bluuebunny/crossref_metadata_2025 huggingface dataset:
“What Do We Know about Hope in Nursing Care?”: A Synthesis of Concept Analysis Studies
Authors: Antunes Mónica , Laranjeira Carlos , Querido Ana , Charepe Zaida
Published: October 2023

Hope is a central concept within the nursing literature, which is crucial towards the development of nursing knowledge. Nursing teams play a crucial role in exploring the meaning of hope and promoting hope among patients and their families. This study aims to synthesize concept analysis studies of hope in the context of nursing care and to propose an evidence-based update of the definition of hope in the International Classification for Nursing Practice (ICNP®). Method: This is a literature review, involving the synthesis of studies concerning the concept analysis of hope in nursing practice. Peer-reviewed articles with fully accessible Portuguese or English text were considered. As we aimed to include a historical perspective of the concept, no restriction upon the time of publication was set. Articles were selected in March 2022 and updated in July 2023 using the Medline, CINAHL, and Scopus databases. The search terms used were “hope” AND “concept” AND “analysis” AND “nurs*”. Only articles written in English or Portuguese were included. Two reviewers conducted the research synthesis and report independently to minimize the risk of bias in the included studies. This paper adheres to the PRISMA checklist. To clarify the concept of hope as perceived by patients and develop hope as an evidence-based nursing concept, 13 studies were reviewed. The concept of hope, its attributes, antecedents, and consequences, as well as similar concepts, were studied by nurses and synthesized into a definition. The identified antecedents include pivotal life events, stressful stimuli, and experiencing satisfaction with life. The analysis of its attributes, antecedents, and consequences has contributed to understanding its relevance in nursing care and provided a proposed update of hope in the ICNP®. This review provides conceptual clarity on how hope is defined and used in nursing practice and the potential factors that may impact the promotion of hope to provide opportunities for future nursing research.
Automating Seedling Counts in Horticulture Using Computer Vision and AI
Authors: Fuentes-Peñailillo Fernando , Carrasco Silva Gilda , Pérez Guzmán Ricardo , Burgos Ignacio , Ewertz Felipe
Published: October 2023

The accelerated growth of computer vision techniques (CVT) has allowed their application in various disciplines, including horticulture, facilitating the work of producers, reducing costs, and improving quality of life. These techniques have made it possible to contribute to the automation of agro-industrial processes, avoiding excessive visual fatigue when undertaking repetitive tasks, such as monitoring and selecting seedlings grown in trays. In this study, an object detection model and a mobile application were developed that allowed seedlings to be counted from images and the calculation of the number of seedlings per tray. This system was developed under a CRISP-DM methodology to improve the capture of information, data processing, and the training of object detection models using data from six crops and four types of trays. Subsequently, an experimental test was carried out to verify the integration of both parts as a unified system, reaching an efficiency between 57% and 96% in the counting process.
Is Positive Affect as a Trait Related to Higher Heart Rate Variability in a Stressful Situation?
Authors: Sveinsdóttir Sigrún Þóra , Jóhannsdóttir Kamilla Rún
Published: October 2023

Most of the studies on the effect of trait positive affect (PA) and cardiovascular activity have focused on heart rate (HR) and blood pressure (BP) rather than heart rate variability (HRV). However, trait PA might sustain homeostasis for the autonomic system (ANS) by reducing activity in the sympathetic system (SNS) and increasing the activity in the parasympathetic system (PNS). A common index for the PNS is the vagal tone measured indirectly through HRV. The present study assessed whether trait PA influences cardiovascular response to various stress tasks by monitoring participants’ HRV measured by RMSSD (root mean square of successive differences) along with HR and interbeat interval (IBI). A total of 54 participants performed various cognitive tasks and Trier Social Stress Tasks while their vital signs were monitored, and trait PA was measured with PANAS. The cognitive tasks included both high- and low-stress tasks, including fatigue-inducing 20 min Stroop tasks. The results showed overall higher HRV as measured by RMSSD for participants who have higher levels of trait PA, indicating more PNS activity compared with low-trait-PA individuals, particularly at the end of the task performance during the fatigue induction. High-trait-PA individuals also had a lower HR during the fatigue-inducing task and a higher IBI. The results support previous work by further indicating a more adaptive response and consequently better emotional regulation for high-trait-PA individuals in a complex, prolonged task setting.
“Caregiving Youth” and the Patchwork History of Recognition in the United States
Authors: Olson Elizabeth , Edmonds Leiha
Published: October 2023

This article examines the U.S. legislative and policy landscape and its historical and contemporary recognition of young people as caregivers and their importance to public health, both as care providers and as a category of special concern for overall wellbeing. Drawing on feminist geographies of health to situate a historical analysis, we aim to answer two key questions: First, what is the history of recognition of caregiving youth in key moments of federal action to address family caregiving needs? Second, how might we use this history to better understand and analyze the patchwork geography of caregiving youth recognition in the U.S. and other countries that similarly lack formal national policy recognition to improve and enhance public health? We use the term patchwork to describe how federal recognition of caregiving youth in broader debates about public health is uneven across both time and space, and contingent upon civil society, non-profit organizations, and researchers working in and with geographically bound communities. Our results illustrate how a focus on the relationships of recognition, both in the past and the present and at local and national scales, reveals a different perspective on caregiving youth in the U.S. with a much more complex history than previously identified. The article describes how relationships established in the absence of federal policy or legislation are sometimes directed towards building more formal recognition, and other times with the goal of changing practices in a specific location.
Trace and Major Element Concentrations in Cadaveric Lung Tissues from World Trade Center Health Registry Decedents and Community Controls
Authors: Marmor Michael , Burcham Joyce L. , Chen Lung-Chi , Chillrud Steven N. , Graham Jason K. , Jordan Hannah T. , Zhong Mianhua , Halzack Elizabeth , Cone James E. , Shao Yongzhao
Published: October 2023

