bluuebunny/crossref_metadata_2025 huggingface dataset:
The Red Army and the Population in the Combat Operations during the Initial Stage of the Great Patriotic War in the Donbass and Lower Don: Basic Forms and Practices of Interaction
Authors:   Southern Scientific Center of the Russian Academy of Sciences, Krinko E. F.
Published: January 2025

The article examines the following topics: firstly, the direct participation in fighting of the residents
of the Donbass and the Lower Don, drafted into the field forces by mobilization or on a voluntary basis (as part
of rifle, cavalry and other units of the Red Army, units of the people’s militia, fighter battalions and other armed
formations); secondly, the creation of defensive structures and other military facilities; thirdly, the assistance to
wounded soldiers and commanders of the Red Army (including recovering from the battlefield and care for military
personnel in hospitals); fourthly, the work at defense industry enterprises, procurement of fresh vegetables
and herbs, fulfilling other orders of the active army; and finally, the raising funds for the defense fund and warm
clothing for Red Army soldiers and other forms of interaction. The basis of interaction was the patriotic motivation
of the majority of the population, along with the use of mobilization mechanisms implemented by the authorities
and public organizations. At the same time, the practical implementation of such interaction was accompanied
by certain restrictions, material damage and even direct victims among the population. On the other hand, the
documents also record manifestations of anti-Soviet sentiment among some residents of the front-line regions.The main sources for this research include the documents from the Central Archive of the Ministry of Defense of
the Russian Federation, the State Archive of the Rostov Region, the Center for the Documentation of the Contemporary
History of the Rostov Region, publications of documents and memories of eyewitnesses of the events,
including those recorded directly by the author.
Turkish Vector in Social and Political Life of the North Caucasian Migrants in the 1920–1940s
Authors:   Institute of Ethnology and Anthropology, Russian Academy of Sciences, Babich I. L.
Published: January 2025

The aim of this article is to study the role of Turkey in the formation and further development of the socio-
political life of North Caucasian migrants in the 1920s–1940s. in the Europe This study was based on archival
materials of France and Russia. The history of relations between the Turkish authorities and Turkish citizens, on
the one hand, and the mountain people of the North Caucasus, on the other, includes three stages: the first stage
(1919–1921), the second stage (1926–1929), the third stage (1930s). The criteria for these stages: the attitude of
Turkish authorities to the USSR, to the North Caucasian peoples, the role of the descendants of the Circassian
peoples (Muhajirs), who settled in Turkey during the 19th century. The author studies the role of the Turkish citizen
— the grandson of Imam Shamil — Said Shamil. In 1926, he organized the People’s Party of the Caucasus
Mountaineers, which included representatives of the peoples of the North Caucasus who settled in Europe in
the 1920s. During the Second World War and after War the peoples of the North Caucasus, who lived in Europe,
moved to Turkey for residence. The author concludes that Turkey during this period was not interested in supporting
the North Caucasian peoples in their struggle for independence.
An Epistolary Novel: The Interaction Between Government and Civil Society through Letters
Authors:   S. А. Yesenin Ryazan State University, Popova A. D. , Popova O. D. ,   S. А. Yesenin Ryazan State University
Published: January 2025

The article investigates citizens’ letters addressed to officials in the second half of the 20th century.
The authors show that people perceived the government as a multicomponent structure. People addressed their
letters to the leaders of the Soviet State, to the central government and local authorities, to various social institutions,
as well as to journals and newspapers. Soviet citizens often addressed their letters both to the central newspapers such as Trud (Labour), Izvestiia (News), Krokodil (Crocodile) and to local ones. Soviet citizens wrote
their letters hoping to solve their everyday problems as well as in response to propaganda and agitation. To understand
the specifics of this epistolary discourse, one should investigate both the issues discussed in a letter
and its format: politeness formulas, emotions, arguments, etc. The research shows that Soviet citizens treated
authorities through the prism of social and political guidelines and patterns. The chronological analysis enables
the researchers to explore the evolution of the interaction between citizens and authorities and the dynamics of
citizens’ confidence in the actions of the government. The research shows that in the second half of the 20th century
citizens viewed the actions of the government with growing criticism. In their letters, citizens did not express
requests, they criticized. The ideology experienced a crisis, the gap between common people and authorities
was growing, letter writers were more demanding, social trust was gradually declining to increase during the Era
of Perestroika. The authors conclude that social transformations had a great impact on the interaction between
society and authorities.
Doctors’ Eyes: Perception of Healthcare Services During the COVID-19 Pandemic: Experience in Poznań, Poland
Authors: Tuczyńska Magdalena , Baum Ewa
Published: January 2025

Objectives: The outbreak of the COVID-19 pandemic impacted many aspects of life among various professionalgroups. Healthcare workers were the first line of help and the most vulnerable to being infected with the SARS-CoV2 virus. The efforts to counter the impact of the pandemic were not helped by shortages of staff and personal protective equipment, which affected the doctors’ comfort as well as the patients’ access to quality healthcare services. This study investigates the perception of healthcare services during the COVID-19 pandemic from the perspective of medical doctors living in Poznań, Poland.
Material and methods: The questionnaire was distributed in paper form among doctors and dentists. Responses were received from 72 respondents, including 63 women and 9 men. The survey was conducted during Poland’s third wave of the COVID-19 pandemic.
Results: Statistically significant correlations were found between access and quality of healthcare services; appointment time and online mode of admission; access to PPE and quality of healthcare services; work comfort and access to PPE; and work comfort and quality of healthcare services.
Conclusions: The work of doctors and dentists during the COVID-19 pandemic has changed their perceptionsof the accessibility and quality of healthcare services. The opinions of doctors and other healthcare providers, as the professional group closest to the hardships of the pandemic, should be highlighted and widely considered.
Características de qualidade do mel de abelha (Apis mellífera L.) da mesorregião Oeste Potiguar do estado do Rio Grande do Norte, Brasil
Authors:   , Mesquita Luciene Xavier de
Published: January 2025

