bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of adverse reactions among antipsychotic drugs using the Korean Adverse Event Reporting System database from 2010 to 2019
Authors: Oh Sanghoon , Byeon Sun-ju , Chung Soo Jie
Published: June 2022

Background:

Retrospective studies using spontaneous reporting system databases have provided a great understanding of adverse drug reactions (ADRs) in the real world, complementing the data obtained from randomized controlled trials. However, there have been few reports on large-scale epidemiological studies on the adverse effects of antipsychotics in Asia.

Aim:

This study aimed to investigate the characteristics of antipsychotic ADRs using a nationwide pharmacovigilance database.

Methods:

Data were collected from the Korea Adverse Event Reporting System database between 2010 and 2019. The study subjects were selected using the International Classification of Disease codes for diseases related to psychosis and Electronic Data Interchange codes for amisulpride, aripiprazole, clozapine, haloperidol, olanzapine, paliperidone, quetiapine, risperidone, and ziprasidone. The causality assessment of “possible,” “probable,” or “certain” by the World Health Organization–Uppsala Monitoring Center System causality category was selected. All data were descriptively analyzed.

Results:

In total, 5067 adverse events associated with antipsychotic drugs were reported. The antipsychotics that commonly resulted in ADRs were quetiapine (47.7%), olanzapine (11.3%), and clozapine (10.7%). Serious ADRs were most commonly observed with clozapine. Gastrointestinal and central nervous system problems occurred within a month when ADRs were classified according to the time of onset. In contrast, metabolic and bone marrow-related symptoms occurred after long-term use. Sedation and nausea were the most common ADRs in children and adolescents, whereas constipation and dizziness were common in adults and the elderly.

Conclusions:

This study extends our knowledge of antipsychotic ADRs in the Asian population.
Pre-Prison and Indigenous Predictors of Institutional Misconduct
Authors: Quick Ellen , Iselin Anne-Marie , DeCoster Jamie , Fasone Hailey
Published: June 2022

This study prospectively predicted institutional misconduct over a 34-month period using pre-prison factors—intrinsic characteristics an individual brings into prison—stemming from importation theory and indigenous factors—prison environment factors that affect an incarcerated adult—stemming from deprivation theory. Participants were 114 male and female incarcerated adults. Poisson regressions predicting the number of institutional infractions partially supported each of the models tested. Both pre-prison factors of self-regulatory mode and perceived social support were related to infractions but in unique ways. For regulatory mode, locomotion was positively, and assessment negatively associated with misconduct. For social support, perceptions of guidance received within a reliable alliance with others were negatively related to misconduct, whereas perceptions of guidance without that alliance were positively related to institutional misconduct. Of our indigenous factors, sentence length was negatively related to misconduct, whereas custody level was unrelated to misconduct. Implications of the findings and directions for future research are discussed.
Treatment Experiences Among Intimate Partner Violence Perpetrators: A Qualitative Analysis
Authors: Arvidsson Moa , Caman Shilan
Published: June 2022

Intimate partner violence (IPV) is a global and widespread public health issue. Knowledge on what promotes individual-level reductions in risk for IPV recidivism is limited. In order to explore how group therapy influences the ability to obtain and sustain change, the objectives were to explore how IPV perpetrators make sense of and think about their experiences of group therapy and what their experiences are regarding needs of treatment for IPV perpetration. Six semi-structured interviews were conducted and analyzed with the qualitative method Interpretative Phenomenological Analysis. Two main themes were identified; “Experiences in group therapy” (subthemes: Ultimatum as a turning point; The guys as a powerful tool for change and Unfinished ending) and “Treatment needs” (subthemes: Violence as an addiction and Weakness as a strength). The findings highlight that group therapy is experienced positively, as well as difficulties that constitute obstacles, and need of further support after ending treatment.
Breastfeeding Practices Before and During the COVID-19 Pandemic in Fortaleza, Northeastern Brazil
Authors: Farías-Antúnez Simone , Correia Luciano Lima , Araújo David Augusto Batista Sá , Penna Ana Luiza , de Sousa Geziel dos Santos , Silva Anamaria Cavalcante e , Campos Jocileide Sales , Rocha Hermano Alexandre Lima , Aquino Camila Machado de , Castro Marcia C. , Tavares Machado Márcia Maria
Published: June 2022

Background:

Physical distancing associated with the COVID-19 pandemic may lead to suboptimal maternal mental health, social support after birth, and infant feeding practices.

Research Aims:

To compare breastfeeding prevalence in participants who were pregnant at a time when strict physical distancing measures were imposed in Fortaleza, the capital of Ceará state, Brazil, with the pre-pandemic breastfeeding levels, and to assess the association of breastfeeding prevalence with maternal common mental disorders, and sociodemographic and health predictors.

Method:

A cross-sectional prospective two-group comparison design using two population-based surveys was carried out in Fortaleza before and after the pandemic. Participants ( n = 351) who had a live birth in Fortaleza in July or August 2020, and participants ( n = 222) who had a child younger than 12 months in 2017 were surveyed. Crude and adjusted multinomial logistic regressions with robust variance were used to estimate risk ratios and 95% confidence intervals (CI).

