bluuebunny/crossref_metadata_2025 huggingface dataset:
Metal Hydride Composite Structures for Improved Heat Transfer and Stability for Hydrogen Storage and Compression Applications
Authors: Liu Liang , Ilyushechkin Alexander , Liang Daniel , Cousins Ashleigh , Tian Wendy , Chen Cherry , Yin Jon , Schoeman Liezl
Published: April 2023

Metal alloys and intermetallic compounds offer an attractive method for safely storing hydrogen (H2). The metal alloys absorb H2 into their structure, often swelling and fracturing as a result of phase transformation during hydride formation/decomposition cycles. The absorption of H2 is an exothermic process, requiring the effective and efficient removal of heat. This can be challenging as heat transfer to/from powdered beds is notoriously difficult, and often limited by poor thermal conductivity. Hence, the observed reaction kinetics for absorption and desorption of H2 is dominated by heat flow. The most common method for improving the thermal conductivity of the alloy powders is to prepare them into composite structures with other high thermal conductivity materials, such as carbons and expanded natural graphite. Such composite structures, some also combined with polymers/resins, can also mitigate safety issues related to swelling and improve cyclic durability. This paper reviews the methods that have been used to prepare such composite structures and evaluates the observed impact on thermal conductivity.
Silicon Anode: A Perspective on Fast Charging Lithium-Ion Battery
Authors: Lee Jun , Oh Gwangeon , Jung Ho-Young , Hwang Jang-Yeon
Published: April 2023

Power sources supported by lithium-ion battery (LIB) technology has been considered to be the most suitable for public and military use. Battery quality is always a critical issue since electric engines and portable devices use power-consuming algorithms for security. For the practical use of LIBs in public applications, low heat generation, and fast charging are essential requirements, but those features are still unsatisfactory so far. In particular, the slow Li+ intercalation kinetics, lithium plating, and self-heat generation of conventional graphite-anode LIBs under fast-charging conditions are impediments to the use of these batteries by the public demands. The use of silicon-based anodes, which are associated with fast reaction kinetics and rapid Li+ diffusion, has great potential to render LIBs suitable for public use in the near future. In this perspective, the challenges in and future directions for developing silicon-based anode materials for realizing LIBs with fast-charging capability are highlighted.
Hybrid Nanostructured Materials as Electrodes in Energy Storage Devices
Authors: Islam Md. Shahinul , Mubarak Mahfuza , Lee Ha-Jin
Published: April 2023

The global demand for energy is constantly rising, and thus far, remarkable efforts have been put into developing high-performance energy storage devices using nanoscale designs and hybrid approaches. Hybrid nanostructured materials composed of transition metal oxides/hydroxides, metal chalcogenides, metal carbides, metal–organic frameworks, carbonaceous compounds and polymer-based porous materials have been used as electrodes for designing energy storage systems such as batteries, supercapacitors (SCs), and so on. Different kinds of hybrid materials have been shown to be ideal electrode materials for the development of efficient energy storage devices, due to their porous structures, high surface area, high electrical conductivity, charge accommodation capacity, and tunable electronic structures. These hybrid materials can be synthesized following various synthetic strategies, including intercalative hybridization, core–shell architecture, surface anchoring, and defect control, among others. In this study, we discuss applications of the various advanced hybrid nanostructured materials to design efficient batteries and SC-based energy storage systems. Moreover, we focus on their features, limitations, and real-time resolutions.
Semi-Quantification of Myocardial Uptake of Bone-Seeking Agents in Suspected Cardiac Amyloidosis
Authors: Campi Cristina , Briani Chiara , Salvalaggio Alessandro , Giraudo Chiara , Cipriani Alberto , Zorzi Alessandro , Zucchetta Pietro , Vettor Roberto , Cecchin Diego
Published: April 2023

Introduction: Bone scintigraphy has emerged as a key tool for non-invasive etiologic diagnosis of transthyretin (ATTR) cardiac amyloidosis (CA). We focused on a new semi-quantification method (on planar imaging) that could complement the qualitative/visual Perugini scoring system, especially when SPET/CT is not available. Material and Methods: We retrospectively/qualitatively evaluated 8674 consecutive, planar 99mTc-biphosphonate scintigraphies (performed for non-cardiac reasons), identifying 68 (0.78%) individuals (mean age 79 ± 7 years, range 62–100 years; female/male ratio 16/52) presenting myocardial uptake. Due to the retrospective nature of the study, no SPET/CT, pathologic or genetic confirmation was obtained. The Perugini scoring system was determined (in patients presenting cardiac uptake) and compared with three newly proposed semi-quantitative indices. We took 349 consecutive bone scintigraphies, qualitatively absent of any cardiac/pulmonary uptake, as “healthy controls” (HC). Results: The heart-to-thigh ratio (RHT) and lung-to-thigh ratio (RLT) indices were significantly higher in patients than in HCs (p ≤ 0.0001). There were statistically significant differences for RHT in HCs vs. patients with qualitative Perugini scores of 1 or >1 (with p ranging from ≤0.001 to ≤0.0001). ROC curves showed that RHT outperformed the other indices and was more accurate in both male and female groups. Furthermore, in the male population, RHT accurately distinguished HCs and patients with scores of 1 (less likely affected by ATTR) from patients with qualitative scores >1 (more likely affected by ATTR) with an AUC of 99% (sensitivity: 95%; specificity: 97%). Conclusion: The proposed semi-quantitative RHT index can accurately/semi-quantitatively distinguish between HCs and subjects probably affected by CA (Perugini scores from 1 to 3), and could be particularly useful when no SPET/CT data are available (such as in retrospective studies and data mining). Furthermore, RHT can semi-quantitatively predict, with very high accuracy, subjects in the male population more likely to be affected by ATTR. The present study, although using a very large sample, is however retrospective, monocentric, and therefore the generalizability of the results should be proved by an accurate external validation. Advances in Knowledge: The proposed heart-to-thigh ratio (RHT) can distinguish healthy controls and subjects that are probably affected by cardiac amyloidosis in a simple and more reproducible way, as compared to standard qualitative/visual evaluation.
Why Does It Shine?—A Prognostic Analysis about Predisposing Factors for Blood–Brain Barrier Damage after Revascularisation of Cerebral Large-Vessel Occlusion
Authors: Knott Michael , Hock Stefan , Soder Liam , Mühlen Iris , Kremer Svenja , Sprügel Maximilian I. , Sembill Jochen A. , Kuramatsu Joji B. , Schwab Stefan , Engelhorn Tobias , Doerfler Arnd
Published: April 2023

