bluuebunny/crossref_metadata_2025 huggingface dataset:
Accumulation of Natural Gas with a Prospective Material Based
on Graphene Aerogel
Authors: Memetova A. E. , Neskoromnaya E. A. , Zelenin A. D. , Babkin A. V. , Memetov N. R. , Gerasimova A. V.
Published: December 2021

The assessment of the possibility of effective use of graphene aerogels for the adsorption storage and transportation of methane is given. For the study,
an aerogel based on reduced graphene oxide was synthesized using supercritical methods for processing a hydrogel in an isopropyl alcohol medium.
A narrow distribution of micropores with a maximum at 0.8 nm, a narrow distribution of mesopores with a maximum at about 4.5 and 6.5 nm were revealed.
The obtained graphene aerogel (GA) was used to study the adsorption of methane at pressures up to 10 MPa and temperatures of 298, 303, 313 K. The maximum gravimetric absorption of methane reaches 0.86 g/g (37 cm3 (STP)/cm3) and 2.6 g/g (109 m3 (STP)/m3) at corresponding pressures of 35 and 100 bar and a temperature
of 298 K, which is the highest recorded value for porous carbon previously reported.
Water Management in Regional Sustainable Development
Authors: Balamutova A. A. , Popov N. S.
Published: December 2021

In recent decades, human activities have increasingly influenced hydrological systems. The concept of sustainable development of water infrastructures in the constituent entities of the Russian Federation is an important basis for their use in the interests of present and future generations of people. The modern features of water management are considered, an example of water supply in the city of Tambov is given,
a conclusion is made about the need to create a problem-oriented information and analytical system for support and decision-making in the face of uncertainties of future socio-economic and environmental challenges.
Implementation of the Regional Socio-Economic Policy
in Conditions of Contemporary Threats and Challenges
Authors: Bondarskaya T. A.
Published: December 2021

The analysis of the socio-economic situation in the Tambov region is carried out. The assessment of the effectiveness of the implementation of socio-economic policy in the context of modern threats and challenges is presented. Taking into account the fact that in all constituent entities of the Russian Federation the situation with the spread of coronavirus infection proceeds differently, regional authorities of each constituent entity, in addition to federal measures, began to develop and apply their own measures of social support for citizens.
Regional Event-Marketing: Multi-Criteria Evaluation
of the Effectiveness of the Events in Tambov
Authors: Tolstyakov R. R. , Petrenko A. S. , Gorbunov I. N.
Published: December 2021

The article considers the problems of assessing
the effectiveness of event marketing on the example of regional events held in the city of Tambov. The results of a survey of residents who participated in such events are presented. Criteria are presented that increase the satisfaction of citizens and, as a consequence, affect the recognition of both the event itself at the regional level and the commercial brands involved in organizing and conducting the event. Tracking of brands’ health has been created. Recommendations
for improving the communication efficiency of event marketing are given.
Research into Physical and Technical Training
of Players of the Derzhava Basketball Club
at Derzhavin Tambov State University
Authors: Bogdanov M. Yu. , Boldyreva V. B. , Shibkova V. P.
Published: December 2021

The physical and technical training of the players of the Derzhava basketball club was tested in order to correctly build the training process, in which team players can withstand not only training loads, but also successfully perform in competitions held between universities and in the region.
[RETRACTED] Label X Muscle Reviews : (Muscle Formula) Should You Buy? v1
Authors: not provided visage
Published: December 2021

[RETRACTED]

To safely boost levels of testosterone, this recipe uses Black Label X’s natural ingredients. Without knowing it, many men have low testosterone levels, a condition that affects effective performance.
[RETRACTED] Label X Muscle : Do They Work? Is It Worth the Money? (Legit or Scam) v1
Authors: not provided labelx
Published: December 2021

[RETRACTED]

Black Label X is a male health supplement that has been formulated with scientifically researched ingredients. It is marketed as an incredible testosterone booster that empowers men to perform better and positively impacts the sex life of men.
Candida tropicalis filamentation assay with fluconazole v1
Authors: de Microbiología Mr JORGE ENRIQUE PEREZ CARDENAS Laboratorio , Hernandez Sebastian
Published: December 2021

This protocol was used to obtain enough quantity of RNA of a nonsusceptible strain of Candida tropicalis, with the goal to do a transcriptomic analysis to demonstrate the degree of differential expression of genes under filamentation and non-filamentation conditions and against a non-filamenting strain, susceptible to fluconazole (Candida tropicalis ATCC750)
Современные подходы к изучению и применению цифровой гуманитаристики в высшей школе
Authors:   Санкт-Петербургский государственный университет, Гаевская Е.Г. , Кононова О.В. ,   Университет ИТМО,   Центр исследований цифрового общества, Прокудин Д.Е. ,   Санкт-Петербургский государственный университет,   Университет ИТМО,   Центр исследований цифрового общества
Published: December 2021

В современном обществе цифровые гуманитарные науки являются методологической основой и инструментом проведения научных исследований. При этом они активно изучаются и применяются в образовании, где рассматриваются с точки зрения содержания образования, методики преподавания и исследовательских практик. Рассматривая активное использование цифровых технологий в образовании как закономерный этап в развитии гуманитаристики, в статье обосновывается необходимость их теоретического осмыслении на основе накопления эмпирических данных. Приводятся некоторые выводы на основе анализа результатов изучения и применения проектного метода, а также комплексного подхода к поиску, экспликации и анализу контекстного знания в Санкт-Петербургском государственном университете и Университете ИТМО.
Out-Group Trust of the Russians in Multicultural Regions of Russia: the Role of Values and Intercultural Contacts
Authors: Galyapina V.N.
Published: December 2021

