bluuebunny/crossref_metadata_2025 huggingface dataset:
pathCLIP: Detection of Genes and Gene Relations from Biological Pathway Figures through Image-Text Contrastive Learning
Authors: He Fei , Liu Kai , Yang Zhiyuan , Chen Yibo , Hammer Richard D. , Xu Dong , Popescu Mihail
Published: November 2023

In biomedical literature, biological pathways are commonly described through a combination of images and text. These pathways contain valuable information, including genes and their relationships, which provide insight into biological mechanisms and precision medicine. Curating pathway information across the literature enables the integration of this information to build a comprehensive knowledge base. While some studies have extracted pathway information from images and text independently, they often overlook the correspondence between the two modalities. In this paper, we present a pathway figure curation system named pathCLIP for identifying genes and gene relations from pathway figures. Our key innovation is the use of an image-text contrastive learning model to learn coordinated embeddings of image snippets and text descriptions of genes and gene relations, thereby improving curation. Our validation results, using pathway figures from PubMed, showed that our multimodal model outperforms models using only a single modality. Additionally, our system effectively curates genes and gene relations from multiple literature sources. A case study on extracting pathway information from non-small cell lung cancer literature further demonstrates the usefulness of our curated pathway information in enhancing related pathways in the KEGG database.
N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease
Authors: Jörg Marko , Plehn Johanna E. , Kristen Marco , Lander Marc , Walz Lukas , Lietz Christine , Wijns Julie , Pichot Florian , Rojas-Charry Liliana , Wirtz Martin Katja M. , Ruffini Nicolas , Kreim Nastasja , Gerber Susanne , Motorin Yuri , Endres Kristina , Rossmanith Walter , Methner Axel , Helm Mark , Friedland Kristina
Published: November 2023

One mechanism of particular interest to regulate mRNA fate post-transcriptionally is mRNA modification. Especially the extent of m1A mRNA methylation is highly discussed due to methodological differences. However, one single m1A site in mitochondrial ND5 mRNA was unanimously reported by different groups. ND5 is a subunit of complex I of the respiratory chain. It is considered essential for the coupling of oxidation and proton transport. Here we demonstrate that this m1A site might be involved in the pathophysiology of Alzheimer’s disease (AD). One of the pathological hallmarks of this neurodegenerative disease is mitochondrial dysfunction, mainly induced by Amyloid β (Aβ). Aβ mainly disturbs functions of complex I and IV of the respiratory chain. However, the molecular mechanism of complex I dysfunction is still not fully understood. We found enhanced m1A methylation of ND5 mRNA in an AD cell model as well as in AD patients. Formation of this m1A methylation is catalyzed by increased TRMT10C protein levels, leading to translation repression of ND5. As a consequence, here demonstrated for the first time, TRMT10C induced m1A methylation of ND5 mRNA leads to mitochondrial dysfunction. Our findings suggest that this newly identified mechanism might be involved in Aβ-induced mitochondrial dysfunction.
Three-dimensional visualization of blood vessels in human gliomas based on tissue clearing and deep learning
Authors: Wang Xinyue , Yang Xiaodu , He Dian , Luo Yunhao , Huang Qiyuan , Li Ting , Ye Zhaoyu , Ye Chun , Zhang Minglin , Lai Hei Ming , Xu Yingying , Sun Haitao
Published: November 2023

Gliomas, with their intricate and aggressive nature, call for a detailed visualization of their vasculature. While many studies lean towards 2D imaging of thin sections, this method often overlooks the full spatial heterogeneity inherent to tumors. To overcome this limitation, our study melded state-of-the-art techniques, encompassing tissue clearing technology, 3D confocal microscopy imaging, and deep learning-aided vessel extraction, resulting in a comprehensive 3D visualization of glioma vasculature in intact human tissue. Specifically, we treated formalin-fixed thick human glioma tissue sections (500 μ m) with OPTIClear for transparency and subsequently performed immunofluorescent labeling using CD31. Using confocal microscopy, we obtained 3D images of the glioma vasculature. For vessel extraction, we employed a specialized 3D U-Net, enriched with image preprocessing and post-processing methods, and benchmarked its performance against the Imaris software. Our findings indicated that OPTIClear-enabled tissue clearing yielded a holistic 3D representation of immunolabeled vessels in clinical human glioma samples. Impressively, our deep learning technique outshined the traditional Imaris approach in terms of accuracy and efficiency in vessel extraction. Further, discernible variations in vascular metrics, such as mean diameter, branching point count, and volume ratio, were observed between low-grade and high-grade gliomas. In essence, our innovative blend of tissue clearing and deep learning not only enables enhanced 3D visualization of human glioma vasculature but also underscores morphological disparities across glioma grades, potentially influencing pathological grading, therapeutic strategies, and prognostic evaluations.
Gods Lockdown: the effect of the April 2022 Colorado low blizzard on SARS-Cov-2 transmission in the midwest United States
Authors: Strobel Stephenson , Daly Michael
Published: November 2023

Background

Lockdowns have been used as a primary non-pharmaceutical intervention to stop transmission of COVID19. There are many issues with interpreting the causal effects of most of these intentional, policy driven interventions. We leverage a natural experiment to avoid many of these issues to better understand the direct effects of lockdown like conditions on COVID19 transmission.

