bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic association of starvation-induced genes in head and neck cancer
Authors: Hamada Masakazu , Inaba Hiroaki , Nishiyama Kyoko , Yoshida Sho , Yoshiaki Yura , Matsumoto-Nakano Michiyo , Uzawa Narikazu
Published: April 2021

Autophagy-related genes (ARGs) have been implicated in the initiation and progression of malignant tumor promotion. To investigate the dynamics of expression of genes, including ARGs, head and neck squamous cell carcinoma (HNSCC) cells were placed under serum-free conditions to induce growth retardation and autophagy, and these starved cells were subjected to transcriptome analysis. Among the 21 starvation-induced genes (SIGs) located in the autophagy, cell proliferation, and survival signaling pathways, we identified SIGs that showed prominent up-regulation or down-regulation. These included AGR2, BST2, CALR, CD22, DDIT3, FOXA2, HSPA5, PIWIL4, PYCR1, SGK3, and TRIB3. The Cancer Genome Atlas (TCGA) database of HNSCC patients was used to examine the expression of up-regulated genes, and CALR, HSPA5, and TRIB3 were highly expressed relative to solid normal tissue in cancer and the survival rate was found to be reduced in patients with high expression. Protein-protein interaction analysis demonstrated the formation of a dense network of these genes. Cox regression analysis revealed that high expression of CALR, HSPA5, and TRIB3 was associated with poor prognosis in patients with TCGA-HNSCC. Therefore, these SIGs up-regulated under serum starvation may be molecular prognostic markers in HNSCC patients.
Simulating Heat Stress of Coal Gangue Spontaneous Combustion on Vegetation Using Alfalfa Leaf Water Content Spectral Features as Indicators
Authors: Wang Qiyuan , Zhao Yanling , Yang Feifei , Liu Tao , Xiao Wu , Sun Haiyuan
Published: April 2021

Background: Vegetation heat-stress assessment in the reclamation areas of coal gangue dumps is of great significance in controlling spontaneous combustion. Methods: The study simulated the heat-stress environment of a coal gangue dump reclamation area through a temperature gradient experiment. We collected leaf spectrum and water content data on alfalfa plants commonly planted in such areas. We then obtained the optimal spectral features of appropriate leaf water content indicators through time series analysis, correlation analysis, and least absolute shrinkage operator (lasso) regression analysis. A spectral feature-based long short-term memory (SF-LSTM) model is proposed to estimate alfalfa's heat stress level. Results: Comparing three leaf water content indicators, we found that the live fuel moisture content (LFMC) varies significantly with time and has high regularity. Correlation analysis of the raw spectrum, first-derivative spectrum, vegetation indexes and leaf water content data shows that LFMC and spectral data were the most strongly correlated. Combined with lasso regression analysis, the optimal spectral features were the first-derivative spectral value at 1661 nm (abbreviated as FDS (1661)), RVI (1525, 1771), DVI (1412, 740) and NDVI (1447,1803). When the classification strategies were divided into three categories and the time sequence length of the spectral features was set to five consecutive monitoring dates, the SF-LSTM model had the highest accuracy in estimating the heat stress level in alfalfa. The accuracy of the training set was > 95% and the accuracy of the verification set was about 90%. Conclusion: The results provide an important theoretical basis and technical support for vegetation heat-stress assessment in coal gangue dump reclamation areas.
Test-Retest reliability of prepulse inhibition (PPI) and PPI correlation with working memory
Authors: Freudenberg Florian , Althen Heike , Falk Kim , Bittner Robert A. , Reif Andreas , Plichta Michael M.
Published: April 2021

Sensorimotor gating – a mechanism to filter sensory input and regulate motor output - is experimentally operationalized by the prepulse inhibition (PPI) of the startle response (SR). Previous studies suggest high test-retest reliability of PPI and potential correlation with working memory (WM). Here we aimed to validate the test-retest reliability of PPI in healthy humans and its correlation with working memory (WM) performance. We applied an acoustic startle PPI paradigm with four different prepulse intensities (64, 68, 72, and 76 dB) and two different WM tasks (n-back, change detection task [CDT]). We were able to confirm high retest-reliability of the PPI with a mean intraclass correlation (ICC) of >0.80 and significant positive correlation of PPI with n-back but not with CDT performance. Detailed analysis showed that PPI across all prepulse intensities significantly correlated with both the 2-back and 0-back conditions, suggesting regulation by cross-conditional processes (e.g. attention). However, when removing the 0-back component from the 2-back data, we found a specific and significant correlation with WM for the 76 dB PPI condition. With the present study we were able to confirm the high test-retest reliability of the PPI in humans and could validate and expand on its correlation with WM performance.
Short-term storage of seeds and cryopreservation of embryonic axes of Lepisanthes fruticosa
Authors: Bustam Suryanti , Ali Mohd Shukri Mat , Sinniah Uma Rani , Shamsuddin Nur Atisha , Kadir Abdul Muhaimin Abdul
Published: April 2021

