bluuebunny/crossref_metadata_2025 huggingface dataset:
The Pd (II) Reduction Mechanisms in Bacillus megaterium Y-4 Revealed by Proteomic Analysis
Authors: Chen Yuan , Wang Jiaxing , Chen Daidi , Wang Boxi , Wu Jinchuan , Liu Rongrong , Li Qingxin
Published: March 2024

Many studies have been conducted on the microbial reduction of Pd (II) to palladium nanoparticles (Pd-NPs) due to the environmental friendliness, low cost, and the decreased toxicity of Pd (II) ions. In this study, we investigate the reduction mechanism of Pd (II) by Bacillus megaterium Y-4 through proteomics. The data are available via ProteomeXchange with identifier PXD049711. Our results revealed that B. megaterium Y-4 may use the endogenous electron donor (NAD(P)H) generated by nirB, tdh, and fabG and reductase to reduce Pd (II) to Pd-NPs. The expression levels of fabG, tdh, gudB, and rocG that generate NAD(P)H were further increased, and the number of reduced Pd-NPs was further increased with the exogenous electron donor sodium formate. Endogenous electron mediators such as quinones and flavins in B. megaterium Y-4 can further enhance Pd (II) reduction. The findings provided invaluable information regarding the reduction mechanism of Pd (II) by B. megaterium Y-4 at the proteome level.
Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer
Authors: Marino Pasquale , Mininni Mariangela , Deiana Giovanni , Marino Graziella , Divella Rosa , Bochicchio Ilaria , Giuliano Alda , Lapadula Stefania , Lettini Alessandro Rocco , Sanseverino Francesca
Published: March 2024

Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence has increased over the years. A potential strategy to counter the growing spread of various forms of cancer is the adoption of prevention strategies, in particular, the use of healthy lifestyles, such as maintaining a healthy weight, following a healthy diet; being physically active; avoiding smoking, alcohol consumption, and sun exposure; and vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing to its development, progression, and severity. This review evaluates the relationship between potentially modifiable risk factors and overall cancer development, specifically breast, colorectal, and prostate cancer, and highlights updated recommendations on cancer prevention. The results of numerous clinical and epidemiological studies clearly show the influence of lifestyles on the development and prevention of cancer. An incorrect diet, composed mainly of saturated fats and processed products, resulting in increased body weight, combined with physical inactivity, alcohol consumption, and smoking, has induced an increase in the incidence of all three types of cancer under study. Given the importance of adopting correct and healthy lifestyles to prevent cancer, global institutions should develop strategies and environments that encourage individuals to adopt healthy and regular behaviors.
Urban–Rural Differences in School Districts’ Local Wellness Policies and Policy Implementation Environments
Authors: Iyer Swati , Walker Timothy J. , MacMillan Uribe Alexandra L. , Rethorst Chad D. , Seguin-Fowler Rebecca A. , Szeszulski Jacob
Published: March 2024

Higher rates of obesity in rural compared to urban districts suggest environmental differences that affect student health. This study examined urban–rural differences in districts’ local wellness policies (LWPs) and LWP implementation environments. Cross-sectional data from two assessments in Texas were analyzed. In assessment one, each district’s LWP was reviewed to see if 16 goals were included. In assessment two, an audit was conducted to identify the presence of a wellness plan (a document with recommendations for implementing LWPs), triennial LWP assessment, and school health advisory councils (SHACs) on the district website. Rural districts’ LWPs had a smaller number of total goals (B = −2.281, p = 0.014), nutrition education goals (B = −0.654, p = 0.005), and other school-based activity goals (B = −0.675, p = 0.001) in their LWPs, compared to urban districts. Rural districts also had lower odds of having a wellness plan (OR = 0.520, 95% CI = 0.288–0.939), p = 0.030) and a SHAC (OR = 0.201, 95% CI = 0.113–0.357, p < 0.001) to support LWP implementation, compared to urban districts. More resources may be needed to create effective SHACs that can help develop and implement LWPs in rural areas. Important urban–rural differences exist in Texas LWPs and LWP implementation environments.
A Cross-Sectional Quantitative Metabolomics Study Evidencing the Metabolic Signature in Six Organs during a 14-Week High-Fat High-Sucrose and Standard Diet in Mice
Authors: Drevet Mulard Eva , Guibert Sylvie , Mey Anne , Lefevre Camille , Chauvin Marie-Agnès , Pinteur Claudie , Monet Marie-Ambre , Godet Murielle , Madec Anne-Marie , Morio Béatrice , Rieusset Jennifer , Rautureau Gilles J. P. , Panthu Baptiste
Published: March 2024

Obesity is a risk factor for many diseases, such as type 2 diabetes and cardiovascular diseases. In line with the need for precision medicine, the search for biomarkers reporting the progression of obesity- and diet-associated disorders is urgent. We used NMR to determine the metabolomics profile of key organs (lung, liver, heart, skeletal muscle, kidney, and brain) and serum from male C57Bl/6J mice (5 weeks old) fed for 6, 10, and 14 weeks on a high-fat and high-sucrose diet (HFHSD) vs. a standard diet (STD). We determined metabolite concentrations in the organs at each time point, which allowed us to discriminate age- and diet-related effects as well as the interactions between both, highlighting the need to evaluate the influence of age as a confounding factor on metabolic signatures. Notably, the analysis revealed the influence of time on metabolite concentrations in the STD condition, probably reflecting the juvenile-to-adult transition. Variations impacted the liver and lung metabolites, revealing the strong influence of the HFHS diet on normal metabolism maturation during youth.
Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness
Authors: Vafaei Somayeh , Alkhrait Samar , Yang Qiwei , Ali Mohamed , Al-Hendy Ayman
Published: March 2024

