bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantitative EEG Based on Direct Recording and Source Localization Estimation in Repetitive Hand Motor Activity
Authors:   Doctoral Program Engineering Physics, Faculty of Industrial Technology, Institute of Technology Bandung, Ganesha 10, Bandung, Indonesia, Masitoh  , Suprijanto  ,   Laboratory of Medical Instrumentation, Instrumentation and Control Research Group, Faculty of Industrial Technology, Institute of Technology Bandung, Ganesha 10, Bandung, Indonesia, Putri Finda D. ,   Laboratory of Medical Instrumentation, Instrumentation and Control Research Group, Faculty of Industrial Technology, Institute of Technology Bandung, Ganesha 10, Bandung, Indonesia, Nadhira Vebi ,   Laboratory of Medical Instrumentation, Instrumentation and Control Research Group, Faculty of Industrial Technology, Institute of Technology Bandung, Ganesha 10, Bandung, Indonesia
Published: March 2023

Electroencephalography (EEG) has been widely used in clinical practice as a tool to guide an efficient post-stroke functional recovery program and adjust the rehabilitation training program. EEG has some advantages in temporal resolution, portability, and relatively low cost. Motor-related brain activities can be quantified by measuring the mu rhythm’s event-related desynchronization (ERD), acquired from a direct surface EEG recording. The common problem of direct surface EEG is the crosstalk between brain regions that are unrelated to the sensorimotor cortex. This problem can be solved through the EEG source localization technique. Essentially, the idea of source reconstruction is to estimate the primary cortical current densities during the given EEG recording across the head surface. The recent work aims to compare EEG power spectral density (PSD) analysis and source localization. Modification of exact-Low Resolution Brain Electromagnetic Tomography (eLORETA) was used as an EEG source localization method. EEG data recording was performed on a healthy, able-bodied male subject using 21 electrodes based on the case study’s 10-20 electrode placement system. The subject was asked to perform basic hand movements, i.e., grasping with and without hand load. Mu power was calculated from the electrodes that are located around the motor cortex (C3 and C4), while the average current density was calculated from the Brodmann Area (BA) 4 and 6, both during grasping and relaxation (baseline). The comparison showed that during grasping, there was a decrease in aver-age current density around BA-4 and BA-6 and a decrease in mu power at C3 and C4 when compared to baseline. These results indicate: (1) the activity of mu rhythm’s ERD around the sensorimotor cortex during hand movement; and (2) the possibility of using the EEG source localization method as an alternative biofeedback modality.
Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits
Authors: Park Joshua K , Bafna Shantanu , Forrest Iain S , Duffy Áine , Marquez-Luna Carla , Petrazzini Ben O , Vy Ha My , Jordan Daniel M , Verbanck Marie , Narula Jagat , Rosenson Robert S , Rocheleau Ghislain , Do Ron
Published: March 2023

Background:

Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH, and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems.

Methods:

Here, we conducted a phenome-wide, two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) regression to systematically infer the causal effects of plasma TG levels on 2600 disease traits in the European ancestry population of UK Biobank. For replication, we externally tested 221 nominally significant associations (p<0.05) in an independent cohort from FinnGen. To account for potential horizontal pleiotropy and the influence of invalid instrumental variables, we performed sensitivity analyses using MR-Egger regression, weighted median estimator, and MR-PRESSO. Finally, we used multivariable MR (MVMR) controlling for correlated lipid fractions to distinguish the independent effect of plasma TG levels.

Results:

Our results identified seven disease traits reaching Bonferroni-corrected significance in both the discovery (p<1.92 × 10-5) and replication analyses (p<2.26 × 10-4), suggesting a causal relationship between plasma TG levels and ASCVDs, including coronary artery disease (OR 1.33, 95% CI 1.24–1.43, p=2.47 × 10-13). We also identified 12 disease traits that were Bonferroni-significant in the discovery or replication analysis and at least nominally significant in the other analysis (p<0.05), identifying plasma TG levels as a novel potential risk factor for nine non-ASCVD diseases, including uterine leiomyoma (OR 1.19, 95% CI 1.10–1.29, p=1.17 × 10-5).

Conclusions:

Taking a phenome-wide, two-sample MR approach, we identified causal associations between plasma TG levels and 19 disease traits across organ systems. Our findings suggest unrealized drug repurposing opportunities or adverse effects related to approved and emerging TG-lowering agents, as well as mechanistic insights for future studies.

Funding:

RD is supported by the National Institute of General Medical Sciences of the National Institutes of Health (NIH) (R35-GM124836) and the National Heart, Lung, and Blood Institute of the NIH (R01-HL139865 and R01-HL155915).
Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
Authors: Sidhaye Jaydeep , Trepte Philipp , Sepke Natalie , Novatchkova Maria , Schutzbier Michael , Dürnberger Gerhard , Mechtler Karl , Knoblich Jürgen A
Published: March 2023

During development of the human cerebral cortex, multipotent neural progenitors generate excitatory neurons and glial cells. Investigations of the transcriptome and epigenome have revealed important gene regulatory networks underlying this crucial developmental event. However, the posttranscriptional control of gene expression and protein abundance during human corticogenesis remains poorly understood. We addressed this issue by using human telencephalic brain organoids grown using a dual reporter cell line to isolate neural progenitors and neurons and performed cell class and developmental stage-specific transcriptome and proteome analysis. Integrating the two datasets revealed modules of gene expression during human corticogenesis. Investigation of one such module uncovered mTOR-mediated regulation of translation of the 5’TOP element-enriched translation machinery in early progenitor cells. We show that in early progenitors partial inhibition of the translation of ribosomal genes prevents precocious translation of differentiation markers. Overall, our multiomics approach proposes novel posttranscriptional regulatory mechanisms crucial for the fidelity of cortical development.
‘Are we laughing at the same?’
Authors: Žákovská Iveta , Carmen Maíz-Arévalo  , Ying Cao
Published: March 2023

