bluuebunny/crossref_metadata_2025 huggingface dataset:
The difference between the cycloplegic and noncycloplegic refractive error may be an indicator for the myopia progression in myopic children
Authors: KOCAMIŞ Sücattin İlker , ÖZDEMİR İbrahim
Published: January 2022

Aim: We aimed to evaluate the relationship between the subjective and objective refractive error measurement difference and myopia progression in this study.

Material and Method: Children between 6-18 year-old at the beginning of the follow-up period having myopia and who were followed up regularly every six months and for a total of at least 36 months were included in the study. All children underwent a detailed ophthalmologic examination. An autorefractor (TOPCON KR1/RM1, Topcon, Oakland, New Jersey), was used to evaluate the refractive error. Those with a refractive error difference of less than 0.50 D (spherical equivalent) before and after cycloplegia were included in group 1. Those with a refractive error difference of higher than 0.50 D were included in group 2. Myopic progression of the groups was compared.

Results: This study comprised 44 patients (male, 23; female, 21) in group 1 and 42 patients (male, 22; female, 20) in group 2. The age range and mean age±SD of patients in group 1 were 6-17 years and 11.4±3.0 years, respectively, whereas that of patients in group 2 was 6-17 years and 12.6±3.3 years, respectively. Both groups were followed for similar periods (p= 0.141). It was 37.5±2.4 (range 36-48) months in group 1 and 36.8±1.6 (range 36-42) months in group 2. The range and mean of the cycloplegic refractive error at the beginning of the following period in group 1 were -2.37±1.15 D, and -1.75±0.99 D in group 2 respectively (p= 0.010). At the end of the following period, the mean cycloplegic refractive error were -2.73±1.11 D in group 1, and -3,33±0.91 D in group 2 respectively (p= 0.008). During follow-up, the change in cycloplegic refractive error was 0.36±0.16 D in group 1, and 1.57±0.46 D in group 2. It was significantly lower in group 1 than group 2 (p< 0.0001).

Conclusion: We demonstrated that myopic children having high baseline difference between the objective and subjective spheric equivalent measurements had more myopia progression.
How effective are body mass index and body muscle weight on cardiopulmonary resusitation?
Authors: BORA Ejder Saylav , ÇAKIR Adem , YAMANOĞLU Adnan
Published: January 2022

Aim: The purpose of this study is searching the effect of BMI and BMW on the quality of CPR and the state of exhaustion applied by the professionals in the emergency department.

Material and Method: The software of the CPR education manikin was used in order to count and measure the number and the depth of the compressions and their correspondence to each other during the first and the second minutes of the procedure. Five cycles of chest compressions were asked to do from the rescurers. Each rescuer has handed the task of applying pressure over to his/her following team member after two minutes. Borg tiredness scores were asked to the rescuers and recorded at the end of each-minute period.

Results: The mean depth of pressure, the number of pressure attempts applied and the number of superficial compressions of the participants who were grouped due to their BMI showed no statistically meaningful difference. Both in the mean values of Borg tiredness scores which were calculated at the end of the first and second minutes; the group with lower BMW showed higher exhaustion significantly and this group couldn’t make sufficient compressions by means of depth and number, and also the latter showed more exhaustion compared to the first.

Conclusion: It is considered that choosing the health workers who are going to apply CPR among individuals with higher BMW or encouraging the workers in those departmnets who frequently apply CPR to be more interested in sports activities could be a promoting factor for having good quality CPR and reducing mortality as well.
Review of COVID-19 vaccinated patients' emergency room admissions
Authors: DURMUŞ Ensar , GUNER Necip Gökhan , GÜNEYSU Fatih , ASLAN Nuray , YURUMEZ Yusuf
Published: January 2022

Introduction: This study was aimed to define the demographic structure of vaccinated patients admitted to the emergency room (ER) with COVID-19 symptoms, and their hospitalization status, length of stay (LoS) in hospital, and mortality status.

Material and Method: This research is a retrospective, cross-sectional and descriptive study. Furthermore, it includes the period between 15.01.2021 and 30.04.2021.

Results: An 887 COVID-19 vaccinated patients who applied to ER. Of these, 383 (42.2%) were male, and 504 (56.8%) were female. The mean age of the patients was 52±18.6 years. The number of single-dose vaccinated patients was 696 (78.5%), and the two-dose vaccinated was 191 (21.5%). CoronaVac (Sinovac Life Sciences) vaccine was applied to 755 (85.1%), and BNT162b2 (Pfizer & Biontech) vaccine was applied to 132 (14.9%) patients before.

In 317 (35.7%) cases, reverse transcription-polymerase chain reaction (Rt-PCR) positivity was detected in the ER application after vaccination. Of the total patients, 86 (9.7%) were hospitalized, 14 (1.4%) patients died in the hospital.

The mean time between vaccination and application to ER was 25 (±21.9) days. Also, this period was 28.1 (±18) days in two-dose vaccinated patients.

Conclusion: People who are vaccinated with the COVID-19 vaccine continue to have hospital admissions with COVID-19 symptoms. Rt-PCR positivity, need for hospitalization, and mortality may continue to be seen in vaccinated individuals.
The relationship of obstructive sleep apnea risk with the disease severity and clinical parameters in COPD population
Authors: KELEŞ Ali Onur , ŞAHİN DUYAR Sezgi , AKSU Funda , FIRAT Selma
Published: January 2022

Aim: Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) have common pathophysiological mechanisms affecting the prognosis of each other. This study aims to investigate the relationship between the presence of OSA risk and the severity of COPD and to determine the possible clinical features for OSA risk for COPD patients.

