bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Diagnostic and Prognostic Predictive Values of Ferroptosis-related Markers in Lung Adenocarcinoma
Authors: Mao Guoliang , Xu Wuqin , Jamil Muhammad , Zhang Wei , Jiao Nanlin , Liu Yinhua
Published: March 2024

Background:

Lung Adenocarcinoma (LUAD), a common and aggressive form of
lung cancer, poses significant treatment challenges due to its low survival rates.

Aim:

To better understand the role of ferroptosis driver genes in LUAD, this study aimed to
explore their diagnostic and prognostic significance, as well as their impact on treatment approaches
and tumor immune function in LUAD.

Methods:

To accomplish the defined goals, a comprehensive methodology incorporating both in
silico and wet lab experiments was employed. A comprehensive analysis was conducted on a
total of 233 ferroptosis driver genes obtained from the FerrDB database. Utilizing various TCGA
databases and the RT-qPCR technique, the expression profiles of 233 genes were examined.
Among them, TP53, KRAS, PTEN, and HRAS were identified as hub genes with significant
differential expression. Notably, TP53, KRAS, and HRAS exhibited substantial up-regulation,
while PTEN demonstrated significant down-regulation at both the mRNA and protein levels in
LUAD samples. The dysregulation of hub genes was further associated with poor overall survival
in LUAD patients. Additionally, targeted bisulfite-sequencing (bisulfite-seq) analysis revealed
aberrant promoter methylation patterns linked to the dysregulation of hub genes.

Result & Discussion:

Furthermore, hub genes were found to participate in diverse oncogenic
pathways, highlighting their involvement in LUAD tumorigenesis. By leveraging the diagnostic
and prognostic potential of ferroptosis driver hub genes (TP53, KRAS, PTEN, and HRAS), significant
advancements can be made in the understanding and management of LUAD pathogenesis.

Conclusion:

Therapeutic targeting of these genes using specific drugs holds great promise for
revolutionizing drug discovery and improving the overall survival of LUAD patients.
A Bird View on the Role of Graphene Oxide Nanosystems in Therapeutic Delivery
Authors: Dhankhar Sanchit , Garg Nitika , Chauhan Samrat , Saini Monika
Published: March 2024

The remarkable physicochemical properties of Graphene oxide (GO), a graphene
derivative, have made it a material with intriguing medical administration potential. Its 2D allotropic
nature is the source of its biological flexibility. The transportation of genes and small
molecules are just two of the many biomedical applications of graphene and its composite. Antibacterial
use in tooth and bone grafts, biofunctionalization of proteins, and treatment of cancer
are among other potential uses. The biocompatibility of the freshly synthesized nanomaterials
opens up a world of potential biological and medicinal uses. Furthermore, GO's versatility
makes it an ideal component for usage in other drug delivery systems, such as hydrogels, nanoparticles,
and micelles. This review aims to compile the existing body of knowledge regarding
the use of GO in drug delivery by delving into its many potential uses, obstacles, and future
developments.
Dopaminergic Drugs and Valproate-associated Refractory Hyponatremia Over Levosulpiride-induced Parkinsonism in an Elderly Female Patient
When Deprescribing was the Only Therapy
Authors: Dehade Amol , Chakrabarti Sankha Shubhra , Reddy Not Taruni Srija , Kaur Upinder
Published: March 2024

Introduction:

Prescribing cascade is a condition in which a drug administered to a
patient causes an adverse reaction that is misinterpreted as a new condition, resulting in the addition
of a new drug.

Case Presentation:

Here, we report the case of an elderly female patient who suffered from
metabolic, neurologic, and urinary consequences of a prescribing cascade of antiemetic, antiepileptic,
and dopaminergic drugs. While levosulpiride caused Parkinsonian symptoms, the dopaminergic
drugs and valproate caused refractory hyponatremia followed by altered sensorium,
and clidinium contributed to urinary retention.

Conclusion:

The case highlights the need to be vigilant for adverse consequences of the prescribing
cascade, especially for antiemetic drugs, such as levosulpiride, because of its propensity
to induce extrapyramidal reactions in older patients. In cases of refractory hyponatremia, a trial
of de-challenge of valproate and dopaminergic drugs should be considered. In addition, the identification
and removal of the culprit drugs can rescue the patient from a disabling cycle of adverse
drug reactions.
An Alternative Concept in Making Hybrid Flow Batteries into Dendrite-Free Full-Flow Batteries
Authors: Weng Guo-Ming
Published: March 2024

:

In this study, the author proposes an alternative concept of using electrostatic force of
cation-exchange resin to attract metal ions and nanoscale conductors onto the polymer matrix to
conduct the electrons for the plating/stripping of the metal species. Due to the even distribution of
the positively-charged functional groups inside the cation-exchange resin, metal formation can
also be well distributed and safety issue caused by metal dendrite can be eliminated. By applying
this transformative concept, various hybrid flow batteries could be “upgraded” to dendrite-free
full-flow batteries. Interestingly, this new concept could also be generalized for all metal-based
aqueous and nonaqueous hybrid systems to upgrade them into next-generation full-flow battery
systems. This work offers an alternative concept to deliver unprecedented battery systems and the
proof-of-concept would be more easily implemented than anticipated.
Phytopharmacological Update on Cannabis sativa (Ganja): A Mini Review
Authors: Varshney Tushar , Sanduja Mohit , Pathak Devender , Sharma Anuj Kumar , Kumari Vibha , Singh Manjul Pratap , Kulshreshtha Mayank
Published: March 2024

