bluuebunny/crossref_metadata_2025 huggingface dataset:
Weighted Gene Co-expression Network Analysis Identifies a Cancer-Associated Fibroblasts Signature for Predicting Prognosis and Immunotherapeutic Responses in Skin Cutaneous Melanoma
Authors: Liu Jinhua , Han Jingjing , Yang Zheng , Hou Yinglong , Wang Qiying
Published: September 2023

Objective: Cancer-associated fibroblasts (CAFs) are the most prominent cellular component in the stroma of skin cutaneous melanoma (SKCM). The aim of this study was to explore the CAFs-related genes and to develop a CAFs-related model to predict the prognosis and immunotherapeutic efficacy of SKCM.
Method: We collected mRNA expression and clinical information for 449 SKCM patients from the TCGA (The Cancer Genome Atlas) database and 210 patients in the GSE65904 dataset of the GEO (Gene expression Omnibus) database. CAFs infiltrations were quantified by the estimate the proportion of immune and cancer cells (EPIC) method. Weighted gene coexpression network analysis (WGCNA) was used to identify genes CAFs-related genes. A CAFs risk signature was then developed using the univariate and least absolute shrinkage and selection operator method (LASSO) Cox regression model. Gene set enrichment analysis (GSEA) and single sample gene set enrichment analysis (ssGSEA) were applied to elucidate the molecular mechanisms. The tumor immune dysfunction and exclusion (TIDE) algorithm is further used to assess immunotherapeutic responses.
Results: A six-gene (NOTCH3, HEYL, BGN, COL5A1, SULF1, COL1A1) CAFs prediction model was constructed. SKCM patients were divided into high– and low–CAFs-risk groups according to the median CAFs risk score. patients in the CAFs high-risk group had a significantly worse prognosis. GSEA showed that the ECM receptor-interacting and basal cell oncogene set was highly and significantly enriched in the high–CAFs-risk group. The ssGSEA results showed that CAFs risk scores were significantly positively correlated with basal cell carcinoma, melanogenesis and Notch signaling pathways, and significantly negatively correlated with regulation of autophagy and Toll-like receptor signaling pathways. ssGSEA results also showed that patients in the high–CAFs-risk group had a poorer response to immunotherapy.
Conclusion: The six CAFs signature genes explored in this study not only reliably predicted prognosis, but also assessed clinical immunotherapy response in SKCM patients, which may have important clinical implications for tailoring anti-CAFs therapy and immunotherapy regimen for each SKCM patient.
Comparative analysis of bacterial diversity of pond water with different output of Chinese soft-shelled turtle Pelodiscus sinensis in dark greenhouse mode
Authors: Wang Yaguang , Chang Xiao , Yan Baoguo , Zhang Huijuan , Guan Yueqiang
Published: September 2023

Dark greenhouse culture is one of the main culture methods of the Chinese soft-shelled turtle, Pelodiscus sinensis. The present study found that the outputs of P. sinensis differed among five ponds with the same initial stocking density and management measures, with the output of pond B with maximum yield being 1.69 times higher than that of pond A with minimum yield. Therefore, the physicochemical factors and bacterial communities of the two ponds were monitored, analyzed and compared. The contents of total nitrogen, nitrite nitrogen, and dissolved oxygen in pond B were extremely significantly higher than those in pond A at the late stage of cultivation. Correspondingly, the microbial diversity and richness were also higher in pond B. Additionally, the higher relative abundances of Gemmatimonadetes, Firmicutes, Nitrosomonas, Saccharimonadales andAzospira in pond B conferred it higher nitrification and denitrification ability than pond A in the middle and late stage of cultivation. Pearson’s correlation coefficient showed that the Saccharimonadales andAzospira were correlated with total nitrogen, ammonia nitrogen, nitrite nitrogen, and nitrate nitrogen. Our results provide a reference for the modulation of the water environment in the dark greenhouse mode that used for turtle cultivation.
Hypertension and gout: A Mendelian randomization study
Authors: yanfang li , Xie Yufeng , Li Jun , Chang Zhichun , Zhang Jianmei , Zhou Zunming , Ren Rong , Chen Yun
Published: September 2023

Background: Although there is solid epidemiological evidence supporting the connection between hypertension and gout, the causal relationship and direction associated are uncertain, so we aim to research the causal relationship between hypertension and gout.
Methods: We conducted a two-sample Mendelian randomization (MR) analysis to assess the causal effect between hypertension (including diastolic blood pressure and systolic blood pressure) and gout (including gout, drug-induced gout, idiopathic gout, unspecified gout, and strictly defined gout) using genome-wide association study statistics. The inverse variance weighting method was used to generate the main results, while sensitivity analyses using MR-Egger, weighted median, Cochran’s Q test, Egger intercept test, and leave-one-out analysis, were performed to assess the stability and reliability of the results.
Results: After the screening, we found a causal relationship between diastolic blood pressure and gout, idiopathic gout, unspecified gout, and strictly defined gout, and a causal relationship between systolic blood pressure and gout, idiopathic gout, unspecified gout, and strictly defined gout.
Conclusion: It is indicated that the control of hypertension may reduce the risk of gout.
Prevalence of Depression and Anxiety in Syrian Patients with Ankylosing Spondylitis: Associations with Disease-Related Factors, Fatigue, Quality of Life, and Sleep Disturbance - A Cross-Sectional Study
Authors: Safiah Mhd Homam , Ashabi Khaled Kalalib Al , Haj-Abow Tasnim , Alchallah Mhd Obai , Khalayli Naram , Kudsi Maysoun
Published: September 2023

