bluuebunny/crossref_metadata_2025 huggingface dataset:
Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
Authors: Smetanina Olga F. , Yurchenko Anton N. , Girich (Ivanets) Elena V. , Trinh Phan Thi Hoai , Antonov Alexander S. , Dyshlovoy Sergey A. , von Amsberg Gunhild , Kim Natalya Y. , Chingizova Ekaterina A. , Pislyagin Evgeny A. , Menchinskaya Ekaterina S. , Yurchenko Ekaterina A. , Van Tran Thi Thanh , Afiyatullov Shamil S.
Published: December 2019

Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.
Inhibitory Effect of Osthole from Cnidium monnieri on Tobacco Mosaic Virus (TMV) Infection in Nicotiana glutinosa
Authors: Chen Ya-Han , Guo Dong-Sheng , Lu Mei-Huan , Yue Jian-Ying , Liu Yan , Shang Chun-Ming , An De-Rong , Zhao Ming-Min
Published: December 2019

The coumarin compound of osthole was extracted from Cnidium monnieri and identified by LC-MS and 1H- and 13C-NMR. Osthole was tested for anti-virus activity against tobacco mosaic virus (TMV) using the half-leaf method. The results showed that stronger antiviral activity on TMV infection appeared in Nicotiana glutinosa than that of eugenol and ningnanmycin, with inhibitory, protective, and curative effects of 72.57%, 70.26%, and 61.97%, respectively. Through observation of the TMV particles, we found that osthole could directly affect the viral particles. Correspondingly, the level of coat protein detected by Western blot was significantly reduced when the concentrations of osthole increased in tested plants compared to that of the control. These results suggest that osthole has anti-TMV activity and may be used as a biological reagent to control the plant virus in the half-leaf method.
Sequential Diffusion Spectra as a Tool for Studying Time-Dependent Translational Molecular Dynamics: A Cement Hydration Study
Authors: Serša Igor
Published: December 2019

The translational molecular dynamics in porous materials are affected by the presence of the porous structure that presents an obstacle for diffusing molecules in longer time scales, but not as much in shorter time scales. The characteristic time scales have equivalent frequency ranges of molecular dynamics, where longer time scales correspond to lower frequencies while the shorter time scales correspond to higher frequencies of molecular dynamics. In this study, a novel method for direct measurement of diffusion at a given frequency of translational molecular dynamics is exploited to measure the diffusion spectra, i.e., distribution of diffusion in a wide range of frequencies. This method utilizes NMR modulated gradient spin-echo (MGSE) pulse sequence to measure the signal attenuation during the train of spin-echoes formed in the presence of a constant gradient. From attenuation, the diffusion coefficient at the frequency equal to the inverse double inter-echo time is calculated. The method was employed to study the white cement hydration process by the sequential acquisition of the diffusion spectra. The measured spectra were also analyzed by the diffusion spectra model to obtain the time-dependence of the best-fit model parameters. The presented method can also be applied to study other similar systems with the time evolution of porous structure.
Analysis of Polyphenolic Composition of a Herbal Medicinal Product—Peppermint Tincture
Authors: Bodalska Agnieszka , Kowalczyk Adam , Włodarczyk Maciej , Fecka Izabela
Published: December 2019

The pharmacological activity of peppermint leaf (Menthae piperitae folium) for medical use is mainly attributed to the presence of essential oil, which, according to the European Pharmacopoeia (Ph. Eur.), should constitute not less than 12 mL/kg of raw material. The content of polyphenols in peppermint-based preparations, except peppermint leaf dry extract, has not yet been considered as an essential parameter in the pharmacopeial assessment of peppermint quality. This study concerns the evaluation of the presence of representatives of polyphenolic compounds in 23 commercial peppermint tinctures (ethanolic extracts) purchased in pharmacies in Poland. The non-volatile polyphenolic fraction was investigated, and the presence of flavonoids and phenolic acids was quantified. High performance liquid chromatography coupled with a diode-array detector (HPLC-DAD) and an electrospray ionization mass spectrometer (U(H)PLC-ESI-MS) were used in the experiment. The study showed that eriocitrin, luteolin-7-O-rutinoside, and rosmarinic acid were the main polyphenolic components of the peppermint tinctures, as previously reported for peppermint leaf. Despite this, the research shows the extremely diverse content of the mentioned compounds in analyzed commercial medicinal products. In light of these results, it seems that the pharmacopeial assessment for the peppermint leaf (Ph. Eur.) and peppermint tincture (Polish Pharmacopoeia (FP)) requires correction and supplementation.
Griseaketides A–D, New Aromatic Polyketides from the Pathogenic Fungus Magnaporthe grisea
Authors: Yang Yin-He , Yang Da-Song , Lei Hong-Mei , Li Cheng-Yun , Li Guo-Hong , Zhao Pei-Ji
Published: December 2019

Magnaporthe grisea is the causal agent of rice blast disease, which is the most serious disease of cultivated rice. Aromatic polyketides are its typical metabolites and are involved in the infection process. In the search for novel lead compounds, chemical investigation of the fungus M. grisea M639 has led to the isolation of four new aromatic polyketides (salicylaldehyde skeleton bearing an unsaturated side chain), griseaketides A–D (1–4), as well as 15 known compounds (5–19). The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses, including HR-MS, 2D NMR. Compound 12 showed prominent activity that killed 94.5% of C. elegans at 400 ppm and 66.9% at 200 ppm over 24 h. This is the first report describing the nematicidal activity of this type aromatic polyketide.
Bio-Based Thermo-Reversible Aliphatic Polycarbonate Network
Authors: Durand Pierre-Luc , Grau Etienne , Cramail Henri
Published: December 2019

