bluuebunny/crossref_metadata_2025 huggingface dataset:
Medical record documentation of cancer patients after an integrated engagement plan.
Authors: Bariani Giovanni M. , Macedo Caroline , Da Silva Mariana , Yamashita Karine , Ruiz Amanda , Pedroso Aline , Ledo Carla Bernardes , Oliveira Fabrícia de Santi Silva de , Vieira Silvia de Lima , Luciani Camila , Katz Artur
Published: October 2019

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Background: Complete and accurate medical record (MR) documentation is essential to quality of cancer patient care, whose complex health and social needs should be addressed during medical consultation. We aimed to evaluate the MR compliance before and after an engagement plan (EP) and an education meeting (EM) for oncologists. Methods: An integrated EP was designed to improve medical notes in a Brazilian cancer center. Firstly, a pool of 160 selected MR of patients with prevalent neoplasms was reviewed to identify frequently missed components. Based on this result, a set of MR documentation standards was developed and presented in an EM for oncologists. To verify its effect, a cross-sectional analysis was performed using 25 standard elements collected from randomized MR before and after the EM such as pathology report, cancer stage, medical history, treatment plan, patient comprehension, and initial psychological assessment. It was given particular emphasis to psychological assessment during the EM as a low documentation of it was identified after the first MR review. The variation of the proportions pre- and post-EM was assessed using the chi-square test. Results: A total of 850 elements were collected from 34 patients’ MR two months pre-EM and 950 elements of 38 patients’ MR two weeks after. Of these patients, pre-EM 18 were under intravenous (IV) therapy and 16 under oral antineoplastic therapy and, post-EM, 14 and 24 patients were under IV and oral therapy, respectively. Pre-EM, MR compliance of patients under oral therapy was 68% and for patients under IV therapy 78% (P = 0.0013). Post-EM, the difference between MR compliance of patients under oral and IV therapy was 6% (82% vs. 88%, P = 0.0167). Overall MR compliance pre-EM was 73% and post-EM 84% (P < 0.0001). Psychological assessment pre- and post-EM were 9% and 50% (P = 0.0002), respectively. Conclusions: Patients under IV therapy have a more accurate MR documentation than patients under oral therapy. Overall compliance of MR documentation was significantly improved after an EM, a part of an integrated EP. Psychological assessment documentation has not only improved, but it is expected that more attention has been given to this valuation by oncologists.
Reducing emergency department utilization by improving patient access to their oncology care team.
Authors: Philip Tony , Gleason Karen , Nekola Claire , Tucker Todd , Paul Valadez Jenny , Prasad-Goyal Shreya , Meisels Samantha , Bowman Ronda Marie , Kaufman Laura
Published: October 2019

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Background: At Monter Cancer Center, we observed that when patients on active intravenous chemotherapy presented to our local ED about 70% arrived during the hours of 8am and 6pm. ED utilization by active chemotherapy patients results in cancer care by providers not familiar with their disease or treatment, increased costs, poor patient experience and potential treatment delays. Our goal was to create 20% reduction in daytime ED utilization, compared to Q4 2018, by patients that received intravenous chemotherapy within 30 days of their ED visit. Methods: Through the ASCO Quality Training program, a multidisciplinary team of frontline staff was formed to create a Process map, Cause and effect diagram and Priority Matrix to develop solutions. Our first PDSA created a simplified criteria to help office secretaries triage urgent and non-urgent calls to providers. This allowed patients with urgent issues to speak to their care team on first call rather than await a callback. In our second PDSA, our treatment room nurses emphasized to patients on their treatment discharge to contact their care team first for symptom management rather than going to the ED. Results: Compared to our baseline, we have seen a 33% decrease in ED utilization by re-educating patients to call us first for symptoms and providing a clear tool to help secretaries triage calls to the care team. Conclusions: Our study shows improving patient access to their oncology care teams can decrease ED utilization, increase cancer center utilization while improving patient safety across multiple disease types.
Using a geographic and interdisciplinary strategy to improve patient care outcomes.
Authors: Philip Tony , Karlin-Zysman Corey , Rimar Alex , Liberman Tara , Cardoza Donna , Carleton Jane E. , Devoe Craig E.
Published: October 2019

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Background: Long Island Jewish Medical Center at Northwell Health is an urban/suburban academic tertiary care hospital located across the street from the Northwell Health Cancer Institute. The Division of Hospital Medicine partnered with Hematology/Oncology and Palliative Care to co-manage inpatient oncology patients on a geographic unit. The goal was to improve patient care through co-ownership and co-accountability of cancer patients in conjunction with a unit-based collaboration with Nursing, Pharmacy, Social Work, Case Management and Physical Therapy. Methods: A unit-based, interdisciplinary care team was formed consisting of Medical Oncologists, Hospitalists, Palliative Care specialists, Radiation Oncologists, as well as unit based and specialty trained nurses, social workers and advanced care practitioners. The team meets Monday thru Friday during interdisciplinary rounds to collaboratively discuss the care plans of each patient. We recently added a hospital-based medical oncologist to support greater continuity and communication. Results: Since full implementation including improvements in patient cohorting, the oncology care model has resulted in a 20% reduction in Medicare readmissions, a significant reduction in CAUTIs and CLABSIs, a 50% reduction in C.diff, a decreased CMI-adjusted length of stay and an improvement in pain management HCAHP scores, despite a 10% increase in CMI. An interdisciplinary approach has also improved documentation of goals of care discussion from 6% to 40-58%, furthering the idea of providing a unified medical voice to a vulnerable population. Conclusions: The oncology care model highlights that implementing multidisciplinary rounding, co-management and population-based geography can deliver a higher quality and more efficient level of care even in the face of higher patient acuity.
Nonthyroidal Illness Syndrome Across the Ages
Authors: Langouche Lies , Jacobs An , Van den Berghe Greet
Published: October 2019

