bluuebunny/crossref_metadata_2025 huggingface dataset:
Mercury Concentration, DNA Methylation, and Mitochondrial DNA Damage in Olive Ridley Sea Turtle Embryos With Schistosomus Reflexus Syndrome
Authors: Martín-del-Campo Rodolfo , Bárcenas-Ibarra Annelisse , Lund Gertrud , Rodríguez-Ríos Dalia , Yong-Villalobos Lenin , García-Hernández Jaqueline , García-Gasca Alejandra
Published: August 2019

Schistosomus reflexus syndrome (SR) is a rare and lethal congenital malformation that has been reported in the olive ridley sea turtle ( Lepidochelys olivacea) in Mexico. Although the etiology remains unclear, it is presumed to be genetic. Since embryonic development in sea turtles largely depends on environmental conditions, we investigated whether sea turtle total mercury content participates in the etiology of SR. Given that several toxins are known to affect both DNA methylation and/or mitochondrial DNA (mtDNA) copy number, we also probed for associations of these parameters to SR and mercury exposure. We measured the levels of each variable in malformed olive ridley sea turtle embryos (either with SR or other non-SR malformations) and embryos without malformations. Malformed embryos (with or without SR) showed higher mercury concentrations compared to normal embryos, while only embryos with SR showed higher levels of methylation compared to embryos without malformations and those with other malformations. Furthermore, we uncovered a positive correlation between mercury concentrations and DNA methylation in SR embryos. With respect to mtDNA copy number, no differences were detected across experimental groups. Because of sample size limitations, this study is an initial attempt to understand the association of environmental toxins (such as mercury) and epigenetic alterations (DNA methylation) in the etiology of SR in sea turtles.
The Influence of Breastfeeding Peer Support on Breastfeeding Satisfaction Among Japanese Mothers: A Randomized Controlled Trial
Authors: Hongo Hiroko , Green Joseph , Shibanuma Akira , Nanishi Keiko , Jimba Masamine
Published: August 2019

Background

Peer support may help mothers to feel satisfied with their breastfeeding and to continue breastfeeding. However, previous researchers have not examined the influence of peer support on the three breastfeeding-satisfaction domains.

Research aim

We aimed to examine the influence of telephone-based peer support on the following three domains of breastfeeding satisfaction among Japanese mothers: maternal satisfaction, perceived benefit to the infant, and lifestyle compatibility with breastfeeding.

Methods

Breastfeeding mothers were recruited at four maternity hospitals in Japan to participate in a randomized controlled trial. Data were collected 1 month and 4 months postpartum. Among all of the participants ( N = 114), those in the intervention group ( n = 60) received telephone-based peer support until 4 months postpartum, and participants in the control group ( n = 54) received conventional support. Breastfeeding satisfaction was measured using the short version of the revised Japanese Maternal Breastfeeding Evaluation Scale. Generalized estimating equations and effect size analyses were used to examine the influence of the intervention.

Results

On the subscale measuring lifestyle compatibility, participants with peer support had a higher score than those without peer support: regression coefficient 1.54 (95% confidence interval [0.03, 3.04]). The effect size was 0.40 standard deviations among participants with low and mid-level scores at baseline.

Conclusion

Although peer support did not change maternal satisfaction or perceived benefit to the infant, it did increase lifestyle compatibility with breastfeeding among these Japanese mothers. This is evidence in favor of increasing the use of peer support.
Clinical Risk Factors of Asymptomatic Deep Venous Thrombosis in Patients With Acute Stroke
Authors: Wang Yi , Shi Yu , Dong Yi , Dong Qiang , Ye Ting , Fang Kun
Published: August 2019

Background:

Deep venous thrombosis (DVT) is a common complication after stroke. It is easy to identify the patients with symptomatic DVT; however, the tool for asymptomatic high-risk population needs to be further explored. Our aim was to explore the risk factors of acute stroke patients with asymptomatic DVT.

Methods:

We performed a prospective observation study among 452 patients with acute stroke who had a stroke within 14 days. Ultrasound examination of deep veins was repeatedly performed in each patient for DVT every 7 days during his admission. The dynamic rate of DVT in acute stroke was analyzed. Then risk factors were compared between DVT patients and non-DVT patients. The predictive model was explored based on thr cox proportion model.

Results:

Asymptomatic DVT was detected in 52 (11.5%) patients with stroke and 85.9% of thrombi were identified in their distal veins. Patients with longer length of stay ( P = .004), more severe stroke ( P = 0.001), higher level of D-dimer ( P = .003), and higher blood glucose level were associated with higher risk of DVT, while patients with higher triglyceride level ( P = .003) were less likely to have DVT, after adjusting age and sex. With the median of D-dimer (0.38 FEU mg/L) as cutoff value. Patients with higher level of D-dimer might have a higher risk of DVT with a significant statistical difference. Also, the severity of stroke differed DVT risk in Kaplan-Meier model. Using cox-proportion hazard regression model, asymptomatic DVT could be predicted (area under the curve 0.852).

Conclusion:

Our data showed that asymptomatic DVT was common in patients with acute stroke and most of thrombosis occurred in distal veins. Combination of clinical manifestation and laboratory results might be helpful predict DVT. DVT prophylaxis should be condisdered in high risk.
Spectrum of conjunctival tumours in a Spanish series: A review of 462 cases
Authors: García Onrubia Luis , Pacheco-Callirgos Gabriela Estefanía , Portero-Benito Alejandro , García-Álvarez Ciro , Carreño Salas Ester , Muñoz-Moreno M Fe , García-Lagarto Elena , Saornil-Álvarez María Antonia
Published: August 2019

Introduction:

To report the spectrum and frequency of conjunctiva tumours in an ocular oncology unit analysing the clinical profile of benign, precancerous and malignant conjunctival lesions.