Background: Hyperdense lesions in CT after EVT of LVO are common. These lesions are predictors for haemorrhages and an equivalent of the final infarct. The aim of this study based on FDCT was the evaluation of predisposing factors for these lesions. Methods: Using a local database, 474 patients with mTICI ≥ 2B after EVT were recruited retrospectively. A postinterventional FDCT after recanalisation was analysed regarding such hyperdense lesions. This was correlated with a variety of items (demographics, past medical history, stroke assessment/treatment and short-/long-term follow-up). Results: Significant differences were present in NHISS at admission, regarding time window, ASPECTS in initial NECT, location of the LVO, CT-perfusion (penumbra, mismatch ratio), haemostatic parameters (INR, aPTT), duration of EVT, number of EVT attempts, TICI, affected brain region, volume of demarcation and FDCT-ASPECTS. The ICH-rate, the volume of demarcation in follow-up NECT and the mRS at 90 days differed in association with these hyperdensities. INR, the location of demarcation, the volume of demarcation and the FDCT-ASPECTS could be demonstrated as independent factors for the development of such lesions. Conclusion: Our results support the prognostic value of hyperdense lesions after EVT. We identified the volume of the lesion, the affection of grey matter and the plasmatic coagulation system as independent factors for the development of such lesions.
Left Ventricular Global Longitudinal Strain as a Parameter of Mild Myocardial Dysfunction in Athletes after COVID-19
Authors: Schellenberg Jana , Ahathaller Magdalena , Matits Lynn , Kirsten Johannes , Kersten Johannes , Steinacker Juergen Michael
Published: April 2023

Whether symptoms during COVID-19 contribute to impaired left ventricular (LV) function remains unclear. We determine LV global longitudinal strain (GLS) between athletes with a positive COVID-19 test (PCAt) and healthy control athletes (CON) and relate it to symptoms during COVID-19. GLS is determined in four-, two-, and three-chamber views and assessed offline by a blinded investigator in 88 PCAt (35% women) (training at least three times per week/>20 MET) and 52 CONs from the national or state squad (38% women) at a median of two months after COVID-19. The results show that the GLS is significantly lower (GLS −18.53 ± 1.94% vs. −19.94 ± 1.42%, p < 0.001) and diastolic function significantly reduces (E/A 1.54 ± 0.52 vs. 1.66 ± 0.43, p = 0.020; E/E’l 5.74 ± 1.74 vs. 5.22 ± 1.36, p = 0.024) in PCAt. There is no association between GLS and symptoms like resting or exertional dyspnea, palpitations, chest pain or increased resting heart rate. However, there is a trend toward a lower GLS in PCAt with subjectively perceived performance limitation (p = 0.054). A significantly lower GLS and diastolic function in PCAt compared with healthy peers may indicate mild myocardial dysfunction after COVID-19. However, the changes are within the normal range, so that clinical relevance is questionable. Further studies on the effect of lower GLS on performance parameters are necessary.
Fibro-Stenosing Crohn’s Disease: What Is New and What Is Next?
Authors: Solitano Virginia , Dal Buono Arianna , Gabbiadini Roberto , Wozny Marek , Repici Alessandro , Spinelli Antonino , Vetrano Stefania , Armuzzi Alessandro
Published: April 2023

