bluuebunny/crossref_metadata_2025 huggingface dataset:
Penelitian Tentang Kesediaan Konsumen Untuk Membayar Produk Partisi Modular Ramah Lingkungan
Authors:   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Adryan A. Adryan A. , Dimastyo L Dimastyo L ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Ferly S Ferly S ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Valentina  A.G Valentina  A.G ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia, Vania T.B Vania T.B ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia
Published: March 2021

Indonesia merupakan negara berkembang dimana pertumbuhan di berbagai sektor sedang gencar dilakukan, salah satunya adalah sektor konstruksi. Pembangunan berkelanjutan kemudian menjadi perhatian utama penelitian dimana salah satu faktor yang berkontribusi pada pembangunan berkelanjutan adalah material bangunan. Tujuan dari penelitian ini adalah untuk mengelompokkan dan menguji indikator- indikator sesuai dengan variabel yang berhubungan dengan pembelian produk Floor Mounted Modular Wall System Mycotech sebagai partisi modular ramah lingkungan oleh konsumen. Penyebaran kuesioner digunakan untuk pengambilan data dengan teknik purposive sampling terhadap 100 responden. Data yang terkumpul kemudian dianalisis dengan exploratory factor analysis dan linear regression. Hasil dari penelitian ini menunjukkan bahwa faktor kontekstual dan faktor perseptual seperti persepsi individu, kepercayaan, komitmen perilaku, kualitas standar, nilai ekonomis, dan karakteristik produk mempengaruhi kesediaan responden untuk membayar produk ramah lingkungan.
Impact of temperature on chlorination strategies for mussel control at water treatment plants
Authors: Alonzo-Moya Carlos , Lake-Thompson Ian , Hurtado Alonso , Hofmann Ron
Published: March 2021

Drinking water treatment plants in the Great Lakes often protect their intake structures against dreissenid biofouling by prechlorinating when water temperatures exceed 12 °C. This temperature threshold is based on the reproduction characteristics of zebra mussels. However, in recent years, zebra mussels have largely given way to quagga mussels in the region. These mussels reportedly reproduce at temperatures as low as 5 °C. The objective of this study was to determine if the current 12 °C trigger point for prechlorination remains appropriate. A 3-year monitoring program using bioboxes recorded mussel veliger concentrations and settlement potential in water drawn from the intakes of three drinking water treatment plants on Lake Ontario. Water temperature was a poor predictor of veliger presence and settlement. Reproduction and settlement were observed outside of the traditional temperature thresholds. Furthermore, no relationship was found between the number of veligers in the water column and those settling, suggesting that there are complex environmental factors that influence mussel activity. Nevertheless, it was observed that settlement occurred consistently between the months of July and November in the 3 years of the study. Therefore, a calendar-based approach to trigger prechlorination, as opposed to a temperature-based approach, is suggested.
THE BOUNDARIES PROBLEM OF THE 1950 EUROPEAN CONVENTION DYNAMIC INTERPRETATION ON HUMAN RIGHTS ON THE EXAMPLE OF ENSURING THE SOCIAL RIGHTS OF CONVICTS
Authors: KLYUCHNIKOV Andrew Yu.
Published: March 2021

The 1950 Convention for the Protection of Human Rights and Fundamental Freedoms is an instrument for the dynamic development of the human rights system in the member states of the European Council. Such an active formation of the latter is due to the activities of the European Court of Human Rights. However, the case-law of the court is not always accepted in national jurisdictions, especially when it comes to the most sensitive areas of life in modern societies. As the goal of the research, the author sets out the identification of the current approach of this international court to the problem of social rights of convicts, especially in the context of ensuring their social rights. The material for the research was the case-law of the ECHR on the social rights of citizens - with special attention to the rights of persons in places of isolation from society, the legal positions of domestic researchers on the problem posed. The author uses traditional research methods - general scientific and special, with an emphasis on historical, social and legal methods. The paper describes the stages of the international soft law sources formation on penitentiary rules and the impact on this of the ECHR practice in the context of the discrimination standarts prohibition regarding the right of ownership and violation of the forced (compulsory) labor prohibition. A common European standard “the right of a convicted person to retire” has not yet been developed, which has been confirmed in the practice of the ECHR. This decision is due to the need to maintain the effectiveness of the entire convention system, the policy of compromises with states. Through the dynamic interpretation of the ECHR, this right is recognized as an element of the convention rights protection, the convict should be granted an increasing amount of social rights.
DISTANCE EMPLOYMENT AS AN INSTITUTION OF WORKING TIME AND THE MAIN EVOLUTIONARY TYPE OF EMPLOYMENT IN A PANDEMIC
Authors: Yasinskaya-Kazaschenko Angelika V. , Sholomitskaya Irina V.
Published: March 2021

The development of the digital economy, the change in the image of workers, their values, as well as the threat of a global pandemic indicate the further development and widespread introduction of non-traditional forms of employment. The article examines the historical preconditions for the formation of a distance form of employment. The authors conclude that distance employment is an evolutionary form of employment and, in the context of the COVID-19 pandemic, is designed to ensure the stability of labor relations. The features of the legal regulation of distance work in the Republic of Belarus are analyzed, a comparative analysis of the legal regulation of distance employment in the Russian Federation is carried out. The main mistakes made by employers when transferring workers to remote work have been studied. Basic recommendations are given for transferring employees to a remote form of employment, taking into account the requirements of the legislation of the Republic of Belarus. There were used such methods as analysis, synthesis, dialectical, historical, formal logical, formal legal and comparative legal in this research.
DIDACTICS OF LOGIC IN KEN SCHOOLS AND THE CONCEPTION OF LOGICIN THE "ENCYCLOPÉDIE OU DICTIONNAIRE UNIVERSEL RAISONNÉ"
Authors: Janeczek Stanisław
Published: March 2021

