bluuebunny/crossref_metadata_2025 huggingface dataset:
Nonstationary local slope estimation via forward-backward space derivative calculation
Authors: Chen Wei , Wang Hang , Yang Liuqing , Liu Xingye , Chen Yangkang
Published: September 2021

The local slope estimated from seismic images has a variety of meaningful applications. Slope estimation based on the plane-wave destruction (PWD) method is a widely accepted technique in the seismic community. However, the PWD method suffers from sensitivity to noise in the seismic data. We have developed an improved slope estimation method based on the PWD theory that is more robust in the presence of strong random noise. The PWD operator derived in the Z-transform domain contains a phase-shift operator in space corresponding to the calculation of the first-order derivative of the wavefield in the space domain. The first-order derivative is discretized based on a forward finite difference in the traditional PWD method, which lacks the constraint from the backward direction. We have developed an improved method by discretizing the first-order space derivative based on an averaged forward-backward finite-difference calculation. The forward-backward space derivative calculation makes the space-domain first-order derivative more accurate and better at antinoise because it takes more space grids for the derivative calculation. In addition, we introduce nonstationary smoothing to regularize the slope estimation and to make it even more robust to noise. We determine the performance of the new slope estimation method with several synthetic and field data examples in different applications, including 2D/3D structural filtering, structure-oriented deblending, and horizon tracking.
Patients' Expectations of Benefits From Large-Panel Genomic Tumor Testing in Rural Community Oncology Practices
Authors: Anderson Eric C. , DiPalazzo John , Edelman Emily , Helbig Petra , Reed Kate , Miesfeldt Susan , Thomas Christian , Lucas F. Lee , Fenton Anny T. H. R. , Antov Andrey , Hall Michael J. , Roberts J. Scott , Rueter Jens , Han Paul K. J. ,   MCGI Working Group
Published: September 2021

PURPOSE

Large-panel genomic tumor testing (GTT) is an emerging technology that promises to make cancer treatment more precise. Because GTT is novel and complex, patients may have unrealistic expectations and limited knowledge of its benefits. These problems may limit the clinical value of GTT, but their prevalence and associated factors have not been explored.

METHODS

Patients with cancer enrolled in a large initiative to disseminate GTT in community oncology practices completed surveys assessing their expectations, knowledge, and attitudes about GTT. The study sample (N = 1,139) consisted of patients with a range of cancer types (22% gynecologic, 14% lung, 10% colon, 10% breast, and 46% other malignancies) and cancer stages (4% stage I, 3% stage II, 15% stage III, and 74% stage IV). Mean age was 64 years (standard deviation = 11); 668 (59%) were women; 71% had no college degree; 57% came from households with less than $50,000 US dollars household income; and 73% lived in a rural area.

RESULTS

Generally, patients had high expectations that they would benefit from GTT (M = 2.81 on 0-4 scale) and positive attitudes toward it (M = 2.98 on 0-4 scale). Patients also had relatively poor knowledge about GTT (48% correct answers on an objective test of GTT knowledge). Greater expectations for GTT were associated with lower knowledge (b = –0.46; P < .001), more positive attitudes (b = 0.40; P < .001), and lower education (b = –0.53; P < .001).

CONCLUSION

This research suggests patients have high expectations that they will benefit from GTT, which is associated with low knowledge, positive attitudes, and low education. More research is needed to understand the concordance between expectations and actual clinical outcomes.
Indirect Subjects
Authors: Brown Matthew H.
Published: September 2021

In Indirect Subjects, Matthew H. Brown analyzes the content of the prolific Nigerian film industry's mostly direct-to-video movies alongside local practices of production and circulation to show how screen media play spatial roles in global power relations. Scrutinizing the deep structural and aesthetic relationship between Nollywood, as the industry is known, and Nigerian state television, Brown tracks how several Nollywood films, in ways similar to both state television programs and colonial cinema productions, invite local spectators to experience liberal capitalism not only as a form of exploitation but as a set of expectations about the future. This mode of address, which Brown refers to as “periliberalism,” sustains global power imbalances by locating viewers within liberalism but distancing them from its processes and benefits. Locating the wellspring of this hypocrisy in the British Empire's practice of indirect rule, Brown contends that culture industries like Nollywood can sustain capitalism by isolating ordinary African people, whose labor and consumption fuel it, from its exclusive privileges.
Characterization of the Binding of Adenosine-5′-monophosphate to a µ-Type Alkoxide-Linked Dinuclear Zinc(II) Complex in Crystal and Solution State
Authors: Kinoshita-Kikuta Emiko , Ichimaru Yoshimi , Yamano Yoshi , Kato Koichi , Kurosaki Hiromasa , Kinoshita Eiji , Koike Tohru
Published: September 2021

