bluuebunny/crossref_metadata_2025 huggingface dataset:
Pola dan Narasi Gerakan Keislaman di Universitas Negeri Jakarta
Authors: Hakam Ahmad , Anggraeni Dewi , Fadhil Abdul
Published: August 2020

Tujuan penelitian ini mengkaji mengenai pola dan narasi gerakan keislaman yang ada di UNJ. Metode penelitian ini kualitatif dengan pendekatan studi kasus. Hasil penelitian ini menunjukkan bahwa terdapat dua tipe gerakan keislaman di UNJ berupa gerakan nasional dan transnasional. Pola gerakan keislaman nasional berupa kegiatan akademik keagamaan melalui Program Studi PAI, dan organisasi ekstra kampus MATAN, sedangkan gerakan keislaman transnasional diwakili oleh Lembaga dakwah kampus (LDK), serta organisasi ekstra kampus meliputi KAMMI, BMCI, dan Nyantrend. Narasi yang dibangun oleh Prodi PAI dalam bentuk kegiatan akademik keagamaan adalah moderasi Islam dengan jargon “lebih moderat makin Indonesia”,  MATAN sebagai gerakan Islam nasional membangun mengusung narasi keislaman  Islam Rahmanatn Lil Alamin, LDK mengusung syumuliatul Islam, KAMMI membangun narasi keislaman dengan Islam  Syamil, BMCI narasi keislaman yang didakwahkan berupa Islam Kaffah sedangkan Nyantred membangun narasi keislaman berupa Islam Ahlu Sunnah.
Interactive E-Learning Courses as a New Teaching Method
Authors: Sodiqovich Usmonov Murod , Burxonovich Abdullayev Xolxuja , Mamarasulovich Suvonqulov Baxtiyor
Published: August 2020

This article discusses the use of interactive training courses, their features, differences from ordinary training courses. The article also develops a model of a multimedia interactive e-learning course and discusses its advantages.
Dampak Model Kooperatif Tipe TGT (Teams Games Tournament) Terhadap Motivasi Belajar Siswa Kelas II SD
Authors: Lilis Mustofiyah  , Firdaus Su’udiah
Published: August 2020

This study aims to determine the effect of the TGT type cooperative model (Teams Games Tournament) on student learning motivation. Researchers conducted research at SDN Cangkring Turi Prambon. The type of research used is a quantitative approach to experimental methods with Pre Experimental design. The type used is One Group Pretest-Posttest Design. The subjects taken were 21 grade II students at SDN Cangkring Turi Prambon. TGT learning model (Teams Games Tournament) is used to find out the effect of the TGT learning model (Teams Games Tournament) on the learning motivation of class II students of SDN Cangkring Turi Prambon. The results of this study indicate that the analysis of the data obtained is the count of 20.80 and a table of 1.725. Thus count > table, namely 20.80> 1.725, there is the effect of the TGT model (Teams Games Tournament) on the learning motivation of class II students of SDN Cangkring Turi Prambon. While the results of the eta squared test obtained 0.955 ≥ 0.14 has the meaning of great influence.
The importance and morphobiology of the povlovnia tree
Authors: Zakirjan Tojiboyevich Bustonov,  , Mavlonjonovich Rakhimov Mansurbek
Published: August 2020

It is well known that the findings of scientists in the field of forestry, as well as the introduction of new technologies in production are of great importance. In particular, it is necessary to scientifically substantiate the normal growth and adaptation of new plant species. In addition, the role of trees in the prosperity of every person is unparalleled. This valuable tribute to treasure plays an important role in the economy of the economy, growing and increasing new types of trees and discovering their characteristics. Exemplary exotic trees in cities and villages, qualitative changes in timber supply and research by scientists in this field are clear evidence of the full support of innovation activities under the leadership of the President. Pavlovnia-Pavlovnia is part of the decorative tree species. There are 10 types of plants that are mainly grown in the east. Uzbekistan grows as an ornamental plant. The height of the neck is 12–20 meters, in the fall the normal edges of the leaf are scattered, and the bark opens until the leaf is released. The fruit is a large deciduous worm, the seeds are small, the light is soft. Povlovny made of pepper, roots and seeds.
Modern methods of preparing the children on Preschool educational organizations
Authors: A. Jabbarov  , Z.Qarshiyeva
Published: August 2020

This paper makes analyses of the modern methods of preparing the children on Preschool educational organizations. On these cases, different research points of the innovative research were mentioned on preschool educational organizations. It concludes with the different research analyses to make better investigations in further.
Efficacy of single high-molecular-weight versus triple low-molecular-weight hyaluronic acid intra-articular injection among knee osteoarthritis patients
Authors: Ebrahimpour Adel , Bahrami Mohammad Hasan , Raeissadat Seyed Ahmad , Cheraghi Mohsen , Rahimi-Dehgolan Shahram
Published: August 2020

