bluuebunny/crossref_metadata_2025 huggingface dataset:
Andrographolide Reverses Doxorubicin Resistance in Human Breast Cancer Stem Cells by Regulating Apoptotic Gene Expressions
Authors: Wanandi Septelia Inawati , Syahrani Resda Akhra , Suraduhita Ayu , Yunita Elvira , Louisa Melva
Published: October 2023

BACKGROUND: Breast cancer stem cells (BCSCs) have been identified as playing a crucial role in therapeutic resistance. This resistance can be attributed to the anti-apoptotic protein survivin and the antioxidant MnSOD high expression. To overcome the resistance to doxorubicin (DOX), this study proposed the utilization of andrographolide (ANDRO), the primary bioactive compound in Andrographis paniculata leaves. The objective was to examine the role of andrographolide in regulating survivin, caspase-9, and caspase-3 gene expressions to reverse doxorubicin resistance in human BCSCs.METHODS: BCSCs were exposed to 0.1 µM DOX every two days or 50 µM rotenone (ROT) for 6 hours, subsequently supplemented with 0.3 mM ANDRO. Superoxide and peroxide levels were measured using DHE and DCFH-DA assay. The MnSOD, survivin, caspase-9, and caspase-3 mRNA expression levels were analyzed using qRT-PCR. Protein expressions were evaluated using Western blotting assay. MnSOD activity was determined using xanthine oxidase inhibition assay. The apoptotic cells were determined using Annexin-V/PI staining.RESULTS: This study indicated that the cytotoxic mechanisms of DOX, similar to ROT, in BCSCs were attributed to oxidative stress, as evidenced by an elevation in superoxide rather than peroxide levels, accompanied by a decrease in MnSOD activity. This study also highlighted that ANDRO reversed DOX resistance in BCSCs subjected to repeated DOX treatment by downregulating survivin and upregulating caspase-9 and caspase-3 mRNA expressions, thereby activating the intrinsic apoptotic pathway.CONCLUSION: This study provides insights into the role of ANDRO in modulating the expression of apoptotic genes, such as survivin, caspase-9, and caspase-3, to overcome DOX resistance in BCSCs.KEYWORDS: breast cancer, breast cancer stem cell, andrographolide, doxorubicin, oxidative stress, apoptosis
The Impacts of Vegetables and Fruits by Products on Growth and Health of Broiler Chickens
Authors: Readh CHAIB EDDOUR Ahmed , Miloud LITIM , Abdelkrim LARBAOUI , Chaïmaa BELHOCINE , Kaddour BOUDEROUA
Published: October 2023

Agro-industrial by-products, which are not intended for human consumption, can serve as substitutes for traditional animal feed ingredients in animal nutrition. This can result in the production of animal products without causing competition for land or exacerbating the food versus feed dilemma, ultimately promoting environmental and economic sustainability. Utilizing co-products as animal feed has the potential to reduce feeding costs while enhancing the productive parameters, quality, animal welfare and sustainability of animal products. Numerous studies have indicated that fruits and vegetables are considered as significant sources of bioactive compounds. The extensive process of industrialization leads to the creation of considerable amounts of by-products, giving rise to grave ecological concerns. Hence, such a scenario necessitates the formulation of innovative approaches for effectively utilizing the resultant wastes, ensuring the potential to fabricate novel products with enhanced value. The generated by-products, reveal similar or higher antioxidant activity. It is recognized that these secondary products comprise various bioactive substances and may have the ability to serve as nutraceuticals for poultry, promoting their health and overall wellness. This review aims to summarize the exploitation of fruit wastes, namely, apple, citrus, banana, mango, pineapple and grape as well as vegetable by-products which are derived from tomato and olive cultivation. These byproducts can be in supplementation or substitution format. Some of these byproducts presented the following results: The addition of 2% dried sweet orange pulp to the diet significantly increased feed intake and total weight gain in broilers and the inclusion of dried orange pulp in broiler diets was found to reduce serum triglycerides and cholesterol. Also, the including of 10% apple peel in the diet led to an increase in the weight of the gizzard and small intestine in chickens. Additionally, diets containing 5% and 10% apple peel waste resulted in higher levels of lipids and HDL (high-density lipoprotein) in the blood serum, while LDL (low-density lipoprotein) and malondialdehyde levels decreased. Moreover, the including of 10% banana peel in poultry feed led to improved feed efficiency, feed conversion and the quality of poultry eggs and meat. However, the inclusion of olive cake with phytase to broiler chickens’ diet presented an increase of growth parameters increased. The incorporation of 10% of OC with phytase also resulted a reduction in plasma cholesterol and triglycerides and an increase in plasma inorganic phosphorus.
The Valorization and Potential Applications of Orange Byproducts and Waste in Poultry Feeding: A Review
Authors: Readh CHAIB EDDOUR Ahmed , Miloud LITIM , Abdelkrim LARBAOUI , Chaïma BELHOCINE , Kaddour BOUDEROUA
Published: October 2023

Some chemicals have been utilized as a feed additive and growth stimulator to boost poultry performance in recent decades. Cereals have been one of the most extensively utilized feed in the rearing period of broiler chickens but due to their highly price it can present an economic consequence and some limitations of their use, alternatives such as orange byproducts have been recommended. In the second point there is a large utilization of growth stimulants during the rearing period of broilers, but due to the adverse consequences of antibiotic resistance and the limitations of their use, alternatives such as probiotics, prebiotics, plant essential oils, essences and by-products have been recommended. Orange waste can be found in abundance in some parts of the world. Aldehydes, esters, terpenes, alcohols, ketones, carotenoids, nobiletin, pectin and bioflavonoids such as hesperidin and naringenin are among the volatile substances found in orange waste. The practical applications of orange by-products and pomace in chicken feeding are presented in this review paper. This review presented the effects of orange waste and by-products on chicken performance and carcass components.
In Flight Preterm Birth is There a Doctor on Board?
Authors: Kren Aljaž
Published: October 2023

