bluuebunny/crossref_metadata_2025 huggingface dataset:
In Situ Dendritic Cell Recruitment and T Cell Activation for Cancer Immunotherapy
Authors: Han Joonsu , Bhatta Rimsha , Liu Yusheng , Bo Yang , Wang Hua
Published: August 2022

Cancer immunotherapy has shifted the paradigm for cancer treatment in the past decade, but new immunotherapies enabling the effective treatment of solid tumors are still greatly demanded. Here we report a pore-forming hydrogel-based immunotherapy that enables simultaneous recruitment of dendritic cells and in situ activation of T cells, for reshaping the immunosuppressive tumor microenvironment and amplifying cytotoxic T lymphocyte response. The injectable pore-forming hydrogel composed of porogen-dispersed alginate network can form a macroporous structure upon injection into mice, and enables controlled release of granulocyte-macrophage colony-stimulating factor (GM-CSF), a chemoattractant for recruiting dendritic cells, and epacadostat, an inhibitor of indoleamine 2, 3-dioxygenase for activating T cells. We show that gels loaded with GM-CSF and epacadostat, after peritumoral injection, can recruit massive dendritic cells in situ and activate effector T cells in the tumor tissues, resulting in enhanced frequency and activation status of dendritic cells, reduced numbers of regulatory T (Treg) cells, and increased CD8+/Treg ratios in the tumor microenvironment. This hydrogel-based immunotherapy holds great promise for treating poorly-immunogenic solid tumors.
Bibliometric study of soluble guanylate cyclase stimulators in cardiovascular research based on web of science from 1992 to 2021
Authors: Jia Xiao-Yan , Liu Yong-Ming , Wang Yong-Fei , An Jin-Yang , Peng Ke-Ling , Wang Hua
Published: August 2022

Background: Several studies have shown that soluble guanylate cyclase (sGC) stimulators have cardiovascular (CV) benefits. However, few bibliometric analyses have examined this field systematically. Our study aimed to examine the publications to determine the trends and hotspots in CV research on sGC stimulators.

Methods: Publications on sGC stimulators in CV research were retrieved from the Web of Science Core Collection. VOSviewer and CiteSpace visualization software were used to analyze publication trends, countries (regions) and institutions, journals and cited journals, authors and cited references, as well as keywords.

Results: A total of 1,212 literatures were obtained. From its first appearance in 1992–2021 (based on WOSCC record), the overall volume of publications has shown a gradual increasing trend. Nearly one-third were authored by American scholars, and most were published in Circulation, Circulation Research, and Proceedings of the National Academy of Sciences of the United States of America. Bayer Agency in Germany was the leading driving force, and has a high academic reputation in this field. Stasch JP has published the most related articles and been cited most frequently. Half of the top 10 co-cited references were published in the leading highly co-cited journal Circulation and New England Journal of Medicine. “NO,” “allosteric regulation” and “free radicals” were the focus of previous research, “chronic thromboembolic pulmonary hypertension,” “pulmonary hypertension” and “heart failure” were the main research hotspots. The key words “chronic thromboembolic pulmonary hypertension,” “Pulmonary hypertension,” “preserved ejection fraction” and “heart failure” appeared most recently as research frontiers.

Conclusion: The research in the CV field of sGC stimulators was relatively comprehensive, and there was a close relationship among countries, research institutions and authors, but it is still in the exploratory stage in the treatment of CV disease. At present, most studies focus on the results of clinical trials. sGC stimulators in the treatment of heart failure, especially heart failure with preserved ejection fraction, may be the hotpots and Frontier at present and in the future, and should be closely monitored.
Paeoniflorin alleviates liver injury in hypercholesterolemic rats through the ROCK/AMPK pathway
Authors: Liu Tong , Zhang Ning , Kong Lingya , Chu Sijie , Zhang Ting , Yan Guangdi , Ma Donglai , Dai Jun , Ma Zhihong
Published: August 2022

Paeoniflorin (PF) is the main active component in Paeonia lactiflora Pall, and it has multiple effects. However, the precise mechanism of PF in hypercholesterolemia is unclear. In this study, rats were either fed a high-cholesterol diet (HCD) for 4 weeks to establish the hypercholesterolemic model or administered normal saline or PF (20 mg/kg/day). PF significantly reduced liver weight and the liver index. PF reduced hepatic lipid deposition and inflammation, improved serum lipid metabolism, and significantly inhibited serum and hepatic oxidative stress and the inflammatory response. PF treatment caused a marked decrease in the phosphorylated myosin phosphatase target subunit (p-MYPT)-1, nuclear sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS) levels, and an increase in the low-density lipoprotein receptor (LDLR) and phosphorylated-AMP-activated protein kinase (p-AMPK). Thus, PF could alleviate liver injury in hypercholesterolemic rats, and the specific mechanism may be related to the antioxidant, anti-inflammatory properties, and ROCK/AMPK/SREBP-1c signaling pathway.
Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease
Authors: Behl Tapan , Kaur Dapinder , Sehgal Aayush , Singla Rajeev K. , Makeen Hafiz A. , Albratty Mohammed , Alhazmi Hassan A. , Meraya Abdulkarim M. , Bungau Simona
Published: August 2022