Background: To compare intra-articular (IA) knee injections of a cross-linked high-molecular-weight hyaluronic acid (HMW-HA) with a linear low-molecular weight HA (LMW-HA) in terms of pain and functional improvement among knee osteoarthritis (OA) patients.Methods: In this single-blinded RCT, the patients were randomly divided into two groups for HA injections. The first group received an HMW-HA (Arthromac) injection, while the other received three weekly LMW-HA (Hyalgan) injections. Pain and function were assessed using the outcome measures including WOMAC, Lequesne and VAS indices, once prior to injection, as well as 2 and 6 months after injections.Results: A total of 90 patients were included. There was no significant difference in baseline characteristics including age and sex between the two groups. Our analysis showed that total WOMAC, Lequesne and VAS mean scores remarkably improved at both follow-up time-points compared to the baseline measurements (p<0.001). There was no significant superiority between the two therapeutic protocols according to our outcome measures at any time-point of follow-up. The only except was about the improvement in WOMAC stiffness subscale that was significantly higher in LMW-HA group compared to HMW-HA (p=0.021). Moreover, no significant difference was observed in minor complications and injection-induced pain scores between the two groups.Conclusion: This study proved that a single HMW-HA injection is as effective as multiple injections of LMW-HA counterparts in periods of 2 and 6 months follow-up.This study protocol was registered in Iranian database of RCTs (IRCT; www.irct.ir) with the trial registration number IRCT20130523013442N24 and registration date 2018-07-13.
Genomics-assisted prediction of salt and alkali tolerances and functional marker development in apple rootstocks
Authors: Liu Jing , Shen Fei , Xiao Yao , Fang Hongcheng , Qiu Changpeng , Li Wei , Wu Ting , Xu Xuefeng , Wang Yi , Zhang Xinzhong , Han Zhenhai
Published: August 2020

Background: Saline, alkaline, and saline-alkaline stress severely affect plant growth and development. The tolerance of plants to these stressors has long been important breeding objectives, especially for woody perennials like apple. The aims of this study were to identify quantitative trait loci (QTLs) and to develop genomics-assisted prediction models for salt, alkali, and salt-alkali tolerance in apple rootstock. Results: A total of 3,258 hybrids derived from the apple rootstock cultivars ‘Baleng Crab’ (Malus robusta Rehd., tolerant) × ‘M9’ (M. pumila Mill., sensitive) were used to identify 17, 13, and two QTLs for injury indices of salt, alkali, and salt–alkali stress via bulked segregant analysis. The genotype effects of single nucleotide polymorphism (SNP) markers designed on candidate genes in each QTL interval were estimated. The genomic predicted value of an individual hybrid was calculated by adding the sum of all marker genotype effects to the mean phenotype value of the population. The prediction accuracy was 0.6569, 0.6695, and 0.5834 for injury indices of salt, alkali, and salt–alkali stress, respectively. SNP182G on MdRGLG3, which changes a leucine to an arginine at the vWFA-domain, conferred tolerance to salt, alkali, and salt-alkali stress. SNP761A on MdKCAB, affecting the Kv_beta domain that cooperated with the linked allelic variation SNP11, contributed to salt, alkali, and salt–alkali tolerance in apple rootstock. Conclusions: The genomics-assisted prediction models can potentially be used in breeding saline, alkaline, and saline-alkaline tolerant apple rootstocks. The QTLs and the functional markers may provide insight for future studies into the genetic variation of plant abiotic stress tolerance.
Serum lithium test requesting across three UK regions: An evaluation of adherence to monitoring guidelines
Authors: Parfitt Ceri , Duff Christopher J , Scargill Jonathan , Green Lewis , Holland David , Heald Adrian H , Fryer Anthony
Published: August 2020

Background: Bipolar disorder is the fourth most common mental health condition, affecting ~1% of UK adults. Lithium is an effective treatment for prevention of relapse and hospital admission, and is widely recommended as a first-line treatment. We previously showed in other areas that laboratory testing patterns are variable with sub-optimal conformity to guidance. We therefore examined lithium results and requesting patterns relative to monitoring recommendations.Methods: Data on serum lithium levels and intervals between requests were extracted from Clinical Biochemistry laboratory information systems at the University Hospitals of North Midlands, Salford Royal Foundation Trust and Pennine Acute Hospitals from 2012-2018 (46,555 requests; 3,371 individuals). Data were examined with respect to region/source of request, age and sex.Results: Across all sites, lithium levels on many requests were outside the recommended UK therapeutic range (0.4-0.99 mmol/L); 19.2% below the range and 6.1% above the range (median [Li]: 0.60 mmol/L). A small percentage were found at the extremes (3.2% at <0.1mmol/L, 1.0% at ≥1.4mmol/L). Most requests were from general practice (56.3%) or mental health units (34.4%), though those in the toxic range (≥1.4 mmol/L) were more likely to be from secondary care (63.9%). For requesting intervals, there was a distinct peak at 12 weeks, consistent with guidance for those stabilised on lithium therapy. There was no peak at 6 months, as recommended for those aged <65 years on unchanging therapy, though re-test intervals in this age group were more likely to be longer. There was a peak at 0-7 days, reflecting those requiring closer monitoring (e.g. treatment initiation, toxicity). However, for those with initial lithium concentrations within the BNF range (0.4-0.99 mmol/L), 69.4% of tests were requested outside expected testing frequencies.Conclusions: Our data showed: (a) lithium levels are often maintained at the lower end of the recommended therapeutic range, (b) patterns of lithium results and testing frequency were comparable across three UK sites with differing models of care and, (c) re-test intervals demonstrate a noticeable peak at the recommended 3-monthly, but not at 6-monthly intervals. Many tests were repeated outside expected frequencies, indicating the need for measures to minimise inappropriate testing.
A Significant association between CXCL10 -1447 A>G and IL18 -607 C>A gene polymorphisms with Human T-cell lymphotropic virus type 1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM-TSP), a case-control report from city of Mashhad, Iran
Authors: Rafatpanah Houshang , Poursina Zohreh , Marzouni Hadi Zare , Atabaki Mahdi , Farid-Hosseini Reza , Tavakkol-Afshari Jalil , Mohammadi Mojgan
Published: August 2020

