bluuebunny/crossref_metadata_2025 huggingface dataset:
Metastatic Breast Cancer, Organotropism and Therapeutics: A Review
Authors: Waza Ajaz Ahmad , Tarfeen Najeebul , Majid Sabhiya , Hassan Yasmeena , Mir Rashid , Rather Mohd Younis , Shah Naseer Ue Din
Published: August 2021

The final stage of breast cancer involves spreading breast cancer cells to the vital organs
like the brain, liver lungs and bones in the process called metastasis. Once the target organ is overtaken
by the metastatic breast cancer cells, its usual function is compromised causing organ dysfunction
and death. Despite the significant research on breast cancer metastasis, it’s still the main
culprit of breast cancer-related deaths. Exploring the complex molecular pathways associated with
the initiation and progression of breast cancer metastasis could lead to the discovery of more effective
ways of treating the devastating phenomenon. The present review article highlights the recent
advances to understand the complexity associated with breast cancer metastases, organotropism
and therapeutic advances.
Comprehensive Account on the Synthesis of (-)-Balanol and its Analogues
Authors: Ahmad Sajjad , Akhtar Rabia , Zahoor Ameer Fawad
Published: August 2021

Background:

A variety of diseases have been associated with hyperactivation of
protein kinase C (PKC) enzymes such as cancer, diabetes, asthma, cardiovascular and central
nervous system disorders. There is a dire need to selectively inhibit these enzymes by
synthesizing new potent inhibitors. Balanol, a fungal metabolite belonging to the PKC inhibitor
family, is especially included in this aspect. Tremendous effort has been put towards the
synthesis of balanol by different research groups.

Objective:

The aim of this review is to provide a detailed description of synthetic approaches
adopted for the synthesis of key fragments of balanol (azepane and benzophenone). All the
factors that resulted in excellent yield and high enantioselectivity have also been mentioned.

Conclusion:

It has been shown throughout this review that the synthesis of hexahydroazepine
and benzophenone cores of balanol was achieved by employing a variety of important key steps
with commercially available starting precursors, which make this total synthesis more valuable.
Moreover, this article provides ideas to the synthetic as well as pharmaceutical chemists for the
synthesis of (-)-balanol and its analogues.
Type 2 Diabetes Mellitus with Early Dry Skin Disorder: A Comparison Study Between Primary and Tertiary Care in Indonesia
Authors: Legiawati Lili , Bramono Kusmarinah , Indriatmi Wresti , Yunir Em , Pratama Aditya Indra
Published: August 2021

Background:

The prevalence of type 2 diabetes mellitus (T2DM) in Indonesia has continued
to increase over the years. Management of T2DM is challenging across clinical settings, including
primary and tertiary care. Uncontrolled T2DM puts patients at risk of the development of
T2DM complications, especially early-stage dry skin that is neglected by most of the patients. This
study aimed to investigate the comparison between the T2DM management profile and dry skin
clinical profile of T2DM patients in primary care and tertiary care settings.

Methods:

The study was conducted as a cross-sectional epidemiological study by comparing
T2DM patient profiles in primary and tertiary care. The data collected included sociodemographic,
clinical, and laboratory data that were correlated with T2DM and early dry skin related-T2DM.
This study included early dry skin within the SRRC score of 3-11 and excluded infection, ulcer,
and severe erythema.

Results:

The patients in primary and tertiary care presented poorly controlled T2DM with median
HbA1c levels of 7.8% and 7.6%. The patients in primary care also presented with high triglyceride,
179 mg/dl. Furthermore, several significant differences were found in the duration of T2DM, duration
of dry skin, and DM treatment (OAD and insulin).

Conclusions:

Significant differences in the duration of T2DM, duration of dry skin, and DM treatment
(OAD and insulin) might be affected by the parameter of T2DM glycemic control (Blood
pressure (BP), body mass index (BMI), HbA1c, random blood glucose (RBG), and triglyceride).
Structural Bioinformatics Used to Predict the Protein Targets of
Remdesivir and Flavones in SARS-CoV-2 Infection
Authors: Speranta Avram , Manoliu Laura , Sogor Catalina , Mernea Maria , Seiman Corina Duda , Seiman Daniel Duda , Chifiriuc Carmen
Published: August 2021

Background:

During the current SARS-CoV-2 pandemic, the identification of effective
antiviral drugs is crucial. Unfortunately, no specific treatment or vaccine is available to date.

Objective:

Here, we aimed to predict the interactions with SARS-CoV-2 proteins and protein targets
from the human body for some flavone molecules (kaempferol, morin, pectolinarin, myricitrin, and
herbacetin) in comparison to synthetic compounds (hydroxychloroquine, remdesivir, ribavirin, ritonavir,
AMD-070, favipiravir).

Methods:

Using MOE software and advanced bioinformatics and cheminformatics portals, we conducted
an extensive analysis based on various structural and functional features of compounds, such
as their amphiphilic field, flexibility, and steric features. The structural similarity analysis of natural
and synthetic compounds was performed using Tanimoto coefficients. The interactions of some
compounds with SARS-CoV-2 3CLprotease or RNA-dependent RNA polymerase were described
using 2D protein-ligand interaction diagrams based on known crystal structures. The potential targets
of considered compounds were identified using the SwissTargetPrediction web tool.

Results:

Our results showed that remdesivir, pectolinarin, and ritonavir present a strong structural
similarity which may be correlated to their similar biological activity. As common molecular targets
of compounds in the human body, ritonavir, kaempferol, morin, and herbacetin can activate multidrug
resistance-associated proteins, while remdesivir, ribavirin, and pectolinarin appear as ligands for
adenosine receptors.

