bluuebunny/crossref_metadata_2025 huggingface dataset:
Migraine Generative Artificial Intelligence based on Mobile Personalized Healthcare
Authors: Yong Michelle Ting-Ting , Ho Sin-Ban , Tan Chuie-Hong
Published: February 2025

Migraine is a complicated genetic disorder characterized by episodes of moderate-to-severe headaches that are usually unilateral and are frequently accompanied by nausea and increased sensitivity to sound and light. A migraine attack induces intense pain, hindering an individual from engaging in daily activities and potentially persisting for hours or even days. By the growth of the Internet of Things, we have new opportunities to try to apply it to the medical field. To identify the origin of a migraine, specialists need access to a patient's medical history and a comprehensive understanding of migraine symptoms for effective treatment. Determining the true source of a migraine may take longer than expected. Nowadays, solving problems through the Internet has become very common in people's lives. Hence, the objective of this research is to create a mobile personalized healthcare mechanism that can assist migraine patients in promptly receiving optimal and precise treatment. Moreover, this research would establish a user-friendly interface that facilitates the presentation of compelling evidence regarding the repercussions of patient health issues. Additionally, machine learning training was designed to treat patients based on relevant demographic characteristics of the healthcare treatment, such as medical history and reports provided. Therefore, this paper can provide insights into the state of art in mobile based personalized healthcare system to recommend future paths, for integration and investigation to improve online migraine platforms for a wide range of migraine patients.
Exploration of The Impact of Cyber Situational Awareness On Small and Medium Enterprises (SMEs) in Malaysia
Authors: Tan Chee Keong , Kadar Khan Sofiah , Khattak Umar Farooq
Published: February 2025

The objective of this study is to explore the cyber situational awareness (CSA) level among the employees of small and medium-sized enterprises (SME) in Malaysia, by extending Endsley's situation awareness (SA) theory. It is crucial to understand the level of cyber situational awareness among employees as it sheds light on how well the employees understand the cyber threats and if they can handle them effectively. Literature has reviewed that SMEs are subject to a greater danger of cyber-attacks. Therefore, employees' awareness of cyber situations is of the utmost significance in studying cyber security. A convenient non-probability sampling method was chosen due to less expensive to deploy and increase the efficiency of data collection processes. IBM SPSS was used to conduct descriptive exploration data analysis that provides insight into the employee's current CSA by categorizing the employees into good, average, and poor understanding of the CSA. A total of 443 surveys were collected in the study, the findings reveal that most employees are not adequately aware of cyber situations, and employees understand the need to adhere to cyber security policy within the organization but fail to comply. The study contributes to practical domain by identifying the current level of CSA, SMEs should be set forth to create a strong culture of cyber security awareness and compliance and prioritize cyber security as part of the organization's culture to improve overall employee engagement and motivation in dealing with cyber threats.
Personalized Drug Recommendation System Using Wasserstein Auto-encoders and Adverse Drug Reaction Detection with Weighted Feed Forward Neural Network (WAES-ADR) in Healthcare
Authors: J Omana , P. N Jeipratha , K Devi , S Benila , K Revathi
Published: February 2025

In recent years, the use of deep learning approaches in healthcare has yielded promising results in a variety of fields, most notably in the detection of adverse drug reactions (ADRs) and drug recommendations. This paper promises a breakthrough in this field by using Wasserstein autoencoders (WAEs) for personalized medicine recommendation and ADR detection. WAEs' capacity to manage complex data distributions and develop meaningful latent representations makes them ideal for modeling heterogeneous healthcare data. This study intends to improvise the precision and efficiency of drug recommendation systems while also improving patient safety by combining WAEs and early ADR detection strategies. Previous research has used social media data for pharmacovigilance, drug repositioning, and other machine learning algorithms to detect ADRs. However, our proposed methodology offers a novel perspective by combining Wasserstein autoencoders with ADR detection methods, outperforming existing approaches. Preliminary results show that the proposed methodology surpasses current methodologies, with much greater accuracy in ADR identification and medicine recommendation. In particular, the proposed model achieves an ADR detection accuracy of 96.04%, which is 15% higher than the most sophisticated techniques, with considerable improvements in precision, recall, and accuracy metrics. In conclusion, our study seeks to develop customized medicine in healthcare, perhaps leading to dramatically improved patient outcomes and safety.
Consumption of Two New Complementary Feeds (RENAL+MP) in Cats with Chronic Kidney Disease, a Single-Blinded Pet-Owner Evaluation
Authors:   MP Labo, Marketing & Communication, Grasse, France, Navarro Christelle , Baise Carole ,   MP Labo, Pharmaceutical Affairs, Grasse, France, Boudjedir-Rouffy Clemence ,   Technisens, Consumer Research Department, La Rochelle, France, Jahier Bruno ,   MP Labo, Scientific Affairs, Grasse, France
Published: February 2025

