bluuebunny/crossref_metadata_2025 huggingface dataset:
Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells
Authors: Martins Murillo L. , Ignazzi Rosanna , Eckert Juergen , Watts Benjamin , Kaneno Ramon , Zambuzzi Willian F. , Daemen Luke , Saeki Margarida J. , Bordallo Heloisa N.
Published: March 2016

The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. From these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells.
Bilaterian-like promoters in the highly compact Amphimedon queenslandica genome
Authors: Fernandez-Valverde Selene L. , Degnan Bernard M.
Published: March 2016

The regulatory systems underlying animal development must have evolved prior to the emergence of eumetazoans (cnidarians and bilaterians). Although representatives of earlier-branching animals – sponges ctenophores and placozoans – possess most of the developmental transcription factor families present in eumetazoans, the DNA regulatory elements that these transcription factors target remain uncharted. Here we characterise the core promoter sequences, U1 snRNP-binding sites (5′ splice sites; 5′SSs) and polyadenylation sites (PASs) in the sponge Amphimedon queenslandica. Similar to unicellular opisthokonts, Amphimedon’s genes are tightly packed in the genome and have small introns. In contrast, its genes possess metazoan-like core promoters populated with binding motifs previously deemed to be specific to vertebrates, including Nrf-1 and Krüppel-like elements. Also as in vertebrates, Amphimedon’s PASs and 5′SSs are depleted downstream and upstream of transcription start sites, respectively, consistent with non-elongating transcripts being short-lived; PASs and 5′SSs are more evenly distributed in bidirectional promoters in Amphimedon. The presence of bilaterian-like regulatory DNAs in sponges is consistent with these being early and essential innovations of the metazoan gene regulatory repertoire.
The current use and attitudes towards tumor genome sequencing in breast cancer
Authors: Gingras I. , Sonnenblick A. , de Azambuja E. , Paesmans M. , Delaloge S. , Aftimos Philippe , Piccart M. J. , Sotiriou C. , Ignatiadis M. , Azim H. A.
Published: March 2016

There is increasing availability of technologies that can interrogate the genomic landscape of an individual tumor; however, their impact on daily practice remains uncertain. We conducted a 28-item survey to investigate the current attitudes towards the integration of tumor genome sequencing in breast cancer management. A link to the survey was communicated via newsletters of several oncological societies, and dedicated mailing by academic research groups. Multivariable logistic regression modeling was carried out to determine the relationship between predictors and outcomes. 215 physicians participated to the survey. The majority were medical oncologists (88%), practicing in Europe (70%) and working in academic institutions (66%). Tumor genome sequencing was requested by 82 participants (38%), of whom 21% reported low confidence in their genomic knowledge, and 56% considered tumor genome sequencing to be poorly accessible. In multivariable analysis, having time allocated to research (OR 3.37, 95% CI 1.84–6.15, p < 0.0001), working in Asia (OR 5.76, 95% CI 1.57 – 21.15, p = 0.01) and having institutional guidelines for molecular sequencing (OR 2.09, 95% 0.99–4.42, p = 0.05) were associated with a higher probability of use. In conclusion, our survey indicates that tumor genome sequencing is sometimes used, albeit not widely, in guiding management of breast cancer patients.
Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning
Authors: Chang Ching-Pang , Lee Cheng-Ta , Hou Wen-Hsien , Lin Meng-Syuan , Lai Hsing-Lin , Chien Chen-Li , Chang Chen , Cheng Pei-Lin , Lien Cheng-Chang , Chern Yijuang
Published: March 2016

The calcium-sensitive type VI adenylyl cyclase (AC6) is a membrane-bound adenylyl cyclase (AC) that converts ATP to cAMP under stimulation. It is a calcium-inhibited AC and integrates negative inputs from Ca2+ and multiple other signals to regulate the intracellular cAMP level. In the present study, we demonstrate that AC6 functions upstream of CREB and negatively controls neuronal plasticity in the hippocampus. Genetic removal of AC6 leads to cyclase-independent and N-terminus of AC6 (AC6N)-dependent elevation of CREB expression and enhances the expression of GluN2B-containing NMDA receptors in hippocampal neurons. Consequently, GluN2B-dependent calcium signaling and excitatory postsynaptic current, long-term depression and spatial reversal learning are enhanced in the hippocampus of AC6−/− mice without altering the gross anatomy of the brain. Together, our results suggest that AC6 negatively regulates neuronal plasticity by modulating the levels of CREB and GluN2B in the hippocampus.
Top-emitting quantum dots light-emitting devices employing microcontact printing with electricfield-independent emission
Authors: Liu Shihao , Liu Wenbo , Ji Wenyu , Yu Jing , Zhang Wei , Zhang Letian , Xie Wenfa
Published: March 2016

Recent breakthroughs in quantum dot light-emitting devices (QD-LEDs) show their promise in the development of next-generation displays. However, the QD-LED with conventional ITO-based bottom emission structure is difficult to realize the high aperture ratio, electricfield-independent emission and flexible full-color displays. Hence, we demonstrate top-emitting QD-LEDs with dry microcontact printing quantum dot films. The top-emitting structure is proved to be able to accelerate the excitons radiative transition rate, then contributing to stable electroluminescent efficiency with a very low roll-off and preventing spectra from shifting and broadening with the electric field increases. The results suggest potential routes towards creating high aperture ratio, wide color gamut, color-stable and flexible QD-LED displays.
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death
Authors: Ding Boxiao , Parmigiani Anita , Divakaruni Ajit S. , Archer Kellie , Murphy Anne N. , Budanov Andrei V.
Published: March 2016

Sestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target of rapamycin protein kinase (mTOR). Sestrin2 is induced by different stress insults, which diminish ATP production and induce energetic stress in the cells. Glucose is a critical substrate for ATP production utilized via glycolysis and mitochondrial respiration as well as for glycosylation of newly synthesized proteins in the endoplasmic reticulum (ER) and Golgi. Thus, glucose starvation causes both energy deficiency and activation of ER stress followed by the unfolding protein response (UPR). Here, we show that UPR induces Sestrin2 via ATF4 and NRF2 transcription factors and demonstrate that Sestrin2 protects cells from glucose starvation-induced cell death. Sestrin2 inactivation sensitizes cells to necroptotic cell death that is associated with a decline in ATP levels and can be suppressed by Necrostatin 7. We propose that Sestrin2 protects cells from glucose starvation-induced cell death via regulation of mitochondrial homeostasis.
Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37
Authors: Higashio Hironori , Satoh Yoh-ichi , Saino Tomoyuki
Published: March 2016

Mast cell degranulation is regulated by the small guanosine triphosphatases (GTPases) Rab27a and Rab27b, which have distinct and opposing roles: Rab27b acts as a positive regulator through its effector protein Munc13-4, a non-neuronal isoform of the vesicle-priming Munc13 family of proteins, whereas Rab27a acts as a negative regulator through its effector protein melanophilin, by maintaining integrity of cortical filamentous actin (F-actin), a barrier to degranulation. Here we investigated the role of Rab37, one of the Rab GTPases assumed to be implicated in regulated secretion during mast cell degranulation. Using the RBL-2H3 mast cell line, we detected Rab37 on the secretory granules and found that antigen-induced degranulation was extensively increased by either knockdown of Rab37 or overexpression of a dominant-active Rab37 mutant. This hypersecretion phenotype in the Rab37-knockdown cells was suppressed by simultaneous knockdown of Rab27a and Rab27b or of Munc13-4, but not by disruption of cortical F-actin. We further found that Rab37 interacted with Munc13-4 in a GTP-independent manner and formed a Rab27-Munc13-4-Rab37 complex. These results suggest that Rab37 is a Munc13-4-binding protein that inhibits mast cell degranulation through its effector protein, by counteracting the vesicle-priming activity of the Rab27-Munc13-4 system.
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation
Authors: Jung Bomi , Messias Ana C. , Schorpp Kenji , Geerlof Arie , Schneider Günter , Saur Dieter , Hadian Kamyar , Sattler Michael , Wanker Erich E. , Hasenöder Stefan , Lickert Heiko
Published: March 2016

Trafficking of the G protein-coupled receptor (GPCR) Smoothened (Smo) to the primary cilium (PC) is a potential target to inhibit oncogenic Hh pathway activation in a large number of tumors. One drawback is the appearance of Smo mutations that resist drug treatment, which is a common reason for cancer treatment failure. Here, we undertook a high content screen with compounds in preclinical or clinical development and identified ten small molecules that prevent constitutive active mutant SmoM2 transport into PC for subsequent Hh pathway activation. Eight of the ten small molecules act through direct interference with the G protein-coupled receptor associated sorting protein 2 (Gprasp2)-SmoM2 ciliary targeting complex, whereas one antagonist of ionotropic receptors prevents intracellular trafficking of Smo to the PC. Together, these findings identify several compounds with the potential to treat drug-resistant SmoM2-driven cancer forms, but also reveal off-target effects of established drugs in the clinics.
Linkage Between Hourly Precipitation Events and Atmospheric Temperature Changes over China during the Warm Season
Authors: Miao Chiyuan , Sun Qiaohong , Borthwick Alistair G. L. , Duan Qingyun
Published: March 2016

We investigated changes in the temporospatial features of hourly precipitation during the warm season over mainland China. The frequency and amount of hourly precipitation displayed latitudinal zonation, especially for light and moderate precipitation, which showed successive downward change over time in northeastern and southern China. Changes in the precipitation amount resulted mainly from changes in frequency rather than changes in intensity. We also evaluated the linkage between hourly precipitation and temperature variations and found that hourly precipitation extreme was more sensitive to temperature than other categories of precipitation. A strong dependency of hourly precipitation on temperature occurred at temperatures colder than the median daily temperature; in such cases, regression slopes were greater than the Clausius-Clapeyron (C-C) relation of 7% per degree Celsius. Regression slopes for 31.6%, 59.8%, 96.9% and 99.1% of all stations were greater than 7% per degree Celsius for the 75th, 90th, 99th and 99.9th percentiles for precipitation, respectively. The mean regression slopes within the 99.9th percentile of precipitation were three times the C-C rate. Hourly precipitation showed a strong negative relationship with daily maximum temperature and the diurnal temperature range at most stations, whereas the equivalent correlation for daily minimum temperature was weak.
Magnetic ordering temperature of nanocrystalline Gd: enhancement of magnetic interactions via hydrogenation-induced “negative” pressure
Authors: Tereshina E. A. , Khmelevskyi S. , Politova G. , Kaminskaya T. , Drulis H. , Tereshina I. S.
Published: March 2016

Gadolinium is a nearly ideal soft-magnetic material. However, one cannot take advantage of its properties at temperatures higher than the room temperature where Gd loses the ferromagnetic ordering. By using high-purity bulk samples with grains ~200 nm in size, we present proof-of-concept measurements of an increased Curie point (TC) and spontaneous magnetization in Gd due to hydrogenation. From first-principles we explain increase of TC in pure Gd due to the addition of hydrogen. We show that the interplay of the characteristic features in the electronic structure of the conduction band at the Fermi level in the high-temperature paramagnetic phase of Gd and “negative” pressure exerted by hydrogen are responsible for the observed effect.
Extraterritorial hunting expeditions to intense fire scars by feral cats
Authors: McGregor Hugh W. , Legge Sarah , Jones Menna E. , Johnson Christopher N.
Published: March 2016

