bluuebunny/crossref_metadata_2025 huggingface dataset:
Enkele teologiese uitdagings rakende diakonia in van die Afrikaanse Suid-Afrikaanse kerke
Authors: Knoetze Johannes J.
Published: March 2023

This article attends to the theological foundation of the diaconate from the missio trinitatis Dei and its implications, especially for the Afrikaans-speaking Reformed churches. The missio Dei, of the Father, Son, and Spirit is directed at the realities of this life. The new heaven and the new earth are not mutually exclusive. The earth is sanctified anew, man has created anew [recreated], and our bodies are raised anew [revived]. This new earth, a new man, and new life come through the merciful dikaiosune of the Father, the diakonia of the Son, and the koinonia of the Holy Spirit. The diaconate and the missionary ministry of the church are caught in the essence of God and therefore belong to the essence of missionary ecclesiology. From the trinitarian perspective, the purpose of the diaconate is described as well as the relationship between the diaconate, the church, and the kingdom. The last part of the article deals with salvation and diaconate and the implications of a trinitarian understanding of the diaconate for the understanding of salvation.Intradisciplinary and/or interdisciplinary implications: This article makes an interdisciplinary contribution to the theological discussion within the Afrikaans-speaking churches from the perspective of systematic and practical theology.
Overview of the National Cancer Screening Program for Colorectal Cancer in Korea over 14 Years (2004-2017)
Authors: Park Bomi , Her Eun Young , Lee Kyeongmin , Nari Fatima , Jun Jae Kwan , Choi Kui Son , Suh Mina
Published: March 2023

Purpose This study aimed to evaluate the participation and follow-up test compliance rates and key performance indicators of the National Cancer Screening Program (NCSP) for colorectal cancer (CRC) from 2004 to 2017.Materials and Methods The overall outcomes of the NCSP for CRC were analyzed using the NCSP data collected from 2004 to 2017 and the Korean Central Cancer Registry for CRC from 2005 to 2017. We cross-sectionally analyzed the participation and follow-up test compliance rates and performance indicators for each year. The trend of participation rates as an annual percentage change was assessed, and other statistical analyses were performed.Results The screening participation rates increased from 7.3% in 2004 to 30.5% in 2017. Additionally, the screening rates were higher among individuals aged 60-69 years and National Health Insurance Service beneficiaries of low-income status. However, the adherence to the follow-up test decreased from 63% in 2004 to 32% in 2017. The follow-up tests using the double-contrast barium enema method decreased from 42.2% in 2004 to 0.3% in 2017. However, follow-up tests by colonoscopy increased from 21.0% in 2004 to 31.8% in 2017. Furthermore, the positivity, false-positive, and interval CRC rates decreased, whereas the specificity increased from 2004 to 2016, indicating improved performance of CRC.Conclusion The participation rates and performance of the NCSP for CRC have steadily improved, whereas adherence to follow-up tests has decreased. Additionally, there is a rapid growth in colonoscopy volume as a follow-up test. Continued efforts are required to improve the follow-up rates.
Etiquetas de sostenibilidad espontáneas: exploración de un objeto jurídico no identificado
Authors: Villablanca Lusitania Raquel del Carmen
Published: March 2023

Las etiquetas de sostenibilidad espontáneas responden a preocupaciones que se masifican entre los consumidores: Empresas B, bienestar animal, etc. Este fenómeno engendra una “industria certificadora” sometida a un mínimo de regulación, que impide que las etiquetas cumplan su objetivo: garantizar los elementos certificados. Para demostrarlo explicaremos su funcionamiento, comparándolo con el régimen de las etiquetas reguladas. El texto plantea los conceptos jurídicos fundamentales que nos permitan, luego, examinar su tratamiento por el derecho del consumo.
La entidad como límite al daño moral en el contrato médico
Authors: Loayza Mosqueira Boris
Published: March 2023

El presente comentario tiene por objeto la sentencia de Corte Suprema de 24 de enero de 2019, caratulada Natalia Parra Vásquez y otra con Laboratorio Clínico Cheul Etcheverry, en la cual se estableció que el verdadero límite del daño moral en un contrato de prestación de servicios médicos es la entidad del daño y no, en cambio, el ámbito de protección del contrato, el que, en este tipo de acuerdos, entrega una solución incompleta.Si bien lo expuesto por la Corte Suprema es acertado, queda aún algo pendiente: la determinación de los criterios mediante los que se puede establecer que ciertas molestias constituyen, o no, un daño moral indemnizable, es decir, que tienen cierta entidad. En mi opinión, los criterios son, entre otros, el impacto del diagnóstico médico y el lapso de tiempo.
La falsedad documental de notarios regulada en el artículo 443 del Código Orgánico de Tribunales: análisis dogmático y crítico
Authors: Mayer Lux Laura
Published: March 2023

El presente trabajo tiene por objeto analizar los elementos y valorar críticamente la regulación del delito establecido en el artículo 443 del Código Orgánico de Tribunales. Utilizando una metodología fundamentalmente dogmática, el texto menciona los antecedentes históricos del delito y examina la técnica legislativa utilizada para describirlo. Asimismo, analiza los aspectos objetivos y subjetivos del tipo, destacando varios problemas que genera su actual regulación, especialmente desde un punto de vista sistemático y valora
Derrotabilidad y razonamiento jurídico en disputa: reconstrucción y proyecciones del (no) debate Alexy-García Amado
Authors: Espinosa Aguilar Marcelo
Published: March 2023

