bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the knowledge level and usage attitudes of the medical students on the medicinal herbs and herbal products: a project of special study module in the first three years of the school of medicine
Authors: Guven Hulya , Kalkan Sule , Hocaoglu Nil , Yildiztepe Engin , Gokalp Gamze
Published: February 2019

Background: In this survey, it was aimed to determine the types of medicinal herbs and herbal products, reasons of use and consciousness levels among the medical students in the first three years of the School of Medicine.Methods: A cross-sectional descriptive questionnaire consisting of 50 questions was applied to all the students in the first three years of Dokuz Eylül University School of Medicine between September 1, 2016 and June 1, 2017.Results: The results of 571 participating students were evaluated. Of these students, 301 (52.7%) were females and 270 (47.3%) were males. It was found that 73.4% (n=419) of the students used these products for treatment and mostly consumed linden, sage tea, mint and rosehip. Also, 11.6% of the students had chronic diseases (n=66). It was determined that 69.7% (n=46) of these students having chronic diseases used medicinal herbs and herbal products. Only 12.0% of the students had an opinion about the legal regulations regarding the use of herbs and herbal products in Turkey, while 39.7% of them had no idea, and 48.3% stated that such regulations on this matter were unreasonable. However, 59.7% of the respondents stated that legal regulations were necessary. It was found that the participating students used herbs and herbal products generally for therapeutic purposes without having sufficient knowledge about medicinal herbs; therefore it was necessary to increase their level of consciousness.Conclusions: Medical students neither have adequate medical information about medicinal herbs and herbal products, nor about the regulations on these products. It is crucial to revise the courses in the medical education so that the students would get informed about the regulations as well as potential risks of herbal plants while still in the medical schools.
METHODOLOGICAL APPROACHES TO DETERMINING THE STATE OF BLOCK SEISMOGENIC MEDIUM ON THE EXAMPLE OF THE 2008-2011 SEISMIC ACTIVATION IN THE CENTRAL PART OF THE BAIKAL RIFT
Authors: Dyadkov P. G. , Romanenko Y. M. , Kozlova M. P. , Tsibizov L. V. , Duchkova A. A.
Published: February 2019

Based on the joint analysis of the seismic regime parameters, such as anomalies of seismic energy release, b-value, seismic activity A10, approaches to assess the state of the block-seismic medium are proposed. The method validation was done for the example of preparation and development of seismic activity in 2008-2011 in the Central part of the Baikal rift, during which there were 2 strong M5.3 earthquakes. It was found that within 2 years before the strong Maximihinskoye Earthquake of 2008 in the Earth's crust of the epicentral region there is a transformation from softening to strengthening (consolidation) of the block medium. At the same time, in the neighboring region (the area of the Svyatoy Nos Peninsula), the opposite nature of the changes is observed.
STRUCTURAL CHARACTERISTICS OF VENDIAN-CAMBRIAN SEDIMENTS WITHIN THE NORTHTUNGUSKA OGR USING SEISMIC 2D DATA IN CONNECTION WITH PETROLEUM POTENTIAL
Authors: Gubin I. A. , Taratenko A. V.
Published: February 2019

Complex interpretation of seismic and parametric drilling data is performed. The data for interpretation are obtained within the conjunction zone of the Kureyka syncline and the Anabar anteclise. As a result of complex interpretation the structural maps on the bottom of Vendian and the top of the Kuonamka formation are constructed. Map of the Vendian terrigenous complex was constructed. High prospects of oil and gas potential of the lower-middle Cambrian sediments are shown. Based on the analysis of logging data, core description and detailed correlation of time sections, the litho-acoustic models were compiled for two profiles crossing the barrier-reef system, and two-dimensional synthetic time sections were calculated. Obtained results confirm the correctness of the ideas about the internal structure of the Vendian-Cambrian complexes.
METHOD OF AUTOMATED EXTRACTING OF DISPERSION CURVES BASED ON TIME-FREQUENCY DISTRIBUTION OF SEISMIC DATAv
Authors: Yablokov A. V. , Serdyukov A. S.
Published: February 2019

The paper discusses the method of multichannel analysis of surface waves. We propose an automated method of surface waves extraction, based on the time-frequency representation of seismograms and their subsequent spatial spectral analysis. This approach is robust for the extraction of smooth and realistic dispersion curves in automatic mode. This provides a more reliable assessment of high-velocity sections of shear waves by the method of multichannel analysis of surface waves. The article presents the results of testing of the developed approach with using noisy synthetic and real seismic data.
Educación transdisciplinar en valores para la integración de jóvenes en riesgo de exclusión social
Authors: Pereira Araujo Anfrisia Alessandra , Plata Luque María del Carmen , Ortiz Mallol María Luisa , Jiménez Durán Ana Isabel
Published: February 2019

El artículo describe la relevancia de la integración de jóvenes de los grupos étnicos gitano y no gitano, en riesgo de exclusión social, utilizando como núcleo central los valores humanos y la transdisciplinaridad. El principal objetivo es la inclusión de la educación en valores en la educación conceptual, intelectual, emocional y práctica del curriculum, de modo que la importancia de los valores trascienda al contexto familiar, social y cultural. A partir de referentes teóricos de la educación, la sociología y la teoría de sistemas (Freire, Bordieu, Morin, Nicolescu) la metodología parte de los modelos que integran paradigmas objetivistas, subjetivistas y crítico. El principal resultado de este enfoque es una formación y una capacitación sistemática en valores en el ámbito de una educación formal inclusiva y participativa.
An Institutional Coordinated Plan for Effective Partnerships to Achieve Health Equity and Biomedical Workforce Diversity
Authors: Vishwanatha Jamboor K. , Basha Riyaz , Nair Maya , Jones Harlan P.
Published: February 2019

