bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthetic Frog-Derived-like Peptides: A New Weapon against Emerging and Potential Zoonotic Viruses
Authors: Chianese Annalisa , Iovane Valentina , Zannella Carla , Capasso Carla , Nastri Bianca Maria , Monti Alessandra , Doti Nunzianna , Montagnaro Serena , Pagnini Ugo , Iovane Giuseppe , De Filippis Anna , Galdiero Massimiliano
Published: August 2023

Given the emergence of the coronavirus disease 2019 (COVID-19), zoonoses have raised in the spotlight of the scientific community. Animals have a pivotal role not only for this infection, but also for many other recent emerging and re-emerging viral diseases, where they may represent both intermediate hosts and/or vectors for zoonoses diffusion. Today, roughly two-thirds of human infections are derived from animal origins; therefore, the search for new broad-spectrum antiviral molecules is mandatory to prevent, control and eradicate future epidemic outbreaks. Host defense peptides, derived from skin secretions of amphibians, appear as the right alternative to common antimicrobial drugs. They are cationic peptides with an amphipathic nature widely described as antibacterial agents, but less is reported about their antiviral potential. In the present study, we evaluated the activity of five amphibian peptides, namely RV-23, AR-23, Hylin-a1, Deserticolin-1 and Hylaseptin-P1, against a wide panel of enveloped animal viruses. A strong virucidal effect was observed for RV-23, AR-23 and Hylin-a1 against bovine and caprine herpesviruses, canine distemper virus, bovine viral diarrhea virus, and Schmallenberg virus. Our results identified these three peptides as potential antiviral-led candidates with a putative therapeutic effect against several animal viruses.
The Role of Epinephelus coioides DUSP5 in Regulating Singapore Grouper Iridovirus Infection
Authors: He Jiayang , Cai Yijie , Huang Wei , Lin Yunxiang , Lei Yurong , Huang Cuifen , Cui Zongbin , Qin Qiwei , Sun Hongyan
Published: August 2023

The dual-specificity phosphatase (DUSP) family plays an important role in response to adverse external factors. In this study, the DUSP5 from Epinephelus coioides, an important marine fish in Southeast Asia and China, was isolated and characterized. As expected, E. coioides DUSP5 contained four conserved domains: a rhodanese homology domain (RHOD); a dual-specificity phosphatase catalytic domain (DSPc); and two regions of low compositional complexity, indicating that E. coioides DUSP5 belongs to the DUSP family. E. coioides DUSP5 mRNA could be detected in all of the examined tissues, and was mainly distributed in the nucleus. Infection with Singapore grouper iridovirus (SGIV), one of the most important pathogens of marine fish, could inhibit the expression of E. coioides DUSP5. The overexpression of DUSP5 could significantly downregulate the expression of the key SGIV genes (MCP, ICP18, VP19, and LITAF), viral titers, the activity of NF-κB and AP-I, and the expression of pro-inflammatory factors (IL-6, IL-8, and TNF-α) of E. coioides, but could upregulate the expressions of caspase3 and p53, as well as SGIV-induced apoptosis. The results demonstrate that E. coioides DUSP5 could inhibit SGIV infection by regulating E. coioides immune-related factors, indicating that DUSP5 might be involved in viral infection.
A Subunit Vaccine Candidate Composed of Mpox Virus A29L, M1R, A35R, and B6R Elicits Robust Immune Response in Mice
Authors: Yang Xuetao , Yang Xidan , Du Shouwen , Hu Congxia , Yang Xiu , Wang Xingyun , Hu Xing , Rcheulishvili Nino , Wang Peng George , Lin Jihui
Published: August 2023

With no specific antiviral drugs and preventive vaccines against Mpox virus (MPXV), the epidemic has led to the declaration of a Public Health Emergency of International Concern. As a developmental direction for new vaccines, studies of subunit vaccines based upon MPXV antigen proteins are lacking. In this study, A29L, M1R, A35R, and B6R of MPXV were expressed and purified from a prokaryotic system. The four MPXV antigen proteins in combination were mixed with aluminum hydroxide or CpG7909 as adjuvant, and subsequently used to inoculate mice. The results of enzyme-linked immunosorbent assay (ELISA), flow cytometry analyses, and enzyme-linked immunospot (ELISPOT) assays indicated that A29L, M1R, A35R, and B6R elicited high-level antigen-specific antibodies and CD4+ T cells-based cellular immune response in mice. Moreover, the results of virus neutralization assays suggested that sera from the mice immunized with four proteins elicited high neutralizing activities against the vaccinia virus. Notably, the results of ELISA, ELISPOT, and virus neutralization assays also showed that the CpG7909 adjuvant was more effective in inducing an immune response compared with the aluminum adjuvant. In summary, this study offers valuable insights for further studies of subunit vaccine candidates for the prevention of MPXV and other orthomyxoviruses.
Investigation of Structural Strength and Fatigue Life of Rotor System of a Vertical Axial-Flow Pump under Full Operating Conditions
Authors: Li Haoyu , Cai Zhizhou , Zheng Yuan , Feng Jiangang , Xu Hui , Chen Huixiang , Binama Maxime , Kan Kan
Published: August 2023

Axial-flow pumps consider both the conventional pump mode and the pump as turbine (PAT) mode operation and put forward higher requirements for long-term operation stability and structural strength; therefore, it is of great engineering significance to evaluate the structural strength and fatigue life of the rotor under full operating conditions. In this study, based on computational fluid dynamics and the one-way fluid-structure interaction algorithm, the structural strength and fatigue life of the rotor system of a large vertical axial-flow pump under full operating conditions were evaluated and studied. The results show that blade deformation and equivalent stress are generally higher in the PAT mode than in the pump mode. The maximum deformation in both modes occurs at the tip of the blade, while the area of stress concentration is at the root of the blade. Both the deformation and the equivalent stress increase with increasing flow rate. The minimum safety factor occurs at the blade root in both modes, and the safety factor in the PAT mode is relatively smaller than that in pump mode. Therefore, when designing and manufacturing axial flow pumps for turbine duties, priority should be given to material strength at the blade root during PAT mode operation to ensure safe and stable operation. The aim of this study is to provide technical references and theoretical foundations for evaluating the service cycle of axial-flow pumps and the influence on pump life under different operation modes.
Estimated Impacts of Smart Water Meter Implementation on Domestic Hot Water Consumption and Related Greenhouse Gas Emissions from Case Studies
Authors: Msamadya Spancer , Joo Jin Chul , Lee Jung Min , Lee Sangho , Kim Sangrae , Go Hyeon Woo , Lee Seul Gi
Published: August 2023

