bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of the COVID-19 pandemic on the incidence of Type 1 Diabetes Mellitus in children and adolescents in the General Hospital "Dr. Laza K. Lazarević", Šabac
Authors: Damnjanović Milijana , Radojičić Dragana
Published: December 2023

Introduction and Objectives: Over the past few years, a surge in the incidence of Type 1 Diabetes Mellitus (T1DM) has been observed worldwide, especially during the COVID-19 pandemic. The aim of our research is to shed light on the incidence of Type 1 Diabetes Mellitus in children and adolescents at General Hospital "Dr. Laza K. Lazarević" in Šabac, as well as the impact of the COVID-19 pandemic. Methodology: General Hospital "Dr. Laza K. Lazarević" in Šabac serves a population of 35,141 children aged 0-19 years from the Mačva District territory. Data were collected through a retrospective analysis of electronic medical records of children and adolescents diagnosed with T1DM at General Hospital "Dr. Laza K. Lazarević" in Šabac from January 2013 to December 2022. Results: Throughout this ten-year period, the average incidence of Type 1 Diabetes Mellitus in children under 19 was 14.80 per 100,000, with the highest incidence found in the group aged 10-14 years and the lowest incidence found in the group aged 15-19 years. During the years of the COVID-19 pandemic, a slightly higher incidence was recorded compared to the years before the pandemic, although the difference was not statistically significant. Conclusion: Based on the data from our study, it is clear that the COVID-19 pandemic has had some impact on the occurrence of Type 1 Diabetes Mellitus in children, as it is associated with a higher incidence of T1DM compared to the years preceding the COVID-19 pandemic.
General elections in Bosnia and Herzegovina in October 2022
Authors: Mijatović Marko
Published: December 2023

In this paper, we will consider the general elections in Bosnia and Herzegovina held on October 2, 2022, and the changes in the electoral legislation that came about by the decision of the so-called High Representative in Bosnia and Herzegovina, Kristijan Šmit, on election night, based on the so-called "Bonn Powers". The main intention of these measures was to unfreeze and speed up the process of forming new authorities in the entity Federation of Bosnia and Herzegovina (and to some extent resolve the political tensions between Bosniaks and Croats that have been present for years and decades), proceeding cautiously to meet Croatian demands. Yet the new solution led to a new type of problem, which significantly complicated the formation of new authorities and led to a new reaction of the High Representative, which was the introduction to new political tensions in the entity of the Federation of Bosnia and Herzegovina, but also in the country as a whole.
Pandemization and the new normal
Authors: Lukić Aleksandar
Published: December 2023

The paper investigates the phenomenon of a declared pandemic and the processes that take place within such a situation. It's about processes in education, culture, economy, and social life in general. Those processes could not have happened if the pandemic had not been declared. It can be said that we are living in a turning point that should establish a new state of affairs in public and private life. That new state of affairs implies a new paradigm representing a kind of refeudalization of various parameters related to the significant denial of various rights and freedoms. The new paradigm includes a significant degree of control, ie. various forms of supervision and forced medical treatments. The new state of affairs has its slogans such as "social distancing", "new normal", "digitalization", etc. Those slogans are contrasted with the slogans of freedom, equality, and fraternity that marked the creation of civil society during the French Revolution. The declaration of a pandemic enabled the introduction of restrictive measures that go beyond medicine and primarily relate to basic human rights and freedoms. In this way, from the sphere of medicine, it entered the sphere of philosophy, sociology, politics, and other areas of human social practice. Propaganda has produced a situation in which it has made fear a desirable state of affairs. Those who were not afraid, as a rule, were declared non-solidarity and irresponsible persons who endanger other people, the health system, the functioning of the state, etc. People agreed to the measures either out of primal existential fear or out of fear of punishment if they did not respect them. Deconstruction of the so-called old normal would also represent the deconstruction of the existing civil society and the establishment of new totalitarianism. The articles of recognized scientists, such as Kary Mullis, Luc Montagnier, John Ioannidis, etc., if they did not fit into the given matrix, were either ignored or declared unscientific. It could be argued that the declared pandemic was primarily a political project. Its factual ending also testifies to this. Pandemization entered a standby state when the Russian special military operation on the territory of Ukraine began in February 2022.
Tokyo liminal spaces as a dispersed constellation of spatial identities
Authors: Ikalović Vedrana , Covatta Alice
Published: December 2023

In a metropolis and metropolitan public space, increased attention has recently been given to overlooked and uncontrolled spaces. Considered as spatial 'voids,' 'idle spaces,' 'interstices,' and 'in-between' spaces, they all have one characteristic in common: 'the waiting for use' potential that can be ignited by users' creativity and tenacity, and with designers taking the role of 'enablers' rather than 'deciders'. Hence, urban leftover space becomes meaningful place with a strong local identity, enabling new connections and maximising its socio-spatial potential. This paper analyses Tokyo as a paradigmatic case study to investigate the roles of local spatial practices in the process of leftovers' identity (re)construction. More so than other global metropolises, the city represents a living laboratory for experimentation due to its compactness and the variety of small-scale urban patterns. A combination of ethnographic observations and visual analysis is applied as a trans-disciplinary method to investigate small-scale urban leftovers in Tokyo's traditional urban tissue of the shitamachi districts. This approach allows an understanding of how individuals transform and utilise leftovers, which become a dispersed constellation of tangible spaces of identity. Extrapolation of home into a public zone of liminal leftover space, through appropriation and care, becomes the key to the resilience of local identities.
Matter transgression
Authors: Mantz Ophélia
Published: December 2023

