bluuebunny/crossref_metadata_2025 huggingface dataset:
Realization of Polarization and Malus’s Law Using The Smartphones
Authors: Çolak İ. Ö. , Erol M.
Published: May 2020

This work provides an approach for simplifying and teaching of the confusing topic of Polarisation of light and relating Malus’s Law. Teaching Polarisation and the Malus’s Law are modestly achieved by means of smartphones with a convenient light meter application. The apparatus is designed so that the polarizer, the analyser, the laser light source and the smartphone are precisely aligned on a rail. During the performance, the angle of the analyser is basically varied with respect to the polariser and the transmitted light intensity is measured by the light meter application. The results clearly show that the transmitted light intensity is directly proportional to the squared polarization angle. The approach surely provides accessibility for physics teachers and would help students to learn and internalize Polarisation and relating Malus’s Law in a better manner.
The Role of Malcolm X's Speeches in Solidifying his Autobiography
Authors: Aqeeli Ammar
Published: May 2020

This paper demonstrates how a literary text can be approached through a linguistic framework to enhance one’s reading and interpretation of it. It aims at examining the power of The Autobiography of Malcolm X: As Told to Alex Haley by analyzing the narrator’s description of his early speeches. I draw upon the appraisal framework, and I focus on Malcolm’s utilization of affect, judgment, and appreciation in a number of his speeches that he reported in the book. In those speeches, Malcolm adopts resources from the appraisal framework to align his audience with his position. His performance of affective stance to construct the entire problem of race in America contributed to the success of his book for more than 50 years since its publication.
The Effect of Peer Education on Fear of Childbirth in Pregnant Women: A Randomized Clinical Trial
Authors: Rahmani Roghayeh , Yaghoobi Moghadam Fatemeh , Hadizadeh-Talasaz Fatemeh , Rahmani Mohamad Reza
Published: May 2020

Objectives: The fear of childbirth (FOC) is a common problem in women’s lives. Several interventions were carried out to reduce the fear of delivery during pregnancy. Despite these interventions, the increase in cesarean statistics indicates that routine interventions are not effective in controlling the FOC. Accordingly, the present study investigated the effect of peer education on the degree of FOC in pregnant women. Materials and Methods: This clinical trial was performed on 108 low-risk pregnant women aged 18-35 years old referring to community health centers of Gonabad University of Medical Sciences. The participants were randomly assigned to peer education, discussion, and control groups using block randomization (36 in each group). The peer education and discussion groups included four 2-hour sessions for 4 weeks and a training booklet. In peer education and discussion groups, the training was done by trained counterparts and a specialist, respectively. Finally, the data were analyzed using SPSS software through ANOVA and chi-square tests. Results: The results showed a significant difference between mean scores of the FOC in the 3 groups after the intervention (P=0.007). In addition, the Scheffe test showed a significant difference between peer education and the discussion groups (P=0.013). However, after 4 weeks of intervention, no significant difference was observed in the choice of delivery type in the 3 groups (P=0.122). Conclusions: In general, the interventional therapy program of peer education is effective in decreasing the FOC in pregnant women.
Evaluation of the Prevalence of Human Papillomavirus in Asymptomatic Patients at the Women’s Clinic in Hamadan and Comparing the 2 Methods of Pap Smear and PCR in Detecting the Virus
Authors: Ahmadi Maryam , Azizi Jalilian Farid , Dokhani Negar , Golparian Mitra , Moradi Younes
Published: May 2020

Objectives: Human papillomaviruses (HPVs) are a group of non-enveloped viruses which contain double-stranded DNA, and have widespread prevalence in human populations. The aim of this study was to evaluate the prevalence of HPV in asymptomatic patients at the Women’s Clinic in Hamadan and compare the two techniques of Pap smear and Polymerase chain reaction (PCR) in detecting the virus. Materials and Methods: This epidemiologic study was carried out on 1770 asymptomatic patients at the Women’s Clinic in Hamadan. After collecting the cell samples from the cervical areas, they were placed in a pre-prepared medium by a physician and divided into two sections after being sent to the laboratory; the first part was for Pap smear and the second for PCR. If there was a viral genome, it could be determined by PCR. People who were HPV + were candidates for typing. Results: The results of the present study showed that out of 1770 patients aged between 14 and 60 years, referred to Hamadan health centers, 271 patients (15.31%) had HPV. Among them, the highest number of HPV+ cases belonged to the age group of 31-40 years, with the lowest number belonging to the age group of 15-20 years old. Furthermore, out of 271 HPV + patients, 111 (40.09%) had abnormal Pap smear and more than 90% had HPV infection, while less than 10% had low risk (LR) HPV. Conclusions: The results of this study showed that the prevalence of HPV in Hamadan health centers was relatively high. According to the results of this study, it can be concluded that the use of PCR along with Pap smear can help the patients with diagnosis and better treatment.
A novel TRPM6 variant (c.3179T>A) causing familial hypomagnesemia with secondary hypocalcemia
Authors: Lomelino-Pinheiro Sara , Margarida Bastos , Lages Adriana de Sousa
Published: May 2020

Familial hypomagnesemia with secondary hypocalcemia (FHSH) is a rare autosomal recessive disorder (OMIM# 602014) characterized by profound hypomagnesemia associated with hypocalcemia. It is caused by mutations in the gene encoding transient receptor potential cation channel member 6 (TRPM6). It usually presents with neurological symptoms in the first months of life. We report a case of a neonate presenting with recurrent seizures and severe hypomagnesemia. The genetic testing revealed a novel variant in the TRPM6 gene. The patient has been treated with high-dose magnesium supplementation, remaining asymptomatic and without neurological sequelae until adulthood. Early diagnosis and treatment are important to prevent irreversible neurological damage.

Learning points:

Loss-of-function mutations of TRPM6 are associated with FHSH.

FHSH should be considered in any child with refractory hypocalcemic seizures, especially in cases with serum magnesium levels as low as 0.2 mM.

Normocalcemia and relief of clinical symptoms can be assured by administration of high doses of magnesium.