Fibro-stenosing Crohn’s disease (CD) is a common disease presentation that leads to impaired quality of life and often requires endoscopic treatments or surgery. From a pathobiology perspective, the conventional view that intestinal fibro-stenosis is an irreversible condition has been disproved. Currently, there are no existing imaging techniques that can accurately quantify the amount of fibrosis within a stricture, and managing patients is challenging, requiring a multidisciplinary team. Novel therapies targeting different molecular components of the fibrotic pathways are increasing regarding other diseases outside the gut. However, a large gap between clinical need and the lack of anti-fibrotic agents in CD remains. This paper reviews the current state of pathobiology behind fibro-stenosing CD, provides an updated diagnostic and therapeutic approach, and finally, focuses on clinical trial endpoints and possible targets of anti-fibrotic therapies.
Value of Diagnostic Tools in the Diagnosis of Osteomyelitis: Pilot Study to Establish an Osteomyelitis Score
Authors: Hackenberg Roslind K. , Schmitt-Sánchez Fabio , Endler Christoph , Tischler Verena , Surendar Jayagopi , Welle Kristian , Kabir Koroush , Schildberg Frank A.
Published: April 2023

Osteomyelitis (OM) remains one of the most feared complications in bone surgery and trauma. Its diagnosis remains a major challenge due to lack of guidelines. The aim of this study was to prospectively analyze the value of the most common and available diagnostic tools and to establish an OM score to derive treatment recommendations. All patients with suspected OM were included in a prospective pilot study. All patients underwent blood sampling for C-reactive protein and white blood cell count analysis. Magnetic resonance imaging (MRI), and microbiologic and histopathologic samples, were taken from representative sites of initial debridement. All patients were treated according to their OM test results and followed for at least one year. Subsequently, the value of individual or combined diagnostic tools was analyzed in patients with confirmed OM and in patients in whom OM was ruled out. Based on these findings, an OM score was developed that included MRI, microbiology, and histopathology. The score identified all control patients and all but one OM patient, resulting in a correct diagnosis of 93.3%, which was validated in a second independent larger cohort. This was the first study to analyze the value of the most commonly used tools to diagnose OM. The proposed OM score provides a simple scoring system to safely interpret test results with high accuracy.
A Systematic Review of Non-Opioid Pain Management in Chiari Malformation (Type 1) Patients: Current Evidence and Novel Therapeutic Opportunities
Authors: Barpujari Awinita , Kiley Alina , Ross Jennifer A. , Veznedaroglu Erol
Published: April 2023

Chiari Malformation Type I (CM) includes a range of cranial abnormalities at the junction of the skull with the spine, with common symptoms including pain and headaches. Currently, CM pain is managed medically through anti-inflammatory drugs, muscle relaxants, and opioids, while surgical management includes posterior fossa decompression. Given the adverse effects of opioid use, and an ongoing opioid epidemic, there is a need for safe, non-opioid alternatives for clinical pain management. This systematic review was performed to provide an update on the current literature pertaining to the treatment of CM pain with non-opioid alternatives. A literature search was performed in June 2022 utilizing the PubMed and Google Scholar databases, and articles were identified that included information regarding non-opioid pain management in CM patients. A total of 90 articles were obtained from this search, including 10 relevant, drug-specific studies. Two independent reviewers selected and included all relevant articles based on the chosen search criteria to minimize bias risk. Currently available treatments for neurosurgical pain management include anticonvulsants, corticosteroids, NSAIDs, anti-inflammatory drugs, NMDA receptor antagonists, local anesthetics, nerve blocks, scalp blocks, and neuromuscular blocks. While more information is needed on the use of non-opioid pain management, the present literature provides potential evidence of its efficacy amongst the CM patient population, on account of the success that non-opioid pain management has demonstrated within other neurological pain syndromes. Further research into non-pharmacological pain management would also benefit the CM population and could be generalized to related conditions.
Factors Associated with Visual Acuity in Advanced Glaucoma
Authors: Kim Hyun Jee , Sung Mi Sun , Park Sang Woo
Published: April 2023

This study aimed to comprehensively analyze various parameters in advanced glaucoma patients to identify the factors that can affect best-corrected visual acuity (BCVA) in advanced glaucoma. This cross-sectional retrospective study included 113 patients (mean age, 61.66 ± 13.26 years; males, 67) who had advanced glaucomatous damage (113 eyes; mean BCVA, 0.18 ± 0.38 logMAR; mean deviation of 30-2 visual field [VF], −19.08 ± 6.23 dB). Peripapillary retinal nerve fiber layer (RNFL) and total and segmented macular thickness (RNFL, ganglion cell layer (GCL), and inner plexiform layer (GCL)) were measured using Spectralis optical coherence tomography (OCT). Correlations between BCVA and OCT parameters or 30-2 VF parameters were assessed using Pearson correlation analysis. Multivariate regression analysis was performed to determine the factors associated with BCVA in advanced glaucoma patients. Peripapillary RNFL thickness, subfoveal choroidal thickness, and global macular RNFL, GCL, IPL, and total thickness were found to be significantly correlated with BCVA and central visual function. Multivariate analysis showed a significant correlation between subfoveal choroidal thickness and BCVA. In addition, central VF mean sensitivity, especially inferior hemifield, showed a significant relationship with BCVA. In conclusion, subfoveal choroidal thickness and central VF sensitivity, especially the inferior hemifield area, are factors that affect BCVA in advanced glaucoma.
Olfactory Obsessions: A Study of Prevalence and Phenomenology in the Course of Obsessive-Compulsive Disorder
Authors: Żerdziński Maciej , Burdzik Marcin , Żmuda Roksana , Dębski Paweł , Witkowska-Berek Agnieszka , Pląder Anita , Mozdrzanowska Patrycja , Stawowy Marta , Sztuk Joanna , Poremba Karolina , Piegza Magdalena , Gorczyca Piotr
Published: April 2023