Post-pandemic, France is promoting new ways of inhabiting domestic space by learning from COVID. However, certain models have emerged from a slower transformation. We examine how do-it-yourself (DIY) work may indicate paradigm changes in French society. This essay describes the characteristics and changes in DIY across time in France based on the momentum created by social sciences in the 1970s. It explains how DIY is able to generate changes in people's behaviour and thus offers possible new models for economy and production. However, to play a role in both twenty-first century housing and the contemporary city, action taken on the matter must be spatially legitimised. Therefore, the historical role of homo faber and his workshop in constructing la cite is discussed. Workshops allow the transgression of current material culture led by the ideas of abundance and accumulation. Thus, DIY is viewed as a way of being in the world that allows the construction of new economic and productive models during an era of ecological transition.
What do we mean when we talk about Central European urban morphology?
Authors: Lovra Éva
Published: December 2023

The viewpoint aims to define and summarize the efforts made in Central Europe - which has ever-changing borders - on the topic of urban morphology. The paper cannot cover all endeavours; it only talks about the main directions and their representatives, which are the same as the directions of the main schools of urban morphology. The viewpoint briefly touches on the idea of Central Europe and on the roots that connect the basis of Central European urban morphology, which then split into specific approaches and directions (place, region, perception) and continued to develop independently. Regarding trends, it deals more with Hungarian aspirations. It addresses the questions posed in the title separately and provides answers to them as a conclusion.
The study of urban form in Brazil and Portugal: From a general overview to a focus on Belo Horizonte, Brasilia, and Porto
Authors: Oliveira Vitor , Pereira Costa , de Holanda
Published: December 2023

In 2010, the Portuguese-language Network of Urban Morphology (PNUM) was created under the umbrella of the International Seminar on Urban Form (ISUF). Over the last 12 years PNUM has been contributing towards the promotion of urban morphology in Brazil and Portugal, fostering collaboration between different researchers in both countries. This paper is in four parts. The first part has an institutional nature, addressing PNUM's origins, main developments, and fundamental characteristics. The second part identifies seminal morphological studies carried out by Portuguese-language researchers, making evident the influence of this intellectual heritage in the creation of PNUM. The wide diversity of present morphological research in Portugal and Brazil (with significant differences between the North, Northeast, Centre-West, Southeast and South regions) is explored in the third part. Finally, the paper addresses some fundamental issues that are being explored by the authors of this paper: i. the definition of urban morphology as a field of knowledge; II. the relationships between the physical and social dimensions of human settlements; III. the challenges of teaching urban morphology as an interdisciplinary field; IV. the innovative contributions to the development of dominant approaches in the field; and, finally, v. the relationships between scientific research and professional practice.
Feasibility and Utility of a Virtual Reality Laboratory Exercise in an Undergraduate Neuroscience Course
Authors: Broomell Alleyne P.R. , Allison Mykenzi , Ellern Gillian D.
Published: December 2023

To improve undergraduate students' understanding of neuroanatomy and structure, we leveraged existing virtual reality infrastructure to create a novel dissection assignment in an undergraduate neuroscience course. Students completed a virtual reality dissection of the central nervous system that augmented status quo instruction in lecture and textbook format. We found that such an assignment is feasible at a regional comprehensive university with intrauniversity partnerships that are mutually beneficial. Results showed positive engagement from students and feasibility of incorporating virtual reality in undergraduate neuroscience courses.
Stability analysis of rainfall-induced landslides: A case study of a hilly area in Bangladesh
Authors: Hore(PhD) Ripon
Published: December 2023

Rainfall-induced landslides stand as the prevailing geohazard in tropical and subtropical regions. The ongoing global climatic changes have introduced a wave of anomalous rainfall events across the world. These abnormal weather patterns have triggered numerous landslide incidents, resulting in significant loss of life and property. To develop early warning systems for such threats to people in mountainous areas of Chittagong, Bangladesh, it requires an in-depth understanding of the geo-environmental properties of soil slopes under heavy rainfall. Historical records reveal that rainfall in total exceeding 150–250 mm has resulted in both localized slope collapses and debris floods. When it rains heavily, rainwater infiltrates initially unsaturated slopes, elevating the degree of saturation while decreasing soil suction. Consequently, the reduced shear strength along the critical slip surface diminishes the factor of safety (FoS), and slope failure occurs. As a result, studies of soil-water characteristics have been conducted, followed by laboratory testing at the impacted sites, and the study found that rainfall and soil type (fine-grained silt) were the most critical factors behind landslides. The mechanism of slope failure is also demonstrated using a simple numerical infiltration model and a slope stability equation. The soil characteristics, the saturated volumetric water content (θs), closely match the field water holding capacity (θf), with a minor difference of 4-8%, and the drainage condition at the bottom of the slope appear to be important factors. Application of these test results to an early warning system for landslides and flash floods is finally demonstrated based on some simplifying assumptions.
Numerical assessments of observed seismic performances of Lexington Dam during the 1989 Loma Prieta earthquake
Authors: K.Chugh Ashok
Published: December 2023

Seismic performances of Lexington Dam during the 1989 Loma Prieta earthquake are assessed. Linear and nonlinear analyses are used to identify locations of tension zones where cracks are likely to occur. Numerical analyses are for longitudinal and transverse sections of the dam. Assessments of natural vibration characteristics of the dam are based on numerical simulation of geophysical and forced vibration testing procedures. Nonlinear analyses are based on equivalent linear and elastoplastic solution procedures. The acronyms of computer programs used are SHAKE, SHAKEM and FLAC. Analyses procedures and computer programs used are commonly used in dam engineering practice. Relative movements of observers representing onsite accelerometers are included. The information presented is expected to be of interest to engineers and seismologists in dam engineering practice.
Efectividad de la suplementación con micronutrientes en polvo en el estado nutricional en niños de 06 a 36 meses de edad en el Centro Materno Ollantay- San Juan de Miraflores 2019
Authors:   , Ramírez Arnao Patricia Emilia
Published: December 2023