Aliphatic polycarbonates represent an important class of materials with notable applications in the biomedical field. In this work, low Tg furan-functionalized bio-based aliphatic polycarbonates were cross-linked thanks to the Diels–Alder (DA) reaction with a bis-maleimide as the cross-linking agent. The thermo-reversible DA reaction allowed for the preparation of reversible cross-linked polycarbonate materials with tuneable properties as a function of the pendent furan content that was grafted on the polycarbonate backbone. The possibility to decrosslink the network around 70 °C could be an advantage for biomedical applications, despite the rather poor thermal stability of the furan-functionalized cross-linked polycarbonates.
Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Aβ Fibril Assembly
Authors: Thamban Chandrika Nishad , Fosso Marina Y. , Tsodikov Oleg V. , LeVine Harry , Garneau-Tsodikova Sylvie
Published: December 2019

The fact that the number of people with Alzheimer’s disease is increasing, combined with the limited availability of drugs for its treatment, emphasize the need for the development of novel effective therapeutics for treating this brain disorder. Herein, we focus on generating 12 chalcone-donepezil hybrids, with the goal of simultaneously targeting amyloid-β (Aβ) peptides as well as cholinesterases (i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)). We present the design, synthesis, and biochemical evaluation of these two series of novel 1,3-chalcone-donepezil (15a–15f) or 1,4-chalcone-donepezil (16a–16f) hybrids. We evaluate the relationship between their structures and their ability to inhibit AChE/BChE activity as well as their ability to bind Aβ peptides. We show that several of these novel chalcone-donepezil hybrids can successfully inhibit AChE/BChE as well as the assembly of N-biotinylated Aβ(1–42) oligomers. We also demonstrate that the Aβ binding site of these hybrids differs from that of Pittsburgh Compound B (PIB).
Studies on the Solubility of Terephthalic Acid in Ionic Liquids
Authors: Matuszek Karolina , Pankalla Ewa , Grymel Aleksander , Latos Piotr , Chrobok Anna
Published: December 2019

Low solubility of terephthalic acid in common solvents makes its industrial production very difficult and not environmentally benign. Ionic liquids are known for their extraordinary solvent properties, with capability to dissolve a wide variety of materials, from common solvents to cellulose, opening new possibilities to find more suitable solvents for terephthalic acid. This work presents studies on the solubility of terephthalic acid in ionic liquids, and demonstrates that terephthalic acid is soluble in ionic liquids, such as 1-ethyl-3-methylimidazolium diethylphosphate, 1-butyl-3-methylimidazolium acetate, and dialkylimidazolium chlorides up to four times higher than in DMSO. Additionally, the temperature effect and correlation of ionic liquid structure with solubility efficiency are discussed.
A Novel Gel-Forming Solution Based on PEG-DSPE/Solutol HS 15 Mixed Micelles and Gellan Gum for Ophthalmic Delivery of Curcumin
Authors: Sai Na , Dong Xiaoxv , Huang Pingqing , You Longtai , Yang Chunjing , Liu Yi , Wang Wenping , Wu Huimin , Yu Yingchao , Du Yuanyuan , Leng Xin , Yin Xingbin , Qu Changhai , Ni Jian
Published: December 2019

Curcumin (Cur) is a naturally hydrophobic polyphenol with potential pharmacological properties. However, the poor aqueous solubility and low bioavailability of curcumin limits its ocular administration. Thus, the aim of this study was to prepare a mixed micelle in situ gelling system of curcumin (Cur-MM-ISG) for ophthalmic drug delivery. The curcumin mixed micelles (Cur-MMs) were prepared via the solvent evaporation method, after which they were incorporated into gellan gum gels. Characterization tests showed that Cur-MMs were small in size and spherical in shape, with a low critical micelle concentration. Compared with free curcumin, Cur-MMs improved the solubility and stability of curcumin significantly. The ex vivo penetration study revealed that Cur-MMs could penetrate the rabbit cornea more efficiently than the free curcumin. After dispersing the micelles in the gellan gum solution at a ratio of 1:1 (v/v), a transparent Cur-MM-ISG with the characteristics of a pseudoplastic fluid was formed. No obvious irritations were observed in the rabbit eyes after ocular instillation of Cur-MM-ISG. Moreover, Cur-MM-ISG showed a longer retention time on the corneal surface when compared to Cur-MMs using the fluorescein sodium labeling method. These findings indicate that biocompatible Cur-MM-ISG has great potential in ophthalmic drug therapy.
Formation of Mo5Si3/Mo3Si–MgAl2O4 Composites via Self-Propagating High-Temperature Synthesis
Authors: Yeh Chun-Liang , Chen Yin-Chien
Published: December 2019

In situ formation of intermetallic/ceramic composites composed of molybdenum silicides (Mo5Si3 and Mo3Si) and magnesium aluminate spinel (MgAl2O4) was conducted by combustion synthesis with reducing stages in the mode of self-propagating high-temperature synthesis (SHS). The SHS process combined intermetallic combustion between Mo and Si with metallothermic reduction of MoO3 by Al in the presence of MgO. Experimental evidence showed that combustion velocity and temperature decreased with increasing molar content of Mo5Si3 and Mo3Si, and therefore, the flammability limit determined for the reaction at Mo5Si3 or Mo3Si/MgAl2O4 = 2.0. Based upon combustion wave kinetics, the activation energies, Ea = 68.8 and 63.8 kJ/mol, were deduced for the solid-state SHS reactions producing Mo5Si3– and Mo3Si–MgAl2O4 composites, respectively. Phase conversion was almost complete after combustion, with the exception of trivial unreacted Mo existing in both composites and a minor amount of Mo3Si in the Mo5Si3–MgAl2O4 composite. Both composites display a dense morphology formed by connecting MgAl2O4 crystals, within which micro-sized molybdenum silicide grains were embedded. For equimolar Mo5Si3– and Mo3Si–MgAl2O4 composites, the hardness and fracture toughness are 14.6 GPa and 6.28 MPa m1/2, and 13.9 GPa and 5.98 MPa m1/2, respectively.
Vitamin and Mineral Supplementation Practices in Preterm Infants: A Survey of Australian and New Zealand Neonatal Intensive and Special Care Units
Authors: Oliver Colleen , Watson Caitlin , Crowley Elesa , Gilroy Melissa , Page Denise , Weber Katrina , Messina Deanna , Cormack Barbara
Published: December 2019

