bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypoxic high-intensity interval training in individuals with overweight and obesity
Authors: Ghaith Abdallah , Chacaroun Samarmar , Borowik Anna , Chatel Lisa , Doutreleau Stéphane , Wuyam Bernard , Tamisier Renaud , Pépin Jean-Louis , Flore Patrice , Verges Samuel
Published: September 2022

Combining moderate-intensity exercise training with hypoxic exposure may induce larger improvement in cardiometabolic risk factors and health status compared with normoxic exercise training in obesity. Considering the greater cardiometabolic effects of high-intensity intermittent training (HIIT), we hypothesized that hypoxic high-volume HIIT (H-HIIT) would induce greater improvement in cardiorespiratory fitness and health status despite a lower absolute training workload than normoxic HIIT (N-HIIT) in overweight/obesity. Thirty-one subjects were randomized to an 8-week H-HIIT [10 male and 6 female; age: 51.0 ± 8.3 years; body mass index (BMI): 31.5 ± 4 kg·m−2] or N-HIIT (13 male and 2 female; age: 52.0 ± 7.5 years; BMI: 32.4 ± 4.8 kg·m−2) program (3 sessions/week; cycling at 80% or 100% of maximal workload for H-HIIT and N-HIIT, respectively; target arterial oxygen saturation for H-HIIT 80%, [Formula: see text] ∼0.12, i.e., ∼4,200 meters above sea level). Before and after training, the following evaluations were performed: incremental maximal and submaximal cycling tests, pulse-wave velocity, endothelial function, fasting glucose, insulin, lipid profile, and body composition. Maximal exercise (V̇o2peak: H-HIIT +14.2% ± 8.3% vs. N-HIIT +12.1 ± 8.8%) and submaximal (ventilatory thresholds) capacity and exercise metabolic responses (power output at the crossover point and at maximal fat oxidation rate) increased significantly in both groups, with no significant difference between groups and without other cardiometabolic changes. H-HIIT induced a greater peak ventilatory response (ANOVA group × time interaction F = 7.4, P = 0.016) compared with N-HIIT. In overweight/obesity, the combination of normobaric hypoxia and HIIT was not superior for improving cardiorespiratory fitness improvement compared with HIIT in normoxia, although HIIT in hypoxia was performed at a lower absolute training workload.
Developmental oxygen preadapts ventricular function of juvenile American alligators, Alligator mississippiensis
Authors: Crossley Janna L. , Lawrence Tyler , Tull Melissa , Elsey Ruth M. , Wang Tobias , Crossley Dane A.
Published: September 2022

Developmental oxygen is a powerful stressor that can induce morphological and functional changes in the cardiovascular systems of embryonic and juvenile vertebrates. This plasticity has been ascribed, at least in part, to the unique status of the developing cardiovascular system, which undergoes organogenesis while meeting the tissue oxygen demands of the embryo. We have previously reported an array of functional and morphological changes in embryonic American alligators that persist into juvenile life. Most notably, cardiac enlargement as well as functional parameters of anesthetized juvenile alligators remains after embryonic hypoxic exposure. Because the effects of developmental oxygen in crocodilians have only been investigated in anesthetized animals, we explored the pressure dynamics of both ventricles as well as systemic pressure in response to stressors of acute hypoxia and swimming. Our current findings demonstrate that developmental programming of cardiac function (intraventricular pressure and heart rate) does persist into juvenile life, but it is chamber-specific and depends on the experimental manipulation. Acute hypoxic exposure revealed that juvenile alligators that had experienced 10% O2 as embryos maintain right ventricle function and increase left ventricle function during exposure. Finally, the data indicate blood flow in the left aorta must originate from the left ventricle during acute hypoxia and swimming.
Hypertension depresses arterial baroreflex control of both heart rate and cardiac output during rest, exercise, and metaboreflex activation
Authors: O’Leary Donal S. , Mannozzi Joseph , Augustyniak Robert A. , Ichinose Masashi , Spranger Marty D.
Published: September 2022

Rapid regulation of arterial blood pressure on a beat-by-beat basis occurs primarily via arterial baroreflex control of cardiac output (CO) via rapid changes in heart rate (HR). Previous studies have shown that changes in HR do not always cause changes in CO, because stroke volume may vary. Whether these relationships are altered in hypertension is unknown. Using the spontaneous baroreflex sensitivity (SBRS) approach, we investigated whether baroreflex control of HR and CO were impaired after the induction of hypertension in conscious, chronically instrumented canines at rest, during mild exercise, and during exercise with metaboreflex activation (induced via reductions in hindlimb blood flow) both before and after induction of hypertension (induced via a modified Goldblatt approach—unilateral reduction in renal blood flow to ∼30% of control values until systolic pressure ≥ 140 mmHg and a diastolic pressure ≥ 90 mmHg for >30 days). After induction of hypertension, SBRS control of both HR and CO was reduced in all settings. In control, only about 50% of SBRS changes in HR caused changes in CO. This pattern was sustained in hypertension. Thus, in hypertension, the reduced SBRS in the control of HR caused reduced SBRS control of CO and this likely contributes to the increased incidence of orthostatic hypotension seen in hypertensive patients.
Increased spleen volume provoked by temperate head-out-of-water immersion
Authors: Keeler Jason M. , Hess Hayden W. , Tourula Erica , Baker Tyler B. , Kerr Payton M. , Greenshields Joel T. , Chapman Robert F. , Johnson Blair D. , Schlader Zachary J.
Published: September 2022

