bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of the chronic toxicity of the disinfectant drug Iodopovidone
Authors: Shevchenko O. , Zasyekin D.
Published: September 2023

The article reflects the results of preclinical studies of the chronic toxicity of the disinfectant drug Iodopovidone on non-linear laboratory white rats. Disinfectant Iodopovidon produced by LLC "Basalt" (Ukraine) is a polymer complex of iodine in its composition. The purpose of our research was to establish the chronic toxicity of the new promising disinfectant drug Iodopovedon. The experiment was conducted on the basis of the laboratory and clinic "Vetmedservis" of the Faculty of Veterinary Medicine of the National University of Life and Environmental Sciences of Ukraine on non-linear laboratory white rats in compliance with biotic norms in accordance with the Law of Ukraine "On the Protection of Animals from Cruelty" and the "European Convention on the Protection of Domestic Animals". 10 animals were involved in the experiment (5 animals - experimental and 5 animals - control), groups were formed according to the principle of analogues. Biochemical indicators of blood serum (total protein, albumins, globulins, glucose, urea, creatinine and activity of enzymes AsLT, AsAT), hematological indicators of blood and organ mass ratio (liver, kidneys, heart) were determined. Determinations were made in accordance with generally accepted methods. As a result of the study of biochemical indicators, a difference in the levels of total protein between the experimental and control groups was established within 2.1% due to a decrease in the level of the globulin fraction by 0.3% and a decrease in the level of the albumin fraction by 3.7% and a tendency to lower glucose levels by 28.0%. There was also a trend of an increase in AST activity by 7.3% and a decrease in ALT activity by 3.3%. The level of creatinine did not undergo pronounced changes against the background of an increase in the level of urea by 11.7%. When examining hematological indicators, a slight decrease in the number of lymphocytes by 6.6% and an increase in monocytes and granulocytes by 5.5 and 13.6% were found, respectively. The established changes in biochemical indicators of blood serum and hematological indicators of blood are insignificant and unlikely. The results of studies of the relative mass of internal organs - liver, kidneys and heart, to the final body mass of animals, indicate the absence of deviations. Therefore, the disinfectant preparation Iodopovidon does not cause pronounced changes in the critically important organs of the liver, kidneys and heart, does not cause pronounced changes in the morphological parameters of the blood of animals, the biochemical composition and activity of enzymes in the blood serum of white laboratory rats.
Key words: disinfectant, Iodopovidone, polymeric iodine complex, chronic toxicity, laboratory rats.
Analysis of the prevalence of osteoarticular pathologies in horses based on the results of radiography
Authors: Aharkova K. , Sliusarenko D. , Novytskyi V.
Published: September 2023

This article provides an overview of the literatureand recent scientific research on the spread of bone andjoint pathology among horses. Reasoned relevance andprospects of research on this issue.The article also presents the results of own research aimed at analyzing the distribution of bone andjoint diseases in horses on the territory of equestriansports clubs of Kharkiv region, Poltava region andKyiv region with the aim of finding out the frequencyof occurrence of this group of pathologies.To achievethe goal, radiography of 40 heads of horses aged 8-21years of riding breeds, which had signs of lamenessof the resisting limb, was carried out. Based on theresults of the research, differential diagnosis of boneand joint diseases was carried out. Differential diagnosis of arthrosis was presented taking into account thepathological process and its localization. According tothe obtained data, arthrosis accounted for 55% of thetotal number of studied animals, osteoporosis – 25%,periostitis – 7.5%, cystic formations and bone cracks –7.5%. Bone and joint pathology was not detected in theremaining 5%. Arthritic phenomena were localized inthe joints of the distal part of the limbs, namely: hoof,coronal, putative, carpal and hock. A case was registered when the degenerative process was concentratednot only in one joint, but also moved to the lower one.Among 55% of arthrosis, there were cases of osteoarthrosis, exfoliative osteochondritis, presence of ossification within the joint. The article also comparesown results with data obtained by foreign researchersregarding the distribution of bone and joint pathologiesin horses.In addition, the article substantiates the feasibilityof analyzing the spread of bone and joint diseases inhorses and demonstrates the effectiveness of X-ray diagnostics of these pathologies.
Key words: arthrosis, periostitis, osteoporosis, osteoarthritis, osteoarthritis of the hock joint, osteochondritis dissecans, ossification.
Clinical-radiological, hematological and biochemical assessment of bone replacement with germanium-doped calcium-phosphate ceramics for fragment fractures of tubular bones in dogs
Authors: Todosiuk T. , Rublenko M.
Published: September 2023