Preterm infants are at increased risk of micronutrient deficiencies as a result of low body stores, maternal deficiencies, and inadequate supplementations. The aim of this survey was to investigate current vitamin and mineral supplementation practices and compare these with published recommendations and available evidence on dosages and long-term outcomes of supplementations in preterm infants. In 2018, a two-part electronic survey was emailed to 50 Australasian Neonatal Dietitians Network (ANDiN) member and nonmember dietitians working in neonatal units in Australia and New Zealand. For inpatients, all units prescribed between 400 and 500 IU/day vitamin D, compared to a recommended intake range of 400–1000 IU/day. Two units prescribed 900–1000 IU/day at discharge. For iron, 83% of respondents prescribed within the recommended intake range of 2–3 mg/kg/day for inpatients. Up to 10% of units prescribed 6 mg/kg/day for inpatients and at discharge. More than one-third of units reported routine supplementations of other micronutrients, including calcium, phosphate, vitamin E, and folic acid. There was significant variation between neonatal units in vitamin and mineral supplementation practices, which may contribute to certain micronutrient intakes above or below recommended ranges for gestational ages or birth weights. The variations in practice are in part due to differences in recommended vitamin and mineral intakes between expert groups and a lack of evidence supporting the recommendations for supplementations.
Human Microglia Respond to Malaria-Induced Extracellular Vesicles
Authors: Mbagwu Smart Ikechukwu , Lannes Nils , Walch Michael , Filgueira Luis , Mantel Pierre-Yves
Published: December 2019

Microglia are the chief immune cells of the brain and have been reported to be activated in severe malaria. Their activation may drive towards neuroinflammation in cerebral malaria. Malaria-infected red blood cell derived-extracellular vesicles (MiREVs) are produced during the blood stage of malaria infection. They mediate intercellular communication and immune regulation, among other functions. During cerebral malaria, the breakdown of the blood–brain barrier can promote the migration of substances such as MiREVs from the periphery into the brain, targeting cells such as microglia. Microglia and extracellular vesicle interactions in different pathological conditions have been reported to induce neuroinflammation. Unlike in astrocytes, microglia–extracellular vesicle interaction has not yet been described in malaria infection. Therefore, in this study, we aimed to investigate the uptake of MiREVs by human microglia cells and their cytokine response. Human blood monocyte-derived microglia (MoMi) were generated from buffy coats of anonymous healthy donors using Ficoll-Paque density gradient centrifugation. The MiREVs were isolated from the Plasmodium falciparum cultures. They were purified by ultracentrifugation and labeled with PKH67 green fluorescent dye. The internalization of MiREVs by MoMi was observed after 4 h of co-incubation on coverslips placed in a 24-well plate at 37 °C using confocal microscopy. Cytokine-gene expression was investigated using rt-qPCR, following the stimulation of the MoMi cells with supernatants from the parasite cultures at 2, 4, and 24 h, respectively. MiREVs were internalized by the microglia and accumulated in the perinuclear region. MiREVs-treated cells increased gene expression of the inflammatory cytokine TNFα and reduced gene expression of the immune suppressive IL-10. Overall, the results indicate that MiREVs may act on microglia, which would contribute to enhanced inflammation in cerebral malaria.
Rapid High-Yield Transient Expression of Swine Hepatitis E ORF2 Capsid Proteins in Nicotiana benthamiana Plants and Production of Chimeric Hepatitis E Virus-Like Particles Bearing the M2e Influenza Epitope
Authors: Zahmanova Gergana G. , Mazalovska Milena , Takova Katerina H. , Toneva Valentina T. , Minkov Ivan N. , Mardanova Eugenia S. , Ravin Nikolai V. , Lomonossoff George P.
Published: December 2019

The Hepatitis E virus (HEV) is a causative agent of acute hepatitis, mainly transmitted by the fecal-oral route or zoonotic. Open reading frame (ORF) 2 encodes the viral capsid protein, which is essential for virion assembly, host interaction, and inducing neutralizing antibodies. In this study, we investigated whether full-length and N- and C-terminally modified versions of the capsid protein transiently expressed in N. benthamiana plants could assemble into highly-immunogenic, virus-like particles (VLPs). We also assessed whether such VLPs can act as a carrier of foreign immunogenic epitopes, such as the highly-conserved M2e peptide from the Influenza virus. Plant codon-optimized HEV ORF2 capsid genes were constructed in which the nucleotides coding the N-terminal, the C-terminal, or both parts of the protein were deleted. The M2e peptide was inserted into the P2 loop after the residue Gly556 of HEV ORF2 protein by gene fusion, and three different chimeric constructs were designed. Plants expressed all versions of the HEV capsid protein up to 10% of total soluble protein (TSP), including the chimeras, but only the capsid protein consisting of aa residues 110 to 610 (HEV 110–610) and chimeric M2 HEV 110–610 spontaneously assembled in higher order structures. The chimeric VLPs assembled into particles with 22–36 nm in diameter and specifically reacted with the anti-M2e antibody.
Development of Systems for the Production of Plant-Derived Biopharmaceuticals
Authors: Moon Ki-Beom , Park Ji-Sun , Park Youn-Il , Song In-Ja , Lee Hyo-Jun , Cho Hye Sun , Jeon Jae-Heung , Kim Hyun-Soon
Published: December 2019