The binding of adenosine-5′-monophosphate dianion (AMP2−) to a µ-type alkoxide-linked dinuclear zinc(II) complex (Zn2L3+) has been studied {L = alkoxide form of 1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol}. X-ray crystallography and potentiometric pH titration have been used to decipher the structure of 1:1 AMP2−-bound Zn2L3+ complex in crystal and solution state. The crystal analysis of the AMP2−–Zn2L3+ complex demonstrated that the 5′-phosphomonoester dianion binds to the two zinc(II) ions in a µ-η2 bridge coordination mode. Each zinc(II) ion has a distorted trigonal-bipyramidal coordination environment with five donor atoms: two pyridine N, alkoxide O−, tertiary amine N, and phosphate O−. In contrast, 1:1 NO3−-bound Zn2L3+ complex showed that the nitrate anion binds to one of the zinc(II) ions in a monodentate coordination mode and a water molecule coordinates to the other zinc(II) ion. The pH titration study disclosed that the AMP2−–Zn2L3+ complex is remarkably stable in a wide pH range between 5 and 9. The dissociation constant Kd (= [AMP2−][Zn2L3+]/[AMP2−–Zn2L3+]) is an extremely low value of 4.0 nM at 25 °C and I = 0.10 M (NaNO3) in aqueous solution.
Design and prototype of TOMO: an app for improving drug resistant TB treatment adherence
Authors: Fuad Anis , Herwanto Guntur Budi , Pertiwi Ariani Arista Putri , Wahyuningtias Siska Dian , Harsini Harsini , Maula Ahmad Watsiq , Putri Diyah Utami Kusumaning , Probandari Ari , Ahmad Riris Andono
Published: September 2021

Background: Drug resistance and multi drugs tuberculosis (DR/MDR-TB) are associated with patients' low adherence to undergoing complex treatment. Driven by the increasing use and penetration of a smartphone and the End of TB Strategy that seeks for digital health solution, Center for Tropical Medicine Universitas Gadjah Mada has developed TOMO, an Android-based app for improving medication adherence in MDR-TB.

Objective: This paper aims to present the sequential steps to develop the app, its general architecture, and its functionalities.

Methods: It is a design thinking process involving two MDR-TB referral centers, district health offices, primary health centers, and MDR-TB patients in Central Java and Yogyakarta, Indonesia. We adopted the Principles for Digital Development to develop and design the app. MDR-TB treatment guideline from the Indonesian Ministry of Health was used to develop functionalities of the app for improving adherence.   

Results: TOMO app could be used by patients, primary health centers, clinical teams, and case managers. The app prototype features include adverse event records and reports, medication-taking reminders, and communication between the patient and the TB-MDR case manager. We have successfully tested the functionalities based on four use cases: patients with high adherence, patients with low adherence, patients with adverse events, and patients following treatment in the primary health center without any visit to the MDR-TB center.       

Conclusion: TOMO app has contributed to the limited body of literature on improving TB-MDR adherence with digital health intervention, especially using a health app. The app has been tested using four scenarios. We will follow up with usability testing before implementing the app in a real setting.
COVID-19: Identifying countries with indicators of success in responding to the outbreak
Authors: Kennedy David S. , Vu VK , Ritchie Hannah , Bartlein Rebecca , Rothschild Oliver , Bausch Daniel G. , Roser Max , Seale Anna C.
Published: September 2021

Background: In designing responses to the COVID-19 pandemic, it is critical to understand what has already worked well. We aimed to identify countries with emerging success stories from whom policymakers might draw important lessons. 

Methods: We developed a process to first include countries with large enough populations that results were unlikely to be due to chance, that had sufficient cases for response mechanisms to be tested, and that shared the necessary publicly available data. Within these countries, we looked at indicators suggesting success in terms of detecting disease, containing the outbreak, and treating those who were unwell. To support comparability, we measured indicators per capita (per million) and across time. We then used the indicators to identify three countries with emerging success stories to include some diversity in global region, population demographics and form of government.

Results: We identified 66 countries that met our inclusion criteria on 18th May 2020. Several of these countries had indicators of success against the set indicators at different times in the outbreak. Vietnam had high levels of testing and successful containment with no deaths reported. South Korea had high levels of testing early in the outbreak, supporting containment. Germany had high levels of sustained testing and slower increases in cases and deaths than seen in other comparable settings.

Conclusions: At the time of our assessment, Vietnam and South Korea were able to contain the outbreak of COVID-19 and avoid the exponential growth in cases seen elsewhere. Germany had more cases and deaths, but was nevertheless able to contain and mitigate the outbreak. Despite the many limitations to the data currently available, looking at comparative data can help identify countries from whom we can draw lessons, so that countries can inform and adapt their strategies for success in response to COVID-19.
ВЛИЯНИЕ ПОГОДНЫХ УСЛОВИЙ НА УРОЖАЙНОСТЬ ЯРОВОГО ЯЧМЕНЯ В ЗОНЕ ВЛИЯНИЯ ЛЕСНОЙ ПОЛОСЫ
Authors: Seminchenko Elena V.
Published: September 2021

