bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring access to health and social supports for intimate partner violence (IPV) survivors during stressful life events (SLEs)—A scoping review
Authors: Idriss-Wheeler Dina , Bancroft Xaand , Bouraleh Saredo , Buy Marie , Yaya Sanni , El-Khatib Ziad
Published: December 2024

Background

Survivors of intimate partner violence (IPV) often face increased incidents of violence during stressful life events (SLEs) such as economic recessions, environmental disasters, and pandemics. These events can diminish the effectiveness of both formal (e.g., health, social, justice, labor, community) and informal (e.g., friends, family, neighbors) support systems. Additionally, SLEs exacerbate existing health and social inequities, making it necessary to understand the accessibility of support services during these times. This scoping review investigates access to services by individuals experiencing IPV during SLEs in high-income countries.

Approach

A comprehensive search was conducted across several electronic databases including MEDLINE (OVID), Embase (OVID), PsychInfo (OVID), CINAHL (EBSCO), Global Health (EBSCO), Gender Watch (ProQuest), Web of Science, and Applied Social Sciences Index & Abstracts (ProQuest), along with the search engine Google Scholar. This search, which imposed no date restrictions, was extended through May 22nd, 2024. Key search terms were developed from prior literature and in consultation with an expert librarian, focusing on ‘stressful life events,’ ‘intimate partner violence,’ and ‘access to services.’. Each study was screened and extracted by two reviewers and conflicts were resolved through discussion or a third reviewer.

Results

The search across eight databases and citation searching resulted in a total of 7396 potentially relevant articles. After removing 1968 duplicates and screening 5428 based on titles and abstracts, 200 articles underwent full abstract review. Ultimately, 74 articles satisfied the inclusion criteria and were selected for further analysis. The analysis focused on barriers and facilitators to access, identifying challenges within Survivors’ support systems, redirected resources during crises, and complex control dynamics and marginalization. Over 90% of the literature included covered the recent COVID-19 pandemic. Addressing these challenges requires innovative strategies, sustained funding, and targeted interventions for high-risk subgroups.

Conclusion

This scoping review systematically outlined the challenges and enabling factors influencing the availability of support services for Survivors of IPV during SLEs. It underscores the need for robust, culturally sensitive health and social support mechanisms, and policies. Such measures are essential to better protect and assist IPV Survivors and their service providers during these critical times. Furthermore, it is imperative to integrate the insights and expertise of the violence against women (VAW) sector into emergency planning and policy-making to ensure comprehensive and effective responses that address the unique needs of Survivors in crises.
The effect of problem-based learning on improving problem-solving, self-directed learning, and critical thinking ability for the pharmacy students: A randomized controlled trial and meta-analysis
Authors: Chen Tu , Zhao Yi-Jing , Huang Feng-Qing , Liu Qun , Li Ying , Alolga Raphael N. , Zhang Lei , Ma Gaoxiang
Published: December 2024

Objective

This study aimed to comprehensively evaluate the effect of PBL on problem-solving, self-directed learning, and critical thinking ability of pharmaceutical students through a randomized controlled trial (RCT) and meta-analysis of RCTs.

Methods

In 2021, 57 third-year pharmacy students from China Pharmaceutical University were randomly divided into a PBL group and a lecture-based learning (LBL) group. Mean scores were compared between the two groups for problem-solving, self-directed learning, communication skills, critical thinking, and final exam grades. Students’ feedback on the implementation of PBL was also collected. A meta-analysis was subsequently performed. Two authors independently conducted a comprehensive search of two databases (PubMed and CNKI). Eligible studies with effective data were included and the valuable data were extracted for analysis. Quality of involved studies was assessed by the Cochrane Collaboration’s tool. All analyses of statistics were conducted using the ‘metafor’ package in R software.

Results

The PBL group had significantly higher mean scores for problem-solving (8.43±1.56) and self-directed learning (7.39±1.19) than the LBL group (7.02±1.72 and 6.41±1.28, respectively). The PBL group also showed better communication skills (8.86±1.47) than the LBL group (7.68±1.89). The mean level of critical thinking was significantly higher in the PBL group than the LBL group (p = 0.02). The PBL group also had better final exam grades (79.86±1.38) compared to the LBL group (68.1±1.76). Student feedback on PBL implementation was positive. The outcome of subsequent meta-analysis including 8 eligible studies involved 1819 participants showed that the use of PBL significantly improved problem-solving ability (SMD = 1.12, 95% CI = 0.25–1.99) and PBL was also associated with better performance in self-directed learning (SMD = 1.55, 95% CI = 0.64–2.45). However, there was no significant difference in the final exam score in the PBL group compared to the LBL control group (SMD = 0.23, 95% CI = -0.08–0.53).

