bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi Elektronik Sistem Audit Mutu Internal Menggunakan Metoda Questionnaires
Authors: Semnasti Munengsih Sari Bunga , Semnasti Moh. Ali Fikri , Semnasti Fachrul Pralienka B.M , Semnasti Lely Maria Kova
Published: November 2023

Pengelolaan Audit Mutu Internal (AMI) yang membutuhkan berbagai dokumen sesuai Standar Nasional Pendidikan Tinggi (SN-DIKTI) seringkali memakan waktu lama dan menghadirkan kendala dalam pengolahan data. Untuk mengatasi tantangan ini, dibutuhkan sistem yang dapat efisien dalam pengelolaan data audit. Metode kuantitatif, seperti penggunaan kuesioner, menjadi penting dalam mengukur persepsi dan preferensi pengguna terhadap elemen-elemen ergonomi dan desain produk dalam sistem audit mutu internal. Melalui kuesioner yang terstruktur, data kuantitatif yang signifikan dapat dikumpulkan dari berbagai level pengguna sistem. Dalam penelitian ini, kuesioner disebarkan kepada 5 level pengguna untuk mengukur kelayakan Elektronik Sistem Audit Mutu Internal. Hasil uji validitas Pearson menunjukkan nilai r-tabel sebesar 0,754. Uji reliabilitas menggunakan metode Cronbach’s Alpha menghasilkan nilai 0,982, menunjukkan tingkat keandalan yang tinggi. Pengujian kualitas software dengan model ISO 9126 menghasilkan rata-rata nilai 80,73% dari 7 responden, yang menunjukkan bahwa aplikasi masuk dalam kategori "Memuaskan". Dalam rangka meminimalkan kendala pengolahan data AMI, penggunaan metode kuantitatif dan kuesioner telah terbukti efektif dalam mengukur kelayakan sistem. Ini membantu memastikan bahwa sistem AMI dapat memberikan hasil yang efisien dan memuaskan sesuai dengan SN-DIKTI.
Analisis Pengendalian Kualitas Produk Teh Wangi CV. XYZ dengan Metode Total Quality Control (TQC)
Authors: Semnasti Isna Nugraha , Semnasti Tivani Nava Arier , Semnasti Achmad Gufron
Published: November 2023

Produk yang berkualitas akan memberikan keuntungan bisnis bagi produsen, dan tentunya juga dapat memberikan kepuasan bagi konsumen serta menghindari banyaknya keluhan para pelanggan setelah menggunakan produk. CV. XYZ merupakan salah satu perusahaan yang bergerak di bidang industri teh. Produk yang dihasilkan adalah teh wangi dengan berbagai macam jenis yang dihasilkan diantaranya teh 2tang hijau (biasa), teh 2tang premium dan teh 2tang super. Dalam penelitian ini penulis akan meneliti pengendalian kualitas yang akan dilakukan di perusahaan CV. XYZ. Dalam proses produksi di CV.XYZ pada proses produksi sampai dengan pembungkusan te masih terdapat ketidaksesuaian yang akan mengakibatkan produk tersebut tidak dapat dikirim kebagian pemasaran dan akan mengakibatkan kerugian bagi perusahaan jika dibiarkan terus menerus. Penelitian ini bertujuan untuk menganalisis kualitas produksi berdasarkan jenis teh menggunakan Quality Control (QC) di CV. XYZ. Metode yang digunakan dalam penelitian ini menggunakan metode kuantitatif. Untuk proses analisis data menggunakan metode Statistical Quality Control (SQC) atau Statistical Proses Control (SPC) yaitu menggunakan Peta Kendali C, Diagram Control Cacat C 100% Inspection, Diagram Sebab Akibat dan menggunakan Metode Kaizen. Faktor-faktor yang menyebabkan kerusakan produk yaitu faktor manusia, mesin, metode, dan material. Dari hasil yang didapat menunjukkan bahwa perlu dilakukan pengendalian kualitas produksi agar kualitas produk yang dihasilkan dapat lebih baik lagi.
Peningkatan Kinerja Sustainable Tourism Menggunakan Integrasi Metode IPA dan KANO (Studi Kasus: Desa Wisata Pantai Biru, Madura)
Authors: Susilowanto Dhony , Agustina Fitri , Khusnul Khotimah Bain
Published: November 2023

Wisata dapat berkembang apabila kelestarian lingkungan, ekonomi, sosial, dan budaya dapat dijaga, hal tersebut dapat disebut sebagai wisata berkelanjutan (sustainable tourism). Desa wisata memiliki peran penting dalam sektor perekonomian, yaitu menyediakan lapangan pekerjaan untuk masyarakat sekitar. Wisata Pantai Biru merupakan salah satu obyek wisata yang memiliki potensi untuk berkembang, namun berdasarkan data jumlah wisatawan pada tahun 2021 hingga 2022 mengalami penurunan signifikan. Penurunan jumlah wisatawan tersebut dikarenakan pengelolaan destinasi wisata yang kurang optimal, diantaranya fasilitas, kebersihan, wahana, dan sumber daya manusia (SDM). Tujuan dari penelitian ini yaitu untuk meningkatkan kinerja pengelolaan wisata Pantai Biru dengan memperhatikan aspek-aspek sustainable tourism. Metode yang digunakan adalah integrasi pendekatan IPA dan KANO. Metode IPA digunakan untuk memetakan rata-rata kinerja dan harapan. Sedangkan metode KANO untuk mempertimbangkan tingkat kepuasan pelanggan. Indikator sustainable tourism yang perlu ditingkatkan yaitu pada kategori indikator rough stone dan defenseless strategy point. Indikator yang harus dipertahankan antara lain indikator yang berkategori major wepon, beginning jewelry, dan precious treasure yang terdiri dari 13 indikator.
Analisis Beban Kerja Mental Pada Dosen dengan Perbedaan Jenjang Jabatan dalam Suatu Organisasi
Authors: Semnasti Putri Indrayana , Semnasti Aiza Yudha Pratama , Semnasti Dina Rachmawaty , Semnasti Muhammad Iqbal Faturohman
Published: November 2023

