bluuebunny/crossref_metadata_2025 huggingface dataset:
Presenting library history on the library websites. A review
Authors:   Russian National Public Library for Science and Technology, Moseeva Darya S.
Published: October 2022

The author reviewed library websites to analyze the presentation of library evolution. The libraries of diverse departmental affiliation were selected for the study. Over 40 websites were analyzed. The common features and unique patterns were revealed.
In search of new users: Partnership projects for social adjustment
Authors:   L. Tolstoy Tula State Pedagogical University, Slyusarskaya Tatyana V.
Published: October 2022

The long-time experience (2000–2022) in research, education and advocating activities of Tula State Pedagogical University in cooperation with Tula Regional Special Library for the Blind is discussed. Over 20 projects are aimed at social adjustment of visually-impaired children. The students of psychology department prepared the tactile publications for disabled children and their parents based on the recommendations by leading national typhlopedagogues and the user group needs; the stages of the project are defined.
Visual media in library services
Authors:   Russian National Public Library for Science and Technology, Sokolova Yulia V. ,   Moscow State Linguistic University
Published: October 2022

The core terms for the visual media sphere are defined; visual media purpose and role in library services are examined. The examples and approximate sequence of library’s mediavisual product development are discussed.
Motivación y rendimiento académico en estudiantes de medicina humana de una universidad pública peruana
Authors: Chino-Loza Haydee , Miranda-Luque Izamar Donna , Mendizabal Nicole , Cachicatari Angelo , Huanco Diana
Published: October 2022

Objetivo: Determinar la relación entre motivación y rendimiento académico de estudiantes de Medicina Humana de la Universidad Nacional Jorge Basadre Grohmann en el año 2021. Material y métodos: Estudio observacional, analítico, transversal realizado en 88 estudiantes de segundo a sexto año matriculados en el ciclo 2021-II de la carrera de Medicina Humana de la Universidad Nacional Jorge Basadre Grohmann. Se aplicó una encuesta virtual anónima previo consentimiento informado, con instrumento adaptado de Autorregulación Académica (SRQ-A), basado en la teoría de autodeterminación sobre motivación y regulación, con cuatro subescalas que se agruparon en dos dimensiones: motivación autónoma (MA) que abarca regulación identificada y motivación intrínseca, y motivación controlada (MC) que abarca regulación introyectada y regulación externa. Se utilizaron la correlación de Pearson y la prueba de ANOVA, mediante el software STATA 14. Resultados: Los participantes en su mayoría cursaban el segundo (31,8 %) y tercer año (25 %), varones (52,3 %), con edades entre 16 a 24 años (77,3 %). Tanto la motivación autónoma (X = 30,45) como la motivación controlada (X = 21,9) no presentaron relación con el rendimiento académico (X = 14,3). El sexto año presentó mayor rendimiento académico (15,08) y el cuarto año, mayor motivación controlada (X = 23,8). Los varones presentaron mayor motivación controlada (X = 23,8) y las mujeres, mayor motivación autónoma (X = 31,5). Conclusión: La motivación no posee un impacto significativo en el rendimiento académico. Si bien se evidenció mayor motivación autónoma en contraste a motivación controlada, no logró asociarse significativamente a rendimiento académico.
Factores de riesgo asociados a la anemia ferropénica en adultos mayores
Authors: Mendoza Orcon Kevin B. , Vela Ruiz José M.
Published: October 2022

Objetivo: Realizar una revisión sistemática de diversas publicaciones científicas acerca de los factores de riesgo asociados a la anemia ferropénica en adultos mayores. Métodos: La revisión se realizó a través de la búsqueda electrónica de diversos artículos científicos relacionados con el tema. Se utilizó la pregunta PEO: ¿cuál es la asociación entre los factores de riesgo y la anemia ferropénica en adultos mayores? La fuente de búsqueda fue PubMed. Se seleccionaron los artículos publicados desde el 1 de enero de 2016 hasta el 2021. Resultados: De los 223 artículos encontrados, se descartaron 212 por no cumplir con los criterios de inclusión y exclusión, por lo tanto, quedaron 11 artículos para esta revisión. Conclusión: Diversos factores de riesgos intrínsecos y extrínsecos se asocian a la adquisición de anemia ferropénica o por deficiencia de hierro en pacientes adultos mayores.
ESPAÇOS ESCOLARES: A LACUNA ENTRE A REALIDADE E AS NECESSIDADES PARA O NOVO ENSINO MÉDIO
Authors: Baruffi Pedro Paulo
Published: October 2022

RESUMO:  O artigo discute um dos temas poucos debatidos na educação, porém extremamente necessário para o processo educacional. Os espaços escolares historicamente não são valorizados na mesma proporção da importância que eles possuem. A infraestrutura escolar ficou ainda mais importante após a lei da Reforma do Ensino Médio que dentre as tantas mudanças aumenta a carga horária nas escolas. Os alunos passam mais tempo na escola com as mesmas condições de sempre dificultando resultados diferentes. O estudo apresenta a infraestrutura das escolas estaduais de uma região específica do estado de Santa Catarina e analisa um caderno emitido pelo estado com roteiros pedagógicos dos componentes curriculares eletivos que aponta os espaços necessários para a aplicação dessas atividades. A infraestrutura da maioria das escolas da região é adequada de acordo com uma escala utilizada, porém ao analisar os espaços solicitados para os componentes eletivos, há uma verdadeira lacuna. Isso tudo reforça a ineficácia da reforma do Ensino Médio, pois não dialoga com a realidade das escolas.
 
Palavras-chave: Espaço. Infraestrutura. Reforma do Ensino Médio.
 