Обоснование. В статье изложены материалы исследований по влиянию полезащитных лесных полос на рост и развитие ярового ячменя. Объектом исследований является яровой ячмень сорта Медикум 139. Исследования проводились в Землепользовании «Городищенское», кадастровый номер 34:03:000000:6.
Цель работы – обосновать роль осадков и других факторов для формирования урожая ярового ячменя под влиянием лесной полосы.
Материалы и методы. Учет урожайности определялся на площадках 1 м2 на удалении соответственно 5, 10, 30Н. Контролем служил открытый участок без лесной полосы. Снопы отбирали в трехкратной повторности, замет обмолачивали. Полученное зерно взвешивали и проводили пересчет урожайности на 1 га. Урожай зерна, полученный при взвешивании, приводился к 14%-й влажности и 100%-й частоте. Длина стебля, количество колосков и зерен в колосе определялись визуально. Масса 1000 зерен определялась на технико-химических весах.
Результаты. Анализ данных показал, что запасы продуктивной влаги на межполосной клетке распределены неравномерно. В условиях агролесоландшафта наибольший весенний влагозапас накапливается в зоне от 5Н до 15Н от полезащитных лесных полос. Исследования показали, низкий ГТК приходится на летний период (июль-август) практически во все годы исследований. Обеспеченным по продуктивности накоплению осадков был 2016 год, где ГТК составил 0,7, в остальные годы засушливый 0,3-0,5. Структурный анализ ярового ячменя показал, что наибольшая урожайность была на расстоянии 10Н и состалила у ярового ячменя – 1,4 т/га. В статье приведены результаты корреляционно-регрессивного анализа полученных данных по взаимосвязи урожая ярового ячменя с составляющими факторами (осадки, запасы почвенной влаги), влияющими на урожайность ярового ячменя за 2016–2020 годы. Получены результаты, приведенные в графической корреляции, и обоснована закономерность.
Заключение. Результаты исследования свидетельствуют о важной роли лесных полос. Областью применения рекомендаций является зона почв Нижнего Поволжья.
ЭФФЕКТЫ ДЕЙСТВИЯ ФИКОБИЛИПРОТЕИНОВ ARTHROSPIRA PLATENSIS (NORDSTEDT) GOMONT В РАСТИТЕЛЬНЫХ ТКАНЯХ: АНТИОКСИДАНТНАЯ АКТИВНОСТЬ В ГЛЮКОЗООКСИДАЗНОЙ ТЕСТ-СИСТЕМЕ И РАЗОБЩЕНИЕ ОКИСЛЕНИЯ И ФОСФОРИЛИРОВАНИЯ В МИТОХОНДРИЯХ
Authors: Stepanov Alexey V. , Aksenova Alisa A. , Polyakova Elizaveta A. , Fedoseeva Irina V. , Grabelnykh Olga I. , Gevorgiz Ruslan G.
Published: September 2021

Обоснование. Цианобактерия Arthrospira (Spirulina) platensis (спирулина) обладает уникальным биохимическим составом и находит широкое применение в различных сферах, в том числе в медицине и сельском хозяйстве. Основные фикобилипротеины (ФБП) спирулины – С-фикоцианин и аллофикоцианин защищают клетки животных от окислительного стресса и дисфункции митохондрий. В то же время мало сведений об антиоксидантных свойствах ФБП в растительной клетке и их влиянии на биоэнергетические параметры митохондрий растений.
Цель. Целью данной работы было изучение влияния экстракта ФБП A. platensis на глюкозооксидазную активность и функционирование митохондрий картофеля.
Материалы и методы. ФБП выделяли из сырой биомассы A. platensis (Nordstedt) Gomont (штамм IBSS–31) с помощью холодной экстракции и осаждения ацетоном. Белковый экстракт с высокой долей С-фикоцианина использовали в концентрациях 0,025 – 0,25 мг/мл. Об антиоксидантных свойствах ФБП судили по ингибированию глюкозооксидазной активности экстрактов картофеля с повышенной экспрессией гена GOX. Окислительную и фосфорилирующую активность митохондрий в присутствии ФБП оценивали полярографическим методом. Статистическую обработку данных осуществляли с помощью SigmaPlot v. 14.0.
Результаты. Глюкозооксидазный тест выявил антиоксидантную активность экстракта ФБП, ярко выраженную при концентрации белка 0,25 мг/мл. В этой же концентрации экстракт вызывал разобщение процессов окисления и фосфорилирования в митохондриях картофеля при окислении сукцината, связанное с повышением скорости дыхания в состоянии 4 и снижением коэффициента дыхательного контроля.
Заключение. Таким образом, фикобилипротеины A. platensis концентрационно-зависимым образом снижают генерацию пероксида водорода в глюкозооксидазной тест-системе и разобщают процессы окисления и фосфорилирования митохондрий растений.
ПСИХОЛОГИЧЕСКОЕ ЗДОРОВЬЕ СПОРТСМЕНОВ В ПЕРИОД ПАНДЕМИИ COVID-2019
Authors: Kislyakov Pavel A. , Belov Mikhail S. , Konstantinova Nataliya P.
Published: September 2021

Обоснование. Массовая самоизоляция в период пандемии COVID-19 оказала существенное влияние на спортивную деятельность, и как следствие, на психологическое здоровье спортсменов. Основные последствия для психологического здоровья спортсменов связаны в первую очередь с психосоматическими и психоэмоциональными расстройствами.
Цель исследования состояла в выявлении особенностей психологического здоровья спортсменов в период пандемии COVID-2019.
Материалы и методы. Выборку составили 419 спортсменов в возрасте от 18 до 30 лет, проживающих в различных регионах России. Исследование проводилось с использованием специально разработанной анкеты, включающей вопросы об особенностях организации тренировочного процесса в период пандемии, о дальнейших спортивных планах, о психосоматических и психоэмоциональных особенностях, вызванных вследствие отмены спортивных тренировок и соревнований. Также использовалась стандартизированная методика «Самочувствие, активность, настроение – САН» (В.А. Доскин, Н.А. Лаврентьева, В.Б. Шарай и М.П. Мирошников).
Результаты. Проведенное исследование выявило закономерность, состоящую в том, что поддержка оптимальной физической формы в период пандемии COVID-19 позволяет предупреждать негативные психосоматические и психоэмоциональные проявления, обеспечивая субъективное ощущение благоприятного физиологического и психологического состояния. Адаптивный копинг принятия спортсменами ситуации и самоконтроля прямо коррелирует с поддержкой оптимальной физической формы в период пандемии COVID-19 и, как следствие, с позитивными спортивными планами.
Заключение. Полученные результаты подтверждают, что поддержание регулярной физической активности является важной профилактической стратегией для физического и психологического здоровья во время вынужденной самоизоляции.
Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension
Authors: Hnizdyukh Roman Volodymyrovych , Shmanko Volodymyr Vasylovych
Published: September 2021

