bluuebunny/crossref_metadata_2025 huggingface dataset:
Belgian rare diseases plan in clinical pathology: identification of key biochemical diagnostic tests and establishment of reference laboratories and financing conditions
Authors: Vandevelde Nathalie Monique , Vermeersch Pieter , Devreese Katrien M.J. , Vincent Marie-Françoise , Gulbis Béatrice , Eyskens François , Boemer François , Gothot André , Hoof Viviane O. Van , Bonroy Carolien , Stepman Hedwig , Martens Geert A. , Bossuyt Xavier , Roosens Laurence , Smet Julie , Laeremans Hilde , Weets Ilse , Minon Jean-Marc , Vernelen Kris , Coucke Wim ,   Board of the Action 1 of the Belgian National Plan for Rare Diseases
Published: July 2022

Background: One objective of the Belgian Rare Diseases plan is to improve patients’ management using phenotypic tests and, more specifically, the access to those tests by identifying the biochemical analyses used for rare diseases, developing new financing conditions and establishing reference laboratories.Methods: A feasibility study was performed from May 2015 until August 2016 in order to select the financeable biochemical analyses, and, among them, those that should be performed by reference laboratories. This selection was based on an inventory of analyses used for rare diseases and a survey addressed to the Belgian laboratories of clinical pathology (investigating the annual analytical costs, volumes, turnaround times and the tests unavailable in Belgium and outsourced abroad). A proposal of financeable analyses, financing modalities, reference laboratories’ scope and budget estimation was developed and submitted to the Belgian healthcare authorities. After its approval in December 2016, the implementation phase took place from January 2017 until December 2019.Results: In 2019, new reimbursement conditions have been published for 46 analyses and eighteen reference laboratories have been recognized. Collaborations have also been developed with 5 foreign laboratories in order to organize the outsourcing and financing of 9 analyses unavailable in Belgium. Conclusions: In the context of clinical pathology and rare diseases, this initiative enabled to identify unreimbursed analyses and to meet the most crucial financial needs. It also contributed to improve patients’ management by establishing Belgian reference laboratories and foreign referral laboratories for highly-specific analyses and a permanent surveillance, quality and financing framework for those tests.
Bayesian method for estimating Weibull parameters for wind resource assessment in the Equatorial region: a comparison between two-parameter and three-parameter Weibull distributions
Authors: Khan M. G. M. , Ahmed M. Rafiuddin
Published: July 2022

The two-parameter Weibull distribution has garnered much attention in the assessment of windenergy potential. The estimation of the shape and scale parameters of the distribution has broughtforth a successful tool for the wind energy industry. However, it may be inappropriate to use thetwo-parameter Weibull distribution to assess energy at every location, especially at sites wherelow wind speeds are frequent, such as the Equatorial region. In this work, a robust technique inwind resource assessment using a Bayesian approach for estimating Weibull parameters is firstproposed. Secondly, the wind resource assessment techniques using a two-parameter Weibulldistribution and a three-parameter Weibull distribution which is a generalized form of twoparameterWeibull distribution are compared. Simulation studies confirm that the Bayesianapproach seems a more robust technique for accurate estimation of Weibull parameters. Theresearch is conducted using data from seven sites in Equatorial region from 1o N of Equator to 19oSouth of Equator. Results reveal that a three-parameter Weibull distribution with non-zero shiftparameter is a better fit for wind data having a higher percentage of low wind speeds (0-1 m/s) andlow skewness. However, wind data with a smaller percentage of low wind speeds and highskewness showed better results with a two-parameter distribution that is a special case of threeparameterWeibull distribution with zero shift parameter. The results also demonstrate that theproposed Bayesian approach and application of a three-parameter Weibull distribution areextremely useful in accurate estimate of wind power and annual energy production.
Aplicação clínica da terapia laser na Endodontia
Authors: Simões Thamyres Maria Silva , Catão Maria Helena Chaves de Vasconcelos
Published: July 2022

Introdução: O uso da luz com finalidades terapêuticas tem possibilitado à Odontologia inúmeras aplicações clínicas. Com o desenvolvimento e o constante aperfeiçoamento da terapia com uso do laser, observou-se que esta poderia ser aplicada também à Endodontia, durante e após a realização do tratamento endodôntico convencional, bem como nas cirurgias periapicais. Objetivo: Avaliar, através de uma revisão de literatura, as aplicações clínicas da terapia laser na Endodontia. Material e método: O levantamento literário para esta pesquisa foi realizado entre os meses de outubro e novembro de 2019, através de buscas em publicações científicas indexadas nas bases de dados Scielo e Medline/PubMed. Os estudos foram selecionados a partir de critérios de inclusão preestabelecidos, sendo excluídos os temas divergentes ao objetivo deste estudo, artigos de revisão de literatura, estudos in vitro e ex vivo, estudos utilizando animais e artigos anteriores a 2009. Resultados: Um total de 214 artigos foram encontrados nas bases de dados selecionadas, sendo 19 artigos pré-selecionados e 17 incluídos na presente revisão. Conclusão: A utilização clínica do laser como adjuvante ao tratamento endodôntico convencional, mostrou resultados satisfatórios no que diz respeito ao controle da dor pós-operatória, desinfecção do sistema de canais radiculares, na cirurgia periapical, no reparo tecidual pós-operatório e de tecidos lesados pela extrusão de NaClO. No entanto, a terapia laser deve ser bem indicada e realizada com base em protocolos previamente estabelecidos, para que o cirurgião-dentista possa utilizá-la de forma segura e eficaz.
Dicle Havzasındaki Bazı İstasyonlara ait Potansiyel Evapotranspirasyon Verilerinin Trend Analizi
Authors: KATİPOĞLU Okan Mert
Published: July 2022

