bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Natural Bioactives and their Nanocarriers for Overcoming Oxidative Stress Induced Cancer
Authors: Mittal Saurabh , Ashhar Muhammad Usama , Ahuja Alka , Ali Javed , Baboota Sanjula
Published: June 2021

Background:

Oxidative stress and free radicals are harmful to human health. Reactive
oxygen species are the major source of oxidative stress and are one of the major causes
of cancer development. Cancer is one of the leading causes of death worldwide. Prolonged
use of synthetic chemotherapeutic due to their low bioavailability leads to systemic
toxic side effects. To surmount this problem, the use of antioxidants is recommended as they
have the ability to counteract oxidative stress and mitigate its effects on human health. They
inhibit various pathways that are involved with the initiation and progression of cancer. Various
nanoformulations have been used to deliver these antioxidants (curcumin, mangiferin,
quercetin) in the treatment of various cancer for overcoming oxidative stress.

Objective:

The main focus of this review article is to illustrate various studies performed
using nanocarriers of natural bioactives to overcome oxidative stress and cancer associated
with it. It also describes pathways associated with the induction, initiation and progression
of cancer due to reactive oxidative species.

Methods:

Research articles that focused on the use of natural bioactives and their nanoformulations
for the treatment of various cancers induced due to oxidative stress, were collected
from various search engines like PubMed, Science Direct and Google Scholar, using
keywords like oxidative stress, antioxidants, cancers, ROS, etc.

Conclusion:

Natural bioactives have shown great potential in overcoming oxidative stress for
the treatment of various cancers. However, extensive research is required so that these antioxidants
and their nanocarriers can be used for the welfare of mankind, in the treatment of various
cancers, in the near future.
Structures, Synthesis and Biological Activities of Nonactic Acid and Its
Derivatives
Authors: Hu Jianan , Zhang Jirui , He Jian
Published: June 2021

:

Nonactic acid, which is a macrocyclic nonactin subunit, contains four asymmetric
centers and has the molecular formula of C10H18O3. Due to their various biological activities
and challenging structural characteristics, nonactic acid and its derivatives have attracted
much attention from scientists since 1955. These compounds possess significant antibacterial,
insecticidal and acaricidal activities, as well as a promoting effect on plant growth. However,
the studies in the anticancer activities of these compounds are limited. It is noticed that some
derivatives of nonactic acid show significant cytotoxicity toward different human cancer cells,
from which, a basic structure-activity relationship might be able to obtain. On the basis of
these progresses, we believe that this review may provide new ideas for generating potent
anticancer compounds bearing the same pharmacophores derived from those macrocyclic
molecules.
Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines
Authors: Gouda Magy , Bawazeer Majed , Hegazy Lamees , Azab Mohamed , Elagawany Mohamed , Rateb Mostafa , Yaseen Mohammed , Elgendy Bahaa
Published: June 2021

Background:

Spirooxindoles are privileged scaffolds in medicinal chemistry, which were identified
through Wang’s pioneering work as inhibitors of MDM2-p53 interactions.

Objective:

To design and synthesize 2,6-diarylidenecyclohexanones and dispiro[oxindole-cyclohexanone]-
pyrrolidines having potential antitumor effect.

Method:

Dispiro[oxindole-cyclohexanone]-pyrrolidines 6a-h were synthesized in a regioselective manner via
1,3-dipolar cycloaddition reaction of 2,6-diarylidenecyclohexanones 3a-h, isatin, and sarcocine. Compounds
6a-h were alkylated to give (7-10)a,b. All compounds were evaluated in vitro for their antitumor activity and
cytotoxic selectivity against breast cancer cell lines (MCF-7 and MDA-MB-231), breast fibrosis cell line
(MCF10a), and placental cancer cell line (JEG-3). Molecular modeling inside the MDM2 binding site was performed
using AutoDock4.2.

Results:

Synthesized compounds showed antitumor activity comparable to tamoxifen and compounds 3a,b,f,g
and 9a,b showed selective cytotoxicity against tumor cells but reduced toxicity toward MCF-10a cells. Molecular
modelling shows that both classes of synthesized compounds are predicted to fit the deep hydrophobic cleft
on the surface of MDM2 and mimic the interactions between p53 and MDM2.

Conclusion:

The synthesized compounds have antitumor activity against MCF-7, MDA-MB-231, and JEG-3.
Few compounds showed a selective cytotoxic effect and may have the potential to inhibit MDM2 and stimulate
p53. In the future, studies regarding the optimization of medicinal chemistry as well as mechanistic studies will
be conducted to enhance the inhibition effect of identified compounds and elucidate their mechanism of action.
Weighted Gene Co-expression Network Analysis Identifies Five Hub
Genes Associated with Metastasis in Synovial Sarcoma
Authors: Feng Helin , Wu Hongzeng , Zhang Benzheng , Zhao Jiazheng , Zhao Yi , Ma Xiaowei
Published: June 2021

Background:

Synovial sarcoma (SS) refers to a malignant soft tissue sarcoma (STS)
which often comes about to children and adults and has a poor prognosis in elderly patients.
Patients with local lesions can be treated with extensive surgical resection combined with adjuvant
or radiotherapy, whereas about half of the cases have recurrent diseases and metastatic lesions, and
five-year survival ratio is assessed within the range of 27% - 55% only.

