bluuebunny/crossref_metadata_2025 huggingface dataset:
Difficulties in mathematical language and representation among elementary school students when solving word problems
Authors: Agusfianuddin Agusfianuddin , Herman Tatang , Turmudi Turmudi
Published: September 2024

Difficulties in mathematical language and representation were the dominant difficulties in solving word problems for students in elementary school. The research aims to analyze students' mathematical language and representation difficulties when solving word problems. The research subjects were 114 fifth-grade elementary school students selected using a purposive sampling technique with different mathematical abilities. The research was conducted at an elementary school in Sumbawa District, West Nusa Tenggara, Indonesia. Data collection techniques included tests, questionnaires, and interviews. The research results show that students' difficulties in mathematical language were dominant indicators of sentences. Students had difficulties in mathematical representation indicators, which were dominant in symbols. The factors that cause difficulty for high, middle, and lower ability students are unaccustomed to solving word problems and using problem-solving procedures, difficulty with concepts, difficulty with reasoning, difficulty understanding what is known and what is being asked, not being careful in reading the problem, and difficulty with long sentences. Student word problem-solving is in the low category.
Improving U-Net Performance for Tumor Segmentation Using Attention Mechanisms
Authors: Wu Zetai , Liu Weifa , Chang Jing
Published: September 2024

U-Net is a widely recognized neural network model for medical image segmentation, renowned for its efficiency in extracting features from both current and past input data. However, traditional U-Net models exhibit limitations in extracting edge features, particularly in medical CT images characterized by complex gray distributions and close pixel intervals. This leads to suboptimal performance, with low accuracy, recall, intersection over union (IoU), and F1-score. This research proposes an improved U-Net model incorporating an attention mechanism to enhance tumor segmentation accuracy and efficiency. The attention mechanism strategically weights important features, directing the network to focus on task-relevant areas. Experimental results demonstrate that our proposed attention-based U-Net model significantly improves tumor segmentation performance, achieving notable enhancements in accuracy, recall, IoU, and F1-score. Further validation across diverse datasets confirms the model's generalization ability and superiority compared to the original U-Net method. This research contributes to the advancement of medical image segmentation techniques, highlighting the potential of attention mechanisms in optimizing deep learning models for clinical applications.
Right liver lobe diameter to serum albumin ratio and blood ammonia level as non-invasive predictor for the presence of esophageal varices and the risk of bleeding in patient of cirrhosis of liver
Authors: Md Arifur Rahman  , Tareq Mahmud Bhuiyan  , Israt Rezwana  , Nikhil Chandra Roy  , Abdul Momin  , Safikul Islam  , Ansari MA Jalil  , Sushanta Barua
Published: September 2024

Background: Esophageal varices (EV), a dangerous complication of cirrhosis, are expensive and inconvenient to diagnose with frequent endoscopies. This study explores using blood tests (ammonia level) and a liver size measurement (right lobe diameter to albumin ratio) as simpler ways to identify patients with EV and at risk of bleeding. Materials and Methods: A cross-sectional study was conducted at BIRDEM General Hospital from April 2019 to June 2021 to investigate non-invasive predictors of esophageal varices in patients with liver cirrhosis. 153 patients with cirrhosis were enrolled and underwent detailed medical history, physical examination, and laboratory tests. Data was collected using standardized forms, checked for accuracy, and analyzed using SPSS 23 software. Results: The study found that patients with esophageal varices (EV) had significantly higher blood ammonia levels (41.13 µmol/l ± 11.22) compared to those without EV (p < .05). Additionally, the right liver lobe diameter was larger in patients with EV (153.92 mm ± 6.54) and the ratio of this diameter to their serum albumin level was also significantly higher (3.89 ± 0.91, p < .05).Interestingly, a ratio of right liver lobe diameter to serum albumin greater than or equal to 2.95 identified patients with EV with 100% sensitivity and 86.4% specificity, offering a high degree of accuracy (86.4%). Blood ammonia levels above 33.35 µmol/l showed slightly lower accuracy (78.4%) with 79.4% sensitivity and 72.7% specificity. The study also followed the patients for bleeding complications. Nearly 38.4% experienced bleeding within 3 months, and a significant portion (65%) had both high right liver lobe diameter to albumin ratio and elevated blood ammonia levels at the 6-month mark. Conclusion: This study found that the higher value of both the Right Liver Lobe Diameter to Serum Albumin Ratio and Blood Ammonia Level were significantly associated with the presence of esophageal varices (EV) among patients with liver cirrhosis and both of them can be used as non-invasive predictor of EV among patients with liver cirrhosis. However, further study is recommended to validate these findings.
DAMPAK DIGITALISASI BANKING TERHADAP KEPUASAN NASABAH PADA BCA KCP HASANUDIN JAKARTA
Authors: Sabilal Ikbal , Hartono Darwin
Published: September 2024

