bluuebunny/crossref_metadata_2025 huggingface dataset:
Vaccinations and Healthy Ageing: How to Rise to the Challenge Following a Life-Course Vaccination Approach
Authors: Scognamiglio Francesca , Fantini Maria Pia , Reno Chiara , Montalti Marco , Di Valerio Zeno , Soldà Giorgia , Salussolia Aurelia , La Fauci Giusy , Capodici Angelo , Gori Davide
Published: March 2022

In the context of an ageing population, one of the major Public Health goals is to promote healthy ageing. To rise to this challenge, rethinking conventional prevention paradigms and implementing them with vaccination at all stages of life is necessary. Indeed, vaccinations are able to both prevent pathogen specific diseases and all their downstream effects and to increase overall immune system plasticity and resilience. Our aim is to discuss the obstacles and opportunities in pursuing a “life-course vaccination approach” and to highlight the role of vaccines in healthy ageing. In doing so, we address the close connections between immunology and vaccinology advances and introduce the novel concept of immune fitness. Finally, we conclude that even though vaccinology is making giant steps towards tailored vaccination strategies, more studies are needed to investigate this topic.
Patients with Liver Cirrhosis Show High Immunogenicity upon COVID-19 Vaccination but Develop Premature Deterioration of Antibody Titers
Authors: Willuweit Katharina , Frey Alexandra , Passenberg Moritz , Korth Johannes , Saka Nissrin , Anastasiou Olympia E. , Möhlendick Birte , Schütte Andreas , Schmidt Hartmut , Rashidi-Alavijeh Jassin
Published: March 2022

SARS-CoV-2 infection is known to lead to severe morbidity and mortality in patients with liver cirrhosis. For this reason, vaccination of these patients against COVID-19 is widely recommended. However, data regarding immunogenicity in patients with liver cirrhosis is limited and even less is known about the kinetics of antibody response, as well as the optimal timing of booster immunization. We analyzed immunogenicity in 110 patients with liver cirrhosis after receiving two doses of the mRNA-based vaccine BNT162b2 following the standard protocol and compared these results to a control group consisting of 80 healthcare workers. One hundred and six patients with liver cirrhosis (96%) developed antibodies against SARS-CoV-2, compared to 79 (99%) in the control group (p = 0.400). Still, the median SARS-CoV-2 IgG titer was significantly lower in patients with liver cirrhosis compared to the control group (939 vs. 1905 BAU/mL, p = 0.0001). We also analyzed the strength of the antibody response in relation to the time between the second dose and antibody detection. Antibody titers remained relatively stable in the control group while showing a rapid and significant decrease in patients with liver cirrhosis. In conclusion, our data reveals a favorable initial outcome after vaccination with the COVID-19 vaccine BNT162b2 in cirrhotic patients but show a rapid deterioration of the antibody response after time, thereby giving a strong hint towards the importance of early booster immunization for this group of patients.
Design of a Multi-Epitopes Vaccine against Hantaviruses: An Immunoinformatics and Molecular Modelling Approach
Authors: Ismail Saba , Abbasi Sumra Wajid , Yousaf Maha , Ahmad Sajjad , Muhammad Khalid , Waheed Yasir
Published: March 2022

Hantaviruses are negative-sense, enveloped, single-stranded RNA viruses of the family Hantaviridae. In recent years, rodent-borne hantaviruses have emerged as novel zoonotic viruses posing a substantial health issue and socioeconomic burden. In the current research, a reverse vaccinology approach was applied to design a multi-epitope-based vaccine against hantavirus. A set of 340 experimentally reported epitopes were retrieved from Virus Pathogen Database and Analysis Resource (ViPR) and subjected to different analyses such as antigenicity, allergenicity, solubility, IFN gamma, toxicity, and virulent checks. Finally, 10 epitopes which cleared all the filters used were linked with each other through specific GPGPG linkers to construct a multi-antigenic epitope vaccine. The designed vaccine was then joined to three different adjuvants—TLR4-agonist adjuvant, β-defensin, and 50S ribosomal protein L7/L12—using an EAAAK linker to boost up immune-stimulating responses and check the potency of vaccine with each adjuvant. The designed vaccine structures were modelled and subjected to error refinement and disulphide engineering to enhance their stability. To understand the vaccine binding affinity with immune cell receptors, molecular docking was performed between the designed vaccines and TLR4; the docked complex with a low level of global energy was then subjected to molecular dynamics simulations to validate the docking results and dynamic behaviour. The docking binding energy of vaccines with TLR4 is −29.63 kcal/mol (TLR4-agonist), −3.41 kcal/mol (β-defensin), and −11.03 kcal/mol (50S ribosomal protein L7/L12). The systems dynamics revealed all three systems to be highly stable with a root-mean-square deviation (RMSD) value within 3 Å. To test docking predictions and determine dominant interaction energies, binding free energies of vaccine(s)–TLR4 complexes were calculated. The net binding energy of the systems was as follows: TLR4-agonist vaccine with TLR4 (MM–GBSA, −1628.47 kcal/mol and MM–PBSA, −37.75 kcal/mol); 50S ribosomal protein L7/L12 vaccine with TLR4 complex (MM–GBSA, −194.62 kcal/mol and MM–PBSA, −150.67 kcal/mol); β-defensin vaccine with TLR4 complex (MM–GBSA, −9.80 kcal/mol and MM–PBSA, −42.34 kcal/mol). Finally, these findings may aid experimental vaccinologists in developing a very potent hantavirus vaccine.
Xenotransfusion of Blood from Dog to Cat: Should Canine Blood Be Our First Choice for Feline Transfusion in Emergency Situations?
Authors: Deschamps Jack-Yves , Abboud Nour , Roux Françoise A.
Published: March 2022