The aim of this work is to determine specificities of blood pressure (BP) numbers during the day depending on polymorphism of the A1166C-gene of angiotensin II receptor type I and T786C-promoter of the endothelial NO-synthase gene among residents of Ternopil region afflicted with essential arterial hypertension.We have examined 86 patients with arterial hypertension who were treated and examined in the therapeutic department of the Central District Hospital in Kozova, aged from 45 to 76 years. All patients were measured for body weight and height, office blood pressure; also they were checked by Holter monitoring and electrocardiography (ECG), as well as examined for polymorphism of endothelial NO synthase genes and angiotensin II type 1 receptor genes. Statistical processing of the obtained data was performed with the help of the analytics software package including Statistica 8.0 (StatSoft Inc., USA) and Microsoft Office Excel-2003.The research revealed that patients with CC genotype A1166C-gene of angiotensin II receptor of the first type had a significantly higher level of systolic blood pressure (SBP) and diastolic blood pressure (DBP) – average numbers per 24 hours, day and night – compared to patients with genotype AA(p<0,05). Hereby, no significant distinctions in blood pressure variability were found.Patients with CC of the T786C promoter of the eNOs gene had higher SBP and DBP values at all times of the day compared to individuals with the TT genotype (p <0.05). Increased levels of variability of DBP during the day, as well as SBP and DBP at night, were observed among patients with CC genotype, as compared with the control group (p <0.05).Among patients with C-allele of both studied genes, there’s a high frequency of circadian rhythm disorders with predominance of the “non-dippers” pathological type.
COVID 19 and vaccine safety
Authors: Raczkiewicz Przemysław , Zaremba Bartłomiej , Śmiech Natalia , Nowakowska Katarzyna , Lewkowicz Martyna , Trojnar Marcin
Published: September 2021

Introduction. COVID-19 disease, caused by SARS-CoV-2 virus, has been recognised as pandemic by WHO since March 11, 2020. It has been estimated that the disease is responsible for the death of 3.11 million people worldwide. Although several therapeutic agents have been evaluated for the treatment of COVID-19 disease, vaccines are considered to be the safest form of protecting patients against COVID-19. The safety of each vaccine is vital to control the pandemic. Due to the fact that vaccines have been launched quite recently and their production technologies are different, the safety of each preparation should be looked into separately. Nucleic acids do not trigger such a strong immune response on their own as viral vectors and that is why mRNA vaccines seem to be the safest types of vaccines. In December 2020, after a year since detecting the first case of by SARS-CoV-2 infection in humans, the first anti-COVID-19 vaccine became available.Objective. The purpose of this review was to present the literature data and the latest recommendations on risks related with COVID-19 vaccines.Method. The latest literature was reviewed based on PubMed and Google Scholar databases, using the following keywords: COVID-19; vaccines; safetyConclusions. Anti-COVID-19 vaccines seem not to cause many adverse events and side effects such as fever, chills, muscle pain, headache and fatigue. These are not serious and subside after taking over-the-counter pain relievers. Currently, there are no information on safety and efficacy of vaccines in pregnant and breast-feeding women, international expert recommendations leave the decision about vaccination with a woman, who should previously consult the benefits and risks involved with her doctor.
Anthropometric and biomotor factors that determine the ability of field tennis service
Authors: Jannah Munifatul , Hidayatullah M Furqon , Syaifullah Rony
Published: September 2021

This study aims to analyze the Anthropometric and Biomotor Factors that Determine the Ability of Field Tennis Service on Achievement Development Students of FKOR UNS Surakarta. The method used in this study is a quantitative research approach using a confirmatory factor analysis design. Data were processed and analyzed using SPSS software version 22 and factor analysis using the Kaiser-Meyer-Olkin and Bartlett's Test. The population in this study were the 25 students of FKOR UNS tennis achievement coaching students. The sampling technique in this study used a total sampling technique. Data collection techniques using tests and measurements. Anthropometric factors that determine the ability to serve in tennis are weight with a value of 0.695, height with a value of 0.661 and arm length with a value of 0.628. The biomotor factors that determine the ability to serve in tennis are arm muscle power with a value of 0.863 and eye-hand coordination with a value of 0.653. Based on the results of the second analysis, it was found that the five variables had communalities values > 0.5. So it can be concluded that the greater the value of the communalities of these factors will provide benefits to students in coaching tennis achievements in serving tennis.Keywords: Anthropometry, Biomotor, Service Ability, Tennis
Dynamics of changes in the structural components of the mucosa and cartilage of the larynx of rats at the end of 42 days of experimental opioid exposure and after 56 days with opioid withdrawal
Authors: Ivasivka Khrystyna
Published: September 2021