Uterine fibroids (UFs) are the most common prevalent benign tumor among women of reproductive age, disproportionately affecting women of color. This paper introduces an innovative management strategy for UFs, emphasizing the curbing of disease prevention and progression. Traditionally, medical intervention is deferred until advanced stages, necessitating invasive surgeries such as hysterectomy or myomectomy, leading to high recurrence rates and increased healthcare costs. The strategy, outlined in this review, emphasizes UF disease management and is named LIFE UP awareness—standing for Lifestyle Interventions, Food Modifications, and Environmental Practices for UF Prevention. These cost-effective, safe, and accessible measures hold the potential to prevent UFs, improve overall reproductive health, reduce the need for invasive procedures, and generate substantial cost savings for both individuals and healthcare systems. This review underscores the importance of a proactive UF management method, paving the way for future research and policy initiatives in this domain.
Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice
Authors: Lee Seung-Hyeon , Choi Jiwon , Park Jae Young , Kim Ha-Rim , Shim Myeongkuk , Im Kyunghyun , Choe Hyeonjeong , Choi Jae-Chul , Park Young-Chul , Lim Tae-Gyu , Seo Hyangyim , Jang Hansu , Oh Boung-Jun , Kim Seon-Young , Park Mi Hee
Published: March 2024

The purpose of this work was to examine the effects of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting of 60% of total calories for 12 weeks. PGA-K administration reduced the increase in body weight, epididymal fat, and liver weight caused by a high-fat diet compared to the obese group. The triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels, which are blood lipid indicators, were significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. The administration of PGA-K resulted in a significant inhibition of pro-inflammatory cytokines, including tumor necrosis factor α and interleukin 6. Moreover, the levels of leptin and insulin, which are insulin resistance indicators, significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. These results suggest that PGA-K exhibits a protective effect against obesity induced by a high-fat diet, underscoring its potential as a candidate for obesity treatment.
Niosomal Bupropion: Exploring Therapeutic Frontiers through Behavioral Profiling
Authors: Harini Karthick , Alomar Suliman Yousef , Vajagathali Mohammed , Manoharadas Salim , Thirumalai Anbazhagan , Girigoswami Koyeli , Girigoswami Agnishwar
Published: March 2024

Bupropion (Bup) belongs to the norepinephrine–dopamine reuptake inhibitor (NDRI) class and it is the only FDA-approved drug of its class for the treatment of major depressive disorder (MDD), sold under the name of Wellbutrin. Although bupropion is effective in suppressing the symptoms, its regular use and overdose might lead to seizures and liver failure. Thus, we aimed to nanoformulate bupropion onto a niosomal vesicle to improve its efficacy and achieve the same therapeutic effect at lower scheduled doses. A thin film hydration method was adopted to synthesize and optimize Bup entrapped niosomes using three different surfactants of the sorbitan ester series (Span 20, 40, and 60) in combination with cholesterol. The optimization data determined that the niosome formulated with a cholesterol-to-surfactant ratio of 1:1.5 is the most stable system, with the Bup entrapped niosomes containing Span 20 (Bup@N20C) exhibiting minimal in vitro and in vivo toxicity, and demonstrating the sustained release of Bup in artificial cerebrospinal fluid (ACSF). The Bup@N20C formulation showed increased exploration activity and reduced irregular movements in reserpine-induced depression in the adult zebrafish model, suggesting the potential for mood improvement through the suppression of depression-like behavior which was established by statistical analysis and trajectory data. The Bup@N20C-treated group even surpasses the treatment effect of the positive control group and is comparable to the control group. Hence, it can be inferred that niosomal formulations of Bup represent a promising delivery system capable of achieving the brain delivery of the cargo by bypassing the blood–brain barrier facilitated by their small architectural structure.
Efficacy Analysis and Prognostic Impact of Sivelestat Sodium in Coronavirus Disease 2019-Related Acute Respiratory Distress Syndrome
Authors: Che Xiao , Hu Wei , Zhang Ziying , Wang Lexiao , Xu Zhe , Wang Fusheng
Published: March 2024