Abstract. Among surgical pathology in animals, asignificant share is occupied by various traumatic injuries of the skeleton, the consequence of which are bonefractures. The results of X-ray and biochemical indicators of blood for bone fragment fractures in dogs arepresented.The purpose of the work is to clinically, radiologically, and pathochemically justify bone replacementwith germanium-doped calcium-phosphate ceramicsfor bone fragment fractures in dogs.In the injured animals of the experimental group(n=10), bone defects were replaced with germanium-doped calcium-phosphate ceramics (ГТлГег-700),in the control group (n=10) with unalloyed ceramics(ГТг-700). The activity of total alkaline phosphatase (ALP)and its bone isoenzyme (KiLP), tartrate-resistant acidphosphatase (TrKF) was determined in blood serum.Measurements were made with a Stat Fax 4500 spectrophotometer.On the 60th day, in the animals of the experimentalgroup, the filling of the bone defect with regeneratedmaterial of high X-ray density was noted, with the absence of periosteal reaction, which indicated the complete consolidation of the fracture and was the reasonfor the removal of the means of fixation. In the control,the area of the bone tissue defect that was not filledwith regenerate was visualized.The activity of tartrate-resistant acid phosphatase(TRP) in both groups tended to increase. On the 14th day,the animals of the experimental group had a peak activity of TrKf (33.8±0.31), which was 1.3 times (p<0.001)higher than the level in the control group and 1.5 times(p<0.001) of clinically healthy animals, respectively. Onthe 30th day of research, a 1.2-fold (p<0.001) decreasein the level of TrCF was noted in the experimental groupcompared to the control group, in which the indicatorreached peak values at 34.9±0.25 units/l.The maximum activity of the bone isoenzyme alkaline phosphatase (KiLF) in the experimental groupwas observed on the 14th day of reparative osteogenesis and was 41.7±0.43 units/l, which is 1.2 times(p<0.001) higher than the indicator of the controlgroup. On the other hand, in the last group, the peakactivity of the bone isozyme was noted only on the30th day (40.9±0.48 units/l), while the indicator of theexperimental animals decreased dynamically duringthis period.The use of calcium-phosphate ceramics for fragment fractures of the bones of the tibia in dogs helpsto reduce the intensity of the inflammatory-resorptivestage of reparative osteogenesis and accelerates consolidation by 1.4 times. The dynamics of biochemicalmarkers of bone metabolism testifies to the optimizedcourse of reparative osteogenesis during osteoreplacement of bone defects with germanium-doped calcium-phosphate ceramics.
Key words: bioceramics, germanium, total alkaline phosphatase, bone isoenzyme of alkaline phosphatase, tartrate-resistant acid phosphatase, bonetissue.
Rationale and efficacy of sexual desire stimulation in mares under anaphrodisia
Authors: Ordin Y. , Ivasenko B. , Yeroshenko O.
Published: September 2023

Data from the literature regarding the objectivity of clinical and hormonal methods of diagnosing disorders of the gonads are contradictory, because they do not always accurately reflect the state of the course of folliculo-luteogenesis. At the same time, the relationship between clinical and endocrine indicators is still insufficiently clarified, which does not allow for the development of a justified use of drugs that accelerate the manifestation of sexual hunting in mares. In this regard, our further studies were aimed at studying the dependence of hormonal indicators on the size, shape and consistency of the gonads and determining the effectiveness of stimulation of sexual hunting with prostaglandin F 2α drugs. Before conducting the experiment, it was taken into account that exogenous prostaglandin F-2 alpha has both luteolytic properties - causes lysis of the corpus luteum, and stimulating properties - affects the release of gonadotropin hormones (FSH, LH) by the hypothalamus and pituitary gland, which leads to an acceleration of the manifestation of phenomena arousal stage of the sexual cycle. From the data presented in the article, it can be seen that after the use of estrophan sexual desire was found in a larger number of animals than when bioestrophan was administered and in the control. It was observed that the effectiveness of bioestrophan compared to estrophan was lower according to some parameters: 29% of animals showed less desire for sex, its duration was 1.5 days longer (8.2±1.6 vs. 6.7±0.6), and fertilization is 19% lower. The reaction of the animals to the administration of the drugs in terms of the period from administration to the manifestation of potential libido (desire with clear signs) was almost the same (7.0±1.8 and 7.3±1.2 days). The effectiveness of prostaglandin F-2 alpha preparations, applied to mares with anaphrodisiacs to stimulate the onset of the arousal stage of the sexual cycle, depends on the value of IPRYA (the value of the integral indicator of the size of mare's ovaries), which characterizes the activity of the gonads and their refractoriness to exogenous prostaglandins. With a large value of IPRYA - 14–18 cm, compared to the control, the introduction of estrophan and bioestrophan increased the number of mares that showed sexual desire by 47.5 and 27%, accelerated the onset of sexual hunting by 9 and 8 days, contributed to an increase in fertilization by 43 and 30%. Based on the above, the PI of mare's ovaries can be used to clarify the diagnosis - hypofunction and persistence of the corpus luteum of the gonads.
Key words: sexual cycle, sexual desire, exogenous prostaglandin F-2 alpha, anaphrodisia, infertility, mares.
Examination of urine microflora and resistance of isolated pathogens during inflammatory processes of the urinary tract in dogs
Authors: Rublenko I. , Chemerovska I. , Bolibrukh M. , Taranuha S. , Nasarenko M. , Rublenko S.
Published: September 2023

Antibiotic-resistant bacteria are currently frequently isolated from pets and farm animals. The long-term irrational use of antibiotics for the treatment of animals and humans is underestimated and requires further attention and research, including in Ukraine. The aim of our study was to identify bacterial isolates and study their sensitivity to antibiotics in urinary tract inflammation in dogs. According to the statistical data of the VetForce system of the BTNAU clinic, out of 202 dogs examined in the clinic, 15 (7.43 %) were diagnosed with diseases with signs of urinary tract inflammation. It has been established that a large number of microorganisms, mainly E. coli, Streptococcus urinae, Pseudomonas aeruginosa and Staphylococcus aureus, causes inflammatory processes of the urinary tract in dogs. A less common microorganism, Klebsiella pneumonia, proved to be resistant. It was found that bacterial cystitis (the first group of animals) prevailed 1.5 times more often than in animals with urolithiasis. In dogs of the first group of 6–12 years old and over 12 years old, the percentage of the disease was higher compared to the group from 0.6 to 1.6 years old by 10.2 and 22.2 %, respectively. Dogs of the second group, aged 1.6–12 years, suffering from urolithiasis (66.6 %), suffer from bacterial diseases 4 times more often compared to animals aged 0.6–1.6 years. Streptococcus urinae, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were isolated and identified from the urine of dogs in this group. In the associated form, E. coli and Streptococcus pyogene predominated in the urine of dogs. A resistant strain of Klebsiella pneumonia to amoxicillin, streptomycin, kanamycin, gentamicin and tetracycline was identified. Antibiotics should be used rationally, taking into account that for the treatment of animals it is necessary to determine the sensitivity of the pathogen with which the animal was infected. Antibiotic therapy should be carried out until complete elimination, which is sometimes achieved through prolonged treatment.
Key words: microorganisms, distribution, pathogens, urine, dogs, resistance, antibiotics, urinary tract, bacteriological testing.
Antibiotic resistance of isolates of Staphylococcus spp. and Streptococcus spp. causing mastitis on dairy farms in Ukraine
Authors: Shevchenko M. , Andriichuk A.
Published: September 2023

