bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Assessment of MCR-1 Gene among Pandrug-Resistant Acinetobacter baumannii
Authors: Sobieh Shaimaa S. , Mohamed Shereen A. H. , El-Sayed Manal A. , Abdallah Soad A.
Published: August 2023

Background Antimicrobial resistance has become one of the most widespread threats to humans. Acinetobacter baumannii is one of the pathogens responsible for healthcare-associated infections (nosocomial). Colistin is considered the last resort antibiotic against infections with pandrug-resistant (PDR) pathogens. Results: Eleven isolates were detected phenotypically as PDR A. baumannii and were confirmed molecularly using 16S rDNA. The MCR-1 gene was not detected within the chromosomal DNA of the selected isolates. Plasmid bearing the MCR-1 gene was identified in 10 selected isolates of A. baumannii that had not been previously observed to carry the MCR-1 gene. Moreover, the use of colistin in combination with anionic antibiotics or natural compound pterostilbene poses a viable therapeutic alternative for PDR and revives colistin’s bactericidal effects on MCR-1-positive A. baumannii. Finally, the transmission electron microscopy studies proved the synergistic effect of these combinations and revealed the disruption of resistant A. baumannii’s outer membrane and alteration of the permeability properties that allowed overcoming the resistance of the isolates to colistin. Conclusions: Antimicrobial resistance of A. baumannii is related to the presence of the transferable plasmid-bearing MCR-1 gene. This study proved the ability of the combinations of colistin with anionic antibiotics and/or natural compound pterostilbene to restore the bactericidal effect of colistin. Overall, these combinations could be novel promising clinical alternatives against the increasing threat of the widespread multidrug-resistant A. baumannii.
Arbuscular Mycorrhizal Fungus Funneliformis mosseae Improves Soybean Growth Even in Soils with Good Nutrition
Authors: Řezáčová Veronika , Némethová Ema , Stehlíková Iva , Czakó Alena , Gryndler Milan
Published: August 2023

Arbuscular mycorrhizal fungi (AMF) improve plant growth and may be useful in maintaining and even restoring soil. However, data on the latter function are sparse and only indirect, which is especially true for conventional management conditions with adequate nutrient availability. Our study focused on utilizing the prevalent AMF species, Funneliformis mosseae, to enhance Glycine max production, while also exploring its partly explored impact on soil aggregation. Working in greenhouse conditions, we examined whether, in a nutrient-sufficient environment, AMF would improve crop biomass accumulation and nutrition, as well as the stability of soil aggregates (SAS). We also looked for a synergistic effect of dual inoculation using AMF and symbiotic rhizobium. Plants were or were not inoculated with AMF or Bradyrhizobium japonicum in a two-factorial design. AMF inoculation increased soybean biomass, but AMF inoculation had no impact on P and N input to the shoots. Mycorrhiza did not affect either glomalin abundance or SAS. All the impacts were, however, independent from rhizobial inoculation, which was ineffective in this nutrient-available environment. Our assay suggests that arbuscular mycorrhiza may have a positive effect on soybean growth even under conventional management with adequate nutrition. The positive effects of AMF on soybean growth, together with the fact that AMF generally do not thrive in good nutrient availability, should be taken into account when planning mineral fertilization levels.
The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut–Brain Axis Development and Life-Long Health Outcomes
Authors: Sajdel-Sulkowska Elizabeth M.
Published: August 2023

Gut microbiota plays a critical role in physiological regulation throughout life and is specifically modified to meet the demands of individual life stages and during pregnancy. Maternal gut microbiota is uniquely adapted to the pregnancy demands of the mother and the developing fetus. Both animal studies in pregnant germ-free rodents and human studies have supported a critical association between the composition of maternal microbiota during pregnancy and fetal development. Gut microbiota may also contribute to the development of the fetal gut–brain axis (GBA), which is increasingly recognized for its critical role in health and disease. Most studies consider birth as the time of GBA activation and focus on postnatal GBA development. This review focuses on GBA development during the prenatal period and the impact of maternal gut microbiota on fetal GBA development. It is hypothesized that adaptation of maternal gut microbiota to pregnancy is critical for the GBA prenatal development and maturation of GBA postnatally. Consequently, factors affecting maternal gut microbiota during pregnancy, such as maternal obesity, diet, stress and depression, infection, and medication, also affect fetal GBA development and are critical for GBA activity postnatally. Altered maternal gut microbiota during gestation has been shown to have long-term impact postnatally and multigenerational effects. Thus, understanding the impact of maternal gut microbiota during pregnancy on fetal GBA development is crucial for managing fetal, neonatal, and adult health, and should be included among public health priorities.
Using Cryopreserved Plasmodium falciparum Sporozoites in a Humanized Mouse Model to Study Early Malaria Infection Processes and Test Prophylactic Treatments
Authors: Jiménez-Díaz María-Belén , Möhrle Jörg J. , Angulo-Barturen Iñigo , Demarta-Gatsi Claudia
Published: August 2023

In addition to vector control, long-lasting insecticidal nets and case management, the prevention of infection through vaccination and/or chemoprevention are playing an increasing role in the drive to eradicate malaria. These preventative approaches represent opportunities for improvement: new drugs may be discovered that target the early infectious stages of the Plasmodium parasite in the liver (rather than the symptomatic, abundant blood stage), and new, exciting vaccination technologies have recently been validated (using mRNA or novel adjuvants). Exploiting these possibilities requires the availability of humanized mouse models that support P. falciparum infection yet avoid the hazardous use of infectious mosquitoes. Here, we show that commercially available P. falciparum sporozoites and FRG mice carrying human hepatocytes and red blood cells faithfully recapitulate the early human malaria disease process, presenting an opportunity to use this model for the evaluation of prophylactic treatments with a novel mode of action.
Microbiological Quality and Safety of Fresh Quail Meat at the Retail Level
Authors: Martinez-Laorden Alba , Arraiz-Fernandez Celia , Gonzalez-Fandos Elena
Published: August 2023