The paper describes the conception of logic in Polish didactics authored by the Commission of National Education (KEN), an important educational institution of the European  Enlightenment. Since the documents of the Commission refer to a vision of science presented by such influential works then as the Encyclopédie ou dictionnaire universel raisonné [Great French Encyclopedia], the paper compares the requirements from the Commission’s programmer with the encyclopaedic entries that entail logical problems broadly understood. It turns out that the Commission, following the Encyclopédie, not only recommended a list of textbooks of logic but also shared its eclectic vision of logic. Although it is characteristic of modernity to take a relative approach to the importance of traditional logic, transformed into science on method, or literally an outline of epistemology, understood according to É. Condillac as a specific form of metaphysics, nevertheless some elements of logic were eclectically made valid. This logic, from the times of I. Kant, has been defined as formal logic. Practical logical skills were preferred to the knowledge of logical theories. At the same time attention was paid to the meaning of natural logical skills, and drills in logical reasoningwhen studying languages and mathematics. Despite preferences for the analytical method they also noticed the importance of synthetic method. It seems also that although the documents of the Commission do not say anything about the teaching of syllogistic issues, in didactic practice inspired by the Encyclopédie in the schools controlled by the Commission, the room was made to teach these problems. Condillac’s book was preferred in the schools controlled by the Commission, nevertheless, it was not, as in the case of other textbooks, a must on the reading list, an obligatory reading matter, therefore it was not published in Poland. The conception of logic presented by the Commission as modelled on the Encyclopédie managed to avoid the one-sidedness of Condillac’s approach, the approach that in fact eliminated the teaching of logic.
THE PROBLEM OF LOGICAL FORM: WITTGENSTEIN AND LEIBNIZ
Authors: Piekarski Michał
Published: March 2021

The article is an attempt at explaining the category of logical form used by Ludwig Wittgenstein in his Tractatus logico-philosophicus by using concepts from Gottfried Wilhelm Leibniz’s The Monadology. There are many similarities and analogies between those works, and the key concept for them is the category of the inner and acknowledged importance of consideration based on basic categories of thinking about the world. The Leibnizian prospect allows for a broader look at Wittgenstein’s analysis of the relation between propositions and facts, between language and the world. Using the Hanoverian philosopher’s terminology allows for the demonstration of the ambivalence of the concept of logical form in the philosophy of Wittgenstein and also the metaphysical nature of his first book.
PHILOSOPHY AS A SYSTEM OF CONDITIONALS
Authors: Nieznański Edward
Published: March 2021

Philosophical statements are often suppositions. Gottfried Wilhelm Leibniz proposes in Nouveaux Essais sur l’entendement humain, 1704, a method of the construction of assertive conditionals occurring between any philosophical suppositions. If we can infer a philosophical statement from any suppositions then the implication between these suppositions and the obtained statement is assertive. In the article, some examples of the application of Leibniz’s method are considered.
SOME REMARKS CONCERNING VIRTUALITY
Authors: Latawiec Anna
Published: March 2021

The development of computer sciences has transformed the way of thinking and our perception of the world. To express this new view of the world, a new language is created, which uses such notions as “virtuality”, “virtual world”, “virtual reality”. These words have already worked in our colloquial speech and our thinking. However, they are used in various contexts and have a different meaning. The paper offers some remarks on the problem of the meaning of these notions and draws some consequences of their interpretation.
Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review
Authors: Matossian Margarite D. , Wells Carrow I. , Zuercher William J. , Collins-Burow Bridgette M. , Drewry David H. , Burow Matthew E.
Published: March 2021

Mitotic kinases have integral roles in cell processes responsible for cancer development
and progression in all tumor types and are common targets for therapeutics.
However, a large subset of the human kinome remains unexplored with respect to functionality
in cancer systems. Within the mitotic kinases, the never-in-mitosis kinase (NEK)
family is emerging as novel kinase targets in various cancer types. NEK5 is an understudied
member of the NEK family. While there are more recent studies describing the
physiologic function of NEK5, its role in cancer biology remains widely understudied.
However, emerging studies implicate that NEK5 has potentially crucial functions in various
solid tumors. In this review, we discuss current knowledge regarding the role of
NEK5 in cancer and the implications of NEK5 expression and activity in tumor development
and metastasis. We summarize current studies that examine NEK5 activity in diverse
cancer systems and cellular processes. As an understudied kinase, there are currently
no selective NEK5-targeting agents to test the effects of pharmacologic inhibition on
cancer, although there exist recent advancements in this area. Here we also include an update
on efforts to develop selective pharmacologic inhibition of NEK5, and we discuss
the current direction of NEK5-targeting therapeutic development. The generation of selective
NEK5 inhibitors is promising new targeted therapies for cancer growth and metastasis.
The Application of Cell-Penetrating-Peptides in Antibacterial Agents
Authors: Chen Hangfei , Battalapalli Dheerendranath , Draz Mohamed S. , Zhang Pengfei , Ruan Zhi
Published: March 2021

