bluuebunny/crossref_metadata_2025 huggingface dataset:
Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence
Authors: Sultan Maria , Arya Rekha , Kim Kyeong Kyu
Published: November 2021

Pseudomonas aeruginosa is an opportunistic pathogen that synthesizes and secretes a wide range of virulence factors. P. aeruginosa poses a potential threat to human health worldwide due to its omnipresent nature, robust host accumulation, high virulence, and significant resistance to multiple antibiotics. The pathogenicity of P. aeruginosa, which is associated with acute and chronic infections, is linked with multiple virulence factors and associated secretion systems, such as the ability to form and utilize a biofilm, pili, flagella, alginate, pyocyanin, proteases, and toxins. Two-component systems (TCSs) of P. aeruginosa perform an essential role in controlling virulence factors in response to internal and external stimuli. Therefore, understanding the mechanism of TCSs to perceive and respond to signals from the environment and control the production of virulence factors during infection is essential to understanding the diseases caused by P. aeruginosa infection and further develop new antibiotics to treat this pathogen. This review discusses the important virulence factors of P. aeruginosa and the understanding of their regulation through TCSs by focusing on biofilm, motility, pyocyanin, and cytotoxins.
Expression of Specific Alleles of Zinc-Finger Transcription Factors, HvSAP8 and HvSAP16, and Corresponding SNP Markers, Are Associated with Drought Tolerance in Barley Populations
Authors: Baidyussen Akmaral , Jatayev Satyvaldy , Khassanova Gulmira , Amantayev Bekzak , Sereda Grigory , Sereda Sergey , Gupta Narendra K. , Gupta Sunita , Schramm Carly , Anderson Peter , Jenkins Colin L. D. , Soole Kathleen L. , Langridge Peter , Shavrukov Yuri
Published: November 2021

Two genes, HvSAP8 and HvSAP16, encoding Zinc-finger proteins, were identified earlier as active in barley plants. Based on bioinformatics and sequencing analysis, six SNPs were found in the promoter regions of HvSAP8 and one in HvSAP16, among parents of two barley segregating populations, Granal × Baisheshek and Natali × Auksiniai-2. ASQ and Amplifluor markers were developed for HvSAP8 and HvSAP16, one SNP in each gene, and in each of two populations, showing simple Mendelian segregation. Plants of F6 selected breeding lines and parents were evaluated in a soil-based drought screen, revealing differential expression of HvSAP8 and HvSAP16 corresponding with the stress. After almost doubling expression during the early stages of stress, HvSAP8 returned to pre-stress level or was strongly down-regulated in plants with Granal or Baisheshek genotypes, respectively. For HvSAP16 under drought conditions, a high expression level was followed by either a return to original levels or strong down-regulation in plants with Natali or Auksiniai-2 genotypes, respectively. Grain yield in the same breeding lines and parents grown under moderate drought was strongly associated with their HvSAP8 and HvSAP16 genotypes. Additionally, Granal and Natali genotypes with specific alleles at HvSAP8 and HvSAP16 were associated with improved performance under drought via higher 1000 grain weight and more shoots per plant, respectively.
Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review
Authors: Payet Melissa , Dargai Farouk , Gasque Philippe , Guillot Xavier
Published: November 2021

The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on miR expression, DNA methylation and histone modifications in RA. We demonstrated that, in human samples, the expressions of miR-155, miR-146a and miR-150 were significantly decreased while the expression of miR-410-3p was significantly increased in the RA group. Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA. In a murine model, miR-34a inhibition can ameliorate the arthritis score. However, this evidence remain critically insufficient to support current therapeutic applications in RA patients.
Insertion of Calcium-Permeable AMPA Receptors during Epileptiform Activity In Vitro Modulates Excitability of Principal Neurons in the Rat Entorhinal Cortex
Authors: Amakhin Dmitry V. , Soboleva Elena B. , Chizhov Anton V. , Zaitsev Aleksey V.
Published: November 2021

Epileptic activity leads to rapid insertion of calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (CP-AMPARs) into the synapses of cortical and hippocampal glutamatergic neurons, which generally do not express them. The physiological significance of this process is not yet fully understood; however, it is usually assumed to be a pathological process that augments epileptic activity. Using whole-cell patch-clamp recordings in rat entorhinal cortex slices, we demonstrate that the timing of epileptiform discharges, induced by 4-aminopyridine and gabazine, is determined by the shunting effect of Ca2+-dependent slow conductance, mediated predominantly by K+-channels. The blockade of CP-AMPARs by IEM-1460 eliminates this extra conductance and consequently increases the rate of discharge generation. The blockade of NMDARs reduced the additional conductance to a lesser extent than the blockade of CP-AMPARs, indicating that CP-AMPARs are a more significant source of intracellular Ca2+. The study’s main findings were implemented in a mathematical model, which reproduces the shunting effect of activity-dependent conductance on the generation of discharges. The obtained results suggest that the expression of CP-AMPARs in principal neurons reduces the discharge generation rate and may be considered as a protective mechanism.
Impact of Air Transport on SpO2/FiO2 among Critical COVID-19 Patients during the First Pandemic Wave in France
Authors: Bouillon-Minois Jean-Baptiste , Roux Vincent , Jabaudon Matthieu , Flannery Mara , Duchenne Jonathan , Dumesnil Maxime , Paillard-Turenne Morgane , Gendre Paul-Henri , Grapin Kévin , Rieu Benjamin , Dutheil Frédéric , Croizier Carolyne , Schmidt Jeannot , Pereira Bruno
Published: November 2021