Despite the ability to determine feline blood types, the transfusion of canine blood to cats is still practiced in some countries. Xenotransfusion is effective—even if its effects only last for a few days—and is not associated with serious adverse effects. It avoids the need for blood typing, and most importantly, it avoids the transmission of intraspecific infectious agents, notably the feline leukemia virus (FeLV). Transfusion with canine blood is easier, quicker and less costly than transfusion with feline blood; it is less disagreeable for the donor. In the light of these arguments, when feline blood collected according to current guidelines is not available, in particular when the donor is not confirmed to be negative for the FeLV provirus, the authors consider it to be judicious to use canine blood for feline transfusion in emergency situations; this practice is preferable to inaction and to the inoculation of an infectious agent. Allotransfusion remains preferable in non-emergency situations as a treatment of chronic compensated anaemiae or if an appropriate donor (negative for FeLV provirus) is available. However, 2–4 days after a xenotransfusion, if a clinical alteration and a significant decrease in haematocrit are observed, a transfusion with cat’s blood confirmed to be negative for FeLV provirus should be performed. Xenotransfusion should never be used twice.
The Robust Study of Deep Learning Recursive Neural Network for Predicting of Turbidity of Water
Authors: Wan Shiuan , Yeh Mei-Ling , Ma Hong-Lin , Chou Tein-Yin
Published: March 2022

Water treatment is an important process, as it improves water quality and makes it better for any end use, whether it be drinking, industrial use, irrigation, water recreation, or any other kind of use. Turbidity is one of the fundamental measurements of the clarity of water in water treatment. Specifically, this component is an optical feature of the amount of light on scatter particles when light is shined on a water sample. It is crucial in water reservoirs to provide clean water, which is difficult to manage and predict. Hence, this study focuses on the use of robust deep learning models to analyze time-series data in order to predict the water quality of turbidity in a reservoir area. Deep learning models may become an alternative solution in predicting water quality because of their accuracy. This study is divided into two parts: (a) the first part uses the optical bands of blue (B), green (G), red (R), and infrared (IR) to build a regression function to monitor turbidity in water, and (b) the second part uses a hybrid model to analyze time-series turbidity data with the recursive neural network (RNN2) model. The selected models’ accuracies are compared based on the accuracy using the input data, forecasting level, and training time. The analysis shows that these models have their strengths and limitations under different analyzed conditions. Generally, RNN2 shows the performance regarding the root-mean-square error (RMSE) evaluation metric. The most significant finding is that the RNN2 model is suitable for the accurate prediction of water quality. The RMSE is used to facilitate a comparison of the accuracy of the sampling data. In the training model, the training data have an RMSE of 20.89, and the testing data have an RMSE of 30.11. The predicted R-squared values in the RNN2 model are 0.993 (training data) and 0.941 (testing data).
PENGARUH RASIO KEUANGAN TERHADAP DIVIDEND PAYOUT RATIO PADA PERUSAHAAN SEKTOR TRADE, SERVICE AND INVESTMENT YANG TERDAFTAR DI BEI
Authors: - Siti Sara , - Erinta Sijabat , - Putri Husyada Fi’lma , - Febti Latreia Missi , - Dwita Sakuntala
Published: March 2022

This study aims to determine the financial ratios represented by the liquidity ratio, activity ratio, solvency ratio, profitability ratio to dividend payout ratio. Data collection techniques using purposive sampling and obtained as many as 21 samples of companies from 132 populations of companies in the trade, service, and investment sectors listed on the Indonesia Stock Exchange (BEI). The analysis technique uses multiple linear regression. Based on the results of the coefficient test, the R square value of 0.141 indicates that the correlation or closeness of the relationship between the liquidity ratio, activity ratio, solvency ratio, profitability ratio and dividend payout ratio is only 14.1%. The Adjusted R Square value of 0.097 indicates that the liquidity ratio, activity ratio, solvency ratio, profitability ratio explains the variable to the dividend payout ratio of 9.7%. The F test shows that the value of Fcount> Ftable (3,235> 2.49) so that simultaneously the quick ratio, Total Asset Turn Over, Debt to Asset Ratio, Return On Equity have an effect on the dividend payout ratio in companies in the trade, service and investment sectors. In the t test results, only the Profitability Ratio (Return On Equity) variable has a positive and significant effect on the dividend payout ratio, which is 0.048.
LITERATURE STUDY REPORT LEVERAGE RATIO ANALYSIS, ACTIVITY RATIO AND PROFITABILITY RATIO TO FINANCIAL DISTRESS CONDITIONS PT INDOFOOD SUKSES MAKMUR TBK
Authors: - Benedictus Putut Bayu Woro
Published: March 2022

This research was conducted with the aim of analyzing the factors that influence the financial distress conditions of PT Indofood Sukses Makmur TBK. This study analyzes the effect of ratios, activity ratios and profitability ratios on stock underpricing. The analytical method used is the literature review method. The results showed that financial distress can be predicted by using financial ratios, namely the leverage ratio, activity ratio, and profitability ratio to prevent company bankruptcy. Furthermore, symptoms of financial disruption from an early age can prevent bankruptcy. For researchers who carry out research in the same field, it is expected to use different variables to calculate the ratio to be able to see from another point of view the effect that occurs, or to add other variables.
IDENTIFICATION OF INDONESIAN ISLAMIC BANKS’ STAKEHOLDERS
Authors: Jahja Adi Susilo , Sri Ramalu Subramaniam A/L , Razimi Mohd. Shahril Ahmad
Published: March 2022

Indonesian Islamic banks should strengthen their legitimacy in the eyes of stakeholders. For this reason, they must satisfy the stakeholders' expectations. Consequently, stakeholder identification is crucial. Previous studies have classified stakeholders of Indonesian Islamic banks into seven types. However, with the increase in the number of Islamic banks and the recent development in the Indonesian banking industry, such classification is needed to be reviewed. This study aims to identify the stakeholders of Indonesian Islamic banks as perceived by these banks. This research method is qualitative descriptive, using secondary data. Data is processed using content analysis. This study advanced knowledge about the types of stakeholders of Indonesian Islamic banks.
PENGARUH ROA, EPS, DER, NPM TERHADAP RETURN SAHAM (STUDI KASUS PADA PERUSAHAAN PERTAMBANGAN BATUBARA YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2017-2019)
Authors: Sonia Sonia Gandhi , - Mellinda
Published: March 2022