Methods

We exploit a blizzard that interrupted activity across several midwestern states in April 2022. This blizzard broke records for snowfall and caused economic disruption. We leverage this to create control and treatment counties that were more or less affected by the snowfall. We demonstrate effects using event studies comparing these treatment and control counties.

Results

We find that mobility within treatment counties was severely curtailed as a result of the blizzard relative to control counties. We find cumulative declines in the number of COVID19 cases per country by 400 and cumulative declines in COVID19 deaths by 1 per county over the 30 days after the storm. We find declines in by one per hospitalization due to COVID19.

Conclusions

The April 2022 blizzard caused disruption in activity across the midwest United States akin to a lockdown. It reduced the number of COVID19 cases, deaths, and hospitalizations in treatment counties relative to control counties suggesting that similar policies do limit transmissions of SARS-Cov-2.
Site-occupancy factors in the Debye scattering equation. A theoretical discussion on significance and correctness
Authors: Ferri Fabio , Bossuto Maria Chiara , Anzini Pietro , Cervellino Antonio , Guagliardi Antonietta , Bertolotti Federica , Masciocchi Norberto
Published: November 2023

The Debye scattering equation (DSE) [Debye (1915). Ann. Phys.
351, 809–823] is widely used for analyzing total scattering data of nanocrystalline materials in reciprocal space. In its modified form (MDSE) [Cervellino et al. (2010). J. Appl. Cryst.
43, 1543–1547], it includes contributions from uncorrelated thermal agitation terms and, for defective crystalline nanoparticles (NPs), average site-occupancy factors (s.o.f.'s). The s.o.f.'s were introduced heuristically and no theoretical demonstration was provided. This paper presents in detail such a demonstration, corrects a glitch present in the original MDSE, and discusses the s.o.f.'s physical significance. Three new MDSE expressions are given that refer to distinct defective NP ensembles characterized by: (i) vacant sites with uncorrelated constant site-occupancy probability; (ii) vacant sites with a fixed number of randomly distributed atoms; (iii) self-excluding (disordered) positional sites. For all these cases, beneficial aspects and shortcomings of introducing s.o.f.'s as free refinable parameters are demonstrated. The theoretical analysis is supported by numerical simulations performed by comparing the corrected MDSE profiles and the ones based on atomistic modeling of a large number of NPs, satisfying the structural conditions described in (i)–(iii).
Crystal structure and Hirshfeld surface analysis of a new mononuclear copper(II) complex: [bis(pyridin-2-yl-κN)amine](formato-κO)(m-hydroxybenzoato-κ2
O,O′)copper(II)
Authors: Chaisuriya Wanassanan , Chainok Kittipong , Wannarit Nanthawat
Published: November 2023

A new mononuclear copper(II) complex, [Cu(C7H5O3)(HCO2)(C10H9N3)], containing mixed N- and O-donor ligands, 2,2′-dipyridylamine (dpyam) and m-hydroxybenzoate (m-OHbenz), has been obtained from a solvent mixture. The coordination environment of the CuII ion is distorted square-pyramidal with a [N2O3] coordination set originating from the chelating dpyam and m-OHbenz ligands in the basal plane and the O atom of a formato ligand at the apical position. The crystal structure of the title complex is stabilized by N—H...O, O—H...O, C—H...O hydrogen-bonding, π–π and C—H...π intermolecular interactions, which were quantified by Hirshfeld surface analysis.
Learning goal orientation as a background to project efficiency: the mediating role of impact on the team
Authors: Chies Tawnee , Mazieri Marcos
Published: November 2023

Purpose

The emphasis on short-term by project-based firms (PBFs) implies the adoption of project efficiency and impact on the team as project success drivers in PBFs context. Good performance by employees, as individuals in a team, can be explained by their behaviors, associated with goal orientation theory. Learning and performance orientations are associated with teams’ effectiveness and overall project performance. The purpose of this paper is to analyze the relationships between the dimensions of goal orientation, especially learning orientation, and project efficiency and impact on the team, in PBFs context.

Design/methodology/approach

A quantitative approach was adopted, based on data from a survey of 714 respondents, representing project managers, that turned into a valid sample of 315 composed only by PBFs respondents. The results were analyzed through multiple linear regression and, mainly, mediation analysis methods.

Findings

Performance-avoid orientation is a predictor of project efficiency; performance-prove orientation, a predictor of impact on the team. Learning orientation relates positively to both project success criteria. Project managers should balance/induce the proper orientation within the team, favoring learning orientation according to the results, to have short-term project success in PBFs.

Originality/value

There is a direct relationship between learning orientation and project efficiency, but it is fully mediated by impact on the team, which it was not found in previous studies. This study argues that they are not parallel constructs, constituent parts of equal weight in project success, but that impact on the team precedes project efficiency when learning orientation is considered.
Enablers and impact of social innovation in higher education institutes: a futuristic perspective
Authors: Afsar Bilal , AlGhazali Basheer M.
Published: November 2023

Purpose

Social innovation is a nascent field. Within research on social innovation, the context of higher education has largely been ignored. To better understand social innovation, it is important to explore factors that facilitate social innovation in universities’ context. There is little research on enablers of social innovation in universities and the impacts of social innovation. Therefore, the purpose of this study is to understand the enablers of social innovation in the Saudi Arabian context. Moreover, the impacts of social innovation projects are also explored.