Mastitis is the most common pathology of cows that causes large economic losses to dairy farms. Mastitis is often caused by a group of infectious associated pathogens that can be transmitted among animals. Most often, the pathological process in subclinically and clinically sick animals is caused by coccal gram-positive microflora. A major problem is the mechanisms by which microorganisms acquire resistance to one or more antibacterial agents. Thus, standard treatment regimens used on the farm become ineffective. The publication presents the results of the study of antibiotic resistance of 45 isolates of Staphylococcus spp. and 22 isolates of Streptococcus spp. In this study, the chromogenic media CHROMagarTM Mastitis, CHROMagarTM Orientation and CHROMagarTM MH Orientation were used, which helped to speed up the isolation and identification of cultures. Phenotypic antibiotic resistance profiles were determined using the agar diffusion method. Staphylococcus aureus and coagulase-negative Staphylococcus (CoNS) showed a high level of resistance to beta-lactams of the penicillin class of benzylpenicillin – 60% and 66.7%. Streptococcus disgalactiae and Streptococcus agalactiae showed high resistance to tetracycline – 46.7% and 35.3%. At the same time, Streptococcus agalactiae had a high resistance to clindamycin of 35.3%. Streptococcus disgalactiae to benzylpenicillin – 29.4%, Streptococus uberis to clindamycin – 75%. The lowest resistance was observed to the antibiotic vancomycin in 6.7% of isolated staphylococci and 13.3% of streptococci. MAR index of more than 0.2 was observed in 75% of Streptococus uberis, 60% of CoNS and 52.9% of Streptococcus agalactiae. More than 50% of all studied isolates had multiple resistance to antibiotics most commonly used on Ukrainian farms.
Key words: Streptococcus spp., Staphylococcus spp., antibiotic resistance, mastitis, infectious mastitis, gram-positive bacteria.
Inheritance and transgressive variability of the number of grains per ear in F1 – F2 soft spring wheat
Authors: Khakhula V. , Lozinska T. , Hornovska S. , Mykhailiuk D. , Krupa N.
Published: September 2023

The research was conducted in the experimental field of Bila Tserkva NAU with reciprocal F1 – F2 hybrids obtained from crossing modern soft spring wheat varieties of different genealogical origin: Elehiia Myronivska, Simkoda Myronivska, Struna Myronivska, Kollektyvna 3, Heroinya, Leguan, Azhurnaia. The standard variety was Elehiia Myronivska. The research program included the study of the nature of inheritance in F1 of the number of grains in the main spike and the establishment of the degree and frequency of transgressions in F2 in order to identify valuable breeding material for this trait. According to the trait "number of grains per ear", we identified hybrid combinations with high performance: Struna Myronivska/Simkoda Myronivska (52.7 pcs.) and Struna Myronivska/Elehiia Myronivska (51.8 pcs.). It was found that the inheritance of the number of grains in the ear in the studied hybrids was of the type of positive superdominance, the degree of dominance in direct crosses was in the range from +1, 9 in the hybrid combination Struna Myronivska/Heroinya to +87.0 in Struna Myronivska/Leguan, and in reciprocal crosses it ranged from +3.4 in Simkoda Myronivska/Struna Myronivska to +62.3 in Leguan/Struna Myronivska. The smallest range of variability in the number of grains in the ear is characterized by the hybrid combination Struna Myronovska/Azhurnaia (15 pcs.) with a variance index of 27.1. Indicators of coefficients of variation characterize F1 as an active formative process on the basis of the trait "number of grains in the ear". In F2 transgressive forms were identified in the combinations of crosses Heroinya/Struna Myronivska, Struna Myronivska/Elehiia Mironovska and Kollektyvna 3/Struna Myronivska, the degree of transgression of which was 51.4, 45.6 and 39.4 % at a frequency of 68.1, 38.6 and 14.4 %, respectively. It has been proved that the results of transgressive variability can increase the diversity of the soft spring wheat gene pool and provide valuable selection material.
Key words: spring wheat, number of grains of the main ear, inheritance, variability, transgressions, adaptability, productivity.
Yield and quality of Panicum virgatum (Panicum virgatum L.) seed depending on varietal characteristics
Authors: Dryga V. , Doronin V. , Shcherbynina N. , Skhlyar V.
Published: September 2023

