bluuebunny/crossref_metadata_2025 huggingface dataset:
A Poikilía e suas presenças na História Natural de Plínio, o Velho
Authors: Martins Ana Carolina Aquarolli , Martins Paulo
Published: December 2024

Este artigo investiga, a partir do conceito de poikilía, ou variedade, como as artes, principal tema dos livros 34, 35 e 36 da História Natural de Plínio, o Velho, relacionam-se com o estilo retórico adotado pelo autor, ou seja, de que maneira se articulam forma e matéria na obra. Exploramos, especificamente, dois aspectos ligados a essa diversidade, a saber, a variedade enquanto uma das características atribuídas a objetos ou técnicas artísticas bem como aos próprios materiais empregados na execução de tais objetos e a variedade no que diz respeito aos recursos retóricos empregados ao longo dos livros. Para tanto, retomaremos a definição de poikilía nas artes e na poesia e veremos de que forma a noção de variegação se aplica à retórica, fazendo-se presente, por fim, na História Natural.
Diálogo com as memórias dos trabalhadores rurais em Araruna - PR
Authors: Souza Gabriel Henrique de , França Cyntia Simioni
Published: December 2024

Este artigo dialoga com as memórias dos trabalhadores rurais de Araruna-PR, destacando suas experiências muitas vezes negligenciadas pela história local. Exploramos como a história de Araruna poderia ser contada a partir dos costumes culturais dos trabalhadores rurais e procuramos compreender seus saberes e práticas socioculturais. Dialogando com o historiador Edward Palmer Thompson (1981), exploramos conceitos como cultura, história, experiência e modos de produção de conhecimento histórico. Também discutimos a perspectiva do geógrafo humanista Yi-Fu Tuan (1983) sobre o rural como espaço para os trabalhadores. A pesquisa envolveu sete famílias, utilizando o referencial teórico-metodológico de Walter Benjamin para práticas de rememoração. Realizamos quatro rodas de conversa, denominadas "cultivos", gravadas e transcritas com a técnica da História Oral. As memórias dos trabalhadores rurais foram organizadas em mônadas benjaminiana, aporte benjaminiano e, depois, organizadas em um site disponibilizado na internet. A pesquisa ainda resultou em um livro que foi disseminado e distribuídos para as escolas da região.
Trauma social y vida cotidiana de familias obreras azucareras antes y después del terrorismo de Estado en Argentina
Authors: Nassif Silvia Gabriela
Published: December 2024

En este artículo se examina la transformación de la vida cotidiana de familias azucareras del noroeste argentino durante el terrorismo de Estado en Argentina. El análisis abarca diversos ámbitos: los hogares, los lugares de trabajo, la comunidad y las organizaciones sindicales. Asimismo, se estudian las huellas dejadas por el proceso represivo en las subjetividades, junto con los procesos, tanto individuales como colectivos, que facilitan la elaboración de estos traumas. Para llevar a cabo este estudio, se emplean herramientas teóricas y metodológicas provistas por la historia oral, la historia social, y la psicología social, en el análisis de testimonios de extrabajadores azucareros en la provincia de Tucumán.
Employees’ Internal Factors Leading to Rule-breaking Acts at the Workplace
Authors: Ikhwanuddin Rizky Yuli , Djunaidi Zulkifli
Published: December 2024

Introduction: The 2022 National Occupational Health and Safety (OHS) Profile in Indonesia shows that the human factor in safety is a factor that influences the risk of workplace accidents. The mining accidents statistical data in Indonesia, in which there was a 100% increase of workplace accidents in 2022, have given this industry an urgency to get a special attention to study risk-taking behavior at the workplace. At the organizational level, PT. XYZ (a mining contractor company in Indonesia) has internally measured its safety maturity level and is currently in calculative level, which indicates that the OHS management system has been implemented but the number of unsafe behaviors and unsafe conditions on site is still high. This paper explores quantitative results from research which aims to obtain an overview of employees’ internal factors leading to rule-breaking acts at the workplace. Methods: This paper uses cross-sectional design research with quantitative approach. Using stratified random sampling, a sample of 283 employees of PT. XYZ Site A participated in this study, ranging from managers, supervisors, and workers. Data were collected through a questionnaire with open-ended questions referring to a study from Safe Work Australia and analyzed quantitatively using statistical Chi-Square statistical test. Results: From the results of the Chi-Square test, the independent variables that have a value of Asymp. Sig. (2-sided) below 0.05 (95% CI) and lead to rule-breaking act at workplace are risk-taking behavior acceptance (0.018), normalizing minor accidents (0.002), and decision to take risk (0.000). Conclusion: Employees’ internal factors of risk-taking behavior acceptance, normalizing minor accidents, and decision to take risk have positive and significant effect on rule-breaking acts at the workplace. It is recommended that organizations implement a proper risk management with ALARP principle, safety empowering leadership, and safe behavior trainings to minimize rule-breaking acts at the workplace
Urgensi Pembentukan Daerah Pemilihan Khusus Luar Negeri dalam Pemilihan Umum Anggota Dewan Perwakilan Rakyat
Authors: Mourita Eghilia Heavy
Published: December 2024

