bluuebunny/crossref_metadata_2025 huggingface dataset:
Influenza A M2 Spans the Membrane Bilayer, Perturbs its Organization and Differentiates the Effect of Amantadine and Spiro[pyrrolidine-2,2'-adamantane] AK13 on Lipids
Authors: Konstantinidi Athina , Chountoulesi Maria , Naziris Nikolaos , Sartori Barbara , Amenitsch Heinz , Mali Gregor , Cendak Tomaz , Plakantonaki Maria , Triantafyllakou Iro , Tselios Theodore , Demetzos Costas , Busath David , Mavromoustakos Thomas , Kolocouris Antonios
Published: July 2019

The investigation and observations made for the M2TM, excess aminoadamantane ligands in DMPC were made using the simpler version of biophysical methods including SDC, SAXS and WAXS, MD simulations and ssNMR. 1H, 31P ssNMR and MD simulations, showed that M2TM in apo form or drug-bound form span the membrane interacting strongly with lipid acyl chain tails and the phosphate groups of the polar head surface. The MD simulations showed that the drugs anchor through their ammonium group with the lipid phosphate and occasionally with M2TM asparagine-44 carboxylate groups. The 13C ssNMR experiments allow the inspection of excess drug molecules and the assessment of its impact on the lipid head-group region. At low peptide concentrations of influenza A M2TM tetramer in DPMC bilayer, two lipid domains were observed that likely correspond to the M2TM boundary lipids and the bulk-like lipids. At high peptide concentrations, one domain was identified which constitute essentially all of the lipids which behave as boundary. This effect is likely due, according to the MD simulations, to the preference of AK13 to locate in closer vicinity to M2TM compared to Amt as well as the stronger ionic interactions of Amt primary ammonium group with phosphate groups, compared with the secondary buried ammonium group in AK13.
Pseudo-Equilibrium Equation of Calcium Phosphate Precipitation from Aqueous Solution
Authors: Fan Hong-Xing , Gou Bao-Di , Gao Yu-Xi , Wu Gang , Zhang Tian-Lan
Published: July 2019

An X-ray amorphous phase is frequently present at the early stage of calcium phosphate crystallization, and the relevant solution chemistry is essential for understanding the mechanism of reaction. Here, we report a quantitative study of a series of reaction systems at pseudo-equilibrium states. We determined the solution compositions and the quantities of the precipitate samples, and characterized the long- and short-range order of the precipitate using X-ray diffraction and synchrotron X-ray absorption near-edge structure spectroscopy respectively. We found that, in a particle containing multiple structural units, only a fraction of the units was able to reach pseudo-equilibrium with the solution composition. This fraction, with its value being determined experimentally, represents the average number of surficial clusters per unit. These findings enabled us to propose a general form of equilibrium constant equation. The equation fits the pseudo-equilibrium data well, and it converts to the “solubility product (Ksp)” and conventional “reaction quotient” in two limit cases, respectively. Further, using a cube model, we derived a “particle equation” that reveals the connection between certain particle parameters and the equilibrium constant equation.
Area-Selective Atomic Layer Deposition of Noble Metals: Polymerized Fluorocarbon Layers as Effective Growth Inhibitors
Authors: Deminskyi Petro , Haider Ali , Eren Hamit , Khan Talha Masood , Biyikli Necmi
Published: July 2019

Selective deposition is a powerful self-aligned precision materials processing strategy which can hugely benefit next-generation nanoelectronics, catalysis, and energy conversion/storage fields. Atomic layer deposition (ALD) is showing a significant promise in enabling area-selective deposition using various growth blocking layers including self-assembled monolayers (SAMs) and various polymers. However, these blocking layers are not compatible with energetic co-reactants like ozone and plasma radicals, showing relatively fast degradation and losing their growth inhibition character. In this work, we demonstrate that polymerized fluorocarbon surfaces function as effective growth inhibitors for ALD-grown Pt and Pd films. Besides effectively inhibiting film growth with considerable nucleation delays for, Pt experiments revealed that polymerized CFx layers are also ozone-compatible. To the best of our knowledge, this is the first demonstration of an AS-ALD process using ozone as co-reactant for noble metals. In our manuscript, we detail our observations of (Pt,Pd) film nucleation evolution and self-aligned deposition experiments on patterned samples. We have performed in-depth chemical and surface characterizations along the nucleation studies and self-aligned patterning experiments.
The miRNAbantamregulates growth and tumorigenesis by repressing the cell cycle regulatortribbles
Authors: Gerlach Stephan U , Sander Moritz , Song Shilin , Herranz Héctor
Published: July 2019

One of the fundamental issues in biology is understanding how organ size is controlled. Tissue growth has to be carefully regulated to generate well-functioning organs, and defects in growth control can result in tumor formation. The Hippo signaling pathway is a universal growth regulator and has been implicated in cancer. InDrosophila, the Hippo pathway acts through the miRNAbantamto regulate cell proliferation and apoptosis. Even though thebantamtargets regulating apoptosis have been determined, the target genes controlling proliferation have not been identified thus far. In this study, we identify the genetribblesas a directbantamtarget gene. Tribbles limits cell proliferation by suppressing G2/M transition. We show thattribblesregulation bybantamis central in controlling tissue growth and tumorigenesis. We expand our study to other cell cycle regulators and show that deregulated G2/M transition can collaborate with oncogene activation driving tumor formation.
Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity
Authors: Matsumura Yuko , Ito Yasuhiko , Mezawa Yoshihiro , Sulidan Kaidiliayi , Daigo Yataro , Hiraga Toru , Mogushi Kaoru , Wali Nadila , Suzuki Hiromu , Itoh Takumi , Miyagi Yohei , Yokose Tomoyuki , Shimizu Satoru , Takano Atsushi , Terao Yasuhisa , Saeki Harumi , Ozawa Masayuki , Abe Masaaki , Takeda Satoru , Okumura Ko , Habu Sonoko , Hino Okio , Takeda Kazuyoshi , Hamada Michiaki , Orimo Akira
Published: July 2019

