bluuebunny/crossref_metadata_2025 huggingface dataset:
Anemia hemolítica autoinmune mixta en adulto mayor post infección por sars-cov-2. Reporte de caso
Authors: Lopez Muñoz Diego Fernando , Medina González Manuel Iván , Guagua Cabezas Daniel Felipe , Paredes Polanco Manuel Alejandro
Published: March 2023

Masculino 76 años, antecedente previo de SARS-CoV-2, requirió hospitalización. Ingresa al servicio de urgencias por cuadro clínico caracterizado por dificultad para respirar, dolor abdominal, síntomas urinarios y edema periférico. Signos vitales: Temperatura 38°C, FR 26 rpm, FC 100 lpm, PA 128/63 mmHg, SPO2 85%, FiO2 21%. Exploración Física: consciente y orientado en tiempo, lugar y persona. Exploración física: Palidez cutánea e ictericia en escleras. Abdomen blando, depresible y doloroso a la palpación en ambos cuadrantes superiores y marcada hepatoesplenomegalia. Paraclínicos: hemograma reporta anemia macrocítica, hipercrómica, con recuento bajo de glóbulos rojos, leucopenia y plaquetas normales en cantidad. ESP: reporta policromasia +++, esferocitos ++, células nucleadas rojas 20 en 100 células blancas contadas, aglutinación ++. Prueba de coombs directa positiva 4+.  Hiperbilirrubinemia a expensas de la indirecta y elevación de la LDH y creatinina sérica 2,8 mg/dL, BUN 40 mg/dL. Derivado a UCI con diagnósticos presuntivos de AHAI, IRA. ITU, donde es manejado con corticoides endovenosos y medicamentos inmunomoduladores. Se conoce poco del mimetismo molecular del virus, según referentes bibliográficos utiliza proteínas de membrana celular para entrar al glóbulo en forma de hapteno y generar una respuesta inmune errada.
QUESTIONS OF LITERARY NORM IN THE EPISTOLARY OF AHATANHEL KRYMSKYI AND BORIS GRINCHENKO
Authors: CHEREMSKA Olha
Published: March 2023

This article is devoted to the analysis of the evolution of the linguistic views of A. Krymskyi in the process of his scientific communication with B. Grinchenko, P. Zhytetskyi and I. Franko (late XIX – early XX centuries). Different contradictory moments in the scientific researches of linguists from the different regions of Ukraine during the period of formation of the Ukrainian literary language were revealed. Various issues of linguistic discussions during the late XIX – early XX centuries, in which prominent linguists from Galicia and Upper Dnieper Ukraine participated, are characterized.
In this context, the most interesting in terms of coverage of various linguistic problems was the correspondence of A. Krymskyi with B. Grinchenko, which lasted for seventeen years (1891–1908). The attitude of scholars to the formation of the criteria of literary word usage and principles of language formation is clarified. It was found out that the main criteria for correct word usage for linguists of Upper Dnieper Ukraine was the presence of a word in the vernacular language and in literary texts, which is confirmed by the materials of the first academic Russian-Ukrainian dictionary edited by A. Krymskyi (1924–1933) and the Dictionary of Ukrainian language compiled by B. Grinchenko (1907–1909). The scientific value of different linguistic ideas expressed by these scholars in their epistolary, especially on the usage of individual words and grammatical forms, as well as the ways of development of Ukrainian literary language, was noted. Their views on formation of the single version of literary language based on the language use of Upper Dnieper Ukraine are outlined. The desire of these linguists to promote the unification of the norms of the Ukrainian language through the creation of grammatical and lexicographical works is characterized.
Based on the analysis of epistolary texts by A. Krymskyi and B. Grinchenko, it is stated out that their ideas contributed to the emergence of valuable grammatical and lexicographical works that contain huge lexical and phraseological material from the Ukrainian classical literature and folklore sources. The fruitful scientific and literary work of these scholars became an integral component of the process of development and unification of literary norms of Ukrainian language.
THE PERSONALITY OF FIELDWORK RESEARCHER IN “BEIRUT STORIES” BY AHATANHEL KRYMSKYI
Authors: HRYMYCH Maryna
Published: March 2023

The article deals with the personality of A. Krymskyi as a fieldwork researcher from the perspective of his fiction book Beirut Stories. The author’s presence in the text is shown not only through the personage of an eccentric muscovite who came to Lebanon to study Arabic, but also through the massive anthropological narrative, which often overshades a plot and personages. The reader can’t get rid the feeling that this narrative is, as a matter of fact, a main hero of the book. It is based on the A. Krymskyi’s experience as a fieldworker who used in his research investigations mainly a method of included observation. The article focuses on the author ‘s usage of onomastic arsenal with the help of which he denotes different identities of Lebanese society through the lenses of anthropology of religion. He works with the official and folk terms: Orthodox, Rums (in the meaning of Orthodox), Greeks (in the same meaning). By the way, the term Greek in the oral speech of Beirut people in the end of 19th century marked also Russians who lived there, and even Orthodox French nuns come from Marseille. Russian expats were also named as Moskobs, Muscovites. Catholics of Beirut were called as Jesuits (in case they are the teachers of the Catholic schools), Franjie, etc. A. Krymskyi as a thoughtful observer noticed that the identity in the Lebanese society of that historical period is situational: depending on context the person could identify him or herself according to the religious, local, social or ethnic identity. The street life in Beirut demonstrates an example of interreligious and interethnic communication and everyday diplomacy, and Ahatanhel Krymskyi methodically incorporated his own observations, communicational experience, oral dialect, folklore to his Beirut Stories.
Electronic and Topological Properties of UIO66-ILs Interaction through a Computational Study
Authors: Nor Ain Fathihah Abdullah  , Lim Jun Wei  , Khairulazhar Jumbri
Published: March 2023

