bluuebunny/crossref_metadata_2025 huggingface dataset:
Vertical Greenery as Natural Tool for Improving Energy Efficiency of Buildings
Authors: Campiotti Carlo Alberto , Gatti Lorenzo , Campiotti Alessandro , Consorti Luciano , De Rossi Patrizia , Bibbiani Carlo , Muleo Rosario , Latini Arianna
Published: June 2022

The European Construction Sector Observatory outlined that green building envelopes as green roofs and walls contribute to the reduction of energy demand and CO2 emissions due to the air conditioning in summer periods, and the mitigation of heat islands in urban areas. For this reason, the understanding about the contribution of urban greening infrastructures on buildings to sustainable energy use for air conditioning is urgent. This paper focuses on the analysis of a vertical surface provided with a Parthenocissus quinquefolia (L.) Planch., a winter deciduous species, as green cover of a building, assessing the reduction of the solar radiation energy absorbed by the façade and, consequently, the heat flux (HF) transmitted into the internal ambient. This research shows that, in July, surface temperatures (STs) on the vegetated façade were up to 13 °C lower than on the unvegetated (bare) façade. Under the climate and environmental conditions of the green wall located at ENEA Casaccia Research Center, a saving of 2.22 and 1.94 kWhe/m2, respectively in 2019 and 2020, for the summer cooling electricity load, was achieved. These energy reductions also allowed the saving of 985 and 862 g CO2/m2 emissions, respectively, in 2019 and 2020. Ultimately, a green factor named Kv* was also elaborated to evaluate the influence of vegetation on the STs as well as on HFs transmitted into the indoor ambient and adapted to the case of a detached vertical green cover. Measurements of Kv* factor lasting three years showed the suitability of this index for defining the shading capacity of the vegetation on the building façade surfaces, which can be used to predict thermal gains and effects in a building endowed of a vertical green system.
Evolution of Oleuropein and Other Bioactive Compounds in Arbequina Olive Leaves under Different Agronomic Conditions
Authors: Martínez-Navarro María Esther , Cebrián-Tarancón Cristina , Salinas María Rosario , Alonso Gonzalo L.
Published: June 2022

Oleuropein and other phenolic compounds contained in olive leaves give it the potential to be transformed from residue to co-product in an oil mill. However, the moment of the agronomic cycle in which their potential transformation is higher is not known in detail. Therefore, for the first time, a monthly study of the evolution of such compounds throughout an agronomic cycle is made (November 2019 to October 2020). Arbequina olive leaves were collected from three plots and the interactive effects of agronomic conditions were investigated, such as crop management (conventional and ecological), plantation framework (intensive and super-intensive) and location under different climatic conditions. The results showed that the main compound throughout the cycle was oleuropein and the highest levels occurred around the pruning season (February/March). Crop management and location affected the content of verbascoside and hydroxytyrosol, while plantation framework only influenced the flavonoid content. All compounds were affected by relative humidity and differential temperature, although hydroxytyrosol showed the highest correlation with the maximum temperature. The absorbance measurements by ultraviolet-visible spectrophotometry showed trends parallel to the oleuropein concentration measured by high-performance liquid chromatography, which suggests that this method could be useful to easily study the evolution of oleuropein in the oil mill.
Is Greenhouse Rainwater Harvesting Enough to Satisfy the Water Demand of Indoor Crops? Application to the Bolivian Altiplano
Authors: Sayol Juan-Manuel , Azeñas Veriozka , Quezada Carlos E. , Vigo Isabel , Benavides López Jean-Paul
Published: June 2022

As many other regions worldwide, the Bolivian Altiplano has to cope with water scarcity during dry periods, which in turn impacts on crop production as flood irrigation is overwhelmingly extended in the region. Since farming is the main income in the Altiplano for most families, the availability of greenhouses with water harvesting systems may represent a solution to warrant all year round production and food access. We study the daily satisfied water demand from a balance between rainfall collected by a greenhouse roof and water used for indoor crop irrigation assuming a tank is available for water storage. This balance is analyzed for 25 greenhouses spread over Batallas Municipality, close to Titicaca Lake, Bolivia, and for two case studies: (i) using irrigation data collected from farmers in the frame of a regional project; (ii) using theoretical daily water requirements assuming an intense greenhouse farming. Our evaluation includes a sensitivity analysis of relevant parameters, such as the influence of the time window of rainfall used in the simulation, the runoff coefficient, the roof surface area, the irrigation drip system, the irrigation frequency, the crop coefficient, the volume of water used for crop irrigation, and the capacity of the water tank. Overall, we find that the runoff coefficient has little impact on the satisfied demand rate, while all other parameters can play an important role depending on the greenhouse considered. Some greenhouses are able to irrigate crops normally during the wet season, while during the dry season, greenhouses are not able to satisfy more than 50% of the theoretical water requirements, even when large tanks are considered. Based on these results, we recommend the construction of greenhouses with a ground surface of <50 m2 attached to the largest available covered water tank. The information here provided can be used by stakeholders to decide their policies of investment in infrastructures in the Altiplano. Finally, the approach we follow can be applied to any other region where rainfall, temperature, and greenhouse data are available.
Effects of Water and Fertilizer Management Practices on Methane Emissions from Paddy Soils: Synthesis and Perspective
Authors: Gu Xinyun , Weng Shimei , Li Yu’e , Zhou Xiaoqi
Published: June 2022