This case report a case of in-flight preterm birth. In-flight medical emergencies can occur when a passenger or crew member becomes ill or injured during a flight. Preterm birth, defined as birth before 37 completed weeks of gestation, is a significant public health concern worldwide due to its association with increased neonatal morbidity and mortality. Although in-flight medical emergencies and onboard deaths are uncommon, they pose a significant challenge to the airline industry. The medically austere environment, coupled with limitations on prudent practice and associated liabilities, requires physicians and other healthcare providers traveling on flights to be aware of these factors.
Da estética do tempo mínimo à poética da pandemia máxima
Authors: Martins José Endoença
Published: October 2023

O ensaio discute as relações entre a produção poética e a experiência pandêmica. Estabelece o movimento identitário do narrador poético entre três modalidades de produção poética. Trata-se de triangulação artística que se envidencia entre Poema Minuto, Diet Poesia e Minimalismus Pandemicus.  Para a caracterização do deslocamento intervérsico a tríplice produção artística, vale-se dos conceitos de “celebração móvel” de Hall (2006), das noções de dupla vocalidade da Signifyin(g) e da tripla dimensão de Exu e Iorubás, segundo Gates (1988), além da ideia de política da conversão de West (1994). O ensaio sugere recorrer a uma ética do amor que, segundo West, teria a capacidade de estabelecer uma epistemologia poética com vistas a proteger a terra e fazer um mundo melhor.
mt-tRNAs in the polymerase gamma mutant heart
Authors: Bayazit M. Bilal , Francois Ashley , McGrail Erin , Accornero Federica , Stratton Matthew S.
Published: October 2023

Introduction: Mice harboring a D257A mutation in the proofreading domain of the mitochondrial DNA polymerase, Polymerase Gamma (POLG), experience severe metabolic dysfunction and display hallmarks of accelerated aging. We previously reported a mitochondrial unfolded protein response (UPTmt) - like (UPRmt-like) gene and protein expression pattern in the right ventricular tissue of POLG mutant mice.

Aim: We sought to determine if POLG mutation altered the expression of genes encoded by the mitochondria in a way that might also reduce proteotoxic stress.

Methods and Results: The expression of genes encoded by the mitochondrial DNA was interrogated via RNA-seq and northern blot analysis. A striking, location-dependent effect was seen in the expression of mitochondrial-encoded tRNAs in the POLG mutant as assayed by RNA-seq. These expression changes were negatively correlated with the tRNA partner amino acid’s amyloidogenic potential. Direct measurement by northern blot was conducted on candidate mt-tRNAs identified from the RNA-seq. This analysis confirmed reduced expression of MT-TY in the POLG mutant but failed to show increased expression of MT-TP, which was dramatically increased in the RNA-seq data.

Conclusion: We conclude that reduced expression of amyloid-associated mt-tRNAs is another indication of adaptive response to severe mitochondrial dysfunction in the POLG mutant. Incongruence between RNA-seq and northern blot measurement of MT-TP expression points towards the existence of mt-tRNA post-transcriptional modification regulation in the POLG mutant that alters either polyA capture or cDNA synthesis in RNA-seq library generation. Together, these data suggest that 1) evolution has distributed mt-tRNAs across the circular mitochondrial genome to allow chromosomal location-dependent mt-tRNA regulation (either by expression or PTM) and 2) this regulation is cognizant of the tRNA partner amino acid’s amyloidogenic properties.
Einstein’s Dream: Realization and Failure
Authors: Pandey S K
Published: October 2023

Several mathematicians and physicists are working all over the globe to get a unified theory. However, most of them are discarding Einstein’s view at the very first step of their theories. This article provides a brief description about this. Also, on the basis of Koga’s theory we point out two reasons which might have caused Einstein’s failure to get a unified theory.
Colorectal Cancer Stem Cells and Targeted Agents
Authors: Zhao Haobin , Han Ruining , Wang Zhankun , Xian Junfang , Bai Xiaosu
Published: October 2023

Once discovered, cancer stem cells have become a hot topic in the research of cancer therapy. These cells possess stem cell-like self-renewal and differentiation capacities and are important factors that dominate cancer metastasis, therapy- resistance and recurrence. What's worse, their own characteristics make them difficult to be eliminated. Colorectal cancer is the third most common cancer and the second leading cause of cancer death worldwide. Targeting colorectal cancer stem cells (CRCSCs) can inhibit colorectal cancer metastasis, enhance therapeutic efficacy, and reduce recurrence. Here, we introduced the origin, marker proteins, identification, cultivation and research techniques of CRCSCs, summarized the signaling pathways that regulate the stemness of CRCSCs, such as Wnt, JAK/STAT3, Notch, and Hh signaling pathway. In addition to these, we also reviewed anti-CRCSC drugs targeting signaling pathways，markers，and other regulators in recent years. These will help researchers gain insight into the current agents targeting to CRCSCs, explore new cancer drugs, and propose potential therapy.
Recent Advances in Reverse Water Gas Conversion Reaction
Authors: Zhou Changjian , Zhang Jiahao , Fu Yuqing , Dai Hui
Published: October 2023