Results:

Similar prevalence of exclusive breastfeeding were observed in 2021 (8.1%) and 2017 (8.5%; p = .790). An increase in predominant (2.2% vs. 13.4%; p < .001) and a decrease in complementary breastfeeding (64.0% vs. 48.4%; p = .037) was observed in 2021, compared to 2017. The prevalence of maternal common mental disorders also increased in 2021 (17.6% vs. 32.5%, p < .001). No statistically significant associations were found between breastfeeding patterns, maternal common mental disorders, and other predictors in 2017 or 2021.

Conclusions:

Participants who delivered during the COVID-19 pandemic delayed solid foods introduction and breastfed predominantly longer than participants during the pre-pandemic period. While common mental disorders significantly increased, they were not associated with differences in breastfeeding.
‘They Exist but They Don’t Exist’: Personal Assistants Supporting Physically Disabled People in the Workplace
Authors: Maddison Jane , Brooks Jenni , Graham Katherine , Birks Yvonne
Published: June 2022

Employment rates in England for disabled people are persistently lower than for non-disabled people. Support from a Workplace Personal Assistant is one way of narrowing this gap. Personal assistance is an empowerment-driven model in which the disabled person controls their support: who provides it, when, how and where. Previous research has focused on the personal assistant role in the home setting. This article draws on data from 32 qualitative interviews in the first UK study to explore personal assistance in the workplace for people with physical and /or sensory impairments. To maintain their enabling role in this external setting, Workplace Personal Assistants needed to strive for occupational invisibility when among the disabled workers’ colleagues: to ‘exist but not exist’. This article examines the Workplace Personal Assistant role as invisible work, applying Hatton’s conceptual framework. The analysis contributes to understanding of workplace personal assistance and ways in which mechanisms can intersect to produce multiple invisibility.
Equivalent static loads for double-layered domes supported by multistorey buckling-restrained braced frames
Authors: Nair Deepshikha , Terazawa Yuki , Takeuchi Toru
Published: June 2022

Curved gridshells are excited not only in the horizontal direction but also experience large anti-symmetric vertical accelerations when subjected to horizontal earthquake ground motions. In addition to the coupled response, gridshells exhibit closely spaced modes and substructure-roof interaction. Nevertheless, previous studies have proposed elastic horizontal and vertical equivalent static seismic forces considering these complex dynamic response characteristics. These are determined from the input horizontal acceleration at the substructure’s roof level, an assumed acceleration distribution, nodal roof masses and amplification factors derived from the dynamic characteristics of the dome and substructure. To extend this methodology to nonlinear substructures with displacement-dependent damping devices, this paper investigates the applicability of ductility reduction factors (or Rμ factors) to estimate the inelastic response spectra and an alternative equivalent linearisation approach to compute the peak horizontal acceleration of multistorey substructures with buckling-restrained braces. This is achieved by modelling the curved roof as a rigid mass for the substructure model, and using its idealised base shear-roof displacement relationship obtained from modal pushover analyses. The peak horizontal acceleration of the substructure is then used to obtain the equivalent static loads of the curved roof using amplification factors, and the accuracies are verified against the results from nonlinear response history analyses. It was confirmed that the Rμ [Formula: see text]factors combined with the roof amplification factors provide a simple way to estimate the peak roof response with sufficient accuracy for preliminary design of domes with multistorey substructures having low post-yield stiffness.
Book review: Selma James, Margaret Prescod, Nina Lopez, Our Time Is Now: Sex, Race, Class and Caring for People and Planet
Authors: Jain Shraddha
Published: June 2022

Selma James, Margaret Prescod, Nina Lopez, Our Time Is Now: Sex, Race, Class and Caring for People and Planet, PM Press, 2021, 256 pp., ₹1,407. ISBN: 9781629638386 (Paperback).
Malignant Tumors of the Foot and Ankle
Authors: Karaca Mustafa Onur , Başarır Kerem , Merter Abdullah , Acar Erdinç , Özbek Emre Anıl , Özyıldıran Mustafa , Yıldız Hüseyin Yusuf
Published: June 2022

Background:

Surgical treatment is usually required for malignant foot and ankle tumors. In this study, we sought to review factors in treatment that may be associated with morbidity and mortality.

Methods:

All malignant foot and ankle tumors at our institution between April 1988 and April 2018 were retrospectively reviewed. The surgical modalities used and clinical outcomes of patients according to the anatomic location (Kirby zone) and clinical stage (Enneking system) of each tumor were described. Extent of surgical resection required, recurrence, and death rates were assessed.