Untreated, the disorder may be fatal or may result in irreversible neurological damage.
Lista actualizada de la flora marina bentónica de cinco arrecifes coralinos del norte de Veracruz, México
Authors: De la Cruz-Francisco Vicencio , Orduña-Medrano Rosa Estela , González-González Marlene
Published: May 2020

El macrofitobentos marino cumple un papel importante en los arrecifes coralinos, sin embargo, son de los grupos biológicos menos estudiados en el Sistema Arrecifal Lobos-Tuxpan, Veracruz, México (SALT). El objetivo del presente estudio fue actualizar la lista taxonómica de las especies de algas y fanerógamas presentes en los arrecifes Tuxpan, Enmedio, Tanhuijo, Lobos y Oro Verde. Entre el periodo 2014-2018, se realizaron un total de 38 muestreos, las exploraciones fueron en la laguna arrecifal y en las pendientes profundas de los arrecifes mediante buceos errantes. La búsqueda de algas y fanerógamas marinas se realizó en cinco tipos de sustratos: arena, guijarros, rocas coralinas, pastos marinos y zona de corales vivos. Así mismo, el listado taxonómico se complementó con registros de especies reportadas previamente para el SALT. La lista taxonómica actualizada está compuesta por 130 especies: 2 pertenecen a Cyanobacteria, 55 Rhodophyta, 23 Ochrophyta, 48 Chlorophyta y 2 Tracheophyta representadas por Halophila decipiens y Thalassia testudinum. Del total de especies, 28 taxa se citan por primera vez para la zona de estudio. Además, Sphorochnus pedunculatus constituye un nuevo registro para el suroeste del golfo de México. Los sustratos con mayor riqueza de algas fueron rocas coralinas y guijarros. Los arrecifes emergentes Lobos, Enmedio y Tuxpan presentaron mayor riqueza florística. La presente información representa un buen avance en el conocimiento de la flora marina y puede ser de utilidad para la toma de decisiones eficaces en materia de manejo, en especial para las fanerógamas que presentan un estatus de riesgo.
Entre tortugas, canales y árboles talados. Aproximación arqueológica a los procesos industriales manifiestos en Tortuguero, Costa Rica (1871-1950)
Authors: Aguilar Bonilla Mónica , Peytrequín Gómez Jeffrey
Published: May 2020

Como parte de los resultados emanados del proyecto de investigación «Arqueología Industrial: Estado del arte y primer inventario nacional» (código 219-B8-077) de la Universidad de Costa Rica, se presentan los siguientes avances de la temporada de campo 2018 respecto al sitio arqueológico Tortuguero (sigla L-324 Tg). Este trabajo aborda el estudio del pasado reciente (finales del siglo XIX hasta 1970) de una localidad ubicada al norte del litoral Caribe de Costa Rica, ello a partir de sus restos materiales y desde la perspectiva de la arqueología industrial.
Imaginarios y cultura política de una élite costarricense. La construcción del poder simbólico de la familia Jiménez (1810-2010)
Authors: Marchena Sanabria Jorge
Published: May 2020

El presente artículo analiza una parte de la cultura política, imaginarios y habitus de una de las familias de la élite costarricense, los Jiménez; en un periodo comprendido entre 1810 y el 2010, aproximadamente. El argumento central de esta exposición consiste en que los grupos dominantes conforman su poder a largo plazo y que, aparte del uso de diversas estrategias para acrecentar la riqueza material, también juega un papel dominante el poder simbólico, el cual se puede encontrar en las formas en que pactan sus matrimonios, alianzas, la mistificación de sus miembros, las prácticas caritativas, entre otros. Todo esto les permite acumular prestigio, a la vez que intentan legitimar el poder acumulado ante rivales y las clases subalternas. Por último, esta investigación se realizó retomando fuentes de archivos, notas hemerográficas, biografías y notas luctuosas.
Podcasts for Nonformal Learning: Using Social Media for Creating Personal Learning Environments, Personal Learning Networks
Authors: Stonkienė Marija , Janiūnienė Erika
Published: May 2020

The use of second-generation web technology (WEB2) in education is emphasising the role of social media as educational sources. Researchers that are analysing personal learning environments (Schaffert, Kalz, 2009; Dabbagh, Kitsantas, 2012), personal learning networks (Couros, 2010) suggest the importance of social media, although this emphasis is attributed to the collaborative interaction of learners. To comprehensively assess the potential of podcasts as social media in the creation of personal learning environments, personal learning networks, the research described in this article does not restrict the definition of podcasts as the potential of collaboration provided by social media. In this article, attention is directed towards the potential of podcasts in the creation of personal learning environment and personal learning networks. By using integrated information behaviour module analysis to determine if the students of Lithuanian higher education institutions value the potential of informal learning provided by podcasts. To determine if these technologies are used for the formation of personal learning environments, personal learning networks, a discussion group research was conducted. During the research the analysis of participant podcast usage showed there is interaction between media content used for recreation and media content used for formal and informal learning. This means that the participants of the research use podcasts to create personal learning environments. On the other hand, this interaction is minimal, created only by the learners and reasoned by the search of educational podcasts. The analysis of the experiences of the discussion participants revealed that the collaborative interaction between learners involved in the research in searching, sharing and using podcasts in the process of learning is not intensive, it is typically fragmented. This allows to point out that the communities that use podcasts for informal learning are not forming. This shows that the potential of podcasts in creating a learning network is not fulfilled, and that podcasts don’t inspire participatory learning.
Intravascular Ultrasound-guided Versus Angiography-guided Percutaneous Coronary Intervention: Evidence from Observational Studies and Randomized Controlled Trials
Authors: Gao Xiao-Fei , Kong Xiang-Quan , Zuo Guang-Feng , Wang Zhi-Mei , Ge Zhen , Zhang Jun-Jie
Published: May 2020

