bluuebunny/crossref_metadata_2025 huggingface dataset:
SCIENCE ANXIETY AS A PREDICTOR OF STUDENTS PREFERRED SUBJECT IN THE POST JUNIOR SECONDARY CLASSROOM
Authors:   Department of Integrated Science Kogi State College of Education, Ankpa., Rukijat Suleiman , Karimat Ahmed ,   Department of Integrated Science Kogi State College of Education, Ankpa.
Published: November 2021

The world, including Nigeria, is increasingly seeking to improve its educational system to attain the desired scientific-driven society. Thus, education is geared towards science, technology, engineering, and mathematics (STEM). To this effect, Nigeria is investing in science-based education, and the students are encouraged to embrace science in their educational pursuits. Based on this, the present study examined students subject preference in the post junior secondary classroom based on science anxiety. One hundred and sixty-six students drawn from public and private secondary schools in the Kogi State participated in the study. Their level of science anxiety was assessed with the Science Anxiety Scale (Oludipe & Oludipe, 2019). The simple regression analysis performed on the data revealed that science anxiety statistically significantly predicted the respondents subject preference. Thus, the study concludes that science anxiety is a positive determinant of students choice of subject in the secondary school classroom.
THE ROLE OF COOPERATIVE INSTRUCTIONAL STRATEGIES ON STUDENTS COMMITMENT TO PHYSICS IN RURAL COMMUNITIES OF KOGI STATE
Authors:   Department of Physics Kogi State College of Education, Ankpa., A. Abraham Nwaba , Sunday Musa ,   Department of Physics Kogi State College of Education, Ankpa.
Published: November 2021

Physics has continued to generate favorable commendation in the educational landscape of every society in the modern-day world. However, the concern about the increasing decline in students performance and the growing purported difficulties associated with the subject has continued to attract research attention. There are intimations that secondary school students in rural communities are more likely to commit less effort to science subjects. Thus, the primary purpose of this study was to investigate cooperative instructional strategy as a well-researched teaching method that could also improve students commitment to physics. Two hundred and nineteen secondary school students in the rural communities in Kogi State, Nigeria, enrolled in the science classes participated in the study. A quasi-experimental pre-test, post-test research design was employed for the study. The participants were grouped into two different groups for the pre-test and post-test analyses. The experimental group was exposed to the cooperative instructional teaching method, while the control group was taught conventionally. An independent-samples t-test was performed to determine differences between the observed and the control groups on a commitment to physics in the post-test study with a statistically significant MD= 10.85, t (117) = 20.026, p = .001. It was concluded that cooperative instructional strategy enhances students commitment to physics. The study recommends robust training of teachers on the use of collaborative instructional strategies.
WATER SOURCES AND WATER-BORNE DISEASES: A STUDY OF SEASONAL DISPARITIES IN BACTERIOLOGICAL COMPOSITIONS OF WATER SOURCES IN KOGI STATE, NIGERIA
Authors:   Department of Biology Kogi State College of Education, Ankpa., Salifu Melinga
Published: November 2021

Water is an essential component of human living and crucial in metabolism, substrate transport across membranes, cellular homeostasis, temperature regulation, and circulatory function. Access to quality water is a critical concern of any society. However, water shortage remains the central problem of many households across the universe, prompting people to depend on water sources that are considered unhealthy for human consumption. The primary purpose of this study was to examine the bacteriological compositions of water sources in Kogi State based on seasonal disparities. Water samples were obtained from streams and hand-dug wells within the Ankpa and Obajana areas during the rainy and dry seasons. The analysis conducted on the samples revealed that the water sources were heavily contaminated with bacteria at both seasons.
A REVIEW ON ANALYTICAL STUDIES AND PHARMACOLOGICAL EVALUATION OF POLYHERBAL FORMULATIONS
Authors:   Department of Pharmacognosy and Phytochemistry, Jamia Salafiya Pharmacy College, P.O Pulikkal, Malappuram, Kerala, India 673637., P. Nafha , P.S Shijikumar ,   Department of Pharmaceutical Chemistry & Analysis, Jamia Salafiya Pharmacy College, P.O Pulikkal, Malappuram, Kerala, India 673637., Baboo R.V Celestin ,   Head of the Department, Department of Pharmacognosy and Phytochemistry, Jamia Salafiya Pharmacy College, P.O Pulikkal, Malappuram, Kerala, India 673637.
Published: November 2021

In standardization process, quality and purity of crude drugs are evaluated by various parameters. For herbal formulations, along with the chemical, physical, phytochemical, in- vivo and in- vitro parameters, it is significant to determine its quality standards. In traditional system of medicine, the developments of analytical parameters are an important step in establishing quality of products, presence of phytoconstituents and its therapeutic efficacy. In this review, Avipathy and Avipattikar churna, both are polyherbal formulations having nine similar herbal ingredients (Sunthi, Marica, Pippali, Amlaki, Musta, Vidanga, Elaichi, Patra, Trivit) but they are different in terms of indication and method of administration. Avipathy churna is targeted mainly to achieve pitta balance whereas Avipattikar churna for all the three dosha specified in Ayurvedic system of medicine. This review provides data on quality control and analytical studies such as Gas Chromatography coupled with Mass Spectrometry (GC-MS), High Performance Thin Layer Chromatography (HPTLC), Atomic Absorption Spectroscopy (AAS), Ultraviolet spectroscopy (UV) and pharmacological evaluation of Avipathy and Avipattikar churna. The analytical study shows the presence of various marker compounds. This helps to draw new conclusions from existing data to identify research areas. They assure the quality, purity and safety of herbal formulations.
Design and Development of Transdermal Patches
of Antipsychotic Drug: In vitro and Ex vivo
Characterization
Authors: Peddapalli Himabindu , Rajagoni Anjaneyulu , Pagilla Preethi , Perumala Jerusha , Puppala Shilpa , Sunand Katta , Bakshi Vasudha
Published: November 2021

