bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative cytogenetic survey of the giant bonytongue Arapaima fish (Osteoglossiformes: Arapaimidae), across different Amazonian and Tocantins/Araguaia River basins
Authors: Oliveira Ezequiel A. de , Sassi Francisco de M. C. , Perez Manolo F. , Bertollo Luiz A. C. , Ráb Petr , Ezaz Tariq , Hatanaka Terumi , Viana Patrik F. , Feldberg Eliana , Oliveira Edivaldo H. C. de , Cioffi Marcelo de B.
Published: November 2020

Abstract The South American giant fishes of the genus Arapaima, commonly known as pirarucu, are one of the most iconic among Osteoglossiformes. Previously cytogenetic studies have identified their karyotype characteristics; however, characterization of cytotaxonomic differentiation across their distribution range remains unknown. In this study, we compared chromosomal characteristics using conventional and molecular cytogenetic protocols in pirarucu populations from the Amazon and Tocantins-Araguaia river basins to verify if there is differentiation among representatives of this genus. Our data revealed that individuals from all populations present the same diploid chromosome number 2n=56 and karyotype composed of 14 pairs of meta- to submetacentric and 14 pairs of subtelo- to acrocentric chromosomes. The minor and major rDNA sites are in separate chromosomal pairs, in which major rDNA sites corresponds to large heterochromatic blocks. Comparative genomic hybridizations (CGH) showed that the genome of these populations shared a great portion of repetitive elements, due to a lack of substantial specific signals. Our comparative cytogenetic data analysis of pirarucu suggested that, although significant genetic differences occur among populations, their general karyotype patterns remain conserved.
Electric eels galore: microsatellite markers for population studies
Authors: Souza-Shibatta Lenice , Ferreira Dhiego G. , Santos Kátia F. , Galindo Bruno A. , Shibatta Oscar A. , Sofia Silvia H. , Giacomin Renata M. , Bastos Douglas A. , Mendes-Júnior Raimundo N. G. , Santana Carlos David de
Published: November 2020

Abstract Fourteen novel microsatellite loci are described and characterized in two species of electric eels, Electrophorus variiand E. voltaifrom floodplains and rivers of the Amazon rainforest. These loci are polymorphic, highly informative, and have the capacity to detect reliable levels of genetic diversity. Likewise, the high combined probability of paternity exclusion value and low combined probability of genetic identity value obtained demonstrate that the new set of loci displays suitability for paternity studies on electric eels. In addition, the cross-amplification of electric eel species implies that it may also be useful in the study of the closely related E. electricus, and to other Neotropical electric fishes (Gymnotiformes) species as tested herein.
CLINICAL, DEMOGRAPHIC, ANATOMOPATHOLOGICAL, AND MOLECULAR FINDINGS IN PATIENTS WITH MEDULLOBLASTOMA TREATED IN A SINGLE HEALTH FACILITY
Authors: Hoffmann Iva Loureiro , Cardinalli Izilda Aparecida , Yunes José Andrés , Seidinger Ana Luiza , Pereira Ricardo Mendes
Published: November 2020

ABSTRACT Objective: To describe the clinical, demographic, anatomopathological, molecular, and survival characteristics of patients with medulloblastoma. Methods: Retrospective study based on patient information obtained from the review of medical records. Overall and event-free survival were analyzed using the Kaplan-Meier estimator, and the curves were compared by the log-rank test. Results: Among the patients investigated, 70 were male (66%), and age at diagnosis ranged from 2 months to 22 years. The most frequent signs and symptoms were headache (80.8%) and vomiting (75.8%). Regarding treatment, most patients (63.2%) underwent complete surgical resection, with a predominance of classic histology (63.2%). The 5-year overall survival rate was 67.9%, and the 10-year rate was 64.2%. Patients with molecular profile characteristic of the wingless (WNT) subgroup had a better prognosis, with 5-year overall survival of 75%. Conclusions: The clinical, demographic, anatomopathological, and molecular characteristics of patients with medulloblastoma described in the present study were mostly similar to those reported in the literature. Patients submitted to complete tumor resection had better clinical outcomes than those who underwent incomplete resection/biopsy. Patients classified as high-risk showed worse overall and event-free survival than those in the standard-risk group, and the presence of metastasis at diagnosis was associated with recurrence.
The importance of Serra do Mar State Park for liverworts conservation in the Atlantic Rainforest
Authors: Prudêncio Renato Xavier Araújo , Mello Zélia Rodrigues de , Costa Denise Pinheiro da
Published: November 2020

Abstract Serra do Mar State Park (PESM) is located in southeastern São Paulo state, Brazil, and is the largest Atlantic Rainforest conservation area in the country. The park is divided into 10 nuclei, and the Itutinga-Pilões nucleus (NIP) was selected for study since no survey of liverworts species richness had yet been conducted there. The floristic similarities between the NIP and different areas of Atlantic Rainforest in São Paulo state were also assessed. One hundred and eighty liverworts species were identified in the three vegetation types (lowland, submontane, and montane ombrophilous forests) encountered in the NIP, distributed among 62 genera and 21 families. Lejeuneaceae showed the highest species richness with 80 species. The high number of epiphyllous species found in the study area (26% of all species) was notable. In terms of their worldwide distributions, 57% of the species are Neotropical. Clustering analysis showed that the areas of the PESM and Jureia-Itatins Ecological Station were grouped together with the highest similarity values. The liverworts flora of the NIP demonstrates the importance of that nucleus for the conservation of liverworts diversity in the Atlantic Rainforest of the São Paulo state, as well as in Brazil.
Flora do estado do Rio de Janeiro: Myrciaria, Neomitranthes e Siphoneugena (Myrtaceae)
Authors: Caldas Diana Kelly Dias , Baumgratz José Fernando Andrade , Souza Marcelo da Costa
Published: November 2020