The increase in carbon dioxide emissions has a significant impact on human society and the global environment. As the most abundant and cheap C1 resource, the conversion and utilization of carbon dioxide has received extensive attention from researchers. In many methods of carbon dioxide conversion and utilization, the reverse water gas conversion reaction is considered to be one of the most effective ways. In this paper, the research progress of reverse water gas conversion reaction in recent years is introduced.
Portuguese Validation of a Reduced Version of the IAT (Internet Addiction Test) Scale—Youth Version
Authors: Patrão Ivone , Borges Inês , Sobral Patrícia , Moreira Ana
Published: October 2023

This study adapted and assessed a shortened version of the IAT (Internet Addiction Test) scale completed by young people aged 12 years and older regarding their online behaviors and risk of online addiction. The psychometric qualities of the reduced version - Screening IAT - youth are presented in order to validate its use in the early detection of online addiction. The total sample is composed of 3021 participants being 55.9% female and 44.1% male, with a mean age of x ̅=15 years (σ=3.028), attending junior high school (56.2%), high school (37.8%) and college (5.9%). The procedure included a factorial analysis, in which the total sample was randomly divided into three samples. An exploratory factor analysis was performed with one part of the sample, and a confirmatory factor analysis was performed with the others parts, assessing internal consistency, construct reliability, and discriminant validity. The results indicate that this reduced version of the IAT for young people has good psychometric qualities and can be applied in research and clinical settings. With this version and the parent-teacher version there is a direct contribution to a tripartite assessment of internet addiction risk.
Management of Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP) - A Case Report
Authors: Drača Natasha , Orešković Emma Grace , Lazić Ratimir , Vukojević Marija , Radolović Bertetić Andrea , Vukojević Nenad
Published: October 2023

Background and Objectives: A 62-year-old patient presented with significant visual reduction in the last three months. Best corrected visual acuity (BCVA) of the right eye (RE) dropped from 20/20 on both eyes to 20/200 on the RE and counting fingers (CF) on the left eye (LE); respectfully. She was diagnosed with stage 4 ovarian cancer 1 month ago. Materials and Methods: Examination revealed significant progression of cataracts and subretinal fluid on the posterior pole with choroidal thickening. Multifocal, orange-pigmented elevated choroidal lesions were observed in the RE, while the view of the left eye fundus was obstructed by cataracts. OCT revealed bilateral choroidal thickening with overlying folds and subretinal fluid and ultrasound of the choroidal lesions showed moderate homogenous internal reflectivity. Results: The patient was diagnosed with BDUMP (bilateral diffuse uveal melanocytic proliferation), a paraneoplastic syndrome characterised by simultaneous, bilateral, painless vision loss and rapidly acquired bilateral cataracts with serous retinal detachments. Cataract extraction had not obtained the expected visual recovery (RE: CF; LE 2/200, respectfully). Plasmapheresis demonstrated some success by stabilizing vision loss obtained by serous retinal detachments. Conclusion: The focus of treating BDUMP is aimed at the underlying malignancy. Vision typically deteriorates to near blindness within a year from presentation. Overall prognosis is generally poor and mean survival is reported at 12-15.7 months from the time of ocular diagnosis.
İLKOKUL ÖĞRENCİLERİNİN P4C DESTEKLİ MATEMATİKSEL MODELLEME UYGULAMALARI: BİR ÖĞRETİM DENEYİ
Authors: KAYGISIZ Dr.ismail
Published: October 2023

Tarihi Sokrates’e kadar uzanan Çocuklar için felsefe (P4C), çocukların düşünme yeteneklerini geliştiren eğitimsel bir uygulamadır. P4C etkinliklerinde çocuklar düzeylerine uygun felsefi kavramları metinler ve faklı uyarıcılar eşliğinde tartışırlar. Günümüz görsel çağında bu uyarıcılardan biri de çocukların farklı duyularına hitap eden çizgi filmlerin olduğu düşünülmektedir. Matematiksel modelleme gerçek yaşam problemlerinin matematik dünyasına taşınarak, matematiksel yöntemlerle çözülüp yorumlanmasını ve doğrulanmasını içeren döngüsel bir süreçtir. Günlük yaşam durumlarına eleştirel ve yaratıcı gözle bakabilen öğrencilerin matematiksel modelleme etkinliklerinde farklı çözüm önerileri getireceği düşünülmektedir. Bu araştırmanın amacı P4C etkinliklerine katılan öğrencilerin matematiksel modelleme uygulamalarındaki çözüm sürecini incelemektir. Araştırmada öğretim deneyi yöntemi benimsenmiştir. Veri kaynağı olarak P4C etkinliklerinde TRT Çocuk kanalında yayınlanan Akıllı Tavşan Momo Biz Bir Takımız ve Rafadan Tayfa Servis, matematiksel modelleme etkinliklerinde ise araştırmacı tarafından hazırlanan Kim Koşsun ve Piknik etkinleri kullanılmıştır. Çizgi filmlerdeki diyaloglar içerik analizi ile incelenip felsefi kavramlarla ilişkilendirilmiştir. İncelenen çizgi filmlerde başarı, iyilik-kötülük, güven, doğruluk, sorumluluk, adalet-adaletsizlik, sevgi-saygı, güven gibi pek çok felsefi kavrama ulaşılmıştır. P4C etkinlikleri izleme, izleme-soru oluşturma, soru oluşturma-tartışma ve tartışma-grup değerlendirmesi olarak dört aşamada gerçekleştirilmiştir. P4C etkinlikleri uygulanırken öğrencilere yöneltilen sorular yaratıcı ve eleştirel düşünme becerilerini ortaya çıkarmaya yönelik SCAMPER tekniği kullanılarak gerçekleştirilmiştir. P4C etkinliği uygulanan ve uygulanmayan sınıflara ayrı ayrı matematiksel modelleme etkinlikleri uygulanmıştır. Araştırma sonucunda P4C etkinlikleri uygulanan öğrencilerin matematiksel modelleme süreçlerinin yorumlama ve değerlendirme basamaklarında daha farklı düşünme becerileri sergiledikleri gözlemlenmiştir.
Öğretmenlerin Çocuklar İçin Felsefe Uygulamalarına İlişkin Görüşleri: Sorunlar ve Çözümler
Authors: AKKOCAOĞLU ÇAYIR Nihan
Published: October 2023

