bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the Application of Gamification as an Adjuvant Therapeutics for Nonspecific Neck Pain (Preprint)
Authors: Sun Xing , Fang Ke , Xian Yanjie , Lin Hongbo
Published: February 2023

BACKGROUND

Chronic nonspecific neck pain is hard-to-treat and highly prevalent. Gamification, by motivating patients to do exercises regularly, can help prevent the disease and make the treatment much easier. However, relevant studies are rarely seen.

OBJECTIVE

The study aims to propose a scientific framework for developing gamified motion sensing health Apps, under which it seeks to combine motion capture technology in practice to develop a gamified App for the prevention and adjuvant treatment of chronic nonspecific neck pain, and evaluate its efficacy.

METHODS

Based on Game for Health (G4H), a health theory for game design, specifications for digital health App design, and Gameflow, the game experience evaluation model, this paper proposed a framework for developing gamified motion sensing health App, GMH. Based on the GMH framework, a set of digital health gamification Apps was developed using motion capture technologies. In addition, experiments were designed to test the effects of the neck exercise of the gamified motion sensing interaction on exercise intervention under limited conditions. A total of 20 subjects participated in this study. They were divided into experimental group A and control group B, with 10 subjects in each group. Group A installed the gamification software designed to exercise. Group B only learned cervical spine health knowledge through conventional methods for four days. The subjects’ Neck Disability Index (NDI) data was collected, and so was the data such as the average steps they walk per day and heart rate before and after the test.

RESULTS

The experimental group’s overall average NDI dropped by 0.13, and the average steps they walked per day increased by 22.66% during the experiment period. The 10 subjects in the experimental group all reported positive data results under the three measurement dimensions of “perceived usability,” “perceived ease of use,” and “willingness to continue using” in the Technology Acceptance Model. Additionally, they reported that the gamification App provided was helpful to their recovery.

CONCLUSIONS

This study proposed a scientific and effective framework for developing gamified motion sensing health Apps. Under this framework, the adjuvant treatment App for chronic nonspecific neck pain named “Upright Life” produced satisfactory effects , providing a credible and innovative research case for this field.
The Multidomain Metaverse Cancer Care Digital Platform: Development and Usability Study (Preprint)
Authors: Kim Sunghak , Jung Timothy , Sohn Dae Kyung , Chae Yoon , Kim Young Ae , Kang Seung Hyun , Park Yujin , Chang Yoon Jung
Published: February 2023

BACKGROUND

As cancer treatment methods have diversified and the importance of self-management, which lowers the dependence rate on direct hospital visits, has increased, effective cancer care education and management for health professionals and patients have become necessary. The metaverse is in the spotlight as a means of digital health that allows users to engage in cancer care education and management beyond physical constraints. However, it is difficult to find a multipurpose medical metaverse that can not only be used in the field but also complements current cancer care.

OBJECTIVE

This study aimed to develop an integrated metaverse cancer care platform, Dr. Meta, and examine its usability.

METHODS

We conducted a multicenter, cross-sectional survey between November and December 2021. A descriptive analysis was performed to examine users’ experiences with Dr. Meta. In addition, a supplementary open-ended question was used to ask users for their suggestions and improvements regarding the platform.

RESULTS

Responses from 70 Korean participants (male: n=19, 27% and female: n=51, 73%) were analyzed. More than half (n=37, 54%) of the participants were satisfied with Dr. Meta; they responded that it was an interesting and immersive platform (n=50, 72%). Less than half perceived no discomfort when using Dr. Meta (n=34, 49%) and no difficulty in wearing and operating the device (n=30, 43%). Furthermore, more than half (n=50, 72%) of the participants reported that Dr. Meta would help provide non–face-to-face and noncontact services. More than half also wanted to continue using this platform in the future (n=41, 59%) and recommended it to others (n=42, 60%).

CONCLUSIONS

We developed a multidomain metaverse cancer care platform that can support both health professionals and patients in non–face-to-face cancer care. The platform was uniquely disseminated and implemented in multiple regional hospitals and showed the potential to perform successful cancer care.
Study of the Influence of Factors Determining the Results of Geophysical Surveys in Territories Contaminated with Light Non-Aqueous Phase Liquid
Authors: Mingaleva Tatiana , Shakuro Sergey , Egorov Alexey
Published: February 2023

To solve environmental problems in the search for hydrocarbon pollution, geophysics is often used. In contaminated sites, knowledge of the geological structure and hydrogeological conditions, as well as the qualitative and quantitative characteristics of pollution, is essential for risk assessment and site remediation planning. The article discusses the influence of various factors on the formation of anomalies detected by methods of shallow geophysics in the process of studying the pollution of the geological environment with oil products. The main purpose of such work is the detection, contouring and determination of the migration routes of light oil products. Understanding the processes occurring in the subsurface space during the distribution of oil products helps to correctly compare the variations in physical properties identified from geophysical data and the location of contaminated areas. One of the main factors affecting the results of geophysical surveys is the residence time of oil products in soils. The nature of geophysical anomalies changes and is a response from a complex multifactorial environment. Also, among the factors affecting the nature of geophysical anomalies, the following can be distinguished: the activity of microorganisms, redox reactions, the presence of near-surface heterogeneities, temperature, signal shredding, humidity and composition of soils in the aeration zone, fluctuations in the level of groundwater, the concentration of hydrocarbons, source of petroleum products. The paper also describes several generalized models of the distribution of hydrocarbon pollution, each of which can be used to solve the tasks set, and also be a useful tool for predicting the distribution of oil products and modeling geophysical responses from a multifactorial environment. At present, the most popular model is the “natural source zone depletion”, according to which methanogenesis plays an important role in technogenically polluted territories, as a result of which gases in anomalous concentrations are released from areas where hydrocarbons are processed by microorganisms as secondary waste products of bacteria. The authors also consider a model that is more typical for objects located on the banks of rivers or lakes. Here, the distribution model of light oil products is subdivided into three zones (donor zone, transit zone, and secondary accumulation zone), in which the processes of distribution and accumulation of oil products take place. Thus, a comprehensive study of the processes occurring in soils during oil spills and the use of theoretical models of pollutant migration can facilitate the work on the ecological study of soils contaminated with oil products.
Investigating The Mediating Role of Financial Literacy on The Relationship Between Women Entrepreneurs’ Behavioral Biases and Investment Decision Making
Authors: IRAM TAHIRA , Bilal Ahmad Raza , Ahmad Zeshan
Published: February 2023

