bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial Distribution and Determinant Factor of Women's Unemployment Status in Ethiopia
Authors: Hirbo Hirbo Geremew , Kuse Kenenisa Abdisa , Asnakew Alemnesh Mulugeta , Wudu Tadele Kasahun
Published: December 2023

Background: Those who are capable of working but do not have a job are said to be unemployed and are looking for compensation or profit. One of the biggest issues facing both developed and developing nations in the modern era is unemployment. Private and societal issues including prostitution, alcoholism, poverty, and an increase in crimes are all caused by unemployment. This study's primary goal was to characterize the geographic disparities in women's unemployment in Ethiopia. Techniques: The EDHS 2016 provided the dataset used in this investigation. Basic social and demographic information was included in the data. We used spatial analysis to find the geographical variation in our data.
Findings: Of the 15683 women who participated in the study, 10011 (63.8%) are unemployed, and 5672 (36.2%) are employed in Ethiopia. in line with EDHS data from 2016. The Global Moran's I test results show that Ethiopian women's unemployment rates were either clustered or not random. Nearly the whole region of Afar and Somalia, southwest Tigray, north and west Oromia, and eastern and southern Amhara were identified as high-risk areas for women's unemployment status. Conversely, low-risk areas included Addis Abeba, eastern and central Oromia, Gambela, Dire Dawa and Hariri, nearly all Benshangul-bearing areas, and the eastern SNNPR.
Conclusion: This study shows the regional cluster-level spatial distribution of women's unemployment status in Ethiopia. High outlier clusters were found to be more prevalent than low outlier clusters, according to the cluster and outlier analysis. The eastern regions of Tigray and Gambela, the central portion of Oromia, and the western portion of Benshangul Gumuz were the locations of these high outliers. However, low outliers were primarily discovered in Northern and Central Somalia, Eastern Afar, Eastern Amhara, Eastern and Northern part of Oromia, and Western Tigray.
Reprogramming of DNA methylation and changes of gene expression in grafted Hevea bralisiensis
Authors: Li Hui-Liang
Published: December 2023

Rubber tree (Hevea bralisiensis) is reproduced by bud grafting for commercial planting, but significant intraclonal variations exist in bud-grafted clones. DNA methylation changes related to grafting may be partly responsible for intraclonal variations. In the current study, whole genome DNA methylation profiles of grafted rubber tree plants (GP) and its donor plants (DP) were evaluated by whole genome bisulfite sequencing. Data showed that DNA methylation were down-regulated and DNA methylations in CG, CHG and CHH sequences were reprogrammed in GP, suggesting graft induced reprogramming of DNA methylation. 5939 differentially methylated genes (DMGs) were identified by comparing fractional methylation levels between GP and DP. Transcriptional analyse revealed that there were 9798 differentially expression genes (DEGs) in the DP and GP comparison. 1698 overlapping genes between DEGs and DMGs were identified. These overlapping genes were markedly enriched in the metabolic pathway and biosynthesis of secondary metabolites by KEGG pathway analysis. Global DNA methylation and transcriptional analyses revealed that reprogramming of DNA methylation is correlated with gene expression in grafted rubber tree. The study provides a whole genome methylome of rubber tree and an insight on the molecular mechanisms underlying the intraclonal variations existing in commercial planting grafted rubber trees.
Stochastic Multivariable Extremum Seeking Control Considering Input and Output Delays
Authors: Silva Paulo Cesar S. , Pellanda Paulo Cesar , Oliveira Tiago Roux
Published: December 2023

This paper introduces a design and analysis framework for a multivariable gradient-based stochastic extremum-seeking control system that considers delays. The study addresses multi-input systems with time delays in both input and output channels. The introduced new predictor feedback mechanism utilizes stochastic sinusoidal perturbation-based estimates of the Hessian's matrix in order to compensate the delay effects in the real-time optimizer. The incorporation of this feedback into the closed-loop system ensures exponential stability for the average dynamics and convergence to a small neighborhood around the unknown extremum point. The derived results are rigorously established through the application of backstepping transformation and stochastic averaging techniques in infinite dimensions. The effectiveness of the proposed predictor-based stochastic extremum seeking approach for delay compensation is illustrated through a numerical example.
EM-DAT: the Emergency Events Database
Authors: Delforge Damien , Wathelet Valentin , Below Regina , Sofia Cinzia Lanfredi , Tonnelier Margo , Loenhout Joris van , Speybroeck Niko
Published: December 2023

The Emergency Events Database (EM-DAT) compiles global disaster data resulting from both technological and natural hazards. It details the human and economic impacts from 1900 to present, with systematic recording since 1988. Serving the humanitarian, disaster risk reduction, and academic sectors, EM-DAT's transition to open access and increasing climate change concerns have expanded its reach and visibility. The dataset, freely available for non-commercial use, is downloadable as an Excel file. It is categorized by hazard type and standardized by individual disaster events for each country. With over 26,000 unique entries, the database is populated through the monitoring of textual documents and their manual processing. The data collection and validation processes involve systematic daily checks from predefined sources, searches for additional sources, and periodic thematic updates. The evolution of EM-DAT's data content mirrors societal and technological advancements in disaster reporting. Besides these progresses, known inconsistencies and biases in the data quality have been reported. The article acknowledges these issues, highlighting their potential implications for research and decision-making.
Student Value Co-creation Behaviour in The Higher Education Service Ecosystem: An Empirical Exploration
Authors: Zamora-Ramos Moises Ruben , Chamorro-Mera Antonio , Diaz-Mendez Montserrat
Published: December 2023