Water and fertilizer management practices are considered to have great influence on soil methane (CH4) emissions from paddy fields. However, few studies have conducted a quantitative analysis of the effects of these management practices. Here, we selected 156 observations of water management from 34 articles and 288 observations of fertilizer management from 37 articles and conducted a global meta-analysis of the effects of water and fertilizer management practices on soil CH4 emissions in paddy fields. In general, compared with traditional irrigation (long-term flooding irrigation), water-saving irrigation significantly decreased soil CH4 emissions but increased rice yield. Among the different practices, intermittent irrigation had the fewest reductions in CH4 emissions but the greatest increase in rice yield. In addition, fertilization management practices such as manure, mixed fertilizer (mixture), and straw significantly enhanced CH4 emissions. Rice yields were increased under fertilization with a mixture, traditional fertilizer, and controlled release fertilizer. Our results highlight that suitable agricultural water and fertilizer management practices are needed to effectively reduce CH4 emissions while maintaining rice yields. We also put forward some prospects for mitigating soil CH4 emissions from paddy fields in the context of global warming in the future.
Laboratory Chamber Evaluation of Flow Air Quality Sensor PM2.5 and PM10 Measurements
Authors: Crnosija Natalie , Levy Zamora Misti , Rule Ana M. , Payne-Sturges Devon
Published: June 2022

The emergence of low-cost air quality sensors as viable tools for the monitoring of air quality at population and individual levels necessitates the evaluation of these instruments. The Flow air quality tracker, a product of Plume Labs, is one such sensor. To evaluate these sensors, we assessed 34 of them in a controlled laboratory setting by exposing them to PM10 and PM2.5 and compared the response with Plantower A003 measurements. The overall coefficient of determination (R2) of measured PM2.5 was 0.76 and of PM10 it was 0.73, but the Flows’ accuracy improved after each introduction of incense. Overall, these findings suggest that the Flow can be a useful air quality monitoring tool in air pollution areas with higher concentrations, when incorporated into other monitoring frameworks and when used in aggregate. The broader environmental implications of this work are that it is possible for individuals and groups to monitor their individual exposure to particulate matter pollution.
Assessment of the Level of Satisfaction with Medical Care of Patients Treated in Osteoporosis Clinics as an Indicator of the Quality of Medical Care
Authors: Barańska Agnieszka , Religioni Urszula , Drop Bartłomiej , Bogdan Magdalena , Kłak Anna , Warunek Andrzej , Herda Jolanta , Firlej Ewelina , Merks Piotr
Published: June 2022

The aims of this research are to assess the level of satisfaction with medical care among patients treated in osteoporosis clinics and to determine the relationship among the frequency of visits to the doctor, the duration of treatment, socio-demographic factors, and patient satisfaction with the medical care they receive. The study was conducted from August 2016 to July 2018 at osteoporosis clinics in eastern Poland. The study participants were 312 patients treated for osteopenia or osteoporosis. The authors utilized two research instruments: the PASAT POZ questionnaire and their own questionnaire. The results indicate that the duration of osteoporosis treatment is a factor that significantly influences the level of satisfaction with medical care: the longer the treatment time, the poorer the assessment of the clinic, and therefore, the lower the patient degree of satisfaction. Our analysis shows that women assess clinics more positively overall. Additionally, the higher the study participants’ age, the lower the general assessment of the clinic. A further analysis showed that respondents in better financial situations and with higher levels of education tended to assess clinics more favorably. The Pareto-Lorenz analysis indicated that the key element in general assessments of specialist clinics is the doctor. It is advisable for health service providers to monitor the quality of health care they are providing and make improvements. Therefore, further research is needed, especially in relation to chronic diseases such as osteoporosis.
Focal Mechanism and Source Parameters Analysis of Mining-Induced Earthquakes Based on Relative Moment Tensor Inversion
Authors: Cao Anye , Liu Yaoqi , Chen Fan , Hao Qi , Yang Xu , Wang Changbin , Bai Xianxi
Published: June 2022

Mining-induced earthquakes (MIEs) in underground coal mines have been a common phenomenon that easily triggers rock bursts, but the mechanism is not understood clearly. This research investigates the laws of focal mechanism and source parameters based on focal mechanism and source parameters analysis of MIEs in three frequent rock burst areas. The relative moment tensor inversion (MTI) method was introduced, and the way to construct the inversion matrix was modified. The minimum ray and source number conditions were calculated, and an optimized identification criterion for source rupture type was proposed. Results show that the geological structure, stress environment, and source horizon influence the focal mechanism. The tensile type sources can distribute in the roof and coal seam, while the shear types are primarily located in the coal seam. In the typical fold structure area, the difference in source rupture strength and stress adjustment between tensile and shear types is negligible, while the disturbance scale of tensile types is distinct. The shear types have higher apparent volume and seismic moment in the deep buried fault area but lower source energy. The apparent stress of the tensile types is higher than that of the shear types, representing that the stress concentration still exists in the roof after the MIEs, but the stress near the faults could be effectively released. In the high-stress roadway pillar area, the primary fracture of the coal pillar easily produces a continuous shear rupture along the dominant stress direction under the extrusion of the roof and floor. The source parameters (except apparent stress) of shear types are higher than tensile types and have higher dynamic risk. The results contribute to expanding the understanding of rock burst mechanisms and guide MIEs’ prevention.
Application of the Balance Model in the Analysis of Factors Responsible for Depressive Disorders among Women in the COVID-19 Pandemic
Authors: Dobiała Ewa , Gulczyńska Anna , Małecki Rafał , Efremova Polina , Ławicka Joanna , Karmolińska-Jagodzik Ewa , Kirillov Ivan
Published: June 2022

