bluuebunny/crossref_metadata_2025 huggingface dataset:
Closed Loop Control of DSMST Converter for Ev Applications
Authors: Jeetender Vemula Et al.
Published: January 2024

Transformerless step-down and step-up DC-DC topologies are currently extensively employed in a variety of applications. A positive output voltage SEPIC-type DC-DC converter without a transformer is proposed in this article. This configuration has the benefit of input continuous current over the traditional buck-boost converter, making it better suited for use with electric vehicles. Moreover, it has an increase in gain that is quadratic of the voltage gain of a standard topology. Also, the suggested converter has a constant current output, which decreases the output voltage ripple and reduces the current stress on the converter's output capacitor. As a result, this converter can generate an extensive range of voltages with less input and output ripples. In addition, closed loop control of DSMST converter is presented in the paper using PI control Ziegler- Nichols method. In the end, simulation findings are shown to support the converter's closed loop  study.
Transforming Talent Management: The Journey to E-Human Resources Excellence
Authors: Tuli Ferdouse Ara
Published: January 2024

This study offers a comprehensive exploration of the dynamic evolution within human resources (HR) and the transformative journey of talent management in the digital era. Beginning with an examination of foundational talent management principles, the narrative traces the shift from traditional HR frameworks to the contemporary landscape of E-Human Resources (E-HR) excellence. The study emphasizes the role of digital technologies as catalysts for this evolution, showcasing their impact on optimizing recruitment, performance management, and employee engagement. Throughout, HR innovation emerges as a driving force, highlighting how novel approaches and technologies are reshaping the HR landscape. This initiative underscores the pursuit of excellence in talent management within the E-HR paradigm, outlining strategies and best practices for organizations to navigate and thrive in the complexities of the modern workforce. In essence, this exploration encapsulates the ongoing narrative of innovation and excellence in the transformative journey of talent management within the digital era, providing valuable insights for HR professionals, organizational leaders, and policymakers navigating the evolving HR landscape.
Further Development of the Lower Cretaceous Clinoform Model of the North of West Siberia Based on the Sequence Stratigraphy Principles: New Possibilities of Stratification
Authors: Lebedev Mikhail V. , Astafyev Evgeniy V. , Khramtsova Alena V.
Published: January 2024

The clinoform concept of the Lower Cretaceous of Western Siberia was and remains the scientific basis for predicting its oil and gas potential. At the same time, new challenges and new technological opportunities require its further development. The basis for this can be a modern model independent methodology of sequence stratigraphy, the essence of which is to divide the stratigraphic section into a succession of systems tracts by mapping of all sequence stratigraphic surfaces. At the same time, the choice of the type of surfaces limiting the sequence is carried out already at the second stage on the basis of the expression of the surfaces in the stratigraphic section or the preferences of the researcher.
The wide development of unconformities in the Western Siberian Lower Cretaceous clinoform complex makes it possible to subdivide clinoforms into four systemic tracts: highstand HST, falling-stages FSST, lowstand LST, transgressive TST. The subdivision is carried out by mapping sequence stratigraphic surfaces based on the analysis of stratal stacking patterns. According to the authors, the boundaries of the sequences in this case should be the tops of the TST – the downlap surfaces (DLS), traditionally interpreted as maximum flooding surfaces (MFS). This ensures the consistency of the proposed approach with the clinoform concept.
The named clinoforms of Western Siberia can be considered as genetic sequences of the III order. However, the position of facies in their systems tracts is far from always predictable. For further detailing of facies models, clinoforms – III order sequences should be subdivided into clinoforms – IV order sequences, and subdivide them into systems tracts. But the latter are not always mapped by modern seismic method. Special conditions are necessary for this. Therefore, it is proposed at first to subdivide the III order sequences into systems tracts. Then – to map their thicknesses, and to allocate of their depocenters. Further, within the depocenters (under suitable seismogeological conditions), to define IV-order clinoforms – sequences and their constituent system tracts as a basis for mapping reservoirs and hydrocarbons traps.
Evolution of the composition of Н, О and C stable isotopes in the groundwaters of oil and gas bearing sediments in the northern regions of West Siberia
Authors: Novikov Dmitry A. , Pyrayev Aleksandr N. , Maksimova Anastasia A. , Dultsev Fedor F. , Chernykh Anatoly V.
Published: January 2024

The results of a study of the isotopic composition of oxygen and hydrogen of groundwater and dissolved inorganic carbon in oil and gas deposits of the northern regions of Western Siberia, covering a wide stratigraphic range – Mesozoic and Paleozoic are presented. The obtained values are very diverse, covering the intervals from –120 to –50‰ (δD) and from –17 to –2‰ (δ18O). Such a variable isotopic composition of waters indicates the absence of a unified mechanism for the accumulation of waters and their transformation during the geological evolution of the West Siberian sedimentary basin. The main feature of most of the studied waters is the pronounced values of oxygen isotope shifts relative to GMWL, which generally increase with the age of water-bearing deposits and reach 9‰, which indicates their ancient sedimentary origin.
Variations in the isotopic composition of DIC (from –51.8 to +21.8‰) and its content in waters (from 0.2 to 38.6 mmol/I) indicate a wide range of water burial conditions and processes involved in the conversion of water-soluble carbon dioxide. A general pattern of changes in the isotopic composition of carbon in CO2 with time, expressed in general form by damped oscillations of the “isotope oscillator”, is revealed. A model of transformation of the carbon isotope composition in carbon dioxide in the closed cycle “atmosphere-soils-deep aquifers” for oil and gas deposits of the northern regions of Western Siberia based on the obtained isotope data is proposed.
Integration of petroleum geology methods for oil and gas exploration
Authors: Polyakov Andrey A. , Stoupakova Antonina V. , Malyshev Nikolay A. , Sautkin Roman S. , Verzhbitsky Vladimir E. , Komissarov Dmitry K. , Osipov Sergey V.
Published: January 2024

