bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of Groundwater in Iraq-Wasit Governorate Using Remote Sensing and GIS
Authors: Bahet Ali Sadeq , Malik Mutasim Ibrahim
Published: December 2021

The groundwater in Iraq has been studied for the need for it due to the shortage of surface water levels.The vegetation cover index, the soil moisture index, and the surface water index were used to detect the presence of groundwater in Wasit Governorate, Iraq. Those indicators that appear on the ground cover and indicate the presence of groundwater in the study area were compared with the coordinates of wells underground water. The results were identical with information obtained from the Ministry of Water Resources.
Comparison of tree distribution in the province of Baghdad and other random by using high-resolution satellite image
Authors: Al-Hassany G S , Abdul-Ameer Z N
Published: December 2021

In this paper two, sites (Satellite„ Images) of planting groups (green areas) gathered from two different region in locale of Baghdad province : the first region represent luxury area and the other represent poor random region will„ be considered to recognize between„ them. The first group is made up of the most important plans in the province of„ Baghdad, while the second is a random gathering. The employing data might be a high-„ resolution adherent image, and the extricated scenes of a high-„ resolution toady image will„ be evaluated to be„ able to distinguish between them specifically by obsequious photos. The outcomes will be obtained using the„ Geographic data framework (GIS„Version 9.2) application.
Potential of urban green spaces for supporting horticultural production: a national scale analysis
Authors: Walsh Lael E , Mead Bethan R , Hardman Charlotte A , Evans Daniel , Liu Lingxuan , Falagán Natalia , Kourmpetli Sofia , Davies Jess
Published: December 2021

As urban areas and land-use constraints grow, there is increasing interest in utilizing urban spaces for food production. Several studies have uncovered significant potential for urban growing to supplement production of fruit and vegetables, focusing on one or two cities as case studies, whilst others have assessed the global scale potential. Here, we provide a national-scale analysis of the horticultural production potential of urban green spaces, which is a relevant scale for agri-food and urban development policy making using Great Britain (GB) as a case study. Urban green spaces available for horticultural production across GB are identified and potential yields quantified based on three production options. The distribution of urban green spaces within 26 urban towns and cities across GB are then examined to understand the productive potential compared to their total extent and populations. Urban green spaces in GB, at their upper limit, have the capacity to support production that is 8× greater than current domestic production of fruit and vegetables. This amounts to 38% of current domestic production and imports combined, or >400% if exotic fruits and vegetables less suited to GB growing conditions are excluded. Most urban green spaces nationally are found to fall within a small number of categories, with private residential gardens and amenity spaces making up the majority of space. By examining towns and cities across GB in further detail, we find that the area of green space does not vary greatly between urban conurbations of different sizes, and all are found to have substantial potential to meet the dietary needs of the local urban population. This study highlights that national policies can be suitably developed to support urban agriculture and that making use of urban green spaces for food production could help to enhance the resilience of the national-scale food system to shocks in import pathways, or disruptions to domestic production and distribution.
Mechanistic understanding of the sensing process by analyzing response curves of TiO2 based humidity sensors
Authors: Rakesh Balaji , Sharma Nipun , Nagar Rupali , Dhongade Vipul , Daware Krishna , Gosavi Suresh
Published: December 2021

Sensors function by interacting with an appropriate stimulus, undergo a change in property, which is then diagnosed by making some measurements. For any sensor, the type of interaction between analyte and sensor surface determines its overall performance. This article explores the philosophy in which primary measurements like response curves can hold information on the “type” of interaction occurring between analyte and sensing material. As case study, titanium oxide (TiO2) pellet sensors fabricated by sol-gel growth of TiO2 nanoparticles (as-grown and annealed) are investigated for humidity sensing at room temperature. The sensors display a very fast response in the 0%–30% relative humidity (%RH) range and return to their initial state without applying any external heat treatment. The response curves are analysed in view of adsorption processes guided by Langmuir isotherms. Correlation between sensor microstructure, adsorption processes and response curve is used to build the mechanistic understanding of the sensing process. The results bring out a unique correlation between sensor microstructure, interaction of analyte with sensing material and profile of response curves. Further, the synthesised sensors exhibit a linear response in the 0%–30% RH range making them suitable for low humidity environments like food packaging industry.
Surface and dynamical properties of GeI2
Authors: Dhingra Archit , Lipatov Alexey , Lu Haidong , Chagoya Katerina , Dalton Joseph , Gruverman Alexei , Sinitskii Alexander , Blair Richard G , Dowben Peter A
Published: December 2021

GeI2 is an interesting two-dimensional wide-band gap semiconductor because of diminished edge scattering due to an absence of dangling bonds. Angle-resolved x-ray photoemission spectroscopy indicates a germanium rich surface, and a surface to bulk core-level shift of 1.8 eV in binding energy, between the surface and bulk components of the Ge 2p3/2 core-level, making clear that the surface is different from the bulk. Temperature dependent studies indicate an effective Debye temperature (

