bluuebunny/crossref_metadata_2025 huggingface dataset:
Mujeres Pioneras en Psicología y Educación: Visibilizando el papel de las mujeres en el ámbito de la psicología educativa
Authors: Pérez Bravo Mª Dolores
Published: January 2025

La invisibilización de las mujeres es un fenómeno cultural patriarcal en el que el papel de las mujeres ha sido continuamente discriminado, silenciado y desvalorizado a lo largo de la historia en todos los ámbitos de la sociedad, incluso en el científico. La Psicología es una ciencia en la que, al igual que en otras, las mujeres han sido invisibilizadas a través de diferentes mecanismos de discriminación (territoriales, jerárquicos, institucionales, …). Visibilizar las genealogías de psicólogas es una tarea necesaria para poder restaurar, por justicia social, el reconocimiento social que se les ha negado. El trabajo que se presenta es una experiencia educativa realizada con alumnado de formación inicial del profesorado en el que, mediante una metodología de Aprendizaje Basado en Retos (ABR), se pretende rescatar del ostracismo histórico a las mujeres pioneras en Psicología y Educación, de manera que, se valoren su papel y sus contribuciones científicas a esta rama de la ciencia. Es crucial visibilizar las aportaciones de las mujeres en los materiales didácticos (López-Navajas, 2014), por ello, el resultado de esta experiencia ha sido el diseño y la creación, por parte del alumnado participante, de diferentes materiales educativos y recursos didácticos sobre las distintas mujeres psicólogas pioneras seleccionadas por los grupos de trabajo, que fueron difundidos en las redes sociales.
Pensamento Computacional e Literacia Estatística no 1.º Ano de Escolaridade
Authors: Santos Sobral Letícia , Pereira Costa Neves Margarida , Rolo Simões Maria Inês , Neves Rodrigues Rita , Freitas Yelitza , Costa Cecília , Martins Fernando
Published: January 2025

O Pensamento Computacional (PC) é uma capacidade essencial para a integração na sociedade, sendo fulcral o seu desenvolvimento desde os primeiros anos de escolaridade. Este estudo apresenta a implementação de uma Prática de Ensino Exploratório (PEE) que procurou desenvolver esta capacidade matemática através do tema Dados e Probabilidades, numa turma do 1.º ano do 1.º Ciclo do Ensino Básico, com foco na literacia estatística dentro do contexto do Dia Mundial da Água. Deste modo, a PEE desenvolveu-se em quatro fases, de forma colaborativa entre três professoras estagiárias, com supervisão do professor titular de turma, tendo-se realizado uma investigação estatística com os alunos. Neste contexto, os alunos, em grupos de dois e três elementos, recolheram e interpretaram dados, construíram uma representação gráfica e, por fim, partilharam as tarefas realizadas com os colegas. A sessão incluiu a recolha de dados através de gravações de áudio, fotografias, trabalhos escritos dos alunos e notas de campo dos professores estagiários, tendo sido garantido o anonimato dos participantes envolvidos.
Com a prática desenvolvida evidenciou-se o desenvolvimento das dimensões Abstração, Decomposição, Algoritmia, Reconhecimento de padrões e Depuração do PC. Através das interações ocorridas entre os alunos foi ainda possível observar que a prática promoveu um ambiente de aprendizagem colaborativo.
Conclui-se que a PEE não promoveu apenas o desenvolvimento do PC e da literacia estatística, mas também incentivou o pensamento crítico, a colaboração e a entreajuda entre os alunos, evidenciando-se a importância do desenvolvimento deste tipo de práticas desde o início da escolaridade.
Analysis of exponential stability and L1-gain performance of positive switched impulsive systems with all unstable subsystems
Authors: Zhang Xiukun , Sun Yuangong , Zhu Xingao
Published: January 2025

This article investigates the exponential stability and L1-gain performance of time-varying positive switched impulsive systems even when all modes are unstable. By employing the discretized switched copositive Lyapunov function approach and the analytical method developed for positive systems, we derive a sufficient condition to ensure the exponential stability for such systems. An algorithm for computing the stability region of admissible dwell time is also introduced. Furthermore, building on this stability result, the L1-gain performance of positive switched impulsive systems is further studied. Finally, numerical examples are presented to demonstrate the validity of our results.
Medium-sized and large bodied mammals of Marshall Wetlands, a proposed protected area in Liberia
Authors: Gweh Allen , Bailey Allison , Palmeirim Ana Filipa , Poultolnor Jackson , Toe Henry , Crowley Wing , Machalaba Catherine , Desmond James , Desmond Jenny , Prist Paula R.
Published: January 2025

Liberia comprises 43% of the upper Guinean tropical forest of West Africa, a global hotspot with high levels of biodiversity and endemism succumbing to accelerated rates of deforestation. Due in part to the country’s past civil war, knowledge about much of Liberia’s remaining local biodiversity is limited. To help fill this gap, we surveyed medium‑sized and large‑bodied mammals in a proposed protected area, the Marshall Wetlands, in Margibi County, Liberia. Using 21 camera traps, in an effort of 33,120 hours, and track surveys along trails, between July 2022 and May 2023, we confirmed the presence of 13 medium‑sized and large mam‑ mal species. Of these, four species have some degree of threat in the IUCN Red List. Despite its proximity to the capital city of Monrovia, the Marshall Wetlands comprise significant biodiversity, highlighting its conservation value and reinforcing the value of improved protected status.
The effect of Curcuma longa on fasting blood glucose, MMP-9 and IFN-γ in diabetes mellitus: an experimental study
Authors: Ovaditya Shafira Zahra , Brilliantika Surya Pratama , Chodidjah Chodidjah , Sumarawati Titiek
Published: January 2025