Alzheimer’s disease (AD) is perceived with various pathophysiological characteristics such oxidative stress, senile plaques, neuroinflammation, altered neurotransmission immunological changes, neurodegenerative pathways, and age-linked alterations. A great deal of studies even now are carried out for comprehensive understanding of pathological processes of AD, though many agents are in clinical trials for the treatment of AD. Retinoids and retinoic acid receptors (RARs) are pertinent to such attributes of the disease. Retinoids support the proper functioning of the immunological pathways, and are very potent immunomodulators. The nervous system relies heavily on retinoic acid signaling. The disruption of retinoid signaling relates to several pathogenic mechanisms in the normal brain. Retinoids play critical functions in the neuronal organization, differentiation, and axonal growth in the normal functioning of the brain. Disturbed retinoic acid signaling causes inflammatory responses, mitochondrial impairment, oxidative stress, and neurodegeneration, leading to Alzheimer’s disease (AD) progression. Retinoids interfere with the production and release of neuroinflammatory chemokines and cytokines which are located to be activated in the pathogenesis of AD. Also, stimulating nuclear retinoid receptors reduces amyloid aggregation, lowers neurodegeneration, and thus restricts Alzheimer’s disease progression in preclinical studies. We outlined the physiology of retinoids in this review, focusing on their possible neuroprotective actions, which will aid in elucidating the critical function of such receptors in AD pathogenesis.
Impact of strategy conformity on vaccination behaviors
Authors: An Tianbo , Wang Jingrui , Zhou Bowen , Jin Xing , Zhao Jian , Cui Guanghai
Published: August 2022

In most of the studies focusing on the conformity of voluntary vaccination decisions, the conformity was always directly modeled as a conformity-driven strategy-updating rule. However, the utility of an individual can also be influenced by the group identity or discrimination behaviors associated with strategy conformity in realities. Thus, a novel utility model of the vaccination game is first formulated in which the influence of strategy conformity is considered. Then, we use the spatial evolutionary game theory to study the dynamics of individual vaccination strategies under the influence of strategy conformity on the scale-free network. The results show that moderate strategy conformity and a high herd immunity threshold have a significant positive effect on vaccination behaviors when the initial vaccination fraction is low. Moreover, for a high initial vaccination fraction, the strong strategy conformity and high herd immunity threshold are more conducive to encourage vaccination behavior. To analyze the model sensitivity, experiments are conducted in the small world network and square lattice network. In addition, we performed the sensitivity analysis on vaccination effectiveness. Finally, the generality of strategy conformity effect is investigated when the myopic strategy updating rule is adopted in the whole population. The result shows that vaccination behaviors can also be promoted under the condition of moderate strategy conformity and low initial vaccination fraction.
FERONIA functions through Target of Rapamycin (TOR) to negatively regulate autophagy
Authors: Wang Ping , Clark Natalie M. , Nolan Trevor M. , Song Gaoyuan , Whitham Olivia G. , Liao Ching-Yi , Montes-Serey Christian , Bassham Diane C. , Walley Justin W. , Yin Yanhai , Guo Hongqing
Published: August 2022

FERONIA (FER) receptor kinase plays versatile roles in plant growth and development, biotic and abiotic stress responses, and reproduction. Autophagy is a conserved cellular recycling process that is critical for balancing plant growth and stress responses. Target of Rapamycin (TOR) has been shown to be a master regulator of autophagy. Our previous multi-omics analysis with loss-of-function fer-4 mutant implicated that FER functions in the autophagy pathway. We further demonstrated here that the fer-4 mutant displayed constitutive autophagy, and FER is required for TOR kinase activity measured by S6K1 phosphorylation and by root growth inhibition assay to TOR kinase inhibitor AZD8055. Taken together, our study provides a previously unknown mechanism by which FER functions through TOR to negatively regulate autophagy.
Genome-Wide Characterization of Ascorbate Peroxidase Gene Family in Peanut (Arachis hypogea L.) Revealed Their Crucial Role in Growth and Multiple Stress Tolerance
Authors: Raza Ali , Sharif Yasir , Chen Kun , Wang Lihui , Fu Huiwen , Zhuang Yuhui , Chitikineni Annapurna , Chen Hua , Zhang Chong , Varshney Rajeev K. , Zhuang Weijian
Published: August 2022