Sejak penyelenggaraan pemilu tahun 1955, undang-undang pemilu Indonesia menetapkan dapil ibukota sebagai konstituensi bagi pemilih di luar negeri. Putusan MK No.2/PUU/XI/2013 menolak tuntutan WNI di luar negeri untuk membentuk dapil khusus luar negeri. Walaupun begitu, isu ini terus digencarkan dalam pembahasan RUU Pemilu Tahun 2017 hingga Pemilu 2019. Sehingga, dapil khusus ini masih belum direalisasikan. Maka, tulisan ini bertujuan untuk menganalisa landasan konstitusional pembentukan dapil khusus luar negeri dalam pemilu anggota DPR dan model pembentukan dapil khusus luar negeri dalam sistem pemilu anggota DPR. Tulisan ini merupakan penelitian hukum normatif yang menekankan pada pendekatan peraturan perundang-undangan, komparatif, kasus, dan konseptual. Hasil penelitian ini menyatakan bahwa legalitas pembentukan dapil khusus luar negeri adalah Pasal 22E ayat (6) UUD NRI Tahun 1945 yang mencerminkan prinsip kebijakan hukum terbuka. Model dapil khusus luar negeri dengan cakupan wilayah regional/gabungan wilayah regional dianggap paling cocok untuk diterapkan dalam pemilu anggota DPR.
Safety Climate and Safety Leadership Influence on Safety Performance in East Kalimantan Heavy Equipment Employees
Authors: Puspitarini Made Yenny , Martiana Tri
Published: December 2024

Background: Maintaining and repairing heavy machinery in coal mines included significant danger and may result in mishaps. Even with management's best efforts to provide acceptable employment, policies, practices, infrastructure, and safety gear, property damage and small injury occurrences nevertheless happen.
Objective: Examine how safety leadership and the safety environment affect employees of East Kalimantan heavy equipment companies' performance in terms of safety.
Method: A questionnaire was utilized in the study to gather data from 65 respondents who were chosen by simple random selection.
Results: The safety climate is positively and significantly impacted by safety leadership, according to path analysis (path coef = 0.962). Safety performance is positively and significantly impacted by safety leadership and climate (path coef = 0.562 and 0.415, respectively). With safety climate acting as a mediator, safety leadership may influence safety performance (path coef= 0.3992).
Conclusion:  Safety leadership and safety climate can be antecedents for the safety performance of East Kalimantan heavy equipment company employees. Companies need to strengthen safety leadership by ensuring leaders practice safety principles, as well as creating a safety climate that is conducive to increasing employee safety commitment.
The Descriptive Epidemiology of Tuberculosis in the City of Surabaya from 2018 to 2022
Authors: Rahmahdia Asti Alya , Sari Siti Shofiya Novita , Astutik Erni
Published: December 2024

Background: Tuberculosis (TB) remains a top-ranking communicable disease in terms of morbidity and mortality factors in Indonesia. Surabaya city has the highest TB cases in East Java in 2022, with a prevalence rate of 355 per 100,000 population.
Objectives: This study will provide an overview of tuberculosis cases in Surabaya City from 2018 to 2022.
Methods: The research employs a descriptive approach using an ecological study design. The aggregate data sourced from the Surabaya City Health Office's reports, with the analysis unit being the sub-district, are utilized in this study. Other articles serve as comparative sources for the findings in this research.
Results: Throughout the years 2018 to 2022, the spread of TB was higher in males than females, with a prevalence exceeding 53%. Based on regions, the prevalence of TB varies across different areas and does not always correlate with regions with high population and density. In terms of time, there was an increase in TB cases before and after the COVID-19 pandemic which is in 2021, there were 4,628 TB cases, which then rose to 8,218 cases in 2022.
Conclusion: TB cases burden in Surabaya City among males during 2018-2022 surpassed females, attributed partly to lifestyle choices and smoking, while population density isn't always the primary factor in TB prevalence due to its multifactorial nature; moreover, the resurgence of TB cases post-pandemic doesn't necessarily signify negativity, as it might indicate improved TB case reporting compared to the COVID-19 pandemic period.
The methods of decreasing FP in Anomaly based Intrusion Prevent System by using of complex information about information system
Authors: Kudin Anton , Grigorieva Olga , Nosok Svitlana
Published: December 2024

The main aim of this work is to optimize the efficiency of intrusion detection using complex analysis of indicators in information system by reducing the number of false positives, as well as the development of a universal technique for such optimization. Using laboratory environment with installed SIEMs Wazuh and Splunk we test the proposed optimization methods and proposed newly methodic for decreasing rating false/positive for some intrusion detecting systems.
Toffoli gate implementation method based on Margolus gate on four or more qubits
Authors: Tereshchenko Andrii , Zadiraka Valeriy
Published: December 2024

This paper considers the method of building the Toffoli Gate based on the Margolus Gate on four or more qubits. In the first part of the considered method, the modification of the Margolus gate on four or more qubits is suggested. In the second part of the method, the modification of the Margolus gate is transformed into the modification of the Toffoli gate implementation using step-by-step phase rotation compensations. The phase rotation compensation for an N-qubit quantum circuit can be performed with N successive steps, where at each step the gates with phase rotation pi/2^(s-1) are added, where s is the step number, starting from one. The compensation phase requires 2 two-qubit gates and 2N-1 one-qubit gates.
Supplementary Currencies: Theory and Practice
Authors: Semeko G.
Published: December 2024