Background: Turmeric (Curcuma longa) contains curcumin as an active ingredient that has ability as a potent antioxidant and antiinflammation. Turmeric extract can improve glucose level and surpress micro and microangiopathy complication in Diabetes Mellitus Type 2. The aim of this study was to investigate the role of turmeric extract administration on fasting glucose level, MMP-9, and IFN-γ.
Methods: Experimental PostTest Only Control Group Design study was conducted. Twenty four Wistar rats aged 2 months weighing 180-200 grams were adapted for 2 days, divided into 4 groups randomly: negative control group induced by STZ-NA only (P1),  positive control group induced by STZ-NA and received metformin 45mg/kgBW/day (P2), treatment group induced by STZ-NA and received  turmeric extract 200mg/kgBW/day (K1), and  ), treatment group induced by STZ-NA and received   combination of metformin 22,5mg/kgBW/day and turmeric extract 100mg/kgBW/day.  The levels of fasting glucose serum were measured by spectrophotometric method, while ELISA measured the levels of MMP-9 and IFN-γ.
Results: Mean + SD Fasting blood glucose level was decreased respectively from K1, K2, P1 and P2 (277.00 + 4.00, 100.00 + 2.00, 98.04 + 3.00, 92.00 + 3.00 mg/dl). MMP-9 level was decreased respectively from K1, K2, P1 and P2 (653.09 + 18.00, 328.00 + 14.00, 156.00 + 4.00, 131.00 + 4.00 ng/ml). IFN–γ level was decreased respectively from K1, K2, P1 and P2 (300 + 16.00, 85.00 + 3.00, 61.05 + 2.04, 49.00 + 1.09 ng/ml.) Kruskal Wallis test for Fasting blood glucose, MMP-9, dan IFN–γ shows significant differences among groups. (p=0.004, p=0.004, dan p=0.004). Using post hoc test, all groups significantly differ with p=0.000.
Conclusion: The administration of turmeric extract improves fasting glucose level, MMP-9, and IFN-γ in type 2 DM Wistar rats
Mechanism of oxidative stress in obesity
Authors: Antara Gede Eka Rusdi , Maliawan Sri
Published: January 2025

Reactive oxygen species (ROS) levels are strongly linked to obesity and related diseases, particularly insulin resistance and type 2 diabetes. ROS, on the other hand, are thought to be important in intracellular signaling, which may be required for insulin sensitivity. Many theories have been developed to explain this apparent paradox, which has helped us understand this important small molecule better. While many intracellular ROS production sites have been identified, mitochondrial-generated ROS remains a major contributor in most cell types. Some factors described in this review influence mitochondrial ROS generation. Furthermore, this review has demonstrated the need for a new sensitive approach to quantifying ROS.
Medicinal Plants - A Promising Breakthrough in the Management of Alzheimer's Disease Progression Compared to NSAID: A Systematic Review
Authors: Sugianto Paulus , Ferriastuti Widiana , Ritarwan Kiking , Tampubolon Dwi Putri Rahayu
Published: January 2025

Treatment of Alzheimer's Disease is currently limited only to slowing the progression of the symptoms, not curing the disease. Current FDA-approved therapies such as Donepezil, Tacrine, Galantamine, Rivastigmine, and Memantine have quite disturbing side effects, as well as the mechanism of action of these drugs, which is dominated by working as AChE inhibitors. On the other hand, the hypothesis for Alzheimer's causes is varied. Another study also states that Non-Steroid Anti-Inflammatory Drugs (NSAIDs) can be given to people with Alzheimer's. However, the reports were conflicting as one study stated that NSAIDs can help reduce the risk of Alzheimer's; on the contrary, other studies have argued that giving NSAIDs to people with Alzheimer's is not necessary. Despite administering Alzheimer's drugs and NSAIDs, which have adverse side effects on long-term use and high doses, the administration of traditional medicines and medicinal plants can be a good solution due to lower side effects than common drugs, less risk, easy access and affordable. These medicinal plants have several mechanisms to counter the hypothesis that causes Alzheimer's disease.
The impact of COVID-19 vaccination for healthcare workers on the SARS-CoV-2 antibody titers in a tertiary hospital in Jakarta, Indonesia
Authors: Bur Rika , Dewi Febby Elvanesa Sandra , Virmandiani  , Kartikawati Yosanti Elsa , Gebrina Meutia , Fauzi Aditya Rifqi , Mulyawan Duddy , Budhiyani Ni Sayu Dewi
Published: January 2025

Background: Healthcare workers (HCWs) get priority access to the coronavirus disease 2019 (COVID-19) vaccination since they are at high risk of infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In Indonesia, an inactivated SARS-CoV-2 vaccination was utilized to generate an antibody response against SARS-CoV-2 infection in healthcare workers. However, data on the kinetics of antibodies generated by this vaccination remains inconsistent. This study aimed to assess quantitative antibody titers on the 28th and 90th days after the second dose of COVID-19 immunization.
Methods: This prospective cohort study involved 189 HCWs. The samples were analyzed by Roche® Elecsys Anti-SARS-CoV-2 serology test for quantitative SARS-CoV-2 total antibody. Data were analyzed using STATA version 17 for Windows.
Results: Most of the subjects (75.1%) were females, with a male-to-female ratio of 1:3. Most subjects are medic (68.8%), do not have comorbid (75.8%), have not been infected with Covid-19 (73.5%), and not a close contact (55%). Previous COVID-19 infection affects antibody titers significantly (p<0.0001). Moreover, quantitative antibody titers differ significantly between 28- and 90-days following the second dose of Sinovac vaccination (p<0.0001). However, age, gender, profession, comorbidity, and history of close contact did not significantly associate with antibody titers (p=0.150, p=0.105, p=0.367, p=0.063, and p=0.696, respectively).
Conclusions: Our study shows that antibody titers on 90-days following the second dose of COVID-19 vaccination are significantly lower than after 28 days. Moreover, antibody titers on survivors are higher than on those who have not been infected. Further multi-institutional study with a larger sample and longer follow-up is necessary to clarify and confirm our findings.
Declining in estimated glomerular filtration rate of chronic kidney disease patients after Ramadan fasting is independent of interleukin-6 serum level
Authors: Abdullah  , Fitri Jamil Kurnia , Dharma Lindarto  , Salwani Desi , Muhsin  , Andri Baftahul Khairi  , Syukri Maimun
Published: January 2025