The article presents the results of research on millet seeds the crop formation and the quality, depending on its varietal characteristics. It was experimentally proven that in the conditions of the Right Bank Forest-Steppe of Ukraine, the passage of phenological phases of growth and development of millet depended both on varietal characteristics (groups of varietal maturity) and on the number of effective temperatures. The crop yield and quality depended on the phenological phases of growth and development, particularly the phases of ﬂowering and seed formation and their conditions. On average, over three years, early and late ripening varieties had signifcantly lower seed yield compared to other variety samples. Early-ripening, mid-early and mid-late varieties had signifcantly higher seed yield. The lowest productivity was in the very early sample of Dakota – 88.3 kg/ha. The yield of very late varieties – Nezalezhnist, Kanlow and Lyadivske – made 89.7, 88.3 and 99.4 kg/ha, respectively. The study on factors affecting seed yield established that the inﬂuence of the factor "variety" was the largest and amounted to 61.1 %, and the factor of "growing conditions" affected the crop less – 11.9 %. Germination energy and seed germination, as well as its yield, depended on the maturity groups of the variety samples. Very early, early-ripening and medium-ripening varieties had the highest quality indicators, no signifcant difference was found depending on varietal characteristics. The mid-late varieties had signifcantly lower quality indicators, and the lowest quality was the very late Kanlow variety. The study on factors affecting seed quality established that the inﬂuence of the "year conditions" factor on germination energy and germination was the greatest and was 37.6–48 %, and the "variety" factor was 33.8 and 30 %, respectively. It was found that the later is the variety is of the maturity group, the higher is the sum of effective temperatures it needs and, accordingly, the longer the onset of the phenological phases of growth and development of the crop, which affects the features of seed formation and ripening and, accordingly, its quality and yield. The mid-late varieties had signifcantly lower quality indicators and the lowest ones were observed in the very late variety. Mid-late, late and very late varieties do not ripen biologically, which affects the seeds quality its germination is very low.
Key words: variety samples, maturity groups, germination energy, germination, phenological phases of growth and development.
Determination of winter rapeseed (Brassica napus L.) polymorphism based on SSR markers and morphological characters
Authors: Piskova O. , Kostenko A. , Shliakhtun I. , Dikhtiar I. , Ilchenko Y. , Prysiazhniuk L.
Published: September 2023

The study presents the results of the genetic diversity estimation of winter rapeseed by molecular genetic analysis and the determination of polymorphism with morphological traits. The study aims to determine winter rapeseed hybrids polymorphism by SSR markers and the marker morphological characteristics. Twelve winter rapeseed hybrids which were examined within DUS testing and their 24 hereditary components were studied in 2021–2022. The study of rapeseed genotypes genetic diversity was carried out in 2021. It was determined that the majority of studied hybrids and their hereditary components by studied SSR markers are characterized with alleles of the same sizes and are homozygotic by these markers. Besides, it was found that the presence of only on one allele was identifed in hereditary components which was found in hybrids. This distribution allows to check the hybrid formula and to identify them. It was determined that the most polymorphic marker was Na12-A02, PIC is 0.77. The lowest value of PIC was obtained for Na12-E02 marker (0.47). On the average, for studied markers PIC is 0.66 which indicates the evenness of identifed alleles distribution by SSR markers among studied winter rapeseed genotypes. As results of cluster analysis, we obtained fve clusters of the studied hybrids by 8 SSR markers. The hybrids with genetic distances of 2.45 were the most similar hybrids. It was found that the hybrids with genetic distances of 5.83 and 5.74 were the most distinct. Three clusters were obtained as results of the cluster analysis based on morphological traits. It was determined that the most similar hybrids were the ones with genetic distances of 3.46. It was found that the most distinct hybrids had the genetic distances of 5.299.38. Thus, taking into account the various distribution of the studied genotypes by the SSR markers and morphological characteristics, SSR markers can be used as additional tool for the distinctness determination.
Key words: genetic distances, winter rapeseed, allele frequencies, РІС, genetic diversity, SSR markers.
Economic and energy efciency of fungicides and microfertilizers in the cultivation of sugar beet hybrids
Authors: Potapov A. , Grabovskiy M.
Published: September 2023

The results of determining sugar beet hybrids economic and energy efciency technology growing depending on the use of fungicides and microfertilizers are presented. The research was conducted in 2020–2022 in the “Svitanok” Agrienterprise of Vasylkiv district, Kyiv region. Research was conducted with two sugar beet hybrids (Pushkin, Akatsia), three variants of microfertilizers (control, YaraVita Bortrac 150 (3 l/ ha), YaraVita Mancozin (1 l/ha)) and three schemes of fungicide application (Stefstrobin (0.6 l/ha) + Shtefozal (0.5 l/ha) + Shtilvet (0.1 l/ha); Tserkostef (0.5 l/ha) + Shtefstrobin (0.6 l/ha) + Shtilvet (0.1 l/ha); Cerkoshtef (0.5 l/ha) + Shtefozal (0.5 l/ha) + Shtilvet (0.1 l/ha )) were studied. The evaluation of the fungicides and microfertilizers economic efciency was determined according to the prices for the end of 2022 according to generally accepted methods. The technology of sugar beets growing is generally accepted for the zone of the Right Bank Forest Steppe, except for the methods that were put to study. It was established that in the structure of economic costs during the cultivation of sugar beets, a signifcant part is occupied by the use of mineral fertilizers – 23.7 %, fuel – 18.6 %, plant protection products – 16.3 %, seeds – 13.5 %. In the structure of energy costs, most of it belongs to fuel (27.8 %), mineral fertilizers (26.9 %), equipment (19.7 %) and labor costs (15.7 %). Energy costs for plant protection products and microfertilizers make 4.5 and 0.7 %. The Akatsia hybrid has higher proftability rates (53245.7 UAH/ha), proftableness (164.9 %) and energy efciency ratio (3.6) compared to the Pushkin hybrid (45462.2 UAH/ha, 147.6 % and 3.3). From an economic and energy point of view, the combined use of microfertilizers YaraVita Mancozin (1 l/ha) and fungicides Tserkoshtef, k. s. (0.5 l/ha) + Stefstrobin k.s. (0.6 l/ha)+ Stilvet (0.1 l/ha) is the most appropriate. Efciency, proftability and energy efciency ratio were 51491.3 and 60394.3 UAH/ha, 161.9 and 181.5 %, 3.58 and 3.94, respectively, for hybrids Pushkin and Acacia.
Key words: sugar beets, fungicides, microfertilizers, hybrids, economic efciency, energy efficiency.
PEMERATAAN DAN KEADILAN EKONOMI DI INDONESIA (PERSPEKTIF EKONOMI SYARIAH)
Authors: Amin Darwis
Published: September 2023