The global financial and economic crisis of late 2000-ies cast a discredit on many official economic science principles. The fundamentally new approach is needed not only to lower the frequency of crises emegring, but also to shut out their recurrence. The currency diversification concept has a real potential and development prospects. Supplementary currencies turned out to be much more stable than national currencies and Euro, because they circulate at a local level only, and cannot become an object of speculation on the global financial market. Such currencies are constantly circulating, enhancing a commercial exchange and allowing people to earn real money. Many supplementary currencies projects are relatively cost-friendly, but proved to be a rather effective instrument of the local ecomomy support and revival, as well as of the social solidarity, cooperation and environmental protection strengthening at a local level.
STUDY OF THE DYNAMICS OF TRUCK MOVEMENT ACROSS A BRIDGE CROSSING
Authors: SLAVINSKA Olena , RAZBOINIKOV Oleksandr , KOZARCHUK Ihor , BUBELA Andriy , IVANUSHKO Oleksandr , KLOCHAN Arsen
Published: December 2024

This paper is the first comprehensive study of the dynamics of truck movement across a bridge crossing with defects on a road surface. A mathematical model of the dynamics of the truck movement across the bridge crossing is obtained. To confirm the adequacy of the proposed mathematical model, a comparative analysis of the results of theoretical and experimental studies was carried out. This approach makes it possible to determine the nature of the distribution of dynamic loads in areas where truck wheels contact with the road surface of the bridge crossing. This research was carried out within the framework of the project “Development of a load model based on the actual parameters of heavy rolling stock to determine the carrying capacity of road bridges during their restoration and operation in the war and post-war periods” under the competition “Science for the Reconstruction of Ukraine in the War and Post-War Periods” at the expense of grant support from the National Research Foundation of Ukraine.
PERFIL EPIDEMIOLÓGICO DA COBERTURA VACINAL EM CRIANÇAS MENORES DE UM ANO EM PALMAS-TOCANTINS NOS ANOS DE 2020 E 2021
Authors: Da Silva Monteiro Ester , Fernandes do Carmo Lemos Fernanda Maria , Rodrigues Evangelista Silva Camilla
Published: December 2024

A vacinação é uma das intervenções de maior custo-efetividade e de considerável impacto na ocorrência de doenças. Logo, é necessário o monitoramento da cobertura vacinal e o perfil vacinal das crianças imunizadas. Objetivou-se conhecer o perfil epidemiológico da cobertura vacinal de crianças de 0 a 12 meses com esquema completo no município de Palmas-TO nos anos de 2020 e 2021. Trata-se de um estudo epidemiológico descritivo, retrospectivo, de abordagem quantitativa que utilizou fonte de dados secundários, provenientes do sistema BI-eSUS e base de dados do Departamento de Informática do SUS. Foi avaliada a cobertura vacinal dos imunobiológicos estabelecidos no primeiro ano de vida e as variáveis selecionadas foram: sexo do familiar, faixa etária, etnia/cor, ocupação e nível de escolaridade do responsável, localização urbana ou rural e renda familiar. Como resultado, a vacina BCG foi a única que apresentou cobertura vacinal superior a 95%, já os demais imunobiológicos não alcançaram a cobertura vacinal preconizada. Referente ao perfil demográfico, destaca-se o ensino médio completo, a renda familiar entre um e dois salários mínimos, sexo feminino e a faixa etária 30 a 39 anos. Logo, melhores padrões sociodemográficos podem contribuir positivamente na adesão à vacinação.
PALAVRAS-CHAVE: Cobertura Vacinal. Saúde da Criança. Vacinação.
Analisis Multi Peran Ibu Rumah Tangga di Desa Slogoretno Kecamatan Jatipurno Kabupaten Wonogiri
Authors: Lestari Ika Puji , Lestari Eny , Setyowati Retno
Published: December 2024

Housewives who participate as workers will experience multiple roles in their lives. The involvement of women in the workforce has the consequence of limiting time in work and family life. Understanding the balance of roles is essential because it can give rise to positive and negative impacts from these multiple roles. This research aims to describe and analyze the roles of housewives and gender relations in the family. This research method is descriptive qualitative with a case study approach. The process for determining informants was carried out purposively with the criteria of coming from a complete farming family (husband and wife) and the wife taking part in instant herbal medicine processing so that 22 informants consisting of the Slogoretno Village Head (1 person), a housewife and her husband (10 pairs), chairman of the family welfare empowerment (PKK) of Slogoretno Village (1 person). Data collection techniques include in-depth interviews, observation, and documentation, employing Miles and Huberman’s interactive analysis and Harvard gender analysis methodologies. Data validity uses triangulation of sources and methods. The results obtained in this research are that the multi-role forms carried out by housewives, especially in farming families, are divided into 7 roles, namely the roles of mother, wife, worker, relative, and roles in domestic, community, and individual activities. The gender dynamics established often involve patterns of cooperation in role division and decision-making, affecting access, control, and benefits related to resources. In Slogoretno Village, the division of roles within farming families reveals that wives and husbands primarily handle reproductive tasks, while productive and social roles are typically shared.
La recepción e influencia del pensamiento de Platón. Un sendero hasta Otloh de San Emeramo, s. XI
Authors: Violante Susana
Published: December 2024