Resumo Apresenta-se o estudo taxonômico dos gêneros Myrciaria (5 spp.), Neomitranthes (5 spp.) e Siphoneugena (4 spp.) na flora do estado do Rio de Janeiro. Consultou-se a literatura especializada e coleções dos principais herbários do estado, incluindo imagens digitalizadas on line e tipos nomenclaturais, e realizaram-se expedições a campo para observação e coleta de amostras. Apresenta-se chaves de identificação, descrições, comentários, ilustrações e mapas de distribuição para as 14 espécies estudadas. A maioria das espécies ocorre em Floresta Ombrófila Densa, sendo algumas encontradas também em Restinga. Todas as espécies são encontradas em várias Unidades de Conservação. Características da inflorescência e florais distinguem os gêneros, enquanto as espécies são distintas por características dos ramos, folhas, inflorescências, brácteas, bractéolas, cálice e número de óvulos por lóculo. Também são propostas lectotipificações para Myrciaria disticha, Eugenia guaquiea e Eugenia tenella, e um novo sinônimo (Myrciaria tenella var. elliptica) e registrados novos locais de ocorrência no estado fluminense para 10 espécies.
Lateral and apical root resorption in teeth orthodontically moved into edentulous ridge areas
Authors: Ramos Adilson Luiz , Poluha Rodrigo Lorenzi , Guilherme Pablo , Khoury Gabriel Araújo , Rosa Junior Joao Marcos Pedro
Published: November 2020

ABSTRACT Objective: The present study aimed at comparing the external lateral root resorption (ELRR) and external apical root resorption (EARR) between teeth moved through the atrophic edentulous ridge and those undergoing the usual orthodontic movement. Methods: Fifty-four premolars were evaluated, where 27 of them had been moved toward the edentulous ridge (Group 1) and 27 from the same patient, had not been translated, which comprised the control group (Group 2). ELRR was evaluated by 0-3 scores and EARR was evaluated by 0-4 scores, before and after movement. Measurements were compared by Kruskal-Wallis and Student-Newman-Keuls tests. Results: ELRR increased statistically only in the Group 1 (p< 0.05). After orthodontic treatment, it was observed that almost 56% (n = 15) of teeth in Group 1 presented scores 2 and 3, while Group 2 presented scores 2 and 3 in about 11% (n= 3) of the teeth. EARR increased in both groups after orthodontic movement, however, statistically analyses showed no significant differences between groups (p> 0.05). Conclusions: Orthodontic movement into the atrophic edentulous ridge is subject to a greater lateral external root resorption.
Changes in nasal septum morphology after rapid maxillary expansion: a Cone-Beam Computed Tomography study in pre-pubertal patient
Authors: Bruno Giovanni , Stefani Alberto De , Benetazzo Celeste , Cavallin Francesco , Gracco Antonio
Published: November 2020

ABSTRACT Introduction: Nasal septum deviation (NSD) is the most common structural cause of nasal obstruction, affecting around 65-80% of the adult population. Rapid maxillary expansion (RME) is currently used for treatment of maxillary transverse deficiency, but can also influence nasal cavity geometry. Objective: The present study aimed at evaluating the changes in NSD by using Cone-Beam Computed Tomography (CBCT) scans in pre-pubertal patients treated with RME. Methods: This retrospective exploratory study evaluated 20 pre-pubertal patients (mean age 10 ± 2 years) who were treated for transverse maxillary constriction with RME and presented mild/moderate NSD as an incidental finding. The outcome measures were NSD tortuosity and area. These measures were obtained from transverse and coronal views of records taken before and after RME treatment. Intra-rater reliability was also assessed with intraclass correlation coefficient. Results: NSD was mild in thirteen patients (65%) and moderate in seven (35%). NSD tortuosity index did not significantly change over time (mean difference 0.002 mm/year, 95% CI; p = 0.58). NSD area did not significantly change over time (mean difference 2.103 mm2/year, 95% CI; p = 0.38). Intraclass correlation coefficient was 0.73 (95% CI) for NSD tortuosity and 0.84 (95% CI) for NSD area. Conclusions: NSD tortuosity and area suggested potential changes in NSD with small clinical relevance in pre-pubertal patients who were treated with RME. Additional studies using CBCT scans in larger samples are required to clarify the role of RME in NSD treatment.
Condições de vida de mulheres quilombolas e o alcance da autonomia reprodutiva
Authors: Fernandes Elionara Teixeira Boa Sorte , Ferreira Sílvia Lúcia , Ferreira Cláudia Suely Barreto , Cardoso Verônica Barreto
Published: November 2020