This research was conducted on coal mining companies listed on the Indonesia Stock Exchange (IDX). The purpose of this research is to test and analyze the influence of Return On Assets (ROA), Earning PerShare (EPS), Debt to Equity Ratio(DER) and Net Profit Margin (NPM) on Share Return on coal mining companies listed on the Indonesia Stock Exchange in the period 2017-2019 either in a partial or simultaneous manner. The data in this company is secondary data obtained from the Indonesia Stock Exchange (IDX). There is a population in this study obtained from coal mining companies. There are 54 samples of issuers' financial statements using puposive sampling techniques.The results showed that : Return on Assets has a calculated t value of < t table, 0.466 < 1.99254 which means that Return on Assets is partially insignificant and insignificant in the disclosure of a company's Share Return. Earning Per Share has a calculated value of -t > -t table, -0.658 > -1.99254 which means that Earning Per Share is partially insignificant and insignificant in the disclosure of a company's Share Return. Debt to Equity Ratio has a calculated t value of > t table, -3,784 > -1.99254 which means that Debt to Equity Ratio is partially influential and significant in the disclosure of a company's Share Return. Net Profit Margin has a calculated t value of > t table, 4,483 > 1.99254 which means that Net Profit Margin is partially influential and significant in the disclosure of a company's Share Return. Return on Assets, Earning Per Share, Debt to Equity Ratio, Net Profit Margin simultaneously affects Stock Return.
PENGARUH PERGANTIAN AUDITOR, UKURAN PERUSAHAAN, LABA RUGI DAN SOLVABILITAS TERHADAP AUDIT REPORT LAG (SEKTOR INDUSTRI DASAR KIMIA, BARANG KONSUMSI DAN ANEKA INDUSTRI)
Authors: Junri Junri Eliangsor Situmeang , Marbun Wilisra Wilfrida , Yunisa Risa
Published: March 2022

The Basic Industry and Chemicals, Consumer Goods, and Various Industries sectors are companies that are developing very rapidly and well. Audit report lag is the time span for completing an annual financial statement audit, measured by the number of days required to obtain an independent auditor's report on the audit. the company's annual financial statements. The method used in this research is a quantitative approach, the type of this research is descriptive research and the nature of this research is cause and effect research. The data collection method used is to use documentation techniques. The data analysis method used is logistic regression. The population is all companies listed on the Indonesia Stock Exchange in the Basic and Chemical Industry Sector, Consumer Products and Various Industries. Determination of the sample in this study by looking at whether companies in the population report financial statements that have been audited on time or not. The results on the hypothesis show that auditor turnover, firm size, profit and loss and solvency simultaneously have no effect on audit report lag. The conclusion of this study is that simultaneously and partially auditor turnover, firm size, profit and loss and solvency have no significant effect on audit report lag.
KINERJA KEUANGAN PERBANKAN (PERBANDINGAN PADA BANK RAKYAT INDONESIA Tbk DAN BANK CENTRAL ASIA Tbk)
Authors: Lubis Nurhayani
Published: March 2022

This study was conducted to compare the financial performance of BCA and BRI banks. where, these two banks are both in book IV in the bank grouping. The banks in this book group are the banks with the largest capital in Indonesia. The financial ratios used in this study are ROA, LDR, and CAR. the three ratios represent the ratio of profitability, solvency, and liquidity. The data analysis used in this research is independent samples t test. And the results of the study indicate that the three ratios used have significant differences between BRI and BCA banks.
THE EFFECT OF CAPITAL ADEQUACY RATIO (CAR), COST EFFICIENCY RATIO (CER), AND NET INTEREST MARGIN (NIM) ON PROFITABILITY (Study on Sub-Sector Banking Companies Listed on the Indonesia Stock Exchange for the period 2017-2019)
Authors: Pratama Aldi , Lilia Wirda
Published: March 2022

Abstract

The purpose of this study was to analyze the effect of the variable Capital Adequacy Ratio (CAR), Cost Efficiency Ratio (CER), and Net Interest Margin (NIM) on the profitability of sub-sector banking companies listed on the Indonesia Stock Exchange for the period 2017-2019. This type of research uses quantitative methods. This study uses a sample of companies in the sub-sector banking listed on the Indonesia Stock Exchange. Based on the purposive sampling technique, it was obtained a sample of 27 companies by 43 companies of total population. The data used in this study are secondary data in the form of corporate financial reports obtained from the website www.idx.co.id. The results showed that partially and simultaneously the CAR, CER, and NIM variables had a significant effect on profitability.

 

Keywords: Capital Adequacy Ratio (CAR), Cost Efficiency Ratio (CER), Net Interest Margin (NIM), Profitability.
PENGARUH KEPEMIMPINAN, MOTIVASI DAN INSENTIF TERHADAP KINERJA KARYAWAN
Authors: Joannov Joannov , Ernanda Yovie
Published: March 2022

This study aims to examine and analyze the influence of leadership, motivation, and incentives on employee performance at PT. Tamoratama Prakarsa, Medan. A research method is a quantitative approach, this type of research is quantitative descriptive and the nature of this research is explanatory descriptive. The data analysis method is multiple linear regression analysis. The sample of this research is 63 employees. Partially, leadership has a positive and significant effect on employee performance at PT. Tamoratama Prakarsa, Medan. It can be seen from the value of thitung > ttabel or 2,746 > 2,001 and the significant obtained is 0,008 < 0,05. Partially, work motivation has a positive and significant effect on employee performance at PT. Tamoratama Prakarsa, Medan. It can be seen from the value of thitung > ttabel or 2,206 > 2,001 and the significant obtained is 0.000 < 0.05. Partially incentives have a positive effect on employee performance at PT. Tamoratama Prakarsa, Medan. It can be seen from thitung > ttabel or 2,128 > 2,001 and the significant obtained is 0,037 < 0,05. Simultaneously leadership, work motivation, and incentives have a positive and significant effect on employee performance at PT. Tamoratama Prakarsa, Medan seen from the value of Fhitung (11.402) > Ftabel (2.76) and a significance probability of 0.000 < 0.05.
PENGARUH INTELLECTUAL CAPITAL TERHADAP PRODUKTIVITAS PERBANKAN DI INDONESIA
Authors: Warga Dalam Winanda , Nurfaizah Siti
Published: March 2022