Teknologi pada saat ini bukan hanya diaplikasi, namun telah memasuki seluruh aspek kehidupan tak terkecuali dunia bank yang telah mulai memanfaatkan teknologi untuk pelayanan kepada nasabah. Dengan perkembangan teknologi saat ini, layanan bank mengalami perubahan drastic dan mengarah kepada layanan perbankan digital (digital banking). Layanan ini secara spesifik fokus kepada pemenuhan kebutuhan nasabah dengan memanfaatkan seluruhnya teknologi melalui perangkat (device) dan aplikasi (software) sebagai delivery channel. Sektor bank tidak luput dari pengaruh perkembangan teknologi. Perkembangan digitalisasi membuat pelaku bisnis di sektor industri jasa perbankan harus memahami kebutuhan dan prioritas masyarakat akan produk maupun jasa perbankan yang terus mengalami peningkatan. Saat ini dunia perbankan berlomba-lomba mengembangkan baik produk ataupun layanan berbasis teknologi. Makna penulisan penelitian ini adalah menganalisa dampak digitalisasi banking terhadap kepuasan nasabah pada BCA KCP Hasanudin Jakarta. Kategori penelitian adalah berkategori asosiatif dan kuantitatif sebagai pendekatannya. Adapun jumlah responden dalam penelitian adalah nasasbah BCA KCP Hasanudin Jakarta sebanyak 50 orang. Dengan demikian, maka seluruh nasabah bank dijadikan sebagai responden atau dinamai dengan istilah sensus atau sampel jenuh dalam sampling tekniknya. Instumen penelitian ini adalah kuesioner dengan dibantu skala likert dan dokumentasi. Kesimpulan dalam penelitian ini yaitu digitalisasi banking berpengaruh positif terhadap kepuasan nasabah yakni sebesar 66,8% sehingga dapat dimaknai bahwa apabila digitalisasi banking baik, maka nasabah akan merasa puas, senang, dan akhirnya loyal terhadap BCA. Adanya mesin digital yang ada di BCA (CS Digital, eService, dan Star Teller) dapat mengurangi antrian, menghemat waktu nasabah, mudah digunakan, fitur-fitur lengkap, tidak pernah terjadi gangguan sistem, dan dijamin keamanannya. Oleh karena itu, digitalisasi banking sudah sesuai dengan yang diharapkan nasabah serta dapat meningkatkan kinerja dan produktivitas nasabah. Dengan pra syarat normalitas melalui uji liliefors dinyatakan data normal dengan demikian persebaran data yang didapatkan dinyatakan normal dan terdistribusi baik.
MEDIA SOSIAL SEBAGAI PENUNJANG KOMUNIKASI BISNIS DI ERA DIGITAL
Authors: Nadia Aprilia  , Bambang Permadi  , Faiz Aqila Izura Atanta Berampu  , Suci Andini Kesuma
Published: September 2024

Di era digital ini kita mengetahui bahwa pesatnya perkembangan teknologi informasi, komunikasi dan digital sangat berdampak pada pengembangan bisnis saat ini. Pesatnya perkembangan teknologi ini melahirkan pengembangan bisnis digital yang mana kini bisnis menggunakan digitalisasi berupa media sosial sebagai alat komunikasinya. Hadirnya media sosial memudahkan bisnis dalam melakukan komunikasi dengan konsumen/pelanggan, tidak hanya itu  media sosial juga dijadikan sebagai sarana dalam melakukan pemasaran (marketing) oleh para pebisnis untuk mengembangkan usaha mereka. Artikel ini ditulis dari serangkaian data yang diambil dari berbagai sumber dari internet yang dilakukan dengan merivew beberapa jurnal, buku dan website yang mana penelitian ini bertujuan untuk mengetahui apakah media sosial dapat menjadi penunjang komunikasi dalam bisnis di era digitalisasi. Penelitian ini menggunakan pendekatan kualitatif yang mana pendeketan dilakukan dengan cara membandingkan beberapa jurnal dengan menariknya menjadi sebuah kesimpulan sehingga menjadi sebuah artikel yang baru dari penelitian terdahulu yang telah dilakukan sebelumnya oleh peneliti lainnya. Penelitian ini juga menggunakan systematic literatur review (SLR) yang mana teknik pengumpulan data diambil dari penelitian-penelitian terdahulu yang telah tervalidasi. Artikel ini bertujuan untuk mengetahui lebih dalam bagaimana media sosial dapat menjadi penunjang dalam komunikasi bisnis di era digital.
ANALISIS HIGHT ORDER THINKING SKILL BERDASARKAN SELF CONFIDENCE DAN SELF EFFICACY (STUDI PADA MAHASISWA PRODI PENDIDIKAN EKONOMI UNIVERSITAS NURUL HUDA)
Authors: Rohmah Miftakhur , Rahmadani Rafika , Ismail Khafid , Rifa'i Nanang , Damayanti Meli
Published: September 2024

Kemampuan berpikir kritis merupakan salah satu komponen kognitif peserta didik yang menunjang. Factor-faktor yang mempengaruhi berfikir kritis yakni self confidence dan self efficacy. urgensi penelitian yakni untuk mendeskripsikan keterkaitan yang dikontribusikan Self Confidence Dan Self Efficacy terhadap Kemampuan Berfikir Kritis. Pengumpulan data dilakukan dengan observasi pada saat pembelajaran berlangsung denganaspek pengamatan self- confidence dan self efficacy dengan indicator yang telah ditentukan, sertawawancara mendalam untuk menggali informasi yang mendalam. Untuk menganalisis data,teknik yang digunakan yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Keabsahan data yang digunakan yakni teknik triangulasi waktu. Hasil Penelitian Menunjukan Bahwa kemampuan berfikir ktitis kategori tinggi 68,15%. Sedangkan Untuk self efficacy juga dapat dikategorikan baik, dengan adanya persiapan belajar sebelum perkuliahan dan mengumpulkan berbagai referensi sebagai   bahan pembelajaran. Selain itu juga self confidence juga dapat muncul ketika adanya persiapan yang  baik sebelum proses pembelajaran. Hubungan antara berpikir kritis, self-efficacy, dan self- confidence, sangat penting dalam keterampilan berpikir kritis.
EFEKTIVITAS SISTEM AKUNTANSI MANAJEMEN, SISTEM PENGENDALIAN MANAJEMEN, DAN KETIDAKPASTIAN LINGKUNGAN TERHADAP KINERJA MANAJERIAL DENGAN DESENTRALISASI SEBAGAI VARIABEL MODERASI
Authors: Difla Ulil , Sabaruddin  , Asmanah Siti
Published: September 2024