El objetivo de este trabajo de investigación fue determinar la efectividad de la suplementación con micronutrientes en polvo en el estado nutricional en niños de 06 a 36 meses de edad en el Centro Materno Infantil “Ollantay”, distrito de San Juan de Miraflores en el 2019. La presente investigación correspondió al enfoque de tipo cuantitativo, transversal y de nivel descriptivo comparativo. La muestra fue de 100 niños atendidos durante los meses de mayo a diciembre del 2019, se aplicó como técnica la encuesta y observación, como instrumentos el cuestionario y la ficha de recolección de datos. Resultados: La suplementación de micronutrientes es adecuada en 62% (62), al inicio según indicador peso/edad 79% (79), talla/edad 91% (91) y peso/talla 77% (77), después de la suplementación normal peso/edad 85% (79), talla/edad 91% (91) y peso/talla 87% (77). En cuanto a la suplementación de hierro al inicio presentaron anemia leve 41% (41), anemia moderada 13% (13) y no presentan anemia 46% (46), después de iniciada la suplementación anemia leve 20% (20), anemia moderada 3% (3) y sin anemia 77% (77). De acuerdo a los resultados encontrados con un valor de significancia de 0,0001 (p<0,05) se establece que la variación del nivel de hemoglobina antes y después de la suplementación de micronutrientes es significativa, por lo que se puede afirmar que la suplementación es efectiva en niños de 6 a 36 meses.
Características clínico-epidemiológicas de pacientes infectados con Sars-Cov-2 en cinco hospitales de Perú, 2020
Authors:   , Vidal Castillo Clara Estela
Published: December 2023

Objetivo. Determinar las características clínicas y epidemiológicas de pacientes infectados con Sars-cov-2 en cinco hospitales de Perú, 2020. Metodología. Investigación de diseño no experimental, retrospectiva transversal, de nivel descriptivo, en una población de pacientes que pertenecen a 5 hospitales de 3 Regiones Lima, Piura y Arequipa, de donde se obtuvo una muestra equitativa de 375 paciente infectadas por el virus Sars-Cov-2 hospitalizados y tratados en dichos nosocomios, en quienes se evaluó los aspectos clínicos y epidemiológicos presentes durante su enfermedad. Resultados: Entre la sintomatología, los pacientes con Covid-19 presentaron el 69,9% malestar general, 40,5% tuvieron dolor de garganta, 12,5% escalofríos, 62,9% tuvo congestión nasal, 43,2% cefalea, 36,8% dificultad respiratoria, 30,4% dolores musculares, 18,1% tuvo dolor en el pecho, 12,5% tuvo náuseas, 14,1% presentó dolor abdominal, 26,9% dolor articular. Entre los signos, el 44% tuvo tos, 21,6% presentó fiebre, 15,2% vómitos y 22,7% diarreas. Entre las comorbilidades el 43,5% tuvo sobrepeso u obesidad, 22,9% diabetes mellitus, 21,6% hipertensión arterial y 12% enfermedad pulmonar obstructiva crónica. Entre los aspectos epidemiológicos destaca que el 16,3% de pacientes tenía edades entre 18 a 29 años, 32,5% entre 30 a 60 años y el 51,2% tuvo más de 60 años. 53,3% eran de sexo masculino, siendo la muestra distribuida por igual entre las 3 provincias, con 33,3% cada una entre Lima, Piura y Arequipa. Conclusiones: Los aspectos clínicos y epidemiológicos evaluados en los pacientes son similares en los 5 nosocomios y 3 Regiones investigadas.
Nivel de prevención de parasitosis y la presencia de anemia y desnutrición en niños menores de 5 años en el Centro de Salud Villa de Arma, Huancavelica 2022
Authors:   , Cavides Luna Edwin Adsber
Published: December 2023

Objetivo: Determinar la relación entre la prevención de parasitosis y la presencia de anemia y desnutrición en niños menores de 5 años en el Centro de Salud Villa de Arma, Huancavelica 2022. Material y método: Estudio de tipo básica, descriptiva correlacional, corte trasversal y de diseño no experimental, población de 174 madres de niños menores de 5 años que se atienden en el servicio de CRED, Centro de Salud Villa de Arma, Huancavelica, 2022 cuya muestra de 120 madres respondieron a un cuestionario con variables de caracterización y un instrumento tipo escala de 14 ítems para el nivel de prevención de parasitosis y una ficha de cotejo para la presencia de anemia y desnutrición crónica. Resultados: el 54.17% de niños menores de 5 años presenta una prevención inadecuada en referencia a la parasitosis en cambio en el 45.86% se presentó de una prevención en un nivel adecuado. Por otro lado, se encontró que el 54.17% presenta anemia y desnutrición en cambio el 45.83% no presenta ninguna de estas enfermedades. Conclusiones: La prevención de parasitosis se relaciona directamente con la presencia de anemia y desnutrición en niños menores de 5 años en el Centro de Salud Villa de Arma, Huancavelica 2022, según la correlación de Spearman de cuyo valor es 0.662, con una significancia estadística de p=0.000 siendo inferior al 0.01.
El derecho a formar una familia en relación con la creciente práctica de la maternidad subrogada - Ica, 2020
Authors:   , Anchante Gerónimo Wendy Sofía , García Chacaliaza Shiomara Paola
Published: December 2023