Method:

We downloaded a set of expression profile data (GSE40021) related to SS metastasis
based on the Gene Expression Omnibus (GEO) database, and selected distinctly represented genes
(DEGs) related to tumor metastasis. WGCNA was used to emphasize the DEGs related to tumor
metastasis, and obtain co-expression modules. Then, the module most related to SS metastasis was
screened out. The genes of enriched in this module were analyzed by Gene Ontology (GO)
functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway improvement
analysis. Cytoscape software was used for constructing protein-protein interaction (PPI) networks,
and screening hub genes were made in virtue of Oncomine analysis.

Result:

We selected 514 DEGs, consisting of 210 up-regulated genes and 304 down-regulated
genes. Through WGCAN, we got seven co-expression modules and the module most related to SS
metastasis was turquoise module, which contained 66 genes. Finally, we screened out five hub
genes (HJURP, NCAPG, TPX2, CENPA, NDC80) through CytoHubba and Oncomine analysis.

Conclusion:

In this study, we screened out five hub genes to help clinical diagnosis and serve as
the latent purpose of SS treatment.
Exploring Dual Agonists for PPARα/γ Receptors using Pharmacophore
Modeling, Docking Analysis and Molecule Dynamics Simulation
Authors: Li Shao-Yong , Cheng Xian-Chao , Ding Ting-Ting , Liu Ya-Ya , Zhang Li-Ming , Shi Jia-Rui , Xu Wei-Ren
Published: June 2021

Background:

The Peroxisome Proliferator-Activated Receptors (PPARs) are ligandactivated
transcription factors belonging to the nuclear receptor family. The roles of PPARα in
fatty acid oxidation and PPARγ in adipocyte differentiation and lipid storage have been widely
characterized. Compounds with dual PPARα/γ activity have been proposed, combining the benefits
of insulin sensitization and lipid lowering into one drug, allowing a single drug to reduce
hyperglycemia and hyperlipidemia while preventing the development of cardiovascular
complications.

Methods:

The new PPARα/γ agonists were screened through virtual screening of pharmacophores
and molecular dynamics simulations. First, in the article, the constructed pharmacophore was used
to screen the Ligand Expo Components-pub database to obtain the common structural
characteristics of representative PPARα/γ agonist ligands. Then, the accepted ligand structure was
modified and replaced to obtain 12 new compounds. Using molecular docking, ADMET and
molecular dynamics simulation methods to screen the designed 12 ligands, analyze their docking
scores when they bind to the PPARα/γ dual targets, their stability and pharmacological properties
when they bind to the PPARα/γ dual targets.

Results:

We performed pharmacophore-based virtual screening for 22949 molecules in Ligand
Expo Components-pub database. The compounds that were superior to the original ligand were
performed structural analysis and modification, and a series of compounds with novel structures
were designed. Using precise docking, ADMET prediction and molecular dynamics methods to
screen and verify newly designed compounds, and the above compounds show higher docking
scores and lower side effects.

Conclusion:

9 new PPARα/γ agonists were obtained by pharmacophore modeling, docking
analysis and molecular dynamics simulation.
Screening of Candidate Pathogenic Genes for Spontaneous Abortion Using
Whole Exome Sequencing
Authors: Li Guang , Ding Jiayi , Zhu Qingwen , Liu Jia , Chen Li , Zhou Yiwen , Zhou Tao , Bian Wenjun , Ding Guohui
Published: June 2021

Background:

Spontaneous abortion is a common disease in obstetrics and reproduction.

Objective:

This study aimed to screen candidate pathogenic genes for spontaneous abortion using
whole-exome sequencing.

Methods:

Genomic DNA was extracted from abortion tissues of spontaneous abortion patients and
sequenced using the Illumina HiSeq2500 high-throughput sequencing platform. Whole exome sequencing
was performed to select harmful mutations, including SNP and insertion and deletion
sites, associated with spontaneous abortion. Gene Ontology (GO) and Kyoto Encyclopedia of
Genes and Genomes (KEGG) pathway enrichment analyses and gene fusion analyses were performed.
MUC3A and PDE4DIP were two novel mutation genes that were screened and verified by
PCR in abortion tissues of patients.

Results:

A total of 83,633 SNPs and 13,635 Indel mutations were detected, of which 29172 SNPs
and 3093 Indels were screened as harmful mutations. The 7 GO-BP, 4 GO-CC, 9 GO-MF progress,
and 3 KEGG pathways were enriched in GO and KEGG pathway analyses. A total of 746 gene fusion
mutations were obtained, involving 492 genes. MUC3A and PDE4DIP were used for PCR verification
because of their high number of mutation sites in all samples.

Conclusion:

There are extensive SNPs and Indel mutations in the genome of spontaneous abortion
tissues, and the effect of these gene mutations on spontaneous abortion needs further experimental
verification.
The Utility of MRI to Diagnose Ischifemoral Impingement by Assessing the Ischiofemoral and Quadratus Femoris Spaces During Femoral External Rotation
Authors: Zhang Ping , Zhang Yu Xiang , Yu Bao Hai , Shao Shu Ying , Chen Xiao Shuai , Zhou Xiaoyue , Zhao Jian
Published: June 2021

Objective:

The purpose of this study was to explore if the dimensions of the ischiofemoral
space on MRI vary with changes in external femoral rotation in Ischifemoral Impingement patients
relative to healthy control; if so, to determine the optimal diagnostic cutoff values of these dimensions
in Ischifemoral Impingement.

