bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges in the EU Banking Sector as Exemplified by Poland in View of Legislative Changes Related to Climate Crisis Prevention
Authors: Komarnicka Anna , Komarnicki Michał
Published: January 2022

The activity and initiatives undertaken by financial institutions to protect the environment are now the goal of the evolution of the entire financial market. However, it is important not to ignore the legal issues and their implications, which to a large extent now permeate many financial decisions and affect the practices and behaviours of banks. The main objective of this paper was to identify the current condition of and ongoing developments in European Union legal regulations concerning Environmental, Social, Governance (ESG) and sustainable finance. An important aspect of this study was also to analyse the tools, legal instruments, standards and guidelines of the European Commission and the European Banking Authority (EBA) and those proposed by the international business environment in the area of non-financial reporting ESG disclosures in the EU banking sector as exemplified by Poland. In addition, this paper analyses the status of implementation of ESG-related requirements set by the EU legal framework by banks, banking associations and associations of cooperative banks operating in Poland. To achieve the objectives of this study, and to answer the research questions posed, an analysis of primary and secondary sources was carried out in conjunction with a review of the (national and foreign) literature on the subject. Two non-reactive research methodologies were used in the design of this study: the doctrinal legal method and desk research. The results of the analysis indicate that EU regulations are at the drafting stage and those adopted so far require a number of amendments. Banker associations have voiced extensive criticism of the regulations, which are viewed by banks as inadequate, unclear and inconsistent. Both EU and Polish banker associations primarily point to a high degree of generality in the solutions and legal frameworks adopted. The legal acts enacted to date do not correspond to the needs of the market. The analysis of the positions of the banking associations also revealed that the EU legislation still has gaps preventing a harmonised approach to the comprehensive and consistent integration of ESG factors by banks in their strategy and operations.
Global Warming: Is It (Im)Possible to Stop It? The Systems Thinking Approach
Authors: Mella Piero
Published: January 2022

For some time, there has been a slow but gradual rise in the average temperature of the entire globe, a “global warming”, in fact, the result of human and natural processes that have been producing this phenomenon for decades. Since they are not directly perceived by individuals, these processes and their effects have been ignored for a long time, or at least not considered to be immediately harmful and dangerous. Global warming does not depend so much on solar radiation as it does on the greenhouse effect deriving from the continuous emission, by human activities and natural events, of greenhouse gases that accumulate in the atmosphere and form a barrier to the dispersion of heat produced by solar radiation. A good number of models exists to explain how global warming is produced, which are technical in nature and consider the production of greenhouse gases as the most important cause; however, they do not always analyze and justify the reasons for such emissions. Following the logic, language and methods of Senge’s systems thinking, the paper aims to present a general model, the GEAM—qualitative in nature, but rational and coherent—for highlighting the interacting factors that give rise to and maintain global warming. This model constitutes a reference framework to identify possible “strategic areas” within which to identify man-made “artificial” and “natural” factors that can control the phenomenon and to order the countless ideas and interventions that different nations carry out individually to control global warming. The model presented is qualitative in nature and does not allow immediate calculations or forecasts to be performed. However, it could guide in-depth scientific research in generating accurate forecasts and simulation using the tools of systems dynamics. In conclusion, understanding how global warming is created and if and how it could be controlled is the aim of this work. Finally, I want to note that the purpose of this work is not to analyze the technical aspects of the phenomenon of global warming, or to deepen the measures and actions to contrast it, but to provide a “general model of description and understanding” of the phenomenon using logic and language of the Systems Thinking Approach (according to Peter’s Senge and Piero Mella), with the aim of highlighting three fundamental strategic areas for countering the phenomenon and four uncontrollable phenomena, triggered by global warming itself, which can make strategic control difficult. Furthermore, I highlight the role played by the world population, understood both quantitatively as a number and qualitatively as a level of economic development, in the production of global warming. Lastly, I observe how the different strategic actions that nations can, indeed must, implement to stem global warming are systematically interconnected and interacting; however, these interactions can produce unknown effects and consequences that must be carefully researched and evaluated—encouraged, if positive, reduced or eliminated if negative.
Analysis of Gas-Turbine Type GT-009 M Low-Toxic Combustion Chamber with Impact Cooling of the Burner Pipe Based on Combustion of Preliminarily Prepared Depleted Air–Fuel Mixture
Authors: Maspanov Sergej , Bogov Igor , Smirnov Alexander , Martynenko Svetlana , Sukhanov Vladimir
Published: January 2022