This study investigates the theoretical link between heuristic behavioral factors and the investment decision-making of women entrepreneurs, focusing on the impor­tance of financial literacy as a potential mediator shaping prudent decision-making. We argue that women’s financial literacy is an efficient way to apply behavioral considerations in wise decision making. Using the proportionate stratified sampling method, we collect­ed data from women entrepreneurs who were formally registered in Punjab Province, Pakistan. Owing to the complex model and small sample size, the smart PLS method was applied to analyze the structural relationship between the measured and latent con­structs. The results show that overconfidence and availability heuristics have a significant positive impact on investment decisions, while financial literacy plays an essential inter­vening role between the overconfidence heuristic, availability heuristic, and investment decision-making. Our results support the execution of financial literacy awareness among women entrepreneurs to stimulate their financial decision control and give them the in­dependence to make prudent financial decisions.
The Impact of Organizational Justice on the Organizational Citizenship Behavior of Contract Workers in Indonesia: The Role of Exchange Quality and Multifocal Trust
Authors: Waskito Jati , Kussudyarsana Kussudyarsana , Imronudin Imronudin , Linansya Winda
Published: February 2023

This study aims to examine the role of the double mediation of cognition-based trust and affect-based trust, along with the quality of the exchanges (perceived organi­zational support/POS and leader-member exchange/LMX), on the influence of organi­zational justice on organizational citizenship behavior (OCB). The survey involved 182 contract lecturers from the five top Muhammadiyah universities in Indonesia. Using structural equation models, this study has succeeded in demonstrating that the quality of the individual exchanges between supervisors and subordinates (LMX and affective-based trust) successfully mediate the sources of justice from the supervisors (interactional and informational justice). The quality of the individual exchanges with organizations (cogni­tive-based trust and POS) successfully mediate the sources of the organization (procedur­al justice). Implications for the theory and practice are discussed.
The Effect of Entrepreneurial Attitudes and Individual Attributes on Entrepreneurial Activity in the context of ASEAN Member States: Evidence from Thailand and Vietnam
Authors: Wibisono Eristian , Thi Phuong Thao Hoang
Published: February 2023

This study analyzes the influence of entrepreneurial attitudes and individual at­tributes on entrepreneurial activity in two ASEAN member countries: Vietnam and Thai­land. By applying the multinomial logistics regression (MLR) analysis method, the results show that those with an entrepreneurial network, who can read business opportunities, and have skills and knowledge, have a positive and significant influence when deciding to start and invest in others’ new businesses. On the other hand, females and those with a secondary education were more likely to engage in entrepreneurial activities. The study also shows that Vietnam’s entrepreneurial attitudes and individual characteristics seem to be better, differentiating it from Thailand. The Global Entrepreneurship Monitor (GEM) data from 2017 were the most recent data available at the time of this study. However, the availability of more up-to-date data is considered necessary to enrich and expand the im­pact of future research.
Pipe Size Calculation for Water Supply
Authors: Chauhan Dinesh
Published: February 2023

Abstract: A pipe designer or engineer has to solve complex math equation for calculating the diameter of pipe to determine how much water discharge it can be handled at a particular flow velocity. This article is an effort to make the calculation of water pipe size easier. The formula and factor derived in this document can be used for pipe diameter calculation for all types of normal water supply. Like – chilled water, raw water, soft water, cooling water, hot water and hydrant water at a particular flow velocity.
Reseña:
Una mirada a la pobreza en la formación universitaria
Authors: Hernández Cuevas Francisco Iván
Published: February 2023

En un contexto global vinculado a múltiples crisis (sanitaria, ecológica, económica, social) que aumentan la incertidumbre y vulneran al tejido social más frágil, el libro Una mirada a la pobreza en la formación universitaria nos ofrece una visión precisa sobre la problemática de la pobreza en México, así como propuestas innovadoras que, a través del quehacer universitario, permiten tener una guía para el involucramiento desde la academia a esta dificultad que nos aqueja como sociedad. Tan solo en México, en 2020, más de 50 millones de habitantes se concentraban en una condición de pobreza (43.9% de la población total) de acuerdo con las cifras del Consejo Nacional de Evaluación de la Política de Desarrollo Social (CONEVAL).
Bentazona: características físico-químicas e toxicológicas de relevância ambiental
Authors: Henrique Martins Eduardo , Caroline   de   Freitas   Pantaleão Bárbara , Boschiero Hudson , Rizzo  Matiuzzo Mariana , Soncin Valdir
Published: February 2023

