bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel compound heterozygous variants in the CSPP1 gene causes Joubert syndrome: case report and literature review of the CSPP1 gene’s pathogenic mechanism
Authors: Wei Caichuan , Zhang Haiju , Fu Miaoying , Ye Jingping , Yao Baozhen
Published: March 2024

Joubert syndrome (JS) is a rare autosomal recessive neurodevelopmental condition characterized by congenital mid-hindbrain abnormalities and a variety of clinical manifestations. This article describes a case of Joubert syndrome type 21 with microcephaly, seizures, developmental delay and language regression, caused by a CSPP1 gene variant and examines the contributing variables. This paper advances the understanding of JS by summarizing the literature and offering detection patterns for practitioners with clinical suspicions of JS.
The interplay of maternal and offspring obesogenic diets: the impact on offspring metabolism and muscle mitochondria in an outbred mouse model
Authors: Xhonneux Inne , Marei Waleed F. A. , Meulders Ben , Andries Silke , Leroy Jo L. M. R.
Published: March 2024

Consumption of obesogenic (OB) diets increases the prevalence of maternal obesity worldwide, causing major psychological and social burdens in women. Obesity not only impacts the mother’s health and fertility but also elevates the risk of obesity and metabolic disorders in the offspring. Family lifestyle is mostly persistent through generations, possibly contributing to the growing prevalence of obesity. We hypothesized that offspring metabolic health is dependent on both maternal and offspring diet and their interaction. We also hypothesized that the sensitivity of the offspring to the diet may be influenced by the match or mismatch between offspring and maternal diets. To test these hypotheses, outbred Swiss mice were fed a control (C, 10% fat, 7% sugar, and n = 14) or OB diet (60% fat, 20% sugar, and n = 15) for 7 weeks and then mated with the same control males. Mice were maintained on the same corresponding diet during pregnancy and lactation, and the offspring were kept with their mothers until weaning. The study focused only on female offspring, which were equally distributed at weaning and fed C or OB diets for 7 weeks, resulting in four treatment groups: C-born offspring fed C or OB diets (C » C and C » OB) and OB-born offspring fed C or OB diets (OB » C and OB » OB). Adult offspring’s systemic blood profile (lipid and glucose metabolism) and muscle mitochondrial features were assessed. We confirmed that the offspring’s OB diet majorly impacted the offspring’s health by impairing the offspring’s serum glucose and lipid profiles, which are associated with abnormal muscle mitochondrial ultrastructure. Contrarily, maternal OB diet was associated with increased expression of mitochondrial complex markers and mitochondrial morphology in offspring muscle, but no additive effects of (increased sensitivity to) an offspring OB diet were observed in pups born to obese mothers. In contrast, their metabolic profile appeared to be healthier compared to those born to lean mothers and fed an OB diet. These results are in line with the thrifty phenotype hypothesis, suggesting that OB-born offspring are better adapted to an environment with high energy availability later in life. Thus, using a murine outbred model, we could not confirm that maternal obesogenic diets contribute to female familial obesity in the following generations.
Comparing genetic differentiation and variation using ISSR and SCoT among Juniper plant markers in Saudi Arabia
Authors: Al-Yasi Hatim M. , Al-Qthanin Rahmah
Published: March 2024

Juniperus, a genus of fragrant evergreen trees in the Cupressaceae family, encompasses up to 67 distinct species distributed globally. Among these, Juniperus procera, also known as the East African pencil cedar or African Juniper, stands out for its notable medicinal properties. Due to the well-recognized therapeutic benefits of Juniper species, assessing genetic diversity is essential for various breeding initiatives. Thus, in this work, six ISSR and six SCoT primers were utilized to evaluate the genetic diversity between 23 Juniper genotypes collected from different locations in Saudi Arabia. 29 out of 103 and 26 out of 105 amplified bands, respectively, were found to be polymorphic markers using the ISSR and SCoT studies. With the help of 120 genotype-specific markers, including 60 for ISSR and 60 for SCoT, several varieties of Juniper were discovered. In addition, the polymorphism information content (PIC) was computed to assess the effectiveness of the markers. The findings of this study highlight the importance of conserving the genetic diversity of Juniperus procera, as it holds immense potential for developing new medicinal products. Additionally, the results provide valuable insights into the genetic structure of Juniper populations in western Saudi Arabia, which can inform future conservation and management efforts. However, all of the techniques utilized to profile the genotypes of Juniper can be regarded as useful techniques for long-term fingerprinting and diagnostic markers.
Automated disassembly of e-waste—requirements on modeling of processes and product states
Authors: Saenz José , Felsch Torsten , Walter Christoph , König Tim , Poenicke Olaf , Bayrhammer Eric , Vorbröcker Mathias , Berndt Dirk , Elkmann Norbert , Arlinghaus Julia
Published: March 2024