Results:

Between April 1988 and April 2018, 80 patients with malignant tumors of the foot and ankle were treated at out institution. Mean age of patients was 42.6 (range, 3-89) years. Mean follow-up was 30.2 months (range, 24-120). Tumors were primary in 75 patients (94%) and metastatic from another organ in 5 patients (6%). Tumors originated from bone in 18 patients (22%) and from soft tissue in 63 patients (78%). Synovial sarcoma was the most common soft tissue tumor, and osteosarcoma was the most common osseous tumor. All patients had surgery to resect their tumor. Twenty-one (26%) had unplanned surgical procedures without initial biopsy at an outside institution prior to referral. Those patients were more likely to be treated with amputation or wide excison and free flap surgery ( P < .01). The recurrence rate was 50% for the unplanned surgery group and 22% for the planned surgery group. Mortality rate was 10% for the unplanned group and 6% for the planned group. The recurrence and mortality rate was higher in the unplanned group ( P = .03).

Conclusion:

Our study suggests that unplanned initial surgeries are associated with higher recurrence and mortality rates and reinforces the notion that these patients should be referred for treatment at a center with specialized expertise in tumor management.

Level of Evidence:

Level, IV, retrospective case series.
Progress Toward a Multiomic Understanding of Traumatic Brain Injury: A Review
Authors: Kocheril Philip A , Moore Shepard C , Lenz Kiersten D , Mukundan Harshini , Lilley Laura M
Published: June 2022

Traumatic brain injury (TBI) is not a single disease state but describes an array of conditions associated with insult or injury to the brain. While some individuals with TBI recover within a few days or months, others present with persistent symptoms that can cause disability, neuropsychological trauma, and even death. Understanding, diagnosing, and treating TBI is extremely complex for many reasons, including the variable biomechanics of head impact, differences in severity and location of injury, and individual patient characteristics. Because of these confounding factors, the development of reliable diagnostics and targeted treatments for brain injury remains elusive. We argue that the development of effective diagnostic and therapeutic strategies for TBI requires a deep understanding of human neurophysiology at the molecular level and that the framework of multiomics may provide some effective solutions for the diagnosis and treatment of this challenging condition. To this end, we present here a comprehensive review of TBI biomarker candidates from across the multiomic disciplines and compare them with known signatures associated with other neuropsychological conditions, including Alzheimer’s disease and Parkinson’s disease. We believe that this integrated view will facilitate a deeper understanding of the pathophysiology of TBI and its potential links to other neurological diseases.
Erector spinae plane versus paravertebral catheter techniques for rib fracture analgesia: A pilot matched cohort study
Authors: Murray Nathan , Swierczek Justin , Riley Brooke , Mitchell Andrew , Abi-fares Catherine , Basson Willem , Anstey Chris , White Leigh
Published: June 2022

Background

Numerous regional techniques are available to provide analgesia and reduce complications related to rib fractures. There is a paucity of evidence comparing the efficacy of these techniques. This pilot study aims to assess the efficacy of erector spinae plane block (ESPB) versus paravertebral block (PVB) catheters for rib fracture analgesia.

Methods

Patients who received either an ESPB or PVB catheter for rib fracture analgesia over the study period (April 2017 to September 2020) were eligible for inclusion. Patients were matched based on demographics and injury characteristics. Outcomes of interest included pre and post catheter-insertion numerical pain scores at rest and with movement, and time to rescue analgesia following catheter insertion.

Results

Thirty-four matched patients were included in this study. Pain scores at rest and with movement were significantly reduced in both groups. There were no statistically significant differences in post-block pain scores or time to rescue analgesia between the two groups. Fifteen (88.2%) of those in both groups had a documented subjective improvement in pain, inspiratory effort or cough strength.

Conclusion

This pilot study is the first to show that the recently described ESPB technique provides non-inferior analgesia compared to PVB for the management of rib fractures. Both techniques were effective in reducing pain scores and had similar times to rescue analgesia. This study supports claim that the ESPB is an effective alternative to traditional regional techniques in the management of rib fractures.
Viral paradox: The intersection of “me too” and #MeToo
Authors: Boyd Alicia , McEwan Bree
Published: June 2022

Scholarship on #MeToo has examined the feminist underpinnings of the movement and affordances of digital platforms to create space for telling stories of sexual harassment and violence. This essay makes a different contribution, in that we seek to understand the impact of the viral version of #MeToo on the established primarily Black community developed by Tarana Burke. In this essay, we use the framework of intersectionality and organizational paradox to examine the differences in the social construction of the two versions of the movement. The framework of intersectionality allows us to examine how the viral version of #MeToo perpetuated by Alyssa Milano reified the social construction of inequalities and interlocking systems of oppression for Black and other women of color. The article examines the effects of Milano’s entrance into the “me too” space on the community built through Burke’s “me too” movement. We identify an illumination/occlusion paradox that creates the illusion of inclusivity, creates difficulty in community boundary management, and allows for outsider gaze into a previously safe space. We argue for moving beyond the considerations of assigning credit for the movement and instead consider the impacts of the paradox of the original community experiencing erasure through the abrupt and swift increased visibility of the hashtag.
All the lonely people: Effects of social isolation on self-disclosure of loneliness on Twitter
Authors: Hommadova Lu Anya , Mejova Yelena
Published: June 2022