Ketidakpastian yang dihadapi oleh perusahaan dapat mempengaruhi efektivitas sistem akuntansi manajemen dan sistem pengendalian manajemen, Terdapat kebutuhan untuk menilai seberapa efektif sistem akuntansi manajemen dalam menghasilkan informasi yang relevan dan akurat untuk pengambilan keputusan. Penelitian ini bertujuan untuk mengetahui efektivitas sistem akuntansi manajemen, sistem pengendalian manajemen dan ketidak pastian lingkungan terhadap kinerja manajerial dengan desentralisasi sebagai variabel moderasi. Metode dalam penelitian ini adalah kuantitatif dengan sumber data primer. Populasi dalam penelitian ini adalah Rumah Sakit Umum Daerah (RSUD) di DKI Jakarta. Sampel penelitian ini adalah kepala divisi, kepala subbidang, kepala bagian, kepala subbagian serta kepala instalasi dan staf Rumah Sakit Umum Daerah di DKI Jakarta yang berjumlah 104 responden. Analisis data yang digunakan dalam penelitian adalah analisis data Structural Equation Modeling (SEM) dengan pendekatan Partial Least Square (PLS) versi 3.00. Berdasarkan hasil penelitian dengan menggunakan uji hipotesis menunjukkan bahwa Sistem Akuntansi Manajemen berpengaruh signifikan terhadap Kinerja Manajerial artinya H1 Diterima H0 Ditolak. Sistem Pengendalian Manajemen tidak berpengaruh signifikan terhadap Kinerja Manajerial artinya H1 Ditolak H0 Diterima. Ketidakpastian Lingkungan mempunyai pengaruh yang signifikan terhadap Kinerja Manajerial artinya H1 Diterima H0 Ditolak. Desentralisasi tidak memoderasi pengaruh Sistem Akuntansi Manajemen terhadap Kinerja Manajerial artinya H1 Ditolak H0 Diterima. Desentralisasi memoderasi pengaruh Ketidakpastian Lingkungan terhadap Kinerja Manajerial artinya H1 Diterima H0 Ditolak. Desentralisasi memoderasi pengaruh Sistem Pengendalian Manajemen terhadap Kinerja Manajerial artinya H1 Diterima H0 Ditolak.
Aconitine Impedes Cell Motility in MDA-MB-231 Breast Cancer Cells: A Potential Therapeutic Avenue
Authors: Keleş Bartık Didem , Sipahi Murat , İnanç-sürer Şeniz , Oktay Gülgün
Published: September 2024

Purpose: Aconitine, a potent alkaloid from Aconitum plants, has shown promising anticancer properties. The aim of the study is to investigate the effects of aconitine on lateral migration, and matrix metalloproteinase (MMP) activity in MDA-MB-231 triple-negative breast cancer cells.
Material and Methods: A WST-1 viability assay was conducted to determine the effect of aconitine on the viability of MDA-MB-231 cells. Following treatment with non-cytotoxic doses of aconitine, lateral migration was evaluated through wound healing assays. Additionally, gelatin zymography was conducted to analyze MMP-2 and MMP-9 activity and secretion levels.
Results: Aconitine concentrations up to 200 μM did not significantly affect cell viability for up to 72 hours, whereas higher doses (400-600 μM) reduced viability in a time-dependent manner. Aconitine at 200 μM showed a trend towards decreased lateral motility, with a significant reduction at 9 hours post-treatment. Gelatin zymography revealed no alterations in MMP-2 and MMP-9 activity or secretion levels following aconitine treatment.
Conclusion: Aconitine demonstrates limited efficacy in modulating the migratory capacity of MDA-MB-231 cells and does not affect gelatinase activity. Further investigation into underlying mechanisms is necessary, potentially leading to novel therapeutic strategies for triple-negative breast cancer.
Core-Log Depth Adaptive Matching Using RDDTW
Authors:   China University of Petroleum Beijing, Fang Yu , Zhou Jun ,   China University of Petroleum Beijing, Xiao Lizhi ,   China University of Petroleum Beijing, Lia Guangzhi ,   China University of Petroleum Beijing
Published: September 2024

Core-log depth matching is crucial in petrophysical interpretation and reservoir parameter prediction. The accuracy and reliability of core-log matching determine the quality of all subsequent petrophysical and reservoir parameter models. At present, this task is mainly performed manually by geological experts, and the process depends on expert experience and is time consuming and laborious. The existing methods ignore the matching of core-log data similarity and overall trend changes. Given this situation, this paper proposes regularized derivative dynamic time warping (RDDTW), which is used to extract and fuse the shape and trend information between the core and the log porosity curve to realize adaptive depth matching. In addition, the method includes a new weight function, called excessive warping regularized function (EWRF), which is proposed to eliminate the overfitting effect of excessive warping. The study applies the proposed methodology to a data set comprising 10 exploration wells in the Ordos Basin, with an average porosity of 10.31%. Utilizing particle swarm optimization (PSO), the approach iteratively refines optimization. A comparative analysis assesses the method’s effectiveness in core-log matching tasks against traditional Pearson correlation coefficient (PCC) techniques and manual interventions. The results show that RDDTW can realize core adaptive relocation more efficiently and accurately in various strata. Compared with the PCC, the proposed method increases the porosity R2 by 9.62% and decreases the porosity mean square error by 1.57%.
Permeability Anisotropy in Brazilian Presalt Carbonates at Core Scale Using Digital Rock Petrophysics
Authors:   Universidade Federal do Rio de Janeiro, Rocha da Silva Junior Plinio Cancio , Araujo Victor Rodolfo ,   Petróleo Brasileiro S.A. – Petrobras, Surmas Rodrigo ,   Petróleo Brasileiro S.A. – Petrobras, Velloso Barroso Emilio ,   Universidade Federal do Rio de Janeiro, Perosi Fábio André ,   Universidade Federal de São Paulo
Published: September 2024