Design/methodology/approach

A qualitative approach was used to carry out this study. Data were collected through semistructured interviews, and content analysis was performed.

Findings

Data revealed that institutional commitment, mission, active collaborations, curriculum, support, training, community university engagement offices, university social impact offices and reward and evaluation were among critical enablers. The impact of social innovation in terms of social, institutional, economic and community specific was also reported.

Originality/value

Research on the enablers and outcomes of social innovation in the higher education context is limited. This study adds to the innovation literature by investigating what processes and factors (enablers) can help universities to engage in social innovation initiatives and what are the outcomes (impact) of engaging in social innovation. Findings of the study have important policy implications.
Interpersonal conflict and psychological well-being at work: the beneficial effects of teleworking and emotional intelligence
Authors: Parent-Lamarche Annick , Saade Sabine
Published: November 2023

Purpose

This cross-sectional study had several objectives. This paper aims to study the direct effect of teleworking on interpersonal conflict, the mediating role that interpersonal conflict can play between teleworking and psychological well-being, the moderating role emotional intelligence (EI) can play between teleworking and interpersonal conflict and whether this moderation effect can, in turn, be associated with psychological well-being (moderated mediation effect).

Design/methodology/approach

Path analyses using Mplus software were performed on a sample of 264 employees from 19 small- and medium-sized organizations.

Findings

While teleworking was associated with lower interpersonal conflict, it was not associated with enhanced psychological well-being. Interestingly, workload seemed to be associated with higher interpersonal conflict, while decision authority and support garnered from one’s supervisor seemed to be associated with lower interpersonal conflict. Teleworking was indirectly associated with higher psychological well-being via interpersonal conflict. Finally, EI played a moderating role between teleworking and lower interpersonal conflict. This was, in turn, associated with higher psychological well-being.

Practical implications

EI is an essential skill to develop in the workplace.

Originality/value

A deepened understanding of the role played by EI at work could help organizations to provide positive work environments, both in person and online. This is especially relevant today, with the continued increase in teleworking practices and the resulting rapidly changing interpersonal relationships.
Understanding legitimacy building in contexts through digital entrepreneurship
Authors: Imiren Efe , Lassalle Paul , Mwaura Samuel , Nicolopoulou Katerina
Published: November 2023

Purpose

This paper, through empirical evidence, presents a framework for exploring how entrepreneurs navigate the challenges of building legitimacy in a digital context. In so doing, this paper goes beyond the seemingly forgone conclusion that legitimacy is important for the entrepreneur's success by focusing on the contextualised mechanisms through which digital legitimacy is built.

Design/methodology/approach

Empirical findings are drawn from semi-structured interviews conducted with 21 digital entrepreneurs in Nigeria, a leading example of the West African context and analysed using a phenomenological approach.

Findings

The paper shows how digital entrepreneurs in a non-Western context draw on an aspect of legitimation in the digital space, and in particular, highlights three mechanisms via which this takes place, namely: digital shielding, digital curating and digital networking. Presented via an inductive approach, the three mechanisms described in the paper provide a scaffold for thinking about and understanding entrepreneurial legitimacy within a contextual framework, which incorporates institutional, cultural and digital dimensions.

Originality/value

This paper contributes to the literature on digital entrepreneurship by empirically identifying and theoretically elaborating themes that are important for understanding how entrepreneurs navigate the challenges of digital entrepreneurship and build entrepreneurial legitimacy in complex contexts.
Economic impact of gain in life expectancy: a case study of India
Authors: Das Sujoy
Published: November 2023

Purpose

Few empirical studies examined the relationship between life expectancy and income in India. This study aims to examine the impact of life expectancy on economic growth in India by incorporating all the major states of India.

Design/methodology/approach

This study is based on secondary data and includes 16 major states of India covering the periods 2000–2014. The author used panel fixed effect model (FEM) to examine the impact of life expectancy on economic growth.

Findings

Empirical analysis revealed a positive trend in life expectancy in India. In association with life expectancy, the author found continuous growth in the elderly population. The result of the FEM shows that gains in life expectancy positively affect economic growth in India. The empirical findings do not support any negative impact of life expectancy gains on economic growth.

Originality/value

This study is the outcome of the independent and original research work of the authors and contributes significantly to the literature on the demography–economic relationship. The findings of this study help the author to understand that life expectancy gain is in no way a constraint, rather the skill and experience of the workforce are crucial to determining economic growth.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-06-2022-0422.
Modelling and performance improvement of an annular grooved thrust air bearing
Authors: Chen Yinan , Huo Dehong , Wang Guorong , Zhong Lin , Gong Zheng
Published: November 2023

Purpose

This paper aims to combine the grooves with an annular air thrust bearing with multi-hole restrictors and discusses the influence of the groove parameters on the bearing performance.