Verificou-se os méis produzidos por Apis mellifera L. na Mesorregião do Oeste Potiguar - RN Brasil cumprem as especificações determinadas pelas legislações. Foram analisadas 73 amostras de mel determinando os parâmetros físico-químicos, testes qualitativos (Fiehe, fermento diastásico e Lugol), sensoriais e microbiológicos, as amostras foram coletadas nas casas de mel, em torno de 500 ml por apicultor e analisadas 48 horas após cada coleta. O período de coleta foi de março de 2008 a setembro 2009. Os resultados obtidos foram: a cor com predominância de 36% de âmbar claro, umidade (20,16%±3,44%), atividade de água (0,620±0,027%), sólidos (0,33±0,311%), cinzas (0,15±0,086%), densidade (1,40g.cm-1±0,034), pH de (3,39±0,49), acidez (38,07 meq/kg±16,45), açúcares (63,24%±10,25), sacarose (5,674%±1,02), HMF (10,94 mg/kg±4,91), Lund (0621+0,257%) e condutividade (0,36 mS/cm±0,125); resultados negativos para os testes qualitativos, 18 amostras com crescimento bolores e leveduras e 15 amostras com coliformes totais e fecais. Os valores HMF, acidez livre, cor, cinzas estiveram de acordo com os regulamentos do BRASIL (2000), Codex (2001) e o MERCOSUL (GMC 89/99) e a condutividade, açúcares de acordo com o Codex (2001); 18 amostras tiveram valores maiores que 100 UFC/g para bolores e leveduras e 15 tiveram valores acima de <3NMP/g contrapondo o MERCOSUL (GMC 89/99). As características das amostras de méis produzidas que não estão em conformidade com as normas indicam a necessidade de reformulação desses padrões e os méis que tiveram crescimento microbiano sugerem a necessidade de aplicação das boas práticas de apícolas.
Efeitos do ambiente sobre as variáveis fisiológicas e perda de calor latente em cutias (Dasyprocta aguti; Linnaeus, 1766) em uma região semi-árida
Authors:   , Queiroz João Paulo Araújo Fernandes de
Published: January 2025

Este estudo objetivou avaliar os efeitos do ambiente sobre o comportamento das variáveis fisiológicas de cutias (Dasyprocta aguti; Linnaeus, 1766) e determinar a perda de calor por evaporação desse roedor. A freqüência respiratória sofreu efeito significativo (P<0,05) do sexo, sendo os machos aqueles com a média mais elevada. Apenas a idade apresentou significância (P<0,05) sobre a temperatura retal, com os filhotes exibindo uma temperatura média superior aos adultos. A temperatura timpânica direita sofreu efeito do sexo ao nível de significância de 5% de probabilidade, com as fêmeas apresentando as temperaturas médias mais elevadas. Nos diferentes sexos e faixas etárias, a temperatura timpânica direita manteve-se superior à temperatura timpânica esquerda. A temperatura da superfície corporal sofreu efeito significativo (P<0,05) da interação (Sexo com Idade), ocorrendo efeito do animal somente enquanto a temperatura do globo negro à sombra manteve-se abaixo de 32o C. Resultados preliminares sobre a distribuição da temperatura da superfície corporal demonstraram efeito significativo (P<0,01) das regiões corporais avaliadas, com as orelhas (37,40±0,04o C) e as patas posteriores (35,89±0,04o C) apresentando temperaturas médias mais elevadas. A análise histológica da pele não revelou a presença de glândulas sudoríparas. Os mecanismos latentes de termólise não sofreram efeito significativo do sexo e da idade e não mostraram correlação significativa com as variáveis meteorológicas. A média e o desvio padrão da média para a perda de calor por evaporação na cutia foi 10,76±6,67 W.m-2.
Mesenchymal Stem Cell-conditioned Medium Attenuated CoCl2-induced Injury of Renal Tubular Epithelial Cells by Inhibiting NCOA1, HIF-1α, and Sox9
Authors: Liu Yiping , Lin Yongda , Wang Ziqiang , Tang Wenzhuang , Liao Chunling , Zhou Tianbiao
Published: January 2025

Backgrounds:

Renal interstitial fibrosis (RIF) constitutes the ultimate pathological alteration in
nearly all chronic kidney diseases (CKD). Mesenchymal stem cell conditioned medium (MSC-CM) exhibits
an alleviating impact on renal fibrosis; however, the underlying mechanism remains unclear. The objective of
this study was to explore whether MSC-CM regulates the expression of α-smooth muscle actin (α-SMA),
Transforming growth factor-β1 (TGF-β1), Hypoxia-inducible factor-1α (HIF-1α), Nuclear receptor coactivators
(NCOA1), and SRY-related high mobility (Sox9).

