bluuebunny/crossref_metadata_2025 huggingface dataset:
Celiac disease - a comprehensive review
Authors: Radlovic Nedeljko , Lekovic Zoran , Mladenovic Marija , Vuletic Biljana , Radlovic Jelena , Ducic Sinisa , Nikolic Dejan
Published: November 2023

Celiac disease is a multisystemic autoimmune disease induced by gluten in wheat, rye, and barley. It is characterized by polygenic predisposition, prevailing prevalence in members of the white population (1%), especially in close relatives (5?15%), very heterogeneous expression and frequent association with other autoimmune diseases (3?10%), as well as selective deficiency of IgA and Down, Turner, and Williams syndromes. The basis of the disease and the key finding in its diagnostics is gluten-sensitive enteropathy, i.e., non-specific inflammation of the small intestinal mucosa which resolves by gluten-free diet. In addition to enteropathy, whether symptomatic or asymptomatic, the disease is also characterized by various extraintestinal manifestations, and even very serious complications. Therapy is based on a lifelong glutenfree diet, so that the disorder, if diagnosed in time and treated consistently, has an excellent prognosis.
Open retropubic radical prostatectomy versus external beam radiation therapy for localized prostate cancer - patient-reported outcomes
Authors: Basic Dragoslav , Skakic Aleksandar , Stevic Milos , Ignjatovic Aleksandra , Mirkovic Zarko , Ignjatovic Ivan , Janic Jovan , Veljkovic Andrej , Jankovic-Velickovic Ljubinka , Hadzi-Djokic Jovan
Published: November 2023

Introduction/Objective. Active treatment options for localized prostate cancer (LPCa) include surgery and radiotherapy with androgen deprivation therapy (ADT) in selected cases, but all options have side effects, mainly addressed to urinary, sexual, and bowel function. Our study aimed to assess and compare patient-reported outcome measures (PROMs) after open retropubic radical prostatectomy (ORRP) or external beam radiotherapy (EBRT). Methods. Between June 2019 and May 2021, a total of 120 patients, with LPCa had undergone active treatment, as follow: ORRP ? 60 patients and EBRT ? 60 patients. A validated questionnaire, the Expanded Prostate Cancer Index Composite Short Form (EPIC-26) instrument was used to assess PROM, through the following domains: urinary, sexual and bowel. Patients completed a questionnaire at baseline and six, 12, and 24 months after primary treatment. Results. All urinary scores had statistically significant interaction between time and group. After six, 12, and 24 months, all urinary scores were statistically significantly lower in the ORRP group. After 12 and 24 months, bowel score values were statistically significantly lower in patients in the ERBT group. Sexual scores change statistically significant during the follow-up period, without difference between the groups (p < 0.05). Conclusion. Both ORRP and EBRT are associated with decline of sexual scores. ORRP showed significant variations in all urinary scores, with more pronounced negative impact on urinary symptoms compared to EBRT during the entire follow-up period. Bowel scores are lower in EBRT.
Efficacy and Safety of Mazdutide in Chinese Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial
Authors: Zhang Bo , Cheng Zhifeng , Chen Ji , Zhang Xin , Liu Dexue , Jiang Hongwei , Ma Guoqing , Wang Xiaoyun , Gan Shenglian , Sun Juan , Jin Ping , Yi Jianjun , Shi Bimin , Ma Jianhua , Ye Shandong , Wang Guixia , Ji Linong , Gu Xuejiang , Yu Ting , An Pei , Deng Huan , Li Haoyu , Li Li , Ma Qingyang , Qian Lei , Yang Wenying
Published: November 2023

OBJECTIVE

We conducted a randomized, double-blind, placebo-controlled phase 2 trial to evaluate the efficacy and safety of mazdutide, a once-weekly glucagon-like peptide 1 and glucagon receptor dual agonist, in Chinese patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS

Adults with type 2 diabetes inadequately controlled with diet and exercise alone or with stable metformin (glycated hemoglobin A1c [HbA1c] 7.0–10.5% [53–91 mmol/mol]) were randomly assigned to receive 3 mg mazdutide (n = 51), 4.5 mg mazdutide (n = 49), 6 mg mazdutide (n = 49), 1.5 mg open-label dulaglutide (n = 50), or placebo (n = 51) subcutaneously for 20 weeks. The primary outcome was change in HbA1c from baseline to week 20.

RESULTS

Mean changes in HbA1c from baseline to week 20 ranged from −1.41% to −1.67% with mazdutide (−1.35% with dulaglutide and 0.03% with placebo; all P < 0.0001 vs. placebo). Mean percent changes in body weight from baseline to week 20 were dose dependent and up to −7.1% with mazdutide (−2.7% with dulaglutide and −1.4% with placebo). At week 20, participants receiving mazdutide were more likely to achieve HbA1c targets of <7.0% (53 mmol/mol) and ≤6.5% (48 mmol/mol) and body weight loss from baseline of ≥5% and ≥10% compared with placebo-treated participants. The most common adverse events with mazdutide included diarrhea (36%), decreased appetite (29%), nausea (23%), vomiting (14%), and hypoglycemia (10% [8% with placebo]).