Studies of the health impacts of the 11 September 2001 terrorist attacks on New York City’s (NYC’s) World Trade Center (WTC) towers have been hindered by imprecise estimates of exposure. We sought to identify potential biomarkers of WTC exposure by measuring trace and major metal concentrations in lung tissues from WTC-exposed individuals and less exposed community controls. We also investigated associations of lung tissue metal concentrations with self-reported exposure and respiratory symptoms. The primary analyses contrasted post-mortem lung tissue concentrations obtained from autopsies in 2007–2011 of 76 WTC Health Registry (WTCHR) enrollees with those of 55 community controls. Community controls were frequency-matched to WTCHR decedents by age at death, calendar quarter of death, gender, race, ethnicity and education and resided at death in NYC zip codes less impacted by WTC dust and fumes. We found WTCHR decedents to have significantly higher iron (Fe) lung tissue concentrations than community controls. Secondary analyses among WTCHR decedents adjusted for sex and age showed the log(molybdenum (Mo)) concentration to be significantly associated with non-rescue/recovery exposure. Post hoc analyses suggested that individuals whose death certificates listed usual occupation or industry as the Sanitation or Police Departments had elevated lung tissue Fe concentrations. Among WTCHR decedents, exposure to the WTC dust cloud was significantly associated with elevated lung tissue concentrations of titanium (Ti), chromium (Cr) and cadmium (Cd) in non-parametric univariable analyses but not in multivariable analyses adjusted for age and smoking status. Logistic regression adjusted for age and smoking status among WTCHR decedents showed one or more respiratory symptoms to be positively associated with log (arsenic (As)), log(manganese (Mn)) and log(cobalt (Co)) concentrations, while new-onset wheezing and sinus problems were negatively associated with log(Fe) concentration. Fe concentrations among individuals with wheezing, nonetheless, exceeded those in community controls. In conclusion, these data suggest that further research may be warranted to explore the utility as biomarkers of WTC exposure of Fe in particular and, to a lesser extent, Mo, Ti, Cr and Cd in digestions of lung tissue.
Deep-Learning-Based Annotation Extraction Method for Chinese Scanned Maps
Authors: Rao Xun , Wang Jiasheng , Ran Wenjing , Sun Mengzhu , Zhao Zhe
Published: October 2023

One of a map’s fundamental elements is its annotations, and extracting these annotations is an important step in enabling machine intelligence to understand scanned map data. Due to the complexity of the characters and lines, extracting annotations from scanned Chinese maps is difficult, and there is currently little research in this area. A deep-learning-based framework for extracting annotations from scanned Chinese maps is presented in the paper. Improved the EAST annotation detection model and CRNN annotation recognition model based on transfer learning make up the two primary parts of this framework. Several sets of the comparative tests for annotation detection and recognition were created in order to assess the efficacy of this method for extracting annotations from scanned Chinese maps. The experimental findings show the following: (i) The suggested annotation detection approach in this study revealed precision, recall, and h-mean values of 0.8990, 0.8389, and 0.8635, respectively. These measures demonstrate improvements over the currently popular models of −0.0354 to 0.0907, 0.0131 to 0.2735, and 0.0467 to 0.1919, respectively. (ii) The proposed annotation recognition method in this study revealed precision, recall, and h-mean values of 0.9320, 0.8956, and 0.9134, respectively. These measurements demonstrate improvements over the currently popular models of 0.0294 to 0.1049, 0.0498 to 0.1975, and 0.0402 to 0.1582, respectively.
The Seasonal Migrants Spatially Affect the Park Green Space Accessibility and Equity under Different Travel Modes: Evidence from Sanya, China
Authors: Yang Wentong , Cheng Yeqing , Xu Chunru , Zhang Jinping
Published: October 2023

The influx of seasonal migrants has a significant impact on public services in destination places and may reshape the spatial accessibility and equity patterns of park green space (PGS). However, the two-step floating catchment area (2SFCA) method and its extended forms neglect discrepancies between the travel behaviors of seasonal migrants and native residents and thus fail to delineate variations in PGS accessibility and equity in areas with seasonal migrants. To avoid this issue, this study drew on the case of Sanya, a city with large numbers of Houniao, who are primarily retirees leading seasonal migration between the north and the south of China. A multi-group, multi-mode Gaussian-based 2SFCA method was also proposed to evaluate the PGS accessibility and equity before and after the Houniao influx. The method considered the changes in the COVID-19 restrictions from a refined perspective, with fine-scale residential areas being the research units and travel time requested from the web map application programming interface. The results showed that most residential areas were found to have relatively low PGS accessibility and equity levels, except for those in the south-central and southwestern urban areas of Sanya. Both the Houniao influx and lifted COVID-19 restrictions affected the spatial patterns of PGS accessibility and equity. PGS accessibility and equity were decreased by the Houniao influx, whereas walking and public transport within a few residential areas outside Houniao gathering spots improved. This study can serve as a basis for the reasonable planning of PGS and other public services in cities receiving seasonal migrants, such as Sanya.
Genome-Wide Identification and Analysis of the Genes Encoding Q-Type C2H2 Zinc Finger Proteins in Grapevine
Authors: Chu Mingyu , Wang Tiaoye , Li Wenfang , Liu Yashi , Bian Zhiyuan , Mao Juan , Chen Baihong
Published: October 2023