Düşünme becerileri başta olmak üzere çocuklara pek çok katkı sağlayan çocuklar için felsefenin (ÇİF) elli yılı geride bıraktığı göz önüne alındığında yeterince yaygınlaşamadığı söylenebilir. Bunların sebeplerini tespit etmek için ÇİF’i sınıflarında kullanan öğretmenlerin görüşlerini almak önemlidir. Bu araştırmada öğretmenlerin, çocuklarla felsefe yapma süreçlerinde yaşadıkları sorunları, sorunların kaynaklarını ve bu sorunlara ilişkin çözüm önerilerini tespit etmek amaçlanmıştır. Öğretmenlerin deneyimlerine odaklanan bu çalışmada nitel araştırma desenlerinden fenomenoloji kullanılmıştır. Sınıflarında felsefe yapan 75 öğretmene çocuklarla felsefe yapma süreçlerinde yaşadıkları sorunlar ve bunlara ilişkin önerileri sorulmuştur. Katılımcılar arasından beş öğretmenle bireysel yarı yapılandırılmış görüşmeler gerçekleştirilmiştir. Katılımcıların görüşleri doğrultusunda öğretmenlerle, çocuklarla, ÇİF’e yönelik bakış açılarıyla, olanaklarla, ders ve okul programlarıyla ilişkili olmak üzere 5 temel sorun alanı belirlenmiştir. Öğretmenler, özellikle tartışmayı derinleştirmede, soru sormakta ve tarafsız olmakta güçlük çekmektedirler. Öğretmenlere göre çocuklar ise en çok tartışmaya odaklanmakta, derin düşünmekte ve birbirlerini dinlemekte zorlanmaktadırlar. Öğretmenler ÇİF’in yeterince tanınmamasını ve önemsenmemesini de sorun olarak görmektedirler. Ayrıca sınıfların kalabalığı ve ÇİF’e okullarda yeterli süre ayrılmaması da problemler arasındadır. Katılımcılara göre bu sorunların kaynakları ise daha çok geleneksel eğitim sistemine dayanmaktadır. Çocukların gelişimsel özellikleri, öğretmenlerin yetersiz deneyimleri, etkili olmayan ÇİF öğretmen eğitimleri ve felsefeye yönelik olumsuz algılar da bu kaynaklardandır. Katılımcılar, öğretmenlere, velilere ve okul yönetimine, MEB ve üniversitelere, ÇİF öğretmen eğitimlerinin içeriğine ve çocuk edebiyatı alanına yönelik öneriler de sunmuşlardır. Çocuklarla felsefenin doğru anlaşılması ve yaygınlaşması için öğretmenlerin sorunlarına odaklanan eylem araştırmaları düzenlenebilir. Bu sorunların çözümüne yönelik nitelikli hizmet içi eğitimler verilmesi, ÇİF’in bir ders olması gibi tüm paydaşları içeren bir yaklaşıma ihtiyaç duyulduğu söylenebilir.
Marriage is Shackle: Alcott’s Sobered and Muddled View of Women in Little Women
Authors: Minghui Qiu
Published: October 2023

Little Women is a classic work of literature that has captivated readers for generations. It tells the story of four sisters who grow up during the Civil War era in America and explores their struggles with poverty, societal expectations, and their own personal desires. While the book is celebrated for its portrayal of strong female characters and their self-awareness, it also highlights the limitations and one-sidedness of women’s consciousness awakening, particularly with regard to the view of marriage. Alcott’s progressive female thoughts are evident, as she portrays women who are determined to carve out their own paths and not be solely defined by their marital status. However, at the same time, there is an underlying sentiment of traditional gender roles and the idealization of marriage, which limits the full expression of a woman’s agency. This dependence on men is further reinforced by the societal norms and beliefs surrounding marriage during that time, such as portraying it as the ultimate goal of a woman’s life.
Exploring Pedagogical Inadequacies in Current Teaching Practices in ESL Classroom at College Level: The Students’ perspective
Authors: Malik Amir Hafeez , Ramzan Fozia , Parveen Shahida , Rashid Abdul
Published: October 2023

English language teaching and learning remain the focus of the academic system as English is a compulsory subject for all learners at college level. The success and smoothness of English language pedagogy depends largely on the active role of ELT teachers simply because of their dominant role inside classrooms. This paper presents a comprehensive view of pedagogical inadequacies in ESL classrooms at the college level in Punjab, Pakistan. This study is quantitative and the data has been collected through a survey questionnaire. The questionnaire was distributed to 250 students of public and private colleges of district Multan. Out of 250 students, 220 students responded questionnaire. The findings of the study proved that we are practicing inadequate pedagogical methods which are the root cause of learners’ dissatisfaction and poor quality of education. Quality teaching always remains a dream without enriching the teaching skills of the teachers that is only possible by removing the inadequacies in pedagogy. A revision of our pedagogical practices is suggested in the light of the analyzed data and drawn conclusion of the present study.
Avaliação da homogeneidade de pilares de concreto armado através da tomografia ultrassônica
Authors:   aboratório de Ensaios e Modelos Estruturais, Escola de Engenharia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil., Reginato L. A. , Lorenzi a. ,   aboratório de Ensaios e Modelos Estruturais, Escola de Engenharia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil., Lorenzi L. S. ,   Laboratório de Ensaios e Modelos Estruturais, Escola de Engenharia, Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Engenharia Civil: Construção e Infraestrutura, Porto Alegre, Brasil., Forsthofer R. ,   aboratório de Ensaios e Modelos Estruturais, Escola de Engenharia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil., Oliveira L. C. ,   aboratório de Ensaios e Modelos Estruturais, Escola de Engenharia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil., Ottoni T. P. ,   aboratório de Ensaios e Modelos Estruturais, Escola de Engenharia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil., Tirado L. H. B. ,   aboratório de Ensaios e Modelos Estruturais, Escola de Engenharia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Published: October 2023