Integration of petroleum geology methods is the process of applying results of several methods for solving a task or group of tasks in order to reduce the limits of uncertainties in its solution. Since in the oil and gas industry there are a large number of methods, often aimed at solving similar problems, it is necessary to reduce the number of methods solving the same tasks. Thus, the integration of petroleum geology methods means the creation of exploration structures and algorithms for prediction of oil and gas contents. The system can be used not only to select a rational complex of exploration methods, but also to predict petroleum potential in the area by different methods, including IT technologies.
3D modeling of salt domes according to detailed drilling data in the Precaspian region
Authors: Lapkovsky Vladimir V. , Lunev Boris V. , Antipov Mikhail P. , Volozh Yuri A. , Pisarenko Yuri A. , Fomina Valeria V.
Published: January 2024

To create three-dimensional models of arcomorph structures based on detailed data of drilling without involving genetic considerations and indirect information, the potential fields method is effective, which consists of finding an approximating three-dimensional function, the set of isolevel surfaces of which are identified with stratigraphic boundaries, using the coordinates of the formation intersection points. For approximation, mainly three-dimensional splines expressed in terms of Green’s functions were used. The main difficulties are associated with the presence of structural unconformities, to take into account which the initial data, and the models built on their basis, are subjected to special spatial transformations. To avoid the influence of high-amplitude arcomorphs on the geometry of the layers of the pre-salt complex, the modeling of the latter was carried out separately from the intensely deformed evaporates and overlying layers. Assaying of the method was carried out at one of the sites in the Caspian Sea. On the study area, according to the interpretation of logging data from 249 wells, a three-dimensional model was created, including several arcomorph structures, and covering the stratigraphic interval from the Emsian stage of the Lower Devonian to Quaternary deposits. The results confirmed the presence of arcomorphs with overturned beds. Such structural forms are poorly fixed by 2D–3D seismic survey methods. The proposed method can be applied in geological studies in the search and exploration of hydrocarbons in salt dome areas.
Catagenetic trends in composition and structure parameters of asphaltenes
Authors: Borisova Lyubov S. , Timoshina Irina D.
Published: January 2024

Сatagenetic transformations of asphaltenes of organic matter (OM) from recent sediments and fossil rocks were studied on rocks sampled from different sedimentary basins (Timan-Pechora, Mezen, West Siberian, Kuznetsk, Aldan-Maya and Middle Amur) of Russia. Changes in the elemental composition of asphaltenes were analyzed with the Veselovsky’s model of the formation of major groups of fossil fuels using cO parameter (cO = (O/8 – N)/(C/3)) as compared with the total carbon based on elemental analysis. Just as the Van-Krevelen diagram, the plot built in C–cO coordinates for OM of various genetic forms demonstrates a significant difference in the asphaltenes composition evolution during catagenesis. At the same time, the cO parameter has notably increased in asphaltenes of both types of OM. Structural transformations of asphaltenes during catagenesis were identified in the course of high-resolution NMR (nuclear magnetic resonance) spectroscopy. The research results comprise data on carbon distributions in the aromatic and aliphatic groups in the investigated asphaltenes of different type OM of sediments and rocks at different stages of lithogenesis. A correlation between the asphaltene composition and structural parameters depending on thermocatalytic transformations is revealed. The asphaltenes of terrestrial organic matter are distinguished by higher cO values and different carbon yields of aromatics (higher) and aliphatics (lower) throughout the catagenesis phase. The highly transformed marine OM is marked by surge condensation of aromatic rings in asphaltenes, which makes them similar to asphaltenes of the terrestrial type OM.
Lithology and oil content of the Bazhenov Formation in the central part of the Mansi Syneclise (Russia)
Authors: Fomin Mikhail A. , Saitov Rashid M. , Zamirailova Alvina G.
Published: January 2024

The article presents the results of studying four sections of the Bazhenov Formation and the overlying sediments in the central part of the Mansi syneclise, which are based on a comprehensive analysis of the results laboratory lithological and geochemical studies of core material and data from a wide range of geophysical studies of wells. For lithological characteristics, the section of the Bazhenov Formation was divided into five members, which differ in the ratio of carbonaceous, clayey, siliceous contents and carbonate component of rocks. The boundaries of the units were determined by their lithological composition, and then the velocity rectified taking into account GIS. The first two members are characterized by high contents of siliceous and clayey material, the third – a significant increase in the siliceous component, the fourth – increased concentrations of organic matter, which indicates its higher compared to the lower part section oil generation potential. In the fifth member, the content of carbonate material increases, the “coccolithic” interval is divided, and numerous fragments of bivalves are noted. Throughout the section minerals (strontianite, witherite) were discovered in the Bazhenov Formation, indicating that they occurred in diagenesis hydrothermal processes.
In the section of one of the studied wells in the middle part of the Bazhenov formation, a reservoir interval was identified. High variability of reservoir properties of Bazhenov rocks was noted even within one oil-field, which is associated with their secondary transformations of rocks in dia- and catagenesis. It is substantiated, that materials of geophysical studies of wells that does not contain nuclear magnetic resonance data can only be used to identify possible productive intervals, the study of which by laboratory methods will allow establish the presence or absence of collectors in them.
Using a model of zonal drainage of an artificial gas deposit for analytical control of gas volumes in reservoirs of UGS
Authors: Mikhailovsky Alexander A. , Ukolov Anton V.
Published: January 2024