In conditions of acute illness, patients present with reduced plasma T3 concentrations without a concomitant rise in TSH. In contrast, plasma concentrations of the inactive hormone rT3 increase, whereas plasma concentrations of T4 remain low-normal. This constellation of changes, referred to as nonthyroidal illness syndrome (NTIS), is present across all ages, from preterm neonates and over-term critically ill infants and children to critically ill adults. Although the severity of illness strongly correlates with the severity of the NTIS phenotype, the causality of this association remains debated, and pathophysiological mechanisms remain incompletely understood. In the acute phase of illness, NTIS appears to be caused predominantly by an increased peripheral inactivation of thyroid hormones, in which reduced nutritional intake plays a role. Current evidence suggests that these acute peripheral changes are part of a beneficial adaptation of the body to reduce expenditure of energy and to activate the innate immune response, which is important for survival. In contrast, in more severely ill and prolonged critically ill patients, an additional central suppression of the thyroid hormone axis alters and further aggravates the NTIS phenotype. Recent studies suggest that this central suppression may not be adaptive. Whether treatment of this central component of NTIS in prolonged critically ill patients, with the use of hypothalamic releasing factors, improves outcome remains to be investigated in large randomized control trials.
“An Observance of Silence to the Events”
Authors: Johnson Shelby
Published: October 2019

Juliet Granville, the protagonist of Frances Burney’s novel The Wanderer (1814), enters the novel fleeing the French Revolution and disguised in blackface. This article argues that Juliet’s act of racial counterfeiting implicitly gestures toward the Haitian Revolution without naming that historical touchstone and emblematizes a theory of trace histories that Burney articulates in the novel’s dedication. There, she sketches an agonistic vision of history through what she calls “traces,” where events “though already historical, have left traces” that have been “handed down . . . from generation to generation” and tarry in the present. Burney frames the trace as an afterlife of an event that cannot be quite integrated into the broader scope of “history” as such but which leaves behind profound formal remainders. Burney’s dedication thus theorizes how to read Romantic-era novels for those fragments of form, and Juliet’s disguise replots erasures of Caribbean history as a problem of reading.
First Words, Last Words
Authors: Haslanger Andrea
Published: October 2019

This short piece reads two of Phillis Wheatley’s elegies to children to reflect on how they represent the dead as speaking rather than silent. It considers how the deceased’s speech invokes different categories of the child, overlaying political and theological ideas about children’s vulnerability and potential power.
Queen Charlotte’s 1789 Account Book
Authors: Kassler Michael
Published: October 2019

Queen Charlotte’s account book for part of 1789 is transcribed and annotated for the first time from her manuscript in the Royal Archives. It records payments made during the royal family’s seaside vacation in Wey-mouth and payments made after their return to Windsor. Almost all the payees mentioned in the book are identified.
“A Boy Inside It”
Authors: Moore Melina Alice
Published: October 2019

This essay explores Ann Bannon’s lesbian pulp series “The Beebo Brinker Chronicles” through the lens of trans studies, placing her eponymous hero in conversation with the inversion rhetoric of sexological discourse and the transgender pulp novels that circulated alongside Bannon’s texts in the 1950s and 1960s. Despite the prominence of Beebo’s masculine identification, and the fact that Bannon draws heavily from Radclyffe Hall’s The Well of Loneliness—now widely read as a transgender text—Beebo has yet to be read as a character that resonates within both the trans and the lesbian literary canons. Revisioning Beebo as a transmasculine character transforms our understanding of an unfolding trans-gender literary tradition, offering a bridge between Hall’s Stephen Gordon and later twentieth-century articulations of transmasculine identity and embodiment. Further, the essay suggests that Bannon’s series provides a vital intervention in the “case study” framing that dominated both transgender pulp novels and The Well by offering a vision of trans experience that, presented in the romance genre, exists outside medical authority. If we broaden the context for studying Beebo to include other contemporary trans literary genealogies, Bannon’s work becomes integral to understanding the pulp genre’s treatment of transgender themes and the reach of transgender plots and possibilities at midcentury.
The C. elegans cysteine-string protein homologue, DNJ-14, is dispensable for neuromuscular junction maintenance across ageing
Authors: Mulcahy Ben , Ibbett Paul , Holden-Dye Lindy , O'Connor Vincent
Published: October 2019

Maintenance of synaptic function across ageing is vital in sustaining cognitive function. Synaptic dysfunction is a key part of the pathophysiology of a number of neurodegenerative diseases. The synaptic co-chaperone, cysteine-string protein (CSP), is important for synaptic maintenance and function in Drosophila, mice, and humans, and disruption of CSP results in synaptic degeneration. We sought to characterize synaptic ageing in C. elegans upon genetic disruption of CSP. To do this we focused on the worms’ neuromuscular junctions which are the best characterized synapse. CSP mutant worms did not display reduced lifespan or any neuromuscular-dependent behavioural deficits across ageing. Pharmacological interrogation of the neuromuscular synapse of CSP mutant animals showed no sign of synaptic dysfunction even at advanced age. Lastly, patch clamp analysis of neuromuscular transmission across ageing in wild-type and CSP mutant animals revealed no obvious CSP-dependent deficits. Electrophysiological mPSC analysis reinforced pharmacological observations that the C. elegans neuromuscular synapse increases in strength during early ageing and remains relatively intact in old, immotile worms. Taken together this study shows that surprisingly, despite disruption of CSP in other animals having severe synaptic phenotypes, CSP does not seem to be important for maintenance of the neuromuscular junction across ageing in C. elegans.
Lipidomics reveal the protective effects of a vegetable-derived isothiocyanate against retinal degeneration
Authors: Kwa Faith A. , Dulull Nabeela K. , Roessner Ute , Dias Daniel A. , Rupasinghe Thusitha W.
Published: October 2019