A avaliação da homogeneidade de diferentes tipos de estruturas através da tomografia ultrassônica tem sido foco de pesquisadores no Brasil. Por conta disso, o objetivo desta pesquisa foi avaliar a homogeneidade da estrutura de pilares de concreto armado utilizando o equipamento da marca PROCEQ®, modelo PUNDIT PL-200PE. O ensaio de tomografia ultrassônica foi realizado em uma das faces de pilares com diferentes características, utilizando um grid de 15 cm (horizontal) x 10 cm (vertical). As leituras foram realizadas no pilar a partir do fundo da laje. Após a análise dos resultados, foi possível identificar regiões com prováveis defeitos ou com possíveis falhas em mais de 70% das amostras avaliadas.
Impacto en la resistencia a la compresión y durabilidad del concreto a partir de la sustitución de agregado fino pétreo por ecoarena de escoria de acero
Authors:   Área Académica de Ingeniería y Arquitectura, Universidad Autónoma del Estado de Hidalgo, Pachuca, México., Reséndiz-Reyes O. , López-León L. D. ,   Área Académica de Ingeniería y Arquitectura, Universidad Autónoma del Estado de Hidalgo, Pachuca, México., Olguin-Coca F. J. ,   Área Académica de Ingeniería y Arquitectura, Universidad Autónoma del Estado de Hidalgo, Pachuca, México., Castañeda-Robles I. E. ,   Área Académica de Ingeniería y Arquitectura, Universidad Autónoma del Estado de Hidalgo, Pachuca, México.
Published: October 2023

La industria cementera como la extracción de los agregados pétreos de canteras y ríos, causan gran contaminación en el medioambiente, sobre todo cuando se requieren materiales de máxima calidad para la elaboración del material más indispensable en la construcción, el concreto, a consecuencia de ello también se fabrican y comercializan diferentes productos que ayudan al aumento de las propiedades mecánica del concreto, sin embargo no resuelven el desgastamiento de los recursos naturales y las emisiones de CO2 causada por la fabricación del cemento, por lo que se busca una manera de reducir el uso de uno de los materiales pétreos que se usa en mayor cantidad, el agregado fino, utilizado tanto para concretos como en morteros. Sin descuidar los requerimientos mínimos de calidad y resistencia, como medida también para la reducción de desperdicios industriales, se busca reutilizarlos como agregados y sustituto parcial de la arena. El siguiente trabajo experimenta el uso de la escoria de acero, residuo de la maquila de acero, como agregado fino en proporciones de su volumen de 5% y 10%, evaluando sus propiedades de resistencia a la compresión, pesos volumétricos y pruebas de carbonación. Teniendo los mejores resultados de resistencia a la compresión y de baja carbonatación para el diseño con el porcentaje del 10 % de uso de escoria de fundición.
Primeras experiencias de uso de agregados reciclados para producir hormigones estructurales en Uruguay
Authors:   Instituto de Estructuras y Transporte, Facultad de Ingeniería, Universidad de la República, Montevideo, Uruguay., Vila P. , Bonjour H. ,   Instituto de Estructuras y Transporte, Facultad de Ingeniería, Universidad de la República, Montevideo, Uruguay., Pereyra M.N. ,   Instituto de Estructuras y Transporte, Facultad de Ingeniería, Universidad de la República, Montevideo, Uruguay.
Published: October 2023

El objetivo fue evaluar las propiedades de agregados reciclados producidos en Uruguay provenientes de trituración de hormigón de descarte y analizar el comportamiento de nuevos hormigones empleando este agregado. Se evaluaron propiedades físicas del agregado, se dosificaron y fabricaron cinco pastones, determinándose sus propiedades en estado fresco y endurecido. Los agregados reciclados presentaron densidad menor, absorción mayor, coeficiente de forma intermedio y desgaste mayor que agregados naturales, comportamiento asociado al contenido de mortero en los agregados reciclados. En hormigón la exudación aumentó, la resistencia también, el módulo de elasticidad fue similar y la succión capilar varió dependido del agregado y de su proporción de uso. Solo fueron evaluados dos agregados reciclados y un único nivel de resistencia.
Desempenho de hidrofugante de superfície na mitigação do ataque externo por sulfatos
Authors:   Departamento de Ingeniería Civil, Universidad Estatal de Ponta Grossa, Ponta Grossa, Brasil., Brekailo F. , Juncos R. F. O. ,   Departamento de Ingeniería Civil, Universidad Estatal de Ponta Grossa, Ponta Grossa, Brasil., Pereira E. ,   Departamento de Ingeniería Civil, Universidad Estatal de Ponta Grossa, Ponta Grossa, Brasil.
Published: October 2023