Introduction: Ramadan fasting is compulsory for adult Muslims with no medical problems. The role of Ramadan Fasting in increasing or decreasing estimated Glomerular Filtration Rate (eGFR) of chronic kidney disease (CKD) patients is still debatable. Interleukin-6, a pro- and anti-inflammatory cytokine has previously been associated with progression of eGFR in CKD patients. This study aimed to determine the role of Ramadan fasting on the eGFR of CKD patients and its correlation with IL-6.
Methods: As many as 35 CKD stage 3 and 4 patients who fasted for a minimum of 14 hours per day at 21 days in Ramadan were included in the study. Parameters of hematology, kidney, and metabolic as well as eGFR and IL-6 serum before and after Ramadan fasting were compared to examine effect of Ramadan fasting on CKD progression and the correlation with IL-6 serum level.
Results: This study showed significantly decreased of eGFR in CKD stage 3-4 patients after Ramadan fasting (p<0.001) that was parallel with significantly increased of serum creatinine level (p<0.001). Additionally, the study also showed decreased IL-6 serum level after Ramadan fasting. However, declining eGFR is not correlated with decreased IL-6 serum level, revealing that decreased eGFR in CKD stage 3 and 4 patients after Ramadan fasting is not correlated to IL-6 serum.
Conclusion: This study showed for the first time that declining in eGFR of CKD patients after Ramadan fasting is IL-6 serum independent.
Correlation of 5-minutes heart rate variability with health performance of resident physicians in covid 19 pandemic
Authors: Ridwan Muhammad , Pamungkas Subhan Rio , Husna Fauzul , Syafrida Willa Mutia , Lestari Inda
Published: January 2025

Introduction: Resident physicians have high exposure risk and infection rate of Covid 19. Their health condition is one of determining factors in Covid-19 prevalence. Thus, we evaluated the following variables: exercise capacity, Resting Heart Rate (RHR), several body compositions from Bioelectrical Impedance Analysis (BIA), and Body Mass Index (BMI) that resemble health conditions. Then, those variables were correlated with HRV (Heart Rate Variability), which strongly influences fitness and immunity.
Method: This cross-sectional study was conducted from March to September 2021 and involved 149 resident physicians in medical faculty of Universitas Syiah Kuala. The basic data of respondents was filled in through questionnaires and other data obtained from measuring HRV, RHR, 6 minutes walk test (6mwt), BIA, and BMI. We used Spearman's correlation to assess the relationship of each data with HRV.
Result:  Standard deviation of NN interval (SDNN) and low frequency (LF) negatively correlated with RHR (p = 0.000, r = -0.400 and p = 0.000, r = -0.332, respectively); BMI (p = 0.004, r = -0.233 and p=0.024, r=-0.185); and BIA variable (total fat) (p = 0.000, r = -0.286 and p=0.000, r=-0.319). SDNN and LF positively correlated with 6MWT (p= 0.040, r= 0.169 and p=0.021, r=0.189).
Conclusion Increasing exercise capacity plays an important role in increasing fitness levels, which is marked by increased HRV values. While the increase in RHR, BIA, and BMI values ​​causes a decrease in HRV values ​​, indicating a decrease in fitness level.
The description of mothers’ knowledge of exclusive breastfeeding according to the maternal characteristics at Dr. Ramelan Central Naval Hospital, Surabaya
Authors: Mantofa Anne Marie , Hsieh Peter Prayogo , Mapantow Fricillia , Wongsodiharjo Monique , Chandra Exousia Kirana , Handoyo Devina Theo Hengky , Pikir Rizqi Rokhmadoni , Ardana Dian
Published: January 2025

Background: Exclusive Breastfeeding supports optimal growth and development and prevents kids from getting sick. Knowledge about Exclusive Breastfeeding is one of the most important factors affecting its practice. This study aims to know about knowledge level based on mothers’ characteristics.
Methods: This descriptive study, which involved 39 respondents, was conducted in the Pediatric Wards and Outpatient Clinics of Dr. Ramelan Central Naval Hospital Surabaya in October 2019 using a questionnaire. The focus of this study is knowledge about Exclusive Breastfeeding based on the mother’s age, educational level, employment, counseling, and birth orders. The inclusion criterion is mothers with 0-6 month-old babies. The exclusion criterion is a mother who is unable to speak Bahasa. We classify knowledge levels as good, average, and insufficient based on the questionnaire.
Result: This study includes 39 respondents. There are 21 out of 26 (80.8%) mothers in the group of 20-35 years old who have better knowledge. Fifteen out of 16 (93.8%) mothers who graduated from high school have better knowledge. There 26 out of 31 employed mothers (83/8%) have better knowledge. We also found that 22 out of 25 (88%) who’ve got counseling have better knowledge. Of 21 mothers with firstborns, there are 20 mothers (95.2%) who have better knowledge.
Conclusion: Younger age, higher educational level, employed mothers, mothers who’ve got counseling, and those with first-born tend to have better knowledge on Exclusive Breastfeeding.
Chronic limb-threatening ischemia Rutherford VI, successful infra inguinal stenting: a case report
Authors: Zulfa Putri Oktaviani , Habibie Yopie Afriandi
Published: January 2025