Otloh de San Emeramo (Regensburg 1010-1070) accede al pensamiento de Platón a través de los escritos de los (neo)platónicos. Lee a los pitagóricos, a poetas romanos como Virgilio, Horacio, Lucano, Terencio, Juvenal, Fedro, Marciano Capella y, sobre todo, fue admirador y estudioso de Pseudo-Dionisio Areopagita –pretendió trasladar sus restos a San Emeramo, porque allí habría predicado–, a quien aborda a través de la traducción que realizara Juan Escoto Eriúgena. Estos pensadores le permiten distinguir el sentido “móvil” de la dialéctica, en tanto ejercicio de ascenso y descenso al ámbito inteligible para comprender el sensible. Aplica la dialéctica como un arte para aproximarse a la verdad cuyo movimiento veremos ejemplificado en el encadenamiento de razonamientos, el análisis de sus contradicciones y el intento de su refutación para dilucidarlas y aceptar la duda como algo humano, de lo que no se puede escapar.
Por ello compartimos fragmentos e interpretaciones en las que se vislumbra que las “ideas” tienen diferentes status ontológicos, motivo por el cual sus argumentaciones revisten el carácter de posible, accesible, opinable, aproximado, sin alcanzar la verdad absoluta.
ENFOQUE REGIONALIZADO. LA CASUÍSTICA EN EL MAR BALEAR
Authors: Salas Serra Sebastià , Bonnín Bautista Domingo
Published: December 2024

Regionalization is a general principle of the European Union’s Common Fisheries Policy. This study aims to integrate its application with the maritime division of GSAs, offering an approach to the concept, providing a management experience in the Balearic Sea (GSA 5), and supporting the thesis that a local perspective contributes to achieving the overarching goals of a fisheries policy.
Biomimetic membrane technology developments relevant to sustainable reuse of resources
Authors: Arsic Maja , Byrt Caitlin , De Rosa Annamaria , Hilder Pollyanna , Iqbal Shagufta , McGaughey Samantha , Nandala Shiva Prasad , O’Sullivan Cathryn , Wu Xing , Xie Zongli
Published: December 2024

Membrane technologies are increasingly sought to provide solutions for processes in industrial and municipal wastewater management, manufacturing, and intensified agriculture systems that were traditionally met through natural ecosystem services provided by plants and microbes in lower-intensity systems. Services like water filtration and nutrient recycling, energy conversion and generation are under increasing demand from growing urban populations and intensive agriculture. Scalable, economically viable technologies are needed to capture and recycle critical resources which are often lost in current, linear treatment pathways of complex or high-volume waste streams. This type of membrane technological advancement needs to occur, while also preserving the biodiversity of plants and microbes in their native environments, to reduce the burden that human activities place on Earth’s natural ecosystems. Specifically, biomimetic membranes that incorporate selective proteins such as aquaporins are discussed as an emerging technology that has great potential to selectively separate valuable resources from complex liquid media or wastewaters.
Políticas públicas, emergencia sanitaria y calidad de vida de la población de la provincia de Loja (Ecuador)
Authors: Moreno Alex , Jumbo Jimmy , Hernández Raquel
Published: December 2024

The global pandemic that occurred generated a health, political, economic and social crisis; for this reason, we sought to identify the Impact of Public Policies and the Health Emergency on the Quality of Life of the population of Loja-Ecuador. An applied research with a quantitative approach was carried out on a sample of 384 people. It was determined that occasionally the government establishes favorable Public Policies for Ecuadorians; that prevention measures sporadically favored health control; that vaccination allowed the mitigation of the negative impact of COVID-19 on health; and, that most of the Quality of Life conditions remain the same; except for those of physical and personal security, which have worsened. It is concluded that the Health Emergency has had a significant impact on the Quality of Life; and, that the combination of Public Policies and the Health Emergency have had a moderate impact on the Quality of Life variable.
Enhanced-efficiency nitrogenous fertilizers coupled with organic amendments: A sustainable approach to mitigating nitrogen emissions and leaching in rice-wheat cropping systems
Authors: Murtaza Ghulam , Hussain Tajammal , Zia Munir Hussain , Javed Wasim
Published: December 2024

Excessive use of nitrogenous (N) fertilizers for intensified cropping has negative environmental impacts, including the emissions of nitrous oxide (N2O) and ammonia (NH3), as well as nitrate (NO3-) leaching, however, enhanced efficiency nitrogenous fertilizers (EENFs) could be an innovative and most effective option for minimizing N losses.This study evaluated the effects of various commercially available EENFs on N losses in a rice-wheat cropping system under both saturated and aerated conditions in various incubation and lysimeter experiments. The incubation study revealed that EENFs significantly reduced NH3 volatilization and N2O emissions with coated urea products like neem-coated urea, nutraful urea, biomaterials-coated urea, and zabardast urea, compared to standard uncoated urea at both 65% and 100% water-holding capacity. In lysimeter experiments, neem-coated urea and nutraful urea achieved the highest reductions in NH3 and N2O emissions, and NO3- leaching in both rice and wheat crops. Moreover, neem-coated urea increased partial N factor productivity and partial N balance in rice (10.04%, 20.12%) and wheat (7.92%, 21.61%), respectively. The integrated use of neem-coated urea and biochar was found to be the best, as it reduced the emissions of NH3 (26.16% and 28.57%) and N2O (24.28% and 28.04%), as well as the leaching of NO3- (23.53% and 14.55%) under rice and wheat crops, respectively. As countries are committed to halving N waste by 2030 under the UN Colombo Declaration, neem-coated urea coupled with biochar is the best option for minimizing N losses and enhancing N use efficiency.
The Buffering Role of Resilience on Burnout, Depression, Anxiety, and Stress among Healthcare Workers in Sri Lanka
Authors: Baminiwatta Anuradha , Fernando Roshan , Gadambanathan Thanabalasingam , Jiyatha Fathima , Maryam Kadheeja Haniya , Premaratne Imalsha , Kuruppuarachchi Lalith , Wickremasinghe Rajitha , Hapangama Aruni
Published: December 2024