Background:Age-related macular degeneration (AMD) is a leading cause of blindness in the ageing population. Without effective treatment strategies that can prevent disease progression, there is an urgent need for novel therapeutic interventions to reduce the burden of vision loss and improve patients’ quality of life. Dysfunctional innate immune responses to oxidative stress observed in AMD can be caused by the formation of oxidised lipids, whilst polyunsaturated fatty acids have shown to increase the risk of AMD and disease progression in affected individuals. Previously, our laboratory has shown that the vegetable-derived isothiocyanate, L-sulforaphane (LSF), can protect human adult pigment epithelial cells from oxidative damage by upregulating gene expression of the oxidative stress enzyme Glutathione-S-Transferase µ1. This study aims to validate the protective effects of LSF on human retinal cells under oxidative stress conditions and to reveal the key players in fatty acid and lipid metabolism that may facilitate this protection.

Methods:Thein vitrooxidative stress model of AMD was based on the exposure of an adult retinal pigment epithelium-19 cell line to 200µM hydrogen peroxide. Percentage cell proliferation following LSF treatment was measured using tetrazolium salt-based assays. Untargeted fatty acid profiling was performed by gas chromatography-mass spectrometry. Untargeted lipid profiling was performed by liquid chromatography-mass spectrometry.

Results:Under hydrogen peroxide-induced oxidative stress conditions, LSF treatment induced dose-dependent cell proliferation. The key fatty acids that were increased by LSF treatment of the retinal cells include oleic acid and eicosatrienoic acid. LSF treatment also increased levels of the lipid classes phosphatidylcholine, cholesteryl ester and oxo-phytodienoic acid but decreased levels of phosphatidylethanolamine lipids.

Conclusions:We propose that retinal cells at risk of oxidative damage and apoptosis can be pre-conditioned with LSF to regulate levels of selected fatty acids and lipids known to be implicated in the pathogenesis and progression of AMD.
Systematic screening of 96 Schistosoma mansoni cell-surface and secreted antigens does not identify any strongly protective vaccine candidates in a mouse model of infection
Authors: Crosnier Cecile , Brandt Cordelia , Rinaldi Gabriel , McCarthy Catherine , Barker Colin , Clare Simon , Berriman Matt , Wright Gavin J.
Published: October 2019

Background: Schistosomiasis is a major parasitic disease affecting people living in tropical and sup-tropical areas. Transmission of the parasite has been reported in 78 countries, causing significant morbidity and around 200,000 deaths per year in endemic regions. The disease is currently managed by the mass-administration of praziquantel to populations at risk of infection; however, the reliance on a single drug raises the prospect of parasite resistance to the only treatment widely available. The development of an effective vaccine would be a more powerful method of control, but none currently exists and the identification of new immunogens that can elicit protective immune responses therefore remains a priority. Because of the complex nature of the parasite life cycle, identification of new vaccine candidates has mostly relied on the use of animal models and on a limited set of recombinant proteins.

Methods: In this study, we have established an infrastructure for testing a large number of vaccine candidates in mice and used it to screen 96 cell-surface and secreted recombinant proteins from Schistosoma mansoni. This approach, using standardised immunisation and percutaneous infection protocols, allowed us to compare an extensive set of antigens in a systematic manner.

Results: Although some vaccine candidates were associated with a statistically significant reduction in the number of eggs in the initial screens, these observations could not be repeated in subsequent challenges and none of the proteins studied were associated with a strongly protective effect against infection.

Conclusions: Although no antigens individually induced reproducible and strongly protective effects using our vaccination regime, we have established the experimental infrastructures to facilitate large-scale systematic subunit vaccine testing for schistosomiasis in a murine infection model.
A Dynamic Discrete Choice Activity-Based Travel Demand Model
Authors: Västberg Oskar Blom , Karlström Anders , Jonsson Daniel , Sundberg Marcus
Published: October 2019

This paper presents a dynamic discrete choice model (DDCM) for daily activity–travel planning. A daily activity–travel pattern is constructed from a sequence of decisions of when, where, why, and how to travel. Individuals’ preferences for activity–travel patterns are described by the sum of the utility of all travel and activity episodes in that pattern, but components of the utility functions, such as travel times, may be stochastic. In each decision stage, individuals act as if they maximized the expected utility of the remainder of the day. The DDCM-model presented allows for a detailed treatment of timing decision consistent with other choice dimensions, respects time–space constraints, and enables the inclusion of explicitly modeled uncertainties in, for example, travel time. In a case study, a model for daily planning of activity and travel on workdays is estimated whereby individuals can perform any number of trips that each is a combination of one of 1,240 locations, four modes, and six activities. Simulation results indicate that the model within sample accurately replicates timing decisions, trip lengths, and the distributions of the number of trips, tours, and trips per tour.
COSMETICS USAGE HABITS AND RELATED SIDE EFFECTS AMONG FEMALES: LITHUANIAN CASE
Authors: Šniepienė Gražina , Jonuševičienė Judita
Published: October 2019

Background. Nowadays, it is generally recognized that physical appearance is important, women are particularly interested in their aesthetic appearance and the use of various cosmetic products. The long-term usage habits of cosmetic products have influenced not only the condition of the skin and hair but also on human health.