AbstractsThis study aims to understand the equitable distribution of the economy in Indonesia and to look at the Islamic economic perspective on economic justice in the context of economic equality in Indonesia. This type of research is library research with analysis tools using the Gini coefficient, Theil index, L index and the World Bank. The results of the study show (1) There is still inequality in the distribution of the economy in Indonesia because there is a significant increase in the wealth of capital owners, while workers only have capital in the form of labor and skills. (2) In the context of economic equality in Indonesia, the Islamic perspective puts forward the concept of economic distribution that covers the entire Indonesian economic system with the principle of economic justice according to Islamic teachings.Keyword: economic equity, economic justice, gini ratio, Theil index, L index AbstrakPenelitian ini bertujuan untuk memahami distribusi ekonomi yang merata di Indonesia serta melihat perspektif ekonomi Islam mengenai keadilan ekonomi dalam konteks pemerataan ekonomi di Indonesia. Jenis penelitian merupakan penelitian kepustakaan dengan alat analisis menggunakan koefisien gini, indeks Theil, indeks L serta Bank Dunia. Hasil penelitian menunjukkan (1) Masih terjadi ketimpangan dalam pendistribusian ekonomi di Indonesia karena terdapat peningkatan yang signifikan dalam kekayaan pemilik modal, sedangkan pekerja hanya memiliki modal berupa tenaga kerja dan keterampilan. (2) Dalam konteks pemerataan ekonomi di Indonesia, perspektif Islam mengemukakan konsep distribusi ekonomi yang mencakup seluruh sistem ekonomi Indonesia dengan prinsip keadilan ekonomi menurut ajaran Islam.Kata Kunci: pemeratakaan ekonomi, keadilan ekonomi, gini rasio, indeks Theil, indeks L
APAKAH PERTUMBUHAN PENDUDUK BERDAMPAK BAGI PERTUMBUHAN EKONOMI KABUPATEN SOLOK
Authors: Wirda Fisla , Putra Trimardi Jaya , Wardani Rahmi , Herizon Herizon
Published: September 2023

AbstractsThis study analyzes the effect of population growth on economic growth in the Solok district. The data used in this study is secondary data in the form of economic growth and population growth of Solok Regency from 2011 to 2022. This data was released by the Central Statistics Agency (BPS) of Solok Regency. Data analysis was performed using simple Regression. The results showed that: Y=-2.158" + 81.832X with a sig value of < 0.05; This means that population growth has a positive and significant effect on economic growth. An r value of 0.910 indicates a strong correlation between population and economic growth. A relationship is vital if the value of r is close to 1.Keywords: Population growth; economic growth; Solok district; simple regression  AbstrakPenelitian ini menganalisa pengaruh pertumbuhan penduduk terhadap petumbuhan ekonomi di kabupaten Solok.  Data yang digunakan dalam penelitian ini adalah data sekunder berupa pertumbuhan ekonomi dan pertumbuhan penduduk Kabupaten Solok dari tahun 2011 sampai dengan tahun 2022. Data ini diterbitkan oleh Badan Pusat Statistik (BPS) Kabupaten Solok. Analisis data dilakukan dengan menggunakan Regresi sederhana. Hasil penelitian menunjukkan bahwa: Y=-2,158" + 81,832X dengan nilai sig < 0,05; Artinya pertumbuhan penduduk berpengaruh positif dan signifikaan terhadap pertumbuhan ekonomi.  Nilai r sebesar 0,910 mengindikasikan korelasi yang kuat antara jumlah penduduk dengan pertumbuhan ekonomi. Suatu hubungan dikatakan kuat jika nilai r mendekati 1.Kata kunci: Pertumbuhan penduduk; pertumbuhan ekonomi; kabupaten Solok; regresi sederhana.
PERAN CITRA MEREK DAN KESADARAN MEREK SEBAGAI MEDIASI PENGARUH DIGITAL MARKETING TERHADAP KEPUTUSAN PEMBELIAN PADA KOPI TUNI MALUKU
Authors: Saidi Subhan Akbar , Asnawi R.A A , Huwae Victor Ernest
Published: September 2023

AbstractsThis research stems from the existence of phenomena in the research object and research gaps in previous studies. This research also has an update of brand image and brand awareness variables which act as mediating variables. On that basis, researchers develop a theoretical approach to fill the research gap and are expected to have a contribution to the development of science, especially management. The location of this research is located at the Maluku Coffee Foundation as the manager of Maluku Tuni Coffee. The data collection technique used purposive sampling by distributing questionnaires to 190 respondents. The data analysis technique used in this study is Amos' Structural Equation Modeling (SEM). The results of this study indicate that brand image and brand awareness as mediation have an indirect positive and insignificant effect on purchasing decisions, digital marketing has a direct positive and significant effect on brand image and brand awareness. Meanwhile, digital marketing has a negative and insignificant effect on purchasing decisions. Other results of brand image and brand awareness have a direct and not significant positive effect on purchasing decisions.Keywords: Digital Marketing, Brand Image, Brand Awareness and Purchase Decision AbstrakPenelitian ini bermula dari adanya fenomena pada objek penelitian dan research gap pada penelitian sebelumnya. Penelitian ini sekaligus memiliki pembaharuan dari variabel citra merek dan kesadaran merek yang berperan sebagai variabel mediasi. Atas dasar itu, Peneliti mengembangkan suatu pendekatan teatrikal guna untuk mengisi research gap tersebut dan diharapkan memiliki kontribusi terhadap perkembangan ilmu pengetahuan khususnya Manajemen. Lokasi penelitian ini bertempat pada Yayasan Kopi Maluku selaku pengelola Kopi Tuni Maluku.Teknik pengumpulan data menggunakan purposive sampling dengan menyebarkan kuesioner kepada 190 responden. Teknik analisis data yang digunakan dalam penelitian ini adalah  Structural Equation Modeling (SEM) Amos. Hasil penelitian ini menunjukkan bahwa citra merek dan kesadaran merek sebagai mediasi berpengaruh tidak langsung secara positif dan tidak signifikan terhadap keputusan pembelian, digital marketing berpengaruh langsung secara positif dan signifikan terhadap citra merek dan kesadaran merek. Sementara digital marketing berpengaruh negatif dan tidak signifikan terhadap keputusan pembelian. Hasil lainnya citra merek dan kesadaran merek secara langsung berpengaruh positif dan tidak signifikan terhadap keputusan pembelian.Kata kunci: Digital Marketing, Citra Merek, Kesadaran Merek, Keputusan Pembelian
PENGARUH FAKTOR SOSIAL DAN ETIKA DALAM PERILAKU PENGAMBILAN KEPUTUSAN INVESTASI: STUDI KASUS PADA INVESTASI KEUANGAN SYARIAH
Authors: Hamizar Arizal
Published: September 2023

