bluuebunny/crossref_metadata_2025 huggingface dataset:
Development, characterization in vitro and in silico of coenzyme Q10 loaded myristic acid with different liquid lipids nanostructured lipid carriers
Authors: Aryani Ni Luh Dewi , Siswandono Siswandono , Soeratri Wdji , Putri Dian Yulyandani , Puspitasarini Pingky Dwi
Published: September 2022

Context: Nanostructured lipid carriers can enhance skin penetration of active substances. Coenzyme Q10 is a lipophilic antioxidant, that has poor skin penetration. This limitation is overcome by nanostructured lipid carriers. Aims: To developed coenzyme Q10 nanostructured lipid carriers using myristic acid with various liquid lipids as lipid matrix by in vitro studies and in silico approach for explaining the interaction of coenzyme Q10-lipid at the molecular level. Methods: The coenzyme Q10 nanostructured lipid carriers were prepared using myristic acid as solid lipid with oleic acid, isopropyl myristate, and isopropyl palmitate as liquid lipids using the high shear homogenization method. Then, they were evaluated in physicochemical characteristics by dynamic light scattering, differential scanning calorimetry, Fourier transforms infrared, scanning electron microscopy, spectrophotometry ultraviolet-visible, and pH meter. Furthermore, the in silico studies were conducted using AutoDock 4.2. Results: The coenzyme Q10 nanostructured lipid carriers using myristic acid-oleic acid, myristic acid-isopropyl myristate, and myristic acid-isopropyl palmitate as lipid matrix had the mean particle size, polydispersity index, entrapment efficiency, drug loading, and pH value were less than 300 nm, less than 0.3, more than 80%, about 10%, and about 5.0, respectively. Moreover, molecular docking of coenzyme Q10 and lipid showed hydrogen and hydrophobic bonds. These results supported differential scanning calorimetry and Fourier transforms infrared results. Conclusions: The coenzyme Q10 nanostructured lipid carriers were successfully prepared using myristic acid-oleic acid, myristic acid-isopropyl myristate, and myristic acid-isopropyl palmitate as lipid matrix as well as in silico study could be used for explaining of coenzyme Q10-lipid interaction.
El derecho a la alimentación con enfoque diferencial
Authors: Rojas Nastassja , Quintero Germán , González Claudia , Angel Sergio , Muñoz Lina , Cárdenas Caroll , Bohórquez Valentina , Herrera Maria Camila , Suárez Alejandra , Serna Daniela
Published: September 2022

El presente informe se presenta como un recorrido sobre la importancia de considerar el enfoque diferencial en cuanto a la protección de los Derechos Humanos, siendo es una medida que permite, tanto a las instituciones como a la sociedad civil, dejar de presente las causas por las cuales un grupo poblacional tiene dificultades en el goce efectivo de sus derechos, y así, poder tomar acciones adicionales para la gestión adecuada de estas diferencias que pueden estar generando algún tipo de discriminación o desventaja. Dentro de estas diferencias se reconocen enfoques diferenciados sobre edad, género, sexo, etnia, raza, discapacidad, entre otros.
Informe No.1 Estándares internacionales: Derecho a la Alimentación
Authors: Rojas Nastassja , Daniela Daniela , Muñoz Lina , González Claudia , Quintero Germán , Angel Sergio , Bohórquez Valentina , Cárdenas Caroll , Herrera Maria Camila , Suárez Alejandra
Published: September 2022

En este primer informe se presenta como paso necesario para el abordaje de esta problemática, los estándares internacionales en materia de derecho a alimentación en los sistemas de protección de Derechos Humanos, tanto a nivel universal como interamericano. Realizado un trabajo de investigación y sistematización de los estándares encontrados se presentan aquellos lineamientos fundamentales a tener en cuento cuando del Derecho a la Alimentación se trata.
Innovative FE Analysis to Investigate the Effect of Flexural Reinforcement on the Behavior of Beams
Authors: A. Gouda Sayed Ahmed , H. Ali Ahmed , M. Mohamed Hamdy
Published: September 2022

Legal challenges to child education create barriers to assisting abused children and their families. The purpose of this study was to describe legal challenges to child education. A qualitative study was conducted to explore the legal challenges. Individual interviews with about 20 people. Grounded theory methodology was used to develop categorical themes that reflected experiences and challenges. Three themes emerged from the data: legal challenges create complex dilemmas for education rights. Also, it has a common denominator with the legislative decree. The Islamic Shariah has taken great care of human life, particularly children. The Shariah system has introduced many legislations that preserve children’s rights, including their right to education, reform and education. Thus, this study is faced with a considerable amount of primary legislation in the child’s life to preserve it and its development, and from this I chose to address it (the rights of the child in education and education in the legal and legal perspective. It focused on the essential legislative dimensions that preserve children’s rights to education and read the following international law
Accounting Presentation and Disclosure in the CAs: A Review
Authors: M. Albaz Maged , A. Alhijris Ali , Z. Metwaly Ahmed
Published: September 2022