Emerging evidence supports the hypothesis that multicellular tumor clusters invade and seed metastasis. However, whether tumor-associated stroma induces epithelial–mesenchymal plasticity in tumor cell clusters, to promote invasion and metastasis, remains unknown. We demonstrate herein that carcinoma-associated fibroblasts (CAFs) frequently present in tumor stroma drive the formation of tumor cell clusters composed of two distinct cancer cell populations, one in a highly epithelial (E-cadherinhiZEB1lo/neg: Ehi) state and another in a hybrid epithelial/mesenchymal (E-cadherinloZEB1hi: E/M) state. The Ehi cells highly express oncogenic cell–cell adhesion molecules, such as carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and CEACAM6 that associate with E-cadherin, resulting in increased tumor cell cluster formation and metastatic seeding. The E/M cells also retain associations with Ehi cells, which follow the E/M cells leading to collective invasion. CAF-produced stromal cell-derived factor 1 and transforming growth factor-β confer the Ehi and E/M states as well as invasive and metastatic traits via Src activation in apposed human breast tumor cells. Taken together, these findings indicate that invasive and metastatic tumor cell clusters are induced by CAFs via epithelial–mesenchymal plasticity.
Em cartaz: Hollyfruti. Um estudo da apropriação cultural como estratégia comunicacional da marca Hortifruti
Authors: Kreutz Elizete De Azevedo , Campos Juliane Fröhlic
Published: July 2019

A Rede Hortifruti, maior distribuidora de frutas e verduras do Brasil, com sede no Estado do Espírito Santo, utiliza, em suas campanhas publicitárias, a filmografia hollywoodiana, em consonância com seu discurso multimodal. O objetivo deste estudo é verificar como a utilização de elementos do imaginário coletivo e do cotidiano das pessoas se torna uma importante ferramenta nas estratégias comunicacionais, que geram uma espécie de conexão emocional, ao passar por todas as fases: chamar a atenção do público, instigá-lo pela criatividade e pelo bom humor, interagir com ele e causar a sua identificação com a marca. Para isso, utilizamos a metodologia Hermenêutica de Profundidade, ancorada nas técnicas de pesquisa bibliográfica, entrevista e estudo de caso. Como resultado, esperamos que a pesquisa possa contribuir para a reflexão da importância de consolidar a marca por meio de uma comunicação estratégica e criativa.
Letramento multimodal e texto em sala de aula
Authors: Santos Jardélia Moreira dos
Published: July 2019

Pretendo estabelecer, por meio deste artigo, novas perspectivas para o texto, sob a ótica da Análise de Discurso Crítica (ADC), do Letramento e da Multimodalidade. De acordo com Fairclough (1992, 2001, 2003), Chouliaraki e Fairclough (1999), o entendimento efetivo dos efeitos sociais do texto só é possível se os analisarmos no momento da fala ou da escrita. Kress e van Leeuwen (1996) afirmam que a escrita não mais ocupa o lugar central no panorama comunicacional, por isso, o modo como os professores orientam as práticas discursivas de seus alunos em relação aos textos multimodais pode contribuir para a construção crítica do discurso do aluno. Nesse sentido e, considerando o Letramento, tal qual foi defendido por Street (1984, 1993, 1995), Barton e Hamilton (1998, 2000) e Hasan (1996), proponho uma revisão dessas práticas.
VAN LEEUWEN, T. Discourse and practice: new tools for critical discourse analysis. New York: Oxford University Press, 2008.
Authors: Soares Neiva Maria Machado
Published: July 2019

Em 15 anos, Theo van Leeuwen tem escrito muitos livros e artigos sobre análise do discurso, sobre comunicação visual e sobre multimodalidade. Seu mais recente livro é The language of colour:anintroduction(2011). Atualmente, ele está trabalhando na terceira edição da obra Reading images: the grammar of visual design, com a coautoria de Gunther Kress. Esta obra será publicada em 2013. Ele também é editor da revista Comunicação visual2.A obra constitui um aparato metodológico, como o próprio nome sugere, que visa a contribuir para a análise de textos escritos ou visuais. Perpassa campos que vão desde a sociologia, àAnálise de Discurso Crítica (ADC) e à Teoria Semiótica Social da Multimodalidade (TSSM). Divide-se em nove capítulos,constituindo-se por um corpus analítico variado (livros infantis, reportagens, fotografias e brinquedos) sobre práticas do contexto escolar. Essa diversidade contribui para a análise de como as práticas sociais podem ser transformadas em discursos.
Individual deprivation, regional deprivation, and risk for oral clefts in Argentina
Authors: Pawluk Mariela Soledad , Campaña Hebe , Rittler Monica , Poletta Fernando Adrián , Cosentino Viviana R. , Gili Juan Antonio , Gimenez Lucas Gabriel , López Camelo Jorge Santiago
Published: July 2019

Objective. The aim of this study was to analyze the effects of individual low socioeconomic status (SES) and deprived geographical area (GA) on the occurrence of isolated cleft lip with or without cleft palate (CL±P) in Argentina.

Methods. This case-control study included 577 newborns with isolated CL±P and 13 344 healthy controls, born between 1992 and 2001, from a total population of 546 129 births in 39 hospitals in Argentina. Census data on unsatisfied basic needs were used to establish the degree of geographical area deprivation. An SES index for each individual was established, using maternal age, gravidity, low paternal and maternal education, and low-level paternal occupation. Logistic regression was used to assess the effects of low SES and of deprived GA on CL±P.

Results. A slightly increased risk of CL±P was observed in mothers with a low SES, while a deprived GA showed no effect. Native ancestry, acute maternal illnesses, and poor prenatal care were significant risk factors for CL±P for the mothers with low SES, after using propensity scores to adjust for the demographic characteristics in cases and controls.