O bentazona é um herbicida pós-emergente que combate ervas daninhas de folhas largas através da inibição da fotossíntese. É amplamente utilizado no Brasil, principalmente nos estados da região sul do país, em culturas de arroz. É um composto solúvel em água e tem uma chance bem reduzida de ser adsorvido em solo ou sedimentos. Também, pode-se inferir que esse herbicida não se acumula em tecidos adiposos pois possui baixo valor de Kow. Além disso, ele é pouco volátil. Nesse sentido, tais características físico-químicas indicam que esse composto pode ser mais facilmente encontrado na coluna d’água. Desse modo, a partir de dados da literatura derivou-se o Critério de Potabilidade, obtendo-se a concentração máxima permitida de bentazona em água (0,540 mg/L). Os critérios para proteção da vida aquática de águas doce (0,073 mg/L) e águas salgadas (0,0073 mg/L) também foram calculados. Além disso, avaliou-se o risco para vida aquática de água doce. Na avaliação de risco, verificou-se a ocorrência de bentazona em mananciais brasileiros, que apresentou concentrações abaixo dos critérios calculados. Já numa análise sob o ponto de vista legal, verificou-se que o composto consta na lista de agrotóxicos regulamentados no CONAMA 396/2008, porém com um valor mais restritivo do que o indicado nesse estudo. Portanto, cabe uma revisão e possível atualização do valor regulamentado.
A PERCEPÇÃO DE MULHERES EM PUERPÉRIO IMEDIATO AO MOMENTO DO PARTO
Authors: Sena Aislan Ferreira , Freitas Ana Paula da Silva , Silva da Costa Antonio Werbert , AZEVEDO AMANDA PEREIRA DE , ALBUQUERQUE KEILA RODRIGUES DE
Published: February 2023

O seguinte estudo tem como objetivo analisar e descrever a percepção de puérperas acerca do momento do parto. Trata-se de um estudo de abordagem qualitativa do tipo descritivo exploratório, realizado em uma maternidade de referência pública estadual localizada no município de Teresina-PI. O estudo foi realizado com 24 mulheres no puerpério imediato, com faixa etária compreendida entre dezoito e quarenta e cinco anos, que tiveram filhos de parto normal e concordaram em participar do estudo mediante a assinatura do Termo de Consentimento Livre e Esclarecido. Para haver uma melhor compreensão quanto à discussão, foram relacionadas duas categorias a seguir: Aspectos positivos relacionados ao momento do parto e Aspectos negativos relacionados ao momento do parto. Visando manter o anonimato das participantes, foram atribuídos nomes de flores a cada uma. Observou-se que para a maioria das puérperas entrevistadas, há mais aspectos positivos do que negativos relacionados ao parto normal, tornando-se para a maioria a melhor escolha tendo uma recuperação mais rápida, retorno as atividades e independência em cuidar de seu filho.
PERFIL DAS INTOXICAÇÕES POR ANTIDEPRESSIVOS REGISTRADOS EM UM CENTRO DE INFORMAÇÃO E ASSISTÊNCIA TOXICOLÓGICA
Authors: De Lima Débora Marques , Sombra Naiane Nadylla Nobre , Malveira Sabrina Karen Medino , Rocha Anne Karoline Araújo , Bachur Tatiana Paschoalette Rodrigues
Published: February 2023

RESUMO. A grande variedade de medicamentos existentes contribui para o surgimento de problemas relacionados ao consumo indevido destas substâncias, representando um grande desafio à saúde pública tanto em países em desenvolvimento como em países desenvolvidos. No Brasil, os medicamentos correspondem à principal causa de intoxicações exógenas, ocupando a primeira posição entre os agentes tóxicos que vitimam os seres humanos. Dentre as classes de medicamentos que mais causam intoxicações destacam-se os antidepressivos, especialmente os tricíclicos (ADT), cujo uso abusivo acarreta sintomatologias graves ou mesmo risco de vida. O objetivo deste trabalho foi caracterizar as intoxicações por antidepressivos e analisar os fatores associados a estas intoxicações a partir de registros do Centro de Informação e Assistência Toxicológica (CIATOX) em Fortaleza/CE. Trata-se de um estudo transversal, descritivo e documental com abordagem quantitativa sobre as intoxicações agudas por medicamentos atendidas e notificadas pelo CIATOX de Fortaleza – CE, nos anos de 2015 e 2016. Foram analisadas 91 fichas, que compreendem a totalidade das intoxicações medicamentosas por antidepressivos registradas entre 1º de janeiro de 2015 e 31 de dezembro de 2016. A maior frequência de intoxicações ocorreu na faixa etária de 20–29 anos em ambos os sexos, sendo a maior parte por tentativa de suicídio. Associação significativa foi observada entre tentativa de suicídio e o sexo feminino no ano de 2016, fato observado em 2015 para o sexo masculino. A via oral apresenta-se como principal via de exposição intencional, sendo os antidepressivos tricíclicos os fármacos mais utilizados, por vezes associados com ansiolíticos. Faz necessário um controle maior ao acesso a estes fármacos, destacando-se o papel da equipe multiprofissional na promoção e prevenção em saúde. É imprescindível o acompanhamento adequado dos pacientes em uso destes medicamentos, bem como uma conscientização maior através de medidas de prevenção que busquem alertar os usuários sobre os riscos pertinentes ao uso inadequado destas substâncias.
Avaliação da possibilidade da utilização da ferramenta design thinking adaptada para elaborar questionário de adesão ao medicamento
Authors: Benitez Paula Takahashi , Fukushima André Rinaldi , Nicoletti Maria Aparecida
Published: February 2023