Objectives. The purpose of this study is to identify the relationship of values and intercultural contacts with intergroup trust among the Russian ethnic minority in two multicultural regions of Russia — the Republic of North Ossetia-Alania (RNO-A), the Kabardino-Balkarian Republic (KBR).
Background. The study of out-group trust is important for multicultural societies. Out-trust contributes to the harmonization of intercultural relations, overcoming unstable social interactions and leads to important public benefits, including personal and social well-being. However, in Russia, trust was studied among the ethnic majority and in the context of acculturation problems.
Study design. We conducted a socio-psychological survey. Data collection took place in towns and villages of North Ossetia-A and KBR, where the Russians live compactly. We used the “snowball” method. Respondents received blank questionnaires, completed them and returned them to the researcher.
Participants. The sample included 593 Russian respondents. In RSO-A, the sample included 291 re¬spondents (29% of men, average age M=44,6); in KBR the sample included 302 respondents (36% of men, average age M=42,7).
Measurements. We used Personal Values Questionnaire — Revised (Schwartz), the Yamagishi scale of trust, the scale of intercultural friendship contacts from the Mutual Intercultural Relations in Plural Societies project (MIRIPS).
Results. The results showed that in RNO-A, Openness to change values, Conservation values were positively associated, and Self-Enhancement values were negatively related to out-group trust through intercultural contacts only. Intensive intercultural contacts of Russians also moderated the positive relationship between Openness to change values and out-group trust. In KBR, Self-Enhancement values had direct and indirect (through intercultural contacts) negative effects on out-group trust only. Intercultural contacts also moderated the negative relationship between Self-Enhancement values and out-group trust.
Conclusions. In general, the results showed that the characteristics of the sociocultural context determine the significance of different values for out-group trust. In the situation of favorable intercultural relations and in “the close” religious context (RNO-A), if the Russians interact intensively with the dominant ethnic group representatives, then their values focused on the self-direction thought and action, openness to the world increase out-group trust. In “the distant” religious context in the situation of interethnic tension (KBR), if the Russians interact intensively with dominant ethnic groups representatives, then their values of achievement, power, “preserving their own face” reduce out-group trust.
Practice with Homeless Persons: the Prospect of the “Invisible” Personality Return
Authors: Vitko J.S. , Lebedeva A.A.
Published: December 2021

Objective. The article analyzes the practices of homeless assistance programs and the possibility of developing a methodological approach, where the restoration of the lost subjectivity of the individual will become one of the methodological foundations of the psychology of homelessness.
Background. The problem of homelessness is urgent both for Russia and foreign countries. Improving the effectiveness of the re-socialization practices for people living on the street implies a deeper understanding of the psychology of the homeless by social services.
Methodology. This article considers the methodological principles of the historical-evolutionary approach (A.G. Asmolov), the approach to the analysis of cultural and personal development from the viewpoint of the chronotope (N.N. Tolstykh), the principle of supra-situational activity (V.A. Petro¬vsky), the idea of personality development pathways in challenging conditions (D.A. Leontiev), etc.
Conclusions. It is concluded that assistance to the homeless is of an ad hoc nature and mostly includes the provision of material and emergency support. The authors propose a comprehensive model based on the idea of the homeless personality returning and upholding the following principles: 1) retention of activity on the side of the person, 2) effort on the part of the person, 3) maintenance of oversituational activity, 4) reliance on the personality, its potential, 5) support and organization of social relations, 6) polysystem.
Psychodiagnostics of Technophobia and Technophilia: Development and Testing a Questionnaire of Attitudes towards Technology for Adolescents and Parents
Authors: Soldatova G.U. , Nestik T.A. , Rasskazova E.I. , Dorokhov E.A.
Published: December 2021

Background. The technological progress of the last two centuries of human history makes it relevant to study human attitudes to digital technologies, in particular the study of such socio-psychological phenomena as technophobia and technophilia, not only for marketing purposes, but also to understand the socio-psychological mechanisms of social change.
Objective. To develop and validate the Technology Attitude Scale that takes into account cognitive and emotional aspects in adolescents and parents of adolescents 14—17 years old.
Study design. The study was carried out in a correlation design and included full-time filling of the methods by all respondents.
Participants. 448 parents of adolescents 14—17 years old and 360 adolescents 14—17 years old from six cities of the Russian Federation.
Methods. Participants filled out Technology Attitude Scale and appraised their user activity, Internet addiction tendencies, parental mediation strategies, and the frequency of using gadgets during performing various daily activities. For data processing, exploratory and confirmatory factor analyses, Cronbach coefficient alpha in the IBM SPSS Statistics v. 22.0, the EQS software package and statistical packages as part of the R programming language.
Results. The structure of the scale was refined based on the results of exploratory and confirmatory factor analysis and included four subscales: technophilia, technophobia, technorationalism, and technopessimism (Cronbach’s alpha 0.66—0.88). Technophilia and technorationalism dominate in the profile of attitudes towards technology. For parents, the emotional aspects of attitudes towards technology are associated with user activity and use of gadgets in everyday activities. In adolescents, technophilia is associated only with the use of gadgets in everyday activities. In adolescents, the experience of parental restrictions and technical control of their online activity is associated with a negative attitude towards technologies and the difficulties of a rational attitude towards them, while active parental mediation is associated with a higher level of technorationalism.
Conclusion. The Technology Attitude Scale is a reliable scale that can be used in psychological research.
Social Ostracism Paradigms O’Cam, O’Train, Cyberball: the Experience of Pilot Research (Russian Federation)
Authors: Boykina E.E.
Published: December 2021

