bluuebunny/crossref_metadata_2025 huggingface dataset:
Some Improvements of Jensen’s Inequality via 4-Convexity and Applications
Authors: Ullah Hidayat , Adil Khan Muhammad , Saeed Tareq , Sayed Zaid Mohammed Mohammed Mahdi
Published: January 2022

The intention of this note is to investigate some new important estimates for the Jensen gap while utilizing a 4-convex function. We use the Jensen inequality and definition of convex function in order to achieve the required estimates for the Jensen gap. We acquire new improvements of the Hölder and Hermite–Hadamard inequalities with the help of the main results. We discuss some interesting relations for quasi-arithmetic and power means as consequences of main results. At last, we give the applications of our main inequalities in the information theory. The approach and techniques used in the present note may simulate more research in this field.
Monitoring, Prediction, and Evaluation of Mountain Geological Hazards Based on InSAR Technology
Authors: Yang Fan , Jiang Zhongrong , Ren Junqian , Lv Jian
Published: January 2022

When traditional geological hazard survey methods are used for deformation monitoring in mountainous areas, it often shows the disadvantages of low applicability of monitoring methods and limited accuracy of detection results. In recent years, synthetic aperture radar interferometry (InSAR) technology has incomparable advantages in surface deformation monitoring, such as all-weather detection, wide detection range, high detection accuracy, and low detection cost. At the same time, InSAR technology can also provide data and technical support for the subsequent task of potential geological disaster point identification and geological disaster risk zoning in the study area. Alos-2 radar is selected; in this paper the satellite image is the research data, and the InSAR technology is used to complete the surface deformation detection. Then, based on the previous surface deformation monitoring results, the potential geological disaster points in the study area are extracted, and the distribution law and incubation conditions of the disaster points are analyzed and described. According to the field conditions of a certain area, the surface distribution, development causes, and inducing mechanism of the potential geological disaster points are explored; the results show that the development of geological disasters in the study area is affected by many factors such as landform, geological environment, climate, hydrology, and human activities. Based on this, 11 factors such as formation lithology, slope, and river are used as evaluation factors for mountain geological disaster monitoring, prediction, and evaluation analysis. Finally, the improved analytic hierarchy process information model is used to complete the monitoring, prediction, evaluation, and analysis of regional geological hazards in the study area. In this paper, the improved AHP-information method is used to classify the risk of mountain geological disasters in the study area. Finally, the evaluation results are verified, which proves that the improved AHP-information method is reliable, and its mountain geological disaster monitoring and prediction evaluation effect is better than the traditional AHP-information method.
miR-335-5p Inhibits Progression of Uterine Leiomyoma by Targeting ARGLU1
Authors: Zhao Wei , Zhao Yingyan , Chen Ling , Sun Yan , Fan Sumei
Published: January 2022

Studies have demonstrated that miR-335-5p exhibits an essential role in the progress of multiple tumors, including thyroid cancer, pancreatic cancer, and non-small-cell lung cancer. However, the possible expression, the detailed role, and the underlying mechanisms of miR-335-5p in uterine leiomyoma (UL) still remained unclear. Therefore, the present study was designed to investigate the mechanism and function of miR-335-5p in UL. In our study, microRNA-335-5p (miR-335-5p) is significantly downregulated in UL tissues and UL cell lines, especially in HCC1688 and SK-UT-1 cells. Functionally, overexpression of miR-335-5p notably inhibits the viability of UL cell lines by CCK-8 assay. Besides, upregulation of miR-335-5p inhibits proliferation of UL cell lines by colony formation assay and decreases the protein levels of PCNA and Ki-67 detected by western blot assay. In addition, overexpression of miR-335-5p induces UL cell cycle arrest at G1 phase. Upregulation of miR-335-5p decreases the levels of Cyclin A1, Cyclin B1, and Cyclin D2 and upregulates the expression of p27 protein. Additionally, upregulation of miR-335-5p promotes the apoptosis of UL cell lines, increases the protein levels of Bax, Cleaved caspase-3, and Cleaved caspase-9, and decreases the protein expression of Bcl-2. Moreover, Arginine and Glutamate-Rich protein 1 (ARGLU1) is predicted as a target of miR-335-5p by ENCORI and miRDB and confirmed by dual-luciferase reporter assay. ARGLU1 is negatively associated with miR-335-5p. Furthermore, overexpression of ARGLU1 partly restores the effects of miR-335-5p mimic on the viability, proliferation, cell cycle, and apoptosis of UL cell lines. To conclude, miR-335-5p may play a repressive role in UL by targeting ARGLU1 and serve as a potential therapeutic target for the treatment of UL.
Research on the Application of CAD Auxiliary Intelligent Technology in Sports
Authors: Wang Wenhong
Published: January 2022

This paper mainly combines CAD auxiliary intelligent technology and image processing technology, by combining the experience and creativity of sports coaches and sports researchers, and using modern technology, it can design and efficiently study sports quickly, conveniently, and efficiently and uses advanced high-tech technology to replace the traditional relatively backward artificial design method of sports. In the field of sports, in-depth research and scientific research and feasibility analysis can be conducted, so as to realize the design of CAD auxiliary intelligent technology system for sports competitive movements. Finally, the experimental results show the CAD auxiliary intelligence technology in sports to verify the feasibility and have practical value.
Mathematical Simulation and Numerical Computation of the Temperature Profiles in the Peripherals of Human Brain during the Tepid Sponge Treatment to Fever
Authors: Aijaz Mir , Dar Javid Gani , Almanjahie Ibrahim M. , Sajjad Irsa
Published: January 2022

