bluuebunny/crossref_metadata_2025 huggingface dataset:
Internet memes as heritage in becoming and its problems: The methodology of heritization and the formation of cultural memory in cyberspace
Authors: Knezevic Ana
Published: November 2023

After defining Internet memes and their place within broader popular culture, this paper examines the methodology and interpretation of a large-scale collection of Internet memes used by the KnowYourMeme database. By observing the changed context in which Internet memes are created, shared, or forgotten, questions are raised about the formation of meme cultural memory in cyberspace, leading to critical commentary on the ways in which they are collected. By analyzing the heritization of Internet memes, this paper addresses the following issues: the formation of the future meme heritage, scope of cultural memory in cyberspace, redefinition of remembering and forgetting within the panmnemonic tendencies of online heritage projects. Using the KnowYourMeme database as an example, the problems of cyberspace heritage are discussed, and the different online projects dealing with Internet memes as heritage are compared. By defining ?on-the-fly? memory, which indicates the simultaneity of the process of creating and preserving heritage, this paper offers a critical review of the existing cyber projects of ?saving everything?.
Bærekraftig utvikling. En begrepsundersøkelse
Authors: Lindholm Markus
Published: November 2023

Artikkelen foretar en kritisk undersøkelse av begrepsparet bærekraftig utvikling, med utgangspunkt i deres idehistoriske røtter. Utviklingsbegrepet ble aktualisert i opplysningstiden, og kan knyttes til Nicolas de Condorcets ide om økt perfektibilitet både for enkeltmennesker og samfunn. Begrepet bærekraft tok form som et motsvar til den nye utviklingsoptimismen og knyttes til Thomas Malthus, som mente at perfektibilitet og utvikling var umulig, og at Gud hadde skapt et misforhold mellom befolkningsvekst og ressurstilgang. Det samme misforholdet ble sentralt for Darwins teori om evolusjon ved naturlig seleksjon, der økosystemisk stabilitet er forutsetningen for konkurranse om begrensede ressurser og gradvise tilpasninger. Utvikling, på den annen side, forutsetter ubalanse. Språkfiguren bærekraftig utvikling er følgelig et oksymoron. Mulige faktorer som kan ha bidratt til økt aksept for språkfigurer uten mening drøftes i lys av underholdningsindustrien, mem-teori og postmodernisme, og blir deretter undersøkt i lys av Harry Frankfurts term bullshit.
Konklusjonen er at bærekraftig utvikling, slik det vanligvis brukes, ikke uten videre er pedagogisk egnet for skole og utdanning. Å behandle språkkonstruksjoner som om de var konsistente begreper bidrar heller til å lamslå elevenes tenkeevne. Artikkelen slutter likevel med å peke ut mulige retninger for å behandle bærekraftig utvikling i en meningsgivende pedagogisk kontekst.
PENGARUH BRAND AMBASSADOR DAN BRAND IMAGE TERHADAP KEPUTUSAN PEMBELIAN PRODUK ERIGO PADA MAHASISWA UNIVERSITAS TRUNOJOYO
Authors: Maghfirah Vira , Suyono Suyono
Published: November 2023

Penelitian ini di latar belakangi oleh semakin banyaknya brand fashion lokal yang muncul di Indonesia. Setiap merek fashion memiliki keunggulan masing-masing, sehingga pembeli harus mempertimbangkan penampilan berbagai merek fashion di Indonesia. Salah satunya Erigo. Erigo bekerja sama dengan sejumlah orang terkenal untuk mempromosikan produk mereka sebagai brand ambassador. Tujuan penelitian ini yaitu untuk mengetahui pengaruh brand ambassador dan brand image terhadap keputusan pembelian produk Erigo. Subjek penelitian ini adalah mahasiswa Fakultas Ekonomi dan Bisnis Universitas Trunojoyo Madura yang pernah membeli Erigo. Jenis penelitian ini menggunakan metode kuantitatif. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah purposive sampling dengan jumlah sampel sebanyak 100 responden. Teknik pengumpulan data dengan menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya. Teknik analisis data yang digunakan adalah analisis linear berganda. Hasil penelitian dengan menggunakan uji t menunjukkan variabel brand ambassador dan brand image berpengaruh signifikan terhadap keputusan pembelian. Dari hasil bersama-sama (uji f) menunjukkan bahwa variabel brand ambassador dan brand image berpengaruh secara simultan terhadap keputusan pembelian.
Anatomo-Phylogenetic Arguments for the Production of Muscular Sports Injuries
Authors:   Faculty of Physical Education and Sports, Alexandru Ioan Cuza University, Iași, Romania. Email: bogdan_hagiu@yahoo.com., Hagiu Bogdan-Alexandru
Published: November 2023

"The striated muscles that appeared later on the phylogenetic scale have more white, fast fibers in their composition, more sensitive to metabolic aggression. Based on the composition, phylogeny and anatomical-functional characteristics, we selected the following muscles: semitendinosus, iliac, subscapular, extensor pollicis brevis and flexor pollicis longus. The data from the specialized literature show that the respective muscles are exposed to sports injuries. In principle, one can try to prevent injuries by changing the proportions in types of muscle fibers, possibly through physical exercises, but there is the potential danger of changing joint biomechanics. Keywords: striated muscles, phylogeny, fiber types, sports traumatology."
The Role of Communication in Teaching Swimming
Authors:   PhD student, Science of Education, Faculty of Psychology and Educational Sciences, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: tudy_palu@yahoo.com., Pop Tudor Andrei
Published: November 2023

