bluuebunny/crossref_metadata_2025 huggingface dataset:
Positive Low Cloud Feedback Primarily Caused by Increasing Longwave Radiation from the Sea Surface in Two Versions of a Climate Model
Authors: Ogura Tomoo , Webb Mark J , Lock Adrian
Published: October 2023

Low cloud feedback in global warming projections by climate models is
characterized by its positive sign, the mechanism of which is not well
understood. Here we propose that the positive sign is primarily caused
by the increase in upward longwave radiation from the sea surface. We
devise numerical experiments that enable separation of the feedback into
components coming from physically distinct causes. Results of these
experiments with a climate model indicate that increases in upward
longwave radiation from the sea surface cause warming and absolute
drying in the boundary layer, leading to the positive low cloud
feedback. The absolute drying results from decrease in surface
evaporation, and also from decrease in inversion strength which enhances
vertical mixing of drier free tropospheric air into the boundary layer.
This mechanism is different from previously proposed understanding that
positive low cloud feedback is caused by increases in surface
evaporation or vertical moisture contrast.
Automated parameterization of stomatal conductance models from thermal imagery by leveraging synthetic images generated from Helios 3D biophysical model simulations
Authors: Mayanja Ismael , Yun Heesup , Earles Mason , Bailey Brian N.
Published: October 2023

Stomatal conductance (g ) is a critical
plant biophysical variable that reflects plant regulation of
CO uptake and associated water loss, yet its direct
measurement is often prohibitively time-consuming. Estimating the
impacts of g indirectly through leaf
temperature (T ) is a common practice,
but is complicated by confounding factors such as ambient conditions,
measurement aggregation scale, sample size, and measurement time.
Using T measurements to instead
determine parameters of a model for g
that can remove these external factors can provide quasi-traits that are
more reliable and heritable. Our objective was to develop an automated
pipeline for g model parameterization
using thermal data, which could be applied within a 3D biophysical model
to predict the impacts of trait variation on canopy-level processes
related to water-use efficiency. Field experiments were conducted on
common bean, cowpea, and sorghum crops, involving high-resolution
thermal measurements obtained from a robotic sensing platform.
Subsequently, a deep learning algorithm was trained using synthetic
thermography data generated using Helios 3D model simulations
encompassing canopy structure, ambient conditions, and
T , enabling the prediction of
long-wave radiation and incident shortwave radiation for each thermal
image pixel. Following this, a leaf-surface energy budget analysis was
applied to the collected field thermal data to predict
g parameters. Validation of these
predictions was performed through comparisons with ground-truth
leaf-level gas exchange data. This pipeline offers a promising pathway
to predictive simulations of water status and transpiration-related
traits, regardless of environmental variation, ultimately enhancing our
understanding of plant responses to changing environmental conditions.
Importance and competitive advantage of the European Union countries in trade in agri-food products
Authors: Pawlak Karolina
Published: October 2023

The aim of the paper was to show the importance and competitive advantage of the EU countries in trade in agri-food products. It was proved that old member states of the EU, especially Holland, Germany and France, play a dominant role in the agri-food trade. Although agri-food products occupy an important position in the total trade structure of the Central and East European countries, their significance in the exchange of agri-food products in the Community is incomparably smaller.
Vellus-to-terminal Hair Follicle Reconversion Occurs in Male Pattern Balding and is Promoted by Minoxidil and Platelet-rich Plasma: In Vivo Evidence from a New Humanized Mouse Model of Androgenetic Alopecia
Authors: Gilhar Amos , Keren Aviad , Paus Ralf
Published: October 2023

Abstract is missing (Short communication)
A 10-year-old Girl with a Melon Seed-like Nail on her Index Finger: A Quiz
Authors: Wu Zhe , Wu Chenglong , Zhou Kaili , Qian Qiufang
Published: October 2023

Abstract is missing (Quiz)
Jurnal Riset dan Inovasi Peternakan
Authors: Adhianto Kusuma
Published: October 2023

Jurnal Riset dan Inovasi Peternakan(Journal of Research and Innovation of Animals)

Chief EditorKusuma Adhianto

Associate EditorDian SeptinovaRatna ErmawatiFitria Tsani FardaEtha ‘Azizah Hasiib

Editorial BoardRudy SutrisnaFarida FathulAli HusniErwantoRr. RiyantiSyahrio TantaloKhaira NovaSri SuharyatiPurnama Edy Santosa SiswantoLimanTeguh Rafian
NILAI KECERNAAN BAHAN KERING (KcBK) DAN KECERNAAN BAHAN ORGANIK (KcBO) SECARA IN VITRO KLOBOT JAGUNG DENGAN PENGOLAHAN KIMIA DAN BIOLOGI
Authors: Anisa Dahlia Mafida Nur , Liman Liman , Farda Fitria Tsani , Sutrisna Rudy
Published: October 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pengolahan amoniasi klobot jagung terhadap kecernaan bahan kering (KcBK) dan kecernaan bahan organik (KcBO) secara in vitro; mengetahui pengaruh fermentasi klobot jagung terhadap kecernaan bahan kering (KcBK) dan kecernaan bahan organik (KcBO) secara in vitro; mengetahui pengaruh amofer klobot jagung terhadap kecernaan bahan kering (KcBK) dan kecernaan bahan organik (KcBO) secara in vitro. Penelitian ini dilakukan di Laboratorium Nutrisi Perah, Fakultas Peternakan, Institut Pertanian Bogor. Rancangan yang digunakan pada penelitian ini adalah Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dengan 4 ulangan, sehingga berjumlah 16 unit percobaan. Adapun rancangan perlakuan yang digunakan sebagai berikut: P1: Kontrol/klobot jagung tanpa perlakuan; P2: Klobot jagung amoniasi menggunakan 2% urea; P3: Klobot jagung fermentasi menggunakan 5% Aspergillus niger;  P4: Klobot jagung amofer (amoniasi 2% urea + fermentasi 5% Aspergillus niger). Parameter yang diamati adalah kecernaan bahan kering (KcBK) dan kecernaan bahan organik (KcBO) klobot jagung. Hasil penelitian menunjukkan bahwa pengolahan secara kimiawi dan biologi pada klobot jagung tidak memberikan berpengaruh nyata (P>0,05) terhadap KcBK dan KcBO. Kesimpulan dari hasil penelitian ini bahwa uji in-vitro pada perlakuan amoniasi, fermentasi dan amofer tidak berpengaruh nyata (P>0,05) terhadap hasil analisis ragam KcBK dan KcBO; pada hasil analisis ragam KcBK, dan KcBO tertinggi didapat pada perlakuan amoniasi menggunakan urea 2% yaitu 41,58% pada KcBK, dan 47,63% pada KcBO.
PENGARUH LAMA FERMENTASI DAUN NANAS DAN Aspergillus niger TERHADAP KECERNAAN BAHAN KERING DAN BAHAN EKSTRAK TANPA NITROGEN SECARA IN VITRO
Authors: Mukharomah Siti , Fathul Farida , Farda Fitria Tsani , Muhtarudin Muhtarudin
Published: October 2023