Background. Fever is one of the frequently occurring diseases in human beings, and the body is said to have befallen in fever if the arterial or internal body temperature rises to 38°C. The patient who suffers from fever is either given paracetamol or tepid sponging or both. Objective. This paper is aimed at studying the effects of the tepid sponge in normalizing the high temperature of the human body during fever. Among the various available methods for tepid sponging, the impact of holding a cool wet cloth on the forehead for reducing the fever is analyzed and pictured graphically. Method. For analyzing the effects of tepid sponge on the temperature distribution of the domain consisting of scalp, skull, and cerebrospinal fluid (CSF), a cool wet cloth is brought in contact with the skin allowing the heat to transfer from the brain to the wet cloth through these layers. The heat transfer in living biological tissues is different from ordinary heat transfer in other nonliving materials. Therefore, a model based on the bioheat equation has been constructed. The model has been solved by numerical methods for both steady- and unsteady-state cases. The domain, which consists of the scalp, skull, and CSF layers of the human head, has been discretized into four equal parts along the axes of the three-dimensional coordinate system. The forward difference and forward time centered space approximations were employed for numerical temperature distribution results at the nodal points. Results. The effects of tepid sponge in reducing the body temperature with fever at 38°C, 39.5°C, and 41°C have been numerically calculated, and the results were pictured graphically. For transient cases, the corresponding calculations have been carried out at times

t
=
2
 
minutes

, 4 minutes, and 6 minutes. Conclusion. Among all the available remedies to fever, tepid sponging has shown a significant effect in controlling fever.
Internet Football Training Teaching Data Analysis Based on an Embedded Sensor Network
Authors: Xue Ming , Liu Zhenfeng
Published: January 2022

Football is recognized as the “first sport” with the largest number of players and the highest concentration in the world, and it also plays a pivotal role in the development of Chinese sports. Whether football can be fully developed is the key to reflecting the strength of the national sports industry. Based on the embedded sensor network, this article analyzes the internet football training and teaching data. This article is aimed at analyzing the effects of the combination of embedded sensor networks and various indexes of football sports and at making full use of this technology to provide guidance for the update of football players’ training concepts. The article first analyzes the parameters of the embedded sensor and analyzes the specific details of the football players’ actions, such as skill, strength, and continuity of the action, based on the structure of the captured image. Then, this article selects 40 football players from a certain place and analyzes their concepts of football sports competition education and training. With the help of sensor network technology to carry out experimental comparison, this article focuses on the analysis of the experimental group and the control group, respectively, around movement stretching and dynamic integration, athletes’ training willingness, etc. The experimental training data shows that the experimental group has more advantages in training results whether it is muscle activation or nerve activation. In terms of nerve activation, the maximum parameter of the experimental group members was 8.74, and that of the control group was only 7.03. The gap between the two shows that through the application of embedded sensor network technology, Internet football training and teaching can provide a significant auxiliary role for the development of football players in all aspects.
The Effects of Calcium Fertilizer Sprays during Fruit Development Stage on Pineapple Fruit Quality under Humid Tropical Climate
Authors: Loekito Supriyono , Afandi  , Afandi Auliana , Nishimura Naomasa , Koyama Hiroyuki , Senge Masateru
Published: January 2022

Low calcium content in pineapple could decrease its quality, such as fruit translucency (electrolyte leakage), bruises (fruit firmness), and the other fruit quality standards. The purpose of the current study was to assess the effect of different sprays of calcium (Ca) fertilizer sources during the fruit development stage on the overall fruit quality. Four sources of calcium, chelated calcium, calcium nitrate (Ca(NO3)2), calcium chloride (CaCl2), each in 75 kg ha−1, and calcium boron (calcibor) of 10 L ha−1 mixed with 2000 L water, were directly sprayed onto individual fruit and crown, 75, 85, 95, and 105 days after forced flowering induction (forcing). The Smooth Cayenne “MD-2” pineapple cultivar was utilized for the experiment in a randomized complete block design with four replications and conducted at two different times. Fruit quality analyses were carried out on the harvested fruits 140 days after forcing. The application of calcium sprays did not have significant effects on fruit

p
H

, total soluble solids, total acidity, fruit firmness, and the content of sucrose and vitamin C. There was a different response of calcium spray in the first and second trials on the content of glucose, fructose, β-carotene, Ca, and Mg, probably due to climate condition. All treatments with calcium sprays reduced the fructose and glucose contents in the first trial and β-carotene content in the second trial. Calcium chloride and calcibor increased Ca and decreased electrolyte leakage significantly than the other treatments. The scanning electron microscope analysis revealed that CaCl2 sprays generated greater turgor and more rigidity in the pineapple cell wall. The result showed that the application of CaCl2 and calcibor sprays could decrease electrolyte leakage incidence in pineapple with any potential to reduce glucose, fructose, and β-carotene without influencing other fruit qualities significantly.
Data-Driven Learning Teaching Model of College English Based on Mega Data Analysis
Authors: Zhang Jie
Published: January 2022