Methods:

The study included 43 clinically confirmed Ischifemoral Impingement patients and 50
healthy volunteers. All subjects underwent hip MRI examinations with their hips externally rotated
at 0°, 30° and 60°. The IFS and QFS were measured respectively at each angle. The measurements
were compared between the IFI group and the control group to determine the optimal diagnostic
cutoff values for diagnosing IFI by using IFS and QFS measurements.

Results:

In the IFI group, the spaces were smaller than those of the control group at all rotation angles
(P < 0.05 for each). When external rotation angles were increased, the IFS and QFS tended to
decrease. QFSs were smaller in the case group than the control group at each rotation angle. The receiver
operating characteristic areas under the curves of IFS and QFS in a neutral position of 0°
were highest.

Conclusion:

Both of the IFS and QFS spaces of IFI patients were found to be smaller than those of
control group, regardless of the external hip rotation angles. A neutral position of 0° was deemed
the best position for diagnosing IFI. The diagnostic cutoff values of IFS and QFS were 2.44cm and
1.34cm in the neutral position, respectively.
Development of Precision Medical Technology and its Current Clinical Applications
Authors: Gao Kaiye , Wang Ziwen , Chi Yuanying , Peng Rui
Published: June 2021

Background:

Precision medicine has emerged with the development of science and technology
and the rise of big data. This study first defines and presents the advantages of precision
medicine and then introduces the development of three technologies: gene sequencing, cellular immunotherapy,
and gene editing. The clinical applications of precision medicine in lung cancer, cervical
cancer, breast cancer, and prostate cancer are thus analyzed. Lastly, the existing problems and
future development directions of precision medicine are identified. The introduction of gene sequencing,
bioanalytical techniques, and big data analysis tools has propelled medicine into the era of
precision medicine. Key technologies in precision medicine form the foundation of its development.
Therefore, this study elaborates on the development of key technologies in precision medicine, the
current status of its clinical application, and the main problems that currently exist. This study also
suggests solutions to the problems.

Objective:

To systematically explain the development and principle of three core technologies in
precision medicine and to predict the main research trends of precision medicine.

Results:

Research in gene sequencing, cell immunotherapy, and gene editing technology has shown
significant progress, and accurate medical treatment has achieved remarkable results, effectively
prolonging the survival time and improving the quality of life of patients.

Conclusion:

Precision medicine has made significant achievements, but problems remain. Ensuring
safety and efficiency in precision medicine should be the focus of future research.
Предпосевная обработка озимой пшеницы поверхностным разрядом: устойчивость к низким температурам
Authors: Гундарева С.В. , Лазукин А.В. , Никитин А.М. , Романов Г.А.
Published: June 2021

The treatment of soft winter wheat seeds of long-term storage with products of low-temperature plasma of the surface discharge was carried out according to an indirect scheme, i.e. without a contact between the layer of stationary seeds and the surface discharge existing in a strip electrode system with a distance between the strips of 10 mm. The treatment was carried out at an exposure time of 60 seconds in two modes of feeding the electrodes: with a sinusoidal voltage of 16 kHz/1.5 kV and 4.4 kHz/2.4 kV. The biometric parameters of seedlings on the third and seventh days, the tolerance of cold hardened seedlings to low temperatures, and the seed contamination were evaluated. It was found that the performed treatment does not provide an increase in quality characteristics of germination and tolerance to low temperatures, and also does not reduce seed contamination in conditions of high mycobiota level.
Digital Self-Management Support Tools in the Care Plan of Patients With Cancer: Review of Randomized Controlled Trials
Authors: Adriaans Danielle JM , Dierick-van Daele Angelique TM , van Bakel Marc Johannes Hubertus Maria , Nieuwenhuijzen Grard AP , Teijink Joep AW , Heesakkers Fanny FBM , van Laarhoven Hanneke WM
Published: June 2021

Background

Digital self-management support tools (DSMSTs)—electronic devices or monitoring systems to monitor or improve health status—have become increasingly important in cancer care.

Objective

The aim of this review is to analyze published randomized clinical trials to assess the effectiveness of DSMSTs on physical and psychosocial symptoms or other supportive care needs in adult patients with cancer.

Methods

Five databases were searched from January 2013 to January 2020. English or Dutch language randomized controlled trials comparing DSMSTs with no intervention, usual care, alternative interventions, or a combination and including patients aged ≥18 years with pathologically proven cancer in the active treatment or survivorship phases were included. The results were summarized qualitatively.