 
ABSTRACT: The article discusses one of the few topics discussed in education, but extremely necessary for the educational process. Historically, school spaces are not valued in the same proportion of the importance they have. School infrastructure has become even more important after the High School Reform law, which among many changes increases the workload in schools. Students spend more time at school with the same infrastructure as always, making different results difficult.
The study presents the infrastructure of state schools in a specific region of the state of Santa Catarina and analyzes a notebook issued by the state with pedagogical scripts of the elective curricular components that points out the necessary spaces for the application of these activities. The infrastructure of most schools in the region is adequate according to the scale used, but when analyzing the infrastructure requested for the elective components, there is a real gap. All of this reinforces the ineffectiveness of the reform of high school, as it does not dialogue with the reality of schools.
 
 
Keywords: Space. Infrastructure. High School Reform.
Antarmuka Sebagai Media Komunikasi Dengan Sistem
Authors: - Karpen
Published: October 2022

Antarmuka atau disebut juga denganÂ  Interface adalah kegiatan yang sering dilakukan oleh manusia pada saat menggunakan alat bantu untuk meringankan pekerjaannya. Kata ini mungkin masih asing kedengarannya. ditelinga kita, antarmuka dapat menerima komunikasi atau informasi dari penggunaÂ (user) dan sebaliknya dapat memberikan komunikasi atau informasi balik kepada pengguna yang disebut dengan User interface. Pada antarmuka menampilkan penjelasan sebagai media komunikasi dari sistem dan memberikan panduan pemakaian sistem secara menyeluruh tahap demi tahap sehingga user mengerti apa yang akan dilakukan terhadap sistem. Hal yang terpenting dalam membangun suatu antarmuka pengguna (user interface) adalah kemudahan dalam mengkomunikasikan dan memakai serta untuk menjalankanÂ sistem secara interaktif. Antarmuka sebagai media komunikasi harus dapatÂ  memberikan layanan kepada pengguna (user) secara efisien dan efektif
Presentasi Perumahan Tiga Dimensi Berbasis Multimedia pada PT. Surian Pembangunan Sejahtera Pekanbaru
Authors: Yuslami Rinaldi , Fitri Triyani Arita , - Nurjayadi
Published: October 2022

Perkembangan teknologi informasi juga diikutidengan perkembangan teknologi multimedia yangdapat digunakan dalam bidang pemasaran.Pengembang perumahan merupakan salah satu pihakyang sebaiknya menggunakan teknologi ini sebagaimedia promosi, multimedia memberikan kemudahanbagi calon konsumen untuk melihat visualisasiarsitektur rumah yang ditawarkan. Penelitian inimmenggunakan metodologi pengembangan multimediaversi luther-sutopo yang terdiri dari concept, design,material collecting, assembly, testing, distribution.Denganmembuat program aplikasi presentasiperumahan berbasis multimedia diharapkan dapatmemudahkan konsumen untuk melihat visualisasiarsitektur rumah yang ditawarkan
Model Pembacaan Sort Message Service (SMS) Menggunakan Metode Intonasi Dalam Bahasa Indonesia Berbasis Android
Authors: - Herwin , Nasution Torkis , Haryono Dwi
Published: October 2022

Keterbatasan penglihatan yang di alami olehtunanetra seharusnya tidak menyebabkanberkurangnya kemampuan dalam menggunakan mediakomunikasi. Peran teknologi dalam mencukupikekurangan yang di alami oleh individu tunanetramenjadi solusi. Desain teknologi yang tepat guna danaplikatif akan mereduksi kekurangan individusehingga mendekati atau sama dengan manusianormal. Dalam mencapai tujuan tersebut, dalamkajian ini akan dibuat penelitian untuk mengubahtulisan menjadi suara pada sort message service,sehingga setiap pesan yang masuk melalui teleponpintar dapat di ketahui maksud yang terkandung didalamnya. Untuk mencapai target tersebut akanmenggunakan metode yang digunakan ialah DiphoneConcatenation. Pembangkit suara yang digunakanadalah pembangkit surat dibuat sendiri. Hasil akhiryang didapat ialah dapat membacakan pesan denganformat teks biasa maupun singkatan dengan kecepataneksekusi sekitar 20 detik dan memiliki ekspresi kalimattanya, kalimat berita dan kalimat perintah
Implementasi Multimedia Interaktif Test Of English For International Communication ( TOEIC )
Authors: - Nurjayadi , Andesa Khusaeri
Published: October 2022

Seiring berkembangnya teknologi didunia kerja saat ini maka semakin banyak perusahaan yang memerlukan tenaga kerja yang mempunyai skill yang berkualitas dan terdidik, hal ini tidak lepas dari kemampuan pekerja dalam memahami Bahasa Inggris, karna semua orang tahu bahwa bahasa inggris. Kurangnya minat orang untuk mau belajar TOIEC ini juga di karenakan mahalnya biaya untuk ikut kursus atau bimbingan di lembaga pendidikan swasta menjadi salah satu masalah utama. Dari hal tersebut dapat dirancang dalam bentuk sebuah aplikasi Multimedia Interaktif untuk TOEIC dengan menggunakan komputer agar diterapkan ke lembaga-lembaga pendidikan.
Perancangan Sistem Pengelolaan Data Aktiva Tetap dan Penyusutan Nilai Aset dengan Metode Straight Line
Authors: Zoromi Fransiskus
Published: October 2022

STMIK Amik Riau merupakan salah satu perguruan tinggi komputer yang berada di kota Pekanbaru yang secara khusus di provinsi Riau. Aktiva tetap dan aset bergerak pada STMIK Amik Riau sangat banyak beragam dan telah berjumlah hampir ribuan item jenis barang namun secara pengelolaan baik secara data belum terdata dengan baik dan perhitungan penyusutan nilai aset bergerak belum dapat diperkirakan tahun demi tahun. Dalam permasalahan ini dan penelitian ini penulis memberikan solusi dengan membuat program aplikasi dan menerapkan metode perhitungan nilai penyusutan aset bergerak yaitu metode Straight Line. Metode Straight line merupakan salah satu metode yang cukup banyak digunakan dalam menghitung nilai penyusutan suatu aset bergerak. Perhitungan penyusutan nilai aset di STMIK Amik Riau saat ini telah dapat diperkirakan penyusutannya setiap tahun dengan adanya program aplikasi yang telah dihasilkan dari proses penelitian yang dilakukan.
Keamanan Jaringan Menggunakan IDS/IPS Strataguard sebagai Layanan Kemanan Jaringan Terpusat
Authors: Santoso Joko Dwi
Published: October 2022