This work highlights short-term storage of recalcitrant Lepisanthes fruticosa seeds and long-term conservation attempts of its embryonic axes (EAs) through cryopreservation. Short-term storage was carried out using fresh seeds at 54 % moisture content and stored at 8 ±1 °C and 25 ±2 °C for 7 weeks. Three variations to sterilization were attempted to optimize survival while keeping contamination low for cryopreservation. Cryopreservation using two different methods were tested, namely vitrification and the encapsulation vitrification method. Vitrification technique involved the pre-culturing of EAs overnight in different sucrose pre-culture concentrations (0, 0.2, 0.4 and 0.6 M) prior to, loading, dehydration with plant vitrification solution (PVS2), rapid immersion into liquid nitrogen (-196 °C), rapid warming, unloading and recovery. While, encapsulation vitrification involved encapsulation of the EAs using 3 % sodium alginate followed by exposure to different duration (0, 10, 20, 30, 40 and 50 minutes) of PVS2 prior to cryopreservation. L. fruticosa seeds can be safely stored for short-term with no loss in germination up to 7 weeks of storage either at 8 ±1 °C or 25 ±2 °C. This study also showed that EA of L. fruticosa was amenable to cryopreservation, 13.0 – 66.67% of viability was obtained when the EAs were cryopreserved using the vitrification technique while the best result was obtained (66.67 % viability) when the EAs were pre-cultured with 0.4 M sucrose prior to exposure to PVS2 and liquid nitrogen. Cryopreservation of EAs using the encapsulation-vitrification method was unsuccessful.
Identifying the domains and factors influencing perceived Quality of Life (QoL) of Indian elderly in the context of their neighbourhoods: a case study of Kolkata, India
Authors: Saha Suparna , Basu Sanghamitra , Pandit Debapratim
Published: April 2021

The concept of Quality of Life (QoL) is multi-dimensional and has been explored from varied perspectives. Though QoL is a multi-dimensional concept, research on QoL has been mostly explored from a limited set of aspects. The assessment of QoL of elderly have been so far mostly based on measurement models derived from the perspective of American or European elderly. The subjectivity of the concept of QoL and the distinct dissimilarities in the perspectives of the elderly living in South Asian countries seeks for the development of QoL models from their perspective. Besides, since a significant number of the elderly in South Asian countries prefer to age-in-place, the need to identify parameters to improve their QoL in their neighbourhood context also becomes important. This paper, explores the perspectives of a group of Indian elderly, and identifies a broad set of domains and their respective set of factors, influencing perceived QoL of Indian elderly, which can be supported through the residential environment. The factors have been identified through literature review, followed by qualitative analysis of focus group discussions and quantitative analysis of close-ended interviews with Indian elderly across varied socio-demographic backgrounds. The present study, identifies seven broad domains and 37 QoL factors influencing perceived QoL of Indian elderly.
Executive Functions and Developmental Profiles in Preschool Children with Autism Spectrum Disorder
Authors: Memisevic Haris , Pasalic Arnela
Published: April 2021

Executive functions (EF) play a crucial role in overall human functioning. Children with Autism Spectrum Disorder (ASD) often have EF deficits. The goal of this study was to examine EF and developmental domains in preschool children with ASD. The sample for this study comprised 32 children (27 boys, mean age 65.3 months, SD- 4.0 months) with ASD. The control group consisted of 32 typically developing children (16 boys, mean age 64.3 months, SD- 5.1 months). EF were assessed with Behavior Rating Inventory of Executive Function and developmental domains were assessed with the Developmental Assessment of Young Children. The results of this study indicated that children with ASD do not have uneven EF and developmental profiles, although the EF and developmental domains scores were more heterogeneous than in typically developing children. Children with ASD had substantially lower EF and developmental scores than typically developing children. Implications of these results are discussed.
POTENTIAL POSSIBILITIES OF KHALKHIN-GOL REGION IN THE DEVELOPMENT OF INTERNATIONAL TOURISM
Authors:   Institute of International Affairs, Academy of Science Mongolia, Demberel K.
Published: April 2021

The relevance is primarily due to the fact that the development of trans-border territories is becoming an important tool for successful regional cooperation between Mongolia and its neighbouring countries. In these circumstances, it is necessary to study and understand the functions and mechanisms of cross-border cooperation, which will reveal the difficulties that exist there today. Within the framework of trilateral cooperation, including in the field of economic relations, our states attention to the development of border areas naturally increases. The object of the study is the cross-border tourism cooperation between Mongolia, the Russian Federation, and the People’s Republic of China. The article is devoted to the analysis of mongolian-russian-chinese relations at the present time. The subject is about the ways, forms and mechanisms of regional tourism cooperation between the three countries, as well as the factors that hinder this process. The purpose and objectives of the article is to analyze the main directions of cross-border cooperation between Mongolia, Russia and China in the trade, economic and tourism sector on the example of the border areas of our countries; to show what opportunities we have that we are losing and the challenges that border regions to interact in a more effective and mutually beneficial. There have been used general scientific empirical and theoretical research methods. The usage of a comparative-functional, systematic approach, modeling and a logical method encourages to identify the essential and substantive elements of the regional cooperation of the Mongolia, Russian Federation and China. The Chinese side is more business like about this problem, the Mongolian side is only in the study stage, and the Russian side has not yet shown any initiative. Research shows that Chinese tourists are interested in visiting the Mongolian steppe and to Russia. This research shows that Chinese tourists are interested in exploring/seeing Russia and Mongolian steppe. Therefore, Khalkhgol somon is a region that can develop cross-border tourism within the framework of the “One Region-One Road” project of the People’s Republic of China. This study shows that there is an opportunity to turn this region into a cross-border tourism region involving certain entities from the three countries
ANALYSIS OF THE MODERN POLITICAL PARTIES’ FUNCTIONALITY IN RUSSIA
Authors:   Transbaikal State University, Zimina N.
Published: April 2021