This study investigates the water–energy–carbon (WEC) nexus in cities across four countries, namely the United Kingdom (UK), the United States of America (USA), Australia (AUS), and South Korea (KOR), over a decade, from 2011 to 2021. The primary objective is to assess the impact of smart water metering (SWM) implementation on the WEC nexus, with a specific focus on domestic hot water (DHW) consumption and associated greenhouse gas (GHG) emissions. The analysis of the collected data reveals diverse patterns among cities with varying levels of SWM implementation. Notably, cities with higher SWM implementation demonstrated significant reductions in water consumption, indicating the effectiveness of the efficient water consumption and demand management achieved through SWM. The study emphasizes the importance of addressing GHG emissions related to water heating, with the carbon intensity of water heating identified as a critical factor in this context. To achieve net reductions in GHG emissions, intensive efforts are required to simultaneously decrease both DHW consumption and the carbon intensity of water heating. The research findings highlight the potential for substantial GHG emissions reductions by combining SWM implementation with the decarbonization of water heating. By recognizing the interdependencies within WEC systems, this study underscores the significance of SWM in advancing toward a carbon-neutral society. In conclusion, this study contributes valuable insights into the WEC nexus and emphasizes the role of SWM in achieving sustainability goals. It advocates for integrated policies to effectively address the interconnected issues of the WEC nexus for effective climate change mitigation.
Determinants of Water Consumption in Hotels: New Insights Obtained through a Case Study
Authors: Antonova Natalia , Mendoza-Jiménez Javier , Ruiz-Rosa Inés
Published: August 2023

The literature on water use in hotels has identified numerous determinants of water consumption, but a consensus has yet to be reached on the influence of some of these factors. This article aims to enhance the current research framework on water use in the hotel sector by presenting a case study of one hotel in Tenerife, Canary Islands. The conceptual framework of water consumption in hotels is presented based on the previous literature. Starting from that, basic statistical analysis and bivariate correlations were performed on water consumption data from 2007 to 2019 to determine the significant factors affecting both total water consumption and consumption per guest night. Special attention was paid to water usage in gardens and the impact of weather conditions, as there is a lack of research focused on them. Additionally, the water management actions of the hotel were classified according to the business’ themes proposed for the Sustainable Development Goals, using an internationally recognized guide, thus addressing one of the gaps identified in the literature. The results generally support previous research findings, but some discrepancies were noted regarding the number of guest nights and the effectiveness of implementing water-saving measures. This raises new questions about the characteristics of various water-saving measures, such as room renovation, and their influence on customer behavior, which may alter the intended impact on water consumption. Therefore, the findings of this study can provide an insight into unclear aspects in this area. They could also benefit hotels in terms of sustainability communication by allowing them to position their actions with an internationally recognized framework.
SPECIES COMPOSITION OF COCCINELLIDAE (COLEOPTERA, COCCINELLIDAE) IN CHOCHETS URBAN VILLAGE EDGE, CHUHUIV DISTRICT, KHARKIV REGION
Authors: Dekhtiarova O.
Published: August 2023

During the field research conducted in 2018-2020, the species composition of coccinellidae in the selected area was determined. We had conducted a comparative analysis of accounting for quantitative and taxonomic composition over the years of the study. We had studied the biology and ecology of each species, including the trophic relationships of each species. The main food groups of coccinellidae had been identified depending on the food objects, biotope distribution, and their main ecological groups had been identified.The analysis of accounting tables showed that in the Kochetok village there is a great variety of species quite common to the Kharkiv region. In the entomofauna of the Kharkiv suburbs were detected 15 species of coccinellidae beetles which belong to 11 genera. Of the 15 species of coccinellidae, it was found that Coccinella septempunctata L. and Harmonia axyridis Pall. are dominants, and Adalia bipunctata L. and Hippodamia tredecimpunctata L. are subdominants. We had been studied the ecological and biological features of each identified species, including trophic relationships.We had given the economic assessment of the coccinellidae, marked the species promising for the control of plant pests, and developed the recommendations on the protection of local coccinellidae species and the methods of increasing their number and efficiency.
THE ROLE OF PLAY IN BUILDING RELATIONSHIPS BETWEEN PEERSIN THE PRESCHOOL GROUP
Authors: Marzec H.
Published: August 2023

The main purpose of the article is to study the importance of plays in building relationships between peers. The method of diagnostic survey was used to conduct the research, the research technique was a survey, and the tool was a questionnaire. The projective technique was also used. Its tool was the test of unfinished sentences. The play has a significant role in building relationships between peers in a preschool group. The child's adaptation to the new environment is also of great importance here. It is because the relations between the charges are also conditioned by a friendly atmosphere and positive attitude toward peers, teachers, and the institution. Children's attitude towards preschool is usually positive, and no negative feelings are noticed among children. It means that preschoolers feel good in the facility they attend. They like it, and they love playing with each other. Although, sometimes, there are aggressive behaviors to which the teacher should react appropriately. Positive relations between the teacher and the child are essential elements of a properly functioning preschool institution. Teachers know about this sympathy; they know that children take their personalities into account. Good relations with peers and appropriate contact with the teacher are also the most crucial factors in building relationships between children; the atmosphere in the facility is also significant, as the environment, the organization of the teacher's work, the level of the child's development, or the equipment of the facility.
Cümcümenāme’de Gönderimsel Bağlaşıklık
Authors: GÜLER Emine
Published: August 2023

