bluuebunny/crossref_metadata_2025 huggingface dataset:
Overview of Control Algorithm Verification Methods in Power Electronics Systems
Authors: Szcześniak Paweł , Grobelna Iwona , Novak Mateja , Nyman Ulrik
Published: July 2021

The paper presents the existing verification methods for control algorithms in power electronics systems, including the application of model checking techniques. In the industry, the most frequently used verification methods are simulations and experiments; however, they have to be performed manually and do not give a 100% confidence that the system will operate correctly in all situations. Here we show the recent advancements in verification and performance assessment of power electronics systems with the usage of formal methods. Symbolic model checking can be used to achieve a guarantee that the system satisfies user-defined requirements, while statistical model checking combines simulation and statistical methods to gain statistically valid results that predict the behavior with high confidence. Both methods can be applied automatically before physical realization of the power electronics systems, so that any errors, incorrect assumptions or unforeseen situations are detected as early as possible. An additional functionality of verification with the use of formal methods is to check the converter operation in terms of reliability in various system operating conditions. It is possible to verify the distribution and uniformity of occurrence in time of the number of transistor switching, transistor conduction times for various current levels, etc. The information obtained in this way can be used to optimize control algorithms in terms of reliability in power electronics. The article provides an overview of various verification methods with an emphasis on statistical model checking. The basic functionalities of the methods, their construction, and their properties are indicated.
Active Distribution Networks Planning Considering Multi-DG Configurations and Contingency Analysis
Authors: Amjad Bilal , Al-Ja’afreh Mohammad Ahmad A. , Mokryani Geev
Published: July 2021

This paper proposes a novel method for planning active distribution networks (ADNs) with the integration of an active network management (ANM) scheme using coordinated voltage control (CVC) through on-load tap changer (OLTC) transformers. The method was formulated as a security-constrained optimal power flow (SCOPF) problem to minimize total operational costs, which maximizes the utilization of renewable distributed generators (DGs) over a planning horizon. The ANM scheme was applied using OLTC to ensure safe operation and reduce voltage violations in the network. To analyse the impact of ANM, the planning problem was examined both with and without the ANM scheme. Moreover, SCOPF, considering the N-1 line contingency analysis and multi-DG configuration, was implemented to analyse the feasibility of the proposed method and the advantages of ANM under contingency situations. The method was validated on a weakly-meshed 16-bus UK generic distribution system (UKGDS). The results showed that ANM can lower operational costs and maintain network voltage for operation in feasible conditions even in the case of a contingency. Moreover, the ANM scheme mitigated the voltage rise effect caused by DGs and maximized their utilization.
Transforming Access to Clean Energy Technologies in the Global South: Learning from Lighting Africa in Kenya
Authors: Ockwell David , Byrne Robert , Atela Joanes , Chengo Victoria , Onsongo Elsie , Fodio Todd Jacob , Kasprowicz Victoria , Ely Adrian
Published: July 2021

As SDG7-related interventions seek to transform access to clean energy, this paper presents an analysis of both a previous transformative intervention (Lighting Africa) and a theoretical approach to understanding how such transformations can be achieved in the Global South (socio-technical innovation system, STIS, building). The paper makes four contributions. First, it tests the extent to which the STIS-building concept is useful in understanding and conceptualising how Lighting Africa transformed the market for solar lanterns in Kenya from an estimated market size of 29,000 lamps in 2009 to one where 680,000 Lighting Africa certified lamps were sold in Kenya by the end of the Programme in 2013. Second, it presents the most in-depth analysis of Lighting Africa that we are aware of to date. Third, it presents a conceptual framework that illustrates the Lighting Africa approach, providing a framework for future policy interventions aiming to transform access to clean energy technologies in the Global South. Fourth, it reflects on weaknesses in the STIS approach. In particular, these include a need to better attend to: the gendered implications of interventions (and social justice more broadly); implications of different scales of technologies; value accumulation and the extent to which interventions benefit indigenous actors and local economies; and the political and economic implications of any intervention and its distribution of benefits.
Capillary Desaturation Tendency of Hybrid Engineered Water-Based Chemical Enhanced Oil Recovery Methods
Authors: Shakeel Mariam , Samanova Aida , Pourafshary Peyman , Hashmet Muhammad Rehan
Published: July 2021