Olfactory obsessions (OOs) are rarely described in the medical literature. The features of OOs appear consistent with characteristics of a typical obsession, but since they do not involve the realm of thought, it is questionable to term them obsessions per se. Olfactory Reference Syndrome (ORS) presents OOs inconsistently and is a distinctive diagnostic category related to OCD. Therefore, the primary objectives of our study were not only to assess the prevalence of OOs in OCD patients, but also to demonstrate their phenomenological consistency with other OCD symptoms. The study group consisted of 75 patients already diagnosed and treated for OCD. Hence, a comparison was made between OCD patients with and without OOs in terms of: symptom severity, level of insight and comorbidities. Olfactory obsessions (OOs) were found in 21.33% (n = 16). OOs induced compulsive behavior in more than 93% of subjects. The presence of OOs did not significantly differentiate the studied groups in terms of OCD severity (p = 0.876), level of insight (p = 0.680), depression (p = 0.746), mania (p = 0.525) and OCDP traits (p = 0.624). However, a comparison of the two groups showed that OOs patients presented higher levels of hostility (p = 0.036), cognitive impulsivity (p = 0.039), magic-type obsession (75% vs. 35.59%), and contamination obsession (87.50% vs. 67.80%). Conclusions: OOs frequently occur in the course of OCD, and their phenomenology is typical of this disorder. OOs are not a symptom of thought content disorders and are sensory in nature, which is not included in the definition of obsession. The presence of OOs in OCD provokes hostility and cognitive impulsivity. It can be assumed that the Olfactory Obsessions Questionnaire accurately identifies olfactory obsessions.
Maternal and Perinatal Outcome in a Contemporary Cohort of Patients with Portal Hypertension: A Single-Center Experience
Authors: Kosian Philipp , Jansen Christian , Chang Johannes , Praktiknjo Michael , Ayub Tiyasha Hosne , Gembruch Ulrich , Merz Waltraut M.
Published: April 2023

Background: Portal hypertension in pregnancy is characterized by an increased perinatal and maternal complication rate. The purpose of this study was to evaluate the perinatal and maternal outcomes of these high-risk pregnancies at our tertiary center. Methods: We identified pregnancies with portal hypertension in our departmental database for the years 2013 to 2021. The medical history and perinatal and maternal data were extracted from medical records. Results: Eleven cases were identified. In pregnancy, delivery and postpartum, complications occurred in 72.7% of cases and included among others ascites, subclavian thrombosis, variceal-ligation-induced ulcer bleeding and postoperative hemorrhage. The cesarean delivery rate was 72.7% (n = 8); five of these were done for obstetric or fetal indications. The rate of preterm birth and admissions to neonatal intensive care unit were high (54.5% and 45.5%, respectively). Conclusions: Our case series substantiates the high maternal and perinatal complication rates seen in portal hypertension. The prevention of thromboembolic and bleeding complications was the main challenge. Care by an interdisciplinary team of experts is crucial for a successful perinatal and maternal outcome.
Do Insomnia Treatments Improve Daytime Function?
Authors: Watson Nathaniel F. , Bertisch Suzanne M. , Morin Charles M. , Pelayo Rafael , Winkelman John W. , Zee Phyllis C. , Krystal Andrew D.
Published: April 2023

A scientific advisory panel of seven U.S. and Canadian sleep experts performed a clinical appraisal by comparing general medical opinion, assessed via a survey of practicing clinicians, regarding insomnia treatment, with the available scientific evidence. This clinical appraisal focuses on the specific statement, “Treatments for insomnia have uniformly been shown to significantly improve the associated daytime impairment seen with insomnia.” The advisory panel reviewed and discussed the available body of evidence within the published medical literature to determine what discrepancies may exist between the currently published evidence base and general medical opinion. The advisory panels’ evaluation of this statement was also compared with the results of a national survey of primary care physicians, psychiatrists, nurse practitioners, physician assistants, and sleep specialists in the United States. Contrary to general medical opinion, the expert advisory panel concluded that the medical literature did not support the statement. This gap highlights the need to educate the general medical community regarding insomnia treatment efficacy in pursuit of improved treatment outcomes.
Effect of Splinting on Orthodontic Mini-Implant Tipping and Bone Histomorphometric Parameters: An In Vivo Animal Model Study
Authors: Fontes Joana , Martin Victor Zacharias , Resende Marta , Colaço Bruno , Gomes Pedro de Sousa , Amarante José Manuel
Published: April 2023

