bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective Effect of Naringin in L-arginine-induced Acute Pancreatitis in Wistar Rats
Authors: Moznebi Esfahani Navid , Salimi-Tabatabaee Seyed Alireza , Karamali Fatemeh , Mirmalek Seyed Abbas , Shafagh Shima , Moussavi Nushin
Published: October 2024

Background: Acute pancreatitis is a non-infectious inflammatory disorder of the pancreas and a leading cause of hospitalization among gastrointestinal diseases, with up to 20% of patients experiencing morbidity and mortality. Naringin, a flavonoid found in fruits like oranges and tomatoes, has antioxidant and anti-inflammatory properties, making it useful in preventing and treating various diseases. This study aimed to investigate the effects of naringin on inflammation and oxidative stress in a rat model of pancreatitis. Materials and Methods: Sixty male Sprague-Dawley rats were divided into four groups. The control group received normal saline intraperitoneally (IP). Pancreatitis was induced in the sham and experimental groups using 3.2 g/kg of L-arginine IP, twice, with a one-hour interval. The experimental low dose (E-L) and high dose (E-H) groups were given 200 and 500 mg/kg of naringin IP, 30 minutes before L-arginine administration. Serum lipase, amylase, pancreatic IL-10, IL-1β, and TNF-α levels were measured. Oxidative stress markers such as superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and myeloperoxidase (MPO) were also evaluated, and histopathological examination assessed tissue damage. Results: The sham group showed increased amylase and lipase levels compared to controls. Naringin significantly reduced these levels in the experimental groups. It also decreased MDA and MPO levels and increased SOD and GSH activities. TNF-α and IL-1β levels were elevated in the sham group but were reduced with naringin treatment, which increased IL-10 levels in a dose-dependent manner. Histopathological analysis revealed a dose-dependent reduction in tissue damage severity with naringin. Conclusion: Naringin administration reduced pancreatic enzyme activity and enhanced antioxidant enzyme activities in rats with pancreatitis. It also demonstrated anti-inflammatory effects, decreased TNF-α and IL-1β levels, increased IL-10 levels, and showed protective effects against tissue damage, suggesting its potential as a therapeutic agent for pancreatitis-related complications.
Effect of Hiwa syrup, a Persian Medicine Product, on Autism Symptoms and in Children with Autism Spectrum Disorders: A Randomized Double-Blinded Clinical Trial
Authors: Dayani Mohsen , Karimi Mehrdad , Latifi Seied Amirhosein , Saberi Zafarghandi Mohammad Bagher , Salehi Mahdi
Published: October 2024

Background: Autism spectrum disorder (ASD) is a complex condition that affects communication, social interaction, and behavior. This study aims to evaluate the effectiveness of a Persian Medicine product, Hiwa syrup, which consists of consisted of apple (Malus domestica Borkh.) fruit, quince (Cydonia Oblonga Mill.) fruit, basil (Ocimum basilicum L.), green cardamom (Elettaria cardamomum), and sandalwood (Santalum album Linn), in ameliorating autism symptoms and extending eye contact duration in children diagnosed with ASD.
Methods: A double-blind randomized clinical trial involved 60 children (3-5 years) with level 1 autism, randomly assigned to intervention and control (placebo) groups. The intervention group received Hiwa syrup for eight weeks alongside routine therapy. Autism status was assessed using Persian version of Gilliam Autism Rating 2nd edition (GARS-2) questionnaire, and eye contact duration in response to auditory stimuli was measured pre and post-intervention. SPSS software version 25.0 was used for data analysis. 
Results: The Hiwa syrup group exhibited a significant decrease in the mean GARS-2 score from  75.03  ± 7.83 to 69.47 ± 5.87 (p=0.01) with a mean difference of 5.56 ± 3.12. This decrease surpassed that of the placebo group. Furthermore, the intervention group showed a significant increase in eye contact duration, from (7.90 ± 3.81 seconds to 9.26 ± 3.21 seconds (p=0.05), with a mean difference of 1.36±1.88 seconds. In contrast, the placebo group exhibited a smaller increase, from (7.50 ± 2.21seconds to 7.83 ± 2.91 seconds (p=0.64), with a mean difference of  0.33 ± 0.48 seconds.
Conclusion:The polyherbal product from Persian Medicine appears to be effective in ameliorating autism symptoms and extending the duration of eye contact in children diagnosed with autism spectrum disorders. Further clinical trials are essential to validate the efficacy of this product in treating autism spectrum disorders.
A New Species of Pacific Salmon – Rosy Salmon Oncorhynchus gorbuschka sp. nova: Description and Genesis of the Taxon
Authors: Glubokovsky M. K. , Zhivotovsky L. A.
Published: October 2024

Many years of comprehensive research in the morphological and genetic differentiation of pink salmon led us to the conclusion that there are two closely related cryptic Pacific salmon species in the North Pacific basin, which had previously been regarded as a single species of Oncorhynchus gorbuscha (Walbaum). A new species of Pacific salmon, the rosy salmon (as a colloquial name) O. gorbuschka sp. nova Glubokovsky et Zhivotovsky, occupies almost the same range as the nominate species pink salmon (as a colloquial name) O. gorbuscha (Walbaum). The most striking ecological difference of these species –rosy salmon spawns only in odd years, and pink salmon – only in even years, forming two reproductively isolated broodlines throughout the natural range. There are quite relief differences between them, that can be detected with the modern research methods, in demographic features, multidimensional morphological traits, protein and DNA markers, and full-genome profiles. Presumably, both of these species are relatively young, evolutionarily diverging from each other during sympatric allochronic evolution leading to a single age class. As a result, all sexually mature individuals of each broodline – of even and odd years of spawning (with rarest exceptions within the natural spawning range) – reproduce in river basins in exactly two years, dying soon after spawning. Presence of two species of O. gorbuscha requires their separate accounting at fundamental and applied researches, fishery and regulation of fishery, protection, artificial reproduction.
Quantitative analysis of factors influencing damage to old-growth hemiboreal stands as a result of a catastrophic windthrow, based on remote sensing and merged data
Authors: Ivanova N. V. , Shashkov М. P. , Lebedev А. V. , Shanin V. N.
Published: October 2024