Humour is often employed as a coping mechanism, with therapeutic effects on those producing and receiving it (Christopher 2015; Samson & Gross 2012). This buffering effect of humour might explain why, at the time of an international pandemic like Covid-19, human beings, independently of their cultural origin, have resorted to humour as a means of alleviating uncertainty and fear, and of enhancing feelings of connection and bonding with others. The proliferation of Covid-related humour has also led to a wide range of studies, with special attention to memes. However, contrastive studies are more limited, especially those comparing very different languages and cultural realities such as the Chinese, the Czech and the Spanish ones. This paper aims to redress this imbalance by analysing a corpus of 300 Covid-memes (100 memes per language). More specifically, we intend to answer the following questions: (i) what dimension(s) of humour are predominant in each language? (ii) what actors do the memes in the three countries target? and (iii) to what extent can these preferences relate to cultural differences/similarities? Applying a mixed-method approach, results show that there seems to be a global preference for affiliative humour while aggressive (and self-deprecating) humour appears to be more culturally bound, with a higher frequency in the Czech and Spanish datasets in contrast to the Chinese one. Likewise, the Czech and Spanish dataset share a significantly higher number of common frames, which might be pointing to a more European, Western type of humour in comparison to the Chinese approach (Jiang et al. 2019).
Gram-negative ESKAPE bacteria bloodstream infections in patients during the COVID-19 pandemic
Authors: Alcántar-Curiel María Dolores , Huerta-Cedeño Manuel , Jarillo-Quijada Ma Dolores , Gayosso-Vázquez Catalina , Fernández-Vázquez José Luis , Hernández-Medel María Luisa , Zavala-Pineda Manuelita , Morales-Gil Miguel Ángel , Hernández-Guzmán Verónica Alejandra , Bolaños-Hernández Manuel Ismael , Giono-Cerezo Silvia , Santos-Preciado José Ignacio
Published: March 2023

Bloodstream infections due to bacteria are a highly consequential nosocomial occurrences and the organisms responsible for them are usually multidrug-resistant. The aims of this study were to describe the incidence of bacteremia caused by Gram-negative ESKAPE bacilli during the COVID-19 pandemic and characterize the clinical and microbiological findings including antimicrobial resistance. A total of 115 Gram-negative ESKAPE isolates were collected from patients with nosocomial bacteremia (18% of the total bacteremias) in a tertiary care center in Mexico City from February 2020 to January 2021. These isolates were more frequently derived from the Respiratory Diseases Ward (27), followed by the Neurosurgery (12), Intensive Care Unit (11), Internal Medicine (11), and Infectious Diseases Unit (7). The most frequently isolated bacteria were Acinetobacter baumannii (34%), followed by Klebsiella pneumoniae (28%), Pseudomonas aeruginosa (23%) and Enterobacter spp (16%). A. baumannii showed the highest levels of multidrug-resistance (100%), followed by K. pneumoniae (87%), Enterobacter spp (34%) and P. aeruginosa (20%). The blaCTX-M-15 and blaTEM-1 genes were identified in all beta-lactam-resistant K. pneumoniae (27), while blaTEM-1 was found in 84.6% (33/39) of A. baumannii isolates. The carbapenemase gene blaOXA-398 was predominant among carbapenem-resistant A. baumannii (74%, 29/39) and blaOXA-24was detected in four isolates. One P. aeruginosa isolate was blaVIM-2 gene carrier, while two K. pneumoniae and one Enterobacter spp were blaNDM gene carriers. Among colistin-resistant isolates mcr-1 gene was not detected. Clonal diversity was observed in K. pneumoniae, P. aeruginosa and Enterobacter spp. Two outbreaks caused by A. baumannii ST208 and ST369 were detected, both belonging to the clonal complex CC92 and IC2. A. baumannii was associated with a death rate of 72% (28/32), most of them (86%, 24/28) extensively drug-resistant or pandrug-resistant isolates, mainly in patients with COVID-19 (86%, 24/28) in the Respiratory Diseases Ward. A. baumannii isolates had a higher mortality rate (72%), which was higher in patients with COVID-19. There was no statistically significant association between the multidrug-resistant profile in Gram-negative ESKAPE bacilli and COVID-19 disease. The results point to the important role of multidrug-resistant Gram-negative ESKAPE bacteria causing bacteremia in nosocomial settings before and during the COVID-19 epidemic. Additionally, we were unable to identify a local impact of the COVID-19 pandemic on antimicrobial resistance rates, at least in the short term.
Evaluation of a dill (Anethum graveolensL.) gene bank germplasm collection using multivariate analysis of morphological traits, molecular genotyping and chemical composition to identify novel genotypes for plant breeding
Authors: Kadoglidou Kalliopi , Cook Catherine , Boutsika Anastasia , Sarrou Eirini , Mellidou Ifigeneia , Aidonidou Christina , Grigoriadis Ioannis , Angeli Andrea , Martens Stefan , Georgiadou Vasiliki , Moysiadis Theodoros , Ralli Parthenopi , Mylonas Ioannis , Tourvas Nikolaos , Michailidis Michail , Kalivas Apostolos , Maloupa Eleni , Ganopoulos Ioannis , Xanthopoulou Aliki
Published: March 2023