In our work we aimed to study the pathomorphological manifestations among the structural components of the laryngeal mucosa and cartilage in the later stages of the experimental opioid effect. This goal was achieved through the use of histological techniques to visualize the structural components of the laryngeal mucosa and cartilage. Histological sections with a thickness of 5 -7 mm were made. Histological specimens were prepared according to conventional methods using the dye hematoxylin, eosin, azan according to the method of Heidenhain, PAS-reaction according to Mc-Manus and Alcian blue according to Steedman. Microscopic examinations and photographing of the preparations were performed using an MBI-1 microscope and a Nicon D 3100 digital camera.At the end of 42 days of experimental exposure, the epithelial layer of the epiglottis was inhomogeneously thickened, with excessive accumulation on its pharyngeal and apical part of the stratum corneum. Individual epitheliocytes of the pharyngeal part of the epiglottis underwent necrotic changes, the horny substance loosened in places. On the pharyngeal surface of the mucous membrane found a small amount of mucus with impurities of erythrocytes. Dyscirculatory processes were also registered in the animals of the experimental group. In particular, dilatation and overflow of erythrocytes of vessels of own plate of a mucous membrane of an epiglottis, and also polymorphonuclear infiltration of own plate of a mucous membrane were observed.
Varieties of the state of exchange of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) and their immune accompaniment at rats
Authors: Kuchma Igor , Flyunt Igor-Severyn , Ruzhylo Sofiya , Zukow Walery , Bilas Volodymyra , Popovych Igor
Published: September 2021

Background. Earlier we found that even in intact rats, certain parameters of nitrogenous metabolism and immunity fluctuate in a fairly wide range, which further expands in cases of prolonged water loads. The links between the individual parameters of metabolism and immunity were revealed. Based on this, the aim of this study was to create groups that are homogeneous in the parameters of nitrogenous metabolism, followed by a search for the characteristic parameters of immunity. Material and methods. Experiment was performed on 60 healthy female Wistar rats, both intact and loaded with different mineral waters. The plasma levels and urinary excretion of the nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) were determined. Immune status was assessed by thymocytogram, splenocytogram, blood leukocytogram and immunocytogram, as well as by phagocytosis parameters of blood neutrophils and monocytes. Results. The characteristic features of the members of the most numerous (29 animals) of the first cluster are moderately elevated plasma urea and upper borderline creatinineemia in combination with lower borderline uricemia. In members of the third cluster (22 animals), all seven parameters are in the range of normal. In contrast, rats of the second cluster (n=9) were found to have significantly increased levels of urea and creatinine excretion, as well as uricemia. Each cluster is accompanied by a specific constellation of immune parameters. The overall accuracy of the classification is 95%. Conclusion. The variety of states of exchange of nitrogenous metabolites is accompanied by specific constellations of immune parameters.
Diagnostic and genetic markers associated with pulmonary tuberculosis in HIV-infected individuals
Authors: Chemych Mykola , Yanchuk Svitlana , Zhuk Kateryna
Published: September 2021

An important aspect of monitoring, further timely and effective treatment of HIV-TB coinfection is timely and correct diagnosis based on comprehensive clinical, laboratory and instrumental studies. Many factors play a role in the development of tuberculosis in HIV-infected people, but the key and quite important elements are the study of genetic markers and biomarkers of inflammation. A number of studies have been carried out on inflammatory markers, but IL-6, INF-γ, MIG, CRP, IL-18 remain relevant and insufficiently studied in coinfection. A comprehensive study of them will be important in the screening of HIV-TB coinfection). Determining the presence of (SNP) rs4331426 located in chromosome 18q11.2 in HIV-infected and AIDS patients will solve the issue of predisposition to the development of tuberculosis in the early stages of HIV infection and contribute to the development of further tactics of patients treatment and management.
Anthropometric indicators of obesity. Are the new indicators a better predictor of body fat content than BMI?
Authors: Walczyk Teresa
Published: September 2021

Anthropometric measurements are widely used in medicine, scientific research, but also in specialist medical care. Their proper use provides valuable information about the nutritional status, the adipose tissue and even the risk of comorbidities. Numerous scientific works question the usefulness of the BMI (body mass index), which is only an indirect measure of obesity. It does not take into account information on gender and age, and does not provide an answer on the distribution of body fat. Misclassification can result in serious deviations in the estimation of obesity-related effects. Therefore, the aim of this study is to present five new anthropometric obesity indicators as an alternative to BMI.In response to the dramatically growing problem of overweight and obesity, further exacerbated by the necessary restrictions related to the COVID-19 pandemic, it is necessary to search for precise, yet simple tools for assessing body composition that can be routinely used by individuals but also for population studies. Based on the literature review, five frequently described indicators were selected: Relative Fat Mass (RFM), A Body Shape Index (ABSI), Body Adiposity Index (BAI), Body Roundness Index (BRI) and CUN-BAE. Application possibilities and their effectiveness for the estimation of adipose tissue content and the risk of coexisting diseases are presented.Growing number of authors confirm the validity of using indicators such as RFM, BRI, CUN-BAE and ABSI. At the same time, researchers point to the need for further verification of their usefulness in clinical practice and public health.
In-hospital rehabilitation in the treatment of multiple myeloma
Authors: Mińko Alicja , Szczypiór-Piasecka Karina , Kotrych Daniel
Published: September 2021