The consequences of a catastrophic windthrow in a old-growth hemiboreal stands of the Kologrivsky Forest Reserve were investigated. The degree of damage to tree stands was assessed by interpretation of the Sentinel-2 satellite images. Data from the GBIF portal, SRTM global terrain height models, and tree stand heights were used for the quantitative analysis of factors affecting the presence of wind damage. It was found that tree stands on an area of 277.9 hectares (40.5% of the entire massif) were damaged by windthrow. The results of the analysis of height models and regression models showed that spruce stands are more vulnerable to wind damage, as well as stands of greater height or those growing at higher elevation on the ground.
Expansion of the area of the trematodes Paracoenogonimus ovatus (Katsurada, 1914) in Western Siberia
Authors: Zhokhov А. Е. , Kozhara А. V.
Published: October 2024

The distribution of trematodes Paracoenogonimus ovatus and its first intermediate hosts, viviparous Viviparus viviparus and V. contectus in the Ob–Irtysh basin were analyzed. Until the 1990s the spreading of P. ovatus in this region was associated with habitats of V. contectus, which is considered a native species in Western Siberia. Since the mid-1990s European species V. viviparus began to spread in the Ob basin. Before this, only one source of infection with P. ovatus was known associated with finding V. viviparus in the Lower Irtysh. This paper describes another such outbreak in the Tura River near the city of Tyumen. In fish from the Tura River, a generally high extent and intensity of invasion were noted. Further expansion of the range is predicted P. ovatus associated with expansion V. viviparus.
Analysis of Processes Accompanying Cylindrical Cumulation
Authors: Buravova S. N. , Belikova A. F. , Mukhina N. I. , Kopytsky V. O. , Petrov E. V. , Alymov M. I.
Published: October 2024

Flow contraction within cylindrical samples causes instability in motion, leading to the formation of circumferential compression stress. This then results in perturbations in the form of Mach three-shock configurations (protrusions) at the shock front. The area at the front of the perturbed shock wave increases due to these protrusions. Furthermore, the protrusions are amplified as a consequence of the absorption of smaller perturbations, which are continuously generated at the shock front. The shock front undergoes sharp growth at the final stage, giving rise to several large protrusions that divide it into separate sectors. These sectors undergo oscillatory movements. As the counter configurations collide, a high-pressure zone is generated, which propels some of the compressed material forward. The protrusions reach their maximum height when they become equal to the distance of the front to the axis. The near-axis region is taken up by the frontal protrusions, and the consequent rarefaction shock wave decelerates the incoming flow.
Equatons of State for Regolith and Chondrite at High Pressure
Authors: Lomonosov I. V.
Published: October 2024

Using the principle of additivity under shock compression, wide-range equations of state of regolith and ordinary chondrite for the high-pressure region are constructed.
Generalized Brenier Principle and the Closure Problem of Landgren–Monin–Novikov Hierarchy for Vorticity Field
Authors: Grebenev V. N. , Grishkov A. N.
Published: October 2024

Brenier’s concept – a representation of solutions to the equations of ideal incompressible fluids in terms of probability measures on the set of Lagrangian trajectories in the case of their stochasticity, is a generalization of Arnold’s principle of least action of finding smooth solutions of Euler’s equations. In this work, the variational generalized Brenier principle (Brenier, J. Am. Math. Soc. 1989) is used to close the infinite chain of Landgren–Monin–Novikov equations for the n-point probability density functions fn of the vortex field of two-dimensional turbulence. In addition, within the framework of the statistical approach, an approximation of the variational problem with conditions at the ends posed by Shnirelman (Mat. Sat. 1985) for the Euler equation is proposed.
Estimation of Water-Like Bottom Length along an Acoustic Track in Shallow Water
Authors: Sidorov D. D. , Bodjona S. D. , Petnikov V. G. , Lunkov A. A.
Published: October 2024

Analytically and within the framework of numerical simulations, remote sensing of the water-like bottom in shallow water based on low-frequency sound propagation loss is considered. Water-like bottom sediments are understood as sediments in which the sound speed is close to the sound speed in water, but having a significantly higher density. A model statistical analysis of depth-averaged transmission loss is carried out for acoustic tracks of a fixed range in one of the areas of the Kara Sea with a known structure of the upper layer of the bottom, which includes water-like areas. A good correlation between low-frequency transmission loss and the length of water-like bottom is demonstrated. Based on this result, a method for remote integral estimation of the water-like bottom size at an acoustic track between a single source and a vertical array of hydrophones is proposed.
Porte-chaises and Gazebos in the Traditions of European Horse-Drawn Transport of the Baroque Era
Authors: Shkolna Olha , Kovalchuk Ostap
Published: October 2024