The authors have removed this preprint from Research Square.
A cross-sectional nationwide survey of congenital and infantile nephrotic syndrome in Japan
Authors: Hamasaki Yuko , Hamada Riku , Muramatsu Masaki , Matsumoto Shinsuke , Aya Kunihiko , Ishikura Kenji , Kaneko Tetsuji , Iijima Kazumoto
Published: August 2020

Background: Congenital nephrotic syndrome (CNS) and infantile nephrotic syndrome (INS) cause substantial morbidity and mortality. In Japan, there is a lack of knowledge regarding the characteristics of CNS and INS. This study aimed to clarify the characteristics of CNS and INS in Japan.Methods: This cross-sectional nationwide survey obtained data from 44 institutions in Japan managing 92 patients with CNS or INS, by means of two survey questionnaires sent by postal mail. Patients aged <16 years by 1 April 2015, with a diagnosis of CNS or INS, were included in this study. The primary outcome was end-stage kidney disease.Results: A total of 83 patients with CNS or INS were analyzed. The most frequent disease type was non-Finnish (60.2%); 33 patients (39.8%) had Finnish type. Among those with non-Finnish-type disease, 26 had no syndrome and 24 had a syndrome, of which the most frequent was Denys–Drash syndrome (70.8%). Patients with non-Finnish-type disease with syndrome showed the earliest progression to end-stage kidney disease compared with the other two groups, whereas patients with non-Finnish-type disease without syndrome progressed more slowly compared with the other two groups. In the Finnish-type group, the disease was diagnosed the earliest; a large placenta was reported more frequently; genetic testing was more frequently performed (93.8%); mental retardation was the most frequent extra-renal symptom (21.2%); and thrombosis and infection were more frequent compared with the other groups. Patients with non-Finnish-type disease with syndrome had a higher frequency of positive extra-renal symptoms (79.2%), the most common being urogenital symptoms (54.2%). Treatment with steroids and immunosuppressants was more frequent among patients with non-Finnish-type disease without syndrome. Two patients with non-Finnish-type disease without syndrome achieved complete remission. In all groups, unilateral nephrectomy was performed more often than bilateral nephrectomy and peritoneal dialysis was the most common renal replacement therapy.Conclusions: The present epidemiological survey sheds light on the characteristics of children with CNS and INS in Japan. A high proportion of patients underwent genetic examination, and patient management was in accord with current treatment recommendations and practices.Trial registration: Not applicable.
Parents' Multi-layered Expectations when Requesting an Autism Spectrum Disorder Assessment of their Young Child: an In-Depth Interview Study
Authors: Jacobs Delphine , Steyaert Jean , Dierickx Kris , Hens Kristien
Published: August 2020

Background Parents are valued stakeholders in research, clinical practice and policy development concerning autism spectrum disorder (ASD). However, little is known about what drives and moves parents besides their obvious worries and help request when they ask for a diagnostic ASD assessment of their child. Methods Seventeen Flemish parents of 11 young children participated in a longitudinal study consisting of three in-depth interviews before and after their child’s diagnostic ASD assessment. Data were analysed in Nvivo 11 according to the procedures of Interpretative Phenomenological Analysis. Results In this paper we report the results of the first series of interviews which were conducted after parents had asked for an ASD assessment of their young child, and before this assessment started. The pre-assessment experiences of the parents were dominated by the anticipation of various implications of an ASD diagnosis, comprising both positive and negative expectations. The theme of positive expectations consisted of two equally prominent subthemes: treatment-related implications but also expectations pertaining to their psychological and relational experiences. Conclusions This study suggests important issues for clinicians to bear in mind during a consultation with parents who request an ASD assessment of their young child. We argue that attending to and communicating about parents’ expectations prior to their child’s ASD assessment may help clinicians to better understand parents’ requests for help, and to address their needs more effectively.
Breastfeeding and acute lymphoblastic leukaemia: potential leukemogenesis in children in developing countries
Authors: Kakaje Ameer , Alhalabi Mohammad Marwan , Ghareeb Ayham , Karam Bahjat , Hamid Aya , Mansour Bassam , Zahra Bayan , Hamdan Othman
Published: August 2020

Background:Breastfeeding (BF) in infancy is associated with a decreased risk of acute lymphoblastic leukaemia (ALL). However, most of the studies were conducted in developed countries, neglecting developing countries where mothers might be exposed to different carcinogenic substances which could be transferred through breastmilk.Methods: This is a case-control study which was conducted in the major paediatric cancer centre in Syria. Data of case and control groups were obtained from the hospital’s records. Only patients with no hereditary or chromosomal syndrome and aged 4 years and younger were included. The case group included ALL patients and control group contained hospital patients who visited its various clinics. The patients were categorised into 3 groups depending on their feeding habits before the age of 6 months. Results:Our sample contained 70 patients in the case group with 42 (60%) being males and 82 patients in the control group with 52 (55.3%) being males. Sixty (85.7%) cases and 59 (72%) controls were exclusively breastfed. We found a statistically significant difference when comparing cases and controls in BF patterns (P<0.05) as cases were exclusively breastfed more frequently. Exclusive breastfeeding was found more frequently in the case group compared to other patterns of infancy feeding P=0.04 (OR, 2.339; CI, 1.025 -5.336). In case group, parents of a low educational level breastfed their children more frequently (P<0.05). Number of siblings was not associated with ALL or any of its variables. Furthermore, infancy feeding pattern correlation with gender, being born with no complications, consanguinity, CD10, FAB classification, ALL-subtype, risk, and family history were insignificant. Conclusion:There are certain practices among the Syrian people, especially among parents of a low educational level that has possibly exposed their children to carcinogenic substances which were possibly transferred through BF, causing this association between ALL and BF. We speculate certain substances and behaviours being responsible. However, BF had minor effects on the prognosis and subtype of ALL, and number of siblings had no effect on ALL.
Skin Rash Following Administration of Apalutamide in Japanese Patients with Advanced Prostate Cancer: An Integrated Analysis of the Phase 3 SPARTAN and TITAN Studies and a Phase 1 Open-Label Study
Authors: Uemura Hiroji , Koroki Yosuke , Iwaki Yuki , Imanaka Keiichiro , Kambara Takeshi , Lopez-Gitlitz Angela , Smith Andressa , Uemura Hirotsugu
Published: August 2020

