bluuebunny/crossref_metadata_2025 huggingface dataset:
A nomogram to predict postoperative deep vein thrombosis in patients with femoral fracture: a retrospective study
Authors: Wu Linqin , Cheng Bo
Published: June 2023

Objective

The implementation of more active anticoagulant prevention and treatment measures has indeed led to a significant reduction in the incidence of perioperative deep vein thrombosis (DVT) among patients with bone trauma. However, it is important to note that despite these efforts, the incidence of DVT still remains relatively high. According to the Caprini score, all patients undergoing major orthopedic surgery were defined as the high-risk group for DVT. Stratifying the risk further within high-risk groups for DVT continues to present challenges. As a result, the commonly used Caprini score during the perioperative period is not applicable to orthopedic patients. We attempt to establish a specialized model to predict postoperative DVT risk in patients with femoral fracture.

Methods

We collected the clinical data of 513 patients undergoing femoral fracture surgery in our hospital from May 2018 to December 2019. According to the independent risk factors of DVT obtained by univariate and multivariate logistic regression analysis, the corresponding nomogram model was established and verified internally. The discriminative capacity of nomogram was evaluated by receiver operating characteristic (ROC) curve and area under the curve (AUC). The calibration curve used to verify model consistency was the fitted line between predicted and actual incidences. The clinical validity of the nomogram model was assessed using decision curve analysis (DCA) which could quantify the net benefit of different risk threshold probabilities. Bootstrap method was applied to the internal validation of the nomogram model. Furthermore, a comparison was made between the Caprini score and the developed nomogram model.

Results

The Caprini scores of subjects ranged from 5 to 17 points. The incidence of DVT was not positively correlated with the Caprini score. The predictors of the nomogram model included 10 risk factors such as age, hypoalbuminemia, multiple trauma, perioperative red blood cell infusion, etc. Compared with the Caprini scale (AUC = 0.571, 95% CI 0.479–0.623), the calibration accuracy and identification ability of nomogram were higher (AUC = 0.865,95% CI 0.780–0.935). The decision curve analysis (DCA) indicated the clinical effectiveness of nomogram was higher than the Caprini score.

Conclusions

The nomogram was established to effectively predict postoperative DVT in patients with femoral fracture. To further reduce the incidence, more specialized risk assessment models for DVT should take into account the unique risk factors and characteristics associated with specific patient populations.
Post-prandial analysis of fluctuations in the platelet count and platelet function in patients with the familial chylomicronemia syndrome
Authors: Larouche Miriam , Brisson Diane , Morissette Marie-Claude , Gaudet Daniel
Published: June 2023

Background

The familial chylomicronemia syndrome (FCS) is an ultra rare disease caused by lipoprotein lipase (LPL) deficiency associated with potentially lethal acute pancreatitis risk. Thrombocytopenia (platelet count < 150,000 × 109/L) has been reported in patients with FCS, treated or not with volanesorsen, a second generation APOC3 anti-sense oligonucleotide. Chylomicrons are the lipoproteins delivering fat after a meal and FCS thus has a post-prandial origin. Platelet count and function have not been studied post-prandially in FCS.

Objective

To evaluate post-prandial fluctuations in the platelet count (PLC) and functional defects of hemostasis in FCS.

Methods

PLC, functional defects in hemostasis and hematologic variables were measured up-to 5 h after a meal in 6 homozygotes for FCS causing gene variants (HoLPL), 6 heterozygotes for LPL loss-of-function variants (HeLPL) and 7 normolipidemic controls.

Results

Hourly post-prandial PLC was significantly lower in HoLPL than in controls (P < 0.009). Compared to the other groups, the PLC tended to decrease rapidly (in the first hour) post-meal in HoLPL (P = 0.03) and remained lower than baseline 5-h post-meal (P = 0.02) whereas it tended to slightly increase in normolipidemic controls (P = 0.02). Platelet function was not affected by the prandial status. In HoLPL, post-prandial fluctuations in the PLC positively correlated with the lymphocyte count (P = 0.005) and negatively with neutrophil/lymphocyte ratio (NLR).

Conclusion

The PLC decreases post-prandially in FCS (HoLPL), is not associated with changes in functional defects of hemostasis and correlates with the NLR, a marker of acute pancreatitis severity.
Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer
Authors: Katzenellenbogen Benita S. , Guillen Valeria Sanabria , Katzenellenbogen John A.
Published: June 2023

FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and cancer growth and progression. It is expressed in all subtypes of breast cancer and is the factor most associated with risk of poor patient survival, especially so in triple negative breast cancer (TNBC). Thus, new approaches to inhibiting FOXM1 and its activities, and combination therapies utilizing FOXM1 inhibitors in conjunction with known cancer drugs that work together synergistically, could improve cancer treatment outcomes. Targeting FOXM1 might prove especially beneficial in TNBC where few targeted therapies currently exist, and also in suppressing recurrent advanced estrogen receptor (ER)-positive and HER2-positive breast cancers for which treatments with ER or HER2 targeted therapies that were effective initially are no longer beneficial. We present these perspectives and future directions in the context of what is known about FOXM1, its regulation, and its key roles in promoting cancer aggressiveness and metastasis, while being absent or very low in most normal non-regenerating adult tissues. We discuss new inhibitors of FOXM1 and highlight FOXM1 as an attractive target for controlling drug-resistant and difficult-to-suppress breast cancers, and how blocking FOXM1 might improve outcomes for patients with all subtypes of breast cancer.
SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen
Authors: Arias Lilibeth , Otwombe Kennedy , Waja Ziyaad , Tukvadze Nestani , Korinteli Tamta , Moloantoa Tumelo , Fonseca Kaori L , Pillay Natasha , Seiphetlo Thabiso , Ouchi-Vernet Dan , Siles Adrian , Carabias Lidia , Quiñones Carles , Vashakidze Sergo , Martinson Neil , Vilaplana Cristina
Published: June 2023