Background
AS Patients are a vulnerable group to mood disorders due to the high burden of their disease and its impact on physical function and quality of life. Identifying risk factors for depression and anxiety is essential for at-risk groups to better outcomes. This study aims to assess the prevalence of depression and anxiety among Syrian AS patients and identify predictive factors.
Methods
This cross-sectional study was conducted using convenience sampling at the biological treatment unit of the rheumatology department in Damascus Hospital. Data were collected from face-to-face interviews with patients using validated structural questionnaires which included socio-demographics, disease characteristics variables, and different measures in order to assess disease activity (ASDAS, BASDAI), physical function and general health (BASFI, BASG), fatigue (FACIT Fatigue Scale), quality of life (ASQoL), depression (PHQ-9), anxiety (GAD-7), and sleep disturbance (JSS). A multiple linear regression model was used to investigate potentially predictive factors for depression and anxiety.
Results
Out of 103 patients, the majority were male 82 (79.6%), 40 (38.8%) quitted working due to disease, and 25 (24.3%) had a positive history of both depression and anxiety. 51 (49.5%) of patients showed clinically significant depression while clinically significant anxiety was identified by 38 (36.9%) of patients. Contextual and disease-related factors associated with depression and anxiety were quitting work due to disease, hip pain, and a positive history of mental distress. Disease activity scores were associated with both depression and anxiety but with low explanatory power. Significant association with relatively high explanatory power demonstrated between both depression and anxiety with poor quality of life, sever fatigue, and high frequency of sleep disturbance.
Conclusion
This study demonstrates high levels of depression and anxiety among Syrian AS patients, along with a high frequency of fatigue and sleep disturbance. Poor Quality of life, sever fatigue, and high frequency sleep disturbance are considered major predictive factors for depression and anxiety. Healthcare providers should pay more attention to depressive and anxiety symptoms in the course of AS patient management.
Genome-wide identification of the cation/proton antiporter (CPA) gene family and functional characterization of the key member BnaA05.NHX2 in allotetraploid rapeseed
Authors: Yue Cai-peng , Han Liao , Sun Si-si , Chen Jun-fan , Feng Ying-na , Huang Jing-yong , Zhou Ting , Hua Ying-peng
Published: September 2023

Rapeseed (Brassica napus L.) is susceptible to nutrient stresses during growth and development. So far, the CPA (cation proton antiporter) family genes have not been identified in B. napus and their biological functions are still unclear. Integrated analyses were conducted to identify the molecular characteristics of rapeseed CPAs and their responses to nutrient stresses. Through bioinformatics analysis, 117 BnaCPAs were identified at the genome-wide level, and they were divided into three subfamilies: Na+/H+ antiporter (NHX), K+ efflux antiporter (KEA), and cation/H+ antiporter (CHX). Transcriptomic profiling results showed that some BnaCPAs had various expression levels under different nutrient stresses especially under salt stress. Most members of the BnaNHX family showed a tendency of expression under different nutrient stress. The BnaNHX subfamily may be an important member of the BnaCPA family in regulating nutrient stress, especially in salt stress. We found that the salt tolerance of the transgenic overexpressed line constructed with BnaA05.NHX2 was significantly higher than that of the wild species Westar. Subcellular localization showed that BnaA05.NHX2 was localized on the tonoplast, and TEM combined with X-ray energy spectrum analysis revealed that the vacuolar Na+ concentrations of the BnaA05.NHX2-overexpressing rapeseed plants were significantly higher than those of wild type. According to our results, we provide insights into the complexity of the BnaCPA gene family and a valuable resource to explore the potential functions of BnaCPA genes in Brassica napus.
Chemical Composition, Allelopathic Potential, and Antimicrobial and Anticholinesterase Activity of Citrus sinensis (L.) Peel Oil
Authors: Silva Vítor Hugo Neves da , Trindade Ívina Thayná Miranda , Vicente Mayanna Emília Tenório , de Souza Geovania Santos , Maia Paulo José Sousa , Ávila Maiara de Souza Nunes , Silva Ingrid Reis da , de Lima Bruna Ribeiro , Carmo Dominique Fernandes de Moura do
Published: September 2023

Citrus sinensis is renowned for its notable biological effects. This research aimed to characterize the chemical composition of oil derived from the peel of Citrus sinensis (L.), referred to as CsPO, and to assess its antimicrobial efficacy against strains of Enterococcus faecalis (ATCC29212), Escherichia coli (ATCC25922), Candida albicans (ATCC10231), and Mycobacterium smegmatis (ATCC14468). Additionally, the investigation sought to analyze its impact on the growth of butter bean (Phaseolus lunatus) radicles, evaluate its inhibitory effects on acetylcholinesterase enzyme (AChE) both in vitro and in silico through molecular docking simulations, and determine its potential phytotoxicity. The analysis of the CsPO composition using gas chromatography coupled with mass spectrometry (GC-MS) identified thirty-three (33) monoterpene and sesquiterpene compounds, e.g., β-citronelene (7.33%), β-pinene (9.63%), car-3-en-2-one (8.43%), eugenol (4.24%), limonene-10-ol (8.26%), α-humulene (10.52%), α-neo-clovene (4.83%), and β-acoradiene (12.47%). CsPO demonstrated varying levels of antimicrobial activity, ranging from low (+) to moderate (++). In the allelopathy assay, one of the treatments exhibited alterations in radicular growth and germination rate of butter bean seeds. The in vitro anticholinesterase assay revealed an inhibitory concentration (IC50) of 72 µg/mL. These findings were corroborated by the in silico anticholinesterase assay, highlighting the potential of β-citronelene, limonene, β-acoradiene, and α-humulene to inhibit acetylcholinesterase. The in silico assay yielded binding energy values between -6.2 and -9.6 kcal/mol, closely resembling those of the galantamine inhibitor (-9.8 kcal/mol, RMSD 0.3678 Å). This study underscores the significant inhibitory activity of CsPO against AChE, suggesting its potential use in treating conditions like Alzheimer’s disease and other relevant ailments. Furthermore, this study aims to enhance the scientific understanding of this essential oil, thus contributing to its potential applications in agriculture and medicine.
Gender Marginalization and Entrepreneurial Motivation in the Global South
Authors: Onoshakpor Chioma , James Imaobong , Ibukun Tolulope , Irene Bridget
Published: September 2023