During the first wave of the COVID-19 pandemic, some French regions were more affected than others. To relieve those areas most affected, the French government organized transfers of critical patients, notably by plane or helicopter. Our objective was to investigate the impact of such transfers on the pulse oximetric saturation (SpO2)-to-inspired fraction of oxygen (FiO2) ratio among transferred critical patients with COVID-19. We conducted a retrospective study on medical and paramedical records. The primary endpoint was the change in SpO2/FiO2 during transfers. Thirty-eight patients were transferred between 28 March and 5 April 2020, with a mean age of 62.4 years and a mean body mass index of 29.8 kg/m2. The population was 69.7% male, and the leading medical history was hypertension (42.1%), diabetes (34.2%), and dyslipidemia (18.4%). Of 28 patients with full data, we found a decrease of 28.9 points in SpO2/FiO2 (95% confidence interval, 5.8 to 52.1, p = 0.01) between the starting and the arrival intensive care units (SpO2/FiO2, 187.3 ± 61.3 and 158.4 ± 62.8 mmHg, respectively). Air medical transfers organized to relieve intensive care unit teams under surging conditions during the first COVID wave were associated with significant decreases in arterial oxygenation.
Clinical Outcome and 8-Year Follow-Up of Alveolar Bone Tissue Engineering for Severely Atrophic Alveolar Bone Using Autologous Bone Marrow Stromal Cells with Platelet-Rich Plasma and β-Tricalcium Phosphate Granules
Authors: Asahina Izumi , Kagami Hideaki , Agata Hideki , Honda Masaki J. , Sumita Yoshinori , Inoue Minoru , Nagamura-Inoue Tokiko , Tojo Arinobu
Published: November 2021

Background: Although bone tissue engineering for dentistry has been studied for many years, the clinical outcome for severe cases has not been established. Furthermore, there are limited numbers of studies that include long-term follow-up. In this study, the safety and efficacy of bone tissue engineering for patients with a severely atrophic alveolar bone were examined using autogenous bone marrow stromal cells (BMSCs), and the long-term stability was also evaluated. Methods: BMSCs from iliac bone marrow aspirate were cultured and expanded. Then, induced osteogenic cells were transplanted with autogenous platelet-rich plasma (PRP) and β-tricalcium phosphate granules (β-TCP) for maxillary sinus floor and alveolar ridge augmentation. Eight patients (two males and six females) with an average age of 54.2 years underwent cell transplantation. Safety was assessed by monitoring adverse events. Radiographic evaluation and bone biopsies were performed to evaluate the regenerated bone. Results: The major population of transplanted BMSCs belonged to the fraction of CD34−, CD45dim, and CD73+ cells, which was only 0.065% of the total bone marrow cells. Significant deviations were observed in cell growth and alkaline phosphatase activities among individuals. However, bone regeneration was observed in all patients and the average bone area in the biopsy samples was 41.9% 6 months following transplantation, although there were also significant deviations among each case. No adverse events related to the transplants were observed. In the regenerated bone, 27 out of 29 dental implants were integrated. Dental implants and regenerated bone were stable for an average follow-up period of 7 years and 10 months. Conclusions: Although individual variations were observed, the results showed that bone tissue engineering using BMSCs with PRP and β-TCP was feasible for patients with severe atrophic maxilla throughout a long-term follow-up period and was considered safe. However, further studies with a larger number of cases and controls to confirm the efficacy of BMSCs and the development of a protocol to establish a reproducible quality of stem cell-based graft material will be required.
An Experimental Study of the Cyclic Compression after Impact Behavior of CFRP Composites
Authors: Bogenfeld Raffael , Gorsky Christopher
Published: November 2021