La tesis realizada respecto al Derecho a formar una familia en relación con la creciente práctica de la maternidad subrogada , ha permitido de parte nuestra ampliar los conocimientos de la doctrina sobre la maternidad subrogada, sucede cuando una madre embarazada ,lleva en su vientre a un bebé, pero desde el punto de visto genético y legal le pertenece a otros padres, estos temas también reciben el nombre de vientre de alquiler, ligados a su vez a los derechos de la familia, las consideraciones teóricas relacionados con el derecho genético, la importancia de la reproducción asistida, estos términos palabras o frases crecen incontrolablemente, las madres naturales deben dar al recién nacido a sus padre legales y ella renunciar al mismo, al hijo que llevo por nueve meses, no se tiene grandes avances desde el punto de vista de la legislación peruana en este tema apasionante del derecho, la ley contempla los casos, pero no niega ni prohíbe alquilar , pagar a la madre para que alquile su vientre, ello repercute en el ámbito moral, social, legal, filosófico, religioso, somos un país tradicional, ancestral , no somos liberales y esta práctica atenta contra las buenas costumbres, sin dejar de mencionar que existen chantajes con el tema en los precios, no se garantiza la entrega del recién nacido. La tesis desarrollada se realizó de acuerdo con el esquema proporcionado por la universidad, el cual contiene seis capítulos detallados al interior, las conclusiones, bibliografía. La primera conclusión , el 59,09% respondió que se encuentra de acuerdo, el 12,12% se encuentra en desacuerdo, 3,00% están totalmente en desacuerdo, 21,21% de los encuestados respondieron que no se encuentran ni de acuerdo ni en desacuerdo y el 4,55% respondieron que les parece indiferente sobre el derecho a formar una familia y el uso de las Terapias de reproducción asistida con la creciente práctica de la maternidad subrogada, la tesis fue de tipo básica, nivel descriptivo, dogmática y diseño no experimental.
Application of Ultrasonic Methods in Super POD Thickness Measurement Examination
Authors: Wardhani Rachmasari Pramita
Published: December 2023

NDT is a scientific field of engineering that includes testing and inspection of materials and equipment which is useful for evaluating a condition, finding deficiencies and defects, and also extending the useful life of the infrastructure used. The main difference between non-destructive testing and other forms of material evaluation is that non-destructive testing allows evaluation or inspection of parts on site without having to permanently modify or damage the part. In maintaining the credibility of the company's services, the company adopting NDT/NDE testing techniques in carrying out regular inspections or checks on the tools used, one of which is the application of the ultrasonic method on the Super POD (Programmable Optimum Density). Based on this background, the author chose the theme of the study to write a scientific paper entitled “Application of Ultrasonic Methods in Super POD Thickness Measurement Examination”. The SBF-624 Super POD (programmable optimum density, POD) is a trailer-mounted fracturing service blender that can blend and pump up to 120 barrels per minute of fracturing slurry. The Super POD computers precisely control the solid-to-liquid ratio of the prop pant at design values in either ramp or stair-step mode. The results of observations of objects that have been inspected using the ultrasonic method, namely measuring the thickness of the Super POD SBF 624, from the good results without any defects being detected, and cleaned in surface condition so it can be said that the machine has shown good effective results and can meet the standards for using tools for the company.
An Analysis of Written Commentary Technique on Students’ Writing Given by Teachers
Authors: Yuniko Fajrilhuda , Ilahi Rahma Kurnia
Published: December 2023

This research was based on a phenomenon that the students’ writing ability was still low. It was assumed that there were two main factors influencing the students’ writing. One of them was about facilitating the students with appropriate written feedbacks. In line with that, this research was a kind of descriptive study, which was aimed at finding a deep description of the implementation of written feedback at MAN Koto Baru Padang Panjang. Participants of the research were all English teachers there. Furthermore, the data were collected by using two instruments, documents and interview. There were two findings of the research. First, almost all of the written feedback items were provided to help students working on their grammatical mistakes or forms of the writing, it was proven by the percentage that 99.66% of the written feedback items were focused on forms whereas only 0.34% of the written feedback items were focused on contents. Second, the technique used in giving the written feedback was written commentary. This technique was used due to its effectiveness in helping the students’ writing. In short, giving written feedback through the written commentary technique is really worth for the development of students’ writing, especially for non-native of English.
Examining the impact of the COVID-19 vaccine on pneumonia cases using a SEIR type model
Authors: Karaca Vural Fatma , Kıymaz I. Onur
Published: December 2023

In this study, the effect of vaccination on the evolution of COVID19 to pneumonia was investigated using a developed SEIR-type compartmental disease model. Equilibrium points were determined for the model, its stability was examined, and the basic reproduction number was calculated. To obtain numerical solutions for the model, two periods of 62 days were used. The data was obtained from the website of the Ministry of Health of the Republic of Turkey. The effectiveness of the vaccine was examined by comparing these two periods. Graphs of the numerical solutions were then created, and their compatibility with the real data was examined.
Xây dựng công thức và quy trình pha chế theo đơn thuốc bôi da benzyl benzoat 25% dạng gel nhũ tương
Authors: Nguyễn Kim Thuận , Trịnh Ngọc Như Ý , Văn Thị Nhật Duyên
Published: December 2023