Conclusion

This study found that PBL is an effective teaching method for pharmacy students.
Physical, sexual and overall reported interpersonal violence against adult out-patients with severe mental illness under remission, receiving healthcare at Butabika hospital: A cross-sectional study
Authors: Guma Edgar Innocent , Bangirana Paul , Birungi Caroline , Ocen Patrick , Morawej Zahra , Nakasujja Noeline
Published: December 2024

Interpersonal violence is a significant public health and human rights concern. People living with severe mental illness are especially vulnerable. The Sustainable Development Goals 2030 Agenda aims to end violence. To this end, we gathered information on the prevalence and factors associated with interpersonal violence among one of the most impacted groups: individuals with severe mental illness at Butabika Hospital in Kampala, Uganda. We conducted a cross-sectional study in 2020, including individuals 18 years or older. Data was collected through a socio-demographics questionnaire and nine questions from the modified My Exposure to Community Violence Questionnaire. The assessment evaluated physical or sexual violence experience, frequency, and perpetrator identity. The data was analyzed using STATA version 12 through simple logistic regression to determine the correlation between a single exposure and the outcome of interest, with a significance level of 5%. Among 385 participants, the past year prevalence of overall reported interpersonal violence was about 34%, while physical and sexual reported interpersonal violence were approximately 29% and 11%, respectively. Participants who had perpetrated physical violence had higher odds of experiencing reported interpersonal violence. With increasing age, the odds of experiencing reported interpersonal violence decreased; compared to those aged 18–24 years, those aged 35–44 years had AOR = 0.31 (95% CI: 0.14–0.70, p = 0.005), and those aged 45 years and above had AOR = 0.34 (95% CI: 0.15–0.80, p = 0.013). Reported interpersonal violence was high among the participants. While individuals of older age had lower odds of reporting interpersonal violence, those who had perpetrated physical violence in the past year had higher odds. Screening for interpersonal violence among young patients is recommended. Psycho-education on preventing physical violence should be provided, especially to younger adults. The Ministry of Health should address violence against individuals with mental illness through mass sensitization. A prospective study could investigate risk and protective factors.
Imaging analytical technique to assess gastrointestinal motility in vivo using zebrafish larvae with diabetes mellitus-like traits
Authors: Hui Jessica C. M. , Du Peng , Webb Sarah E. , Liu Julia Y. H. , Ngan Man Piu , Lu Zengbing , Ng Heidi S. H. , Yang Lingqing , Khalid Aleena , Liu Luping , Li Zitong , Deng Yingyi , Cui Dexuan , Rudd John A.
Published: December 2024

In diabetes mellitus (DM), the prevalence of gastrointestinal (GI) complications, including constipation, diarrhoea, gastroparesis, and/or enteropathy, can be up to ~75%. In this study, we compared three zebrafish larvae models of DM and established an analytical protocol for GI motility. Larvae were fed with either a standard diet (SD; control), or one of three diets to induce a DM-like phenotype: excessive feeding of SD food (ED), a high-fat diet (HFD), or exposing SD-fed larvae to 30 mmol/L glucose (SDG). DM was confirmed using a body-mass index, assessment of adipose deposit areas, two glucose assays, and one insulin assay. An analytical technique, whereby GI motility was quantified using pixel differences to track displacement along the centreline of the anterior, middle, and posterior intestine (AI, MI, and PI, respectively), was developed. Our results indicated that clear DM-like traits were observed in the HFD and SGD models, but not the ED model. In the SD controls, the AI showed similar anterograde and retrograde contractions indicating normal GI mixing; the MI exhibited more prominent forward contractions, and the PI showed distinct rectal waves. Compared to the SD, the HFD and SDG models exhibited significantly increased and decreased contraction velocities and could be used as models of diarrhoea and constipation in DM, respectively, while the ED model showed comparatively little change in motility. Together, these data indicate that complex changes in GI motility are associated with diet and therapeutics used to alleviate GI complications in DM should take these into account. Ultimately, the HFD and SDG models can be used to investigate different aspects of GI motility in association to DM. Hence, zebrafish are a useful model for studying GI dysfunctions due to DM and/or DM medication side-effects.
The NF-κB-HE4 axis: A novel regulator of HE4 secretion in ovarian cancer
Authors: Kim Kyukwang , Khazan Negar , McDowell Jamie L. , Snyder Cameron W. A. , Miller John P. , Singh Rakesh K. , Whittum Michelle E. , Turner Rachael , Moore Richard G.
Published: December 2024

Ovarian cancer is the leading cause of death among gynecologic malignancies. Despite recent advancements in targeted therapies such as PARP inhibitors, recurrence is common and frequently resistant to existing therapies. A powerful diagnostic tool, coupled with a comprehensive understanding of its implications, is crucial. HE4, a clinical serum biomarker for ovarian cancer, has shown efficacy in monitoring malignant phenotypes, yet little is known about its biological role and regulatory mechanisms. Our research demonstrates that HE4 expression in ovarian cancer can be regulated by the NF-κB signaling pathway. We found that the activation of NF-κB signaling by tumor necrosis factor (TNF)-α, a cytokine found in ovarian cancer tumors and ascites, enhanced the secretion of HE4 while its inhibition suppressed HE4 levels. Nuclear translocation of the NF-κB component p65 was found to be critical for HE4 expression; induced NF-κB activation through p65 expression or constitutive IKK2 activity elevated HE4 expression, while p65 knockdown had the opposite effect. Furthermore, we observed that NF-κB mediated HE4 expression at the transcriptional level. Our data also suggests that there is a regulatory role for HE4 in the expression of α5-Integrin, a crucial adhesion molecule in ovarian cancer metastasis; HE4 knockdown corresponded with reduced α5-Integrin expression, cell migration and cell adhesion to fibronectin.
Planting date in South Kivu, eastern DR Congo: A real challenge for the sustainable management of Spodoptera frugiperda (Lepidoptera: Noctuidae) by smallholder farmers
Authors: Cokola Marcellin Cuma , Noël Grégoire , Mugumaarhahama Yannick , Caparros Megido Rudy , Bisimwa Espoir B. , Francis Frédéric
Published: December 2024