One of the main tasks of the analysis of gas storage in aquifers-reservoirs is the operational control of drained volumes of gas, the value of which largely depends on the technological and technical and economic indicators of the creation and operation of UGS. An effective tool for solving this problem is the use of gas-hydrodynamic proxy models of formations.
One of such models is presented, which, taking into account the implemented system of group (by assembly points) placement of vertical production wells, can be briefly described as a model of zonal drainage and seasonal interzonal gas flows in the reservoir.
An example of calculations of changes in the cyclic operation of UGS of gas-saturated pore volumes and gas volumes in different drained zones, including in the peripheral poorly controlled zone of the formation, taking into account seasonal interzonal gas flows, as well as the volumes of man-made gas accumulations in the control horizons formed as a result of interplastic flows is given.
Tathbiiq Wasilah al-Ta’liim Puzzle Envelope fi Ta’allum al-Lughoh al-Arabiyyah li Thullab Madrasah Budi Mulia al-Mutawassithoh al-Tsaaniyah Yogyakarta
Authors: Rahmawati Fitra Awalia , Amaliza Fhira Rukti
Published: January 2024

المدرسة الثانوية بودي موليا دوا هي المدرسة الإسلامية التي يستخدم اللغتين الإندونيسية والإنجليزية في التعليم، وهي إحدى المدارس العالمية في إندونيسيا. ولها مجموعة متنوعة من المواد الدراسة، ولكن تعليم اللغة العربية في هذه المدرسة بدأ في عام 2022، ولم توجد استراتيجية أي طريقة التعليم المشوقة لتعليم اللغة العربية. بسبب هذه المشكلة، يحصل بعض الطلاب عدم اهتمام عند عملية التعلم بالنظر على النتائج أقل من النتائج المعدل. لذلك حاولت الباحثة تقديم وسيلة تعليم لغز المغلف التي يمكن أن تجعل الطلاب أكثر اهتمامًا وتسهل على الطلاب فهم تعلم اللغة العربية وتشجّع المدرسة في تطبيق طرق التعلم المبتكرة. مؤسسا على المشكلات السابقة يهدف هذا البحث إلى معرفة فعالية تطبيق وسيلة التعليم لغز المغلف على نتائج تعلم اللغة العربية لطلاب الصف الثامن بالمدرسة بودي موليا دوا يوجياكارتا 2022-2023.  إن نوع البحث المستخدم في هذا البحث هو بحث كمي تجريبي، وأخذت الباحثة بنوع تصميمه على شكل التجربة الحقيقة ومنهج الفرقة المنظمة حيث يتم أخد اختيار أعضاء الفصل التجريبي والفصل الضابط بشكل عشوائي. وطريقة جمع البيانات المستخدمة في هذا البحث هي المقابلات والاختبارات والتوثيق. ويتم إجراء تحليل البيانات باستخدام اختبار غير بارمترا بالاختبار الطبيعي والاختبار التجانس والاختبار الفرضي Mann Whitney ببرنامج SPSS 22 لأن البيانات غير طبيعية. من خلال هذا البحث، استنتجت الباحثة أن تنفيذ وسيلة التعليم لغز المغلف في تعليم اللغة العربية وهي 0.000 كانت أصغر من 0.05. فاستنتجت الباحثة أن H0 مرفوض وHaمقبول، من هذه المعلومات تتبين لنا بأن هناك فرق بين نتائج تعلم اللغة العربية في الفصل التجريبي والفصل الضابط. من هذه النتائج، استنتج أن وسيلة التعليم لغز المغلف كانت فعالة في نتائج تعلم اللغة العربية لطلاب الصف الثامن بالمدرسة الثانوية بودي موليا دُوا يوجياكارتا 2022-2023.
The Effectiveness of Song Translation In Increasing Vocabulary To Develop Speaking Skills At SDN 1 Paciran
Authors: Fikri Shofil , Al-Furqaan Dimas Luqman
Published: January 2024

Translation theory is all choices and decisions based on the experiences of each translator, which are subjective and result from a training process. So, in this study the authors aimed to test the effectiveness of the song translation method in increasing vocabulary to develop speaking skills in students of SDN 1 Paciran. This research is included in the type of quantitative research. And based on data collection techniques, this research is classified as experimental research, namely pre-experimental design by comparing one group pre-test and post-test. The song used is the song Los Dol Deny Cak Nan whose lyrics have been translated into Arabic. The data obtained were then analyzed using quantitative descriptive techniques with the help of IBM SPSS Statistics 26, so that researchers could find out how much influence the translation of songs had with the t-test. The results of this study indicate that translating songs in increasing vocabulary is very effective for developing the speaking skills of SDN 1 Paciran students, this is evidenced by the results of the paired sample test where sig. (2-tailed) shows the number 0.002.
From Hysteria to Functional Neurological Symptom Disorder: Developments in Clinical Diagnosis and Neurobiology
Authors: BAĞCAZ Arda , CERAN Selvi
Published: January 2024

