bluuebunny/crossref_metadata_2025 huggingface dataset:
Barriers and Drivers to Adoption of Water Reuse In Buildings: A Sociotechnical Analysis in Ceará, Brazil
Authors: Rodrigues Joab Antonio Martins , Cândido Luis Felipe , Lima Sérgio Henrique de Oliveira , Alexandre Alan Michell Barros
Published: November 2023

Purpose: This study aims to identify the barriers and drivers towards the adoption of water reuse systems in buildings in regions with water scarcity, such as the Brazilian Northeast.
 
Method: A qualitative study was carried out in the state of Ceará, Brazil. The study encompassed the analysis of content from seventeen in-depth interviews and documentary evidence.
 
Results and conclusion: The primary adoption drivers were found to be economic savings through consumption reduction and environmental awareness. Main barriers included the initial investment and payback time, as well as user practices, such as residents' lack of system maintenance. In addition, political and institutional aspects, such as the absence of fiscal incentives, also played a key role. In conclusion, water reuse in buildings constitutes an innovation that requires further development to promote significant adjustments of the socio-technical regime.
 
Originality/value: This research introduces innovation by conducting an analysis of the adoption of water reuse in buildings based on the multi-level perspective of socio-technical transitions towards sustainability. It focuses on a state in the Brazilian Northeast, whose territory is primarily situated in the Caatinga biome, characterized by a semi-arid climate and a history of severe drought cycles.
 
Research implications: The results provide valuable insights for researchers, technology developers, and policymakers to develop actions that stimulate the implementation and diffusion of water reuse in buildings.
STUDENTS' PERCEPTION OF THE USE OF GOOGLE FORMS IN ENGLISH SUBJECT
Authors: Ardhani Olyvia Vita , Pratista Ganang Yudha
Published: November 2023

Information Communication Technology (ICT) has become the centre of the teaching and learning process in the 21stcentury. The Covid-19 pandemic made teaching and learning shift to online and partially abandoned the conventional method. Google Forms is one of the applications commonly used by teachers to give students exercises and administer tests. Google Forms is a web-based data collection tool offered for free as part of the Google Suite application suite provided by Google Cloud. Hence, this study investigates the students' perception of using Google Forms in an English subject. This study was conducted through a qualitative descriptive method, and purposive sampling was employed to collect the data. The participants in this research were 15 students in grade 10 from one of the senior high schools in Magelang. This study gathered the data through a questionnaire and an interview. The closed-ended questionnaire data were analyzed by the frequency of students' responses and were stated in percentages. Then, the interview was taped, transcribed, and analyzed. The study concludes that Google Forms helps students do their homework more effectively and efficiently. The students believe that Google Forms is more practical in helping them do exercises than paper as they need to erase and type if they want to change the answer. Although most students claim that Google Forms is effective and efficient as a method of doing exercises, they also feel that there need to be more features that can motivate students to participate in the class. As a result, students' motivation does not improve using Google Forms.
Language and social minds: The semantics and pragmatics of intersubjectivity
Authors: Jin Yizhou , Xu Wei
Published: November 2023

This book provides a gradient model of intersubjectivity and social cognition in language. Through an interdisciplinary synthesis, the author proposes three levels of linguistic acts: those aimed at the speaker’s benefit alone, those expressing concern for an interlocutor, and those indicating concern for societal reactions. There is a continuum of egocentric to extended intersubjectivity, which includes co-actionality, immediate intersubjectivity, and collective constructions. The model is applied to study children’s mastery of intersubjective polysemy and verbal organization, and to determine “social mind” capabilities in autism spectrum disorders. While non-linguistic topics and further empirical validation are outside the scope, this innovative interdisciplinary approach meaningfully extends understanding of the intertwined nature of language, cognition, and social engagement.
Evaluation of Salivary Oxidative Stress Marker (Lipid Peroxidation), and Non-Enzymatic Antioxidants (Vitamin C and Vitamin E) in Patients with Acute Myocardial Infarction
Authors: R. Sarhat Entedhar , J. Mohammed Intesar , Y. Mohammed Noor , S. Khairy Bdoor , F. Hassan Ghosoon
Published: November 2023

Acute Myocardial Infarction (AMI), is the major cause of mortality and morbidity. There is substantial evidence that oxidative stress plays the major role in the atherosclerotic process. This study was aimed to evaluate the levels of salivary malondialdehyde (MDA), total antioxidant capacity (TAC) and non-enzymatic antioxidants (Vitamin C and Vitamin E) in AMI patients. Materials and methods: Sixty AMI patients (35 Males and 25 Females) with mean age of 54 ± 6.7 years and sixty control subjects with mean age 55 ± 6.2 years were incorporated in this study. Un stimulated saliva were collected from each subject in both groups. Malondialdehyde, and Total Antioxidant Capacity, Vitamin C and Vitamin E levels in saliva were estimated spectrophotometrically. SPSS computer software was used for data analysis. Results: Salivary MDA and TAC was significantly elevated in AMI patients compared with controls, while Vitamin C and Vitamin E were significantly decreased in AMI patients. Conclusions: Oxidative stress was increased in saliva of AMI patients, raised saliva MDA and TAC serve as marker of detecting chronic inflammation or be elevated as a consequence of oxidative stress in AMI patients. It may be taken in consideration that the saliva is so important tool in evaluation of lipid peroxidation and antioxidant agents to confirm the diagnosis of certain diseases
Implant Fixture Fracture (5-10 years clinical study)
Authors: H. Ali Nagham , H. Abdulla Emad
Published: November 2023