The objective of this study was to evaluate the microbiological quality and safety of 37 fresh quail meats. Mesophiles, Pseudomonas spp., Enterobacteriaceae, and staphylococci counts were 5.25 ± 1.14, 3.92 ± 1.17, 3.09 ± 1.02, and 2.80 ± 0.64 log CFU/g, respectively. Listeria monocytogenes was detected in seven samples (18.92%). Campylobacter jejuni was detected in one sample (2.70%). Clostridium perfringens was not detected in any sample. The dominant bacteria were Pseudomonas spp. (30.46%), Micrococcaceae (19.87%), lactic acid bacteria (14.57%), and Enterobacteriaceae (11.92%). Brochotrix thermosphacta and enterococci were isolated to a lesser extent, 7.28% and 1.99%, respectively. The dominant Enterobacteriaceae found were Escherichia coli (42.53%). ESBL-producing E. coli was detected in one sample (2.70%), showing resistance to 16 antibiotics. Sixteen different Staphylococcus spp. and three Mammaliicoccus spp. were identified, the most common being S. cohnii (19.86%) and M. sciuri (17.02%). S. aureus and S. epidermidis were also found in one and four samples, respectively. Methicillin-resistant M. sciuri and S. warneri were found in 13.51% and 10.81% of quail samples, respectively. These bacteria showed an average of 6.20 and 18.50 resistances per strain, respectively. The high resistance observed in ESBL-producing E. coli and methicillin-resistant S. warneri is of special concern. Measures should be adopted to reduce the contamination of quail meat.
Hierarchical Intelligent Control Method for Mineral Particle Size Based on Machine Learning
Authors: Zou Guobin , Zhou Junwu , Song Tao , Yang Jiawei , Li Kang
Published: August 2023

Mineral particle size is an important parameter in the mineral beneficiation process. In industrial processes, the grinding process produces pulp with qualified particle size for subsequent flotation processes. In this paper, a hierarchical intelligent control method for mineral particle size based on machine learning is proposed. In the machine learning layer, artificial intelligence technologies such as long and short memory neural networks (LSTM) and convolution neural networks (CNN) are used to solve the multi-source ore blending prediction and intelligent classification of dry and rainy season conditions, and then the ore-feeding intelligent expert control system and grinding process intelligent expert system are used to coordinate the production of semi-autogenous mill and Ball mill and Hydrocyclone (SAB) process and intelligently adjust the control parameters of DCS layer. This paper presents the practical application of the method in the SAB production process of an international mine to realize automation and intelligence. The process throughput is increased by 6.05%, the power consumption is reduced by 7.25%, and the annual economic benefit has been significantly improved.
Native Gold and Unique Gold–Brannerite Nuggets from the Placer of the Kamenny Stream, Ozerninsky Ore Cluster (Western Transbakalia, Russia) and Possible Sources
Authors: Zhmodik Sergey M. , Airiyants Evgeniya V. , Belyanin Dmitriy K. , Damdinov Bulat B. , Karmanov Nikolay S. , Kiseleva Olga N. , Kozlov Alexander V. , Mironov Alexander A. , Moroz Tatyana N. , Ponomarchuk Victor A.
Published: August 2023

We carried out a comprehensive study of native gold (morphology, composition, intergrowths, and microinclusions) from alluvial deposits of the Kamenny stream (Ozerninsky ore cluster, Western Transbaikalia, Russia). The study showed that there were four types of native gold, which differed significantly in their characteristics and probably had different primary sources from which placers were formed: gold–quartz, oxidized gold–sulfide, gold–silver, and zones of listvenites with copper–gold and gold–brannerite (Elkon-type). Particular attention was paid to the study of unique, both in size and in composition, gold–brannerite nuggets of the Kamenny stream. It was established that the gold in the gold–brannerite nuggets (GBNs) had wide variations in chemical composition and mineral features. According to them, there were five different fineness types of native gold: 750–800‰; 850–880‰; 880–920‰; 930–960‰; and 980–1000‰. The data obtained indicated a multistage, possibly polygenic, and probably polychronous formation of GBN gold–uranium mineralization. The first stage was the formation of early quartz–nasturanium–gold–W–rutile–magnetite association (Middle–Late Paleozoic age). The second was the crystallization of brannerite and the replacement of an earlier pitchblende with brannerite (Late Triassic (T3)–Early Jurassic (J1) age). The third was the formation of the hematite–barite–rutile–gold association as a result of deformation–hydrothermal processes, which was associated with the appearance of zones of alteration in brannerite in contact with native gold with 8–15 wt.% Ag. The fourth was hypergene or the low-temperature hydrothermal alteration of minerals of early stages with the development of iron hydroxides (goethite) with impurities of manganese, tellurium, arsenic, phosphorus, and other elements. The carbon isotopic composition of an organic substance indicates the involvement of a biogenic carbon source. In the OOC area, there were signs that the composition of the GBNs and the quartz–chlorite–K–feldspar-containing rocks corresponded to Elkon-type deposits.
Strongly Peraluminous Highly Fractionated I-Type Granite from Bangong–Nujiang Metallogenic Belt, Tibet: Implications for Continental Evolution and Evaluation of Economic Potentiality
Authors: Wang Nan , Liu Zhibo , Lei Min
Published: August 2023