Conclusion:

Our evaluation recommends remdesivir, pectolinarin, and ritonavir as promising anti-
SARS-CoV-2 agents.
Distribution, Metabolism, Excretion and Toxicokinetics of Vitexin in Rats
and Dogs
Authors: He Yuqi , Jiang Min , Cheng Long , Tan Daopeng , Li Geng , Lv Wenying , Shao Xu , Li Xiaoliang , Niu Haijun , Xu Yaoqing , Zhang Jianyong , Qin Lin
Published: August 2021

Background:

Vitexin is the main bioactive compound of hawthorn (Crataegus pinnatifida),
a famous traditional Chinese medicine, and vitexin for injection is currently in phase I clinical
trial in China.

Objective:

This investigation systematically evaluated the metabolism and toxicokinetics of vitexin
in rats and dogs.

Methods:

Rats and beagle dogs were administrated different doses of vitexin, and then the plasma
concentration, tissue distribution, excretion, metabolism, pharmacokinetics and plasma protein
binding were investigated.

Results :

The elimination half-life (t1/2) values in rats after a single intravenous dose of 3, 15 and 75
mg/kg were estimated as 43.53±10.82, 22.86±4.23, and 21.17±8.64 min, and the values of the area
under the plasma concentration-time curve (AUC0→∞) were 329.34±144.07, 974.79±177.27, and
5251.49±786.98 mg•min/L, respectively. The plasma protein binding rate in rats was determined
as about 65% by equilibrium dialysis after 72 hr. After 24 hr of intravenous administration,
16.30%, 3.47% and 9.72% of the given dose were excreted in urine, feces and bile, respectively.
The metabolites of the vitexin were hydrolyzed via deglycosylation. The pharmacokinetics of dogs
after intravenous administration revealed t1/2, AUC0-∞ and mean residence time (MRT0-∞) values of
20.43±6.37 min, 227.96±26.68 mg•min/L and 17.12±4.33 min, respectively. The no-observed-adverse-
effect level (NOAEL) was 50 mg/kg body weight/day. There was no significant accumulation
effect at 8 or 20 mg/kg/day in dogs over 92 days of repeated administration. For the 50 mg/kg/-
day dose group, the exposure (AUC, Cmax) decreased significantly with prolonged administration.
This trend suggests that repeated administration accelerates vitexin metabolism.

Conclusion:

The absorption of vitexin following routine oral administration was very low. To improve
the bioavailability of vitexin, the development of an injectable formulation would be a suitable
alternative choice.
Prevalence of Gastro-esophageal Reflux Disease in Suspected Laryngo-
pharingeal Reflux Unresponsive to Proton-pump Inhibitors
Authors: Tursi Antonio , Palieri Antonio Pio , Tiano Michele , Elisei Walter
Published: August 2021

Background:

Laryngopharyngeal Reflux (LPR) may be part of Gastroesophageal Reflux
Disease (GERD). However, sometimes suspected LPR seems refractory to Proton Pump Inhibitors
(PPI), questioning therefore the GERD diagnosis. Our aim was to evaluate the real-life prevalence
of GERD in patients with a recent laryngoscopic diagnosis of LPR, and unresponsive to PPI.
We also assessed whether other causes than GERD could explain the laryngoscopic findings in
those patients.

Methods:

We retrospectively analyzed patients with the diagnosis of LPR, and unresponsive to
PPI. Those patients must have been investigated by: upper gastrointestinal endoscopy with biopsies;
multichannel intraluminal impedance and pH monitoring (MII-pH); X-ray of the chest and/or
of the paranasal sinuses; hormonal thyroid assessment; prick tests to assess food and/or inhalants
and pollen allergy.

Results:

We enrolled 28 patients (18, 64.3%, males and 10, 35.7%, females; median, IQR age 39.4,
21-75 yrs). Endoscopic hiatal hernia was found in 9/28 (32.1%) patients; the MII-pH analysis
showed abnormality in 2/28 (7.14%) patients (both having also GERD symptoms); Chest X-ray
found chest diseases in 2/28 (7.14%) patients and X-rays of the paranasal sinuses found sinusitis in
1/28 (3.6%); 2/28 (7.14%) patients had hyperthyroidism; food and/or inhalants and pollen allergy
was found in 9 (32.1%) patients. In 12/28 (42.9%) patients, any of the investigated diseases was
found.

Conclusions:

This study found that the real prevalence of GERD in patients with a recent laryngoscopic
diagnosis of LPR, and unresponsive to PPI, is low. Moreover, more than 40% of them did
not show any of the investigated diseases in real life.
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure
Authors: Sharma Amit Raj , Batra Gitika , Saini Lokesh , Sharma Saurabh , Mishra Abhishek , Singla Rubal , Singh Ashutosh , Singh Rahul Soloman , Jain Ashish , Bansal Seema , Modi Manish , Medhi Bikash
Published: August 2021

:

Autism spectrum disorder (ASD) is a composite disorder of brain development with uncertain etiology and pathophysiology. Genetic factors are important in ASD causation, although environmental factors are also involved in ASD pathophysiology. Environmental factors might affect the genetic processes of brain development through the modulation of molecular pathways that might be involved with ASD. Valproic acid and propionic acid are the major environmental factors that serve as medicine and food preservative. VPA is used as an anti-epileptic medicine, but it has adverse effects on pregnant women and alters the developmental patterns of the embryo. It is a multi- targeting agent and affects 5-HT, GABA, etc. PPA is a secondary metabolite of gut microbiota that is commonly used as a food preservative. PPA plays a significant role in ASD causation by altering the several developmental molecular pathways like PTEN/Akt, mTOR/Gskβ, Cytokines activated pathways, etc., at the prenatal and neonatal stage. Moreover, ASD complexity might be increased by other important factors like vitamin A deficiency. Vitamin A is important for cortical brain development and neuronal cell differentiation. Additionally, several important genes such as RELN, Lhx2, CREB, IL-6, NMDA, BDNF, etc., are also altered in ASD and involved in brain development, central nervous system, and enteric nervous system. These genes affect neuronal differentiation, hyperactivity, oxidative stress, oxytocin, and GABA imbalance lead to improper behavior in autistic individuals. These genes are also studied in VPA and PPA ASD-like animal models. In this review, we explored the mechanical pathways that might be altered with VPA and PPA exposures at the embryonic developmental stage or neonatal developmental stage.
Analysis of Information Technology Security Management UKSW SIASAT Using ISO/IEC 27001:2013
Authors: Tanaamah Andeka Rocky , Indira Friska Juliana
Published: August 2021