Multidrug resistance in bacteria is a major threat to global health and the effective
prevention and treatment of infections. The urgent need for novel antimicrobial
agents, together with the increasing challenges in discovering and developing effective
antibiotics, has inspired new approaches and strategies to circumvent antibiotic resistance.
Despite this effort, the difficulty in cell-penetration and delivery of antibiotics into
bacterial cells remains the bottleneck for both traditional and non-traditional antibacterial
agents to realize their full potential. Recently, cell-penetrating peptides (CPPs) have attracted
considerable attention as low-toxicity carriers, promising the improvement of the
low biological activity of traditional antimicrobial agents. CPPs are now extensively used
to deliver various antibiotics, including recently developed agents, such as antisense oligonucleotides
(ASOs). The conjugation of CPPs to antimicrobial peptides (AMPs) can also
greatly enhance antibacterial activity and may present an effective approach for developing
novel antimicrobial agents. This review discusses the characteristics, designing
strategies, and recent progress in the development and application of antimicrobial CPPs
as potent antibacterial agents against multidrug-resistant bacteria.
GCSF as a Potential Molecular Target for Overall Survival of
Hepatocellular Carcinoma
Authors: Cao Heng , Guo Peng , Wu Xiaohui , Li Jiankun , Ge Chenlong , Wang Shunxiang
Published: March 2021

Background:

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of digestive tract in the world. Therefore, it is important to carry out studies on the molecular mechanisms of early diagnosis and treatment of HCC to reduce mortality.

Methods:

Bioinformatic analysis was performed to explore the significant role of GCSF on the occurrence and development of neoplasm. Differently expressed genes (DEGs) were screened, and the significant hub genes related with GCSF were identified by the multiple algorithms of Cytoscape. Functional annotation for DEGs, pathological stage and overall survival analysis were implemented. In addition, the verification for the role of GCSF on HCC was made via the clinical samples. A total of 70 participates diagnosed as HCC were recruited from November 2014 to November 2019. The immunohistochemistry assay, qRT-PCR, receiver operating characteristic (ROC) curves, and overall survival analysis were carried out.

Results:

GCSF was related with the tumor size, and the expression of GCSF was up-regulated in hepatocellular carcinoma tissues. The enrichment results of GO and KEGG analysis were mainly enriched in “Inflammatory response”, “Protein binding”, “Metabolic pathways”, and “Proteasome”. The tumor diameter (P < 0.001), and survival time (P < 0.001) were significantly associated with expression of GCSF via the verification of clinical data. The univariate and multivariate Cox proportional regression analysis manifested that high expression of GCSF in patients with HCC was related to poor OS.

Conclusion:

The expression level of GCSF is significantly associated with the prognostic survival of HCC, and it is expected to become a new prognostic marker of HCC, providing a novel idea for future basic research as well as targeted therapy.
Protein Phosphatase Type 2C Functions in Phytohormone-Dependent Pathways and in Plant Responses to Abiotic Stresses
Authors: Chuong Nguyen Nguyen , Hoang Xuan Lan Thi , Nghia Duong Hoang Trong , Dai Thai Ngoc Trang , Thi Van-Anh Le , Thao Nguyen Phuong
Published: March 2021

Plants, as sessile organisms, are susceptible to a myriad of stress factors, especially abiotic
stresses. Over the course of evolution, they have developed multiple mechanisms to sense and
transduce environmental stimuli for appropriate responses. Among those, phosphorylation and
dephosphorylation, regulated by protein kinases and protein phosphatases, respectively, are
considered crucial signal transduction mechanisms. Regarding the latter group, protein phosphatases
type 2C (PP2Cs) represent the largest division of PPs. In addition, the discovery of regulatory
functions of PP2Cs in the abscisic acid (ABA)-signaling pathway, the major signal transduction
pathway in abiotic stress responses, indicates the significant importance of PP2C members in plant
adaptation to adverse environmental factors. In this review, current understanding of the roles of
PP2Cs in different phytohormone-dependent pathways related to abiotic stress is summarized,
highlighting the crosstalk between the ABA-signaling pathway with other hormonal pathways via
certain ABA-related PP2Cs. We also updated the progress of in planta characterization studies of
PP2Cs under abiotic stress conditions, providing knowledge of PP2C manipulation in developing
abiotic stress-tolerant crops.
Targeting Stress Response Pathways with Alternative Strategies as a Novel Antifungal Approach
Authors: Ruhil Sonam , Kumar Vikash , Balhara Meenakshi , Malik Monika , Chhillar Anil K.
Published: March 2021

Fungi are recognized as key pathogens in immunocompromised patients. The invasive infection
always remains a problem for clinicians due to high morbidity and mortality. The treatments of fungal
infections are hampered by conventional drugs, which are associated with resistance. Drug resistance
has become an important problem in a variety of infectious diseases. The rise in the incidence of fungal
infections and drug resistance has intensified the need for alternative therapies that affect a new target.
This new target must be a growth essential gene product like the stress pathway. It has been found that
stress pathways can be a potential target in opportunistic fungal infection, which played an important
role in the virulence of pathogens. It was helpful in protection from host defense, normal fungal growth, and
antifungal drug resistance. The disruption of the pathway using alternative strategies (chemosensitization and
photo-dynamics therapy) can be a novel approach in fighting fungal infections and for drug design.
Relationship between Augmentation Index and Wall Thickening Fraction during Hypotension in an Animal Model of Myocardial Ischemia-Reperfusion and Heart Failure
Authors: Wray Sandra , Lascano Elena , Negroni Jorge , Fischer Edmundo C.
Published: March 2021

Aims:

Non-invasive indices to evaluate left ventricular changes during ischemic heart
failure are needed to quantify the myocardial impairment and the effectiveness of therapeutic manoeuvres.
The aims of this work were to calculate the Wall Thickening Fraction (WTF) and the
Augmentation Index (AIx) and to assess the relationship between WTF and AIx using data obtained
from an animal model with heart failure followed by a myocardial ischemia stage and a
reperfusion stage.