The behavior of impact damaged composite laminates under cyclic load is crucial to achieve a damage tolerant design of composite structures. A sufficient residual strength has to be ensured throughout the entire structural service life. In this study, a set of 27 impacted coupon specimens is subjected to quasi-static and cyclic compression load. After long intervals without detectable damage growth, the specimens fail through the sudden lateral propagation of delamination and fiber kink bands within few load cycles. Ultrasonic inspections were used to reveal the damage size after certain cycle intervals. Through continuous dent depth measurements during the cyclic tests, the evolution of the dent visibility was monitored. These measurements revealed a relaxation of the indentation of up to 90% before ultimate failure occurs. Due to the distinct relaxation and the short growth interval before ultimate failure, this study confirms the no-growth design approach as the preferred method to account for the damage tolerance of stiffened, compression-loaded composite laminates.
Depth-Related Curing Potential of Ormocer- and Dimethacrylate-Based Bulk-Fill Composites
Authors: Oltramare Ramona S. , Odermatt Reto , Burrer Phoebe , Attin Thomas , Tauböck Tobias T.
Published: November 2021

The aim of this in vitro study was to investigate the degree of C=C double bond conversion of high-viscosity dimethacrylate- or ormocer-based bulk-fill composites as a function of measurement depth. Four bulk-fill composites (Tetric EvoCeram Bulk Fill, x-tra fil, SonicFill, and Bulk Ormocer) and the conventional nanohybrid composite Tetric EvoCeram were applied in standardized Class II cavities (n = 6 per group) and photoactivated for 20 s at 1350 mW/cm2. The degree of conversion of the composites was assessed using Fourier-transform infrared spectroscopy at seven measurement depths (0.15, 1, 2, 3, 4, 5, 6 mm). Data were analyzed using repeated measures ANOVA and one-way ANOVA with Bonferroni post-hoc tests (α = 0.05). The investigated bulk-fill composites showed at least 80% of their maximum degree of conversion (80% DCmax) up to a measuring depth of at least 4 mm. Tetric EvoCeram Bulk Fill and Bulk Ormocer achieved more than 80% DCmax up to a measuring depth of 5 mm, x-tra fil up to 6 mm. The conventional nanohybrid composite Tetric EvoCeram achieved more than 80% DCmax up to 3 mm. In contrast to the conventional composite, the investigated ormocer- and dimethacrylate-based bulk-fill composites can be photo-polymerized in thick layers of up to at least 4 mm with regard to their degree of C=C double bond conversion.
Investigation of Er3+ Ions Reinforced Zinc-Phosphate Glasses for Ionizing Radiation Shielding Applications
Authors: Zakaly Hesham M. H. , Ene Antoaneta , Olarinoye Oyeleke I. , Marzouk Samir Y. , Abdel-Hafez Shams H. , Shams Mohamed S. , Rammah Yasser S.
Published: November 2021

Melt quenching technique is used for preparing glasses with chemical formula (70P2O5)–(16 − x)CdO–(14ZnO)–(xEr2O3), (x = 1–6 mol%). These glasses were named Er1, Er2, Er3, Er4, Er5, and Er6, respectively. Photon buildup factors, fast neutron absorption, and electron stopping of the prepared glasses were examined. Glasses’ density was varied from 3.390 ± 0.003 for the Er1 glass sample to 3.412 ± 0.003 for the Er6 glass sample. The Buildup factor (BUF) spectra have relatively higher values in the Compton Scattering (CS) dominated areas compared to both Photoelectric effect (PE), and Pair Production (PP) dominated energy regions. The highest BUF appeared at the Er atom K-absorption edge, whose intensity increases as the molar concentration of Er2O3 in the glasses increases. The photon absorption efficiency (PAE) of the glasses increases according to the trend (PAE)Er1 < (PAE)Er2 < (PAE)Er3 < (PAE)Er4 < (PAE)Er5 < (PAE)Er6. Fast neutron removal cross-section, FNRC (ΣR) values of the glasses obtained via calculation varied from 0.1045–0.1039 cm−1 for Er1–Er6. Furthermore, the continuous slowing down approximation mode (CSDA) range enhances the kinetic energy of electrons for all glasses. Generally, results revealed that the investigated glasses could be applied for radiation shielding and dosimetric media.
Effects of Non-Stoichiometry on the Ground State of the Frustrated System Li0.8Ni0.6Sb0.4O2
Authors: Vavilova Evgeniya , Salikhov Timur , Iakovleva Margarita , Vasilchikova Tatyana , Zvereva Elena , Shukaev Igor , Nalbandyan Vladimir , Vasiliev Alexander
Published: November 2021