Çağdaş metin dil bilimi çalışmaları doğrultusunda “anlamsal/yapısal bütünlük taşıyan ve bir iletisi olan sözler birlikteliği” olarak tanımlanabilecek olan metin kavramının önemi artmıştır. Gerek metin olanla olmayanı ayırt etmede gerekse yeni metin oluşturmada metinsellik ölçütlerine uyulup uyulmadığının belirlenmesi gerekir. Temelde bağlaşıklık ve tutarlılık olarak iki ana başlıkta ele alınan metinsellik ölçütleri; sözlü, yazılı veya görsel malzemenin metin niteliği taşıyıp taşımadığının tespitinde önemlidir. Özellikle tarihî Türk lehçelerine ait eserlerde, işlenen konuların farklı coğrafyalarda kimi zaman bazı farklılıklarla yer alması ve çağlarını aşması eser kurgularının metinsellik ölçütlerini karşıladığını göstermektedir. Çalışmanın konusunu teşkil eden Harezm Türkçesi eseri Cümcümenâme; Anadolu ve Çağatay sahalarında da nüshaları bulunan manzum bir mesnevidir. Çok bilinen bir halk hikayesiyle de (Kesikbaş Destanı) konu bakımından benzerlik göstermektedir. Eserin metinsellik ölçütlerini karşılıyor olması ve kurgusal yapısı; içeriğin yayılmasını kolaylaştırmış, sözlü geleneğe de katkı sunmuştur. Çalışmada eser, metinsellik ölçütlerinden gönderimsel bağlaşıklık açısından incelenecek ve gönderimsel bağlaşıklığı sağlamada yararlanılan sözcük türleri; öncül/bağımsız, ardıl/bağımlı olma niteliklerine göre dış ve iç gönderim (eş gönderim/art gönderim/ ön gönderim) açısından ele alınacaktır. Böylelikle bağlaşıklık ölçütünün eserin akıcılığına etkisi belirlenmeye çalışılacaktır.
A New Polygonatum, P. bifolium species (Asparagaceae: Nolinoideae: Polygonateae) from Myanmar and a Checklist of the Species Known to Occur There
Authors: Floden Aaron , Yu Nwe Thet , Armstrong Kate E.
Published: August 2023

A new species of Polygonatum Mill., P. bifolium Floden & K. Armstr. (Asparagaceae), is described and illustrated from northern Myanmar, Kachin State, Putao District. Polygonatum bifolium is highly distinctive in that the mature plant consists of two opposite leaves with a single flower borne between these. It occurs as an epiphyte at mid-elevations from ca. 2000 to 2500 m. It is the smallest species of Polygonatum thus far discovered. A conservation assessment is provided based on the available data and several collections with a proposed IUCN status of Vulnerable [VU D2]. We provide a preliminary list of the described species that are known to be present in Myanmar and taxonomic notes on each. Lastly, we provide a lectotypification for P. nervulosum Baker, which should be expected in Myanmar.
Study of Pottery Technology in Kura-Araxes Culture of Astanakroud 2 Site of Kojur County Using Petrographic Method
Authors: REZAEI Mohammad Hossein , MASJEDI KHAK Parastoo , MOTAVALI RAMEH Ali
Published: August 2023

The pottery samples under investigation in this study include the findings of the Astankroud 2 Site in the Kojur region of western Mazandaran Province. The site was uncovered during an archaeological survey of the region in 2010 and has been thus far the easternmost site of Kura-Araxes. Considering the importance of discussions concerning the characteristics of this culture and the reasons for its spread in a vast geographic area extending from the southern coast of the Caspian Sea to the eastern shores of the Mediterranean Sea, 15 pottery pieces of Kura-Araxes were subject to petrographic study in order to determine the mineralogy structure of the pottery recovered from Astanakroud Site. The experiments on these pieces were conducted using a polarizing microscope (James Swift) at the Petrographic Laboratory of the Institute for Protection and Restoration of Works affiliated with Cultural Heritage Research. According to the results of experiments, it was revealed that all the pottery had been locally produced. A petrographic study of Astanakroud pottery reveals that the pottery has been produced using soil resulting from erosion of geological structure in the northern part of the Kojur region (with volcanic structure) that has been washed up by natural currents traversing the valleys of Nimvar, Avil, and Kouhpar to the foot of the site.
A systematic survey of Ardashir Palace’s Stronghold at Tol-e Khezr, Firuzabad Plain in Fars Province, Iran
Authors: ABBASNIA Homayoun , ASKARI CHAVERDI Alireza
Published: August 2023

This research investigated the archaeological site of Tol-e Khezr in Firuzabad with the purpose of establishing a relative chronology. This site is among those whose pottery has been less extensively studied, and it also boasts a strategic location. Therefore, the site of Tol-e Khezr was selected for systematic sampling and investigation of its structures to ascertain its relative chronology and usage as accurately as possible. A methodical approach was chosen for the investigation of Tol-e Khezr, consisting of three steps: mapping, sampling, and documentation of the findings (including washing the pottery, registering the pottery fragments, entering the information of the findings into SPSS software, selecting the diagnostic samples, drawing the diagnostic samples, and photographing the samples). In this methodical way, 50% of all grids were sampled, with the form of every other grid. This included 30 grids of 10 x 10 meters. The number of all gathered pottery comprised 644 pieces. To interpret the pottery, we considered 12 variables for them, and the information on each piece was entered into the Statistical Package for the Social Sciences (SPSS) according to these variables. One of the most essential classifications relates to the typology of Tol-e Khezr pottery forms, which parallels various surveyed and excavated areas' findings in Iran and beyond. Furthermore, the survey revealed that, in addition to typical pottery, three distinct types of ceramic were identified: coarse with raised bands, glazed (alkaline), and ceramics with a dark slip coating. At this firm, architecture and its details in visible and exposed areas were documented, described, analyzed, and compared.
Disclosure of Governance, Ownership Structure, Earnings Quality, and Future Performance (Evidence from Indonesia and Singapore)
Authors: Fambudi Imam Nurcahyo , Murwaningsari Etty
Published: August 2023

