bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimating bacterial breakthrough behaviors based on bacterial retention profiles in porous media
Authors: Chen Fengxian , Yang Liqiong , Chen Xijuan , Zhuang Jie
Published: April 2024

Traditional methods for assessing bacterial transport in soil or permeable sand aquifers, such as flow‐through experiments, breakthrough curve (BTC), and retention profile (RP) analysis, face challenges due to their complexity and the labor‐intensive nature of in situ implementations. This study seeks to address the question: How can the transport behavior of bacteria in soil be predicted in a simpler and more cost‐effective manner using RPs? We introduce an RP method designed to overcome these challenges by utilizing soil sampling at various depths to model bacterial breakthrough behaviors with greater efficiency. By employing the one‐site attachment/detachment model within the Hydrus 1D framework, our research compares the RP method (three RPs) against the conventional approach (BTC + RP), showcasing its efficacy through column experiments with bioluminescent Escherichia coli in humic acid‐coated sand. The results indicate that the accuracy of RP method aligns closely with traditional methods in predicting bacterial transport. This technique allows for the use of solid samples collected from a limited number of depths to predict breakthrough behaviors accurately, making it suitable for evaluating bacterial transport in settings such as farmlands, contaminated lands, riverbanks, and soil aquifer treatment systems. Our findings underscore the RP method's role in streamlining experimental procedures and its potential application in environmental science and agronomy.
Anti‐Coronavirus Activity of Certain Herbacetin Derivatives, A Theoretical Study
Authors: Rafiee Marjan A.
Published: April 2024

Flavonoids are natural products commonly found in the human diet with anti‐viral activity. The electrochemical activity of flavonoids is effective in their inhibitory properties. Herbacetin is an anti‐coronavirus drug from the flavonoid family. To understand structure‐electrochemical activity relations, ab initio calculations on some selected herbacetin derivatives were carried out using Gaussian 09 in B3LYP/6‐311G*. The effect of the position and type of the various substituents in the ring A of the flavone backbone are considered. The oxygen charge density of the hydroxyl group on C8 (O8) in the considered herbacetins was compared using nuclear quadrupole coupling constants (NQCC) calculations. Results showed that the presence of the amino group in the ortho position of O8 has the most significant effect on increasing the charge density of the O8 atom (O8‐NQCC=9.23 MHz). Based on the proposed mechanism of these drugs, ortho‐amino herbacetin is expected to show a significant anti‐coronavirus effect. Comparison of calculated O8‐NQCCs of tangeretin and nobiletin with herbacetin shows that with the replacement of OH with OCH3, the charge density of oxygen atoms decreases (about 2 MHz). Therefore tangeretin and nobiletin have a lower drug effect than herbacetin. Natural bond orbital (NBO) results are in agreement with calculated NQCCs.
Highly Versatile, Non‐noble Metal‐Based Catalytic Process for the Production of Green Aromatics and High‐Octane Fuel from Bio‐Derived Hydrocarbon Mix
Authors: Kumar Mahesh , Prakash Tathod Anup , Singh Vijendra , Arumugam Selvamani , Viswanadham Nagabhatla
Published: April 2024

The present work deals with the value‐addition to bio‐derived hydrocarbon mix obtained as a side product in biorefinery for petrochemicals and fuel applications. One aspect of this study focused on developing a highly versatile, non‐noble metal‐based catalytic process to facilitate the production of green aromatics and high‐octane fuel from a renewable bio‐derived hydrocarbon mix. Considering the availability of various conventional/unconventional feedstocks viz. industrial petroleum naphtha and crude‐derived hydrocarbon mix, the catalyst development is also expanded for effective conversion of such feedstocks to produce aromatics. For this, a detailed understanding of the catalyst property‐activity relationship has been established with the help of characterization techniques like FTIR, XRD, NH3‐TPD, Pyridine‐IR, N2 adsorption‐desorption, HR‐TEM, XPS, TGA, etc. The studies revealed promising catalytic activity of 5Zn‐2Ga‐0.5Ba/H‐ZSM‐5 to exhibit very high aromatic selectivity (up to 80 %) and high‐octane fuel production (>100 RON) from all the feedstocks possessing different hydrocarbon composition. The catalyst showed good repeatability and recyclability at the tested reaction conditions.
Adsorption of Coomassie Brilliant Blue on a Novel Eco‐Friendly Nanogel from Simulated Water: Equilibrium, Kinetic, and Thermodynamic Studies
Authors: Khan Suhail Ayoub , Manchanda Ankita , Khan Tabrez Alam
Published: April 2024