A high surface area adsorbent, such as MOFs, is an attractive option to evacuate heavy metals from wastewater. However, due to the possibility of the MOF structure collapsing when exposed to water, the stability and selectivity of MOFs for wastewater treatment remain a debatable task. Depending on the application, it has been shown that the consolidation of IL into MOF could improve the stability and reusability of pure MOF; nevertheless, research on the molecular interactions between the MOF framework and IL is still lacking. The stability, compatibility, and selectivity of this hybrid material are significantly influenced by the fundamental interactions between the MOFs and ILs moieties (cation and anion molecules), particularly the sorts of interactions. In this work, we focused on the topological properties of ILs and utilization of molecular docking calculations to assess the binding energy (ΔGbind) and binding affinity between UIO66 with TFSI-imidazole and TFSI-pyridinium ILs studied. The properties of ILs such as aromaticity of the structures, bond critical point (BCP), and electrostatic potential map surface were carried out using the Gaussian and Multiwfn software while the binding energies were computed using the AutoDock software to identify particular binding sites for IL toward MOF. The Autodock software's default setting was used to prepare all of the structures. To determine the binding locations of MOF, the IL was successively incorporated into the MOF pores inside the grid box of 90 x 90 x 90 Å (x, y, and z) dimensions. The results showed that both ILs; TFSI-imidazole, and TFSI-pyridinium IL, interacted favorably with the MOFs, having binding energies varying from -4.12 to -8.60 kcal mol-1. The stability of UIO66-ILs system increases with the addition of anion and cation. According to docking molecular structures, both cation and anion tend to bind in the corner of the MOF pore, which is in line with the previous work.
GOOGLE EARTH ENGINE FOR LANDSAT IMAGE PROCESSING AND ASSESSING LULC CLASSIFICATION IN SOUTHWESTERN CÔTE D’IVOIRE
Authors: Kouassi Christian Jonathan Anoma , Qian Chen , Khan Dilawar , Achille Lutumba Suika , Kebin Zhang , Omifolaji James Kehinde , Yang Xiaohui
Published: March 2023

High-accuracy land use and land cover maps (LULC) are increasingly in demand for environmental management and decision-making. Despite the limitation, Machine learning classifiers (MLC) fill the gap in any complex issue related to LULC data accuracy. Visualizing land-cover information is critical in mitigating Côte d’Ivoire’s deforestation and land use planning using the Google Earth Engine (GEE) software. This paper estimates the probability of RF classification in South Western Côte d’Ivoire. Landsat 8 Surface Reflectance Tiers 1 (L8OLI/TIRS) data with a resolution of 30 mn for 2020 were used to classify the western and southwestern Forest areas of Côte d’Ivoire. The Random Forest (RF) learning classifier was calibrated using 80% training data and 20% testing data to assess GEE classification accuracy performance. The findings indicate that the Forest land class accounts for 39.48% of the entire study area, followed by the Bareland class, the Cultivated land class 21.28±0.90%, the Water class 1.94±0.27%, and the 0.96±0.60% Urban class respectively. The classification reliability test results show that 99.85%±1.95 is the overall training accuracy (OTA), and 99.81±1.95% for the training kappa (TK). The overall validation accuracy (VOA) is 94.02±1.90%, while 92.25±1.88% validation kappa (VK) and 92.45±1.88% RF Accuracy. The different coefficients classification accuracy results obtained from the RF confusion matrix indicate that each class has three good performances. This is due to the cultivated land samples lower spatial resolution and smaller sample numbers, resulting in a lower PA for this class than for the other classes. All had producer accuracy (PA) and user accuracy (UA) more than 90% using the L8OLI/TIRS data. Using the RF-based classification method integrated into the GEE provides an efficient and high scores accuracy for classifying land use and land cover in the study area.
First Observation of Chromospheric Waves in a Sunspot by DKIST/ViSP: The Anatomy of an Umbral Flash
Authors: French Ryan J. , Bogdan Thomas J. , Casini Roberto , de Wijn Alfred G. , Judge Philip G.
Published: March 2023