Coronary angiography has been considered the gold standard for the diagnosis of coronary artery disease and guidance of percutaneous coronary intervention (PCI). However, 2D-projection angiography cannot completely reflect the 3D coronary lumen. Intravascular ultrasound (IVUS) can overcome a number of limitations of coronary angiography by providing more information about the dimensions of the vessel lumen, plaque characteristics, stent deployment, and the mechanisms of device failure. Growing data from observational studies and randomized controlled trials have confirmed the clinical benefit of IVUS guidance during PCI. This article summarizes the evidence regarding IVUS guidance to highlight its advantages and to support the use of IVUS during PCI.
Proximal Side Optimization: A Modification of the Double Kissing Crush Technique
Authors: Lavarra Francesco
Published: May 2020

Coronary bifurcations with significant lesions >10 mm in the side branch (SB) are likely to require two-stent treatment techniques. To date, double kissing Crush (DK-Crush) stenting has demonstrated higher rates of final kissing balloon inflation and better clinical outcomes. The technical iterations that lead to optimal clinical outcomes have been attributed to the first kissing balloon that repairs the distorted proximal segment and fully expands the orifice of the side stent. One potential caution, which relates to all Crush techniques, is the possibility of the guidewire crossing in an inappropriate position toward the Crushed SB stent. When this occurs, the SB stent may be further Crushed, leaving the ostium uncovered, which potentially negates the benefit of the Crush technique. In our experience, proximal side optimization (PSO) during DK-Crush stenting ensures stent size ‘accommodation’ to the larger vessel diameter in the proximal segment and better strut apposition to the wall, which is particularly important in the ostial segment. The benefits of this additional modification of the established DK-Crush technique are reduction or elimination of the risk of SB stent distortion, increase of the space of optimal wiring, and avoidance of guidewire advancement under the stent struts, even in unfavorable anatomies with extreme angulation. The author describes a step-by-step approach of a proposed PSO technique, which is easy to perform without any additional procedural time or costs.
METHODOLOGY FOR INTRODUCING THE SYSTEM “CLARC OF ENERGY DISTRIBUTION/CLARC OF PROTEIN TRANSFORMATION” AND A PROCESS FOR CALCULATING BY MEAT PRODUCTION FROM LAMBS AND GOAT KIDS
Authors: Penkov D. , Vuchkov A.
Published: May 2020

Introducing a system for recording of the productive effect of energy and protein by their transformation into lamb/kids/small ruminant’s meat. METHODS: The results were obtained in experiment with a 6 male Kalofer longhaired goat kids, slaughtered immediately at weaning at 90 days of age, without a period of intense fattening after weaning (so-called “milky kids”). The kids were rearing in traditional conditions in the real production system. RESULTS: Clarc of energy distribution - CPT (net energy fodder – gross energy meat) - 0.5871 (58.71%) and Clarc of protein transformation – CPT (protein digestible in the intestine fodder – crude protein meat) - 0.1958 (19.58%) have been calculated. CONCLUSIONS: The Clarc of energy distribution and Clarc of protein transformation are indexes for objective calculation of the energy and nutrient transformation between the preliminary and secondary parts of the eco-technical chain “fodder-edible parts of lambs/kids meat”.
BEHAVIOUR OF BEEF BULLS REARED TOGETHER WITH LACTATING COWS AND CALVES ON A PASTURE/MEADOW COMPLEX
Authors: Markov N. , Bozhanska T. , Nedeva I.
Published: May 2020

The behaviour of two groups of two bulls, lactating cows and calves from the Hereford and Limousin breeds was studied in the artificial pasture/meadow complex "Boyadzhievo" owned by the Research Institute of Mountain Stockbreeding and Agriculture on the outskirts of the town of Troyan. The complex is situated at 610 m above sea level, on a flat terrain with traditional grass. The meteorological characteristics of the late spring were studied, behavioural reactions were studied: grazing, rest, movement and acts of aggression. Natural grassland, which is also the main source of food for the animals surveyed in the pasture complex, was rich in plant species, of which the largest share belonged to the group of forbs (55%), followed by the group of cereals (38%) and leguminous (7%) grasses. Atmospheric conditions and the botanical composition of the pasture had an influence on the ethological reactions of the studied animals. It was found that Index for functional activity (IFA) grazing of Hereford bulls was 0.45455 on pastures, cows – 0.46934 at the time of the experiment and those of the Limousin breed - 0.45448, cows 0.47846. The index of functional activity rest in bulls of both breeds on averages 0.50360 and cows 0.48144.The acts of aggression for the research period were comparatively short: for Hereford bulls and cows 40 and 35 minutes respectively, and for the Limousin breed – 39 and 35 min. The most prolonged acts of aggression were those to motor vehicles, cars passing through and birds, and less pronounced were those to humans, dogs and wild game (foxes).
EFFECT OF PHYTOHORMONES AND THEIR DIVERSE CONCENTRATIONS ON REGENERATION OF ROSE (ROSA HYBRIDA L.)
Authors: Amjad Ali Memon , Mangrio Ghulam
Published: May 2020

Roses most important regularly used for ornamental, medicinal and aromatic rationale in the world. The relevance of plant tissue culture technology to produce planting material of rose in masses depends on the availability of an effective regeneration protocol. The present experiment was done to scrutinize for appropriate basal medium of Murashige and Skoog (1962), phytohormones with their diverse concentrations influence for establish In vitro shoot and root induction of rose (Rosa hybrida L.). The statically analysis of variation explain that least days to initiation, number of shoots, length of shoot cm, number of leaves, days taken in root initiation and number of roots were significant @ 5% possibility. Increase evidence viewing that experimental conclusion exhibit that minimum days to initiation, utmost number of shoots bottle-1, shoot length bottle-1 and number of leaves bottle-1 be record within the concentration of MS + NAA 0.5 mgL-1 + BAP 2 mgL-1. Hence forward minimum days taken in root initiation, highest roots number recorded at 1/2MS + NAA 1.0mg/l + IBA 1.0 mg/l respectively. In vitro healthy and complete plantlets successfully were shifted in to different pot mixtures, supreme survival % recorded at Soil+sand+FYM (1:1:1).
EXPLORATION OF THE IMPACT OF THE EXTRACTION PARAMETERS ON BIOLOGICAL ACTIVE SUBSTANCES IN THE EXTRACTS FROM DRIED FRUIT BLACK BLUEBERRY (VACCINIUM MYRTILLUS L.)
Authors: Georgieva A. , Stefanova R. , Krastev Kr.
Published: May 2020