The CAs tend to follow social accounting requirements that are based on “Logical and systematic analysis of the organization activities impact on the society and other stakeholders and to show this effect information in the financial statements”. Due to the social nature of the CA‟s activities. In this sense the accounting recognition is the start point of the comprehensive accounting function. While the accounting measurement is one of the influencing elements of the accounting function, and its importance increased by moving towards the accounting compatibility for this sector organizations. Moreover, the accounting presentation and disclosure issue are the most controversially debate in the NPS. Furthermore, Academic studies tended to assert that the accounting in the contemporary concept must serve the organizations and society at the same time, regardless of Organization‟s objective, and Based on the concept of accountability and especially the social accountability. Therefore, the organizations must be in an accountable position, Not only for the owners or shareholders (traditional concept), but to the society for its overall operations and activities. Keywords: Accounting Presentation/ Disclosure/ CAs/ NPOs
Review the Legal Perspective of The Child’s Education Rights Based on the International Law
Authors: Rzaij Aswad Abed , Mohamed Abdeldayem Amr , Khalifa Mahmoud
Published: September 2022

Legal challenges to child education create barriers to assisting abused children and their families. The purpose of this study was to describe legal challenges to child education. A qualitative study was conducted to explore the legal challenges. Individual interviews with about 20 people. Grounded theory methodology was used to develop categorical themes that reflected experiences and challenges. Three themes emerged from the data: legal challenges create complex dilemmas for education rights. Also, it has a common denominator with the legislative decree. The Islamic Shariah has taken great care of human life, particularly children. The Shariah system has introduced many legislations that preserve children’s rights, including their right to education, reform and education. Thus, this study is faced with a considerable amount of primary legislation in the child’s life to preserve it and its development, and from this I chose to address it (the rights of the child in education and education in the legal and legal perspective. It focused on the essential legislative dimensions that preserve children’s rights to education and read the following international law
STRATEGI DAN TANTANGAN PENGUMPULAN DANA HASIL KOIN NU PADA UPZIS NU KECAMATAN BATANGHARI LAMPUNG TIMUR
Authors: Ansori Yahya  , Khoirul Abror  , Erike Anggraeni
Published: September 2022

The Zakat Infaq and Shodaqoh Nahdlatul Ulama Management Unit (UPZIS NU) of Kecamatan Batanghari has formed several NU UPZIS at the village or sub-district level. The program currently being carried out by the Infaq Zakat Management Unit and Shodaqoh Nahdlatul Ulama at the village level is the "Nahdlatul Ulama Infaq Box Movement" (KOIN NU). However, in its implementation there are several obstacles experienced by several UPZIS NU at the village level in Kecamatan Batanghari. Some of these obstacles include the distribution of Infaq Boxes to the community that has not been maximized, there are still pros and cons and even rejection in the community regarding the implementation of activities. The purpose of this study was to find out what caused the NU KOIN Program to not be maximized as well as the pros and cons and even rejection in the community about the implementation of activities in several villages in Kecamatan Batanghari. This research was conducted using a qualitative descriptive method, namely research that utilized qualitative data and then described it descriptively. Data collection in this study was carried out using primary data and secondary data. The result of this research is that the response of the people of Batanghari Sub-district to the KOIN NU program is very good. However, due to the lack of socialization, the vastness of the area and the absence of a special team tasked with socializing activities in the community, the implementation of activities in the community has not been maximized and there are still pros and cons and even rejection in the community. The solutions offered by researchers related to this problem are First, UPZIS NU Management at all levels must be more aggressive in conducting socialization in the community, including forming a special team to conduct socialization directly or through social media; Second, the results of the infaq box must be immediately distributed to the community; Third, always coordinate with religious leaders and community leaders; Fourth, submit reports related to the management of KOIN NU results to the community for the sake of transparency.
ANALISIS PEMBIAYAAN MUDHARABAH PADA PT. BANK SUMUT KCP SYARIAH STABAT ( Tinjauan Fiqih Muamalah)
Authors: Ayu Liviana  , Anjur Perkasa Alam  , Azhar
Published: September 2022

The purpose of this study was to determine the process of financing the mudharabah contract at PT. Bank Sumut Kcp Syariah Stabat. To find out the review of Fiqh Muamalah on the process of financing the mudharabah contract at PT. Bank Sumut Kcp Syariah Stabat. To find out the products that exist at Bank Sumut Kcp Syariah Stabat which sell mudharabah contracts. This type of qualitative research is used in this study using descriptive analysis methods. Descriptive analysis is used to explore the collected data and describe clearly the problems and research results. Data collection is done through observation, interviews or structured interviews, and documentation. The results of this study indicate that financing in general is the provision of money or an equivalent claim, based on an agreement or agreement between the bank and another party that requires the party being financed to return the money or bill after a certain period of time with a reward or profit sharing. The principle of mudaraba, the depositor acts as shahibul maal (owner of capital) and the bank as mudharib (manager). The funds are used by the bank to finance murabahah or ijarah as previously described. The bank can also use the funds to carry out mudharabah financing. The results of this business will be divided according to the agreed ratio. In the event that the bank uses it to carry out mudharabah financing, the bank is fully responsible for the losses that occur. The pillars of mudharabah are perfectly fulfilled (there are mudharib, there are owners of funds, there is a business that will be shared, there is a ratio, there is consent and acceptance). This mudharabah principle is applied to time deposit and time deposit products.
PERSEPSI TOKOH MASYARAKAT KOTA TANJUNG PURA TENTANG ISU RIBA DALAM MENINGKATKAN MINAT MASYARAKAT MENABUNG DI BANK SYARIAH INDONESIA KCP STABAT
Authors: Fariz Arkhan  , Diyan Yusri  , Anjur Perkasa Alam
Published: September 2022

