bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating plasma fibronectin affects tissue insulin sensitivity, adipocyte differentiation, and transcriptional landscape of adipose tissue in mice
Authors: Mahmoodi Mahdokht , Mirzarazi Dahagi Elahe , Nabavi Mir‐Hamed , Penalva Ylauna C. M. , Gosaine Amrita , Murshed Monzur , Couldwell Sandrine , Munter Lisa M. , Kaartinen Mari T.
Published: July 2024

Plasma fibronectin (pFN) is a hepatocyte‐derived circulating extracellular matrix protein that affects cell morphology, adipogenesis, and insulin signaling of adipocytes in vitro. In this study, we show pFN accrual to adipose tissue and its contribution to tissue homeostasis in mice. Hepatocyte‐specific conditional Fn1 knockout mice (Fn1−/−ALB) show a decrease in adipose tissue FN levels and enhanced insulin sensitivity of subcutaneous (inguinal), visceral (epididymal) adipose tissue on a normal diet. Diet‐induced obesity model of the Fn1−/−ALB mouse showed normal weight gain and whole‐body fat mass, and normal adipose tissue depot volumes and unaltered circulating leptin and adiponectin levels. However, Fn1−/−ALB adipose depots showed significant alterations in adipocyte size and gene expression profiles. The inguinal adipose tissue on a normal diet, which had alterations in fatty acid metabolism and thermogenesis suggesting browning. The presence of increased beige adipocyte markers Ucp1 and Prdm16 supported this. In the inguinal fat, the obesogenic diet resulted in downregulation of the browning markers and changes in gene expression reflecting development, morphogenesis, and mesenchymal stem cell maintenance. Epididymal adipose tissue showed alterations in developmental and stem cell gene expression on both diets. The data suggests a role for pFN in adipose tissue insulin sensitivity and cell profiles.
LncRNA MIR17HG alleviates heart failure via targeting MIR17HG/miR-153-3p/SIRT1 axis in in vitro model
Authors: Sun Shuai , Weng Jianxin , Chen Yun , Zheng Tingting , Li Yan , Zhu Jianfei , Chen Yanjun
Published: July 2024

Heart failure (HF) is a syndrome of symptoms and signs caused by cardiac insufficiency and have become a serious global health problem. The aim of this study is to clarify the role and mechanism failure of MIR17HG. We established the in vitro HF model by using H2O2-treated AC-16 and HCM cells, and the reactive oxygen species (ROS) level and natriuretic peptide precursor B (NPPB) expression were also detected. The RNA expression of MIR17HG, miR-153-3p, SIRT1, and NPPB were detected by quantitative reverse transcription PCR while the SIRT1 and NPPB expression were detected by western blot. The binding relationship among MIR17HG, miR-153-3p, and SIRT1 were assessed by dual-luciferase reporter assay and RNA binding protein immunoprecipitation assay. Then, MIR17HG and SIRT1 were overexpressed by lentivirus transfection, and the influence of MIR17HG and SIRT1 on H2O2-induced apoptosis mediated by p53 were evaluated. The results show that MIR17HG and SIRT1 were significantly downregulated, while miR-153-3p was significantly upregulated in HF model. Overexpression of MIR17HG reduced miR-153-3p and alleviated HF, while knockdown of SIRT1 weakened the effects of MIR17HG, suggesting that SIRT1 was the direct target of MIR17HG/miR-153-3p axis. MIR17HG is significantly downregulated in HF model. Our research shows that MIR17HG protects cardiomyocytes from ROS-induced damage via the MIR17HG/miR-153-3p/SIRT1 axis, suggesting that MIR17HG and SIRT1 are potential therapeutic targets in HF.
Pathological and physiological roles of ADP-ribosylation: established functions and new insights
Authors: Feijs-Žaja Karla L.H. , Ikenga Nonso J. , Žaja Roko
Published: July 2024

The posttranslational modification of proteins with poly(ADP-ribose) was discovered in the sixties. Since then, we have learned that the enzymes involved, the so-called poly(ADP-ribosyl)polymerases (PARPs), are transferases which use cofactor NAD+ to transfer ADP-ribose to their targets. Few PARPs are able to create poly(ADP-ribose), whereas the majority transfers a single ADP-ribose. In the last decade, hydrolases were discovered which reverse mono(ADP-ribosyl)ation, detection methods were developed and new substrates were defined, including nucleic acids. Despite the continued effort, relatively little is still known about the biological function of most PARPs. In this review, we summarise key functions of ADP-ribosylation and introduce emerging insights.
Methodology Used to Update the Gasoline Volatility Schedule for U.S. Seasonal and Geographic Classes
Authors:   ASTM International
Published: July 2024

Description

A team of stakeholders from ASTM Subcommittee D02.A on Gasoline and Oxygenated Fuels developed a revision to the seasonal and geographic volatility schedule for gasoline in the United States. The members of the team represented all classifications of the subcommittee: fossil and renewable fuels, automobile manufacturers, government regulators, logistics (shipping), and transport sectors. The team worked for two years with more than 1,300 hours of personal effort to revise this important schedule (see ASTM D4814, Standard Specification for Automotive Spark-Ignition Engine Fuel, Table 4). A volatility table has been included in ASTM D4814, and its predecessor ASTM D439-85a, Standard Specification for Automotive Gasoline (Withdrawn 1990), since the inception of these standard specifications. The original table was developed using weather data and decades of vehicle testing programs. This stakeholder group reviewed all of the historical and present data to develop volatility limits to provide a standard that should deliver acceptable driveability to the consumer.
Fotografar para conservar, relicários como medicina anti-esvaziamento
Authors: Bezerra Daniele Borges
Published: July 2024

