bluuebunny/crossref_metadata_2025 huggingface dataset:
Verticalização de segundo molar inferior com o uso de mini-implante e cantiléver: relato de caso
Authors: Oliveira Marta Desirèe do Carmo Moreira Soares de , Gaschler Juliana Azevedo Marques , Mitsui Arthur Rafael , Azuma Ana Carolina Miyamura , Bezerra Junior Gilberto da Cruz
Published: August 2023

INTRODUÇÃO: A verticalização de molares impactados é um movimento ortodôntico complexo, mas necessário para solucionar problemas funcionais, periodontais, restauradores e pré-protéticos. OBJETIVO: O presente artigo tem o propósito de demonstrar, por meio do relato de um caso clínico, a desimpacção e verticalização do segundo molar inferior esquerdo, com uso de mini-implante e cantiléver. CASO CLÍNICO: Paciente com 22 anos de idade, apresentava má oclusão de Classe I de Angle com dentes #37 e #38 impactados. Após exodontia do #38, foi instalado um mini-implante na região do trígono retromolar esquerdo e colado um botão na oclusal do dente #37. As ativações foram realizadas mensalmente, usando cadeia elastomérica, que unia o dente ao mini-implante. Após essa primeira etapa, foi necessária a instalação de novo mini-implante entre as raízes dos elementos #34 e #35, e confeccionado um cantiléver com alças helicoidais, em fio Morealloy azul quadrado 0,016” x 0,016” da marca Morelli®. O cantiléver foi ativado mensalmente até que fosse possível a colagem do tubo vestibular dele e seguisse a mecânica de arco com alça até a verticalização total. RESULTADOS: Obteve-se a completa verticalização do segundo molar inferior esquerdo, alinhamento e nivelamento de todos os dentes. CONCLUSÕES: Os resultados para o tratamento da desimpacção e verticalização do segundo molar inferior esquerdo com uso de mini-implantes e cantiléver foram eficientes e otimizaram a mecânica realizada. Clinicamente, essa técnica auxilia a resolução do problema, minimizando a cooperação do paciente durante sua execução.
Ortopedia dentofacial: efeitos esqueléticos ou dentários? A mandíbula cresce?
Authors: Almeida Marcio
Published: August 2023

Você certamente já deve ter sido questionado acerca dos efeitos dentoesqueléticos que os aparelhos ortopédicos propiciam em pacientes com Classe II na fase de crescimento e desenvolvimento craniofacial, não é verdade? Principalmente no que tange ao crescimento da mandíbula, a pergunta que surge é: “A mandíbula cresce?” Posso dizer que comigo já aconteceu em salas de aula, em postagens no Instagram/ Facebook e até em grupos de Ortodontia no WhatsApp. Acreditem se quiser, mas, a bem da verdade, não obstante o assunto Ortopedia Funcional já permeie a nossa área há mais de cem anos, ainda gera discussões acaloradas entre os ortodontistas. No presente editorial, tomei a liberdade de discorrer, brevemente, sobre os efeitos dentoesqueléticos causados pelos aparelhos ortopédicos funcionais e/ou Ortopedia dentofacial: efeitos esqueléticos ou dentários? A mandíbula cresce? MarcioAlmeida Editor-chefe 1-4 mecânicos no tratamento da má oclusão de Classe II, mais especificamente aqueles que uso com maior frequência no consultório, que são o Bionator de Balters, o aparelho de Fränkel, o Herbst, o Twin-Force e o AEB conjugado.
Avaliação tomográfica das características cefalométricas de portadores de má oclusão de Classe III com diferentes padrões de crescimento facial
Authors: Ianick Eleandro , An Tien Li , Meloti Fernanda , Silva Ertty , Cardoso Mauricio de Almeida
Published: August 2023

OBJETIVO: O objetivo deste trabalho foi avaliar, por meio de tomografia computadorizada de feixe cônico, as características cefalométricas de portadores de má oclusão de Classe III de Angle com diferentes padrões de crescimento facial. MÉTODOS: Foram selecionados arquivos em formato DICOM de 98 indivíduos, de ambos os sexos, portadores de má oclusão de Classe III, subdivididos em três grupos: braquifaciais (n=29), mesofaciais (n=30) e dolicofaciais (n=39). As mensurações foram realizadas utilizando-se 38 variáveis (20 angulares, 17 lineares e 1 em porcentagem). Os dados foram submetidos aos testes ANOVA de uma via e de Tukey, tendo o fator Padrão Facial como variável dependente. Todos os testes foram realizados com nível de significância de 5%. RESULTADOS: Foram encontradas diferenças entre os padrões faciais analisados, especialmente nos indivíduos braquifaciais, os quais apresentaram maior ângulo sela e comprimento posterior da base do crânio, além de mandíbula mais protruída e maxila menos retruída, em relação aos demais grupos, e maior vestibularização dos incisivos superiores, com consequente fechamento do ângulo nasolabial. Indivíduos do grupo dolicofacial mostraram maior verticalização dos incisivos inferiores, com maior protrusão do lábio inferior, e a variável Wits na relação maxilomandibular apresentou maior discrepância do que o ANB, o qual pode ser influenciado pela rotação horária da mandíbula. CONCLUSÃO: As características morfológicas da má oclusão de Classe III diferiram entre os padrões de crescimento facial, podendo influenciar na elaboração de planejamentos clínicos e condutas terapêuticas.
Analysis of Cell Motility with a Successive Sequence of Images
Authors: Zlatolas Katarina , Veranič Peter , Jezernik Kristijan
Published: August 2023