AbstractThis study examines how ethical and social responsibility factors influence investment decision-making among Islamic finance investors. Utilizing a qualitative approach, an analysis of investors' perceptions and preferences regarding investment is conducted, connecting them with the principles of Islamic finance. The results of in-depth interviews with a diverse group of investors reveal that the principles of Islamic finance serve as a strong ethical guide in investment decision-making. Moreover, it is found that ethical and social responsibility values are increasingly playing a significant role in guiding the selection of investment instruments. The importance of ethics in Islamic finance investment is reflected in investors' emphasis on the principles of Islamic finance that prohibit usury, ambiguity, and gambling. However, the findings also uncover that investors are increasingly considering the social impact of their investments. Social responsibility is deemed a determinant factor in decision-making, with preferences tending to shift towards investment instruments that provide positive benefits to society and the environment.Keywords: Financial Investment, Islamic Finance, Consumer Behavior, Social, Ethics. AbstrakPenelitian ini mengkaji bagaimana faktor etika dan tanggung jawab sosial mempengaruhi pengambilan keputusan investasi di kalangan investor keuangan syariah. Dengan menggunakan pendekatan kualitatif, analisis mengenai persepsi dan preferensi investasi para investor dilakukan, serta menghubungkannya dengan prinsip-prinsip keuangan syariah. Hasil wawancara mendalam dengan beragam investor mengungkapkan bahwa prinsip-prinsip keuangan syariah menjadi panduan etika yang kuat dalam pengambilan keputusan investasi. Selain itu, ditemukan nilai-nilai etika dan tanggung jawab sosial semakin memainkan peran yang signifikan dalam memandu pemilihan instrumen investasi. Pentingnya etika dalam investasi keuangan syariah tercermin dalam penekanan investor terhadap prinsip-prinsip keuangan syariah yang melarang riba, gharar, dan maisir. Namun, temuan juga mengungkapkan bahwa investor semakin mempertimbangkan dampak sosial dari investasi mereka. Tanggung jawab sosial dianggap sebagai faktor penentu dalam pengambilan keputusan, dengan preferensi yang cenderung beralih ke instrumen investasi yang memberikan manfaat positif bagi masyarakat dan lingkungan.Kata Kunci: Investasi Keuangan, keuangan Syariah, Perilaku Konsumen, Sosial, Etika.
Transition metal doped phosphors for LEDs
Authors:   , van Bunningen Arnoldus Jacobus
Published: September 2023

The luminescence properties of various transition metal ions in inorganic host lattices have been studied in this thesis, with a strong emphasis on their temperature-dependent behavior also in relation with application as phosphors in white light LEDs for lighting and broad band NIR LEDs for sensing. The following paragraphs present an overview of the key results from each chapter. This is followed by an outlook on future research topics and challenges.
Chloride cotransport in the membrane of earthworm body wall muscles.
Authors: Volkov EM , Nurullin LF , Nikolsky E , Krůšek J , Vyskočil F
Published: September 2023

The resting membrane potential (Vm) of isolated somatic longitudinal muscles of the earthworm Lumbricus terrestris was studied by glass microelectrodes. The inhibition of chloride permeability by low pH did not affect Vm of the muscle fibers in isolated somatic longitudinal muscles of the earthworm Lumbricus terrestris which was –48.7 mV (inside negative) at pH 7.3 and –49.1 at pH 5.6. On the other hand, bathing the muscles in Cl- and Na+-free solutions, or application of the chloride transporter inhibitor furosemide and Na+-K+-ATPase inhibitor ouabain depolarized the Vm by 3-5 mV. The effects of a Cl- -free solution and ouabain were not additive. This demonstrates relatively small contribution of equilibrium potential for Cl- to the resting membrane potential and electrogenic effect of Na+K+-ATPase which is dependent on the supply of Na+i ions by furosemide-sensitive and Cl-e- and Na+e-dependent electroneutral transport (most probably Na+K+Cl- cotransport).
Short-term dynamics of coherence between respiratory movements, heart rate, and arterial pressure fluctuations in severe acute brain disorders.
Authors: Zwiener U , Schelenz Ch , Bramer S , Hoyer D
Published: September 2023

In our previous study, healthy volunteers showed considerable short-term dynamics and patterns of the coherence of high time resolution between respiratory movements (RESP), heart rate fluctuations (HRF), and arterial blood pressure fluctuations (BPF). These are physiological indicators of autonomic short-term coordination mediated mainly by the brainstem which could be impaired in severe brain disorders. We hypothesized a direct or indirect impairment of these functions by these disorders and examined these patterns in 16 patients suffering from severe brain disorders. We calculated partial and ordinary coherence sequences and found almost the same patterns of coherence sequences as in healthy volunteers, but a distinctly reduced frequency of pattern incidence in patients (2.8*1.5/10 min/patient and 9.5*2.8/10 min/subject, P<0.05). Furthermore, there is a significantly smaller frequency of HRF-related patterns in patients with poor outcome, compared with those in patients with good outcome (1.8*0.8/10 min/patient and 4.5*2.7/10 min/patient, P<0.05). We conclude that severe brain disorders reduce physiological short-term dynamics of autonomic coordination patterns in the mean values of patients, but not in every patient.
Infographic: The RDCN 2022 Annual Meeting
Authors: EMJ
Published: September 2023