Objective. Approbation of techniques that allow simulating a situation of social ostracism (ignoring, exclusion, rejection).
Background. Social ostracism can be fleeting or manifest itself in a chronic protracted form, leading to depression, causing a sense of loss of meaning in life, and in extreme cases results in an antisocial reaction. The study of this phenomenon in the realities of Russian reality poses a number of theoretical (lack of an established theoretical basis) and, as a consequence, methodological problems for domestic scientists.
Study design. Three experiments were conducted with different scenarios and methods of simulating inclusion/exclusion conditions, the technique of psychological debriefing was used. Threatened Needs Scale-Ostracism (Boykina, 2019 adaptation) was used in two experiments in two modifications: for adults and children. The calibration of the “Cyberball” inclusion/exclusion conditions parameters was carried out.
Participants. The study included three samples: the «O’Train» approbation: N=66, 61 female, 5 -male, M – 18,3; «Cyberball»: N=96, 57 female, 39 male, M – 12,84; «O’Cam»: N=37, 19 female, 18 male, M – 13,6.
Measurements. Experimental method, self-reporting methodology Scale of Threatened Needs- Ostracism, computer program “Cyberball” (Williams, Cheung, Choi, 2000), qualitative data analysis.
Results. The tested techniques have confirmed their reliability as a method of simulating the situation of social ostracism.
Conclusions. The following admission selection criteria are formulated as recommendations: 1) simulation of conditions of ignoring/exclusion/rejection, 2) the least psychological discomfort of the object, 3) viability of the research organization (including the number of participants in the experiment and the reliability of the legend), 4) avoidance of confrontation of participants. The methods tested by the authors can be used both in research and in applied goals, taking into account compliance with the ethical principles of psychological experiment.
International Environmental Protection in Armed Conﬂicts: Traditional Legal Regulation and Interpretation Novelties
Authors: Sokolova N. A.
Published: December 2021

The paper is devoted to international legal protection of the environment during armed conflicts. The author emphasizes that armed conflicts, both international and non-international, continue to be one of the most serious threats to a healthy environment. An armed conflict taking place in the environment invariably poses a threat to ecosystems.

The author summarizes that in international law there are special norms for the protection of natural environment during armed conflicts. At the same time, increasing the level of protection requires a clearer definition of the scope of application of customary law and the further development of treaty rules. While the objectives of protecting the natural environment are linked to the survival and protection of civilians, recognition of environmental protection during armed conflict as such constitutes an important trend. International law calls on States to enter into agreements that provide for additional protection of the natural environment during armed conflicts. The concept of “protecting the natural environment” in international humanitarian law refers to a wide range of obligations that can help protect the natural environment or its parts from damage. A high threshold for potential harm continues to pose the risk that such protection is not fully applicable in practice. There is an obvious tendency to use the potential of the principles of international environmental law when applying the norms of international humanitarian law. Thus, even in cases where the assessment of new means and methods of warfare does not provide scientific certainty with regard to their impact on the natural environment, this does not absolve the parties to the conflict from taking appropriate precautions. It is not enough that there are important rules of international humanitarian law protecting the natural environment during armed conflict; they need to be better disseminated, implemented and enforced, as well as validated and clarified.
Law Abidance / Delinquency through the Lens of Neurobiology
Authors: Kashanina T. V.
Published: December 2021

The paper is interdisciplinary in nature: it is written at the intersection of legal theory and neuroscience. In legal science, the study of the causes of illegal behavior is carried out at different levels (psychological, sociological and philosophical). The novelty that this paper introduces is that it is proposed to conduct research on the causes of illegal behavior at the neurobiological level, which is almost more powerful than those mentioned above. The paper is aimed at solving the problem of using a neurobiological portrait of a person or a social group to prevent offenses. According to neurobiological features, people are divided into 4 categories: visual, auditory, kinesthetic and digital, which implies a different characteristic of them in terms of law abidance/delinquency. Knowledge of the neurobiological features of the subjects of law will allow the state to act “ahead of the curve”, and not wait for the commission of illegal actions to begin the fight against them. The question of the gender brain (or the features of the female and male brains) and its influence on the nature of delinquency is being investigated. The features of the adolescent brain are considered, which are able to activate not only prosocial behavior, but also antisocial. The use of neuroscience to explain the antisocial behavior of adolescents allows a deeper understanding of juvenile delinquency. The understanding of the peculiarities of the adolescent brain, it seems possible to develop many different measures in advance to direct their energy in the right way. Finally, neurobiological knowledge is also used to study the legal behavior of older people. The gerontological brain has both advantages and disadvantages. Despite the fact that older people are law-abiding, and the level of delinquency among them is law, it is extremely shortsighted to abandon the behavior of older people in the field of law, especially in the light of demographic problems existing in Russia.
Political Principles of the Cuban Socialism Doctrine: Towards the History of Emergence and Development
Authors: Sergeev A. L.
Published: December 2021

Socialism as a political trend and a system of certain ideological positions has been experiencing a kind of renaissance in recent years. Cuban socialism is a special phenomenon of recent history, which has continuously existed and developed for six decades in the most difficult conditions of the North American foreign economic blockade and in the presence of other threats of a socio-political nature. Solving numerous issues of practical and transformative activity, the Cuban socialist doctrine generalized and formulated many new theoretical propositions, a number of which will be able to significantly influence the formation of an updated socialist doctrine claiming the ideological and semantic possibility of a world alternative.