Purpose: This study aimed to evaluate the efficacy of sivelestat sodium on mortality, oxygenation index, and serum markers in patients with acute respiratory distress syndrome (ARDS) associated with Coronavirus Disease 2019 (COVID-19). Methods: A retrospective analysis was conducted on adult inpatients admitted to the Intensive Care Unit (ICU). The study compared clinical characteristics, laboratory indices, and mortality rates between patients treated with and without sivelestat sodium. Cox regression analysis was employed to assess the effect of sivelestat sodium on the risk of death, oxygenation index, and improvement of serum markers in patients with COVID-19-associated ARDS. Results: A total of 110 patients with COVID-19-associated ARDS were included, with 45 patients in the sivelestat group and 65 patients in the control group. The overall patient mortality rate was 69.1%, with 62.2% in the sivelestat group and 73.8% in the control group. After five days of treatment, the median change from baseline in the oxygenation index was 21 mmHg in the medicated group and −31 mmHg in the control group (p < 0.05). Analysis of the oxygenation index as a clinical endpoint event showed a significantly higher rate of improvement in the sivelestat group compared to the control group (57.8% vs. 38.5%, p < 0.05), and the odds of raising the oxygenation index after treatment were 2.05 times higher in the sivelestat group than in the control group (HR = 2.05, 95%CI: 1.02–4.15, p < 0.05). Among patients with a baseline oxygenation index < 200 mmHg, patients in the sivelestat group had an 86% lower risk of death compared to the control group (HR = 0.14, 95%CI: 0.02–0.81, p < 0.05). Conclusions: Sivelestat sodium demonstrated a significant improvement in the oxygenation index of patients with COVID-19-associated ARDS and was found to considerably reduce the risk of death in patients with a baseline oxygenation index of <200 mmHg.
Pioneering Arterial Hypertension Phenotyping on Nationally Aggregated Electronic Health Records
Authors: Neo Jing Wei , Xie Qihuang , Ang Pei San , Tan Hui Xing , Foo Belinda , Koon Yen Ling , Ng Amelia , Tan Siew Har , Teo Desmond , Tham Mun Yee , Yap Aaron , Ng Nicholas , Loke Celine Wei Ping , Peck Li Fung , Huang Huilin , Dorajoo Sreemanee Raaj
Published: March 2024

Background: Hypertension is frequently studied in epidemiological studies that have been conducted using retrospective observational data, either as an outcome or a variable. However, there are few validation studies investigating the accuracy of hypertension phenotyping algorithms in aggregated electronic health record (EHR) data. Methods: Utilizing a centralized repository of inpatient EHR data from Singapore for the period of 2019–2020, a new algorithm that incorporates both diagnostic codes and medication details (Diag+Med) was devised. This algorithm was intended to supplement and improve the diagnostic code-only model (Diag-Only) for the classification of hypertension. We computed various metrics (sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV)) to assess the algorithm’s effectiveness in identifying hypertension on 2813 chart-reviewed records. This pool was composed of two patient cohorts: a random sampling of all inpatient admissions (Random Cohort) and a targeted group with atrial fibrillation diagnoses (AF Cohort). Results: The Diag+Med algorithm was more sensitive at detecting hypertension patients in both cohorts compared to the Diag-Only algorithm (83.8 and 87.6% vs. 68.2 and 66.5% in the Random and AF Cohorts, respectively). These improvements in sensitivity came at minimal costs in terms of PPV reductions (88.2 and 90.3% vs. 91.4 and 94.2%, respectively). Conclusion: The combined use of diagnosis codes and specific antihypertension medication exposure patterns facilitates a more accurate capture of patients with hypertension in a database of aggregated EHRs from diverse healthcare institutions in Singapore. The results presented here allow for the bias correction of risk estimates derived from observational studies involving hypertension.
Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations
Authors: Becker Tim , Heitkötter Jan , Krome Anna K. , Schiefer Andrea , Pfarr Kenneth , Ehrens Alexandra , Grosse Miriam , Sandargo Birthe , Stammberger Ingo , Stadler Marc , Hübner Marc P. , Kehraus Stefan , Hoerauf Achim , Wagner Karl G.
Published: March 2024

Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle screening for oral administration since non-aqueous solvents are often not tolerable. In the case of the anti-infective corallopyronin A, currently undergoing preclinical investigation for filarial nematode and bacterial infections, commonly used vehicles such as polyethylene glycol 200, aqueous solutions combined with cosolvents or solubilizers, or aqueous suspension have failed due to insufficient tolerability, solubility, or the generation of a non-homogeneous suspension. To this end, the aim of the study was to establish an alternative approach which offers suitable tolerability, dissolution, and ease of handling. Thus, a corallopyronin A-mesoporous silica formulation was successfully processed and tested in a seven-day toxicology study focused on Beagle dogs, including a toxicokinetic investigation on day one. Sufficient tolerability was confirmed by the vehicle control group. The vehicle enabled high-dose levels resulting in a low-, middle-, and high-dose of 150, 450, and 750 mg/kg. Overall, it was possible to achieve high plasma concentrations and exposures, leading to a valuable outcome of the toxicology study and establishing mesoporous silica as a valuable contender for challenging drug candidates.
Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide
Authors: Matteo Cristina , Orienti Isabella , Eramo Adriana , Zeuner Ann , Ferrari Mariella , Passoni Alice , Bagnati Renzo , Ponzo Marianna , Bello Ezia , Zucchetti Massimo , Frapolli Roberta
Published: March 2024