The rapid growth and accumulation of specialized knowledge in today’s biomedi­cal fields, combined with entrenched and emerging health issues that persist among certain groups within the US population, emphasizes the significant need to diversify the nation’s biomedical science workforce. The under-representation of minorities in science results in inadequate scientific input from divergent social or cultural perspec­tives and detracts from our nation’s ability to resolve health disparities. The University of North Texas Health Science Center at Fort Worth has developed a coordinated approach with local, regional, and na­tional partners to increase participation of underrepresented students along the career pathway from K-12 to faculty level. Career stage specific activities that include research, mentoring, networking, career development, grantsmanship and health disparities curriculum are provided for participants. Successful outcomes from our coordinated plan includes an increase in participant self-efficacy, research presenta­tion awards, increase in grant awards and publications, and career advancement. Through partnerships within our institution, local school districts, and minority serving institutions nationwide, our coordinated plan provides mutually beneficial co-learning experiences to increase the number of under-represented individuals entering translational research focused on increasing the biomedical research workforce diversity and achieving health equity. Ethn Dis. 2019;29(Suppl2):129-134); doi:10.18865/ed.29.S1.129.
Acute Toxicity of Ethanol Leaves Extracts of Cassava (Manihot esculenta) on Liver Histopathology of Wistar Rats
Authors: Saddamiah Sheillavi Fauziah Alex , Normasari Rena , Abrori Cholis
Published: February 2019

Cassava leaves (Manihot esculenta) contain cyanogenic glylcoside as toxicant. Cyanogenic glycoside can be hydrolized into glucose and cyanohydrin acetone which is then decomposed into cyanide. Cassava leaves are used by the community as a source of food and traditional medicine. However, there is a report of incidents of intoxication and death from cassava consumption in Kenya. This research is intended to know the effect of toxic dose ethanol extract of cassava leaves to liver histopathology of Wistar rats. This study was conducted through two stages, sighting study and main study. Both studies used initial dose level 2000 mg/kg and given once at the first day of each study. Main study consists of two groups, control group given 0,5% Na-CMC and treatment group given ethanol extract of cassava leaves dose 2000 mg/kg. All animals were observed for 14 days. Liver histopathology scores were obtained. Mann Whitney test showed that p= 0,009 (p<0,05) so that can be concluded that ethanol extract of cassava leaves dose 2000 mg/kg can cause histopathological changes in the liver of Wistar rats represented by cloudy swelling degeneration, hydropic degeneration, and necrosis in some cell.
Difference of Right Ventricular Systolic Function Before and After Hemodialysis in Chronic Kidney Disease Stage V In RSD dr. Soebandi Jember
Authors: Mediawati Saskia , Suryono Suryono , Suswati Enny
Published: February 2019

End stage renal disease is a clinical state with an irreversible chronic decreasing function of renal that need a hemodialysis or renal transplant as theraphy. One of the complication of End stage renal disease is cardiovascular. Cardiovascular complication is a major cause of mortality and mobility in End stage renal disease by 44% in Indonesia. Systolic function of right ventricle can be used to assess the heart function. The purpose of this study is to differentiate the systolic function of right ventricle in patient with end stage renal disease in RSD dr. Soebandi Jember. We used analytical observational approach with cross sectional method held at Dialysis and Echocardiography Unit of RSD dr. Soebandi Jember from September to November 2017. Thirty patients with end stage renal disease who routinely undergoes dialysis were observed. Shapiro-Wilk test results 0,000 significance shows that the data is not normally distribute. Wilcoxon test results significance level 0,005 which shows there is a differentiation between before and after hemodialysis of systolic function in end stage renal disease patients of RSD dr. Soebandi Jember. 

 Keywords : End stage renal disease, systolic function on right ventricle, hemodialysis
The Correlation between HIV/AIDS Positive Pregnant Mother with Infant APGAR Score in RSD dr. Soebandi Jember
Authors: Purwaningsih Nurlaila Ayu , Shodikin Muhammad Ali , Abrori Cholis
Published: February 2019

Human Immunodeficiency Virus (HIV) is a virus that decreased immunity and a set symptoms of diseases called Acquired Immune Deficiency Syndrome (AIDS). One of the major risk factors for HIV transmission is perinatal transmission about 2.8% during pregnancy, delivery, and postpartum. HIV positive mothers have a potential to give birth infants with low APGAR. APGAR Score was used as a reference to determine asphyxia in the first and fifth minutes of life. The purpose of this research were to determine the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score and to determine the other factors that affect the infant APGAR Score in RSD dr. Soebandi Jember. This research used observational analytic survey method with cross sectional design using medical record of HIV positive and negative pregnant women from August 2014-July 2017 in RSD dr. Soebandi Jember as a subject that qualify the inclusion and exclusion criteria. This research used case group sampling technique by total sampling and control group by simple random sampling each 52 samples. Test result of the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score using Chi-Square test obtained p value=1.000 (OR=1.13) that means there was no significant correlation. Test result of the correlation between the other factors that affect infant APGAR Score concluded that there were no significant correlation.