This study aimed to address the stability of orthodontic mini-implants submitted to an immediate orthodontic functional load, in splinted or unsplinted conditions, further characterizing the histomorphometric parameters of the neighboring bone tissue, in an in vivo experimental model. Mini-implants (1.4 × 6.0 mm) were placed in the proximal tibia of New Zealand White rabbits and immediately loaded with a 150 g force. Tissue healing was characterized within 8 weeks. Microtomography was used to assess the mini-implants’ tipping and bone histomorphometric indexes. Loaded implants were evaluated in splinted and unsplinted conditions, with data being compared to that of unloaded mini-implants with the Kruskal–Wallis nonparametric test, followed by Dunn’s multiple comparison tests. The splinting of mini-implants submitted to immediate orthodontic loading significantly reduced the tipping to levels similar to those of unloaded mini-implants. Immediate loading further increased the histomorphometric indexes associated with bone formation at the peri-implant region, in both splinted and unsplinted conditions, with no significant differences between the tension and compression regions. Accordingly, within this experimental setting, splinting was found to lessen tipping and mini-implants’ displacement, without affecting the increased bone formation at the peri-implant region, induced by a functional orthodontic load.
Research on the Influence Path of Metacognitive Reading Strategies on Scientific Literacy
Authors: Xie Yong , Wang Jingying , Li Siqi , Zheng Yonghe
Published: April 2023

This study aims to examine influence paths of three metacognitive reading strategies (metacognitive understanding and remembering strategies, metacognitive summarizing strategies and metacognitive assessing credibility strategies) on scientific literacy, mediated by reading self-efficacy and reading literacy. The dataset included 11,420 15-year-old students from four Chinese provinces (Beijing, Shanghai, Jiangsu and Zhejiang) who took part in the Programme for International Student Assessment (PISA) in 2018. The results of structural equation model showed that metacognitive assessing credibility strategies had the greatest effect on the scientific literacy, and reading literacy played an important mediating role in the relationship between the three metacognitive reading strategies and scientific literacy. The results of the multi-group structural equation model indicated that there were significant differences in influence pathways between boys and girls, and that the reading self-efficacy of boys and girls played a different role in the impact of metacognitive summarizing strategies on scientific literacy. This study reveals the mechanism and gender difference of metacognitive reading strategies on the scientific literacy.
Optical Methods of Error Detection in Additive Manufacturing: A Literature Review
Authors: Wylie Brianna , Moore Carl
Published: April 2023

Additive Manufacturing (AM) has been a growing industry, specifically when trying to mass produce products more cheaply and efficiently. However, there are too many current setbacks for AM to replace traditional production methods. One of the major problems with 3D printing is the high error rate compared to other forms of production. These high error rates lead to wasted material and valuable time. Furthermore, even when parts do not result in total failure, the outcome can often be less than desirable, with minor misprints or porosity causing weaknesses in the product. To help mitigate error and better understand the quality of a given print, the field of AM monitoring in research has been ever-growing. This paper looks through the literature on two AM processes: fused deposition modeling (FDM) and laser bed powder fusion (LBPF) printers, to see the current process monitoring architecture. The review focuses on the optical monitoring of 3D printing and separates the studies by type of camera. This review then summarizes specific trends in literature, points out the current limitations of the field of research, and finally suggests architecture and research focuses that will help forward the process monitoring field.
Area Contrast Distribution Loss for Underwater Image Enhancement
Authors: Zhou Jiajia , Zhuang Junbin , Zheng Yan , Li Juan
Published: April 2023

In this paper, we aim to design a lightweight underwater image enhancement algorithm that can effectively solve the problem of color distortion and low contrast in underwater images. Recently, enhancement methods typically optimize a perceptual loss function, using high-level features extracted from pre-trained networks to train a feed-forward network for image enhancement tasks. This loss function measures the perceptual and semantic differences between images, but it is applied globally across the entire image and does not consider semantic information within the image, which limits the effectiveness of the perceptual loss. Therefore, we propose an area contrast distribution loss (ACDL), which trains a flow model to achieve real-time optimization of the difference between output and reference in training. Additionally, we propose a novel lightweight neural network. Because underwater image acquisition is difficult, our experiments have shown that our model training can use only half the amount of data and half the image size compared to Shallow-UWnet. The RepNet network reduces the parameter size by at least 48% compared to previous algorithms, and the inference time is 5 times faster than before. After incorporating ACDL, SSIM increased by 2.70% and PSNR increased by 9.72%.
Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp.
Authors: Stemler Jannik , Többen Christina , Lass-Flörl Cornelia , Steinmann Jörg , Ackermann Katharina , Rath Peter-Michael , Simon Michaela , Cornely Oliver Andreas , Koehler Philipp
Published: April 2023

With increasing frequency, clinical and laboratory-based mycologists are consulted on invasive fungal diseases caused by rare fungal species. This review aims to give an overview of the management of invasive aspergillosis (IA) caused by non-fumigatus Aspergillus spp.—namely A. flavus, A. terreus, A. niger and A. nidulans—including diagnostic and therapeutic differences and similarities to A. fumigatus. A. flavus is the second most common Aspergillus spp. isolated in patients with IA and the predominant species in subtropical regions. Treatment is complicated by its intrinsic resistance against amphotericin B (AmB) and high minimum inhibitory concentrations (MIC) for voriconazole. A. nidulans has been frequently isolated in patients with long-term immunosuppression, mostly in patients with primary immunodeficiencies such as chronic granulomatous disease. It has been reported to disseminate more often than other Aspergillus spp. Innate resistance against AmB has been suggested but not yet proven, while MICs seem to be elevated. A. niger is more frequently reported in less severe infections such as otomycosis. Triazoles exhibit varying MICs and are therefore not strictly recommended as first-line treatment for IA caused by A. niger, while patient outcome seems to be more favorable when compared to IA due to other Aspergillus species. A. terreus-related infections have been reported increasingly as the cause of acute and chronic aspergillosis. A recent prospective international multicenter surveillance study showed Spain, Austria, and Israel to be the countries with the highest density of A. terreus species complex isolates collected. This species complex seems to cause dissemination more often and is intrinsically resistant to AmB. Non-fumigatus aspergillosis is difficult to manage due to complex patient histories, varying infection sites and potential intrinsic resistances to antifungals. Future investigational efforts should aim at amplifying the knowledge on specific diagnostic measures and their on-site availability, as well as defining optimal treatment strategies and outcomes of non-fumigatus aspergillosis.
Endotypes of Nasal Polyps in Children: A Multidisciplinary Approach
Authors: Sitzia Emanuela , Santarsiero Sara , Marini Giulia , Majo Fabio , De Vincentiis Marcello , Cristalli Giovanni , Artesani Maria Cristina , Fiocchi Alessandro Giovanni
Published: April 2023