Pada penelitian ini menjelaskan tentang dosen yang berada di Kampus Institut Teknologi Telkom Purwokerto yang memiliki Jabatan Struktural (Wakil Rektor, Dekan, Wakil Dekan, Staff, Sekretaris Prodi, Ketua Kelompok, Kepala Urusan, Kepala Bagian, Ketua Program Studi) dan Non-Struktural (Dosen) dengan melihat struktur organisasi yang ada, dosen Non-Struktural memiliki tugas utama seperti penelitian, pengabdian masyarakat dan pendidikan, sedangkan dosen dengan Jabatan Struktural memiliki tugas tambahan selain tugas utama yang dimiliki dosen Non-Struktural, sehingga perlu dilakukan pengukuran dan analisis beban kerja mental untuk mengetahui bagaimana tingkat beban kerja mental yang dirasakan dosen dengan perbedaan jabatan tersebut. Metode yang digunakan dalam penelitian yaitu NASA-TLX, dengan teknik pengambilan data, observasi, wawancara dan pengisian kuesioner, data populasi yang ada sebanyak 175 dosen, setelah dilakukan uji kecukupan data menggunakan perhitungan slovin dengan teknik Disproportionate Stratified maka diperoleh sampel sejumlah 123 dosen. Hasil penelitian menunjukkan bahwa dari kelompok jabatan yang ada didapatkan bahwa seluruh jabatan memiliki beban kerja mental dalam kategori tinggi dilihat dari rata-rata skor NASA-TLX, dimana Kepala Bagian menjadi jabatan dengan skor NASA-TLX tertinggi dengan skor 63. Dari uji regresi yang dilakukan tidak ditemukan adanya pengaruh antara posisi jabatan dalam organisasi dengan beban kerja mental.
Gagasan Bank Sampah Untuk Membangun Sustainable City
Authors: Emir Zanggi Muhammad Zulfikar , Novita Sari Rizqi
Published: November 2023

Sampah adalah salah satu permasalahan utama yang ada di seluruh kabupaten/kota baik itu kota besar seperti Jakarta, Surabaya, Medan maupun kota-kota kecil lainnya di Indonesia. Manajemen pengelolaan sampah di Indonesia masih terbatas pada pemilahan sampah yang kemudian diberikan perlakuan / treatment sesuai klasifikasi sampah tersebut. Misalnya saja untuk sampah organik, sampah tersebut dikumpulkan kemudian dijadikan sebagai bahan pembuatan pupuk kompos. Sampah anorganik yang bisa didaur ulang seperti plastik dan kaca, dilakukan recycle untuk membuat bahan yang sama yaitu plastik dan kaca. Ruang lingkup penelitian ini adalah memberikan gagasan atau ide terkait pengadaan unit lembaga bank sampah yang mengelola sampah layaknya bank konvensional yang memberikan nasabahnya saldo dan manfaat atas partisipasinya dalam menabung sampah. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan memanfaatkan data-data dan juga proyek studi tertulis. Berdasarkan penelitian ini dapat disimpulkan bahwa secara teori, gagasan atau ide terkait unit bank sampah ini secara umum dapat memberikan manfaat bagi masyarakat atas keikutsertaannya dalam mengumpulkan sampah dan turut serta membangun kota yang berkelanjutan (sustainable city) sesuai dengan komitmen SDGs 2030 (Sustainable and Development Goals) yang ke-11 yaitu sustainable cities and communities.
Pengendalian Kualitas Produk Avtur Kilang Pertamina Internasional RU IV Cilacap Menggunakan Statistical Process Control dan Analisis Kapabilitas Proses
Authors: Prasetya Alfina Putri , Semnasti Famila Dwi Winati
Published: November 2023

Kebutuhan bahan bakar sebagai salah atu penggerak roda transportasi di Indonesia diperkirakan terus meningkat dan berdampak pada permintaan yang semakin tinggi. Pesawat merupakan bagian dari transportasi umum dengan bahan bakar utama yaitu avtur. Tingginya permintaan mengharuskan perusahaan untuk terus memastikan bahwa produk avtur yang dihasilkan oleh PT Kilang Pertamina Internasional Refinery Unit VI Cilacap memenuhi spesifikasi dan sesuai dengan kebutuhan pelanggannya, yaitu industri penerbangan. Salah satu indikator baik tidaknya kualitas dari avtur adalah kandungan mercaptan sulphur yang tidak boleh lebih dari 0,003%. Oleh karena itu, diperlukan pengukuran dan evaluasi terhadap kinerja proses produksi avtur melalui pendekatan Statistical Process Control dan analisis kapabilitas proses. Hasil penelitian ini menunjukkan bahwa kinerja proses dari PT Kilang Pertamina Internasional Refinery Unit VI Cilacap sudah cukup baik dengan nilai indeks kapabilitas proses (Cp) > 1 pada tahun 2021 dan 2022. Hal ini menunjukkan bahwa Perusahaan telah memiliki komitmen yang tinggi terhadap peningkatan mutu secara berkelanjutan.
Penerapan E-Business dan Teknologi Informasi dalam Revolusi Industri 5.0
Authors: Resmi Hayati Kinanti , Nugraha Isna , Sholeha Fitriatus , Adriyanto Albertus , Astutik Rossa Lina
Published: November 2023