"The present research study includes, in the first part, the synthesis of the literature regarding the theoretical framework of meaning construction, from information theory to the semiotics of reception and the concept of “horizon of expectation” in the reception of the teacher’s linguistic productions, and in the second part, it includes the research methodology. The results of the research identify the average frequency of responses for all situations. After the study took place resulted 6 important findings like a direct and unambiguous reading strategy for the teacher (P), a considerable loss of meaning between the teacher’s language production and the student’s reception, higher reading fluency in the GE group, reading difficulties in GT group, recognition of meaning is earlier and more relevant in GE, and the fact that verbal productions make it possible to complete sequence, a misunderstanding for GT. The conclusions reveal that the messages transmitted through verbal and non-verbal teacher-student communication are received rather by connotation than by denotation. Keywords (in English): teaching swimming, learning and teaching of swimming, communication, semiotics, linguistic productions."
The Contribution of Constructivism in Teaching Swimming
Authors:   PhD student, Science of Education, Faculty of Psychology and Educational Sciences, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: tudy_palu@yahoo.com., Pop Tudor Andrei
Published: November 2023

"This article aims to take stock of the possible contribution of constructivism to the renewal of the pedagogy of swimming. If the pedagogies oriented by constructivism have profoundly renewed the ways of understanding the teaching of team sports, the same is not true with regard to the teaching of sports disciplines that are predominantly technical. By identifying the differences and the points in common between the various forms of constructivism, the article proposes a pedagogical framework oriented by this epistemology that can be mobilized in the teaching of swimming. Two case studies and their consequences for learning are proposed in the teaching of butterfly and breaststroke techniques. Keywords: teaching swimming, learning and teaching of swimming, constructivist perspective."
Island Peak – a Popular Destination for Mountaineering in the Himalayas. Methodological and Practical Aspects
Authors:   Faculty of Geography, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: john_grimo@yahoo.com., Bîca Ioan
Published: November 2023

"Island Peak is located in the Solu-Khumbu region of the Himalayas (Nepal), and is a destination for beginner climbers, for acclimatization (at the altitude of 5000-6000 m), and training (practicing techniques for moving on exposed rock and ice, traversing crevasses on metal ladders, climbing on fixed ropes, moving on ice ledges, abseiling). The popularity of the massif is because it was noticed and climbed for the first time by members of the British expedition in 1953, but also from other causes, such as: easy access on the Dinboche-Chukkung-PareshayaGyab route; the short and relatively easy standard ascent route, but with enough technical challenges (slope, exposed rock, ice plateau with crevasses, ice wall, and exposed rock, narrow ridge with ice ledges), the passage of which is good training for climbing peaks above 7000 m and testing climbing skills; the proximity of the southern face of the Lhotse Peak; scenic perspectives towards Lhotse summit (8516 m), to the Imja, Lhotse Shar, and Lhotse glaciers, to the Baruntse ridge (7000 m), and the iconic Ama Dablam Peak (6856 m).The basic work is the result of direct research carried out by the author on the Island Peak massif and highlights, on the one hand, its geomorphological features, and on the other hand, the methodological stages of organizing and carrying out an expedition on this peak, relevant from sport and medical point of view. Keywords: climbing, trekking, mountaineering, Everest Base Camp Trek, summit day."
Enseñando y aprendiendo en pandemia
Authors: Castro Agustina , Sáenz Alejandro Julio , Ateiro Claudia Marcela , Dumrauf Sergio , García Jenifer Angelita , Duré Vicenta Soledad , Funes Adriana Candelaria , Fontana Paula Andrea
Published: November 2023

La pandemia de COVID-19 generó profundos desafíos en las instituciones educativas. Como respuesta para garantizar la continuidad pedagógica de los/as estudiantes, muchas Universi-dades, entre ellas la Universidad Nacional de La Plata, decidieron continuar las cursadas con la modalidad virtual. En la Facultad de Ciencias Veterinarias, el curso de Economía General y Sociología, corres-pondiente al segundo año de la carrera, se dicta en el primer cuatrimestre del ciclo lectivo. El presente trabajo tuvo como objetivo analizar la importancia del uso de una encuesta al inicio de la cursada del primer cuatrimestre del año 2020, como herramienta para poder repensar y replanificar el curso ante el escenario de emergencia sanitaria.
Uso dos recursos tecnológicos digitais por professores de duas instituições de ensino superior no Brasil
Authors: Paula Rejane Sales de Lima , Casarin Helen de Castro Silva , Almeida Cátia Cândida de , Lucas Margarida
Published: November 2023

Este artigo apresenta os resultados sobre o uso dos recursos digitais por professores de ensino superior de duas instituições públicas brasileiras a partir da área 2 do DigCompEdu. Trata-se de um estudo descritivo-inferencial que tem por objetivos verificar como os docentes têm selecionado e utilizado os recursos digitais em suas aulas; identificar como eles vêm criando e modificando os conteúdos necessários para o ensino; verificar como esses professores têm protegido os dados pessoais dos estudantes. Para coleta de dados utilizou-se o questionário online Check-In DigCompEdu, versão 2021 adaptada ao contexto do ensino superior brasileiro, o qual foi aplicado através da plataforma Limesurvey. Participaram deste estudo 224 professores. Como resultado, verificou-se que 28% dos participantes têm utilizado motores de busca e plataformas de internet e 27,5% têm avaliado e selecionado os recursos de acordo com a necessidade dos estudantes, porém, 2,2% dos professores indicaram não saber utilizar a Internet para pesquisa. 27,7% dos professores têm criado suas próprias apresentações digitais, mas dizem não saber fazer muito mais do que isso. 8,5% afirmaram não se preocupar com a proteção de dados pessoais, pois consideram que a universidade deve cuidar desta questão. Concluiu-se que é necessário aprimorar as habilidades dos docentes para utilizar os recursos digitais de forma mais eficaz e segura em suas atividades acadêmicas. Recomendamos que as bibliotecas universitárias desempenhem um papel mais efetivo no desenvolvimento de ações que promovam a competência digital dos professores.
Aprendizaje basado en problemas: una estrategia pedagógica para la enseñanza en las ciencias de la información y documentación
Authors: Pinheiro dos Santos Beatriz Rosa , Moro Cabero María Manuela , Damian Ieda Pelógia Martins
Published: November 2023