Changes in the nomenclature of functional neurological symptom disorders (FND) from the past to the present represent historical changes in understanding etiology. Today, there is still difficulty in excluding potential underlying neurological disorders. In addition, there is no consensus on the psychological mechanism leading to the disorder. As a result, diagnostic problems continue to exist. While functional neuroimaging studies show that suppression and conversion mechanisms, which are the concepts of the psychoanalytical theory, may have neural counterparts, neurobiological data suggests that the conversion model cannot be explanatory for every patient. The dorsolateral prefrontal cortex (dlPFC), amygdala, temporoparietal junction (TPJ), insula, anterior cingulate structures, and their connections come to the fore. The fact that the connections between the dlPFC and the hippocampus can prevent the recall of an unwanted memory, as well as the changes detected in the amygdala in these disorders and the increased connectivity between the amygdala and the motor areas, suggest an abnormal connection between emotions and the motor system. It is addressed how changes in the TPJ are related to the loss of the sense of agency. However, it is unclear whether the findings of these studies suggest a "predisposition", "onset of disorder", or "compensatory changes secondary to disorder". Exploring FND to learn how the brain and mind react to psychosocial stressors can be a turning point in understanding the brain-mind connection. The goal of this review is to present the history of the changes in terminology and perspective on this disorder that followed the establishment of psychoanalysis, as well as what kind of evidence has been presented regarding hysteria in light of advances in neuroscience
OPTIMALISASI SISTEM PEMELIHARAAN PADA GEDUNG SEKOLAH BERBASIS PENGGUNA GEDUNG (Studi Kasus SMA Negeri 2 Meulaboh)
Authors: Rita Fazlina  , David Setiawan  , Rinaldy  , Veranita  , Astiah Amir  , Raina Parmitalia Dinda  , Zulyaden
Published: January 2024

Dalam upaya menjaga kondisi bangunan sekolah agar tetap dalam keadaan baik maka perlu dilakukan pemeliharaan secara rutin. Tujuan penelitian ini adalah untuk mengetahui tingkat partisipasi pengguna gedung SMAN 2 Meulaboh terhadap pemeliharaan rutin. Penelitian ini menggunakan penelitian kualitatif deskriptif. Pengumpulan data primer diperoleh dengan cara observasi, wawancara, dokumentasi, dan penyebaran kuesioner, sedangkan data sekunder diperoleh dari instansi atau lembaga terkait. Analisis data diolah dengan menggunakan metode Skala Likert. Teknik pengambilan sampel yang digunakan adalah Proportionate Stratified Random Sampling. Hasil analisis yang diperoleh adalah 81 siswa (95,294%) berada pada kategori partisipasi sedang, 4 siswa (4,706%) berada pada kategori partisipasi tinggi, 21 orang guru (70%) berada pada kategori partisipasi sedang, 9 orang guru (30%) %) masuk dalam kategori partisipasi tinggi, untuk 9 orang staf sekolah dan 1 orang penjaga sekolah, hasil yang diperoleh adalah 6 responden (60%) masuk dalam kategori partisipasi sedang, 4 responden (40%) masuk dalam kategori partisipasi tinggi, dan tidak ada satupun orang yang masuk dalam kategori partisipasi tinggi. responden berada pada kategori partisipasi rendah. Kesimpulannya menunjukkan bahwa pengguna bangunan SMAN 2 Meulaboh berpartisipasi dalam pemeliharaan gedung sekolah dan menunjukkan bahwa pengguna bangunan dominan berada pada kategori partisipasi sedang, sehingga diperlukan kerjasama semua pihak untuk mencapai tingkat partisipasi yang tinggi.
The impact of perceived integrity of government agencies on trust in the police and the mediating effect of trust in government agencies
Authors:   Korean Association of Public Safety and Criminal Justice, Kim So Yeong , Jung Bo Sung
Published: January 2024

Looking at previous studies on factors affecting trust in police in Korea, we can see that most of them are limited to variables related to police activities (fairness, effectiveness, etc.). However, the police is one of the government agencies under the Ministry of Public Administration and Security, and improving police activities or citizens' awareness of police activities alone may not be enough to increase trust in the police. Previous overseas studies have gone further to identify factors influencing trust in the police through comparative studies using country-level variables. The purpose of this study is to determine the impact of citizens' perception of the integrity of government agencies on trust in the police and to verify the mediating effect of trust in government agencies in that influence relationship. Accordingly, the Korea Institute of Public Administration conducted a quantitative statistical analysis based on the results of a survey collected as part of the 2021 “Study on Governance and the Level of Trust in Korean Society.” As a result of the analysis, trust in government agencies was found to have a significant partial mediating effect between the integrity of government agencies and trust in the police. These research results suggest that there is a need to more broadly discuss improving trust in the police in order to elicit police cooperation as an essential element of community police activities, which is the basis of the modern police activity paradigm. Therefore, in follow-up research, related influencing factors should be explored through a review of overseas previous research, and scale development and validation work to apply it domestically should be prioritized.
Planlı Gelişme Alanlarının Hava Kirliliğine Olası Etkilerinin Değerlendirilmesi
Authors: ARSLAN Merve , DURSUN Doğan
Published: January 2024