This article analyzes the mechanism of formation of the main components of harmful emissions characteristic of combustion chambers operating on conventional hydrocarbon fuels. The method of combustion of a preliminarily prepared depleted air–fuel mixture was chosen as the object of the study. This method of suppressing harmful emissions was implemented in the design of a low-toxic combustion chamber developed as applied to the GT-009 M type unit with impact cooling of the burner pipe and provides for stabilization of the main kinetic flame by means of a diffusion-kinetic and a standby burner device. The results of the calculations performed with regard to the operating conditions of the low-toxic combustion chamber at the nominal load of GT-009 M allow us to conclude that the practical use of combustion of a depleted, preprepared, fuel–air mixture in combination with diffusion-kinetic stabilization of combustion is promising. The topic of this article is related to the problem of ecological improvement of gas turbine unit combustion chambers, which determines its utmost importance and relevance.
Non-Linear Switching Circuit for Active Voltage Rectification and Ripples Reduction of Piezoelectric Energy Harvesters
Authors: Edla Mahesh , Lim Yee Yan , Mikio Deguchi , Padilla Ricardo Vasquez
Published: January 2022

This paper describes an improved non-linear switching circuit (INLSC) for active rectification of voltage and reduction of ripples in the voltage waveform for the piezoelectric energy harvesting (PEH) system. The proposed converter controls the alternating current (AC) generated by the piezoelectric device (PD) under mechanical vibration. The proposed circuit combines the boost and buck-boost processes through a switching process, which functions in both positive and negative cycles. In addition, it controls the voltage and frequency of the load capacitor. In this process, the passive components in the circuit are energised by being short with the AC voltage using switching signals, which facilitates the active rectification of ultra-low AC voltage. Design considerations, theoretical analysis, simulations and experimental results are presented. It was shown that the circuit was able to control the switching signal and to convert low AC voltage (0.44 Vi) to high direct current (DC) voltage (6.5 Vdc) while achieving an output power of 469 µW which outperforms the existing similar circuits and synchronous rectifier circuit. The ripples in the rectified voltage were also comparatively less. Application-wise, the proposed circuit could power a manually connected 7-segments display, commonly used for traffic applications.
PV Generator-Fed Water Pumping System Based on a SRM with a Multilevel Fault-Tolerant Converter
Authors: Pires Vitor , Foito Daniel , Cordeiro Armando , Chaves Miguel , Pires Armando
Published: January 2022

This paper presents a pumping system supplied by a PV generator that is based on a switched reluctance machine (SRM). Water pumping systems are fundamental in many applications. Most of them can be used only during the day; therefore, they are highly recommended for use with PV generators. For the interface between the PV panels and the motor, a new multilevel converter is proposed. This converter is designed in order to ensure fault-tolerant capability for open switch faults. The converter is based on two three-level inverters, with some extra switches. Moreover, to reduce the number of switches, the converter is designed to provide inverse currents in the motor windings. Due to the characteristics of this motor, the inverse currents do not change the torque direction. In this way, it was possible to obtain an SRM drive with fault-tolerant capability for transistor faults; it is also a low-cost solution, due to the reduced number of switches and drives. These characteristics of fault-tolerant capability and low cost are important in applications such as water pumping systems supplied by PV generators. The proposed system was verified by several tests that were carried out by a simulation program. The experimental results, obtained from a laboratory prototype, are also presented, with the purpose of validating the simulation tests.
Residual Strength Assessment and Residual Life Prediction of Corroded Pipelines: A Decade Review
Authors: Li Haotian , Huang Kun , Zeng Qin , Sun Chong
Published: January 2022

Prediction of residual strength and residual life of corrosion pipelines is the key to ensuring pipeline safety. Accurate assessment and prediction make it possible to prevent unnecessary accidents and casualties, and avoid the waste of resources caused by the large-scale replacement of pipelines. However, due to many factors affecting pipeline corrosion, it is difficult to achieve accurate predictions. This paper reviews the research on residual strength and residual life of pipelines in the past decade. Through careful reading, this paper compared several traditional evaluation methods horizontally, extracted 71 intelligent models, discussed the publishing time, the evaluation accuracy of traditional models, and the prediction accuracy of intelligent models, input variables, and output value. This paper’s main contributions and findings are as follows: (1) Comparing several traditional evaluation methods, PCORRC and DNV-RP-F101 perform well in evaluating low-strength pipelines, and DNV-RP-F101 has a better performance in evaluating medium–high strength pipelines. (2) In intelligent models, the most frequently used error indicators are mean square error, goodness of fit, mean absolute percentage error, root mean square error, and mean absolute error. Among them, mean absolute percentage error was in the range of 0.0123–0.1499. Goodness of fit was in the range of 0.619–0.999. (3) The size of the data set of different models and the data division ratio was counted. The proportion of the test data set was between 0.015 and 0.4. (4) The input variables and output value of predictions were summarized.
Financial Analysis of Potential Carbon Value over 14 Years of Forest Restoration by the Framework Species Method
Authors: Jantawong Kanlayarat , Kavinchan Nuttira , Wangpakapattanawong Prasit , Elliott Stephen
Published: January 2022