Sharia Bank is a financial institution tasked with collecting funds and distributing funds as well as providing other services based on the principles of partnership, fairness, transparency and universality as well as conducting banking business activities based on sharia principles. The development of Islamic banks is currently quite fast, but lately Islamic bank customers have different perceptions of Islamic banking, where some people hear about news or issues circulating about the perception of public figures who say that Islamic banks still use the principle of usury. which is a benchmark for some people and raises its own doubts about saving in Islamic banks, this is caused by several factors. First, the lack of socialization carried out by Islamic banks. Second, the lack of understanding of public figures regarding the system and objectives of Islamic banking itself.

The formulation of the problem in this research is how is the perception of community leaders in increasing people's interest in saving?

This type of research is a field research (field research), and is descriptive qualitative. The results of this study state that the perception of public figures in increasing public interest in saving in Islamic banks is in the Good category. Good category, customers already understand what Islamic banking is like, customers already know Islamic banks and not a few customers who already understand Islamic banking, and the public confirms that there are issues circulating in the community where public figures still have the assumption that Islamic banks are no different from conventional banks, while the issue of usury on people's interest in saving Islamic banks is in the medium category, meaning that the issue of usury circulating among the public has quite an impact on people's perceptions, therapy does not have much impact on people's interest in saving.
ANALISIS PENDAPATAN DESA TERHADAP ALOKASI BELANJA DESA PADA DESA MUARA KILIS KECAMATAN TENGAH ILIR KABUPATEN TEBO
Authors: Irwansyah Abdulrahim , Novi Mubyarto  , Khairiyani
Published: September 2022

This research is entitled Analysis of Village Income Against Village Expenditure Allocation in Muara Kilis Village, Tengah Ilir District, Tebo Regency. This research aims (1). To explain village income and village expenditure in Muara Kilis village in 2020. (2). To explain the Village Expenditure Allocation based on the realization of Village Income in Muara Kilis Village in 2020. The results of this study are: (1) Muara Kilis Village Revenue realized in 2020 consists of 1) State Revenue and Expenditure Budget Allocation (Village Fund) of Rp. 980,390,000. 2) Share of Regional Taxes and Regional Levies for Regency/City, amounting to Rp. 18,245,614. 3) Village Fund Allocation of Rp. 622,447,000. 4) Financial Assistance from the Provincial APBD and Regency/City APBD of Rp. 60,000,000. With a total village income of Rp. 1,681,082,614. Meanwhile, Muara Kilis Village expenditure in 2020 is allocated to five sectors, namely, 1) Village Government Implementation of Rp. 621,492,614, 2) Village Development of Rp. 293.957.300, 3) Village Community Empowerment of Rp. 59,950,700, 4) Community Development of Rp. 39,200,000, and 5) Disaster Management and Emergency Expenditure of Rp. 666,482,000. With a total village income of Rp. 1,681,082,614. (2) In Muara Kilis Village, with a total income of Rp. 1,681,082,614 has not been able to realize income from 3 other sources of income, namely from Village Original Income, Grants from third parties, and other legitimate income. As can be seen in the data above, which shows that the income from the three sources is 0% or Rp. 0 rupees. Meanwhile, Muara Kilis Village Expenditures are by Government Regulation Number 47 of 2015, which must be used with the following provisions: At least 70% (70% or more) of the village's total spending budget will be used to fund the village administration. Implementation of village development, village community development, and strengthening of rural communities (4 regions). Up to 30% (≤30%) of the village's total budget will be used for the four items. 1) bonds and allowances for village mayors and village officials, 2) village government obligations, 3) allowances and obligations, village advisory boards, and 4) incentives for Rukun's neighbors.
Cholinesterase Inhibitory Activities and In Silico Docking Studies of Blumeatin Isolated from Blumea balsamifera L. DC.
Authors: Acero Rosemarie Elloisa , Amor Evangeline
Published: September 2022

Cholinesterase inhibition provides symptomatic treatment for neurodegenerative diseases such as Alzheimer’s disease. Commercially available drugs on the market mostly target acetylcholinesterase. However, evidence suggests that selective inhibition of butyrylcholinesterase may lead to greater efficacy with fewer side effects and slower disease progression. The aim of this research was to isolate a butyrylcholinesterase-selective inhibitor from Blumea balsamifera L. DC. In vitro cholinesterase assays were used to evaluate the inhibitory activity and mechanism of action of blumeatin. Molecular docking studies were performed to support the BuChE- selectivity of blumeatin. Blumeatin inhibited BuChE in a concentration-dependent manner, with an IC50 of 136.3 ± 12.6 μM and a selectivity ratio of 1.395 for BuChE over AChE. Additionally, the Ki of blumeatin is 10 times lower in BuChE compared to AChE. Molecular docking studies confirmed the selectivity, as revealed by the tighter hydrogen bonding of blumeatin with the BuChE’s active site. Blumeatin acts as a competitive inhibitor and a noncompetitive inhibitor of BuChE and AChE, respectively. With these results, blumeatin could be a potential lead as a drug treatment for AD because of its butyrylcholinesterase selectivity.
Low pH and Low Coral Cover at a Shallow Hydrothermal Vent Site in Batangas, Philippines
Authors: Reyes Michelle , San Diego-McGlone Maria Lourdes , Pavia Richard , Opiña John , Isah Raffi , Magyaya Ryan , Morris John , Tamayo Natasha , Licuanan Wilfredo
Published: September 2022