Potansiyel evapotranspirasyon (PET) değerlerindeki eğilimlerin belirlenmesi, iklim değişikliği ve kuraklık yönetimi, tarımsal su kaynaklarının daha verimli yönetimi ve sulama planlamasının optimal tasarımı konuları açısından büyük öneme sahiptir. Bu çalışmada Dicle havzasında bulunan Batman, Cizre, Diyarbakır ve Hakkâri meteoroloji istasyonları için, 1964-2017 yılları arasında hesaplanan mevsimsel ve yıllık PET değerlerinin trend analizleri gerçekleştirilmiştir. Trendlerin belirlenmesinde Şen in Yenilikçi Trend Analizi (ITA) ve Mann-Kendall Mertebe Korelasyon (MKMK) metotları kullanılmıştır. PET değerlerinin hesaplanmasında sıklıkla kullanılan, basit ve az veri gerektiren Thornthwaite metodolojisi tercih edilmiştir. Araştırma sonunda ITA yöntemine göre, havzada seçilen istasyonların PET verilerinde genelde istatistik açıdan anlamlı artış trendleri hakimken, Diyarbakır istasyonu için ilkbahar ve kış mevsimlerinde istatistik açıdan anlamlı azalan trendler tespit edilmiştir. MKMK testine göre, kış mevsimi dışında istasyon konumlarında PET değerlerinde anlamlı artışlar vardır. Ayrıca ITA ve MKMK testleri büyük ölçüde örtüşmekle birlikte bazı istasyonlarda ITA ile tespit edilen artış trendleri MKMK testi ile saptanamamıştır. Elde edilen sonuçlar tarımsal su kaynaklarının planlanması ve verimli bir şekilde kullanılmasında, küresel ısınmanın etkileriyle mücadele etmek için adaptasyon ve azaltma stratejileri geliştirilmesinde karar vericilere önemli bilgi temin etmektedir.
Theoretical and Experimental Spectroscopic Study on 2-Chloro-3-(substitutedphenylamino)-1,4-naphthoquinone Derivatives
Authors: Dias Flaviana , Campos Vinícius , de Moraes Raphael , Souza Nelson , Cunha Anna , Lage Mateus , Ferreira Glaucio
Published: July 2022

The 1,4-naphthoquinones are an important group of compounds intensively studied because of their wide range of biological activities. Four 2-chloro-3-(substituted-phenylamino)- 1,4‑naphthoquinone derivatives were synthesized, and the vibrational modes of these molecules were assigned using Raman and Fourier transform infrared spectroscopy (FTIR) techniques. In addition, X-ray studies were performed for one of these derivatives. Density functional theory (DFT) calculations were also developed for these compounds and presented. In summary, the results obtained from these studies can assess chemical changes in the structures of functionalized quinones and the discovery of candidate biologically active compounds.
Nano Clay Reinforcement of Thermoplastics for Engineering Applications
Authors: Santhosh G.
Published: July 2022

Thermoplastics are widely used advanced materials in various fields as an essential product. The increasing interest in replacing thermosets due to their advanced properties such as high toughness, manufacturing time and processing possibilities. Thermoplastics exhibit poor mechanical properties in several engineering applications; hence the use of nano clay minerals enhances the mechanical property of thermoplastics to be used in many engineering applications. The reinforcing effect of clay minerals (nano-clay) in various thermoplastics such as polycarbonate (PC), polypropylene (PP), Acrylonitrile butadiene styrene (ABS) and high-density polyethylene (HDPE), which are popularly known as commodity plastics and are widely used in fabricating automotive parts and household articles. The frequently used clay minerals such as montmorillonite, bentonite, hectorite, halloysites and kaolinite as filler material in thermoplastics make them suitable in many engineering applications with enhanced mechanical properties. The integration of clay minerals into a polymer matrix allows both properties from clay minerals and polymer to be combined so as to exploit entirely new functionalities. In recent years, owing to a number of practical applications in the field of opto-electronics, a great deal of interest has been paid to study optical, dielectric and conduction behaviours of various polymeric materials. This chapter is designed to be a source for nano-clay reinforced thermoplastic nano-composite research including synthesis, characterization, structure/property relationship and applications considering optical and electrical conductivity which are discussed.
From critical manifesto to transformative genderplay: feminist Futurist and Dadaist strategies countering the misogyny within the historical avant-gardes
Authors: Doutreligne Sophie
Published: July 2022

This article touches upon the problematic reception of the female pioneers of the historical avant-gardes - by contemporaries and art historians - more specifically within the movements of Futurism, Dadaism and Surrealism. What artistic strategies did avant-garde women apply to resist the omnipresent misogyny that was not only trivializing female creation but also sexualizing the female ‘other’? How is the gender binary embedded and challenged within their artistic practice?
 
