bluuebunny/crossref_metadata_2025 huggingface dataset:
Left and right displaced abomasum and abomasal volvulus: comparison of clinical, laboratory and ultrasonographic findings in 1982 dairy cows
Authors: Braun Ueli , Nuss Karl , Reif Sarah , Hilbe Monika , Gerspach Christian
Published: December 2022

Background

Although left and right displacement of the abomasum and abomasal volvulus are well-known disorders of cattle, a comparative evaluation of the clinical, laboratory and ultrasonographic findings of these types of abomasal displacements has not been undertaken. Therefore, the objective of this study was to compare these conditions in a large population of cows. The medical records of 1982 dairy cows with left displaced abomasum (LDA, n = 1341), right displaced absomasum (RDA, n = 338) and abomasal volvulus (AV, n = 303) were searched for the results of clinical, laboratory and ultrasonographic evaluations.

Results

The main clinical findings were an abnormal demeanour in 48.2% of the cows, reduced rumen motility in 89.7% and decreased intestinal motility in 61.1%. Ballottement and simultaneous auscultation and percussion and simultaneous auscultation were positive on the left side in 96.9% of the cows with LDA and on the right in 98.5% of the cows with RDA and in 99.3% of the cows with AV. Ultrasonography was useful for diagnosing LDA in 97.9% of the cows and RDA/AV in 90.2% of the cows. The laboratory findings characteristic of abomasal reflux syndrome varied in severity; 83% of the cows had hypokalaemia, 67% had increased rumen chloride concentration, 67% had an increased base excess and 50% had haemoconcentration. Based on the clinical signs, a definitive diagnosis was made in 75.0% of the cows with LDA and in 22.5% of the cows with RDA/AV. Ultrasonography was required for a definitive diagnosis in another 22.0% of the cows with LDA and in 53.0% of the cows with RDA/AV. Laparotomy or postmortem examination was required for reliable differentiation of RDA and AV.

Conclusions

LDA, RDA and AV differ with respect to the severity and the frequency of several abnormal clinical, laboratory and ultrasonographic findings as well as the methods required for a diagnosis.
Comparison of ozonated water and acidified copper sulphate in prevention of digital dermatitis in dairy cows
Authors: Pirkkalainen Hertta , Döpfer Dörte , Soveri Timo , Kujala-Wirth Minna
Published: December 2022

Digital dermatitis (DD) is the most significant infectious hoof disorder of cattle in Europe. Hoof baths are one of the most common control methods. Copper sulphate and formalin are commonly used in hoof baths, but their use is problematic in many European countries for health, environmental and safety reasons. Ozonated water and acidified copper sulphate were tested as prevention of DD in a 5-month study. Data were derived from 302 hind feet of Holstein and Estonian Red cows (no. of cows = 151) from a commercial dairy farm in Estonia. Altogether 168 hind feet were included in the acidified copper sulphate group and 134 feet in the ozonated water group. Hoof bathing was carried out three days a week (Mon, Wed, Fri) for two months and then two days a week (Mon, Wed) for three and a half months, in both groups. Ozonated water was sprayed on to the digital skin of hind feet of cows twice a day on treatment days, while the cows were eating. The copper sulphate bath consisted of copper sulphate (2%) mixed with an organic acid compound to acidify and ionize the solution. Cows walked through acidified copper sulphate solution twice a day on treatment days as they were exiting the milking parlor. DD negative and DD positive test results in both groups were compared and statistically tested for differences. The copper sulphate solution was more effective than ozonated water at preventing acute DD lesions. A random maximum likelihood model demonstrated that the odds ratio for DD in the ozonated water group was six times higher compared with DD in the acidified copper sulphate group. Most of the cows that were initially without any DD lesions (M0 + no other severe hoof lesion), remained lesion-free in both groups (copper sulphate group 97% and ozonated water group 88%). Despite trial design deficiencies, the findings indicate that acidified copper sulphate was a more effective solution in preventing DD than ozonated water.
Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala
Authors: Tanuma Masato , Niu Misaki , Ohkubo Jin , Ueno Hiroki , Nakai Yuka , Yokoyama Yoshihisa , Seiriki Kaoru , Hashimoto Hitoshi , Kasai Atsushi
Published: December 2022

We recently reported that a neuronal population in the claustrum (CLA) identified under exposure to psychological stressors plays a key role in stress response processing. Upon stress exposure, the main inputs to the CLA come from the basolateral amygdala (BLA); however, the upstream brain regions that potentially regulate both the CLA and BLA during stressful experiences remain unclear. Here by combining activity-dependent viral retrograde labeling with whole brain imaging, we analyzed neurons projecting to the CLA and BLA activated by exposure to social defeat stress. The labeled CLA projecting neurons were mostly ipsilateral, excluding the prefrontal cortices, which had a distinctly labeled population in the contralateral hemisphere. Similarly, the labeled BLA projecting neurons were predominantly ipsilateral, aside from the BLA in the opposite hemisphere, which also had a notably labeled population. Moreover, we found co-labeled double-projecting single neurons in multiple brain regions such as the ipsilateral ectorhinal/perirhinal cortex, entorhinal cortex, and the contralateral BLA. These results suggest that CLA and BLA receive inputs from neuron collaterals in various brain regions during stress, which may regulate the CLA and BLA forming in a stress response circuitry.
SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis
Authors: Liu Xiaoming , Zheng Yongqiang , Xiao Mengqing , Chen Xingyu , Zhu Yuxing , Xu Canxia , Wang Fen , Liu Zexian , Cao Ke
Published: December 2022

Background

Alternative splicing (AS) events are extensively involved in the progression of diverse tumors, but how serine/arginine-rich splicing Factor 10 (SRSF10) behaves in hepatocellular carcinoma (HCC) has not been sufficiently studied. We aimed to determine SRSF10 associated AS mechanisms and their effects on HCC progression.