The Visible Spectro-Polarimeter of the NSF Daniel K. Inouye Solar Telescope collected its Science Verification data on 2021 May 7–8. The instrument observed multiple layers of a sunspot atmosphere simultaneously, in passbands of Ca ii 397 nm (H line), Fe i 630 nm, and Ca ii 854 nm, scanning the region with a spatial sampling of 0.″041 and an average temporal cadence of 7.76 s, for a duration of 38.8 minutes. The slit moved southward across the plane of sky at 3.83 km s−1. The spectropolarimetric scans exhibit prominent oscillatory “ridge” structures that lie nearly perpendicular to the direction of slit motion (north to south). These ridges are visible in the maps of line intensity, central wavelength, line width, and both linear and circular polarization. Contemporaneous Atmospheric Imaging Assembly observations indicate that these ridges are purely temporal in character and are likely attributed to the familiar chromospheric 3 minute umbral oscillations. We observe in detail a steady umbral flash near the center of the sunspot umbra. Although bad seeing limited the spatial resolution, the unique high signal-to-noise ratio data enable us to estimate the shock Mach numbers (≈2), propagation speeds (≈9 km s−1), and their impacts on the longitudinal magnetic field (ΔB ≈ 50 G), gas pressure, and temperature (ΔT/T ≈ 0.1) of subshocks over 30 s. We also find evidence for rarefaction waves situated between neighboring wave train shocks. The Ca ii 854 nm line width is fairly steady throughout the umbral flash, except for a sharp 1.5 km s−1 dip immediately before, and a comparable spike immediately after, the passage of the shock front. This zigzag in line width is centered on the subshock and extends over 0.″4.
Gravitational Wave Source Populations: Disentangling an AGN Component
Authors: Gayathri V. , Wysocki Daniel , Yang Y. , Delfavero Vera , O’Shaughnessy R. , Haiman Z. , Tagawa H. , Bartos I.
Published: March 2023

The astrophysical origin of over 90 compact binary mergers discovered by the LIGO and Virgo gravitational wave observatories is an open question. While the unusual mass and spin of some of the discovered objects constrain progenitor scenarios, the observed mergers are consistent with multiple interpretations. A promising approach to solve this question is to consider the observed distributions of binary properties and compare them to expectations from different origin scenarios. Here we describe a new hierarchical population analysis framework to assess the relative contribution of different formation channels simultaneously. For this study we considered binary formation in active galactic nucleus (AGN) disks along with phenomenological models, but the same framework can be extended to other models. We find that high-mass and high-mass-ratio binaries appear more likely to have an AGN origin compared to having the same origin as lower-mass events. Future observations of high-mass black hole mergers could further disentangle the AGN component from other channels.
South American terrestrial Gastropoda in the collection of the Auckland War Memorial Museum
Authors: Salvador Rodrigo B. , Breure Abraham S. H. , Hannam Severine , Blom Wilma M.
Published: March 2023

The catalogued collection of South American terrestrial gastropods, including the Caribbean ABC islands and Trinidad & Tobago, of the Auckland War Memorial Museum (AM), New Zealand, is discussed here. In total, 264 specimen lots from South America were found in the AM collection, including eight type lots. Twelve of the specimens represent new geographic distribution data, including the first known precise locality for the species Bostryx luridus (L. Pfeiffer, 1863) and potentially for Drymaeus cf. waldoschmidti Parodiz, 1962 as well. The specimens of Lopesianus crenulatus Weyrauch, 1967 allowed for the revision of the monospecific genus Lopesianus Weyrauch, 1958, which is herein considered valid in the family Simpulopsidae.
Research on measurement and disequilibrium of manufacturing digital transformation: Based on the text mining data of A-share listed companies
Authors: Li Chong , Long Guoqiong , Li Shuai
Published: March 2023

Quantitative analysis of digital transformation is an important part of relevant research in the digital field. Based on the annual report data of China's manufacturing listed companies from 2011 to 2019, this study applies cloud computing to the mining and analysis of text data, and uses the Term Frequency-Inverse Document Frequency method under machine learning to measure the digital transformation index value of manufacturing enterprises. The results show that: (1) On the whole, the current pace of digital transformation of manufacturing enterprises continues to accelerate, and the digital transformation of manufacturing has gradually spread from the eastern coastal areas to the central and western inland areas. (2) In horizontal comparison, among the five types of "ABCDE" digital modules constructed, artificial intelligence develops the fastest, cloud computing index value is second, and block chain value is the smallest. In vertical comparison, the leading provinces such as Beijing, Guangdong, and Shanghai have certain stability and a solid leading position, and there are occasional highlights in the central and western provinces. (3) In terms of polarization distribution, the digitalization of the manufacturing industry has obvious multi-peak patterns, showing the phenomenon of multi-polarization of digital services. The eastern region has both aggregate advantages and equilibrium disadvantages. (4) In terms of industry differences, the level of digital transformation in the high-end manufacturing industry is significantly higher than that in the mid-end and low-end industries. On the ownership attributes of enterprise digital transformation, private enterprises are the highest, followed by foreign-funded enterprises, and state-owned enterprises are the lowest. This research provides theoretical enlightenment and factual reference for manufacturing enterprises to carry out digital activities.
Constrained Conditional Moment Restriction Models
Authors: Chernozhukov Victor , Newey Whitney K. , Santos Andres
Published: March 2023

Shape restrictions have played a central role in economics as both testable implications of theory and sufficient conditions for obtaining informative counterfactual predictions. In this paper, we provide a general procedure for inference under shape restrictions in identified and partially identified models defined by conditional moment restrictions. Our test statistics and proposed inference methods are based on the minimum of the generalized method of moments (GMM) objective function with and without shape restrictions. Uniformly valid critical values are obtained through a bootstrap procedure that approximates a subset of the true local parameter space. In an empirical analysis of the effect of childbearing on female labor supply, we show that employing shape restrictions in linear instrumental variables (IV) models can lead to shorter confidence regions for both local and average treatment effects. Other applications we discuss include inference for the variability of quantile IV treatment effects and for bounds on average equivalent variation in a demand model with general heterogeneity.
Connecting to Power: Political Connections, Innovation, and Firm Dynamics
Authors: Akcigit Ufuk , Baslandze Salomé , Lotti Francesca
Published: March 2023