Automated disassembly is increasingly in focus for Recycling, Re-use, and Remanufacturing (Re-X) activities. Trends in digitalization, in particular digital twin (DT) technologies and the digital product passport, as well as recently proposed European legislation such as the Net Zero and the Critical materials Acts will accelerate digitalization of product documentation and factory processes. In this contribution we look beyond these activities by discussing digital information for stakeholders at the Re-X segment of the value-chain. Furthermore, we present an approach to automated product disassembly based on different levels of available product information. The challenges for automated disassembly and the subsequent requirements on modeling of disassembly processes and product states for electronic waste are examined. The authors use a top-down (e.g., review of existing standards and process definitions) methodology to define an initial data model for disassembly processes. An additional bottom-up approach, whereby 5 exemplary electronics products were manually disassembled, was employed to analyze the efficacy of the initial data model and to offer improvements. This paper reports on our suggested informal data models for automatic electronics disassembly and the associated robotic skills.
Evil perceptions but not entertainment value appraisals relate to conspiracy beliefs
Authors: Harmon-Jones Eddie , Szymaniak Kinga , Edgeworth Dominic , Sebban Gabriel , Harmon-Jones Cindy
Published: March 2024

The current research examined whether the perception of evil intentions by the conspirators influences conspiracy beliefs about particular narratives. Study 1 manipulated texts describing the death of convicted sex offender Jeffrey Epstein to be either low or high in conspiratorial information. Studies 2 and 3 manipulated texts describing a fictional country's election to be either low or high in antagonism. The studies revealed that the conspiratorial/antagonistic texts increased evil perceptions and conspiracy beliefs. Moreover, they revealed that perceptions of evil mediated the effect of the text condition on conspiracy beliefs. Although the studies found that the conspiratorial/antagonistic texts increased entertainment value appraisals, they did not find evidence of entertainment value mediating the effect of text condition on conspiracy beliefs. These latter results do not replicate those of van Prooijen et al. (2022). The novel results with evil perceptions suggest that perceiving that the conspirators acted with evil intentions may increase conspiracy beliefs.
Overcoming barriers in the implementation of stroke care rehabilitation in a public hospital in Costa Rica
Authors: Coto-Solano Beatriz
Published: March 2024

Stroke is a major public health concern in developing countries, where the burden of the disease is high and resources for care are often limited. While progress has been made in improving stroke care, many barriers still exist in providing adequate rehabilitation care for stroke survivors. In this paper we study the case of Costa Rica and how stroke care has been addressed in recent years. It is important to consider the particularities of Costa Rica when working on stroke rehabilitation. The existence of a socialized healthcare system, along with the consolidation of acute stroke management protocols, allows for the adequate management of the early stages. In addition to this, families play a key role in rehabilitation, particularly for a country where there is a lack of medium stay and long-stay rehabilitation centers. Therefore, providing training and education for families is essential in stroke case management. Looking toward the future, there is still a pending need to generate homogeneous stroke rehabilitation protocols throughout the national healthcare system, to ensure equitable access to health care, and to consolidate multidisciplinary groups. At the same time, the implementation of technologies is urgent, particularly considering their potential to help reduce waiting lists. Another goal is enhancing coordination with other state entities and NGOs to advance community, labor or educational reintegration of stroke patients.
Early Childhood in Marginalized Roma Communities: Health Risks and Health Outcomes
Authors: Filakovska Bobakova Daniela , Dankulincova Veselska Zuzana
Published: March 2024

Objectives:

This study aims to compare selected early childhood health risks and health outcomes of children from marginalized Roma communities (MRCs) in Slovakia with those of the majority.

Methods:

We obtained cross-sectional data from mother-child dyads from the majority (N = 109) and MRCs (N = 143) via questionnaires and from medical records. Socioeconomic status, health risks and health outcomes were compared using chi-square and Mann-Whitney U tests in SPSS.

Results:

Mothers from MRCs reported significantly worse socioeconomic status. Air quality in the households in MRCs was significantly worse, affected by heating with stoves, burning fresh wood and indoor smoking. The diet composition of children from MRCs was characterized by shorter breastfeeding and unhealthy diet composition less fresh fruits and vegetables, more processed meat products, and sweet and salty snacks. Children from MRCs more often suffered from respiratory and diarrheal diseases, used antibiotics and were hospitalized.

Conclusion:

The health and healthy development of children living in MRCs is endangered by various poverty-related factors. Persistent differences in exposures and health in early childhood should be a priority goal of the state’s social and health policies.
Soluble Immune Checkpoint Molecules as Predictors of Efficacy in Immuno-Oncology Combination Therapy in Advanced Renal Cell Carcinoma
Authors: Ueda Kosuke , Uemura Keiichiro , Ito Naoki , Sakai Yuya , Ohnishi Satoshi , Suekane Hiroki , Kurose Hirofumi , Hiroshige Tasuku , Chikui Katsuaki , Nishihara Kiyoaki , Nakiri Makoto , Suekane Shigetaka , Ogasawara Sachiko , Yano Hirohisa , Igawa Tsukasa
Published: March 2024

Immuno-oncology (IO) combination therapy is the first-line treatment for advanced renal cell carcinoma (RCC). However, biomarkers for predicting the response to IO combination therapy are lacking. Here, we investigated the association between the expression of soluble immune checkpoint molecules and the therapeutic efficacy of IO combination therapy in advanced RCC. The expression of soluble programmed cell death-1 (sPD-1), soluble programmed cell death ligand-1 (sPD-L1), soluble PD-L2 (sPD-L2), and lymphocyte activation gene-3 (sLAG-3) was assessed in plasma samples from 42 patients with advanced RCC who received first-line IO combination therapy. All IMDC risk classifications were represented among the patients, including 14.3, 57.1, and 28.6% with favorable, intermediate, and poor risk, respectively. Univariate analysis revealed that prior nephrectomy, sPD-L2 levels, and sLAG-3 levels were significant factors affecting progression-free survival (PFS), whereas multivariate analyses suggested that sPD-L2 and sLAG-3 levels were independent prognostic factors for PFS. In a univariate analysis of the overall survival, prior nephrectomy and sPD-L2 levels were significant factors; no significant differences were observed in the multivariate analysis. No significant correlation was observed between the sPD-L2 and sLAG-3 levels and PD-L2 and LAG-3 expression via immunohistochemistry. In conclusion, sPD-L2 and sLAG-3 expression may serve as a potential biomarker for predicting IO combination therapy efficacy.
Derivation of the Langevin Equation from the Microcanonical Ensemble
Authors: Eichhorn Ralf
Published: March 2024