Results

A total of 19 publications describing 3 types of DSMSTs were included. Although the content, duration, and frequency of interventions varied considerably across studies, the commonly used elements included an assessment component, tailored symptom self-management support, an information section, a communication section, and a diary. Significant positive effects were observed on quality of life in 6 (out of 10) studies, on anxiety in 1 (out of 5) study and depression in 2 (out of 8) studies, on symptom distress in 5 (out of 7) studies, on physical activity in 4 (out of 6) studies, on dietary behavior in 1 (out of 4) study, and on fatigue in 2 (out of 5) studies. Moreover, significant negative effects were observed on anxiety in 1 (out of 5) study and depression in 1 (out of 8) study. Most interventions were web-based interventions; 2 studies used mobile apps, and 1 study used a game as a DSMST. The overall quality of the studies was found to be good, with 13 out of 19 studies classified as high quality.

Conclusions

This review suggests that DSMSTs have a beneficial effect on the quality of life. For effects on other patient outcomes (eg, anxiety and depression, symptom distress, physical activity, dietary behavior, and fatigue), the evidence is inconsistent and limited or no effect is suggested. Future research should focus on specific tumor types, study different types of interventions separately, and assess the effects of specific interventions at different stages of disease progression.
COVID-19 Vaccine–Related Discussion on Twitter: Topic Modeling and Sentiment Analysis (Preprint)
Authors: Lyu Joanne Chen , Han Eileen Le , Luli Garving K
Published: June 2021

BACKGROUND

Vaccination is a cornerstone of the prevention of communicable infectious diseases; however, vaccines have traditionally met with public fear and hesitancy, and COVID-19 vaccines are no exception. Social media use has been demonstrated to play a role in the low acceptance of vaccines.

OBJECTIVE

The aim of this study is to identify the topics and sentiments in the public COVID-19 vaccine–related discussion on social media and discern the salient changes in topics and sentiments over time to better understand the public perceptions, concerns, and emotions that may influence the achievement of herd immunity goals.

METHODS

Tweets were downloaded from a large-scale COVID-19 Twitter chatter data set from March 11, 2020, the day the World Health Organization declared COVID-19 a pandemic, to January 31, 2021. We used R software to clean the tweets and retain tweets that contained the keywords vaccination, vaccinations, vaccine, vaccines, immunization, vaccinate, and vaccinated. The final data set included in the analysis consisted of 1,499,421 unique tweets from 583,499 different users. We used R to perform latent Dirichlet allocation for topic modeling as well as sentiment and emotion analysis using the National Research Council of Canada Emotion Lexicon.

RESULTS

Topic modeling of tweets related to COVID-19 vaccines yielded 16 topics, which were grouped into 5 overarching themes. Opinions about vaccination (227,840/1,499,421 tweets, 15.2%) was the most tweeted topic and remained a highly discussed topic during the majority of the period of our examination. Vaccine progress around the world became the most discussed topic around August 11, 2020, when Russia approved the world’s first COVID-19 vaccine. With the advancement of vaccine administration, the topic of instruction on getting vaccines gradually became more salient and became the most discussed topic after the first week of January 2021. Weekly mean sentiment scores showed that despite fluctuations, the sentiment was increasingly positive in general. Emotion analysis further showed that trust was the most predominant emotion, followed by anticipation, fear, sadness, etc. The trust emotion reached its peak on November 9, 2020, when Pfizer announced that its vaccine is 90% effective.

CONCLUSIONS

Public COVID-19 vaccine–related discussion on Twitter was largely driven by major events about COVID-19 vaccines and mirrored the active news topics in mainstream media. The discussion also demonstrated a global perspective. The increasingly positive sentiment around COVID-19 vaccines and the dominant emotion of trust shown in the social media discussion may imply higher acceptance of COVID-19 vaccines compared with previous vaccines.
Effects of Mobile App–Based Intervention for Depression in Middle-Aged and Older Adults: Mixed Methods Feasibility Study (Preprint)
Authors: Gould Christine E , Carlson Chalise , Ma Flora , Forman-Hoffman Valerie , Ranta Kristian , Kuhn Eric
Published: June 2021

BACKGROUND

Digital mental health interventions may help middle-aged and older adults with depression overcome barriers to accessing traditional care, but few studies have investigated their use in this population.

OBJECTIVE

This pilot study examines the feasibility, acceptability, and potential efficacy of the Meru Health Program, an 8-week mobile app–delivered intervention.

METHODS

A total of 20 community-dwelling middle-aged and older adults (age: mean 61.7 years, SD 11.3) with elevated depressive symptoms participated in a single-arm pilot study investigating the Meru Health Program, an app-delivered intervention supported by remote therapists. The program primarily uses mindfulness and cognitive behavioral skills to target depressive symptoms. A semistructured interview was completed at the baseline to establish current psychiatric diagnoses. Depressive symptoms were measured using the Patient Health Questionnaire and Patient-Reported Outcomes Measurement Information System (PROMIS) depression measures. Anxiety symptoms were measured using the Generalized Anxiety Disorder Scale and the PROMIS Anxiety measure. User experience and acceptability were examined through surveys and qualitative interviews.

RESULTS

In total, 90% (18/20) of the participants completed the program, with 75% (15/20) completing at least 7 of the 8 introductory weekly lessons. On average, participants completed 60 minutes of practice and exchanged 5 messages with their therapists every week. The app was rated as helpful by 89% (17/19) participants. Significant decreases in depressive (P=.03) and anxiety symptom measures (P=.01) were found; 45% (9/20) of participants showed clinically significant improvement in either depressive symptoms or anxiety symptoms.

