bluuebunny/crossref_metadata_2025 huggingface dataset:
ESTUDO QSAR CLÁSSICO DE UMA SÉRIE DE
ANÁLOGOS DE PIRIMIDINILSALICILATOS (PSA)
COM POTENCIAL ATIVIDADE BIOLÓGICA HERBICIDA
Authors: Faria Adriana Cássia de , Motta Luiz Frederico
Published: March 2023

Os herbicidas correspondem à classe dos agrotóxicos ou defensivos agrícolas utilizados para controlar e matar plantas daninhas. Os análogos de PSA correspondem à categoria de herbicidas inibidores da enzima acetolactato sintase (ALS), que interferem na biossíntese dos aminoácidos ramificados (leucina, isoleucina e valina), interrompendo o mecanismo de síntese proteica nas células vegetais. O presente trabalho tem como objetivo realizar o estudo QSAR clássico com intuito de obter um modelo multiparamétrico para predizer as respectivas atividades biológicas experimentais e que por intermédio dos descritores moleculares selecionados através da Análise Quimiométrica, proporcionar uma melhor compreensão das interações intermoleculares entre o ligante (herbicida) e o receptor biológico (enzima: ALS). Observou-se que todos os compostos não violaram a regra de Lipinski e que os descritores moleculares: número de Sítios Aceptores de Ligações de Hidrogênio (SALH), Log do coeficiente de partição (Log P), Área Superficial Polar (ASP), contribuição da forma iônica (aniônica = desprotonada), como também a ocorrência de efeitos eletrônicos do tipo mesomérico e indutivo podem estar correlacionados com a atividade biológica experimental. Importante ressaltar a possibilidade de interação eletrostática, interações intermoleculares do tipo ligações de hidrogênio e dipolo induzido do ligante com os resíduos de aminoácidos no sulco ativo da enzima ALS. O estudo também revelou a importância dos descritores moleculares: Log KOW (hidrofóbico/hidrofílico), HBN (termodinâmico), Gap (eletrônico) e Volume Molecular (estereoquímico). O modelo linear multidimensional proposto apresenta bom grau de ajuste linear, significância estatística e grau de previsibilidade considerável com relação à atividade biológica dos dados experimentais.
ANÁLISE FARMACOCINÉTICA E TOXICOLÓGICA IN SILICO PARA DERIVADOS DE FLAVONAS
Authors: Motta Luiz Frederico , Correa Gabriel Veloso , Cezário Stephanie Priscila de Sousa
Published: March 2023

Os análogos de flavonas são compostos naturais da classe dos flavonoides que apresentam ampla gama de atividades biológicas. O presente estudo objetivou predizer com auxílio de metodologias in silico a biodisponibilidade oral e análises farmacocinéticas e toxicológicas para três análogos de flavonas (apigenina, crisina e luteolina). O estudo revelou que os análogos apresentam boa disponibilidade oral, parâmetros farmacocinéticos e toxicológicos favoráveis. O Screening Virtual realizado para predição da biodisponibilidade oral revelou que todos os análogos não violaram a Regra de Lipinski. O estudo farmacocinético in silico revelou que todos os análogos possuem elevada absorção intestinal, não atravessam a barreira hematoencefálica, são permeáveis pelas células Caco-2 e não inibem a glicoproteína P. O estudo ADME in silico mostrou que todos os análogos inibem as enzimas do complexo citocromo P450 (CYP4501A2, CYP4502C9, CYP4502C19, CYP4503A4) e que apenas a enzima CYP4502D6 não sofre inibição. O estudo Toxicológico in silico indicou que os análogos não apresentam toxicidade pelo Teste de AMES e não são carcinogênicos. A apigenina e a crisina apresentam baixa toxicidade, enquanto a luteolina possui toxicidade moderada.
AVALIAÇÃO DA ATUAL SITUAÇÃO DO ATERRO CONTROLADO DE TERESINA, PIAUÍ - BRASIL
Authors: Ramos Mariana Fontenele , Silva Marina Luz Da , Monteiro Cristiane Barbosa
Published: March 2023

Objetivo: Através deste artigo buscou-se analisar como ocorre a disposição final dos resíduos sólidos urbanos produzidos em Teresina em seu aterro controlado. Métodos: Foi examinado se esse tipo de aterro é viável e adequado para que o município possa dar uma destinação final aos seus resíduos, de modo que os impactos negativos causados à população e ao meio ambiente sejam mínimos, analisando, também, como se deu a sua operação até os dias atuais e quando tal aterro atingirá a sua vida útil de operação. Resultados: As informações apresentadas mostraram que o aterro controlado resolveu parcialmente a problemática da deposição de resíduos sólidos na cidade, possibilitando que o lixo seja depositado em uma região própria, pois oferece menos riscos ao meio ambiente que os lixões. Conclusão: O aterro controlado de Teresina corresponde com a sua função no recebimento dos resíduos sólidos do município, porém necessita de alterações específicas para tornar-se mais apto a oferecer riscos considerados mínimos à população do meio ambiente e da cidade.
DEPRESSÃO E EXERCÍCIO FÍSICO
Authors: SANTOS A. A. , NASCIMENTO F. W. Á
Published: March 2023

