bluuebunny/crossref_metadata_2025 huggingface dataset:
Tendência da mortalidade infantil no município de Rio Branco, AC, 1999 a 2015
Authors: Ramalho Alanderson Alves , Andrade Andréia Moreira de , Martins Fernanda Andrade , Koifman Rosalina Jorge
Published: April 2018

OBJETIVO: Analisar a tendência da mortalidade infantil em Rio Branco, AC, de 1999 a 2015. MÉTODOS: Estudo observacional ecológico de série temporal, em que foram utilizados dados de óbitos do Sistema de Informações sobre Mortalidade e Nascimentos do Sistema de Informações sobre Nascidos Vivos. Estimou-se a variação percentual anual por meio do software Joinpoint. RESULTADOS: A taxa de mortalidade infantil reduziu de 26,99, em 1999, para 14,50, em 2015, por 1.000 nascidos vivos, com variação percentual anual de -4,37 (IC95% -5,4– -3,4). Quando estratificada por componentes etários, o neonatal apresentou variação percentual anual de -4,73 (IC95% -5,7– -3,7), e o pós-neonatal de -3,7 (IC95% -5,4– -2,0). A evitabilidade, as causas evitáveis e as causas mal definidas apresentaram tendência descendente em todo o período e as causas não claramente evitáveis apresentaram tendência ascendente até 2008. O grupo de causas que mais contribuiu para os óbitos infantis no período estudado foi o das afecções perinatais, seguido pelo das malformações, das doenças infecciosas e parasitárias, e do grupo das doenças respiratórias. CONCLUSÕES: Apesar da tendência decrescente da taxa de mortalidade infantil na capital, quando comparada à de países desenvolvidos, mostra-se relativamente elevada.
Individual and contextual factors associated to the self-perception of oral health in Brazilian adults
Authors: Silva Janmille Valdivino da , Oliveira Angelo Giuseppe Roncalli da Costa
Published: April 2018

OBJECTIVE: To analyze how individual characteristics and the social context, together, are associated with self-perception of the oral health. METHODS: A multilevel cross-sectional study with data from the Brazilian National Health Survey 2013, the United Nations Development Program, and the National Registry of Health Establishments. The explanatory variables for the “oral health perception” outcome were grouped, according to the study framework, into biological characteristics (sex, color, age), proximal social determinants (literacy, household crowding, and socioeconomic stratification), and distal (years of schooling expectancy at age 18, GINI, Human Development Index, and per capita income). The described analysis was performed, along with bivariate Poisson analysis and multilevel Poisson analysis for the construction of the explanatory model of oral health perception. All analyzes considered the sample weights. RESULTS: Both the biological characteristics and the proximal and distal social determinants were associated with the perception of oral health in the bivariate analysis. A higher prevalence of bad oral health was associated to lower years of schooling expectancy (PR = 1.31), lower per capita income (PR = 1.45), higher income concentration (PR = 1.41), and worse human development (PR = 1.45). Inversely, oral health services in both primary and secondary care were negatively associated with oral health perception. All the biological and individual social characteristics, except reading and writing, made up the final explanatory model along with the distal social determinants of the Human Development Index and coverage of basic care in the multilevel analysis. CONCLUSIONS: Biological factors, individual and contextual social determinants were associate synergistically with the population’s perception of oral health. It is necessary to improve individual living conditions and the implementation of public social policies to improve the oral health of the population.
Associação entre raça/cor da pele e parto prematuro: revisão sistemática com meta-análise
Authors: Oliveira Kelly Albuquerque de , Araújo Edna Maria de , Oliveira Keyte Albuquerque de , Casotti Cesar Augusto , Silva Carlos Alberto Lima da , Santos Djanilson Barbosa dos
Published: April 2018

OBJETIVO: Analisar a associação entre raça/cor da pele e a ocorrência da prematuridade. MÉTODOS: Meta-análise com estudos observacionais, selecionados por revisão sistemática em bases de dados bibliográficos Medline e Biblioteca Virtual da Saúde com os descritores: “Race or ethnic group” e “ethnicity and health” associados às palavras “infant premature” e “obstetric labor premature”. Foram incluídos os artigos publicados no período de 2010 a 2014, do tipo epidemiológico observacional, nas línguas portuguesa, inglesa e espanhola. Foram excluídos os artigos que não possuíam resumos ou que fossem artigos de revisão, teses, dissertações e editorias. Foi adotado o risco relativo e seus respectivos intervalos de confiança (IC95%) como medidas de efeito, obtidos por meio do modelo de efeito aleatório e representados a partir do gráfico do tipo forest plot. Para analisar os possíveis vieses de publicação e qualidade dos estudos, foi utilizado o teste de Egger e a escala de Newcastle-Ottawa, respectivamente. RESULTADOS: Dos 926 artigos identificados, 17 foram elegíveis para o estudo. Dos 17 textos completos publicados, sete eram estudos de coorte retrospectiva, nove eram transversais e um era caso-controle. Com exceção de um estudo, os demais relataram associação positiva entre a raça/cor da pele e a prematuridade. Comparado com recém-nascidos a termo, o risco relativo do efeito combinado naqueles que nasceram prematuros foi de 1,51 (IC95% 1,39–1,69). O gráfico de funil sugeriu viés de publicação. CONCLUSÕES: A presente meta-análise indicou uma associação positiva para o risco da prematuridade segundo a raça/cor da pele.
Routine Assessment and Promotion of Physical Activity in Healthcare Settings: A Scientific Statement From the American Heart Association
Authors: Lobelo Felipe , Rohm Young Deborah , Sallis Robert , Garber Michael D. , Billinger Sandra A. , Duperly John , Hutber Adrian , Pate Russell R. , Thomas Randal J. , Widlansky Michael E. , McConnell Michael V. , Joy Elizabeth A.
Published: April 2018