Jaringan komputer terus mengalami perkembangan, baik dari skalabilitas, jumlah node dan teknologi yang digunakan. Hal ini memerlukan pengelolaan jaringan yang baik agar ketersediaan jaringan selalu tinggi. Tugas pengelolaan jaringan yang dilakukan administrator jaringan memiliki banyak permasalahan, diantaranya yang berkaitan dengan keamanan jaringan komputer. Intrusion Detection Sistem (IDS) atau Sistem Deteksi Penyusupan adalah sistem komputer (bisa merupakan kombinasi software dan hardware) yang berusaha melakukan deteksi penyusupan. IDS akan melakukan pemberitahuan saat mendeteksi sesuatu yang dianggap sebagai mencurigakan atau tindakan ilegal. IDS tidak melakukan penceahan terjadinya penyusupan. Pengamatan untuk melakukan pemberitahuan itu bergantung pada bagaimana baik melakukan konfigurasi IDS. Penelitian ini ditujukan untuk mengurangi permasalahan pada jaringan di lingkungan Universitas AMIKOM Yogyakarta, yang pada akhir â€“ akhir ini banyak terdapat serangan dari dalam dan dari luar. Adapun metode penerapan penelitian ini akan di tempatkan pada layanan Network-Based dan Host-Based, sehingga pola keamanan jaringan menjadi terpadu dan mudah untuk proses monitoring.
Analisa Aplikasi Power Generation Transmition Geographic Information System (PGT GIS) Terhadap Kinerja di Chevron Pacific Indonesia
Authors: - Mirhot Stewart Sihombing , - Tashid
Published: October 2022

Aplikasi Power Generation Transmition Geographic Information System (PGT GIS) adalah aplikasi yang dibuat oleh departemen PGT untuk membantu pekerjaan maintenence yakni dengan cara menemukan koordinat lokasi kerja, keberadaan pole (tiang listrik), memonitor pertumbuhan pohon tinggi di bawah powerline. Namun kenyataannya terdapat ketidakakuratan data yang ditampilkan pada aplikasi ini yang menyebabkan kinerja menjadi terganggu. Oleh karena itu perlu dilakukan analisa terhadap sistem aplikasi GIS dan menganalisa seberapa besar pengaruh terhadap maintenence di PGT menggunakan metode PIECES yaitu: Performance, Informations and data, Economics, Control and security, Efficiency, danÂ  Service. Hasil dari penelitianÂ  ini nantinya akan menunjukkan bahwa terdapat beberapa keunggulan atau kekuatan sistem yang dapat menunjang proses maintenence di perusahaan. Tetapi hasil penelitian iniÂ  juga memperlihatkan kekurangan dan kelemahan sistem, sehingga sistem yang ada ini perlu adanya perbaikan ataupun penyempurnaan menuju ke arah yang lebih baik lagi
Analisa dan Implementasi Transformasi Analog to Digital Converter (ADC) untuk Mengkonversi Suara Kebentuk Teks
Authors: - Elgamar Syam
Published: October 2022

Teknologi telah banyak membawa perubahan pada kehidupan manusia, sehingga memberikan dampak positif dan negatif. Menurut hasil beberapa penelitian menunjukkan bahwa daya serap manusia terhadap sebuah informasi adanya ketidaksamaan tingkatan, salah satu yang menyebabkan demikian adalah pilihan jenis media yang digunakan. Jenis media komunikasi audio visual ternyata yang paling tinggi, audio, dan selanjutnya berupa teks. Transformasi Analog to Digital Converter (ADC) merupakan piranti yang berfungsi merubah sinyal analog menjadi sinyal digital. Dalam sub sistem ADC,untuk mendapatkan frekuensi yang di inginkan, melalui tiga tahapan yaitu sampling, quantizing, dan pengkodean, kemudian membandingkan frekuensi ini dengan frekuensi sinyal digital suara yang masuk dengan database kata-kata yang sudah di inputkan sebelumnya sehingga menghasilkan sebuah output berupa text-on-screen
MULTILINGUALISM IN SOCIAL MEDIA: INDONESIAN K-POP FANS LANGUAGE CHOICES ON TWITTER
Authors: Febrianti Yusnita , Azzahrah Fathimah , Yannuar Nurenzia , L. Zen Evynurul
Published: October 2022

This research paper aims to identify multilingualism and language choice by looking at types of code-switching and code-mixing techniques practiced by Indonesian K-Pop fans on Twitter. Also, it examines the rationales and functions of such practice, especially as it is done in Indonesian context. Two data collection methods are used in this research. First, data were taken from several Indonesian K-pop fanbase accounts on Twitter from September 2020 to May 2021. Additionally, we also obtained data through an open-ended questionnaire participated by Indonesian K-pop fans. Our research shows that Indonesian K-Pop fans frequently implement code-switching and code-mixing techniques by combining Indonesian, English, Korean, and Japanese into their tweets. Words, phrases, and clauses from multiple languages are used. The results also show that fans practice code- switching and code-mixing in order to project a more globalized impression, create a friendly conversation, synchronize perceptions, boost language skills, and form identity.
PENGEMBANGAN BAHAN AJAR MENYIMAK BERBASIS KOPI BAGI PEMELAJAR BIPA TINGKAT PEMULA
Authors: Nirmalasari Yohanna
Published: October 2022