Background

The duration and regimen of tuberculosis (TB) treatment is currently based predominantly on whether the M. tuberculosis (Mtb) strain is drug-sensitive (DS) or multidrug-resistant (MDR) with doses adjusted by patients’ weight only. The systematic stratification of patients for personalized treatment does not exist for TB. As each TB case is different, individualized treatment regimens should be applied to obtain better outcomes. In this scenario, novel therapeutic approaches are urgently needed to (1) improve outcomes and (2) shorten treatment duration, and host-directed therapies (HDT) might be the best solution. Within HDT, repurposed drugs represent a shortcut in drug development and can be implemented at the short term. As hyperinflammation is associated with worse outcomes, HDT with an anti-inflammatory effect might improve outcomes by reducing tissue damage and thus the risk of permanent sequelae.

Methods

SMA-TB is a multicentre randomized, phase IIB, placebo-controlled, three-arm, double-blinded clinical trial (CT) that has been designed in the context of the EC-funded SMA-TB Project (www.smatb.eu) in which we propose to use 2 common non-steroidal anti-inflammatory drugs (NSAID), acetylsalicylic acid (ASA) and ibuprofen (Ibu), as an HDT for use as adjunct therapy added to, and compared with, the standard of care (SoC) World Health Organization (WHO)-recommended TB regimen in TB patients. A total of 354 South African and Georgian adults diagnosed with confirmed pulmonary TB will be randomized into SoC TB treatment + placebo, SoC + acetylsalicylic acid or SoC + ibuprofen.

Discussion

SMA-TB will provide proof of concept of the HDT as a co-adjuvant treatment and identify the suitability of the intervention for different population groups (different epidemiological settings and drug susceptibility) in the reduction of tissue damage and risk of bad outcomes for TB patients. This regimen potentially will be more effective and targeted: organ saving, reducing tissue damage and thereby decreasing the length of treatment and sequelae, increasing cure rates and pathogen clearance and decreasing transmission rates. It will result in better clinical practice, care management and increased well-being of TB patients.

Trial registration

Clinicaltrials.gov NCT04575519. Registered on October 5, 2020.
Reading intervention for students with intellectual disabilities without functional speech who require augmentative and alternative communication: a multiple single-case design with four randomized baselines
Authors: Ulriksen Line Britt , Bilet-Mossige Marthe , Moreira Hugo Cogo , Larsen Kenneth , Nordahl-Hansen Anders
Published: June 2023

Background

Literacy is one of the most important skills a students can achieve, as it provides access to information and communication. Unfortunately, literacy skills are not easily acquired, especially for students with intellectual disabilities who require augmentative and alternative communication (AAC). There are many barriers to literacy acquisition, some due to low expectations from parents and teachers and lack of evidence-based reading programs and reading materials adapted for AAC. Barriers as a result of extensive support needs is also a real factor. This trial aims to deliver reading instructions to 40 students with intellectual disabilities who require AAC and contribute in the debate on how to best support this population through reading instructions to maximizes their reading skills.

Methodology

Forty non-verbal or minimally verbal students (age 6–14) with intellectual disabilities who require AAC will be part of a reading intervention with a multiple single-case design with four randomized baselines. The intervention period will last for 18 months and will commence in March 2023. The students will receive the intervention in a one-to-one format, working systematically with a reading material that contains phonological awareness and decoding tasks based on the Accessible Literacy Learning (ALL) developed by Janice Light and David McNaughton. All the teachers will be trained to deliver the reading intervention.

Discussion

The reading material “Lesing for alle” (Reading for all) is based on and follow the strategies behind the research of ALL. The current trial will through a reading intervention contribute to move beyond only teaching sight words and combine several reading components such as sound blending, letter-sound correspondence, phoneme segmentation, shared reading, recognition of sight words, and decoding. The strategies and methods in use is built on the existing science of reading, especially what has been effective in teaching reading for students with intellectual disabilities who require AAC. There is limited generalizability of prior findings in reading-related phonological processing interventions to different populations of them who use AAC specially outside of the USA. More research is needed to understand how programs designed to improve reading skills across other settings understand the program’s long-term effects and to study the effectiveness when delivered by educators who are not speech language therapists or researchers.