Introduction: Chronic limb-threatening ischemia (CLTI) is a remarkably morbid condition that causes significant mortality, limb loss, pain, as well as reduce health-related quality of life in those who are affected. The cornerstone of CLTI therapy is revascularization, which can lower the amputation rate.
Case description:  A diabetic type II 68-year-old female patient presented with complaints of pain, swelling, and itching in the left leg that was felt for approximately 1 month ago. The wound persists although the ankle was already amputated. CT-angiography showed total occlusion in 1/3 distal of left femoral artery and no visualization of left popliteal artery. She was diagnosed as left CLTI femoral popliteal Rutherford VI TASC II type D with ischemic rest pain. The patient planned for an endovascular revascularization procedure. Victory 14 wire 0.014” was inserted but recanalization did not penetrate, continued with Victory 18 wire the lesion could penetrate. Digital Subtract Angiography (DSA) evaluation found significant residual stenosis, thus continued using Abbott Supera peripheral stent system. The patient was successfully treated showed left femoral artery was seen well visualized with TIMI flow 3, left popliteal artery was still seen 50% no significant residual stenosis with TIMI flow 2. Followed up after 3 months, she did not complain any ischemic pain at left leg.
Discussion: The Supera peripheral stent system was developed to withstand the femoropopliteal artery's unique stressors. There have been few studies on the use of supera stenting in complex CLTI, and the primary patency at 1 year was 77% in lesions measuring 92-236 mm. In this case report, the procedure was successfully applied in complex CLTI (mean length >200mm) with no restenosis and repeat target limb revascularization after one year of procedure.
Conclusion: We successfully performed revascularization using supera stenting, and the femoropopliteal artery showed good TIMI flow results. In CLTI patients, stenting may be an option to lower the risk of major lower limb amputation.
Mozart’s or murotal, which is more effective for spatial memory? an experimental study on mice (Mus musculus)
Authors: Muhammad Akbar Reza , Dyah Yuniati  , Farindra Irmawan , Fitriyah Fifi Khoirul , Algristian Hafid
Published: January 2025

Introduction: Many studies have found the effect of Mozart’s music on the spatial memory of humans, but there are still very few studies that examine the effect of the Murotal Alquran approach on spatial memory improvement. This study aimed to evaluate the effect of Mozart's classical music and the Murotal approach on improving spatial memory in mice. This is an experimental study with 24 adult BALB/c male mice.
Method: The mice were divided into four groups: K (untreated control), P1 (Murotal approach with surah Al-Fatihah and Al-Baqarah by Qori' Al-Mathrud), P2 (Mozart’s classical music approach "Sonata in D for two pianos KV448-Allegro con spirito"), and P3 (combined approach). Each group was placed in a cage and treated for 2 hours/day for 20 days. The memory level was measured with an eight-arm radial maze instrument for ten days. The data were analyzed with non-parametric Kruskal Wallis and Mann-Whitney tests.
Result: This study found there were no significant differences between groups toward increasing spatial memory. The highest and fastest memory score was in the P3 group compared to the others.
Conclusion: There is no difference in the effect between classical music Mozart’s and Murotal approach on increasing the spatial memory of mice (Mus musculus), but mice given a combination of approaches have a better level of spatial memory with a higher level of aggressiveness.
Radar plot analysis of Helicobacter pylori detection in North Peninsular Malaysia
Authors: Mohamad Che Wan Sharifah Robiah , Arip Yahya Mat , Manaf Uyub Abdul , Markon Marni Azera
Published: January 2025

Introduction: Helicobacter pylori (H. pylori) infection is one serious disease that could result in complications such as gastritis, peptic ulcer and gastric cancer. Both invasive and non-invasive methods have been used to detect the infection, however the best detection depends on the clinical setting. One way to determine this is by graphical radar plot analysis, as it provides practical and useful data for many clinical aspects. The aim of this study was to investigate the prevalence rate of H. pylori ureA genotypes infection with a graphical technique.
Method: We conducted a cross-sectional study in which data was collected from patients with infection symptoms in north peninsular Malaysia. All eligible subjects were required to perform a simple clinical procedure to provide their cell and saliva samples. Subjects were also examined by the medical staff based on their symptoms. Detection of H.pylori in the samples were conducted with three different detection methods such as culture, biopsy, saliva and the combination of thee three methods.
Results: Biopsies were cultured and revealed 19.2% (48/250) of the patients had H. pylori infection. However, when PCR and culture were combined, the prevalence of H. pylori infection jumped by three times to 59.6% (149/250), indicating that PCR on biopsies and saliva was more sensitive. Males who were not Malay and Malay males in the age range of 41 to 60 were found to have significantly different rates of H. pylori infection (p 0.05), according to age group. According to ethnicity, 49.5% (28/58) Malay men were infected compared to 68.1% (62/91) non-Malaysia men (p0.05), while there was no difference between 64.2% (34/53) non-Malaysia women and 51.1% (23/45) Malay women.
Conclusion: This study found that saliva method is accurate for the identification of H. pylori. This approach has several advantages that could be helpful to patients worldwide, thus diagnosis and treatment can be done earlier to prevent complications.
Mechanism of neurological deficit improvement through analysis in cerebral artery stenosis, Endothelial Progenitor Cells (EPC), Asymmetric Dimethylarginine (ADMA), Malondialdehyde (MDA), and Superoxide Dismutase (SOD) after balloon angioplasty procedure in ischemic stroke patients
Authors: Musadir Nasrul , Soetojo  , Syahrul  , Sudiana Ketut , Utomo Budi , Muhammad Hamdan  , Usman Fritz Sumantri , Siti Pariani
Published: January 2025

