bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Fragment-to-lead Approaches Starting from the 7-azaindole: The
Pharmacological Versatility of a Privileged Molecular Fragment
Authors: Marcos Santos Leandro , da Silveira Nelson José Freitas
Published: July 2023

Fragment-based drug discovery is one of the most powerful paradigms in the recent context
of medicinal chemistry and is being widely practiced by academic and industrial researchers.
Currently, azaindoles are among the most exploited molecular fragments in pharmaceutical innovation
projects inspired by fragment-to-lead strategies. The 7-azaindole is the most prominent representative
within this remarkable family of pyrrolopyridine fragments, as it is present in the chemical
structure of several approved antitumor drugs and also of numerous therapeutic candidates. In
this paper, a brief overview on existing proofs of concept in the literature will be presented, as well
as some recent works that corroborate 7-azaindole as a privileged and pharmacologically versatile
molecular fragment.
Novel and Predictive QSAR Model and Molecular Docking: New Natural
Sulfonamides of Potential Concern against SARS-Cov-2
Authors: Moussa Nathalie , Mando Huda
Published: July 2023

Background:

Since the outbreak of the COVID-19 pandemic in 2019, the world has been racing to develop effective drugs for treating this deadly disease. Although there are now some vac-cines that have somewhat alleviated global panic, the lack of approved drugs remains a persistent challenge. Consequently, there is a pressing need to discover new therapeutic molecules.

Methods:

In this study, we explore the application of a quantitative structure−activity relationship (QSAR) model to predict the efficacy of 28 cyclic sulfonamide derivatives against SARS-CoV-2. The model was developed using multiple linear regression, and six molecular descriptors were identified as the most significant factors in determining the inhibitory activity. This proposed QSAR model holds the potential for aiding the virtual screening and drug design process in the development of new and more effective SARS-CoV-2 inhibitors. The model was also applied to seven natural products primary sulfonamides and sulfamates, demonstrating promising activity

Results:

The study results indicated that the atom count, as represented by the descriptor nCl, had the most significant impact on the inhibitory activity against SARS-CoV-2. The proposed model was val-idated using various statistical parameters, confirming its validity, robustness, and predictiveness, with a high correlation coefficient (R2) of 0.77 for the training group and 0.95 for the test group. Further-more, we predicted the activity of seven natural compounds, and among them, Dealanylascamycin exhibited the highest predicted activity. Subsequently, Dealanylascamycin was docked to SARS-CoV-2 and the results of the docking study further strengthened its potential as a promising candidate against COVID-19, suggesting that it should be considered for further optimization and validation.

Conclusion:

Our findings demonstrate promising predicted inhibitory activity against SARS-CoV-2 for seven natural products, primary sulfonamides, and primary sulfamates.
Progress on Polyolefin/Graphene Nanocomposites with High Dielectric
Constant and Low Dielectric Loss for Electrical Applications
Authors: Aldosari Haia , Madkhali Nawal , Algasser Saja , Khairy M.
Published: July 2023

Introduction:

The attached oxygen functional group in graphene oxide (GO) with layers
that are about 1.1 ± 0.2 nm thick, has hindered the performance of electrical characteristics. Diminution
of the oxygen functional group, and increasing the carbon/oxygen (C/O) ratio can enhance electrical
conductivity.

Method:

This study investigated the effect of graphene derivatives (C/O) ratios on the dielectric properties
of low-density polyethylene (PE) made of metallocene, as well as polypropylene (PP)
and mixtures of them. The oxygen functional groups were reduced by utilizing graphene oxide (GO)
and reduced graphene oxide (rGO). The effect of GO and rGO-based polyolefin produced by solution
blending while lowering the oxygen functional group is explored.

Result:

The surface morphology and chemical structure were examined by using a scanning electron
microscope (SEM) and Fourier Transformed Infrared Spectroscopy (FTIR). The electrical characteristics
of the composite films, such as their loss factor (tan δ) and dielectric constant, permittivity and
conductivity, and imaginary permittivity were examined. At room temperature, measurements were
performed at frequencies ranging from 300 Hz to 8 MHz. ε'; the dielectric permittivity and imaginary
permittivity (ε") of polymer/ reduced graphene oxidehowever, these values rapidly decreased with increasing

Conclusion:

The alternating current conductivity of the composites was likewise shown to increase
with increasing frequency.
Improving the Performance of Solar Thermal Energy Storage Systems
Authors: NKELE AGNES , Ikhioya Imosobomeh , Chime Chinedu , EZEMA FABIAN
Published: July 2023

In recent times, renewable energy resources have been greatly researched because of the increasing concern to minimize global warming and meet energy demands. Energy storage systems have become useful tools for sustainability and meeting energy needs. Solar energy has proven in recent times to be the primary and most prevalent option due to its environmental friendliness, availability, and minimal pollution. Effective utilization of available energy resources has led to developing new alternative energy devices like the solar thermal energy storage system (STESS) with a solar energy source. Solar thermal energy systems are efficient systems that utilize solar energy to produce thermal and electrical energy. This review aims to give a detailed overview of solar TESS, different TES application systems, and effective methods of increasing the system performance to provide energy during deficient times. The various classifications, basic components, the principle of operation, application areas of STESSs, prospects, and extensive reviews on these aspects have also been discussed in this review. The different factors to be considered geared towards meeting energy demands and increasing the efficiency of solar TES systems have been duly detailed. This review is a single manuscript with a detailed overview of STESS, the principle of operation and components of STESS, thermal energy storage materials, a description of different application systems, and a discussion of factors responsible for improving the system efficiency.
Dimensions of Interactive Pervasive Game Design: Systematic Review
Authors: Kai Liu , Tan Wee Hoe , Saari Erni Marlina
Published: July 2023