CONCLUSIONS

In Chinese patients with type 2 diabetes, mazdutide dosed up to 6 mg was generally safe and demonstrated clinically meaningful HbA1c and body weight reductions.
Mekanokimyasal Yöntemle FeB ve Fe2B Bileşiklerinin Üretimi ve Karakterizasyonu
Authors: Çelik Ülkü Aslı , Sunar Talha , Özyürek Dursun , Gürü Metin
Published: November 2023

Bu çalışmada, demir ve bor tozları, farklı oranlarda (molar ağırlıklarına göre) spex tipi öğütme cihazında mekanokimyasal işlemle (katı faz reaksiyonu) FeB ve Fe2B bileşikleri elde edilmiştir. Farklı mol oranlarında karıştırılan demir ve borun muhafazası ve hassas ölçümleri Glove-Box ile argon atmosferinde gerçekleştirilmiştir. Alaşımların sinterleme sıcaklığının tespiti için Termogravimetrik ve Diferansiyel Termal Analiz; faz bileşimlerini ve mikroyapılarını incelemek amacıyla da X-ışını kırınım analizi (XRD) ve Taramalı Elektron Mikroskobu (SEM) analizleri yapılmıştır. Yapılan çalışmalar sonucunda, yüksek oranda amorf yapıda ve ağırlıklı olarak hedeflenen Fe2B ve FeB bileşikleri üretilmiştir. Stokiyometrik katsayılardan kaynaklı olarak FeB bileşimine ait piklerin daha belirgin olduğu görülmüştür. EDS analizinden numunelerin yüzeyinde bulunan demir ve bor elementlerinin yapıda homojen bir dağılım sergilediği anlaşılmıştır. Sertlik sonuçlarına göre, FeB olarak hedeflenen numunenin, Fe2B olarak hedeflenen numunelere göre daha sert olduğu anlaşılmaktadır. Bu çalışma farklı oranlardaki bileşimlerin sentezlenmesiyle bölgesel sertlik rejimlerine sahip ileri malzemelerin üretilebilmesine katkı sağlayacaktır.
Arbetsintegrerat lärande genom lärandesamtal med föräldrar: En grund för pedagogers utveckling i arbete
Authors: Seitl Camilla , Eriksson Lisbeth
Published: November 2023

I följande studie undersöks hur pedagoger beskriver sitt eget lärande och sin identitetsutveckling i ljuset av införandet av en ny typ av föräldrasamtal. Föräldrasamtalen som genomförts har skett på gruppnivå med föräldragrupper istället för de traditionella utvecklingssamtalen. I samtalen riktar pedagogerna in sig på interaktion och kollektivt lärande hos barn och vårt material för den här studien utgörs av texter som pedagogerna har skrivit för att reflektera över den nya samtalsmodellen. Syftet med studien är att förstå samtalen som en aktivitet genom vilken pedagogers lärande och identitet i arbete kan utvecklas. Texterna har analyserats genom innehållsanalys. Genom studien belystes hur förskolepedagogerna utmanas kunskapsmässigt i sammanhang med föräldrar och kollegor, varför det blir viktigt för pedagogerna att reflektera över arbetet och den egna utvecklingen. Resultatet visar hur dessa gruppsamtal bidrar till pedagogernas yrkesidentitet och lärande i arbete. 
ENGLISH ABSRACT
Work integrated learning through learning conversations with Parents: A Platform for developing Preschool Teachers’ Learning at Work
The following study examines how preschool teachers describe their own learning and their own identity development concerning the introduction of a new type of parent-teacher conference. The conversation that has been conducted has taken place with groups of parents instead of the traditional individual conversations between parents and preschool teachers. In the conversations, the preschool teachers focus on interaction and collective learning among children, and our material for this study consists of texts that the preschool teachers have written to stimulate reflection concerning the new conversation model. The purpose of the study is to understand the conversations as an activity through which a preschool teacher’s learning and identity at work can be developed. Using content analysis, the study highlights how preschool teachers are challenged in terms of knowledge in the context of parents and colleagues, which is why it becomes important for preschool teachers to reflect upon their work and their own development. In addition, the results show how these group conversations contribute to the preschool teacher’s professional identity and learning at work.
Planverkets blindsone? En analyse av profesjonsfaglig digital kompetanse i emneplanbeskrivelser for barnehagelærerutdanning
Authors: Madsen Siri Sollied , Unstad Torstein , Tveiterås Nils Christian , Dardanou Maria , Habbestad Helge , Kosner Lukas
Published: November 2023

Denne studien er en systematisk undersøkelse av hvordan profesjonsfaglig digital kompetanse fremgår av læringsutbyttebeskrivelser i obligatoriske emner på barnehagelærerutdanningene i Norge. Vi har gjennomført en innholdsanalyse av emneplaner til 15 forskjellige studieprogrammer for barnehagelærerutdanning, noe som har resultert i analyse av 100 forskjellige emneplanbeskrivelser. Til tross for at nasjonale retningslinjer slår fast at profesjonsfaglig digital kompetanse skal vektlegges i barnehagelærerutdanninger, behandles dette området først og fremst som et ferdighets- og kunnskapsområde i læringsutbyttebeskrivelsene. Kun to av 14 institusjoner har utarbeidet læringsutbyttebeskrivelser som er definert som generell kompetanse. Vi konkluderer i denne artikkelen med at det eksisterer et gap mellom nasjonale retningslinjer for norsk barnehagelærerutdanning og utarbeidelse av læringsutbyttebeskrivelser i lokale emneplaner.
ENGLISH ABSTRACT
A blind spot in curricula? An analysis of professional digital competence in subject curricula for early childhood teacher education
This study is a systematic investigation on how professional digital competence is implemented in descriptions of learning outcomes for mandatory subjects in early childhood teacher education in Norway. We describe a content analysis of subject curricula for 15 different study programs for early childhood teacher education, which has resulted in a total of 100 different subject curricula. Even though it is defined through national guidelines that professional digital competence is to be emphasized in the study program, this is mainly expressed through learning outcomes defined as knowledge and skills. Only two of 14 institutions have developed descriptions of learning outcomes defined as general competency. In this article we conclude that there is an existing gap between national guidelines for Norwegian early childhood teacher education and the developed learning outcomes in local subject curricula.
Å redde eller avskrekke? Synet på fattigdom ved etablering av institusjoner for ulike grupper fattige i Mandal og Halse rundt århundreskiftet 1900
Authors: Olsen Thomas
Published: November 2023