Herein a novel gum acacia‐alginate nanogel (GAA) was synthesized via ultrasound‐assisted crosslinking by DPPH and applied for the removal of coomassie brilliant blue (CBB) dye. The fabrication of GAA and its interaction with CBB was specified via FTIR, XRD, SEM, and TEM techniques. The process parameters at which maximum adsorption efficiency, qe (80.12 mg/g), and % efficiency >94 % were achieved include dosage (0.8 g/L), time (80 min), initial dye concentration (20 mg/L), and pH (6). Ultrasound‐assisted uptake was greater than stirring‐assisted due to acoustic cavitation′s hydrodynamic and thermal processes. Pseudo‐second‐order model described the adsorption kinetics and the diffusion mechanism suggested that the rate‐determining step was controlled by both the intraparticle diffusion and the liquid film models. Isotherms showed an excellent fit to the Freundlich model based on higher R2 (0.998) and lower standard error of estimate values (SEE=0.367). The −ΔG° values (−8.152, −8.292, −8.433, −8.586 kJ/mol) indicated that the adsorption process was feasible and spontaneous. The removal of CBB ensued via hydrogen bonding, electrostatic, π‐π, and n‐π interactions. The maximum adsorption capacity of 182.096 mg/g, eco‐friendly characteristics along with regeneration competence depicted that GAA could be effective for scavenging CBB from wastewater.
Photocatalytic Degradation of Maxilon Dye Pollutants using Nano‐Architecture Functional Materials: A Review
Authors: Emmanuel Stephen Sunday , Adesibikan Ademidun Adeola , Olawoyin Christopher Olusola , Idris Mustapha Omenesa
Published: April 2024

The most essential task in the twenty‐first century is to fight the alarming growing pollution in the aquatic body in which effluent of one of the most colouring dye categories called maxilon dye is a major contributor. This review thus specifically focuses on the use of nanoparticles (NPs) for photocatalytic degradation of maxilon dye contaminants in water bodies. The work empirically presented the performance evaluation of NPs in degrading maxilon dyes under light irradiation alongside the underlying operational photocatalytic degradation mechanism. The stability of NPs was also critically analyzed by looking at the regenerability and reusability of expended NPs. From the study, it was discovered that ⋅OH and O2⋅ played a vital role in the genesis of the oxidizing capacity of NPs for the photocatalytic breakdown of maxilon dye. Moreover, it was found that the degradation performance of most NPs is greater than 80 % and the shortest degradation period is < 1 hour with pseudo‐first‐order (PFO) being the most common kinetic best‐fit to describe the adsorption process that occurred shortly before and during the degradation operation. At the end, knowledge gaps were identified in the area of regenerability, the lifecycle analyses of nano‐photocatalyst fabrication and utilization, cost analysis for industrial scale‐up, maxilon dye ecotoxicological study, and degradation pathways. The findings of this study can open up insightful innovation for readers and industries that are interested in pursuing zero water insecurity.
Temperature/GSH Dual Responsive Fluorinated Mesoporous Silica‐Coated Au NRs for Serum‐Resistant Gene Delivery**
Authors: Sun Weitao , Fu Chunhua , Zhang Zhongyu , Sun Wan
Published: April 2024

Mesoporous silica nanoparticles (MSN) are emerging as one of the most appealing candidates for gene carriers. Nevertheless, one major obstacle for their clinical application is the lack of efficient controlled release and gene delivery. In this study, a mesoporous silica‐modified gold nanorods (Au NRs) controlled release platform was synthesized. Then a thermosensitive copolymer was grafted to the surface of release platform, to impart the switching response of carrier under the photothermal of Au NRs. Fluorination were modified on the surface of MSN through a disulfide bond to achieve glutathione (GSH) response release and improve serum‐resistant ability. This gene carrier, with notable DNA condensation ability and negligible cytotoxicity, could be easily internalized into cells, enhanced green fluorescent protein expression in the presence of serum under laser irradiation. This work inspired us to solve the problem of traditional controllable sustained release and realize the performance of intracellular switch response to gene sustained release.
Recent Progress in Electrochemical Conversion from Biomass Derivatives into High‐Value‐Added Chemicals
Authors: Sun Yao , Miao Jiaming , Fan Xinyi , Zhang Kan , Zhang Tierui
Published: April 2024

Selective and efficient electrochemical conversion of cheap and abundant biomass derivatives into high‐value‐added products can provide a way to store large‐scale renewable intermittent energy such as wind energy, solar energy, etc. Although a large amount of research is devoted to developing highly efficient catalysts or disclosing the reaction processes, there are always challenges of conversion rate and selectivity, and the relevant comprehensive and in‐depth discussion is relatively scarce. This review introduces the basic principles and reaction processes from the charge transfer pathway of biomass electrochemical conversion. Then, for the design of the anode, the representative work is summarized and discussed in detail from the point of view of material adjustment, theoretical calculations, and in situ characterizations. Finally, insights for further optimization of the reaction systems are put forward. It is believed that this review provides guidance for the selection, design, and application of materials for high‐value‐added organic electrochemical synthesis.
Prospect of Controlled Autoxidation to Produce High‐Value Products from the Low‐Value Petroleum Fractions
Authors: Siddiquee Muhammad N.
Published: April 2024

Substantial amounts of low‐value light petroleum fractions and low‐value heavy petroleum fractions, such as light naphtha, HVGO, and vacuum residue, are generated during the upgrading and refining of conventional and unconventional petroleum resources. The oil industry emphasizes economic diversification, aiming to produce high‐value products from these low petroleum fractions through cost‐effective and sustainable methods. Controlled autoxidation (oxidation with air) has the potential to produce industrially important oxygenates, including alcohols, and ketones, from the low‐value light petroleum fractions. The produced alcohols can also be converted to olefin through catalytic dehydration. Following controlled autoxidation, the low‐value heavy petroleum fractions can be utilized to produce value‐added products, including carbon fiber precursors. It would reduce the production cost of a highly demandable product, carbon fiber. This review highlights the prospect of developing an alternative, sustainable, and economic method to produce value‐added products from the low‐value petroleum fractions following a controlled autoxidation approach.
Gauged permutation invariant matrix quantum mechanics: path integrals
Authors: O’Connor Denjoe , Ramgoolam Sanjaye
Published: April 2024