Presalt carbonate reservoirs exhibit high textural heterogeneity and a complex porous system with pores at different length scales. Absolute hydraulic permeability (Kabs) is a property that depends on the measurement direction and observation scale and is, therefore, influenced by horizontal barriers, fractures, and preferential flow paths. The anisotropy of Kabs is an important parameter in reservoir modeling, and its determination is a challenging task that requires the combination of laboratory measurements with well-log data at different scales. This study proposes a method for upscaling measurements from routine core analysis (RCAL) on horizontal and vertical plugs using medical computed tomography in core samples, employing hydraulic flow unit classification and machine-learning techniques to obtain directional Kabs volumes. Flow simulations are performed on these local permeability volumes in two orthogonal horizontal directions and in the vertical direction, with different vertical investigation windows in order to further upscale the permeability information to the well-log scale. The vertical (Kv) and horizontal (Kh) permeability logs are evaluated by facies and compared to RCAL data from plugs and whole core samples. We hypothesize the existence of distinct hydraulic flow units for different directions in the upscaling methodology. The lack of laboratory data at decimeter scales is a limitation when evaluating the results, but the obtained products are satisfactory in the performed comparisons to available RCAL data. A reduction in the Kv/Kh max ratios is observed with increasing vertical investigation window. The medians of these results are less than 1% in spherulites and vary between 35.64 and 24.33% in stromatolites. There is a higher dispersion of permeability values in spherulites, reflecting the presence of two distinct groups within these facies due to different diagenetic effects, besides a tendency towards isotropy in the horizontal directions. The lower performance in the Kv estimates is related to the inherent uncertainties of the data in this direction, such as the lower CT vertical resolution and the smaller amount of RCAL data. The results can serve as input for predicting Kv at the reservoir scale, either by directly using the permeability logs or by evaluating the behavior of Kv/Kh in facies-based simulations with varying vertical thicknesses. This new approach can be key for accurately upscaling Kv in three-dimensional (3D) reservoir flow models, adjusting the average properties on the sizes and geological classifications of the simulation grid cells.
Characterizing Thin-Bed Responses in Horizontal Wells Using LWD NMR Tools: Insights From a Water Tank Experiment
Authors:   SLB, Ramadan Zeyad , Allen David ,   SLB, Allam Ahmed ,   SLB
Published: September 2024

Logging-while-drilling (LWD) nuclear magnetic resonance (NMR) tools play a crucial role in reservoir evaluation. However, in horizontal wells with thin layers smaller than the tool’s sensitive region, deciphering the contribution of each layer to the total signal poses a formidable challenge. The general thinking is that all the thin layers are contributing the same to the total acquired signal. However, the reality is more complex than just a box car response function. This complexity arises from the layer’s position relative to the cylindrical sensitive region, making it challenging to develop accurate forward models for LWD NMR tools in such scenarios. A theoretical response scheme was constructed to try to explain how the LWD NMR tools respond in such scenarios. However, conducting an experiment to validate the theory was a must to develop algorithms that can be used in forward modeling such complex response cases. To address this challenge, we designed and executed an experiment within a controlled environment—a water tank—that replicates the intricate conditions found in horizontal wells with thin beds. To overcome the practical limitations of measuring specific thin-bed characteristics at various positions in a laboratory, we used the calibration setup of the Slim-LWD NMR tool for measurement purposes. The experiment involved a systematic reduction of the water level in the calibration tank in discrete increments, emulating the vertical movement of a thin bed within the horizontal cylindrical sensitive region of the tool. Data acquisition was conducted at predefined intervals as the water level progressively decreased until the tank was empty. The noise level during this experiment is the standard 6 p.u. per phase alternated pair (PAP), and the final stacking level used is five levels. As the tool is stationary in this tank, no motion effects (axial or lateral) are encountered during the experiment. Through meticulous processing of the acquired water level data, we assessed the individual contribution of each level drop to the original signal. The culmination of this effort yielded a comprehensive lookup table containing the coefficients for horizontal layers as thin as 0.25 in. We believe that the outcome of this experiment can help log analysts have a better understanding of the LWD-NMR tool response in horizontal wells when more than one layer is measured at a single depth. As the experiment has validated the theoretical mathematical response we anticipated, a much thinner layer model can now be safely constructed with any layer thickness.
Piyasada Satılan Farklı Formlardaki Ganoderma lucidum Preparatlarında Antioksidan Kapasitenin Karşılaştırılması
Authors: Miser Salihoğlu Ece , Akkıran Selin
Published: September 2024

Ganoderma lucidum (Curtis) P. Karst. (Lingzhi veya Reyşi), Çin, Japonya ve diğer Asya ülkelerinde sağlığı ve uzun ömürlülüğü desteklemek için uzun bir kullanım geçmişine sahiptir. Kültür mantarları arasında, Reyşi, besin değerinden çok farmasötik değerinin önemli olması bakımından benzersizdir. Çay, diyet takviyeleri ve toz gibi çeşitli formlarda çeşitli ticari Reyşi ürünleri mevcuttur. Bunlar, meyve gövdesi, misel ve sporlar dahil olmak üzere mantarın farklı kısımlarından üretilmektedir. Reyşi'nin sağlık üzerinde yararları arasında kan glukoz seviyesininin kontrolü, bağışıklık sisteminin modülasyonu, hepatoproteksiyon, bakteriyostaz yer almaktadır. Mantarın farklı kısımlarından hazırlanan, basit tip, toz ve kapsül veya tablet şeklinde işlenen çok sayıda ürün şu anda piyasada bulunmaktadır ve ülkemizde de oldukça yaygın kullanılmaktadır. Çalışmamızda, Türkiye’de satılan farklı markalara ait Reyşi tabletlerinde ve toz formdaki çaylarında antioksidan aktivitenin karşılaştırılması ve incelenmesi DPPH, DMPD ve Folin Ciocalteu yöntemleri kullanılarak gerçekleştirilmiştir. Çalışmamızda elde ettiğimiz sonuçlara göre sulu mantar ekstrelerinden; N5, N1 ve N2 (259.8696 µg GAE/mL, 220.1594 µg GAE/mL, 185.6667 µg GAE/mL) yüksek, N3 ve N4 (80.01449 µg GAE/mL, 119.2899 µg GAE/mL) örneklerinin düşük fenolik içeriğe sahip olduğu görülmüştür. Antioksidan temizleme kapasitelerine bakıldığında ise örneklerin fenolik içerikleri ile yüzde temizleme kapasiteleri DMPD/EtOH, DMPD/su ve DPPH/EtOH paralel olarak bulunmuştur. IC50 değerleri DMPD sulu ekstreler için 0,155 mg/ml (N1), 1,704 mg/ml (N2), 7,453 mg/ml (N3), 6,570 mg/ml (N4), 2,223 mg/ml (N5); etanollü ekstreler için 0,138 mg/ml (N1),1,496 mg/ml (N2), 2,796 mg/ml (N3), 4,780 mg/ml (N4), 2,162 mg/ml (N5)’dir. DPPH sonuçlarının yüksek çıkması sebebiyle IC50 değerleri hesaplanamamıştır.
Kanserle Savaşta Doğal bir Güç: Tıbbi Mantarlardaki Hispolonun Anti-Kanser Etkileri
Authors: Pak Elif Nisa
Published: September 2024