Material and Method: The patients (n=181) who applied to the outpatient clinics of pulmonology between September - November 2019 with the diagnosis of COPD, were analyzed cross-sectionally. Demographic features, anthropometric measurements, comorbidities, smoking status, and severity of dyspnea, respiratory functions, and exacerbation frequency in the last year were evaluated. All patients were questioned with the Epworth sleepiness scale (ESS) for detecting excessive daytime sleepiness (EDS), and the STOP-Bang for determining the risk of OSA.

Results: The rate of diabetes, waist and hip circumference measurements, median ESS score, and EDS ratio were found to be higher in patients with moderate/high OSA risk when compared to patients with low OSA risk. In the multivariate regression model; lower oxygen saturation (OR: 0.83; p=0.007) and higher ESS score (OR=1.28; p
Problems of Subject Raising Constructions among Yoruba ESL Learners
Authors: Raheem Razaq Akolawole
Published: January 2022

Raising is an upward movement that concerns structures whose derivation involves copy, merger, and deletion and movement operations in the Minimalist Program. The proficiency of Yorùbá ESL learners and speakers of English is hindered as a result of interference from the mother tongue and divergence in raising constructions. Thus, this study examines subject-raising constructions in English and Yorùbá to explicate the root cause of the problem and the extent to which Yorùbá learners of English could be affected. Chomsky’s copy-theory of movement is adopted as the theoretical framework. Data for both languages are drawn from syntax literature. The Yorùbá data are supported with introspection. Different types of subject raising such as subject-to-subject, object-to-subject raising and raising of the clause to the subject position are carefully studied.

This study discovers that subject raising in English is different from what is permitted in Yorùbá. A raised element in Yorùbá often leaves behind a presumptive pronoun for convergence. While raising is permitted in non-finite structure in English, Yorùbá allows raising in a finite clause. Therefore, raising structures especially subject raising, are not easy for Yorùbá learners of English due to language variations. Thus, learners are forced to avoid the structure or misapply their LI knowledge on similar construction in the English language. It is concluded that teachers of English should be aware of these areas of difficulties for effective teaching and learning processes.
Viewing the African Political Leadership Challenge through the Lens of Music Drama: Reflections on Duro Ladipo’s Ọba Kòso
Authors: Samuel Kayode
Published: January 2022

In response to the question of the relevance of ‘classical’ African Studies to the contemporary need of the continent, this article explores the dynamics of leadership challenge as portrayed in Yorùbá music drama genre, using Duro Ladipo’s most popular folk opera: Ọba Kòso (The king did not hang) as a case study. Thematic exploration of the opera was carried out to establish the linkages between leaders’ (characters’) traits and styles as portrayed in the play, and Nigeria’s political leaders’ engagement and responses to social contracts with their citizens. By comparing the outcomes of the actions, inactions and (in) decisions of Nigeria’s political leaders and the attendant consequences on their subjects with those found in the opera. I argue that the African political leadership challenge is shaped by a combination of complex factors, including the leaders’ charisma and the quality of citizens’ engagements in the affairs of governance. These are largely occasioned by multiple effects of torrential and irresistible mob pressures on leaders. At the fringes of the debacle is a convergence of human fate and other coincidental elements within the various sites of the divide in the contestation for and utilization of power as a whole.
Acting Styles, Nuances and Linguistic Aesthetics: A Case Study of Ibrahim Chatta in Yoruba Films
Authors: Fadirepo Adejoke Adetoun , Oresanya Adeyemi Oluwadamilare
Published: January 2022

Acting style is the artistic feature and ingenuity of the actor exhibited over a long period of time acting in films. It is the attainment and acquisition of skills, ingenious and professional creativity, exhibited by the actor in the process of carrying out a role in film or play production. Acting style can be inferred to be individualistic. In Yoruba films, there is a crop of non-native actors who are fluent in the language of their nativity as well as being conversational in the Yoruba language movies which aid their celebrity status. The inability to acculturate to the expected character through diction, gesticulation and socio-linguistic nuances create disorientation between the actors and the audience. This study is hinged on Whorpian Theory on language which posits that the individual perceives his or her environment through the process of thought which is influenced by the language he uses. The method of research is content analytical. Film content is analyzed to raise awareness on the style, nuances linguistic aesthetics of Ibrahim Chattah in selected films. Our findings show that producers and casting directors are the culprit of this deficiency, due to their sense of profit making by using casts with celebrity status in order to increase their profit margin at the show room. This study thereby concludes that directors, producers and casting directors should be more creative by developing a sense of professionalism, making preference for quality over quantity in the Yoruba films. This research recommends adequate training for all actors, especially multilingual ones to increase their versatility, develop skill and technique in order to sustain them and increase their market value in the industry.
PENTINGNYA MEMBANGUN KOMITMEN KERJA SEBAGAI UPAYA MENINGKATKAN KINERJA MELALUI PENINGKATAN MOTIVASI, LINGKUNGAN, DAN KOMPENSASI
Authors: Anggraeni Fitria Nur
Published: January 2022