Methods

The expression of SRSF10 in HCC tissues was examined, and the in vitro and in vivo functions of SRSF10 were investigated. The downstream AS targets were screened using RNA sequencing. The interaction between SRSF10 protein and exclusion of cell division cycle 25 A (CDC25A) mRNA was identified using RNA immunoprecipitation and crosslinking immunoprecipitation q-PCR. The effects of SRSF10 on CDC25A posttranslational modification, subcellular distribution, and protein stability were verified through coimmunoprecipitation, immunofluorescence, and western blotting.

Results

SRSF10 was enriched in HCC tissues and facilitated HCC proliferation, cell cycle, and invasion. RNA sequencing showed that SRSF10 promotes exon 6 exclusion of CDC25A pre-mRNA splicing. As a crucial cell cycle mediator, the exon-skipped isoform CDC25A(△E6) was identified to be stabilized and retained in the nucleus due to the deletion of two ubiquitination (Lys150, Lys169) sites in exon 6. The stabilized isoform CDC25A(△E6) derived from AS had stronger cell cycle effects on HCC tumorigenesis, and playing a more significant role than the commonly expressed longer variant CDC25A(L). Interestingly, SRSF10 activated the carcinogenesis role of CDC25A through Ser178 dephosphorylation to cause nuclear retention. Moreover, CDC25A(△E6) was verified to be indispensable for SRSF10 to promote HCC development in vitro and in vivo.

Conclusions

We reveal a regulatory pattern whereby SRSF10 contributes to a large proportion of stabilized CDC25A(△E6) production, which is indispensable for SRSF10 to promote HCC development. Our findings uncover AS mechanisms such as CDC25A that might serve as potential therapeutic targets to treat HCC.
The comparison between the effects of pain education interventions with online and face-to-face exercise and the control group received biomedical education + standardized physical therapy in patients with chronic nonspecific neck pain during COVID-19: protocol for a parallel-group randomized controlled trial
Authors: Khosrokiani Zohre , Letafatkar Amir , Hadadnezhad Malihe , Sokhanguei Yahya
Published: December 2022

Background

Various psychological issues and serious health concerns during the imposed lockdown by coronavirus disease 2019 (COVID-19) have induced many changes in the treatment of patients. More effective self-management strategies through tele-rehabilitation are suggested to be applied for patients with chronic neck pain to reduce referrals to health cares and disability support through COVID-19. Also, the pain neuroscience education (PNE) approach is an educational method used by health professionals to assist patients in understanding the biology, physiology, and psychosocial factors affecting their pain experience and aligning with the cognitions and beliefs associated with pain and recurrent disability. PNE combined with tele-rehabilitation could be a new solution to encourage patients to manage their condition by themselves and increase the continuity of practice instead of face-to-face sessions.

Objective

This randomized control trial (RCT) aims to investigate the effects of PNE with online and face-to-face exercise interventions, and the control group received biomedical education + standardized physical therapy on neck pain and disability, psychological factors, and function in non-traumatic chronic neck pain.

Methods/design

Patients with non-traumatic chronic neck pain (patient-centered care and active involvement of patients and the public) will be recruited via flyers displayed in hospitals and universities to participate in an RCT with two experimental and one control group designed to investigate the effects of PNE with online and face-to-face exercise interventions, and the control group received biomedical education + standardized physical therapy on neck pain and disability, psychological factors, and function in non-traumatic chronic neck pain. The outcomes will be measured at baseline, after PNE, and after 3 months of an exercise intervention. All outcomes are presented as mean ± SD, and statistical significance was set at α level of < 0.05. The normal distribution of the variables was verified by the Kolmogorov-Smirnov test, following a descriptive analysis.

Discussion

It seems that PNE plus online and face-to-face exercise interventions are appropriate educational models for the treatment of patients with neck pain during COVID-19. Also, online training seems to encourage patients to continue their treatment.

Trial registration

Iranian Registry of Clinical Trials IRCT20150503022068N5. Registered on 09 September 2021
Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults—the TAKEOVER study
Authors: Lithgow Hannah , Johnston Lynsey , Ho Frederick K. , Celis-Morales Carlos , Cobley James , Raastad Truls , Hunter Angus M. , Lees Jennifer S. , Mark Patrick B. , Quinn Terry J. , Gray Stuart R.
Published: December 2022

Background

Regular participation in resistance exercise is known to have broad-ranging health benefits and for this reason is prominent in the current physical activity guidelines. Recovery after such exercise is important for several populations across the age range and nutritional strategies to enhance recovery and modulate post-exercise physiological processes are widely studied, yet effective strategies remain elusive. Vitamin K2 supplementation has emerged as a potential candidate, and the aim of the current study, therefore, is to test the hypothesis that vitamin K2 supplementation can accelerate recovery, via modulation of the underlying physiological processes, following a bout of resistance exercise in young and older adults.