Revolusi Industri 5.0 telah mengubah fundamental cara perusahaan beroperasi, dengan peran penting yang dimainkan oleh E-Bisnis dan Teknologi Informasi. Di tengah transformasi ini, E-Bisnis, sebagai kunci bagi ekonomi digital, telah menghadirkan perubahan radikal dalam cara bisnis menjalankan operasinya. Dengan adopsi teknologi seperti Internet of Things (IoT), analisis big data, dan komputasi awan, E-Bisnis telah memberdayakan perusahaan untuk memaksimalkan efisiensi, merespons perubahan pasar secara cepat, dan memberikan layanan yang lebih baik kepada pelanggan.Teknologi informasi, sebagai pendorong utama di balik Revolusi Industri 5.0 telah memungkinkan perusahaan untuk mengotomatisasi proses produksi, mengoptimalkan rantai pasokan, dan mengintegrasikan data dari seluruh spektrum operasi mereka. E-Bisnis dan Teknologi Informasi menjadi pendorong utama dalam perubahan revolusioner ini. Perusahaan yang mampu mengintegrasikan E-Bisnis dan Teknologi Informasi secara efektif akan memiliki keunggulan kompetitif yang kuat dalam dunia yang semakin terhubung secara digital. Revolusi Industri 5.0 menawarkan peluang besar bagi perusahaan yang siap mengadopsi teknologi ini dengan bijak dan memahami cara teknologi informasi membentuk masa depan bisnis.
Analisis Ketersediaan Material Produksi pada PT. X dengan Menggunakan Pendekatan Sistem Dinamis
Authors: Semnasti Dwi Sukma Donoriyanto , Semnasti Nur Rahmawati
Published: November 2023

Manajemen material adalah bagian integral dari manajemen rantai pasokan dan dapat memiliki dampak besar pada profitabilitas dan kinerja keseluruhan perusahaan. Dengan manajemen material yang baik, perusahaan dapat mengurangi biaya, meningkatkan efisiensi, dan meningkatkan kepuasan pelanggan. PT. X merupakan perusahaan manufaktur yang memproduksi teh. Perusahaan selama ini mengalami kendala dalam memanage material sebagai bahan baku produknya. Pendekatan untuk mengatasi permasalahan yang digunakan dalam penelitian ini adalah menggunakan pendekatan system dinamis dengan bantuan software vensim. Hasil yang didapatkan dari penelitian ini adalah terdapatnya gap yang tinggi antara permintaan teh dengan ketersediaan bahan baku teh di Gudang. Ketersediaan bahan baku yang sangat melimpah bila dibandingkan dengan permintaan mengakibatkan besarnya biaya simpan serta Perusahaan juga harus menganggung biaya atas kerusakan barang yang disimpan. Sebaliknya kekosongan persediaan bahan baku menyebabkan penurunan tingkat kepuasan dari pengguna produk. Skenario perbaikan yang diusulkan dalam penelitian ini adalah dengan melakukan monitoring ketersediaan bahan baku secara berkala. Pemantauan secara berkala dapat membantu mengetahui keadaan terkini dari stok barang yang dimiliki.
Analisis Pengendalian Kualitas Produk Kaos PT. XYZ dengan Metode Six Sigma dan Kaizen
Authors: Semnasti Rr. Rochmoeljati , Nugraha Isna , Semnasti Tivani Nava Arier , Semnasti Santoso Bayu Hernanda
Published: November 2023

Perusahaan konveksi PT. XYZ merupakan perusahaan yang bergerak dalam bidang industri konveksi yang jika diukur perusahaannya masih berada dalam skala produksi menengah atau dapat digolongkan pada skala perusahaan baru. Konveksi PT.XYZ memiliki fokusan produksi utamanya yaitu kaos. Dalam penelitian ini ada beberapa cacat produk yang ada yakni sablon salah cetak, jahitan lepas, dan sablon rusak. sehingga perlu dilakukan pengendalian kualitas dengan metode six sigma. Penelitian ini bertujuan untuk meningkatkan kualitas produksi pada perusahaan. Pada penelitian ini hasil analisis DMAIC (Define, Measure, Analyze, Improve, Control) yang didapatkan yakni dengan pengujian kualitas kaos sablon pada proses produksi menghasilkan kegagalan sebesar 1.198 unit, nilai Defect Per Million Oppurtunities (DPMO) sebesar 58081 dan kemudian di konvesi ke level sigma menjadi 3,08 yang menunjukkan bahwa level sigma berada di rata-rata industri Indonesia. Dapat dijelaskan bahwa kemungkinan kerusakan sebesar 58081 untuk sejuta produksi. Hal ini menunjukkan pola DPMO dan pencapaian sigma yang belum konsisten, yang menunjukkan bahwa pola produksi belum dikelola dengan tepat dan masih perlu perbaikan dan perlu adanya perbaikan kualitas pada proses produksi kaos sablon agar dapat mencapai zero defect.
Analisis Shift Kerja Terhadap Kelelahan Pegawai Produksi Melalui Pengukuran Beban Kerja Fisik Menggunakan Metode Cardiovasculair Load (CVL) dan Perhitungan Konsumsi Energi Pada Perusahaan Pabrikasi di Surabaya
Authors: Semnasti Mochammad Tutuk Safirin , Semnasti Mega Cattleya PA Islami , Semnasti Rizqi Novita Sari , Semnasti Aron Lamhot M Panjaitan , Semnasti Annisa Marwadelia
Published: November 2023