- Đặt vấn đề: Benzyl benzoat là một trong những thuốc được dùng từ lâu để điều trị bệnh ghẻ với khuyến cáo như là một “can thiệp đầu tay” có hiệu quả và tiết kiệm chi phí điều trị. Mục tiêu của nghiên cứu này nhằm xây dựng một công thức và quy trình pha chế theo đơn thuốc benzyl benzoat 25% bôi da có cấu trúc nhũ tương gel thân nước, để phục vụ cho nhu cầu điều trị của chuyên khoa da liễu.
- Đối tượng và phương pháp nghiên cứu: Đối tượng nghiên cứu là thuốc bôi da benzyl benzoat 25% dạng gel nhũ tương. Mô hình thử nghiệm được thiết kế để bào chế được chế phẩm dạng nhũ tương gel thân nước bằng phương pháp “keo ướt”; khảo sát được sự ảnh hưởng của tỷ lệ các chất nhũ hóa, tác nhân tạo gel lên độ bền và thể chất của chế phẩm. Đánh giá sơ bộ chế phẩm qua các chỉ tiêu cơ bản như tính chất cảm quan, pH, mức độ phân bố đồng đều và độ ổn định.
- Kết quả: Xác định được một công thức và quy trình bào chế gel nhũ tương benzyl benzoat 25% khá ổn định gồm có: benzyl benzoat (25%), chất diện hoạt không ion hóa (6%), carbopol 940 (0,4%), glycerin (15%), và nước cất (vừa đủ 100%). Chế phẩm thu được có thể chất mềm, mịn, màu trắng đục phù hợp với các tiêu chuẩn chất lượng đề ra.
- Kết luận: Đề tài dã xây dựng được công thức và quy trình pha chế theo đơn gel nhũ tương benzyl benzoat 25% và phù hợp với các chỉ tiêu chất lượng của mục tiêu nghiên cứu.

Abstract

- Background: Benzyl benzoate is one of the older preparations used to treat scabies with recommendations as an effective “first - line treatment” and saving treatment costs. The gold of this research is building a formula and compounding process for 25% benzyl benzoate medication under hydrophilic emulgel structure, supplying a rare preparation for currently demand of therapy in dermatology.
- Materials and methods: The materials is benzyl benzoat 25% emulgel for topical delivery. The experimental models was designed to prepare an hydrophilic emulgel by “wet gum” method; examine the influence ofthe ratio of emulsifiers, gelling agents on the stability and physical properties of thepreparation; the preliminary evaluation of emulgel via the main criteria such as: appearance, pH, homogeneity of distribution and stability.
- Results: The experimental results has determined the optimal formulation and compounding process for benzyl benzoate 25% emulgel including: benzyl benzoate (25%), non - ionic surfactant (6%), carbopol 940 (0,4%), glycerin (15%) and distilled water (q.s.100%). The finished product is soft, smooth, with milky white opaque color and comfort to quality standards of the objectives.
- Conclusion: The project has developed the formula and the compounding process of benzyl benzoate 25% emulgel and comfort to some basic quality standards objective.
Tỷ lệ biểu hiện trầm cảm ở bệnh nhân bệnh lý nguyên bào nuôi tại Bệnh viện Từ Dũ và các yếu tố liên quan
Authors: Nguyễn Trung Hiếu , Lê Quang Thanh , Huỳnh Nguyễn Khánh Trang
Published: December 2023

- Đặt vấn đề: Bệnh lý nguyên bào nuôi (BLNBN) trong thai kỳ là một nhóm bệnh lý có nguồn gốc bất thường từ bánh nhau. Tần suất mắc bệnh ở Châu Á khoảng 8 - 10/10.000 thai kỳ. Bệnh ảnh hưởng không nhỏ đến sức khỏe, tinh thần của người bệnh, về lâu dài có thể dẫn đến trầm cảm.
- Mục tiêu: Xác định tỷ lệ và các yếu tố liên quan biểu hiện trầm cảm ở bệnh nhân bệnh lý nguyên bào nuôi.
- Phương pháp nghiên cứu: Nghiên cứu cắt ngang. Dữ liệu được thu thập bằng cách phỏng vấn trực tiếp 334 bệnh nhân thai trứng tại tại khoa Ung bướu phụ khoa bệnh viện Từ Dũ TPHCM từ 01/01/2021 đến 30/06/2021. Thang đánh giá trầm cảm được sử dụng là đánh già PHQ - 9 của Primary Care Evaluation of Mental Disorders với điểm cắt là 10.
- Kết quả: Tỷ lệ bệnh nhân biểu hiện trầm cảm là 25,2%. Có 06 yếu tố liên quan gồm: tuổi < 35, sợ trì hoãn có thai/ hiếm muộn, mâu thuẫn gia đình, mong con, điều trị hóa trị, bệnh lý nền.
- Kết luận: Biểu hiện trầm cảm ở bệnh nhân BLNBN là thường gặp và cần được được chẩn đoán và điều trị sớm để giảm những tổn thất cho bệnh nhân, gia đình và xã hội.

Abstract

- Introduction: Gestational trophoblastic neoplasia (GTN) is a group of abnormal trophoblastic diseases originating from placental tissue. The disease’s prevalence in Asia is approximately 8 - 10 per 10,000 pregnancies. GTN significantly affects the physical and mental well-being of patients and may lead to depression in the long term.
- Objective: To determine the prevalence and associated factors of depressive symptoms in patients with gestational trophoblastic neoplasia.
- Methods: A cross-sectional study was conducted. Data were collected through direct interviews with 334 molar pregnancy patients at the Gynecologic Oncology Department of Tu Du Hospital, Ho Chi Minh City, from January 1st, 2021, to June 30th, 2021. The Patient Health Questionnaire-9 (PHQ-9) was used to assess depressive symptoms, with a cut-off score of 10.
- Results: The prevalence of depressive symptoms among GTN patients was 25.2%. Six associated factors were identified: age < 35, anxiety about pregnancy delay/infertility, family conflicts, desire for children, chemotherapy treatment, and underlying medical conditions.
- Conclusion: Depressive symptoms in GTN patients are commonly observed, and early diagnosis and treatment are essential to mitigate the adverse impacts on patients, families, and society.
Báo cáo ca lâm sàng: một trường hợp phẫu thuật nội soi cắt nang ống mật chủ type IB kèm biến đổi giải phẫu đường mật ở người lớn
Authors: Huỳnh Thanh Long , Nguyễn Mạnh Khiêm , Phạm Việt Khương
Published: December 2023