The coral community and pH conditions were characterized at a shallow hydrothermal vent in Batangas, Philippines. Hard coral cover was 14.8 ± 12.5% (mean ± standard deviation) and made up of more than 26 hard coral TAUs (taxonomic amalgamation units). Seawater pH was highly dynamic, especially near the most active vent plume, ranging from a low of 6.12 to a high of 8.09 over the 10 m x 10 m site. Fourteen (14) coral TAUs were found within 1 m of this vent plume, suggesting they can persist under variable pH conditions. These results contribute towards understanding the response of coral communities under future climate change scenarios.
Ice Sensing Technologies with Applications in Augmented Situational Awareness
Authors: Garvin Matthew
Published: September 2022

This paper contains a literature review of technologies employed in the scientific literature to provide data on ice severity to augment situational awareness of human operators (aboard a ship or in a remote control center) and eventually autonomous navigation algorithms. As ships navigate in ice, masters use a wide source of information to assess the ice conditions along their planned route. This information is used to make ongoing assessments of the ice severity and to decide how to optimize the route to avoid damage to the ship, besetting, etc. Typically, this assessment is made by the officers in charge of the ship based on observations, experience, and metocean publications such as weather forecasts and ice charts. Significant levels of experience needed to safely assess and navigate in complex or severe ice conditions. A fundamental challenge in allowing autonomy or decision-support for navigation of ice-covered waters is providing accurate and relevant ice severity data that feeds decision-making.
Die Theorie des Erscheinens
Authors: Hübner Johannes
Published: September 2022

Abstract. According to the theory of appearing, veridical perception consists in an irreducible relation of appearing between a perceiving subject and a physical object. The paper sketches the development of the theory and its relation to competing views (sense data theory, adverbialism, representationalism). The most worked-out version of the theory, due to William Alston, is found lacking on several counts. First, Alston’s account of the phenomenal character of perception succeeds only if we disregard the possibility of illusion. Second, the account implies, implausibly, that to be deceived by hallucination is to commit an introspective error concerning the phenomenal character of one’s own experience. Another unintuitive implication of the theory is that veridical perception involves not one but two objects appearing to the subject: the physical object perceived and a further, special object required to account for the possibility of hallucinatory experience. Finally, relative to its competitors, the theory of appearing is not in a privileged position to explain how perception can be a source of justification for empirical judgements.
Aufklärung als Ethos – Ein kleiner Beitrag des Mittelalters zur Frage: Was ist Aufklärung?
Authors: Schick Stefan
Published: September 2022

Abstract. Both in academic and public discussions the term “enlightened” is not only an often used but also an often misused one. Thus, this article again investigates the question “What is Enlightenment?” One main thesis, which for some contemporary self-proclaimed followers of Enlightenment may be a bit hard to swallow, is that it is just the influence of a certain mediaeval thinker on historical Enlightenment that can help to develop a systematic and not only historical concept of Enlightenment. For this purpose, this article combines three problems of this very concept: the discussion on “What is Enlightenment?” in late German Enlightenment; the fuzziness of any distinction between “Enlightenment” and “Counter-Enlightenment”; the very difference between the way that Jewish Enlightenment (Haskala) and “Christian” Enlightenment refer to their mediaeval philosophical ancestors.
La cura di molti. Machiavellis Begriff des Politischen und sein politisches Denken
Authors: Grosser Florian
Published: September 2022

Abstract. This article examines Niccolò Machiavelli’s central political writings by means of asking whether his thinking is structured by an underlying concept of the political. In exploring the ways in which Machiavelli (a) addresses some of the basic conditions that determine the political realm and (b) reflects upon the conditions for practical success in this domain, the contours of an implicit, yet consistent concept of the political become apparent. It will be argued that, with regard to its content, this concept is irreducible to the aspect of power. Instead, it is an element of care – or more specifically: ‘care of many’ – that is characteristic of Machiavelli’s understanding of the political and that decisively informs his considerations on both principalities and republics.
Utopie und Negativität. Adornos negative Dialektik als Paradigma utopischen Denkens
Authors: Sommer Marc Nicolas
Published: September 2022

Abstract. This article looks at Adorno’s negative dialectics by focusing on the concepts of negativity and utopia. Against later Critical Theory and social theories similarly oriented towards emancipation, which tend to discredit the concept of utopia in favor of an orientation towards pragmatic goals, I want to show that Adorno’s negative dialectics formulates a position that surpasses the antithesis of realism and utopia by presenting us with pragmatic goals while still retaining a strong concept of utopia.
Bolzano über Willensfreiheit
Authors: Krause Andrej
Published: September 2022