Methods:

A retrospective case series of 462 consecutive patients diagnosed at the Ocular Oncology Unit of the University Hospital of Valladolid from 1992 to 2017.

Results:

Among 462 consecutive patients, the tumour was classified as melanocytic in 252 (54.5%) and non-melanocytic in 210 (45.5). Two hundred forty-eight males (mean age 51.63 (SD = 23.20)) and 214 females (mean age 48.27 (SD = 21.77)) were included. Mean patient age at diagnosis was 50.07 years (range = 1-92 years). The majority of tumours were benign (n = 307 (66.5%)) followed by precancerous (n = 103 (22.3%)) and finally by malignant ones (n = 52 (11.3%)). Benign lesions were predominantly found in younger individuals rather than premalignant (p < 0.05) and malignant ones (p < 0.05). Most of the melanocytic lesions were benign (88.5%), most epithelial ones were precancerous (61.4%) and most lymphoid lesions were malignant (56.3%). Tumours involving one or four quadrants of the ocular surface usually were benign, unlike tumours involving three quadrants that were malignant (16 (48.5%) p < 0.05). The majority of benign lesions were detected on females (n = 163 (53.1%)) by routine examination (n = 178 (86.4%)). However, main complaint in malignant tumours was the growth of the lesion (n = 39 (76.5%)).

Conclusion:

Most of the conjunctival tumours were melanocytic, mostly benign, closely followed by those of epithelial origin, with a predominance of precancerous lesions. Melanocytic, epithelial and lymphoid tumours accounted for over 90% of cases. A trend was identified with benign lesions being found in younger female patients on routine examination.
Evaluation of the Making Employment Needs (MEN) Count Intervention to Reduce HIV/STI Risk for Black Heterosexual Men in Washington DC
Authors: Raj Anita , Johns Nicole E. , Vaida Florin , Urada Lianne , Massie Jenne , Yore Jennifer B. , Bowleg Lisa
Published: August 2019

The primary aim of this study was to evaluate the impact of MEN Count, a race- and gender-tailored three-session counseling intervention, on HIV/STI incidence as well as housing and employment. A two-armed quasi-experimental design was used to compare MEN Count to an attention comparison condition focused on stress reduction, from March 2014 to April 2017. Participants ( N = 454) were Black heterosexual men in Washington DC, largely recruited from an STI clinic. Multivariate difference-in-difference regressions assessed whether the intervention was associated with significant changes in the outcomes set, which included nonviral STI incidence, sexual risk categorization, housing, and employment. Significant improvements over time were observed across both treatment arms for all outcomes ( p < .05). Reductions in unemployment were significantly greater for intervention than for control participants (AOR unemployment = 0.48, 95% CI [0.23, 0.99]). Improvements in other outcomes did not differ significantly by treatment group. In dose analyses, participants receiving all intervention sessions were significantly less likely than control participants to have experienced homelessness in the 90 days prior (AOR= 0.31, 95% CI [0.10, 0.96]) and to be unemployed (AOR = 0.37, 95% CI [0.14, 0.96]). The MEN Count intervention offers a promising approach to address structural risk factors for STI, but not STI itself, among this largely STI clinic–based sample.
Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polyps
Authors: Peng Yang , Zi Xiao-Xue , Tian Teng-Fei , Lee Bernett , Lum Josephine , Tang See Aik , Tan Kai Sen , Qiu Qian-Hui , Ye Jing , Shi Li , Guan Wei-Jie , Andiappan Anand Kumar , Wang De Yun
Published: August 2019

Introduction

The pathways underlying chronic rhinosinusitis with nasal polyps (CRSwNP) are unclear. We conducted genome-wide gene expression analysis to determine pathways and candidate gene sets associated with CRSwNP.

Methods

We performed whole-transcriptome RNA sequencing on 42 polyp (CRSwNP-NP) and 33 paired nonpolyp inferior turbinate (CRSwNP-IT) tissues from patients with CRSwNP and 28 inferior turbinate samples from non-CRS controls (CS-IT). We analysed the differentially expressed genes (DEGs) and the gene sets that were enriched in functional pathways.

Results

Principal component-informed analysis revealed cilium function and immune regulation as the two main Gene Ontology (GO) categories differentiating CRSwNP patients from controls. We detected 6182 and 1592 DEGs between CRSwNP-NPversusCS-IT and between CRSwNP-NPversusCRSwNP-IT tissues, respectively. Atopy status did not have a major impact on gene expression in various tissues. GO analysis on these DEGs implicated extracellular matrix (ECM) disassembly,O-glycan processing, angiogenesis and host viral response in CRSwNP pathogenesis. Ingenuity Pathway Analysis identified significant enrichment of type 1 interferon signalling and axonal guidance canonical pathways, angiogenesis, and collagen and fibrotic changes in CRSwNP (CRSwNP-NP and CRSwNP-IT) tissues compared with CS-IT. Finally, gene set enrichment analysis implicated sets of genes co-regulated in processes associated with inflammatory response and aberrant cell differentiation in polyp formation.