Trial registration

NCT05709405. Registered 23 January 2023.
Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis
Authors: Bocova Ledio , Hubens Wouter , Engel Cordula , Koschmieder Steffen , Jost Edgar , Wagner Wolfgang
Published: June 2023

Hematopoietic stem and progenitor cells (HSPCs) are quantified in daily clinical practice by flow cytometry. In this study, we provide proof of concept that HSPCs can also be estimated by targeted DNA methylation (DNAm) analysis. The DNAm levels at three individual CG dinucleotides (CpG sites) in the genes MYO1D, STK17A, and SP140 correlated with CD34+ cell numbers in mobilized peripheral blood and with blast counts in leukemia. In the future, such epigenetic biomarkers can support the evaluation of stem cell mobilization, HSPC harvesting, or blast count in leukemia.
Plasma activated Ezhangfeng Cuji as innovative antifungal agent and its inactivation mechanism
Authors: Lin Lin , Zhuo Yue , Dong Qiran , Yang Chunjun , Cheng Cheng , Liu Taofeng
Published: June 2023

Candida albicans is a highly drug-resistant fungus for which new treatments are urgently needed due to the lack of clinically effective options. In this study, we evaluated the antifungal activity and mechanism of plasma-activated Ezhangfeng Cuji (PAEC) against Candida albicans and compared it with physiological saline (PS), plasma-activated physiological saline (PAPS) and Ezhangfeng Cuji (EC). After dielectric barrier discharge (DBD) plasma treatment with EC for 20 min followed by a 10 min immersion of Candida albicans, the fungus was reduced by approximately 3 orders of magnitude. High performance liquid chromatography (HPLC) results showed an increase of 41.18% and 129.88% in the concentration of oxymatrine and rhein, respectively, after plasma-treated EC. The concentrations of reactive species (RS), such as H2O2, $${\text{NO}}_{3}^{ - }$$

NO

3

-

, and O3, were found to be higher and the pH value was getting lower in PS after plasma treatment. Detailed analysis of intracellular material leakage, reactive oxygen species (ROS), apoptosis for Candida albicans and observation by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) demonstrated that PAPS, EC and PAEC disrupt the morphological structure of Candida albicans to varying degrees.Additionally, specific analyses on Candida albicans virulence factors, such as adhesion to tissue surfaces, cell surface hydrophobicity (CSH), the transition of yeast-phase cells to mycelium-phase cells, and the secretion of hydrolytic enzymes for Candida albicans were conducted and found to be inhibited after PAPS/EC/PAEC treatment. In our investigation, the inhibitory effects on Candida albicans were ranked from strong to weak as follows: PAEC, EC, PAPS, and PS.
Integration of Genetic Testing and Counseling in Patients With Breast Cancer in a Large, Multisite Community-Based Practice
Authors: Mendenhall Molly A. , Guinigundo Andrew , Davies Dan , Ward Patrick , Drosick David R. , Waterhouse David M.
Published: June 2023

PURPOSE

Despite data-driven consensus recommendations, there remains significant nonadherence to genetic screening and testing. More than 300,000 patients are diagnosed with breast cancer annually, with one third of these estimated to be eligible for homologous recombination deficiency (HRD)/BRCA testing following National Comprehensive Cancer Network (NCCN) guidelines. Only 35% of eligible patients are referred for genetic counseling.

METHODS

The goal of this project was to apply NCCN guidelines for germline genetic testing to all new patients with breast cancer within a large community oncology practice to improve HRD/BRCA testing. Plan-Do-Study-Act methodology was used, and cycles were built on a proven teaching infrastructure. In cycle 1, providers were educated and directed to use electronic health record (EHR) templates in the setting of an initial diagnosis visit and treatment planning. Discreet data fields were created in the EHR during cycle 2 to streamline and automate the process. Appropriate patients were referred to the genetics team for further evaluation, counseling, and testing. Adherence to the plan was maintained and measured using data analytic reports and chart audits.

RESULTS

Of the 1,203 patients with breast cancer eligible for inclusion, 1,200 (99%) were screened according to NCCN guidelines. Of the screened patients, 631 (52.5%) met the referral/testing criteria. In total, 585 (92.7%) of the 631 were referred to a genetic specialist. Seven percent had previous referrals. A total of 449 (71%) patients were acceptable to genetics referral while 136 (21.5%) patients refused.

CONCLUSION

The implemented methods of education, NCCN guidelines imbedded within provider notes, and discreet data fields in the EHR have proven to be highly effective in screening appropriate patients and ordering subsequent genetic referrals.
Dose-dependent Association of Alcohol Consumption With Obesity and Type 2 Diabetes: Mendelian Randomization Analyses
Authors: Lu Tianyuan , Nakanishi Tomoko , Yoshiji Satoshi , Butler-Laporte Guillaume , Greenwood Celia M T , Richards J Brent
Published: June 2023

Context

Effects of modest alcohol consumption remain controversial. Mendelian randomization (MR) can help to mitigate biases due to confounding and reverse causation in observational studies, and evaluate the potential causal role of alcohol consumption.

Objective

This work aimed to evaluate dose-dependent effect of alcohol consumption on obesity and type 2 diabetes.

Methods

Assessing 408 540 participants of European ancestry in the UK Biobank, we first tested the association between self-reported alcohol intake frequency and 10 anthropometric measurements, obesity, and type 2 diabetes. We then conducted MR analyses both in the overall population and in subpopulations stratified by alcohol intake frequency.

Results

Among individuals having more than 14 drinks per week, a 1-drink-per-week increase in genetically predicted alcohol intake frequency was associated with a 0.36-kg increase in fat mass (SD = 0.03 kg), a 1.08-fold increased odds of obesity (95% CI, 1.06-1.10), and a 1.10-fold increased odds of type 2 diabetes (95% CI, 1.06-1.13). These associations were stronger in women than in men. Furthermore, no evidence was found supporting the association between genetically increased alcohol intake frequency and improved health outcomes among individuals having 7 or fewer drinks per week, as MR estimates largely overlapped with the null. These results withstood multiple sensitivity analyses assessing the validity of MR assumptions.