Bu çalışmada yeni gelişme alanlarındaki imar planı kararlarının hava kirliliği üzerindeki etkisini önceden tespit etmek amaçlanmıştır. Bu amaçla Erzurum kentinin yerleşik alanı için mevcut (2021) hava kirliliği analizi üretildikten sonra, çalışma alanı içerisinde önerilen uygulama imar plan kararları doğrultusunda 2027 hedef yılı için yeni bir hava kirliliği analizi üretilmiştir. Burada imar plan kararlarıyla değişecek olan kentsel dokunun nasıl bir etki yaratacağının belirlenmesi amaçlanmıştır. Çalışmada yöntem olarak ağırlıklı çakıştırma analizi kullanılmıştır. Analiz dört temel veri grubu üzerinden yürütülmüştür. Topografik veri grubu içerisinde yükselti analizi, meteoroloji veri grubu içerisinde sıcaklık analizi, hava kirliliği verileri içerisinde PM10-SO2 analizleri ve plan kararları veri grubu içerisinde yeşil alanlar, kat yüksekliği, nüfus yoğunluğu, sanayi alanları ve yapay yüzey analizleri kullanılmıştır. Belirlenen her kriter için alt kriterler oluşturulmuş ve kriter için bir etki derecesi ile her alt kriter için bir ağırlık puanı belirlenmiştir. Analizler NetCAD ve ArcGIS programları kullanılarak elde edilmiştir. Yürütülen çalışma sonucunda elde edilen bulgular, kat yüksekliğinin, nüfus yoğunluğunun, yapay yüzey oranının fazla olduğu alanlarda hava kirliliğinin yoğunlaştığını göstermiştir. Bununla birlikte yeşil alan miktarının fazla, yapay yüzey oranının az olduğu alanlarda hava kirliliği yoğunluğunun daha az olduğu tespit edilmiştir. Analizlerde kentin sıcaklık durumu ve topografik yapısının da hava kirliliği üzerinde olumsuz etkiler yarattığı sonucuna ulaşılmıştır.
Study on the effect of rolling mill dynamic stiffness on coupled vibration of hydraulic machine
Authors: Wang Lidong , Hou Peng , Wang Shen , Wang Chengzhen , Yan Xiaoqiang , Wang Xiaoling
Published: January 2024

The productivity and capacity release of hot-strip rolling is severely limited by pendular vibration. Previous studies on mill vibration have investigated the influence of rolling parameters on vertical vibration; however, the influence of dynamic stiffness compensation factors on vertical vibration has not yet been considered owing to the limitations of modelling methods. Herein, we develop a simulation model of mill liquid–machine coupling with dynamic stiffness compensation using AMESim software. The established simulation model is used to investigate the effect of this dynamic stiffness compensation on mill vertical vibration under conditions of downfeed thickness difference excitation frequency, thickness difference excitation amplitude, thickness difference excitation phase, and dynamic stiffness compensation signal generation hysteresis. Evidently, the impact of the mill stiffness compensation on the mill vertical vibration differs with the thickness of the excitation frequency, and the impact should be discussed according to the excitation frequency segment. The amplitudes of the roll system vibration and incoming thickness difference excitation are essentially linear, whereas the excitation phase does not affect the frequency or amplitude of the mill vibration. The rolling machine stiffness compensation signal hysteresis also has a significant impact on the mill vibration amplitude. Our findings will improve the mechanism of the hot rolling process and suppress droop vibrations.
Updated Intrinsic Role of Phytochemicals against Glyphosate-induced
Neurotoxicity: Systematic Review
Authors: Fan Ruitai , Zheng Yufei , YN Lakshmi Durga , Beeraka Narasimha M , Vikram P R Hemanth , Suhail Shaik Mohammed , Manjula Santhepete N. , Bannimath Namitha , Sinelnikov Mikhail Y , Liu Junqi
Published: January 2024

Background:

Glyphosate-based herbicide (GBH) formulations are
organophosphorus pesticides implicated for agricultural use. Several epidemiological reports
have reported that the occupational exposure of farmers to glyphosate can cause
age-related neurodegeneration.

Objective:

the objective of this study is to examine the neurotoxic effects of glyphosate
and its intricate role in triggering several neurodegenerative diseases like dementia,
nootropic defects, Parkinson’s disease, and neurological teratogenic effects due to its
negative effects on the nervous system. Furthermore, the efficacy of phytochemicals
against glyphosate-induced neurotoxicity was discussed.

Methods:

We have searched public databases such as NLM, Pubmed, google scholar
and collected a total of 103 articles including reviews, original articles, and obtained information
related to glyphosate-induced neurotoxicity and novel phytochemicals implicated
to ameliorate the glyphosate-induced neurotoxicity. We performed a systematic review
without comprehensive meta-analysis.

Results:

the efficacy of several phytochemicals as a nutritional intervention against
glyphosate-induced neurotoxicity including Parkinsonism was elucidated by vivid review
analysis of neurobehavioral alterations from in vitro and in vivo study models.

Conclusion:

These kinds of research projects will bring awareness about the neurotoxic
effects of glyphosate and the protective nutritional intervention strategies against
glyphosate-induced neurotoxicity including Parkinsonism for farmers.
Current Understanding of Androgen Signaling in Prostatitis and its
Treatment: A Review
Authors: Cabeza Marisa
Published: January 2024