Conclusions

Gene signatures involved in defective host defences (including cilia dysfunction and immune dysregulation), inflammation and abnormal metabolism of ECM are implicated in CRSwNP. Functional validation of these gene expression patterns will open opportunities for CRSwNP therapeutic interventions such as biologics and immunomodulators.
Predictors of Clinical Success After Surgery for Primary Aldosteronism in the Japanese Nationwide Cohort
Authors: Morisaki Mitsuha , Kurihara Isao , Itoh Hiroshi , Naruse Mitsuhide , Takeda Yoshiyu , Katabami Takuyuki , Ichijo Takamasa , Wada Norio , Yoshimoto Takanobu , Ogawa Yoshihiro , Sone Masakatsu , Tsuiki Mika , Shibata Hirotaka , Kawashima Junji , Fujita Megumi , Watanabe Minemori , Matsuda Yuichi , Kobayashi Hiroki , Suzuki Tomoko ,   JPAS Study Group
Published: August 2019

Context

Aldosterone-producing adenomas are a curable subtype of primary aldosteronism (PA); however, hypertension persists in some patients after adrenalectomy.

Objective

To identify factors associated with, and develop prediction models for, blood pressure (BP) normalization or improvement after adrenalectomy.

Design

Retrospective analysis of patients treated between 2006 and 2018, with a 6-month follow-up.

Setting

A nationwide, 29-center Japanese registry encompassing 15 university hospitals and 14 city hospitals.

Patients

We categorized 574 participants in the Japan Primary Aldosteronism Study, who were diagnosed with PA and underwent adrenalectomy, as BP normalized or improved, on the basis of their presentations at 6 months postsurgery.

Main Outcome Measure

The rate of complete, partial, and absent clinical success. Predictive factors related to BP outcomes after PA surgery were also evaluated.

Results

Complete clinical success was achieved in 32.6% and partial clinical success was achieved in 53.0% of the patients at 6 months postsurgery. The following five variables were independent predictors for BP normalization: ≤7 years of hypertension, body mass index ≤25 kg/m2, no more than one antihypertensive medication, absence of medical history of diabetes, and female sex. The area under the receiver operator characteristic curve was 0.797 in the BP normalization model.

Conclusion

We established models that predicted postoperative BP normalization in patients with PA. These should be useful for shared decision-making regarding adrenalectomy for PA.
A CONTRIBUIÇÃO DO ORÇAMENTO SIGILOSO PARA A EFICIÊNCIA DAS LICITAÇÕES E CONTRATAÇÕES PÚBLICAS: UMA ANÁLISE A PARTIR DAS DECISÕES DO TCU
Authors: Forni João Paulo Gualberto , Varella Marcelo Dias
Published: August 2019

A busca por mais efi ciência no âmbito das licitações e das contratações públicas deu origem ao Regime Diferenciado de Contratações Públicas (RDC). Uma das inovações trazidas por essa norma é o sigilo dos orçamentos. O presente trabalho analisa a contribuição dessa prática para a efi ciência das licitações e das contratações públicas, defendendo sua constitucionalidade e sua adequação do ponto de vista da teoria econômica e da jurisprudência do Tribunal de Contas da União (TCU), com exceção para o regime de contratação integrada. O texto faz uma análise crítica da teoria jurídica recente e das decisões do TCU e do Tribunal de Justiça da União Europeia sobre a efetividade dos modelos de contratação criados a partir das experiências com a Copa do Mundo e com as Olimpíadas. Conclui-se que, embora existam limites importantes nos modelos adotados, estes apresentam vantagens comparativas importantes em relação à lógica anterior.
Examining the longitudinal nature of depressive symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC)
Authors: Kwong Alex S. F.
Published: August 2019

Depression during adolescence is associated with a number of negative outcomes in later life. Research has examined the longitudinal nature of adolescent depression in order to identify patterns of depressive mood, the early antecedents and later consequences. However, rich longitudinal data is needed to better address these questions. The Avon Longitudinal Study of Parents and Children (ALSPAC) is an intergenerational birth cohort with nine repeated assessments of depressive symptoms throughout late childhood, adolescence and young adulthood. Depressive symptoms are measured using the Short Mood and Feelings Questionnaire (SMFQ). Many studies have used ALSPAC to examine the longitudinal nature of depressive symptoms in combination with the wealth of early life exposure and later outcome data. This data note provides a summary of the SMFQ data, where the data are stored in ALSPAC, the characteristics and distribution of the SMFQ, and highlights some considerations for researchers wanting to use the SMFQ data in ALSPAC.
About Authors
Authors: Authors About
Published: August 2019

About Authors
Who We Are Is What Makes Us Laugh: Humour as Discourse on Identity and Hegemony
Authors: Ylagan Christian
Published: August 2019

There exists a sociocultural function to humour that is geared towards maintaining order through a subversion (or inversion) of the more serious, structured status quo, and while there is a pragmatic side to the dispensation of humour across any given society, humour can also serve a fundamentally ontological function in determining and representing a group’s identity. Though notions of social organization and culture exist and are perpetuated primarily within a group’s literary canon, as espoused for example in the privileging of genres such as the epic or the novel as loci of national identity, this paper argues that such identities can be just as effectively – if not better – constructed through popular representations in humour, especially in satirical content found in “ephemeral” mediums such as comic strips. Such representations in turn can be mobilized to complement or even dismantle the status quo and offer alternative paradigms of understanding national identities and cultural affiliations.
LA EPISTEMOLOGÍA DE LAS ABUELAS/SABIAS AFROESMERALDEÑAS Y AFROCHOTEÑAS: UNA CONSTRUCCIÓN DESDE EL ESTAR HACIENDO – EXISTIENDO
Authors: Hernández Basante Kattya
Published: August 2019