Background: A higher incidence of apalutamide-related skin rash has been observed in Japanese patients with prostate cancer (PC). Methods: This integrated analysis of data of Japanese patients from 2 global Phase 3 studies, SPARTAN (NCT01946204; patients with non‑metastatic castration-resistant PC [nmCRPC]) and TITAN (NCT02489318; patients with metastatic castration-sensitive PC [mCSPC]), and the Phase 1 study 56021927PCR1008 (NCT02162836; patients with metastatic CRPC [mCRPC]), assessed clinical risk factors of apalutamide-related skin rash as well as the potential correlation with plasma exposure to apalutamide. Kaplan-Meier method was used for time-to-event analyses. Clinical risk factors for skin rash were assessed using odds ratio.Results: Data from 68 patients (SPARTAN: n=34, TITAN: n=28, 56021927PCR1008: n=6) receiving apalutamide 240 mg orally once-daily were analyzed. Rash (13 [19.1%]) and maculo-papular rash (11 [16.2%]) were the most frequently reported skin rash. All Grade and Grade 3 skin rash occurred in 35 (51.5%) and 10 (14.7%) patients, respectively. Most (85.7%) skin rash occurred within 4 months of apalutamide initiation and resolved in a median time of 1 month following the use of antihistamines, topical or systemic corticosteroids, with/without apalutamide dose interruptions/reductions. Median time-to-remission of first incidence of rash and maximum grade incidence of rash were 1.0 month (IQR: 0.36-1.81) and 1.0 month (IQR: 0.30-2.43), respectively. No significant clinical risk factors for the incidence of skin rash were observed. Areas under the curve (0-24 hours) (AUC0-24, ss) at steady‑state of plasma apalutamide concentration were numerically slightly higher in patients with skin rash than those without.Conclusions: No clinical risk factors for rash could be detected. There is a potential correlation between incidence of skin rash and plasma exposure to apalutamide. In general, apalutamide‑related skin rash is easily managed, with appropriate treatment with or without dose adjustment. Trial Registration: Retrospective pooled analysis of NCT01946204, NCT02489318, and NCT02162836
Epidemiologic, Clinical, and Laboratory Findings of the COVID-19 in the current pandemic: Systematic Review and Meta-analysis
Authors: Xie Yewei , Wang Zaisheng , Liao Huipeng , Marley Gifty , Wu Dan , Tang Weiming
Published: August 2020

Background: The COVID-19 pandemic has affected the world deeply, with more than 3,000,000 people infected and nearly 200,000 deaths. This review aimed to summarize the epidemiologic traits, clinical spectrum, CT results and laboratory findings of the COVID-19 pandemic.Methods: We scoped for relevant literatures published during 1st Dec 2019 to 23rd Apr 2020 based on four databases using English and Chinese languages. We reviewed and analyzed the relevant clinic outcomes of COVID-19.Results: The COVID-19 pandemic was found to have a higher transmission rate compared to SARS and MERS and involved 4 stages of evolution. The basic reproduction number (R0) is 3.32 (95% CI:3.24-3.39), the incubation period was 5.24 days (95% CI:3.97-6.50, 5 studies) on average, and the average time for symptoms onset varied by countries. Common clinical spectrums identified included fever (38.1-39.0℃), cough and fatigue, with Acute Respiratory Distress Syndrome (ARDS) being the most common complication reported. Body temperatures above 39.0 ℃, dyspnea, and anorexia were more common symptoms in severe patients. Aged over 60 years old, having co-morbidities, and developing complications were the commonest high-risk factors associated with severe conditions. Leucopenia and lymphopenia were the most common signs of infection while liver and kidney damage were rare but may cause bad outcomes for patients. The bilateral, multifocal Ground-Glass Opacification (GGO) on peripheral, and the consolidative pulmonary opacity were the most frequent CT results and the tendency of mortality rates differed by region.Conclusions: We provided a bird’s-eye view of the COVID-19 during the current pandemic, which will help better understanding the key traits of the disease. The findings could be used for disease’s future research, control and prevention.
Molecular characterization of Plasmodium falciparum DNA-3-methyladenine glycosylase
Authors: Pinthong Nattapon , Limudomporn Paviga , Vasuvat Jitlada , Adisakwattana Poom , Rattaprasert Pongruj , Chavalitshewinkoon-Petmitr Porntip
Published: August 2020