The COVID-19 pandemic has significantly affected the lives and mental health of people around the world, and it has become clinically essential to define risk factors in order to provide adequate prevention and support. The aim of the study was to describe coping strategies in Polish women related to the COVID-19 pandemic using the balance model, one of the most important concepts of positive psychotherapy (PPT after Peseschkian since 1977). The analysis included 735 women at the mean age of 39.61 years. The survey was conducted using the questionnaire form on the website. Based on Beck’s depression test, depressive disorders were disclosed in 32.65%, and both the presence and severity of depressive syndromes were inversely correlated with age. Using a cluster analysis, three adaptation strategies could be identified, related to the different prevalence of depressive disorders. Relationships proved the most crucial area of the balance model, responsible for the effectiveness of the coping strategy. Based on the obtained results, it has to be concluded that preventive measures should primarily concern women aged < 25 years old and focus on strengthening the relationships area.
Analysis of the Dilemma of Promoting Circular Logistics Packaging in China: A Stochastic Evolutionary Game-Based Approach
Authors: Xu Xinyang , Yang Yang
Published: June 2022

The environmental pollution caused by logistics packaging in China has attracted increasing attention in recent years, and circular packaging is considered an effective means to solve the aforementioned problem. Therefore, this study considers the uncertainty of the external environment; constructs a stochastic game model of circular logistics-packaging promotion, which consists of environmental regulators, logistics enterprises, and consumers; collects data related to logistics packaging in China to describe the current circular-packaging promotion dilemma; and conducts a parameter-sensitivity analysis. The results show that (1) after a short period of fluctuation, the environmental regulator will lock in the “strong regulation” strategy, whereas logistics enterprises and consumers will quickly lock in the “no promotion” and “negative use” strategies. (2) The change in the initial probability will affect the rate of strategy evolution of the gaming system. (3) The “strong regulatory” strategy of environmental regulators and the increase in the number of circular-packaging cycles can help establish a logistics-recycling-packaging system. (4) The increase in recycling incentives can cause consumers to shift toward “active use” strategies, but this has accelerated the rate at which logistics companies lock into “no promotion” strategies. (5) The increase in the intensity of random interference will raise the fluctuation of the evolution of the game subject. For logistics enterprises, moderate random interference helps them evolve toward the “promotion” strategy.
Cyberbullying and Associated Factors in Member Countries of the European Union: A Systematic Review and Meta-Analysis of Studies with Representative Population Samples
Authors: Henares-Montiel Jesús , Benítez-Hidalgo Vivian , Ruiz-Pérez Isabel , Pastor-Moreno Guadalupe , Rodríguez-Barranco Miguel
Published: June 2022

The aim of this study is to conduct a systematic review and meta-analysis to summarise the current state of empirical research and establish an up-to-date estimate of the prevalence of cyberbullying through the gathering of self-reported experiences from representative population samples from EU countries. Bibliographic searches were conducted on main electronic databases for studies until November 2021. We considered observational studies that provided data on cyberbullying prevalence and/or associated factors. Seven studies with data from 25 countries were included. Rates ranged between 2.8–31.5% for cybervictimization, between 3.0–30.6% for cyberperpetration, and between 13.0–53.1% for cyberbystanding. The rate of cybervictimization perpetration was 4%. Meta-analysis-pooled prevalence showed rates of 9.62% and 11.91% for cybervictimization and cyberperpetration, respectively. Given the large variation in the rates seen between the different examined studies, in addition to the increase over recent years in the prevalence rates of the different examined dimensions of cyberbullying, it would be useful to deepen research into the causes of these differences and the factors associated with each of the dimensions. This should be performed through populational surveys which enable the collection of a greater quantity of more consistent information with a view to designing prevention and intervention CB programs that are targeted and adapted towards the characteristics of the target population.
Physical Activity and Its Barriers and Facilitators among University Students in Qatar: A Cross-Sectional Study
Authors: Chaabna Karima , Mamtani Ravinder , Abraham Amit , Maisonneuve Patrick , Lowenfels Albert B. , Cheema Sohaila
Published: June 2022

Physical inactivity is a leading risk factor for non-communicable diseases worldwide. This study investigated physical activity (PA) level among university students in Qatar and assessed other lifestyle and demographic factors associated with PA. A cross-sectional study was conducted between February 2017 and February 2018. A self-administered questionnaire, comprising questions from the International Physical Activity Questionnaire and other validated questionnaires, was used to assess PA and other lifestyle behaviors, including sedentary behavior, stress, sleep, dietary habits, and smoking habits. The results were reported according to the STROBE guidelines. A total of 370 students (response rate = 95.6%) were recruited from eight universities via quota sampling. The prevalence of physically active students—as per the World Health Organization’s recommendation for PA of 150–300 min/week—was 64.9% (75.2% in males and 58.3% in females). Females and students >20 years old were half as likely to be active compared with males and younger students. More males enjoyed getting regular exercise (83.6% vs. 67.7%, p-value = 0.002). Time spent sitting was similar during weekdays and weekends (mean time ± SD = 480.8 ± 277.7 min/week vs. 492.1 ± 265.0 min/week). Sports facilities and green spaces appear to help increase PA among university students in Qatar. Public health interventions should focus on improving PA-related perception and knowledge among students to further increase PA participation.
Factors Associated with Anemia among Adults and the Elderly Family Farmers
Authors: Lopes Sílvia Oliveira , Ribeiro Sarah Aparecida Vieira , Morais Dayane de Castro , Miguel Elizangela da Silva , Gusmão Laís Silveira , Franceschini Sylvia do Carmo Castro , Priore Silvia Eloiza
Published: June 2022