Ascorbate peroxidase (APX), an important antioxidant enzyme, plays a significant role in ROS scavenging by catalyzing the decrease of hydrogen peroxide under various environmental stresses. Nevertheless, information about the APX gene family and their evolutionary and functional attributes in peanut (Arachis hypogea L.) was not reported. Therefore, a comprehensive genome-wide study was performed to discover the APX genes in cultivated peanut genome. This study identified 166 AhAPX genes in the peanut genome, classified into 11 main groups. The gene duplication analysis showed that AhAPX genes had experienced segmental duplications and purifying selection pressure. Gene structure and motif investigation indicated that most of the AhAPX genes exhibited a comparatively well-preserved exon-intron pattern and motif configuration contained by the identical group. We discovered five phytohormones-, six abiotic stress-, and five growth and development-related cis-elements in the promoter regions of AhAPX. Fourteen putative ah-miRNAs from 12 families were identified, targeting 33 AhAPX genes. Furthermore, we identified 3,257 transcription factors from 38 families (including AP2, ARF, B3, bHLH, bZIP, ERF, MYB, NAC, WRKY, etc.) in 162 AhAPX genes. Gene ontology and KEGG enrichment analysis confirm the role of AhAPX genes in oxidoreductase activity, catalytic activity, cell junction, cellular response to stimulus and detoxification, biosynthesis of metabolites, and phenylpropanoid metabolism. Based on transcriptome datasets, some genes such as AhAPX4/7/17/77/82/86/130/133 and AhAPX160 showed significantly higher expression in diverse tissues/organs, i.e., flower, leaf, stem, roots, peg, testa, and cotyledon. Likewise, only a few genes, including AhAPX4/17/19/55/59/82/101/102/137 and AhAPX140, were significantly upregulated under abiotic (drought and cold), and phytohormones (ethylene, abscisic acid, paclobutrazol, brassinolide, and salicylic acid) treatments. qRT-PCR-based expression profiling presented the parallel expression trends as generated from transcriptome datasets. Our discoveries gave new visions into the evolution of APX genes and provided a base for further functional examinations of the AhAPX genes in peanut breeding programs.
Genome-wide identification of myeloblastosis gene family and its response to cadmium stress in Ipomoea aquatica
Authors: Liu Zheng , Zhang Yuxin , Altaf Muhammad Ahsan , Hao Yuanyuan , Zhou Guangzhen , Li Xinyu , Zhu Jie , Ma Wuqiang , Wang Zhiwei , Bao Wenlong
Published: August 2022

The myeloblastosis (MYB) proteins perform key functions in mediating cadmium (Cd) tolerance of plants. Ipomoea aquatica has strong adaptability to Cd Stress, while the roles of the I. aquatica MYB gene family with respect to Cd stress are still unclear. Here, we identified a total of 183 MYB genes in the I. aquatica genome (laMYB), which were classified into 66 1R-type IaMYB, 112 2R-type IaMYB, four 3R-type IaMYB, and one 4R-type IaMYB based on the number of the MYB repeat in each gene. The analysis of phylogenetic tree indicated that most of IaMYB genes are associated with the diverse biological processes including defense, development and metabolism. Analysis of sequence features showed that the IaMYB genes within identical subfamily have the similar patterns of the motif distributions and gene structures. Analysis of gene duplication events revealed that the dispersed duplication (DSD) and whole-genome duplication (WGD) modes play vital roles in the expansion of the IaMYB gene family. Expression profiling manifests that approximately 20% of IaMYB genes had significant role in the roots of I. aquatica under Cd stress. Promoter profiling implied that the differentially expressed genes might be induced by environmental factors or inherent hormones and thereby execute their function in Cd response. Remarkably, the 2R-type IaMYB157 with abundant light-responsive element G-box and ABA-responsive element ABRE in its promoter region exhibited very strong response to Cd stress. Taken together, our findings provide an important candidate IaMYB gene for further deciphering the molecular regulatory mechanism in plant with respect to Cd stress.
Antinutritional factors, nutritional improvement, and future food use of common beans: A perspective
Authors: Cominelli Eleonora , Sparvoli Francesca , Lisciani Silvia , Forti Chiara , Camilli Emanuela , Ferrari Marika , Le Donne Cinzia , Marconi Stefania , Juan Vorster Barend , Botha Anna-Maria , Marais Diana , Losa Alessia , Sala Tea , Reboul Emmanuelle , Alvarado-Ramos Katherine , Waswa Boaz , Ekesa Beatrice , Aragão Francisco , Kunert Karl
Published: August 2022

Common bean seeds are an excellent source of protein as well as of carbohydrates, minerals, vitamins, and bioactive compounds reducing, when in the diet, the risks of diseases. The presence of bioactive compounds with antinutritional properties (e.g., phytic acid, lectins, raffinosaccharides, protease inhibitors) limits, however, the bean’s nutritional value and its wider use in food preparations. In the last decades, concerted efforts have been, therefore, made to develop new common bean genotypes with reduced antinutritional compounds by exploiting the natural genetic variability of common bean and also applying induced mutagenesis. However, possible negative, or positive, pleiotropic effects due to these modifications, in terms of plant performance in response to stresses or in the resulting technological properties of the developed mutant genotypes, have yet not been thoroughly investigated. The purpose of the perspective paper is to first highlight the current advances, which have been already made in mutant bean characterization. A view will be further provided on future research directions to specifically explore further advantages and disadvantages of these bean mutants, their potential use in innovative foods and representing a valuable genetic reservoir of combinations to assess the true functional role of specific seed bioactive components directly in the food matrix.
CortexVR: Immersive analysis and training of cognitive executive functions of soccer players using virtual reality and machine learning
Authors: Krupitzer Christian , Naber Jens , Stauffert Jan-Philipp , Mayer Jan , Spielmann Jan , Ehmann Paul , Boci Noel , Bürkle Maurice , Ho André , Komorek Clemens , Heinickel Felix , Kounev Samuel , Becker Christian , Latoschik Marc Erich
Published: August 2022

Goal

This paper presents an immersive Virtual Reality (VR) system to analyze and train Executive Functions (EFs) of soccer players. EFs are important cognitive functions for athletes. They are a relevant quality that distinguishes amateurs from professionals.