Several studies have shown the synergetic benefits of combining various chemical enhanced oil recovery (CEOR) methods with engineered waterflooding (EWF) in both sandstones and carbonate formations. This paper compares the capillary desaturation tendency of various hybrid combinations of engineered water (EW) and CEOR methods with their conventional counterparts. Several coreflood experiments were conducted, including EW-surfactant flooding (EWSF), EW-polymer flooding (EWPF), EW-alkali-surfactant flooding (EWASF), EW-surfactant-polymer flooding (EWSPF), and EW-alkali-surfactant-polymer flooding (EWASP). Capillary numbers (Nc) and corresponding residual oil saturation (Sor) for each scenario are compared with capillary desaturation curves (CDC) of conventional CEOR methods from the literature. The results indicate that hybrid EW–CEOR methods have higher capillary desaturation tendency compared to conventional methods. The capillary numbers obtained by standalone polymer flooding (PF) are usually in the range from 10−6 to 10−5, which are not sufficient to cause a significant reduction in Sor. However, the hybrid EW-polymer flooding approach considerably reduced the Sor for the same Nc values, proving the effectiveness of the investigated method. The hybrid EWASP flooding caused the highest reduction in Sor (23%) against Nc values of 8 × 10−2, while conventional ASP flooding reduced the Sor for relatively higher Nc values (3 × 10−3 to 8 × 10−1). Overall, the hybrid methods are 30–70% more efficient in terms of recovering residual oil, compared to standalone EWF and CEOR methods. This can be attributed to the combination of different mechanisms such as wettability modification by EW, ultralow interfacial tension by alkali and surfactant, reduced surfactant adsorption by alkali addition, and favorable mobility ratio by polymer. Based on the promising results, these hybrid techniques can be effectively implemented to carbonate formations with harsh reservoir conditions such as high salinity and high temperature.
Applicability Study of a Sunken Vessel as an Artificial Reef in a High Wave Energy Zone
Authors: Kim Hyun-Dong , Kim Kyu-Han , Shim Kyu-Tae , Oh Hyumin
Published: July 2021

The purpose of this study is to analyze the applicability of a sunken vessel as an artificial reef in a high wave energy area in a shallow water zone. Artificial reefs in general shapes are unlikely to be installed and maintained stably in high-energy wave zones. To solve this problem, a method for using a large 2000-ton class sunken vessel as an artificial reef was proposed in this study. Accordingly, we analyzed the applicability, including stability, of the sunken vessel as an artificial reef on the east coast of South Korea, where high-energy waves and swells are observed frequently. In the analysis process, various methods, such as numerical simulation and a hydraulic model experiment, were utilized. 2D and 3D numerical simulations were conducted to simulate the wave energy in the area where the sunken vessel was installed as an artificial reef to identify wave force applied to the vessel. Moreover, a hydraulic model experiment using a sunken vessel model as an artificial reef was performed to compare the stability and motion properties of the vessel model. The experimental results indicated that the stability and motion properties of the sunken vessel differed depending on the water depth. Additionally, the water depth that ensured the stability of the sunken vessel was identified.
An Innovative Strategy Allowing a Holistic System Change towards Circular Economy within Supply-Chains
Authors: Mangers Jeff , Minoufekr Meysam , Plapper Peter , Kolla Sri
Published: July 2021

The concept of the circular economy (CE) is receiving encouraging attention among scholars and practitioners, as a convenient solution to move away from the linear economy concept without neglecting the goals of sustainable development. The main goals of the CE are the closing of resource loops and the keeping of resources in the system for as long as possible at the highest utility level. However, as a result of the lack of internationally accepted definitions of the CE and several unsolved barriers, an excessive and inconsistent number of different CE applications exist. Most fields are mainly focusing on making a linear system circular instead of applying the CE principles in a holistic way. This paper presents a strategy to close the mentioned inconsistency gap, by contrasting currently discussed CE barriers and goals and thereof deriving two areas with a need for action (1. identifying the needed collection, sorting, and recovery infrastructure, and 2. developing circular product design guidelines). The strategy itself consists of connecting these two areas through an improved information exchange between the end-of-life (EOL) and beginning-of-life (BOL) of products. The result is CE design guidelines which are in accordance with the available or needed collection, sorting, and recovery infrastructure. The proposed strategy presents an innovative solution to apply CE principles in a holistic manner, based on EOL-driven product design.
Enhancement of Induction Motor Dynamics Using a Novel Sensorless Predictive Control Algorithm
Authors: Echeikh Hamdi , Mossa Mahmoud A. , Quynh Nguyen Vu , Ahmed Abdelsalam A. , Alhelou Hassan Haes
Published: July 2021

The paper introduces a novel predictive voltage control (PVC) procedure for a sensorless induction motor (IM) drive. In the constructed PVC scheme, the direct and quadrature (d-q) components of applied voltages are primarily managed instead of controlling the torque and flux as in the classic predictive torque control (PTC) technique. The theoretical basis of the designed PVC is presented and explained in detail, starting from the used cost-function with its relevant components. A comprehensive performance comparison is established between the two controllers, from which the superiorities of the designed PVC over the PTC approach can be easily investigated through the reduced ripples, reduced computation time, and faster dynamics. To sustain the system’s reliability, a combined Luenberger–sliding mode observer (L-SMO) is designed and verified for different operating speeds for the two controllers. The Luenberger component is concerned with estimating the stator current, rotor flux, and rotor speed. Meanwhile, the sliding mode term is used to ensure the system’s robustness against any disturbance. The verification of PVC’s validity is outlined through performing a performance analysis using the Matlab/Simulink software. The results illustrate that the IM dynamic is significantly improved when considering the constructed PVC compared with the IM dynamics under the PTC. In addition, the designed L-SMO observer has effectively proved its ability to achieve definite parameters and variable estimation.
Robust Multi-Step Predictor for Electricity Markets with Real-Time Pricing
Authors: Kahawala Sachin , De Silva Daswin , Sierla Seppo , Alahakoon Damminda , Nawaratne Rashmika , Osipov Evgeny , Jennings Andrew , Vyatkin Valeriy
Published: July 2021