Bahan ajar merupakan salah satu keterampilan reseptif dalam berbahasa yang bisa mempengaruhi kualitas keterampilan yang lain. Bahan ajar menjadi komponen penting dalam jalannya sebuah pembelajaran, termasuk pembelajaran BIPA. Sebuah bahan ajar dalam pembelajaran BIPA dapat dikembangkan sesuai kondisi, karakter pemelajar, kurikulum, dan juga pendekatan yang digunakan oleh pengajar, misalnya saja di dalam pendekatan diskret. Di dalam pendekatan diskret, keterampilan berbahasa diajarkan secara terpisah sehingga bahan ajar yang digunakan juga bisa terpisah. Namun selama ini belum banyak bahan ajar yang dikembangkan khususnya terkait dengan keterampilan menyimak sehingga hal ini perlu dilakukan. Bahan ajar yang dikembangkan menggunakan metode pengembangan 4D. Hasil data dalam metode ini berupa data kualitatif dan kuantitatif. Berdasarkan data yang diperoleh dapat disimpulkan bahwa bahan ajar BIPA menyimak dengan menggunakan KoPi atau Kode Pintar sudah baik dan dapat diterapkan dalam pembelajaran BIPA. Hal ini didukung dengan presentase penilaian yang diperoleh dari tim uji ahli sebesar 97,72% dan dari tim uji lapangan sebesar 97,8%.
THE FUTURE: 3D MANUFACTURING OF MEDICAL DEVICES
Authors:   Medtronic, California, USA, Panwar Ajay , Shangari Jasdeep ,   Zest Dental Solutions, California, USA
Published: October 2022

-Three-dimensional (3D) printing is the future in the manufacturing world; its applications are widely applicable from the construction industry, engine components, replacement parts, oil and fuel tanks, welding, and manufacturing medical devices. It allows transforming designs in the digital environment into physical objects using layers manufacturing methods. Specifically, in the medical segment, 3D manufacturing is spreading faster since it will enable the unique customization to meet the patient's needs, such as heart valve design, and for physicians such as a unique ergonomic surgical tool to increase useability, thus positively impacting patient outcome. Various 3D manufacturing technologies depending upon the material have made it possible to achieve a variety of applications and provide a competitive cost advantage. However, like any other new technology, 3D printing is no different in facing the challenges in its adoption. It is imperative to take a deeper dive to discuss 3D manufacturing in the medical device industry, current 3D printer technology, its applications in the medical industry, and finally, the manufacturing and product design challenges
DESIGN OF RECONFIGURABLE SLOT ANTENNA USING VARACTOR DIODE AT FREQUENCY 4.5GHZ
Authors: Aole Kratika , Mittal Shivani , Jain Rachit ,   ITM, Gwalior
Published: October 2022

In this Research Paper, reconfigurable slot antenna for LTE (2.6GHz), AMT-fixed service (4.5GHz), and WLAN (5.4GHz) applications is displayed. There are two L-shaped slots and a U-shaped slot placed in the ground plane. The size of the antenna is short down as a result of these slots. There are three varactor diodes placed in these slots. This is done for the intention of frequency, directivity, and polarization reconfiguration. The directivities and polarization conditions of the antenna are changed at various frequencies i.e. at 2.6GHz, 5.4GHz, and at 4.5 GHz. These three various types of frequencies correspond to different states of the antenna. The states of the antenna are swapped by redirecting the varactor diodes on and off. The varactor diodes are used in this paper as they have the characteristic of fast frequency tuning.
Sosyolojik Düşünme, Sosyolojik Düşünce ve Sosyolog İlişkisi Üzerine Bir Deneme
Authors: SÖNMEZ Hümeyra , SUCU İlyas
Published: October 2022

Sosyolojiyi bir bilim olarak insan ve toplumla ilgili diğer bilim dallarından ayıran sadece sosyolojinin kendi inceleme nesnesinin farklılığı ve yöntemi değildir. Aynı zamanda toplumsal olay ve olguları “sosyolojik düşünme” dediğimiz bir zihinsel çerçeve içerisinde ele alışıdır. Bu çalışmada sosyolojik düşünmenin, çok nedenlilik, bütünsellik, disiplinlerarasılık, özdüşünümsellik, tarihi kavrayış gibi birden çok özelliğiyle birlikte sosyoloğu, rastgele düşünmekten farklılaştıran yönü ele alınmaktadır. Bu sayede sosyolog, sosyal yapıların dış yüzeyinin ötesini görmeye ve sosyal olay ve olguları daha geniş bir perspektiften ele almaya başlar. Sosyolojik düşünme, sosyoloğa dünyayı anlama ve değerlendirme hususunda önemli bir zihinsel çerçeve sunar. Bu zihinsel çerçeve ya da sosyolojik tahayyülü sosyolog, sosyolojik düşünce geleneğiyle kurmuş olduğu irtibatla edinir. Sosyolojik düşünce geleneği, sosyologların toplumla ilgili sistemli bilgilerinin toplamı olarak bir sosyolojik fikirler bütünüdür. Sosyolog, bu düşünce geleneğiyle toplum arasında yer alır. Bir taraftan bu gelenek ve düşünme biçimiyle sosyolojik bilgiyi üretir, diğer taraftan da hem sosyolojik geleneği hem de sosyolojik tahayyülü besler, zenginleştirir. Bu çalışma, sosyoloğun kendi düşünce geleneği ve düşünme biçimi ile ilişkisini sorgulamaktadır. Çalışmada öncelikle sosyolojik düşüncenin neliği tartışılacak ve bu düşüncenin özellikleri tespit edilecektir. Peşi sıra ise sosyoloğun düşünce geleneğiyle irtibatı, kendi konumu ve sosyolojik düşünmeyi nasıl edindiği ele alınacaktır.
SAĞLIK ÇALIŞANLARININ ÇOCUKLUK ÇAĞI OTİZMİ HAKKINDA BİLGİ DÜZEYLERİNİN ÇEŞİTLİ DEĞİŞKENLER AÇISINDAN İNCELENMESİ
Authors: ARSLAN Rukiye , YANIK Derya
Published: October 2022