The majority of studies on anemia are focused on children and women of reproductive age. Although the disease is a widespread public health problem, studies that include the rural population are scarce. This study determined the prevalence of anemia and associated factors in adults and the elderly living in the rural area of a municipality in Minas Gerais. Twelve rural communities were included. During home visits, hemoglobin levels were measured using a hemoglobinometer to check for the presence or absence of anemia. Additionally, anthropometric data and food insecurity data based on the Brazilian Food Insecurity Scale (EBIA) were collected. A questionnaire about socioeconomic, demographic, and housing conditions was applied. Analyses were performed using the Stata software version 13.0. Spearman correlation and regression analysis logistics were performed (p < 0.05) on 124 families (n = 297 farmers). The prevalence of anemia was 41.1%, being higher among women (55.7%). Additionally, 40.1% of the farmers were food insecure; 52.7% and 80.5% presented excess weight and cardiovascular risk, respectively. Poverty was a reality for 39.7% of individuals. A positive correlation between hemoglobin levels and per capita income was found as well as a negative correlation with EBIA scores and cardiovascular risk. Multivariate analysis showed that individuals experiencing food insecurity, the elderly, and those who do not own a property, were more likely to be anemic. Farmers with per capita income above 1/2 minimum wage were less likely to have anemia. The prevalence of anemia in the group studied was higher than previous studies. The disease is associated with factors that also predispose to food insecurity. The improvement of the determinants of insecurity can contribute to the fight against anemia.
Immunotherapy as a Therapeutic Strategy for Gastrointestinal Cancer—Current Treatment Options and Future Perspectives
Authors: Koustas Evangelos , Trifylli Eleni-Myrto , Sarantis Panagiotis , Papadopoulos Nikolaos , Karapedi Eleni , Aloizos Georgios , Damaskos Christos , Garmpis Nikolaos , Garmpi Anna , Papavassiliou Kostas A. , Karamouzis Michalis V. , Papavassiliou Athanasios G.
Published: June 2022

Gastrointestinal (GI) cancer constitutes a highly lethal entity among malignancies in the last decades and is still a major challenge for cancer therapeutic options. Despite the current combinational treatment strategies, including chemotherapy, surgery, radiotherapy, and targeted therapies, the survival rates remain notably low for patients with advanced disease. A better knowledge of the molecular mechanisms that influence tumor progression and the development of optimal therapeutic strategies for GI malignancies are urgently needed. Currently, the development and the assessment of the efficacy of immunotherapeutic agents in GI cancer are in the spotlight of several clinical trials. Thus, several new modalities and combinational treatments with other anti-neoplastic agents have been identified and evaluated for their efficiency in cancer management, including immune checkpoint inhibitors, adoptive cell transfer, chimeric antigen receptor (CAR)-T cell therapy, cancer vaccines, and/or combinations thereof. Understanding the interrelation among the tumor microenvironment, cancer progression, and immune resistance is pivotal for the optimal therapeutic management of all gastrointestinal solid tumors. This review will shed light on the recent advances and future directions of immunotherapy for malignant tumors of the GI system.
The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
Authors: Zhang Linlin , Qi Jingyi , Zhang Xu , Zhao Xiya , An Peng , Luo Yongting , Luo Junjie
Published: June 2022

Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca2+ is not only an important messenger for cell proliferation, but it is also an indispensable signal for cell death. Ca2+ participates in and plays a crucial role in the energy metabolism, physiology, and pathology of mitochondria. Mitochondria control the uptake and release of Ca2+ through channels/transporters, such as the mitochondrial calcium uniporter (MCU), and influence the concentration of Ca2+ in both mitochondria and cytoplasm, thereby regulating cellular Ca2+ homeostasis. Mitochondrial Ca2+ transport-related processes are involved in important biological processes of tumor cells including proliferation, metabolism, and apoptosis. In particular, MCU and its regulatory proteins represent a new era in the study of MCU-mediated mitochondrial Ca2+ homeostasis in tumors. Through an in-depth analysis of the close correlation between mitochondrial Ca2+ and energy metabolism, autophagy, and apoptosis of tumor cells, we can provide a valuable reference for further understanding of how mitochondrial Ca2+ regulation helps diagnosis and therapy.
Plasma Promotes Fungal Cellulase Production by Regulating the Levels of Intracellular NO and Ca2+
Authors: Yu Nan-Nan , Ketya Wirinthip , Choi Eun-Ha , Park Gyungsoon
Published: June 2022