Link of Vodeo Abstract: https://youtu.be/tOBWYoEAbiw
 
Backgrounds: Balloon angioplasty is one of the endovascular procedures which aims to open atherosclerotic stenosis or occlusion of the cerebral blood vessels. Balloon angioplasty has been performed on ischemic stroke patients with arteriosclerotic stenosis. However, the procedure's outcomes vary, and no microcellular indicator has become a standard for balloon angioplasty.
Methods: NIHSS examination and Digital Subtraction Angiography (DSA) were performed on 35 ischemic stroke patients. NIHSS examination is used to determine the severity of neurological deficits. At the same time, Digital Subtraction Angiography (DSA) is a diagnostic procedure to determine the location and size of the stenotic lesion in the arteries. Patients underwent several laboratory biomarker analyses, including EPC, ADMA, MDA and SOD, followed by balloon angioplasty. Afterward, repeat the DSA procedure. EPC, ADMA, MDA and SOD were re-analysed seven days later and NIHSS was re-examined thirty days after balloon angioplasty.
Results: Stenosis, EPC (p<0.001), MDA (p=0.001), SOD (p=0.001), and NIHSS (p<0.001) have significant output before and after balloon angioplasty (p<0.001). EPC and SOD significantly correlate with neurological deficits alteration (p<0.05). EPC and SOD have a cut-off value of 50% improvement in neurological deficits. EPC and SOD significantly improve neurological deficit (p=0.008 and p<0.001).
Conclusion: The mechanism of neurological deficit improvement in balloon angioplasty procedure happened through the elevation of EPC and SOD levels. The outcomes of balloon angioplasty could be estimated by measuring the EPC and SOD values as the standard for indicators adjustment to measure clinical progress after balloon angioplasty in ischemic stroke patients.
Bevacizumab and triamcinolone acetonide intravitreal effect on Transforming Growth Factor Beta (TGF-β) and Plasminogen Activator Inhibitor-1 (PAI-1) expression in open globe injury model
Authors: Abiyoga Kautsar , Delfitri Lutfi  , Yulia Primitasari  , Citra Dewi Maharani  , Clarisa Finanda  , Wimbo Sasono  , Nurwasis  , Evelyn Komaratih  , Joko Legowo
Published: January 2025

Introduction: Triamcinolone acetonide (TA) and bevacizumab have anti-inflammation and anti-proliferation in the wound-healing process caused by ocular injury. There was no medicament to treat ocular injury besides corticosteroids and anti-VEGF, but their comparison is not yet elucidated. This study aimed to compare the effects of injection of intravitreal triamcinolone acetonide and bevacizumab in an expression of TGF-β and PAI-1 in an experimental rabbit model of open-globe injury (OGI). TGF beta and PAI-1 have an important role in the hemostasis of the wound healing process, wherein the eye, the wound healing process should not occur excessively because it can cause PVR (unlike wound healing in the skin or other organs in the body).
Methods: This study was an experimental study of 30 eye rabbits with an OGI model. Six eyes as control and 24 eyes received treatment for 21 days. Thirty Male New Zealand rabbits and we make OGI in the superotemporal quadrant of the right eyes by making a 5 mm circumferential incision, 6 mm behind the limbus. TA and bevacizumab were treated in different groups. The subjects were divided into several groups: A) OGI group (PC), (B) OGI with intravitreal TA group 3 days after (T3), (C) OGI with intravitreal TA group 7 days after (T7), (D) OGI with intravitreal bevacizumab group 3 days after (B3), and (E) OGI with intravitreal bevacizumab group 7 days after (B7). A negative control group (NC) was randomly selected, including five left eyes from the treatment group (n = 6 each). All eyes were examined and evaluated by measuring the expression level of TGF-β and PAI-1. Normality test was done using Shapiro-Wilk, and the expression was compared using One-way ANOVA and Tukey post-hoc test.
Results: The expression of PAI-1 was significantly lower in the treatment group than in the control group (PC) (PC = 10,08 ± 1,23 %, p-value 0,0444). However, the expression of TGF-β was higher in the treatment group compared to the control group (PC) (PC = 6,60 ± 3,30 %, p-value 0,0228).  
Conclusion: Triamcinolone acetonide and bevacizumab treatments after OGI significantly weakened the upregulation of PAI-1 but could not reduce TGF-β expression in the retina and wound site tissue. It reduces the risk of developing posttraumatic complications of proliferative vitreoretinopathy (PVR).
Scleromalacia perforans in young patient: a unique case
Authors: Karima Annisa , Lutfi Delfitri , Awalia  , Zuhria Ismi
Published: January 2025