Entretejiendo distintas voces: las de abuelas/sabias afroecuatorianas, la de la autora, así como la de otras autoras y autores, el presente artículo hace un acercamiento a algunos de los principales elementos que configurarían el pensamiento/conocimiento construido por aquellas sabias mujeres. Un pensar/saber y hacer de larga vida que, sustentado en (al tiempo que sustentando) la memoria ancestral de sus pueblos, es gestado y producido en y desde sus luchas de afirmación de su humanidad negada por el proyecto “civilizatorio” moderno/colonial. En fin, un pensamiento/conocimiento construido, cotidiana y colectivamente desde el “largo ayer”, en y desde sus cuerposterritorio, en y desde sus luchas por, para y de reconstrucción de sus vidaexistencias como personas y como pueblos.
A CRÍTICA EUROCÊNTRICA NO ENSINO DE HISTÓRIA DA AMÉRICA: ABORDAGENS SOBRE A RETÓRICA LASCASIANA
Authors: Gonçalves Borges Rafael
Published: August 2019

ResumoA crítica ao eurocentrismo como paradigma epistemológico de produção e comunicação do conhecimento histórico é um tema recorrente na pesquisa e no ensino de História da América. Este texto se dedica a problematizar a importância da historiografia em América para uma crítica eurocêntrica, dando atenção especial à forma como diferentes abordagens teóricas são produzidas acerca da obra de Bartolomeu de Las Casas, frade dominicano conhecido pela sua atuação na defesa dos indígenas no México colonial e, portanto, um primeiro crítico da modernidade europeia. A ideia é comparar as reflexões produzidas na historiografia nacional de América que tecem críticas severas a uma abordagem lascasiana da colonização e da sociedade americana como um todo, com abordagens em diálogo com a teoria decolonial produzida na América Latina, com ênfase em Enrique Dussel, que oferecem uma visão mais positiva da produção do frade. No limite, propõe-se a reflexão sobre a atualidade do debate no sentido de consecução de práticas políticas contemporâneas a partir do ensino da disciplina histórica.
DIDÁTICA DA HISTÓRIA E CURRÍCULOS PARA O ENSINO DE HISTÓRIA: RELACIONANDO PASSADO, PRESENTE E FUTURO NA DISCUSSÃO SOBRE O EUROCENTRISMO .
Authors: Carlos Moreno Jean
Published: August 2019

Partindo do mal-estar produzido pela discussão da primeira versão da Base Nacional Comum Curricular (BNCC), propomos analisar as possibilidades e limites da apropriação da Didática da História ruseniana como uma das bases para pensar os currículos de História contemporâneos no Brasil e na América Latina como um todo. As potencialidades são construídas a partir do caráter conceitual do pensamento histórico, destacando as noções de sentido e orientação em sua relação com a subjetividade humana, no atendimento às exigências externas da vida prática e internas da autocompreensão identitária. As limitações estariam ligadas à própria leitura do passado e do presente latino-americano que, pela dificuldade em superar sua história recente de colonização, impõe desafios extremos de orientação em relação à construção da moderna noção de autonomia individual e coletiva.
REFLEXÕES SOBRE OS SENTIDOS DOS PASSADOS DISTANTES NA FORMAÇÃO DE PROFESSORES: O ORIENTE E A ANTIGUIDADE COMO IMAGENS MÍTICAS
Authors: Guimarães Guerra Lolita
Published: August 2019

Este trabalho tem por objetivo discutir a produção de imagens míticas do Oriente e da Antiguidade a serem consideradas na formação de professores de História. Nos preocupamos em como a História é instrumentalizada para ensejar memórias e identidades legitimadas quando há grande investimento do capital privado para tanto. Identificamos conteúdos curriculares, livros didáticos e saberes pré-profissionais não escolares que ensejam discursos estereotipados sobre identidades religiosas, de gênero e nacionais e étnico-raciais.
Honey and its antimicrobial properties
Authors: Winter George
Published: August 2019

In a world where antimicrobial resistance is taking hold, George Winter discusses the benefits of medical honey in the prevention of infection in wound care
Pollen analysis of honey samples produced in the counties of Santa Helena and Terra Roxa, western Region of Paraná, Southern Brazil
Authors: De Moraes Fernanda Jacobus , Garcia Regina Conceição , Galhardo Douglas , Camargo Simone Cristina , Pires Bruno Garcia , Pereira Diana Jessica , Sousa Paulo Henrique Amaral Araújo de
Published: August 2019

A melissopalinologia foi utilizada para determinar a origem botânica do mel, importante para sua rastreabilidade. Quarenta amostras de mel dos municípios de Santa Helena (20) e Terra Roxa (20), região oeste do Paraná, foram analisadas de acordo com os tipos de pólen e comparações com os catálogos de pólen e literatura especializada. Em relação à qualidade analítica, foram identificados 300 grãos de pólen por amostra. Nas amostras de Santa Helena, foram encontrados 71 tipos de pólen de 24 famílias, classificados como mel monofloral de Hovenia dulcis (8) e o restante como multifloral (12). Nas amostras da Terra Roxa, 64 tipos de pólen pertencentes a 29 famílias foram classificadas como Glycine max L. Merrill (7), Mimosa scabrella Benth (2),Mimosa caesalpiniifolia Benth (1), Mimosa verrucosa Benth (1), Mikania sp. (1) e Senecio sp. (1) e como multifloral (7). Os dois locais têm um alto índice de similaridade, no entanto, a predominância de alguns tipos de pólen indica a especificidade botânica da localidade. Para Santa Helena, maior significância foi observada para o pólen de H. dulcis , Eucalyptus sp. , Parapiptadenia rigida , e leucena ; em Terra Roxa, os tipos de pólen G. max , M. scabrella e Eucalyptussp. teve mais incidentes. Apesar do índice de similaridade, os indicadores mostram diferenças entre as áreas produtoras. As amostras de mel de Santa Helena apresentaram maior diversidade de pólen em relação às amostras de Terra Roxa, refletindo a cobertura vegetativa predominante de matas ciliares e culturas agrícolas, respectivamente, em cada município.
Some theoretical and empirical background to Fodor’s systematicity arguments
Authors: Aizawa Kenneth
Published: August 2019

