bluuebunny/crossref_metadata_2025 huggingface dataset:
Patellar fracture fixation using cannulated screws and Fiber Wire tension band
Authors: Bayomy Elsayed M , Shaheen Mohamed Y
Published: June 2023

Purpose

This study aims to evaluate the results of patellar fracture fixation using cannulated screws and FiberWire tension band.

Patients and methods

A prospective study was held in Benha University Hospital that included 30 patients with transverse patellar fractures fixed with cannulated screws with FiberWire tension band. All of the patients were followed up for a minimum period of 12 weeks, and the maximum period of follow-up was 24 weeks. Postoperatively, these patients were assessed clinically by the Levack’s score. Fracture union was confirmed radiologically. All patients were evaluated and assessed using the questionnaires at 3 and 6 months after surgery. Subjective evaluation consisted of recording pain using (visual analog scale), with categorization of pain into five levels: none, mild, moderate, severe, and unbearable.

Results

The mean age of the studied patients was 32 ± 9 years, and there was a male predominance (70%). More than half of the patients had right-sided affection (56.7%). The mechanisms of injury were direct (30%), falling (46.6%), or road traffic accidents (RTA) (23.3%). The affected side was the right side in 56.7% and the left side in 43.3%. The median time from injury was 3 days, and it ranged from 1 to 6 days. The mean time of surgery was 41 ± 18 min. All patients showed radiological union at 8 weeks, passive range of motion (ROM) at 4 weeks, active ROM at 6 weeks, start of weight-bearing as tolerated within brace at 4 weeks, and start of weight-bearing and ROM without restrictions at 8 weeks. At the final follow-up at 3 months, the median total Levack’s score was 12, and it ranged from 9 to 12. At 6 months, the median was 12, and the range significantly increased (11–12) (P<0.001). The reported complications were skin infection (13.3%), stiffness (6.7%), and mild pain (53.3%).

Conclusion

The use of cannulated screws with FiberWire tension band technique is a successful efficient treatment of transverse patellar fractures.
Percutaneous screw fixation with bone marrow injection in delayed fracture scaphoid, is it effective: a randomized control study
Authors: Tabl Eslam A , Essay Osama M
Published: June 2023

Background

Scaphoid is the most commonly injured carpal bone, with over two-thirds of scaphoid fractures occurring at the waist. The anatomy of the scaphoid makes these injuries susceptible to delayed unions or nonunions and can lead to significant morbidity and disability.

Aim

To evaluate the effect of bone marrow injection on bone healing in delayed presented fractures of scaphoid with percutaneous fixation via Herbert screw.

Patient and methods

Forty patients with delayed presented scaphoid fractures treated with percutaneous screw fixation and divided into two groups, group A augments the fixation with bone marrow injection, while group B suffices with fixation only.

Results

All fractures had complete union, but there is a significant acceleration in bone healing in group A than in group B with P value less than 0.05. This is reflected in the other results for group A, according to Mayo wrist score, we have 17 excellent and three good results, while in group B, there were 15 excellent, four good, and one patient with poor results due to nonunion that occurred.

Conclusion

The use of bone marrow is considered a simple and minimally invasive technique. It is safe and has no risk, so we recommend use of bone marrow injection with fixation of delayed presented fractures of scaphoid.
The Mediating Role of Social Participation in Motoric Cognitive Risk and its Relation to Depression and Loneliness in Older Adults
Authors: Park Ji Hyeun , Park Sangmi , Jung Jae Hyu , Bae Suyeong , Yun Sohyeon , Khan Anastassiya , Hong Ickpyo , Park Ji-Hyuk
Published: June 2023

Background: Motoric cognitive risk syndrome (MCR) reduces the quality of life, independence, and social interaction in older adults. Social participation is a potentially modifiable factor that benefits cognitive and mental health. This study explored the mediating roles of social participation between MCR and depression and between MCR and loneliness. Methods: We performed a secondary analysis of data from the 2015–2016 National Social Life, Health, and Aging Project. Slow gait speed and cognitive decline were used to assess MCR. Mediation analysis was applied to two models, both of which used MCR as an exposure and social participation as a mediator. The outcomes were depression and loneliness for each model, respectively.Results: Among 1,697 older adults, 196 (11.6%) had MCR. The mediating role of social participation was statistically significant in both models. The indirect effect (β=0.267, p=0.001) of MCR on depression through social participation comprised 11.97% of the total effect (β=2.231, p<0.001). The indirect effect (β=0.098, p=0.001) of MCR on loneliness through social participation was 19.48% of the total effect (β=0.503, p<0.001). Conclusion: Interventions to increase social participation may reduce depression and loneliness of older adults with MCR.
User’s Manual for the Hybrid III Large Male Test Dummy
Authors:   Dummy Testing and  Equipment Committee
Published: June 2023

This SAE Surface Vehicle Information Report identifies and defines the assembly/disassembly and certification procedures relating to the use of the Hybrid III Large Male Test Dummy.
Editorial
Authors: Mjimba Vuyo
Published: June 2023

No Abstract.
Growth responses of Clarias agboyiensis and C. macromystax fed foreign and indigenous commercial fish feed
Authors: Garba A. A. , Ikenga E. E , Suleiman M. S. , Mustapha I. S , Idris J. , Afar A. , Otuisi B. E.
Published: June 2023