Q-type C2H2 zinc finger proteins (ZFPs), the largest family of transcription factors, have been extensively studied in plant genomes. However, the genes encoding this transcription factor family have not been explored in grapevine genomes. Therefore, in this study, we conducted a genome-wide identification of ZFP genes in three species of grapevine, namely Vitis vinifera, Vitis riparia, and Vitis amurensis, based on the sequence databases and phylogenetic and their conserved domains. We identified 52, 54, and 55 members of Q-type C2H2 ZFPs in V. vinifera, V. riparia, and V. amurensis, respectively. The physical and chemical properties of VvZFPs, VrZFPs, and VaZFPs were examined. The results showed that these proteins exhibited differences in the physical and chemical properties and that they all were hydrophobic proteins; the instability index showed that the four proteins were stable. The subcellular location of the ZFPs in the grapevine was predicted mainly in the nucleus. The phylogenetic tree analysis of the amino acid sequences of VvZFP, VaZFP, VrZFP, and AtZFP proteins showed that they were closely related and were divided into six subgroups. Chromosome mapping analysis showed that VvZFPs, VrZFPs, and VaZFPs were unevenly distributed on different chromosomes. The clustered gene analysis showed that the motif distribution was similar and the sequence of genes was highly conserved. Exon and intron structure analysis showed that 118 genes of ZFPs were intron deletion types, and the remaining genes had variable numbers of introns, ranging from 2 to 15. Cis-element analysis showed that the promoter of VvZFPs contained multiple cis-elements related to plant hormone response, stress resistance, and growth, among which the stress resistance elements were the predominant elements. Finally, the expression of VvZFP genes was determined using real-time quantitative PCR, which confirmed that the identified genes were involved in response to methyl jasmonate (MeJA), abscisic acid (ABA), salicylic acid (SA), and low-temperature (4 °C) stress. VvZFP10-GFP and VvZFP46-GFP fusion proteins were localized in the nucleus of tobacco cells, and VvZFP10 is the most responsive gene among all VvZFPs with the highest relative expression level to MeJA, ABA, SA and low-temperature (4 °C) stress. The present study provides a theoretical basis for exploring the mechanism of response to exogenous hormones and low-temperature tolerance in grapes and its molecular breeding in the future.
SLC22A11 Inserts the Uremic Toxins Indoxyl Sulfate and P-Cresol Sulfate into the Plasma Membrane
Authors: Tust Maurice , Müller Julian Peter , Fischer Dietmar , Gründemann Dirk
Published: October 2023

Chronic kidney disease (CKD) is a global health concern affecting millions worldwide. One of the critical challenges in CKD is the accumulation of uremic toxins such as p-cresol sulfate (pCS) and indoxyl sulfate (IS), which contribute to systemic damage and CKD progression. Understanding the transport mechanisms of these prominent toxins is essential for developing effective treatments. Here, we investigated whether pCS and IS are routed to the plasma membrane or to the cytosol by two key transporters, SLC22A11 and OAT1. To distinguish between cytosolic transport and plasma membrane insertion, we used a hyperosmolarity assay in which the accumulation of substrates into HEK-293 cells in isotonic and hypertonic buffers was measured in parallel using LC-MS/MS. Judging from the efficiency of transport (TE), pCS is a relevant substrate of SLC22A11 at 7.8 ± 1.4 µL min−1 mg protein−1 but not as good as estrone-3-sulfate; OAT1 translocates pCS less efficiently. The TE of SLC22A11 for IS was similar to pCS. For OAT1, however, IS is an excellent substrate. With OAT1 and p-aminohippuric acid, our study revealed an influence of transporter abundance on the outcomes of the hyperosmolarity assay; very high transport activity confounded results. SLC22A11 was found to insert both pCS and IS into the plasma membrane, whereas OAT1 conveys these toxins to the cytosol. These disparate transport mechanisms bear profound ramifications for toxicity. Membrane insertion might promote membrane damage and microvesicle release. Our results underscore the imperative for detailed structural inquiries into the translocation of small molecules.
Interactions of Nucleosomes with Acidic Patch-Binding Peptides: A Combined Structural Bioinformatics, Molecular Modeling, Fluorescence Polarization, and Single-Molecule FRET Study
Authors: Oleinikov Pavel D. , Fedulova Anastasiia S. , Armeev Grigoriy A. , Motorin Nikita A. , Singh-Palchevskaia Lovepreet , Sivkina Anastasiia L. , Feskin Pavel G. , Glukhov Grigory S. , Afonin Dmitry A. , Komarova Galina A. , Kirpichnikov Mikhail P. , Studitsky Vasily M. , Feofanov Alexey V. , Shaytan Alexey K.
Published: October 2023