The aim of the survey was to investigate cosmetics use habits and related side effects among females.

Methods: A quantitative survey was performed; an original questionnaire based on scientific resources was used, used data collection method - a written survey. Survey sample – 336 Lithuanian women. Data analysis was performed using the social research statistics program SPSS 25.0. Percentage frequencies were calculated for ordinal variables - averages and standard deviations. The Pearson’s Chi-Square test and the non-parametric Kruskal Wallis and Mann Whitney tests were used to detect statistically significant differences. The significance level selected was p <0.05.

Results. The survey revealed the prevalence and frequency of the use of cosmetic products by women, as well as the choice criteria for selecting cosmetic products. The side effects related to the use of cosmetics experienced by women are investigated as well as some practices and habits regarding the use of cosmetics.

Conclusions. The study shows that the choice criteria of cosmetic products differ among separate women age groups. The older women are more concerned about the composition of the products, their naturalness, and the manufacturer, while the price is less important. Most commonly used are personal hygiene products including deodorants and perfumers. The older women use less cosmetic products (p <0.05) than the younger ones. The majority of women have experienced side effects related to the use of cosmetics. The study shows that the occurrence of side effects does not depend on the number of products used. However, they are related to the use habits: women who experience side effects more often (p <0.05) use expired cosmetic products. In addition, women with side effects are less likely to use cosmetic testers.
INFLUENCE OF TECHNOLOGICAL PARAMETERS OF THE ULTRAFILTRATION PROCESS OF CITRUS JUICES ON THEIR QUALITY
Authors: Bejanidze Irina , Kharebava Tina , Nakashidze Nunu , Komcelidze Lamzira , Davitadze Nazi
Published: October 2019

Fresh fruit juices contain organic acids and mineral substances (potassium, calcium, iron, copper, magnesium, phosphorus, manganese, molybdenum, boron, iodine), and their salts, large amounts of fiber, pectin and enzymes - complex substances, that contribute to the food processing and absorption of nutritional elements. Natural citrus juices contain essential vitamins and nutrients for the human body. Therefore, they represent a good opportunity for the treatment and prevention of various diseases. With the vitamins, taken through the juice, the human body becomes more resistant to viruses and infections, stressful situations and intense physical stress, and the body’s metabolism becomes normalized. Beverages, prepared from juices improve intestinal motility and thus contribute to improving the allocation of toxic substances and slags from the organism.

The purpose of this work is the development of technological parameters of the ultrafiltration process to obtain natural juices which are sterile, resistant to precipitation and turbidity, and have a long shelf life. This paper examines the performance of the ultrafiltration process of citrus juices (lemon, tangerine, orange) and its dependence on the pressure and duration of the process, type and porosity of the membrane, the nature of the juice, and acidity. The juice composition was studied before and after ultrafiltration. It was established, that the productivity of the ultrafiltration process depends on: the duration of the process and this dependence is determined by the nature of the process: membrane type, in particular, filtration material and pressure: with an increase in membrane porosity and pressure, the productivity of the process, the volume of filtered juice, filtering speed and duration increases; the productivity of the ultrafiltration process, during the filtration both in dynamic and static mode, depends on the type and consistency of the juice: it increases with the increase of juice acidity. It was established: the general acidity (1.17%), density (1.038 g/cm3), the content of dry substances (9.9%), sugars (7.8%), including invert (7.2%), ash ( 0.26%), and vitamin C ( 20mg/ 100gr.), do not change in the course of ultrafiltration of tangerine juice. The viscosity, the content of carotenoids, cellulose and pectin decreases. The amino-acid structure practically does not change; hollow fibers detain only 6 - 8% of proteins and amino acids. For obtaining high-quality citrus juices, ultrafiltration should be carried out at a pressure 0.2MPa, on hollow fiber, in a dynamic, circulating mode.

The juices obtained by ultrafiltration on hollow fibers (AP-2.0) are sterile, resistant to precipitation and turbidity, have significantly increased shelf lives, and they retain their organoleptic properties and nutritional values.
CHARACTERIZATION OF SEVERAL WEST GEORGIAN AUTOCHTHONOUS GRAPES AND THEIR WINE STILBENES
Authors: Kharadze Maia , Vanidze Maia , Djaparidze Indira , Kalandia Givi , Davitadze Ruslan , Kalandia Aleko
Published: October 2019

The present study was conducted to determine the content of Stilbenes in the several autochthonous West Georgian grapes and wines. Stilbenes were analyzed using HPLC-UV samples and were prepared using resin (amberlite XAD2) column, C18 Cartridge Solid Phase Extraction (SPE) Waters Sep-Pak C18 (500 mg). The identification was achieved using UPLC-PDA and MS analysis. The study was conducted on the following Stilbenes and their derivatives – Astringin,  Piceid, Trans/cis resveratrol, and ε-Viniferin. The amount of stilbenes in grapes was determined as: Aladasturi-131.9±4.8  mg kg-1, Aleksandrouli 148.2±4.9  mg kg-1, Mujuretuli 215.3±7.9 mg kg-1 , Chkhaveri 77.5 ±2.5 mg kg-1, Ojaleshi 260.71±9.1mg kg-1 . In red wines the content of Stilbenes was  Aladasturi-19.17±0.5 mg kg-1, Aleksandrouli 14. 87±0.4 mg kg-1, Mujuretuli 21.36±0.5 mg kg-1, Chkhaveri 14.5±0.4 mg kg-1,  Ojaleshi 60.8±2.2 mg kg-1.
MICROPROPAGATION OF CHUKRASIA TABULARIS A. FUSS BY SOMATIC EMBRYOGENESIS TECHNIQUE
Authors: Van Minh Tran
Published: October 2019