How do political connections affect firm dynamics, innovation, and creative destruction? We extend a Schumpeterian growth model with political connections that help firms ease bureaucratic and regulatory burden. The model highlights how political connections influence an economy's business dynamism and innovation, and generates a number of implications guiding our empirical analysis. We construct a new large‐scale data set for the period 1993–2014, on the universe of firms, workers, and politicians, complemented with corporate financial statements, patent data, and election data, so as to define connected firms as those employing local politicians. We identify a leadership paradox: market leaders are much more likely to be politically connected, but much less likely to innovate. Political connections relate to a higher rate of survival, as well as growth in employment and revenues, but not in productivity—a result that we also confirm using the regression discontinuity design. At the aggregate level, gains from political connections do not offset losses stemming from lower reallocation and growth.
Partir : mobilités résidentielles et conditions de logement en France pendant l’épidémie de Covid-19
Authors: Le Roux Guillaume , Lambert Anne , Bonvalet Catherine , Baril Élodie , Bringé Arnaud , Bajos Nathalie
Published: March 2023

Au printemps 2020, un confinement national a été décrété en France pour lutter contre l’épidémie de Covid-19 – le plus long et le plus strict jusqu’à ce jour. Celui-ci a entraîné des mouvements spontanés de populations, largement médiatisés autour de la figure de l’exode urbain des Parisiens. Mais les départs des grandes villes vers les campagnes ont-ils été les seuls types de mobilité pendant cette période ? Et que nous apprennent en retour les mobilités de confinement sur les pratiques résidentielles et conditions de logement ordinaires des ménages, ainsi que sur les ressources mobilisées pour faire face à ces situations exceptionnelles ? À partir de l’enquête EpiCOV (Inserm-Drees) conduite en France auprès d’un échantillon de 135 000 personnes de 15 ans et plus à la fin du premier confinement, cet article analyse les différents types de mobilités résidentielles sur le territoire français au printemps 2020. Sans pouvoir présager du caractère durable ou non de ces mobilités, ni de leur répétition au cours des différentes phases de confinement, l’analyse souligne l’hétérogénéité des pratiques de mobilités, saisies ici en termes de distance parcourue, d’évolutions de gradient d’espace urbain, de type et conditions de logement, ainsi que la variété des ressources mobilisées selon le sexe, l’âge et la position sociale des individus. Si les mobilités de longue distance concernent plus souvent des populations aisées, les déplacements de proximité sont quasiment aussi fréquents et concernent des fractions plus hétérogènes de la population.
Projet musical, artistique et linguistique pour élèves allophones en France
Authors: Huet Maïa , Jaubert Alexandre , Olivaux Gabriel , Pagliarin Jérémy
Published: March 2023

L’articolo descrive la realizzazione di un progetto musicale che quattro studenti musicisti del primo anno della Scuola Superiore di Musica di Borgogna-Franca Contea hanno realizzato da gennaio a marzo 2019 nella classe UPE2A del gruppo scolastico Darcy-Mauchaussée a Digione. Questo progetto, elaborato in concertazione con l’insegnante, si iscrive in un progetto pedagogico più ampio di familiarizzazione con l’apprendimento della lingua, pur restando uno strumento di socializzazione. Nel progetto viene sollecitata la creatività dei bambini. L’articolo fa eco qui a quello di G. Vernetto, Le Kamishibaï ou théâtre d’images, ESP n. 44 (giugno 2018).
La nouvelle norme nationale dans le supérieur en Chine : jusqu’où ira l’enseignement du français de spécialité ?
Authors: Zonghong Zhao
Published: March 2023

Nel 2018 è stata pubblicata in Cina una nuova normativa per standardizzare l’insegnamento universitario. Preconizzando uno spirito innovatore, essa annuncia un cambiamento d’orizzonte nei confronti della tradizione educativa cinese. L’autrice riflette sugli effetti di questa normativa nell’insegnamento del francese di specialità, combattuto fra il metodo tradizionale e l’innovazione. L’autrice espone le possibilità di applicare la nuova normativa per migliorare la qualità dell’insegnamento, mettendo in guardia contro il pericolo di un abbandono del metodo tradizionale (col rischio di buttare il bambino con l’acqua sporca).
Langue de l’État et langues des familles, toujours le même débat ?
Authors: Deprez Christine
Published: March 2023

La famiglia è l’istituzione in cui si sviluppano i primi apprendimenti della socializzazione e del linguaggio, in associazione e in interazione con la scuola, la comunità, lo Stato, strutture di socializzazione più ampie della famiglia, con le quali essa entra in contatto e a volte in dissonanza.
Summing up the Feynman diagrams: Toward quantum gluonodynamics
Authors: Arneth Borros
Published: March 2023

Summing up all Feynman diagrams describing an elementary particle can provide a measure of the energy and, with it, the mass of that particle. Moreover, a single mass quantum can be used to convert the Feynman sum into the particle mass. In the following, a mass formula
for the calculation of the baryon and meson masses is introduced and explained. This formula involves calculating the number of possible Feynman diagrams and multiplying it by an elementary mass quantum. The mass formula results from a generalization of the connection between the electromagnetic
coupling constant alpha (Sommerfelds constant) and the Rydberg constant. This mass formula adds an energy parametrization to the standard model, an important component that has been missing to date. Afterward, this mass formula is interpreted, leading to an interpretation of
the elementary particles that is similar to the way in which molecules are interpreted. In this interpretation, gluons take the place of electrons in the case of elementary particles.
Time has no dimensionality or physical existence
Authors: Percival J. N.
Published: March 2023