Beban kerja fisik mengacu pada aktivitas atau tugas yang memerlukan penggunaan tenaga fisik dan kekuatan tubuh. Perusahaan yang diteliti merupakan sebuah perusahaan pabrikasi jobshop, sheet metal dan pipe metal di Surabaya. Masalah yang berkaitan dengan proses manual yang masih banyak diterapkan di beberapa divisi dan ditambah siste kerja shift yang berdasarkan survey awal, pegawai menganggap shift malam menjadi shift yang paling dihindari. Berdasarkan permasalahan tersebut, maka diperlukan penelitian ini dengan tujuan penelitian mengeatahui beban kerja fisik tiap shift dan pengaruhnya terhadap kelelahan melalui metode Cardiovasculair Load (CVL) dan perhitungan konsumsi energi. Berdasarkan hasil penelitian, maka dapat disimpulkan bahwa %CVL pada shift pagi dan malam masuk dalam kategori tidak terjadi kelelahan, namun demikian meskipun rata-rata menunjukkan tidak terjadi kelelahan, pada perhitungan individu pekerja shift malam bagian cutting, welding atas dan welding bawah memiliki prosentase %CVL lebih tinggi dan masuk dalam kategori diperlukannya perbaikan, Sedangkan pada hasil perhitungan konsumsi energi, seluruh bagian kerja pada shift pagi dan malam, masuk dalam kategori pekerjaan dengan konsumsi energi ringan hingga sangat ringan
Qualitative Evaluation on the Use of Pneumonia Antibiotics for Covid-19 Patients at X Hospital Bali in 2020
Authors: Anggraini Wirda , Fauzia Fitria Rahma , Suryadinata Arief , Ma'arif Burhan , Budayanti Ni Nyoman Sri , Dewi Fransiska Rosari
Published: November 2023

Coronavirus disease-19 (Covid-19) is a pandemic that has caused various complications, including pneumonia. One of the therapies used in Covid-19 with pneumonia complications is antibiotics. Antibiotics must be used appropriately to prevent antibiotic resistance. A method to reduce the number of antibiotic resistances is evaluating the use of antibiotics qualitatively using the Gyssens method. Therefore, this study aims to describe the profile and rationality of using pneumonia antibiotics for adult Covid-19 patients at X Hospital from January to December 2020. The data was collected retrospectively on adult patients using the patient's medical record data, and the sample was determined using the purposive sampling technique. There were 117 samples of medical record data processed in this study. This study concluded that the use of antibiotics for patients with Covid-19 disease consisted of single antibiotic usage, i.e., azithromycin in 82 cases (70.09%), and levofloxacin in 30 cases (25.64%), and switched antibiotics usage, i.e., azithromycin to levofloxacin in 5 cases (4.27%). The rationality of using antibiotics using the Gyssens methods was 90.60% with rational or appropriate antibiotics use (category 0). Moreover, there was 9.40% irrational drug use (category I-VI), comprising antibiotics for a longer time than it should be, in 11 cases.
Fibrinolytic Protease Activity of Crude Enzyme from Fermented Sunflower (Helianthus annuus) and Common Bean (Phaseolus vulgaris) seeds by Rhizopus microsporus var. oligosporus FNCC 6010 in Solid State Fermentation
Authors: Lusiana Rebhika , Poernomo Achmad Toto , Syahrani Achmad
Published: November 2023

In the entire world, cardiovascular diseases (CVDs) are the main cause of death. For the treatment of CVDs, microbial fibrinolytic enzymes are highly regarded as novel therapeutic candidates. This study was purposed to determine the fibrinolytic protease activity produced by fungus source, which is Rhizopus microsporus var. oligosporus FNCC 6010 in fermented sunflower (Helianthus annuus) seed and common bean (Phaseolus vulgaris) seed. Fermentation was carried out by solid-state fermentation method at an initial pH of 5, incubation temperature of 33±1°C, and incubation time of 24 hours. The fermented seed was extracted to obtain supernatant as the crude enzyme. The proteolytic activity assay was done by the skimmed milk agar (SMA) plate method to obtain the proteolytic index, and the fibrinolytic activity assay was conducted by the fibrin-agarose plate method to get the fibrinolytic index. The results show that crude enzymes from fermented H. annuus and P. vulgaris seeds by R. microsporus have fibrinolytic protease activity with proteolytic index 2.64 ± 0.01 and 2.23 ± 0.04, respectively. The fibrinolytic index is 2.40 ± 0.06 and 1.64 ± 0.06, respectively. Therefore, the crude enzyme has the potential to be further researched as a candidate for thrombolytic agents. The purification, characterization, and in-depth research are needed to develop enzymes into preparations for preventing and treating CVDs.
Cancer Detection Rate of MRI Ultrasound Fusion Prostate Biopsy in 1,039 Patients and Number Needed to Biopsy in Targeted Lesion
Authors: Choomark Sivakorn , Aussavavirojekul Pubordee , Woranisarakul Varat , Srinualnad Sittiporn
Published: November 2023