Purpose
This article sets out to the issues of gender marginalisation and entrepreneurial motivation are increasingly gaining interest in management, mainly to address social and gender exclusion. This paper explores the perceived differences in the motivating factors for women and men in choosing entrepreneurship as a career in a global south economy (Nigeria). This paper explores the perceived differences in the motivating factors for women and men in choosing entrepreneurship as a career in a global south economy (Nigeria). The study examines the role of patriarchy as it is perceived in Nigerian society, and how this might impact on the role of choosing entrepreneurship. These driving forces for entrepreneurship are typically divided into push and pull aspects. The push/pull theory is used to explore gender marginalisation, experienced by women in Nigeria.
Design/methodology/approach
The primary data were collected from semi-structured interviews with 14 males and 16 female entrepreneurs in hospitality and real estate sector in Nigeria. This data was analysed inductively and intuitively using an adapted form of grounded theory analysis. We used this data to develop a robust understanding of different factors that motivate men and women to choose entrepreneurship within Nigerian society.
Findings
Findings demonstrate that while supportive macro environment may be apparent, the entrepreneurial process is characterised, by deep set gendered constructions which policy alone may struggle to change. This is even more apparent due to the various levels of intersecting factors, in this case gender, class and religion.
Originality
This work is set in the sub-Saharan context of Nigeria, the findings illuminate a complex web of forces and how they contribute to a multi-faceted motivation for entrepreneurship.
A Comprehensive Review of Surgical Interventions for Advanced Lymphatic Filariasis: Current Approaches and Outcomes
Authors: Ali Anam Sayed Mushir , Kapil Challa Venkata Sai , Quadri Ahmed Alam , Chowdary Kalyani , Navya A. , Menezes Thanusha , Kathal Ritik , Siddiqua Ayesha
Published: September 2023

Lymphatic Filariasis (LF) is a debilitating disease especially in the advanced stages when the quality of life of the patient is grossly affected due to the associated deformities in the limbs and the urogenital system. In these advanced stages, medical management is seldom effective in improving the deformity and hence surgical management comes into play. Various surgical and micro-surgical techniques are brought into play with varying degrees of success. These range from excisional procedures and lymphatic shunts and anastomosis to hydrocelectomy for bancroftian filariasis. However, definitive studies are lacking on the subject. Therefore, we have investigated all these various techniques across the existing literature on the topic and presented our findings. It was concluded that surgical techniques when applied to advanced grades of lymphatic filariasis, leads to improvement in disfigurement and improved quality of life in the patients. There is a need to develop surgical procedures and medical advancement for optimal outcome of this disease therapeutics until then shunt followed by reduction surgery with skin graft is the most reliable option.
Rwanda’s pathway to net zero empowering smallholder farmers and forest restoration
Authors: Mugabowindekwe Maurice , Brandt Martin , Mukuralinda Athanase , Ciais Philippe , Reiner Florian , Kariryaa Ankit , Igel Christian , Chave Jerome , Mertz Ole , Hiernaux Pierre , Tong Xiaoye , Rwanyiziri Gaspard , Gominski Dimitri , Li Sizhuo , Liu Siyu , Gasangwa Ivan , Hategekimana Yves , Ndoli Alain , Nduwamungu Jean , Saatchi Sassan , Fensholt Rasmus
Published: September 2023

Landscape restoration initiatives are mainly focusing on forest regeneration and agroforestry especially in the Global South. However, due to a lack of monitoring tools, the carbon balance of restoration efforts remains poorly quantified. Here, we use satellite images from 2008 and 2019 to calculate carbon stocks for individual trees in Rwanda, a country which has been actively engaged in restoration activities over the past decade. We show that small-holder farmers on average planted about 3 trees per farm during 2008–2019, contributing about 50.4 million new trees at the national scale. The overall C sink of the new farmland trees was 0.13 Mg C ha− 1 yr− 1, which is 6 times lower than gains observed from restoration of degraded forests (0.76 Mg C ha− 1 yr− 1). If national greenhouse gas emissions remain at the level of 2019, agroforestry (~ 61% of national area coverage) and continued restoration of degraded natural forests (~ 0.5% of national area coverage) have the potential to offset about 80% of the national emissions before 2050. Our work monitors and quantifies progress and impact of landscape restoration projects and outlines a pathway to engage smallholder farmers with a limited number of on-farm trees into the expanding carbon market.
Assessment of blood microRNA expression patterns by predictive classification algorithms can diagnose myxomatous mitral valve disease in dogs
Authors: Palarea-Albaladejo Javier , Bode Elizabeth. F. , Partington Catheryn , Basili Mattia , Mederska Elzbieta , Hodgkiss-Geere Hannah , Capewell Paul , Chauché Caroline , Coultous Robert M , Hanks Eve , Dukes-McEwan Joanna
Published: September 2023