Link of Video Abstract: https://youtu.be/gC8cCxUUSQc
 
Background: Scleromalacia perforans is a systemic autoimmune disease such as rheumatoid arthritis, lupus, and Wegener's granulomatosis that may compromise vision and globe integrity. The great challenge to treat disease is determined by the genetic examination. This case report aims to describe a unique case of Scleromalacia perforans in young patient.
Case description: A 19-year-old female with a progressed protrusion of the left eye since she was 1 year old. Six years ago, she had redness, worsen protrusion, photophobia, tearing, and pain, but resolved without treatment. Her cousin had the same condition but refused to continue the examination. Visual acuity of the left eye was no light perception with 4x4 mm of corneal leukoma, and 360 degrees of anterior scleral ectasia covered with conjunctival neovascularization. USG showed posterior vitreous detachment and 28,9 mm axial length. ANA test and HLA B27 were normal, positive hypermobility joint, and Rheumatologists ruled out the possibility of autoimmune disease. Myoconjuctival enucleation was performed with a dermis fatty graft for cosmetics, and histopathological examination showed nonspecific chronic inflammation.
Conclusion: Scleromalacia perforans is a rare case that is strongly believed to have an association with systemic autoimmune disease. Collaboration between ophthalmologists, rheumatologists, and geneticists is essential to manage this case.
Clinical improvement of gastroesophageal reflux disease (GERD) patients with warm ear stimulation, initial exploratory study on the anterior branch of the vagal nerve (Jacobson's nerve)
Authors: Saleh Arman Yurisaldi , Zakaria Hasballah , Allya Paramita Koesoema  , Retno Yulianti  , Prabowo Imam , Taufiq Fredrik Pasiak
Published: January 2025

Link of Video Abstract: https://youtu.be/mVByi-Qg-xo
 
Introduction: Jacobson's nerve, also known as the auricular branch of the vagus nerve, is situated on the medial part of the earlobe. Research has demonstrated that electrical stimulation of this nerve can influence various aspects of gastrointestinal motility and function. This study investigated how warm stimulation affects Jacobson's nerves as an adjuvant therapy in patients with gastroesophageal reflux disease (GERD).
Methods: The investigation was carried out using a single-blind design, wherein the participants were unaware of their assigned group and the nature of the ear-warming therapy they were getting, whether genuine or placebo. The present study involved a sample of 15 individuals who were diagnosed with gastroesophageal reflux and had undergone medical treatment. The participants were allocated into three distinct groups for the study. Group 1 was administered anti-gastritis medication and instructed to utilize ear warmers. Group 2 was given a placebo medication and required a device resembling an ear warmer. Lastly, Group 3 was solely administered anti-gastritis medication without additional ear warmers instructions.
Results: This study showed a significant difference between the three groups after the intervention (p = 0.03). Post-intervention comparison between groups 1 and 3 revealed a significant difference [9 (3-11) vs 15 (14-16), p = 0.008].
Conclusions: Warm stimulation can serve as a viable and secure supplementary therapeutic approach for individuals diagnosed with gastroesophageal reflux disease (GERD).
Immunohistochemical examination of recurrence and giant cell tumor specificity, is it correlated? cohort retrospective study
Authors: Surachman Achmad Jadi Didy , Kamal Achmad Fauzi , Septelia Inawati Wanandi , Siregar Nurjati Chairani , Rahyussalim  , Alida Roswita Harahap , Dewi Soemarko Sumaryani
Published: January 2025

Link of Video Abstract: https://youtu.be/h3ku5ujtEY4
 
Introduction: GCT is a benign tumor that has an aggressive local character. GCT recurrence after disinfection still often occurs. The reasons for treatment failure and triggering a recurrence are believed to be the role of the accumulation of stem cells in promoting tumor initiation and recurrence.
Methods: Study Cohort Retrospective cohort in patients who had undergone surgery with a diagnosis of GCT at RSUPN Dr. Cipto Mangunkusumo in 2017-2022. The subjects were separated into two groups, recurrence patients and non-recurrence patients. The tissue biopsy will be assessed with ALCAM+, Oct4, and Stro-1 biomarkers for tumor stem cells.
Results: A total of 38 patients were diagnosed with Giant Cell Tumor. There were 31.6% of recurrent patients with an age range between 31-40 years and 41-50 years. The most common location is the Distal Radius with a score of 41.7% in recurrent patients and 38.5% in non-recurrent patients. Based on the data, the expression of ALCAM+, OCT4 and Stro-1 did not have significant differences between the two groups. The Recurrence group in p63 was expressed more than in the Non-Recurrence group p=0.002. In CD147, the Recurrence group was also expressed more than in the Non-Recurrence group p=0.003
Conclusion: Increased expression of ALCAM+, OCT4, and Stro-1 occurred in Recurrence and Non-Recurrence patients, although Stro-1 appeared to be more sensitive in detecting GCT progression, but was not statistically different. CD147 and p63 are statistically different between recurrence and non-recurrence.
Preliminary study: the future insight of relationship between nutrigenomic risk and sepsis
Authors: Veterini Anna Surgean , Semedi Bambang Pujo , Airlangga Prananda Surya , Rejeki Purwo Sri , Firdaus Khildan Miftahul , Mutiar Airi , Adi Annis Catur , Sumara Rauzan , Meirawan Rizky Fajar
Published: January 2025

Link of Video Abstract: https://youtu.be/K5y8Rmm7JZk
 
Introduction: In field observations, we frequently encountered cases of sepsis at a young age and rarely in older individuals. Most cases are caused by a bacterial infection, which causes pneumonia that progresses to septic shock. There are several possible causes of infection and subsequent septic shock. Among these, certain genetic code abnormalities cause disturbances in nutrient metabolism, which facilitates the emergence of infections. This study aimed to explore the nutrigenomic patterns in patients with septic shock.
Methods: Nutrigenomic examination was performed at the General Academic Hospital in Surabaya, Indonesia, to determine the micronutrient genotype risk in patients with septic shock. We compared cases of septic shock with control groups containing normal subjects to identify a unique pattern in the nutrigenomic results between these two groups. DNA testing was in collaboration with Nutrigenme, using saliva and buccal swabs. The data were analyzed using the chi-square test and all statistical analyses were performed using the R statistics software.
Results: The results of the saliva testing demonstrated that there was an endurance ultra-risk category (PGC1a, rs8192678; genotype GG) in the control group; however, this category was not observed in the case group. In addition, the genomic risk of vitamin C was elevated in the septic shock group (Group A) but was typical in the control group (Group B).
Conclusion: We observed a deletion in GSTT1 rs2266633 in the sepsis group, which may play a role in the development of sepsis. Furthermore, we discovered that the control group exhibited an ultra-type risk for endurance, suggesting that the ability to extract oxygen and frequent exercise may play a role in limiting disease development.
The relationship between density values of CD8+ And FOXP3+ as predictive factors for neoadjuvant folfox6 chemotherapy response in patients with locally advanced rectal cancer
Authors: Sugianto Anton , Lesmana Tomy , Danardono Edwin , Denny Septarendra Denny , Rahniayu Alphania
Published: January 2025