Methods:

Nine Corriedale sheep that had been monitored for 10 minutes during a basal stage underwent
5-minute myocardial ischemia, followed by 60-minute reperfusion. Seven of them were subjected
to an induced heart failure through an overdose of halothane, two of which were treated with
intra-aortic counterpulsation during the reperfusion stage. The remaining two animals were monitored
during their ischemia-reperfusion stage.

Results:

Data obtained in the 5 animals suffering from heart failure followed by myocardial ischemia
showed that: a) heart failure induction determined decrease in cardiac output, cardiac index
and systolic and diastolic aortic pressure (AoP) with respect to their basal values (p<0.05), b) myocardial
ischemia decreased the WTF compared with basal and induced heart failure values
(p<0.05), c) during the reperfusion stage accompanied by induced heart failure, WTF increased
with respect to values observed during the ischemia induction stage (p<0.05); nevertheless, basal
values were not recovered after reperfusion (p<0.05). During this 60-minute stage, systolic and diastolic
AoP values were lower (p<0.05) than those at the basal stage.

Conslusion:

AIx and WTF values calculated from synchronically recorded values of aortic pressure
and left ventricular wall thickness during the reperfusion stage in all animals (n = 9) showed a
negative correlation (p<0.05). Analysed data provided evidence of a negative relationship between
a left ventricular index of myocardial function and an arterial index obtained from AoP waves.
Challenges in Breast Cancer Control in Malaysia
Authors: Mokhtar Noor Fatmawati , Dewadas Hemaniswarri Dewi , Haron Juhara , Yahya Maya Mazwin , Norsa’adah Bachok , Zain Wan Zainira Wan , Sulong Sarina , Abdullah Jafri Malin , Zin Reena Rahayu Md
Published: March 2021

:

High proportion of late presentation and poor survival of women with breast cancer in
Malaysia does not reflect the country’s status as the third richest country in South East Asia.
Herein, we examined, and collated research articles related to breast cancer trajectory i.e., primary,
secondary, and tertiary prevention in Malaysia to understand, appreciate and recognize the achievements
but also gaps which undermine Malaysia’s response in handling the disease. In summary,
the integral task for Malaysia is to strategically align research to improve local data (research) on
the extent of the country’s breast cancer problem, so that effective, comprehensive, and evidence-
based cancer control programs founded on resource level can be generated.
Gold Particles Recovery using Novel Reducing Agent with Regard to Continuous Approach
Authors: Feizbakhsh Alireza , Fotovat Alireza , Garmaroudi Ali Bagheri
Published: March 2021

Background:

Over 300 tonnes of gold utilised in electronics devices every year, end-of-life electronic equipment offers an crucial recycling potential for secondary gold supply. Electronic boards are among common and exploitable sources of gold that are widely used in various industry. The aims of this paper is to use gold element of electronic boards by adjusting its surface functionality and particle size to make this metal to be used in various applications

Methods:

to gain this purpose by using acidic solutions and up to bottom chemical synthesis method among physical, chemical, and biological methods and by transferring gold particle size from micrometer to nanometer, surface-area-to-volume ratio will be increase such that new structural properties emerge, change, or improve.

Results:

Tests such as Fourier-Transform Infrared spectroscopy, X-Ray Diffraction, and Field Emission Scanning Electron Microscopy have confirmed high-quality production and proper extraction of gold particles on a nanometer scale from electronic plates and confirmed crystalline structure of extracted gold in range of 70-110 nm.

Conclusion:

The main objective of this research is to derive and fabricate gold nanoparticles using chemical oxidative route using HCl and Aqua regia to produce gold nanoparticles in Nano dimension scale. Results has shown that gold nanoparticles are synthesized successfully via chemical process. Moreover, Acid concentration and reaction time has enormous effect on production procedure.
Rapid Arc-SBRT: Non-Invasive Immune Adjuvant for Advanced Stage Non-Small Cell Lung Carcinoma
Authors: Chairmadurai Arun , Jain Sandeep K. , Jain Aklank , Prakash Hridayesh
Published: March 2021

In conjunction with radio-chemotherapy, pulmonary resection is recommended for early-stage nonsmall- cell lung carcinoma but not for advanced-stage NSCLC patients having high-grade metastatic lesions. In these cases, the rapid Arc-Stereotactic body radiotherapy (Ra-SBRT) technique offers a therapeutic advantage by delivering focal irradiation to metastatic lung lesions and reduces the bystander toxicity to normal tissues. We have previously demonstrated that Ra-SBRT ablates metastatic lesions and induces tumor immune rejection of metastatic tumors by promoting in situ programming of M2 TAM towards M1-TAM and infiltration of Siglec-8+ Eosinophils. Most interestingly, Ra SBRT has very low abscopal impact and spares normal tissues, which are the significant limitations with conventional radiotherapy. In view of this and the immune adjuvant potential of Ra SBRT, it promotes normalization of aberrant vasculature and inhibits the metastatic potential of NSCLC lesions. In view of this, we here propose that Ra-SBRT indeed represents an immunogenic approach for the effective management of advanced-stage NSCLC.
Bridging Indigenous Knowledge and Scientific Evidence for Pharmacological
Studies of Phaleria macrocarpa: A Systematic Review
Authors: Mia Md. Abdur Rashid , Ferdosh Sahena , Ahmed Qamar Uddin , Helaluddin Abul Bashar Mohammed , Sarker Md. Zaidul Islam
Published: March 2021

Background:

Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred
to as God’s crown, Mahkota dewa, Pau, grows all year long in tropical countries, including
Malaysia, Indonesia, Papua New Guinea, and Australia. It is traditionally used to treat haemorrhoids,
stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine,
acne, and skin ailments.