In eukaryotic organisms, genomic DNA associates with histone proteins to form nucleosomes. Nucleosomes provide a basis for genome compaction, epigenetic markup, and mediate interactions of nuclear proteins with their target DNA loci. A negatively charged (acidic) patch located on the H2A-H2B histone dimer is a characteristic feature of the nucleosomal surface. The acidic patch is a common site in the attachment of various chromatin proteins, including viral ones. Acidic patch-binding peptides present perspective compounds that can be used to modulate chromatin functioning by disrupting interactions of nucleosomes with natural proteins or alternatively targeting artificial moieties to the nucleosomes, which may be beneficial for the development of new therapeutics. In this work, we used several computational and experimental techniques to improve our understanding of how peptides may bind to the acidic patch and what are the consequences of their binding. Through extensive analysis of the PDB database, histone sequence analysis, and molecular dynamic simulations, we elucidated common binding patterns and key interactions that stabilize peptide–nucleosome complexes. Through MD simulations and FRET measurements, we characterized changes in nucleosome dynamics conferred by peptide binding. Using fluorescence polarization and gel electrophoresis, we evaluated the affinity and specificity of the LANA1-22 peptide to DNA and nucleosomes. Taken together, our study provides new insights into the different patterns of intermolecular interactions that can be employed by natural and designed peptides to bind to nucleosomes, and the effects of peptide binding on nucleosome dynamics and stability.
Multi-Beam Radar Communication Integrated System Design
Authors: Ma Hao , Wang Jun , Sun Xin , Jin Wenxin
Published: October 2023

In this paper, we propose a multi-beam integrated radar and communication scheme using phased-array antenna, in which the same LFM-BPSK integrated waveform is used for both the radar and the communication beams. In the integrated beam design, the radar beam is periodically scanned in different directions for detection, and the communication beam is periodically manipulated in one direction for communication. The system’s beamforming uses adaptive beamforming technology to achieve radar echoes and communication reception. For the LFM-BPSK integrated waveform used by the system, we propose a method for estimating parameters during communication reception. Through simulation, the proposed beam-pattern design, adaptive beamforming, and parameter estimation scheme can achieve radar and communication functions using phased-array antennas.
Nanocomposites for Photocatalysis
Authors: Perez-Larios Alejandro , Varghese Oomman K.
Published: October 2023

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The Effect of Wood Ash and Soil Applications on the Behavior and Survival of Spodoptera frugiperda (Lepidoptera: Noctuidae) Larvae on Maize
Authors: Maphumulo Nozibusiso , du Plessis Hannalene , Van den Berg Johnnie
Published: October 2023

Cryptic feeding inside maize whorls makes it difficult to control fall armyworm (FAW). Smallholder farmers use alternative methods of control, of which the efficacy is uncertain. We determined the efficacy of wood ash and soil for the control of FAW and recorded its effect on larval preference and ballooning. Maize plants were artificially infested with larvae of different instars and treatments were either soil, wet ash, or dry ash, applied as single preventative or curative applications. Larvae exhibited non-preference for treated leaves in choice tests. The efficacy of treatments varied largely between experiments. Under laboratory conditions, ash treatments resulted in significant mortality of 1st and 5th instars. Dry and wet ash as curative applications for 1st instars resulted in 67 and 66% mortality, respectively, compared to mortality recorded in the control (22%). Under field conditions, survival of 3rd instars on treated plants was low (21–34%), compared to 70% on untreated plants. Due to the high variability in efficacy, the use of these alternative methods does not guarantee effective control. They do, however, have a place in IPM systems if applied as soon as infestations are observed and when larvae as still small. Recommendations on the use of ash and soil as spot treatments against FAW are provided.
Laboratory Insecticide Efficacy Trials of Lethal Harborages for Control of the Common Bed Bug, Cimex lectularius (Hemiptera: Cimicidae)
Authors: Kerdsawang Jutamas , Dang Kai , Chareonviriyaphap Theeraphap , Doggett Stephen L.
Published: October 2023

Over the past two decades, there has been a worldwide resurgence in the bed bugs Cimex lectularius L. and Cimex hemipterus (F.). This is primarily due to insecticide resistance, making bed bug management and eradication challenging and expensive. To address the need for more affordable control solutions, “lethal harborages” were explored. Cardboard squares were treated using insecticidal dusts at different dosage levels, including silica dioxide, diatomaceous earth, deltamethrin, permethrin, and fipronil. Two strains of C. lectularius, one susceptible and one resistant, were allowed to enter the treated harborages, and mortality rates were recorded daily. The silica dioxide products proved to be the most efficacious, consistently achieving 100% mortality between 14–17 d at the highest dose. An artificial environment trial using the “new ChinChex®” formulation of silica dioxide resulted in the complete elimination of bed bugs in the treated harborages within 21 d. These findings suggest that lethal harborages, especially those impregnated with silica dioxide, offer a cost-effective solution that could be incorporated into broader integrated bed bug management strategies. This approach may help alleviate the burden of bed bug infestations in economically disadvantaged communities.
Biomarkers of Postpartum Depression: A Narrative Review
Authors: Modzelewski Stefan , Oracz Aleksandra , Iłendo Kamila , Sokół Aleksandra , Waszkiewicz Napoleon
Published: October 2023