θ
D

) of 186 ± 18 K for the germanium x-ray photoemission spectroscopy feature associated with the surface. These measurements also suggest an unusually high effective Debye temperature for iodine (587 ± 31 K), implying that iodine is present in the bulk of the material, and not the surface. From optical absorbance, GeI2 is seen to have an indirect (direct) optical band gap of 2.60 (2.8) ± 0.02 (0.1) eV, consistent with the expectations. Temperature dependent magnetometry indicates that GeI2 is moment paramagnetic at low temperatures (close to 4 K) and shows a diminishing saturation moment at high temperatures (close to 300 K and above).
Assessment of land use change in the Thuma forest reserve region of Malawi, Africa
Authors: Phiri Mihla , Nyirenda Harrington
Published: December 2021

A study was conducted in Thuma area in central Malawi to quantify contemporary land cover and to explore the degree of land use change in the Thuma forest reserve area of Malawi by analysing and comparing satellite-derived land cover maps from 1997, 2007 and 2017. The study was carried out using Remote Sensing and Geographic Information System (GIS), focusing on analysis of Landsat 5 ETM and Landsat 8 ORI/TIRS satellite images. The classification was conducted for the following distinct classes; closed forest, open forest, shrubland, savanna grassland, agriculture fields, and water. The analysis revealed that closed forest diminished from 19% in 1997 to 10% in 2007 to 6% in 2017. Open forest reduced from 30% to 21% from 1997 to 2007 but increased to 22% in 2017. Agriculture area almost doubled from 37% in 1997 to 64% in 2017. The actual area from 1997 to 2017, shows that closed forest has reduced from 7,000 ha to 3,000 ha while open forest from 12,900 ha to 7800 ha. Savanna grassland has doubled from 5,900 ha to 13,000 ha. However, future studies should use modern satellites such as Sentinel and Landsat 9 for improved quantification of changes. The findings show that even the protected forest reserve (previously dominated by closed forest) is not fully protected from deforestation by local communities. Government and other stakeholders should devise measures to meet the needs of the surrounding communities and the ecological/biophysical needs of the reserves. Based on this study, issues of re-demarcation of the forest reserve and the accessed area should also be explored. This study serves as a reference for the management of Thuma Forest Reserve as a refuge for natural tree species, rivers that harbour endemic fish species (Opsaridium microlepisandOpsaridium microcephalis) and the sustainable management of endangered elephants in the reserve.
Use of Linked Databases for Improved Confounding Control: Considerations for Potential Selection Bias
Authors: Sun Jenny W , Wang Rui , Li Dongdong , Toh Sengwee
Published: December 2021

Pharmacoepidemiologic studies are increasingly conducted within linked databases, often to obtain richer confounder data. However, the potential for selection bias is frequently overlooked when linked data is available only for a subset of patients. We highlight the importance of accounting for potential selection bias by evaluating the association between antipsychotics and type 2 diabetes in youths within a claims database linked to a smaller laboratory database. We used inverse probability of treatment weights (IPTW) to control for confounding. In analyses restricted to the linked cohorts, we applied inverse probability of selection weights (IPSW) to create a population representative of the full cohort. We used pooled logistic regression weighted by IPTW only or IPTW and IPSW to estimate treatment effects. Metabolic conditions were more prevalent in linked cohorts compared with the full cohort. Within the full cohort, the confounding-adjusted hazard ratio was 2.26 (95% CI: 2.07, 2.49) comparing initiation of antipsychotics with initiation of control medications. Within the linked cohorts, a different magnitude of association was obtained without adjustment for selection, whereas applying IPSW resulted in point estimates similar to the full cohort’s (e.g., an adjusted hazard ratio of 1.63 became 2.12). Linked database studies may generate biased estimates without proper adjustment for potential selection bias.
Rural-Urban Differences in Maternal Mortality Trends in the United States, 1999–2017: Accounting for the Impact of the Pregnancy Status Checkbox
Authors: Rossen Lauren M , Ahrens Katherine A , Womack Lindsay S , Uddin Sayeedha F G , Branum Amy M
Published: December 2021

It has been difficult to measure rural-urban differences in maternal mortality ratios (MMRs) in the United States in recent years because of the incremental adoption of a pregnancy status checkbox on the standard US death certificate. Using 1999–2017 mortality and birth data, we examined the impact of the pregnancy checkbox on MMRs according to urbanicity of residence (large urban area, medium/small urban area, or rural area), using log-binomial regression models to predict trends that would have been observed if all states had adopted the checkbox as of 1999. Implementation of the checkbox resulted in an average estimated increase of 7.5 maternal deaths per 100,000 live births (95% confidence interval (CI): 6.3, 8.8) in large urban areas (a 76% increase), 11.6 (95% CI: 9.6, 13.6) in medium/small urban areas (a 113% increase), and 16.6 (95% CI: 12.9, 20.3) in rural areas (a 107% increase), compared with MMRs prior to the checkbox. Assuming that all states had the checkbox as of 1999, demographic-factor–adjusted predicted MMRs increased in rural areas, declined in large urban areas, and did not change in medium/small urban areas. However, trends and urban-rural differences were substantially attenuated when analyses were limited to direct/specific causes of maternal death, which are probably subject to less misclassification. Accurate ascertainment of maternal deaths, particularly in rural areas, is important for reducing disparities in maternal mortality.
Tissue Stromal Vascular Fraction Improves Early Scar Healing: A Prospective Randomized Multicenter Clinical Trial
Authors: van Dongen Joris A , van Boxtel Joeri , Uguten Mustafa , Brouwer Linda A , Vermeulen Karin M , Melenhorst Wynand B , Niessen Frank B , Harmsen Martin C , Stevens Hieronymus P , van der Lei Berend
Published: December 2021

Background

Wound healing and scar formation depends on a plethora of factors. Given the impact of abnormal scar formation, interventions aimed to improve scar formation would be most advantageous. The tissue stromal vascular fraction (tSVF) of adipose tissue is composed of a heterogenous mixture of cells embedded in extracellular matrix. It contains growth factors and cytokines involved in wound-healing processes, eg, parenchymal proliferation, inflammation, angiogenesis, and matrix remodeling.