When writing down a Langevin equation for the time evolution of a “system” in contact with a thermal bath, one typically makes the implicit (and often tacit) assumption that the thermal environment is in equilibrium at all times. Here, we take this assumption as a starting point to formulate the problem of a system evolving in contact with a thermal bath from the perspective of the bath, which, since it is in equilibrium, can be described by the microcanonical ensemble. We show that the microcanonical ensemble of the bath, together with the Hamiltonian equations of motion for all the constituents of the bath and system together, give rise to a Langevin equation for the system evolution alone. The friction coefficient turns out to be given in terms of auto-correlation functions of the interaction forces between the bath particles and the system, and the Einstein relation is recovered. Moreover, the connection to the Fokker–Planck equation is established.
Modeling of Chemical Vapor Infiltration for Fiber-Reinforced Silicon Carbide Composites Using Meshless Method of Fundamental Solutions
Authors: Mahoney Patrick , Povitsky Alex
Published: March 2024

In this study, the Method of Fundamental Solutions (MFSs) is adopted to model Chemical Vapor Infiltration (CVI) in a fibrous preform. The preparation of dense fiber-reinforced silicon carbide composites is considered. The reaction flux at the solid surface is equal to the diffusion flux towards the surface. The Robin or third-type boundary condition is implemented into the MFS. From the fibers’ surface concentrations obtained by MFS, deposition rates are calculated, and the geometry is updated at each time step, modeling the pore filling over time. The MFS solution is verified by comparing the results to a known analytical solution for a simplified geometry of concentric cylinders with a concentration set at the outer cylinder and a reaction at the inner cylinder. MFS solutions are compared to published experimental data. Porosity transients are obtained by a combination of MFSs with surface deposition to show the relation between the initial and final porosities.
Marine-Derived Peptides with Anti-Hypertensive Properties: Prospects for Pharmaceuticals, Supplements, and Functional Food
Authors: Walquist Mari Johannessen , Eilertsen Karl-Erik , Elvevoll Edel Oddny , Jensen Ida-Johanne
Published: March 2024

Hypertension, a major health concern linked to heart disease and premature mortality, has prompted a search for alternative treatments due to side effects of existing medications. Sustainable harvesting of low-trophic marine organisms not only enhances food security but also provides a variety of bioactive molecules, including peptides. Despite comprising only a fraction of active natural compounds, peptides are ideal for drug development due to their size, stability, and resistance to degradation. Our review evaluates the anti-hypertensive properties of peptides and proteins derived from selected marine invertebrate phyla, examining the various methodologies used and their application in pharmaceuticals, supplements, and functional food. A considerable body of research exists on the anti-hypertensive effects of certain marine invertebrates, yet many species remain unexamined. The array of assessments methods, particularly for ACE inhibition, complicates the comparison of results. The dominance of in vitro and animal in vivo studies indicates a need for more clinical research in order to transition peptides into pharmaceuticals. Our findings lay the groundwork for further exploration of these promising marine invertebrates, emphasizing the need to balance scientific discovery and marine conservation for sustainable resource use.
Synthesis of Gold Clusters and Nanoparticles Using Cinnamon Extract—A Mechanism and Kinetics Study
Authors: Luty-Błocho Magdalena , Cyndrowska Jowita , Rutkowski Bogdan , Hessel Volker
Published: March 2024

In this work, UV-Vis spectrophotometry, High Resolution Scanning Transmission Electron Microscopes and selected experimental conditions were used to screen the colloidal system. The obtained results complement the established knowledge regarding the mechanism of nanoparticle formation. The process of gold nanoparticles formation involves a two-step reduction of Au ions to Au(0); atom association and metastable cluster formation; autocatalytic cluster growth; ultra-small particle formation (1–2 nm, in diameter); particle growth and larger particles formation; and further autocatalytic crystal growth (D > 100 nm). As a reductant of Au(III) ions, a cinnamon extract was used. It was confirmed that eugenol as one of the cinnamon extract compounds is responsible for fast Au(III) ion reduction, whereas cinnamaldehyde acts as a gold-particle stabilizer. Spectrophotometry studies were carried out to track kinetic traces of gold nanoparticle (D > 2 nm) formation in the colloidal solution. Using the Watzky—Finke model, the rate constants of nucleation and autocatalytic growth were determined. Moreover, the values of energy, enthalpy and entropy of activation for stages related to the process of nanoparticle formation (Index 1 relates to nucleation, and Index 2 relates to the growth) were determined and found to be E1 = 70.6 kJ, E2 = 19.6 kJ, ΔH1 = 67.9 kJ/mol, ΔH2 = 17 kJ/mol, ΔS1 = −76.2 J/(K·mol), ΔS2 = −204.2 J/(K·mol), respectively. In this work the limitation of each technique (spectrophotometry vs. HRSTEM) as a complex tool to understand the dynamic of the colloidal system was discussed.
Optimization and Application of the QuEChERS-UHPLC-QTOF-MS Method for the Determination of Broflanilide Residues in Agricultural Soils
Authors: Nie Xiaoli , Xie Guai , Huo Zhitao , Zhang Baoyu , Lu Haifei , Huang Yi , Li Xin , Dai Liangliang , Huang Siyuan , Yu Ailin
Published: March 2024