This study explores the effect of unprecedented mass isolation during COVID-19 lockdowns through the lens of self-disclosure of loneliness on Twitter. Using a dataset of 30 million public tweets, we use machine learning to identify tweets that contain self-disclosure of loneliness. We find that thousands more people turned to Twitter to express their loneliness during the lockdowns; however, this effect normalized within a month, demonstrating the “ordinization” effect on a collective level. Furthermore, lockdown brought a marked shift in the weekly timings of posting and a change in the accompanying emotions, which were more positive and other-focused. Finally, based on a qualitative analysis, we propose an updated typology of loneliness that captures the possibilities offered by the affordances of social media. Our findings illustrate the profound effect lockdowns had on the societal psychological state and emphasize the importance of mental health resources during extreme and isolating events.
Love as an energizing feature of action research for territorial development
Authors: Larrea Miren
Published: June 2022

In the face of today’s urgent societal challenges, there are constant calls for regional governments to respond to them. Yet, policies, including those developed through action research, appear to be transforming too slowly. This paper focuses on love as a methodological dimension of action research that can energize these responses. One of the main features of love is that it requires mastering the interplay between reason and emotion, and I use art-based action research as a vehicle to explore this interplay. More specifically, my data in this paper are the poems I wrote when I participated in an experiment led by an artist on social media. The discussion of the case focuses on how we can use the lessons learnt in the experiment to integrate love in action research for territorial development.
“World-Informed” Neuroscience for Diversity and Inclusion: An Organizational Change in Cognitive Sciences
Authors: Kasai Kiyoto , Kumagaya Shin-ichiro , Takahashi Yusuke , Sawai Yutaka , Uno Akito , Kumakura Yousuke , Yamagishi Mika , Kanehara Akiko , Morita Kentaro , Tada Mariko , Satomura Yoshihiro , Okada Naohiro , Koike Shinsuke , Yagishita Sho
Published: June 2022

By nature, humans are “ tojisha (participating subjects/player–witnesses)” who encounter an unpredictable real world. An important characteristic of the relationship between the individual brain and the world is that it creates a loop of interaction and mutual formation. However, cognitive sciences have traditionally been based on a model that treats the world as a given constant. We propose incorporating the interaction loop into this model to create “world-informed neuroscience (WIN)”. Based on co-productive research with people with minority characteristics that do not match the world, we hypothesize that the tojisha and the world interact in a two-dimensional way of rule-based and story-based. By defining the cognitive process of becoming tojisha in this way, it is possible to contribute to the various issues of the real world and diversity and inclusion through the integration of the humanities and sciences. The critical role of the brain dopamine system as a basis for brain–world interaction and the importance of research on urbanicity and adolescent development as examples of the application of WIN were discussed. The promotion of these studies will require bidirectional translation between human population science and animal cognitive neuroscience. We propose that the social model of disability should be incorporated into cognitive sciences, and that disability-informed innovation is needed to identify how social factors are involved in mismatches that are difficult to visualize. To promote WIN to ultimately contribute to a diverse and inclusive society, co-production of research from the initial stage of research design should be a baseline requirement.
Can Diffusion Tensor Imaging Apparent Diffusion Coefficient Diagnose Carpal Tunnel Syndrome? A Systematic Review and Meta-Analysis
Authors: Evans Adam G. , Morgan Maurice D. , Aiken Benjamin A. , Assi Patrick E. , Joseph Jeremy T. , Kesayan Tigran , Mioton Lauren M. , Esteve Isaac V. M. , Hill J. Bradford , Thayer Wesley P. , Al Kassis Salam
Published: June 2022

Magnetic resonance diffusion tensor imaging (DTI) can detect microstructural changes in peripheral nerves. Studies have reported that the median nerve apparent diffusion coefficient (ADC), a quantification of water molecule diffusion direction, is sensitive in diagnosing carpal tunnel syndrome (CTS). Five databases were searched for studies using ADC to investigate CTS. A﻿pparent diffusion coefficient (measured in mm2/s) were pooled in random-effects meta-analyses. Twenty-two studies met criteria yielding 592 patients with CTS and 414 controls. Median nerve ADC were measured at the level of the distal radioulnar joint (CTS ADC: 1.11, 95% CI: 1.07-1.15, I2 = 54%; control ADC: 1.04, 95% CI: 1.01-1.07, I2 = 57%), pisiform (CTS ADC: 1.39, 95% CI: 1.37-1.42, I2 = 0%; control ADC: 1.27, 95% CI: 1.23-1.31, I2 = 59%), hamate (CTS ADC: 1.40, 95% CI: 1.36-1.43, I2 = 58%; control ADC: 1.27, 95% CI: 1.25-1.28, I2 = 47%), and as an combination of several measurements (CTS ADC: 1.40, 95% CI: 1.37-1.47, I2 = 100%; control ADC: 1.39, 95% CI: 1.24-1.53, I2 = 100%). Median nerve ADC is decreased in individuals with CTS compared to controls at the levels of the hamate and pisiform. ADC cut-offs to diagnose CTS should be established according to these anatomic levels and can be improved through additional studies that include use of a wrist coil.
Participation of children with and without disabilities in home, school, and community in Hong Kong: A 2-year longitudinal study
Authors: Choi Pak-Ho , Ma Pui-Sze , Mak Wai-Ying , Mok Nga-Pan , Cynthia Lai Yuen Yi , Chien Chi-Wen
Published: June 2022

Background

Children with disabilities are reported to participate less in activities than their typically developing peers. However, owing to limited longitudinal studies, improvements or deteriorations in their participation over time remain unclear. No studies were also conducted in Hong Kong to describe children’s activity participation over time.