Background

As the gaming industry grows around the world, playing pervasive games is becoming an important mode of entertainment. A pervasive game is one in which the game experience extends into the actual world or where the fictive world of the game merges with the physical world. How pervasive games can adapt to the ever-changing nature of technology and design in current society requires a comprehensive review.

Objective

In this systematic review, we aimed to measure and analyze 4 dimensions of pervasive games through development, technology, experience, and evaluation. Moreover, we also aimed to discover and interpret their relationship with game, interaction, experience, and service design.

Methods

We first chose 3 well-known databases, Web of Science, Scopus, and EBSCO, and searched from 2013 to April 2022. A strictly thorough Boolean search for research keywords such as “pervasive game,” “design,” and “interactive” resulted in 394 relevant articles. These articles were identified, screened, and checked for eligibility to find valid and useful articles, which were then categorized and analyzed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method.

Results

The systematic selection was finally left with 40 valid and valuable articles. After categorization and analysis, all articles were classified according to 4 main themes, which were design and development (11/40, 28%), interaction and technology (15/40, 38%), users and experience (9/40, 23%), and evaluation and service (5/40, 13%). These 4 main areas can be subdivided into several smaller areas.

Conclusions

In the 4 areas of game design, interaction design, experience design, and service design, many scholars have studied pervasive games and made contributions. Although the development and technology of pervasive games have evolved with the times, there is still a need to strengthen emerging design concepts within pervasive games.
Experiences and Perceptions of Telehealth Visits in Diabetes Care During and After the COVID-19 Pandemic Among Adults With Type 2 Diabetes and Their Providers: Qualitative Study (Preprint)
Authors: Sun Chun-An , Shenk Zachary , Renda Susan , Maruthur Nisa , Zheng Stanley , Perrin Nancy , Levin Scott , Han Hae-Ra
Published: July 2023

BACKGROUND

Since the COVID-19 pandemic, telehealth has been widely adopted in outpatient settings in the United States. Although telehealth visits are publicly accepted in different settings, little is known about the situation after the wide adoption of telehealth from the perspectives of adults with type 2 diabetes mellitus (T2D) and their providers.

OBJECTIVE

This study aims to identify barriers and facilitators of maintaining continuity of care using telehealth for patients with T2D in a diabetes specialty clinic.

METHODS

As the second phase of a multimethod study to understand missed appointments among adults with T2D, we conducted semistructured, individual, in-depth phone or Zoom interviews with 23 adults with T2D (14/23, 61% women; mean age 55.1, SD 14.4, range 35-77 years) and 10 providers from diabetes clinics in a tertiary academic medical center in Maryland. Interviews were audio-recorded, transcribed, and analyzed using thematic content analysis by the research team.

RESULTS

Adults with T2D and their providers generally reported positive experiences with telehealth visits for diabetes care with some technical challenges resulting in the need for in-person visits. We identified the following 3 themes: (1) “perceived benefits of telehealth visits,” such as convenience, time and financial efficiencies, and independence from caregivers, benefits shared by both patients and providers; (2) “perceived technological challenges of telehealth visits,” such as disparities in digital health literacy, frustration caused by unstable internet connection, and difficulty sharing glucose data, challenges shared by both patients and providers; and (3) “impact of telehealth visits on the quality of diabetes care,” including lack of diabetes quality measures and needs and preferences for in-person visits, shared mainly from providers’ perspectives with some patient input.

CONCLUSIONS

Telehealth is generally received positively in diabetes care with some persistent challenges that might compromise the quality of diabetes care. Telehealth technology and glucose data platforms must incorporate user experience and user-centered design to optimize telehealth use in diabetes care. Clinical practices need to consider new workflows for telehealth visits to facilitate easier follow-up scheduling and lab completion. Future research to investigate the ideal balance between in-person and telehealth visits in diabetes care is warranted to enhance the quality of diabetes care and to optimize diabetes outcomes. Policy flexibilities should also be considered to broaden access to diabetes care for all patients with T2D.
Web-Based Survey Piloting Process as a Model for Developing and Testing Past Contraceptive Use and Pregnancy History: Cystic Fibrosis Case Study (Preprint)
Authors: Godfrey Emily M , Schwartz Malaika  R , Stukovsky Karen D Hinckley , Woodward Danielle , Magaret Amalia S , Aitken Moira L
Published: July 2023

BACKGROUND

Individuals with complex, chronic diseases are now living longer, making reproductive health an important topic to address in the health care setting. Self-respondent surveys are a feasible way to collect past contraceptive use and pregnancy history to assess contraceptive safety and effectiveness. Because sensitive topics, such as contraception and pregnancy outcomes, can vary across social groups or cultures, piloting questions and evaluating survey administration procedures in the target population are necessary for precise and reliable responses before wide distribution.