Physical inactivity is one of the most prevalent major health risk factors, with 8 in 10 US adults not meeting aerobic and muscle-strengthening guidelines, and is associated with a high burden of cardiovascular disease. Improving and maintaining recommended levels of physical activity leads to reductions in metabolic, hemodynamic, functional, body composition, and epigenetic risk factors for noncommunicable chronic diseases. Physical activity also has a significant role, in many cases comparable or superior to drug interventions, in the prevention and management of >40 conditions such as diabetes mellitus, cancer, cardiovascular disease, obesity, depression, Alzheimer disease, and arthritis. Whereas most of the modifiable cardiovascular disease risk factors included in the American Heart Association’s My Life Check - Life’s Simple 7 are evaluated routinely in clinical practice (glucose and lipid profiles, blood pressure, obesity, and smoking), physical activity is typically not assessed. The purpose of this statement is to provide a comprehensive review of the evidence on the feasibility, validity, and effectiveness of assessing and promoting physical activity in healthcare settings for adult patients. It also adds concrete recommendations for healthcare systems, clinical and community care providers, fitness professionals, the technology industry, and other stakeholders in order to catalyze increased adoption of physical activity assessment and promotion in healthcare settings and to contribute to meeting the American Heart Association’s 2020 Impact Goals.
Novel Measure of Local Impedance Predicts Catheter–Tissue Contact and Lesion Formation
Authors: Sulkin Matthew S. , Laughner Jacob I. , Hilbert Sebastian , Kapa Suraj , Kosiuk Jedrzej , Younan Paul , Romero Iñaki , Shuros Allan , Hamann Jason J. , Hindricks Gerhard , Bollmann Andreas
Published: April 2018

Background:

Coupling between the ablation catheter and myocardium is critical to resistively heat tissue with radiofrequency ablation. The objective of this study was to evaluate whether a novel local impedance (LI) measurement on an ablation catheter identifies catheter–tissue coupling and is predictive of lesion formation.

Methods and Results:

LI was studied in explanted hearts (n=10 swine) and in vivo (n=10; 50–70 kg swine) using an investigational electroanatomic mapping system that measures impedance from an ablation catheter with mini-electrodes incorporated in the distal electrode (Rhythmia and IntellaNav MiFi OI, Boston Scientific). Explanted tissue was placed in a warmed (37 °C) saline bath mounted on a scale, and LI was measured 15 mm away from tissue to 5 mm of catheter–tissue compression at multiple catheter angles. Lesions were created with 31 and 50 W for 5 to 45 seconds (n=90). During in vivo evaluation of LI, measurements of myocardium (n=90) and blood pool (n=30) were guided by intracardiac ultrasound while operators were blinded to LI data. Lesions were created with 31 and 50 W for 45 seconds in the ventricles (n=72). LI of myocardium (119.7 Ω) was significantly greater than that of blood pool (67.6 Ω;
P
<0.01). Models that incorporate LI drop (ΔLI) to predict lesion size had better performance than models that incorporate force-time integral (
R
2
=0.75 versus
R
2
=0.54) and generator impedance drop (
R
2
=0.82 versus
R
2
=0.58). Steam pops displayed a significantly higher starting LI and larger ΔLI compared with successful radiofrequency applications (
P
<0.01).

Conclusions:

LI recorded from miniature electrodes provides a valuable measure of catheter–tissue coupling, and ΔLI is predictive of lesion formation during radiofrequency ablation.
Timing of Postdischarge Follow‐Up and Medication Adherence Among Patients With Heart Failure
Authors: Chang Leslie L. , Xu Haolin , DeVore Adam D. , Matsouaka Roland A. , Yancy Clyde W. , Fonarow Gregg C. , Allen Larry A. , Hernandez Adrian F.
Published: April 2018

Background

Medication adherence improves outcomes for patients with heart failure, but adherence rates remain low. We examined the association between earlier postdischarge follow‐up and medication adherence.

Methods and Results

We performed a retrospective cohort study of patients ≥65 years who were hospitalized for heart failure, covered by Medicare Part D, and discharged alive from April 2006 to October 2012 using the Get With The Guidelines‐Heart Failure Registry linked to Medicare claims. Patients were categorized into 4 groups by timing of first postdischarge follow‐up visit: ≤1, 1 to 2, 2 to 6, and >6 weeks. Medication adherence was defined by proportion of days covered of >80% at 90 days and 1‐year posthospital discharge to 5 guideline‐directed medical therapies (angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker, evidence‐based β‐blocker, aldosterone antagonist, hydralazine/isosorbide dinitrate, and anticoagulation for atrial fibrillation). Among 9878 patients with heart failure, 73% had left ventricular ejection fraction ≤40%, median age was 78 years (25th–75th percentile, 71–84), and 48% were male. Overall, 30% had a follow‐up appointment within 1‐week postdischarge and 25% >6 weeks. At 1 year, medication adherence was 53% for evidence‐based β‐blockers, 48% for angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, and 8% for hydralazine/isosorbide dinitrate. We found no significant association between timing of first follow‐up visit and medication adherence at 1 year (1.04, 0.92–1.17) when comparing follow‐up visits >6 weeks to the earliest ones.