With the arrival of the mega data era, CET has developed a new teaching model based on mega data. This teaching requirement is met by a data-driven model based on mega data. By applying it to CET, students will be guided to explore and discover language rules and pragmatic features through quantitative analysis of data-driven technology, which will help compensate for the disadvantages of traditional English teaching and improve students’ autonomous learning ability. The concept of data-driven language learning is introduced into teaching in this paper. Corpus is tried to stimulate students’ autonomous learning in the teaching process, and the independent learning model of students is further improved in the teaching reform, based on educational theories of corpus linguistics and second language acquisition linguistics. Students’ scores have improved, particularly in English listening, according to the findings. The data-driven CET-4 model improves students’ learning ability and interest, as well as their ability to think creatively and critically.
Two-to-Two Processes at an Electron-Muon Collider
Authors: Bouzas Antonio O. , Larios F.
Published: January 2022

Based on a recent proposal to build an electron-muon collider, we study two-to-two production processes

e

−

μ

+

⟶
f

f
¯

,

γ
γ

that originate from dimension 6 and 8 operators. We compare the sensitivity to those effective couplings obtained at the collider with that of low energy measurements of

μ
⟶
e
γ

,

μ
⟶
e

e
¯

e

, and

μ
⟶
e

conversion that have recently been reported in the literature. Whereas for the production of first family fermions, the sensitivity of the collider processes is much weaker; for the second and third family fermions, it is similar or stronger than that of low-energy processes. In the case of

e

−

μ

+

⟶
γ
γ

, the sensitivity to a dimension 8 contact operator turns out to be the strongest in comparison.
Antibacterial and Dye Degradation Activity of Green Synthesized Iron Nanoparticles
Authors: Roy Arpita , Singh Vishwajeet , Sharma Sukriti , Ali Daoud , Azad Abul Kalam , Kumar Gokhlesh , Emran Talha Bin
Published: January 2022

Nanoparticles have a wide range of applications in various fields such as cosmetics, pharmaceuticals, and agrochemicals. Synthesis of nanoparticles using plant extract is a very efficient, cost‐effective, useful, and environmentally friendly method. A plant extract acts as a reducing agent in the formation of nanoparticles. Catharanthus roseus is one of the potential plants for biosynthesis of nanoparticles due to its easy availability. In the present study, the Catharanthus roseus plant extract was used to synthesize iron nanoparticles. UV‐vis spectroscopy, DLS, and FTIR were performed for characterization of synthesized nanoparticles. Further antibacterial and dye degrading properties of synthesized iron nanoparticles have been investigated. It was found that Catharanthus roseus‐synthesized iron nanoparticles showed antibacterial activity against E. coli and dye degradation activity against methyl orange dye.
Anthelmintic Drug Resistance of Gastrointestinal Nematodes of Naturally Infected Goats in Haramaya, Ethiopia
Authors: Wondimu Anteneh , Bayu Yehualashet
Published: January 2022

Gastrointestinal parasites and their anthelmintic resistance are major constraints to goat production in Ethiopia. Experimental investigation by faecal egg count reduction test (FECRT) and larval cultures were used to assess the occurrence of anthelmintic resistance in naturally infected goats with gastrointestinal nematodes (GIN) in Haramaya, Ethiopia. One hundred goats with a minimum of 150 eggs per gram (EPG) count were selected and randomly divided into five groups, 20 goats in each group, four treated and one untreated group. The result of the faecal egg count reduction test percentage (FECRT%) and the lower 95% confidence limit showed the presence of anthelmintic resistance for all tested drugs except tetramisole. FECRT% and lower 95% confidence limit were 69.9% and 36.9 for albendazole, 84.3% and 66.1 for tetraclozan, 95.7% and 87.4 for tetramisole, and 71.1% and 38.2 for ivermectin, respectively. Trichostrongylus, Teladorsagia, and Haemonchus showed anthelmintic resistance for tested drugs. Coproculture from different treatment groups revealed Trichostrongylus (69.2% in ivermectin and 59.6% in albendazole) were the predominant nematode followed by Teladorsagia (21.9% in albendazole and 14.7% in ivermectin). In tetraclozan treatment group, Trichostrongylus (42%) and Teladorsagia (41.3%) were comparable, followed by Haemonchus (13%). In group treated with tetramisole, Teladorsagia (54.3%) were the most frequently detected nematode followed by Trichostrongylus (25.7%) and Haemonchus (11.4%). Therefore, this study demonstrated the presence of multidrug resistant nematodes that may limit the productivity of goats. Moreover, further studies covering wider areas of Ethiopia and mechanisms of nematode resistance need to be studied in the future.
Adrenal Myelolipoma Masquerading as an Adrenal Malignancy
Authors: Robinson Davida A. , Kemeny Margaret , Muchinyi Juliana E. , Yasin Madiha , Montes Nilda I. , Tuli Sandeep , Jaiswal Radhika , Carter Amanda , Derezil Michal-Ann , Jang Hanna , Reich David
Published: January 2022

An adrenal myelolipoma presenting with suspicious features may pose a diagnostic challenge to surgeons and endocrinologists. In this case report of an adult patient with undiagnosed congenital adrenal hyperplasia presenting with bilateral adrenal masses, we review his radiographic and clinical findings which were highly suspicious for adrenal malignancy. Features of adrenal myelolipoma that may resemble malignant lesions are reviewed. This case report highlights important features of adrenal myelolipoma that the surgeon and endocrinologist should be aware of. The importance of avoiding overtreating adrenal myelolipomas presenting as tumors of uncertain malignant potential is crucial.
Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology
Authors: Zhou Shuqin , Bi Juan , Zhao Wei , Zhao Jian , Wan Honghong , Wang Sheng
Published: January 2022