Design/methodology/approach

Four models of aerostatic bearings with grooves of different geometries are established. The pressure distribution, load-carrying capacity (LCC), stiffness and flow characteristics of the flow field in the bearing clearances are obtained by computational fluid dynamics simulation.

Findings

The numerical and simulation results show that air bearing with grooved restrictors can slow down the pressure drop at the air inlet and increase the LCC and stiffness of the bearing. The gas flow in the aerostatic bearing is also studied, and the air vortex in the recess is analyzed.

Originality/value

This research optimizes the structure of the annular air thrust bearing, analyzes the gas vortex in the recess, improves the LCC and stiffness of the bearing and provides a reference for the bearing in the selection of groove parameters.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-01-2023-0006/
Robots trends and megatrends: artificial intelligence and the society
Authors: Molfino Rezia , Cepolina Francesco E. , Cepolina Emanuela , Cepolina Elvezia Maria , Cepolina Sara
Published: November 2023

Purpose

The purpose of this study is to analyze the robot trends of the next generation.

Design/methodology/approach

This paper is divided into two sections: the key modern technology on which Europe's robotics industry has built its foundation is described. Then, the next key megatrends were analyzed.

Findings

Artificial intelligence (AI) and robotics are technologies of major importance for the development of humanity. This time is mature for the evolution of industrial and service robots. The perception of robot use has changed from threading to aiding. The cost of mass production of technological devices is decreasing, while a rich set of enabling technologies is under development. Soft mechanisms, 5G and AI have enabled us to address a wide range of new problems. Ethics should guide human behavior in addressing this newly available powerful technology in the right direction.

Originality/value

The paper describes the impact of new technology, such as AI and soft robotics. The world of work must react quickly to these epochal changes to enjoy their full benefits.
BODIES AGAINST MODERNITY: Politics of Slum Rehabilitations in India
Authors: Jatkar Harshavardhan
Published: November 2023

India continues to modernize, and the legacy of political modernity rooted in the European Enlightenment continues to reify itself in India through the performative practices of the body politic. The body politic is a totalized conceptualization of a society imagined in the form of a body, with real exclusionary effects on those without citizenship rights. This body politic is made real through performances of popular sovereignty, bureaucratic state practices and liberal democratic electoral procedures performed during urban development processes. Ethnographic accounts of politics of slum rehabilitations in Pune show that the modern body politic is indeed performatively practised, and reshaped, by the very bodies that are expected to be alienated for the making of the body politic. Bodies meet one another in different spaces and times and generate the possibility of reshaping the liberal body politic into relational and affective bodily politics. Together, bodies become both the site and the means through which political modernity is reshaped in India.
End‐of‐life care: A retrospective cohort study of older people who died within 48 hours of presentation to the emergency department
Authors: Sweeny Amy L , Alsaba Nemat , Grealish Laurie , May Katya , Huang Ya‐Ling , Ranse Jamie , Denny Kerina J , Lukin Bill , Broadbent Andrew , Burrows Erin , Ranse Kristen , Sunny Linda , Khatri Meghna , Crilly Julia
Published: November 2023

Objectives

To describe the characteristics of, and care provided to, older people who died within 48 h of ED presentation.

Methods

A descriptive retrospective cohort study of people 65 years and older presenting to two EDs in Queensland, Australia, between April 2018 and March 2019. Data from electronic medical records were collected and analysed.

Results

Two hundred and ninety‐five older people who died within 48 h of ED presentation were included. Nearly all arrived by ambulance (92%, n = 272) and 36% (n = 106) were from aged care facilities. Three‐quarters (75%, n = 222) were triaged into the most urgent triage categories (i.e. Australasian Triage Scale; ATS 1/2). Fewer than half were previously independent with mobility (38%, n = 111) and activities of daily living (43%, n = 128). Sixty‐one per cent (n = 181) had a pre‐existing healthcare directive. Twenty‐two per cent (n = 66) died in ED, most commonly due to pneumonia, intracerebral haemorrhage, cardiac arrest and/or sepsis. Over half had one or more ED visits (52%, n = 154) and/or hospital admissions (52%, n = 152) 6 months prior.

Conclusions

Identification of patients at end‐of‐life (EoL) is not always straightforward; consider recent reduction in independence and recent ED visits/hospital admissions. System‐based strategies that span pre‐hospital, ED and in‐patient care are recommended to facilitate EoL pathway implementation and care continuity.
Two‐year outcomes of anti‐reflux mucosectomy in treating gastroesophageal reflux disease: A Chinese prospective cohort study
Authors: Hu Jun Nan , Chen Song Feng , Jia Xing Yu , Luo Yu , Xing Xiang Bin , Tan Nian Di , Zhang Meng Yu , Zhuang Qian Jun , Wang Jin Hui , Xiao Ying Lian
Published: November 2023

Objectives

Anti‐reflux mucosectomy (ARMS) is an emerging and promising endoscopic treatment for gastroesophageal reflux disease (GERD). In the current study we aimed to evaluate the safety and efficacy of ARMS in treating Chinese GERD patients.

Methods

This was a single‐center prospective cohort study. ARMS was performed in GERD patients by an experienced endoscopist. The patients were required to undergo symptom assessment as well as endoscopic examination, high‐resolution manometry (HRM), and impedance‐pH monitoring before and after ARMS.