Modern political parties and their regional branches become an integral part of the political system of society, an important participant in public administration. They have their own organizational and legal basis, have their own charter, program, leaders, their own goals and objectives, and perform certain functions. One of the goals of any political party is to participate in the political life of society, in solving its issues. One of the party’s tasks is to participate in public administration, as a means of representing the interests of the population during elections at various levels and in the inter-election period. Political parties are a political institution and represent the ideological, conceptual, personnel and electoral resources of any government. The analysis of the political parties’ functionality shows how dynamic they are and how they follow their statutory goals and objectives. In this context, the research interest is the political parties’ functionality in the regional political process in the light of the changing legal field. The adopted amendments to the federal legislation on elections and on political parties have radically changed a number of conditions governing the procedure for the establishment and functioning of political parties and their regional branches in the regional dimension. The amendments made to the federal law “On Political Parties” have changed the conditions for the creation and operation of political parties, in particular, the minimum number of members of a political party when it is created has been reduced to 500 members; the approaches to voting have been changed. These changes correspond to the state of the modern political process and are aimed at the development of political institutions, including political parties
Evolution of the concept “regional security” in the world political science
Authors:   Transbaikal State University, Romanova N. , Kononov S. ,   Far Eastern Higher Combined Arms Command School named after Marshal of the Soviet Union K. K. Rokossovsky, Zhukov А. ,   Transbaikal State University, Zhukova А. ,   Transbaikal State University
Published: April 2021

The relevance of the article is due to the growing importance of the regional security factor in modern conditions, where the level of regional self-awareness and the desire for relative autonomy are growing within the framework of the general process of developing the security system. The article is devoted to the analysis of the security concepts existing in the history of political doctrines in order to identify the evolution of ideas about “regional security”. The study uses comparative, systemic and hermeneutic methods, the action of which is aimed at identifying aspects of regional security in the texts devoted to the problems of state, national and public security. The novelty of the research is associated with the development of the ideas’ evolution about regional security from abstract ideas to various aspects of regional practice. The result of the study is the evidence that, being originally one of the aspects of general management theory, the ideas of regional security at the end of the twentieth century have become the core of the concept of “regional security complexes”. The next result was the substantiation that modern criticism of this concept is the basis of the theoretical constructions of regional security in the 21st century, which are based on a synthesis of ideas about the need to adopt rules adopted by states that support the stability of world security and the influence of regions with their own interests. The conclusion of the study is to assert that modern concepts of regional security are based on the synthesis of methodologies of the systemic and constructivist approaches. This methodology is used to substantiate the assertion that any state is forced to deal with the security problems of its regions, to pay attention to the existing threats and regional interests in them, which may be of a constructive nature, and may pose a real danger associated with challenges from the political, economic, military, environmental, social spheres
CONCEPTUALIZATION OF SOCIAL SECURITY OF THE REGION IN THE CONTEXT OF POLITICAL REGIONALISM AND PHILOSOPHICAL DISCOURSE
Authors:   Transbaikal State University, Romanova N. , Kononov S. ,   Far Eastern Higher Combined Arms Command School named after Marshal of the Soviet Union K.K. Rokossovsky, Shevchenko М. ,   Transbaikal State University, Shevchenko Yu. ,   Transbaikal State University
Published: April 2021

The article is devoted to the development of a social security model in the region, representing a comprehensive vision of various aspects of interaction between man and society on the way to preserve social security. The aim of the study is an attempt to synthesize the provisions of various scientific and socio-philosophical concepts of social security with the provisions of regional studies into a single systemic model of social security in the region. The implementation of this goal is carried out by the authors using a methodology based on a civilizational approach, which asserts the uniqueness of each of the regions, a systematic approach that reveals the social system of a region as a multi-core phenomenon in which various social levels are distinguished; a structuralist approach, which proves that social conditions for safe life depend on the development and organization of the social environment; semiotic approach aimed at analyzing the region as a spatial, locally distinguished social system formed around a complex of regional values; an instrumental approach that pays attention to the impact of mechanisms leading to the regional interests’ mobilization. The novelty of the presented research is associated with a model development of social security of the region based on the principle of complementarity of philosophical concepts of social security and the provisions of regional studies. The result of the study is a statement of the impossibility of covering this phenomenon in models developed in individual sciences that form scattered images of the social security of the region, but do not cover the entirety of this phenomenon. The second result of the study is the formation of a social security model of the region, which allows taking into account civilizational, systemic, structural, value, instrumentally constructed parameters. The third result is the proof of the possibility of building a social security system based on values, the mobilization of which takes place within the framework of a dialogue between external and intra-regional social discourses
Inclusão Digital para adultos: Relato de experiência
Authors: GARCIA Fernanda Corrêa , GOMES Diego Ramos , COSTA Felipe Schneider , SILVA Rebeca  Guedes Maria da
Published: April 2021