The carbon storage value of forest restoration, by the framework species method (FSM) in northern Thailand, was assessed for trees (using a partial harvesting technique) and soil and compared with restoration costs. Forest carbon accumulation amounted to 143.08 tC/ha in trees and 8.56 tC/ha in soil over 14 years, with a combined value of USD 27,173.63 (net present value (NPV), discounted at 2.85%/year)) (at the current European carbon credit (EUA) price of 55.98 EUR/tCO2 = 242.21 USD/tC). Restoration costs increased from 2190.27 to 5680.72 USD/ha with declining pre-existing natural regeneration or 3.99–10.34 USD per ton of sequestered CO2. Profits over 14 years ranged in NPV from 22,215.45 to 25,157.04 USD/ha, breaking even from just over 4 years to just under 7, respectively. In contrast, profits from maize cultivation (a major regional deforestation driver) averaged 96.25 USD/ha/year, or just 1347.53 USD/ha over 14 years. Consequently, forest restoration could become a financially attractive alternative land use, provided an open, transparent, carbon market is created. Therefore, this study supports creation of a forest-carbon trading system in Thailand, to incentivize forest restoration and fire prevention, increase farmers’ incomes, reduce smoke-related public health problems, protect watersheds, and conserve biodiversity.
Impacts of Climate Change on Blue Carbon Stocks and Fluxes in Mangrove Forests
Authors: Alongi Daniel Michael
Published: January 2022

Mangroves store blue carbon (693 Mg CORG ha−1) disproportionate to their small area, mainly (74%) in deep soil horizons. Global stock estimates for mangroves (5.23–8.63 Pg CORG) are equivalent to 15–24% of those in the tropical coastal ocean. Carbon burial in mangrove soils averages 184 g CORG m−2 a−1 with global estimates (9.6–15.8 Tg CORG a−1) reflecting their importance in carbon sequestration. Extreme weather events result in carbon stock losses and declines in carbon cycling and export. Increased frequency and ferocity of storms result in increasingly negative responses with increasing strength. Increasing temperatures result in increases in carbon stocks and cycling up to a critical threshold, while positive/negative responses will likely result from increases/decreases in rainfall. Forest responses to sea-level rise (SLR) and rising CO2 are species- and site-specific and complex due to interactive effects with other drivers (e.g., temperature, salinity). The SLR critical threshold is ≈ 6 mm a−1 indicating survival only under very low-low CO2 emissions scenarios. Under low coastal squeeze, landward migration could result in sequestration and CO2 losses of 1.5 and −1.1 Pg C with net stock gains and losses (−0.3 to +0.5 Pg C) and CO2 losses (−3.4 Pg) under high coastal squeeze.
Optimization of 2-Phenylethanol Production from Sweet Whey Fermentation Using Kluyveromyces marxianus
Authors: Alonso-Vargas Monserrat , Téllez-Jurado Alejandro , Gómez-Aldapa Carlos A. , Ramírez-Vargas María del Rocío , Conde-Báez Laura , Castro-Rosas Javier , Cadena-Ramírez Arturo
Published: January 2022

The growing demand for natural products benefits the development of bioprocesses to obtain value-added compounds using residues such as sweet whey, which is rich in lactose. The yeast Kluyveromyces marxianus can ferment sweet whey to obtain 2-phenylethanol (2-PhEtOH), which is a superior alcohol with a rose aroma. Such fermentation only requires the addition of L-phenylalanine (precursor) and (NH4)2SO4 (salt). Therefore, it was sought to improve the fermentation conditions to produce 2-PhEtOH, which, in turn, would achieve the maximum decrease in the Chemical Oxygen Demand (COD) of the fermentation medium. With the use of the Response Surface Methodology and the application of a Central Composite Design for optimization, two parameters were evaluated as a function of time: salt concentration and precursor. The experimental data were adjusted to a second order polynomial, identifying that the precursor concentration presents a statistically significant effect. The best conditions were: 4.50 g/L of precursor and 0.76 g/L of salt, with a maximum production of 1.2 g/L (2-PhEtOH) at 48 h and achieving a maximum percentage of COD removal of 76% at 96 h. Finally, the optimal conditions were experimentally validated, recommending the use of the model.
Statistical Error for Cosmic Rays Modulation Evaluated by SDE Backward in Time Method for 1D Model
Authors: Mykhailenko Viacheslav , Bobik Pavol
Published: January 2022

The propagation of cosmic rays through the heliosphere has been solved for more than half a century by stochastic methods based on Ito’s lemma. This work presents the estimation of statistical error of solution of Fokker–Planck equation by the 1D backward in time stochastic differential equations method. The error dependence on simulation statistics and energy is presented for different combinations of input parameters. The 1% precision criterion in mean value units of intensity standard deviation is defined as a function of solar wind velocity and diffusion coefficient value.
On the Existence and Stability of Variable Order Caputo Type Fractional Differential Equations
Authors: Sarwar Shahzad
Published: January 2022