The author had been focusing on various treatments of time in physics for decades. The author felt that there were major shortcomings in the treatment of time in relativity and even in Newtonian physics. Then the author took a very pragmatic look at how time was actually treated in
GPS to achieve a high precision, real world, working, physics system. The author thought that the actual GPS approach might yield a pragmatic time construct for physics. GPS does NOT use special relativity’s construct of time—but rather an observer independent construct as detailed
below. The author put “Philosophical Time” musings aside and focused solely on finding the right physics construct for time. Finding that proper time was all that physics required, it dawned on the author, quite to his surprise, that proper time also met all the needs of philosophical
time. Furthermore, an even deeper physics insight was that “proper time” is simply a measure of a stable physical process’ cycles. Hence, “time” as a separate physical entity disappeared to be replaced by physical processes each with its own idiosyncratic length/duration,
all of which can be related to each other. These cyclic and noncyclic processes are all driven by known physical forces and energy sources. The properties of time, except for dimensionality, are actually just properties of each individual process that unfolds within 3D space and time is an
emergent, human, generalization of process lengths.
Exploring English Teacher Professional Identity in the University Context
Authors: Herreño-Contreras Yomaira Angélica , Salamanca González Fredy Orlando
Published: March 2023

Identity is a topic that leads towards many paths, people perform many identities depending on the roles or contexts in which they are involved. In this research study, the teachers' identity in a group of English teachers in a private university in Colombia was analyzed . For the data collection process three instruments were applied: a survey, a journal, and an interview. These instruments revealed that teachers see themselves as agents of social change; they feel identified with some iconic representations; teachers' perspectives about their role have been changing over time and there are some imaginary places that for them are ideal for teaching. The participants of this research come from many places, they have distinctive teaching experiences and relate to different backgrounds, nevertheless, all of them believe that their work transcends English teaching as they can be a life example and make their students construct a better society.
To Identify Stress in the Services Sector
Authors: Sharma Deepa
Published: March 2023

Stress is one of the important aspects in the present time. Employee stress is a huge issue not only in the service sector but in every business sector, and it affects both employers and employees in every way. It affects business results due to employee and employer stress despite the fact that reducing pressure in the workplace is detrimental to both parties. Measuring how much work stress is in the service sector and to what extent work stress affects employees and employers is a very difficult task. Because employer stress is different from employee stress from positions, the main objective of this study is to examine how various stressors affect employees and employers in the service sector. Along with those important factors, the main factors of work stress are various negative effects including high complexity of occupations, unfair perception of delegates, long working hours, lack of significant time with family, responsibilities of raising family, bad working environments, and lack of jobs.
Nature-Inspired Algorithms for Energy Management Systems
Authors: Meera P. S.  , Lavanya V.
Published: March 2023

The electric grid is being increasingly integrated with renewable energy sources whose output is mostly fluctuating in nature. The load demand is also increasing day by day, mainly due to the increased interest in electric vehicles and other automated devices. An energy management system helps in maintaining the balance between the available generation and the load demand and thus optimizes the energy usage. It also helps in reducing the peak load, green-house gas emissions, and the operational cost. Energy management can be performed at different levels and is essential for realizing smart homes, smart buildings, and even smart grid. The different objectives considered for designing energy management systems are reduction of emissions, energy cost, operational cost, peak demand, etc. Many traditional and hybrid nature-inspired algorithms are used for optimizing these various objectives. This paper intends to give an overview about the various nature-inspired algorithms used for optimizing energy management systems in homes, buildings, and micro grid.
Fumarate Hydratase-deficient Renal Cell Carcinoma
Authors: Huang Yi-Hsuan , Chow Nan-Haw , Yu Yu-Ting , Su Wen-Pin
Published: March 2023

Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare but aggressive subtype of renal cancer associated with germline or somatic mutations of the FH gene. The histology demonstrates a broad range of morphologic patterns with loss of FH immunostaining. There is no standard therapy approved for FH-deficient RCC, and treatment is often extrapolated from other subtypes of RCC. With a better understanding of the molecular mechanism and pathogenesis, more studies including this population are ongoing. We reported a 33-year-old man with no relevant family history diagnosed with locally advanced FH-deficient RCC and who later developed distant metastasis. He received erlotinib-bevacizumab combination therapy and achieved a partial response. We also performed a literature review of FH-deficient RCC.
Role of Wnt Ligand Secretion Mediator Signaling in Cancer Development
Authors: Chuang Kai-Ting , Wang Li-Ting , Hsu Shih-Hsien
Published: March 2023

Objective:

The Wnt signaling pathway is among the crucial cascades that regulate development and homeostasis of tissue.

Data Sources:

Further, it is closely associated with different types of cancer, which includes glioma, breast, colorectal, lung, and prostate cancer, and hepatocellular carcinoma (HCC). The deviant activation or inhibition of Wnt signaling regulates cancer progression, thereby exerting oncogenic or tumorsuppressive effects that control the invasion, metastasis, and metabolism of cancer cell.

Study Selection:

In the Wnt secretory pathway, lipidmodified Wnt molecules interact with Wnt ligand secretion mediator (WLS), a Wnt cargo receptor. Moreover, they are directed to the plasma membrane and then secreted.