Abstract

We give a path integral construction of the quantum mechanical partition function for gauged finite groups. Our construction gives the quantization of a system ofd,N × Nmatrices invariant under the adjoint action of the symmetric groupSN. The approach is general to any discrete group. For a system of harmonic oscillators, i.e. for the non-interacting case, the partition function is given by the Molien-Weyl formula times the zero-point energy contribution. We further generalise the result to a system of non-square and complex matrices transforming under arbitrary representations of the gauge group.
TLR5 agonist in combination with anti-PD-1 treatment enhances anti-tumor effect through M1/M2 macrophage polarization shift and CD8+ T cell priming
Authors: Lee Junseok , Im Keon-Il , Gil Sojin , Na Hyemin , Min Gi-June , Kim Nayoun , Cho Seok-Goo
Published: April 2024

Immune checkpoint inhibitors have revolutionized anti-tumor therapy, notably improving treatment responses in various tumors. However, many patients remain non-responsive and do not experience benefits. Given that Toll-like receptors (TLRs) can counteract tumor immune tolerance by stimulating both innate and adaptive immune responses, TLR agonists are being explored as potential immune adjuvants for cancer treatment. In this study, we assessed the potential of enhancing the efficacy of immune checkpoint inhibitors by activating innate immunity with a TLR5 agonist. In a mouse tumor model, combination therapy with TLR5 agonist and anti-PD-1 significantly inhibited tumor growth. The TLR5 agonist shifted the balance from M2-like to M1-like macrophages and upregulated the expression of co-stimulatory molecules in macrophages. Furthermore, TLR5 agonist promoted the activation and tumor infiltration of CD8+ T cells. As a result, the TLR5 agonist augmented the anti-tumor efficacy of anti-PD-1, suggesting its potential in modulating the tumor microenvironment to enhance the anti-tumor response. Our findings point toward the possibility of optimizing immune checkpoint inhibitor therapy using TLR5 agonists.
Antioxidant supplementation may effect DNA methylation patterns, apoptosis, and ROS levels in developing mouse embryos
Authors: Uysal Fatma , Sukur Gozde , Bozdemir Nazlican , Cinar Ozgur
Published: April 2024

This study was designed to address the question: does antioxidant-containing embryo culture media affect DNA methyltransferases, global DNA methylation, inner cell mass/trophoblast differentiation, intracellular reactive oxygen species (ROS) levels, and apoptosis? Mouse zygotes were cultured in embryo culture media containing MitoQ, N-acetyl-l-cysteine (NAC), acetyl-l-carnitine (ALC), α-lipoic acid (ALA), or the mixture of NAC + ALC + ALA (AO) until the blastocyst stage, whereas in vivo-developed blastocysts were used as control. Protein expression levels of Dnmt1, 3a, 3b, and 3l enzymes were analyzed by immunofluorescence and western blot, while global DNA methylation, apoptosis, and ROS levels were evaluated by immunofluorescence. NAC, ALC, and MitoQ significantly increased the levels of all Dnmts and global methylation. ALA significantly induced all Dnmts, whereas global methylation did not show any difference. NAC and mixture AO applications significantly induced Nanog levels, ALA and MitoQ increased Cdx2 levels, while the other groups were similar. ALA and MitoQ decreased while ALC increased the levels of intracellular ROS. This study illustrates that antioxidants, operating through distinct pathways, have varying impacts on DNA methylation levels and cell differentiation in mouse embryos. Further investigations are warranted to assess the implications of these alterations on the subsequent offspring.
Pancreatic head resection for carcinoma of the ampulla vateri – better long-term prognosis, but more postoperative complications
Authors: Kuesters Simon , Sundheimer Johanna , Wittel Uwe A. , Chikhladze Sophia , Fichtner-Feigl Stefan , Biesel Esther A.
Published: April 2024

Background

Pancreatoduodenectomies are complex surgical procedures with a considerable morbidity and mortality even in high-volume centers. However, postoperative morbidity and long-term oncological outcome are not only affected by the surgical procedure itself, but also by the underlying disease. The aim of our study is an analysis of pancreatoduodenectomies for patients with pancreatic ductal adenocarcinoma (PDAC) and ampullary carcinoma (CAMP) concerning postoperative complications and long-term outcome in a tertiary hospital in Germany.

Methods

The perioperative and oncological outcome of 109 pancreatic head resections performed for carcinoma of the ampulla vateri was compared to the outcome of 518 pancreatic head resections for pancreatic ductal adenocarcinoma over a 20 year-period from January 2002 until December 2021. All operative procedures were performed at the University Hospital Freiburg, Germany. Patient data was analyzed retrospectively, using a prospectively maintained SPSS database. Propensity score matching was performed to adjust for differences in surgical and reconstruction technique. Primary outcome of our study was long-term overall survival, secondary outcomes were postoperative complications and 30-day postoperative mortality. Postoperative complications like pancreatic fistula (POPF), postpancreatectomy hemorrhage (PPH) and delayed gastric emptying (DGE) were graded following current international definitions. Survival was estimated using Kaplan Meier curves and log-rank tests. A p-value < 0.05 was considered statistically significant.