For the industrial-scale production of useful enzymes by microorganisms, technological development is required for overcoming a technical bottleneck represented by poor efficiency in the induction of enzyme gene expression and secretion. In this study, we evaluated the potential of a non-thermal atmospheric pressure plasma jet to improve the production efficiency of cellulolytic enzymes in Neurospora crassa, a filamentous fungus. The total activity of cellulolytic enzymes and protein concentration were significantly increased (1.1~1.2 times) in media containing Avicel 24–72 h after 2 and 5 min of plasma treatment. The mRNA levels of four cellulolytic enzymes in fungal hyphae grown in media with Avicel were significantly increased (1.3~17 times) 2–4 h after a 5 min of plasma treatment. The levels of intracellular NO and Ca2+ were increased in plasma-treated fungal hyphae grown in Avicel media after 48 h, and the removal of intracellular NO decreased the activity of cellulolytic enzymes in media and the level of vesicles in fungal hyphae. Our data suggest that plasma treatment can promote the transcription and secretion of cellulolytic enzymes into the culture media in the presence of Avicel (induction condition) by enhancing the intracellular level of NO and Ca2+.
Galunisertib Exerts Antifibrotic Effects on TGF-β-Induced Fibroproliferative Dermal Fibroblasts
Authors: Peterson Joshua M. , Jay Jayson W. , Wang Ye , Joglar Alejandro A. , Prasai Anesh , Palackic Alen , Wolf Steven E. , El Ayadi Amina
Published: June 2022

Dermal fibroblasts in pathological scars secrete constitutively elevated levels of TGF-β, signaling the transcription of fibrotic genes via activin-like kinase 5 (ALK5). In the present study, we examine the antifibrotic effects of galunisertib, a small-molecule inhibitor of ALK5, on fibroproliferative dermal fibroblasts in an in vitro model of wound healing. We induced fibrosis in human dermal fibroblasts with exogenous TGF-β and performed cellular proliferation assays after treatment with varying concentrations of galunisertib. Dermal fibroblast proliferation was diminished to homeostatic levels without cytotoxicity at concentrations as high as 10 μM. An in vitro scratch assay revealed that galunisertib significantly enhanced cellular migration and in vitro wound closure beginning 24 h post-injury. A gene expression analysis demonstrated a significant attenuation of fibrotic gene expression, including collagen-1a, alpha-smooth muscle actin, fibronectin, and connective tissue growth factor, with increased expression of the antifibrotic genes MMP1 and decorin. Protein synthesis assays confirmed drug activity and corroborated the transcription findings. In summary, galunisertib simultaneously exerts antifibrotic effects on dermal fibroblasts while enhancing rates of in vitro wound closure. Galunisertib has already completed phase II clinical trials for cancer therapy with minimal adverse effects and is a promising candidate for the treatment and prevention of pathological cutaneous scars.
Relative Frequencies of PAX6 Mutational Events in a Russian Cohort of Aniridia Patients in Comparison with the World’s Population and the Human Genome
Authors: Vasilyeva Tatyana A. , Marakhonov Andrey V. , Kutsev Sergey I. , Zinchenko Rena A.
Published: June 2022

Genome-wide sequencing metadata allows researchers to infer bias in the relative frequencies of mutational events and to predict putative mutagenic models. In addition, much less data could be useful in the evaluation of the mutational frequency spectrum and the prevalent local mutagenic process. Here we analyzed the PAX6 gene locus for mutational spectra obtained in our own and previous studies and compared them with data on other genes as well as the whole human genome. MLPA and Sanger sequencing were used for mutation searching in a cohort of 199 index patients from Russia with aniridia and aniridia-related phenotypes. The relative frequencies of different categories of PAX6 mutations were consistent with those previously reported by other researchers. The ratio between substitutions, small indels, and chromosome deletions in the 11p13 locus was within the interval previously published for 20 disease associated genomic loci, but corresponded to a higher end due to very high frequencies of small indels and chromosome deletions. The ratio between substitutions, small indels, and chromosome deletions for disease associated genes, including the PAX6 gene as well as the share of PAX6 missense mutations, differed considerably from those typical for the whole genome.
The Effect of Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation on Erythropoiesis and Oxidative Stress in Rats
Authors: Tsakanova Gohar , Avetisyan Aida , Karalova Elena , Abroyan Liana , Hakobyan Lina , Semerjyan Anna , Karalyan Naira , Arakelova Elina , Ayvazyan Violetta , Matevosyan Lusine , Navasardyan Arpine , Ayvazyan Anna , Davtyan Hakob , Grigoryan Bagrat , Arakelyan Arsen , Karalyan Zaven
Published: June 2022

Anemia is a commonly observed consequence of whole-body exposure to a dose of X-ray or gamma irradiation of the order of the mean lethal dose in mammals, and it is an important factor for the determination of the survival of animals. The aim of this study was to unravel the effect of laser-driven ultrashort pulsed electron beam (UPEB) irradiation on the process of erythropoiesis and the redox state in the organism. Wistar rats were exposed to laser-driven UPEB irradiation, after which the level of oxidative stress and the activities of different antioxidant enzymes, as well as blood smears, bone marrow imprints and sections, erythroblastic islets, hemoglobin and hematocrit, hepatic iron, DNA, and erythropoietin levels, were assessed on the 1st, 3rd, 7th, 14th, and 28th days after irradiation. Despite the fact that laser-driven UPEB irradiation requires quite low doses and repetition rates to achieve the LD50 in rats, our findings suggest that whole-body exposure with this new type of irradiation causes relatively mild anemia in rats, with subsequent fast recovery up to the 28th day. Moreover, this novel type of irradiation causes highly intense processes of oxidative stress, which, despite being relatively extinguished, did not reach the physiologically stable level even at the 28th day after irradiation due to the violations in the antioxidant system of the organism.
On Producing Accurate Rating Predictions in Sparse Collaborative Filtering Datasets
Authors: Margaris Dionisis , Vassilakis Costas , Spiliotopoulos Dimitris
Published: June 2022