Methods:

Rat renal tubular epithelial cells (RTECs), NRK-52E, were treated with diverse concentrations of
Cobalt chloride (CoCl2) for 24 hours. The survival rate and protein expression of NRK-52E cells exposed to
different concentrations of CoCl2 were determined to identify the final concentration. Three groups of
NRK-52E cells were employed in the experiment: the normal control group, the 400 μM CoCl2 group, and the
MSC-CM + 400 μM CoCl2 group. The cell morphology was observed by an inverted phase contrast microscope
and scanning electron microscope, and the protein expressions of α-SMA, TGF-β1, HIF-1α, NCOA1,
and Sox9 were detected.

Result:

The microscopic findings demonstrated that MSC-CM was able to decrease the degree of cytochemical
hypoxia damage in NRK-52E cells induced by CoCl2. Immunofluorescence and Western blot analyses also
affirmed a similar tendency. The upregulation of α-SMA, TGF-β1, HIF-1α, NCOA1, and Sox9 triggered by
CoCl2 could be inhibited following MSC-CM intervention.

Conclusion:

Our findings indicate that MSC-CM exerts a protective effect on RTECs by down-regulating α-SMA,
TGF-β1, HIF-1α, NCOA1, and Sox9.
Design of VEGFR2 Inhibitors: Construction and Screening of Virtual
Compound Libraries
Authors: Luo Yixin , Hu Chunqi
Published: January 2025

Objective:

The current use of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2)
inhibitors is often limited by low selectivity and adverse side effects, highlighting the urgent need for
novel, highly selective agents targeting this receptor.

Methods:

Based on existing VEGFR-2 inhibitors, we employed computer-aided drug design
(CADD) techniques to develop a virtual compound library using active docking fragments. Molecular
docking was performed using the configuration of VEGFR-2 as the receptor protein(PDB:4ASD).
Comparative analysis and screening identified the most promising inhibitor, which was subsequently
validated through molecular dynamics simulations.

Results::

From the virtual library, 10 potential highly active inhibitors were identified. In particular,
Compound 9 demonstrated strong binding affinity with the protein configuration, forming four hydrogen
bonds during docking. The calculated CODOCKER energy was 39.7315 kcal/mol, with an
RMSD of 0.4634 nm and RMSF of 0.3234 nm. Compared to Sorafenib, Compound 9 exhibited superior
docking selectivity and activity.

Conclusion:

Computational analyses suggest that Compound 9 is a promising candidate as a highly
selective VEGFR-2 inhibitor. Nonetheless, due to the inherent limitations of in silico docking studies,
further chemical synthesis and experimental biological validation are required to confirm its
potential.
Unraveling the Mystery: COVID-19 and Diabetic Complications - A Journey from Pathophysiology to Treatment
Authors: Amanat Muhammed , Tandon Sapna , Singh Randhir
Published: January 2025

The connection between COVID-19 and DM unveils a multifaceted interplay that significantly
impacts disease severity and management strategies. Initial studies reveal that people with
DM had higher severity rates of COVID-19 due to the infection by SARS-CoV-2. The virus solely
induces hyperglycemia and, at the same time, profoundly influences the immune and inflammatory
reactions, increasing the rate of severe complications and death among diabetes patients.
Therefore, understanding the underlying mechanisms behind this interplay is critical for effective
treatment. Furthermore, COVID-19 also brings new factors to the equation of managing diabetes.
Although the virus thoroughly relies on the ACE2 receptor for viral entry, DPP4 is a substitute receptor.
However, glucose-lowering DPP4 inhibitors provide only a minor association with
COVID-19 vulnerability. Also, the SGLT2 inhibitors are contraindicated in certain conditions
with COVID-19, and hence, insulin is generally recommended as a first-line treatment for acute
glycemic control in hospitalized or critically ill COVID-19 patients, particularly those with severe
hyperglycemia or diabetic ketoacidosis. COVID-19-associated aggravating factors, such as cardiovascular
disease, chronic kidney disease, and neuropathy, predispose people with diabetes to severe
conditions. Thus, it is important to explore this speculation, and the present review aims to understand
this complex interaction during patient care models and specify the therapeutic approaches
to address this problematic convergence of two substantial health concerns.
Morphology and Distribution of Fat Globules in Osteomyelitis on Magnetic Resonance Imaging
Authors: Xie Li-Yuan , Cao Lei , Wu Wen-Juan , Liu Ji-Cun , Zhao Na , Zheng Yong-Li , Zhu Xiao-Na , Gao Bu-Lang , Han Gui-Fen
Published: January 2025

Introduction:

The purpose of this study was to investigate the morphology and distribution characteristics of fat globules in osteomyelitis on magnetic resonance
imaging (MRI).

Materials and Methods:

Patients with pathologically-confirmed osteomyelitis and MRI scans were retrospectively enrolled, and fat globules on the MRI images were
analyzed.