Objectives

The aim of this study was to investigate the hypothesis that tSVF reduces postsurgical scar formation.

Methods

This prospective, double-blind, placebo-controlled, randomized trial was conducted between 2016 and 2020. Forty mammoplasty patients were enrolled and followed for 1 year. At the end of the mammoplasty procedure, all patients received tSVF in the lateral 5 cm of the horizontal scar of 1 breast and a placebo injection in the contralateral breast to serve as an intrapatient control. Primary outcome was scar quality measure by the Patient and Observer Scar Assessment Scale (POSAS). Secondary outcomes were obtained from photographic evaluation and histologic analysis of scar tissue samples.

Results

Thirty-four of 40 patients completed follow-up. At 6 months postoperation, injection of tSVF had significantly improved postoperative scar appearance as assessed by the POSAS questionnaire. No difference was observed at 12 months postoperation. No improvement was seen based on the evaluation of photographs and histologic analysis of postoperative scars between both groups.

Conclusions

Injection of tSVF resulted in improved wound healing and reduced scar formation at 6 months postoperation, without any noticeable advantageous effects seen at 12 months.

Level of Evidence: 2
Expanding Well-Being by Participating in Grassroots Innovations: Using the Capability Approach to Explore the Interest of Alternative Food Networks for Community Social Services
Authors: Belda-Miquel Sergio
Published: December 2021

Grassroots social innovations are citizen-led initiatives that develop bottom-up solutions to societal challenges. Alternative food networks (AFNs) are innovations which propose alternative schemes for distribution and consumption of food—such as community-based agriculture or food cooperatives—which can improve the well-being of participants. Its potential for social work and social services has been recognised, but remains underexplored. This paper proposes a theoretical framework based on the capability approach in order to explore the impacts, drivers and factors at play in the expansion of well-being in participants in AFNs. This framework is applied to address seven cases of different kind of AFNs in Valencia (Spain) and to explore implications and strands of action so community social services can make use of AFNs. The study draws on information from thirteen interviews with participants of AFNs, local experts and policymakers; from secondary sources and from participant observation. It deductively uses the categories in the framework and inductively identifies specific capabilities, drivers and factors. The results show that AFNs expand well-being in several aspects of human experience. They are highly diverse, from more reformist to more radical, so they can mobilise different publics. Social services can benefit from this impact and diversity.
Emotion and Reason in Political Language
Authors: Gennaro Gloria , Ash Elliott
Published: December 2021

This paper studies the use of emotion and reason in political discourse. Adopting computational-linguistics techniques to construct a validated text-based scale, we measure emotionality in six million speeches given in U.S. Congress over the years 1858–2014. Intuitively, emotionality spikes during times of war and is highest in speeches about patriotism. In the time series, emotionality was relatively low and stable in earlier years but increased significantly starting in the late 1970s. Across Congress members, emotionality is higher for Democrats, for women, for ethnic/religious minorities, for the opposition party and for members with ideologically extreme roll-call voting records.
A year of Covid-19: experiences and lessons learnt by small European island states—Cyprus, Iceland and Malta
Authors: Cuschieri Sarah , Pallari Elena , Hatziyianni Amalia , Sigurvinsdottir Rannveig , Sigfusdottir Inga Dora , Sigurðardóttir Árún Kristín
Published: December 2021

Background

COVID-19 became a global pandemic within weeks, as every country including small states and islands experienced a surge in cases. Small islands are known to face several challenges in the quest to curb the viral spread, but with the absence of land boarders and small population size, these factors should have played to their advantage to minimize the spread. The aim of this article was to compare and contrast the COVID-19 situation, restrictions, preparedness, management and the healthcare systems between the small population island states of Cyprus, Iceland and Malta.

Methods

Data were obtained from Ministry of Health websites and COVID dashboards of the three respective Island states in Europe. Comparisons were made between the reported cases, deaths, excess deaths, years of life lost, swabbing rates, restrictive measures, vaccination roll-out and healthcare system structures.

Results

Cyprus and Malta contained the COVID-19 spread better than Iceland during the first wave. However, a significantly higher viral spread and mortality rates were observed in Malta during the second waves. Similar healthcare preparedness and services, restrictions and relaxation measures were implemented across the three islands with some exceptions. Covid-19 vaccination has initiated across all Islands with Malta leading the vaccination roll-out.