Resumo: Este artigo apresenta o relato de experiência do projeto de extensão Inclusão Digital para Adultos. O projeto teve como objetivo principal desenvolver a inclusão digital do educando, fazendo com que após sua inserção no mundo digital ele possa interagir com esse novo paradigma social, sentindo-se valorizado como indivíduo, realizando-se como profissional, contribuindo assim para a melhoria de seu contexto social, de acordo com a formação obtida por meio das oficinas práticas. O projeto desenvolveu, por meio de oficinas educativas e práticas, a inclusão do público específico a ser atendido, contribuindo assim para a aproximação da comunidade externa com o Instituto Federal de Santa Catarina - campus Tubarão. Ao final do projeto conclui-se que os objetivos foram alcançados. No total, foram atendidos 30 alunos.
The Design of Remote Control System Based on the Embedded Web Server
Authors: Shuping Xu , Hongqing Yue , Fan Yang , Yajuan Wan
Published: April 2021

In order to expedite the development of the control network, according to the newest fruition of the internet, the hardware and software of the system is designed. Since the resource of the sever in embedded remote control system is limited, an approach is presented which use CGI and XML technology to realize remote monitoring computer and embedded Web server for dynamic interaction. Combined with the basic requirements of embedded remote control system, the idea of component design is proposed, the major components of system functions are defined. According to the system functional requirement, the software is designed and realized. The practice prove, the scheme realize the remote control of the transmitter by the small cost. And the system is convenient and safe. The definite reference value is offered to the offspring complex remote control system.
ZZAP treatment of red blood cells
Authors: Marckwardt S.I.
Published: April 2021

ZZAP is a mixture of a sulfhydryl reagent (dithiothreitol) and a proteolytic enzyme (papain or ficin). This reagent dissociates IgG and complement from red blood cells, allowing for phenotyping, enhanced adsorption, or denaturing of multiple blood group system antigens to aid in completing complex antibody workups. ZZAP treatment destroys all antigens in the Kell, Landsteiner-Wiener, Cartwright, Dombrock, and Knops blood group systems as well as antigens destroyed by proteases (e.g., M, N, S, Fya, and Fyb).
An update on the Knops blood group system
Authors: Moulds J.M.
Published: April 2021

This update of the Knops (KN) blood group system (Moulds JM. The Knops blood group system. Immunohematology 2010;26:2–7) adds no new antigens to this system (International Society of Blood Transfusion system 22), which currently has nine antigens. However, the molecular basis of York, KN5, or Yka has been identified as c.4223C>T and designated KN*01.-05. Although not considered clinically significant in the field of transfusion medicine, there has been great interest in the Knops polymorphism by investigators working on malaria documented by numerous studies over the past 8 years.
An update on the Lutheran blood group system
Authors: Daniels G.
Published: April 2021

This update of the Lutheran (LU) blood group system (Daniels G. Lutheran. Immunohematology 2009;25:152–9) describes six new antigens of the Lutheran system (International Society of Blood Transfusion system 5). These antigens are numbered LU22 to LU27, resulting in a total of 25 antigens in the system. The molecular background of LU7 is also described. New KLF1 mutations responsible for In(Lu) have been identified, and the gene responsible for the X-linked form of Lumod has been identified.
Cryogenic heat capacity measurements and thermodynamic analysis of lithium aluminum layered double hydroxides (LDHs) with intercalated chloride
Authors: Jayanthi K. , Neilsen Grace , Rosen Peter F. , Andersen Clark I. , Dickson Matthew S. , Evans Samuel F. , Paranthaman M. Parans , Woodfield Brian F. , Navrotsky Alexandra
Published: April 2021

Lithium aluminum chloride layered double hydroxide ([Li-Al-Cl] LDH) sorbents selectively recover lithium from geothermal brines, paving the way for increased domestic production of lithium for rechargeable batteries. In this work, cryogenic heat capacity measurements (CP) were performed from 1.8 to 300 K on several undoped and Fe-doped [Li-Al-Cl] LDH samples with a generalized compositions Li1–xAl2(OH)6Cl1–x (undoped) and LixFeyAl2–y(OH)6Clx (Fe-doped). Thermodynamic functions were generated from these measurements, and values of S298.15○ are reported based on both the CP measurements and configurational entropy (Sconfig○) arising from positional disorder in the layered structure. These results are combined with previous enthalpy of formation (ΔHf○) measurements to calculate the Gibbs energy of formation (ΔGf○) for the samples. In these samples, a higher water content results in a less negative ΔGf○ when doped and undoped samples are considered separately. Limited iron substitution for aluminum results in the most negative ΔGf○, but a larger dopant amount destabilizes the LDH structure. One of the samples had an anomaly in the heat capacity from 210 to 300 K, which is likely related to the movement of water in the structure due to the large H2O/Cl− ratio and the presence of vacancies in the interlayer where H2O resides. This indicates that the interactions between these species in the interlayer play an important role in stabilizing the LDH structure, and this effect should be further studied using different water/anion ratios.
Sustainability and strategy: A Brazilian integrative review
Authors: Nascimento Leandro da Silva , Steinbruch Fernanda Kalil , Ostermann Cristina M. , Costa Júnior Júlio César da , Salazar Viviane Santos
Published: April 2021