Feral cats are normally territorial in Australia’s tropical savannahs and hunt intensively with home-ranges only two to three kilometres across. Here we report that they also undertake expeditions of up to 12.5 km from their home ranges to hunt for short periods over recently burned areas. Cats are especially likely to travel to areas burned at high intensity, probably in response to vulnerability of prey soon after such fires. The movements of journeying cats are highly directed to specific destinations. We argue that the effect of this behaviour is to increase the aggregate impact of cats on vulnerable prey. This has profound implications for conservation, considering the ubiquity of feral cats and global trends of intensified fire regimes.
Conduction Threshold in Accumulation-Mode InGaZnO Thin Film Transistors
Authors: Lee Sungsik , Nathan Arokia
Published: March 2016

The onset of inversion in the metal-oxide-semiconductor field-effect transistor (MOSFET) takes place when the surface potential is approximately twice the bulk potential. In contrast, the conduction threshold in accumulation mode transistors, such as the oxide thin film transistor (TFT), has remained ambiguous in view of the complex density of states distribution in the mobility gap. This paper quantitatively describes the conduction threshold of accumulation-mode InGaZnO TFTs as the transition of the Fermi level from deep to tail states, which can be defined as the juxtaposition of linear and exponential dependencies of the accumulated carrier density on energy. Indeed, this permits direct extraction and visualization of the threshold voltage in terms of the second derivative of the drain current with respect to gate voltage.
Specific LED-based red light photo-stimulation procedures improve overall sperm function and reproductive performance of boar ejaculates
Authors: Yeste Marc , Codony Francesc , Estrada Efrén , Lleonart Miquel , Balasch Sam , Peña Alejandro , Bonet Sergi , Rodríguez-Gil Joan E.
Published: March 2016

The present study evaluated the effects of exposing liquid-stored boar semen to different red light LED regimens on sperm quality and reproductive performance. Of all of the tested photo-stimulation procedures, the best pattern consisted of 10 min light, 10 min rest and 10 min of further light (10-10-10 pattern). This pattern induced an intense and transient increase in the majority of motility parameters, without modifying sperm viability and acrosome integrity. While incubating non-photo-stimulated sperm at 37 °C for 90 min decreased all sperm quality parameters, this reduction was prevented when the previously-described light procedure was applied. This effect was concomitant with an increase in the percentage of sperm with high mitochondrial membrane potential. When sperm were subjected to ‘in vitro’ capacitation, photo-stimulation also increased the percentage of sperm with capacitation-like changes in membrane structure. On the other hand, treating commercial semen doses intended for artificial insemination with the 10-10-10 photo-stimulation pattern significantly increased farrowing rates and the number of both total and live-born piglets for parturition. Therefore, our results indicate that a precise photo-stimulation procedure is able to increase the fertilising ability of boar sperm via a mechanism that could be related to mitochondrial function.
Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 ‘Sponge’ in Human Cartilage Degradation
Authors: Liu Qiang , Zhang Xin , Hu Xiaoqing , Dai Linghui , Fu Xin , Zhang Jiying , Ao Yingfang
Published: March 2016

Circular RNAs (circRNAs) are involved in the development of various diseases, but there is little knowledge of circRNAs in osteoarthritis (OA). The aim of study was to identify circRNA expression in articular cartilage and to explore the function of chondrocyte extracellular matrix (ECM)-related circRNAs (circRNA-CER) in cartilage. To identify circRNAs that are specifically expressed in cartilage, we compared the expression of circRNAs in OA cartilage with that in normal cartilage. Bioinformatics was employed to predict the interaction of circRNAs and mRNAs in cartilage. Loss-of-function and rescue experiments for circRNA-CER were performed in vitro. A total of 71 circRNAs were differentially expressed in OA and normal cartilage. CircRNA-CER expression increased with interleukin-1 and tumor necrosis factor levels in chondrocytes. Silencing of circRNA-CER using small interfering RNA suppressed MMP13 expression and increased ECM formation. CircRNA-CER could compete for miR-136 with MMP13. Our results demonstrated that circRNA-CER regulated MMP13 expression by functioning as a competing endogenous RNA (ceRNA) and participated in the process of chondrocyte ECM degradation. We propose that circRNA-CER could be used as a potential target in OA therapy.
Colour and pattern change against visually heterogeneous backgrounds in the tree frog Hyla japonica
Authors: Kang Changku , Kim Ye Eun , Jang Yikweon
Published: March 2016

Colour change in animals can be adaptive phenotypic plasticity in heterogeneous environments. Camouflage through background colour matching has been considered a primary force that drives the evolution of colour changing ability. However, the mechanism to which animals change their colour and patterns under visually heterogeneous backgrounds (i.e. consisting of more than one colour) has only been identified in limited taxa. Here, we investigated the colour change process of the Japanese tree frog (Hyla japonica)against patterned backgrounds and elucidated how the expression of dorsal patterns changes against various achromatic/chromatic backgrounds with/without patterns. Our main findings are i) frogs primarily responded to the achromatic differences in background, ii) their contrasting dorsal patterns were conditionally expressed dependent on the brightness of backgrounds, iii) against mixed coloured background, frogs adopted intermediate forms between two colours. Using predator (avian and snake) vision models, we determined that colour differences against different backgrounds yielded perceptible changes in dorsal colours. We also found substantial individual variation in colour changing ability and the levels of dorsal pattern expression between individuals. We discuss the possibility of correlational selection on colour changing ability and resting behaviour that maintains the high variation in colour changing ability within population.
MiR-590-5p Inhibits Oxidized- LDL Induced Angiogenesis by Targeting LOX-1
Authors: Dai Yao , Zhang Zhigao , Cao Yongxiang , Mehta Jawahar L. , Li Jun
Published: March 2016