In this study, the separation conditions of UHPLC-QTOF-MS and the extraction conditions of QuEChERS were optimized. The analytical process for determining Broflanilide residues in different soil types was successfully established and applied to its adsorption, desorption, and leaching in soil. Broflanilide was extracted from soil with acetonitrile and purified using PSA and MgSO4. The modified UHPLC-QTOF-MS method was used for quantification. The average recovery of Broflanilide was between 87.7% and 94.38%, with the RSD lower than 7.6%. In the analysis of adsorption, desorption, and leaching quantities in four soil types, the RSD was less than 9.2%, showing good stability of the method, which can be applied to determine the residue of Broflanilide in different soils.
Inserted Religious Life as a Path to Authentic Consecrated Chastity—The Witness of Non-Violent Solidarity of Alice Domon and José Aldunate Lyon in Latin America 1967–1983
Authors: Azcuy Virginia Raquel
Published: March 2024

The reception of the Decree Perfectae caritatis in Latin America can be understood in connection with the emergence of the preferential option for the poor and the call for consecrated religious life to the insertion since the 1960s. As part of the existing link between conciliar texts and renewal movements, it is worth highlighting the testimony of religious life lived in solidarity with the poor as a way of practicing chastity and incorporating sexuality. This topic is explored through the life stories of two individuals, Alice Domon in Argentina (1937–1977) and José Aldunate Lyon in Chile (1917–2019), within the framework of related studies on ethnographic ecclesiology and the theology of renewed religious life. Amidst military governments, institutional violence, abuses of power, and human rights violations, the lives of these two consecrated individuals showcase an alternative path marked by self-emptying, unwavering fidelity, non-violent action, and prophetic denunciation. The pursuit of integration between contemplative and apostolic aspects in the love for God and the poor, along with the defense of human rights in solidarity with the victims and their families, are some of the keys that define an adapted understanding of religious life in the Latin American context.
Unicompartmental Knee Arthroplasty for Osteoarthritis Eliminates Lateral Thrust: Associations between Lateral Thrust Detected by Inertial Measurement Units and Clinical Outcomes
Authors: Sato Hikaru , Kijima Hiroaki , Iwami Takehiro , Tsukamoto Hiroaki , Saito Hidetomo , Kudo Daisuke , Kimura Ryota , Kasukawa Yuji , Miyakoshi Naohisa
Published: March 2024

The purpose of this study was to investigate the relationship between clinical outcomes and lateral thrust before and after unicompartmental knee arthroplasty (UKA) using inertial measurement sensor units. Eleven knees were evaluated with gait analysis. The varus angular velocity was used to evaluate lateral thrust. The femorotibial angle (FTA) and hip–knee–ankle angle (HKA) were used to evaluate lower-limb alignment, and the Oxford Knee Score (OKS) and Japanese Orthopaedic Association Score (JOA) were used to evaluate clinical outcomes. The mean pre-UKA peak varus velocity was 37.1 ± 9.8°/s, and that for post-UKA was 28.8 ± 9.1°/s (p = 0.00003), such that instabilities clearly improved. Assuming the definition of lateral thrust is when the varus angular velocity is more than 28.1°/s, 81.8% of patients had lateral thrust preoperatively, but this decreased to 55.6% postoperatively, such that the symptoms and objective findings improved. Both OKS and JOA improved after surgery. In addition, HKA was −7.9° preoperatively and −5.8° postoperatively (p = 0.024), and FTA was 181.4° preoperatively and 178.4° postoperatively (p = 0.012). There was a positive correlation between postoperative JOA and FTA, indicating that changes in postoperative alignment affected clinical outcomes. This study quantitatively evaluated the disappearance of lateral thrust by UKA, and it found that the stability can be achieved by UKA for unstable knees with lateral thrust.
End-to-End Emulation of LoRaWAN Architecture and Infrastructure in Complex Smart City Scenarios Exploiting Containers
Authors: Gaffurini Massimiliano , Flammini Alessandra , Ferrari Paolo , Fernandes Carvalho Dhiego , Godoy Eduardo Paciencia , Sisinni Emiliano
Published: March 2024

In a LoRaWAN network, the backend is generally distributed as Software as a Service (SaaS) based on container technology, and recently, a containerized version of the LoRaWAN node stack is also available. Exploiting the disaggregation of LoRaWAN components, this paper focuses on the emulation of complex end-to-end architecture and infrastructures for smart city scenarios, leveraging on lightweight virtualization technology. The fundamental metrics to gain insights and evaluate the scaling complexity of the emulated scenario are defined. Then, the methodology is applied to use cases taken from a real LoRaWAN application in a smart city with hundreds of nodes. As a result, the proposed approach based on containers allows for the following: (i) deployments of functionalities on diverse distributed hosts; (ii) the use of the very same SW running on real nodes; (iii) the simple configuration and management of the emulation process; (iv) affordable costs. Both premise and cloud servers are considered as emulation platforms to evaluate the resource request and emulation cost of the proposed approach. For instance, emulating one hour of an entire LoRaWAN network with hundreds of nodes requires very affordable hardware that, if realized with a cloud-based computing platform, may cost less than USD 1.
Topology Optimization Design Method for Acoustic Imaging Array of Power Equipment
Authors: Xiong Jun , Zha Xiaoming , Pei Xuekai , Zhou Wenjun
Published: March 2024