Objective:

The purpose of this systematic review is to provide important insight on P.
macrocarpa’s traditional use, toxicity, classification of compounds, and pharmacological activities,
thus identifying the gap in scientific analysis and potential analytical opportunities for future directions
on this herb.

Method:

The related data for this systematic review were collected from renowned online databases,
namely Wiley Online Library, Web of Science, Springer Link, PubMed, Science Direct, Scopus,
and Google scholar.

Results:

Around 48 compounds, including benzophenone, xanthonoids, norcucurbitacin derivatives,
flavonoids, lignans, fatty acids and esters, phytosterols, aromatic acids, etc., were identified
from different parts. These constituents and different solvent extracts using various identification
techniques have been reported to show a broad range of pharmacological activities. Besides various
traditional claims and pharmacological functions, scientific evidence on its ethnopharmacological
aspects has been well-documented. Studies found that the plant demonstrates anti-diabetic, anti-
oxidant, antimicrobial, anticancer, anti-hypercholesterolemia, and antihypertensive activities.

Conclusion:

Despite various claims, there is still inadequate scientific evidence, particularly on P.
macrocarpa’s benefit in the management of dysentery, asthma, skin diseases, and rheumatoid
arthritis, necessitating future studies. There is also a need to test its pharmacokinetics and toxicological
data on humans to verify its potential bioactive properties.
An Automatic Instrument Recognition Approach Based on Deep Convolutional Neural Network
Authors: Ke Jiangyan , Lin Rongchuan , Sharma Ashutosh
Published: March 2021

Background:

This paper presents an automatic instrument recognition method highlighting
the deep learning aspect of instrument identification in order to advance the automatic process
of video monitoring remotely equipment of substation.

Methods:

This work utilizes the Scale Invariant Feature Transform approach (SIFT) and the
Gaussian difference model for instrument positioning while proposing a design scheme of the instrument
identification system.

Results:

The experimental outcomes obtained proves that the proposed system is capable of automatically
recognizing a modest graphical interface and study independently while improving the
effectiveness of the appliance, thereby, realizing the purpose of spontaneous self-check. The proposed
approach is applicable for musical instrument recognition, and it provides 92% of the accuracy
rate, 87.5% precision value and recall rate of 91.2%.

Conclusion:

The comparative analysis with other state-of-the-art methods justifies that the proposed
deep learning-based music recognition method outperforms the other existing approaches in
terms of accuracy, thereby providing a practicable music instrument recognition solution.
Discovery of Potential Inhibitors of the Receptor-binding Domain (RBD)
of Pandemic Disease-causing SARS-CoV-2 Spike Glycoprotein from
Triphala Through Molecular Docking
Authors: Khan Sharuk L. , Siddiqui Falak A. , Shaikh Mohd Sayeed , Nema Nitin V. , Shaikh Aijaz A.
Published: March 2021

Background:

COVID-19 (SARS-CoV-2 infection) has affected almost every region of
the world. Presently, there is no defined line of treatment available for it. Triphala is already
proven to have a safe biological window, which is well known for its antioxidant and
immunomodulatory properties.

Objective:

The present work has been carried out to study Triphala's effectiveness in the treatment
of COVID-19.

Methods:

The Receptor-binding domain (RBD) of SARS-CoV-2 Spike Glycoprotein is responsible
for the invasion into the host cell, which leads to further infection. The molecular docking (MD)
was performed to explore the binding affinities (kcal/mol) of Triphala's chemical constituents and
compared them with the existing drugs under investigation for the treatment of COVID-19
epidemiology.

Results:

Chebulinic acid binding affinity -8.5 kcal/mol with the formation of 10 hydrogen bonds.
Almost all the major chemical constituents have formed two or more hydrogen bonds with RBD of
SARS-CoV-2 Spike Glycoprotein.

Conclusion:

The present study showed that Triphala might perform vital roles in the treatment of
COVID-19 and expand its usefulness to physicians to treat this illness. There is a need to complete
the in-vitro, in-vivo biological testing of Triphala on SARS-CoV-2 disease to create more quality
data. The binding mode of Chebulinic acid in the allosteric cavity allows a better understanding of
RBD of SARS-CoV-2 Spike Glycoprotein target and provides insight for the design of new
inhibitors. Triphala is already proven to have a safe biological window, which indicates that we
can skip the pre-clinical trials. Apart from this, Triphala is well known for its antioxidant
properties, which ultimately improve the immunity of the COVID-19 patient.
Mysterious Disease Strikes Andhra Pradesh, India- initial analysis of cases of an unknown disease (Preprint)
Authors: Mudgil Nidhi , Mishra Sidharth Sekhar , Pandey Anuj Kumar
Published: March 2021