The non-stoichiometric system Li0.8Ni0.6Sb0.4O2 is a Li-deficient derivative of the zigzag honeycomb antiferromagnet Li3Ni2SbO6. Structural and magnetic properties of Li0.8Ni0.6Sb0.4O2 were studied by means of X-ray diffraction, magnetic susceptibility, specific heat, and nuclear magnetic resonance measurements. Powder X-ray diffraction data shows the formation of a new phase, which is Sb-enriched and Li-deficient with respect to the structurally honeycomb-ordered Li3Ni2SbO6. This structural modification manifests in a drastic change of the magnetic properties in comparison to the stoichiometric partner. Bulk static (dc) magnetic susceptibility measurements show an overall antiferromagnetic interaction (Θ = −4 K) between Ni2+ spins (S = 1), while dynamic (ac) susceptibility reveals a transition into a spin glass state at a freezing temperature TSG ~ 8 K. These results were supported by the absence of the λ-anomaly in the specific heat Cp(T) down to 2 K. Moreover, combination of the bulk static susceptibility, heat capacity and 7Li NMR studies indicates a complicated temperature transformation of the magnetic system. We observe a development of a cluster spin glass, where the Ising-like Ni2+ magnetic moments demonstrate a 2D correlated slow short-range dynamics already at 12 K, whereas the formation of 3D short range static ordered clusters occurs far below the spin-glass freezing temperature at T ~ 4 K as it can be seen from the 7Li NMR spectrum.
A Mating Selection Based on Modified Strengthened Dominance Relation for NSGA-III
Authors: Dutta Saykat , M Sri Srinivasa Raju , Mallipeddi Rammohan , Das Kedar Nath , Lee Dong-Gyu
Published: November 2021

In multi/many-objective evolutionary algorithms (MOEAs), to alleviate the degraded convergence pressure of Pareto dominance with the increase in the number of objectives, numerous modified dominance relationships were proposed. Recently, the strengthened dominance relation (SDR) has been proposed, where the dominance area of a solution is determined by convergence degree and niche size (θ¯). Later, in controlled SDR (CSDR), θ¯ and an additional parameter (k) associated with the convergence degree are dynamically adjusted depending on the iteration count. Depending on the problem characteristics and the distribution of the current population, different situations require different values of k, rendering the linear reduction of k based on the generation count ineffective. This is because a particular value of k is expected to bias the dominance relationship towards a particular region on the Pareto front (PF). In addition, due to the same reason, using SDR or CSDR in the environmental selection cannot preserve the diversity of solutions required to cover the entire PF. Therefore, we propose an MOEA, referred to as NSGA-III*, where (1) a modified SDR (MSDR)-based mating selection with an adaptive ensemble of parameter k would prioritize parents from specific sections of the PF depending on k, and (2) the traditional weight vector and non-dominated sorting-based environmental selection of NSGA-III would protect the solutions corresponding to the entire PF. The performance of NSGA-III* is favourably compared with state-of-the-art MOEAs on DTLZ and WFG test suites with up to 10 objectives.
A Novel Approach Combining Particle Swarm Optimization and Deep Learning for Flash Flood Detection from Satellite Images
Authors: Tuyen Do Ngoc , Tuan Tran Manh , Son Le Hoang , Ngan Tran Thi , Giang Nguyen Long , Thong Pham Huy , Hieu Vu Van , Gerogiannis Vassilis C. , Tzimos Dimitrios , Kanavos Andreas
Published: November 2021

Flood is one of the deadliest natural hazards worldwide, with the population affected being more than 2 billion between 1998–2017 with a lack of warning systems according to WHO. Especially, flash floods have the potential to generate fatal damages due to their rapid evolution and the limited warning and response time. An effective Early Warning Systems (EWS) could support detection and recognition of flash floods. Information about a flash flood can be mainly provided from observations of hydrology and from satellite images taken before the flash flood happens. Then, predictions from satellite images can be integrated with predictions based on sensors’ information to improve the accuracy of a forecasting system and subsequently trigger warning systems. The existing Deep Learning models such as UNET has been effectively used to segment the flash flood with high performance, but there are no ways to determine the most suitable model architecture with the proper number of layers showing the best performance in the task. In this paper, we propose a novel Deep Learning architecture, namely PSO-UNET, which combines Particle Swarm Optimization (PSO) with UNET to seek the best number of layers and the parameters of layers in the UNET based architecture; thereby improving the performance of flash flood segmentation from satellite images. Since the original UNET has a symmetrical architecture, the evolutionary computation is performed by paying attention to the contracting path and the expanding path is synchronized with the following layers in the contracting path. The UNET convolutional process is performed four times. Indeed, we consider each process as a block of the convolution having two convolutional layers in the original architecture. Training of inputs and hyper-parameters is performed by executing the PSO algorithm. In practice, the value of Dice Coefficient of our proposed model exceeds 79.75% (8.59% higher than that of the original UNET model). Experimental results on various satellite images prove the advantages and superiority of the PSO-UNET approach.
Numerical Modeling on Crack Propagation Based on a Multi-Grid Bond-Based Dual-Horizon Peridynamics
Authors: Dai Zili , Xie Jinwei , Lu Zhitang , Qin Shiwei , Wang Lin
Published: November 2021