Wprowadzenie:  Szpiczak mnogi (MM) jest jednym z najczęstszych złośliwych nowotworów kości. Podstawową procedurą leczenia szpiczaka mnogiego jest chemioterapia połączona z autologicznym przeszczepem komórek macierzystych. Leczenie operacyjne, polegające na wycięciu guza, jest wskazane, gdy istnieje ryzyko patologicznego złamania kości lub ucisku guza na korzenie nerwowe. Konieczne jest stworzenie indywidualnego planu leczenia we współpracy interdyscyplinarnej. Ważnym elementem leczenia jest pomoc w zakresie rehabilitacji. Celem pracy było wskazanie procedur rehabilitacyjnych w leczeniu szpiczaka mnogiego po rekonstrukcji endoprotezy w okresie szpitalnym.Materials and methods: The work was written based on the medical history of a patient diagnosed with multiple myeloma in the proximal part of the right femur. The entire treatment procedure was carried out at the Department of Orthopedics, Traumatology and Oncology of the Musculoskeletal System, located at Unii Lubelskiej 1 in Szczecin.Results: Rehabilitation in the treatment process of patients after resection of the tumor in the proximal part of the femur and arthroplasty is implemented as early as 1 day after the surgery in order to activate the patient as soon as possible. The rehabilitation program was as individualized as possible to the patient and included modern techniques such as osteopathy and manulana therapy.Wniosek: Rehabilitacja jest nieodzownym elementem leczenia chorych na nowotwory. Wprowadzenie do rehabilitacji nowoczesnych technik wpływa pozytywnie na skuteczność terapii. Wczesne rozpoczęcie rehabilitacji przynosi wymierne korzyści w trakcie leczenia i powrót pacjenta do aktywnego udziału w życiu społecznym.
Sports injuries in indoor volleyball in people who play professionally and as a hobby
Authors: Mińko Alicja , Hilicka Zuzanna , Stępień Paulina , Bereda Zuzanna
Published: September 2021

Introduction: Volleyball is a sport that causes injuries very often. They often result from the lack of an appropriate warm-up, the intensity of exercises that do not match the body's capabilities, or the use of inadequate techniques and poorly selected sports equipment. The aim of the study was to compare the injuries of people who play volleyball professionally with people who play volleyball.Material and methods: The research was conducted among 144 volleyball players - 75 women (52.08%) and 69 men (47.92%). They were in three age groups: 18-20, 21-25 and over 25 years of age. The group was divided according to the type of game, i.e. whether it is a professional (49.31%) or a hobbyist (50.69%). Each of the volleyball players completed the questionnaire.Results: The group playing volleyball professionally comprised 71 people (49.31%), while the amateur group comprised 73 people (50.69%). Among people professionally training volleyball, injuries were observed in 64 (90.14%) people, while among people training amateur volleyball, injuries occurred more often in as many as 70 (95.89%) people. The most common trauma in the first and second groups was sprain, which occurred in the first group in 27 (38.03%) people, and in the second group - 26 (35.62%).Conclusions: Sprains are the most common injuries among people who play volleyball professionally and as a hobby. Most people who play volleyball professionally after an injury benefited from rehabilitation.
Anthropometric indicators associated with childhood obesity. Is it time for a BMI successor?
Authors: Walczyk Teresa
Published: September 2021

Childhood obesity and overweight have a wide impact on physical and mental health, and affect adulthood. In the last decade, scientists have been looking with concern at the increasingly frequent excess body weight in children and adolescents. Therefore, it is crucial to estimate the scale of the problem, and thus to correctly assess the level of adipose tissue. In assessing the nutritional status of the young, anthropometric measurements and indicators are used. Despite the widespread use of BMI (body mass index), this indicator is often criticized. BMI is frequently recognized as an imprecise tool and its use often results in misleading classification. Therefore, the aim of this study is to present selected, non-invasive anthropometric indicators related to overweight/obesity in children.Anthropometric indicators are relatively simple tools used in public health. However, the search for a simple and useful indicator is still ongoing, which will enable the assessment of the nutritional status both in clinical practice and in population studies. The paper presents the most frequently described anthropometric indicators in the literature: body mass index (BMI) and BMIz score, relative fat mass pediatric (RFMp), tri-ponderal mass index (TMI), pediatric body adiposity fat index (BAIp) and the mid-upper arm circumference (MUCA). The possibilities of application and their effectiveness for the estimation of adipose tissue content and the risk of coexisting diseases are presented.Although there is no consensus on the best tool, it is known that BMI will remain the main parameter in assessing nutritional status. Nevertheless, the authors suggest the usefulness of tools such as RFMp, TMI and MUAC as a good complement to the imperfections ascribed to BMI.
Comprehensive Rehabilitation After Reconstruction of the Anterior Cruciate Ligament
Authors: Besztak Dawid , Szczypiór-Piasecka Karina , Mińko Alicja , Antczak Krzysztof
Published: September 2021