Introduction: Colorectal cancer ranks as the third most prevalent globally, with 1.9 million new cases and 900,000 deaths recorded. In Indonesia, 2020 witnessed 16,059 new rectal cancer cases, predominantly locally advanced rectal cancer (LARC) in those over 50. Annual incidents have risen by 2-8% in those under 50. Neoadjuvant therapy, particularly FOLFOX (folinic acid, fluorouracil, and oxaliplatin) or FOLFOX6 chemotherapy, is the primary treatment for LARC, aiming to downsize and downstage tumors. While previous studies explored overall TIL density, this research focuses on specific subsets (CD8+, CD4+, FOXP3+) crucial for neoadjuvant chemotherapy response. Examining CD8+, FOXP3+, and T-lymphocytes, this study aims to provide potent predictive markers for LARC patients undergoing neoadjuvant FOLFOX6 chemotherapy.
Methods: This is an observational analytic cross-sectional research design to establish the connection between the density of CD8+ and FOXP3+ regarding radiological response following neoadjuvant Folfox6 chemotherapy in patients with Locally Advanced Rectal Cancer.
Results: The study includes 60 subjects, with 53.3% showing positive chemotherapy response. The study reveals a significant association between high CD8 expression and positive chemotherapy response (p=0.02; OR=4). Additionally, a significant association is found between low FOXP3+ expression and positive chemotherapy response (p=0.01; OR=0.345). In subjects with positive chemotherapy response, 84.2% exhibit low CD8 and FOXP3+ expression, while 63.6% with high CD8 and low FOXP3 show positive response. High CD8 and FOXP3 expression in positive response is observed in 36.8%. No significant associations are found between CD8/FOXP3 combinations and response (p=0.06). No significant associations are observed between CD8/FOXP3 expression and tumor node metastasis (TNM) staging (p=0.608).
Conclusion: The study supports the hypothesis, indicating significant differences in chemotherapy response based on CD8+ and FOXP3+ expressions in locally advanced rectal cancer patients undergoing neoadjuvant FOLFOX6.
The role of urine Angiotensin-II (ANG-II) in predicting the occurrence of Acute Kidney Injury (AKI) induced by sepsis in children
Authors: Abdullah Arwini Avissa , Ganda Idham Jaya , Lawang St. Aizah
Published: January 2025

Link of Video Abstract: https://youtu.be/ml-58zJ21gM
 
Background: The incidence of AKI has increased by 2.8% per year. Sepsis is one of the main causes of AKI. Sepsis is a major cause of intensive care unit (ICU) mortality and morbidity in developing countries. ANG-II is an active peptide of the renin-angiotensin system (RAAS) that activates pro-inflammatory and pro-fibrotic pathways associated with the development of AKI. This study aims to identify the role of urinary angiotensin-II (ANG-II) in predicting the occurrence of acute renal impairment due to sepsis in children.
Methods: This study was an observational study with a prospective cohort approach. The population of this study were sepsis patients who initially did not experience AKI aged 1 month to 18 years who were hospitalized in the PICU with a total sample of 40 samples. Data were analyzed using SPSS version 25.0 for Windows.
Results: Based on the results of statistical tests using univariate tests, it was found that there was an association between ANG-II values and AKI in pediatric patients with sepsis, with higher values in children with AKI. Urinary Angiotensin-II value of 207.63 ng/ml is a predictor value of AKI in pediatric patients with sepsis with a sensitivity value of 76.7% and sensitivity of 70%.
Conclusion: This study concludes that urinary Angiotensin-II value can be used to predict the incidence of AKI in pediatric patients with sepsis.
Effectiveness of conditioned medium mesenchymal stem cells intracutaneous for trophic ulcer due to morbun hansen
Authors: Tan Sukmawati Tansil , Firmansyah Yohanes , Halim Kelvin Cristian , Aisyah Putri Bennya , Hendrawan Siufui
Published: January 2025

Link of Video Abstract: https://youtu.be/S9VOt1uCYlY
 
Introduction: The facts in the field that more than 50% of chronic ulcers, especially trophic ulcers due to leprosy fail to heal with usual treatment. Stem cell therapy or one of them is conditioned medium mesenchymal stem cell is a promising therapy because of its biological and physiological processes resembling the mechanism of wound healing
Methods: This research is a clinical trial research "Open Trial" Phase 2 to see the side effects caused by the intervention. Minimum sample size of 20 respondents with trophic ulcers due to leprosy that is difficult to resolve with usual treatment. The main outcome is wound healing in terms of the length and extent of the wound. The secondary outcome is treatment toxicity 4 weeks after administration. Follow-up visits will be scheduled at 2, 4, and 12 weeks post-treatment.
Results: 24 of 27 respondents successfully followed the study until the end. Prior to intracutaneously injecting CM MSC, the mean width, length, and area of tropical ulcers in patients with Morbus Hansen were 1.1 (0.3 - 12.0) cm, 2.0 (0.5 - 9.0) cm, and 2.38 (0.25 - 108) cm square, and after intracutaneously injecting CM MSC at the first follow up were 1.0 (0 - 4.5) cm, 1.5 (0 - 8.5) cm, and 1.0 (0 - 38.25) cm. The change between the start and finish of the intervention was statistically significant (p-value 0.05). Neither systemic nor local adverse effects were observed during or up to two months after the intervention.
Conclusion: The use of intracutaneous CM MSC injection has been proven effective in accelerating the process of wound healing, especially trophic ulcers due to leprosy with side effects that are not present in this study.
Perioperative factors of fast track extubation success following coronary artery bypass graft surgery: a literature review
Authors: Wiratama Siddiq , Sembiring Yan Efrata , Setiawan Philia
Published: January 2025