Introduction: Osseo integrated dental implant represents an advance management in modern dentistry, with high success rates. Despite that, several complications involve dental implants may still happen and dental surgeons should be attentive to such problem, to prevent implant failures and biomechanical problems. One of the most serious late implant complications is the fracture of implant fixture. It can be a challenge for dentists to determine the etiology of fixture fractures. Aim of study: Evaluate the effect of some implant parameters, such as length, diameter and position, on the occurrence of fixture fracture and to determine the incidence of fractures reported in 5-10 years of fallow up. Materials and methods: Clinical retrospective study included 439 implants made of titanium alloy(Ti-6Al-4V) placed in 192 Iraqi patients; 103 male patients and 89 female patients with partially and completely edentulous areas had consulted the implant department at Al- Elwiya specialized dental center in Iraq. Results: In this study 439 fixtures distributed in 192patients; 53, 6% was male patients; 46.3% female patients.3 fixtures fracture reported in this study represent 1.5% in relation to total number of patients. 0.6% of the 439 fixtures installed. 71 fixtures 16.1% supported prosthesis with Pontics; that reported 3 fixtures fracture 4.2%, while 368 fixtures 83.8% supported prosthesis without Pontics in which no fracture of fixtures were recorded. Discussion &Conclusion: Fracture of Osseo integrated dental implants is a late complication, it has low incidence, the fracture of dental implants fixture are multifactorial, and the most common cause for fracture is the biomechanical or physiologic overload.
Poor Management Odontogenic Infection Complications in Non-Medically Compromised Maxillofacial Patients in Salah Alden General Hospital
Authors: Ali Tuma Noori
Published: November 2023

Odontogenic infections one of the most common diseases in the oral and maxillofacial region. Precise &careful management of such patients very important. Poor management of odontogenic infection may leads to serious Complications in the maxillofacial region. Aims of the study. Hasten & facilitate patient recovery. Evaluate the most common poor management complication in maxillofacial region. Patients and methods. Sample of 20 patients complaining of poor management odontogenic infections. The data obtained from patients attending maxillofacial clinic. Same data collection formula for all patients. Results. The complications was, (10%) Buccal space abscess. (45%) Submandibular abscess. (10%) Submassetric abscess. (20%) Ludwig’s angina. (10%) Supra sternal abscess. (5%) Necrotizing fasciitis Pt no. complaining according to Poor type of treatment was (35%) Antibiotics only. (15%) Aspiration of abscess &Antibiotics. (35%) Inadequate abscess drainage &Antibiotics. (10%) Remove the cause only without fallow up. (5%) Extraction of non-causative tooth. Conclusion. Poor education, patient careless (neglected& poor oral hygiene), inadequate& poor management planning of cases May leads to these complications results.
Treatment of Distal Extension Edentulous Arches with Attachment Retained Cobalt Chromium Partial Dentures-A Case Report
Authors: Jameel Aljudy Hikmat
Published: November 2023

Background: The awareness and demand for quality of dental treatment is relatively increasing in recent generation and more so, as far as aesthetics are concerned, along with other functions of the prosthesis. In treating partially edentulous mouth, it requires more attention, principally for esthetics, in design. While achieving the goal, the components which are incorporated in removable partial denture may result in unsightly appearance. Case Description: A 77 year old patient reported to the replacement of his missing teeth for which a conventional maxillary complete denture and cast removable partial denture with precision attachments were planned to construct. Extra coronal resilient attachment was planned to re-claim support and thereby regain of lost esthetics in the mandibular arch. Conclusion: Use of precision attachment has amplified the aspects of retention and particularly, esthetics when compared to conventional removable partial dentures.
BERPIKIR KRITIS SISWA BERKEPRIBADIAN SENSING, INTUITION, THINKING DAN FEELING DALAM MENYELESAIKAN MASALAH DENGAN INFORMASI KONTRADIKSI
Authors: Kurniati Dian , Umami Anggi Nabilla , Murtikusuma Randi Pratama , Setiawan Toto Bara , Jatmiko Dhanar Dwi Hary
Published: November 2023

Critical thinking skill is necessary to be learned by every students, because by thinking critically students are able to understand other mathematical skills. One of the problems that can improve critical thinking skills is Problem With Contradiction Information (PWCI), which means problem that contains wrong information. Every student has their own characteristics, it also influences their critical thinking. One of the ways to identify a type of personality people is by using the Myers Briggs Type Indicator (MBTI), which classifies humans based on several perspectives, such as how to understanding and receiving information (Sennsing-Intuition), also how to make a conclusion and decision (Thinking-Feeling). The purpose of this study is to describe the critical thinking skills of students with sensing, intuition, thinking and feeling personalities. This research is a descriptive study with a qualitative approach. This research was based on SMAN Arjasa, and the subject was 8 students consisting of 2 students each with sensing, intuition, thinking and feeling personality. Data collection methods used are test and interview. The analysis technique used is the analysis of test results, interviews and triangulation.  The results of this research revealed that students with sensing, intuition, thinking and feeling personality types have their own characteristics when solving the problem. The results of the critical thinking test found that there were no students who were able to fulfill critical thinking skills but there were students who were able to find contradictory information in the question
ANALISIS PEMBELAJARAN MENGGUNAKAN PENDEKATAN SAINTIFIK DAN DISCOVERY LEARNING BERBANTUAN CANVA TERHADAP KEMAMPUAN PEMECAHAN MASALAH PADA MATERI TRANSFORMASI GEOMETRI KELAS IX
Authors: Hutajulu Masta , Agustiana Wina , Ningrum Nadia Putri Ayu , Yulianti Vivian , Sucahya Br Aritonang Paulani , Rahayu Dewi Sintia
Published: November 2023

