bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS KARTOGRAFI KASUS WABAH AFRICAN SWINE FEVER DI KABUPATEN DAIRI PROVINSI SUMATERA UTARA
Authors: Primatika Roza Azizah , Sumiarto Bambang , Widiasih Dyah Ayu , Drastini Yatri , Susetya Heru , Nugroho Widagdo Sri , Putri M.Th. Khrisdiana
Published: May 2023

African Swine Fever (ASF) is an infectious disease in pigs caused by the African Swine Fever virus (ASFV) with virus species in the Asfarviridae family and Asfivirus genus. African Swine Fever causes economic losses for pig farmers with the number of deaths until 100%. This study aims to determine the distribution of ASF disease directions in Dairi Regency, North Sumatra Province and clusters and outliers in ASF cases in 2019 and 2020. This research method uses cartographic analysis, namely the distribution of directions and clusters and outliers with Moran's Index. Software using ArcGIS 10.5. This study obtained the results that the distribution of ASF disease in Dairi Regency in 2019 had an average center in Siempat Nempu Hulu District with longitude coordinates of 98.265459 and latitude 2.8055450. The distribution of ASF cases in 2019 is in the northwest – southeast region with a rotation of 121.05°. The ASF case in 2020 has a mean center in Lae Parira District with coordinates of longitude 98.3998 and latitude 2.7367. Meanwhile, the distribution of ASF cases in 2020 is northwest – southeast with a rotation of 133.58°. The conclusion of this study can be seen that cases of swine mortality due to ASF virus have a pattern of distribution of ASF disease and ASF case groups in 2019 and 2020.
Pemberian Gliserol secara Oral dengan Dosis 2-4 Ml/Kg Berat Badan Meningkatkan Kadar Fisiologik Glukosa Darah: Kajian pada Kambing Kacang (Capra Aegagrus Hircus)
Authors: Melkianus Christin , Purnamaningsih Hary , Yanuartono Yanuartono , Widiyono Irkham
Published: May 2023

Tujuan dari penelitian ini adalah mengkaji pengaruh aplikasi gliserol secara oral drenching terhadap kadar glukosa darah pada kambing Kacang (Capra aegagrus hircus). Sebanyak 7 ekor kambing Kacang betina, umur ± 2 tahun, bobot badan 26 kg, kondisi tubuh BCS (2,5–3), tidak bunting, dan secara klinis sehat. Hewan dibagi menjadi 2 kelompok yakni kelompok perlakuan dengan larutan gliserol (G) dan kelompok perlakuan dengan air (A) sebagai kontrol. Larutan gliserol dibuat dengan melarutkan gliserol dalam air dengan perbandingan 1:1. Setelah melampaui masa adaptasi sekitar satu bulan, setiap hewan pada kelompok G diberi 2 kali perlakuan oral drenching larutan gliserol dengan dosis 4 ml/kg BB (G2) dan 8 ml/kg BB (G4), sedang setiap hewan kelompok A diberi air dengan dosis 4 ml/kg BB (A4) dan 8 ml/kg BB (A8). Pelaksanaan kedua perlakuan pada setiap hewan berselang 3 pekan. Sampel darah diambil sebelum (pada menit ke-0) dan pada menit ke-60, 120, dan 180 menit setelah oral drencing. Data yang diperoleh dianalisis dengan menggunakan ANOVA. P<0,05 ditentukan sebagai kriteria signifikansi. Hasil dari penelitian menunjukkan bahwa pemberian gliserol pada kelompok G2 dan G4 mengakibatkan peningkatan yang signifikan pada jam kedua dan belum menunjukkan penurunan sampai menit ke 180 yakni berada pada level 80.75 g/dL dan 88.30 mg/dL (P<0,05), sedang pemberian air dengan dosis yang sama pada kelompok A4 dan A8 tidak mengakibatkan perubahan kadar glukosa darah secara signifikan dan berada pada kisaran 58-66 mg/dL (P>0,05). Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwan pemberian gliserol secara oral drenching dengan dosis sampai 2-4 ml/kg BB pada kambing Kacang potensial meningkatkan kadar glukosa darah secara cepat dan bertahan tidak kurang dari 3 jam setelah pemberian.
Analisis Pemberian Serbuk Jahe Merah, Kunyit, dan Temulawak Dengan Metode Insilico dan Invivo pada Ayam Broiler
Authors: . Herawati , Al Jabbar Renanda Nur , Oktanella Yudit
Published: May 2023

This study aimed to eveluate effect of combination powder of red ginger (Zingiber officinale var. Rubrum), turmeric (Curcuma domestica), and temulawak (Curcuma xanthorrhiza) on the calculation of normal Liberkhun crypts by insilico and invivo methods. Molecular docking conducted in the pocket site of Interferon Lambda Receptor (IFN-λR) to modulate anti-inflammatory activity in chicken caecum. The study used 20 day old chickens (DOC) which were randomly grouped into 5 groups: negative control without treatment (P0) and powder addition group {0,5% (P1); 1%(P2); 1.5%(P3); 2%(P4)}. All chickens were reared for 35 days then chickens were euthanized using halal slaughter method and caecum organs were collected  for histopathological observations. all active substances red ginger (gingerol, shogaol); turmeric (curcumin,tetrahydrocurcumin); and temulawak (demethoxycurcumin, bisdemethoxycurcumin) can bind to IFN-λR. Curcumin (-6.0 kcal/mol) have highest affinity values. Invivo treatment showed significant effect (p<0.05) on normal calculation of Liberkhun crypts due to tissue damage. Tukey's test confirmed that negative group was significantly different from P2, P3, and P4 with an average (4.35 ± 1.09b; 5.6 ± 1.54c; and 5.7 ± 1.78c). This research suggests that the addition of combination powder by 1,5% can potentially used for anti-inflamatory agent that confirmed by insilico method.
Characterization of Newcastle Disease Virus Isolated from Peacocks in Palembang City, South Sumatra
Authors: Angeliya Liza , Mussama Akbar Agus Anshori , Alawiyah Syarifah , Guntoro Tri , Srihanto Eko Agus , Kristianingrum Yuli Purwandari , Asmara Widya , Wibowo Michael Haryadi
Published: May 2023