This paper aims to clarify certain features of the systematicity arguments by a review of some of the largely underexamined background in Chomsky’s and Fodor’s early work on transformational grammar.
Monitoring of cytogenetic effects in tick-borne encephalitis patients with type 2 diabetes mellitus, depending on polymorphism of glutathione-S-transferase genes
Authors: Ilyinskikh Nikolay N. , Kostromeeva Marina S. , Ilyinskikh Ekaterina N.
Published: August 2019

BACKGROUND: Tick-borne encephalitis (TBE) is an acute viral disease with activation of oxidative stress and increasing in cytogenetic instability. Clinical symptoms of infectious diseases usually more severe in patients with type 2 diabetes mellitus (DM2), especially in the case of burden in the genotype of mutant variants of glutathione-S-transferase genes GSTM1 and GSTT1.
AIMS: The aim of this study was to study the dynamics of the frequency of micronucleated cells in patients with acute TBE with concomitant DM2, depending on the burden of active and inactive variants of glutathione-S-transferase genes (GSTM1 and GSTT1) in the patients genotype.
MATERIALS AND METHODS: Totally, samples to make micronucleus assay were obtained from 138 patients with febrile illness of acute TBE, 64 of whom were diagnosed with concomitant DM2 (groups 3 and 4). As control groups, 57 healthy individuals (control 1) and 61 patients with DM2 (control 2) were examined. The samples of buccal cells for the micronucleus assay were repeatedly obtained from the individuals on the first day of admission, and also after 1 week, 1, 3 and 6 months. Polymerase chain reaction was used to analyze the variants of the GSTM1 and GSTT1 genes.
RESULTS: On the first days of the disease, significant increases in the frequency of micronucleated buccal cells were determined in all TBE patients as compared to controls 1 and 2 (P0.001). Significant increases in the frequency of micronucleated buccal cells was revealed in groups 3 and 4 of the TBE patients who were carriers of inactive variants of the GSTM1(0) and GSTT1(0) genes, as compared to the subgroup of TBE patients with active variants of these genes (P0.001). In all subgroups of TBE patients with concomitant DM2, the frequencies of micronucleated cells were significantly higher than in the subgroups of TBE patients without DM2 (P0.001). Study of the dynamics of the frequency of micronucleated buccal cells, as compared to the control, demonstrated that the highest and long-lasting (within 6 months) cytogenetical effects were maintained in the group of TBE patients with genotype GSTM1(0)/GSTT1 (0) and concomitant DM2.
CONCLUSION: The most prolonged and highest increases in the frequencies of cytogenetically instable cells were determined in the group of acute TBE patients with concomitant DM2 who were carriers of the genotype with inactive variants of both GSTM1(0) and GSTT1(0) glutathione-S-transferase genes.
Mutations in transcription factor as rare causes of diabetes in pregnancy
Authors: Zubkova Natalia A. , Burumkulova Fatima F. , Petrukhin Vasily A. , Plechanova Margarita A. , Panov Anton E. , Vasilyev Evgeny V. , Petrov Vasily M. , Makretskaya Nina A. , Tyulpakov Anatoliy N.
Published: August 2019

MODY1 and MODY3 represent rare causes of diabetes in pregnancy. Establishing a molecular diagnosis of MODY1 or MODY3 during pregnancy may be important for minimizing risk of perinatal complications and for improving glycemic control after pregnancy. The objective of the study was to evaluate the contribution of mutations in HNF4A and HNF1A genes in development of diabetes in pregnancy and to describe clinical characteristics of diabetes in pregnancy associated with these mutations. 230 pregnant women (20-43 years) with different type of glucose intolerance complicated during their current pregnancy were included in the study. A custom NGS panel targeting 28 diabetes causative genes was used for sequencing. Heterozygous mutations in HNF4A and HNF1A genes were detected in 3% of cases. Mutations p.I271T in HNF4A gene and p.L148F, p.Y265C, p.G288W in HNF1A gene were novel. This study includes a description of patients with pregnancy diabetes due to mutations in hepatocyte nuclear factors.
An ovarian hyperstimulation syndrome caused by gonadotropinoma in a young woman
Authors: Gorbacheva Anna M. , Przhiyalkovskaya Elena G. , Azizyan Vilen N. , Stanoevich Irina V. , Grigoriev Andrey Yu. , Sazonova Anna I. , Lapshina Anastasiya M. , Belaya Zhanna E.
Published: August 2019