Background: Myxomatous Mitral Valve Disease (MMVD) is a commonly presenting and progressive cardiac pathology in dogs, and early medical intervention can delay progression. Current cardiac biomarkers can be useful in advanced clinical MMVD cases, but are unreliable in pre-clinical disease.Objectives:Assessment of canine serum and plasma expression profiles of 15 miRNA markers as a method to accurately discriminate MMVD patients from healthy controls. Additionally, an assessment of the same method to discriminate pre-clinical (stage B1/B2) from clinical (stage C/D) MMVD patients.Animals:Client-owned dogs (n = 123) were recruited. Following sample exclusions (n=26), healthy controls (n=50) and MMVD cases (n=47) were analyzedMethods:Multicenter, cross-sectional, retrospective investigation. MicroRNA expression profiles were compared between dogs, and the performance of predictive modelling to distinguish healthy controls from MMVD patients, and pre-clinical from clinical MMVD patients was evaluated.Results:Analysis of miRNA expression patterns by predictive classification algorithms could differentiate healthy controls from dogs with MMVD (sensitivity 0.85; specificity 0.82; accuracy; 0.83). Discrimination of pre-clinical (n=29) from clinical (n=18) MMVD cases resulted in promising results (sensitivity 0.61; specificity 0.79; accuracy 0.73). The method also compared advantageously to current biomarkers in a limited population.Conclusions and clinical importance:The analysis of miRNA expression profiles by probabilistic predictive classification algorithms provides a useful diagnostic tool to distinguish healthy controls from MMVD cases (stage B1 to D). Discrimination between pre-clinical and clinical MMVD cases by the same method yielded promising results, which could be further enhanced with an increased study population.
Role of Levatorplasty in Management of Rectal Prolapse in Patients with Wide Pelvic Hiatus
Authors: Shafik Ali Ahmed , El-barmelgi Mohamed Yehia , Mohamed Osama Refaei , Mohamed Mohamed Tamer , Badie Shady Fathy , Shafik Ali Ismail Ahmed
Published: September 2023

Purpose
Rectal prolapse (RP) is a debilitating condition associated with symptoms such as fecal incontinence, obstructed defecation, incomplete rectal evacuation, and significant discomfort. Recent evidence highlights the strong correlation between prolapse development and the size of the pelvic hiatus (GH). Surgical studies have suggested a potential link between an enlarged pelvic hiatus and prolapse recurrence. This study aims to evaluate recurrence rates in patients with rectal prolapse characterized by a wide pelvic hiatus who underwent surgical management.
Methods
In this prospective cohort study, 60 patients with rectal prolapse and a wide pelvic hiatus were divided into two groups, each comprising 30 patients. One group underwent rectal prolapse repair, while the other group underwent rectal prolapse repair with levatorplasty.
Results
The levatorplasty group exhibited notable improvements in Wexner scores and lower recurrence rates compared to the other group. Both groups demonstrated similar outcomes in terms of postoperative pain and dyspareunia.
Conclusion
Rectal prolapse repair combined with levatorplasty represents an effective approach for patients presenting with rectal prolapse and a wide pelvic hiatus. This combination results in improved Wexner scores and reduced recurrence rates, providing valuable insights into the management of this challenging condition.
Enhanced Omicron subvariant cross-neutralization efficacy of a SARS-CoV-2 BA.4/5 mRNA vaccine encoding a noncleaved, nonfusogenic spike antigen
Authors: Oh Jong-Won , Seo Han Young , Jung Haewon , Woo Hawon , Jung Hae-Gwang , Cho Hee , Bak Yeonju , Lee Se-Young , Son Yu-Min , Yoon Gone , Hwang Seo-Yeon , Park Inho , Shin Jeon-Soo
Published: September 2023

The rapid emergence of diverse SARS-CoV-2 variants, notably the Omicron variant, poses challenges to vaccine development. Here, we present a noncleaved, nonfusogenic spike (S) protein eliciting robust B- and T-cell immune responses against Omicron BA.5. The antigen incorporates the R685S and R815A mutations, effectively preventing the shedding of the S1 subunit and eliminating fusogenic activity of the resulting S antigen, termed S(SA). Through reverse genetic analysis, we found that the noncleaved form S protein with the R685S mutation enhances ACE2-dependent viral entry in vitro compared to the wild-type S protein, without increasing the virulence of the mutant virus in mice. The mRNA vaccine encoding the Omicron BA.4/5 S(SA) antigen conferred protective immunity in mice following two doses of 1 mg Ψ-UTP- or UTP-incorporated mRNA vaccines. Despite a roughly 6-fold reduction in neutralizing potency, both mRNA vaccines exhibited broad neutralizing efficacy against Omicron subvariants, including the XBB lineage variants XBB.1.5 and XBB.1.16.
Dinamika Feminisme Islam dalam Mendefinisikan Perempuan
Authors: Imamah Fardan Mahmudatul
Published: September 2023