There is growing research interest in the fall armyworm (FAW) Spodoptera frugiperda, a polyphagous insect that is a major pest of maize crops worldwide. We investigated the relationship between planting date of maize and FAW infestation in South Kivu, eastern Democratic Republic of Congo, in two sampling seasons (September to October 2020 and February to March 2021). Five planting dates were considered for 45 fields in each season. The incidence, severity of attack and larval density of FAW were assessed at the 8-leaf stage (V8) of maize development in monoculture and intercropping systems. Planting period, classified as late or early, had a strong influence on FAW larval density, incidence and severity. The results showed that the late planting period (mainly on 30 October in season-1 and 30 March in season-2) had the highest larval density, incidence and severity of attack compared to the early planting period (15 September in season-1 and 01 Mars in season-2). During the season-1, five larval stages were found in the same field, whereas all larval stages were present in season-2, regardless of planting period. High densities of L4, L5 and L6 larvae were much more associated with late planting and incidence appeared to be highest when these larvae were present. The presence of L2 and L3 larval stages was observed in maize cropping systems intercropped with soybean and peanuts, while maize in monoculture and intercropped with cassava and beans was colonized by L4, L5 and L6 larvae. This study highlights the existence of different maize planting dates in South Kivu and demonstrates that late plantings have significant FAW infestations compared to early plantings. It provides a basis for developing climate-smart integrated pest management.
Oral microbiome test as an alternative diagnostic tool for gastric alterations: A prospective, bicentric cross-sectional study
Authors: Martins Fernanda Prata , Andrade-Silva Jessica , Teixeira Bianca Luise , Ferrari Angelo , Christoff Ana Paula , Cruz Giuliano Netto Flores , Paladino Fernanda Vieira , de Oliveira Luiz Felipe Valter , Hernandes Camila
Published: December 2024

The human microbiome plays a pivotal role in influencing various physiological processes and maintaining overall well-being, including the gastric system. Current diagnostic tests for gastric diseases often involve invasive procedures, sampling limitations, and medication effects, leading to potential diagnostic errors and discomfort to patients. Considering the connection between oral and gastric microbiomes, this cross-sectional study aimed to assess the diagnostic potential of the oral bacterial profile in patients undergoing upper digestive endoscopy. Oral samples from 266 participants across two Brazilian sites (Belterra and Sao Paulo) were sequenced and subjected to bioinformatic analysis to identify microbiome composition across endoscopy outcome groups, exploring alpha and beta-diversity, richness, and differential abundance and prevalence. Prevotella, Haemophilus, Fusobacterium, Neisseria, and Streptococcus were the most abundant genera observed. No significant associations were found between alpha diversity profiles and endoscopy outcomes; beta diversity analyses similarly showed no correlations. Overall, the study did not establish the oral microbiome as a reliable marker for gastric health, underscoring the necessity for broader studies in the development of non-invasive diagnostic tests.
Factors associated with predicting knee pain using knee X-ray and personal factors: A multivariate logistic regression and XGBoost model analysis from the Nationwide Korean Database (KNHANES)
Authors: Kim Taewook
Published: December 2024

With increasing life expectancy, knee pain has become more prevalent, highlighting the need for early prediction. Although X-rays are commonly used for diagnosis, knee pain and X-ray findings do not always match. This study aims to identify factors contributing to knee pain in individuals with both normal and abnormal knee X-ray results to bridge the gap between X-ray findings and knee pain. Data from the fifth Korea National Health and Nutrition Examination Survey (KNHANES), collected from 2010 to 2012, including data from 5,191 participants, were analyzed. The focus was on epidemiological characteristics, medical histories, knee pain, and X-ray grades. Multivariate logistic regression and extreme gradient boosting (XGBoost) models were used to predict knee pain in individuals with normal and abnormal knee X-rays, categorized by Kellgren-Lawrence grades. For normal X-rays, the logistic regression model identified aging, being female, higher BMI, lower fat percentage, osteoporosis, depression, and rural living as factors associated with knee pain. The XGBoost model highlighted BMI, age, and sex as key predictors, with a feature importance >0.1. For abnormal X-rays, logistic regression indicated that aging, being female, higher BMI, osteoporosis, depression, and rural living were associated with knee pain. The XGBoost model highlighted age, BMI, sex, and osteoporosis as key predictors, with a feature importance >0.1. Aging and being female were associated with knee pain due to hormonal changes in women, as well as cartilage and bone deterioration. Lower fat percentage was significantly associated with increased pain, which might be attributable to higher activity levels. Higher BMI and osteoporosis were significantly associated with knee pain, possibly due to increased stress and reduced resistance on knee structures, respectively. Depression was identified as a key predictor of knee pain in patients with normal X-rays, potentially attributable to psychosomatic factors. The study’s limitations include its cross-sectional nature, which does not allow for the establishment of causal relationships, the lack of detailed medical history such as trauma history, and recall bias due to self-reported questionnaires. Future research should address these limitations to support our hypothesis.
Can farmers’ digital literacy improve income? Empirical evidence from China
Authors: Liu Tian , Liao Lan
Published: December 2024