Keywords: pregnant mother, HIV/AIDS, APGAR Score, infant
Effects of Murbei Leaf Extract (Morus alba L.) on Malondialdehyde (MDA) Eye Lens in Rats (Rattus novergicus) Cataract Model
Authors: Ulfah Ema Fawziyah , Komariah Cicih , Elfiah Ulfa
Published: February 2019

Cataract is a degenerative disease and one of the leading causes of blindness in Indonesia and in the world. Free radical formation leads to pathological reactions in the lens that can induce lipid peroxidation that produces malondialdehyde (MDA). Mulberry leaf (Morus alba L.) is one of the plants rich in antioxidants. The purpose of this study was to determine the effect and effective dose of mulberry leaf extract on MDA content of eye lens in rats cataract model. This study is true experimental with posttest only control group design. This study used 7 groups, each 5 tails. Normal control groups were not treated. The negative control group induced sodium selenite 25 μmol / kgBW and was given 0.1% HPMC eye drops. The treatment group induced sodium selenite 25 μmol / kgBB and given 0.05%, 0.1%, 0.2%, 0.3% and 0.4% mulberry leaf extract for 14 days. Measurement of MDA lens concentration are using MDA-TBA method. Data analyzed by using one way Anova test showed significant result with value p = 0,000 (p <0,05). Based on the results of this study it can be concluded that mulberry leaf extract has an effect on decreasing MDA lens in rats cataract model. Among the concentrations used, the concentrations that showed the lowest decrease in MDA concentration were 0.4%.Keywords: cataract, sodium selenite, malondialdehid, Morus alba L
The Difference of Plasma Malondialdehyde (MDA) Level in Farmers Using Chemical Pesticides and Farmers Using Organic Pesticides
Authors: Nur Rahmadani Nikmatul Maula , Rachmawati Dwita Aryadina , Elfiah Ulfa
Published: February 2019

Many farmers still use chemical pesticides. Chemical pesticides inside the body will form free radicals that will bind to unsaturated fatty acids (cell membrane structures) that cause increased levels of malondialdehyde (MDA). Organic pesticides can be used as an alternative to control pests. Organic pesticides leave no residues to plants and the environment. This study aims to determine the difference of plasma malondialdehid (MDA) levels in farmers who use chemical pesticides in Dawuhan Village, Tenggarang Subdistrict, Bondowoso Regency and farmers who use organic pesticides in Lombok Kulon Village, Wonosari Sub-district, Bondowoso District. This was an observational analytic research with cross sectional research design conducted on 30 farmers who use chemical pesticides and 30 farmers who use organic pesticides. Blood sampling was taken from Mediana cubiti vein. Measurements of plasma malondialdehyde (MDA) were performed using the TBARS method. Based on the result of Unpaired T-test, it was found that p < 0.001 which showed significant difference in plasma malondialdehyde (MDA) level in farmers using chemical pesticides and farmers using organic pesticides. The plasma malondialdehyde (MDA) level average were higher in farmers using chemical pesticides.

Keywords: Chemical Pesticide, Organic Pesticide, Plasma Malondialdehyde
The Influence Of Using Extract Neem Leaf (Azadirachta indica A.juss) Soap In The Scabies lesions grade II Healing
Authors: Murniati Anis , Rohmawati Indah
Published: February 2019

Scabies is an infectious skin disease caused by infection with Sarcoptes scabiei mites. Clinical symptoms of itching in the lesions. There are herbal plants, namely the neem plant with the content of mimba leaf extract, giving a very good effect in providing resistance to mites in vitro. Mimba leaf processing can be done to make various products, including soap products. So the researchers wanted to develop the concept and knowledge of the effects of soap made from mimba leaf extract in curing lesions in scabies grade II patients in the female dormitory of Ponpes Pandanaran Ngunut Tulungagung. This study uses the Quasy Experiment design with an experimental design of Non equivalent control group design. The treatment group was divided into two treatment groups, namely the treatment using neem leaf extract soap (Azadirachta indica A. juss) and using antibacterial soap. The sample was determined using purposive sampling according to the inclusion criteria, as many as 70 respondents. The assessment used observation sheets of lesion wounds according to the modified Bates-jensen wound assessment tool. The results of the analysis of 70 respondents obtained the results of independent t-test statistics obtained a significance value of p (value) = 0,000. The use of solid soap mimba leaf extract (Azadirachta indica A. juss) in dealing with scabies with Azadirachtinya content which is able to provide resistance to mites by inhibiting the life cycle (metamorphosis).