The purpose of the present research work was to design, assess, and estimate the developed transdermal matrix-type
formulation comprising levosulpiride hydrochloride with the objective of enhancing the bioavailability and compliance of
the patient. Transdermal films of levosulpiride were developed using a solvent casting method by hydroxypropyl methylcellulose
(HPMC) E 15, Eudragit RL 100, and Eudragit RS100. In current research work, propylene glycol and oleic acid
was used as plasticizer and permeation enhancers in different fractions. Among the batches, drug content uniformity with
all formulations was perceived between 91.6 to 98%. Folding endurance of patches was good and indicates satisfactory
flexibility. Developed transdermal films had the necessary physicochemical properties, for example, uniformity of drug
content, weight, thickness, folding endurance, and dampness content. Franz diffusion cell was used for in vitro diffusion
studies utilizing dialysis membrane as a pervasion boundary. Formulation F5 (Eudragit RL 100-1%, HPMC E15-9%) was
found to be best among all batches of its consistent release rate for 12 hours and the extent of drug release 97.76%. F5
was the most palatable formulation as it firmly meets the standards and continuously permeated drugs for 12 hours that
can keep up desired therapeutic concentration in plasma. The patches were exposed to transient stability studies and were
observed to be constant and stable.
International economic and social determinants of the state economic security: A causal analysis
Authors: Orlov Volodymyr , Bukhtiarova Alina , Marczuk Marcin , Heyenko Mykhaylo
Published: November 2021

The priority task for ensuring the economic security of a country, which is especially noticeable in the rapidly changing conditions of the contemporary global world, is to forecast challenges and threats. Economic security is one of the necessary conditions for state development, which provides guidelines for making major social and economic decisions. There are a few studies on the determinants of the economic security and no data about security determinants that are required to monitor it. The study aims to identify possible links between leading determinants of the economic security. For this purpose, on the example of Ukraine, causal links between the formation of real GDP (as the leading determinant that characterizes the economic security of the state), 11 determinants that indicate the level of international economic development, and 6 determinants of social development for the period 2014–2020 were determined. With a 5% level significance, the impact on the volume of real GDP of 14 determinants of state economic security was noted and specific time lags were defined. Besides, the bilateral causal effect and lack of causal connection between individual determinants were mentioned. Findings are helpful for effective public administration. In addition, active measures are needed to combat corruption, shadow and criminal economy, and state protection of domestic producers operating in the military, food, information, and energy security sectors. AcknowledgmentAlina Bukhtiarova gratefully acknowledges financial support from the Ministry of Education and Science of Ukraine (0120U100473).
Efecto en la composición nutricional de huevos azules de gallinas criollas Huilliches mediante la inclusión de compuestos naturales del sur de Chile ricos en antioxidantes y omega 3
Authors: Seperiza Astrid , Flores Corina , Flórez-Méndez Jennyfer
Published: November 2021

El huevo es un alimento que presenta alto valor nutritivo, aporta elevada proporción de proteínas, vitaminas y minerales, relativamente bajo de energía, lo que lo convierte en un alimento con alta densidad de nutrientes. El objetivo de este estudio fue determinar el efecto de la inclusión de materias primas autóctonas del sur de Chile que contienen compuestos bioactivos en la alimentación de las gallinas criollas sobre la composición en ácidos grasos y capacidad antioxidante de sus huevos. Para esto, se elaboraron 8 dietas experimentales y una dieta de grano comercial y una dieta control, las dietas experimentales fueron formuladas en base a tres niveles de inclusión de fuentes de omega 3 (harina de salmón, chorito y microlaga) y tres niveles de fuentes de antioxidantes (harina de mora, frutilla y pepa de uva). El ensayo experimental tuvo duración de ocho semanas, donde se alimentaron 360 gallinas, distribuidas en 9 explotaciones avícolas. Al final de este período, los huevos de los tratamientos fueron liofilizados y se determinaron los ácidos grasos por cromatografía de gases y capacidad antioxidante por el método ABTS y DPPH. Los huevos, donde las gallinas fueron alimentadas con las dietas 7 y 8, compuestas por harina de alga y de pepa de uva, fueron aquellas que presentaron un mayor contenido del Ácido docosahexaenoico (DHA), 3,43 y 3,46 / 100 g respectivamente. Por otro lado, los huevos puestos por gallinas que se alimentaron de la dieta 5, compuestas por harina de salmón, chorito, mora y frutilla, fueron los que presentaron una mayor capacidad antioxidante.
AS POLÍTICAS PÚBLICAS NO ATUAL CONTEXTO BRASILEIRO
Authors: Siqueira Santos Cleidijane , Melo de Morais Erivania
Published: November 2021

Esta entrevista com a docente e pesquisadora do Departamento de Ciências Políticas da Universidade de São Paulo-USP e Diretora do Centro de Estudos da Metrópole, um dos Centros de Pesquisa, Inovação e Difusão-CEPIDs da Fundação de Amparo à Pesquisa do Estado de São Paulo- FAPESP foi realizada no dia 16 de Julho de 2021 das 14h às 15h via Google meet, sendo parte integrante do Dossiê “Interdisciplinaridade e Políticas Públicas”. Para o desenvolvimento desta entrevista, buscou-se sistematizar reflexões que estivessem interligadas com os debates suscitados no referido Dossiê, assim, elaboramos quatro eixos que permitissem que a docente/pesquisadora entrevistada, ficasse livre para responder, dialogar e refletir de forma ampla e complexa, desse modo, no decorrer da entrevista, suscitaram-se outras inquietações a partir dos eixos propostos, enriquecendo o debate e as reflexões, promovendo um momento de muitas aprendizagens acerca do campo das políticas públicas no Brasil. Dos eixos debatidos, abordamos: a noção de política pública pensada pela entrevistada; a análise dos impactos da emenda constitucional 95/2016; o papel da universidade no campo de tensionamentos educacionais; e por fim, uma análise da relevância interdisciplinar, para o campo das políticas públicas.
INTERDISCIPLINARIDADE E POLÍTICAS PÚBLICAS
Authors: Siqueira Santos Cleidijane , Melo de Morais Erivania , Alves de Paiva Irene , Araújo da Costa João Bosco
Published: November 2021