A depressão é definida como um distúrbio que provoca alterações de ordem social, psicológica, fisiológica e biológica. Pessoas diagnosticadas como depressivas apresentam impactos no funcionamento psicossocial, saúde física, mortalidade e qualidade de vida. Na busca por um tratamento não farmacológico, o exercício físico tem se mostrado relevante no tratamento dessa doença. Trata-se de uma revisão de literatura onde foi utilizando as bases de dados da PubMed, Scielo, Periódico da Capes, Google Acadêmico e livros publicados no período até o ano de 2022. O objetivo deste estudo é investigar os benefícios do exercício físico para as pessoas que tem depressão e aborda as possibilidades que a Educação Física proporciona para evitar essa doença, pois os exercícios favorecem o desenvolvimento não somente do corpo, mas também da saúde mental das pessoas. Conclui-se através das pesquisas abordadas neste estudo que o exercício físico contribui no tratamento e na prevenção da depressão, fatores como liberação de hormônios e, principalmente, a socialização com outras pessoas são os pontos mais positivos para o sucesso do tratamento e prevenção dessa doença que afeta e tira a vida de milhões de pessoas ao redor do mundo.
USO DAS TECNOLOGIAS DIGITAIS COMO ESTRATÉGIA PARA O ENSINO REMOTO DA DISCIPLINA DE CIÊNCIAS NA ESCOLA APULCRO MOTA/SE DURANTE A PANDEMIA DE COVID-19
Authors: Neves R. J. , Rivemales M. C.C. , Praxedes M.F.S.
Published: March 2023

O isolamento social ocasionado pela pandemia do COVID-19 levou a uma corrida dos sistemas de ensino na busca de estratégias para garantia da continuidade do ensino mesmo que distante do espaço escolar. Devido a isso, este trabalho pautou-se em um relato de experiência que envolveu o uso da Tecnologia Digital de Informação e Comunicação (TDIC) na disciplina de Ciências com os alunos da escola Municipal Apulcro Mota, na tentativa de contornar as diferentes limitações já presentes no setor educacional público, potencializadas pela pandemia. Como TDIC, foi utilizado principlamente o software Stellarium Astronomy devido a sua gratuidade, facíl acesso e apresentar situações reais. De modo complementar os alunos foram incentivados a construção de um simulador de fases da Lua, visando trabalhar os contéudos da disciplina de Ciências de forma atrativa para reduzir a evasão e falta de motivação dos alunos e atingir os objetivos propostos da disciplina. Notou-se que quando a TDIC’s utilizada pelo docente consegue motivar os alunos, estes ficam atentos as aulas e se interessam mais quando o conteúdo é trabalhado de tal forma que possibilite a contextualização com as suas vivências para além do espaço escolar.
VULNERABILIDADE SOCIAL, INIQUIDADES EM SAÚDE E MORBIMORTALIDADE MATERNA EM MULHERES NEGRAS
Authors: Carvalho Ycaro de Sousa , Barbosa Valéria Raquel Alcantara
Published: March 2023

A magnitude da vulnerabilidade social no Brasil se associa a um cenário complexo e controverso atravessado por injustiças e desigualdades evitáveis de gênero, raça/cor e socioeconômicas, assim como a múltiplos condicionantes culturais e psicossociais atrelados às iniquidades em saúde, que repercutem negativamente na situação de saúde de mulheres no período gravídico-puerperal, impactando na morbimortalidade materna. Nesse sentido, o presente capítulo focaliza os principais fatores de vulnerabilidade que contribuem para a morbimortalidade de mulheres negras no Brasil. Para isso, realizou-se levantamento bibliográfico, a partir da apreciação de artigos, publicações técnicas e normativos legais nacionais sobre o tema. Evidenciou-se as idiossincrasias, multidimensionalidades e interseccionalidades que trespassam os contextos de vulnerabilidade social, iniquidades em saúde e morbimortalidade materna em mulheres negras no país. Defende-se a importância do fomento e do fortalecimento de espaços de debates acerca da saúde da mulher negra no ciclo gravídico-puerperal, em vista do impulsionamento da transformação de práticas profissionais, educacionais e de políticas públicas de cunho eminentemente emancipatórias, de tal maneira que dignifiquem a promoção do cuidado em saúde com sentido, de fato e em ato, equânime, universal, igualitário e antirracista.
HIERARQUIZAÇÃO DE FATORES QUE INFLUENCIAM NO ATRASO DAS VIAGENS DE TRANSPORTE COLETIVO DA REGIÃO METROPOLITANA DE GOIÂNIA (RMG): O CASO DA COOPERATIVA COOTEGO
Authors: Beirigo Filho I. , Sousa J. , Paiva M.
Published: March 2023

Esse artigo teve como objetivo identificar e hierarquizar os fatores que influenciam no atraso nas viagens de transporte coletivo da Região Metropolitana de Goiânia (RMG), especialmente da Cooperativa COOTEGO. Assim, o questionamento a ser respondido neste trabalho é: Quais são os fatores mais representativos nos atrasos das viagens por ônibus na Cooperativa COOTEGO. O método utilizado para responder tal questionamento envolve: (i) Caracterização da Área de Estudo e da Empresa Prestadora de Serviço; (ii) Levantamento de dados sobre atraso de viagens junto a órgãos públicos e empresa prestadora do serviço; (iii) Coleta de Dados (caso necessário) utilizando o instrumento de Pesquisa apresentado neste trabalho; (iv) tabulação dos dados; (v) Hierarquização dos Fatores interveniente no atraso de viagens. Para testar a aplicabilidade desse método, aplicou-se nas viagens realizadas pela COOTEGO no ano de 2017. Desta aplicação, foi possível observar que cerca de 97% dos atrasos das viagens do transporte coletivo da concessionária estudada são referentes à conduta do motorista desta Cooperativa, seguido pelas condições em que o trânsito opera. Esses resultados servem de subsídio para tomadores de decisão na definição de estratégias que visem melhorar a qualidade do serviço prestado, a partir de intervenções que busquem com que os motoristas respeitem o tempo de início de cada viagem.
TECNOLOGIA E ENSINO DO PORTUGUÊS NA CULTURA DIGITAL
Authors: Lima T. S. S.
Published: March 2023