This article addresses students’ value co-creation behaviour, framed by the Service-Dominant logic approach, within the context of the marketization of the higher education service ecosystem. The objective is to explore how students integrate their cognitive and behavioural activities during their academic trajectory. The study surveyed 375 first-year undergraduate students, all with weighted grade point averages (GPA) in the range of 8.5 to 9.5 out of 10, at a public university in Mexico, a region characterized by a strong presence of the prevalent passive customer-student analogy tendency. A principal component analysis was also conducted to assess the grouping of the eight original dimensions included in the scale implemented for this ecosystem. In addition, a non-hierarchical cluster analysis was employed to categorize the students according to their co-creation behaviour. The results identify three segments of students: the first with a high willingness to cocreate value, the second characterized by a proactive attitude but lack of interest in relationships with peers and teachers, and the third characterized by a low level of co-creation in all dimensions assessed. These findings highlight that not all students engage in co-creation behaviours during their academic pursuits, even when they achieve outstanding grades. The results suggest some considerations for operationalizing value co-creation in the context of the educational service ecosystem, highlighting its implementation as a dynamic and nonlinear process, considering predelivery and postdelivery. It also highlights the relevance of involving students in activities beyond traditional activities during their service experience. Finally, this study stresses the need to adopt a long-term perspective rather than seek immediate student satisfaction, suggesting the importance of designing more sustainable educational policies and strategies.
Evolving landscape of artificial intelligence (AI) and assessment in education: A bibliometric analysis
Authors: TAŞKIN BEDİZEL Nazlı Ruya
Published: December 2023

The rapid evolution of digital technologies and computer sciences is ushering society into a technologically driven future where machines continually advance to meet human needs and enhance their own intelligence. Among these groundbreaking innovations, Artificial Intelligence (AI) is a cornerstone technology with far-reaching implications. This study undertakes a bibliometric review to investigate contemporary AI and assessment topics in education, aiming to delineate its evolving scope. The Web of Science Databases provided the articles for analysis, spanning from 1994 to September 2023. The study seeks to address research questions about prominent publication years, authors, countries, universities, journals, citation topics, and highly cited articles. The study’s findings illuminate the dynamic nature of AI in educational assessment research, with AI firmly establishing itself as a vital component of education. The study underscores global collaboration, anticipates emerging technologies, and highlights pedagogical implications. Prominent trends emphasize machine learning, Chat GPT, and their application in higher education and medical education, affirming AI's transformative potential. Nevertheless, it is essential to acknowledge the limitations of this study, including data currency and the evolving nature of AI in education. Nonetheless, AI applications are poised to remain a prominent concern in educational technology for the foreseeable future, promising innovative solutions and insights.
Caracterización de la propaganda electoral de la candidata Delfina Gómez al gobierno del Estado de México mediante el uso y evaluación de la Biblioteca de Anuncios de Meta
Authors: Acosta Valverde Miguel , López Aguirre José Luis , Ortiz Sergio Julio , Maya Méndez Daniel Isaac , Pérez Jiménez Daniel Alejandro
Published: December 2023

La campaña electoral por la gubernatura del Estado de México realizada a mediados del 2023 se sitúa entre las más relevantes de la política mexicana contemporánea: se trata de la entidad con el mayor número de votantes registrados en el país, por primera vez en la historia contendieron dos mujeres y además el Partido Revolucionario Institucional se jugaba casi un siglo de gobernar dicho estado. Sin embargo, fue otro asunto el que resultó ser relevante para esta investigación: candidatos y candidatas en México están incrementando la propaganda electoral en las redes sociodigitales para promover su imagen y persuadir especialmente a las jóvenes audiencias. Por ello, se decidió analizar, mediante una metodología híbrida, un corpus selectivo de anuncios electorales publicados en Facebook por la candidata y actual gobernadora Delfina Gómez, con el propósito de distinguir sus principales características e identificar qué tipo de anuncios tuvieron mayor importancia en Facebook. Asimismo, esta investigación permitió evaluar los atributos y limitaciones de la Biblioteca de Anuncios de Meta.
Subjetividad enunciativa y análisis del efecto pathémico en las publicaciones de Twitter (X) de los candidatos a Gobernador de Coahuila 2023
Authors: Gómez Aguilera Blanca Nahayeli , Minor Cervantes Crysta Natalia , Hernández Fernández Alan Alberto
Published: December 2023