The study investigated growth responses of the small fish, Clarias agboyiensis and C. macromystax fed with foreign (Coppens and Al aqua) and indigenous (Vital and Blue crown) commercial catfish feed. Fish were grouped into four categories: AA1 to AA4 represented C. agboyiensis fed with Coppens; BB1 to BB4 represented C. macromystax fed with Al aqua; CC1 to CC4 represented C. agboyiensis fed with Vital while DD1 to DD4 represented C. macromystax fed with Blue crown. Fish on foreign feed were fed at 1% of their body weight once a day while those on indigenous feed were treated at 2% body weight twice daily. Each feed contained 60% crude protein. The experiment was laid out in a completely randomized block design with 16 fish in each 70 litre water container. Growth responses were estimated using standard procedure. Results showed that C. agboyiensis fed with Coppens at 1% body weight and once daily had the best average final weight of 337.37g, final length of 32.15cm, specific growth rate of 19.65%/day, condition factor of 2.95 and survival rate of 83.5 %. This was  followed by C. macromystax fed Al aqua at the same frequency and duration having a final weight of 309.25g, final length of 30.85cm, specific growth rate of 19.40%/day, condition factor of 2.95 and survival rate of 80%. The least growth response was recorded in C. macromystax fed Blue crown. The study indicated that Coppens feed has the best nutrient utilization ability. Thus, fish fed this diet even at 1% biomass and once daily produced the best growth. Therefore, fish could actually be fed once a day for growth and improved meat quality provided the feed quality is adequate.
Association between outdoor play and myopia among children in Cross River State, Nigeria. A case control study
Authors: Charles Kindness, , Ekpenyong Bernadine N. , Agbasimere Simeon C. , Okoi Edward O.
Published: June 2023

Purpose: Myopia is a refractive error of the eyes that causes blurred distance vision. Near work, genetics and environmental factors have been implicated as risk factors in Child myopia. This study seeks to determine the association between time spent on outdoor play and myopia among children in Calabar, Nigeria.

Methods: It was a hospital-based case-control study conducted among 120 children (5-17 years old) selected and matched by age and sex from out-patients of the Cross River Eye Care Program. After obtaining parental consents, assent was obtained from the children before conducting comprehensive eye examinations. Myopia was defined as a spherical equivalent of ≥-0.50D. Cases were children diagnosed with myopia and controls were those without myopia. Independent samples t-test and Spearman’s correlation were conducted and P-value < 0.05 was considered to be statistically significant at 95% confidence interval.

Results: Cases spent lesser time playing outdoors than controls (M = 1.95 vs 2.40 hours daily, p = 0.01). Spearman’s correlation found a statistically significant, weak, negative correlation between time spent on outdoor play and myopia [rs(118) = -0.217, p = 0.017]. Spending above 2 hours on outdoor play had an OR of 0.37 (95% CI = 0.170 - 0.816).

Conclusion: In this association found between time spent on outdoor play and myopia, as time spent on outdoor play increases, myopia decreases. Increased time spent on outdoor play was a protective factor against myopia. Hence it is recommended that more awareness be created on the protective effect of outdoor play.
Evaluation of phytochemical constituents, total phenolic contents and in vitro antioxidant activities of Mucuna pruriens fractions leaves
Authors: Oyinloye Oladapo. Elijah , Murtala A. A. , Oladoja F. A. , Okunye O. L. , Aderinola A. A. , Kasumu E. O.
Published: June 2023

Mucuna pruriens is a tropical annual climbing legume plant used in traditional medicine systems to treat diabetes, arthritis, dysentery, hematinics, inflammation, and cardiovascular conditions. The present study investigates the phytochemical constituents, phenolic contents and in vitro, antioxidant potentials of M. pruriens leaf fractions using spectrophotometric methods. Phytochemical screening of hexane, chloroform, ethyl acetate, and methanol fractions of M. pruriens was determined using standard methods. The antioxidant activities of the fractions were assessed against total phenolic contents, total antioxidant contents, ferric ion reducing antioxidant power assay, and 1,1-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity using standard protocols. Phytochemical screening showed that only the ethyl acetate fraction of M. pruriens leaves contain all the phytochemical constituents tested for, saponins, tannins, flavonoids, cardiac glycosides, anthraquinones, terpenoids, steroids, alkaloids, phenol. The activities of the fractions against total phenolic contents were high in ethyl acetate fraction (1.958±0.24 mg GAE/g), while chloroform fraction gave the lowest total phenolic contents (1.476±0.19 mg GAE/g). On the contrary, chloroform fraction showed more significant total antioxidant contents (2.078±0.80 mg ASCE/g). The methanol fraction demonstrated higher ferric ion-reducing antioxidant power (4.866±1.19 mg ASCE/g). The methanol fraction scavenging activity against DPPH radical exhibited a lower IC50 value of 404.92 (μg/mL) relative to other fractions. It is concluded that ethyl acetate and methanolic fractions of Mucuna pruriens leaves, which contain large amounts of phenolic compounds, exhibited high antioxidant activities. These in vitro assays indicated that Mucuna pruriens leaves fraction is a significant source of natural antioxidants, which might help prevent the progress of various oxidative stresses.
Molecular identification of trypanosoma species infecting dogs in nigeria by analysis of partial internal transcribed spacer-1 of RRNA gene
Authors: Umeakuana P.U. , Adepoju O.A. , Takeet M.I. , Chechet G.D. , Dibba L.B.S. , Ezeokonkwo R.C. , Anene B.M. , Balogun E.O.
Published: June 2023