Oxidized low-density lipoprotein (ox-LDL) is, at least in part, responsible for angiogenesis in atherosclerotic regions. This effect of ox-LDL has been shown to be mediated through a specific receptor LOX-1. Here we describe the effect of miR-590-5p on ox-LDL-mediated angiogenesis in in vitro and in vivo settings. Human umbilical vein endothelial cells (HUVECs) were transfected with miR-590-5p mimic or inhibitor followed by treatment with ox-LDL. In other experiments, Marigel plugs were inserted in the mice subcutaneous space. Both in vitro and in vivo studies showed that miR-590-5p mimic (100 nM) inhibited the ox-LDL-mediated angiogenesis (capillary tube formation, cell proliferation and migration as well as pro-angiogenic signals- ROS, MAPKs, pro-inflammatory cytokines and adhesion-related proteins). Of note, miR-590-5p inhibitor (200 nM) had the opposite effects. The inhibitory effect of miR-590-5p on angiogenesis was mediated by inhibition of LOX-1 at translational level. The inhibition of LOX-1 by miR-590-5p was confirmed by luciferase assay. In conclusion, we show that MiR-590-5p inhibits angiogenesis by targeting LOX-1 and suppressing redox-sensitive signals.
Low-Power Light Guiding and Localization in Optoplasmonic Chains Obtained by Directed Self-Assembly
Authors: Ahn Wonmi , Zhao Xin , Hong Yan , Reinhard Björn M.
Published: March 2016

Optoplasmonic structures contain plasmonic components embedded in a defined photonic environment to create synergistic interactions between photonic and plasmonic components. Here, we show that chains of optical microspheres containing gold nanoparticles in their evanescent field combine the light guiding properties of a microsphere chain with the light localizing properties of a plasmonic nanoantenna. We implement these materials through template guided self-assembly and investigate their fundamental electromagnetic working principles through combination of electromagnetic simulations and experimental characterization. We demonstrate that optoplasmonic chains implemented by directed self-assembly achieve a significant reduction in guiding losses when compared with conventional plasmonic waveguides and, at the same time, retain the light localizing properties of plasmonic antennas at pre-defined locations. The results reinforce the potential of optoplasmonic structures for realizing low-loss optical interconnects with high bandwidth.
Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling
Authors: Zhao Shan , Dai Jianye , Hu Mo , Liu Chang , Meng Rong , Liu Xiaoyun , Wang Chu , Luo Tuoping
Published: March 2016

The coupling reactions of diaryltetrazoles with carboxylic acids under UV irradiation were investigated. Application of these transformations in chemical biology was demonstrated in photo-labelling the proteinogenic carboxylic acids in purified proteins, cell lysates and living cells.
High performance perovskite solar cell via multi-cycle low temperature processing of lead acetate precursor solutions
Authors: Singh Trilok , Miyasaka Tsutomu
Published: March 2016

A lead acetate-based precursor, as a lead source in CH3NH3PbI3 perovskite, showed potential in rapidly (<60 seconds) forming homogeneous films with a very smooth interface and large grain growth at relatively low temperatures via multi-step coating.
Fabrication of FeOOH hollow microboxes for purification of heavy metal-contaminated water
Authors: Wang Sida , Lan Huachun , Liu Huijuan , Qu Jiuhui
Published: March 2016

We fabricated FeOOH hollow microboxes constructed from numerous 2D nanosheets via a template-engaged reaction between Prussian blue (PB) and NaOH solution, which showed superior adsorptive performance in the purification of aqueous heavy metals.
Semiempirical QM/MM calculations reveal a step-wise proton transfer and an unusual thiolate pocket in the mechanism of the unique arylpropionate racemase AMDase G74C
Authors: Busch F. , Enoki J. , Hülsemann N. , Miyamoto K. , Bocola M. , Kourist R.
Published: March 2016

Semiempirical calculations on the mechanism of the arylpropionate racemase AMDase G74C reveal a step-wise mechanism involving a planar-enedionate intermediate.
Multiscale structural characterizations of mixed U(iv)–An(iii) oxalates (An(iii) = Pu or Am) combining XAS and XRD measurements
Authors: Arab-Chapelet B. , Martin P. M. , Costenoble S. , Delahaye T. , Scheinost A. C. , Grandjean S. , Abraham F.
Published: March 2016

Thorough XRD and XAS measurements confirmed the existence of M2.2UIV1.8AnIII0.2(C2O4)5·nH2O (An = Pu or Am) oxalate solid solutions.
Aluminum methyl, alkoxide and α-alkoxy ester complexes supported by 6,6′-dimethylbiphenyl-bridged salen ligands: synthesis, characterization and catalysis for rac-lactide polymerization
Authors: Kan Chao , Ge Jilei , Ma Haiyan
Published: March 2016

A series of mono- and dinuclear salen aluminum complexes could efficiently catalyze the ROP of rac-LA, producing isotactic enriched and atactic PLA, respectively. In solution, the association/dissociation equilibrium of the carbonyl group was found in the model O-lactate complexes.
Complete voltage recovery in quantum dot solar cells due to suppression of electron capture
Authors: Varghese A. , Yakimov M. , Tokranov V. , Mitin V. , Sablon K. , Sergeev A. , Oktyabrsky S.
Published: March 2016

The quantum dot solar cell with nanoengineered suppression of photoelectron capture show the same open circuit voltage as the GaAs reference cell together with some improvements in the short circuit current.
Investigations on Nb2C monolayer as promising anode material for Li or non-Li ion batteries from first-principles calculations
Authors: Hu Junping , Xu Bo , Ouyang Chuying , Zhang Ying , Yang Shengyuan A.
Published: March 2016