The optimal parameters of the extraction process for the extraction of biologically active substances from the dried fruits of black blueberry have been established and experimentally confirmed. The phenolic complex of the extracts obtained at different parameters of the extraction process was investigated - selection of the extractant; extraction temperature; extraction time and hydromodule. Studied are the extracts obtained at the optimals extraction parameters for total phenols 7,34 g gallic acid / 100 g dry substance, phenolcarboxylic acids 0,61%, flavonoid phenolic compounds 194 mg%, sum anthocyanins 115 mg% and tannins 8,76 g catechin / 100g dry substance. On the basis of the experimental data, the technological regimes of the extraction process were selected. The use of 70% C2H5OH as an extractant is technologically warranted to produce extracts of dried fruits black blueberry with maximum content of phenols, flavonoids, anthocyanins and tannins. Technologically justified extraction temperature is 65-80оС. By increasing the extraction temperature to 80°C, the quantity of anthocyanins in the extracts increases, which positively affects the organoleptic evaluation of the final products. The optimum extraction time is 3-4 hours. During this extraction period, a maximum content of the phenolic complex is obtained. The results obtained suggest that the most advantageous hydromodul for extraction is 1:30
HISTOLOGICAL, PHYSICOCHEMICAL AND MICROBIOLOGICAL CHANGES IN FRESH AND FROZEN/THAWED FISH
Authors: Strateva M. , Penchev G.
Published: May 2020

The production and supply of fish as food is constantly growing worldwide. Various methods are applied to extend its shelf life, one of them being freezing. According to European Union legislation, the state of the food and its treatment must be indicated on the label. If the food had been frozen prior to marketing and then sold thawed, this information must be provided to the consumer by labelling it. Otherwise, this is considered a fraud to the consumer since freezing significantly degrades the quality of fish. Histological, physicochemical and microbiological changes in the muscle tissue of frozen fish occur. Different methods may be applied to distinguish between fresh and frozen and them thawed fish, of which histological examination is a reliable method.
Tapasztalatok egy manualizált csoportos edukációs programmal az osztályos kardiológiai rehabilitációban
Authors: István Tiringer , Alexandra Nagy , Szidalisz Teleki , Nikolett Žilinski , Eszter Szabados
Published: May 2020

Műhelytanulmányunkban egy olyan új szemléletmódot mutatunk be, amelyet az elmúlt években egy kardiológiai rehabilitációs osztályon működtetett standard, manualizált betegedukációs program használata során sajátítottunk el. Az edukáció új szemléletében a betegek képessé tevése alapozza meg azt, hogy mindennapi életükben meg tudják oldani a betegségükhöz kapcsolódó problémákat. Ennek kiindulópontja, hogy a betegek az igényeiknek megfelelő információkat kapnak betegségükről és kezelésükről. A betegséggel kapcsolatos reális attitűdök és adekvát készségek megtanulása olyan edukációs módszereket igényel, amelyek célja a betegek aktív részvételének ösztönzése, a betegséggel kapcsolatos saját elképzelések és tapasztalatok megosztása és megbeszélése. Az aktív részvétel segíti a betegek felelősségvállalását és a megtanult képességek átültetését a mindennapi életükbe. A tanulmány további részében ismertetjük „A koszorúér-betegség oktatási programjá“-t, amely saját betegedukációs gyakorlatunk alapjául szolgált. A program öt egymásra épülő modulból áll. Kialakítása multidiszciplináris együttműködés keretében történt, a kockázati tényezők csökkentésével és az életmód-változtatással foglalkozó részei az egészségmagatartás társas-kognitív folyamatmodelljén alapulnak. Saját tapasztalataink szerint a betegedukációs program működtetését nagymértékben segíti strukturáltsága és részletes kidolgozottsága. Ezek nemcsak fontos feltételei az edukáció minőségének, hanem segítséget adnak az egyes témák megbeszélése során kialakuló csoportdinamikai folyamatok kezeléséhez is. A betegedukációs program standardizált alkalmazása elősegítheti eredményességének és mechanizmusainak empirikus kutatását.
Párkapcsolati mintázatok és kapcsolati elégedettség együtt élő pároknál: az Olson-modell ellenőrzése
Authors: Csilla Lakatos , Júlia Martos , Adrienn Mányai , Tamás Martos
Published: May 2020

Elméleti háttér: A párkapcsolati elégedettség a családi és a párkapcsolati működés egyik legtöbbet kutatott területe, fontos jelzője a párkapcsolatok stabilitásának és minőségének. A párkapcsolat minősége továbbá hatással van az általános jóllétre, a testi és lelki egészségre. Cél: Házas és együtt élő párok párkapcsolati működésének és elégedettségének feltárása David H. Olson családszerkezeti koncepcióját alapul véve. Módszerek: A keresztmetszeti, kérdőíves vizsgálat résztvevői házas és együtt élő párok voltak (n = 282 pár; átlagéletkor: 45,06 ± 9,52 év és 42,74 ± 10,27 év a férfi és női partnereknél). Terápiába járás szempontjából két alminta volt megkülönböztethető: nem jár terápiába 202 pár (71,6%), terápiába jár 80 pár (28,4%). Mérőeszközök: Olson-féle Családi Teszt negyedik verziója (FACES-IV), Kapcsolati Elégedettség Skála (RAS-H) és a szubjektív egészségi állapotra vonatkozó kérdés. Eredmények: Hierarchikus klaszterelemzést végeztünk 282 pár adataival, az Olson-teszt Kohéziós index, Flexibilitás index és Családi kommunikáció dimenzióit alapul véve. Öt klasztert azonosítottunk: (1) „magas női kohézió“, (2) „jól kommunikáló, átlagos működésű“, (3) „gyengén kommunikáló“, (4) „magas férfi kohézió“ és (5) „flexibilis és jól kommunikáló“ klaszterek. A két alminta között elsősorban a „gyengén kommunikáló“ csoport relativ gyakoriságában volt különbség (56,3% vs. 33,2%) a terápiába járó illetve nem járó pároknál. A klaszterekhez tartozó párok összehasonlítása azt mutatta, hogy a klaszterek átlagai statisztikailag jelentős mértékben eltérnek a párkapcsolati elégedettség tekintetében mind a férfi partnerek (F(4) = 11,07; p < 0,002), mind a női partnerek esetében (F(4) = 9,48; p < 0,005), valamint a szexuális elégedettség tekintetében a férfi partnerek (F(4) = 7,66; p < 0,001) és a női partnerek esetében is (F(4) = 6,87; p < 0,001). A klaszterek nem mutattak szignifikáns kapcsolatot a szubjektív egészségi állapottal. Következtetések: Eredményeink arra utalnak, hogy a párkapcsolati elégedettség többféle kapcsolati működésmódban is megélhető. A kiegyensúlyozottan működő, párkapcsolati szempontból elégedett párok közös jellemzője a jó kommunikáció, amely segíti a kohéziót és a flexibilitást, és ezáltal egyensúlyfenntartó szerepet tölt be a párkapcsolatban.
Analisis Hukum Penanganan Pelanggaran Adminitrasi Pemilu/Pemilihan
Authors: Nasir Iqbal
Published: May 2020