Penelitian ini bertujuan untuk membandingkan hasil belajar siswa ketika menggunakan pendekatan saintifik dan model pembelajaran Discovery learning berbantuan canva, khususnya dalam materi transformasi geometri. Metode penelitian yang digunakan adalah metode deskriptif kuantitatif dengan memberikan soal tes mengenai materi transformasi geometri. Subjek PDA penelitian ini ialah siswa kelas IX D di SMP Negeri 3 Cimahi yang berjumlah 38 siswa. Data yang diperoleh selanjutnya diolah dengan menggunakan Microsoft Excel. Hasil penelitian menunjukkan bahwa rata-rata hasil belajar siswa yang mulanya 65 meningkat menjadi 76.
PENGEMBANGAN DESAIN PEMBELAJARAN MATEMATIKA DENGAN METODE FLIPPED CLASSROOM PADA MATERI TEOREMA PYTHAGORAS
Authors: Usman Muhammad Rizal , Mulbar Usman , Wahyuni Sri
Published: November 2023

Penelitian ini bertujuan untuk mengembangkan desain pembelajaran matematika dengan metode Flipped Classroom pada pokok bahasan teorema Pythagoras. Model pengembangan yang digunakan dalam pengembangan desain pembelajaran dengan metode flipped classroom adalah model ADDIE yang terdiri dari 5 tahap yaitu analysis, design, development, implementation, dan evaluation. Subjek penelitian ini adalah siswa kelas VIII F SMP Negeri 20 Bulukumba. Instrumen yang digunakan dalam penelitian ini adalah lembar validasi oleh para ahli, angket respon siswa, dan soal tes siswa materi teorema Pythagoras. Hasil penelitian pengembangan desain pembelajaran matematika ini melalui lima tahapan mulai tahapan analisis permasalahan dasar,analisis teori belajar dan materi, menyusun instrumen, angket dan soal, validasi instrumen oleh ahli, revisi instrumen, angket, pemilihan materi, pengembangan desain pembelajaran menggunakan metode flipped classroom, implementasi desain pembelajaran pada subjek sebanyak 25 siswa, hingga tahap evaluasi desain pembelajaran dengan melakukan penyebaran angket respon siswa dan tes hasil belajar. Hasil penelitian menunjukkan bahwa pengembangan desain pembelajaran matematika dengan metode flipped classroom yang dikembangkan layak digunakan karena memenuhi kriteria desain pembelajaran seperti valid dengan skor 3,64 dari para ahli. Memenuhi kriteria kepraktisan desain pembelajaran dengan persentase 84,48% untuk angket respon siswa dan memenuhi kriteria keefektifan desain pembelajaran dengan persentase 84% siswa yang memiliki nilai yang memenuhi KKM.
EFEKTIVITAS PENGGUNAAN MEDIA WORDWALL DAN MISTAR PINTAR TERHADAP HASIL BELAJAR OPERASI BILANGAN BULAT PADA SISWA KELAS RENDAH
Authors: Oktaviani Putri Shela , Casnan Casnan , Hadiana Oman , Heriyana Tio , Nurhayati Tati
Published: November 2023

Penelitian ini bertujuan untuk membandingkan keefektifan penggunaan media pembelajaran antara siswa yang mendapatkan penggunaan media pembelajaran wordwall dan media pembelajaran mistar pintar. Metode penelitian yang digunakan adalah Quasi eksperimen dengan desain Non-Ekuivalen. Populasi penelitian adalah siswa kelas rendah di Sanggar Bimbingan Sentul, Kuala Lumpur, Malaysia dengan pengambilan sampel menggunakan teknik purposive sampling. Instrumen penelitian yang digunakan berupa instrument tes. Hasil penelitian menunjukkan bahwa : (1) Terdapat perbedaan peningkatan hasil belajar siswa.(2) Terdapat Perbedaan Efektivitas penggunaan media pembelajaran, (3) Persentase rata-rata menunjukkan bahwa penggunaan media pembelajaran wordwall lebih efektif dibandingkan dengan media pembelajaran mistar pintar pada hasil pembelajaran siswa kelas rendah.
EFEKTIVITAS MEDIA PEMBELAJARAN BERBASIS DIGITAL “NUMERASI MATEMATIKA (NUMET)” MATERI BILANGAN BULAT TERHADAP KEMAMPUAN PEMAHAMAN MATEMATIS SISWA DI SB AMPANG MALAYSIA
Authors: Rismala Ade Irma , Hadiana Oman , Zaenal Reza Muhamad , Casnan Casnan , Heriyana Tio
Published: November 2023

Penelitian ini bertujuan untuk mengetahui perbedaan kemampuan pemahaman matematis siswa pada materi bilangan bulat antara kelas eksperimen yang menerapkan media pembelajaran berbasis digital Numerasi Matematika (NuMet) dengan kelas kontrol yang menerapkan pembelajaran konvensional. Penelitian ini merupakan jenis penelitian quasi eksperimen dengan desain penelitian Pretest-Posttest Control Group Design. Populasi pada penelitian ini adalah seluruh siswa SB Ampang dan mengambil sampel sebanyak dua kelas yaitu kelas V sebagai kelas eksperimen dan kelas VI sebagai kelas kontrol. Instrumen pada penelitian ini yaitu tes kemampuan pemahaman matematis berupa pretest dan posttest. Berdasarkan hasil penelitian, diketahui bahwa terdapat perbedaan pengaruh positif dan keefektivitasan penerapan media pembelajaran berbasis digital NuMet yang diterapkan pada kelas eksperimen dibandingkan dengan kelas kontrol dengan pembelajaran konvensional.
Representasi Bad Mother Dalam Film Pengabdi Setan
Authors: Pertiwi Narita
Published: November 2023