This article observes firstly, how a critical engagement with the rather masculine format of the manifesto empowered women in dealing with the stereotypical imagery of womanhood at the time. Second, the application of so-called “inferior” media (embroidery, design, dance) and materials (textile, wood, the body) tackled the patriarchal classification of the arts and the subordinate role of women in it. Finally, the live performance of genderplay allowed female artists to articulate the bankruptcy of traditional gender conventions responsible for the problematic reception of many female artists through art history.
Speech Processing as a Far-Transfer Gauge of Serious Games for Cognitive Training in Aging: Randomized Controlled Trial of Web-Based Effectivate Training
Authors: Nitsan Gal , Baharav Shai , Tal-Shir Dalith , Shakuf Vered , Ben-David Boaz M
Published: July 2022

Background

The number of serious games for cognitive training in aging (SGCTAs) is proliferating in the market and attempting to combat one of the most feared aspects of aging—cognitive decline. However, the efficacy of many SGCTAs is still questionable. Even the measures used to validate SGCTAs are up for debate, with most studies using cognitive measures that gauge improvement in trained tasks, also known as near transfer. This study takes a different approach, testing the efficacy of the SGCTA—Effectivate—in generating tangible far-transfer improvements in a nontrained task—the Eye tracking of Word Identification in Noise Under Memory Increased Load (E-WINDMIL)—which tests speech processing in adverse conditions.

Objective

This study aimed to validate the use of a real-time measure of speech processing as a gauge of the far-transfer efficacy of an SGCTA designed to train executive functions.

Methods

In a randomized controlled trial that included 40 participants, we tested 20 (50%) older adults before and after self-administering the SGCTA Effectivate training and compared their performance with that of the control group of 20 (50%) older adults. The E-WINDMIL eye-tracking task was administered to all participants by blinded experimenters in 2 sessions separated by 2 to 8 weeks.

Results

Specifically, we tested the change between sessions in the efficiency of segregating the spoken target word from its sound-sharing alternative, as the word unfolds in time. We found that training with the SGCTA Effectivate improved both early and late speech processing in adverse conditions, with higher discrimination scores in the training group than in the control group (early processing: F1,38=7.371; P=.01; ηp2=0.162 and late processing: F1,38=9.003; P=.005; ηp2=0.192).

Conclusions

This study found the E-WINDMIL measure of speech processing to be a valid gauge for the far-transfer effects of executive function training. As the SGCTA Effectivate does not train any auditory task or language processing, our results provide preliminary support for the ability of Effectivate to create a generalized cognitive improvement. Given the crucial role of speech processing in healthy and successful aging, we encourage researchers and developers to use speech processing measures, the E-WINDMIL in particular, to gauge the efficacy of SGCTAs. We advocate for increased industry-wide adoption of far-transfer metrics to gauge SGCTAs.
Challenges in Recruiting University Students for Web-based Indicated Prevention of Depression and Anxiety: Results from a Randomized Controlled Trial (ICare Prevent) (Preprint)
Authors: Bolinski Felix , Kleiboer Annet , Neijenhuijs Koen , Karyotaki Eirini , Wiers Reinout , de Koning Lisa , Jacobi Corinna , Zarski Anna-Carlotta , Weisel Kiona K. , Cuijpers Pim , Riper Heleen
Published: July 2022

BACKGROUND

Depression and anxiety are common mental health conditions in college/ university student populations. Offering transdiagnostic, web-based prevention programs, such as ICare Prevent, to those with subclinical complaints has the potential to reduce some barriers to receiving help, e.g., availability of services, privacy considerations, and students’ desire for autonomy. Accounts of recruitment challenges are needed to complement available effectiveness research in student populations.

OBJECTIVE

The aims of the current study are to describe recruitment challenges together with effective recruitment strategies for ICare Prevent, and to provide basic information on the intervention’s effectiveness.

METHODS

A three-arm randomized controlled trial (RCT) was conducted in a student sample with subclinical symptoms of depression and anxiety on the effectiveness of a guided and unguided version of ICare Prevent, a web-based intervention with transdiagnostic components for the indicated prevention of depression and anxiety compared to care-as-usual (CAU). Descriptive statistics are used to outline recruitment challenges and effective online and offline strategies, as well as students’ use of the intervention. A basic analysis of intervention effects was conducted using a Bayesian linear mixed model.

RESULTS

Direct recruitment through students’ email addresses via the central student administration was the most effective channel. Data of 35 participants were analyzed (guided= 14, unguided= 8, CAU= 13). Use of the intervention was low, with an average of three out of seven sessions completed. Analyses did not suggest any intervention effects other than anecdotal evidence (all BF10≤ 2.7).

CONCLUSIONS

This report adds to the existing literature on recruitment challenges specific to the student population. Testing the feasibility of recruitment measures and greater involvement of the target population in their design, as well as shifting from direct towards indirect prevention can potentially help future studies in the field. In addition, it demonstrates an alternative basic analytical strategy for underpowered RCTs.