Methods

The current study is a two-arm randomised controlled trial which will be conducted in 80 (40 young (≤40 years) and 40 older (≥65 years)) adults to compare post-exercise recovery in those supplemented with vitamin K2 or placebo for a 12-week period. The primary outcome is muscle strength with secondary outcomes including pain-free range of motion, functional abilities, surface electromyography (sEMG) and markers of inflammation and oxidative stress.

Discussion

Ethical approval has been granted by the College of Medical Veterinary and Life Sciences Ethical Committee at the University of Glasgow (Project No 200190189) and recruitment is ongoing. Study findings will be disseminated through a presentation at scientific conferences and in scientific journals.

Trial registration

ClinicialTrials.gov NCT04676958. Prospectively registered on 21 December 2020.
Ocular Rosacea microBiome Study (ORBS)—sub-microbial versus antibiotic dosing of doxycycline versus placebo in treatment of symptomatic ocular rosacea: study protocol for a parallel-arm randomized clinical trial
Authors: Mahmud Hamidah , Keenan Jeremy D. , Gonzales John , Schallhorn Julie , Chan Matilda , Arnold Benjamin , Cavallino Victoria , Lietman Thomas M. , Doan Thuy , Seitzman Gerami D.
Published: December 2022

Background

Ocular rosacea is common and is often managed with long-term antibiotic treatment. Doxycycline is the most commonly selected antibiotic for the treatment of rosacea. As there is no established standard of care treatment dose for rosacea, prescribed doses of doxycycline vary widely. The FDA classifies 40 mg daily dose of doxycycline for ocular rosacea as sub-microbial in comparison to an antibiotic dose of 200 mg daily. However, this “sub-microbial” dose has never been evaluated in patients with ocular rosacea, and even the sub-microbial dose has potential to alter systemic mucosa flora. Here, we present a randomized controlled trial using RNA sequencing to fully characterize the impact of sub-microbial antibiotic dosing of doxycycline on antimicrobial resistance and bacterial composition of the ocular and gut flora.

Methods

In a triple-masked parallel randomized control trial, patients with ocular rosacea will be randomized to three arms: a 40-mg dose of doxycycline, a 200-mg antibiotic dose of doxycycline, or placebo. Collected rectal and lower eyelid samples will be compared for frequency of antimicrobial resistance genetic determinants and microbiome diversity. A subjective ocular surface disease index survey and objective tear breakup time measurement will be determined.

Discussion

These results will enhance our understanding of the overall systemic impact of long-term systemic sub-microbial antibiotic dosing for the treatment of chronic recurrent ocular inflammatory diseases.

Trial registration

This trial was registered on ClinicalTrials.org (NCT05296837) on March 22, 2022.
The Knee-Fix study: study protocol for a randomised controlled trial evaluating cemented and cementless components in total knee arthroplasty
Authors: Tay Mei Lin , Zeng Nina , Holland Sherina , Bayan Ali , Farrington Bill J. , van Rooyen Rupert , Sharp Rob , Elliott Robert S. J. , Walker Matthew L. , Young Simon W.
Published: December 2022

Background

Total knee arthroplasty (TKA) is an effective procedure for patients with a variety of knee conditions. The main cause of aseptic TKA failure is implant loosening, which has been linked to poor cement mantle quality. Cementless components were introduced to offer better longer-term biological fixation through osseointegration; however, early designs led to increased rate of revision due to a lack of initial press-fit and bony ingrowth. Newer highly porous metal designs may alleviate this issue but randomised data of fully uncemented TKA (tibial, femoral, patella) is lacking. The aim of the Knee-Fix study is to investigate the long-term implant survival and patient outcomes of fully uncemented compared with cemented fixation in TKA. Our study hypothesis was that uncemented TKA would be as clinically reliable and durable as the gold-standard cemented TKA.

Methods

The Knee-Fix study is a two-arm, single-blinded, non-inferiority randomised controlled trial with 160 patients in each arm and follow-up at 6 weeks, 6 months, 12 months, 24 months, 5 years and 10 years. The primary outcome of interest is implant fixation, which will be measured by assessment of postoperative progressive radiolucencies with the Knee Society Total Knee Arthroplasty Roentgenographic Evaluation and Scoring System. Secondary outcome measures are patient-reported outcomes, measured using Oxford Knee Score (OKS), International Knee Society System (IKSS), Forgotten Joint Score-12 (FJS-12), EuroQol (EQ-5D-5L), VAS Pain, Patient Satisfaction Score and Net Promoter Score.

Discussion

While cemented fixation remains the gold standard, a growing proportion of TKA are now implanted cementless. Highly porous metal cementless components for TKA can offer several benefits including potentially improved biological fixation; however, long-term outcomes need further investigation. This prospective study will help discern long-term differences between the two techniques.