Analysis of cell motility usually requires several hours of continuousvideo recording of a single view field. Consequently, the method is very much timeconsuming and only a small number of cells is usually included into analysis. To increase the number of cells monitored in an experiment we developed a simpleand expeditious method for analysing the cell motility. A combination of successive series of images of individual cells relocated on CELLocate coverslips andvector graphic editing software Adobe Illustrator 9.0 enabled simultaneous monitoring of locomotion for up to ten times more cells as with previous methods.
Secular trend in body dimensions in boys from Tuzla region in period 1980 – 1996
Authors: Hadzihalilovic Jasminka
Published: August 2023

Within 16 year-period secular trend in seven measurements of physical growth of male children and youth from Tuzla Region, was researched by corresponding analysis of the sample that involved 1329 researched subjects. Our data were compared with the results of research from 1980 in the sample of 1349 boys. Nine successive generations in 1980 and 1996, from Tuzla region, were involved in this research. Analysis of the data obtained is based primarily on scientific elaboration of the situation registered in 1996 in the tested part of the broader population, after an unnatural and extremely unfavorable period for physical growth of the large majority of that population. The aim of this research was to establish secular trend (negative or positive) for the seven measurements of physical growth of male children and youth comparing our results from 1996 to corresponding research results on growth and development from1980, the sample of about same population (nearly same number of investigated persons). Although the unfavorable war living conditions negatively affected ontogenesis of the researched subjects, body dimensions of male children and youth were established as harmonious, in the limits of average European standards. However, it seems the unfavorable living conditions caused temporary slowdown in body dimensions, so, for these generations (11 to 19 years old), we could not find any increase of mean values (for certain number) of the researched parameters in comparison with the sample from 1980 year. So, 16 year-acceleration trend for most parameters was established and it is particularly evident inpost pubertal period.
Thermal acclimatization does not affect the resting activity of type T1 trichobothrium in the fi rebug (Pyrrhocoris apterus; Heteroptera)
Authors: Škorjanc Aleš , Batagelj Samo , Drašlar Kazimir
Published: August 2023

Firebugs (Pyrrhocoris apterus) pass through the winter in adult state. They undergo a series of physiological changes in order to increase their capacity to survive at low ambient temperatures. Nevertheless, even during winter their body temperature can rise up to 28 °C for a few hours on a sunny day, which is comparable to summer conditions. To establish the impact of cold acclimatization on the function of mechanoreceptors, the resting activity of T1 type trichobothria warmed up to 20 °C is compared in cold and warm acclimatized animals, as well in animals acclimated to laboratory conditions. In cold acclimatized animals the mean resting activity is 3300 imp/min (SE 90, n=13), in warm acclimatized 3400 imp/min (SE 60, n=15), and in animals acclimated to laboratory conditions 3700 imp/min (SE 130, n=17). The similar trend is observed in the variability of inter-impulse time intervals. The mean coeffi cient of the interval variation is in both cold and warm acclimatized animals 0.28 (cold SE 0.013, n=13; warm SE 0.010, n=15), and in animals acclimated to laboratory conditions 0.33 (SE 0.012, n=17). These data show negligible differences between the three groups. We can conclude that the resting activity of type T1 trichobothrium remains limited to a narrow range, regardless of the phase of the acclimatization process.
Seasonal changes in the contents of nutrients in five macrophyte species from the lake Velenjsko jezero (Slovenia)
Authors: Mazej Zdenka , Germ Matej
Published: August 2023

The study was designed to depict the seasonal dynamic in relative abundance of macrophyte species, nutrient availability and their content in macrophytes to assess the capability of different species to store nutrients in nutrient rich lake Velenjsko jezero. The concentrations of total nitrogen and total phosphorus in the lake sediment, water and aboveground biomass of macrophytes (Nuphar luteum, Najas marina, Najas minor, Potamogeton lucens andPotamogeton pectinatus) were measured at three locations monthly from June to September 2004. Seasonal variability in the contents of total phosphorus in macrophyte tissues was high, but all examined species reached similar maximal concentration in the beginning of their growth. Later in the season, concentrations declined to a high degree. Seasonal variability in the contents of total nitrogen was smaller. Floating-leaved species Nuphar luteum was present in a low amounts and contained much more total nitrogen in its above-ground tissues than the submersed species. Because of different species lifespans, differences in the content of nutrients among species were very high in particular month. Nuphar luteum, Najas minor and Potamogeton lucens were rarely present in the lake and they contributed less to storing nutrients in their biomass. Potamogeton pectinatus was commonly present in the early summer, but in August Najas marina prevailed by far and its growth had high effect on the concentration of nutrients in sediment and water. Thereforenremoving of 1 t dry weight of Najas marina biomass from the lake would contribute to removal of 2.7 kg of phosphorus and 28.2 kg of nitrogen from the lake.
Competitive advantages of Najas marina L. in a process of littoral colonization in the lake Velenjsko jezero (Slovenija)
Authors: Mazej Zdenka , Germ Mateja
Published: August 2023

Najas marina is the dominant macrophyte species in Velenjsko jezero. It appeared in the lake in 1997 and soon prevailed over the species Myriophyllum spicatum L. and Potamogeton crispus L., which used to be the two most abundant species in the lake in the past. The physicochemical and geomorphological characteristics of the lake are discussed in relation to the attributes of Najas marina, presenting competitive advantages in this environment. Conditions in the lake such as warm water and unstable sediment enabled successful growth and life strategy of Najas marina, which is a summer-annual plant with short life cycle, quick propagation from seeds and a very extensive root system.
Using carbon fibre microelectrodes to monitor the oxidative metabolism of blowfly eyes
Authors: Meglič Andrej , Belušič Gregor , Zupančič Gregor
Published: August 2023