This study tested the hypotheses that 1) spleen volume increases during head-out-of-water immersion (HOWI) and returns to pre-HOWI values postdiuresis, and 2) the magnitude of apnea-induced spleen contraction increases when preapnea spleen volume is elevated. Spleen volume was measured before and after a set of five apneas in 12 healthy adults (28 ± 5 yr, 3 females) before, during (at 30 and 150 min), and 20 min after temperate temperature (36 ± 1°C) HOWI. At each time point, spleen length, width, and thickness were measured via ultrasound, and spleen volume was calculated using the Pilström equation. Compared with pre-HOWI (276 ± 88 mL), spleen volume was elevated at 30 (353 ± 94 mL, P < 0.01) and 150 (322 ± 87 mL, P < 0.01) min of HOWI but returned to pre-HOWI volume at post-HOWI (281 ± 90 mL, P = 0.58). Spleen volume decreased from pre- to postapnea bouts at each time point ( P < 0.01). The magnitude of reduction in spleen volume from pre- to postapneas was elevated at 30 min of HOWI (−69 ± 24 mL) compared with pre-HOWI (−52 ± 20 mL, P = 0.04) but did not differ from pre-HOWI at 150 min of HOWI (−54 ± 16 mL, P = 0.99) and post-HOWI (−50 ± 18 mL, P = 0.87). Thus, spleen volume is increased throughout 180 min of HOWI, and whereas apnea-induced spleen contraction is augmented after 30 min of HOWI, the magnitude of spleen contraction is unaffected by HOWI thereafter.
Evaluation Method of Product Shape Features based on Multidimension Spatial Data Mining
Authors: Liu Feilong , Li Miao
Published: September 2022

Analysis of product shape design has attracted more and more attention of researchers because it can make products better meet perceptual needs. Based on the theory of spatial data mining, this study proposes an evaluation method of a product shape design scheme. The method proposed in this study not only obtains the shape design of the overall and local features of the product, which solves the problem of the insufficient utilization of spatial data by the analysis method. During the simulation process, the model obtains the product shape design and appeal from the online evaluation spatial data, which can integrate the product perceptual knowledge in the spatial data, which greatly reduces the manual operation steps and the required time for the degree of data utilization. The experimental results show that after the obtained data are filtered to extract the feature words, the weight of the feature words is calculated by the TF-IDF method, the number of neighbors is increased from 1 to 30, the interval is 5, and the vectorized representation of the spatial data is constructed. The similarity between the calculation sentences of the data mining method is 89.7%, which effectively improves the support function and design efficiency of spatial data mining for product design.
The Application of Multimedia Visualization Platform in Business Management from the Perspective of Supply Chain Management
Authors: Wang Nuan
Published: September 2022

At present, in the process of enterprise operation and development, the implementation of enterprise operation modernization is a necessary condition and an effective measure to raise the management level. With the aim to achieve such enterprise modernization, it is necessary to improve the management’s modernization ability by improving the modernization level of enterprises. Therefore, corporate executives should pay more attention to the construction of informatization and implement informatization through effective methods and measures to further improve management efficiency. It will note the concept and connotation of business management, analyze the significance of the multimedia visualization platform at the level of enterprise business supply chain, analyze the current business management of enterprises and put forward scientific coping strategies, cater to the social development situation, and constantly innovate the development path of enterprise network information and chemical business management; this will help related majors.
Prognostic Analysis of LncRNA MCM3AP‐AS1 in Colorectal Cancer and the Mechanism of Its Effect on Tumor Cell Activity
Authors: Song Qi , Gao Jinsuo , Yang Jinzhu , Gopinath Subash C. B. , Shen Lei
Published: September 2022

To determine the clinical prognostic significance of lncRNA MCM3AP‐AS1 in colorectal cancer (CRC) and its preliminary mechanism, 43 CRC patients and 48 healthy individuals were analyzed. Peripheral blood MCM3AP‐AS1 was quantified via qRT–PCR in CRC patients at admission and 2 h after surgery and in healthy individuals. Human colon cancer cells (HCT116 and SW480) were transfected with shRNAs targeting upregulation of MCM3AP‐AS1 expression (named as sh‐MCM3AP‐AS1 group) and corresponding negative RNAs (named as sh‐MCM3AP‐AS1 group). Additionally, the cells were then treated either with 50 mM of the VEGF‐specific inhibitor PTK787 (Selleck, USA) (named as inhibition group) or normal saline as a control (named as control group). Before therapy, CRC patients presented a higher MCM3AP‐AS1 level than healthy individuals (P < 0.05), and the sensitivity and specificity of MCM3AP‐AS1 in predicting the occurrence of CRC were 65.12% and 83.33%, respectively (P < 0.001). After therapy, CRC patients presented a decrease in MCM3AP‐AS1 levels, and recurrence was higher in patients who died (P < 0.05). Additionally, the high MCM3AP‐AS1 expression group presented a higher mortality than the low MCM3AP‐AS1 expression group (P < 0.05). In an in vitro assay, CRC cells showed a higher MCM3AP‐AS1 level than CCD‐18Co cells, and the sh‐MCM3AP‐AS1 group presented decreased cell proliferation and invasiveness, whereas the levels apoptosis‐associated proteins were increased (P < 0.05). Moreover, the VEGF and VEGFR2 mRNA levels were increased in CRC cells, and VEGF/VEGFR2 pathway‐associated proteins were inhibited in the sh‐MCM3AP‐AS1 group (P < 0.05). Moreover, treatment with PTK787 decreased cell proliferation and invasivness but increased the levels of apoptosis‐associated proteins (P < 0.05).
An Intelligent Robot Detection System of Uncontrolled Radioactive Sources
Authors: Zhuang Jianyou , Zheng Guibing
Published: September 2022