From 14 to 54% of all pituitary adenomas are nonfunctioning pituitary adenomas (NPAs), their prevalence is estimated as 7.041.3 cases per 100 000 population. The most common type of NPAs (73% of cases) are gonadotropinomas. In most cases, gonadotropinoma is characterized by secretion of biologically inactive hormones, so the release of gonadotropins does not lead to the development of any clinical symptoms. For this reason the diagnosis of gonadotropinomas is most often performed on the basis of immunohistochemical analysis. However, in rare cases, gonadotropinomas secrete biologically active hormones, most often follicle-stimulating (FSH). Ovarian hyperstimulation syndrome due to gonadotropin-secreting pituitary tumors occurs in about 3% of women with hormonally inactive pituitary adenomas at reproductive age and in 8% of patients with verified gonadotropinomas. This clinical case describes a young patient with a rare pathology: FSH/LH-secreting macroadenoma of the pituitary, which led to the development of ovary hyperstymulation symdrome. The diagnosis of pituitary adenoma was performed due to the identified hyperprolactinemia one month before the development of visual impairment, which can be considered a late diagnosis. Surgical treatment of gonadotropinomy was carried out successfully and without complications, remission of the disease was achieved, visual function was restored, the patient successfully became pregnant.
Possibilidades de abordagem dos poemas homéricos: arqueologia e linguística como “horizonte hermenêutico” das obras
Authors: Marques Gonçalves Ana Teresa , Miguel de Souza Marcelo
Published: August 2019

as possibilidades de abordagem dos poemas homéricos são muitas e variadas. Desde aquelas que dialogam com linhas mais tradicionais de teoria literária, passando por estudos históricos, arqueologia, linguística e também filologia. As descobertas arqueológicas, durante os últimos dois séculos, tiveram importante impacto na ampliação e na própria interpretação tanto da Ilíada quanto da Odisseia. consideradas até meados do século XiX como obras ficcionais, toda sua compreensão foi alterada após as descobertas de h. Schliemann e a. Evans. além disso, a tradução do linear B micênico e as possíveis analogias com os chamados anais dos hititas nos possibilitaram interessantes ligações. Este artigo objetiva problematizar algumas dessas linhas de análise, visando relacionar tais descobertas com a expansão de um “horizonte hermenêutico” das obras para o historiador.

Palavras-chave: homero; arqueologia; linguística.
A Farsália, de Lucano, como obra historiográfica
Authors: Ribeiro Leite Leni
Published: August 2019

Partindo das reflexões de Rao, Shulman e Subrahmanyam sobre a textura das narrativas históricas e do que aponta Vieira acerca dos princípios da épica romana como textos de caráter eminentemente historiográficos, procuramos neste artigo observar de que forma a Guerra civil de lucano se aproxima mais de uma narrativa historiográfica romana, a partir do que laird chama de “retórica da historiografia romana”, do que da epopeia vergiliana, tomada como exemplar. Para tanto, analisaremos trechos da obra de lucano em contraste com outras, como as de Plínio o Velho, Tito Lívio e Veleio Patérculo. com isso, pretendemos trazer um exemplo de como gêneros entendidos como eminentemente ficcionais, como a epopeia, podem ser considerados historiográficos em outras sociedades.

Palavras-chave: Farsália; lucano; épica histórica.
A poesia épica e a experiência trágica: o naufrágio de Sepúlveda
Authors: Do Amaral Felipe Cleber Vinicius
Published: August 2019

A experiência trágica seria incompatível com a glória heroica a ponto de constituir um empecilho ao canto épico? Uma matéria que destacasse a fragilidade da condição humana impediria o deleite, contrariaria os protocolos do gênero e/ou seria desdobramento de um contexto histórico pessimista? Em que medida a manifestação do heroísmo dependeria dos dramas da finitude? Com o presente artigo, pretende-se responder a essas questões tomando como objeto o Naufrágio de Sepúlveda (1594), poema atribuído a Jerônimo Corte-Real.

Palavras-chave: poesia épica; experiência trágica; Naufrágio de Sepúlveda.
Os conjuntos regionais e o som do choro: a caracterização da performance no acompanhamento do choro
Authors: Ferreira de Paula Pessoa Felipe
Published: August 2019

o trabalho tem por objetivo discutir o processo de formação do conjunto regional e como esse processo influenciou na formação de um modelo de performance no acompanhamento do choro. Propõe-se uma perspectiva histórica fundamentada nos fonogramas de choro desde o surgimento dos grupos e dos duos de violões, no início do século XX, à consolidação desse conjunto na década de 1930/1940, com o regional do Benedito lacerda. Uma das características principais da abordagem é o foco no modo de acompanhar dos duos de violão no contexto do conjunto regional, criando um modelo de performance que se formou e consolidou junto ao desenvolvimento do choro como uma prática musical inserida na então emergente indústria fonográfica. A principal fundamentação teórica para as análises das gravações foi o conceito de som, proposto por Delalande, que compreende como as mídias e a fonofixação permitem uma nova escuta do som, ampliando a concepção de timbre e da própria performance.