Trypanosomosis is becoming a major health challenge to dogs in the sub-Sahara Africa including Nigeria, but minimal reports are available on the  molecular characteristic of trypanosomes infecting dogs in Nigeria. We characterized trypanosomes detected in naturally infected dogs by PCR and  sequences analysis of the partial region of the trypanosomes internal transcribed spacer-1of ribosomal RNA (ITS1 rRNA). Animals presented to the  University of Nigeria Veterinary Teaching Hospital (UNVTH) in Nsukka, Nigeria for examination and treatment were sampled for laboratory tests. DNA was  extracted from 21 blood samples obtained from dogs that were confirmed positive for trypanosome infection by microscopy. ITS-1 was PCR  amplified and sequenced bi-directionally. Sixteen samples have good bands, though one of them had unreadable sequence. Analyses of the sequence  data by BLAST search on NCBI identified T. congolense, T. brucei gambiense, and T. evansi in 4.8, 4.8, and 91.4%, respectively, from the analysed samples  from the infected dogs. Although the top BLAST hits for T. brucei group were due to T. evansi and T. b. gambiense, there is not enough discriminatory  power in ITS-1 to distinguish subspecies. The aligned sequences of the trypanozoon were less polymorphic. Phylogenetic trees inferred by unweighted  pair group method with arithmetic mean (UPGMA) algorithms separated trypanozoon group from the T. congolense into two distinct clades. In conclusion,  this study suggests that the trypanozoon group of trypanosomes cause more canine trypanosomosis in the study area and suggests inclusion of dogs in strategic planning for control and eradication of trypanosomosis in sub-Sahara African countries.
Review of man to animal transmission of coronavirus disease 2019 (covid-19) infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2)
Authors: Kareem K.O. , Adigun K.O. , Musa Z.A. , Aina O.O.
Published: June 2023

Coronaviruses infect a wide variety of animals, including birds and mammals, where they cause infection in animals, mutate and cause disease outbreaks  in humans. The review focused on the origin and spread of SARS-CoV-2 from humans to animals. A systematic literature search of PubMed,  ProMed-mail, and Google Scholar databases, using keywords "animals", "COVID-19", and "SARS-CoV-2", for articles providing information on animal  studies and case reports between December 2019 and September 2021. Published articles included in this review are in English and conducted studies on  animals and case reports of human-animal transmission. Fifty-seven COVID-19 in animals published articles featured in this review. Humans can  spread the disease to pets (dogs and cats) during close contact when they are clinically infected. Although cats are susceptible to subclinical infection,  they developed a robust neutralizing antibody response that prevented re-infection to a second viral challenge in a laboratory setting. Clinically positive  Farm workers on mink farms tend to spread the disease to the Minks. Pangolins are a natural reservoir of SARS-CoV-2-like CoVs, the Coronaviruses most  related to SARSCoV-2. Companion animals living with infected owners are at risk of Man-to-animal spread of the SARS-CoV-2 virus. Therefore, applying  basic hygiene measures such as handwashing when handling and caring for animals is suggested.
Assessment of health-related quality of life and its determinants among patients with diabetic foot ulcer in Ilorin, Nigeria
Authors: Olarinoye J.K. , Omotoso A.B. , Ogunmodede A.J. , Opeyemi C.M. , Olagbaye B.A. , Sanni N. , Aderibigbe A.B.
Published: June 2023

Background: The impact of foot ulceration on the psychosocial wellbeing of the Nigerian diabetic patients has not received enough attention. This study therefore attempted to evaluate the effect of diabetic foot ulcer on the quality of life of adults in a Nigerian diabetic population.

Methodology: The impacts of diabetic foot ulcer (DFU) on the quality of life (QoL) of 104 adults living with diabetes were assessed using The Diabetes Foot Ulcer Scale and their determinants.

Results: The mean QoL score was 42.25. Fifty-five (53.4%) had poor QoL status while 48 (46.6%) had good QoL. Determinants of poor QoL outcome include low socio-economic status (p = 0.017), lack of a tertiary education (p= 0.027), no diabetes-education (p = < 0.001), low socioeconomic status (p = 0.017), multiple ulcers (p = 0.022) and Wagner grade >3 ulcers (p = 0.004).

Conclusion: Majority of patients with DFU in UITH, Nigeria have poor QoL and most of the predictors of poor QoL outcome are preventable and modifiable.
Effect of psychoactive substance use on academic activities and performance among undergraduates of University of Lagos
Authors: Osalusi B.S. , Koleowo O. , Ogunsemi O.O. , Ogunjimi L. , Afe T.O. , Ale A. , Agboola A.O.J. , Deji-Agboola M.A.
Published: June 2023

Background: The objective of this study was to assess the effect of psychoactive substance use on academic performance among university students of Lagos undergraduates.

Methods: This is a descriptive cross-sectional study to assess psychoactive substance use and its relation to academic performance among undergraduate students of the University of Lagos. A multi-stage sampling technique was used to select the participants. Data was collected using a self-administered semi-structured questionnaire adapted from WHO model core questionnaire self-administered format. Data was collected and analyzed using the free-liscence software package Epi-Info, version 7.2.2.16. Chi square and Fisher's exact were used to test for any significant association between psychoactive substances use and academic performance of the respondents. Level of significance (p) was set at 0.05.

Result. Prevalence of psychoactive substance use was 28.6%. Male and female respondents were270 (69.77%) and 117(30.23%) respectively, with age range between 14 and 30 and mean age of 20.51 (SD)(±2.91) year. Alcohol was the most abused substance with 68.99%, this was followed by cigarette with 20.67% ever use prevalence. The mean age of first use of psychoactive substance was 16.31±3.89. Using the Grade Point Average system from the previous semester, majority of the respondents (87.08%) had GPA >2.50. Both frequency of studying and mean CGPA was statistically better among non-life time users and non-current users of alcohol, tobacco and cannabis in the male group. However there was no statical significance among female group. Using fischer exact test to assess the effect of age of first substance use and mean CGPA. The age of first substance use was statistically significant for tobacco p = 0.007.