Penelitian ini dimulai dengan adanya animo film horror di kalangan masyarakat dan polemik generasi dengan masa transisi yang dihadapi. Melalui film Pengabdi Setan, film ini menyiratkan nilai konservatif mencakup dua hal tersebut. Penulis bertujuan memberikan prespektif baru dalam penelitian ini. Penelitian terdahulu hanya memberi pandangan ilmiah dari sisi ibu saja tanpa memberikan prespektif yang baru mengenai keterlibatan generasi dalam film tersebut. Dengan analisis wacana kritis dispositif bisa digunakan untuk menganalisis secara luas dalam lingkup karya film, penguat data dalam penelitian ini berupa wawancara dengan penulis yang membuat karya dengan pola cerita yang sama. Penulis menemukan peran nilai konservatif melalui figur Hantu Ibu memberi kesadaran akan rahim perempuan dibentuk menjadi Bad Mother dalam visual maupun tekstual serta hubungannya dengan transisi generasi muda.
Wajah Sang Calon Presiden: Prabowo Subianto Lewat Analisis Isi Instagram
Authors: Binsar Anton
Published: November 2023

- Indonesia will hold presidential elections in 2024. Several presidential candidates have begun to be voiced by political parties. One of them is Prabowo Subianto who currently serves as the Minister of Defense of the Republic of Indonesia. Prabowo Subianto himself has fought four times in a row in the presidential election, and 2024 is the fifth time in this political contest. Since the development of the internet, social media has become a channel for conveying messages. One that is growing rapidly and is used by public leaders is Instagram. Therefore it is important to see what public leaders, in this case Prabowo Subianto, want to convey to the public through the official Instagram account. The face or image of a public leader can be seen clearly through uploads made on Instagram. This research uses content analysis, and uses data from October 23, 2019 to December 1, 2022. This time span is since Prabowo Subianto was appointed as the Minister of Defense of the Republic of Indonesia. Through content analysis it was found that Prabowo communicated himself as a competent leader in his field. He also displays a fairly balanced professional side and personal life. Prabowo also described his close relationship with politicians and government agents as well as non-political public figures. It was found that the uploaded content lacked closeness with the community or the people. While the presidential election is very dependent on the people's vote at the time of the election. Instagram as a social media platform can be used to display images or messages for its audience.
Dinamika Kebijakan Keterwakilan Perempuan Pasca Reformasi Di Dewan Perwakilan Rakyat Republik Indonesia (DPR-RI)
Authors: Hidayat Endik , Susilo Daniel
Published: November 2023

The background of this research is the phenomenon of female minority groups in the Indonesian parliament DPR-RI. The formulation of the problem that arises is how is the representation of women in the post-reform parliament? This research uses political recruitment theory and party typology. This study uses a qualitative method of library research, especially previous studies. This study finds women's affirmation policies have been present in the post-referral election law. However, the implementation of the rules is still not effective in increasing the number of women representatives at the national level of the DPR-RI. Several inhibiting factors; First, the 30 percent quota regulation for women in political contestation is still a nomination. Second, the dominance of party elite decisions with a patriarchal mindset is often an obstacle that hinders women's political participation. Third, the pattern of party recruitment tends to be pragmatic in the nomination of cadres as candidates for legislative members.
Making The Disaster Trending
Authors: Elmada Maria Advenita Gita , Stephani Nicky , Ariestya Angga
Published: November 2023

Often referred to as a world disaster laboratory, Indonesia is one of the most prone to natural disasters globally. Disasters can happen at any time. Good disaster management is necessary given the colossal impact of disasters. Disaster communication is also vital in disaster management and is now closely related to social media. In a disaster situation, three types of information are commonly circulated on social media, namely situational information, sentiments, and personal opinions. This study attempts to map out the dominant information in the hashtag #KalselJugaIndonesia, which is related to the flood disaster in South Kalimantan last January 2021, which managed to become a trending topic overcoming other disaster discourses at the same time. This research is descriptive qualitative research with a directed qualitative content analysis method. As a result, it was found that sentiments of sympathy, sadness, and anger were the main drivers of the hashtag #KalselJugaIndonesia. In addition, the inclusion of this unusual and discourse-filled hashtag is the reason why people's attention can be drawn to the flood disaster in South Kalimantan at that time.
#1 Dermatologist Recommended: A Clinician’s Guide to Self-Tanning
Authors: Kay Kristen , Wilson Janice
Published: November 2023

Skin tanning is an evolving area of focus for dermatologists. For hundreds of years, fair skin was socially preferred. That is until Coco Chanel returned from the French Riviera in 1923 sporting a sun-tan. Since then, tanned skin has become a booming industry. As the perception of tanning evolved, so did the methods to attain it. Today, skin tanning is achieved by: outdoor UV tanning, indoor UV tanning, spray-tanning, or cosmetic self-tanning products. Dermatologists counsel against UV tanning, as UV exposure is correlated with increased risks of both melanoma and non-melanoma skin cancers. The question that remains to be investigated is the skin safety of self-tanning products. In this review, 20 products were chosen from five major U.S. retailers (Walmart, CVS, Sephora, Ulta, and Amazon). The product ingredients were then analyzed for skin safety. The resulting data suggests that there is no major difference in the number of ingredients that have been deemed safe by the major U.S. cosmetic regulatory bodies among the products, and that cosmetic products are likely getting safer every year. Therefore, clinicians should focus on application counseling and reiterate FDA guidelines by discouraging spray- tanning and tanning pills.
Suspected Role of Long-term Anticonvulsant Use in the Development of Squamous Cell Carcinoma
Authors: Shahzeidi Parastou , Downing Christopher , Cognetta Armand
Published: November 2023