Results:

Among 103 patients with non-traumatic osteomyelitis, 75 were fat globule negative and 28 were positive. There was no statistically significant
difference in age and gender between patients with and without fat globules (p>0.05). The inflammatory indicators (CRP, ESR, WBC, and NEUT)
in the fat globule positive group were significantly higher (p<0.05) than those in the negative group. The lesions were mainly located in the long
bones of the limbs in patients with positive fat globules. Twenty-eight patients (27.2% or 28/103) were detected to have fat globules on MRI
images, including 20 males (71%) and 8 females (29%) aged 5-64 years (mean 16 years). The time from onset to MRI examination was 8 days to 4
months. The location of fat globules was in the tibia in 10 patients (35.7%), femur in 8 (28.6%), humerus in 4 (14.3%), radius in 2 (7.1%), ulna in 1
(3.6%), calcaneus in 1 (3.6%), sacrum in 1 (3.6%), and fibula in 1 patient (3.6%). On MRI imaging, 28 cases (100%) showed widely distributed
patches or tortuous and sinuous abnormal signals in the bone marrow. In 25 cases (89.2%), a grid-like abnormal signal was found in the
subcutaneous soft tissue. In 21 patients (75%), pus was found in the adjacent extraosseous soft tissues. Among 28 patients with fat globules, 17
patients (60.7%) had fat globules only in the adjacent extraosseous soft tissue, 6 patients (21.4%) had only intraosseous fat globules [including 5
cases with halo signs around the fat globules and 1 case (3.6%) with fat globules located at the edge of the pus cavity inside the bone without a
halo sign], and 5 patients (17.8%) had both intraosseous and extraosseous fat globules. Of 6 patients (21.4% or 6/28) with liquid levels, the liquid
level appeared outside the bone.

Conclusion:

The appearance of fat globules on MRI in patients with osteomyelitis indicates severe infection. Fat globules of osteomyelitis may present with
diverse shapes inside and outside the bone marrow as one of the MRI signs of osteomyelitis, with a probability of approximately 27.2%. They have
high specificity in diagnosing osteomyelitis and can be used for diagnosis and differential diagnosis.
Sonographic Features of Juvenile Fibroadenoma in Children-a Retrospective Study
Authors: Shi Jian , Chen Luzeng , Ye Jingming , Zhang Shuang , Zhang Hong , Shao Yuhong , Sun Xiuming
Published: January 2025

Aims:

Studies specifically examining the sonographic features of juvenile fibroadenoma in the pediatric population have not been documented. We aimed
to analyze sonograms of juvenile fibroadenoma in children.

Subjects and Methods:

Patients aged ≤ 18 years who underwent breast ultrasound examinations at our department and had pathologically proven juvenile fibroadenoma
from September 2002 to January 2022 were included in this study. Demographic data, clinical findings, and sonograms were retrospectively
analyzed. Patients were further divided into the puberty and post-puberty subgroups, and their results were compared.

Results:

A total of 24 girls aged 10-18 years with 27 masses diagnosed as juvenile fibroadenomas were identified. The diameter of the masses averaged 5.8
± 3.3 cm, with a range of 1.5-13.6 cm. Twenty-one (87.5%) patients had a single mass and 3 had double lesions. Over 80% of the lesions were
oval-shaped and encapsulated with circumscribed margins and parallel orientation. All masses showed internal hypoechogenicity, either uniform or
heterogeneous. For masses that had a diameter > 5 cm, screening with high-frequency transducers revealed no posterior acoustic features or
posterior shadowing. However, these features changed to posterior acoustic enhancement when the masses were re-evaluated using low-frequency
transducers. Ultrasonic color Doppler showed blood flow in 24 (88.9%) masses. There were no significant differences in the incidence and
sonographic features between the two subgroups.

Conclusion:

Most juvenile fibroadenomas in children are oval, circumscribed, encapsulated masses with detectable blood flow. All juvenile fibroadenomas
presented in this study exhibit internal hypoechogenicity with no posterior acoustic shadowing detected in any cases. Our findings suggest that
screening with low-frequency transducers should be performed for a mass that has a diameter > 5 cm.
A Comparison of the Diagnostic Value of Multiorgan Point-of-care Ultrasound between High-risk and Medium-to-low-risk Pulmonary Embolism Cases
Authors: Wu Weihua , Yu Zhenfei , Cheng Kang , Xie Manqiong , Fang Shunjin , Zhu Jianfeng
Published: January 2025

Objective:

This study aimed to explore the diagnostic value of multiorgan (heart, lungs, blood vessels) point-of-care ultrasound (PoCUS) in patients with
high-risk and medium-to-low-risk pulmonary embolism (PE).

Methods:

Clinical data of 92 patients with suspected PE, admitted to Hangzhou TCM Hospital affiliated with Zhejiang Chinese Medical University from July
2021 to June 2023, were retrospectively analyzed. According to hemodynamic status, patients were divided into the high-risk (n=28) and the
medium-to-low-risk groups (n=64). Using computed tomography (CT) and pulmonary angiography (CTPA) as the gold standard, all patients
underwent multiorgan PoCUS examination. The sensitivity, specificity, and accuracy of different methods for diagnosing PE, as well as the time
difference between multiorgan PoCUS examination and CTPA, were compared. Differences in measurement values of relevant indicators in all
groups were analyzed.

Results:

In the high-risk group of patients, CTPA identified 15 cases of PE. In contrast, the PoCUS examination confirmed PE diagnosis in 14 cases (true
positive), while 10 cases were diagnosed as true negative, one case as false negative, and three cases as false positive. In the medium-to-low-risk
group, CTPA identified 50 patients with PE, while multiorgan PoCUS confirmed PE diagnosis in 33 cases (true positive), and identified 9 true
negative, 17 false negative, and 5 false positive PE cases. Kappa test of the consistency between the results of multiorgan PoCUS and CTPA
showed that multiorgan PoCUS had higher sensitivity, negative predictive value, and accuracy in the high-risk group compared to the medium-tolow-
risk group (p<0.05). Cohen's Kappa value of the high-risk group was 0.710, indicating moderate consistency between PoCUS and CTPA
results, while Cohen's Kappa value of 0.231 for the medium and low-risk group indicated poor consistency. There was a significant difference in
ultrasound parameters between the high-risk and the medium-to-low-risk group (p<0.05). The time required for multiorgan PoCUS in both groups
was significantly shorter than that for the CTPA. There was no significant difference in the time required for PoCUS between the two groups
(p>0.05).