This study aimed to explore the relationship between burnout, depression, anxiety, stress, and resilience among healthcare workers (HCWs), and to investigate the moderating role of resilience against the mental health correlates of burnout. For this purpose, using a cross-sectional design, 318 HCWs from various categories (nurses, midwives, doctors, etc.) recruited from hospital and community settings in two Districts of Sri Lanka during the COVID-19 pandemic were surveyed using the Copenhagen Burnout Inventory (CBI), Depression, Anxiety and Stress Scale (DASS-21), and the Brief Resilience Scale. CBI assessed three domains: personal burnout (PB), work-related burnout (WRB) and client-related burnout (CRB). The prevalence of PB, WRB and CRB were 26.4%, 12.9%, and 7.9%, respectively. The prevalence of low, normal, and high resilience was 25.6%, 66.2%, and 8.6%, respectively. All three burnout domains correlated positively with depression, anxiety, and stress. Resilience correlated inversely with all CBI and DASS-21 scores. In moderator analysis, higher levels of resilience dampened the effects of CRB on depression and anxiety, and WRB on anxiety, but resilience moderated the psychological consequences of PB in the opposite direction. Our findings indicate notable rates of burnout among Sri Lankan HCWs, and suggest a possible buffering role of resilience against the psychological consequences of burnout.
“Not me, I’m in control!” A systematic meta-synthesis of othering amongst heavier drinkers
Authors: Morris J. , Oh E. , Verstraet L. , Bam V. , Manchanda R. , Jenkins C. L. , Mills T. , Albery I. P. , Oldham M
Published: December 2024

Othering is a discursive practice of constructing or drawing on an extreme or stereotyped problem ‘other’. Othering amongst drinking groups has been proposed as an important barrier to the resolution of alcohol problems via impeding problem recognition and increasing stigma. The aim of this review was to examine how heavier drinkers characterise a ‘problematic other’ in order to justify, normalize or protect their own ‘non-problematic’ drinking identity. A systematic search was conducted of qualitative studies where evidence of othering was identified amongst people drinking above recommended drinking guidelines. Thematic analysis was used to identify codes which were summarized into themes. A cross-cutting theme of categorizations reflected how a non-problematic drinking self versus the problematic other was constructed via labelling and identifying distinct groups or markers. Themes of control, health and functioning, drinking practices and drinking patterns were also identified in othering practices used to protect, normalize or justify participants’ own drinking. Participants used a range of discursive strategies to justify their own drinking, in contrast to the problematic other. In protecting one’s own positive drinking identity via the problematized other, othering appears a key strategy in maintaining low problem recognition amongst heavier drinking groups, in turn perpetrating harmful stigma processes.
Performance study of new aqueous binder carboxymethyl cellulose ammonia (CMC-NH4) binder for graphite anode
Authors: Wang PeiLan , Luo Na , Yang XinMiao , Zheng Weijie , Zhou ShanBing , Hu XueBu , Cai YongWei , Sun YuLing , Luan DongCun , Qiu Lei
Published: December 2024

Carboxymethyl cellulose ammonium (CMC-NH4) is cellulose by etherification reaction and dehydration of glucose on the base unit (anhydrous glucose units, AGU) hydroxy was replaced by the carboxymethyl groups partially or completely, thus forming a kind of carboxymethyl cellulose ether derivatives. In this paper, the effect of CMC-NH4 as a binder on graphite anode was investigated. Compared with CMC-Na binder, CMC-NH4 as binder showed more excellent bonding properties as well as electrochemical properties. At 0.5C, the capacity retention of Gr-CMC-NH4 after 500 cycles was improved by 15.3% compared to CMC-Na, and its capacity retention remained 81.5% after cycling. Further, the influence mechanism of different binders on the cycling performance of graphite electrodes was investigated by testing the first charge/discharge curves, cyclic voltammetry curves, electrochemical impedance before and after cycling, and analyzing the electrode SEM before and after cycling. It was found that CMC-NH4 was able to inhibit the decomposition of the electrolyte, thus enhancing the multiplicity performance. The stabilization of the excellent long cycling performance is attributed to the fact that CMC-NH4 can always provide excellent binder performance during the long cycling process to ensure the structural integrity of the electrode. Through the slurry stability test, the suspension and dispersion properties of the two binders were compared at 4, 8, 16, and 48 hours, respectively, and similar suspension and dispersion abilities were found, indicating that CMC-NH4 can be used as a graphite anode binder.In summary, this study shows that compared with CMC-Na binder, CMC-NH4 as a binder in graphite negative electrode exhibits superior bonding and electrochemical properties, and has potential application prospects.
Genetic diversity and population restructuring of Astronium fraxinifolium Schott. (Anacardiaceae) in a heavily impacted Brazilian Savanna (Cerrado) anthropic area
Authors: Alcantara Marcelo Augusto Mendes , Cornacini Maiara Ribeiro , Manoel Ricardo Oliveira , Silvestre Marcela Aparecida Moraes , Rossini Bruno César , Cambuim José , Alves Patrícia Ferreira , Corrêa Aparecida Juliana Martins , Zaruma Darlin Gonzalez , Moraes Mario Luiz Teixeira , Marino Celso Luis
Published: December 2024