Results

Twelve patients were enrolled. Follow‐up was completed by all patients at 3 and 6 months, 11 patients at 1 year, and 8 patients at 2 years after ARMS, respectively. Symptom improvement was achieved in 66.7%, 75.0%, 72.7%, and 50.0% of the patients at 3 months, 6 months, 1 year, and 2 years after ARMS, respectively. Postoperative dysphagia was reported by 25.0%, 25.0%, 27.3%, and 25.0% of patients at 3 months, 6 months, 1 year, and 2 years after surgery, none of whom required additional invasive treatment. All patients with preoperative esophagitis healed after ARMS. For impedance‐pH monitoring parameters, number of acidic reflux episodes and the proportion of patients with acid exposure time (AET) >4.0% decreased significantly after ARMS.

Conclusions

ARMS was safe and effective in Chinese GERD patients. The efficacy of ARMS was not short‐term and remained evident throughout the 2‐year follow‐up. Further multicenter studies with larger sample sizes are needed to verify our findings.
Counterfactual evaluation of two Austrian agri‐environmental schemes in 2014–2018
Authors: Uehleke Reinhard , Leonhardt Heidi , Hüttel Silke
Published: November 2023

This article investigates the causal effect of farm participation in two Austrian agri‐environmental schemes (AES), Immergrün (ground cover) and Zwischenfrucht (catch cropping), on fertilizer and plant protection expenditures in the 2014 programming period. Combining European Farm Accountancy Data Network data with information on scheme participation from administrative control data offers identifying farm participation in specific schemes targeted at reducing input intensity. Given the overall small sample, we maximized the utilizable sample size by combining difference‐in‐difference and kernel matching with automated bandwidth selection. To address the remaining post‐matching covariate imbalances, we used double machine learning (DML) techniques for a guided selection of potential confounding covariates. Our results suggest that, given the available sample, we cannot substantiate moderate effects of AES participation, and that guided covariate selection by DML offers no gain over non‐guided covariate selection for the small sample. Our results underline the need to increase the number of farms and the duration in available farm panels to substantiate future counterfactual‐based evaluations of policy.
Efficacy and safety of radiofrequency ablation in the treatment of inoperable patients with pulmonary malignant nodules
Authors: Qie Peng , Xun Xuejiao , Nie Xiaodong , Yin Qifan , Cui Hongshang , Liu Lijun , Wang Huien
Published: November 2023

Background

Radiofrequency ablation (RFA) has been recently applied as an alternative treatment in the patients with pulmonary malignancies. The aim of our study was to assess the incidence of complications and survival rate of RFA for malignant lung nodules, and evaluate the efficacy and safety of RFA in the treatment of inoperable patients with pulmonary malignant nodules.

Methods

The clinical data of 50 patients with primary and metastatic lung malignant nodules treated with RFA from June 2015 and July 2017 in Hebei General Hospital were considered, and the characteristics and clinical data of these patients were analysed. Complications, progression‐free survival and overall survival at 1, 2 and 5 years of these patients were evaluated.

Results

Following the procedure. There were no major complications and deaths during the operation. 26 (52%) patients presented mild‐to‐moderate chest pain that was easily controlled by analgesic drugs. 8 (16%) patients with pneumothorax, 4 (8%) haemoptysis, 6 (12%) pneumonia, 7 (14%) pleural effusion and 1 (2%) postoperative bronchopleural fistula. Needle‐track implantation was observed in 2 (4%) patients. Median progression‐free survival (PFS) was 24.6 months. The PFS at 1, 2, 5 years was 76%, 52% and 20%, respectively. Median overall survival (OS) was 35.5 months. The OS at 1, 2 and 5 years was 80%, 58% and 32%, respectively.

Conclusion

RFA is a safe and effective alternative treatment for the inoperable patients with primary or metastatic pulmonary malignant nodules. The clinical impact and long‐term results of RFA need to be further confirmed in a larger series of patients, and RFA should ideally be compared with surgery.
Using Robson classification to analyze cesarean section and induction rates in relation to changes in the standards of perinatal care in one hospital in Poland
Authors: Węgrzynowska Maria , Baranowska Barbara , Sys Dorota , Kajdy Anna , Karzel Katarzyna , Bączek Grażyna , Szlendak Beata , Tataj‐Puzyna Urszula
Published: November 2023

Background

Poland has one of the highest cesarean birth (CB) rates in Europe. For this study, we used the Robson Ten‐Group Classification System (TGCS) to analyze trends in the induction and CB rates in one hospital in Poland over a period of 11 years. We compare these trends with changes in National Legislative and Medical Guidelines introduced during this time that were aimed at lowering rates of unnecessary medical interventions.

Methods

We conducted a retrospective study including all births after 24 weeks' gestation between 2010 and 2020 from one tertiary hospital (n = 66,716 births). After the deletion of records with missing data, 66,678 births were included in the analysis. All births were classified according to the Robson TGCS. The size, CB rate, and contribution of each group for every year were calculated. Linear regression analyses were used to analyze trends over time.