Real-time electricity pricing mechanisms are emerging as a key component of the smart grid. However, prior work has not fully addressed the challenges of multi-step prediction (Predicting multiple time steps into the future) that is accurate, robust and real-time. This paper proposes a novel Artificial Intelligence-based approach, Robust Intelligent Price Prediction in Real-time (RIPPR), that overcomes these challenges. RIPPR utilizes Variational Mode Decomposition (VMD) to transform the spot price data stream into sub-series that are optimized for robustness using the particle swarm optimization (PSO) algorithm. These sub-series are inputted to a Random Vector Functional Link neural network algorithm for real-time multi-step prediction. A mirror extension removal of VMD, including continuous and discrete spaces in the PSO, is a further novel contribution that improves the effectiveness of RIPPR. The superiority of the proposed RIPPR is demonstrated using three empirical studies of multi-step price prediction of the Australian electricity market.
Growing Poplar in Acid Soils: Biomass Yield and Ash Behavior
Authors: Eimil-Fraga Cristina , Oliveira Nerea , Ortíz-Torres Luis , Rodríguez-Somoza Juan Luis , Rodríguez-Soalleiro Roque
Published: July 2021

Atlantic areas of southern Europe have low water restrictions but are also characterized by acid soils with low intrinsic fertility, so the selection of clones that have adapted to these characteristics is essential. In this study, biomass yield data for eight poplar clones established in two trials were evaluated after the first rotation. Both sites were representative of acid soils that had previously been used for agriculture and had low levels of alkali and alkaline earth elements. The first trial was used to determine which clones performed the best in terms of biomass and stem size, testing two Populus × euramericana (Dode) Guinier (I-214 and AF2), two P. × interamericana Van Brokehuizen × P. nigra L. (Monviso, AF6), three P. × interamericana (Unal, Beaupre and Raspalje), and one P. trichocarpa Torr & A. Gray (Trichobel) clone. The second trial explored the possibility of simultaneously growing biomass and timber, specifically considering the Raspalje and Trichobel balsam poplar clones. To complete a previous study on energy properties, nine biomass samples were obtained from each of the eight clones to evaluate the composition and behavior of the ash generated during combustion, particularly the sintering risk. Several indices of sintering risk were explored and compared with the actual sintering using the BioSlag test. The results show large differences in biomass yield between clones, with the balsam poplar derived clones (both hybrid or pure Populus trichocarpa) performing the best. Growth results for stems planted for wood and the cuttings planted in between these stems show that a mixed biomass–timber arrangement provides good results, at least during the first rotation. The relative proportion of oxides in the poplar ash followed the order CaO > K2O > MgO >> P2O5 >> SiO2 > Al2O3 > Na2O > Fe2O5 >> TiO2. Significant differences between clones were found for K2O and MgO. Risk indices showed moderate levels of sintering derived from alkali elements, with significant differences between clones. The actual slagging and the hardness of the slag particles were very low thus, denoting good ash behavior during combustion, particularly for the clones selected for biomass yield. No significant covariate effect of basal diameter was found for any of the analyzed variables. We conclude that growing site-undemanding poplar clones in acid soils can yield both reasonable levels of biomass yield and good quality chips for combustion in domestic thermal systems.
Exploring the Next Wave of Blockchain and Distributed Ledger Technology: The Overlooked Potential of Scenario Analysis
Authors: Treiblmaier Horst
Published: July 2021

Blockchain is predicted to disrupt industries, economies, and societies. The properties of distributed ledgers allow the creation of immutable data structures that facilitate shared access in real time and enable a plethora of innovative applications. However, blockchain is not a uniform technology but rather a bundle of evolving components whose implications are notoriously hard to predict. At present, it is not clear how current trends will evolve, with technical evolution, legislation, and public policy being three contingency factors that make ongoing disruptive transformations particularly hard to predict. In light of blockchain’s potential disruptive impact, it is surprising that scenario analysis has hitherto been largely ignored in academic research. Therefore, in this paper, we introduce the technique, clarify several misconceptions, and provide examples illustrating how this method can help to overcome the limitations of existing technology impact research. We conclude that if applied correctly, scenario analysis represents the ideal tool to rigorously explore uncertain future developments and to create a comprehensive foundation for future research.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied
Authors: Komaroff Anthony L.
Published: July 2021