Results

Operation time was significantly longer in PDAC patients (432 vs. 391 min, p < 0.001). The rate of portal vein resections was significantly higher in PDAC patients (p < 0.001). In CAMP patients, a pancreatogastrostomy as reconstruction technique was performed more frequently compared to PDAC patients (48.6% vs. 29.9%, p < 0.001) and there was a trend towards more laparoscopic surgeries in CAMP patients (p = 0.051). After propensity score matching, we found no difference in DGE B/C and PPH B/C (p = 0.389; p = 0.517), but a significantly higher rate of clinically relevant pancreatic fistula (CR-POPF) in patients with pancreatoduodenectomies due to ampullary carcinoma (30.7% vs. 16.8%, p < 0.001). Long-term survival was significantly better in CAMP patients (42 vs. 24 months, p = 0.003).

Conclusion

Patients with pancreatoduodenectomies due to ampullary carcinomas showed a better long-term oncological survival, by reason of the better prognosis of this tumor entity. However, these patients often needed a more elaborated postoperative treatment due to the higher rate of clinically relevant pancreatic fistula in this group.
Electricity generation and real oily wastewater treatment by Pseudomonas citronellolis 620C in a microbial fuel cell: pyocyanin production as electron shuttle
Authors: Varnava Constantina K. , Persianis Panagiotis , Ieropoulos Ioannis , Tsipa Argyro
Published: April 2024

In the present study, the potential of Pseudomonas citronellolis 620C strain was evaluated, for the first time, to generate electricity in a standard, double chamber microbial fuel cell (MFC), with oily wastewater (OW) being the fuel at 43.625 mg/L initial chemical oxygen demand (COD). Both electrochemical and physicochemical results suggested that this P. citronellolis strain utilized efficiently the OW substrate and generated electricity in the MFC setup reaching 0.05 mW/m2 maximum power. COD removal was remarkable reaching 83.6 ± 0.1%, while qualitative and quantitative gas chromatography/mass spectrometry (GC/MS) analysis of the OW total petroleum and polycyclic aromatic hydrocarbons, and fatty acids revealed high degradation capacity. It was also determined that P. citronellolis 620C produced pyocyanin as electron shuttle in the anodic MFC chamber. To the authors’ best knowledge, this is the first study showing (phenazine-based) pyocyanin production from a species other than P. aeruginosa and, also, the first time that P. citronellolis 620C has been shown to produce electricity in a MFC. The production of pyocyanin, in combination with the formation of biofilm in the MFC anode, as observed with scanning electron microscopy (SEM) analysis, makes this P. citronellolis strain an attractive and promising candidate for wider MFC applications.
Towards a tailored approach for patients with acute diverticulitis and abscess formation. The DivAbsc2023 multicentre case–control study
Authors: Podda Mauro , Ceresoli Marco , Di Martino Marcello , Ortenzi Monica , Pellino Gianluca , Pata Francesco , Ielpo Benedetto , Murzi Valentina , Balla Andrea , Lepiane Pasquale , Tamini Nicolo’ , De Carlo Giulia , Davolio Alessia , Di Saverio Salomone , Cardinali Luca , Botteri Emanuele , Vettoretto Nereo , Gelera Pier Paolo , De Simone Belinda , Grasso Antonella , Clementi Marco , Meloni Danilo , Poillucci Gaetano , Favi Francesco , Rizzo Roberta , Montori Giulia , Procida Giuseppa , Recchia Irene , Agresta Ferdinando , Virdis Francesco , Cioffi Stefano Piero Bernardo , Pellegrini Martina , Sartelli Massimo , Coccolini Federico , Catena Fausto , Pisanu Adolfo
Published: April 2024

Background

This multicentre case–control study aimed to identify risk factors associated with non-operative treatment failure for patients with CT scan Hinchey Ib-IIb and WSES Ib-IIa diverticular abscesses.

Methods

This study included a cohort of adult patients experiencing their first episode of CT-diagnosed diverticular abscess, all of whom underwent initial non-operative treatment comprising either antibiotics alone or in combination with percutaneous drainage. The cohort was stratified based on the outcome of non-operative treatment, specifically identifying those who required emergency surgical intervention as cases of treatment failure. Multivariable logistic regression analysis to identify independent risk factors associated with the failure of non-operative treatment was employed.

Results

Failure of conservative treatment occurred for 116 patients (27.04%). CT scan Hinchey classification IIb (aOR 2.54, 95%CI 1.61;4.01, P < 0.01), tobacco smoking (aOR 2.01, 95%CI 1.24;3.25, P < 0.01), and presence of air bubbles inside the abscess (aOR 1.59, 95%CI 1.00;2.52, P = 0.04) were independent predictors of failure. In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2.78, 95%CI − 0.66;3.70, P = 0.23).