El propósito del presente trabajo es proporcionar una reconstrucción argumental de los postulados de Robert Alexy y Juan Antonio García Amado sobre la derrotabilidad normativa. En miras a tal cometido, se expondrán sistemática y someramente los cimientos teóricos de cada uno de los autores para posteriormente explicitar su específica tesis sobre el particular. Finalmente, se realizará un análisis crítico del debate y sus principales proyecciones, demostrando la prosperidad de las críticas de García Amado y, consecuentemente, las ventajas de su teoría de la derrotabilidad por sobre la de Alexy.
Problemas seleccionados del delito de violación con homicidio
Authors: Escobar Veas Javier
Published: March 2023

El presente artículo tiene por finalidad analizar las principales cuestiones problemáticas que plantea el delito de violación con homicidio, previsto y sancionado en el artículo 372 bis del Código Penal chileno. En este contexto, se revisarán tanto sus exigencias objetivas como subjetivas, colocando especial énfasis en el vínculo que debe existir entre el delito de violación y el de homicidio, exigencia representada por la expresión “con ocasión”, así como en el problema relativo a la posibilidad de aplicar, respecto del delito en estudio, las normas generales sobre iter criminis.
¿Derribar un avión actuando en estado de necesidad? Los límites de la dogmática penal y la necesidad de analizar dilemas morales mediante la ética normativa
Authors: Beade Gustavo A.
Published: March 2023

En este trabajo pretendo vincular la discusión académica sobre algunos aspectos del terrorismo, en especial, la controversia suscitada por una de las normas nacidas luego del recordado 11 de septiembre de 2001, la Ley de Seguridad Aérea alemana (Luftsicherheitsgesetz/ LuftSiG) con problemas vinculados a la filosofía moral. Me tomar como ejemplo a este caso para mostrar que normas como ésta, son difíciles de aceptar o rechazar sin tomar determinadas decisiones morales previas. Intentaré plantear una objeción a quienes interpretan estas normas y sus prácticas i.e., derribar un avión para evitar que colisione contra la población civil, exclusivamente a partir de una interpretación jurídico-penal. Mi objeción se basa en que estas y otras situaciones particulares dependen de una respuesta moral, que en muchos casos el derecho penal no tiene, o no hace explícita. En el caso de la Ley de Seguridad Aérea (en adelante LuftSiG) depende, concretamente, de una difícil decisión de ética normativa.
A note on weight systems which are quantum states
Authors: Collari Carlo
Published: March 2023

A result of Corfield, Sati, and Schreiber asserts that
$\mathfrak {gl}_{n}$
-weight systems associated with the defining representation are quantum states. In this short note, we extend this result to all
$\mathfrak {gl}_{n}$
-weight systems corresponding to labeling by symmetric and exterior powers of the defining representation.
The error term in the truncated Perron formula for the logarithm of an L-function
Authors: Garcia Stephan Ramon , Lagarias Jeffrey , Lee Ethan Simpson
Published: March 2023

We improve upon the traditional error term in the truncated Perron formula for the logarithm of an L-function. All our constants are explicit.
Middle School Mathematics Teachers' Reasoning about Students' Nonstandard Strategies: Division of Fractions
Authors: Tekin-Sitrava Reyhan
Published: March 2023

Although students' nonstandard strategies have great importance in understanding students' thinking and creating effective mathematics classrooms, much remains unexplored in the literature. This study investigated 22 middle school teachers' reasoning about a student's nonstandard strategy for the division of fractions. The data were collected through semi-structured interviews and a task consisting of a student's nonstandard strategy within a classroom excerpt which simulates how mathematical work emerges in the context of teaching. Six categories of layers were formed based on their reasoning about the validity, generalizability, and efficiency of the nonstandard strategy. These layers were categorized as a surface, intermediate, and deep level of reasoning. It was found that while half of the teachers had a surface level of reasoning, only one-third of teachers are at a deep layer of reasoning. On the other hand, teachers' reasoning approaches of how and when the nonstandard strategy works for all problems were determined as equating the answer, equating the process, being multiples of each other, and equating the denominators. The results and implications are discussed, and recommendations are presented in accordance with the findings of the study.
Preservice Teachers' Understanding of 'Real world': Developing a Typology
Authors: Simic-Muller Ksenija , Fernandes Anthony
Published: March 2023

This study examines the beliefs of 33 preservice teachers (PSTs) from the U.S. have about using different types of real-world contexts in the mathematics classroom. Qualitative data about the participants' reactions to specially designed word problems that varied in contexts from 'neutral' to controversial were collected. A thematic analysis of the responses indicated that they could be arranged into three typologies on a continuum based on their openness towards the use of controversial issues in the mathematics classroom. Drawing on the analysis of PSTs' responses and the literature, a fourth typology was inferred. The typologies can be useful to teacher educators and education programs as they seek to prepare PSTs to work with increasingly diverse students in their future mathematics classes. The study also highlights the potential of using word problems as a tool to understand PSTs' beliefs.
Exploring Secondary Mathematics Teachers' Conceptions of the Barriers to Mathematical Literacy Development
Authors: Genc Murat , Erbas Ayhan Kursat
Published: March 2023

The purpose of this study was to investigate secondary mathematics teachers' conceptions of the barriers to the development of mathematical literacy. The data were collected through semi-structured interviews with sixteen in-service mathematics teachers from nine secondary schools of five different school types. The data analysis consisted of an inductive analysis process for identifying and labeling the patterns or themes through examining interview data with the help of NVivo qualitative data analysis software. The results indicated that teachers' conceptions regarding the barriers to mathematical literacy development could be categorized under: (i) conceptual challenges (What is mathematical literacy?); (ii) educational challenges (How can we develop mathematical literacy?); and (iii) systemic challenges (Where is mathematical literacy (to be) located?). The teachers' identification of different obstacles to the development of mathematical literacy can account for the fact that each teacher in this study has diverse but convergent conceptions of mathematical literacy. This fact also promises hope for assisting teachers in resolving these obstacles that have been raised from various angles.
Innovación, financiamiento y gestión empresarial, factores que determinan la resiliencia de las Mipymes. Un modelo explicativo con ecuaciones estructurales
Authors: Molina-Sánchez Rubén , López-Salazar Alejandra , López-Salazar Gloria Leticia
Published: March 2023