This study analyzes the effect of institutional ownership structure and earnings quality on the future performance of companies with governance as a moderating variable in Indonesian and Singaporean companies. The company's future performance in general will usually be represented in the financial statements. Earnings quality is an important benchmark for companies to determine the quality of company accounting information. Institutional ownership is sharing ownership owned by an institution or business entity. Institutions here can mean ownership by banks, foundations, investment fund managers, pension fund managers, and others. Good Corporate Governance is corporate governance that explains the influence between various participants in the company that determines the direction of the company's future performance. The sample used in this study are companies listed on the Indonesia Stock Exchange and Singapore Stock Exchange from the period 2018 to 2020. This study uses a multiple linear regression model. The results show that institutional ownership structure has a significant positive effect on Future Performance and governance. as an independent variable shows a significant positive result on Future Performance.
PERKIRAAN JUMLAH PENDUDUK OPTIMAL DAMPAK ADANYA PERGURUAN TINGGI BARU DI KABUPATEN PEKALONGAN
Authors: Hariwibawa Arga Prinandiga
Published: August 2023

The existence of the attraction zone in the form of infrastructure facilities and infrastructure supporting community activities is a special attraction for the community to build a residence in Pekalongan Regency. This triggered the population growth of Kajen District, which continued to peak; in the 2020–2022 range, there was an increase in the population of more than 75,000 people. The results of the analysis stated that the area of ​​Pekalongan Regency which covers 83,615 ha, as much as 52% of the area is a cultivation area. The remaining 35% is a buffer area, and 14% of it is an area with a protected function. This article is intended to estimate the maximum population that can be accommodated in Pekalongan Regency due to the existence of a new university, so that it will not have a negative impact on the environment . Meanwhile, to estimate this, data analysis methods are used by utilizing tools in the form of GIS and land carrying capacity calculations based on the determination guidelines carriage capacity and capacity environment. In accordance with the analysis of the carrying capacity of residential land functions in Pekalongan Regency, it was found that it currently has a DDPm value of 16.96. This represents that Pekalongan Regency is still very capable of supporting population growth.
DINAMIKA PEMANFAATAN TANAH ULAYAT DALAM PEMBANGUNAN PERUMAHAN
Authors: Perdana Lalu Rizky Putra , Swasto Deva Fosterharoldas
Published: August 2023

The construction of this housing is carried out as an effort to meet the demands of the needs of the community which is increasing and growing. All regencies/cities are quite intense giving permission to developers to build housing in their area. One of the most popular locations is the one located in the South Gerung area. In line with the development of regional development, it must be open to seeing the issue of existing progress, therefore as a superior area because of a district capital. The implication of the development of the region is the emergence of various problems including the conflict of spatial use that can threaten the continuity in the area. This makes a new conflict related to housing residents as a new citizen when the fellowship and so on, this will occur a problem or confusion related to its resolution. This study uses qualitative methods, the data obtained for this study are interviews and secondary data. The results of this study found a number of related conceptualizations of the first dynamics of factors, namely which discusses how the beginning of a conflict and what is behind this conflict occurs, the second dynamics of conflict is related to how the impact that occurs and is felt by the surrounding community in housing as a result of conflict And disputes occur so that they find the impact of periodic and temporary, the three dynamics of resolution related to conflict mediation and actors involved where in this section discusses how in the form of the Bale Mediation institution after previously mediating conflict in a personal way with the figures, and in this case involved There are also those from individuals and groups.
 
Keywords: conflict and resolution, customary land, housing
HEMODYNAMIC CHANGES IN NICKEL INTOXICATION AND THEIR EXPERIMENTAL CORRECTION WITH ORGANIC SELENIUM AND SMALL DOSES OF ZINC
Authors: Oganesyan David , Brin Vadim , Kabisov Oleg
Published: August 2023

The purpose of the study is to investigate the effect of organic selenium and low doses of zinc on nickel intoxication. Selenium and zinc were administered once daily at a dose of 4 and 1 mg/ kg. Nickel chloride (5 mg/kg) was administered intragastrically using a probe, daily for one month. At the end of the experiment time (30 days), the main parameters of systemic hemodynamics were determined. The arterial blood pressure from the femoral artery was measured and the mean (MAP) was calculated. Cardiac output was determined by thermal dilution, heart rate (HR) was recorded; cardiac index, shock index and specific peripheral vascular resistance were calculated using special formulas. Our findings showed that nickel leads to significant disruptions in hemodynamics and heart function of rats, manifested in an increase in MAP, a change in heart rate, a decrease in systolic output. The introduction of selenium or small doses of zinc in rats exposed to nickel, produced a noticeable decrease in the cardiotoxic effects of this metal. There was also a decrease in the hypertensive effect of the metal. Thus, it has been established that antioxidants selenium and zinc can effectively reduce nickel toxicity.
CELLULAR PHENOTYPES OF GLIOBLASTOMA AND PROGNOSIS OF TUMOR OUTCOME
Authors: Reva Ivan , Yamamoto Tatsuo , Mozhilevskaya Ekaterina , Zinkova Ekaterina , Zolotov Alexander , Soroka Anatoliy , Zhibanov Pavel , Bondar Evgeny , Krasnikov Yuri , Gorbarenko Rodion , Gainulina Julia , Reva Galina
Published: August 2023

In solid malignant tumors, as well as in hematological tumors, cancer stem cells (CSCs), quiescent, pluripotent, self-renewing neoplastic, also known as tumor initiating cells, have been identified. CSC tumors are resistant not only to chemotherapy, but also to radiation therapy, as well as they play their role in the occurrence of relapses after surgical treatment, An unfavorable prognosis due to an aggressive course and complications after treatment of the most common primary brain tumor - glioblastoma multiforme (GBM), is also associated with CSC. One of the mechanisms that affect the physiological regeneration of tissues, but do not work under conditions of malignancy, is the environment and composition of the cellular tumor ensemble, represented by the phenotypes of cellular and adaptive immunity. Using immunohistochemical phenotyping methods, the authors identified immunocytes/phagocytes and established the features of their localization in the malignant tissue and at the border around the tumor. It was concluded that due to apoptosis around the tumor, intercellular signaling and migration of immunocytes/phagocytes to the focus of the tumor process are disrupted. The primary tumor process is not associated with damage to the tissue cambium genome, but with the migration of immature stem cells of the hematogenous pool, capable of proliferating and partially entering into incomplete differentiation under conditions of hypoxia and the absence of blood vessels. At the second stage, connective tissue is formed, which grows into vessels, the wall of which is represented by immature endothelium, with impaired transport function. According to the authors, metastasis of cancer cells does not occur by hematogenous and lymphogenous pathways, but is associated with the development of additional foci of hematopoiesis as a result of the adaptation of the human body to the loss of stem and semi-stem cells, precursors for normal regeneration of the nervous tissue.
AGING RETINAL NEURONS IN RETINOBLASTOMA
Authors: Reva Ivan , Yamamoto Tatsuo , Mozhilevskaya Ekaterina , Zhibanov Pavel , Bondar Evgeni , Gainulina Julia , Islam Shahariar , Reva Galina
Published: August 2023