Enquanto campo de estudo das ciências sociais e objeto de planejamento da ação pública e governamental, as políticas públicas têm uma relevância crucial no contexto brasileiro no que se refere ao atendimento das demandas sociais, bem como, na busca de reduzir as desigualdades sociais seculares e persistentes no país através da criação de programas de desenvolvimento. Assim, em um contexto em que as diversas expressões da questão social são agudizadas e provocam um cenário de desigualdade e palperismo atravessados pela crise social, política, econômica, educacional, na saúde, e em outras áreas, este dossiê se propôs a pensar e discutir as políticas públicas em uma perspectiva interdisciplinar, a fim de colocar para o debate reflexões que pudessem permitir uma análise teórica-metodológica e da realidade social brasileira para pensar em alternativas contra hegemônicas de resistência e de busca para uma futura transformação societária.
METODOLOGIAS DE CUSTEIO E PREÇO DE VENDA: UM ESTUDO SOBRE AS PRÁTICAS DOS EMPREENDIMENTOS ECONÔMICOS SOLIDÁRIOS
Authors: Nascimento Rayanna Nayhara Oliveira , Rêgo Thaiseany de Freitas , Dias Thiago Ferreira
Published: November 2021

O estudo objetivou identificar quais são as metodologias de custeio e preço de venda adotadas pelos Empreendimentos Econômicos Solidários (EES) de Mossoró/RN, para a formação do preço justo de seus produtos e serviços. Para tanto, utilizou-se de um estudo do tipo multicaso que se pauta na realização de entrevistas semiestruturadas e na análise de conteúdo. As entrevistas foram realizadas junto aos indivíduos que atuam no controle e na marcação do preço de venda dos artigos produzidos pelos EES. A apreciação das entrevistas foi pautada na análise de conteúdo, com o auxílio do software Atlas.ti (versão 5.0), o que permitiu a codificação e categorização dos diálogos. Considerando os mais conhecidos métodos de custeio (absorção, variável e por atividades) e formação do preço de venda, destaca-se que as práticas adotadas pela Acrevi são insuficientes para a determinação do preço justo de venda. Já no que concerne a Coopermups e o GMUPA, observa-se que se utilizam da gestão de mão de obra direta e indireta, da matéria-prima e materiais indiretos como medidas essenciais para a determinação do preço justo.Palavras-chave: Gestão de custos. Formação do preço. Economia solidária. Preço justo.
PRÁTICAS GERENCIAIS DE MICRO E PEQUENAS EMPRESAS
Authors: Santos Vanderlei dos , Dorow Diego Roberto , Beuren Ilse Maria
Published: November 2021

O estudo investiga quais são os instrumentos e procedimentos gerenciais utilizados em micro e pequenas empresas na tomada de decisão. Pesquisa descritiva com abordagem quantitativa foi realizada por meio de levantamento, tendo como amostra as 41 empresas respondentes do questionário. A análise dos dados foi realizada com aplicação de estatística descritiva, entropia informacional e o teste Mann-Whitney U. Os resultados mostram que nas empresas pesquisadas a tomada de decisão é baseada na experiência do proprietário. As empresas têm conhecimento do resultado mensal, mas não o discutem com o seu contador. A maioria das empresas não utiliza a contabilidade na tomada de decisão, seja pelo fato da informação contábil não refletir a real situação da empresa e/ou o gestor desconhecer sua utilidade. Os instrumentos gerenciais mais utilizados na tomada de decisão são controles operacionais e planejamento tributário, e os menos utilizados são demonstrações contábeis, métodos de custeio e outros instrumentos gerenciais. A maioria destas empresas não conhece ou não faz uso de instrumentos que orientam as estratégias e ações organizacionais, como o planejamento estratégico e o orçamento.Palavras-chave: Instrumentos gerenciais. Procedimentos gerenciais. Tomada de decisão. Micro e pequenas empresas.
CONTABILIDADE AMBIENTAL – UMA ANÁLISE DA APLICAÇÃO PRÁTICA COMO POTENCIALIZADORA DE INFORMAÇÕES SOCIOAMBIENTAIS NAS DEMONSTRAÇÕES CONTÁBEIS
Authors: Oleiro Walter Nunes , Schmidt Elisabeth Brandão
Published: November 2021

A contabilidade ambiental, como uma ramificação da contabilidade tradicional, tem como objetivos: identificar, mensurar e esclarecer os eventos e transações econômico-financeiros que estejam relacionados com a proteção, preservação e recuperação ambiental, ocorridos em um determinado período, visando à evidenciação da situação patrimonial de uma entidade. Diante disto, o presente estudo visa investigar e analisar que contribuições a contabilidade ambiental proporciona na evidenciação de informações ambientais através das Demonstrações Contábeis. Para isto, buscou-se publicações sobre o tema nos periódicos da área de Ciências Contábeis, com conceito qualis B1 e B2, no período de 2011 a 2014. Foram analisados 16 artigos de um total de 640, utilizando-se o método da análise de conteúdo. A pesquisa caracteriza-se quanto aos objetivos como descritiva, com abordagem qualitativa e documental quanto aos procedimentos. Como resultado da análise, conclui-se que a contabilidade ambiental não é utilizada para evidenciar as informações de natureza ambiental.Palavras-chave: Evidenciação, Contabilidade Ambiental, Educação Ambiental.
Determinação da espessura da interface sedimento-embasamento da Bacia Sergipe-Alagoas a partir da assinatura gravimétrica.
Authors: Dutra Alanna Costa
Published: November 2021