Peridynamics (PD) is a novel nonlocal theory of continuum mechanics capable of describing crack formation and propagation without defining any fracture rules in advance. In this study, a multi-grid bond-based dual-horizon peridynamics (DH-PD) model is presented, which includes varying horizon sizes and can avoid spurious wave reflections. This model incorporates the volume correction, surface correction, and a technique of nonuniformity discretization to improve calculation accuracy and efficiency. Two benchmark problems are simulated to verify the reliability of the proposed model with the effect of the volume correction and surface correction on the computational accuracy confirmed. Two numerical examples, the fracture of an L-shaped concrete specimen and the mixed damage of a double-edged notched specimen, are simulated and analyzed. The simulation results are compared against experimental data, the numerical solution of a traditional PD model, and the output from a finite element model. The comparisons verify the calculation accuracy of the corrected DH-PD model and its advantages over some other models like the traditional PD model.
Natural Products from Actinomycetes Associated with Marine Organisms
Authors: Chen Jianing , Xu Lin , Zhou Yanrong , Han Bingnan
Published: November 2021

The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.
Effect of Leg Extension Angle on Knee Flexion Angle during Swing Phase in Post-Stroke Gait
Authors: Matsuzawa Yuta , Miyazaki Takasuke , Takeshita Yasufumi , Higashi Naoto , Hayashi Hiroyuki , Araki Sota , Nakatsuji Shintaro , Fukunaga Seiji , Kawada Masayuki , Kiyama Ryoji
Published: November 2021

Background and Objectives: Leg extension angle is important for increasing the propulsion force during gait and is a meaningful indicator for evaluating gait quality in stroke patients. Although leg extension angle during late stance might potentially also affect lower limb kinematics during the swing phase, the relationship between these two remains unclear. This study aimed to investigate the relationship between leg extension angle and knee flexion angle during pre-swing and swing phase in post-stroke gait. Materials and Methods: Twenty-nine stroke patients walked along a 16 m walkway at a self-selected speed. Tilt angles and acceleration of pelvis and paretic lower limb segments were measured using inertial measurement units. Leg extension angle, consisting of a line connecting the hip joint with the ankle joint, hip and knee angles, and increments of velocity during pre-swing and swing phase were calculated. Correlation analysis was conducted to examine the relationships between these parameters. Partial correlation analysis adjusted by the Fugl-Meyer assessment-lower limb (FMA-LL) was also performed. Results: On the paretic side, leg extension angle was positively correlated with knee flexion angle during the swing phase (r = 0.721, p < 0.001) and knee flexion angle and increments of velocity during the pre-swing phase (r = 0.740–0.846, p < 0.001). Partial correlation analysis adjusted by the FMA-LL showed significant correlation between leg extension angle and knee flexion angle during the swing phase (r = 0.602, p = 0.001) and knee flexion angle and increments of velocity during the pre-swing phase (r = 0.655–0.886, p < 0.001). Conclusions: Leg extension angle affected kinematics during the swing phase in post-stroke gait regardless of the severity of paralysis, and was similar during the pre-swing phase. These results would guide the development of effective gait training programs that enable a safe and efficient gait for stroke patients.
L3 Skeletal Muscle Index Dynamics in Patients with HCV-Related Compensated Cirrhosis Following Sustained Virological Response after Direct Acting Antiviral Treatment
Authors: Mihai Florin , Trifan Anca , Stanciu Carol , Huiban Laura , Muzîca Cristina , Lupașcu-Ursulescu Corina , Negru Dragoș , Savin Marius Lucian , Gîrleanu Irina , Cuciureanu Tudor , Sîngeap Ana Maria
Published: November 2021

Background and Objectives: Sarcopenia is commonly associated with liver cirrhosis and predicts clinical outcome. Our aim was to identify the changes in skeletal muscle index (SMI) on computed tomography (CT) examination, as a quantitative marker of sarcopenia, in patients with HCV-related cirrhosis after direct acting antivirals (DAAs) treatment and to assess predictive factors for the evolution of SMI. Materials and Methods: This is a single center retrospective study in patients with HCV-related compensated cirrhosis who obtained sustained virological response (SVR) after DAAs. CT examinations were performed in 52 patients before and within 5–24 months after treatment. The total muscle area (TMA) of abdominal muscle at the level of third lumbar vertebra (L3) was measured at baseline and after SVR. The L3-SMI was calculated from TMA divided by body height squared (cm2/m2). We assessed changes in L3-SMI after SVR according to baseline body mass index (BMI) and laboratory data. Predictive factors were assessed by linear regression model. Results: Patients with L3-SMI above the gender-specific cut-off value at baseline had higher values of serum creatinine (median 0.73) compared to patients with low L3-SMI (median 0.68, p = 0.031). After SVR, 14 patients showed increase of L3-SMI, and 38 patients had a decrease of L3-SMI. BMI in the decreased L3-SMI group was significantly lower (median 26.17) than those without decreased L3-SMI (median 28.84, p = 0.021). ALT values in the decreased L3-SMI group (median 66.5) were significantly lower than those without a decrease in L3-SMI (median 88, p = 0.045). Conclusions: Low creatinine serum level correlates with sarcopenia. SMI was partially influenced by the viral clearance. Lower BMI and ALT serum levels at baseline were predictive for no benefit in terms of muscle mass dynamics. Understanding all the mechanisms involved in sarcopenia and identifying the most vulnerable patients could ensure optimal adapted care strategies.
Effect of Injected Oxygen Amount on the Gas Porosity and Mechanical Properties of a Pore-Free Die-Cast Al–Si–Cu Alloy
Authors: Kang Ho-Jung , Jang Ho-Sung , Oh Seong-Hyo , Yoon Pil-Hwan , Lee Gyu-Heun , Park Jin-Young , Choi Yoon-Suk
Published: November 2021