This study examines whether banking productivity as proxies by ATO and EP is not influenced by intellectual capital. Purposive sampling is used in the sampling technique of the banks listed on the Indonesia Stock Exchange for the 2015-2019 period which is the archival data in this study. The total sample is 105 data obtained from 21 companies for 5 years. This study uses panel data regression analysis. The results showed that intellectual capital had an effect on ATO and EP. VAHU has no effect on ATO and EP, VACA has no effect on ATO and EP, STVA has no effect on ATO and EP. This research is limited to the banking sector listed on the Indonesia Stock Exchange.
İnsan Endometriyum Epitel Hücrelerinde Farklı Kontrollü Ovaryan Hipersitümulasyonu Protokollerinin Eksozom Belirteci CD63 Üzerine Etkisi
Authors: ÖZGÜL ÖNAL Melike , UYAR Yıldız , ÖZTÜRK Ulviye Cansu , VATANSEVER Seda
Published: March 2022

Giriş ve Amaç: Eksozomlar; protein, mRNA ve miRNA’ları taşıyan ve hedefledikleri hücrelerde/dokularda fonksiyonel değişikliklere neden olan kargo sistemleridir. CD63, eksozomların tanımlanması ve izolasyonu için anahtar proteindir. Kontrollü ovaryan hiperstimülasyonu (KOH) protokollerinde kullanılan farmakolojik ajanların oosit sayısını ve kalitesini arttırarak ovulasyonu indüklediği bilinmekte fakat endometriyum hücreleri üzerindeki etkileri tam olarak bilinmemektedir. Bu çalışmada; CRL-1671 insan endometriyum hücrelerinde, KOH protokollerinde kullanılan ilaçlarının eksozom belirteci olan CD63 üzerine etkilerinin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntemler: CRL-1671 hücreleri; kontrol grubu, büyüme hormonu (GH) uygulanan grup, Gonadotropin (GnTR) uygulanan grup, GH+GnTR uygulanan grup, Letrozol (L)+GnTR uygulanan grup ve üçlü kombine (L+GnTR+GH) grubu olacak şekilde 8 gün boyunca kültüre edildi. İnkübasyon sonunda hücrelerde CD63 dağılımı indirekt-immunositokimya tekniği ile incelendi.

Bulgular: CD63 immunoreaktivitesinin kontrol grubunda orta (++), GnTR ve L+GnTR gruplarında kuvvetli (+++) ve diğer ilaç uygulanan gruplarda orta (++) şiddette olduğu gözlendi. H-score değerleri sırası ile 298 ± 6,71; 300 ± 5; 397 ± 12,55; 303 ± 2,74; 302 ± 5,70 ve 391 ± 4,18 olarak hesaplandı. Kontrol grubu ile karşılaştırıldığında GnTR ve L+GnTR uygulanan gruplarda istatistiksel anlamlı farklılık belirlendi (p
Manisa Yöresinde Beta-Talasemi Mutasyon Dağılımı
Authors: KADER Şebnem , GULEN Huseyin , TANELİ Fatma
Published: March 2022

Giriş ve Amaç: Beta (β)-talasemi, Türkiye’deki en yaygın genetik bozukluklardan biridir. Bu çalışmanın amacı Manisa ili ve çevresindeki β-talasemi mutasyonlarının tipini ve dağılımını tespit etmek, Manisa'nın Türkiye β-talasemi mutasyon haritasındaki yerini belirlemektir.

Gereç ve Yöntemler: Bu çalışma; Etik Kurul onayı alındıktan sonra Celal Bayar Üniversitesi Üniversitesi Tıp Fakültesi, Çocuk Hematoloji Bilim Dalı’ nda prospektif olarak gerçekleştirildi. Çalışmaya, β-talasemi major ve β-talasemi taşıyıcılığı tanısıyla takip edilen 85 hasta alındı. β-talasemi taşıyıcılarında çalışmaya dahil edilme kriteri olarak HbA2 düzeyinin % 3.5’in üzerinde olması dikkate alındı. Beta Globin Strip Assay yöntemi ile beta globin geninde sıklıkla görülen ve Akdeniz ülkelerine özgü 22 mutasyon tarandı.

Bulgular: Çalışmaya dahil edilen 85 hastanın 15’inde, taranan 22 mutasyondan hiç birinde pozitiflik saptanmadı. Kalan 70 hastanın 2 tanesinin birleşik heterozigot formunda (%2.8), 1 hastanın homozigot formunda (1.4), 67 hastanın da heterozigot formunda (%95.8) mutant allel taşıdığı tespit edildi. En yaygın görülen β-talasemi mutasyonu, Türkiye genelinde olduğu gibi IVS1-110 (% 35.3) olarak bulundu. Bunu sırasıyla IVS2-1 (%14.1), codon 39 (%8.2), IVS2-745 (%7.1), IVS1-6 (%5.9), IVS1-1 (%3.5), codon 5 (%2.4), codon 8 (%3.5), codon 44 (%2.4), -87 (%1.2), codon 36/37 (%1.2) mutasyonları takip etti.

-30, HbC, HbS, codon 6, codon 8/9, codon 22, codon 30, IVS1-2, IVS1-5, IVS1-116, IVS1-25, codon 44 mutasyonları hiçbir hastamızda tespit edilmedi.

Sonuç: Çalışmamızda beta globin strip assay testinin sensivitesi % 82.3 oranında bulundu. Beta-Talasemi mutasyonları açısından Türkiye’deki genel ortalamanın Manisa’da da değişmediği, IVS1-110 mutasyon tipinin Manisa’da da en sık mutasyon olduğu bulundu. Manisa ilinde talasemi taşıyıcılığının % 4.5 gibi yüksek bir oranda bulunmasının yanı sıra en çok göç alan iller arasında yer alan ilimizde akraba evliliğinin fazla görülmesinden dolayı prenatal tanı merkezlerinin arttırılması ve bir halk sağlığı sorunu olan bu konu üzerinde aktif olarak çalışılması gerektiğini düşünmekteyiz.
Platelet Variability İndex’in Serebrovasküler Olaylardaki Tanısal Değerinin Değerlendirilmesi Ve Önemi
Authors: ŞİMŞEK Bora , SAĞLAM GÜRMEN Ekim
Published: March 2022

Giriş ve Amaç: Akut inmeye bağlı mortalite ve morbidite oranları yüksek olduğundan bu hastaların erken prognoz öngörüsünü yapmak önemlidir. Acil serviste iskemik ya da hemorajik inme tanısı alan hastaların Ortalama trombosit hacmi (MPV), Platelet (PLT) ve MPV/PLT değerleri ile hastaların demografik özellikleri, triaj kodu, sonlanımı, hastaların vital parametreleri ve Glaskow Koma Skalası (GKS) arasındaki ilişki değerlendirilmeye çalışılmıştır.