Brazil is a characteristic country for having an energy matrix essentially linked to its river courses and the forest fragmentation resulting from these impacts causes a decrease in the number of individuals in a population, favoring the loss of genetic variation. Therefore, preserving the diversity of native plant populations in these impacted ecosystems is extremely important, such as Astronium fraxinifolium Schott (Anacardiaceae), a dioecious and an endangered species typical of the Cerrado. In this context, from a natural population of A. fraxinifolium, located in a highly degraded area of Cerrado, the present work aimed to: i) estimate the genetic variation from the measurement of silvicultural characters; ii) determine the sex ratio; iii) investigate genetic diversity and structure using eight microsatellite loci. All growth characters were significant, with average height and diameter at breast height of 10.99 m and 21.30 cm, respectively, with females being more developed than males. The coefficient of genetic variability was above 25% in all traits. The sex ratio of the population is close to balance from 1:1 to 5% of significance. The population has a total of 101 alleles from 384 individuals analyzed with 8 microsatellite loci, resulting in an average of 12.5 allelic richness, 0.706 observed heterozygosity, 0.793 expected heterozygosity and 0.111 fixation index. The results of this work show the presence of genetic variation and diversity in the quantitative and molecular analyses, with use for mother trees to collect seeds for use in conservation programs, recovery of degraded areas and breeding.
New method for Phytophthora cactorum culturing using plant host as material to prepare agar medium
Authors: Zhang Shengping , Cheng Ying , Zhao Jiaqiang , Liang Kuijing , Pu Yupeng , Xu Guoliang , Yang Zhaohui
Published: December 2024

Phytophthora cactorum, which is the pathogen of apple Phytophthora rot, has a reported plant host range of more than two hundred species. Usually, Phytophthora cactorum is cultured on V8 juice agar medium in the laboratory. While V8 juice could not be got easily in most cities of China. In theory, hosts as materials can be used for screening agar mediums of plant pathogen. However, little work has been done on plant hosts as materials to screen agar mediums of Phytophthora cactorum. In this study, we used chamber assays to determine the host plant species of Phytophthora cactorum following artificial inoculation. Subsequently, some of these healthy host tissues were individually selected as materials to screen agar mediums of Phytophthora cactorum. The results indicated that host juice, such as Pepper fruit, Tomato leaves, Oakleaf goosefoot leaves, could be used to prepare agar mediums for Phytophthora cactorum culturing. In the laboratory, these host tissues could be selected to produce agar mediums respectively for Phytophthora cactorum culturing in place of V8 juice agar medium.
Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in patients with rectal cancer : a population-based study
Authors: Zhang Siyu , Dai Gangyi , Wang Erli , Wu Yaoxuan , Tang Bing , Zhou Lihua , Guan Lijuan
Published: December 2024

This study aims to investigate the clinical characteristics of patients with multiple primary malignant neoplasms (MPMNs) and rectal cancer, as well as to identify the risk factors that impact the prognosis. A retrospective analysis was conducted on eligible rectal cancer patients utilizing the Surveillance, Epidemiology, and End Results (SEER) database. Comprehensive clinical data were incorporated, including patients' age, sex, race, marital status, clinical stage, surgery, chemoradiotherapy, tumor size, tumor differentiation, number of regional lymph nodes examined, survival time, and tumor status. Subsequently, univariate and multivariate Cox regression models were used to identify risk factors affecting the prognosis of MPMNs and rectal cancer patients. Colorectal cancer(22.16%), urological cancer (21.29%), and lung and bronchial cancer(13.13%) were the top three locations of MPMNs linked to rectal cancer. COX multivariate regression analysis showed that tumor Nx stage (HR:9.607, 95%CI: 3.004-30.726, p<0.001), receipt of systemic therapy before surgery (HR:1.578, 95%CI: 1.086-2.295, p=0.017) and number of regional lymph nodes <12 (HR:1.493, 95% CI: 1.184-1.883, P<0.001) were risk factors for poor prognosis of rectal cancer-related MPMNs, whereas a larger city population (HR:0.783, 95%CI:0.625-0.981, P=0.034) was a protective factor for good prognosis. Therefore, rectal cancer patients should be monitored for multiple primary cancers, especially colorectal, lung, and urological cancers. Prognostic markers for rectal cancer with MPMNs were "larger city population," "number of regional lymph nodes <12," "preoperative receipt of systemic therapy," and "tumor Nx stage."
Novel insight into lipid profile and ischemic stroke: contribution of non-HDL cholesterol to late onset in oldest old
Authors: Jiao Shusheng , Li Miaomiao , Zhi Jianxia , Ren Qiuxia , Zhu Yanxia , Zhou Yi , Wang Qinghua , Cheng Xiaofang
Published: December 2024