Conclusions

Posthospital heart failure discharge, overall adherence to medical therapies in Medicare beneficiaries was low. Early follow‐up was not associated with increased medication adherence to guideline‐directed medical therapy in the short or long term.
Is Transcatheter Aortic Valve Replacement Better Than Surgical Aortic Valve Replacement in Patients With Chronic Obstructive Pulmonary Disease? A Nationwide Inpatient Sample Analysis
Authors: Ando Tomo , Adegbala Oluwole , Akintoye Emmanuel , Ashraf Said , Pahuja Mohit , Briasoulis Alexandros , Takagi Hisato , Grines Cindy L. , Afonso Luis , Schreiber Theodore
Published: April 2018

Background

Chronic obstructive pulmonary disease (
COPD
) patients are at increased risk of respiratory related complications after cardiac surgery. It is unclear whether transcatheter aortic valve replacement (
TAVR
) or surgical aortic valve replacement (
SAVR
) results in favorable outcomes among
COPD
patients.

Methods and Results

Patients were identified from the Nationwide Inpatient Sample database from 2011 to 2014. Patients with age ≥60,
COPD
, and either went transarterial
TAVR
or
SAVR
were included in the analysis. A 1:1 propensity‐matched cohort was created to examine the outcomes. A matched pair of 1210
TAVR
and 1208
SAVR
patients was identified. Respiratory‐related complications such as tracheostomy (0.8% versus 5.8%; odds ratio [
OR
], 0.14;
P
<0.001), acute respiratory failure (16.4% versus 23.7%;
OR
, 0.63;
P
=0.002), reintubation (6.5% versus 10.0%;
OR
, 0.49;
P
<0.001), and pneumonia (4.5% versus 10.1%;
OR
, 0.41;
P
<0.001) were significantly less frequent with
TAVR
versus
SAVR
. Use of noninvasive mechanical ventilation was similar between
TAVR
and
SAVR
(4.1% versus 4.8%;
OR
, 0.84;
P
=0.41). Non‐respiratory‐related complications, such as in‐hospital mortality (3.3% versus 4.2%;
OR
, 0.64;
P
=0.035), bleeding requiring transfusion (9.9% versus 21.7%;
OR
, 0.38;
P
<0.001), acute kidney injury (17.7% versus 25.3%;
OR
, 0.63;
P
<0.001), and acute myocardial infarction (2.4% versus 8.4%;
OR
, 0.19;
P
<0.001), were significantly less frequent with
TAVR
than
SAVR
. Cost ($56 099 versus $63 146;
P
<0.001) and hospital stay (mean, 7.7 versus 13.0 days;
P
<0.001) were also more favorable with
TAVR
than
SAVR
.

Conclusions

TAVR
portended significantly fewer respiratory‐related complications compared with
SAVR
in
COPD
patients.
TAVR
may be a preferable mode of aortic valve replacement in
COPD
patients.
Relationship Between Changes in Fat and Lean Depots Following Weight Loss and Changes in Cardiovascular Disease Risk Markers
Authors: Clifton Peter M.
Published: April 2018

Background

Gluteofemoral fat mass has been associated with improved cardiovascular disease risk factors. It is not clear if loss of this protective fat during weight loss partially negates the effect of loss of visceral fat. The aim of this study was to examine regional fat loss in a large weight‐loss cohort from one center and to determine if fat loss in the leg and total lean tissue loss is harmful.

Methods and Results

We combined the data from 7 of our previously published 3‐month weight‐loss studies and examined the relationship between regional fat and lean tissue loss and changes in cardiovascular disease risk factors in 399 participants. At baseline, leg fat was positively associated with high‐density lipoprotein cholesterol in women and inversely with fasting triglyceride level in both sexes. Abdominal lean tissue was also related to systolic blood pressure in men. Changes in regional fat and lean tissue were positively associated with changes in glucose, insulin, total cholesterol, triglycerides, low‐density lipoprotein cholesterol and systolic and diastolic blood pressure (
r
=0.11–0.22,
P
<0.05) with leg fat and arm lean tissue dominating in multivariate regression. After adjustment for total weight or total fat change, these relationships disappeared except for a positive relationship between arm and lean leg mass loss and changes in triglycerides and systolic blood pressure.

Conclusions

Loss of leg fat and leg lean tissue was directly associated with beneficial changes in cardiovascular disease risk markers. Loss of lean tissue may not have an adverse effect on cardiovascular disease risk, and measures to retain lean tissue during weight loss may not be necessary.
Thrombectomy for M1-Middle Cerebral Artery Occlusion
Authors: Consoli Arturo , Rosi Andrea , Coskun Oguzhan , Nappini Sergio , Di Maria Federico , Renieri Leonardo , Limbucci Nicola , Rodesch Georges , Mangiafico Salvatore , Decroix Jean-Pierre , Kyheng Maeva , Labreuche Julien , Lapergue Bertrand
Published: April 2018

Background and Purpose—

Despite the recent technical evolution of the endovascular treatment of acute ischemic stroke, late and incomplete recanalization can be achieved after several maneuvers but with a potentially higher risk of futile reperfusion and complications, such as clot fragmentation. The aim of this article is to investigate the impact of the angiographic phenotype of M1-middle cerebral artery occlusions, classified as regular and irregular in aspect, on the results of treatment by stent retrievers (SRs) or contact aspiration (CA).