Objective: To determine the cancer detection rate (CDR) of magnetic resonance imaging ultrasound fusion prostate biopsy (MRI/US fusion prostate biopsy) in Thailand. The secondary aim was to estimate the number needed to biopsy (NNB) for each prostate lesion in a targeted biopsy, classified by Prostate Imaging-Reporting and Data System (PI-RADS).
Materials and Methods: The data of 1,039 consecutive patients who underwent a MRI/US fusion prostate biopsy at Siriraj Hospital between September 2017 and February 2021 was included and retrospectively reviewed. Those included had previous negative biopsies and were biopsy naïve. The data was analyzed to find the detection rate and NNB.
Results: The overall detection rate of MRI/US fusion prostate biopsy was 58.71%, whereas that of systematic biopsy was 45.72%. Clinically significant prostate cancer (csPCa) (Gleason score ≥ 3+4) detection rate of MRI/US fusion prostate biopsy was 51.01%. When categorized by PI-RADS category 3, 4, and 5 were 12.16%, 44.98%, 85.71% respectively. NNB in targeted biopsy of PI-RADS 3, 4, and 5 were 8, 7, and 3 times sequentially. Positive predictive factors for prostate cancer (PCa) detection were age, prostate-specific antigen density (PSAD) and PI-RADS, whereas prostate volume was a negative predictive factor.
Conclusion: This study supports the role of MRI/US fusion prostate biopsy in PCa detection and should not avoid systematic biopsies. The higher the PI-RADS was, the greater the csPCa detection rate. NNB is helpful in guiding the least amount of biopsied cores for each lesion.
Organizational Culture and Quality Improvement on Sustainability Performance During the First Year of Covid-19 in the Healthcare Industry
Authors: Morgan Yun-Chen , Zee Susan M. L. , Fok Lillian Y.
Published: November 2023

This research examines employees’ perceptions of green practices implemented in organizations and their impacts on sustainability performance focusing on the healthcare industry during the first year of COVID-19. It explores how organizational culture and quality improvement practices affect the relationship between green practices and sustainability performance. Results indicate a multi-level framework that organizational culture and quality improvement practices significantly affect the relationship between green practices and healthcare organizations’ sustainability performance.
A gap analysis on modelling of sea lice infection pressure from salmonid farms. II. Identifying and ranking knowledge gaps: output of an international workshop
Authors: Murphy JM , Moriarty M , Brooker AJ , Waites W , Revie CW , Adams TP , Lewis M , Reinardy HC , Phelan JP , Coyle JP , Rabe B , Ives SC , Armstrong JD , Sandvik AD , Asplin L , Karlsen Ø , Garnier S , á Norði G , Gillibrand PA , Last KS , Murray AG
Published: November 2023

Sea lice are a major health hazard for farmed Atlantic salmon in Europe, and their impact is felt globally. Given the breadth of ongoing research in sea lice dispersal and population modelling, and focus on research-led adaptive management, we brought experts together to discuss research knowledge gaps. Gaps for salmon lice infection pressure from fish farms were identified and scored by experts in sea lice-aquaculture-environment interactions, at an international workshop in 2021. The contributors included experts based in Scotland, Norway, Ireland, Iceland, Canada, the Faroe Islands, England and Australia, employed by governments, industry, universities and non-government organisations. The workshop focused on knowledge gaps underpinning 5 key stages in salmon lice infection pressure from fish farms: larval production; larval transport and survival; exposure and infestation of new hosts; development and survival of the attached stages; and impact on host populations. A total of 47 research gaps were identified; 5 broad themes emerged with 13 priority research gaps highlighted as important across multiple sectors. The highest-ranking gap called for higher quality and frequency of on-farm lice count data, along with better sharing of information across sectors. We highlight the need for synergistic international collaboration to maximise transferable knowledge. Round table discussions through collaborative workshops provide an important forum for experts to discuss and agree research priorities.
Stem overgeneralizations in the acquisition of Croatian verbal morphology: Evidence from parental questionnaires
Authors: Hržica Gordana , Bošnjak Botica Tomislava , Košutar Sara
Published: November 2023

Studies on verbal overgeneralization often focus on languages with low morphological complexity. The Croatian conjugational system exhibits varying degrees of complexity, and this complexity is not primarily based on the number of inflectional morphemes, but on an elaborate system of stem changes. During early language development, children face the difficult task of acquiring this system, using overgeneralized forms to overcome its complexity. To date, studies have used a corpus-based method to retrieve overgeneralizations in child language, which has had limited success in capturing this phenomenon. The aim of this study was to investigate the production of overgeneralized verb forms in Croatian monolingual children aged 2;6 to 5;11 using a questionnaire in which parents report overgeneralizations used by their children. We tested the relationship between the production of overgeneralized forms and features of the input language (token frequency and class size). We hypothesized that the rate of overgeneralizations will depend on input language features, i.e. a higher rate of overgeneralizations for infrequent verbs and for verbs with smaller class size. The items selected for the questionnaire are the verbs with stem change used by parents in the longitudinal Croatian corpus of child language. Parents report overgeneralized forms in all verb classes, and verb frequency and class size negatively correlate with the proportion of overgeneralizations. Our results show that children gradually abstract morphological systems in a way that is highly sensitive to the properties of the input.
Studying negative evidence in Finnish language corpora
Authors: Nikolaev Alexandre , Bermel Neil
Published: November 2023

This study explores the relationship between lower-than-expected frequencies of word forms and inherent gaps in Finnish inflectional paradigms. The research aims to determine whether it is possible to predict paradigmatic gaps from lower-than-expected frequencies of word forms. We examined Finnish nouns inflected in a marginal case (the instructive) and hypothesized that some of these nouns may potentially have gaps in their inflectional paradigms. However, we found that such gaps are contingent and do not cause uncertainty when filled. We find that the correlation between inherent gaps and lower frequencies is one-directional: predicting inherent gaps from lower-than-expected frequencies is problematic. The results suggest that any paradigmatic gap suggested by corpus frequency is more likely to be contingent than inherent, and that the less semantic need there is for a particular word form, the more likely it will be unattested even in a large corpus. The research highlights the importance of considering semantic profiles when analyzing the grammaticality of word forms and suggests that statistical tests like Fisher’s exact are not necessarily the right approach to tackle the problem of negative evidence in corpus studies.
Exploring the impact of left ventricular diastolic dysfunction on postoperative cardiac surgery outcomes, with a focus on sex disparities: a comprehensive literature review
Authors: Ludden T. , Alberts T. A. M. , Breel J. S. , de Klerk E. S. , Javaid S. K. , Boekholdt S. M. , Hermanides J. , Hermanns H. , Eberl S.
Published: November 2023

Introduction

Left ventricular diastolic dysfunction (LVDD) is known to cause worse outcomes after cardiac surgery. Females have twice the risk of developing LVDD compared with males. The aim of this literature review was to evaluate the association between LVDD and early (≤30 days) outcomes after cardiac surgery, including sex disparities.