Penelitian ini bertujuan untuk mengetahui lama fermentasi dan dosis pemberian Aspergillus niger yang terbaik pada daun nanas terhadap kecernaan bahan kering dan bahan ekstrak tanpa nitrogen secara in vitro. Penelitian ini dilaksanakan pada Januari--Maret 2022 di Laboratorium Nutrisi dan Makanan Ternak, Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung, dan Laboratorium Nutrisi Ternak Perah, Fakultas Peternakan, Institut Pertanian Bogor. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) pola faktorial yang terdiri dari dua faktor. Faktor pertama lama fermentasi (0, 6, dan 12 hari) dan faktor kedua dosis Aspergillus niger (0, 2, dan 4%). Peubah yang diamati adalah kecernaan bahan kering dan kecernaan bahan ekstrak tanpa nitrogen. Data yang diperoleh dianalisis menggunakan analisis ragam dengan taraf nyata 5% dan atau 1% dan dilanjutkan dengan uji Least Significant Difference (LSD). Hasil penelitian didapatkan bahwa lama fermentasi dan dosis pemberian Aspergillus niger pada daun nanas berpengaruh sangat nyata (P<0,01) terhadap kecernaan bahan kering dan bahan ekstrak tanpa nitrogen secara in vitro. Nilai kecernaan bahan kering dan bahan ekstrak tanpa nitrogen terbaik terdapat pada kombinasi lama fermentasi 0 hari dan dosis Aspergillus niger 4%, dengan nilai kecernaan bahan kering 56,09% dan kecernaan bahan ekstrak tanpa nitrogen 50,00%.
PENGARUH PENAMBAHAN LARUTAN DAUN KERSEN TERDAHAP KADAR AIR, KADAR PROTEIN, DAN KADAR LEMAK PADA PROSES PEMBUATAN TELUR ASIN RENDAH SODIUM
Authors: Pratiwi Diah Ayu , Septinova Dian , Sutrisna Rudy , Riyanti Riyanti
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan larutan daun kersen dan tingkat penambahan larutan daun kersen terbaik terhadap nilai kadar air, kadar protein, dan kadar lemak telur asin rendah sodium. Penelitian ini dilaksanakan bulan Februari 2022 di Laboratorium Produksi Ternak, Jurusan Peternakan, Universitas Lampung. Penelitian ini dilakukan menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan (0%, 10%, 20%, dan 30%) dan diulang sebanyak 5 kali.  Setiap perlakuan terdiri dari 7 butir telur ayam ras, sehingga jumlah telur yang digunakan yaitu 140 butir. Peubah yang diamati meliputi kadar air, kadar protein, dan kadar lemak. Data dianalisis menggunakan analisis ragam pada taraf nyata 5%. Hasil penelitian menunjukkan bahwa perlakuan penambahan larutan daun kersen dengan 0%, 10%, 20%, dan 30% tidak berpengaruh nyata (P>0,05) terhadap nilai kadar air, kadar protein, dan kadar lemak. Dapat disimpulkan bahwa penambahan larutan daun kersen dalam proses pembuatan telur asin rendah sodium dapat digunakan sampai tingkat penambahan 20%.
Predictors of Patient’s Survival after a Diagnosis of Cervical Cancer Patients at Moi Teaching and Referral Hospital
Authors: Kiptoo Wilson , Kosgei Mathew Stanley , Kipkosgei Tum Isaac
Published: October 2023

Cervical cancer is one of the most prevalent cancer in women. It is the fourth leading cause of cancer deaths in women worldwide after breast cancer, lung cancer and colorectal cancer. In Kenya, cervical cancer is the leading cause of death in women, and has been shown to have increased by 3 211 in the past 5 years. An increase in cervical cancer in Kenya, has resulted in an economic burden for patients and families. There is an increase in healthcare spending as well as productivity losses due to morbidity and mortality at a productive age. The purpose of the study was to determine the predictors of survival after a diagnosis of cervical cancer. A retrospective cohort design was used in the study. A total of 175 cervical cancer patients were studied over a five-year period, from January 1st to December 31st, 2014. A Cox regression model were used to assess the predictors of survival after cervical cancer diagnosis. The study findings revealed that age, marital status, employment status, family history, smoking status, comorbidity, cancer grade, staging of the disease and treatment plan were factors that increased the risk of death for cervical cancer patients. In conclusion, risk factors affecting the life expectancy of cervical cancer patients include age, marital status, employment status, family history, smoking status, comorbidity, cancer grade, staging of the disease and treatment plan. In an effort for an intervention on factors that increased the risk of death for cervical cancer patients, a collaboration between the Government, private organizations, and local communities is critical. This includes promoting and developing cervical cancer awareness among the public so that women adopt healthy lifestyles and early screening behaviours.
ChatGPT4 on the Color Theory
Authors: Stávek Jiří
Published: October 2023