This paper aimed to understand how the fields of strategy and sustainability have been related in papers published in top Brazilian management journals. An integrative review was conducted in July 2019, consisting of a qualitative approach analysis. It was found that there are nine issues that permeate the relation between sustainability and strategy, such as critical analysis, which is present in Brazilian papers but has not been identified in international reviews on this topic. This study highlights the need for critical analysis in the sustainability-strategy relationship, a little-explored perspective in both literature and practice. As well, the adoption of organizational theories that can be used to analyze the sustainability-strategy relationship. Seeking to contribute to the scientific advancement of this topic, propositions for future research are presented.
Selection of Performance Objectives and Key Performance Indicators in PPP Projects: A Review
Authors: Mathew Anna , Nayar Seema K , Sathyapal Santhosh
Published: April 2021

Public-Private Partnerships (PPP), now applied widely in the global construction market, are more complex than conventional public procurements in economic, social, political, legal, and administrative aspects. Therefore, in order to ensure good performance and subsequent success of project, PPPs require a well-formulated performance management system that takes into consideration the perspectives of all stakeholders involved. A general agreement on how to measure success is necessary, which may be achieved by the definition of Performance Objectives (POs) of the project. Further statistical evidence, often labelled Key Performance Indicators (KPIs), may be employed to ensure that the actual progress is at par with the targeted. Determination of appropriate POs and KPIs is important for successful performance management. Numerous studies have been conducted worldwide to identify a desirable set of POs and KPIs in PPPs.
Influence of Shear Strength of Soil on Stresses in Footing-A Review
Authors: Sam Aleena , Anil A Arunima , Kurian Smitha Anna , Kabeer Sujina , J Jayamohan , Nath Aarya J
Published: April 2021

Shear strength characteristics of soil beneath the footing play a salient role on the stresses developed in the footing. In the design of foundation, it is imperative to analyse the stresses developed in it to prevent failures. Estimation of the influence of shear strength of underlying soil and flexural rigidity of footing on the shear force and bending moment developed in the foundation is necessary for effective determination of stress. Unlike conventional experimental methods, numerical analysis using Finite Element Method based geotechnical software like PLAXIS, FLAC, MIDAS etc. enables the analysis of foundations with complex stress characteristics. Finite Element Method (FEM) is a numerical analysis procedure that provides approximate solutions to various problems associated in the field of geotechnical engineering. This paper critically reviews the current literature on numerical methods to investigate the influence of shear strength of supporting soil on the structural forces developed in a footing. The relevance of the present approach to the concept of shear strength analysis is scrutinised by various numerical simulation analysis software.
A Review on the Seismic Performance Assessment of Steel Diagrid Structures
Authors: N Nourin , R Hazeena , Basheer Asif
Published: April 2021

In recent years, there is rapid increase in the construction of high rise structures due to the increase in population, high cost of land and restriction in horizontal growth due to less space. The advancements in the development of technological solutions and construction methods of high rise structures led to the innovative structural systems. One of the important criteria that need to be considered in the design of high rise structures is minimization of lateral loads. Hence, the importance of lateral load resisting system increased than structural systems that resist gravitational loads. Lateral loading due to wind and earthquake are the major factors that have to be considered in the design of high-rise structures. Diagrid structural system is recognized as a unique system in construction of high rise structures which is a variation of tubular structures. It consists of inclined members instead of vertical columns in conventional structures to carry both gravity and lateral loads. It gains popularity due to its structural efficiency and aesthetic potential gained by its unique geometric configuration. The present work reviews studies regarding seismic performance assessment of steel diagrid structures, studies on seismic performance factors of steel diagrid structures, impact of shear-lag effect and comparative studies on diagrids. Diagrids are found to be an efficient structural system for high rise structures in terms of structural efficiency as well as aesthetics. Also, it provides more economy, in terms of consumption of steel, thus making it cost-effective and eco-friendly.
LES ANOMALIES FÅ’TALES DIAGNOSTIQUEES A LHMSRO DURANT LANNEE 2020 : ASPECTS EPIDEMIOLOGIQUES
Authors:   HMSRO- Universite Mohammed V- Rabat., Ouzaa A. , Ouakasse S. ,   HMSRO- Universite Mohammed V- Rabat., Erhaymini K. ,   HMSRO- Universite Mohammed V- Rabat., Tazi Z. ,   HMSRO- Universite Mohammed V- Rabat., Filali A. ,   HMSRO- Universite Mohammed V- Rabat., Chraibi C. ,   HMSRO- Universite Mohammed V- Rabat., Alami M.H. ,   HMSRO- Universite Mohammed V- Rabat., Bezad R. ,   HMSRO- Universite Mohammed V- Rabat.
Published: April 2021