Chronic kidney disease (CKD) is a common condition in elderly cats. Its management requires notably the use of a therapeutic
diet and phosphate binders. As CKD is frequently associated with poor appetite, it may impair the intake of complementary
feeds in sick cats versus healthy cats.
Objectives: This study evaluated the rate of consumption of 2 new complementary feeds in cats with CKD.
Methods: 41 owners of cats with CKD were randomly assigned to Group 1 (G1 = Renal+MP Early, MP Labo, France, n=21)
or Group 2 (G2 = Renal+MP Advanced, MP Labo, France, n=20). Products were masked. Cats received 1 measuring spoon of
powder for 5 kg twice a day for 5 days with a meal. On D1 and D5, owners rated the meal consumption: 100%, 90 to 100%, 50
to 90%, 5 to 50%, less than 5%, or nothing. Total and partial consumption were respectively defined as 100% and more than
50% of intake. Khi2 test was used to compare proportions of cats between days in each group.
Results: At the end of the study, total consumption was reported for 43% and 30% of cats and partial consumption for 72% and
75% of cats in G1 and G2, respectively. No statistical differences were found on D5 vs D1, except in G2 for ’90 to 100%’ and
‘50 to 90%’. 86% and 90% of owners found products easy to give in G1 and G2, respectively.
Conclusions: The two new feed supplements (Renal+MP) showed an acceptable level of intake in cats with CKD over a 5-day
period.
Tinea Capitis: Evolution of the Epidemiological Profile at IBN ROCHD University Hospital of Casablanca (Morocco)
Authors:   Parasitology and mycology department, IBN ROCHD University Hospital of Casablanca, Morocco, Soussi-Abdallaoui M , Marhraoui L E , Hali F , Chiheb S , Elfatoiki F ,   Dermatology and venereology Department, IBN ROCHD University Hospital of Casablanca, Morocco
Published: February 2025

Tinea capitis is a fungal infection affecting school-age children in Morocco. A study at Ibn Rochd University Hospital
in Casablanca found 267 patients, mostly males (69.6%), with an average age of 7.24 years. Microsporum. canis
was the most prevalent pathogen (56.5%), followed by Trichophyton. violaceum (18.3%). The study indicates that
Microsporum canis is emerging as the leading cause, linked to changes in animal populations and pet ownership.
Systematic mycological exams before treatment are crucial.
Kajian Sosio Semiotika Megalitikum Pada Sistus Tantaduo Taman Nasional Lore Lindu
Authors: Nidyah Widyamurti  , Jauhari Jauhari , Yudhanto Sigied Himawan
Published: February 2025

Situs Tantaduo merupakan situs megalitikum yang berada di Lembah Bada taman nasional lore lindu, pada situs tantaduo terdapat sebuah arca yang dikenal dengan nama Watu Baula, arca Watu Baula sebagai objek megalitikum di analisis dengan pendekatan sosio semiotika eco yang terdiri dari signifikansi, kode, dan konteks untuk kemudian di interpretasikan dengan metode hubungan diadik dan triadik antara denotasi, konotasi, dan dan objek dapat diwakili oleh skema segitiga yang terkenal. Hasil penelitian secara analisis deskriptif menunjukan bahwa secara sosio semiotika bentuk arca terdapat berbagai objek penanda yang ditemukan pada badan artefak megalitikum di arca Watu Baula situs Tantaduo, seperti lingkaran garis-garis, corak, guratan dan bolongan -bolongan pada badan arca, memiliki tanda simbolik sebagai reperesentasi masyarakat yang sudah melakukan kegiatan bercocok tanam dalam kehidupan sosial masyarakat megalitikum. Bentuk lingkaran dan bolongan melambangkan symbol siklus hidup dan keberlanjutan, sedangkan ukiran manusia mencerminkan penghormatan terhadap leluhur. di lembah Bada selalu menunjukkan adanya hubungan budaya atau 'bahasa' komunikasi antara kelompok-kelompok masyarakat di wilayah tersebut. Hal tersebut mengindikasikan bahwa kondisi masyarakat lokal di sekitar situs-situs megalitikum tersebut memiliki kesamaan dalam sistem simbolik sebagai 'bahasa' dan kepercayaan mereka.
Jana Kertih: Kemuliaan Manusia dalam Penciptaan Seni Lukis
Authors: Setem Wayan
Published: February 2025

Tujuan dari penelitian dan penciptaan seni ini adalah mencipta dan menyajikan karya “Jana Kertih: Kemuliaan Manusia dalam Penciptaan Seni Lukis” sebagai representasi upaya membangun kualitas sumber daya manusia menuju manusia berkualitas suputra sadhu gunawan. Model penciptaan seni lukis menjadi ekspresi budaya yang mampu memainkan peran sebagai media peningkatan apresiasi masyarakat untuk membangkitkan Jana Kertih menuju Jana Hita membangun manusia berkualitas secara individu agar menjadi SDM yang sehat secara jasmani, dan rohani. SDM yang demikian itulah yang dapat berperan membangun kehidupan bersama untuk menciptakan rasa aman, damai, dan sejahtera. Penciptaan ini berbasis riset dengan demikian metodenya terdiri dari  dua bagian yang tidak terpisah yakni metode penelitian dan metode penciptaan. Sedangkan metode penciptaan melewati tiga tahap yakni: eksplorasi, improvisasi, dan perwujudan karya yang didahului dengan telaah karya seni sejenis  dan kajian literatur. Tahapan eksprimen/percobaan alat dan bahan untuk menemukan desain penyajian karya yang memiliki kebaruan yang kemudian diseminasikan untuk menyampaikan konsep Jana Kertih memuliakan manusia yang mengetahui hakikat dan tujuan hidup sebagai manusia sesuai ajaran agama dan memahami nilai-nilai etis, estetis dan religius.
The Eksistensi Karya Seni Rupa Islam dalam Medan Seni Rupa Indonesia: Studi Kasus Pameran Fragments of Modern Indonesian Art History di OHD Museum Magelang
Authors: Khairi Miftahul
Published: February 2025