Esta pesquisa tem como objetivos analisar as TICs como uma ferramenta potencial de ensino, além de entender a tecnologia como uma aliada no processo de aprendizagem de alunos de língua materna. O referencial teórico-metodológico está pautado, sobretudo, nos postulados de Dussel (2010), que aponta para as mudanças nas relações de ensino-aprendizagem mediadas pela tecnologia em contextos digitais, e toma por base a técnica da entrevista semiestruturada, que busca proporcionar perguntas a partir de um eixo temático específico (CERETTO & GIACOBBE, 2013). A análise dos resultados evidenciou que, professores entrevistados sabem como ensinar neste contexto, porém a falta de infraestrutura escolar e capacitação docente é (muitas vezes) o maior obstáculo.
The Comparison of P, PI and PID Strategy Performance as Temperature Controller in Active Iris Damper for Centralized Air Conditioning System
Authors: Nur’Amirah Busu  , Norasikin Mat Isa  , Azian Hariri  , Mohamed Hussein
Published: March 2023

The topic of maintaining thermal comfort efficiency in the heating, ventilation and air conditioning (HVAC) sector has always been tricky due to numerous challenges. The study focused on the challenge of under-actuated zones in non – residential and commercial buildings. The active iris damper with the integration of thermal controller is proposed to control the indoor temperature. Besides, integration of PID control strategy will be a tempting control system in enhancing the thermal performance of the building. Again, the PID controller has proven good compatibility as a primary closed-loop mechanism to maintain a comfortable room temperature. The development of the control system is done through the Arduino platform with LabVIEW as the front panel and data logging platform. The Heuristic tuning method was employed to obtain optimal gains for P, PI and PID controllers. The performance of each controller was tested by observing their ability to maintain steadily at the desired temperature set point. These tests conveyed that the best controller for this application is the PID controller. It reached the desired temperature set point and maintained it even with a temperature disruption. This study indicates that an active iris damper can effectively maintain the thermal comfort performance of indoor environment with the implementation of PID strategy, thus remedying some of the problems faced by centralized air-conditioning systems.
Effect of Heat Pipe’s Configuration in Managing the Temperature of EV Battery
Authors: Faiza Mohamed Nasir  , Mohd Zulkifly Abdullah  , Mohd Azmi Ismail
Published: March 2023

Because of their high energy density and long cycle life, lithium-ion batteries are commonly employed in electric cars. As battery performance and life are highly dependent on temperature, it is critical to maintain the optimum temperature range. A battery thermal management system (BTMS) is critical for controlling the thermal behaviour of the battery. Air cooling, liquid cooling, direct refrigerant cooling, phase change material (PCM) cooling, and heat pipe cooling are all BTMS strategies. Heat pipes come in a variety of sizes and configurations that can be employed in the BTMS and many studies have proven the feasibility of using heat pipe as the electric vehicles’ BTMS. However, there are many aspects of the design and configuration of the heat pipe that could affect the overall thermal performance of the heat pipe BTMS such as its length, diameter, evaporator and condenser lengths, tilt angle, types of heat pipes and working fluids. In this work, a numerical study was conducted to investigate the effect of heat pipe’s diameter, number of heat pipes and the types of heat pipes on the thermal performance of the heat pipe BTMS. The diameter of the heat pipe varies between 6 – 12 mm, the number of heat pipes varies from 2 – 10 and the type of heat pipe considered in this work is straight heat pipe. The thermal performance of the heat pipe is measured by the maximum battery temperature and the thermal resistance at different battery heat generation rate in the range of 10 - 30W. The simulation model was validated against experimental data and results indicate excellent agreement between simulation and experimental data. Simulation results shows that the greater the diameter, the lower is the battery temperature. By increasing the heat pipe’s diameter, the battery temperature can be reduced by at least 10% or 3.4°C. Temperature reduction of at least 12.7% was observed when the number of heat pipes used in the BTMS increases.
Numerical Investigation of Heat Transfer Enhancement in Circular Channel with Variation in Angle of Delta-Winglet Vortex Generator
Authors: M Iqbal Farhan Putra Arya  , Syaiful  , Muchammad  , Maria F. Soetanto
Published: March 2023

Vortex generators have been used to enhance heat transfer in numerous industries. Vortex generators improve flow mixing by destroying the thermal boundary layer, which improves heat transfer. This study aimed to improve heat transfer in circular channels by installing delta-winglet vortex generators. Accordingly, delta-winglet vortex generators with different angles – 90°, 105°, 120°, 135°, and 150° – were installed in an in-line arrangement. The k–ω turbulent SST model was applied to Reynolds numbers ranging from 4,000 to 12,000, varied at an interval of 2,000. The results indicated that a delta-winglet vortex generator with an angle of 90° increased heat transfer by 4.05% compared to that with an angle of 150°, while the flow resistance also increased by 7.18%. The delta-winglet vortex generator with an angle of 90° achieved the highest thermal enhancement factor of 2.55, whereas that with an angle of 150° provided the lowest cost–benefit ratio of 0.61.
Enhancement of Double-Pipe Heat Exchanger Effectiveness by Using Porous Media and TiO2 Water
Authors: Firas F. Qader  , Adnan M. Hussein  , Suad H. Danook  , Barhm Mohamad  , Omar S. Khaleel
Published: March 2023