The research on highly fractionated granite has significant implications for both the evolution and compositional maturation of the continental crust and metallogenic exploration. As a means of further understanding crustal evolution and promoting ore exploration in the Bangong–Nujiang metallogenic belt (BNMB), we present the petrography, zircon LA–ICP–MS U–Pb age, and Hf isotopic data, along with the whole-rock geochemical and Sr–Nd isotopic composition on Kese highly fractionated granite in the Baingoin area within the BNMB, central Tibet. The results show that Kese granite possesses a zircon U–Pb age of 127.8 ± 1.7 Ma and a relative enrichment in zircon Hf isotopic composition (−12.8~+0.3) with a two-stage Hf model age of 1.2~2.0 Ga. This granite belongs to the high-K calc-alkaline series, characterized by a strongly peraluminous feature, and is enriched in large-ion lithophile elements (LILEs) and Nd isotopes (−7.86~−7.74). The granite was likely to have been derived from the mixed melts derived from 40%~45% juvenile basaltic lower crust, 15%~20% ancient lower, and 40% middle–upper, following intense fractional crystallization processes involving amphibole, biotite, plagioclase, and some accessory minerals during the magma’s evolution. We infer that Kese highly fractionated granite can be formed from the continental collision of the Lhasa–Qiangtang terranes initiated before 128 Ma. The reworking of pre-existing juvenile and ancient crustal materials drove the composition of the northern Lhasa terrane to that of a mature continental crust. Moreover, the distinctive geochemical features have shown that the high degree of differentiation led to intense magmatic–hydrothermal interaction during the formation of Kese granite. A comparison of the geochemical characteristics of mineralized and barren granites suggests that the highly fractionated granites in Baingoin from the BNMB have a high economic potential and are suitable for preliminary exploration of Sn–W-(U) deposits.
Study on the Galvanic Interaction of Gold and Main Associated Minerals Based on Density Functional Theory
Authors: Wang Miao , Li Wenjuan , Le Guan , Chen Jianhua , Yang Xi , Li Yuqiong , Huang Shuyu , Wen Jiankang , Song Yongsheng
Published: August 2023

The galvanic interaction of gold and associated sulfide minerals in thiocyanate systems has a significant impact on gold leaching. The density functional theory was used to further reveal the galvanic interaction between gold and associated minerals. The electron transfer between gold and its associated minerals at different galvanic interaction distances was simulated. The results show that with the increase of the contact distance between pyrite and gold, the charge of pyrite increases, indicating that it is losing electrons gradually; the charge of arsenopyrite and chalcocite decreases with the rise of the contact distance between gold and pyrite, suggesting that they are gaining electrons. In addition, gold has the greatest influence on the gain and loss of electrons in pyrite and arsenopyrite and has the least influence on chalcocite. Through the calculation of the density of states, it is found that different distances of galvanic interaction have a great influence on the density of states of surface atoms under the action of pyrite and arsenopyrite with gold but have little effect on the density of states of surface atoms under the action of chalcocite with gold.
Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases
Authors: Yamashita Shinji , Miyazawa Taiki , Higuchi Ohki , Kinoshita Mikio , Miyazawa Teruo
Published: August 2023

Aging increases oxidative and inflammatory stress caused by a reduction in metabolism and clearance, thus leading to the development of age-associated diseases. The quality of our daily diet and exercise is important for the prevention of these diseases. Marine resources contain various valuable nutrients, and unique glycerophospholipid plasmalogens are found abundantly in some marine invertebrates, including ascidians. One of the major classes, the ethanolamine class (PlsEtn), exists in a high ratio to phospholipids in the brain and blood, while decreased levels have been reported in patients with age-associated diseases, including Alzheimer’s disease. Animal studies have shown that the administration of marine PlsEtn prepared from marine invertebrates improved PlsEtn levels in the body and alleviated inflammation. Animal and human studies have reported that marine PlsEtn ameliorates cognitive impairment. In this review, we highlight the biological significance, relationships with age-associated diseases, food functions, and healthcare materials of plasmalogens based on recent knowledge and discuss the contribution of marine plasmalogens to health maintenance in aging.
From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs
Authors: Nordio Giulia , Piazzola Francesco , Cozza Giorgio , Rossetto Monica , Cervelli Manuela , Minarini Anna , Basagni Filippo , Tassinari Elisa , Dalla Via Lisa , Milelli Andrea , Di Paolo Maria Luisa
Published: August 2023

Monoamine oxidases (MAOs) are well-known pharmacological targets in neurological and neurodegenerative diseases. However, recent studies have revealed a new role for MAOs in certain types of cancer such as glioblastoma and prostate cancer, in which they have been found overexpressed. This finding is opening new frontiers for MAO inhibitors as potential antiproliferative agents. In light of our previous studies demonstrating how a polyamine scaffold can act as MAO inhibitor, our aim was to search for novel analogs with greater inhibitory potency for human MAOs and possibly with antiproliferative activity. A small in-house library of polyamine analogs (2–7) was selected to investigate the effect of constrained linkers between the inner amine functions of a polyamine backbone on the inhibitory potency. Compounds 4 and 5, characterized by a dianiline (4) or dianilide (5) moiety, emerged as the most potent, reversible, and mainly competitive MAO inhibitors (Ki < 1 μM). Additionally, they exhibited a high antiproliferative activity in the LN-229 human glioblastoma cell line (GI50 < 1 μM). The scaffold of compound 5 could represent a potential starting point for future development of anticancer agents endowed with MAO inhibitory activity.
Drug Reprofiling to Identify Potential HIV-1 Protease Inhibitors
Authors: Okafor Sunday N. , Meyer Abigail , Gadsden Jay , Ahmed Fadi , Guzmán Lilian , Ahmed Hashim , Romero José A. Fernández , Angsantikul Pavimol
Published: August 2023