Badan Pengawas Pemilu, tidak lain bertujuan agar demokrasi substanstif yang termanifestasi dalam pemilu/pemilihan yang berintegritas dapat dicapai melalui upaya-upaya pencegahan, pengawasan dan terkhusus terkait penanganan pelanggaran pemilu/pemilihan. Akan tetapi dalam menjalankan salah satu kewenangannya yaitu penanganan pelanggaran, masih terdapat kendala yaitu dalam Penanganan Pelanggaran administrasi pemilu maupun pemilihan. Tujuan penulisan ini adalah untuk menganalisis terkait Penanganan Pelanggaran Administrasi Pemilu atau Pemilihan yang ditangani oleh Badan Pengawas Pemilu. Metoode penelitan yang dilakukan dalam melakukan penelitian ini adalah menggunakan Metode Penelitian Kualitatif sehingga fokus terhadap pada fenomena sosial yang terjadi di masyarakat. Metode Pengumpulan data yang digunakan melalui pengumpulan dokumen, observasi dan wawancara melalui pendekatan kualitatif. Hasil penelitian ini menemukan bahwa output/hasil penanganan pelanggaran administrasi Pemilu maupun Pemilihan yang dilakukan oleh Bawaslu memiliki urgensi/kedudukan penting dalam penegakan hukum Pemilu/Pemilihan. Terkai kendala dalam penanganan pelanggaran administrasi Pemilu/Pemilihan, diperlukan suatu evaluasi dan pembenahan dari faktor substansi, faktor struktur, faktor sarana/prasarana dan faktor masyarakat. Seluruh faktor tersebut harus sinergis demi terciptanya suatu system hukum pemilu/pemilihan yang kuat sehingga akan tercipta demokrasi substansial yang didasarkan kepada nilai langsung, umum, bebas, rahasia, jujur, dan adil.
Peran Kepemimpinan Kepala Sekolah Dalam Mengembangkan Kompetensi Pedagogik Guru
Authors: Suroya A.Eri Iman
Published: May 2020

Keberhasilan SMK Bandung Timur dan SMK Bakti Nusantara 666 dalam usaha mencapai SMK unggulan ditunjang oleh visi-misi kepemimpinan kepala sekolah dalam mengelola dan mewujudkan pendidikan yang berkualitas. Kegiatan pembinaan guru dalam bentuk In-House Training dan workshop merupakan program aktualisasi pengembangan kompetensi pedagogik guru di SMK Bandung Timur dan SMK Bakti Nusantara 666, hal tersebut disebabkan lemahnya produktifitas dan efektifitas tenaga pendidik terhadap proses pebelajaran. Metode Penelitian menggunakan pendekatan kualitatif, teknik pengumpulan datanya dilakukan dengan, wawancara mendalam, observasi berperan serta, dan studi dokumentasi. Hasil penelitian secara keseluruhan menunjukkan bahwa; Peran kepemimpinan Kepala Sekolah dalam mengembangkan kompetensi pedagogik guru di SMK Bandung Timur  dan SMK Bakti Nusantara 666 secara teknis maupun proses pelaksanaannya memiliki ragam cara masing-masing, Perencanaan pengembangan kompetensi pedagogik guru mencakup; a) Formulasi rumusan dan tujuan pengembangan, b) strategi/langkahlangkah pengembangan, c) formulasi program pengembangan, d) penentuan waktu dan tempat, e) rencana anggaran, Pelaksanaan pengembangan kompetensi pedagogik adalah kegiatan In-House Training, dan Workshop pengembangan kurikulum KTSP, dilaksanakan oleh sekolah, Evaluasi pengembangan dilakukan dengan; Supervisi (kunjungan kelas), Kegiatan rapat sekolah, Monitoring guru (CCTV). 5) faktor penunjang mencakup Perubahan Kurikulum,Persaingan dunia pendidikan, Kebutuhan masyarakat, Alokasi dana subsidi, dan Kegiatan akreditasi sekolah. Faktor penghambat mencakup anggaran dana terbatas, fasilitas yang kurang, dan keterbatasan waktu
Implementasi Metode Talaqqi Dalam Pembelajaran Tahsin Dan Tahfiz Al-Qur’an
Authors: Rizalludin Azis
Published: May 2020