The paper analyzes the basic principles characterizing the doctrine of Cuban socialism in matters of ethics, relations with the church, the foundations of education, assessing the prospects of the institution of statehood in the 21st century, and evaluating other political projects that had points of joint intersection with Cuban socialist theory and practice.

Cuban socialism is a specific phenomenon that arose as a result of a number of objective and subjective factors. By the end of the 1950s the century-and-a-half struggle of Cubans against colonial and then neocolonial exploitation were intensified by the Soviet vector and its influence in the international arena as the second great power with the aggravation of the Cold War. These factors together with the “island life” on a par with the Catholic, peasant community of the majority of the population, the sacrifice and service of several generations of the young Cuban elite, the combination of the cult of courage and guerrilla traditions with the special cruelty and repressiveness of the Spanish colonial apparatus of the 21st century, and then relying on American support of the Cuban dictatorships of the first half of the 20th century is a set of factors that gave rise to the “spring effect” in the social consciousness of the island society. In addition to objectively determined reasons, a huge role in the long-term maturation of the conditions for the emergence of the Cuban socialist project was played by the traditional personality for the Ibero-American culture. All of the above would have been impossible outside of the long-term activities of a whole galaxy of brilliant Cuban political leaders.
Pilonidal Sinüsün Cerrahi Tedavisinde Limberg Flep ile Karydakis Flep Karşılaştırılması: Retrospektif Klinik Çalışma
Authors: DAL M. Burak , ALTUN Hasan
Published: December 2021

Amaç: Pilonidal sinüs hastalığında altın standart tedavi metodu halen tartışmalı olmakla birlikte hastalığın tedavisinde, pek çok farklı görüş ve geliştirilmiş cerrahi metotlar vardır. Bizim bu çalışmada amacımız Karidakis flep ve Limberg flep tekniği uygulanan pilonidal sinuslerde iki cerrahi tekniğin erken dönem sonuçlarının kıyaslanmasıdır.

Gereç ve Yöntem: Çalışmamıza Ocak 2009- Eylül 2009 tarihleri arasında sakrokoksigeal pilonidal sinüs tanısı ile Karydakis flep (Grup K) ve rhomboid eksizyon + Limberg flep (Grup L) cerrahisi uygulanan toplam 109 hasta dâhil edildi. Hasta seçiminde akut pilonidal sinüs apsesi olanlar ile komplike pilonidal sinüsü olanlar çalışmaya alınmadı. Ayrıca takip için kontrollerine gelmeyen ve ulaşılamayan hastalar çalışma dışında bırakıldı.

Bulgular: Grup L’de ki hastaların 67 erkek - 8 kadın, yaş ortalaması 26.34 (13-56) idi. Grup K’deki hastaların 26 erkek - 8 kadın, yaş ortalaması 27,42 (16-60) idi. Başvuru şikâyetleri sıklık sırasıyla akıntı, şişlik ve ağrı şeklindeydi. Hastaların 75’sine limberg flebi, 34 erkek hastaya ise Karydakis tekniğine uygun flep uygulandı. Limberg flep tekniği uygulanan toplam 75 hastadan 4 hastada ve Karydakis flep tekniği uygulanan toplam 34 hastadan 2 hastada postoperatif enfeksiyon gelişmiştir. Limberg flep tekniği uygulanan toplam 75 hastadan 3 hastaya nüks pilonidal sinüs tanısı konmuştur. Karydakis flep tekniği uygulanan toplam 34 hastadan 1 hastaya nüks pilonidal sinüs tanısı konmuştur.

Sonuç: Pilonidal sinüs hastalığında tüm şartları karşılayabilecek, ideal bir yöntem yoktur. Literatürde en düşük nüks oranları rhomboid eksizyon ve limberg flep tekniği yöntemindedir. Karydakis yöntemi hastanede yatış süresi, geç komplikasyonlar ve nüks oranında bir değişiklik oluşturmaksızın pilonidal sinüs tedavisinde Limberg flep yöntemine bir alternatif olarak kullanılabileceği kanısındayız.
COVID-19 Pneumonia and Acute Kidney Injury: Delivery of Hemodialysis Therapy
Authors: KEMEÇ Zeki
Published: December 2021

TherapyCoronavirus disease 2019 (COVID-19) is a highly infective disease caused by the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2). It has been shown that the patients who contracted COVID-19 disease are exposed to kidney damage through acute kidney injury (AKI), mild proteinuria, hematuria or slight elevation in creatinine, probably as a result of kidney tropism of the virus and multiorgan failure. In this case report, a 69-year-old patient with a background of comorbid conditions, such as hypertension (HT), diabetes mellitus (DM) and a history of tuberculosis, had COVID-19 pneumonia associated with AKI. He was followed in intensive care units (ICU) due to the signs of hypoxia, hypotension and anuria. Hemodialysis (HD) was administrated in three sessions. The patient responded to the treatment, and his kidneys were fully recovered.
Pediatri Ünitelerinde Çalışan Hemşirelerin Duyarlı Sevgi Düzeyleri ile Merhamet Düzeyleri Arasındaki İlişki
Authors: ORHAN Elif , KOKCU DOGAN Aysel
Published: December 2021