Nasal polyps (NPs) are rarely reported in childhood and usually represent red flags for systemic diseases, such as cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and immunodeficiencies. The European Position Paper released in 2020 (EPOS 2020) provided a detailed classification and defined the correct diagnostic and therapeutic approaches. We report a one-year experience of a multidisciplinary team, made up of otorhinolaryngologists, allergists, pediatricians, pneumologists and geneticists, with the aim of ensuring a personalized diagnostic and therapeutic management of the pathology. In 16 months of activity, 53 patients were admitted (25 children with chronic rhinosinusitis with polyposis and 28 with antro-choanal polyp). All patients underwent phenotypic and endo-typic assessment, using proper classification tools for nasal pathology (both endoscopic and radiological), as well as adequate cytological definition. An immuno–allergic evaluation was carried out. Pneumologists evaluated any lower airway respiratory disease. Genetic investigations concluded the diagnostic investigation. Our experience enhanced the complexity of children’s NPs. A multidisciplinary assessment is mandatory for a targeted diagnostic and therapeutic pathway.
Trauma Experiences Are Common in Anorexia Nervosa and Related to Eating Disorder Pathology but Do Not Influence Weight-Gain during the Start of Treatment
Authors: Sjögren Magnus , Lichtenstein Mia Beck , Støving Rene Klinkby
Published: April 2023

Objective: The main characteristics of Anorexia Nervosa (AN) in adults are restriction of energy intake relative to requirements leading to significant weight loss, disturbed body image, and intense fear of becoming fat. Traumatic experiences (TE) have been reported as common, although less is known about the relationship with other symptoms in severe AN. We investigated the presence of TE, PTSD, and the relation between TE, eating disorder (ED) symptoms, and other symptoms in moderate to severe AN (n = 97) at admission to inpatient weight-restoration treatment. All patients were enrolled in the Prospective Longitudinal all-comer inclusion study on Eating Disorders (PROLED). Methods: TE were assessed using the Post-traumatic stress disorder checklist, Civilian version (PCL-C), and ED symptoms using the Eating Disorder Examination Questionnaire (EDE-Q); depressive symptoms were assessed using the Major Depression Inventory (MDI), and the presence of Post-traumatic Stress Disorder (PTSD) was diagnosed according to ICD-10 criteria. Results: The mean score on PCL-C was high (mean 44.6 SD 14.7), with 51% having a PCL-C score at or above 44 (n = 49, suggested cut-off for PTSD), although only one individual was clinically diagnosed with PTSD. There was a positive correlation between baseline scores of PCL-C and EDE-Q-global score (r = 0.43; p < 0.01) as well as of PCL-C and all EDE-Q subscores. None of the included patients were admitted for treatment of TE/PTSD during the first 8 weeks of treatment. Conclusions: In a group of patients with moderate to severe AN, TE were common, and scores were high, although only one had a diagnosis of PTSD. TE were related to ED symptoms at baseline, but this association diminished during the weight restoration treatment.
Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System
Authors: Dettori Cristina , Ronca Francesca , Scalese Marco , Saponaro Federica
Published: April 2023

Parathyroid Hormone (PTH) plays a crucial role in the maintenance of calcium homeostasis directly acting on bone and kidneys and indirectly on the intestine. However, a large family of PTH-related peptides exists that exerts other physiological effects on different tissues and organs, such as the Central Nervous System (CNS). In humans, PTH-related peptides are Parathyroid Hormone (PTH), PTH-like hormones (PTHrP and PTHLH), and tuberoinfundibular peptide of 39 (TIP39 or PTH2). With different affinities, these ligands can bind parathyroid receptor type 1 (PTH1R) and type 2 (PTH2R), which are part of the type II G-protein-coupled-receptors (GPCRs) family. The PTH/PTHrP/PTH1R system has been found to be expressed in many areas of the brain (hippocampus, amygdala, hypothalamus, caudate nucleus, corpus callosum, subthalamic nucleus, thalamus, substantia nigra, cerebellum), and literature data suggest the system exercises a protective action against neuroinflammation and neurodegeneration, with positive effects on memory and hyperalgesia. TIP39 is a small peptide belonging to the PTH-related family with a high affinity for PTH2R in the CNS. The TIP39/PTH2R system has been proposed to mediate many regulatory and functional roles in the brain and to modulate auditory, nociceptive, and sexual maturation functions. This review aims to summarize the knowledge of PTH-related peptides distribution and functions in the CNS and to highlight the gaps that still need to be filled.
Determinants of Financial Literacy: Analysis of the Impact of Family and Socioeconomic Variables on Undergraduate Students in the Slovak Republic
Authors: Böhm Patrik , Böhmová Gabriela , Gazdíková Jana , Šimková Viktória
Published: April 2023