We aimed to investigate the contribution of lipid profile to late onset of ischemic stroke in oldest-old age stage. The patients with first-ever acute ischemic stroke were consecutively enrolled from 2022 to 2024. According to their first-onset age, they were divided into three groups (youngest old group, 60–79 years; middle old group, 70–79 years; and oldest old group, ≥ 80 years). Characteristics of basic and lipid data in three groups were described, and corresponding correlation and regression tests were performed. The oldest old group showed lower levels in total cholesterol, triglycerides, apolipoprotein B, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), LDL-C/HDL-C ratio and VLDL-C/HDL-C ratio, and less frequency in abnormalities of total cholesterol, triglycerides, LDL-C and VLDL-C. There were up to eleven types of combined dyslipidaemia showing less prevalence in oldest old. Eight lipid parameters were correlated with first-onset age, and non-HDL-C was finally identified as the most powerful contributor among lipid profile to late onset in all participants, with LDL-C in female and triglycerides in male. Our findings indicated that non-HDL-C should be a co-primary goal as LDL-C in dyslipidaemia management at population level, and triglycerides deserved more attention in male elderly patients.
A Preliminary Follow-Up Study on Irreversible Electroporation Therapy for Elderly Prostate Cancer Patients
Authors: Xia Zhi-Yu , Yang Jun , Xiao Fan , Xu Jin-Zhou , Zhong Xing-Yu , Wang Shao-Gang , Xia Qi-Dong
Published: December 2024

Background
Prostate cancer is a prevalent condition among elderly males, with radical prostatectomy being the standard treatment. However, this procedure can inevitably impact urinary and sexual functions. Irreversible electroporation represents an innovative therapeutic approach that employs high-voltage electrical pulses to selectively eradicate tumor cells, potentially preserving vital normal tissue.
Materials and methods
This follow-up study included 11 elderly prostate cancer patients who underwent IRE therapy from November 2021 to December 2023. The cohort was aged 66–77 years with a median preoperative PSA of 9.46 ng/mL. Based on the D'Amico risk classification criteria, patients were divided into low (n = 4), intermediate (n = 6), and high-risk (n = 1) groups. Follow-up exams were conducted every 3 to 6 months to assess PSA levels, imaging, and urinary/sexual function.
Results
Postoperatively, there was a significant decline in PSA levels across all patients, with a mean nadir of 0.78 ng/mL. The cumulative clinically significant prostate cancer recurrence rate was 27.3% at 30 months. Complications included urinary issues in 3 patients (27.3%), urethral pain in 2 patients (18.2%), and sexual dysfunction in 1 patient (9.1%).
Conclusion
This study suggests that IRE therapy is a safe and effective treatment option for elderly prostate cancer patients, with promising results in preserving urinary and sexual functions. However, the recurrence rate is higher than historical controls, indicating the need for further research to optimize treatment outcomes.
Aneurysmal Bone Cysts (Abc): Retrospective Analysis of 258 Cases
Authors: Karaca Mustafa Onur , Bozkurt Orhun Eray , Savran Merve Dursun , Özyıldıran Mustafa , Başarır Kerem , Yıldız Hüseyin Yusuf
Published: December 2024

Puspose: Aneurysmal bone cysts (ABCs) are bone tumours characterised by blood-filled cystic lesions. Management strategies for ABCs vary widely and lack consensus. This study aims to evaluate outcomes in 258 patients and investigate the factors affecting the recurrence rates.
Methods: This study is a single-centre retrospective analysis of patients diagnosed with ABC between January 1990 and December 2020. Patients who were histologically diagnosed with ABC, had available pathology, radiology, and surgery records, and were followed up for at least 24 months were included. Secondary ABCs were excluded. Presenting symptoms and location, computerised tomography (CT) and magnetic resonance imaging (MRI), treatment modalities, and recurrence were investigated.
Results: The mean age of the 258 ABC patients was 17.25 ± 12.37 years, 67.44% being under 18 years, and 12.40% under 5 years. 49.45% were female. The average follow-up duration was 47.80 ± 41.92 months. Pain was the most common presenting symptom, reported by 79.97% of patients. 5.04% were asymptomatic and diagnosed incidentally, whereas 11.63% were diagnosed following a pathological fracture. The median disease-free survival was 10 months, with the average time to first recurrence being 24.22 ± 22.14 months. Recurrence was more common in patients under 5 years of age (34.38% vs 19.03%, p=0.046) and in those with pathologic fractures (40.00% vs 18.42%, p=0.006). Conversely, recurrence was less common when burr and/or cautery was added to curettage (31.97% vs. 11.03%, p<0.001). Time to recurrence was significantly shorter in cases with soft tissue oedema (median 5 vs 12 months, p=0.010) or fluid-fluid levels (median 6 vs 12 months, p=0.038).
Conclusions: The study found that pathological fractures and age under 5 years are associated with a higher risk of recurrence in aneurysmal bone cysts. In contrast, adding electrocautery or burring to curettage significantly reduces recurrence rates.
Level of evidence: Level 3, therapeutic
Mentored multimodal prehabilitation for aortic aneurysm surgery: a pilot randomised controlled trial
Authors: Bidd Heena , Wong Danny , Colville Gary , Banugo Pele , Baldwin Melissa , Waring Heather , Zucco Liana , Radcliffe Gillian , Zayed Hany , Boghdadly Kariem El
Published: December 2024