Las emociones y subjetividades son un componente para la toma de decisiones, en contextos de coyunturas políticas, suelen ser decisivas para que los políticos logren persuadir y seducir al electorado con el fin de obtener el voto. Este artículo presenta un análisis del discurso de la segunda quincena de abril de las publicaciones en Twitter (X) de los candidatos a Gobernador de Coahuila 2023: Manolo Jiménez y Armando Guadiana. Partimos de la perspectiva de la retórica digital como propuesta de intervención mixta en la recuperación del corpus y en el posterior análisis cualitativo de la categoría del pathos para encontrar el efecto pathémico como propósito de persuasión. Respondemos a las interrogantes: ¿Cuál es el papel que juegan las pasiones en las publicaciones de los candidatos a la gubernatura de Coahuila en 2023? ¿Cuáles son los recursos lingüísticos que buscan apelar a las emociones del posible electorado por parte de los políticos? El objetivo central es identificar y describir qué efectos pathémicos subyacen en las publicaciones como estrategias de comunicación política local. Encontramos como resultado que la campaña ofrece una agenda influencer en donde hay poco compromiso y responsabilidad por parte de los políticos en canales de comunicación digital, pues no comparten propuestas de campaña y en su lugar, buscan exaltar emociones que apelan a la felicidad y a la enunciación de lavictoria mediante frases coloquiales, metáforas e hipérboles. Concluimos que hay una ausencia de campaña electoral en las enunciaciones de los candidatos a Gobernador de Coahuila, que no coindice con la utilización de un canal de comunicación para informar sobre propuestas a los ciudadanos.
LA INTELIGENCIA EMOCIONAL EN ESTUDIANTES UNIVERSITARIOS DE PEDAGOGÍA VERACRUZ, MÉXICO
Authors: Sánchez Zamudio María del Carmen
Published: December 2023

El objetivo de este estudio es analizar la respuesta de los estudiantes universitarios de acuerdo con la percepción, asimilación, comprensión y regulación de sus emociones ante situaciones diversas que se les presentan, mediante un enfoque cuantitativo y un diseño exploratorio de una muestra de los grupos de dos generaciones, con un total de 62 participantes. Se aplicó la técnica de encuesta y empleó un cuestionario para medir la inteligencia emocional, mediante la escala (ESCQ) Habilidades emocionales y competencias, que exploró cuatro categorías en particular del modelo de Mayer y Salovey (1997): percepción, asimilación, comprensión y regulación de las emociones. Consta de 45 ítems, en una escala de tipo Likert, con una valoración de 1 a 5. Para el tratamiento de la información, se analizaron los datos mediante comparación de medias en la prueba de Anova. Los resultados señalan que el factor generación no influye en el comportamiento de las dimensiones de IE, por lo que no se reporta una diferencia significativa. Las conclusiones señalan que se presentan necesidades más latentes en la percepción y regulación de sus emociones; esto pudiera conllevar ciertas afectaciones en la vida personal y profesional. Después de adentrarse al campo, se considera fundamental continuar con esta línea de investigación e incorporar nuevas hipótesis de estudio.
LA EDUCACIÓN COMO PILAR PARA LA REINSERCIÓN SOCIAL. EDUCACIÓN EN CONTEXTO DE ENCIERRO EN EL ÁMBITO DE LA REPÚBLICA ARGENTINA
Authors: Palacin Guido Adrián , Álvarez María Gabriela
Published: December 2023

El presente artículo desarrollará qué se entiende por «derecho a la educación» y cómo está regulado específicamente en los contextos de encierro, teniendo en cuenta cómo opera el estímulo educativo reglado en el artículo 140 de la Ley 24.660 y su importancia en el proceso de reinserción social de los internos. Se hará una comparación entre lo que sanciona la Ley de Educación Nacional y los instrumentos internacionales en materia de derechos humanos –con jerarquía constitucional–, que respaldan este derecho y con lo que realmente sucede en el sistema penitenciario. Asimismo, se analizará la jurisprudencia argentina en la que se reconoce el derecho a la educación de las personas privadas de libertad y su importancia para el sistema de progresividad que regula la ley de ejecución penal. Por otro lado, se analizará cómo, en la práctica, ha perdido virtualidad la reducción que regula el artículo 140, al haberse introducido un grupo de delitos impedidos de acceder a los institutos liberatorios, mediante la Ley 27.375. El objetivo central recae en la necesidad de remarcar que la educación, en contextos de encierro, es fundamental para la reinserción social y que el Estado tiene la obligación de garantizar este derecho.
FROM ANXIETY TO ATARAXIA
Authors: Pohoață Gabriela
Published: December 2023

Our analysis starts from the premise that anxiety is a philosophical concept, not merely a research topic for psychology, not being reducible only to anxiety neurosis. Thus, we propose the philosophical research of this particularly deep concept requiring a complex approach due to its metaphysical origin and its link to the spirit, to he human being's basic structure. It is also the reason why we appreciate that the solution to the problem of anxiety is eminently spiritual, more specifically, it resides in the ‘awakening of the spirit’. A truly free spirit, even if dominated by metaphysical anxieties, cannot lock itself into destructive anxiety. In my opinion, metaphysical anxiety cannot be confused with depression, it cannot be treated with anti-depressants. Did man not have turmoil, metaphysical anxieties, he could not claim to participate in culture. Only the one who goes through metaphysical anxiety can attain the state of ataraxia.
Detecting drought-prone regions through drought indices
Authors: Pawar Sangita , Shelke Mahesh , Kushare Nikita
Published: December 2023