Over the last several decades, plants have been developed as a platform for the production of useful recombinant proteins due to a number of advantages, including rapid production and scalability, the ability to produce unique glycoforms, and the intrinsic safety of food crops. The expression methods used to produce target proteins are divided into stable and transient systems depending on applications that use whole plants or minimally processed forms. In the early stages of research, stable expression systems were mostly used; however, in recent years, transient expression systems have been preferred. The production of the plant itself, which produces recombinant proteins, is currently divided into two major approaches, open-field cultivation and closed-indoor systems. The latter encompasses such regimes as greenhouses, vertical farming units, cell bioreactors, and hydroponic systems. Various aspects of each system will be discussed in this review, which focuses mainly on practical examples and commercially feasible approaches.
Radiometric Model and Inter-Comparison Results of the SGLI-VNR On-Board Calibration
Authors: Urabe Tomoyuki , Xiong Xiaoxiong , Hashiguchi Taichiro , Ando Shigemasa , Okamura Yoshihiko , Tanaka Kazuhiro
Published: December 2019

The Second Generation Global Imager (SGLI) on Global Change Observation Mission–Climate (GCOM-C) satellite empowers surface and atmospheric measurements related to the carbon cycle and radiation budget, with two radiometers of Visible and Near Infrared Radiometer (SGLI-VNR) and Infrared Scanning Radiometer (SGLI-IRS) that perform a wide-band (380 nm–12 µm) optical observation not only with as wide as a 1150–1400 km field of view (FOV), but also with as high as 0.25–0.5 km resolution. Additionally, polarization and along-track slant view observations are quite characteristic of SGLI. It is important to calibrate radiometers to provide the sensor data records for more than 28 standard products and 23 research products including clouds, aerosols, ocean color, vegetation, snow and ice, and other applications. In this paper, the radiometric model and the first results of on-board calibrations on the SGLI-VNR, which include weekly solar and light-emitting diode (LED) calibration and monthly lunar calibration, will be described. Each calibration data was obtained with corrections, where beta angle correction and avoidance of reflection from multilayer insulation (MLI) were applied for solar calibration; LED temperature correction was performed for LED calibration; and the GIRO (GSICS (Global Space-based Inter-Calibration System) Implementation of the ROLO (RObotic Lunar Observatory) model) model was used for lunar calibration. Results show that the inter-comparison of the relative degradation amount between these three calibrations agreed to within 1% or less.
Energy Management Practices’ Determinants in Greek Enterprises
Authors: Tachmitzaki Elpida V. , Didaskalou Eleni A. , Georgakellos Dimitrios A.
Published: December 2019

The implementation of energy management over recent decades has been considered to be particularly important for companies wishing to save energy resources, to tackle the issue of climate change, and, at the same time, maintain their competitive edge in an ever-changing environment. The main objective of this article is to identify and analyse all of those critical factors that may affect the implementation of effective energy management practices by Greek enterprises. A questionnaire survey was conducted to investigate the implementation of energy management in Greek enterprises. The survey was conducted between May and September 2016. Out of the 649 questionnaires sent, 132 were collected (a response rate of 20.3%). The implementation of energy management in Greek enterprises is affected particularly positively by the implementation of a structured and integrated energy management system as far as the main findings of the survey are concerned. The use of modern technology, the involvement of the employees, and the commitment of the senior management proved to be additional critical determinants in the implementation of energy management in the operation of businesses.
Population dynamics and life history of the rare arctic-alpine plant Sagina nivalis (Caryophyllaceae) on the Ben Lawers range, Scotland, UK
Authors: Mardon David K , Watts Sarah Helen
Published: December 2019

The flora of Scotland’s mountains is of international significance as it contains arctic-alpine species at the edge of their global range. Such rear edge populations deserve high priority investigation due to their unique local adaptations, important conservation value and because montane plants may be particularly sensitive to environmental change. Sagina nivalis is one of the rarest and least known arctic-alpines in Britain and the vast majority of plants occur within the Ben Lawers SSSI. Ten permanent plots were surveyed here from 1982-1994 by counting the number of plants and tagging and measuring individuals throughout the duration of their lives. The total number of plants present at each colony across the whole site was also recorded in 1996 and 2014. Extreme fluctuations in numbers occurred within periods of very few years and were associated with the fragile and dynamic nature of the montane habitat.  Seedling mortality was very high, but age had no effect on survival rates once plants were one year old. Most were small, only lived two years and produced none or few flowers, although those that survived long enough generally reached their maximum size and flowering potential when they were five years old. The number of plants present across the whole of Ben Lawers halved between 1996 and 2014, with half of all colonies extinct and a further third in significant decline. The greatest threats to S. nivalis in Scotland were identified as habitat damage due to natural processes, sheep activity and climate change. A reduction in snow cover may cause an interaction between these factors and compromise the long-term survival of rear edge populations of this species, other rare arctic-alpines in Scotland and their associated contribution to biodiversity.
Long-term monitoring of Green-winged Orchid (Anacamptis morio) at Upwood Meadows NNR, Huntingdonshire
Authors: Stroh Peter A.
Published: December 2019

The results of monitoring a population of Anacamptis morio over a 40-year period (1978-2017) in a permanent plot at Upwood Meadows NNR, Huntingdonshire, are presented. Flowering and vegetative plants were recorded each year, with individuals relocated using phenomarkers and triangulation. The majority of plants flowered for over half of their lifespan, the average lifespan of an individual plant was almost 10 years, and the known maximum lifespan above-ground for an individual was at least 36 years. The average age of the cohort became much younger over the course of the study, with potential reasons given including extreme old age, a lack of recruitment, and climate.
Deschampsia cespitosa subsp. parviflora (Poaceae) - an overlooked woodland grass
Authors: Amphlett Andy
Published: December 2019