Results:

Loss of WLS function leads to the accumulation of Wnt in the endoplasmic reticulum (ER), leading to retrograde Golgi–ER transport and ER stress associated with the pathogenesis of several conditions, including early embryonic death, and developmental defects related to lymphopoiesis, neurogenesis, and osteogenesis in adults. Although there is substantial evidence, the regulatory mechanisms through which WLS controls cellular functions are not fully elucidated.

Conclusion:

Therefore, the current study aimed to identify the underlying mechanism of the effects of WLS on the development of human diseases.
Antibacterial impact of nonthermal atmospheric plasma on catheter-based biofilms of Staphylococcus epidermidis and Klebsiella pneumoniae isolated from small ruminants in vivo
Authors: Syame Sohier M. , Lotfy Khaled , Abdel-Razik Ahmed M. , Elgabry Elgabry Abd-Elalim , Abouelhag Hussien A. , Fouad Ehab A. , Hakim Ashraf S.
Published: March 2023

Background

Nonthermal atmospheric pressure sterilization is one of the suggested and efficient techniques to hinder the spread of illnesses. Reactive species such as oxygen, hydroxyl, and other radicals play a prime role in the mechanism of plasma sterilization. Staphylococcus epidermidis is the most prevalent cause of primary bacteremia and infections of indwelling medical instruments. The ability to induce disease is related to its natural niche on the skin and capability to adhere and form a biofilm on foreign surfaces. Klebsiella pneumoniae is a zoonotic pathogen frequently isolated from infections related to the presence of bacterial biofilm on devices, such as catheters, which are responsible for loss of patients’ health.

Objective

S. epidermidis and K. pneumoniae are being combated due to their high frequency of occurrence and ability to form biofilms as survival and virulence characteristics. These particular benefits impose a significant financial burden on hospitals.

Materials and methods

In this study, the nonthermal plasma treatment induced by surface dielectric-barrier discharge was used to destruct the developed biofilm formed by clinical S. epidermidis and K. pneumoniae isolated from clinical cases of small ruminants. The biofilms were induced in vivo by catheter-based rat model preparation. The biofilms were examined before and after the treatment using a scanning electron microscope.

Results and conclusion

The produced nonthermal plasma degenerated and reduced the number of adherent and aggregated viable bacteria.
Remarkable improvement of levansucrase production from a newly isolated Aspergillus niger MK788296 strain using agro-industrial wastes through statistical optimization techniques
Authors: Elzairy Nermeen H. , Mostafa Faten A. , Wahab Walaa A. Abdel , Abdel-Naby Mohamed A. , Ragab Yasser M. , Hashem Abdelgawad M.
Published: March 2023

Background and objective

Microbial levansucrase (LS) is a good source for the production of biologically active fructo-oligosaccharides and levan, which have diverse applications in pharmaceutical industries. Therefore, recent studies have focused on the enhancement of LS production through searching for potent microbial producers and optimization of the fermentation conditions. The present study aimed to use agro-industrial waste as a cost-effective carbon source for LS production and maximize the enzyme yield by optimization of the cultural conditions.

Materials and methods

A potent fungal producer of LS was isolated from an Egyptian soil sample that was collected from Giza Governorate at a depth of 5 cm and identified based on internal transcribed spacer identification and then submitted to the gene bank database. The production of LS by the isolated strain was optimized by evaluating the best fermentation state and agro-industrial waste to be used in the fermentation process. After that, further optimization of culture medium composition was established by two statistical designs: the Plackett–Burman design followed by central composite design.

Results and conclusion

The isolated strain was identified asAspergillus nigerMK788296. The first optimization approach declared that using the submerged fermentation technique and utilizing potato peels as the main carbon source led to a 2.4-fold increase in LS production. The statistical optimization resulted in a massive LS production (18870.3 U/ml) with a 59.4-fold increase in enzyme yield than the nonoptimized culture conditions.
Detection and molecular characterization of lipase-producing bacteria
Authors: Alhebshi Alawiah , Al-Sayied Fadwa S. , El-Hamshary Ola I.M.
Published: March 2023

Background

Lipase is a type of hydrolytic enzyme that has several applications and industrial efforts. Lipases are used as biological catalysts to manufacture products such as food ingredients and applied in making fine chemicals. The type of lipase produced from microbes, mainly from bacteria and fungi, represents the most widely used class of enzymes in biotechnological applications and organic chemistry. Microbial enzymes are also more stable than their corresponding plant and animal enzymes, and their production is more convenient and safer, which makes them more important in commercial uses. The oily environment of vegetable oil-processing factories, industrial wastes, soil contaminated with oil, and diesel fuel-polluted soil provides a suitable habitat for lipase-producing microorganisms.

Objective

This study aims to detect new strains of lipase-producing bacteria from diverse sources and different areas in Jeddah, Saudi Arabia. Furthermore, the detected bacterial strains have been identified based on morphological, biochemical, and molecular characterization. The plasmid profile of some isolated bacterial strains has been detected.

Materials and methods

A total of 36 soil samples contaminated with fuel and engine oil were collected from different areas in Jeddah, Saudi Arabia. Tween 20 medium was used to detect the lipolytic activity of the bacterial strains. The isolated bacteria in this study were identified by morphological and biochemical tests and 16SrRNA.