Perempuan Muslim belum bersepakat tentang bagaimana hubungan antara feminisme dan Islam. Sebagian menerimanya sebagai bentuk upaya cendikiawan Muslim untuk menginterpretasikan kembali teks-teks keagamaan yang memiliki semangat kesetaraan. Di sisi lain, kritik terhadap feminisme yang dinilai membawa nilai-nilai Barat, nilai-nilai kolonial, dan definisi tunggal atas persoalan perempuan menyebabkan keraguan untuk menyebut upaya kesetaraan dalam Islam sebagai feminisme Islam. Artikel ilmiah ini mencoba untuk meninjau hubungan feminisme dan Islam dari sudut pandang filosofis dalam mendefinisikan perempuan, melalui studi tentang the self, the subject dan makna kesetaraan.  Apakah terdapat persamaan dan perbedaan antara feminisme dan Islam dalam mendefinisikan ketiga konsep tersebut. Kajian ini dimulai dari filsafat feminisme melalui teori eksistensialisme Simone De Beauvoir, lahirnya Feminisme Islam, reinterpretasi teks keagamaan, dan dinamika subjektivitas dalam mendefinisikan kebebasan. Hasilnya, perspektif Feminisme dan Islam tidak tunggal. Baik Feminisme dan Islam sepakat atas perempuan sebagai diri dan subjek yang setara antara laki-laki dan perempuan. Namun, terjadi perbedaan tentang bagaimana kesetaraan tersebut didefinisikan khususnya hak-hak dan kewajiban.
Fenomena Kidfluencer dalam Beretika Media Sosial
Authors: Astuti Irawati Diah
Published: September 2023

Media sosial saat ini menjadi bagian kehidupan yang sulit dipisahkan dari masyarakat. Bahkan, media sosial juga menjadi lahan bagi sebagian orang untuk mengais rupiah yang dipergunakan untuk berbagai kebutuhan hidup. Tak hanya orang dewasa, anak-anak juga turut hadir di media sosial sebagai objek untuk menghasilkan uang. Padahal, penggunaan media sosial dibatasi oleh aturan usia untuk menghindari berbagai hal yang bisa membahayakan anak di masa depan. Namun, orang-orang dewasa, yang umumnya merupakan orang tua si anak itu sendiri, melegitimasi terjunnya anak-anak ke media sosial demi berbagai alasan, salah satunya adalah popularitas dan keuntungan  finansial. Penelitian ini menggunakan paradigma konstruktivis dengan pendekatan kualitatif. Strategi penelitian yang digunakan adalah studi pustaka dengan metode pengumpulan data berupa mencari literatur ilmiah yang sesuai dengan tema serta mengobservasi media sosial milik beberapa kidfluencer. Dalam artikel ini, penulis membahas fenomena kidfluencer di media sosial dari perspektif etika. Apakah kehadiran anak-anak sebagai selebriti media sosial sesuai dengan etika? Bagaimana seharusnya peran dan tanggung jawab orang tua dilihat dari perspektif etika? Hasilnya menunjukkan bahwa tindakan orang tua yang membagikan informasi tentang anaknya di media sosial bertentangan dengan etika. Sebab, membagikan konten anak di media sosial akan melucuti sisi humanitas orang tua terutama dari sisi etika.
Relating non-Hermitian and Hermitian quantum systems at criticality
Authors: Hsieh Chang-Tse , Chang Po-Yao
Published: September 2023

We demonstrate three types of transformations that establish connections between Hermitian and non-Hermitian quantum systems at criticality, which can be described by conformal field theories (CFTs). For the transformation preserving both the energy and the entanglement spectra, the corresponding central charges obtained from the logarithmic scaling of the entanglement entropy are identical for both Hermitian and non-Hermitian systems. The second transformation, while preserving the energy spectrum, does not perserve the entanglement spectrum. This leads to different entanglement entropy scalings and results in different central charges for the two types of systems. We demonstrate this transformation using the dilation method applied to the free fermion case. Through this method, we show that a non-Hermitian system with central charge c = -4c=−4 can be mapped to a Hermitian system with central charge c = 2c=2. Lastly, we investigate the Galois conjugation in the Fibonacci model with the parameter \phi \to - 1/\phiϕ→−1/ϕ, in which the transformation does not preserve both energy and entanglement spectra. We demonstrate the Fibonacci model and its Galois conjugation relate the tricritical Ising model/3-state Potts model and the Lee-Yang model with negative central charges from the scaling property of the entanglement entropy.
ADAPTIVE FUZZY STATE OBSERVER BASED ROBUST CONTROLLER FOR A ROBOTIC SYSTEM
Authors:   Department of Electrical Engineering/ Engineering College/ Shaqra University, Shaqra 11961, Saudi Arabia., Nufaie L. Al
Published: September 2023

In this paper we propose to develop an adaptive type-2 fuzzy robust controller with a stat observer to control a robotic system. For this, we the approximate the system with two type-2 fuzzy systems. To overcome the problem of the state measures, we propose a state observer allowing to converge quickly to the real values and hence guarantees the stability of the closed loop system. The robustness of the closed loop system is ensured by using a modified sliding mode control, where the chattering phenomenon are removed. Simulation results are given to show the efficiency of the proposed approach.
CHARACTERIZATION OF WASTEWATER FROM HEALTH FACILITIES: CASE OF THE HOSPITAL OF TREICHVILLE IN ABIDJAN, COTE DIVOIRE
Authors:   Laboratoire des Sciences de lEnvironnement, UFR des Sciences et Gestion de lEnvironnement, Universite NANGUI ABROGOUA, 02 BP 801 Abidjan 02, Cote dIvoire., Kossonou Roland NGUETTIA , Donafologo Baba SORO ,   Laboratoire des Sciences de lEnvironnement, UFR des Sciences et Gestion de lEnvironnement, Universite NANGUI ABROGOUA, 02 BP 801 Abidjan 02, Cote dIvoire., Moussa DIARRA ,   Laboratoire des Sciences et Technologies de lEnvironnement (LSTE), Universite Jean Lorougnon GUEDE, BP 150 Daloa, Cote dIvoire. Universite Jean Lorougnon GUEDE, BP 150 Daloa, Cote dIvoire., Dembele ARDJOUMA ,   Laboratoire dEcologie et de Developpement Durable, UFR des Sciences de la Nature, Universite NANGUI ABROGOUA, Abidjan, Cote dIvoire., Karim Sory TRAORE ,   Laboratoire des Sciences de lEnvironnement, UFR des Sciences et Gestion de lEnvironnement, Universite NANGUI ABROGOUA, 02 BP 801 Abidjan 02, Cote dIvoire.
Published: September 2023