Conclusion

As opposed to observational associations, MR results suggest there may not be protective effects of modest alcohol consumption on obesity traits and type 2 diabetes. Heavy alcohol consumption could lead to increased measures of obesity as well as increased risk of type 2 diabetes.
Transitions in development – an interview with Evgeny Kvon
Authors: Eve Alex
Published: June 2023

Evgeny Kvon is an Assistant Professor at the University of California, Irvine (UCI) in the Department of Developmental and Cell Biology, USA. His lab studies non-coding regulatory DNA and its mechanistic role in the control of gene expression to understand more about development, disease and evolution. Last year, Evgeny received the National Institutes of Health Director's New Innovator Award. We spoke to Evgeny over Zoom to learn more about his career and the silver lining to starting a lab during the COVID-19 lockdowns.
Working Paper 43: How corruption threatens the forests of Ukraine
Authors: Hrynyk Yehor , Biletskyi Andrii , Cabrejo le Roux Amanda
Published: June 2023

This report offers a detailed deep dive into how corruption fuelled illegal logging in Ukraine during the period before the full-scale war. It explains how the Russian invasion has raised the risks of illegal logging, by increasing demand for wood and its relative value as a resource, and by reducing inspections and civil society oversight.

Building on pre-war case studies, selected interviews and a review process with various stakeholders, the report outlines the widespread corruption challenges in Ukraine's forestry sector and proposes relevant interventions in the war and reconstruction contexts. 

The report identifies specific corruption patterns linked to three main types of illegal logging:

By private actors such as communities and criminal groups, who can evade justice by corrupting law enforcement officials.

By forest management officials, who sometimes obtain false paperwork to fell trees – thus easing their export abroad.

Following the illegal appropriation of forests through manipulation of land documents. 

A significant proportion of wood illegally logged in Ukraine comes with (illegally obtained) permits, so can be "legally" exported to foreign markets in the European Union and elsewhere.

Both governments and the private sector in countries that import wood and/or support Ukraine's reconstruction efforts have a role to play in preventing the illegal destruction of Ukraine's forests.
Industrial safety. Workshop
Authors: Svetlana Alekseevna
Published: June 2023

The textbook discusses the main issues of organizing and conducting practical work on the discipline "Industrial safety". Practical work is presented in the field of ensuring human safety in the industrial environment by identifying and assessing hazards, using protective equipment against them and organizing the safety of activities to reduce the risk of occupational injuries and occupational morbidity; practical work in the field of ensuring the safe operation of lifting mechanisms, construction machinery, fire safety.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of technical universities studying in the direction of "Technosphere safety", as well as students of technical specialties studying the discipline "Life safety". It may be useful for practical workers of labor protection and industrial safety services.
Value attitude to the family as the basis of the spiritual and moral formation of the individual
Authors: Serebryakova Tat'yana , Koneva Irina
Published: June 2023

The monograph is devoted to one of the most important and global problems of our time — the problem of the value culture of the individual. At the same time, the authors focus on studying the level of development of spirituality and morality of preschool children, on the one hand, as a significant component of personality, on the other hand, as the most important condition for educating them on the foundations of a value attitude to the world.
The authors, in the historiographical aspect of the presentation, present the positions of various scientists regarding the essential features of the phenomenon of "value culture of personality", establish the relationship between the concepts of "values" and "value culture" of personality, consider the psychological patterns of the development of value culture, as well as the phenomena of "spirituality" and "morality" at the stage of preschool childhood.
It is intended for teachers and teachers-psychologists of preschool educational organizations, as well as students, undergraduates and teachers of pedagogical universities and colleges.
Redundancy management of technical systems. A supervisory way to manage configurations
Authors: Bukov Valentin , Ageev Andrey , Evgenov Aleksandr , Shurman Vladimir
Published: June 2023

The monograph is devoted to the issue of redundancy management of technical systems in the interests of giving them the properties of survivability, fault tolerance, fault safety, adaptation to changing operating conditions and rational use of available resources. Attention is focused on the supervisory approach to the redundancy management of technical systems based on specially introduced software and logic structures — configuration supervisors. Ideas and solutions on the information structure and control algorithms for reconfiguring avionics complexes with redundancy of heterogeneous non-universal components are systematically presented.
Designed for students and postgraduates of technical universities, as well as researchers and designers specializing in the development, research and testing of reconfigurable technical systems.
Non-surgical treatments for androgenetic alopecia: a literature review
Authors: Woźniak Aleksander , Kozłowska Martyna , Sydor Patryk , Wartacz Marcel , Kreft Rafał , Hunek Adrian Krzysztof , Bigdoń Anna Maria , Ćwiek Maciej , Gorczyca Przemysław , Góra Mateusz
Published: June 2023