Este trabalho  utilizou dados gravimétricos para pesquisar o arcabouço da bacia sedimentar Sergipe-Alagoas e parte do embasamento. Os principais objetivos são estimar parâmetros como espessura do embasamento e variação lateral do contraste de densidade nos domínios Estância, Canudos-Vaza-Barris, Macururé e Terreno Pernambuco-Alagoas no trecho adjacente à Bacia Sergipe-Alagoas, utilizando medidas geológicas e geofísicas em rochas coletadas na superfície. A partir da  dos dados adquiridos realizamos o processamento e interpretação de dados gravimétricos ao longo da região do embasamento adjacente e sua extensão para a Bacia Sergipe-Alagoas, para que fosse feita uma modelagem gravimétrica dos domínios crustais e suas relações tectônicas. Para delinear o relevo do embasamento da Bacia Sergipe-Alagoas foi necessário conhecer as anomalias gravimétricas e o contraste de densidade na superfície da bacia. Com estas informações foi possível estimar, além do relevo, o valor do contraste de densidade na superfície desta bacia sedimentar, sendo fornecida a anomalia gravimétrica e a profundidade do embasamento em alguns pontos da bacia. A grande vantagem dos métodos gravimétrico é a boa capacidade de recobrimento espacial com custos razoáveis, e são bastante utilizados para a detecção, localização e delineação de feições estruturais.
Distribuição espaço-temporal dos desastres climáticos de estiagem e de seca na região do Curimataú paraibano
Authors: Araújo Maressa Oliveira Lopes , Silva Natieli Tenório da , Sérgio Matheus Alexandre de Souza , Moura Marcelo de Oliveira
Published: November 2021

O presente trabalho tem por objetivo analisar a distribuição espaço-temporal dos reconhecimentos de Situação de Emergência associados à dinâmica climática na região pluviometricamente homogênea do Curimataú Paraibano, durante o período de 2003 a 2016, com enfoque aos decretos de estiagem e seca. Para isso, os dados utilizados foram adquiridos no site do Ministério da Integração Nacional, na página da Secretaria Nacional de Proteção e Defesa Civil, conforme disponibilizados pelas portarias reconhecidas de Situação de Emergência – SE. Como resultado principal, constatou-se um total de 287 reconhecimentos na área de estudo. Destes, 258 correspondem aos desastres de tipo estiagem e 29 do tipo seca. Entende-se que os resultados tiveram um cunho mais descritivo, sendo necessários estudos mais aprofundados sobre o tema.
Ocupação urbana em área de dunas no loteamento água das fontes no Município de São Gonçalo do Amarante/RN.
Authors: Medeiros Galvão Sílvio Petronilo de , Lima de Carvalho Segundo Espedito , Godeiro de Lima Pedro Henrique , Dantas Borges Filho Ridon
Published: November 2021

Os Ecossistemas Dunares tem grande importância pela sua ampla diversidade. No município de São Gonçalo do Amarante/RN existe apenas uma pequena área de dunas, à nordeste, o qual a anos vem sofrendo intervenção antrópica. O presente trabalho busca analisar a ocupação urbana em área de dunas no município, no que diz respeito a abertura de uma rua no Loteamento Água das Fontes. Para tal, foram utilizados software SIG - Sistema de Informação Geográfica e visita In loco. A partir desta análise de viabilidade ambiental, foi possível identificar passíveis a vulnerabilidade ambiental para tal intervenção, em áreas de dunas e lagoas interdunares.
Identificação de serviços ecossistêmicos na praia de Ponta Negra, Natal - RN.
Authors: Silva de Araújo Isailma , Câmara Maciel Ana Beatriz , Vieira Ferreira Joyce Clara , Carvalho Lima Zuleide Maria
Published: November 2021

O município de Natal - RN apresenta uma forte ocupação de sua zona costeira, sendo um local de constante especulação imobiliária que tem acarretado diversos problemas de ordem ambiental. O objetivo dessa pesquisa é identificar os serviços ecossistêmicos prestados pela praia de Ponta Negra, serviços esses agrupados nas classes de Regulação e Manutenção, Provisão e Culturais. A escolha dessa praia deve-se ao fato de ser uma das mais famosas do estado e, consequentemente, uma das mais frequentadas por turistas e também pela população local. A praia de Ponta Negra apresenta um nível de uso extremamente elevado e sua ocupação vem causando sérios prejuízos ambientais e também financeiros à toda a população de Natal.
Precipitação Geoquímica em Ambientes Evaporíticos/Hipersalinos – o caso das Salinas Solares do Brasil
Authors: Costa Diógenes Félix da Silva , Da Silva Diego Emanoel Moreira , Souza Ana Caroline Damasceno , Saldanha Denise Santos , Lillebø Ana Isabel
Published: November 2021