Climate change has led to heightened variability in global rainfall patterns, resulting in greater unpredictability and inconsistency, and it has led to the origin of meteorological drought situation. This has amplified the frequency of droughts or drought-like conditions worldwide. India, being primarily agrarian, faces significant challenges due to drought, affecting various regions intermittently. Given the urgency of addressing recurring drought issues, it is crucial to determine specific ‘drought-prone’ areas through the analysis of historical and current meteorological data. It is still a challenge to quantitatively understand where and to what extent the impact of rainfall patterns could lead the drought. Whether any region likely comes under drought-prone area or not? Can we help policy makers to apply their knowledge effectively? It will help to undertake the long-term mitigation measures for drought assessment and management which encompasses early warning, monitoring, and relief toward the good health of the society. The present study is a further step in the same direction in which Akola district in Maharashtra, India has been assessed for drought-prone declaration using two drought measuring indices; seasonality index (SI) and aridity index (AI). For this, the measured meteorological data precipitation, and potential evapotranspiration, from 1952 to 2002 is made available from India Water Portal.
Ethics of Solidarity Fr. Józef Tischner in the Education of the 21st Century
Authors: Dąbrowski Szymon
Published: December 2023

Artykuł poświęcony jest badaniom z zakresu fenomenologii społecznej ks. Józefa Tischnera (1931-2000), w których to jednym z najistotniejszych zagadnień jest Etyka solidarności, rozumiana tu jako Etyka sumień. Podstawowym założeniem tekstu było uznanie projektu Etyki solidarności jako źródłowo zaangażowanego społecznie, a także pedagogicznie. Co za tym idzie, celem najistotniejszym jest tu ujawnienie wewnętrznego potencjału powyższej propozycji dla analiz z zakresu pedagogiki ogólnej i społecznej. W roku 2021 minęła 90-ta rocznica urodzin Autora oraz 40-ta rocznica pierwszego wydania Etyki solidarności (1981), co stało się to dobrą okazją do rekonstrukcji podstawowych tez omawianego projektu, ale również próbą wskazania potencjału edukacyjnego, przy szczególnym uwzględnieniu problematyki społecznej w dobie wyzwań postawionych przed społeczeństwem demokratycznym w XXI wieku w Polsce i Europie.
1,3,4-Thiadiazole: A Versatile Scaffold for Drug Discovery
Authors: Mittal Ravi K. , Mishra Raghav , Sharma Vikram , Mishra Isha
Published: December 2023

1,3,4-Thiadiazole has garnered considerable attention in the scientific community due to
its captivating molecular structure and ability to serve as a foundation for creating novel pharmaceutical
compounds. Numerous medications feature the 1,3,4-thiadiazole ring in their chemical structure,
highlighting its relevance and efficacy in pharmaceutical research and development. The key
objective of this comprehensive review is to provide an understandable overview of the chemistry
and diverse pharmacological activities associated with 1,3,4-thiadiazole compounds. The manuscript
was compiled by conducting a thorough literature review, which included an in-depth analysis of
globally esteemed scientific research databases. The remarkable chemical characteristics and diverse
pharmacological impacts of 1,3,4-Thiadiazole highlight its significant potential as a structural scaffold
for the development of novel therapeutic substances. Based on the information available on synthetic
molecules that incorporate the 1,3,4-thiadiazole framework and their wide range of uses, it is
reasonable to expect significant advancements in the near future and the possibility of employing
these compounds in different domains.
Strategies for Promoting Positive Childbirth Experiences: Delphi
Approach
Authors: Shahhosseini Zohreh , Motaghi Zahra , Keramat Afsaneh , Kolahdozan Sakineh , Hosseini Tabaghdehi Leila , Moosazadeh Mahmood , Hosseini Tabaghdehi Monirolsadate
Published: December 2023

Background::

The experiences that women gain during childbirth remain with them
throughout life. This study aimed to provide strategies to promote positive childbirth experiences.

Method::

This Delphi study was conducted in three rounds from September to November 2019. A
purposively selected 17 national experts, including obstetricians, reproductive health professionals,
and midwives, participated in this study.

Results::

Most of the 52 initial strategies in the first round (50 strategies) were approved with a
few corrections in the first and second rounds, and 23 strategies were presented in the third-round
questionnaire; most panelists agreed upon them. Finally, they approved 73 strategies with five categories:
promoting professional support, enhancing control skills, encouraging empowerment, promoting
spouse and other important support, and improving childbirth preparation.

Conclusion::

The Delphi approach allows for developing a consensus that will serve as a template
for education, practice, and future research in maternity care units. Hence, multidimensional approaches
are required to promote positive childbirth experiences that can potentially improve
mothers’ well-being outcomes.
Preparation and Optimization of Gemcitabine Loaded PLGA Nanoparticle Using Box-Behnken Design for Targeting to Brain: In Vitro Characterization, Cytotoxicity and Apoptosis Study
Authors: Alik Kumar Ladi , Pattnaik Gurudutta , Satapathy Bhabani Sankar , Mohanty Dibyalochan , Prasanth P.A. , Dey Suddhasattya , Debata Jitendra
Published: December 2023

Background:

Treatment of glioma with conventional approaches remains a far-reaching target to provide the desired outcome. This study aimed to develop and optimize Gemcitabine hydrochloride- loaded PLGA nanoparticles (GNPs) using the Box-Behnken design methodology. The independent variables chosen for this study included the quantity of Polymer (PLGA) (X1), Tween 80 (X2), and Sonication time (X3), whereas the dependent variables were Particle size (Y1) EE % (Y2) and PDI (Y3). The optimized biodegradable nanoparticles were investigated for their anticancer effectiveness in U87MG human glioblastoma cells in vitro.