The oxidative metabolism in animal tissues can be conveniently monitored by measuring tissue PO2 with a carbon fibre microelectrode. We have established a recording configuration in a living animal by insertion of a carbon fibre electrode (CFE) into the retina of a blowfly (Calliphora vicina – chalky). The current flowing over an exposed carbon disc at the tip of an insulated carbon fibre with 5 µm diameter is linearly proportional to PO2 when the PO2 was varied between 0 kPa (100% N2) and 100 kPa (100% O2) in the recording chamber. The slight changes in sensitivity of CFE during the recording time were corrected by calibrationsperformed at the start and at the end of the experiments. Exposure of the eye to bright light caused a drop in tissue PO2. Hypoxia increased with the stimulation time, reaching a maximum after about 20 s (∆PO2=11.6 kPa). These results are in good agreement with direct measurements of O2 consumption in isolated eyes.
A biology teacher – a second career choice
Authors: Tomažič Iztok , Vidic Tatjana
Published: August 2023

For several years now, Slovenia has been facing a shortfall of interest in science studies. Some argue that the principal reason for this lies with inadequately trained science teachers in primary and secondary schools. We set out to find the reasons why double degree students of biology (Chemistry-Biology or Biology-Home Economics) at the Faculty of Education chose to become biology teachers, and outline certain guidelines for pedagogical work with students. The results of our survey show that the number of secondary school graduates whose first choice is either of the two biology teacher study programmes at the Faculty of Education is declining. Students who selected the programme as their second choice are mainly those who did not have enough credit points for their first options, i.e. medicine, dentistry, biochemistry, veterinary sciences or biology at the Biotechnical Faculty. Most of the students who decide to become biology teachers are female. The main motives are the students’ fondness for biology and the desireto work with children. Students (regardless of which study programme they select) have fairly similar views on teaching biology. They believe that teachers should introduce practical work in the classroom, have good relationships with students, and are experts in their field (biology). Students in general did not provide innovative ideas about teaching methods which would notbe boring or uninteresting. Their ideas reflect their own experience of teachers, which is why it is important that they are included in work with pupils as early as possible. In this way they can gain their own direct experience of teaching, which helps them to build their own unique idea of what a biology teacher should be. Also highly qualified inservice teachers (mentors) should take part in education of future biology teachers. Inservice teachers could according to functioning of future teachers’ in the classroom propose to university teacher trainers what knowledge do those future teachers lack and should gain in a faculty setting. On the basis of this information introductory science courses could be better accommodated to the needs of future teachers.
Razvoj zoofiziologije na Biološkem oddelku Biotehniške fakultete in Inštitutu za biologijo do leta 1987 – osebni pogled
Authors: Gogala Matija
Published: August 2023

V tem pregledu podajam svoj osebni pogled na začetke in razvoj zoofiziološkega laboratorija na Univerzi v Ljubljani do mojega odhoda s fakultete toda s projekcijami v sedanji čas. Za popolnejšo zgodovino laboratorija bi bil potreben dolgotrajnejši študij dokumentacijein arhivov Univerze v Ljubljani, Biološkega oddelka BF, Biotehniške fakultete in Inštituta za biologijo.
Toxicity of the organophosphorous insecticide chlormephos to the earthworm Eisenia andrei and the terrestrial isopod Porcellio scaber
Authors: Hrženjak Rok , Zidar Primož , Virant Celestina Tina , Kožuh Eržen Nevenka , Kolar Lucija
Published: August 2023

In the present study we determined the toxicity of chlormephos to two common soil organisms – earthworms (Eisenia andrei) and isopods(Porcellio scaber) using Lufa 2.2 soil. The LC50 values for the effects on earthworm and isopod survival were 58 and 76 mg/kg dry soil, respectively. Mass change of earthworms and behaviour of isopods were more sensitive end points as survival. Based on earthworm body mass changes, NOEC and LOEC values were 1 and 3 mg/kg dry soil, respectively. The earthworms did not reproduce even at the lowest chlormephos concentration (LOEC < 1 mg/kg dry soil). Isopods significantly avoided burrowing in soil treated with ≥40 mg/kg dry soil. Compared with some other organophosphate insecticides, chlormephos was highly toxic to beneficial terrestrial invertebrates.
Sekundarni metaboliti v navadni konoplji (Cannabis sativa L.) in njihova vloga pri obrambi rastline pred škodljivci in patogeni
Authors: Bitežnik Luka , Dermastia Marina , Trdan Stanislav
Published: August 2023

Navadna konoplja (Cannabis sativa L.) je razširjena rastlina z zapleteno fitokemijo in bogatim sekundarnim metabolizmom. Sekundarni metaboliti so snovi, katerih vloga je interakcija rastline z okoljem. Njihova sinteza je pogojena s prisotnostjo stresa in je energetsko zelo potratna. Rastline varujejo pred škodljivci in patogeni ter abiotskimi dejavniki. V konoplji so v največji meri prisotni kanabinodi, terpenodi in flavonoidi, skoncentrirani v socvetjih ženskih rastlin. Njihova ekološka vloga in delovanje ni povsem raziskano. Kanabinoidi Δ-9-trans-tetrahidrokanabinol (Δ9-THC), kanabidiolna kislina (CBDA) in drugi naj bi bili vpleteni v antioksidativne procese in obrambni sistem rastline, zaradi prostorsko izolirane sinteze in citotoksičnih stranskih produktov. Ob prisotnosti stresa pride do povečanja njihove vsebnosti in spremembe kemijskega profila. Stres aktivira stresne signalne molekule – jasmonsko kislino in njene derivate, ki vplivajo na sproščanje terpenodiov, ter poveča izražanje genov v fenilpropanoidni poti, ki je ključna za sintezo flavonoidov. Sekundarni metaboliti delujejo sinergično in v povezavi z mikrobiomom – endofitnimi bakterijami in glivami – negativno vplivajo na škodljive organizme ter varujejo rastlino.
Issues and Trends in Contemporary Education
Authors: Tomé José Manuel Salum
Published: August 2023