Dill (Anethum graveolensL.) is an aromatic herb widely used in the food industry, with several commercial cultivars available with different qualitative characteristics. Commercial cultivars are usually preferred over landraces due to their higher yield and also the lack of improved landraces than can be commercialized. In Greece, however, traditional dill landraces are cultivated by local communities. Many are conserved in the Greek Gene Bank and the aim here was to investigate and compare the morphological, genetic, and chemical biodiversity of twenty-two Greek landraces and nine modern/commercial cultivars. Multivariate analysis of the morphological descriptors, molecular markers, and essential oil and polyphenol composition revealed that the Greek landraces were clearly distinguished compared with modern cultivars at the level of phenological, molecular and chemical traits. Landraces were typically taller, with larger umbels, denser foliage, and larger leaves. Plant height, density of foliage, density of feathering as well as aroma characteristics were desirable traits observed for some landraces, such as T538/06 and GRC-1348/04, which were similar or superior to those of some commercial cultivars. Polymorphic loci for inter-simple sequence repeat (ISSR) and start codon targeted (SCoT) molecular markers were 76.47% and 72.41% for landraces, and 68.24% and 43.10% for the modern cultivars, respectively. Genetic divergence was shown, but not complete isolation, indicating that some gene flow may have occurred between landraces and cultivars. The major constituent in all dill leaf essential oils wasα-phellandrene (54.42–70.25%). Landraces had a higherα-phellandrene and dill ether content than cultivars. Two dill landraces were rich in chlorogenic acid, the main polyphenolic compound determined. The study highlighted for the first-time Greek landraces with desirable characteristics regarding quality, yield, and harvest time suitable for breeding programs to develop new dill cultivars with superior features.
Atypical ‘long-tailed’ cockroaches arose during Cretaceous in response to angiosperm terrestrial revolution
Authors: Li Xin-Ran , Huang Di-Ying
Published: March 2023

Typical cockroaches are flat, broad, with large pronotum and wings covering the body. This conserved morphotype dates back to the Carboniferous, during which the ancestral cockroaches, or roachoids, originated. On the other hand, the ovipositor of cockroaches gradually reduced during the Mesozoic, coupled with a major shift of reproductive strategy. By the Cretaceous, long external ovipositors became rare, most cockroaches used very short or even hidden internal ovipositors to fabricate egg cases (oothecae), which is an innovation for egg protection. Here, we describe two cockroaches from mid-Cretaceous Myanmar amber:Ensiferoblatta oecanthoidesgen. et sp. nov. (Ensiferoblattidae fam. nov.) andProceroblatta colosseagen. et sp. nov. They are slim, elongate, fusiform, with longitudinal pronotum, and have long external ovipositors. The combination of these traits represents a unique morphotype, which resembles crickets and katydids (Ensifera) more than general cockroaches.EnsiferoblattaandProceroblattamay be arboreal, feeding on and/or laying eggs into certain angiosperms that newly emerged. Their open habit causes latent impairment to viability, and may contribute to their extinction. These new taxa are the youngest members of the ancient, extinct group of cockroaches, namely Eoblattodea, which are characterized by long ovipositors. We speculate that the extinction of certain gymnosperm hosts almost ended the 200-My triumph of Eoblattodea. Despite an attempt to adapt to angiosperm hosts,Ensiferoblatta,Proceroblattaand suchlike cockroaches as an evolutionary dead end failed to save Eoblattodea from extinction. The lack of protection for eggs (maternal care in particular) might accelerate the extinction of Eoblattodea as a whole.
Impact of Family Participatory Care on Neonates- A Non Randomised Interventional Study
Authors: Amit . , Kumar Rakesh , Agarwal Karnika , Singh Brajendra , Kumar Surendra , Garg Nupur
Published: March 2023

Introduction: Family Participatory Care (FPC) is a unique concept which involves parents in caregiving to their admitted babies. It helps in defining the family's role in clinical care delivery to newborns along with doctors and nurses. The Neonatal Intensive Care Unit (NICU) is the ideal area for FPC to take place because of the unique and vulnerable nature of the mother-neonate relationship as neonates that are admitted, face immense trials from their first day of life. Aim: To know the effect of FPC on outcome of admitted neonates, analyse the impact of this model on breastfeeding rate and to compare the rate of Kangaroo Mother Care (KMC) being given to neonates at follow-up. Materials and Methods: It was a non randomised interventional study done from August 2020 to April 2021, in the NICU at Maharaja Agrasen Medical College, Agroha, Hisar, Haryana, India. Two hundred neonates, who were sequentially admitted and later discharged, were taken into account, out of which, first 100 were taken as controls and next 100 were taken in the intervention group. Routine treatment and care were given to all the admitted neonates. In addition to this, parents of the study group of newborns were given education through four audio-visual sessions, comprising hygiene measures for entry into nursery, correct method of breastfeeding, KMC and then care at home after discharge. Follow-up was done after one week of discharge and at six weeks of age. Outcome measures were breastfeeding rate and KMC rate which were compared between two groups, at discharge and at follow-up of six weeks of age. Results: The mean birth weight of neonates, mean gestational age and the socioeconomic status were comparable in both the groups. Mean duration of hospital stay was 7.13 (±4.95) days in study group and 8.06 (±5.40) days in control group (p=0.206). Mean weight at discharge and that at six weeks was comparable in both groups. However, the average weight gain per day was significantly higher (25.61 g) in the study group than the control group (18.92 g). At discharge, 92 babies in the control group and 87 in the study group were given exclusive breastfeeding or expressed breast milk with spoon feeding. At six weeks follow-up, this number was 91 in the study group and 70 in the control group (p=0.001). KMC was given to all the neonates at discharge who had birth weight less than two kg. Among them, at the time of follow-up, 33/36 in the case group and 5/37 in the control group were receiving KMC (p-value 0.001). Conclusion: FPC is feasible and effective model in terms of better neonatal outcome.
Comparison of Parallelism of Different Levels of Ala-Tragus Lines to Occlusal Plane in Dentate Subjects via Cephalometric Analysis: A Cross-sectional Study
Authors: Jamwal Manasvi , Mittal Sanjeev , Sukhija Urvashi , Dhindsa Jeewan Bachan , Singh Jaskirat , Monica Manini
Published: March 2023