With the rise in the demand for eco-friendly and electric vehicles, welding and heat treatment are becoming very important to meet the necessary weight reduction, complexity, and high functionality of die castings. Pore-free (PF) die casting is an effective process that enables heat treatment and welding due to low gas porosities. Indeed, this process affords castings of low gas porosity, similar to those attained by high-vacuum die casting. In this study, we compared the gas porosities of different castings fabricated by PF die casting using varied injected oxygen amounts. The castings were all subjected to T6 heat treatment and analyzed by computed tomography (CT) to compare their microstructure and mechanical properties before and after T6 heat treatment. The results revealed that with the increasing injected oxygen amount, the gas porosity of the specimens decreased while their mechanical properties increased. In particular, the gas porosity was the lowest at 1.26 L. Moreover, the 1.26 L specimen displayed the best tensile strength, yield strength, and elongation results. Finally, Weibull distribution analysis revealed that the tensile strength and elongation repeatability and reproducibility increased with increasing injected oxygen amount.
Carbon-Based Coatings in Medical Textiles Surface Functionalisation: An Overview
Authors: Antunes José , Matos Karim , Carvalho Sandra , Cavaleiro Albano , Cruz Sandra M. A. , Ferreira Fábio
Published: November 2021

The COVID-19 pandemic has further highlighted the need for antimicrobial surfaces, especially those used in a healthcare environment. Textiles are the most difficult surfaces to modify since their typical use is in direct human body contact and, consequently, some aspects need to be improved, such as wear time and filtration efficiency, antibacterial and anti-viral capacity, or hydrophobicity. To this end, several techniques can be used for the surface modification of tissues, being magnetron sputtering (MS) one of [hose that have been growing in the last years to meet the antimicrobial objective. The current state of the art available on textile functionalisation techniques, the improvements obtained by using MS, and the potential of diamond-like-carbon (DLC) coatings on fabrics for medical applications will be discussed in this review in order to contribute to a higher knowledge of functionalized textiles themes.
Supervisory Power Coordination Scheme to Mitigate Power Curtailment in the Application of a Microgrid
Authors: Ko Heesang , Kim Gihoon , Nam Yanghyun , Ryu Kyungsang
Published: November 2021

There are cases where the output of renewable eappennergy (RE) is curtailed due to an increase in the share of RE. Typically, wind power (WP) is curtailed due to oversupply and low loads at midnight. However, there are cases where the output of WP is limited during the daytime due to the increase in the share of photovoltaics (PV). In the current electricity market, as the share of PV is increased, the curtailments of WP will be increased further, which will add to the difficulties experienced by wind farm operators. This paper proposes a supervisory power coordination scheme. The main purposes are to prevent the penetration of extra power from REs into the grid; thus, the curtailments can be prevented. In order to make it feasible, the proposed scheme is to design a grid-connected microgrid system to be operated only in response to loads and virtual power plant (VPP) requests. The effectiveness of the proposed scheme was verified by simulation studies conducted in the MATLAB/Simulink environment. The verification was conducted based on the voltage criteria, such as the AC voltage regulation between ±6% of the rated AC voltage, the DC voltage regulation between ±10% of the rated DC voltage, the power balance according to variations in the loads, and VPP requests for power. The simulation showed that the proposed scheme is feasible and justifiable, not only to mitigate the power curtailment problem but also to apply different system configurations.
Textile Wastewater Treatment in a Spinning Disc Reactor: Improved Performances—Experimental, Modeling and SVM Optimization
Authors: Zaharia Carmen , Leon Florin , Curteanu Silvia , Iacob-Tudose Eugenia Teodora
Published: November 2021