Conclusion. Psychoactive substance use among students was common and negatively associated with students’ academic performance especially among male gender.
The genome assembly and annotation of the many-banded krait, Bungarus multicinctus
Authors: Liu Boyang , Cui Liangyu , Deng Zhangwen , Ma Yue , Yang Diancheng , Gong Yanan , Xu Yanchun , Lan Tianming , Yang Shuhui , Huang Song
Published: June 2023

Snakes are a vital component of wildlife resources and are widely distributed across the globe. The many-banded krait Bungarus multicinctus is a highly venomous snake found across Southern Asia and central and southern China. Snakes are an ancient reptile group, and their genomes can provide important clues for understanding the evolutionary history of reptiles. Additionally, genomic resources play a crucial role in comprehending the evolution of all species. However, snake genomic resources are still scarce. Here, we present a highly contiguous genome of B. multicinctus with a size of 1.51 Gb. The genome contains a repeat content of 40.15%, with a total length exceeding 620 Mb. Additionally, we annotated a total of 24,869 functional genes. This research is of great significance for comprehending the evolution of B. multicinctus and provides genomic information on the genes involved in venom gland functions.
Noi cărămizi ștampilate ale legiunii VII Claudia pia fidelis din Podul lui Traian de la Drobeta
Authors:   Academia Română, Filiala Timișoara, Institutul de Studii Banatice ", Bunoiu Victor ,   Titu Maiorescu", Matei-Popescu Florian ,   Institutul de Arheologie „Vasile Pârvan” București, Văcuță Gavril Eugen ,   Muzeul Regiunii Porților de Fier Drobeta-Turnu Severin
Published: June 2023

Construirea Podului lui Traian de la Drobeta s-a petrecut, după Cassius Dio (LXVIII 13, 1-6), îndată după încheierea păcii din 102 p. Chr. La construirea podului, au luat parte detaşamente din legiunile V Macedonica, VII Claudia, XIII Gemina, precum şi din cohortele I Cretum, II Hispanorum (scutata Cyrenaica) şi III Brittonum veterana, conform descoperirilor de ştampile tegulare (IDR II 99-105). În colecția de Arheologie a Muzeului Regiunii Porților de Fier se găsesc o serie de cărămizi ștampilate identificate în cursul cercetărilor arheologice efectuate la pilele Podului lui Traian de la Drobeta. Totodată, lucrările de restaurare desfășurate la Podul lui Traian în perioada 2020-2021 au scos la iveală informații noi privind unitățile militare care au contribuit la construirea podului.
An Archaeological look into simple pit burials at Tepe Qara Hasanlu, Namin, Ardabil
Authors:   University of Mohaghegh Ardabili, Ardabil, Tahmasebi Fariborz , Rezalou Reza ,   University of Mohaghegh Ardabili, Ardabil, Javanmardzadeh Ardashir ,   University of Mohaghegh Ardabili, Ardabil, Aghdam Esmaiel Maroufi ,   University of Mohaghegh Ardabili, Ardabil
Published: June 2023

Excavations at the historical mound of Qara Hasanlu, in the Namin County of Ardabil Province of northwestern Iran, brought to light several pit graves set on a massive mudbrick artificial platform. Cut into the uppermost courses of the mud bricks forming this platform, the graves were associated with scores of burial gifts of varied types such as arrowheads, daggers, scissors, mirrors, earrings, and necklaces. As a descriptive-analytical work drawing upon both field and library research, the present paper is set to characterize the recorded grave types and their relative chronology in quest of tenable answer to these questions: 1. What were the grave types and mortuary customs at Qara Hasanlu? 2. Where do they find parallels, and to which period do they belong to? Within the graves, the bodies were laid out in two supine and squatting positions. Based on the available circumstantial evidence, they were made sometime after the platform was constructed. The documented cultural material including sherd assemblages, the burial methods and the burial gifts suggested a date in the Parthian period for the site.
Characterization of residues found within some Roman unguentaria glass artefacts: preliminary results of a multi-disciplinary approach
Authors:   National Institute of Research and Development for Optoelectronics - INOE 2000, Măgurele, Cortea Ioana Maria , Țentea Ovidiu ,   Department of Archaeology, National Museum of Romanian History, Bucharest
Published: June 2023

Despite the large number of unguentaria vessels generally discovered in Roman archeological sites, very little information is available concerning the nature and chemical composition of the products that were originally contained within these artifacts. In this study a combined non-destructive approach that included Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy and X-ray fluorescence was used for the characterization of some brownish-black residues preserved in a series of glass unguentaria recovered from excavations at the Roman baths from Mălăiești. The obtained results highlighted the presence of different inorganic substances (an earth-based pigment rich in iron and manganese oxides, admixed with traces of lead- and mercury-based compounds) impregnated with an organic binder such as animal glue and possible natural essential oils, a powdered product associated most probably with a cosmetic/pharmacological use. The study allowed a first insight into the composition and origin of these ancient remains, providing important clues that may help to understand the original function of these unguentaria vessels.
Prediction of Maternal Health Risk with Traditional Machine Learning Methods
Authors: MUTLU Hursit Burak , DURMAZ Fatih , YÜCEL Nadide , CENGİL Emine , YILDIRIM Muhammed
Published: June 2023