Chronic prostatitis is a highly prevalent condition that significantly impacts
the quality of life and fertility of men. Because of its heterogeneous nature, there is no
definitive treatment, which requires ongoing research into its etiology. Additionally, the
association between prostatitis and an elevated risk of prostate cancer highlights the importance
of comprehending androgen involvement in prostatitis. This paper examines
the current understanding of androgen signaling in prostatitis and explores contemporary
therapeutic approaches. It was reviewed Medline articles comprehensively, using
keywords such as nonbacterial prostatitis, prostatitis infertility, androgen role in prostatitis,
and chronic pelvic pain. Several cellular targets are linked to androgen signaling.
Notably, the major tyrosine phosphatase activity (cPAcP) in normal human prostate is influenced
by androgen signaling, and its serum levels inversely correlate with prostate
cancer progression. Androgens also regulate membrane-associated zinc and pyruvate
transporters transduction in prostate cells, suggesting promising avenues for novel drug
development aimed at inhibiting these molecules to reduce cancer tumor growth. Various
therapies for prostatitis have been evaluated, including antibiotics, anti-inflammatory
medications (including bioflavonoids), neuromodulators, alpha-blockers, 5α-reductase
inhibitors, and androgen receptor antagonists. These therapies have demonstrated
varying degrees of success in ameliorating symptoms.In conclusion, aging decreases circulating
T and intraprostatic DHT, altering the proper functioning of the prostate, reducing
the ability of androgens to maintain normal Zn2+ levels, and diminishing the secretion
of citrate, PAcP, and other proteins into the prostatic fluid. The Zn2+-transporter decreases
or is absent in prostate cancer, so the pyruvate transporter activates. Consequently,
the cell ATP increases, inducing tumor growth.
Network Pharmacology Analysis and In Vitro Validation of the Active Ingredients and Potential Mechanisms of Gynostemma Pentaphyllum Against Esophageal Cancer
Authors: Guo Jianxin , Wu Zhongbing , Chang Xiaoyue , Huang Ming , Wang Yu , Liu Renping , Li Jing
Published: January 2024

Background:

Esophageal cancer (EC) is one of the deadliest malignancies worldwide.
Gynostemma pentaphyllum Thunb. Makino (GpM) has been used in traditional Chinese medicine
as a treatment for tumors and hyperlipidemia. Nevertheless, the active components and underlying
mechanisms of anti-EC effects of GpM remain elusive.

Objective:

This study aims to determine the major active ingredients of GpM in the treatment of
EC and to explore their molecular mechanisms by using network pharmacology, molecular docking,
and in vitro experiments.

Methods:

Firstly, active ingredients and potential targets of GpM, as well as targets of EC, were
screened in relevant databases to construct a compound-target network and a protein-protein interaction
(PPI) network that narrowed down the pool of ingredients and targets. This was followed
by gene ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway enrichment analyses. Next, molecular docking, ADME and toxicity risk prediction,
cell viability assays, in vitro scratch assays, Transwell cell invasion assays, and Western
blotting analysis were subsequently applied to validate the results of the network analysis.

Results:

The screening produced a total of 21 active ingredients and 167 ingredient-related targets
for GpM, along with 2653 targets for EC. The PPI network analysis highlighted three targets
of interest, namely AKT1, TP53, and VEGFA, and the compound-target network identified three
possible active ingredients: quercetin, rhamnazin, and isofucosterol. GO and EKGG indicated
that the mechanism of action might be related to the PI3K/AKT signaling pathway as well as the
regulation of cell motility and cell migration. Molecular docking and pharmacokinetic analyses
suggest that quercetin and isoprostanoid sterols may have therapeutic value and safety for EC.
The in vitro experiments confirmed that GpM can inhibit EC cell proliferation, migration, and
invasion and suppress PI3K and AKT phosphorylation.

Conclusion:

Our findings indicate that GpM exerts its anti-tumor effect on EC by inhibiting EC
cell migration and invasion via downregulation of the PI3K/AKT signaling pathway. Hence, we
have reason to believe that GpM could be a promising candidate for the treatment of EC.
Potential Role of Oxidative Stress in the Pathophysiology of Neurodegenerative Disorders
Authors: Singh Sonia , Ahuja Ashima , Pathak Shilpi
Published: January 2024

Neurodegeneration causes premature death in the peripheral and central nervous system.
Neurodegeneration leads to the accumulation of oxidative stress, inflammatory responses,
and the generation of free radicals responsible for nervous disorders like amyotrophic lateral
sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disorders. Therefore, focus
must be diverted towards treating and managing these disorders, as it is very challenging. Furthermore,
effective therapies are also lacking, so the growing interest of the global market must
be inclined towards developing newer therapeutic approaches that can intercept the progression
of neurodegeneration. Emerging evidences of research findings suggest that antioxidant therapy
has significant potential in modulating disease phenotypes. This makes them promising candidates
for further investigation. This review focuses on the role of oxidative stress and reactive
oxygen species in the pathological mechanisms of various neurodegenerative diseases, amyotrophic
lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disorders and
their neuroprotection. Additionally, it highlights the potential of antioxidant-based therapeutics
in mitigating disease severity in humans and improving patient compliance. Ongoing extensive
global research further sheds light on exploring new therapeutic targets for a deeper understanding
of disease mechanisms in the field of medicine and biology targeting neurogenerative disorders.
Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8
Nanoparticles
Authors: Shahidi Fatemeh , Naimi-Jamal M. Reza , Habibi Azizollah , Dekamin Mohammad G.
Published: January 2024

Introduction:

Zeolitic imidazolate frameworks (ZIFs) play a crucial role among metalorganic
frameworks due to their highly desirable properties, including high surface area, appropriate
pore size, and excellent thermal and chemical stability.

Method:

In this study, ZIF-8 loaded with aspirin and coated using pectin (ZIF-8/Asp@Pectin) was
utilized as a suitable and effective platform for the drug delivery system. The preparation of this
coated MOF followed environmentally friendly methods, and aspirin was successfully loaded.

Result:

Characterization of the obtained ZIF-8/Asp@Pectin was performed using X-ray diffraction
(XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), Fourier Transform
Infrared (FT-IR) spectroscopy, and BET analysis.