Method:

The formulation process involved two steps. Initially, emulsification was carried out by combining the organic polymer solution with the aqueous surfactant solution. Subsequently, in the second step, the organic solvent was evaporated, resulting in the precipitation of the polymer and the formation of nanoparticles. The quantity of PLGA, Tween 80, and PVA (at a constant concentration) was adjusted based on the experimental trial approach. Subsequently, the PLGA-based nanoparticles underwent characterization, wherein their particle size, encapsulation efficiency, polydispersity index (PDI), and cumulative release were assessed. The optimal formulation composition was determined as 200 mg of PLGA, 4 ml of Tween 80, and 2 mg of PVA. Further, the optimized GNPs were evaluated for their anti-cancer effectiveness on U87 MG cells by MTT and apoptosis assay.

Results:

The results demonstrated that the optimized GNPs exhibited an encapsulation efficiency of 81.66 %, a particle size of 140.1 nm, and a PDI of 0.37. The morphology of the Opt-GNPs was observed to be spherical through transmission electron microscopy (TEM).

Conclusion:

The Apoptosis study further confirmed the observations of MTT assay as the Opt- GNPs significantly enhanced the apoptosis in U-87 MG cells than the Standard marketed formulation.
Chitosan-based Nanomedicine in the Management of Age-related Macular Degeneration: A Review
Authors: Mukherjee Swarupananda , Karati Dipanjan , Singh Sudarshan , Prajapati Bhupendra G.
Published: December 2023

Age-related macular degeneration (AMD) is a leading cause of permanent blindness globally. Due to the various obstacles, highly invasive intravitreal (IVT) injections are the prima-ry method used to deliver medications to the tissues of the posterior eye. An utmost patient-friendly topical ocular delivery approach has been extensively researched in recent years. Muco-adhesive compositions extend precorneal residence time while reducing precorneal clearance. They increase the likelihood of adhesion to corneal and conjunctival surfaces and, as a result, al-low for enhanced delivery to the posterior eye segment. Due to its remarkable mucoadhesive characteristics, chitosan (CS) has undergone the most extensive research of any mucoadhesive polymer. Drug delivery to the front and back of the eye is still difficult. The pharmaceutical in-dustry has shown greater interest in drug delivery systems (DDSs) based on nanotechnology (NT) in recent years, particularly those made from natural polymers like chitosan, alginate, etc. Be-cause of their incredible adaptability, higher biological effects, and favourable physicochemical properties, CS-oriented nanomaterials (NMs) are explored by researchers as prospective nanocar-riers. CS are the right substrates to develop pharmaceutical products, such as hydrogels, nanopar-ticles (NP), microparticles, and nanofibers, whether used alone or in composite form. CS-based nanocarriers deliver medicine, such as peptides, growth factors, vaccines, and genetic materials in regulated and targeted form. This review highlights current developments and challenges in chi-tosan-mediated nano therapies associated with AMD.
Precariat as a result of personalizing modern social, labor and personal practices
Authors: Oliinyk Ivan
Published: December 2023

The author analyzes the manifestations of social precariousness practices in mo­dern social and labor relations. The analysis is carried out in three methodological directions: political (the formation of the precariat is determined by political factors); economic and technological (precarious practices are considered from the point of view of economic flexibility); functionalist (fixation of an individual’s psychological characteristics specific to precarious practices is carried out). It is proved that it is the functional approach that gives grounds for further considerations regarding the life strategies chosen by the precariats, as well as their attitude to the state as the main source of their problems. It was revealed that the combination of a high protest potential with a low ability to organize makes the precariat an environment where, against the background of a low material status, fear and uncertainty about one's future can generate extreme forms of reaction to them – from the conforming acceptance in an individual order of the labor relations’ formats, which are provoked by employers, to spontaneous mass protests, which, however, are not able to eliminate the causes of precariousness, but often turn into trashes, intensified by inter-racial and inter-confessional contradictions
Święty Józef Sebastian Pelczar a przemyscy salezjanie
Authors: Szal Adam
Published: December 2023

The article discusses the connections between the bishop of Przemyśl, St Joseph Sebastian Pelczar, and the Salesians of Przemyśl. The first part of the paper reveals the main facts from the bishop's life, his major pastoral achievements, concern for the condition of the clergy and religious orders as well as various socio-educational initiatives. This coincided with the growth of the Salesian congregation founded by St John Bosco in Turin in 1859. Its crucial mission was educational work among children and youth. An attempt to resolve the conflict between the religious authorities of the Salesians and Fr Bronisław Markiewicz created an opportunity for Bishop Pelczar to make contact with the then-general of the Salesians, Fr Michael Rua. Consequently, Bishop Pelczar visited the Salesian facility in Oświęcim and learned about their educational work there. As a result, the Salesians were invited to open a facility in Przemyśl. The first group led by Fr August Hlond (later Primate of Poland) arrived in Przemyśl before the 27th of July 1907, which laid the foundations for future educational work and a parish. The last part of the paper briefly describes the history of the facility and the new church in the area funded by Bishop Pelczar.
Początki działalności salezjanów w Przemyślu
Authors: Pietrzykowski Jan
Published: December 2023