Innovation management; as well as organizations in general, public and private, deserve a continuous analysis and follow-up of the variables of the external context that impact them. In this sense, it should be noted that educational agents are the ones who do the innovation and hence their management and direction play a key role. Education professionals, more than ever, need to know how to come to understand and comprehend the complexity of what external variables mean and their impact on educational work. Next, a model and method for its follow-up is presented. It is an invitation to know and take possession as agents of change in the practice of creativity and innovation, without neglecting at any time, the impact of the external context of the school, as it occurs in the Dual Mode (school-company relationship). The school as a quality school organization and educational innovation represent two areas called to be properly related, carefully analyzed, strategically planned and encouraged for their joint development. The relationship between the school as a quality school organization and educational innovation has to be seen and justified both at the level of theoretical argumentation and in the functioning and institutional life of schools as educational spaces both in it and in the company when applying Dual mode. It has to be projected, in time, in the articulation of the educational policy of a country and in the school practices that occur in the classrooms. I believe that in our country this double task is yet to be accomplished. So far we have not managed to develop a solid tradition of pedagogical thought that has adequately explored the mutual implications between school quality and innovation as an educational process.
Phytochemical profiling and biological activities of Diplazium esculentum (Retz.) Sw.: an edible vegetable fern
Authors: Raina Kirti , Chaudhary Alisha , Sharma Purnima , Sharma Rohit , Bhardwaj Kanchan , Kumar Pardeep , Kabra Atul , Thakur Sunil , Chaudhary Ashun , Prajapati Mamta , Prajapati Pradeep Kumar , Singla Rajeev K. , Sharma Rohit
Published: August 2023

Objectives

Diplazium esculentum (Retz.) Sw. is an edible vegetable fern of the Himalayan region with high nutritional and therapeutic value owing to its richness in various secondary metabolites and both macro and micronutrients.

Content

This updated review discusses the general traditional use, ethnopharmacology, phytochemistry, nutritional value, pharmacology, and toxicity concerns of D. esculentum.

The plant parts, viz. rhizomes, shoots, fronds and leaves, have immense ethnomedicinal importance, being traditionally used to cure several health disorders. Among other pharmacological effects, this botanical reveals excellent anti-inflammatory, analgesic, antifungal, antibacterial, antioxidant, anti-leishmanial, antioxidant, anaphylactic, antipyretic, anthelmintic and hepatoprotective activities, directly attributed to the presence of many secondary metabolites. From a pharmacological point of view, the excellent antioxidant potential of D. esculentum suggests its promising use for nutraceutical or functional food formulation purposes.

Outlook

Considering the evidences on popular ethnomedicinal uses of D. esculentum as an edible vegetable, its immense bio-potential, and multiple pharmacological roles, there is a huge need to evaluate its therapeutic applications in light of standard clinical trials.
Danish 20-month-olds’ recognition of familiar words with and without consonant and vowel mispronunciations
Authors: Højen Anders , Madsen Thomas O. , Bleses Dorthe
Published: August 2023

Although several studies initially supported the proposal by Nespor et al. (Nespor, Marina, Marcela Peña & Jacques Mehler. 2003. On the different roles of vowels and consonants in speech processing and language acquisition. Lingue e Linguaggio 2. 221–247) that consonants are more informative than vowels in lexical processing, a more complex picture has emerged from recent research. Current evidence suggests that infants initially show a vowel bias in lexical processing and later transition to a consonant bias, possibly depending on the characteristics of the ambient language. Danish infants have shown a vowel bias in word learning at 20 months—an age at which infants learning French or Italian no longer show a vowel bias but rather a consonant bias, and infants learning English show no bias. The present study tested whether Danish 20-month-olds also have a vowel bias when recognizing familiar words. Specifically, using the Intermodal Preferential Looking paradigm, we tested whether Danish infants were more likely to ignore or accept consonant than vowel mispronunciations when matching familiar words with pictures. The infants successfully matched correctly pronounced familiar words with pictures but showed no vowel or consonant bias when matching mispronounced words with pictures. The lack of a bias for Danish vowels or consonants in familiar word recognition adds to evidence that lexical processing biases are language-specific and may additionally depend on developmental age and perhaps task difficulty.
A trajetória do Auditório Araújo Vianna: De 1927 a 2005.
Authors: De Bem Judite Sanson , Storck Thiago Buzatto , Venâncio Maria Geraldina
Published: August 2023

O ensaio visual tem como objetivo apresentar a trajetória percorrida pelo Auditório Araújo Vianna desde sua inauguração em 1927 na Praça da Matriz, passando por sua mudança de endereço em 1964 para o Parque Farroupilha até sua privatização em 2007. As imagens foram coletadas através de pesquisa bibliográfica e documental em sites e artigos. Este ensaio é o resultado parcial da pesquisa de tese do Programa de Pós-Graduação em Memória Social e Bens Culturais.
Uma história da patrimonialização e das políticas de preservação do patrimônio ferroviário de Pernambuco
Authors: Rocha Cardoso André Luiz
Published: August 2023