The use of protease inhibitors in human immunodeficiency virus type 1 (HIV-1) treatment is limited by adverse effects, including metabolic complications. To address these challenges, efforts are underway in the pursuit of more potent and less toxic HIV-1 protease inhibitors. Repurposing existing drugs offers a promising avenue to expedite the drug discovery process, saving both time and costs compared to conventional de novo drug development. This study screened FDA-approved and investigational drugs in the DrugBank database for their potential as HIV-1 protease inhibitors. Molecular docking studies and cell-based assays, including anti-HIV-1 in vitro assays and XTT cell viability tests, were conducted to evaluate their efficacy. The study findings revealed that CBR003PS, an antibiotic currently in clinical use, and CBR013PS, an investigational drug for treating endometriosis and uterine fibroids, exhibited significant binding affinity to the HIV-1 protease with high stability. Their EC50 values, measured at 100% cell viability, were 9.4 nM and 36.6 nM, respectively. Furthermore, cell-based assays demonstrated that these two compounds showed promising results, with therapeutic indexes higher than 32. In summary, based on their favorable therapeutic indexes, CBR003PS and CBR013PS show potential for repurposing as HIV-1 protease inhibitors.
Direct Homogeneous Synthesis of Compounds with Two O Atoms and Long-Chain Hydrocarbons from CO and H2: Co–Ru/N-methylpyrrolidone Catalyst
Authors: Maximov Anton Lvovich , Kulikova Mayya V. , Kuz’min Alexey E. , Ivantsov Mikhail I.
Published: August 2023

The homogeneous acetic acid synthesis-type Ru–Co–Li/N-methylpyrrolidone catalyst for CO and H2 transformations has been studied at moderately high pressures. For 1CO:2H2, low acetic acid selectivity has been observed, along with remarkable methyl acetate selectivity, the absence of aldehydes and ethyl acetate and sharp deviations from the Anderson-Schultz-Flory distribution for both alcaohols and long-chain hydrocarbons. For 1CO:1H2 and slightly elevated pressure, acetic acid selectivity slightly increased, notable ethyl acetate formation was detected, and both long-chain hydrocarbons and alcohols disappeared. Hypotheses are discussed about the direct parallel formation of all observed product groups (hydrocarbons, alcohols, esters, and acetic acid) and hydrocarbon chain growth limitations according to the formed Ru–Co cluster size in the presence of the aforementioned catalytic system.
Synthesis and Characterization of New Triazole-Bispidinone Scaffolds and Their Metal Complexes for Catalytic Applications
Authors: Rossetti Arianna , Sacchetti Alessandro , Meneghetti Fiorella , Colombo Dugoni Greta , Mori Matteo , Castellano Carlo
Published: August 2023

Bispidines are a family of ligands that plays a pivotal role in various areas of coordination chemistry, with applications in medicinal chemistry, molecular catalysis, coordination polymers synthesis, and molecular magnetism. In the present work, triazole moieties were introduced using the CuAAC click-reaction, with the aim of expanding the number of coordination sites on the bispidine core. The 1,2,3-triazole rings were thus synthesized on propargyl-derived bispidines after reaction with different alkyl azides. The new class of triazole-bispidines was characterized, and their chelation capabilities were evaluated with different metals through NMR titration, ESI-MS spectrometry, and single-crystal X-ray diffraction (SC-XRD). Finally, the suitability of these molecules as metal ligands for the catalytic Henry reaction was demonstrated with copper and zinc.
Engineered Biomaterials Trigger Remineralization and Antimicrobial Effects for Dental Caries Restoration
Authors: Li Yuexiao , Liu Minda , Xue Mingyu , Kang Yuanyuan , Liu Dongjuan , Wen Yan , Zhao Duoyi , Guan Boyu
Published: August 2023

Dental caries is the most prevalent chronic disease globally, significantly impacting individuals’ quality of life. A key reason behind the failure of implanted restorations is their biological inactivity, meaning they are unable to form crosslinks with the surrounding tooth structures, thus making patients susceptible to implant loss and recurrent tooth decay. For the treatment of caries, antibacterial medicine and remineralization are effective means of treating the recurrence of caries. Owing to the rapid progression in the biomaterials field, several biomaterials have been reported to display antimicrobial properties and aid in dentin remineralization. Bioactive materials hold considerable potential in diminishing biofilm accumulation, inhibiting the process of demineralization, enabling dentin remineralization, and combating bacteria related to caries. Bioactive materials, such as fluoride, amorphous calcium phosphate, bioactive glass, collagen, and resin-based materials, have demonstrated their effectiveness in promoting dentin remineralization and exerting antibacterial effects on dental caries. However, the concentration of fluoride needs to be strictly controlled. Although amorphous calcium phosphate can provide the necessary calcium and phosphorus ions for remineralization, it falls short in delivering the mechanical strength required for oral mastication. Resin-based materials also offer different advantages due to the complexity of their design. In this review, we delve into the application of advanced bioactive materials for enhancing dentin remineralization and antibacterial properties. We eagerly anticipate future developments in bioactive materials for the treatment of dental caries.
Ligand-Free Signaling of G-Protein-Coupled Receptors: Physiology, Pharmacology, and Genetics
Authors: Sadee Wolfgang
Published: August 2023