Trial registration

Australian New Zealand Clinical Trials Registry ACTRN12616001624471. Registered trial name: Knee-Fix study (Cemented vs Uncemented Total Knee Replacement). Registered on 24 November 2016.
Seasonal variation in abundance and blood meal sources of primary and secondary malaria vectors within Kilombero Valley, Southern Tanzania
Authors: Katusi Godfrey C. , Hermy Marie R. G. , Makayula Samwely M. , Ignell Rickard , Govella Nicodem J. , Hill Sharon R. , Mnyone Ladslaus L.
Published: December 2022

Background

Existing control tools have significantly reduced malaria over the past two decades. However, progress has been stalled due to increased resistance in primary vectors and the increasing role of secondary vectors. This study aimed to investigate the impact of seasonal change on primary and secondary vector abundance and host preference. Understanding the impact of seasonal dynamics of primary and secondary vectors on disease transmission will inform effective strategies for vector management and control.

Methods

Vector abundance was measured through longitudinal collection of mosquitoes, conducted monthly during the wet and dry seasons, in Sagamaganga, a village in the Kilombero Valley, Tanzania. Mosquitoes were collected indoors using CDC light traps and backpack aspirators, and outdoors using resting buckets baited with cattle urine. In addition, a direct measure of host preference was taken monthly using human- and cattle-baited mosquito electrocuting traps. A host census was conducted to provide an indirect measure of host preference together with monthly blood meal source analysis. All collected mosquitoes were assayed for Plasmodium sporozoites.

Results

A total of 2828 anophelines were collected, of which 78.5% and 21.4%, were primary and secondary vectors, respectively. The abundance of the primary vectors, Anopheles arabiensis and Anopheles funestus, and of the secondary vectors varied seasonally. Indirect measures of host preference indicated that all vectors varied blood meal choice seasonally, with the direct measure confirming this for An. arabiensis. All anopheline mosquitoes tested negative for sporozoites.

Conclusions

At the study location, the abundance of both primary and secondary vectors changed seasonally. Indirect and direct measures of host preference demonstrated that An. arabiensis varied from being zoophilic to being more opportunistic during the wet and dry seasons. A similar trend was observed for the other vectors.

Graphical Abstract
Decreased SUV39H1 at the promoter region leads to increased CREMα and accelerates autoimmune response in CD4+ T cells from patients with systemic lupus erythematosus
Authors: Luo Shuangyan , Zhang Huilin , Xie Yuming , Huang Junke , Luo Danhong , Zhang Qing
Published: December 2022

Background

Overproduction of cAMP-responsive element modulator α (CREMα) in total T cells from patients with systemic lupus erythematosus (SLE) can inhibit IL-2 and increase IL-17A. These ultimately promote progression of SLE. This study aims to investigate the expression of CREMα in SLE CD4+ T cells and find out the mechanisms for the regulation of CREMα in SLE CD4+ T cells.

Results

CREMα mRNA was overexpressed in CD4+ T cells from SLE patients. The levels of histone H3 lysine 9 trimethylation (H3K9me3) and suppressor of variation 3–9 homolog 1 (SUV39H1) at the CREMα promoter of SLE CD4+ T cells were markedly decreased. Down-regulating SUV39H1 in normal CD4+ T cells elevated the levels of CREMα, IL-17A, and histone H3 lysine 4 trimethylation (H3K4me3) in the CREMα promoter region, and lowered IL-2, H3K9me3, DNA methylation, and DNA methyltransferase 3a (DNMT3a) enrichments within the CREMα promoter, while no sharp change in SET domain containing 1 (Set1) at the CREMα promoter. Up-regulating SUV39H1 in SLE CD4+ T cells had the opposite effects. The DNA methylation and DNMT3a levels were obviously reduced, and H3K4me3 enrichment was greatly increased at the CREMα promoter of CD4+ T cells from SLE patients. The Set1 binding in the CREMα promoter region upgraded significantly, and knocking down Set1 in SLE CD4+ T cells alleviated the H3K4me3 enrichment within this region, suppressed CREMα and IL-17A productions, and promoted the levels of IL-2, CREMα promoter DNA methylation, and DNMT3a. But there were no obviously alterations in H3K9me3 and SUV39H1 amounts in the region after transfection.

Conclusions

Decreased SUV39H1 in the CREMα promoter region of CD4+ T cells from SLE patients contributes to under-expression of H3K9me3 at this region. In the meantime, the Set1 binding at the CREMα promoter of SLE CD4+ T cells is up-regulated. As a result, DNMT3a and DNA methylation levels alleviate, and H3K4me3 binding increases. All these lead to overproduction of CREMα. Thus, the secretion of IL-2 down-regulates and the concentration of IL-17A up-regulates, ultimately promoting SLE.
Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome
Authors: Asiminas Antonis , Booker Sam A. , Dando Owen R. , Kozic Zrinko , Arkell Daisy , Inkpen Felicity H. , Sumera Anna , Akyel Irem , Kind Peter C. , Wood Emma R.
Published: December 2022

Background

Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the hallmarks of FXS with affected individuals showing extreme difficulty adapting to novel or complex situations. To explore the neural correlates of this cognitive inflexibility, we used a rat model of FXS (Fmr1−/y).

Methods

We recorded from the CA1 in Fmr1−/y and WT littermates over six 10-min exploration sessions in a novel environment—three sessions per day (ITI 10 min). Our recordings yielded 288 and 246 putative pyramidal cells from 7 WT and 7 Fmr1−/y rats, respectively.