This is my first attempt to communicate with ChatGPT4 on the color theory. ChatGPT4 reacted promptly with a good overview of this very wide topic. ChatGPT4 during our half hour conversation concluded that there is still a room for the further development of the physical color theory because this research field is far from the final theory. One potential candidate for a more general physical theory can be found in the overlooked works of Old Masters working in the 17th Century.
Actas del I Seminario + Workshop Refotografía y Arquitectura en el Mediterráneo
Authors: Muñoz Jiménez José , Carballeda Camacho Mireya R.
Published: October 2023

Compilación de resúmenes de los conferenciantes del I Seminario Refotografía y Arquitectura en el Mediterráneo, así como de las fotografías realizadas por los participantes en el Workshop sobre el mismo tema, celebrados ambos entre el 30 de septiembre y el 5 de octubre del año 2021. El seminario integra y desarrolla tres líneas de trabajo relacionadas con el hecho de la refotografía. La primera se realiza mediante la incorporación de un tema de suma importancia en estas investigaciones, como es el estudio y puesta en valor del patrimonio fotográfico existente, las colecciones y archivos fotográficos, tan necesarios en la actualidad para la construcción de la identidad y la memoria colectiva de cualquier pueblo, con las tensiones y conflictos propios de estos escenarios. La segunda línea de trabajo se realiza por medio de investigaciones en Arquitectura, y en los que la refotografía es usada como metodología. La tercera y última aproximación pretende, mediante la enseñanza de la metodología refotográfica en titulaciones regladas de diferentes niveles educativos, hacer partícipes del potencial de esta actividad e integrar en ella al diferente alumnado involucrado en nuestras enseñanzas.
Work–Life Balance, Supervisor Support, and Life Satisfaction in the Higher Education Sector
Authors: Wani Ambreen Khursheed
Published: October 2023

The study explores the relationship between work–life balance and supervisor support in the Indian higher education sector. More specifically, the study explores the effects of supervisor support on the work–life balance of female employees working in academia. We used online panel data comprised of 300 employees working in various universities, which we analysed by employing structural equation modelling. Results reveal that supervisor support is positively related to employee work–life balance and ultimately their life satisfaction. The findings also stress the importance of supervisor support for female employees, as its presence is a major boost in helping women reach the desired work–life balance. With the objective to augment work–life balance of women academicians, the work would guide managers as well as decision makers involved in the academic sector to implement women-friendly policies and programmes.
Some aspects of the diagnosis and treatment of eosinophilic granuloma in cats
Authors: Omelchenko Hanna , Avramenko Natalia , Kulynych Serhii , Petrenko Maksym , Volosovets Vladyslav , Volosovets Natalia , Woźniakowski Grzegorz
Published: October 2023

Introduction

Eosinophils represent the most active cells in mammals that show protective and assistive activity in the host immune defence against helminth parasites. These cells are also responsible for the reduction of allergic and inflammatory reactions. The eosinophils play a key role in allergic reactions by secretion of different chemical molecules leading to swelling, lesions and granuloma onset.

Material and Methods

The study was carried out on 30 cats with inflammatory skin lesions. The cats ranged in age from seven months to 13 years, and had an average age of three years. The research methodology included information on the disease, dermatological conclusions, concomitant disorders, medical and laboratory data and the treatment strategy.

Results

In total, 30 cats were diagnosed with eosinophilic granuloma complex. The distribution of lesions was 87.1% in the skin and 12.9% at the skin–mucosal junction. The lesions increased and decreased with the seasons of spring and summer, and the onset of the disease usually coincided with exposure to fleas.

Conclusion

Eosinophilic granuloma complex in cats is a serious pathology and frequently requires lifelong treatment, so it is important to diagnose it quickly and accurately to ensure optimal treatment of affected animals.
Temas recientes del análisis de frecuencias hidrológico
Authors:   Instituto Mexicano de Tecnología del Agua, Campos Aranda Daniel Francisco
Published: October 2023

El libro que ahora publica el IMTA Temas recientes del análisis de frecuencias hidrológico, del Dr. Daniel Francisco Campos Aranda, expone en siete capítulos los avances y enfoques novedosos de las técnicas probabilísticas, desde el transporte de información hidrométrica y sus pruebas estadísticas hasta la aplicación de las funciones Cópula en los análisis multivariados de las credenciales anuales.
STRATEGI MARKETING PUBLIC RELATIONS DALAM MEMPROMOSIKAN BISNIS FASHION MECCANISM DI MASA PANDEMI COVID-19
Authors: Azizah Dewi Nur , Yuningsih Siska
Published: October 2023