Conclusions

Non-operative treatment is generally effective for diverticular abscesses. Tobacco smoking's role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. Further research into the efficacy of image-guided percutaneous drainage should involve randomized, multicentre studies focussing on homogeneous patient groups.

Graphical abstract
Lasers in the management of alopecia: a review of established therapies and advances in treatment
Authors: Jean-Pierre Philippe , Pulumati Anika , Kasheri Eli , Hirsch Melanie , Nouri Keyvan
Published: April 2024

Alopecia, also known as hair loss, is a highly prevalent condition affecting millions of men and women in the United States and worldwide, making it one of the most common complaints by patients presenting to a dermatologist. The symptomology on the presentation of alopecia can be highly variable, ranging from diffuse thinning of hair, discrete and localized patches completely absent of hair, or noticing significant shedding when brushing and showering. Although alopecia does not have a direct negative health impact on patients, it is nonetheless a debilitating disease as it can profoundly impact an individual’s self-image and psychosocial well-being. There are multiple treatment options available to patients with alopecia, and they are typically tailored to the patient’s needs and preferences. The most common of these is the Food and Drug Administration-approved drugs for alopecia, minoxidil, and finasteride. However, both of these are known to be partially efficacious for all patients, so clinicians often use different modalities in conjunction with them, in particular laser-based therapies. This review article will provide a comprehensive assessment of lasers and other light therapies that may be used to manage the two most common types of alopecia: androgenetic alopecia and alopecia areata.
Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
Authors: Kul Ayse Nilgun , Ozturk Kurt Bahar
Published: April 2024

Trace elements are essential micronutrients for the human body. Their roles are indispensable, as they are involved in a wide range of vital biological processes. In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females). In addition, trace element levels were analyzed in bone marrow samples from the patient group. Blood and bone marrow serum levels were quantified using inductively coupled plasma optical emission spectrometry. When the blood samples of the patient and control groups were compared: Zn (p = 0.011), Fe (p = 0.008), Mn (p = 0.046), Se (p < 0.001), As (p < 0.001), Ni (p < 0.001) and Cr (p < 0.001) levels were significantly higher in the patient group than in the control group. Higher Zn, Fe, Mn, Se, As, Ni and Cr levels in the NMM patients suggest that alterations of trace elements could be predisposing factor that initiates the malignant process. The relationship between malignancies and trace elements is crucial for the development of adjuvant therapy strategies and preventive medicine and as biomarkers for cancer diagnosis. Therefore, there is a need for studies examining the relationship between hematological malignancies and trace elements.
Signifiers for conveying and exploiting affordances: from human-computer interaction to multi-agent systems
Authors: Lemée Jérémy , Vachtsevanou Danai , Mayer Simon , Ciortea Andrei
Published: April 2024

The ecological psychologist James J. Gibson defined the notion of affordances to refer to what action possibilities environments offer to animals. In this paper, we show how (artificial) agents can discover and exploit affordances in a Multi-Agent System (MAS) environment to achieve their goals. To indicate to agents what affordances are present in their environment and whether it is likely that these may help the agents to achieve their objectives, the environment may expose signifiers while taking into account the current situation of the environment and of the agent. On this basis, we define a Signifier Exposure Mechanism that is used by the environment to compute which signifiers should be exposed to agents in order to permit agents to only perceive information about affordances that are likely to be relevant to them, and thereby increase their interaction efficiency. If this is successful, agents can interact with partially observable environments more efficiently because the signifiers indicate the affordances they can exploit towards given purposes. Signifiers thereby facilitate the exploration and the exploitation of MAS environments. Implementations of signifiers and of the Signifier Exposure Mechanism are presented within the context of a Hypermedia Multi-Agent System, and the utility of this approach is presented through the development of a scenario.
Pyrroloquinoline quinone protects against murine hepatitis virus strain 3-induced fulminant hepatitis by inhibiting the Keap1/Nrf2 signaling
Authors: Pu Zunguo , Ge Fei , Zhou Yaqing , Liu Aiming , Yang Chao
Published: April 2024

Fulminant hepatitis (FH) is a life-threatening clinical liver syndrome characterized by substantial hepatocyte necrosis and severe liver damage. FH is typically associated with severe oxidative stress, inflammation, and mitochondrial dysfunction. Pyrroloquinoline quinone (PQQ), a naturally occurring redox cofactor, functions as an essential nutrient and antioxidant and reportedly inhibits oxidative stress and exerts potent anti-inflammatory effects. In the present study, we aimed to evaluate the therapeutic efficacy of PQQ in murine hepatitis virus strain 3 (MHV-3)-induced FH and examined the underlying mechanism. An MHV-3-induced FH mouse model was established for in vivo examination. Liver sinusoidal endothelial cells (LSECs) were used for in vitro experiments. Herein, we observed that PQQ supplementation significantly attenuated MHV-3-induced hepatic injury by suppressing inflammatory responses and reducing oxidative stress. Mechanistically, PQQ supplementation ameliorated MHV-3-induced hepatic damage by down-regulating the Keap1/Nrf2 signaling pathway in vivo and in vitro. Furthermore, Nrf2 small interfering RNA targeting LSECs abrogated the PQQ-mediated protective effects against MHV-3-related liver injury. Our results deepen our understanding of the hepatoprotective function of PQQ against MHV-3-induced liver injury and provide evidence that alleviating oxidative stress might afford a novel therapeutic strategy for treating FH.
A novel asymptotically consistent approximation for integral evaporation from a spherical cap droplet
Authors: Wray Alexander W. , Moore Madeleine R.
Published: April 2024