As salinas têm sido utilizadas pelo homem há milênios, sendo compostas por uma série de tanques rasos e interconectados, nos quais a água do mar/estuário é captada e transferida de um tanque para outro por gravidade ou por bombeamento, onde a produção do sal se dá a partir da saturação e precipitação dos sais por evaporação solar. Objetivou-se identificar e descrever o processo de deposição e formação de sais em ambientes evaporíticos artificiais (salinas solares) do Brasil. Verificou-se que a precipitação de sais nas salinas incluiu os compostos menos solúveis na base para o mais solúvel na parte superior da sequência, na seguinte ordem: carbonatos (CaCO3), gipsita (CaSO42H2O), halita (NaCl), sais de potássio - silvinita (sistema NaCl-KCl), e magnésio - biscofita (MgCl2.6H2O). Os carbonatos precipitam-se em salinidades em torno de 50 a 80gL-1, seguidos dos sulfatos, que precipitam-se gradativamente ao longo dos evaporadores da salina, até atingir seu máximo de precipitação entre 150 e 160gL-1. As maiores quantidades de cristais de halita são formadas quando a concentração total da salinidade atingiu um valor acima de 240gL-1. A variação e sequência de deposição evaporítica nas salinas apresentam limites diferentes de dissolução no ambiente, vindo a precipitar-se quando atingem saturações máximas.
Georges Bertrand e a Análise Integrada da Paisagem em Geografia
Authors: Bernardino Santos de Medeiros Diogo , Oliveira Alisson Medeiros de , Diniz Marco Túlio Mendonça
Published: November 2021

No sentido de colaborar com o conhecimento sobre a análise da paisagem em Geografia, propõe-se, aqui, um artigo de revisão bibliográfica que trate, de maneira crítica e analítica, das contribuições teórico-metodológicas de Georges Bertrand para essa temática. Esse autor, em 1968, no contexto de renovação da Geografia e de desenvolvimento progressivo de sínteses naturalistas mais rebuscadas, concebeu a Análise Integrada da Paisagem (Paisagem e Geografia Física Global; Teoria Geossistêmica Bertrandiana) – amplamente difundida na Geografia brasileira. No presente trabalho, busca-se abordar o contexto histórico-científico dessa teoria, os seus conceitos-chave, sua singularidade perante sínteses naturalistas similares, a metodologia proposta e as principais críticas e proposições a ela direcionadas. Expecta-se que o referido trabalho – de cunho panorâmico – favoreça a inserção dessas concepções nas novas gerações acadêmicas de Geografia.
FLIGHT SAFETY – NEW CONCEPTUAL AEROMEDICAL ASPECTS
Authors:   Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Praskurnichiy E.A. , Kulichenko V.P. ,   Central Hospital for Flight Test Crew Expertise, Zhukovsky, Moscow Region, Polubentseva E.I. ,   Central Hospital for Flight Test Crew Expertise, Zhukovsky, Moscow Region, Ivanov I.V. ,   Sechenov First Moscow State Medical University (Sechenov University)
Published: November 2021

The authors examined the current conception of flight safety, medical risks management, prevention of accidents due to the human factor, and updated flight safety definition. Health and physiological examinations within the pilot medical certification procedure are, unconditionally, important determinants of flight safety. However, maintenance and realization of key professional qualities confront a number of extra- and intersystem factors that can create some level of risk. Mitigation of these risks and medical risks management should be taken as the basis for preventing aviation accidents caused by the human factor.
Amlodipine Induced Gum Hypertrophy: A Rare Case Report
Authors: Midha Naresh , Reddy Suryanarayana Challa , Chhabra Vivek , Kumar Deepak , Bohra Gopal Krishna
Published: November 2021

Background:

DIGO or drug-induced gingival overgrowth occurs as a side effect of certain drugs. Until now, the etiology of drug-induced gingival overgrowth is not clearly understood. Among the calcium channel blockers, nifedipine has been shown to be most frequently associated with drug-induced gingival hyperplasia. Amlodipine is a comparatively newer calcium channel blocker that with a longer duration of action and lesser side effects as compared to nifedipine. There are only certain case reports of amlodipine-induced gum hyperplasia.

Case presentation:

We report a case of amlodipine-induced gum hyperplasia in a 66-year-old hypertensive patient taking amlodipine at a dose of 5 mg once a day. There was significant regression of gum hypertrophy after substitution of amlodipine by Losartan.

Conclusion:

Amlodipine is one of the commonly prescribed antihypertensive drugs, and gingival hyperplasia is one overlooked side effect in patients taking amlodipine. Awareness of this potential side effect of amlodipine may be helpful to reduce the anxiety of patients and the cost of diagnostic procedures.
Preclinical Assessment of [68Ga]Ga-Cell Death Indicator (CDI): A Novel
hsp90 Ligand for Positron Emission Tomography of Cell Death
Authors: Shon Ivan Ho , Kumar Divesh , Schreuder Mark , Guille Jennifer , Doan John , Sathikumar Chithra , Van Khang , Chicco Andrew , Hogg Philip J.
Published: November 2021

Background:

4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when
conjugated with a bifunctional chelator 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-
oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid (NODAGA) (hereafter referred to as Cell Death
Indicator [CDI]), enters dead and dying cells and binds to 90kDa heat shock proteins (hsp90).

Objective:

This study assesses stability, biodistribution, imaging, and radiation dosimetry of [68Ga]-
Ga-CDI for positron emission tomography (PET).

Methods:

Preparation of [68Ga]Ga-CDI was performed as previously described. Product stability
and stability in plasma were assessed using high-performance liquid chromatography. Biodistribution
and imaging were conducted in ten healthy male Lewis rats at 1 and 2 h following intravenous
[68Ga]Ga-CDI injection. Human radiation dosimetry was estimated by extrapolation for a standard
reference man and calculated with OLINDA/EXM 1.1.

Results:

Radiochemical purity of [68Ga]Ga-CDI averaged 93.8% in the product and 86.7% in plasma
at 4 h post-synthesis. The highest concentration of [68Ga]Ga-CDI is observed in the kidneys;
[68Ga]Ga-CDI is excreted in the urine, and mean retained activity was 32.4% and 21.4% at 1 and 2
h post-injection. Lower concentrations of [68Ga]Ga-CDI were present in the small bowel and liver.
PET CT was concordant and additionally demonstrated focal growth plate uptake. The effective
dose for [68Ga]Ga-CDI is 2.16E-02 mSv/MBq, and the urinary bladder wall received the highest
dose (1.65E-02 mSv/Mbq).