Cells of non-hereditary retinblastoma in the enucleated eye of a 9-year-old boy were studied using classical histological and immunohistochemical methods. It has been established that disturbances in retinal morphogenesis can be associated with a stop in development at the stage of formation of retinal layers. The inner wall of the eyecup after the eviction of the neuroglia retained proliferative activity in the cells of the outer retinal layer, which lost the ability to differentiate over a larger extent of the retina and migrate to the inner layers. Cells that have differentiated according to the program of neuronal development are located among malignant cells and are characterized by signs of atypical aging with granules of black-brown pigment in the cytoplasm. It has been established that in the lack of angiogenesis these cells in the inner layers of the retina have secretory activity and are immunohistochemically phenotyped as VEGF-positive cells. This indicates cellular and tissue adaptation to malignancy at the terminal stage of retinoblastoma, which grows into the optic nerve and metastasizes to the brain. VEGF-positive cells can serve as one of the key targets in solving the problem of conservative treatment of retinoblastoma diagnosed in the late stages of the disease.
A CASE OF DEVELOPING SQUAMOUS CELL AND BASAL-CELL CARCINOMA IN PATIENTS WITH PSORIASIS
Authors: Efanova Elena , Rusak Yuri , Vasilieva Ekaterina
Published: August 2023

The described clinical example illustrates the rare association of psoriasis with basal cell and squamous cell carcinoma. This clinical case may be of interest to dermatologists and oncologists. It illustrates the neglect of the process in view of the late treatment of the patient. The rising incidence rates of skin cancer are caused by exposure to UVB procedures and increasing with age, which emphasizes the importance of thorough dermatological screening among patients with psoriasis and histological examination of old psoriatic plaques. Alertness for the early detection of skin tumors is relevant not only among medical workers, but also among the population.
LITERATURA DE AUTORIA FEMININA NOS LIVROS DIDÁTICOS DE LÍNGUA PORTUGUESA
Authors: Senna Ferreira Luciane , Ferri Pinto Julia , Pereira de Pinho Pâmela
Published: August 2023

O artigo tem o objetivo de apresentar a pesquisa A literatura de autoria feminina presente nos livros didáticos de língua portuguesa do ensino médio adotados nas escolas públicas no município de Osório/RS, desenvolvida no IFRS - Campus Osório. Partimos da perspectiva de que o livro didático é uma ferramenta complementar/auxiliar à/ao docente nas práticas educacionais, sendo em muitos contextos o único recurso disponível para o trabalho em sala de aula, tanto para professores/as quanto para discentes. Assim, a pesquisa direcionou-se a uma análise quantitativa da presença de literatura de autoria feminina nos livros didáticos adotados no município de Osório/RS. A partir de um recorte da pesquisa maior, apresentamos neste artigo os dados referentes às obras de literatura utilizadas na coletânea Ser Protagonista: Língua Portuguesa (PNLD/2018). Os resultados demonstraram o baixo volume, nas unidades dedicadas à literatura dessa coleção, de obras de autoria feminina, indicando uma desigualdade de gênero na abordagem didática de materiais oficiais direcionados à educação.
POR TRÁS DOS QUADROS BRANCOS E CANETÕES
Authors: Henriques do Amaral Jonathan , Reiziger de Melo Rodrigues Robert , Lazzaretti Motta Bianca , Bendorovicz Trevisan Janine
Published: August 2023

Este artigo teve o objetivo de conhecer os perfis sociodemográfico e profissional dos docentes de Sociologia das escolas estaduais, municipais e particulares dos 25 municípios abrangidos pela 16ª Coordenadoria Regional de Educação do Rio Grande do Sul. Embora essa Coordenadoria seja estadual, serviu como forma de delimitar os municípios participantes do estudo. Para realizar a pesquisa, inicialmente, contataram-se as escolas de ensino médio da região, a fim de verificar se ofertavam Sociologia e, em caso positivo, quem eram os docentes da disciplina e seus contatos. Posteriormente, criou-se um questionário virtual na plataforma Google Forms, contendo 37 questões, a maioria de múltipla escolha. Enviou-se o questionário aos docentes via e-mail ou WhatsApp, conforme o contato informado pelas escolas. Mesmo que o questionário virtual tenha benefícios devido à facilidade da coleta de respostas e à economia de tempo, constataram-se dificuldades em conseguir engajamento dos participantes por meio da internet, uma vez que se obtiveram apenas 13 respostas. Os resultados apontam que a maioria dos docentes atua na rede estadual e leciona em mais de uma escola; além disso, onze lecionam mais de um componente curricular e apenas três são graduados em Sociologia ou Ciências Sociais. Contudo, os demais docentes possuem formação em Ciências Humanas, demonstrando que não há um abismo entre a área de graduação e a área de atuação. Com base nos dados da pesquisa, formular-se-á um curso de extensão para os professores de Sociologia da região.
LSTNETA
Authors: Manfredini Ricardo Augusto
Published: August 2023