Conclusion

The small population size and island status proved to be an asset during the first wave of COVID-19, but different governance approaches led to a different COVID-19 outcomes, including high mortality rates during the transition phases and the subsequent waves.
Interpretable network propagation with application to expanding the repertoire of human proteins that interact with SARS-CoV-2
Authors: Law Jeffrey N , Akers Kyle , Tasnina Nure , Santina Catherine M Della , Deutsch Shay , Kshirsagar Meghana , Klein-Seetharaman Judith , Crovella Mark , Rajagopalan Padmavathy , Kasif Simon , Murali T M
Published: December 2021

Background

Network propagation has been widely used for nearly 20 years to predict gene functions and phenotypes. Despite the popularity of this approach, little attention has been paid to the question of provenance tracing in this context, e.g., determining how much any experimental observation in the input contributes to the score of every prediction.

Results

We design a network propagation framework with 2 novel components and apply it to predict human proteins that directly or indirectly interact with SARS-CoV-2 proteins. First, we trace the provenance of each prediction to its experimentally validated sources, which in our case are human proteins experimentally determined to interact with viral proteins. Second, we design a technique that helps to reduce the manual adjustment of parameters by users. We find that for every top-ranking prediction, the highest contribution to its score arises from a direct neighbor in a human protein-protein interaction network. We further analyze these results to develop functional insights on SARS-CoV-2 that expand on known biology such as the connection between endoplasmic reticulum stress, HSPA5, and anti-clotting agents.

Conclusions

We examine how our provenance-tracing method can be generalized to a broad class of network-based algorithms. We provide a useful resource for the SARS-CoV-2 community that implicates many previously undocumented proteins with putative functional relationships to viral infection. This resource includes potential drugs that can be opportunistically repositioned to target these proteins. We also discuss how our overall framework can be extended to other, newly emerging viruses.
Myth-busting the provider-user relationship for digital sequence information
Authors: Scholz Amber Hartman , Lange Matthias , Habekost Pia , Oldham Paul , Cancio Ibon , Cochrane Guy , Freitag Jens
Published: December 2021

Background

The United Nations Convention on Biological Diversity (CBD) formally recognized the sovereign rights of nations over their biological diversity. Implicit within the treaty is the idea that mega-biodiverse countries will provide genetic resources and grant access to them and scientists in high-income countries will use these resources and share back benefits. However, little research has been conducted on how this framework is reflected in real-life scientific practice.

Result

Currently, parties to the CBD are debating whether digital sequence information (DSI) should be regulated under a new benefit-sharing framework. At this critical time point in the upcoming international negotiations, we test the fundamental hypothesis of provision and use of DSI by looking at the global patterns of access and use in scientific publications.

Conclusion

Our data reject the provider-user relationship and suggest a far more complex information flow for DSI. Therefore, any new policy decisions on DSI should be aware of the high level of use of DSI across low- and middle-income countries and seek to preserve open access to this crucial common good.
Sexual health in a new cultural context: a resource for international students in regional Australia
Authors: MacPhail Catherine , Stratten Maddison
Published: December 2021

A large number of international students enrol in Australian higher education and contribute to Australia’s multicultural population. Diverse cultural backgrounds and life experiences impact international students’ knowledge of sexual health and healthy relationships. Along with unfamiliarity of the Australian healthcare system, this may place international students at risk of poor sexual health. We explored the sexual health priorities of international students with 12 male and 16 female international students aged between 18 and 49 years, for the development of a sexual health and relationship information resource for international students. Interviews were recorded, transcribed verbatim and coded thematically in Nvivo 12. Students noted that cultural norms about sex inhibited their ability to access information and they had concerns about their relationship behaviours within the Australian cultural context. Some participants noted challenges with accessing information and care and were enthusiastic about increasing international student access to reliable information and access to services. Based on the findings from these interviews, we developed a resource specifically for international students and evaluated its design and content through three focus group discussions with international students. This evaluation data informed refinements made to the resource. The resource Kit contains sexual health and relationship information and provides links to reputable online sexual health information. The Kit has been widely distributed to international students and is currently being further evaluated for use and acceptability.
Mutations in the ribosome biogenesis factor gene LTV1 are linked to LIPHAK syndrome, a novel poikiloderma-like disorder
Authors: Han Ji Hoon , Ryan Gavin , Guy Alyson , Liu Lu , Quinodoz Mathieu , Helbling Ingrid , Lai-Cheong Joey E ,   Genomics England Research Consortium, Barwell Julian , Folcher Marc , McGrath John A , Moss Celia , Rivolta Carlo
Published: December 2021