We describe the development and validation of a HPLC-MS/MS method to assess the pharmacokinetics and tumor distribution of fenretinide, a synthetic retinoid chemically related to all-trans-retinoic acid, after administration of a novel oral nanoformulation of fenretinide, called bionanofenretinide (BNF). BNF was developed to overcome the major limitation of fenretinide: its poor aqueous solubility and bioavailability due to its hydrophobic nature. The method proved to be reproducible, precise and highly accurate for the measurement of the drug and the main metabolites. The lower limit of quantification resulted in 1 ng/mL. The curve range of 1–500 ng/mL and 50–2000 ng/mL, for plasma and tumor homogenate, respectively, was appropriate for the analysis, as demonstrated by the accuracy of between 96.8% and 102.4% for plasma and 96.6 to 102.3% for the tumor. The interdays precision and accuracy determined on quality controls at three different levels were in the ranges of 6.9 to 7.5% and 99.3 to 101.0%, and 0.96 to 1.91% and 102.3 to 105.8% for plasma and tumor, respectively. With the application of the novel assay in explorative pharmacokinetic studies, following acute and chronic oral administration of the nanoformulation, fenretinide was detected in plasma and tumor tissue at a concentration higher than the IC50 value necessary for in vitro inhibitory activity (i.e., 1–5 µM) in different cancer cells lines. We were also able to detect the presence in plasma and tumor of active and inactive metabolites of fenretinide.
Polypharmacy Is Associated with Sociodemographic Factors and Socioeconomic Status in United States Adults
Authors: Vennu Vishal
Published: March 2024

A thorough understanding of polypharmacy is required to create public health initiatives that minimize the potential for adverse outcomes. This study aimed to investigate the relationship between sociodemographic factors, socioeconomic status (SES), and polypharmacy risk in United States (US) individuals between 1999–2000 and 2017–2018. The cross-sectional National Health and Nutrition Examination Survey dataset covered ten cycles between 1999–2000 and 2017–2018. All individuals aged ≥18 years were included. The simultaneous use of at least five medications by one person is known as polypharmacy. Multivariable logistic regression showed that there was a statistically significant association between polypharmacy sociodemographic factors (such as age between 45 and 64 (odds ratio [OR] = 3.76; 95% confidence interval [CI] = 3.60–3.92; p < 0.0001) and age of 65 years or above (OR = 3.96; 95% CI = 3.79–4.13; p < 0.0001), especially women (OR = 1.09; 95% CI = 1.06–1.13; p < 0.0001), non-Hispanic blacks (OR = 1.66; 95% CI = 1.51–1.83; p < 0.0001), and veterans (OR = 1.27; 95% CI = 1.22–1.31; p < 0.0001)) and SES (such as being married (OR = 1.14; 95% CI = 1.08–1.19; p = 0.031), widowed, divorced, or separated (OR = 1.21; 95% CI = 1.15–1.26; p < 0.0001), a college graduate or above (OR = 1.21, 95% CI = 1.15–1.27, p < 0.0001), and earning > USD 55,000 per year (OR = 1.86; 95% CI = 1.79–1.93; p < 0.0001)). Individuals aged 45 years and above, women, and non-Hispanic blacks with higher educational levels and yearly incomes were more likely to experience polypharmacy in the US between 1999–2000 and 2017–2018.
The Evaluation of a Long-Term Experiment on the Relationships between Weather, Nitrogen Fertilization, Preceding Crop, and Winter Wheat Grain Yield on Cambisol
Authors: Hlisnikovský Lukáš , Menšík Ladislav , Roman Muhammad , Kunzová Eva
Published: March 2024

In this paper, a sequence (1979–2022) of a long-term trial established in Lukavec in 1956 (Czech Republic) focusing on the effect of weather, various nitrogen (N) fertilization methods (control, PK, N1PK, N2PK, and N3PK) and preceding crops (cereals, legumes, and oil plants) on winter wheat grain yield is presented. The weather significantly changed at the site of the long-term trial. While the trend in the mean temperature significantly increased, precipitation did not change significantly over the long term. Four relationships between weather and grain yield were evaluated to be significant: (a) the mean temperature in February (r = −0.4) and the precipitation in (b) February (r = −0.4), (c) March (r = −0.4), and (d) May (r = 0.5). The yield trends for all the fertilizer treatments increased, including the unfertilized control. The N3PK treatment provided the highest mean grain yields, while the unfertilized control had the lowest yields. Comparing the preceding crops, the highest yields were harvested when the wheat followed the legumes. On the other hand, the cereals were evaluated as the least suitable preceding crop in terms of grain yield. According to the linear-plateau model, the optimal nitrogen (N) dose for modern wheat varieties, following legumes and under the trial’s soil climate conditions, was 131 kg ha−1 N, corresponding to a mean grain yield of 8.2 t ha−1.
Diversity of Leaf Fungal Endophytes from Two Coffea arabica Varieties and Antagonism towards Coffee Leaf Rust
Authors: Poma-Angamarca Ruth A. , Rojas Jacqueline R. , Sánchez-Rodríguez Aminael , Ruiz-González Mario X.
Published: March 2024

Coffee has immense value as a worldwide-appreciated commodity. However, its production faces the effects of climate change and the spread of severe diseases such as coffee leaf rust (CLR). The exploration of fungal endophytes associated with Coffea sp. has already found the existence of nearly 600 fungal species, but their role in the plants remains practically unknown. We have researched the diversity of leaf fungal endophytes in two Coffea arabica varieties: one susceptible and one resistant to CLR. Then, we conducted cross-infection essays with four common endophyte species (three Colletotrichum sp. and Xylaria sp. 1) and Hemileia vastatrix (CLR) in leaf discs, to investigate the interaction of the endophytes on CLR colonisation success and severity of infection. Two Colletotrichum sp., when inoculated 72 h before H. vastatrix, prevented the colonisation of the leaf disc by the latter. Moreover, the presence of endophytes prior to the arrival of H. vastatrix ameliorated the severity of CLR. Our work highlights both the importance of characterising the hidden biodiversity of endophytes and investigating their potential roles in the plant-endophyte interaction.
Nutritional Characterization of Chilean Landraces of Common Bean
Authors: Márquez Katherine , Arriagada Osvin , Pérez-Díaz Ricardo , Cabeza Ricardo A. , Plaza Andrea , Arévalo Bárbara , Meisel Lee A. , Ojeda Daniela , Silva Herman , Schwember Andrés R. , Fuentes Camila , Flores Mónica , Carrasco Basilio
Published: March 2024