This research explains the development of Islamic art in the modern and contemporary Indonesian art scene through Rispul and Tita Rubi's works collected by OHD Museum. The fundamental question is how OHD's taste in choosing its collection? How is the curation process in the exhibition Fragment of Modern Indonesian Art History? And why Rispul and Titarubi's works were chosen for the exhibition? This question is explained through the sociology of art theory from Becker and Bourdieu and uses a qualitative method with a case study approach. The results of the study show that OHD as a pure collector by providing distinction to the works he will collect, thereby gaining legitimacy in the Indonesian and Asian art scene. His legitimacy is able to influence the world of art collecting in Indonesia and Asia. The works of Tita Rubi and Rispul were collected and selected for the exhibition because they fit the criteria of being part of the development of contemporary art and continuing the Islamic art series.
صعوبات تدريس مهارات التحدث باللغة العربية الفُصحى في المرحلة الثانوية من وجهة نظر معلمات اللغة العربية والحلول المقترحة لها
Authors: د.نجلاء بنت خالد بن عبدالله العتيبي
Published: February 2025

هدفت الدّراسة إلى التعرف على صعوبات تدريس مهارات التحدث باللغة العربية الفُصحى لدى طالبات المرحلة الثانوية، وتحديد الحلول المقترحة لمعالجة تلك الصعوبات من وجهة نظر معلمات اللغة العربية؛ ولتحقيق أهداف الدراسة؛ اتبعت الباحثة المنهج الوصفي المسحي، والاستبانة كأداة لجمع البيانات وبعد التحقق من صدقها وثباتها وزعت على عينة الدراسة والمكونة من معلمات اللغة العربية في المرحلة الثانوية والبالغ عددهن(160)معلمةً، وبعد إجراء التحليلات اللازمة، توصلت الدراسة إلى النتائج الآتية: وجود صعوبات في تدريس مهارات التحدث باللغة العربية الفُصحى في المرحلة الثانوية من وجهة نظر معلمات اللغة العربية بدرجة مرتفعة، الأمر الذي يستدعي معالجتها، وأخذها بعين الاعتبار، وكانت أبرز تلك الصعوبات افتقار الطالبات إلى الثقة بالنفس عند التحدث باللغة العربية الفُصحى، وندرة المواد التعليمية الجذابة التي تحفّز الطالبات على التحدث باللغة العربية الفُصحى، غياب المواقف الحقيقية التي تدفع الطالبات إلى التحدث باللغة العربية الفُصحى بطريقة تفاعلية وتواصلية، كما كشفت النتائج عن اتفاق معلمات اللغة العربية للمرحلة الثانوية بدرجة مرتفعة على سبل التغلب على صعوبات تدريس مهارات التحدث باللغة العربية الفُصحى، وأوصت الدراسة بضرورة غرس الثقة بالنفس لدى الطالبات من خلال تفعيل الأنشطة الصفية والمتمثلة في الحوارات القصيرة أو تمثيل مشاهد درامية، أو إلقاء الخطابات والنقاشات المفتوحة.
دور المرشد الطلابي في الحد من الايذاء البدني لطلاب المرحلة الابتدائية شرق الرياض بمكتب التربية والتعليم بقرطبة
Authors: فرحان زميلان العنزي
Published: February 2025

تعد ظاهرة الإيذاء من الظواهر العالمية التي لا يخلو منها مجتمع، ويكمن الاختلاف بين المجتمعات في حجم الظاهرة وحدتها وأسبابها وأساليب التعامل معاها. كما تعد المدرسة ثاني مؤسسات التنشئة الاجتماعية بعد الأسرة، فهي أحد المؤسسات التي تربي قبل أن تعلم الطفل، بل وتهذب سلوكه وتعالجه، ولكن المدرسة تواجه العديد من التحديات والمتغيرات متعددة في مواجهة العنف تجاه الطلاب وسلوكهم وهي تعمل جنبا إلى جنب مع الأسرة لإكساب الفرد قيما دينية وتربوية وأخلاقية، لكي يصبح مواطنا صالحا في المجتمع.
بداية لابد من الإشارة أن ظاهرة إيذاء الطلاب من الظواهر المستترة بصفة عامة إي أن ما يظهر منها لا يمثل حجمها الحقيقي. وفي المجتمعات المحافظة- مثل المجتمع السعودي يأخذ الأمر بعدا أهم من نواحي عديدة. فلقد لزم المجتمع السعودي الصمت لفترة طويلة، تجاه ظاهرة إيذاء الطلاب في البداية بسبب عدم تعريفها والتعرف عليها، وفي مرحلة لاحقة إنكار الظاهرة وعدم الاعتراف بها، واللجوء إلى التقليل من أهمية الحالات التي ظهرت في أوقات متفرقة لقلة عددها ولعدم كون الأمر يستحق الاهتمام.
وأشارت الدراسات أن هناك رغبة للمرشد في القضاء على إنحراف السلوك لدى طلابهم، وعدم وضوح الرؤية لدى البعض في الإجراءات التي يتخذونها تجاه السلوك المنحرف لدى طلابهم.
ويعرف المرشد الطلابي ودوره هو مجموعة الأساليب والوسائل التي يتبعها المرشد الطلابي لتعريف الطلاب والهيئة الادارية والتعليمية بالمدرسة بدوره في المدرسة والخدمات التي يقدمها لهم.
Effect of gamma irradiation and modified atmosphere packaging on postharvest behavior of dragon fruit
Authors: Saran F Y , Hassan M K , Akhther N
Published: February 2025