Introduction: The knee joint is the second most frequently injured joint. Anterior cruciate ligament (ACL) injury is a relatively common injury to the inner part of the knee joint, mainly related to contact sports. Its rupture leads to instability of the entire joint. Two treatment options are possible: operative or conservative. Each of them is related to an appropriate rehabilitation process. The aim of this study was to define a comprehensive rehabilitation plan in patients after ACL rupture and meniscal suturing.Materials and methods: The work was written based on the medical history of the patient who was diagnosed with complete rupture of ACL, and then reconstruction was performed with the harvesting of a semitendinous and slender muscle graft.Results: The rehabilitation process can be divided into two stages: hospital and post-hospital. Rehabilitation in hospital conditions begins on the zero day after arthroscopy. The main goals of rehabilitation include: increasing the range of mobility, no myofascial dysfunctions, no thromboembolic complications, and the ability to self-service.Conclusion: Rehabilitation is an indispensable element of the treatment of patients after ACL reconstruction. Early initiation of rehabilitation brings tangible benefits during treatment and return to full physical fitness.
Physiotherapeutic proceedings with patient after petrochanteric fracture
Authors: Babkiewicz Damian , Szczypiór-Piasecka Karina , Mińko Alicja , Antczak Krzysztof
Published: September 2021

Introduction: The elderly are often affected by hip fractures. A trochanteric fracture is defined as when the fracture fissure is between the capsule and 3 cm below the lesser trochanter. The most common cause of these fractures is osteoporosis in the elderly. Treatment of a trochanteric fracture may be operative or conservative. The aim of this study was to define a plan of physiotherapeutic treatment in a patient after fixation of a trochanteric fracture with an intramedullary nail.Materials and methods: The work was written based on the medical history of a patient with a trochanteric fracture. The entire treatment procedure was carried out at the Department of Orthopedics, Traumatology and Oncology of the Musculoskeletal System, located at Unii Lubelskiej 1 in Szczecin.Results: Rehabilitation is an indispensable element in the treatment process of patients after a trochanteric fracture. It is implemented already from 1 day after the surgery in order to activate the patient as soon as possible. Such a procedure is to ensure faster activation of the patient and to avoid adverse changes resulting from too long immobilization.Conclusion: Rehabilitation is an indispensable element in the treatment of patients after a trochanteric fracture. Early patient activation reduces the risk of postoperative complications.
Neurosis in the eyes of society
Authors: Zimna Aleksandra Iwona , Wróblewski Hubert
Published: September 2021

Introduction: Neurosis is currently overused with words. Expressing itself as not infrequently, it does not initiate as a concept in the field of obsessive-compulsive disorders, i.e. obsessive-compulsive disorder, but misinterprets it as a state equated with nervousness.Aim of the study: The aim of the study is to analyze the knowledge and awareness of intrusion neurosis.Methods: The results were obtained on the basis of the conducted control of the questionnaire survey.Results: the results of the survey conducted were issued to 257 responses, 83.7% were obstacles, 16.3% were men. Ok. 9% of respondents say that obsessive compulsive disorder is transient. 21% of respondents believe that OCD is not a study of the health of adolescents (80.6%). the cause of this disorder. The intrusive uncertainty (80.5%) and the obsessive pursuit of order (77%) retained the characteristics of this disorder. Bear still 80% of enthusiastic nerves for leprosy, very common among people among people, who recognize people who have been selected among the crowd, passengers, passengers, and changed, are convinced that everyone is ill with everyone.Procedure: The conducted research shows that obsessive compulsive disorder is not fully educated in terms of the assessment of the procedure. Despite ignorance and ignorance of this end, it is often used in everyday speech and, despite being misidentified, as upset.
Neurological manifestations and complications of COVID-19. A literature review
Authors: Krasa Aleksandra Maria , Kozioł Magdalena , Piecewicz-Szczęsna Halina , Łopuszyńska Anna , Piekarska Ewa , Więsyk Piotr , Pawlicki Mateusz
Published: September 2021

Introduction. The first case of SARS-CoV-2 infection was identified in December 2019 in Wuhan, China. The disease spread rapidly worldwide and the WHO declared a pandemic on March 11, 2020. Although coronavirus disease 2019 (COVID-19) has been associated primarily with respiratory disorders, more and more research is focusing on neurological manifestations and complications.Objective. The aim of the review is to systematize and update the knowledge and available research on neurological complications among COVID-19 patients.Review methods. A systematic search of PubMed and Google Scholar databases was conducted for studies. The following keywords combinations were used: COVID-19, SARS-CoV-2 infection, neurological complications, neurological manifestations, neuroinvasion, neurovirulence.Results. The disease in most patients is characterized by mild to medium fever, fatigue, dry cough, dyspnea, muscle pain and headache. ACE2, which is the receptor for SARS-COV-2, is ubiquitously expressed in a variety of human organs, including the brain. Following previous reports, these receptors are expressed in both glial cells and neurons. Many studies have reported neurological symptoms and complications among  COVID-19 patients. The reported manifestations include: smell and taste disturbance, non-specific symptoms such as myalgia, headache and dizziness, acute cerebrovascular complications, encephalopathy, meningoencephalitis/encephalitis, seizure and complications of the peripheral nervous system.Conclusion. Healthcare professionals dealing with COVID-19, neuroscientists, and the general public should be aware of the neurological complications of COVID-19. Further studies are needed to assess the incidence of COVID-19 neurological complications in different populations and  more analyzes are also required to understand the detailed mechanism of how the virus affects the nervous system.
Relict root left in the mandible after extraction of the teeth 35 as a causative agent of the inflammation process in the region of mental foramen of the mandible
Authors: Zagacki Dawid , Pietryka Piotr , Ratajek-Gruda Monika , Janas-Naze Anna
Published: September 2021