Androgenetic alopecia is the most common type of hair loss and affects at least 80% of men and half of women before the age of 70, with the incidence increasing with age. Androgenetic alopecia is an ailment conditioned by genetic and hormonal factors, associated with excessive stimulation of the androgen receptor in the cells of the hair follicle. With the development of medicine, more and more therapeutic methods for androgenetic alopecia appear on the market, including minoxidil, 5-α-reductase inhibitors, microneedling, platelet-rich plasma, low-energy laser therapy, rosemary oil, or siRNA. Thanks to the constantly growing amount of scientific research, progressively more is known about the mechanisms of androgenetic alopecia development and potential strategies to stop it. The article analyzes the literature using electronic databases and textbooks to compile methods that can be an effective alternative for people who do not want to undergo surgery. Some of the methods presented in the article have the potential to not only slow down, but also reverse the progression of the disease. However, each of them still has its limitations.
Treatment of small intestinal bacterial overgrowth: Conventional antibiotic therapy and alternative therapy - probiotics and low FODMAP diet
Authors: Litwiniuk Maria , Zaniuk Marcin , Hurkała Kamil , Antonik Dominika , Denys Barbara , Góra Karolina , Zdziennicki Wojciech , Zimnicki Patryk , Lato Marta , Iberszer Konrad
Published: June 2023

Introduction and purpose of the study: Small intestinal bacterial overgrowth syndrome (SIBO) is a syndrome characterized by an increased number of bacteria in the small intestine. The condition causes many non-specific symptoms such as diarrhea, abdominal pain and bloating. The purpose of this study is to review the current knowledge regarding treatment options for SIBO.                                           

Methodology: A literature review was conducted based on PubMed, GoogleScholar databases and American College of Gastroenterology (ACG) guidelines.

Current knowledge: SIBO is a heterogeneous syndrome. Symptoms of bacterial overgrowth include bloating, abdominal pain and abnormal bowel motility. In more severe cases, patients may experience malabsorption leading to weight loss and malnutrition. SIBO can occur in healthy individuals, but very often accompanies other conditions. The primary test for diagnosis is non-invasive lactulose or glucose breath tests. For treatment, the antibiotic rifaximin is preferred. It exhibits a broad spectrum of activity and a low toxicity profile. Treatment may also include diet therapy and the use of probiotics.

Summary: SIBO continues to be both a diagnostic and therapeutic problem. Effective treatment includes not only elimination of the bacteria but also treatment of predisposing conditions. Conclusions of the study show a positive effect of rifaximin on the reduction of SIBO symptoms and improvement of patients' quality of life. The use of certain probiotics has a proven effect. According to the currently available literature, the effectiveness of the low-FODMAP diet in SIBO is hypothetical and further studies are needed to unequivocally confirm its efficacy.
Critical Kirchhoff-type equation with singular potential
Authors: Su Yu , Liu Senli
Published: June 2023

In this paper, we deal with the following Kirchhoff-type equation:
\begin{equation*}
-\bigg(1
+\int_{\mathbb{R}^{3}}|\nabla u|^{2}dx\bigg)
\Delta u
+\frac{A}{|x|^{\alpha}}u
=f(u),\quad x\in\mathbb{R}^{3},
\end{equation*}
where $A> 0$ is a real parameter and $\alpha\in(0,1)\cup ({4}/{3},2)$.
Remark that $f(u)=|u|^{2_{\alpha}^{*}-2}u +\lambda|u|^{q-2}u
+|u|^{4}u$,
where $\lambda> 0$, $q\in(2_{\alpha}^{*},6)$,
$2_{\alpha}^{*}=2+{4\alpha}/({4-\alpha})$
is the embedding bottom index, and $6$ is the embedding top index and Sobolev critical exponent.
We point out that the nonlinearity $f$ is the almost ``optimal'' choice.
First, for $\alpha\in({4}/{3},2)$, applying the generalized version of Lions-type
theorem and the Nehari manifold, we show the existence of nonnegative
Nehari-type ground sate solution for above equation. Second, for $\alpha\in(0,1)$,
using the generalized version of Lions-type theorem and the Poho\v{z}aev
manifold, we establish the existence of nonnegative Poho\v{z}aev-type ground
state solution for above equation. Based on our new generalized version
of Lions-type theorem, our works extend the results in Li-Su [Z. Angew. Math. Phys. {\bf 66} (2015)].
«Es riquísima la cantera de la creación». Textos y contextos del trabajo de Carmen Conde en los medios audiovisuales: cine, radio, televisión.
Authors: Broullon-Lozano Manuel A.
Published: June 2023

En la vocación poética de Carmen Conde, los medios de comunicación desempeñaron un papel crucial para a su consolidación como una voz de primer orden en la esfera pública. En este trabajo acotaremos el objeto de estudio sobre la actividad de la escritora en los medios audiovisuales: cine, radio y televisión. Nuestros objetivos serán: 1) adquirir una perspectiva global de su trabajo en los medios y 2) su argumentación razonada, metodológica y contextualmente.
Kajian Proporsi Air Kelapa-Sari Daun Kelor (Moringa oleifera) dan Konjac Powder Terhadap Kualitas Fisikokimia dan Sensoris Jelly Drink Kelor
Authors: Adi Seno Mawarno Binardo , Bianca Lewerissa Karina
Published: June 2023