The paper presents an experimental study regarding the treatment of a real textile wastewater using the spinning disc (SD) technology, either individually or associated with an advanced Fenton oxidation step. The SD efficiency was investigated by studying the color, suspended solids, or turbidity removals, at distinctive feeding flowrates (10–30 L/h) and disc rotating speeds (100–1500 rpm). The data revealed increasing removal trends and allowed to establish the highest removal values. Based on obtained experimental results, the wastewater treatment efficiency by SD technology was reasonably good and thus, the WW indicators can be improved within relatively short periods of time. Additionally, based on supervised learning algorithms, the study includes treatment modeling for turbidity and color removal, followed by turbidity removal optimization relying on the best learned models. Satisfactory results obtained with the modeling and optimization procedures provide useful predictions for the approached treatment processes. Furthermore, within this study, a Fenton oxidation process was applied to SD technology to minimize the color and solids content. The influence of pH, hydrogen peroxide and ferrous ions concentrations was also investigated in order to establish the highest removal efficiencies. Overall, the SD technology applied in textile effluents treatment proved to be an appropriate and efficient alternative to classical mechanical step applied within the primary treatment step and, when associated with an advanced oxidative process in the secondary step, rendered good improvement, namely of 62.84% and 69.46% for color and respectively, suspended solids removal.
Reflexive Behaviour: How Publication Pressure Affects Research Quality in Astronomy
Authors: Heuritsch Julia
Published: November 2021

Reflexive metrics is a branch of science studies that explores how the demand for accountability and performance measurement in science has shaped the research culture in recent decades. Hypercompetition and publication pressure are part of this neoliberal culture. How do scientists respond to these pressures? Studies on research integrity and organisational culture suggest that people who feel treated unfairly by their institution are more likely to engage in deviant behaviour, such as scientific misconduct. By building up on reflexive metrics, combined with studies on the influence of organisational culture on research integrity, this study reflects on the research behaviour of astronomers with the following questions: (1) To what extent is research (mis-)behaviour reflexive, i.e., dependent on perceptions of publication pressure and distributive and organisational justice? (2) What impact does scientific misconduct have on research quality? In order to perform this reflection, we conducted a comprehensive survey of academic and non-academic astronomers worldwide and received 3509 responses. We found that publication pressure explains 19% of the variance in occurrence of misconduct and between 7% and 13% of the variance of the perception of distributive and organisational justice as well as overcommitment to work. Our results on the perceived impact of scientific misconduct on research quality show that the epistemic harm of questionable research practices should not be underestimated. This suggests there is a need for a policy change. In particular, lesser attention to metrics (such as publication rate) in the allocation of grants, telescope time and institutional rewards would foster better scientific conduct and, hence, research quality.
Adaptive Fast Non-Singular Terminal Sliding Mode Path Following Control for an Underactuated Unmanned Surface Vehicle with Uncertainties and Unknown Disturbances
Authors: Fan Yunsheng , Liu Bowen , Wang Guofeng , Mu Dongdong
Published: November 2021

This paper focuses on an issue involving robust adaptive path following for the uncertain underactuated unmanned surface vehicle with time-varying large sideslips angle and actuator saturation. An improved line-of-sight guidance law based on a reduced-order extended state observer is proposed to address the large sideslip angle that occurs in practical navigation. Next, the finite-time disturbances observer is designed by considering the perturbations parameter of the model and the unknown disturbances of the external environment as the lumped disturbances. Then, an adaptive term is introduced into Fast Non-singular Terminal Sliding Mode Control to design the path following controllers. Finally, considering the saturation of actuator, an auxiliary dynamic system is introduced. By selecting the appropriate design parameters, all the signals of the whole path following a closed-loop system can be ultimately bounded. Real-time control of path following can be achieved by transferring data from shipborne sensors such as GPS, combined inertial guidance and anemoclinograph to the Fast Non-singular Terminal Sliding Mode controller. Two examples as comparisons were carried out to demonstrate the validity of the proposed control approach.
Drift Suppression of Solution-Gated Graphene Field-Effect Transistors by Cation Doping for Sensing Platforms
Authors: Miyakawa Naruto , Shinagawa Ayumi , Kajiwara Yasuko , Ushiba Shota , Ono Takao , Kanai Yasushi , Tani Shinsuke , Kimura Masahiko , Matsumoto Kazuhiko
Published: November 2021

Solution-gated graphene field-effect transistors (SG-GFETs) provide an ideal platform for sensing biomolecules owing to their high electron/hole mobilities and 2D nature. However, the transfer curve often drifts in an electrolyte solution during measurements, making it difficult to accurately estimate the analyte concentration. One possible reason for this drift is that p-doping of GFETs is gradually countered by cations in the solution, because the cations can permeate into the polymer residue and/or between graphene and SiO2 substrates. Therefore, we propose doping sufficient cations to counter p-doping of GFETs prior to the measurements. For the pre-treatment, GFETs were immersed in a 15 mM sodium chloride aqueous solution for 25 h. The pretreated GFETs showed that the charge neutrality point (CNP) drifted by less than 3 mV during 1 h of measurement in a phosphate buffer, while the non-treated GFETs showed that the CNP was severely drifted by approximately 50 mV, demonstrating a 96% reduction of the drift by the pre-treatment. X-ray photoelectron spectroscopy analysis revealed the accumulation of sodium ions in the GFETs through pre-treatment. Our method is useful for suppressing drift, thus allowing accurate estimation of the target analyte concentration.
Theoretical Investigation of Glycine Micro-Solvated. Energy and NMR Spin Spin Coupling Constants Calculations
Authors: Caputo Maria Cristina , Provasi Patricio Federico
Published: November 2021