Introduction: In prosthodontics, fabrication of Complete Denture (CD) is a challenging task because numerous factors have to be taken care of while rehabilitating the patients. The establishment of Occlusal Plane (OP) should be adaptable with the functional activity of the stomatognathic system. Aim: To ascertain the parallelism of different levels of ala-tragus lines to the OP in class 1 occlusion among dentate subjects via cephalometric analysis. Materials and Methods: A cross-sectional study was conducted in the Department of Prosthodontics, Maharishi Markandeshwar College of Dental Sciences and Research, Mullana, Ambala, February 2020 to September 2021. A total of 100 subjects were included in the study which included 50 males and 50 females. The various cephalometric parameters traced were Sella (S), Gnathion (Gn), OP, Anterior Nasal Spine (ANS). Metallic balls were placed on the lower border of ala of nose and tragus which was divided into 3 parts: superior, middle and inferior. Lateral cephalograms were shot for all subjects. The data collected was tabulated for easy interpretation and subjected to statistical analysis using Analysis of Variance (ANOVA), post-hoc test. Results: The mean angular measurement of angle I was highest followed by angle OP, angle M and least in angle S in both males and females. The comparison of the mean angle S was found to be significant (p<0.001) when subjected to one way ANOVA test, there was non-significant difference observed between angle OP and Angle I in males (p-value 0.464), and Angle OP and Angle M in females (p-value 0.984). Conclusion: Clinically, from the present cephalometric study it can be suggested that in males, the inferior point on the tragus and in females, the middle point on the tragus can be used to mark the camper’s plane.
Use of Cyclosporine for the Treatment of Stevens- Johnson syndrome and Toxic Epidermal Necrolysis Induced by Carbamazepine- A Case Report
Authors: Malu Sanket G , Beedimani Ravindra S , Jeevanagi Santoshkumar R
Published: March 2023

Stevens Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare, potentially life threatening, severe mucocutaneous adverse reactions characterised by extensive epidermal detachment, erosion of mucosa and severe constitutional symptoms. However, the use of Carbamazapine may be associated with a plethora of adverse effects, the most serious being SJS/TEN, wherein the patient typically presents with fever, skin eruption and mucosal involvement. It occurs between 1/1,000 and 1/10,000 new exposures to the drug. Here, the authors report a case of severe life threatening SJS/TEN induced by Carbamazepine in a three-year-old boy who presented with high grade fever, skin rash and all mucosal involvement. This condition is best approached with immediate discontinuation of offending drug and prompt administration of oral cyclosporine. The case is being reported to emphasise the need for timely diagnosis and prompt treatment with Cyclosporin for successful outcome as it can cause irreversible organ damage or death if untreated early
Histopathological Changes of Placenta in Maternal Hypertensive Disorders and its Association with Birth Weight: A Case-control Study
Authors: Sharma Nimisha , Kahlon Namrata , Singh Mitasha , Jindal Ananya , Pujani Mukta , Das Asim
Published: March 2023

Introduction: One of the most common complications during pregnancy is hypertension. It leads to pathological changes which reduce the placental blood flow. Hypertensive disorders are strongly associated with foetal growth restriction, prematurity, lower foetal birth weights and contribute largely to perinatal mortality and morbidity. Aim: To study the histomorphological changes of placenta in cases of maternal hypertensive disorders and compare it with normal controls as well as find out its association with neonatal birth weight. Materials and Methods: A case-control study was conducted at the Department of Pathology of a Tertiary Care Hospital, Faridabad, Haryana, India. Duration of the study was 2 months from July to August 2018. This study is a part of Indian Council of Medical Research (ICMR) Short Term Studentship (STS) scheme for MBBS students. Control group was formed by 30 placenta of full term deliveries without any complications and 30 placenta of the females presenting with hypertensive pregnancies formed the case group. Specimens of placenta were studied in detail for morphological and histological changes. Neonatal Birth weight was recorded just after delivery of all the cases and controls. Analysis of statistical difference between the means of both groups was performed using student unpaired t-test. The data obtained was entered in Microsoft excel sheet and statistically analysed using Epi Info version 7. Results: Mean maternal age for cases was 28.60 years and controls were 25.23 years. This association was found to be significant. Mean for gestational weeks at the time of delivery was 34.93 weeks in cases and 37.20 weeks in controls (p-value <0.0001). Average placental weight in cases was 410.20 grams and in controls was 480.80 grams (p-value <0.001). Histopathological changes comprised of Syncytial knot formation, Cytotrophoblasts proliferation, proliferation of endothelial lining of capillaries, stromal fibrosis, calcification, hyalinisation of villi and infarction were comparatively more frequent in cases (n=30). Mean neonatal birth weight was found to be 2809.67±128.32 grams in control group as compared 2427.67±152.22 grams in cases (p-value <0.001). Conclusion: During pregnancy significant histomorphological changes in placenta are caused due to hypertensive disorders which lead to harmful and severe foetal outcomes. A valuable insight into the mechanism of placental dysfunction can be achieved through a detailed examination after delivery.
Disclosure of Sustainable Indicators in Grids of Companies of The Industrial Goods Sector - Transportation
Authors: Lugoboni Leonardo Fabris , Zittei Marcus Vinicius Moreira , Santos Marcia Maria dos , Fiorini Filipe Antônio , Nascimento José Orcelio do
Published: March 2023