In the framework of the UK 100 000 Genomes Project, we investigated the genetic origin of a previously undescribed recessive dermatological condition, which we named LIPHAK (LTV1-associated Inflammatory Poikiloderma with Hair abnormalities and Acral Keratoses), in four affected individuals from two UK families of Pakistani and Indian origins, respectively. Our analysis showed that only one gene, LTV1, carried rare biallelic variants that were shared in all affected individuals, and specifically they bore the NM_032860.5:c.503A > G, p.(Asn168Ser) change, found homozygously in all of them. In addition, high-resolution homozygosity mapping revealed the presence of a small 652-kb stretch on chromosome 6, encompassing LTV1, that was haploidentical and common to all affected individuals. The c.503A > G variant was predicted by in silico tools to affect the correct splicing of LTV1’s exon 5. Minigene-driven splicing assays in HEK293T cells and in a skin sample from one of the patients confirmed that this variant was indeed responsible for the creation of a new donor splice site, resulting in aberrant splicing and in a premature termination codon in exon 6 of this gene. LTV1 encodes one of the ribosome biogenesis factors that promote the assembly of the small (40S) ribosomal subunit. In yeast, defects in LTV1 alter the export of nascent ribosomal subunits to the cytoplasm; however, the role of this gene in human pathology is unknown to date. Our data suggest that LIPHAK could be a previously unrecognized ribosomopathy.
Indications, Postoperative Management, and Long-term Prognosis of Crohn’s Disease After Ileocecal Resection: A Multicenter Study Comparing the East and West
Authors: Arkenbosch Jeanine H C , Mak Joyce W Y , Ho Jacky C L , Beelen Evelien M J , Erler Nicole S , Hoentjen Frank , Bodelier Alexander G L , Dijkstra Gerard , Romberg-Camps Mariëlle , de Boer Nanne K H , Stassen Laurents P S , van der Meulen Andrea E , West Rachel , van Ruler Oddeke , van der Woude Christien Janneke , Ng Siew C , de Vries Annemarie C
Published: December 2021

Background

The Crohn’s disease (CD) phenotype differs between Asian and Western countries and may affect disease management, including decisions on surgery. This study aimed to compare the indications, postoperative management, and long-term prognosis after ileocecal resection (ICR) in Hong Kong (HK) and the Netherlands (NL).

Methods

CD patients with primary ICR between 2000 and 2019 were included. The endpoints were endoscopic (Rutgeerts score ≥i2b and/or radiologic recurrence), clinical (start or switch of inflammatory bowel disease medication), and surgical recurrences. Cumulative incidences of recurrence were estimated with a Bayesian multivariable proportional hazards model.

Results

Eighty HK and 822 NL patients were included. The most common indication for ICR was penetrating disease (HK: 32.5%, NL: 22.5%) in HK vs stricturing disease (HK: 32.5%, NL: 48.8%) in the NL (P < .001). Postoperative prophylaxis was prescribed to 65 (81.3%) HK patients (28 [35.0%] aminosalicylates [5-aminosalicylic acid]; 30 [37.5%] immunomodulators; 0 biologicals) vs 388 (47.1%) NL patients (67 [8.2%] 5-aminosalicylic acid; 187 [22.8%] immunomodulators; 69 [8.4%] biologicals; 50 [6.1%] combination therapy) (P < .001). Endoscopic or radiologic evaluation within 18 months was performed in 36.3% HK vs 64.1% NL (P < .001) patients. No differences between both populations were observed for endoscopic (hazard ratio [HR], 0.53; 95% confidence interval [CI], 0.24-1.21), clinical (HR, 0.91; 95% CI, 0.62-1.32), or surgical (HR, 0.61; 95% CI, 0.31-1.13) recurrence risks.

Conclusion

The main indication for ICR in CD patients is penetrating disease in HK patients and stricturing disease in NL patients. Although considerable pre- and postoperative management differences were observed between the two geographical areas, the long-term prognosis after ICR is similar.
Risks of Cardiovascular Events in Patients With Inflammatory Bowel Disease in China: A Retrospective Multicenter Cohort Study
Authors: Fang Leilei , Gao Han , Gao Xiang , Wu Wei , Miao Yinglei , Zhang Hongjie , Guleng Bayasi , Zhang Hu , Wang Yufang , Li Mingsong , Yang Hong , Gao Xiang , Liang Jie , Cao Qian , Shen Jun , Ran Zhihua , Wu Kaichun , Qian Jiaming , Chen Minhu , Liu Zhanju
Published: December 2021

Background

Inflammatory bowel disease (IBD) is a complex chronic disorder characterized by systemic inflammation, which may cause abnormal state of coagulation, resulting in cardiac events. This study aimed to investigate the incidences and risks of cardiac events in patients with IBD in China.

Methods

A retrospective cohort study was performed comprising 1435 patients with IBD from 12 IBD centers in China. Cases were matched with 1588 eligible participants without IBD from 12 medical centers according to age, sex, and laboratory parameters.

Results

Patients with IBD in China exhibited significantly higher incidences of ischemic heart disease (IHD; coronary heart disease included) but lower frequencies of right bundle branch block and premature contraction than those of matched controls. The risk of IHD increased in patients with IBD, peaking at the age of 18-35 years. Female patients with IBD were more likely to experience IHD than male patients. The C-reactive protein (CRP) levels and neutrophil count in the peripheral blood were positively related with the risk of IHD among patients with Crohn’s disease, whereas plasma fibrinogen levels were negatively related with the risk of IHD both in patients with Crohn’s disease and ulcerative colitis.

Conclusions

The risk of IHD is increased in patients with IBD, especially in young female patients with IBD when compared with matched non-IBD subjects. The CRP and plasma fibrinogen levels and neutrophil count in the peripheral blood may be potential predictors associated with the occurrence of IHD in patients with IBD. The study’s findings have significant implications for the management and prevention of cardiac events in patients with IBD.
Microscopic Colitis Is Associated With a Reduced Risk of Colorectal Adenoma and Cancer: A Meta-Analysis
Authors: Liu Yi-hui , Wu Zhen , Ding Ji-yuan , Shi Yu-dan
Published: December 2021

Background

The study sought to conduct a systematic review and meta-analysis of the risk of colorectal adenoma or cancer in patients with microscopic colitis (MC).