Method

The system is based on immersive technology, hence, the user interacts naturally and experiences a training session in a virtual world. The proposed system has a modular design supporting the extension of various so-called game modes. Game modes combine selected game mechanics with specific simulation content to target particular training aspects. The system architecture decouples selection/parameterization and analysis of training sessions via a coaching app from an Unity3D-based VR simulation core. Monitoring of user performance and progress is recorded by a database that sends the necessary feedback to the coaching app for analysis.

Results

The system is tested for VR-critical performance criteria to reveal the usefulness of a new interaction paradigm in the cognitive training and analysis of EFs. Subjective ratings for overall usability show that the design as VR application enhances the user experience compared to a traditional desktop app; whereas the new, unfamiliar interaction paradigm does not negatively impact the effort for using the application.

Conclusion

The system can provide immersive training of EF in a fully virtual environment, eliminating potential distraction. It further provides an easy-to-use analyzes tool to compare user but also an automatic, adaptive training mode.
Nurse champions as street-level bureaucrats: Factors which facilitate innovation, policy making, and reconstruction
Authors: Sperling Daniel , Shadmi Efrat , Drach-Zahavy Anat , Luz Shirly
Published: August 2022

Background

Nurse champions are front-line practitioners who implement innovation and reconstruct policy.

Purpose

To understand through a network theory lens the factors that facilitate nurse champions’ engagement with radical projects, representing their actions as street-level bureaucrats (SLBs).

Materials and methods

A personal-network survey was employed. Ninety-one nurse champions from three tertiary medical centers in Israel participated.

Findings

Given high network density, high levels of advice play a bigger role in achieving high radicalness compared with lower levels advice. High network density is also related to higher radicalness when networks have high role diversity.

Discussion

Using an SLB framework, the findings suggest that nurse champions best promote adoption of innovation and offer radical changes in their organizations through professional advice given by colleagues in their field network. Healthcare organizations should establish the structure and promote the development of dense and heterogeneous professional networks to realize organizations’ goals and nurses’ responsibility to their professional employees, patients, and society.
Hope and life satisfaction among Chinese shadow education tutors: The mediating roles of positive coping and perceived social support
Authors: Ji Jie , Zhou Linzhi , Wu Yunpeng , Zhang Mohan
Published: August 2022

Previous studies of the relationship between hope and life satisfaction left the underlying mechanism of how hope predicts life satisfaction unexplored to scholars. This study thus investigates the two potential mediators in the relationship between hope and life satisfaction among a sample of Chinese shadow education institution (SEI) tutors who may be under immense professional development pressure from a cross-sectional approach. The main body of the study consists of an online survey in which 221 SEI tutors reported their hope, positive coping, perceived social support, and life satisfaction. The survey results were analyzed using mediation and moderation analysis via SPSS 23.0. The results indicated that positive coping improved the relationship between hope and life satisfaction, supporting the hypothesis regarding the serial mediating effect of positive coping and perceived social support. In other words, tutors with a high level of hope tend to adopt positive coping strategies, thus will receive more social support and improve life satisfaction. Our findings revealed the independent and accumulative mediating effects of positive coping and perceived social support on the relationship between hope and life satisfaction, and had implications for the psychological intervention of SEI tutors who are currently facing enormous industry pressure.
The challenge of neuropsychological assessment of visual/visuo-spatial memory: A critical, historical review, and lessons for the present and future
Authors: Diaz-Orueta Unai , Rogers Bronagh M. , Blanco-Campal Alberto , Burke Teresa
Published: August 2022

A proliferation of tests exists for the assessment of auditory-verbal memory processes. However, from a clinical practice perspective, the situation is less clear when it comes to the ready availability of reliable and valid tests for the evaluation of visual/visuo-spatial memory processes. While, at face value, there appear to be a wide range of available tests of visual/visuo-spatial memory, utilizing different types of materials and assessment strategies, a number of criticisms have been, and arguably should be, leveled at the majority of these tests. The criticisms that have been directed toward what are typically considered to be visual/visuo-spatial memory tests, such as (1) the potential for verbal mediation, (2) over-abstraction of stimuli, (3) the requirement of a drawing response, and (4) the lack of sensitivity to unilateral brain lesions, mean that, in reality, the number of readily available valid tests of visual/visuo-spatial memory is, at best, limited. This article offers a critical, historical review on the existing measures and resources for the neuropsychological assessment of visual/visuo-spatial memory, and it showcases some examples of newer tests that have aimed to overcome the challenges of assessing these important aspects of memory. The article also identifies new trends and examples of how technological advances such as virtual reality may add value to overcome previous obstacles to assessment, thereby offering professionals more reliable, accurate means to evaluate visual/visuo-spatial memory in clinical practice.
Adaptation to Spanish of the “Relational Needs Satisfaction Scale”: Translation and psychometric testing
Authors: Iraurgi Ioseba , Gómez-Marroquín Ignacio , Erskine Richard , Mauriz Amaia , Martínez-Rodríguez Silvia , Gorbeña Susana , Žvelc Gregor
Published: August 2022