This is a study that is based on network pharmacology, focusing on the pharmacological mechanism of fentanyl in easing pain. Through PPI, GO, and KEGG network pharmacology, the potential pharmacological mechanism of fentanyl was studied. This study compared and analyzed the overlap between the target genes of the active ingredient of fentanyl and the pain treatment target genes. After constructing PPI based on fentanyl, the GO and KEDD pathways were analyzed for enrichment. On the basis of overlapping genes, we constructed the PPI, GO, and KEGG, and analysis showed that the mechanism was likely to be related to some biological process. This study preliminarily identified the important proteins and metabolic pathways related to fentanyl in pain treatment and expected to provide new evidence and research ideas for the use of fentanyl, enhancing effects and alleviating adverse drug reactions.
Application of Samarium- and Terbium-Sensitized Luminescence via a Multivariate-Based Approach for the Determination of Orbifloxacin
Authors: Al-Hashimi Nessreen , El-Shafie Ahmed S. , Jumaa Asmaa , El-Azazy Marwa
Published: January 2022

A lanthanide-based optical sensor has been developed for the sensitive and reliable spectrofluorometric determination of the fluoroquinolone antibiotic orbifloxacin (ORLX). Reaction of ORLX and two lanthanide metal ions, Sm(III) and Tb(III), in aqueous buffered solution produced highly fluorescent complexes. Plackett–Burman design (PBD) was used to explore the impact of four factors, pH, temperature (Temp), contact time (CT), and metal volume (MV), on the fluorescence intensity (FI) of the produced complexes. The obtained data showed that pH was the most significant variable. A blend of pH = 5.0, MV = 2.0 mL, T = 25°C, and CT = 10 min was used to achieve the maximum FI. FT-IR and Raman analyses were performed for the crystals of the as-prepared complexes. Obtained data showed shifting in most of the absorption bands, confirming the complexation of ORLX with both metal ions. Job’s method showed that the stoichiometry for the reaction of ORLX with Sm(III) and Tb(III) was 1 : 1. The proposed method was validated following the ICH guidelines. Injection formulation was analyzed successfully with the developed method with high recovery (99.42–100.91%). The detection and quantification limits were 0.987 and 3.289 ng/mL for the ORLX-Sm(III) complex and 1.020 and 3.399 ng/mL for the ORLX-Tb(III) complex, respectively.
Foundation Reinforcement Method of Railway Logistics Center Station Based on Deformation Control and Thermodynamics
Authors: Peng Zhiping , Liu Xiumiao , Zhao Kuangying
Published: January 2022

In view of the existing methods of foundation reinforcement considering the deformation of the site and the poor effect of the foundation reinforcement, a method of the foundation reinforcement of a railway logistics center station based on deformation control and thermodynamics is proposed. The basic principle of thermodynamics is introduced, and the influence of temperature on the soil properties of foundation is analyzed. Based on the analysis of the engineering geology and hydrogeological conditions of the site, the deformation of the site is calculated, the bearing capacity of the surrounding environment of the foundation pit to the additional deformation is analyzed, and the reinforcement mechanism of the yard foundation in the railway logistics center is proposed to realize the reinforcement of the yard foundation. The experimental results show that this method can use the least tamping pit filler under the same conditions, with a minimum of 7.34 m3 to realize foundation reinforcement, the maximum ground settlement is only 5.98 mm, and the maximum lateral displacement of pile top is only 6 mm, which can meet the actual requirements and has high practical value.
Diet-Derived Circulating Antioxidants and Risk of Stroke: A Mendelian Randomization Study
Authors: Miao Rujia , Li Jing , Meng Changjiang , Li Yalan , Tang Haibo , Wang Jie , Deng Peizhi , Lu Yao
Published: January 2022

Background. Oxidative stress is crucial in stroke pathogenesis. Many cohort-based studies suggested that the intake of exogenous antioxidants originated from food may prevent stroke. However, the corresponding randomized controlled trials did not show diet-derived antioxidants have a protective effect on stroke. Objectives. To examine the association of genetically proxied diet-derived antioxidants with stroke risk using Mendelian randomization. Methods. We performed a two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of diet-derived antioxidants on stroke risk. For exposure data, we extracted genetic variants as instrumental variables (IVs) that are strongly associated with frequently used diet-derived antioxidants, including vitamin C, vitamin E (α-tocopherol, γ-tocopherol), carotene, retinol, zinc, and selenium, from a large-scale genome-wide association study (GWAS). We obtained IVs’ corresponding effect estimates on the risk of total stroke and ischemic stroke from a GWAS meta-analysis with 40,585 cases and 406,111 controls. Finally, we applied five types of Mendelian randomization analysis to obtain preliminary MR results and performed four three kinds of sensitivity analysis to verify them. Results. According to the primary MR estimations and further sensitivity analyses, we established two robust associations after Bonferroni correction: genetically proxied circulating γ-tocopherol was causally associated with total stroke [

odds
 
ratio
 

OR

=
0.68

, 95% confidence interval (CI) (0.52-0.88),

p
=
3.78
E
−
03

] and ischemic stroke [

OR
=
0.66

, 95% CI (0.51-0.86),

p
=
2.34
E
−
03

]. There was no evidence to support the causal effect of other diet-derived antioxidants on the risk of total stroke and ischemic stroke. Conclusion. Our study revealed a protective impact of genetic susceptibility to high circulating γ-tocopherol levels on stroke risk, providing new information on the potential therapeutic targets for primary stroke prevention.
High-Dynamic Dance Motion Recognition Method Based on Video Visual Analysis
Authors: Luo Wanshu , Ning Bin
Published: January 2022