Introduction: Newcastle Disease (ND) is an infectious disease in various types of poultry caused by the Newcastle Disease Virus (NDV). Cases of ND in Indonesia have been reported in commercial and backyard chickens, pigeons, ducks and geese, even in eagles and peacocks. Peacock is a wild bird protected by Indonesia's Government Regulation No. 7 of 1999. This study aims to identify, isolate and characterize the NDV molecularly in cases diagnosed as ND in peacocks. Method: Samples were obtained from organs (lungs and spleen) of peacocks which showed neurological symptoms, diarrhoea and then died. Real-time RT-PCR ND was used to identify the cause of death of the peacock. Virus isolation and observation of embryonic changes and death were carried out on embryonic chicken eggs. Sequencing was carried out to characterize the F and HN entire genes of the NDV. The nucleotide sequences were analyzed using MEGA-X software, including amino acid prediction, analysis of genetic variation at the amino acid level, homology and construction of the phylogenic tree. Result: The results of the sample identification were positive for the Newcastle disease virus. Observations of chicken embryos are stunted, have few feathers, are haemorrhagic, and die in less than 60 hours. Virus isolation was obtained with a titer of 26. Molecular analysis showed that the RRQKRF cleavage site pattern in the F gene had homology of 95.8-97.6% and was in the same branching area as the previous ND virus in Indonesia. There were no amino acid mutations at the antigenic site, glycolysis and neutralization epitopes in the HN gene. Conclusion: The virus isolated from the peacock is a velogenic strain of NDV, subgenotype VII.2 and has a close genetic range to the NDV that has been previously reported in commercial and domestic poultry. This result shows that ND is also a threat to protected wild birds.
Effectiveness of Botanical Pesticides from Wastes of Virginia Tobacco Stems in Reducing Populations of Leaf-Sucking Pest and Occurrence of Virus Disease Symptoms on Potato Plants
Authors: Thei Ruth Stella Petrunella
Published: May 2023

The potato plant (Solanum tuberosum L.) is a tuber-producing plant which is rich in carbohydrates, protein and minerals, and can be used as a staple food, and potatoes have great potential as one of the horticultural crops that can support world food diversification. One of the constraining factors in increasing potato productivity is leaf-sucking pests including aphids (Aphids spp.,), whitefly (Bemisia tabaci), and thrips (Thrips Palmi Karny), which besides damaging plants directly, can act as vectors for viruses that cause potato plant diseases such as Potato virus Y (PVY) and Potato leaf roll virus (PLRV). These two viruses can cause quite severe damage and through the health of the seeds they produce, they can reduce potato productivity by up to 70-80%. This study aims to determine the effect of several concentrations of botanical pesticides from Virginia tobacco stem waste on the emergence of viral disease symptoms in potato plants. The experiment was carried out in Sembalun Bumbung Village, East Lombok Regency (Indonesia), which was arranged using a Randomized Block Design consisting of 6 treatments namely control, abamectin, and Virginia tobacco stem waste botanical pesticides with concentrations of 2, 4, 6 and 8 ml/L. The results showed that the botanical pesticides from Virginia tobacco stem waste were effective in reducing leaf-sucking pest populations and suppressing the intensity of leaf-sucking pest attacks and were able to suppress the emergence of viral disease symptoms, with a concentration of 8 ml/L botanical pesticides more effective than other treatments in controlling populations. and attacks by potato leaf-sucking pests suspected as virus vectors.
Review of research into teachers’ beliefs at home and abroad
Authors: Luo Lifei
Published: May 2023

Teachers’ belief is an important research field in teacher education research, and related practices and research have been increasing in recent years. This paper summarizes and sorts out the research on foreign language teachers’ beliefs in primary and secondary schools at home and abroad from four aspects: the definition of the concept of teachers’ beliefs, the influencing factors of teachers’ beliefs, the research on the relationship between teachers’ beliefs and teaching practices, and the research on teachers’ beliefs and teachers’ professional development. Specifically, teachers’ beliefs are the views, attitudes, and psychological tendencies that teachers hold for truth about teaching-related factors in the teaching process. Its formation and change are mainly affected by personal background factors and social environment factors; Teachers’ beliefs and teaching behaviors influence each other, but they are not always consistent; Teacher professional development is the driving force behind changes in teachers’ beliefs. Finally, the paper points out that the future research on teachers’ beliefs in China can also expand the research objects, pay attention to the application of qualitative research methods, and focus on the dynamic research of teachers’ beliefs and the research related to teachers’ beliefs and teachers’ professional development.
Research Paper on Desktop Assistant
Authors: Mandhalkar Lilesh , Potbhare Ishika , Walande Pratiksha , Yerme Durgesh , Chauhan Mr. Chandrapal
Published: May 2023