Conclusions. Low individual SES slightly increased the risk for CL±P, but a deprived GA did not have that effect. There was no interaction between individual SES and deprived GA. Factors related to low individual SES—including poor prenatal care, low parental education, lack of information, and lifestyle factors—should be primarily targeted as risk factors for CL±P rather than factors related to a deprived place of residence.
Monitoring modifiable risk factors for breast cancer: an obligation for health professionals
Authors: Guerra Guerrero Verónica , Fazzi Baez Antonieta , Cofré González Carmen Gloria , Miño González Carmen Gloria
Published: July 2019

Worldwide, breast cancer is the most common disease in women and constitutes the second leading cause of cancer death in this population. The factors that contribute to the risk of occurrence are divided into nonmodifiable and modifiable factors. Although there are interventions in primary care to prevent the disease, these measures have not produced the desired changes in women’s health. This article reviews the major modifiable risk factors for breast cancer and describes how these factors can affect the incidence of cancer in women. This information shows that modifiable risk factors (such as physical activity, diet, obesity, and use of alcohol and tobacco) can influence the occurrence of breast cancer, in part depending on the life stage of a woman, including menopausal status. Timely prevention at the primary care level is one of the most important areas on which health professionals need to focus in order to help reduce the incidence of breast cancer.
Leptospirosis in Latin America: exploring the first set of regional data
Authors: Schneider Maria Cristina , Leonel Deise Galan , Hamrick Patricia Najera , Caldas Eduardo Pacheco de , Velásquez Reina Teresa , Mendigaña Paez Fernando Antonio , González Arrebato Jusayma Caridad , Gerger Andrea , Maria Pereira Martha , Aldighieri Sylvain
Published: July 2019

Objectives.To demonstrate the importance of country surveillance systems for leptospirosis and their use for preliminary epidemiological analysis, as well as to generate research questions for future, morecomprehensive studies on the disease.

Methods.In 2015, for the first time, the Pan American Health Organization (PAHO) included human cases of leptospirosis in its Regional Core Health Data Initiative, an open-access database that collects annual health indicators from the countries and territories of the Americas. This new information was used to analyze leptospirosis cases by country and sex and to calculate cumulative incidence rates. Maps were used to help present the results. To supplement that general review of leptospirosis in the Americas, more detailed descriptions of the epidemiological situation and the surveillance programs of four selected countries (Brazil, Colombia, Cuba, and Honduras) were provided.

Results.In this first year of PAHO requesting leptospirosis data, of the 49 countries and territories in the Americas, 38 of them (77.6%) reported information. Among those 38, 28 of them (73.7%) reported the presence of human cases; the majority of instances of zero cases were in Caribbean territories. From those 28, a total of 10 702 human cases were recorded. The largest numbers of cases in Latin America were in Brazil (40.2%), Peru (23.6%), Colombia (8.8%), and Ecuador (7.2%). The cumulative incidence rate for Latin America was estimated to be 2.0 per 100 000 population. On average, 65.1% of cases were males.

Conclusions.This study demonstrates that many countries in Latin America are making efforts to establish strong surveillance systems and programs for leptospirosis. The study also shows the importance of having leptospirosis surveillance systems as well as how the information generated can be used for evidence-based decision-making on leptospirosis.
A review of the quality of current diabetes clinical practice guidelines
Authors: Barcelo Alberto , Jawed Muzamil , Qiang Anthony , the PAHO Diabetes Guideline Project Group
Published: July 2019

Objective To obtain an evaluation of current type 2 diabetes mellitus (T2DM) clinical practice guidelines.

Methods Relevant guidelines were identified through a systematic search of MEDLINE/PubMed. Pan American Health Organization (PAHO) country offices were also contacted to obtain national diabetes guidelines in use but not published/available online. Overall, 770 records were identified on MEDLINE/PubMed for citations published from 2008 to 2013. After an initial screening of these records, 146 were found to be guidelines related to diabetes. Inclusion and exclusion criteria were used to further refine the search and obtain a feasible number of guidelines for appraisal. Guideline evaluation was conducted by health professionals using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument, which was developed to address the issue of variability in guideline quality and assesses the methodological rigor and transparency in which a guideline is developed. A total of 17 guidelines were selected and evaluated.

Results Ten guidelines scored ≥ 70% and seven guidelines scored ≥ 80%. The range was 21%–100%. The mean scores for Latin America and the Caribbean (LAC) country guidelines (n = 6) were compared to the mean scores for non-LAC country guidelines (n = 11). International guidelines consistently scored notably higher in all domains and overall quality than LAC guidelines.

Conclusions Based on this study’s findings, it is clear that T2DM clinical practice guideline development requires further improvements, particularly with regard to the involvement of stakeholders and editorial independence. This issue is most apparent for LAC country guidelines, as their quality requires major improvement in almost all aspects of the AGREE II criteria. Continued efforts should be made to generate and update high-quality guidelines to improve the management of increasingly prevalent noncommunicable diseases, such as T2DM.
Escenario futuro de la diabetes mellitus tipo 2 estimado con un modelo de simulación dinámico predictivo
Authors: Gutiérrez-Enríquez Sandra Olimpia , Gaytán-Hernández Darío , Díaz-Oviedo Aracely , González-Acevedo Claudia Elena , Miranda-Herrera Magdalena , Hernández-Ibarra Luis Eduardo
Published: July 2019

Objetivo. Desarrollar un modelo dinámico predictivo para estimar escenarios futuros de la tasa de incidencia de diabetes mellitus tipo 2 (TIDM2).

Métodos. Se realizó un estudio ecológico retrospectivo durante el periodo 2013-2015 en la ciudad de San Luis Potosí, México. Se analizaron datos oficiales secundarios de los 58 municipios que integran el estado de San Luis Potosí. Se aplicó la correlación lineal, la regresión lineal múltiple, ecuaciones estructurales, y se desarrollaron cuatro submodelos dinámicos predictivos: TIDM2, población urbana, viviendas particulares habitadas que cuentan con televisión y población de 45-49 años de edad. Se desarrolló también un modelo holístico.