This paper explore the impacts and mechanisms of digital literacy of farm households on income. The baseline regression of the impact of digital literacy of farm households on household income uses a fixed effects regression model, and the 2SLS regression model is used to address the endogeneity problem present in the model. The findings reveal that improving digital literacy among rural households significantly increases their family income, a result that remains robust even after considering endogeneity issues. Further examination of the mechanisms shows that enhancing digital literacy among rural households significantly improves their information acquisition capabilities and cognitive skills. It also deepens financial services, boosting the usage and engagement of rural households in digital financial activities, thereby enhancing family income levels. Facilitating rural residents’ access to digital skills and tools to ride the digital economic wave, ensuring fair access, and achieving sustainable family income are of paramount significance for rural revitalization. It is also a crucial step in bridging the digital divide and promoting shared prosperity.
Fashion in Altermodern China, Feng Jie (2022)
Authors: Wu Juanjuan
Published: December 2024

Review of: Fashion in Altermodern China, Feng Jie (2022)

London: Bloomsbury, 168 pp.,

ISBN 978-1-35020-006-7, h/bk, $90
Memories of Dress: Recollections of Material Identities, Alison Slater, Susan Atkin and Elizabeth Kealy-Morris (eds) (2023)
Authors: Amit Tal Granovsky
Published: December 2024

Review of: Memories of Dress: Recollections of Material Identities, Alison Slater, Susan Atkin and Elizabeth Kealy-Morris (eds) (2023)

London: Bloomsbury Visual Arts, 258 pp.,

ISBN 978-1-35015-379-0, h/bk, £85.00
Rethinking Work-Family Balance in Italy: Case Studies and Innovative Strategies
Authors: Crespi Isabella , Palermo Melanie Sara
Published: December 2024

Promoting work–life balance is nowadays a priority of public policies: it is considered in global recommendations (the SDGs by the UN) and national policies (in Italy, for example, it is part of the National Plan of Recovery and Resilience). However, the public measures that are implemented are insufficient to guarantee employees a good work–life balance, and organisations have understood that planning through ‘corporate family responsibility’ schemes can lead to several economic benefits. Thus, considering the needs of individuals and the challenges imposed by society and by the COVID-19 pandemic, the article constitutes an exploratory study that presents two case studies of organisational welfare in Italy to reflect upon the efficacy of corporate family responsibility activities. The research considers companies as places made up of human relations among social actors that can contribute to the formation of a society based on people and the value they can create.
Administration of Local Economic Development:

Case Study of the Zamboanga Peninsula

Region, Philippines
Authors: Moreno Frede , Sulasula Josephine
Published: December 2024

This study examines the administration of Local Economic Development (LED) in the Zamboanga Peninsula region of the Philippines, analyzing the role of local government units (LGUs), private sector involvement, and community participation in fostering sustainable economic growth. Despite the region's rich natural resources and strategic location, it faces persistent socio-economic challenges, including high poverty rates, inadequate infrastructure, and political instability. This research investigates the effectiveness of LED initiatives, focusing on the implementation of policies, the promotion of public-private partnerships (PPPs), and the capacity of LGUs to manage and facilitate local development projects. Utilizing a mixed-methods approach, the study combines qualitative interviews with local stakeholders—government officials, business leaders, and community members—alongside quantitative data on economic performance and social indicators. The findings reveal both successes and challenges in local governance, highlighting the importance of inclusive planning, capacity-building, and addressing socio-economic disparities. Key obstacles include weak institutional coordination, limited resources, and insufficient infrastructure investment. The study offers policy recommendations to strengthen governance frameworks, enhance private sector engagement, and promote community-driven development. By focusing on the Zamboanga Peninsula, this research contributes to broader discussions on effective LED administration in decentralized settings, providing insights for improving local economic development practices in similar regions globally.
Validation procedures for assessing the properties of anti-vandal materials for applications in public transport vehicles
Authors: Irzmańska Emilia , Mizera Kamila , Sałasińska Kamila
Published: December 2024

Validation of methods for assessing the properties of anti-vandal hybrid composites modified with inorganic and plant fillers, with reduced flammability and smoke emission and high resistance to vandalism, intended for use in public transport, was carried out. Four standardized procedures, intended for testing personal protective equipment (protection of upper and lower limbs), including impact, and cut resistance and flame resistance, were modified. Since the tested materials were to be used in applications beyond the scope of the original test procedures, each method required re-validation. In this work, systematic and random errors of measurements that could affect the reliability and validity of the methods were identified. Therefore, individual uncertainty components, which characterize the dispersion of values assigned to the measured quantity at a given probability level, were precisely determined and then combined into uncertainty budgets for individual methods. After the validation, the methods can be successfully used to assess anti-vandal composite materials in the context of resistance to vandalism in public transport.
Klimaanpassung als integratives Handlungsfeld
Authors: Hoffmann Esther , Johnson Daniel
Published: December 2024

Einführung in das Schwerpunktthema
Multifunktionale Grünflächen als Kernbausteine kommunaler Klimaanpassung
Authors: Möllney Tobias
Published: December 2024

Die Auswirkungen des Klimawandels werden insbesondere in urbanen Räumen zunehmend spürbar. Daher rückt eine klimaangepasste Stadtentwicklung immer mehr in den Fokus, zuletzt durch das erste bundesweite Klimaanpassungsgesetz. Welchen Beitrag können multifunktional gestaltete Grünflächen zur kommunalen Klimaanpassung leisten?
Freiwillige Nachhaltigkeitsberichterstattung für KMU
Authors: Schulze Mike , Weber Torsten , Oerder Luis
Published: December 2024