Resumo Objetivo explicar a interferência das condições de vida de mulheres quilombolas na autonomia reprodutiva. Método trata-se de um estudo qualitativo com 10 mulheres quilombolas com idade entre 23 e 49 anos, residentes em comunidades rurais do Território de Identidade da Bahia Sertão Produtivo. Estas compareceram aos encontros e assinaram o Termo de Consentimento Livre e Esclarecido. Os dados foram coletados através de grupos focais e analisados pela análise temática de Bardin. O software NVivo foi utilizado para organização dos dados. Procedeu-se à coleta de dados após a aprovação do Comitê de Ética em Pesquisa. Resultados Considerando o fato de que metade do quantitativo de mulheres era primigesta, a maioria usava contraceptivo oral, não usava preservativo e nem participava do planejamento reprodutivo. Os dados revelaram que a autonomia reprodutiva das mulheres quilombolas sofre interferência do patriarcado, entretanto, vem se remodelando com a independência financeira das mulheres. Após agregação das unidades de registro, emergiram três categorias: “Teria que casar e ter filho(a)!”, “Marcas da submissão e a conquista da autonomia” e “Planejamento reprodutivo: conflitos entre liberdade e obrigação”. Conclusão e implicações para a prática condições de vida desfavoráveis impedem mulheres quilombolas de vivenciarem a autonomia reprodutiva em plenitude; o conhecimento dessas condições poderão revelar reais necessidades de saúde reprodutiva e subsidiar ações direcionadas a este público.
Construção e validação de tecnologia educacional para promoção do aleitamento materno no período neonatal
Authors: Silva Mariana Mesquita , Penha Jardeliny Corrêa da , Barbosa Izabel Cristina Falcão Juvenal , Carneiro Cristianne Teixeira , Borges José Wicto Pereira , Bezerra Maria Augusta Rocha
Published: November 2020

Resumo Objetivo Este estudo teve como objetivos construir e validar um pacote de mensagens de texto e figuras para promoção do aleitamento materno no período neonatal. Métodos tratou-se de um estudo metodológico, realizado em quatro etapas: revisão integrativa da literatura, construção de pacote de mensagens e figuras, análise de legibilidade e validação de conteúdo e aparência. Para validação, participaram 11 juízes com expertise em aleitamento materno. O critério para validação foi concordância superior a 80%, analisada por meio dos índices de validação de conteúdo e aparência. Resultados a versão final do pacote de mensagens e figuras apresentou índice de validade de conteúdo de 0,86, índice de validade de aparência de 0,85 e validade convergente com correlação de 0,73 entre o conteúdo e a aparência (p<0,01). Conclusões e implicações para a prática o pacote de mensagens de texto e figuras foi considerado válido em conteúdo, aparência e convergência para promoção do aleitamento materno, no período neonatal, constituindo tecnologia educacional adequada para ser compartilhada via mensagens telefônicas, com intuito de se aproximar das nutrizes, ajudando-as a reagir frente aos problemas comuns no período neonatal.
“Eles pensam que a gente é invisível”: gênero, trabalho terceirizado e educação jurídica popular
Authors: Dutra Renata Queiroz , Coelho Ilana Barros
Published: November 2020

Resumo Nesse artigo analisam-se as condições de precarização do trabalho entre as trabalhadoras terceirizadas da limpeza da Universidade Federal da Bahia - UFBA. Partindo dos diários e dos relatórios produzidos na experiência do curso de formação em direitos humanos e cidadania “Promotoras Legais Populares e Coletivo Madás”, foi possível analisar empiricamente como os marcadores de gênero e raça aprofundam processos de exclusão inerentes à terceirização.
As políticas migratórias brasileiras do século XIX ao século XXI: uma leitura biopolítica do movimento pendular entre democracia e autoritarismo
Authors: Wermuth Maiquel Ângelo Dezordi
Published: November 2020

Resumo O artigo tematiza o movimento pendular entre democracia e autoritarismo que permeia historicamente as políticas migratórias brasileiras. Analisa os projetos imigrantistas do século XIX - cujo escopo era o “branqueamento” da população nacional -, passando pelas políticas restritivas adotadas na primeira metade do século XX e que culminaram, na década de 1980, na edição do Estatuto do Estrangeiro (Lei nº 6.815/1980), marcado pela construção da imagem do imigrante como “sujeito de risco” à soberania e à segurança nacional, bem como por uma nítida separação entre os imigrantes considerados “úteis” e “inúteis” de acordo com as exigências do mercado de trabalho. Avalia em que medida essas características autoritárias ainda se fazem presente na contemporaneidade, após a edição da nova Lei de Migração (Lei nº 13.445/2017), a qual, mesmo apresentando uma ruptura paradigmática orientada à promoção dos Direitos Humanos dos migrantes, ainda encontra óbice à sua efetivação, particularmente em face do seu próprio Decreto regulamentador (Decreto nº 9.199/2017), marcado por inúmeros retrocessos, evidenciando uma retomada da perspectiva autoritária na gestão da imigração com destino ao Brasil, a qual ganha novo impulso com o rompimento do país com o “Pacto Global Para Migração Segura, Ordenada e Regular” da Organização das Nações Unidas. O marco teórico que orienta a construção do artigo é a biopolítica de matriz foucaultiana e agambeniana. O método de pesquisa empregado na investigação é o fenomenológico-hermenêutico.
Orientaciones feministas para un nuevo derecho del trabajo
Authors: Lerussi Romina Carla
Published: November 2020