Conclusions:

[68Ga] Ga-CDI is stable and has favourable biodistribution, imaging, and radiation
dosimetry for imaging of dead and dying cells. Human studies are underway.
The Spectrum of Biochemical Alterations with Molecular and Serological Biomarkers in the Diagnosis of COVID-19: Searching
for Novel One to Identify Disease Earlier with Better Prognosis and Drug Discovery
Authors: Ray Suman Kumar , Mukherjee Sukhes
Published: November 2021

:

Clinical and laboratory predictors of progression to serious and deadly
forms are crucial in the fight against COVID-19, which has now become a worldwide
pandemic. The clinical laboratory's vital role in today's crises has never
been more obvious. These subjective clinical signals can be perceived more confidently
during an examination with the help of biomarkers. To best combat present
and future pandemics, global unity on test access is required, as well as infection
prevention and diagnostic measures that are tightly linked.
COMPARISON OF HYDRODISECTION INJECTION BETWEEN TRIAMCINOLONE ACETONIDE VERSUS DEXAMETHASONE IN CARPAL TUNNEL SYNDROME
Authors: Mardi Santoso Widodo , Munir Badrul , Ari Setianto Catur , Damayanti Ria , Agma Sheny
Published: November 2021

Background: Carpal tunnel syndrome (CTS) is the most common nontraumatic peripheral neuropathy, which is caused by suppression of the median nerve below the transverse carpi ligament. Local corticosteroid injection is considered the fastest and most effective method for improving symptoms that occur in CTS. There are several corticosteroid agents that can be used, but there are no objective standards that can explain the most ideal drugs. Objective: To compare the effectiveness of hydrodisection injection therapy of triamcinolone acetonide versus dexamethasone on carpal tunnel syndrome. Methods: This study involved 30 participants who were diagnosed with CTS and fulfilled the inclusion criteria and no exclusion criteria were obtained. Participants were divided into two treatment groups; the first group (n = 15) injected with Triamcinolone Acetonide (TCA) 10mg / 1ml and lidocaine 1% 1 ml and the second group (n = 15) injected with Dexamethasone 4mg / 0.8ml and lidocaine 1% 1 ml. The NRS, FSS, and SSS parameters were assessed before injection and 4 weeks after injection in each agent. Then compared these parameters at 4 weeks after injection compared to the TCA group with the dexamethasone group. Results: NRS score before and 4 weeks after TCA injection (sig 0.000; p <0.05), SSS (sig 0.001; p <0.05) and FSS (sig 0.020; p <0.05), and NRS score before and 4 weeks after dexamethasone injection (sig 0.001; p <0.05), SSS (sig 0,000; p <0.05) and FSS (sig 0,000; p <0.05). At 4 weeks after injection of TCA compared to dexamethasone there were no significant results on NRS (sig 0.237; p> 0.05) and FSS (sig 0.119; p> 0.05), while SSS values were significantly different (sig 0.027; p <0.05). Conclusion: Significant improvement in NRS, FSS and SSS score was obtained at 4 weeks after hydrodisection injection, both with TCA and dexamethasone. At 4 weeks after TCA injection compared to dexamethasone, there were no significant differences in NRS and FSS scores, whereas SSS score differed significantly. Both injection agents are equally effective in treating CTS, but dexamethasone produces a better improvement in SSS score.
Teaching factory management during the Covid-19 pandemic
Authors: Vidiastuti Yozi , Purwanto Nurtanio Agus
Published: November 2021

This research aims to determine how the teaching factory at SMK SMTI Yogyakarta handled during Covid-19 pandemic. A descriptive qualitative case study approach was used as the method. Semi-structured interview techniques, observation, and documentation were used to collect data. The interviewed data was collected from 3 informants. This study used triangulation techniques to check the validity of the data. The triangulation technique in this study used source triangulation, which compares the interview results of 3 informants to check the compatibility of the information obtained, then analyzed using an interactive model from Milles and Huberman. The implementation of the teaching factory at SMK SMTI Yogyakarta aims to improve student competence so that students can adapt and become accustomed to conditions in the real industrial world under the teaching factory’s objectives. Schools continue to work with the industry on the implementation of the teaching factory in order to achieve the teaching factory’s goals, and SOP (Standard Operational Procedures) are tailored to SOP from industries related to established health protocols. The implementation of the teaching factory can be done by forming a BLUD at the school level, which will form a learning process that is centered on entrepreneurship, with the income generated from the production used as capital, especially for SMK SMTI Yogyakarta.
Effects of Urban Green Space on Cardiovascular and Respiratory Biomarkers in Chinese Adults: Panel Study Using Digital Tracking Devices (Preprint)
Authors: Yang Lin , Chan Ka Long , Yuen John W M , Wong Frances K Y , Han Lefei , Ho Hung Chak , Chang Katherine K P , Ho Yuen Shan , Siu Judy Yuen-Man , Tian Linwei , Wong Man Sing
Published: November 2021

BACKGROUND

The health benefits of urban green space have been widely reported in the literature; however, the biological mechanisms remain unexplored, and a causal relationship cannot be established between green space exposure and cardiorespiratory health.

OBJECTIVE

Our aim was to conduct a panel study using personal tracking devices to continuously collect individual exposure data from healthy Chinese adults aged 50 to 64 years living in Hong Kong.