Penelitian ini dilatarbelakangi adanya tingkat keterampilan siswa dalam membaca al-Qur’an di SDIT Khaira Ummah Tanjungsari yang belum memenuhi indikator  pencapaian yang telah ditetapkan. Hal ini didasari atas pengamatan di lapangan yang peneliti lakukan di kelas III SDIT Khaira Ummah Tanjungsari tahun pelajaran 2016/2017. Terdapat sebanyak 10 siswa (40%) pada kategori tidak lancar membaca al-Qur’an (terbata-bata) dan 8 siswa (32%) berada pada kategori kurang lancar dalam membaca al-Qur’an dari total 25 siswa di kelas 3 SDIT Khaira Ummah Tanjungsari. Penelitian ini bertujuan untuk mendeskripsikan implementasi metode talaqqi dalam pembelajaran tahsin dan tahfiz al-Qur’an (Penelitian di Kelas III SDIT Khaira Ummah Tanjungsari). Yaitu menggambarkan desain pembelajaran tahsin dan tahfiz al-Qur’an dengan menggunakan metode talaqqi, menggambarkan pelaksanaan dan evaluasi pembelajaran tahsin dan tahfiz al-Qur’an dengan menggunakan metode talaqqi di kelas 3 SDIT Khaira Ummah Tanjungsari. penelitian menggunakan pendekatan kualitatif deskriptif dan metode yang digunakan adalah metode deskriptif analisis, sedangkan metode pengumpulan data yang digunakan meliputi observasi, interview atau wawancara, dokumentasi dan studi pustaka. Hasil penelitian ini menunjukan bahwa Desain pembelajaran tahsin dan tahfiz al-Qur’an dengan menggunakan metode talaqqi di SDIT Khaira Ummah Tanjungsari mencakup desain pengaturan guru, pengaturan siswa, pengaturan waktu dan tempat belajar serta desain materi ajar tahsin dan tahfiz al-Qur’an, Pelaksanaan pembelajaran tahsin dan tahfiz al-Qur’an dengan menggunakan metode talaqqi.
Metodologi Tafsir Darul Islam Fillah : Studi Atas Ayat-Ayat Kerasulan
Authors: Fikri Syukur Ismi Lutfi Rijalul
Published: May 2020

Dalam sejarah Islam, kaum muslimin sejak masa Nabi saw. hingga dewasa ini sepakat berpandangan bahwa kenabian dan atau kerasulan berakhir dengan kehadiran Nabi Muhammad saw. Berbeda halnya dengan Darul Islam Fillah, di mana mereka berpandangan bahwa kenabian belum berakhir, begitupun dengan kerasulan. Hal tersebut berdasar di dalam al-Qur’an tidak ditemukan kalimat khatam ar-rasul yang menyatakan bahwa rasul telah berakhir, sementara yang ditemukan hanyalah kalimat khatam an-nabiyyin yang dalam al-Qur’an kalimat tersebut hanya terdapat dalam satu ayat yaitu QS. al-Ahzab [33]: 40. Sedangkan kata khatam sendiri oleh mereka dimaknai dengan banyak arti, yaitu: stempel, cincin, penyempurna dan penutup. Pemaknaan khatam oleh Darul Islam Fillah tersebut tentu saja tidak sejalan dengan doktrin khatam an-nabiyyin yang disimpulkan dari ayat tersebut dan hadits-hadits yang derajatnya mencapai mutawatir, baik lafdzi maupun ma’nawi. Apalagi para pakar qira’ah yang tergabung dalam qira’ah sab’ah yang mutawatir, mayoritas mereka membacanya dengan kasrah (khatim an-nabiyyin), yang berarti penutup para nabi. Sehingga penafsiran kalimat khatam an-nabiyyin harus pula disesuaikan dengan qira’ah khatim an-nabiyyin, yang tidak menyisakan spekulasi pemaknaan khatam itu dengan stempel, cincin, penyempurna, dan lain sebagainya. Melakukan penafsiran dan menganalisa berbagai permasalahan dari al-Qur’an memang merupakan proses ilmiah yang sangat berat. Oleh karena itu, seorang mufassir harus memiliki kelengkapan ilmu, standar dan kriteria, serta parameter guna menjamin kebenaran penafsiran, dan metodologi yang benar guna mengukur tingkat akurasi penafsiran tersebut sesuai dengan maksud dan tujuan al-Qur’an
Pola Komunikasi Penyuluh Agama Islam Di Daerah 3T
Authors: Andrian Bob
Published: May 2020

Daerah Tertinggal, Terluar dan Terdepan (3T) adalah wilayah strategis negara yang mesti diperhatikan. Mengingat banyak sekali isu dan problematika yang terjadi di Daerah 3T, mulai dari krisis moral, akhlak, sampai pada krisis nasionalisme. Faktor utama penyebab problematika tersebut adalah dikarenakan oleh faktor geografis, sosiol dan budaya yang berkembang di Daerah 3T. Kondisi tersebut tentu berdampak pada aspek pengembangan masyarakat, termasuk diantaranya kegiatan penyuluhan sosial keagamaan. Bertujuan untuk mengkaji secara mendalam dan mendeksripsikan Pola Komunikasi Penyuluh Agama Islam di Daerah 3T Kecamatan Sajingan Besar Kabupaten Sambas sesuai dengan tugas dan fungsi pokok, yaitu fungsi Informatif, Edukatif, Konsultatif dan Advokatif.  Adapun untuk menjawab kedua konsep tersebut teori yang digunakan adalah teori arah informasi dan teori atribusi (subjektivitas) dalam proses penyuluhan kepada masyarakat di Daerah 3T Kecamatan Sajingan Besar. Paradigma penelitian yang digunakan adalah naturalistik dengan pendekatan fenomenologi, jenis penelitian kualitatif dengan metode studi kasus. Hasil penelitian berdasarkan tujuan dan fokus masalah dapat disimpulkan bahwa Pola Komunikasi Penyuluh Agama Islam dalam melaksanakan fungsi pokok penyuluhan kepada masyarakat di Daerah 3T Kecamatan Sajingan Besar baik itu fungsi informatif, edukatif, konsultatif dan advokatif.
Komunikasi Spiritual Syekh Muhammad Abdul Gaos Saefulloh Maslul Al-Qodiri An-Naqsyabandi Al-Kamil
Authors: Usman Maman
Published: May 2020