The typical goal of a collaborative filtering algorithm is the minimisation of the deviation between rating predictions and factual user ratings so that the recommender system offers suggestions for appropriate items, achieving a higher prediction value. The datasets on which collaborative filtering algorithms are applied vary in terms of sparsity, i.e., regarding the percentage of empty cells in the user–item rating matrices. Sparsity is an important factor affecting rating prediction accuracy, since research has proven that collaborative filtering over sparse datasets exhibits a lower accuracy. The present work aims to explore, in a broader context, the factors related to rating prediction accuracy in sparse collaborative filtering datasets, indicating that recommending the items that simply achieve higher prediction values than others, without considering other factors, in some cases, can reduce recommendation accuracy and negatively affect the recommender system’s success. An extensive evaluation is conducted using sparse collaborative filtering datasets. It is found that the number of near neighbours used for the prediction formulation, the rating average of the user for whom the prediction is generated and the rating average of the item concerning the prediction can indicate, in many cases, whether the rating prediction produced is reliable or not.
Developing Wound Moisture Sensors: Opportunities and Challenges for Laser-Induced Graphene-Based Materials
Authors: Crowe Emma , Scott Cameron , Cameron Sarah , Cundell Jill H. , Davis James
Published: June 2022

Recent advances in polymer composites have led to new, multifunctional wound dressings that can greatly improve healing processes, but assessing the moisture status of the underlying wound site still requires frequent visual inspection. Moisture is a key mediator in tissue regeneration and it has long been recognised that there is an opportunity for smart systems to provide quantitative information such that dressing selection can be optimised and nursing time prioritised. Composite technologies have a rich history in the development of moisture/humidity sensors but the challenges presented within the clinical context have been considerable. This review aims to train a spotlight on existing barriers and highlight how laser-induced graphene could lead to emerging material design strategies that could allow clinically acceptable systems to emerge.
Lessons from the Conservatory Model as a Basis for Undergraduate Education and the Development of Intelligence
Authors: Sternberg Robert J. , Jarvin Linda , Desmet Ophélie Allyssa
Published: June 2022

We review the musical conservatory as a model for educators to learn how to enhance admissions, instruction, and assessment in liberal arts collegiate settings. Although conservatories serve primarily students wishing to enter musical careers of various kinds, the model on which they are based can, in many ways, serve any student and any school. We review some of the history of conservatories and describe how they work. Next, we explore how they develop a wide range of technical, cognitive, affective, and conative skills. Finally, we show how the skills they develop are important not just for music students but also for all students who will enter the world of work and face difficult and unexpected adaptive challenges.
(E)-7-(4-(Diphenylamino)styryl)benzo[c][1,2,5]thiadiazole-4-carbonitrile
Authors: Chmovzh Timofey N. , Kudryashev Timofey A. , Rakitin Oleg A.
Published: June 2022

Donor-acceptor-donor (D-A-A) structures with 2,1,3-benzothiadiazole as an internal acceptor and the 4(7)-cyanogroup as anchor acceptor have been investigated for various photovoltaic applications such as dye-sensitized solar cells (DSSCs) and organic light emitting diodes (OLEDs). They are usually obtained by cyanation of 4(7)-bromo-2,1,3-benzothiadiazoles. In this communication, the reaction of (E)-4-(2-(7-bromobenzo[c][1,2,5]thiadiazol-4-yl)vinyl)-N,N-diphenylaniline with cyanating agents was studied and it was shown that the best yield of (E)-7-(4-(diphenylamino)styryl)benzo[c][1,2,5]thiadiazole-4-carbonitrile was achieved by heating with zinc cyanide in NMP at 120 °C in the presence of tetrakis(triphenylphosphine)palladium (0). The structure of newly synthesized compound was established by means of an elemental analysis, high resolution mass-spectrometry, 1H, 13C-NMR, IR, UV spectroscopy and mass-spectrometry.
Effect of Y on Recrystallization Behavior in Non-Oriented 4.5 wt% Si Steel Sheets
Authors: Qin Jing , Zhao Haibin , Wang Dongsheng , Wang Songlin , Yang Youwen
Published: June 2022

4.5 wt% Si steel sheets with four different yttrium (Y) contents (0, 0.006, 0.012 and 0.016 wt%) were fabricated by hot rolling, normalizing, warm rolling and a final annealing process. Y addition greatly weakened the γ -fiber (⟨111⟩//ND) texture and enhanced the {001} ⟨130⟩ and {114} ⟨481⟩ texture components, and the magnetic properties were improved related to the effects of Y on the recrystallized grain nucleation. Y segregation at the grain boundaries inhibited the nucleation of {111} oriented grains at grain boundaries, which was beneficial to the nucleation and growth of other oriented grains elsewhere. At the same rolling reduction, Y2O2S inclusion caused more stress concentration than Al2O3 inclusion. Y2O2S in deformed grains with low energy storage provided more preferential nucleation sites for {001} ⟨130⟩ and {114} ⟨481⟩ grains. Strong {001} ⟨130⟩ and {114} ⟨481⟩ recrystallization textures due to the high mobility were obtained in samples containing 0.012 wt% Y.
Characteristics of Doped TiO2 Nanoparticle Photocatalysts Prepared by the Rotten Egg White
Authors: Lu Chung-Ming , Sharma Raju Kumar , Lin Pin-Yun , Huang Yi-Hsun , Chen Jung-Sheng , Lee Wen-Chien , Chen Chien-Yen
Published: June 2022