Este ensaio apresenta fotografias e reflexões da autora relacionadas ao tema Fotografia e Memória. A autora propõe uma mostra de trabalhos de cunho fotográfico onde à tentativa de preservação da memória se expressa na metáfora configurada do relicário. Assim, a fotografia enquanto representação de uma coisa ausente é mantida em lugar privilegiado, quase sagrado, de proteção e rememoração. Pretende-se explorar o universo simbólico e subjetivo em torno da fotografia no que diz respeito à negação da morte e à busca por um tipo de perpetuação no tempo.
Tam Dişsiz Dental Arkların Dijital Kaydı: Güncel Yaklaşımlara Bir Bakış
Authors: Kahya Karaca Sinem , Hekimoğlu Canan
Published: July 2024

Tam dişsiz arkların dijital kaydı bilgisayar destekli tasarım/bilgisayar destekli üretim sistemleri ile diş hekimliği alanına girmiştir. Başlangıçta geleneksel yöntem ile alınan ölçüler indirekt yöntem ile dijital ortama aktarılmıştır. Dokuların direkt kaydını sağlayan ağız içi tarayıcılar ile indirekt yöntemde geleneksel ölçü aşamalarına bağlı hataların önüne geçmek amaçlanmıştır. Ayrıca ağız içi tarayıcılar ile işlem süresinin kısaltılması, hasta konforunun arttırılması, gerekli laboratuvar aşamalarının azaltılması gibi avantajlar elde edilmiştir. Ancak yine de kenar tıkamasını sağlayacak periferal dokuların hareketi, oral mukozanın net referans alanlar açısından yetersiz olması gibi zorluklar bulunur. Bu durum tarama sırasında ağız içi tarayıcının görüntü birleştirme algoritmasında hataya yol açabilir ve kaydın doğruluğunu olumsuz etkileyebilir. Bu nedenle tam dişsiz arkların direkt dijital kaydında ağız içi tarayıcıların rutin klinik kullanımı günümüzde hala mümkün değildir. Birçok araştırmacı tam dişsiz arklarda ağız içi tarayıcıların kullanımını geliştirmek için farklı tarama stratejileri, ekartasyon araçları ve teknikler geliştirmiştir. Bir diğer sorun ise dijital ark taramalarının çeneler arası ilişkiye uygun olarak hizalanamamasıdır. Bu aşama için mutlaka fiziksel bir kayıt alınması ve bu kaydın dijital ortama aktarılması gerekmektedir. Tüm bu veriler ışığında ağız içi tarayıcıların tam dişsiz arkların kaydında kullanımı umut verici olup, dijital sistemlerin hızla gelişimi ve yeni yöntemlerin geliştirilmesi ile yakın gelecekte bu konudaki birçok yetersizliğin ortadan kaldırılabileceği gerçeği kaçınılmazdır.
Anahtar Kelimeler: Tam Dişsizlik, Dijital Teknoloji, Dental Ölçü Teknikleri
APPROACHES TO DETERMINING THE GEOMETRIC PARAMETERS OF LIQUID DROPLETS USING DIGITAL IMAGE ANALYSIS
Authors: НАЗАРОВ Н.А. , БАРАНОВ И.Н. , МИСЬКИВ Н.Б. , СТАРИНСКАЯ Е.М.
Published: July 2024

В настоящее время актуальными задачами являются исследования в области спрейного охлаждения, взаимодействия капель со сложноструктурированными поверхностями, испарения капель различных жидкостей с твёрдой стенки и т. п. При проведении такого рода экспериментов, требующих записи большого количества видеоданных, ключевую роль играют методы автоматической обработки цифровых изображений. Предложены методы распознавания объекта на цифровом изображении для получения количественных характеристик испаряющихся капель в условиях недостаточного освещения. Разработаны новые алгоритмы выделения и замыкания границ объектов в условиях недостаточной видимости, с помощью которых выполнены измерения геометрических параметров испаряющихся капель. Проведено сравнение с данными, полученными методом ручной обработки изображений, продемонстрированы условия применимости предложенных алгоритмов.

Currently, ongoing tasks involve research in the field of spray cooling, droplet interaction with complex surfaces, and droplet evaporation from solid walls. Automated digital image processing methods are utilized to conduct these experiments, particularly when recording large amounts of video data. This paper presents methods for recognizing objects in digital images to obtain quantitative characteristics of evaporating droplets in low-light conditions. New algorithms have been developed to identify and close object boundaries under conditions of limited visibility, enabling measurement of the geometric parameters of evaporating droplets. A comparison is made with data obtained using the manual image processing method, and the conditions for the applicability of the proposed algorithms are demonstrated.
OBTAINING COMPOSITE MATERIALS OF THE SYSTEM Al – METALLIC GLASS Fe66Cr10Nb5B19, POSSESSING ANISOTROPY OF MECHANICAL PROPERTIES
Authors: КВАШНИН В.И. , НОВОСЕЛОВ А.Н. , ЛЕГАН М.А. , ЕСИКОВ М.А. , ГАВРИЛОВ А.И. , УХИНА А.В.
Published: July 2024

Описывается получение композиционных материалов с алюминиевой матрицей, содержащих частицы металлического стекла состава Fe66Cr10Nb5B19, путем последовательного применения механической активации исходных порошков в планетарной мельнице и электроискрового спекания. В ходе спекания при 540 °C происходит полное или частичное превращение частиц металлического стекла в интерметаллидное соединение Fe4Al13. Композиционные материалы, спеченные из смеси Al + 20 (об.) % Fe66Cr10Nb5B19, характеризуются анизотропией механических свойств: предел текучести при сжатии, микротвердость и деформация при разрушении в направлении прессования при спекании составляют 550 МПа, 200 HV и 14.2 % соответственно, в то время как в направлении, перпендикулярном направлению прессования, данные характеристики составляют 740 МПа, 250 HV и 2.2 %.