This article aims to adapt to Spanish the Relational Needs Satisfaction Scale (RNSS) and to test the factor structure with a clinical and a non-clinical sample. A total of 459 individuals completed the RNSS, a measure of life satisfaction and of psychological wellbeing. Results showed that the translation was adequate. An exploratory and confirmatory factor analysis was conducted followed by the test of three models that confirmed the five-factor structure and the second-order global factor proposed in the original study, and in adaptations to other languages. The advantages and disadvantages of these models are discussed. Correlations of the RNSS with life satisfaction and psychological wellbeing measures were in the expected direction, providing evidence of convergent validity. The Spanish version of the RNSS is a valid and reliable measure of the construct it was intended to measure, though some improvements in item wording could be incorporated and tested (for instance, item 18 should be positively worded as the rest of the items in order to avoid the effect of negative wording).
Depression is differentially related to cognitive and biomarker outcomes among Mexican Americans
Authors: O’Bryant Sid E. , Petersen Melissa , Hall James , Johnson Leigh A.
Published: August 2022

Introduction

Despite tremendous advancements in the research of Alzheimer’s disease (AD), Mexican Americans, who reflect 65% of the US Hispanic community, remain severely underrepresented in research. Our data demonstrate that risk factors for, and biomarkers of, AD are different among Mexican Americans as compared with non-Hispanic whites. Here, we examined the impact of depressive symptoms on cognitive and AD-relevant biomarker outcomes among the Mexican Americans.

Methods

Data were examined from 1,633 (852 Mexican Americans and 781 non-Hispanic whites) of the Health and Aging Brain Study–Health Disparities (HABS–HD). Depression was assessed using the Geriatric Depression Scale while cognition was measured using detailed neuropsychological testing. Plasma biomarkers of Aβ40, Aβ42, total tau, and NfL were examined in addition to MRI-based neurodegeneration. PET amyloid data were available in a subset of participants.

Results

Depressive symptoms were significantly associated with cognitive testing results among both Mexican Americans and non-Hispanic whites. However, depression was only significantly associated with cognitive outcomes and plasma biomarkers among the Mexican American APOEε4 non-carriers.

Discussion

Depressive symptoms are more commonly endorsed by Mexican Americans and these symptoms are more strongly associated with cognitive and AD-biomarker outcomes among this ethnic group. However, depression scores were only related to AD outcomes among APOEε4 non-carriers within the Mexican American group. These findings can aid in the development of a population-informed precision medicine for treating and preventing cognitive loss among the Mexican Americans.
Twelve-month outcomes in overweight/obese users with mental disorders following a multi-element treatment including diet, physical activity, and positive thinking: The real-world “An Apple a Day” controlled trial
Authors: Giusti Laura , Bianchini Valeria , Aggio Annalisa , Mammarella Silvia , Salza Anna , Necozione Stefano , Alunno Alessia , Ferri Claudio , Casacchia Massimo , Roncone Rita
Published: August 2022

The present study aimed to evaluate the 12-month effectiveness of a real-world weight loss transdiagnostic intervention in overweight/obese participants affected by mental disorders under psychopharmacological treatment. We conducted a real-world, controlled, pragmatic outpatient trial. We allocated 58 overweight/obese adults under psychopharmacological treatment from a mental health outpatient unit and 48 overweight/obese adults from a cardiovascular prevention outpatient unit, and assigned them to an intervention or treatment usual as condition (TAU) enriched by life-style advice. Participants in both intervention groups took part in a diet programme (the modified OMNIHeart dietary protocol) and monitoring of regular aerobic activity. A brief group programme (“An Apple a Day” Metacognitive Training, Apple-MCT) was added in the intervention group of participants affected by mental disorders. The primary outcome was weight loss. Secondary outcomes included anthropometric, clinical, and metabolic variables. Psychopathology and health-related quality of life were also evaluated in the psychiatric sample. At 12 months, both intervention groups showed a more marked mean decrease in weight (6.7 kg, SD: 3.57) than the TAU group (0.32 kg, SD: 1.96), and a statistically significant improvement in metabolic variables compared with the control groups. Furthermore, the participants affected by mental disorders included in the intervention group reported improved health-related quality of life. Our findings suggest the need to implement integrated interventions based on a dietary protocol, physical activity, and modification of cognitive style in overweight/obese users with mental disorders.
Mediating pathways of neuroticism and social anxiety in the relationship between childhood trauma and the fear of missing out among Chinese college students
Authors: Shi Jiale , Li Wei , Han Chengwen , Han Jingying , Pan Fang
Published: August 2022

Recent research has identified various risk factors for fear of missing out. However, studies on the potential influence of childhood trauma on the fear of missing out remain scarce, and little is known regarding the mediating mechanisms underlying this relationship. In this study, we examine the predictive role of childhood trauma on the fear of missing out among college students and investigate whether neuroticism and social anxiety mediate the relationship between childhood trauma and the fear of missing out. A sample of 1,266 Chinese college students completed questionnaires regarding childhood trauma, neuroticism, social anxiety, and the fear of missing out. The results indicated that (a) childhood trauma is positively associated with the fear of missing out, (b) both neuroticism and social anxiety mediate the relationship between childhood trauma and the fear of missing out, and (c) neuroticism and social anxiety sequentially mediate the relationship between childhood trauma and the fear of missing out. These findings have crucial implications for the prevention and intervention of the fear of missing out among college students.
Development of a culturally adaptable internet-based cognitive behavioral therapy for Japanese women with bulimia nervosa
Authors: Hamatani Sayo , Matsumoto Kazuki , Ishibashi Tomoaki , Shibukawa Ryunosuke , Honda Yuki , Kosaka Hirotaka , Mizuno Yoshifumi , Andersson Gerhard
Published: August 2022

Background

The process of cultural adaptation of internet-based cognitive behavioral therapy (ICBT) programs for bulimia nervosa (BN) have rarely been reported despite the potential influence of cultural adaptation of psychosocial interventions on therapeutic response.