Results

The total CB rate varied from 29.6% to 33.0% during the study period, with a linear increase of 0.045 percentage points annually (R2 = 0.021; F(1) = 0.189; p = 0.674). This study was considerably lower than the total CB rate for Poland, which rose from 33.9% in 2010 to 45.1% in 2020, increasing at a rate of 1.13 percentage points per year (R2 = 0.93; F(1) = 61.88; p < 0.001). Induction rates among both nulliparous (R1 + R2) and multiparous (R3 + R4) women at term also increased. Study groups R5 (previous cesarean birth), R2 (nulliparous in induced or prelabor cesarean delivery), and R1 (nulliparous women at term with single cephalic pregnancy in spontaneous labor) were the highest contributors to the overall CB rate. The greatest decrease in the CB rate was detected in group R5b (more than one previous CB). None of the groups showed statistically significant increases in CB rates over the study period.

Conclusions

The CB rate in the hospital where the study was conducted was considerably lower than the total CB rate in Poland. When compared with countries with similar CB rates, group R2b (women with nulliparous, prelabor cesarean birth) in our study was considerably larger. More comparisons across different hospital settings in Poland are needed. However, as hospitals are not encouraged to routinely collect the data needed to construct TGCS, such comparisons are very difficult to conduct.
Regular resident becomes aggressive enemy: Diagnosed on cytology
Authors: Joshi Anvitha Lakshminarayan , Pradeep Immanuel , Nigam Jitendra Singh , Arora Abhishek Jagdishchander , Ramamourthy Balaji
Published: November 2023

Actinomycosis, an oral cavity commensal, causes cervicofacial infection in patients associated with an immunosuppression state and local mucosal injuries. Bone involvement by this commensal is rare. In the present case, we report a case of left peri mandibular soft tissue, soft to firm, tender swelling in a 39‐year‐old immunocompetent male diagnosed as Actinomycosis infection on fine needle aspiration cytology (FNAC) and cell block preparation.
Prevalence and pattern of maxillofacial injuries associated with domestic violence: A retrospective study at a major trauma center
Authors: Yari Amir , Fasih Paniz , Bagheri Abbas , Aryanezhad Seyed Sasan , Sani Mohammad Khosousi
Published: November 2023

Background/Aim

This study aimed to analyze the frequency and pattern of maxillofacial injuries associated with domestic violence.

Materials and Methods

Medical records of victims of domestic violence between May 2016 and May 2023 were scrutinized retrospectively. The following data were analyzed: gender and age, history of previous abuse, hospital admission, pregnancy, type of facial injuries, anatomical location of injuries, side of injuries, concomitant injuries, mechanism of impact, treatment modality, and history of drug and alcohol abuse.

Results

Seventy‐eight patients were included, comprising of 75 (96.2%) women and 3 (3.8%) men. Domestic violence was an etiology of 2.7% of all maxillofacial injuries. The mean age was 27.06 ± 5.5 years. 33.3% of cases had a history of previous domestic violence. The assailant was drug addicted in 47.4% of cases. The attacker was the current partner of the victim in 79.5% of the victims. Soft tissue injuries were found in 96.1% of cases. Maxillofacial fracture was observed in 52.6% of victims among which zygoma was the most common (16.7%) followed by the nose and mandible (15.4%). Isolated fracture was observed in 85.3% of patients and 71.8% of the injuries were observed on the left. Concomitant injuries were present in 51.3% of patients with arms/hands being the most frequent (48.7%). Punch (67.9%) constituted the majority of the mechanism of impact. Based on the statistical analysis, punches resulted in significantly higher soft tissue contusion (p = .046), and injuries that required no intervention were significantly higher in punched victims (p = .002).

Conclusion

Maxillofacial soft tissue injuries with or without isolated fracture on the left side of the zygoma, mandibular angle, or nose in association with arms/hands injuries in young adult women could be clues of domestic violence. Appropriate care such as preventive programs for drug or alcohol abuse should be implemented to reduce domestic violence, thereby reducing these injuries.
European gay fathers via surrogacy: Parenting, social support, anti‐gay microaggressions, and child behavior problems
Authors: D'Amore Salvatore , Green Robert‐Jay , Mouton Benedicte , Carone Nicola
Published: November 2023

The present study investigated child behavior problems, parenting styles, coparenting, and couple relationship satisfaction in 67 European gay father families via surrogacy and 67 European heterosexual parent families via unassisted conception, all with children aged 1.5–10 years (M = 3.57 years, SD = 2.09). The two family groups were matched for child age and gender. In the gay father group only, the associations between family anti‐gay microaggressions, family/friend support, and other main variables also were explored. Children of gay fathers had fewer externalizing and internalizing problems compared to children of heterosexual parents. Also, gay fathers reported more effective parenting styles, greater coparenting quality, and higher couple relationship satisfaction compared to heterosexual parents. Overall, child externalizing problems (i.e., aggression, rule‐breaking) and internalizing problems (i.e., anxiety, depression) were more strongly associated with being raised in a heterosexual parent family, more authoritarian parenting, and lower positive coparenting. Specific to the gay father sample, anti‐gay microaggressions experienced by family members were associated with more child internalizing problems, lower positive coparenting, and lower social support from family and friends. These results refute concerns about possible detrimental effects on child development of surrogacy conception or of being raised by gay fathers. The results further suggest that family therapists treating child behavior problems should focus mainly on improving the coparenting relationship, reducing authoritarian/punitive parenting styles, and (for gay father families specifically) coping with anti‐gay microaggressions and lack of social support outside the nuclear family.
Applications of artificial intelligence in dementia
Authors: Kameyama Masashi , Umeda‐Kameyama Yumi
Published: November 2023