Ein neuer Standard für Nachhaltigkeitsberichterstattung soll Kleinstunternehmen eine freiwillige und standardisierte Berichterstattung ermöglichen. Dieser Ansatz erleichtert es kleinen und mittleren Unternehmen, ihre nachhaltigen Praktiken transparent zu machen.
Filling gaps in the distribution of the Guianan broad-nosed bat (Platyrrhinus guianensis): an extension in distribution beyond the Guiana Shield
Authors: Ferreira Gilmax Gonçalves , Trevelin Leonardo C. , Tavares Valéria da C. , de Castro Isai J. , Nagamachi Cleusa Y. , Rossi Rogério V. , Pieczarka Julio C. , Melo Benathar Thayse C.
Published: December 2024

The distribution of Platyrrhinus guianensis, a species originally considered endemic to the Guiana subregion, has recently been extended to a southernmost Brazilian Amazon point, yet included within the Guiana Shield. Based on comprehensive revisionary work, we extend this species occurrence eastwards and southwards, encompassing 11 localities, including Eastern Amazonia forests. These records correspond to primary and secondary floodplain forest habitats in the Brazilian states of Amapá, Maranhão, Mato Grosso, and Pará.
Gerechter Friede – eine pfingstliche Perspektive
Authors: Wenk Matthias
Published: December 2024

Als Beitrag zu einem gerechten Frieden stehen den Pfingstkirchen zwei Ressourcen zur Verfügung, die sie jedoch unterschiedlich nutzen: (1) Apg 2, ihr identitätsstiftendes Narrativ, mit den „vielen Zungen“ als linguistisches Symbol des Friedens, und (2) ihre Geschichte, die ihre Anfänge in einem von Ungerechtigkeit und Gewalt geprägten Umfeld nahm, in welchem die Opfer der Gewalt ihren Feinden die versöhnende Hand entgegenstreckten.
NRXN1-related disorders, attempt to better define clinical assessment
Authors: Pavone Piero , Pappalardo Xena Giada , Parano Claudia , Falsaperla Raffaele , Corsello Antonio , Parano Enrico , Polizzi Agata , Ruggieri Martino
Published: December 2024

Background

NRXN1-related disorders are uncommonly reported. The clinical features of the disorders are wide and heterogeneous mainly consisting of undistinctive facial dysmorphism, mild to severe intellectual and speech delay, epileptic seizures, and motor dysfunction. Defects in NRXN1 gene have been identified in cases diagnosed as Pitt-Hopkins-like-syndrome 2 (PTHLS2; OMIM#614325).

Methods

Literature review of NRXN1-related disorders was conducted and main clinical features of individuals affected by these disorders were analyzed. In addition, clinical features of individuals labelled with PTHSL2 diagnosis were reported. A comparison between international consensus diagnostic criteria for Pitt-Hopkins syndrome (PTHS) and twins presenting with NRXN1-related disorder and followed by this institution were also presented.

Results

Our data confirmed that NRXN1-related disorders mainly manifest with undistinctive dysmorphic features and neurological involvement consisting of more or less severe developmental delay/intellectual disability, autistic spectrum disorder, and epilepsy. Relationship between PTHSL2 and NRXN1 remains to be established.

Conclusions

Our present analysis denoted a heterogeneous and unspecific clinical framework of the NRXN1-related disorders mainly affecting the nervous system for which the clinical diagnosis remains inconclusive without the support of genetic analysis. Further contributions are necessary to better clarify the clinical assessment of PTHSL2.
Genetic diagnosis of the Ehlers-Danlos syndromes
Authors: Zschocke Johannes , Demirdas Serwet , van Dijk Fleur S.
Published: December 2024

The Ehlers-Danlos syndromes (EDS) represent a group of genetically diverse disorders characterized by the variable combination of joint hypermobility, hyperextensibility of the skin, and connective tissue fragility affecting the skin and other organs. Based on clinical features, 13 different types of EDS have been delineated, 12 of which represent monogenic conditions caused by pathogenic variants in 21 confirmed genes. Pathogenesis is related to disturbances of collagen formation and/or stability. No monogenic cause has been identified for hypermobile EDS (hEDS), a more common EDS type, which is unlikely to represent a single gene disorder in the majority of affected individuals and at present cannot be diagnosed by genetic investigations. Here we summarize the clinical features and the molecular bases of the monogenic EDS types, highlight diagnostic challenges, and provide guidance for the molecular work-up of affected individuals. In general, genetic tests are indicated if clinical features suggest a monogenic EDS type but are usually unrewarding for other cases of hypermobility.
Non-genetic diagnostic investigations in monogenic Ehlers-Danlos syndromes
Authors: Dijk Fleur S. van , Angwin Chloe , Ghali Neeti , Zschocke Johannes , Wagner Bart
Published: December 2024