METHODS

A panel of cardiorespiratory biomarkers was tested each week for a period of 5 consecutive weeks. Data on weekly exposure to green space, air pollution, and the physical activities of individual participants were collected by personal tracking devices. The effects of green space exposure measured by the normalized difference vegetation index (NDVI) at buffer zones of 100, 250, and 500 meters on a panel of cardiorespiratory biomarkers were estimated by a generalized linear mixed-effects model, with adjustment for confounding variables of sociodemographic characteristics, exposure to air pollutants and noise, exercise, and nutrient intake.

RESULTS

A total of 39 participants (mean age 56.4 years, range 50-63 years) were recruited and followed up for 5 consecutive weeks. After adjustment for sex, income, occupation, physical activities, dietary intake, noise, and air pollution, significant negative associations with the NDVI for the 250-meter buffer zone were found in total cholesterol (–21.6% per IQR increase in NDVI, 95% CI –32.7% to –10.6%), low-density lipoprotein (–14.9%, 95% CI –23.4% to –6.4%), glucose (–11.2%, 95% CI –21.9% to –0.5%), and high-sensitivity C-reactive protein (–41.3%, 95% CI –81.7% to –0.9%). Similar effect estimates were found for the 100-meter and 250-meter buffer zones. After adjustment for multiple testing, the effect estimates of glucose and high-sensitivity C-reactive protein were no longer significant.

CONCLUSIONS

The health benefits of green space can be found in some metabolic and inflammatory biomarkers. Further studies are warranted to establish the causal relationship between green space and cardiorespiratory health.

CLINICALTRIAL
Mining Trends of COVID-19 Vaccine Beliefs on Twitter With Lexical Embeddings: Longitudinal Observational Study (Preprint)
Authors: Chopra Harshita , Vashishtha Aniket , Pal Ridam , Ashima Ashima , Tyagi Ananya , Sethi Tavpritesh
Published: November 2021

BACKGROUND

Social media plays a pivotal role in disseminating news globally and acts as a platform for people to express their opinions on various topics. A wide variety of views accompany COVID-19 vaccination drives across the globe, often colored by emotions that change along with rising cases, approval of vaccines, and multiple factors discussed online.

OBJECTIVE

This study aims to analyze the temporal evolution of different emotions and the related influencing factors in tweets belonging to 5 countries with vital vaccine rollout programs, namely India, the United States, Brazil, the United Kingdom, and Australia.

METHODS

We extracted a corpus of nearly 1.8 million Twitter posts related to COVID-19 vaccination and created 2 classes of lexical categories—emotions and influencing factors. Using cosine distance from selected seed words’ embeddings, we expanded the vocabulary of each category and tracked the longitudinal change in their strength from June 2020 to April 2021 in each country. Community detection algorithms were used to find modules in positive correlation networks.

RESULTS

Our findings indicated the varying relationship among emotions and influencing factors across countries. Tweets expressing hesitancy toward vaccines represented the highest mentions of health-related effects in all countries, which reduced from 41% to 39% in India. We also observed a significant change (P<.001) in the linear trends of categories like hesitation and contentment before and after approval of vaccines. After the vaccine approval, 42% of tweets coming from India and 45% of tweets from the United States represented the “vaccine_rollout” category. Negative emotions like rage and sorrow gained the highest importance in the alluvial diagram and formed a significant module with all the influencing factors in April 2021, when India observed the second wave of COVID-19 cases.

CONCLUSIONS

By extracting and visualizing these tweets, we propose that such a framework may help guide the design of effective vaccine campaigns and be used by policy makers to model vaccine uptake and targeted interventions.
Exploring the Reasons for Low Cataract Surgery Uptake Among Patients Detected in a Community Outreach Program in Cameroon: Focused Ethnographic Mixed Methods Study (Preprint)
Authors: Mbwogge Mathew , Nkumbe Henry Ebong
Published: November 2021

BACKGROUND

Vision 2020: The Right to Sight, was one potential way to deal with the barriers surrounding cataract surgery and improve access to eye care. To this effect, the Magrabi International Council of Ophthalmology (ICO) Cameroon Eye Institute (MICEI) has performed more than 1000 sight-restoring cataract surgeries among patients referred from outreach camps. However, quite a good number of patients diagnosed with cataracts during community screening camps fail to present for surgery. This study sought to explore some of the challenges to accepting cataract surgery among community-diagnosed patients with cataract, patients operated for cataract, and community members.

OBJECTIVE

The study objective was 5-fold: (1) to assess the level of awareness about cataract and available treatment, (2) to explore barriers to cataract surgery uptake, (3) to assess people’s perception about the outcome of cataract surgery, (4) to understand people’s perception about free cataract surgery, and (5) to explore reasons for outright refusal of cataract surgery.

METHODS

This was a focused ethnographic study from December 2018 through February 2019 in 3 different communities of the Center Region of Cameroon, in which patients with cataract were diagnosed. The study sample was composed of patients operated for cataract, those diagnosed with cataract, key informants, and community members. Focus group discussions (FGDs), personalized in-depth interviews, and a short demographic questionnaire were used to collect data. Data were analyzed using a Microsoft Excel spreadsheet and Stata 14 (StataCorp). Data were presented using tabular and graphical methods.

RESULTS

A total of 29 subjects (19 men) with a mean age of 54.5 (SD 14.5) years took part in the study. The most prominent barriers to cataract surgery were found to be cost (25/29, 86%) and fear of surgery (17/29, 59%). It was also noted by 41% (12/29) of subjects that those who do not take up cataract surgery turn to traditional medicine. Other barriers included the lack of awareness of available treatment (6/29, 21%), no perceived need (5/29, 17%), cultural beliefs and superstition (4/29, 14%), and negligence (4/29, 14%).