Las condiciones actuales obligan a las Mipymes a mejorar su capacidad de adaptación con la intención de mejorar su desempeño y lograr posicionarse en el mercado con mayor facilidad. El objetivo del presente artículo es comprobar si la gestión empresarial, la innovación y el acceso al financiamiento impactan en la resiliencia empresarial. El método de investigación utilizado es cuantitativo y se utiliza como procedimiento estadístico la modelización de ecuaciones estructurales, con una muestra de 1416 Mipymes del estado de Guanajuato, México. Los resultados confirman que la gestión empresarial, la innovación y el acceso al financiamiento influyen de manera positiva y significativa en la resiliencia de las Mipymes. Las futuras investigaciones deben centrarse en incorporar nuevos factores que influyen en la resiliencia empresarial.
Estrategias aplicadas durante la pandemia bajo el entorno VUCA en empresas de Guanajuato, México
Authors: Ruiz-Domínguez Verónica Esperanza ,   Universidad Politécnica de Guanajuato, Álvarez-Orozco Dolores Guadalupe , Durán-Alejo Paola Michelle ,   Universidad Politécnica de Guanajuato
Published: March 2023

La pandemia por COVID-19 ha generado grandes desafíos para la gran mayoría de las organizaciones, independientemente de su tamaño, giro o situación financiera, los ambientes con los que interactúa actualmente se han transformado más Volátiles, Inciertos, Complejos y Ambiguos (VUCA). El objetivo del presente proyecto es identificar las estrategias en un entorno VUCA aplicadas en post-pandemia en empresas de Guanajuato. En esta investigación se utilizó una metodología de enfoque cualitativo, con marco referencial fenomenológico, la muestra aplicada fue a 25 empresas en el periodo 2021-2022 en el estado de Guanajuato. Los resultados que se obtuvieron indican que, en general, los entrevistados mencionaron que sus problemáticas estuvieron relacionadas con la cadena de suministro y disminución de ventas provocados por la pandemia por COVID-19. Las estrategias aplicadas fueron encaminadas hacia los procesos, capital humano, compras, ventas, gestión y de salud. Siendo las estrategias orientadas a gestionar el capital humano las más recurrentes, y dentro de esta las estrategias que más se aplicó fue el home office para el personal administrativo, seguida por el cambio de estrategias de comunicación, también se encontró que fueron escasas las coincidencias de las estrategias implementadas por las empresas y las sugeridas por los teóricos para ambientes VUCA.
La Digitalización de las MiPyMEs : caso de estudio Guanajuato-Jalisco
Authors: Tiburcio-Sánchez María de Lourdes , Lozano-Montero Eva , Godínez-López Roberto
Published: March 2023

La digitalización de las empresas, principalmente de las grandes, era inexorable, aunque con la contingencia sanitaria que se enfrentó a nivel mundial, obligó a las micro, pequeñas y medianas empresas (MiPyMEs) a su transformación digital, en donde no solamente se requería de inversión o de infraestructura para poder permanecer en el mercado, era necesaria una transformación organizacional y de cultura, por lo que a través de un estudio de caso con un enfoque cualitativo definido como  J. Creswell, se estudia cómo dos microempresas inician la implementación de transformación digital. Los resultados indican que el análisis PESTEL apoya en la identificación de amenazas y oportunidades en el entorno, las MiPyMEs observaron un incremento de ventas y las herramientas que principalmente se utilizaron en el proceso de la digitalización fueron el comercio digital y el marketing digital, además de material para el registro de las marcas que se encuentra en el Instituto Mexicano de la propiedad industrial (IMPI).Fue de gran relevancia concientizar a los responsables de las MiPyMEs respecto a la importancia de reconocer cuál era el modelo de negocio, identificando el perfil de sus clientes para establecer contactos más adecuados. La metodología utilizada es una hoja de ruta para la digitalización, hasta llegar al uso intensivo de las Tecnologías de la información.
El impacto de La actividad innovadora y la mercadotecnia en la competitividad de Las MIPYMES De la Confección Del Vestido De Moroleón, Guanajuato, México
Authors: Zavala-Villagómez Patricia , Aguilasocho-Montoya Dora , De la Torre-Torres Oscar Valdemar
Published: March 2023

El objetivo de esta investigación es conocer el grado de correlación entre el marketing y la innovación con la competitividad de la industria de la confección del vestido (MIPYMES) de Moroleón, Guanajuato, México en situación de pandemia. El estudio consistió en una investigación cuantitativa de tipo descriptivo y corte trasversal, se realizó un muestreo probabilístico aleatorio estratificado con afijación proporcional con  95% de confiabilidad, dando como resultado una muestra de 273 empresas segmentadas en medianas (0.32%), pequeñas (3.52%) y microempresas (96.15%), a las cuales se les aplicó un instrumento de medición a escala Likert, los datos obtenidos fueron sometidos a un análisis estadístico de Spearman y a un examen de comprobación mediante un análisis de reducción de dimensiones con la prueba de KMO y la prueba de esfericidad de Bartlett, con lo que pudimos comprobar de manera positiva la hipótesis de investigación.
SOSTENIBILIDAD ECONÓMICA PRE-COVID Y POST-COVID DE LOS CENTROS ESPECIALES DE EMPLEO EN ESPAÑA
Authors: Gómez-González Elisabet , Cano-Montero Elisa Isabel , Santos-Peñalver Jesús Fernando
Published: March 2023