Aim

To investigate the changes in participation patterns of Hong Kong children with and without disabilities.

Methods

Thirty-four children with disabilities and 138 without disabilities were recruited from four schools. Their parents completed the Participation and Environment Measure for Children and Youth twice over 2 years.

Results

After 2 years, both groups of children were found to engage more frequently in using electronic devices and less frequently in indoor play activities/games at home. They also participated more often in school extra-curriculum activities, events and field trips. However, the frequency of community activities remained relatively stable in the two groups. No changes in their levels of involvement in almost of home, school and community activities were identified.

Conclusion

The findings of increased participation in some home and school activities over time are encouraging. However, stable or possibly decreased participation of children with disabilities in other activities requires further efforts in promoting their participation.
More than just an immigrant: The semantic patterns of (im)migrant/predicate-pairings in news stories about Mexican and Central American (im)migrants to the USA. A corpus-assisted discourse study
Authors: Dyvik Cardona Margrete
Published: June 2022

In this paper we explore how some of the largest US-newspapers linguistically frame immigrants to the USA in articles about Mexican and Central American immigrants. Specifically, it is a corpus-assisted discourse study which examines the frequency of different semantic predicate-types with (im)migrant subjects and (im)migrant by-agents in the quest for underlying positive or negative biases. We wish to ascertain what activities (im)migrants are presented as taking part in, principally as agents. The analysis shows that more than half of the (im)migrant/predicate-pairings reflect the dictionary definitions of (im)migrant. However, immigrants are described as illegal 66% of the times that their location is mentioned with an immigrant/predicate-pairing. The non-definition-confirming pairings also show evidence of a negative framing of immigrants, but not of migrants. Furthermore, immigrants are more often than migrants cast as agents of activities that do not simply reiterate their status as (im)migrants. Finally, we found evidence of the Negation Bias in the immigrant/predicate-pairings.
Chinese media representations of tongzhi (2009–2019)
Authors: Zhang Ke , Lu Chao , Zhang Jingyuan
Published: June 2022

Recent years have witnessed an increasing academic interest in Chinese homosexuality; however, linguistic-oriented research on this topic is scant and multimodal inquiry on it is even rarer. To address the gap, this article conducts a discourse analysis of how tongzhi in mainland China are represented by news media. Specifically, we examine both linguistic and visual representations of tongzhi by utilizing two influential English-language newspapers in mainland China published between 2009 and 2019. Our data consist of 221 news articles totaling 117,407 words; 44 of the articles are accompanied with pictures. Methodologically, we draw on Halliday’s transitivity structure coupled with van Leeuwen’s classification of social actors. Our findings reveal that Chinese tongzhi are mainly represented in a negative fashion, and that there is little positive news representation of this invisible community. In addition, socio-cultural factors contributing to media representations of Chinese tongzhi are considered.
The Impact of History Textbooks on Young Chinese People's Understanding of the Past: A Social Media Analysis
Authors: Jackson Isabella , Du Siyi
Published: June 2022

History textbooks are the only history books that the majority of people read in their lives. This article investigates the impact of history textbooks on young Chinese people's understanding of their nation's modern history, as revealed on the popular microblogging site Sina Weibo. We analysed posts related to history textbooks and their representations of three contentious turning points in the communist historical narrative: the May Fourth Movement of 1919, the nationalist assault on the communists in 1927, and the Yan’an Rectification Movement of 1942. Widespread engagement with and recollection of history textbook content indicates a substantial impact of these textbooks on people's understanding of the past and a willingness to relate that past to the present. Responses to textbooks vary widely, from acceptance of the textbook narrative and the expression of strong patriotic and emotional connections to the past as presented in textbooks to open and angry critique.
A Framework for Evaluation and Improvement of Open Government Data Quality: Application to the Western Balkans National Open Data Portals
Authors: Raca Vigan , Velinov Goran , Dzalev Stefan , Kon-Popovska Margita
Published: June 2022

Open Government Data (OGD) has become a widely employed tool by governments around the world to promote transparent and accountable policy-making. In the context of societal actors’ ability to reuse such data, one of the most important features of ODG is its quality. Thus, through this research, we aim to address the level of data quality by introducing a new framework that constantly monitors and evaluates the OGD quality of Western Balkan (WB) National Open Data Portals. The advantage of the proposed framework is the integration on the portal level enabling information exposure about the quality dimension at any time. An additional value of the framework is the ability to provide recommendations with the intention of improving quality issues. The applicability and findings of the proposed framework are not limited to the WB and once contextualized that could be applied to other countries in the Eastern European that face similar data quality challenges.
The Indonesian Government Capacity in Responding to the COVID-19 Impacts on the Creative Economy Sector
Authors: Rosyadi Slamet , Sabiq Ahmad , Ahmad Abdul Aziz , Nuryanti
Published: June 2022