Na segunda metade do século XX, a malha ferroviária de Pernambuco passou por um processo de desativações e consequente sucateamento, seguindo a tendência nacional. É justamente nesse contexto que toma forma o processo de patrimonialização da ferrovia no estado, quando diversas iniciativas são postas em prática em favor da proteção de uma memória ferroviária que está sob risco de se perder. Dessa maneira, a partir dessas ações, vai se desenhando a compreensão de um patrimônio ferroviário pernambucano que se consolida nos anos 2000. Partindo disto, o presente artigo tem por objetivo analisar o processo de patrimonialização da ferrovia no estado de Pernambuco, sinalizando alguns marcos temporais desse processo, mostrando a ressignificação de seus elementos e então a origem das políticas de preservação voltadas ao patrimônio ferroviário no estado.
A floresta é a casa, a cozinha e o quintal: as práticas alimentares na literatura indígena de Cristino Wapichana
Authors: Silva Alessandra Tereza Mansur , Meira Roberta Barros
Published: August 2023

O território é a questão central para os povos indígenas, porque é nele que se encontram os saberes para transformar os conhecimentos na prática do bem viver. A floresta é, portanto, a casa, a cozinha e o quintal onde as práticas alimentares domésticas se materializam. Nesse sentido, o artigo analisa três obras do escritor indígena Cristino Wapichana: O cão e o curumim (2018), A cor do dinheiro da vovó (2019) e Chuva, gente! (2021). Debatemos a literatura indígena pelo viés da categoria política economia própria, artes, plantas medicinais e cosméticos, da obra Bem viver e viver bem segundo o povo baniwa no noroeste amazônico brasileiro (2019), com vistas a discutir o patrimônio e as práticas alimentares, suas formas de resistência e as ameaças na sociedade contemporânea. Palavras-chave: práticas alimentares; literatura indígena; bem viver.
Museus contracoloniais e patrimônios cosmológicos no Antropoceno
Authors: Lowande Walter Francisco Figueiredo
Published: August 2023

O artigo[1] propõe uma reflexão sobre o papel político das práticas museais e patrimoniais em tempos de catástrofes ecológicas planetárias. Ao considerar que essas transformações biogeofísicas estão intimamente relacionadas ao colonialismo, o artigo defende a construção de museus contracoloniais colaborativos como forma de potencializar redes de resistência ecológica. O artigo também considera que os saberes ecológicos tradicionais de povos ameríndios e afrodiaspóricos conformam “patrimônios cosmológicos”, ligados a temporalidades e territorialidades contracoloniais, também chamando a atenção para o cuidado necessário para que essas heranças não sejam mais uma vez apropriadas por práticas coloniais. A viabilidade de uma prática patrimonial e museal contracolonial é demonstrada a partir do projeto Museus das Rexistências, que tem se dedicado a pensar e construir museus colaborativos e sustentáveis a partir de uma perspectiva contracolonial.
A importância dos trabalhos de memória em Os amnésicos, de Géraldine Schwarz
Authors: NEVES Deborah
Published: August 2023

Escrito em um momento de avanço da extrema direita na Europa, Os amnésicos – História de uma família europeia (Les amnésiques, no original), de autoria de Géraldine Schwarz foi originalmente publicado na França em 2017 pela Éditions Flammarion e no Brasil em 2021 pela Editora Ayiné, com tradução de Ana Martini. Entre 2018 e 2021, o livro recebeu seis prêmios, entre eles o Prix du Livre Européen – que objetiva promover os valores europeus e contribuir com a difusão do “espírito europeu” como uma entidade cultural entre os cidadãos do continente – na categoria “romances e narrativas”.
Imaging findings of an extramedullary epidural metastatic small cell lung cancer tumor: a case report
Authors: Wang Caiqiong , Zhang Fan , Peng Zefei , Chen Xiao , Yang Qiuyuan , He Haijun , Tang Jie , Yang Bin
Published: August 2023

Background:

Extramedullary epidural metastatic tumors of small cell lung cancer (SCLC) are rare, and their clinical symptoms and imaging features lack specificity. This study was aimed at improving understanding of epidural metastatic SCLC tumors.

Case report:

We present the case of a 75-year-old patient with an extramedullary epidural metastatic SCLC tumor that was misinterpreted as a primary intraspinal tumor according to preoperative CT and MRI resonance imaging. Laboratory test results for CA-153 (28.30 U/mL) were substantially abnormal. A solid, well-defined, soft tissue mass approximately 0.3 cm × 1.5 cm in diameter at the seventh and eighth thoracic canals was observed on CT and MRI images. A dural tail sign was observed on contrast-enhanced magnetic MRI. Because the tumor compressed the spinal cord, the intraspinal mass was resected, and the vertebral canal was decompressed. Pathological examination confirmed the diagnosis of an extramedullary epidural metastatic SCLC tumor.

Conclusions:

Extramedullary epidural metastatic SCLC tumors lack clinical specificity. Imaging is helpful for early diagnosis, treatment, prediction of the disease course, and evaluation of curative effects. Ultimately, pathological examination and biopsy are required to confirm the diagnosis.
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection
Authors: Zhang Liqiang , Li Yize (Henry) , Kibler Karen , Kraberger Simona , Varsani Arvind , Turk Julie , Elmadbouly Nora , Aliskevich Emily , Spaccarelli Laurel , Estifanos Bereket , Enow Junior , Zanetti Isabela Rivabem , Saldevar Nicholas , Lim Efrem , Schlievert Jessika , Browder Kyle , Wilson Anjali , Juan Fernando Arcos , Pinteric Aubrey , Garg Aman , Monder Henna , Saju Rohan , Gisriel Savanah , Jacobs Bertram , Karr Timothy L , Florsheim Esther Borges , Kumar Vivek , Wallen John , Rahman Masmudur , McFadden Grant , Hogue Brenda G , Lucas Alexandra R
Published: August 2023

SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐stage immuno‐thrombotic syndromes and long COVID are limited. Serine protease inhibitors (SERPINS) regulate activated proteases. The myxoma virus‐derived Serp‐1 protein is a secreted immunomodulatory serpin that targets activated thrombotic, thrombolytic, and complement proteases as a self‐defense strategy to combat clearance. Serp‐1 is effective in multiple animal models of inflammatory lung disease and vasculitis. Here, we describe systemic treatment with purified PEGylated Serp‐1 as a therapy for immuno‐coagulopathic complications during ARDS. Treatment with PEGSerp‐1 in two mouse‐adapted SARS‐CoV‐2 models in C57Bl/6 and BALB/c mice reduced lung and heart inflammation, with improved outcomes. PEGSerp‐1 significantly reduced M1 macrophages in the lung and heart by modifying urokinase‐type plasminogen activator receptor (uPAR), thrombotic proteases, and complement membrane attack complex (MAC). Sequential changes in gene expression for uPAR and serpins (complement and plasminogen inhibitors) were observed. PEGSerp‐1 is a highly effective immune‐modulator with therapeutic potential for severe viral ARDS, immuno‐coagulopathic responses, and Long COVID.
In support of researching later-life language variation and change
Authors: Pichler Heike
Published: August 2023

Variationist sociolinguists must commit to developing age-comprehensive theories of sociolinguistic variation and lifespan change. They must extend analyses of patterns of language variation and change to include the oft-neglected later life-course, and must embrace cross-disciplinary knowledge exchange to identify and explore those ageing-associated biological, psychological and social changes that may impact language use in later life. Improved understanding of later-life linguistic diversity and instability will enhance current sociolinguistic theorizing and potentially also provide hypotheses about factors impacting language use in the early life-course. It will promote a richer understanding of the extent and interconnectedness of behaviour changes in later life. And it will also benefit the community of older adult language users by celebrating them as competent and agentive language users.
Language and aging research: contradictions and aspirations
Authors: Bowie David , Gerstenberg Annette
Published: August 2023

With the Journal of Language and Aging Research, scholars in related fields are provided with a common venue. The newly founded journal continues and accompanies the Corpora for Language and Aging Research (CLARe) network's series of conferences started in 2014. Research in this field is confronted with major challenges, including: (1) to account for specific facets of age while not ignoring its inherent dynamics of aging; (2) to promote expertise in different related linguistic disciplines and at the same time develop its a coherent visibility; (3) to avoid stereotypes while addressing specific communicative issues in the society, as well as in families and in care institutions, covering an ever growing range of languages and varieties. The genuinely digital format is aimed at providing an open platform for innovations in the field.
Flexible transparent electrode with embedded silver mesh by eco-friendly polymer solution-assisted metal transfer process
Authors: Kim Han-Jung , Park Jeongmin , Kim Junhee , Ko Yohan , Kim Yoonkap
Published: August 2023

Flexible transparent electrodes (FTEs) with an embedded metal meshes play an indispensable role in many high-performance optoelectronic devices due to their excellent mechanical stability and low-surface roughness. However, great challenges remain for achieving simple, cost-effective, and environmentally friendly manufacturing of FTEs with embedded metal mesh. In this work, a vacuum-free, mask-free, and plating-free fabrication technique is proposed for FTEs with embedded silver (Ag) mesh by combining an ink-jet printing technique and a newly developed eco-friendly polymer (polyvinyl alcohol) solution-assisted metal transfer process that does not use organic solvents. The fabricated FTEs exhibit excellent optoelectronic performance with an electrical resistance of ~ 1.6 Ω and an optical transmittance at 550 nm of ~ 85.98%. The FTEs with embedded Ag mesh show strong adhesion to the substrate due to their morphology features. The proposed technique offers a promising fabrication strategy with a cost-effective and environmentally friendly process for high-performance printed flexible electronics.

Graphical abstract
Virgin Territory: Configuring Female Virginity in Early Christianity By J. K. Lillis (2023)
Authors: Sellick Jeannie
Published: August 2023

Virgin Territory: Configuring Female Virginity in Early Christianity By J. K. Lillis (2023) Oakland: University of California Press, xvi + 222pp.
Socialinė pedagoginė pagalba jaunesniojo mokyklinio amžiaus vaikams, patyrusiems tėvų skyrybas: socialinių pedagogų požiūris
Authors: Braslauskienė Rasa , Tolutienė Gitana , Jacynė Reda
Published: August 2023

Straipsnyje pristatomas socialinių pedagogų požiūris į socialinės pedagoginės pagalbos galimybes jaunesniojo mokyklinio amžiaus vaikams, patyrusiems tėvų skyrybas. Nustatyta, kad pagalbos teikimas vaikui apima individualią pagalbą, grupinius užsiėmimus, siekiant pažinti vaiką ir jo artimą aplinką, pagalbos teikimo metu yra bendradarbiaujama su vaiko tėvais ir kitais švietimo pagalbos specialistais, padedant vaikams įveikti sunkumus ir vidinius išgyvenimus, kuriant palankias sąlygas ugdymosi procese.
Tensile and microstructural behavior of gas-tungsten-arc-welded electrolytic tough pitch copper joints
Authors: Amarnath Veeraswamy , Karuppuswamy Palaniswamy , Rajendran Chinnasamy
Published: August 2023