O objetivo do presente estudo é observar quais indicadores de sustentabilidade estão sendo evidenciados na Global Reporting Initiative das empresas de transporte. A pesquisa foi realizada em 7 (sete) empresas do setor econômico de bens industriais e mineração do setor de transporte. No setor econômico de bens industriais e mineração, foram pesquisados os segmentos de exploração de rodovias, ferrovias e rodovias, listados como Novo Mercado e Nível 1. Trata-se de uma pesquisa baseada em documentos publicados pelas empresas avaliadas, onde houve avanços na divulgação dos Indicadores da Global Reporting Initiative, formados por princípios e indicadores econômicos, sociais e ambientais, tendo como importância a clareza, a qualidade e a credibilidade das informações. divulgado, sendo certificado em todo o mundo. Verificou-se que a empresa VALE S / A apresentou 93% de seus índices entre as empresas que obtiveram o melhor resultado, logo após JSL com 90%, COSAN LOG com 84%, CCR S / A AUTOBAN com 71% ECOPISTAS - GRUPO ECOVIAS apresentou 66%, a INVEPAR 44% e a empresa ALL AMER LAT apresentou um índice baixo, com 39% da divulgação de seus relatórios. No entanto, mesmo com o esforço da GRI em desenvolver um modelo de relatório de sustentabilidade mais sólido e abrangente, seu objetivo nos setores pesquisados ainda precisa ser aprimorado para que os vários usuários possam acessar o que realmente expressam a responsabilidade ambiental das organizações. e a empresa ALL AMER LAT apresentou um índice baixo, com 39% de divulgação de seus relatórios. No entanto, mesmo com o esforço da GRI em desenvolver um modelo de relatório de sustentabilidade mais sólido e abrangente, seu objetivo nos setores pesquisados ainda precisa ser aprimorado para que os vários usuários possam acessar o que realmente expressam a responsabilidade ambiental das organizações. e a empresa ALL AMER LAT apresentou um índice baixo, com 39% de divulgação de seus relatórios. No entanto, mesmo com o esforço da GRI em desenvolver um modelo de relatório de sustentabilidade mais sólido e abrangente, seu objetivo nos setores pesquisados ainda precisa ser aprimorado para que os vários usuários possam acessar o que realmente expressam a responsabilidade ambiental das organizações.
Atributos locais determinantes na criação de empresas na perspectiva de potenciais empreendedores
Authors: Tisott Sirlei Tonello , Ribeiro Sílvio Paula , Araújo Tamires Sousa , Albuquerque Alexandre Farias
Published: March 2023

Este artigo tem por objetivo geral identificar os atributos determinantes à criação de empresas no município de Três Lagoas, Mato Grosso do Sul, a partir da perspectiva de acadêmicos dos cursos de graduação de ciências contábeis e administração de empresas, considerados por este estudo, potenciais empreendedores. De maneira específica, interessa-nos verificar quais são os atributos influenciadores da criação de empresas na territorialidade eleita, bem como verificar se estes atributos podem ser classificados e organizados de maneira funcional para servirem de base às atividades empreendedoras em Três Lagoas. O delineamento da pesquisa, pautou-se na seguinte questão: quais são os atributos determinantes à criação de empresas na perspectiva de potenciais empreendedores que estão em processo de formação em curso de graduação voltados ao desenvolvimento e aplicação de práticas empreendedoras? O método analítico Survey foi utilizado para construção de uma abordagem quantitativa da situação de pesquisa proposta. A obtenção do corpus erigiu-se da aplicação de um questionário junto aos potenciais empreendedores. A análise dos dados obtidos, valeu-se do software SPSS, versão 22, baseada em análise fatorial exploratória. A partir dos resultados, foi possível identificar 10 (dez) atributos influenciadores da criação de empresas, são eles: ações individuais, histórias de sucesso, compartilhamento de ideais, trabalhadores talentosos, universidades, serviços de apoio, capital de investimentos, política/governo, infraestrutura e abertura de mercado. Os quais foram classificados em quatro categorias: cultural, suporte, capital e mercado local, com 67,95% de variância explicada.
Por Onde Anda o Marketing de Relacionamento?
Authors: Hoeckesfeld Lenoir , Cittadin Jackson , Hoffmann Estela Maria , Alves Claudia Silva Ribeiro , Souza Maria José Barbosa de
Published: March 2023