The recent evolution of artificial intelligence (AI) can be considered life‐changing. In particular, there is great interest in emerging hot topics in AI such as image classification and natural language processing. Our world has been revolutionized by convolutional neural networks and transformer for image classification and natural language processing, respectively. Moreover, these techniques can be used in the field of dementia. We introduce some applications of AI systems for treating and diagnosing dementia, including image‐classification AI for recognizing facial features associated with dementia, image‐classification AI for classifying leukoaraiosis in MRI images, object‐detection AI for detecting microbleeding in MRI images, object‐detection AI for support care, natural language‐processing AI for detecting dementia within conversations, and natural language‐processing AI for chatbots. Such AI technologies can significantly transform the future of dementia diagnosis and treatment. Geriatr Gerontol Int 2024; 24: 25–30.
Contribution of cosmetic ingredients and skin care textures to emotions
Authors: Roso Alicia , Aubert Arnaud , Cambos Sophie , Vial Francis , Schäfer Julia , Belin Marielle , Gabriel Damien , Bize Cécile
Published: November 2023

Objective

Emotions play an important role in consumers' perception of a sensory experience. The objective of this work was to investigate the ability of basic skin care formulas (i.e. without interference of odour, colour and packaging) and pillar ingredients (i.e. emollients and rheology modifiers) to elicit emotions. Another objective was to track, as claimed by neurocosmetics, the possible effect of formulas to trigger emotions from their direct biochemical effects on the skin.

Methods

Standard methodologies were mobilized, combining subjective and behavioural parameters (i.e. verbatim, prosody and gesture). Sense and Story methodology based on a collection of metaphoric verbatim was conducted after an induction phase. In addition, an experimental electrophysiological real‐time visualization method was tried as a first experience in cosmetics. Finally, the ability of formulations with emotional benefits to modulate the release of neuropeptides by sensory neurons was evaluated on a 3D human model (epidermis co‐cultured with sensory neurons).

Results

Skin care formulas were shown to play a role in emotional potential and the types of emotion generated, while changing one ingredient mostly acted on the intensity of the emotions. Verbatim provided contrasted answers depending on the protocol, highlighting the interest of non‐verbal approaches to detect subtle effects. The in vitro model substantiated physiological effects of skin care formulas with emotional potential on human skin sensory neuron activity.

Conclusion

Emotions were impacted by the change in ingredients and were better captured through non‐verbal methods.
Recognition of nursing qualification and credentialing pathway of Filipino nurses in Finland: A qualitative study
Authors: Cubelo Floro , Langari Maliheh Nekouei Marvi , Jokiniemi Krista , Turunen Hannele
Published: November 2023

Aim

To understand the experiences of Filipino internationally educated nurses (FIENs) on their recognition and credentialing pathway in the recruitment process in Finland.

Background

The nursing shortage in Finland results in the recruitment of internationally educated nurses (IENs) such as those from the Philippines. In the context of migration, IENs experience a rigorous process to become qualified nurses in the destination country.

Methods

A thematic analysis of the secondary data from qualitative interviews was conducted. Ten FIENs (n = 10) were recruited from university hospitals in Finland through purposeful and snowball sampling. The study adhered to the consolidated criteria for reporting qualitative research (COREQ) checklist.

Results

Three main themes were identified. First, pre‐migration victories and predicaments described the experiences of FIENs during the recruitment process and the pathway to acquiring a Registered Nurse qualification. Second, ambiguous integration implied integrating into the workplace while working on the top‐up education programme as a prerequisite to nursing registration. Lastly, migration uncertainty discussed the interest among FIENs to continue practising as Registered Nurses (RNs) in Finland.

Conclusions

Pre‐migration orientation and workplace integration experiences influenced FIENs’ choice to practise as RNs in Finland. The licensure pathway for FIENs required collaboration from various stakeholders in Finnish society. It is recommended to structure the system for the recognition and qualification process of IENs by creating a national model in line with international standards and requirements in collaboration with higher education institutions.

Implication for nursing policy

Recognition of previous education and clinical experience can facilitate the transition to becoming an RN for IENs, but the lack of a clear education model and recognition of foreign nursing qualifications leads to deskilling and hinders IENs from practising. Policies prioritising education and integration into the local healthcare system can facilitate the integration and professional growth of IENs, enabling them to contribute significantly to the healthcare system.
Candidate genes for longitudinal traits under sequential sampling in beef cattle
Authors: Ribeiro Virgínia Mara Pereira , Gouveia Gabriela Canabrava , Toral Fabio Luiz Buranelo
Published: November 2023