- Đặt vấn đề: Nang ống mật chủ là một bệnh hiếm gặp của đường mật. Biến đổi giải phẫu đường mật có thể gặp ở nang ống mật chủ. Đây là một tình huống lâm sàng hiếm gặp xảy ra trên một bệnh hiếm gặp ở người trưởng thành và cần phát hiện trước mổ để có phương hướng xử trí phù hợp lúc mổ, tránh tai biến.
- Báo cáo ca lâm sàng: Nghiên cứu hồi cứu ca lâm sàng bệnh nhân nữ 64 tuổi đã phẫu thuật nội soi cắt nang ống mật chủ type IB kèm biến đổi giải phẫu đường mật type IIIA tại Bệnh viện Nguyễn Tri Phương năm 2023. Bệnh nhân được cắt toàn bộ nang và nối gan hỗng tràng kiểu Roux-en-Y. Máu mất trong mổ dưới 100ml. Thời gian nằm viện sau mổ là 11 ngày.
- Kết luận: Phẫu thuật cắt nang ống mật chủ cần chú ý những biến đổi giải phẫu đường mật đề lựa chọn mốc cắt nang ống mật chủ phù hợp.

Abstract

- Background: Choledochal cysts is a rare disease of the biliary tract. Anatomic variation of biliary tract may occur in common bile duct cysts. This is a rare clinical situation occurring in a rare disease in adults and needs to be detected before surgery to have appropriate treatment during surgery to avoid complications.
- Case report: Retrospective study of a clinical case of a 64-year-old female patient who underwent laparoscopic excision of choledochal cysttype IB combined with an anatomic variation of biliary tract type IIIAwith Roux-en-Y hepaticojejunostomy at Nguyen Tri Phuong Hospital in 2023.Blood loss during surgery was less than 100ml. The postoperative hospital stay was 11 days.
- Conclusion: Laparoscopic excision of choledochal cyst should pay attention to the anatomic variation of the biliary tract in order to select the appropriate surgical method.
Nhồi máu cơ tim không tắc nghẽn động mạch vành: nguyên nhân, tiếp cận chẩn đoán và điều trị
Authors: Hoàng Huy Trường , Đặng Duy Phương
Published: December 2023

Nhồi máu cơ tim (NMCT) không có tắc nghẽn động mạch vành (Myocardial infarction with non - obstructive coronary arteries - MINOCA) là một thể bệnh của NMCT do nhiều nguyên nhân khác nhau, bao gồm do xơ vữa động mạch (vỡ mảng bám) và không do xơ vữa (bóc tách động mạch vành, co thắt động mạch vành, thuyên tắc động mạch vành, rối loạn chức năng vi mạch vành và mất cân bằng cung cầu oxy cơ tim) dẫn đến tổn thương cơ tim mà không phải do bệnh động mạch vành tắc nghẽn. Chẩn đoán MINOCA được thực hiện trong quá trình chụp động mạch vành sau NMCT cấp, trong đó không có hẹp ≥ 50% ở động mạch vành thủ phạm và không có bệnh lý hệ thống rõ ràng để giải thích cho biểu hiện sàng này. Tỷ lệ lưu hành của MINOCA dao động từ 1% đến 14% ở tất cả các trường hợp NMCT. Tiên lượng rất khác nhau, tùy thuộc vào nguyên nhân của MINOCA. Việc thất bại trong xác định nguyên nhân của MINOCA có thể dẫn đến việc điều trị cho những bệnh nhân này không được đầy đủ và phù hợp. Nguyên tắc chính trong việc quản lý hội chứng này là làm rõ các cơ chế bệnh sinh nhằm cá thể hóa điều trị. Bài tổng quan này nhằm nêu lên các hướng dẫn hiện tại về chẩn đoán và điều trị trên bệnh nhân MINOCA

Abstract

Myocardial infarction with non - obstructive coronary arteries (MINOCA) is a form of myocardial infarction with different causes, including atherosclerotic (coronary plaque disruption) and nonatherosclerotic (spontaneous coronary artery dissection, coronary artery spasm, coronary artery embolism, coronary microvascular dysfunction, and myocardial supply - demand mismatch) resulting in myocardial damage that is not due to obstructive coronary artery disease. The diagnosis of MINOCA is made during coronary angiography following acute MI, where there is no stenosis ≥ 50% present in an infarct - related epicardial artery and no overt systemic aetiology for the presentation. Its prevalence ranges between 1% and 14% of all myocardial infarction. The prognosis is extremely variable, depending on the cause of MINOCA. Failure to identify the underlying cause may result in inadequate and inappropriate therapy in these patients. The key principle in the management of this syndrome is to clarify the underlying individual mechanisms to achieve patient - specific treatments. This overview aims to highlight current guidelines on diagnosis and treatment in MINOCA patients.
FIXED POINT RESULTS FOR THREE MAPPINGS USING CONTRACTIVE CONDITIONS IN TVS-VALUED CONE METRIC SPACE
Authors: Patel Mamta , Sharma Sanjay
Published: December 2023

In this article, we prove fixed point theorems using c-distances for three mappings in tvs-valued cone metric space under contractive conditions. The results obtained in this paper generalize and extend the results presented in the literature. Some examples are presented to validate our obtained results.
Enhancement of The Anti-Hyperuricemic Activity of Modified Simiao Wan by Optimizing The Conditions of Extraction of The Active Compounds, Using Network Pharmacology Approach
Authors: Nguyen Thu Hang  , Than Thi Kieu Than Thi Kieu My , Nguyen Van Phuong
Published: December 2023