O objetivo deste artigo teórico é propor uma discussão conceitual entre Marketing de Relacionamento (MR), Práticas Contemporâneas de Marketing (PCM) e Customer Relationship Management (CRM), por meio de um framework que apresente a “relação” entre esses três construtos e com isso sugerir uma agenda de pesquisa na área. A metodologia empregada foi a revisão narrativa. O método baseia-se na análise de literatura, interpretação e análise crítica do pesquisador. A pesquisa é pioneira ao englobar a discussão de três importantes conceitos: Marketing de Relacionamento, Práticas Contemporâneas de Marketing e CRM. Além disso, faz a proposição de uma agenda de pesquisas futuras. Os principais resultados incluem a criação de um framework teórico e proposição de agenda de pesquisa envolvendo Marketing de Relacionamento, Práticas Contemporâneas de Marketing e CRM. Este estudo contribui para a reflexão sobre conceitos de marketing de relacionamento envolvendo os novos modelos de relação, considerando as novas tecnologias e conexões estabelecidas a partir delas. As práticas de marketing aplicadas ao marketing de relacionamento e as ferramentas tecnológicas utilizadas para tal são desafios contemporâneos que merecem atenção por parte de profissionais e pesquisadores da área.
Improving Handling Systems of Tomato (Solanum lycopersicum) in Cameroon
Authors: Djoukeng Henri Grisseur , Tangka Julius Kewir , Ndaji Nathaniel Tetu , Wafo Chanel Kevin Tokom , Assoumou Whitney Rakelle Anguezomo , Peyoumeya Nestor Lindou
Published: March 2023

In Cameroon, tomato (Solanum lycopersicum) is among the most important fruits with a consumption of about 35%. A 5-months study was conducted in two tomato production basins, namely Tsinfou and Litieu. This study aims to reduce postharvest losses of tomato for contribute to increase income and standard of living of producers in the Menoua division. The postharvest technics adopted by producers, transporters and traders were identified through investigations and direct observations. The rate loss of tomato and its deterioration over a certain period of time were evaluated. Also, the type, nature and causes of these postharvest losses were determined. The results from this study show that, inappropriate post-harvest technics are practiced in all links of the supply chain. The average rate loss during harvest, transport, conservation is 7.50%, 6.50% and 35.50% respectively. They are caused by mechanical, biological and microbial actions, environmental and socio-economic factors. These losses reduce actor's incomes and the availability of tomatoes on the market, hence the inaccessibility for poor citizens.  Avoiding overloading and mixed transport of tomato crates with other products and using planks in lorry to overlap crates to minimize compression are two technics implemented by this study for reduce tomatoes postharvest losses. Establishment of affordable processing and conservation units, qualified workforce and maintaining a good state of roads should be adopted.
The Check-and-Balance Affect on the Relationship between Financing Constraints and Investment Efficiency －Taking the Chinese Software and IT Industry as a Sample
Authors: Hsiao Chih-Yi , Wang Zi-Yang
Published: March 2023

This study explores the relationship between the degree of financing constraints and investment efficiency based on the moderator of the checks-and-balances mechanism using the Ordinary Least Square method and Quantile regressions for software and IT service sample industries of the Chinese listed companies from 2017 to 2021. The study finds that for software and IT service industries, the higher the degree of financing constraints, the worse the investment efficiency. Overall, the higher the degree of financing constraints, the greater the separation of powers between the chairman and the managing director, and the greater the checks and balances that can be exercised, resulting in a significant increase in investment efficiency. This is especially true in the very high and very low levels of investment efficiency. However, at any level of investment efficiency, the degree of independent directorship does not have a significant counterbalancing effect between financing constraints and investment efficiency and is even reversed at the average level of overall efficiency. Based on the above findings, this study also proposes corresponding recommendations.
Study of the Substitution of Marine Animal Oils in Maggot Flour by Vegetable Oils for the Growth and Larval Survival of African Catfish, Heterobranchus longifilis Valencienne, 1840 in Aquarium
Authors: Kimou N. B. , Tia B. C. , Koné A. , Atsé C. B. , Ouattara I. N.
Published: March 2023

This study showed clearly the effect of adding palm oil to the diet of farmed fish to replace marine animal oils. For this purpose, four foods based on maggot flour at 35% protein with the incorporation of palm oil, at different levels at 0, 2, 5 and 10% were tested in the to assess their impact on the improved growth performance, food utilization, survival rate and biochemical composition of Heterobranchus longifilis larvae

Four experimental diets were formulated based on the maggot meal as the main protein source. These diets were formulated at 35 % protein levels with maggot meal and maize flour as the major ingredients containing different concentrations of palm oil levels at 0, 2, 5, and 10 %. This study was carried out in the reproduction laboratory, at Oceanological Research Center, Abidjan, Côte d’Ivoire, between the periods of September to November 2022.

The diets were offered to the larvae (average initial weight 0.004 ± 0.001 g) three times a day ad libitum for 49 days. At the end of rearing, the results showed that the different experimental foods distributed did not influence the quality of the rearing environment.

The best growth was obtained with the larvae subjected to diet containing 2% palm oil with a final average weight of 3.21 g and a conversion index of 1.63. Beyond this rate, larval growth decreases. Survival rates vary from 70 to 73 %. The conversion ratios are not significantly different and ranged between 1.63 and 2.3. On the biochemical larvae submitted to diet containing 10 % of palm oil had body lipid content (2 %) and high ash rich. As against a gain of protein is observed with larvae submitted to diets containing 2 % palm oil reflects an effect of protein.  