The total evaporation rate due to a volatile capillarity-dominated droplet diffusively evaporating into the surrounding gas is a critically important quantity in industrial and engineering applications such as Q/OLED screen manufacturing. However, the analytical expression in terms of integrals in toroidal coordinates can be unwieldy in applications, as well as expensive to compute. Therefore, simple yet highly accurate approximate solutions are frequently used in practical settings. Herein we present a new approximate form that is both accurate and fast to compute, but also retains the correct asymptotic behaviour in the key physical regimes, namely hydrophilic and superhydrophobic substrates, and a hemispherical droplet. We illustrate this by comparison to several previous approximations and, in particular, illustrate its use in calculating droplet lifetimes, as well as approximating the local evaporative flux.
A novel time-dependent analytical model for optimizing efficiency and valve timing in Ericsson engines
Authors: Tzouganakis Panteleimon , Gakos Vasilios , Kalligeros Christos , Papalexis Christos , Spitas Vasilios
Published: April 2024

In this work, a novel analytical time-sensitive model for Ericsson engines was developed taking into account the heat transfer phenomena between the working gas and the cylinder walls in the compressor and the expander. For the calculation of the mass flow entering/exiting each cylinder, another dedicated flow model was developed to account for the pressure drop at the valves. From the energy equilibrium taking into consideration the time-dependent thermal response of the cylinder walls and the enthalpy entering/exiting each cylinder through the valves, an analytical solution of the working gas pressure and temperature can be obtained for every time step and consequently, the thermal efficiency of the engine can be calculated. A case study was performed where the thermal efficiency of an Ericsson engine was calculated for different rotational speeds and heat exchanger gas temperatures. It was observed that with higher temperatures thermal efficiency maintained a more stable behaviour with a weak dependence on rotational speed. The thermal efficiency of the engine in the performed case studies was found in the range of 10% to 14%. The valve timing of the Ericsson engine was optimized in order to achieve the highest thermal efficiency possible. The thermal efficiency of the engine could be increased up to 26% as a percentage after a thorough optimization of the valve timing. Finally, backflow phenomena accounting for thermal efficiency drop were studied. The developed model can also be applied to other types of external combustion engines such as Stirling engines.
Making Science Relevant: Comparing Two Science Advisory Organizations Beyond the Linear Knowledge Model
Authors: Sundqvist Göran , Linke Sebastian
Published: April 2024

This article compares two science advisory organizations: the Intergovernmental Panel for Climate Change (IPCC) and the International Council for the Exploration of the Seas (ICES), with a special focus on how their respective policy systems absorb the knowledge delivered for use in decision processes. The science-policy processes of these two organizations differ in important respects; ICES delivers highly specified knowledge to a specified uptake mechanism, while the IPCC produces unspecified knowledge for an unspecified uptake mechanism. Since both environmental governance areas are criticized for lack of needed action, a comparison is of interest asking how this might relate to the organization of science advice. As theoretical resources for this explorative comparison we utilize two approaches from the field of science and technology studies: the co-production approach, which focuses on the entanglements of scientific and political processes, and the systems-theory-oriented multiple-worlds model, which assumes a clear difference in institutional logics between the scientific and the political field. Since the IPCC has been critically analysed by several studies utilizing resources from the two approaches, we contribute with new insights by bringing in ICES, which is a much less studied organization exposing a different science-policy structure. One important finding is that the two theoretical approaches focus on different aspects, exposing ‘links’ and ‘integration’, both of which we argue are important for analysing and assessing science advisory organizations. Moreover, these aspects can be advantageously integrated into a single theoretical framework.
Antimicrobial Activity Classification of Imidazolium Derivatives Predicted by Artificial Neural Networks
Authors: Lorenc Andżelika , Badura Anna , Karolak Maciej , Pałkowski Łukasz , Kubik Łukasz , Buciński Adam
Published: April 2024

Purpose

This study assesses the Multilayer Perceptron (MLP) neural network, complemented by other Machine Learning techniques (CART, PCA), in predicting the antimicrobial activity of 140 newly designed imidazolium chlorides against Klebsiella pneumoniae before synthesis. Emphasis is on leveraging molecular properties for predictive analysis.

Methods

Classification and regression decision trees (CART) identified the top 200 predictive molecular descriptors. Principal Component Analysis (PCA) reduced these descriptors to 5 components, retaining 99.57% of raw data information. Antimicrobial activity, categorized as high or low, was based on experimentally proven minimal inhibitory concentration (MIC), with a cut-point at MIC = 0.856 mol/L. A 12-fold cross-validation trained the MLP (architecture 5-12-2 with 5 Principal Components).

Results

The MLP exhibited commendable performance, achieving almost 90% correct classifications across learning, validation, and test sets, outperforming models without PCA dimension reduction. Key metrics, including accuracy (0.907), sensitivity (0.905), specificity (0.909), and precision (0.891), were notably high. These results highlight the MLP model's efficacy with PCA as a high-quality classifier for determining antimicrobial activity.