Background The emergence of artemisinin-resistant malaria parasites highlights the need for novel drugs and their targets. Alkylation of purine bases can hinder DNA replication and if unresolved would eventually result in cell death. DNA-3-methyladenine glycosylase (MAG) is responsible for the repair of those alkylated bases. Plasmodium falciparum (Pf)MAG was characterized for its potential for development as an anti-malarial candidate.Methods Native PfMAG from crude extract of chloroquine- and pyrimethamine-resistant P. falciparum K1 strain was partially purified using three chromatographic procedures. From bio-informatics analysis, primers were designed for amplification, insertion into pBAD202/D-TOPO and heterologous expression in Escherichia coli of recombinant PfMAG. Functional and biochemical properties of the recombinant enzyme were characterized. Results PfMAG activity was most prominent in parasite schizont stages, with a specific activity of 147 U/mg (partially purified) protein. K1 PfMAG contained an insertion of AAT (coding for asparagine) compared to 3D7 strain and 16% similarity to the human enzyme. Recombinant PfMAG (74 kDa) was twice as large as the human enzyme, preferred double-stranded DNA substrate, and demonstrated glycosylase activity over a pH range of 4-9, optimal salt concentration of 100-200 mM NaCl but reduced activity at 250 mM NaCl, no requirement for divalent cations, which were inhibitory in a dose-dependent manner.Conclusio PfMAG activity increased with parasite development being highest in the schizont stages. K1 PfMAG contained an indel AAT (asparagine) not present in 3D7 strain and the native enzyme was twice as large as the human enzyme. Recombinant PfMAG had a wide range of optimal pH activity, and was inhibited at high (250 mM) NaCl concentration as well as by divalent cations. The properties of PfMAG provide basic data that should be of assistance in developing anti-malarials against this potential parasite target.
Lead Time Bias as a Factor in Mammography Detected Invasive Breast Cancer Survival in an Institutional Cohort
Authors: Kaplan Henry G. , Malmgren Judith , Atwood Mary K.
Published: August 2020

Background: Lead time, the interval between screen detection and when a disease would have become clinically evident, has been cited to explain longer survival times in mammography detected breast cancer cases (BC). Methods: An institutional retrospective cohort study of BC outcomes related to detection method (mammography (MamD) vs. patient (PtD)). Cases were first primary invasive stage I-III BC, age 40-74 years (n = 6603), 1999-2016. Survival time was divided into 1) distant disease-free interval (DDFI) and 2) distant disease-specific survival (DDSS) as two separate time interval outcomes. We measured statistical association between detection method and diagnostic, treatment and outcome variables using bivariate comparisons, Cox proportional hazards analyses and mean comparisons. Outcomes were distant recurrence (n=422), DDFI and DDSS. Results: 39% of cases were PtD (n = 2566) and 61% were MamD (n = 4037). MamD cases had a higher percentage of Stage I tumors [MamD 69% stage I vs. PtD 31%, p<.001]. Rate of distant recurrence was 11% among PtD BC cases (n=289) vs. 3% of MamD (n=133) (p<.001). Order of factor entry into the distant recurrence time interval (DDFI) model was 1) TNM stage (p<.001), 2) HR/HER2 status (p<.001), 3) histologic grade (p=.005) and 4) detection method (p<.001). Unadjusted PtD DDFI mean time was 4.34 years and MamD 5.52 years (p<.001) however when stratified by stage, the most significant factor relative to distant recurrence, there was no significant difference between PtD and MamD BC. Distant disease specific survival time did not differ by detection method.Conclusion: We observed breast cancer survival differential lead time to be a function of stage at diagnosis and tumor characteristics with marginal contribution of detection method. Patient and mammography detected breast cancer time to distant recurrence did not differ stratified by stage indicating survival difference is more likely related to early diagnosis than lead time bias. Lead time bias associated with breast cancer detection method appears to have marginal influence on survival in the current diagnostic and treatment era.
Pneumothorax in patients with idiopathic pulmonary fibrosis: A real-world experience
Authors: Yamazaki Ryo , Nishiyama Osamu , Gose Kyuya , Saeki Sho , Sano Hiroyuki , Iwanaga Takashi , Tohda Yuji
Published: August 2020

Background: Some patients with idiopathic pulmonary fibrosis (IPF) develop pneumothorax. However, the characteristics of pneumothorax in patients with IPF have not been elucidated. The purpose of this study was to clarify the clinical course, actual management, and treatment outcomes of pneumothorax in patients with IPF.Methods: Consecutive patients with IPF who were admitted for pneumothorax between January 2008 and December 2018 were included. The success rates of treatment for pneumothorax, hospital mortality, and recurrence rate after discharge were examined.Results: During the study period, 36 patients with IPF were admitted with pneumothorax a total of 59 times. During the first admission, 15 patients (41.7%) did not receive chest tube drainage, but 21 (58.3%) did. Of the 21 patients, 8 (38.1%) received additional therapy after chest drainage. The respective treatment success rates were 86.6% and 66.7% in patients who underwent observation only vs chest tube drainage. The respective hospital mortality rates were 13.3% and 38.0%. The total pneumothorax recurrence rate after hospital discharge was 53.8% (n = 14).Conclusions: Pneumothorax in patients with IPF was difficult to treat successfully, had a relatively poor prognosis, and showed a high recurrence rate.
Health status, lifestyle habits, and perceived social support in long-term cancer survivors: a cross-sectional study
Authors: León-Salas Beatriz , Zabaleta-del-Olmo Edurne , LLobera Joan , Bolíbar-Ribas Bonaventura , López-Jiménez Tomas , Casajuana-Closas Marc , Cantó Magdalena Esteva
Published: August 2020