OBJECTIVE

This study aimed to develop a precise and reliable survey instrument and related procedures among individuals with cystic fibrosis regarding contraceptive use and obstetrical history.

METHODS

We piloted and tested web-based questions related to contraceptive use and pregnancy history among 50 participants with and those without cystic fibrosis aged 18 to 45 years using a 3-tier process. Findings from each tier informed changes to the questionnaire before testing in the subsequent tier. Tier 1 used cognitive pretesting to assess question understanding and the need for memory prompts. In tier 2, we used test-retest self- and interviewer-administered approaches to assess question reliability, evaluate response missingness, and determine confidence between 2 types of survey administration approaches. In tier 3, we tested the questionnaire for clarity, time to complete, and whether additional prompts were necessary.

RESULTS

In tier 1, respondents suggested improvements to the web-based survey questions and to the written and visual prompts for better recall regarding past contraceptive use. In tier 2, the test-retest reliability between self- and interviewer-administrative procedures of “ever use” contraceptive method questions was similar, with percent absolute agreement ranging between 84% and 100%. When the survey was self-administered, the percentage of missing responses was higher and respondent confidence about month and year when contraceptive methods were used was lower. Most respondents reported that they preferred the self-administered survey because it was more convenient and faster to complete.

CONCLUSIONS

Our 3-tier process to pilot web-based survey questions related to contraceptive and obstetrical history in our complex disease population helped us tailor content and format questions before wide dissemination to our target population. Results from this pilot study informed the subsequent larger study design to include a 10% respondent test-retest self- and interviewer-administered quality control component to better inform imputation procedures of missing data.

CLINICALTRIAL
The Effects of Reinforcement Techniques in Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: Protocol for a Web-Based Survey, Systematic Review, and Meta-Analysis (Preprint)
Authors: Xie Yunhui , Wen Jun , Zhu Hongmei , Liu Yanjun
Published: July 2023

BACKGROUND

The effects of reinforcement are still controversial in bariatric surgery, and variations may exist in using this technique.

OBJECTIVE

This protocol describes a study that aims to survey the views of bariatric surgeons on reinforcement techniques and evaluate the effects of applying reinforcement techniques in sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB).

METHODS

This study is composed of 2 parts. Part 1 will investigate the differences of using reinforcement techniques among surgeons worldwide who perform SG or RYGB through a survey. The survey will be conducted by email and social media. Part 2 will evaluate the safety and effectiveness of using omentopexy or staple line reinforcement in SG and RYGB by systematic review and meta-analysis. In this part, literature searches will be performed in English databases, including CENTRAL, EMBASE CINAHL, Web of Science, and PubMed, and Chinese databases, including Wanfang, China National Knowledge Infrastructure, Database of Chinese Technical Periodicals, and Chinese Biological Medicine, from their establishment to November 2023. Randomized controlled trials and case-control studies will be included. The primary outcomes are rates of postoperative bleeding and gastric leakage. The secondary outcomes include anastomotic stenosis, surgical site infection, reoperation, estimated intraoperative blood loss, operative time (minutes), length of hospital stay (days), overall complications, and 30-day mortality. The meta-analysis will be conducted using RevMan 5.4 under the random-effects model, as well as through extensive subgroup and sensitivity analyses. P values <0.05 will be considered statistically significant. This study was registered with PROSPERO (Prospective Register of Systematic Reviews) in accordance with the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols).

RESULTS

The results of this study will be published in a peer-reviewed journal. The web-based survey and initial title or abstract review of papers identified by the search strategy will be completed in November 2023. The second round of title or abstract review and downloading of the papers for full-text inclusion will be completed in January 2024. We aim to complete data extraction and meta-analysis by February 2024 and expect to publish the findings by the end of March 2024.

CONCLUSIONS

This study aims to investigate the impact of reinforcement techniques on reducing the incidence of postoperative complications in SG and RYGB procedures and provide assistance for standardizing the procedures of SG and RYGB operations for bariatric surgeons.

CLINICALTRIAL

PROSPERO CRD42022376438; https://tinyurl.com/2d53uf8n

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/50677
Increasing Realism and Variety of Virtual Patient Dialogues for Prenatal Counseling Education Through a Novel Application of ChatGPT: Exploratory Observational Study (Preprint)
Authors: Gray Megan , Baird Austin , Sawyer Taylor , James Jasmine , DeBroux Thea , Bartlett Michelle , Krick Jeanne , Umoren Rachel
Published: July 2023

BACKGROUND

Using virtual patients, facilitated by natural language processing, provides a valuable educational experience for learners. Generating a large, varied sample of realistic and appropriate responses for virtual patients is challenging. Artificial intelligence (AI) programs can be a viable source for these responses, but their utility for this purpose has not been explored.

OBJECTIVE

In this study, we explored the effectiveness of generative AI (ChatGPT) in developing realistic virtual standardized patient dialogues to teach prenatal counseling skills.

METHODS

ChatGPT was prompted to generate a list of common areas of concern and questions that families expecting preterm delivery at 24 weeks gestation might ask during prenatal counseling. ChatGPT was then prompted to generate 2 role-plays with dialogues between a parent expecting a potential preterm delivery at 24 weeks and their counseling physician using each of the example questions. The prompt was repeated for 2 unique role-plays: one parent was characterized as anxious and the other as having low trust in the medical system. Role-play scripts were exported verbatim and independently reviewed by 2 neonatologists with experience in prenatal counseling, using a scale of 1-5 on realism, appropriateness, and utility for virtual standardized patient responses.