Gereç ve Yöntemler: Bu çalışma 3. Basamak Üniversite Hastanesi Acil servisine başvuran 18 yaş üstü, yapılan tetkikler neticesinde iskemik veya hemorajik inme tanısı alan 200 hasta üzerinde retrospektif olarak yapılmıştır.

Bulgular: Çalışmamıza 116 (%58)’sı erkek olmak üzere toplam 200 hasta dahil edilmiştir. Hastaların yaş ortalaması 68 yıl olarak tespit edilmiştir. Hastaların 178 (%89)’inin iskemik, 22 (%11)’sinin hemorajik inme tanısı aldığı görüldü. Hastaların yaşı ve MPV/PLT oranları arasında korelasyon bulunmuştur (p
Oosit Matürasyonuna Yeni Bir Bakış: N6-metiladenosin Metilasyonu
Authors: AKOĞULLARI Damla , VATANSEVER Hafize Seda
Published: March 2022

Oosit matürasyonu prenatal dönemden puberteye kadar süren birçok proteinin karşılıklı etkileşimiyle kontrol edilen bir süreçtir. Matür oositin kalitesi ileri fertilizasyon ve implantasyon başarısını doğrudan etkileyerek kaliteli embriyo oluşumuna temel oluşturmaktadır. Oositin matürasyon süreci in vivo ve in vitro ortamlarda araştırma konularından biri olup günümüzde hem sürecin anlaşılması hem de kültür ortamındaki koşulların belirlenmesine yönelik çalışmalar devam etmektedir. N6-metiladenosin (m6A) en yaygın RNA modifikasyonlarından biridir. m6A metilasyonunda metil gruplarının eklenmesinden sorumlu metiltransferazlar (yazıcılar), metil gruplarının kaldırılmasından sorumlu dimetilazlar (siliciler) ve metil grubunu bağlayıcı proteinler (okuyucular) olmak üzere üç grup protein görev almaktadır. Son yıllarda kanser, metabolik hastalıklar gibi süreçlerde önemli rolleri olduğu kanıtlanan m6A metilasyonunun oogenez ve spermatogenez süreçlerindeki yeri ve önemi de yapılan çalışmalarla ortaya çıkarılmaktadır. Bu derlemede oosit matürasyonu ve m6A metilasyonunu tanımlanması, aralarındaki ilişkinin araştırılması ve sonuçta oosit matürasyonuna m6A metilasyonu ve/veya proteinlerinin direkt/indirekt etkilerinin tartışılması amaçlanmıştır.
Pre-menopozal Dönemdeki Kadınlarda Dairesel Antrenman Eğitiminin Vücut Kompozisyonuna Etkisi
Authors: BASKAN Özden , BASKAN Emre , YAĞCI Nesrin
Published: March 2022

Giriş ve Amaç: Çalışmamız premenopozal dönemdeki kadınlarda dairesel antrenman eğitiminin vücut kompozisyonuna etkisini araştırmak amacıyla planlanmıştır.

Gereç ve Yöntemler: Bu çalışmaya Denizli’de yaşayan premenopozal dönemde olan 35-53 yaşları arasında 49 kadın (ortalama yaş: 39,32±4,16 yıl.) dâhil edilmiştir. Kadınlara 8 hafta dairesel antrenman eğitimi (haftada 5 gün, günde 1 kez 30 dakika) bir Fizyoterapist tarafından verilmiştir. Bu eğitim kişilerin kendi kapasite ve hızlarına uygun olarak 9 adet izokinetik istasyon çalışması ve aerobik egzersizlerden oluşmaktadır. Çalışma, 30 saniye yüklenme, 30 saniye aerobik egzersizden oluşmuştur. Egzersiz istasyonları abdominal, sırt, kalça, diz, omuz ve dirsek çalışmalarını içermektedir. Eğitimden önce ve 8 hafta sonra vücut kompozisyonuna ait ölçümler (göğüs, bel, kalça, üst ekstremite ve alt ekstremite çevre ölçümleri ve baskül ile vücut ağırlığı, yağ ve su miktarı) alınmıştır.

Nutrisyonel Risk Taraması Ölçeği (Nutritional Risk Screening) kullanılarak toplanmıştır.

Bulgular: 8 haftalık eğitim sonunda çalışmaya alınan kadınların vücut ağırlığı önemli düzeyde azalmıştır (p=0,0001). Vücut kompozisyonuna ait ölçümler karşılaştırıldığında su ve kas miktarı (p>0,05) hariç tüm ölçümlerde eğitim sonunda önemli düzeyde azalma meydana gelmiştir (p=0,0001).

Sonuç: Çalışmamızın sonuçları göstermiştir ki premenopozal dönemdeki kadınlarda dairesel antrenman eğitimi vücut kompozisyonuna olumlu yönde etki etmektedir.
Sitokalasin B Tedavisi, Nrf2 Sinyal Yoluyla U87 Glioblastoma Hücrelerinde Anti-Proliferatif Etkiler Gösterdi
Authors: HACIOĞLU Ceyhan , KAR Fatih
Published: March 2022

Giriş ve Amaç: Glioblastoma kötü prognozlu agrasif beyin tümörlerinden biridir ve glioblastoma için mevcut tedavi yöntemleri oldukça sınırlıdır. Sitokalasin B'nin (CB) kanser hücre hatları üzerinde inhibitör etki göstermektedir, ancak antikanser etkileri henüz tam olarak anlaşılamamıştır. Bu çalışmada, CB'nin U87 insan glioblastoma hücrelerinde nükleer faktör eritroid 2 ile ilişkili faktör (Nrf2) sinyal yolağı üzerinden oksidatif, antioksidan ve DNA hasar mekanizmaları üzerindeki etkisini araştırmayı hedefledik.