Masalah stunting (kerdil) telah menjadi persoalan global termasuk di negara Indonesia. Perlunya pemenuhan zat gizi baik gizi makro maupun mikro di fase awal pertumbuhan akan mengurangi risiko terjadinya stunting pada anak. Daun kelor merupakan salah satu komoditas pangan kaya gizi berupa protein, serat, serta berbagai vitamin dan mineral seperti vitamin C, betakaroten, zat besi, dan kalsium. Penelitian ini bertujuan untuk mendapatkan inovasi pangan tinggi zat gizi untuk anak dalam bentuk jelly drink. Metode penelitian eksperimental menggunakan Rancangan Acak Lengkap dua faktorial untuk formulasi jelly drink yaitu rasio air kelapa dan sari daun kelor sebanyak 1:1 dan 1:2 dan konsentrasi konjac powder sebanyak 0,1 %, 0,2% dan 0,3%. Berdasarkan analisis kualitas secara fisik,  jelly drink dengan rasio 1:1 dan konsentrasi konjac powder 0,3% memiliki nilai sineresis yang paling baik. Sedangkan secara sensoris, jelly drink dengan perlakuan rasio 1:2 memiliki tingkat penerimaan yang lebih baik secara warna dan penerimaan secara keseluruhan (overall). Berdasarkan total nilai skor keseluruhan parameter fisik dan sensoris, jelly drink dengan proporsi air kelapa: sari daun kelor 1:1 dan konsentrasi konjac powder 0,2% merupakan perlakuan terbaik. Hasil analisis kimia menunjukkan jelly drink daun kelor terbaik memiliki kandungan protein sebesar 2,06% dan vitamin C sebesar 0,77%
AVALIAÇÃO DE DESEMPENHO EM CUSTOS DE TROCA: UMA REVISÃO DE LITERATURA
Authors: Tramontin Castanha Eduardo , Mannes Silvana , Murilo Petri Sergio
Published: June 2023

Estudos que investigam a avaliação de desempenho e os relacionamentos interorganizacionais têm enfatizado os custos de troca como forma de prever e compreender a retenção de clientes. Nesse sentido, este estudo objetivou conhecer e examinar as características das pesquisas científicas que abordam um fragmento da literatura referente à temática avaliação de desempenho em custos de troca. A pesquisa de abordagem qualitativa, utilizou o instrumento de intervenção construtivista ProKnow-C para a seleção e análise de portfólio bibliográfico. Os resultados evidenciam a necessidade de novas taxonomias para avaliar os custos de troca por meio de um instrumento que contenha um número menor de assertivas, uma vez que os apresentados pelos principais autores da área apresentam excesso de assertivas, o que pode limitar as respostas obtidas durante as investigações realizadas. Tal instrumento deve não somente incluir as principais categorias de custos de troca reconhecidas pela literatura (processual, financeira e relacional) mas, agregar perspectivas diversas evidenciadas por outros estudos. Conclui-se que a temática é considerada emergente, sendo investigada por pesquisadores de nacionalidades diversas, interessados no campo da avaliação de desempenho.
Editorial
Authors: Giraldi Janaina De Moura Engracia
Published: June 2023

Editorial
TRANSPARÊNCIA PÚBLICA: UMA INVESTIGAÇÃO SOBRE A DIVULGAÇÃO DOS GASTOS NO COMBATE À PANDEMIA DO CORONAVÍRUS NO MUNICÍPIO DE MARINGÁ
Authors: Ribeiro Roberto Rivelino Martins , Moura Cássia Marini , Mattiello Kerla , Pavão Juliane Andressa
Published: June 2023

Este estudo investigou a divulgação dos gastos realizados para o combate da pandemia a partir das informações disponibilizadas no portal da transparência do município. Elegeu-se como objeto de estudo os gastos realizados para combater o vírus, mediante a realização de um estudo que metodologicamente se apresenta como sendo de natureza aplicada, utilizando o método qualitativo e o quantitativo, com uso de técnicas bibliográficas, documentais e ex-post facto. Os resultados do estudo evidenciam redução da arrecadação municipal e seu reflexo consequente no valor dos gastos e investimentos realizados pelo município, contudo, tal fato não impactou nos valores, no exercício de 2020, destinados ao enfrentamento e combate da pandemia. Foi detectado também algumas falhas durante a elaboração de alguns documentos e relatórios, e sua publicação, já que se averiguou dados incompletos ou a descontinuidade da divulgação nos relatórios quadrimestrais, sobretudo nos recursos destinados ao auxílio alimentação e à assistência social.
OS ATRAVESSAMENTOS ENTRE A NECROPOLÍTICA E O PACTO NARCÍSICO DA BRANQUITUDE
Authors: Sievers Juliele Maria , Santos da Silva Érick
Published: June 2023

A partir da noção de “Necroplítica” trabalhada pelo filósofo camaronês Achille Mbembe e de “Pacto Narcísico da Branquitude” trabalhado pela psicóloga brasileira Cida Bento, este artigo tem como objetivo fomentar reflexões críticas sobre os atravessamentos desses dois conceitos. Pelo olhar de Achille Mbembe, Necroplítica é o poder exercido pelo soberano, no qual este usa uma política de aniquilamento e inimizade, decidindo quais corpos devem morrer e quais devem viver. Entendemos que tal perspectiva em grande medida se relaciona com o Pacto Narcísico da Branquitude que, de acordo com Cida Bento, atua de modo a colocar o sujeito branco como o ponto de referência em todas as esferas e estruturas sociais, perpetuando seus privilégios e tornando as demais raças e formas de existência inferiorizadas, inclusive política e socialmente. Nesse sentido, através dessa lógica necropolítica exercida pelo soberano somado a esse pacto narcísico da branquitude, são os corpos negros que devem, dentre os demais, morrer, pois são considerados o “Outro” – do sujeito branco – e o inimigo do Estado.
O COMUM, O PÚBLICO E O ESTADO
Authors: Martinez Óscar , Sombra Laurenio Leite
Published: June 2023