El presente artículo de investigación se enfoca en la búsqueda de estrategias pedagógicas para el aprendizaje de contenidos, competencias y habilidades en el Área científica de la información y documentación. Su objetivo principal es facilitar la adquisición de habilidades prácticas que promuevan la inserción laboral de los egresados. El estudio se centra en la convergencia entre la gestión del conocimiento y el aprendizaje activo, específicamente en el enfoque del Aprendizaje Basado en Problemas (ABP). La pregunta de investigación que se plantea es: ¿Cómo puede contribuir el ABP a una práctica pedagógica óptima en la enseñanza de ciencias de la información y documentación? Para alcanzar los objetivos propuestos, se lleva a cabo una metodología exploratoria-descriptiva, utilizando el análisis de datos según el enfoque de Bardin (2014). Los resultados principales resaltan que la aplicación del ABP en el campo de la información y documentación favorece la adquisición de habilidades prácticas y facilita la inserción laboral de los egresados. Además, se proporciona una base sólida para una práctica pedagógica óptima en el ámbito de las ciencias de la iInformación y documentación, al fomentar el desarrollo de competencias relevantes para el ejercicio profesional.
Desenvolvimento de um algoritmo para classificar obras infantis: abordagens a partir do pensamento computacional
Authors: Camillo Everton da Silva
Published: November 2023

O anseio para este estudo diz respeito à aproximação entre o processo de classificação em bibliotecas e o pensamento computacional, vertente teórica presente na ciência da computação e, mais atualmente, noutros domínios do conhecimento, como a ciência da informação. A pesquisa tem como objetivo apresentar um algoritmo para classificar obras da literatura infantil de modos preciso e computacional. Aplicou-se o método de pesquisa análise de conteúdo à tabela de classificação por cores presente no Guia de normalização das bibliotecas da rede de ensino de Vila Velha. Elaborou-se três categorias analíticas a posteriori com o auxílio da habilidade pensamento crítico. O resultado do estudo demonstrou três imprecisões na tabela de classificação por cores, sendo: mútua abrangência na classificação; incompatibilidade na relação gênero-espécie; incompatibilidade com a natureza da representação temática da informação. Assim, apresentou-se um algoritmo que possibilita classificar obras da literatura infantil de modos preciso e computacional. O estudo conclui que o pensamento computacional pode ser um processo organizador da atividade de classificação em bibliotecas, garantindo, portanto, a precisão na representação temática da informação devido ao caráter lógico-computacional amalgamado em todo o fluxo do processo.
ANÁLISE QUALI-QUANTITATIVA DA ARBORIZAÇÃO VIÁRIA DE DOIS BAIRROS DO MUNICÍPIO DE BAURU, SÃO PAULO
Authors: Gimenez Paula Letícia de Almeida , Siqueira Marcos Vinicius Bohrer Monteiro , Guerreiro Sidnei Fonseca , Sartori Anderson Antônio da Conceição
Published: November 2023

O desenvolvimento urbano e a preservação das áreas verdes devem ser trabalhadas em conjunto para a melhoria da qualidade de qualquer cidade. Este trabalho buscou avaliar a arborização viária de dois bairros da cidade de Bauru, São Paulo, por meio de um inventário arbóreo que considerou aspectos da fitossanidade, estado geral e interações ecológicas. No total foram inventariados 624 indivíduos, de 19 famílias e 34 espécies, sendo 201 indivíduos de origem exótica e 423 de origem nativa, onde cinco espécies foram responsáveis por 67,14% das árvores inventariadas. Licania tomentosa foi a espécie mais frequente, com 260 indivíduos do total inventariado, totalizando 41,66%. Quanto ao estado geral, a maioria das árvores apresentou bom estado (49,28%). Já na incidência de insetos, em 16,66% da arborização foi constatada a presença de formigas, e em 10,89%, de cupins. Tendo em vista que bioindicadores são espécies, grupos de espécies ou comunidades cuja presença, abundância e condições são indicativos biológicos de uma determinada condição ambiental, foi constatado que 26% das árvores continham epífitas e 62% líquens. Os resultados apresentaram um baixo índice de diversidade da flora no cenário urbano analisado. É necessário um melhor planejamento, com técnicas adequadas, e uma diversificação de espécies plantadas, sobretudo de espécies do bioma para melhoria da arborização urbana na região.
Innovative extraction technologies
Authors: Ilić Dušica P. , Vukotić Danica
Published: November 2023