IT security management is essential for organizations to notice the occurring risks and opportunities because they will profoundly affect the ongoing business processes within the organization. The Satya Wacana Academic Information System, more often called SIASAT, is an IT component playing an essential role in running core business processes at Satya Wacana Christian University under the control of the Information Systems and Technology Bureau. At this time, the implementation of SIASAT has been going well, but there are still some obstacles. Lack of human resources is one of the findings and one it becomes of the most significant risks as it affects the use of infrastructure and information security. This research was conducted using the international standard ISO/IEC 27001:2013, prioritizing information security by taking a planning clause focusing on risk assessment. From the results of this study, there were nine recommendations given. Some of which were the most important, i.e., creating separated standard operating procedure documents for SIASAT, which previously were still affiliated with the Academic Administration Bureau; distributing job descriptions; and providing clear and documented access rights for everyone. It is expected that this research can reduce the occurring risks and can be considered for establishing improvements to enhance academic services in the future.
Ultra-Wideband Microstrip Bandpass Filter and Its Equivalent Circuit
Authors: Nurjihan Shita Fitria , Rafsyam Yenniwarti
Published: August 2021

Microstrip filters can be designed with various methods to obtain good performances, such as defected ground structure, open-ended slot, planar edge coupled, and split ring resonator with groundplane windowing. In this paper, the design of an ultra-wideband microstrip bandpass filter used the defected ground structure (DGS) method by adding a circular slot to the groundplane. The addition of the circular slot was carried out to improve the value of S parameter (return loss and insertion loss) from the initial filter design without a circular slot. In the simulation process, optimization was carried out by changing the value of filter component parameters such as patch length and thickness and circular slot width. The simulation results showed that the microstrip bandpass filter could pass frequencies in the range of 1.4 GHz to 5.7 GHz with the bandwidth response of 4.3 GHz. In addition, filter analysis could also be done with an equivalent circuit represented by lumped element components in the form of capacitors and inductors connected in series or parallel. The simulation results of the equivalent circuit had a wider bandwidth, which was able to pass frequencies in the range of 1.2 GHz to 6.1 GHz with a bandwidth response of 4.9 GHz.
The Importance of the Lexical Paradigm of Pretext Assessment for the Formation of a Parody
Authors:   H. S. Skovoroda Kharkiv National Pedagogical University, Vorobiova Olha
Published: August 2021

The article deals with transforming the primary text into a parody - the introduction of the paradigm of critical assessment of pretext into the primary text. This paradigm is derived using the paradigmatic analysis of vocabulary, highlighting the means of the text that form a specific system of images for the reader. Parody is of particular interest for the paradigmatic analysis of vocabulary since it refers to the so-called secondary texts - texts created on the material of other texts, already available. When creating a secondary text, various elements are borrowed from the original text, such as lexemes, phrases, etc., and lexical paradigms that undergo various transformations in the secondary text. However, a paradigm in parody is inherent exclusively in texts of this type - the paradigm of critical assessment of the pretext. A critical assessment of the pretext is extremely important for forming a parody since one of its main distinguishing features is controversial to the original text. To study the role of the critical appraisal paradigm, we took parodies of A. Ivanov on the verses of E. Yevtushenko. The study of this material has shown that the paradigm of critical assessment of the pretext is inherent exclusively in parodies and is used to form the effect of distancing the reader from the original text; pretext begins to be perceived not as a text itself, but as an object for outside consideration and criticism. The explicitly expressed paradigm of critical assessment of the pretext can also be accompanied by the paradigm of comic reduction, which forms a comic effect in parody, but this paradigm in the text is optional. On the other hand, critical assessment in the text is obligatory since it is due to this paradigm that polemic is formed, obligatory for parodic texts.
Comentario del “caso Bonilla”
Authors: González Oropeza Manuel
Published: August 2021

El presente analisis se desprende de la decision en pleno de la Suprema Corte de Justicia de la Nación, que  declaró inconstitucional esta ley conocida como “Ley Bonilla”.
Interpretación, argumentación y control de convencionalidad
Authors: Castellanos Hernández Eduardo de Jesús
Published: August 2021

El presente artículo busca reunir algunos conceptos para la mejor comprensión de las herramientas jurídicas del paradigma jurídico nacional en función del discurso de los derechos humanos, es decir, la promoción, respeto, protección y garantía de los derechos humanos mediante interpretación conforme al bloque de constitucionalidad y los principios de universalidad, interdependencia, indivisibilidad y progresividad. Todo lo anterior ha provocado ciertos efectos en el sistema jurídico mexicano, entre otros, ha dado origen a la Décima Época de la jurisprudencia del Poder Judicial de la Federación.
DEVRİM ERBİL’İN OSMANLI CAMİLERİ TEMALI ESERLERİNE İKİLİ BAKIŞ
Authors: GÜL Mesut , HAN Yusuf
Published: August 2021