Results

On the first day of exploration of a novel environment, the firing rate and spatial tuning of CA1 pyramidal neurons was similar between wild-type (WT) and Fmr1−/y rats. However, while CA1 pyramidal neurons from WT rats showed experience-dependent changes in firing and spatial tuning between the first and second day of exposure to the environment, these changes were decreased or absent in CA1 neurons of Fmr1−/y rats. These findings were consistent with increased excitability of Fmr1−/y CA1 neurons in ex vivo hippocampal slices, which correlated with reduced synaptic inputs from the medial entorhinal cortex. Lastly, activity patterns of CA1 pyramidal neurons were dis-coordinated with respect to hippocampal oscillatory activity in Fmr1−/y rats.

Limitations

It is still unclear how the observed circuit function abnormalities give rise to behavioural deficits in Fmr1−/y rats. Future experiments will focus on this connection as well as the contribution of other neuronal cell types in the hippocampal circuit pathophysiology associated with the loss of FMRP. It would also be interesting to see if hippocampal circuit deficits converge with those seen in other rodent models of intellectual disability.

Conclusions

In conclusion, we found that hippocampal place cells from Fmr1−/y rats show similar spatial firing properties as those from WT rats but do not show the same experience-dependent increase in spatial specificity or the experience-dependent changes in network coordination. Our findings offer support to a network-level origin of cognitive deficits in FXS.
Fitted numerical method for singularly perturbed Burger–Huxley equation
Authors: Daba Imiru T. , Duressa Gemechis F.
Published: December 2022

This paper deals with the numerical treatment of a singularly perturbed unsteady Burger–Huxley equation. We linearize the problem using the Newton–Raphson–Kantorovich approximation method. We discretize the resulting linear problem using the implicit Euler method and specially fitted finite difference method for time and space variables, respectively. We provide the stability and convergence analysis of the method, which is first-order parameter uniform convergent. We present several model examples to illustrate the efficiency of the proposed method. The numerical results depict that the present method is more convergent than some methods available in the literature.
Accessible decision support for sustainable energy systems in developing countries
Authors: Hart Maria C. G. , Eckhoff Sarah , Breitner Michael H.
Published: December 2022

With rising electricity demand through digitization and innovation, the urgency of climate change mitigation, and the recent geopolitical crisis, stakeholders in developing countries face the complex task to build reliable, affordable, and low-emission energy systems. Information inaccessibility, data unavailability, and scarce local expertise are major challenges for planning and transitioning to decentralized solutions. Motivated by the calls for more solution-oriented research regarding sustainability, we design, develop, and evaluate the web-based decision support system NESSI4Dweb+ that is tailored to the needs and capabilities of various stakeholders in developing countries. NESSI4Dweb+ is open access and considers location-specific circumstances to facilitate multi-energy planning. Its applicability is demonstrated with a case study of a representative rural village in southern Madagascar and evaluated through seven interviews with experts and stakeholders. We show that NESSI4Dweb+ can support the achievement of the United Nations Sustainable Development Goals and enable the very prerequisite of digitization: reliable electrification.
The Secrets of a Loyalist Soul
Authors: Chiang Howard
Published: December 2022

In the 1930s, Peking Union Medical College oversaw the most advanced neuropsychiatric unit in China. Li, a married twenty-two-year-old college student, sought treatment there in 1937 for his anxiety disorder. In ten months with therapist Bingham Dai (1899–1996), Li worked out his secret desire for homosexual and extramarital relations. Dai, trained in sociology at the University of Chicago, interpreted Li's condition in terms of the psychology of wartime collaboration. Drawing on this case study, this article accomplishes three objectives. First, it reassesses the historical relationship between psychoanalysis and homosexuality in a non-Western context. The particular dynamics of Sino-Japanese relations advances a rethinking of the global history of sexual science. Second, the essay aims to elucidate the multiple currents of psychodynamic thinking in 1930s China. Dai integrated psychoanalysis into a clinical setting and stressed the unlocking of Chinese cultural factors as the key to successful therapeutic outcome. What distinguished Dai was his interest in the epistemological overlaps between the neo-Freudian and Confucian approaches to social relations and interpersonal dynamics. Finally, the article discusses how Dai's treatment of Li raises subversive questions about the fragile position of the therapist himself, with respect to both sexual orientation and nationalist identification.
Fashioning Women Citizens in al-Fajr
Authors: Peterson Johanna L
Published: December 2022

When Najla Abillama published the first issue of al-Fajr (The Dawn) in Beirut in January 1919, hope infused articles that looked forward to the future of the homeland and its daughters. Key to that future was the home. Using postcolonial literary theory, Stephen Greenblatt’s notion of self-fashioning, and Nan Enstad’s definition of political subjects, this article analyzes a fictional correspondence between Salma and her daughter Mary, published in al-Fajr from late 1919 through 1920. The article argues that these letters marshal the discourse of domesticity—women as educated managers of their homes, children, and husbands—to articulate women’s roles in public, national life. Thus the mother-daughter and husband-wife relationships highlighted in the correspondence fashion women as citizens patriotically devoted to and shaped by the nation, partnered with their fellow citizens for its improvement. This analysis provides a model for reexamining the relationship between the domestic and the national in the interwar women’s press.
Geflüchtete aus der Ukraine in Deutschland: Flucht, Ankunft und Leben
Authors: Brücker Herbert , Kosyakova Yuliya , Schwanhäuser Silvia , Cardozo Silva Adriana R. , Zinn Sabine , Grabka Markus , Niehues Wenke , Tanis Kerstin , Siegert Manuel , Maddox Amrei , Rother Nina , Spieß C. Katharina , Décieux Jean , Schmitz Sophia , Milewski Nadja , Bujard Martin , Ette Andreas , Sauer Lenore
Published: December 2022