Chukrasia tabularis belongs to the Meliaceae family, which is native to many Asian countries, including Vietnam. It is a precious wood species with beautiful wood grain, light-loving tree with evergreen leaves, widely grown in many places Cameroon, Costa Rica, Nigeria, Puerto Rico, South Africa, United States, China ... for many different purposes: planting economic forests, alternative forests, protective forest belts and urban greenery. In Vietnam, Chukrasia tabularis are usually distributed naturally in the northern, central highland and southern provinces. From Nghe Tinh onwards, there are many varieties such as Dong Nai Chukrasia tabularis (Chukrasia tabularis var. Dongnaiensis), Con Dao Chukrasia tabularis (C. tabularis sp.), small fruit Chukrasia tabularis (C. tabularis var. Microcarpa), and hairy Chukrasia tabularis (C. tabularis var. Velutina). Chukrasia tabularis often grow on well-drained soil, at an altitude of 300-800 m.asl, the annual average temperature is from 2-43oC, rainfall is 1,800-3,800 mm. Singing and development occurs in high limestone mountains, meaty soil, mixed meat, nutrient poor sandy soil at an altitude of less than 100 m. The tree is regenerated by seed but grows slowly and with high genetic diversity. Techniques of somatic embryo culture are applied to preserve and develop Chukrasia tabularis plants with urgent needs.
The microbiome, the gut–brain axis and migraine
Authors: Naghibi Malwina M , Day Richard
Published: October 2019

The gut–brain axis refers to the bidirectional biochemical pathways linking the central nervous system with the gastrointestinal tract. Research suggests that changes in the micro-organisms found in the GI tract (the gut microbiota) can affect the brain's physiological, behavioural and cognitive functions. And through this so-called microbiota gut–brain axis it has been suggested that multiple neurological and psychiatric diagnoses (including Parkinson's disease, Alzheimer's disease, anxiety, depression and migraine) may be influenced by the micro-organisms of the gut. Migraine is a common and frequently debilitating condition. It has a global prevalence of approximately 15% and is responsible for millions of lost school and work days globally every month. Migraine is characterised by repeated, severe and protracted headaches, often preceded or accompanied by nausea, sensory hypersensitivity and visual disturbances. Migraine can be managed with analgesic and prophylactic drugs, although these are not always effective and can frequently have significant side effects. Some promising phase I/II studies suggest that certain combinations of probiotics could reduce the frequency and severity of migraine symptoms, with consequent reductions in medication use. Although research into microbiome-related treatments for migraine are in their infancy, further research into the field, including larger, phase III trials, could provide many millions of migraine patients with an alternative to traditional pharmacological means of managing migraine symptoms.
Targeted, Precision Irrigation for Moving Platforms: Selected Papers from a Center Pivot Technology Transfer Effort
Authors: Lamm Freddie R. , Porter Dana O. , Bordovsky James P. , Evett Steven R. , O’Shaughnessy Susan A. , Stone Kenneth C. , Kranz William L. , Rogers Danny H. , Colaizzi Paul D.
Published: October 2019

This article is an introduction to an ASABE Special Collection of ten articles concerning center pivot (CP) technology transfer that appears in this issue of and in . The year 2018 marked the 40th anniversary of research and development of low-energy precision application (LEPA) for use with CP sprinkler irrigation systems. Since 1978, researchers, extension specialists, and industry have continued development of multiple technologies that are suitable for mobile lateral irrigation platforms. A two-year technology transfer effort with funding from the USDA-ARS Ogallala Aquifer Program (OAP) was initiated in January 2017 to promote adoption of advanced and efficient irrigation technologies and to highlight recommended practices for mobile irrigation platforms, including both CP and lateral-move (LM) systems. The articles in this Special Collection address five major topic areas: in-canopy and near-canopy irrigation application from moving platforms, site-specific variable-rate irrigation (VRI) and associated sensor technologies for moving platforms, the use of variable-frequency drives (VFDs) with CP systems, and uniformity evaluations for CP systems. While these ten articles are not inclusive of all the important advances in irrigation from moving platforms since 1978, they illustrate that continued improvement in irrigation management occurs by combining engineering and agronomic sciences. Pressurized irrigation from moving platforms is increasing in the U.S. and will be an important tool for meeting global food and water challenges. In addition to introducing and summarizing the Special Collection, this article provides additional rationale for the CP technology transfer effort. Keywords: Center pivot, Irrigation uniformity, Lateral-move sprinkler, LEPA, Linear-move sprinkler, Low-energy precision application, Site-specific irrigation, Sprinkler irrigation, Variable-frequency drives, Variable-rate irrigation, VFD, VRI.
Microbial Population Change in Anaerobic Digestion during Copper Sulfate Inhibition and Recovery
Authors: Jordaan Elsie M. , Levin David B. , Sparling Richard , Khafipour Ehsan , Çiçek Nazim
Published: October 2019