Deschampsia cespitosa (L.) P. Beauv. subsp. parviflora (Thuill.) Dumort was, to British and Irish botanists, a little known taxon prior to1988, and current distribution mapping shows a marked geographical recording bias. It is confirmed as being primarily a woodland taxon, at low altitudes; modal mean altitude 50-75 m AOD, with 97% of locations at ≤300 m AOD. A combination of woodland or shaded habitat, bright green narrow leaves, and delicate panicle, with small spikelets, is suggestive of subsp. parviflora. In combination, degree of leaf blade scabridity on the adaxial surface, appearance of papillae on flat surfaces of adaxial ridges of the leaf, and spikelet length, provide the most reliable means of distinguishing this subspecies from subsp. cespitosa. There is no reason to suspect that subsp. parviflora is increasing, rather it had previously been overlooked.
Índios
Authors: Silva Edson
Published: December 2019

De uma forma geral, um dos maiores desafios para tratar a temática indígena no ensino é a superação de imagens românticas, exóticas e folclorizadas por visões críticas sobre os povos indígenas. As mobilizações sociopolíticas indígenas contemporâneas, a presença de índios estudando no Ensino Superior, bem como a Lei nº 11.645/2008, que determinou a inclusão da história e das culturas indígenas nos currículos da Educação Básica, exigem conhecimentos sobre os povos indígenas para novas reflexões e abordagens e para a produção de subsídios didáticos específicos, provocando questionamentos sobre a formação de professores e as práticas pedagógicas, possibilitando um pensamento crítico, evidenciando os protagonismos dos povos indígenas na História do Brasil e, por fim, permitindo discutir estereótipos, equívocos, preconceitos e (re)conhecer os significados que representam a sociodiversidade indígena em nosso país.
Um estudo sobre as contribuições das situações argumentativas para construção e estabilização dos conhecimentos na perspectiva da aprendizagem significativa crítica
Authors: Aquino Kátia Aparecida da Silva , Rayssa Suane de Araújo Lima  , Alice Sabrina Ferreira da Silva
Published: December 2019

O desafio de promovermos uma aprendizagem significativa crítica no ensino de ciências está relacionado à utilização de estratégias que contribuam para a negociação de significados e que sejam capazes de promover uma Aprendizagem Significativa. Com base nisso, buscamos avaliar como a utilização da argumentação pode potencializar a construção e estabilização do conhecimento para ser utilizado de forma crítica, mediante análises de mapas conceituais produzidos antes e após a vivência de situações argumentativas. O objetivo consiste em apontar possíveis contribuições decorrentes dessas intervenções para o processo de assimilação e retenção dos conhecimentos sobre a temática “conservantes alimentares”. Os resultados indicaram que novos significados foram incorporados aos conhecimentos prévios, contribuindo para estabilização destes conhecimentos após um provável período de obliteração, indicando possíveis evidências de uma aprendizagem significativa crítica em curso.
A influência das avaliações externas no trabalho docente e na significação de qualidade
Authors: Alves Alesandra Maia Lima , Betania de Andrade Martins Elita , Rangel Miranda Denise
Published: December 2019

O presente texto apresenta reflexões desenvolvidas como parte do estudo do grupo de pesquisa GESE (Grupo de Estudos em Sistemas de Ensino) coordenado por professores de uma escola federal e da Faculdade de Educação/UFJF. A pesquisa teve como objetivo identificar possíveis transformações nas práticas docentes e gestoras reconhecidas por profissionais da rede pública de Minas Gerais como decorrentes das atuais políticas educacionais. Utilizamos como suporte teórico-metodológico de Ball e Fairclough e utilizou como instrumentos de coleta dados questionários, entrevistas e análises de documentos. Parte das informações obtidas será aqui apresentada e revelaram que dentre as atuais políticas educacionais a avaliação externa tem assumido centralidade nas discussões realizadas nas escolas, provocando mudanças nas formas de trabalho sobretudo na ação docente que tem implicado em novas significações para o termo qualidade educacional.
Jogos teatrais e viewpoints
Authors: Silva Oliveira Mariana , Carvalho Luiza
Published: December 2019

O artigo aborda as propostas metodológicas dos Jogos Teatrais, de Viola Spolin, e dos Viewpoints, conforme Anne Bogart e Tina Landau, ambas em voga na área do teatro na educação brasileira. Pretende refletir sobre a hipótese de que, entre elas, é possível estabelecer convergências conceituais e de que praticá-las no mesmo grupo de trabalho pode oferecer resultados potentes e interessantes. Para tanto, apresentamos uma revisão conceitual dos principais livros que apresentam as metodologias, além de oferecer observações acerca de uma investigação prática com o uso de ambas no projeto de extensão “Escape – laboratório de experimentação cênica do CAp-UERJ”.
Yek-Âhenk ve Yek-Âvâz Gazel İçin Birer Terim Mi Yoksa Beğeni İfadesi Midir ?
Authors: YALÇINKAYA Şerife
Published: December 2019

Türk edebiyatının Tanzimat
edebiyatı dönemi sonrası yenileşme dönemi şahsiyetlerinden olan Muallim Nâcî (1849-1893),
şâir, yazar, sözlükçü ve edebiyat bilimcisi yönleriyle öne çıkmaktadır. Muallim
Nâcî, Batı etkisinde eserler veren Abdülhak Hamid (Tarhan) ve Recâizâde Mahmud
(Ekrem)’e karşı, eski edebiyatın savunucusu konumundadır. Muallim Nâcî edebî
eserler kadar teorik eserler de kaleme almıştır. Lugat-ı Nâcî ve Istılâhat-ı
Edebiyye ve isimli eserleri onun klâsik şiirimiz için de kullanılan önemli sözlükleridir.
Nâcî’nin her iki eseri de Tâhirülmevlevi tarafından gözden geçirilmiş ve eklemelerle
genişletilmiştir. Tâhirülmevlevi (1877-1951) geleneğe bağlı tavrı ile tanınan
bir Mevlevi dervişi, edebiyat bilimcisi, yazar ve şairdir.         Klasik Türk edebiyatı
geleneğinde şâirlerin şiirleri  ve şiir
anlayışları hakkında bilgi çıkarabileceğimiz en temel kaynak, tezkirelerdir.
Tezkirelerde şâir ve şiir değerlendirmelerinde bu kavramlar gözden geçirilmiştir.
Yine şâirler kendi şiirlerinde ve divan önsözlerinde de şiire dâir genel
değerlendirmelerde bulunurlar. Bu amaçla divan önsözleri ve divanlar gözden
geçirilmiş, klasik şerh kitaplarındaki durum tartışılmıştır.