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness defined predominantly by symptoms. Routine laboratory test results often are normal, raising the question of whether there are any underlying objective abnormalities. In the past 20 years, however, new research technologies have uncovered a series of biological abnormalities in people with ME/CFS. Unfortunately, many physicians remain unaware of this, and some tell patients that “there is nothing wrong” with them. This skepticism delegitimizes, and thereby multiplies, the patients’ suffering.
How Have Researchers Acknowledged and Controlled for Academic Work Activity When Measuring Medical Students’ Internet Addiction? A Systematic Literature Review
Authors: Masters Ken , Loda Teresa , Tervooren Finja , Herrmann-Werner Anne
Published: July 2021

Internationally, medical students’ Internet Addiction (IA) is widely studied. As medical students use the Internet extensively for work, we asked how researchers control for work-related Internet activity, and the extent to which this influences interpretations of “addiction” rates. A search of PubMed, CINAHL, Web of Science, Scopus, and Google Scholar was conducted on the search phrase of “medical students” and “internet addiction” in March 2020. In total, 98 studies met our criteria, 88 (90%) used Young’s Internet Addiction Test, and the studies’ IA rates ranged widely. Little note was taken of work-related activity, and, when discussed, had little to no impact on the interpretation of Internet “addiction”. Studies seldom accounted for work-related activities, researcher bias appears to influence their position, “usage” appears conflated with “addiction”, and correlations between “addiction” and negative behaviours are frequently confused with one-way causation. In spite of IA’s not being officially recognised, few researchers questioned its validity. While IA may exist among medical students, its measurement is flawed; given the use of the Internet as a crucial medical education tool, there is the risk that conscientious students will be labelled “addicted”, and poor academic performance may be attributed to this “addiction”.
Characterization, Spatial Variation and Management Strategy of Sewer Sediments Collected from Combined Sewer System: A Case Study in Longgang District, Shenzhen
Authors: Luo Yongpeng , Bao Shenxu , Yang Siyuan , Zhang Yimin , Ping Yang , Lin Chao , Yang Pan
Published: July 2021

In the urban drainage system, the formation of sewer sediments is inevitable, and the removal of sewer sediments is necessary for system maintenance. Disposal of arisings from sewer sediment removal is becoming a serious environmental issue. The current knowledge of sewer sediments is limited, which is restrained to sewer sediments management. To better understand this municipal waste, the sewer sediments of a combined sewer system in Longgang District, Shenzhen were collected and characterized, and the spatial distribution characteristics of contaminants were analyzed. Based on the bivariate correlation analysis, it is found that many contaminants in sewer sediments have a strong relationship with spatial variables. Compared to the sewer sediments in industrial areas, those in residential areas contain higher concentrations of Hg and phosphorus. The sediments in the sewage conduit also contain more organic matter (OM), phosphorus, Cu, and Ni, and the sediments in the rainwater conduit contain a higher concentration of Cd. Moreover, the sediments produced in different catchments also show huge differences in the content of contaminants. These spatial distribution characteristics may provide help for the further classification of sewer sediments, thereby making the disposal of sediments more targeted. According to the local standards of sludge disposal, land application and incineration are not suitable for managing sewer sediments due to the low OM content and poor lower heating value (LHV). Although sanitary landfill is feasible for sewer sediments disposal, the complicated composition of sewer sediments still poses the risk of polluting the surrounding environment. The management of sewer sediments via the production of building materials is a promising technical route that can avoid the migration of hazardous contaminants and produce valuable products. This study may improve our understanding of sewer sediments and provide a reliable recommendation for sewer sediment management.
Multidisciplinary Care after Acute Care for Stroke: A Prospective Comparison between a Multidisciplinary Post-Acute Care Group and a Standard Group Matched by Propensity Score
Authors: Chiu Chong-Chi , Lin Hsiu-Fen , Lin Ching-Huang , Chang Hong-Tai , Hsien Hong-Hsi , Hung Kuo-Wei , Tung Sheng-Li , Shi Hon-Yi
Published: July 2021

In this large-scale prospective cohort study, a propensity score matching method was applied in a natural experimental design to investigate how post-acute care (PAC) after stroke affects functional status and to identify predictors of functional status. The main objective of this study was to examine longitudinal changes in various measures of functional status in stroke patients and predictors of scores for these measures before and after PAC. A group of patients who had received PAC for stroke at one of two medical centers (PAC group, n = 273) was compared with a group who had received standard care for stroke at one of four hospitals (three regional hospital and one district hospital; non-PAC group, n = 273) in Taiwan from March, 2014, to October, 2018. The patients completed the functional status measures before rehabilitation, the 12th week and the 1st year after rehabilitation. Generalized estimating equations were used to estimate differences-in-differences models for examining the effects of PAC. The average age was 68.0 (SD = 8.1) years, and males accounted for 57.9%. During the follow-up period, significant risk factors for poor functional outcomes were advanced age, hemorrhagic stroke, and poor function scores before rehabilitation (p < 0.05). Between-group comparisons at subsequent time points revealed significantly higher functional status scores in the PAC group versus the non-PAC group (p < 0.001). Notably, for all functional status measures, between-group differences in total scores significantly increased over time from baseline to 1 year post-rehabilitation (p < 0.001). The contribution of this study is its further elucidation of the clinical implications and health policy implications of rehabilitative care after stroke. Specifically, it improves understanding of the effects of PAC in stroke patients at different follow-up times. Therefore, a policy implication of this study is that standard care for stroke should include intensive rehabilitative PAC to maximize recovery of overall function.
The Relationship between Family Functioning and Pathological Internet Use among Chinese Adolescents: The Mediating Role of Hope and the Moderating Role of Social Withdrawal
Authors: Li Xing-Kai , Zhan Pei-Shan , Chen Shu-Dan , Ren Jie
Published: July 2021