Electrolytic tough pitch (ETP) copper is extensively used in the manufacturing of electrical machines and automobiles. Compared with other pure coppers, ETP copper has lower weldability. Therefore, this study analyzes the weldability of ETP copper using the gas tungsten arc welding (GTAW) process. GTAW can be performed using constant-current (CC) and pulsed-current (PC) modes. Consequently, the properties of the joints fabricated using both modes are compared and analyzed in this study. The results show that the joint efficiencies of GTAW-CC and GTAW-PC joints are 81 and 89%, respectively. The optimal heat input and pulsating action in PC mode produce refined grains in the weld zone and heat-affected zone, resulting in a higher joint efficiency.
Африка 2023: Возможности и риски
Authors: Маслов Андрей
Published: August 2023

Экспертно-аналитический справочник для представителей бизнеса, российских исследовательских центров, институтов развития и органов исполнительной власти подготовлен Центром изучения Африки НИУ ВШЭ. В издании представлены обобщения актуальной информации о современном экономическом положении и политическом устройстве стран Африки, их интересах, возможностях для развития сотрудничества с ними и угрозах, которые необходимо принять во внимание.
Posterior Reversible Encephalopathy after Quetiapine Overdose
Authors: Kim Min , Jeon Jae Hyun , Han Man Gyeong , Shin Dong Hoon
Published: August 2023

Quetiapine is an atypical antipsychotic drug that can cause sinus tachycardia, hypotension, coma, etc. with overdose, and rarely convulsions, rhabdomyolysis and neuroleptic malignant syndrome. Posterior reversible encephalopathy syndrome usually occurs in association with hypertension, but can occur rarely in rhabdomyolysis accompanied by acute kidney injury and arginine vasopressin axis hyperstimulation. We report the experience of a patient hospitalized with a quetiapine overdose who developed drug-induced rhabdomyolysis and reversible encephalopathy without hypertension after acute renal injury.
New-onset Refractory Status Epilepticus after BNT162b2 mRNA COVID-19 Vaccination
Authors: Kim Hyun Kyung , Jang Ye Ji , Seo Taeho , Roh Yoo Jeong , Shin Jung-Won
Published: August 2023

Increasing importance of vaccination during coronavirus disease 2019 (COVID-19) pandemic, several vaccines were developed. Messenger RNA (mRNA) vaccines including BNT162b2 (Pfizer, New York, NY, USA; BioNTech, Mainz, Germany), mRNA-1273 (Moderna, Cambridge, MA, USA) have been disclosed side effects such as thrombocytopenia, myocarditis and headache in general. In addition, adverse effects due to autoimmune responses induced by spike glycoproteins of mRNA vaccines are rarely reported such as the Guillain-Barre syndrome, autoimmune encephalitis and so on. Herein, we report a rare case of encephalitis with new-onset refractory status epilepticus after BNT162b2 mRNA COVID-19 vaccination improved with immune therapy.
Generalized Tetanus Treated with Intrathecal Baclofen Infusion
Authors: Mun Yeon-Jung , Son Wonjeong , Byeon Gyeong-Jo , Lee Eun Hwa , Shin Jin-Hong
Published: August 2023

Tetanus is a bacterial infection by Clostridium tetani. Its neurotoxin causes spastic paralysis and autonomic dysfunction. Intrathecal infusion of baclofen has been suggested as a pertinent treatment for generalized spasm. Our case describes a patient who had a severe generalized form of tetanus, and was effectively treated with intrathecal baclofen infusion. He showed cerebral and brainstem dysfunction during baclofen infusion, which were reversed without sequelae when baclofen was discontinued.
Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review
Authors: Wu Yuan Seng , Lee Michelle Felicia , Guad Rhanye Mac , Ozeer Fathima Zahraa , Velaga Appalaraju , Subramaniyan Vetriselvan , Fuloria Neeraj Kumar , Fuloria Shivkanya , Choy Ker Woon , Lee Sze Meng , Gopinath Subash C.B. , Verma Amita , Lau Tze Pheng
Published: August 2023

Drug resistance is the main issue causing the treatment failure of anticancer drugs. This issue has urged researchers to search for new substances from medicinal plants, which are widely reported as the good sources of anticancer agents. Quisqualis indica is a plant belongs to Combretaceae family, known as Rangoon Creeper, which can be found abundantly in tropical countries and distributed profusely as a wild shrub. It has been widely used traditionally and scientifically claimed to process various therapeutic activities. It has recently been reported to possess various potential anticancer activities against different cancers. Looking at its availability in almost all seasons and grow fast, it is an arising source of herbal medicine in the discovery of anticancer drugs economically. Besides, Q. indica is enriched with several secondary metabolites of interest, which are responsible for the positive findings for its anticancer potentials. In this review, we aim to decipher and discuss the anticancer activities of Q. indica crude extracts and isolated phytochemicals as evidenced in preclinical models, as well as the associated molecular mechanisms. More preclinical investigations on its anticancer potentials should be conducted before translation to clinical testing.
Genetic Association Study of Stat4 Polymorphisms and Type 1 Diabetes in Pakistani Children
Authors: Rafaqat Sana , Manzoor Jaida , Adrees Maria , Hamid Hafsa , Kamal Asifa , Bashir Rasheeda
Published: August 2023