The aim of this study was to identify pollutants and contaminants in the wastewater generated by the Treichville Hospital, to assess their potential impact on the environment and public health, and to propose appropriate treatment and management methods to reduce this impact. The methodology used for this study included the selection of four sampling points in the hospitals wastewater system. Samples were collected and analyzed for different parameters, including overall pollution parameters (pH, temperature, dissolved oxygen, etc.) and drug residues (anticancer drugs and antibiotics). The results showed that the wastewater generated by the Hospital of Treichville is highly contaminated with organic matter. Ammonium levels in the wastewater discharges from Treichville Hospital were high. All targeted anticancer and antibiotic molecules were detected in the wastewater of the hospital. Concentrations of 5-fluorouracil were above the PNEC (predicted no effect concentration), while concentrations of cyclophosphamide and ifosfamide were below the PNEC. These results indicate that the presence of drug residues in the environment poses a potential risk to human and ecosystem health. In conclusion, measures must be taken to effectively treat these wastewaters to minimize their impact on the environment and public health.
SYNDROME DU TUNNEL CUBITAL DUE AU MUSCLE ANCONEUSEPITROCHLEARIS : A PROPOS DUN CAS
Authors:   Service Chirurgieorthopedique A, Hopital Ibn Tofail, CHU Mohamed VI, Marrakech., Achkoun Abdessalam , Chafiq Rachid ,   Service Chirurgieorthopedique A, Hopital Ibn Tofail, CHU Mohamed VI, Marrakech.
Published: September 2023

Ulnar tunnel syndrome in the elbow is a common ductal neuropathy of the upper limb. The discovery of the anconeusepitrochlearis muscle may be an etiology of this compressive neuropathy, whose management in the event of failure of medical treatment consists of resection of this muscle to relieve the ulnar nerve and avoid sometimes dramatic functional consequences.
GENESIS AND DEVELOPMENT OF THE BANGLADESH CIVIL SERVICE - A REFORM PERSPECTIVE
Authors: Mannan M.A.
Published: September 2023

This paper focuses on the historical context of Civil Service Reform (CSR) in Bangladesh. Specifically, it explores the genesis and development of the Bangladesh Civil Service (BCS) Administration cadre, with reference to different reform programs that have been undertaken since independence. This paper will place an emphasison civil service reform in contextual perspective. In Bangladesh it has been a practice for every new political regime to initiate reform planning through commissions and committees. Nevertheless, most of their recommendations have remained unimplemented for several reasons. As many as 20 committees and commissions on public administration (PA) reform were formed since 1971. International donor agencies have also conducted several inquiries and studies. Both government and donor agency recommendations have called for reforming public sector management, in general, and for reforming different CSR issues, in particularâ€” such as recruitment, training, career management, performance management and retirement. These are the main focal areas in the BCS HRM structure that are within the scope of this paper.
EFFECT OF ACADEMIC STRESS, LONELINESS AND LIFE SATISFACTION ON AGGRESSION LEVELS OF STUDENTS: A COVID-19 CONTEXT
Authors:   Undergraduate Student, Dept. of Psychology, Adamas University., Sengupta Roshni
Published: September 2023

The Covid-19 pandemic has forced students to stay in prolonged social isolation and attend online classes, giving rise to newer academic challenges, enhanced feelings of loneliness, and hence, decreased life-satisfaction. These can further heighten aggression in students. Empirical evidence suggests that academic stress has a positively-significant correlation with aggression although, studies inspecting the correlation of these factors with loneliness and life-satisfaction, in light of the Covid-19 pandemic are scarce. Present study therefore aims to investigate the effect of Academic Stress, Loneliness and Life-Satisfaction on Aggression Levels of Students, from a Covid-19 context. Data were collected in the year 2021, from 215 students (Mean age=20.69, SD=3.60 59.5% females), attending both online and offline classes by administering (a) Aggression Questionnaire by Bus and Perry (1992), (b) Educational Stress Scale by Sun et al. (2011), (c) UCLA Loneliness Scale by Russell et al. (1978), and (d) Satisfaction with Life Scale by Diener et al. (1985). Data were collected using Google Forms after obtaining consent from participants. Statistical Analysis included Descriptive Statistics, Correlation Analysis, Regression Analysis, and One-Way ANOVA. Findings indicate that aggressionof the students is positively associated with educational stress, and loneliness and negatively associated with life satisfaction level. Educational stress and loneliness significantly predict aggression in students, but life satisfaction does not predict aggression. Present findings provide empirical evidence of the contribution of educational stress and loneliness in enhancing aggression in students. Findings have implications in developing intervention modulesfor behavioural problems among students attending online classes.
INTEGRITY FORMATION COMPONENTS IN SOCIAL INSTITUTIONS ACCORDING TO THE PERSPECTIVE OF THE QURAN
Authors:   Senior Lecturer, Academy of Contemporary Islamic Studies (ACIS) UniversitiTeknologi MARA (UiTM), Shah Alam., Sarah Binti Izham Siti , Aznaim Abd Latib Noor ,   Senior Lecturer, Academy of Contemporary Islamic Studies (ACIS) UniversitiTeknologi MARA (UiTM), Shah Alam., Ahmadun Musaiyadah ,   Senior Lecturer, Academy of Contemporary Islamic Studies (ACIS) UniversitiTeknologi MARA (UiTM), Shah Alam., Khairul Izwan Rifin Mohamad ,   Senior Lecturer, Academy of Contemporary Islamic Studies (ACIS) UniversitiTeknologi MARA (UiTM), Shah Alam.
Published: September 2023