Amaç: Araştırma pediatri ünitelerinde çalışan hemşirelerin duyarlı sevgi düzeyleri ile merhamet düzeyleri arasındaki ilişkiyi belirlemek amacı ile yapılmıştır.
Gereç ve Yöntem: Araştırma, İstanbul ilinde bulunan beş özel ve iki devlet hastanesinin pediatri ünitelerinde gerçekleştirildi. Araştırmanın evrenini; pediatri ünitelerinde çalışan 350 hemşire, örneklemini ise araştırmaya katılmaya gönüllü toplam 278 hemşire oluşturdu. Veriler “Duyarlı Sevgi Ölçeği” ve “Merhamet Ölçeği” kullanılarak toplandı.
Bulgular: Araştırmaya katılan hemşirelerinin %88.8’inin kadın, %46’sının 26-35 yaş aralığında, %76.3’ünün lisans ve üzeri mezunu olduğu, %66.5’inin devlet hastanesinde çalıştığı belirlendi. Hemşirelerin “Merhamet Ölçeği” toplam puan ortalaması 69.827±8.968; “Duyarlı Sevgi Ölçeği” toplam puan ortalaması ise 103.590±19.427 bulundu. Araştırma grubundaki hemşirelerin Merhamet ölçeği toplam puanı ile tüm alt boyutlar arasında pozitif ilişki bulundu. Duyarlı Sevgi Ölçeği toplam puan ortalaması” ile “Merhamet Ölçeği Bağlantısızlık Alt Boyutu” arasında pozitif, “Sevecenlik Alt Boyutu” arasında ise negatif ilişki (p
Üst Gastrointestinal Sistemde Yabancı Cisimlerin Değerlendirilmesi: Tanı ve Tedavi
Authors: ÇANTAY Hasan , ANUK Turgut , SÜLÜ Barlas , BİNNETOĞLU Kenan , ALLAHVERDİ Tülay , GÖNÜLLÜ Doğan
Published: December 2021

Amaç: Araştırmada, yabancı cisim yutulması nedeniyle genel cerrahi kliniğinde acil endoskopi işlemi uygulanan ve endoskopi işleminin yetersiz kaldığı durumlarda cerrahi yöntem ile tedavi edilen vakaların değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntem: Tanımlayıcı nitelikte yapılan araştırmanın verileri yabancı cisim yutan hastaların dosyalarından elde edilmiştir. 2017-2020 yılları arasında 21 yabancı cisim yutma vaka dosyaları taranmıştır. Araştırmanın verileri SPSS paket programında analiz edildi. Analizlerde frekanslar, yüzde ve ortalama, ortanca kullanıldı.

Bulgular: Yabancı cisim yutanların yarıdan fazlası (%52.3) erkektir. Yabancı cisimlerin %57.1 organik olup, en fazla en fazla üst özofagusta yerleşmiştir (%47.6). En sık görülen semptom disfaji (%38.1), %57.1’i ayaktan tedavi edilerek yatışa gerek duyulmamıştır. Komplikasyon oranı %14.3’tür. Vakaların %90.5’i endoskopi ile tanı konularak tedavi edilmiştir.

Sonuç: Yabancı cisimlerin gerek tanı ve gerekse tedavisinde en önemli yöntem endoskopik işlemdir. Endoskopinin yetersiz olduğu sınırlı sayıda vakada ise cerrahi gerekmektedir.
Medical Treatment in Covid-19: Changes in Post-treatment Laboratory Results and CT Findings
Authors: KORKMAZ İnan , DİKMEN Nursel
Published: December 2021

Objective: Today, the symptoms, imaging features and laboratory findings of the disease are known, but the treatment of the Coronavirus disease 2019 has not been clarified. In this study, we aim to investigate the efficacy of favipiravir in patients who do not need invasive mechanical ventilation, by examining the post-treatment laboratory and computed tomography findings compared to the hydroxychloroquine which removed from the treatment guide.
Methods: In our study, 49 patients diagnosed with Coronavirus disease 2019 and treated with hydroxychloroquine and favipiravir were examined. The patients were divided into 3 groups according to their treatment modalities. The changes in the pre- and post-treatment laboratory findings and computed tomography imaging of the patients in these 3 groups were examined.
Results:There was no statistically significant difference between the rates and types of lesion patterns observed on thorax computed tomography in the groups. The most common lesion pattern in each group was the presence of ground glass opacity + consolidation in 18 patients (81.8%) in the hydroxychloroquine group, 7 patients (70%) in the favipiravir group and 10 patients (58.8%) in the hydroxychloroquine + favipiravir group. In all 3 groups, there was a statistically significant improvement in C-reactive protein, ferritin, fibrinogen values and computed tomography scores after treatment and there was no statistically significant difference between drugs.
Conclusion: In this study, we found no significant superiority of favipiravir in terms of changes in laboratory and computed tomography findings after treatment in Covid-19 patients who do not need intensive care compared to hydroxychloroquine.
Testicular Seminomatous and Nonseminomatous Germ Cell Tumors: Clinical and Pathological Features
Authors: GÜRSOY Didar , SEÇİNTİ İlke Evrim , GOKALP Fatih , HAKVERDİ Sibel , GÖRÜR Sadık
Published: December 2021

Objective: In the present study, it was aimed to investigate the differences between the clinical and histopathological features of testicular seminomatous and non-seminomatous germ cell tumors diagnosed in our center in the recent 10 years.

Methods: All the patients in whom diagnosis of testicular germ cell tumor was histologically confirmed in our center between January 2010 and May 2020 were involved in the study. The medical records of the patients were screened and Hematoxylin-Eosin (H+E) stained slides of the patients were re-evaluated. The tumor classification and primary tumor stage determination (pT) were carried out in accordance with the 2016 WHO Classification of Tumors of the Urinary System and Male Genital Organs.