Squamous cell carcinomas (SCC) are typically a tumor of advancing age (mean age at diagnosis: 70), with more than 80% of cases occurring among people aged 60 and older[1]. In addition, these cancers commonly appear on sun-exposed areas of the body such as face, ears, neck, non-hair bearing scalp, and dorsal aspect of extremities and hands[2]. Due to the rare presentation of the aforementioned case, involving a younger female patient with SCC on the hair-bearing scalp, secondary risk factors should be examined.   
Many commonly used anticonvulsants, including lamotrigine and valproic acid, have known photosensitizing properties[3]. In susceptible patients, the long-term interaction between photosensitizing medications and UV radiation elevates risk of damage from the sun and has the potential to increase the likelihood of developing skin cancer over time[4]. There have been minimal studies that examine a possible association between anticonvulsants and various skin cancers, though the topic remains controversial and without consensus. Among the known adverse effects lamotrigine are several cutaneous photosensitivity issues, including exaggerated sunburn, skin irritation, hypersensitivity and rash[5]. Valproic acid is often co-administered with lamotrigine for better management of epilepsy due to the synergistic effects. When given in combination, valproic acid has been found to significantly increase plasma levels and half-life oflamotrigine[6]. These increased lamotrigine levels and exposure could in turn increase the risk of photosensitivity reactions and additional sequelae, including skin cancers.
We report a 45-year-old woman who developed SCC on the scalp with a 10-year history of anticonvulsant use including lamotrigine and valproic acid.
Effect of Spesolimab on Achieving Sustained Disease Remission in Patients with Generalized Pustular Psoriasis: Results from the Effisayil 2 Study
Authors: Gordon Kenneth , Conrad Curdin , Lebwohl Mark , Barker Jonathan , Tsai Tsen-Fang , Merola Joseph , Conrad Curdin , Zheng Min , Hu Na , Hofmann Patrick , Thoma Christian , Eyerich Kilian
Published: November 2023

Introduction: Generalized pustular psoriasis (GPP) is a chronic, rare and potentially life-threatening disease characterized by flares of widespread skin pustulation. Sustained skin clearance is a key treatment objective. Intravenous (IV) spesolimab, an anti-interleukin-36 receptor monoclonal antibody, is approved for GPP flare treatment; however, the optimal dosing and long-term efficacy of subcutaneous (SC) spesolimab treatment in patients with GPP has not yet been reported. We report the effect of SC spesolimab on achieving sustained disease remission over 48 weeks in Effisayil 2 (NCT04399837), a trial that evaluated the efficacy and safety of SC spesolimab in preventing GPP flares.

 Methods: Patients with a history of GPP were randomized (1:1:1:1) to receive placebo (n=31), low- (n=31, 300 mg loading dose [LD]; 150 mg every 12 weeks [q12w]), medium- (n=31, 600 mg LD; 300 mg q12w) or high-dose (n=30, 600 mg LD; 300 mg every 4 weeks [q4w]) SC spesolimab over 48 weeks. Sustained remission was defined as GPP Physician Global Assessment (GPPGA) total score of 0 or 1 at all visits up to Week 48, or GPPGA total score of 0 or 1 and all GPPGA subscores ≤2 at all visits up to Week 48. Sustained pustular clearance was defined as GPPGA pustulation subscore of 0 at all visits from Week 4 to Week 48. Any use of IV spesolimab or another standard of care for GPP worsening was considered a failure of remission. Missing data were imputed by a sequential logistic regression multiple imputation method. Adjusted risk differences (RD) were calculated by the Mantel−Haenszel type-weighted average of differences.

 Results: 31 patients received placebo, and 30 patients received high-dose spesolimab. Compared to placebo, more patients had sustained remission in the high-dose arm using both GPPGA total score 0 or 1 (63.3% vs 29.0%; RD [95% CI] 0.35 [0.10–0.59]), and GPPGA total score 0 or 1 and all GPPGA subscores ≤2 (60.4% vs 29.0%; RD [95% CI] 0.32 [0.07–0.56]). Compared to placebo, more patients in the high-dose arm had sustained pustular clearance over 48 weeks (63.6% vs 25.8%; RD [95% CI] 0.38 [0.14–0.62]).