In this study, expired egg white was used as a template, and a sol–gel method was employed to prepare pure-phase TiO2 nano-powder and mixed-phase powders doped with NaF and NaI. The influences of different calcination temperatures, doping elements, and doping amounts during the preparation process on the photocatalytic performance and activity of the prepared TiO2 powders were studied. The results of the experiments showed that the F-doped TiO2 had the highest photocatalytic activity when the doping amount was 1.2%, as examined by EDS, where the sintering temperature was 500 °C. F-doped TiO2 nanoparticles were also synthesized by the sol–gel method using tetrabutyl titanate and NaF mixed with expired egg white protein as the precursor. The F-TiO2 photocatalyst was characterized using FE-SEM, HR-TEM, EDS, XPS, and UV-Vis, and the photocatalytic activity was evaluated by photodegradation of methylene blue under visible light. The results showed that doping with F reduced the energy band gap (3.04 eV) of TiO2, thereby increasing the photocatalytic activity in the visible-light region. The visible-light wavelength range and photocatalytic activity of the catalyst were also affected by the doping amount.
Experimental Study on Triaxial Compressive Mechanical Properties of Polypropylene Fiber Coral Seawater Concrete
Authors: Shi Hang , Mo Linlin , Pan Mingyan , Liu Leiguo , Chen Zongping
Published: June 2022

In order to study the mechanical properties of polypropylene fiber all-coral seawater concrete in triaxial compression, 36 specimens were developed and constructed for triaxial compression load testing employing confining pressure value (0, 6, 12, 18 MPa) and polypropylene fiber admixture (1 kg·m−3, 2 kg·m−3, 3 kg·m−3) as variation parameters. The test observed the failure mode of the specimen and obtained the stress–strain curve of the whole process of its force damage failure. An in-depth analysis of polypropylene fiber all-coral seawater concrete’s peak stress, peak strain, initial elastic modulus, axial deflection, energy dissipation, ductility, and damage evolution process was carried out based on the experimental data. The test findings indicated that the best effect on the deformation properties of polypropylene fiber all-coral seawater concrete is obtained when 3 kg·m−3 of polypropylene fiber is blended. Under triaxial compression, the correct number of polypropylene fibers may significantly enhance the peak stress, peak strain, ductility, and elastic modulus of polypropylene fiber all-coral seawater concrete, therefore enhancing the brittle characteristics of coral concrete. During the triaxial surround pressure test, the confining pressure value and polypropylene fiber coupling effect delayed the appearance of initial damage in polypropylene fiber complete coral seawater concrete specimens, slowed the development of damage, and reduced the degree of damage to the specimens.
Theoretical Study on the Structural, Elastic, Electronic and Thermodynamic Properties of Long-Period Superstructures h- and r-Al2Ti under High Pressure
Authors: Wen Yufeng , Zeng Xianshi , Ye Yuanxiu , Gou Qingdong , Liu Bo , Lai Zhangli , Jiang Daguo , Sun Xinyuan , Wu Minghui
Published: June 2022

The formations of long-period superstructures strongly influence the properties of Al-rich L10-TiAl intermetallic alloys. To soundly understand the role of the superstructures in the alloys, fundamentals about them have to be known. In the present work, the structural, elastic, electronic and thermodynamic properties of h- and r-Al2Ti long-period superstructures under pressure up to 30 GPa were systematically investigated using first-principles calculations based on density functional theory. The pressure dependence of structural parameters, single-crystal elastic constants, polycrystalline elastic modulus, Cauchy pressures and elastic anisotropy were successfully calculated and discussed. The total and partial densities of states at different pressures were also successfully calculated and discussed. Furthermore, combining with quasi-harmonic approximation, the effects of the pressure on the temperature dependent volume, isothermal bulk modulus, thermal expansion coefficient, heat capacity and Gibbs free energy difference were successfully obtained and discussed. Our results were consistent with the available experimental and theoretical values.
Al13Fe4-Al Composites with Nanocrystalline Matrix Manufactured by Hot-Pressing of Milled Powders
Authors: Krasnowski Marek , Gierlotka Stanislaw , Zasada Dariusz
Published: June 2022

The paper describes composites with the matrix containing a nanocrystalline intermetallic Al13Fe4 phase and microcrystalline aluminium. Mechanically alloyed Al80Fe20 powder, containing a metastable nanocrystalline Al5Fe2 phase, was mixed with 20, 30, and 40 vol.% of Al powder and consolidated at 750 °C under the pressure of 7.7 GPa. During the consolidation, the metastable Al5Fe2 phase transformed into a nanocrystalline Al13Fe4 phase. In the bulk samples, Al13Fe4 areas were wrapped around by networking Al regions. The hardness of the Al13Fe4-Al composites was in the range of 4.52–5.50 GPa. The compressive strength of the Al13Fe4-30%Al and Al13Fe4-40%Al composites was 805 and 812 MPa, respectively, and it was considerably higher than that of the Al13Fe4-20%Al composite (538 MPa), which failed in the elastic region. The Al13Fe4-30%Al and Al13Fe4-40%Al composites, in contrast, showed some plasticity: namely, 1.5% and 9.1%, respectively. The density of the produced composites is in the range of 3.27–3.48 g/cm3 and decreases with the increase in the Al content.
Influence of Abrasive Treatment on a Transformation of Zirconium Oxide Used in Dental Prosthetics
Authors: Regulska Kinga , Januszewicz Bartłomiej , Klimek Leszek
Published: June 2022