In the field of computer vision, high-dynamic dance motion recognition is a difficult problem to solve. Its goal is to recognize human motion by analyzing video data using image processing and classification recognition technology. Video multifeature fusion has sparked a surge in research in a variety of fields. Several pixel points that can be distinguished and displayed in several adjacent images that can reflect their characteristics are referred to as multifeature fusion. It is responsible for a significant portion of the similarity results between the two video segments. Motion recognition relies heavily on video multifeature fusion, which has a direct impact on the robustness and accuracy of recognition results. The directional gradient histogram features, optical flow direction histogram features, and audio features extracted from dance video are used to characterize dance movements after all of the characteristics of dance movements have been considered. This paper focuses on the high-dynamic dance action recognition method based on video multifeature fusion, which aims to combine high-dynamic dance action recognition and video multifeature fusion.
Effect of Comprehensive Nursing Intervention on the Effect of CT-Guided Intravenous Thrombolysis in Acute Cerebral Infarction
Authors: Sun Zhenzhong , Jiang Hong , Chen Cuiqing , Fan Yanxia
Published: January 2022

Objective. To investigate the effect of comprehensive nursing intervention on the effect of CT-guided intravenous thrombolytic therapy for acute cerebral infarction. Methods. 99 patients with acute cerebral infarction in the internal carotid artery system who were hospitalized in our department from December 2019 to December 2020 with an onset of 3–9 h were selected and randomly divided into two groups. All patients underwent multimode CT examinations and received rt-PA thrombolytic therapy. 52 patients with conventional care were included in the control group, and 47 patients with comprehensive nursing intervention were included in the observation group. The influence characteristics, Barthel score, serum MMP-9 level, and NIHSS score were compared between the two groups. Results. After the comprehensive nursing intervention, the total efficiency, total satisfaction, psychological status, and Barthel score of the observation group were significantly higher than those of the control group (

P
<
0.05

). The serum MMP-9 level and NIHSS score were significantly lower than those of the control group (

P
<
0.05

). Conclusion. The use of comprehensive nursing interventions in the CT-guided intravenous thrombolysis treatment of ACI patients reduced the degree of neurological impairment, improved the therapeutic effect, increased nursing satisfaction, and enabled better control of the condition of patients with cerebral infarction, which is worth promoting research.
Design and Implementation of Automatic Water Spraying System for Solar Photovoltaic Module
Authors: Ashok Kumar L. , Indragandhi V. , Teekaraman Yuvaraja , Kuppusamy Ramya , Radhakrishnan Arun
Published: January 2022

Photovoltaic (PV) cell has a characteristic of decrease in power beyond a certain temperature. This decrease in power is due to a drop in the open circuit cell voltage. This decreases the efficiency of the PV cell. The objective of this research is to increase the efficiency of PV cells by reducing the PV cell temperature and reflection loss. The cell temperature and reflection loss can be reduced by spraying water over the PV cells. On spraying water over the USP36, 24V PV module, the power is found to be increased. The test result shows a 1V to 2V increase in voltage, with an efficiency increment of 1% to 1.27%. The test results of USP37 show the voltage increase of 1.2 V to 2.1 V in the PV module voltage. Due to the increase in voltage, efficiency increment of 1.29% is observed. The efficiency of USP36 with water spraying is more than the efficiency of USP37 without water spraying. In the PV power systems, an average increase in efficiency of 0.5% is observed.
Separation of Some Anionic Dyes Using Reverse Micelles of CTAB and SDS as Efficient Surfactants Adsorbents from Aqueous Medium
Authors: El Refay Heba M. , Badawy Nagwa , Hamada Amina , Hassen El Shimaa
Published: January 2022

Extractive removal of anionic dyes, namely, Color Index (CI) Reactive Blue 222 and Reactive Yellow 145, using reverse micelles based on liquid-liquid extraction (LLE) was carried out from aqueous solutions using different anionic and cationic surfactants (e.g., sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide (CTAB), resp.), which dissolved in ethyl acetate as solvent. The reverse micelle principal acts on the dye encapsulated in the solvent in an aqueous micropool. The experiments were carried out by mixing in a simple mixer a given amount of dyes and surfactants dissolved in a solvent in an aqueous process. Due to gravity, the dye is separated from water after the solvent phase is separated from the aqueous phase, including dye encapsulated in reverse micelles. Under various experimental conditions, extraction efficiency was studied, including solution pH, extraction time, initial dye concentration, extractant concentration, temperature, stripping agent, and solvent reusability. Dyes extracted were stripped quantitatively with NaOH solution. Recovery of the solvent and the reuse of dyes and surfactants after extraction of dye molecules from reverse micelles surfactant core considered are very important from an economic point of view. The optimized conditions were 7 ± 0.2 solution pH, 9 × 10−2 mol/L extractant concentration, 1M NaOH stripping agent concentration, 60 min extraction time, 6 × 10−5 mol/L dye concentration, and 1 : 1 aqueous to organic (A/O) ratio. 87–93% of dyes were extracted at experimental optimum conditions.
Global Characteristics and Trends in Research on Ferroptosis: A Data-Driven Bibliometric Study
Authors: Dong Xueting , Tan Yaochong , Zhuang Donglin , Hu Tingting , Zhao Mingyi
Published: January 2022