Abstract: The main thing of Artificial intelligence (AI) is the consummation of natural dialogue between humans and machines. There are numerous IT companies have used the dialogue systems technology to establish various kinds of Virtual assistants grounded on their operations and areas for adding commerce between mortal and machine, similar as Microsoft’s Cortana, Apple’s Siri, Amazon Alexa, Google Assistant. Like Microsoft Cortana we've created our own virtual desktop assistant only for Government College Of Engineering Chandrapur (GCOEC) using python which is suitable to run on any windows operating systems. We use python as a programming language because it has a multitude of libraries which can be used to create Artificial Intelligence. Our version of desktop assistant is capable of recognizing voice and voice commands. Desktop Assistant are programs on digital device like PC that hear and respond to verbal commands. Example, a user can say, “Open GCOEC Website” and the assistant will answer with the sanctioned website of GCOEC. Desktop Assistants can change the way of life of the people in a different manner. Bias is starting to build up in the community as AI’s are getting smarter in their own way to interact with humans in an easy language. The Desktop Assistant is a program that can fete mortal voices and can respond via integrated voice system. This paper will define the working of Desktop assistant, their main problems and limitations. In this paper it's described that the system of creating a Desktop assistant without using pall services, which will allow the expansion of similar bias in the future
Desarrollo de la región de Ñuble: prospectiva según la permeabilidad de los suelos
Authors: Rivas Maldonado Juan , Loyola Gómez Christian
Published: May 2023

Debido al aumento en la ocupación hu­mana del territorio y las perspectivas de desarrollo del mismo, se requieren diversos análisis de las ca­racterísticas de los suelos en la región de Ñuble, por lo cual se analiza la permeabilidad por constituirse en una variable a considerar en el poblamiento hu­mano, además este tipo de estudios se reconoce como insumo para la nueva región. Para ello, se aplica a los suelos de la región la metodología pro­puesta por la FAO, que se encuentra validada por una serie de estudios que la han antecedido, enfo­cados a la granulometría, porosidad y textura de los mismos, logrando establecer zonas que permiten predecir el comportamiento hidráulico, las cuales son información para la instalación de actividades productivas y el asentamiento. Sin embargo, la en­vergadura del territorio considerado ha descartado características puntuales necesarias de incorporar en futuras mediciones.
Evaluation of the Clinical Efficacy of Prednisolone in the Treatment of Inflammatory Bowel Diseases with Different Dosage Methods
Authors: Alekseeva O. P. , Krishtopenko S. V. , Alekseeva A. A.
Published: May 2023

Aim: to investigate the clinical efficacy of two methods of oral dosing of prednisolone (in mg and mg/kg) for the induction of remission for patients with ulcerative colitis (UC) and Crohn's disease (CD) using the technology of constructing and evaluating the effectiveness function (dose-effect relationship).

Material and methods. In this study were included 86 patients aged from 18 to 65 years with moderate or severe active inflammatory bowel disease (61 — UC, 25 — CD). All patients were treated with prednisolone at an initial daily dose from 30 to 60 mg with a subsequent tapering of dose. The clinical response to treatment was evaluated at the time of complete withdrawal of prednisolone using the generally accepted criteria. Two efficiency functions were constructed, compared and analyzed: the first — at the initial dosage of prednisolone in mg and the second calculating the dose in mg/kg of patient weight. The patients' body weight ranged from 41 to 98 kg. The “dose-effect” relationship for prednisolone was constructed with statistical transformation of the baseline clinical data and a quantitative expression of the actual doses and alternative responses into a graph of the effectiveness function. The mean value at each point was estimated based on the regression kernel scoring method.

Results. Two graphs of the “dose-effect” of prednisolone in mg and mg/kg of patient weight were constructed. The optimal clinically effective dose (OCED) when calculated in mg/kg of weight was 0.70 ± 0.01 (0.68 + 0.72) mg/kg with the corresponding effect 79.25 ± 6.26 (66.62 91.88) %. When two graphs in mg and mg / kg of weight were superimposed, it is shown that when an initial dose of 40 mg is prescribed without taking into account the patient's weight, the effect of therapy will be 25 % lower. Prescribing a dose of 60 mg per day without weight will be optimal for patients with a body weight of 85-90 kg. With a lower body weight, the clinical effect will not decrease, but the likelihood of recognized side effects of prednisolone should be expected in proportion to the decrease in body weight.

Conclusion. The clinical efficacy of two methods of prednisolone dosing (mg and mg/kg) for patients with IBD during the first induction course was compared.

Using a new technology for constructing and evaluating the effectiveness function (dose-effect relationship) allowed us to prove a reliable relationship between the body weight of patients with the clinical effect of prednisolone in patients with UC and CD. Based on the analysis of the dose-effect relationship, the optimal clinically effective dose of prednisolone for patients with UC and CD during the first induction course was established, equal to 0.70 mg/kg, which can be recommended for use in clinical practice for calculating individual doses.
Diagnostic Possibilities of Determining the Level of Faecal Calprotectin in Clinical Practice
Authors: Sheptulin A. A. , Kardasheva S. S. , Kurbatova A. A.
Published: May 2023

Aim: to analyze the publications devoted to the modern possibilities of determining the level of faecal calprotectin (FCP) in the diagnosis of various diseases.