The enormous biological potential of herbal products is one of the main reasons for their frequent use in the production of dietary supplements and functional foods, which, in addition to their nutritional properties, have pharmacological and physiological effects. New scientific knowledge on the isolation of pharmacologically active compounds from complex matrices has led to significant advances in this field. Today, the process of extraction plays a significant scientific role, with “green” technologies occupying a special place in today’s science. Herbal medicine is one of the oldest human skills, which has worn off with its centuries-old application in the path of modern medicine. Microwave-assisted extraction, or more simply, microwave extraction, is a new extraction technique that combines traditional extraction solvents and microwaves. The mentioned method takes less time, consumes less energy, and has strong penetration power into the plant matrix to obtain more oils, but it can also reduce production costs. This can eventually increase the quality of the final product and reduce the product price at the consumer level. Microwave-assisted extraction could be useful to the herbal industry for oil extraction as well as other pharmaceutically important plant components. Based on a comparison and study of published literature, this research examines the present state of extraction procedures. This review includes a detailed discussion of the most important extraction techniques.
Veterinary team members experiencing high levels of burden transfer are more likely to report burnout and a less optimal psychosocial work environment
Authors: Blokland Kirsten , Coe Jason B. , Spitznagel Mary Beth
Published: November 2023

OBJECTIVE

To describe burden transfer in a sample of veterinary workers employed by a Canadian veterinary corporation and to examine the association between different levels of burden transfer and employee burnout and perceived psychosocial work environment.

SAMPLE

475 employees of small-animal veterinary hospitals owned by a corporate practice group.

METHODS

Veterinary team members among 14 working groups responded to an online survey that included assessments of burden transfer, psychosocial environment, and burnout within the workplace. Participants were divided into groups on the basis of self-reported burden-transfer scores being low, mid, or high, and multivariate analysis of covariance was conducted to ascertain associations between level of burden transfer, psychosocial environment, and burnout.

RESULTS

On average, participants perceived difficult encounters with clients to occur with moderate frequency and reported reactions that were low-moderate in intensity. Individuals with high burden-transfer scores were identified in all working groups. Across the 3 burden-transfer groups, the key finding was that high-level burden transfer was associated with perception of greater emotional demands within the workplace, reduced support from supervisors, reduced feeling of social community in the workplace, and elevated rates of burnout among these participants.

CLINICAL RELEVANCE

Findings highlight elevated risks for a certain population of veterinary employees experiencing high levels of burden transfer and underscore the potential need for targeted interventions to support these individuals. Employees who currently react to challenging client interactions with moderate or low intensity may also benefit from these programs as a preventative measure.
Complex evaluation of wild pear
Authors: Gyurkó Adrienn , Baktay Borbála , Varga Anna , Szani Zsolt
Published: November 2023

The National Centre for Biodiversity and Gene Conservation (NBGK) started the gene bank collection and agrobotanical evaluation of wild pear varieties in 2022. The survey of individuals and the recording of descriptors was carried out in several rounds. Part of the data was recorded in situ on the field, and the other part was analysed after the trip. For the in-situ collection of wild fruit plant species and varieties, it was necessary to develop a method for the collection and description. This applied to the development of the survey methodology as well as to the design of the working method.
Monitoring of the water quality of Lake Blidinje and examination of the prognostic model
Authors: Ivanković Anita , Marić Marina , Petrović Danijela , Talić Stanislava , Martinović Bevanda Anita
Published: November 2023

The largest mountainous lake in Bosnia and Herzegovina, Lake Blidinje, is located 1,185 meters above sea level. Polymictic lakes are those in which the entire water column is frequently mixed. Shallow lakes function very differently than deep lakes in many ways because of the strong sediment– water interaction and the possibility for significant water impact on vegetation. In the multiple regression analysis, two models were developed with coefficients of multiple determination (R2 = 0.720 and R2 = 0.497) for the independent variable chlorophyll a. The resulting models are compared with water quality monitoring data from 2017 to 2019.
Causes and Consequences of Iranian Elite Athletes’ International Migrations
Authors: Salimi Mehdi , Khodaparast Mahboubeh , Nikou Parvaneh Savari
Published: November 2023

This study aimed to identify the causes and consequences of international migrations of Iranian elite athletes. This research was conducted using the qualitative method and Glaser grounded theory approach. The statistical population included senior managers in the Ministry of Sports and Youth and national sports federations, expert researchers in this field, professional athletes who have emigrated or were on the verge of emigration, and coaches in professional sports teams in Iran. Twenty-six people were selected through theoretical sampling and snowball methods. The data collection tool was a semi-structured individual interview. The Glaser approach was used to analyse the data, including two main stages of actual and theoretical coding. During the actual coding process, 468 primary statistical codes were identified, and 68 subcategories and 11 main categories were subsequently identified. The categories were divided into three general dimensions: “Factors affecting”, “Consequences”, and “Strategies” concerning “elite athletes’ emigration “; in the theoretical coding stage, the final model of the research was outlined. Identifying the causes and consequences of the emigration of elite athletes can significantly help the authorities to recognise problems in this area and provide appropriate solutions to retain adequate human capital in the country. We attempted to examine and present the causes and consequences of the emigration of Iranian elite athletes in the form of a model.
The Influence of Tilt on Berkovich Indentation of a Steel Sample Using FEM Analysis and Nanoindentation
Authors: Kovář Jaroslav , Fuis Vladimír , Čtvrtlík Radim , Tomáštík Jan
Published: November 2023