Seit Kriegsbeginn sind mehr als eine Million Menschen aus der Ukraine nach Deutschland geflohen. Erste repräsentative Erkenntnisse über deren Lebenssituation und Zukunftspläne ermöglicht die Studie „Geflüchtete aus der Ukraine in Deutschland (IAB-BiB/FReDA-BAMF-SOEP-Befragung)“, eine gemeinsame Studie des Instituts für Arbeitsmarkt- und Berufsforschung (IAB), des Bundesinstituts für Bevölkerungsforschung (BiB), des Forschungszentrums des Bundesamts für Migration und Flüchtlinge (BAMF-FZ) und des Sozio-oekonomischen Panels (SOEP) am Deutschen Institut für Wirtschaftsforschung (DIW Berlin). Es wurden für diese Studie 11.225 geflüchtete Ukrainerinnen und Ukrainer in der Zeit zwischen August und Oktober 2022 befragt.
The Information Value of Distress
Authors: Hilpert Christian , Hirth Stefan , Szimayer Alexander
Published: December 2022

We propose a novel framework for investigating learning dynamics on the debt market. Observing a firm’s survival of apparently distressed periods, the market eliminates asset value estimates that are too low to be consistent with the observed survival. Therefore, the firm’s cost of debt becomes lower for given financials. Relative to a perfect information setting, the firm strategically delays default to benefit from a subsequently lower cost of debt. Default comes as a surprise, as it reveals the currently worst possible asset value as correct. The surprise effect is mitigated for debt with higher performance sensitivity and for lower ex ante information asymmetry.

This paper was accepted by Gustavo Manso, finance.

Funding: This work was supported by Danmarks Frie Forskningsfond [Grant 0133-00087B], Australian Research Council [Grant DP160104737], the Deutsche Forschungsgemeinschaft [Grant 282079427], Fundamental Research Funds for the Central Universities of China [Grant 18wkpy36], and the Danish Finance Institute (DFI).

Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2022.4632 .
Deciphering Conti and the need for effective SOCs
Authors: Goodwin Scott
Published: December 2022

Conti has proven to be one of the most virulent forms of ransomware. It has caused untold damage, and many organisations struggle to combat this kind of threat on their own. This is where a security partner, with an effective and experienced security operations centre (SOC), can play a key role.
The paradox of open innovation in Slovenian firms
Authors: Farčnik Daša , Redek Tjaša , Šlander Sonja
Published: December 2022

Innovation and open innovation are expected to strengthen firm performance. The learning process and inbound activities are particularly important for catch-up countries and firms. The empirical evidence, though, is incomplete and provides inconclusive results. This paper studies the role of open innovation activities in a sample of Slovenian firms. Using a combination of survey data and official registry financial statements data, we investigate the differences in the role of open innovation across firms with different productivity. The results show that open innovation is more important in less productive firms. This is consistent with the theoretical ideas that stress the role of learning, capacity building and knowledge transfer. However, these firms also invest less in open innovation activities, which is a paradox in itself, introducing an important challenge for managers as well as questions for future research.
Metaphor and theory: a case study of astronomy
Authors: Grubic Tonci
Published: December 2022

Metaphors enable the understanding of one thing in terms of another. Although central to reasoning and theorizing, there is limited understanding about their role in theory development. This paper presents a process of metaphorical reasoning that addresses the question of how metaphors support theory development. The process is applied to the case of astronomy, which helps explain why metaphors create reality and why their reality-creating side cannot be separated from their creative side. The paradoxical nature of metaphors means that metaphorical reasoning is an open-ended process. The paper also shows that emergence – a fundamental property of metaphors – explains their paradoxical nature. This same property makes metaphor a compressed interpretation of the world, characterized by the discarding of information. Finally, it is argued that metaphors are abstract intermediaries between senses and experiences. Given that metaphors are central to reasoning and theorizing, it is not surprising that these findings are consonant with what we know about theory (creative, reality-creating, sparse, abstract and open-ended). What is surprising, though, is that the discarding of information seems to be essential for the building of theory. The paper concludes by exploring what this entails for our understanding of theory.
Thickness optimization algorithm to improve multilayer diffractive optical elements performance
Authors: Laborde Victor , Loicq Jérôme , Hastanin Juriy , Habraken Serge
Published: December 2022

The diffractive zone thicknesses of conventional diffractive optical elements (DOEs) are generally obtained using the thin element approximation (TEA). However, the TEA yields inaccurate results in the case of thick multilayer DOEs (MLDOEs). The extended scalar theory (EST) is an alternative thickness optimization method that depends on the diffractive order and the optimization wavelength. We developed an algorithm to research suitable EST input parameters. It combines ray-tracing and Fourier optics to provide a performance estimate for each EST parameter pair. The resulting “best” MLDOE designs for three different material combinations are analyzed using rigorous finite-difference time-domain. Compared to the TEA, the proposed algorithm can provide performing zone thicknesses.
Dysplasia and tumor discrimination in brain tissues by combined fluorescence, Raman, and diffuse reflectance spectroscopies
Authors: Baria Enrico , Giordano Flavio , Guerrini Renzo , Caporalini Chiara , Buccoliero Anna Maria , Cicchi Riccardo , Pavone Francesco Saverio
Published: December 2022