In this paper, the rate of heat transfer by forced convection in a counterflow heat exchanger, at turbulent flow conditions were investigated experimentally, using porous media and TiO2 Nanofluid to observe the behaviour of heat transfer with flow rate and volume concentration of nanoparticles t enhance heat transfer through it. 3 mm Steel balls (ε=39.12%) as a porous media completely filled to the inner pipe (core pipe). The cold and hot water are used as working fluids through the inner and outer pipes. Then using, the TiO2 nanofluid instead of cold water flowing through the porous pipe to enhance heat characteristics. The effects of operating parameters include flow rate (4 LPM, 6 LPM, and 8 LPM), Reynolds number between (3000 – 7000), and nanoparticle volume fraction (0.001, 0.002 and 0.003) on Convective heat transfer co-efficient and Nusselt number. Effective thermal conductivity is increased when the nanoparticle volume fraction is increased. The heat transfer coefficient increases with decreasing nanofluid temperature, but the heating fluid's temperature has no significant effect on the nanofluid's heat transfer coefficient. The results show that porous media and TiO2-based nanofluid's improve heat transfer at flow rate of 4 LPM by 35.4% and improve NTU and effectiveness at flow rate of 4LPM by 12.4%, and 24%, respectively, when compared to pure water without porous media. This improvement in thermophysical properties yielded high heat transfer of heat exchangers used in process industries.
Penggambaran Penyakit Mental pada Portal Berita Daring selama Pandemi Covid-19: Perbandingan pada Tempo.co dan Kompas.com
Authors: Izzati Raihan Sabili , Wibowo Kunto Adi , Fuady Ikhsan
Published: March 2023

Portal berita daring menjadi salah satu media digital yang banyak diakses oleh masyarakat untuk mendapatkan berbagai informasi. Terdapat dua portal berita daring yang cukup dikenal oleh masyarakat Indonesia, yaitu Tempo.co dan Kompas.com. Sejak tahun 2019 lalu, kedua portal berita tersebut tidak henti memberikan informasi mengenai pandemi Covid-19, terutama mengenai penyakit mental akibat pandemi ini. Dengan menggunakan teori framing, penelitian ini bertujuan untuk mengetahui bagaimana perbedaan penggambaran penyakit mental pada portal berita daring Tempo.co dan Kompas.com. Penelitian ini menggunakan metode analisis isi kuantitatif untuk menganalisis teks pada portal berita daring. Pengambilan sampel dilakukan dengan menggunakan teknik probability simple random sampling dalam kurun waktu masa PSBB di Jakarta, yaitu dari 10 April hingga 4 Juni 2020. Didapatkan sampel sebanyak 65 artikel berita untuk Tempo.co dan 100 artikel berita untuk Kompas.com yang diambil berdasarkan enam kata kunci, yaitu “penyakit mental”, “penyakit jiwa”, “gangguan mental”, “gangguan jiwa”, “kesehatan mental”, dan “kesehatan jiwa”. Data dianalisis menggunakan perhitungan statistik nonparametrik chi square contingency coefficient. Hasil penelitian menunjukkan bahwa terdapat perbedaan penggambaran karakteristik berbahaya bagi diri sendiri pada Tempo.co dan Kompas.com, tetapi tidak terdapat perbedaan penggambaran penyebab, solusi, serta tone of article pada Tempo.co dan Kompas.com.
Prospects for Ray-tracing Light Intensity and Polarization in Models of Accreting Compact Objects Using a GPU
Authors: Moscibrodzka Monika A. , Yfantis Aristomenis I.
Published: March 2023

The Event Horizon Telescope (EHT) has recently released high-resolution images of accretion flows onto two supermassive black holes. Our physical understanding of these images depends on the accuracy and precision of numerical models of plasma and radiation around compact objects. The goal of this work is to speed up radiative-transfer simulations used to create mock images of black holes for comparison with the EHT observations. A ray-tracing code for general relativistic and fully polarized radiative transfer through plasma in strong gravity is ported onto a graphics processing unit (GPU). We describe our GPU implementation and carry out speedup tests using models of optically thin advection-dominated accretion flow onto a black hole realized semianalytically and in 3D general relativistic magnetohydrodynamic simulations, low and very high image pixel resolutions, and two different sets of CPU+GPUs. We show that a GPU with high double precision computing capability can significantly reduce the image production computational time, with a speedup factor of up to approximately 1200. The significant speedup facilitates, e.g., dynamic model fitting to the EHT data, including polarimetric data. The method extension may enable studies of emission from plasma with nonthermal particle distribution functions for which accurate approximate synchrotron emissivities are not available. The significant speedup reduces the carbon footprint of the generation of the EHT image libraries by at least an order of magnitude.
Hackathons and other participatory open science formats
Authors: Fahrenkrog Gabriele , Heller Lambert , Blümel Ina
Published: March 2023

This paper aims to provide a structured overview of four open, participatory formats that are particularly applicable in inquiry-based teaching and learning contexts: hackathons, book sprints, barcamps, and learning circles. Using examples, mostly from the work and experience context of the Open Science Lab at TIB Hannover, we address concrete processes, working methods, possible outcomes and challenges.