Gereç ve Yöntemler: İlk olarak, CB'nin U87 hücrelerindeki sitotoksik konsantrasyonlarını MTT analizi ile belirledik. Ardından, CB'nin Nrf2 seviyeleri üzerindeki etkisini ve bununla bağlantılı olarak total oksidan kapasite (TOS), malondialdehit (MDA), süperoksit dismutaz (SOD) ve glutatyon peroksidaz (GPx) seviyeleri ölçüldü. Son olarak, CB ile tedavi edilen U87 hücrelerindeki DNA hasarını tespit edebilmek için 8-hidroksi-2'-deoksiguanozin (8-OHdG) seviyeleri ölçüldü.

Bulgular: MTT analizine göre, CB'nin U87 hücrelerinde canlılığı konsantrasyona bağımlı bir şekilde azalttığını belirledik ve IC50 konsantrasyonunu 62,8 μM olarak tespit ettik. Ardından, 5,1, 33,6 ve 62,8 μM CB ile tedavi edilen U87 hücrelerinde TOS, MDA ve 8-OHdG seviyeleri konsantrasyon bağımlı bir şekilde artmıştır (p
High-Flux 100 kHz Attosecond Pulse Source Driven by a High-Average Power Annular Laser Beam
Authors: Ye Peng , Gulyás Oldal Lénárd , Csizmadia Tamás , Filus Zoltán , Grósz Tímea , Jójárt Péter , Seres Imre , Bengery Zsolt , Gilicze Barnabás , Kahaly Subhendu , Varjú Katalin , Major Balázs
Published: March 2022

High-repetition rate attosecond pulse sources are indispensable tools for time-resolved studies of electron dynamics, such as coincidence spectroscopy and experiments with high demands on statistics or signal-to-noise ratio, especially in the case of solid and big molecule samples in chemistry and biology. Although with the high-repetition rate lasers, such attosecond pulses in a pump-probe configuration are possible to achieve, until now, only a few such light sources have been demonstrated. Here, by shaping the driving laser to an annular beam, a 100 kHz attosecond pulse train (APT) is reported with the highest energy so far (51 pJ/shot) on target (269 pJ at generation) among the high-repetition rate systems (>10 kHz) in which the attosecond pulses were temporally characterized. The on-target pulse energy is maximized by reducing the losses from the reflections and filtering of the high harmonics, and an unprecedented 19% transmission rate from the generation point to the target position is achieved. At the same time, the probe beam is also annular and low loss of this beam is reached by using another holey mirror to combine with the APT. The advantages of using an annular beam to generate attosecond pulses with a high-average power laser are demonstrated experimentally and theoretically. The effect of nonlinear propagation in the generation medium on the annular-beam generation concept is also analyzed in detail.
Construction of Lyapunov Functions for the Stability of Fifth Order Nonlinear Ordinary Differential Equations
Authors: Aye Patrick O. , Jayeola D. , Oyewola David O.
Published: March 2022

This study employed Lyapunov function method to examine the stability of nonlinear ordinary differential equations. Using direct Lyapunov method, we constructed Lyapunov function to investigate the stability of fifth order nonlinear ordinary differential equations. V(x), a quadratic form and positive definite and U(x) which is also positive definite was chosen such that the derivative of V(x) with respect to time would be equal to the negative value of U(x). We adopted the pre-multiplication of the given equation by x..... and obtained a Lyapunov function which established local and global stability of a fifth order differential equation.
The Multifaceted Problems of the Diaspora as Revealed in the Novel Kadavucheetu
Authors: G Anantharajan
Published: March 2022

In primitive society, people migrated from one place to another, either individually or in ethnic groups, due to herding, hunting, and natural disasters. Subsequently, while immigration continued in the Sangam period, the kappiyam period, and the Bhakthi period, the background of migration over time began to intensify due to poverty, ethnic strife, and political crises. From the novel 'Kadavucheetu' by the expatriate Tamil novelist V. Jeevakumaran that contemporary emigration is very painful and has caused many losses in life. The study identifies the biological problems faced by Tamils who fled their homeland to Sri Lanka, lost their ties, lost their possessions and fled to Denmark as refugees, and their multiple losses, as shown in the passport novel.
Tamizh Maathu Ko Swappaneshwari Ambal
Authors: P Vijayakumar
Published: March 2022

Tamil Maadhu Swapneswari Ambal was a pioneer of feminism who had been doing various works for the advancement of women in the early twentieth century. He was the editor of Tamil Maadhu (1905). Thereby striving for the advancement of women. Born in 1846, he was heavily involved in the work of Iyothee Thass Pandit, a pioneer of the Buddhist renaissance. Pandit Rayapettai also attended the Sunday evening sermon at the Buddhist Association and delivered a sermon. He was presented with a section in the Tamil magazine 'Pengal Patthi' which was reserved for women. He wrote a series of short articles on a number of topics. After the demise of the Pandit, he converted to Buddhism and continued to practice Buddhism. Thus, he is identified by the Buddhists as 'Maha Upasaki'. She has run many organizations for the advancement of women, including the 'Women's Education Development Association' and the 'Widow Care Monastery' for widows. He put forward the idea that women who have lost their husbands should come forward to remarry without being paralyzed at home. He was keen to realize that women are enslaved by ignorance and to become rational thinkers. He protested against child marriages taking place at that time. He said that women in family life should not be dependent on others but should be meant to help others. Thus, she has been a voice for the advancement of women on many levels. Swapnaneswari Ambal. Today's Tamil world should know and praise her extensive social work and women's liberation work
Tamilar Valviyalil Pullinangal
Authors: M Jayalakshmi
Published: March 2022