Zirconium oxide is a ceramic most often used in the field of dentistry for permanently cementing the substructures of prosthetic restorations in patients. The surface of zirconium oxide should be prepared properly because in the next stage it must be covered with porcelain. The success of prosthetics treatment depends on various factors, but it has been reported that the transformation of zirconium oxide plays a key role. The purpose of the research was to investigate the effect of abrasive blasting on the transformation of zirconium oxide. The research has shown that this type of surface treatment causes the transformation of the tetragonal phase into a monoclinic one. The samples were examined using X-ray diffraction (XRD). The study confirmed the assumption.
Mesitylene Tribenzoic Acid as a Linker for Novel Zn/Cd Metal-Organic Frameworks
Authors: Bejan Dana , Dascalu Ioan-Andrei , Shova Sergiu , Trandabat Alexandru F. , Bahrin Lucian G.
Published: June 2022

Three new Metal-Organic Frameworks, containing mesitylene tribenzoic acid as a linker and zinc (1) or cadmium as metals (2,3), were synthesized through solvothermal reactions, using DMF/ethanol/water as solvents, at temperatures of 80 °C (structures 1 and 3) and 120 °C (structure 2). Following single-crystal X-ray diffraction, it was found that 1 and 3 crystallize in the P21/c and C2/c space groups and form 2D networks, while 2 crystallizes in the Fdd2 space group, forming a 3D network. All three frameworks, upon heating, were found to be stable up to 350 °C. N2 sorption isotherms revealed that 1 displays a BET area of 906 m2/g. Moreover, the porosity of this framework is still present after five cycles of sorption/desorption, with a reduction of 14% of the BET area, down to 784 m2/g, after the fifth cycle. The CO2 loading capacity of 1 was found to be 2.9 mmol/g at 0 °C.
Insight into a Nitrogen-Doping Mechanism in a Hard-Carbon-Microsphere Anode Material for the Long-Term Cycling of Potassium-Ion Batteries
Authors: Chen Changdong , Zhao Kai , La Ming , Yang Chenghao
Published: June 2022

To investigate the alternatives to lithium-ion batteries, potassium-ion batteries have attracted considerable interest due to the cost-efficiency of potassium resources and the relatively lower standard redox potential of K+/K. Among various alternative anode materials, hard carbon has the advantages of extensive resources, low cost, and environmental protection. In the present study, we synthesize a nitrogen-doping hard-carbon-microsphere (N-SHC) material as an anode for potassium-ion batteries. N-SHC delivers a high reversible capacity of 248 mAh g−1 and a promoted rate performance (93 mAh g−1 at 2 A g−1). Additionally, the nitrogen-doping N-SHC material also exhibits superior cycling long-term stability, where the N-SHC electrode maintains a high reversible capacity at 200 mAh g−1 with a capacity retention of 81% after 600 cycles. DFT calculations assess the change in K ions’ absorption energy and diffusion barriers at different N-doping effects. Compared with an original hard-carbon material, pyridinic-N and pyrrolic-N defects introduced by N-doping display a positive effect on both K ions’ absorption and diffusion.
A Computer-Assisted Preoperative Path Planning Method for the Parallel Orthopedic Robot
Authors: Li Jian , Cui Rui , Su Peng , Ma Lifang , Sun Hao
Published: June 2022

Background: Trajectory planning is the premise of the control of orthopedic robots, which is directly related to the safety of the human body. However, to date, the trajectory of orthopedic robots has been restricted to lines and spline curves. This limits the flexibility of the robot and leads to unsatisfactory performance. In this paper, a trajectory planning method based on improved RRT* and B-spline curve is proposed in order to improve the control accuracy and flexibility. Method: Firstly, combined with the shortcomings of current trajectory planning methods and bone docking task analysis, the characteristics of the trajectory for orthopedic robot are illustrated, and the problem is described. Secondly, a sampling strategy and an extension strategy are proposed to solve the optimal problem of the RRT* algorithm. Meanwhile, B-spline curve is selected for path smoothing. Thirdly, based on our orthopedic robot, kinematics analysis is introduced briefly, and hypotonic polynomial is used to fit the joint variables. Finally, a comparative study of the improved RRT*, RRT*, and other algorithms are completed, and the feasibility of the robot’s trajectory is verified by algorithm simulation and platform simulation. Results: Compared with RRT*, shorter path and high node utilization are shown in the improved RRT*, which cut down about 1mm in the average path length and increased about half in the average node utilization. In the meantime, the fitting results are accepted, and the results of algorithm simulation and platform simulation showed good consistency and feasibility. Conclusions: This study revealed that the improved RRT* was superior to RRT*, and the proposed method could be used for the trajectory planning of parallel orthopedic robots, which has some significance for bone fracture and deformity correction.