Resumen En el presente texto propongo dos orientaciones epistemológicas feministas que entiendo útiles para un nuevo derecho del trabajo. La primera general a partir del sintagma teoría feminista del derecho del trabajo. La segunda particular denominada trabajo sucio. Ambas dan cuenta no sólo de la matriz heterojurídica interseccionada que nos regula, sino de las implicancias entre lo remunerado y lo no remunerado en la definición de trabajo, de sujeto de derecho y de derecho del trabajo, como entrada estratégica al derecho en su conjunto.
Weed interference on nutrient accumulation in the leaves of cassava under no-tillage or conventional tillage
Authors: Ramella João Ricardo Pompermaier , Barbosa Jaqueline de Araújo , Ferreira Silvio Douglas , Fey Emerson , Costa Neumarcio Vilanova da
Published: November 2020

Abstract: The objective of this work was to evaluate the effect of weed competition on the accumulation of nitrogen and phosphorus in the leaves and on the dry weight of the roots of cassava (Manihot esculenta) in the conventional and no-tillage systems, in two crop cycles. The experiments were carried out in a randomized complete block design, with split-split plots and four replicates. The plots consisted of conventional tillage or no-tillage; the split plots, of the competition or not with weeds; and the split-split plots, of the evaluation periods (0, 25, 50, 75, 100, 125, 150, 175, 200, and 225 days after planting/pruning). In the first cycle, weed competition reduced the accumulation of nitrogen in 82.6 and 81.3% and of phosphorus in 65.7 and 85.3% under conventional tillage and no-tillage, respectively. In the second cycle, the reductions in the accumulation of nitrogen were of 41.1 and 52.4% and of phosphorus of 44.1 and 52.6%, in conventional tillage and no-tillage, respectively. The root dry weight of cassava grown with weed competition showed reductions of 15.8 and 11.2% under conventional tillage and no-tillage, respectively, only in the second cycle. Weed competition reduces the accumulation of nitrogen and phosphorus in the leaves of cassava in the conventional and no-tillage systems in both crop cycles, but reduces the dry matter of cassava roots only in the second cycle.
Magnitude e determinantes da mortalidade neonatal e pós-neonatal em Goiânia, Goiás: um estudo de coorte retrospectivo, 2012
Authors: Saloio Caio Átila , Morais Neto Otaliba Libânio de , Gonçalves Dayanne Augusta , Bessa Hugo Estevam Marques , Coelho Júnior Jadson Pinheiro , Afonso May Socorro Martinez , Carvalho Simone Resende de
Published: November 2020

Resumo Objetivo: Estimar a magnitude e determinantes da mortalidade infantil neonatal e pós-neonatal em Goiânia, Brasil, em 2012. Métodos: Estudo de coorte retrospectiva, utilizando relacionamento entre o Sistema de Informações sobre Nascidos Vivos e o Sistema de Informações sobre Mortalidade. Aplicou-se regressão logística para avaliar os fatores associados ao óbito neonatal e pós-neonatal. Resultados: A mortalidade neonatal (0-27 dias de vida) foi de 9,4; e a pós-neonatal (28-364 dias de vida), de 3,0 óbitos/1 mil nascidos vivos. Os fatores associados à mortalidade neonatal foram: 0-3 consultas de pré-natal (OR=13,10 – IC95% 7,48;22,96); gestações de 19-34 semanas (OR=6,25 – IC95% 2,26;17,29); peso ao nascer <1.500g (OR=62,42 – IC95%22,72;171,48); e parto cesáreo (OR=0,54 – IC95% 0,37;0,79). Associaram-se à mortalidade no período pós-neonatal: 0-3 consultas de pré-natal (OR=4,16 – IC95% 1,51;11,43); e peso ao nascer <1.500g (OR=18,74 – IC95% 4,04;87,00). Conclusão: Baixo número de consultas, prematuridade e baixo peso foram os principais fatores de risco da mortalidade neonatal e pós-neonatal.
Estratégias e mobilidade social: o acesso de descendentes de escravos e libertos ao clero secular no bispado do Rio de Janeiro (1702-1745)
Authors: Oliveira Anderson José Machado de
Published: November 2020

Resumo: O artigo procura analisar o processo de mobilidade social de descendentes de escravos e libertos de origem africana na América portuguesa, destacando as estratégias executadas pelos grupos familiares no intuito de superar a mácula imposta pela escravidão. Nesse sentido, privilegia-se o papel da carreira eclesiástica em sociedades escravistas hierarquizadas com base em valores oriundos do Antigo Regime.
Analysis of ORC for waste heat recovery from marine engines using plate heat exchangers
Authors: Kılıç Bayram
Published: November 2020

Effective heat transfer in system components is extremely important for organic Rankine cycles (ORCs). The efficiency of heat transfer in condenser and evaporator of ORCs leads to high efficiency in ORCs. Plate heat exchangers can be used as the evaporator and condenser of an ORC system because plate heat exchangers have a high heat-transfer rate. For this reason, heat exchangers can be one of the important factors determining the efficiency of ORC systems. In this study, thermodynamic analysis of ORCs for waste heat recovery from marine diesel engines using plate heat exchangers was performed. For all operating conditions in this study, when the evaporator temperature was 175°C and the condenser temperature was 25°C, the peak efficiency of the ORC was determined to be 24% for the R123 working fluid among three different working fluids. Similarly, when the evaporator temperature was 175°C, the condenser temperature was 25°C and the mass flow rate was 42 g/s, the peak expansion power of the ORC was 2.45 kW for the R123 working fluid.
Estimation of depth and degree of mill roll surface hardening during grit texturing
Authors: Zvyagina E. Yu. , Ogarkov N. N. , Polyakova M. A. , Sukhova M. D.
Published: November 2020