Bu makalede, Muallim
Nâcî’nin Istılâhat-ı Edebiyye’sinde ve Tâhirülmevlevî’nin Edebiyat
Lugati’nde "yek-âheng gazel" ve "yek-âvâz gazel"
tanımlarına nasıl yer verdiği bu tanımların kendisinden sonra nasıl terimleştiğinden
söz edilecektir.
Analisis Swot Pemasaran Produk Kerupuk Buah di UD. Sukma Kecamatan Takisung Kabupaten Tanah Laut
Authors: Rizki Amalia Raden , Lestari Ema , Meldayanoor Meldayanoor
Published: December 2019

UD. Sukma merupakan industri pengolahan kerupuk buah. Permasalahan yang terjadi pada UD. Sukma yaitu dalam menjual produknya belum adanya identifikasi strategi bauran pemasaran yang dilihat dari faktor produk, lokasi, harga dan promosi untuk meningkatkan penjualan produk kerupuk buah yang menghasilkan kontinuitas terhadap penjualannya. Tujuan dari penelitian ini untuk menganalisis faktor yang paling mempengaruhi bauran pemasaran kerupuk buah secara internal dan eksternal serta menentukan strategi pemasaran kerupuk buah menggunakan metode SWOT. Metode penelitian yang digunakan yaitu identifikasi faktor-faktor marketing mix, wawancara, kuisioner, analisis faktor IFAS dan EFAS, dan analisis SWOT. Faktor internal yang paling mempengaruhi kekuatan (strength) yaitu merk yang digunakan sudah diketahui masyarakat sekitar dan sudah memiliki P-IRT, serta sudah mendapatkan label halal dari MUI.  Kelemahan dalam faktor internal yaitu kemasan yang digunakan kurang menarik, belum memiliki standar pengolahan produk yang menyebabkan ketidakkonsistenan kualitas produk kerupuk buah, dan tidak adanya promosi menggunakan media sosial. Sedangkan pada faktor eksternal peluang  yaitu pengiriman produk tepat waktu pada distributor, mempromosikan produk melalui instansi pemerintah. Adapun ancamannya yaitu  kemasan produk lain yang sejenis lebih menarik, terdapat pesaing dengan produk yang sama disatu tempat penjualan dan kerupuk UD. Sukma sudah dijual sampai luar daerah namun merk berbeda. Strategi yang tepat mengatasi pemasalahan UD. Sukma yaitu menggunakan strategi Strength-Oppurtunity (SO) yaitu dengan adanya label halal dan P-IRT merupakan kekuatan untuk memanfaatkan peluang yaitu dengan mempertahankan hubungan yang baik dengan distributor, memperluas area penjualan, serta adanya dukungan dari pemerintah baik melalui promosi berbentuk baliho, maupun mengikutkan pameran agar dikenal masyarakat luas.
Optimalisasi Limbah Tongkol Jagung pada Pembuatan Bioetanol dan Karakteristiknya dengan Perlakuan Periode Fermentasi dan Konsentrasi Ragi
Authors: Ruhibnur Refid , Aida Nur , Susanto Anto , Kurniawan Tardi , Rosmalinda Rosmalinda
Published: December 2019

Pemanfaatan tongkol jagung masih sangat terbatas. Kebanyakan limbah tongkol jagung hanya digunakan untuk bahan tambahan makanan ternak, atau hanya digunakan sebagai pengganti kayu bakar. Melihat komposisi selulosa dan hemi selulosa yang cukup besar, maka tongkol jagung sangat potensial untuk dimanfaatkan menjadi bioetanol. Bioetanol adalah etanol yang berasal dari makhluk hidup, dalam hal ini adalah bahan nabati. Bioetanol ini dibuat melalui proses fermentasi. Penelitian ini bertujuan untuk mendapatkan formulasi konsentrasi ragi dan lama periode fermentasi yang optimum agar dapat menghasilkan bioetanol limbah tongkol jagung sesuai standar mutu. Penelitian ini merupakan penelitian eksperimental faktorial dengan rancangan percobaan rancangan acak kelompok (RAK). Faktor yang dicoba dalam penelitian ini adalah: (1) perlakuan lama periode fermentasi (P), terdiri dari 3 taraf: P1 = 3 hari, P2 =  5 hari, dan  P3 = 7 hari. (2) perlakuan konsentrasi ragi (K), terdiri dari 3 taraf: K1 = 5%, K2 = 10%, dan K3 = 15%. Variabel yang diamati dalam penelitian ini, diantaranya: Uji kadar etanol (SNI7390:2008), Uji pH (SNI7390:2008), Kadar gula (Sudarmadji, 1997), Viskositas (Sudarmadji, 1997), dan Uji tampakan (pengamatan visual). Dari hasil penelitian yang terbaik untuk preparasi bahan maupun hasil bioetanol yang dihasilkan yaitu perlakuan P2K2 (penambahan konsentrasi ragi 10% dengan lama waktu fermentasi 5 hari) dengan nilai kadar gula pada bahan awal 3.98 (% brix), dan nilai pH 4.30 pada kondisi suhu 30oC, diperoleh nilai kadar etanol sebesar 34.57 (%v/v), pH sebesar 3.5, nilai viskositas sebesar 3,00 ppt, nilai kadar gula 0 % brix, dan memiliki warna secara visual jernih.
Analisis Penerapan Produksi Bersih Pengelolaan Sampah Di Tempat Pembuangan Akhir (TPA) Bakunci Kabupaten Tanah Laut
Authors: Meldayanoor Meldayanoor , Kiptiah Mariatul , Sari Dian Permata
Published: December 2019