Esta pesquisa avaliou o uso de hidrofugante como impermeabilizante de superfície de amostras de concreto expostas a situações de ataque por sulfatos. As variáveis adotadas foram dois fatores água/cimento (0,43 e 0,53), além de dois tipos de sulfato (sulfato de sódio e de magnésio). Realizou-se ensaio acelerado de migração iônica, verificando o fluxo de íons sulfato ao longo do tempo, e finalizado o teste, a microestrutura das amostras foi avaliada. Os resultados obtidos indicam que a metodologia adotada foi eficiente e que o uso de hidrofugante tem capacidade de reduzir a passagem de íons. Apesar deste resultado, mesmo com o uso do protetor de superfície, foi verificada a ocorrência de ataque externo por sulfato.
Inspeção predial com auxílio de drone e com alpinismo industrial para identificação de desplacamento cerâmico em fachadas: um estudo de caso
Authors:   Programa de Pós-graduação em Engenharia Civil, Escola Politécnica de Pernambuco, Universidade de Pernambuco, Recife, Brasil., Costa L. V. B. , Teixeira B. C. ,   Programa de Pós-graduação em Engenharia Civil, Escola Politécnica de Pernambuco, Universidade de Pernambuco, Recife, Brasil., Cruz F. M. ,   Programa de Pós-graduação em Engenharia Civil, Escola Politécnica de Pernambuco, Universidade de Pernambuco, Recife, Brasil., Monteiro E. C. B. ,   Departamento de Engenharia civil, Universidade Católica de Pernambuco, Recife, Brasil., Soares W. A. ,   Programa de Pós-graduação em Engenharia Civil, Escola Politécnica de Pernambuco, Universidade de Pernambuco, Recife, Brasil.
Published: October 2023

O desprendimento de fragmentos das fachadas representa risco de acidentes fatais e métodos para a identificação desse problema são utilizados para a prevenção de danos. O objetivo deste artigo é analisar o resultado obtido na inspeção das fachadas de um estudo de caso quanto ao desplacamento cerâmico. A metodologia contemplou dois métodos: câmera acoplada a drone e alpinismo industrial. Nos resultados, foi realizada uma análise comparativa entre os fatores de mão de obra, custo, tempo de serviço, quantitativo de placas, limitações e riscos da operação. Como principal contribuição, foi constatado que a inspeção exclusivamente através de drone não é capaz de identificar todos os pontos com desplacamento cerâmico e que a inspeção tátil é crucial para percepção dessa manifestação patológica.
Resistencia de impacto aplicando el método Charpy en morteros reforzado con fibras naturales y sintética
Authors:   Centro de Investigación en Ingeniería y Ciencias Aplicadas, (CIICAp) Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México., Flores-Nicolás A. , Flores-Nicolás M. ,   Instituto de Ingeniería, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México., Menchaca-Campos E. C. ,   Centro de Investigación en Ingeniería y Ciencias Aplicadas, (CIICAp) Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México., Rosales-Cadena I. ,   Centro de Investigación en Ingeniería y Ciencias Aplicadas, (CIICAp) Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México., Uruchurtu-Chavarín J. ,   Centro de Investigación en Ingeniería y Ciencias Aplicadas, (CIICAp) Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
Published: October 2023

En este trabajo de investigación, tiene como propósito el estudio de las propiedades mecánicas de impacto en compuestos cementosos incorporando 0.2% de fibras naturales (mango y palma) y sintéticas en sustitución al peso del agregado fino. Se analizó detalladamente las dimensiones (largo, ancho y alto) y muesca de las probetas para el ensayo Charpy. Los resultados obtenidos revelaron que las fibras naturales de mango aumentaron ligeramente 2% la tenacidad y resistencia de impacto del material en comparación a la muestra control, los compuestos cementosos son materiales frágiles cuando están sometidos a esfuerzos de impacto. Así mismo, es importante conocer los detalles de las dimensiones de las probetas en el ensayo Charpy principalmente la profundidad de la muesca.
Coupled channel–floodplain dynamics and resulting stratigraphic architecture viewed through a mass-balance lens
Authors: Straub Kyle M. , Dutt Ripul , Duller Robert A.
Published: October 2023

Basin-wide accommodation production and associated sediment mass deposition exert fundamental controls on stratigraphic architecture, but the details of this relationship are not fully understood. This is because it is unknown how accommodation production directly influences morphodynamics both in terms of channel process (i.e., channel migration, channel avulsion) and floodplain process, both of which are themselves coupled dynamically and are critical to the nature of stratigraphic architecture. To address this, we expand on existing theory that links sediment mass balance and resultant stratigraphic architecture. We use two fan-delta experiments that each experience different rates of accommodation production to measure key surface morphometrics and subsurface sedimentary characteristics. Importantly, sediment was transported in bedload and suspension in these experiments, resulting in construction of strata characterized by channel bodies surrounded by overbank strata deposited from suspension fallout. From these data we use three key timescales to capture the overall behavior of the system when placed into mass-balance space: avulsion setup timescales (TA) and channel mobility timescales (TV) that define short-term surface autogenics, and an accretion timescale (TC) that incorporates longer-term deposition. We find that the ratio of both TC/TA and TC/TV are independent of accommodation production rate in mass-balance space, which supports a self-organized response of channel dynamics to environmental boundary conditions. The fraction of strata generated from key depositional environments largely supports this behavior, particularly for channel sand bodies that resulted in deposition from bedload transport. As such, our results suggest that channel-body density is independent of accommodation production rate in a mass-balance space. We found that, although contributing to a significant fraction of the basin strata, far-field overbank deposition rates are insensitive to accommodation production and that differences in autogenic timescales between experiments largely resulted from differences in channel deposition rates, highlighting the close coupling between channel dynamics and accommodation generation. More generally the observed self-organized response of surface morphodynamics to accommodation production in mass-balance space provides a process-based framework to explain the utility of balancing mass for the prediction of down-system sediment size fractionation and sedimentary architecture.
Mensajes persuasivos en redes sociales de la industria de alimentos y bebidas no saludables
Authors: García Abad , Valero-Morales Isabel , Valbuena-Gregorio Edith , Olivas-Aguirre Francisco Javier , Tolentino-Mayo Lizbeth , Barquera Simón , Nieto Claudia
Published: October 2023