Los Centros Especiales de Empleo (CEEs) son una oportunidad de integración en el mercado laboral de personas con discapacidad en distintos sectores de actividad. Existen pocos estudios en España en los que se desagreguen estas empresas por sectores. Por tanto, el objetivo principal de este trabajo es estudiar la sostenibilidad económica de 662 centros especiales de empleo para el período 2014-2020, agrupadas por sectores de actividad en base a la rentabilidad económica y financiera, así como analizar la respuesta de los CEEs ante la crisis de la Covid-19. Se realiza un estudio exploratorio aplicando una metodología cuantitativa. A la vista de los resultados, comprobamos que estas empresas predominan principalmente en Andalucía, Madrid, Castilla y León y Cataluña. Además, vemos que prevalecen en el sector servicios, predominan las sociedades limitadas, son sostenibles económicamente y se han visto afectadas por la crisis de la Covid-19, aunque no todos los sectores de igual forma.
Karacadağ/Baruttepe (Diyarbakır) Çevresinin Jeomiras ve Jeoturizm Özellikleri
Authors: ŞENGÜN M. Taner , KILIÇARSLAN Muhammed , GÖKTAŞ Yaren
Published: March 2023

Türkiye’de Güneydoğu Anadolu Bölgesi’nin ortalarında bir kalkan tipli (Hawaii) volkan olan Karacadağ bulunmaktadır. Karacadağ volkanının son evre volkanitlerinden olan Baruttepe konisi, Karacadağ’ın en genç lavlarını meydana getirmiştir. Baruttepe ve çevresinde meydana gelen farklı morfolojik süreçlerle beraber bir çok volkan morfolojisi şekli oluşmuştur. Yalnızca bazı volkanik arazilerde gözlemlenen bu şekiller, nadir olarak görülen coğrafi şekiller olması sebebiyle jeomiras ve jeoturizm açısından önem arz etmektedirler. Araştırmamıza konu olan Baruttepe konisi ve çevresindeki jeomiras unsurlar, Diyarbakır ili Çınar ilçesi sınırlarında yer almakta olup Diyarbakır il merkezinin güneybatısında, Karacadağ volkanik kütlesinin doğu eteklerinde yayılış göstermektedir. Baruttepe konisi, Kuvaterner yaşlı bazaltik bir volkan konisi olup buradan ve çevresindeki diğer küçük çıkış merkezlerinden çıkan lavlar doğu yönünde 25-30 km kadar akış göstermiştir. Yaklaşık 120 km²’lik bir sahaya yayılış gösteren bu lavlar üzerinde başta birçok lav tüneli olmak üzere; lav akıntısı kırışıklıkları, lav kanalları, halat tipi lavlar, küçük çaplı basınç sırtları, leçeler ve tavanı çökmüş lav tüneli gibi çeşitli volkanik şekiller oluşmuştur. Çeşitli büyüklüklerde birçok lav tünelinin olduğu bu saha eşine az rastlanır doğal güzellikleri ve ilgi çekici oluşumlarıyla önemli bir jeoturizm potansiyeli barındırmaktadır. Araştırma kapsamında detaylı bir literatür taraması yapılmış olup Baruttepe Konisi ve yakın çevresindeki jeomiras unsurlarıyla ilgili geniş çaplı bir bilimsel çalışmaya rastlanmamıştır. Bu doğrultuda araştırmanın amacı Baruttepe konisinin ve yakın çevresindeki jeomiras unsurlarının oluşum ve gelişim süreçlerini açıklamak ve jeoturizm potansiyellerini değerlendirip söz konusu sahanın literatüre kazandırılmasına katkı sağlamaktır. Yapılan arazi çalışmalarıyla sahada; piroklastik koni, krater, lav tüneli, tavanı çökmüş lav tüneli, lav kanalı, halat tipi lav akıntısı, lav kemeri ve leçelik arazi gibi farklı ölçeklerde ve birçok sayıda jeomiras unsuru ortaya konmuştur. Tespit edilen bu jeomiras unsurlarının genel özellikleri ve oluşum süreçleri hakkında bilgi verilerek jeoturizm potansiyelleri değerlendirilmiştir. Bu araştırma ile elde edilen sonuçlar; Baruttepe konisi ve yakın çevresindeki jeomiras unsurlarının belirlenmesine, sürdürülebilir turistik altyapının oluşturulması için gerekli planlamaların yapılmasına ve çevresinin turizm değeri kazanması sürecine katkı sunacaktır.
Analisis Performa Alat Bantu Pendaratan DVOR VB-53D dengan Ketepatan Periodisasi Kalibrasi pada Masa Pandemi COVID-19 di Airnav Cabang Batam
Authors: Fatiha Hana
Published: March 2023