In recent years, radioactive sources have been widely used in various fields (e.g., nuclear industry, agriculture, medical industry, environmental protection, and scientific research) and successfully applied to develop scientific projects, such as nuclear power generation, sewage treatment, medical diagnosis, and new material development. However, radiation sources continuously got out of control and even lost. Manual search for uncontrolled radiation sources is inefficient and prone to radiation injuries. Therefore, it is practically significant to design a radiation source detection robot. Against this backdrop, this study designs an intelligent robot detection system of uncontrolled radiation sources and develops an intelligent robot for detecting and disposing of uncontrolled radiation sources. The research results help to realize the autonomous search and disposal of radiation sources.
Research on Intelligent Multimedia Distance Teaching System considering Virtual Reality Technology
Authors: Zeng Yi
Published: September 2022

With the continuous growth of the social economy, teaching methods are constantly innovating and changing, from the traditional subjective single teaching mode to the new teacher-student interactive teaching mode supplemented by various network resources, but there are still some influencing factors in these teaching modes. In view of these deficiencies and needs, for the purpose of addressing the issues of the traditional teaching model such as lack of timeliness, inaccuracy, and high energy consumption, the virtual reality (VR) technology is applied to the intelligent multimedia distance teaching system. Combining the existing teaching requirements and the frame structure of the multimedia distance teaching system design, the hardware and software systems of the system are designed, respectively. User login can be realized through software and hardware system design. Through teaching resources, teaching management, and other functions, the VR technology can be used to complete the reasonable allocation of multimedia teaching resources to enhance multimedia teaching quality effectively. Finally, the test results are analyzed. Compared with other teaching systems, the proposed intelligent multimedia distance teaching system can lower the transmission energy and signal-to-noise ratio (SNR) of teaching resource data effectively, which is of certain practical value.
Analysis of the Impact of Financial Structure Evolution on Economic Growth and Management Efficiency
Authors: Zuo Zhouwei
Published: September 2022

Under the development of social economy and the gradual improvement and optimization of the financial and economic system, China’s financial structure is constantly changing and evolving. Financial institutions are the interrelations and connections between the various parts of the economy as a whole. They represent the role and achievements of the financial economy. Research shows that the transformation and evolution of financial structure promotes economic development and management efficiency. Therefore, under the background of the continuous evolution of financial structure, this article explores the factors of the evolution of financial structure on economic growth and management efficiency. The results of the experiment are as follows: (1) this article investigates developments of the evolution of financial structure, economic development, and management efficiency, determines the research direction of the experiment, provides background support for the subject research of this paper, and explores the influencing factors according to the impact mechanism on economic development and management efficiency and (2) put the evolution background of the financial structure in the degree of economic development and management efficiency. By using the economic growth calculation algorithm and management efficiency calculation algorithm, calculate the change trend of the range of economic growth and the fluctuation of the degree of management efficiency under the background of the evolution of the financial structure. The experimental results show that under the background of the evolution of the financial structure, the total development of the national economy has been effectively broken through, and the management mode of enterprises has been improved to effectively improve the management efficiency.
A Corpus-Based Study on the Employment of Verb Keep between St3 and St4 in CLEC and Brown
Authors: Zhang Ning
Published: September 2022

The present paper focuses on the frequently used verb keep by Chinese non-English majors and native speakers based on three corpora, namely, Brown, St3, and St4 in CLEC. Brown stands for a corpus of native speakers, whereas St3 and St4 in CLEC stand for Chinese non-English majors who take CET-4 and CET-6 tests, respectively. This paper employs the contrastive analysis theory. The thesis investigates the commonly used keep senses by Chinese learners in CLEC compared with those senses in Brown by native speakers. This current research also employs a large amount of computer instruments like SPSS, AntConc, Microsoft Excel, and Wordsmith. Furthermore, the research aims to find out whether Chinese learners’ performance on verb keep gets improvement with the promotion of their English proficiency. The results of the paper show that Chinese non-English majors do not have a good command of the frequently used senses of keep by native speakers. There exists overuse and underuse of some senses. Nevertheless, with the improvement of English proficiency, Chinese learners’ employment of keep is becoming much closer to that of the native speakers. According to the research, some pedagogical reflections to improve English teaching and learning of verbs like keep are also discussed in the paper. Blended teaching can be applied before class, and microlectures can be provided online. Keep phrasal verbs, idioms, and collocations can be included in microlectures, while class teachers and students can collaboratively draw mind maps of verb keep. After class, more assignments can be provided online, such as multiple choice, blank filling, translation, and so on.
Identification of Interleukin-1-Beta Inhibitors in Gouty Arthritis Using an Integrated Approach Based on Network Pharmacology, Molecular Docking, and Cell Experiments
Authors: Zeng Liying , Lin Zekun , Kang Pan , Zhang Meng , Tang Hongyu , Li Miao , Xu Kun , Liu Yamei , Jiang Ziyun , Huo Shaochuan
Published: September 2022