G-protein-coupled receptors (GPCRs) are ubiquitous sensors and regulators of cellular functions. Each GPCR exists in complex aggregates with multiple resting and active conformations. Designed to detect weak stimuli, GPCRs can also activate spontaneously, resulting in basal ligand-free signaling. Agonists trigger a cascade of events leading to an activated agonist-receptor G-protein complex with high agonist affinity. However, the ensuing signaling process can further remodel the receptor complex to reduce agonist affinity, causing rapid ligand dissociation. The acutely activated ligand-free receptor can continue signaling, as proposed for rhodopsin and μ opioid receptors, resulting in robust receptor activation at low agonist occupancy with enhanced agonist potency. Continued receptor stimulation can further modify the receptor complex, regulating sustained ligand-free signaling—proposed to play a role in opioid dependence. Basal, acutely agonist-triggered, and sustained elevated ligand-free signaling could each have distinct functions, reflecting multi-state conformations of GPCRs. This review addresses basal and stimulus-activated ligand-free signaling, its regulation, genetic factors, and pharmacological implications, focusing on opioid and serotonin receptors, and the growth hormone secretagogue receptor (GHSR). The hypothesis is proposed that ligand-free signaling of 5-HT2A receptors mediate therapeutic effects of psychedelic drugs. Research avenues are suggested to close the gaps in our knowledge of ligand-free GPCR signaling.
Antimicrobial Coatings for Medical Textiles via Reactive Organo-Selenium Compounds
Authors: Hoque Ejajul , Tran Phat , Jacobo Unique , Bergfeld Nicholas , Acharya Sanjit , Shamshina Julia L. , Reid Ted W. , Abidi Noureddine
Published: August 2023

Bleached and cationized cotton fabrics were chemically modified with reactive organoselenium compounds through the nucleophilic aromatic substitution (SNAr) reaction, which allowed for organo-selenium attachment onto the surface of cotton fabrics via covalent bonds and, in the case of the cationized cotton fabric, additional ionic interactions. The resulting textiles exhibited potent bactericidal activity against S. aureus (99.99% reduction), although only moderate activity was observed against E. coli. Fabrics treated with reactive organo-selenium compounds also exhibited fungicidal activities against C. albicans, and much higher antifungal activity was observed when organo-selenium compounds were applied to the cationized cotton in comparison to the bleached cotton. The treatment was found to be durable against rigorous washing conditions (non-ionic detergent/100 °C). This paper is the first report on a novel approach integrating the reaction of cotton fabrics with an organo-selenium antimicrobial agent. This approach is attractive because it provides a method for imparting antimicrobial properties to cotton fabrics which does not disrupt the traditional production processes of a textile mill.
Four-Point Measurement Setup for Correlative Microscopy of Nanowires
Authors: Pruchnik Bartosz C. , Fidelus Janusz D. , Gacka Ewelina , Kwoka Krzysztof , Pruchnik Julia , Piejko Adrianna , Usydus Łukasz , Zaraska Leszek , Sulka Grzegorz D. , Piasecki Tomasz , Gotszalk Teodor P.
Published: August 2023

The measurement method, which utilizes nanomanipulation of the nanowires onto a specially prepared substrate, was presented. It introduced a four-point resistance measurement setup on a chip suited for scanning probe microscopy measurements, integrating connectors and a nanowire specimen. A study on the resistance and resistivity of the thermally post-treated ZnO nanowires at 200 °C and 300 °C in air showed the dependence of these electrical parameters on the annealing temperature. The investigations of the electrical properties of blocks built on the basis of nanowires and their related devices could provide a useful guide not only for designing, fabricating and optimizing electromechanical nanodevices based on nanowires but also for their safe operation in future electronic applications.
Coherent Spin Dynamics of Electrons in CsPbBr3 Perovskite Nanocrystals at Room Temperature
Authors: Meliakov Sergey R. , Zhukov Evgeny A. , Kulebyakina Evgeniya V. , Belykh Vasilii V. , Yakovlev Dmitri R.
Published: August 2023

Coherent spin dynamics of charge carriers in CsPbBr3 perovskite nanocrystals are studied in a temperature range of 4–300 K and in magnetic fields of up to 500 mT using time-resolved pump-probe Faraday rotation and differential transmission techniques. We detect electron spin Larmor precession in the entire temperature range. At temperatures below 50 K, hole spin precession is also observed. The temperature dependences of spin-related parameters, such as Landè g-factor and spin dephasing time are measured and analyzed. The electron g-factor increases with growing temperature, which can not be described by the temperature-induced band gap renormalization. We find that photocharging of the nanocrystals with either electrons or holes depends on the sample cooling regime, namely the cooling rate and illumination conditions. The type of the charge carrier provided by the photocharging can be identified via the carrier spin Larmor precession.
Self-Healable PEDOT:PSS-PVA Nanocomposite Hydrogel Strain Sensor for Human Motion Monitoring
Authors: Cao Jie , Zhang Zhilin , Li Kaiyun , Ma Cha , Zhou Weiqiang , Lin Tao , Xu Jingkun , Liu Ximei
Published: August 2023