Conclusion:

Multiorgan PoCUS has been found to have higher sensitivity and accuracy in diagnosing patients with high-risk PE compared to those with
medium-to-low-risk PE, and a shorter imaging time compared to CTPA.
Intranasal Sodium Valproate: A New Frontier in Epilepsy Therapy
Authors: Khan Imran , Singh Aditya , Ansari Vaseem Ahamad , Ansari Tarique Mahmood , Ahsan Farogh
Published: January 2025

Epilepsy, a prevalent neurological disorder, affects approximately 1% of the Indian
population, presenting a significant challenge in clinical management. Noninvasive treatment options are actively being explored, with nose-to-brain drug delivery emerging as a promising approach for effective epilepsy control. This comprehensive review delves into the potential of intranasal nanotherapy, focusing on its applicability in managing epilepsy. A key component of this
review is an in-depth analysis of sodium valproate (SVS), a widely prescribed antiepileptic drug
known for its effectiveness in treating epilepsy as well as various mental health conditions, such
as bipolar disorder and migraine. The review examines the chemical structure, pharmacological
properties, and diverse therapeutic uses of SVS, highlighting its role as a GABA amplifier. Special attention is given to emerging nanoparticle-based intranasal formulations, which show promise for enhanced brain delivery and improved therapeutic outcomes in epilepsy treatment. Furthermore, it discusses the associated compounds in SVS and their potential impact on its pharmacological profile, including possible side effects, drug interactions, and adverse effects. The importance of precise dosing and rigorous medical monitoring is emphasized to minimize risks. Detailed analyses of the anatomy of the nasal cavity, drug deposition mechanisms, and mucociliary
clearance are carried out to illustrate the challenges in optimizing drug delivery via this route. The
unique pharmacokinetic and pharmacodynamic features of divalproex sodium, a formulation of
valproic acid, are explored, with insights into its absorption, distribution, metabolism, and excretion (ADME) characteristics. The review also highlights its broad-spectrum antiepileptic effects
and regulation of the GABAergic system, offering a comprehensive understanding of its therapeutic efficacy. The findings underscore the potential of intranasal nanotherapies as an innovative
and effective strategy for epilepsy management.
Transforming Polymers: Innovative Physical and Chemical Modification Techniques for Advanced Functional Applications
Authors: Panda Pratikeswar , Mohapatra Rajaram
Published: January 2025

Polymer modification encompasses a diverse array of techniques aimed at enhancing the
physical and chemical properties of polymers, thereby expanding their applicability across various
fields. Physical modification methods include self-assembled monolayers, radiation-induced surface
modifications, UV irradiation, γ-irradiation, and laser-induced surface modifications. These techniques primarily focus on altering surface properties and enhancing characteristics such as strength,
toughness, and thermal stability through non-chemical means. Chemical modification methods, on
the other hand, involve reactions that change the polymer’s chemical structure. Common chemical
reactions used in polymer modification include PEGylation, conjugation, wet chemical oxidation
treatments, and plasma treatments. These processes introduce new functional groups, improve compatibility with other materials, and tailor properties like solubility, adhesion, and biodegradability.
Despite the significant advancements in polymer modification techniques, challenges such as maintaining polymer integrity, controlling modification precision, and ensuring scalability persist. This
review provides a comprehensive overview of both physical and chemical polymer modification
methods, discussing their mechanisms, applications, and the challenges involved, thereby highlighting their critical role in the development of advanced materials for industrial, biomedical, and environmental applications.
The Involvement of the NEAT1-1/miR-873-5p/GalNAcT-I Axis in the Development of Neuroblastoma
Authors: Hu Zhigang , Wang Huiming , Wang Juan , Fang Yanbin , Sun Chi , Yang Xiaofeng , Xu Weili
Published: January 2025

Background:

The most prevalent extracranial solid tumor in childhood is neuroblastoma (NB), which arises from undifferentiated neural crest cells. However,
the prognosis of this condition remains unfavorable, and the underlying mechanisms of its origin are still elusive. Therefore, this study aimed to
investigate the specific mechanism underlying NEAT1-1 in NB.

Methods:

In this study, the expressions of NEAT1-1, miR-873-5p, and GalNAcT-I were analyzed by real-time quantitative polymerase chain reaction (qRTPCR)
and Western blot (WB). Then, CCK-8 assays were conducted to evaluate the proliferation of NB cells. The Transwell assay was then
performed to evaluate the invasion and migration of NB cells. Further, flow cytometry was utilized for the detection of cell apoptosis. Furthermore,
the luciferase reporter gene assay was carried out to investigate the relationship between NEAT1-1 and miR-873-5p, as well as between
miR-873-5p and GalNAcT-I. In contrast, an RNA-pull-down assay was conducted to confirm the regulatory relationship between NEAT1-1 and
miR-873-5p. The effect of NEAT1-1 on tumor growth in vivo was detected in the BALB/c nude mice model.