Riskli gebeliklerde, gebelik öncesinde anne adayının sahip olduğu kalp, akciğer, böbrek, yüksek tansiyon, diyabet ve karaciğer gibi çeşitli hastalıklar, gebelik sırasında anne adayının durumunu kötüleştirebilir. Anne yaşı, kalp atış hızı, kan oksijen seviyesi, kan basıncı, vücut sıcaklığı gibi tıbbi parametreleri analiz ederek ve bu parametrelere karşılık gelen değerleri inceleyerek, bazı hastalar için risk yoğunluğuna ilişkin bilgi tahmin edilebilir. Belirtilerde erken aşamada risk faktörleri sınıflandırılarak, gebelikle ilgili komplikasyonları azaltmak mümkündür. Anne risk sağlığını belirlemede makine öğrenimi yöntemlerinden yararlanmak mümkündür. Bu nedenle, bu çalışmada anne risk sağlığını belirlemek için 6 farklı makine öğrenimi yöntemi kullanılmıştır. Bu yöntemlerde elde edilen sonuçlar birbirleriyle karşılaştırılmış ve anne risk sağlığını tahmin etmede en başarılı yöntemin Karar Ağacı olduğu görülmüştür. Karar Ağacı yönteminde elde edilen doğruluk değeri %89,16’dır. Makalede kullanılan yöntemler arasında en düşük doğruluk oranı k-en yakın komşu (KNN) yöntemi ile elde edilmiştir ve bu oran %68,47'dir.
Gender Detection by Acoustic Characteristics of Sound with Machine Learning Algorithms
Authors: MIZRAK Hamit , ASLAN Serpil
Published: June 2023

Sound has been studied in almost every field since the existence of humans, and sound science branches have emerged due to its increasing importance day by day. Sound has been studied in many fields from the past to the present, and it has become an essential factor in people's understanding of each other. It is possible to determine the voice of individuals with the help of computers in the digitalized world to determine the speech acoustics and the gender of that voice and to determine it with the prediction algorithms in machine learning by utilizing the characteristics of the voice's characteristic metric performance criteria. In this study, six different machine learning algorithms were used. By comparing these machine learning algorithms, prediction results were obtained to determine the best prediction result and the gender difference by using the voice characteristics of individuals.
Synthesis and Characterization of Cellulose Based Injectable Polyurethane Gels
Authors: EMRE Fatma Bilge , KIVILCIM Fadime Nülüfer
Published: June 2023

This article describes the synthesis and characterization of cellulose-based injectable polyurethane gels for tissue engineering applications. The gels were prepared by combining a cellulose derivative with a polyurethane precursor and crosslinking agent to form a stable gel under physiological conditions. The resulting gels were evaluated for swelling behavior.

The addition of cellulose to polyurethane is a promising approach to improve the properties of polyurethane. Cellulose is an abundant, environmentally friendly and inexpensive polysaccharide polymer widely used in hydrogels, pharmaceuticals and agriculture. The obtained cellulose-based polyurethane composites were characterized in detail using various techniques such as Fourier transform infrared spectroscopy (FTIR), Thermogravimetric Analyzer (TGA), Differential Scanning Calorimeter (DSC), Differential Thermal Analysis (DTA), swelling test measurements and optical microscopy. The results showed that the obtained composites are suitable for the production of injectable insulating materials. The paper also briefly discusses the various uses of polyurethanes in different fields, including furniture manufacturing, medical devices such as hospital beds, catheters, injection-coated devices, wound dressings and surgical dressings, as well as marine, air and land vehicles. In conclusion, this paper provides valuable insights into the development of cellulose-based injectable polyurethane gels for tissue engineering applications and highlights the potential of cellulose as an additive to enhance the properties of polyurethane. The results of this study may contribute to the development of new and improved biomaterials for tissue engineering applications.
Pulmoner Hipertansiyonu Olan Hastanın Gordon’un Fonksiyonel Sağlık Örüntüleri Modeline Göre Hemşirelik Bakımı: Olgu Sunumu
Authors: AVCI Abdullah , GÜN Meral
Published: June 2023

Nadir görülen, tanı ve tedavisinde en çok zorluk yaşanan hastalıklardan biri olan pulmoner hipertansiyon, vasküler direnç artışı ile zamanla sağ kalp yetersizliğine ve ölüme yol açan kompleks ve progresif bir hastalıktır. Pulmoner hipertansiyon daha çok genç kadınlarda görülmekte ve Dünya’daki prevalansı tam olarak bilinmemektedir. Pulmoner hipertansiyonu olan hastaların deneyimlediği semptomlar fonksiyonel kapasitenin kısıtlanmasına ve günlük yaşam aktivitelerinin sınırlanmasına neden olarak yaşam kalitesini azaltmaktadır. Prognozun kötü seyretmesinin yanı sıra tedavi ve bakımının karmaşık olması hastaların sistematik bakım gereksinimini arttırmaktadır. Hemşirelik uygulamalarında teori ve modellerin uygulamaya aktarılmasıyla mesleğe özgü uygulamalar sistematik ve standart hale gelmektedir. Olgu, bireyleri biyopsikososyal boyutta ele alan ve bireylerin gereksinimlerini 11 fonksiyonel alanda açıklayan Gordon’un Fonksiyonel Sağlık Örüntüleri modeli ile değerlendirilmiş, Kuzey Amerika Hemşirelik Tanıları Birliği hemşirelik tanıları doğrultusunda hemşirelik bakımı planlanmış ve uygulanmıştır.
OSMANLI DEVLETİ’NİN MİLLİ İKTİSAT POLİTİKASI ARAYIŞI BAĞLAMINDA AYDIN VİLAYETİ SEYYAR ZİRAAT VE RENÇBERLİK SERGİSİ
Authors: Berci İbrahim
Published: June 2023