Extensive research has been carried out on government capacity to cope with the pandemic. However, little study on this issue exists examining it in the context of the creative economy sector. It has been argued that the successful organizations to address changes in the environment are determined by their organizational capacity. In this paper, we analyze the Indonesian government’s capacity to recover the creative economy sector during the first year of the COVID-19 pandemic. The qualitative content analysis method and key informant interviews were undertaken to understand government capacity. The paper extended the RISE (resilience, intention, sustain, and endurance) model to understand the process of government actions in recovering the creative economy sector from the adverse effects of the COVID-19 pandemic. The RISE model portrays the government’s capacity to respond to the hostile and uncertain environment through tax and loan relaxation, social and health assistance, and capacity building. This paper provides valuable insight into public administration by highlighting government responses to the global pandemic. By analyzing four stages of government actions in restoring the creative economy sector, this study shows that the expected outcomes are far from satisfactory. The government intervention during the first year of the COVID-19 pandemic becomes ineffective because the government is weak in preparing the creative economy recovery policies according to the needs of creative economy actors and accurate data. These findings suggest that the central and local government should improve their collaborative capacity to upgrade the creative economy recovery programs according to the local aspiration.
Corticosteroids Use and Incidence of Severe Infections in People Living with HIV Compared to a Matched Population
Authors: Damba Joseph Junior , Laskine Mikhael , Peet Marc Messier , Jin Yulan , Sinyavskaya Liliya , Durand Madeleine
Published: June 2022

Background:

People living with HIV (PLWH) have been shown to have an increased risk of autoimmune diseases. Corticosteroids are the cornerstone of autoimmune diseases treatment, but their use is associated with an increased risk of infections. It is unclear how HIV status affects the risk of infection associated with corticosteroids use.

Methods:

We conducted a retrospective cohort study from 1991 to 2011, using a medico-administrative database from Quebec. Medical billing codes were used to identify PLWH, and we matched them on age, sex, and index date with up to 4 HIV-negative controls. The exposure of interest was the use of corticosteroids, defined as a systemic corticosteroid dispensation lasting at least 20 days. The outcome of interest was hospitalization for severe infection. Crude and adjusted incidence rates ratios of infection were obtained using a random effect Poisson model, and results were stratified by HIV status.

Results:

In total, 4798 PLWH were matched to 17 644 HIV-negative controls, among which 1083 (22.6%) PLWH and 1854 (10.5%) HIV-negative controls received at least one course of corticosteroid. The mean duration of corticosteroids use was 4 ± 4.4 months in PLWH and 1.6 ± 5.5 months in HIV-negative controls. The incidence rate ratio (IRR) for infections associated with corticosteroids use was 2.49[1.71–3.60] in PLWH and 1.32[0.71–2.47] in HIV-negative controls (P value for interaction 0.18). The most frequent infections were pulmonary infections (50.4%), followed by urinary tract infections (26%) and opportunistic infections (10.5%).

Conclusion:

Although our interaction term did not reach significance, the increased risk of infection associated with corticosteroids use was more pronounced in PLWH. However, further research with contemporary data is warranted to confirm if the risk associated with corticosteroids use remains high in PLWH with well-controlled HIV infection.
Epidemiology of Pediatric Gymnastics Injuries Reported in US Emergency Departments: Sex- and Age-Based Injury Patterns
Authors: Tisano Breann , Zynda Aaron J. , Ellis Henry B. , Wilson Philip L.
Published: June 2022

Background:

Despite increasing participation rates in youth gymnastics, the majority of epidemiologic literature focuses on older elite athletes or stratifies athletes by level of competition.

Hypothesis:

The authors hypothesized that sex- and age-based patterns in youth gymnastics–related injuries exist, which are otherwise overlooked in an unstratified population.

Study Design:

Descriptive epidemiology study.

Methods:

Publicly available injury data from the National Electronic Injury Surveillance System were collected on pediatric gymnastics injuries presenting to emergency departments in the United States. Participation data from the National Sporting Goods Association were used to calculate national injury incidence rates in 7- to 11-year-olds (childhood) and 12- to 17-year-olds (adolescence) from January 1, 2012, to December 31, 2018. Z tests were conducted for the comparison of injury rates between girls and boys within each age group and for overall injury rate across age groups.