Resultados. El modelo estructural explica 27,2% del total de la varianza de la diabetes mellitus tipo 2. El porcentaje de viviendas habitadas que cuentan con televisión pesan 4,46 unidades no estándar sobre la diabetes, el de población urbana, 2,84 y el de población de 45-49 años, 156,69. Los escenarios estimados de la TIDM2 por 100 000 habitantes, para los años 2015, 2020, 2025 y 2030 fueron 1 052,4, 1 413,7, 1 850,1 y 2 351,1 respectivamente.

Conclusión. El escenario de la TIDM2 muestra un crecimiento exponencial del año 2000 al 2030. Los factores de riesgo según el peso que representan para la ocurrencia de la enfermedad fueron: población de 45-49 años, viviendas particulares habitadas que cuentan con televisión y población urbana.
Hospital-based tuberculosis control activities in five cities of Latin America
Authors: Moreno Ralfh , López Rafael , Tenorio Alfonso , Victoria Jorge , Volz Anna , Cruz Oscar , Moreno Ernesto , Quijada Carlos , Hesse-de-Herrera Ana , Aguirre Sarita , Santos Laedi , Lima Noemi , Tanomaru Neide , Alarcon Antonieta , Del-Granado Mirtha
Published: July 2019

Objective. To generate actionable insights for improving TB control in urban areas by describing the tuberculosis (TB) control activities of hospitals in five cities in Latin America.

Methods. A descriptive study of hospital-based TB control activities was conducted in 2013–2015 using a cross-sectional survey designed by the Pan American Health Organization and administered in Guatemala City, Guatemala; Guarulhos, Brazil; Bogotá, Colombia; Lima, Peru; and Asunción, Paraguay. Data were analyzed using Chi-squared, Fisher exact tests, and the Mantel–Haenszel test for Risk Ratios, as necessary (P < 0.05).

Results. While variation among cities existed, most hospitals (91.3%) conducted acid-fast bacilli smears for TB diagnosis and had a quality control process (94.0%), followed national TB guidelines (95%), and reported TB cases to the respective health authorities (96%). Additionally, TB treatment was offered free of charge almost universally (97.1%). However, only 74.2% of hospitals were supervised by the national or local TB programs; 52.8% followed up on the outcome of referrals; and 39.1% offered full ambulatory TB treatment, with 68.7% using Directly-Observed Therapy.

Conclusion. The study underscored strengths and weaknesses in specific areas for TB control activities in hospitals and highlighted the importance and complexity of coordinating efforts among private and public hospitals and the various stakeholders. Local TB programs and health authorities should use these results to enhance the quality of TB-related actions in hospitals in similar settings.
Selección y adaptación: el tratado polémico De fide contra Manichaeos en diálogo con los adversarios maniqueos de Agustín
Authors: Vanspauwen Aäron
Published: July 2019

De fide contra Manichaeis (Sobre la fe, contra los maniqueos) es un tratado polémico contra los maniqueos atribuido a Evodius de Uzalis, contemporáneo y amigo de Agustín. Las fuentes más importantes del De Fide son los escritos antimaniqueos de Agustín. Este artículo sitúa la argumentación del De fide en el amplio marco de las polémicas entre los maniqueos y la Iglesia “católica” africana hacia el final del siglo IV y el inicio del siglo V. En particular, se ilustra cómo el De fide utiliza los testimonios maniqueos proporcionados por Agustín. En un capítulo introductorio, el artículo considera varias preguntas históricas significativas en torno al tratado. Subsecuentemente, se introducen los debates entre Agustín y sus adversarios maniqueos. En la tercera y más importante sección del artículo se estudian varios argumentos clave del debate entre católicos y maniqueos, y cómo el De Fide responde específicamente a los testimonios maniqueos en su argumentación. La conclusión ofrece una evaluación crítica del propósitodel De fide en tanto compendio paradigmático de argumentos antimaniqueos. El análisis comparativo realizado por este artículo profundiza la comprensión de los siguientes aspectosde la Iglesia africana de la Antigüedad tardía. Primero, revela el modus operandi y las preocupaciones de los predicadores maniqueos en su intento por apelar a una identidad cristiana. Segundo, su investigación acerca de la selección de los argumentos provenientes de la obra de Agustín ilustra la recepción de los trabajos polémicos (antimaniqueos) de este por un texto patrístico de su tiempo. Aunque, en general, el ejemplo de Agustín es seguido de manera más bien fiel, De fide efectivamente fue una oportunidad para corregir o complementar sus afirmaciones previas. Tercero, la eficiencia o, al contrario, la futilidad del De fide y de la empresa antimaniquea de Agustín pueden ser evaluadas.
Pelagianismo como una novedad en Agustín de Hipona
Authors: Malavasi Giulio
Published: July 2019

Agustín luchó en contra de los pelagianos por más de dos décadas, desde 411 hasta su muerte en 430, cuando dejó su inacabado y último trabajo contra Julián de Aeclanum. Durante este largo periodo, Agustín se opuso al movimiento pelagiano, principalmente, a través de tratados teológicos y sermones. En este artículo, dichas fuentes serán analizadas desde la perspectiva retórica: en particular, observaremos varios fragmentos en los cuales Agustín tilda el movimiento pelagiano de novedad, una técnica retórica que le abre varias posibilidades para atacarlo. Estas tácticas retóricas específicas en contra del pelagianismo están orientadas hacia, al menos, tres objetivos: primero, Agustín identifica claramente sus propias enseñanzas, con la comunidad verdaderamente católica enraizada en la antigua tradición de la fe; segundo, Agustín desacredita definitivamente a su enemigo, pues los sitúa completamente por fuera de la antigua tradición de la Iglesia, ya que representan una novedad sin ninguna conexión con la verdadera y antigua fe; tercero, Agustín difunde entre su audiencia la doctrina del pecado original, que, al menos según él, concuerda perfectamente con la tradición de la Iglesia. Todas esas cuestiones serán exploradas en este artículo.
La lectura no polémica de Agustín de Fil. 2:6-7
Authors: Irizar Pablo
Published: July 2019