The main shape deviations of a Berkovich indenter are the indenter bluntness and indenter tilt. The influence of the Berkovich indenter tilt on the results of the FEM modelling of steel nanoindentation is evaluated in this paper. The indenter tilt has an impact on the indentation curves and contact area. The X5CrNiCuNb 16-4 steel nanoindentation was modelled by FEM and the indentation curves were obtained. The Berkovich indenter was blunted and the tilt of the indenter was changed to determine its influence on the indentation curves. The results showed that growing tilt shifts the indentation curves to higher values of indentation forces and makes unloading curves steeper which is in agreement with a larger contact area. The calculated indentation curves were compared with the experimental indentation curves and the impact of the indenter tilt to the indentation curves was determined.
Clinical features and outcomes in patients with human immunodeficiency virus-negative, Castleman’s disease: a single medical center study in Tunisia
Authors: Chabchoub Imen , Salah Raida Ben , Kallel Rim , Snoussi Mouna , Frikha Feten , Marzouk Sameh , Boudawara Tahya Sellami , Bahloul Zouhir
Published: November 2023

Introduction:

Castleman’s disease (CD), known as angiofollicular lymph node hyperplasia, is an uncommon condition. The two most common histological subtypes are hyaline vascular and plasma cell. We performed a retrospective analysis to define the clinic-pathological features and survival of CD, which is quite rare focusing on the particularities of our series with a review of the recent literature.

Methods:

This is a retrospective study conducted in the department of internal medicine of Hedi Chaker hospital in Sfax, Tunisia over 25 years. The disease was histologically confirmed in all patients. For each file, we collected a set of data by filling in a pre-designed form.

Results:

18 patients were included. There were 8 men and 10 women with a mean age of 42.8 years. CD was monocentric in 5 cases (28%) and multicentric in 13 cases (72%). Clinically, peripheral adenopathy was present in 77.7% of patients and deep adenopathy in 72.2%. Systemic signs were found in 13 patients, including general condition (4.4%), fever (16.6%), serositis (27.7%), and skin involvement (33.3%).

A biological inflammatory syndrome accompanied the clinical picture in 66% of patients. Abnormalities in the blood count were found in 12 cases (66%), with anemia in 11 cases, thrombocytosis in 3 cases, and hypereosinophilia in 3 cases.

Cutaneous Kaposi’s sarcoma was associated with Castleman’s disease in 2 cases, Hodgkin’s lymphoma, angioimmunoblastic T-cell lymphoma, and lymph node T-cell lymphoma were found in 1 case respectively. 3 of the patients had associated connective tissue diseases such as Sjögren’s syndrome in 2 cases and rheumatoid arthritis in 1 case. HHV8 serology was positive in 1 case with a multicentric plasma cell form.

Histologically, the plasma cell form represented 50% of cases, hyaline-vascular (39% of cases), and mixed (11% of cases).

Therapeutically, high-dose corticosteroid therapy was initiated in 13 cases. As a second-line treatment, MOPP chemotherapy was used in 1 case due to transformation into Hodgkin’s lymphoma, and biotherapy (rituximab) was used in 2 cases in the multicentric form. Surgical removal of superficial adenopathy was performed in 2 patients with monocentric CD.

Conclusion

: Castleman’s disease (CD) is a non-malignant lymphoproliferation of localized or multicentric form with a wide and heterogeneous clinical spectrum. Diagnosis can be difficult due to the lack of clinical and radiological specificity. Management depends on the clinical form involving surgical and/or medical management.
Corrosion Behavior and Mechanisms of Co-Cr-Mo Alloy Fabricated by Powder Metallurgy Route in Ringer's SolutionMuna
Authors: K. Abbass Muna , A. Yagoob Jawdat
Published: November 2023

The current research is aimed to study the corrosion behavior and mechanism of Co-Cr-Mo alloy fabricated by powder metallurgy route in Ringer's solution with 7.4 and 37oC for pH and temperature values, respectively.The research was done by using a potentiostat to obtain the potentiodynamic and cyclic polarization to measure and calculate some significant parameters of the alloy corrosion. The cyclic polarization curve is indicated the resistance of the fabricated samples to the pitting and crevice corrosions. Optical, SEM and SEM-Mapping observations were revealed that the corrosion of the tested alloy was due to inter-particle and inter granular corrosion.
Measurement of the Levels of Salivary Lipocalin-2 and C - reactive protein in Women with Polycystic Ovarian Syndrome
Authors: R. Sarhat Entedhar , A. Wadi Siham , R. Mahmood Ayhan , R. Sarhat Thuraia
Published: November 2023

The aim of the present study is to investigate salivary lipocalin-2 levels as well as C-reactive protein (CRP) in women with and without polycystic ovary syndrome (PCOS). Lipocalin-2 levels and C-reactive protein were measured in 104 women within the age group of (20 – 29) years were divided into two groups. Group I consisted of 55 diagnosed female patients of PCOS and Group II comprised of 49 female age matched control group with normal menstrual cycles. Highly significant differences were found using t-test in inter group comparison. Levels of lipocalin-2 in PCOS group were decreased significantly compared to the control group (p ˂ 0.05), while the salivary level of CRP were increased significantly in the PCOS group (p ˂ 0.05). Salivary levels of lipocalin-2 were found to be low whereas CRP were high among women with PCOS. It was suggested that the measurement of salivary lipocalin-2 and CRP may be specific method for making a diagnosis of women with polycystic ovary syndrome.
Identification of Candida Albicans Infection on Denture Wearing According to the Sex and Type of Denture Base Materials
Authors: Mohammed Alsewidi Wasan , H. Alfahdawi Ibrahim
Published: November 2023