With increased application of Next Generation Sequencing (NGS) in the diagnosis of monogenic Ehlers-Danlos syndromes, there is an increased probability to identify variants of unknown significance. Additionally, in some cases no genetic alteration may be identified whilst there is a strong clinical suspicion on a monogenic EDS type. The diagnostic value of non-genetic investigations, which prior to NGS were quite commonly used to support the clinical diagnosis of monogenic EDS types, is explored. In addition, new structural/functional investigations that could deliver evidence towards pathogenicity are discussed. It appears that certain functional and/or structural investigations used frequently in the past can remain helpful and can provide additional evidence that may confirm a clinical diagnosis of a monogenic EDS type. However, there is a need for the development of novel structural/functional studies for monogenic types of EDS. The level of evidence of such studies for application in the established diagnostic DNA variant classification criteria remains to be determined.
Measuring high-efficiency perfect composite vortex beams with reflective metasurfaces in microwave band
Authors: Hong Jing , Ni Mengyi , Zhang Zhengping , Hu Zheng-Da , Wang Jicheng , Shen Xiaopeng , Wang Xiong , Li Mengmeng , Khakhomov Sergei
Published: December 2024

Optical vortex beams carrying orbit angular momentum have attracted significant attention recently. Perfect vortex beams, characterized by their topological charge-independent intensity profile, have important applications in enhancing communication capacity and optimizing particle manipulation. In this paper, metal-insulator-metal copper-coin type reflective metasurfaces are proposed to generate perfect composite vortex beams in X-band. We introduce the qualified equivalent circuit model based on the theory of transmission line to design the meta-atom of the structure. The experiments are performed to measure the far-field and near-field perfect composite vortex beams and evaluate their orbital angular momentum purity at different frequencies. The experimental results agree well with the theoretical predictions. This work provides new ideas and methods for generating high-quality metasurface-based perfect composite vortex beams in the microwave region, paving an ideal path for microwave communication systems, optical manipulation and radar detection.
Influence of composite material laying parameters on the load-carrying capacity of type IV hydrogen storage vessel
Authors: Zhang Qian , Jiang Wenchun , Yan Jiupeng , Bai Jiangkun , Fan Hui , Wang Bingying
Published: December 2024

The composite material laying parameters are important factors affecting the carrying capacity and quality of the type Ⅳ hydrogen storage vessel. In this article, the composite laying scheme is designed and analyzed by the finite element method. Through 100 groups of laying schemes, the influence laws of circumferential winding layers, spiral winding layers, spiral winding angle, and laying sequence are summarized. The results show that, when the number of spiral winding layers and the number of circumferential winding layers exceed 35 and 25 respectively, the bearing capacity of the hydrogen storage vessel cannot be significantly improved with the increase of the layer number. With the increase in the spiral winding angles, the maximum S11 decreases first and then increases, while the maximum S22 stabilizes first and then increases. But, for different numbers of spiral layers, the turning point of stress rise is different, and the best winding angle is between 55° and 65°. It is found that performing circumferential winding first and then spiral winding is the best winding sequence.
The promotive role of reticulocalbin 3 (RCN3) in the pathogenesis of keloid via TGFβ1/Smad2/Smad7 signaling pathway in vitro
Authors: Wang HongYu , Zhang Zhen , Mi Jie , Liu ZhaoJun , Liu ZhenBao , Wu Haiyan
Published: December 2024

Objectives

Keloids, characterized by an excessive accumulation of fibrous tissue, remain a significant dermatological challenge. This study elucidates the role of Reticulocalbin 3 (RCN3) in modulating keloid fibroblasts (KFs) in vitro.

Methods

The RCN3 expression levels in human KFs and normal dermal fibroblast cells were examined using RT-qPCR and Western blot methods. RCN3 expression was knocked down in keloid fibroblasts after cells were transfected with shRNA targeting RCN3. On the other hand, recombinant RCN3 was added to treat the cells. RT-qPCR, Western blot, flow cytometry, CCK8 assays, and wound healing assays were performed to analyze the fibrotic markers (collagen I, III, MMP2, α-SMA) and TGFβ1/Smad2/6/7 pathway, apoptosis, proliferation and migration.

Results

RCN3 was upregulated in KFs. Its knockdown reduced fibrotic marker expression (collagen I, III, MMP2, α-SMA), cell proliferation, and migration, while increasing apoptosis. Conversely, recombinant RCN3 treatment enhanced the fibrotic responses. Changes in TGFβ1/Smad2 pathway, especially in Smad2 phosphorylation and Smad7, were evident following RCN3 modulation.

Conclusions

The study reveals RCN3 as a regulator in keloid pathology, affecting fibrosis, cellular behavior through TGFβ1/Smad2/Smad7 signaling.
Zur Schreibung türkischer Familiennamen in deutschen Zeitungstexten
Authors: Zimmer Christian
Published: December 2024

German and Turkish differ (slightly) in terms of their grapheme inventories. This leads to variation in the spelling of many Turkish names in German: Either the Turkish letters are used (e. g. the lowercase letters ç, ğ, ı, ş) or integrated alternatives (c, g, i, and s). This article analyses how common Turkish surnames are written in German-language newspaper texts (e. g. Gündoğan vs. Gündogan). It is shown that the use of Turkish letters tends to increase, that ç is used much more frequently than the other letters, and that there are significant differences between the newspapers analysed. The change in favour of the non-integrated variants is then explained (on the basis of metalinguistic comments) with their indexical potential: the non-integrated spelling is typically interpreted as correct and respectful and serves to indicate linguistic knowledge.
Referenzketten und stilistische Variation in der Sekundarstufe
Authors: Bryant Doreen
Published: December 2024

If an entity is referred to multiple times in a text, a reference chain is created. This chain is considered neutral or unmarked when it is structured as follows: eine Frau – die Frau – sie – sie – sie … (‘a woman – the woman – she – she – she…’) (Thurmair 2003). Most studies on referential coherence (including those related to language acquisition) focus on animate entities in texts.