This infographic provides an overview of the topics explored at the Rare Disease Connect in Neurology (RDCN) 2022 Annual Meeting, an educational programme organised and funded by UCB Biopharma SRL. RDCN is an inclusive educational programme designed for stakeholders involved in the care, management, and advancement of myasthenia gravis (MG). The RDCN community brings together MG specialists and those living with MG from across the globe to share insights and experiences in managing MG.
The infographic explores the three main topics discussed at the RDCN 2022 Annual Meeting: pathogenesis and diagnosis, clinical management, and patient care. Spotlighting the sessions in each of these topics, the infographic delves into the insights shared throughout the RDCN 2022 Annual Meeting programme.
Trimethylamine N-Oxide (TMAO): a Unique Counteracting Osmolyte?
Authors: Yancey Paul H.
Published: September 2023

Cells of many organisms facing osmotic shrinkage or swelling undergo homeostatic volume regulation using osmolytes—inorganic ions (Na+, K+, Cl-) in transient disturbances, but special organic osmolytes in long-term disturbances. Neutral amino acids, methylamines and polyols are key examples. Widely termed 'compatible' cosolutes/cosolvents, they—unlike inorganic ions—do not perturb membrane potential nor (supposedly) macromolecules. Indeed, most enhance protein stability in part through preferential exclusion; i.e., they 'dissolve' poorly in proteins' hydration layer and reduce water availability for hydrating unfolding proteins. However, these concepts imply that organic osmolytes are all 'compatible' and interchangeable in this way. Instead, most have unique non-osmotic cytoprotective properties such as antioxidation, and some may have stabilizing features not universal among osmolytes. The latter is exemplified by trimethylamine N-oxide (TMAO), an osmolyte high in chondrichthyans (sharks and rays), and that increases with depth in many marine animals. First, TMAO is the strongest enhancer of protein folding among common osmolytes, but unlike most osmolytes, exhibits some preferential binding with proteins. Second, unlike other common osmolytes such as glycine, TMAO is not found in nature in the absence of a protein destabilizer—notably urea (primary osmolyte of chondrichthyans) and hydrostatic pressure, both counteracted by TMAO. Without a destabilizer, TMAO can over-stabilize proteins causing non-functional aggregates; i.e., it is not 'compatible'. Third, TMAO 'hardens' water structure and reduces water compressibility (again unlike other osmolytes). Under high pressure in the deep sea, these 'piezolyte' properties reduce both protein unfolding and cell volume compression.
Compression Molding of Hybrid Continuous and Discontinuous Fiber Reinforced Thermoplastics for Enhancing Strength Characteristics
Authors: Barocio Eduardo , Eichenhofer Martin , Kalman Jordan , Fjeld Ludvik M. , Kirchhoff Joseph , Kim Garam , Pipes R. Byron
Published: September 2023

Compression molding with long discontinuous fiber-reinforced thermoplastics enables replacing traditionally machined metallic components with geometrical complexity and with reductions in weight and potential enhancements in structural characteristics like durability, fatigue, and serviceability. Fiber length is critical in fiber-reinforced composites. While long continuous fibers limit the geometrical complexity that can be fabricated but provide exceptional mechanical properties, discontinuous fibers provide manufacturing flexibility but with a penalty in strength. This work demonstrates enhancement in strength and reduction in strength variability achieved by compression molding of long discontinuous fiber platelets and continuous fiber preforms. This approach was demonstrated for an overhead bin pin bracket geometry. Continuous fiber preforms were manufactured with 60% by volume of carbon fiber-reinforced Poly Ether Ketone Ketone (PEKK) using the 9T Labs continuous fiber Additive Fusion Technology (AFT). Similarly, fiber platelets with 60% by volume of carbon fiber reinforced PEKK were utilized. Continuous fiber preforms were designed considering both the concurrent flow of continuous and discontinuous fibers with the desired mesostructure of continuous and discontinuous fibers. The results presented in this work showed an increase of 99.6% in the load at the onset of damage by reinforcing the pin bracket with about 17% by weight of continuous fiber preforms. Similarly, the coefficient of variance of the load at the onset of failure decreased by 46%. Finally, reinforcing the pin bracket with continuous fiber preforms not only enhanced the strength characteristics but also decreased the variability in strength characteristics.
YÜKSEK ŞİDDETLİ İNTERVAL ANTRENMANIN METABOLİK SENDROM ÜZERİNDEKİ ETKİSİ
Authors: ÇELENK DURGUT Büke , ESKİCİ Günay
Published: September 2023