Keywords: Scabies, neem leaves, lesions, healing
The Larvacidal Activity of Moringa aloifera Extract Leaf to The Larva’s Aedes aegypti Mortality
Authors: Yasi Ratna Mustika , Harsanti Restiani Sih
Published: February 2019

Dengue Hemorrhagic Fever (DHF) is a disease caused by Dengue virus. The disease is spread rapidly in the territory of Indonesia by Aedes aegypti mosquito as the vector. Using Moringa Aloifera leaf extract as a natural larvacide is an attempt to control the disease. This study aims to determine the effect of Moringa Aloifera leaf extract on the mortality of Aedes aegypti larvae. Moringa Aloifera leaf extract is obtained by maceration. The experimental design was divided into negative control groups containing aquades, positive controls containing abate and sample treatment groups. Phytochemical test and UV-Vis spectroscopic quantitative test to identify active compounds. A total of 20 Aedes aegypti larvae were put into a glass containing a solution of distilled water, abate solution and sample solution. Observations are made every 2 hours for 24 hours. The results showed that Moringa leaf extract solution could kill larvae at LC50 3953.17 ppm and LT50 18.98 hours. The mortality rates of larvae at each concentration were 1000 ppm, 5.25 units / 2 hours; 2000ppm, 5.28 units / 2 hours; 3000ppm, 5.91 units / 2 hours; 4000 ppm, 7.18 units / 2 hours, and 5000 ppm 8.63 units / 2 hours. The results showed that Moringa Aloifera leaf extract can kill Aedes aegypti larvae because they contain alkaloids, tannins and flavonoids.Keywords: larvacide, Moringa, Aedes aegypti larvae
Farklı Sosyo-Ekonomik Düzeyde Yer Alan Okullarda Görev Yapan Okulöncesi Öğretmenlerinin Önleyici Boyutta Kullandıkları Stratejilerin Karşılaştırılması
Authors: OCAK KARABAY Şakire , GÜZELDERE AYDIN Damla , ARICI Sena
Published: February 2019

Bu
araştırmada, farklı sosyoekonomik düzeye sahip okullarda görev yapmakta olan
okulöncesi öğretmenlerinin eğitim
ortamlarında kullandıkları önleyici yaklaşım biçimlerinin kuralların
işleyişi, fiziksel ortamın düzenlenmesi, günlük eğitim akışının planlanması
/uygulanması ve olumlu bir sınıf atmosferinin oluşturulması boyutlarında incelenerek karşılaştırılması
amaçlanmaktadır. Araştırmada
çalışma grubu oluşturulurken aykırı durum örneklemesine başvurulmuş ve bu
kapsamda düşük ve yüksek sosyo-ekonomik düzeye sahip olan 2017-2018 eğitim
öğretim yılında İzmir’e bağlı iki merkez ilçede Milli Eğitim Bakanlığı’na bağlı
üç bağımsız anaokulundan 24 okul öncesi öğretmeni ile çalışma yürütülmüştür. Araştırmada veri
toplama aracı olarak “Önleyici Yaklaşımları Değerlendiren Yarı
Yapılandırılmış Öğretmen Görüşme Formu” ve “Öğretmenlerin Önleyici
Yaklaşımlarını Değerlendiren Gözlem Formu” kullanılmıştır. Görüşme yoluyla elde edilen verilerin
analizinde içerik analizine; gözlem yoluyla elde edilen verilerin analizinde
ise betimsel istatistik ile yüzde hesaplamasına başvurulmuştur. Bu çalışmadan elde edilen bulgular değerlendirildiğinde her
iki grupta yer alan öğretmenler arasındaki en temel farklılık fiziksel ortamın
düzenlenmesi boyutunda ortaya çıkmıştır. Ekonomik açıdan desteklenen ve veliler
ile işbirliği içerisinde bulunan okullarda öğretmenlerin bu boyuta yönelik
farkındalık ve uygulamalarının daha yüksek seviyede olduğu saptanmıştır. Olumlu
bir sınıf atmosferinin oluşturulması boyutunda ise öğretmenlerin yetersiz
performans sergiledikleri görülmüştür. Sonuçlar genel olarak
değerlendirildiğinde ise öğretmenlerin önleyici yaklaşıma yönelik uygulamalarda
donanımlarının geliştirilmesine gereksinim olduğu düşünülmektedir.
A Sparse Autoencoder and Softmax Regression based Diagnosis Method for the Attachment on the Blades of Marine Current Turbine
Authors: Zheng Yilai , Wang Tianzhen , Xin Bin , Xie Tao , Tang Tianzhao , Wang Yide
Published: February 2019

The development and application of marine current energy are attracting more and more attention around the world. Due to the hardness of its working environment, it is important and difficult to study the fault diagnosis of a marine current generation system. In this paper, an underwater image is chosen as the fault-diagnosing signal, after different sensors are compared. This paper proposes a diagnosis method based on the sparse autoencoder (SA) and softmax regression (SR). The SA is used to extract the features and SR is used to classify them. Images are used to monitor whether the blade is attached by benthos and to determine its corresponding degree of attachment. Compared with other methods, the experiment results show that the proposed method can diagnose the blade attachment with higher accuracy.
A Hybrid Experimental-Computational Approach to Determine Constitutive Models for Hyperelastic Polymers
Authors: Karimzadeh Atefe , Ayatollahi Majid R. , Razak Bushroa A. , Koloor Seyed S. R. , Yahya Mohd Y. , Tamin Mohd N.
Published: February 2019