Conclusion:

The release of aspirin from ZIF-8/Asp@Pectin was studied using UV–Vis spectroscopy
at 258 nm under in vitro conditions in HCl and PBS buffer solutions.
One Pot Synthesis of New Benzimidazole Derivatives with Exceptionally
High Luminescence Quantum Efficiency
Authors: Mensah Abraham , Liu Xin-Ye , Hu Bing-Xiang , Kweku Ennin Vendish , Wang Fang-Ming , Chen Li-Zhuang , Zheng Shao-Jun
Published: January 2024

Aim and Objectives:

There are different approaches to the synthesis of benzimidazole. In this article, five new benzimidazole derivatives, BMPO, Me-BMPO, Di-MeBMPO, F-BMPO and Cl-BMPO where (BMPO=3-[(1H)-benzo[d]imidazol-2-yl]pyridin-2(1H)-one), have been prepared. Another study was carried out on luminescence properties and their potential applica-tions for the detection of transition metal ions.

Materials and Methods:

From the one-pot synthesis approach, all the derivatives of the benzim-idazole compounds were obtained. The compounds were characterized using HRMS, 1HNMR, 13CNMR, and X-ray crystallography. Herein, a mechanism has been deciphered by predicting the release of HCl(g).

Results:

All compounds showed a strong deep blue emission when dissolved in dimethylacetamide (DMA), with emission wavelengths at 423, 428, 435, 423, and 421 nm, and half-times of 3.64, 2.77, 2, 19, 3.42 and 3.52 ns, respectively. In addition, their emission quantum yields were deter-mined to be 72, 50, 42, 73 and 80%.

Conclusion:

Five new benzimidazole derivatives, BMPO, Me-BMPO, Di-MeBIPO, F-BIPO, and Cl-BIPO, have been successfully synthesized by the one-pot synthesis method, and their struc-tures are characterized and confirmed. The compounds exhibited exceptional luminescence by emitting a strong blue light in DMA with high fluorescence quantum yields between 42~80%.
Unifying Theory and Experiments: Multi-Target Pharmacology of Dajihan Pill Against Hyperlipidemia
Authors: Li Ning , Bian Canfeng , Gao Ya , Liu Lingfei , Hu Qin , Xiao Lixia , Guan Tianzhu
Published: January 2024

Background:

The increasing incidence of hyperlipidemia (HLP) is attributed to the imbalance
in redox homeostasis, aberrant lipid metabolism, and the excessive intake of empty calories.
Dajihan Pill (DJHP) is a Traditional Chinese Medicine (TCM) formula composed of Zingiberis Rhizoma
(ZR), Piperis Longi Fructus (PLF), Alpiniae Officinarum Rhizome (AOR), and Cinnamomi
Cortex (CC) in a ratio of 3:2:3:2. It exhibits a significant preventive effect on HLP. Certainly, the
active components and the precise mechanism of action are not fully understood. Therefore, this
study aims to elucidate the preventive and ameliorative mechanisms of DJHP against HLP by integrating
network pharmacology, molecular docking, and experimental validation.

Methods:

Based on the pharmacological method, active ingredients in DJHP and targets were extracted
from Traditional Chinese Medicine System Pharmacology (TCMSP) and UniProt. Then core
compounds and targets were obtained by constructing “compounds-targets-disease” and proteinprotein
interaction (PPI) network. Gene Ontology (GO) function analysis and Kyoto Encyclopedia of
Genes and Genomes (KEGG) were employed to elucidate further the associated action mechanism.
The molecular binding mechanisms between the core ingredients and targets were elucidated through
molecular docking. Additionally, the antioxidant capacities of DJHP extracts were investigated by
assessing their DPPH, hydroxyl, and ABTS radical scavenging activities.

Results:

A total of 45 active compounds and 258 targets were identified in DJHP. Network analysis
indicated that quercetin, beta-sitosterol, kaempferol, and oleic acid might serve as core bioactive
compounds. Seven core targets, including AKT1, INS, and TNF, were identified as potential preventive
targets. GO analysis suggested the improvement of HLP by DJHP may be related to the lipid
metabolic process, high-density lipoprotein particle, triglyceride binding, and inflammatory response.
The KEGG analysis indicated TNF, HIF-1, and AMPK signaling pathways were involved.
The observations of active compounds binding with core targets indicated an excellent combination.
Additionally, antioxidant results showed that DJHP exhibited significant DPPH, hydroxyl, and
ABTS radical scavenging activities.

Conclusion:

Theoretical and experimental investigations indicate that DJHP can effectively modulate
various signaling pathways and enhance the redox system, thus mitigating HLP. Our work provided
a basis for the pharmacological study of DJHP in preventing HLP and further research.
The Molecular Docking and Molecular Dynamic Effects of Omeprazole on CDKs 2, 4, and 6 as a Potential CDK Inhibitor in Cancer Treatment
Authors: Jamali Navid , Mohseni Roohollah , Zareei Mansoor , Saffari-Chaleshtori Javad
Published: January 2024

Introduction:

Cyclin-dependent kinases (CDKs) are serine/threonine kinase proteins that
regulate the cell cycle through phosphorylation and dephosphorylation. These proteins are a main
target in cancer therapy. This study investigated the effect of omeprazole on CDK2, CDK4, and
CDK6 through simulation studies.