This study constructed a moderated mediation model based on problem behavior theory to explore the psychological mechanism of family functioning interaction with pathological internet use. We used the Adolescent Pathological Internet Use Scale, General Functioning Scale, Trait Hope Scale, and Social Withdrawal Scale to measure internet use in 1223 middle school students. The results showed that (1) pathological internet use was negatively correlated with family functioning and hope, and positively correlated with social withdrawal; family functioning was positively correlated with hope, and negatively correlated with social withdrawal; hope was negatively correlated with social withdrawal; (2) family functioning could not only directly predict pathological internet use, but also indirectly predict pathological internet use through hope; and (3) the mediating effect of family functioning on pathological internet use was moderated by social withdrawal, which was stronger for individuals with low social withdrawal but not significant for individuals with high social withdrawal. This study revealed the internal mechanism of the relation between family functioning and adolescents’ pathological internet use, which has theoretical significance for improving adolescents’ hope and reducing their pathological internet use.
Outdoor Recreation for Older Adults in Scotland: Qualitatively Exploring the Multiplicity of Constraints to Participation
Authors: Currie Margaret , Colley Kathryn , Irvine Katherine N.
Published: July 2021

Active ageing can lead to better health outcomes in older people. Examining constraints to outdoor recreation for older people, including outdoor physical activity, may therefore assist with developing strategies for active ageing. Findings are presented from a study seeking to understand the constraints to older peoples’ access to outdoor recreation in Scotland, and this paper aimed to examine the multitude of constraints that discourage or prevent older people from accessing the outdoors and the ways in which these constraints are hierarchical (or not). This paper adopted a qualitative methodology using the hierarchical leisure constraints model (HLCM) as a lens to analyse the data, presenting the data in three vignettes. The paper identified multiple co-occurring constraints and considered these in relation to expectations based on the HLCM. Recognising that constraints to outdoor recreation for older people are multiple, co-occurring and mutually reinforcing may enable more effective solutions to be developed to overcome them.
Functioning and Happiness in People with Schizophrenia: Analyzing the Role of Cognitive Impairment
Authors: Gutiérrez-Rojas Luis , González-Domenech Pablo Jose , Junquera Gema , Halverson Tate F. , Lahera Guillermo
Published: July 2021

Schizophrenia is associated with marked functional impairment and low levels of subjective happiness. The aim of the current study was to evaluate the relationship between subjective happiness and functioning in patients with schizophrenia, while considering the role of cognitive functioning. Methods: In total, 69 schizophrenia patients and 87 matched healthy controls participated in the study. Patients’ clinical status was assessed, and a series of self-report questionnaires were administered to both patients and healthy controls to measure subjective happiness, satisfaction with life, well-being, functioning, and cognitive impairment. A multiple linear regression model identified significant predictors of subjective happiness and related constructs. Results: Schizophrenia participants endorsed lower levels of happiness and well-being, and higher perceived stress compared to healthy controls. In schizophrenia patients, there was an inverse and significant correlation (r = −0.435; p = 0.013) between subjective happiness and functioning in a subgroup of patients without cognitive impairment. This correlation was not significant (r = −0.175; p = 0.300) in the subgroup with cognitive impairment. When controlling for other clinical variables (by multiple lineal regression), the severity of symptoms and level of insight failed to demonstrate significant relationships with happiness; meanwhile, perceived stress and some specific cognitive dominions (as verbal learning and processing speed) were associated with satisfaction of life of the patients. Conclusions: The relationship between subjective happiness and functioning in schizophrenia patients was influenced by level of cognitive impairment. Findings from this study suggest that rehabilitation programs may improve recovery outcomes with a focus on subjective happiness and functioning, especially in patients with cognitive impairment. Future research is needed to better understand the complex interplay between subjective happiness, functioning, and cognitive impairment in patients with schizophrenia.
Effects of Group and Individual Culturally Adapted Cognitive Behavioral Therapy on Depression and Sexual Satisfaction among Perimenopausal Women
Authors: Khoshbooii Robab , Hassan Siti Aishah , Deylami Neda , Muhamad Rosediani , Engku Kamarudin Engku Mardiah , Alareqe Naser Abdulhafeeth
Published: July 2021