In the theory of differential equations, the study of existence and the uniqueness of the solutions are important. In the last few decades, many researchers have had a keen interest in finding the existence–uniqueness solution of constant fractional differential equations, but literature focusing on variable order is limited. In this article, we consider a Caputo type variable order fractional differential equation. First, we present the existence–uniqueness of a solution of the considered problem. Secondly, By borrowing the idea from the theory of ordinary differential equations, we extend the continuation theorem for the variable order fractional differential equation. Further, we prove the global existence results. Finally, we present different types of Ulam–Hyers stability results, which have never been studied before for the Caputo type variable order fractional differential equation.
The Special Features of Prenatal and Preimplantation Genetic Counseling in Arab Countries
Authors: Malik Shaza D. , Al-Shafai Mashael , Abdallah Atiyeh M.
Published: January 2022

Genetic counseling services have only recently been introduced in most Arab countries, and their utilization is increasing. Prenatal genetic counseling is essential, particularly in the Arab context, which is characterized by high rates of consanguinity. Nevertheless, little is known about the decisions faced by parents and the factors underlying the complex decision making that must occur when accessing these services in Arab countries. Herein, we performed a narrative review to discuss the reported experiences of parents accessing genetic counseling in the prenatal setting in the 22 Arab countries. We also highlight the different types of decisions encountered and the factors influencing them. We report that: (i) utilization of genetic counseling services varies across different Arab countries; (ii) many factors affect decision making and service utilization, especially religion; and (iii) parents are faced with an array of decisions in the prenatal setting, partly driven by increased utilization of prenatal diagnosis and preimplantation genetic testing in some countries. Our work is the first to highlight the different factors and decisions influencing genetic counseling in Arab countries. Understanding these factors is essential for improving genetic counseling services in the region and helping counselors facilitate informed decision making.
LMNA Mutation in a Family with a Strong History of Sudden Cardiac Death
Authors: Keil Laura , Berisha Filip , Knappe Dorit , Kubisch Christian , Shoukier Moneef , Kirchhof Paulus , Fabritz Larissa , Hellenbroich Yorck , Woitschach Rixa , Magnussen Christina
Published: January 2022

We report a family with heterozygous deletion of exons 3–6 of the LMNA gene. The main presentation of affected family members was characterized by ventricular and supraventricular arrhythmias, atrioventricular (AV) block and sudden cardiac death (SCD) but also by severe dilative cardiomyopathy (DCM). We report on two siblings, a 36-year-old female and her 40-year-old brother, who suffer from heart failure with mildly reduced ejection fraction, AV conduction delays and premature ventricular complexes. Their 65-year-old mother underwent heart transplantation at the age of 55 due to advanced heart failure. Originally, the LMNA mutation was detected in one of the uncles. This index patient and three of his brothers died of SCD as well as their father and aunt. The two siblings were treated with implanted defibrillators in our specialized tertiary heart failure center. This case report places this specific genetic variant in the context of LMNA-associated familial DCM.
Thirteen Tactics for Teaching Poetry as Architecture
Authors: Bryant Marsha , Hailey Charlie
Published: January 2022

What if encounters between modernist poetry and architecture exceed inspiration, imagery, and allusions? These two modes of making have crossed boundaries for over a century, from Walt Whitman’s ecstatic stanzas on Manhattan skyscrapers to architect John Hejduk’s poetry of memory and place. Buildings become materials for poetry, and poems become material for building. When a literary critic and an architect build on overlaps they have discovered in syllabi for American Poetry and Architecture Studio courses, their teaching collaboration becomes a sustainable maker-space for student work—and for the Humanities more generally. We found that linking a literature survey to an architectural design studio brings materiality and resourcefulness to working with poems and that interacting with the Humanities demonstrates praxis (theory + practice) from the perspective of architectural pedagogy. Our classes also engaged each other through The Repurpose Project, a community space that promotes reuse and diverts waste from the local landfill. The profusion of readily available materials at Repurpose afforded students with a rich sampling of architectural textures and languages, opening new possibilities for thinking and making. In an academic climate that groups literary studies and architecture as “not-STEM,” we designed sustainable and resilient pedagogies that go beyond problem solving. Finding the same quality of renewable resourcefulness in Wallace Stevens’s “Thirteen Ways of Looking at a Blackbird,” we offer 13 tactics for teaching poetry as architecture.
Estimation of Ecotourism Carrying Capacity for Sustainable Development of Protected Areas in Iran
Authors: Sobhani Parvaneh , Esmaeilzadeh Hassan , Sadeghi Seyed Mohammad Moein , Marcu Marina Viorela
Published: January 2022