Methods—

From January to April 2016, 84 consecutive patients, admitted for acute ischemic stroke with a middle cerebral artery occlusion, were treated by endovascular therapy. Among them, 60 patients (26M, 34F, median age, 70.5; interquartile range, 58.5–80.0) were treated by SR (25/60, 41.7%) or CA (35/60, 58.3%) as a first-line approach in 2 experienced centers. Patients’ characteristics, timing, and procedural data were prospectively recorded and compared between the 2 study subgroups (regular and irregular phenotype).

Results—

A regular phenotype at the occlusion site was observed in 24 patients (40%). Among these, successful recanalization after the first-line strategy (Thrombolysis in Cerebral Infarction 2b-3) was achieved in 100% of patients treated by CA and in only 33.3% of patients treated by SR (
P
=0.001). For irregular phenotypes, SR achieved Thrombolysis in Cerebral Infarction 2b-3 in 73.9% and CA, in 38.5% (
P
=0.036) of cases. Among regular phenotype patients, the average number of maneuvers was 1.3 (median, 1; range 1–3) with first-line CA and 2.7 (median, 3; range 1–5) with first-line SR (
P
=0.008).

Conclusions—

The angiographic phenotype of the occlusion site may be associated with a different response to SR and CA in this preliminary experience.
Does Solidago litoralis (Asteraceae) merit specific rank? Insights from cytogenetic, molecular and ecological data
Authors: NARDI FLAVIA DOMIZIA , PUSTAHIJA FATIMA , ANDREUCCI ANDREA , CICCARELLI DANIELA , SILJAK-YAKOVLEV SONJA , PERUZZI LORENZO
Published: April 2018

Solidago litoralis (Asteraceae) is a psammophile plant endemic to the northern coasts of Tuscany, Italy. During time, different authors have considered it either as a separate species, subspecies or variety of the European S. virgaurea, but few studies of experimental taxonomy have been investigating the relationship between these two taxa. Aim of this study is to compare S. litoralis and S. virgaurea from different points of view: cytogenetic (karyotype analysis, localization of rDNA loci and genome size estimation), molecular (using two plastidial molecular markers), and ecological (by comparing functional characters). A difference in ecological responses to habitats is confirmed, even though S. virgaurea is potentially capable of assuming ecological strategies similar to those of S. litoralis. Despite this, cytogenetic and molecular analyses failed to reveal any significant difference supporting a specific distinction of S. litoralis. The latter taxon is here hypothesized as being an ecotype at the initial steps of a speciation event, better recognized at subspecific level (S. virgaurea subsp. litoralis).
Species delimitation in the Gehyra nana (Squamata: Gekkonidae) complex: cryptic and divergent morphological evolution in the Australian Monsoonal Tropics, with the description of four new species
Authors: DOUGHTY PAUL , BOURKE GAYLEEN , TEDESCHI LEONARDO G. , PRATT RENAE C. , OLIVER PAUL M. , PALMER RUSSELL A. , MORITZ CRAIG
Published: April 2018

Recent advances in molecular genetic techniques and increased fine scale sampling in the Australian Monsoonal Tropics (AMT) have provided new impetus to reassess species boundaries in the Gehyra nana species complex, a clade of small-bodied, saxicolous geckos which are widely distributed across northern Australia. A recent phylogenomic analysis revealed eight deeply divergent lineages that occur as a series of overlapping distributions across the AMT and which, as a whole, are paraphyletic with four previously described species. Several of these lineages currently included in G. nana are phenotypically distinct, while others are highly conservative morphologically. Here we use an integrated approach to explore species delimitation in this complex. We redefine G. nana as a widespread taxon with complex genetic structure across the Kimberley of Western Australia and Top End of the Northern Territory, including a lineage with mtDNA introgressed from the larger-bodied G. multiporosa. We describe four new species with more restricted distributions within the G. nana complex. The new species are phylogenetically divergent and morphologically diagnosable, and include the relatively cryptic G. paranana sp. nov. from the western Northern Territory, the large-bodied G. pseudopunctata sp. nov. from the southern Kimberley ranges, G. granulum sp. nov., a small-bodied form with granules on the proximal lamellae from the north-west and southern Kimberley ranges and the small-bodied G. pluraporosa sp. nov. restricted to the northern Kimberley. Our revision largely stabilises the taxonomy of the G. nana complex, although further analyses of species limits among the remaining mostly parapatric lineages of G. nana sensu stricto are warranted.
Description of two new pseudocerotids (Rahabditophora: Rhabditophora; Polycladida) from Andaman & Nicobar Islands, India
Authors: DIXIT SUDHANSHU , SIVAPERUMAN C. , RAGHUNATHAN C.
Published: April 2018

The genus Pseudoceros is one of the flashiest among polyclads and is represented by 93 species worldwide while the genus Acanthozoon consists of polyclads with papillae and 14 valid species distributed around the world. Pseudoceros meenae sp. nov. and Acanthozoon fuscobulbosum sp. nov., based on morphological and histological characters have been described in the present paper. Pseudoceros meenae sp. nov. is characterised by white to cream body with three marginal bands; inner black, middle orange and a white rim while and Acanthozoon fuscobulbosum, sp. nov. is characterised by numerous brown and bulbous papillae of variable sizes on dorsum.
Detection of Nitrogen Content in Rubber Leaves Using Near-Infrared (NIR) Spectroscopy with Correlation-Based Successive Projections Algorithm (SPA)
Authors: Tang Rongnian , Chen Xupeng , Li Chuang
Published: April 2018