Ferroptosis, an iron-dependent form of regulated cell death, has drawn an increasing amount of attention since it was first mentioned in 2012 and is found to play a significant role in the treatment of certain diseases. Our study is aimed at analysing the scientific output of ferroptosis research and at driving future research into novel publications. Publications focused on ferroptosis were retrieved from the SCI-EXPANDED database of the Web of Science Core Collection and were screened according to inclusion criteria. CiteSpace V and Microsoft Excel 2016 were used to evaluate and visualize the results, including generating network maps and analysing annual publications, country, category, references and cocited references, and keywords. As of October 1, 2021, a total of 1690 original articles related to ferroptosis were included, and the overall trend of the number of publications rapidly increased. Among the common categories in the field of ferroptosis, the most common category was biochemistry and molecular biology. Worldwide, China and the United States were the leading countries for research production. The retrieved 1690 publications received 44,650 citations, with an average of 26.42 citations per paper (October 1, 2021). By citation analysis, Scott J Dixon’s article in 2012 was the most symbolic reference and the earliest publication in the field of ferroptosis, with the highest citation rate (2709 times). Among the most common keywords, most were related to the mechanisms and regulatory networks of ferroptosis. Furthermore, with accumulating evidence demonstrating the role of ferroptosis in cancers and other diseases, inducing ferroptosis in clinical treatment is becoming a new research focus that should be closely monitored.
Application of DNA‐Binding Protein Prediction Based on Graph Convolutional Network and Contact Map
Authors: Lu Weizhong , Zhou Nan , Ding Yijie , Wu Hongjie , Zhang Yu , Fu Qiming , Li Haiou
Published: January 2022

DNA contains the genetic information for the synthesis of proteins and RNA, and it is an indispensable substance in living organisms. DNA‐binding proteins are an enzyme, which can bind with DNA to produce complex proteins, and play an important role in the functions of a variety of biological molecules. With the continuous development of deep learning, the introduction of deep learning into DNA‐binding proteins for prediction is conducive to improving the speed and accuracy of DNA‐binding protein recognition. In this study, the features and structures of proteins were used to obtain their representations through graph convolutional networks. A protein prediction model based on graph convolutional network and contact map was proposed. The method had some advantages by testing various indexes of PDB14189 and PDB2272 on the benchmark dataset.
Time-like Ruled Surface in One-Parameter Hyperbolic Dual Spherical Motions
Authors: Naghi Monia F. , Abdel-Baky Rashad A. , Mofarreh Fatemah
Published: January 2022

In this work, we introduce a time-like ruled surface in one-parameter hyperbolic dual spherical motions. This provides the ability to derive some formulae of surface theory into line spaces. Then, a time-like Plücker conoid associated with the motion has been obtained, and its kinematic geometry is researched in detail. Consequently, a characterization for a time-like ruled surface to be a constant Disteli-axis is derived and investigated in detail. At last, we have discussed some special cases which lead to some special time-like ruled surfaces such as the time-like helicoids, Lorentzian sphere, and time-like cone.
Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study
Authors: Lee Jin , Park Su Bum , Kim Hyung Wook , Lee Hong Sub , Jee Sam Ryong , Lee Jong Hun , Kim Tae Oh
Published: January 2022

Background. A substantial percentage of patients with ulcerative colitis (UC) have irritable bowel syndrome- (IBS-) like symptoms despite adequate treatment and endoscopic remission. In this study, we evaluated the clinical efficacy of probiotic therapy for residual IBS-like symptoms in patients with UC in endoscopic remission. Methods. We conducted a multicenter, observational study between April 2018 and December 2020 across two university hospitals in Korea. Patients with UC whose IBS-like symptoms persisted during endoscopic remission were included in this study. Endoscopic remission was defined as a Mayo endoscopic

score
≤
1

, and IBS-like symptoms were defined as those meeting the ROME-IV diagnostic criteria. A Biotop capsule® (Lactobacillus acidophilus, 75 mg; Clostridium butyricum TO-A, 25 mg; Bacillus mesentericus TO-A, 25 mg; and Streptococcus faecalis T-110, 5 mg) was administered three times daily for one month. All patients completed bowel-related symptom questionnaires and short inflammatory bowel disease questionnaires (SIBDQs) at the start and end of the 4-week treatment period. Results. A total of 43 patients were enrolled and analyzed. Statistically significant improvements from baseline were observed at the end of the 4-week treatment. The total SIBDQ score improved from 50.6 to 53.6 (

P
=
0.005

). SIBDQ scores of bowel function (

P
=
0.018

), systemic function (

P
=
0.040

), and social function (

P
=
0.005

) improved. Stool frequency and Bristol stool scale scores improved after probiotic therapy (

P
<
0.05

). Conclusion. This study showed that probiotic administration improved bowel-related symptoms and quality of life in patients with UC whose IBS-like symptoms persisted during endoscopic remission. As this is an observational study and has no placebo-controlled arm, further prospective randomized controlled trials are needed to confirm these results.
LncRNA OIP5-AS1 Signatures as a Biomarker of Gestational Diabetes Mellitus and a Regulator on Trophoblast Cells
Authors: Li Yanmei , Liu Lei
Published: January 2022