This study evaluated how feedstock with added copper sulfate (commonly used as an antimicrobial footbath solution in livestock operations) changed the performance and microbial populations of a dairy manure digester. High-throughput Illumina sequencing of the V4 region of the bacterial and the V6-V8 regions of the archaeal 16S rRNA gene in digester samples showed a significant change in the microbial community composition during addition of feedstock with copper sulfate, followed by a return to the original composition with regular feedstock. Bacterial genera that were suppressed during the inhibition period included Cloacamonas, Syntrophomonas, Butyrivibrio, and Caldicoprobacter, while the relative abundance of Acholeplasma, Desulfobulbus, Aminobacterium, Treponema, and YRC22 peaked. The dominant methanogen Methanosarcina, although initially resistant, was suppressed during inhibition, while Methanobrevibacter and Methanosphaera, prominent feedstock genera, increased. The return of the bacterial and archaeal communities to compositions similar to their previous steady states after inhibition highlights the digester’s microbial resilience and recovery potential. Keywords: . Anaerobic digestion, Copper sulfate inhibition, Illumina sequencing, Manure, Methanogens, Microbial populations, Microbiome.
NEOLIBERALISMO E SOLIDARIEDADE: BREVES APONTAMENTOS DA TEORIA CRÍTICA DO DIREITO
Authors: Pereira Neto Alexandre Nogueira
Published: October 2019

O presente trabalho tem como proposta geral analisar, dialeticamente, a política econômica neoliberal e o objetivo fundamental da solidariedade, consubstanciado no artigo 3º, I, da Constituição da República Federativa do Brasil, de 1988, à luz da perspectiva da teoria crítica do direito. Em um primeiro momento, desenvolvem-se conceitos e características do neoliberalismo e seus efeitos no espaço social da política econômica brasileira. Posteriormente, analisa-se o fundamento constitucional da solidariedade e avaliam-se seus reflexos práticos, tendo em vista os impactos que esse fundamento sofre diante da interferência da economia neoliberal nas suas tentativas de consolidação. Por último, coteja-se a política econômica neoliberalizante com o fundamento da solidariedade sob o viés da teoria crítica do direito, com o fito de investigar a (im)possibilidade de convivência desses dois elementos quando estão presentes em um mesmo ambiente social.
ANÁLISE DA REPERCUSSÃO GERAL APÓS 10 ANOS DE APLICAÇÃO: AVANÇOS, DESAFIOS E DIAGNÓSTICO EM NÚMEROS
Authors: Lobato Anderson Orestes Cavalcante , Ortiz Rodrigo Meireles
Published: October 2019

O trabalho pretende analisar alguns dos impactos proporcionados pela repercussão geral em dez anos de aplicação. Nesse intuito, aborda-se o processo de objetivação do controle de constitucionalidade da Leis no Brasil como origem da repercussão geral, para após se identificar os avanços proporcionados pelo instituto e os desafios a serem superados. Ademais, a partir dos dados coletados no site do Supremo Tribunal Federal até 08/04/2017, pretende-se verificar a repercussão geral em números, diagnosticando-se o tempo médio de julgamento para fixação de teses, os temas mais abordados, o tempo de julgamento por tema e a média de teses fixadas por mês. A pesquisa indica que o instituto detém propriedades virtuosas desde que adequadamente utilizadas. Ademais, os dados até então coletados apontam para alguns dos obstáculos a serem enfrentados diante do seu atual desempenho, como a necessidade do aumento do número de julgamentos que enfrentem o mérito da repercussão geral.
ATIVISMO JUDICIAL E A JUDICIALIZAÇÃO DOS DIREITOS FUNDAMENTAIS
Authors: Rocha Priscila Mendes , Migosky Felipe
Published: October 2019

O artigo traz apontamentos críticos acerca do ativismo judicial como forma de implementação de direitos fundamentais. O ponto de partida é o conceito de direitos fundamentais, passando-se em seguida para uma breve análise de casos onde o ativismo judicial foi empregado e, por fim, expõem-se pontos balizadores para cautelosa aplicação dessa postura proativa do Poder Judiciário. Como conclusão, reconhece-se que o juiz tem papel importante na resolução de conflitos que envolvem as políticas públicas, tocando-lhe difícil missão quando a legislação vigente é omissa ou mesmo insuficiente para a concretização das intenções constitucionais. Contudo, na mesma medida, entendeu-se que, sob esse manto, não pode o julgador acumular as funções legiferantes e judiciais, primeiramente porque estaria usurpando função daqueles que são os representantes do povo e, por fim, porque a concentração desses atos na mesma pessoa gera uma atividade judicial temerária, mostrando-se a autocontenção a melhor forma de contornar a problemática.
CONSTITUCIONALISMO E DEMOCRACIA: UMA ANÁLISE CRÍTICA DO PROCESSO ELETIVO DE MAGISTRADOS PARA TRIBUNAIS SUPERIORES DA BOLÍVIA
Authors: Burckhart Thiago
Published: October 2019