Key points. In patients with already established diagnosis of inflammatory bowel diseases (IBD), dynamic monitoring of the level of FCP allows to assess the course and prognosis of the disease, as well as the effectiveness of treatment. The determining of FCP helps in the primary diagnosis of IBD (ulcerative colitis, Crohn's disease, microscopic colitis), contributing to their differentiation from functional bowel disorders, as well as in assessing the course of diverticular intestinal disease and celiac disease. The possibility of using FCP as a marker of colorectal cancer (CRC) and adenomatous polyps of the colon is also discussed.

Conclusion. Determining the level of FCP plays an important role in the diagnosis and assessment of the course of a number of gastroenterological diseases (primarily IBD). The significance of FCP as a marker of CRC requires further research.
Modern Approaches to H. pylori Eradication Therapy in Adults (Literature Review and Resolution of Experts Council)
Authors: Ivashkin V. Т. , Ulyanin A. I. , Mayev I. V. , Kozlov R. S. , Livzan M. A. , Abdulkhakov S. R. , Alekseyeva O. P. , Alekseyenko S. A. , Bordin D. S. , Dekhnich N. N. , Korochyanskaya N. V. , Lapina T. L. , Poluektova E. A. , Simanenkov V. I. , Trukhmanov A. S. , Khlynov I. B. , Tsukanov V. V. , Sheptulin A. A.
Published: May 2023

Aim: to analyze current approaches to H. pylori eradication therapy in adults and present the materials of Experts Council held on December 9, 2022 in Moscow.

General statements. H. pylori infection is the main etiological factor of gastritis, peptic ulcer, and gastric cancer. Eradication of H. pylori is recognized as a necessary measure to reduce the incidence of these diseases. The approaches to selecting an eradication regimen should be optimized to take into account epidemiological trends and achieve better treatment outcomes. The updated Maastricht VI Consensus Report presents the means to overcome the difficulties in selecting an approach to the treatment of H. pylori infection. However, eradication therapy remains challenging due to adverse events (primarily antibiotic-associated diarrhea), poor treatment tolerance and patient compliance. Eradication therapy can be optimized by supplementing treatment regimens with strain-specific probiotics that reduce adverse events, improve patient compliance and eradication rates, such as Saccharomyces boulardii CNCM I-745 strain with established efficacy.

Conclusion. The inclusion of certain probiotics in eradication regimens improves treatment tolerance, reduces the risk of adverse events, improves patient compliance and eradication rates.
First Russian Gastroenterology Olympiad
Authors: Ivashkin V. T. , Baranskaya E. K. , Shulpekova Yu. O. , Kardasheva S. S. , Dzhakhaya N. L.
Published: May 2023

On October 21, 22, 23, 2022, within the framework of the 122nd International Session of the National School of Gastroenterology, Hepatology (NSGH) of the Russian Gastroenterological Association (RGA), the First Russian Gastroenterology Olympiad was held.
R&D goal seeking and risk taking in biotechnology R&D investments
Authors: Ng Desmond
Published: May 2023

Rapid advances in biotechnology have made R&D (research & development) investments an important strategic goal. Yet, despite the increasing growth in R&D investments, an understanding of the decision-making processes surrounding the attainment of a firm’s R&D goal remains underdeveloped. This study addresses this gap where a firm’s R&D goal seeking process is offered. Specifically, unlike prior studies that focus on the firm’s financial goals (i.e. return on assets (ROA)), this R&D goal seeking process draws on a concept of R&D performance aspiration deviations (PAD) where it introduces risk-taking behaviors that impact a firm’s R&D investments. This study argues that a market’s technological progress or market dynamism also influences this R&D goal seeking process. In using fixed effects (FE) linear regressions, hypotheses were developed to examine these arguments in the biotechnology industry.
An infant case of ruptured umbilical hernia with eviscerated omentum after acupuncture
Authors: Lee Sang-Hun , Jung Eunyoung
Published: May 2023

Serious acupuncture-related complications are rare in infants. We experienced a case of a 58-day-old infant with an umbilical hernia who received acupuncture from a non-professional guardian. Upon initial examination in the emergency department, the omentum protruded through the skin defect caused by acupuncture performed on top of the hernia. The infant underwent emergency surgery, and subsequently recovered uneventfully.
Pedagogy- learning-methods-evaluation-experience
Authors: Vastavikta Bhagat  , moomal shekhawat
Published: May 2023

We at SEA believe that the pandemic has a granularity of meta, non-linear narratives that become useful in making sense of the relational complexities of the pandemic and society. Thus, we set out to collect stories of fears, joys, agilities, fragilities, friendships, networks, collectives, home, work, infrastructures, entrepreneurship, privileges, marginalizations, migrations, desperation, gender, equity, etc. The glossary as a method became useful to reflect on this granularity of experiences and account for slippages during these times. These spatio-temporal stories, when read together or as individual instances produce a new sense of the emergent contemporary. This framework also allows us to speculate on the kind of world we will inhabit once the storm has passed.

We draw on multiple readings to bring out the nuances and patterns of social life produced in a pandemic. This we hope would allow us to collectively reflect on the restructured ideas of the self, the collective, society, space, and time.