The metallicity, high capacities, fast diffusion and low average intercalation potentials make Nb2C monolayer a promising LIBs/NLIBs anode.
Impact of blend ratio on the co-firing of post-methanated distillery effluent solid waste and low-rank Indian coal via analysis of oxidation kinetics through TGA
Authors: Naveen C. , Premalatha M.
Published: March 2016

An attempt has been made to study the oxidation kinetics of dried Post-Methanated Distillery Effluent (PMDE) solid waste blended with Low Rank Indian Coal (LRIC) at different blending ratios in a thermogravimetric analyzer (TGA).
A new, efficient and recyclable [Ce(l-Pro)]2(Oxa) heterogeneous catalyst used in the Kabachnik–Fields reaction
Authors: da Silva Caren D. G. , Oliveira Aline R. , Rocha Mariana P. D. , Katla Ramesh , Botero Eriton Rodrigo , da Silva Érica C. , Domingues Nelson Luís C.
Published: March 2016

We report an eco-friendly, easy and efficient methodology for the synthesis of α-aminophosphonates using [Ce(l-Pro)]2(Oxa) as a catalyst.
Removal of bisphenol A by iron nanoparticle-doped magnetic ordered mesoporous carbon
Authors: Tang Lin , Xie Zhihong , Zeng Guangming , Dong Haoran , Fan Changzheng , Zhou Yaoyu , Wang Jiajia , Deng Yaocheng , Wang Jingjing , Wei Xue
Published: March 2016

Iron nanoparticle-doped magnetic ordered mesoporous carbon (Fe/OMC) was prepared by co-impregnation and carbothermal reduction methods, and used for highly effective adsorption and degradation of bisphenol A (BPA).
Novel synthesis of Dy2Ce2O7nanostructures via a facile combustion route
Authors: Salehi Zahra , Zinatloo-Ajabshir Sahar , Salavati-Niasari Masoud
Published: March 2016

Dy2Ce2O7nanostructures were synthesized by a new facile salt-assisted combustion way.
Correction function for biased results due to matrix effects in residue analysis of beta-agonists in porcine tissues and urine with LC-MS/MS
Authors: Wang LiQi , Zeng ZhenLing , Wang Zhong , He LiMin
Published: March 2016

A correction function is proposed to compensate for matrix effects in the residue analysis of nine β-agonists by liquid chromatography tandem mass spectrometry.
Preparation of porous cadmium sulphide on nickel foam: a novel electrode material with excellent supercapacitor performance
Authors: Xu Panpan , Liu Jijun , Yan Peng , Miao Chenxu , Ye Ke , Cheng Kui , Yin Jinling , Cao Dianxue , Li Kaifeng , Wang Guiling
Published: March 2016

Large surface area, high electrical conductivity, and abundant channels have been recognized to favor faradic capacitors, but their realization at the same time by a facile preparation process is still a great challenge.
In situ creating interconnected pores across 3D graphene architectures and their application as high performance electrodes for flow-through deionization capacitors
Authors: Wang Hui , Yan Tingting , Liu Peiying , Chen Guorong , Shi Liyi , Zhang Jianping , Zhong Qingdong , Zhang Dengsong
Published: March 2016

3D graphene architectures with ample micro-/mesopores across the highly interconnected macroporous walls exhibit a good performance in capacitive deionization.
Fluorescent nitrogen-rich carbon nanodots with an unexpected β-C3N4nanocrystalline structure
Authors: Messina F. , Sciortino L. , Popescu R. , Venezia A. M. , Sciortino A. , Buscarino G. , Agnello S. , Schneider R. , Gerthsen D. , Cannas M. , Gelardi F. M.
Published: March 2016

We report on nitrogen-doped carbon dots having a β-C3N4crystalline structure and yielding bright tunable fluorescence.
Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids
Authors: Wojdyla Katarzyna , Wrzesinski Krzysztof , Williamson James , Fey Stephen J. , Rogowska-Wrzesinska Adelina
Published: March 2016

Acetaminophen (APAP) is possibly the most widely used medication globally and yet little is known of its molecular effects at therapeutic doses.
A zwitterionic macro-crosslinker for durable non-fouling coatings
Authors: Wang Wei , Lu Yang , Xie Jinbing , Zhu Hui , Cao Zhiqiang
Published: March 2016

A novel zwitterionic macro-crosslinker coating achieved superior durability over the traditional brush polymer coating.
Iodosylbenzene and iodylbenzene adducts of cerium(iv) complexes bearing chelating oxygen ligands
Authors: Au-Yeung Ka-Chun , So Yat-Ming , Wang Guo-Cang , Sung Herman H.-Y. , Williams Ian D. , Leung Wa-Hung
Published: March 2016

Reactions of [CeIV(LOEt)2Cl2] (LOEt− = [Co(η5-C5H5){P(O)(OEt)2}3]−) with PhIO and PhIO2 afford [CeIV(LOEt)2{OI(Cl)Ph}2] and [CeIV(LOEt)2{OI(O)ClPh}2], respectively, which have been characterised by X-ray crystallography.
A novel photo-responsive europium(iii) complex for advanced anti-counterfeiting and encryption
Authors: Mei Jin-Feng , Lv Zhong-Peng , Lai Jian-Cheng , Jia Xiao-Yong , Li Cheng-Hui , Zuo Jing-Lin , You Xiao-Zeng
Published: March 2016

By using light as external stimuli to modulate the multiple distinguishable identities of a novel photo-responsive europium(iii) complex, advanced anti-counterfeiting and double encryption were realized.
Unprecedented layered coordination polymers of dithiolene group 10 metals: magnetic and electrical properties
Authors: Delgado Esther , Gómez-García Carlos J. , Hernández Diego , Hernández Elisa , Martín Avelino , Zamora Félix
Published: March 2016