The Sangam Tamil people lived in the worship and respect of nature and worshipped as Lord. These blend in with the natural environment. They have preserved and lived a harmonious life. This information can be gleaned from the verses, hymns, and meat objects found in the songs sung by the Sangam poets in the Ettuthogai Noolgal. Although the name bird is given to all flying creatures in Sangam Texts, it is often said to belong to the point of laying eggs and hatching. The Dragonfly, beetle, etc. are also given the name of the flying bird. That is the case with minorities. The Sangam texts show that the name ' Pull' is derived from what is now considered a bird. The purpose of this article is to explore how birds and native life came to be found in the wild. Today many bird species are extinct. This article aim of creating a future idea of ​​conserving bird species.
Psychological attitudes of a friend in the Agananooru
Authors: A Revathi , K Devi Booma
Published: March 2022

The Sangam literature lists a hundred of chronological verses in the order in which the hero presents the life of internal morals. and it also represents verses of ‘Agananooru’. The first person to appear in Sangam literature is the friend. It we look at the psychological attitude of the friend in this book, the romance and chastity of the hero and heroine to the nerd level. In this essay, she can ln seen as a literary work that puts everything on the thematic end in the hands of romance and chastity who changes or solves the veil that calms the feelings of inner demons without living for her self.
Velliveethiyar Songs Perception
Authors: S Rishvana Parveen
Published: March 2022

Female poets have sung fewer songs than any other literary genre. There is a difference between the central theme in masculine songs and the central theme in feminist songs. Poems composed by poets have a deep expression and environment. Thus, her sentiments are expressed in the songs of Sangam literary feminist Vellividiyar. Tolkappiah says that feminine lust should be symbolized. But Vellividiyar's introspection is a way of expressing the woman's lust and indivisibility. The purpose of this research paper is to express the expression of lust (love), the dilemma of power, the condemnation of adultery and consensus in his songs.
Choristoma of Internal Auditory Canal: Literature Review
Authors: Диаб Х.М. , Дайхес Н.А. , Сайдулаев В.А. , Пащинина О.А. , Юнусов А.С. , Умаров П.У. , Терехина Л.И.
Published: March 2022

Хористомы внутреннего слухового прохода являются чрезвычайно редкими опухолями. Из-за их редкости и отсутствия характерной клинической и рентгенологической картины их обычно ошибочно диагностируют как вестибулярные шванномы. Единственным методом дифференциальной диагностики хористомы от шванномы является патогистологическое исследование удаленной опухоли, при котором обнаруживают нервные волокна, гладкую мышечную ткань и небольшое количество жировой ткани. Опухоль вовлекает в патологический процесс кохлеовестибулярный и лицевой нервы и обычно интимно спаяна с ними, что представляет серьезную проблему для хирурга. Именно поэтому нет единого мнения относительно тактики лечения данной категории пациентов.

Choristomas of the internal auditory canal are extremely rare tumors. Due to their rarity and lack of specific clinical and radiological signs, it is usually misdiagnosed as vestibular schwannomas. The only method of differential diagnosis of choristoma and schwannoma is pathohistological examination of the resected tumor. Pathohistological examination of the tumor shows nerve fibers, smooth muscle tissue and a small amount of adipose tissue. The tumor involves the cochleovestibular and facial nerves in pathological process and is usually intimately soldered to them, which is a serious problem for the surgeon. That is why there is no consensus on the tactics of treatment of this category of patients.
Best Practice of Prevention of Covid-19 Transmission Through Small Island Region Quarantine
Authors: Zuardin Zuardin , Azhar Al , Satriani Wa Ode Heni
Published: March 2022

This study aimed to analyze the quarantine strategy of Kadatua Island to prevent the transmission of Covid-19. The Data was obtained through direct observation and in-depth interviews with the Covid-19 countermeasure officer in the region. The research used an explanatory sequential mix-method, where the researcher first conducts quantitative research, analyzes the results, and arranges them, to explain in more detail with qualitative research. We found that Kadatua Island is a small island and separated from the mainland of South Buton district has the advantage that it is relatively easy to control the mobility of newly arrived residents from outside the area. Local governments and indigenous people work together in a regional quarantine effort with a coordinated supervision system. When the community wants to enter Kadatua Island, they will be directed to do a regional quarantine, empty houses will be prepared for 14-21 days and will be closely monitored by village officials. During the home quarantine, food for people undergoing quarantine was provided by their respective families and some were supplied from the village. In addition, the efforts of indigenous peoples are also called 'poago' by forbidding communities from doing activities outside and making sounds. All these efforts are considered effective, especially in controlling the transmission of Covid-19 on Kadatua Island. The effectiveness is supported by several geographical locations, local government policies that are health-oriented, and supports from citizens and indigenous peoples. Local governments need to make similar strategies on a larger scale for other island regions.
The Symbolic Meaning of Wedding Offerings in Buru Island
Authors: Iye Risman
Published: March 2022

The meaning of a marriage is the union between the two brides, namely a man and a woman. This research examines the symbolic meaning of the groom's surrender to the bride. The approach used in this study is a semantic approach. The semantic approach is an approach to see the form of speech and interpret the form of the speech or the meaning of symbols. In determining the source of data for research, it is based on the ability and skill of the researcher in trying to uncover a subjective event and determine the informant in accordance with the terms and conditions so that the data needed by the researcher is truly in accordance with nature or concrete facts. Data collection techniques carried out in this study were interviews, recording, notes, and documentation. Data analysis is a process of arranging data sequences, organizing them into patterns, categories, and basic units of description. The data that has been obtained through the recordings, then analyzed using descriptive methods, namely the depiction of the facts found as they are. The results of the study show that there are seven forms of offerings given by the groom, namely a. seserahan banana, b. seserahan betel leaf, c. seserahan ring, d. women's clothing e. traditional food and fruits, f. household furniture. g. surrender of money. Then from the meaning of the surrender, the two existing cultural values are, the social values contained in the handover ceremony at the Buru Island marriage and cultural values.
Analisis Faktor Risiko Gangguan Muskuloskeletal Pada Karyawan Kependidikan STIKES Suaka Insan
Authors: Wicaksono Utomo , Leluni Kristina Novita , Kusumawati Ninuk , Sadu Bernadus , Prayogo Dadan , Issohone Michaela Putri Kasinem
Published: March 2022