This study aims to analyze and prove the effect of compensation, work discipline and work environment on work motivation, both partially and jointly, and the effect of compensation, work discipline, work environment and work motivation on organizational commitment, both partially and collectively. The research method used in this research is descriptive survey method and explanatory survey with a population of 1,339 employees and a sample size of 224 respondents, and the data analysis method used is SEM (Structural Equation Modeling). Based on the results of the study, then obtained the findings of structure I, compensation and work environment is partially significant effect on work motivation, while labor discipline no significant effect, but together all exogenous positive and significant effect on work motivation with the value of the contribution (R2) by 50%. Partially, the compensation variable has the most dominant influence on work motivation. In the second structure, compensation, work discipline, work environment and work motivation partially and jointly positive and significant impact on faculty commitment to the value of the contribution (R2)equal to 76%. Partially, the compensation variable has the most dominant influence on lecturer commitment. The work motivation plays a role as partial mediating, where the increase in lecturer commitment is influenced by compensation and the work environment is mediated by work motivation. Meanwhile, work discipline can have a direct effect on lecturer commitment even though they are not motivated.
MENYIKAPI DAMPAK SOSIAL MEDIA DI TENGAH REMAJA, KELUARGA DAN MASYARAKAT DI MASA PANDEMI COVID 19
Authors: Rahmadania Siti Aisyah Nurrizqi , Nurismalastri Nurismalastri , Pratama Yuga , Aesah Siti , Prasetyo Djoko
Published: January 2022

Social media invites anyone who is interested to participate by giving feedback openly, giving comments, and sharing information in a fast and unlimited time. It is undeniable that social media has a great influence in one's life. Someone who starts small can make it big with social media, or vice versa. For the community, not only adults, but teenagers and children have become an addiction that makes users no day without opening social media. The focus of this community service is the role of the family in responding to the adverse effects of social media in the current covid 19 pandemic era where more time uses gadgets that are very closely related to social media, the focus of community service will be directed at the following two things: providing an understanding of the negative and positive influence of social media for adolescents, and how to respond to social media today to be able to deal with social media abuse wisely. This activity uses a lecture, discussion and training approach that refers to phenomenology. Location of activities at Bojongsari community organization, Depok. The conclusion of this activity is responding to social media interactions with the role of parents in supervising youth activities by limiting the time they use gadgets and paying attention to the age of teenagers to access content according to their age. The negative impacts of using social media on teenagers today are identity theft, cyber bullying, child and adolescent abuse, fraud, pornography, violence against children and adolescents, sexual exploitation, self-harm, panic/anxiety/low selfconfidence/stuttering. Social media, and addiction to social media and online games The positive impact of using social media on adolescents: Strengthening friendship relationships, Increasing income in daily life, Social media plays a role in conveying knowledge, Source of referrals and knowledge, Medium to speak, Awareness about surroundings and motivational, and entertainment media.Keywords : Social Media, Teenagers, Family
PENGENALAN AKUNTANSI DASAR PADA UMKM ROTI EYANG GUNA MENINGKATKAN SUSTAINABILITY
Authors: Nurmalasari Putri , Adiwibowo Akhmad Sigit , Ratnasari Fina
Published: January 2022

Pengabdian kepada masyarakat (PKM) ini bekerjasama dengan UMKM Roti Eyang yangberlokasi di jakarta. Tujuan dari PKM ini adalah untuk memberikan pembimbingan dan gambaran terntang pembuatan laporan keuangan kepada pemilik UMKM Roti Eyang bapak Suharso, karena pemilik UMKM Roti Eyang sangat antusias ingin mengetahui dasar-dasar akuntansi sehingga bisa membuat laporan keuangan sendiri. Kegiatan PKM ini dilaksanakan pada hari Sabtu, 24 April 2021 via zoom meet yang dihadiri oleh lima peserta, yaitu dari Universitas Pamulang dihadiri oleh tim dosen akuntansi, Putri Nurmala, S.E., M.Si., Akhmad Sigit Adiwibowo, S.E., M.Ak., dan Fina Ratnasari, S.E., M.Ak., selain itu dihadiri pula oleh dosen akuntansi ITB Swadharma, Rita, S.E., M.Ak.., dari UMKM Roti Eyang diwakili oleh pemiliknya, yaitu Bapak Suharso Sulistyo. Tujuan dari Kegiatan Pengabdian Kepada Masyarakat adalah untuk melaksanakan salah satu Tri Darma Perguruan Tinggi. Selain itu diharapkan dengan pengabdian kepada masyarakat tersebut keberadaan perguruan tinggi dapat memberikan kontribusi besar kepada pengembangan dan penerapan keilmuan kepada masyarakat.Kata Kunci: Sustainability, UMKM, Laporan Keuangan
PENGARUH TEKNOLOGI DALAM DUNIA PENDIDIKAN UNTUK GURU DAN PARA SISWA SMPN 13 DI TANGERANG SELAT
Authors: Jumhana R Chepy Safei , Sumali Achmad , Farida Syarifah Ida , Karlina Dira , Surasni Surasni
Published: January 2022