One-pot reactions between Ni(ii), Pd(ii) or Pt(ii) salts and 3,6-dichloro-1,2-benzenedithiol (HSC6H2Cl2SH) in KOH medium under argon lead to a series of bis-dithiolene coordination polymers.
Correction: Self-assembly of arene ruthenium acylpyrazolone fragments to tetranuclear metallacycles. Molecular structures and solid-state 15N CPMAS NMR correlations
Authors: Pettinari Riccardo , Marchetti Fabio , Pettinari Claudio , Condello Francesca , Skelton Brian W. , White Allan H. , Chierotti Michele R. , Gobetto Roberto
Published: March 2016

Correction for ‘Self-assembly of arene ruthenium acylpyrazolone fragments to tetranuclear metallacycles. Molecular structures and solid-state 15N CPMAS NMR correlations’ by Riccardo Pettinari et al., Dalton Trans., 2016, 45, 3974–3982.
Research highlights: functions of the drinking water microbiome – from treatment to tap
Authors: Gomez-Smith C. Kimloi , Tan David T. , Shuai Danmeng
Published: March 2016

We highlight determinants and functions of the drinking water microbiome in water treatment processes, distribution system biofilms, and premise plumbing components.
Synthesis of Janus plasmonic–magnetic, star–sphere nanoparticles, and their application in SERS detection
Authors: Reguera Javier , Jiménez de Aberasturi Dorleta , Winckelmans Naomi , Langer Judith , Bals Sara , Liz-Marzán Luis M.
Published: March 2016

Multicomponent nanoparticles are of particular interest due to a unique combination of properties at the nanoscale, which make them suitable for a wide variety of applications. Among them, Janus nanoparticles, presenting two distinct surface regions, can lead to specific interactions with interfaces, biomolecules, membranes etc. We report the synthesis of Janus nanoparticles comprising iron oxide nanospheres and gold nanostars, through two consecutive seed-mediated-growth steps. Electron tomography combining HAADF-STEM and EDX mapping has been performed to evaluate the spatial distribution of the two components of the nanoparticle, showing their clear separation in a Janus morphology. Additionally, SERS measurements assisted by magnetic separation were carried out to assess the application of combined plasmonic and magnetic properties for sensing.
Self-folding nanostructures with imprint patterned surfaces (SNIPS)
Authors: Kwag Hye Rin , Cho Jeong-Hyun , Park Si-Young , Park Jaehyun , Gracias David H.
Published: March 2016

A significant need in nanotechnology is the development of methods to mass-produce three-dimensional (3D) nanostructures and their ordered assemblies with patterns of functional materials such as metals, ceramics, device grade semiconductors, and polymers. While top-down lithography approaches can enable heterogeneous integration, tunability, and significant material versatility, these methods enable inherently two-dimensional (2D) patterning. Bottom-up approaches enable mass-production of 3D nanostructures and their assemblies but with limited precision, and tunability in surface patterning. Here, we demonstrate a methodology to create Self-folding Nanostructures with Imprint Patterned Surfaces (SNIPS). By a variety of examples, we illustrate that SNIPS, either individually or in ordered arrays, are mass-producible and have significant tunability, material heterogeneity, and patterning precision.
Continuous cell sorting in a flow based on single cell resonance Raman spectra
Authors: McIlvenna David , Huang Wei E. , Davison Paul , Glidle Andrew , Cooper Jon , Yin Huabing
Published: March 2016

A chip-based Raman activated cell sorting system is developed, which demonstrates continuous and automated sorting of individual cells in a flow, based on their intrinsic resonance Raman spectra. This platform allows the isolation of cells in their native fluid with the ability to achieve high accuracy sorting of 96.3%.
Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?
Authors: de Almeida A. , Martins A. P. , Mósca A. F. , Wijma H. J. , Prista C. , Soveral G. , Casini A.
Published: March 2016

The pH gating of human AQP3 and its effects on both water and glycerol permeabilities have been fully characterized for the first time using a human red blood cell model (hRBC).
Immunological evaluation of the entirely carbohydrate-based Thomsen-Friedenreich – PS B conjugate
Authors: Trabbic Kevin R. , Bourgault Jean-Paul , Shi Mengchao , Clark Matthew , Andreana Peter R.
Published: March 2016

PS B, a CD4+T-cell stimulating zwitterionic polysaccharide fromB. fragilis, was conjugated with aminooxy TF tumor antigen. Immunization revealed Ab specificity to TF. FACS revealed Ab binding to MCF-7 but not HCT-116 cells.
Hydrogen bonding strength effect on self-assembly supramolecular structures of diblock copolymer/homopolymer blends
Authors: Tsai Shih-Chi , Lin Yung-Chih , Lin En-Li , Chiang Yeo-Wan , Kuo Shiao-Wei
Published: March 2016

The steric hindrance effect on the hydrogen bonding strength and self-assembly supramolecular structures of the PS-b-PVPh diblock copolymer when blended with P4VP and P2VP homopolymers was investigated.
Organosoluble and high Tgpolyimides from asymmetric diamines containing N-amino and N-aminophenyl naphthalimide moieties
Authors: Mushtaq Nafeesa , Chen Guofei , Sidra Lala Rukh , Fang Xingzhong
Published: March 2016

Two series of polyimides derived from two asymmetric diamines are synthesised by different polymerization methods. The effect of asymmetry and non-coplanarity of two bisimides on the polymer properties is well investigated.
A metabolomics-based approach for ranking the depressive level in a chronic unpredictable mild stress rat model
Authors: Yu Xinyu , Qiao Shanlei , Wang Di , Dai Jiayong , Wang Jun , Zhang Rutan , Wang Li , Li Lei
Published: March 2016