A study on the selection of hyperelastic constitutive model for polymeric materials is performed using a hybrid experimental-computational approach. Bis-GMA polymer is used as a case study of hyperelastic material to describe the polymer characteristics by determining its Poisson’s ratio and its valid range of the hyperelastic stress-strain curves. These two parameters are then used to determine the hyperelastic constitutive model by using the hybrid approach. Several uniaxial compression tests along with their finite element simulations are implemented in a systematic way, to identify the polymer behavior under the compressive loading conditions. Nano-indentation experiments are conducted to verify the hyperelastic behavior of the polymer. The experimental and computational evidences confirm that the Poisson’s ratio of Bis-GMA is 0.40 and the appropriate hyperelastic constitutive model for this polymer is of a second order polynomial. It is shown that, the results can be used to determine the true stress-strain curve of hyperelastic materials.
Perpendicular Exchange Bias of Co/Ni mUltilayers Adjacent to Antiferromagnetic FeRh Layer
Authors: Jekal Soyoung , Phoung Dao
Published: February 2019

The perpendicular exchange bias effect is observed in the ferromagnetic Co/Ni multilayers adjacent to the antiferromagnetic FeRh layer. It is found that as the antiferromagnetic FeRh thickness increases from 10 Å to 50 Å, the hysteresis loop is gradually changed from the symmetric shape to the asymmetric shape shifted by some amount corresponding to the exchange-biased field at the thickness of 25 Å. Also, the magnetic domain observation experiment confirms that the domain reversals in the increasing and the decreasing field regions of the sample with the thickness of 50 Å exhibit the same single domain wall motion even though they have the different coercivities.
Therapeutic Approaches with Intravitreal Injections in Geographic Atrophy Secondary to Age-Related Macular Degeneration: Current Drugs and Potential Molecules
Authors: Nebbioso Marcella , Lambiase Alessandro , Cerini Alberto , Limoli Paolo Giuseppe , La Cava Maurizio , Greco Antonio
Published: February 2019

The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called immunomodulatory or anti-inflammatory. A systematic literature search was performed to identify randomized controlled trials published prior to January 2019. Patients affected by dry AMD treated with intravitreal therapeutic agents were included. The changes in the correct visual acuity and the reduction in geographic atrophy progression were evaluated. Several new drugs have shown some promising results, including those targeting the complement cascade and agents called neuroprotective. The action potential of the two groups of drugs is to block the complement cascade model for immunomodulating agents, and prevent the degeneration and apoptosis of ganglion cells for the neuroprotectors, respectively. To the best of knowledge, and after extensive studies on the matter, there are still many investigations to be carried out on dry AMD in collaboration between researchers. They will have to identify truly effective molecules, understand the practical potential of pluripotent stem cells, and refine gene therapies. Only in-depth clinical trials will be able to allow the most appropriate and personalized treatments for each dry AMD patient.
Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis
Authors: Aasen Trond , Sansano Irene , Montero Maria Ángeles , Romagosa Cleofé , Temprana-Salvador Jordi , Martínez-Marti Alexandre , Moliné Teresa , Hernández-Losa Javier , Ramón y Cajal Santiago
Published: February 2019

Direct intercellular communication, mediated by gap junctions formed by the connexin transmembrane protein family, is frequently dysregulated in cancer. Connexins have been described as tumour suppressors, but emerging evidence suggests that they can also act as tumour promoters. This feature is connexin- and tissue-specific and may be mediated by complex signalling pathways through gap junctions or hemichannels or by completely junction-independent events. Lung cancer is the number one cancer in terms of mortality worldwide, and novel biomarkers and therapeutic targets are urgently needed. Our objective was to gain a better understanding of connexins in this setting. We used several in silico tools to analyse TCGA data in order to compare connexin mRNA expression between healthy lung tissue and lung tumours and correlated these results with gene methylation patterns. Using Kaplan-Meier plotter tools, we analysed a microarray dataset and an RNA-seq dataset of non-small cell lung tumours in order to correlate connexin expression with patient prognosis. We found that connexin mRNA expression is frequently either upregulated or downregulated in lung tumours. This correlated with both good and poor prognosis (overall survival) in a clear connexin isoform-dependent manner. These associations were strongly influenced by the histological subtype (adenocarcinoma versus squamous cell carcinoma). We present an overview of all connexins but particularly focus on four isoforms implicated in lung cancer: Cx26, Cx30.3, Cx32 and Cx43. We further analysed the protein expression and localization of Cx43 in a series of 72 human lung tumours. We identified a subset of tumours that exhibited a unique strong nuclear Cx43 expression pattern that predicted worse overall survival (p=0.014). Upon sub-stratification, the prognostic value remained highly significant in the adenocarcinoma subtype (p=0.002) but not in the squamous carcinoma subtype (p=0.578). This finding highlights the importance of analysis of connexin expression at the protein level, particularly the subcellular localization. Elucidation of the underlying pathways regulating Cx43 localization may provide for novel therapeutic opportunities.
Assessment of Sea Level Rise at West Coast of Portugal Mainland and Its Projection for the 21st Century
Authors: Antunes Carlos
Published: February 2019