Metabolik sendrom (MetS); insülin direnci, abdominal obezite, hiperlipidemi ve hipertansiyon ile karakterize bir durumdur. Metabolik sendromlu bireyler; diyabet açısından 2 kat ve kardiyovasküler hastalık açısından 5 kat artmış risk ile ilişkilendirilmiştir. Modern toplumların en büyük problemlerinden biri olan sedanter yaşam tarzı, birçok hastalık için risk faktörüdür. Fiziksel aktivite ve egzersiz yapmamak için farklı sebepler bulunsa da, en büyük engel genellikle zaman eksikliğidir. Daha kısa egzersiz ve dinlenme süreleriyle uygulanan antrenman programları, yeni bir yaklaşım sunmaktadır. Yüksek Şiddetli İnterval Antrenman (High Intensity Interval Training-HIIT), aralarına düşük yoğunluklu toparlanma periyotları serpiştirilmiş kısa aralıklı şiddetli egzersiz patlamaları ile karakterizedir. Bireysel ihtiyaçlara göre uyarlanan HIIT, çoğu egzersiz ortamında kullanılabilen egzersiz reçetelerini kapsar. Bu uyum yeteneği, HIIT'i kronik hastalığı olan kişilerin egzersiz programlamasında önemli bir araç haline getirmiştir. HIIT antrenmanları da MetS’li bireylerde sağlığı geliştirmiş, komplikasyonları azaltmıştır. MetS’li kişilerde HIIT her konuda Orta Şiddette Sürekli Devam Eden Antrenman (Moderate Intensity Continuous Training-MICT)’dan üstün bulunmamış ancak sağlığa benzer faydalar sağladığı belirlenmiştir. HIIT zaman tasarrufu açısından MICT’e göre avantajlıdır. Modern toplumlarda en önemli eksikliğin zaman olduğu düşünülürse HIIT bu yönüyle ön plana çıkar. HIIT’in kontraendike olduğu (kontrol altına alınamayan kardiyovasküler hastalık vb.) veya yapılamadığı dönemlerde MICT tercih edilebilir ve sağlığı iyileştirici benzer etkiler gösterir. HIIT antrenmanları klinik popülasyonda dikkatle reçetelendirilmeli ve kesinlikle bireye özgü olmalıdır. Bu konudaki hassasiyet çok önemlidir. İlerleyen çalışmalarda klinik popülasyonlara yönelik kılavuzlar oluşturulmalı ve HIIT’in uzun süreli etkileri geniş kitlelerde araştırılmalıdır.
SPOR İŞLETMECİLİĞİNDE GÜNCEL SORUNLAR VE ÇÖZÜM ÖNERİLERİ
Authors: TURAK KAPLAN Berna , DOĞANER Seçkin , KAPLAN Mehmet
Published: September 2023

Spor işletmeleri günümüz spor endüstrisi içerisinde ciddi bir yere sahiptir. Bu sektör geliştikçe, ilgi ve katılım artmıştır. Bu gelişim zaman içerisinde farklı beklentileri ortaya çıkarmıştır. Bu nedenle üye katılımının sağlanması, rekabet unsurları gibi faktörler, işletmenin öne çıkmasına neden olmaktadır. Günümüzde yönetim unsurları, daha fazla üye çekebilmek adına bu tip işletmelerde ciddi efor sarfetmektedir. Araştırmada bu tip işletmelerin sorunları ve çözüm önerileri üzerine çalışılmıştır. Bu nedenle spor işletmesi yöneticilerine oluşturulan sorular üzerinden nitel bir çalışma yapılmıştır. Araştırmada amaçlı örnekleme yöntemi kullanılmıştır. Elde edilen veriler, nitel analiz programı ile analiz edilmiş ve ortaya çıkarılan kodlar, tema başlıkları ile birleştirilmiştir. Araştırma sonuçlarına göre üç ana tema oluşturulmuş ve bu başlıklar altında kodlamalar ve kullanıcı görüşleri incelenmiştir. Araştırma sonuçlarına göre, spor hizmeti alan kişiler çoğunlukla deneyimli ve bilgili eğitmenlerin olduğu spor işletmelerine katılım göstermek istediklerini belirtmişlerdir. Bu durum yöneticilerin uzman kişilerle çalışmasına, farklı branşlar geliştirmesine ve tesis şartlarının iyileştirilmesi üzerine çalışmalarına neden olmaktadır. Aynı zamanda sosyal ve ekonomik şartların, kültürel olgulara göre şekillenmesine çaba gösterdikleri görülmüştür. Yöneticilerin, üye beklentileri ve sağlık hizmetleri konusunda zorlandıkları görülmüş olup, bu sorunları aşmak için ciddi çaba gösterdikleri tespit edilmiştir. Beklentilerin karşılanması için rekabet ve reklam unsurları öne alınarak farklı iyileştirmeler yapılmaya çalışıldığı belirtilmiştir. Araştırma sonuçları literatür ile karşılaştırılmıştır ve elde edilen sonuçlar incelenerek, uygun çözüm önerileri makalede sunulmuştur.
Nilai Rapor dan Pengaruhnya terhadap Capaian Akademik Mahasiswa Pendidikan Matematika Universitas Malikussaleh
Authors: Zahara Yulia , Mujtahid Zainul , Elisyah Nur , Ningtiyas Fitri Ayu , Sinaga Nurul Afni
Published: September 2023

Kemampuan kognitif yang memadai menjadi modal penting bagi mahasiswa dalam menempuh studi lanjut. Kemampuan kognitif awal mahasiswa dapat dilihat dari nilai rapor selama menjadi siswa di sekolah menengah atas. Peneliti ingin mengetahui bagaimana pengaruh antara kemampuan kognitif mahasiswa dengan capaian akademik yang diperoleh selama menempuh studi di perguruan tinggi. Penelitian ini merupakan penelitian kuantitatif. Populasi penelitian merupakan mahasiswa semester III program studi pendidikan matematika Universitas Malikussaleh dengan sampel acak sebanyak 31 orang. Data dikumpulkan menggunakan google form yang diisi oleh setiap mahasiswa yang menjadi sampel penelitian. Data dianalisa menggunakan uji regresi linier sederhana. Setelah dilakukan uji statistik, diketahui bahwa tidak terdapat pengaruh antara nilai rapor mahasiswa selama bersekolah dengan capaian akademik di jenjang perkuliahan. Semakin tinggi nilai rapor sekolah tidak menandakan semakin baik capaian akademik mahasiswa tersebut. Semakin rendah nilai rapor sekolah tidak menandakan semakin rendah capaian akademik mahasiswa tersebut.