Apresentamos um estudo comparativo das previsões de consumo de eletricidade utilizando o método SARIMAX (Seasonal Auto Regressive Moving Average eXogenous variables), o modelo HyFis2 (Hybrid Neural Fuzzy Inference System) e o modelo LSTNetA (Long and Short Time Series Network Adapted), uma rede neural híbrida contendo camadas GRU (Gated Recurrent Unit), CNN (Convolutional Neural Network) e camadas densas, especialmente adaptadas para este estudo de caso. O estudo experimental comparativo desenvolvido mostrou um resultado superior para o modelo LSTNetA com previsões de consumo muito mais próximas do consumo real. O modelo LSTNetA no estudo de caso teve um rmse (root mean squared error ) de 198,44, o modelo HyFis2 602,71 e o método SARIMAX 604,58.
Patenteamento de biotecnologias no Brasil: proteção patentária no campo biotecnológico de angiospermas nativas brasileiras
Authors: Rabelo Kassia Cristina De Caldas , Nunes Rhewter , Rabelo Juliano Caldas , Furquim Maria Gláucia Dourado , Sousa Júnior José Carlos , Telles Mariana Pires de Campos
Published: August 2023

O objetivo deste trabalho foi discutir aspectos do sistema patentário, a partir de um panorama do processo de patenteamento em biotecnologia no Brasil, enfocando espécies vegetais de angiospermas nativas brasileiras. As patentes foram levantadas no portal do Instituto Nacional de Propriedade Industrial (INPI) e classificadas quanto à área de conhecimento, de acordo com a Classificação Internacional de Patentes (IPC-WIPO), por entidades depositantes e por prioridade unionista. Verificou-se a situação legal de cada patente depositada. Recuperaram-se 628 registros de patentes relacionadas à área biotecnológica para 265 espécies de angiospermas. A maior parte dos depósitos de patentes no Brasil referem-se à área de ciências da saúde, cujos principais depositantes são os centros de ensino. Grande parte dos documentos de registros de patentes encontram-se com status de publicadas, em processo de análise, indeferidas ou arquivadas, e que apenas 85 registros estão como patentes concedidas. Os resultados mostram que o Brasil precisa pesquisar e gerar mais processos e produtos inovadores com outras espécies que possam apresentar benefícios e retorno socioeconômicos, considerando-se todo o contexto da bioeconomia. Este trabalho destaca a importância do investimento brasileiro na geração e proteção de tecnologias que envolvem as espécies de angiospermas nativas, quanto ao fortalecimento de parcerias e quanto à capacitação continuada de propriedade intelectual.
O sistema agroalimentar brasileiro e os desafios em CT&I: uma agenda social e econômica
Authors: Pedroso Maria Thereza
Published: August 2023

Este artigo apresenta e analisa diversas facetas centrais que, de forma genérica, identificam o desenvolvimento do capitalismo agrário, as quais estruturaram a transição entre o antigo setor primário e a formação do moderno sistema agroalimentar. Em particular, mostra o papel central da produtividade como canal nevrálgico do processo de transformação. Em adição, aponta as principais características dessa passagem histórica aplicada ao caso brasileiro. O texto introduz breves leituras interpretativas extraídas dos artigos que integram livro recentemente lançado e, em sua seção final, sugere diversos esforços de pesquisa que poderão integrar uma agenda de CT&I, também separados entre os diversos campos disciplinares que integram as Ciências Sociais. Confrontado com as amplas ambições de seus objetivos, o artigo também aponta suas limitações, sugerindo que novas iniciativas podem avançar o conhecimento proposto.
Open Heterogeneous Data for Condition Monitoring of Multi Faults in Rotating Machines Used in Different Operating Conditions
Authors: Soualhi Moncef , Soualhi Abdenour , Nguyen Khanh T. P. , Medjaher Kamal , Guy Clerc , Hubert Razik
Published: August 2023

Rotating machines are widely used in several fields such as railways, renewable energies, robotics, etc. This diversity of application implies a large variety of faults of critical components susceptible to fail. For this purpose, prognostics and health management (PHM) is deployed to effectively monitor these components through the detection, diagnostics as well as prognostics of faults. In the literature, there exist numerous methods to ensure the above monitoring activities. However, few of them consider different failure types using heterogeneous data and various operating conditions. Also, there are no dominant methods that can be generalized for monitoring. For this reason, the genericity of these methods and their applicability in several systems is a crucial issue. To help researchers to achieve the above challenges, this paper presents a detailed description of data sources from experimental test benches. These data-sets correspond to different case studies that monitor the health states of multiple critical components in various operating conditions using numerous sensors.
DETEKSI	DINI	BUTA	WARNA	DENGAN	APLIKASI	ISHISHARA	BERBASIS	IOS DI	SANGGAR	BELAJAR SUNGAI	CHINCHIN GOMBAK, KUALA	LUMPUR	MALAYSIA
Authors: Elise Cindy Febriliana , M. Psi. Setriani , M. Psi. Meilia Ishar
Published: August 2023

Buta warna merupakan suatu kelaianan yang tidak dapat disadari namun deteksi dini tetap diperlukan guna mengenatahui ada tidaknya kelainan ini. buta warna sendiri dapat di identifikasi menjadi dua yakni buta warna total dan buta warna sebagian. Pada penderita buta warna sebagian atau partial akan kesulitan untuk mengenali warna merah, hijau, biru dan kuning namun tetap dapat mengenali warna lainya dengan mudah. Sedangkan pada penderita buta warna total hanya dapat mengenali warna hitam dan putih. Program ini dilakukan sebagai bentuk kepedulian terhadap anak-anak imigran Indonesia yang belajar di salah satu Sanggar Belajar di kuala lumpur-Malaysia sebagai upaya untuk langkah awal penanganan lebih lanjut jika ditemukan anak dengan buta warna total. Hasil dari program ini diketahui bahwa adanya kemungkinan anak menderita buta warna karena semua anaktidak ada yang mendapatkan nilai jawaban benar 100%. Hasil dari tes diharapkan menjadi tes berbasis aplikasi ini tidak dapat di jadikan acuan diagnosa karena masih memerlukan penanganan tenaga ahli yang lengkap. Kata kunci: Buta warna, deteksi dini, aplikasi tes ishishara.
PELATIHAN PENYUSUNAN MATERI AJAR DAN METODE PENGAJARAN BAGI GURU DI PAUD NASYIAH DESA SIDODARI KECAMATAN NATAR KABUPATEN LAMPUNG SELATAN
Authors: Alrajafi Gali , Munir Eryon , Maretha Carla , Wahyuningsih Yulia
Published: August 2023