Results:

Girls participated in gymnastics at a frequency 6.5 times that of boys in childhood and 13.5 times that of boys in adolescence. An estimated 72,542 youth gymnastics–related injuries were reported in US emergency departments each year. A large proportion (61.3%) occurred in childhood, with female predominance in both age groups. Overall, there was no difference in weighted annual injury rate (injuries per 100,000 athlete-days per year) by age group (6.9 [childhood] vs 8.8 [adolescence]; P = .19) or sex (7.4 [girls] vs 8.1 [boys]; P = .65). In adolescence, boys were more likely than girls to experience injury (16.47 vs 8.2; P = .003). Wrist and lower arm fractures were more common in childhood than adolescence (1.07 vs 0.43; P = .002) and specifically in girls (childhood vs adolescence, 1.06 vs 0.37; P = .001). Ankle injuries and concussions were more common in adolescence vs childhood ( P = .01 and .0002).

Conclusion:

Upper extremity injuries predominated among childhood gymnasts, particularly girls. In adolescence, girls and boys experienced increases in concussions and foot and ankle injuries. Although representing a lower overall number of training gymnasts as compared with girls, adolescent boys experience a higher rate of injuries overall.
Point of care ultrasound as initial diagnostic tool in acute dyspnea patients in the emergency department of a tertiary care center: diagnostic accuracy study
Authors: Baid Himanshi , Vempalli Nagasubramanyam , Kumar Subodh , Arora Poonam , Walia Rohit , Chauhan Udit , Shukla Krishna , Verma Aakash , Chawang Hannah , Agarwal Disha
Published: June 2022

Background

Dyspnea is one of the common symptoms patients present to the emergency department (ED). The broad spectrum of differentials often requires laboratory and radiological testing in addition to clinical evaluation, causing unnecessary delay. Point of care ultrasound (PoCUS) has shown promising results in accurately diagnosing patients with dyspnea, thus, becoming a popular tool in ED while saving time and maintaining safety standards. Our study aimed to determine the utilization of point of care ultrasound in patients with acute dyspnea as an initial diagnostic tool in our settings.

Methodology

The study was conducted at the emergency department of a tertiary healthcare center in Northern India. Adult patients presenting with acute dyspnea were prospectively enrolled. They were clinically evaluated and necessarily investigated, and a provisional diagnosis was made. Another EP, trained in PoCUS, performed the scan, blinded to the laboratory investigations (not the clinical parameters), and made a PoCUS diagnosis. Our gold standard was the final composite diagnosis made by two Emergency Medicine consultants (who had access to all investigations). Accuracy and concordance of the ultrasound diagnosis to the final composite diagnosis were calculated. The time to formulate a PoCUS diagnosis and final composite diagnosis was compared.

Results

Two hundred thirty-seven patients were enrolled. The PoCUS and final composite diagnosis showed good concordance (κ = 0.668). PoCUS showed a high sensitivity for acute pulmonary edema, pleural effusion, pneumothorax, pneumonia, pericardial effusion, and low sensitivity for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute respiratory distress syndrome (ARDS)/acute lung injury (ALI). High overall specificity was seen. A high positive predictive value for all except left ventricular dysfunction, pericardial effusion, non-cardiopulmonary causes of dyspnea, and a low negative predictive value was seen for pneumonia. The median time to make a PoCUS diagnosis was 16 (5–264) min compared to the 170 (8–1346) min taken for the final composite diagnosis. Thus, time was significantly lower for PoCUS diagnosis (p value <0.001).

Conclusion

By combining the overall accuracy of PoCUS, the concordance with the final composite diagnosis, and the statistically significant reduction in time taken to formulate the diagnosis, PoCUS shows immense promise as an initial diagnostic tool that may expedite the decision-making in ED for patients’ prompt management and disposition with reliable accuracy.
Advances in understanding Norway spruce natural resistance to needle bladder rust infection: transcriptional and secondary metabolites profiling
Authors: Trujillo-Moya Carlos , Ganthaler Andrea , Stöggl Wolfgang , Arc Erwann , Kranner Ilse , Schueler Silvio , Ertl Reinhard , Espinosa-Ruiz Ana , Martínez-Godoy Maria Ángeles , George Jan-Peter , Mayr Stefan
Published: June 2022

Background

Needle rust caused by the fungus Chrysomyxa rhododendri causes significant growth decline and increased mortality of young Norway spruce trees in subalpine forests. Extremely rare trees with enhanced resistance represent promising candidates for practice-oriented reproduction approaches. They also enable the investigation of tree molecular defence and resistance mechanisms against this fungal disease. Here, we combined RNA-Seq, RT-qPCR and secondary metabolite analyses during a period of 38 days following natural infection to investigate differences in constitutive and infection-induced defence between the resistant genotype PRA-R and three susceptible genotypes.

Results

Gene expression and secondary metabolites significantly differed among genotypes from day 7 on and revealed already known, but also novel candidate genes involved in spruce molecular defence against this pathogen. Several key genes related to (here and previously identified) spruce defence pathways to needle rust were differentially expressed in PRA-R compared to susceptible genotypes, both constitutively (in non-symptomatic needles) and infection-induced (in symptomatic needles). These genes encoded both new and well-known antifungal proteins such as endochitinases and chitinases. Specific genetic characteristics concurred with varying phenolic, terpene, and hormone needle contents in the resistant genotype, among them higher accumulation of several flavonoids (mainly kaempferol and taxifolin), stilbenes, geranyl acetone, α-ionone, abscisic acid and salicylic acid.