Kegiatan Pengabdian Kepada Masyarakat ini bertujuan untuk memberikan Pelatihan kepada Para Peserta Didik atau Siswa SMPN 13 Tangerang Selatan dalam memberi Pengetahuan tentang Perkembangan Teknologi Dalam Dunia Pendidikan meliputi Sejarah Perkembangan Teknologi, dan Dampak Dari PerkembanganTeknologi. Adapun metode yang dilakukan dengan penyampaian materi dan SimulasiAplikasi-aplikasi pembelajaran. Adapun hasil kegiatan pengabdian masyarakat memberikan pengetahuan tentang sejarah perkembangan teknologi, pengaruh yang diberikan dalam dunia Pendidikan serta dampak negative dari perkembangan teknologi, sehingga peserta didik khususnya Siswa SMPN 13 Tangerang Selatan langsung dapat merasakan dari pelatihan ini. Metode yang dilakukan dalam pengabdian Masyarakat yang dilaksanakandengan SMPN 13 Tangeran Selatan, didahului dengan tatap muka dengan Kepala Sekolah SMPN13 Tangerang Selatan untuk membicarakan permasalahan yang dihadapi dalam pelaksanaan pembelajaran jarak jauh di masa pandemi ini, agar pembelajaran tetap optimal walau dilaksanakan tanpa tatap muka, dengan memberikan materi pembelajaran dengan mensimulasikan aplikasi-aplikasi dan memanfaatkan media sosial agar pembelajaran menjadi menarik serta menumbuhkan kreatifitas Peserta Didik khususnya Siswa SMPN 13 Tangerang Selatan.Kata Kunci : PKM, Pengetahuan, Perkembangan Teknologi.
Motivasi dan Upaya Peningkatan Perekonomian melalui Wirausaha
Authors: Setyoningrum Ari Ani Dyah , Herdawan Deri
Published: January 2022

This study aims to provide an overview of the entrepreneurial motivations that encourage married women to become entrepreneurs and explore the efforts of women in entrepreneurship in improving their family economy. Entrepreneurship is a way that can help the family economy and become a self-actualization tool for women. This research was conducted with a qualitative approach. The sample of this research was selected by random sampling technique. The data were collected by using interviews, questionnaires and observation. The results of this study revealed that the motivation of women in entrepreneurship, among others, because of the desire to be economically independent, fulfilling the family's daily needs, spending spare time, utilizing existing places for business, hobbies, being motivated by other people, and having certain skills. Efforts to improve the family economy by entrepreneurship have a positive impact on improving the family's economic condition. With good financial management, the family's economic condition will improve. Entrepreneurial women share their income for several needs, including for the needs of their business continuity, family needs and investing.

 

Keywords: Entrepreneur, motivation, economy.
Pengaruh Bimbingan Kelompok dengan Teknik Diskusi dalam Meningkatkan Konsep Diri Positif Siswa
Authors: Marista Weli , Ferdiansyah M , Nurlela Nurlela
Published: January 2022

Self-concept is an individual's understanding of himself physically and psychologically including the advantages and disadvantages he has.   This study aims to determine the effectiveness of group guidance services using discussion techniques to improve students' positive self-concepts. This study uses a quantitative approach and the method used in this study is a pre-experimental design study with one group pretest and posttest design. This research was conducted at SMK Muhammadiyah 2 Palembang, and the samples of this research were students of class XII AKL 2 which amounted to 32 students after being given a pretest taken as many as 8 students who had a low positive self-concept. Sampling using a random sample technique. The results of the study were tested with the Wilcoxon Signed Rank Test statistic which was used to measure the significance of the difference between 2 groups in paired data on an ordinal or interval scale but with a non-normal data distribution. Based on the table of results of the Wilcoxon Signed Rank Test analysis, it can be seen that the Asymp probability number. Sig. (2-tailed) students' academic procrastination in doing assignments is 0.012, or the probability is below alpha 0.05 (0.012≤0.05). From the results obtained, Ho is rejected and Ha is accepted. Thus, it shows that group guidance with discussion techniques is effective in increasing students' positive self-concept.
A Study on Investors’ Perceptions towards Stock Market
Authors: Teoh Kok Ban , Restrepo Camilo Pérez- , López Carolina Ardila , Thulasedass Sharmila , S Chetana , Singh Padmalini , Suardi Elyoni Inez Sandra , Aryani Dwi Nita , Aggarwal Juhi , Das Abhijit
Published: January 2022

The stock market occurs from the interaction of a group of buyers (investors) and sellers of shares (companies), who represent ownership of the business. This includes a security listed on a public stock exchange under government supervision. Shares or stock market can be classified according to the country where the company is domiciled, for example Gudang Garam (company in Indonesia) which is domiciled in Indonesia and traded on the Indonesia Stock Exchange. The stock market has become an attractive and profitable investment today for investors and the stock market has grown rapidly over the years and is getting more and more attention because it deals with the future of money. However, a lot of investors are still worried to invest in stock market today, even investing in stock market results a huge profit. This reason can be the volatility in stock market. Therefore, this study focused on the investors’ perceptions towards stock market in different geographical areas. The data collected through online interview and distributing questionnaires to respondents in order to understand their behaviors, attitudes, desires, perspectives and level of awareness towards the stock market. The results showed that investors’ perceptions on buying shares in Asia are represented by several indicators, such as neutral information, accounting information, and social relevance, in which these three indicators generate impressions of the company’s activities based on profits and fundamental thinking patterns. Therefore, this will have an influence on investors in making decisions on the shares which will be chosen by them in the future.
Consumer Behavior Analysis on Online and Offline Shopping During Pandemic Situation
Authors: Espinoza Miguel Córdova , Ganatra Varsha , Prasanth Kiran , Sinha Rupesh , Montañez Corina Elena Ochoa , Sunil Kolhe Mayur , Kaakandikar Rishikaysh
Published: January 2022

