mL, while the MIC and MBC values of A. galangal were found to be 2.50 and 10.0 mg/mL with Streptomyces sp. The plant extracts of C. sappan and A. galangal at 1MIC, 2MIC, and 3MIC values really showed time-kill kinetics potential against fish pathogen on period of 3–18 h. In conclusion, plant extracts are good potentials sources as antifish pathogens and safety in an aquatic ecosystem.
Improving of pelB-Secreted MPT64 protein released by Escherichia coli BL21 (DE3) using Triton X-100 and Tween-80
Authors: Kusuma Sri Agung Fitri , Subroto Toto , Parwati Ida , Rukayadi Yaya , Fadhlillah Muhammad , Pardede Ruth Michellee , Berlian Alif Virisy , Sabila Gina
Published: May 2024

pelB has been known as a successful signal peptide to translocate the protein target extracellularly in the Escherichia coli system. However, in our previous study, the yield of MPT64 protein extracellular recovery was still low and plenty of this protein was remain trapped in cytoplasm and periplasm. Recently, nonionic surfactants were efficiently reported to secrete recombinant protein extracellularly. Nonetheless, it must be clarified whether the surfactant supplementation can improve the yield of MPT64 extracellular protein significantly without giving impact on the structure of isolated MPT64 protein and can minimized the cell lysis effect. MPT64 protein secretion was carried out by comparing the effects of surfactants Tween 80 and Triton × 100 at various concentrations. Triton × 100 was able to increase the extracellular MPT64 protein gain up to 3 times higher than Tween 80 and it was in line with the greater level ratio of cell leakage of Triton × 100 compared to that of Tween 80. Similarly, the viable cell of the cultures decreased dramatically. However, both surfactants did not interfere the structure of MPT64 protein. In conclusion, Triton × 100 can be chosen as the supporting surfactant to assist the act of peptide signal in improving the resulting of MPT64 extracellular protein.
Characterization and in vitro release of inhalation quercetin solid lipid microparticles
Authors: Rosita Noorma , Ambarwati Nadya , Erawati Tristiana , Hariyadi Dewi Melani
Published: May 2024

This study purposes to develop solid lipid microparticles (SLM) inhalation delivery system for respiratory diseases with Quercetin as the active agent. Quercetin has various functions, such as for antioxidant, anti-inflammatory, immunomodulator, and antivirus. SLM is formed from a mixture of lipids and surfactants, namely, Glyceryl Behenate as solid lipid, Poloxamer 188 as the surfactant, and production of SLM using the melt o/w emulsification technique and was dried using freeze dryer. The effect of lipid concentration was studied in this research. Quercetin SLM was characterized by moisture content, Fourier transform infrared, particle size, yield, drug loading, and encapsulation efficiency. The SLM particles produced were spherical in shape and had a smooth surface with sizes of F1, F2, and F3 were 1.79 μm, 1.88 μm, and 1.91 μm, respectively. According to the target particle size of inhalation, Quercetin SLM had good flowability according to Carr's Index (F1 = 12.73% ± 0.38, F2 = 14.28% ± 0.65, F3 = 14.65% ± 0.62), in which the highest drug loading and EE of F3 were 10.94% and 88.48%, respectively. In vitro release study showed that in 630 min about 31%–33% Quercetin released indicated sustained release following Higuchi kinetics and quercetin release rate was not affected by the amount of lipid. To sum up, quercetin SLM demonstrates its potential as an inhalation delivery system and it is recommended to study its stability.
Effect of carbonated beverages on the color stability of bulk and flowable composite resin
Authors: Noufal Z. Mohamed , Ganesh S. Balaji , Jayalakshmi S.
Published: May 2024