Objective: To compare the presence of comorbidities and self-perceived health and social support between long-term cancer survivors and people without a history of cancer from a clinical trial examining the effects of a multiple risk behavior intervention.Results: Of the 4259 people studied, 190 (4.46%) were cancer survivors. They had a mean ± SD age of 62.8±7 years vs. 58.7±8 years (P<0.01) for non-cancer people and were more likely to be on long-term sick leave (11.9% vs. 3.5%, P<0.001). No differences were observed for smoking, adherence to the Mediterranean diet, physical activity, obesity, or social support. Cancer survivors were more likely to have worse self-perceived health (OR 1.82; 95% CI 1.02–2.75), more comorbidities (OR 1.68; 95% CI 1.18–2.39), COPD (OR 2.17; 95% CI 1.25–3.78), and depression (OR 1.65; 95% CI 1.06–2.57). Older age and worse self-perceived health were independent predictors of survivorship in the adjusted analysis.
MiR-4310 induced by SP1 targets PTEN to promote glioma progression
Authors: Zhiyong Wu , Jie Luo , Tengyue Huang , Renhui Yi , Shengfeng Ding , Cheng Xie , An'qi Xu , Yu Zeng , Xizhao Wang , Ye Song , Hao Long
Published: August 2020

Background: miRNAs have been reported to be involved in multiple biological processes of gliomas. Here, we aimed to analyze miR-4310 and its correlation genes involved in the tumor progression of human glioma.
Methods: miR-4310 expression levels were examined in glioma and non-tumor brain (NB) tissues. The molecular mechanisms of miR-4310 expression and its effects on cell proliferation, migration, and invasion were explored by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) , Transwell chamber, Boyden chamber, and western blot analyses, as well as in vivo tumorigenesis in nude mice. The relationships among miR-4310, SP1, and phosphatase and tensin homolog (PTEN) were explored by chromatin immunoprecipitation (ChIP), agarose gel electrophoresis, electrophoresis mobility shift (EMSA), and dual luciferase reporter gene assays.
Results: miR-4310 expression was upregulated in glioma tissues compared to NB. Overexpressed miR-4310 promoted glioma cell proliferation, migration, and invasion in vitro and tumorigenesis in vivo . Inhibition of miR-4310 was sufficient to reverse these results. Mechanistic analyses revealed that miR-4310 promoted glioma progression through the PI3K/AKT pathway by targeting PTEN. Additionally, SP1 induced the expression of miR-4310 by binding to its promoter region.
Conclusion: miR-4310 promotes the progression of glioma by targeting PTEN and activating the PI3K/AKT pathway meanwhile the expression of miR-4310 is induced by SP1.
Wastewater to Ecological dyeing process and bioactive compounds resources: case study of Dittrichia graveolens hydrodistillation aqueous residue
Authors: Gharred Nawres , Baaka Noureddine , Bettache Nadir , Hamdi Assia , Dbeibia Amal , Dhaouadi Hatem , Morere Alain , Menut Chantal , Dridi-Dhaouadi Sonia
Published: August 2020

The release of aqueous residues generated by the extraction process of essential oils presents a real risk of environmental pollution. This work aims to reduce this risk and produce value-added materials. The aqueous residue of Dittrichia graveolens (D. graveolens) hydrodistillation has been reused in two valorization ways: 1/ in the ecological dyeing. 2/ in biological field. First, a phytochemical study of the aqueous residue was carried out by determining the ployphenols and flavonoids content and high performance liquid chromatography (HPLC) analysis. Second, the eco-dyeing process with the aqueous residue was performed on the polyamide fabric, the process was optimized by the surface response methodology using Minitab software and was evaluated by the fastness tests for the optimal conditions. Third, the aqueous residue was assessed for its biological activities. Promising coloring power and biological potential of the aqueous residue showed that this last could be an important source for developing environmentally friendly natural dyes and bioactive products.
Measurement of Postpartum Blood Loss Using a New Two - Set Liquid Collection Bag for Vaginal Delivery: A Prospective, Randomized, Case Control Study
Authors: Wang Fang , Lu Nanjia , Weng Xiaofeng , Tian Yanping , Sun Shiwen , Li Baohua
Published: August 2020

Background Postpartum hemorrhage (PPH) is a major obstetric complication, and the real-time measurement of blood loss is important in the management and treatment of PPH. We designed a new two-set liquid collection bag (TSLCB) for measuring postpartum blood loss in vaginal delivery. The aim of this study was to evaluate the effectiveness of the TSLCB in separating the blood from the amniotic fluid during vaginal delivery and in determining the accuracy of the measured postpartum blood loss.Methods A prospective, randomized, case control study was conducted in the Women’s Hospital, Zhejiang University School of Medicine, from March 2018 to April 2018. Sixty single pregnant women with spontaneous labor at 37–41 weeks without maternal complications were randomly divided into the experimental and control groups. The TSLCB was used to evaluate separately the amount of blood and amniotic fluid. For the control group, visual estimation and traditional plastic blood-collecting consumables were used to estimate the amount of postpartum blood loss. The measured blood loss between the two groups was compared, and the association of the measured blood loss with various clinical lab indices and vital signs was investigated. Results The TSLCB (the experimental group) improved the detection of the measured blood loss compared with visual estimation and the traditional method (the control group) (p < 0.05). In the experimental group, correlation analysis showed that the measured blood loss at delivery and within 24 h of delivery was significantly associated with the decreased hemoglobin level, red blood cell count, and hematocrit level of patients (r = -0.574, -0.455, -0.437; r = 0.-595, -0.368, -0.374; p < 0.05). In the control group, only the measured blood loss within 24 h of delivery was associated with the decreased hemoglobin level (r = -0.395, p < 0.05). No blood transfusion and plasma expanders were required in the treatment of PPH for both groups.Conclusions The TSLCB can be used to accurately measure the postpartum blood loss in vaginal delivery by medical personnel.Trial registration: This trial was registered with Chinese Clinical Trial Registry (ChiCTR): ChiCTR-IOR-17012453, 23 August 2017.
Compositional and Drug-Resistance Profiling of Pathogens in Patients with Severe Acute Pancreatitis
Authors: Fan Ning , Hu Yong , Liu Shengjie , Zhao Guang , Sun Lanju , Li Chunyan , Zhao Xin , Li Yanning , Wang Jianhua , Cui Yunfeng
Published: August 2020