Untuk menjaga kinerja fasilitas komunikasi dan fasilitas pelayanan pendaratan tetap laik operasi, maka fasilitas komunikasi dan pelayanan pendaratan seperti DVOR harus dikalibrasi secara berkala. Cara mengetahui baiknya performa fasilitas navigasi penerbangan untuk membantu pendaratan dengan cara melakukan ground inspection maupun flight inspection. Dirjen Hubud bersama dengan operator dan Otoritas Bandara telah melaksanakan koordinasi untuk mencegah penyebaran COVID-19 meliputi pembatasan aktivitas bagi pengguna, transportasi udara serta aktivitas teknisi dalam melaksanakan pemeliharaan dengan melakukan ground inspection. Pengujian di darat atau ground inspection dapat menjadi alternatif perpanjangan saat kalibrasi tidak dilakukan namun pada pelaksanaan kalibrasi ada beberapa parameter yang tidak bisa dilakukan pada ground inspection dan terdapat beberapa kemungkinan yang terjadi jika kalibrasi tidak dilaksanakan tepat waktu. Maka dilakukan survei dan pengolahan data menggunakan aplikasi SPSS, performa peralatan DVOR dapat dilihat dari hasil pengolahan data.
An Evaluation of Redefining Education with Industry 4.0
Authors: George Abin , Navya Gandhavalla
Published: March 2023

In recent years, a new industrial paradigm known as Industry 4.0 has begun to trend in emerging technologies in the world, helping to bridge the gap between humans and machines in ways that can only be imagined in science fiction books. This technology is rapidly gaining traction in different parts of the world as a potential tool that can maximize corporate productivity, contribute to scientific growth, enrich a country's economy, and improve people's quality of life. This paper describes the concepts of the implementation of Industry 4.0 to redefine education in India. This study aims to identify the possible uses of Industry 4.0 technologies in the area of education and how they can be utilized to facilitate learning. The question is raised on why the Indian education system needs to implement Industry 4.0. A literature study method and a SWOT analysis were used in this study. The results show that it can help to achieve personalized learning, smart classrooms, Data analytics, collaborative learning, and learning management systems. Industry 4.0 has the potential to transform education in India by providing new tools and methods for teaching and learning that can enhance the quality and effectiveness of education.
Work Accidents and Coal Mining in Turkey
Authors: Çınar Ibrahim , Şensöğüt Cem
Published: March 2023

In this study, an up-to-date evaluation of work accidents and occupational diseases in hard coal and lignitemining in Turkey has been made using the Social Security Institution (SSI) of Turkey statistics between 2013-and2020. For this purpose, the number of insured employees who had work accidents and occupational diseases, thenumber of insured people who lost their lives as a result of work accidents, and the total temporary incapacity for work(standing + inpatient) were examined. Although the number of people who had work accidents, the number of deathsafter work accidents, and the total duration of temporary incapacity in the lignite mining field of activity are higher thanin the field of activity in hard coal mining, it is seen that the number of occupational diseases is lower.
Content of vol. 6, 2014, Journal Scientific and Applied Research
Authors:   Konstantin Preslavsky University of Shumen, Faculty of Technical Sciences, Boyanov Petar
Published: March 2023

Content of vol. 6, 2014, Journal Scientific and Applied Research
17-YEAR PERIODS OF RISING AND FALLING WATER LEVELS IN THE KAZAKHSTAN SECTION OF THE CASPIAN SEA
Authors:   KAZAKHSTAN NATIONAL AGRARIAN INSTITUTE, 8 ABAYA, KAZAKHSTAN ADDRESS: 050010 ALMATY, 8 ABAYA, KAZAKHSTAN, Suleimenova Nazia , Kenzhetayev Gusman ,   S. YESENOV CASPIAN STATE UNIVERSITY, KAZAKHSTAN NEIGHBOURHOOD 31, AKTAU, Syrlybekkyzy Samal ,   KAZAKHSTAN NATIONAL AGRARIAN INSTITUTE, 8 ABAYA, KAZAKHSTAN ADDRESS: 050010 ALMATY, 8 ABAYA, KAZAKHSTAN
Published: March 2023

The Caspian is the largest endorheic lake on Earth, situated on the boundary of Europe and Asia, yet it is called a sea due to its sheer size and its seabed that has been formed by oceanic Earth crust. The Caspian Sea has a fluctuating hydrologic regime that causes both sharp drops and sudden increases in its water level. The present article examines the specifics of the relief of the sea floor in the Kazakhstan section of the Northern Caspian which is the most susceptible to underflooding (due to a rise in the water table) during water surges. This article analyses the dynamics of the fluctuating water levels in the Caspian Sea during the period of decreased and increased water levels from 1960 to 2013. It also offers the possible reasons for these changes in the water levels of the Caspian Sea.
Development and in-vitro evaluation of Etoricoxib loaded Transdermal Film containing MWCNT
Authors: Rabinarayan Parhi
Published: March 2023

Nanocomposites are materials that integrate either a unit of nanoscale material or multi-units of nanoscale material into a matrix of a standard substance. The main purpose of the current study is to fabricate and evaluate nanocomposite transdermal films of Etoricoxib. The transdermal films of etoricoxib were developed with a mixture of polymers viz. Eudragit RL-100 and HPMC K4M, with or without different percentages of multi-walled carbon nanotubes (MWCNT, 1, 3, 5, and 10%, w/w of total polymer) using solvent casting method. Various parameters including FT-IR, DSC, drug content, folding endurance, moisture content, moisture uptake, water vapour permeability (WVP), and in-vitro drug release employing Franz diffusion cell were assessed for the prepared films. The absence of interaction between the drug and polymers was confirmed by FT-IR and DSC studies. The thickness of the resulted films was within the range of 0.33±2.76 µm to 0.43±2.76 µm. The weights of prepared films were between 85.1±1.3 mg to 85.15±0.8 mg. The drug content was measured to be between 4.486 and 5.993 mg. The folding endurance of the developed films ranged from 237.33±7.8 to 342±6.5. The moisture content (%) was between 5.91 ± 1.2% and 8.84 ± 4.0%, whereas the percent moisture uptake of prepared films was observed to be between 8.23 ± 2.1% and 12.38 ±3.6%. The WVP of films was found to be 97.08 ± 0.57 g/m2/day to 194.17 ± 0.81 g/m2/day. In-vitro release studies revealed that formulation F4 prepared with an equal amount (50:50) of Eudragit RL-100 and HPMC K4M, and 5% MWCNT shows the highest drug release after 24 hr of study.The above results imply that the nanocomposite films could be an effective tool for transdermal delivery of etoricoxib and could act as a better prospect in replacing the oral dosage form.
In Vitro Studies on Binary Mixture of Skimmed Milk and Urea as Solid Dispersion Carrier for Aceclofenac
Authors: Sarkar Prasenjit , Das Saumyajyoti , Majee Sutapa Biswas
Published: March 2023