Bu çalışma, sağlık çalışanlarının çocukluk çağı otizmi hakkında bilgi düzeylerinin çeşitli değişkenler açısından incelenmesi amacıyla yapılmıştır. Tanımlayıcı kesitsel olarak planlanmış olan bu çalışma, Türkiye’nin Güneydoğu Bölgesi’nde bulunan bir ilde Sağlık Bakanlığı’na bağlı Eğitim ve Araştırma hastanesinde yürütülmüştür. Çalışmanın evrenini, tanı/tedavi sürecinde aktif rol alan 336 sağlık çalışanı oluşturmuştur. Araştırma, veri toplama formlarını eksiksiz dolduran 210 sağlık personelinin katılımı ile tamamlanmıştır. Araştırmanın verileri; “Sosyo-Demografik Özellikler Bilgi Formu” ve “Sağlık Çalışanlarının Çocukluk Çağı Otizmi Hakkında Bilgi Anketi” kullanılarak toplanmıştır. Verilerin analizi SPSS 24.0 istatistik paket programı kullanılarak yapılmıştır. Çalışmaya katılan sağlık çalışanlarının %42.4’ü 26-35 yaş aralığında, %65.2’si kadın, %56.7’si lisans mezunu, %68.6’sı hemşire/ebe pozisyonunda çalışmaktadır. Çalışmaya katılan sağlık çalışanlarının “Sağlık Çalışanlarının Çocukluk Çağı Otizmi Hakkında Bilgi Anketi” puan ortalamaları 10.99±4.66 olarak bulunmuştur. Çalışmaya katılan sağlık çalışanlarının cinsiyet, OSB’li hastası olma ve OSB hakkında eğitim alma durumu ile çocukluk çağı otizmi hakkında bilgi düzeyleri arasında istatistiksel olarak anlamlı bir ilişki bulunmuştur (p<0.05). Lisans ve lisansüstü mezunu sağlık çalışanlarının çocukluk çağı otizmi hakkındaki bilgi düzeyinin lise mezunu sağlık çalışanlarından yüksek olduğu (F:8.006, p<0.001) belirlenmiştir. Çalışmamızdan elde edilen sonuçlara göre sağlık çalışanlarının cinsiyet, eğitim durumu, görevi, OSB’li hasta bakma ve OSB hakkında eğitimi alma durumu gibi çeşitli değişkenlerin sağlık çalışanlarının çocukluk çağı otizmi hakkında bilgi düzeyini etkilediği sonucuna ulaşılmıştır.
Promosi Dan Pemasaran Hasil Pertanian Skala Rumah Tangga Di Masa Pandemi Covid 19
Authors: Hamzah Awaluddin , Iskandar Iskandar , Rianse Ilma Sarimustaqiyma , Salahuddin Salahuddin , Limi Muhammad Aswar
Published: October 2022

The Covid-19 pandemic has had an impact on various aspects of human life, including agriculture. Although affected, agricultural land can be a solution to the crisis. Food and economic security are very basic problems for households in the life of urban communities. The problem faced by the community in promoting and marketing household-scale agricultural products during the COVID-19 pandemic in Mokoau Village, Kambu District, Kendari City, is the lack of knowledge and skills in making promotional materials and marketing household-scale agricultural products by utilizing information technology and digital-based communication (internet); lack of knowledge and skills in implementing strategies for promotion and marketing of household-scale agricultural products by utilizing digital-based information and communication technology (internet). Based on the results of the implementation of this thematic KKN integrated community service activity, it can be concluded that the community can understand the importance of promoting digital-based horticultural agricultural products during the Covid-19 pandemic. The public is able to know and apply marketing techniques using internet media during the Covid-19 pandemic. The community is able to produce promotional video content for horticultural products and upload it on YouTube media. There is a new motivation from the community in utilizing unused land around settlements for horticultural farming development land. Community participation to take advantage of thematic KKN activities is still relatively low, due to various obstacles and their respective activities. People are increasingly aware of increasing their ability to take advantage of advances in information technology as an important medium for the success of marketing horticultural agricultural products.
Budidaya Ubi Jalar Kaya Antosianin Model Pot Karung Vertikultur
Authors: Muhidin Muhidin , Yusuf Dewi Nurhayati , Leomo Sitti , Anas Arsy Aysyah , Sutariati Gusti Ayu Kade , Rakian Tresjia Corina , Nuraida Waode , Erawan Dedi
Published: October 2022

The sweet potato (Ipomoea batatas L). has significant potential as a source of carbohydrates in Indonesia The purple hue of sweet potatoes is a result of natural pigments known as anthocyanins. As antioxidants and free radical scavengers, anthocyanin chemicals have a crucial role in combating aging, cancer, and degenerative disorders. In addition, anthocyanins possess anti-mutagenic and anti-carcinogenic properties, as well as the capacity to prevent liver function abnormalities, act as antihypertensives, and reduce blood sugar levels. Given the numerous benefits of anthocyanin content, the presence of anthocyanin compounds as a source of natural antioxidants in purple sweet potatoes is highly intriguing. Alongside the growing public knowledge of healthy living, consumer food preferences are also altering. Foods that are beginning to be in high demand among consumers have an appealing appearance and flavor, as well as specialized physiological benefits for the human body. The presence of anthocyanin compounds in purple sweet potato makes this type of food very attractive to be processed into foods with functional value. On the one hand, with the increasingly limited land area, the potential for developing agricultural products, including sweet potatoes, is also increasingly limited. Meanwhile, on the other hand, the yard business model owned by households is not utilized optimally. Therefore, in providing healthy food and functional food based on anthocyanin-rich sweet potatoes, it is necessary to develop and revitalize yard land by vertically developing sweet potatoes in sacks. In addition to increase the availability of functional, healthy food, this activity is also a revitalization of the use of yardland.
Relation between CarS expression and activation of carotenogenesis by stress in Fusarium fujikuroi
Authors: Ruger-Herreros Macarena , Nordzieke Steffen , Vega-Álvarez Carmen , Avalos Javier , Limón M. Carmen
Published: October 2022