Technological progress and the development of electronic services make financial services one of the fastest-growing sectors. The role of the current education system is to ensure that all users of an ever-increasing variety of products and services understand them and are able to use them efficiently. However, in terms of gender, socioeconomic, and demographic factors, the existing system of financial literacy education exhibits considerable disparity. The main goal of this research was to identify which factors had the greatest impact on the level of financial literacy and to analyse the magnitude of that impact. The study involved 363 first-year undergraduate students at the University of Žilina, Slovakia, and consisted of two parts—a questionnaire and a test that evaluated the impact of five groups of factors on the level of financial literacy. The research results suggest that the student’s gender, father’s education, family’s financial background, and student’s part-time work experience were among the most important determinants of financial literacy. Identifying these factors can aid in the adjustment of financial literacy education to reduce identified inequalities.
The Paradox of the Payday Borrower: A Case Study of the Role of Planned Behavior in Borrowers’ Motivations and Experiences
Authors: Herremans Irene , Hedges Peggy , Mahmoudian Fereshteh , Kleffner Anne , Tahir Mahrukh
Published: April 2023

This research used the theory of planned behavior as a framework to investigate the role of attitudes, behavioral control, norms, and previous behavior in payday loan borrowers’ difficulty or lack of difficulty in repaying loans. The data were collected from 138 respondents with payday loan experience via a questionnaire in a city in a western province in Canada as part of a campaign to change payday loan regulations. The research findings show that different approaches are necessary to address the needs of distinct types of payday borrowers, based on their repayment abilities and whether the loan improved their quality of life in the long term. Furthermore, we found, similar to previous literature, a group of payday borrowers who lack financial confidence. This sub-group is referred to as the “unsure” sub-group in our research and provides opportunities to improve the payday learning context. To accommodate the unsure group, payday lenders and conventional financial institutions can collaborate to offer innovative financial instruments, improve financial literacy through education, and provide better access to information about borrowers’ financial status. The confirmation of this unsure group also leads us to recommend further study to determine opportunities for payday borrowers to become better informed about their options, to increase financial confidence.
Analysis of Trends in Mortgage Lending in the Agricultural Sector of Ukraine
Authors: Perevozova Iryna , Malynka Oksana , Nitsenko Vitalii , Kryshtal Halyna , Kostiuk Viktoriia , Mishchenko Vitaliia
Published: April 2023

This study has the following objectives: to analyze the state of agrarian business lending and the market of banking services, establish the reasons for the insufficient level of mortgage lending implementation, and develop ways and tools to improve lending to the agrarian sector. The research methodology considers a systematic approach to the statistical analysis of bank lending in the agricultural sector of Ukraine, the development of criteria, and the implementation of the hierarchy analysis method for the reasonable selection of a loan product and banking institution. We conducted an analysis of the current state of lending to agricultural enterprises. We also analyzed lending trends, loan products, and basic lending terms by banks of Ukraine to agricultural enterprises. The share of bank lending of the working capital of the agricultural industry was estimated. The dynamics of preferential lending to the agricultural sector were determined. Its essence is that banks with partial repayment of loan rates are given loans at the expense of the state budget. The directions and volumes of borrowed loan resources usage by agricultural enterprises were considered. It is recommended to use the hierarchy analysis method by T. Saaty for choosing an effective loan product. We developed the criteria that could be applied when selecting a loan product. We also determined potential directions for the development of mortgage lending for the agricultural sector.
The Decline and Possible Return of Silvipastoral Agroforestry in Sweden
Authors: Kumm Karl-Ivar , Hessle Anna
Published: April 2023

Silvipastoral agroforestry in the form of forest grazing and wooded semi-natural pastures has historically been very important for the Swedish supply of food and wood products for local use. Since the end of the 1800s, this form of combined production system has greatly decreased and now covers only 1% of Sweden’s land area. However, in recent decades it has gained increased relevance for reasons of landscape, biodiversity and climate. Agroforestry’s decline and possible future increase are described through reviews of statistics and the literature read by farmers and politicians whose decisions are behind the development. Especially when it comes to biodiversity and climate, this review also includes the scientific literature. Surveys on Swedish citizens’ valuation of silvipastoral agroforestry landscapes compared to treeless pasture and closed forest are also reviewed. It is possible that efforts to increase Sweden’s low self-sufficiency in beef and lamb meat, the coming requirements according to the EU’s nature restoration law and the need to limit climate change through carbon sequestration in trees may again increase the area of silvipastoral agroforestry. For this to be economically feasible, large grazing areas can be created out of remaining small scattered wooded semi-natural pastures and intervening forestland, which historically may have been grazed forests.
Does Land Lease Affect the Multidimensional Poverty Alleviation? The Evidence from Jiangxi, China
Authors: Xiao Hui , Liang Xian , Xing Shu , Huang Longjunjiang , Xie Fangting
Published: April 2023