Among the various strategies employed to enhance solubility, dissolution and bioavailability of poorly soluble drugs in vivo, formulation of solid dispersion using hydrophilic and/or water-soluble carriers with varying physicochemical characteristics seems to be a developable, economically viable and easy option. The present study is aimed to use skimmed milk(SKM)-urea(U) as a novel binary mixture of classical carrier-hydrotrope in solid dispersion of poorly water-soluble aceclofenac (ACF). Compatibility of ACF and binary mixture of SKM-U was confirmed by FTIR spectroscopic analysis. Solid dispersions of ACF-SKM and ACF-SKM-U were prepared in varying ratios of 1:1 to 1: 5 for ACF-SKM and 1:4.5:0.5, 1:4.25:0.75 and 1:4:1 for ACF-SKM-U by solvent evaporation technique using ethanol(95%) as the common solvent and were characterised by their physical appearance, solubility enhancement (compared to pure drug) in double distilled water and phosphate buffer (pH 6.8) at 25 ⁰C and drug dissolution profiles in the above mentioned media. Based on solubility enhancement data(71.53%  and 31.03%) and maximum cumulative percentage release data (82.37% in 9 mins and 68.03% in 90 secs ) in double distilled water and phosphate buffer respectively, ACF-SKM (1:5) was found to the best which was used for studying the effect of addition of urea as hydrotrope. ACF: SKM: U (1 : 4.5 : 0.75) exhibited maximum solubility enhancement of 75% .and 36.51% and cumulative percentage release of 83.83 % in 9 mins and 69.24% in 90 secs in double distilled water and  buffer respectively. Therefore, the binary mixture of skimmed milk-urea has been proved to be marginally superior over skimmed milk in terms of solubility enhancement and drug release profile of aceclofenac.
Case report on clinical effect of Khadir compound drug (Kitibha har kashay)inPsoriasis and its cell line study
Authors: Chauhan Gouri , Shiwangee  , Kumar Kamlesh , O.P. Singh
Published: March 2023

Psoriasis is a common skin disease which is inflammatory, proliferative, autoimmune, and chronic with relapsing nature. It resembles with Kitibha Kustha roga ofAyurveda which is described asrelapsing disease with dry, rough, discolored skin lesions. This is a case report of psoriasis patientwho was treated conservatively with Kitibha har kashay for 3 months. The assessment of clinical improvement was made, along with the biochemical profiling and photographic analysis. Patient was also instructed to follow the do’s and don’ts of the disease for diet and lifestyle also called pathya and apthya. Parameters that were used to assess the clinical improvement were PASI score, IGA scale and grading of Ayurvedicclinical symptoms of Kitibha.The patient was given the medication prepared from the AyurvedicPharmacy, Faculty of Ayurveda, BHU in ghan form. The crude and prepared drug was standardized from Institute itself and the data of the patient was maintained by regular follow-ups. The cell line study of water extract of Khadir compound was also done to evaluate the proliferative or antiproliferative action by MTT assay. The clinical result have shown that this drug posses a very effective antipsoriatic action that has significantly reduced PASI score to nil and marked improvement in IGA scale, clinical symptoms andphotographic improvement was found. The cell line study by MTT assay has shown the antiproliferative action of Daruharidra (Berberis aristata) that was one of the constituent of Kitibha har kashay.Further study of this drug on psoriasis specific cytokines is needed to be evaluated by biochemical analysis to evaluate its role in breaking the pathology of psoriasis.
Formulation of Herbal Tea and in Vitro Evaluation of Antibacterial Activity Against Drug-Resistant Uropathogens
Authors: Akanksha Kesarwani , Tripathi Shraddha , Neha Mishra , Ranu Prasad , Neetu Mishra
Published: March 2023

The present study aims to formulate herbal tea and examine antioxidant and antimicrobial activity against uropathogens. Total phenolics content and radical scavenging activity of herbs (Hibiscus, Lemongrass, and Tinospora) and optimized tea were determined by the Folin–Ciocalteu method and percent of DPPH inhibition, respectively.The antibacterial activity of selected herbs and optimized tea were tested against three clinical isolates, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa using the modified agar disc diffusion method. The highest phenolic content and radical scavenging activity were observed in lemongrass, followed by hibiscus flower and tinospora stem. Although, the highest antibacterial activity was recorded by hibiscus flower against all tested pathogens, followed by lemongrass and tinospora. The sensory score of different treatments of herbal tea was analyzed by the Hedonic scale and treatment T2 (55:20:25) is found to be best followed by T1, T0, T3. The radical scavenging activity and antibacterial activity of herbal tea were found to be higher than in green tea. The herbal tea also exhibit significant antibacterial activity against common uropathogens E.coli (0.73mm),K.pneumoniae(0.5 mm) and P.aeruginosa (0.4 cm).  Therefore, the prepared herbal tea could be recommended for the prevention and treatment of urinary tract infection.
VatajaYonivyapada (gynecological condition): Scope in Ayurveda
Authors: Monisha VM  , Anuradha Roy
Published: March 2023