Background. This study aimed to investigate the molecular mechanism of Tongfengding capsule (TFDC) in treating immune-inflammatory diseases of gouty arthritis (GA) and interleukin-1-beta (IL-1β) inhibitors by using network pharmacology, molecular docking, and cell experiments. Methods. In this study, the compounds of TFDC and the potential inflammatory targets of GA were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Online Mendelian Inheritance in Man (OMIM), and GeneCards databases. The TFDC-GA-potential targets interaction network was accomplished by the STRING database. The TFDC-active compound-potential target-GA network was constructed using Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used to further explore the GA mechanism and therapeutic effects of TFDC. Quantitative real-time PCR (qPCR) was used to verify whether the TFDC inhibited IL-1β in GA. Molecular docking technology was used to analyze the optimal effective compounds from the TFDC for docking with IL-1β. Result. 133 active compounds and 242 targets were screened from the TFDC, and 25 of the targets intersected with GA inflammatory targets, which were considered as potential therapeutic targets. Network pharmacological analysis showed that the TFDC active compounds such as quercetin, stigmasterol, betavulgarin, rutaecarpine, naringenin, dihydrochelerythrine, and dihydrosanguinarine had better correlation with GA inflammatory targets such as PTGS2, PTGS1, NOS2, SLC6A3, HTR3A, PPARG, MAPK14, RELA, MMP9, and MMP2. The immune-inflammatory signaling pathways of the active compounds for treating GA are IL-17 signaling pathway, TNF signaling pathway, NOD-like receptor signaling pathway, NF-kappa B signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, etc. The TFDC reduced IL-1β mRNA expression in GA by qPCR. Molecular docking results suggested that rutaecarpine was the most appropriate natural IL-1β inhibitor. Conclusion. Our findings provide an essential role and bases for further immune-inflammatory studies on the molecular mechanisms of TFDC and IL-1β inhibitors development in GA.
3,5-Dinitrobenzoate and 3,5-Dinitrobenzamide Derivatives: Mechanistic, Antifungal, and In Silico Studies
Authors: Duarte Allana B. S. , Perez-Castillo Yunierkis , Andrade Patrícia Néris , de Castro Ricardo D. , de Sousa Damião P.
Published: September 2022

Fungal infections, including those caused by Candida spp., are recognized in immunocompromised individuals for their high rates of morbidity and mortality. Microorganism resistance to conventional drugs compromises treatment effectiveness and yet also reveals the need to develop new drugs. In many compounds, nitro groups contribute to antimicrobial activity; thus, the inhibitory activity of a collection of twenty esters and amides (derived from 3,5-dinitrobenzoic acid) against Candida spp. was elucidated using microdilution methods to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicide Concentration (MFC), as well as probable mechanisms of action. The structures of the synthesized compounds were characterized by FTIR spectroscopy, 1H-NMR, 13C NMR, and HRMS. Of the tested derivatives, ten presented fungicidal activity against at least one of the tested strains. Ethyl 3,5-dinitrobenzoate (2) exhibited the most potent antifungal activity against Candida albicans (MIC = 125 µg/mL; 0.52 mM), Candida krusei (MIC = 100 µg/mL; 4.16 mM), and Candida tropicalis (MIC = 500 µg/ml; 2.08 mM). The structure of the second most potent derivative (propyl 3,5-dinitrobenzoate (3) reveals that esters with short alkyl side chains exhibit better biological activity profiles. Compounds 2 and 3 presented a mechanism of action involving the fungal cell membrane. Though compound 2 modeling against C. albicans revealed a multitarget antifungal mechanism of action, involving various cellular processes, interference in the synthesis of ergosterol was observed. Our results demonstrate that certain ester derivatives containing aromatic ring nitro groups may be useful in the search for new antifungal drugs.
Comprehensive Analysis of the Role of SLC2A3 on Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma
Authors: Chu Manru , Zheng Ke , Li Xiaojie , Luo Zhiqiang , Yang Xin , Wei Changbo
Published: September 2022