Common bean (Phaseolus vulgaris L.) is the primary grain legume cultivated worldwide for direct human consumption due to the high nutritional value of its seeds and pods. The high protein content of common beans highlights it as the most promising source of plant-based protein for the food industry. Additionally, landraces of common bean have great variability in nutritional traits, which is necessary to increase the nutritional quality of elite varieties. Therefore, the main objective of this study was to nutritionally characterize 23 Chilean landraces and 5 commercial varieties of common bean to identify genotypes with high nutritional value that are promising for the food industry and for genetic improvement programs. The landrace Phv23 (‘Palo’) was the most outstanding with high concentrations of minerals such as P (7.53 g/kg), K (19.8 g/kg), Mg (2.43 g/kg), Zn (52.67 mg/kg), and Cu (13.67 mg/kg); essential amino acids (364.8 mg/g protein); and total proteins (30.35 g/100 g seed). Additionally, the landraces Phv9 (‘Cimarrón’), Phv17 (‘Juanita’), Phv3 (‘Araucano’), Phv8 (‘Cabrita/Señorita’), and Phv4 (‘Arroz’) had a high protein content. The landrace Phv24 (‘Peumo’) stood out for its phenolic compounds (TPC = 218.1 mg GA/100 g seed) and antioxidant activity (ORAC = 22,167.9 μmol eq trolox/100 g extract), but it has moderate to low mineral and protein concentrations. In general, the concentration of nutritional compounds in some Chilean landraces was significantly different from the commercial varieties, highlighting their high nutritional value and their potential use for the food industry and for genetic improvement purposes.
Development and Characterization of a Natural Antioxidant Additive in Powder Based on Polyphenols Extracted from Agro-Industrial Wastes (Walnut Green Husk): Effect of Chickpea Protein Concentration as an Encapsulating Agent during Storage
Authors: Soto-Madrid Daniela , Arrau Florencia , Zúñiga Rommy N. , Gutiérrez-Cutiño Marlén , Matiacevich Silvia
Published: March 2024

Developing a powder-form natural antioxidant additive involves utilizing polyphenols extracted from agro-industrial wastes (walnut green husk). This research explores chickpea proteins (CPP) as an emergent encapsulating agent to enhance the stability and shelf life of the antioxidant additive. This study aims to develop a natural antioxidant powder additive based on polyphenols obtained from walnut green husks encapsulated by chickpea protein (5%, 7.5%, and 10% w/v) to evaluate their effect under storage at relative humidities (33 and 75% RH). The physicochemical and structural properties analysis indicated that better results were obtained by increasing the protein concentration. This demonstrates the protective effect of CPP on the phenolic compounds and that it is potentially non-toxic. The results suggest that the optimal conditions for storing the antioxidant powder, focusing on antioxidant activity and powder color, involve low relative humidities (33%) and high protein concentration (10%). This research will contribute to demonstrating chickpea protein as an emerging encapsulating agent and the importance of the cytotoxic analysis of extracts obtained from agroindustrial wastes.
Non-Woven Fabric Thermal-Conductive Triboelectric Nanogenerator via Compositing Zirconium Boride
Authors: Wang Xin , Liu Jinming , Chen Haiming , Zhou Shihao , Mao Dongsheng
Published: March 2024

With the vigorous development of the Internet of Things, 5G technology, and artificial intelligence, flexible wearable sensors have received great attention. As a simple and low-cost power supply in wearable sensors, the triboelectric nanogenerator (TENG) has a wide range of applications in the field of flexible electronics. However, most polymers are thermally poor conductors (less than 0.1 W/(m·K)), resulting in insufficient heat dissipation performance and limiting the development of TENG. In this study, a high-performance non-woven fabric TENG with strong thermal conductivity (0.26 W/m·K) was achieved by introducing ZrB2 into the polyurethane (PU) matrix. The excellent output performance with an open circuit voltage (Voc) of 347.6 V, a short circuit current (Isc) of 3.61 μA, and an accumulated charge of 142.4 nC endows it with good sensitivity. The electrospun PU/ZrB2 composites exhibit excellent sensing performance to detect body movements in situ, such as pressing, clapping, running, and walking. Moreover, the generated power can light up 224 LED bulbs as a demonstration of self-powering ability.
Study of the Failure Mechanism of a High-Density Polyethylene Liner in a Type IV High-Pressure Storage Tank
Authors: Rondinella Alfredo , Capurso Giovanni , Zanocco Matteo , Basso Federico , Calligaro Chiara , Menotti Davide , Agnoletti Alberto , Fedrizzi Lorenzo
Published: March 2024