Introduction: Vatajayonivyapada having signs and symptoms such as pain along with abnormalities in menstrual bleeding matches with many of the gynaecologicaldisorders in women of reproductive age group. It hampers their day-to-day chores and disturbing their interpersonal relationship and most importantly compromises quality of life. Therefore, an instant relief of symptoms is required along with an overall improvement in the general condition of those women.In such conditions, a better alterative non-hormonal Ayurvedic management is planned. Ksheerapaka(medicated milk preparations) of Rasna, Gokshuraand Vasa having vedanahara (analgesic effect) is used in the study. Objective: In this research work our objective was to evaluate the therapeutic efficacy of oral RasnadiKsheerapaka in Vatajayonivyapada. Materials and method: Total 30 patients within 20-40 years of ageirrespective of the marital status having classical symptoms of Vatajayonivyapada have been selected randomly from Prasuti Tantra OPD, S.S. Hospital, BHU, Varanasi. After detailed history, complete examination and investigations patients selected for the study on the basis of selection criteria.Patientswere treatedwith Rasnadiksheerapaka50ml orally once in a day for total duration of 45 days. Study was assessed after completion of follow-up period. Result: Among the 28 cases, 5 patients became cured and 6 remained without any improvement and all the remaining 17 patients have got mild to marked improvement in the signs and symptoms. Conclusion: It is concluded that Rasnadiksheerapakahas got the therapeutic efficacy in the Vatajayonivyapadamanagement. Also helps in improving the overall health status and quality of life in such women.
Plant Extracts as Alternative Therapeutic Agents for Anaemia: A Review
Authors: Km Sukh Wati  , Mohd. Ehsan  , A K Singh  , M K Nandi
Published: March 2023

Anaemia, one of the most common blood nutrition deficiency affecting at all ages of people. In Ayurveda, according to Acharya Charak, sign and symptoms of anaemia has close resemblance to Pandu Roga as like paleness, weakness, Heart Tonic, Eye Inflammation etc. As WHO claims, Anaemia is a medical situation in which the amount of RBCs or Hb count is lower than the normal individual and it is estimated that over 40 percent of children below age five are anaemic.  On the basis of reported data plant extracts have been proved to be effective alternative therapy for the management of anaemic conditions. Physicians mostly prescribe iron-rich diet and vitamin supplements for the treatment of anaemia. Iron supplements are easily available in markets, if consumed prolonged, it can cause severe problems like gastro intestinal problems, hepatic disorders and sometimes even cause cancer. Hence, scientists are looking for an alternative for these iron supplements for the management of anaemia. Plant extracts could play a great role against anaemia. In this study, extracts of 20different plants as like- Solanum nigrum, Terminalia chebula, Beta Vulgaris etc. are discussed, which are experimentally proven to be effective in anaemia. Applications of these medicinal plants in anaemia is also mentioned in classical Ayurveda literature from ancient time. So, these plant extracts are may be an alternative therapy for the management of anaemia and this study could help researchers for research in anaemia and other related disorders.
A REVIEW ON NILINI: AN IMPORTANT AYURVEDIC MEDICINAL PLANTS
Authors: Dr. Ashwini Kumar Kushwaha
Published: March 2023

Nilini botanically identified as IndigoferatinctoriaLinn. belong to family Fabaceae. The plant is an important source of natural blue dye (Indigo) obtained from its leaflets and branches and traditionally used for the treatment of cough, splenomegaly, greying of hairs, backache, gout, abdominal distention, rheumatoid arthritis, fever and in worm infestation. Present chapter deals its historical, taxonomical, morphological, ethno-pharmacological and therapeutical aspects.
The Advancement of Nanotechnology in Treating Alzheimer’s Disease
Authors: Riya Singh  , Ayushi Maurya  , Neha Singh
Published: March 2023

Alzheimer’s disease is a neurodegenerative disorder with high prevalence in the rapidly increasingaging population in the worldwide. It is primarily caused by the collection of beta-amyloid plaques in the brain. The aim of this study to discuss the advancement of nanotechnology that help in the diagnosis and treatment of neurodegenerative disorder. Nanotechnology has shown its superiority that can applied medicinal uses and play great potential rolein therapy of Alzheimer’s disease. This is help to increasing the efficacy and efficiency of drug delivery by penetrating and overcoming the blood-brain barrier. There is need to explore and research in order to minimize the adverse effect and potential toxicity and to improve the drug bioavailability. The available medications in the market have only ability to slow down its progression.The current advances in the treatment of Alzheimer’s disease using nanotechnology contain the regeneration of stem cells, nanomedicine, and neuroprotection. The significantmediators for neuroprotection containnanogels, fullerene, dendrimers, gold nanoparticles and diamondoid derivatives
Phytochemical constituents and antioxidant activity of fresh and cooked Tamarillo - an indigenous fruit - using different drying methods
Authors: Suganya A  , Dr.C. A. Kalpana
Published: March 2023