Palavras-chave: choro; conjunto regional; performance.
Anti-anti-iluminismo: a teoria da história segundo Estevão de Rezende Martins
Authors: Da Mata Sérgio
Published: August 2019

MartiNS, Estevão c. de rezende. Teoria e filosofia da história: contribuições para o ensino de história. curitiba: W. a. Editores, 2017, 331 p.
Dois novos Homeros em diálogo: as traduções de Werner e Vieira
Authors: Malta Campos André
Published: August 2019

...acho que, se o narrar uma história e o cantar um verso pudessem se reunir outra vez, uma coisa muito importante talvez acontecesse.
Pragmatic competence of heritage learners of Chinese and its relationship to social contact
Authors: Taguchi Naoko , Zhang Haomin , Li Qiong
Published: August 2019

This study aimed to investigate: (1) Chinese heritage learners’ (CHLs) pragmatic competence in comparison to foreign language learners of Chinese (CFLs) and (2) the relationship between CHLs’ pragmatic competence and their language contact in a range of social settings. Focal linguistic forms included sentence final particles (SFPs) and formulaic expressions (FORs). Sixty Chinese language learners in the intermediate- and advanced-level classes (31 CHLs and 29 CFLs) participated in the study. Participants completed a computerized listening comprehension task, a written production task, and a language contact questionnaire. Findings showed that CHLs outperformed CFLs in both comprehension and production of Chinese sentence final particles and formulaic expressions. The analysis of language contact questionnaire revealed that learners who reported a greater amount of interactive language contact achieved higher scores on the pragmatic tasks, regardless of the constructs and skill domains assessed.
“I’ll teach you differences.” A meta-theoretical approach to narrative theory
Authors: Greve Anniken
Published: August 2019

The article seeks to explore sameness and difference in narrative theory by way of shifting the emphasis from the narratives themselves to the research acts we perform on narratives. It proposes a model for analyzing research acts. Applying this model to various research acts in narrative theory it shows that what it implies to look for sameness and difference within narratives will vary with the kind of research act in question. Highlighting the difference between research acts that make theoretical claims about groups of narrative and research acts that seeks to explore the meaning of individual narratives, the article is critically geared both towards theories that stress the fiction/non-fiction divide and towards theories that seek to formulate a narrative theory that encompasses narratives of all kinds. It argues for the place in narrative theory of interpretive working procedures that allow us to focus on the individual narrative, in order to grasp its potential contribution to the human conversation.
Aromatherapy reduces fatigue among women with hypothyroidism: A randomized placebo-controlled clinical trial
Authors: Hawkins Jessie , Hires Christy Y. , Dunne Elizabeth W. , Keenan Lindsey A.
Published: August 2019

Background

This randomized, blinded, placebo-controlled clinical trial identifies the effect of an aromatherapy blend of essential oils on fatigue, which is one of the most commonly unaddressed symptoms of hypothyroidism, by evaluating the effects of daily aromatherapy inhalation.

Methods

Participants included women aged 18–55 with a diagnosis of hypothyroidism. Women who had a history of thyroid cancer were excluded, due to the confounding effects of cancer on fatigue as the outcome of interest. Participants were randomized into two groups: the aromatherapy group, treated with inhalation of the essential oil blend, and the control group, treated with an odorless vegetable oil blend. The primary outcome was change from baseline in fatigue scores as measured by the Multidimensional Fatigue Symptom Inventory (MFSI), a validated instrument which measures multiple patterns of fatigue.

Results

After adjusting for baseline scores, no significant difference was found between the aromatherapy group and the control group at midpoint. Both groups experienced a reduction in symptoms during the first week of the intervention. At the endpoint, participants in the aromatherapy group had improved fatigue scores across all ten subscales, as compared to the control group. Not all improvements achieved statistical significance, indicating that the aromatherapy treatment has a greater effect on the subscales of global, affective, and general fatigue.

Conclusions

This is the first study to evaluate the effects of aromatherapy on fatigue among women with hypothyroidism. These findings provide evidence that regular inhalation of an aromatherapy blend may reduce fatigue among women with hypothyroidism, particularly in the areas of global, affective, and general fatigue.
Talking proper vs. talking with an accent: the sociolinguistic divide in original and translated audiovisual dialogue
Authors: Ranzato Irene
Published: August 2019

The codification of propriety – talking with a ‘proper’ accent – is recorded in audiovisual texts so that cross-cultural interaction between social groups is not left to verbal dialogue alone but to more or less accurate visual cues and to paralinguistic as well as prosodic information. This chapter will examine scenes from various audiovisual texts, which feature characters speaking with a British received pronunciation – arguably, the ‘proper’ accent – in contrast to those who speak with a variety of British accents. The main purpose of these narratives is the portrayal of a sociolinguistic divide, either to provide a realistic account of problematic or potentially inflammatory culture clashes or as stereotypical means to elicit a humorous response. The problem of transferring information related to such a linguistic and social gap in audiovisual translation has long been recognised as one of the most difficult challenges translators have to deal with. The examples quoted in this article, all related to the dubbing mode of translation, will, however, illustrate how prosodic and suprasegmental features can travel cross-culturally and could be, and sometimes are, taken into account by translators and adapters to maintain the linguistic contrast observed in the originals.
A Change in the Distribution of Accents in Homer in Verses with Trochaic Words Ending in the Fourth Trochee
Authors: Abritta Alejandro
Published: August 2019

The goal of this paper is to present an accentual rule for a combination of locations of the Homeric hexameter, the fourth and the sixth metra. The author shows that, when there is a trochaic word ending in the fourth trochee, the location of Hermann’s bridge, there is a change in the distribution of accent types in the sixth metron, favoring what he calls “barytone falls”, that is, post-acute long syllables. After presenting the regular distribution of accents in the sixth metron, the author shows how that distribution is modified when there is a trochaic ending word in the fourth trochee. The results are later revised for possible formulaic interferences. Finally, he considers the implications of this phenomenon for the interpretation of Hermann’s law and speculates on its influence on current explanations of that rule.
The RESPECT method.
Simple proof of finding estimates from below for minimal singular eigenvalues of random matrices whose entries have zero means and bounded variances
Authors: Girko Vyacheslav L.
Published: August 2019