The aim of the article is to determine the constructive, compositional and artistic features of porte-chaises and gazebos in the European proto-design of the Baroque era. Results. It has been found that among the horse-drawn transport of the Baroque period in European proto-design, a special place was occupied by carriage carriers, which were carried by special porters, following the example of ancient oriental prototypes. The author reveals that this tradition was initiated under the influence of interaction with the Indian Raj and other representatives of the Eastern establishment and developed among the high society circles of nobility in England, Spain, Italy, and France as a reflection on colonial ambitions in society. The scientific novelty of the study is related to the analysis of constructive, compositional and artistic features of gazebos and porte-chaises in the European tradition of horse-drawn transport of the seventeenth and eighteenth centuries on the example of monuments that have been preserved or recorded by artists. Conclusions. It has been proved that the production of baroque portable carriages such as porte-chaises and gazebos was carried out by individual specialists-woodcarvers. They knew how to combine metal and wooden structures of the product’s frame, as well as how to design the “salon-cabin” using different types of leather and drapery fabrics. The ways of external decoration of such objects with a representative heraldic coat of arms compositions, bouquets of flowers, and plot motifs are outlined. The article illustrates the varieties of porte-chaises, gazebos, sedan chairs, palanquins, and sigettes (sigetter, “vastasi di cinga”) typical of the seventeenth and eighteenth centuries in the works of European painters.
Conceptualism of Sculpture Films of the 1970s–1980s in the Experimental Field of “Expanded Cinema”
Authors: Anhelova Anhelina
Published: October 2024

The aim of the article is to analyse conceptual foundations of sculpture films in the 1970s–1980s in the context of experiments with “cinema expansion”. Results. Sculpture films of the 1970s–1980s show signs of a tendency toward conceptualism inherent in postmodern art. In innovative experiments on the audiovisual art and sculpture synthesis, not only the updated artistic toolkit became basic, but the process of meaning creation with a mandatory appeal to the audience’s perception as well. All this was organically integrated into the general search of avant-garde directors, aimed at developing the technological and artistic possibilities of cinematography, which received a generalised name “expanded cinema” (G. Youngblood). W. Turnbull, A. Forbes, D. Ashton, R. Horn, V. Pye, G. Matta-Clark, L. Lijn, B. Flanagan, R. Smithson, G. Stevens, P. Dockley, D. Hall, D. Dye, E. McCall, L. Lye, J. Hilliard, T. Hill, and many others, can be considered the figures in this direction. Scientific novelty. For the first time, the conceptual foundations of sculpture films of the 1970s–1980s are systematically analysed in the context of avant-garde searches by masters in creating interdisciplinary arts, and in extended cinema as well. Conclusions. The analysis of projects significant for sculpture cinema in the 1970s–1980s reveals a few conceptual creative approaches: video documentation of the process of creating a sculpture, and presenting an audiovisual work as an independent art object; filming the transformation and destruction of sculpture works for the purpose of provocative statements on current topics; use of cinematographic equipment as a material for creating sculptures; expanded interpretation of the concept of “sculpture” as a form, the construction of which is not limited to solid materials or inanimate objects; fixation on film of kinetic sculptures, the contemplation of which is inseparable from the surrounding environment. A general conclusion is made that experiments with sculpture films contributed to the video art formation, and influenced the further development of media art.
APPLICATION OF GRADIENT DEFORMATION CRITERION
FOR ANALYSIS OF THERMOMECHANICAL DESTRUCTION OF REFRACTORIES
IN A TEMPERATURE FIELD
Authors: Zabolotskii A.V. , Dmitriev A.I.
Published: October 2024

An approach to the analysis of refractories thermomechanical destruction in service under the influence ofrapid temperature change, called as thermal shocks, is proposed. The proposed approach, based on sequential calculations of the temperature field in the refractory lining and the fields of elastic thermal deformations of the material, performed by the finite element method. The obtained results processed using the deformation gradient criterion of brittle fracture introduced by the authors.The introduced criterion allows identify zones of onset of crack formation, determine the moment of the onset of destruction and predict the direction of crack growth, using of the dynamic calculation of temperature fields in the lining and the calculation of the corresponding static fields of elastic deformations of materials. In addition, the temperature dependence of the elastic properties of refractory materials taken into account, a feature of which is a change in the nature of destruction from brittle to plastic at operating temperatures close to the phase transition temperature of the refractory material or any of its components.Various options for installing products in linings and the corresponding fields of elastic deformations that arise during a sharp rise in temperature in the unit considered. Sharp one-sided heating of one of the lining surfaces is the most dangerous stage of operation of high-temperature equipment from the point of view of thermomechanical stresses.An assessment of the average speed of crack propagation and the possibility of stopping it during the growth process subsequently carried out by analyzing the energy state of the vicinity of the crack tip by comparing the energy of elastic deformation of the material region with the surface energy of the growing defect. The practical application of the approach and validation of the research results considered using the example of a typical failure of the working lining of a steel-pouring ladle.
MATERIAL CONSTANTS OF TRIGONAL
SYNGONY PYROPIEZOELECTRICS UNDER THE INFLUENCE
OF PHYSICAL FIELDS OF DIFFERENT NATURE
Authors: Belyankova T.I. , Kalinchuk V.V. , Lomakina L.V.
Published: October 2024