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O plano de parto como mecanismo de proteção do direito à autodeterminação da mulher em contexto obstétrico em Portugal
Authors: Macedo João Carlos , António Isa , Macedo Ermelinda , Lopes Maria de Fátima
Published: June 2023

A violência obstétrica constitui duas formas de violência contra a mulher, violando seus direitos humanos, como saúde, segurança, integridade física, integridade mental, respeito e, nos casos mais extremos, ou a própria vida . Abordaremos, as diversas tipologias, especialmente a violência física ocorrida fora do parto, através de insultos, falta de informação, desrespeito à autonomia e autodeterminação da mulher e violação do consentimento informado, livre e informado. Por outro lado, a prática de procedimentos médicos como episiotomia, excesso de medicação, privação de movimento, manobras como Kristeller, são potencializadores de risco para a saúde e a vida do próprio feto/infância. Portanto, afirmamos que a violência obstétrica não é apenas uma violência contra a mulher, mas também contra a criança. Revisamos, em termos bibliográficos, trabalhos e estudos na área do Direito, Bioética e Saúde Reprodutiva bem como, procedemos a uma exaustiva análise de diplomas legais internacionais e nacionais.
Concluímos que a violência exercida contra a mulher em contexto obstétrico é um ataque frontal às artes jurídicas da medicina e constitui uma forma de grave discriminação de gênero que merece censura legal por dois Estados e pelas classes médica e de enfermagem. Afirmamos, com justificação, que a episiotomia é atualmente qualificada como uma espécie de mutilação genital feminina, punível criminalmente. Por fim, defendemos que o acompanhamento direto do não parto e o cumprimento do plano de parto elaborado pela mulher ou domiciliar são mecanismos preventivos da violência obstétrica.
tênues limites entre o direito de viver e o direito de morrer: a perspectiva acadêmica, jurídica e bioética dos cuidados paliativos em animais de estimação
Authors: Carvalho Patricia Feiz Nardinelli Bernardes , FISCHER Marta
Published: June 2023

Os cuidados paliativos (CP) de animais estimados são um tema emergente na Medicina Veterinária, caracterizando-se como uma alternativa terapêutica à eutanásia precoce. O objetivo é mapear a perspectiva, critérios, procedimentos e referenciais éticos e científicos dos dois CPs e da eutanásia em animais estimados, testando as hipóteses de diferenças nas perspectivas da eutanásia e dos dois CPs, bem como entre os cenários nacional e internacional. Para isso, foi realizada uma revisão bibliográfica integrativa da produção científica e um recorte de análise jurisprudencial a respeito de duas reflexões legais sobre a atividade médica veterinária. A revisão integrativa resultou em 535 artigos, dois dos quais 43 atenderão aos critérios de inclusão, além de 800 comentários, dos quais 30% foram relativos a ações indenizatórias contra serviços veterinários e médicos. Os dados obtidos, com base no recorte proposto na pesquisa, permitirão caracterizar a abordagem científica do CP e da eutanásia, bem como lançar trilhas interpretativas de como os aspectos funcionais e as perspectivas de aplicação podem subsidiar as decisões da equipe médica veterinária e dois responsáveis ​​pelos cuidados com os animais. Em suma, para superar as limitações e consolidar as potencialidades dos dois CPs, é necessário um esforço multidimensional, incluindo as esferas normativa, técnica, social e ética. Vislumbra-se a aplicação da questão nas diretrizes de Bioética, sugerindo que seja realizada no espaço multidisciplinar da Comissão de Bioética do Hospital Veterinário, com o objetivo de auxiliar na deliberação de decisões conflitantes,
Monitoring and active stabilization of laser injection locking using beam ellipticity
Authors: Mishra Umang , Li Vyacheslav , Wald Sebastian , Agafonova Sofia , Diorico Fritz , Hosten Onur
Published: June 2023

We unveil a powerful method for the stabilization of laser injection locking based on sensing variations in the output beam ellipticity of an optically seeded laser. The effect arises due to an interference between the seeding beam and the injected laser output. We demonstrate the method for a commercial semiconductor laser without the need for any internal changes to the readily operational injection locked laser system that was used. The method can also be used to increase the mode-hop free tuning range of lasers, and has the potential to fill a void in the low-noise laser industry.
Graphene nanostrip transverse magnetic dual-channel refractive index sensor
Authors: Hossain Md. Mahbub , Talukder Muhammad Anisuzzaman
Published: June 2023

Generally, transverse magnetic (TM) polarization-based surface plasmons (SPs) are excited in plasmonic devices. While the transverse electric (TE) modes can be excited in graphene up to the visible frequency range, TM modes can be supported only from terahertz to the mid-infrared region. We show that graphene TM modes can be excited in the visible spectrum by applying a suitable voltage to the graphene layer and using an appropriate interfacing dielectric layer thickness. Furthermore, utilizing this TM mode, we propose a dual-channel refractive index sensor where the same analyte can be injected into the two channels for significantly sensitive detection of the analyte, or two different analytes can be injected into the two channels for their simultaneous detection. The proposed sensor exploits two graphene layers, one with nanostrip arrays, for efficient TM mode excitation. The nanostrips in the first graphene layer scatter the incoming radiation to the second, generating TM modes at both layers. The proposed dual-channel sensor shows 2530 degrees/RIU peak sensitivity when the sensing channels have the same analyte. The graphene nanostrips-based sensor will be a promising alternative to the traditional Kretschmann arrangement and significantly impact biosensing and refractive index sensing without needing noble metal in the structure.
Wastewater plumes can act as non-physical barriers for migrating silver eel
Authors: Winter Hendrik Volken , van Keeken Olvin Alior , Kleissen Frank , Foekema Edwin Matheus
Published: June 2023