A avaliação da adesão farmacoterapêutica é um fator essencial para os resultados clínicos serem atingidos. Existem diversos métodos para avaliar a adesão do paciente à farmacoterapia, cada um deles apresenta vantagens e desvantagens e os questionários estruturados são amplamente empregados, porém, muitas vezes os pacientes, que são majoritariamente idosos, têm dificuldade em interpretar as questões, o que leva a resultados pouco confiáveis. O objetivo foi desenvolver questionário de avaliação de adesão à farmacoterapia utilizando o método de design thinking adaptado para o cuidado farmacêutico e validar sua efetividade junto aos usuários de medicamento, levantando informações que podem ser utilizadas para seu aprimoramento. A proposta da validação do Questionário de Avaliação da Adesão à Farmacoterapia por meio da ferramenta de design thinking adaptada foi bem-sucedida, os respondentes entenderam o objetivo do questionário e consideraram que as perguntas são claras e adequadas.
NÍVEL SÉRICO DE CLOZAPINA EM USUÁRIOS DE CIGARRO ELETRÔNICO
Authors: Lima Matheus Eugênio de Sousa , Lima Fernanda Eugênio de Sousa , Bachur Tatiana Paschoalette Rodrigues
Published: February 2023

A clozapina demonstrou-se um potente antipsicótico no tratamento de pacientes portadores de esquizofrenia. Ao observá-los, notou-se que existe um alto índice de tabagismo durante o seu tratamento que interfere diretamente no nível sérico desse medicamento, reduzindo sua concentração em aproximadamente um terço. Postula-se que há sua atuação na indução de uma via enzimática específica 1A2 (CYP1A2), que aumenta a metabolização desse medicamento no organismo. Sob essa ótica, os cigarros eletrônicos (CE), dispositivos a base de nicotina e outras substâncias cuja mistura é aquecida para gerar vapor, também possuem boa adesão por pacientes com transtornos psiquiátricos, dentre eles a esquizofrenia. Estudos demonstram que o mecanismo de degradação de clozapina que está presente em cigarros comuns (CC) é ausente em CE, demonstrando que esses dispositivos possuem menos interferência no tratamento em pacientes que utilizam esse psicofármaco. O objetivo deste estudo é esclarecer, com base na literatura científica vigente, efeitos nos níveis séricos de clozapina com uso de CE durante o tratamento de pacientes com esquizofrenia. A pesquisa bibliográfica foi feita por intermédio das bases de dados LILACS, MEDLINE e SCIELO, onde, inicialmente, 8 artigos foram encontrados; após serem aplicados os critérios de inclusão e exclusão, um total de seis estudos foram selecionados para compor esta revisão. Os resultados dessa revisão mostram que, com base na população apresentada, o uso de CE não possui o mesmo efeito de diminuição de nível sérico de clozapina e precisa ser levado em consideração pelo médico assistente para a garantia da segurança do usuário.
Case Report of Endometrial Polyp with Bilateral Cystic Teratoma Ovary
Authors: Kaavya M. , Singh Madhvi
Published: February 2023

Benign ovarian teratomas or dermoid cysts are the commonest germ cell tumour of ovaries, accounting for 10 to 15% of all ovarian tumours. The common age of presentation includes women's reproductive age group and post-menopausal age. These lesions can be benign, like mature teratoma or malignant, like immature teratoma, yolk sac tumour, and mixed germ cell neoplasm. These lesions are usually asymptomatic, or they can present with varying symptoms and signs. Diagnosis includes imaging and measurement of levels of tumour markers. Here we report a case of a 48-year-old woman who presented with menorrhagia for four years. The patient initially underwent dilation and curettage for similar complaints in the past, following which her cycles regularized. Later the patient was started on medications for the recurrence of symptoms. Examination revealed no abnormalities. The patient was further investigated with ultrasound and MRI pelvis and proceeded with bilateral salpingo-oopherectomy. Biopsy revealed features suggestive of benign ovarian teratoma. The patient has managed accordingly and is in regular follow-up. Benign ovarian tumours are mostly asymptomatic or present with nonspecific symptoms, of which abdominal pain and mass are seen in many cases. The commonest of these tumours is a benign mature cystic teratoma or dermoid cyst, which is bilateral. Though only one per cent contain a secondary malignancy arising from one of their components, early recognition and timely intervention are necessary to avoid untoward complications. Therefore, we recommend follow-up of such cases with radiological and blood investigations.
Assessment of Endocrine, Metabolic, and Fibrinolytic Profile and Its Association with BMI in Polycystic Ovarian Syndrome
Authors: Swathi A. , Vijayalakshmi  , Yogananda Reddy I.
Published: February 2023