Cyphomandra betacea is a shrub and flowering plant family of Solanaceae generating an egg shaped fruit. Tamarillo or tree tomato is the common name of the fruit. It is cultivated in Nilgiris districts of Tamilnadu and this fruit contains vitamins A,C,E and provitamin A and appreciable amounts of proteins, calcium, phosphorus, iron, zinc which helps to boost immunity. People consume the fruit as fresh, salad and juice forms. Chlorogenic acid content of the fruit helps to burn cholesterol and reduces the blood sugar level by functioning liver and pancreas. The fruit has sodium and potassium that helps to maintain blood pressure by regular intake. Anthocyanins and antioxidants of the fruit acts against free radicals and fights cancer. The aim of the study was to dry the fruits using different methods namely shade drying, cabinet drying, freeze drying and to identify the phytochemical constituents and analyse the antioxidant activity. The study shows that the fruit is attributed to an appreciable amount of bioactive components and good antioxidant activity. Tamarillo is a subtropical fruit, making fruits in dried form can preserve and secure out of season and available all over the year and the antioxidant activity of the fruit beneficial for human health.
Fish as bio-indicator tool for assessing estuarine health
Authors: K. Kadharsha  , Job Paul  , S. Ajmal Khan  , P.S. Lyla  , Bryan Raveen Nelson  , Akbar John
Published: March 2023

Fish Health Index and Index of Biotic Integrity directly indicates environmental health and was used in our monitoring at Coleroon, Vellar and Uppanar, estuaries in the southeast coast of India. The use of cast nets revealed 104 species of fish that belongs to 69 genera, 44 families and 10 orders. Assessment using fish health index at Coleroon, Vellar and Uppanar estuaries produced scores of 4.8692, 8.4981 and 1.4042 which means Vellar has better health than Coleroon and Uppanar. In addition, 12 metrics were used to produce the index of biotic integrity where total scores varied from 18 to 51. With Vellar achieving higher scores than Coleroon and Uppanar estuary, a Two-way ANOVA was employed to validate the data with significant achievement (P<0.005). Therefore, we can safely associate Coleroon, Vellar and Uppanar with ‘Fair’, ‘Good’ and ‘Very poor’ grades. Also, visual depiction of Vellar demarcates it as pristine in comparison to Coleroon and Uppanar that are subject to impairments along with dominance of omnivorous fishes. Knowledge from this study eases monitoring of important estuaries particularly for food security so that management sustains community livelihood.
Synergistic marmalade for sports person to improve muscle performance and ergogenic activity
Authors: A.Priya  , R. Rosalin Nikitha
Published: March 2023

The aim of this study is to provide natural ergogenic food products to the sports person. Marmalade is a food product made using fruit, peel and pulp. This acts as a convenient food for a sports person before a performance on the go. The ingredients Purple grapes, Watermelon and Beetroot juices were selected due to the following reasons. Purple grapes provide high run time (ergogenic effect) with the consumption of single dose. Watermelon juice relieves muscle soreness and fatigue. Beetroot juice increases the level of phosphocreatine resynthesis, increases muscle power in trained athletes and improves the release and reuptake of the calcium at the sarcoplasmic reticulum. The Synergistic marmalade was prepared in different variations and is compared with standard Grapes marmalade and the best one (Variation D) was selected using sensory analysis by 30 semi-trained panel members. The Nutrient analysis and Physiochemical analysis were carried out. The nutrients such as Potassium and Magnesium in Standard Grapes marmalade and Selected best sample were 210.3mg/100g and 10.16mg/100g and 213.6mg /100g and 12.32mg/100g respectively. Physiochemical analysis such as TSS was 65 % for standard as well as the selected variant, Titrable acidity was 0.67% for standard and 0.39% for selected variant and pH was 3.5 for standard and 3.27 for selected variant. All these parameters were tested to check the physical and chemical attributes of the Synergistic marmalade to be compared with the standard marmalade. The best variation was stored in two different packaging material – Glass jar and a Airtight plastic container in a refrigerator for a period of 21 days. During this period shelflife study was carried out using sensory evaluation and microbial analysis on 1st, 7th, 14th and 21st day. The results showed that the product is fit for consumption until 21 days and both the packaging were good for storage. The synergistic marmalade was popularized among adult sports persons by briefing on the significance, nutritional aspects, functional properties and other health benefits with the help of a pamphlet and questionnaire and analyzing the aftermath of the session.
Effect of a community-based nutrition intervention program about dietary immunonutrients during COVID-19 pandemic
Authors: Ravichandran Priyadharshini , V Subasshini
Published: March 2023

Background: The global agitation caused by the coronavirus disease of 2019 has emerged the need to make today’s population more aware of immune health to protect against disease and illness. Thus, we conducted a community-based nutrition intervention program that puts forward immunonutrition in the limelight.Objectives: To study the effects of a community-based nutrition intervention program on (a) the significance of immunonutrients, (b) its rich sources and (c) its role to boost immunity against viral infections and diseases among a local community in Chennai city.Material and Methods: This study used the pretest-posttest design consisting of pre-and post-survey conducted from 400 active participants selected by the random sampling method. Pretest and posttest involved the assessment tools like the 4-point Likert scale and 7-item food frequency questionnaire. The employed intervention strategies include the distribution of informative pamphlets and offering individual nutrition counselling that highlights the benefits of consuming immunonutrients- rich foods. Results: The mean pretest score based on the perception of participants on the importance of immunonutrients was 2.022±0.856. Significant associations between age, education level, and socioeconomic status with the perception levels of the participants were observed (P<0.001). A mean difference of 1.1200±0.0603 was observed when compared with the posttest responses conducted three months after the intervention, showing a significant increase in their perception level (P<0.001). Additionally, the consumption of immunonutrients rich foods studied using the 7-item food frequency questionnaire, also increased.Conclusions: Our intervention program was found remarkably effective for improving the awareness and consumption level of locally available, cost-effective immune-boosting foods among the participants and their intention toward healthy eating behaviour. Thus, a community-based nutrition intervention program would help upgrade awareness about the synergism of nutrition, immunity, and infection.