O constitucionalismo contemporâneo abriu caminho para a consolidação das “democracias constitucionais” em grande parte do globo. No entanto, embora os ideais do constitucionalismo e da democracia integraram-se sinergicamente, permanece subjacente a elas uma “tensão produtiva”. Mais recentemente, em 2009, a Bolívia introduziu em seu texto constitucional a eleição de magistrados para tribunais superiores, sendo esta uma inovação sem precedentes na história do constitucionalismo moderno. Nesse sentido, este artigo objetiva analisar criticamente o processo eletivo de magistrados na Bolívia, focalizando as possíveis contribuições desta experiência para a tensão produtiva entre constitucionalismo e democracia. O trabalho conclui que as eleições aprofundam a experiência democrática e constitucional na Bolívia, mas aponta para a necessidade de aprimoramento normativo-institucional do processo eletivo. O trabalho insere-se no campo da teoria da Constituição e da teoria política, em abordagem funcional-estruturalista, e divide-se em três partes: I – Constitucionalismo e democracia: categorias em “tensão”; II – O novo constitucionalismo boliviano: uma nova jurisdição constitucional; III – A experiência de eleição de magistrados para os tribunais superiores da Bolívia: uma análise crítica.
A FLEXIBILIZAÇÃO DO DIREITO TRABALHISTA BRASILEIRO
Authors: Kopstein Marcos Antunes , Silva Bruna Lopes
Published: October 2019

O direito do trabalho brasileiro caracteriza-se pelo caráter preservacionista, mas vê-se uma crescente flexibilização do trabalho, seja através de negociações coletivas ou de desregulamentação de normas trabalhistas. Os princípios basilares do direito laboral, principalmente o elementar princípio da proteção, regem todas as formas da relação de trabalho, mas evidencia-se uma transformação do direito do trabalho, convertendo sua lógica preservacionista para uma lógica de flexibilidade. Então, afirma-se que a flexibilização decorre das mudanças de panorama econômico, resultante de crises e advento de novas tecnologias. Nesse interim, antevê-se modificações na legislação trabalhista pátria, maiormente da Consolidação das Leis Trabalhistas, as quais demonstram claramente a flexibilização do direito laboral no Brasil.
abordagem CTS no contexto das questões de matemática do ENEM (2012-2016)
Authors: Sbrana Maria de Fátima Costa , Albrecht Evonir , Aguiar Marcia
Published: October 2019

Este relato de pesquisa está embasado em uma Dissertação de Mestrado, que teve o objetivo de analisar se a abordagem CTS (Ciência, Tecnologia e Sociedade) e a EMC (Educação Matemática Crítica) podem contribuir para o ensino contextualizado da Matemática. No primeiro momento, realizamos uma análise das questões de Matemática contempladas no ENEM (Exame Nacional de Ensino Médio), no período de 2012 a 2016, a fim de investigar se essas questões possuíam em seu contexto, questionamentos pertinentes à abordagem CTS, bem como examinar se estariam relacionadas com outras áreas de conhecimento, em uma abordagem interdisciplinar. O ENEM foi criado em 1998 com o propósito de avaliar o desempenho dos estudantes ao final da escolaridade básica, além de verificar as competências fundamentais ao exercício pleno da cidadania. Esta pesquisa é qualitativa, de caráter descritivo, tendo como base a análise de conteúdo de Bardin (2011). Dentre as 225 questões analisadas, constatamos que 62,2% não possuem em seu contexto a relação da Ciência e da Tecnologia com a Sociedade ou com outras áreas de conhecimento, sequer possibilitam questionamentos que contribuam com a formação crítica dos estudantes para o exercício da cidadania. No segundo momento, realizamos um Curso de Extensão abordando o enfoque CTS e a EMC, direcionado a professores que ensinam Matemática. Neste curso, utilizamos as questões analisadas do ENEM como instrumento de ensino-aprendizagem para discutir possibilidades de inserção dessas abordagens no ensino de Matemática. Neste relato de pesquisa apresentaremos as discussões pertinentes ao primeiro momento da pesquisa, que são as análises das questões do ENEM.
The Shereshevsky-Turner syndrome: Spontaneous growth and growth-promoting effects of estrogen replacement therapy
Authors: Koledova Ye. В. , Semicheva T. V. , Tyulpakov A. N. , Yarovaya I. S. , Peterkova V. A.
Published: October 2019

Short stature and ovarian failure are typical features of Turner's syndrome (TS). Although growth in TS has been intensively studied, few data are available concerning the influence of different karyotypes and estrogen replacement therapy on the growth of TS patients. This paper presents the first results of studying the growth of TS patients in Russia. Sixty-one girls aged 5 to 17 with TS were examined. Auxological data included parental height (Ht), target Ht, predicted Ht (1), spontaneous Ht, Ht SDS (Tanner), Ht SDS TS (1), birth length, birth length SDS, and Ht SDS for BA before and after estrogen therapy. The diagnosis of TS was confirmed by the identification of the karyotype from peripheral leukocytes. 45,X karyotype was detected in 69%, different types of mosaicism including X chromosome (45,X/46,XX; 45,X/46,X(r)x) in 16%, 46,Xi(q) and deletions of X chromosome in 10%; Y chromosome mosaicism (45,X/46,XY) in 5%. Estrogen replacement (dihydrostilbestrol orally in a daily dose of 1.0 mg) was started at BA11.0 years if no signs of spontaneous puberty were observed. The mean duration of estrogen therapy was 0.960.15 years. A moderate growth delay was seen at birth (0.950.11 Ht SDS). There was no correlation between birth length and parental height (r=0.09 for maternal and r=-0.33 for parental height, respectively). The degree of postnatal growth retardation negatively correlated with CA (r=-0.647; p0.01). Short stature was particularly evident at CA9.0 yrs (-2.460.19 Ht SDS and -3.360.20 Ht SDS, CA9.0 yrs vs. CA9.0 yrs, respectively). The karyotype (45, X or mosaicism) did not influence growth retardation either at birth (49.320.28 cm vs. 48.610.56 cm; p=0.48) or in the postnatal life (p=0.8). Estrogen appreciably accelerated the growth (0.600.14 and 0.800.15 Ht SDS TS, before vs. after estrogen, p=0.006), followed by a decrease of SDS for BA (-1.430.23 vs. -1.800.34, p=0.2). Hence, spontaneous growth in Turner girls in Russia does not appreciably differ from European standards. Short stature progressed with age irrespective of the karyotype (45,X or mosaicism). Low estrogen doses, minimizing the unfavorable effects on BA maturation, are more appropriate for replacement therapy in TS.
Androgens: A lecture
Authors: Goncharov N. P.
Published: October 2019