UNSTRUCTURED

People from 3 districts of Andhra Pradesh, India were struck by a mysterious disease on Saturday December 05th, 2020. Epileptic like symptoms were present and most common differential diagnosis which can be made as of now is to classify them under Acute Encephalitis Syndrome (AES) or some form of heavy metal or insecticide poisoning affecting the Central Nervous System (CNS). To understand the reason behind the sudden illness blood tests, CT (brain) scans and Cerebral Spinal Fluid (CSF) tests were done on patients but all test reports have turned out to be normal.
Approximately 600 cases and 1 death are reported till 13th December 2020. Majority of the victims were in the 20- 30 years age groups. All the patients followed the same sequence of events having dizziness, headache, nausea, foam in mouth and epilepsy-like symptoms. Serological, viral markers and radiological findings along with COVID-19 reports were negative/ normal. Symptomatic management was provided, and patient recovered without any neurological abnormality. High levels of Lead and Nickel were found in the blood samples of some patients.
This is the first report as it provides preliminary findings of the mysterious disease. More information will provide further clarity about the outbreak
Medios de Control de la Legitimidad
Authors: Fernández de Lara García Salvador Alan
Published: March 2021

A través de un análisis objetivo, se propone la creación doctrinaria de los Medios de Control de la Legitimidad y se desglosan y explican los mecanismos que integran al novedoso concepto aludido. Para ello, se analizan a la legitimidad y a los medios de participación ciudadana; además de que se hace un listado de algunos mecanismos que son considerados como medios de control de la legitimidad, se definen y se explican.
La cooperación como forma de garantizar una respuesta integral a la trata de seres humanos.
Authors: Rodríguez Rodríguez Francisco Miguel
Published: March 2021

El texto analiza la necesidad de la cooperación internacional y sus aspectos más relevantes, así como los principales canales de cooperación disponibles que operan en la lucha contra la trata de seres humanos. Este delito suele tener un carácter transnacional, en el que las víctimas y los perpetradores pueden tener diferentes nacionalidades y actuar en diferentes países; por lo tanto, combatirla requiere la cooperación transnacional para el cumplimiento de la ley, y el establecimiento de canales de comunicación entre todos los países involucrados. La cooperación internacional se puede lograr mediante Equipos Conjuntos de Investigación (ECI), así como la implicación en dicha cooperación de Europol y de Eurojust, en la formación y funcionamientos de los Equipos Conjuntos de Investigación.
Igualdade e a proibição de discriminação: analise da proibição de ingresso de crianças em estabelecimentos abertos ao público
Authors: Cândido Lima e Silva Santos Regina
Published: March 2021

O artigo tem por objetivo analisar a licitude da a proibição de ingresso de crianças em estabelecimentos abertos ao público. Essa prática reflete uma tendência mundial denominada Childfree, termo que designa um movimento iniciado nos anos 70, nos Estados Unidos, com o intuito de agrupar adultos que não tinham filhos. A terminologia vem sendo utilizada para designar um nicho de mercado “só para adultos”. O objetivo do trabalho é analisar a conformidade da tendência Childfree com o direito fundamental à não-discriminação. Pretende-se averiguar se existem e quais são os limites à eficácia do princípio constitucional da igualdade nas relações contratuais, especificamente no que diz respeito à oferta pública de bens e serviços.
El ascenso de la extrema derecha en Brasil y la violación de los derechos humanos de los pueblos indígenas en Amazonia
Authors: Lunelli Isabella Cristina
Published: March 2021

De entre los múltiples factores responsables de los cambios socio espaciales en el territorio amazónico y que impactan los derechos humanos de los pueblos indígenas a principios de este siglo, la agencia del Estado brasileño sobre el territorio y sus recursos naturales no debe pasarse por alto, sobre todo teniendo en vista la llegada de la extrema derecha al poder ejecutivo federal de Brasil. En este sentido, este artículo explora la relación entre el ascenso de la extrema derecha conservadora en Brasil y la violación de los derechos humanos de los pueblos indígenas. Para tanto, analiza las principales articulaciones entre los discursos practicados por autoridades conservadoras, con el objetivo de demostrar cómo ciertos discursos anti-indígenas y anti-ambientalistas, que por mucho tiempo permanecieron latentes o incluso ocultos van siendo reciclados y actualizados, y sus implicaciones para los derechos humanos de los pueblos indígenas.
Mala Praxis Médica en el Derecho Penal Costarricense
Authors: Barrantes Baez Jose Alejandro
Published: March 2021

Para determinar la existencia de un ilícito por mala praxis médica, es preciso corroborar si se cumplen los requisitos objetivos (resultado dañoso) y subjetivos (falta al deber de cuidado) del tipo penal, así como un nexo de causalidad entre ambos. Todo ello, con la finalidad de determinar si se trata de un riesgo permitido en el arte médico o de un delito. Entonces, hasta en ese momento podría hablarse de una eventual responsabilidad por parte del personal médico, sea administrativa, penal o civil.
Cossío, José Ramón, Biografía judicial del 68. El uso político del derecho contra el movimiento estudiantil, México, Debate, 2020, 458 pp.
Authors: Jiménez Moreno Manuel De J.
Published: March 2021

Reseña de esta obra que trata sobre la dimensión judicial de los procesos a los presos políticos del 68.
Tratamiento moderno de la hemofilia y el desarrollo de terapias innovadoras
Authors: Ruiz-Sáez Arlette
Published: March 2021