:

Cannabis sativa L., a significant herbaceous species in Central Asia, has long been valued for its use in traditional medicine and as a source of textile fiber. This fast-growing plant has recently drawn increased attention because of its many applications. It is an abundant source of wood and cellulosic fibers and a true treasure of phytochemicals. This plant greatly interests the construction and pharmaceutical sectors because its metabolites have potent biological ef-fects on human health. Its inner and outer stem tissues may be used to make concrete-like mate-rials and bioplastics. This study aims to summarize the molecular and scientific knowledge of Cannabis sativa, including its pharmacognostic properties, pharmacological potential, phyto-chemical properties, and prospective future research fields.
Introduction to Computer-Based Simulations and Methodologies in Pharmaceutical Research
Authors: Pal Roy Samaresh
Published: March 2024

Pharmaceutical research is increasingly using computer-based simulations
and approaches to hasten the identification and development of new drugs. These
methods make use of computational tools and models to forecast molecular behavior,
evaluate therapeutic efficacy, and improve drug design. Molecular modeling is a key
application of computer-based simulations in pharmaceutical research. It allows
researchers to build virtual models of molecules and simulate their behavior, which
provides insights into their interactions and properties. Molecular docking is a
computational method used in Computer-Aided Drug Design (CADD) to predict the
binding mode and affinity of a small molecule ligand to a target protein receptor.
Quantitative structure-activity relationship (QSAR) modeling is another pharmaceutical
research tool. QSAR models predict molecular activity based on the chemical structure
and other attributes using statistical methods. This method prioritizes and optimizes
drug candidates for specific medicinal uses, speeding up drug discovery. Another
effective use of computer-based simulations in pharmaceutical research is virtual
screening. It entails lowering the time and expense associated with conventional
experimental screening methods by employing computational tools to screen huge
libraries of chemicals for prospective therapeutic candidates. While computer-based
techniques and simulations have many advantages for pharmaceutical research, they
also demand a lot of processing power and knowledge. Also, they are an addition to
conventional experimental procedures rather than their replacement. As a result, they
frequently work in tandem with experimental techniques to offer a more thorough
understanding of drug behavior and efficacy. Overall, computer-based simulations and
methodologies enable pharmaceutical researchers to gather and analyze data more
efficiently, bringing new medications and therapies to market.
Virtual Tools and Screening Designs for Drug Discovery and New Drug Development
Authors: Dubey Sonal
Published: March 2024

The synergy between virtual tools and screening designs has catalyzed a
transformative shift in drug discovery and new drug development. Leveraging
computational models, molecular simulations, and artificial intelligence, virtual tools
empower researchers to predict molecular interactions, assess binding affinities, and
optimize drug-target interactions. This predictive capacity expedites the identification
and prioritization of promising drug candidates for further investigation.
Simultaneously, screening designs facilitate systematic and high-throughput evaluation
of vast compound libraries against target proteins, enabling the rapid identification of
lead compounds with desired pharmacological activities. Advanced data analysis
techniques, including machine learning, enhance the efficiency and accuracy of hit
identification and optimization processes. The integration of virtual tools and screening
designs presents a holistic approach that accelerates the drug discovery pipeline. By
expounding on rational drug design, these tools guide the development of novel
compounds with enhanced properties. Furthermore, this approach optimizes resource
allocation by spotlighting high-potential candidates and minimizing costly
experimental iterations. As an outcome of this convergence, drug discovery processes
are becoming more precise, efficient, and cost-effective. The resulting drug candidates
exhibit improved efficacy, specificity, and safety profiles. Thus, the amalgamation of
virtual tools and screening designs serves as a potent catalyst for innovation in drug
discovery and new drug development, ensuring the delivery of transformative therapies
to address unmet medical challenges. In this chapter, we shall be discussing different
tools in detail with actual examples leading to successful stories.
Pharmacokinetic and Pharmacodynamic Modeling (PK/PD) in Pharmaceutical Research: Current Research and Advances
Authors: Sood Richa , A. Anita
Published: March 2024

The development of more intricately constructed molecules and drug
delivery systems as a result of technological breakthroughs has increased our
understanding of the complexities of disease and allowed us to identify a wide range of
therapeutic targets. New drug combinations can be designed by correctly using
dynamical systems-based PK/PD models. The unswerving approach that offers a better
knowledge and understanding of therapeutic efficacy and safety is the use of
pharmacokinetic-pharmacodynamic (PK-PD) modeling in drug research. In vivo,
animal testing or in vitro bioassay is used to forecast efficacy and safety in people.
Model-based simulation using primary pharmacodynamic models for direct and
indirect responses is used to elucidate the assumption of a fictitious minimal effective
concentration or threshold in the exposure-response relationship of many medicines. In
this current review, we have abridged the basic PK-PD modeling concepts of drug
delivery and documented how they can be used in current research and development.
Experimental Tools as an “Alternative to Animal Research” in Pharmacology
Authors: Sulakhiya Kunjbihari , Paliwal Rishi , Kisku Anglina , Sahu Madhavi , Aditya Shivam , Soni Pranay , Maru Saurabh
Published: March 2024