Aims: Previous research has shown the efficacy of culturally adapted Cognitive Behavioral Therapy (CA-CBT) in reducing depression, yet its effect on increasing sexual satisfaction is not well documented. In this study, an embedded randomized controlled trial design was used to examine the effect of group and individual CA-CBT on depression and sexual satisfaction among perimenopausal women. Method: A total of 64 depressed Iranian perimenopausal women were randomly assigned to two formats of treatments; sixteen sessions of group CA-CBT and eight sessions of individual CA-CBT, as well as a waitlist control group. Depression and sexual satisfaction were measured using BDI-II and ENRICH, respectively, at T1 (pre-treatment), T2 (post-treatment) and T3 (follow-up). Results: Repeated measures ANOVA indicated that the women who underwent both group and individual CA-CBT had effectively reduced depression and increased sexual satisfaction between pre-treatment and post-treatment, and it was sustained after six months of follow-ups with large effect sizes of significant differences (p < 0.001), but the control group did not. Conclusion: The results showed promising evidence for the efficacy of both treatment groups of CA-CBT for depression and sexual satisfaction among perimenopausal women. The population mental health burden among perimenopausal women may likely be reduced by propagating this effective treatment.
The Influence of Signals on Donation Crowdfunding Campaign Success during COVID-19 Crisis
Authors: Ho Han-Chiang , Chiu Candy Lim , Mansumitrchai Somkiat , Yuan Zhengqing , Zhao Nan , Zou Jiajie
Published: July 2021

In 2020, the coronavirus pandemic devasted public health agencies and the federal government across the world. Bridging the gap between underserved populations and the healthcare system, the donation-based crowdfunding campaign has opened a new way for suffering individuals and families to access broader social network platforms for financial and non-financial assistance. Despite the growing popularity of crowdfunding during the pandemic crisis, little research has explored the various signals that attract potential donors to donate. This study explores the effects of signaling theory on the success of a crowdfunding campaign for food relief launched in GoFundMe during which the United States was severely affected by the pandemic with a surged number of coronavirus infected cases from 1 March with 134 confirmed COVID-19 infected cases to 29 July with 4,295,308 infected cases according to World Health Organization. The following results show that the three different signal success measures are important to the success of crowdfunding campaigns: (1) signals originating from the campaign (Title, Description, Spelling Error, Location, and Picture); (2) signals originating from the fundraiser (Social Network, and Update); and (3) signals originating from the social interaction of the fundraiser with the crowd (Comment, Follower, and Share). These findings provide insight and bring additional knowledge contribution to the crowdfunding literature.
Cardiomyopathies: An Overview
Authors: Ciarambino Tiziana , Menna Giovanni , Sansone Gennaro , Giordano Mauro
Published: July 2021

Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by structural and functional alterations of the heart. Aims: The purpose of this narrative review is to focus on the most important cardiomyopathies and their epidemiology, diagnosis, and management. Methods: Clinical trials were identified by Pubmed until 30 March 2021. The search keywords were “cardiomyopathies, sudden cardiac arrest, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy, arrhythmogenic cardiomyopathy (ARCV), takotsubo syndrome”. Results: Hypertrophic cardiomyopathy (HCM) is the most common primary cardiomyopathy, with a prevalence of 1:500 persons. Dilated cardiomyopathy (DCM) has a prevalence of 1:2500 and is the leading indication for heart transplantation. Restrictive cardiomyopathy (RCM) is the least common of the major cardiomyopathies, representing 2% to 5% of cases. Arrhythmogenic cardiomyopathy (ARCV) is a pathology characterized by the substitution of the myocardium by fibrofatty tissue. Takotsubo cardiomyopathy is defined as an abrupt onset of left ventricular dysfunction in response to severe emotional or physiologic stress. Conclusion: In particular, it has been reported that HCM is the most important cause of sudden death on the athletic field in the United States. It is needless to say how important it is to know which changes in the heart due to physical activity are normal, and when they are pathological.
Carbon-Based Nanomaterials
Authors: Díez-Pascual Ana María
Published: July 2021

Research on carbon-based nanomaterials, such as carbon nanotubes, graphene and its derivatives, nanodiamonds, fullerenes, and other nanosized carbon allotropes, has experienced sharp exponential growth over recent years [...]
Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
Authors: Szwedowicz Urszula , Szewczyk Anna , Gołąb Krzysztof , Choromańska Anna
Published: July 2021

Despite a wide range of bactericides and antiseptics, the treatment of chronic or complicated wounds is still a major challenge for modern medicine. Topical medications are the most sought-after new agents for use as treatment. The therapeutic concentration of their active substances is easy to achieve with the lowest possible burden on the patient’s body. This study assesses the effect of salvianolic acid B (Sal B) on the proliferation, migration, and production of collagen type III by fibroblasts, which are the most important processes in wound healing. The study was conducted on human gingival fibroblasts obtained from primary cell culture. The results showed that Sal B at a dose of 75 µg/mL increases the cell viability with significant stimulation of the cell migration as demonstrated in the wound healing assay, as well as an increase in the expression of collagen type III, which has great importance in the initial stages of wound scarring. The results obtained in the conducted studies and previous scientific reports on the antibacterial properties and low toxicity of Sal B indicate its high potential in wound healing.
Genome-Wide Identification of GRAS Gene Family and Their Responses to Abiotic Stress in Medicago sativa
Authors: Zhang Han , Liu Xiqiang , Wang Xuemeng , Sun Ming , Song Rui , Mao Peisheng , Jia Shangang
Published: July 2021