Estimating the ecotourism carrying capacity (ETCC) in protected areas (PAs) is essential for minimizing the negative impacts of ecotourism and sustainable environmental management. PAs are one of the prominent ecotourism locations and many of these areas have been created to protect biodiversity and improve human wellbeing. This study has identified and prioritized negative impacts of ecotourism in Lar national park, the Jajrud protected area with the sustainable use of natural resources, and Tangeh Vashi national natural monument. For this purpose, physical carrying capacity (PCC), real carrying capacity (RCC), and effective carrying capacity (ECC) were estimated using the ETCC model. The results indicated that due to these areas’ ecological sensitivity, the most negative impacts of ecotourism are related to the environmental-physical dimensions. In contrast, the lowest impacts have been observed in the economic-institutional dimensions. Moreover, the results revealed that the highest PCC is related to Lar national park, and the lowest PCC is associated with Tangeh Vashi natural monument. There are more tourists in the Jajrud protected area with the sustainable use of natural resources than other areas in RCC and ECC due to low levels of restrictions and legal instructions. In contrast, in Lar national park and Tangeh Vashi natural monument, due to the short duration of ecotourism in these areas (from June to October), high level of restrictions, and ecological sensitivity, the number of tourists is less than the RCC and ECC. As these areas have a limited ability to attract visitors and ecotourism, the protection of these areas requires the implementation of sustainable management to control the negative impacts of ecotourism and estimate the number of visitors.
Stabilization/Solidification of Heavy Metals and PHe Contaminated Soil with β-Cyclodextrin Modified Biochar (β-CD-BC) and Portland Cement
Authors: Li Geng , Li Haibo , Li Yinghua , Chen Xi , Li Xinjing , Wang Lixin , Zhang Wenxin , Zhou Ying
Published: January 2022

Conventional stabilization/solidification materials have defects in the simultaneous treatment of heavy metals (HMs) and phenanthrene (PHe). In order to solve this problem, a new functional material β-cyclodextrin modified biochar (β-CD-BC) was prepared by integrating the properties of biochar (BC) and the hydrophilic and hydrophobic properties of the β-CD surface and combined with Portland cement (PC) to cure and stabilize HMs and PHe. The effect of key parameters on the treatment effect was discussed by response surface method. The results showed that the minimum leaching concentration if HMs was 16.81 mg·L−1, and the leaching concentration of PHe can be as low as 0.059 μg/kg under the conditions of β-CD-BC and Portland cement ratio of 9.75% and 11.4%, curing for 22.85 d. The weak acid soluble state reduced from 9~13% to 0.5~6%, the residual state was increased from 37~61% to 77~87%. The unconfined compressive strength of sample is more than 50 kPa. The results of this study can provide a new technical scheme for long-term curing and stabilization of HMs and PHe.
The Relationship between Future Anxiety Due to COVID-19 and Vigilance: The Role of Message Fatigue and Autonomy Satisfaction
Authors: Lee-Won Roselyn J. , Jang Inyoung , Kim Hyun-Suk , Park Sung-Gwan
Published: January 2022

How does future anxiety caused by the COVID-19 pandemic relate to people’s willingness to remain vigilant and adhere to preventive measures? We examined the mediating role of message fatigue and the moderating role of autonomy satisfaction in the relationship between future anxiety due to COVID-19 and willingness to remain vigilant. A cross-sectional online survey was conducted with adults residing in the United States in June 2021 when numerous U.S. states re-opened following the CDC’s relaxed guidelines for fully vaccinated individuals. Our data showed that message fatigue mediated the relationship between future anxiety due to the pandemic and willingness to remain vigilant. The data further revealed that autonomy satisfaction significantly moderated the mediation. Namely, the role of message fatigue in the indirect relationship between future anxiety and willingness to remain vigilant was significant only among people low to moderate in autonomy satisfaction; its role in the indirect path was not significant for those high in autonomy satisfaction. Notably, independent of the mechanism involving message fatigue, future anxiety was directly and positively associated with willingness to remain vigilant regardless of the levels of autonomy satisfaction. Implications of these findings are discussed in light of psychological and behavioral responses to the current pandemic and policy directions.
Barriers and Concerns in Providing Sex Education among Children with Intellectual Disabilities: Experiences from Malay Mothers
Authors: Kamaludin Nawal Nabilah , Muhamad Rosediani , Mat Yudin Zainab , Zakaria Rosnani
Published: January 2022

Though sex education (SE) may benefit the sexual development and overall well-being of children with intellectual disabilities (IDs), obstacles to its implementation remain. This study highlights barriers and concerns of SE for children with IDs based on their mothers’ experiences. We employed a phenomenological approach and in-depth interviews with twenty Malay mothers of children with mild-to-moderate IDs or/and other neurodevelopmental disorders. Four primary hurdles to SE were discovered: (1) mother (2) children (3) family value, and (4) socio-cultural environment. Inadequate knowledge, mothers’ perceptions that SE is less necessary at this stage of their children’s development, and time constraints were among their main barriers. Another source of hardship was the communication barrier because children with ID have cognitive impairment in their capacity to understand the topic being addressed and more time should be spent throughout the discussion. Family value and socio-cultural elements also had an impact on mothers’ intention to deliver SE to their children. Our findings suggest that mothers recognize the importance of SE for their children’s well-being. However, the dynamic interaction between the barriers complicates SE. This study emphasizes the necessity for future interventions to overcome hurdles at each level to effectively implement the recommended strategies.
A Scoping Review of Concussion Guidelines in Amateur Sports in the United Kingdom
Authors: Scullion Emer , Heron Neil
Published: January 2022