The paper describes the production of aluminum matrix composite materials containing metallic glass particles of the composition Fe66Cr10Nb5B19 by successively applying mechanical activation of the initial powders in a planetary mill and spark sintering. During sintering at 540 °C, the metallic glass particles are completely or partially converted into the intermetallic compound Fe4Al13. Composite materials sintered from a mixture of Al + 20 (vol.) % Fe66Cr10Nb5B19 are characterized by anisotropy of mechanical properties: the yield strength in compression, microhardness and deformation at failure in the pressing direction during sintering are 550 MPa, 200 HV and 14.2%, respectively, while in the direction perpendicular to the pressing direction, these characteristics are 740 MPa, 250 HV and 2.2%
Die ersten Professoren der Nationalen Medizinischen Universität Charkiw, Zöglinge der deutschen höheren medizinischen Schule: zum 220. Jahrestag der Universität (1804–2024)
Authors:   Nationale Medizinische Universität Charkiw, Kapustnyk V.A. , Pertseva J.N. ,   Nationale Medizinische Universität Charkiw, Olhovskyi V.A. ,   Nationale Medizinische Universität Charkiw, Trübner K. ,   Medizinische Universität Essen (Deutschland)
Published: July 2024

Der Artikel ist dem 220. Jahrestag der Nationalen Medizinischen Universität Charkiw und dem Beitrag der ersten Leiter der Abteilungen der Universität, insbesondere Professoren, Absolventen der damaligen Deutschen Hochschule für Medizin, bei der Gründung der Hochschule für Medizinische Hochschule Charkiw gewidmet. Schlüsselwörter: Geschichte der Medizin, Nationale Medizinische Universität Charkiw, deutsche Medizinprofessoren.
My memories of my father Volodymyr Viktorovich Bobin. To the 100th anniversary of the birthday
Authors: Bobina I.V.
Published: July 2024

The article presents not only official data about the professor of the Department of Normal Human Anatomy of the Kharkiv National Medical University, academician of the Ukrainian Academy of Sciences of National Progress, honorary academician of the International Academy of Integrative Anthropology, Doctor of Medical Sciences Volodymyr Viktorovych Bobin, but also the memories of his daughter Iryna. The portrait of a scientist, intellectual, teacher, loving son, father and grandfather, who was Professor V.V. Bobin, is shown. Key words: anatomy, anthropology, normal anatomy, history of medicine, medical dynasty, Volodymyr Bobin.
Outstanding graduates of the university of Kharkiv. To the centenary of the birth of professor Volodymyr Bobin
Authors:   V. N. Karazin Kharkiv National University, Sherstiuk S.O.
Published: July 2024

The School of Medicine of Kharkiv University is famous for its students. This faculty was home to outstanding pioneering scientists in many areas of medicine, who were also educators and humanists. The names of professors V.F. Grube, L.L. Hirschman, V.Y. Danilevsky, V.P. Vorobyov, and many others are widely known in the history of medicine and brought well-deserved fame to Kharkiv. This essay is dedicated to the Bobin doctors, who have been serving people and the cause of public health with their knowledge and medical work for over 160 years. Volodymyr Pavlovych Bobin (1858–1925) graduated from the Medical Faculty of Kharkiv University in 1881. In 1884, after working for the first years after graduation at the Department of General Pathology of Kharkiv University, he was elected as a medical administrator of the free hospital of the D.O. Donets-Zakharzhevsky Kharkiv Medical Society. In November 1884, Volodymyr Pavlovych was elected correcting physician-manager of the KMT hospital. Viktor Bobin was born in Kharkiv on March 28, 1890. His choice of profession was made consciously, and after graduating from high school, Viktor entered the medical faculty of Kharkiv University. From the very fist brilliant lectures of Professor V.P. Vorobyov, Bobin decided to study anatomy. For many years, Viktor Bobin headed the Crimean Society of Anatomists, Histologists and Embryologists and was a member of the Presidium of the Ukrainian Republican Society of AGE. The Bobin medical dynasty continues. The third representative of the Bobin’s dynasty is Volodymyr Viktorovych Bobin (1924–2016), son of Viktor Volodymyrovych. This year marks the 100th anniversary of the birth of Professor, Doctor of Medicine, Academician of the International Academy of Integrative Anthropology, Academician of the Ukrainian Academy of Sciences for National Progress, Head of the Department of Normal Anatomy at Kharkiv National Medical University (KhMU) in 1971–1992. A worthy representative of the Bobin’s medical dynasty, he taught many students of anatomy, wrote numerous textbooks for students, thoroughly researched the macromicroscopic anatomy of the nervous system, and made a significant contribution to science. Key words: Bobin, professor, doctor, Kharkiv University, Society of Anatomists.
Kyiv professor Kh. Ya. von Hubbenet (1821–1873): review of literature and main milestones of biography
Authors:   Independent scientist, Ukraine, Vasyliev Kostyantyn , Pozemkovska Maija ,   Riga Stradins University, Latvia, Vasyliev Yurii ,   Sumy State University, Ukraine
Published: July 2024