Abah Aos adalah seorang da’i dan mursyid ke 38 pada Tarekat Qodiriyyah Naqsyabandiyyah Suryalaya (TQNS) bertempat di Pesantren Sirnarasa yang terletak di Dusun Cisirri, Desa Ciomas Kecamatan Panjalu Kabupaten Ciamis - Jawa Barat. Abah Aos dikenal sebagai da’i yang memiliki akhlaq yang dicontohkan oleh Rosululloh SAW. baik di lingkungan keluarga, masyarakat, pemerintah. Wilayah aktivitas dakwah Tarekat yang menjadi jalan hidupnya, Abah Aos memperlihatkan kecemerlangan dakwahnya sehingga TQNS diterima oleh semua kalangan lintas madzhab  sampai belahan Amerika..Penelitian ini berpijak pada teori tindakan yang dikemukakan oleh Max Weber. Dengan Metode yang penulis gunakan dalam penelitian ini adalah metode kualitatif, metode penelitian yang digunakan di lapangan mengenai hal-hal yang sedang terjadi dengan inti dari penelitian ini adalah menganalisa tentang Komunikasi Spiritual  Abah Aos dalam gerakan dakwah Tarekat Qodiriyah Naqsabandiyah Suryalaya dengan jenis metode yang digunakan metode kualitatif dengan pendekatan studi fenomenologi. Berdasarkan hasil penelitian dapat diketahui bahwa gerakan dakwah TQNS Abah Aos: secara  Konsep, bahwa inti ajaran TQNS terbagi dalam enam bahasan, yaitu: Semua manusia Muslim adalah calon wali Alloh, ilmu amaliyah, amal ilmiyah, Talqin, Dzikrulloh, Syari’at Tarekat, hakikat dan Ma’rifat. Sikap dakwah TQNS Abah Aos diantaranya ada perkembangan dalam dakwah TQNS antara Abah Sepuh, Abah Anom, dan Abah Aos. Dalam hal talqin Dzikir Abah Aos, memberikannya kepada siapa saja yang sudah berusia 17 tahun tanpa harus meminta talqin. Tradisi, dalam riyadoh dipermudah, hanya diharuskan melaksanakan amaliyah yang tertera dalam buku Amaliyah Mursyid dan amalan-amalan tertentu
Modal manusia dalam prespektif Islam hubungannya dengan Kinerja Perusahaan
Authors: Nurrohman Nurrohman
Published: May 2020

Dalam tulisan ini membahas Penekanan prinsip dan nilai ajaran islam pada variabel-variabel yang sudah populer dalam pandangan atau kajian konvensional. Tampaknya sudah terabaikan dan terlupakan oleh manajer-pemilik muslim padahal itu semua merupakan unsur penting serta sangat berharga dari sumber daya manusia Islam yang memang jarang  di adopsi oleh mereka dalam operasi bisnis yang dijalankannya. Variabel-variabel itu adalah motivasi, pengetahuan, pengalaman dan pelatihan bisnis. Penulisan artikel ini menggunakan metode survei literatur. Penggunaan metode ini dengan memanfaatkan sumber daya perpustakaan dalam memperoleh data, melacak sumber-sumber sebelumnya untuk menyiapkan kerangka kerja teoritis dan mempertajam metodologi. Prinsip-prinsip  yang dipegang seorang modal manusia islam selain untuk meningkatkan produktifitas dalam mencapai laba perusahaan yang maksimal juga mendapatkan ridho Allah swt melalui pekerjaan yang sedang dikerjakannya.
Utilização de têxteis impregnados com antimicrobianos nos serviços de saúde: revisão integrativa
Authors: Schneider Guilherme , Bim Felipe Lazarini , Sousa Álvaro Francisco Lopes de , Watanabe Evandro , Andrade Denise de , Fronteira Inês
Published: May 2020

Objetivo: analisar as evidências existentes sobre a viabilidade de utilizar têxteis impregnados com substâncias antimicrobianas na prevenção e no controle da transmissão microbiana em serviços de saúde. Método: revisão integrativa, utilizando as bases de dados MEDLINE (via PubMed), Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus e Literatura Latino-Americana em Ciências da Saúde (LILACS), sem restrição de idioma e período de publicação. Após a busca na literatura científica, foram selecionados sete estudos para análise quanto ao tipo de têxtil e substância utilizada para a impregnação, a aplicabilidade no serviço de saúde e a redução da carga microbiana. Resultados: nanopartículas de prata e óxido de cobre foram as principais substâncias antimicrobianas utilizadas para a impregnação de têxteis. A utilização desses têxteis pelos pacientes, como roupas de hotelaria e vestuário, demonstrou maior eficácia na redução da carga microbiana em comparação ao uso como uniforme por profissionais de saúde. Conclusão: a utilização de têxteis impregnados com substâncias antimicrobianas, sobretudo pelos pacientes, pode ser considerada uma alternativa viável na prevenção e no controle da transmissão microbiana nos serviços de saúde. Todavia, a implementação destes têxteis, como uniforme para profissionais de saúde, ainda necessita de maiores investigações quanto à redução da carga microbiana na prática clínica.
Molecular Guided Treatments in Gynecologic Oncology: Analysis of a Real-World Precision Cancer Medicine Platform
Authors: Taghizadeh Hossein , Mader Robert M. , Müllauer Leonhard , Aust Stefanie , Polterauer Stephan , Kölbl Heinz , Seebacher Veronika , Grimm Christoph , Reinthaller Alexander , Prager Gerald W.
Published: May 2020

Introduction

Advanced gynecologic cancers have a poor prognosis and constitute a major challenge for adequate treatment strategies. By analyzing and targeting molecular alterations, molecular guided treatments may be a viable option for the treatment of advanced gynecologic cancers.

Patients and Methods

In this single-center, real-world retrospective analysis of our platform for precision cancer medicine (PCM), we describe the molecular profiling of 72 patients diagnosed with different types of advanced gynecologic malignancies. Tumor samples of the patients were examined by next-generation sequencing panel and immunohistochemistry (IHC).