We present a case of iatrogenic complication after extraction of the teeth 35 in 63-years old women. There was a root of the teeth left in the bone. It was a causative agent of pain sensations and inflammation of the surrounding tissues. Due to the close distance between the root, mandible canal and mental foramen of mandible the removal of relict root was burden with high risk of parasthesis.
Upper respiratory tract infection in children – immunostimulating treatment
Authors: Kaczmarczyk Dariusz , Zagacki Dawid , Morawiec-Sztandera Alina
Published: September 2021

This paper is a review of publications on viral infections of the upper aerotract in children. Recurring infections can be a consequence of the lack of treatment, inappropriate therapy or accompanying diseases. It is possible that an impaired condition of immunity leads to recurring infections. In this review a great deal of attention has been given to the mechanisms and the various stages of viral infection, and the onset of an organism’s defense mechanisms against viruses. The function of the immunomodulatory and immunostimulatory medical product, namely inosine pranobex has been evaluated in in vitro and in vivo studies. A review of the antiviral activity of inosine pranobex and the onset of cellular and humoral immunity has been presented.
Adverse reaction after transfusion of Red Blood Cells in a patient aged 97 years - case report
Authors: Kasperska-Dębowska Paulina Marta , Oleksy Eliza , Wojtczak Anna , Nowicka Małgorzata
Published: September 2021

During hospitalization 97 years old patient had blood transfusion. This procedure lead to overload of cardiovascular system. Pharmacotherapy gradually improved the general condition of the patient. The patient was discharged in a stable state. Doubts arise; when blood should be transfused, in which cases should a blood transfusion be discontinued, what should be the recommendation for a blood transfusion for older people over the age of 90. There is a need for further research in geriatrics regarding the transfusion of blood and its components.
Physical activity, lifestyle and nutrition as important indicators in the body mass index of children aged 3-6 years in the municipality of Mitrovica
Authors: Ramaj Lorik , Hasani Sadete
Published: September 2021

The purpose of this paper was to determine the level of physical activity and healthy nutrition in children aged 3-6 years from Mitrovica. The research was attended by 94 children aged 3 - 6 years from two kindergartens in Mitrovica. As a parameter that measured the weight and height of the children,  it was calculated with the standardized procedure of Body Mass Index (BMI)  then was calculated according to the standard formula used by (Betterhealth, 2016). Also, after extracting other information through the questionnaire, a quantitative research was conducted through the parents of 94 children who were part of the measurements. A questionnaire was used to collect the data, which was previously translated and adapted into Albanian with permission to use it. The questionnaire was combined by three different questionnaires such as: the lifestyle questionnaire (Wilson et al., 2008), the physical activity questionnaire Pre-PAQ test (Dwyer et al., 2011) and the nutrition questionnaire (Rysha et al., 2017). The data collected during the research were placed in the statistical program SPSS version 21.0, and the presentation of this data was done through a descriptive analysis. The results that came from  this research showed that the effect of physical activity, lifestyle and nutrition have quite a high impact on body mass index in children. From the results we saw that the children of the two kindergartens from the municipality of Mitrovica did quite well in terms of physical activity, where in the questionnaires that were answered 89.4% of children were active more than an hour a day by walking and doing other activities. Also, the results regarding the questions in which they were asked about the time that children use the phone were at a satisfactory level, where a large percentage of parents, 77.7%, declared that their children did not use the phone  more than an hour a day. While in terms of nutrition, there have been many results which need more detailed analysis and to take preventive measures such as consumption of energy drinks, carbonated beverages, fast food, etc. From the measurement of children aged 3-4 years only one child turned out to be overweight with BMI = 18.7, while the rest came out with BMI with normal limits. As for children aged 4-5 years, one child turned out to be underweight with BMI = 12.4 and one obese with BMI = 21.9 and the others with BMI with normal limits. And out of children aged 5-6 years one child came out overweight with BMI = 17.7 and two others obese, one with BMI = 19.7 and the other BMI = 19.8 and the other children had normal weight (Betterhealth, 2016).
Acne vulgaris and mental health
Authors: Pawlicki Mateusz , Łopuszyńska Anna , Kozioł Magdalena , Krasa Aleksandra , Piekarska Ewa , Piecewicz-Szczęsna Halina
Published: September 2021

Introduction: Acne vulgaris is one of the most common diseases in the world, which affects millions of people. Despite its objectively mild clinical severity, it is able to markedly change one’s appearance. Moreover it is said to be one of many factors that are responsible for mental health impairments.Results: Studies showed significant relation between acne and psychological disorders. Both depression and anxiety scores were higher in individuals with acne compared to healthy ones. Some studies reported an increased risk of suicide in this group as well. Research which included quality of life evaluation showed its impairment in larger part of respondents.Conclusions: Acne vulgaris is linked with an increased risk of serious psychiatric disorders. Therefore it is important to think about them when this condition is diagnosed.