Conclusions

The study concludes that the MLP neural network, along with CART and PCA, is a robust tool for predicting the antimicrobial activity class of imidazolium chlorides against Klebsiella pneumoniae. CART and PCA, used in this study, allowed input variable reduction without significant information loss. High classification accuracy and associated metrics affirm the method’s potential utility in pre-synthesis assessments, offering valuable insights for antimicrobial compound design.
Spatial biases in processing mirror letters by literate subjects
Authors: Patro Katarzyna , Gross Antonia , Friedrich Claudia
Published: April 2024

Preschool children often confuse letters with their mirror images when they try to read and write. Mirror confusion seems to occur more often in line with the direction of script (e.g., left-to-right for the Latin alphabetic script), suggesting that the processing of letter orientation and text directionality may be interrelated in preliterate age. When children go to school, mirror mistakes in writing/reading letters disappear. Here we ask whether the processing of letter shapes and text direction are still related in readers at different proficiency levels. Literate subjects – school children from the 1st and 4th grades and adults – decided under time pressure whether a displayed letter was oriented correctly or incorrectly (mirrored). We observed that reaction times were faster when a letter was oriented rightward, i.e. in line with the cultural text direction (left-to-right), but we did not find any differences between the groups. We conclude that, even if mirror mistakes disappear during primary school years, letter shapes are still processed in a close relation to the left-to-right reading direction in the Latin script.
Exploring the writing attainment gap: profiling writing challenges and predictors for children with English as an additional language
Authors: Booton Sophie A. , Menon Prerna , Kyriacou Maria , Murphy Victoria A.
Published: April 2024

While there is some evidence of a gap in English writing achievement between children with English as an additional language (EAL) compared to their monolingual English-speaking (EL1) peers, the source of this gap remains unclear. This study examines whether writing presents a specific challenge for children with EAL beyond their oral language and reading skills, and whether the factors affecting writing skills differ between EAL and EL1 groups. In a longitudinal design, 100 children aged 9 to 10 years completed a fiction writing task and single-word spelling task twice over a school year. They also completed a non-fiction writing task, and measures of nonverbal intelligence, receptive vocabulary, expressive and receptive oral language, decoding, and reading comprehension. Children with EAL demonstrated lower general writing performance than monolinguals, commensurate with their other language and reading skills, but a relative strength in single-word spelling. Predictors were similar for children with EAL and monolinguals, with decoding skill predicting spelling and writing, and expressive oral language predicting writing. Effects of genre and specific writing sub-skills are also discussed, as well as implications for closing the writing attainment gap.
The Egyptian national HPC grid (EN-HPCG): open-source Slurm implementation from cluster to grid approach
Authors: Elshambakey Mohammed , Maiyza Aya I. , Kashkoush Mona S. , Fathy Ghada M. , Hassan Hanan A.
Published: April 2024

Recently, Egypt has recognized the pivotal role of High Performance Computing in advancing science and innovation. Additionally, Egypt realizes the importance of collaboration between different institutions and universities to consolidate their own computational and data resources into a unified platform to serve different disciplines (e.g., scientific, industrial, governmental). Otherwise, additional resources would be needed to be purchased with the associated cost, effort, and time difficulties (e.g., setup, administration, maintenance, etc.). Thus, this paper delves into the architecture and capabilities of the EN-HPCG grid using two different workload management systems: (i) Slurm (Open-Source) and (ii) PBS Pro (Licensed). This paper compares the performance of the grid between Slurm and PBS Pro in specific high-throughput computing (HTC) applications using the NAS Grid parallel benchmark (NGB) to determine which workload manager is more suitable for EN-HPCG. The evaluation includes grid-level performance metrics such as throughput, and the number of tasks completed as a function of time. Also, the presented methodology aims to assist potential partners in their decision-making process to join the EN-HPCG grid, with a focus on the site speed-up metric. Our results showed that, unless an open-source solution without cost and license problems is an obligation (in which case, Slurm is the viable solution), then it is not advisable to integrate a cluster with high-speed hardware with a cluster possessing outdated hardware when using the Slurm scheduler. In contrast, the PBS Pro scheduler takes into account online decision-making in a dynamic environment using a unified grid.
Exploring raw data transformations on inertial sensor data to model user expertise when learning psychomotor skills
Authors: Portaz Miguel , Corbi Alberto , Casas-Ortiz Alberto , Santos Olga C.
Published: April 2024

This paper introduces a novel approach for leveraging inertial data to discern expertise levels in motor skill execution, specifically distinguishing between experts and beginners. By implementing inertial data transformation and fusion techniques, we conduct a comprehensive analysis of motor behaviour. Our approach goes beyond conventional assessments, providing nuanced insights into the underlying patterns of movement. Additionally, we explore the potential for utilising this data-driven methodology to aid novice practitioners in enhancing their performance. The findings showcase the efficacy of this approach in accurately identifying proficiency levels and lay the groundwork for personalised interventions to support skill refinement and mastery. This research contributes to the field of motor skill assessment and intervention strategies, with broad implications for sports training, physical rehabilitation, and performance optimisation across various domains.
A case report of acute claudication due to vena cava thromboembolism in a dog naturally infected with Leishmania Infantum
Authors: Calvo-Sánchez Natalia , Gómez Álex , Pérez Estela , Borobia María , Luján Lluís , Fernández Antonio , Villanueva-Saz Sergio , Verde Maite , Marteles Diana
Published: April 2024