The paper presents shot blasting (SB) as the most common method of arrangement of temper mills rolls surface microgeometry, providing required roughness of the cold-rolled strip. The surface riffing studies were carried out at the Willibrator industrial unit; metallographic studies were performed using MEIJI 2700 optical microscope and JSM-6490LV scanning electron microscope. Refinement of the surface layer structure during interaction of the roll material with the grit was revealed. In the work the lower bound method, one of the methods of plasticity theory, is used for theoretical analysis of the SB process. To make computations easier, the roll microcave is approximated to spherical shape. Quantitative estimates of deformation degree and the depth of hardened layer were determined by speed of the grit and hardness of the roll surface. The depth of hardened layer is obtained by the size of used grit, and to a lesser extent, by the speed of grit impact on the roll surface and textured surface hardness. It has been searched out in literature that increase in hardness by one unit leads in average to 3 % increase in resistance. Thus, SB application allows reduction of time of rolls rehandling of temper mills by 6.0 – 10.5 %, depending on application modes of rolls riffing with grit. Analysis of microstructure have shown that increase in hardness of the surface layer is a consequence of refinement of its structure in process of interaction with the grit. It has been revealed that increase in hardness of the surface layer leads to an increase in its wear resistance and fatigue strength. The authors of the work have found that at speed of 60 m/s the hardness increases by 3.5 units.
THE LEGAL ASPECTS OF PROTECTION OF CIVIL OBJECTS AND OBJECTS OF CRITICAL INFRASTRUCTURE UNDER THE CONDITIONS OF AN ARMED CONFLICT
Authors: Koropatnik I. , Beryslavska O.
Published: November 2020

The article is dedicated to the normative-legal governing of protection of civil objects and objects of critical infrastructureunder the conditions of an armed conflict, that unconditionally is the key aspect to developing the national system of firmnessand sustainability and of course the survival of the state under the conditions of hybrid threats.It has been determined that the prohibitions that are set by the norms of international humanitarian law on the impossibility toinflict damage on civil objects or objects of critical infrastructure are often violated under the conditions of armed conflict andhybrid attacks, and therefore only prohibitions will turn out to be insufficient to achieve the state of protection for a society fromuncontrolled challenges and threats.It has also been pointed out, that there’s a critical growth of the level of threats not only to the economic, but also to theecological security of Ukraine. The absence of clear assessment of the scale of demolition, the duration of the situation and thecontinuity of the physical demolition of the infrastructure and civil objects on a significant part of the territory of the Donetsk andLuhansk regions do not allow to carry out precise assessment of losses and expenditures for Ukraine. The losses inflicted andcaused by the armed conflict in the Donbass are currently being assessed by Ukraine, UN, USAID and independent experts in adifferent manner.It has been pointed out that in the course of the Antiterrorist operation and the Operation of the United Forces in the east ofUkraine, as an addition to the most frightening phenomenon – the death of people, there’re also thousands of objects ofinfrastructure damaged and destroyed including housing. Thousands of families are left homeless, or with their houses damagedto such an extent that there’s no possibility to live there in a save and regular manner. Additionally, there’re plenty of civil objectsand objects of infrastructure that have been destroyed, the networks of water, heat, gas and electricity supply, as well as objectsthat assure the flow of used water and sewage, roads objects of social and cultural purpose, such as schools, kindergartens,healthcare entities, cultural and historical monuments etc.It has been proven, that the classification of objects of critical infrastructure is to be done with the inclusion of the followingcriteria such as: their importance to carry out the vital functions; the existing threats they could be damaged by; the duration ofactivities for their reconstruction and restoring with additional stress made on the issues of establishing a legislative basis torestore and rebuilt the civil objects and objects of critical infrastructure that have been damaged as a consequence of the armedconflict.
DEFINITION, FEATURES AND STRCUTURE OF THE LEGAL CULTURE OF SERVICEMEN
Authors: Shopina I. , Volovyk V.
Published: November 2020

The article is dedicated to determining the definition, features and structure of the legal culture of servicemen.The definition of the legal culture of a serviceman is presented as a complex of judicial values, abilities and skills whichaltogether determine his legal behavior.There’re arguments provided in favor of the idea that the culture of servicemen happens to have the following features: a) avariety of the general culture of the serviceman which happens to develop in the course nurturing within the family and the initialsocialization in the system of common middle-professional education; b) is characterized by a number of layers and consists ofthe legal culture of the citizen, which includes the legal culture of a serviceman and which in its turn consists of the legal cultureof a cadet, officers, sergeants and non-commissioned officers and privates etc; c) has influence on both the behavior of theserviceman, but also the existing overall level of legal culture of military entities.Based on the analyses of the elements of the legal culture of the serviceman it was possible to determine the followingelements of its structure: а) the theoretic-legal culture (doctrinal knowledge with regard to the essence and the peculiarities oflaw, the legal norm, state, rights and freedoms of the individual and other legal phenomena, that indirectly influence the socialrelations in a state and determine the content of the generic and special legislation); b) the military-legal culture (knowledge inthe field of military law, abilities and skills in terms of his implementation in different situations in the line of duty); c) theinformational-legal culture (the complex of knowledge, abilities and skills of legally just behavior in informational relations). Itincludes a pretty broad spectrum of elements – starting with the behavior of the servicemen on the social media and finishes withthe protection of personal data of one’s subordinates; d) the linguistic-legal culture ( the complex of knowledge, ability and skills,which allow to freely operate with the foreign military terminology, including the one that is implemented in administrative,operative, and NATO material-technical standards; e) the pedagogical-legal culture (the complex of special methods and meansto develop knowledge, abilities and skills, value orienteers and persuasions based on the realization of the rule of law among thesubordinates and other servicemen).
APPLICATION OF GIS AND REMOTE SENSING OF THE EARTH FOR THE FOREST FIRE MONITORING
Authors: Zatserkovnyi V. , Savkov P. , Pampukha I. , Vasetska К.
Published: November 2020