The article provides an analysis of the literature about prof. Gübbenet, who allowed the entire historiography of the issue to be compiled into four groups and the most informative works to be identified. A number of facts and dates of Kh.Ya. Hubbenet’s biography have been clarified. For the first time, its iconography has been studied and a description of the burial of the Gübbenet family in the Liepupe cemetery in Latvia is given. Key words: surgery, public health, Kyiv University, Ukraine.
Graduates of the German higher medical school in the origins Kharkiv National Medical University: to the 220th anniversary of the university’s founding (1804–2024)
Authors:   Kharkiv National Medical University, Kapustnyk V.A. , Pertseva Zh.M. ,   Kharkiv National Medical University, Olkhovsky V.O. ,   Kharkiv National Medical University, Trübner Kurt ,   Medical University of Essen (Germany)
Published: July 2024

The article is devoted to the 220th anniversary of the Kharkiv National Medical University and the contribution of the first heads of the university’s departments, in particular professors, graduates of the German Higher Medical School of that time, in the formation of the Kharkiv Higher Medical School. Key words: History of medicine, Kharkiv National Medical University, German medical professors.
Effect of revascularization of coronary arteries on mechanical dyssynchrony of left ventricular myocardium in patients with coronary heart disease
Authors:   V.N. Karazin Kharkiv National University, Mehtieva Fatma , Bilchenko O.V. ,   Kharkiv National Medical University.
Published: July 2024

Introduction. Defining a treatment strategy for patients with stable coronary heart disease will require the development of personalized criteria, among which the assessment of myocardial dyssynchrony is considered promising. The aim of the study was to evaluate the effect of revascularization of coronary arteries on indicators of mechanical myocardial dyssynchrony in patients with stable coronary heart disease. Materials and methods. The study included 121 patients with coronary heart disease, who were assessed for mechanical myocardial dyssynchrony before and 2 weeks after revascularization. The main group included 48 patients with myocardial dyssynchrony, and the comparison group included 73 patients without myocardial dyssynchrony. Complete occlusion and lesions of 3 coronary arteries were found more often in the group with myocardial dyssynchrony, and the main group also had a higher SYNTAX SCORE. The results. Mechanical dyssynchrony of the myocardium was found in 39% of patients with coronary heart disease. Before revascularization, a signifiant increase in SPWMD, APEI, IVMD, and a decrease in LVFT and LVET were found in the group of patients with myocardial dyssynchrony. After revascularization in the main group, in 9 patients out of 48 (18.7%), indicators of myocardial dyssynchrony returned to normal values. LVFT in the group of patients with myocardial dyssynchrony significantly increased, as well as left ventricular ejection time (LVET) (from 318.5±9.6 ms to 344.9±23.2 ms, p<0.01). Conclusions. After revascularization, the number of patients with myocardial dyssynchrony significantly decreased due to the improvement of interventricular and intraventricular dyssynchrony indicators. Key words: myocardial dyssynchrony, coronary heart disease, revascularization, coronary angiography, SYNTAX SCORE.
About strategy development of the national health care system of Ukraine
Authors:   Kharkiv National Medical Univercity, Serdiuk O. , Rogozhyn B. ,   Kharkiv National Medical University, Fedchenko Yu. ,   Kharkiv National Medical Univercity, Danno V. ,   Public Organization «International Medical Cluster», Kharkiv
Published: July 2024

A study of the directions of strategic development of the National Health Service of Ukraine, in accordance with the tasks of the program documents of the WHO, in modern wartime conditions, was conducted. The need to organize PMD in Ukraine in accordance with the practice of EU countries is substantiated. It has been proven that the economic availability of medical care in Ukraine should aim at generally recognized indicators of EU countries. It was determined that the system of guaranteeing quality and ensuring the efficiency of the provision of medical care is made up National protocols and National standards for providing medical care. The strategy for organizing the work of the National Health Service of Ukraine in wartime conditions needs to be worked out. Cooperation with the public sector regarding the development of the NHS of Ukraine should be carried out taking into account the practice of EU countries and the recommendations of the WHO European Bureau. Key words: health care, strategy, accessibility, quality
The manifestation of addictive behavior among Seventh-day Adventist believers in the conditions of war in Ukraine
Authors:   Ukrainian Institute of Arts and Sciences, Bucha, Ukraine, Kuryliak V.V. , Butkevich V.V. ,   Interregional Academy of Personnel Management, Kyiv, Ukraine
Published: July 2024

The study is dedicated to analyzing addictive behavior among members of the Seventh-day Adventist Church in the context of war in Ukraine. The paper establishes a connection between religious identity and survival strategies in conflict conditions, and also examines the role of church practices in overcoming addictions. Specifically, it explores how religious beliefs can prevent or, conversely, contribute to the development of addictions, what forms of addictive behavior are typical for this religious group during war, and how psychosocial support from the church community can influence the overcoming of stress and anxiety. The research findings show that Adventists have certain advantages in managing addictive behavior during war, but they are also susceptible to the influence of stress and traumatic events. In conclusion, the paper proposes practical measures aimed at protecting believers of this denomination from addictions, particularly through maintaining a healthy lifestyle and active support from spiritual leadership and the community. Special attention is paid to the strategies Adventists use to overcome stress and maintain psychological balance. This study contributes to a deeper understanding of the mechanisms through which war affects the manifestation of addictive behavior and is important for developing strategies of mental support for Christian believers in conditions of prolonged conflict. Key words: addictive behavior, believers, Seventh-day Adventist Church, war, Ukraine.
Positive and negative aspects of adaptation of Primary School Students to War conditions in Ukraine
Authors:   Ukrainian Institute of Arts and Sciences, Bucha, Ukraine, Mierienkov H.A. , Oliniychuk L.A. ,   Interregional Academy of Personnel Management, Kyiv, Ukraine
Published: July 2024