The article studies the previously proposed model of a prestressed thermoelectroelastic medium of class 3m trigonal syngony under the action of initial mechanical stresses, an electrostatic field at a given temperature. The model is based on linearized constitutive relations constructed within the framework of sequential linearization of nonlinear equations of continuous medium electrodynamics. Linearization is carried out within the framework of superimposing small deformations on final ones with preservation of high-order terms in the equation of state. When constructing a model based on the use of linearized constitutive relations, it is taken into account that it is impossible to use the Voigt notation, which is usual for the natural state, in this case. Within the framework of this model, the behavior of the material constants of a thermoelectroelastic medium of class 3m trigonal syngony is studied. It is shown that, unlike electrical and mechanical effects, the thermal factor linearly affects the constants: preheating leads to an increase in the elastic constants, cooling – to their decrease. The effect on the piezoelectric constants is also linear, but more complex: some constants increase, others decrease. In this case, the possibility of using the Voigt notation, which is usual for the natural state, is preserved. Mechanical and electrical effects lead to the separation of constants coinciding in the natural state; in this case, the use of the Voigt notation, which is usual for the natural state, is impossible. The decomposed constants depend nonlinearly on mechanical stresses, but linearly on the electrostatic field. The nature and magnitude of the change in the constants depend both on the type of mechanical action and on the polarity of the electrostatic field. It should be noted that in this work, the effect of minor thermal effects was investigated. The effect of high initial temperatures significantly changes the properties of the material, but goes beyond the linearized theory and requires the use of nonlinear relationships.
MODELING OF VIBRATIONS OF A STACKED PIEZO ELEMENT
MADE OF POROUS PIEZOCERAMICS
Authors: Soloviev A.N. , Germanchuk M.S. , Oganesyan P.A.
Published: October 2024

The work is devoted to a numerical study of the effectiveness of using porous piezoceramics in a stacked piezoelectric element, which can be used as a power drive element, a piezoelectric generator, or an ultrasonic emitter. The use of porous piezoceramics in stacked piezoelements has not received enough attention in the literature. The use of porous piezoceramics in stacked piezo elements has not received enough attention in the literature.
The paper considers a stacked piezo element consisting of eight solid cylinders counter-polarized in the axial direction. The material of the cylinders is PZT-4 piezoceramic, the porosity of which varies from 0% to 80%. The problem of axial steady-state oscillations in the vicinity of the first resonance frequency and below it is solved. The lower end of the cylinder is fixed along the normal, excitation of oscillations is carried out by mechanical action under uniformly distributed pressure at the upper face or by the action of electric potential difference at the electrodes. The problems are solved in the framework of linear axisymmetric theory of electroelasticity. With mechanical action, the output characteristic of the device is the electrical potential of the free electrodes; with electrical action, it is the amplitude of the axial vibrations of the upper end or the reaction force if it is fixed.
The finite element method implemented in the ACELAN package is used as the solution method. As a result of the numerical solution, the dependence of the percentage of porosity on the output characteristics of the piezo element is investigated: the frequencies of resonance and antiresonance, the electromechanical coupling coefficient, the output potential under mechanical loading, the amplitude of oscillations of the free upper end and the coupling reaction at its fixing when the oscillations are excited by the potential difference and the energy of the elastic element attached to this end. The analysis of the dependence of these characteristics allows us to conclude that it is reasonable to use such an element with porous ceramics as a piezoelectric generator and transmitter. It is noted that the choice of the percentage of porosity depends directly on the intensity of loads and the strength of porous piezoceramics.
Encapsulated papillary carcinoma of breast: Comparative study of multimodal ultrasound manifestations and pathological features
Authors: Wu Zehong , Li Huajuan , Chen Zihao , Zhou Honglian , Liang Xin , Huang Xing , Wang Jiexin , Chen Ting , Xu Xiaohong , Yang Yuping
Published: October 2024

OBJECTIVE: To investigate the conventional ultrasound (US), contrast-enhanced ultrasound (CEUS) manifestations and the corresponding histopathological characteristics of patients diagnosed with breast encapsulated papillary carcinoma (EPC) and to explore the value of CEUS in diagnosis of EPC. METHODS: The clinical, pathological, US, and CEUS features of 16 patients (17 lesions) with EPC confirmed by postoperative histopathology were retrospectively analyzed. RESULTS: EPC was prevalent in the postmenopausal women. The majority of conventional US images of EPC showed complex cystic and solid masses with circumscribed margins (70.6%), enhanced posterior echo (94.1%), no sonographic calcification (88.2%), rich blood flow in the solid components within lesions (70.6%) on Color Doppler flow imaging, and high resistance index of blood flow (94.1%). Moreover, CEUS showed mainly centripetal hyperenhancement of the solid components within the lesions with irregular outline, and the enhancement area of the whole masses was essentially the same as the B-mode US area. CONCLUSIONS: EPC typically presents as a complex cystic and solid mass. CEUS is helpful to clarify the extent of the solid component and facilitate preoperative core-needle biopsy. A comprehensive evaluation by CEUS is valuable for diagnosing EPC and combining it with clinical features are helpful to further improve the diagnosis of this rare kind of breast cancer.
Mortality Risk for Individuals With Cocaine Use Disorders: Clients and Non-Clients of Public Treatment Centres for Drug Addiction
Authors: Pavarin Raimondo
Published: October 2024

BACKGROUND: This study targeted individuals who turned for the first time to health services following problems caused by cocaine use (CUD). Our aim was to estimate mortality risk for individuals who were clients of PATS (public addiction treatment services) and never-PATS (those who were not).