Methods

A comprehensive literature search of PubMed and EMBASE databases was performed. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated to examine the effect of MC on the risk of colorectal adenoma or cancer.

Results

Twelve studies reporting the outcomes of 50 795 patients with MC were eligible for this meta-analysis. MC was negatively associated with the risk of colorectal adenoma compared with participants without MC (RR, 0.44; 95% CI, 0.33-0.58; P < .001; I2 = 87.3%). Also, the rate of colorectal cancer was lower in the patients with MC compared with the general population (RR, 0.62; 95% CI, 0.43-0.89; P = .01; I2 = 91.6%). In addition, sensitivity and subgroup analyses indicated that the results were robust.

Conclusions

The present systematic review indicated that patients with MC may be associated with a lower risk of colorectal adenoma or cancer. The clinical data support the current professional society guideline. A surveillance colonoscopy program is not recommended as standard for patients with MC.
A dual-channel switching mechanism for uncertain NCSs against DoS attacks
Authors: Zhang Qingcao , Yin Xiuxia , Hu Songlin
Published: December 2021

In this paper, the stabilization mechanism, dual-channel switching mechanism, is investigated for a class of discrete-time networked control systems with parameter uncertainties and cyber attacks. A novel dual-channel switching mechanism is proposed against the denial-of-service attacks and achieve system asymptotic stability. The event-triggered scheme is considered to control unnecessary data communications. Based on this, a memory-based event-triggered scheme is put forward to overcome the drawback of event-triggered scheme so that the system dynamic performance is greatly improved and the network resources are saved also. Using the Lyapunov theory and linear matrix inequality, two sufficient conditions of memoryless and memory-based closed-loop systems are, respectively, derived to guarantee the desired stability. Furthermore, the controller gain(s) and event-triggered matrix are co-designed. Finally, the effectiveness of the proposed method is verified by the pendulum system and the satellite control system.
Human neutralizing antibodies for SARS-CoV-2 prevention and immunotherapy
Authors: Zhou Dongyan , Zhou Runhong , Chen Zhiwei
Published: December 2021

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2 has been spreading worldwide since December 2019, resulting in the ongoing COVID-19 pandemic with 237 million infections and 4.8 million deaths by 11 October 2021. While there are great efforts of global vaccination, ending this pandemic has been challenged by issues of exceptionally high viral transmissibility, re-infection, vaccine-breakthrough infection, and immune escape variants of concern. Besides the record-breaking speed of vaccine research and development, antiviral drugs including SARS-CoV-2-specific human neutralizing antibodies (HuNAbs) have been actively explored for passive immunization. In support of HuNAb-based immunotherapy, passive immunization using convalescent patients’ plasma has generated promising evidence on clinical benefits for both mild and severe COVID-19 patients. Since the source of convalescent plasma is limited, the discovery of broadly reactive HuNAbs may have significant impacts on the fight against the COVID-19 pandemic. In this review, therefore, we discuss the current technologies of gene cloning, modes of action, in vitro and in vivo potency and breadth, and clinical development for potent SARS-CoV-2-specific HuNAbs.
Horror and Its Affects
Authors: Hick Darren Hudson
Published: December 2021

In this article, following a trajectory set out by Noël Carroll, Matt Hills, and Andrea Sauchelli, I propose a definition of horror, according to which something qualifies as a work of horror if and only if it centrally and demonstrably aims at provoking one or more of a particular set of negative affects. A catalog of characteristically negative affects is associated with horror—including terror, revulsion, the uncanny, and the abject—but which cannot be collapsed into any single affect. Further complicating matters is that the set appears to be constantly, if slowly, mutating, so that the affects aimed at in the horror of the 1920s do not entirely overlap with those aimed at horror today, or which we might expect horror to aim at a century from now. As such, while we use “horror” as a blanket term across eras, whether some work is a work of horror will always be time-indexed.
Weight loss and high-protein, high-fiber diet consumption impact blood metabolite profiles, body composition, voluntary physical activity, fecal microbiota, and fecal metabolites of adult dogs
Authors: Phungviwatnikul Thunyaporn , Lee Anne H , Belchik Sara E , Suchodolski Jan S , Swanson Kelly S
Published: December 2021