The adaptation of schoolchildren to the conditions of the war in Ukraine is an extremely difficult task that requires a comprehensive approach and close monitoring by educational and psychological specialists. Military conflicts and threats can create severe stress and anxiety among children, which can affect their ability to learn and social adjustment. First of all, it is important to ensure safety and psychological comfort for students. This may include training and information activities for children, talking to them about their feelings and coping with stress, and providing access to psychological support. It is important to create favorable conditions for learning, even in uncertain times. This may mean the development of psychological rehabilitation programs, the use of innovative teaching methods that allow children to feel safe and focus on learning. Equally important is the support of parents and teachers in providing children with the necessary resources and psychological support. Teachers can be trained to respond to difficult situations and be able to help students cope effectively with stress. Parents can also be included in the process, receiving advice and support from the school and child psychologists. Key words: formation, habits, adaptation, elementary school, conditions of war, Ukraine, light, shelling
Diabetes mellitus 2: organization of prevention and rehabilitation
Authors:   Kharkiv National Medical Univercity, Serdyuk O.I. , Rohozhyn B.A. ,   Kharkiv National Medical University, Oparin A.G. ,   Kharkiv National Medical Univercity, Prosolenko N.V. ,   Kharkiv National Medical University, Krupenya V.I. ,   Kharkiv National Medical Univercity, Sikalo Yu.K. ,   Kharkiv National Medical University
Published: July 2024

The problems of organizing the implementation of the provisions of the Unified clinical protocol Diabetes mellitus 2 (UCP DM2) in the national health care system of Ukraine were studied. It has been proven that the primary level of medical care is unable to perform the functions of ensuring the organization and providing rehabilitation and preventive care. It has been established that sanatorium-resort facilities have experience, resource and technological support for the implementation of T2DM prevention and rehabilitation tasks. Аnd organizational scheme of rehabilitation and prevention for patients with T2DM is proposed. Key words: diabetes mellitus type 2, rehabilitation, prevention, organization of care.
Comorbidity of patients with chronic non-infectious diseases in the practice of a family doctor
Authors:   Kharkiv National Medical Univercity, Korzh O.M.
Published: July 2024

Comorbidity is a serious problem of public health and health care around the world due to its growth in various population groups due to the improvement of socio-economic conditions, changes in lifestyle, expansion of diagnostic capabilities of health care services, as well as in connection with the aging of the population. Chronic somatic diseases and psycho-emotional disorders can develop independently or be interconnected at different stages of their formation and progression. Research interest in studying the interactions between chronic diseases and psychoemotional disorders, primarily depression and anxiety, has increased significantly in recent years, given their high prevalence in individuals with at least one chronic disease compared to those without any disease. Key words: comorbidity, chronic non-infectious diseases, family doctor.
The role of endogenous ligands and biogenic amines in the development of the comorbid course of gastroesophageal reflx disease and chronic obstructive pulmonary inflmmation
Authors:   Kharkiv National Medical University, Oparin O.A. , Blagoveshchenska A.V. ,   Kharkiv National Medical University, Khomenko L.O. ,   Kharkiv National Medical University, Semenova N.V. ,   Kharkiv National Medical University, Novokhatnia A.E. ,   Kharkiv National Medical University, Oparina T.M. ,   Kharkiv National Medical University, Korenovsky I.P. ,   Kharkiv National Medical University
Published: July 2024

The paper analyzes the role of endogenous ligands and biogenic amines in the development of the comorbid course of gastroesophageal reflux disease and chronic obstructive pulmonary inflammation. It is shown that the study of the role of inflammation in the development of GERD and COPD led to a new perspective on the mechanisms of damage to target organs in the isolated course of these diseases. This makes it possible to approach from new positions, both the formation of therapy schemes and the development of preventive measures. Key words: gastroesophageal reflux disease, chronic obstructive pulmonary inflammation, pathogenesis, apelin, norepinephrine.
Early Childhood Care Coordination Through 211: A Randomized Clinical Trial
Authors: Nelson Bergen B. , Dudovitz Rebecca N. , Thompson Lindsey R. , Vangala Sitaram , Zevallos-Roberts Emilia , Gulsrud Amanda , Porras-Javier Lorena , Romley John A. , Herrera Patricia , Aceves Irene , Chung Paul J.
Published: July 2024

BACKGROUND AND OBJECTIVES

Early intervention services can improve outcomes for children with developmental delays. Health care providers, however, often struggle to ensure timely referrals and services. We tested the effectiveness of telephone-based early childhood developmental care coordination through 211 LA, a health and human services call center serving Los Angeles County, in increasing referral and enrollment in services.

METHODS

In partnership with 4 clinic systems, we recruited and randomly assigned children aged 12 to 42 months with upcoming well-child visits and without a known developmental delay, to intervention versus usual care. All children received developmental screening and usual clinic care. Intervention children also received telephone connection to a 211 LA early childhood care coordinator who made referrals and conducted follow-up. Primary outcomes at a 6-month follow-up included parent-reported referral and enrollment in developmental services. Secondary outcomes included referral and enrollment in early care and education (ECE). Logistic regression models were used to estimate the odds of outcomes, adjusted for key covariates.