The use of Type IV cylinders for gas storage is becoming more widespread in various sectors, especially in transportation, owing to the lightweight nature of this type of cylinder, which is composed of a polymeric liner that exerts a barrier effect and an outer composite material shell that primarily imparts mechanical strength. In this work, the failure analysis of an HDPE liner in a Type IV cylinder for high-pressure storage was carried out. The breakdown occurred during a cyclic pressure test at room temperature and manifested in the hemispherical head area, as cracks perpendicular to the liner pinch-off line. The failed sample was thoroughly investigated and its characteristics were compared with those of other liners at different stages of production of a Type IV cylinder (blow molding, curing of the composite material). An examination of the liner showed that no significant chemical and morphological changes occurred during the production cycle of a Type IV cylinder that could justify the liner rupture, and that the most likely cause of failure was a design-related fatigue phenomenon.
Mechanical and Fire Properties of Flame-Retardant Laminated Bamboo Lumber Glued with Phenol Formaldehyde and Melamine Urea Formaldehyde Adhesives
Authors: He Ying , Jin Xiaobei , Li Jingpeng , Qin Daochun
Published: March 2024

This study investigated the effects of different adhesives, phenol formaldehyde (PF) and melamine urea formaldehyde (MUF), on the mechanical and fire properties of flame-retardant laminated bamboo lumber (LBL). The results demonstrated that the flame-retardant treatment using phosphorus–nitrogen–boron compounds endowed the LBL with excellent flame retardancy and smoke suppression properties, even though the bending strength and bond shear strength were slightly reduced. The PF-glued LBL exhibited superior mechanical and shear properties to the MUF-glued ones, primarily due to its higher processing temperature and deeper adhesive penetration. In addition, the MUF-glued flame-retardant LBL displayed better heat release reduction and smoke suppression properties than the PF-glued LBL, which resulted from the synergistic flame retardancy between the melamine element in MUF and the applied flame retardant. The analysis of the influence of adhesive type on the mechanical and fire properties of flame-retardant LBL holds significant importance for the future design and production of high-performance LBL material.
Fusedly Deposited Frequency-Selective Composites Fabricated by a Dual-Nozzle 3D Printing as Microwave Filter
Authors: Cho Jae-Yeon , Oh Young-Chan , Shin Seung-Cheol , Lee Sun-Kon , Seo Hyoung-Seock , Lee Sang-Eui
Published: March 2024

We report a fusedly deposited frequency-selective composite (FD-FSCs), fabricated with a dual-nozzle 3D printer using a conductive carbon black (CB) polylactic acid (PLA) composite filament and a pure PLA polymer filament. The square frequency-selective pattern was constructed by the conductive CB/PLA nanocomposite, and the apertures of the pattern were filled with the pure dielectric PLA material, which allows the FD-FSC to maintain one single plane, even under bending, and also affects the resonating frequency due to the characteristic impedance of PLA (εr′ ≈ 2.0). The number of the deposition layer and the printing direction were observed to affect electrical conductivity, complex permittivity, and the frequency selectivity of the FD-FSCs. In addition, the FD-FSCs designed for an X-band showed partial transmission around the resonant frequency and was observed to, quite uniformly, transmit microwaves in the decibel level of −2.17~−2.83 dB in the whole X-band, unlike a metallic frequency selective surface with full transmission at the resonance frequency. FD-FSCs embedded radar absorbing structure (RAS) demonstrates an excellent microwave absorption and a wide effective bandwidth. At a thickness of 4.3 mm, the 10 dB bandwidth covered the entire X-band (8.2~12.4 GHz) range of 4.2 GHz. Therefore, the proposed FD-FSCs fabricated by dual-nozzle 3D printing can be an impedance modifier to expand the design space and the application of radar absorbing materials and structures.
A Review of the Strategic Use of Sodium Alginate Polymer in the Immobilization of Microorganisms for Water Recycling
Authors: Bustos-Terrones Yaneth A.
Published: March 2024

In the quest for advanced and environmentally friendly solutions to address challenges in the field of wastewater treatment, the use of polymers such as sodium alginate (Na-Alg) in combination with immobilized microorganisms (IMs) stands out as a promising strategy. This study assesses the potential of Na-Alg in immobilizing microorganisms for wastewater treatment, emphasizing its effectiveness and relevance in environmental preservation through the use of IMs. Advances in IMs are examined, and the interactions between these microorganisms and Na-Alg as the immobilization support are highlighted. Additionally, models for studying the kinetic degradation of contaminants and the importance of oxygen supply to IMs are detailed. The combination of Na-Alg with IMs shows promise in the context of improving water quality, preserving ecological balance, and addressing climate change, but further research is required to overcome the identified challenges. Additional areas to explore are discussed, which are expected to contribute to the innovation of relevant systems.
Using Co-Ordinate Systems in Hedonic Housing Regressions
Authors: Caudill Steven B. , Manage Neela , Mixon Franklin G.
Published: March 2024

Hedonic house price studies typically incorporate information about location by including either a set of dummy variables to represent individual locations called “neighborhoods” or by using a set of distance (or travel time) variables to characterize locations in terms of proximity to amenities and dis-amenities. As an alternative to these, relatively recent research advocates a latitude–longitude co-ordinate system for incorporating distance information into hedonic house price regressions. This study shows that many of the claims made in this research, particularly those referencing the elimination or diminution of “biases of coefficients of non-distance variables”, are given the particulars of the Monte Carlo experiments, not possible to investigate. We further show, both analytically and with our simulations, that there is no omitted variable bias present in their simulations because their randomly generated non-distance variable is uncorrelated with any of the other variables used in their regression models.
Queering John of the Cross: Sanjuanist Contributions to the Fight against Phobias towards Queer People
Authors: Santos Meza Anderson Fabian
Published: March 2024