Kanser ülkemizde ölüm nedenleri arasında ikinci sırada yer almaktadır ve dünya çapında önemli bir halk sağlığı sorunudur. Geçtiğimiz birkaç yıl içinde, özellikle besinlerden elde edilen doğal bileşikler birçok kanser önleyici ilaç ya da takviye olarak tanımlanmıştır. Fakat bunların çok azı ya ileri klinik deneylerdedir ya da terapötik kullanım için hâlihazırda onaylanmıştır. Hispolon, geleneksel olarak kanser tedavisi dâhil birçok hastalık tedavisinde kullanılan tıbbi mantar türlerinde karşımıza çıkan stirilpiron grubundan fenolik bir bileşiktir. Bu derlemede amacımız, hispolon bileşiğinin anti-kanser etkilerini ve bu etkilerin olası mekanizmalarını açıklamaktır. Biyoaktif doğal bileşik olan hispolonun, hücre döngüsünü durdurma, apoptotik, anti-proliferatif, tümör gerilemesi, anti-metastatik gibi mekanizmalar yoluyla anti-kanser etki gösterdiği bildirilmiştir. Hispolonla ilgili çalışmalar daha yeni ve mekanizmaları, toksisitesi tam olarak anlaşılmış değildir.
Ek olarak, nerdeyse tüm çalışmalar hücre düzeyindedir. Hispolonun, anti-kanser bir ilaç olarak ya da alternatif bir takviye olarak kullanımı için daha fazla klinik çalışmaya ihtiyaç vardır.
Amorf borun elektrokimyasal eksfoliasyonuyla borofen sentezi ve karakterizasyonu
Authors: Kuru Duygu
Published: September 2024

Bu çalışmanın amacı, amorf bor kullanılarak elektrokimyasal eksfoliyasyon yöntemiyle hızlı ve ölçeklenebilir borofen üretimidir. Elektrokimyasal eksfoliyasyon yönteminin hızlı, basit, ucuz, ölçeklenebilir ve yüksek verimliliği, borofenin büyük ölçekli ve ticari üretimi için bir fırsat sunabilir. Bu yöntemde amorf bor, sodyum sülfat (Na2SO4) ve gliserin karışımı kullanılarak iki elektrotlu bir düzenekte anodik olarak eksfoliye edilmiştir. Eksfoliyasyon, viskoziteyi arttırmak için gliserinin eklendiği (1:1 hacim oranı) 0,5 M Na2SO4 içerisinde +20, +30 ve +40 V’de gerçekleştirilmiştir. Borofenin yapısal karakterizasyonu Taramalı Elektron Mikroskobu (SEM), Yüksek Çözünürlüklü Geçirimli Elektron Mikroskobu (HRTEM), Fourier Dönüşümlü Kızılötesi Spektroskopisi (FT-IR), X-ışını Fotoelektron Spektrometresi (XPS), mikro-Raman, X-Ray Işınları difraktometresi (XRD) ve Atomik Kuvvet Mikroskobi (AFM) analizleri ile incelenmiştir. 20 V’de eksfoliye olan borofen katmanlarının ortalama kalınlığı 15,1 nm iken, 30 ve 40 V’de eksfoliyasyon sonucu olarak sırasıyla 15,3 ve 14,5 nm ortalama kalınlık değerleri elde edilmiştir. 20 V'de eksfoliye olan borofen katmanlarının yanal boyutu 319 nm'dir, bu boyut, 30 V (252 nm) ve 40 V'de (275 nm) eksfoliye olanlardan daha büyüktür. HRTEM görüntüleri birkaç borofen katmanının oluştuğunu göstermektedir. Farklı voltaj değerleri karşılaştırıldığında en etkili eksfoliyasyonun 20 V değerinde gerçekleştiğini ve bu değerdeki borofen katmanlarının nispeten daha düşük kalınlığa sahip olduğunu söylemek mümkündür.
Modified Satlin activation function for Deep Neural Networks
Authors: Бодянський Є. В. , Кулішова Н. Є. , Петрикін М. Ю.
Published: September 2024

Deep Neural Networks are widely used to solve a variety of practical problems: language processing, image and video recognition, and others. Such architectures include millions of elementary neurons, used activation functions. Their properties significantly affect the entire network results. The paper examines the problem of increasing Deep Neural Networks learning rate and accuracy through the use of variable shape activation functions, which parameters can be adjusted during network training. As a solution, a modified Satlin activation function is proposed. It has compressive properties, but does not contain asymptotic branches, protecting Deep Neural Network from a vanishing gradient.
Дослідження ефективності моделей згорткових нейронних мереж в задачах класифікації медичних зображень
Authors: Прочухан Д. В.
Published: September 2024

Проведено дослідження ефективності моделей згорткових нейронних мереж в задачах класифікації медичних зображень. Для подальшої обробки використано набір даних APTOS. Наведений набір даних містить 5 класів зображень. Для аугментації даних здійснено перевертання зображень, обертання випадковим чином в діапазоні від –20 до 20 градусів, зміщення по горизонталі в межах 20 % від загальної ширини, зміщення по вертикалі в межах 20 % від загальної висоти, збільшення та зменшення в діапазоні від 0,8 до 1,2 разів від оригінального розміру. В результаті проведеної аугментації кількість зображень всіх класів склала 1500. Для навчання використано 80 % зображень, для тестування 10 % зображень, для перевірки 10 % зображень. Розроблено нейромережеву модель, що дозволяє оцінити ефективність класифікації медичних зображень. Здійснено навчання згорткових нейронних мереж DenseNet-121, DenseNet-169, DenseNet‑201, ResNet-50, ResNet-101-V2, ResNet-152, InceptionV3, Inception ResNetV2, EfficeintNet-B7. Найкращий показник точності на навчальній множині отримано для моделі Densenet-169. Він склав 99,568 %. Найкращий показник точності на перевірочній множині отримано для моделі EfficientNet-B7. Він склав 90,691 %.
Розробка та дослідження алгоритмічної моделі для адаптивного управління конфігураціями програмних мікросервісів
Authors: Ткачук М. В. , Зінов’єв Д. В.
Published: September 2024