CLINICALTRIAL

The trial has been registered at the Dutch trial register (Nederlands Trial Register, NTR6562).

INTERNATIONAL REGISTERED REPORT

RR2-https://doi.org/10.1186/s13063-018-2477-y
A Digital Infrastructure for Cardiovascular Patient Care Based on Mobile Health Data and Patient-Reported Outcomes: Concept Details of the Helios TeleWear Project Including Preliminary Experiences (Preprint)
Authors: Leiner Johannes , König Sebastian , Mouratis Konstantinos , Kim Igor , Schmitz Pia , Joshi Tanvi , Schanner Carolin , Wohlrab Lisa , Hohenstein Sven , Pellissier Vincent , Nitsche Anne , Kuhlen Ralf , Hindricks Gerhard , Bollmann Andreas
Published: July 2022

BACKGROUND

Mobile health (mHealth) approaches are already having a fundamental impact on clinical practice in cardiovascular medicine. A variety of different health apps and wearable devices for capturing health data such as electrocardiograms (ECGs) exist. However, most mHealth technologies focus on distinct variables without integrating patients’ quality of life, and the impact on clinical outcome measures of implementing those digital solutions into cardiovascular health care is still to be determined.

OBJECTIVE

Within this document, we describe the TeleWear project, which was recently initiated as an approach for contemporary patient management integrating mobile-collected health data and the standardized mHealth-guided measurement of patient-reported outcomes (PROs) in patients with cardiovascular disease.

METHODS

The specifically designed mobile app and clinical frontend form the central elements of our TeleWear infrastructure. Because of its flexible framework, the platform allows far-reaching customization with the possibility to add different mHealth data sources and respective questionnaires (patient-reported outcome measures).

RESULTS

With initial focus on patients with cardiac arrhythmias, a feasibility study is currently carried out to assess wearable-recorded ECG and PRO transmission and its evaluation by physicians using the TeleWear app and clinical frontend. First experiences made during the feasibility study yielded positive results and confirmed the platform’s functionality and usability.

CONCLUSIONS

TeleWear represents a unique mHealth approach comprising PRO and mHealth data capturing. With the currently running TeleWear feasibility study, we aim to test and further develop the platform in a real-world setting. A randomized controlled trial including patients with atrial fibrillation that investigates PRO- and ECG-based clinical management based on the established TeleWear infrastructure will evaluate its clinical benefits. Widening the spectrum of health data collection and interpretation beyond the ECG and use of the TeleWear infrastructure in different patient subcohorts with focus on cardiovascular diseases are further milestones of the project with the ultimate goal to establish a comprehensive telemedical center entrenched by mHealth.
Moodbuster (E-MODEL): The feasibility of digital cognitive behavioural therapy (CBT) for depressed older adults: Study protocol of two pilot feasibility studies (Preprint)
Authors: Amarti Khadicha , Schulte Mieke, H., J., , Kleiboer Annet, M., , van Genugten Claire, R., , Oudega Mardien , Sonnenberg Caroline , Gonçalves Gonçalo, C., , Rocha Artur , Riper Heleen
Published: July 2022

BACKGROUND

Internet-based interventions can be effective in the treatment of depression. However, internet-based interventions for older adults with depression are scarce and little is known about their feasibility and effectiveness.

OBJECTIVE

To present the design of two studies aiming to assess the feasibility of internet-based cognitive behavioural treatment (CBT) for older adults with depression (E-MODEL). We will assess the feasibility of an online, guided version of E-MODEL among depressed older adults from the general population as well as the feasibility of a blended format (combining integrated face-to-face sessions and internet-based modules) in specialised mental health care outpatient clinic.

METHODS

A single-group pretest-posttest design will be applied for both settings. The primary outcome of the studies will be feasibility in terms of (a) acceptance and satisfaction (measured with the Client Satisfaction Questionnaire-8, (b) usability (measured with the System Usability Scale) and (c) engagement (measured with the Twente Engagement with Ehealth Technologies Scale). Secondary outcomes include: (a) severity of depressive symptoms (PHQ-8), (b) participant and therapist experience with the digital technology (with the use of qualitative interviews), (c) working alliance between patient and practitioner (from both perspectives; WAI-SF), (d) technical alliance between patient and the platform (WAI-TECH-SF) and (e) uptake in terms of attemped and completed modules. N=30 older adults with mild to moderate depressive symptoms (score between 5 and 11 as measured with the Geriatric Depression Scale 15) will be recruited from the general population. N=15 older adults with moderate to severe depressive symptoms (GDS-15 score between 8 and 15) will be recruited from a specialised mental health care outpatient clinic.

RESULTS

A mixed-method approach of quantitative and qualitative analyses will be adopted. Both the primary and secondary outcomes will be additionally explored with an individual semistructured interview and synthesized descriptively. Descriptive statistics (Mean and SDs) will be used to examine the primary and secondary outcome measures. Within-group depression severity will be analyzed using a two-tailed paired sample t-test to investigate differences between time points. The interviews will be recorded and analyzed using thematic analysis.