This article aims to approach Sanjuanist mysticism from a queer perspective. It is not a monolithic apology to queer people, nor a treatise on mystical interpretation, but an effort to recognize and validate the spiritual experience of LGBTIQ+ people. It takes some mystical passages from St. John of the Cross that help to read the experience of queer life in a mystical key. With this, the potential of mysticism to combat those phobic, segregating, and unjust ideologies that mistreat so many people because of their sexual orientation and gender identity dissidence is manifested. Although it is problematic, talking about this is an act of epistemic, sociocultural, and religious justice.
Religion Matters: Religion and the Sustainable Development Goals (SDGs)
Authors: Schliesser Christine
Published: March 2024

With 85% of this planet’s population adhering to a religion, faith communities are the largest transnational civil society actors in the world. This accords them a major role in societal processes, aincluding current global challenges as spelled out in the 17 SDGs, the core of the Agenda 2030. After decades of neglect, recent years have seen a rise in interest in the role of religion in the public agenda. Academics, policymakers and practitioners alike increasingly acknowledge the significance of faith actors for the SDGs. Key terms such as “Common Home”, shared by faith and secular actors, already indicate their mutual relevance. At the same time, there is a lack of religious literacy in recognizing and interpreting religious dimensions in a given development context. This paper therefore seeks to shed light on the often nebulous “religious factor” in the SDGs in two consecutive steps. At first, the historical part traces the rise of religion in development. In the second step, an analytical part then provides a seven-dimensional model to enhance religious literacy and to provide a better understanding of both the potential and the problems of religion in the global quest for implementing the SDGs.
Correlates of Spirituality among African American and Black Caribbean Emerging Adults
Authors: Hope Meredith , Nguyen Ann , Taylor Robert , Chatters Linda
Published: March 2024

Spirituality is a significant cultural strength and resource for Black emerging adults. Numerous studies show that increasing numbers of emerging adults tend to identify themselves as being spiritual but not religious. However, no studies to date have identified the demographic correlates of spirituality for Black emerging adults from different ethnic groups (i.e., African American and Black Caribbean). Data from the National Survey of American Life were used to identify the demographic correlates of two indicators of spirituality (e.g., self-rated spirituality and subjective spirituality) among African American and Black Caribbean emerging adults using linear regression. For African Americans, being a woman predicted both greater self-rated spirituality and subjective spirituality. However, among Black Caribbeans, men rated spirituality higher in importance than women. African Americans who reported higher educational attainment tended to report higher levels of self-rated spirituality and subjective spirituality. Romantic status for Black Caribbeans, whether they had no romantic involvement or a current romantic partner, was associated with lower self-ratings of spirituality. Unmarried cohabitating individuals in both ethnic groups tended to report lower levels of self-related spirituality. Unemployment for Black Caribbeans was associated with lower subjective spirituality. Findings are of interest to those who serve and work with Black emerging adults.
Aboveground Biomass and Carbon Storage in Mangrove Forests in Southeastern Mexico
Authors: Ávila-Acosta Carlos Roberto , Domínguez-Domínguez Marivel , Vázquez-Navarrete César Jesús , Acosta-Pech Rocío Guadalupe , Martínez-Zurimendi Pablo
Published: March 2024

The aboveground contributions of mangroves to global carbon sequestration reinforce the need to estimate biomass in these systems. The objective was to determine the aboveground biomass storage and quantify the carbon and CO2e content in Rhizophora mangle, Avicennia germinans, and Laguncularia racemosa present in southeastern Mexico. Based on the Forest Protocol for Mexico Version 2.0 methodology, published by Climate Action Reserve, 130 circular plots were randomly selected and established in an area of 930 ha of mangrove vegetation, and the aboveground biomass and stored carbon were determined. The mangrove had a density of 3515 ± 428.5 individuals per hectare. The aboveground biomass of the three species was 120.5 Mg ha−1. The biomass of L. racemosa was 99.5 Mg ha−1, which represents 82.6% of the total biomass. The biomass of R. mangle was 20.33 Mg ha−1, and that of A. germinans was 0.32 Mg ha−1. The total carbon retained in the trees was 60.25 Mg C ha−1 and 221.1 Mg CO2e ha−1. Laguncularia racemosa generated the highest contributions of CO2e. The area of mangroves accumulated 112,065 Mg of aboveground biomass. The carbon contained in this biomass corresponds to 205,623 Mg CO2e. This mangrove contributes to mitigating the effects of climate change globally through the reduction in greenhouse gases.
Accuracy Evaluation of Ocean Wave Spectra from Sentinel-1 SAR Based on Buoy Observations and ERA5 Data
Authors: Sun Fengjia , Yang Jungang , Cui Wei
Published: March 2024