Abstract. In his Athanasia, the main source of his metaphysics, Bolzano deals with the problem of the freedom of the human will. This paper reconstructs two definitions of free will and focuses on Bolzano’s arguments and counter-arguments for and against the existence of free will. These arguments are confronted with some aspects of the modern discussion of this subject. The paper examines especially how far the so called principle of alternate possibilities is relevant for a better understanding of Bolzano’s arguments. Assuming the reconstructed definitions of the freedom of the will, it turns out that a person has only free will if this person could have wanted otherwise. But, according to Bolzano’s view in the Athanasia, the possibility to want otherwise is not a necessary condition for moral responsibility. Finally, the paper shortly discusses whether, for Bolzano, people are free after death and whether God is free.
Geschichte am Scheideweg. Heidegger und der Surrealismus bei Benjamin
Authors: Ferencz-Flatz Christian
Published: September 2022

Abstract. The following paper is grounded on a reflection found in Walter Benjamin’s Arcades Project, opposing Martin Heidegger’s conception of historicity to the one put forth in the writings of the surrealists. By interpreting Benjamin’s own view of the surrealists’ approach to history and its core motifs, on the one hand, and his interpretation of Heidegger as sketched out in several other brief passages, on the other hand, we wish to show that Benjamin did not share the facile view on Heidegger’s conception of history held by Adorno, Habermas or Marcuse, but instead his critique proves a very nuanced reading of Heidegger, allowing us to outline the fundamental opposition between an existential and a political approach to the philosophy of history.
Die Frage nach dem Individuationsprinzip. Eine vergleichende Analyse der Diskussionslage in der analytischen Ontologie und bei Duns Scotus
Authors: Chabada Michal
Published: September 2022

Abstract. The question of the principle of individuation in current analytical philosophy was the subject of medieval discussions, too, in which not only similar proposals of solutions emerged, but also dilemmas invoked by the set of then-discussed proposals appeared. Duns Scotus criticizes the previous theories of individuation and suggests that the difficulties could be avoided by changing the viewpoint from the categorical-quiditative to the transcendental-modal understanding of the principle of individuation. Scotus’ solution is close to the theory of naked substrates, because the substrate and “thisness” act as individuators with modal character. From the relecture of Scotus’ modal understanding of the principle of individuation may arise inspirations that need to be considered in comparison with modern analytical theories of individuation and thus they can be enriched.
Der tragische Grund der Philosophie. Das Tragische als diachrone und synchrone Bedingung philosophischen Denkens
Authors: Rasche Michael
Published: September 2022

Abstract. Tragedy and philosophy are two distinct forms of interpretation of the world, both developed at the same time in Greece: both are two aspects of a certain mindset of that historical period. The philosophy is systematically and historically successive to tragedy. The tragedy, however, is not only preceding the philosophy, but also accompanying its origin and even forming the contentual cause of philosophy. To illuminate this cause, it is necessary to understand the tragedy and the philosophy as a common distinction from that which precedes them and that they both seek to overcome: the myth. The reciprocal relationship of tragedy and philosophy can be described in the context of their common critique of the myth. At the same time, the phenomenon of tragedy is to be understood as a condition of philosophy, insofar the tragic is an expression of a mindset that allows philosophical thought.
Der Intellekt ist nicht genug. Das proklische „unum in nobis“ bei Berthold von Moosburg
Authors: OP Paul D. Hellmeier
Published: September 2022

Abstract. In his commentary on the Elementatio theologica of Proclus, Berthold von Moosburg claims that the Proclean supersapientia is superior to Aristotelian metaphysics because it has a cognitive principle that is superior to the intellect. This unum in nobis also establishes a cognitive habitus, which consists in the union with the divine. This article shows how Proclean science leads to deification and to what extent it is the expression and conscious realization of deification. Examining the relationship between the “one in us” and the intellect, it becomes clear that Berthold does not equate them with each other. Nevertheless, the intellectus adeptus, in whose conception Berthold is more oriented to Albertus Magnus than to Dietrich von Freiberg, is a necessary and never fully obsolete precursor for the union with the divine. With this view, Berthold integrates the Arabic-Peripatetic doctrine of the acquired intellect into the Proclean doctrine of the five modes of knowledge, thus returning them to their historical and systematic origin.
Personality Merchandising and the GDPR: An Insoluble Conflict?
Authors: Sun Jingzhou
Published: September 2022

Upon almost identical conditions of application, the GDPR takes precedence over national legal regime for merchandising. It raises the research question: how would the GDPR regulate merchandising? And, whether the consequences are theoretically justified and practically reasonable? Unlike the GDPR, which is devised to enhance one’s control over personal data by omitting its commercial value and limiting personal autonomy in private law, the German legal regime recognizes the pecuniary components in the right to one’s image and de facto confirms their licensability. The KUG offers over 100 years of experience in merchandising for the GDPR’s risk-based approach.
Flores matinais colhidas ao entardecer - 朝花夕拾
Authors: Xun Lu
Published: September 2022