Devrim Erbil’in sanat hayatında 2010-2019 yılları arasında Erken Osmanlı Dönemi ve Klasik Osmanlı Dönemi’ne ait yedi mimari yapı, ikili bakış tekniğiyle uygulandığı 12 resim çalışmaya konu edilmiştir. Osmanlı dönemine ait Selatin camilerinin veya külliyelerinin teknik olarak sanatçının resme yorumlanmasının çözümlenmesi amacıyla mimarlık tarihi, sanat tarihi ve resim alanı açısından incelemeler yapılmıştır. Erbil, ikili bakış yöntemiyle mimari yapılara ait plan veya fotoğrafları üst üste bindirilerek farklı perspektifler oluşturmasıyla özgün resimler oluşturulmuştur. Osmanlı’nın mimarlık açısından şaheserlerinin örtü sistemindeki kubbeleri vurgulaması ve kendi resimlerine taşınması önem arz etmektedir.
Çalışmada Ayasofya ve Osmanlı dönemi eseri olan yapıların konu edildiği resimler ikili bakış açısından çözümlenerek kullanılan plan ve fotoğraflar belirlenmiştir. Görsellerin ayrıştırılmasıyla resimde vurgunun nerelerde kullanıldığı belirlenmiş ve Osmanlı’nın mimaride kimlik öğesi olan kubbelerin ön plana çıkarıldığı tespit edilmiştir. Renk ve tonlamanın örtü sisteminde kullanıldığı ve plan ve fotoğraflardaki perspektif göz önünde bulundurularak tablolara uygulanmıştır. Erbil’in ikili bakış resimlerinde Osmanlı’nın başkentlerinde kubbe mimarisinin gelişim sürecindeki başat yapılar resimlere yorumlanarak işlenmiştir. Erbil, modern sanatın öykünmeci ve deneyimleyici yaklaşımını, ikili bakış tekniğiyle kültürel mirasla bağdaştırmıştır.
Repensar la economía y la sociedad postpandemia: mujeres y vulnerabilidad
Authors: Escobar Bernardita
Published: August 2021

Este ensayo reflexiona específicamente la realidad de la pandemia y la profundización en la vulnerabilidad de las mujeres. Las mujeres representan la mitad de la población del mundo y tal como vamos a discutir, no existe tanta diferencia entre las mujeres que están en Chile, México y Latinoamérica, o en Europa, Estados Unidos y en Asia, es decir, el nivel de vulnerabilidad puede cambiar en algunos países, puede ser mayor que en otros, pero la situación global de afectación hacia la mitad de la población merece la importancia de ser tratado en primer orden.
Presentación del Número Volumen 7 | Número 2 |Julio-Diciembre 2021
Authors: Quezada Mirna Elizabeth
Published: August 2021

En un giro inesperado de acontecimientos para muchos, el año 2021 se ha visto aun golpeado fuertemente por la pandemia de COVID-19 a nivel global. La situación sin duda alguna marca un antes y un después en la historia de la humanidad, ante esto el sistema de salud con sus colosales esfuerzos ha tratado de mantener a flote la sociedad, mientras que ésta se enfrenta a otras consecuencias más allá de la enfermedad. En concreto, México y América Latina por sus características sociales, políticas y geográficas particulares se ha visto fuertemente impactado a nivel salud, pero no solo eso. La sociedad en general ha visto afectaciones no sólo a nivel físico, sino mental y funcional; la interacción ha cambiado, así como el modo de relacionarse y comportarse, por lo que se presentan nuevos problemas sociales o se han agudizado los ya existentes. Por tal motivo, la Revista Digital Internacional de Psicología y Ciencia Social en su segundo número del año 2021, espera reunir las voces de aquellos académicos que construyen conocimiento científico de la serie de secuelas o precuelas de problemáticas sociales diversas derivadas de la pandemia. En este sentido, todos los estratos de la población se han visto afectados, desde niños, adolescentes y adultos, así como sistemas que pensábamos más robustos o estables como la salud, la educación o el contexto laboral; también se ha visto impactada la manera más básica de relacionarse como la interacción social, familiar y ambiental. Por lo que el presente número busca abrir un espacio a aquellos académicos interesados en contribuir desde su trinchera a la comprensión, prevención y tratamiento de dichas problemáticas.
Revista Digital Internacional de Psicología y Ciencia Social | Volumen 7 | Número 2 | Julio - Diciembre 2021
Authors: Becerra Ramírez J. Jesús
Published: August 2021

A pesar de los cambios que ha traído la pandemia para la vida humana, en los que estamos enfocados en los contagios que aumentan día a día, el sistema de salud está prioritariamente centrado en la atención de enfermos por COVID, la educación se da en un formato televisivo y de sincronía por videollamada, la economía trata de estar activa, los sucesos diversos alrededor de la pandemia han estado modificando nuestra cotidianidad, seguimos teniendo problemas que a pesar de la pandemia existen como antes de ésta, los cuales involucran procesos sociales, de tipo organizacional y educativos que atañen a la infancia, los jóvenes y los adultos. Es así como en la investigación de los procesos sociales y psicológicos en la Revista Digital Internacional de Psicología y Ciencia Social, los autores de los manuscritos del presente número exponen sus reflexiones, análisis, propuestas y hallazgos en problemas que no son viejos, más bien que existían antes de la pandemia y siguen presentes durante la misma.
Daya Predasi Ikan Lemon (Labidochromis caeruleus) dan Ikan Kapiat (Barbonymus schwanenfeldii) Terhadap Larva Nyamuk Aedes aegypti
Authors: Andriani Nathania Disa Ariesta , Adrianto Hebert , Darmanto Arief Gunawan
Published: August 2021