Osmanlı Devleti’nde 20. yüzyıl başları, siyasi ve iktisadi düşünce değişimlerinin hız kazandığı bir dönem olmuştur. Özellikle II. Meşrutiyet’in ilanından sonra bu değişimler toplum tabanında etkisini göstermeye başlamıştır. Bu dönemde açılan sergiler arasında Aydın Vilayeti Seyyar Ziraat ve Rençberlik Sergisi, hem ilk demiryolu ziraat sergisi olması hem de köylünün zirai makineleri öğrenip kullanması bakımından diğer sergilerden farklıdır. Üstelik bu sergi, Osmanlı Devleti’nde Türkçülük akımı ve milli iktisat düşüncelerinin hararetle tartışıldığı ve bu tartışmaların toplum tabanında karşılık bulmaya başladığı bir dönemde gerçekleşmiştir. Bu çalışmada dönemin değişen düşünce yapısına bağlı olarak Osmanlı Devleti’nin milli iktisat politikasına geçişi anlatılmıştır. Ayrıca Aydın Vilayeti Seyyar Ziraat ve Rençberlik Sergisi tanıtılmış ve toplum tabanındaki yansımaları tartışılmıştır. Bu çalışmanın ana kaynaklarını İzmir şehrinde yayımlanan Türkçe süreli yayınlar ve dönemle ilgili yazılmış olan araştırma eserler oluşturmaktadır.
Influência no proteinograma e no estresse oxidativo em éguas acometidas e não acometidas com endometrite
Authors:   , Argumedo Jiménez Ana Karina
Published: June 2023

A endometrite é a principal causa de subfertilidade e infertilidade nas éguas. O presente estudo teve o objetivo de analisar o proteinograma e o status oxidativo no soro e fluido uterino de éguas saudáveis e acometidas por endometrite. Foram utilizadas 15 éguas no estro, as quais foram divididas em dois grupos, éguas com endometrite (grupo doente, n=8) e éguas sem doenças reprodutivas (grupo sadio, n=7). Foram colhidas amostras de sangue e do fluido uterino para análise em eletroforese monodimensional em gel de poliacrilamida das proteínas presentes no soro e no fluido uterino, assim como se avaliou a atividade de substâncias oxidantes e antioxidantes. Foi observada diferença estatística significativa em sete das 10 proteínas avaliadas no soro de éguas acometidas com endometrite e éguas sadias neste estudo, entre elas a α2 – macroglobulina (α2–macro); haptoglobina (Hp; e apolipoproteína A1 (Apo A1), quando p < 0.05. No fluido uterino, de identificaram bandas nos géis dos dois grupos, com diferentes pesos moleculares. As atividades antioxidante séricas de algumas enzimas tiveram diferenças estatísticas significativas. O oxido nítrico (NO) sérico teve diferença significativa entre os grupos (0,0003), tendo maior atividade no grupo sadio em comparação com o grupo doente. Entre os resultados promissórios nosso trabalho esteve a diminuição dos níveis de a Apo A1, no grupo doente quando comparado com o grupo sadio, o qual é um indicativo de um processo inflamatório maior no grupo com endometrite, devido a esta proteína de fase aguda (PFA), ser considerada uma PFA negativa. Pode-se concluir que os resultados batem os o esperado. Palavras-chave: Inflamação. Haptoglobina. Transferrina. Ceruloplasmina. Espécies reativas de oxigênio.
To the 100th anniversary of the birth of academician V.A. Nasonova. Osteoporosis: Yesterday, today, tomorrow
Authors: Toroptsova N. V. , Nikitinskaya O. A. , Nasonov E. L.
Published: June 2023

Osteoporosis (OP) is the most common bone disorder associated with an increase bone fragility and a high fracture risk, which can be an isolated condition or a comorbidity of immuno-inflammatory rheumatic diseases. A great contribution to the study of OP in the Russian Federation was made by V.A. Nasonova, L.I. Benevolenskaya and scientific researchers of the Institute of Rheumatology. The article presents the main achievements that have occurred over the past 30 years in the development of this problem in our country and abroad, and the perspectives of osteoporosis treatment.
Updated American College of Rheumatology/American Association of Hip and Knee Surgeons guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty 2022
Authors: Amirjanova V. N. , Makarov M. A. , Karateev A. E. , Khramov A. E. , Maglevaniy S. V. , Rozov A. V. , Nesterenko V. A. , Nasonov E. L.
Published: June 2023

The article presents updated guidelines developed by the American College of Rheumatology and the American Association of Hip and Knee Surgeons on the perioperative treatment of patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, juvenile idiopathic arthritis and systemic lupus erythematosus undergoing elective total hip or total knee arthroplasty. The perioperative use of anti-rheumatic drug therapy, including traditional disease-modi fying antirheumatic drugs, biologic agents, targeted synthetic small-molecule drugs and glucocorticoids. All recommendations are conditional and based on the results of retrospective clinical studies, which should be taken into account in decisionmaking when choosing perioperative antirheumatic therapy.
Rheumatoid arthritis as a clinical and immunological syndrome: focus on the seronegative subtype of the disease
Authors: Nasonov E. L. , Avdeeva A. S. , Dibrov D. A.
Published: June 2023

Rheumatoid arthritis (RA) is the most common immune mediated (autoimmune) rheumatic disease, manifested by chronic erosive arthritis and systemic internal organ damage. Currently, RA is considered as a syndrome characterized by clinical and pathogenetic heterogeneity associated with a variety of mechanisms of pathological activation of innate and acquired immunity, determining the variability of the course and outcome of the inflammatory process and effectiveness of therapy. Based on the detection or absence of rheumatoid factor (RF) IgM and antibodies to cyclic citrullinated peptides (ACCP), RA can be conventionally divided into two subtypes (phenotypes): seropositive RA and seronegative RA, but thanks to improvement of laboratory diagnostic methods the spectrum of autoantibodies detected in RA has increased significantly. Diagnosis of seronegative RA based on classification (rather than diagnostic) criteria can be difficult, especially in the early stages of the disease, and the diagnosis is made only during long-term follow-up of patients. It complicates the timely prescription of adequate anti-inflammatory therapy. This article summarizes the data on genetic predisposition, immunopathogenesis, biomarkers, clinical spectrum, instrumental diagnosis and pharmacotherapy of seronegative RA.
Systemic lupus erythematosus and pregnancy: Before gestation, during and after childbirth
Authors: Reshetnyak T. M. , Kosheleva N. M. , Nasonov E. L.
Published: June 2023