Aim

This study aimed to illustrate development process of an ICBT program for Japanese women with bulimia nervosa (BN).

Methods

A mixed methods approach was used to assess cultural adaptation of the prototype of an original ICBT program by using the Cultural Relevance Questionnaire (CRQ). Five women with BN and seven clinicians were interviewed using the CRQ.

Results

Quantitative analyses were conducted to assess cultural adaptation of the prototype of the program and participants rated cultural adaptation as high. A qualitative analysis of the mixed method supported the culturally sensitive changes implemented.

Conclusions

The results of this study show that a series of processes can make ICBT programs more culturally adapted.
Development and validation of cultural competence assessment tool for healthcare professionals, India
Authors: Balachandran Parvathy , Karuveettil Vineetha , Janakiram Chandrashekar
Published: August 2022

Culture influences an individual's perception of “health” and “sickness”. Therefore, cultural competence assessment of healthcare professionals is very important. Existing assessment scales have limited application in India due to the nation's rich cultural diversity and heterogeneous healthcare streams. This study was undertaken to develop and validate a cultural competence assessment tool for healthcare professionals in India. A cross-sectional study using convenience sampling was conducted following all standard steps among 290 healthcare professionals in India. Item reduction was followed by estimation of validity and reliability. Responses were recorded on a five-point Likert scale, ranging from strongly disagree to strongly agree. The resultant tool, named Cultural Competence Assessment Tool–India (CCT-I) showed an acceptable internal consistency (Cronbach's alpha =0.734). Inter-rater agreement was 81.43%. Face, content, and construct validity were demonstrated. There was no statistically significant difference in cultural competence between the healthcare streams based on years of clinical experience. There was statistically significant difference between streams of healthcare (p-value =0.009) and also between dentistry and Ayurveda groups (p-value = 0.003). This comprehensive tool can be used as the first step toward designing cultural competence training of healthcare manpower and the establishment of culturally sensitive healthcare organizations.
The effect of a short, animated story-based video on COVID-19 vaccine hesitancy: A study protocol for an online randomized controlled trial
Authors: Barteit Sandra , Hachaturyan Violetta , Beleites Ferdinand , Kühn Tilman , Favaretti Caterina , Adam Maya , Bärnighausen Till
Published: August 2022

Introduction

Exposure to a high volume of vaccine misinformation on social media can have a negative effect on vaccine confidence and rates. To counteract misinformation, we designed a collage of three short, animated story-based (SAS) videos to convey scientifically informed and accessible information about COVID-19 vaccine applicable to a social media context.

Methods and analysis

We will conduct an online randomized controlled trial primarily to: (1) determine the effectiveness of SAS videos in improving COVID-19 vaccine knowledge; (2) evaluate the effectiveness of SAS videos in increasing behavioral intent for COVID-19 vaccination; and (3) quantify people's interest in watching SAS videos about the COVID-19 vaccine. We also aim to identify barriers and facilitators to COIVD-19 vaccinations that have been shown to minimize vaccine hesitancy between vaccinated and unvaccinated populations. Using a web-based recruitment platform, a total of 10,000 adults from the United States will be recruited and randomly assigned to (1) a SAS video collage arm, (2) an attention placebo control video arm, or (3) no intervention arm (1:1:1). Furthermore, we will measure behavioral intent to obtain information on vaccination regarding COVID-19. At the end of the trial, participants randomized to arm 2 and arm 3 will be given the option of watching one of the intervention videos voluntarily to assess participant engagement with SAS videos. Finally, we will assess individual factors associated with vaccine hesitancy - hope, optimism, COVID-19 perceived risks and benefits, self-efficacy, perceived social norms, and trust - and compare vaccinated and unvaccinated participants across the three arms.

Discussions

Evidence-based information from official channels can be complex and inaccessible to the general public, whereas false information on social media is frequently shared in brief postings, images, or videos that can easily reach the general public, thereby rapidly disseminating (mis-)information. To avoid the spread of misinformation, social media may be used to deliver evidence-based and emotionally compelling information in a readily accessible format in order to pre-empt misinformation. Our findings may help inform future SAS efforts addressing COVID-19 and other important public health challenges.