The paper considers the problems of the forest industry, namely forest fires. Emphasis is placed on the suffering of theforests of Ukraine from large-scale fires. The main factors in reducing forest areas are forest fires. Despite the constantimplementation of preventive and precautionary fire-fighting measures, fires affect large areas of forests, which places a heavyburden on the country's budget. In addition to direct detection of fires, assessment of their power and development forecast, theurgent task is to monitor the parameters of fires: area, perimeter of the edge and radiation power of the fire, damage,quantification of vegetation changes and more. The ability to determine the areas burned during large forest fires, allows you tomake an inventory of the post-fire condition of forests. An important task of both economic and strategic nature is the study ofdynamic changes and the state of forests. Highly informative observations from artificial satellites of the Earth make it possible to quickly and objectively assess the reserves of forest resources and investigate changes in them: fires, damage assessments,reforestation in fires and deforestation, clarification of estimates of forest damage by diseases and pests, fires, identification ofcutting activities for the purpose of further control of their legality, solution of inventory problems, assessment of forest cover ofterritories, mapping of forest cover of areas and breed structure of forests. This allows to take timely measures for the rat ionaluse of forest resources and prevent damage.
PECULIARITIES OF LAND MANAGEMENT WORKS ON THE TERRITORY OF MILITARY BASES
Authors: Savkov P. , Levinskova N. , Kryth Yu.
Published: November 2020

The article focuses on the main legal aspects of the land registry system in Ukraine. Research allowed to identify theshortcomings of the existent, inefficient land registry system, which significantly increase the conflict potential of land matters.The article also covers the preconditions needed for the establishment of an ef ficient land registry system based on the lessonslearned from land surveying activities of the Ministry of Defense. Moreover, it provides a comprehensive description of thecurrent state of the national land registry system of Ukraine. The paper highlights factors enabling the development of a cohesivesystem of measures, that would allow to significantly improve management of the land registry system of Ukraine. A list ofreasons has been provided, justifying a lack of an all-encompassing registration of the military land parcels of the Ministry ofDefense of Ukraine. Besides, many other topical issues related to the military land were identified, including systematicshortcomings that intervene with the comprehensive and legal usage of real estate assets of the Armed Forces of Ukraine. Inorder to ensure that the real estate and land parcel management system conforms to the law, preconditions for the establishmentof a computerized military land and real estate registration system were identified. Research findings included suggestionsrelated to the establishment of land management, registry and land registration center in the structure of MOD, which would dealwith issues related land management, registry and land registration. To ensure direct control and timely response such centerwould have subordinated detachments. The article provides a list of suggestions for the establishment of an efficient controlover the land fund of the Armed Forces of Ukraine, which will not only simplify the process of stock taking, but also will speed upthe process of land parcel transfer to the Ministry of Defense of Ukraine.
ECOLOGICAL MONITORING ON THE BASIS ARCGIS GEOGINFORMATION PLATFORM
Authors: Fedchenko O. , Kulynych I. , Storublov O.
Published: November 2020

Ever-changing parameters of the Earth's atmosphere and environment under the influence of anthropogenic load, the activityof industrial and military facilities demands the necessity for reliable assessment of the ecological condition and its forecastingin order to ensure environmental safety. This involves forecasting the further development of favorable situations or negativeconsequences and making adequate decisions based on the use of environmental monitoring using automated systems(decision support systems) for environmental monitoring. The main function of such systems is the complex automation of allprocesses related to the collection, accumulation and maintenance of various environmental registration information, in ensuringthe possibility of its further processing on the basis of modern information technologies. regardless of the level of environmentalmonitoring, the interconnection of individual units is required: observation, information collection, assessment of the actual stateof the object of observation, forecast of the future state and its assessment, management, regulation of environmental quality, foreffective system operation. The use of environmental monitoring subsystems on a single geographic information basis indecision support systems will significantly reduce the time required to respond quickly to crises, which will increase theefficiency of decision-making to achieve the relevant goals and objectives. The information can be transmitted most quickly overthe Internet, and the output interface should be convenient (ergonomic), not overloaded with unnecessary data and independentof the installation of specialized software.The modern full-featured geographic information platform ArcGIS allows to build not only a geographical information systemof any scale and purpose, but also to form on its basis an effective system of ecological monitoring.
Method Of Polarographic Determination Of Platyphylline In A Form Of N-Oxide And Its Validation In Solution For Injection
Authors: Dubenska L.O. , Dushna O.M. , Plyska М.V. , Blazheyevskіy M. Ye.
Published: November 2020