Experimental tools have emerged as a promising alternative to animal
research in pharmacology. With growing ethical concerns and regulatory restrictions
surrounding animal experimentation, researchers are increasingly turning towards in
vitro and in silico methods to develop new drugs and evaluate their safety and efficacy.
In vitro tools include cell culture systems, 3D organoid models, and microfluidic
devices replicating complex physiological conditions, such as the blood-brain barrier or
the liver microenvironment. These systems can provide more accurate and predictive
results than animal models, reducing ethical concerns and experimental costs. In silico
methods, such as computer modelling, simulation, and artificial intelligence, enable
researchers to predict the drug-target interactions, toxicity, and pharmacokinetic and
pharmacodynamic properties of new drugs without animal testing. Experimental tools
have several advantages over animal research, including more accurate and predictive
results, lower costs, higher throughput, and reduced ethical concerns. However, the
limitations of these tools must also be acknowledged, such as the inability to fully
replicate the complexity of a living organism, which requires further validation. These
tools offer a promising avenue for advancing pharmacological research while reducing
the reliance on animal experimentation. In conclusion, experimental tools provide an
excellent alternative to animal research in pharmacology to identify and avoid potential
toxicities early in the drug discovery process and have the potential to revolutionize
drug discovery and development. This chapter mainly focuses on the numerous in
vitro, in silico, non-animal in vivo, and emerging experimental tools and their
regulatory perspectives on validation, acceptance, and implementation of the
alternative methods used in pharmacological research.
Computational Tools to Predict Drug Release Kinetics in Solid Oral Dosage Forms
Authors: Shirode Devendra S. , Vaidya Vaibhav R. , Chaudhari Shilpa P.
Published: March 2024

Dissolution is the concentration of a drug that goes into solution per unit of
time under standard conditions of solid-liquid interface, temperature, and composition
of solvent. In the pharmaceutical industry, in vitro dissolution testing has been
established as a preferred method to evaluate the development potential of new APIs
and drug formulations and to select the most appropriate solid form for further
development. Dissolution allows the measurement of some important physical
parameters, like drug diffusion coefficient, and is also used in model fitting on
experimental release data. Kinetic modeling of drug release in dosage forms has served
as a promising alternative to reduce bio studies in the development stage of
pharmaceutical formulations. Qualitative as well as quantitative changes in a
formulation that influence the performance of formulations can be predicted with the
help of different computational tools. The present chapter plans to highlight various
computational tools available online as well as offline such as PCP disso, DD solver,
Kinetds, etc. along with these software, the effective use of Microsoft Office Excel tool
for calculating drug kinetic studies is also discussed here.
The Architecture Heritage of Edirne
Authors: Erdoğan Nevnihal
Published: March 2024

Edirne is a vibrant city of historical importance where civilizations have concentrated throughout the ages, with a unique architectural heritage. Constructions like the Selimiye Mosque from Sinan, the Old Mosque from the fifteenth-century, Üç Şerefeli Mosque, Sultan Beyazid II Mosque, and its many complexes, imarets (public soup kitchens), Dar al-Shifa (medical centers), hans (public inns), baths, bridges, caravanserais, are refined examples of Ottoman-Islamic art.

The Architecture Heritage of Edirne is an exploration of the city's architectural Heritage. approaching the past with a historical perspective through works from all the periods it has endured. Starting with the history of Edirne, the book goes into the details of the historical neighborhood, the central district and the historical architecture in the present day city. The book includes notes on the architecture in each notable district and their respective monuments and sites. This is followed by coverage of the architecture of Edirne's former districts. The book concludes with the author's understanding of Edirne's social and economic fabric, both in the past and present. This chapter details the traditional customs, dances, clothing and economic structure of the city.

The book is a ley reference for scholars and enthusiasts of urban history, architectural heritage and design, fine arts, humanities and social sciences. The breadth of information covered in the book also makes it a resource for anyone interested in Turkish cultural heritage studies.
Marina Warner’s Inventory of A Life Mislaid: An Unreliable Memoir. From Memoir to Filiation Narrative
Authors: Zekri Masson Souhir
Published: March 2024

Marina Warner’s Inventory of a Life Mislaid: An Unreliable Memoir (2021) is her second work belonging to the genre of life writing, more particularly the memoir. She had already written a biography, The Dragon Empress: The Life and Times of Tz’u-Hsi, Empress Dowager of China, 1835-1980, about a Chinese empress in 1972, but her memoir is more personal, rather focused on her parents’ marriage, life itineraries and travels through Italy, England and Egypt during and after WWII. Interestingly, many characteristics of her memoir fit with another life writing genre, identified by the French theorist Dominique Viart in the eighties as the ‘filiation narrative,’ initially in reference to French fiction of the same period. The filiation narrative focuses on a self-reflexive search for parental images, reconstructing the mother’s or father’s life through the excavation of documentation and archives, as well as speculation. This article will attempt to show how such thematic and structural features of the filiation narrative as ‘archeological’ narration, the use of archival documents and objects to restore a parent’s ‘lost’ life and, most importantly, the metabiographical aspect of the ‘enterprise’ are reflected, in various degrees, in Warner’s memoir, making it waver between fiction and non-fiction. These same features may thus pave the way for the English counterpart of the French ‘récit de filiation’ and build a pertinent generic continuity between both memoir and filiation narrative.
SWEEP SİNYALİ PARAMETRE SEÇİMİNDE ÖNERİLEN TEST ATIŞLARI, FARKLI KAYAÇ TÜRLERİ ÜZERİNDE YAPILAN BİR UYGULAMANIN PERSPEKTİFİNDEN VİBROSİSMİK PARAMETRELERİ İÇİN BİR METODOLOJİ
Authors: Aydemir Attila , Karakaş Türker , Bilim Funda
Published: March 2024