CONCLUSIONS

The results of this pilot study will show whether this platform is feasible among the older adult population in a blended and guided format in the two settings as well as a first exploration of the size of the effect of E-MODEL in terms of decrease of depressive symptoms.
Automated Prediction of Kidney Failure in IgA Nephropathy with Deep Learning from Biopsy Images
Authors: Testa Francesca , Fontana Francesco , Pollastri Federico , Chester Johanna , Leonelli Marco , Giaroni Francesco , Gualtieri Fabio , Bolelli Federico , Mancini Elena , Nordio Maurizio , Sacco Paolo , Ligabue Giulia , Giovanella Silvia , Ferri Maria , Alfano Gaetano , Gesualdo Loreto , Cimino Simonetta , Donati Gabriele , Grana Costantino , Magistroni Riccardo
Published: July 2022

Background and objectives

Digital pathology and artificial intelligence offer new opportunities for automatic histologic scoring. We applied a deep learning approach to IgA nephropathy biopsy images to develop an automatic histologic prognostic score, assessed against ground truth (kidney failure) among patients with IgA nephropathy who were treated over 39 years. We assessed noninferiority in comparison with the histologic component of currently validated predictive tools. We correlated additional histologic features with our deep learning predictive score to identify potential additional predictive features.

Design, setting, participants, & measurements

Training for deep learning was performed with randomly selected, digitalized, cortical Periodic acid–Schiff–stained sections images (363 kidney biopsy specimens) to develop our deep learning predictive score. We estimated noninferiority using the area under the receiver operating characteristic curve (AUC) in a randomly selected group (95 biopsy specimens) against the gold standard Oxford classification (MEST-C) scores used by the International IgA Nephropathy Prediction Tool and the clinical decision supporting system for estimating the risk of kidney failure in IgA nephropathy. We assessed additional potential predictive histologic features against a subset (20 kidney biopsy specimens) with the strongest and weakest deep learning predictive scores.

Results

We enrolled 442 patients; the 10-year kidney survival was 78%, and the study median follow-up was 6.7 years. Manual MEST-C showed no prognostic relationship for the endocapillary parameter only. The deep learning predictive score was not inferior to MEST-C applied using the International IgA Nephropathy Prediction Tool and the clinical decision supporting system (AUC of 0.84 versus 0.77 and 0.74, respectively) and confirmed a good correlation with the tubolointerstitial score (r=0.41, P<0.01). We observed no correlations between the deep learning prognostic score and the mesangial, endocapillary, segmental sclerosis, and crescent parameters. Additional potential predictive histopathologic features incorporated by the deep learning predictive score included (1) inflammation within areas of interstitial fibrosis and tubular atrophy and (2) hyaline casts.

Conclusions

The deep learning approach was noninferior to manual histopathologic reporting and considered prognostic features not currently included in MEST-C assessment.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_07_26_CJN01760222.mp3.
Acute Kidney Injury in Patients with Liver Disease
Authors: Cullaro Giuseppe , Kanduri Swetha Rani , Velez Juan Carlos Q.
Published: July 2022

AKI is commonly encountered in patients with decompensated cirrhosis, and it is associated with unfavorable outcomes. Among factors specific to cirrhosis, hepatorenal syndrome type 1, also referred to as hepatorenal syndrome-AKI, is the most salient and unique etiology. Patients with cirrhosis are vulnerable to traditional causes of AKI, such as prerenal azotemia, acute tubular injury, and acute interstitial nephritis. In addition, other less common etiologies of AKI specifically related to chronic liver disease should be considered, including abdominal compartment syndrome, cardiorenal processes linked to cirrhotic cardiomyopathy and portopulmonary hypertension, and cholemic nephropathy. Furthermore, certain types of GN can cause AKI in cirrhosis, such as IgA nephropathy or viral hepatitis related. Therefore, a comprehensive diagnostic approach is needed to evaluate patients with cirrhosis presenting with AKI. Management should be tailored to the specific underlying etiology. Albumin-based volume resuscitation is recommended in prerenal AKI. Acute tubular injury and acute interstitial nephritis are managed with supportive care, withdrawal of the offending agent, and, potentially, corticosteroids in acute interstitial nephritis. Short of liver transplantation, vasoconstrictor therapy is the primary treatment for hepatorenal syndrome type 1. Timing of initiation of vasoconstrictors, the rise in mean arterial pressure, and the degree of cholestasis are among the factors that determine vasoconstrictor responsiveness. Large-volume paracentesis and diuretics are indicated to relieve intra-abdominal hypertension and renal vein congestion. Direct-acting antivirals with or without immunosuppression are used to treat hepatitis B/C–associated GN. In summary, AKI in cirrhosis requires careful consideration of multiple potentially pathogenic factors and the implementation of targeted therapeutic interventions.
Manual de Seguridad en Laboratorio de Microbiología Molecular
Authors:   Facultad de Medicina Veterinaria y Zootecnia, Lazo García Elvía , Valdés Velázquez Liliana Manuela ,   Facultad de Medicina Veterinaria y Zootecnia
Published: July 2022