El uso de Agustín de Filipenses 2:6-7 como la “regla de la fe” que le sirve para quitarle importancia a las preocupaciones de la cristología pronicea ha sido, correctamente, enfatizado repetidamente por parte de los expertos agustinólogos anglófonos. Empero, el énfasis en la polémica función del dueto forma servi/forma dei ha hecho que se pierda de vista su presencia y desarrollo en contextos no polémico. Esto es sorprendente dado que Agustín trata bastante más frecuentemente la perícopa en cuestión por fuera de contextos polémicos. El presente artículo tiene por objetivo completar este vacío catalogando los usos no polémicos de Filipenses 2:6-7 en el trabajo de Agustín y su desarrollo vis-à-vis del término forma entre los predecesores latinos inmediatos del siglo IV de Agustín. Así, este artículo espera ilustrar el sentido no polémico, frecuentemente ignorado, de Filipenses 2:6-7 dentro del discurso del cristianismo temprano.
Reflexiones sobre la “trans-formación” de la universidad mediante la transdisciplinariedad en prácticas docentes e investigación
Authors: Córdoba María Elena
Published: July 2019

En educación superior resulta evidente la necesidad de un cambio en los planes y estrategias que los docentes implementan en sus prácticas, una renovación capaz de atender la complejidad en la que vivimos y que contemple la protección de la sociedad y el medioambiente como elementos de prioridad en el quehacer de los futuros profesionales, de manera que puedan responder congruentemente a las problemáticas actuales. La necesidad de cambio no es un descubrimiento de los últimos años, es un tema que ha estado en discusión por mucho tiempo, sin embargo, los esfuerzos e iniciativas para transitar a un nuevo modelo han resultado poco efectivos o insuficientes. El modelo educativo fundamentado en diseños estructurados exclusivamente con disciplinas desligadas unas de otras dificulta dar una respuesta integral a las complejas problemáticas sociales que se nos presentan. Por ello, las instituciones de educación superior se plantean la superación del paradigma educativo tradicional, que involucra la enseñanza separada en disciplinas (asignaturas), para dar paso a modelos transdisciplinarios que abarcan varias disciplinas en forma transversal; no solo de nombre o con retoques a lo existente, sino hacia un enfoque que pueda trascender con un salto cualitativo. La transformación implica que desde las aulas se asuma la enseñanza abordando el sujeto u objeto de estudio de manera que se integren las diversas dimensiones y áreas del saber que lo componen, a fin de posibilitar una comprensión lo más cercana a la complejidad del mismo. Para lograrlo, debe abrirse el diálogo para la trans-formación de la educación superior, escuchando diferentes voces, no solo académicas, y que incluya todos los niveles y actores involucrados en la educación superior. La propuesta de esta reflexión sugiere la transdisciplinariedad como una forma de lograr esta transformación.
DETERMINANTS OF ABANDONED HOUSING PROJECTS IN MALAYSIA
Authors: Abdul-Razak Dzuljastri
Published: July 2019

The issues of abandoned housing projects are not new in Malaysia.Without proper measures to tackle, they will continue to haunt homebuyers. This study examines responses of 328 customersobtained bymeans of self-administered questionnaires. Four variables namelylack of justice and equity, methods of computing and pricing, natureof contract and lack of legal and governance were used as variables.The results indicated that all the hypothesized relationships aresupported. Of these, the nature of contract was found to be the maincause of the problem. The results contributes to the scanty empiricalresearch in this area. It also benefits managers of Islamic banksto address issues that are affectingabandoned housing projects inMalaysia.
CORPORATE SOCIAL RESPONSIBILITY OF ISLAMIC BANK'S PRACTICES: AN EXPLORATORY STUDY
Authors: Jusoh Wan Noor Hazlina Wan , Ibrahim Uzaimah
Published: July 2019

The purpose of this paper is to explore the corporate social responsibility (CSR) practices of an Islamic bank, which is Bank Islam Malaysia Berhad (BIMB). This research used face-to-face interview technique as a research method in order to get data that are more accurate. The data analysis focuses on four CSR themes namely, zakat, charitable activities, employee and environment. The findings show that BIMB has applied CSR practices in various ways and does not merely focussing on zakat and charitable activities as debated in previous studies in other Islamic banks. This paper contributes to the growing debate on CSR among Islamic financial institutions especially in Islamic banking industry by exploring new visibilities.
MODEL OF HUMAN RESOURCE PERFORMANCE IMPROVEMENT BASED ON HUMAN CAPITAL AND SOCIAL CAPITAL WITH THE MODERATION OF INFORMATION TECHNOLOGY
Authors: Ningrum Budiarti
Published: July 2019

This study investigates the effect of human capital and social capital on human resource performance, and the moderating effect of information technology. Based on a total sample of 88 respondents from the Technical Implementation Unit (UPT) of Monitor Radio Frequency Spectrum Class I Semarang and Yogyakarta which is analyzed using structural equation modeling based smartPLS 3.0, the results indicated that 1) human capital is positively related to social capital and human resorce performance; 2) social capital is positively related to human resorce performance; 3) information technology moderates the relationships between social capital and human resorce performance; and 4) information technology moderates the relationships between human capital and human resource performance.Keywords: Human capital, Social capital, Information technology, Human resource performance
EMPLOYEE PERFORMANCE IMPROVEMENT THROUGH RELIGIOUS VALUES AND QUALITY OF COMMUNICATIONS AS WELL AS PERSONAL INTEGRITY (Case Study in PoLSUSKA Daop 5 Purwokerto)
Authors: Zahid Achmad
Published: July 2019