The compilation offers an introduction to the topic and is intended to provide tools for testing in practice.
Radical Politics, Left Convergence And The War of Position
Authors: Worth Owen
Published: March 2023

One of the central problems in leftist thought in the twenty-first century has been the ability to unite its various parts in order to develop some form of wider convergence capable of challenging the post-cold war neoliberal capitalist order. Despite numerous rich critiques of the
workings of neoliberal capitalism, political strategy has all too often been recued to a renewal of a dated twentieth-century statist project on the one hand and an ambiguous process of civil contestation on the other. This article builds on recent calls for convergence on the left, particularly
between the grand traditions of Marxism and Anarchism, which have seen an unparalleled renaissance in innovative development in the last thirty years. It suggests that an open-ended framework of Gramsci's 'war of position' provides an avenue for this convergence to build forms of political
strategy. Whilst Gramscian hegemony has often been understood as one of the problematic concepts within leftist though and indeed one that has often led to divergence, it suggests that inclusive version of the term as applied by Stuart Hall and Raymond Williams remains one in which convergence
can develop and thrive.
Tolkien, la Création et la technique
Authors: Gautier Benoît
Published: March 2023

J. R. R. Tolkien était un écrivain et professeur de philologie, surtout connu pour deux romans Le Hobbit et Le Seigneur des anneaux qui font partie d’un univers de fiction foisonnant dont il a créé, durant la majeure partie de sa vie, la géographie, les peuples, l’histoire et les langues. Dans son œuvre, la figure du technicien et la réflexion sur la technique tiennent une place importante. Il n’est pas anodin que celui qui a profondément influencé le monde contemporain de la fantasy, et qui fut lui-même un fervent catholique, s’inspire d’une théologie de la Création où l’homme est pensé comme cocréateur.
Russian and Eastern Europe collections at the International Institute of Social History (IISH)
Authors: Internationaal Instituut voor Socia
Published: March 2023

Cet article présente l’historique et le contenu des fonds relatifs à la Russie et l’Europe de l’Est conservés à l’ Internationaal Instituut voor Sociale Geschiedenis /Institut d’histoire sociale (IISG/IISH) d’Amsterdam. Il traite en particulier des archives des dissidents et des émigrés politiques russes et de l’Europe de l’Est socialiste, notamment de la Pologne et de l’ex-Tchécosovaquie.
Efficacy of spinal manipulations and Schroth exercises on psychological parameters in patients with functional scoliosis: a randomised controlled trial
Authors: Gera C. , Malik M.
Published: March 2023

Functional scoliosis is defined as the reversible and temporary lateral spinal curvature that mainly occurs due to abnormal postural habits that leads to non-structural and compensatory changes in spine. Functional scoliosis can lead to the development of mental health issues, such as stress, anxiety and depression. The purpose of the present study was to evaluate the effects of spinal manipulation techniques and Schroth exercises on psychological parameters in patients with functional scoliosis. The subjects were randomly allocated into experimental (n=31) and control group (n=31). Spinal manipulation techniques and Schroth exercises were given to the patients of experimental group, while only Schroth exercises were given to the patients of control group. Outcome measures were Depression, Anxiety & Stress Score that was examined by using ‘DASS-21 questionnaire’. Treatment was given for four weeks, thrice weekly. After the completion of four weeks, DASS scores were obtained from the participants. Patients were followed up after 2 months and data was collected again. Repeated measures ANOVA were used to compare the mean changes within-group. Independent t-test was used to analyse the mean improvement between-group. Results suggested that there was a statistically significant difference between pre-/post and pre-/follow-up scores of the DASS, but there was statistical non-significant difference between post-/follow-up scores of the DASS. Results also suggested that experimental group showed better improvement compared to the control group. This study concluded that the combine use of spinal manipulation techniques and Schroth exercise protocol can significantly reduce the psychosomatic symptoms in functional scoliosis.

Clinical Trial Registry of India: CTRI/2020/02/023221
A comparison of the associations between bone turnover markers and different sports fields: combat versus team sports
Authors: Yıldız K. , Uzunçakmak S. Karabulut , Halıcı Z. , Özçelik C. , Yazıcı A.G.
Published: March 2023

Sedentary life brings risks that include osteoporosis, while physical activity has many benefits for health in general and the skeletal system. Irisin is a hormone-like myokine regulated by mechanical force and it contributes to cortical and trabecular bone mineral density. This study aimed to investigate the effects of different types of sports on bone health by measuring elite athletes’ fibronectin type III domain 5 (FNDC5), N-terminal collagen type I extension propeptide (PINP), and C-terminal cross-linking telopeptide of type I collagen (CTXI) levels. Combat sports athletes, team sports athletes, and sedentary control subjects were enrolled. Serum levels of proteins were measured by ELISA. FNDC5 levels of elite athletes were higher compared to the sedentary controls (P=0.0014). The highest FNDC5 level was measured in wrestlers among all considered groups. The PINP levels of the athletes were also higher than those of the sedentary control group (P=0.1431). The highest PINP level was determined in boxers. The CTXI levels of the athletes were lower than those of the sedentary control (P<0.0001). The lowest CTXI level was seen in boxers. The FNDC5 and PINP levels of combat sports athletes were higher than those of team sports athletes (P=0.0134 and P=0.0262, respectively), while the CTXI levels of combat sports athletes were lower than those of team sports athletes (P<0.0001). Our results indicated that FNDC5, PINP, and CTXI levels are associated with physical activity. The effect of the exercises performed by athletes of specific sports on bone health has not been studied in much detail before. Combining different exercises for athletes of a particular sport may be more beneficial for bone health.
Asymptotic estimated digestibility, a new indicator of black soldier fly (Hermetia illucens) conversion efficiency in relation to larval density
Authors: Guillaume J.B. , Mezdour S. , Marion-Poll F. , Terrol C. , Schmidely P.
Published: March 2023