The experiment was conducted at the Postharvest Laboratory of the Department of Horticulture, Bangladesh Agricultural University, Mymensingh during the period of September to October, 2022 to find the effects of gamma irradiation and modified atmosphere packaging on postharvest behavior of dragon fruit. The experiment was laid out in completely randomized design with three replications. There were four treatments, viz. T0: Control, T1: gamma irradiation at 1000 Gy, T2: 1000 Gy irradiated fruits wrapped in non-perforated PP bag (25μ) containing KMnO4, T3: 1000 Gy gamma irradiated fruits wrapped in 25μ perforated PP bag containing KMnO4. Data were recorded on weight loss, firmness, color, flavor, shrinkage, freshness, appearance, total doluble sugar (TSS), diseases severity and shelf life at different days after storage. The longest shelf life (7.7 days) was recorded in 1000 Gy irradiated fruits and the shortest shelf life (5.3 days) was found in untreated control. .The minimum weight loss (0.01%) was found in 1000 Gy gamma irradiated fruits wrapped in non-perforated PP bag containing KMnO4 and maximum weight loss (3.44%) in untreated control at 7th day after storage. The findings would greatly contribute in reducing postharvest loss of dragon fruit and maintain their quality during storage and marketing at ambient condition.
Bangladesh J. Nuclear Agric, 38(2): 1-13, 2024
Binalebu-3: A high yielding, year-round, scented and seedless variety of lemon
Authors: Alam M S , Islam M R
Published: February 2025

An investigation was carried out in three consecutive years at the Horticulture Division, Bangladesh Institute of Nuclear Agriculture (BINA), Mymensingh to characterize lemon germplasm for varietal development. Thirty-one local and exotic lemon germplasm were collected from home and abroad. The germplasm CL-0021 and CL-0027 were collected from Darziling, India. These two germplasm alone with check variety were evaluated during 2017-18, 2018-19 and 2019-20 at two location viz.Kashiar char, Mymensingh and Garobazar, Madhupur, Tangail. The experiments were carried out following randomized complete block design with three replications. BAUlebu-4 was used as a check variety in the experiments. From the results it was observed that CL-0021 was found to be superior to other exotic genotype and check variety BAUlebu-4 in case of fruit setting, disease and disease resistant. During 2017-18, 2018-19 & 2019-20 at Mymensingh, the highest fruit yield plant-1(55.50, 42.23 kg and 33.01 kg respectively), vitamin C (88.15, 88.21and 88.14 mg 100 g-1), plant height (225.55 cm, 189.11 cm and 165.01 cm), fruit length (7.92, 7.71  cm and 7.69 cm), number of fruits plant-1 (250.00, 2014.24 and 150.00), juice content fruit-1 (48.00%, 46.22% and 44.74%) and the lowest number of seeds fruit-1 (4.2,4.1, and 4) was recorded from CL-0021 in all the three consecutive year trials. Similar results were also observed at another location, Garobazar, Madhupur, which was higher compared to CL-0027 and BAUlebu-4 at both locations. The lowest fruit yield plant-1, vitamin C, the highest number of seeds fruit-1 observed at CL-0027 at both of Mymensingh and Tangail. Considering the better performance of fruit yield, vitamin C content, juice content and less number of seeds compare to CL-0021, CL-0027 and BAUlebu-4; CL-0021 genotype was selected as a new variety naming Binalebu-3 to grow commercially all over Bangladesh.
Bangladesh J. Nuclear Agric, 38(2): 27-34, 2024
Effect of different beneficial insects as pollinator on fruit setting of litchi inflorescence Bangladesh
Authors: Hossen M A , Haque M E , Ahmed M T , Hasan S A M G
Published: February 2025

An experiment was carried out at the BAU Germplasm Centre (GPC), Bangladesh Agricultural University, Mymensingh during February to May, 2021 to study the effect of beneficial insects on litchi flower pollination and fruit setting. The experiment was laid out in a Randomized Complete Block Design with three replications of four litchi varieties viz. Mongolbari, China-3, Bombai, Mozzafforpuri. In each replication same number of blooming flower was considered for the study. The data were recorded on the number of flower per inflorescence, beneficial insects per inflorescence, fruit set per inflorescence and fruit dropping record. It was found that most of the beneficial insects were hymenopteran and dipteran insects which covered 89 percent of total beneficial insects. Honey bee and syrphid fly were found as better pollinator. In this experiment maximum number of fruit set per inflorescence was found in the Bombai variety, where the highest number of beneficial insects (2.49) per variety was found. On the other hand, lowest number of beneficial insects (1.37) and lowest fruit set was found in China-3 variety (6.33) where harmful insects were higher (1.72). After pollination when fruit set was at marble stage, number of fruit set and fruit dropping per inflorescence was recorded. So, it can be concluded that beneficial insects as pollinators play a direct role in litchi flower pollination and fruit set. It could be concluded that timely establishment of colonies in sufficient number and conservation of the pollinators in litchi orchard is essential to ensure better pollination and fruit set of litchi.
Bangladesh J. Nuclear Agric, 38(2): 89-96, 2024
Adoption and profitability of Binadhan-16 in some selected areas of Bangladesh
Authors: Sultana R , Rahman R H , Sarkar M M A , Haque M R , Islam S
Published: February 2025