Shopping has undergone a paradigm shift as a result of technological influence, with most consumers preferring online purchasing to traditional physical store shopping. The current pandemic scenario has resulted in a shift in customer spending patterns both online and offline. This paper identifies and analyses customers’ behavior towards online and retail shopping based on various factors affecting their behavior on which mode of shopping most they prefer during the pandemic situation. Primary data was used and a structured questionnaire was utilized to obtain the data. An online survey was conducted to collect from 200 heterogeneous kinds of people. The data collected were subjected to frequency analysis, Chi-square test, and Cronbach’s Alpha Test. IBM Statistical Package for Social Sciences (SPSS v23) was used for analyzing the data. The results revealed that among the various technological factors the proficiency rate of respondents utilizing, the internet has shown a significant impact on the consumers’ preference towards the mode of shopping. Factors like quick product information, a wider choice of products, better prices and discounts highly influence the consumers to opt for online shopping, whereas faster delivery time and product quality reliability and accuracy influence the consumers to choose offline shopping.
Smart Tourism Development Post Earthquake and Covid 19 Pandemic in West Nusa Tenggara
Authors: Nasution Dewi Sartika , Rahmawati Naili
Published: January 2022

One of the strategies that can be used to increase tourist visits after the earthquake disaster followed by the COVID-19 pandemic to West Nusa Tenggara is to utilize and apply information technology which is also known as the concept of smart tourism. This article aims to discuss smart tourism programs and applications in NTB. SWOT and Pest analysis method used to determine the relationship between external opportunities and internal strengths as well as internal weaknesses with external threats. Data was collected from interview with government tourism officer, observation and documentations. The results of the analysis can be used by the government or related parties in determining the direction of tourism development in NTB.
Customer's Purchase Decision in Alfamaret Tataaran II Minahasa
Authors: Manongko Allen A. CH. , Indawati Ninik , Oroh Silvana S.A , Kaparang Maria Melva
Published: January 2022

This study aims to determine the partial effect of service quality and price perceptions on customer buying decisions; and the simultaneous influence of service quality and price perception on customer buying decisions at Alfamart Tataaran II Minahasa. This research applied a quantitative approach with a survey method. The population comprised consumers who have made purchases at Alfamart Tataaran II Minahasa. The research sample consisted of 150 respondents selected by accidental sampling. The data were collected through questionnaires and analyzed by multiple regression. The findings reveal a significant effect of service quality on customer buying decisions, a positive and significant influence on price perceptions on customer buying decisions, and a collective positive influence and significant service quality and price perceptions on customer decisions.
Circulating Actin-Binding Proteins in Laryngeal Cancer: Its Relationship with Circulating Tumor Cells and Cells of the Immune System
Authors: Kakurina Gelena V. , Stakheeva Marina N. , Bakhronov Islombek A. , Sereda Elena E. , Cheremisina Olga V. , Choynzonov Evgeny L. , Kondakova Irina V.
Published: January 2022

We previously exposed the role of actin-binding proteins (ABPs) in cancer development and progression. In this paper, we studied the relationship between circulating ABPs and the number of ABP-expressing leukocytes and circulating tumor cells (CTCs) in patients with highly aggressive laryngeal squamous cell carcinoma (LSCC). The levels of cofilin (CFL1), profilin (PFN1), ezrin (EZR), fascin (FSCN1), and adenylate cyclase-associated protein 1 (CAP1) were determined using enzyme immunoassay. The ABP expression by the cellular pools was analyzed by flow cytometry. The highest levels of FSCN1 and EZR were found in the blood serum of LSCC patients. There was a difference in ABP expression between the pools of leukocytes and CTCs. Leukocytes were mainly represented by CAP1+ and FSCN1+ pools, and CTCs contained CAP1+, FSCN1+, and EZR+ cells. The serum FSCN1 level correlated with the number of FSCN1-containing and CFL1-containing leukocytes. Thus, the level of circulating EZR is likely related to its expression in CTCs. The levels of CFL1 and PFN1 are likely to be supported by the expression of these proteins by leukocytes. Both CTCs and leukocytes can be a source of FSCN1 and CAP1 in blood serum. The results suggest that serum proteins can be produced by various cells, thus indicating both cancer development and the response of the immune system to this process.
The Different Impact of ERK Inhibition on Neuroblastoma, Astrocytoma, and Rhabdomyosarcoma Cell Differentiation
Authors: Lebedev Timofey D. , Vagapova Elmira R. , Prassolov Vladimir S.
Published: January 2022