CONCLUSIONS

The findings suggest that the commercially available Meru Health Program may be feasible, acceptable, and potentially beneficial to middle-aged and older adults. Although larger controlled trials are needed to demonstrate efficacy, these findings suggest that digital health interventions may benefit adults of all ages.
Development of a Connected Sensor System in Colorectal Surgery: User-Centered Design Case Study (Preprint)
Authors: Schwartz-Lasfargues Christel , Roux-Gendron Camille , Edomskis Pim , Marque Isabelle , Bayon Yves , Lange Johan F , Faucheron Jean Luc , Trilling Bertrand
Published: June 2021

BACKGROUND

A successful innovative medical device is not only technically challenging to develop but must also be readily usable to be integrated into health care professionals’ daily practice. Through a user-centered design (UCD) approach, usability can be improved. However, this type of approach is not widely implemented from the early stages of medical device development.

OBJECTIVE

The case study presented here shows how UCD may be applied at the very early stage of the design of a disruptive medical device used in a complex hospital environment, while no functional device is available yet. The device under study is a connected sensor system to detect colorectal anastomotic leakage, the most detrimental complication following colorectal surgery, which has a high medical cost. We also aimed to provide usability guidelines for the initial design of other innovative medical devices.

METHODS

UCD was implemented by actively involving health care professionals and all the industrial partners of the project. The methodology was conducted in 2 European hospitals: Grenoble-Alpes University Hospital (France) and Erasmus Medical Center Rotterdam (the Netherlands). A total of 6 elective colorectal procedures and 5 ward shifts were observed. In total, 4 workshops were conducted with project partners and clinicians. A formative evaluation was performed based on 5 usability tests using nonfunctional prototype systems. The case study was completed within 12 months.

RESULTS

Functional specifications were defined for the various components of the medical device: device weight, size, design, device attachment, and display module. These specifications consider the future integration of the medical device into current clinical practice (for use in an operating room and patient follow-up inside the hospital) and interactions between surgeons, nurses, nurse assistants, and patients. By avoiding irrelevant technical development, this approach helps to promote cost-effective design.

CONCLUSIONS

This paper presents the successful deployment over 12 months of a UCD methodology for the design of an innovative medical device during its early development phase. To help in reusing this methodology to design other innovative medical devices, we suggested best practices based on this case.
Correction: Quantifying Online News Media Coverage of the COVID-19 Pandemic: Text Mining Study and Resource (Preprint)
Authors: Krawczyk Konrad , Chelkowski Tadeusz , Laydon Daniel J , Mishra Swapnil , Xifara Denise , Gibert Benjamin , Flaxman Seth , Mellan Thomas , Schwämmle Veit , Röttger Richard , Hadsund Johannes T , Bhatt Samir
Published: June 2021

UNSTRUCTURED

REMOVE
Pola komunikasi organisasi pustakawan-guru dalam pemberian layanan prima perpustakaan
Authors: Rachmawati Tine Silvana , Agustine Merryam
Published: June 2021

Introduction. The purpose of this study is to examine the organizational communication patterns between librarians and teachers in providing quality library services. 

Data Collection Method. This is a qualitative research with a case study approach with librarians and teachers as samples. Data collection techniques were interviews, observations, and literature study.

Data Analysis. Data analysis techniques were conducted by reducing data, presenting data, and then making conclusions or data verification.

Results and Discussion. The results of this study indicate that a well-established organizational communication pattern between librarians and teachers consists of task coordination, problem-solving, information sharing, conflict resolution, and building togetherness or relationships. All of them supported excellent services.

Conclusion. Librarian who implement a good horizontal organizational communication model can provide high-quality services to teachers who need information, which is beneficial to the library and the school as an organization. The recommendation of this study is that schools should be able to treat librarians as key people in organizing ideas and information resources, rather than as only as academic supporters.
Faktor penyebab rendahnya pemanfaatan jurnal elektronik di Perpustakaan Universitas Gadjah Mada oleh mahasiswa Sekolah Pascasarjana
Authors: Handayani Fitri
Published: June 2021

Introduction. This study aims to examine the inhibiting factors of the use of electronic journals atthe Universitas Gadjah Mada (UGM) Library by UGM graduate school students. The study used Weber's information system model theory with the following variables: system quality, information quality, user training, perceived usefulness, perceived ease of use, computer self-efficacy, information system use, individual impact and information system satisfaction.

Data Collection Methods. This study used  surveys with a quantitative approach. and observations.

Results and Discussion. The results of this study showed that the inhibiting factors of electronic journals at the UGM Library was the difficulties in using information systems electronic journals. This resulted that the students were less confident and rarely to access and utilize electronic journals due to their lack of understanding and skilss in using computers or e-Journal information system.  