With the pandemic, the tools of Pedagogy had to be restructured and questioned. Here the sense of the field, as well as the tools to make sense of it, were put into the foreground. Meanwhile, crumbling modern institutions themselves began questioning the current tools and methods of learning and evaluating.
Niccolo Paganini: Life, illnes and virtuosity
Authors: Carol Frias Perez
Published: May 2023

Niccolo Pagani was born in Genoa, October 27, 1782, and died May 27, 1840.
He was an Italian composer considered one of the archetypes of violin virtuosity and one of the greatest representatives of the instrumental movement of Romanticism. He contributed with his contributions to the development of the "modern violin technique".
The 24 caprices for violin are one of his best known works and have served as inspiration for numerous composers.
In addition to the violin, he composed music for mandolin, guitar, viola and bassoon. His duets for violin and guitar and his compositions for string quartet stand out.
In this work a brief synthesis is made of the valuable contribution of the Italian school of violin in the pre-Paganini period, integrated by outstanding composers and performers. It highlights the Italian influence in the development of the art of violin playing. Paganini's biography describes his great abilities that led him to be considered as the amazing, original, unique and unrepeatable violinist in the history of music. The exceptional qualities of this musician are attributed to a genetic factor, associated to his intrinsic ability and training. A description is made of the peculiar somatic characteristics that Paganini possessed based on medical descriptions and those of some contemporary musicians. It has been hypothesized by several authors that the musician suffered from a hereditary connective tissue disorder and two possibilities have been proposed: that of a Marfan syndrome or that of an Ehlers-Landos syndrome. A summary of the clinical and biochemical criteria characterizing these conditions is presented.
What seems to be well founded is that he suffered from a "joint hypermobility syndrome", the true nature of which is conjectural, even if the hypothesis of a subtype III, hypermobile Ehlers- Danlos syndrome, may be favored. This condition affected him throughout his life, but contributed to make him the unrepeatable violinist he is remembered as in the history of music.
UPDATED Piano four-hands, "once again"
Authors: Alessandra Di Gennaro
Published: May 2023

This work arises from the long and passionate research the author has been conducting through the years as member of a professional piano duo (the Dirac PIano Duo). It aims firstly to understand why the piano four-hands repertoire has been for long time stigmatized as an “inferior
genre” despite its unquestionable value, and it also seeks to shed light on the contemporary repertoire for this medium, which is at present almost unknown, unperformed and undiscussed although it embodies masterpieces of undoubted artistic quality.
To do so, this thesis will first focus on the technical challenges, the distinctive features, the possibilities of expression as well as the limitations that characterize the piano four-hand repertoire, explaining why they are of a completely unique order and why they make the medium itself so distinctive and so controversial at the same time.
It will then explore the medium also from a more historical point of view, setting it into the social- cultural-musical context of the various periods and deeply investigating the process that has brought it from being considered one of the most fascinating socio-cultural phenomena of the nineteenth century to its almost complete extinction at the beginning of the twentieth century, with the ultimate scope of analyzing what is left of it nowadays and which is its role in the current musical scenario.
The results of the investigation point out that once the historical and sociological factors that have allowed for the extreme popularity of the medium fell short, the latter could finally assume a completely new value and be a site of compositional and performance innovation that absolutely deserves to be discovered, performed and analyzed.
The output of this dissertation have also inspired the young Chinese composer Ching-Fang Teng to write “Entanglement”, a proper homage to the medium and to its endless compositional potential.
Protective Renalase Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes
Authors: Bode Kevin , MacDonald Tara , Stewart Taylor , Mendez Bryhan , Cai Erica P. , Morrow Noelle , Lee Yu-Chi , Yi Peng , Kissler Stephan
Published: May 2023

Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic β-cells that produce insulin. The latest advances in stem cell (SC) β-cell differentiation methods have made a cell replacement therapy for T1D feasible. However, recurring autoimmunity would rapidly destroy transplanted SC β-cells. A promising strategy to overcome immune rejection is to genetically engineer SC β-cells. We previously identified Renalase (Rnls) as a novel target for β-cell protection. Here we show that Rnls deletion endows β-cells with the capacity to modulate the metabolism and function of immune cells within the local graft microenvironment. We used flow cytometry and single-cell RNA sequencing to characterize β-cell graft-infiltrating immune cells in a mouse model for T1D. Loss of Rnls within transplanted β-cells affected both the composition and the transcriptional profile of infiltrating immune cells in favor of an anti-inflammatory profile with decreased antigen-presenting capacity. We propose that changes in β-cell metabolism mediate local immune regulation and that this feature could be exploited for therapeutic goals.