Systemic lupus erythematosus (SLE) is a disease of women of reproductive age. Up to a certain time, pregnancy was contraindicated in patients with SLE, improving the management of the disease itself (monitoring), as well as understanding the safety of drugs make pregnancy possible for most patients with SLE. Careful pregnancy planning is crucial when the disease is well controlled with pregnancy-compatible medications. This is also facilitated by the management of patients jointly by doctors of different specialties (rheumatologist, neurologist, endocrinologist, etc.) with obstetricians. The article discusses the achievements of managing women with SLE during pregnancy planning, during pregnancy and after delivery.
FRAX-based intervention thresholds for men in the Russian Federation: Expert consensus of the Russian association on osteoporosis
Authors: Gladkova E. N. , Nikitinskaya O. A. , Skripnikova I. A. , Myagkova M. A. , Baranova I. A. , Belaya Zh. E. , Belova K. Yu. , Evstigneeva L. P. , Ershova O. B. , Zavodovskii B. V. , Kosmatova O. V. , Otteva E. N. , Polyakova Yu. V. , Sivordova L. E. , Suleymanova A. K. , Toroptsova N. V. , Tsoriev T. T. , Lesnyak O. M.
Published: June 2023

According to the European guidelines for osteoporosis, the same FRAX intervention threshold is suggested for men as for women. At the same time, in the Russian Federation, according to research data, an extremely low proportion of identified men who are subject to the initiation of osteoporosis therapy. The female intervention threshold identifies only 1.1 to 4% of men for treatment. Aim – to develop and evaluate various options for the intervention threshold using the FRAX calculator for men in the Russian Federation and adopt the most acceptable intervention threshold by consensus. Material and methods. Delphi voting was conducted among 18 Russian experts who have publications and personal reports about their experience with the FRAX calculator. For discussion, 5 intervention threshold options with the corresponding rationale based on the literature reference were presented, as well as the proportion of men of different ages to be initiated in each of the options (based on several Russian population-based studies). Anonymous voting was carried out using the Delphi method with questionnaire placed in the Google form. It was proposed to evaluate all options for intervention thresholds on a 9-point Likert scale. Consensus was considered reached if the intervention threshold reached a Likert score of 7 or more points in 80% or more of the experts. The rating of each intervention threshold option was expressed as mean and standard deviations. Results. In the first round of voting, the maximum rating and percentage of agreement is reached for the 9% fixed interference threshold option based on the FRAX calculation. The rating was 7.72±1.6 points, the percentage of experts’ agreement was 88.9%. A fixed threshold of 9% determined 13–19.5% of men aged 50 years and older to be treated for osteoporosis, while their proportion increased to 26–38% at the age of 85 years and older. Conclusion. The consensus of experts of the Russian association on osteoporosis suggests initiating treatment of osteoporosis in Russian men with a 10-year probability of major osteoporotic fractures according to FRAX of 9% or higher.
Ovarian reserve in patients with systemic sclerosis
Authors: Goloeva R. G. , Ananyeva L. P. , Alekberova Z. S. , Glukhova S. I. , Cherkasova M. V. , Garzanova L. A. , Koneva O. A. , Reshetnyak T. M.
Published: June 2023

Objective. To evaluate the ovarian reserve in women with systemic sclerosis (SSc) and to analyze the relationship of the concentration of anti-Müllerian hormone (AMH) with the main manifestations of the disease and therapy. Material and methods. The study included 74 SSc patients aged 18 to 40 years; the control group consisted of 32 healthy women, matched by age. The concentration of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol (E2) and testosterone was determined by enzyme immunoassay (ELISA), AMH quantitatively using standard chemiluminescent analysis on paramagnetic particles in blood serum. The AMG level of 1.0– 10.6 ng/ml was taken as normative values. Values <1.0 were regarded as a decrease in ovarian reserve. Results. In patients with SSD, the levels of AMH and testosterone were significantly lower than 1.4 [0.5; 2.3] and 0.45 [0.2; 0.96], respectively, versus 2.4 [1.8; 3.3] (p=0.002) and 1.6 [0.97; 2.5] (p=0.0001) in the control. The concentration of prolactin and E2 was recorded higher with SSDs – 22.23 [14.08; 31.18] and 140.2 [102.43; 179.74], respectively, against 10.2 [7.11; 16.68] (p=0.000002) and 95.3 [64.50; 130.0] (p=0.002) in the control. A decrease in the ovarian reserve by the level of AMH was significantly more often detected in patients with SSD in 43% versus 9.4% in the control (p=0.002). The risk of AMH reduction in patients with SSD was 7 times higher compared to the control (OR=7.030; 95% CI: 1.97–25.11). The levels of the hormones studied were comparable in patients with low and normal ovarian reserve. Diffuse form (46.9%) and subacute course of the disease (53.1%) were more often detected in patients with SSD and with low ovarian reserve compared to those with normal ovarian reserve (23.8% (p=0.033); 23.4% (p=0.004)). The frequency of organ lesions of SSDs, immunological disorders, inflammatory markers, and the lipid spectrum in the groups did not differ depending on the level of AMH. There were also no differences in the regimens and doses of treatment with basic anti-inflammatory drugs and glucocorticoids. Menstrual cycle disorders were noted by 31% of patients with SSD versus 6.2% in the control (p=0.004). Premature ovarian insufficiency (POI) was detected in 6.8% of patients with SSD and none in the control group (p=0.02). Patients with SSD and POI did not differ in age, duration of illness, clinical manifestations and therapy of them without POI.Conclusion. The concentration of AMH and testosterone was significantly lower in patients with. A decrease in ovarian reserve was significantly more often detected in women with SSs. Low ovarian reserve was more often detected in patients with diffuse form and subacute course of the disease. POI was more often observed in the group of SSc.
Susac syndrome: The effectiveness of Rituximab monotherapy
Authors: Beketova T. V.
Published: June 2023