Both the measurement age of a longitudinal trait and the common pre‐sampling procedures used in beef cattle herds may affect the identification of a functional candidate gene (FCG) that is potentially associated with a trait. To identify the FCG that takes part in the genetic control of body weight at five different ages in a beef cattle population with and without sequential sampling, the animals were weighed at different measurement events, around 330, 385, 440, 495 and 550 days old. Genetic parameters were estimated for body weight at each age using a single trait (STM) and a random regression model (RRM). In addition, two different databases were used to estimate the genetic parameters: the first (DB100) was formed by all animals that were weighed in the five measurement events, and the second (DB70) has records of the same population, considering that 70% of the heaviest animals were selected after each measurement event. For DB100, genome‐wide association studies (GWAS) were performed with 21,667 SNP markers to identify genomic windows that explained at least 1% of the genetic variance. Additionally, prioritization analyses were performed and FCGs were selected. We associated seven different FCGs with body weight at different ages. Among them, the gene DUSP10 was suggested as FCG in all five ages evaluated. Genetic parameters estimated for body weight using DB100 were similar when STM and RRM were applied. However, when DB70 was used as phenotypic data, there were differences between the two models. When the STM was applied, there were differences between the genetic parameters estimated for body weight when DB100 or DB70 were used as sources of phenotypes, but not for the estimates obtained with RRM. The importance of each gene for animal growth can change at different ages, and different genes may be more relevant to body weight at each different growth stage for beef cattle. Besides, sequential sampling can affect the GWAS results of a longitudinal trait. The age of the animal when a longitudinal trait is measured and pre‐sampling can also contribute to inconsistencies in GWAS results for body weight in beef cattle, depending on the time when that data were collected, and consequently on the identification of FCG between studies, even when models that consider a covariance structure are used.
Evaluation of local movement of Bemisia tabaci MEAM1 and tomato severe rugose virus transmission to tomato plants using marked and unmarked whiteflies
Authors: Franco De Oliveira Felipe , Favara Gabriel Madoglio , Carmo‐Sousa Michele , Lopes João Roberto Spotti , Rezende Jorge Alberto Marques
Published: November 2023

Tomato golden mosaic disease, caused by the tomato severe rugose virus (ToSRV), is one of the most serious tomato diseases. ToSRV is transmitted by the whitefly Bemisia tabaci MEAM1, from a wide range of hosts. Introducing ToSRV in commercial fields probably can occur by transporting the virus from distant locations. However, our hypothesis is that the inoculum causing epidemic development might be related to nearby sources. This study evaluated the short‐range flight distance of B. tabaci MEAM1 (marked with detectable proteins and powder dye), through recaptures in yellow sticky traps, and the transmission of ToSRV by viruliferous B. tabaci MEAM1 to tomato plants placed at increasing distances from a release point. Evaluated whiteflies reached a maximum of 30 m from the release point, and no ToSRV‐infected tomato plants were detected at greater distances. These findings reinforce the suspicion that the epidemic‐supporting source of ToSRV inoculum must be close to commercial cultivation areas. About the efficacy of the type of markers used, of the two protein sources tested (pasteurized chicken egg‐white albumin and commercial soy‐based extracts as sources of albumin and lecithin, respectively), albumin was considered easier to detect. Marking with these proteins or with two dyes (blue or pink) did not affect B. tabaci MEAM1 mortality, although field tests showed that fewer marked than unmarked insects were recaptured. Dye marking was considered more practical because of the ease of detection. The study validates a new tool to understand the movement of B. tabaci MEAM1, based on different marking methods.
Petrogenesis of the Dar al Gani (DaG) 1.1 Ma ejection‐paired olivine‐phyric shergottites and implications for ~470 Ma Martian volcanism
Authors: Aucamp Tarryn , Howarth Geoffrey H. , Peel Chad J. , Costin Gelu , Day James M. D. , le Roux Petrus , Scott James M. , Greshake Ansgar , Bartoschewitz Rainer
Published: November 2023

The Dar al Gani (DaG) olivine‐phyric shergottites share mineralogical and geochemical characteristics, which confirm that these meteorites are derived from a single source. Bulk trace elements (La/Yb—0.12), in situ maskelynite 87Sr/86Sr (~0.7014) and redox estimates (FMQ ~ −2) indicate derivation from a depleted, reduced mantle reservoir; identical to all ~470 Ma shergottites ejected at 1.1 Ma. The DaG shergottites have been variably affected by terrestrial alteration, which precipitated carbonate along fractures and modified bulk‐rock fluid mobile (e.g., Ba) elements. Nonetheless, sufficient data are available to construct a multi‐stage formation model for the DaG shergottites and other 1.1 Ma ejection‐paired shergottites that erupted at ~470 Ma. First, partial melting of a depleted mantle source occurred at 1540 ± 20°C and 1.2 ± 0.1 GPa, equivalent to > ~100 km depth. Then, initial crystallization in a staging chamber at ~85 km depth at the crust–mantle boundary took place, followed by magma evolution and variable incorporation of antecrystic olivine ± orthopyroxene. Subsequently, crystallization of olivine phenocrysts and re‐equilibration of olivine antecrysts occurred within an ascending magma. Finally, magmas with variable crystal loads erupted at the surface, where varied cooling rates produced a range of groundmass textures. This model is similar to picritic flood basalt magmas erupted on Earth.