For older school pupils to handle different types of texts (e. g. reports, descriptions, explanations) adequately, the question arises as to how references are made to inanimate objects in texts and whether simple possibilities of stylistic variation are used.

In this experimental study with secondary-school pupils (Grades 5 and 8) and university students, we elicited chains of references to inanimate entities (eine Tasche – die Tasche – sie, ‘a bag – the bag – it’) and investigated the unmarked structuring of these references (indefinite NP – definite NP – personal pronoun) and the degree of precision in the introductory nominal phrase in terms of composition and/or attributes (e. g. eine Handtasche, eine gelbe Tasche, eine gelbe Handtasche, ‘a handbag, a yellow bag, a yellow handbag’). We also explored whether potential for variation was exploited through partial recurrence (e. g. eine Handtasche – die Tasche, ‘a handbag – the bag’).

Although all three groups preferred using neutral reference chains, there were clear differences in the degree of preference between the two groups of pupils, on the one hand, and the students, on the other. The groups also differed regarding their use of precision and the extent to which they varied references through partial recurrence. In addition, deviations in agreement between a pronoun and its previous mention were observed in some pupils with German as a second language who followed the semantic strategy of referring to inanimate entities using the neutral pronoun es (independent of the grammatical gender) (e. g. eine gelbe Tasche – die Tasche – *es). Another surprising finding can be seen in the student group. In an effort to express themselves diversely and eloquently, the students varied the personal and demonstrative pronouns within the reference chains without considering that demonstrative pronouns fulfil specific grammatical functions in texts (Diessel, 1999; Bosch & Umbach, 2007) and that incorrect use confuses the reader, potentially leading to misinterpretation.

As analyses of textbooks have shown that referential coherence is largely neglected in German instruction (Averintseva-Klisch, Bryant & Peschel, 2019), the findings are hardly surprising. They demonstrate once again that more attention needs to be paid to this phenomenon in teacher training and in work on texts in schools.
A Experiência do PIBID/História na E.M.E.F. profª Maria Nadir Filgueira Valente
Authors: Américo Magalhães Élita Paloma
Published: December 2024

Este artigo tem por objetivo relatar a respeito das experiências didático-pedagógicas do PIBID/História na turma de 6° ano “B”, da E.M.E.F. Profª Maria Nadir Filgueira Valente, situada na cidade de Cametá/PA. Precisamente, apresentam-se aqui, as ações desenvolvidas com o Conteúdo Curricular “Introdução ao estudo de História” e “A vida humana no Paleolítico e Neolítico”, com ênfase ao uso diferenciado da utilização do seminário, enquanto estratégia metodológica. Busca-se, com isso, contribuir para o debate pedagógico e epistemológico que possibilite pensar novas formas de interação e de ensino-aprendizagem, capazes de fomentar a curiosidade, o interesse e a criticidade do aluno.Palavras-chave: Ensino de História; Sala de Aula; Metodologia de Ensino. AbstractThis article aims to report on the didactic-pedagogical experiences of PIBID/História that took place in the 6th grade class “B”, from E.M.E.F. Profª Maria Nadir Filgueira Valente, located in the city of Cametá/PA. Precisely, it presents here the actions developed with the Curricular Content “Introduction to the study of History” and “Human life in the Paleolithic and Neolithic”, with emphasis on the differentiated use of the usage of the seminar as a methodological strategy. This article seeks to contribute to the pedagogical and epistemological debate that makes it possible to think of new forms of interaction and of teaching-learning capable of fostering the student's curiosity, interest and criticality.Keywords: History teaching; Classroom; Teaching Methodology.
“Impedido de entrar porque falava português”: Relações Interétnicas e Espaços de Sociabilidades em Mallet-PR (1930-1940)
Authors: Ferrando Loiana Maiara Zviegicoski
Published: December 2024

A finalidade deste trabalho é refletir sobre as relações interétnicas estabelecidas em espaços de sociabilidades de Mallet-PR, tendo como fonte de análise inquéritos policiais e processos criminais. Nosso recorte temporal compreende o ano de 1930 até 1940, devido à grande incidência de ocorrências criminais envolvendo imigrantes. Esses, ao se instalarem no território malletense, ocasionaram sociabilidades informais e formais, entre si e com os demais, seja por meio das associações ou em ambientes públicos, com interesses e objetivos variados. Entretanto, em determinados momentos, esses acontecimentos também resultaram em conflitos, ressaltando questões que permeavam os grupos étnicos. Palavras-chave: Mallet; Sociabilidades; Imigração; Grupos étnicos. AbstractThe purpose of this article is to reflect on the interethnic relations established in spaces of sociability in Mallet-PR, having as a source of analysis police investigations and criminal cases. Our time frame covers the years 1930 to 1940, due to the high incidence of criminal incidents involving immigrants. These immigrants, when they settled in Mallet, led to informal and formal sociability, among themselves and with others, either through associations or in public environments, with varied interests and objectives. However, at certain times, these events also resulted in conflicts, highlighting issues that permeated ethnic groups.Keywords: Mallet; Sociability; Immigration; Ethnic groups.
Sociabilidade e lazer no cotidiano dos populares da Comarca de Bragança-PA (1910-1920)
Authors: Miranda Filipe de Sousa
Published: December 2024