Objectives
There is increasing evidence that prehabilitation before surgery may improve patient outcomes and should be established in perioperative care pathways. We aimed to explore the logistics of running a randomised controlled study in prehabilitation of patients having aortic aneurysm repair. Our primary objective was to assess the feasibility of recruitment, retention, and adherence to study interventions. Secondary objectives were patient outcomes such as function, quality of life and postoperative complications.
Design
: A feasibility, assessor-blinded, parallel-group, randomised controlled trial.
Methods
Following ethical approval, adults scheduled for elective open or endovascular abdominal aortic aneurysm repair were randomised to one of three groups: 1) control, current standard practice with no prehabilitation workshop; 2) non-mentored prehabilitation, a prehabilitation workshop with no further patient contact; and 3) mentored prehabilitation, a prehabilitation workshop with addition of regular mentoring for up to eight weeks after the workshop. Primary feasibility outcomes included: screening and recruitment; retention to eight-week follow-up; and maintenance of blinding. Secondary patient outcomes included complications; mortality; length of stay; quality of life; and functional outcomes.
Results
In total, 60 patients were screened, 45 were enrolled and randomised, and 43 were included in the intention-to-treat analyses. Feasibility of screening and recruitment was achieved, with 45/60 (75%) patients screened being recruited. Participant retention was achieved, with 40/43 (93.0%) of participants attending their eight-week follow-up and 23/43 (53.5%) wearing trackers for > 80% of the time. Maintenance of blinding was achieved in all patients. There were no significant differences in secondary patient outcomes.
Conclusions
A full randomised controlled trial is feasible. However, further modifications on study design and interventions are required to deliver a clinically meaningful randomised controlled trial.
Trial Registration:
clinicaltrials.gov ID: NCT04169217)
Intestinal Damage Marker as a Potential Predictor of Early Mortality after Cardiac Surgery
Authors: Taghiyev Zulfugar T. , Leweling Carina , Beier Lili-Marie , Sadowski Kevin M. , Gunkel Sophia , Arneth Borros M , Skevaki Chrysanthi , Kalder Johannes , Keschenau Paula R. , Boening Andreas
Published: December 2024

Objectives: Known associations between enterocyte injury and early mortality in adult patients following cardiac surgery highlight the critical role of timely detection and intervention. Elevated postoperative levels of intestinal fatty acid-binding protein (I-FABP) have been identified as a promising indicator for early identification of intestinal damage, potentially enhancing the risk prediction and treatment of critically ill patients after surgery. This study investigates the correlation between postoperative I-FABP levels and early mortality in patients at higher risk for early mortality undergoing cardiac surgery.
Methods: 500 consecutive patients undergoing cardiac surgery with extracorporeal circulation were enrolled. Blood samples were collected at five time points perioperatively. The target population included 101 patients at high risk for systemic inflammation identified by lactic acidosis >4 mmol/L and IL-6 >600 pg/mL; these were categorized as survivors and non-survivors.
Results: The mean age of patients in the target group was 66.5±12.3 y. Notably, 42% of patients developed septic shock within 12 hours of intensive care unit (ICU) admission, and the in-hospital mortality rate was 17%. Elevated serum I-FABP levels were significantly associated with non-survivors (MD 6945 pg/ml, 95%CI [2990.3 to 10899.8]; p=0.001), where the optimal threshold value for the I-FABP with >2527.3 pg/ml measured 12 h post-ICU admission predicted mortality with an AUC of 0.698 (95%CI [0.493-0.830], p=0.019). Univariate and multivariable logistic regression identified re-thoracotomy as a significant predictor of mortality, whereas lower age and body mass index indicated a survival advantage.
Conclusion: Serum I-FABP level at 12 h after ICU admission was able to identify patients with a high risk of mortality, with >2527.3 pg/ml as the optimal cut-off value. Even if lactate and IL-6 levels are high, they cannot discriminate between patients with/without early death risk.
Breast cancer metabolic subtypes analysis and risk prognostic models construction based on glycolysis metabolism genes
Authors: Liu Longbi , Zhen Wang , Cai Yufei , Liu Longxia , Zhang Yidan , LI Yuemeng , Liu Jintao
Published: December 2024

Glycolysis metabolism is an essential part of cancer research due to its role in cancer initiation and progression. However, its characteristics and prognostic value in breast cancer (BRCA) have not been systematically evaluated.We collected glycolysis metabolism gene expression profiles and clinical information of BRCA patients from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. After excluding individuals lacking clinical information and the presence of genetic mutations, we performed consistent clustering of the remaining patients based on glycolysis metabolism gene expression profiles and selected stable clustering results to group patients. Differentially expressed genes (DEGs) and gene set enrichment analysis (GSEA) were compared between subgroups, while metabolic signature identification and decoding the tumor microenvironment were performed. In addition, we explored the survival status of patients among different subgroups and identified signature genes affecting survival by Least Absolute Shrinkage and Selection Operator (LASSO) regression. Finally, we selected signature genes to construct risk prognostic models by multivariate Cox regression.By consensus clustering, patients were distinguished into two stable subpopulations, GSEA and metabolic signature identification effectively defined two completely different subtypes of glycolysis metabolism: glycolysis hyperactive subtype and glycolysis hypoglycemia subtype. Among them, patients with the glycolysis hyperactive subtype had a poorer prognosis, with a significantly lower proportion of Macrophages M1 infiltration within the tumor microenvironment than others. Eight key genes, DEP domain containing 1(DEPDC1), Ras related GTP binding D(RRAGD),Phosphoglycerate kinase 1(PGK1),Secreted Frizzled-related Protein 2(STC2),Syndecan-1(SDC1), Lactate Dehydrogenase A(LDHA) ,Calpain 5(CAPN5),calcium channel, voltage-dependent, alpha 1H subunit(CACNA1H), were selected by multivariate Cox regression, which constructed a risk prognostic model.Our study revealed the heterogeneity of glycolysis metabolism in BRCA patients, defined two completely distinct subtypes of glycolysis metabolism, and finally established a novel glycolysis metabolism-related risk prognostic model. The study contributes to the early risk assessment and monitoring of individual prognosis and provides data to support individualized patient treatment.