Background: Infection is one of the important causes of death in patients with severe acute pancreatitis (SAP), but the bacterial spectrum and antibiotic resistance are constantly changing. Making good use of antibiotics and controlling multi-drug-resistant (MDR) bacterial infections are important steps in improving the cure rate of SAP.Methods: A total of 171 patients were enrolled in this study; the abdominal drainage fluid, sputum, blood, bile, deep venous catheter and urine of patients were cultured, identified and tested for resistance with a blood culture apparatus and microbiological analyzer. The associated results and hospitalization data were analyzed. Results: A total of 461 strains of pathogenic bacteria were detected, including 223 (48.4%) gram-negative bacterial strains, 190 (41.2%) gram-positive bacterial strains and 48 (10.4%) fungal strains. The detection rates of resistance in gram-negative and gram-positive bacterial strains were 48.0% (107/223) and 25.3% (48/190), respectively. There were significant differences between the MDR group and the non-MDR group for the factors of precautionary antibiotic use, kinds of antibiotics used, receipt of carbapenem, tracheal intubation, hemofiltration and number of hospitalization days in the intensive care unit. Unconditional logistic regression revealed 2 risk factors for MDR bacterial infection. Conclusions: Our results illustrate that gram-negative bacteria were the most common pathogens in SAP infection, and the proportion of gram-positive bacteria increased notably. The rate of antibiotic resistance was higher than previously reported. Unconditional logistic regression analysis showed that using more types of antibiotics and the number of hospitalization days in the ICU were the risk factors associated with MDR bacterial infection.
Effects of Resuming Training Using Yoga on Physical Functions and Fitness of Taekwondo Athletes After High-intensity Training
Authors: Liu Feng , Hou Gaixia , Liang Cheng
Published: August 2020

Objective: This study aimed to analyze the effects of resuming training using yoga on the physical functions and fitness of Taekwondo athletes after high-intensity training.Method: A total of 50 Taekwondo athletes from this college were randomly divided into 2 groups. 25 athletes are in the control group, and they massage their muscles after high-intensity training to help recovery. Meanwhile, 25 athletes are in observation groups, and they practice yoga after high-intensity training for resuming training. After 8 weeks, the physical functions and fitness of the two groups of athletes were compared.Result: There was no statistically significant difference between the observation group and the control group before starting high-intensity training from 1st week to 8th week (P<0.05). From the 4th week to the 8th week after high-intensity training, the observation group's heart rate, heart rate after resuming training and subjective physical sensation degree scores were lower than the control group (P<0.05). After 8 weeks of resuming training in the observation group, hemoglobin was higher than the control group, blood urea nitrogen and creatine kinase was lower than the control group (P<0.05). The observation group's flexion test results of the sitting position after 4th week and 8th week of resuming training were higher than those of the control group (P<0.05).Conclusion: The use of yoga for resuming training after high-intensity training can improve the physical function and fitness of Taekwondo athletes, improve the flexibility of athletes and promote their professional skills.
Inhibition of pyruvate dehydrogenase kinase influence microbiota and metabolomic profile in pancreatic cancer xenograft mice
Authors: Adamberg Kaarel , Vilu Raivo , Pazienza Valerio
Published: August 2020

Objective
Despite recent advances in treatment options, pancreatic cancer remains the most deadly major cancer. Targeting metabolism represents an emerging anti-cancer strategy.
Results
Metagenomic 16S analysis was employed to explore the effect of Dichloroacetate (DCA) on the composition of the fecal microbiota and metabolomic profile was assessed on in vivo pancreatic cancer mouse xenograft model. Pancreatic cancer xenograft mice displayed a shift of microbiota’ profile as compared to control mice without DCA treatment and a significant decrease of the purine bases inosine xanthine together with their metabolically-related compound hypoxanthine were observed in the DCA treated group as compared to the control group. Two aminoacids methionine and aspartic acid resulted decreased and increased respectively. DCA affects tumor environment and studies are needed in order to understand whether DCA supplementation could be supportive as synergistic approach to enhance the efficacy of existing cancer treatments in pancreatic cancer patients.
Evaluation of the effects of an interdisciplinary lifestyle and health program for adolescents and its benefits for maintaining health.
Authors: Schuster Anja , Schwenoha Karin , Oberkofler Edith , Lirk Gerald , Ardelt-Gattinger Elisabeth , Weghuber Daniel , Ring-Dimitriou Susanne , Freudenthaler Thomas , Oostingh Gertie J. , Bogner Barbara
Published: August 2020