Este livro inaugura a Série Clássicos da Literatura Chinesa, fruto de uma parceria da Editora com o Instituto Confúcio da Unicamp. A obra reúne dez textos em prosa escritos em 1926. Conhecida como coletânea de textos reminiscentes, traz registros de memória que ilustram os caminhos trilhados e as experiências adquiridas pelo autor, da infância até a juventude. São, ao mesmo tempo, retratos vívidos do cotidiano do final da dinastia Qing até o início da República na China. Clássico da prosa moderna chinesa, o livro conta ainda com prefácio e posfácio do próprio autor, além de uma apresentação e um texto introdutório, que situam o autor e a obra.
Survival of Acute Myeloid Leukaemia Patients- A Retrospective Study from the Yopougon University Hospital, Abidjan, Ivory Coast
Authors: Silue Alexis Dohoma , Ndhatz Emeuraude , Ayemou Romeo , Kouakou Boidy , Nanho Clotaire Danho , Kamar A Ismael , Meite Ndogomo , Koffi Gustave Kouassi
Published: September 2022

Introduction: The survival of acute leukaemia patients has improved significantly thanks to multidrug chemotherapy and the development of cell therapy and marrow transplantation. However, this is not the case in Middle Income Countries (MICs), particularly in Côte d’Ivoire, West Africa where much efforts are still needed to improve the treatment of these patients.This study raises the issue of the fate and survival of Acute Myeloid Leukaemia (AML) patients in these countries. Aim: To study the overall survival and survival factors of patients with AML under the present practice conditions. Materials and Methods: This retrospective study was conducted in the Department of Haematology of Yopougon University Hospital in Abidjan, Ivory Coast. The data was collected from January 2005-April 2019 and data processing happened over a duration of one year from November 2019-November 2020. The mortality and survival were studied on 75 AML patients.The socio-demographic, pretherapeutic and therapeutic characteristics were recorded. Statistical Package for the Social Sciences (SPSS) statistics version 26 was used for data analysis, comparisons were done using by the Chi-square test and survival through the Kaplan Meier method and the log rank test. Results: The patient’s age ranged from 1 to 74 years, with two peaks (37 and 49 years old) with a sex ratio at 1.03. Majority of patients (50.7%) had a low socio-economic level. Overall, 81.6% of patients started treatment within two weeks. Out of total patients 38 (50.7%) patients received chemotherapy, which was curative for 10 (13.33%) patients and palliative for 28 (37.33%) patients. There was not a single patient of complete remission. A total of 4 (5.3%) were alive, 51 (68%) died, and 10 (26.7%) were lost to follow-up. The average overall survival (OS) was 90 days and the probabilitý of Overall Survival (OS) was 62% at one month, 49% at six months, and 10% at one year. The predictive factors for prolonged survival were high socioeconomic level (p=0.046) - absence of bleeding syndrome (p-0.04) - haemoglobin level ≥10 g/dL (p-0.02) - cytological type different from AML-M0 (p-0.05). Conclusion: The therapeutic results were inferior to those obtained in developed countries where high level diagnostic and therapeutic techniques give very promising results. This study highlighted the difficulties of AML management and identified five prognostic factors of survival in the care conditions of MIC.
Histomorphological Spectrum and Immunohistochemical Features of Gastrointestinal Stromal Tumour: A Series of Eight Cases
Authors: Babaria Sneha Samir , Dayal Anupama , Thakkar Himali P , Joshi Deepak S
Published: September 2022

Gastrointestinal Stromal Tumours (GISTs) are rare tumours of the Gastrointestinal Tract (GIT), consisting of <1% of all primary GIT neoplasms. Recent studies show an increased incidence, which may be due to improved diagnostic facilities. In contrast to the literature’s judgement and the findings of many Western research, which state that the stomach is the most common place, it was observed that the small intestine was more common. Consequently, the goal of this case series was to characterise the clinicopathological, histomorphological, and immunohistochemical spectrum of GISTs as well as their risk categorisation in accordance with the modified Miettinen and Lasota’s algorithm. Eight patients with GISTs diagnosed between January 2017 and December 2020 at tertiary care centre of Gujarat, India are presented in this case series. There was one young woman among the patients, others were middle or old age male or female and had a median age of 58.5 years. The most typical presentation was abdominal pain, albeit in one instance it was an unexpected discovery. One example of extra Extra GISTs (EGIST), where there were several retro and intraperitoneal masses, and one small intestinal GIST each had lymphoma as the tentative clinical diagnosis. Predominant spindle cell morphology was observed in contrast to other studies. Even if molecular studies are not available in resource-limited countries, the basic Immunohistochemistry (IHC) panel is the most useful in the final diagnosis. Risk stratification criteria are helpful for prognostication and further management with the use of appropriate targeted therapies.
Superficial Fungal Infections among School Age Children: Does Prevalence and Pattern Differ between Commercial and Agrarian Communities?
Authors: Onubogu Chinyere Ukamaka , Ushie Simon Nkpeh , Aghanya Iloduba Nnaemeka , Ugochukwu Ebele Francesca
Published: September 2022

Background: Superficial fungal infections (SFIs) are common and have considerable negative impact on school children in tropics.

Objectives: The study compared the prevalence and pattern of SFI among primary school pupils in an agrarian (Ukpor) and commercial (Nnewi) communities in Nnewi Area.