Aberrant ERK activity can lead to uncontrolled cell proliferation, immortalization, and impaired cell differentiation. Impairment of normal cell differentiation is one of the critical stages in malignant cell transformation. In this study, we investigated a relationship between ERK tyrosine kinase activity and the main differentiation features (changes in cell morphology and expression of genes encoding differentiation markers and growth factor receptors) in SH-SY5Y neuroblastoma, U-251 astrocytoma, and TE-671 rhabdomyosarcoma cells. ERK activity was assessed using a reporter system that enabled live measurements of ERK activity in single cells. We demonstrated that suppression of ERK activity by selective ERK inhibitors, in contrast to a commonly used differentiation inducer, retinoic acid, leads to significant changes in TE-671 cell morphology and expression of the myogenic differentiation marker genes PROM1, MYOG, and PAX7. There was a relationship between ERK activity and morphological changes at an individual cell level. In this case, SH-SY5Y cell differentiation induced by retinoic acid was ERK-independent. We showed that ERK inhibition increases the sensitivity of TE-671 cells to the EGF, IGF-1, and NGF growth factors, presumably by reducing basal ERK activity, and to the BDNF growth factor, by increasing expression of the TrkB receptor.
Evaluation of the Antiviral Potential of Modified Heterocyclic Base and 5’-Norcarbocyclic Nucleoside Analogs Against SARS-CoV-2
Authors: Matyugina Elena S. , Novikov Mikhail S. , Kozlovskaya Liubov I. , Volok Victor P. , Shustova Elena Y. , Ishmukhametov Aidar A. , Kochetkov Sergey N. , Khandazhinskaya Anastasia L.
Published: January 2022

The pandemic caused by the novel betacoronavirus SARS-CoV-2 has already claimed more than 3.5 million lives. Despite the development and use of anti-COVID-19 vaccines, the disease remains a major public health challenge throughout the world. Large-scale screening of the drugs already approved for the treatment of other viral, bacterial, and parasitic infections, as well as autoimmune, oncological, and other diseases is currently underway as part of their repurposing for development of effective therapeutic agents against SARS-CoV-2. In this work, we present the results of a phenotypic screening of libraries of modified heterocyclic bases and 5-norcarbocyclic nucleoside analogs previously synthesized by us. We identified two leading compounds with apparent potential to inhibit SARS-CoV-2 replication and EC50 values in a range of 2070 M. The structures of these compounds can be further optimized to develop an antiviral drug.
Extracellular Vesicles from Mycoplasmas Can Penetrate Eukaryotic Cells In Vitro and Modulate the Cellular Proteome
Authors: Mouzykantov Alexey A. , Rozhina Elvira V. , Fakhrullin Rawil F. , Gomzikova Marina O. , Zolotykh Maria A. , Chernova Olga A. , Chernov Vladislav M.
Published: January 2022

The extracellular vesicles (EVs) produced by bacteria transport a wide range of compounds, including proteins, DNA and RNA, mediate intercellular interactions, and may be important participants in the mechanisms underlying the persistence of infectious agents. This study focuses on testing the hypothesis that the EVs of mycoplasmas, the smallest prokaryotes capable of independent reproduction, combined in the class referred to as Mollicutes, can penetrate into eukaryotic cells and modulate their immunoreactivity. To verify this hypothesis, for the first time, studies of in vitro interaction between human skin fibroblasts and vesicles isolated from Acholeplasma laidlawii (the ubiquitous mycoplasma that infects higher eukaryotes and is the main contaminant of cell cultures and vaccines) were conducted using confocal laser scanning microscopy and proteome profiling, employing a combination of 2D-DIGE and MALDI-TOF/TOF, the Mascot mass-spectrum analysis software and the DAVID functional annotation tool. These studies have revealed for the first time that the extracellular vesicles of A. laidlawii can penetrate into eukaryotic cells in vitro and modulate the expression of cellular proteins. The molecular mechanisms behind the interaction of mycoplasma vesicles with eukaryotic cells and the contribution of the respective nanostructures to the molecular machinery of cellular permissiveness still remain to be elucidated. The study of these aspects is relevant both for fundamental research into the logic of life of the simplest prokaryotes, and the practical development of efficient control over hypermutable bacteria infecting humans, animals and plants, as well as contaminating cell cultures and vaccines.
Determination of a potentially optimal zone to perform hydraulic fracturing work, Upper Magdalena Valley basin, Colombia
Authors: Sánchez Carlos Fabián , Molina Indira , Molina Gabriel Ángel
Published: January 2022

The present study was carried out for an oil field located in the upper Magdalena Valley basin, Colombia, in which successful hydraulic fracturing was carried out in a well, which we denote fractured. The main objective is to replicate this technique in an existing well in the same field. For this work, electrical logs from twelve  wells, including the fractured well, were analyzed to obtain a correlation between the area of interest, located  in the Monserrate Formation, and each of the wells under study. By using gamma ray, resistivity, neutron and  density logs, the petrophysical properties were calculated to determine the shale volume, effective porosity,  total porosity, water saturation and permeability in each well. Additionally, the production history of each of  the wells and the calculations described above were used to suggest a new site where hydraulic fracturing  could also be successful. Two candidates were proposed in this study, one based on the similarity of its  petrophysical properties, and another based on the consideration of additional production data. Notably, this well stimulation technique has global importance and has produced positive impacts on increased oil  production where it has been implemented. The purpose of this study is to provide technical support for the  decision to replicate this procedure in a new area of the field.
Micro ambientes de aprendizaje para potenciar las habilidades lingüísticas
Authors: Cajamarca Dayana , Sucuzhañay Joselyn , Pizarro Estefania , Andrade Luis , Portela Juan
Published: January 2022