Conclusion: Overall, high-dose SC spesolimab q4w is effective for the long-term management of GPP skin symptoms.
Comparative Bioavailability of DFD-29 (Minocycline Hydrochloride Modified Release Capsules, 40 mg) Vs. Minocycline Hydrochloride Extended Release 105-mg tablets After a Single Oral Dose: A Randomized, 3-way Crossover Study
Authors: Sidgiddi Srinivas , Gautam Aniruddh
Published: November 2023

Background: A low-dose formulation (DFD-29) of minocycline hydrochloride (HCl) is under evaluation for the treatment of moderate-to-severe papulopustular rosacea. The objective of this phase 1 study is to compare the bioavailability of DFD-29 to that of the currently available Solodyn® (minocycline HCl extended release) 105-mg formulation.
Methods: This single-center, randomized, open-label, laboratory-blinded, 3-way, 6-sequence crossover study compared the pharmacokinetics of a single dose of DFD-29 40 mg after an overnight fast, DFD-29 40 mg after a high-fat meal, and minocycline HCl extended release 105-mg tablet (minocycline HCl ER 105 mg) after an overnight fast in healthy adult volunteers. Blood samples were collected for PK assessments prior to and up to 72 hours after each drug dose, with a washout period of 7 calendar days between doses. Safety was evaluated by monitoring adverse events (AEs), vital signs, and laboratory tests.
Results: A total of 24 subjects were randomized and 23 subjects completed the study. Mean plasma minocycline Cmax levels were 243.9 ng/mL for DFD-29 (fasting), 225.0 ng/mL for DFD-29 (fed), and 497.3 ng/mL for minocycline HCl ER 105 mg (fasting). The geometric least squares (LS) mean ratios for Cmax, AUC0-T, and AUC0-∞ of DFD-29 to minocycline HCl ER 105 mg when administered after fasting were 47.97%, 36.55%, and 38.35%, respectively. When comparing fasting vs fed administration of DFD-29, geometric LS mean ratios for Cmax, AUC0-T, and AUC0-∞ were 97.48%, 116.84%, and 115.26% respectively. Tmax was 1.5 h for DFD-29 (fasting), 4.5 h for DFD-29 (fed), and 4.0 h for minocycline HCl ER 105 mg (fasting). Treatment-emergent AEs (TEAEs) were reported in 17.4%, 13.0%, and 21.7% after administration of DFD-29 (fasting), DFD-29 (fed), and minocycline HCl ER 105 mg, respectively. Most TEAEs were mild in severity (21/22; 95.5%).
Conclusion: Bioavailability was significantly lower after a single dose of DFD-29 40 mg vs minocycline HCl ER 105 mg following a single dose under fasting and fed conditions. Food intake had no impact on Cmax but may delay absorption and may slightly increase exposure. Overall, single oral doses of DFD-29 40 mg and minocycline HCl ER 105 mg were generally safe and well tolerated.
This study and abstract are funded by Journey Medical Corporation.
Analytical assessment of fire tank and fire reservoir operating range
Authors:   State Fire Academy of EMERCOM of Russia, Zhuchkov Vitaly V. , Peterburgsky Dmitry A. ,   State Fire Academy of EMERCOM of Russia, Boldyrev Evgeny N. ,   State Fire Academy of EMERCOM of Russia
Published: November 2023

PURPOSE. Draft amendments and addendums to code 8.13130.2020 “Fire protection systems. Outdoor fire-fighting water supply. Fire safety requirements”, according to which it is proposed to increase working radius of fire tanks and fire reservoirs to 400 m are analyzed. Regulatory documents regarding outdoor fire-fighting water supply for the period from 1947 to the present are examined. The authors analyzed aspects related to determining operating range of a fire tank and an artificial fire reservoir, depending on the capabilities of fire departments and fire-fighting equipment. Such aspects include level of equipping main fire trucks and technical capabilities of pumping equipment for using water sources located at a distance of up to 400 m from the fire site, as well as the number of combat crews arriving at the fire scene. METHODS. System and structural analysis, mathematical statistics, descriptive analysis were used. FINDINGS. The authors proposed and analyzed possible schemes for using water sources located at a distance of more than 200 m from protected objects; analytical characteristics of pump-hose systems for the proposed schemes were obtained; the operating characteristics of a fire pump and pump-hose systems were constructed in the same coordinate systems. RESEARCH APPLICATION FIELD. The results can be used when making a final decision to increase the operating range of fire tanks and fire reservoirs. CONCLUSIONS. With working radius of buildings and structures with fire tanks and artificial reservoirs, the value of which will exceed 200 m, the time of emergency rescue services deployment and free fire development will increase; operational capabilities of fire department to solve related tasks will be reduced; water supply for firefighting will be provided by at least two medium or heavy class fire trucks; organizing water supply into pumping with sequential operation of fire truck pumps will be required.
The order of involving fire and rescue units in fires of higher ranks
Authors:   State Fire Academy of EMERCOM of Russia, Uvaliev Didarkhan S.
Published: November 2023

PURPOSE. The order and priority of involving fire and rescue units in fires that have already been burning and in potential ones of higher ranks according to the units departure schedule of territorial fire and rescue garrison to extinguish fires and perform emergency rescue operations using as the example Moscow city are considered. METHODS. A comparative analysis of involving fire and rescue units in fires of higher ranks using geographic information systems has been carried out. The research results have been summarized and extrapolated to potential fires. FINDINGS. The results of comparing fire and rescue units involvement in fighting higher ranks potential fires and fires that have already occurred demonstrate different priority options of units dispatch. Priority options for fire and rescue units involvement are determined by the location of burning facility and possible routes to the fire scene. These conditions cannot be taken into account in the departure schedule. The study has made it possible to determine that the sequential order of fire and rescue units involvement has an impact on the total concentration time of units for certain fire ranks. An algorithm has been developed that, by geographic information systems, alternately determines the involvement of the nearest fire and rescue units to potential fires of higher ranks. RESEARCH APPLICATION FIELD. The article is of a theoretical nature and is aimed at improving the functioning of fire and rescue garrisons. In the future, the findings of the research will make it possible to improve the existing automated management systems for fire and rescue garrisons, as well as simulation systems of their functioning. CONCLUSIONS. The presented algorithm will enable the rapid concentration of fire and rescue units at a higher rank fire scene, as well as reduce possible casualties and property damage. At the same time, the algorithm will allow the management and dispatch staff of fire and rescue garrisons to minimize time necessary for making managerial decisions, ensure control over fuels and lubricants consumption and reduce the depreciation of fire appliances.
Analysis of fires in the USA
Authors:   State Fire Academy of EMERCOM of Russia, Brushlinsky Nikolay N. , Sokolov Sergey V. ,   State Fire Academy of EMERCOM of Russia, Grigorieva Margarita P. ,   State Fire Academy of EMERCOM of Russia
Published: November 2023