Les anomalies congenitales sont des anomalies de structure ou de fonction, dont les troubles metaboliques, presentes a la naissance. Bien quelles puissent etre dorigine genetique, infectieuse ou environnementale, il est le plus souvent difficile den determiner la cause exacte. Nous rapportons lexperience de lHÃ´pital Maternite Sante de Reproduction les Orangers HMSRO a propos de 47 cas danomalies fÅ“tales colligees sur une annee du 1er Janvier au 31 Decembre 2020 , sur un nombre total de 7317 naissances, soit une prevalence de 0,64 %. Les anomalies fÅ“tales retrouvees sont : les anomalies multiples, squelettiques, genitales, neurologiques, genetiques, cardiaques, digestives, ORL et les anomalies vasculaires. Les facteurs de risque lies a la survenue des anomalies congenitales sont la prise de medicaments et/ou de plantes (fenugrec), et la notion de contact avec les produits chimiques durant la grossesse, ainsi que la presence de pathologie chronique chez la mere essentiellement le diabete. 15 anomalies fÅ“tales ont ete diagnostiquees en antenatal alors que 32 ont ete diagnostiquees a la naissance. Letude des anomalies congenitales doit etre faite dans chaque pays afin de determiner leur prevalence, leur nature, les causes et les facteurs de risques associes et permettre des mesures de prevention specifiques.
ASSESSMENT OF THE LEVELS OFCARDIOPULMONARY RESUSCITATION (CPR) AMONG MEDICAL STUDENTS IN NORTHERN SAUDI ARABIA
Authors:   Department of Pathology, College of Medicine, University of Hail, KSA., Gadelkarim Ahmed Hussain , Alkhuraisi Fatimah ,   College of Medicine, University of Hail, KSA., Alsulami Ethar ,   College of Medicine, University of Hail, KSA., Algriys Muradi ,   College of Medicine, University of Hail, KSA., Alshammari Kholah ,   College of Medicine, University of Hail, KSA., Alshammri Abdulaziz ,   College of Medicine, University of Hail, KSA.
Published: April 2021

Background: Cardiopulmonary resuscitation is a lifesaving maneuver if provided at the right time and it can improve the mortality rate in medical emergencies. The accurate knowledge regarding CPR is an essential and integral part to deliver an adequate and successful resuscitation in such cases. This study aims to assess the knowledge among undergraduate medical students in CPR at the Northern Region Universities of Saudi Arabia. Methods: This is a cross-sectional study assessing CPRknowledge among medical students. The data was carried out on 731 medical students (231 fourth year, 285 fifth year and 215 sixth year medical students) from different colleges in the northern Saudi area by an online self-administered questionnaire that aimed to evaluate their knowledge regarding basic life support (BLS) and CPR techniques in neonates, children, and adults. Results: The data showed the mean knowledge scores of CPR among medical students according to university are represents as follows University of Tabuk (50.5%), University of Hail (47%), Al Jouf University (45%), and Northern border university (43%). The mean knowledge scores of CPR among medical students according to academic year are represents as follows fourth year (45.5%), fifth-year (47.6%), and sixth year (45.3%). Conclusions: The level of BLS awareness among medical students is generally poor. The introduction of regular BLS courses into the undergraduate curriculum is a must to increase the level of knowledge among these future physicians. A shorter training period as well as recurrent and regular refreshing courses are also recommended.
SCOPE OF AYURVEDA IN MODERN ERA: NEW HORIZONS
Authors: Lathakalidas Amrutha
Published: April 2021

Health is elemental for good quality of life and a good healthcare system is a cornerstone of sustainable society. World health statistics 2019 summarises that, the global health status have been improved over the decades. Even though there are phenomenal achievements in global life expectancy and infectious disease management , the new outbreaks of communicable diseases and the additional burden of Non-communicable diseases stands as a flaw in the modern medical system that emerged in 18th century. It is at this point, there exists the need of bringing alternative system of medicine to the main stream for better disease prevention and management. In such a scenario- Ayurveda (the science of life) Â– the science coming under the umbrella of alternative system of medicine as well as the one focussing on mind ,health and spirituality becomes imperative. The current inclination for healthy diets, immunity enhancement ,rejuvenation and lifestyle management, calls for retroactive and proactive attempts to bring Ayurveda in the mainstream of health care. . In a modern era where the whole world is inclining for Ayurveda, India -the land rich for its traditions and heritage should step forward with its own indigenous system of medicine.
OBSTRUCTIVE SLEEP APNEA
Authors:   Post Graduate Student, Dept. of Pediatric and preventive Dentistry, Divya Jyoti College of Dental Science and Research., V.G Hridya , Somani Rani ,   Professor and Head, Dept. of Pediatric and preventive Dentistry, Divya Jyoti College of Dental Science and Research., Jaidka Shipra ,   Professor, Dept. of Pediatric and preventive Dentistry, Divya Jyoti College of Dental Science and Research., Jawa Deepti ,   Professor, Dept. of Pediatric and preventive Dentistry, Divya Jyoti College of Dental Science and Research., Madhu Aiswarya ,   Post Graduate Student, Dept. of Pediatric and preventive Dentistry, Divya Jyoti College of Dental Science and Research., Sabin Muhamed ,   Professor, Dept. of Pediatric and preventive Dentistry, Divya Jyoti College of Dental Science and Research.
Published: April 2021