An untargeted metabolomics study to investigate the metabolome change in plasma, hippocampus and prefrontal cortex (PFC) in an animal model with a major depressive disorder (MDD) had been conducted.
A diquinone–imidazole ensemble for selective colorimetric sensing of cyanide in aqueous medium via anion induced NIR absorption
Authors: Jayasudha Palanisamy , Manivannan Ramalingam , Elango Kuppanagounder P.
Published: March 2016

The receptor selectively and sensitively senses cyanide ions in aqueous solution with a striking colour changeviaanion induced NIR absorption (913 nm).
Lewis-acid catalyzed synthesis and characterization of novel castor fatty acid-based cyclic carbonates
Authors: Narra Naganna , Prasad Rachapudi Badari Narayana , Phani Babu Vemulapalli Sahithya , Korlipara Padmaja V.
Published: March 2016

Novel bio-based cyclic carbonates were synthesised from ricinoleic acid by intra molecular rearrangement of an epoxy carbonate ester with Lewis acids.
Efficient degradation of methylene blue over boron-doped g-C3N4/Zn0.8Cd0.2S photocatalysts under simulated solar irradiation
Authors: Tian Wei , Shen Quanhao , Li Naixu , Zhou Jiancheng
Published: March 2016

Boron doping and heterostructures are closely related to the enhanced photocatalytic function of the hybrids.
Hydrogen production from biomass by continuous fast pyrolysis and in-line steam reforming
Authors: Arregi A. , Lopez G. , Amutio M. , Barbarias I. , Bilbao J. , Olazar M.
Published: March 2016

The continuous fast pyrolysis of pine wood sawdust has been studied in a conical spouted bed reactor (CSBR) followed by in-line steam reforming of the pyrolysis vapours in a fluidised bed reactor on a Ni commercial catalyst.
Surface modification of LaFeO3 by Co-Pi electrochemical deposition as an efficient photoanode under visible light
Authors: Peng Q. , Wang J. , Wen Y. W. , Shan B. , Chen R.
Published: March 2016

The PEC performance of LaFeO3 is promoted by Co-Pi coating due to improved surface catalytic activity and enhanced carrier separation.
Novel carbon nanofiber-supported Ni(0) nanoparticles catalyse the Heck reaction under ligand-free conditions
Authors: Zhu Ying , Bai Jie , Wang Junzhong , Li Chunping
Published: March 2016

Ni(0)/CNFs was one-dimensional morphology, and the average size of Ni nanoparticles sheathed by CNFs is 14 nm. Solid Ni(0)/CNFs can catalyse Heck reaction high-efficiently.
Towards the understanding of non-thermal air plasma action: effects on bacteria and fibroblasts
Authors: Lunov Oleg , Zablotskii Vitalii , Churpita Olexander , Jäger Ales , Polívka Leoš , Syková Eva , Terebova Natalia , Kulikov Andrei , Kubinová Šárka , Dejneka Alexandr
Published: March 2016

Non-thermal plasma research has put a growing focus on the bacteria inactivation problem. Here we show how non-thermal plasma destroys Gram-positive and Gram-negative bacteria and discuss the mechanisms of plasma bactericidal effects.
Electrochemiluminescent molecular logic gates based on MCNTs for the multiplexed analysis of mercury(ii) and silver(i) ions
Authors: Liu Haiyun , Zhang Lina , Li Meng , Yan Mei , Xue Mei , Zhang Yan , Su Min , Yu Jinghua , Ge Shenguang
Published: March 2016

In this paper, logic gates with electrochemiluminescence (ECL) signal as outputs were constructed based on the use of the thymine (T)-rich (S1) or cytosine (C)-rich (S2) oligonucleotides for the selective analysis of mercury ions (Hg2+) or silver ions (Ag+).
Layer-by-layer assembled PMMA-SH/CdSe–Au nanocomposite thin films and the optical limiting property
Authors: Jin Feng , Zheng Mei-Ling , Liu Zheng-Hui , Fan Yi-Ming , Xu Ke , Zhao Zhen-Sheng , Duan Xuan-Ming
Published: March 2016

We demonstrate layer-by-layer assembly of PMMA-SH/CdSe–Au nanocomposite thin films with good transparency, thermal stability and optical liming property, which provide potential uses in laser protective devices.
Design and development of an in situ synthesized layered double hydroxide structure of Fe-induced hydroxyapatite for drug carriers
Authors: Manna Ayan , Pramanik Sumit , Tripathy Ashis , Radzi Zamri , Moradi Ali , Pingguan-Murphy Belinda , Abu Osman Noor Azuan
Published: March 2016

Possible mechanisms: (i) formation of LDH structure of Fe-induced hydroxyapatite (HA), (ii) intercalation of Aceclofenac (AF) drug in LDH structure of FH carriers and (iii) releasing of drug via hydrolysis and/or reaction with other biomolecules.
Lead adsorption from aqueous solutions by a granular adsorbent prepared from phoenix tree leaves
Authors: Liang Sha , Ye Nan , Hu Yuchen , Shi Yafei , Zhang Wei , Yu Wenbo , Wu Xu , Yang Jiakuan
Published: March 2016

In this study, a granular adsorbent was prepared from phoenix tree leaf powder with bentonite as the binder. The adsorption kinetics and isotherms of Pb2+ removal by the 500 °C-calcined granular adsorbent were studied by various models.
Electrodeposition of Au nanoparticles on poly(diallyldimethylammonium chloride) functionalized reduced graphene oxide sheets for voltammetric determination of nicotine in tobacco products and anti-smoking pharmaceuticals
Authors: Jing Yanqiu , Lin Erge , Su Xinhong , Liu Yingjie , Li Huaiqi , Yuan Xiuxiu , Ping Lu , Fan Yikuan
Published: March 2016