PURPOSE. The article provides statistical study results of the situation with fires and their consequences, the “cost” of fires in 1959–2014 in the USA. The main objectives of the study are: analysis of statistical indicators characterizing the number of fires and their consequences for the period from 1980 to 2020, as well as cost assessment for fire protection reduced to a quantitative indicator of “losses” from fires. METHODS. Methods of mathematical statistics, system analysis. FINDINGS. The article summarizes the results of the statistical analysis of fires in the USA for the period from 1980 to 2020. The integral fire risks comparative analysis for the USA, India, Great Britain, Germany, Russia and the USSR for the period from 1959 to 2020 was carried out. The “cost” of fires was estimated as cost relative indicator for ensuring fire safety and losses from fires. RESEARCH APPLICATION FIELD. The results of the study can be applied by specialists of fire services of world countries for comparative analysis of fire hazard level of countries and cities. CONCLUSIONS. For the period of 2018–2020 in the USA for every 1,000 people there were 4.8 fires, while for every 100 fires – 0.2 casualties that indicates a satisfactory situation with fires relative to other countries (for example, India). When estimating fire safety costs, it was found out that the “cost” of fires in the USA for the period from 1980 to 2014 had increased from $220 billion to $328.5 billion (including inflation) but the “cost” of fires in shares of GDP had decreased from 7.6% to 1.9% (due to the growth of US economic indicators). It can be stated that the increase in costs for firefighting since 1980 has contributed to keeping a successful trend towards a decrease in number of fires and fire casualties taking into account constantly increasing population rate.
Ekonomik Yaptırımlar ve Uluslararası Ticaretin Silahlaştırılması: Küresel Aktörlerden Örnekler
Authors: ÇEVİK Veli Ahmet
Published: November 2023

Küreselleşme ile birlikte bağlantılılık düzeyi artan toplumlar, uluslararası ticarette birbirine daha bağımlı hale gelmişlerdir. Bu bağımlılık düzeyi dünya barışına katkı sağlarken aynı zamanda uluslararası ticareti kırılgan hale getirmiştir. Günümüzde ülkelerin uluslararası ticarette birbirine asimetrik olarak bağımlı olması, ticaretin dış politikada bir araç olarak kullanılmasına da yol açmıştır. Bu araçlardan biri olan yaptırımların tarihi eski Yunan medeniyetlerine kadar uzansa da son yıllarda dünya kamuoyunun gündeminde çok daha sık şekilde yer almaya başlamıştır. Geleneksel yaptırımlardan ve ticaret savaşlarından farklı olarak, ülkelerin hedef ülkeye karşı avantajlı olduğu ticareti silahlaştırarak hem ticari hem de siyasi ilişkilerinde araç olarak kullanması günümüz uluslararası ticaretinin en önemli konularından biri haline gelmiştir. Ticarete konu herhangi bir alanda üstün olan devlet diğer devletlerin kararlarını etkilemek amacıyla ekonomik zorlamaya başvurabilmektedir. Bu çalışmada öncelikle yaptırımların ekonomik ve finansal alanlarda yoğunlaşarak, daha fazla dış politika aracı olarak kullanılması incelenmiştir. Yaptırımlardan istenilen sonuç alınmış olsa da, ilerleyen süreçte hedef aktörler yaptırımlara karşı duyarsız hale gelebilecektir. Ayrıca yaptırımlar her zaman başarıyla sonuçlanmayacaktır. Başarısız olan yaptırımlar istenmeyen durumun daha da şiddetlenmesine yol açabilecektir. İkinci olarak ise karşılıklı ekonomik bağımlılıkların güçlü ticarete sahip ülkeler tarafından ekonomik zorlama yoluyla politika amaçlarına kaldıraç olarak kullanılması incelenmiştir. Karşılıklı bağımlılık küresel ticaretin artmasına ve endüstrilerin uzmanlaşmasına yol açmıştır. Ancak riskleri de beraberinde getirmiştir. Yaptırımlar ve ekonomik zorlamalar, hedef ülkeleri bu riskleri azaltmaya yönlendirmekte ve bu eğilim serbest ticarete zarar vererek ülkeleri korumacılık politikalarına sevk etmektedir.
Diabetic Patients and Peritoneal Dialysis
Authors: Allata Yassine , Chouhani Basmat Amal , EL Bardi Ghita , Sqalli Houssaini Tarik , Kabbali Nadia
Published: November 2023