Objectives: Gestational diabetes mellitus (GDM) is a common disorder in pregnant women. Long noncoding RNA (lncRNA) is a fundamental mediator in the pathogenesis of GDM. The study aimed to detect the clinical importance of lncRNA OIP5-AS1 and its underlying regulation on trophoblast cells. Design: The expression of OIP5-AS1 and miR-137-3p was assessed by the quantitative real-time PCR technique. The prognostic effect of OIP5-AS1 was analyzed by the receiver operating characteristic curve. The influences of OIP5-AS1 on cells were indicated by cell counting kit-8, transwell experiments, and flow cytometry. Luciferase activity assay was used to identify the target relationships among OIP5-AS1, miR-137-3p, and EZH2. Participants: A total of 75 pregnant women with GDM who were treated in the Dongying People’s Hospital were selected as the GDM group. Besides, 72 pregnant women with non-GDM who underwent physical examination in the same hospital were selected as the control group. Results: Decreased expression of OIP5-AS1 was confirmed in GDM patients, and the level of OIP5-AS1 could be used as a basis for evaluating GDM patients. Upregulation of OIP5-AS1 ameliorated the viability, migration, invasion, and apoptosis of HG-stimulated HTR-8/SVneo cells by sponging miR-137-3p. EZH2 was a direct target of miR-137-3p. Conclusions: OIP5-AS1 level decreased in women with GDM. OIP5-AS1 appeared to help separating GDM patients from healthy pregnant women. The OIP5-AS1/miR-137-3p/EZH2 pathway could exert its function on HG-induced HTR-8/SVneo models.
Quality of Life after Rectal Cancer Resection Comparing Anterior Resection, Abdominoperineal Resection, and Complicated Cases
Authors: Scheele Jan , Lemke Johannes , Wittau Mathias , Sander Silvia , Henne-Bruns Doris , Kornmann Marko
Published: January 2022

Introduction: Compared to abdominoperineal resection (APR), sphincter preservation using low anterior resection (AR) for rectal cancer (RC) implies the risk of impaired functional outcome and postoperative complications associated with a persistent or additionally required ostomy. The aim of our study was to compare quality of life (QoL) after AR and APR with a special separate analysis of AR patients with a stoma. Methods: QoL of 84 APR, 356 AR, and 29 AR patients with complications and an additional stoma, termed converted therapy (COT) patients, was compared with regard to groups and effect of radiotherapy (RT). All patients received rectal resection between 1998 and 2013, and 47% of the patients had RT. QoL was assessed using extended EORTC QLQ-C30 and -CR38 questionnaires. Results: Questionnaires from 57 APR, 165 AR, and 25 COT patients alive were evaluated after a median time of 4 years after surgery. Global health status was equally high in AR and APR patients (score: 67), whereas COT patients turned out with a significantly lower score of 50 (p = 0.007). Compared to APR and COT, AR patients revealed less symptoms and higher functionality, especially for physical, role, and social functioning (p < 0.001). The reduction of QoL instances was significant in the COT group and in all patients treated by RT. Conclusion: QoL after RC resection may be further improved by avoiding additionally required ostomy after AR but also RT by a better individual selection of qualified patients. Qualification parameters urgently need to be defined by prospective studies.
Angelica acutiloba Exerts Antihypertensive Effect and Improves Insulin Resistance in Spontaneously Hypertensive Rats Fed with a High-Fat Diet
Authors: Watanabe Yusuke , Nessa Naseratun , Toba Hiroe , Kobara Miyuki , Nakata Tetsuo
Published: January 2022

Introduction: Angelica acutiloba is one of the crude drugs used in Chinese herbal medicine, and its intake is expected to improve metabolic syndrome-associated disorders. Here, we examined the effects of A. acutiloba extract (AAE) on hypertension and insulin resistance induced by the treatment of high-fat diet (HFD) to spontaneously hypertensive rats (SHRs). Then, we investigated the mechanisms associated with the effects of AAE. Methods: AAE was administered to HFD-fed SHRs. Systolic blood pressure (SBP), sympathetic nerve activity, hypothalamic angiotensin-converting enzyme (ACE) activity, blood glucose level, plasma insulin concentration, visceral fat mass, and gene expression of tumor necrosis factor-alpha (TNF-α) in the visceral fat were evaluated. Results: AAE reduced the increases in SBP and hypothalamic ACE activity observed in the HFD-fed SHRs, whereas the suppressive effect on sympathetic nerve activity was slight. Environmental stress-induced pressure and sympathetic overactivity were suppressed by the treatment of AAE. It also decreased the increase in the blood glucose level, plasma insulin concentration, homeostasis model assessment for the insulin resistance, and TNF-α gene expression in the visceral fat, but not the increase in the visceral fat mass. Conclusion: AAE has an antihypertensive effect, suppresses stress-induced hypertension, and improves insulin resistance in HFD-fed SHRs. The suppression of brain ACE activity, sympathetic nerve activity, and inflammation are partly involved in the effects of AAE.
Body Composition of Preterm Infants following Rapid Transition to Enteral Feeding
Authors: Wiechers Cornelia , Avellina Vanessa , Luger Beate , Böckmann Katrin , Minarski Michaela , Maas Christoph , Bernhard Wolfgang , Poets Christian F. , Franz Axel R.
Published: January 2022