Penelitian ini di latar belakang oleh perkembangan fashion di Indonesia yang mengalami peningkatan yang cukup pesat. Pada tahun 2020 muncul wabah penyakit Covid-19. Adanya pandemi Covid-19 ini berdampak pada sektor-sektor yang ada, salah satunya industri fashion. Dalam mempertahankan bisnis fashion di masa pandemi Covid-19, diperlukan strategi-strategi yang tepat dan sesuai. Strategi Marketing Public Relations menjadi penting dalam mempromosikan perusahaan kepada konsumen. Penelitian ini bertujuan untuk mengetahui pull strategy, push strategy, pass strategy yang digunakan Marketing Public Relations Meccanism dalam melakukan promosi di masa pandemi Covid-19, peluang dan hambatan yang dihadapi Marketing Public Relations Meccanism di masa pandemi Covid-19. Penelitian ini menggunakan metode analisis deskriptif dengan pendekatan kualitatif. Adapun teknik pengumpulan data yang digunakan dalam penelitian ini yaitu dengan wawancara, observasi dan dokumentasi. Hasil penelitian ini adalah bahwa pull strategy yang digunakan yaitu publikasi media (website dan media sosial) dan giveaway. Push strategy yang digunakan yaitu kerjasama e-commerce, event dan potongan harga, pass strategy yang digunakan yaitu sponsorship dan charity, peluang yang dihadapi yaitu semakin meningkat nya penggunaan gadget untuk mencari informasi, semakin meningkatnya keinginan masyarakat dalam mengikuti trend fashion saat ini. Hambatan yang dihadapi yaitu kurangnya komunikasi yang baik antar tim.
Competences Associated to Sustainable Leadership Practices: A Study Carried Out in the Public City Administration of Fazenda Rio Grande, State of Paraná
Authors: Daversa Michel Cleiton Andersson , Farias Ariadne
Published: October 2023

Purpose: The purpose of this article is to identify the competences associated to sustainable leadership practices in the public city administration of Fazenda Rio Grande, Paraná.
 
Literature review: The study addresses the concepts of professional competences and sustainable leadership and how they can be applied to the public sector from the perspective of public city administrators.
 
Method: This is a qualitative and exploratory study that was carried out in the City Hall of Fazenda Rio Grande, Paraná. It derived out of the analysis of official documents and semi-structured interviews conducted with eleven public city administrators.
 
Results and conclusion: The study has revealed that the necessary competences for sustainable leadership practices in the public administration of Fazenda Rio Grande, Paraná are: public resource management, strategic planning, focusing on citizens, people management, environmental sustainability orientation, and environmental awareness.
 
Discussion:  The study can provide public administrators with a way to reflect upon their practices, which can positively impact the improvement of their competences and conduct related to the performance of their duties, along with working as a model for public policies characterized by social transformation.
 
Originality/value: Identifying the competences associated with sustainable leadership practices in public administration facilitates reflection about the enhancement or development of attributes that are essential for improving the quality of life and well-being of citizens, along with promoting sustainable territorial development at the local level.
The Effect of Glazing on Full Contour Zirconia - A Systematic Review
Authors: I. Fouad Riyam , E. alwan Al Jorani Lateef , Kareem J. K. Al-Azzawi Abdel
Published: October 2023

To assess the present condition of status of Knowledge on highly translucent Zirconia Materials as well as glazing materials. Materials and methods: enhance the process of glazing on monolithic zirconia, can be used in clinical practice as a replacement for traditional polishing procedure. An electronic sys tematic review was performed in different databases: (Science Direct, PubMed, Web of Science and Google Scholar searches) were consulted on this topic, as well as on a hand search of the scientific literature. Published work from 2003 to 2022 was collected; analyzed and pertinent articles we re selected for inclusion on this review. Studies reported gla zing on monolithic zirconia. Based on their applicability, m ore than sixty-seven papers were selected for this review. Res ults: -The findings strongly suggest that there is potential f or improvement in each of the current materials and proce dures for glazing material on highly translucent Zirconia . The findings indicate that current knowledge is suffici ent to recommend monolithic zirconia for crowns and fixed par tial dentures for routine clinical use.
Occlusal Characteristics of The Primary Dentition in Salah Al-Din City
Authors: K. M. Jamal , J. Falah Khalid , S. Mayuof Faisal
Published: October 2023

Occlusal characteristics that are found in the primary dentition have a substantial role in the occlusal characteristics which will appear in permanent dentition. Consequently, a good background of Occlusal characteristics in children is substantial for dental practitioners. Use an observational, cross-sectional study on selected children randomly in Salah Al-Din to define the occlusal characteristics of primary dentition in the group of Salah Al-Din's children. Objective: Collecting more data and information about the occlusal characteristics of primary dentition in a group of Salah Al-Din's children. Methods: In randomly form selected 413 children between 3 and 6 years old from Salah Al-Din governorate as the sample. Under natural daylight or room light, the examination was done on all children to observe needed characteristics with the inclusion criteria. Prevalence of different types of terminal plane, primary canine relationship, anterior and posterior crossbite overjet, overbite, and primate spaces of the primary dentition were estimated. In the terminal plane we see that the flush terminal plane is the most prevalent type (63.20%). In a primary canine relationship, Class I was the most common type (80.39%). The ideal form of overjet was most common (88.86%). The most common form of overbite was the normal overbite (82.32%). Anterior and posterior have low prevalent (3.63%,1.94% respectively). Observed that primate space was present in 71.19% of the upper arch, and 60.05% is the ratio of mandible space. Conclusion: Most of the sample has desirable occlusal characteristics such as Flush terminal plane, Class 1 canine relationship, normal overjet etc., and undesirable occlusal characteristics have low prevalence as anterior open bite, reverse overjet..etc.
Tratamento de dor radicular da hérnia de disco lombar: microdiscectomia versus abordagens fisioterapêuticas
Authors: Mussi Higor Gomes , Queiroz José Gabriel Vilhena de , Rezende Bárbara Ellen Souza , Caciquinho Igor Bernardes , Silva Jessica Aguilar da , Santos João Pedro Ribeiro , Moreau Lais dos Santos , Pessoa Lucas de Souza Gontijo , Decina Mateus Machado , Cunha Marcelo Viana Rodrigues da
Published: October 2023