Tooth discoloration is considered as one of the most common dental problems among people, and in dentistry, the most common cases are claimed after the restoration. Therefore, in this research, we aim to evaluate the effect of carbonated beverages on the color stability of bulk and flowable composite resin. For the study, 12 composite disc samples were made using the standard dimensions of 10 mm diameter and 2 mm thick. To find the color stability, we used a VITA Easyshade spectrophotometer. We used two different composites of bulk fill and flowable composite resin; the composite brand we used was Tetric ecom plus; as an immersion medium, we used two different carbonated beverages, and the chosen beverages were Appy Fizz and 7Up. 24-h and 7-day postimmersion color stability was evaluated. In the results of postimmersion, we have found the Delta E value for 24 h immersion of flowable and bulk fill composite as 5.8115 and 7.4378, respectively; similarly, the Delta E value for 7 days immersion of flowable and bulk fill composite was 9.9559 and 10.1028, respectively. Using the independent “t”-test, we found that the significance is 0.633 and 0.328, which was statistically not significant. In the present study, when immersed in Appy Fizz juice and 7Up juice, bulk fill composite resins have shown greater discoloration when compared to flowable composite resin material. Thus, the flowable composite resin samples were more color stable.
Practice management in undergraduate dental program
Authors: Priyaa N Padma , Jeevanandan Ganesh , Govindaraju Lavanya
Published: May 2024

The objective of this study is to assess the opinion of dental students regarding the necessity for a practice management (PM) course in their curriculum. To determine the necessity of a PM course in dental programs, a series of questions was developed and given to 100 dental students. Dental students were asked a series of questions about the necessity of this course, and responses were gathered. The questionnaire included time management, patient management, teamwork, leadership quality, and other requirements of the course. According to the results, dentistry students desired that the PM curriculum cover subjects such as teamwork, confidence, the value of the PM course, time management, patient management abilities, leadership qualities, and others. Most of the responses obtained from the students agreed that the PM curriculum must be taught with the course for better management. The development of any course should be based on the need and opinion of the students who pursue the course of dentistry. Thus, this study evaluates the need for a PM course in an undergraduate (UG) dental program.
Knowledge and awareness of forensic dentistry course among undergraduates
Authors: Shree M. Kavya , Jeevanandan Ganesh , Govindaraju Lavanya
Published: May 2024

Forensic odontology is an expanding field within the domain of forensic sciences, where dental knowledge is applied in identification of individuals through analysis of the dental-related records. The study goal was to determine if undergraduate students were aware of the forensic dentistry course. A cross-sectional survey was initiated about the need for forensic courses in UG program. Nearly 100 students participated in this survey, data have been collected, and graph has been plotted. Data have been collected with the help of SPSS software; data have been analyzed and plotted as graph. One hundred students responded the survey; only limited people's opinions have been collected. The result varies among the students; 58% knows about the importance of forensic odontology in dentistry using Chi-square value, P = 0.09. The majority of students, who replied to this poll, had some understanding and awareness of forensic odontology in dentistry, but they need to learn more about how it is practiced.
Comparative analysis of weld strength of nickel-chromium and cobalt-chromium base metal alloys when submitted to tungsten inert gas welding
Authors: Shenoy Amrutha , Ahmed Nabeel , Rajaraman Vaishnavi , Maiti Subhabrata , Ganapathy Dhanraj M.
Published: May 2024

Long span base metal alloy fixed prosthesis and partial dental prosthesis frameworks most often require welding for better fit and adaptation. The type of metal alloys used and its effect on the weld strength of the prosthesis have to be investigated. The aim of the study is to comparatively analyze the weld strength of nickel-chromium (Ni-Cr) and cobalt-chromium (Co-Cr) base metal alloys when subjected to tungsten inert gas (TIG) welding. 10 nickel- and cobalt-based specimens were obtained by casting of castable resin patterns of dimension 25 mm × 3 mm × 1 mm. Welding of the samples was carried out using the Lampert PuK 2 welding equipment, and a three-point bend test using a universal testing machine was carried out to evaluate the weld strength of the specimens. Statistical analysis was carried out using the SPSS software version 23. Higher weld strength was observed in the Co-Cr alloy (mean = 898 MPa) than in the Ni-Cr alloy (mean = 690 MPa), when submitted to TIG welding (P < 0.05). TIG welding could be a better alternative for joining base metal alloys for long span edentulous cases, and cobalt-based alloys could be better alternatives to nickel-based alloys that usually tend to cause hypersensitivity reactions.
A cross-sectional study on assessing depression among hemodialysis patients
Authors: Albuhayri Aeshah Hamed , Alshaman Areej Rabea , Alanazi May Naif , Aljuaid Ruwaa Muteb , Albalawi Reem Ibrahem Mobark , Albalawi Shouq Salem , Alsharif Mohammed Omar , Alharthi Nouf M. , Prabahar Kousalya
Published: May 2024