Dengue hemorrhagic fever (DHF) is a vector-borne disease that still happens every year in Indonesia. This disease is caused by the dengue virus and transmitted by the Aedes aegypti as its vector. One of the biological vector controls that can be implemented is using fish as a predator of mosquito larvae, such as using Electric Yellow Cichlid fish (Labidochromis caeruleus) and Tinfoil Barb fish (Barbonymus schwanenfeldii). This study aimed to determine the difference in predation capacities of Electric Yellow Cichlid and Tinfoil Barb on Ae. aegypti larvae. This research is quasiexperimental with a completely randomized design (CRD) with Post Test Only research design. One aquarium with three liters of water containing one fish is given 25 Ae. aegypti larvae. Testing of each fish species is carried out in five replications. Fish predation was observed every 30 seconds until all larvae were eaten. The result showed that Electric Yellow Cichlid could prey on 25 larvae in an averagetime of 5.7 minutes, while Tinfoil Barb spent 11.6 minutes. The results of the Friedman test showed that there was a significant time difference in preying time of Electric Yellow Cichlid and Tinfoil Barb. It’s concluded that Electric Yellow Cichlid was more effective as an Ae. aegypti larvae predator.
Spatial Distribution of Malaria Vector Breeding Sites in Purworejo District, Central Java Province
Authors: Sunaryo Sunaryo , Ikawati Bina , Wijayanti Tri
Published: August 2021

Malaria merupakan masalah kesehatan utama di Purworejo terutama pada daerah perbukitan yang berbatasan dengan Kabupaten Magelang, Provinsi Jawa Tengah dan Kabupaten Kulonprogo, Provinsi Daerah Istimewa Yogyakarta. Daerah perbukitan tersebut merupakan daerah reseptif malaria. Keberadaan dari habitat perkembangbiakan vektor malaria yang berdekatan dengan pemukiman serta terjadi setiap musim, menyebabkan penularan malaria terjadi sepanjang tahun. Pemetaan spasial tempat perkembangbiakan vektor malaria dapat membantu penelusuran dan tindak lanjut intervensi terhadap pengendalian vektor malaria. Survei dan pemetaan tempat perkembangbiakan vektor malaria dilakukan menggunakan Global Positioning System (GPS) dan hasilnya diolah dengan ArcGIS. Penelitian dilakukan pada bulan April-November 2018 di Purworejo. Hasil penelitian menunjukkan bahwa tempat perkembangbiakan vektor malaria pada musim kemarau adalah genangan air di sepanjang aliran sungai dan mata air di sekitar pemukiman; dalam bentuk genangan-genangan kecil yang terisi sedikit air. Tempat perkembangbiakan dalam kondisi terlindung dengan adanya tanaman atau pepohonan. Tindakan intervensi yang tepat adalah dengan mengeringkan tempat perkembangbiakan vektor, membuat perlindungan mata air, larvasidasi pada musim kemarau serta penggunaan kelambu berinsektisida pada masyarakat di sekitar tempat perkembangbiakan vektor. Penelitian menyimpulkan bahwa identifikasi tempat perkembangbiakan vektor malaria pada musim kemarau di sepanjang aliran sungai dan mata air.
LAS FORMAS SENSORIALES EN EL CASO MÁS VIDA GUADALAJARA: ANÁLISIS A PARTIR DE BIRGIT MEYER
Authors: Gomes Edson Fernando
Published: August 2021

Este artículo se desprende de la investigación de maestria entitulada Cuando la fe se vuelve marca: la comunicación organizacional y el cristianismo emergente en el caso “Más Vida Guadalajara” que buscó entender y explicar cómo intervienen las estrategias de comunicación en iglesias del cristianismo emergente tal como el caso de Más Vida Guadalajara. La religiosidad que se practica, se reproduce y enseña en esta iglesia utiliza formas sensoriales (Meyer, 2018), como herramientas para captar la atención de los participantes de sus reuniones y así genera una experiencia, y por medio de ella la iglesia transmite un sentido a estos participantes. Este artículo pretende analisar estas formas sensoriales vistas en el caso Más Vida Guadalajara, através de los lentes del trabajo de Birgit Meyer sobre la Estética de la persuasión y las formas sensoriales del cristianismo.
Iniquidades socioeconômicas na saúde bucal de estudantes universitários do sul do Brasil
Authors: Henzel Larissa Tavares , Silveira Mateus Costa , Karam Sarah Arangurem , Schuch Helena Silveira , Cademartori Mariana Gonzalez , Correa Marcos Britto , Demarco Flávio Fernando
Published: August 2021

Objective: To identify the magnitude of the association between dental caries experience and negative self-perception of oral health with socioeconomic determinants. Methods: Cross-sectional study conducted with data from a prospective cohort with university students entering the Federal University of Pelotas (UFPel) in 2016. Data were collected through a self-administered questionnaire, including demographic, socioeconomic and psychosocial characteristics. The outcomes of the present study were experience of self-reported caries (history of caries disease) and self-perceived oral health (positive versus negative). Results: A total of 3,237 students joined, of which 2,089 (64.5%) agreed to participate in the study. The Poisson regression model known that university students with an income of R $ 1001 to 5000.00 and R $ 5001 or more primary, respectively, a prevalence ratio (PR) 14% (PR=0,86; 95%CI 0,80-0,92) and 18% (PR=0,82; 95%IC 0,74 a 0,90) lower of caries experience, as well as individualizing mothers had completed high school prevalence a 14% (PR= 0,86; 95%CI 0,80 a 0,92) lower prevalence and complete higher education 19% (PR= 0,81; 95%CI 0,75 a 0,87) less caries experience when compared to reference groups. In the self-perception of oral health, the results for income of R $ 1001 to 5000.00 and R $ 5001 or more dissipated, respectively, a 23% (PR= 0,77; 95%IC 0,64 a 0,91) and 43% (PR= 0,57; 95%IC 0,45 a 0,72) lower prevalence of having negative self-perception of oral health and qualified originating from complete higher education reported a 23% lower prevalence of negative self-perceived oral health when compared to the reference (PR= 0,79; 95%IC 0,66 a 0,97). Conclusions: The findings of the present study confirm that socioeconomic indicators influence the experience of caries and self-perceived oral health among university students.
De ponta-cabeça: descobrir percepções sensíveis pelos olhos de aspirantes a professores
Authors: Martins Mirian Celeste
Published: August 2021