Esta obra trata los lineamientos enfocados a la reducción y control de riesgos biológicos, químicos o físicos, procurando mantener áreas de trabajo seguras. La Facultad de Medicina Veterinaria y Zootecnia cuenta con distintos laboratorios y de allí su interés en procurar mantener condiciones seguras, en particular en el Laboratorio de Microbiología molecular, analizando la aplicación de medidas de seguridad y de bioseguridad, para lograr un manejo adecuado de residuos peligrosos y de residuos peligrosos biológicos infecciosos. De interés para el profesionista, encontrará en este texto: hábitos de trabajo, reglas de seguridad, equipo de protección personal, clave de colores y formas de seguridad, equipos de laboratorio y protocolos aplicados en múltiples procedimientos.
CFD Simulation of Tapered Coil by Using Silicon Dioxide and Zinc Oxide Nanofluid with Water and Ethylene Glycol as Its Base Fluid
Authors: Kumar Vishal , Pandey Vijaykant
Published: July 2022

Abstract: Helical coils are very essential for various heat exchangers, nuclear reactors and in chemical engineering because of large quantity of heat transfer in a small space with high heat transfer rates and slight residence time dispersals even it suffers through a disadvantage of larger pressure drop. The curvature creates secondary flow arrangement which is perpendicular to main axial stream path. The secondary flow has insignificant capability to improve heat transfer owed to mingling of the fluid. The objective of this work is to compare and increase the pressure drop inside tapered helical coil heat exchanger in copper tube to succeed a better and more quantitative insight into heat transfer process by increasing secondary flow inside the coil and this can allow proper intermixing of the fluid and to maintain desired flow rate inside the helical coil. I work on CFD to analyze the helical coil by using ANSYS 15. Generation of 3D CAD model of aluminium and copper tapered helical tube of diameter (d) 10 mm keeping PCD 50 mm, pitch 20 mm , tapered angle 20 and length of 500 mm by using SOLIDWORKS and exporting to the IGES format and then import in ANSYS fluent 15
Tanggung Jawab Rumah Sakit terhadap Pemenuhan Hak Pasien pada Masa Pandemi COVID-19
Authors: Kartikawati Dwi Ratna
Published: July 2022

Hospitals are one of the facilities that support efforts in handling Covid-19. Hospitals provide the basis for medical services. The implementer of medical services has many actors in it, so the hospital as part of the facility needs to be legally clarified. Indonesia has issued regulations contained in Law Number 44 of 2009 concerning Hospitals. This study aims to see how the provisions of the legislation in Indonesia accommodate the position of hospitals in handling Covid-19. The analytical method used is qualitative analysis that uses a literature study approach in seeing the development of the number of legal sources. With this method, a number of specific descriptions are obtained that can provide information on how the duties, functions, obligations, and quality standards are supported by legislation for hospitals to be able to optimize medical services. The results of this study indicate that during the Covid-19 pandemic, hospitals have a great responsibility in improving services for patients infected with Covid-19. Various laws and regulations have explained how the central position of hospitals that need to improve medical services during the Covid-19 pandemic is still happening. Good medical services and in accordance with the rules will be a good foundation for handling the Covid-19 pandemic.
Keywords: Hospital; Medical Services; Law: Covid-19
Abstrak
Rumah sakit menjadi salah satu dari fasilitas yang mendukung upaya dalam penanganan Covid-19. Rumah sakit memberikan dasar untuk pelayanan medis. Pelaksana dari pelayanan medis memiliki banyak aktor didalamnya, sehingga rumah sakit sebagai bagian dari fasilitas perlu diperjelas kedudukan secara hukum. Indonesia telah mengeluarkan peraturan yang tertuang dalam  Undang-Undang Nomor 44 Tahun 2009 Tentang Rumah Sakit. Penelitian ini bertujuan untuk melihat bagaimana kapasitas peraturan perundang-undangan di Indonesia mengakomodir posisi rumah sakit pada penanganan Covid-19. Metode analisis yang digunakan adalah analisis kualitatif yang menggunakan pendekatan studi pustaka dalam melihat perkembangan sejumlah sumber hukum. Dengan metode ini maka didapatkan sejumlah deskripsi khusus yang dapat memberikan informasi mengenai bagaimana tugas, fungsi, hak, kewajiban dan standar mutu yang didukung peraturan perundang-undangan bagi rumah sakit untuk mampu mengoptimalkan pelayanan medis. Hasil penelitian ini menunjukan bahwa pada masa pandemic Covid-19 rumah sakit memiliki tanggung jawab yang besar dalam meningkatkan pelayanan untuk pasien yang terinfeksi Covid-19. Dalam berbagai peraturan perundang-undangan telah dijelaskan bagaimana posisi sentral rumah sakit yang perlu untuk meningkatkan pelayanan medis selama pandemi Covid-19 masih terjadi. Pelayanan medis yang baik dan sesuai dengan aturan akan menjadi landasan baik bagi penanganan pandemi Covid-19.
A Pilot Study on the Use of App Tools in Synchronous Video Korean Lectures
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Minyoung
Published: July 2022