Article Highlights

Protective Renalase (Rnls) deficiency impacts β-cell metabolism. Rnls-deficient β-cell grafts do not exclude immune infiltration. Rnls deficiency in transplanted β-cells broadly modifies local immune function. Immune cell in Rnls mutant β-cell grafts adopt a noninflammatory phenotype.
Genetic variations in HMGCR and PCSK9 and kidney function: a Mendelian randomization study
Authors: Park Sehoon , Kim Seong Geun , Lee Soojin , Kim Yaerim , Cho Semin , Kim Kwangsoo , Kim Yong Chul , Han Seung Seok , Lee Hajeong , Lee Jung Pyo , Joo Kwon Wook , Lim Chun Soo , Kim Yon Su , Kim Dong Ki
Published: May 2023

Background: The genetically predicted lipid-lowering effect of HMGCR or PCSK9 variant can be used to assess drug proxy effects on kidney function.Methods: Mendelian randomization (MR) analysis-identified HMGCR and PCSK9 genetic variants were used to predict the low-density lipoprotein (LDL) cholesterol-lowering effects of medications targeting related molecules. Primary summary-level outcome data for log-estimated glomerular filtration rate (eGFR; creatinine) were provided by the CKDGen Consortium (n = 1,004,040 European) from a meta-analysis of CKDGen and UK Biobank data. We also conducted a separate investigation of summary-level data from CKDGen (n = 567,460, log-eGFR [creatinine]) and UK Biobank (n = 436,581, log-eGFR [cystatin C]) samples. Summary-level MRs using an inverse variance weighted method and pleiotropy-robust methods were performed.Results: Summary-level MR analysis indicated that the LDL-lowering effect predicted genetically by HMGCR variants (50-mg/dL decrease) was significantly associated with a decrease in eGFR (–1.67%; 95% confidence interval [CI], –2.20% to –1.13%). Similar significance was found in results from the pleiotropy-robust MR methods when the CKDGen and UK Biobank data were analyzed separately. However, the LDL-lowering effect predicted genetically by PCSK9 variants was significantly associated with an increase in eGFR (+1.17%; 95% CI, 0.10%–2.25%). The results were similarly supported by the weighted median method and in each CKDGen and UK Biobank dataset, but the significance obtained by MR-Egger regression was attenuated.Conclusion: Genetically predicted HMG-CoA reductase inhibition was associated with low eGFR, while genetically predicted PCSK9 inhibition was associated with high eGFR. Clinicians should consider that the direct effect of different types of lipid-lowering medication on kidney function can vary.
Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management
Authors: Yoo Jeong-Ju , Park Moo Yong , Kim Sang Gyune
Published: May 2023

Acute-on-chronic-liver failure (ACLF) refers to a phenomenon in which patients with chronic liver disease develop multiple organ failure due to acute exacerbation of underlying liver disease. More than 10 definitions of ACLF are extant around the world, and there is lack of consensus on whether extrahepatic organ failure is a main component or a consequence of ACLF. Asian and European consortiums have their own definitions of ACLF. The Asian Pacific Association for the Study of the Liver ACLF Research Consortium does not consider kidney failure as a diagnostic criterion for ACLF. Meanwhile, the European Association for the Study of the Liver Chronic Liver Failure and the North American Consortium for the Study of End-stage Liver Disease do consider kidney failure as an important factor in diagnosing and assessing the severity of ACLF. When kidney failure occurs in ACLF patients, treatment varies depending on the presence and stage of acute kidney injury (AKI). In general, the diagnosis of AKI in cirrhotic patients is based on the International Club of Ascites criteria: an increase of 0.3 mg/dL or more within 48 hours or a serum creatinine increase of 50% or more within one week. This study underscores the importance of kidney failure or AKI in patients with ACLF by reviewing its pathophysiology, prevention methods, and treatment approaches.
STRATEGI PEMBERDAYAAN KORBAN PENYALAHGUNAAN NARKOBA DALAM MENUMBUHKAN KEMANDIRIAN DI WISMA ATARAXIS KABUPATEN LAMPUNG SELATAN
Authors: Rohman Abdul , Achlami HS. MA. , Saifuddin M.
Published: May 2023

Victims of drug abuse face barriers to interaction because of the negative stigma in society, followed by a lack of optimism, a lack of ability to solve problems, a lack of self-confidence, and then drug abusers have negative self-concepts, tending to view themselves as pessimistic about competence. (1) What is the strategy for empowering victims of drug abuse in fostering independence at Wisma Ataraxis, South Lampung Regency? (2) How are efforts to empower drug abuse victims fostering independence at Wisma Ataraxis in South Lampung Regency? (3) How does Wisma Ataraxis, South Lampung Regency, contribute to empowering victims of drug abuse and fostering independence? Field research with a qualitative descriptive approach is used in this study. Field research with a qualitative descriptive approach is used in this study. Data derived from primary and secondary sources, with data collection techniques such as interview, observation, and documentation, as well as data analysis techniques such as data collection, data reduction, data presentation, and conclusions. According to the findings of this study, the empowerment process produces satisfactory results. Victims of drug abuse who are directly involved in the empowerment process benefit more. They believe the skills they have gained will be useful to them. It is also possible to reduce unemployment and increase economic income with this skill training.
Virtual Lab Based on STEM Approach: Is It Effective to Enhance Students Concept of Temperature and Heat?
Authors: Syukri Muhammad , Rahmi Mulia , Saminan Saminan , Artika Wiwit , Subramaniam Tamil Selvan
Published: May 2023