METHOD: Follow-up study. People resident in Emilia Romagna Region (Northern Italy), aged 18 years and older who for the first time turned to a HOS (hospital ward), an ED (emergency department), a MHS (community mental health centre) or to a PATS for cocaine use disorder were selected. The reference period was between 01/01/2009 and 31/12/2019 and the territory was the metropolitan area of Bologna. CMR (Crude mortality rates) per 1000 PY (Person Years) and SMRs (standardized mortality ratios) were calculated.

RESULTS: The cohort was made up of 3,196 subjects. CMR was 4.5 (95% CI 3.6-6.6) per thousand patient/years, SMRs were 4.3 (95% CI 3.5-5.4). The results highlight high CMRs (5.5, 95% CI 3.8-8.1) and SMRs (4.7, 95% CI 3.2-6.9) for individuals who never accessed PATS.

Higher and statistically significant incidence rate ratios were found from the multivariate analysis among females and natives, in patients never accessed to PATS, aged more than 35 years and reporting using alcohol or opioids at first admission.

CONCLUSIONS: Innovative strategies to facilitate the reduction of barriers to access and to facilitate taking charge in PATS for people with cocaine use disorders must be identified.
FDA Decision to Authorize NJOY ACE Menthol Was Based on a Rigorous Review of the Science to Determine That the Benefits Outweigh the Risk
Authors: Sarkar Mohamadi
Published: October 2024

Response to the article written by Rita Rubin, “Controversial FDA Decision Authorizes Menthol-Flavored E-Cigarettes Despite Risks” JAMA. 2024 Aug 7. doi: 10.1001/jama.2024.14243 [https://doi.org/10.1001/jama.2024.14243]. Online ahead of print.
Efforts to Prevent Low Back Pain in Skewer Craftsmen in Botosari Hamlet, Dukuhmencek Village, Jember Regency
Authors: Adriani Sri Wahyuni , Purwaningsih Retno Ayu , Masturi Indriyani Oktavia , Nuraini Dyah Fita , Pradana Antony , Bibi Safira , Agustin Dwi , Adriani Sri Wahyuni
Published: October 2024

Low back pain (LBP) is pain felt in the lower back, is not a disease or diagnosis for a disease but is a term for pain felt in the affected anatomical area with varying lengths of pain. Low back pain occurs due to incorrect working positions or vertebral loading that is three times heavier than in a standing position. The problem of low back pain arising from prolonged sitting is a frequent phenomenon at this time. Skewer craftsmen are at risk of Low Back Pain disease because they need a long time to sit. This counseling activity aims to make the skewer craftsmen know and understand about the prevention of Low Back Pain. The material presented contains understanding, causes, signs and symptoms, and prevention of Low Back Pain. The evaluation was carried out by giving questions in the form of pretests and posttests containing the same 10 questions and given to respondents to measure the level of knowledge before and after counseling. Based on the pretest and posttest that has been done, the results show that there is an increase in understanding in the skewer artisan community regarding Low Back Pain (LBP).
PROMOSI KESEHATAN TENTANG VAGINISMUS MELALUI MEDIA SOSIAL
Authors: Sutjiato Valencia Yuniarti , Sari Damarra Kartika , Suwae Reynold Habel , Putri Raja Nadira Shaheila
Published: October 2024

Penelitian ini membahas tentang promosi Kesehatan terkait isu kesehatan reproduksi melalui Instagram, khususnya pada penyakit vaginismus di Indonesia. Vaginismus merupakan penyakit yang penting dibahas karena minimnya pengetahuan masyarakat terkait hal ini dan menimbulkan stigma negatif bagi para penderita. Penelitian ini menggunakan metode deskriptif kualitatif dan data dikumpulkan melalui observasi. Hasil penelitian menunjukkan bahwa ada dua sisi pembahasan isu vaginismus: masalah medis dan sosial. Media sosial dipakai sebagai sarana untuk melakukan promosi kesehatan dan edukasi kepada masyarakat untuk tidak memberikan stigma kepada penderita vaginismus.
UPAYA MENINGKATKAN KESADARAN PUBLIK MELALUI DIFFUSI PROMOSI CERUTU JEMBER DI PT TARUTAMA NUSANTARA
Authors: Damayanti Resvindira
Published: October 2024

This research aims to identify and analyze the efforts made to increase public awareness through the diffusion of Jember cigar promotion at PT Tarutama Nusantara. With increasing competition in the cigar market, it is important to understand how promotions can be an effective tool in increasing public awareness of cigars in Jember Regency. The rationale for this research is based on the diffusion of innovation theory and marketing communication theory, which emphasizes the importance of effective communication in influencing consumer perceptions and behavior. The methodology used is a qualitative approach, by collecting data through in-depth interviews with subman related to the promotion of Jember cigars at PT Tarutama Nusantara and the general public regarding the existence of cigars. Research findings show that PT Tarutama Nusantara has used various promotional strategies, including advertising, event sponsorship, and sales promotions to increase public awareness of cigars. However, there are still challenges in promotional effectiveness, such as consumer preferences or choices, price and lack of adequate mass media exposure. Therefore, this research provides recommendations for improving internal coordination and market research regarding public awareness regarding the existence and superiority of cigars in Jember Regency. It is hoped that the results of this research can provide valuable insight for PT Tarutama Nusantara and other companies in the cigar industry to increase public awareness and optimize their promotional strategies.
Keyword: Jember Cigars; Promotion; Tarutama Nusantara
STRATEGI BRANDING KAMPOENG KREATIF BINAAN YAYASAN JEMBER FASHION CARNAVAL DI TAMAN KOTA ARJASA
Authors: Widianto Dimas Rizki , Kukuh Pribadi
Published: October 2024