Acoustic imaging technology has the advantages of non-contact and intuitive positioning. It is suitable for the rapid positioning of defects such as the mechanical loosening, discharge, and DC bias of power equipment. However, the existing research lacks the optimization design of microphone array topology. The acoustic frequency domain characteristics of typical power equipment are elaborately sorted out. After that, the cut-off frequencies of acoustic imaging instruments are determined, to meet the needs of the full bandwidth test requirements. Through a simulation calculation, the circular array is demonstrated to be the optimal shape. And the design parameters affect the imaging performance of the array to varying degrees, indicating that it is difficult to obtain the optimal array topology by an exhaustive method. Aimed at the complex working conditions of power equipment, a topology optimization design method of an acoustic imaging array for power equipment is proposed, and the global optimal solution of microphone array topology is obtained. Compared with the original array, the imaging performance of the improved LF and HF array is promoted by 54% and 49%, respectively. Combined with the simulation analysis and laboratory test, it is verified that the improved array can not only accurately locate the single sound source but also accurately identify the main sound source from the interference of the contiguous sound source.
Adaptive Control for Virtual Synchronous Generator Parameters Based on Soft Actor Critic
Authors: Lu Chuang , Zhuan Xiangtao
Published: March 2024

This paper introduces a model-free optimization method based on reinforcement learning (RL) aimed at resolving the issues of active power and frequency oscillations present in a traditional virtual synchronous generator (VSG). The RL agent utilizes the active power and frequency response of the VSG as state information inputs and generates actions to adjust the virtual inertia and damping coefficients for an optimal response. Distinctively, this study incorporates a setting-time term into the reward function design, alongside power and frequency deviations, to avoid prolonged system transients due to over-optimization. The soft actor critic (SAC) algorithm is utilized to determine the optimal strategy. SAC, being model-free with fast convergence, avoids policy overestimation bias, thus achieving superior convergence results. Finally, the proposed method is validated through MATLAB/Simulink simulation. Compared to other approaches, this method more effectively suppresses oscillations in active power and frequency and significantly reduces the setting time.
Syntheses of Azulene Embedded Polycyclic Compounds
Authors: Razus Alexandru C.
Published: March 2024

This review focuses on obtaining embedded azulene polycyclic molecules treated according to their particular structure. The division of material into the azulene unit grafted only on one or two bonds and poly-fused azulene compounds was suggested with the intention of facilitating the presentation and assimilation of information. The similarity of some structural features in the compounds included in different analyzed classes results in the presence of the same synthesis protocol in several places. Obtaining benz[a]azulenes, azulene-fused acenes, and helicenes or azulene-embedded nanographene, along with other compounds, is presented.
PRACTICAL CLASSES AS A FORM OF COMPETITIVE PHARMACY SPECIALIST TRAINING
Authors: Sholoyko N.
Published: March 2024

In the article, in line with the tasks of forming the organizational and managerial culture of masters of pharmacy based on the concept of the development of the pharmaceutical industry as an integral component of the country’s health care system, the goal is realized. It is to clarify the role of practical classes as the leading organizational form of the educational process of training highly qualified personnel who develop and implements a modern system of ensuring the quality of medicinal products, has not only fundamental knowledge of physics, chemistry, biology, scientific management, special disciplines, but also has an extensive system of practical skills and professional activity skills.

On the basis of the general pedagogical principle of the unity of theory and practice, practical training is characterized as the leading organizational form of the educational process of professional training of pharmacy managers, which has its own objectives, intended for the development of students’ professional and practical skills necessary for specialists to perform their duties relationships and formation of professional and business qualities of graduates of the master’s level of education.

The works of Ukrainian scientists in terms of types, structure, methods of conducting, specifics of training teachers and students for practical classes of various forms and types are adapted to the needs of a specific field of specialist training.

It was concluded that the intensification of the educational process stimulates the use of advanced learning technologies accumulated by practice by teachers in practical classes. Practical classes are conducted using the elements of discussion, business game, "brainstorming", dyadic form of work of applicants (performance of tasks to consolidate the material in pairs, control of knowledge, evaluation of completed actions and tasks), etc. The summary of the results of a practical session with future pharmacists is often in the form of a colloquium, where the candidates announce their written results and briefly explain them. You can participate in the discussion of the proposed decision by expressing your opinion, motivating and arguing it.
DEVELOPMENT OF PROFESSIONAL CULTURE OF COLLEGE STUDENTS CULTURE AND ARTS WHEN STUDYING DISCIPLINES DECORATIVE AND APPLIED ARTS
Authors: Tetianin I. , Cherniavska O.
Published: March 2024

Analysis of culture as an anthropological phenomenon shows that culture is congruent with human beings. Historically, the cultural phenomenon has always reflected processes related to education, enlightenment, formation, and development of a person. Without education and training, without the active transmission of new achievements of human culture to new generations, the movement of history would be impossible. Therefore, the article updates the expediency of using profile subjects from the specialty «Decorative and Applied Arts» as a component of attracting first-year students of art educational institutions to the formation of their own professional culture.