Conclusions

Combined transcriptional and metabolic profiling of the Norway spruce defence response to infection by C. rhododendri in adult trees under subalpine conditions confirmed the results previously gained on artificially infected young clones in the greenhouse, both regarding timing and development of infection, and providing new insights into genes and metabolic pathways involved. The comparison of genotypes with different degrees of susceptibility proved that several of the identified key genes are differently regulated in PRA-R, and that the resistant genotype combines a strong constitutive defence with an induced response in infected symptomatic needles following fungal invasion. Genetic and metabolic differences between the resistant and susceptible genotypes indicated a more effective hypersensitive response (HR) in needles of PRA-R that prevents penetration and spread of the rust fungus and leads to a lower proportion of symptomatic needles as well as reduced symptom development on the few affected needles.
Transcriptomic and proteomic analyses of Cucurbita ficifolia Bouché (Cucurbitaceae) response to Fusarium oxysporum f.sp. cucumerium
Authors: Xie Junjun , Ding Yumei , Gao Ting , He Shuilian , Zhao Kai , Yang Xuehu , Zhang Jie , Yang Zhengan
Published: June 2022

Background

Fusarium oxysporum f. sp. cucumerinum (FOC) is the causal agent of cucumber Fusarium wilt, which can cause extensive damages and productivity losses. Cucurbita ficifolia Bouché (Cucurbitaceae) is usually used as rootstock for cucumber because of its excellent resistance to Fusarium wilt. Our previous study found that C.ficifolia has high FOC resistance, the underlying mechanism of which is unclear.

Results

Transcriptome and proteome profiling was performed on the basis of RNA-Seq and isobaric tag for relative and absolute quantitation technology to explore the molecular mechanisms of the response of Cucurbita ficifolia Bouché to Fusarium oxysporum f. sp. cucumerium infection. Comparative analyses revealed that 1850 genes and 356 protein species were differentially regulated at 2d and 4d after FOC inoculation. However, correlation analysis revealed that only 11 and 39 genes were differentially regulated at both the transcriptome and proteome levels after FOC inoculation at 2d and 4d, respectively. After FOC inoculation, plant hormones signal transduction, transcription factors were stimulated, whereas wax biosynthesis and photosynthesis were suppressed. Increased synthesis of oxidative-redox proteins is involved in resistance to FOC.

Conclusions

This study is the first to reveal the response of C. ficifolia leaf to FOC infection at the transcriptome and proteome levels, and to show that FOC infection activates plant hormone signaling and transcription factors while suppressing wax biosynthesis and photosynthesis. The accumulation of oxidative-redox proteins also plays an important role in the resistance of C. ficifolia to FOC. Results provide new information regarding the processes of C. ficifolia leaf resistance to FOC and will contribute to the breeding of cucumber rootstock with FOC resistance.
Comprehensive molecular evaluation of the histone methyltransferase gene family and their important roles in two-line hybrid wheat
Authors: Sun Renwei , Gong Jie , Liu Yongjie , Chen Zhaobo , Zhang Fengting , Gao Jiangang , Cao Junmei , Chen Xianchao , Zhang Shengquan , Zhao Changping , Gao Shiqing
Published: June 2022

Background

Histone methylation usually plays important roles in plant development through post-translational regulation and may provide a new visual field for heterosis. The histone methyltransferase gene family has been identified in various plants, but its members and functions in hybrid wheat related in heterosis is poorly studied.

Results

In this study, 175 histone methyltransferase (HMT) genes were identified in wheat, including 152 histone lysine methyltransferase (HKMT) genes and 23 protein arginine methyltransferase (PRMT) genes. Gene structure analysis, physicochemical properties and subcellular localization predictions of the proteins, exhibited the adequate complexity of this gene family. As an allohexaploid species, the number of the genes (seven HKMTs orthologous groups and four PRMTs orthologous groups) in wheat were about three times than those in diploids and showed certain degrees of conservation, while only a small number of subfamilies such as ASH-like and Su-(var) subfamilies have expanded their members. Transcriptome analysis showed that HMT genes were mainly expressed in the reproductive organs. Expression analysis showed that some TaHMT genes with different trends in various hybrid combinations may be regulated by lncRNAs with similar expression trends. Pearson correlation analysis of the expression of TaHMT genes and two yield traits indicated that four DEGs may participate in the yield heterosis of two-line hybrid wheat. ChIP-qPCR results showed that the histone modifications (H3K4me3, H3K36me3 and H3K9ac) enriched in promoter regions of three TaCCA1 genes which are homologous to Arabidopsis heterosis-related CCA1/LHY genes. The higher expression levels of TaCCA1 in F1 than its parents are positive with these histone modifications. These results showed that histone modifications may play important roles in wheat heterosis.

Conclusions

Our study identified characteristics of the histone methyltransferase gene family and enhances the understanding of the evolution and function of these members in allohexaploid wheat. The causes of heterosis of two-line hybrid wheat were partially explained from the perspective of histone modifications.