The purpose of this study is to examine a model in which religious values and communication quality predict personal integrity and employee� performance.� A� total� of� 129� respondents fromPolsuska Daop 5 Purwokertocompleted questionnaires. Results from structural equation modeling based smartPLS 3.0 confirmed that religious values and communication quality were positively related to personal integrity and employee performance. Furthermore, the result revealed that personal integrity was positively related to employee performance. Keywords: Religious values, Communication quality, Personalintegrity, Employee performance
IMPROVING PROFESSIONAL COMPETENCE AND KNOWLEDGE SHARING BASED ON ORGANIZATIONAL CITIZENSHIP BEHAVIOR TOWARD HUMAN RESOURCES PERFORMANCE
Authors: Rika Agustina Maulidatur , Nurhayati Tatiek
Published: July 2019

This study aims to describe and analyze the effect of organizational citizenship behavior on HR performance with professional commitment and knowledge sharing as an intervening variable. The population used is the total number of employees of local water company (PDAM) Semarang total of them are 569 people, with a total sample of 85 people. The sampling technique is Proportional Random Sampling. The analysis tool is Partial Least Square. Another test result shows that OCB has a positive effect on professional competence. The test proves that OCB and professional competencies have a positive effect on knowledge sharing. Organizational citizenship behavior, professional competence and knowledge sharing have a positive effect on HR performance. The test results show that professional competence is able to be an intervening variable between OCB and knowledge sharing, while professional competence is not able to be an intervening variable between OCB and HR performance. Knowladge sharing is able to be an intervening variable between OCB and HR performance and knowledge sharing can also be an intervening variable between professional competence and HR performance.Keywords:�� �Organizational citizenship behavior, professional commitment and knowledge sharing and performance of Human Resources
TRADISI PENGANUGERAHAN IJAZAH DALAM SISTEM PENDIDIKAN ISLAM: KAJIAN SELAYANG PANDANG
Authors: Idriz Mesut , Nurhamidah Idha
Published: July 2019

The current article aimed at presenting an overview of types, requirements and procedures of certification in Islam education for the students who have passed the examination in order for countries outside United Arab Emirates. Core materials on the subject were compiled from various resources to guarantee the validity of the information. It turned out that there were a number of concepts of certification pertinent to etymology and practices. One distinctive issue of certification was that, in Islam education, certification was attached to the authority of professor or sheikh, not the institution, and the government has no right whatsoever with respect to certification. This, in fact, differentiates certification in Islam World from that practiced in the West.Keywords: Certificate, Certification, Etymological Concept, Islam Education System
PEMANFAATAN KERJA SAMA INDONESIA-JEPANG ECONOMIC PARTNERSHIP AGREEMENT (IJEPA) DAN INDONESIA – PAKISTAN PREFERENTIAL TRADE AGREEMENT (IPPTA)
Authors: Ningsih Endah Ayu , Falianty Telisa Aulia , Budiarti Fitri Tri
Published: July 2019

AbstrakPenelitian ini mengevaluasi tingkat pemanfaatan Indonesia-Japan Economic Partnership Agreement (IJEPA) dan Indonesia-Pakistan Preferential Trade Agreement (IPPTA) dalam ekspor dan impor Indonesia ke Jepang dan Pakistan. Tingkat pemanfaatan FTA untuk ekspor menggunakan rasio nilai perdagangan yang termuat dalam Surat Keterangan Asal (SKA) terhadap nilai ekspor ke negara mitra. Sedangkan tingkat pemanfaatan impor menggunakan rasio nilai impor produk yang memenuhi syarat terhadap total impor Indonesia dari negara mitra. Studi ini menemukan bahwa pemanfaatan IJEPA (2012-2016) cenderung menurun. Pada tahun 2016 tingkat pemanfaatan ekspor sebesar 47,2%. Sementara pemanfaatan IPPTA untuk ekspor ke Pakistan mengalami peningkatan yang signifikan sejak diimplementasi tahun 2013 dengan tingkat pemanfaatan ekspor sebesar 72,0% pada tahun 2016. Di sisi impor pemanfaatan IJEPA mencapai 67,7% sementara IPPTA hanya 18,8% (2016). Pemanfaatan impor IJEPA dan IPPTA relatif stagnan, jumlah perusahaan yang menggunakan SKA IJEPA sudah pada level jenuh, sementara pengguna SKA IPPTA masih tumbuh 18,2% per tahun. Bentuk PTA lebih memberikan dampak positif bagi peningkatan ekspor Indonesia ke negara mitra dibandingkan FTA yang komprehensif. Kebijakan melakukan FTA dalam bentuk Economic Partnership perlu disertai dengan kerja sama yang menjamin peningkatan perdagangan yang seimbang antar negara anggota. AbstractThis study aims to address the utilization level of The Indonesia-Japan Economic Partnership Agreement (IJEPA) and Indonesia-Pakistan Preferential Trade Agreement (IPPTA). The level of FTA utilization for exports was measured by the ratio of trade value recorded in the Certificate of Origin (CoO) to Indonesia’s export value to the related country. While the level of utilization of imports was defined by the ratio of the import value of eligible products to Indonesia's total imports from the related country. The study found IJEPA’s utilization during 2012-2016 tended to decrease. In 2016, the level of utilization was about 47.2%. While IPPTA utilization for exports to Pakistan experienced a significant increase since it was implemented in 2013 with a rate of export utilization was 72.0% in 2016. On the import side, the level of utilization under IJEPA reached 67.7% while IPPTA was only 18.8% at the same period. In terms of the imports utilization level of both IJEPA and IPPTA, it was relatively stagnant, while the number of companies utilize IJEPA’s CoO was saturated. In contrast, IPPTA’s CoO users still grew at 18.2% per year. This study concluded PTA provides more positive impact on increasing Indonesia's exports to related countries than comprehensive FTAs. Thus, establishing an FTA in the form of an Economic Partnership needs to be followed with the cooperation that guarantees trade balance within the parties.
DAMPAK KERJA SAMA PERDAGANGAN INDONESIA DENGAN EURASIAN ECONOMIC UNION (EAEU) TERHADAP PEREKONOMIAN INDONESIA
Authors: Paryadi Deky , Salam Aziza Rahmaniar
Published: July 2019