Strain sensors based on conducting polymer hydrogels are considered highly promising candidates for wearable electronic devices. However, existing conducting polymer hydrogels are susceptible to aging, damage, and failure, which can greatly deteriorate the sensing performance of strain sensors based on these substances and the accuracy of data collection under large deformation. Developing conductive polymer hydrogels with concurrent high sensing performance and self-healing capability is a critical yet challenging task to improve the stability and lifetime of strain sensors. Herein, we design a self-healable conducting polymer hydrogel by compositing poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) nanofibers and poly(vinyl alcohol) (PVA) via both physical and chemical crosslinking. This PEDOT:PSS-PVA nanocomposite hydrogel strain sensor displays an excellent strain monitoring range (>200%), low hysteresis (<1.6%), a high gauge factor (GF = 3.18), and outstanding self-healing efficiency (>83.5%). Electronic skins based on such hydrogel strain sensors can perform the accurate monitoring of various physiological signals, including swallowing, finger bending, and knee bending. This work presents a novel conducting polymer hydrogel strain sensor demonstrating both high sensing performance and self-healability, which can satisfy broad application scenarios, such as wearable electronics, health monitoring, etc.
The Impact of the COVID-19 Pandemic on Binge Eating Disorder: A Systematic Review
Authors: Caldiroli Alice , La Tegola Davide , Manzo Francesca , Scalia Alberto , Affaticati Letizia Maria , Capuzzi Enrico , Colmegna Fabrizia , Argyrides Marios , Giaginis Constantinos , Mendolicchio Leonardo , Buoli Massimiliano , Clerici Massimo , Dakanalis Antonios
Published: August 2023

The aim of this systematic review was to synthesise the impact of the COVID-19 pandemic on binge eating disorder (BED) the new onset and course. Inclusion criteria: original articles and BED diagnosis; and the main outcomes: relationships between the COVID-19 pandemic and the new onset/clinical changes in BED, and specific results for BED. Exclusion criteria: mixed/inaccurate diagnoses and articles not written in English. We searched four databases and one registry until 5 May 2023. The quality appraisal was conducted using the Effective Public Health Practice Project (EPHPP) tool. Twelve studies with 4326 participants were included. All studies were observational with nine cross-sectional and three longitudinal. Four of the included studies investigated new-onset BED, while eight examined the BED clinical course of patients with a previous diagnosis. With the exception of one study, the available literature indicates both an increase in BED diagnoses and a clinical worsening during COVID-19. Major limitations include study quality (weak-to-moderate) and high heterogeneity in terms of pandemic phase, population, geographical areas, and psychometric tools. Our findings indicate that BED patients are particularly vulnerable to events characterised by social distancing and over-worry, and should be, therefore, carefully monitored. Further studies are needed to corroborate our findings, implement preventive strategies, and promote personalised treatments. PROSPERO registration number: CRD42023434106
The Relationship between Diet and the Occurrence of Depressive Symptoms in a Community Example with High Rates of Social Deprivation: A Cross-Sectional Study
Authors: Nowicki Grzegorz Józef , Polak Maciej , Ślusarska Barbara , Czernecki Karol
Published: August 2023

Research suggests that various biological and psychosocial mechanisms are involved in the heterogeneous and complex relationship between dietary patterns and depressive symptoms. The occurrence of depressive symptoms is thought to be related to socioeconomic status (SES), with those with lower SES being more likely to experience persistent depression. The aim of the undertaken study was to investigate whether socioeconomic and health variables are associated with dietary assessment in a population with high rates of social deprivation and whether a relationship exists between dietary assessment and depressive symptoms (DS). The respondents’ nutrition was evaluated through a qualitative method, using the Perinumeric Periodic Table questionnaire by Starzyńska. At the same time, the prevalence of DS was assessed employing the Patient Health Questionnaire-9 (PHQ-9). In the DS screening (PHQ-9 ≥ 10), in the entire study population, the risk of DS was 16.1% (n = 605). In our entire study population, up to 61.2% (n = 2297) of the respondents exhibited poor dietary patterns. In the multivariate model, women with almost adequate or poor dietary assessment were 1.62 and 2.18 times more likely to score at least 10 on the PHQ-9 questionnaire, as compared to women whose dietary assessment was good or adequate. In conclusion, it was determined that sociodemographic variables affect nutritional habits. Women who lived in rural areas limited to a vocational education had significantly poorer diets. Moreover, men, younger men, smokers, and those without chronic diseases were characterized by a poorer dietary assessment. Additionally, women who had a better dietary assessment were significantly more likely to have lower scores on the questionnaire assessing the occurrence of DS (PHQ-9 10).
Sanguisorba officinalis L. Ameliorates Hepatic Steatosis and Fibrosis by Modulating Oxidative Stress, Fatty Acid Oxidation, and Gut Microbiota in CDAHFD-Induced Mice
Authors: Nam Yunseong , Kim Myungsuk , Erdenebileg Saruul , Cha Kwang Hyun , Ryu Da Hye , Kim Ho Youn , Lee Su Hyeon , Jung Je Hyeong , Nho Chu Won
Published: August 2023