A new approach was studied for determination of alkaloid Platyphylline in a form of N-oxide by reduction current on the dropping mercury electrode. The optimal conditions were selected for chemical transformation (using of potassium peroxymonosulfate) of Platyphylline into N-oxide and with following product reduction on the electrode. On this basis, the methods of determination of Platyphylline in the solution for injections and in tablets were developed. New methods of indication are characterized by very simple sample preparation, wide linear range, low limit of determination (2.1∙10-6 mol∙L–1), sufficient accuracy and selectivity. These methods were checked while analysing one-component solution for injections and combined drug – tablets. The obtained results of analysis were compared to those indicated in the certificate of analysis issued by testing laboratories of the State Service of Ukraine on Medicines and Drugs Control. Defined metrics vary from 97.17 to 102.02 %. The method of determination Platyphylline in the solution for injections «Platyphylline-Zdorovye» is validated (the criterion linearity, accuracy as well as precision). The validation evaluation results have proved the correctness and reliability of the developed method. The main feature of the proposed method for the determination of Platyphylline using N-oxide as an analytical form is the ability to determine directly the metabolite of Platyhylline. Consequently, the work can be adapted for the determination of N-oxide Platyphylline in plant materials.
SARM1mediates TLR9-induced vascular hyperpermeability following hemorrhagic shock
Authors: R. Doelle Morrison , M. Predmore Benjamin
Published: November 2020

Hemorrhagic shock (HS) result in multiple organ dysfunction syndrome (MODS) and inflammatory response. It is one of the world's leading causes of death within the first 40 years of life and thus a significant health problem. The exact mechanism is not clear. TLRs are stimulated both by pathogen-associated molecular patterns as well as by damage-associated molecular patterns, including trauma and hemorrhagic shock. In the present study, we investigated whether the SARM1 responsible for mediats-TLR9-induces inflammatory process and vascular hyperpermeability following hemorrhagic shock. Here we produced an in vivo model of severe hemorrhagic shock in adult wild type mice (40 ± 2 mmHg for 90 min, fluid resuscitation for 30 min) was employed. Mesenteric postcapillary venules were examined for changes in hyperpermeability by intravital microscopy. Blood samples were collected for measurement of tumor necrosis factor (TNF) using ELISA. Biopsies were obtained from organs for light microscopic examination. Our data suggest that SARM1 promising a new mechanisim of TLR9 involved in regulation of hemorrhagic shock and therapeutic target for the treatment of hemorrhagic shock.
Hepatosplenic T-Cell Lymphoma in visceral leishmaniasis young girl
Authors: F. Giannakoulas Nikolaos , Speletas Enrique
Published: November 2020

Hepatosplenic T-cell lymphoma (HSTCL) is a rare, aggressive T- cell lymphoma that is characterized by hepatosplenic and bone marrow sinusoidal infiltration of cytotoxic T cells, usually of gamma-delta (γδ) T-cell receptor type. The diagnosis was challenging as he required an extensive investigation that ultimately showed the characteristic clinical, histopathologic, and cytogenetic features of hepatosplenic T-cell lymphoma. We report a case of 12-year-old girl patient with HSTCL and visceral leishmaniasis, presented with progressive jaundice, massive hepatosplenomegaly, and weight loss. The diagnosis was required an extensive investigation that ultimately revealed the characteristically clinical, histopathological and cytogenetic features of hepatosplenic T-Cell Lymphoma. The clinical course was aggressive and multi-agent chemotherapy are used. The importance of considering it in a differential diagnosis of hepatosplenomegaly in young girl who present with constitutional symptoms and visceral leishmaniasis without lymphadenopathy.
Chronic fatigue syndrome in patient with ALK-positive anaplastic large cell lymphoma
Authors: Larsen Stephen , Junghanss Christian
Published: November 2020

Anaplastic large cell lymphoma (ALCL) is a rare type of NHL, and more common subtypes of T-cell lymphoma, we report a case of ALK-positive anaplastic large cell lymphoma preceded by long history of chronic fatigue syndrome. A 75-year-old patient recently developed cervical lymphadenopathy, pyrexia, weight loss, night sweats. Chest computed tomography scan showed widening of the superior mediastinum. Magnetic resonance imaging of the spine demonstrated spinal effacement at T7 raising the risk of cord compression. A lymph node biopsy showed positive anaplastic large cell lymphoma. Patient was treated with standard first-line chemotherapy proceed to the autologous stem cell transplantation.
Critical role of TLR-4/NF-κB pathway in upregulation mechanism of cerebral ischemia reperfusion injury of mouse
Authors: M. Florentin Jonathan , Yun Lin Yun Lin
Published: November 2020

The objective of this study is to investigate the expression of TLR-4/ NF-κB pathway in the cerebral ischemia injury of male adult mice. TLR-4 mutant (HeJ) mice and TLR-4 wild (HeN) mice were divided into the stroke model group and sham group. The stroke model was made by transient cerebral ischemia through middle cerebral artery occlusion (MCAO), while mice in the sham group were manipulated in the same way, but the MCA was not occluded. The brain tissues were collected for the morphological observation. The immunohistochemistry was employed to detect the expression of NF-κB, Western blot was used to detect the expression of TLR-4 and ELISA to detect the expression of serum pro-inflammatory mediators. The expression of NF-κB in HeJ mice after the cerebral I/R was significantly lower than that in HeN mice. For the stroke model group and sham group, the expression of TLR-4 in HeN mice was all significantly higher than that in HeJ mice, while the expression of TLR-4 in HeJ mice in the stroke model group was significantly higher than that in sham group. The expression of all pro-inflammatory mediators with HeJ was significantly lower than that in HeN mice. Together, these data concluded that TLR-4/NF-κB pathway is closely related to the cerebral I/R injury, which plays its role through the release of pro-inflammatory cytokines..
dx.doi.org/10.18081/2333-5106/016-7/253-264
Authors: Kadhim Naser , Aziz Dhifaf
Published: November 2020