Non-physical barriers for migrating fish, such as effluent plumes discharged by sewage treatment plants (WWTPs), are hardly considered, and field studies on this topic are very scarce. The encounter with these plumes however may evoke behavioural responses in fish and could delay or (partially) block the migration. In this study, the behavioural responses of 40 acoustically-tagged silver eel (Anguilla anguilla) were monitored in situ, when confronting a WWTP effluent plume during their downstream migration in the canal Eems, the Netherlands. Their behavioural responses and the potential blocking effect of the plume were assessed using a 2D and 3D telemetry design displayed in the waterway, and matched to a modelled and calibrated WWTP effluent plume. When confronted with the WWTP effluent plume during their downstream migration, 22 of the silver eels (59%) showed an avoidance response, varying from lateral diverting to multiple turning in the vicinity of the effluent plume. Nineteen out of these 22 (86%) eventually passed the study site. No silver eel showed attraction to the plume. Delays in migration were from several hours up to several days. Due to the strong variation in discharged volumes and flow velocity of the receiving canal, the WWTP plume did not always flow over the full width of the canal. As a result, numerous migratory windows, where silver eels could pass the WWTP while avoiding direct contact with the plume, remained available in time. When discharge points cannot be avoided, reduced or restricted to areas that are not preferred as fish migration routes, discharge points should be designed such, that the chance is limited that a waterway is (temporarily) impacted over its full width.
Effect of high-fat diet on the lipid profile of ovarian granulosa cells and female reproduction in mice
Authors: Gao Jinchun , Liu Mingchao , Liu Jingge , Shi Peihua , Cui Haoliang , Zhao Shunran , Zhang Xinbo , Tao Chenyu
Published: June 2023

Currently, comorbidities of obesity are becoming increasingly frequent. For example, obese women are more susceptible to reproductive diseases; however, the underlying mechanism remains poorly understood. The present study aimed to explore the effect of obesity on female reproduction and discuss changes of the lipid profile in ovarian granulosa cells. Fifty female mice were randomly divided into two groups, one group was fed high-fat diet, the other group was fed standard control diet, food and water freely. After 12 weeks of feeding, the average body weight of the high-fat diet mice (19.027g) was significantly higher than that of the standard control diet mice (36.877g) (P < 0.05). The tissue sections were stained with oil red O, and the online software mage Pro plus 6.0 analyzed the staining results, the lipids in the ovaries and endometria were found to be different between the two groups. Liquid chromatography-electrospray ionization with tandem mass spectrometry (LC-ESI-MS/MS) analysis of ovarian granulosa cells (GCs) was performed, with a total of 228 different lipids being identified, the abundant of 147 were increased and 81 were decreased in the high-fat diet group. Among them, PI (18:1/20:1) was the most different lipid, and high-fat feeding was 85 times higher than standard control group. Among these different lipids, 44% in phospholipid metabolism, 30% in glycerolipid metabolism, and 30% in fat digestion and absorption. The results of this study laid a theoretical foundation of the effects of diet-induced obesity on female reproduction.
Effects of iron supplementation on cognitive development in school-age children: Systematic review and meta-analysis
Authors: Gutema Befikadu Tariku , Sorrie Muluken Bekele , Megersa Nega Degefa , Yesera Gesila Endashaw , Yeshitila Yordanos Gizachew , Pauwels Nele S. , De Henauw Stefaan , Abbeddou Souheila
Published: June 2023

Background

Iron deficiency is negatively associated with children’s cognitive development. Evidence showed that iron supplementation improves cognitive development. Nearly 50% of anemia is caused by iron deficiency. Anemia affects more school-age children, at an age where their brain development continues. The aim of this systematic review and meta-analysis is to review the evidence from published randomized controlled trials to evaluate the effects of iron supplementation on cognitive development and function among school-age children.

Method

Five databases including MEDLINE, EMBASE, Scopus, Web of Science and CENTRAL were used to search for articles on April 20th, 2021. The search was reconducted on October 13th, 2022 to retrieve new records. Studies were eligible if they included school children 6–12 years of age, were randomized controlled trials, and if they tested iron supplementation and measured cognitive development.

Result

Thirteen articles were included in the systematic review. Overall, iron supplementation significantly improved intelligence (standardized mean difference, 95% confidence interval) (SMD 0.46, 95%CI: 0.19, 0.73, P<0.001), attention and concentration (SMD 0.44, 95%CI: 0.07, 0.81, P = 0.02) and memory (SMD 0.44, 95%CI: 0.21, 0.67, P <0.001) of school-age children. There was no significant effect of iron supplementation on school achievement of school-age children (SMD 0.06, 95%CI: -0.15, 0.26, P = 0.56). In a subgroup analysis, iron-supplemented children who were anemic at baseline had had better outcomes of intelligence (SMD 0.79, 95%CI: 0.41, 1.16, P = 0.001) and memory (SMD 0.47, 95%CI: 0.13, 0.81; P = 0.006).

Conclusion

Iron supplementation has a significant positive effect on the intelligence, attention and concentration, and the memory of school-age children but there was no evidence on the effect of iron supplementation on their school achievement.