Objectives To investigate which United Kingdom (UK) amateur sporting organisations have published sports-related concussion (SRC) guidelines, their accessibility and the extent to which they follow the Berlin statement recommendations. This article is targeted at those involved with designing and implementing SRC guidelines in amateur sport. Design Scoping Review. Data Sources The SRC guidelines of 15 sporting organisations were accessed through public materials available from the official organisation website. Eligibility Criteria: To be included in this review, sports must enjoy broad participation by UK amateur athletes with a high risk of athletes sustaining an SRC. Results: 15 sporting organisations were included in this review with two, British Cycling and British Eventing, found not to have published SRC guidelines. There was found to be a large discrepancy between the extent to which the sport-specific guides followed the Berlin statement recommendations. Conclusions: The large discrepancy between the contents of the SRC guidelines may be putting the health of athletes at risk. We recommend the UK government publish standardised concussion guidelines based on the latest scientific research that must be used by all UK amateur sport groups.
Outcomes and Mechanisms of Change of the Strengthening Families Program in a Clinical Sample of Children and Their Families in Austria
Authors: Stefanek Elisabeth , Bleis Tanja , Schwab Markus , Spiel Georg
Published: January 2022

Family context and parenting behavior have the greatest influence on children’s mental health and well-being, and interventions that take the whole family system into account are promising. This study aims to evaluate the outcomes, i.e., family strength, parenting behavior, and child behavior, of the Strengthening Families Program (SFP), developed by Kumpfer which was implemented in an outpatient clinic of a community-based non-governmental organization in Austria between 2012 and 2018. Furthermore, the program’s mechanism of change as formulated by the program authors (i.e., to what extent parenting behavior mediates the relationship between family strength and child behavior) was tested in this clinical sample. Instruments measuring family strength, parenting behavior, and child behavior were administered before, immediately after, and 6 months after participation in the SFP. To test the mechanisms of change, a half-longitudinal model was applied with two measurement points (before and after). A total of 62 families (50 boys, 24 girls, and 69 parents) participated in the culturally adapted SFP. Regarding the outcomes of the program, all variables yielded significant improvement in all variables. With respect to the mechanism of change, no significant association between the variables could be found. Implications for the implementation of the SFP in a clinical population and how further adaptation of the program could enhance the adherence of this target group are discussed.
Effects of Road Traffic on the Accuracy and Bias of Low-Cost Particulate Matter Sensor Measurements in Houston, Texas
Authors: Oluwadairo Temitope , Whitehead Lawrence , Symanski Elaine , Bauer Cici , Carson Arch , Han Inkyu
Published: January 2022

Although PM2.5 measurements of low-cost particulate matter sensors (LCPMS) generally show moderate and strong correlations with those from research-grade air monitors, the data quality of LCPMS has not been fully assessed in urban environments with different road traffic conditions. We examined the linear relationships between PM2.5 measurements taken by an LCPMS (Dylos DC1700) and two research grade monitors, a personal environmental monitor (PEM) and the GRIMM 11R, in three different urban environments, and compared the accuracy (slope) and bias of these environments. PM2.5 measurements were carried out at three locations in Houston, Texas (Clinton Drive largely with diesel trucks, US-59 mostly with gasoline vehicles, and a residential home with no major sources of traffic emissions nearby). The slopes of the regressions of the PEM on Dylos and Grimm measurements varied by location (e.g., PEM/Dylos slope at Clinton Drive = 0.98 (R2 = 0.77), at US-59 = 0.63 (R2 = 0.42), and at the residence = 0.29 (R2 = 0.31)). Although the regression slopes and coefficients differed across the three urban environments, the mean percent bias was not significantly different. Using the correct slope for LCPMS measurements is key for accurately estimating ambient PM2.5 mass in urban environments.
The Value of Clinical Frailty Scale (CFS) as a Prognostic Tool in Predicting Mortality in COVID-19—A Retrospective Cohort Study
Authors: Jachymek Magdalena , Cader Aleksandra , Ptak Michał , Witkiewicz Wojciech , Szymański Adam Grzegorz , Kotfis Katarzyna , Kaźmierczak Jarosław , Szylińska Aleksandra
Published: January 2022

Background: Due to the unpredictable nature of COVID-19, there is a need to identify patients at high risk of severe course of the disease and a higher mortality rate. Objective: This study aims to find the correlation between frailty and mortality in adult, hospitalized patients with COVID-19. Methods: Clinical records of 201 patients who suffered from COVID-19 and were hospitalized between October 2020 and February 2021 were retrospectively analyzed. Demographic, clinical, and biochemical data were collected. Patients were assessed using Clinical Frailty Scale (CFS) and were divided into three groups: CFS 1–3 fit; CFS 4–6 vulnerable and with mild to moderate frailty; CSF 7–9, severe frailty. The association between frailty and in-hospital mortality was the primary outcome. Results: Severe frailty or terminal illness was observed in 26 patients (12.94%) from a cohort of 201 patients. Those patients were older (median age 80.73, p < 0.001) and had more comorbidities. Frailty was also associated with higher requirement for oxygen supplementation, greater risk of in-hospital complications and worse biochemical laboratory results. An increase in CFS score also correlated with higher mortality (OR = 1.89, p < 0.001). The Conclusions: Clinical Frailty Scale (CFS) can be used as a potentially useful tool in predicting mortality in patients with COVID-19.
Non-Epithelial Ovarian Cancers: How Much Do We Really Know?
Authors: Cheung Alison , Shah Sidrah , Parker Jack , Soor Pavandeep , Limbu Anu , Sheriff Matin , Boussios Stergios
Published: January 2022

Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely rare tumours, such as small cell carcinomas and sarcomas. Each of these classifications encompasses multiple histologic subtypes. The aetiology and molecular origins of each sub-group of NEOC require further investigation, and our understanding on the genetic changes should be optimised. In this article, we provide an update on the clinical presentation, pathology, genetics, treatment and survival of the main histological subtypes of the GCT and the SCST, as well as of ovarian small cell carcinomas. We also discuss miRNA expression profiles of NEOC and report the currently active clinical trials that include NEOC.
Geospatial Modeling Approaches to Historical Settlement and Landscape Analysis
Authors: Herold Hendrik , Behnisch Martin , Hecht Robert , Leyk Stefan
Published: January 2022

Landscapes and human settlements evolve over long periods of time. Land change, as one of the drivers of the ecological crisis in the Anthropocene, therefore, needs to be studied with a long-term perspective. Over the past decades, a substantial body of research has accumulated in the field of land change science. The quantitative geospatial analysis of land change, however, still faces many challenges; be that methodological or data accessibility related. This editorial introduces several scientific contributions to an open-access Special Issue on historical settlement and landscape analysis. The featured articles cover all phases of the analysis process in this field: from the exploration and geocoding of data sources and the acquisition and processing of data to the adequate visualization and application of the retrieved historical geoinformation for knowledge generation. The data used in this research include archival maps, cadastral and master plans, crowdsourced data, airborne LiDAR and satellite-based data products. From a geographical perspective, the issue covers urban and rural regions in Central Europe and North America as well as regions subject to highly dynamic urbanization in East Asia. In the view of global environmental challenges, both the need for long-term studies on land change within Earth system research and the current advancement in AI methods for the retrieval, processing and integration of historical geoinformation will further fuel this field of research.
Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen
Authors: Popovic Grega , Kirby Nicholas C. , Dement Taylor C. , Peterson Kristine M. , Daub Caroline E. , Belcher Heather A. , Guthold Martin , Offenbacher Adam R. , Hudson Nathan E.
Published: January 2022

Fibrin forms the structural scaffold of blood clots and has great potential for biomaterial applications. Creating recombinant expression systems of fibrinogen, fibrin’s soluble precursor, would advance the ability to construct mutational libraries that would enable structure–function studies of fibrinogen and expand the utility of fibrin as a biomaterial. Despite these needs, recombinant fibrinogen expression systems, thus far, have relied on the time-consuming creation of stable cell lines. Here we present tests of a transient fibrinogen expression system that can rapidly generate yields of 8–12 mg/L using suspension HEK Expi293TM cells. We report results from two different plasmid systems encoding the fibrinogen cDNAs and two different transfection reagents. In addition, we describe a novel, affinity-based approach to purifying fibrinogen from complex media such as human plasma. We show that using a high-affinity peptide which mimics fibrin’s knob ‘A’ sequence enables the purification of 50–75% of fibrinogen present in plasma. Having robust expression and purification systems of fibrinogen will enable future studies of basic fibrin(ogen) biology, while paving the way for the ubiquitous use of fibrin as a biomaterial.
Changes of Gut Microbiota by Natural mtDNA Variant Differences Augment Susceptibility to Metabolic Disease and Ageing
Authors: Künstner Axel , Schilf Paul , Busch Hauke , Ibrahim Saleh M. , Hirose Misa
Published: January 2022

We recently reported on two mouse strains carrying different single nucleotide variations in the mitochondrial complex I gene, i.e., B6-mtBPL mice carrying m.11902T>C and B6-mtALR carrying m.4738C>A. B6-mtBPL mice exhibited a longer lifespan and a lower metabolic disease susceptibility despite mild mitochondrial functional differences in steady-state. As natural polymorphisms in the mitochondrial DNA (mtDNA) are known to be associated with distinct patterns of gut microbial composition, we further investigated the gut microbiota composition in these mice strains. In line with mouse phenotypes, we found a significantly lower abundance of Proteobacteria, which is positively associated with pathological conditions, in B6-mtBPL compared to B6-mtALR mice. A prediction of functional profile of significantly differential bacterial genera between these strains revealed an involvement of glucose metabolism pathways. Whole transcriptome analysis of liver samples from B6-mtBPL and B6-mtALR mice confirmed these findings. Thus, both host gene expression and gut microbial changes caused by the mtDNA variant differences may contribute to the ageing and metabolic phenotypes observed in these mice strains. Since gut microbiota are easier to modulate, compared with mtDNA variants, identification of such mtDNA variants, specific gut bacterial species and bacterial metabolites may be a potential intervention to modulate common diseases, which are differentially susceptible to individuals with different mtDNA variants.
Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer’s, and Parkinson’s Diseases
Authors: Raha Animesh Alexander , Biswas Anwesha , Henderson James , Chakraborty Subhojit , Holland Anthony , Friedland Robert P. , Mukaetova-Ladinska Elizabeta , Zaman Shahid , Raha-Chowdhury Ruma
Published: January 2022

Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Down syndrome (DS) dementia. However, the mechanisms of iron deposition and regional selectivity in the brain are ill-understood. The identification of several proteins that are involved in iron homeostasis, transport, and regulation suggests avenues to explore their function in neurodegenerative diseases. To uncover the molecular mechanisms underlying this association, we investigated the distribution and expression of these key iron proteins in brain tissues of patients with AD, DS, PD, and compared them with age-matched controls. Ferritin is an iron storage protein that is deposited in senile plaques in the AD and DS brain, as well as in neuromelanin-containing neurons in the Lewy bodies in PD brain. The transporter of ferrous iron, Divalent metal protein 1 (DMT1), was observed solely in the capillary endothelium and in astrocytes close to the ventricles with unchanged expression in PD. The principal iron transporter, ferroportin, is strikingly reduced in the AD brain compared to age-matched controls. Extensive blood vessel damage in the basal ganglia and deposition of punctate ferritin heavy chain (FTH) and hepcidin were found in the caudate and putamen within striosomes/matrix in both PD and DS brains. We suggest that downregulation of ferroportin could be a key reason for iron mismanagement through disruption of cellular entry and exit pathways of the endothelium. Membrane damage and subsequent impairment of ferroportin and hepcidin causes oxidative stress that contributes to neurodegeneration seen in DS, AD, and in PD subjects. We further propose that a lack of ferritin contributes to neurodegeneration as a consequence of failure to export toxic metals from the cortex in AD/DS and from the substantia nigra and caudate/putamen in PD brain.
Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved Drosophila melanogaster Populations
Authors: Phillips Mark A. , Arnold Kenneth R. , Vue Zer , Beasley Heather K. , Garza-Lopez Edgar , Marshall Andrea G. , Morton Derrick J. , McReynolds Melanie R. , Barter Thomas T. , Hinton Antentor
Published: January 2022

Experimental evolution with Drosophila melanogaster has been used extensively for decades to study aging and longevity. In recent years, the addition of DNA and RNA sequencing to this framework has allowed researchers to leverage the statistical power inherent to experimental evolution to study the genetic basis of longevity itself. Here, we incorporated metabolomic data into to this framework to generate even deeper insights into the physiological and genetic mechanisms underlying longevity differences in three groups of experimentally evolved D. melanogaster populations with different aging and longevity patterns. Our metabolomic analysis found that aging alters mitochondrial metabolism through increased consumption of NAD+ and increased usage of the TCA cycle. Combining our genomic and metabolomic data produced a list of biologically relevant candidate genes. Among these candidates, we found significant enrichment for genes and pathways associated with neurological development and function, and carbohydrate metabolism. While we do not explicitly find enrichment for aging canonical genes, neurological dysregulation and carbohydrate metabolism are both known to be associated with accelerated aging and reduced longevity. Taken together, our results provide plausible genetic mechanisms for what might be driving longevity differences in this experimental system. More broadly, our findings demonstrate the value of combining multiple types of omic data with experimental evolution when attempting to dissect mechanisms underlying complex and highly polygenic traits such as aging.
Biodiversity of Forensically Relevant Blowflies (Diptera: Calliphoridae) at the Anthropology Research Facility in Knoxville, Tennessee, USA
Authors: Jeong Yangseung , Weidner Lauren M. , Pergande Simon , Gemmellaro Denise , Jennings David E. , Hans Krystal R.
Published: January 2022

Understanding the biodiversity and distribution of forensically relevant blowflies (Diptera: Calliphoridae) in a region can aid in legal investigations when insects are associated with remains. For this purpose, we conducted a 14-month-long blowfly survey at the Anthropology Research Facility (ARF) of the University of Tennessee in Knoxville, Tennessee. Traps baited with pork kidney were deployed for 24 h twice a month throughout the study. A total of 3180 adult blowflies were collected, comprising 13 species from 7 genera. Phormia regina (Meigen) and Lucilia coeruleiviridis (Macquart) were the predominant species collected from this survey, with collections representing 65.9% and 20.6%of total flies captured, respectively. In addition to relative abundance, we investigated blowfly community composition, species abundance, richness, and diversity by season. One state record was identified, with adult Protophormia terraenovae (Robineau-Desvoidy) being collected for the first time in Tennessee. Additionally, an earlier record of Chrysomya megacephala (Fabricius) in Tennessee was noted. These findings can be used to aid in legal investigations in the area and surrounding areas where work is limited, as well as to provide information on which forensically relevant species should be the subject of future research in the area.