Postpartum depression (PPD) is a disorder that impairs the formation of the relationship between mother and child, and reduces the quality of life for affected women to a functionally significant degree. Studying markers associated with PPD can help in early detection, prevention, or monitoring treatment. The purpose of this paper is to review biomarkers linked to PPD and to present selected theories on the pathogenesis of the disease based on data from biomarker studies. The complex etiology of the disorder reduces the specificity and sensitivity of markers, but they remain a valuable source of information to help clinicians. The biggest challenge of the future will be to translate high-tech methods for detecting markers associated with postpartum depression into more readily available and less costly ones. Population-based studies are needed to test the utility of potential PPD markers.
Reconstructive Procedures of the Auricular Concha after Cutaneous Oncologic Surgery: A Systematic Review
Authors: Moreno-Vazquez Sofia , Antoñanzas Javier , Oteiza-Rius Inés , Redondo Pedro , Salido-Vallejo Rafael
Published: October 2023

Reconstruction of the auricular concha poses a challenge due to its difficult access and limited tissue flexibility; however, there are no recommendations in the literature on which reconstructive technique should be favored for this anatomical site. This systematic review intends to describe and compare the reconstructive techniques used in conchal bowl reconstruction following cutaneous oncologic surgery of this region, with regard to their complications and aesthetic results. In doing so, we aim to identify the best suited reconstructive procedure(s) for the conchal bowl. The six databases searched (PubMed, Scopus, Web of Science, Ovid, SciELO, and CENTRAL) yielded twelve eligible studies that explored the revolving door flap, split-thickness skin grafts (STSG), full-thickness skin grafts (FTSG), second intention healing, the preauricular translocation flap, subcutaneous pedicle grafts, and other local flaps. Qualitative synthesis of the results concluded that the revolving door flap could be the reconstructive procedure of choice for the auricular concha, following skin cancer excision. It has a low risk of necrosis, infection, and postoperative hemorrhage, as well as excellent aesthetic outcomes. STSG may be used as an alternative. Nonetheless, due to the low sample size and the high risk of bias in some studies, further investigations must be conducted on this subject.
Difficulties Experienced by Patients with Knee Osteoarthritis during the Conservative Treatment Process: A Qualitative Study
Authors: Özcan Seçkin , Yurten Hakan
Published: October 2023

Background and Objectives: This study aimed to investigate the difficulties faced by patients with knee osteoarthritis during the conservative treatment process. Materials and Methods: We included twenty-one patients who were diagnosed with knee osteoarthritis and admitted to the orthopedics and traumatology outpatient clinic of the hospital where the researcher worked between January 2022 and April 2022. We interviewed each patient using semi-structured face-to-face interviews. To analyze the interviews, the researcher used the directed content analysis method. Data were analyzed using the NVIVO 10 software package. The authors and the expert trained in qualitative research who generously supported the authors continued the analysis independently of each other until they reached a consensus. Results: After analysis of the interviews held with the participants, the following three main themes emerged: lack of information about conservative treatment, frequent change of physicians, and non-compliance with lifestyle changes. Two sub-themes were identified within the theme of frequent change of physicians: distrusting health personnel, and not being able to make an appointment. In addition, most of the patients were not knowledgeable enough about either the definition of the disease or the treatment process. These patients stated that they were confused because they had to change physicians frequently; thus, they distrusted physicians because each physician they visited made a different plan for the treatment process. Conclusions: At the end of the study, we determined that during the conservative treatment process of patients with knee osteoarthritis, a multidisciplinary approach should be adopted, and orthopedic surgeons, physical therapy and rehabilitation physicians, dietitians, and physiotherapists should be in harmony with the patient. In addition, health personnel should provide patients with detailed information to eliminate questions they have during the conservative treatment process. In order for healthcare team members to establish a trusting relationship between the patients, they should allocate enough time to the patient.
Using Generative Artificial Intelligence Tools in Cosmetic Surgery: A Study on Rhinoplasty, Facelifts, and Blepharoplasty Procedures
Authors: Lim Bryan , Seth Ishith , Kah Skyler , Sofiadellis Foti , Ross Richard J. , Rozen Warren M. , Cuomo Roberto
Published: October 2023

Artificial intelligence (AI), notably Generative Adversarial Networks, has the potential to transform medical and patient education. Leveraging GANs in medical fields, especially cosmetic surgery, provides a plethora of benefits, including upholding patient confidentiality, ensuring broad exposure to diverse patient scenarios, and democratizing medical education. This study investigated the capacity of AI models, DALL-E 2, Midjourney, and Blue Willow, to generate realistic images pertinent to cosmetic surgery. We combined the generative powers of ChatGPT-4 and Google’s BARD with these GANs to produce images of various noses, faces, and eyelids. Four board-certified plastic surgeons evaluated the generated images, eliminating the need for real patient photographs. Notably, generated images predominantly showcased female faces with lighter skin tones, lacking representation of males, older women, and those with a body mass index above 20. The integration of AI in cosmetic surgery offers enhanced patient education and training but demands careful and ethical incorporation to ensure comprehensive representation and uphold medical standards.
Current Evidence for the Use of HIPEC and Cytoreductive Surgery in Gastric Cancer Metastatic to the Peritoneum
Authors: Jain Anish J. , Badgwell Brian D.
Published: October 2023