Hidrokarbon aramacılığında en çok kullanılan yöntem, sismik yansıma yöntemidir. Bu yöntemde kaynak seçimi oldukça önemlidir. Sismik ekipler tarafından dünyaca en çok tercih edilen kaynak türü ise kontrollü bir kaynak oluşu nedeniyle vibratör olmuştur. Vibratörün yere gönderdiği sinyal “sweep sinyali” olarak adlandırılmaktadır. Bu sinyalin özellikleri, kullanıcı tarafından yeraltındaki tabakaların özelliklerine göre farklı bir parametre ile tanımlanır. Her saha, aynı jeolojik özelliklere sahip olmayacağı için parametre seçimleri de yüzeyin topoğrafik koşulları, yer içinin jeolojik şartları, sinyalin sönümlenme ya da yayılma durumu, hedef derinliğe ulaşması gibi birçok faktöre bağlı olacaktır. Bu nedenle sweep sinyalinin parametre seçimi için yürütülmesi gereken saha test çalışmaları veri toplama aşamasından önce yapılmalıdır. Bu çalışmada, hidrokarbon aranması için vibrosismik yöntem kullanılarak seçilebilecek bütün parametreler irdelenmiş, her bir parametrenin alabileceği değerler ve bunların etkileri tartışılmış olup Güneydoğu Anadolu’da seçilen bir çalışma sahasında örnek bir sweep test parametre çalışmasında en uygun kaynak parametreleri tespit edilmiştir. Böylece, yüzeyde bulunan, özellikle de sismik kalite için bozucu litolojilere sahip formasyonlar üzerinde seçilen parametrelerin gösterdiği farklılıklar ortaya konularak nedenleri tartışılmıştır. Bu çalışmanın önemi, sweep test çalışmalarında dikkate alınması gereken parametreler ve bunların hangi tip litolojilerde, ne gibi sonuçlar verdiğinin gösterilmesi açısından sismik endüstrisinde görev alacak jeofizikçilere referans teşkil etmesi şeklinde açıklanabilir.
Evaluating the Potential and Pitfalls of AI-Powered Conversational Agents as Humanlike Virtual Health Carers in the Remote Management of Noncommunicable Diseases: Scoping Review
Authors: Anisha Sadia Azmin , Sen Arkendu , Bain Chris
Published: March 2024

Background

The rising prevalence of noncommunicable diseases (NCDs) worldwide and the high recent mortality rates (74.4%) associated with them, especially in low- and middle-income countries, is causing a substantial global burden of disease, necessitating innovative and sustainable long-term care solutions.

Objective

This scoping review aims to investigate the impact of artificial intelligence (AI)–based conversational agents (CAs)—including chatbots, voicebots, and anthropomorphic digital avatars—as human-like health caregivers in the remote management of NCDs as well as identify critical areas for future research and provide insights into how these technologies might be used effectively in health care to personalize NCD management strategies.

Methods

A broad literature search was conducted in July 2023 in 6 electronic databases—Ovid MEDLINE, Embase, PsycINFO, PubMed, CINAHL, and Web of Science—using the search terms “conversational agents,” “artificial intelligence,” and “noncommunicable diseases,” including their associated synonyms. We also manually searched gray literature using sources such as ProQuest Central, ResearchGate, ACM Digital Library, and Google Scholar. We included empirical studies published in English from January 2010 to July 2023 focusing solely on health care–oriented applications of CAs used for remote management of NCDs. The narrative synthesis approach was used to collate and summarize the relevant information extracted from the included studies.

Results

The literature search yielded a total of 43 studies that matched the inclusion criteria. Our review unveiled four significant findings: (1) higher user acceptance and compliance with anthropomorphic and avatar-based CAs for remote care; (2) an existing gap in the development of personalized, empathetic, and contextually aware CAs for effective emotional and social interaction with users, along with limited consideration of ethical concerns such as data privacy and patient safety; (3) inadequate evidence of the efficacy of CAs in NCD self-management despite a moderate to high level of optimism among health care professionals regarding CAs’ potential in remote health care; and (4) CAs primarily being used for supporting nonpharmacological interventions such as behavioral or lifestyle modifications and patient education for the self-management of NCDs.

Conclusions

This review makes a unique contribution to the field by not only providing a quantifiable impact analysis but also identifying the areas requiring imminent scholarly attention for the ethical, empathetic, and efficacious implementation of AI in NCD care. This serves as an academic cornerstone for future research in AI-assisted health care for NCD management.