This chapter examines the attitudes of the local community towards various groups of impoverished people in two municipalities in Agder around the turn of the 20th century. The study is based on the debates that unfolded regarding the establishment of institutions such as poor farms, nursing homes for elderly people, and orphanages in the urban municipality of Mandal and the surrounding rural municipality of Halse. The prevalent belief was that poverty stemmed from individual and moral factors. However, the findings demonstrate that in the early 1900s, certain groups and communities began to critique the moralistic and individually focused explanations of poverty. They underscored that poverty was primarily a result of external factors such as illness, old age, and unemployment, and argued that the arrangements of the poverty relief system constituted demeaning and stigmatizing forms of assistance. There was a desire for a renewal of poverty relief, calling for various groups of the impoverished to be removed from the old, all-encompassing poverty relief system and be provided with more differentiated forms of assistance such as nursing homes and various types of social insurance.
Skeiv regionalhistorie – tre fortellinger fra Agder1
Authors: Hundstad Dag
Published: November 2023

The subject of this chapter is the queer history of the Agder region in the times before male homosexuality was decriminalised in 1972. The starting point is three biographical narratives from Agder: Karen Bleken, a school teacher, Benn Fuhr, the son of an industrialist, and Axel Krogh, an author. The three persons represent different phases of and perspectives on queer history. As a spinster, Karen Bleken represents a premodern discourse on queerness. Benn Fuhr was diagnosed as a homosexual in the interwar period, and specialists tried to cure him according to modern medical discourse. During the same period, Axel Krogh worked as an author. He wrote about and tried to live out a modern queer identity, despite experiencing social exclusion. At the end of the chapter, different research questions about the queer regional history of Agder is discussed. This is a field where knowledge is still scant. For instance, we do not know whether, and in what ways, attitudes towards queers were different in Agder compared to other Norwegian regions. Nor do we know whether the strong religious culture in this region was able to support queers with discrete safe spaces.
Mellom fordømmelse og fortielse: Dekningen av Folkebevegelsen mot innvandring i lokale aviser fra Aust-Agder
Authors: Vadum Kristoffer
Published: November 2023

This chapter examines how five newspapers in the eastern part of Agder covered the local impact of the anti-immigrant movement known as FMI in the period between 1987 and 1993. Although FMI was organized as a nationwide movement, it became inextricably connected to Agder, as FMI’s front figure was based in Arendal, and a number of spectacular controversies unfolded there. Regarding the latter, the newspapers stand out as important sources, as little documentary evidence of the movement can be found in local archives. Yet the coverage is marked by the common dilemma of the local press: familiarity provided access to sources, but also entailed concerns for the well-being of the local community. The newspapers examined in this study show much variation in the overall editorial attitude to FMI. Ranging between concealment and condemnation, only Agderposten maintained continuous coverage of the movement throughout the period. At the same time, Agderposten’s documentary value is limited in certain areas, in particular with regard to FMIs organizational appeal in the region and the issue of underlying racism in the community.
Accounting Conservatism: Gender Diversity Accounting Conservatism: Gender Diversity and Educational Background on the Board of and Educational Background on the Board of Directors and Commissioner
Authors: Witono Banu , Permatasari Widowati Dian , Puspawati Dewita
Published: November 2023

This research aimed to analyze the effect of the board director’s characteristics and the board of commissioners toward accounting conservatism. The characteristics analyzed in this research were size, gender, and educational background that affect their behavior in dealing with issues related to accounting principles. This research will be conducted by analyzing all companies listed on the Indonesia Stock Exchange in 2017-2019 using SPSS. Data was analyzed as 112 data using multiple regression analysis. The results show that both size of directors and commissioner’s and women of board director and commissioners affect the accounting conservatism. However, the educational background of board directors and commissioners does not affect accounting conservatism.
Features of (Benzo)Imidazo[2,1-b][1,3]thiazine Mezylates Reaction with Nucleophilic Reagents
Authors:   Department of Organic Chemistry and Pharmacy, Lesya Ukrainka Volyn National University, Volya Ave. 13, Lutsk 43025, Ukraine, Slyvka Nataliia , Saliyeva Lesya ,   Department of Organic Chemistry and Pharmacy, Lesya Ukrainka Volyn National University, Volya Ave. 13, Lutsk 43025, Ukraine, Litvinchuk Mariia ,   Department of Functional Heterocyclic Systems, Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Acad. Kuharya St. 5, Kyiv 02660, Ukraine, Shishkina Svitlana ,   Department of X-ray Diffraction Study and Quantum Chemistry, SSI “Institute for Single Crystals”, National Academy of Sciences of Ukraine, Nauka Ave. 60, Kharkiv 61000, Ukraine, Vovk Mykhailo ,   Department of Functional Heterocyclic Systems, Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Acad. Kuharya St. 5, Kyiv 02660, Ukraine
Published: November 2023