Os pés no ar, de ponta-cabeça, são um convite à leitura deste texto que se propõe a problematizar os termos aluno, estudante e aspirante à docência e suas conexões com modos de ensinar e aprender; a adentrar na prática da observação de produções infantis; a viver uma pedagogia da escuta sensível, criativa e rizomática ao provocar percepções e análises pautadas em narrativas reflexivas, proposições ampliadoras e ações poéticas. A docência, a criação, a pesquisa e a arte modelam este texto a/r/tográfico na esperança de desvelar a experiência, a prática pedagógica e seus fundamentos e o desafio de aprofundá-los.
Desaprendizagens permanentes: experiências com a arte na Pedagogia
Authors: Egas Olga
Published: August 2021

Este texto apresenta reflexões sobre educação, docência e arte, bem como expectativas sobre o início e término de um percurso possível para a disciplina Fundamentos Teórico Metodológicos em Arte I no curso de Pedagogia, considerando os desafios e as responsabilidades compartilhadas entre professora e estudantes, futuros professores.
Formação docente e literatura de cordel em oficinas didático-investigativas
Authors: Moraes Ana Cristina de
Published: August 2021

O texto reflete sobre formação inicial docente com enfoque numa ação didático-investigativa no curso de Pedagogia envolvendo literatura de cordel no âmbito da realização do componente curricular Arte-educação por meio de aulas-oficinas. Objetiva, com isso, analisar as potencialidades do cordel nesta formação ao mobilizar saberes sobre patrimônio cultural imaterial brasileiro, estrutura de um poema de cordel e produção coletiva deste gênero poético. Com base em autores de referência ao tema e também em observações e análises das discussões e experimentações feitas nas aulas-oficinas, compomos as reflexões presentes nestes escritos.
Carta aos(às) professores(as) de artes e pedagogos(as): diálogos entre Annas, Aninhas e Coras
Authors: Araújo Anna Rita Ferreira de
Published: August 2021

Trabalhar o ensino/aprendizagem da arte nos cursos de Pedagogia se configura como um grande e hercúleo desafio perante a realidade educacional brasileira e as especificidades da formação de pedagogos. Esse artigo/carta é um recorte/relato vivencial da minha experiência à frente da disciplina de Arte e Educação II do Curso de Pedagogia da Faculdade de Educação da Universidade Federal de Goiás no período de 2004 a 2019. Compartilho, entre a escrita epistolar, os poemas de Cora Coralina e os referenciais acadêmicos, a narrativa dos caminhos percorridos junto aos alunos e às alunas que tinha como meta levar à compreensão dos processos de ensino/aprendizagem da arte na educação infantil e nas séries iniciais. Leitura de imagens, desenho infantil, Abordagem Triangular e formação cultural são alguns dos temas presentes. Assim como são abordados aqui algumas metodologias, autores e processos avaliativos que, espero, encontrem encaixes/espaços de diálogos preciosos e reflexivos com os educadores, sujeitos a quem esta carta/artigo se destina.
Dizer sim à existência é o que podemos aprender — pelos caminhos da Arte — com Noemia de Araújo Varela e Nise Magalhães da Silveira
Authors: Azevedo Fernando Antônio Gonçalves de , Araújo Clarissa Martins de , Duarte Ana Maria Tavares
Published: August 2021

Fragmentos da história de amizade entre duas mulheres é o tema deste misto de ensaio e artigo: uma arteducadora, Noemia de Araújo Varela, e a outra, psiquiatra rebelde, Nise Magalhães da Silveira. Ambas estudiosas do caráter terapêutico e pedagógico da Arte. Suas histórias de vida foram marcadas pela incessante busca de construir a escola e o hospital (psiquiátrico) sem muros, ou seja, uma arteducação e uma psiquiatria que diz Sim à existência das diferenças; por isso sofreram tantas hostilidades. Tomamos de empréstimo a expressão “dizer sim à existência” da estudiosa do pensamento foucaultiano Margareth Rago, em seu belo ensaio nomeado “Dizer sim à existência” (2009), obviamente sobre o pensamento do filósofo francês Michel Foucault, pois compreendemos que Noemia Varela e Nise da Silveira viveram suas vidas intensamente, não hesitando frente às adversidades. Para concluir, apresentamos um olhar sobre a exposição Com você meu mundo ficaria completo, de certo modo como uma experiência filiada ao pensamento dessas duas grandes lutadoras por um mundo mais digno para todas as pessoas.
Sardines at a junction: seascape genomics reveals ecological and oceanographic drivers of variation in the NW Mediterranean Sea
Authors: Antoniou Aglaia , Manousaki Tereza , Ramírez Francisco , Cariani Alessia , Cannas Rita , Kasapidis Panagiotis , Magoulas Antonios , Albo-Puigserver Marta , Lloret-Lloret Elena , Bellido Jose , Pennino Maria , Follesa Maria Cristina , Esteban Antonio , Saraux Claire , Sbrana Mario , Spedicato Maria , Coll Marta , Tsigenopoulos Costas
Published: August 2021