Near-infrared spectroscopy is an efficient, low-cost technology that has potential as an accurate method in detecting the nitrogen content of natural rubber leaves. Successive projections algorithm (SPA) is a widely used variable selection method for multivariate calibration, which uses projection operations to select a variable subset with minimum multi-collinearity. However, due to the fluctuation of correlation between variables, high collinearity may still exist in non-adjacent variables of subset obtained by basic SPA. Based on analysis to the correlation matrix of the spectra data, this paper proposed a correlation-based SPA (CB-SPA) to apply the successive projections algorithm in regions with consistent correlation. The result shows that CB-SPA can select variable subsets with more valuable variables and less multi-collinearity. Meanwhile, models established by the CB-SPA subset outperform basic SPA subsets in predicting nitrogen content in terms of both cross-validation and external prediction. Moreover, CB-SPA is assured to be more efficient, for the time cost in its selection procedure is one-twelfth that of the basic SPA.
Effects of Non-Driving Related Task Modalities on Takeover Performance in Highly Automated Driving
Authors: Wandtner Bernhard , Schömig Nadja , Schmidt Gerald
Published: April 2018

Objective:

Aim of the study was to evaluate the impact of different non-driving related tasks (NDR tasks) on takeover performance in highly automated driving.

Background:

During highly automated driving, it is allowed to engage in NDR tasks temporarily. However, drivers must be able to take over control when reaching a system limit. There is evidence that the type of NDR task has an impact on takeover performance, but little is known about the specific task characteristics that account for performance decrements.

Method:

Thirty participants drove in a simulator using a highly automated driving system. Each participant faced five critical takeover situations. Based on assumptions of Wickens’s multiple resource theory, stimulus and response modalities of a prototypical NDR task were systematically manipulated. Additionally, in one experimental group, the task was locked out simultaneously with the takeover request.

Results:

Task modalities had significant effects on several measures of takeover performance. A visual-manual texting task degraded performance the most, particularly when performed handheld. In contrast, takeover performance with an auditory-vocal task was comparable to a baseline without any task. Task lockout was associated with faster hands-on-wheel times but not altered brake response times.

Conclusion:

Results showed that NDR task modalities are relevant factors for takeover performance. An NDR task lockout was highly accepted by the drivers and showed moderate benefits for the first takeover reaction.

Application:

Knowledge about the impact of NDR task characteristics is an enabler for adaptive takeover concepts. In addition, it might help regulators to make decisions on allowed NDR tasks during automated driving.
Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss
Authors: Liu M. , Kurimoto P. , Zhang J. , Niu Q.T. , Stolina M. , Dechow P.C. , Feng J.Q. , Hesterman J. , Silva M.D. , Ominsky M.S. , Richards W.G. , Ke H. , Kostenuik P.J.
Published: April 2018

Alveolar bone is a mechanosensitive tissue that provides structural support for teeth. Alveolar bone loss is common with aging, menopause, tooth loss, and periodontitis and can lead to additional tooth loss, reduced denture fixation, and challenges in placing dental implants. The current studies suggest that sclerostin and DKK1, which are established osteocyte-derived inhibitors of bone formation, contribute to alveolar bone loss associated with estrogen ablation and edentulism in rats. Estrogen-deficient ovariectomized rats showed significant mandibular bone loss that was reversed by systemic administration of sclerostin antibody (SAB) alone and in combination with DKK1 antibody (DAB). Osteocytes in the dentate and edentulous rat maxilla expressed Sost (sclerostin) and Dkk1 (DKK1) mRNA, and molar extraction appeared to acutely increase DKK1 expression. In a chronic rat maxillary molar extraction model, systemic SAB administration augmented the volume and height of atrophic alveolar ridges, effects that were enhanced by coadministering DAB. SAB and SAB+DAB also fully reversed bone loss that developed in the opposing mandible as a result of hypo-occlusion. In both treatment studies, alveolar bone augmentation with SAB or SAB+DAB was accompanied by increased bone mass in the postcranial skeleton. Jaw bone biomechanics showed that intact sclerostin-deficient mice exhibited stronger and denser mandibles as compared with wild-type controls. These studies show that sclerostin inhibition, with and without DKK1 coinhibition, augmented alveolar bone volume and architecture in rats with alveolar bone loss. These noninvasive approaches may have utility for the conservative augmentation of alveolar bone.
An Exploratory Study of Organizational Justice and Work Attitudes Among Chinese Prison Staff
Authors: Lambert Eric G. , Liu Jianhong , Jiang Shanhe
Published: April 2018

While both forms of organizational justice are important, the empirical literature indicates that procedural justice generally has wider and greater effects on job attitudes compared with distributive justice. Regression analysis of self-reported survey data from 322 staff at two Chinese prisons in Guangzhou suggests that, while both forms of organizational justice were important for Chinese correctional staff’s organizational commitment, distributive (but not procedural) justice had significant positive associations with both job involvement and job satisfaction. This emphasis on distributive justice differs from what has been empirically found for U.S. correctional staff.
Numerical simulation and analysis of the dynamic finite element model of the fiber motion in the air spinning process
Authors: Han Chenchen , Cheng Longdi , Gao Weidong , Xue Yuan , Xue Wenliang , Yang Ruihua
Published: April 2018