RESULTS

Of 565 families (282 intervention, 283 control), 512 (90.6%) provided follow-up data. Among all participants, more intervention than control children were referred to (25% vs 16%, adjusted odds ratio [AOR] 2.25, P = .003) and enrolled in (15% vs 9%, AOR 2.35, P = .008) ≥1 service, and more intervention than control children were referred to (58% vs 15%, AOR 9.06, P < .001) and enrolled in (26% vs 10%, AOR 3.75, P < .001) ECE.

CONCLUSIONS

Telephone-based care coordination through 211 LA is effective in connecting young children to developmental services and ECE, offering a potentially scalable solution for gaps and disparities.
Project Spotlight: Precast concrete replaces cast stone at Boston College
Authors: Fister Gale Sarah
Published: July 2024

Canadian precast concrete designer Béton Préfabriqué du Lac (BPDL) was brought in to help restore St. Mary’s Hall, the second building constructed on the Boston College campus, to its original glory. The facade of this sweeping gothic structure features graceful arches and intricate detailing replete with bas-relief panels and busts that reflect the traditional architectural style of the campus.
Two-year training program-induced cardiorespiratory developments in adolescent female handball players: The importance of playing position
Authors: Béres B. , Györe I. , Pálinkás G. , Szabó T. , Drenjančević I. , Koller A.
Published: July 2024

As there are few data available, we aimed to assess the development of the cardiorespiratory system of young female athletes following a two-year training program (2y-TP) and explore the game position-specific changes.

Methods

Before and after the 2y-TP body compositions of young elite female handball players (age: 14.2 ± 0.5 years, n = 33) were investigated by dual-energy x-ray absorptiometry (DEXA). The morphological changes of the heart were assessed by echocardiography, and cardiorespiratory values were investigated by spiroergometry.

Results

Compared to initial values, after the 2y-TP, significant increases were found in body mass (by 8.8%), skeletal muscle mass (by 7.7%), and body fat (by 11.3%), power (by 7.8%), VO2 (by 10.6%), VCO2 (by 8.3%), oxygen pulse (by 13.8%), ventilation (by 13.4%), tidal volume (by 13.7%), left ventricular mass (by 24.8%), stroke volume (by 21.2%), and stroke volume normalized to the body surface (by 16.4%). Heart rate decreased (by 2.9%), whereas respiratory frequency, load time, relative power, and relative VO2 did not change. During the test, the goalkeepers run for a shorter time than the wing players at the initial time point and after the 2y-TP. Also, the maximum heart rate did not change in goalkeepers, whereas it decreased in wing players after the 2y-TP. Thus, the goalkeepers had a higher initial VO2 value at VO2peak than wing players, and differences, which were maintained after the 2y-TP, as well. In contrast, in goalkeepers, the relative VO2 at the VO2peak was initially lower than in wing players, which remained lower after the 2y-TP, as well.

Conclusions

In adolescent female handball players, the 2y-TP significantly improved skeletal muscle mass, which corresponded to significant improvements of cardiorespiratory function, which were more accentuated in wing players, compared to goalkeepers, likely due to the different loads during trainings and matches.
The predominance of sustainability perspectives in sports – A bibliometric analysis
Authors: Boros Anita , Tőzsér Dávid , Géczi Gábor
Published: July 2024

In the last decade, sustainability has become a keyword that must be addressed in any environment, society, or economy segment. Therefore, the relevance of sustainable operation and behaviour in complexly interrelated fields like sports is particularly actual. This study was designed to evaluate the demonstration of sports sustainability in the relevant literature by bibliometric analysis. The yearly number of publications, core topics, Sustainable Development Goal (SDG)-connection, author and affiliation patterns, most relevant journals, and terms and keywords were studied to thoroughly overview the trends. It was found that the number of papers is increasing, however, with a slight setback in the last few years. The main topics relate to several environmental, economic (social), governmental (ESG) segments, but the listed publications need more SDG connections. A high proportion of fundamental papers from the research area are from authors affiliated with a narrow group of countries, and one journal published relatively far the most articles. The most relevant keywords are sustainability, physical activity, and sport, while the primary topic hot spots can be classified into four clusters. In conclusion, more in-depth publications are required to reveal the underrepresented field of sports sustainability in the literature, which should simultaneously incorporate the environmental, social, and economic aspects. This would foster better understanding, public awareness, and the spread of best practices in theory and practice, which could be implemented as an attitude-formation tool.
Whiplash-associated disorders: A case report
Authors: Battal Grace , Hanna-Boutros Berthe
Published: July 2024