Conclusion. The low utilization of the electronic journal is related to the quality of information system (system quality), user perceived difficulties when accessing the electronic journal Information system (perceived easy of use) and the user's ability to use the computer (computer self-efficacy).
Perilaku Maladaptive Anak dan Pengukurannya
Authors: Daulay Nurussakinah
Published: June 2021

Tujuan dari artikel ini adalah berupaya memahami perilaku maladaptive anak dan pengukurannya. Perilaku maladaptive anak merupakan perilaku anak yang tidak mampu menyesuaikan diri atau beradaptasi dengan keadaan sekelilingnya secara wajar, dan tidak mampu beradaptasi sesuai dengan tahapan perkembangan usianya. Permasalahan-permasalahan yang ditimbulkan dari perilaku maladaptive anak dapat menghambat tercapainya perkembangan anak secara optimal. Memahami perilaku maladaptive anak sangat penting untuk meminimalisasi dampak dan tingkat keparahan perilaku. Tulisan ini merupakan reviu literatur. Hasil reviu dalam tulisan ini merupakan bahan rujukan untuk menambah pemahaman terkait konsep perilaku maladaptive anak dan pengukurannya. Perilaku maladaptive anak terbagi dua, yaitu: 1) perilaku maladaptive internalizing, digambarkan seperti ketergantungan, sikap acuh tak acuh, kesulitan makan dan tidur, cemas, perasaan penolakan, perubahan suasana hati, rendahnya kontak mata, kurangnya interaksi sosial; 2) perilaku maladaptive externalizing, dikarakteristikkan seperti perilaku impulsif, tantrum, ketidakpatuhan, tidak peka terhadap orang lain, agresif, keras kepala. Pengukuran untuk menguji perilaku maladaptive anak yang umum digunakan dalam penelitian, diantaranya: 1) Maladaptive Behavior Index-Vineland Adaptive Behavior Scales (MBI-VABS, Sparrow, et al.); 2) Strengths and Difficulties Questionnaire (SDQ, Goodman); dan 3) Child Behavior Checklist (CBCL, Achenbach).
Overcoming Challenges of Education Sector in Indonesia Through Positive Psychology
Authors: Muttaqin Jamalul
Published: June 2021

Challenges of education sector in Indonesia are complex. Literature on Indonesia education has shown these challenges relate to learners, educators, and administrators. We often see, in certain places such as remote areas, poor management of education system from the quality of to human resources. Consequently, this poor education quality led to student’s low motivation and eventually creating the image of education in Indonesia as appeared dreary. This article aims to discuss positive psychology to contextualize challenges of Indonesia’s education. I argue that positive psychology offers insights of overcoming education challenges that might lead to a more joyful educational process. The study is a literature-based research through critical and comprehensive analysis of the phenomenon of education in Indonesia. This research emphasizes that positive psychology works have a very influential space to help achieving welfare of those involve in the education sector. The result offers few recommendations through finding new methods or models of learning that are pleasing that attempt to motivate students to apply positive psychology to improve their quality of life.
Working Memory Vs Inhibitory Control: Peran terhadap Informasi Tidak Relevan sebuah Kajian Neuropsikologi
Authors: Siregar Nani Restati
Published: June 2021

Studi terdahulu melaporkan bahwa working memory (WM) memainkan peran penting dalam mengabaikan informasi tidak relevan sehingga hanya informasi relevan saja yang bekerja pada sistem working memory. Studi lainnya melaporkan bahwa inhibition control (IC) diperlukan untuk menghambat stimulus yang tidak relevan dan menghambat respons yang tidak dihendaki. WM dan IC adalah dua konstrak kognitif yang berbeda dan keduanya memberikan respons pada informasi tidak relevan. Namun, bagaimanakah dinamika kedua konstrak tersebut merespons informasi tidak relevan? Studi literatur kali ini bermaksud untuk menguraikan: (a) konsep mengenai working memory (WM) dan inhibitory control (IC); (b) mekanisme neural pada informasi yang tidak relevan; (c) mekanisme neural working memory dan inhibitory control pada informasi yang tidak relevan. Studi literatur ini menyimpulkan bahwa kapasitas working memory dan inhibitory control merupakan mekanisme kontrol kognitif terhadap informasi tidak relevan. Prefrontal cortex pada otak teraktivasi ketika working memory dan inhibitory control merespons informasi tidak relevan. Namun, working memory hanya menandai atau mengabaikan informasi tidak relevan sementara inhibitory control menghambat informasi tidak relevan. Inhibitory control memperkuat dan meningkatkan kinerja working memory ketika informasi tidak relevan tidak hanya cukup untuk diabaikan saja.
The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article
Authors: Romaniyanto Romaniyanto , Prakoeswa Cita Rosita Sigit , Tinduh Damayanti , Notobroto Hari Basuki , Rantam Fedik Abdul , Utomo Dwikora Novembri , Suroto Heri , Ferdiansyah Ferdiansyah
Published: June 2021

Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc.
Genetic diversity of local rice varieties (Oryza sativa L.) in Vietnam’s Mekong Delta based on SSR markers and morphological characteristics
Authors: Phuc Tran Huu , Giang Van Quoc , Manh Nguyen Van , Ky Huynh
Published: June 2021