Trial Registration

Open Science Framework; https://doi.org/10.17605/OSF.IO/GU5PX
Mitigating Health-Related Uncertainties During Pregnancy: The Role of Smart Health Monitoring Technologies (Preprint)
Authors: Tretter Max
Published: March 2024

UNSTRUCTURED

Pregnancy is a time filled with uncertainties, which can be challenging and lead to fear or anxiety for expectant parents. Health monitoring technologies that allow monitoring of the vital signs of both the mother and fetus offer a way to address health-related uncertainties. But are smart health monitoring technologies (SHMTs) actually an effective means to reduce uncertainties during pregnancy, or do they have the opposite effect? Using conceptual reasoning and phenomenological approaches grounded in existing literature, this Viewpoint explores the effects of SHMTs on health-related uncertainties during pregnancy. The argument posits that while SHMTs can alleviate some health-related uncertainties, they may also create new ones. This is particularly the case when the abundance of vital data overwhelms pregnant persons, leads to false-positive diagnoses, or raises concerns about the accuracy and analysis of data. Consequently, it is concluded that the use of SHMTs is not a cure-all for overcoming health-related uncertainties during pregnancy. Since the use of such monitoring technologies can introduce new uncertainties, it is important to carefully consider where and for what purpose they are used, use them sparingly, and promote a pragmatic approach to uncertainties.Using conceptual reasoning and phenomenological approaches grounded in existing literature, the effects of SHMTs on health-related uncertainties during pregnancy are explored. The argument posits that while SHMTs can alleviate some health-related uncertainties, they may also create new ones. This is particularly the case when the abundance of vital data overwhelms pregnant persons, leads to false-positive diagnoses, or raises concerns about the accuracy and analysis of data.
Consequently, it is concluded that the use of SHMTs is not a cure-all for overcoming health-related uncertainties during pregnancy. Since the use of such monitoring technologies can introduce new uncertainties, it is important to carefully consider where and for what purpose they are used, use them sparingly, and promote a pragmatic approach to uncertainties.
Performance of ChatGPT on the India Undergraduate Community Medicine Examination: Cross-Sectional Study (Preprint)
Authors: Gandhi Aravind P , Joesph Felista Karen , Rajagopal Vineeth , Aparnavi P , Katkuri Sushma , Dayama Sonal , Satapathy Prakasini , Khatib Mahalaqua Nazli , Gaidhane Shilpa , Zahiruddin Quazi Syed , Behera Ashish
Published: March 2024

BACKGROUND

Medical students may increasingly use large language models (LLMs) in their learning. ChatGPT is an LLM at the forefront of this new development in medical education with the capacity to respond to multidisciplinary questions.

OBJECTIVE

The aim of this study was to evaluate the ability of ChatGPT 3.5 to complete the Indian undergraduate medical examination in the subject of community medicine. We further compared ChatGPT scores with the scores obtained by the students.

METHODS

The study was conducted at a publicly funded medical college in Hyderabad, India. The study was based on the internal assessment examination conducted in January 2023 for students in the Bachelor of Medicine and Bachelor of Surgery Final Year–Part I program; the examination of focus included 40 questions (divided between two papers) from the community medicine subject syllabus. Each paper had three sections with different weightage of marks for each section: section one had two long essay–type questions worth 15 marks each, section two had 8 short essay–type questions worth 5 marks each, and section three had 10 short-answer questions worth 3 marks each. The same questions were administered as prompts to ChatGPT 3.5 and the responses were recorded. Apart from scoring ChatGPT responses, two independent evaluators explored the responses to each question to further analyze their quality with regard to three subdomains: relevancy, coherence, and completeness. Each question was scored in these subdomains on a Likert scale of 1-5. The average of the two evaluators was taken as the subdomain score of the question. The proportion of questions with a score 50% of the maximum score (5) in each subdomain was calculated.

RESULTS

ChatGPT 3.5 scored 72.3% on paper 1 and 61% on paper 2. The mean score of the 94 students was 43% on paper 1 and 45% on paper 2. The responses of ChatGPT 3.5 were also rated to be satisfactorily relevant, coherent, and complete for most of the questions (>80%).

CONCLUSIONS

ChatGPT 3.5 appears to have substantial and sufficient knowledge to understand and answer the Indian medical undergraduate examination in the subject of community medicine. ChatGPT may be introduced to students to enable the self-directed learning of community medicine in pilot mode. However, faculty oversight will be required as ChatGPT is still in the initial stages of development, and thus its potential and reliability of medical content from the Indian context need to be further explored comprehensively.
Recovery and Renewal of Co-Design Approaches in Health: Protocol for a Realist Synthesis (Preprint)
Authors: Mallakin Maryam , Langley Joe , Harvey Gillian , Walker Sarah , Raber Caylee , Beyzaei Nadia , Paczka Giorgi Luz A , Holyoke Paul , Sellen Kate
Published: March 2024

BACKGROUND

The COVID-19 pandemic significantly transformed the landscape of work and collaboration, impacting design research methodologies and techniques. Co-design approaches have been both negatively and positively affected by the pandemic, prompting a need to investigate and understand the extent of these impacts, changes, and adaptations, specifically in the health sector. Despite the challenges that the pandemic imposed on conducting co-design and related projects, it also encouraged a re-evaluation of co-design practices, leading to innovative solutions and techniques. Designers and researchers have explored alternative ways to engage stakeholders and end users, leveraging digital workshops and participatory digital platforms. These adaptations have the potential to enhance inclusivity, allowing for a wider range of individuals to contribute their perspectives and insights through co-design and thus contribute to healthcare change.

OBJECTIVE

This study aims to explore the impacts of the pandemic on co-design and related practices, focusing on co-design practices in healthcare that have been gained, adapted, or enhanced, with a specific focus on issues of equity, diversity, and inclusion.