RESULTS

ChatGPT generated 7 areas of concern, with 35 example questions used to generate role-plays. The 35 role-play transcripts generated 176 unique parent responses (median 5, IQR 4-6, per role-play) with 268 unique sentences. Expert review identified 117 (65%) of the 176 responses as indicating an emotion, either directly or indirectly. Approximately half (98/176, 56%) of the responses had 2 or more sentences, and half (88/176, 50%) included at least 1 question. More than half (104/176, 58%) of the responses from role-played parent characters described a feeling, such as being scared, worried, or concerned. The role-plays of parents with low trust in the medical system generated many unique sentences (n=50). Most of the sentences in the responses were found to be reasonably realistic (214/268, 80%), appropriate for variable prenatal counseling conversation paths (233/268, 87%), and usable without more than a minimal modification in a virtual patient program (169/268, 63%).

CONCLUSIONS

Generative AI programs, such as ChatGPT, may provide a viable source of training materials to expand virtual patient programs, with careful attention to the concerns and questions of patients and families. Given the potential for unrealistic or inappropriate statements and questions, an expert should review AI chat outputs before deploying them in an educational program.
Technology-Based Interventions in Tobacco Use Treatment Among People Who Identify as African American/Black, Hispanic/Latina/o, and American Indian/Alaska Native: Scoping Review (Preprint)
Authors: Hichborn Emily , Turner Avery , Moore Sarah , Gauthier Phoebe , Bell Kathleen , Montgomery LaTrice , Boggis Jesse , Lambert-Harris Chantal , Saunders Elizabeth , Dallery Jesse , McLeman Bethany , Marsch Lisa
Published: July 2023

BACKGROUND

Although tobacco use has significantly declined in the general population, traditional tobacco use treatment uptake and success rates remain disproportionately low among people who identify as African American/Black, Hispanic/Latina/o, and American Indian/Alaska Native. Technology-based interventions (TBIs) for tobacco use are promising alternatives to traditional tobacco use treatments.

OBJECTIVE

This scoping review aims to investigate the extent to which the use of digital TBIs in tobacco use treatment research promotes health equity among people who identify as African American/Black, Hispanic/Latina/o, and American Indian/Alaska Native.

METHODS

This scoping review identifies US-based studies (between January 2000 and March 2021) that enlist TBIs for tobacco use treatment and include people who identify as African American/Black, Hispanic/Latina/o, and American Indian/Alaska Native at ≥50% of the sample when combined; features studies that are also race and ethnicity conscious; and highlights health equity–promoting insights from included studies.

RESULTS

In 85% (22/26) of the studies, the largest proportion of the sample was African American/Black, most participants had low socioeconomic status, and recruitment was most commonly from medical settings. In total, 58% (15/26) of the studies were race and ethnicity conscious, and 67% (10/15) of these studies sought to partner with potential end users. An array of TBIs were represented; however, SMS text messaging was most prevalent. Most TBIs were combined with other evidence-based intervention components (eg, nicotine replacement therapy). Approximately one-third of the studies (8/26, 31%) required participants to have their own device or internet access. The majority were underpowered to detect substantial differences.

CONCLUSIONS

The modest number of studies, particularly for persons who identify as Hispanic/Latina/o and American Indian/Alaska Native, demonstrates the limited application of TBIs for tobacco use and that additional research is needed to determine the extent to which TBIs for tobacco use promote health equity among these populations.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/34508
Evaluation of GPT-4’s Chest X-Ray Impression Generation: A Reader Study on Performance and Perception (Preprint)
Authors: Ziegelmayer Sebastian , Marka Alexander W , Lenhart Nicolas , Nehls Nadja , Reischl Stefan , Harder Felix , Sauter Andreas , Makowski Marcus , Graf Markus , Gawlitza Joshua
Published: July 2023

UNSTRUCTURED

Exploring the generative capabilities of the multimodal GPT-4, our study uncovered significant differences between radiological assessments and automatic evaluation metrics for chest x-ray impression generation and revealed radiological bias.
Machine Learning and Health Science Research: Tutorial (Preprint)
Authors: Cho Hunyong , She Jane , De Marchi Daniel , El-Zaatari Helal , Barnes Edward L , Kahkoska Anna R , Kosorok Michael R , Virkud Arti V
Published: July 2023

UNSTRUCTURED

Machine learning (ML) has seen impressive growth in health science research due to its capacity for handling complex data to perform a range of tasks, including unsupervised learning, supervised learning, and reinforcement learning. To aid health science researchers in understanding the strengths and limitations of ML and to facilitate its integration into their studies, we present here a guideline for integrating ML into an analysis through a structured framework, covering steps from framing a research question to study design and analysis techniques for specialized data types.
Pretreatment HIV Drug Resistance and the Molecular Transmission Network Among HIV-Positive Individuals in China in 2022: Multicenter Observational Study (Preprint)
Authors: Chen Hongli , Hao Jingjing , Hu Jing , Song Chang , Zhou Yesheng , Li Miaomiao , Chen Jin , Liu Xiu , Wang Dong , Xu Xiaoshan , Xin Peixian , Zhang Jiaxin , Liao Lingjie , Feng Yi , Li Dan , Pan Stephen W , Shao Yiming , Ruan Yuhua , Xing Hui
Published: July 2023

BACKGROUND

Emerging HIV drug resistance caused by increased usage of antiretroviral drugs (ARV) could jeopardize the success of standardized HIV management protocols in resource-limited settings.