Alfalfa (Medicago sativa) is a high-quality legume forage crop worldwide, and alfalfa production is often threatened by abiotic environmental stresses. GRAS proteins are important transcription factors that play a vital role in plant development, as well as in response to environmental stress. In this study, the availability of alfalfa genome “Zhongmu No.1” allowed us to identify 51 GRAS family members, i.e., MsGRAS. MsGRAS proteins could be classified into nine subgroups with distinct conserved domains, and tandem and segmental duplications were observed as an expansion strategy of this gene family. In RNA-Seq analysis, 14 MsGRAS genes were not expressed in the leaf or root, 6 GRAS genes in 3 differentially expressed gene clusters were involved in the salinity stress response in the leaf. Moreover, qRT-PCR results confirmed that MsGRAS51 expression was induced under drought stress and hormone treatments (ABA, GA and IAA) but down-regulated in salinity stress. Collectively, our genome-wide characterization, evolutionary, and expression analysis suggested that the MsGRAS proteins might play crucial roles in response to abiotic stresses and hormonal cues in alfalfa. For the breeding of alfalfa, it provided important information on stress resistance and functional studies on MsGRAS and hormone signaling.
Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors
Authors: Reiberger Robert , Radilová Kateřina , Kráľ Michal , Zima Václav , Majer Pavel , Brynda Jiří , Dračínský Martin , Konvalinka Jan , Kožíšek Milan , Machara Aleš
Published: July 2021

The part of the influenza polymerase PA subunit featuring endonuclease activity is a target for anti-influenza therapies, including the FDA-approved drug Xofluza. A general feature of endonuclease inhibitors is their ability to chelate Mg2+ or Mn2+ ions located in the enzyme’s catalytic site. Previously, we screened a panel of flavonoids for PA inhibition and found luteolin and its C-glucoside orientin to be potent inhibitors. Through structural analysis, we identified the presence of a 3′,4′-dihydroxyphenyl moiety as a crucial feature for sub-micromolar inhibitory activity. Here, we report results from a subsequent investigation exploring structural changes at the C-7 and C-8 positions of luteolin. Experimental IC50 values were determined by AlphaScreen technology. The most potent inhibitors were C-8 derivatives with inhibitory potencies comparable to that of luteolin. Bio-isosteric replacement of the C-7 hydroxyl moiety of luteolin led to a series of compounds with one-order-of-magnitude-lower inhibitory potencies. Using X-ray crystallography, we solved structures of the wild-type PA-N-terminal domain and its I38T mutant in complex with orientin at 1.9 Å and 2.2 Å resolution, respectively.
A Bioglass-Based Antibiotic (Vancomycin) Releasing Bone Void Filling Putty to Treat Osteomyelitis and Aid Bone Healing
Authors: Hasan Raquib , Schaner Kambri , Mulinti Pranothi , Brooks Amanda
Published: July 2021

While the infection rate after primary total joint replacements (TJR) sits at 1–2%, for trauma-related surgery, it can be as high as 3.6 to 21.2% based on the type of trauma; the risk of reinfection after revision surgery is even higher. Current treatments with antibiotic-releasing PMMA-based bone cement/ beads and/or systemic antibiotic after surgical debridement do not provide effective treatment due to fluctuating antibiotic levels at the site of infection, leading to insufficient local antibiotic concentration. In addition, non-biodegradable PMMA does not support bone regrowth in the debrided void spaces and often must be removed in an additional surgery. Here, we report a bioactive glass or bioglass (BG) substrate-based biodegradable, easy to fabricate “press fitting” antibiotic-releasing bone void filling (ABVF-BG) putty to provide effective local antibiotic release at the site of infection along with support for bone regeneration. The ABVF-BG putty formulation had homogenously distributed BG particles, a porous structure, and showed putty-like ease of handling. Furthermore, the ABVF-BG putty demonstrated in vitro antibacterial activity for up to 6 weeks. Finally, the ABVF-BG putty was biodegradable in vivo and showed 100% bacterial eradication (as shown by bacterial cell counts) in the treatment group, which received ABVF-BG putty, compared to the infection control group, where all the rats had a high bacterial load (4.63 × 106 ± 7.9 × 105 CFU/gram bone) and sustained osteomyelitis. The ABVF-BG putty also supported bone growth in the void space as indicated by a combination of histology, µCT, and X-ray imaging. The potential for simultaneous infection treatment and bone healing using the developed BG-based ABVF-BG putty is promising as an alternative treatment option for osteomyelitis.
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Authors: Kerem Liya , Lawson Elizabeth A.
Published: July 2021