From the present results, diet containing 2 % crude palm oil is considered optimal for Heterobranchus longifilis larvae.
Utilization of Cyber Extension Technologies among Fish Farmers in Osun State Nigeria
Authors: Oyetoro J. O. , Akinatro O. S. , Akinboye O. A.
Published: March 2023

The study analyzed the utilization of cyber extension technologies among fish farmers in Osun state Nigeria. Structured interview schedule was used to elicit primary data from 160 fish farmers selected through simple random sampling. Findings revealed that the mean number of ponds owned by the respondents was 5ponds. The mean years spent in formal schooling and fish farming experience were 15.5years and 6.8years respectively. There was high utilization of smartphone (Mean = 2.1) and laptop (Mean = 1.2) for cyber extension information on fish production. There was positive and significant relationships between respondents’ age (r= 0.566; p ≤ 0.05); household size (r=0.598; p ≤ 0.05); number of years spent schooling (r= 0.532; p ≤0.05); number of ponds owned (r= 0.268; p ≤ 0.05), annual income (r= 0.525; p ≤ 0.05) and utilization level of cyber extension technologies among fish farmers. The study concludes that high utilization of cyber extension technologies of smartphone and labtop are highly beneficial to obtaining fish production information The study recommended that fish farming information packages on cyber extension should address the identified challenges of poor technical know-how, this will assist farmer to improve their knowledge and use better strategies for fish production.
Development of Invasive Plant Recognition System Based on Deep Learning
Authors: Yang Zhuolei , Fan Zheming , Niu Chenyu , Li Peixin , Zhong Hongjie
Published: March 2023

A major ecological issue that has seriously harmed both human society and the environment is the invasion of alien plants. To stop the invasion of alien plants, it is crucial to create an effective and precise monitoring and early warning system. In this situation, deep learning and computer vision have significant potential to enhance plant monitoring on a wide scale. This study suggests a deep learning-based approach for identifying invasive plants. The user interface is developed as a mobile application (APP). The identification result can be acquired in 1 to 2 seconds after downloading the plant image from the APP, uploading it to the server, and using the convolutional neural network (CNN). The system had an average accuracy of 90.39% on the test set thanks to data augmentation and enhanced networks. The deep learning-based invasive plant identification system created in this study has demonstrated through experiments that it may effectively support botanical research and ecological environment monitoring.
To Study High-sensitivity CRP Levels in Overweight and Obese Individuals
Authors: Kumar Patamsetti Anil , Jha Sumit Kant , Prasad Anand , Jindal Nitesh , Bhandari Sanchit
Published: March 2023

The present study examines whether overweight and obese are inter related with low-grade systemic inflammation as measured by serum hs-CRP concentration. The present observational, cross-sectional study is from the department of medicine, CSS Hospital, Subharti Medical College, Meerut, to evaluate the profile of patients who came for routine health check-ups from December 2020 to January 2022. The study comprised 150 patients divided into three groups normotensives, normoglycemic adults of the age group 20-70 years based on BMI as Normal BMI (18.5-22.9 kg/m2), overweight (23-24.9 kg/m2) and obese (BMI>25 kg/m2), according to Asian standards by WHO. The mean age among the study subjects was 49.38±12.62 years. Out of 150 subjects, 83 (55.33%) were males and 67 (44.67%) were females. Normal, overweight, and obesity were found among 34%, 29.33%, and 36.67% of the subjects respectively. Normal and high hs-CRP was reported in 46% and 54% of the subjects respectively. The mean hs-CRP among the study subjects was 6.07±4.23. Mean FBS (mg/dL), WC (cm), TC (mg/dL), TGL (mg/dL), and HDL (mg/dL) among the study subjects was 102.94±13.03, 88.2±13.36, 161.84±52.56, 133.18±64.48 and 34.73±17.44 respectively. Mean hs-CRP was found to be highest in obese subjects (10.09±3.67) followed by overweight (6.74±2.48) and normal subjects (2.32±1.11). When hs-CRP was compared among normal vs overweight, normal vs obese, and overweight vs obese using a t-test, a significant difference was found. Pearson correlation analysis revealed a positive correlation between BMI, FBS (mg/dL), WC (cm), TC/HDL (mg/dL), TGL (mg/dL), and hs-CRP i.e. with an increase in these mentioned parameters, hs-CRP value also increases.

Conclusion: Obesity is a state of chronic inflammation that has a strong link to hs-CRP levels.
PENGAYAAN KOSA KATA BAHASA INGGRIS UNTUK PELAJAR USIA MUDA MENGGUNAKAN METODE TOTAL PHYSICAL RESPONSE (TPR)
Authors: Marina Marina , Rasyimah Rasyimah , Sari Dewi Kumala , Kurniawati Kurniawati
Published: March 2023

Program Pengabdian kepada Masyarakat ini dilaksanakan di Madrasah Ibtidaiyah Swasta (MIS) Meuraksa yang terletak di Desa Jambo Timu Kecamatan Blang Mangat Kota Lhokseumawe Aceh. Tujuan program ini yaitu untuk meningkatkan penguasaan kosa kata bahasa Inggris yang dimiliki oleh para pelajar dan menyediakan kesempatan untuk mempraktekkan kosa kata yang sudah mereka pelajari. Para pelajar ini belum memiliki kemampuan berbahasa Inggris yang memadai dikarenakan pihak sekolah belum memberikan pendidikan Bahasa Inggris secara formal. Hal ini mengakibatkan timbulnya permasalahan dimana penguasaan bahasa Inggris mereka belumlah mencapai tingkat yang cukup baik disebabkan penguasaan kosa kata yang masih rendah. Oleh karena itu sangatlah penting bagi mereka untuk mendapatkan pelatihan pengayaan kosa kata agar terjadi peningkatan penguasaan kosa kata. Sebagai solusi dari permasalahan yang dihadapi para pelajar ini, maka perlu diadakan pelatihan pengayaan kosa kata dengan menggunakan metode Total Physical Response (TPR). Metode TPR merupakan metode untuk pengajaran bahasa yang dalam penerapannya menggabungkan koordinasi perintah, ucapan dan gerak sehingga lebih mudah untuk menguasai suatu bahasa dalam pembelajarannya. Selain itu, kesempatan untuk mempraktekkan kosa kata yang sudah dipelajari juga diberikan dalam bentuk praktek pengucapan dan penulisan. Metode pelaksanaan dalam pelatihan ini meliputi (1) pengayaan kosa kata melalui metode TPR; (2) pelatihan pembalikan peran, dan (3) pelatihan urutan tindakan untuk mempraktekkan kosa kata yang sudah dipelajari. Dari kegiatan ini penguasaan kosa kata yang meningkat dapat membantu mereka dalam proses belajar di sekolah.
Studying Harms Is Key to Improving Psychedelic-Assisted Therapy—Participants Call for Changes to Research Landscape
Authors: McNamee Sarah , Devenot Neşe , Buisson Meaghan
Published: March 2023