Fusarium fujikuroi, a model organism for secondary metabolism in fungi, produces carotenoids, terpenoid pigments with antioxidant activity. Previous results indicate that carotenoid synthesis in F. fujikuroi is stimulated by light or by different stress conditions and downregulated by a RING finger protein encoded by carS gene. Here, we have analyzed the effects of three stressors, nitrogen scarcity, heat shock, and oxidative stress. We compared them with the effect of light in the wild type, a carS mutant that overproduces carotenoids, and its complemented strain. The assayed stressors increase the synthesis of carotenoids in the three strains, but mRNA levels of structural genes of carotenogenesis, carRA and carB, are only enhanced in the presence of a functional carS gene. In the wild-type strain, the four conditions affect in different manners the mRNA levels of carS: greater in the presence of light, without significant changes in nitrogen starvation, and with patent decreases after heat shock or oxidative stress, suggesting different activation mechanisms. The spores of the carS mutant are more resistant to H2O2 than those of the wild type; however, the mutant shows a greater H2O2 sensitivity at the growth level, which may be due to the participation of CarS in the regulation of genes with catalase domains, formerly described. A possible mechanism of regulation by heat stress has been found in the alternative splicing of the intron of the carS gene, located close to its 3′ end, giving rise to the formation of a shorter protein. This action could explain the inducing effect of the heat shock, but not of the other inducing conditions, which may involve other mechanisms of action on the CarS regulator, either transcriptionally or post-transcriptionally.
Assessment of labially impacted canines traction mode with clear aligners vs. fixed appliance: A comparative study based on 3D finite element analysis
Authors: Xia Qian , He Yao , Jia Lurong , Wang Chunjuan , Wang Weixu , Wang Chao , Song Jinlin , Fan Yubo
Published: October 2022

Purpose: The objective of this study was to evaluate and compare the biomechanical differences between clear aligner and fixed appliance in the traction of labially impacted canines based on 3D finite element analysis.

Methods: A series of patient-oriented finite element models were constructed, including a maxillary dentition with a right labially canine, maxilla, periodontal ligaments, traction attachments, and clear aligners. The two most common clinical scenarios were investigated: Scenario A: impacted canine (distal) and Scenario B: impacted canine (mesial). For each clinical scenario, three traction models with clear aligners and one fixed appliance model were established.

Results: In all four models, the impacted canines exhibited similar initial displacement tendencies of mesially rotated in Scenario A and distally rotated in Scenario B, and with small differences in periodontal ligament stress magnitude. However, the sum of the periodontal ligament stresses of the anchorage teeth in the clear aligner mode was in the range of 56.28–76.21 kPa and in the fixed appliance mode was in the range of 6.61–7.22 kPa. The maximum value of initial displacement of the anchorage teeth in the clear aligner mode was in the range of 13.71–19.72 μm, while in the fixed appliance mode was 3.10–3.92 μm.

Conclusion: For impacted canines, clear aligner mode and fixed appliance mode have little difference in biomechanical effect. However, the anchorage teeth in the clear aligner mode endure higher stress and show a more pronounced displacement tendency. In addition, the biomechanical effects of different clear aligner traction models are various but not obvious.
Factor VIII companion diagnostic for haemophilia
Authors: Hu Chunxiao , Annese Valerio F. , Giagkoulovits Christos , Barrett Michael P. , Cumming David R. S.
Published: October 2022

Haemophilia is predominantly an inherited disorder that impairs the body’s ability to make blood clots, a process needed to stop bleeding. The condition of this disease is complex to manage, but many patients do so through home therapy and often only see their core multidisciplinary healthcare team annually. There is an increasing need for patients to be able to monitor their condition efficiently at home while staying connected with their healthcare team. As a consequence, a low-cost handheld self-monitoring solution for clotting factor is required. Here we have demonstrated a suitable one-step Factor VIII companion diagnostic sensing approach based on a chromogenic assay for haemophilia A. The results show comparable performance to the gold standard method. Our approach is able to deliver accurate cost-effective results in under 5 min from undiluted human plasma. It has the potential to be able to reduce the human and monetary costs of over- or under-medication for haemophiliacs.
Bone regeneration materials and their application over 20 years: A bibliometric study and systematic review
Authors: Zhang Xudong , Li Qianming , Wang Zhengxi , Zhou Wei , Zhang Linlin , Liu Yingsheng , Xu Ze , Li Zheng , Zhu Chen , Zhang Xianzuo
Published: October 2022

Bone regeneration materials (BRMs) bring us new sights into the clinical management bone defects. With advances in BRMs technologies, new strategies are emerging to promote bone regeneration. The aim of this study was to comprehensively assess the existing research and recent progress on BRMs, thus providing useful insights into contemporary research, as well as to explore potential future directions within the scope of bone regeneration therapy. A comprehensive literature review using formal data mining procedures was performed to explore the global trends of selected areas of research for the past 20 years. The study applied bibliometric methods and knowledge visualization techniques to identify and investigate publications based on the publication year (between 2002 and 2021), document type, language, country, institution, author, journal, keywords, and citation number. The most productive countries were China, United States, and Italy. The most prolific journal in the BRM field was Acta Biomaterialia, closely followed by Biomaterials. Moreover, recent investigations have been focused on extracellular matrices (ECMs) (370 publications), hydrogel materials (286 publications), and drug delivery systems (220 publications). Research hotspots related to BRMs and extracellular matrices from 2002 to 2011 were growth factor, bone morphogenetic protein (BMP)-2, and mesenchymal stem cell (MSC), whereas after 2012 were composite scaffolds. Between 2002 and 2011, studies related to BRMs and hydrogels were focused on BMP-2, in vivo, and in vitro investigations, whereas it turned to the exploration of MSCs, mechanical properties, and osteogenic differentiation after 2012. Research hotspots related to BRM and drug delivery were fibroblast growth factor, mesoporous materials, and controlled release during 2002–2011, and electrospinning, antibacterial activity, and in vitro bioactivity after 2012. Overall, composite scaffolds, 3D printing technology, and antibacterial activity were found to have an important intersection within BRM investigations, representing relevant research fields for the future. Taken together, this extensive analysis highlights the existing literature and findings that advance scientific insights into bone tissue engineering and its subsequent applications.
SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy
Authors: Muñiz Javier Andrés , Facal Carolina Lucía , Urrutia Leandro , Clerici-Delville Ramiro , Damianich Ana , Ferrario Juan E. , Falasco Germán , Avale María Elena
Published: October 2022

Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as Alzheimer’s disease and frontotemporal dementia. The alternative splicing of exon 10 (E10) in the primary transcript produces tau protein isoforms with three (3R) or four (4R) microtubule binding repeats, which are found in equal amounts in the normal adult human brain. Several tauopathies are associated with abnormal E10 alternative splicing, leading to an imbalance between 3R and 4R isoforms, which underlies disease. Correction of such imbalance represents a potential disease-modifying therapy for those tauopathies. We have previously optimized a trans-splicing RNA reprogramming strategy to modulate the 3R:4R tau content in a mouse model of tauopathy related to tau mis-splicing (htau mice), and showed that local modulation of E10 inclusion in the prefrontal cortex prevents cognitive decline, neuronal firing impairments and hyperphosphorylated tau accumulation. Furthermore, local shifting of 3R–4R tau into the striatum of htau mice prevented motor coordination deficits. However, a major bottleneck of our previous work is that local splicing regulation was performed in young mice, before the onset of pathological phenotypes. Here we tested whether regulation of tau E10 splicing could rescue tau pathology phenotypes in htau mice, after the onset of cognitive and motor impairments, comparable to early stages of human tauopathies. To determine phenotypic time course and affected brain nuclei, we assessed htau mice using behavioural tests and microPET FDG imaging over time, similarly to diagnosis methods used in patients. Based on these analyses, we performed local delivery of pre-trans splicing molecules to regulate E10 inclusion either into the medial prefrontal cortex (mPFC) or the striatum at 6-month-old once behavioral phenotypes and metabolic changes were detected. Tau isoforms modulation into the mPFC restored cognitive performance in mice that previously showed mild to severe memory impairment while motor coordination deficit was rescued after striatal injection of trans-splicing molecules. Our data suggest that tau regulation could recover pathological phenotypes early after phenotypic onset, raising promising perspectives for the use of RNA based therapies in tauopathies related to MAPT abnormal splicing.
Alginate-modified mesoporous bioactive glass and its drug delivery, bioactivity, and osteogenic properties
Authors: Yao Haiyan , Luo Jun , Deng Yunyun , Li Zhihua , Wei Junchao
Published: October 2022

Mesoporous bioactive glass (MBG) is widely used in bone tissue repairing and drug loading. However, burst release of drug and poor compatibility with other materials limited its application. It is an effective way to modify MBG with a polymer brush to improve the properties. Herein, an alginate-modified MBG was prepared, and then, the effects of ALG on the properties of MBG were investigated. The results demonstrate that ALG could improve the drug loading efficiency, prolong drug release times, and make orderly deposition of apatite on the surface of MBG. Furthermore, MBG@ALG significantly promoted the osteogenic differentiation of MC3T3-E1 cells, demonstrating that surface modification of MBG by ALG can improve its properties, which will further broaden the application of MBG in tissue engineering.
Epiblast cells gather onto the anterior mesendoderm and initiate brain development without the direct involvement of the node in avian embryos: Insights from broad-field live imaging
Authors: Yoshihi Koya , Iida Hideaki , Teramoto Machiko , Ishii Yasuo , Kato Kagayaki , Kondoh Hisato
Published: October 2022

Live imaging of migrating and interacting cells in developing embryos has opened a new means for deciphering fundamental principles in morphogenesis and patterning, which was not possible with classic approaches of experimental embryology. In our recent study, we devised a new genetic tool to sparsely label cells with a green-fluorescent protein in the broad field of chicken embryos, enabling the analysis of cell migration during the early stages of brain development. Trajectory analysis indicated that anterior epiblast cells from a broad area gather to the head axis to form the brain primordia or brain-abutting head ectoderm. Grafting the mCherry-labeled stage (st.) 4 node in an anterior embryonic region resulted in the anterior extension of the anterior mesendoderm (AME), the precursor for the prechordal plate and anterior notochord, from the node graft at st. 5. Grafting the st. 4 node or st. 5 AME at various epiblast positions that otherwise develop into the head ectoderm caused local cell gathering to the graft-derived AME. The node was not directly associated with this local epiblast-gathering activity. The gathered anterior epiblast cells developed into secondary brain tissue consisting of consecutive brain portions, e.g., forebrain and midbrain or midbrain and hindbrain, reflecting the brain portion specificities inherent to the epiblast cells. The observations indicated the bipotentiality of all anterior epiblast cells to develop into the brain or head ectoderm. Thus, a new epiblast brain field map is proposed, allowing the reinterpretation of classical node graft data, and the role of the AME is highlighted. The new model leads to the conclusion that the node does not directly participate in brain development.
Modulation of the high-order chromatin structure by Polycomb complexes
Authors: Guo Yiran , Wang Gang Greg
Published: October 2022