The principal objective of this study was to develop a sensitive and selective electrochemical sensor for nicotine detection based on a novel PDDA-RGO/Au nanocomposite.
Overcoming naphthoquinone deactivation: rhodium-catalyzed C-5 selective C–H iodination as a gateway to functionalized derivatives
Authors: Jardim Guilherme A. M. , da Silva Júnior Eufrânio N. , Bower John F.
Published: March 2016

Rh-catalyzed C-5 selective C–H iodination of naphthoquinones provides a gateway to previously inaccessible A-ring analogues. C-2 selective processes can be achieved under related conditions.
A synergistic effect between layer surface configurations and K ions of potassium vanadate nanowires for enhanced energy storage performance
Authors: Meng Jiashen , Liu Ziang , Niu Chaojiang , Xu Xiaoming , Liu Xiong , Zhang Guobin , Wang Xuanpeng , Huang Meng , Yu Yang , Mai Liqiang
Published: March 2016

In this work, the origin of enhanced electrochemical performance of potassium vanadates was investigated.
Twofold photoswitching of NIR fluorescence and EPR based on the PMI–N–HABI for optical nanoimaging of electrospun polymer nanowires
Authors: Gong Wen-Liang , Xiong Zu-Jing , Xin Bo , Yin Hong , Duan Jia-Shun , Yan Jie , Chen Tao , Hua Qiong-Xin , Hu Bin , Huang Zhen-Li , Zhu Ming-Qiang
Published: March 2016

A fluorescent dyad constituted by HABI and PMI with photo-induced NIR fluorescence and EPR has been reported and applied to optical nanoimaging of electrospun polymer nanowires.
Human C-reactive protein impedes entry of leptin into the CNS and attenuates its physiological actions in the CNS
Authors: Li Jie , Wei Dong , McCrory Mark A. , Szalai Alexander J. , Yang Gangyi , Li Ling , Li Fanghong , Zhao Allan Z.
Published: March 2016

Defective central leptin signalling and impaired leptin entry into the CNS (central nervous system) represent two important aspects of leptin resistance in obesity. In the present study, we tested whether circulating human CRP (C-reactive protein) not only diminishes signalling of leptin within the CNS, but also impedes this adipokine's access to the CNS. Peripheral infusion of human CRP together with co-infused human leptin was associated with significantly decreased leptin content in the CSF of ob/ob mice. Furthermore, following peripheral infusion of human leptin, the CSF (cerebrospinal fluid) concentration of leptin in transgenic mice overexpressing human CRP was sharply lower than that achieved in similarly infused wild-type mice. Administration of LPS (lipopolysaccharide) to human CRP-transgenic mice dramatically elevated the concentrations of human CRP in the CSF. The i.c.v. (intracerebroventricular) delivery of human CRP into the lateral ventricles of ob/ob mice blocked the satiety and weight-reducing actions of human leptin, but not those of mouse leptin. I.c.v. injection of human CRP abolished hypothalamic signalling by human leptin, and ameliorated the effects of leptin on the expression of NPY (neuropeptide Y), AgRP (Agouti-related protein), POMC (pro-opiomelanocortin) and SOCS-3 (suppressor of cytokine signalling 3). Human CRP can impede the access of leptin to the CNS, and elevation of human CRP within the CNS can have a negative impact on the physiological actions of leptin.
Beamforming optimisation in energy harvesting cooperative full‐duplex networks with self‐energy recycling protocol
Authors: Hu Shiyang , Ding Zhiguo , Ni Qiang
Published: March 2016

This study considers the problem of beamforming optimisation in an amplify‐and‐forward relaying cooperative network, in which the relay node harvests the energy from the radio‐frequency signal. Based on the self‐energy recycling relay protocol, the authors study the beamforming optimisation problem. The formulated problem aims to maximise the achievable rate subject to the available transmitted power at the relay node. The authors develop a semidefinite programming (SDP) relaxation method to solve the proposed problem. They also use SDP and the full search to solve the beamforming optimisation based on a time‐switching relaying protocol as a benchmark. The simulation results are presented to verify that the self‐energy recycling protocol achieves a significant rate gain compared with the time‐switching relaying protocol and the power‐splitting relaying protocol.
Joint versus separate spectrum sensing and resource allocation in OFDMA‐based cognitive radio networks
Authors: Janatian Nafiseh , Modarres‐Hashemi Mahmood , Sun Sumei
Published: March 2016

In this study, the authors investigate the resource allocation issue for sensing‐based orthogonal frequency‐division multiple access (OFDMA) cognitive radio networks. They consider a network consisting multiple secondary users (SUs) and a secondary base station (BS) implementing a two‐phase protocol. In the first phase, cooperative spectrum sensing is carried out to detect the vacant subchannels. In the second phase, SUs transmit data in the uplink to the BS by using OFDMA. They optimise the sensing parameters, transmit power and subchannel assignments jointly to minimise the total energy consumption with the constraints on SUs’ quality of service and detection probability of the primary user. This is a mixed binary integer programming problem which is NP (non‐deterministic polynomial‐time)‐hard and generally intractable. They represent the problem as a bilevel problem and propose two efficient algorithms to solve the slave and master subproblems. They also study the separate optimisation, in which the sensing parameters of SUs are set regardless of the allocated resources. They investigate the energy savings of joint versus separate optimisation using numerical experiments. The results show that the joint optimisation method can introduce up to 16% of energy saving in zero sensing signal‐to‐noise ratio with the same total transmission bandwidth of 2.5 MHz.