Objetivo: Discutir as abordagens cirúrgica e conservadora para tratamento da hérnia de disco lombar, suas indicações e perspectiva de melhores resultados. Revisão bibliográfica: Os tratamentos conservadores incluem a fisioterapia, a partir de técnicas como a terapia manual, decoaptação geral e trações axiais, a acupuntura, o pilates, a tração de extensão lombar e a estimulação elétrica transcutânea, e apresentam resultados satisfatórios como primeira intervenção terapêutica. Por outro lado, o tratamento cirúrgico tem como padrão ouro a microdiscectomia, que potencializa e acelera a remissão dos sintomas em comparação ao tratamento conservador, tem custo reduzido e menores taxas de complicações e de reoperações. Considerações finais: Ao comparar ambas as abordagens, foi identificado que a cirurgia é uma boa opção quando há necessidade de alívio rápido e para tratamento de sintomas debilitantes, mas, a longo prazo, não há superioridade da cirurgia em relação ao tratamento conservador, já que o desfecho é semelhante. Entretanto, os pacientes se sentem mais satisfeitos com o tratamento cirúrgico, que é superior a curto prazo em relação à satisfação com o procedimento e à melhora da incapacidade e da qualidade de vida.
Complicações mais prevalentes no uso de soluções hiperosmolares no manejo da Hipertensão Intracraniana
Authors: Queiroz José Gabriel Vilhena de , Mussi Higor Gomes , Silveira Amanda Irce Carvalho , Lima Gregory Francelino , Rodríguez Igor Sinclair Taveira , Santos João Pedro Ribeiro , Oliveira Lívia Francino , Barbara Lorena Xavier Santa , Cerceau Marina Parizzi Brant , Cunha Marcelo Viana Rodrigues da
Published: October 2023

Objetivo: Comparar as complicações mais prevalentes no uso de soluções hiperosmolares (manitol e solução salinos hipertônicos (SSH)) no manejo da hipertensão intracraniana (HIC). Revisão bibliográfica: A pressão intracraniana (PIC) elevada é um preditor importante da deterioração neurológica e muitos estudos têm comparado a eficácia de terapias hiperosmolares no controle da hipertensão craniana, sendo as mais estudadas a solução salina hipertônica e o manitol. O presente artigo aborda as intercorrências dessas duas soluções durante suas administrações no manejo da HIC, de modo a constatar se uma delas possui menor efeito adverso em relação à outra e se existem situações específicas nas quais o uso de cada uma se adequa melhor. Considerações finais:  Observa-se que, além dos benefícios semelhantes documentados na literatura acerca do uso do manitol e da SSH no manejo da HIC, também se tem as complicações similares como LRA e o efeito rebote. Nesse sentido, o presente estudo visa comparar as intercorrências em comum e as demais com o objetivo de esclarecer uma análise detalhada destes efeitos para escolha do agente e manejo mais eficaz dos pacientes.
Iraqi Hyacinthus orientalis L. Flowers as the Source of Bioactive Compounds Especially Stigmasterol: Identification, Isolation and Characterization
Authors: Shareef Noor M. , Abdul-Jalil Thukaa Z.
Published: October 2023

This research concentrated on the isolation and identification of stigmasterol from cultivated Iraqi Hyacinthus orientalis flowers part, as there are few studies that deal with these plant-specific flowers as e-research shows. Extraction were done for the flowers part of plant, by the soxhlet apparatus using 85% ethanol, followed by fractionation with petroleum ether to obtain the target of this study. Phytochemical screening was done by gas chromatography-mass spectrometry (GC-MS) for petroleum ether fraction qualitative and quantitative estimation and isolation of stigmasterol by reverse phase high-performance liquid chromatography (RP-HPLC), identification of isolated stigmasterol by Fourier transforms infrared (FTIR) spectroscopy, ultraviolet spectroscopy and liquid chromatography-mass spectroscopy (LC-MS). Announcing that the study considered the first to isolate stigmasterol from flowers part of Iraqi H. orientalis.
Comparative Study of Isomalt and Co-processed Isomalt
Authors: S B Sandhan , M P Wagh
Published: October 2023

Objective: The study aims to compare the tableting qualities of isomalt and co-processed isomalt. Methodology: Co-processed isomalt prepared by melt granulation method evaluated for flow property, dilution potential, Kawakita plot, consolidation index, tabletability, Heckel plot and elastic recovery and compared with isomalt. Result and Discussion: The co-processed isomalt demonstrated superior packing ability compared to isomalt and got rearranged in the early compression stage, as per modified Kawakita equation. Co-processed isomalt had 40% dilution potential for paracetamol as compared with 20% for isomalt. Co-processed isomalt showed 40% dilution potential for ascorbic acid, and nimesulide, whereas mefenamic acid and aspirin showed 30% dilution potential. Co-processed isomalt overcomes the lamination and sticking problem of isomalt which has better tabletability.
In-silico Assessment of Potent Immunomodulators from Pimpinella anisum and its Antioxidant Potential
Authors: Kashid Snehal , Suttee Ashish , Kadam Prasad , Kasarla Ramesh
Published: October 2023

New targets, effective substances, and safety in pharmacological models are highlighted by recent drug development. The study’s primary goal is to use an in-silico technique to determine the immunomodulatory potential of phytoconstituents from Pimpinella anisum. Several computer aided tool were utilized for in-silico. autodock vina is major free tool utilized to examine a drug discovery strategy based on the atomic-level screening of small compounds and proteins and protein-ligand interactions. Basic docking phases include ligand position, orientation, and binding affinities. The current methodology includes ligand choice, protein prep, target, ligand optimisation, target active binding site analysis, and binding affinity. SwissADME was used to assess the pharmacokinetic parameters, and Lipinski’s “rules” were used to assess drug similarity. In the current research paper six ligands such as P-anisaldehyde, trans-anethole, cis-anethole, estragole, and linalool were dock against two proteins 1M48 and 1P9M. Molecular docking studies suggest strong binding affinity between -6.9 to -4.2 in case on 1M48 and -6.2 to -4.7 in case of 1P9M. Further antioxidant potential of P. anisum using several solvents was determined. In-vitro antioxidant study and in-silico screening suggested that P. anisum ethanolic extract can be contributed in immunomodulation
Antioxidant Role of Methionine: As an Essential Sulfur-containing Amino Acids
Authors: Alkatib Samera M , Zaki Ahmed M , Ismail May Kh , Alsarraf Raghad Kh
Published: October 2023