Social institutions have a great role and influence on society in shaping the integrity of an individuals identity. The level of understanding and implementation of this integrity is very important in the progress of the country. This means that integrity is the main key to the development of a country. Therefore, the main objective of this study is to produce integrity-building components that are analyzed according to the guidance of the Quran. This study is qualitative and uses data collection methods from library research. Meanwhile, the main data analysis method used is to analyze the content found in books of interpretation in addition to documents from journal articles and academic books. The results of the study found that there are four main components of the formation of integrity in social institutions. First, piety. Second, trust. Third, qanaah. And fourth, tabligh (conveying). These four components of integrity that are sourced from the Quran are very important to be understood, nurtured and educated to the community in social institutions so that the result produces a society with integrity and brings prosperity and harmony to the country.
A CASE REPORT ON THE BILATERAL PSOAS MINOR MUSCLES WITH CLINICAL SIGNIFICANCE
Authors: Raj Sharma Amit , Chawla Kunal
Published: September 2023

The Psoas Minor is a thin paired muscle of the posterior abdominopelvic region, placed in front of the Psoas major.The psoas minor muscle is considered inconstant and is often absent, only being present in about 40% of human specimens studied.The psoas minor muscle originates from the vertical fascicles inserted on the last thoracic and first lumbar vertebrae. From there, it passes down onto the medial border of the psoas major and is inserted to the innominate line and the iliopectineal eminence. Additionally, it attaches to and stretches the deep surface of the iliac fascia and occasionally its lowermost fibers reach the inguinal ligament.
MASSAGE THERAPY- MASSAGE AND HEALTH
Authors:   Associate Professor, Department of Kulliyate Tib, Govt. Tibbi College & Hospital Patna., Akhtar Jamal , Tanwir Alam Md. ,   Assistant Professor, Department of Kulliyate Tib, Govt. Tibbi College & Hospital Patna., Fahad Md. ,   PG Scholar, Department of Kulliyate Tib, Govt. Tibbi College & Hospital Patna., Tauhid Alam Md. ,   PG Scholar, Department of Kulliyate Tib, Govt. Tibbi College & Hospital Patna.
Published: September 2023

Ilaj bit tadbeer is one of the effective modes of treatment that has been described in Unani system of medicine, in classical text about sixty four different types of regimens like Hammam, Dalk, Riyazat, Fasd, etc. are described. Among them, massage is one of the famous regimens practiced all over the world since antiquity. Massage therapy is increasingly becoming an integral part of a growing number of peoples holistic health regimens. More and more medical doctors are prescribing massage therapy to treat a broad range of medical conditions. Unani scholars have provided a detailed description of the massage under the category of Dalk. It has an effect on both body and mind and is a system of stroking. A manual literature survey obtained from classical Unani texts such as Kulliyat Nafisi, Kulliyat-e-Qanun, Kitabul-Kulliyat, Al Qanoon-Fit-tib, Kamilus Sana, Canon of Medicine and online databases including PubMed, Google Scholar, and Web of Science etc. The current review designed to give an overview on massage therapy that can provide several benefits to the body like improved blood flow, reduced muscle pressure, neurological excitability, and increased sense of well-being. Although scientific studies have successfully found many benefits of massage therapy, in recent years massage has gain international attention due to its wide range of effectiveness in management of different types of diseases.
VIRAL HEPATITIS-PROGRESS TOWARDS ELIMINATION
Authors:   Department of Medical Surgical Nursing, PG Nursing Tutor, Ras Bihari Bose Subharti University, Uttarakhand, India., Kukreti Aradhana
Published: September 2023

Viral hepatitis affects millions of people worldwide1. WHO aims to eliminate viral hepatitis by 2030 by reducing deaths and new infections from hepatitis B, hepatitis C and HBsAg to <0.1% in children under 5 years of age. Viral hepatitis is an infection of the liver that causes inflammation and liver damage 2 There are several types of viruses that cause hepatitis, including hepatitis A, B, C, D, and E 3. The purpose of this article is to review epidemiology, review articles from PubMed, NCBI, WHO, CDCs strategic framework for global immunization, and hepatitis elimination, prevention, and treatment to introduce viral hepatitis, vaccination against hepatitis, and observed global hepatitisefforts to end it.
TOURISTS SATISFACTION LEVEL ANALYSIS OF BASIC TOURISM FACILITIES: A STUDY IN HILL REGION OF HIMACHAL PRADESH
Authors:   Assistant Professor GDC Nirmand/Ph.D. Research Scholar, Department of Humanities & Social Sciences, IEC University Baddi (HP) India-173205., Kumar Thakur Sandeep , Kumar Chaturvedi Ajay ,   Dean & Professor/Supervisor Department of Humanities & Social Sciences, IEC University Baddi (HP) India-173205.
Published: September 2023