Pendidikan anak usia dini (PAUD) merupakan gerbang awal generasi muda bangsa Indonesia mendapatkan pengetahuan dan keterampilan kreatif. Dalam perkembangannya PAUD bernilai esensial dalam proses belajar anak. Proses pendidikan yang asyik dan kreatif membuat daya nalar anak terangsang dengan baik. Selain itu keterampilan kognitif, afektif, dan psikomotorik juga diupayakan untuk berkembang dengan pesat. Pembelajaran di PAUD menyentuh konsep-konsep dasar keterampilan tersebut, khususnya yang terkait dengan inteligensia kebahasaan. Oleh karena itu, penting untuk memberikan perhatian khusus pada materi yang diajarkan dan metode penyampaiannya yang dalam hal ini ialah bahasa asing. Sesuai dengan amanah peta jalan pengabdian kepada masyarakat Prodi Sastra Inggris, Universitas Muhammadiyah Lampung memberikan pelatihan kepada guru-guru PAUD Nasyiatul Aisyiha untuk meningkatkan kapabilitas dalam pengajaran bahasa Inggris bagi anak PAUD. Kegiatan ini dilakukan dengan metode partisipatif dalam beberapa tahapan yaitu koordinasi dengan pengurus PAUD, survey lapangan, dan pelaksanaan program. Hasil dan implementasi ialah meningkatkan pengetahuan dan kemampuan pendidik dalam menyusun bahan ajar dan menerapkan metode pengajaran yang efektif bagi peserta didik. Kata kunci: PAUD, Bahan Ajar, Metode Pembelajran, Bahasa Inggris
هيدرولوجية مجرى شط الديــوانية
Authors: الاسدي الأستاذ الدكتور كفاح , جابر الباحثة زينب
Published: August 2023

اتضح من خلال دراسة الخصائص الهيدرولوجية لشط الديوانية، المتمثلة بخصائص التصريف (السنوي، الفصلي، الشهري، ومصادر الغذاء، وحمولة النهر، والخصائص النوعية الفيزيائية منها والكيميائية) للفترة (1987-2011) يختلف مكانيا وزمانيا في منطقة الدراسة بسبب تقلب كمية الهطول من سنة إلى أخرى وموسم آخر فضلا عن عامل تأثير التلميذ على الهدف الإنساني المبني على النهر. عند مقارنة جميع نتائج الفحوصات المخبرية بشط الديوانية مع المحددات المسموح بها لنظام صيانة الانهار من التلوث بالقانون رقم 25 لسنة 1976 وجد أن العكارة والتوصيل الكهربائي والمغنيسيوم والكالسيوم لجميع المواقع خارج الحدود مسموح بها ضمن القانون بينما تتميز بقيم الخواص درجة الحرارة ودرجة الحموضة والصوديوم والكبريتات ضمن الحدود المسموح بها لجميع أشهر مواقع الدراسة.
الجذور الجاهلية لعروض الخليلي
Authors: قبادي الأستاذ المساعد الدكتور  علي , Nori Ali
Published: August 2023

ولا يحتمل أن يكون علم العروض الدقيق شبه الكامل المنسوب إلى خليل بن أحمد، لا أصل له ولا جذر. فاستعان بعلم أسلافه من العرب والعجم في تأسيس هذا العلم. وقد أشار المنظرون في هذه الحالة إلى بعض الأمثلة غير العربية على العروض. وأشار أبو الريحان البيروني إلى الجذور الهندية التي يبدو أن خليل قد استخدمها. كما يعتقد نزار حسن الديراني أنه استخدم عرض سوريانو بشكل أو بآخر. ويؤكد صفاء خلوصي وكمال إبراهيم أن العروض العربية هي تقليد للعروض الأجنبية. ويبدو أن المصادر غير العربية قد حظيت باهتمام المنظرين وأهملت المصادر العربية التي كانت ملحوظة وربما استخدمها خليل. والسؤال هو كيف يمكن أن يكون خليل قد اعتمد في عروضه على العروض الأجنبية فقط دون أي استخدام للمصادر العربية. في هذه القاعدة، إلى جانب المصادر الأجنبية، كانت هناك سوابق ونماذج أولية وأنماط تعود أصولها إلى الثقافة العربية التي استخدمها. ويتجه المؤلفون إلى تحليل مصادر وجذور وأسلاف العروض التي استمدها خليل من التراث الثقافي العربي واستخدمها في عمله.
الأنماط التراثية في شعر أيمن العتوم (ديوان خذنيإلي المسجدالأقصي نموذجًا)
Authors: رساني الأستاذ المساعد الدكتور  عباس
Published: August 2023

في عملية خلق الأعمال الفنية، يولي الشعراء المعاصرون اهتماما خاصا للتراث نظرا لمكانته البارزة. ولذلك فقد انتشرت على نطاق واسع في شعرهم. والسبب هو أن التراث بمثابة جسر بين الماضي والحاضر. تعتبر هذه الدراسة محاولة لتحليل موضوع التراث في شعر الشاعر الأردني المعاصر أيمن العتوم. وإلى جانب تطبيق التراث في متن قصائده، يتناول الشاعر تصوير التحديات الإنسانية وأزمات الحياة المعاصرة والمشاكل التي يواجهها المجتمع الإسلامي والعربي، وخاصة المواضيع التي ترتبط ارتباطا وثيقا بفلسطين. وعليه فإن الدفاع عن الهوية الدينية والوطنية والصراع مع الكيان الصهيوني والتبعية للوطن من أهم دوافع الشاعر لتطبيق التراث في شعره. اعتمدت هذه الدراسة على المنهج الوصفي التحليلي مع التركيز على مصادر الأدب العربي المعاصر لتحليل الموضوع. وأخيراً توصلت الدراسة إلى نتيجة مفادها أن استخدام التراث في شعر الشاعر لم يتم لا شعورياً، بل تم خلقه من خلال وعي ووعي كامل يحاول من خلاله الكشف عن تحديات الإنسان المعاصر من جهة، ومن جهة أخرى. ليضفي على شعره سمات الأصالة والتجذر. أهم مظاهر التراث في شعر أيمن العتوم التراث الديني والتاريخي والأدبي والصوفي
ولاية التشريع للنبي () عند جمهور المسلمين
Authors: فرهود الاستاذ المساعد الدكتور رزاق , كاظم الباحث سلام
Published: August 2023