Peculiarities of the course of the methanesulfo-derivatives of (benzo)imidazo[2,1-b][1,3]thiazines reac-tions with a number of nucleophilic reagents were studied. It was determined that they react nonselectively with potassium thiocyanate to form a mixture of thio- and isothiocyanate derivatives. When interacting with sodium azide, nucleophilic substitution competes with an elimination reaction. The latter is dominant in the reaction with sodium cyanide. The spatial structure of one of the isomer elimination products, 4H-benzo[4,5]imidazo[2,1-b][1,3] thiazine, was established by X-ray structural analysis.
Cracking Optimization of Palmitic Acid Using Fe3+ Modified Natural Mordenite for Producing Aviation Fuel Compounds
Authors:   Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia, Abdulloh Abdulloh , Rahmah Ulfa ,   Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia, Permana Ahmadi Jaya ,   Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia, Mahdy Achmad Affan ,   Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia, Budiastanti Titah Aldila ,   Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia, Fahmi Mochamad Zakki ,   Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia
Published: November 2023

Natural mordenite from Turen village Malang district Indonesia has been modified to Fe3+-mordenite for heterogenous catalyst in cracking process of palmitic acid to produce Aviation fuel components. Cation exchange method has been used in mordenite modification using FeCl3. The Fe3+-mordenite was characterized by structure analysis, Fe content, Si/Al ratio, number of acid sites, pore size, pore volume, and surface area. The catalytic performances, conversion, and selectivity were measured at 583 K by GC-MS for 1, 2, and 3 hours. The high content of Fe in mordenite has larger Brønsted-Lewis’s acid site, pore volume and surface area than the natural mordenite. The crystal structure of Fe3+-mordenite is still the same with natural mordenite. The Fe3+-mordenite also has a smaller pore size than the natural mordenite. In cracking process of palmitic acid, Fe3+-mordenite performed 61.94 % of conversion and 92.90 %, which produced aviation fuel compounds, namely alkanes, alkene, cycloalkane and aromatic.
Penanganan Stunting di Provinsi Sumatera Barat dalam Perspektif Sound Governance
Authors: Ramadhian Fajar Noor , Putri Indah Adi , Ariany Ria , Putera Roni Ekha
Published: November 2023

Even though the SSGI stunting rate decreased from 24.4% in 2021 to 21.6% in 2022, West Sumatra province is one of the provinces in Indonesia with a fairly high stunting rate. One of the cities in West Sumatra which is the largest producer of animal and vegetable food is the city of Padang Panjang. The potential of Padang Panjang City is expected to be able to support the development of the younger generation optimally. However, ironically, around 19% of teenagers still suffered from malnutrition and stunting in Padang Panjang City in 2018. Apart from that, the third area in West Sumatra Province that was designated by Bappenas as a place to care for stunted children, namely Solok Regency. This research uses the concept/theory of good governance according to Ali Farazmand. This research uses a literature review method. This research produces an analysis of the existence of inclusive policies to support the accessibility of district/city areas which have an impact on the potential for economic prosperity. Furthermore, this becomes the axis of health and nutrition development. Finally, there should be policies that produce international synergy in the use of agricultural and fisheries resources which have an influence on the development of health and nutrition in the region.
A Word Attack Skills-Based Program to Enhance EFL Secondary School Students’ Vocabulary Learning, Reading Comprehension and Self-Efficacy
Authors: Ibrahim Ibrahim Elmasry Hamdy
Published: November 2023

The current study aimed at examining the effect of training EFL secondary school students in word-attack skills on enhancing their vocabulary learning, reading comprehension and self-efficacy. Three instruments were developed to achieve the purpose of the study: a vocabulary learning test to measure the participants’ vocabulary development; a reading comprehension test to measure their reading comprehension skills; and a self-efficacy scale to measure their self-efficacy beliefs in vocabulary learning and reading comprehension. The validity and reliability for these instruments were checked before conducting the experiment. The study employed a quasi-experimental design in which the participants were divided into two groups: the control and experimental groups. Each group consisted of 30 female students purposely chosen from second-year secondary school students at Hamza Alsunbati Secondary School, Damietta Governorate. The experimental group received training in word attack skills for 3 months while the control group followed the traditional method of teaching. Results of the study affirmed the effectiveness of training EFL students in these skills revealing significant improvements in the three dependent variables, vocabulary learning, reading comprehension and self-efficacy. Some conclusions and recommendations were reached.
Znaczenie różnych metod pomiaru ciśnienia tętniczego u kobiet w ciąży z nadciśnieniem tętniczym
Authors: Wojciechowska Ewa , Lewandowski Jacek
Published: November 2023