Methods

We identified 454 studies in Medline and Embase, of which 19 were included. Articles were assessed for inclusion of female patients with LVDD, ≥50 years of age undergoing cardiac surgery (on or off-pump) or transcatheter aortic valve replacement. The primary outcome was early postoperative mortality. Secondary outcomes were early postoperative complications, ICU length of stay (ICULOS), hospital length of stay (HLOS), and other sex-related postoperative outcomes.

Results

In patients with LVDD, the majority of studies showed that higher LVDD grades correlate with higher early postoperative mortality. In patients with LVDD, who underwent on-pump cardiac surgery, female sex was significantly associated with higher LVDD grades and baseline E/e' ratios. Females with LVDD, were associated with prolonged HLOS after off-pump coronary artery bypass grafting (CABG). In combined cardiac surgery, a twofold increased risk of prolonged HLOS and increased ICULOS was reported. Furthermore, increased left ventricular end-diastolic filling pressure, an increased need for postoperative inotropic support, and difficult separation from cardiopulmonary bypass were observed.

Discussion

Despite the limited number of studies focusing on sex differences, females with LVDD appear to have worse early outcomes after cardiac surgery compared to men with LVDD. Future research will need to identify sex-specific risk factors and target treatment optimization.
Case Report: Coronaro-bronchial fistula vascularizing a squamous cell lung cancer
Authors: Ntshaykolo Chloe , Fave Thomas , Benic Clement , Boizet Antoine , Geier Margaux , Nicol Pierre-Philippe , Descourt Renaud
Published: November 2023

Coronary fistulas are rare, having been described for the first time by Krauss in 1865 in postmortem. They are commonly asymptomatic and can be caused by congenital or acquired malformations. We present the case of a 65-year-old patient who was treated for squamous cell lung cancer with chemoimmunotherapy and presented with angina. The coronary angiography showed a coronaro-bronchial fistula that arises from a branch of the right coronary artery and is associated with lung cancer.
Your robot therapist is not your therapist: understanding the role of AI-powered mental health chatbots
Authors: Khawaja Zoha , Bélisle-Pipon Jean-Christophe
Published: November 2023

Artificial intelligence (AI)-powered chatbots have the potential to substantially increase access to affordable and effective mental health services by supplementing the work of clinicians. Their 24/7 availability and accessibility through a mobile phone allow individuals to obtain help whenever and wherever needed, overcoming financial and logistical barriers. Although psychological AI chatbots have the ability to make significant improvements in providing mental health care services, they do not come without ethical and technical challenges. Some major concerns include providing inadequate or harmful support, exploiting vulnerable populations, and potentially producing discriminatory advice due to algorithmic bias. However, it is not always obvious for users to fully understand the nature of the relationship they have with chatbots. There can be significant misunderstandings about the exact purpose of the chatbot, particularly in terms of care expectations, ability to adapt to the particularities of users and responsiveness in terms of the needs and resources/treatments that can be offered. Hence, it is imperative that users are aware of the limited therapeutic relationship they can enjoy when interacting with mental health chatbots. Ignorance or misunderstanding of such limitations or of the role of psychological AI chatbots may lead to a therapeutic misconception (TM) where the user would underestimate the restrictions of such technologies and overestimate their ability to provide actual therapeutic support and guidance. TM raises major ethical concerns that can exacerbate one's mental health contributing to the global mental health crisis. This paper will explore the various ways in which TM can occur particularly through inaccurate marketing of these chatbots, forming a digital therapeutic alliance with them, receiving harmful advice due to bias in the design and algorithm, and the chatbots inability to foster autonomy with patients.
Colored noise in river level oscillations as triggering factor for unstable dynamics in a landslide model with displacement delay
Authors: Kostić Srđan , Stojković Milan
Published: November 2023

In the present paper we examine the effect of the noise in river level oscillation on the landslide dynamics. The analysis is conducted in several phases. In the first phase, we analyze the multi-annual level oscillation of the Kolubara and the Ibar river (Serbia). Based on the observed dataset, we suggest a deterministic model for the river level oscillation with the additional contribution of the noise part, which we confirm to have the properties of colored noise. In the second phase of the research, we introduce the influence of the river-level oscillation, with the included effect of colored noise in the spring-block delay model of landslide dynamics. Results of the research indicate conditions under which the effect of river noise has both stabilizing and destabilizing effects on the landslide dynamics. The effect of noise intensity D and correlation time ε is systematically analyzed in interaction with delayed interaction, spring stiffness and friction parameters. It is determined that the landslide dynamics is sensitive to the change of noise intensity and that the increase of noise intensity leads to onset of unstable landslide dynamics. On the other hand, results obtained indicate that the examined model of landslide dynamics is rather robust towards the change of correlation time ε. Interaction of this parameter and some of the friction parameters leads to stabilization of landslide dynamics, which confirms the importance of the influence of the noise color in river level oscillations on the landslide dynamics.
Identification of the key immune-related genes and immune cell infiltration changes in renal interstitial fibrosis
Authors: Dong Zhitao , Chen Fangzhi , Peng Shuang , Liu Xiongfei , Liu Xingyang , Guo Lizhe , Wang E. , Chen Xiang
Published: November 2023

Background

Chronic kidney disease (CKD) is the third-leading cause of premature mortality worldwide. It is characterized by rapid deterioration due to renal interstitial fibrosis (RIF) via excessive inflammatory infiltration. The aim of this study was to discover key immune-related genes (IRGs) to provide valuable insights and therapeutic targets for RIF in CKD.