Doppler mis-registrations in azimuth can lead to ocean waves shorter than a specific wavelength being undetectable by SAR. In order to evaluate the actual ocean wave observation ability, the accuracy of Sentinel-1 SAR ocean wave spectra from January 2016 to December 2021 is evaluated by comparisons to NDBC buoys, ERA5 wave height, and CMEMS buoys. The results compared with NDBC show that the spectral shape of Sentinel-1 SAR ocean wave spectra is accurate, while the spectral values need to be improved. The wave spectra of Sentinel-1 have the best observations in season autumn. The comparison results of total wave height show the RMSE and bias are 0.91 m and −0.52 m for the comparisons to NDBC buoy wave spectra data, 0.93 m and −0.68 m for the comparison to ERA5 wave height data, and 0.9 m and −0.35 m for the comparisons to CMEMS buoy data. The comparison results of wave height in different wind speeds and areas shows that the accuracy of Sentinel-1 wave mode data is relatively good in the open ocean located in middle and low latitude area under the medium wind speed, while those are relatively poor in high latitude areas or the areas with excessively high or low wind speed.
A Region-Adaptive Local Perturbation-Based Method for Generating Adversarial Examples in Synthetic Aperture Radar Object Detection
Authors: Duan Jiale , Qiu Linyao , He Guangjun , Zhao Ling , Zhang Zhenshi , Li Haifeng
Published: March 2024

In synthetic aperture radar (SAR) imaging, intelligent object detection methods are facing significant challenges in terms of model robustness and application security, which are posed by adversarial examples. The existing adversarial example generation methods for SAR object detection can be divided into two main types: global perturbation attacks and local perturbation attacks. Due to the dynamic changes and irregular spatial distribution of SAR coherent speckle backgrounds, the attack effectiveness of global perturbation attacks is significantly reduced by coherent speckle. In contrast, by focusing on the image objects, local perturbation attacks achieve targeted and effective advantages over global perturbations by minimizing interference from the SAR coherent speckle background. However, the adaptability of conventional local perturbations is limited because they employ a fixed size without considering the diverse sizes and shapes of SAR objects under various conditions. This paper presents a framework for region-adaptive local perturbations (RaLP) specifically designed for SAR object detection tasks. The framework consists of two modules. To address the issue of coherent speckle noise interference in SAR imagery, we develop a local perturbation generator (LPG) module. By filtering the original image, this module reduces the speckle features introduced during perturbation generation. It then superimposes adversarial perturbations in the form of local perturbations on areas of the object with weaker speckles, thereby reducing the mutual interference between coherent speckles and adversarial perturbation. To address the issue of insufficient adaptability in terms of the size variation in local adversarial perturbations, we propose an adaptive perturbation optimizer (APO) module. This optimizer adapts the size of the adversarial perturbations based on the size and shape of the object, effectively solving the problem of adaptive perturbation size and enhancing the universality of the attack. The experimental results show that RaLP reduces the detection accuracy of the YOLOv3 detector by 29.0%, 29.9%, and 32.3% on the SSDD, SAR-Ship, and AIR-SARShip datasets, respectively, and the model-to-model and dataset-to-dataset transferability of RaLP attacks are verified.
Application of Polynomial Interpolation for Iterative Complementation of the Missing Nodes in a Regular Network of Squares Used for the Construction of a Digital Terrain Model
Authors: Gościewski Dariusz , Gerus-Gościewska Małgorzata , Szczepańska Agnieszka
Published: March 2024

Due to the continuous increase in the volume of spatially located information, the current requirements imposed on the Spatial Information System (SIS) concern increasing data mining capabilities. Modern measurement systems, based on devices which enable the automatic recording of observation results on a mass scale (LiDAR—Light Detection and Ranging, MBES—Multi Beam Echo Sounder, etc.), allow for a very large volume of information on the surface to be measured and acquired in a relatively short time. One of the methods to reduce the volume of data enabling the generation of a model surface is to convert unevenly distributed measurement points into a regular network of squares (GRID). However, the generation of a complete grid is not always possible. In the measurement spectrum, there may be areas where measurement points have not been recorded. Measurement points can also be eliminated by either filtering the erroneously recorded data or eliminating the measured vegetation or the utilities in the area. To address these problems, the current article proposes a method for complementing the missing internal nodes in a regular network of squares using polynomial interpolation algorithms. Moreover, the paper demonstrates the possibilities of using the presented method for adding additional points between the already existing nodes of the network of squares. The application of the methodology presented in this article enables the effective elimination of (or a reduction in) the gaps in the GRID structure, which, in turn, allows such a network of squares to be used to generate a more accurate Digital Terrain Model.
Interpretation of Geological Features and Volcanic Activity in the Tsiolkovsky Region of the Moon
Authors: Wang Ying , Ding Xiaozhong , Chen Jian , Han Kunying , Shi Chenglong , Jin Ming , Liu Liwei , Liu Xinbao , Deng Jiayin
Published: March 2024

The Tsiolkovsky crater is located on the farside of the Moon. It formed in the late Imbrian epoch and was filled with a large area of mare basalts. Multisource remote sensing data are used to interpret the geological features of the Tsiolkovsky area. Compared with previous studies, new remote sensing data and a chronological model based on crater size–frequency distribution are used to further refine the stratigraphic units and determine the absolute ages of the mare basalt units. The evolution of volcanic activity in this crater is discussed. The results are as follows: Abundances of major elements, Th, and silicate minerals suggest that the mare basalt in the crater floor is not a uniform unit but rather nine units with different compositions. The nine basalt units are divided into two episodes of volcanic activity: The first occurred at 3.5–3.7 Ga, when highly evolved lava erupted at the crater floor at a large scale; the second occurred at ~3.4 Ga, when a small area of more primitive lava extended to the northern portion of the crater floor.