Methods:

To investigate the interaction between omeprazole and CDK2, 4, and 6, the threedimensional
structure of omeprazole was obtained from PubChem, and the structures of CDK2, 4,
and 6 were acquired from RCSB servers. The proteins were then simulated for 50 nanoseconds using
the GROMACS 2021 platform before the docking process. Next, Autodock v.4.2.6 software was used
to bind omeprazole as a ligand to these proteins, and a molecular dynamics simulation of the resulting
protein-ligand complex was conducted using GROMACS after the docking process.

Results:

Omeprazole exhibited a high affinity for interacting with CDK2, 4, and 6, mainly occurring
in the ATP binding site of CDK4. However, the docking of omeprazole in the CDKs induced conformational
changes in their structures, which could potentially affect their function and lead to cell
cycle arrest.

Conclusion:

Omeprazole, which is a proton pump inhibitor, can induce cell cycle arrest by interacting
with the ATP-binding site of CDK4. Moreover, it can also induce conformational changes in
CDK2, CDK4, and CDK6 through high-affinity interactions with specific amino acid residues.
Prevalence of Bruxism in Children and Adolescents with Cerebral Palsy: Systematic Review and Meta-analysis
Authors: Kanhouche Nathalia , Pizzi Gabriela Godoy , Bim Nathalia Araujo , de Souza Rafael Celestino , Calvo Ana Flávia Bissoto , Floriano Isabela , Gimenez Thais , Imparato José Carlos Pettorossi , Tedesco Tamara Kerber
Published: January 2024

Aims:

To perform a systematic review and meta-analysis compiling data on the prevalence
of bruxism in children and adolescents with cerebral palsy.

Methods and Results:

Searches were carried out in PubMed/Medline, Web of Science, and Scopus
databases to identify the articles published by February 2023. Two independent reviewers,
and in duplicate, employed a two-stage process to select publications. The same two reviewers performed
the data extraction. Studies were included when the following eligibility criteria were met:
performed in children and/or adolescents with cerebral palsy and reporting bruxism. Potentially eligible
studies were read in full and excluded that: not presented numerical data on the prevalence
of bruxism; not reported how the bruxism was assessed; not reported data about the cerebral palsy;
and not an observational study. The risk assessment of bias was assessed by the Newcastle-
Ottawa Scale. After reading the titles and abstracts of the 358 identified articles, eight articles
from 1966 to 2020 were included. The main reason for not including the studies was not to report
data about bruxism (59.3%), and 44.5% were excluded for not reporting data from patients
with cerebral palsy. The studies were carried out in schools, university hospitals, or centers for patients
with special needs (Brazil, the United States, and Egypt). The pooled prevalence of bruxism
in children and adolescents with cerebral palsy was 46% (95%CI: 0.38-0.55) after removing one
study.

Conclusion:

The pooled prevalence of bruxism in children with cerebral palsy can be considered
high since almost half of the studied population is affected by this condition. PROSPERO
#CRD42021225781.
Missed Opportunities in Type 2 Diabetes Mellitus: A Narrative Review
Authors: Kwok Chun Shing , Phillips Anne , Mukherjee Supriyo , Patel Mahendra G. , Hanif Wasim
Published: January 2024

Background:

Type 2 diabetes mellitus (T2DM) is a significant health problem around
the world.

Objective:

This review aims to define missed opportunities and how they apply to patients with
T2DM.

Method:

This narrative review describes the natural history of T2DM and also describes where
missed opportunities may arise.

Results:

Missed opportunities may relate to prevention, early detection, diagnosis, and treatment
of diabetes. The cornerstone of T2DM prevention is the control of modifiable risk factors and
lifestyle changes to potentially prevent diabetes. Early detection of T2DM is important as it is a
chronic condition that can progress rapidly if untreated. Missed opportunities related to the diagnosis
of T2DM draw attention to the heterogeneous presentation of diabetes. The condition can be
incidentally identified in asymptomatic patients, so all healthcare professionals should be aware of
the disease. Furthermore, it is not unexpected that patients with atypical symptoms may have a
delay in diagnosis. The treatment-related missed opportunities in T2DM are broad and include
self-care, education, remission of T2DM, risk factor management, prevention of complications,
medication therapy and compliance, as well as individualized care. Considering patient pathways
is a useful approach to evaluate missed opportunities in patient care.

Conclusion:

Missed opportunities are a concept that is not often considered in diabetes care, which
calls upon reflection of real-world activities and consideration of whether patient outcomes could
have been improved with changes in decision-making. Future studies that aim to improve patient
care should consider this concept.
Overview of Dietary Supplements Use: A Narrative Review
Authors: Hasan Mariam , Allehdan Sabika , Alalwan Tariq , Perna Simone , Tayyem Reema
Published: January 2024

Dietary supplements are ingestible nutrient products used in individuals’ diets to meet
their adequate intake of nutrients required for general health purposes. This review aims to explore
the impact of using dietary supplements in relation to communicable and non-communicable
diseases, as well as some adverse effects caused by dietary supplements. Findings indicated that vitamin
D supplements can aid in recovery from flu and COVID-19. Folic acid can reduce stroke incidents
among adults with hypertension. Moreover, vitamin C or calcium intake is significantly associated
with lowering diabetes risk. Advantageous effects have been reported of high doses of vitamin
C against breast cancer. Moreover, frequent consumption of vitamin E reduced the risk of
chronic lung diseases by 10%. In conclusion, the present review confirms the beneficial health effects
of dietary supplement consumption and suggests further investigations for a better understanding
of their mechanisms in the prevention and treatment of communicable and non-communicable
diseases.