Canine obesity is associated with reduced lifespan and metabolic dysfunction, but can be managed by dietary intervention. This study aimed to determine the effects of restricted feeding of a high-protein, high-fiber (HPHF) diet and weight loss on body composition, physical activity, blood metabolites, and fecal microbiota and metabolites of overweight dogs. Twelve spayed female dogs (age: 5.5 ± 1.1 yr; body weight [BW]: 14.8 ± 2.0 kg, body condition score [BCS]: 7.9 ± 0.8) were fed a HPHF diet during a 4-wk baseline phase to maintain BW. After baseline (week 0), dogs were first fed 80% of baseline intake and then adjusted to target 1.5% weekly weight loss for 24 wk. Body composition using dual-energy x-ray absorptiometry and blood samples (weeks 0, 6, 12, 18, and 24), voluntary physical activity (weeks 0, 7, 15, and 23), and fresh fecal samples for microbiota and metabolite analysis (weeks 0, 4, 8, 12, 16, 20, and 24) were measured over time. Microbiota data were analyzed using QIIME 2. All data were analyzed statistically over time using SAS 9.4. After 24 wk, dogs lost 31.2% of initial BW and had 1.43 ± 0.73% weight loss per week. BCS decreased (P < 0.0001) by 2.7 units, fat mass decreased (P < 0.0001) by 3.1 kg, and fat percentage decreased (P < 0.0001) by 11.7% with weight loss. Many serum metabolites and hormones were altered, with triglycerides, leptin, insulin, C-reactive protein, and interleukin-6 decreasing (P < 0.05) with weight loss. Relative abundances of fecal Bifidobacterium, Coriobacteriaceae UCG-002, undefined Muribaculaceae, Allobaculum, Eubacterium, Lachnospira, Negativivibacillus, Ruminococcus gauvreauii group, uncultured Erysipelotrichaceae, and Parasutterella increased (P < 0.05), whereas Prevotellaceae Ga6A1 group, Catenibacterium, Erysipelatoclostridium, Fusobacterium, Holdemanella, Lachnoclostridium, Lactobacillus, Megamonas, Peptoclostridium, Ruminococcus gnavus group, and Streptococcus decreased (P < 0.01) with weight loss. Despite the number of significant changes, a state of dysbiosis was not observed in overweight dogs. Fecal ammonia and secondary bile acids decreased, whereas fecal valerate increased with weight loss. Several correlations between gut microbial taxa and biological parameters were observed. Our results suggest that restricted feeding of a HPHF diet and weight loss promotes fat mass loss, minimizes lean mass loss, reduces inflammatory marker and triglyceride concentrations, and modulates fecal microbiota phylogeny and activity in overweight dogs.
International family migration and the dual-earner model
Authors: Munk Martin D , Nikolka Till , Poutvaara Panu
Published: December 2021

We analyze couples’ joint decisions about emigration and labor force participation using survey data on Danish emigrants, combined with full population administrative data. Couples are most likely to emigrate if the male partner or both partners hold a college degree and least likely to emigrate if neither of the partners is college educated. Probability that a dual-earner couple emigrates increases with the primary earner’s income. In most couples, both partners work before emigration, while after migrating outside the Nordic countries almost half of the women stay at home. Survey responses reveal that men mainly migrate for work reasons and women for family reasons. Our findings suggest that the dual-earner model may not be strongly ingrained among emigrating couples. Instead, female labor force participation abroad varies widely between different destinations.
Compelled by the Court to Act on Climate Change: Bushfire Survivors for Climate Action Incorporated v Environment Protection Authority [2021] NSWLEC 92
Authors: Schuijers Laura
Published: December 2021

This analysis considers Bushfire Survivors for Climate Action Incorporated v Environment Protection Authority [2021] NSWLEC 92, in which an Australian environment protection authority was issued a mandamus to compel it to perform a public duty to develop instruments to ensure the protection of the environment from climate change. Brought by a group of climate activists affected by bushfire, it is the first successful action-forcing case of its kind in Australia. Cases that seek to fill the gaps in domestic governance regimes via the courts raise the issue of the role of the courts in advancing climate policy. They also demonstrate the importance of the rule of law, and the right of citizens to enforce the law against the government where it has lagged. In this article, I provide an overview of the case in light of these aspects, and additionally consider the role that climate science played in the courtroom.
Balancing Act: Precision Medicine and National Security
Authors: DiEuliis Diane , Giordano James
Published: December 2021

Developments in genetics, pharmacology, biomarker identification, imaging, and interventional biotechnology are enabling medicine to become increasingly more precise in “personalized” approaches to assessing and treating individual patients. Here we describe current scientific and technological developments in precision medicine and elucidate the dual-use risks of employing these tools and capabilities to exert disruptive influence upon human health, economics, social structure, military capabilities, and global dimensions of power. We advocate continued enterprise toward more completely addressing nuances in the ethical systems and approaches that can—and should—be implemented (and communicated) to more effectively inform policy to guide and govern the biosecurity and use of current and emerging bioscience and technology on the rapidly shifting global stage.
A Review of Genome-Based Precision Medicine Efforts Within the Department of Defense
Authors: Poon Lucas , Por Elaine D , Cho Hyun Joon , Oliver Thomas G
Published: December 2021

Introduction

Providing patient-specific clinical care is an expanding focus for medical professionals and researchers, more commonly referred to as personalized or precision medicine. The goal of using a patient-centric approach is to provide safer care while also increasing the probability of therapeutic success through careful consideration of the influence of certain extrinsic and intrinsic human factors in developing the patient care plan. Of increasing influence on patient care is the phenotype and genotype information gathered from employing various next-generation sequencing methods. Guided by and partnered with our civilian colleagues, clinical components within the DoD are embracing and advancing genomic medicine in many facets—from the bench to the bedside—and in many therapeutic areas, from Psychiatry to Oncology. In this PubMed-based review, we describe published clinical research and interventions within the DoD using genome-informed data and emphasize precision medicine efforts in earlier stages of development with the potential to revolutionize the approach to therapeutics.