Penelitian ini mengkaji strategi promosi yang diterapkan oleh Kampoeng Kreatif, sebuah program binaan Yayasan Jember Fashion Carnaval (JFC) yang berlokasi di Taman Kota Arjasa, Jember. Tujuan penelitian adalah untuk mengidentifikasi dan menganalisis pendekatan yang digunakan dalam membangun citra dan identitas Kampoeng Kreatif sebagai pusat kreativitas dan pengembangan industri kreatif di Jember. Metode penelitian yang digunakan adalah kualitatif deskriptif, dengan pengumpulan data melalui wawancara mendalam, observasi lapangan, dan studi dokumentasi. Informan penelitian meliputi public relations Kampoeng Kreatif, warga setempat, dan kepala bidang pariwisata dari dinas pariwisata dan budaya Kabupaten Jember. Hasil menunjukan bahwa ada beberapa strategi promosi yang diterapkan seperti penggunaan media sosial, marketing event, serta pembuatan paket wisata. Tentunya hal ini akan menunjang branding dari Kampoeng Kreatif JFC Arjasa.
The first Russian external loan and the participants in its implementation
Authors: Lizunov P. V. , Morozan V. V.
Published: October 2024

The article is devoted to the first Russian loan made on the international money market. Having entered into another war with Turkey in 1768, Russia turned out to be economically poorly prepared for this conflict. Limited financial resources forced the tsarist authorities to search for sources of support for this campaign. In this regard, the government took various steps to stabilize the country’s financial situation, and implemented a plan for the transition to paper money circulation with the issue of significant volumes of banknote rubles. To ensure military expenses associated with the maintenance of the Russian fleet in the Mediterranean and strengthening the exchange rate of the Russian ruble, the government implemented in 1769—1773 the first domestic loan in the amount of 7,500 thousand guilders on the Dutch money market. The article discusses the process of producing the said loan and the participants in this monetary transaction. Two banking houses took part in its implementation. On the part of the Russian government, one of the first court bankers, Ivan Yuryevich Fredericks, spoke. On the Dutch money market, the brothers Raymond and Theodor de Smet were involved in the sale of Russian loans. They are credited with the success of this operation.
Changes in antitrust regulation and merger activity in Russia: Price manipulations and need for additional antitrust scrutiny
Authors: Markova O. A. , Stavniychuk A. Y.
Published: October 2024

Antitrust regulation is constantly evolving that enables the Federal Antitrust Service of Russia to timely respond to new economic and technological changes. The latest amendments to the antitrust law which came into force on September 1, 2023 include changes to the regulation of mergers and acquisitions and add a new criterion for a deal approval. In this study, we evaluate short-term effects of the changes in antitrust merger regulation and identify stealth mergers. We use data from the mergers.ru (Mergers and Acquisitions in Russia) to test hypotheses about possible effects of regulatory changes. We use the McCrary test (manipulation test) to reveal if there is continuity in the distribution of mergers prices and find a persistent discontinuity at the new threshold for deal price (7 billion rubles) both after the adoption of the amendments (from June 27, 2023) and after their implementation (from September 1, 2023). This may indicate the presence of manipulations in deal prices, which in the future can possibly lead to higher prices and distortions in innovation efforts.
A gamifikáció eszközei és alkalmazásuk lehetőségei a településfejlesztési folyamatokban
Authors: Tóbiás Katinka
Published: October 2024

A várostervezés szempontjából korunk egyik legnagyobb társadalmi problémája az ösztönzés egyre nehezebbé válása. Ez a jelenség nemcsak az oktatásban, hanem a közösségi tervezési folyamatokban is erősödik. A motivációt célzó új jelenség és módszertan, a gamifikáció megoldást kínálhat erre a problémára. Csupán az elmúlt néhány évben nőtt jelentős mértékben a tudományos kutatás ezen a területen, főként nemzetközi szinten és az oktatás területén, de egyre több a jó gyakorlat a részvételen alapuló városfejlesztés játékosítása terén is. A magyar gyakorlatban azonban még nem elterjedt, és nem feltétlenül beszélhetünk tudatos gamifikációról sem a játékos események esetében. A korábbi kutatások alapján a releváns játékok tartalomelemzése készült. Ennek eredményeként összeállítottam egy gamifikációs eszköztárat, amely három fő kategóriába sorolható: játéktervezési elemek, szoftveres elemek és tárgyi eszközök. Ezek megfelelő és összehangolt átvételével lehetőség nyílik a városfejlesztés játékosítására, a közösségi tervezés szerepének és hatékonyságának növelésére, az lakossági motiváció és részvétel növelése érdekében.
MIÉRT NINCSENEK AKTÍV, OLDÓDÁSOS (DRAWDOWN) DOLINÁK A DUNÁNTÚLI-KÖZÉPHEGYSÉGBEN?
Authors: Unger Zoltán , Veress Márton
Published: October 2024