Obstructive sleep apnea is an under recognized and under diagnosed medical condition, with a myriad of negative consequences on patients health and society as a whole. The most acting reason behind Obstructive sleep apnea given as in literature is due to recurrent episodes of upper airway (UA) collapse during sleep. Episodes may last 10 seconds or longer and commonly last 30 seconds or longer. From the mid-1990s to the present, we have seen an explosion of basic, clinical, and population research directed toward the prevalence, causes, consequences, and treatment of this long-standing, although only recently appreciated, problem. Sleep apnea has attracted a myriad of researchers from diverse disciplines and clinical subspecialties. At the same time, sleep apnea as a serious, undefined clinical problem has also given birth to many sleep medicine clinics throughout the western world. Finally, given the relatively high prevalence of this sleep-specific problem with potential carryover to daytime pathology, sleep apnea has provided great impetus to the growth of sleep medicine as a clinical and research specialty. Dentists have been involved in the collaborative evaluation and treatment of patients with OSA using oral appliances from 1980. Importantly, dentists play a crucial role in evaluating patients with OSA for the suitability of appliance therapy, choosing and adjusting the appliance and assessing the patient for adverse effects. To accomplish holistic treatment approach it is essential that dentists and the sleep medicine physician should work collaboratively. When this occurs, patients will have the best opportunity for the effective treatment of their OSA.
PREVALENCE OF ERECTILE DYSFUNCTION IN UROLOGY CONSULTATION: A PROSPECTIVE STUDY
Authors: Oubihi Mohamed , Soussi Souleimane , Karmouch Yacine , Benazzouz Abderrezak , Hajji Fouad , Ghoundale Omar
Published: April 2021

Introduction:Erectile dysfunction is defined by the inability to obtain or maintain an erection sufficient to allow a satisfactory sexual relationship, according to the 2nd International Conference on Sexual Dysfunctions of 2004. This constitutes an attack on virility, and is a source of significant psychological suffering for the individual as well as for his partner. Erectile dysfunction is also a multifactorial disease, related to the overall physical and psychological health of the patient. Materials And Methods: The survey was conducted during three months in the military hospital of Avicenne in Marrakesh. It involved all patients consulting in Urology aged over 18 years regardless of the reason of consultation. Data was collected through a questionnaire by direct interview. The evaluation of ED was based on the definition of the 2nd International Conference of Sexual Dysfunction of 2004. Results: The analysis included 482 patients. The average age of patients was 51 Â± 11 years. The main reason for consultation was a prostate problem (45.2%). ED was indicated as reason for consultation by 5.1% of patients. The overall prevalence of ED was 46%. 35.2% already discussed it with a doctor. ED was significantly correlated with age, benign prostatic hyperplasia, cardiovascular risk factors, prostate and pelvic surgery (P<0.001). 29.7% of ED patients used PDE5 inhibitors, 54% found it to be effective. Conclusion: This survey confirms the high prevalence of ED and its important underreporting. Physicians are encouraged to ask patients about ED, especially since there are now simple and effective therapies.
AL-FUZAI:A SAUDI ARABIAN WRITER
Authors:   Gizan, Saudi Arabia., H. Dohal Gassim
Published: April 2021

Khalil I. Al-Fuzai is a Saudi Arabian literary scholar. He shared his culture with others and was effective in addressing many of the social, political, and religious problems that he saw in his society. Al-Fuzai will be presented to the readers of this journal in this short article.
BONE SUBSTITUTES IN 3D PRINTING OF BONE SCAFFOLDS FOR GUIDED BONE REGENERATION
Authors:   Internal Dentist CCTD-CHU Ibn Rochd Casablanca Morocco., A. Boualam , K. El. Boussiri ,   Professor of Higher Education in Biomaterials Faculty of Dentistry Casablanca Morocco., K. El. Guermai ,   Professor of Higher Education in Biomaterials Faculty of Dentistry Casablanca Morocco., N. Elmoutawakkil ,   4rd year resident in the Department of Removable Dentures CCTD -CHU ibn rochd Casablanca Morocco.
Published: April 2021

Purpose: The purpose of this study is to:Highlight the difficulty of using a bone (autologous, allograft) in tissue engineering.Present the different bone substitutes (of natural or synthetic origin used in guided bone regeneration alone or in combination.Describe the different materials and 3D printing techniques of bone scaffolds for bone regeneration. Material And Methods: Research to the Scaffolds and its use in dentistry between January 2012 and December 2020 in Medline via PubMed, Google Translate, Google Library. Results:38 articles were found in the database with the following keywords: bone, 3D regeneration, scaffolds, 3D impression. Conclusion:It is generally accepted that the problems and challenges in the development and application of 3D printing can be solved by printing 3D scaffolds.
Assessment of drought resistance of alfalfa breeding material according to water regime indicators in the South of Ukraine
Authors: Vozhehova R. A. , Tyshchenko A. V. , Tyshchenko O. D. , Dymov O. M. , Piliarska O. O. , Smulska I. V.
Published: April 2021