OBJECTIVE

We aimed to characterize pretreatment HIV drug resistance (PDR) among HIV-positive individuals and risk factors in China in 2022.

METHODS

This cross-sectional study was conducted using 2-stage systematic sampling according to the World Health Organization’s surveillance guidelines in 8 provincial-level administrative divisions in 2022. Demographic information and plasma samples were obtained from study participants. PDR was analyzed using the Stanford HIV drug resistance database, and the Tamura-Nei 93 model in HIV-TRACE was used to calculate pairwise matches with a genetic distance of 0.01 substitutions per site. Logistic regression was used to identify and estimate factors associated with PDR.

RESULTS

PDR testing was conducted on 2568 participants in 2022. Of the participants, 34.8% (n=893) were aged 30-49 years, 81.4% (n=2091) were male, and 3.2% (n=81) had prior ARV exposure. The prevalence of PDR to protease and reverse transcriptase regions, nonnucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, and protease inhibitors were 7.4% (n=190), 6.3% (n=163), 1.2% (n=32), and 0.2% (n=5), respectively. Yunnan, Jilin, and Zhejiang had much higher PDR incidence than did Sichuan. The prevalence of nonnucleoside reverse transcriptase inhibitor–related drug resistance was 6.1% (n=157) for efavirenz and 6.3% (n=163) for nevirapine. Multivariable logistic regression models indicated that participants who had prior ARV exposure (odds ratio [OR] 7.45, 95% CI 4.50-12.34) and the CRF55_01B HIV subtype (OR 2.61, 95% CI 1.41-4.83) were significantly associated with PDR. Among 618 (24.2%) sequences (nodes) associated with 253 molecular transmission clusters (size range 2-13), drug resistance mutation sites included K103, E138, V179, P225, V106, V108, L210, T215, P225, K238, and A98.

CONCLUSIONS

The overall prevalence of PDR in China in 2022 was modest. Targeted genotypic PDR testing and medication compliance interventions must be urgently expanded to address PDR among newly diagnosed people living with HIV in China.
Dampak Environmental, Social, Dan Governance (ESG) Terhadap Kinerja Keuangan
Authors: Wahdan Arum Inawati  , Rahmawati Rahmawati
Published: July 2023

Purpose: The objective of this study is to assess how social, environmental, and governance factors impact the financial performance of companies in non-financial sectors. These three factors are assessed based on the Global Reporting Initiative (GRI) standard indicators. In addition, financial performance as a dependent variable is proxied through the Return on Assets (ROA) ratio.
Methodology/Approach: This study used quantitative data with a purposive sampling approach and selected 32 non-financial sector companies with a research period from 2019 – 2021, so that the number of research observation data used was 96 samples. Regression analysis of panel data is used for testing research hypotheses. Data analysis techniques start from descriptive statistical analysis, classical assumption tests, panel data regression model selection tests, determination coefficient tests (R2), simultaneous tests (f), and partial tests (t). The fixed effect model was selected for this study after the chow test and hausman test.
Findings: The findings of this study show that social factors, environmental factors, and governance factors have a positive influence on the financial performance of non-financial sector companies. This research provides an understanding of the application of ESG and its impact on the financial performance of non-financial sector companies in 2019-2021.
Practical and Theoretical Contribution/Originality: The implication is that increasing awareness and compliance with corporate social responsibility on the environment, social and governance on the impact of the company's operational activities is a way for corporate sustainability.
Digitalization of the construction sector of the Primorsk region
Authors:   The Russian Presidential Academy of National Economy  and  Public  Administration,  the  Far-Eastern  institute of management – branch  of  RANEPA, Agafonova G. V.
Published: July 2023

The purpose of this scientific article is to determine the level, problems, directions of digitalization of the construction industry of the Primorsk region in the modern economic conditions. Within the framework of writing this research article, such scientific methods as analysis, synthesis, comparison, methods of statistical analysis, monographic method were used. The main results and indicators of development of the construction sector of the Primorsk region are analyzed, development trends are highlighted. The assessment of the level of use of digital technologies in the construction sector of the Primorsk region is given. The problems, risks and challenges in the field of digital transformation of the construction industry of the Primorsk region are summarized and systematized. The tasks, projects and expected results in the field of digitalization of the construction industry in the Primorsk region are shown. The obtained research results can be used by the regional authorities in the field of planning and forecasting of socio-economic policy of the region; construction companies of the region, in the field of planning operational activities in the medium term; potential investors and homeowners who plan to purchase real estate.
Subjective ideas about the prestige of profession among schoolchildren of the Khabarovsk territory: sociological analysis
Authors:   The Russian Presidential Academy of National Economy  and  Public  Administration,  the  Far-Eastern  institute of management – branch  of  RANEPA, Perepechay P. E.
Published: July 2023