The study was conducted in three Binadhan-16 growing areas of Bangladesh, namely Mymensingh, Netrokona and Rangpur districts. The objectives of the study were to find out the determinants of adoption of Binadhan-16 rice variety at the farm level and to estimate the costs and return of Binadhan-16 cultivation in the study areas. Moreover, some problems of the Binadhan-16 cultivation were also investigated in this study. This study was based on primary data which were collected from 180 farmers, 60 from each district where 30 was adopter and 30 was non-adopter of Binadhan-16 growers. Data were collected through face to face interview with the help of a pre-designed interview schedule from three upazillas i e. Valuka (Mymensingh), Purbadhala (Netrokona) and Sadar (Rangpur). Descriptive statistics and logit regression model were used to fulfill the objectives. The result of logit regression model shows that farm size, yield, seed, training and extension contact have positive and significant effect on Binadhan-16 adoption. Education and cultivation duration were found as negatively significant variables in explaining the variation in Binadhan-16 adoption. The study also found that total variable cost of Binadhan-16 cultivation was Tk. 44346 per hectare which was 66.78% of total cost of production. The highest cost item was human labour which accounted for 46.44 % of the total cost. Cost of land preparation was 17.84% and land use cost accounted for 14.63% of total cost and ranked as second and third cost items, respectively. On an average, the total cost of production was Tk. 66404 per hectare where 33.22% was fixed costs and 66.78% was variable cost. It was found that Binadhan-16 production is profitable. The highest yield was found at Rangpur (5546 kg ha-1) followed by Mymensingh (5379 kg ha-1) and Netrokona (5297 kg ha-1). The average selling price of Binadhan-16 was Tk. 24.88 kg-1 where cost of production was Tk. 12.28 kg-1. The average gross margin was found Tk. 98756 on variable cost basis. The average net return per hectare was Tk. 76698. The average Benefit Cost Ratio (BCR) was 2.16. Regarding major problems of the variety cultivation, 15% mentioned about high labour cost which  ranked top followed by quality seed in timely manner (14%), infestation of disease (11%), scarcity of labour (9%), low price of paddy and high transportation cost (8%). As the variety yield higher profit more emphasis should be given on farm size, seed, yield, and training programme for the expansion of the variety.
Bangladesh J. Nuclear Agric, 38(2): 125-135, 2024
Texting While Driving: Computerized Eye Tracking as a Method to Assess Visual Distraction During Driving Simulations
Authors: Litwiler Scott , Hasley Joseph P. , Maldonado Edgar , Segall Mark , Garman George
Published: February 2025

According to the National Traffic Highway Traffic Safety Administration, distracted driving claimed 3,308 lives in 2022. Few studies have used simulated driving experiences to directly assess the impact on gaze while driving with a cell phone distraction present. In this research, gaze was monitored using a commercial eye tracker mounted to a laptop computer while subjects watched a 10-minute video of normal daytime driving. There was a consistent decrease in objects of interest being observed while text messages appeared. A negative but not statistically significant relationship between the amount of media use (based on responses from the questionnaire) and the amount of time that subjects viewed each text was found (p = 0.072). However, as overall risk for poor driving increased, gaze related to other vehicles decreased (p = 0.014). These results reveal that having a cellphone while driving likely impairs one's ability to notice potentially hazardous conditions on the road that could lead to the harm of the driver or others.
Cultural Barriers of Poverty Alleviation in the Microfinancing of Market Women in the Effutu Municipality of Ghana
Authors: Shirley Dankwa  , Kwakye Bio , Quartey Robert , Eshun Isaac
Published: February 2025

This study explored three main aspects: the awareness of microfinance’s role, the barriers to accessing microfinance services, and the effects of microfinance on poverty alleviation among market women in the Effutu Municipality in the Central Region of Ghana. A qualitative approach and case study design were employed in this study. The population of the study was women traders in Effutu Municipality. Purposive and convenient sampling techniques were employed to select 15 participants. A semi-structured interview guide was the instrument used for data collection. Thematic analysis was used to analyze the data. The findings of this study were that while microfinance has the potential to enhance economic stability and improve the quality of life of market women, significant barriers such as difficulties in securing guarantors, delays in loan disbursements, and cumbersome repayment processes limit its effectiveness. It is recommended that microfinance institutions strengthen their outreach programs through partnerships with local radio stations, community leaders, and existing beneficiaries to spread awareness about the availability of their services and benefits.
Assessing mutation accumulation in DNA repair-deficient Listeria monocytogenes: implications for cgMLST cluster thresholds in outbreak analysis
Authors: Füszl Astrid , Pietzka Ariane , Hyden Patrick , Mösenbacher Tobias , Stöger Anna , Blaschitz Marion , Stadlbauer Silke , Hasenberger Petra , Schindler Stefanie , Heger Florian , Pleininger Sonja , Indra Alexander
Published: February 2025

Background

Listeria (L.) monocytogenes is primarily transmitted via contaminated food and can cause listeriosis, an infection often associated with sepsis and meningitis in at-risk individuals. Accurate outbreak detection relies on whole genome sequencing (WGS) and core genome multilocus sequence typing (cgMLST), which use allele thresholds to identify related strains.

Methods

This study investigated mutation rates in L. monocytogenes, focusing on isolates with DNA repair deficiencies. Serial subcultivations were performed, comparing a repair-deficient isolate with a wild-type control. Genetic variability was assessed using WGS and cgMLST.

Results

Mutation rates were significantly higher in repair-deficient isolates, exceeding typical cgMLST thresholds currently used in Listeria outbreak investigations, leading to a misclassification of related isolates as unrelated. An additional analysis of the Austrian Listeria database revealed that such deficiencies are rare among isolates.