Gastric cancer (GCa) is an aggressive malignancy, representing the third leading cause of cancer mortality worldwide. The poor prognosis of GCa can be associated with the prevalence of peritoneal metastasis (PM). Current international and national GCa treatment guidelines only recommend palliative treatment options for patients with PM. Since the 1980s there have been multiple single arm trials, randomized controlled trials, and metanalysis investigating the use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with advanced GCa, with or without PM. Results from these studies have been encouraging, with some large-volume centers even incorporating HIPEC into their treatment algorithms for patients with advanced GCa. Additionally, there are several ongoing trials that, when completed, will increase our understanding of the efficacy of CRS & HIPEC in patients with GCa metastatic to the peritoneum. Herein we review the current evidence, ongoing trials, consensus guidelines, and future considerations regarding the use of CRS & HIPEC in patients suffering from GCa with PM.
High-Definition 3D Exoscope in Pediatric Otorhinolaryngology: A Systematic Literature Review
Authors: Gaffuri Michele , di Lullo Antonella Miriam , Trecca Eleonora M. C. , Russo Gennaro , Molinari Giulia , Russo Francesca Yoshie , Albera Andrea , Mannelli Giuditta , Ralli Massimo , Turri-Zanoni Mario
Published: October 2023

This PRISMA-compliant systematic review aimed to investigate the use of and the most common procedures performed with the novel 3D 4K exoscope in surgical pediatric head and neck settings. Methods: Search criteria were applied to PubMed, EMBASE and the Cochrane Review databases and included all studies published up to January 2023 reporting 3D 4K exoscope-assisted surgeries in pediatric patients. After the removal of duplicates, selection of abstracts and full-text articles, and quality assessment, we reviewed eligible articles for number of patients treated, age, surgical procedures, and outcomes. Results: Among 54 potentially relevant records, 5 studies were considered eligible and included in this systematic review, with reported treatment data for 182 patients. The surgical procedures belong to the otologic field (121 cases), head and neck surgery (25 cases) and transoral surgery (36 cases). Exoscopy allowed high quality visualization of anatomical structures during cochlear implantation and during reconstruction in head and neck surgery; moreover, it improved the surgical view of surgeons, spectators and ENT students. Conclusions: The use of 3D 4K exoscopy has shown promising potential as a valuable tool in pediatric ORL-head and neck surgery; nevertheless, further validation of these encouraging outcomes is necessary through larger-scale studies specifically focused on pediatric patients.
Younger Age and Parenchyma-Sparing Surgery Positively Affected Long-Term Health-Related Quality of Life after Surgery for Pancreatic Neuroendocrine Neoplasms
Authors: Milanetto Anna Caterina , Armellin Claudia , Brigiari Gloria , Lorenzoni Giulia , Pasquali Claudio
Published: October 2023

(1) Background: Patients with pancreatic Neuroendocrine Neoplasms (PanNENs) often have a long overall survival. We evaluated determinants of quality of life (QoL) after surgery for PanNENs. (2) Methods: Patients operated on for a PanNEN in our center (1990–2021) received three EORTC QoL questionnaires (QLQ-C30, QLQ-GI.NET21, QLQ-PAN26). Six domains were selected as outcome variables (global QoL, physical function -PF, social function -SF, disease-related worries -DRWs, pain, upper-gastrointestinal (GI) symptoms) and evaluated in relation to the clinical variables. Statistical analysis was performed using R software v 4.2.2. (3) Results: One hundred and four patients enrolled showed a good global QoL (median 83.3). Old age was a determinant of worse global QoL (p 0.006) and worse PF (p 0.003). Multiple comorbidities (p 0.002) and old age (p 0.034) were associated with pain, while male gender was related to better PF (p 0.007) and less pain (p 0.012). Patients who had undergone parenchyma-sparing surgery demonstrated better PF (p 0.037), better SF (p 0.012), and less upper-GI symptoms (p 0.047). At multivariable analysis, age (p 0.005) and type of surgery (p 0.028) were confirmed as determinants of global QoL. (4) Conclusions: In patients operated on for a PanNEN, a good HRQoL is generally reported; notably, younger age and parenchyma-sparing surgery seem to positively affect HRQoL.
Usefulness of Intraductal Placement of a Dumbbell-Shaped Fully Covered Self-Expandable Metal Stent for Post-Cholecystectomy Bile Leaks
Authors: Nakagawa Keito , Matsubara Saburo , Suda Kentaro , Otsuka Takeshi , Oka Masashi , Nagoshi Sumiko
Published: October 2023