METHODS

The study uses a realist synthesis methodology to identify and analyze the effects of the pandemic on co-design approaches in health, drawing on a range of sources including first-person experiences, gray literature, and academic literature. A community of practice in co-design in health will be engaged to support this process.

RESULTS

By examining the experiences and insights of professionals, practitioners, and communities who were actively involved in co-design and have navigated the challenges and opportunities of the pandemic, we can gain a deeper understanding of the strategies, tools, and techniques that have facilitated effective co-design during the pandemic, contributing to building resilience and capacity in co-design in health beyond the pandemic.

CONCLUSIONS

By involving community partners, community of practice (research), and design practitioners, we expect closer proximity to practice with capacity building occurring through the realist process, thus enabling rapid adoption and refinement of new techniques or insights that emerge. Ultimately, this research will contribute to the advancement of co-design methodologies and inform the future of co-design in health.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/58318
A Cheap New Geological Dating Method Developed from Ancient Shells Study
Authors: Guiqing Chen , Junhao Chen
Published: March 2024

The vast majority of researchers on ancient shells are biologists, who are not familiar with X-ray diffractometers, etc. We are physical chemists who use X-ray diffraction to observe the changes in the crystal structure of ancient shells? Then use WDX electron probe to observe the changes in the microstructure of ancient shells. After discovering shells for a long time, calcite turned into aragonite, overturning the conclusion recorded in geological crystallographic books that aragonite’s structure and physical properties were unstable and would eventually transform into calcite. Unexpectedly discovered that the “Shuang chen Weathering Cave CC” of ancient shells has changed over time, it can be used as a new method for geological dating.The use of carbon 14 (C14) isotope geological dating method is quite expensive and lacks accuracy, causing many jokes. The “Shuang chen Weathering Cave CC” of ancient shells may be used as a new geological dating method, and it is quite cheap!
Pengaruh Good Corporate Governance Dan Corporate Social Responsibility Terhadap Kinerja Keuangan Perusahaan (Studi Empiris pada Perusahaan Perbankan yang Terdaftar di Bursa Efek Indonesia Tahun 2018-2020)
Authors: Putri Putu Annet Cahaya , Yasa Putu Ngurah Suyatna , Surya Luh Putu Lusi Satyandarini
Published: March 2024

Good Corporate Governance merupakan salah satu sistem dan kebijakan dalam mengatur kinerja keuangan untuk mencapai keberhasilan perusahaan perbankan. Di bantu dengan Corporate Social Responsibility dipergunakan sebagai langkah strategis dalam mengembangkan kinerja keuangan untuk menarik investor. Tujuan daripada dilakukannya penelitian yaitu untuk mencari tahu apakah ada kaitan antara Good Corporate Governance serta Corporate Social Responsibility yang berimplikasi pada kinerja keuangan perusahaan khususnya perbankan. Terdapat sebanyak 43 perusahaan perbankan yang listing di Bursa Efek Indonesia 2018-2020 sehingga disebut populasi dalam penelitian ini. Metode pengambilan sampel yaitu menggunakan sampel dengan kriteria-kriteria tertentu atau sering disebut purposive sampling, yang berjumlah 114 sampel. Sumber data yakni berupa annual report data sekunder diperoleh pada website Bursa Efek Indonesia. Teknik analisis yakni regresi linear berganda. Dengan analisis tersebut bahwa didapatkan hasil kedua variabel bebas signifikan berpengaruh simultan maupun parsial terhadap variabel terikat. Dari hasil tersebut hal ini memiliki makna bahwa semakin banyak jumlah dan adanya keberadaan mekanisme Good Corporate Governance maka kinerja keuangan perusahaan meningkat. Dalam kegiatan Corporate Social Responsibility pun juga demikian semakin banyak pengungkapan indikator daripada kegiatan Corporate Social Responsibility dalam suatu perusahaan maka kinerja keuangannya juga akan membaik dan begitu juga sebaliknya.
PENGARUH GCG, ARUS KAS, LABA TERHADAP FINANCIAL DISTRESS PADA SEKTOR PARIWISATA, HOTEL DAN RESTORAN 2017-2021
Authors: Aryanti Kadek Tarisna , Sutapa I Nyoman , Dewi I Gusti Ayu Ratih Permata
Published: March 2024

Penurunan kunjungan wisman berdampak pada pendapatan, sehingga memungkinkan adanya kondisi financial distress pada perusahaan sektor Pariwisata. Tujuan penelitian untuk menguji dan menganalisis pengaruh kepemilikan institusional, kepemilikan manajerial, dewan direksi, arus kas dan laba terhadap financial distress pada Perusahaan Sub Sektor Pariwisata, Hotel dan Restoran. Metode yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif. Populasi yang digunakan dalam penelitian ini adalah Perusahaan Sub Sektor Pariwisata, Hotel dan Restoran yang terdaftar di BEI periode 2017-2021 berjumlah 35 perusahaan, sampel 18 perusahaan. Jenis data adalah data sekunder. Sumber dari halaman resmi Indonesia Stock Exchange (IDX). Metode pengumpulan data yang digunakan dalam penelitian ini yaitu metode dokumentasi. Metode analisis data yang digunakan dalam penelitian ini adalah Uji Regresi Logistik. Hasil dari penelitian ini menunjukkan bahwa secara parsial kepemilikan institusional tidak berpengaruh secara signifikan terhadap financial distress, kepemilikan manajerial serta dewan direksi berpengaruh signifikan ke arah positif terhadap financial distress, dan arus kas serta laba tidak berpengaruh signifikan terhadap financial distress. Saran yang diberikan peneliti adalah menambahkan variabel profitabilitas, likuiditas, leverage dan sales growth dan faktor non keuangan seperti kurs dan inflasi.
“Defensor das minorias e contra as tiranias” – o Capitão Gay no humor televisivo e entre tentativas de (auto)censura e a cobrança de royalties
Authors: Busetto Áureo
Published: March 2024