Conclusions

The standard 7-allele cgMLST threshold effectively identifies related strains in most cases, but may require adjustments for hypermutator strains. Incorporating DNA repair data could improve the accuracy of outbreak investigations, ensuring reliable public health responses.
A systematic review on evaluating school safety signs and ways to improve its effectiveness
Authors: Wang Tongxu , Abdul Shukor Shureen Faris , Kozlowski Marek , Wan Mohamed Wan Srihani , Zhang Ting
Published: February 2025

Introduction

Safety signs are essential visual communication tools that convey critical information regarding hazards, regulations, and emergency procedures across various environments. Their significance has garnered considerable attention due to their role in enhancing public safety. However, existing studies have predominantly focused on design factors, with limited research addressing the interaction of non-design factors among specific age groups and safety communication in public spaces, particularly concerning young children’s cognitive abilities and perceptions.

Methods

This systematic review aims to comprehensively analyze the characteristics and effectiveness of safety signs within the school environment. A systematic review of the literature on safety signs—specifically their design within school premises—was conducted using the Systematic Review and Meta-Analyses (PRISMA) approach to identify research gaps. Query strings were utilized to extract papers, identifying 48 peer-reviewed articles from 2000 to 2024 for review.

Results

The review found that visual elements, such as dynamic safety signs and the use of highly saturated colors, significantly enhance the effectiveness of warnings. Several factors were identified that influence the efficacy of safety signs, including age-related cognitive abilities and the contextual understanding of young children. Additionally, the study highlights the effectiveness of technological tools, such as eye tracking and virtual reality (VR), for assessing human perception and improving testing methodologies. The role of enjoyment and experiential learning in enhancing safety communication are beneficial.

Discussion

This systematic review underscores the importance of considering both design and non-design factors in safety sign development, particularly in school environments. The findings suggest that dynamic, visually appealing signs, along with the use of advanced technological tools, can improve the effectiveness of safety messages. The integration of experiential learning also contributes to a better understanding of safety information. This review is a valuable resource for safety science researchers, visual designers, and policymakers by providing insights into the current state of research, identifying research gaps, and offering perspectives on the future of school safety signage pertinent to school-age children.
The thixotropic mechanical properties and microscopic mechanism of lime-modified loess
Authors: Zhang Shaowei , Dang Faning , Guan Hao
Published: February 2025

The thixotropy of lime-modified loess is a key engineering problem in large-scale mountain levelling and urban construction on the Loess Plateau in China. We analyse the thixotropic factors and establish thixotropic models of modified loess at macroscales and microscales to interpret the evolution of the thixotropic mechanism of lime-modified loess. A custom-made volume-preserving thixotropic instrument is used to eliminate the influence of consolidation deformation on thixotropy and simulate soil consolidation in the field. Consolidated undrained triaxial tests, nuclear magnetic resonance analysis, and electron microscopy are used to investigate the thixotropy of soils with different thixotropic periods (0 days, 7 days, 14 days, 21 days, 42 days, 84 days, 126 days, and 168 days). The results show that the failure strength increases and the growth rate decreases with the thixotropic period length. The failure strength increases rapidly in the early thixotropic stage; the inflexion point occurs at 21 days, and stabilisation is observed at about 42 days. The internal friction angle and cohesive force increase over time, the cohesive force increased more obviously, which was 2.94 times of the initial thixotropic period, the increase in internal friction angle is within 4°. The pore distribution is more uniform at the microscopic level, and large and small pores are transformed into medium pores over time. As the thixotropic period increases, the amount of cementitious material generated in the modified loess and the cementation degree increase, and the number of surface pits and large pores on the particles substantially decreases, resulting in numerous flower-shaped and grid structures. The thixotropic mechanism of modified loess consists of pore homogenisation, gravitational repulsion between particles, and cementation caused by the lime reaction.
Flexible-resource coordination supply recovery of active distribution network considering multiple demand responses
Authors: Bingbing Chen , Jiateng Liu , Haotian Wu , Haiwei Wang , Yunfan Chen
Published: February 2025

As the risk of extreme fault conditions to power supply reliability escalates, the importance of supply recovery within active distribution networks (ADNs) is exponentially increasing. However, the utilization of a single resource strategy is insufficient to fully exploit the supply recovery potential of the ADN’s diverse and flexible resources. Therefore, a flexible resource coordination supply recovery for ADN considering multiple demand responses is proposed. This strategy utilizes distributed generation (DG) and energy storage system (ESS) as distributed power supply units, and involves the operational flexibility of soft open points (SOPs) to couple DGs with ESSs. Meanwhile, the demand response consisting of transferable and interruptible loads is taken into account, with its load regulation capability harnessed to supply recovery. A supply recovery model is established to coordinate the flexibility of source, network, and demand sides, which is further transformed into a second-order cone programming (SOCP) model to enhance solution efficiency with accuracy preservation. Simulations conducted on a modified IEEE 33-node system validate the effectiveness of the proposed strategy in maximizing supply recovery.
Case report: A novel intronic JMJD6 likely pathogenic variant (c.941+75G > T) associated with congenital eyelid coloboma in one of the identical twin sisters
Authors: Li Xin , Zhang Yuqi , Chai Gang , Su Weijie , Zhang Yan
Published: February 2025

Background

Congenital eyelid coloboma (CEC) is a rare genetic disease, manifesting as a congenital partial or total defect of the eyelid. In this study, we report a pedigree with CEC caused by a novel pathogenic variant in JMJD6.

Case report

The proband was a 3-year-old girl who presented with a congenital coloboma of the left upper eyelid, accompanied by hypoplasia of the ipsilateral eyebrow. Karyotype analysis was normal. Whole-exome sequencing (WES) identified a novel pathogenic variant in JMJD6 (c.941+75G > T), which was classified as a likely pathogenic (LP) and de novo variant. To date, this variant has not been reported.