Abstrak Kawasan Eurasia merupakan wilayah yang penting secara geopolitik dan geostrategi bagi perdagangan Indonesia. Melihat potensi yang dimiliki oleh negara-negara yang tergabung dalam Eurasian Economic Union (EAEU), Indonesia diharapkan dapat memanfaatkan peluang yang terbuka. Penelitian ini bertujuan untuk mengetahui potensi daya saing komoditas serta dampak kerja sama perdagangan Indonesia-EAEU. Metode analisis yang digunakan adalah Trade Complementary Index (TCI), Revealed Symetric Comparative Advantages (RSCA) dan Computable General Equilibrium (CGE) model dengan data dasar GTAP versi 9 menggunakan enam simulasi. Berdasarkan analisis TCI, tingkat kesesuaian ekspor EAEU terhadap struktur impor Indonesia lebih tinggi dibandingkan ekspor Indonesia terhadap struktur impor EAEU. Dengan melihat dampak kerja sama perdagangan Indonesia-EAEU terhadap makroekonomi Indonesia, penurunan tarif bea masuk sebesar 50% untuk seluruh produk Indonesia dan EAEU merupakan alternatif kebijakan terbaik. Indonesia perlu menjajaki kemungkinan kerja sama dengan EAEU dengan pendekatan berupa eliminasi 50% pada seluruh pos tarif secara bertahap. Selain itu, disarankan Indonesia fokus pada komoditas yang memiliki daya saing di pasar EAEU yaitu sektor animal; vegetable; foodstuffs; plastics/ rubber; raw hides; woods; textile; stone/glass; machinery; dan transportation.AbstractThe Eurasian region is an important area for Indonesia in term of geopolitic and geostrategy. Due to the economic potential of EAEU countries, Indonesia must take advantage of it. This study aims to determine the potential competitiveness of commodities and the impact of trade cooperation between Indonesia-EAEU. Methods used in this study were Trade Complementary Index (TCI), Revealed Symetric Comparative Advantages (RSCA) and Computable General Equilibrium (CGE) model utilizing basic data of GTAP version 9 of six simulations. By using TCI method it was found that the comformity level of EAEU's export to Indonesia's import structure is higher than Indonesia's exports to the EAEU import structure. Looking at the impact of Indonesia-EAEU trade cooperation on Indonesia’s economy, tariff reduction of 50% for all Indonesian products and EAEU is the best policy alternative for Indonesia. Therefore, It is a must to Indonesia to explore the possibility of cooperation with EAEU with a 50% elimination scheme gradually to all tariff lines. Indonesia should also focus on commodities which have competitiveness in EAEU market i.e. animal; vegetable; foodstuffs; plastics/rubber; raw hides; woods; textile; stone/glass; machinery; and transportation.
PENGEMBANGAN PASAR EKSPOR LADA INDONESIA
Authors: Nurhayati Ely , Hartoyo Sri , Mulatsih Sri
Published: July 2019

AbstrakSalah satu komoditas yang dapat dimanfaatkan untuk meningkatkan kinerja ekspor Indonesia sebagai negara agraris adalah lada. Penelitian ini bertujuan untuk menganalisis pasar potensial untuk ekspor lada yang bisa dikembangkan, serta mengetahui faktor-faktor yang memengaruhi ekspor komoditas lada. Penelitian ini menggunakan metode RCA, EPD, X-Model, dan Gravity Model. Hasil analisis dengan menggunakan model RCA, EPD, dan X-model menunjukkan bahwa ‘pasar optimis’ untuk dikembangkan adalah Belanda. Sedangkan ‘pasar potensial’ untuk dikembangkan adalah Malaysia, Vietnam, Korea Selatan, Rusia, Prancis, Belgia, Jerman, dan Amerika Serikat. Sementara itu hasil analisis dengan menggunakan model Gravity menunjukkan bahwa faktor-faktor yang memengaruhi ekspor adalah domestik bruto per kapita, populasi, harga ekspor, jarak ekonomi dan tarif. Oleh karena itu, pemerintah perlu mempertimbangkan faktor-faktor yang memengaruhi ekspor lada untuk mengembangkan pasar ekspor. Faktor tersebut diantaranya menjaga stabilitas harga ekspor, memilih pasar dengan Produk Domestik Bruto (PDB) per kapita yang tinggi, populasi yang besar dan cenderung meningkat, serta memiliki jarak ekonomi dan tarif yang kecil dan cenderung menurun. AbstractPepper is one of agricultural commodities that has significant export value for Indonesia. The study aims to analyze the potential market for pepper exports that can be developed, and the factors that influence pepper commodity exports. This research used RCA, EPD, X-Model, and Gravity Model methods. Using the RCA, EPD, and X-model the study indicated that ‘the optimistic market’ to be developed was the Netherlands. While ‘the potential markets’ to be developed were Malaysia, Vietnam, South Korea, Russia, France, Belgium, Germany and the United States. Using the Gravity model, it was confirmed factors affected export were gross domestic product per capita, population, export prices, economic distance and tariffs. This study recommends that the Government needs to consider the following factors including the stability of export prices, a market with high Dross Domestic Product (GDP) per capita and a large population which tends to increase, and a small economic distance and tariff that tends to decline.
Topraktan İzole Edilen Bacillus Türlerinden α-Amilazın İzolasyonu ve Karakterizasyonu
Authors: KAYA Sedat , ENEZ Barış
Published: July 2019

Toprak

mikroflorasının önemli bir kısmı Bacillus

cinsi bakterilerden oluşur. Bu bakterilerden elde edilen amilazların daha fazla

stabilite, yüksek verimlilik ve düşük üretim maliyetine sahip olma gibi

özellikleri vardı. Bundan dolayı topraktan izole edilen Bacillus cereus WYS01, Bacillus

thuringiensis VITLW1, Bacillus

thuringiensis ES2I3P, Bacillus cereus

TG16 mikroorganizmalardan α-amilazın izolasyonu ve karakterizasyonunu

gerçekleştirilmiştir. Yapılan araştırmada bütün bakterilerin maksimum enzim

üretiminin 36. saatte, pH 7.0 ve 40 ºC’de olduğu tespit edildi.