Results:The morphology of seminoma (SEM) and non-seminomatous germ cell tumors (NSE-GCTs) were identified in 27 (51%) and 26 (49%) of the study patients, respectively. In the SEM group, patient ages ranged between 23-55 years (min-max) and median age was 33 years (IQR=26.0-41.0) while those values for the NSE-GCT cases were 16-44 years and 28 years (IQR=22.75-29.5), respectively. The evaluation of the pTs without subgroup discrimination demonstrated that 21 (39.6%), 31 (58.5%) and 1 (1.9%) of the tumors were Stage 1, Stage 2 and Stage 3, respectively.

Conclusion: Testicular cancers are the most frequently seen malignancy in the young males and its incidence has increased in the recent years. The complete cure rate is approximately 100% thanks to early diagnosis as well as high chemosensitivity and radiosensitivity of these tumors.
Romatoid Artritli Hastaların Perspektifinden Yaşam Deneyimleri: Fenomenolojik Bir Yaklaşım
Authors: ŞENTÜRK Sibel , KİMYON Gezmiş
Published: December 2021

Amaç: Araştırmanın amacı, romatoid artritli hastaların perspektifinden yaşam deneyimlerinin derinlemesine aktarılmasıdır.

Gereç ve Yöntem: Tanımlayıcı ve fenomenolojik olarak tasarlanan bu araştırma, 15 Temmuz- 15 Ağustos 2020 tarihleri arasında romatoloji polikliniğine muayene olmak için gelen ve en az 1 yıldır romatoid artrit tanısı olan toplam 24 birey ile tamamlanmıştır. Veriler, araştırmacılar tarafından oluşturulan “Hasta Tanıtım Formu” ve “Yarı Yapılandırılmış Görüşme Formu” ile yüz yüze görüşülerek toplanmıştır. Görüşmeler sırasında romatoid artritli hastaların ifadeleri ses kayıt cihazı ile kaydedilmiştir. Verilerin değerlendirilmesinde içerik analizi yöntemi kullanılmıştır.

Bulgular: Yapılan kodlamalar sonucunda 3 tema belirlenmiştir. 1) Tanıya verilen ilk tepki, 2) Romatoid artrit semptomlarının hastalar üzerindeki etkisi, 3) Baş etme stratejileri. Romatoid artritli hastaların bir kısmı ilk tanı konulduğunda inkâr ve öfke yaşarken bir kısmı da aile üyelerinde aynı hastalık bulunduğu için kabullenmiştir. Hastalıkla birlikte yaşamları fiziksel, duygusal, emosyonel, sosyal ve ekonomik açıdan etkilenmiştir. Hastalıkla başa çıkarken tedaviye uyum sağlama, aile desteği alma, öz-yönetimlerini güçlendirme ve dine yönelme gibi yöntemleri kullandıkları belirlenmiştir.

Sonuç: Bu çalışma, romatoid artritin hastaların yaşamlarını tanı konduğu andan itibaren nasıl etkilediğini ve hastalıkla nasıl baş ettiklerini ortaya koymaktadır. Sağlık profesyonellerinin hastalık yönetiminde hastanın bakış açısını dikkate alma ve holistik bir yaklaşımla tedavilerini oluşturmaları önerilmektedir.
Development of a Method for the Extraction of the Total Proteome of Bacillus anthracis Spores
Authors: Koteneva E.A. , Tsygankova O.I. , Kalinin A.V. , Shcherbakova V.Yu. , Rodionov I.S. , Serdyukov V.V. , Abramovich A.V.
Published: December 2021

We have developed a method for obtaining the total proteome of Bacillus anthracis spores, which combines efficient protein extraction with reliable disinfection of samples. We used 7 strains of B. anthracis: 4 plasmid-free, 3 diplasmid, one of which with an atypical type of capsule formation in air. The schemes for isolating the total spore proteome were tested using various lysis solutions in the presence of bacterial protease inhibitors, with the inclusion of the stages of treatment of spores with trichloroacetic acid and mechanical disintegration and with their exclusion. The quality and completeness of the extraction of the total proteome of the spores of the samples was assessed in one-dimensional (1D) and twodimensional (2D) electrophoresis. Treatment of spores with trichloroacetic acid increased the reliability of material disinfection and reduces the loss of the final product. Mechanical disintegration after treatment of spores with lysing solutions increases the completeness of extraction of spore proteins in a wide range of molecular weights and facilitated the process of sterilizing filtration. Final filtration of the lysate through a PVDF filter with a pore size of 0.22 μm provided additional decontamination of samples without reducing their quality. Thus, the use of the proposed sample preparation scheme makes it possible to obtain complete protein extracts of spores of B. anthracis strains, suitable for comparative analysis of the proteome and search for a possible correlation with the features phenotypic properties and mechanisms that ensure the preservation of the pathogen anthrax in environmental objects, including soil
Da'wa in Social Media: The Views of Ustad Hanan Attaki and Felix Siauw to The Hijrah Phenomenon
Authors: Muthohirin Nafik
Published: December 2021