Розглянута актуальна науково-технічна задача адаптивного управління конфігураціями програмних застосунків з мікросервісною архітектурою (МСА). Проаналізовані деякі існуючі підходи до її вирішення і звернено увагу на складність таких програмних рішень і технологічних процесів, велику кількість параметрів опису та слабку здатність до формалізації їх взаємозв’язків. Зважаючи на це, замість застосування аналітичних моделей та методів запропоновано розробити алгоритмічну модель для визначення ефективних конфігурацій МСА, яка використовує методи логічного висновку на основі аналізу прецедентів (case-based reasoning – CBR). Розглянуті параметри опису проблемних ситуацій, визначені метрики для їх кількісної оцінки і запропоновано формальний опис алгоритмічної моделі для адаптивного управління конфігураціями МСА. Розроблена структурно-функціональна схема цієї моделі та виконана реалізація її програмного прототипу із застосуванням стеку технологій JavaScript (JS), Node.js і Serverless Framework, а також хмарних сервісів Amazon Web Services. Проведені обчислювальні експерименти з тестовою базою прецедентів, результати яких порівнювалися з альтернативними програмними рішеннями, зокрема, із застосуванням спеціальних засобів для реалізації відкритих CBR проектів, таких, як myCBR і jCOLIBRI. Аналіз цих результатів показав працездатність запропонованого підходу та його переваги для певних проблемних ситуацій, що дозволяє на (15–25) % скоротити час, потрібний для пошуку відповідного рішення у базі прецедентів системи.
Global evidence on the effectiveness and unintended health, social and economic consequences of public health and social measures during the COVID-19 pandemic: An Interactive Evidence Map of Existing Reviews
Authors: Fadlallah Racha , El-Jardali Fadi , Bou Karroum Lama , Kalach Nour , Hoteit Reem , Aoun Andrew , Al-Hakim Lara , Verdugo-Paiva Francisca , Rada Gabriel , Fretheim Atle , Lewin Simon , Ludolph* Ramona , A. Akl Elie
Published: September 2024

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Penggunaan media video Macromedia Flash 8 dalam pembelajaran matematika materi bangun ruang sisi datar
Authors: Taurintya Della , Untu Zainuddin , Berahman Berahman
Published: September 2024

Rendahnya hasil belajar pada materi geometri dapat dikarenakan sulitnya Siswa memahami pelajaran matematika. Kemajuan teknologi belum sepenuhnya dimanfaatkan oleh Guru dalam pembelajaran sehingga menyebabkan Siswa menjadi bosan dan jenuh. Dalam pembelajaran matematika, Guru banyak menggunakan metode satu arah. Penelitian ini bertujuan untuk mengetahui hasil belajar matematika Siswa setelah melakukan pembelajaran dengan menggunakan media video dan pembelajaran konvensional pada materi bangun ruang sisi datar di kelas VIII SMP Negeri 45 Samarinda. Penelitian ini merupakan penelitian kuantitatif deskriptif. Teknik pengumpulan data dalam bentuk tes dan observasi. Data hasil dari tes yang telah dilaksanakan kemudian dianalisis secara deskriptif meliputi rata-rata, standar deviasi, nilai maksimum, dan nilai minimum. Secara deskriptif, rata-rata untuk data hasil belajar matematika Siswa pada kelas yang menggunakan media video adalah 67 dengan nilai maksimum 94 sedangkan rata-rata kelas pada pembelajaran konvensional adalah 60 dengan nilai maksimum 82. Dapat disimpulkan bahwa hasil belajar pada kelas yang melakukan pembelajaran dengan menggunakan media video lebih tinggi dibandingkan hasil belajar dengan pembelajaran konvensional.
Effect of Behaviour Modification Strategies on Secondary School Students’ Classroom Misbehaviour
Authors: Aslam Shumaila , Farooq Prof.Dr. Muhammad Shahid
Published: September 2024

Misbehaviour in the classroom disrupts students' attention and negatively affects the teaching-learning process. Every learner has certain needs, and when these needs are not met at a critical moment, students start acting up in class. The best way to deal with a disruptive student is to take preventative measures. A causal comparative research design was used to examine the effect of teaching strategies on students’ classroom misbehaviour and find out the difference between male and female students’ perception about the classroom misbehaviors at secondary school level. The sample of the study was 408 students, selected by randomly from 34 public secondary schools in district Lahore. A self-developed instrument was used for data collection. The findings of the study show that students engage in misbehaviour i.e. skipping class, sleeping in the classroom, blaming the teaching method and cheating in tests/examinations.Teachers used strategies to deal with student misbehavior, including hand slapping, hitting with sticks, bending and slapping, and calling students names. There is a significant difference between male and female students’ perception about misbehaviors. Punitive strategies have a significant effect on students’ misbehaviours. Instructional and advisory committees should be established in schools to advise teachers on the psychological needs of students. Teachers should be introduced to innovative teaching strategies to deal with student misbehaviour. Different new courses may be included in the curriculum of pre- service teacher training programs.
PENDAMPINGAN MEMBANGUN LITERASI SEJARAH MELALUI HISTORY CLUB DI SMA CENDRAWASIH
Authors: Setyonugroho Ponco , Hidayat Fahmi , Fauzi Irfan Ahmad
Published: September 2024