This scientific article studies professional stratification as a social phenomenon in the regional labor market of the Khabarovsk Territory. The author analyzes social stratification, determines its main characteristics and influence on the professional opportunities and prospects of workers in the region. The study is based on a comprehensive data analysis that includes surveys, statistics and economic indicators.The author analyzes various aspects of professional stratification such as the level of education, work experience, professional skills and qualifications, as well as social status and income. He explores the differences in access to high-paying and prestigious jobs, as well as the factors that influence the vertical and horizontal mobility of workers. The author identifies the main trends and patterns of professional stratification in the regional labor market of the Khabarovsk Territory as the result of the study. Recommendations to reduce inequality in access to professional opportunities and improvement in the situation on the labor market in the region are also offered. This article provides valuable information for researchers, practitioners and decision makers in the field of labor relations and social policy.
Law and Cinema: An Introduction
Authors:   National Research University Higher School of Economics, Erokhina Yulia V. , Galkina Nataliia ,   National Research University Higher School of Economics, Tokhtueva Elizaveta A. ,   National Research University “Higher School of Economics”
Published: July 2023

The article reveals the main trends of the “Law and Cinema” scholarly movement, which has been actively explored in the foreign legal literature in recent decades. An attempt is made to review open academic and empirical sources to identify the relationship between law and cinema, key works and contemporary publications on this topic, as well as the available criticism of research in the ﬁeld of law and cinema justiﬁcation. A deﬁnition of the scope of the “Law and Cinema” research ﬁeld in the context of the Russian research ﬁeld, the subject matter and research methodology are suggested.
Sudahkan Asas Pengelolaan Keuangan Desa Terimplementasi?
Authors: Alinsari Natasia , Nugrahesthy Aprina , Prasetya Alfiananda
Published: July 2023

Penelitian ini bertujuan untuk menganalisis kesesuaian praktik pengelolaan Dana Desa dan memberikan gambaran yang jelas tentang penerapan prinsip-prinsip pengelolaan Dana Desa dalam praktik pengelolaan Dana Desa di Desa Lerep. Penelitian ini merupakan penelitian deskriptif kualitatif dengan menggunakan fenomenologi. Objek penelitian ini adalah Desa Lerep, Ungaran Barat, Kabupaten Semarang. Sumber data dalam penelitian ini menggunakan data primer yang dikumpulkan dengan teknik wawancara mendalam dengan narasumber yang berkompeten dalam pengelolaan Dana Desa di Desa Lerep yang terdiri dari pemerintah desa dan masyarakat desa. Teknik analisis data yang digunakan adalah reduksi data, triangulasi, penyajian data, dan penarikan kesimpulan. Hasil dan pembahasan penelitian ini menunjukkan bahwa pengelolaan Dana Desa yang dilakukan oleh Pemerintah Desa Lerep mulai dari tahap perencanaan, pelaksanaan, penatausahaan, pelaporan dan pertanggungjawaban secara umum sudah sesuai dengan pedoman yang ditetapkan pemerintah dalam Permendagri 20 Tahun 2018, yaitu transparan, akuntabel, partisipatif dan dilaksanakan dengan tertib dan disiplin anggaran. Masih terdapat beberapa kendala diantaranya kurangnya pemahaman masyarakat tentang pengelolaan Dana Desa dan bencana alam, namun hal tersebut belum menjadi kendala yang berarti.
Pengaruh Latar Belakang Pendidikan, Pemanfaatan Teknologi Informasi dan Pemahaman Akuntansi Terhadap Kualitas Laporan Keuangan Pemerintah Daerah (Studi Pada OPD di Pemerintah Kabupaten Muara Bungo)
Authors: Wulan D Anissa , Yudi Yudi , Friyani Rita
Published: July 2023

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh latar belakang pendidikan, pemanfaatan teknologi informasi dan pemahaman akuntansi terhadap kualitas laporan keuangan pemerintah daerah di Kabupaten Muara Bungo, mengingat Pemerintah Kabupaten Muara Bungo mendapat opini wajar tanpa pengecualian dari Badan Pemeriksaan Keuangan Republik Indonesia (BPK-RI) untuk Laporan Keuangan Pemerintah Daerah (LKPD) tahun 2018.

Populasi dalam penelitian ini adalah seluruh OPD yang ada di Kabupaten Muara Bungo. Data yang digunakan adalah data primer yang diperoleh dari responden melalui penyebaran kuesioner. Responden dalam penelitian ini adalah kepala subbagian keuangan dan staff subbagian keuangan. data diperoleh kemudian dilakukan analisis regresi linier berganda antara variabel independen dengan variabel dependen baik secara parsial maupun secara simultan.