This study aims to create a virtual lab in science-physics learning based on a valid, practical, and effective STEM-based virtual lab for junior high school students. The research was conducted using Research and Development.The research was conducted at SMP Negeri Unggul Tunas Nusa (junior high school). This research was carried out in the even semester of the 2021/2022 academic year. The subjects used in this study were students of class VII Tusa at SMPN Unggul Tunas Nusa in the academic year 2021/2022, totaling 29 students. The sampling technique used is random sampling. Based on the analysis, the average percentage assessment of all aspects is 87.89%, meaning the STEM-based virtual lab product is very feasible. The STEM-based virtual lab is assessed for teachers' and students' use. Practical criteria for teachers and students. The pretest means of student learning outcomes scored 24.57, while the posttest means after being applied to a STEM-based virtual lab scored 84.45. The average score of N-gain student learning outcomes is 0.80, which is high and able to improve student learning outcomes.The results of this study are expected to be used as an alternative for a teacher to improve student learning outcomes.
Konsep Tri Pusat dalam Pendidikan Sekolah Berbasis Pesantren: Memperkuat Dimensi Spiritual, Akademik, dan Sosial
Authors: Muhamad Slamet Yahya
Published: May 2023

This study aims to evaluate the implementation of the Tri Pusat concept in pesantren education at SMK Ma’arif 6 Kebumen and examine its contribution to strengthening the spiritual, academic, and social dimensions of students. A qualitative approach was employed, involving classroom observations, interviews, and document analysis. The findings indicate that SMK Ma’arif 6 Kebumen has successfully implemented the Tri Pusat concept holistically. The spiritual dimension is reinforced through religious instruction and regular religious practices. The academic dimension is emphasized through a comprehensive curriculum and practical learning. Meanwhile, the social dimension is developed through extracurricular activities and community service. The implementation of the Tri Pusat concept benefits students in their spiritual, academic, and social development. Despite challenges in implementation, continuous efforts are made to improve its effectiveness. In conclusion, the implementation of the Tri Pusat concept at SMK Ma’arif 6 Kebumen makes a positive contribution to strengthening the spiritual, academic, and social dimensions of students.
Kachachi’s The American Granddaughter Beyond Victims and Perpetrators of September 11: The Implicated Subject in Inaam
Authors: Kaddah Saad Alqahtani Noorah
Published: May 2023

September 11 events took a heavy toll on many countries, particularly Iraq. Ever since those events, the white American literary and critical responses dominated the mainstream of the 9/11 novel subgenre with a significant focus on the resulting trauma on white Americans. Therefore, this paper seeks to broaden the critical scope of the 9/11 novel subgenre apart from the white American majority by implementing trauma theory to view the impact of 9/11 events on Iraqi people in their homeland as represented in Inaam Kachachi’s (2008) The American Granddaughter. Its significance lies in attempting to decenter the 9/11 trauma by shifting the debate from the ethical and legal accountability of who destroyed whom to foregrounding other sites of injustices that attest to forms of the implication and voice earlier suppressed pains and worries. The main question is how Kachachi, a Paris-based Iraqi novelist, portrayed the 9/11 traumatic aftermath in the novel through the perspective of an Iraqi/American female interpreter who worked for the American army during the Iraq War. Drawing on trauma theory, this study investigates the protagonist’s complex position, which best exemplifies Michael Rothberg’s theory of implication, where a participant in a traumatic experience occupies a position aligned with power and privilege without being a direct agent of harm. This paper finds that the novel contributes to the 9/11 novel counternarratives and confirms the implication of Iraqi/American people during the Iraq War that divulged the silenced personal and collective traumatic narratives spanning several Iraqi generations.
ANALISIS PENAMBAHAN BOTTON ASH TERHADAP KUAT TEKAN DAN KUAT BELAH BETON
Authors: Prasetyo Febri , Herni Mas , Dewi Sari Utama
Published: May 2023

Beton merupakan salah satu bahan kontruksi yang telah banyak digunakan untuk bangunan gedung, jembatan, jalan, dan lain lain. Beton mempunyai peranan sangat penting untuk kontruksi karena mampu menahan gaya tekan dengan baik. Pemakaian beton sudah populer, pada perkembangannya beton dicampuri dengan beberapa bahan tambahan baik berupa bahan kimia maupun non kimia di antaranya, abu Ampas tebu (AAT), Fly Ash, Bottom Ash dan polimer. Penelitian ini bertujuan untuk mengetahui pengaruh tambahan limbah batu bara (bottom ash) terhadap kuat tekan dan kuat tarik belah beton, dengan beberapa variasi tambahan. Pengambilan data atau pengujian sample dilakukan dilaboratorium Universitas Muhammadiyah Metro dengan metode  SK SNI.T-15 -1990 – 03. Dari hasil penelitian yang sudah lakukan, penambahan bottom ash yang ideal adalah pada persentase 9%  karena memiliki kuat tekan dan berat beton yang sesuai rencana. Kuat tekan maksimum yang dapat dicapai dari semua komposisi campuran yang digunakan terdapat pada penambahan bottom ash sebesar 9% pada umur 28. hari dengan nilai kuat tekan 292.144 kg/cm2. Penambahan bottom ash pada persentase 9 % selalu menghasilkan nilai kuat tekan  lebih tinggi dari pada beton normal atau beton tanpa campuran.
Characteristics of molecular interaction in oil dispersed systems
Authors: Pivovarova Nadezhda Anatolievna
Published: May 2023