This study uses field survey data from 382 families in the year 2020 in Jiangxi province, China, to explore the effects of land lease and labor migration, a well-known occurrence in China, on rural households’ multidimensional poverty status. We used the A-F method to measure the household’s multidimensional poverty in terms of health, education, income, living standard, and social relations. The Bootstrap Test approach, which worked well with our data, was used to build our mediating effect models while taking into account the influence mechanisms of land leasing and multidimensional poverty. According to our findings, 76.70% of sample homes experience multidimensional poverty at the threshold of 0.33. The reduction of multidimensional poverty is significantly aided by both leasing in and leasing out land. Land lease out and land lease in, however, have asymmetrical effects on multidimensional poverty alleviation, with the proportion of land lease out being 1.147 without control variables and the proportion of land lease in being 0.969 without control variables. Land lease in and lease out have positive effects on the multifaceted alleviation of poverty due to the mediating effect of labor migration. For policymakers to develop and put into action more relevant policies to help multidimensional poverty alleviation, our analysis offers critical insights.
Mitochondrial DNA Corroborates the Genetic Variability of Clarias Catfishes (Siluriformes, Clariidae) from Cameroon
Authors: Kundu Shantanu , De Alwis Piyumi S. , Binarao Jerome D. , Lee Soo-Rin , Kim Ah Ran , Gietbong Fantong Zealous , Yi Myunggi , Kim Hyun-Woo
Published: April 2023

The airbreathing walking catfish (Clariidae: Clarias) comprises 32 species that are endemic to African freshwater systems. The species-level identification of this group is challenging due to their complex taxonomy and polymorphism. Prior to this study, the biological and ecological studies were restricted to a single species, Clarias gariepinus, resulting in a biased view of their genetic diversity in African waters. Here, we generated the 63-mitochondrial Cytochrome c oxidase subunit 1 (COI) gene sequences of Clarias camerunensis and Clarias gariepinus from the Nyong River in Cameroon. Both C. camerunensis and C. gariepinus species maintained adequate intra-species (2.7% and 2.31%) and inter-species (6.9% to 16.8% and 11.4% to 15.1%) genetic distances with other Clarias congeners distributed in African and Asian/Southeast Asian drainages. The mtCOI sequences revealed 13 and 20 unique haplotypes of C. camerunensis and C. gariepinus, respectively. The TCS networks revealed distinct haplotypes of C. camerunensis and shared haplotypes of C. gariepinus in African waters. The multiple species delimitation approaches (ABGD and PTP) revealed a total of 20 and 22 molecular operational taxonomic units (MOTUs), respectively. Among the two Clarias species examined, we found more than one MOTU in C. camerunensis, which is consistent with population structure and tree topology results. The phylogeny generated through Bayesian Inference analysis clearly separated C. camerunensis and C. gariepinus from other Clarias species with high posterior probability supports. The present study elucidates the occurrence of possible cryptic diversity and allopatric speciation of C. camerunensis in African drainages. Further, the present study confirms the reduced genetic diversity of C. gariepinus across its native and introduced range, which might have been induced by unscientific aquaculture practices. The study recommends a similar approach to the same and related species from different river basins to illuminate the true diversity of Clarias species in Africa and other countries.
Diagnosis and Management of Cerebral Venous Thrombosis Due to Polycythemia Vera and Genetic Thrombophilia: Case Report and Literature Review
Authors: Jianu Dragos Catalin , Jianu Silviana Nina , Iacob Nicoleta , Dan Traian Flavius , Munteanu Georgiana , Gogu Anca Elena , Sadik Raphael , Motoc Andrei Gheorghe Marius , Axelerad Any , Sirbu Carmen Adella , Petrica Ligia , Ionita Ioana
Published: April 2023

(1) Background: Cerebral venous and dural sinus thrombosis (CVT) rarely appears in the adult population. It is difficult to diagnosis because of its variable clinical presentation and the overlapping signal intensities of thrombosis and venous flow on conventional MR images and MR venograms. (2) Case presentation: A 41-year-old male patient presented with an acute isolated intracranial hypertension syndrome. The diagnosis of acute thrombosis of the left lateral sinus (both transverse and sigmoid portions), the torcular Herophili, and the bulb of the left internal jugular vein was established by neuroimaging data from head-computed tomography, magnetic resonance imaging (including Contrast-enhanced 3D T1-MPRAGE sequence), and magnetic resonance venography (2D-TOF MR venography). We detected different risk factors (polycythemia vera-PV with JAK2 V617F mutation and inherited low-risk thrombophilia). He was successfully treated with low-molecular-weight heparin, followed by oral anticoagulation. (3) Conclusions: In the case of our patient, polycythemia vera represented a predisposing risk factor for CVT, and the identification of JAK2 V617F mutation was mandatory for the etiology of the disease. Contrast-enhanced 3D T1-MPRAGE sequence proved superior to 2D-TOF MR venography and to conventional SE MR imaging in the diagnosis of acute intracranial dural sinus thrombosis.