Mikroorganizmalar arasında spesifik aktivitesi en yüksek olan Bacillus cereus WYS01’tur. Enzim

aktivitesine sıcaklık ve pH gibi önemli etkisi olan parametrelere bakıldı. Bacillus thuringiensis VITLW1, Bacillus thuringiensis ES2I3P ve Bacillus cereus TG16 bakterilerinin 40

ºC de, Bacillus cereus WYS01’in ise

60 ºC de maksimum aktiviteyi gösterdiği tespit edildi. Bütün mikroorganizmalar

en fazla pH7.0 da α-amilaz aktivitesini gerçekleştirdi. Bu çalışmada

endüstriyel ve biyoteknolojik yönden önemi olan amilazın bakteriler tarafından

elde edildiği belirlendi.
Biology and Laboratory Rearing of Codling Moth, Cydia pomonella (L.) (Lepidoptera: Tortricidae) on Its Natural Host “Green Immature Apple” Malus domestica (Borkh) (Rosales: Rosaceae)
Authors: KUYULU Akın , GENÇ Hanife
Published: July 2019

The

codling moth, Cydia pomonella Linnaeus, 1758 (Lepidoptera: Tortricidae) is an economically

important pest of apple trees in Turkey and also in worldwide. The aim of this

study was to report a continuous rearing method on green immature apples (Malus domestica cv. 'Gala') for C. pomonella and fundamental information

of its biology. The experiments were conducted from 2017 to 2019 under the

laboratory conditions. Eggs were laid individually or disorderly in small

masses on the oviposition substrate in the adult cages. Adult food had a

positive effect on the number of eggs laid per female and egg viability. Larvae

developed through five instars based on head capsule measurements. Larval development

was completed in 15.89±0.25 days. Survival rate of larvae ranged from 24.1% and

92.6% based on larval density per apple. The duration of pupal development was

8.90±0.10 days with 87.5% adult emergence. The life cycle was completed on

average in 29.5±0.3 days. Adult longevity was 12.2±0.60 days for

females and 16.7±1.90 days for males. A single female laid about 12.3 eggs/day

and a total of 85-200 eggs with 83.9% viability. The codling moth has been reared continuously in the laboratory for two years

with no evidence of disease in the colony.
Arazi Toplulaştırma Projelerinde Parsel Şekillerinin Değişimi: Şanlıurfa Bozca Köyü Örneği
Authors: DEĞİRMENCİ Hasan , ARSLAN Fırat , KETEN Mualla
Published: July 2019

Tarımsal

işletmelerin parçalı arazilerini bir araya getirmek, parsel şekillerini

düzeltmek, yol ve sulama olanaklarını sağlamak amacıyla arazi toplulaştırma

(AT) çalışmaları yürütülmektedir. Bugüne kadar yaklaşık 6 milyon ha alanda

arazi toplulaştırma çalışması tamamlanmış olup, Tarım ve Orman Bakanlığı

tarafından 2023 yılına kadar 14 milyon hektar alanda AT projelerinin

tamamlanması hedeflenmektedir. Arazi toplulaştırma projelerinin tarımsal

işletmelere sağladığı önemli yararlarından biri parsel şekillerinin

düzeltilmesidir. Parsel şekillerinin AT öncesi ve sonrası değişimi birçok

araştırmacı tarafından sayısal göstergelerle ifade edilmektedir. Fraktal büyüklük indeksi (FD), şekil

indeksi (SI), şekil faktörü (FORM),  alan

şekil faktörü (AFF), kare piksel ölçeği (SqP) ve alan çevre oranı (APR) parsel şekillerinin tarıma uygunluğunu ölçmek amacıyla yaygın olarak

kullanılan göstergelerdir. Bu çalışmada Şanlıurfa ili Viranşehir ilçesi Bozca

köyü AT projesi materyal olarak alınmıştır. Proje alanı 1159.22 ha’dır. Arazi

toplulaştırma öncesi parsel sayısı 101 iken, proje sonrası 159’a çıkmıştır.

Parsel sayısının artması hisseliliğin azalmasından kaynaklanmaktadır. Bu

çalışmanın amacı AT öncesi ve sonrası parsel şekillerinin değişimini şekil

indeks göstergeleri ile karşılaştırmaktır. Çalışmada şekil indeks

göstergelerini sınıflandırmak ve haritalar oluşturmak amacıyla NetCAD 5.0 ve

ArcMAP 10.5 haritalama programları kullanılmıştır. Yapılan analiz sonuçlarına

göre; AT öncesi ortalama FD, SI, FORM, AFF, SqP, ve APR değerleri sırasıyla

3.07, 1.45, 0.54, 0.04, -0.81 ve 5.147; AT sonrası

ise 1.30, 1.42, 0.55, 0.04, -0.82 ve 5.04 olarak hesaplanmıştır. AT

öncesi ve sonrası FD, SI ve APR indeks değerleri arasında istatiksel olarak

anlamlı bir fark bulunmuştur (P<0.05). Ancak diğer indeks değerleri arasında

istatistiksel olarak önemli seviyede fark bulunmamıştır. Sonuç olarak parsel

şekillerinin AT öncesi ve sonrası durumda parsel büyüklüklerinin azalmasına

rağmen parsel şekillerinde önemli seviyede bir değişim olmadığı görülmüştür.