Black soldier fly larvae (BSFL) are highly efficient at converting organic substrates into insect biomass suitable for livestock nutrition. BSFL conversion efficiency depends on the nature of their feed, and formulation approaches use macronutrient contents to reach a targeted performance. However, digestibility varies between ingredients and BSFL digestibility data is lacking due to methods unsuitable for insects living in their feed. This study proposes to work under a range of larval densities to reach total ingestion of the feed, and defines Estimated Digestibility (ED) as the difference between distributed feed and frass macronutrient weight, divided by macronutrient weight in distributed feed. Using the same amount of chicken feed, same feeding time and 0 to 29 larvae/cm2, ED of dry mass (DM), starch, nitrogen, ether extract (EE), neutral detergent fibre, acid detergent fibre, acid detergent lignin, ash and energy were evaluated, along with survival rate, feed conversion ratio (FCR) and larval individual mass gain on a fresh and dry basis. ED of DM, starch, nitrogen, EE and energy increased with larval density following an asymptotic trend. ED of ash increased between 0 and 11.4 larvae/cm2 but decreased for higher densities. Using a logistic model, asymptotic ED of DM (80.3±1.3%), starch (99.0±2.3%), nitrogen (78.6±1.1%), EE (95.3±1.5%), ash (58.4±1.0%) and energy (80.6±1.2%) were determined. No effect of areal density on ED of fibre fractions was detected. Survival rate and individual mass gain peaked at densities below 5 larvae/cm2, FCR (dry to fresh) was improved with increasing density, while FCR (dry to dry) was optimised at 11.4 larvae/cm2. Asymptotic ED is a new indicator corresponding to the maximal fraction of macronutrients potentially digestible by BSFL. It should be used to develop a diet formulation approach based on digestible rather than crude macronutrient contents. Further studies should focus on evaluating asymptotic ED in different ingredients.
Machine learning-based evaluation of application value of pulse wave parameter model in the diagnosis of hypertensive disorder in pregnancy
Authors: Zhang Xinyu , Meng Yu , Jiang Mei , Yang Lin , Zhang Kuixing , Lian Cuiting , Li Ziwei
Published: March 2023

Hypertensive disorder in pregnancy (HDP) remains a major health burden, and it is associated with systemic cardiovascular adaptation. The pulse wave is an important basis for evaluating the status of the human cardiovascular system. This research aims to evaluate the application value of pulse waves in the diagnosis of hypertensive disorder in pregnancy.This research a retrospective study of pregnant women who attended prenatal care and labored at Beijing Haidian District Maternal and Child Health Hospital. We extracted maternal hemodynamic factors and measured the pulse wave of the pregnant women. We developed an HDP predictive model by using support vector machine algorithms at five-gestational-week stages.At five-gestational-week stages, the area under the receiver operating characteristic curve (AUC) of the predictive model with pulse wave parameters was higher than that of the predictive model with hemodynamic factors. The AUC values of the predictive model with pulse wave parameters were 0.77 (95% CI 0.64 to 0.9), 0.83 (95% CI 0.77 to 0.9), 0.85 (95% CI 0.81 to 0.9), 0.93 (95% CI 0.9 to 0.96) and 0.88 (95% CI 0.8 to 0.95) at five-gestational-week stages, respectively. Compared to the predictive models with hemodynamic factors, the predictive model with pulse wave parameters had better prediction effects on HDP.Pulse waves had good predictive effects for HDP and provided appropriate guidance and a basis for non-invasive detection of HDP.
CoT-UNet++: A medical image segmentation method based on contextual transformer and dense connection
Authors: Yin Yijun , Xu Wenzheng , Chen Lei , Wu Hao
Published: March 2023

Accurate depiction of individual teeth from CBCT images is a critical step in the diagnosis of oral diseases, and the traditional methods are very tedious and laborious, so automatic segmentation of individual teeth in CBCT images is important to assist physicians in diagnosis and treatment. TransUNet has achieved success in medical image segmentation tasks, which combines the advantages of Transformer and CNN. However, the skip connection taken by TransUNet leads to unnecessary restrictive fusion and also ignores the rich context between adjacent keys. To solve these problems, this paper proposes a context-transformed TransUNet++ (CoT-UNet++) architecture, which consists of a hybrid encoder, a dense connection, and a decoder. To be specific, a hybrid encoder is first used to obtain the contextual information between adjacent keys by CoTNet and the global context encoded by Transformer. Then the decoder upsamples the encoded features by cascading upsamplers to recover the original resolution. Finally, the multi-scale fusion between the encoded and decoded features at different levels is performed by dense concatenation to obtain more accurate location information. In addition, we employ a weighted loss function consisting of focal, dice, and cross-entropy to reduce the training error and achieve pixel-level optimization. Experimental results demonstrate that the proposed CoT-UNet++ method outperforms the baseline models and can obtain better performance in tooth segmentation.
Problems and solutions to conduct of thesis of postgraduate medical students during the COVID-19 pandemic: an insight into the students perspective
Authors: Sahoo Alok Kumar , Mishra Nitasha , Jain Mantu , Sahoo Manisha , Ghoshal Premangshu
Published: March 2023