Przemyśl, where the Salesians arrived in 1907, has been one of the pioneering establishments in the Polish territories under the Austrian Partition. On the initiative of the diocesan bishop - St. Józef Sebastian Pelczar, they settled in the Zasanie district, which, at that time, had no parish yet, but there were several religious houses. First Salesians who served there cared for young people by running an oratory and teaching religion to children and young people in schools. In modest conditions in a home chapel, they performed pastoral service for the local faithful. A specific stabilization is evidenced by the completion of the youth and religious houses and the commissioning of rooms for the needs of the boarding School of Organists opened in 1916. The culmination of the preparation of the base for pastoral and youth work was the construction and commissioning of the church for the use of the faithful and the establishment of the parish in Zasanie district of Przemyśl. In 1917-1939, the Salesians ran an orphanage in the left-bank part of the city, where they possessed a separate religious house.
Salezjanie muzycy w Przemyślu (do 1975 roku): wstęp do badań nad dorobkiem muzycznym
Authors: Ślusarczyk Tomasza
Published: December 2023

The paper provides a general outline of the educational system in the Salesian Organ School in Przemyśl and discusses its impact on the growth of St Joseph parish in the city. Teaching staff is characterized, especially the figures of Fr Antoni Chlondowski, Fr Augustyn Piechura and Fr Antoni Śródka.
Disorders of cardiac conduction and rhythm in patients with rheumatoid arthritis
Authors: Rebrov A. P.
Published: December 2023

The article presents data on the frequency and features of the development of various cardiac conduction and rhythm disorders in patients with rheumatoid arthritis, the mechanisms of development of these disorders, and discusses the role of inflammation, atrial remodeling, dysfunction of the autonomic nervous system, activation of the renin-angiotensin system, endothelial dysfunction and other factors.
Analysis of growth differentiation factor-15 at the hospital stage of treatment of patients with acute myocardial infarction
Authors: Khorolets E. V. , Akhverdieva M. K. , Shlyk S. V.
Published: December 2023

Objective: to dynamically study the clinical characteristics, the level of growth differentiation factor 15 (GDF-15) during hospital treatment in patients with acute ST-segment elevation myocardial infarction (STEMI). Materials and methods: an analysis of clinical and laboratory data of STEMI patients during hospital treatment and echocardiography parameters was carried out. Scores were calculated on the GRACE scale to assess the prognosis of in-hospital mortality of patients. The characteristics of patients with STEMI were identified taking into account GDF-15 values. Statistical processing using the statistical software package "Statistica 10.0 for Windows". Results: clinical and laboratory characteristics of STEMI patients on the first day of the disease determined the prognosis. GDF-15 values increased on the first day of STEMI development and depended on the risk of in-hospital mortality on the GRACE scale. GDF-15 values tended to decrease during the inpatient phase of treatment. Patients with STEMI with a GDF-15 concentration equal to or more than 1200 ng/ml did not reach reference values in the dynamics of hospital treatment and had higher values of markers of myocardial necrosis, reflecting the impact on the prognosis. Conclusion: the GDF-15 indicator can be used as a marker for the prognosis of STEMI in combination with the GRACE scale assessment. High GDF-15 values during the hospital phase of patient treatment reflect the prognosis of STEMI patients.
Pharmacotherapy for hypertrophic cardiomyopathy
Authors: Ignatenko G. A. , Taradin G. G. , Kononenko L. V.
Published: December 2023

The presented review concerns modern approaches to drug therapy for hypertrophic cardiomyopathy. General issues of the treatment are touched upon, including lifestyle modification, maintaining adequate hydration and avoiding situations that increase obstruction. The role of traditionally used b-blockers and non-dihydropyridine calcium channel blockers in the treatment of the disease is described. Data on the use of disopyramide are presented, the treatment of which allows reducing the obstruction gradient, ameliorating clinical manifestations and improving diastolic function. Special attention is paid to a new class of drugs — cardiac myosin inhibitors: mavacamten and aficamten. The results of randomized clinical trials regarding to evaluating the efficacy of these drugs are reported. The review presents a modern view of the place of perhexiline, trimetazidine, ranolazine, eleclazine, angiotensin II receptor blockers, combination of sacubitril and valsartan in the therapy of hypertrophic cardiomyopathy.
Wegener's granulomatosis: difficulties in diagnosis and treatment
Authors: Baranova Y. R. , Romanova I. A. , Steshenko R. N. , Melehina I. F. , Nikitina N. N. , Karoli N. A.
Published: December 2023

Granulomatosis with polyangiitis (Wegener's granulomatosis, GPA) is a rare disease of unknown etiology with multiple organ lesions, characterized by the development of necrotizing granulomatous inflammation and signs of autoimmune vasculitis, predominantly affecting small and medium-sized vessels. In the above clinical case, the patient has a classic triad of symptoms (damage to the upper respiratory tract, lungs, kidneys), the diagnosis was confirmed morphologically. The peculiarity of the described clinical case is its rare prevalence, the difficulty in making a diagnosis due to the multiorganism of the lesion, the absence of specific signs at the onset of the disease, which required a differential diagnosis. Early detection of antineutrophil cytoplasmic antibodies (ANCA) in the blood increases the frequency of GPA diagnosis, and timely diagnosis allows prescribing therapy as soon as possible and avoiding disability in patients.
Identification of Hypertension in Electronic Health Records Through Computable Phenotype Development and Validation for Use in Public Health Surveillance: Retrospective Study (Preprint)
Authors: Valvi Nimish , McFarlane Timothy , Allen Katie S , Gibson P Joseph , Dixon Brian Edward
Published: December 2023