The objective of this study was to enhance the anti-hyperuricemic activity of modified Simiao wan (MSW) by optimizing the conditions of extraction of the active group of compounds determined from network pharmacology analysis. The main group of compounds involved in the uric acid lowering effect of MSW was identified based on the herb-compound-target network. After that, the optimal conditions of extraction of these compounds from MSW were determined using response surface methodology. Then, the biological effects of MSW extracted at optimal conditions and sub-optimal conditions were evaluated. The binding mode of the key compounds of MSW with the potent target was also explored using molecular docking and molecular dynamics. The results suggested that flavonoids, particularly quercetin, luteolin, kaempferol, and wogonin, might be important compounds involved in the anti-hyperuricemic activity of MSW. After that, the optimal conditions of extraction of flavonoid from MSW were determined, including ethanol concentration of 80% and time of extraction of 60 minutes. The results of the pharmacological assay indicated that MSW extracted at optimal conditions could significantly reduce uric acid levels compared with MSW extracted under sub-optimal conditions. The protein-protein interaction network, molecular docking, and molecular dynamics simulation showed that besides anti-hyperuricemic activity, flavonoids from MSW could also exhibit anti-inflammatory effects through inhibiting TNFα. Our study suggested that optimization of extraction based on network pharmacology analysis might be an effective approach to improve the therapeutic activity of this traditional medicine.
You Will Be Held For Questioning: The Secrets of Multiple-Choice Test Makers & Test Takers
Authors: Wisniewski Alex , Tribble Curt
Published: December 2023

No abstract present.
Algunos problemas procesales (penales) de la investigación parlamentaria: examen parlamentario de la función jurisdiccional, flujos de información y concordancia práctica
Authors: Buchhalter Brian
Published: December 2023

Las investigaciones parlamentarias son admisibles cuando tienen por objeto los mismos hechos sobre los que indaga o enjuicia la jurisdicción penal. No es constitucionalmente aceptable, la indagación parlamentaria que se dirige exclusivamente a declarar la existencia o inexistencia de ilícitos penales o administrativos. Por otra parte, la simultaneidad de actividades plantea dificultades respecto de la independencia (particularmente si se refiere a la actividad jurisdiccional) y a la imparcialidad de Jueces y Magistrados. La simultaneidad es problemática, igualmente, en lo que se refiere a las obligaciones de cooperación de las Comisiones parlamentarias de investigación (CPI) y los Tribunales. Ninguno de los dos órganos está exento de colaborar (ni siquiera cuando su actividad es secreta), siempre que el receptor de la documentación (por ejemplo) pueda mantener el mismo nivel de reserva. De otra parte, cuando la investigación es paralela y un llamado a comparecer se encuentra en prisión preventiva, carece el Tribunal de potestad para denegar la presencia de aquel ante la CPI. Finalmente, la simultaneidad de indagaciones exige garantizar la llamada «concordancia práctica» lo que se traduce en la obligación de Jueces y Magistrados de colaborar (positivamente) con la indagación parlamentaria y de abstenerse (negativamente) de influir en ella; en la obligación de las CPI de colaborar con las autoridades judiciales y a respetar la actividad judicial. Y, por último, asiste a las CPI el derecho de solicitar al Pleno la suspensión de una indagación parlamentaria que pueda entrar en inconstitucional pugna con la actividad jurisdiccional.
El proceso de Reforma Constitucional actual en la República de El Salvador
Authors: Núñez Rivero Cayetano , Núñez Martínez María Acracia
Published: December 2023

La República de El Salvador durante toda su historia se ha caracterizado por su inestabilidad política y constitucional, habiendo tenido un constitucionalismo más nominal que normativo, interrumpido por golpes de estado, sucedidos siempre de largas dictaduras de carácter militar. En la segunda parte del siglo XX tuvo lugar una cruenta y larga guerra civil, que convirtió al país en escenario de la Guerra Fría. Después del conflicto bélico, mediante los acuerdos de Paz de 1992, auspiciados por las Naciones Unidas, se instaura un régimen democrático, que permite tras una serie de reformas institucionales, tales como la creación de un Tribunal Supremo Electoral, que sustituye al viejo Consejo Nacional Electoral, reforma del código Electoral, sustitución de las Fuerzas de Seguridad por una nueva policía PNC etc., que se celebren unas elecciones donde se elimine el fraude electoral, que había sido permanente en la historia salvadoreña. Se abre de esta forma un periodo donde por primera vez la izquierda puede concurrir, produciéndose durante más de treinta años alternancia en el ejercicio del poder. En 2020 el bipartidismo quiebra, en virtud del triunfo electoral de Nayib Bukele, que se impone a los dos partidos tradicionales de derecha e izquierda: ARENA y FMLN, mediante una abrumadora mayoría. Actualmente la Constitución vigente data de 1983 y fue redactada en plena guerra, adoleciendo de un déficit de sistematización y precisando de la incorporación de los nuevos conceptos constitucionales incorporados actualmente al constitucionalismo latinoamericano.
Pengaruh Self Efficacy Terhadap Kinerja Karyawan Melalui Kepuasan Kerja Sebagai Variabel Mediasi di PT. Dunia Barusa Toyota Meulaboh Aceh Barat
Authors: Jannah Raudhatul , Husen Tamitha Intassar , Rafiie Said Achmad Kabiru
Published: December 2023