Powikłania nadciśnienia tętniczego w ciąży są najczęstszymi i najistotniejszymi przyczynami zachorowalności i umieralności okołoporodowej zarówno matek, płodów, jak i noworodków. Odpowiadają za blisko 20% zgonów matek i 16% zgonów noworodków na całym świecie. Aby uniknąć powikłań nadciśnienia tętniczego w ciąży, konieczna jest wczesna kontrola ciężarnych, w tym regularne pomiary ciśnienia tętniczego, wczesne wykrywanie choroby nadciśnieniowej i skuteczne jego leczenie. Obecnie najczęściej pomiary ciśnienia wykonywane są w gabinecie, ale w wielu wypadkach zalecane są także pomiary pozagabinetowe. Zaletą tych ostatnich jest możliwość potwierdzenia bądź wykluczenia nadciśnienia, wykluczenia nadciśnienia białego fartucha i nadciśnienia maskowanego oraz w przypadku automatycznego całodobowego pomiaru – sposobność oceny rytmów dobowych ciśnienia. W artykule omówiono znaczenie poszczególnych rodzajów pomiarów ciśnienia u kobiet ciężarnych oraz różnice pomiędzy tymi pomiarami.
Suggested Approach to Solve Nonlinear Ordinary Differential Equations
Authors: A. Hussein Noor , Obaid Firas Jawad
Published: November 2023

In this research a suggested method has been proposed to solve the  non-linear ordinary differential equations, This method is somewhat similar to the Adomain decomposition  method of solving equations but it is quite different in the using steps  to find the non-linear boundaries , in the suggested method does not use an unknown parameter to calculate non-linear boundaries as well as the steps used to calculate non-linear boundaries are very simple and do not need many and complex steps. we can be called this approach by  Fatima style to solve nonlinear ODE.
A new species and a new record of Leioseius Berlese (Acari: Mesostigmata: Ascidae) from Russia, with a review of the Russian species of the genus
Authors: Joharchi Omid , Döker Ismail , Khaustov Vladimir A.
Published: November 2023

A new predatory mite species of the genus Leioseius Berlese, L. subarcticus Joharchi n. sp., is described and illustrated on the basis of morphological characters of adults collected in the subarctic zone of northern Tyumen, from the soil covered with lichens. We also provide additional morphological information and new illustrations for L. changbaiensis Yin and Bei. The species known only from the type series, was found under bark in China (Changbai Mountains, Jilin Province) and is now recorded for the first time in the Altai Republic, Russia, close to type locality from the same habitat. In addition, an identification key to all known Russian species of the genus is presented.
Prognostic value of coronary microvascular dysfunction in patients with aortic stenosis and nonobstructed coronary arteries
Authors: Mohammed Ayman A. , Zhang Hengbin , Li Siqi , Liu Lu , Mareai Redhwan M. , Xu Yawei , Abdu Fuad A. , Che Wenliang
Published: November 2023

Background

Patients with aortic valve stenosis have been postulated to have coronary microvascular dysfunction (CMD) contributing to the clinical symptoms and adverse outcomes. The coronary angiography (CAG)-derived index of microcirculatory resistance (caIMR) is proposed as a novel, less invasive and pressure-wire-free index to assess CMD. This study aimed to quantify CMD assessed by caIMR and investigate its prognostic impact in patients with aortic valve stenosis.

Methods

This study included 77 moderate or severe aortic valve stenosis patients with no obstructive coronary disease (defined as having no stenosis more than 50% in diameter) who underwent caIMR measurement. CMD was defined by caIMR at least 25. Major adverse cardiovascular events (MACE) were the clinical outcomes during the median 40 months of follow-up.

Results

The incidence of CMD was 47.7%. Seventeen MACE occurred during the follow-up duration. CMD was associated with an increased risk of MACE (log-rank P < 0.001) and an independent predictor of clinical outcomes [hazard ratio 5.467, 95% confidence interval (CI) 1.393–21.458; P = 0.015]. The receiver-operating characteristic (ROC) curve analysis demonstrated that caIMR could provide a significant predictive value for MACE in aortic valve stenosis patients (AUC 0.785, 95% CI 0.609–0.961, P < 0.001). In addition, the risk of MACE was higher in CMD patients with severe aortic valve stenosis (log-rank P < 0.001) and no aortic valve replacement (log-rank P = 0.003) than in other groups.

Conclusion

Aortic valve stenosis patients demonstrated markedly impaired caIMR. CMD assessed by caIMR increases the risk of MACE and is an independent predictor of adverse outcomes in aortic valve stenosis patients. This finding suggests that using caIMR in the clinical assessment may help identify high-risk groups and stimulate earlier intervention.
Assessing stakeholders’ opinions on sharing antimicrobial susceptibility testing data from animals is key to developing a centralized database and dashboard tool
Authors: Raineri Raissa R. , Shivley Chelsey B. , Plummer Paul J. , Kreuder Amanda J.
Published: November 2023

OBJECTIVE

To present, analyze, and discuss stakeholders’ opinions regarding sharing antimicrobial susceptibility testing (AST) data from animals into a centralized database and dashboard tool that would collect, aggregate, store, and analyze this type of data from veterinary diagnostic laboratories (VDLs) across the country.

SAMPLE

1 in-person focus group (9 participants), 9 virtual focus groups (49 participants), and online pre- and postmeeting surveys (76 and 35 participants, respectively).

METHODS

Focus groups and surveys were conducted to assess the opinions of veterinarians, producers, researchers, diagnosticians, and government officials.

RESULTS

A strong majority of stakeholders recognize AMR as a serious concern for both human and animal health and see several benefits in establishing a centralized AMR database; however, several concerns were raised associated with data confidentiality, security, curation, and harmonization. In the interest of alleviating those concerns, among other items, stakeholders suggested education and training of data users, providers, and the public in addition to assuring strong data confidentiality protections.