Methionine is one of the essential sulfur-containing amino acids that are used in building proteins. In the body, methionine condenses with ATP to form S-adenosylmethionine (SAM), which acts as a methylation donor in various biological pathways. Methionine is characterized by its antioxidant activity and its ability to modify tissue sensitivity against oxidizing agents. Therefore, this study’s aim included using hydrogen peroxide 0.5% in drinking water to induce oxidative stress in the male rats and testing the ability of different concentrations of methionine for protection or prevention the oxidative stress during 10, 20 and 30 days. Forty male rats with the age of 3-4 months and of weights ranging between 300 to 400 gm were divided into 4 groups: Group (1): control group received drinking tap water, group (2): treated with H2O2 0.5% in drinking water, group (3): treated with H2O2 and methionine 0.3%, group (4): treated with H2O2 and methionine 0.6%. The following parameters in the serum were measured: Vit. C, Vit. E, peroxynitrite, albumin, selenium, zinc, and copper. Treatment with 0.3% methionine produced clear effects on the vit C, peroxynitrite, Zn and Cu levels in the serum, while the treatment with 0.6% methionine produced clear effects on the serum vit E, albumin, and Se levels
Vitamin-E TPGS Based Microemulsion: An Approach for Solubility Enhancement of Poorly Water-Soluble Drugs
Authors: Deulkar Vallabh , Panchani Sunitha
Published: October 2023

Poor aqueous solubility is the primary concern for dissolving new drug substances during early development. Several novel solubility enhancement techniques such as particle size reduction, salt formation, making solid dispersion, complex formation, use of cosolvent techniques, use of surfactants, physical and chemical modification, and PH adjustment using buffering agents have been explored extensively to resolve the issue of poor aqueous solubility of drug substances. Drug delivery in micro and nano-sized formulations is one of the ways to improve the solubility of these drug candidates over the physiological pH range. In recent years, combination methods have also been considered an interesting approach where more than one solubility enhancement technique is used. The present review focuses on the feasible approach for improving the solubility by forming Vitamin E TPGS-based suspension in micro or nano form by particle size reduction. Further, by granulation or spray drying techniques, these suspensions converted to a solid dosage form for oral drug delivery for patient compliance are being explore
Cervicovaginal Fetal Fibronectin Levels in Preterm Labor: Just Association or Reliable Screening Biomarker
Authors: Al-Hachami Mazenah H.J , Alrubayae Bushra  J.U
Published: October 2023

Background: Preterm birth (PTB) is a chief reason for neonatal illness and death. Prediction of PTB can prevent complications. The cervico-vaginal fetal fibronectin (fFN) test is a good predictor for preterm labor (PTL) within 7 to 14 days from testing. The levels of fFN are high during the first 16 to 22 weeks of gestation in normal pregnancy before it drops to very low values and rises over again as the gestation reaches term. The current work aimed to assess the association and reliability of cervicovaginal fFN in predicting PTL. Patient and method: The study was cross-sectional that included hundred pregnant (aging from 20–34 years), gestational age ranging (from 24–34 weeks), and presented with abdominal pain. All applicants’ Detailed medical history regarding age, gravidity, and parity were taken from all applicants. Gestational age was calculated through general examination and abdominal and vaginal examination. During speculum vaginal examination, fFN samples were taken from the cervix and were examined for fFN using the quick check for assay. Statistical scrutiny was carried out by SPSS version 17. A p ≤ 0.05 was measured as significant. Result: The mean age was (27.53 ± 4.23), range (of 20–34). Positive fFN results were detected in only (22%) of patients. Around two-thirds of the women end their pregnancy by normal vaginal delivery. Less than half (45.5%) of the included women delivered within one week after presentation, around 1/3rd (31.8%) delivered after the second week, and only 22.2% delivered during the first day of presentation. There was a significant association between pregnancy outcome and fFN results. A majority (90.9%) of patients end with preterm labor during 2 weeks of follow-up were presented with positive fetal fibronectin. The majority (90.9%) of patients end with preterm labor during 2 weeks of follow-up were presented with positive fFN results. There were non-significant variations between means of gestational ages, parity, and gestational age/weeks between those with positive and negative fFN results. Conclusion: Among pregnant women with uterine contraction before advanced cervical dilatation, the presence of cervicovaginal fFN is an associated and reliable screening test in predicting the risk of PTL.
Clopidogrel Responsiveness in Patients Undergoing Percutaneous Coronary Intervention using Multiplate Analyzer: Frequency and Outcomes
Authors: Khadim Murad A. , Farhan Hasan A. , . Muthanna , Al-Quraishi Muthanna H
Published: October 2023