Polycystic ovarian syndrome is a typical endocrine disorder that occurs in women and has a significant impact on the reproductive, metabolic, endocrine, and fibrinolytic systems. It is a heterogeneous clinical condition caused by multiple factors, especially obesity. Furthermore, metformin is the classical treatment approach for PCOS, which has conflicted results. The current study aimed to find out the effect of the usage of metformin on metabolic, fibrinolytic, and reproductive profiles between obese women with PCOS and non-obese women with PCOS. A cross-sectional study was carried out on 200 women diagnosed with PCOS and divided into two groups based on BMI. Each group was further subdivided into three subgroups (A, B, and C) based on their prescribed treatment. In addition, 50 age-matched controls were selected to compare the outcome. The reproductive hormones, lipid profile, glycaemic index, and fibrinolytic profile were measured in each group and compared to find the desired association. The demographic variables did not show significant variation within or between the groups except BMI. Group IA has shown better metabolic variables, Group IB has an improved endocrine profile, and Group IC has a better fibrinolytic profile(p>0.01**). Group II B has shown a better metabolic and endocrine profile, whereas it is significantly higher in the fibrinolytic profile (p>0.01**). Cumulatively Group II has a drastic reduction in all variables than group I(p>0.01**) except few non-significant variables. Obese PCOS patients are at an increased risk for complications such as endometrial hyperplasia, metabolic syndrome, and vascular thrombosis. Metformin and OCP are highly beneficial as they reduce the risk of insulin resistance and glucose intolerance and improve ovarian functions for a better reproductive life.
Premenarchal ovarian torsion
Authors: Eilbert Wesley , Nguyen Henry
Published: February 2023

Ovarian torsion is a common gynecologic emergency seen in women of all ages, mostly in reproductive women, resulting in ischemia and necrosis of the adnexal tissue. However, it is rare in premenarchal girls. This article reviews the limited published literature, and discusses special considerations about premenarchal ovarian torsion.
Percepção de diabéticos quanto à vulnerabilidade de sua condição de saúde ao novo coronavírus e as medidas de prevenção implementadas
Authors: Dias Ernandes Gonçalves , Lacerda Kézia Hellen , Barbosa Larissa Rayane Mendes , Araújo Rondinele Antunes de , Caldeira Maiza Barbosa
Published: February 2023

Objetivou-se investigar a percepção de diabéticos quanto à vulnerabilidade de sua condição de saúde ao novo coronavírus e as medidas de prevenção implementadas. Trata-se de um estudo descritivo, qualitativo realizado com 14 portadores de Diabetes Mellitus com idade entre 40 e 77 anos usuários de uma Unidade de Saúde da Família de Porteirinha, Minas Gerais. Os dados foram coletados no período de fevereiro a março de 2021 por meio de uma entrevista semiestruturada e analisados mediante Análise Temática. Os informantes manifestaram sentimento de medo em relação às complicações da Corona Vírus Disease e a transmissibilidade do vírus e perceberam-se mais ansiosos. Como medidas de prevenção adotaram o isolamento, distanciamento social, uso de máscara e higienização das mãos e objetos. Acredita-se que o fato de pertencer a um grupo de maior vulnerabilidade para complicações derivadas da infecção pelo novo coronavírus não tenha acentuado os sentimentos dos portadores de Diabetes Mellitus para além daquilo observado na população em geral. Isto pode estar relacionado a este público ter conhecimento limitado quanto à gravidade dessa infecção associada à Diabetes Mellitus e/ou ao trabalho de conscientização realizado pelos profissionais de saúde e pela mídia profissional, porém isso precisa ser melhor esclarecido em novos estudos.
Produção do espaço e metamorfoses do mercado público de Montes Claros/MG
Authors: Chaves Costa Lunna , Coelho de Oliveira Daniel , Soares de França Iara
Published: February 2023

O presente trabalho analisa, historicamente, como surgiu e se desenvolveu o Mercado Central de Montes Claros/MG. Para isso, o artigo buscou compreender a origem e a trajetória da sua construção, que vai desde o primeiro Mercado Central, construído em 1899, até o último Mercado Central Christo Raeff Nedelkoff, edificado em 1988 e objeto principal deste estudo. Para o desenvolvimento da pesquisa, a metodologia utilizada partiu da integração de dois métodos: quantitativo e qualitativo, com vistas a adquirir maior confiança nos dados, por meio do cruzamento das conclusões. Foi realizado um levantamento bibliográfico e pesquisa documental junto a jornais, revistas, projetos, mapas e fotografias a respeito do Mercado Central de Montes Claros. Além disso, foram aplicados questionários semiestruturados para os diversos agentes históricos, que contribuíram para o entendimento das transformações nesses espaços. A principal consideração constatada foi que o primeiro Mercado Central ainda vive no imaginário da população montesclarense e está presente em diversas manifestações artísticas da cidade. Ademais, a sua demolição não foi e ainda não é bem aceita pela maioria das pessoas. Quanto ao Mercado Central Christo Raeff Nedelkoff, foi percebido que se trata de um espaço que abriga conflitos dos mais diversos, que vão desde a conservação do seu espaço físico até o direito de sucessão dos pontos de venda, e se coloca como um problema para a administração municipal, pois, por mais que figure como reserva das tradições da sociedade, ainda necessita de readequações estruturais.
Dysfunctional design of campaign finance regulatory and post-election corruption
Authors: Chandranegara Ibnu Sina , Bakhri Syaiful
Published: February 2023