Results and discussion

Results showed that 53 isolates were positive and able to produce lipase, and 15 isolates have been selected as strong lipase-producing bacteria. The sequences were submitted to the NCBI GenBank under accession numbers, accession numbers, ON360988.1 for Acinetobacter sp.
(FS5), ON360990.1 for Alcaligenes faecalis
(FS8), ON360991.1 for Acinetobacter baumannii
(FS9), ON360992.1 for Bacillus tropicus (FS10), ON360993.1 for A. baumannii
(FS11), ON360994.1 for Sphingomonas aeria
(FS15), and ON360996.1 for A. baumannii
(FS17). Plasmids were isolated from selected strains that showed lipase production using a plasmid-isolation miniprep. Results indicated that isolates FS6 and FS15 have no plasmids, whereas FS8 has one plasmid (≈1295.5 bp). Furthermore, isolates FS10 and FS11 have two plasmids (≈1539.3 and 1295.5 bp). In addition, isolate FS9 has three plasmids (≈1539.3, 1295.5, and 417.7 bp). The isolates showed strong lipase activity and could be good sources for the production of lipase.
A Correlational Study to Assess the Level of Perception and Exercise Barriers among People with Type 2 Diabetes Mellitus
Authors: Sarika M. L. , Chakraborty Srijita , Panda Payel
Published: March 2023

Introduction:

The burden of diabetes mellitus (DM) is gradually increasing globally and in developing countries like India. According to the International Diabetes Federation 2019 report, around 77 million people in India are diagnosed with diabetes with a projected increase to 34 million by 2045. Appropriate implementation and practice of lifestyle measures like exercise plays a key role as a supporting factor in effective diabetes management. The main objective of the study was to determine the relation between the exercise barriers and level of disease perception on the disease among people with diabetes.

Methodology:

This is a correlational descriptive study conducted among patients with type 2 DM (T2DM), who are attendees of the medicine outpatient department of a tertiary care hospital in Bhubaneswar. The samples were selected through purposive sampling technique. A self-structured sociodemographic profile, Standardized Appraisal of Diabetes Scale, and Personal Diabetes Questionnaire were used to collect data from the participants.

Results:

The results showed that male (77 [60.2%] among the 128) patients are more susceptible to DM than the females. Majority of the study cohort had a negative appraisal on the DM with a mean value of 17.98 (standard deviation [SD] =1.29). While considering the exercise barriers, the majority of the patients had more exercise barriers with a high mean of 36.77 (SD = 1.04). Here, the correlation between the exercise barrier and level of perception shows a nonsignificant weak negative correlation. The cohort reported that their nonsupportive family and friends are the major exercise barriers with a mean value of 6.

Conclusion:

Exercise, together with medical nutrition therapy, forms the cornerstone of diabetes therapy. The study results identified a lot of barriers among patients with diabetes that hinders exercise in daily life, and it had a significant association with the diabetes control.
Demystifying the Progression of Retinopathy with Glucagon-Like Peptide-1 Receptor Agonists
Authors: Kesavadev Jothydev , Unnikrishnan A. G. , Sanyal Debmalya , Aneja Pankaj , Saboo Banshi D.
Published: March 2023

There have been recent publications indicating the association between diabetic retinopathy (DR) and glucagon-like peptide receptor agonists (GLP-1RAs) raising the concern regarding the use of GLP-1RAs in patients with type-2 diabetes mellitus. After a thorough critical appraisal of those publications, it seems that the evidence generated has certain caveats which led to misinterpretation of the results. In this article, we aim to demystify the myths and bring out the facts in line with the totality of the evidence between the use of GLP-1Ras and DR.
Apneic anesthesia with THRIVE for pediatric bronchial foreign body removal
Authors: Harde Minal J. , Kamble Trupti , Ramchandani Pooja
Published: March 2023

Anesthesia for impacted tracheobronchial foreign body (FB) removal in pediatrics is challenging owing to shared airway, need of tubeless apneic anesthesia, and higher risk of airway complications. Transnasal humidified rapid insufflation ventilatory exchange (THRIVE) has unique applications for apneic anesthesia. The authors describe two pediatric cases of impacted lower bronchial FB that were difficult to retrieve and required long procedure time. They were done successfully under apneic anesthesia using THRIVE that provided intermittent total apnea of 58 and 62 min, respectively, with single-continuous apnea time of 13–18 min. THRIVE facilitated the procedure by providing a safe long apnea time without desaturation and with permissible increase in PaCo2 while maintaining hemodynamic parameters and oxygenation.
Case series on use of intrathecal morphine in pediatric thoracic spine surgeries
Authors: Singh Ranju , Yadav Ayushi , Varshney Preeti G.
Published: March 2023

Intrathecal morphine is a very good analgesic agent and was used frequently in the past. Its use has decreased over the years due to side effects such as respiratory depression, nausea, vomiting, pruritis, and so on. Also, with the introduction of drugs like clonidine and the availability of ultrasonography for regional blocks, the role of morphine has declined. Yet, there are surgeries where intrathecal morphine supersedes all other analgesic modalities to provide excellent intraoperative and postoperative analgesia.
Efficacy and safety of oral tizanidine premedication as pre-emptive analgesia in adult patients undergoing elective surgeries- A systematic review
Authors: Nair Abhijit , Rangaiah Manamohan , Borkar Nitin
Published: March 2023