Approximately 50% of people who suffer from whiplash enter the chronic phase of this condition and develop persistent symptoms known as chronic whiplash-associated disorders (WAD). This case study aims to contribute to the understanding of rehabilitation programmes combining cervical exercises and proprioceptive training for managing such conditions, as the literature supporting their significance is inconclusive. A 29-year-old female with chronic WAD was evaluated using goniometry, the visual analog scale (VAS), and the neck disability index (NDI). She displayed reduced neck mobility, local neck pain associated with cervicogenic headache, and neck-related disability. The intervention lasted 6 weeks, involving two 40 min weekly sessions. The exercise programme incorporated cervical spine-specific exercises, including range of motion, postural endurance, and muscle strengthening, as well as sensorimotor exercises targeting kinaesthetic sense, eye movement control, and eye-head coordination. The outcome measures reflected the resolution of symptoms and physical impairments. The patient experienced significant improvements in cervical mobility, as she regained a full range of movement in all planes. The patient also demonstrated amelioration in both pain and cervical function states. The VAS score dropped from 6/10 to 2/10; likewise, the NDI score decreased from 58% to 22% at the end of the treatment. Our observations suggest that a rehabilitation programme retraining both the cervical musculature and sensorimotor control may be effective in reducing pain and disability in people with chronic WAD. Further research is required to determine the optimal exercise programme for managing symptoms chronicity in people with WAD.
EVALUATION OF THE EFFICACY OF ASPARAGINASE ADDED TO CHEMOTHERAPEUTIC DRUG REGIMEN IN ACUTE LYMPHOBLASTIC LEUKEMIA BY MINIMAL RESIDUAL DISEASE MEASUREMENT
Authors: Akpınar Oktar Pınar , Güneş Merve , Kılıç Rumeysa , Yıldırım Gülşen , Yurtsever Sarıca Deniz , Taşdelen Serpil , Patiroğlu Türkan , Ezer Üstün , Kürekci A. Emin
Published: July 2024

B-ALL is the most common subtype of childhood Acute Lymphoblastic Leukemia (ALL), affecting approximately 85% of children worldwide. Minimal Residual Disease (MRD) monitoring during treatment of ALL is important for the prognosis of the disease. MRD monitoring, which enables early detection of relapse, determination of risk percentage and understanding the effectiveness of treatment, can be performed with multiple methods such as flow cytometry, qRT-PCR and NGS. Asparaginase is an enzyme that has been used in the treatment of ALL since the 1960s, converting asparagine to ammonia and aspartic acid, lowering serum asparagine levels and causing the death of malignant cells. In this study, we investigated the effect of asparaginase added to the ALL IC BFM 2009 treatment protocol in 62 B-ALL patients aged 0-18 years with MRD monitoring by flow cytometry. In our study, Escherichia Coli (E.Coli.) asparaginase was used primarily and PEG-asparaginase was used after allergy development. The effect of asparaginase on treatment was evaluated by evaluating asparagine concentration and asparaginase activity measured at TP1 (4th week after induction treatment) together with MRD levels. As a result of the study, it was observed that the added asparaginase positively affected the treatment and increased the negativity in MRD levels.
Uso da tecnologia blockchain nas contratações públicas sustentáveis de obras rodoviárias
Authors: Giamberardino Guilherme Gonçalves , Gadda Tatiana Maria Cecy , Nagalli André
Published: July 2024

Resumo A dificuldade de incorporar a variável ambiental nos processos de contratação é recorrente no mundo. Nesse contexto, as contratações públicas sustentáveis são um instrumento importante para reduzir o impacto ambiental das organizações. No Brasil, há incapacidade para incorporar instrumentos que permitam uma atividade pública mais eficaz e eficiente. Em contrapartida, as tecnologias digitais, como a blockchain, podem ser a solução para problemas complexos no setor público. Nos últimos anos, governos têm adotado a blockchain em diversas áreas, sendo que, no âmbito internacional, a tecnologia é utilizada em bancos de dados de alguns países. No sentido de facilitar a implantação dos critérios ambientais nos procedimentos de licitação, este estudo propõe um modelo conceitual de aplicação da blockchain para contratações públicas sustentáveis de obras rodoviárias. Com base na análise de conteúdo de 25 processos de licitação, foi realizado o mapeamento das principais atividades, o que permitiu propor uma solução integrada ao Portal Nacional de Contratações Públicas. A principal contribuição do estudo é apresentar as potenciais aplicações referentes aos aspectos ambientais para blockchain nas contratações públicas e demonstrar a viabilidade da implementação dessa tecnologia. Diante das novas perspectivas para otimizar a gestão dos processos licitatórios e prover a sustentabilidade ambiental na administração pública, entende-se que a blockchain pode auxiliar na promoção de uma estrutura de licitação confiável, descentralizada, transparente e ambientalmente sustentável.
Escala de habilidades para gerenciar o teletrabalho em casa (EHGTC)
Authors: Miranda Lisa Ferreira de , Martins Lara Barros , Abbad Gardênia da Silva , Legentil Juliana , Mourão Luciana
Published: July 2024

Resumo Este estudo desenvolveu e testou a validade de uma escala que mede as habilidades para gerir o trabalho desde casa, como: relatar mudanças, buscar informações, definir prioridades, definir e adaptar metas, avaliar os resultados do trabalho, distribuir tarefas e fornecer feedback. Participaram 2.038 gestores de três organizações públicas brasileiras. As análises fatoriais exploratórias, confirmatórias e multigrupo revelaram uma estrutura unifatorial de oito itens, excelentes índices de confiabilidade e qualidade de ajuste, bem como invariância para gênero e faixas etárias. A escala curta permite testar modelos de pesquisa com múltiplas variáveis, estudos comparativos (teletrabalho voluntário versus compulsório) e estudos interculturais.
Determinants of compliance with personnel expenses and primary result in Brazilian States: an analysis from 2017 to 2022
Authors: Lima Cristiana Aragão Marques Correia , Boente Diego Rodrigues , Stefanelli Nelson Oliveira
Published: July 2024