By evaluating genetic variation across the entire genome, one can
address existing questions in a novel way while new can be asked. Such
questions include how different local environments influence both
adaptive and neutral genomic variation within and among populations,
providing insights not only into local adaptation of natural
populations, but also into their responses to global change and the
exploitation-induced evolution. Here, under a seascape genomic approach,
ddRAD genomic data were used along with environmental information to
uncover the underlying processes (migration, selection) shaping European
sardines (Sardina pilchardus) of the Western Mediterranean and adjacent
Atlantic waters. This information can be relevant to the (re)definition
of fishery stocks, and their short-term adaptive potential. We found
that studied sardine samples form two clusters, detected using both
neutral and adaptive (outlier) loci suggesting that natural selection
and local adaptation play a key role in driving genetic change among the
Atlantic and the Mediterranean sardines. Temperature and especially the
trend in the number of days with sea surface temperature (SST) above
19oC was crucial at all levels of population structuring with
implications on species’ key biological processes, especially
reproduction. Our findings provide evidence for a dynamic equilibrium
where population structure is maintained by physical and biological
factors under the opposing influences of migration and selection. Given
its dynamic nature, such a system postulates a continuous monitoring
under a seascape genomic approach that can benefit by incorporating a
temporal as well as a more detailed spatial dimension.
Ultrafast layer-by-layer assembly of PDMS for boosting the H2 separation of a P84 membrane
Authors: Li Guozhen , Si Zhihao , Yang Shuai , Xue Tanlong , Baeyens Jan , Qin Peiyong
Published: August 2021

BTDA-TDI/MDI (P84) has been widely applied in gas separation, however,
pinholes or defects on P84 membrane surfaces were formed in the membrane
preparation process and directly weaken its separation performance.
Herein, we developed an ultrafast polydimethylsiloxane (PDMS)
layer-by-layer assembly strategy via spraying method to heal the defects
of the P84 membrane. Firstly, a very short assembly time 20-30 s was
achieved by a UV-curing method. Secondly, both the PDMS spraying
concentration and cycle times were optimized to strengthen the healing
ability of PDMS. The P84-PDMS membrane with 3 wt % PDMS spraying
concentration and 2 spraying cycle times significantly improve the
H2/CH4 selectivity from 62.99 to 231.92 with a satisfactory H2 permeance
(20.85 GPU). The layer-by-layer PDMS assembly strategy for healing
defects of P84 membrane displays outstanding comprehensive abilities,
with an easy manufacturing based upon ultrafast curing and excellent gas
separation performance based on the defect-free membrane structure.
ENGINEERING MACROSEISMIC SURVEY OF EPICENTRAL AREA OF THE EARTHQUAKE ON 14 DECEMBER 2000
Authors: Заалишвили В.Б. , Одишария А.В. , Тимченко И.Э. , Отинашвили М.Г. , Гогмачадзе С.А. , Заалишвили З.В.
Published: August 2021

Приводится анализ землетрясения, произошедшего в 2000 году на территории Грузии. Была прове- дена специальная экспедиция, которую организовал Институт строительной механики и сейсмостойкости АН Грузии. Опрошены жители населенных пунктов, оказавшихся в зоне землетрясения. На основе анализа полученного материала была построена карта изосейст в технологии GIS.

The analysis of earthquake that occurred in 2000 on the territory of Georgia is given. The special expedition was organized by the Institute of Structural Mechanics and Earthquake Engineering of Georgian Academy of Sciences. The residents of the settlements, that were in the earthquake zone were interviewed. Based on analysis of the material obtained was built isoseists map using GIS technologies.
SEISMIC RISK ASSESSMENT OF URBANIZED TERRITORY
Authors: Заалишвили В.Б. , Дзеранов Б.В. , Невский Л.Н. , Архиреева И.Г.
Published: August 2021

На основе учета всей совокупности факторов сейсмическая опасность, уязвимость застройки, сейсмический риск, разработана методика оценки и прогноза сейсмического риска. Используя полученные результаты, выполнена оценка сейсмического риска территории города Владикавказа, что позволило выделить наиболее сейсмически уязвимые участки

Based on accounting all factors: seismic hazard, vulnerability of buildings a method of seismic risk assessment and prognosis of seismic risk is developed. Using the developed methodology the seismic risk assessment of Vladikavkaz city is performed, this allowed to identify the most seismically vulnerable areas
SEISMOLOGICAL OBSERVATIONS ON THE TERRITORY OF THE REPUBLIC NORTH OSSETIA-ALANIA
Authors: Заалишвили В.Б. , Невская Н.И.
Published: August 2021

Рассмотрено развитие сейсмологических наблюдений на территории Республики Северная Осетия-Алания. Создание локальных сетей сейсмических наблюдений является составной частью комплексных геофизических наблюдений в регионе и позволяет разработать геолого-геофизических аспекты устойчивого развития горных территорий, исследовать напряженно-деформированное состояние горного массива при технологическом вмешательств и, наконец, исследовать опасные эндогенные и экзогенные процессы и сопутствующие им опасные геологические явления.

The article considers the development of seismological observations on the territory of the Republic of North Ossetia-Alania. Creation of local seismic observation networks is a component part of complex geophysical observations in the region and it allows developing geologic-geophysical aspects of sustainable development of mountain territories it also allows investigating strain-stress massif condition under anthropogenic impact and, finally, it allows investigating hazardous endogenous and exogenous processes and accompanied geological phenomena.
SPECIFICATION OF INTEGRATED ESTIMATES OF SUSCEPTIBILITY OF GEOSYSTEMS TO NATURAL DANGEROUS PROCESSES: PROBLEMS OF REALIZATION, INTERPRETATIONAL ANALYSIS
Authors: Марченко П.Е.
Published: August 2021

В соответствии с авторской методологией численной интегральной оценки степени подверженности геосистем опасным природным процессам, опирающейся на геоинформационные модели и методы, по- лучены и представлены в картографической форме интегральные оценки фактической природной опас- ности геосистем Кабардино-Балкарской Республики, отличающиеся степенью детализации при измене- нии размеров анализируемых геотаксонов.