Implementasi dari literasi sejarah menjadi jalan tengah dalam pembelajaran sejarah, pembelajaran sejarah menjadi menarik untuk peserta didik karena dalam pembahasannya tidak hanya menggunakan cara-cara lama seperti membaca artikel dan membaca buku, literasi sejarah menggunakan metode yang baru dalam menyebarluasan peristiwa sejarah baik menonton film, mendengarkan podcase ataupun membaca infografis. Hal ini terjadi karena adanya adanya gagasan untuk membuat wadah disekolah yang bernama Historical Club. Histori club dianggap mampu memberikan pemahaman lebih dari peserta didik karena wadah ini hadir diluar pembelajaran kelas, artinya ketika pendidik terbatas dalam penggunaan sumber dikelas karena waktu belajar 2x45 menit maka diluar kelas guru mampu memberikan pelajaran lebih dengan metode yang dirasa ampuh karena tidak terbatas dalam waktu dan ruangan. Adanya History Club tersebut dapat dikatakan penambahan materi tetapi dibalut dengan bermain, karena didalam History Club peserta didik bisa memilih dengan cara seperti apa bisa mendapatkan informasi sejarah. History Club menawarkan metode seperti menonton Film, Studi Museum dan menghadirkan sejarawan langsung kedalam proses pembelajaran dalam History Club. Padangan peserta didik mengenai sejarah sebelum adanya History Club sangat tidak menyukai sejarah karena guru tidak dapat memberikan suatu gambaran sejarah yang menarik guru hanya menjelaskan melalui PPT. Implementasi sumber sejarah dalam pelajaran sejarah mampu menjadi hal yang sangat menarik karena dengan menghadirkan sumber sejarah yang relevan mampu membangun Historical Thingking dan Historical Literacy peserta didik.
MENINGKATKAN SEMANGAT BERGOTONG ROYONG MELALUI MANCAKRIDA
Authors: Nisa Afiatin , Renata Dian , Utami Sri
Published: September 2024

Salah satu nilai yang ingin dikembangkan melalui profil pelajar pancasila yakni gotong royong. Semangat gotong royong merupakan perwujudan semangat kebangsaan yang harus dimiliki oleh peserta didik dalam keterkaitannya dengan kebijakan kurikulum merdeka. Melalui semangat gotong royong diharapkan peserta didik mampu mengembangkan pola interaksi yang positif dan dinamis dengan peserta didik lainnya. Hal ini tentu bertujuan agar semangat kebangsaan dan cinta tanah air serta semangat persahabatan pada diri peserta didik terus-menerus dikembangkan. Mancakrida merupakan salah satu sarana yang dianggap mampu mengembangkan semangat gotong royong tersebut. Melalui mancakrida diharapkan peserta didik mampu memunculkan semangat untuk menyelesaikan tugas yang diberikan secara bersama-sama sehingga cikal bakal gotong royong dapat dimunculkan. Niatan meningkatkan semangat bergotong royong ini dikemas dalam bentuk kegiatan pengabdian kepada masyarakat yang dilakukan di Madrasah Tsanawiyah Al-Hamid Kecamatan Cipayung Jakarta Timur. Kegiatan pengabdian ini dilakukan melalui tahap perencanaan, tahap kegiatan, dan tahap evaluasi dan tindak lanjut. Kegiatan diselenggarakan melalui metode ceramah serta pelaksanaan mancakrida. Hasil dari kegiatan ini adalah a) peserta mampu menumbuhkan semangat gotong royong melalui mancakrida, b) peserta antusias mengikuti kegiatan, dan c) direkomendasikan agar kegiatan serupa dilakukan dalam menumbuhkembangkan profil pelajar pancasila.
PKM PENYUSUNAN MODUL AJAR KURIKULUM MERDEKA DI SDN KENARI 01, KEC. SENEN, JAKARTA PUSAT
Authors: Aqil Deden Ibnu , Ramadona Mohammad , Kurniadi Fajar , Setiaji Dhani Harda
Published: September 2024

Perubahan kurikulum merupakan siklus yang harus dilaksanakan dalam system pendidikan nasional. Perubahan kurikulum memerlukan pengetahuan, sikap dan keterampilan untuk beradaptasi sesuai pedoman yang berlaku. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pengetahuan dan keterampilan kurikulum merdeka. Salah satu hal yang perlu diketahui dalam melaksanakan kurikulum Merdeka ini adalah Menyusun modul ajar. Dengan alasan tersebut tim pengabdian kepada masyarakat Universitas Indraprasta PGRI akan memberikan sosialiasi terkait pengetahuan, dan keterampilan Menyusun modul ajar kepada 50 orang guru di SDN 01 Kenari Jakarta Pusat.  Metode yang digunakan  dalam pelaksanaan kegiatan ini adalah diawali dengan pemberian pengetahuan tentang Sejarah dan perkembangan kuirkulum, literasi dan numerasi, pengembangan modul ajar yang dilanjutkan dengan praktek menyusun modul ajar, dan mempresentasikannya di depan audien. Adapun bentuk luaran yang diharapkan dari kegiatan ini adalah modul ajar kurikulum Merdeka sesuai dengan pedoman  dan  artikel publikasi pada jurnal nasional terindek sinta kemendikbud ristek.
PENGUATAN PROFIL PELAJAR PANCASILA MELALUI TOKOH SEJARAH ISLAM DI YAYASAN TANWIRUL AULADUL BALAD
Authors: Hudaya Adeng , Mansur Mansur , Suyana Nana , Bahrudin Bahrudin
Published: September 2024

ABSTRAKPelajar Pancasila murupakan wujud dari pelajar Indonesia yang sadar akan belajar sepanjang hayat, yang menyadari bahwa belajar sebagai kewajiban baik menurut islam maupun menurut undang-undang 1945 mengamanatkan kepada kepada pemimpin bangsa untuk mencerdaskan rakyat.  Perwujudan dari pelajar Pancasila mewajibkan pelajar memiliki kompetensi global dan berperilaku sesuai dengan nilai-nilai Pancasila, dengan enam ciri utama: beriman, bertakwa kepada Tuhan YME, dan berakhlak mulia, berkebinekaan global, bergotong royong, mandiri, bernalar kritis, dan kreatif. Pelajar Pancasila ini perlu diarahkan untuk semua jenjang Pendidikan baik formal maun non formal.  Tujuan pelaksanaan Abdimas ini adalah memberikan pencerahan dan penguatan nilai-nilai Pancasila kepada santri-santri dilingkungan Yayasan Tanwirul Auladul Balad. Metode dalam kegiatan Abdimas terbagi menjadi tiga tahap, 1) Pra-perencanaan: mengidentifikasi permasalahan yang ada di lingkungan mitra, memilih akar permasalahan lalu memberikan solusi 2) Perencanaan: membuat desain kegiatan berdasarkan hasil dari identifikasi permasalahan yang ada 3) Pelatihan: pemaparan materi yang disesuaikan dengan permasalahan yang akan diselesaikan,  dalam kegiatan ini dipilih materi tentang tokoh sejarah islam yang syarat akan nilai-nilai pancasila yaitu Muhammad Al-Fatih.
Performance evaluation of Bacopa monneri-loaded ethosomes for topical delivery
Authors: Dwivedi Deepti , Nimisha  , Mishra Neeraj , Singh S P , Shukla Alok Kumar
Published: September 2024