Under the spinning technology of the air-assisted twisting, this paper established the fiber finite element model, which has the structural and dynamic characteristics of the fiber flexible body, based on the space elastic thin rod unit. In this research, we deduced the static equilibrium equation of the fiber finite element model. The nonlinear geometric displacement large deformation problem of the space elastic thin rod unit was treated by the method of stepwise loading successive approximation, and the finite element simulation and analysis of the fiber flexible body’s movement and deformation during the air-jet twisting were carried out and verified by experiment in this paper. This research presents an effective and feasible theoretical model and method for the flexible fiber twisting formation process and mechanism under the high velocity vortex airflow.
Heart rate-reducing therapy with add-on ivabradine and bisoprolol before coronary computed tomographic angiography in a fast-track ambulatory setting
Authors: Muster Viktoria , Wallner Markus , Schmidt Albrecht , Kapl Martin , von Lewinski Friederike , Rainer Peter , Reittner Pia , Tillich Manfred , Brader Peter , Szolar Dieter HM , von Lewinski Dirk
Published: April 2018

Objective

This study was performed to determine whether add-on oral ivabradine in patients treated with beta blockers 1 hour before coronary computed tomographic angiography (CCTA) is effective in lowering the heart rate and thus improving CCTA quality.

Methods

In this single-center cohort study, the data of 294 patients referred for ambulant CCTA were retrospectively screened. Patients with an initial heart rate of ≥75 bpm (n = 112) were pretreated with either a combination of bisoprolol and ivabradine or with bisoprolol alone.

Results

During the scan, there was no difference in heart rate between the two groups Likewise, there was no significant difference in additionally administered intravenous bradycardic agents, the number of motion artifacts, or the radiation dose. Both drug regimens were tolerated well.

Conclusion

Additive oral ivabradine 1 hour before CCTA does not result in a further reduction of the heart rate. Consequently, neither movement artifacts nor radiation dose can be reduced. Therefore, pretreatment with ivabradine does not seem reasonably appropriate in an outpatient clinical setting with short patient contact.
CGRP – a target for acute therapy in migraine: Clinical data
Authors: Messina Roberta , Goadsby Peter J
Published: April 2018

Background

A better understanding of the mechanisms underlying the migraine attack has reinforced the concept that migraine is a complex brain disease, and has paved the way for the development of new migraine specific acute treatments. In recent years, targeting the calcitonin gene-related peptide and its receptors has been one of the most promising pharmacological strategies for both acute and preventive treatment of migraine.

Findings

Randomized double-blind placebo-controlled trials have demonstrated the superiority of small molecule calcitonin gene-related peptide receptor antagonists (gepants) over placebo in treating acute migraine attacks measured as the two-hour pain free endpoint. Gepants also improved migraine associated symptoms, such as nausea, photophobia and phonophobia. Two of the class have had their development stopped because of hepatotoxicity, which is emerging as being due to metabolites. Gepants have a good tolerability and can be safely used in patients with stable cardiovascular disease.

Conclusion

Exciting results have been obtained targeting the calcitonin gene-related peptide pathway to abort acute migraine attacks, thus reinforcing the relevance of mechanism-based treatments specific for migraine.
Assessment of Settlement Profile Caused by Underground Box Structure Installation with an Artificial Neural Network Model
Authors: Park Jun Kyung , Cho Dong Hwan , Hossain Sharif , Oh Jeongho
Published: April 2018

Various empirical equations have been proposed to predict the ground settlement profile caused by the excavation of conventional circular tunnels. However, ground movement for the underground box structure has not been fully studied. In this study, ground settlement induced by underground box installations is investigated using two-dimensional finite element analyses. A new formulation to assess the settlement profile applicable to underground box structure is proposed based on parametric analyses of the changes in ground condition, geometric condition of structure, and construction conditions. This paper also presents a method to predict the maximum surface settlement around an underground box structure with artificial neural networks (ANNs), taking into account nine input variables that have direct physical significance. A MATLAB-based multi-layer back propagation neural network model is developed, trained, and tested with parameters obtained from numerical analyses. The maximum settlement from the ANN model, in conjunction with a new formulation to construct the settlement profile, turns out to be promising, by predicting a settlement profile compatible with field measurement data.
Pedestrian Behavior at Signalized Intersection Crosswalks: Observational Study of Factors Associated with Distracted Walking, Pedestrian Violations, and Walking Speed
Authors: Russo Brendan J. , James Emmanuel , Aguilar Cristopher Y. , Smaglik Edward J.
Published: April 2018

In the past two decades, cell phone and smartphone use in the United States has increased substantially. Although mobile phones provide a convenient way for people to communicate, the distraction caused by the use of these devices has led to unintended traffic safety and operational consequences. Although it is well recognized that distracted driving is extremely dangerous for all road users (including pedestrians), the potential impacts of distracted walking have not been as comprehensively studied. Although practitioners should design facilities with the safety, efficiency, and comfort of pedestrians in mind, it is still important to investigate certain pedestrian behaviors at existing facilities to minimize the risk of pedestrian–vehicle crashes, and to reduce behaviors that may unnecessarily increase delay at signalized intersections. To gain new insights into factors associated with distracted walking, pedestrian violations, and walking speed, 3,038 pedestrians were observed across four signalized intersections in New York and Arizona using high-definition video cameras. The video data were reduced and summarized, and an ordinary least squares (OLS) regression model was estimated to analyze factors affecting walking speeds. In addition, binary logit models were estimated to analyze both pedestrian distraction and pedestrian violations. Ultimately, several site- and pedestrian-specific variables were found to be significantly associated with pedestrian distraction, violation behavior, and walking speeds. The results provide important information for researchers, practitioners, and legislators, and may be useful in planning strategies to reduce or mitigate the impacts of pedestrian behavior that may be considered unsafe or potentially inefficient.
Vitamin D Status among Young Children Aged 6 to 23 Months from 4 Different Ethnic Groups in Yunnan, China
Authors: Li Yanhong , Li Yan , Zhang Xian , Zhao Lin , Chen Liqin , Sun Haisong
Published: April 2018

Objectives:

To determine the prevalence of vitamin D deficiency in 6- to 23-month-old children from 4 different ethnic groups, Han, Lisu, Hani, and Bai, in Yunnan Province of China.