Identification of neoplastic and dysplastic brain tissues is of paramount importance for improving the outcomes of neurosurgical procedures. This study explores the combined application of fluorescence, Raman and diffuse reflectance spectroscopies for the detection and classification of brain tumor and cortical dysplasia with a label-free modality. Multivariate analysis was performed to evaluate classification accuracies of these techniques–employed both in individual and multimodal configuration–obtaining high sensitivity and specificity. In particular, the proposed multimodal approach allowed discriminating tumor/dysplastic tissues against control tissue with 91%/86% sensitivity and 100%/100% specificity, respectively, whereas tumor from dysplastic tissues were discriminated with 89% sensitivity and 86% specificity. Hence, multimodal optical spectroscopy allows reliably differentiating these pathologies using a non-invasive, label-free approach that is faster than the gold standard technique and does not require any tissue processing, offering the potential for the clinical translation of the technology.
Triply-resonant sum frequency conversion with gallium phosphide ring resonators
Authors: Logan Alan D. , Shree Shivangi , Chakravarthi Srivatsa , Yama Nicholas , Pederson Christian , Hestroffer Karine , Hatami Fariba , Fu Kai-Mei C.
Published: December 2022

We demonstrate quasi-phase matched, triply-resonant sum frequency conversion in 10.6-µm-diameter integrated gallium phosphide ring resonators. A small-signal, waveguide-to-waveguide power conversion efficiency of 8 ± 1.1%/mW; is measured for conversion from telecom (1536 nm) and near infrared (1117 nm) to visible (647 nm) wavelengths with an absolute power conversion efficiency of 6.3 ± 0.6%; measured at saturation pump power. For the complementary difference frequency generation process, a single photon conversion efficiency of 7.2%/mW from visible to telecom is projected for resonators with optimized coupling. Efficient conversion from visible to telecom will facilitate long-distance transmission of spin-entangled photons from solid-state emitters such as the diamond NV center, allowing long-distance entanglement for quantum networks.
Multi-color UCNPs/CsPb(Br1-xIx)3 for upconversion luminescence and dual-modal anticounterfeiting
Authors: Li Mingxing , Liu Wenting , Yang Tieshan , Xu Qinfeng , Mu Haifeng , Han Jing , Cao Kunjian , Jiao Mengmeng , Liu Mingliang , Zhang Shufang , Tan Xiaoming , Yang Chuanlu
Published: December 2022

Advanced hybrid materials have attracted extensive attention in optoelectronics and photonics application due to their unique and excellent properties. Here, the multicolor upconversion luminescence properties of the hybrid materials composed of CsPbX3(X = Br/I) perovskite quantum dots and upconversion nanoparticles (UCNPs, core-shell NaYF4:25%Yb3+,0.5%Tm3+@NaYF4) is reported, achieving the upconversion luminescence with stable and bright of CsPbX3 perovskite quantum dots under 980 nm excitation. Compared with the nonlinear upconversion of multi-photon absorption in perovskite, UCNPs/CsPbX3 achieves lower power density excitation by using the UCNPs as the physical energy transfer level, meeting the demand for multi-color upconversion luminescence in optical applications. Also, the UCNPs/CsPbX3 combined with ultraviolet curable resin (UVCR) shows excellent water and air stability, which can be employed as multicolor fluorescent ink for screen printing security labels. Through the conversion strategy, the message of the security labels can be encrypted and decrypted by using UV light and a 980 nm continuous wave excitation laser as a switch, which greatly improves the difficulty of forgery. These findings provide a general method to stimulate photon upconversion and improve the stability of perovskite nanocrystals, which will be better applied in the field of anti-counterfeiting.
Wideband and high-dimensional chaos generation using optically pumped spin-VCSELs
Authors: Zeng Yao , Zhou Pei , Huang Yu , Mu Penghua , Li Nianqiang
Published: December 2022

We propose and numerically demonstrate wideband and high-dimensional chaos signal generation based on optically pumped spin-polarized vertical-cavity surface-emitting lasers (spin-VCSELs). Here, we focus on the chaotic characteristics of spin-VCSELs under two scenarios: one is a spin-VCSEL with optical feedback and the other is optical heterodyning the outputs of two free-running spin-VCSELs. Specifically, we systematically investigate the influence of some key parameters on the chaotic properties, i.e., bandwidth, spectral flatness (SF), time delay signature (TDS), correlation dimension (CD), and permutation entropy (PE), and reveal the route to enhance these properties simultaneously. Our simulation results demonstrate for the first time that spin-VCSELs with simple auxiliary configurations allow for chaos generation with desired properties, including effective bandwidth up to 30 GHz and above, no TDS of greater than 0.2, the flatness of 0.75 and above, and the high complexity/dimensionality over a wide range of parameters under both schemes. Therefore, our study may pave the way for potential applications requiring wideband and high-dimensional chaos.
Embedded racetrack microring resonator sensor based on GeSbSe glasses
Authors: Li Zhiyong , Hou Cheng , Luo Ye , Zhang Wei , Li Lan , Xu Peipeng , Xu Tiefeng
Published: December 2022