Background and aims: In the treatment of post-cholecystectomy bile leaks, endoscopic naso-biliary drainage (ENBD) or biliary stenting using plastic stents is the standard of care. Fully covered self-expandable metal stent (FCSEMS) placement across the sphincter of Oddi is considered a salvage therapy for refractory cases, but pancreatitis and migration are the major concerns. Intraductal placement of a dumbbell-shaped FCSEMS (D-SEMS) could avoid these drawbacks of FCMSESs. In this retrospective study, we investigated the usefulness of intraductal placement of the D-SEMS for post-cholecystectomy bile leaks. Methods: Six patients who underwent intraductal placement of the D-SEMS for post-cholecystectomy bile leaks were enrolled. This method was performed as initial treatment in three patients and as salvage treatment in three ENBD refractory cases. Results: Technical and clinical successes were obtained in 6 (100%) patients and 5 (83%) patients, respectively. One clinically unsuccessful patient required laparoscopic peritoneal lavage. The early adverse event was one case of mild pancreatitis (17%). The median duration of the D-SEMS indwelling was 61 days (42–606 days) with no migration cases, all of which were successfully removed. The median follow-up after index ERCP was 761 (range: 161–1392) days with no cases of recurrent bile leaks. Conclusions: Intraductal placement of the D-SEMS for post-cholecystectomy bile leaks might be safe and effective even in refractory cases.
Enhancing Stiffness, Toughness, and Creep in a 3D-Printed Bio-Based Photopolymer Using Ultra-Low Contents of Nanofibrillated Cellulose
Authors: Barkane Anda , Jurinovs Maksims , Starkova Olesja , Grase Liga , Schmidt Daniel F. , Gaidukovs Sergejs
Published: October 2023

UV-light-assisted additive manufacturing (AM) technologies require bio-based resins that can compete with commercial petroleum-based ones to enable a more sustainable future. This research proposes a significantly improved vegetable oil-based resin reinforced with nanofibrillated cellulose (NFC). The incorporation of ultra-low concentrations (0.1–0.5 wt%) of NFC produced disproportionate enhancements in mechanical performance. Noteworthy, a 2.3-fold increase in strain at the break and a 1.5-fold increase in impact strength were observed with only 0.1 wt% of NFC, while at 0.5 wt%, a 2.7-fold increase in tensile modulus and a 6.2-fold increase in toughness were measured. This is in spite of NFC agglomeration at even the lowest loadings, as observed via examination of fracture surfaces and dynamic mechanical analysis (DMA) Cole–Cole plot analysis. The addition of 0.1 wt% NFC also increased creep resistance by 32% and reduced residual strain by 34% following creep recovery. The Burgers model satisfactorily described the composites’ viscoelastic–viscoplastic behavior within the applied stress levels of 1–3 MPa. The successful development of novel NFC/bio-resin composites with enhanced mechanical performance and long-term stability highlights the potential of these composites to substitute petroleum-based resins in the context of AM resins.
Thermoelectric and Magnetic Properties and Electronic Structure of Solid Solutions CuCr1-xLaxS2
Authors: Korotaev Evgeniy V. , Syrokvashin Mikhail M. , Filatova Irina Yu.
Published: October 2023

The oxidation states of atoms in CuCr1-xLaxS2 (x = 0–0.03) solid solutions were determined using the analysis of Cu2p, Cr2p, S2p, and La3d core level binding energy. The cationic substitution did not significantly affect the charge distribution on matrix elements (Cu, Cr, and S). The oxidation states of the atoms were identified as S2− for sulfur, Cu+ for copper, and Cr3+ for chromium. The cationic substitution in CuCr1-xLaxS2 was found to occur via the isovalent principle. The cationic substitution of CuCrS2 matrix with lanthanum ions led to the enhancement of the Seebeck coefficient comparing CuCr1-xLaxS2 to the initial matrix. The observed enhancement was attributed to the reconstruction of the valence band electronic structure after the cationic substitution. The maximum Seebeck coefficient value of 412 μV/K was measured for CuCr0.985La0.015S2 at 420 K. An increase in the lanthanum concentration to x = 0.03 caused a suppression of the Seebeck coefficient. The synthetic route was found to significantly affect both the magnetic properties and charge carrier concentration. The magnetic properties of CuCr1-xLaxS2 synthesized using metal sulfide reagents cannot be interpreted using the simple isovalent Cr3+ to La3+ cationic substitution model. The defectiveness of the samples and the formation of the impurity CuLaS2 phase could be additional factors that affect the magnetic properties of CuCr1-xLaxS2.
3D Printed and Embedded Strain Sensors in Structural Composites for Loading Monitoring and Damage Diagnostics
Authors: Zhao Dongfang , Liu Xingyu , Meves Jacob , Billings Christopher , Liu Yingtao
Published: October 2023