Background: Oral Candidiasis is a wide opportunistic infection of the mouth due to an overgrowth of Candida species, the most being Candida albicans. Its harmless commensally organism inhabiting the mouth, but it will change into a pathogen, invade tissue, and cause acute and chronic diseases. The predisposing factor for infection with Candida was dentures in about sixty-five percentages of older peoples who are wearing full upper dentures. Objective: This research aims to determine the sex distribution of fungal infection in corresponding with fungal infection among groups (acrylic and metal denture base). Patients &Methods: Sixty-eight patients attend the private dental clinic were subjected to usual dental treatment. They were divided into two groups: group 1: included 43 (24 females and 19 males) with acrylic denture base wearers. As well as, group 2: metal denture base wearers in 25 (10 females and 15 males). Questionnaire Paper to determine demographic data include, if patient take any fungal or antibiotic or not (treated and non-treated) and would obtain from the patients by including sex, age, and nocturnal wear. Result: The results in this study found that the prime etiology of Candida growth was the prosthesis materials itself. Sixty-five percent of the wearers of dentures showed Candida growth, while thirty-five percent of patients who had their dentitions showed Candida growth that the appliances are the dominant etiological factors in the growth of Candida other local factors should be considered.
PINOS INTRARRADICULARES X ENDOCROWN: UMA REVISÃO DA LITERATURA
Authors: Paloma Wanessa Basílio dos Santos , Hugo Angelo Gomes de Oliveira
Published: November 2023

Endodontically treated teeth with substantial loss become elements more susceptible to fracture than vital teeth. Immediate esthetic and functional rehabilitations become necessary, with the estorative option being intraradicular retainers (RIR) and adhesive crowns (endocrown). The aim of the study is to carry out a literature review to compare the use of endocrown restorations with crowns with intraradicular pins relating their indications, effectiveness, advantages and disadvantages between the techniques. Searches were performed in the Virtual Health Library, Pubmed and Scielo databases, obtaining a total of 19 studies among systematic reviews, articles and course completion papers in Portuguese and English between 2007 and 2021. The use of endocrowns showed results satisfactory in all researched articles and the use of intraradicular pins may be considered as unnecessary
ALTERAÇÕES NA RUGOSIDADE SUPERFICIAL DAS CERÂMICAS ODONTOLÓGICAS PROVOCADAS PELO USO DE CLAREADORES DENTAIS
Authors: Letícia Silva das Virgens Queiroz , Alex Correia Vieira , Mario Cezar Silva de Oliveira , Adriana Castro Vieira Andrade
Published: November 2023

Whitening gels have been associated with several deleterious effects on teeth, oral mucosa and restorative materials, such as increased surface roughness of dental ceramics. The aim of this study was to review the current literature on the effects of bleaching gels on the surface roughness of ceramics. To this end, a search for scientific articles in the databases of the Virtual Health Library (VHL), PubMed, and Google Scholar was performed. Articles published in the last 11 years were selected, with full text available, written in Portuguese or English, and that included the determined descriptors. Several studies have brought controversial results when analyzing the correlation between bleaching agents and ceramic properties. These gels are highly oxidizing and release free radicals during the reaction, which may cause the leaching of alkaline ions and cause dissolution of the glass of the ceramic, compromising some of its properties, such as surface roughness. The increase in surface roughness is related to staining, decreased flexural strength, abrasion and wear of the antagonist teeth, and plaque aggregation. It can be concluded that there is still no consensus in the literature about the influence of bleaching agents on the surface roughness of ceramics.
Rare Case of Vasculitis Induced by Crusted Scabies Infection
Authors: Lyons Catherine , Luu Lydia , Martin Seth , Schenck Olivia
Published: November 2023

Here we present a 70-year-old man who presented with a rare case of cutaneous leukocytoclastic vasculitis (LCV) secondary to a crusted scabies (Sarcoptes scabiei var hominis) mite infestation. Few cases have been reported in the literature of LCV in association with scabies as LCV is typically caused by a bacterial or viral infection or other malignancy. Since this combination of cutaneous manifestations is rare, diagnosis and treatment may be delayed, allowing for the development of advanced disease.
Squamous Cell Carcinoma Arising in a Nevus Sebaceus in a 10-Year-Old Male
Authors: Porter Hannah , Lapides Rebecca , Morley Keith , Greene Laura , Ho Chin
Published: November 2023

The patient is a 10-year-old male who presented to a dermatologist regarding a bleeding plaque on the right scalp. The initial pathology report demonstrated an atypical endophytic squamous proliferation with an infiltrative pattern, raising concern for squamous cell carcinoma versus pseudoepitheliomatous hyperplasia. Physical exam showed a painless 4.4 x 1.2 cm elliptical, rough, orange-to-pink plaque with waxy superficial scale on the left forehead. Wide local excision was performed, and pathology confirmed no residual carcinoma. Squamous cell carcinoma arising in a nevus sebaceous in a pediatric patient is exceedingly rare, but as demonstrated by this case, does occur, emphasizing the need for improved guidelines for management to optimize treatment in the pediatric population.
Acquired Haemophilia A Associated with Bullous Pemphigoid
Authors: Evans Sophie , Moss Jake , Wainman Hannah
Published: November 2023

We would like to submit this manuscript for an image report entitled ‘Acquired haemophilia A associated with bullous pemphigoid’. We present the case of an 81-year-old female first investigated for a blistering dermatosis and diagnosed with bullous pemphigoid, who several weeks later developed extensive atraumatic ecchymosis with a grossly prolonged activated partial thromboplastin time consistent with acquired haemophilia. There is a known association between bullous pemphigoid and autoimmune haemophilia but less than 50 cases have been reported, and as such it remains rare. However, it is a potentially life-threatening complication of bullous pemphigoid and should be suspected in patients presenting with mucocutaneous bleeding. We describe the investigations leading to this diagnosis, summarise the management of acquired haemophilia, and illustrate the case with clinical photographs.
Mohs Appropriate Use Criteria Scores and Treatment of Keratinocyte Carcinoma: Review of 11,145 Tumors
Authors: Hope Richard H. , Dowdle Travis S. , Hope Landon , Pruneda Corley
Published: November 2023