The present study investigated the relationship of STAT4 single nucleotide polymorphisms (SNPs) rs7574685, rs10181656, and rs3821236 with T1D susceptibility visiting tertiary care hospital in Lahore, Punjab, Pakistan. One hundred and fifty-five T1D patients and one hundred and five healthy individuals were enrolled. An expert endocrinologist collected the clinical data of T1D patients. The genotyping of three potential STAT4 SNPs was performed through Tetra ARMS-PCR assay. The relationship between SNPs and T1D susceptibility under several genetic models, including dominant, recessive, and codominant models, was assessed by regression analysis. All clinical features of T1D demonstrate a significant difference from control groups (P<0.01) except blindness. The characteristic biochemical analysis determined that participants with T1D had significantly higher fasting blood glucose levels and glycated hemoglobin (HbA1c) levels than the control group (P<0.01). Genetic analysis of rs7574685 depicts GT genotype was found to be the risk allele for the development of T1D when compared to the control group. For rs10181656 and rs3821236, the GC genotype and GA genotype were observed to be the risk alleles in the T1D cases as compared to the control group (P=0.04, P<0.01, respectively). Genetic models showed that the STAT4 GG genotype of rs7574685 in the dominant model (OR=1.73, 95% CI=1.05-2.86), GC genotype of rs10181656 in the codominant model (OR=2.079, 95 % CI=1.16-3.71), and AA genotype of rs3821236 showed significant risk association with T1D (OR=3.486, 95% CI=1.72-7.03). It is concluded that the risk of T1D is highly correlated with the STAT4 variants of rs7574685 and rs10181656 among children of the Pakistani population.
Forensic medical cytological examination of the trace evidence on the knife’s blade in the case of multiple penetrating stab/cut wounds in the chest with lung damage: a case report
Authors: Kidralieva Anna P. , Fedorovtsev Andrey L. , Kidraliev Ruslan R.
Published: August 2023

Various trace evidence are often found on the instruments of mechanical injury, including microparticles of humans damaged organs and tissues. The detection of cells and microparticles of organs and tissues on the instrument of injury confirms its contact with the human body, which is of great evidentiary value.
The article presents the results of forensic medical cytological examination of biological evidence taken from the knifes blade in the case of multiple penetrating stab/cut wounds in the chest that result in lung damage. Microscopic preparations were made from the traces on knifes blade, which were stained with fluorochrome solutions (0.0005% aqueous solution of atebrine and 0.01% solution of acridine orange). The study was performed using the luminescent microscope Leica DM2500 (20 and 60 lenses, 10 eyepiece). The examination of microparticles of the striated skeletal muscle revealed areolar connective and fat tissues with capillary and arteriole fragments. The isolated mesothelial cells and type II pneumonocytes were also detected. Fibers of the striated skeletal muscle tissue looked like long multinucleated cells with distinguishing cross-striation. The areolar connective tissue was represented by loosely arranged fibers embedded in the ground substance. Fragments of the fat tissue looked like the clusters of round and oval large cells, tightly pressed together, with capillaries, and arterioles in between. Y-chromatin was detected in the nuclei of most cells. In addition, human blood was found on the knifes blade.
Thus, the study revealed that tiny particles of tissues and isolated human cells of the male genetic sex were detected, their organtissue affiliation was established, which is a valuable diagnostic finding, because it confirms the contact of the trauma instrument with the human body.
Instalación de sistema fotovoltaico en un almacén de cítrico en el puerto de Cienfuegos, Cuba.
Authors: Gomez Sarduy Julio Rafael
Published: August 2023

En el presente trabajo se evalúa la implementación de paneles solares en el almacén de cítrico de la empresa ESPCentro. Se realizaron mediciones de las estructuras y se observaron las orientaciones óptimas para mejorar el rendimiento. El sistema se simuló con el software PVSyst versión 6.7. El sistema muestra un potencial de generar 1173 MWh/año con un costo de Inversión de 1,146,960 USD que se recuperaría en 10 años considerando los ahorros de electricidad, con un VAN de 677,229 USD en 25 años y una TIR de 14.86%. Adicionalmente, se reducirá la demanda de electricidad generada a partir de combustibles fósiles, reduciendo así la emisión de gases de efecto invernadero.
Evaluación energética de la co-combustión de contenido ruminal-metano en frigoríficos y mataderos del departamento de Córdoba-Colombia
Authors: Rhenals Julio Jesús David , Mendoza Fandiño Jorge Mario , De La Vega González Taylor De Jesús , Sofán German Stiven Javier
Published: August 2023

La generación de energía por medio de fuentes renovables ha ganado importancia en campos investigativos de la ingeniería gracias a los efectos adversos que generan los combustibles fósiles, bajo ese contexto, la generación de energía por medio de biomasa residual presenta grandes ventajas debido a su potencial y bajo costo. El departamento de Córdoba es una zona la cual actividades como agricultura y ganadería predominan la economía, de esta ultima se obtiene el material ruminal bovino que podría ser aprovechado como fuente de energía debido a su capacidad energética y a su vez la reducción del impacto ambiental. En este trabajo se evalúa la co-combustion de la mezcla Contenido ruminal-Metano en plantas de sacrificio con miras a su aprovechamiento energético. Para ello se realizó una caracterización de la biomasa con miras a su aprovechamiento energético donde se realizaron actividades como, análisis último, granulometría, densidad real, aparente, porosidad, curvas de secado para determinar la cinética de la biomasa y un modelo de combustión adiabática. Los resultados obtenidos muestran un poder calorífico de 10229.80 kJ/kg, granulometría de 1.70 mm, una densidad real, aparente y una porosidad de 1.631, 0.750 (g/cm3) y 0.528 respectivamente, una relación aire-biomasa de 2.55, temperatura de llama adiabática de 1598°C y una eficiencia del 87% del proceso donde se concluyó que existe un potencial energético que puede ser aprovechado para la sustitución de metano como combustible, sin embargo, se deben realizar diferentes caracterizaciones fisicoquímicas en distintas épocas del año para analizar las diferencias que presentan la biomasa mencionada.