Objectives: Over and under response to dual antiplatelet therapy (DAPT) can lead to bleeding and thrombotic events in patients undergoing coronary stent placement. The present study aimed to assess the platelet response to clopidogrel in patient undergoing percutaneous coronary intervention (PCI) using Multiplate Analyzer. The primary outcome in the present study was the short-term incidence of stent thrombosis and bleeding events. Background: Multiple electrode aggregometry is a rapid and standardized tool to for diagnosis of platelet defects and monitoring response to DAPT. Methods: A hospital-based, prospective study was conducted on 431 patients who underwent PCI from September 2016 to November 2017 and received clopidogrel therapy. The platelet aggregometry was done using a Multiplate analyzer (Dynabyte, Munich, Germany). Patients were followed for 30 days to assess the incidence of stent thrombosis and bleeding. Results: The patients’ mean age was 58 ± 6.7 years. A total of 40% of the patients were diabetic and 7.7% had chronic renal failure. The rate of clopidogrel non-responders was 10.7%, while clopidogrel over-responders were 18.3%. Patients with diabetes and chronic renal failure had significantly lower platelet responsiveness (40.1% with p < 0.05 and 7.7% with p <0.005, respectively). Smoking was significantly associated with platelet over-responsiveness (39.4%, p < 0.001). Patients with low platelet responsiveness to clopidogrel were associated with an increased risk of definite stent thrombosis (p < 0.005), while increasing bleeding risk was significantly associated with over-responsiveness to patients to clopidogrel (p <0.001). Conclusions: Antiplatelet responsiveness showing individual variability with increased risk of stent thrombosis among the cases with no response to the effect of clopidogrel and high risk of bleeding with the over-responsiveness group.
Investigation of Antidiabetic Activity of Isolated Molecule from the Bark of Olax scandens
Authors: F Johnsymary , M Komala
Published: October 2023

Hyperglycemia caused by defects in insulin synthesis and/or activity characterizes diabetes mellitus (DM), which is categorized as a metabolic condition. Some patients may develop side effects or drug interactions when treating these disorders with synthetic drugs. Due to this, there is an increased interest in researching the medical properties of plants and herbal substances while also considering synthetic medications’ interactions and negative effects. To isolate and identify the flavonoid 5-hydroxy-apigenin-7-O-Dglucopyranoside, the bark of Olax scandens was extracted with methanol in a soxhlet system (5HAG). The current study set out to examine 5HAG’s potential ability to treat albino wistar rats with STZ-induced diabetes. The chemical component significantly lowered rats’ blood glucose levels and improved lipid markers. Hepatic enzymes improved significantly, including SGOT, SGPT, ALP, plasma insulin, and total proteins. Overall, this study exposes new avenues for researching how 5HAG reduces blood sugar levels so drastically, but according to the aforementioned study, the flavonoid possesses antidiabetic properties because of its antioxidant activity. In addition, the isolated flavonoid may significantly impact the reduction of blood sugar and its complications by acting as a lead molecule in the identification of novel antidiabetic drug candidates.
The Effect of Selegiline on Reducing Oxidative Stress in Polymorphonuclear Blood Cells (Lymphocytes) Isolated from Patients with Rheumatoid Arthritis
Authors: Chetia Purbajit , Ahmed Abdul B
Published: October 2023

Rheumatoid arthritis (RA) is a persistent condition resulting in an inflammatory response abide by the pathological mechanism of autoimmunity that causes the cartilage, bone, and joint tissues to deteriorate, lowering one’s quality of life in general. Several studies have suggested a significant association between oxidative stress caused by leukocyte-mediated inflammatory responses and the conversion of a substantial amount of oxygen into diverse free radicals, resulting in oxidative harm, including the chronic nature of rheumatoid arthritis. The utilization of DMARDs which are known as biologic and conventional disease-modifying antirheumatic drugs, has exhibited encouraging results. However, it is crucial to prioritize the discovery of novel and efficacious medications for rheumatoid arthritis in order to address the constraints associated with current therapeutic approaches. Selegiline, a synthetic drug primarily employed to manage Parkinson’s disease, predominantly interferes with the MAO-B enzyme, also known as monoamine oxidase. Additionally, it has been demonstrated to possess free radical-neutralizing properties. The goal of this study is to assess the effectiveness of selegiline in reducing oxidative stress indicators in peripheral blood mononuclear lymphocyte cells isolated from individuals diagnosed with RA. Peripheral blood was collected from 20 RA patients in accordance with the American College of Rheumatology standard. Lymphocytes were isolated following incubation with 1.5 μg/mL phorbol myristate acetate (PMA) and treatment with different concentrations (50–200 μg/mL) of selegiline. This study reveals that selegiline in concentrations of 150 and 200 μg/mL was effective enough to alleviate oxidative stress by scavenging free radicals and improving the level of natural defensive enzymes playing as antioxidants. Therefore, it can be concluded that the MAO-B inhibitor selegiline has potential as a non-toxic repurposed medicine for curtailing the pathological effects of oxidative overload during RA, unlocking the opportunity for further investigation into the impact on other inflammatory cells, such as neutrophils.
Evaluation of Antidiabetic Activity of Various Extract of Peristrophe bicalyculata (R.) Nees
Authors: Dwivedi Sumeet , Singh Udita , Patel Prakash C. , Bijwar Rahul S. , Shidhaye Supriya , Patidar Arun
Published: October 2023

In the conventional medical system, India’s population depends on ancient medicine systems like Ayurveda, Homeopathy, Siddha and Unani for the treatment of disease. With such a large population relying on herbal remedies, scientific support for the efficacy of herbal products that have been used for a long time is essential. Diabetes is predicted to become more common worldwide. According to WHO, developing nations will bear the majority of the burden. Peristrophe bicalyculata (R) Nees. belongs to the Acanthaceae family. It is native to Afghanistan, Africa and India. The plant’s flowers are used medicinally to treat various diseases and disorders. The present paper shows the antidiabetic activity of hydro-alcoholic extracts of P. bicalyculata (R) Nees flowers was investigated using an animal model.
Stability Indicating Assay Method Development and Validation of Sitagliptin and Metformin Combination Tablets by Reverse Phase - HPLC
Authors: Rao Gogada V.P , Lingam Meka , Lakshmi Bavisetti , Vadivelu Anantha L , Suryakala Duvvuri
Published: October 2023