La hemofilia es una enfermedad hemorrágica resultante de mutaciones en el gen del factor VIII (F8) de la coagulación en el caso de la hemofilia A o en el gen del factor IX (F9) en el caso de la hemofilia B, siendo ambas formas indistinguibles clínicamente. El fenotipo clínico usualmente refleja la actividad del factor en plasma y la principal complicación del tratamiento es el desarrollo de aloanticuerpos neutralizantes. El tratamiento moderno de la hemofilia comienza a despuntarse en la década de 1970 con la disponibilidad de concentrados de factores de la coagulación de origen plasmático, el inicio de programas de profilaxis y el manejo multidisciplinario de la condición. Posteriormente, la producción de concentrados seguros, debidamente inactivados o de origen recombinante, facilitó la individualización de la terapia y el desarrollo de los agentes baipás mejoró el tratamiento de pacientes con inhibidores. Para todas esas opciones, la gran limitante ha sido la necesidad de frecuentes infusiones endovenosas por un tiempo indefinido. La biotecnología ha permitido el desarrollo de concentrados de factor VIII y IX de vida media plasmática extendida y a la producción de terapias novedosas, diferentes a la terapia de remplazo, que mejoran la coagulación o inhiben las vías anticoagulantes naturales. Por último, los progresos en la terapia génica como potencial cura de la condición generan grandes expectativas. Si bien estos avances ofrecen alternativas terapéuticas para pacientes con o sin inhibidores, aún están por definirse aspectos relacionados a sus indicaciones, monitorización y seguridad a corto y largo plazo.
Efficacy of a Plant-Based Anti-Inflammatory Diet as Monotherapy in Psoriasis
Authors: Maldonado-Puebla Marigloria , Price Alexandra , Gonzalez Adrianna , Fuhrman Joel , Nichols Anna
Published: March 2021

Psoriasis is an immune-mediated disease associated with many comorbidities, including obesity, metabolic syndrome and cardiovascular disease. Many patients seek alternatives to standard treatments. In this case report, we present a non-obese patient who was able to completely clear her psoriatic plaques by following a plant-based, anti-inflammatory diet, focusing on the consumption of nutrient-dense foods. The efficacy of this anti-inflammatory diet may lie in the overall reduction of the systemic inflammatory state associated with psoriasis. Possible mechanisms of action are explored.
Treatment and Remission of Symptoms in Type 1 Diabetes with a Nutrient-Dense, Plant-Rich (NDPR) Diet: Case Studies
Authors: Fuhrman Joel H. , Ferreri Deana M.
Published: March 2021

Type 1diabetes (T1D), in contrast to type 2 diabetes, is an autoimmune disease rather than a lifestyle disease. However, diet and lifestyle factors such as nutrient density, glycemic load, fiber intake, and exercise do affect glycemic control, cardiovascular risk, and risk of complications in patients with type 1 diabetes. Patients with T1D may be able to reduce insulin requirements and achieve better glycemic control if practicing dietary methods to increase plant fibers and micronutrient density, and decrease glycemic load. We propose that anti-inflammatory effects of foods central to a nutrient-dense, plant-rich (NDPR) diet –vegetables, legumes, nuts and seeds, and lower-sugar fruits – may slow or prevent further destruction of beta cells if dietary intervention is initiated early enough. Herein, we present three cases of patients with T1D who have adopted a NDPR diet at varying times following T1D diagnosis. One patient who began a NDPR diet at age 3 immediately following diagnosis has not yet required insulin therapy nearly three years after diagnosis, and has experienced a steady decline in autoantibody levels. Another child who began a NDPR diet several months after diagnosis maintains a low dose of insulin, a favorable HbA1c, and more consistent blood glucose readings. A patient in his mid-40s who began a NDPR diet 13 years after T1D diagnosis, dramatically reduced insulin requirements and C-reactive protein and maintains favorable HbA1c and cardiovascular markers.
Benefit of One Week Immersion in Lifestyle-based Program for Sustainable Improvements in Cardiovascular Risk Factors Over Time
Authors: Schwartz Cody , Handberg Eileen , Pepine Carl , George Jerin , Jain Ankur , Desai Daya , Li Qian , Stoll Scott , Aggarwal Monica
Published: March 2021

BACKGROUND: Hypertension, hyperlipidemia, and obesity most commonly result from poor diet and lack of physical activity. Lifestyle measures for risk factor modification and cardiovascular disease (CVD) prevention include exercise and dietary changes but most people are not successful at initiating and/or maintaining meaningful changes. We propose that such changes can be initiated using a short-term, intensive “immersion” support approach.

METHODS: Moderate to high atherosclerotic CVD (ASCVD) risk individuals completed a 1-week, lifestyle-based immersion program, including daily nutrition education, 100% plant-based food consumption, exercise, and stress management classes. Beginning and end anthropomorphic measurements such as blood pressure and lipid measurements were collected. A dietary survey (14-point Mediterranean diet survey), functional capacity survey (Duke Activity Status Index [DASI] survey), and quality of life (QOL) survey (Sf-36), were administered on Day 0 and 3 months post-immersion.