BACKGROUND

Electronic health record (EHR) systems are widely used in the United States to document care delivery and outcomes. Health information exchange (HIE) networks, which integrate EHR data from the various health care providers treating patients, are increasingly used to analyze population-level data. Existing methods for population health surveillance of essential hypertension by public health authorities may be complemented using EHR data from HIE networks to characterize disease burden at the community level.

OBJECTIVE

We aimed to derive and validate computable phenotypes (CPs) to estimate hypertension prevalence for population-based surveillance using an HIE network.

METHODS

Using existing data available from an HIE network, we developed 6 candidate CPs for essential (primary) hypertension in an adult population from a medium-sized Midwestern metropolitan area in the United States. A total of 2 independent clinician reviewers validated the phenotypes through a manual chart review of 150 randomly selected patient records. We assessed the precision of CPs by calculating sensitivity, specificity, positive predictive value (PPV), F1-score, and validity of chart reviews using prevalence-adjusted bias-adjusted κ. We further used the most balanced CP to estimate the prevalence of hypertension in the population.

RESULTS

Among a cohort of 548,232 adults, 6 CPs produced PPVs ranging from 71% (95% CI 64.3%-76.9%) to 95.7% (95% CI 84.9%-98.9%). The F1-score ranged from 0.40 to 0.91. The prevalence-adjusted bias-adjusted κ revealed a high percentage agreement of 0.88 for hypertension. Similarly, interrater agreement for individual phenotype determination demonstrated substantial agreement (range 0.70-0.88) for all 6 phenotypes examined. A phenotype based solely on diagnostic codes possessed reasonable performance (F1-score=0.63; PPV=95.1%) but was imbalanced with low sensitivity (47.6%). The most balanced phenotype (F1-score=0.91; PPV=83.5%) included diagnosis, blood pressure measurements, and medications and identified 210,764 (38.4%) individuals with hypertension during the study period (2014-2015).

CONCLUSIONS

We identified several high-performing phenotypes to identify essential hypertension prevalence for local public health surveillance using EHR data. Given the increasing availability of EHR systems in the United States and other nations, leveraging EHR data has the potential to enhance surveillance of chronic disease in health systems and communities. Yet given variability in performance, public health authorities will need to decide whether to seek optimal balance or declare a preference for algorithms that lean toward sensitivity or specificity to estimate population prevalence of disease.
Improving Pediatric Patients’ Magnetic Resonance Imaging Experience With an In-Bore Solution: Design and Usability Study (Preprint)
Authors: Heuvelink Annerieke , Saini Privender , Taşar Özgür , Nauts Sanne
Published: December 2023

BACKGROUND

Annually, millions of children undergo a magnetic resonance imaging (MRI) examination. Hospitals increasingly aim to scan young children awake, as doing so benefits both patients and health care systems. To help hospitals reduce the need for anesthesia, we have developed solutions to prepare pediatric patients at home and in the hospital.

OBJECTIVE

The goal of our project was to design, develop, and test a solution that extends our preparation solutions by guiding and engaging children during their MRI examination.

METHODS

Pediatric In-bore was designed to deliver a familiar experience by reusing design elements from our preparation solutions. It offers child-friendly movies and auditory and visual guidance about examination progress and breath holding. To evaluate children’s liking and understanding of the solution, we conducted a usability study. Ten healthy children participated in a mock MRI examination featuring pediatric In-bore. We observed task compliance (ability to lie still and hold one’s breath) and conducted guided interviews to assess their experience and understanding of the guidance offered.

RESULTS

Participants (aged 5 to 10 years) were generally positive about pediatric In-bore. They liked the main character (Ollie the elephant) and her movie. Auditory and visual guidance were generally liked and understood. All but one participant successfully managed to lie still during the mock examination, and 6 (60%) out of 10 participants successfully held their breath.

CONCLUSIONS

Pediatric In-bore appears promising for engaging and guiding young children during awake MRI. It completes the Pediatric Coaching solution that now offers guidance throughout the MRI journey. Future research can expand on this work by evaluating the clinical impact of the Pediatric Coaching solution in a larger and more diverse sample of pediatric patients.
Characterization, therapeutic applications, structures, and futures aspects of marine bioactive peptides
Authors: Ashraf Azqa , Ud Din Aiman Salah , Hussain Mudassar , Khan Imad , Hassan Farazia , Ahmad Adnan , AL-Ansi Waleed , Lou Zaixiang
Published: December 2023