This Viewpoint discusses serious adverse events linked to interactions between therapists and patients in trials of psychedelic-assisted therapy.
Association of Obesity With Diverticulitis in the Hispanic Community Health Study/Study of Latinos
Authors: Ma Wenjie , Hua Simin , Giovannucci Edward L. , Kaplan Robert C. , Strate Lisa L. , Chan Andrew T.
Published: March 2023

This cohort study evaluates the association between obesity and diverticulitis among Hispanic and Latino American individuals.
Predicting micronutrient deficiency with publicly available satellite data
Authors: Bondi‐Kelly Elizabeth , Chen Haipeng , Golden Christopher D. , Behari Nikhil , Tambe Milind
Published: March 2023

Micronutrient deficiency (MND), which is a form of malnutrition that can have serious health consequences, is difficult to diagnose in early stages without blood draws, which are expensive and time‐consuming to collect and process. It is even more difficult at a public health scale seeking to identify regions at higher risk of MND. To provide data more widely and frequently, we propose an accurate, scalable, low‐cost, and interpretable regional‐level MND prediction system. Specifically, our work is the first to use satellite data, such as forest cover, weather, and presence of water, to predict deficiency of micronutrients such as iron, Vitamin B12, and Vitamin A, directly from their biomarkers. We use real‐world, ground truth biomarker data collected from four different regions across Madagascar for training, and demonstrate that satellite data are viable for predicting regional‐level MND, surprisingly exceeding the performance of baseline predictions based only on survey responses. Our method could be broadly applied to other countries where satellite data are available, and potentially create high societal impact if these predictions are used by policy makers, public health officials, or healthcare providers.
Inkjet Printing Flexible Thermoelectric Devices Using Metal Chalcogenide Nanowires
Authors: Du Jingjie , Zhang Botao , Jiang Meng , Zhang Qihao , Zhang Keyi , Liu Yan , Wang Lianjun , Jiang Wan
Published: March 2023

Development of flexible thermoelectric devices offers exciting opportunities for wearable applications in consumer electronics, healthcare, human–machine interface, etc. Despite the increased interests and efforts in nanotechnology‐enabled flexible thermoelectrics, translating the superior properties of thermoelectric materials from nanoscale to macroscale and reducing the manufacturing costs at the device level remain a major challenge. Here, an economic and scalable inkjet printing method is reported to fabricate high‐performance flexible thermoelectric devices. A general templated‐directed chemical transformation process is employed to synthesize several types of 1D metal chalcogenide nanowires (e.g., Ag2Te, Cu7Te4, and Bi2Te2.7Se0.3). These nanowires are made into inks suitable for inkjet printing by dispersing them in ethanol without any additives. As a showcase for thermoelectric applications, fully inkjet‐printed Ag2Te‐based flexible films and devices are prepared. The printed films exhibit a power factor of 493.8 µW m−1 K−2 at 400 K and the printed devices demonstrate a maximum power density of 0.9 µW cm−2 K−2, both of which are significantly higher than those reported in state‐of‐the‐art inkjet‐printed thermoelectrics. The protocols of metal chalcogenide ink formulations, as well as printing are general and extendable to a wider range of material systems, suggesting the great potential of this printing platform for scalable manufacturing of next‐generation, high‐performance flexible thermoelectric devices.
Bio‐inspired Porous Composite Electrode for Enhanced Mass Transfer and Electrochemical Water Purification by Modifying Local Flow Pattern
Authors: Yu Yuan , Pei Shuzhao , Zhang Jinna , Ren Nanqi , You Shijie
Published: March 2023

Porous electrodes offer a new opportunity for flow‐through electrochemical water purification, but their irregular porous‐structure makes the local flow pattern and mass transfer performance inhomogeneous, unpredictable, and uncontrollable. In this study, a bio‐inspired design is reported for porous electrode by learning the micro‐scale architectures of the wings of butterfly and owl based on analogy between heterogeneous mass transfer and sound absorption. Results demonstrate that combining gyroid and perforated plate can produce strong periodic vortex and inertial flow in interpenetrating channels even at laminar flow region. This enables homogeneous, predictable and controllable flow patterns and enhanced mass transfer, which can be explained by uniformity analysis and physical field synergy. Based on experimental tests on Cu electrode fabricated by selective laser melting, the composite gyroid electrode generates the limiting current density of 83% higher than random porous‐structured electrode, accounting for nitrate removal as high as 95% by electrochemical denitrification. This study represents a paradigm shift to advance design for porous architectures by learning experiences of hydrodynamic behaviors from nature. In this way, it is feasible to enhance mass transfer by modifying local flow patterns on pore scale, which may have broader implications that extend to other heterogeneous reaction systems.