Permasalahan sampah saat ini menjadi suatu hal yang memerlukan perhatian, karena sampah-sampah yang dibiarkan saja akan menimbulkan dampak negatif bagi lingkungan. Penelitian ini dilakukan di Tempat Pembuangan Akhir (TPA) Bakunci Kabupaten Tanah Laut. Tujuan dari penelitian ini yaitu untuk menganalisis pengolahan sampah di TPA Bakunci serta menganalisis penerapan produksi bersih dari segi kelayakan teknis, kelayakan lingkungan dan kelayakan ekonomi. Metode yang digunakan dalam penelitian ini yaitu wawancara, kuisioner, pengamatan langsung dan studi pustaka yang berkaitan dengan penelitian. Pengelolaan sampah di TPA Bakunci yaitu mengolah sampah organik diolah menjadi kompos, sampah organik diolah menjadi biogas dan sampah anorganik dikelola dibank sampah. Dilihat dari segi kelayakan teknis pengelolaan kompos dan bank sampah layak untuk dilanjutkan, sedangkan dari segi kelayakan lingkungan setiap pengelolaan sampah yang dilakukan tidak ada pengaruhnya terhadap lingkungan. Dilihat dari segi kelayakan ekonomi dalam pengelolaan kompos perkiraan keuntungan yang diperoleh yaitu Rp. 23.856.000/bulan dan pengelolaan bank sampah yaitu 28.818.900/bulan untuk 33 nasabah bank sampah.
Study and Performance Analysis of Different Techniques for Computing Data Cubes
Authors: Siddika Aiasha
Published: December 2019

Data is an integrated form of observable and recordable facts in operational or transactional systems in the data warehouse. Usually, data warehouse stores aggregated and historical data in multi-dimensional schemas. Data only have value to end-users when it is formulated and represented as information. And Information is a composed collection of facts for decision making. Cube computation is the most efficient way for answering this decision making queries and retrieve information from data. Online Analytical Process (OLAP) used in this purpose of the cube computation. There are two types of OLAP: Relational Online Analytical Processing (ROLAP) and Multidimensional Online Analytical Processing (MOLAP).This research worked on ROLAP and MOLAP and then compare both methods to find out the computation times by the data volume. Generally, a large data warehouse produces an extensive output, and it takes a larger space with a huge amount of empty data cells. To solve this problem, data compression is inevitable. Therefore, Compressed Row Storage (CRS) is applied to reduce empty cell overhead.
Refractory Grade Bauxite: An Overview about the Effects of different Bauxite Sources and Forming Processes on the Quality of the Material
Authors: de Oliveira Vitor Guilherme , Curimbaba Ferreira Luís Leonardo Horne , dos Reis Marcos Antônio , Nakachima Peter Miura , Pereira André Luis
Published: December 2019

Refractories have been very important for humankind development enabling the manufacturing of a wide range of materials. Primary industries demanding refractories include the manufacturing of steel, non-ferrous metals, glass, lime, cement, ceramics, petrochemicals and incineration. Refractory grade bauxites (RGBs) are high-alumina materials used as aggregates in shaped and unshaped refractory linings suitable to with stand high temperature heating and a corrosive environment. Despite the wide availability of bauxite ores in the world, few countries can supply a bauxite with refractory grades. Guyana, China and Brazil have emerged as suppliers for the refractory industry and the peculiarities of each bauxite from these countries impact directly on the refractory performance.
The Information System Of Name Card Sales Based On Digital Marketing To Improve Creativepreneur On College E-Commerce Website
Authors: Santoso Sugeng , Kauf Josch , Aristo Nabila Cynthia
Published: December 2019

Advances in technology and information have abundant benefits, especially in the business of business card services by utilizing e-commerce. When buying a business card, the buyer can order a business card by contacting the seller directly, then the order is processed to completion and finally reaches the buyer. However, this method is not in line with current technological advancements because it still uses conventional transaction processes. Therefore, to overcome this problem an e-commerce website is used that can process transactions accurately and quickly. In this study, there are 3 (three) problems that will be overcome with 2 (two) methods, and 3 (three) solutions are produced. The advantage of e-commerce website is that it can be accessed anytime and anywhere, so it is concluded that the use of e-commerce websites is able to overcome the problems found in business cards, business services and develop creativepreneur in Raharja Higher Education.
Urban Mexican Children and their Intermedia/Transmedia(lity) Cultural Habits
Authors: Nicolás-Gavilán Maria T. , Baptista-Lucio Maria Pilar
Published: December 2019

O artigo examina crianças do ensino fundamental e seus hábitos culturais intermídia / transmídia, da perspectiva dos alunos que cresceram em um ambiente multimídia em rápida mudança, definido aqui como o complexo ecossistema de textos e imagens que envolve as pessoas e que flui através da mídia tradicional e todos os formatos digitais. Como as crianças se relacionam com isso? A resposta a esta pergunta é guiada pela teoria clássica de usos e gratificações e pela abordagem Intermídia / Transmídia que nos ajuda a entender a nova ecologia do ambiente de mídia que cerca as crianças. Os dados foram coletados em escolas públicas e privadas da Cidade do México. Os resultados nos dão um instantâneo da interconectividade da mídia moderna e sua centralidade na vida das crianças.
Biopolitical Frames of Impoverished Women in Journalistic Photography about the Bolsa-Família Program
Authors: Marques Angela Salgueiro , Herrera Alexei Padilla
Published: December 2019