Az epikarszt fejlettsége és a felszíni formakincs kapcsolatát elemezzük karsztterületeken a célból, hogy a Dunántúli.középhegységben az oldódásos dolinák hiányának okát értelmezzük. Ehhez a vizsgálatba bevont karsztterületek feküjének VESZ mérésekkel az átlagos fajlagos ellenállásait hasonlítjuk össze. Megállapítható, hogy a Bakonyvidéken, ahol nincsenek oldódásos dolinák az ellenállások a feküben kicsik és ez vízben gazdag epikarsztra utal (vagy másképpen a vizes rész magasabban van), míg a többi vizsgált karsztterületen, ahol vannak oldódásos dolinák, az ellenállások nagyok, ezért a területek epikarsztja vízben szegény (vagy annak vizes része mélyebben van). Kicsi ellenállásnál, ahol a piezometrikus felszín magas helyzetű, az epikarszt fejletlen, ami nem kedvez a dolinaképződésnek. Nagy ellenállásoknál a piezometrikus felszín mélyebben van (a behatolások nem érték el az epikarszt vizes részét), ezért az epikarszt fejlett, ami kedvezett az oldódásos dolinák képződésének.
Discovery of bioactive secondary metabolites from benthic filamentous marine cyanobacteria
Authors:   , Salleh Nurul Farhana
Published: October 2024

The main objective of this MSc research was to discover marine natural products from filamentous marine cyanobacteria. These marine cyanobacteria samples were collected from various islands around Singapore such as Pulau Hantu Kechil, Lazarus and St. John’s Islands. The preliminary analysis of the extracts from these samples indicated interesting chemistry based on NMR and preliminary cytotoxicity assays. Henceforth, the chemistry and biological activities of the compounds isolated from these samples will be further discussed in the following chapters.

In Chapters 1 to 3, it covers an introduction on the importance of marine natural products, filamentous marine cyanobacteria, and molecular networking in a natural product research. These chapters would support the purpose of conducting investigations on marine natural products coming from filamentous marine cyanobacteria.

Chapter 4 covers the marine natural products that have been isolated from Pulau Hantu Kechil, which are known compounds, lyngbyatoxin A (1), majusculamides A (2) and B (3) from the filamentous marine cyanobacteria Lyngbya majuscula. These compounds were then further investigated for its biological activities to determine if it supports literature. Further investigations by molecular networking were then conducted to determine if potential analogues of these compounds are present.

Chapter 5 describes the discovery and structural elucidation of lazarusamate (4), which is a linear lipopeptide isolated from the filamentous marine cyanobacteria Symploca sp. collected from Lazarus Island. Biological activities of the compound are also reported in this chapter. Molecular networking analysis was also conducted for this compound to determine presence of potential analogues.

The last working chapter, Chapter 6, then describes the discovery and structural elucidation of benderadiene (5), which is a cyclopropyl containing compound isolated from the filamentous marine cyanobacteria Lyngbya majuscula cf., collected from St
John’s Island. Biological activities of this compound were also reported and discussed, and a preliminary molecular docking experiment was conducted on Swissdock to further support the biological activity which the compound exhibited.

Last but not least, the final chapter concludes the thesis which summarises the discovery of filamentous marine cyanobacterial compounds and potential future works.
Penerapan Pewarnaan Graf Menggunakan Algoritma Welch-Powell pada Penjadwalan Mata Pelajaran
Authors: Yusak Monica Yeyen , Putri Desi Febriani , Syaripuddin Syaripuddin
Published: October 2024

Penjadwalan mata pelajaran adalah unsur penting dalam manajemen sekolah yang efisien. Pewarnaan graf digunakan sebagai pendekatan untuk menyelesaikan permasalahan pada proses penyusunan penjadwalan menggunakan algoritma welch-powell. Pada penelitian ini, dilakukan peenjadwalan penyusunan mata pelajaran di SMP Terpadu Rea Kaltim Kembang Janggut menggunakan pewarnaan graf. Algoritma yang digunakan adalah algoritma welch-powell, untuk menyusun penjadwalan yang meminimalkan bentrok antara mata pelajaran yang memiliki jadwal tumpang tindih. Penelitian ini bertujuan untuk mengetahui model mata pelajaran dan guru pengampu kedalam bentuk graf, serta untuk mengetahui hasil dari pewarnaan graf menggunakan algoritma welch-powell di SMP Terpadu Rea Kaltim Kembang Janggut. Penelitian ini berfokus pada pewarnaan titik menggunakan algoritma welch-powel, jadi untuk setiap titik yang bertetangga tidak boleh memiliki warna yang sama. Data pada penelitian ini mencakup informasi tentang guru pengampu mata pelajaran, jumlah kelas, dan jumlah mata pelajaran. Berdasarkan hasil penelitian diketahui bahwa pewarnaan graf dengan algoritma welch-powell dapat digunakan pada penyusunan penjadwalan mata pelajaran SMP Terpadu Rea Kaltim Kembang Janggut. Pada implementasi pewarnaan graf diperoleh bilangan kromatik adalah 5 atau   yang terdiri dari warna merah, kuning, hijau, ungu, dan biru.
Pengaruh Model Pembelajaran Teams Games Tournament (TGT) Berbantuan Kahoot terhadap Kemampuan Komunikasi Matematis Siswa
Authors: Wulandari Anisa , Hendrastuti Zuida Ratih , Krisma Dita Aldila
Published: October 2024