Objetivo. Identificar los mensajes persuasivos usados por la industria de alimentos y bebidas no saludables en las redes sociales más visitadas por niñas, niños y adolescentes mexicanos y determinar a qué grupo de edad estaban dirigidos. Material y métodos. Se analizaron 892 anuncios de los 20 productos y marcas de alimentos y bebidas no saludables más consumidas en México publicados en las cuentas oficiales de dichos productos y marcas en YouTube, Facebook e Instagram. Se determinó el mensaje primario y el público objetivo (niños, adolescentes o ambos) y se clasificó como emocional o racional. Resultados. En Facebook, la proporción de anuncios con mensajes emocionales (50.7%) y mensajes racionales (49.3%) fue similar. En YouTube hubo mayor proporción de mensajes racionales (60.2%). Se encontraron 2.9 más posibilidades de que un mensaje persuasivo emocional se dirija a niños o adolescentes en comparación con mensajes que no tienen publicidad dirigida. Conclusión. La naturaleza de los mensajes persuasivos analizados depende de la red social en la que se presentaron. La industria alimentaria dirige sus mensajes a niños o adolescentes, razón por la que es importante regular la publicidad de alimentos y bebidas no saludables en redes sociales que busca influir en el comportamiento y las decisiones de compra de niñas, niños y adolescentes.
Encuesta Nacional de Salud y Nutrición Continua 2022: recomendaciones de política pública
Authors: Lazcano-Ponce Eduardo C , Shamah-Levy Teresa
Published: October 2023

El 21 de julio de 2023, en un seminario interno de los Institutos Nacionales de Salud y Hospitales de Alta Especialidad, se presentaron los resultados de la Encuesta Nacional de Salud y Nutrición Continua 2022 (Ensanut Continua 2022). Junto con expertos del más alto nivel, se plantearon recomendaciones con el fin de apoyar la salud de la población mexicana. Dichas recomendaciones giran en torno a las temáticas incluidas en la Ensanut Continua 2022, como vacunación, salud de niños y adolescentes, salud mental y dificultades de funcionamiento y estado de nutrición y enfermedades crónicas en adultos, entre otras. Los logros de este esfuerzo realizado para obtener información de manera continua son cruciales para saber cómo hacer frente a los factores que afectan a nuestra salud y poder tomar mejores decisiones de política pública en esta materia, bajo la premisa de que los problemas públicos requieren ser medidos y monitoreados permanentemente.
Promotion of an Antitumor Immune Program by a Tumor Specific Complement Activating Autoantibody
Authors: Saxena Ruchi , Bushey Ryan T. , Campa Michael J. , Gottlin Elizabeth B. , Guo Jian , Patz Edward F. , He You-Wen
Published: October 2023

Tumor targeting antibodies can be used to initiate an antitumor immune program, which appears essential to achieve a long-term durable clinical response to cancer. We previously identified an anti-complement factor H (CFH) autoantibody associated with early-stage non-small cell lung cancer (NSCLC) patients, and from their peripheral B cells cloned a monoclonal antibody, GT103, that specifically recognizes CFH on tumor cells. GT103 targets a conformationally distinct tumor epitope, kills tumor cells in vitro, and has potent antitumor activity in vivo, although the underlying mechanisms are not well defined. In the effort to better understand how autoantibodies can effectively promote an antitumor immune response, we found that GT103 activates complement and enhances antitumor immunity through multiple pathways. It creates a favorable tumor microenvironment (TME) by decreasing immunosuppressive regulatory T cells and myeloid-derived suppressor cells, enhances antigen-specific effector T cells, and has a synergistic antitumor effect with anti-PD-L1 mAb. Furthermore, the immune landscape of tumors from early-stage patients expressing the anti-CFH autoantibody is associated with an immunologically active TME. More broadly, our results using an autoantibody provides novel mechanistic insights into how a tumor specific, complement activating antibody can generate an immune program to kill tumor cells and inhibit tumor growth.
An empirical analysis of Sacha inchi (Plantae: Plukenetia volubilis L) seed proteins and their applications in food and biopharmaceutical industries
Authors: Rashid Mohammad Harun Ur , Amin Nor Datiakma Mat , Yi Erica Kok Jia , Ismail Mohd Nazri
Published: October 2023

Sacha Inchi (Plukenetia volubilis L) is a plant native to the Amazon rainforest in South America known for its edible seeds, which are rich in lipids, proteins, vitamin E, polyphenols, minerals, and amino acids. Rural communities in developing nations have been using this plant for its health benefits, including as a topical cream for rejuvenating and revitalising skin and as a treatment for muscle pain and rheumatism. Although sacha inchi oil has been applied topically to soften skin, treat skin diseases, and heal wounds, its protein-rich seeds have not yet received proper attention for extensive investigation. Proteins in sacha inchi seeds are generally known to have antioxidant and antifungal activities and are extensively used nowadays in making protein-rich food alternatives worldwide. Notably, large-scale use of seed proteins has begun in nanoparticle and biofusion technologies related to the human health-benefitting sector. To extract and identify their proteins, the current study examined sacha inchi seeds collected from the Malaysian state of Kedah. Our analysis revealed a protein concentration of 73.8 ± 0.002 mg/g of freeze-dried seed flour. Employing liquid chromatography-tandem mass spectrometry (LC-MS/MS) and PEAKS studio analysis, we identified 217 proteins in the seed extract, including 152 with known proteins and 65 unknown proteins. This study marks a significant step towards comprehensively investigating the protein composition of sacha inchi seeds and elucidating their potential applications in the food and biopharmaceutical sectors. Our discoveries not only enhance our knowledge of Sacha inchi's nutritional characteristics but also pave the way for prospective research and innovative advancements in the realms of functional food and health-related domains.
Assessment of sharpening profile effects on the efficiency of cutting tools for tire recycling: a numerical study
Authors: Teran Leonel Alveyro , Cárdenas Leydi Julieta , Ruiz Luis Fernando , Hincapié Duberney
Published: October 2023