Background. SLC2A3 is upregulated in various cancer types and promotes proliferation, invasion, and metabolism. However, its role in the prognosis and immune regulation of head and neck squamous cell carcinoma (HNSCC) is still obscure. This study is aimed at exploring the prognostic and immunotherapeutic potential of SLC2A3 in HNSCC. Methods. All data were downloaded from TCGA database and integrated via R software. SLC2A3 expression was evaluated using R software, TIMER, CPTAC, and HPA databases. The association between SLC2A3 expression and clinicopathologic characteristics was assessed by R software. The effect of SLC2A3 on survival was analyzed by R software and Kaplan-Meier Plotter. Genomic alterations in SLC2A3 were investigated using the cBioPortal database. Coexpression of SLC2A3 was studied using LinkedOmics and STRING, and enrichment analyses were performed with R software. The relationship between SLC2A3 expression and immune infiltration was determined using TIMER and TISIDB databases. Immune checkpoints and ESTIMATE score were analyzed via the SangerBox database. Results. SLC2A3 expression was upregulated in HNSCC tissues compared to normal tissues. It was significantly related to TNM stage, histological grade, and alcohol history. High SLC2A3 expression was associated with poor prognosis in HNSCC. Coexpression analysis indicated that SLC2A3 mostly participated in the HIF-1 signaling pathway and glycolysis. Furthermore, SLC2A3 expression strongly correlated with tumor-infiltrating lymphocytes in HNSCC. Conclusion. SLC2A3 could serve as a potential prognostic biomarker for tumor immune infiltration in HNSCC.
The Pretreatment of Xiaoqinglong Decoction Alleviates Inflammation and Oxidative Damage and Up-Regulates Angiotensin-Converting Enzyme 2 in Lipopolysaccharide-Induced Septic Acute Lung Injury Rats
Authors: Su Jing-Chao , Cheng Chen , Wang Cai-Yun , Zhang Yi , He Ya-Ting , Guo Zi-Wei , Liu Xin-Yue , Liu Wen-Mei , Zhang Yu-Jie , Xu Shu-Wen , Zhang Xin-Yue , Liu Zi-Bing , Zhang Xin-Fang
Published: September 2022

Xiaoqinglong decoction (XQLD), a classic prescription of Traditional Chinese Medicine, has already been used clinically to cure acute lung injury (ALI), but its mechanism remains unclear. This subject aimed to explore the preventive role of XQLD in septic ALI rats besides its effects on angiotensin-converting enzyme (ACE)2 and its downstream factors. After, respectively, administrated with different concentrations of XQLD (6.25 g/kg/d, 12.5 g/kg/d, 25 g/kg/d) for 5 days and dexamethasone (DEX, 1 mg/kg) for 0.5 h, the rat models of ALI were established by intraperitoneal injection of lipopolysaccharide (LPS, 5 mg/kg) for 24 h. All rats were evaluated by lung function test, arterial blood gas analysis, morphological observation, lung wet/dry (W/D) ratio, and the lung injury score. The levels of malonaldehyde (MDA), superoxide dismutase (SOD), interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and angiotensin (Ang) (1–7) in the lung were measured through biochemical and ELISA kits. The expressions of angiotensin-converting enzyme (ACE)2, mitochondrial assembly receptor (MasR), and nuclear factor (NF)-κB in lung tissue were detected by qRT-PCR and western blotting. Positive reaction cells of MasR were observed by immunohistochemistry. The results show that XQLD significantly ameliorated septic lung injury including edema and hemorrhage, as well as improved pulmonary function and arterial blood gas. Furthermore, XQLD markedly decreased the levels of IL-1β, TNF-α, MDA, and NF-κB while increased the levels of SOD, Ang (1–7), ACE2, and MasR in septic ALI rats. Pearson correlation showed that the expressions of ACE2 were inversely related to IL-1β, TNF-α, MDA, and NF-κB and positively correlated with SOD contents. Our data indicated that XQLD pretreatment alleviated inflammation and oxidative damage in septic ALI rats, which might be related to the up-regulation of ACE2-Ang (1–7)-MasR axis and inhibition of the NF-κB pathway.
Application of Improved DEA Algorithm in Public Management Problem Classification
Authors: Li Jialin
Published: September 2022

In order to effectively solve the related problems in the process of public management, this research proposes an improved algorithm technology based on Data Envelopment Analysis (DEA) and classification algorithm. With the help of lever management, this paper further solves and overcomes the problem of DEA algorithm itself and the defect of “relative effectiveness.” At the same time, in order to avoid the impact on the input and output indicators, with the help of principal component analysis, taking the performance evaluation of public management departments as the research direction, this paper makes an empirical analysis on the performance evaluation of public management departments. The evaluation results of the index system show that the correlation coefficient between the efficiency value of the initial index system and the efficiency value of optimization 2 is 0.977759, and the correlation coefficient is less than 0.7. The evaluation results are more reasonable than those before the improvement.
UAV-Assisted Sensor Data Dissemination in mmWave Vehicular Networks Based on Network Coding
Authors: Huang Shidong , Huang Chuanhe , Wu Dongfang , Yin Yabo , Ashraf M. Wasim Abbas , Fu Bin
Published: September 2022

Due to good maneuverability, UAVs and vehicles are often used for environment perception in smart cities. In order to improve the efficiency of sensor data sharing in UAV-assisted mmWave vehicular network (VN), this paper proposes a sensor data sharing method based on blockage effect identification and network coding. The concurrent sending vehicles selection method is proposed based on the availability of mmWave link, the number of target vehicles of sensor data packet, the distance between a sensor data packet and target vehicle, the number of concurrent sending vehicles, and the waiting time of sensor data packet. The construction method of the coded packet is put forward based on the status information about the existing packets of vehicles. Simulation results demonstrated that efficiency of the proposed method is superior to baseline solutions in terms of the packet loss ratio, transmission time, and packet dissemination ratio.
Lifetime-Maximized Strong Barrier Coverage of 3D Camera Sensor Networks
Authors: Hong Yi , Luo Chuanwen , Li Deying , Chen Zhibo , Wang Xiyun
Published: September 2022