Results:

The qRT-PCR analysis revealed a significantly upregulated expression of NEAT1-1 in NB tumors compared to adjacent non-tumor tissue specimens. Suppression of NEAT1-1 resulted in the inhibition of tumor characteristics and induction of apoptosis in NB cells through the targeted regulation of miR-873-5p. Moreover, NEAT1-1 exerted its regulatory effect on GalNAcT-I protein levels by acting as a sponge for miR-873-5p in NB cells. Importantly, the downregulation of NEAT1-1 effectively suppressed tumor growth in vivo.

Conclusion:

Collectively, our findings suggest that the down-regulation of NEAT1-1 exerts a suppressive effect on NB progression by modulating the miR-873-5p/GalNAcT-I pathway, thereby providing novel insights into elucidating the underlying mechanisms of NB.
Formulation and In-Vitro Evaluation of Vildagliptin Microspheres Using Pectin and Xanthan Gum as Polymers
Authors: Manubolu Krishnaveni , Peeriga Raveesha
Published: January 2025

Introduction:

Vildagliptin is a dipeptidyl peptidase 4-related inhibitor that is often utilised in the treatment of type-2 diabetes. It is possible that sustained
therapeutic levels of vildagliptin for a prolonged length of time might be achieved by controlled release of the drug in the gastrointestinal system,
which would result in an improvement in the efficacy of treatment. Due to their high biocompatibility and biodegradability, biopolymers, such as
alginate (sodium), pectin, and xanthan gum, are frequently utilized in drug delivery systems. This is because these biopolymers are good
alternatives for the development of controlled-release formulations.

Aim:

This study aimed to formulate and in vitro evaluate the vildagliptin microsphere using pectin and xanthan gum.

Materials and Methods:

The delivery of vildagliptin was accomplished by the development of beads that were constituted of sodium alginate-pectin and sodium alginatexanthan
gum. Adjusting the proportions of sodium alginate, pectin, and xanthan gum resulted in the production of pH-sensitive beads throughout
the synthesis. This was accomplished through the use of a calcium chloride (CaCl2)-induced ionic gelation approach.

Results:

The FTIR revealed the compatibility of medicines and polymers. The synthesized beads were tested for scanning electron microscopy, differential
scanning calorimetry, drug content, swelling ratio, and in vitro dissolution analysis. The microscopic pictures showed beads of spherical shape and
mostly semi-spherical with a broken and rough surface. Swelling was found to be pH-dependent, indicating that water absorption might be minimal
in an acid medium and high in an alkaline pH condition. The in-vitro dissolving study depicted controlled drug release.

Conclusion:

This study recorded the successful formulation of vildagliptin microspheres using sodium alginate, pectin, and xanthan beads for the controlled
release of vildagliptin.
Corrigendum to: Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative Medicine
Authors: Dhanjal Daljeet Singh , Singh Reena , Sharma Varun , Nepovimova Eugenie , Adam Vojtech , Kuca Kamil , Chopra Chirag
Published: January 2025

The authors of the article titled "Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative
Medicine" (Dhanjal DS, Singh R, Sharma V, Nepovimova E, Adam V, Kuca K, Chopra C. Curr Med Chem. 2024;
31(13): 1646-1690. DOI: 10.2174/0929867330666230503144619. PMID: 37138422) [1] have made revisions to the references
in the text and the reference section. These updates have been made to ensure the integrity of the article. The updated
reference list can be found in the latest version of the article.

The authors apologize for any confusion or inconvenience caused.

The original article can be found online at: https://www.eurekaselect.com/article/131443
Evaluation of Learning Mathematics Economics and Business AE Class with Cipp Method
Authors: Larasati Dorothea , Islami Muhammad
Published: January 2025

One of the subjects or courses that cannot be avoided from the faculty of economics and business is economic and business mathematics courses. Learning economic and business mathematics courses will not be separated from errors during the learning process. This study examines the evaluation of learning in economic and business mathematics courses in AE class from the aspects of CIPP method (context, input, process, and product). The research method used in this research is quantitative with collection techniques through questionnaires and observations. The population in this study came with 25 respondents. The data analysis technique used is descriptive quantitative. The results showed that the learning evaluation of economic and business mathematics courses in AE Class received the “Good” with a percentage of 81.2%. This research shows that AE class economics and business courses affect the learning of AE class economic and business mathematics from various aspects. This research is useful for educational institutions to improve the learning system at the university.
An Analysis of The Determinants of Unemployment Rate in West Java
Authors: Rayhan Emir , Saputra Putu Mahardika Adi
Published: January 2025

Unemployment is a social and economic issue that affects economic stability and is quite seriously faced by developing countries, especially Indonesia. This is influenced by various interrelated factors, including average length of schooling, investment, minimum wage. This research aims to analyze the influence of average length of schooling, investment, minimum wage, sector industry, and COVID-19 on the unemployment rate in West Java Province for the period 2010-2022. This research uses a quantitative research approach and secondary data types. The analysis technique used to determine the factors that influence the unemployment rate uses panel data regression. The research results show that the average length of schooling has a negative and significant influence, the sector industry and COVID-19 have a positive and significant influence. Meanwhile, investment and minimum wages have no influence on the unemployment rate in West Java Province. The implications of the findings in this research are that the government needs to support industrial growth so that it can achieve a more inclusive labor market and increase cooperation with the private sector, academics and society regarding more effective and targeted policy implementation.
Determinants of Economic Growth in Java: Per Capita Expenditures, Population, and Contribution of Indonesian Democracy
Authors: Sari Windy Fabrila
Published: January 2025