Objectives The purpose of this study is to design a teaching method in which a Korean grammar app is applied to “Synchronous Classroom Access Type” video lectures. Synchronous video classes are generally used, but there are many problems as we know. So I chose a method of Blended Learning as a complement to it. However, since the experiment has to be done on a large scale, a pilot study was first conducted in this study.
Methods This paper designed a teaching method that applied “Sejong Korean Grammar APP” while taking Skype Business platform classes. For this, First I analyzed the classroom environment. Second I made a hypothesis after exploring theories. Third the experiment was designed and conducted. The control group submit the Handout task, and the experimental group played the APP game. All students took midterm and final exams and were interviewed.
Results The purposes of this study were to specify variables related to convergence competency, and to analyze the structural relationships among them. The purposes of this study were to specify variables related to convergence competency, and to analyze the structural relationships among them.
Conclusions As a result, the experimental group achieved good results. There were also positive responses from individual interviews. This pilot study suggests that video education and app-using classes can be harmonized. However, this study needs to be modified in many parts because the sample of the experimental group is small.
Analysis of the Effect of Teaching Presence and Learning Presence on Learning Outcomes in Online Classes of 『Presentation and Discussion』
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yu Soyeon , Kim Eunkyung , Ku Seonu
Published: July 2022

Objectives The purpose of this study is to examine the learners' perception of teaching presence and learning presence, relationship between presence and learning outcomes in online classes of 『Presentation and Discussion』 centered on communication competency.
Methods To this end, a survey was conducted on 146 students of K University's 『Presentation and Discussion』 located in Chungcheongnam-do to measure the sense of teaching presence, learning presence, and learning outcomes. The survey tool is consist of 60 questions, and the collected response results were statistically analyzed using the IBM SPSS Statistics 22 program after coding work.
Results Among the characteristics of learners, there was a difference in learning outcomes according to their major, and the learning outcomes of engineering learners was relatively high. In addition, There was a high correlation between teaching presence and cognitive presence, Learning satisfactory and cognitive presence, willingness to continue learning and social presence in the relation of presence and learning outcomes. As a result of conducting multiple regression analysis to predict learning outcomes in online classes, learning satisfaction affects in order of cognitive presence, emotional presence, social presence, and teaching presence. These presences are related to about 70 percent, while it was found that only a sense of social reality explained the intention to continue learning by about 16%. In other words, it was confirmed that learning satisfaction had higher correlation with teaching presence or learning presence contrasted to willingness to continue learning.
Conclusions This study can be used in the design of classes that can enhance the teaching and learning presence and learning outcomes recognized by learners in online classes of speaking and listening subjects that value communication skills.
Mediated Effect of Self-efficacy and Peers, Director’s Trust on Terms with Early Childhood Teacher’s Job Identity and Organizational Commitment
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, GO JEONGLEE
Published: July 2022

Objectives The purpose of this study was to investigate mediated effect of self-efficacy and peers, director’s trust on terms with early childhood teacher’s job identity and organizational commitment.
Methods To achieve this purpose, the study subject were university student’s university life adaptation variable centering around positive psychological capital, social support, career decision self-efficacy. To achieve this purpose, the study subject were private establishment kindergarten 249 teachers in gyeong sang nam do and question investigation was performed aimed at this students during 2 weeks. To measure early childhood teacher’s job identity, self-efficacy and peers, director’s trust, organizational commitment, measurement tool was made existing tool. On this basis, question material was collected and collected question material was analyzed using SPSS 23 program.
Results Result of this study are summarized as follows: First, early childhood teacher’s job identity, self-efficacy and peers, director’s trust had an effect on organizational commitment positively. Second, self-efficacy and peers, director’s trust had mediated effect partly on terms with early childhood teacher’s job identity and organizational commitment.
Conclusions This study had meaning to analyze relevant variable’s relative influence. for early childhood teacher’s organizational commitment. On this study result, plan to reinforce early childhood teacher’s job identity, self-efficacy and peers, director’s trust had to devise for childhood teacher’s organizational commitment.
The Development of a Career Counseling Program for Protean Careers for University Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Choi Jieun , Cho Youngsun
Published: July 2022

Objectives In this study designed a protean career-oriented career counseling program for university students and verified the effect of this program on the protean career cognition, protean career orientation, protean career behavior.
Methods To this end, a protean career-oriented career counseling program was devised as an analysis, design, development, implement, and evaluation stage based on the ADDIE model. and the main program was provided to the experimental group of 13 university students, while an ordinary career counseling program was used for the comparison group of 13 students and nothing for the control group of 13 students.
Results First, the final program was developed by establishing the purpose and goal of the program, activity goals and contents for each session, and teaching and learning strategies, and then going through expert validation. Second, as a result of the quantitative analysis, the overall protean career, and the average values of each sub-factor in the experimental group increased after participating in the program, compared to the other groups. Third, as a result of the qualitative analysis, the experimental group was able to develop identity, adaptability, self-directed, value-driven and coping with change, reflective behavior through this program.
Conclusions Based on the results, the program developed in this study is different from existing career counseling programs as it was made suitable for current university students by considering the difference between the traditional and new concepts of career based on the protean career theory. In particular, this program has significance in that it laid the foundation for university students to systematically prepare for their careers while proactively creating their own portfolio from their early years of university.
Mediating Effect of Adaptive Cognitive Emotion Regulation Strategy in the Relationship Between Soldier's Perceived Parents' Negative parenting Attitudes and Social Anxiety
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Bark Kyounghee , Jo Han Ik
Published: July 2022