This study begins with the condition that almost every election held in Indonesia lacks accountability and transparency in campaign finance report cases. Matched to Mietzner’s (2015) and Briffault’s (2010) reports, there are always problems with the non-functioning of campaign finance arrangements in upholding the principles of transparency and accountability. As a result, the lack of accountability and transparency in implementing campaign finance arrangements often results in conflicts of interest that lead to post-election corruption. This article aims to discover the factors that hinder the functioning of campaign finance regulations that can encourage enforcement transparency and accountability. This research uses normative juridical methods with a comparative law approach. The object of this research is the election campaign funding regulation, especially local elections in Indonesia and focuses on the dysfunctional design of campaign finance regulations on local head elections. We found that the candidates often violate existing campaign finance regulations, with election administrators, law enforcement and the public openly tolerating such violations. Campaign finance regulations continue to develop, but they only prioritize administrative aspects in their implementation. In conclusion, changes needed to optimize fund management are funds obtained from campaigns owned by individuals and then have a reasonable candidate wealth ratio.
An assessment of the current epidemiological and laboratory capacities for influenza-like illnesses and Severe Acute Respiratory Infection surveillance, Yemen 2022.
Authors: BIN-AZOON NASREEN , Alwaleedi Ali , Thabet Ahmed , awad adham , ALAMODI ADED , Gailani Ammar Al , shafi bakil
Published: February 2023

Background and objectives: To re-activate infuneza sentinel surveillance
system in Yemen after disruption related to repurposing for COVID-19
pandemic. WHO Country Office (CO) in collaboration with Yemen’s Ministry
of Public Health and Population (MOPH&P) jointly conducted an
assessment mission to assess the current situation of the influenza
sentinel surveillance system and assess its capacity to detect influenza
epidemics and monitor trends in circulating influenza and other
respiratory viruses of epidemic and pandemic potential. This study
presents the results of the assessment for three sentinel sites located
in Aden, Taiz and Hadramout/Mukalla. Methodology: A mixed methods
approach was used to guide the assessment process and to help achieve
the objectives. Data was collected as follows: desk review of the
sentinel sites records and data; interviews with stakeholders, including
key informants and partners; and direct observation through field visits
to the sentinel sites, MOPH&P and the Central Public Health Laboratory
(CPHL). Two assessment checklists were used: assessment of sentinel
sites for SARI surveillance, and checklist for assessment of
availability of SARI sentinel surveillance. Results and conclusion:
COVID19 has affected health systems and services, and this was
demonstrated in this assessment. The influenza sentinel surveillance
system in Yemen is not effectively functional, however there’s plenty of
room for improvement if investment in the system’s restructuring,
training, building technical and laboratory capacities, and conducting
continuous and regular supervision visits.
B-GATA factors are required to repress high-light stress responses in Marchantia polymorpha and Arabidopsis thaliana
Authors: Schwechheimer Claus , Schröder Peter , Gutsche Nora , Winkler Jana , Hedtke Boris , Grimm Bernhard
Published: February 2023

GATAs are evolutionarily conserved zinc-finger transcription factors
from eukaryotes. In plants, GATAs can be subdivided into four classes, A
– D, based on their DNA-binding domain, and into further subclasses
based on additional protein motifs. B-GATAs with a so-called LLM-domain
can already be found in algae, but bryophytes and angiosperms also
contain B-GATAs with a HAN-domain. The angiosperm B-GATA family is
expanded and can be subdivided into family members with either a HAN- or
an LLM-domain. The B-GATA family in the liverwort Marchantia
polymorpha and the moss Physcomitrium patens is restricted to
one and four family members, respectively, and all family members
contain a HAN- as well as an LLM-domain. Here, we characterize mutants
of the single B-GATA from Marchantia polymorpha. We reveal that
this mutant has defects in thallus growth and in gemma formation.
Transcriptomic studies uncover that the B-GATA mutant displays a
constitutive high-light stress response, a phenotype that we then also
confirm in mutants of Arabidopsis thaliana LLM-domain B-GATAs,
suggesting that the B-GATAs have a protective role towards high-light
stress.
Body size-dependent effects on the distribution patterns of phoretic mites of the multi-symbiont Rhynchophorus ferrugineus (Olivier, 1790) host
Authors: Matos Inês , Silva Diogo , Oliveira Joāo , Gonçalves Claúdia , Alves Rita , Pereira Nuno , Catarino Francisco , Ameixa Olga , Sousa José Américo , Rangel Luis , Santos Maria Joao , AYRA-PARDO Camilo
Published: February 2023

Phoretic mites have been found attached to different body parts of red
palm weevil (RPW), Rhynchophorus ferrugineus (Olivier, 1790), to
disperse. However, the question of how the patterns of attachment sites
are formed remains intriguing. Here, we conducted the first study of
RPW-associated phoretic mites in Portugal, particularly in the districts
of Viana do Castelo, Braga, Porto and Aveiro in Northern Portugal
(macrohabitat), and investigated the patterns of mite distribution on
six body parts of RPW (microhabitat). At the macrohabitat level, we
detected seven phoretic mite taxa actively using RPW host in each of the
four studied districts, all documented for the first time in association
with this invasive exotic species in Portugal. However, their relative
abundance (species evenness) varied between districts, as did species
diversity. All examined weevils carried mites, and the prevalence of the
different taxa did not differ between districts or sex of weevils.
Measured by mean abundance and degree of aggregation, Centrouropoda sp.
proved to be the common dominant taxon, while Acarus sp. and C.
rhynchoporus were considered common subordinate taxa and Uroovobella
sp., Mesostigmata, N. extremica and Dendrolaelaps sp. sparse taxa. At
the microhabitat level, all taxa were present in all body parts of the
RPW; the highest abundance was in a region encompassing the inner
surface of the elytra and the membranous hind wings (subelytral space).
Analysis of niche overlap revealed that the distribution patterns of
phoretic mite taxa on the RPW were not randomly structured. In the
subelytral space, interspecific coexistence of mites increased as a
function of body size difference with the dominant Centrouropoda sp. We
conclude that the distribution patterns of RPW-associated phoretic mites
show body size-dependent effects that resulted in the dominant taxon
displacing similar size taxa and accepting taxa with which it has the
greatest size difference as co-habitants.
DNA metabarcoding of mock communities highlights potential biases when assessing Neotropical fish diversity
Authors: Hilário Heron , Mendes Izabela , Sales Naiara , Carvalho Daniel
Published: February 2023