Data collected at the Cascais tide gauge, located on the west coast of Portugal Mainland, have been analyzed and sea level rise rates have been updated. Based on a bootstrapping linear regression model and on polynomial adjustments, time series are used to calculate different empirical projections for the 21st century sea level rise, by estimating the initial velocity and its corresponding acceleration. The results are consistent to an accelerated sea level rise, showing evidence of a faster rise than previous century estimates. Based on different numerical methods of second order polynomial fitting, it is possible to build a set of projection models of relative sea level rise. Appling the same methods to regional sea level anomaly from satellite altimetry, additional projections are also built with good consistency. Both data sets, tide gauge and satellite altimetry data, enabled the development of an ensemble of projection models. The relative sea level rise projections are crucial for national coastal planning and management since extreme sea level scenarios can potentially cause erosion and flooding. Based on absolute vertical velocities obtained by integrating global sea level models, neo-tectonic studies and permanent Global Positioning System (GPS) station time series, it is possible to transform relative into absolute sea level rise scenarios, and vice-versa, allowing the generation of absolute sea level rise projection curves and its comparison with already established global projections. The sea level rise observed at the Cascais tide gauge has always shown a significant correlation with global sea level rise observations, evidencing relatively low rates of composed vertical land velocity from tectonic and post-glacial isostatic adjustment, and residual synoptic regional dynamic effects rather than a trend. An ensemble of sea level projection models for the 21st century is proposed with its corresponding probability density function, both for relative and absolute sea level rise for the west coast of Portugal Mainland.
The Techno-Economic Potential of Offshore Wind Energy with Optimized Future Turbine Designs in Europe
Authors: Caglayan Dilara Gulcin , Ryberg Severin , Heinrichs Heidi , Linßen Jochen , Stolten Detlef , Robinius Martin
Published: February 2019

Renewable energy sources will play a central role in the sustainable energy systems of the future. Scenario analyses of such hypothesized energy systems require sound knowledge of the techno-economic potential of renewable energy technologies. Although there have been various studies concerning the potential of offshore wind energy, higher spatial resolution, as well as the future design concepts of offshore wind turbines, has not yet been addressed in sufficient detail. Here, we aim to overcome this gap by applying a high spatial resolution to the three main aspects of offshore wind potential analysis, namely ocean suitability, the simulation of wind turbines and cost estimation. A set of constraints is determined that reveal the available areas for turbine placement across Europe’s maritime boundaries. Then, turbine designs specific to each location are selected by identifying turbines with the cheapest levelized cost of electricity (LCOE), restricted to capacities, hub heights and rotor diameters of between 3-20 MW, 80-200 m and 80-280 m, respectively. Ocean eligibility and turbine design are then combined to distribute turbines across the available areas. Finally, LCOE trends are calculated from the individual turbine costs, as well as the corresponding capacity factor obtained by hourly simulation with wind speeds from 1980 to 2017. The results of cost-optimal turbine design reveal that the overall potential for offshore wind energy across Europe will constitute nearly 8.6 TW and 40.0 PWh at roughly 7 €ct kWh-1 average LCOE by 2050. Averaged design parameters at national level are provided in an appendix.
Home Automation (Monitoring Terang Redup Lampu Dan Kontrol Tirai Jendela) Berbasis Node MCU Dan Android
Authors: Triyono Liliek
Published: February 2019

Light Monitoring Dimmed Lights and Curtain Control Windows Node-based MCU is a system designed to turn on and off lights using android controls. In addition the system is also equipped with features open and close the window curtain automatically. This feature and traffic use the LDR sensor to detect light and make it up to 300 then the servo motor will move and open the window. In addition to control android applications, this is in accordance with the function of this system is to control whether the lights are in a state of light or not. You can use remote lights in accordance with the conditions desired by the home owner on android device. This system is used to explore issues related to energy and home safety.
Implementasi Penawaran Produk Toko Online KPRI UNS Dengan Metode AHP TOPSIS
Authors: Purbayu Agus , Nur Amar Abdurrafi
Published: February 2019

Online store KPRI UNS Surakarta is a web-based information that is used to sell goods at the shop KPRI UNS Surakarta. Difficult in the sale of goods because there is no supply of goods in accordance with the criteria. So that the required in accordance with the criteria of members with AHP-TOPSIS method..

The metodology conducted to design and make information system online shop KPRI UNS Surakarta is used waterfall metodology is data collection, the system analysis(determine the functional and non functional requirement), system design (erd, use case diagram, use case text, sequence diagram, and class diagram), and implementation (coding and testing). Information system online shop
Online store information system KPRI UNS Surakarta is able to manage data and using it to offering product. This Offering help by Desission Suport Sistem which Method is AHP Topsis.
CommunityRx: A Real-World Controlled Clinical Trial of a Scalable, Low-Intensity Community Resource Referral Intervention
Authors: Lindau Stacy Tessler , Makelarski Jennifer A. , Abramsohn Emily M. , Beiser David G. , Boyd Kelly , Chou Chiahung , Giurcanu Mihai , Huang Elbert S. , Liao Chuanhong , Schumm L. Philip , Tung Elizabeth L.
Published: February 2019

Objectives. To test the effect of CommunityRx, a scalable, low-intensity intervention that matches patients to community resources, on mental health-related quality of life (HRQOL) (primary outcome), physical HRQOL, and confidence in finding resources.

Methods. A real-world trial assigned publicly insured residents of Chicago, Illinois, aged 45 to 74 years to an intervention (n = 209) or control (n = 202) group by alternating calendar week, December 2015 to August 2016. Intervention group participants received usual care and an electronic medical record–generated, personalized list of community resources. Surveys (baseline, 1-week, 1- and 3-months) measured HRQOL and confidence in finding community resources to manage health.