Background: Various methods are available for treatment of keratinocyte carcinomas (KCs). The Mohs appropriate use criteria (AUC) score was developed to quantify the appropriateness of Mohs micrographic surgery (MMS) based on multiple tumor and patient characteristics. 
Objectives: Stratify KCs by treatment modality used and compare to Mohs AUC score.
Methods: Conducted a retrospective review of 11,145 consecutive KCs between 01/2017 and 12/2021, comparing associated Mohs AUC score with modality selected.
Results:  The average Mohs AUC score for all KCs combined was 7.1 with 8714 (78.2%) qualifying for MMS via AUC score. However, MMS was only done on 2813 (32.3%) of KCs. Excisional surgery was used to treat 4580 (41.1%) of KCs, 2777 (24.9%) were treated with electrodesiccation and curettage (ED&C), and 732 (6.6%) were treated with biopsy only. Of those KCs treated with excision, ED&C, or a biopsy, 70.7%, 70.7%, and 72.4% reached an “appropriate” Mohs AUC score for MMS respectively.
Limitations:  This is a single private practice, with two board certified dermatologists
Conclusions: Mohs AUC score can help determine if a KC warrants MMS; however, in our practice, MMS was necessary for only 32.3% of the KCs that qualified based on the Mohs AUC score.
Efficacy of Secukinumab in Patients With Mild to Moderate Psoriasis: A Pooled Analysis of 6 Phase 3 Studies
Authors: Strober Bruce , Van de Kerkhof Peter , Fan Heng , Levi Eugenia , Blauvelt Andrew
Published: November 2023

Introduction: Secukinumab has demonstrated sustained long-term efficacy for the treatment of patients with moderate to severe plaque psoriasis, but efficacy in mild to moderate psoriasis has not been rigorously evaluated. The secukinumab phase 3 clinical trial program included patients with mild to moderate psoriasis among populations with active psoriatic arthritis (EXCEED and FUTURE 2-5; NCT02745080, NCT01752634, NCT01989468, NCT02294227, and NCT02404350), and among patients with moderate to severe palmoplantar psoriasis (GESTURE; NCT01806597). Here, we report efficacy and safety of secukinumab in a pooled population of patients with mild to moderate psoriasis.

Methods: This post hoc analysis included patients from the phase 3 EXCEED, FUTURE 2-5, and GESTURE trials, with mild to moderate psoriasis defined as either a baseline affected body surface area (BSA) of 3%-10% or a baseline Investigator’s Global Assessment modified 2011 score (IGA) of 2 or 3. Patients were pooled by treatment received through Week 16 (treatment period 1) and from Weeks 16 to 52 (treatment period 2), according to the following groups: treatment period 1 (secukinumab 300 mg, secukinumab 150 mg, or placebo) and treatment period 2 (secukinumab 300 mg or secukinumab 150 mg). Efficacy was assessed by the proportion of patients achieving 75% improvement in the Psoriasis Area and Severity Index (PASI75), PASI90, and PASI100 among patients with a BSA 3%-10%; and by IGA 0/1 response with ≥2-point improvement among patients with baseline IGA score of 2 or 3. Descriptive statistics were reported for each outcome. Missing data were imputed using non-responder imputation.

Results: Overall, 654 patients and 971 patients had mild to moderate psoriasis at baseline as defined by a BSA of 3%-10% or IGA score of 2 or 3, respectively. Demographics and baseline disease characteristics were similar between populations defined by BSA and by IGA. Among patients with a baseline BSA of 3%-10%, secukinumab resulted in greater achievement of PASI75/90/100 vs placebo at Week 12 (secukinumab 300 mg: 62.8%/44.4%/33.1%; secukinumab 150 mg: 48.0%/29.1%/19.4%; placebo: 11.7%/9.0%/8.0%), with increased responses at Week 52 (secukinumab 300 mg: 65.7%/56.5%/47.3%; secukinumab 150 mg: 58.1%/40.5%/31.3%). The proportion of patients with baseline IGA=2 or 3 achieving IGA 0/1 response with ≥2-point improvement was greater among patients receiving secukinumab 300 mg (46.6%) or 150 mg (37.2%) than placebo (8.6%) at Week 12, with increased responses at Week 52 (secukinumab 300 mg: 52.5%; secukinumab 150 mg: 44.4%).

Conclusions: Secukinumab led to improvements in measures of disease severity among patients with mild to moderate psoriasis after 12 weeks of treatment vs placebo in a pooled analysis of patients with psoriatic arthritis or palmoplantar psoriasis. Both doses of secukinumab showed increased efficacy from Week 12 to Week 52.
Time to Onset of a Minimal Clinically Important Difference in DLQI with Guselkumab Treatment in VOYAGE 1
Authors: Abbarin Nastaran , Papp Kim , Langley Richard , Adam David , Ho Vincent , Park-Wyllie Laura , Miller Megan , You Yin , Yang Ya-Wen , Gooderham Melinda
Published: November 2023

Introduction Psoriasis (PsO) is a chronic inflammatory disease of the skin. While skin clearance, as measured by the Psoriasis Area and Severity Index (PASI), is a clinical goal, PsO patients also suffer from reduced health-related quality of life (HRQoL). In the Phase 3 VOYAGE 1 trial, guselkumab (GUS) demonstrated improvements on patient reported outcomes compared with placebo (PBO) and adalimumab (ADA). Here we report an analysis of the estimated time to onset of the minimal clinically important difference (MCID) in HRQoL, as measured by the Dermatology Quality of Life Index (DLQI) and associated PASI response in GUS-treated patients from VOYAGE 1.