Materials and methods

We screened differentially expressed genes (DEGs) between RIF samples from CKD patients and healthy controls from a public database. Least absolute shrinkage and selection operator regression analysis and receiver operating characteristic curve analysis were applied to identify significant key biomarkers. The single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm was used to analyze the infiltration of immune cells between the RIF and control samples. The correlation between biomarkers and immune cell composition was assessed.

Results

A total of 928 DEGs between CKD and control samples from six microarray datasets were found, 17 overlapping immune-correlated DEGs were identified by integration with the ImmPort database, and six IRGs were finally identified in the model: apolipoprotein H (APOH), epidermal growth factor (EGF), lactotransferrin (LTF), lysozyme (LYZ), phospholipid transfer protein (PLTP), and secretory leukocyte peptidase inhibitor (SLPI). Two additional datasets and in vivo experiments indicated that the expression levels of APOH and EGF in the fibrosis group were significantly lower than those in the control group, while the expression levels of LTF, LYZ, PLTP, and SLPI were higher (all P < 0.05). These IRGs also showed a significant correlation with renal function impairment. Moreover, four upregulated IRGs were positively associated with various T cell populations, which were enriched in RIF tissues, whereas two downregulated IRGs had opposite results. Several signaling pathways, such as the “T cell receptor signaling pathway” and “positive regulation of NF-κB signaling pathway”, were discovered to be associated not only with immune cell infiltration, but also with the expression levels of six IRGs.

Conclusion

In summary, six IRGs were identified as key biomarkers for RIF, and exhibited a strong correlation with various T cells and with the NF-κB signaling pathway. All these IRGs and their signaling pathways may evolve as valuable therapeutic targets for RIF in CKD.
The weight-adjusted-waist index and cognitive impairment among U.S. older adults: a population-based study
Authors: Huang Xiao-tong , Lv Xiang , Jiang Hong
Published: November 2023

Objectives

Multiple research projects have provided evidence of the correlation between obesity and cognitive impairment. WWI, a novel metric for assessing obesity, has the potential to provide a more precise assessment of muscle and fat mass. This research aimed to investigate the association between WWI and cognitive functioning among elderly individuals residing in the United States.

Methods

This study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2014. Weighted multiple linear regression models, smoothed fitted curves, and generalized weighted models were employed to examine the associations between WWI and cognitive function in linear and nonlinear contexts.

Results

The study included a cohort of 2,764 adult volunteers aged 60 years and older, all with complete data. Upon controlling for all potential confounding variables, our analysis revealed statistically significant negative associations between WWI and the Digit Symbol Substitution Test (DSST) score. Specifically, for each 1-unit increase in WWI, there was a corresponding loss of 3.57 points in the DSST score [-3.57 (-4.31, -2.82)]. The negative correlations between WWI with CERAD total word recall [-0.63 (-0.85, -0.40)], CERAD delayed recall [-0.19 (-0.30, -0.07)], and AFT [-0.65 (-0.94, -0.37)] were significant only in partially adjusted models.

Conclusion

Higher WWI was associated with poorer cognitive function.
Spatio-temporal load migration potential of data centers: Evaluation and application
Authors: Zhu Lei , Wu Shutan , Liu Haoyu , Wang Qi , Tang Yi
Published: November 2023

The wide distribution of data centers and the delay tolerance of computing tasks endow data center loads with adjustable characteristics in both temporal and spatial dimensions. Due to the characteristics of abundant spatiotemporal flexibility, data centers can participate in the optimization of power system operation and regulation. To quantify this flexibility, this paper proposes a spatiotemporal load migration potential evaluation model. Meanwhile, a data center energy management strategy is combined with the characteristics of spatiotemporal load migration, which deeply exploits the migration potential through the spatiotemporal redistribution of delay-tolerant tasks, as well as server ON/OFF scheduling and CPU operating frequency scaling across different spatial locations. A case study demonstrates that adopting the proposed approach considering an energy management strategy can effectively improve the load migration potential of data centers. The migration characteristics of data centers have great application prospects in reducing carbon emissions and enhancing operational flexibility.
Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts
Authors: Gonzalez Dias Carvalho Patrícia Conceição , Dominguez Crespo Hirata Thiago , Mano Alves Leandro Yukio , Moscardini Isabelle Franco , do Nascimento Ana Paula Barbosa , Costa-Martins André G. , Sorgi Sara , Harandi Ali M. , Ferreira Daniela M. , Vianello Eleonora , Haks Mariëlle C. , Ottenhoff Tom H. M. , Santoro Francesco , Martinez-Murillo Paola , Huttner Angela , Siegrist Claire-Anne , Medaglini Donata , Nakaya Helder I.
Published: November 2023

Introduction

The rVSVDG-ZEBOV-GP (Ervebo®) vaccine is both immunogenic and protective against Ebola. However, the vaccine can cause a broad range of transient adverse reactions, from headache to arthritis. Identifying baseline reactogenicity signatures can advance personalized vaccinology and increase our understanding of the molecular factors associated with such adverse events.

Methods

In this study, we developed a machine learning approach to integrate prevaccination gene expression data with adverse events that occurred within 14 days post-vaccination.