Purpose is to evaluate the plant breeding material of alfalfa by the indices of water metabolism in different conditions of humidification, to determine the patterns of their manifestation, correlation ties between them and drought tolerance, to point out the best material for introduction into the plant breeding process.
Methods. Field, laboratory, statistical.
Results. During 2017–2020, 9 populations of alfalfa were studied by the indices of water regime: water content in the tissues, water deficit and water holding capacity of the leaves in the conditions of irrigation and natural humidification. The regularities of their manifestation were determined. By the data on the water content in leaves it was found out that it is high at irrigation (81.88; 79.63; 78.42%) and low (69.20; 70.81; 71.84%) without irrigation. Water content in leaves is closely related with water deficit, but the connection is inverse (r = -0.986 at irrigation and r = -0.863 at natural humidification). Water deficit in the populations was the highest (50.28–29.96–33.0%) in the stress conditions (without irrigation) and decreased in the plants at irrigation to 12.64–17.37–22.04%. Water deficit relates to water holding capacity of leaves: the greater water deficit, the lower water holding capacity. In the irrigated conditions, 13.9 to 17.3% was lost in 2 hours of the leaves wilting and 30.3–34.6% after 8 hours, and 3.78–4.31% in 1 hour. Water holding capacity ranged from 82.7 to 85.9% after 2 hours of the leaves wilting, and 61.6 to 69.7% after 8 hours. In the conditions of natural humidification, in the first 2 hours after wilting, the water content decreased by 8.5–11.7%, after 8 hours – by 16.5–22.6%. Water loss per one hour ranged from 1.78 to 2.84%, 1.5–2.0 times less than in irrigated plants. Water holding capacity was 82.3–91.5 and 77.0–91.5% after 2 and 8 hours, respectively. It was high (90.3–91.5 and 83.4–91.5%) in the following populations: LRH, M.q./M.agr., A.r.d. and M.agr.C. at water loss of 1.78–2.15%. A high inverse connection was found between water loss and water holding capacity after 2 and 8 hours: r = -0.652 and r = -0.963, respectively. There was a significant positive relationship between water holding capacity and drought tolerance (r = 0.597–0.696). High drought tolerance (56.9–58.2%) was recorded in the populations: M.agr.C., M.q./M.agr., LRH and Ram. D.
Conclusions. Regularities of changes in tissue water content, deficit and water holding capacity of alfalfa leaves during irrigation and in conditions of natural humidification were revealed. The relationships between water deficit and water holding capacity, water loss and water holding capacity, water hol­ding capacity and drought tolerance were determined. The best populations with high drought tolerance were selected to be introduced into the plant breeding process.
De grupo de presión a actor político: infraestructuras de paz y madurez del conflicto en Colombia
Authors: Molina Correa Javier Alexander , Vargas Velázquez Sergio
Published: April 2021

Las infraestructuras de paz, desde su génesis en la administración de Belisario Betancur, en Colombia, han sido grupos de presión de carácter privado y mixto en menor medida, que están en una constante lucha por constituirse como un actor político con un grado mayor de institucionalización, valiéndose de la movilización social de manera pacífica. Estos grupos de presión a diferencia de los partidos, solo pretenden influir el sistema político. Se concluye que las infraestructuras de paz, hantransitado de ser un grupo de presión a un actor político con participación directa ynecesidades puntuales en el posconflicto
La política colombiana de emprendimiento en educación y su impacto en el acceso al empleo de jóvenes
Authors: Avendaño Castro William Rodrigo , Luna Pereira Henry Orlando , Quintero Camacho Laudith
Published: April 2021

La política colombiana de emprendimiento en educación sobre el acceso al empleo de los jóvenes egresados de educación media, traducida en la denominada formación técnica en el ámbito de la educación, cumple su propósito de adiestrar a los estudiantes en determinadas competencias laborales específicas, pero no su objetivo de mejorar la calidad de vida y ampliar las potencialidades de los estudiantes frente a su proyecto de vida y no ha tenido un impacto favorable sobre las posibilidades de acceso al empleo de los jóvenes.
Geoeconomia Híbrida da China na América do Sul
Authors: Rodrigues Bernardo
Published: April 2021

A participação ativa da China na América do Sul se inicia com a sua entrada na OMC, em 2001, modificando o tabuleiro geopolítico tanto na região quanto nas relações internacionais em geral. Esse reequilíbrio das relações de poder, suplantando a outrora breve unipolaridade, permitiu sua atuação mais enfática. Dessa forma, essa expansão chinesa é crescentemente constatada principalmente em termos econômico-financeiros. Entretanto, é visualizado que tal participação mais ativa vem apresentando uma dualidade que gera, concomitantemente, benefícios e malefícios para aseconomias sul-americanas. O presente artigo busca debater essa característica específica, apresentando a hipótese de instauração de uma Geoeconomia Híbrida, definida como a utilização de instrumentos econômicos através de um dualismo multifário e assimétrico. Desse modo, a partir de uma metodologia empírico-dedutiva baseada em dados quantitativos e qualitativos, objetiva-se evidenciar que, ainda que os instrumentos geoeconômicos chineses sejam um direcionamento estratégico não impositivo, podem acarretar em externalidades negativas para as estruturas produtivas sul-americanas e fluxos intrarregionais no longo prazo.