CLINICAL RELEVANCE

Stakeholder engagement is a critical component of all stages of development, implementation, and utilization of an AMR database and dashboard tool that could be used to inform antimicrobial stewardship in veterinary medicine. This assessment of stakeholders’ needs and concerns can be used to help guide future recommendations for data legal protections as well as a data confidentiality and security framework. Maintaining open communication on data usage, storage, and security as well as involvement and education of data providers, users, and the public will remain key to enabling development of an AMR database and dashboard tool for domesticated animals.
Advantages of laparoscopic-assisted ovariohysterectomy versus open ovariohysterectomy for dogs with pyometra not detected in randomized clinical trial
Authors: Brückner Michael , Dörfelt Rene
Published: November 2023

OBJECTIVE

To compare results for surgery time, perioperative pain, need for rescue analgesia, variables, serum C-reactive protein concentration, and postoperative complications for dogs with pyometra treated with laparoscopic-assisted ovariohysterectomy (LaOVH) versus open-surgery (OS) ovariohysterectomy.

ANIMALS

12 client-owned dogs with pyometra between June 1, 2016, and December 31, 2019.

METHODS

Dogs enrolled in this prospective single-center randomized clinical trial had pyometra confirmed by history, physical examination, ultrasonography, and blood work and were randomly assigned to treatment group LaOVH or OS. Differences in results for variables of interest were compared between groups using the Mann-Whitney U test, except the number of dogs requiring rescue analgesia was analyzed using the Fisher exact test. Values of P ≤ .05 were considered significant.

RESULTS

6 dogs were recruited in each group; results for 1 dog in the LaOVH group were excluded from further analysis due to free abdominal fluid detected during surgery. Median surgery time was significantly shorter and median total incision length was longer for the OS group (23 minutes; 106 mm), compared to the LaOVH group (37 minutes; 38 mm). No other results differed significantly between groups.

CLINICAL RELEVANCE

Although fewer patients in the LaOVH group required rescue analgesia, this was not statistically significant. Therefore, our results could not prove previously suggested advantages of LaOVH (eg, less perioperative pain or faster recovery) in dogs with pyometra. Additionally, for the LaOVH group, the median surgical time was approximately 50% longer, an assistant was needed, and specialized equipment was required.
Laparoscopic surgical treatment for sliding hiatal hernia is associated with an owner-perceived improvement in clinical outcome in dogs
Authors: Singh Ameet , Hawker William , Mitchell Krista , Appleby Ryan , Bersenas Alexa , Collier Allison
Published: November 2023

OBJECTIVE

To report perioperative complications and client-perceived outcome following laparoscopic surgical treatment for sliding hiatal hernia (SHH) in dogs.

ANIMALS

Client-owned dogs (n = 9).

METHODS

Medical records were reviewed and perioperative data collected including preoperative diagnostic imaging, operative details, complications, and need for conversion to open celiotomy. A single-incision, multicannulated port was inserted in the subumbilical region followed by placement of an additional 2 or 3 instrument portals. Hiatal plication, esophagopexy, and left-sided gastropexy were performed laparoscopically. Follow-up information was collected with telephone interview with the owners and/or referring veterinarian. A standardized questionnaire was completed by dog owners postoperatively.

RESULTS

Intraoperative pneumothorax occurred in 5 of 9 (55.6%) dogs and resulted in conversion to open celiotomy in 2 (22.2%) dogs. In 4 dogs, pneumothorax was suspected to be the result of progressive leakage of capnoperitoneum through the suture bite holes of the esophageal hiatal plication sutures. Hiatal plication was performed using intracorporeal simple interrupted sutures (n = 4) or a simple continuous pattern with barbed suture (4). Esophagopexy was performed using barbed suture in all dogs. Gastropexy was performed using a total laparoscopic technique (n = 4) or laparoscopic-assisted technique (3). Using a standardized questionnaire, dog owners perceived a postoperative improvement in regurgitation after eating and regurgitation after excitement/increased activity.

CLINICAL RELEVANCE

Laparoscopic treatment of SHH resulted in owner-perceived improvement in clinical signs. Intraoperative pneumothorax occurred in a high proportion of dogs but did not result in long-term sequelae.
The effects of more intensive counseling for disadvantaged unemployed youth
Authors: Eppel Rainer , Mahringer Helmut
Published: November 2023

Many European countries are facing the key challenge of integrating low-skilled jobless young people into the labor market. From 2018 to 2020, the Public Employment Service (PES) in Vienna tested a new model of intensified support (“case management”). The target group consisted of young unemployed persons with low formal qualifications who were drawing on social assistance. Based on the pilot project and a propensity matching approach, we show that the increase in staff significantly increased the intensity of the counseling. It led to an increase in job proposals and active labor market program participation, as well as sanctions in the form of benefit suspensions for failure to keep PES appointments. In line with the goal, more of the young people were encouraged to take part in training and further education instead of being quickly placed in an unskilled job. However, in the three-year follow-up period, the intensified counseling did not (yet) have a significant effect on the overall extent of integration into employment. Regarding post-unemployment job quality, we find no effects on wages at the start of a job.
ST&I Public Policies: A Bibliometric Study of Scientific Production
Authors: De Paulo Richard Coelho , Rabelo Thamiris Thatianne de Araújo , Dias Françoan de Oliveira , Vilela Junior Dalton Chaves , Mafra Rosana Zau
Published: November 2023

Objective: Carry out a bibliometric study of the scientific production on Public Policies for Science, Technology and Innovation (ST&I), in the Web of Science database, in the period from 2013 to 2022.
 