DNA topoisomerases are ubiquitous, enzymes needed to control topological problems encountered during DNA replication, transcription, recombination and maintenance of genomic stability. They proved to be valuable targets for cancer chemotherapy. The seeds alkaloids extract of Rue plant (Peganum harmala L. Zygophyllaceae) were fractioned by high performance liquid chromatography as a suitable technique, HPLC waters company, gradient, Nova-Pak, C18*, 4µm, 3.9x150mm, mobile phase ACN-water pH10.7. Thirty-four separate solution depending on the retention time of eluents. The aim of this study is to investigate the trace compounds relatively and used as inhibitors for the topoisomerase II enzyme, the study the poison and suppressor model inhibitions and the synergy and antagonism activity of fractions. The visicinone, harmine, visicine and harmaline, were (2.86, 0.75, 13.14, and 16.62 mg/100mg of plant powder. The harmine ˃vicicinone˃ harmaline˃ vicicine as enzyme inhibitors. The unknown trace compounds gave the best inhibition relatively, the alkaloid fractions gave higher inhibitory units of fraction effective (FE). Results of seeds alkaloid fractions showed that the FE in state of fraction mixture was 36% inhibitory units, while summation of FE of each fraction alone gave higher level than their mixture, where sum of FE of them was 1229% inhibitory units. The suppressor inhibition model according to highest percent of the remain supercoiled DNA plasmid than production of linear and open nicked circular with high value in F8 (84%), the poisons inhibition model activity according to the highest percent of linear and nicked open circular DNA plasmid with high level in F31 (88%). There are a trace compounds within some fraction but that the effectiveness of inhibitory relatively higher than known compounds (harmine, vicisinone, harmaline, and vicisine), this can be purified and used as somewhat better inhibitors. There is antagonism activity among seed alkaloids fractions. The all fractions showed a poison and a suppressor model inhibition action in varies percentage, the suppressor inhibition appear in high value in F8 (84%), while the poisons inhibition model gave high level in F31 (88%).
Dopamine signaling attenuated myocardial injury during endotoxemia
Authors: Turler Mark , Thoma Shel
Published: November 2020

Myocardial depression is a well-recognized manifestation of organ dysfunction in sepsis, the direct protective effect of Dopamine on myocardial is still not clear. Here, we aimed to study whether Dopamine can directly protect myocardial from endotoxemia. To test that, we used adult C57/BL6 mice were treated with endotoxin (0.5 mg/kg, iv). Clozapine was administered as D2 antagonist, (intraperitoneal administration shortly before the model of sepsis). Electron microscopy, TUNEL staining, caspase-3 expression, and the Bcl-2/Bax ratio were used to measure myocardial apoptosis. Left ventricle (LV) function was assessed using a microcatheter system. Chemokines and cytokines in plasma and myocardium were analyzed by enzyme-linked immunosorbent assay (ELISA). Mononuclear cells in the myocardium were examined using immunofluorescence staining. In conclusion, our results for the first time showed the role of Dopamine to directly protect myocardial from endotoxemia through attenuated proinflammatory cytokines and partly through inhibiting apoptosis.
Investigate the role of GPR15/BOB in the SLE patients
Authors: G. Jackson Caroline , R. Kwan Donald
Published: November 2020

GPR15 functions as a cellular co-receptor for some isolates of HIV-1, HIV-2, and SIV through interactions with several viral envelope proteins. The objective of this study was to investigate the expression of orphan receptor GPR15/BOB in the serum of SLE patients and non-SLE healthy people. GPR15/BOB expression was analysed by flow cytometry while, GPR15/BOB messenger RNA was examined in peripheral blood monocytes by RT-PCR. GPR15/BOB mRNA was detected in all periphral blood of SLE patients examined. Further, a significant increase in GPR15/BOB expression as measured by mean fluorescence intensity was observed on SLE PB neutrophils compared to these cell populations from healthy donors. We concluded that GPR15/BOB is expressed in monocytes and neutrophils in peripheral blood, and expression is up-regulated in SLE patients compared to controls. GPR15/BOB may play a role in SLE pathogenesis.
Biological role of cytoplasmic transducin beta like related protein 1-induced proliferation and tumorigenicity in prostate cancer
Authors: Zheng Shu-Peng , Feng Xiang
Published: November 2020

Androgen receptor mediated transcription and function in prostate cancer and critical for prostate cell growth and gland differentiation. Transducin beta like related protein 1 (TBLR1) primarily localizes in the nucleus in benign prostate tissue and is significantly reduced in prostate cancer. The objective of this study is investigated the role of cytoplasmic TBLR1in prostate cancer. Real-time PCR, Western blotting and immunocytochemistry were used to evaluate Transducin beta like related protein 1 (TBLR1) expression in prostate cancer cell lines and normal prostate cells, tissue samples and adjacent nontumor tissues, and in 142 paraffin-embedded specimens. Immunohistochemical analysis revealed high expression of TBLR1 in 89 of 214 paraffin-embedded archival prostate cancer. The expression level of TBLR1 was significantly increased in prostate cancer both in vivo and in vitro and correlated with clinical stage (P<0.05) and metastasis (P<0.001). Over all the study showed that the TBLR1 plays a key role in the development of prostate cancer cells and TBLR1 may be prognostic marker and a potential therapeutic target in the treatment human prostate cancer.