En este artículo se aborda el diseño y aplicación de cinco micro ambientes de aprendizaje, cada uno con su respectivo bloque curricular de Lengua y literatura, a través de la implementación de metodologías activas, tales como: Learning by doing, Flipped Classroom, Aprendizaje basado en problemas y el Aprendizaje basado en juegos, para dar una solución al déficit de habilidades lingüísticas en estudiantes del nivel superior, que corresponden a los tres primeros años de colegio o secundaria. Para el desarrollo de esta investigación se utilizó un paradigma sociocrítico con un enfoque cualitativo, empleando técnicas tales como: la observación participante, encuestas y entrevistas con sus respectivos instrumentos que fueron aplicados a diferentes integrantes de comunidades educativas en el área de Lengua y Literatura.
Contribución de un programa de formación continua a las concepciones epistemológicas en docentes de química
Authors: Villegas Fernández Sandra , Cuellar Fernández Luigi
Published: January 2022

El presente artículo se enmarca en una investigación con un grupo de docentes de Química de educación secundaria chilena que participaron en talleres de formación continua. El objetivo de este estudio fue caracterizar la evolución de las concepciones epistemológicas sobre la naturaleza de las ciencias y la importancia de la fundamentación metadisciplinar para el mejoramiento de las prácticas docentes. A partir de la investigación, de carácter cualitativa con un enfoque descriptivo en un estudio de casos colectivo, queda en evidencia que el conocimiento de las concepciones epistemológicas vinculadas a la naturaleza de las ciencias, en el marco de una comunidad de aprendizaje, permiten resaltar la importancia de promover la reflexión docente y el cambio en su discurso pedagógico.
Phytoremediation of soils contaminated with crude and weathered oil using two rice varieties (Oryza sativa L.)
Authors: Morales Gilberto , Rivera-Cruz María del Carmen , Ferrera-Cerrato Ronald , ZAVALA-CRUZ JOEL , Ramos Reyes Rodimiro
Published: January 2022

Objective: To evaluate the potential for soil phytoremediation with new and weathered hydrocarbons with two rice varieties (Oryza sativa L.).
Materials and Methods: The assessed treatments were 150 mg kg-1 (control soil), 30,000; 60,000 and 90,000 mg kg-1 of new oil and 79,457 mg kg-1 of weathered oil 1 and 42,000 of mg kg-1 of weathered oil 2; they were established in a completely randomized design with 6 x 3 factorial, with four repetitions each. The evaluated variables were populations of total bacteria (colony forming units CFU per grams of dry soil), free-living nitrogen-fixing bacteria (CFU), total fungi (CFU), and total dry biomass (g). Total bacteria and fungi were quantified at the beginning of the experiment at 90 and 145 days.
Results: The highest total petroleum hydrocarbons (HTP) degradation was 73 and 72 % in the 79,457 and 42,000 mg kg-1 concentrations of weathered HTP 1 and 2, in the rhizosphere of rice silver line 21. The total dry biomass reported significant differences (p ≤ 0.05), evidencing a lower effect in the 60,000 mg kg-1 concentration in new oil, which caused a 33 % reduction compared to the control.
Results/Conclusions: The rice variety line 21 has a greater potential to phytoremediate soils contaminated with crude and weathered oil in field conditions in tropical areas.
FORECASTING AND ON THE INFLUENCE OF CLIMATIC FACTORS ON RISING DENGUE INCIDENCE IN BAGUIO CITY, PHILIPPINES
Authors: Marigmen Joseph Ludwin De Castro , Addawe Rizavel Corsino
Published: January 2022

Dengue fever or dengue has been a concern for individuals living in Baguio City, Philippines. Every year, incidence counts rise during rainy seasons experienced from June to October. Several researches suggest that meteorological factors have great influence on the life, growth, and reproduction of dengue-carrying mosquitoes, resulting in higher dengue incidence in the area. With the continuing rise of dengue incidence in Baguio City, we aim to forecast dengue incidence in the area for the year 2019, starting from January until the end of the outbreak period in the area. Here, we use the projections package of R as it involves the serial interval distribution and 𝑅𝑡 value of dengue incidence. We also aim to use multiple linear regression analysis to determine if meteorological factors have significant effects in the rise of dengue incidence in the city. With the inclusion of time-varying reproduction number and serial interval distribution of dengue, we projected that dengue incidence may reach up to 101 cases by June 16, 2021, and without further actions, cases may rise up to 529 cases by August 29, 2021. Based on the average two-year period, such increase is attributed to relative humidity and average temperature as these are the most significant factors associated with dengue incidence based on the MLR analysis. The highest and mean maximum temperatures remain as key meteorological variables that influence dengue incidence in the city. As early as possible, local officials are recommended to uphold proper safety and health procedures in preventing the spread of dengue in Baguio City.
We Want Them, but We Will Not Support Them: A Comparative Study of Settlement Services Provided to International Students in the USA and Canada
Authors: Dadabhoy Sahar
Published: January 2022