Materials and Methods

The new PubMed database was searched for articles published between 2015 and 2020 with the following key search terms: precision medicine, genomic, pharmacogenetic, pharmacogenomic, US military, and Department of Defense.

Results

Eighty-one articles were retrieved in our initial search. After screening the abstracts for studies that only involved direct testing of (or clinical interaction with) active duty, Reserve, National Guard, or civilian personnel working within the DoD and excluding any epidemiological or microbial isolation studies, seven were included in this review.

Conclusion

There are several programs and studies within the DoD, which investigate or use gene-based biomarkers or gene variants to deliver more precise clinical assessment and treatment. These genome-based precision medicine efforts aim to optimize the clinical care of DoD beneficiaries, particularly service members in the operational environment.
Operating Room Waste Generated Across Otolaryngology Cases
Authors: Ryan Mathew T , Malmrose Jonathan , Riley Charles A , Tolisano Anthony M
Published: December 2021

Background

Hospital waste adds to the ecological footprint of the healthcare system, whereas inattention to recyclables may increase costs. The primary objective of this study was to assess the amount of recyclable and nonrecyclable intraoperative waste produced across representative otolaryngology surgical procedures.

Methods

Representative surgical cases across four otolaryngology subspecialties at a tertiary care military medical institution were prospectively identified. Waste was collected, divided, and weighed across two categories: recyclable and nonrecyclable. This study was performed in conjunction with a hospital-approved quality improvement project.

Results

The study included 22 otolaryngology surgeries performed across four otolaryngology subspecialties: facial plastics, pediatrics, otology, and head and neck oncology. Overall, 197.4 kg of waste was collected of which 40.2 kg (20%) was recyclable and 157.2 kg (80%) was nonrecyclable. An average of 1.8 kg of recyclable materials and 7.1 kg of nonrecyclable materials were collected per case.

Conclusion

This study supports that otolaryngology surgical procedures generate a significant amount of waste, a large component of which is recyclable. It highlights the need for proper disposal of this waste and the implementation of a recycling program at our institution with the potential for both ecologic and economic benefits.
Horizontally Acquired Cellulases Assist the Expansion of Dietary Range inPristionchusNematodes
Authors: Han Ziduan , Sieriebriennikov Bogdan , Susoy Vladislav , Lo Wen-Sui , Igreja Catia , Dong Chuanfu , Berasategui Aileen , Witte Hanh , Sommer Ralf J
Published: December 2021

Horizontal gene transfer (HGT) enables the acquisition of novel traits via non-Mendelian inheritance of genetic material. HGT plays a prominent role in the evolution of prokaryotes, whereas in animals, HGT is rare and its functional significance is often uncertain. Here, we investigate horizontally acquired cellulase genes in the free-living nematode model organism Pristionchus pacificus. We show that these cellulase genes 1) are likely of eukaryotic origin, 2) are expressed, 3) have protein products that are secreted and functional, and 4) result in endo-cellulase activity. Using CRISPR/Cas9, we generated an octuple cellulase mutant, which lacks all eight cellulase genes and cellulase activity altogether. Nonetheless, this cellulase-null mutant is viable and therefore allows a detailed analysis of a gene family that was horizontally acquired. We show that the octuple cellulase mutant has associated fitness costs with reduced fecundity and slower developmental speed. Furthermore, by using various Escherichia coli K-12 strains as a model for cellulosic biofilms, we demonstrate that cellulases facilitate the procurement of nutrients from bacterial biofilms. Together, our analysis of cellulases in Pristionchus provides comprehensive evidence from biochemistry, genetics, and phylogeny, which supports the integration of horizontally acquired genes into the complex life history strategy of this soil nematode.
SAPHO syndrome and pustulotic arthro-osteitis
Authors: Kishimoto Mitsumasa , Taniguchi Yoshinori , Tsuji Shigeyoshi , Ishihara Yoko , Deshpande Gautam A , Maeda Keizo , Okada Masato , Komagata Yoshinori , Kobayashi Satomi , Okubo Yukari , Tomita Tetsuya , Kaname Shinya
Published: December 2021

Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis (SAPHO) syndrome is a rare inflammatory osteoarticular disorder, which encompassed many diseases, including pustulotic arthro-osteitis (PAO). Musculoskeletal manifestations, including osteitis, synovitis, and hyperostosis, are the hallmarks of the SAPHO syndrome and affect a variety of regions of the body. Recent survey indicated that more than 80% of cases of SAPHO syndrome in Japan were PAO, originally proposed by Sonozaki et al. in 1981, whereas severe acne was the most commonly reported skin ailment amongst participants with SAPHO syndrome in Israel. Prevalence of SAPHO syndrome remains unavailable, whereas the prevalence of palmoplantar pustulosis (PPP) was reported to be 0.12% in Japan, and 10–30% of patients with PPP had PAO. SAPHO syndrome and PAO are predominantly found in patients in the third through fifth decades of life, and a female predominance is seen in both groups. The diagnosis is typically made by a rheumatologist or dermatologist. Identification of a variety of the clinical, radiological, and laboratory features outlined, as well as diagnostic criteria, are used to make the diagnosis. Goals of treatment seek to maximize health-related quality of life, preventing structural changes and destruction, and normalizing physical function and social participation. Finally, we review the non-pharmacological and pharmacological managements.