Methodology: A cross-sectional study was conducted among primary school pupils in Nnewi Area. Subjects were selected using stratified random sampling technique. Data was analyzed using SPSS version 21.

Results: Final analysis involved 773 and 789 pupils in the agrarian and commercial communities, respectively. Their mean age was 9.0 ±2.0 years and male: female ratio was 1:1. The agrarian community had a significantly higher proportion of children who were from low socio-economic class families, and had poorer hygiene practices (p=0.000). The overall prevalence of SFIs was 28.9%. Prevalence was significantly higher in the agrarian compared to commercial community (39.3% versus 18.6%; p = 0.000). Tinea capitis was the predominant form of SFIs accounting for 80.3% and 83.7% of SFIs cases in the agrarian and commercial communities, respectively. Black dot tinea capitis was the commonest variant of tinea capitis in both communities. Of the variants of tinea capitis, only the diffuse scale type differed in the rate of occurrence in the two communities (6.3% in agrarian versus 0.0% in commercial communities, p=0.023). The most prevalent organisms were T. tonsurans (37.9%), T. mentagrophytes (28.8%) and T. rubrum (18.7%) of which T. rubrum was significantly higher in the commercial community (27.6% versus 14.9%, p=0.036).

Conclusion: The burden of SFI is high among primary school children in Nnewi area, especially among those in agrarian communities. More awareness should be created on the prevention, identification and treatment.
Evaluation of the Agromet Indices Impact on Cowpea Crop at Khurdha District of Odisha, India
Authors: Beck Manoj Kumar , Agrawal Nickey , Janghel Yogesh , Patel Anil , Sahu Kamlesh
Published: September 2022

At the ICAR-IIWM research farm in Odisha, a study was carried out during the rabi season to assess the effects of agromet indices on the cowpea variety Kashi uttam during the two growth seasons of 2018–19 and 2019–20. Different growing seasons and a delay in sowing had a significant impact on the length of phenological stages and accumulation of agro-climatic indices (Growing Degree Days, Photothermal Units, and Heliothermal Units). The findings showed that distinct growth phases at the second growing season were responsible for the greater GDD and PTU. However, the decrease in HTU during the second growing season showed that the crop required fewer heat units as a result of the second growth season's considerably lower number of sunshine hours. Among the seasons and sowing dates, the meteorological indices accretion was perceived in 2nd growing season as compared to 1st growing season crop. Second season crop had sown earlier and get highest heat use efficiency.
Response of Growth and Production of Red and Green Okra Plants to Effect of Organic Fertilization
Authors: Purbajanti Endang Dwi , Fuskhah Eny
Published: September 2022

The effect of nitrogen on growth, and development of plants, metabolism, dry matter production has been well investigated. Extensive research has been conducted on organic fertilizers especially, i.e. the compost. This study investigated the effect of compost on okra pods yield, nitrogen agronomic use efficiency, supplied of nitrogen recovery efficiency and supplied nitrogen physiological efficiency in okra (Abelmoschus esculentus L. Moench). A completely randomized experimental design of 2x4 factorial patterns with three replications was used in this study. Factor (I) was the okra species (Green okra - Red okra) and factor (II) was the doses of compost (0, 50, 100 and 150 kg N ha−1). Kind of okra has different effects on the parameters observed. Results showed that green okra and red okra showed increased yield due to the increase in the nitrogen dose through compost. Agronomic use efficiency of green okra and red okra increased with increasing doses of compost. The nitrogen recovery efficiency of green okra and red okra also, increased with increasing doses of compost. Nitrogen physiological efficiency of green okra and red okra increased with increasing compost doses. An increase in compost doses resulted in increased nitrogen uptake, pods yield, Agronomic efficiency, nitrogen recovery efficiency and nitrogen physiological efficiency of both green and red okra. Increased compost doses resulted in decreased nitrogen use efficiency in green okra. Green okra is more efficient in using organic nitrogen from compost.
A comparative analysis of deep learning architectures with data augmentation and multichannel input for locoregional breast cancer radiotherapy
Authors: Klarenberg Rosalie , Bakx Nienke L. M. , Hurkmans Coen W.
Published: February 2025

Purpose

Studies on deep learning dose prediction increasingly focus on 3D models with multiple input channels and data augmentation, which increases the training time and thus also the environmental burden and hampers the ease of re‐training. Here we compare 2D and 3D U‐Net models with clinical accepted plans to evaluate the appropriateness of using less computationally heavy models.

Methods

A 2D Attention U‐Net, a 2D HD U‐Net, and a 3D U‐Net were trained using 1 or 5 input channels with or without data augmentation and data from 89 locoregional breast cancer patients. Results were compared to clinically accepted plans. The significance of inclusion of more channels or data augmentation was compared to the base models and the HD U‐Net and Attention U‐Net were compared to their respective identically trained counterparts.

Results

The Attention U‐Net reached fewest PTV clinical goals (28%, mostly due to a too high average breast PTV dose) and improved using significantly using five channels and augmentation (49%). The HD U‐Net already fulfilled 70% of the PTV goals, which did not improve much by adding more channels or augmentation. The 3D U‐Net with five channels and augmentation reached 76%, compared to 81% in the clinically accepted plans. The lower rates for the HD U‐Net compared to the 3D U‐Net and clinical plans were mainly caused by a lower PTVn1n2 D98%, which was still on average 93%. Organ‐at‐risk goals were met in most cases for all models. Training time was approximately 8 fold for the 3D model.