In recent years, the number of international student’s to the USA has plateaued, with many International Students now choosing to migrate to Canada instead. Arguably, for its world-renounced education from leading post-secondary institutions, as well as possible pathways to Canadian citizenship. The Canadian government has also been quick to recognize the lucrative contributions of international students to the Canadian economy, even expanding immigration policies to create express pathways to citizenship for international students. Despite this, emerging research shows that international students find it difficult to adopt during their time in North America, and face challenges that can potentially hinder their long-term retention in Canada (Chevrier, 2019). Thus, using a comparative and integrative literature review, this research study assesses the structure of settlement service delivery, and current gaps that hinder the delivery of comprehensive settlement programs for international students in the USA and Canada. The findings of this review show that the American and Canadian governments have not taken an active role in supporting international students, and instead downloaded the responsibility of settlement service delivery to post-secondary institutions. Furthermore, privatization of services in America has been somewhat successful, while in Canada it has been largely unsuccessful. The implications of these research findings is that, if Canada wants to continue to retain its ISs population, it must ensure it is doing its part to support the short, and long-term resettlement and integration of international students into Canadian society.
Impact of Artificial Intelligence on Professional Autonomy of Pathologists
Authors: Feroze Saman
Published: January 2022

Advancements in Artificial Intelligence (AI) are paving the way to applications in pathology, with the hope of making significant contributions towards patient care. The prospect of implementation in clinical practice also raises organizational and ethical questions. Professional autonomy of pathologists is the freedom to make prognostic and diagnostic decisions independently that best meets the needs of patients. Researchers have highlighted some of the potential impacts of AI on professional autonomy. However, it is not clear how individual pathologists perceive its potential impact on their own practice.

The purpose of this study is to investigate the perspective of pathologists on the impact of Artificial Intelligence on their professional autonomy. The results of this study highlight the ethical concerns of pathologists related to decision making bias and their retroactive monitoring. Results also highlight the importance of curriculum and policy interventions to build upon technical knowledge and skills of pathologists and to have control over the process of validation and regulatory processes of AI tools and that these tools might make pathologists more objective and less mindful of resources.
Examining Considerations of Social Sustainability And Equity Within Integrated Community Sustainability Plans in Ontario
Authors: Güvenç Sabrina
Published: January 2022

The concepts of sustainability, and sustainability planning, have become prominent in the last thirty years. In 2005, the Canadian government created a budget plan that was intended to fund infrastructure projects in municipalities across the country, as well as catalyze and strengthen sustainability planning within municipalities across the nation. In order for municipalities to receive the funding they needed to create Integrated Community Sustainability Plans (ICSPs) or provincial variants (ex. strategic sustainability plans). This thesis comparatively analyzes select integrated community sustainability plans in the Province of Ontario, Canada with specific focus placed on how and whether ICSPs address, define and advance social equity goals and principles in sustainability planning. Two questions drive the research: 1) How have ICSPs considered equity principles in their design and implementation; and, 2) How does variation in the degree of community involvement in sustainability planning influence how equity is addressed? This study draws upon qualitative methods including a comparative document analysis of ICSPs in Ontario and semi-structured key informant interviews. The overall findings suggested that equity was not strongly considered in the ICSPs analysed. There were few key results that emphasised this. Firstly there was a disconnect between policy goals and details within implementation strategies. There was found to be a lack of prioritization of equity, particularly with meaningful consideration of distributional equity. Lastly a lack of prescriptive guidance by the federal government and FCM with respect to goals and implementation.
The Mental Health Impacts of Immigration Detention Centers On Asylum Seekers: A Comparative Analysis of Canada and the United States
Authors: Hashimi Abid
Published: January 2022

This paper is a literature review examining the mental health impacts that immigration detention centers have on asylum seekers in Canada and the United States (US). Drawing evidence from the social exclusion framework, it assesses explicitly the negative connotation of being isolated from society. The review focuses on the inability of detention centers in dealing with asylum seekers with pre-existing mental health conditions; how inadequate access to proper health care contributes to extending their existing mental health concerns; and how detention centers resemble forced confinement and contribute to family separation adding to the trauma of detainees, specifically children. In addition, this paper recommends that Canada and the US must adopt Alternatives to Detention (ATD) with a specific focus on Community Based Programs as policy adjustments to deal with asylum seekers effectively.
Feedback-Seeking Behaviour and Leader Support: An Attachment Theory Perspective
Authors: Hymas Laura
Published: January 2022

Organizations rely heavily on human capital to succeed and maintain competitive advantage in today’s fierce economic environment. Organizations that make effective use of feedback practices have greater business growth and more productive employees. In this thesis, I apply Attachment Theory to organizational research to more thoroughly understand working relationships and proactive behaviour. My study explores the relationship between attachment style and frequency of feedback-seeking behaviour, and the impact of leader support. Examining these relationships is important because feedback sharing is a critical tool in the workplace to encourage improved workplace behaviour and performance, however, there is a critical gap in the literature regarding the factors that encourage or discourage this behaviour. The results demonstrate a positive relationship between attachment anxiety and frequency of feedbackseeking, and a negative relationship between attachment avoidance and frequency of feedbackseeking, although neither finding is significant. Further, the interaction effect of leader support was also not significant. Future research should consider replicating the study and making appropriate modifications to mitigate limitations such as sample size and selection bias.