Results. At 3 months, there was no difference between groups in mental (–1.03; 95% confidence interval [CI] = −3.02, 0.96) or physical HRQOL (0.59; 95% CI = −0.98, 2.16). Confidence in finding resources was higher in the intervention group (odds ratio = 2.08; 95% CI = 1.18, 3.63); the effect increased at each successive time point. Among intervention group participants, 65% recalled receiving the intervention; 48% shared community resource information with others.

Conclusions. CommunityRx did not increase HRQOL, but its positive effect on confidence in finding resources for self-care suggests that this low-intensity intervention may have a role in population health promotion.

Trial Registration. ClinicalTrials.gov Identifier: NCT02435511.
Ethical Acceptability of Reducing the Legal Blood Alcohol Concentration Limit to 0.05
Authors: Morain Stephanie , Largent Emily
Published: February 2019

Twenty-nine Americans die in alcohol-impaired driving crashes daily. The National Academies of Sciences, Engineering, and Medicine released a report that identified strategies to reduce alcohol-impaired driving deaths. One strategy suggests amending state laws to reduce the legal blood alcohol concentration (BAC) limit from 0.08 to 0.05.

Although BAC 0.05 laws would likely reduce alcohol-related deaths, they are also controversial. Critics object to these laws because they restrict individual liberty and fail to consider that individuals value social drinking.

We explored the ethical acceptability of BAC 0.05 laws. We made an ethical argument in support of BAC 0.05 laws, which include preventing harm to both drinking drivers and to others. We then considered and rejected liberty-based objections to BAC 0.05 laws. We concluded that BAC 0.05 laws are not only ethically defensible but desirable. States and Congress should work to promote them.
Identifying Chicago’s High Users of Police-Involved Emergency Services
Authors: Tentner Andrea Ruth , Spellman Amy , Paulson Allison , Day Cameron , Sadler Tonie , Coffman Ruth , Pollack Harold A.
Published: February 2019

Objectives. To identify individuals at risk for behavioral health (BH)–involved encounters with police in Chicago, Illinois.

Methods. We linked Chicago Police Department (CPD) arrest and Fire Department (CFD) BH-involved ambulance event data. We identified at-risk individuals who accumulated at least 1 BH-involved ambulance and at least 1 arrest event between May 2016 and April 2017. We identified a high-use subgroup displaying most intensive services use. We identified high-use locations with highest volume of ambulance events with only CFD data.

Results. Of 83 392 individuals and 116 105 events in the linked emergency events data, 1842 at-risk individuals accounted for 2.2% of individuals, 5.6% of all events, and 16% of BH-involved CFD events with police involvement. A total of 330 high-use individuals accounted for 0.4% of individuals, 2% of events, and 4.7% of CFD events with police involvement. Top-100 high-use locations accounted for 9% of CFD events, and individuals of high-use location events are largely distinct from high-use individuals.

Conclusions. Integrated police and ambulance data hold promise to identify individuals at risk for BH-involved encounters with police and to support proactive interventions to prevent or improve response at these encounters.
Paradoxical Impact of a Patient-Handling Intervention on Injury Rate Disparity Among Hospital Workers
Authors: Sabbath Erika L. , Yang Jie , Dennerlein Jack T. , Boden Leslie I. , Hashimoto Dean , Sorensen Glorian
Published: February 2019

Objectives. To test whether a comprehensive safe patient-handling intervention, which successfully reduced overall injury rates among hospital workers in a prior study, was differentially effective for higher-wage workers (nurses) versus low-wage workers (patient care associates [PCAs]).

Methods. Data were from a cohort of nurses and PCAs at 2 large hospitals in Boston, Massachusetts. One hospital received the intervention in 2013; the other did not. Using longitudinal survey data from 2012 and 2014 plus longitudinal administrative injury and payroll data, we tested for socioeconomic differences in changes in self-reported safe patient-handling practices, and for socioeconomic differences in changes in injury rates using administrative data.

Results. After the intervention, improvements in self-reported patient-handling practices were equivalent for PCAs and for nurses. However, in administrative data, lifting and exertion injuries decreased among nurses (rate ratio [RR] = 0.64; 95% confidence interval [CI] = 0.41, 1.00) but not PCAs (RR = 1.10; 95% CI = 0.74,1.63; P for occupation × intervention interaction = 0.02).

Conclusions. Although the population-level injury rate decreased after the intervention, most improvements were among higher-wage workers, widening the socioeconomic gap in injury and exemplifying the inequality paradox. Results have implications for public health intervention development, implementation, and analysis.
The Mobilization of Splenic Reservoir Myeloid-Derived Suppressor Cells in Sepsis-Induced Myocardial Injury
Authors: Fu Cong , Xu Qiancheng , Tang Shengxing , Cao Yuhan , Liu Can , Li Juan , Wang Yihua , Qian Yan , Shi Fei , Gui Jingmin , Fan Qun , Ling Yang
Published: February 2019

Background

Myeloid-derived suppressor cells (MDSCs) play key roles in sepsis, but whether bone marrow is considered the only source remains unclear. The current knowledge about the mechanism of MDSCs leading to myocardial injury in sepsis is poor.

Methods

In sepsis patients with cardiac dysfunction, the circulating percentage of CD14-CD11b+ and serum concentrations of IL-6 and IL-1β were measured. A mouse sepsis model was established through caecum ligation and puncture (CLP). Animals were divided into four groups: control, sham, CLP and CLP+splenectomy (CLPS). Plasma concentrations of IL-6, IL-1β, TnI and NT-proBNP were measured. CD11b+Gr-1+ cells were detected by immunofluorescence staining and RT-PCR. Myocardial injury was detected by HE, Masson and TUNEL staining. The expression of mTOR, P53 and caspase-3 was measured by Western blot.