Despite the increasing popularity of DNA metabarcoding in the assessment
of aquatic ecosystems using fish eDNA or ichthyoplankton, challenges
have hampered its broader application in the Neotropical freshwaters.
Using five mock communities composed of fish species from two
Neotropical river basins, we evaluated the influence of DNA
concentration and choice of mitochondrial 12S molecular markers (MiFish,
NeoFish and Teleo) on species detection and Relative Read Abundance
(RRA) using DNA metabarcoding. Of the three 12S markers analysed, only
MiFish detected all species from all mock communities. The performance
of a taxonomy-free approach using ASV/MOTUs was not as precise as
assigning DNA reads to species using a curated 12S library that includes
approximately 100 fish species, since more than one ASV/MOTU was
observed for the same specimen. Thus, here we showcase the importance of
a custom reference database to allow precise assignment of Neotropical
fish species in metabarcoding studies and that the RRA is dependent on
community composition, marker and DNA concentration. We highlight the
importance of controlled experiments using known species communities
before large investments are made in assessing biodiversity using
non-invasive methods that apply DNA metabarcoding.
Evidence regarding intermediate heterogeneous hypothesis on diversity maintenance trade-off to heterogeneity through a novel microhabitat partition under sheltered-canopy environments
Authors: Gao Lu , He Yuejun , Tan Qiyu , Umer Muhammad , Kang Liling , Guo Yun , Shen Kaiping , Xia Tingting , Liu Yuan , Chen Danmei , Zang Lipeng , Liu Qingfu , Chen Hongchun , Zhao Yan , Zhao Ying
Published: February 2023

Heterogeneity is ubiquitous and crucial to maintaining biodiversity due
to variations in spatiotemporal resources. However, it is unclear which
habitat heterogeneity can maintain greater species and functional
diversity because of the difficulties in qualifying habitat
heterogeneity, while the karst ecosystem provides a typical
heterogeneous paradigm. We surveyed 50 plots of 20 m × 20 m divided into
200 subplots in the karst mountain forests. Information on microhabitats
was collected innovatively for quantifying habitat heterogeneity through
partitioning components of the stone hole, groove, trench, chink, stone
surface, and soil surface under sheltering-canopy environments. We
explored the relationship and effect of microhabitat components on
species diversity (SD) and functional diversity (FD) through regression
analysis, Mantel’s test, and structural equation model (SEM). These
results showed that the microhabitat ratio significantly correlated with
habitat heterogeneity, mainly through the soil surface and stone surface
ratios. The microhabitat partition affected heterogeneity along with
species and functional diversity by presenting a humped curve. It
suggested that the moderate heterogeneity maintained greater SD of
Patrick richness and Shannon-Wiener and FD of FRic and FEve in a
heterogeneity range of 1.121 to 1.280, responding to the sum ratio of
0.778 to 0.863 of soil and stone surface. Mantel’s test indicated that
SD and FD were affected by microhabitat components, mainly through stone
chink, stone surface, and soil surface; meanwhile, the heterogeneity
directly affected SD and FD and indirectly affected FD by affecting SD
through SEM pathway analysis. This study has shown that the moderate
heterogeneity maintained more incredible species and functional
diversity depending on the trade-off from microhabitat partition to
heterogeneity, providing evidence of intermediate heterogeneous
hypothesis on the significance of understanding biodiversity
maintenance.
Preconception Expanded carrier screening for reproductive risk assessment: Prevalence of carrier status in china
Authors: Zhao QiongZheng , Li Yanqi , Yu Lifei , Liang Qi , Cai Yanan , Han Tingting , Liu Jinrui , Yi Jiangyan , Zhang Kun , Yuan Linlin , Zhao Jie , Huang Weidong
Published: February 2023