Camera sensor networks (CSNs) have advantages on providing the precise and multimedia information for plenty of applications. The high coverage quality of CSNs especially satisfies the monitoring requirements of barrier coverage. In three-dimensional (3D) application scenarios, the tracking of the potential intruder in the monitored irregular spaces brings more difficulties and challenges on strong barrier coverage for CSNs. In this paper, we consider the strong barrier coverage problem in 3D CSNs and focus on the objective of monitoring the intruder with high resolution and maximizing the network lifetime. We firstly introduce the definition and hardness proof for the problem based on the irregular space model and the network model, which adopts the Region of Interest (ROI) sensing model with high effective resolution. Secondly, we design two sleep-and-awake scheduling algorithms for the problem in homogeneous and heterogeneous networks, respectively, which are based on the auxiliary graph transformation and the disjoint flows construction. To evaluate these algorithms’ performance on the lifetime maximization, we conduct extensive simulation experiments and analyze their results on their advantages and applicable scenarios.
[Retracted] Clinical Application of Peritoneal Dialysis Catheterization without Capsular Puncture Technique
Authors: Wei Zhifeng , Han Xiaoli , Zhi Yunxia , Liu Junfen , Pan Xing , Liu Shengjun
Published: September 2022

Objective. To summarize the advantages of peritoneal dialysis (PD) catheters without capsular puncture (only one pneumoperitoneum needle) puncture technique conducted by our center. Methods. The study examines the clinical data of PD patients (including the general situation of patients, intraoperative and postoperative characteristics, and complications) undergoing pneumoperitoneum needle catheterization from January 2019 to May 2021 in the Department of Nephrology at the First Affiliated Hospital of Hebei North University (the largest peritoneal dialysis center in Zhangjiakou). Results. A total of 153 surgical cases were collected. There were 91 males and 62 females. The mean (± standard deviation) age was 56.1 ± 18.6 years, and the mean (± standard deviation) follow‐up time was 16.7 ± 8.2 months. The average operation time was 30.33 minutes with a standard deviation of 14.80 minutes. The length of abdominal incision is 2.38 ± 0.42 cm, and the blood loss was about 26.3 ± 9.2 ml, including 2 cases of laparoscopic reposition of drift tube, 0 case of pipe blockage, 3 cases of fluid leakage, 1 case of peritoneal dialysis catheter tunnel infection, 4 cases of outlet infection, 12 occurrences of peritonitis, 121.3 patient months in peritonitis, and 0 times in omentum wrapping without bladder injury, incisional hernia, or intestinal injury. Conclusion. Relative to open operation, the peritoneal dialysis (PD) catheters with pneumoperitoneum needle puncture technique has the following advantages: simpler operation, shorter operation time, less bleeding, less injury, less complications, and higher safety. Moreover, there are no additional costs compared with open operation. Thus, the technique is recommended for clinical applications.
Optimisation of Working Line Length during the Period of Gently Inclined Slope in Tilted Coal Seam Open-Pit Mine
Authors: Cao Bo , Zhao Bo , Wang Shuai , Lv Mingjia , Li Qingyi , Liu Guangwei
Published: September 2022

In the initial production phase of an inclined seam opencast mine, due to initial investment and production capacity constraints, zoning or phasing is usually used, resulting in changes in the length of the working line during the transition of the mining area. To simplify the process, this article analyses the changes in the length of the working line during the period of slow gang steering in inclined seam opencast mines. In order to simplify the process, this article analyses the changes in the length of the working line in each period. The relationship between the length of the working line and the realm stripping ratio in the overlapping area of the two mining areas is discussed, and the variation in the realm stripping ratio and the economically reasonable stripping ratio under different working line lengths is illustrated. The advantages and disadvantages of the different optimization options are described. The optimization method was applied to the Zhundong opencast coal mine to calculate the working line lengths for the two stages. The optimized stripping ratio for the second-stage south gang location is equal to the economically reasonable stripping ratio of 3.50 m3/t, which reduces coal compression and improves economic efficiency, and is a guideline for the study of the working line lengths in each stage of the open-pit mine slow gang turning.
A New Certificateless Signcryption Scheme for Securing Internet of Vehicles in the 5G Era
Authors: Cui Beibei , Wei Lu , He Wei
Published: September 2022

The application of digital signature technology to the Internet of vehicles (IoV) is affected by its network and communication environment. In the 5G era, the influx of a large number of intelligent devices into the mobile Internet requires a low transmission delay and power consumption as well as high-security requirements. To the best of our knowledge, a well-designed solution in which signcryption technology is used has not been proposed in the IoV research area. Motivated by the fact, a certificateless signcryption scheme based on the elliptic curve digital signature algorithm, in which pseudonym and timestamp mechanism are also considered, has been designed in this paper. We prove that the scheme proposed by us can be reduced to solving the difficulty of the computational Diffie–Hellman problem with a standard model, showing that the scheme meets requirements on both security and efficiency, which provides a comparative analysis with the state-of-the-art schemes in terms of security analysis, computational cost, and communication cost, demonstrating that the scheme proposed by us is suitable to be deployed in the IoV environment, which is of the characteristics of high-speed vehicle movement.
Differential Scanning Calorimetry Material Studies: Benzil Melting Point Method for Eliminating the Thermal History of DSC
Authors: Zhu Ziyang , Li Wei , Yin Yilin , Cao Ruilin , Li Zenghe
Published: September 2022