The lower bounds for the minimal singular eigenvalue of the matrix whose entries have zero means and bounded variances are obtained.
The new method is based on the G-method of perpendiculars and the RESPECT method.
Cytotoxic and anti-inflammatory resorcinol and alkylbenzoquinone derivatives from the leaves of Ardisia sieboldii
Authors: Shahinozzaman Md , Ishii Takahiro , Halim Mohammad A. , Hossain Md Amzad , Islam Md Tofazzal , Tawata Shinkichi
Published: August 2019

Medicinal plants belonging to the genus Ardisia are traditionally used to cure various human diseases including inflammation and cancer. This study aimed to purify and characterize cytotoxic and anti-inflammatory compounds from Ardisia sieboldii leaves. Bioassay-guided chromatographic analyses yielded three compounds, 2-methyl-5-(8Z-heptadecenyl) resorcinol (1), 5-(8Z-heptadecenyl) resorcinol (2), and ardisiaquinone A (3), whereas liquid chromatography–electrospray ionisation–mass spectrometry chemical profiling revealed the presence of diverse resorcinol and alkylbenzoquinone derivatives in cytotoxic 70% methanol extracts. Chemical structures of 1
–
3 were confirmed by spectroscopic methods including 1H NMR (nuclear magnetic resonance), 13C NMR, and electrospray ionisation–mass spectrometry. Compounds 1 and 2 were purified from A. sieboldii for the first time, and all three compounds showed cytotoxicity against a panel of cancer cell lines and brine shrimps in a dose-response manner. Among them, compound 2 exhibited the highest cytotoxicity on cancer cells (IC50 values of 8.8–25.7 μM) as well as on brine shrimps (IC50 value of 5.1 μM). Compounds 1
–
3 exhibited anti-inflammatory effects through inhibiting protein denaturation (IC50 values of 5.8–9.6 μM), cyclooxygenase-2 activity (IC50 values of 34.5–60.1 μM), and nitrite formation in RAW 264.7 cells. Cytotoxic and anti-inflammatory activities of 1
–
3 demonstrated in this study deserve further investigation for considering their suitability as candidates or leads to develop anticancer and anti-inflammatory drugs.
The Relevance of Positive Word-of-Mouth Effects on the Customer Lifetime Value - A Replication and Extension in the Context of Start-ups
Authors: Grossmann Manuel , Brock Christian , Hubert Marco , Reimer Thomas
Published: August 2019

This paper investigates the importance of positive word-of-mouth (WOM) effects on estimating the customer lifetime value (CLV) in start-up businesses. In line with prior research, we assume that, especially in young companies such as start-ups, managers and investors neglect the impact of WOM and therefore underestimate the CLV. To examine this assumption, self-collected WOM data is integrated into calculation of the CLV of a one-yearold online grocery retailer start-up. The CLV of 632 customers is combined with a survey about positive WOM activities. The study shows the high relevance of WOM for start-ups in a noncontractual as well as service setting, thereby calling for integration of WOM into calculation of the CLV.
Contamination of urbanized territories with eggs of helmiths of animals
Authors: Paliy A. , Sumakova N. , Petrov R. , Shkromada O. , Ulko L. , Palii A.
Published: August 2019

The large number of species which cause parasitic infestations and the wide variety of routes and factors of their transmission give great relevance to systematic veterinary-sanitary research into environmental objects, necessarily paying attention to local natural-climatic conditions, social structure and the activities of the population. This problem is most often studied by medical researchers and ecologists, and the extent of studies on this topic from a veterinary-sanitary point of view is insufficient, which conditioned our choice of the current scientific study. Our goal was determining the level of contamination of urbanized territories with exogenous forms of helminths. The research was conducted during 2010–2018 in the territory of Kharkiv Oblast of Ukraine. During the study, we examined 41 samples of soil, extracted both in rural areas, and in urban conditions, and also 100 samples of feces of animals and birds. During the examination of soil from rural areas in Kharkiv Oblast and soil in Kharkiv and Balakleia, we found that it was contaminated with eggs of helminths of different morphotypes. It was determined that mean level of contamination of soil in rural area equaled 12.5%. At the same time, the level of contamination of soil of river banks was 15% at intensity of 52 ± 5 eggs/kg of soil and 10.0% in meadows at intensity of 54 ± 8 eggs/kg of soil. The level of contamination of the soil of park zones of urbanized territories with exogenous stages of helminths was 5–55% and that of residential zones of cities was 20.0–23.3%. In general, in the samples of soil, eggs of Strongilata, Ascaridata, Trichocephalus and Cestoda were isolated, and in the soil of rural areas also eggs of Trematoda class. It was proved that cattle and small ruminants discharge feces into the environment which have highest number of eggs of Strongylata spp. helminths (285 ± 3 eggs/g of feces). Excrement of infested birds contaminate the environment with exogenous forms of helminths of Trichocephalata (Capillaria spp.) suborder (101 ± 7 eggs/g of feces). In cities, dogs and cats, infested with helminths, discharge into the environment feces with eggs of parasites that belong to Toxocara spp. (75 ± 4 eggs/g) and Dipylidium caninum (6 ± 1 eggs/g). Droppings of infested birds contaminate the environment with exogenous forms of helminthes of Strongylata spp. (57 ± 2 eggs/g), Аscaridia spp. (19 ± 4 eggs/g) and Capillaria spp. (11 ± 2 eggs/g).