Purpose: The coronavirus disease 2019 (COVID-19) pandemic has adversely impacted medical education worldwide. However, its impact on the postgraduate medical thesis and dissertation work is still not evaluated. Through this study, we planned to find out the problems brought by the pandemic and likely alternatives and possible solutions to thrust the academic competence of postgraduate students.Methods: After obtaining institutional ethics committee approval, we sent a 13-item questionnaire to postgraduate medical students in India via various social media online platforms. Data on the impact of the COVID-19 pandemic on thesis work and alternatives/solutions to improve the research competence were collected on a Likert scale and analyzed.Results: We received a total of 398 responses out of which 377 entries were included for final analysis. The majority of participants (88%) reportedly had an adverse impact on the thesis work and out of 25% of the participants who recently submitted their around 45% had to do so without achieving the estimated sample size. The 6-month departmental review for thesis progress was seen in merely 28% of participants. Possible alternatives suggested were the maintenance of log books, task-based assessment of research methodology, departmental audits, and systematic reviews. Solutions suggested for improving the research competence of students were a compulsory research methodology curriculum, a biostatistics department in each institution, permission to conduct thesis work beyond submission time, exclusive time for research work, and financial incentives.Conclusion: Modification in the research aspect of the current postgraduate medical education is the need of the hour and the pandemic has enlightened us regarding the current weaknesses.
L’alimentation en eau de deux villages du Gard rhodanien au XIXe siecle : Laudun-l’Ardoise et Saint-Victor-la-Coste
Authors: Pecout Philippe
Published: March 2023

Durant la deuxième moitié du XIXe siècle, les bourgs de Laudun-l’Ardoise et de Saint-Victor-la-Coste, situés dans la région de Bagnols-sur-Cèze dans le Gard, lancent à quelques années d’intervalle des projets d’adduction d’eau pour leurs habitants. Leurs problématiques reflètent bien celles des autres villages du midi de la France à cette période. Au-delà de la nécessité d’alimenter les populations et les animaux en eau de source, les municipalités concernées engagent des moyens importants afin de donner à leurs réalisations une dimension architecturale non négligeable. Dans une volonté de restructurer l’urbanisme et de donner un accès à l’eau potable, élus, architectes et entrepreneurs témoignent de leur ingéniosité et de leur profond attachement au nouveau régime républicain en édifiant des monuments originaux et fonctionnels.
L’histoire du Canal du Midi à travers les médailles
Authors: Eisler William , Le Brazidec Marie-Laure
Published: March 2023

L’eau est au centre d’un ouvrage remarquable qui, à la fin du XVIIe siècle, va permettre de faire la jonction entre les deux mers, océan atlantique et Méditerranée, à partir de Toulouse : le Canal du Midi, construit par Pierre-Paul Riquet. Les débuts des chantiers de construction sont marqués par des émissions de médailles, locales pour la fondation du port de Sète et celle de la première écluse à Toulouse, mais également officielles sous l’autorité de la Petite Académie, venant prendre place dans les séries métalliques de l’histoire du règne de Louis XIV. Ces médailles, qui vont ainsi véhiculer les images du Canal et ses ports jusqu’au-delà des frontières, sont ici présentées, avec celles qui les suivront aux XVIIIe et XIXe siècles.
Le principe de solidarité écologique : une avancée pour le droit de la biodiversité ?
Authors: Jolivet Simon
Published: March 2023

Le principe de solidarité écologique devrait permettre la pensée de nouveaux liens : spatiaux, temporels et entre êtres vivants. Cet article interroge ses apports à son domaine historique d’apparition, le droit de la biodiversité. En droit des aires protégées, et plus largement dans la dimension territoriale du droit de la biodiversité, la solidarité écologique apparaît assez bien établie conceptuellement, même si sa concrétisation reste largement perfectible. Au départ limitée par la loi au droit des parcs nationaux, la logique de solidarité écologique a été implicitement étendue au droit des réserves naturelles par le juge administratif. De plus, les continuités écologiques de la trame verte et bleue devraient permettre de prolonger la solidarité écologique sur le reste du territoire national, en dehors des aires protégées, et d’y ajouter une dynamique d’ordre temporel. En revanche, le droit de la protection des espèces apparaît paradoxalement en retrait dans l’institution de la logique de solidarité écologique. En témoignent notamment les politiques de « régulation » de la faune sauvage, qui négligent souvent les interdépendances entre les êtres vivants tout en transcendant les statuts juridiques (espèces « nuisibles », espèces protégées, etc.). Des pistes sont suggérées pour y remédier, telles que la mise en synergie du principe de solidarité écologique avec d’autres principes du droit de l’environnement, en particulier celui de précaution.
Microstructural Characterization of Polylactide/Poly ɛ-Caprolactone Blends for Plate Fixation Internal Application
Authors: Solechan  , Suprihanto Agus , Widyanto Susilo Adi , Triyono Joko
Published: March 2023

The recovery of a fractured femur using the plate and screw internal fixation. The plate internal fixation is made of metal has good mechanical strength, but causes allergic reactions, secondary surgery, stress shielding and high costs. Evaluation of the lack of metal, now developed biodegradable polymers use Polylactide (PLA) and Poly ɛ-caprolactone (PCL). The advantages of PLA and PCL materi-als can control the rate of degradation and increase mechanical strength. Manufac-turing processes of the plate fixation internal using cold isotactic pressing. Inde-pendent variable on the PLA/PCL blends from 90/10, 80/20, 70/30, and 60/40 wt% and tested for FTIR, XRD, SEM, density and porosity. Result from adding PCL make the degree of crystallinity is decreased significantly. The formation of semi-crystalline the with peak width smaller and the crystal size bigger in the 60PLA sample. PLA/PCL blends largely formed bonding and some immiscibility in the form of small flakes and cavities after the addition of PCL content. Large cavities reduce density and increase porosity which can affect mechanical proper-ties. 90PLA sample has high density and low porosity of 1,186 g/cm3 and 4% porosity, respectively.
New Research of Borehole Wall Protection Technology in Ocean Scientific Drilling
Authors: Li Xingchen , Xie Wenwei , Liu An , Yu Yanjiang , Xiong Liang , Yu Peizhi , Xiong Zhengqiang , Feng Xuelei , Cui Shuying , Zeng Jing
Published: March 2023