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver diseases and encompasses non-alcoholic steatosis, steatohepatitis, and fibrosis. Sanguisorba officinalis L. (SO) roots have traditionally been used for their antioxidant properties and have beneficial effects on metabolic disorders, including diabetes and obesity. However, its effects on hepatic steatosis and fibrosis remain unclear. In this study, we explored the effects of a 95% ethanolic SO extract (SOEE) on NAFLD and fibrosis in vivo and in vitro. The SOEE was orally administered to C57BL/6J mice fed a choline-deficient, L-amino-acid-defined, high-fat diet for 10 weeks. The SOEE inhibited hepatic steatosis by modulating hepatic malondialdehyde levels and the expression of oxidative stress-associated genes, regulating fatty-acid-oxidation-related genes, and inhibiting the expression of genes that are responsible for fibrosis. The SOEE suppressed the deposition of extracellular matrix hydroxyproline and mRNA expression of fibrosis-associated genes. The SOEE decreased the expression of fibrosis-related genes in vitro by inhibiting SMAD2/3 phosphorylation. Furthermore, the SOEE restored the gut microbial diversity and modulated specific bacterial genera associated with NAFLD and fibrosis. This study suggests that SOEE might be the potential candidate for inhibiting hepatic steatosis and fibrosis by modulating oxidative stress, fatty acid oxidation, and gut microbiota composition.
Evaluation of the Content of Micro- and Macroelements in Raspberries Depending on the Species, Cultivar Variety, and Geographical Environment
Authors: Adamczuk Natalia , Ośko Justyna , Grembecka Małgorzata , Konieczyński Paweł , Migas Piotr , Orzeł Agnieszka , Baj-Wójtowicz Barbara , Krauze-Baranowska Mirosława
Published: August 2023

The study aimed to analyse the macro- and micro-nutrient content in fruits of Rubus species (R. idaeus, R. occidentalis, R. chamaemorus, and R. chingii) and their varieties or hybrids from different regions. Flame atomic absorption spectrometry with deuterium background correction was used to measure concentrations of nine essential elements (K, Mg, Ca, Na, Mn, Fe, Cr, Zn, and Cu) and two heavy metals (Pb, Cd). Chemometric analysis compared the elemental profiles. Results confirmed raspberries as a rich source of macroelements (K, Mg) and microelements (Zn, Cu, Mn, Cr). The ‘Bristol’ cultivar consistently had the highest Fe content regardless of origin. Cr presence was observed in black raspberries for the first time. Previously observed relationships like K-Na antagonism and Cr/Zn, Fe/Zn synergism were found in raspberry fruits. Factor and cluster analyses demonstrated species and geographical diversity among Polish raspberry samples and clear separation of R. chingii from China. Raspberry fruits, due to the rich complex of polyphenols, are classified as superfoods, and the content of bioelements determined in them guarantees coverage of the daily requirement for macro- and microelements (RDA depending on the element: 5.6–204% for R. idaeus, 8.8–469, 4% for R. occidentalis, and 1.4–67.2% for R. chamaemorus), finally confirming this opinion.
Dietary Diversity Changes and Cognitive Frailty in Chinese Older Adults: A Prospective Community-Based Cohort Study
Authors: Zhong Wen-Fang , Song Wei-Qi , Wang Xiao-Meng , Li Zhi-Hao , Shen Dong , Liu Dan , Zhang Pei-Dong , Shen Qiao-Qiao , Liang Fen , Nan Ying , Xiang Jia-Xuan , Chen Zi-Ting , Li Chuan , Li Shi-Tian , Lv Xiao-Gang , Lin Xiu-Rong , Lv Yue-Bin , Gao Xiang , Kraus Virginia Byers , Shi Xiao-Ming , Mao Chen
Published: August 2023

Evidence for the effects of dietary diversity changes and cognitive frailty (CF) in the older adults is not clear. This study aimed to investigate the relationship between dietary diversity changes and CF in older adults Chinese. A total of 14,382 participants (mean age: 82.3 years) were enrolled. Dietary diversity scores (DDSs) were collected and calculated using a food frequency questionnaire. DDS changes between baseline and first follow-up were categorized into nine patterns. The associations between DDS changes and the incidence of CF were estimated using Cox proportional hazards models. During an 80,860 person-year follow-up, 3023 CF cases were identified. Groups with a decrease in DDS had increased CF risk compared with the high-to-high DDS group, with adjusted hazard ratios (HRs; 95% confidence intervals (Cis)) of 1.30 (1.06, 1.59), 2.04 (1.51, 2.74), and 1.81 (1.47, 2.22) for high-to-medium, high-to-low, and medium-to-low groups, respectively. Lower overall DDS groups were associated with greater CF risks, with HRs (95% CIs) of 1.49 (1.19, 1.86) for the low-to-medium group and 1.96 (1.53, 2.52) for the low-to-low group. Compared with the high-to-high group, significant associations with CF were found in other DDS change groups; HRs ranged from 1.38 to 3.12 for the plant-based DDS group and from 1.24 to 1.32 for the animal-based DDS group. Additionally, extreme and moderate declines in overall DDS increased CF risk compared with stable DDS, with HRs (95% CIs) of 1.67 (1.50, 1.86) and 1.13 (1.03, 1.24), respectively. In conclusion, among older adults, a declining or persistently low DDS and a moderately or extremely declining DDS were linked to higher incident CF. Plant-based DDS changes correlated more strongly with CF than animal-based DDS changes.
Consumption of Extruded Sorghum SC319 Improved Gut Microbiota at Genus Level and Reduced Anthropometric Markers in Men with Overweight: A Randomized Controlled Clinical Trial
Authors: Lúcio Haira , Anunciação Pamella , da Silva Barbara , da Silva Alessandra , Queiroz Valéria , de Carvalho Carlos , Pinheiro-Sant’Ana Helena , Martino Hercia
Published: August 2023