Bacopa monnieri is a plant with a rich history of use in traditional Ayurvedic medicine, spanning several centuries. It is also referred to as Brahmi in some regions. This product serves as a treatment for various skin conditions, such as inflammation and wound healing. Its properties also aid in the production of collagen and improve circulation. The inclusion of antioxidants enhances your skin's overall health, resulting in a rejuvenated and vibrant appearance. The present study aimed to prepare a nano-lipoidal system loaded with Bacopa monnieri (BM) extract and its characterization. Twelve formulations (F1-12) were developed using the ether injection method using different ratios of BM extract, L-alpha phosphatidylcholine (SPC), ethanol, and water. Bacoside A was used as a marker compound for estimation purposes. BM extract-loaded ethosomes were characterized in which formulation F-5 showed the highest entrapment efficiency of 89 %, with vesicle size 188 nm, while the zeta potential was -29.19 mV, and the polydispersity index (PDI) was  0.221±1.45. In vitro extract release using a dialysis membrane was performed for 12 hours, and it was found to be 44 % and 61 % at the end of 8 and 12 hours. The formulation followed zero-order non-Fickian diffusion kinetics, which is best for transdermal formulations. The goat skin was used for Confocal laser scanning microscopy (CLSM) study which showed the fluorescence intensity of Rhodamine B entrapped in those was 16.783, while it was 8.580 in the blank hydroethanolic solution, which confirmed the penetration of the ethosomal systems up to 30-40 µm deeper into the skin which gives a possibility that ethosomes can contribute in collagen synthesis and decrease the degradation of elastin in the deeper layers.
Novel class of antimicrobials from the marine isolates of actinomycetes and their potential screening against multidrug-resistant bacterial strains
Authors: Selvakumar Thanganadar Appapalam , Jayaraman Sanjana , Sundaresan Sudharshana , Kumar Naveen , Senthilkumar Krishnaveni
Published: September 2024

Microbial pathogenesis contributes a significant proportion to the global human mortality rate. Further, the outbreak of antimicrobial-resistant strains represents an alarming threat to human and animal healthcare, which drives scientific research on searching for novel antimicrobials. The present study is one such initiative to isolate new classes of antibiotics from the marine actinomycetes to combat the perpetual increase of multidrug-resistant strains. The soil samples from Tamil Nadu, India's coastal regions, were collected, and eight isolates of the actinomycete species (S1, S1b, S2, S3, S4b, S4W, S4R, S5) were recovered. From their 16S rRNA sequencing, the isolates belonged to Streptomyces sp.; the phylogenetic tree was constructed through the neighbour-joining method. Further, the secondary metabolites of all the isolates were screened against ATCC strains, Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Escherichia coli (ATCC 25927) and Acinetobacter baumanni (ATCC 19606) and multidrug-resistant (MDR) strains, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), carbapenem-resistant Klebsiella pneumonia (OXA) and colistin-cephalosporin resistant Escherichia coli (MCR). Of the eight isolates, S1b and S3 showed good inhibition for all the strains tested and their genomic sequences were sequenced and submitted to Genbank, MK641472 (S1b) & MK641473 (S3). Conclusively, their metabolites were purified using LC-MS and no resemblances were found with standard classes of antimicrobials such as nitrofurans, sulfonamides, fluoroquinolones, tetracyclines, chloramphenicols or ivermectins, which suggests that these metabolites are novel and could be exploited for the prospective antimicrobial research.
Barnyard millet: A crop of promise elucidated through correlation and path analysis
Authors: Sehrawat Anish , Singh Anoop , Sehrawat Krishan D , Sehrawat Anita Rani
Published: September 2024

With today's changing dietary demands and agricultural constraints, millets have become essential crops with significant agronomic and nutritional benefits. Among these, barnyard millet stands out for its resilience and nutritional richness. Despite its considerable nutritional and agronomic benefits, Barnyard millet suffers from a lack of recognition, relegating it to the status of a neglected and underutilized crop. The present study ventures into barnyard millet cultivation, utilizing correlation and path coefficient analysis to elucidate the complex interplay influencing its productivity and attributes. The study was conducted over two consecutive years and involved 172 genotypes with 23 yield-contributing traits under scrutiny. Panicle weight per plant (PWPP) (0.98), single panicle weight (0.81), biological yield per plant (0.79) and harvest index (0.71) exhibited strong positive correlations with grain yield per plant. While PWPP (0.82), PL (0.36), DSYPP (0.31) and HI (0.30) demonstrated high direct positive effects on grain yield per plant in the path coefficient analysis, emphasizing their significance in breeding programs. By improving these traits through selective breeding or genetic manipulation, researchers can potentially develop high-yielding varieties better adapted to varying environmental conditions. Conversely, days to maturity had a significant negative correlation with grain yield (-0.28) focusing on selecting early maturity genotypes. Panicle exertion (-0.30), biological yield per plant (-0.21) and flag leaf sheath length (-0.18) had the highest negative direct effects in the path analysis, suggesting their potential role as limiting factors in barnyard millet cultivation.  Overall, these findings provide a roadmap for future research endeavours aimed at enhancing the productivity and resilience of barnyard millet, ultimately contributing to food security and agricultural sustainability in regions where this crop plays a vital role.