Abstract This scientific article evaluates the determinants of fiscal management represented by compliance with the thresholds of the Fiscal Responsibility Law and the primary result target. The study adopted an econometric approach, using binary variables regarding the Brazilian states’ compliance with the total personnel expenditure target and the primary result target. Social and accounting data and the manager’s characteristics were used to analyze the determining factors. In addition, a multiple regression analysis for panel data was conducted, examining the period from 2017 to 2022. In the model for total personnel expenditure, transfers from the federal government to the states and tax revenue favor non-compliance with the thresholds of the Fiscal Responsibility Law. On the other hand, for the primary result target, transfers, accounts payable, payment capacity, and the managers’ education level and age favor compliance with the target.
A influência de aspectos organizacionais das instituições de ensino e pesquisa sobre os custos de transação na formação de parcerias com governos locais
Authors: Palotti Pedro Lucas de Moura , Joppert Marcia Paterno , Machado José Angelo
Published: July 2024

Resumo De que forma aspectos organizacionais das instituições de ensino e pesquisa influenciam os custos de transação para efetivação de parcerias com administrações locais? Com base em dados inéditos de um survey online para o conjunto de 95 instituições de ensino, com respostas validadas, o presente artigo se propôs a responder a essa pergunta por meio de um estudo quantitativo buscando verificar a correlação entre características das parcerias firmadas e três aspectos organizacionais selecionados: a descentralização dos campi; existência de estrutura de acolhimento de potenciais parceiros (porta de entrada); e existência de instâncias de aprovação. Com base em proposições relativas aos custos de transação, extraídas da teoria da ação institucional coletiva, foram formuladas hipóteses envolvendo o efeito de cada aspecto organizacional. Os resultados apontaram, ao final, que a descentralização dos campi influencia não apenas na presença como também no número de experiências relevantes de parcerias com municípios. Já a estruturação de “portas de entrada” nas instituições de formação afeta mais especificamente o grau de formalização das parcerias, oferecendo maior segurança jurídica e estabilidade. A presença de instâncias de aprovação para as parcerias negociadas nas instituições de ensino e pesquisa parece não afetar, em sentido positivo ou negativo, a firmação dessas parcerias.
The influence of organizational aspects of educational and research institutions on transaction costs in the formation of partnerships with local governments
Authors: Palotti Pedro Lucas de Moura , Joppert Marcia Paterno , Machado José Angelo
Published: July 2024

Abstract How do organizational aspects of education and research institutions influence transaction costs in establishing partnerships with local administrations? Based on unpublished data from an online survey of a group of 95 educational institutions this article aims to answer this question through a quantitative study seeking to verify the correlation between the characteristics of the partnerships formed and three selected organizational aspects: decentralization of campuses, the existence of a structure to welcome potential partners (gateway), and the presence of approval bodies. Based on propositions relating to transaction costs extracted from the theory of collective institutional action, hypotheses were formulated involving the effect of each organizational aspect. The results showed that the decentralization of campuses influences not only the presence but also the number of relevant experiences of partnerships with municipalities. Structuring “gateways” in training institutions more precisely affects the degree of formalization of partnerships, offering greater legal security and stability. However, the presence of approval bodies for partnerships negotiated in teaching and research institutions does not seem to affect, either positively or negatively, the establishment of these partnerships.
Association between cortisol levels and performance in clinical simulation: a systematic review
Authors: Teixeira Jackson Gois , Lima Lucas Tomaz Benigno , Cunha Elaine Carvalho , Marques da Cruz Flavia Oliveira de Almeida , Carneiro Karen Karoline Gouveia , Ribeiro Laiane Medeiros , Brasil Guilherme da Costa
Published: July 2024

ABSTRACT Objective: To identify how stress measured by salivary cortisol during clinical simulation-based education, or simulation and another teaching method, impacts performance. Method: Systematic review of the association between cortisol and performance in simulations. The following databases were used: PubMed, LIVIVO, Scopus, EMBASE, Latin American and Caribbean Health Sciences Literature (LILACS) and Web of Science. Additional searches of gray literature were carried out on Google Scholar and Proquest. The searches took place on March 20, 2023. The risk of bias of randomized clinical trials was assessed using the Cochrane Collaboration Risk of Bias Tool (RoB 2). Inclusion criteria were: simulation studies with salivary cortisol collection and performance evaluation, published in any period in Portuguese, English and Spanish. Results: 11 studies were included which measured stress using salivary cortisol and were analyzed using descriptive synthesis and qualitative analysis. Conclusion: Some studies have shown a relationship between stress and performance, which may be beneficial or harmful to the participant. However, other studies did not show this correlation, which may not have been due to methodological issues.
DEVELOPMENT AND VALIDITY OF AN ALGORITHM FOR PLANNING INTRAVENOUS MEDICATION ADMINISTRATION IN INFANTS
Authors: Costa Anna Caroline Leite , Mendes Léia Arcanjo , Santos Luciano Marques dos , Marcatto Juliana De Oliveira , Corrêa Allana dos Reis , Kusahara Denise Miyuki , Manzo Bruna Figueiredo
Published: July 2024

ABSTRACT Objective: to develop and validate the content of an algorithm for planning intravenous medication administration in infants. Method: this is a methodological study of technology development and validity. A scoping review was carried out, which supported the creation of an algorithm by the researchers and its subsequent validity by 13 expert nurses, which took place between November 2021 and March 2022. Items with a Content Validity Index ≥ 0.8 were considered acceptable. Results: thirty-one references were included in the scoping review, organized into five categories: “recommendation for intravenous access”, “polypharmacy-related care”, “care prior to intravenous medication administration”, “venous catheter handling-related care” and “medication infusion-related care”. This division supported the algorithm development, which was validated after three rounds, with an overall Content Validity Index of the instrument of 0.91. Conclusion: algorithm validity indicates reliability and accuracy of its content.