Recycling end-of-life tires (ELTs) poses an enormous challenge in waste management, as tires are not biodegradable and, if not correctly disposed of, can cause problems for human health and the environment. The transportation of ELTs from waste collection points to recycling facilities is one of the biggest problems in the recycling process, as a whole piece of ELT takes a large volume, resulting in high costs and transport delays. Therefore, a possible solution is a pre-cutting process at collection points to reduce volume and facilitate transport. Cutting processes play an essential role; hence, the devices used in this operation must be efficient to keep a minimum energy consumption. This study addresses the numerical evaluation of several blade profiles to find the most efficient regarding the force and work done for the cutting of tire tread. The numerical results regarding the performance of the profiles were validated experimentally confirming that the most efficient geometry between the evaluated correspond to a hollow profile.
Spread of Plasmids Carrying Antibiotic Resistance Genes in Soil-Lettuce-Snail Food Chain
Authors: Zhang Yuan , Ji Yan , Tang Xinyue , Chen Minglong , Su Jianqiang
Published: October 2023

Agricultural activities such as fertilization change the composition of antibiotic resistance genes(ARGs) and their host bacteria in agricultural fields, while complex microbial activities contribute to the transfer of ARGs and their host bacteria into crops and their transmission to humans through the consumption of agricultural products. The spread of plasmid-mediated ARGs in the farm food chain is unknown, as is the risk of their transfer to human pathogenic bacteria. Therefore, this study constructed a farmland food chain with soil-lettuce-snail as a typical structure, added genetically engineered Pseudomonas fluorescens containing multidrug-resistant plasmid RP4 to track its spread in the farmland food chain, and used different fertilization methods (no fertilization, chemical fertilizer application and manure application) to explore its influence on the spread and diffusion of ARGs and intl1 in the farmland food chain. It was found that exogenous Pseudomonas can enter plants from soil and pass into snails' intestines, and there is horizontal gene transfer phenomenon of RP4 plasmid in bacteria. The addition of exogenous drug-resistant bacteria had different effects on the total abundance of ARGs and intl1 at different interfaces of the food chain, but fertilization, especially manure, not only promoted the spread of Pseudomonas aeruginosa and the transfer of RP4 plasmid levels, but also significantly increased the total abundance of ARGs and intl1 at all interfaces of the food chain. The main ARGs host bacteria in the food chain include Proteobacteria, Bacteroides and Firmicutes, while Flavobacterium of Bacteroides is the unique potential host bacteria of RP4 plasmid, and fertilization obviously increases the abundance of Bacteroides. To sum up, this study provides reference for the risk assessment of ARGs spreading to human body through food chain.
Loneliness in the Norwegian adolescent population: prevalence trends and relations to mental and self-rated health
Authors: Parlikar Nayan , Kvaløy Kirsti , Strand Linn Beate , Espnes Geir Arild , Moksnes Unni Karin
Published: October 2023

Background
Loneliness has become a significant public health problem and should be addressed with more research on the prevalence and associations of loneliness among adolescents over a broader period. This study investigates the variations in the prevalence of loneliness among a nationally representative study population of Norwegian adolescents over the last three decades and whether age, gender, self-rated health, and mental distress are associated with these changes.
Methods
Adolescents aged 13–19 years completed the structured and validated questionnaires from the three waves of the Young-HUNT Study: 1995–1997, 2006–2008, and 2017–2019. Loneliness was measured with one item asking, `Are you lonely? Hopkins Symptom Checklist-5 was used to measure anxiety and depression (cut-off ≥ 2). Self-rated health was assessed by a single question ‘How is your health at the moment?’ Measures were provided by self-report. Descriptive analyses were stratified by age, gender, self-rated health, and mental distress. Linear-by-Linear association test across survey years was performed to test time trends of loneliness. Logistic regression was used to analyze the cross-sectional associations of self-rated health and mental distress with loneliness, adjusting for sociodemographic factors in all three waves of Young-HUNT.
Results
Loneliness prevalence doubled from 5.9% in 1995/97 to 10.2% in 2017/19 in the total population sample. The highest loneliness prevalence and an increase from 8.9% in 1995/97 to 16.7% in 2017/19 was observed in girls of 16–19 years. Among mentally distressed adolescents, loneliness increased from 22.3% in 1995/97 to 32.8% in 2006/08 and lowered to 27% in 2017/19. Increasing loneliness prevalence was seen in those with poor self-rated health, i.e., 14.6% in 1995-97 and 26.6% in 2017-19. Mental distress and poor self-rated health were associated with higher odds of loneliness in each wave (p < 0.001).
Conclusion
The results highlight the increasing burden of loneliness in the Norwegian adolescent population, especially girls. Those with mental distress and poor self-rated health have a higher risk of experiencing loneliness. Thus, health-promoting upbringing environments for children and adolescents that support mutual affinity, social support integration, and belongingness in adolescents’ daily arenas are essential.