In this article, a compact racetrack double microring resonator (MRR) sensor based on Ge28Sb12Se60 (GeSbSe) is investigated. The sensor device consists of a racetrack microring, an embedded small microring, and a strip waveguide. Electron beam lithography (EBL) and dry etching are used to fabricate the device. The compact racetrack double MRR device are obtained with Q-factor equal to 7.17 × 104 and FSR of 24 nm by measuring the transmission spectrum. By measuring different concentrations of glucose solutions, a sensitivity of 297 nm/RIU by linear fitting and an intrinsic limit of detection (iLOD) of 7.40 × 10−5 are obtained. It paves the way for the application of chalcogenide glasses in the field of biosensing.
Wavefront recording plane-like method for polygon-based holograms
Authors: Wang Fan , Blinder David , Ito Tomoyoshi , Shimobaba Tomoyoshi
Published: December 2022

The wavefront recording plane (WRP) method is an algorithm for computer-generated holograms, which has significantly promoted the accelerated computation of point-based holograms. Similarly, in this paper, we propose a WRP-like method for polygon-based holograms. A WRP is placed near the object, and the diffracted fields of all polygons are aggregated in the WRP so that the fields propagating from the polygonal mesh affect only a small region of the plane rather than the full region. Unlike the conventional WRP method used in point-based holograms, the proposed WRP-like method utilizes sparse sampling in the frequency domain to significantly reduce the practical computational kernel size. The proposed WRP-like method and the analytical shading model are used to generate polygon-based holograms of multiple three-dimensional (3D) objects, which are then reproduced to confirm 3D perception. The results indicate that the proposed WRP-like method based on an analytical algorithm is hundreds of times faster than the reference full region sampling case; a hologram with tens of thousands of triangles can be computed in seconds even on a CPU, whereas previous methods required a graphics processing unit to achieve these speeds.
Double-sided telecentric zoom optical system using adaptive liquid lenses
Authors: Li Jingchen , Zhang Kun , Du Jialin , Li Fanxing , Yang Fan , Yan Wei
Published: December 2022

In this paper, the adaptive liquid (AL) lenses are introduced into the double-sided telecentric zoom system, which could greatly decrease the mechanical motion group compared with the traditional zoom system, and only one movable aperture stop (STO) is retained. Firstly, this paper derived the Gaussian brackets used in this system, and we found the appropriate screening method to get the suitable initial structure parameters from the solution space. Then we used the lens module design method to create the initial system. Finally, we used CODEV to further optimize the system, and we got an excellent design result, which controlled the telecentricity of both sides within 0.1°, the distortion was controlled within 0.5%, and the MTF of each zoom configuration above 0.3. This optical system has high application potential and value in the field of precision machine vision. The design method proposed in this article can effectively solve the problem that the zoom system using adaptive liquid lenses lacks the initial structure.
Co-linear common-path shearography with a zero-approaching shear amount and separate control of the spatial carrier for single-shot phase measurement
Authors: Gao Shuai , Xiong Wenze , Shao Qi , Huang Pengfei , Feng Yingjie , Shi Pengyuan , Xiong Jianxuan , Koch Alexander W. , Lu Yifan , Wang Shengjia
Published: December 2022

A co-linear common-path shearography is proposed with spatial phase shift for single-shot phase measurement. The co-linear common-path configuration brings an enhanced robustness and stability of the measuring system, because the two laterally sheared interfering object waves propagate essentially along the same path, which cancels out the disturbance and noise in surroundings. Two functional features, which break through the limitations in conventional co-linear common-path shearography, are proposed and implemented, namely the zero-approaching shear amount and the separate control of the spatial carrier. Seldom shearography configured by co-linear common-path structure possesses with these two features, because the linearly aligned optics restricts the control parameters in regards to the shear amount and the spatial carrier. In the proposed scheme, an intermediate real image plane is created in the linearly aligned light path to address the issue of zero-approaching shear amount. A 4-f imaging system is embedded with an aperture in between to implement a separate control of the spatial carrier. The zero-approaching shear amount provides the sufficiently small shear to make sure the strain or slope field of complex deformation is resolvable. Meanwhile, the separate control of the spatial carrier further guarantees a well-distributed spatial frequency spectrum when the required zero-approaching shear amount is configured.
Multicolor detour phase holograms based on an Al plasmonic color filter
Authors: Khaleghi Seyed Saleh Mousavi , Wen Dandan , Cadusch Jasper , Crozier Kenneth B.
Published: December 2022

The remarkable advances in nanofabrication that have occurred over the last decade present opportunities for the realization of new types of holograms. In this work, for the first time to the best of our knowledge, a method for phase multicolor holograms based on nanohole arrays is described. The nanoholes are in an aluminum film that is interposed between the glass substrate and a silicon dioxide layer. The nanoholes serve as color filters for blue, green, and red wavelengths and provide the necessary phase distribution via the detour phase method. Our nanohole arrays are optimized to maximize the transmission efficiency of the red, green, and blue channels and to minimize the cross-talk between them. We design two multicolor holograms based on these filters and simulate their performance. The results show good fidelity to the desired holographic images. The proposed structure has the advantages of being very compact, of requiring only a simple fabrication method with one lithography step, and of employing materials (aluminum and silicon dioxide) that are compatible with standard CMOS technology.