Canine leishmaniosis is a vector-borne disease caused byLeishmania infantum, and clinical manifestations of infection range from absent or severe to fatal and result from immune-mediated mechanisms. In dogs, the most common clinical signs of leishmaniosis include skin lesions and lymphadenomegaly. However, the presence of other nontypical signs has been described, and diagnosing these cases can be challenging. The aim of the present short communication was to describe the impact of the formation of circulating immunocomplexes due toL. infantumin a dog with leishmaniosis affected by a massive venous thrombus of the caudal vena cava and external iliac veins. On admission, the dog presented bilateral cutaneous vasculopathy of the thigh and renal disease due toL. infantuminfection. Two weeks after starting anti-Leishmaniatreatment based on meglumine antimoniate and allopurinol administration, the animal developed acute claudication of the hind limbs with the presence of a thrombus in the caudal vena cava and the external iliac veins and a high level of circulating immunocomplexes detected by enzyme-linked immunosorbent assay. Exacerbation of the humoral immune response, along with deposition of circulating immune complexes in the tissues and the concurrent presence of kidney and liver damage, might have contributed to an imbalance in haemostasis in this patient. Future studies should evaluate and analyse the pathological mechanisms contributing to thrombosis in dogs with leishmaniosis.
Decarbonizing energy: Evaluating fossil fuel displacement by renewables in OECD countries
Authors: Karlilar Pata Selin , Balcilar Mehmet
Published: April 2024

Energy transition to greener systems has been a focal point in climate policy agendas across countries as the negative environmental impacts of fossil fuel technologies have become more evident Displacing fossil fuels with clean energy alternatives in this regard is essential for meeting global climate objectives. In this context, the study analyzes the role of disaggregated renewable energy sources on fossil fuel displacement in 36 Organisation for Economic Cooperation and Development (OECD) countries in the period 2000–2020. The findings demonstrate a discernible trend in the displacement of fossil fuels by various forms of renewable energy sources. It is found that to effectively displace 1% of fossil fuels, it is necessary to achieve an average increase of 1.15% in renewable generation capacity. In addition, a one-to-one displacement of fossil fuels occurs with hydropower, demonstrating its higher level of competitiveness and effectiveness in displacing fossil fuels. Moreover, there is a partial displacement of fossil fuels by solar and wind power. These findings suggest that renewable energy sources are progressively advancing towards effectively displacing fossil fuels.
Attitudes of people diagnosed with cancer and cancer care providers towards use of nicotine vaping products in high-income countries: a scoping review
Authors: Otieno Lavender A. , Baiju Jeffin , Trigg Joshua
Published: April 2024

Purpose

To investigate the attitudes, beliefs and perceptions of people diagnosed with cancer and health practitioners on use of nicotine vaping products.

Methods

Scopus and OVID Medline were searched for papers published between 2013 and 2023. Two authors independently selected the studies and extracted data, with conflicts resolved through discussion. Nine studies were selected for further synthesis. Reporting follows the PRISMA Scoping Reviews checklist.

Results

E-cigarettes were commonly perceived as less harmful compared to conventional cigarettes and less detrimental to cancer treatment effectiveness among people with a current or previous cancer diagnosis. This population also cited smoking cessation, smoking in non-smoking areas and less risky alternative as the most common reasons for e-cigarette use. Nevertheless, low levels of clinician support on the effectiveness of e-cigarettes as a smoking cessation tool/alternative were identified.

Conclusion

Findings show differences in beliefs and attitudes of e-cigarettes between clinicians and people diagnosed with cancer. Additional research into the health impacts of e-cigarettes in people with a current or previous cancer diagnosis will allow for greater congruence between patients and clinicians and assist providers in recommending effective tools for smoking cessation within this population.

Implications for Cancer Survivors

This study provides an overview of the attitudes, beliefs and perceptions of e-cigarette use among people with a current or previous diagnosis of cancer and health practitioners. Given the increased prevalence of e-cigarette use within this population, these findings highlight a greater need for dialogue between patients and clinicians regarding the safety and efficacy of these devices.
Weyl Sets in a Non-degenerate Truncated Matricial Hausdorff Moment Problem
Authors: Heide Max , Fritzsche Bernd , Kirstein Bernd , Mädler Conrad
Published: April 2024

Given a point w in the upper half-plane $$\Pi _{\mathord {+}}$$

Π
+

, we describe the set of all possible values F(w) of transforms $$F(z)\,{:=}\,\int _{[\alpha ,\beta ]}(x-z)^{-1}\sigma (\textrm{d}x)$$

F

(
z
)

:
=

∫

[
α
,
β
]

(
x
-
z
)

-
1

σ

(
d
x
)

, $$z\in \Pi _{\mathord {+}}$$

z
∈

Π
+

, corresponding to solutions $$\sigma $$
σ
to a (non-degenerate) truncated matricial Hausdorff moment problem. This set turns out to be the intersection of two matrix balls the parameters of which are explicitly constructed from the given data.