Theoretical framework: Is based on the literature on Public Policies for Science, Technology and Innovation and the history of Public Policies for Innovation in Brazil.
 
Method: This research is classified as descriptive and quantitative. Data were collected from the Web of Science database by accessing the Journal Portal of the Coordination for the Improvement of Higher Education Personnel, with a time frame between January 1, 2013 and December 31, 2022. They were used for data analysis. RStudio® and VOSviewer® software and bibliometric packages Bibliometrix and Biblioshiny.
 
Results and conclusion: 94 documents were identified, with the largest scientific productions on the subject coming from Brazil, China, Spain and Japan. In 2021, it was the year with the most cited documents, followed by 2020. The most cited sources are: Research Policy followed by Technological Forecasting and Social Change. The main co-occurrences of keywords are: science; innovation; technology; innovation policy; and, public policy. With regard to co-authorship between countries, there is a prevalence with China. The most relevant authors on the subject are: [Anonymous] A.; and Alvarez I. Regarding co-citation between authors, there was a prevalence of(e): Organization for Economic Cooperation and Development; Lundvall, B.A.; and, Borras, S. As for the most cited studies globally on the subject in the last ten years at the international level, there are: Padilla-Pérez, R. (2014); Amankwah-Amoah, J. (2016); and Ozkaya, G. (2021). Finally, it is concluded that this study aims to improve the knowledge base on Public Policies for Science, Technology and Innovation and the field of related studies.
 
Search Implications: The main limitation of this search is that it was restricted to the Web of Science, where most of the documents were articles. Therefore, it would be interesting to consider a broader line of research that includes other databases, such as Scopus or Google Scholar, in addition to other types of publications, such as books or conference proceedings.
 
Originality/Value: This study aims to improve the knowledge base on Public Policies for Science, Technology and Innovation and the field of related studies.
PERANCANGAN ANIMASI 2D EDUKASI PENGENALAN FLORA DAN FAUNA DI INDONESIA
Authors: Albani Salmaan Daffa , Rachman Anung , Kurniawan Rendya Adi
Published: November 2023

ABSTRAKIndonesia merupakan negara dengan keanekaragaman flora dan fauna yang terbentang dari Sabang sampai Merauke. Keanekaragaman flora dan fauna yang menakjubkan di Indonesia disebabkan karena letak geografis Indonesia yang terletak di sekitar garis khatulistiwa dan membentang di seluruh pulau-pulau di Indonesia. Selain itu, pengenalan flora dan fauna di kalangan anak-anak masih dinilai rendah karena minimnya inovasi materi. Edukasi tentang pengenalan flora dan fauna kepada anak sangat penting dilakukan untuk melestarikan keberadaan flora dan fauna di Indonesia. Penelitian ini bertujuan untuk menjelaskan konsep proses pembuatan bahan ajar berupa animasi 2D dengan tema mengenalkan anak pada flora dan fauna. Dalam pembuatan animasi 2D ini, metode yang digunakan untuk memecahkan masalah tersebut adalah design thinking yang dipopulerkan oleh Kelley dan Brown. Animasi ini memperkenalkan flora dan fauna di Indonesia dan cara melestarikannya. Diharapkan dengan adanya desain kartun ini, anak-anak dapat belajar tentang keanekaragaman flora dan fauna yang ada di Indonesia untuk menumbuhkan rasa kepedulian mereka terhadap konservasi.ABSTRACTIndonesia is a country with a diversity of flora and fauna that stretches from Sabang to Merauke. The amazing diversity of flora and fauna in Indonesia is due to Indonesia's geographical position which is located around the equator and stretches across all the islands in Indonesia. In addition, the introduction of flora and fauna among children is still considered low due to the lack of material innovation. Education about the introduction of flora and fauna to children is very important to preserve the existence of flora and fauna in Indonesia. This study aims to explain the concept of the process of making teaching materials in the form of 2D animation with the theme of introducing children to flora and fauna. In making this 2D animation, the method used to solve this problem is design thinking which was popularized by Kelley and Brown. This animation introduces the flora and fauna in Indonesia and how to preserve them. It is hoped that with this cartoon design, children can learn about the diversity of flora and fauna in Indonesia to grow their awareness of conservation.
UPAYA PENGENALAN MANAJEMEN PEMASARAN PADA SISWA BINAAN ASAK SATHORA
Authors: Tjokrosaputro Miharni , Lorents Kennt , Angelica Christine
Published: November 2023

Marketing management is a science that may be applied to various sectors. The field of marketing is regarded as one of the business world's spearheads. As a result, high school students should be introduced to marketing management as early as possible so that they comprehend the necessity of marketing management early on. This voluntary work project will teach ASAK Sathora High School students in Jakarta about marketing management. The counseling method was employed in this activity. The implementation of this planned activity will be carried out on Wednesday, 9 November 2022, directly at the St. Thomas Rasul church, Bojong Indah, West Jakarta. This community service activity started with counseling as an effort to introduce ASAK Sathora High School students to Marketing Management in various fields. The output target to be achieved is publication articles/proceedings.