PECS identifies couples who may have had children with autosomal
recessive diseases. The current prevalence of carrier status for these
conditions in China is not well defined. This study assesses the
prevalence of carrier status of selected genetic conditions utilizing an
expanded genetic carrier screening panel in a large population of china
patients. Methods: A retrospective chart review of all patients tested
with a single PECS panel at Xinjiang jiayin hospital from 2019 to 2021
were included, and the prevalence of pathogenic positive carrier status
in the china population was evaluated. The pathogenic variants were
classified as per the American College of Medical Genetics criteria.
Results: 6437 individuals were analyzed with PECS testing for 208
genetic conditions. 2749 carriers (42.71%) were identified with 799
pathogenic variants in 166 different genes. The most prevalent alleles
found were associated with Hemochromatosis, Deafness autosomal recessive
1A, cystic fibrosis, Gilbert syndrome, Phenylketonuria, and Krabbe
disease. 71 of the 2653 participating couples (2.68%) were identified
as being at-risk couples. Conclusion: This study reviews the Chinese
population-based carrier screening panel prevalence, which is different
from other countries, possibly due to the different panel/screening
platform used. In order to get a better study of the prevalence of
carrier screening in the Chinese population, the genetic screening scope
should be expanded to obtain more carrier conditions. At the same time,
we suggest that couples who have needs for fertility, regardless of
their ethnic background, should undergo carrier screening and genetic
counseling prior to receiving reproductive medicine treatment
SARS-CoV-2 infection of kidney tissues in some severe and fatal cases of COVID-19
Authors: Ly Hinh
Published: February 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
can lead to diverse clinical manifestations and pathologies that involve
multiple organs. Even though the disease severity is manifested mainly
in the respiratory tract, which is the primary target of SARS-CoV-2
infection, acute kidney injury in the form of acute tubular necrosis has
also been noted in some COVID-19 cases. It is not entirely clear whether
renal cells can be infected by the virus that might be involved in acute
kidney disorder. In a recent publication by Radovic and colleagues (1)
that has been selected as the editor’s choice paper published in the
Journal of Medical Virology, the authors provided strong
histopathological and immunofluorescence evidence of SARS-CoV-2
infection and tissue injury of renal parenchymal and tubular epithelial
cells, which strongly suggest an active viral replication in the kidney
of some severe and fatal COVID-19 cases, and to a lesser extent, a
potential role for innate immune cells in viral infection and renal
disease pathogenesis.
Mechanisms of nonalcoholic fatty liver disease induced by antibiotic resistance and evaluation of bacteriophag-efficacy
Authors: Jin Xi , Wu Jiu-Sheng , Wang Chenghao , Tang Biao , Yang Hua , Liu Yuehuan
Published: February 2023

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic
liver disease in the world. With the deepening understanding of NAFLD,
more and more evidence has shown that NAFLD is a group of highly
heterogeneous diseases, which is closely related to metabolic
dysfunction. Recent studies have shown that the occurrence of
nonalcoholic fatty liver disease is closely related to the dysbiosis of
intestinal flora. However, due to the abuse of antibiotics, long-term
use of broad-spectrum antibiotics is the most common cause of intestinal
flora disorders. Endocrine and metabolic disorders caused by intestinal
microbiota imbalance promote the occurrence of obesity, and on this
basis induce the emergence of NAFLD. In response to the current
situation of antibiotic resisftance pandemic, phage therapy has emerged
as a potential solution to solve the problem of bacterial resistance.
Relevant clinical studies have shown that fecal bacterial
transplantation (FMT) can improve the clinical symptoms of patients with
chronic liver disease, in which phage participate in the regulating
effect. This suggests that phages may play a role in the treatment of
non-alcoholic fatty liver disease caused by antibiotic resistance, but
there is insufficient clinical evidence to support this therapy.
Therefore, this review will discuss the mechanism of non-alcoholic fatty
liver disease caused by antibiotics resistance and evaluate the
therapeutic effect of bacteriophages.
CHEMICAL PROFILE OF COLD PRESSED BEECH NUT (Fagus Sylvatica L.) OIL
Authors: Obranovic Marko , Kraljic Klara , Skevin Dubravka , Balbino Sandra , Tomljanović Kristijan
Published: February 2023

The objective of the study was to evaluate the chemical characteristics
of cold-pressed beech nut oil. The nuts collected from the forest
consisted of 25.35% water, 13.19% oil, and 19.40% protein. Dominant
fatty acid was linoleic (40.5%) followed by oleic (35.0%) and gondoic
acid (7.7%). All four tocopherols were present in the oil with dominant
γ- tocopherol 99.38 mg 100g-1 oil. Total sterol content was 2708.73 mg
kg-1 oil with β-sitosterol accounting for 80.5% of all sterols. The
oil’s main characteristics were the relatively high content of
tocopherols and gondoic acid, dominant oleic-linoleic fatty acid
profile, and higher levels of carotenoids.
A case study on the content of 1-Deoxynojirimycin in some mulberry varieties (Morus Alba L.) cultivated in Bulgaria
Authors:   Agricultural University-Plovdiv, Bulgaria, Avramova Krasimira , Tsenov Panomir ,   Agricultural Academy – Scientific Center of Sericulture, Vratsa, Grekov Dimitar ,   Agricultural University – Plovdiv, Bulgaria
Published: February 2023

In recent years, more and more attention has been given to the naturally occurring alkaloids due to their unique bioactive properties. In particular, 1-Deoxynojirimycin (DNJ), an iminosugar derivative, has been attracting growing attention as anti-diabetic, anti-obesity, anti-microbial, anti-cancer, and cardioprotective agent. This alkaloid is detected in various parts of the mulberry plant, such as leaves, latex, and root bark. The predominant active substance in the mulberry leaf extract is 1-deoxynojirimycin (DNJ), known for its role as a blood sugar level regulator. The present research aims at analyzing the impact of vegetation stages and mulberry variety on the content of 1-deoxynojirimycin in dried mulberry leaves. It has been concluded that the vegetation stage and variety have an effect on the content of 1-deoxynojirimycin in mulberry leaves, as the values of DNJ are the highest in the end of July and the lowest in the middle of June. The highest DNJ content is detected for the following varieties: Kokuso 21, Kinriu and Italian106; and the lowest content in Bulgarian 24 and Kokuso 27 varieties.