Depression is the most common disorder of psychiatric illness experienced by hemodialysis patients. Failure to measure depression may diminish their well-being. The main objective of this study is to assess depression in hemodialysis patients. The primary goal is to find out the prevalence of depression among chronic kidney disease (CKD) patients. The secondary goal is to find the association between age, sex, and the severity of depression among patients with CKD. This cross-sectional study was performed at the Nephrology Department of King Fahad Hospital, Tabuk, from December 2021 to April 2022. Depression was assessed using a validated Arabic version of the Zung Self-Rating Depression Scale, which is a self-administered questionnaire to assess depression. The mean age of subjects was 42.13 years (standard deviation = 15.65), most of them were in the age group of 18–29 and 40–49 years (n = 59, 24.58%), and the majority were male (n = 128, 53.33%). The depression prevalence among hemodialysis patients was 74.58%. Majority of the patients were with mild depression (n = 175, 72.92%). No significant difference was found for depression among different age groups or genders with ongoing hemodialysis, in our study. Even though the prevalence of depression was high, mostly they were in the mild category. Depression should be assessed frequently, and psychological counseling should be given to improve the well-being of patients.
Awareness on resonance frequency analysis in dental implantology among dental practitioners and dental students
Authors: Sharma M. Neha , Ahmed Nabeel , Ganapathy Dhanraj M. , Pandurangan Kiran Kumar , Maiti Subhabrata
Published: May 2024

In a partial or entirely independent jaw, oral implantology is a technique in dentistry used to enhance the function of mastication, esthetics, and phonation. An important diagnostic aspect for the effectiveness of implant therapy is the stability of the implants. This study aims to measure dental professionals' and dental students' knowledge of resonance frequency analysis (RFA) in dental implantology. This study aims to measure dental professionals' and dental students' knowledge of RFA in dental implantology. One hundred ninety-nine dentists and dental students participated in an online survey study that was delivered through Google Forms. For statistical analysis, tabulated data from the Excel sheets were transferred into the SPSS program. The Chi-square test is also used to examine clinical relevance. According to the study's findings, 60% of the respondents were male and 46% of those who responded were dental professionals. The respondents were primarily between the ages of 18 and 22 (36%). The majority of dental undergraduates and graduates were found to be knowledgeable about the various techniques used to gauge implant stability (P = 0.04 < 0.05). Within the limitations of this study, it was found that most of the dental students and dental practitioners participating in this study were aware of implant stability. The majority of the respondents were aware that RFA was used to measure primary and secondary stability and osseointegration.
Antimicrobial study of cast post and its surface modification with nanoparticle
Authors: Pavithra A. S. , Maiti Subhabrata , Rajeshkumar S. , Jessy P.
Published: May 2024

A cast post is a one-piece unit that is custom fabricated for the tooth at the dental laboratory. Traditional extracts such as neem and green tea have good antimicrobial and antioxidant activity against pathogens. The empty canal space may provide a suitable environment for promoting bacterial growth. The main aim of the study is to find the antimicrobial activity of the cast post coated with the nanoparticle. Prepared cast post was coated with prepared green tea and neem-mediated zinc oxide (ZnO) nanoparticles. Culture is done in agar media where control is noncoated post and another is nanoparticle coated post was implanted in the agar media. The zone of inhibition was noted and statistical analysis was done. The maximum zone of inhibition found on Candida albicans (19.333 2.081) followed by Enterococcus faecalis (14.000 3.605), and Streptococcus mutans (12.666 2.516). Green tea and neem-mediated ZnO nanoparticle showed good antimicrobial activity against the tester microorganism. Cast post coated with nanoparticles has been proved to be important as it is helpful in the prevention of origin and spread of infection around the canal and through the apical foramen.