Methods The VOYAGE 1 trial enrolled patients with moderate-to-severe PsO who were randomized to receive PBO, GUS, or ADA. The DLQI is a self-report measure for HRQoL ranging from 0 (no impact) to 30 (maximum impact) that assesses the effect of skin problems on 6 HRQoL domains. An accepted MCID in DLQI is 4, previously reported as the smallest difference in DLQI total score that patients’ rate as beneficial. DLQI score and PASI improvement (percent change from baseline) were analyzed at Weeks 0, 8, 16, and 24 for the subset of VOYAGE 1 patients with a baseline DLQI score >4. Earliest time to onset of MCID in mean DLQI and corresponding mean PASI improvement were estimated using linear interpolation for the GUS group between Weeks 0 and 8.

Results Among patients randomized to GUS, n=279 (85%) had DLQI >4 at baseline. By first assessment at Week 8 (W8), we observed a reduction in the mean DLQI score from 15.6 (baseline) to 5.0 (W8) with median DLQI decreasing from 15.0 (baseline) to 3.0 (W8). The interpolated onset of MCID in DLQI occurred at 21.1 days (W3) following the initial GUS dose. In GUS-treated patients, the estimated mean PASI improvement corresponding to the onset of MCID in mean DLQI occurring at Week 3 was 29.2%.

Conclusions These data indicate that the onset of clinically meaningful improvements in mean DLQI occur as early as after the first dose of GUS in patients with moderate-to-severe PsO.
A Phase 3b Study Evaluating Safety and Efficacy of Risankizumab in Adult Patients with Moderate-to-Severe Plaque Psoriasis with Palmoplantar (Non-Pustular) Involvement
Authors: Lebwohl Mark , Bukhalo Michael , Gold Linda Stein , Pelle Michelle , Glick Bradley , Llamas-Velasco Mar , Sanchez-Rivera Samuel , Zhan Tianyu , Drogaris Leonidas , Douglas Kevin , St. John Greg , Espaillat Ramon , Bissonnette Robert
Published: November 2023

Introduction: We evaluate safety and efficacy of risankizumab (RZB) vs. placebo (PBO) in adult patients with moderate-to-severe non-pustular palmoplantar psoriasis (PPPsO).

Method: IMMprint, a Ph3b study evaluated safety and efficacy of RZB vs. PBO in moderate-to-severe PPPsO patients with a static physician’s global assessment(sPGA) of moderate or severe ≥3, palmoplantar psoriasis area and severity index(PPASI) ≥8 and at least 1 additional PsO plaque. The 52-week treatment was split into period A, patients randomized (1:1) to RZB 150-mg or PBO, and period B, patients continuing RZB or switching from PBO to RZB (PBO/RZB). Primary endpoint was achievement of palmoplantar investigator’s global assessment (ppIGA) 0/1 with at least 2-point reduction from baseline at Wk16. Ranked secondary endpoints include ≥75% & 90% improvement in PPASI (PPASI75, PPASI90), sPGA 0/1 and 100% improvement in PPASI(PPASI100) at Wk16.

Results: Of 174 enrolled, 87(mean age[SD]: 56.9[12.9] years) were randomized to RZB and 87(mean age[SD]: 53.9[14.3] years) were randomized to PBO. Baseline characteristics were similar except for numerical difference in PsA (RZB vs. PBO: 11.5% vs 4.6%, respectively). At Wk16, a significantly higher proportion receiving RZB achieved ppIGA 0/1 than PBO(33.3% vs. 16.1%, p = 0.006). Patients receiving RZB also demonstrated significantly higher responses than patients receiving PBO in all ranked secondary endpoints: PPASI75 (42.5% vs 14.9%, P < 0.001); PPASI90 (27.6% vs 5.7%, p<0.001); sPGA 0/1 (32.2% vs 11.5%, p < 0.001); and PPASI100 (17.2% vs. 1.1%, p < 0.001). Four patients (3 RZB: 1 PBO) discontinued drug in period A. At Wk52, ppIGA 0/1 was achieved by 50.6% of RZB patients and 61.7% of PBO/RZB group. Proportion of patients achieving PPASI75 at Wk52 was 57.5%(RZB) vs. 65.4% (PBO/RZB). Achievement of sPGA 0/1 (%RZB vs. %PBO/RZB) was 43.7% vs. 66.7%; PPASI100 was achieved by 26.4% (RZB) and 37.0% (PBO/RZB) patients at Wk52. Proportion of patients with adverse events were 29.1%(RZB) and 23.0%(PBO) in period A, and 49.4%(RZB) and 35.8% (PBO/RZB) in period B. One RZB patient with prior cardiovascular risk factors had an adjudicated myocardial infarction and subsequently died after 140-day follow-up period.  The number of patients with COVID-19 were 3 (RZB; 1 serious infection) and 2(PBO) in period A and 11 (RZB) and 7 (PBO/RZB) in period B.

Conclusion: This study demonstrates RZB can provide effective improvement compared to PBO by Wk16 with continuous improvement until Wk52 with no new safety signals in patients with moderate-to-severe PPPsO.