Ethics and dissemination

The study was approved by the Heidelberg University Hospital's Ethics Committee (S-163/2022). The trial was registered with German Clinical Trials Register (www.drks.de) on 5 January 2022: number DRKS00027938. Findings of the study will be published in peer-reviewed scientific publications and possibly presented at scientific conferences.
From Walking to Running: 3D Humanoid Gait Generation via MPC
Authors: Smaldone Filippo M. , Scianca Nicola , Lanari Leonardo , Oriolo Giuseppe
Published: August 2022

We present a real time algorithm for humanoid 3D walking and/or running based on a Model Predictive Control (MPC) approach. The objective is to generate a stable gait that replicates a footstep plan as closely as possible, that is, a sequence of candidate footstep positions and orientations with associated timings. For each footstep, the plan also specifies an associated reference height for the Center of Mass (CoM) and whether the robot should reach the footstep by walking or running. The scheme makes use of the Variable-Height Inverted Pendulum (VH-IP) as a prediction model, generating in real time both a CoM trajectory and adapted footsteps. The VH-IP model relates the position of the CoM to that of the Zero Moment Point (ZMP); to avoid falling, the ZMP must be inside a properly defined support region (a 3D extension of the 2D support polygon) whenever the robot is in contact with the ground. The nonlinearity of the VH-IP is handled by splitting the gait generation into two consecutive stages, both requiring to solve a quadratic program. Thanks to a particular triangular structure of the VH-IP dynamics, the first stage deals with the vertical dynamics using the Ground Reaction Force (GRF) as a decision variable. Using the prediction given by the first stage, the horizontal dynamics become linear time-varying. During the flight phases, the VH-IP collapses to a free-falling mass model. The proposed formulation incorporates constraints in order to maintain physically meaningful values of the GRF, keep the ZMP in the support region during contact phases, and ensure that the adapted footsteps are kinematically realizable. Most importantly, a stability constraint is enforced on the time-varying horizontal dynamics to guarantee a bounded evolution of the CoM with respect to the ZMP. Furthermore, we show how to extend the technique in order to perform running on tilted surfaces. We also describe a simple technique that receives input high-level velocity commands and generates a footstep plan in the form required by the proposed MPC scheme. The algorithm is validated via dynamic simulations on the full-scale humanoid robot HRP-4, as well as experiments on the small-sized robot OP3.
Spatial up-sampling of HRTF sets using generative adversarial networks: A pilot study
Authors: Siripornpitak Pongsakorn , Engel Isaac , Squires Isaac , Cooper Samuel J. , Picinali Lorenzo
Published: August 2022

Headphones-based spatial audio simulations rely on Head-related Transfer Functions (HRTFs) in order to reconstruct the sound field at the entrance of the listener’s ears. A HRTF is strongly dependent on the listener’s specific anatomical structures, and it has been shown that virtual sounds recreated with someone else’s HRTF result in worse localisation accuracy, as well as altering other subjective measures such as externalisation and realism. Acoustic measurements of the filtering effects generated by ears, head and torso has proven to be one of the most reliable ways to obtain a personalised HRTF. However this requires a dedicated and expensive setup, and is time-intensive. In order to simplify the measurement setup, thereby improving the scalability of the process, we are exploring strategies to reduce the number of acoustic measurements without degrading the spatial resolution of the HRTF. Traditionally, spatial up-sampling of HRTF sets is achieved through barycentric interpolation or by employing the spherical harmonics framework. However, such methods often perform poorly when the provided HRTF data is spatially very sparse. This work investigates the use of generative adversarial networks (GANs) to tackle the up-sampling problem, offering an initial insight about the suitability of this technique. Numerical evaluations based on spectral magnitude error and perceptual model outputs are presented on single spatial dimensions, therefore considering sources positioned only in one of the three main planes: Horizontal, median, and frontal. Results suggest that traditional HRTF interpolation methods perform better than the proposed GAN-based one when the distance between measurements is smaller than 90°, but for the sparsest conditions (i.e., one measurement every 120°–180°), the proposed approach outperforms the others.
Instantaneous effects of mindfulness meditation on tennis return performance in elite junior athletes completing an implicitly sequenced serve return task
Authors: O'Connor Edward J. , Murphy Alistair , Kohler Mark J. , Chan Russell W. , Immink Maarten A.
Published: August 2022

Single-session meditation augmentation of sport-specific skill performance was tested with elite junior tennis athletes. Athletes completed one of two styles of mindfulness meditation (focused-attention or open-monitoring) or a control listening condition prior to performing an implicitly sequenced tennis serve return task involving the goal of hitting a target area placed on the service court. Unbeknownst to athletes, six distinct serves followed a repeating second-order conditional sequence for two task blocks before the sequence was altered in a third transfer block. Task performance was operationalized as serve return outcome and analyzed using beta regression modeling. Models analyzed group by block differences in the proportion of returned serves (i.e., non-aces), returns placed in the service court, and target hits. Contrary to previous laboratory findings, results did not support meditation-related augmentation of performance and/or sequence learning. In fact, compared to control, meditation may have impaired performance improvements and acquisition of serve sequence information. It is possible that the effects of single-session meditation seen in laboratory research may not extend to more complex motor tasks, at least in highly-trained adolescents completing a well-learned skill. Further research is required to elucidate the participant, task, and meditation-related characteristics that might promote single-session meditation performance enhancement.
A novel web-based dynamic nomogram for recurrent laryngeal nerve lymph node metastasis in esophageal squamous cell carcinoma
Authors: Chen Ting-Ting , Yan Hao-Ji , He Xi , Fu Si-Yi , Zhang Sheng-Xuan , Yang Wan , Zuo Yu-Jie , Tang Hong-Tao , Yang Jun-Jie , Liu Pei-Zhi , Wen Hong-Ying , Tian Dong
Published: August 2022

Background

Patients with esophageal squamous cell carcinoma (ESCC) are liable to develop recurrent laryngeal nerve (RLN) lymph node metastasis (LNM). We aimed to assess the predictive value of the long diameter (LD) and short diameter (SD) of RLN lymph node (LN) and construct a web-based dynamic nomogram for RLN LNM prediction.