Conclusion

Our study found a novel pathogenic variant in JMJD6 (c.941+75G > T), which broadens the CEC phenotype spectrum and JMJD6 gene variant spectrum, providing a basis for clinical diagnosis, genetic counseling, and treatment.
Women with premenstrual syndrome exhibit high interoceptive accuracy, but low awareness, with parasympathetic rebound responses from stress
Authors: Suzuki Yumiko Crysia , Ohira Hideki
Published: February 2025

Premenstrual syndrome (PMS) is characterized by emotional or physical discomfort that occurs specifically during the luteal phase. However, women with PMS typically do not exhibit abnormalities in serum sex hormone levels or structural anomalies, making it challenging to identify distinct pathological findings unique to PMS. Instead, they may exhibit hypersensitivity to fluctuations in sex hormone levels within the normal range. This study involved experiments conducted in the late luteal phase. The pre-stress baseline state evaluated the effects of PMS on interoception using the Heartbeat Counting Task (HCT) and the Multidimensional Assessment of Interoceptive Awareness (MAIA), and the effects on emotional states using a questionnaire assessing subjective emotions in the late luteal phase. The results indicated that the “PMS group” scored higher on the HCT compared to the “without PMS group,” while their MAIA scores were lower. Additionally, the PMS group reported experiencing more negative and stressful states. The findings suggest that women with PMS demonstrate high accuracy in but lower awareness of interoception. This mismatch between “accuracy” and “awareness” may indicate a maladaptive state regarding mental health. The stress-related analysis examined whether the effects of stress on exacerbating PMS include impacts on interoception and the autonomic nervous system (ANS). States before baseline, immediately after, and during stress recovery were evaluated. The results revealed that women in the PMS group exhibited more pronounced negative and stressful states; they showed higher scores on the HCT, with scores progressively increasing as the task was repeated. Regarding ANS indices, no main effect of group was observed, but parasympathetic activity increased during the recovery period compared to the pre-stress baseline. In the degree of changes in parasympathetic activity from the baseline to post-stress and recovery periods, a group-by-time interaction effect was observed. These findings suggest that the PMS group may experience a prolonged rebound effect during the recovery phase following induced stress. In conclusion, women with PMS exhibit a discrepancy between high interoceptive accuracy and low awareness of their sensations. This may contribute to heightened discomfort and suggest that vulnerability to stress, mediated by the parasympathetic nervous system, exacerbates factor for PMS symptoms.
Neurotoxicity mechanisms and clinical implications of six common recreational drugs
Authors: Wang Jing , Hao Yulei , Ma Di , Feng Liangshu , Yang Feng , An Pingxu , Su Xingqi , Feng Jiachun
Published: February 2025

The recreational abuse of addictive drugs poses considerable challenges to public health, leading to widespread neurotoxicity and neurological dysfunction. This review comprehensively examines the neurotoxic mechanisms, clinical manifestations, and treatment strategies associated with six commonly abused substances: methamphetamine, cocaine, synthetic cathinones, ketamine, nitrous oxide and heroin. Despite their diverse pharmacological properties, these drugs converge on shared neurotoxic pathways, including oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation. Psychostimulants, such as methamphetamine, cocaine and synthetic cathinones, disrupt monoaminergic neurotransmission, causing cognitive impairment, psychiatric disturbances, and neurovascular damage. Dissociative anesthetics, including ketamine and nitrous oxide, impair glutamatergic transmission and mitochondrial function, thereby exacerbating excitotoxicity and neuronal apoptosis. Opioids, such as heroin, primarily target the brain’s reward system and induce oxidative stress, neuroinflammation, and cerebrovascular complications. Treatment strategies remain limited, focusing on symptomatic management, neuroprotective interventions, and behavioral therapies. Emerging approaches, such as antioxidants, NMDA receptor modulators, and cognitive rehabilitation, show promise but require further validation. By highlighting the underlying mechanisms and therapeutic challenges, this review provides a foundation for developing targeted interventions and advancing research on drug-induced neurotoxicity.
Exploring how sensory dominance modulated by modality-specific expectation: an event-related potential study
Authors: Tang Xiaoyu , Fan Dandan , Wang Xueli , Xing Zepeng , Yu Shilong , Wang Aijun , Yu Hongtao
Published: February 2025

The Colavita visual dominance effect refers to the phenomenon in which tend to respond only or preferentially to visual stimuli of bimodal audiovisual stimulus. Previous evidence has indicated that sensory dominance can be modulated by top-down expectation. However, it remains unclear how expectations directed toward a single sensory modality influence Colavita visual dominance at the electrophysiology level. Using event-related potential (ERP) measurements, we investigated how modality expectation modulates sensory dominance by manipulating the different unimodal target probabilities used in previous related Colavita studies. For the behavioral results, a significantly larger visual dominance effect was found when the modality expectation was directed to the visual sensory condition (40% V:10% A). Further ERPs results revealed that the mean amplitude of P2 (200–250 ms) in the central-parietal region was larger in the visual precedence auditory response (V_A) type than in the auditory precedence visual response (A_V) type when modality expectation was directed to visual sensory stimuli (40% V:10% A). In contrast, the mean amplitude of N2 (290–330 ms) in the frontal region was larger for the V_A type than in the A_V type when modality expectation was directed to the auditory sensory stimuli (10% V:40% A). Additionally, for the A_V type N1 (150–170 ms) in the frontal region was larger in visual versus auditory expectation condition. Overall, the study tentatively suggested that increasing unimodal target probability may lead to greater top-down expectation direct to target modality stimulus, and then sensory dominance emerges in the late phase when participant response to visual stimuli of bimodal audiovisual stimulus.
Prevalence of stress and associated factors among students in Ethiopia: a systematic review and meta-analysis
Authors: Bezie Anmut Endalkachew , Abere Giziew , Zewude Girum Tareke , Desye Belay , Daba Chala , Abeje Eyob Tilahun , Keleb Awoke
Published: February 2025

Introduction

Stress is an increasing public health issue among the student population. This stress affects their academic performance, mental health, and overall well-being. As a result, we conducted a systematic review and meta-analysis to determine the pooled prevalence and associated factors of stress among students in Ethiopia.