How to eliminate the thermal history present in differential scanning calorimetry, this question has been widely concerned. Benzil has a serious thermal history that is not well eliminated by conventional thermal history methods. Herein, using benzil as a target, we developed a freeze-gradient temperature rate heating up method to eliminate the thermal history of DSC. Compared with the conventional method, this method avoids the introduction of new thermal histories by new crystalline forms that may appear during the cooling crystallization process. The results show that the peak shape of the melting peak is sharper and the peak emergence position is closer to the theoretical melting point after the elimination of the thermal history by the freeze-gradient heating up method. Based on this method, we optimized other factors to establish a complete method for the determination of melting point by DSC, analyzed the uncertainty of the method, and obtained an extended uncertainty of 0.19°C for DSC in this method. The validation results show that the p-nitrotoluene of the melting point reference substance was 52.64°C, which is within its reference value of (52.53 ± 0.20) °C, showing that this method is reliable. This study provides a reference for other thermal analysis methods to eliminate thermal history.
Experimental and Numerical Investigation on Seismic Performance of RC Exterior Beam-Column Joints with Slabs
Authors: Wang Zhimeng , Huang Jiao , Chang Zhaoqun , Lu Yongjian
Published: September 2022

The effect of a cast-in-place slab on the beam-column joint at beam ends in reinforced concrete (RC) structures under earthquake attacks has not been fully understood, and therefore, it is not manifestly addressed to some of the design criteria or specifications. Consequently, the contribution of slab to the seismic resistance of structures is often ignored or just included in an approximate manner. In this study, the experiment of two 1/2-scaled exterior beam-column joints without slabs and three 1/2-scaled joints with slabs under the combination of quasi-static repeated cyclic loading and constant axial force was carried out to investigate the effect of the cast-in-place slab on the seismic performance of exterior beam-column joints. The results show that for specimens EBCJ1 and EBCJ2 without slab, the decline was approximately 5%, while for specimens EBCSJ1 and EBCSJ3, the decline in the load is obvious and approximately more than 10%. For specimen EBCSJ2, which exhibited a slightly different behavior in the hysteresis curves, the maximum carrying capacity reached at the displacement of 70 mm during the first cycle. The cast-in-place slab has different effects on the failure mechanism and load transfer mechanism of the exterior beam-column joint, which depends on the column-beam moment strength ratio in the loading protocol. The slab has a positive effect on the energy dissipation capacity of the joint but has a negative effect on the load carrying capacity. In addition, finite element (FE) analysis of the tested specimens was conducted. The FE numerical models were established based on the construction information and loading conditions from the experiment and then validated by comparing them with the experimental observation.
Optimization of Oil Yield from the Macro Algae Spirogyra by Solvent Extraction Process Using RSM and ANN
Authors: Aravind S. , Barik Debabrata , Ashok Nagaraj
Published: September 2022

The present work was done to optimize the process parameters of the oil extraction from the algae species spirogyra by using n-hexane as the solvent using the Soxhlet apparatus. The response surface methodology (RSM) and artificial neural network (ANN) were employed to optimize the particle size of the algae powder, dryness level of the algae powder, solid to solvent ratio, reaction time, and extraction temperature of the oil extraction process. Also, the physiochemical properties of the extracted oil were investigated. The comparative evaluation was done between the RSM and ANN models to select the more precise and accurate model. The coefficient of determination,

R

2

of 98.92%, and the mean absolute percentage deviation (MAPD) of 0.492% for ANN revealed that the current model created with a network topology of 3 : 11 : 1 with tansig (hyperbolic tangent sigmoid) transfer function in the input layer and purelin (pure linear) transfer function in the output layer trained with trainlm (Levenberg–Marquardt) algorithm found to provide the optimal solution with better accuracy in prediction of the output. The physicochemical properties investigated, such as heating value, flashpoint, density, viscosity, iodine number, acid value, saponification value, and cetane index, showed that the extracted oil from the algae spirogyra species can be used as an alternative fuel.
Cultural Value and Strategy of Ethnic Music Based on Distribution Estimation Algorithm
Authors: Shi Junyan , Ning Qinliang
Published: September 2022

The current social construction process is gradually accelerating, and people’s growing spiritual and cultural needs are eager to be satisfied. Spiritual culture is conceived from the material production process of human beings. It is a unique ideology of human beings that is different from other animals. National music culture is a branch of spiritual culture. It occupies an indispensable position in China, and its development is closely related to the inheritance of national culture. At present, the cultural value of ethnic music has not been fully excavated. The reason is that the research methods used are relatively backward, resulting in insufficient optimization of the analysis method. Therefore, this paper applied the distribution estimation algorithm and the information index method to the analysis of the cultural value and strategy of ethnic music. After simulating 120 samples, this paper obtained four results: convergence rate results, average optimal value results, sorting effect results, and final optimization degree results. The experimental results showed that the research method after applying the distribution estimation algorithm can improve the optimization degree of the value and strategy analysis of ethnic music culture by 5.81%, which is conducive to the better value of ethnic music culture in social spiritual and cultural construction.
An Improved Directed Crossover Genetic Algorithm Based on Multilayer Mutation
Authors: Xie Feng , Sun Quansheng , Zhao Yinfeng , Du Haibo
Published: September 2022