A partir das narrativas contidas nos Autos crimes de ferimentos leves produzidos pela Comarca de Bragança-PA entre os anos de 1910 e 1920, o presente artigo objetiva trazer à tona os momentos de sociabilidade e lazer que compunham o cotidiano dos segmentos populares, que habitavam as diversas localidades sob as quais se estendia a jurisdição desta unidade judiciária. A abordagem proposta é de caráter qualitativa. Os dados foram reunidos mediante pesquisa documental realizada no acervo arquivístico histórico da Comarca de Bragança-PA, que mapeou quatro processos criminais que atendiam aos propósitos da pesquisa.  O texto desvela momentos de sociabilidade e lazer, que são reveladores das vivências dos populares em espaços, como botequins, tavernas, igrejas, ou simplesmente, a residência de algum conhecido.Palavras-chave: Processos criminais; Comarca de Bragança-PA; Sociabilidade; Lazer; Cotidiano. AbstractBased on the narratives contained in the proceedings, minor injury crimes committed by the Comarca de Bragança-PA between the years 1910 and 1920, this article aims to bring to light the moments of sociability and leisure that made up the daily life of the popular segments, which inhabited the different locations under the jurisdiction of this unit. The proposed approach is of qualitative nature. The data were gathered through documentary research carried out in the historical archive of the Comarca de Bragança-PA, which mapped four criminal cases that served the purposes of the research. The text unveils moments of sociability and leisure, which reveal the experiences of the people in spaces such as taverns, bars, churches, or, simply, the residence of an acquaintance.Keywords: Criminal proceedings; District of Bragança-PA; Sociability; Leisure; Daily life.
Relações de gênero e direitos na história da hotelaria pelotense: estudo de processos trabalhistas envolvendo mulheres entre 1940 e 1960
Authors: Duarte Renata
Published: December 2024

O presente estudo tem como objetivo analisar documentalmente 15 processos trabalhistas da Justiça do Trabalho de Pelotas entre 1940 e a primeira metade da década de 1960, relacionados à hotelaria, que envolvem mulheres nas posições de “reclamantes” ou de “reclamadas”. A análise documental, segundo Cellard (2012), tem seu início com uma análise preliminar em cinco dimensões antes de “fornecer uma interpretação coerente, tendo em conta a temática ou o questionamento inicial” (CELLARD, 2012, p. 303). Nesse sentido, verificou-se nos processos trabalhistas a existência de salários mais baixos para as mulheres e, igualmente, que as principais profissões apresentadas possuem relação com os papéis desempenhados no ambiente familiar: camareira e cozinheira. Dessa forma, é notável a necessidade de evidenciar a atuação das mulheres enquanto força de trabalho na hotelaria.Palavras-chave: História da Hotelaria; Trabalho; Mulheres; Processos Trabalhistas; Pelotas. AbstractThis study aims to analyze, documentally, 15 labor lawsuits from the Justiça do Trabalho de Pelotas [Pelotas Labor Court] between 1940 and the first half of the 1960s. The lawsuits are related to hospitality and involve women in the positions of “defendant” or “complainants”. Documentary analysis, according to Cellard (2012), begins with a preliminary analysis in five dimensions before “providing a coherent interpretation, taking into account the theme or the initial questioning” (CELLARD, 2012, p. 303). With this in mind, it was verified in the labor processes the existence of lower salariess for women and, equally, that the main professions shown are related to the roles played in the family environment: maid and cook. Thus, the need to highlight the role of women as a work force in the hotel industry is notable.Keywords: Hotel History; Labor; Women; Labor Lawsuits; Pelotas.
A aprovação da lei do divórcio de 1977: uma revisão bibliográfica acerca do tema e as revistas Manchete e Veja como fontes para a pesquisa histórica
Authors: Quissini Lauren Cavichioli
Published: December 2024

Este artigo traz como objetivo principal uma revisão bibliográfica de estudos acerca da temática do divórcio no Brasil, evidenciando brevemente sobre os debates que ocorreram no período da década de 1970 em torno da questão. Junto disso, serão apresentados alguns pressupostos teóricos sobre a utilização da imprensa como fonte histórica, trazendo os exemplos das revistas Manchete (1952-2000) e Veja (1968-presente). Metodologicamente, trata-se de uma pesquisa de abordagem bibliográfica qualitativa orientada, principalmente, pelos escritos de Moura (2010), De Senna (2006) e De Fáveri (2007). Os resultados indicam que a discussão e a ampliação de estudos sobre a aprovação da lei do divórcio no Brasil, mostram-se necessários para a compreensão de valores, questionamentos, permanências e mudanças assentes no meio social brasileiro. Palavras-chave: Divórcio; Igreja Católica; História e Imprensa. AbstractThis article has as main objective a bibliographic review of studies about the theme of divorce in Brazil, briefly highlighting the debates that occurred in the period of the 1970s around the issue. Alongside this, some theoretical assumptions about the use of the press as a historical source will be presented, bringing examples from the magazines Manchete (1952-2000) and Veja (1968-present). Methodologically, this is a qualitative bibliographic research, guided mainly by the writings of Moura (2010), De Senna (2006) and De Fáveri (2007). The results indicate that the discussion and expansion of studies on the approval of the divorce law in Brazil are necessary for the understanding of values, questions, permanence and changes based on the Brazilian social environment.Keywords: Divorce; Catholic Church; History and Press.