Introduction: Various studies have shown that fast-track cardiac care which its final aim is for early extubation after surgery, reduces hospital length of stays, cost, and post-operative morbidity rate. The main purpose of this study is to evaluate some perioperative factors as an independent predictor for a successful outcome for fast-track extubation (FTE) in patients undergoing coronary artery bypass graft surgery (CABG).
Method: This study analyzed multiple references using the keyword “Fast track Extubation”, “Perioperative Factors”, and “CABG”. Search engines such as PubMed, Google Scholar, ProQuest, and ClinicalKey were used to search for relevant papers from the last 15 years. We obtained total of 6 articles that meet our review criteria. We excluded some articles for not meeting our review methods considerations and by the year of publication that does not meet our standard.
 
Result: A total of 6 studies were identified regarding fast tract extubation post-CABG procedure. Numerous risk factor has been identified for successful of fast tract intubation after intubation such as post-operative bleeding, aortic cross-clamp time, cardio-pulmonary bypass time, chronic obstructive pulmonary disease, atrial fibrillation, ejection fraction pre-operative, diabetes mellitus, renal function, and patient age.
Conclusions: This study confirms that better perioperative profile such as age, good ejection fraction >40% has better chance for FTE success in patients undergoing CABG surgery.
Sensory analysis affective test and microbiological characteristics of the development formulation drink moringa date palm water extract
Authors: Yuliyana Triagung , Rimbawan Rimbawan , Damayanthi Evy , Palupi Eny , Iwansyah Ade Chandra
Published: January 2025

Link of Video Abstract: https://youtu.be/qiWALY9_ujU
 
Introduction: There is growing interest in the non-nutritional bioactive compounds present in food and beverages as possible "life nutrients" for preventing noncommunicable diseases. The dates moringa juice drink is a functional beverage that represents a rich source of bioactive compounds including carotenoids, phenolic acids, flavonoids, coumarins, alkaloids, polyacetylenes, saponins, and terpenoids. This study aimed to investigate the impact of incorporating various concentrations of moringa extract on the sensory quality and preference rating of date moringa juice.
Methods: The sample from the sensory test with the highest score were subsequently the color analysis was conducted using a chromameter, to perform the investigation, labels, iceboxes, mineral water, and questionnaires were used. The formulation procedure involved combining date palm juice (30%, 35%, 40%) in appropriate proportions with moringa extract.
Results: The statistical test's results for hedonic ratings revealed significant differences in dates moringa juice drink taste, aroma, and viscosity. The test also revealed that the dates moringa juice drink, Formula 1 with 30% added date palm juice, was the most favored in terms of taste of 6.38, aroma of 5.84, color of 6.23. The microbiological attributes total lactic acid bacteria (LAB) were 1.0 x 103 colonies/g, negativity for Salmonella, and an E. coli count 0 APM/g with a pH of 6.42 according to formula 1.
Conclusion: The most favored for water extracts of moringa and date palm treatment was the addition of 30% juice, which received a high preference rating from 35 panelists. F1 formula’s a higher mean score for six sensory attributes color, viscosity, aroma, taste, mouthfeel, and aftertaste. F1 formula’s a lower mean score for the microbiological attributes.
Pro and Anti-Inflammatory Factors in Patients with Rhegmatogenous Retinal Detachment with Silicone Oil Tamponade
Authors: Zulfiana Abidin Ahdini , Budu  , Ichsan Andi Muhammad , Muhiddin Habibah Setyawati , Eka Hasnah
Published: January 2025

Introduction: Rhegmatogenous retinal detachment (RRD) is the most common type of detachment, followed by exudative and tractional detachment. Pathogenic changes in the retina (including angiogenesis and fibrosis) trigger local inflammation and infiltration of leukocytes of the choroid, retina, and vitreous, which is also found in proliferative vitreoretinal detachment. Silicone oil, as a temporary tamponade used in the RRD, can cause immunological reactions in the tissue and may become one of the causes of increasing levels of inflammatory mediators in the eye. This literature review aims to determine the pro- and anti-inflammatory factors found in patients with RRD and patients with silicone oil tamponade.
Methods: This literature review utilised reliable databases such as Pubmed, Proquest, and Google Scholar from 2013 until 2023. The main keywords “rhegmatogenous retinal detachment” and “silicone oil” were used, including some additional keywords, to collect eight journals that had relevant topics.
Result: Variations of inflammatory markers were found in many studies, and some correlated with proliferative vitreoretinopathy (PVR) development, the extent of detachment and the recurrence of redetachment in some cases.
Conclusion: A rise in various cytokines can mediate the wound-healing process in RRD, specifically involving retinal pigment epithelium and glial cells, fibroblasts, and inflammatory cells in eyes with retinal tears. This trend of high activity of RPE cells also appeared in eyes with vitreous cavities replaced by silicone oil (SO). The selection of tamponade preference should be based on the extent of the injury, patients’ needs, and surgeons’ expertise.