In Himachal Pradesh, the tourism industry is booming and supports both domestic and international travel in order to improve peoples quality of life and satiate their need for knowledge. Although the public sector has been essential in providing infrastructure, either directly or through Public Private Partnership (PPP) form, the travel and tourism sector is mostly one of private sector service providers. It is a multi-sectoral company that stands out for the variety of services the vendors provide. In the manufacturing industry, where both the supply chain and the finished product are equally important, it is quite analogous. Only a few examples include airlines, ground transportation, hotels, essential infrastructure, and other related sectors. Therefore, it is impossible to achieve the expansion of tourism until all the issues pertaining to the pertinent sectors are simultaneously addressed. The State has a wealth of scenic, natural, and cultural features to offer travellers. Himachal is enticing because of its snow-capped mountains, sparkling rivers, serene surroundings, great climate, and peaceful way of life. The state is rich in tribal culture, dialects, folklore, attire, and cuisine, particularly Himachal cuisine, in addition to its abundance of natural beauty. The State is equipped to draw visitors from a variety of demographics. However, improving accessibility and focusing on the right potential markets require infrastructure.
Developing and tailoring business process management methods using the situational method engineering approach
Authors: Lahajnar Sebastian , Rožanec Alenka
Published: September 2023

Effective business process management is one of the key tasks of every organization if it wants to compete successfully on the market and satisfy the needs of its customers. Although there are many established best practices, techniques, and more or less complex methods in business process management, no approach can fulfill a typical organization’s needs and wants. The key to success lies in developing new or adapting existing approaches for business process management to suit the unique characteristics of individual organizations and projects. This demands a solid methodological framework and a clearly defined work process. The aim of the paper is to apply situational method engineering concepts within the realm of business process management, thereby tackling the challenge mentioned above. As a result, a situational method engineering framework is defined to construct and customize business process management methods. The study proposes the conceptual foundations of the framework and a set of processes for constructing holistic and tailored methods that cover various aspects of business process management (analysis, modeling, management, etc.). The basis of the framework is represented by general method components at a higher level of abstraction, which are assembled into holistic methods via interfaces and are transformed into versions adapted to specific situations using tailoring rules. The practical applicability of the proposed framework is validated through its implementation in a project at a large manufacturing company, where it is used to develop both a general and customized business process management method.
A School Life from Learning Disability to Giftedness
Authors: BİLDİREN Ahmet , FIRAT Tahsin , KAVRUK Sevinç Zeynep
Published: September 2023

Introduction: Can a student with learning disability pass the university exam and get into the faculty of medicine? Number of studies on gifted students with learning disabilities, also known as different students, has increased recently. The aim of the present study was to examine the strengths and weaknesses of Fatih who succeeded in getting into the faculty of medicine despite academic failure and to determine strategies he used against problems.
Method: Case study among qualitative research methods was used as the study model. Through family interviews, interviews with Fatih, the drawings of Fatih and result of intelligence test, areas he had difficulties as well as those he was gifted were analyzed.
Findings: Results of the study revealed that Fatih has been suffering from learning disability since primary school, he has struggled especially in the Turkish lesson and he has been experiencing academic failure. Despite his academic failure, he performed well in the field of mathematics. In addition, he was gifted in general mental ability and that he is extraordinarily skilled at painting.
Discussion: When the strengths and weaknesses of Fatih are taken into consideration, it can be asserted that he is a gifted student with learning disability. The results were discussed within the context of identifying gifted individuals with learning disability.
Pengembangan Sistem Layanan Administrasi Kependudukan Desa Papasan dengan QR Code sebagai Validasi Dokumen
Authors: Wibowo Nur Cahyo Hendro , Khaq Albadru Muh Izul , Nur'aini Siti
Published: September 2023

Papasan Village is located in the Bangsri sub-district, Jepara district. The process of managing mail services in a day serves 20 submissions of letters. This mail service process is still done manually so it takes a relatively long time. Another problem is the potential for document falsification because administrative data reports are not recorded properly, so in this study a population administration service system was developed that utilizes the Quick Response Code (QR Code). System development is carried out using the waterfall method. The system design stage is carried out using Data Flow Diagrams, while the database design is carried out by compiling a Physical Data Model. The QR Code on the letter is scanned through the system to determine the authenticity of the letter. System testing involved 30 respondents consisting of village heads and village residents. The first test using a black box results that the system can run if the data entered is appropriate and the data is not empty. The second test uses the User Acceptance Test (UAT), the total percentage results are 88% or the system is in the very good category. Desa Papasan terletak di kecamatan Bangsri, kabupaten Jepara. Proses pelayanan pengurusan surat dalam sehari melayani 20 pengajuan surat. Proses pelayanan surat ini masih dilakukan secara manual sehingga membutuhkan waktu yang relatif lama. Permasalahan lainnya adalah adanya potensi pemalsuan dokumen karena laporan data administrasi tidak tercatat dengan baik, maka dalam penelitian ini dikembangkan sistem pelayanan administrasi kependudukan yang memanfaatkan Quick Response Code (QR Code). Pengembangan sistem dilakukan dengan menggunakan metode waterfall. Tahap perancangan sistem dilakukan dengan menggunakan Data Flow Diagram, sedangkan perancangan basis data dilakukan dengan menyusun Model Data Fisik. QR Code pada surat dipindai melalui sistem untuk mengetahui keaslian surat. Pengujian sistem melibatkan 30 responden terdiri dari kepala desa dan warga desa. Pengujian pertama menggunakan black box hasilnya sistem dapat berjalan jika data yang dimasukkan sesuai dan data tidak kosong.