The Golden Indonesia Vision 2045 targets sustainable, equitable and inclusive economic development, with an emphasis on the “Sustainable Economic Development” pillar. Java, as Indonesia's strategic region, is the highest contributor to the National Gross Domestic Product (GDP). In the 2019-2023 period, the global economic contraction due to the COVID-19 pandemic and the impact of simultaneous regional elections in Indonesia are challenges. This study examines the effect of per capita expenditure, population, and the Indonesian Democracy Index (IDI) on economic growth in Java. Using secondary data from six provinces and panel data regression analysis, the results show that per capita expenditure has a positive and significant effect on economic growth, while population has a negative and significant effect. IDI shows a positive but statistically insignificant relationship. The findings emphasize the importance of increasing purchasing power, population productivity through education and technology, and strengthening substantive democracy to achieve sustainable economic growth. This research provides insights for policy makers in optimizing regional potential to support Indonesia's national economic growth goals.
The Effect of Block Grants on the Level of Community Welfare Through Education Function Expenditure
Authors: Aqilla Cinantya Wara Dayinta  , Agus Suman
Published: January 2025

This research is motivated by the high transfer funds (DAU and DBH) and the high expenditure on education functions in East Java. The high transfer funds and education function expenditure have not been able to make East Java have a high HDI compared to other regions in Java. Therefore, this study aims to determine the effect of DAU and DBH on HDI through education function expenditure in cities and districts in East Java Province in 2018-2022. The data in this study are panel data sourced from the APBD realisation data of 29 districts and 9 in East Java Province published by the Directorate General of Fiscal Balance (DJPK) of the Ministry of Finance. The research uses path analysis technique with the results of DAU has a significant positive effect on education function expenditure, DBH has no effect on education function expenditure, DAU has a significant negative effect on HDI, DBH has a significant positive effect on HDI, education function expenditure has no effect on HDI, DAU has no effect on HDI through education function expenditure, and DBH has no effect on HDI through education function expenditure.
The Effect of Training on Access Employment of Pre-Employment Card Participants
Authors: Awinda Siti Nur Arliya , Syafitri Wildan
Published: January 2025

This study aims to determine the effect of pre-employment card training at the Cybers Academy Institute in increasing a person's chances of getting access to employment. By using primary data, namely online surveys given to alumni of Cybers Academy training participants. The results of logistic regression analysis show that participants who take training at Cybers Academy have a greater tendency to get access to employment. Furthermore, in the age group, age 26 years and over has an influence on job access. Participants who have previous work experience and attended training at Cybers Academy have a greater chance of gaining access to employment. Meanwhile, participants who live in the city and attend training have a greater chance of finding job access.
 
Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan kartu pra kerja di Cybers Academy Institute dalam meningkatkan peluang seseorang mendapatkan akses pekerjaan. Dengan menggunakan data primer yaitu survei online yang diberikan kepada alumni peserta pelatihan Cybers Academy. Hasil analisis regresi logistik menunjukkan bahwa peserta yang mengikuti pelatihan di Cybers Academy memiliki kecenderungan lebih besar untuk mendapatkan akses pekerjaan. Selanjutnya pada kelompok umur, umur 26 tahun ke atas mempunyai pengaruh terhadap akses kerja. Peserta yang memiliki pengalaman kerja sebelumnya dan mengikuti pelatihan di Cybers Academy memiliki peluang lebih besar untuk mendapatkan akses pekerjaan. Sedangkan peserta yang berdomisili di kota dan mengikuti pelatihan mempunyai peluang lebih besar untuk mendapatkan akses pekerjaan.
Analysis of the Effect of Capital Expenditure, Regional Investment, Labor Absorption, and Economic Growth on Poverty
Authors: Novitasari Riska , Susilo
Published: January 2025

The reduction in poverty and the high gap between the target and the actual poverty percentage are followed by an increase in capital expenditure, a drastic increase in regional investment in 2022 will not reduce poverty drastically, labor absorption will increase drastically by 3.1%, and economic growth is ranked 3rd. throughout the island of Java. So this research aims to determine the influence of Capital Expenditures, Regional Investment, Labor Absorption, and Economic Growth on Poverty in Central Java Province in 2017-2022. The samples used in this research were 35 regencies/cities in the province of Central Java in the period 2017 to 2022. Data analysis used in this research was multiple linear regression using the T-Test, F Test, and Coefficient of Determination (R2) . The research results show that capital expenditure has a significant positive effect on poverty, regional investment has an insignificant negative effect on poverty, labor absorption has an insignificant negative effect on poverty, and economic growth has a significant negative effect on poverty.
Analysis of Public Wellbeing as the Determinants of Income Distribution Disparity in North Sumatra in the 2002-2021 Period
Authors: Saing Rhenata Novita
Published: January 2025

Income distribution disparity is one of the challenges in the economic development process in any Indonesian region, especially North Sumatra. The objective of this research is to analyze how public wellbeing serves as one of the determining factors for income distribution disparity in North Sumatra during the 2002-2021 period. This quantitative study uses the Two-Stage Least Squares (2SLS), whose result suggest that population and poverty do not significantly influence per capita GRDP and that Human Development Index (HDI) positively and significantly influences per capita GRDP. Further, public wellbeing, which was measured using per capita GRDP, positively and significantly affects income distribution disparity, confirming Kuznets’s inversed U hypothesis. The findings above imply the importance of government policies aimed at enhancing human resource quality through education and health and designing more effective poverty eradication programs to attain sustainable equitable economic development in North Sumatra.
Assessing The Effects of GDP and FDI Inflows on Carbon Dioxide Emission
Authors: Sazuli Anindita Virgia Fanny
Published: January 2025