Hasil penelitian menunjukkan bahwa : (1) latar belakang pendidikan tidak berpengaruh terhadap kualitas laporan keuangan pemerintah daerah, (2) pemanfaatan teknologi informasi berpengaruh terhadap kualitas laporan keuangan pemerintah daerah, (3) pemahaman akuntansi berpengaruh terhadap kualitas laporan keuangan pemerintah daerah, (4) latar belakang pendidikan, pemanfaatan teknologi informasi, dan pemahaman akauntansi secara simultan berpengaruh terhadap kualitas laporan keuangan pemerintah daerah.
Pengaruh Penerapan Standar Akuntansi Pemerintahan, Kompetensi Sumber Daya Manusia dan Pemanfaatan Teknologi Informasi Terhadap Kualitas Laporan Keuangan Pemerintahan Daerah Kabupaten Bungo
Authors: Aprsiansyah Harry , Rahayu Sri , Erwati Misni
Published: July 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Penerapan Standar Akuntansi Pemerintahan, Kompetensi Sumber Daya Manusia dan Pemanfaatan Teknologi Informasi terhadap Kualitas Laporan Keuangan Pemerintah Kabupaten Bungo. Data yang digunakan dalam penelitian ini adalah data primer, dengan metode pengumpulan data dilakukan dengan menyebarkan kuesioner. Penelitian ini menggunakan sampel jenuh. Sampel yang digunakan sebanyak 36 responden. Pengolahan data menggunakan software SPSS 22. Sebelum dilakukan pengujian hipotesis dilakukan uji kualitas instrumen dan uji asumsi klasik. Hasil pengujian kualitas instrumen yang terdiri dari uji validitas dan reliabilitas menunjukkan bahwa semua item pertanyaan valid dan reliabel. Hasil uji asumsi klasik yang terdiri dari uji normalitas, uji multikolinearitas, dan uji heteroskedastisitas menunjukkan bahwa semua data memenuhi persyaratan. Hasil pengujian hipotesis menunjukkan bahwa secara simultan Penerapan Standar Akuntansi Pemerintahan, Kompetensi Sumber Daya Manusia dan Pemanfaatan Teknologi Informasi Mempengaruhi Kualitas Laporan Keuangan Pemerintah Kabupaten Bungo. Secara parsial variabel Penerapan Standar Akuntansi Pemerintahan dan Penggunaan Teknologi Informasi tidak berpengaruh terhadap Kualitas Laporan Keuangan Pemerintah Kabupaten Bungo dan variabel Kompetensi Sumber Daya Manusia berpengaruh terhadap Kualitas Laporan Keuangan Pemerintah Kabupaten Bungo.
PENGARUH UKURAN KOMITE AUDIT, FREKUENSI RAPAT KOMITE AUDIT DAN CHIEF EXECUTIVE OFFICER (CEO) GENDER TERHADAP KETEPATAN WAKTU PELAPORAN KEUANGAN
Authors: Farhan Muhammad , Mansur Fitrini , Erwati Misni
Published: July 2023

Penelitian ini bertujuan untuk memberikan bukti secara empiris pengaruh ukuran komite audit, frekuensi rapat komite audit, dan Chief Executive Officer (CEO) Gender terhadap ketepatan waktu pelaporan keuangan secara parsial dan simultan. Penelitian ini merupakan penelitian kuantitatif. Populasi dalam penelitian ini adalah perusahaan sektor property, real estate, and building construction yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2018-2020. Sampel yang digunakan dalam penelitian ini sebanyak 41 perusahaan selama 3 tahun dengan total 123 data pengamatan. Teknik analisis yang digunakan adalah analisis deskriptif dan analisis regresi logistik. Hasil penelitian ini menunjukkan bahwa ukuran komite audit, frekuensi rapat komite audit, dan Chief Executive Officer (CEO) Gender secara simultan berpengaruh terhadap ketepatan waktu pelaporan keuangan. Ukuran komite audit, frekuensi rapat komite audit, dan Chief Executive Officer (CEO) Gender secara parsial tidak berpengaruh terhadap ketepatan waktu pelaporan keuangan.
Lithium-induced parkinsonism associated with vocal cord paralysis: an atypical presentation
Authors:   Department of Psychiatry, Unit of Psychiatric Disorders in Medical Complex Pathologies, University of Pisa, Italy, Raia Accursio , Montalbano Clara ,   Department of Psychiatry, Unit of Psychiatric Disorders in Medical Complex Pathologies, University of Pisa, Italy, Caruso Valerio ,   Department of Psychiatry, Unit of Psychiatric Disorders in Medical Complex Pathologies, University of Pisa, Italy
Published: July 2023

Drug-induced parkinsonism has been commonly studied and discussed regarding antipsychotic agents, but lithium-induced parkinsonism should also be considered when patients present with parkinsonian symptoms and chronic lithium use. There are several reports of parkinsonism arising during lithium administration and regressing following its reduction or discontinuation. Our case is, to date, the first case in the literature in which vocal cord paralysis occurred as the first symptom of lithium-induced parkinsonism, contributing to confuse doctors and patients and to delay diagnosis and treatment. In our clinical case prompt withdrawal of lithium and its reintroduction at lower doses led to complete resolution of this disabling clinical presentation. This report emphasizes the importance of careful monitoring of lithium levels, especially in elderly subjects, and the need to consider lithium-induced parkinsonism even when unusual motor symptoms appear in chronic lithium users.
ANATOMIA HUMANA: Um livro para estudantes, futuros Educadores e Professores do 1.º e 2.º CEB
Authors:   Universidade do Algarve, Rocha Rute
Published: July 2023