The prevalence of diabetes mellitus (DM) among patients requiring renal replacement therapy (RRT) has been on the rise worldwide, with DM now being the primary cause of end-stage renal disease (ESRD) in roughly one-third of RRT initiations. Although renal transplantation is the optimal treatment for ESRD, its limited availability has led to in-center hemodialysis (HD) being widely used as the default RRT modality in many countries. However, peritoneal dialysis (PD) may offer a superior option for diabetic patients due to its slower ultrafiltration rate, which can help mitigate the dialysis-induced hypotension and coronary ischemia that are associated with extracorporeal circulation during HD. Despite these advantages, unfounded concerns about technique failure and increased complication rates have discouraged some clinicians from recommending PD as a first-line RRT for diabetic patients. We conducted a retrospective study comparing the incidence of complications and technique survival rates between diabetic and non-diabetic patients undergoing PD at a dialysis unit in Morocco. Our findings reveal that, diabetic patients undergoing PD experienced no significant difference in technique survival or incidence of complications compared to their non-diabetics. Nevertheless, only a small proportion (17.5%) of patients in our PD unit was diabetic, suggesting a need to improve access to PD for diabetic patients with ESRD.
Analyzing the Epic of Mem and Zin According to Vladimir Propp’s Narratology
Authors: Saleh Chaware , Ahmed Saya
Published: November 2023

This study is an attempt to analyze the plot of Ehmedê Xanî(1650-1707)’s Mem and Zin based on Vladimir Propp’s (1895-1970) Narrative Theory who is a Soviet folklorist. The effort is to find out how many functions have  appeared in the epic and to point out seven broad character types that are mentioned by Propp in his most famous book the Morphology of the Folktale (1928).  There are several theories that analyze some basic elements of stories, such as Joseph John Campbell’s “The Hero’s Journey” and Maureen Murdock’s “The Heroine’s Journey”. But among all, this paper has chosen a narratology structuralism study which has been explained by Propp. His theory is one of the well-spread theories and views all literature genres in the form of certain fixed structures.
Cristae dynamics is modulated in bioenergetically compromised mitochondria
Authors: Golombek Mathias , Tsigaras Thanos , Schaumkessel Yulia , Hänsch Sebastian , Weidtkamp-Peters Stefanie , Anand Ruchika , Reichert Andreas S , Kondadi Arun Kumar
Published: November 2023

Cristae membranes have been recently shown to undergo intramitochondrial merging and splitting events. Yet, the metabolic and bioenergetic factors regulating them are unclear. Here, we investigated whether and how cristae morphology and dynamics are dependent on oxidative phosphorylation (OXPHOS) complexes, the mitochondrial membrane potential (ΔΨm), and the ADP/ATP nucleotide translocator. Advanced live-cell STED nanoscopy combined with in-depth quantification were employed to analyse cristae morphology and dynamics after treatment of mammalian cells with rotenone, antimycin A, oligomycin A, and CCCP. This led to formation of enlarged mitochondria along with reduced cristae density but did not impair cristae dynamics. CCCP treatment leading to ΔΨmabrogation even enhanced cristae dynamics showing its ΔΨm-independent nature. Inhibition of OXPHOS complexes was accompanied by reduced ATP levels but did not affect cristae dynamics. However, inhibition of ADP/ATP exchange led to aberrant cristae morphology and impaired cristae dynamics in a mitochondrial subset. In sum, we provide quantitative data of cristae membrane remodelling under different conditions supporting an important interplay between OXPHOS, metabolite exchange, and cristae membrane dynamics.
Early Neolithic Complexes of the Buguldeika 1 Geoarchaeological Site (Western Coast of Lake Baikal)
Authors:   Irkutsk State University, Novikov A. G. , Goriunova O. I. ,   Irkutsk State University, Klementiev A. M. ,   Institute of the Earth's Crust SB RAS, Weber A. W. ,   University of Alberta,   Irkutsk State University
Published: November 2023

For the first time, the materials of the Early Neolithic complexes (cultural layers 7 and 8) of the multilayered site Buguldeika 1 on western coast of Lake Baikal, excavated in 2016 by A. A. Timoschenko and E. N. Bocharova, are introduced in full. A comparative analysis of materials from layers 7 and 8 showed that these complexes are largely homogeneous in nature (in terms of production and typology of ceramics and stone items). The differences lie in the changed proportions of cord-impressed Khaita and net-impressed ceramics (the predominance of the first of them in layer 8, and the second in layer 8). The complex of layer 7 contains a more diverse set of stone products, including rods of compound fishhooks of not only the Baikal, but also the Kitoi-like type. Some features were recorded in the composition and ratio of fauna remains, which made it possible to outline differences in fishing strategies: 1) layer 8 – hunting of ungulates, 2) layer 7 – specialized hunting for seals. Probably, such difference is explained by the seasonal characteristics. Based on the stratigraphy, comparison of archaeological materials with synchronous complexes of main multilayered sites of the Cis-Baikal and radiocarbon AMS dating, the age of the cultural layers of the studied site was determined. They represent different chronological periods of the Early Neolithic: layer 8 – 7779–7576 cal BP, and layer 7 – 7406–7168 cal BP. An important point of this study is the fact of the presence of bighorn sheep on the coast of Lake Baikal during the boreal stage of the Holocene (8981–8398 cal BP). Excavations at the Buguldeika 1 showed the prospects for further research of this site and confirmed the existence in the Early Neolithic of the Cis-Baikal of different traditions for the production of ceramic vessels: with impressions of woven net and impressions of cord (Khaita type). A series of radiocarbon dates obtained from all complexes of Cis-Baikal Early Neolithic sites (including Buguldeika 1) indicate that both pottery traditions existed relatively synchronously in the chronological range of 8160–7000 cal BP. A comparative analysis of the Early Neolithic complexes of the Baikal coast with materials from multilayered sites in the south of Middle Siberia showed their correspondence with each other in several techno-morphological characteristics and, above all, in the manufacture of ceramics.