Indonesia is one of the world's largest emitters of carbon dioxide. This aligns with the Environmental Kuznets Curve (EKC) hypothesis, which states that economic growth initially causes environmental damage. This study uses the Error Correction Model (ECM) with time series data from 2002-2022 to definitively examine the relationship between sectoral GDP and FDI inflows with CO2 emissions in Indonesia. The results show that sectoral GDP significantly negatively affects CO2 emissions in the long and short run. In contrast, the quadratic form of GDP has a positive effect, indicating an anomaly in the expected EKC pattern. Moreover, FDI inflows significantly affect CO2 emissions only in the long run. These findings highlight the urgent need for policymakers to implement environmentally sustainable economic development strategies in Indonesia.
 
Abstrak
Indonesia merupakan salah satu penghasil emisi karbon dioksida terbesar di dunia. Hal ini sejalan dengan hipotesis Environmental Kuznets Curve (EKC) di mana pertumbuhan ekonomi pada awalnya akan menyebabkan kerusakan lingkungan. Penelitian ini menggunakan Error Correction Model (ECM) dengan periode data dari tahun 2002-2022 untuk menguji secara definitif hubungan antara PDB sektoral dan FDI Inflows dengan emisi CO2 di Indonesia. Hasil penelitian menunjukkan bahwa PDB sektoral memiliki pengaruh negatif yang signifikan terhadap emisi CO2, baik di jangka panjang maupun jangka pendek. Sebaliknya, bentuk kuadrat dari PDB memiliki efek positif, yang mengindikasikan adanya anomali dalam pola EKC. Selain itu, FDI Inflows memiliki pengaruh yang signifikan terhadap emisi CO2 hanya dalam jangka panjang. Temuan-temuan ini menyoroti adanya kebutuhan mendesak bagi para pembuat kebijakan untuk menerapkan strategi pembangunan ekonomi yang ramah lingkungan di Indonesia.
Analysis of Different Noise Reduction Effects of Ground Penetrating Radar Image of Cavity Behind Tunnel Primary Support Based on Singular Value Decomposition and Wavelet Transform
Authors: Zhou Chao
Published: January 2025

The cavity behind the lining structure is a typical disease in tunnel engineering. Cavity seriously affects the interaction
between lining and surrounding rock, resulting in uneven bearing of lining structure and stress concentration, which can easily
induce lining concrete cracking, water leakage and other diseases. Accurate identification of lining structure cavities is the key
to ensure the normal operation of the tunnel. However, the ground penetrating radar detection images of lining cavities often
contain interference signals such as background noise, which seriously affects the accuracy and clarity of cavity detection. The
application effects of wavelet transform and singular value decomposition in image denoising and resolution of tunnel lining
cavity ground penetrating radar are studied. Under this background, the model test of regular and irregular cavity detection
behind tunnel lining is carried out, in which the irregular cavity is located in the surrounding rock environment of filling soil to
simulate the real situation of tunnel. The measured images of lining cavity under different working conditions are obtained, and
the image denoising analysis is carried out. The results show that singular value decomposition can effectively suppress noise.
The ground penetrating radar image after singular value decomposition denoising is clearer, and the image resolution is
effectively improved, thus realizing the accurate identification of cavity diseases behind the primary support of the tunnel
El aprendizaje colaborativo en los procesos de lectura y escritura desde la virtualidad, para estudiantes con discapacidad intelectual
Authors: Pérez Barragán Dirley Yurani , Ariza Díaz Mary Luz
Published: January 2025

El objetivo principal de este proyecto investigativo fue fortalecer los procesos de lectura y escritura en estudiantes con condición de discapacidad intelectual de básica secundaria y media, a través de la implementación de una propuesta basada en el aprendizaje colaborativo, desde la virtualidad. Esta investigación se efectuó bajo un enfoque cualitativo de tipo descriptivo, en el cual se busca especificar las características pedagógicas, personales y familiares que influyen en el rendimiento académico de estos estudiantes. Así mismo, se tuvo en cuenta un diseño de investigación-acción con el propósito de comprender y dar herramientas propicias para minimizar la problemática de los estudiantes seleccionados, frente a sus procesos de lectura y escritura. Como estrategia de investigación se realizó una entrevista semiestructurada a los docentes de las diferentes asignaturas, un test de acompañamiento a las familias, una valoración pedagógica a cada uno de los estudiantes y una entrevista estructurada a 5 docentes y 5 estudiantes. Para el muestreo, se tuvo en cuenta un grupo focal de 14 jóvenes pertenecientes a los niveles de básica y media con discapacidad intelectual, al igual que sus familias y los docentes de estos grados. En el análisis realizado, se logró identificar, como factores determinantes, la poca participación de la familias en los procesos escolares de los estudiantes y las limitaciones que esto genera en su aprendizaje; así mismo, se destaca la importancia de establecer estrategias y metodologías para la flexibilización curricular, que reconozcan la diversidad de los jóvenes, sus habilidades y capacidades, generando dinámicas de fácil acceso y comprensión, a través del uso de las herramientas y plataformas tecnológicas.