Anatomia tem origem na palavra grega «anatoma», que significa dissecação, a arte de dissecar as partes do corpo para estudar a sua estrutura. Neste livro apresentam-se fotografias relativas à anatomia de alguns órgãos dissecados em sala de aula, da unidade curricular de Biologia Humana da Licenciatura em Educação Básica. Para além dos registos fotográficos, pretende-se que este livro constitua um complemento ao estudo da anatomia humana e sua fisiologia. Para que o referido estudo seja eficaz, aconselha-se a consulta de diversas obras/livros, para a compreensão aprofundada do funcionamento dos órgãos, aparelhos e sistemas humanos. Para além das fotografias, apresentam-se caixas com aspetos a ter em consideração nas observações anatómicas.
Effect of Cognitive Restructuring to Increase Students' Academic Resiliense
Authors: Magdalena Olga Maria , Durrotunnisa
Published: July 2023

The main problem in this research is the low academic resilience of students, which is characterized by difficulties in self-adjustment when studying during a pandemic. This study aims to improve students' academic resilience through group counseling services with cognitive restructuring techniques. This type of research is a quasi-experimental one group pre-test post-test design. This research was conducted four times with the number of research subjects 8 students. The instrument in this study used an academic resilience scale. Data were processed and analyzed descriptively and inferentially using the Wilcoxon sign rank test formula. The results of descriptive analysis show that before participating in group counseling services cognitive restructuring techniques of the 8 students studied, there were 6 students who had low academic resilience and 2 students who had moderate academic resilience. After participating in group counseling services, cognitive restructuring techniques have increased, namely 6 students who have high academic resilience and 2 students have moderate academic resilience. The results of inferential analysis show that there is a significant difference in students' academic resilience between before and after being given group counseling services using cognitive restructuring techniques. The effect of cognitive restructuring technique group counseling on students' academic resilience. The implication of the research is that resilience can be developed in counselees by applying all the stages of counseling that have been determined, starting from recognizing the problem, changing negative thoughts to a more positive direction as a solution to the problems faced.
IMPLEMENTASI K-MEANS DALAM PENGELOMPOKAN PENYEBARAN PENYAKIT DBD DI JAWA BARAT
Authors: Rosiana Puput Silva , Mohsa Alpin Apriliansyah , Umaidah Yuyun
Published: July 2023

Penyakit menular ini disebut penyakit demam berdarah atau DBD adalah penyakit infeksi virus aedes aegyppti yang akut yang disebabkan oleh virus dengue yang di tularkan melalui gigitan pada nyamuk. Berdasarkan tahun 2020, terjadi 24 ribu kasus infeksi DBD di Provinsi Jawa Barat. Maka dari itu, pada penelitian ini mengenai penyakit atau infeksi virus DBD pada Provinsi Jawa Barat menjadi sangat penting untuk dilakukan penelitian untuk menemukan pola penyebaran pada kasus ini. Data yang digunakan dalam penelitian ini berasal dari Open Data Jawa Barat, yaitu portal resmi data terbuka milik Pemerintah Provinsi Jawa Barat. Data yang diambil adalah data yang terkait dengan kasus infeksi Demam Berdarah Dengue (DBD) berdasarkan provinsi dari tahun 2014 hingga 2021.  Open Data Jawa Barat menyediakan data dari Perangkat Daerah di lingkungan Pemerintah Provinsi Jawa Barat guna memenuhi kebutuhan masyarakat akan data yang akurat dan terkini.   Kemudian data ini akan diseleksi, dari total terdapat 9 atribut hanya 3 atribut saja yang dipilih yaitu nama kabupaten kota, jumlah kasus, dan tahun. Jumlah anggota cluster 0 menunjukan 139 data dan kriteria rendah 139 data, lalu untuk cluster 1 menunjukan 33 data dengan kriteria tinggi 33 data, dan untuk cluster 2 memiliki 260 data dengan kriteria sedang 260 data. Evaluasi  yang digunakan yaitu dengan teknik silhouette score dengan hasil score 0,5931974349414901.
The Impact of Financial Ratios on Return on Asset, Moderated by Total Assets: A Study on Pharmaceutical Companies in Indonesia
Authors: Hermawan Whisnu Dhani , Ishak Gos , Budiantoro Anandha
Published: July 2023

This research aims to examine the relationship between independent variables, including Debt to Assets Ratio, Debt to Equity Ratio, Current Ratio, Inventory Turnover Ratio, and Accounts Receivable Ratio, and the dependent variable of Return on Assets. The moderating variable in this study is Total Assets. The research was conducted on pharmaceutical companies listed on the Indonesia Stock Exchange (IDX) from 2019 to 2022, a period marked by the Covid-19 health outbreak. This study explores whether the outbreak has impacted the pharmaceutical sector, which is integral to disease prevention and treatment of Covid-19. The findings indicate that most independent variables have an insignificant relationship with the dependent variable of Return on Assets, which is moderated by firm size. However, there is a significant positive relationship between Inventory Turnover and Return on Assets, moderated by firm size. These results suggest that Inventory Turnover is a crucial factor for pharmaceutical companies to consider when aiming to improve their Return on Assets. Overall, this study offers valuable insights into the relationship between various financial ratios and Return on Assets for pharmaceutical companies during a period of unprecedented global health crisis. The results provide a basis for future research in this field and can inform decision-making for pharmaceutical firms looking to improve their financial performance.