Two pharmaceutical compounds were isolated, separated, and confirmed using chromatographic techniques. The method involved utilizing an inertsil phenyl analytical the analytical column has dimensions of 250 mm x 4.0 mm and contains particles with a size of 5 μm. A solution is filled as a buffer, combined with a mobile phase containing a grid. with a pH of 4.0 made from potassium dihydrogen phosphate, orthophosphoric acid and of acetonitrile in a 70:30 ratio 0.8 mL per minute. The column temperature is maintained at 30℃ as part of the setup. The detection of the two drugs is continuously monitored using this setup. A wavelength of 210 nm using a UV detector with injection volume 20 μL. Forced degradation studies are carried out using PDA detector. Peak homogeneity explained as peak purity using lab solution software
Antimicrobial Activity and Cytotoxicity of “Bang Chang” Thai Cultivar Chili Pepper (Capsicum annuum Var. acuminatum)
Authors: Thongkao Kanittada , Thongmuang Pimporn , Sudjaroen Yuttana
Published: October 2023

Capsaicin is found naturally in the Solanaceae family of plants and linked to numerous health advantage. Capsaicin is also responsible for the antimicrobial properties of chili pepper. Thai Capsicum cultivar “Bang Chang chili pepper” (Capsicum annuum var. acuminatum), initially cultivated in Bang Chang subdistrict, Samut Songkhram, Thailand. This study aims to determine bioactive substances such as capsaicin and phenolic content, as well as antimicrobial activity against pathogenic bacteria, Staphylococcus aureus, S. epidermidis, Escherichia coli and Cutibacterium acnes) and yeast, Candida albicans, and cytotoxicity with human skin fibroblast cells. The TPC and capsaicin in the ethanol extract were 2.50 ± 0.13 mg GAE/g and 0.0104 ± 0.0 mg/100 mL, while in the oil extract were 0.0020 ± 0.0 mg/100 mL and 1.05 ± 0.05 mg GAE/g. Antimicrobial of this chili pepper was found in only oil extract that was inhibited against to C. albicans (inhibition zone = 10.68 ± 0.49 mm) There was preferrable when compared to fluconazole ((inhibition zone = 24.65 ± 0.25 mm). Both extracts (0.0001-1.0 mg/mL) had no effect on human fibroblast cells, implying that they are non-toxic. The finding may imply that non-pungent capsicum strains cannot inhibit bacterial growth due to low amount of phenolics and capsaicin contained. Capsicum variety and temperature of extraction were also affected on their property. As a result, oil extract was favored for C. albicans suppression. This pepper extract can be used as an antifungal agent, and a pharmaceutical formulation must be developed.
Simultaneous Estimation of Curcumin and Vitamin E in Bulk and Cosmeceutical Formulation by UV Spectrophotometry
Authors: Borate Shilpa R. , Mundada Atishkumar S.
Published: October 2023

The goal of present study is to validate the developed assay method per International Council for Harmonisation (ICH) Q2R1 recommendations and create a sensitive, reproducible, and practical method for detecting curcumin and Vitamin E in pure and in cosmeceutical formulations. With the creation and validation of a straightforward, accurate, and repeatable UV spectrophotometric method, curcumin and vitamin E in bulk and cosmeceutical formulation may now be determined simultaneously. The need for a new technique to estimate curcumin and vitamin E in a cosmeceutical formulation has become more pressing due to the lack of a well-described UV analytical method for doing so. Q absorption at 231 and 285 nm were used in the calculation. Vitamin E (16–24 μg/mL) and curcumin (8–12 μg/mL) both behave according to Beer-Lambert’s law at the designated wavelengths. The recovery experiments verified the method’s adherence to ICH standards for accuracy, precision, and resilience. The method under consideration can be employed to accurately determine the quantities of vitamin E and curcumin present in a cosmeceutical formulation
Removal of Cr (III) by using Chitosan-Grafting-Poly(Acryl Acid-Crotonic Acid) Characterization and Kinetic Study
Authors: Mohammed Rasha A , Walli Hazim A
Published: October 2023

Hydrogel nanocomposites were prepared using free radical polymerization chitosan and acrylic acid (AA) in combination with crotonic acid. KPS was employed as the initiating agent, while MBA functioned as the cross-linking agent. The nanocomposite of Ch-g-P(AA-co-CA) is a powerful pollutant absorber. Cr (III) was removed from the water using the combination. Field emission scanning electron microscopy (FESEM) and infrared spectroscopy (FTIR) were used to examine the nanocomposites’ structure and morphology. The kinetics of Cr (III) adsorption was studied using these rates. Pseudo-second order kinetics characterize the adsorption process. Hydrogel nanocomposite efficiently removes Cr by adsorption (III).
Hypolipidemic Activity of a Polyherbal Formulation in Triton WR-1339 and High Fat Diet-induced Hyperlipidemic Rats
Authors: Lad Vishal , Ahmad Sufiyan
Published: October 2023

In hyperlipidemic wistar albino rat models produced by triton and diet, the efficacy of polyherbal formulations containing four different plants was assessed. Rats exposed to Triton WR 1339 had their blood cholesterol and triglyceride levels raised. However, this was reversed when the rats were given syrup or a comparable formulation. Both formulations better lipid outlines in rats with high-fat diet-induced hyperlipidemia. Effects were marginally better with the usual medication Atrovastatin. Liver sinusoidal capillary dilations, cytoplasmic fatty infiltration, and granular degeneration were considerably reduced in polyherbal formulation-treated group II animals related with other groups. As per results, polyherbal formulations in dyslipidaemic circumstances reduce lipid levels by blocking the production of cholesterol and reducing lipid utilization.