Methods

An extensive search of electronic databases such as PubMed, Google Scholar, Semantic Scholar, HINARI, and Science Direct, cross-referencing, and Google manual search was conducted to identify cross-sectional studies published from 1998 to 2024. The preferred PRISMA guideline was used to report items for this systematic review and meta-analysis. To extract data, Microsoft Excel 16 and to analyze STATA 17 software were used. The JBI quality assessment tool was used for the included studies with medium to high-quality scores. To estimate the pooled prevalence of stress and its associated factors, a random effects model was used. The funnel plot and Egger’s regression test were used to assess publication bias, and I2 test statistics were used to determine heterogeneity of the included studies. The protocol for this review has been registered with PROSPERO (ID: CRD42024578490).

Results

A total of 23 studies with 8,946 study participants met the inclusion criteria. The pooled prevalence of stress among students in Ethiopia was 37.64% (95% CI: 29.61–45.66; I2 = 98.8%). Female gender (OR = 1.82, 95% CI: 1.57–2.12), rural resident (OR = 1.51, 95% CI: 1.22–1.87), living outside university dormitory (OR = 2.02, 95% CI: 1.34–3.05), the habit of alcohol consumption (OR = 1.46, 95% CI: 1.12–1.91), being a cigarette smoker (OR = 2.36, 95% CI: 1.49–3.74), being a khat chewer (OR = 1.35, 95% CI: 1.02–1.80), working in an unfavorable environment (OR = 1.80, 95% CI: 1.20–2.71), and having poor social support (OR = 1.93, 95% CI: 1.39–2.68), were significantly associated with an increased risk of stress.

Conclusion

The findings of this systematic review and meta-analysis indicated a high prevalence of stress among students. The study identified female gender, being a rural residence, living outside a university dormitory, khat chewing, having the habit of alcohol consumption, working in an unfavorable environment, poor social support, and cigarette smoking as significant risk factors for stress. To develop coping skills and resilience, integrating mental health education into the curriculum could help students to prevent stress. Furthermore, strategies such as academic support programs, substance use reduction programs, counseling services, and stress management workshops could be beneficial.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024578490, CRD42024578490.
Hybrid Feel-Own-Move®: protocol for an effectiveness-implementation study of a psychomotor intervention for survivors of domestic violence
Authors: Machorrinho Joana , Veiga Guida , Marmeleira José , Scheffers Mia , Santos Graça Duarte
Published: February 2025

Background

Domestic violence is a public health concern, impacting the health and well-being of women and children globally. Shelter homes are one of the support services for victims’ recovery, although providing holistic healthcare in this setting remains a struggle. Feel-Own-Move® (FOM) is an evidence-based psychomotor intervention designed to help women who have experienced domestic violence reconnect with their bodies. Hybrid FOM (H-FOM) is a version of FOM that combines in-person with online sessions for both women and children living in shelter homes. To examine the effectiveness and implementation success of H-FOM are the aims of this study.

Methods

This protocol details an effectiveness-implementation type I hybrid study, to be carried out in shelter homes across three European countries. Health outcomes of the participants, and the implementation success within professionals from the shelter homes and the psychomotor therapists responsible for implementing H-FOM will be assessed. Results will be analyzed through a mixed methods approach, following the conceptual model of implementation science and the RE-AIM framework.

Discussion

This effectiveness-implementation study is expected to contribute to understanding H-FOM health-related effects on women and children survivors of violence, as well as to its sustainable implementation, up-scaling and integration into trauma support services and associated healthcare policy. H-FOM is expected to (i) improve the known effects of FOM on women survivors of DV, while ensuring continuity of the therapeutic process following relocation, and promoting the health and well-being of children living in the shelter homes.
Threats to masculinity evoke status-quo-reinforcing racism, xenophobia, and Islamophobia
Authors: Vescio Theresa K. , Yamaguchi-Pedroza Katsumi , Schermerhorn Nathaniel E. C. , Loviscky Abigail J.
Published: February 2025

Culturally idealized forms of masculinity have been suggested to be endorsed and internalized by men, resulting masculine identities that are easily threatened and inspire status-quo-reinforcing outcomes. The present examined whether receiving gender-incongruent feedback, which was predicted to threaten masculinity in men (but not femininity in women), serially led to public discomfort, anger, and status-quo-reinforcing prejudice toward members of marginalized groups. To test predictions, men and women in two studies (N = 606) took an apparent gender knowledge test and received feedback indicating that their scores were more similar to the average score of women or men. Consistent with predictions, when men received gender-incongruent information they felt more public discomfort and subsequent anger that, in turn, predicted anti-Black attitudes (Study 1), anti-immigrant attitudes (Study 2), and Islamophobia (Study 2); these effects were not significant among women. The present findings replicate prior research showing that, when receiving gender-incongruent information, men experience threats to masculinity that lead to acts of dominance and aggression, which reinforce men-s dominance over women. The present findings also provide novel evidence that threats to men's masculinity—via public discomfort and anger—arouse White men's dominance over marginalized masculinities.