This article examines the views of Ustad Hanan Attaki (UHA) and Ustad Felix Siauw, who use social media as a medium of preaching. The utilization of the internet as a new way of preaching Islam has helped shape contemporary forms of religious thinking and behavior for Muslim youth in Indonesia. One of them is marked by the emergence of the trend of hijrah in their community. This study aimed to explain the Islamic views of UHA and Siauw, which have implications for the emergence and development of the hijrah trend. This research focuses on extracting data through observations on a number of predetermined social media accounts, field participation and interviews, and puts forward literature studies on the fragmentation of religious authority as a result of the emergence of a number of popular ustadz who use social media as a new space for preaching. Regarding the fragmentation of religious authority, this article is based on the thesis of Eickelman and Anderson, which states that the current religious authorities are those who have succeeded in transmitting religious texts and preaching them through new media. In more detail, this study discusses two important issues, namely the trend of Islamic da'wa on social media and, in particular, the implications of the Islamic views of UHA and Siauw for the emergence of the trend of hijrah Muslim youth. This article concludes that according to UHA, hijrah is a message of Islamic da'wa that not only tells about individual repentance but also as a current trend that young Muslims must follow. Meanwhile, Siauw interprets it as an effort to awaken the spirit of Muslims to achieve the establishment of the Islamic Khilafah.
Seroprevalence of COVID-19 antibody among patients visiting a large clinic in Uttar Pradesh
Authors: Agrawal Garima , Agrawal Ruchira , Agrawal Harsh , Prajapati Hiren , Yadav Krishna , Agrawal Kamal , Agrawal Chandra Gupta
Published: December 2021

Background: The study was conducted to determine the Coronavirus disease 2019 (COVID-19) antibody titre among patients who visited our clinic in Lucknow in order to find out the prevalence of sero positivity and to determine the association between COVID anti-body titre and positivity to different age groups, sex, and religions etc., if any.Methods: Secondary data analysis was conducted at Lucknow's Sitara polyclinic from patients’ data, who had attended the clinic between May 2021 and July 2021 and had universally undergone COVID antibody testing. COVID antibody (including IgG) levels in patients' blood were determined using Roche's commercial "Elecsys Anti-SARS-CoV2-cobas e411,601,602 system.by Roche which measure by Eclia (electro chemilusence immunoassay) quantitatively antibodies (including IgG). Patients with titres less than 1 u/ml were deemed seronegative for anti –SARS COVID-2, while those with titres greater than or equal to 1 u/ml were declared seropositive.Results: The overall rate of seropositivity was 84.8%. Around 84.5% males and 85.1% females were seropositive. Seropositivity was higher among 18 to 60 years of age. But there was no significant relation between mean age and seropositivity. Muslims had slightly higher seropositivity (86.0%) as compared to non-Muslims (84.5%). There was no significant difference between age and gender having positive COVID 19 antibody titres. Although the incidence of seropositivity was similar between Muslims and Non-Muslims, the antibody titres were significantly higher in Muslim patients.Conclusions: In this part of central eastern UP, incidence of seropositivity could already be as high as 85%, which is a pointer toward adequate herd immunity. COVID-19 does not differentiate on the basis of age, gender or religious affiliations. However, Muslims were found to have more antibody titres compared to non-Muslims, possibly related to life style, degree of exposure to COVID-19 virus and presence of inherent immunity.
Neuroleptic malignant syndrome: case report
Authors: P. Murshid C. , Shareef Bande , Hema Parlapalli
Published: December 2021

Neuroleptic malignant syndrome (NMS) is an infrequent, but potentially life-threatening neurologic emergency associated with the use of neuroleptic or antipsychotic drugs. A 43 years old male with a history of trigeminal neuralgia developed Neuroleptic malignant syndrome while receiving Carbamazepine and Amitryptylline. Treatment is mainly supportive and includes withdrawal of the neuroleptic medication and, possibly, administration of drugs such as dantrolene and bromocriptine. Complications of NMS include acute renal failure and acute respiratory failure. The possible etiologies, triggering factors and treatment are discussed with reference to existing literature.
Etiology and clinical spectrum of acute undifferentiated fever illness in patients in a tertiary care hospital Sheri Kashmir institute of medical science Soura, Jammu and Kashmir
Authors: Gazala Sheenam , Chesti Mohmad Saleem , Mushfiq Syed
Published: December 2021

Background: Current study aimed at s to delineate the etiology and clinical parameters associated with AUFI presenting to emergency department in a tertiary care hospital.Methods: This was a prospective hospital based study carried out at emergency medicine, SKIMS hospital, Soura Kashmir, India July 2017 to august 2018. Patients with acute undifferentiated fever were enrolled. Descriptive statistics were calculated in terms of mean±SD for continuous variables like age of the patients and duration of fever, Frequency and percentage were used to analyse categorical variables such as causes of fever and gender, while as descriptive analysis was calculated in terms of mean±SD for continuous variables like age of the patients and duration of fever.Results: Total numbers of patients included were 174, among these 112 (64.3%) were males and 62 (35.6%) were females. Most patients were diagnosed enteric fever (N=59, 33.9%) followed by UTI (N=25, 14.3%) dengue (N=12, 6.8%) and malaria (N=8, 4.5%) while rest of cases were associated with other viral illnesses (N=70, 40.5%) based on clinical basis and inconclusive laboratory results.Conclusions: Enteric fever was found to be the most common cause of acute undifferentiated fever followed by dengue and other viral illnesses, although causes and clinic spectrum of AUFI is varied.
Idiopathic intracranial hypertension leading to bilateral optic atrophy in a patient with recent COVID-19 infection: a case report
Authors: Yarky Anu , Kumar Vipan , Chauhan Nidhi , Sharma Priyesh
Published: December 2021