Tujuan penelitian ini yaitu untuk menelaah ketuntasan klasikal kemampuan komunikasi matematis siswa yang diterapkan model TGT berbantuan Kahoot, menelaah ketuntasan klasikal kemampuan komunikasi matematis siswa yang diterapkan model pembelajaran langsung dan menelaah kemampuan komunikasi matematis siswa yang diterapkan model TGT berbantuan Kahoot lebih baik dari model pembelajaran langsung. Metode penelitian ini yaitu quasi experiment dengan teknik cluster random sampling. Sedangkan pengumpulan data dilakukan dengan observasi, wawancara, tes serta dokumentasi. Didapatkan hasil dari penelitian ini yaitu kemampuan komunikasi matematis siswa yang diterapkan model pembelajaran TGT berbantuan Kahoot dan kemampuan komunikasi matematis siswa yang diterapkan model pembelajaran langsung mencapai ketuntasan klasikal sebesar 90%. Sementara itu kemampuan komunikasi matematis siswa yang diterapkan model pembelajaran TGT berbantuan Kahoot lebih baik dibandingkan kemampuan komunikasi matematis siswa yang diajar dengan model pembelajaran langsung dengan nilai t_hitung = 2,230 > t_tabel = 1,671.
РОЛЬ РЕІНЖИНІРИНГУ В РОЗВИТКУ БІЗНЕС-ПРОЦЕСІВ, ІННОВАЦІЙНОГО МЕНЕДЖМЕНТУ ТА МАРКЕТИНГУ ПІДПРИЄМСТВ
Authors: Бабенко Ірина , Большая Оксана , Іщенко Інна , Харченко Наталія , Школяр Сергій
Published: October 2024

У статті розглянуто поняття та властивості бізнес-процесів на сучасних підприємствах, обґрунтовано технологічні аспекти та роль реінжинірингу в розвитку бізнес-процесів, інноваційних менеджменту та маркетингу сучасних компаній. Деталізовано напрямки реінжинірингу залежно від концепції менеджменту підприємства. Доведено, що своєчасний та ефективний реінжиніринг забезпечує підвищення рентабельності та маржинальності підприємства, шляхом зміни системи управління окремих бізнес-процесів чи окремих циклів, підходів до кадрової політики та системи мотивації праці, забезпечення високої якості продукції та зменшення її собівартості. Реінжиніринг бізнес-процесів знижує витрати та тривалість циклу і рівень помилок. Проаналізовано перешкоди та недоліки реінжинірингу: нехтування попередніми здобутками компанії, інгуманність, витрати часу та матеріальних засобів.
ANALISIS EFEKTIFITAS DAN KONTRIBUSI PEMUNGUTAN PAJAK RESTORAN, REKLAME, DAN PENERANGAN JALAN PADA PAD KABUPATEN PEKALONGAN
Authors: Furqon Imahda Khoiri , Faturrokhman Muhammad Luki
Published: October 2024

Total dari semua pajak kota, retribusi, berbagai biaya manajemen aset lokal, dan aliran pendapatan tambahan disebut sebagai pendapatan daerah. Pajak daerah antara lain mencakup pajak restoran, reklame, dan penerangan jalan. Penerangan jalan, restoran, dan reklame merupakan industri yang memungkinkan untuk meningkatkan efektivitas penerimaan pajak dan mendorong pertumbuhan ekonomi di Kabupaten Pekalongan. Penelitian ini memeilki tujuan untuk mengevaluasi efektivitas dan kontribusi pajak penerangan jalan, restoran, dan reklame terhadap PAD Kabupaten Pekalongan. Dinas Pendapatan Daerah Kabupaten Pekalongan menjadi lokasi penelitian. Informasi mengenai realisasi pajak penerangan jalan, pajak reklame, dan pajak restoran dari tahun ke tahun 2019 dan 2020 dikaji dengan menggunakan pendekatan analisis deskriptif. Secara keseluruhan, pajak reklame, pajak penerangan jalan, dan pajak restoran sangat efektif pada tahun 2019 dan 2020. Pendapatan dari pajak penerangan jalan, pajak reklame, dan pajak restoran memberikan pengaruh yang positif kepada PAD pada tahun 2019-2020. Para pemimpin DISPENDA harus berdedikasi untuk mencapai tujuan tahunan dan bekerja untuk meningkatkan jumlah pengaruh restoran, reklame, dan penerangan jalan terhadap PAD.
Kata kunci: PAD, pajak daerah, efektifitas, kontribusi
EFFECT OF BLENDED LEARNING EDUCATIONAL MODEL ON SECONDARY SCHOOL STUDENTS’ MATHEMATICS CONCEPTUAL UNDERSTANDING
Authors: Abdissa Dinkissa Gofer , Duressa Gemechis File , Olkaba Teklu Tafase , Feyissa Eyasu Gemechu
Published: October 2024

The study was conducted to assess the effect of a blended learning educational model on grade ten students' mathematics conceptual understanding in Ethiopia. A non-equivalent pre-test and post-test quasi-experimental design was employed. Two intact classes from different schools were randomly selected and assigned to experimental (n=38) and comparison group (n=45). From the previous semester, students’ record book revealed that both groups have almost an equivalent mathematics performance. A one-way ANOVA and paired sample t-test were used to analyze the data. Moreover, to check the equivalence of the groups, the same pre-test was developed and administered. The result indicates that both groups were equivalent. The test covers tenth-grade topics relations and functions, polynomial functions, exponential functions, and logarithmic functions. The study shows that students instructed through the blended learning approach surpassed those taught via the conventional method in their comprehension of mathematical concepts. The one-way ANOVA statistical result revealed there is a notable disparity between groups with effect size of η2 =.269, which is a large effect size. Moreover, a paired sample t-test shows the experimental group showed a substantial mean difference of 14.327 with a very large effect size (d=1.016) when compared with the comparison group. Thus, the study shows that blended learning was more effective in improving mathematical conceptual understanding when compared with a conventional method of teaching. Based on the findings, the researcher recommends blended learning in mathematics education and suggests stakeholders and policymakers incorporate the model into the curriculum.
Keywords: blended learning, conceptual understanding, educational model, lab rotation model, mathematical concept