The main art subjects and tasks (from simple to complex) are introduced into the educational context of future artist-decorative and applied arts teacher training are considered. Students are involved in working on the material together with the teacher. The student learns all the subtleties of mastery in practical work. In the mentioned direction, the concepts of «competence» and «mastery» are distinguished. It is stated that professional skill involves comprehensive knowledge of production or any other professional process, the ability to implement it, to set it in motion.

Since the development of culture and education are processes that are carried out mainly in parallel, synchronously, and interconnected, the essence of the meaning of the technology of situational learning (case method), which consists in modeling a specific situation that occurs in regional professional practice, has been clarified. Based on that, a didactic package of tasks for solving a certain issue is developed. The case method for first-year students is specific learning situations that are specially developed based on actual material for further study in classes.
ACTUAL ASPECTS OF MODERNIZATION OF PROFESSIONAL EDUCATION OF MILITARY PERSONNEL OF THE DEFENSE FORCES IN THE PERIOD OF MARTIAL LAW
Authors: Bukhun A.
Published: March 2024

The study updates the aspects of modernization of military education in Ukraine, which is determined by the military and political situation in the country, the need to increase the efficiency of the defense forces and the Armed Forces, reforming the national legislative framework for the professional training of military personnel in the context of joining the standards of the North Atlantic Treaty Organization (NATO).

The purpose of the article is to find out the social need for joint professional training of military personnel of the defense forces (the Armed Forces, law enforcement units, units of the State Border Service, the National Guard, the Security Service of Ukraine, etc.) and the possibilities of implementing its objectives by means of building integration models and technologies of the educational process.

The research has been conducted using the following theoretical methods: systematic analysis, comparison, induction and deduction, and usage of the methodological and theoretical tools of the competence-based scientific approach.

The following conclusions have been made: taking into account the integration processes of the field of military education in Ukraine, related to the liberation war and the country’s entry into the international security environment, the tasks caused by the modernization of the military education system are crucial. They must take into account the experience of a modern full-scale war, when the Armed Forces of Ukraine, the National the Guard of Ukraine and the State Border Service perform joint defense functions. It means that they need specialists who directly participate in defense and stabilization operations and have the appropriate professional competence.

At the same time, the lack of a united content system of professional military education and training, which contributes to the establishment of cooperation between the components of the defense forces within the framework of the implementation of tasks to ensure the defense of the state, is a particular problem. It has a negative impact on the interaction of the defense forces in the process of fulfilling the tasks provided for by the legislation. Therefore, the development of models of continuous education of military personnel for implementation by all law enforcement agencies in order to improve the quality of training of the social group of military professionals vital for the country is determined to be promising.
Perkawinan Beda Agama Pasca Keluarnya Surat Edaran Mahkamah Agung (SEMA) Nomor 2 Tahun 2023 Ditinjau dari Perspektif Maqashid Syariah
Authors: Khairina Safira Nafa , Hidayati Tri Wahyu
Published: March 2024

Konsep Maqashid Syariah untuk mewujudkan kemaslahatan harus tetap diperjuangkan dan diaplikasikan hingga saat ini, Meskipun teks Al-Quran telah berhenti namun permasalahan yang kita hadapi akan terus berkembang, maka Maqashid Syariah datang sebagai pintu untuk menyelesaikan masalah hukum-hukum Islam, Fenomena Perkawinan beda agama masih menjadi isu yang kontroversial dikarenakan terkabulnya permohonan perkawinan beda agama di Pengadilan Negeri Jakarta Pusat dalam putusan perkara nomor 155/Pdt.P/2023/PN.Jkt.Pst. Dengan demikian maka Mahkamah Agung mengeluarkan SEMA Nomor 2 Tahun 2023 yang ditujukan kepada Ketua/Kepala Pengadilan Tinggi Banding dan Ketua/Kepala Pengadilan Tingkat Pertama. Jenis penelitian ini  merupakan  penelitian  kualitatif  dengan pendekatan yuridis normatif yaitu menggali data dari aspek kepustakaan. Dengan dikeluarkanya SEMA No. 2 Tahun 2023 diharapkan dapat menjawab atas ketidakpastian hukum yang selama ini diresahkan masyarakat serta menjadi akhir dari polemik perkawinan beda agama dan diharapkan semua Hakim tunduk pada SEMA tersebut. Agar prinsip-prinsip maqashid syariah tetap terjaga.
Fatwa Tentang Kebakaran Hutan Dan Lahan Serta Pengendaliannya Dalam Perspektif Hukum Islam Dan Negara
Authors: Fadholi Yahya Muhajir , Nur Andini Mutya Octarisa , Asad Ali
Published: March 2024

Forests are an integral part of the life of the people who surround them. Living natural resources. Forests and land as gifts from Allah Swt are important to be maintained, preserved and used for the common good. Efforts to use community land and forests are often driven by burning, causing damage and loss. Forest and land fires are caused by 2 (two) general factors, namely natural factors and uncontrolled human activities. This study uses the understanding study method, namely data collection by searching books, magazines and online articles. The author seeks and collects data which is then collected and analyzed. The legal implication in the study of fiqh studies, ihya' al-mawat is that obtaining ownership rights to land is sought by ihya' al-mawat and applies to all types of land. However, in Indonesian law, land law is different from the reality, that is, there are separate rules for land management. During the dry season, especially during the extreme dry season because currently forest/land fires in Indonesia actually have several laws and regulations that are quite good at preventing forest and land fires for decades. However, all laws and regulations seem powerless to prevent karhutla from happening. Supervision and prosecution have proven to be a burden on the government and difficult to achieve optimally.
Analisis Wasiat Melalui Notaris Dalam Perspektif KHI dan Hukum Islam
Authors: Ni'am Khoirun
Published: March 2024