RESULTS: Eighty participants completed the program; 64% women, mean age 47 years (range 21-71), mean weight 88.43 kg (range 45.4-131.3 kg) and mean body mass index (BMI) 30.47 kg/m2 (range 18.6-44.8 kg/m2). Of the participants, 71% had hypertension (HtN), 39% had HbA1c ≥ 5.7%, 35% were former smokers, and 7.5% were active smokers. Average ASCVD risk was 6.84% (range 0.3-39%). After 1 week of the immersion program, BMI decreased on average 0.5 ± 0.38 kg/m2, weight decreased on average 11.49±1.19 kg (both p<0.001). Systolic blood pressures (SBP) decreased on average 6.76±15.17 mmHg and diastolic blood pressure (DBP) decreased on average 5.00±9.82 mmHg (both p<0.001). total cholesterol decreased on average 20.40 ± 15.44 mg/dL, triglycerides decreased on average 31.78 ± 44.06 mg/dL, LDL decreased on average 11.71 ± 15.92 mg/dL (all p < 0.001). High-density lipoprotein (HDL) also decreased on average 3.13 ± 5.83 mg/dL (p < 0.001). Sixty participants with diagnosed HtN or prescribed antihypertensive medications saw decreases in both SBP and DBP. In the majority of participants, improvements in functional capacity, QOL, and dietary compliance were noted.

CONCLUSIONS: Short-term, intensive lifestyle intervention is feasible, can lead to immediate improvements in risk profiles, and, importantly, can have longer-lasting effects on exercise capacity, dietary compliance, and QOL.
Harmony
Authors: Ngo Nealie Tan
Published: March 2021

The human body is a vessel harboring all of the decisions we make on a day-to-day basis. Similarly, our environment is a vessel imprinted with all of the consequential actions of humankind. The relationships between body and environment, and between physician and patient are harmonious. The actions of just one affect all of the others, and vice versa. Finding a balance for a healthy relationship between both vessels lies in prevention.
An Orthopaedic Surgeon’s Belated Path to a Vegan Diet
Authors: Farris Clyde Alan
Published: March 2021

Article about the experience of an Orthopaedic surgeon transitioning to a vegan diet as an adjunctive measure for prostate cancer management.
Case Study: Water-Only Fasting and an Exclusively Whole Plant Foods Diet in the Management of Psoriatic Arthritis
Authors: Frey Asa Reuben , Frey Joanna
Published: March 2021

Psoriatic Arthritis (PsA) is a unique form of inflammatory arthritis associated with psoriasis. The current pharmacological management approach to treating PsA is often not successful in isolation. Here, the case of a 46-year-old woman with PsA is presented. The patient underwent a medically supervised, water-only fast and began an exclusively whole plant foods diet free of added sugar, oil, and salt. The patient discontinued the use of corticosteroids and achieved a significant reduction and eventual elimination of PsA symptoms. This case demonstrates the need for further research on the effects of medically supervised water-only fasting in cases of psoriatic arthritis.
Whole Food Plant-Based Diet as a Treatment of Recurrent Atrial Fibrillation Following Catheter Ablation
Authors: Schleifer John W , Dhawan R.
Published: March 2021

Atrial fibrillation (af) may recur despite antiarrhythmic drug therapy or catheter ablation. is case reports such a scenario of a patient with recurrent paroxysms of af following catheter ablation that resolved following institution of a whole-food, plant-based diet. us, a change to a whole-food, plant-based diet may be an effective intervention for reducing or eliminating af recurrence.
The Importance of a Healthy Lifestyle in the Era of COVID-19
Authors: Petersen Kristina S. , Freeman Andrew M. , Kris-Etherton Penny M. , Williams Sr. Kim Allan , Reddy Koushik R. , Aggarwal Monica , Barnard Neal D. , Ornish Dean , Esselstyn Jr. Caldwell B. , Allen Kathleen , Aspry Karen
Published: March 2021

Existing cardiovascular disease (CVD) and its modifiable risk factors are associated with increased mortality from coronavirus 2019 (COVID-19). Clinical attention has focused on acute interventions for COVID-19, but reducing upstream risks associated with poor outcomes must occur in parallel. This is particularly urgent because risk factors for COVID-19 death are prevalent, and the pandemic has negatively impacted lifestyle and socioeconomic factors that augment these risks. Evidence-based lifestyle interventions have a generally short time-to-benefit, and lower risk of CVD and improve markers of immune function. Wider promotion of healthy lifestyle practices will improve the CVD health of the population and could favorably impact COVID-19 outcomes. Research examining how lifestyle modification affects COVID-19 susceptibility and severity is urgently needed.
Representação Social da obesidade: análise com estudantes do ensino médio e universitários
Authors: De Sousa Bezerra de Menezes Thais , Carneiro Maciel Silvana , Faro Santos André , Lourenço da Silva Larissa , Vasconcelos Dias Camila Cristina
Published: March 2021

O objetivo deste estudo foi analisar e comparar as Representações Sociais elaboradas por estudantes do ensino médio e universitários frente à obesidade. Participaram do estudo 200 estudantes do ensino médio de escolas públicas e privadas e 200 universitários de universidade de João Pessoa, Brasil. Os instrumentos utilizados foram: questionário sociodemográfico, analisado através de estatísticas descritivas realizadas no software SPSS e Técnica de Associação Livre de Palavras a partir do estímulo “obesidade”, analisado por meio de Análise Prototípica no software IRAMUTEQ. A análise revelou elementos comuns nos núcleos centrais dessas representações que evidenciam uma concepção unifatorial em relação às causas da obesidade, relacionando-a principalmente à má alimentação, sem considerar consistentemente os aspectos psicossociais associados, o que pode levar à culpabilização e ao preconceito. Espera-se com este trabalho estimular estudos futuros e intervenções que apresentem informações acuradas sobre a obesidade e possam diminuir o preconceito em relação às pessoas obesas.