According to authors methodology of a numerical integrated assessment of degree of the susceptibility of geosystems to natural hazards basing on geoinformation models and methods, the integrated estimates of the actual natural danger of geosystems of Kabardin-Balkar Republic, differing in extent of specification at change of the sizes of the analyzed geotaxons, are received and presented in a cartographical form.
METALLOGENY OF THE NORTH CAUCASUS – PRESENT AND FUTURE
Authors: Черкашин В.И. , Богуш И.А.
Published: August 2021

В работе рассматриваются новые представления о металлогении юрских комплексов Северного Кав- каза. Обращается внимание на широкое площадное развитие стратиформного оруденения полиметаллов, свинца, цинка, золота, меди, связанных с раннеальпийскими (киммерийскими) тектоническими движени- ями. Приводятся примеры двух типов регионального стратиформного свинцово-цинкового и колчеданно- го оруденения

In this paper we consider new ideas about the Jurassic metallogenic systems of the North Caucasus. Attention is drawn to the wide-areal development of stratiform mineralization of base metals, lead, zinc, gold, copper, associated with the early Alpine (Cimmerian) history of geological development is paid. The examples of two types of regional stratiform lead-zinc and pyrite mineralization are given.
STATE OF ATMOSPHERIC POLLUTION AND MORBIDITY OF THE POPULATION OF VLADIKAVKAZ CITY
Authors: Бериев О.Г. , Заалишвили В.Б.
Published: August 2021

В статье исследовано состояние загрязнения атмосферы и заболеваемости населения на территории г. Владикавказа за пятилетний период. Установлена тенденция к снижению выбросов в окружающую сре- ду главным образом за счет уменьшения объемов производств и выполнения природоохранных меропри- ятий на промышленных предприятиях города. Вместе с тем, отмечается рост количества автотранспорта и его техногенная нагрузка на среду неуклонно увеличивается.

State of air pollution and the incidence of population on the territory of Vladikavkaz city for the five-year period are investigated in the paper. The tendency of reduction of emissions into the environment (mainly due to the reduction of production volume and implementation of environmental activities at the industrial enterprises of the city) is stated. At the same time, number of vehicles and corresponding anthropogenic impact on the environment are steadily increasing
PECULIARITIES OF FORMATION OF CHEMICAL COMPOSITION OF THE EASTERN DONBAS MINE WATERS FOR A CENTENARY PERIOD
Authors: Гавришин А.И.
Published: August 2021

Закономерности формирования химического состава шахтных вод в Восточном Донбассе изучены за столетний период с 20х годов XX века по 2010 год. Всего использовано более 1500 анализов. Наиболь- шие изменения химического состава отмечены в 40е и 50е годы, и после массовой ликвидации угольных шахт в регионе в 90е годы. Вынос растворённых веществ шахтными водами на поверхность достиг мак- симума к 2010 году, что вызвало интенсивное загрязнение природных вод. Выделено четыре главных на- правления трансформации химического состава шахтных вод в регионе, дана интерпретация их генезиса.

Regularities of formation of chemical composition of mine waters in the Eastern Donbas are studied in the space of the centenary since twenties of 20 century until the year 2010. In all, more than 1500 analyses have been used. The largest changes of chemical composition are recorded in 40th and 50th years, and after mass liquidation of coal mines in the region. The carrying away of dissolved substances reached its maximum in the year 2010, what caused an intensive pollution of natural waters. The four main directions of transformation of mine waters chemical composition have been singled out in the region and interpretation of their genesis given.
MONITORING AND FORECASTING OF THE LANDSLIDE PROCESSES IN GROZNY
Authors: Дмитриева Е.В. , Сергеев С.И. , Сергеев И.А. , Стефанов А.А. , Тихонов А.И.
Published: August 2021

В данной статье рассматривается применение кинотеодолитного метода для наблюдения за динами- кой смещений оползневого склона. В сочетании с метеорологическим и геофизическим мониторингом кинотеодолитный метод позволяет заблаговременно распознать переход оползня в активное состояние и в итоге провести мероприятия по защите населения до начала фазы катастрофических смещений

The article considers the usage of cinetheodolite method for displacement dynamics of the landslide slope observation. In combination with meteorological and geophysical monitoring cinetheodolite method allows identifying in advance the change of landslide into the active state and as the result carrying out the measures on population safety before the phase of catastrophic displacement
ANALYSIS OF OBSERVATIONS OF NATURAL PULSED ELECTROMAGNETIC FIELD OF THE EARTH USING STATIONS NETWO RK OF NORTH CAUCASUS REGION. ISOLATION OF CHARACTERISTIC ANOMALY FORMS, THAT ARE PRECEDING SEISMICITY ACTIVATION OF THE CENTRAL AND EASTERN CAUCASUS
Authors: Забирченко Д.Н. , Дьяконов С.С.
Published: August 2021

В результате анализа многолетних рядов наблюдений за естественным импульсным электромагнитным полем Земли (ЕИЭМПЗ) по сети из 10 регистраторов, расположенных от Черного до Каспийского моря в пределах сейсмоопасных районов Северо-Кавказского региона, выделены характерные образы аномалий, предваряющих сейсмические события с магнитудой более 4. Сделана попытка проанализировать взаимосвязь аномалий ЕИЭМПЗ с активизацией сейсмичности наиболее горячих сейсмических областей Центрального и Восточного Кавказа.

An analysis of long-term series of observations of the natural pulsed electromagnetic field of the Earth in a network of 10 registrars, located on the Black Sea to the Caspian Sea within the seismic areas of the North Caucasus region, marked characteristic regional features of the behavior of diurnal and seasonal variations of geophysical fields. Developed a method for detecting anomalies with the offset intensity seasonal background. Do an attempt to analyze the relationship anomalies with the activation of the hot seismic regions in Central and Eastern Caucasus