Androgens (Greek aner, andros - male and genesis - origin) - compounds with the properties of the male sex hormone testosterone (T). T (androst-4-en-17p-ol-3-one; molecular mass 288.41) is a derivative of androstane. In 1935, Laker from 100 kg of testes of bulls for the first time isolated 10 mg of a pure substance, which he called testosterone. Its biological activity was 10 times higher than that of androsterone known at that time. Based on a number of studies, it has been suggested that T is a 17-dihydro derivative of androstenedione. Soon, the hypothetical structure of T was deciphered and its synthesis was carried out. This was a prologue for the synthesis of dozens of derivatives of T with desired properties. Later, a large number of natural androgens secreted by the testes and adrenal glands, as well as their metabolic products excreted in the urine, were isolated from various biological environments of humans and animals. Biosynthesis and metabolism of androgens. Using various methods, including chemical-analytical, radioisotope, chromatographic, perfusion of testes, studying metabolic products excreted in the urine, it was possible to develop a conceptual scheme of androgen synthesis. Cholesterol ester, accumulated by Leydig cells of the testis, is a source of androgen formation.
A importância do apoio às exportações de setores estratégicos: uma análise do programa de incentivo exportador do BNDES nas últimas décadas
Authors: Giomo Danniele
Published: October 2019

Este artigo procura avaliar qual o impacto do programa público de financiamento às exportações do BNDES (Banco Nacional de Desenvolvimento Econômico e Social) sobre as exportações brasileiras no período de 2000 a 2017. Para cumprir esse objetivo, o trabalho utilizou-se da metodologia econométrica de Métodos dos Momentos Generalizados (GMM) e as variáveis utilizadas foram: exportações brasileiras; crédito do BNDES; renda dos dez maiores parceiros (importadores) comerciais do Brasil; taxa de câmbio real efetiva e índice de preços de commodities. Também foram analisadas estatísticas descritivas como desembolso anual do sistema BNDES para exportação por setor CNAE e exportações brasileiras. As evidências sugerem que o programa BNDES tem impacto positivo e significativo sobre o valor total exportado, além de estar direcionando os recursos para os setores exportadores estratégicos para o desenvolvimento nacional.
Behavioural Language of Preterm Infants: Cardiorespirography and Video Recording of Motor Behaviour as an Integration of the Newborn Indiviualized Developmental Care and Assessment Program (NIDCAP) Observation
Authors: Ferrari F. , Lucaccioni L. , Ori L. , Talucci G. , Cuomo G. , Bertoncelli N.
Published: October 2019

Understanding early preterm infants’ strengths, vulnerabilities, thresholds to stress and disorganization, and behavioural state regulation is of great importance in view of the daily care in the NICU and stabilization of preterm infants. Preterm infants display observable behaviours along three main systems: the autonomic, the motor and the state systems. These behaviours according to the NIDCAP method are coded and recorded on a score sheet based on naturalistic observation, performed with unaided eyes.
“Who is that masked man?”
Authors: Alberts Jeffrey R.
Published: October 2019

In 1933, The Lone Ranger was a favorite on U.S. radios. In 1946, the show debuted on the new medium of television and became a cultural icon in the States. The Lone Ranger character was a mysterious, heroic cowboy. He wore a black mask and did good with humble anonymity. At the end of each episode, after a successful, selﬂess exploit, as our hero rode oﬀ on his white steed with his trusted Indian companion, grateful townspeople would ask, “Who is that masked man?”
Transformative teaching in Higher Education for Sustainable Development: facing the challenges
Authors: Förster Ruth , Zimmermann Anne B. , Mader Clemens
Published: October 2019

Are teachers ready to support sustainability transformations in tertiary education? We frame major teaching challenges within transformative learning theory and offer a schematic model of transformative learning including liminality and emotions.
POLITIK BALAS BUDI, BUAH SIMALAKAMA DALAM DEMOKRASI AGRARIA DI INDONESIA
Authors: Puri Widhiana Hestining
Published: October 2019

Pemilihan umum menjadi instrumendemokrasiyang berprinsip dari, oleh, dan untuk rakyat. Kompetisi dan komunikasi jamak dilakukan dalam meraih dukungan, salah satu caranya dengan memanfaatkanpolitik etis atau politik balas budi. Filosofi masyarakat timur yang menjunjung tinggi kebersamaan dan solidaritas mendorong hal ini relatif efektif dalam mobilisasi massa. Permasalahan muncul manakala hal ini harus dibayar mahal oleh masyarakat dengan pola kepemimpinan pemerintahan yang tidak aspiratif. Dukungan masyarakat diperlukan, namun jangan sampai menjadi bumerang yang merugikan masyarakat apalagi jika melanggar ketentuan undang-undang. Melalui model penelitian  hukum normatif/ deskstudy, ditemukan bahwa demokrasi di tingkat desa mempertemukan nilai tradisional masyarakat dengan hukum formal yang modern. Hal ini pada akhirnya akan mengancam upaya pencapaian keadilan agraria bagi masyarakat.