Gangguan muskuloskeletal dapat disebabkan karena aktivitas yang dilakukan secara rutin dalam penggunaan komputer oleh para pekerja di Perguruan Tinggi. Tujuan penelitian ini untuk menganalisis hubungan jenis kelamin, usia, IMT, kebiasaan olahraga, masa kerja, waktu kerja, dan penggunaan komputer terhadap gangguan muskuloskeletal. Metode penelitian ini menggunakan desain crossectional yang dilakukan terhadap dosen dan tenaga pendidik sebanyak 34 orang yang telah memenuhi minimal sample dengan teknik pengambilan sampel accidental sampling. Instrumen untuk mendapatkan data gangguan muskuloskeletal menggunakan Nordic Body Map (NBM). Data dianalisis menggunakan uji Chi-Square dengan tingkat kemaknaan 5% (α=0.05). Adapun hasil dari penelitian ini menunjukkan bahwa faktor-faktor risiko yang dianalisisis yaitu  jenis kelamin p=0,69, usia p=0,18, IMT p=0,53, masa kerja p=0,32, waktu kerja p=0,32, penggunaan komputer p=0,43 yang artinya variabel-variabel tersebut tidak bermakna terhadap gangguan muskuloskeletal dan terdapat satu faktor risiko yang bermakna terhadap gangguan muskuloskeletal yaitu kebiasaan olahraga p=0,02. Hasil dari penelitian ini adalah satu-satunya faktor risiko yang berpengaruh terhadap gangguan muskuloskeletal ialah kebiasaan olahraga.
Pengaruh Kepemimpinan dan Supervisi Akademik Kepala Sekolah Terhadap Disiplin Kerja Guru di SMP Negeri 3 Harian
Authors: Nadeak Mujur
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan dan supervisi akademik kepala sekolah terhadap disiplin kerja guru di SMP Negeri 3 Harian Kab. Samosir Sumatera Utara. Penelitian kuantitatif ini menggunakan total sampling dengan instrumen pengumpulan data berupa kuisioner. Hasil penelitian memberikan kesimpulan bahwa secara terpisah kepemimpinan kepala sekolah tidak berpengaruh signifikan terhadap disiplin kerja guru namun kegiatan supervisi akademik yang dilakukan kepala sekolah memberikan pengaruh signifikan terhadap disiplin kerja guru. Sementara jika secara simultan atau secara bersamaan, terdapat pengaruh signifikan yang diberikan oleh faktor kepemimpinan dan supervisi akademik kepala sekolah terhadap disiplin kerja guru.
OPTIMASI PUBLIC SWITCHED TELEPHONE NETWORK ( PSTN ) MENGGUNAKAN ALGORITMA GREEDY DAN ALGORITMA STAR DENGAN PT. TELKOM KUPANG SEBAGAI MODEL
Authors: Maggang Amin A. , Manafe Beby H. A.
Published: March 2022

Kualitas dari sebuah jaringan telepon dapat dilihat dari kemampuan jaringan untuk melewatkan semua aliran trafik. Jaringan dikatakan memiliki kualitas yang baik atau optimum, apabila jaringan mampu untuk melewatkan semua trafik sesuai dengan Grade of Service (GoS) yang ditawarkan. Penelitian ini bertujuan untuk mendapatkan model jaringan telepon dengan aliran trafik yang optimum sehingga dapat ditentukan link untuk menghubungkan suatu sentral dengan sentral lainnya dengan pemakaian kapasitas sirkit yang optimum. Pengoptimasian aliran trafik ini dilakukan dengan menggunakan algoritma greedy dan algoritma star. Penelitian ini menggunakan 9 sentral/node. Dimana intensitas trafik yang digunakan adalah intensitas trafik yang paling maksimum dan minimum diantara kesembilan sentral tersebut. Yang nilainya masing-masing adalah 176.7 erlang dan 0 erlang. Nilai intensitas trafik ini, digunakan untuk membangkitkan trafik secara acak agar mendapatkan nilai intensitas trafik rata-rata pada setiap sentral yang kemudian direpresentasikan dalam matriks T dan matriks U. Nilai kedua matriks ini yang dipakai oleh algoritma Greedy dan algoritma Star untuk memodelkan jaringan. Dengan diperolehnya model jaringan ini kemudian dicari matriks D untuk perhitungan Z(T). Dari hasil simulasi yang diperoleh dari kedua algortima, menunjukan bahwa model jaringan yang dihasilkan oleh algortima Star adalah model jaringan yang optimum karena dari 30 kali percobaan model jaringan algortima Star memiliki nilai Z(T) lebih kecil dibandingkan dengan nilai Z(T) algoritma Greedy.
ANALISA PERBANDINGAN BEBERAPA METODE DETEKSI TEPI PADA CITRA RONTGEN PENYAKIT PARU PARU
Authors: Rahmadewi Reni
Published: March 2022

Pengolahan citra sekarang ini sudah sangat pesat dalam berbagai bidang kehidupan, seperti bidang kesehatan yaitu dengan melakukan metode deteksi tepi pada citra rontgen paru-paru. Pada penelitian ini citra rontgen paru-paru yang diolah ada 6 jenis penyakit paru yaitu penyakit Tuberkulosis, Pleuritis, Pneumonia, Emfisema, Bronkitis dan Kanker Paru. Setiap citra mempunyai identifikasi/ informasi tertentu yang terletak pada gambar yang diperlihatkannya. Informasi tersebut sangat diperlukan bagi orang yang meneliti dibidang citra itu sendiri.Simulasi ini dirancang untuk mendapatkan hasil berupa citra digital yang memiliki kualitas yang lebih baik dalam mempertajam pola citra hasil rontgen paru-paru. Pengolahan citra meliputi tahapan pembersihan noise/ derau dengan high-pass filtering. Kemudian segmentasi citra yaitu operasi pengambangan (thresholding), selanjutnya dilakukan deteksi tepi. Penulisan ini membahas tentang perbandingan hasil deteksi tepi dengan 3 metode operator yaitu operator Prewitt, operator Sobel, dan operator Canny untuk mengidentifikasi penyakit dari pada citra itu sendiri. Hasil pengujian yang dilakukan pada 18 citra rontgen penyakit paru didapatkan hasil deteksi tepi yang lebih baik pada operator Sobel yaitu 100% dan operator Prewit 50% sedangkan operator Canny menghasilkan deteksi tepi kurang bagus.