Bioactive peptides from marine species have gained attention due to their promising biological features, and the disciplines of pharmaceutical, cosmeceutical, nutraceutical, and biomedical product development have increased recently. Their molecular mass, immunity, and natural abilities that they evolved are essential for host defense mechanisms. Marine bioactive peptides have extremely complex and diverse structures that vary greatly depending on the sources from which they are obtained. They frequently have secondary structures and can be cyclic in the form of depsi-peptides. Bioactive peptide purification from marine sources can be achieved via chromatography techniques, including reverse-phase high-performance liquid chromatography, gel filtration chromatography, and ion exchange chromatography, which is a current technique to extract biologically active peptides. Studies of marine plants, microbes, and animals over the last several eras have revealed a huge variety of structurally varied and bioactive secondary metabolites. With a particular focus on the conversion of nutraceutical and pharmaceutical research into commercially available products, this review summarizes current findings in marine peptide research as well as emerging patterns, and its promising directions are briefly reviewed. The use of active peptides derived from the sources mentioned earlier their health advantages and bioactivities are also focused. Along with safety concerns, their possible usages in the processed food industry, wound healing, feed, cosmetic, and pharmaceutical industries, for the growth of efficient goods, are highlighted.
ФОРМИРОВАНИЕ ПАКЕТА ДАННЫХ КООРДИНАТНЫХ ИЗМЕРЕНИЙ НА ПРИБОРАХ КОНТРОЛЯ ФОРМЫ, КОНТУРА, МЕСТОРАСПОЛОЖЕНИЯ
Authors: Епифанцев К.
Published: December 2023

Процесс измерения деталей на высокоточном оборудовании имеет
ряд проблем, которые сводятся к усреднению показаний, доводки
измерений с помощью цифровых фильтров до ближайшего среднего
результата, что не всегда удобно, если стоит задача измерить мгновенное
значение. Это было бы возможно на аналоговых приборах. В статье
обсуждается вопрос аналогичных причин, которые могут стать следствием
погрешности измерений на КИМ (координатно-измерительной
машине).
ОБЗОР ОТЕЧЕСТВЕННЫХ КОМПЬЮТЕРНЫХ МОДУЛЕЙ ФОРМАТА SMARC
Authors: Медведев А.
Published: December 2023

Компьютерные модули, называемые также компьютерами на
модуле (Computer-on-Module),
или системами на модуле (System-on-Module),
представляют собой компактный вычислитель, содержащий
центральный процессор, память, контроллеры периферии и вторичные
источники питания. Все периферийные интерфейсы выведены
на разъемы в соответствии с общепринятыми спецификациями.
Компьютерные модули широко применяются как для решения тех
задач, которые невозможно эффективно решить с помощью стандартных
встраиваемых плат, так и для обновления устаревших систем.
Описание наиболее популярных среди разработчиков и пользователей
встраиваемых систем стандартов компьютерных модулей (ETX,
Qseven, SMARC, СOM Express и COM-HPC) представлено в публикации
«Компьютерные модули: преимущества применения и популярные
стандарты»*. В настоящей статье приведено описание одного из
самых «молодых» стандартов: SMARC, а также краткая информация
об отечественных производителях, выпускающих модули в данном
стандарте, и их продукции.
HEIDEGGER’S UNDERSTANDING OF ART IN THE ESSAY THE ORIGIN OF THE WORK OF ART
Authors: Glasnović Kamenović Marija
Published: December 2023

The paper analyzes Heidegger's understanding of art, presented in the essay The Origin of the Work of Art. The research is divided into two parts: destructive, dedicated to the exposition of Heidegger's understanding of the process of aestheticization and criticism of modern aesthetics, and constructive, which presents a detailed analysis of Heidegger's understanding of art and the work of art. Although in the first part, Heidegger claims that the Hegelian thesis about the end of art has merit, as he finds that aestheticization is a process in which the work of art disappears into experience, in the second part, Heidegger opens up space for its reconsideration and thus introduces the thesis about defiant potential of art and the possibility for expelling representation and metaphysical aesthetics. This is why Heidegger begins a complex analysis of the way of being of the work of art, which is first opened in contrast to the being of thing and the being of equipment. The research reveals that the work of art should be understood within the dialectics of the world and the earth, through the concept of truth as aletheia, and concludes that art is simultaneously the truth's setting-itself-into-work and the setting-of-truth-into-the-work. Heidegger's double definition of art suggests the introduction of a balance between the reflexive and revolutionary understanding of art, between the autonomy of the work and the need for the artist and the audience, and the ontological determinations of throwness and projection. In the end, the examination of the origin of a work of art shows that art itself is a kind of origin from which the truth as unconcealment springs.
APPLICATION OF RENOVATION MODEL IN TEACHING OF HARMONY
Authors: Nagorni Petrov Nataša , Stojanović Danijela
Published: December 2023

Practical harmonization on an instrument within the Harmony course is continuously an element of professional musical education, from the first grade of the secondary music school to the completion of bachelor studies of music. The manners, means, methods, as well as the degree and approach to this technique (skill) are naturally and inevitably open to new ideas. The paper presents the renovation potential of the specific Medieval Church scales (modes), sequences, transpositions, and modulations, as the terms and techniques familiar to the students within the course of Harmony. The application of the recommended procedures of the renovation model in teaching Harmony is one of the possible ways to accomplish successful and creative classes in this interesting and inspiring area of musical expression for students, allowing for more successful transfer and presentation of the acquired knowledge and opening doors to their potential creativity.