The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological processes, including parturition, lactation, cell growth, wound healing, and social behavior. More recently, increasing evidence has established the effects of oxytocin on food intake, energy expenditure, and peripheral metabolism. In this review, we provide a comprehensive description of the central oxytocinergic system in which oxytocin acts to shape eating behavior and metabolism. Next, we discuss the peripheral beneficial effects oxytocin exerts on key metabolic organs, including suppression of visceral adipose tissue inflammation, skeletal muscle regeneration, and bone tissue mineralization. A brief summary of oxytocin actions learned from animal models is presented, showing that weight loss induced by chronic oxytocin treatment is related not only to its anorexigenic effects, but also to the resulting increase in energy expenditure and lipolysis. Following an in-depth discussion on the technical challenges related to endogenous oxytocin measurements in humans, we synthesize data related to the association between endogenous oxytocin levels, weight status, metabolic syndrome, and bone health. We then review clinical trials showing that in humans, acute oxytocin administration reduces food intake, attenuates fMRI activation of food motivation brain areas, and increases activation of self-control brain regions. Further strengthening the role of oxytocin in appetite regulation, we review conditions of hypothalamic insult and certain genetic pathologies associated with oxytocin depletion that present with hyperphagia, extreme weight gain, and poor metabolic profile. Intranasal oxytocin is currently being evaluated in human clinical trials to learn whether oxytocin-based therapeutics can be used to treat obesity and its associated sequela. At the end of this review, we address the fundamental challenges that remain in translating this line of research to clinical care.
Biological In Vitro Evaluation of PIL Graft Conjugates: Cytotoxicity Characteristics
Authors: Niesyto Katarzyna , Łyżniak Wiktoria , Skonieczna Magdalena , Neugebauer Dorota
Published: July 2021

In vitro cytotoxicity of polymer-carriers, which in the side chains contain the cholinum ionic liquid units with chloride (Cl) or pharmaceutical anions dedicated for antituberculosis therapy, i.e., p-aminosalicylate (PAS) and clavulanate (CLV), was investigated. The carriers and drug conjugates were examined, in the concentration range of 3.125–100 μg/mL, against human bronchial epithelial cells (BEAS-2B) and adenocarcinomic human alveolar basal epithelial cells (A549) as an experimental model cancer cell line possibly coexisting in tuberculosis. The cytotoxicity was evaluated by MTT test and confluency index, as well as by the cytometric analyses, including Annexin-V FITC apoptosis assay. The polymer systems showed supporting activity towards the normal cells and no tumor progress, especially at the highest concentration (100 μg/mL). The analysis of cell death did not show meaningful changes in the case of the BEAS-2B, whereas in the A549 cell line, the cytostatic activity was observed, especially for the drug-free carriers, causing death in up to 80% of cells. This can be regulated by the polymer structure, including the content of cationic units, side-chain length and density, as well as the type and content of pharmaceutical anions. The results of MTT tests, confluency, as well as cytometric analyses, distinguished the polymer systems with Cl/PAS/CLV containing 26% of grafting degree and 43% of ionic units or 46% of grafting degree and 18% of ionic units as the optimal systems.
6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish
Authors: Gawel Kinga , Kukula-Koch Wirginia , Banono Nancy Saana , Nieoczym Dorota , Targowska-Duda Katarzyna M. , Czernicka Lidia , Parada-Turska Jolanta , Esguerra Camila V.
Published: July 2021

Zingiber officinale is one of the most frequently used medicinal herbs in Asia. Using rodent seizure models, it was previously shown that Zingiber officinale hydroethanolic extract exerts antiseizure activity, but the active constituents responsible for this effect have not been determined. In this paper, we demonstrated that Zingiber officinale methanolic extract exerts anticonvulsant activity in the pentylenetetrazole (PTZ)-induced hyperlocomotion assay in larval zebrafish. Next, we isolated 6-gingerol (6-GIN)—a major constituent of Zingiber officinale rhizoma. We observed that 6-GIN exerted potent dose-dependent anticonvulsant activity in the PTZ-induced hyperlocomotion seizure assay in zebrafish, which was confirmed electroencephalographically. To obtain further insight into the molecular mechanisms of 6-GIN antiseizure activity, we assessed the concentration of two neurotransmitters in zebrafish, i.e., inhibitory γ-aminobutyric acid (GABA) and excitatory glutamic acid (GLU), and their ratio after exposure to acute PTZ dose. Here, 6-GIN decreased GLU level and reduced the GLU/GABA ratio in PTZ-treated fish compared with only PTZ-bathed fish. This activity was associated with the decrease in grin2b, but not gabra1a, grin1a, gria1a, gria2a, and gria3b expression in PTZ-treated fish. Molecular docking to the human NR2B-containing N-methyl-D-aspartate (NMDA) receptor suggests that 6-GIN might act as an inhibitor and interact with the amino terminal domain, the glutamate-binding site, as well as within the ion channel of the NR2B-containing NMDA receptor. In summary, our study reveals, for the first time, the anticonvulsant activity of 6-GIN. We suggest that this effect might at least be partially mediated by restoring the balance between GABA and GLU in the epileptic brain; however, more studies are needed to prove our hypothesis.