CONCLUSIONS

We found cost (25/29, 86%) and fear (17/29, 59%) to be the main barriers. Belief in traditional medicine and superstition were the main drivers of fear. The implementation of a tiered pricing system, counseling training for key informants, incentives for the referral of patients with cataract, mass media engagement, advocacy, training and active involvement of traditional doctors as key informants, acquisition of a 4×4 outreach van, and motorbikes for camp organizers were some of the recommendations based on our results.
Development and Validation of the Adolescent Media Health Literacy Scales: Rasch Measurement Model Approach (Preprint)
Authors: Fleary Sasha A
Published: November 2021

BACKGROUND

High media use has been implicated in negative social and health outcomes among adolescents. Therefore, it is critical that adolescents develop skills to healthily engage with media content. Media health literacy (MHL), skills for assessing and responding to health-related media content, and potentially targetable moderators for the relationship between media use and health-related outcomes are understudied in adolescents. The lack of MHL assessment tools may have contributed to this research gap.

OBJECTIVE

This study aimed to develop and validate test-based scales of adolescents’ MHL.

METHODS

The items developed were vetted iteratively via community reviews and cognitive interviews to establish content and face validity. Adolescents (N=355) completed a questionnaire that included the revised MHL items. The scales (Recognition/Identification, Influence/Critical Analysis, and Action/Reaction) were validated using Rasch measurement models. Convergent validity was assessed by correlating the summed scores of the three scales with existing functional and internet-related health literacy measures. Criterion validity was assessed by modeling logistic regressions for predicting health literacy–related behaviors from each scale after controlling for demographics. Effect sizes were estimated, and a short form was also validated.

RESULTS

The final MHL scales (Recognition/Identification, Influence/Critical Analysis, and Action/Reaction) fit their Rasch models. The 9-item Recognition/Identification and 9-item Influence/Critical Analysis scales had good convergent validity with functional and internet-related health literacy measures and were positively related to reading instructions before taking medicines and questioning the truthfulness of health information found online. The 12-item MHL Scales-Short Form also had good convergent and criterion validity. However, convergent and criterion validity were not established for the 3-item Action/Reaction Scale.

CONCLUSIONS

The Recognition/Identification and Influence/Critical Analysis scales and the MHL Scales-Short Form may be used to determine the impact of MHL on media use and health outcome relationships and ultimately inform the development of interventions and policies to affect these relationships in multiple settings.
Techne’s Twofold Effects: Revelation and Manifestation as Factors in Its Practical Applications
Authors: Rivers Theodore John
Published: November 2021

Although it might be said that techne describes a mechanism that concerns all practical endeavors, it could also be said that the result of techne’s twofold effects concern the being of reality. Regardless of how reality is conceived, it may be described as the convergence of humanity (subjects) and the world (objects) within the context of the former’s practicality that indicates a process of becoming. The first of these effects concerns the idea of revelation that is essential as the cause of any manifestation, and the second of these effects concerns manifestation as the fulfillment of any revelation. Nevertheless, revelation is more important because not only is it a cause, it is also demonstrative of a process in which manifestation occurs. Due to the difference between these two effects, this mechanism is indicative of the innate relationship between what is (being) and what could be (becoming) from neither (non-being). Techne contains an intensity of far-reaching possibilities that reveals and manifests a process of becoming that is projected, when practically applied, as the purpose of its being. In this sense, it is the seminal word for any technological endeavor.
КОНСТРУКЦИЯ И ТЕХНОЛОГИЯ ИЗГОТОВЛЕНИЯ ДЕТЕКТОРА ОДИНОЧНЫХ ФОТОНОВ НА БАЗЕ ЛАВИННОГО ФОТОДИОДА INP / INGAAS / INP ДЛЯ КВАНТОВЫХ КОММУНИКАЦИЙ
Authors: Преображенский В.В. , Чистохин И.Б. , Путято М.А. , Валишева Н.А. , Емельянов Е.А. , Петрушков М.О. , Плешков А.С. , Неизвестный И.Г. , Рябцев И.И. , Латышев А.В.
Published: November 2021

Разработан и изготовлен детектор одиночных фотонов на базе лавинных фотодиодов (ОЛФД) InP / InGaAs / InP, работающих на длине волны 1550 нм. Приведено описание конструкции, способа получения гетероструктуры и изготовления чипа ОЛФД. Представлены предварительные результаты измерений параметров изготовленных ОЛФД.
АНАЛИЗ НЕМАРКОВСКОЙ КВАНТОВОЙ ДИНАМИКИ МЕТОДАМИ МАШИННОГО ОБУЧЕНИЯ
Authors: Лучников И.А. , Киктенко Е.О. , Гавреев М.А. , Уэрдан Х. , Филиппов С.Н. , Федоров А.К.
Published: November 2021

Разработан алгоритм для идентификации модели немарковской квантовой динамики по наблюдаемым данным. Отличительными особенностями нового алгоритма являются:;сходимость к оптимальному решению с математическими гарантиями;;автоматический подбор модели;;масштабируемость;;интерпретируемость.
АНАЛИЗ "ЛОЖНЫХ" ОШИБОК DRC ПРИ РЕГРЕССИОННОМ ТЕСТИРОВАНИИ КОМАНДНЫХ ФАЙЛОВ
Authors: Загидуллина О.Р. , Надин А.С.
Published: November 2021

В работе предложен метод анализа и последующей фильтрации «ложных» результатов регрессионного тестирования, возникающих из-за сдвига базы данных САПР для физической верификации при регрессионном анализе DRC deck и аттестации новых версий САПР.
РАЗРАБОТКА УНИВЕРСАЛЬНОГО ЦИФРОВОГО ТЕСТЕРА НА ОСНОВЕ ПЛИС
Authors: Максимов А.К.
Published: November 2021

Разработан формат описания временных диаграмм, подходящий для работы как с последовательными, так и с параллельными цифровыми интерфейсами. Сформулирована общая концепция построения конфигурации ПЛИС для работы с созданным форматом файлов.