Objectives The purpose of this study was to examine whether adaptive cognitive emotion regulation strategies mediate the relationship between solder's perceived negative parenting attitudes and social anxiety.
Methods For the purpose of this research, the self-reported questionnaire was gathered from 231 male soldiers serving in K province. The questionnaire included perceived parents' negative attitude scale, adaptive cognitive emotion regulation strategy scale, and social anxiety scale. For data analysis, descriptive statistics and correlation analysis between major variables were performed through SPSS. The mediating effect analysis was performed using SPSS Process Macro, and mediating effect significance was confirmed through bootstrapping function of SPSS Process Macro.
Results First, it appeared that soldiers perceived negative parents' parenting has a positive effect on the social anxiety, and adaptive cognitive emotion regulation strategy has a negative effect on the social anxiety, and the perceived parents' negative parenting has a negative effect on the adaptive cognitive emotion regulation strategy. Second, the mediating effect of adaptive cognitive emotion regulation strategy was significant in the relationship between perceived parents' negative parenting and social anxiety.
Conclusions It suggests that it is necessary to establish counseling and educational intervention strategies to promote the use of adaptive cognitive emotion regulation strategies in order to reduce the social anxiety level of soldiers.
A Study on the Actual and Future of Coding Education for Korean Preschooler: Based on LEGO Play
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lim Hyunju
Published: July 2022

Objectives The purposes of this study, by grasping the current status of early childhood coding education, which is emerging as a global issue, we sought the direction in which early childhood education in Korea should move forward and suggested a new direction for talent education in preparation for the future society.
Methods To this end, the current status of early childhood coding education and domestic early childhood coding education from the perspective of constructivism was identified, the role of Lego play was considered, and the direction of future early childhood education was investigated.
Results To this end, previous studies have shown that domestic infant coding education is not an active subject for infants, and infant coding teaching tools are mainly focused on creative thinking, and teacher competence is important to induce infant interest.
Conclusions The purpose of this study that Lego Play as a learner-centered play tool has the digital literacy skills required in the era of the 4th Industrial Revolution, and at the same time, it has a very important function as a convergence infant coding education that develops creative problem-solving skills through team interaction and cooperation.
An Empirical Study on Improving Pre-service Teachers' Mathematical Knowledge for Teaching (MKT) Level: Based on Advanced Mathematics in China
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Guo Haiyan , Kou Heung
Published: July 2022

Objectives Based on the MKT theory, this study carried out special teaching design and did a teaching experiment, hope to explore the feasibility to improve pre-service teachers' MKT level in mathematics course.
Methods This study adopts the quasi experimental research method, selects Advanced Mathematics as the experimental course, selects the math major students of two parallel classes in the first year of a normal university in China as the research object. Use the 5-factor MKT framework and various effective teaching methods to formulate a special teaching scheme. In the experimental class, the specially designed teaching scheme is used in teaching, while the control class is taught in the conventional way. The scores of self-made MKT questionnaire and concept map are used to compare the MKT level of the two classes before and after the experiment.
Results Before the experiment, the MKT level of the two parallel classes was very low, and there was no difference between the two classes. After a semester of experiment, there was a significant difference between the MKT test scores of the experimental class (M=48.12, SD=7.26) and the control class (M=32.42, SD=6.85) (t=11.12, df=98.00, p=.000).
Conclusions MKT level of pre-service teachers can be improved through Advanced Mathematics. The method of integrating subject matter knowledge (SMK) and pedagogy content knowledge (PCK) under the guidance of MKT can effectively improve the MKT level of pre-service teachers, and their professional level of mathematics can be improved accordingly. MKT 5 factor instructional design teaching plan is a feasible and effective ways to improve MKT level.
Synergistic regulation between leaf N and P on Vcmax and Jmax of species in subtropical karst and non-karst forests of China
Authors: Ni Longkang , Gu Daxing , Qin Jiashuang , He Wen , Huang Kechao , Otieno Dennis
Published: July 2022

Gas exchange capacity of leaves is mainly restricted by the content of N
and P and environmental factors. However, the effects of interaction
between N and P and environmental factors on photosynthetic capacity in
subtropical tree species remain unclear. We measured the gas exchange
parameters (25℃ maximum carboxylation rate [Vcmax,25], and 25℃
maximum electron transport rates [Jmax,25]) and the chemical
properties of leaves (leaf N, leaf P and N:P) in 9 local dominant
species in the subtropical non-karst and karst regions of southwest
China. Environmental factors (temperature [Temp] and soil moisture
content [SMC]) of the study site were also monitored at the same
time. We found that P restriction is common in different research sites.
The results of the mixed linear model show that with the increase of
leaf N content of karst species, the sensitivity of Vcmax,25 to leaf P
increased significantly, and there was a significant interaction of N×P
(P < 0.001). Non-karst species tend to N×SMC interaction (P =
0.04). The difference in N×P interaction on gas exchange parameters
between non-karst and karst species might result from the decoupling
phenomenon of N and P caused by climate change. Factors such as N
sedimentation and soil P loss aggravate the N:P imbalance and lead to
the decoupling effect between N and P elements, and continuously weaken
the influence of N×P interaction on plant Vcmax and Jmax.