The authors have withdrawn this preprint due to erroneous posting.
The Evaluation of Degeneration of Posterior Cruciate Ligament Using CT Hounsfield Unit in Knee Osteoarthritis
Authors: Sumida Yoshikazu , Nakasa Tomoyuki , Ishikawa Masakazu , Nakamae Atsuo , Adachi Nobuo
Published: August 2020

Background The degeneration of posterior cruciate ligament (PCL) is often seen in knee osteoarthritis (OA), however there is no established method for its evaluation. The purpose of this study is to investigate whether Hounsfield unit (HU) using CT (computed tomography) could be a useful scale to evaluate the degeneration of PCL in knee OA.Methods Knee OA treated with total knee arthroplasty (21 patients, 21 knees) and non-osteoarthritic knees (21 patients, 21 knees) were prospectively studied. All PCLs in the knees were analyzed by CT scan. PCL in sagittal section was divided into three regions: proximal, middle and distal portions. The HU value of PCL at each area was measured. In osteoarthritic knees, tissues from PCL were collected and histologically graded.Results The HU value in OA and non-OA was 70.7 and 86.5 HU (p < 0.05) at proximal region, 75.7 HU and 86.6 (p < 0.05) at central region and 82.3 and 88.1 HU (p > 0.05) at distal region, respectively. The degeneration of PCL was graded as follows; mild: 1 case, moderate: 3 cases and severe: 17 cases at proximal portion and mild: 16 cases, moderate: 4 cases and severe: 1 case at distal portion. The HU value was 84.5 HU for mild, 72.1 HU for moderate and 70.6 HU for severe (mild versus moderate: p < 0.05, mild versus severe: p < 0.05, moderate versus severe: p > 0.05).Conclusions In knee OA, lower HU value in PCL indicates progression of degeneration. The CT HU value could be a useful measurement to predict the grade of degeneration of PCL.
Development and Psychometric Properties of a Compassionate Care Questionnaire for Nurses
Authors: Tehranineshat Banafsheh , Rakhshan Mahnaz , Torabizadeh Camellia , Fararouei Mohammad , Gillespie Mark
Published: August 2020

Background: Compassionate care is emphasized within professional ethics codes for nursing and is a key indicator of care quality. The purpose of this study was to design and assess the psychometric properties of a compassionate care instrument for nurses.Methods: This methodological study was carried out in two qualitative and quantitative phases from February 2016 to October 2018. The first phase was composed of a qualitative study using a content analysis approach to explain the concept of compassionate care through interviewing nurses, patients and family caregivers. The original draft of the questionnaire was developed using qualitative findings and a subsequent review of literature. In the second phase, the psychometric properties of the questionnaire were assessed for validity and reliability. Data analysis was performed using descriptive and inferential statistics via SPSS v.16 software.Results: According to the results of the qualitative phase and review of literature, 80 items were extracted. In the quantitative phase, face and content validity led to retaining 40 items. In construct validity, 28 items with a factor load above 0.4 were retained. Convergent validity showed a moderate correlation coefficient between the questionnaire and the nurses' caring behaviors tool (r = 0.67, P = 0.01). Reliability of the 28-item questionnaire using the calculation of the Cronbach's alpha coefficient and the intra-class correlation coefficient were reported as 0.91 and 0.94 for the whole questionnaire, respectively.Conclusion: The questionnaire had an appropriate validity and reliability for measuring nurses' compassionate care. Therefore, the instrument can be used to measure and report the quality of nursing care.
Innovative Strategies For Providing Menstruation-Supportive Water, Sanitation And Hygiene (Wash) Facilities: Learning From Refugee Camps In Cox’s Bazar, Bangladesh
Authors: Schmitt Margaret L , Wood Olivia R. , Clatworthy David , Rashid Sabina Faiz , Sommer Marni
Published: August 2020

The authors have withdrawn this preprint due to author disagreement.
Identification of Plant Leaf Phosphorus Content at Different Growth Stages Based on Hyperspectral Reflectance
Authors: Siedliska Anna , Baranowski Piotr , Pastuszka-Woźniak Joanna , Zubik Monika , Krzyszczak Jaromir
Published: August 2020

Background: Modern agriculture strives to sustainably manage fertilizer for both economic and environmental reasons. The monitoring of any nutritional (phosphorus, nitrogen, potassium) deficiency in growing plants is a challenge for precision farming technology. A study was carried out on three species of popular crops, celery (Apium graveolens L., cv. Neon), sugar beet (Beta vulgaris L., cv. Tapir) and strawberry (Fragaria × ananassa Duchesne, cv. Honeoye), fertilized with four different doses of phosphorus (P) to deliver data for non-invasive detection of P content. Results: Data obtained via biochemical analysis of the chlorophyll and carotenoid contents in plant material showed that the strongest effect of P availability for plants was in the diverse total chlorophyll content in sugar beet and celery compared to that in strawberry, in which P affects a variety of carotenoid contents in leaves. The measurements performed using hyperspectral imaging, obtained in several different stages of plant development, were applied in a supervised classification experiment. A machine learning algorithm (Backpropagation Neural Network, Random Forest, Naive Bayes and Support Vector Machine) was developed to classify plants from four variants of P fertilization. The lowest prediction accuracy was obtained for the earliest measured stage of plant development. Statistical analyses showed correlations between leaf biochemical constituents, phosphorus fertilization and the mass of the leaf/roots of the plants. Conclusions: Obtained results demonstrate that hyperspectral imaging combined with artificial intelligence methods has potential for non-invasive detection of non-homogenous phosphorus fertilization on crop levels.