Methods

We reviewed 186 ESCC patients who underwent RLN LN dissection from January 2016 to December 2018 in the Affiliated Hospital of North Sichuan Medical College. Risk factors for left and right RLN LNM were determined by univariate and multivariate analyses. A web-based dynamic nomogram was constructed by using logistic regression. The performance was assessed by the area under the curve (AUC) and Brier score. Models were internally validated by performing five-fold cross-validation.

Results

Patients who underwent left and right RLN LN dissection were categorized as left cohort (n = 132) and right cohort (n = 159), with RLN LNM rates of 15.9% (21/132) and 21.4% (34/159), respectively. The AUCs of the LD (SD) of RLN LN were 0.663 (0.688) in the left cohort and 0.696 (0.705) in the right cohort. The multivariate analysis showed that age, the SD of RLN LN, and clinical T stage were significant risk factors for left RLN LNM (all P < 0.05), while tumor location, the SD of RLN LN, and clinical T stage were significant risk factors for right RLN LNM (all P < 0.05). The dynamic nomograms showed reliable performance after five-fold cross-validation [(left (right), mean AUC: 0.814, range: 0.614–0.891 (0.775, range: 0.084–0.126); mean Brier score: 0.103, range: 0.084–0.126 (0.145, range: 0.105–0.206)], available at https://mpthtw.shinyapps.io/leftnomo/ and https://mpthtw.shinyapps.io/rightnomo/.

Conclusion

The LD and SD of RLN LN are inadequate to predict RLN LNM accurately, but online dynamic nomograms by combined risk factors show better prediction performance and convenient clinical application.
A potential herbal therapeutic for trichinellosis
Authors: El-kady Asmaa M. , Abdel-Rahman Iman A. M. , Sayed Eman , Wakid Majed H. , Alobaid Hussah M. , Mohamed Khalil , Alshehri Eman Abdullah , Elshazly Hayam , Al-Megrin Wafa Abdullah I. , Iqbal Furhan , Elshabrawy Hatem A. , Timsah Ashraf G.
Published: August 2022

Background

Trichinellosis is a helminthic disease caused byTrichinella spiralis viathe ingestion of raw or undercooked meat of infected animals. Current estimates indicate that 11 million humans have trichinellosis, worldwide. The effective use of anti-trichinella medications is limited by side effects and resistance which highlight the critical need for safe and effective drugs, particularly those derived from medicinal plants. Therefore, in the present study, we aimed to evaluate the efficacy of the ethanolic extract ofArtemisia annua(A. annua) in treatment of experimentally induced trichinellosis.

Materials and methods

Trichinellosis was induced experimentally in male 6–8 weeks BALB/c mice. BALB/c mice were divided into four groups, 10 mice each. One group was left uninfected and untreated, whereas three groups were infected withT. spiralis. Oneinfected group of mice was left untreated (negative control) while the remaining two infected groups received either 300 mg/kg of the ethanolic extract ofA. annuaor 50 mg/kg of albendazole (positive control). All treatments started from the third day post-infection (dpi) for 3 successive days. All animals were sacrificed on the 7th dpi for evaluation of treatment efficacy.

Results

Our findings showed thatA. annuatreatment reduced theT. spiralisadult-worm count in the intestine of infected animals. Moreover, treatment withA. annuarestored the normal intestinal architecture, reduced edema, alleviated inflammation as demonstrated by reduced inflammatory infiltrate and expression of TGF-β in intestinal tissues ofA. annua-treated animals compared to infected untreated animals.

Conclusions

Our findings show thatA. annuaextract is effective in treating experimentally induced trichinellosis which highlight the therapeutic potential ofA. annuafor intestinal trichinellosis.
Evaluation of Russian sturgeon (Acipenser gueldenstaedtii) Semen Quality and Semen Cryopreservation
Authors: Igna Violeta , Telea Ada , Florea Tiana , Popp Roxana , Grozea Adrian
Published: August 2022

The alarming decline in sturgeon populations doubled by growing demands for sturgeon products, urge us to prevent the loss of these species. Fish stocking in natural habitats and developing fish farms are viable solutions, which can be successfully implemented with the help of reproductive biotechnologies. Despite the fact that semen cryopreservation is admittedly an important step for saving the Russian sturgeon, a reproducible standard method with good results has yet to be identified. Sperm quality assessment is essential for quantifying the impact of cryopreservation on spermatozoa. The purpose of our study was to provide additional information regarding semen cryopreservation and semen quality evaluation for the Russian sturgeon. Our study method is based on the use of two yolk-free extenders (with different cryoprotectants: DMSO and methanol) for freezing semen, using a simple freezing protocol. Parameters such as volume, concentration, motility, morphology and membrane integrity were evaluated. In conclusion, cryopreservation of Russian sturgeon spermatozoa using an extender containing methanol as cryoprotectant led to high egg fertilization percentages (72.67 ± 5.4%) even if the total motility values recorded for thawed semen were quite low (18–25%). Additionally, we identified two optimal stains for morphological studies and morphometry (Spermac stain kit and Trypan Blue Solution).