ومن الواضح أن وظيفة النبي صلى الله عليه وسلم يمكن أن تتسع لتشمل إصدار الأوامر التشريعية التي لم ينشر فيها نص قرآني، وذلك لإدارة الشؤون العامة للأمة. المجتمع وحل الخلافات بين الناس. واختلف علماء الأمة المسلمة في وجوب الاتباع أو عدم الاتباع؛ لأنه دون وحي منزل. ومنهم من رأى وجوب العمل به وأخذه لأنه يؤدي إلى نتيجة من الله. وهم الشافعية والزيدية. ومنهم من رأى في ذلك جهد النبي. الحنابلة، وعندهم ن رأى أن النبي (صلى الله عليه وسلم) عندما ينتظر حدثاً يقصد الحكم. وإذا لم ينزل عليه ثم يستلهم حكم الشرع أو التشريع عندهم الأهناف الإباضي، وهكذا أصبحت الولاية التشريعية للنبي أوضح وأضيق عند جمهور المسلمين وعند فقهاء وأئمة المذاهب الإسلامية، و الحمد لله رب كل شيء
مدح الرسول الأكرم () في الشعر العربي – العهد المملوكي- أنموذجا
Authors: رحيمي الباحث أصغر رحيمي , دلفي الأستاذ المساعد  الدكتور يابر
Published: August 2023

البحث عن الإمامة بحث بمعنى الحساسية والأهمية لأننا نرى أن الإمام يجب أن يعرف، وعندما نبحث عن الإمام ونصب الإمام بعد رسول الله (ص) نريد أن نعرف الحق في ذلك قضية خلافية ثم بعد وفاة النبي (ص) في المدارس الإسلامية أصبحت الإمامة قضية مهمة ورئاسة عامة لجميع المسلمين في العالم لإقامة أحكام الشريعة الإسلامية وحمل الدعوة الإسلامية إلى الإسلام. العالم وإقامة الإمام فرضاً على المسلمين جميعاً في جميع دول العالم والقيام به، مثل فرض الفرائض التي فرضها الله على المسلمين وضرورة عدم تغييرها والتشدد فيها وعدم القيام بها. فإن المعصية من أكبر الكبائر يعذبها الله أشد العذاب وترى الإمامية أن إمام الإمام علي (عليه السلام) مقام الله، ولا يجوز له الدخول فيه لأن الإمام (عليه السلام) (عليه السلام) متطهراً من كل رجس ومؤمناً وعالماً ومدبراً لأمور المسلمين، فيرون الإمامة بعد النبي (صلى الله عليه وسلم) وهذا البحث من خلال المنهج التحليلي يعرض ويدرس البرهان للإمام علي (عليه السلام) من خلال الآيات القرآنية والأحاديث
اثر استخدام برنامج عرض الشرائح الالكترونية على تحصيل طلاب الصف الاول المتوسط في مادة التربية الفنية
Authors: المظفر المدرس الدكتور لقمان
Published: August 2023

عنوان البحث اثر استخدام برنامج عرض الشرائح الالكترونية على تحصيل طلاب المتوسطة في مادة التربية الفنية

وكانت مشكلة البحث السؤال التالي: مااثر استخدام برنامج عرض الشرائح الالكترونية على تحصيل طلاب المتوسطة في مادة التربية الفنية

اما هدف البحث هو التعرف على اثر استخدام برنامج عرض الشرائح الالكترونية على تحصيل طلاب المتوسطة في مادة التربية الفنية

وتوصل الباحث الة النتائج الاتية

لاتوجد فروق ذات دلالة احصائية بين المجموعة التجريبية والضابطة على مقياس عرض الشرائح في القياس البعدي لاختيار صحة هذه الفرضية استخدم اختبار(مان ونتي ) لمعرفة دلالة الفروض بين المجموعة التجريبية والضابطة اذا اظهرت ان القيمة المحسوبة التي تساوي (0,500) وهي دالة احصائيا عند مقارنتها بالقيمة الجدولية والتي تساوي (23) عند مستوى دلالة وهذا يعني رفض الفرضية الصفرية وقبول الفرضية البديلة اي توجد المجموعتين التجريبية والضابطة بعد تطبيق البرنامج لعرض الشرائح ولصالح التجريبية والجدول يوضح القيمة الاحصائية (مان ونتي ) لدى افراد المجموعتين (التجريبية والضابطة ) على قياس عرض الشرائح بعد تطبيق برنامج عرض الشرائح على المجموعة التجريبية
أسرار الإقناع في مناظرات الباقر ()
Authors: عويد المدرس الدكتور أنوار
Published: August 2023

يعد أسلوب الإقناع فناً فطرياً قديماً، إلا أنه لم يبرز كعلم مستقل إلا ضمن نتاجات القرن العشرين، حيث أثبتت الدراسات أن هناك عدة أمور يجب توفرها في شخصية المخاطب حتى يتمكن من تحقيق هذه الطريقة. وفي فحص شخصية الامام الباقر (عليه السلام) من خلال مناظراته تبين أن كلامه مقنع من الدرجة الأولى، معتمدا في تحقيق ذلك على عدة تقنيات منها التقنيات اللغوية والبلاغية وشبه المنطقية فخرجت الدراسة تحت عنوان "أسرار الإقناع في مناظرات الباقر ع". وجاءت الدراسة في مقدمة وفصلين، تناول الفصل الأول تعريف الإقناع والاقتناع والشروط التي يجب توافرها في الطرفين، وتناول الفصل الثاني أساليب الإقناع. ويتضح من الدراسة أن الإمام قد طبق كل هذه التقنيات واستخدم ألفاظه من أجل إقناع المخاطب حسب شخصياته؛ فمنهم من وصل إلى درجة الاقتناع، ومنهم من زاد عناده وعدم رغبته