Results

In total, we identified 209 genetic aberrations in 72 patients. The ten most frequent alterations were TP53 (n = 42, 20%), KRAS (n = 14, 6.6%), PIK3CA (n = 11, 5.2%), PIK3R1 (n = 9, 4.3%), ATR (n = 8, 3.8%), PTEN (n = 8, 3.8%), BRCA1 (n = 6, 2.8%), NF1 (n = 4, 1.9%), NOTCH1 (n = 4, 1.9%), and POLE (n = 4, 1.9%), which account for more than half of all molecular alterations (52.6%). In 21 (29.1%) patients only one mutation could be detected, and 44 (61.1%) patients had more than one mutation. No molecular alterations were detected in seven (9.7%) patients. IHC detected expression of phosphorylated mammalian target of rapamycin and epidermal growth factor receptor in 58 (80.6%) and 53 (73.6%) patients, respectively. In over two thirds (n = 49, 68.1%), a targeted therapy was suggested, based on the identified genetic aberrations. The most frequently recommended specific treatment was the combination of everolimus with exemestane (n = 18, 25 %).

Conclusion

Based on our observations, it seems that PCM might be a feasible approach for advanced gynecologic cancers with limited treatment options.

Implications for Practice

Nowadays molecular profiling of advanced gynecologic malignancies is feasible in the clinical routine. A molecular portrait should be done for every patient with an advanced therapy-refractory gynecologic malignancy to offer molecular-based treatment concepts.
Dual Fulvestrant-Trametinib Therapy in Recurrent Low-Grade Serous Ovarian Cancer
Authors: Bussies Parker L. , Schlumbrecht Matthew
Published: May 2020

Low-grade serous ovarian carcinoma (LGSOC) is known to exhibit chemoresistance. Effective treatment options for recurrent disease are few and often limited to hormone antagonism. Combination of endocrine therapies with MEK-inhibitors displays synergism in preclinical ovarian cancer models, however. This brief communication presents the use of combination anti-estrogenic and MEK-inhibitor therapies, fulvestrant and trametinib, as treatment in a heavily pretreated patient with estrogen receptor-positive, recurrent LGSOC. The dual-therapy regimen was well tolerated and appeared to confer 9 months of progression-free survival. Further investigation is warranted to explore this effect.
Tip 1 allerjik reaksiyonların klinik görünümleri
Authors: KALKAN Göknur
Published: May 2020

Atopik
veya anafilaktik tip olarak da adlandırılan Tip I allerjik
reaksiyonları; Ig E aracılı acil hipersensitivite
reaksiyonlarıdır. Alerjen olarak adlandırılan belirli bir
antijene yutma, solunum, enjeksiyon veya doğrudan temas ile tekrar
maruz kalınmasıyla tetiklenen reaksiyonlardır. IgE antikorları,
histamin granülleri içeren mast hücrelerine ve bazofillere
bağlanır. Aynı alerjene daha sonra maruz kalmak, bağlı IgE'nin
degranülasyona yol açmasına ve histamin, lökotrien,
prostaglandinler gibi mediatörlerin salgılanmasına neden olur.
Reaksiyon lokal veya sistemik şekilde görülebilir. Tip I aşırı
duyarlılık reaksiyonları sonucu oluşan klinik tablolar; ürtiker,
anjiyoödem, anafilaksi,atopik egzema, anafilaksi, besin ve ilaç
allerjileri, allerjik astım, allerjik rinit ve allerjik konjonktivit
şeklinde gruplandırılır. Bu derlemenin amacı günlük
dermatoloji pratiğinde sık ve nadir karşılaşığımız tüm tip
1 allerjik reaksiyonların klinik görünümlerini gözden geçirmek
ve bu hastalıkların oluş mekanizmasıyla klinikleri arası
bağlantı kurmak hedeflenmiştir.
Differentiation of iPSC into dopaminergic neurons v1
Authors: Bressan Elisangela
Published: May 2020

Induced pluripotent stem cell (iPSC)-derived dopaminergic neurons is a promising tool to model Parkinson's disease and of great interest for studying disease mechanisms. Our aim is to describe the protocol for differentiation of iPSC into dopaminergic (DA) neurons currently used in our laboratory. The protocol described here is based on a previously published dual-SMAD inhibition protocol (Kriks et al. Nature 2011). Minor modifications were required for the implementation of the protocol in our automated cell culture system (Dhingra et al. JoVE 2020). The differentiation takes 65 days and produces substantial amounts of MAP2 (neuron) and TH (DA neuron) positive cells.
Separation and purification of human PBMC from FRESH BLOOD v1
Authors: Cosentino Marco , Storelli Elisa , Luini Alessandra , LM Legnaro Massimiliano , Rasini Emanuela , Ferrari Marco , Marino Franca
Published: May 2020

Separation and purification of PBMC from FRESH BLOOD: list of published work using this protocol Kustrimovic, N., Comi, C., Magistrelli, L., Rasini, E., Legnaro, M., Bombelli, R., Aleksic, I., Blandini, F., Minafra, B., Riboldazzi, G., Sturchio, A., Mauri, M., Bono, G., Marino, F., & Cosentino, M. (2018). Parkinson's disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients. Journal of neuroinflammation, 15(1), 205. https://doi.org/10.1186/s12974-018-1248-8 Kustrimovic, N., Rasini, E., Legnaro, M., Bombelli, R., Aleksic, I., Blandini, F., Comi, C., Mauri, M., Minafra, B., Riboldazzi, G., Sanchez-Guajardo, V., Marino, F., & Cosentino, M. (2016). Dopaminergic Receptors on CD4+ T Naive and Memory Lymphocytes Correlate with Motor Impairment in Patients with Parkinson's Disease. Scientific reports, 6, 33738. https://doi.org/10.1038/srep33738 Cosentino M., Ferrari M., Kustrimovic N., Rasini E., Marino F. (2015). Influence of dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study in healthy subjects. Human immunology, 76, 10, 747-752. https://doi.org/10.1016/j.humimm.2015.09.032
Intraperitoneal Injection in an Adult Mouse v1
Authors: Institute for Brain Science Allen
Published: May 2020

This protocol describes the general procedure used for intraperitoneal injection in adult mice. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Tris Buffered Saline (TNT) v1
Authors: Institute for Brain Science Allen
Published: May 2020

This protocol is used to prepare Tris Buffered Saline (TNT). 10X TNT is the stock solution used to prepare 1X TNT, which equilibrates tissue and maintains pH in physiological range. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.