Methods:

A large cohort of 938 young children aged 6 to 23 months who were living in Yunnan, China (23°28′-27°52′ N), were selected and recruited in this study. Venous-blood sampling was conducted in all the participants, and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. The children’s physical status was measured.

Results:

General mean serum 25(OH)D level was 21.46 ± 7.95 ng/mL, which was obtained from a total of 938 cases. No significant difference was found in age, gender, height, and weight of participants from different ethnic groups. The mean 25(OH)D level was significantly lower in children of Lisu ethnic groups compared with that of Han and Hani participants, respectively ( P < .05). In addition, Bai children had lower 25(OH)D content than Hani children ( P < .001). Among the children with 25(OH)D sufficiency, the number of Lisu participants was significantly lower than Han children ( P < .001).

Conclusion:

The prevalence of vitamin D deficiency varied among the ethnically different children in Yunnan, China, and significantly fewer Lisu children maintained vitamin D sufficiency compared with other ethnic children. Recognizing these ethnic differences in treating children with vitamin D deficiency may improve the therapeutic outcome.
Outcomes of Renal Transplants from Spousal Donors: 25 Years of Experience at Our Center
Authors: Gorgulu Numan , Caliskan Yasar , Yelken Berna , Turkmen Aydin
Published: April 2018

Objectives

Many transplantation teams have attempted renal transplants from living unrelated kidney donors, as well as from cadaveric and living related kidney donors. In this study, we evaluated the results for renal transplants from spousal donors at our center.

Methods

We retrospectively analyzed renal transplant patients from spousal donors from 1983 to 2008. A total of 25 patients who underwent a cadaveric donor renal transplant from 1983 to 2008 were also studied as a control group. Patients were evaluated regarding patient and graft survival at 1 and 5 years of follow-up. Acute rejection, delayed graft function, infections, and late complications were recorded.

Results

Thirty-eight male, spousal transplant recipients (group 1), 21 female, spousal transplant recipients (group 2), and 25 cadaveric donor transplant recipients were included this study. Graft survival rates were 96% in group 1 and 100% in group 2 (p=0.76) at 1-year follow-up. Patient survival rates in group 1 and 2 were both 100% at 1-year follow-up. Graft survival rates were 80% in group 1 and 100% in group 2 (p=0.12) at 5-year follow-up. Patient survival rates were 90% in group 1 and 100% in group 2 (p=0.56) at 5-year follow-up. Acute rejection rates were 10% (group 1) and 33% (group 2) (p=0.03); delayed graft function rates were 0% (group 1) and 10% (group 2) (p=0.05); infection rates were 16% (group 1) and 5% (group 2) (p=0.21) as early period posttransplant complications.

Conclusion

Results for transplants between spouses in our groups were comparable to those previously reported in the literature. Acute rejection rates were mildly higher in female recipients than in the male recipients due to pre-sensitization arising from previous pregnancies; however, long-term patient and graft survival rates were not significantly different between female and male recipients.
Biopolymer-based strategies in the design of smart medical devices and artificial organs
Authors: Altomare Lina , Bonetti Lorenzo , Campiglio Chiara E , De Nardo Luigi , Draghi Lorenza , Tana Francesca , Farè Silvia
Published: April 2018

Advances in regenerative medicine and in modern biomedical therapies are fast evolving and set goals causing an upheaval in the field of materials science. This review discusses recent developments involving the use of biopolymers as smart materials, in terms of material properties and stimulus-responsive behavior, in the presence of environmental physico-chemical changes. An overview on the transformations that can be triggered in natural-based polymeric systems (sol–gel transition, polymer relaxation, cross-linking, and swelling) is presented, with specific focus on the benefits these materials can provide in biomedical applications.
Development of multifunctional nanocomposites with 3-D printing additive manufacturing and low graphene loading
Authors: Yamamoto Brennan E , Trimble A Zachary , Minei Brenden , Ghasemi Nejhad Mehrdad N
Published: April 2018