In order to solve the shortcomings of traditional genetic algorithms in image matching in terms of computational speed and matching accuracy, this paper proposes a directed crossover genetic matching algorithm (DCGA) based on multilayer variation. The algorithm differs from the traditional genetic algorithm (GA) in which the crossover strategy is improved and a multilayer adaptive variation operator is introduced. The crossover operation selects a certain proportion of spherical individuals from each generation as the evolutionary target, and the rest of the individuals evolve towards it in each dimension; the variation operation stratifies the population and adopts different adaptive variation methods for different layers. Avoiding the shortcomings of traditional genetic algorithms that tend to fall into local extremes, thus alleviating premature convergence, improves the search performance of the algorithm. The algorithm proposed in this paper is compared with the commonly used genetic algorithm by testing the effect of the function and tested practically in template matching. The experimental results show that the improved genetic algorithm has better convergence speed and search accuracy.
Tumor Necrosis Factor-Alpha Disrupts Cx43-Mediated Corneal Endothelial Gap Junction Intercellular Communication
Authors: Meng Jufeng , Xu Ke , Qin Yinyin , Liu Ya , Xu Lin , Qiao Shigang , An Jianzhong , Liu Jianjun , Zhang Zhenhao
Published: September 2022

Connexin43 (Cx43)-mediated gap junctions are vital in maintaining corneal endothelium homeostasis. Tumor necrosis factor-alpha (TNF-α) is among the most important inflammatory factors which cause corneal endothelial dysfunction in various eye diseases. However, the effect of TNF-α on Cx43-mediated gap junctions of the corneal endothelium remains undefined. In the current research, we determined the effect of TNF-α on gap junction intercellular communication (GJIC) in rabbit corneal endothelium. To evaluate alterations of GJIC, if any, we treated ex vivo cultured rabbit corneal endothelium with different concentrations of TNF-α (2-20 ng/ml). The localization of Cx43 was analyzed by immunostaining, while RT-qPCR and western blot were used to profile the expression of Cx43 and zonula occludens-1 (ZO-1). The association between ZO-1 and Cx43 was evaluated using immunoprecipitation and double staining. GJIC activity was determined by the scrap loading and dye transfer assay (SLDT). Our data demonstrated that a high concentration of TNF-α (10 ng/ml and 20 ng/ml) disrupts the Cx43 mediated gap junction distribution in rabbit corneal endothelium and suppresses the expression of Cx43 protein. Furthermore, rabbit corneal endothelial GJIC was inhibited due to the decreased association between the ZO-1 and Cx43 proteins. Current results demonstrate that TNF-α inhibits corneal endothelial GJIC via decreasing the association between ZO-1 and Cx43, disrupting the distribution of Cx43, and downregulating the expression of Cx43 protein. This study offers a new theoretical foundation for diagnosing and treating corneal endothelial cell decompensation induced by elevated TNF-α in various eye diseases.
Comparative Study of Conventional Inverted ILM Flap Covering and ILM Flap Filling Technique in Idiopathic Macular Hole Treatment: A Meta-Analysis and Systematic Review
Authors: Tao Mengying , Wang Guoqing , Gou Yueqin , Zhang Ming
Published: September 2022

Objective. This meta-analysis was performed to evaluate the anatomical efficacy and functional improvement of the conventional inverted internal limiting membrane (ILM), flap covering technique, and ILM flap filling technique for patients with idiopathic macular hole (MH). Methods. Literature from Pubmed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were comprehensively retrieved. The primary outcomes included the MH closure rate and postoperative best-corrected visual acuity (BCVA). The secondary outcomes were the proportion of external limiting membrane (ELM) and ellipsoid zone (EZ) defect recovery. Pooled odds ratios (ORs), weighted mean differences (WMDs), and 95% confidence intervals (CIs) were calculated using STATA 17.0 software. Results. 7 studies that contained 139 eyes in the inverted ILM flap covering group and 121 eyes in the ILM flap filling group were selected. Pooled data suggested that the surgical treatment resulted in an overall MH closure rate of up to 97.12% (135/139 eyes) in the inverted ILM flap covering group and 99.17% (120/121 eyes) in the filling group, with no significant difference between the 2 groups (OR = 1.98, 95% CI: 0.55 to 7.09, and

P
=
0.29

). Similarly, the 2 techniques demonstrated equal effectiveness on the anatomical closure in MH with the average diameter smaller than 650 μm (OR = 2.17, 95% CI: 0.48 to 9.77, and

P
=
0.31

) and larger than 650 μm (OR = 1.58, 95% CI: 0.14 to 17.37, and

P
=
0.71

). However, compared with the filling technique, the inverted ILM flap covering technique was superior in postoperative BCVA (WMD = 0.11, 95% CI: 0.04 to 0.18, and

P
=
0.0017

) and presented a significantly higher proportion of reconstitution of ELM (OR = 0.02, 95% CI: 0.00 to 0.08, and

P
<
0.0001

) and EZ (OR = 0.11, 95% CI: 0.04 to 0.32, and

P
=
0.0001

). Conclusion. The inverted ILM flap covering technique was associated with the superior reconstitution of outer layers of the retina, including ELM and EZ, and more improvement in postoperative BCVA than the ILM flap filling technique.