Neste artigo são analisadas as possibilidades e os limites relativos à criação e interpretação por Jô Soares do emblemático Capitão Gay. Temática analisada tanto a par da caracterização das linhagens do humorismo televisivo brasileiro e a inserção do humor de Jô Soares nelas. Ademais, são analisados os elementos e recursos televisivos investidos na produção das aventuras do super-herói gay. E, por fim, cuida-se de relações da produção de o Capitão Gay com a direção da Rede Globo de Televisão, moralismos reinantes à época, ocaso da Ditadura Militar, militância gay e universo das marcas registradas.
Circuito Sultan Yaccoub (Líbano) - São Bernardo do Campo (Brasil): Fluxos de uma comunidade muçulmana transnacional
Authors: Da Cruz Rodrigo Ayupe
Published: March 2024

O objetivo deste artigo é analisar a dinâmica das conexões transnacionais entre o vilarejo libanês de Sultan Yaccoub, localizado no Vale do Bekaa, e a comunidade de imigrantes e descendentes estabelecidos em São Bernardo do Campo – SP, cidade que atrai grande parte desses libaneses. A pesquisa foi realizada no ano de 2016 (Sultan Yaccoub) e em 2019 (São Bernardo), a partir do trabalho de campo in loco e da metodologia da História Oral. O resultado desse estudo afirma que essas conexões transnacionais configuram um tipo de circuito imigratório que é sustentado por meio de fluxos humanos, fluxos econômicos e fluxos culturais que se articulam e se movimentam constantemente nas duas direções (Líbano e Brasil) e contribuem para a manutenção de uma comunidade muçulmana transnacional formada por esses imigrantes e descendentes.
Infância e privação social em Santo Antônio do Madeira, 1910-1920
Authors: Barbosa Xênia de Castro
Published: March 2024

Este artigo objetiva contribuir para uma reflexão acerca da história da infância em Santo Antônio do Rio Madeira. De maneira específica, almeja-se discutir as possibilidades de ser dessa infância em face de acirrado quadro de privação social. A aquisição de dados foi procedida mediante pesquisa no Centro de Documentação Histórica do Tribunal de Justiça do Estado de Rondônia, no banco de dados da Biblioteca Nacional, e em obras bibliográficas tangenciais ao assunto. Os resultados apontam para condições sanitárias desfavoráveis, privação social e violência, que se constituíam em empecilho para o pleno desenvolvimento da infância.
Science Communication as a Human Right
Authors: Frías-Villegas Gabriela , García-Gómez Kathia Elisa , Guzmán-Vendrell Alejandro , Mendoza-Hernández Irvin Alberto , Tránsito-Santos Ricardo , Vázquez-Quiroz Fabiola
Published: March 2024

This work discusses four practical science communication cases in which we worked with communities from different parts of Mexico in vulnerable situations. We analyze those cases from an interdisciplinary point of view, emphasizing the observation of human rights to propose a new inclusive definition of science communication and new strategies for engaging in horizontal dialogues with cultural groups. This perspective demands a change in methodological procedures, such as performing anthropological work and the co-creation of projects and materials together with all the members of the communities involved. We also propose using novel strategies to reach communities in vulnerable situations.
Broadening adult engagement and education in science cafés: lessons from an STS — science communication boundary spanning experiment
Authors: Rader Karen A. , Gibbs CJ
Published: March 2024

This essay describes and reflects on a collaboration between a university Science & Technology Studies (STS) educator and a community science café organizer. Our partnership was designed to address two challenges: how to encourage diversity and inclusion in science café audiences and how to create assessments for broader ‘science in society’ content delivered to adult café learners. We used focus groups to develop STS learning constructs and do community engagement needs assessments. We describe the resultant café series development and other outcomes of our cross-domain work in STS, science communication, and science education. We conclude with observations about the power of collaborative storytelling and make general recommendations for how practitioners and scholars can address the described challenges in ways that might ease future collaborations.
Atividades de Educação Ambiental em espaço não formal no contexto de uma formação de professores de Ciências
Authors: Gondin Cristiane Miranda Magalhães , dos Santos Olmedo Alessandra , de Mattos Machado Vera
Published: March 2024

Este artigo apresenta a análise de atividades do Centro de Educação Ambiental Odilza Fernandes Bittar, por meio da observação de visita guiada realizada com professores em Campo Grande-MS, Brasil. Trata-se de uma pesquisa qualitativa pautada na Teoria Antropológica do Didático. Destaca a integração de conhecimentos de Ciências e Educação Ambiental no currículo escolar. O espaço é um recurso valioso para abordar questões socioambientais, contribuindo com a divulgação científica. No entanto, apontou a necessidade de planejamento para ações com escolas, devido à limitação de tempo nas visitas guiadas, o que dificulta a abordagem conforme apontado pelos pressupostos teóricos.
The relationship between satisfaction, engagement, and organizational performance in securities companies
Authors: Nguyen Thi Mo , Cao Minh Tien , Hoang Van Hue , Thuy Linh Vu , Binh Nguyen Thanh , Pham Huy Hung , Tran Anh Thi Lan , Van Hai Tran
Published: March 2024