Penelitian ini dimaksudkan untuk menganalisis wasiat melalui Notaris dalam pandangan KHI dan Hukum Islam, dan mengkaji perbandingan dari keduanya di mana zaman dahulu memang belum mengenal Notaris sehingga masih banyak masyarakat yang berwasiat secara adat maupun secara syariat Islam baik dilakukan melalui ucapan maupun tulisan, yang mana wasiat tersebut sangat rawan terjadi gugatan, apalagi wasiat terkait masalah harta, sehingga dibutuhkan kekuatan hukum agar wasiat berjalan sesuai dengan harapan. Jenis Penelitian ini menggunakan jenis penelitian hukum normatif dengan menggunakan pendekatan perundang-undangan dan pendekatan konseptual. Sumber data yang digunakan adalah sumber data primer yaitu dari alquran, hadis, kitab pesantren, UUJN, Buku Kompilasi Hukum Islam, beberapa pasal KUH Perdata. dan sumber data tersier berupa jurnal-jurnal Hukum, dan juga buku-buku tentang Notaris, wasiat dan kewarisan Islam dengan teknik pengumpulan data pustaka. data dianalisis dengan metode analisis yang bersifat kualitatif dengan cara melakukan penafsiran terhadap sumber data yang telah diolah. Dengan metode penafsirannya menggunakan penafsiran perbandingan hukum. Hukum Islam dan KHI menyimpulkan bahwa Hukum berwasiat melalui Notaris bukanlah suatu kewajiban, tetapi hanya sebagai pilihan bagi seseorang yang akan berwasiat dan menjadikan wasiat sebuah akta autentik yang memiliki legalitas yang dapat digunakan untuk mengatasi gugatan–gugatan dari berbagai pihak karena kekuatan hukum yang dimiliki.
Pengaruh Komite Audit, Profitabilitas, Ukuran Perusahaan Terhadap Tax Avoidance
Authors: Rosyidah Selvi Diana , Nafif Faif , Jumaiyah Jumaiyah
Published: March 2024

Profit is the basis in determining the tax burden. Tax avoidance is an action to reduce tax obligations from the provisions of tax law. The purpose of this study is to examine and analyze the effect of the audit committee, profitability, and company size on tax avoidance in coal mining sector companies listed on the IDX for the 2016-2018 period. The type of research used is quantitative research. The data collection method used in this study is a documentation technique using the types and sources of secondary data. The analytical technique used in this research is multiple linear regression analysis. The sample selection used a purposive sampling method with a total sample of 39 coal mining sector companies listed on the IDX for the 2016-2018 period. The results of this study indicate that the audit committee calculated by the number of audit committees has no effect on tax avoidance. Profitability calculated by ROA has a significant negative effect on tax avoidance. Firm size calculated by Ln (Total Assets) also has no effect on tax avoidance.
Peran bank syariah dalam berbagai aspek bagi masyarakat Indonesia
Authors: Nissa Izzun Khoirun , Dhzuhri M.
Published: March 2024

The writing of this article reviews the role of Islamic banks for the people of Indonesia as the main subject of discussion. However, it does not only focus on one discussion, but matters relating to the role of Islamic banks in Indonesian society will be more or less conveyed. It aims to complement information related to the role of Islamic banks in Indonesia. It is certain that banks with basic sharia principles are needed by the people of Indonesia, the majority of which are Muslims. Not only that, the basic principles of Islamic banking, if dissected, will be more conscientiously liked by the Indonesian people in general, because the basis of justice, togetherness and mutual benefit are the basis for the implementation of service products in Islamic banks. Even if compared briefly with conventional banks , then it is as if conventional banks are superior in profit taking, but if studied in depth, Islamic banks will provide greater benefits. In terms of the religious and cultural aspects of Indonesian society, the basic principles of Islamic banking are more suitable than conventional banks. The elements of togetherness, justice and kinship that are thick with the Indonesian people are closely related to the basic principles of Islamic banking.
Strategi Prinsip Ekonomi Islam dalam Meningkatkan Ketahanan Ekonomi Keluarga Muslim Di Kabupaten Demak
Authors: Lia Sari Risti
Published: March 2024

This research aims to find out the principles of Islamic Economics in increasing the economic resilience of Muslim families in Demak Regensy and to find out what strategies the principles of Islamic Economics have in creasing the economic resilience of Muslim in Demak Regency. The Urgency or priority of this research was carried out in the hope that the Islamic Economic Principles strategy could help in increasing the economic resilience of Muslim families in Demak Regency. Tools / Intruments This research is a type of field research with qualitative research methods. The result of thisresearch are the principles of Islamic Economics in increasing the economic resilience of Muslim families in Demak Regency, including by balancing sources of incoming and asset ownership, estabilishing cooperation or syirkah, equitable social security, the role of government