Conclusions

Comparable results to a 3D U‐Net and clinical plans can be reached with a 2D HD U‐net for a dataset size commonly seen in clinical practice. The Attention U‐Net did profit from adding extra channels and data augmentation but did not reach the same level of accuracy as the other models.
High Strength and Low Yield Anisotropy of Hot‐Extruded Mg‐2.35Nd‐1.32Gd‐0.18Zn‐0.32Zr Alloy Sheet via Cold Rolling and Subsequent Aging Heat Treatment
Authors: Kan Zhiyong , Yang Guangyu , Guo Jing , Wang Chunhui , Qin He , Jie Wanqi
Published: February 2025

In the article, microstructure, texture, and room‐temperature mechanical properties of the hot‐extruded Mg‐2.35Nd‐1.32Gd‐0.18Zn‐0.32Zr alloy sheet subjected to cold rolling and subsequent aging heat treatment are investigated. It is found that the extruded experimental alloy sheet exhibits homogeneous microstructure and extrusion direction‐split texture, and approaching room‐temperature mechanical properties along extrusion and transverse directions. The rare‐earth texture component deflects toward the basal texture component, resulting in a relative mitigation of texture differences between extrusion and transverse directions after cold rolling. Subsequent aging heat treatment significantly alleviates severe stress concentration near the grain boundaries, and precipitates many fine β1 phase within grains. The yield strength and ultimate tensile strength in the extrusion direction of extruded experimental alloy sheet significantly increase from 150 and 230 MPa to 312 and 347 MPa after cold rolling and subsequent aging heat treatment, respectively. Meanwhile, the yield strength ratio between extrusion and transverse directions improve from 0.92 to 1.03, which is mainly attributed to the texture evolution and the different strengthening effects of the β1 precipitates on basal  and prismatic  dislocations. Grain boundary and precipitation strengthening are inferred as the dominant strengthening mechanisms, accounting for about 75% to the yield strength.
Accelerating Sulfur Conversion Kinetics by Topological Semimetal Electrocatalysts Pd3Sn for High‐performance Li‐S Batteries
Authors: Zhang Yuhao , Zhang Xiuquan , Liu Guo , Su Meixia , Lin Yuan , Jiang Haiqing , Li Yuanbo , Wu Qingfeng , Wu Tianyu , Qiu Shuocheng , Tao Kun , Xie Erqing , Zhang Zhenxing
Published: February 2025

The shuttle effect and sluggish reaction kinetics of soluble lithium polysulfides (LiPSs) significantly impede the practical application of lithium‐sulfur (Li‐S) batteries. Topological semimetals (TSMs) offer a promising solution to these challenges due to their unique topological surface states. This study synthesizes reduced graphene oxide (rGO)‐loaded Pd3Sn TSMs (Pd3Sn@rGO) that are prepared by the NaBH4 reduction method. The obtained Pd3Sn@rGO composite has a notably stronger adsorption capability for LiPSs than pure rGO verified by adsorption experiments and density functional theory (DFT) calculations. The topological surface states of Pd3Sn facilitate the acceptance of electrons from Li2S6 during the adsorption process, thereby enhancing adsorption and accelerating redox reactions. Furthermore, Li2S deposition experiments confirm the effective catalytic role of Pd3Sn@rGO in the nucleation process of Li2S. Consequently, Li‐S batteries with Pd3Sn@rGO modified separators showcase exceptional rate performance across various current densities along with impressive cycling stability (decay rate of 0.0598% per cycle at 1C). This work highlights the capability of Pd3Sn in catalyzing sulfur redox reactions and underscores the potential of other TSM electrocatalysts in enhancing the performance of Li‐S batteries.
Full‐Spectrum Carbon Dots Electroluminescent White Light‐Emitting Diodes with a Record Color Rendering Index of 94
Authors: Li Dan , Wang Zhibin , Zheng Song , Jiang Naizhong , Feng Chengcai , Wu Ximing , Huang Hailiang , Pang Tao , Zeng Lingwei , Zhang Ruidan , Huang Feng , Chen Daqin
Published: February 2025

Carbon dots (CDs) are emerging as promising nanomaterials for next‐generation white electroluminescent devices due to their high photoluminescence quantum yield (PLQY), broad emission spectrum, and compatibility with solution‐processed methods. However, current CD‐based white light‐emitting diodes (CDs‐WLEDs) heavily rely on costly commercial host materials and struggle with low color rendering index (CRI). Herein, a “dual‐phase CDs emitter” strategy is introduced to achieve full‐spectrum white light emission, without employing commercial host materials. As a proof of concept, CDs are synthesized with broadband green emission and nearly 100% PLQY. Spectroscopic and structural analyses confirm that their luminescence originates from molecular state emission. By combining these green CDs with carbon quantum dot organic frameworks capable of dual blue and red emissions, white light is successfully produced with a record CRI of 94 and color coordinates of (0.32, 0.34). This approach provides a cost‐effective and efficient pathway for developing high‐performance WLEDs that rely exclusively on CDs.