Tizanidine is a centrally acting α2 agonist which has been used as a premedication due to its opioid-sparing and sympatholytic properties. This systematic review assessed the safety and feasibility of oral tizanidine. After registering the protocol with PROSPERO (CRD42022368546), randomized controlled trials and non-randomized observational studies were searched in various databases. The primary outcome was intraoperative opioid use; the secondary outcomes were 24-hr opioid consumption, pain scores, time to rescue analgesia, and adverse events. The risk of bias scale was used to assess the quality of evidence. Out of 202 studies identified, five studies fulfilled the inclusion criteria. Intraoperative opioid consumption was significantly less in the tizanidine group (MD: -2.40; 95% CI: -4.22, -0.59; P = 0.010; I2 = 0 %). The 24-hr opioid consumption was comparable between both groups (MD: -42.53, 95% CI: -91.45, 6.39; P = 0.09; I2 = 99%). Time to rescue analgesia was comparable between both groups (MD: 308.22; 95% CI: -263.67, 880.11, P = 0.29, I2 = 100%). Pain scores at 6 and 12 hours were comparable (MD: -1.37; 95% CI: -3.68, 0.94; P = 0.24; I2 = 97%) and (MD: -1.76; 95% CI: -4.06, 0.53; P = 0.13; I2 = 95%); however, at 24 hours the scores were better in the tizanidine group (MD: -1.10; 95% CI: -1.50, -0.69; P < 0.0001 I2 = 0%). Although dry mouth was significantly more in the tizanidine group (MD: 5.35; 95% CI: 1.72, 16.62; P = 0.004; I2 = 0%), postoperative nausea/vomiting and dizziness were comparable. Tizanidine reduces intraoperative opioid consumption without significant adverse events. However, it does not provide effective opioid-sparing analgesia or reduced opioid requirement in the first 24 hours after surgery.
Periodicity in the cumulative hierarchy
Authors: Goldberg Gabriel , Schlutzenberg Farmer
Published: March 2023

We investigate the structure of rank-to-rank elementary embeddings at successor rank, working in

\mathrm{ZF}

set theory without the Axiom of Choice. Recall that the set-theoretic universe is naturally stratified by the cumulative hierarchy, whose levels

V_\alpha

are defined via iterated application of the power set operation, starting from

V_0=\emptyset

, setting

V_{\alpha+1}=\mathcal{P}(V_\alpha)

, and taking unions at limit stages. Assuming that

j:V_{\alpha+1}\to V_{\alpha+1}

is a (non-trivial) elementary embedding, we show that

V_\alpha

is fundamentally different from

V_{\alpha+1}

: we show that

j

is definable from parameters over

V_{\alpha+1}

iff

\alpha+1

is an odd ordinal. The definability is uniform in odd

\alpha+1

and

j

. We also give a characterization of elementary

j:V_{\alpha+2}\to V_{\alpha+2}

in terms of ultrapower maps via certain ultrafilters.

For limit ordinals

\lambda

, we prove that if

j:V_\lambda\to V_\lambda

is

\Sigma_1

-elementary, then

j

is not definable over

V_\lambda

from parameters, and if

\beta<\lambda

and

j:V_\beta\to V_\lambda

is fully elementary and

\in

-cofinal, then

j

is likewise not definable.

If there is a Reinhardt cardinal, then for all sufficiently large ordinals

\alpha

, there is indeed an elementary

j:V_\alpha\to V_\alpha

, and therefore the cumulative hierarchy is eventually
periodic
(with period 2).
Geometric Structures in Group Theory
Authors: Bridson Martin R. , Druţu Cornelia , Kramer Linus , Rémy Bertrand
Published: March 2023

The conference was in the area of geometric group theory, the field of mathematics in which one studies infinite groups (finitely generated, or more generally locally compact, countable etc.) via actions on spaces endowed with various structures (geometric, measurable, analytic etc.). The surging current activity in the field is drawing more and more connections with other mathematical areas, and this was successfully reflected in the program of this week, during which problems in algebraic topology, representation theory and functional analysis, to name just a few, featured prominently alongside core topics in the area.
New Mathematical Techniques in Information Theory
Authors: Lapidoth Amos , Narayan Prakash
Published: March 2023

Information theory is the richer for a surge of recent advances in relevant mathematical techniques. The workshop fostered an exchange of ideas on new mathematical tools which are typically outside the classical toolbox of information theorists and that are yet useful in solving classical and modern problems in information theory and related areas. The focus was on mathematical techniques that are of a general nature and that could benefit a wide class of problems. A number of broad mathematical areas were identified that held promise with established early successes, and key contributors were invited to make presentations and initiate discussions with an emphasis on emergent topics. The areas were: information measures, measure concentration, hypercontractivity and correlation measures, Shannon theory and extremal combinatorics, advanced tools for proving converse results in coding theorems, and recent techniques for proving Gaussian optimality entailing new characterizations of Gaussian distributions.
Groups and Dynamics: Topology, Measure, and Borel Structure
Authors: Kerr David , Tserunyan Anush , Tucker-Drob Robin D.
Published: March 2023

While the subjects of topological dynamics, ergodic theory, and descriptive set theory have long interacted in a variety of profitable ways, recent developments have ushered in a vigorous new phase of interplay between them, from the abstract transfer and coordinated development of ideas and methods (as in the theory of dynamical tilings) to the direct leveraging of technical points of contact (as in boundary theory). The workshop served as a platform for promoting and advancing these connections by bringing together researchers working on various facets of topological, measured, and Borel dynamics.