Neurologic complications are common in patients hospitalised with COVID-19 infection. Most common complications are myalgias, headaches, encephalopathy and dizziness. Uncommon complications are stroke, motor and sensory deficits, seizures, ataxia and movement disorders. Multiple neuro-ophthalmological manifestations have also been reported in association with COVID-19. These complications may be the result of a range of pathophysiological mechanisms like hypoxic neuronal injury during active COVID-19 infection, RAS dysfunction, immune dysfunction and direct injury by the virus etc throughout the course of the disease. Here we reported a case of neuro-ophthalmic complication of Idiopathic intracranial hypertension (IIH) followed by bilateral optic atrophy in a middle-aged man with recent COVID-19 infection. He presented to the emergency with complaints of headache, dizziness and sudden painless bilateral diminution of vision for 3 days. His fundus examination was suggestive of bilateral papilledema, his MRI brain was normal and opening pressure of CSF was raised on lumbar puncture. His MRV was normal, there was no evidence of CSVT. He was started on steroids and acetazolamide. His headache improved but there was no improvement in visual acuity. Repeat fundus showed pale disc and MRI orbit was suggestive of bilateral optic atrophy.
Methicillin resistant Staphylococcus aureus - importance of appropriate empirical therapy in serious infections
Authors: Reddy Pavan Kumar Nanchary , Sutar Anand , Sahu Sambit , Thampi Bini , Keswani Neha , Mehta Kapil D.
Published: December 2021

India has been titled the capital of antimicrobial resistance in the world with the centre for disease dynamics, economics and policy (CDDEP) predicting two million deaths in India by 2050. As per the World Health Organisation’s global priority pathogen list of 2017, methicillin resistant Staphylococcus aureus (MRSA) has been classified as a ‘high priority’ pathogen due to its association with increased mortality rate, rising prevalence of resistance and increased burden on healthcare settings. A recent report by Indian Council of Medical Research signifies the exponential rise in the prevalence of MRSA in India, from 29% in 2009 to 39% in 2018. Serious MRSA infections are commonly associated with poor clinical outcomes coupled with increased hospitalisation stay and cost. Therefore, early identification and appropriate empiric treatment of MRSA plays a crucial role in healthcare settings. However, the constant rise in multi-drug resistance to the currently available anti-MRSA agents as well as their compromised safety profile limits its clinical use to manage severe MRSA infections. This review article explores the implications of severe MRSA infections and inappropriate empirical therapy on the clinical as well as economic outcomes. In addition, it also highlights limitations of the currently available anti-MRSA agents and the need for newer agents to manage multi drug resistant (MDR) gram positive infections.
Role of platelet parameters and hematological profile in dengue positive cases
Authors: Passi Rashim , Baviskar B. P. , Karle R. R.
Published: December 2021

Background: Dengue is an endemic in tropical and sub-tropical regions of the world and also in various parts of India. Recent evidence indicates that platelet indices can be used to assess the severity and prognosis of dengue. This study aimed to assess the role of the platelet indices-mean platelet volume (MPV), platelet distribution width (PDW), platelet to large cell ratio (P-LCR), plateletcrit (Pct) and hematological parameters like hemoglobin (Hb), hematocrit (Hct) with the platelet count in dengue NS1 antigen positive cases.

Methods: An observational cross-sectional study conducted on cases of dengue over a period of 3 months admitted with serological positivity (NS1 antigen) in a tertiary care hospital, Loni. The platelet indices like MPV, PDW, Pct, P-LCR and hematological parameters like Hb, Hct were noted using Sysmex XN-3100 Automated hematology analyzer and compared with platelet count.

Results: Relationship between various platelet indices like MPV, PDW, P-LCR and PCT and hematological parameters like Hb, TLC and Hct were related with platelet count. Dengue positive cases were inversely related to MPV, PDW, P-LCR, Hb and Hct and directly related to Pct. In the present study Pct, P-LCR, Hb and Hct were statistically significant in correlation with platelet count.

Conclusions: Pct, P-LCR, Hb and Hct along with platelet count can be used to assess the predictive outcomes in case of dengue infection.

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Association of sensorineural hearing loss in type 2 diabetes mellitus patients: an analytical cross sectional study
Authors: Jyoti Jeevan , Ali Ihsan , Abbas Syed Waseem
Published: December 2021

Background: The association of sensorineural hearing loss in diabetes mellitus patients is known since decades, yet there is no clear consensus among previous studies, with respect to the prevalence of SNHL in type 2 diabetes patients and the effect of duration and control of diabetes on hearing acuity. Hence the objectives of this study are to find the prevalence of SNHL in type 2 diabetes patients and to find the effect of duration and control of diabetes on hearing loss.

Methods: The present study was conducted on 100 type 2 diabetes patients and age and gender matched 100 non- diabetic controls in the age group of <50 years, selected based on inclusion and exclusion criteria. After detailed history taking and clinical examination, all subjects underwent FBS, PPBS estimation and HbA1c evaluation was done for diabetic patients. All underwent pure tone audiometry, DPOAE and BERA and the findings were recorded and analyzed.

Results: Diabetes patients had insidious onset, gradually progressive, bilaterally symmetrical SNHL. SNHL is prevalent in 73% of type 2 diabetes patients compared to 16% of controls. It is aggravated with the increasing age and duration of diabetes. Poor control of diabetes showed increased prevalence of SNHL compared to good control of diabetes.

Conclusions: There is increased prevalence of SNHL in type 2 diabetes patients and it is more evident in patients with long duration of diabetes and more pronounced in patients with poor diabetic control.