Manajemen Pemasaran adalah salah satu rumpun ilmu yang dapat berguna bagi semua bidang. Pada dunia bisnis, bidang pemasaran dikenal sebagai salah satu ujung tombak dunia usaha. Oleh karenanya, pengenalan tentang manajemen pemasaran sebaiknya dapat diperkenalkan sedini mungkin pada siswa SMA, sehingga siswa SMA dapat memahami pentingnya manajemen pemasaran sejak dini. Program pengabdian masyarakat ini bertujuan untuk memperkenalkan manajemen pemasaran kepada  siswa SMA binaan ASAK Sathora, Jakarta. Metode yang dipakai dalam kegiatan ini adalah metode penyuluhan.  Pelaksanaan kegiatan ini rencananya akan dilaksanakan pada hari Rabu, tanggal 9 November 2022, secara langsung di gereja Santo Thomas Rasul, Bojong Indah, Jakarta Barat. Kegiatan pengabdian kepada masyarakat ini dimulai dari penyuluhan sebagai upaya untuk memperkenalkan siswa SMA Binaan ASAK Sathora  pada Manajemen Pemasaran di berbagai bidang. Target luaran yang akan dicapai adalah artikel publikasi / prosiding.
RANCANGAN USER INTERFACE APLIKASI MOBILE SEBAGAI ALAT BANTU KOMUNIKASI VISUAL ANAK AUTISTIK UNTUK ICT WATCH
Authors: Tony  , Hiryanto Lely , Lie Nadia Natha
Published: November 2023

ICT Watch as a community organization that focuses on collaborative building the capacity of Indonesian human resources for digital literacy knowledge and skills, online expression and cyber governance, has started its movement since 2002. ICT Watch works together with academics from LSPR Jakarta, Center for ASEAN Autism Research, UMN, Code Margonda, and KREAVI have developed a mobile application called VICARA (Visually Interactive Communication and Reading Aid) for autistic children. However, because there was no update, the application was taken down from the Apple Store and Google Play Store. Based on the evaluation results that have been carried out on the use of the VICARA application, ICT Watch intends to redesign and add updates and features to the VICARA application. The solution offered is the development of a user interface (UI) design for the VICARA application.
PENERAPAN KEGIATAN MENYANYI UNTUK MENGEMBANGKAN KONSEP DIRI ANAK PRA-SEKOLAH
Authors: Dariyo Agoes
Published: November 2023

Self-concept is an important term related to the way a person views all aspects of one's own life (physical, cognitive, socio-emotional, and academic aspects. Many children still do not have a positive self-concept due to the influence of a bad family environment, the result is they find it difficult to develop and actualize themselves well in the future.On this basis, community service (PKM) aims to grow and develop the self-concept of pre-school children through singing activities.PKM activities involve kindergarten students Al Hidayah, South Jakarta, using a one group pre-test – post test experimental approach Singing activities using songs specifically designed for the development of self-concept in pre-school children Collecting data using a self-concept questionnaire and given before ( pre-test) and after giving singing activities for 6 meetings (Post-test).Data analysis used the mean test. The results found that singing activities are effective for developing self-concept in pre-school children. Previously, they thought of themselves as children who were ugly, stupid, insecure and lazy. However, after the post-test, they considered themselves as children who were able-bodied, smart, sociable, and diligent.
ABSTRAK
Konsep diri merupakan istilah penting yang terkait dengan cara seseorang memandang terhadap seluruh aspek kehidupan diri-sendiri (aspek fisik, kognitif, sosio-emosional, dan akademik. Banyak anak yang masih belum memiliki konsep diri yang positif karena pengaruh lingkungan keluarga yang tidak baik, akibatnya mereka sulit utuk mengembangkan dan mengaktualisasikan diri dengan baik di masa depan. Atas dasar tersebut, maka pengabdian kepada masyarakat (PKM) bertujuan untuk menumbuh-kembangkan konsep diri anak-anak pra-sekolah melalui kegiatan menyanyi. Kegiatan PKM melibatkan anak-anak siswa TK Al Hidayah Jakarta Selatan, dengan menggunakan pendekatan eksperimen one group pre-test – post test. Kegiatan menyanyi dengan menggunakan lagu-lagu yang dirancang khusus untuk pengembangan konsep diri pada anak-anak pra-sekolah.  Pengumpulan data dengan menggunakan kuesioner konsep diri dan diberikan sebelum (pre-test) dan sesudah pemberian kegiatan menyanyi sebanyak 6 kali pertemuan (Post-test). Analisis data dengan menggunakan uji rerata. Hasilnya ditemukan bahwa kegiatan menyanyi efektif untuk menumbuh-kembangkan konsep diri pada anak-anak pra-sekolah. Sebelumnya, mereka menganggap diri sebagai anak yang bertubuh jelek, bodoh, minder bergaul dan malas. Namun setelah post-test, mereka menganggap diri sebagai anak yang berbadan sehat, pintar, pintar bergaul, dan rajin.
BANTUAN IMPLEMENTASI SOFTWARE AKUNTANSI BAGI KARYAWAN MGK
Authors: Kristian Michelle , Klarisa Livia , Setiyono Stefani Velisia
Published: November 2023

The development of Financial Accounting Standards (SAK) is a framework in the procedure for preparing financial reports so that there is uniformity in the presentation of financial reports. SAK also functions to make it easier for auditors and readers of financial statements to understand and compare the financial statements of different entities, and continue their understanding of knowledge about accounting software that has been given training in the previous semester. The problem faced by MGK is that the results of processing its financial reports are less integrated. The results obtained from this activity are that MGK can use accounting software and produce financial reports that are more accurate and reliable according to Financial Accounting Standards (SAK). so that information from financial reports is less reliable and not timely. In this activity, we provide training assistance and assistance with accounting software implementation.