Objective: This study aimed to evaluate body composition at the time of hospital discharge in very preterm infants following rapid transition to full enteral feeding. Study Design: We conducted a prospective, observational, cross-sectional study and included 105 preterm infants <32 gestational age or birth weight <1,500 g, born between April 2015 and December 2020, following rapid transition to full enteral feeding (≥140 mL/kg/day). Fat mass/total body mass (BF%) and fat-free mass (FFM) were measured at the time of hospital discharge using air displacement plethysmography. Results: Median and interquartile range (Q1–Q3) of gestational age at birth (GA) was 27.3 (26.1–28.7) weeks and birth weight 845 (687–990) g. Time to reach full enteral feeding was 5 (5–7) days. At 37.6 weeks (36.1–39.0) postmenstrual age (PMA), BF% was 17.0% (14.9–19.8) and FFM 2,161 g (1,966–2,432). BF% was not associated with GA, and not different between small and appropriate for gestational age infants. FFM was significantly lower in infants born small for gestational age. Conclusions: Following rapid transition to full enteral feeding, FFM and BF% at discharge were similar to other preterm populations. BF% and FFM were not associated with GA at birth but with PMA at measurement. FFM was lower and BF% higher compared to term infants at birth, suggesting diminished parenchymal growth in preterm infants. Continued monitoring of body composition, metabolic health, and neurological development is needed to study long-term effects.
Inflammation and Microcalcification: A Never-Ending Vicious Cycle in Atherosclerosis?
Authors: Kawtharany Lynn , Bessueille Laurence , Issa Hawraa , Hamade Eva , Zibara Kazem , Magne David
Published: January 2022

Inflammatory cells and cytokines are known for long to worsen the development of atherosclerotic plaques in mice, and intense efforts are today devoted to develop anti-inflammatory therapeutic strategies to slow down plaque development. Increasing data indicate that plaque inflammation is intimately associated with microcalcifications, which exert harmful effects eventually culminating with plaque rupture. In this review article, we will first introduce microcalcification location, detection, and effects in atherosclerotic plaques. Then, we will present the numerous data suggesting that inflammatory cells and molecules are responsible for the formation of microcalcifications and the articles showing that microcalcifications stimulate macrophages and smooth muscle cells to produce more pro-inflammatory cytokines. Finally, we will discuss the possibility that microcalcifications might stimulate smooth muscle cells to produce larger and more stable calcifications to stabilize plaques, to exit the vicious cycle associating inflammation and microcalcification in atherosclerotic plaques.
MDS/MPN-Unclassifiable with t(X;17)(q28;q21) and KANSL1-MTCP1/CMC4 Fusion Gene
Authors: Molony Peter , Smith Adam C. , Selvarajah Shamini , Sakhdari Ali
Published: January 2022

Myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U) is a poorly characterized entity among overlap myeloid syndromes. Recent studies have shown heterogeneous mutational profiles in this group being able to subclassify them into entities closely related to the more well-established disorders under the umbrella term of the MDS/MPN group. Recurrent cytogenetic alterations are, nonetheless, rare in MDS/MPN-U. Here, for the first time, we report a case of MDS/MPN-U with a t(X;17)(q28;q21) chromosomal rearrangement leading to the KANSL1-MTCP1 fusion gene.
MicroRNA-494-3p Exacerbates Renal Epithelial Cell Dysfunction by Targeting SOCS6 under High Glucose Treatment
Authors: Xue Xianjun , Liu Minjie , Wang Yulu , Yang Yanlei , Li Zhiping , Shi Ruifang , Miao Yueting
Published: January 2022

Background: Diabetic nephropathy is a common complication of the kidneys induced by diabetes and is the main cause of end-stage renal disease. MicroRNA-494-3p was reported to be upregulated in renal tissues collected from db/db mice, but its specific role in diabetic nephropathy was still unclear. This study aimed to explore the effect of miR-494-3p on renal fibrosis using an in vitro cell model of diabetic nephropathy. Methods: After human renal tubular epithelial cells (HK-2) were treated with high glucose (HG), the viability and apoptosis of cells were examined by CCK-8 assays and flow cytometry analyses. Additionally, protein levels of fibronectin, collagen I, collagen III, collagen IV, and epithelial-mesenchymal transition (EMT) markers in HG-induced HK-2 cells were quantified by Western blotting. miR-494-3p expression in HK-2 cells was detected by reverse-transcription quantitative polymerase chain reaction. The binding relation between miR-494-3p and the messenger RNA suppressor of cytokine signaling 6 (SOCS6) was detected by luciferase reporter assays. Results: HG reduced cell viability and enhanced cell apoptosis in a time- or concentration-dependent manner. Additionally, HG induced collagen accumulation and triggered the EMT process. miR-494-3p was upregulated in HG-treated HK-2 cells. miR-494-3p inhibition alleviated HG-induced cell dysfunction. Mechanistically, miR-494-3p bound with SOCS6 and negatively regulated SOCS6 expression. Moreover, silencing SOCS6 rescued the suppressive effect of miR-499-5p inhibition on HG-induced cell dysfunction. Conclusion: miR-494-3p aggravates renal fibrosis, EMT process, and cell apoptosis by targeting SOCS6, suggesting that the miR-494-3p/SOCS6 axis may become a potential strategy for the treatment of diabetic nephropathy.
O PACTO SOBRE O PAPEL DO JORNALISMO NO BALANÇO GERAL SP: UMA ANÁLISE SOB O PONTO DE VISTA DOS MODOS DE ENDEREÇAMENTO
Authors: Paiva Gustavo Pereira de , Kruger Jesse Xavier , Negrini Michele
Published: January 2022

Os modos de endereçamento são uma teoria que surgiu na análise fílmica e que foi adaptada para análise de programas televisivos. Os telejornais aparecem como um interessante objeto de estudo para se utilizar a supracitada teoria. Este artigo visa analisar o telejornal Balanço Geral SP, que vai ao ar pela Rede Record, acerca dos modos de endereçamento, com ênfase no pacto sobre o papel do jornalismo. Vamos tomar as perspectivas de Gomes (2007) sobre os modos de endereçamento para dar bases ao estudo. E vamos analisar um bloco da edição do telejornal de 5 de abril de 2017.