The development of novel embedded sensors for structural health monitoring (SHM) is crucial to provide real-time assessments of composite structures, ensuring safety, and prolonging their service life. Early damage diagnostics through advanced sensors can lead to timely maintenance, reducing costs and preventing potential catastrophic failures. This paper presents the synthesis, 3D printing, and characterization of novel embedded strain sensors using multi-walled carbon nanotube (MWCNT) -enhanced nanocomposites in fiberglass reinforced composites for potential damage diagnostics and SHM applications. MWCNTs are dispersed within structural epoxy for the additive manufacturing of nanocomposites with piezoresistive sensing capability. The 3D-printed nanocomposite sensors are embedded in fiberglass-reinforced composite laminates. The piezoresistive sensing capabilities of the 3D-printed sensors within composites are characterized by applying different levels of maximum loads and load rates under three-point bending loads. Additionally, the long-term reliability of the developed strain sensors is evaluated up to 1000 cycles. The recorded piezoresistive sensing signals show high sensitivity for the externally applied bending loads with advanced gauge factor up to 100, resulting in potential load sensing capability for in-situ damage diagnostics and real-time SHM for structural composites.
Explainable Image Similarity: Integrating Siamese Networks and Grad-CAM
Authors: Livieris Ioannis E. , Pintelas Emmanuel , Kiriakidou Niki , Pintelas Panagiotis
Published: October 2023

With the proliferation of image-based applications in various domains, the need for accurate and interpretable image similarity measures has become increasingly critical. Existing image similarity models often lack transparency, making it challenging to understand the reasons why two images are considered similar. In this paper, we propose the concept of explainable image similarity, where the goal is the development of an approach, which is capable of providing similarity scores along with visual factual and counterfactual explanations. Along this line, we present a new framework, which integrates Siamese Networks and Grad-CAM for providing explainable image similarity and discuss the potential benefits and challenges of adopting this approach. In addition, we provide a comprehensive discussion about factual and counterfactual explanations provided by the proposed framework for assisting decision making. The proposed approach has the potential to enhance the interpretability, trustworthiness and user acceptance of image-based systems in real-world image similarity applications.
Microstructural and Mechanical Analysis of Seamless Pipes Made of Superaustenitic Stainless Steel Using Cross-Roll Piercing and Elongation
Authors: Murillo-Marrodán Alberto , Gamin Yury , Kaputkina Liudmila , García Eduardo , Aleshchenko Alexander , Derazkola Hamed Aghajani , Pashkov Alexey , Belokon Evgeniy
Published: October 2023

The cross-roll piercing and elongation (CPE) is a forming process performed at high temperatures and high strain rates. The final product quality is strongly dependent on its microstructure. In this study, a finite element method (FEM) model was developed to better understand plastic deformation effects on microstructure during CPE and to analyze alternative thermo-mechanical processing routes. Specific models were used to simulate dynamic and meta-dynamic recrystallization (DRX and MDRX) for the processing of superaustenitic stainless steel (SASS). In addition, the CPE of SASS was investigated experimentally. The microstructure, mechanical properties, and chemical changes of the final product were assessed using optical microscopy, hardness testing, X-ray diffraction, and SEM-EDS. The results revealed higher temperatures and strain rates in the exterior area of the shell after piercing, and MDRX occurred in the whole thickness. However, an average grain size reduction of 13.9% occurred only in the shell middle and inner diameters. During elongation, the highest values of the strain rate and DRX were observed in the inner region, exhibiting a grain size reduction of 38%. Spread in terms of grain size and grain shape anisotropy was found to be less accentuated for tube samples as compared to the pierced shells.
Influence of Six-Degree-of-Freedom Motion of a Large Marine Data Buoy on Wind Speed Monitoring Accuracy
Authors: Li Yunzhou , Yang Fuai , Li Shoutu , Tang Xiaoyu , Sun Xuejin , Qi Suiping , Gao Zhiteng
Published: October 2023

In order to quantitatively analyze the data measurement accuracy of ocean buoys under normal and extreme sea conditions, in this study, we simulated the six-degree-of-freedom motion response of self-designed ocean buoys under different sea conditions based on a separated vortex simulation and the fluid volume method and analyzed the impact of the unsteady motion of buoys on data measurement. The results indicate that under normal sea conditions, the deviation between the numerical method used in this paper and the experimental results is less than 10%. The heaving motion of a buoy is most sensitive to changes in wave conditions. The fluctuation intensity of buoy motion is modulated by the height and wavelength of waves. When the wave height and wavelength are similar to the overall geometric size of a buoy, the wave characteristics of the buoy’s heave, yaw, and pitch motion are significant. In addition, under extreme sea conditions, the movement of the buoy can also cause a deviation in the measured velocity in the transverse flow direction, but the overall deviation is less than 10%. In extreme sea conditions, the wind speed measurement results should be corrected to improve the measurement accuracy of a buoy.
Random Matrix Theory for Sound Propagation in a Shallow-Water Acoustic Waveguide with Sea Bottom Roughness
Authors: Makarov Denis V. , Petrov Pavel S. , Uleysky Michael Yu.
Published: October 2023

The problem of sound propagation in a shallow sea with a rough sea bottom is considered. A random matrix approach for studying sound scattering by the water–bottom interface inhomogeneities is developed. This approach is based on the construction of a statistical ensemble of the propagator matrices that describe the evolution of the wavefield in the basis of normal modes. A formula for the coupling term corresponding to inter-mode transitions due to scattering by the sea bottom is derived. The Weisskopf–Wigner approximation is utilized for the coupling between waterborne and sediment modes. A model of a waveguide with the bottom roughness described by the stochastic Ornstein–Uhlenbeck process is considered as an example. Range dependencies of mode energies, modal cross coherences and scintillation indices are computed using Monte Carlo simulations. It is shown that decreasing the roughness correlation length enhances mode coupling and facilitates sound scattering.