Susac syndrome (SS) or retino-cochleo-cerebral vasculopathy is an extremely rare, severe, and potentially disabling condition. Underlying occlusive microangiopathy in SS is clinically characterized by the triad of encephalopathy, sensorineural hearing loss and branch retinal arterial occlusion. SS therapy envisages simultaneous use of high doses of glucocorticoids, intravenous immunoglobulins, cyclophosphamide and rituximab (RTХ). This article presents a case of remitting-relapsing slow-progressive SS with typical clinical manifestations demonstrating successful treatment SS with RTХ monotherapy; it also discuss the focus of RTХ monotherapy should be targeted at SS cases with contraindications for glucocorticoids and cytostatics use, slow-progressive SS or at early stages.
Mucinous Cytadenoma of the Pancreas: A Case Report with Review of the Literature
Authors:   Department of Visceral Surgery, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Morocco, Yousra Ouhammou
Published: June 2023

Mucinous cystadenomas are a rare entity of cystic lesions of the pancreas, often discovered incidentally and posing a preoperative diagnostic challenge. Women are more often affected than men and these lesions are often asymptomatic, discovered by imaging and biological means. Benign pancreatic mucinous cystadenomas have a very high cure rate with a reduced rate of degeneration. Simple excision of benign pancreatic cysts is considered safe and effective with a very low recurrence rate.
Identification of Circuits in Ventricular Tachycardia Ablation in Hypertrophic Cardiomyopathy: A Case Report
Authors:   Department of Electrophysiology, Ignacio Chavez National institute of Cardiology, Mexico City, Mexico, Gomez-Flores Jorge R
Published: June 2023

Catheter ablation of ventricular tachycardia (VT) in structural heart disease is a useful strategy to reduce the discharges of implantable cardioverterdefibrillators (ICDs) and improve patient survival. We present the case of a 30-year-old female, with hypertrophic cardiomyopathy, carrier of ICD as primary prevention, who presented to the emergency department with an electrical storm and multiple shocks (Figure 1), which is why she was taken to catheter ablation. In the procedure, two tachycardia circuits were identified, and radiofrequency was applied.
Tecnología y Comunicación en Educación: Fundamentos para su discusión
Authors: Carpio Vera Dinora Alexandra , Intriago Alcívar Glenda Cecibel , Mendiburu Rojas Augusto Franklin , Arellano Romero Johanna Ivette
Published: June 2023

Sin duda, la virtualidad llegó al mundo educativo con más fuerza que nunca; y lo hizo ¡para quedarse! Por ello, la realización de esta publicación titulada: Tecnología y comunicación en educación: Fundamentos para su discusión; resulta en un documento muy pertinente porque incita al debate permanente, en el ámbito educativo, sobre las implicaciones al incorporar las Tecnologías de Información y Comunicación en el hecho didáctico potenciadas, fundamentalmente, por el confinamiento en virtud de la declaración de pandemia que, a pesar de le nueva normalidad, está aún vigente. 

Desde esta perspectiva, se presenta la Dra. Dinora Alexandra Carpio Vera; ofreciendo una visión sobre las Apps, como sistema de gestión académico-administrativo en la educación superior. Y es que el Docente del siglo XXI, no solo se destaca por el hecho mismo de la docencia, sino también en el ejercicio gerencial; dado el perfil organizacional que poseen las instituciones educativas y la necesaria optimización de sus procesos, que forman parte de las condiciones para el fortalecimiento del egresado.  

Por supuesto, el hecho didáctico; promovido por la propia la naturaleza del ejercicio de la docencia; se ve influenciado por las plataformas digitales, como recurso académico-comunicacional en la educación superior; de lo cual, nos diserta la Dra. Glenda Cecibel Intriago Alcívar. En este sentido, el trabajo es significativo; producto de la dinámica cambiante y permanente de las plataformas no solo educativas, sino además de una gran diversidad de opciones, sobre todo recreativas, a las cuales el sector educativo se enfrenta, para moldear el desarrollo integral del ciudadano. 

Como ya se mencionó, la situación pandémica que, aun, afecta a la globalidad; es analizada por el Dr. Augusto Franklin Mendiburu Rojas; desde la perspectiva de su incidencia en el contexto educativo, mediante su disertación sobre: Educación superior, virtualización en el marco de la pandemia covid-19.

 Finalmente, la Máster Johanna Ivette Arellano Romero, nos realiza una serie de reflexiones en su apartado titulado: educación superior y las tecnologías de la información y comunicación; sobre la importancia del estudio de este fenómeno y que permite inferir grandes desafíos para los docentes y gerentes educativos en su incorporación al hecho educativo y que permita apuntar a la calidad y excelencia educativa.

 Estos aportes, sin lugar a duda, ponen de manifiesto el compromiso de los educadores; en pos del fortalecimiento de la educación y su contribución al desarrollo global.