In this article we argue, with Foucault, Fassin and Butler, that there is a particular modality of government of collective bodies: the biopolitical framing of impoverished citizens and groups in the context of the implementation of social politics. The corpus of the research features a total of 120 images related to the Bolsa-Família Program, published between 2003 and 2015 in newspapers such as Folha de S. Paulo, Estado de S. Paulo and O Globo. The paper investigates the political and ethical dimensions of these images in order to show how the biopolitical and neoliberal government of collective bodies involves the production of narratives, arguments and discourses that trace distinctions between ways of life considered as dignified and those widely perceived as despicable. The biopolitical framing is a technique of government or governmentality that formats the scenes of appearance, preparing them to define exemplary citizens and groups, considered as a parameter, whose project and vulnerable way of life are seen as an antithesis of deviation and of existences morally judged as unworthy of consideration and appreciation.
A Comparative Analysis of Visitor Satisfaction in the Digital Museum
Authors: Dang Qiong , Segers Katia
Published: December 2019

A construção de um museu digital é complexa e é influenciada por inúmeras variáveis. Pesquisas anteriores sugeriram que a aplicação da tecnologia promove a preservação de relíquias culturais, o gerenciamento da digitalização, a disseminação eficaz do conhecimento tradicional e o pensamento crítico em museus. No entanto, o estudo sobre a relação entre sites de museu e visitantes parece estar faltando. Esta pesquisa visa preencher a lacuna baseada em dois casos: o Museu do Palácio e o Museu Henan. Os dados foram coletados de 17 entrevistados em profundidade e 557 questionários. Os resultados mostram que os fatores significativos que influenciam a satisfação do visitante nos sites dos museus são: qualidade da informação, qualidade do sistema, utilidade percebida, usabilidade percebida e imagem do museu.
Biomass to liquefied petroleum gas cooking energy: A solution to indoor pollution ailments in Temeke Municipality, Dar-Es-Salaam
Authors: Kamugısha Proscovia , Mahamudu Kombo Mohamed , Mhanga Sebastian
Published: December 2019

In 2010 World Health
Organization estimated that three people per minute die prematurely in
Sub-Saharan Africa from diseases attributable to Indoor Air Pollution (IAP).
About 95% of Tanzanians still use biomass cooking fuels (BCF) which is the main
source of IAP. Promotion of Liquefied Petroleum Gas (LPG) was done since
mid-2000s to substitute BCF. However, the use of LPG accounts for only 7.2% of
Tanzanians to date. Therefore this paper examined factors influencing use of
LPG in Temeke municipality - Dar-es-Salaam. Data were collected from 160
respondents using questionnaires and analysed by using Probit regression model.
Results revealed that  education level of
a household head, household income and time saved for cooking had significant
effect on use of LPG at a probability level of P<0.1. The probability of
using LPG increased by 3.4% with an increase of one more year of education for
household heads attaining formal education. Moreover, the probability of using
LPGs increased by 11% among household heads whose monthly income increased by
1million Tanzanian Shillings (USD 409). Surprisingly, the probability of using
LPG decreased by 0.2% as households saved an additional minute compared to
using biomass fuels.  It is recommended
that the government, private sector and development partners promote LPG use
through awareness creation; incorporating LPG use in education and energy
policy and conducting research on ‘value engineering of LPG cooking  facilities’ to reduce costs for users.
Investigation of Antibacterial Activity in Sea Fennel (Crithmum maritimum) Growing Wild in Giresun Coast
Authors: AKYURT İhsan , ERİKLİ Zehra
Published: December 2019

The proposed study introduces each of root, stalk, leaf, flowers and seed of Crithmum maritimum is extracted with five different organic solvents such as chlorophorm, hexane, acetone, ethanol and methanol. Antibacterial activities of these extracts were tested against four Gram (+) bacteria: Enterococcus faecalis ATCC29212, Staphylococcus epidermidis ATCC 12228, Bacillus cereus, Bacillus megaterium; five Gram (-) bacteria: Pseudomonas aeruginosa ATCC 27853, Proteus vulgaris, Salmonella typhimurium ATCC 14028, Escherichia coli K-12, Yersinia pseudotuberculosis. The in vitro antibacterial activity was performed by agar disc diffusion method.In conclusion, it was determined that Crithmum maritimum has got antibacterial activity.
Üniversite Öğrencilerinin Akvaryum Balıkları Satış Yerleri Hakkındaki Görüş ve Tutumları
Authors: AYDIN Baki
Published: December 2019

Ülkemizde akvaryum sektörü; üreticiler, ithalat
ve ihracat yapan firmalar, toptancılar, perakende akvaryumcu/petshop satış
yerleri ve tüketicilerden oluşmaktadır. Bu
araştırmada, üniversite öğrencilerinin akvaryum balıkları perakende satış yerleri
ile ilgili görüş ve tutumları tespit edilmesi amaçlanmıştır. Araştırmada çalışma
grubu, Akdeniz Bölgesi’ndeki bir devlet üniversitesinde öğrenim görmekte olan 600
öğrenciden oluşmaktadır. Araştırma, üniversite öğrencisi ile yüz yüze yapılan
görüşmelerle anket yoluyla gerçekleştirilmiştir. Üniversite öğrencilerinin
akvaryum balıkları satış yerleri ile ilgili görüş ve tutumlarının
belirlenmesine yönelik 19 kapalı uçlu sorudan oluşan 5’li likert-tipi tutum
ölçeği veri toplama aracı olarak kullanılmıştır. Anket yoluyla elde edilen verilerin
analizinde betimsel istatistikler, bağımsız örneklem t testi ve tek yönlü
varyans analizi kullanılmıştır. Anket çalışmasından elde edilen verilerin
istatistiksel analiz sonuçları yorumlanarak öğrencilerin akvaryum balıkları
satış yerleri hakkındaki görüş ve tutumları açıklanmaya çalışılmıştır. Ayrıca,
araştırma sonucunda satış yerleri ile ilgili olarak gelecekteki müşteri
profili, satış yerlerinin nasıl olması gerektiği ile ilgili fiziksel ortam ve
diğer konularda birtakım önerilerde bulunulmuştur.