The stock market is a medium and long-term capital channel for the economy. The stock market only operates effectively when market participants operate effectively. As a core subject, the activities of securities companies have a great influence on the stable and sustainable development of the stock market, as well as on the existence and development of the securities companies themselves. Up to now, research on theoretical and empirical frameworks to clarify the relationship between satisfaction and engagement with performance in securities companies is still limited, especially research on securities companies on the stock market have the goal of upgrading the market from frontier to emerging market like Vietnam. This study proposes solutions to help top managers in Vietnamese securities companies enhance satisfaction, engagement, and organizational effectiveness. The research model was developed based on data collected from 1,250 survey responses from securities companies. By employing quantitative research using partial least squares structural equation modeling (PLS-SEM) in SPSS 20 and SPSS Amos 20 software, the results identified four factors influencing the satisfaction, engagement, and effectiveness of Vietnamese securities companies: 1) reliable and ethically driven top-level management; 2) appropriate job assignments, positions, and core technology systems supporting work; 3) employees’ income significantly affects the company’s effectiveness. Based on the research findings, this paper provides recommendations for securities companies in constructing management policies.
Grenseland - i stemmen
Authors: Berit Norbakken
Published: March 2024

Dette prosjektet er en kunstnerisk utforsking av stemmens klanglige egenskaper, med utgangspunkt i en klassisk utøverpraksis, og av spenningsfeltet som oppstår mellom tradisjon, teknikk, stil og sjanger når disse konfronteres med hverandre og hybridiseres. Dynamikken mellom elementene som veves sammen, utforskes gjennom begreper og konsepter hentet fra Karen Barad: diffraksjon, intra-aksjon, agentisk kutt, re-turning og entanglement. Jeg lanserer begrepet diffraktiv refleksjon som metode for å anse materialer på nytt gjennom intra-aksjon og sammenvevinger av spacetimematter. Fortiden åpnes opp for å anses på nytt, når tid /rom blir rekonfigurert, kuttet sammen-med/fra, og vevet sammen i nye relasjoner gjennom diffraktiv refleksjon. Alle delene i prosjektet, aktivitet og eksposisjon, er forbundet – entangled. Området undersøkelsene foregår i, defineres som Grenseland. Arbeidet viser hvordan en kan åpne opp – og utfordre – en etablert praksis ved å ta i bruk nye og uvante grep fra andre praksiser.
Ionospheric response over Thailand from the 15 January 2022 eruption of the Hunga Tonga-Hunga Ha'apai volcano
Authors: Jamlongkul Paparin , wannawichian Suwicha , Paxton Larry J. , Cantrall Clayton E. , Supnithi Pornchai , Budtho Jirapoom , Nishioka Michi , Thanakulketsarat Thananphat , Thammavongsy P.
Published: March 2024

This study reports on the upper atmospheric response over Thailand to
the Hunga Tonga volcano’s eruption on January 15th, 2022. The eruption
occurred during the geomagnetic storm recovery phase, providing a rare
comparison between effects from outside (geomagnetic storm) and inside
atmosphere (volcanic eruption). About nine hours later, we observed
post-eruption fluctuations in the ionosphere total electron content
(TEC). TEC was recorded in Thailand approximately ten times remarkably
higher than typical levels from this large perturbation. The initial
impact reached Thailand with speed of ~275 m/s.
Detrended TEC (dTEC) revealed mixed wave packets at various intervals.
Two significant traveling ionospheric disturbance (TID) waves reached
Thailand at 13 UT and 14 UT, respectively. Equatorial plasma bubbles
(EPBs) were observed between 12-15 UT and 17-18 UT over Thailand. Our
findings could provide insight into how communication signals over
Thailand are affected by both disturbances, particularly in the case of
widespread volcanic eruptions.
On some inequalities of Fejér’s type using the notion of harmonic convexity
Authors: Latif Muhammad
Published: March 2024

In this study, weintroduce some new mappings in connection with
Hermite-Hadamard and Fej?r type integral inequalities which have been
proved using the harmonic convex functions. As a consequence, we discover
certain new inequalities of the Fej?r type that provide refinements of the
Hermite-Hadamard and Fej?r type integral inequalities that have already
been obtained.
Some new and general versions of q-Hermite-Hadamard-Mercer inequalities
Authors: Ali Muhammad , Budak Hüseyin , Köbis Elisabeth
Published: March 2024

In this paper, we establish two new different and general variants of
q-Hermite-Hadamard- Mercer inequalities by using the newly defined
q-integrals. The main edge of these inequalities is that they can be
converted into some existing and new inequalities for different choices of q
? (0, 1) and ? ? (0, 1] . Finally, we study some mathematical examples to
assure the validity of newly established inequalities.
The w-core inverse of a product and its applications
Authors: Yang Yuxuan , Zhu Huihui
Published: March 2024

Let R be a unital *-ring. This paper establishes necessary and sufficient
conditions for the existence of the w-core inverse of a regular element by
units in R. Then, the existence criterion of the w-core inverse of the
product of three elements are derived. As applications, the existence
criterion and expression of the w-core inverse of 2 ? 2 matrices over a ring
are given.