Based on target traits, use of the genetic diversity of rice is beneficial for crop improvement. In this study, 41 rice varieties local to Vietnam’s Mekong Delta were evaluated on the basis of 11 quantitative morphological traits, along with the assessment of genetic diversity according to 50 SSR markers. The actual yield had a significance level of 0.05, while plant height and panicles per square meter had a high significance level of 0.001. Cluster analysis based on 11 quantitative traits also revealed that two were the optimal number of clusters used in this study. The highest polymorphic information content (PIC) value obtained was for RM286 (0.49), with a range of 0.00 to 0.49 and an average PIC of 0.14. Both structure and phylogenetic tree analyses as inferred from 50 SSR markers by the unweighted pair‐group method with arithmetic mean (UPGMA) also indicated that the 41 local rice varieties could be divided into two major groups. This study provides a useful information for Mot bui do cao CM, and Mot bui five varieties for improvements in the yield and intermediate amylose content of local rice‐breeding programs in future, especially for the Mekong Delta region.
Complexity, Conflict, and Uncertainty: Smartphone Use and the Efficacy to Learning on University Students in EFL Classrooms
Authors: Chang Lilian Ya-hui
Published: June 2021

The use of smartphones among university students is like a double-edged sword (Qi, 2019), on the positive side, it can boost academic performance; on the negative side usage (or the restriction of it) can detract from learning. The studies offered seem to create a dichotomy: smartphone use during class is either positive or negative. This paper, however, aims to reveal how students’ smartphone use in the classroom is an intricate, conflicting picture that has several layers of complexity creating a confusing picture for the instructor as to how, when, or why to use smartphones in the classroom. In order to explore Taiwanese university students’ potential conflicting viewpoints on the smartphone uses during class time, this study collects both quantitative and qualitative data for data analysis. All the questionnaire respondents used their smartphones during class time. The main reason they do so is due to learning purposes (e.g., check English words online, participate in class activities). However, it is interesting to note that the most frequent uses for the students are for personal reasons, e.g., check the time, check personal messages. Moreover, quantitative data shows that 2/3 of the participants in this study believed that it is all right to use their smartphone during the class, because being able to check information online aids their learning during the class. On the other hand, about 1/3 of the students believed that cellphone use is a distraction for them during the class. Semi-structured interviews also reveal that the interviewees expressed that they have mixed feelings about the appropriateness of the use of smartphones during class. Hopefully, these data can shed light on how teachers approach students’ smartphone uses policy in class.
PHARMACOECONOMIC EVALUATION OF ANTIDIABETIC THERAPY AT A TERTIARY HEALTH CARE INSTITUTION
Authors: M ANIRUDH , K KARTHIKEYAN
Published: June 2021

Objective: The present study was aimed to estimate the direct cost of pharmacotherapy, laboratory tests, and medical tests incurred by patients, to analyze the health-related quality of life (HRQoL) for diabetic patient with macrovascular complications, to estimate the direct health system costs of treating patients with diabetes, to analyze the drug utilization trend of anti-diabetic therapy, to estimate the annual total direct medical costs of managing patients with diabetes, and to evaluate pharmacoeconomic impact on outcomes or beneficence of diabetic therapy.

Methods: A prospective cross-sectional study at SRM Medical College, Hospital and Research Centre, Kattankulathur – General Medicine Department with a sample size of 200 patients.

Results: During study, 200 diabetic patients were enrolled based on the inclusion and exclusion criteria at SRM Medical College and Hospital. Out of 200 diabetic patients (100%), 83 (41.5%) patients were females, and 117 (58.5%) patients were males. Out of 200 (100%) diabetic patients, 18 (9%) of the patient were within the age group of 20–39 years, 78 (39%) of the patients were within the age range of 40–59, the group with the highest frequency was aged from 60 to 79 with 93 (46.5%) patients while the age group of 80–99 had the lowest frequency of 11 (5.5%) of patients. The patient sample had 14 (7%) type 1 diabetic patients out of which two patients (14.3%) were females and 12 (85.7%) were males. A total of 186 (93%) patients had type 2 diabetes where 81 (43.5%) were females and 105 (56.5%) were males. Drug utilization trend: In the patient sample, anti-diabetic drugs were the most frequently used. Oral and parenteral dosage forms were used which included insulin administration subcutaneously and intravenously together with intravenous fluids to correct cases of hyperglycemia and hypoglycemia. HRQoL is the measure of patient value in terms of impact of disease and its treatment on physical functioning and psychological well-being. Out of 200 patients, 25% had severe problems with mobility.

Conclusion: Diabetes is characterized by a very high-cost burden. Education on the prevention and management of diabetes must be prioritized. It must be provided to the diabetic patients and the society at large. Therefore, it is suggested that health-care providers and policy-makers must put more attention to the factors that result in an increased hospital care. A lower financial burden on patients would greatly increase the treatment compliance, complications, and comorbidity progression. This will result in a reduction of diabetes economic burden on patients, society, and health-care system. Further multicenter studies can be carried out in a larger population in different geographical regions in India or it can be done at a national scale.
CONSCIOUSNESS AND PRECAUTIONARY HABIT RELATING TO COVID-19 INFECTIONS AMONG STUDENTS IN NWAFOR ORIZU COLLEGE OF EDUCATION, NSUGBE
Authors: STELLA NWANKWO NONYELUM
Published: June 2021

Objective: Similar to outbreaks of many other infectious diseases, success in controlling the novel coronavirus infection requires a timely and accurate monitoring of the epidemic. The main objective of the present study is to assess consciousness and precautionary habit relating to COVID-19 infections among students.