Keywords : Islamic Economic,  Principles, family economic security
Faktor-Faktor Yang Mempengaruhi Konsumen Dalam Mengambil Keputusan Jual Beli Emas Di Kalinyamatan Jepara Dalam Perspektif Islam
Authors: ANWARUSSAID  , Susilo Edi , Aminnudin Moch
Published: March 2024

Masyarakat Kalinyamatan Jepara dominan beragama islam. Sebagai seorang muslim, hendaknya dalam melakukan kegiatan transaksi jual beli perlu dilandasi perilaku yang baik sesuai dengan ajaran Islam. Penelitian ini bertujuan untuk menguji adanya faktor faktor yang mempengaruhi konsumen dalam pengambilan keputusan jual beli emas di Kalinyamatan Jepara. Penelitian ini merupakan penelitian kuantitatif deskkriptif. Populasi dalam penelitian ini adalah masyarakat Kalinyamatan Jepara yang melakukan transaksi jual beli emas dan sampel yang diambil sebanyak 100 responden dengan menggunakan teknik simple random sampling. Metode pengumpulan data melalui penyebaran kuesioner. Teknik analisis data menggunakan regresi berganda dengan bantuan analisis menggunakan program SPSS versi 25.

Variabel independen dalam penelitian ini adalah perilaku konsumen (X1), jual beli (X2), dan faktor pengambilan keputusan (X3) variabel dependen pengambilan keputusan (Y). Hasil dari penelitian ini dapat disimpulkan bahwa secara parsial hanya perilaku konsumen yang berpengaruh signifikan terhadap perilaku pedagang dengannilai thitung sebesar 1,966 dan nilai probabilitas signifikansi 0.050, sedangkan jual beli dan faktor prngambilan keputusan tidak berpengaruh signifikan terhadap pengambilan keputusan. Kemudian berdasarkan Uji F perilaku konsumen, jual beli, faktor pengambilan keputusan secara simultan (bersama-sama) berpengaruh signifikan terahadap variabel pengambilan keputusan.
L’espace analytique des groupes thérapeutiques
Authors: Lucas Pierre
Published: March 2024

El espacio analitico en los grupos terapeuticos.

El lugar del analista esta en estrecha relacion con la especificidad de los grupos. Particularmente, este no puede ser percibido y comprendido sino es en relacion con todo lo que constituye el encuadre.

El proyecto aqui es relativamente limitado : saber si el concepto de “espacio analitico” elaborado por S. Viderman como fundamental para la cura puede aclararnos sobre el trabajo del grupo como trabajo psicoanalitico. Este concepto aparece como vinculado al espacio psiquico e igualmente a los dispositivos y modos de funcionamiento, es decir al encuadre.

En cuanto al grupo, el proyecto terapeutico y la preocupacion psicoanalitico nos ha conducido a releer la introduccion de “Psicologia de las masas y analisis del yo” desde un angulo particular. El encuadre del grupo del cual hablamos aquí, nos apareció como un punto culminante del cuar la mirada podia ir, ya hacia todos los fenomenos que nos la muestran como una pequeña maso, ya hacia lo que parece constituir un circulo limitado de la primeras relaciones, tales como las que coda uno esta acostumbrado a encontrar.
Le destin de représentations buts
Authors: Levental Jean-Yves
Published: March 2024

La possibilité de représentation sur la scène de psychodrame implique le niveau de convergence des préoccupations de chaque individu et la «poussée» respective des membres pour amener et interroger ces préoccupations dans le groupe. Plusieurs étapes se dessinent :

— chaque individu se soumet à un travail de promotion de représentation dans son intra-psychisme ;

— il conduit ses représentations dans le groupe, il s’en fait le «représentant » ;

— le groupe réagit selon divers degrés de tolérance vis-à-vis de la ou des personnes représentantes et des idées qu’elles apportent.

Pour aborder ces dimensions, j’ai choisi certaines moments de psychodrame dans des groupes qui comptent des patients psychotiques. C’est dans le sens où je pose l’effectivité de la représentation dans ses relais de l'intra-individuel à l'intra-groupal que je m’autorise à peindre ces moments groupaux comme autant de dispositions d’une entité psychique.
Les archétypes de la famille et les espaces de l’inconscient
Authors: Miermont Jacques
Published: March 2024

Los arquetipos de la familia y los espacios del inconsciente.

Las relaciones entre procesos conscientes e inconscientes seron debatidas a la luz de los desarrollos teoricos y pragmaticos contemporaneos :

En el regis tro teorico, despues de los modelos ciberbeticos, respuestas nuevas han sido aportadas por las investigaciones sobre la auto-referencia (G. Spencer-Brown, F. Varela), y por los modelos topologicos y catastroficos (E. C. Zeeman, R. Thom, J. Petitot).

En el registro de cierto control experimental en ciencias humanas, los diferentes abordajes de la terapia familiar demuestran los efectos de la pragmatica de las communicaciones sobre las estructuraciones psiquicas, y la importancia de las implicaciones e imbricaciones multipersonales, individuates y colectivas, tanto materiales como ficticias en dichas estructuraciones.

A la luz de las teorias de R. Thom sobre la morphogenese, proponemos una tentativa de considerar la existencia de formas familiares arqui-grupales, inconscientes qui estabilizan para el nino y mas tarde para el adulto el sentido de las palabras, de los afectos, de las esperiencias. Inversamente dificultades de estructuracion de las morfologias familiares pueden desestabilisar las adquisiciones semanticas.