Penelitian ini terkait dengan bagaimana pengaruh self efficacy terhadap kinerja karyawan melalui kepuasan kerja sebagai variabel mediasi pada karyawan PT. Dunia Barusa Toyota Meulaboh.  Tujuan dari penelitian ini adalah untuk mengetahui pengaruh self efficacy terhadap kinerja karyawan, mengetahui pengaruh self efficacy terhadap kepuasan kerja, mengetahui pengaruh kepuasan kerja terhadap kinerja karyawan dan untuk mengetahui kepuasan kerja memediasi self efficacy terhadap kinerja karyawan. Metode dasar yang digunakan dalam penelitian ini adalah metode statistika  dengan mengolah data kuantitatif. Untuk kepentingan penelitian ini digunakan data primer yang diperoleh secara langsung dengan memberikan kuesioner kepada sampel penelitian yang berjumlah 83 orang karyawan di PT. Dunia Barusa Toyota Meulaboh. Metode analisis data yang digunakan adalah analisis Jalur (Path Analysis). Hasil penelitian ini menunjukkan bahwa terdapat pengaruh positif self efficacy terhadap kinerja karyawan dengan nilai signifikan 0,000, terdapat pengaruh positif self efficacy terhadap kepuasan kerja dengan nilai signifikan 0,000 dan terdapat pengaruh positif kepuasan kerja terhadap kinerja karyawan dengan nilai signifikan 0,000, namun kepuasan kerja tidak dapat memediasi self efficacy terhadap kinerja karyawan, hal ini dikarenakan pengaruh langsung self efficacy terhadap kinerja lebih besar daripada pengaruh tidak langsung self efficacy terhadap kinerja melalui kepuasan kerja (0,5039 > 0,4179).
Las prácticas educativas en un entorno virtual de aprendizaje: Una aproximación desde los sentidos y significados en cátedras universitarias
Authors: Tagua de Pepa Marcela Adriana
Published: December 2023

La sociedad de la información se manifiesta en el ámbito educativo con la propuesta de nuevos entornos de aprendizaje sustentados en plataformas virtuales que, aprovechando las posibilidades de las tecnologías de la información y de las comunicaciones (TIC), ofrecen nuevos espacios para la enseñanza y el aprendizaje, libres de las tradicionales restricciones de tiempo y espacio impuestas en la presencialidad, posibilitando una continua comunicación entre estudiantes y profesores.
Enseñar y aprender educación en biología con plataforma Moodle
Authors: Quse Ligia , Masullo Marina , Occelli Maricel
Published: December 2023

En los últimos años la accesibilidad de los alumnos a la información y la enseñanza escolar se han modificado en relación con la implementación de las TIC. Su uso en la escuela, a pesar de las ventajas referidas en la bibliografía, todavía enfrenta al desconocimiento y la reticencia de muchos docentes. Así, en el primer año de cursado universitario implica una serie de desafíos, no sólo para los alumnos sino para los profesores que pretenden introducirlos en un espacio de reflexión y de comunicación de saberes, para promover aprendizajes significativos. Sucede esto en Problemática de la Educación en Ciencias, asignatura del Profesorado en Ciencias Biológicas de la Facultad de Ciencias Exactas, Físicas y Naturales de la Universidad Nacional de Córdoba. En ella, se plantea un aula virtual en la plataforma Moodle como complemento a las actividades presenciales de la materia, en un intento de generar vínculos de los alumnos con el conocimiento, con sus pares y con los docentes de la cátedra. Presentamos aquí la propuesta de trabajo que ha sido muy bien recibida por los participantes.
Um olhar fenomenológico acerca das condições da população em situação de rua
Authors: Correia Ariane Malta , Santos Giovani Augusto dos
Published: December 2023

Este trabalho viabiliza dar luz acerca das pessoas em situação de rua – PSR –, através da abordagem fenomenológica-existencial, com o objetivo de investigar o sentido da palavra habitar, por meio de uma pesquisa bibliográfica do filósofo Martin Heidegger. Procurou-se compreender a relação analítica existencial entre o ser-aí, ser-no-mundo, mundanidade e a palavra habitar atrelada ao sentido de pertencimento, através de descrições de conceitos oriundos do método fenomenológico e suas contribuições. Concluindo que, por meio da linguagem, é possível acessar os reais significados e sentidos atribuídos à palavra habitar, possibilitando a compreensão da relação entre ser, mundo e pertencimento. Sendo, por conseguinte, os sentidos habitáveis por si só.
Queixa escolar: Uma proposta de intervenção do psicólogo escolar
Authors: Favarin Rafael da Nova , Souza Vera Lucia Trevisan de
Published: December 2023

Este artigo relata uma pesquisa-intervenção que investigou a dimensão que a queixa escolar assume no trabalho do coordenador pedagógico mediada pelo psicólogo escolar em encontros formativos. Adotou-se o referencial teórico da Psicologia Histórico-Cultural, cuja metodologia, calcada no materialismo histórico-dialético, possibilitou o aprofundamento e análise das expressões dos coordenadores. Os encontros foram conduzidos por uma dupla de psicólogos escolares, atravessados e mediados por produções artísticas contextualizadas aos temas, pelas sínteses que descreviam o encontro anterior, por debates e textos teóricos de apoio. Para análise, foram utilizadas as transcrições dos encontros, os registros dos diários de campo, as sínteses produzidas, as observações vivenciadas durante o processo e as entrevistas finais com cinco coordenadoras. Os resultados revelaram que a queixa escolar permanece secundária ao aluno diante dos conflitos subjacentes à escola e ao próprio coordenador pedagógico, entre eles: a crise identitária de seu papel; a falta de apoio, permanência na função e representatividade político-social; a dificuldade junto ao corpo docente, em que pesem problemas quanto ao engajamento no processo de ensino-aprendizagem e um trabalho voltado às urgências em detrimento das reais necessidades, sobretudo negligenciando a formação e a articulação dos processos escolares. Observou-se ausência de um pensamento crítico sobre a produção dos problemas na escola e a lógica da medicalização sobre as crianças. Por fim, compreendemos que encontros formativos com os coordenadores pedagógicos podem se constituir como campo e objeto de atuação do psicólogo escolar na promoção de mudanças de concepções e práticas voltadas à promoção do desenvolvimento das crianças.