The multi-subunit Polycomb Repressive Complex (PRC) 1 and 2 act, either independently or synergistically, to maintain and enforce a repressive state of the target chromatin, thereby regulating the processes of cell lineage specification and organismal development. In recent years, deep sequencing-based and imaging-based technologies, especially those tailored for mapping three-dimensional (3D) chromatin organization and structure, have allowed a better understanding of the PRC complex-mediated long-range chromatin contacts and DNA looping. In this review, we review current advances as for how Polycomb complexes function to modulate and help define the high-order chromatin structure and topology, highlighting the multi-faceted roles of Polycomb proteins in gene and genome regulation.
Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage
Authors: Pilliod Julie , Gélinas-Faucher Maude , Leclerc Nicole
Published: October 2022

In Alzheimer’s disease, Tau, a microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, and accumulates in the somato-dendritic compartment where it forms insoluble aggregates. Tau also accumulates in the CSF of patients indicating that it is released by neurons. Consistent with this, several laboratories including ours have shown that Tau is secreted by neurons through unconventional secretory pathways. Recently, we reported that VAMP8, an R-SNARE found on late endosomes, increased Tau secretion and that secreted Tau was cleaved at the C-terminal. In the present study, we examined whether the increase of Tau secretion by VAMP8 affected its intra- and extracellular cleavage. Upon VAMP8 overexpression, an increase of Tau cleaved by caspase-3 in the cell lysate and medium was observed. This was correlated to an increase of active caspase-3 in the cell lysate and medium. Using a Tau mutant not cleavable by caspase-3, we demonstrated that Tau cleavage by caspase-3 was not necessary for its secretion upon VAMP8 overexpression. By adding recombinant Tau to the culture medium, we demonstrated that extracellular Tau cleavage by caspase-3 could occur because of the release of active caspase-3, which was the highest when VAMP8 was overexpressed. When cleavage of Tau by caspase-3 was prevented by using a non-cleavable mutant, secreted Tau was still cleaved at the C-terminal, the asparagine N410 contributing to it. Lastly, we demonstrated that N-terminal of Tau regulated the secretion pattern of a Tau fragment containing the microtubule-binding domain and the C-terminal of Tau upon VAMP8 overexpression. Collectively, the above observations indicate that VAMP8 overexpression affects the intra- and extracellular cleavage pattern of Tau.
Quercetin protects porcine oocytes from in vitro aging by reducing oxidative stress and maintaining the mitochondrial functions
Authors: Jiao Yafei , Wang Yixian , Jiang Tiantuan , Wen Keying , Cong Peiqing , Chen Yaosheng , He Zuyong
Published: October 2022

Quercetin (QUE) is a component of the flavonoid family that shows various therapeutic properties, such as antioxidant effects. However, whether QUE affects porcine oocyte in vitro aging has not yet been investigated. Therefore, in this study, we applied various doses of QUE to freshly isolated porcine oocytes and found that 10 µM QUE improved the oocyte maturation rate in vitro, as reflected by the increased degree of cumulus cell expansion and first polar body extrusion. More importantly, we found that QUE reduced in vitro aging and improved the maturity level of porcine oocytes after another 24 h of culturing, accompanied by the upregulated expression levels of bone morphogenetic protein 15, growth differentiation factor 9, Moloney sarcoma oncogene, and cyclin-dependent kinase 2. In addition, we found that QUE treatment significantly reduced the intracellular reactive oxygen species levels, apoptosis, and autophagy and upregulated the expression levels of superoxide dismutase 2 and catalase in aged porcine oocytes. In addition, QUE restored impaired mitochondrial membrane potential and spindle assembly in aged porcine oocytes. Our findings demonstrate that QUE can protect porcine oocytes from in vitro aging by reducing oxidative stress and maintaining mitochondrial function.
A novel testis-enriched gene, Samd4a, regulates spermatogenesis as a spermatid-specific factor
Authors: Ahn Jinsoo , Kim Dong-Hwan , Park Mi-Ryung , Suh Yeunsu , Lee Haesun , Hwang Seongsoo , Mamuad Lovelia L. , Lee Sang Suk , Lee Kichoon
Published: October 2022

Spermatogenesis is the highly orchestrated process involving expression of a series of testicular genes. Testis-enriched genes are critical for cellular processes during spermatogenesis whose disruption leads to impaired spermatogenesis and male infertility. Nevertheless, among poorly investigated testicular genes are the mouse Samd4a and human SAMD4A which were identified in the current study as novel testis-enriched genes through transcriptomic analyses. In particular, as orthologous alternative splicing isoforms, mouse Samd4a E-form and human SAMD4AC-form containing the SAM domain were specific to testes. Western blot analyses revealed that the murine SAMD4AE-form was predominantly found in the testis. Analyses on GEO2R and single-cell RNA-seq datasets revealed that the Samd4a/SAMD4A expression was enriched in spermatids among various types of cells in adult testes. To investigate in vivo functions of Samd4a, Samd4a knockout mice were generated using the CRISPR/Cas9 system. The Samd4a deficiency resulted in lower testis weight, absence of elongated spermatids, and an increased number of apoptotic cells. Profiling of gene expression in human testis samples revealed that the SAMD4A expression was comparable between obstructive azoospermia patients and normal controls, but significantly lowered in nonobstructive azoospermia (NOA) patients. Among three subgroups of NOA, pre-meiotic arrest (NOA-pre), meiotic arrest (NOA-mei), and post-meiotic arrest (NOA-post), expression level of SAMD4A was higher in the NOA-post than the NOA-mei, but there was no difference between the NOA-pre and NOA-mei. The current studies demonstrated spermatid stage-specific expression of Samd4a/SAMD4A, and impairment of the late stages of spermatogenesis by disruption of the mouse Samd4a gene. These data suggest that Samd4a/SAMD4A plays an essential role in normal spermatogenesis, and SAMD4A, as a spermatid specific marker, can be used for subcategorizing NOA patients. Further understanding the molecular role of SAMD4A will advance our knowledge on genetic regulations in male infertility.