Abstract In the process of ocean scientific drilling, borehole accidents (e.g., borehole collapse, burying of drill tools, and sticking of drill tools) are often caused by borehole wall instability in loose and broken strata. It is very difficult to deal with such accidents,
and the drill pipe in the borehole has to be discarded in serious cases. Therefore, the stability of the borehole wall seriously affects the drilling quality and efficiency. At present, there are three effective methods of ensuring wellbore stability: casing, drilling fluid, and agent plugging
technology. Casing can effectively prevent instability of all types of unstable formations and can isolate different pressure zones. Using the proper drilling fluid can control drilling fluid loss, reduce free water infiltration into the borehole wall, and form a thin and dense mud skin, which
is conducive to the stability of the borehole wall. Agent plugging technology, especially chemical gels, is mainly aimed at the broken zone. After entering the formation, it makes the entire broken zone form a single high strength unit, improves the cementation ability of the lost formation,
and improves the sealing and bearing capacity in order to achieve the purpose of sealing and plugging of leaks. In this paper, the present situation, technical principles, and technological processes of wall protection technology in ocean scientific drilling are summarized, and the different
types of wall protection technology were researched and tested. The results of this study provide a reference for international ocean scientific drilling in the future.
Lactate Level and Clearance as Predictors of Neurologic Outcome After Cardiopulmonary Resuscitation
Authors: Brux Hannah , vom Dahl Juergen , Haake Hendrik
Published: March 2023

Background

Cardiac arrest with subsequent cardiopulmonary resuscitation is common in emergency medicine and is often associated with an unfavorable neurologic outcome. Lactate level corresponds to the severity of tissue hypoxia and damage and thus could be useful in predicting neurologic outcome.

Objectives

To investigate whether lactate and its clearance can serve as early prognostic biomarkers of neurologic outcome after cardiopulmonary resuscitation.

Methods

This study was a retrospective analysis of 249 patients of the Kliniken Maria Hilf hospital who survived at least 12 hours after cardiac arrest and cardiopulmonary resuscitation between 2012 and 2020. Multivariable logistic regressions were performed to correlate the neurologic outcome with lactate level, lactate clearance, and treatment-related patient data to identify factors that are predictors of neurologic outcome.

Results

A lactate level greater than 4.2 mmol/L at admission was significantly associated with an unfavorable neurologic outcome. Among patients with a lactate level greater than 4.2 mmol/L at admission, lactate clearance at 24 hours after admission that was greater than 80.9% was associated with a significant decrease in the probability of an unfavorable neurologic outcome.

Conclusions

These results suggest that lactate and its clearance have an impact on neurologic outcome and can be used as prognostic biomarkers and in treatment decision-making in patients with cardiac arrest and successful resuscitation.
Acute kidney injury in Coronavirus disease-19 related pneumonia in the intensive care unit: a retrospective multicenter study, Saudi Arabia
Authors: Eldaboosy Safwat A.M. , Awad Amgad , Farouk Abdullah , Mahdy Waheed , Abdelsalam Eman , Nour Sameh O. , Kabil Ahmad , Taha Ahmad , Makled Sameh , Lotfy Ahmed , Nabway Usama , Kanany Hatem
Published: March 2023

Background: Acute kidney injury (AKI) poses a significant morbidity and mortality risk to critically ill COVID-19 patients. The aim of this study was to investigate the incidence, predictors, and outcomes of AKI in patients admitted to the intensive care unit with critically ill COVID-19 pneumonia.Methods: A multicenter retrospective study in Saudi Arabia of adult patients aged at least 18 years diagnosed with COVID-19 pneumonia and admitted to the intensive care unit between May 2020 and May 2021. The occurrence of acute kidney injury and associated risk factors, the need for continuous renal replacement therapy, and the outcome were reported.Results: The study included 340 patients admitted to the ICU with COVID-19. Their mean age was 66.7±13.4 years, ranging from 49 to 84 years, and most of them were men (63.8%). The most common concomitant diseases were hypertension (71.5%), diabetes (62.4%), IHD (37.6%), CKD (20%), heart failure (19.4%), and 81.2% suffered from ARDS. AKI occurred in 60.3% of patients, 38% were stage 1, 16.6% were stage 2, and 45.4% were stage 3. Approximately 39% of patients required continuous renal replacement therapy (CRRT), of which 76.2% were stage 3, which was significantly higher than the other stages (p<0.001). AKI patients suffered significantly from asthma and had lower levels of C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), and blood urea nitrogen (BUN) and higher creatinine levels than patients without AKI (p<0.05 all). The overall mortality rate was 39.4%, and the mortality rate was significantly higher in patients with AKI than in patients without AKI (48.3% versus 25.9%; p<0.001).Conclusion: AKI is common in adults admitted to the intensive care unit with COVID-19 and is associated with an increased risk of death. Early detection of AKI and appropriate treatment can positively impact COVID-19 the outcome. CRRT is the preferred dialysis method in critically ill ICU patients with AKI.