Fused filament fabrication (FFF) or fused deposition modeling is an additive manufacturing (AM) process commonly used for geometric modeling and rapid prototyping of parts called three-dimensional (3-D) printing. Commonly used thermoplastic materials in FFF 3-D printing AM are acrylonitrile butadiene styrene (ABS), polylactic acid (PLA), and polybutylene terephthalate (PBT). However, these materials exhibit relatively low strength and toughness. Therefore, it is desirable to improve various properties of thermoplastics in 3-D printing AM by employing nanotechnology. The combination of 3-D printing and nanotechnology opens new venues for the manufacture of 3-D engineered materials with optimized properties and multifunctionality (e.g. mechanical, electrical, and thermal properties). Hence, in this work, the multifunctional property improvement effects of graphene oxide (GO) on thermoplastic materials suitable for 3-D printing AM are investigated. Low loading of GO with carboxyl and hydroxyl surface functional groups is incorporated into thermoplastic materials suitable for 3-D printing AM by a special mixing technique. ABS is chosen in this study due to its availability. Graphene nanosheets are employed to improve the properties of the developed nanocomposites by 3-D printing AM. GO is chosen to improve the dispersion of graphene nanosheets into the thermoplastic system to increase their interfacial adhesion. A multifunctional property improvement is observed in the developed nanocomposite with less than 0.1 wt% GO. Employing ASTM standard tests, it was found that at a very small loading of 0.06% by weight, GO could improve the properties of the thermoplastic in terms of strength, strain-to-failure, and toughness, while maintaining the stiffness, rendering the developed nanocomposites suitable for various applications of static and dynamic loading. GOs are now commercially available at low prices. At such low loadings, these graphene-type materials become economically feasible components of nanocomposites.
Participatory Management of Irrigation System in North Eastern Region of India
Authors: Devi Chandam Victoria
Published: April 2018

The demand of water by various competing sectors, such as industry, power, drinking and irrigation, is increasing while the supply of available fresh water remains the same. This calls for efficient use of water in all sectors especially irrigation, which consumes the highest amount of water in India. Due to recurrence of drought and flood India suffered from famine, so after the Independence the government has rigorously pursued the construction of irrigation dams to increase agricultural production and meet the increasing demand of food. Construction of dams was given priority than management of irrigation projects. But due to a large gap between irrigation potential created and irrigation potential utilized, there was a paradigm shift in the irrigation sector. As a result, the concept of participatory irrigation management (PIM) was widely spread through seminars, National Water Policies and specific irrigation Command Area Development (CAD) programme. The first National Water Policy in 1987 and the subsequent policies had provisions for involvement of farmers in irrigation management for efficient use of irrigation water. Many states in India implemented PIM Act under the policy. It also applies to the northeastern region (NE region) of India. This region has a traditional irrigation system such as bamboo drip irrigation in Meghalaya, water conservation among the Apatanis of Arunachal Pradesh, zabo system of Nagaland and dong irrigation among the Bodos of Assam which are traditionally managed by the farmers. This article examines the farmers’ participation in irrigation management in the NE region. It attempts to highlight the changes of PIM policies, involvement of farmers or the Water Users’ Associations (WUAs) in irrigation management, constraints and suggest ways to strengthen them for efficient use of irrigation water in the NE region of India.
The Gift of Competence: A Conversation With Michael George
Authors: Teagarden Jim , Zabel Robert , Kaff Marilyn
Published: April 2018

Michael George’s career has focused on children and youth with significant behavior and emotional challenge. His career has spanned experiences as a direct service provider, university professor, and teacher trainer. George has led an effort to provide competent and caring teachers to a population who greatly need such teachers. George shares his thoughts and reflections on a career marked by the call providing the gift of competence.
A Randomized Multicenter Trial Comparing Low-Dose Prednisolone Versus Observation for Prevention of Recurrences in Adult Immune Thrombocytopenia
Authors: Pirunsarn Arunrat , Kijrattanakul Pitiphong , Chamnanchanunt Supat , Polprasert Chantana , Rojnuckarin Ponlapat
Published: April 2018

Adult immune thrombocytopenia (ITP) commonly relapses after stopping treatments. This may be preventable by low-dose steroids. In this multicenter study, adult patients with ITP who had been responding to corticosteroids were randomized with the 2 strata of newly diagnosed and relapsed ITP to prednisolone 7.5 mg/d or observation for 6 months. Relapses were defined by a platelet count below 30 × 109/L and/or clinical bleeding. There were 75 patients evaluable for the efficacy and 77 for safety. The recurrent ITP comprised 57.3%. During the median follow-up of 42 weeks, there were 20.5% (8/39) and 25% (9/36) of recurrences in the prednisolone and control groups ( P = .643), with the hazard ratio (HR) of 0.75 ( P = .549). The significant factor that could predict recurrences was relapsed ITP with the HR of 2.79 (95% confidence interval, 1.02-7.64, P = .037). Prednisolone showed a trend toward a benefit in the relapsed subgroup ( P = .070). Adverse events were not different ( P = .540) and mostly mild. In conclusion, prednisolone maintenance could not prolong relapse-free survival. Relapsed patients deserve further investigations for preventive measures.
Single screw extrusion of apple pomace-enriched blends: Extrudate characteristics and determination of optimum processing conditions
Authors: Singha Poonam , Muthukumarappan Kasiviswanathan
Published: April 2018

Response surface methodology was used to investigate the single screw extrusion of apple pomace–defatted soy flour–corn grits blends and the product properties. Five different blends at a level of 0–20% w/w apple pomace were extrusion cooked with varied barrel and die temperature (100–140℃), screw speed (100–200 rpm), and feed moisture content (14–20% wet basis). Increasing apple pomace content in the blends significantly ( P < 0.05) increased the bulk density, the total phenolic content, and the antioxidant activity of the extrudates. The expansion ratio increased with pomace inclusion level of 5% but decreased significantly ( P < 0.05) at higher levels of pomace inclusion (10–20%). Moisture content had quadratic influence on water absorption and solubility indices. Optimal extrusion cooking conditions most likely to produce apple pomace-enriched extruded snack products were at 140℃ barrel and die temperature, 20% feed moisture content, and 200 rpm screw speed. The results indicated active interaction between apple pomace and starch during expansion process.