Background: Sorghum is a cereal source of energy, carbohydrates, resistant starch, proanthocyanidins, and 3-deoxyanthocyanins; it promotes satiety by slowing digestion and benefits intestinal health. Objective: This study investigated the effects of extruded sorghum SC319 consumption on intestinal health, weight loss, and inflammatory markers in men with overweight. Methods: This was a randomized, controlled, single-blind clinical trial. Twenty-one men were randomly allocated into one of two groups: the sorghum group (test), which received 40 g of extruded SC319 whole sorghum (n = 10), or the wheat group (control), which received 38 g of extruded whole wheat (n = 11) for eight weeks. Results: The sorghum consumption increased the weight loss intragroup, decreased the body fat percentage intergroup, and did not change inflammatory markers, while the wheat group had increased IL-6 levels compared to baseline. Short-chain fatty acid production, fecal pH, and α and β diversity indexes did not differ intra- and intergroup after interventions. However, sorghum consumption decreased genus levels of Clostridium_sensu_stricto 1, Dorea, and Odoribacter and increased CAG-873 and Turicibacter compared to baseline. Further, sorghum showed a tendency (p = 0.07) to decrease the proteobacteria phyla compared to wheat. Conclusion: Extruded sorghum SC319 improved intestinal microbiota and body composition and promoted weight loss, demonstrating its prebiotic potential.
Feasibility of Home Parenteral Nutrition in Patients with Intestinal Failure Due to Neuroendocrine Tumours: A Systematic Review
Authors: Clement Dominique S. V. M. , Brown Sarah E. , Naghibi Mani , Cooper Sheldon C. , Tesselaar Margot E. T. , van Leerdam Monique E. , Ramage John K. , Srirajaskanthan Rajaventhan
Published: August 2023

Introduction: Maintaining adequate nutritional status can be a challenge for patients with small bowel neuroendocrine tumours (NETs). Surgical resection could result in short bowel syndrome (SBS), whilst without surgical resection there is a considerable risk of ischemia or developing an inoperable malignant bowel obstruction (IMBO). SBS or IMBO are forms of intestinal failure (IF) which might require treatment with home parenteral nutrition (HPN). Limited data exist regarding the use of HPN in patients with small bowel neuroendocrine tumours, and it is not frequently considered as a possible treatment. Methods: A systematic review was performed regarding patients with small bowel NETs and IF to report on overall survival and HPN-related complications and create awareness for this treatment. Results: Five articles regarding patients with small bowel NETs or a subgroup of patients with NETs could be identified, mainly case series with major concerns regarding bias. The studies included 60 patients (range 1–41). The overall survival time varied between 0.5 and 154 months on HPN. However, 58% of patients were alive 1 year after commencing HPN. The reported catheter-related bloodstream infection rate was 0.64–2 per 1000 catheter days. Conclusion: This systematic review demonstrates the feasibility of the use of HPN in patients with NETs and IF in expert centres with a reasonable 1-year survival rate and low complication rate. Further research is necessary to compare patients with NETs and IF with and without HPN and the effect of HPN on their quality of life.
Codonopsis lanceolata Extract Restores Smooth Muscle Vasorelaxation in Rat Carotid Arteries Even under High Extracellular K+ Concentrations
Authors: Kim Uihwan , Shin You Kyoung , Park Jubin , Seol Geun Hee
Published: August 2023

Recent studies showed that Codonopsis lanceolata (CL) has antihypertensive effects. However, to date, no study has examined the effects of CL on vascular tone under a high extracellular K+ concentration ([K+]o). Thus, the present study examined the effect of an extract of Codonopsis lanceolata (ECL) on the vascular tension of rat carotid arteries exposed to high [K+]o. We used myography to investigate the effect of an ECL on the vascular tension of rat carotid arteries exposed to high [K+]o and the underlying mechanism of action. In arteries with intact endothelia, the ECL (250 μg/mL) had no effect on vascular tension in arteries exposed to normal or high [K+]o. In contrast, the ECL significantly increased vasorelaxation in endothelium-impaired arteries exposed to a physiologically normal or high [K+]o compared with control arteries exposed to the same [K+]o conditions in the absence of ECL. This vasorelaxing action was unaffected by a broad-spectrum K+ channel blocker and an ATP-sensitive K+ channel blocker. The ECL significantly inhibited the vasoconstriction induced by Ca2+ influx through voltage-dependent Ca2+ channels (VDCCs) but not Ca2+ influx induced via receptor-operated Ca2+ channels or the release of Ca2+ from the sarcoplasmic reticulum in the vascular smooth muscle. In summary, our study reveals that the ECL acts through VDCCs in vascular smooth muscle to promote the recovery of vasorelaxation even in arteries exposed to high [K+]o in the context of endothelial dysfunction and provides further evidence of the vascular-protective effects of ECL.
Risk Factors for Food Insecurity among Older Adults in India: Study Based on LASI, 2017–2018
Authors: Fong Joelle H.
Published: August 2023

Background: Food security is linked to the nutritional status and well-being of older adults. India is a rapidly aging nation that ranks highly on the 2022 Global Hunger Index. This paper examines the prevalence and risk factors of food insecurity in India’s older population. Methods: We used data from the 2017–2018 Longitudinal Aging Study in India. The sample size was 31,532 adults aged 60 years and above. Food insecurity was measured using a four-item version of the Food Insecurity Experience scale. Multivariable logistic regressions using individual-level weights were implemented to assess the risk factors of food insecurity. Results: The prevalence of food insecurity was 10.5% in the weighted sample. Sociodemographic factors were important in explaining food insecurity. Older adults who were male, younger, lowly educated, socially disadvantaged, in rural areas, and outside the Northern region were most vulnerable to food insecurity, controlling for various confounders. Additionally, low economic status, no occupational pension, currently working, social isolation, physical impairment, functional disabilities, poor self-rated health, and arthritis were associated with an increased risk of food insecurity. Conclusions: More active food assistance programs catering to older adults and a better provision of economic and social security are warranted to establish a food-secure environment for rapidly aging India.