Oil, gas condensates, oil products present a complex colloidal-dispersed system which often demonstrates the abnormally changing properties when external conditions change. Mixing the petroleum products can be accompanied by a non-linear behavior accompanied by synergistic and antagonistic effects. Understanding of the oil and oil products as oil dispersed systems, the specific features of intermolecular interaction largely clarify their behavior, changes in properties, chemistry and mechanism of reactions occurring in them. Petroleum systems are polydisperse, in which the components can coexist in different aggregate states, and the size of the dispersed phase can vary over a wide range. They consist of diverse compounds that differ in properties, structure, shapes and sizes of molecules. Due to the variety of components that make up oil disperse systems the intermolecular interactions determine such a feature of the behavior of oil systems as the phenomenon of self-organization and structuring, which manifest themselves when external influences change and are sensitive to them. They are characterized by the absence of charge and a minimum of charge-polarization interactions of molecules, and intermolecular interactions are largely determined by the presence of paramagnetic molecules. The uncompensated spin of macromolecular compounds due to the steric obstacles, a homolytic dissociation, and the presence of microelement compounds ensure the paramagnetism of petroleum dispersed systems. This leads to developing the stable associative combinations and the formation of complex structural units capable of redistributing components and layers between phases under the influence of external effects. Comprehensive analysis and unanimity of views on the physical and chemical interactions of the components of oil systems leading to a change in their structure, open up fundamentally new opportunities for intensifying processes in the practice of production, transportation and processing of hydrocarbon raw materials and the use of petroleum products, and also allow predicting the behavior of oil systems in processes which they are participating.
Del valor del templo al Coste del libro. (Las Finanzas de Salomón. El Mecenazgo de Felipe II, y Juan Bautista Villalpando).
Authors: Ramírez Juan Antonio
Published: May 2023

Según la tradición judeocristiana, el Templo de Salomón habría sido diseñado por el mismo Dios, de modo que la obsesión por conocer su estructura y ornamentos, ha conducido a impresionantes tratados teológicos y a notables realizaciones artísticas concretas.
Velázquez, pintor intelectual. La visión emblemática del retrato aúlico
Authors: González Zárate Jesús María
Published: May 2023

Entre los diferentes géneros pictóricos cultivados por Diego Velázquez es sin duda el retrato, a juicio de Martín González, el que más importancia tuvo para el artista.
Los túmulos funerarios de Carlos III y la imagen del Rey en Hispanoamérica y Filipinas
Authors: Morales Folguera José Miguel
Published: May 2023

Si tenemos en cuenta el número de exequias fúnebres, celebradas en todo el Imperio Español por el alma del difunto Carlos III, deberemos entonces admitir que este rey fue uno de los más queridos y apreciados de toda la historia de la monarquía hispana.
Fotografía y archivo
Authors: Argerich Isabel
Published: May 2023

Resumen:El artículo expone la formación de archivos fotográficos ya desde los comienzos de la fotografía, y como las fotografías se incorporan de forma temprana a los archivos con documentación tradicional. Esta pronta y progresiva aportación viene determinada por el desarrollo tecnológico, así como por la difusión del uso y práctica de la fotografía. El texto incluye algunos ejemplos al respecto, insertos en los grandes periodos de evolución de la práctica fotográfica. A continuación aborda las acciones de recuperación de archivos fotográficos, debidas a que la fotografía histórica empieza a considerarse como hecho cultural a finales de la década de 1970. Finalmente menciona la incorporación de la fotografía “de archivo” al mercado del arte, iniciada en esas mismas fechas, así como el surgimiento de la tendencia artística denominada arte de archivo. Abstract: The paper presents the formation of photographic archives since the beginning of photography, and the rapid incorporation with others traditional documentation files. This early and progressive contribution is determined by technological development and diffusion of the use and practice of photography. The text includes some examples of the major periods of evolution of photographic practice. Also discusses actions to recover photo files, due to historical photography began to be considered as a cultural phenomenon in the late 1970s finally mentions the incorporation of photography "file" to the art market, initiated in these same dates as well as the emergence of the artistic movement called “art file”. Palabras clave: Fotografía; archivo; procesos fotográficos; recuperación; valoración; memoria. Keywords: Photography; Archives; Photographic Process; Archives and Memory; Awareness of Photography Images.
Distributions, range extensions and host list update for four phoretic mite genera (Acari: Klinckowstroemiidae) on Passalidae (Coleoptera)
Authors: Schuster Jack , Gygax Daniel , Diaz Dafna L. , Serrano-Peraza Francisco
Published: May 2023

Mites of the family Klinckowstroemiidae are phoretic on passalid beetles in the New World. The family includes 37 species distributed in 4 genera, Klinckowstroemia (28 spp.), Similantennurella (2 spp.), Klinckowstroemiella (5 spp.) y Antennurella (2 spp.). Little is known about the true distribution and species diversity of these genera, especially the latter 3. We examined specimens of Antennurella, Similantennurella and Klinckowstroemiella collected from passalids from several entomological collections. We added Ecuador, French Guyana, Guatemala and Mexico to the distribution range of Similantennurella, Belize, Bolivia, Ecuador, Guatemala, Trinidad and Venezuela for Antenurella, and Bolivia, Ecuador, Honduras and Peru for Klinckowstroemiella. We report 8 new passalid host species previously unknown for these genera. Our study suggests a broad distribution range of the 3 genera, probably encompassing Mesoamerica and South America except Chile and Patagonia, where passalids are not found. Antennurella, Similantennurella and Klinckowstroemiella apparently occur primarily below 1500m altitude, while Klinckowstroemia has been repeatedly found above this limit. All genera have been found mostly on large passalids (>22 mm, long). We also cite the family for the first time from El Salvador.