Methods: The descriptive survey research design method was used. The researcher formulated two research questions. A self-developed questionnaire was adopted for data collection. The sample size consists of students in Nwafor Orizu College of Education, Nsugbe, selected using purposive random sampling technique, subsequently, thirty copies of the questionnaire were administered by the researcher. Mean and standard deviation were used to analyze the data.

Results: The study showed among other findings that students are conscious about the possibility of the disease transmission by droplets when an infected person cough, sneezes, or speaks. These findings have the vantage of providing the researchers, government, students, policy makers, and government with adequate and correct baseline data on consciousness and precautionary habit relating to COVID-19 infections among students.

Conclusion: Based on the research findings, it was concluded that the world has a long history of successful efforts to prevent or cure widespread infections. The main points in preventing the spread in society are hand hygiene, social distancing, and quarantine. With increased testing capacity, detecting more positive patients in the community will also enable the reduction of secondary cases with stricter quarantine rules.
Conjugated estrogen is an effective option to manage chronic GI bleeding in a patient with atrial fibrillation and end-stage renal disease
Authors: Compton Matthew T , Patel Krupa
Published: June 2021

A clinical decision report appraising:

Livio M, Mannucci PM, Viganò G, Mingardi G, Lombardi R, Mecca G, Remuzzi G. Conjugated estrogens for the management of bleeding associated with renal failure. N Engl J Med. 1986;315:731-735 https://doi.org/10.1056/NEJM198609183151204

for a patient with chronic GI bleeding and complicated pro- and anti-coagulation needs.
ASSESSMENT OF THE IMPACT OF THE PROCEDURE OF CHANGING THE WIDTH OF MEASURING DATA ON THE EFFICIENCY OF THEIR COMPRESSION
Authors:   N.V. Bezdenezhnyh Pacific State University, Bezdenezhnyh N.V. , Ivanov V.E. ,   V.E. Ivanov Pacific State University, Levenets A.V. ,   A.V. Levenets Pacific State University, Chye En Un ,   En Un Chye Pacific State University
Published: June 2021

The paper examines the procedure of data preprocessing before compression, which involves enforced change of the original data width. The influence of such a procedure on the compression efficiency is estimated, the results of the study are presented, that show good perspectives of the proposed ap-proach.
ON THE USE OF HEURISTIC ALGORITHMS IN THE PROBLEMS OF OPTIMAL PARAMET-RIC SYNTHESIS
Authors:   O.V. Abramov Institute of automation & control processes FEB RAS, Abramov O.V. , Lagunova A.D. ,   A.D. Lagunova Institute of Automation and Control Processes
Published: June 2021

The problem of optimal synthesis of engineering systems is considered, with due account for the ran-dom changes in their production and operational parameters. A number of ways and means of creating effective heuristic algorithms for multidimensional search optimization are proposed to solve the emerging problems. The paper focuses on the bat algorithm and the creation of its parallel modifica-tion.
FINDING DEFECTS IN AUTOMATIC CONTROL SYSTEMS BASED ON STRUCTURE SENSITIVITY FUNCTIONS AND ANALYSIS OF INTEGRAL ESTIMATES OF OUTPUT SIGNALS
Authors:   S.V. Shalobanov Pacific State University, Shalobanov S.V. , Shalobanov S.S. ,   S.S. Shalobanov Pacific State University, Aleksandrov A.A. ,   A.A. Aleksandrov Pacific State University
Published: June 2021

The paper presents an algorithm for defects screening in a continuous dynamic system with a depth of up to dynamic block based on the structure sensitivity function and the sign analysis of integral esti-mates of the output signals deviations.
SYNTHESIS AND ANALYSIS OF A STATISTICAL MODEL OF THE DYNAMICS OF TIMES SYSTEMS WITH DISCRETE CONTROL UNDER CONDITIONS OF APRIORI UNCERTAINTY
Authors:   A.V. Lapko Siberian State Aerospace University, Lapko A.V. , Lapko V.A. ,   V.A. Lapko Siberian State Aerospace University, Im S.T. ,   S.T. Im Siberian State Aerospace University, Bakhtina A.V. ,   A.V. Bakhtina Siberian State Aerospace University, Аvdeenok V.L. ,   V.L. Аvdeenok Siberian State Aerospace University, Tuboltsev V.P. ,   V.P. Tuboltsev Siberian State Aerospace University
Published: June 2021

A statistical model of a times system with discrete control is proposed, which is one of the topical are-as of modern decision-making theory. Similar conditions are typical of processing information ob-tained through remote sensing of natural objects. An effective way to solve the emerging problems is to use structural methods of statistical data analysis, when the state of the system is understood as a set of values of random variables with similar properties. Such a definition makes it possible to simplify the task of estimating the states of the system under study using nonparametric image recognition algorithms, which open up the possibility of predicting their time dynamics on the basis of transformation of random variables sets. The study of the properties of the statistical model of the time dynamics of the objects under consideration is carried out. The probability of changing the system macro-states from initial to the final time intervals is used as an efficiency indicator. The asymptotic properties of the mentioned above efficiency indicator are investigated, and the results are compared with the Markov limiting theorem for chain dependences.