Results and Discussion

We analyzed the expression of 144 genes across 343 blood samples collected from participants of 4 phase I clinical trial cohorts: Switzerland, USA, Gabon, and Kenya. Our machine learning approach revealed 22 key genes associated with adverse events such as local reactions, fatigue, headache, myalgia, fever, chills, arthralgia, nausea, and arthritis, providing insights into potential biological mechanisms linked to vaccine reactogenicity.
No causal effect of genetically determined circulating homocysteine levels on psoriasis in the European population: evidence from a Mendelian randomization study
Authors: Chen Chaojian , Liu Shuo , Liu Junhao , Zheng Ziqi , Zheng Yixi , Lin Zhongliang , Liu Yuchun
Published: November 2023

Background

Although numerous studies demonstrated a link between plasma homocysteine (Hcy) levels and psoriasis, there still exists a certain level of controversy. Therefore, we conducted a Mendelian randomization study to investigate whether homocysteine plays a causative role in the development or exacerbation of psoriasis.

Methods

A two-sample Mendelian randomization (MR) analysis was conducted. Summary-level data for psoriasis were acquired from the latest R9 release results from the FinnGen consortium (9,267 cases and 364,071 controls). Single nucleotide polymorphisms (SNPs) robustly linked with plasma Hcy levels at the genome-wide significance threshold (p < 5 × 10−8) (18 SNPs) were recognized from the genome-wide meta-analysis on total Hcy concentrations (n = 44,147 participants) in individuals of European ancestry. MR analyses were performed utilizing the random-effect inverse variance-weighted (IVW), weighted median, and MR-Egger regression methods to estimate the associations between the ultimately filtrated SNPs and psoriasis. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy.

Results

MR analyses revealed no causal effects of plasma Hcy levels on psoriasis [IVW: odds ratio (OR) = 0.995 (0.863–1.146), p = 0.941; weighed median method: OR = 0.985 (0.834–1.164), p = 0.862; MR-Egger regression method: OR = 0.959 (0.704–1.305), p = 0.795]. The sensitivity analyses displayed no evidence of heterogeneity and directional pleiotropy, and the causal estimates of Hcy levels were not influenced by any individual SNP.

Conclusion

Our study findings did not demonstrate a causal effect of genetically determined circulating Hcy levels on psoriasis.
Plastitar records in marine coastal environments worldwide from 1973 to 2023
Authors: Ellrich Julius A. , Ehlers Sonja M. , Furukuma Shunji
Published: November 2023

Plastics embedded in tar residues encrusting rocky coastlines were discovered on the Canary Islands (NE Atlantic Ocean) and termed “plastitar” in 2022. As plastic and tar pollution is widespread in marine pelagic and benthic habitats, it was predicted that this novel plastic form could occur on other coasts as well. To test this prediction, we reviewed the literature on plastic embedded in tar and examined rocky coastlines in our regions for plastitar. We found eight studies which reported plastic embedded in tar under several descriptions and terms (including “tar-bonded beach-conglomerate tarcrete”, “plasto-tar crust”, “plasto-tarball” and “plastitar”) in India (Arabian Sea), Bermuda (Saragossa Sea), the Bahamas (NW Atlantic Ocean), the United Arabic Emirates (Arabian Gulf and Gulf of Oman), Malta (central Mediterranean Sea), Croatia (Adriatic Sea), Italy (Adriatic and Ligurian Sea), Cabrera island, Menorca island and Sardinia island (western Mediterranean Sea) and Indonesia (Java Sea) from 1973 to 2023. We also detected plastitar during our field surveys in Japan (Sea of Japan) and Mallorca island (western Mediterranean Sea) in 2022 and 2023, respectively. Using Fourier-transform infrared spectroscopy (FTIR), we verified the contained plastics as polyethylene (PE). Pyrolysis-gas chromatography-mass spectrometry (PY-GC/MS) indicated that the tar residues derived from crude oil. Furthermore, plotting all these plastitar records in a global map revealed that almost all plastitar findings were made along the major oil transportation routes across the northern hemisphere suggesting that plastitar resulted from tanker-released crude oils. Overall, our study shows, for the first time, that plastitar has been a widespread and long overlooked plastic form in coastal systems worldwide.
Diagnostic and prognostic values of conjunctival and oral biopsies analyzed by direct immunofluorescence in patients with mucous membrane pemphigoid
Authors: Jakubowska Beata , Pietrzyk Ewelina , Maciejewicz Piotr , Kowalewski Cezary , Wozniak Katarzyna
Published: November 2023

Introduction

Mucous membrane pemphigoid (MMP) is diagnosed on the basis of a characteristic clinical picture (a predilection for mucosal involvement and scarring in the affected tissues) and a positive direct immunofluorescence (DIF) result.

Methods

In this study, we compare the diagnostic and prognostic values of conjunctival and oral biopsies analyzed by DIF in patients with MMP. Sixteen patients with MMP and mucosal involvement as a predominant symptom were classified into three groups based on the clinical picture. Oral and conjunctival DIF were performed on all patients.

Results

Our study showed that patients with simultaneous oral and conjunctival involvement had a positive oral DIF in 83% and a positive ocular DIF in 100% of the examined cases, respectively. Patients with isolated ocular MMP had a positive oral DIF in 50% and a positive ocular DIF in 66% of the examined cases, respectively. Patients with only oral involvement with MMP had a positive oral DIF in 100% and a positive ocular DIF in 50% of the examined cases, respectively.

Discussion

Oral biopsy should be performed first and is usually sufficient for the diagnosis, even in patients with exclusively ocular MMP, whereas in patients without clinical ocular involvement, ocular DIF is positive in half of the cases and may be a predictive factor for ocular lesions in the future.