Results

In sepsis patients, circulating MDSCs were increased, and the plasma concentrations of IL-6 and IL-1β were elevated. The plasma concentrations of IL-6 and IL-1β were correlated with the ratio of circulating MDSCs. In the mouse sepsis model, the spleen was the major source of CD11b+Gr-1+ cells that migrated into circulation and the heart in sepsis. The serum concentrations of IL-6 and IL-1β were also elevated. Echocardiography and serum biomarkers showed that cardiomyocyte damage and cardiac hypofunction in sepsis induced myocardial imjury. The expression of CD11b, Gr-1 and pro-inflammatory cytokines in the heart was significantly higher in sepsis patients than that in controls. Pathological staining and TUNEL staining showed obvious myocardial damage and cell apoptosis. The Western blot analysis indicated that in the heart, the activation of mTOR was inhibited and that the expression of P53 and caspase-3 was elevated in sepsis-induced myocardial injury.

Conclusion

In sepsis-induced myocardial injury, splenic reservoir CD11b+Gr-1+ cells rapidly migrated into circulation and the heart, further impairing heart function via the high expression of P53 through the inhibition of mTOR.
Reasons of cancellation of elective surgical cases at the University Medical Center
Authors: Viderman Dmitriy , Zhumadilov Agzam , Umbetzhanov Yerlan , Ben-David Bruce
Published: February 2019

Background

Cancellation of scheduled cases on the day of surgery leads to waste of resources, financial burden, patient dissatisfaction, extended hospital stay, and unnecessary repetition of preoperative preparations. The purpose of this retrospective study was to analyze the causes of case cancellation in our institution so as to improve hospital quality control as well as perioperative risk management.

Methods

We conducted a retrospective analysis of all cancellations of scheduled elective surgical procedures. We analyzed all cases that were canceled after the patient had been delivered to the operating room (OR). The data about case cancellations was obtained from the Hospital Information System (HIS) of the National Research Oncology and Transplantation Center.

Results

The most common single reason for cancellation was preoperative hypertensive crisis (n=67; 80.7%), followed by heart rhythm disorders (n=6; 7.2%), incomplete preoperative patient evaluation (n=5; 6.1%), myocardial ischemia (n=4; 4.8%), and pneumonia (n=1; 1.2%). Most of the cancellations (76 out of 83; 92%) were considered to be potentially avoidable.

Conclusions

In conclusion, that the most common reasons for case cancellation were patient-related cardiovascular conditions (preoperative hypertensive crisis, dysrhythmia, myocardial ischemia). Improvement in preoperative assessment and management of the cardiovascular condition is needed to reduce scheduled case cancellation rate.
Changes in the Retinal Blood Flow after an Acute Intraocular Pressure Elevation Observed by Optical Coherence Tomography Angiography
Authors: Ma Ziwei , Qiu Wen-han , Yang Dan-ni Zhou Wei-hua , Pan Xue-feng , Chen Hong
Published: February 2019

Background:Although the pathogenesis of glaucoma is not fully understood ,an elevated intraocular pressure (IOP) is a major factor contributing to its development and progression. The aim of this study was to investigate the changes in the retinal blood flows of the macula and optic nerve head (ONH) after an acute elevation in the intraocular pressure (IOP) observed using optical coherence tomography angiography (OCTA).
Methods: This was a prospective comparative study of subjects with narrow anterior chamber angles who underwent laser peripheral iridotomies (LPIs). The IOP was measured before and one hour after the LPI. The retinal blood flows of the macula and ONH were measured using OCTA at the baseline and one hour after the LPI.
Results: A total of 64 eyes of 51 individuals were enrolled in this study, and 58 eyes of 43 individuals finally completed the study with a mean IOP rise of 10.5 ± 7.6 mmHg after the LPI. Based on the magnitude of the rise in the IOP, we divided the subjects into three groups: group A = IOP rise ≤ 10 mmHg, group B = 10 mmHg < IOP rise ≤ 20 mmHg, and group C = IOP rise > 20 mmHg. The vessel density did not differ after the acute IOP elevation in either the macular region or papillary region in group A or group B (p > 0.05), but there was a significant difference in group C (p < 0.05). However, when the subjects were not separated into groups, the vessel densities of the ONH and macular region did not differ between the measurements obtained at the baseline and one hour after the LPI (p>0.05).
Conclusion: In these normal subjects, an acute mild or moderate IOP elevation for one hour after the LPI did not affect the blood flow in the macula or ONH, as examined using OCTA. However, when the IOP rise was greater than 20 mmHg, the macular and papillary blood flows decreased significantly.
Status of the Muon g-2 experiment at Fermilab
Authors: Driutti Anna
Published: February 2019

The aim of the Muon g-2g−2
Experiment at Fermilab (E989) is to measure the muon anomalous magnetic
moment (a_\muaμ)
with a relative precision of 140 parts-per-billion (ppb). This
precision, which is a factor of four improvement from the current
experimental result, will allow for a much more stringent test of the
Standard Model. This paper present the current status of the
experimental measurement of a_\muaμ
after the first physics run.