Glycine in its neutral form can exist in the gas phase while its zwitterion form is more stable in water solution, but how many waters are actually necessary to stabilize the zwitterionic structure in the gas phase? Are the intramolecular isotropic spin spin coupling constants sensitive enough to accuse the change in the environment? or the conformer observed? These and related questions have been investigated by a computational study at the level of density functional theory employing the B3LYP functional and the 6-31++G**-J basis set. We found that at least two water molecules explicitly accounted for in the super-molecule structure are necessary to stabilize both conformers of glycine within a water polarizable continuum model. At least half of the SSCCs of both conformers are very stable to changes in the environment and at least four of them differ significantly between Neutral and Zwitterion conformation.
Developing a Stabilizing Formulation of a Live Chimeric Dengue Virus Vaccine Dry Coated on a High-Density Microarray Patch
Authors: Choo Jovin J. Y. , McMillan Christopher L. D. , Fernando Germain J. P. , Hall Roy A. , Young Paul R. , Hobson-Peters Jody , Muller David A.
Published: November 2021

Alternative delivery systems such as the high-density microarray patch (HD-MAP) are being widely explored due to the variety of benefits they offer over traditional vaccine delivery methods. As vaccines are dry coated onto the HD-MAP, there is a need to ensure the stability of the vaccine in a solid state upon dry down. Other challenges faced are the structural stability during storage as a dried vaccine and during reconstitution upon application into the skin. Using a novel live chimeric virus vaccine candidate, BinJ/DENV2-prME, we explored a panel of pharmaceutical excipients to mitigate vaccine loss during the drying and storage process. This screening identified human serum albumin (HSA) as the lead stabilizing excipient. When bDENV2-coated HD-MAPs were stored at 4 °C for a month, we found complete retention of vaccine potency as assessed by the generation of potent virus-neutralizing antibody responses in mice. We also demonstrated that HD-MAP wear time did not influence vaccine deposition into the skin or the corresponding immunological outcomes. The final candidate formulation with HSA maintained ~100% percentage recovery after 6 months of storage at 4 °C.
Safety Profile of Recommended Vaccinations in Adolescents: Data from Surveillance of Adverse Events Following Immunization in Puglia (Italy), 2016–2020
Authors: Di Lorenzo Antonio , Bianchi Francesco Paolo , Martinelli Andrea , Lattanzio Sabrina , Carbonara Antonella , Diella Giusy , Tafuri Silvio , Stefanizzi Pasquale
Published: November 2021

Adolescence is a critical period for immunization, in which the adhesion rate to recommended vaccinations is often lower than desired. Since the safety of new vaccines is one of the most important factors determining vaccination hesitancy, post-marketing surveillance of adverse events following immunization (AEFIs) is recommended by the World Health Organization (WHO) to better understand the safety of these drugs. This report describes AEFIs notified in Puglia (Italy) after recommended vaccinations in adolescents aged 12 to 18 years in 2016–2020 to determine the safety profile of these products in a real-life scenario. This is a retrospective observational study. Data were gathered from the list of AEFIs notified in subjects between 12 and 18 years of age following administration of recommended vaccines in Puglia in 2016–2020. AEFIs were classified according to the WHO’s decisional algorithm, and causality assessment was carried out for serious AEFIs. From 2016 to 2020, 323,627 doses of vaccine were administered to adolescents in Puglia and 50 AEFIs were reported (reporting rate: 15.4 × 100,000 doses). Of these, 17 (34.0%) were classified as serious, and causality assessment identified 13 of them (76.5%) as vaccine related. The most common symptoms were local reactions, fever and neurological symptoms. No deaths were notified. The benefits of immunization in adolescents appear to be greater than the risk of AEFIs for all studied vaccines; in fact, AEFIs occur in less than 0.1‰ of patients and are generally mild and self-limiting.
Explaining COVID-19 Vaccine Rejection Using Social Cognitive Theory in Qassim, Saudi Arabia
Authors: AlSaeed Aseel Ali , Rabbani Unaib
Published: November 2021

Acceptance of COVID-19 vaccines needs a health promotion approach to address various social, environmental and personal factors leading to vaccine hesitancy. We assessed the vaccine hesitancy rate and applied social cognitive theory (SCT) to understand COVID-19 vaccine rejection in Qassim, Saudi Arabia. A cross-sectional study was conducted among visitors of 10 randomly selected primary health care centers in Buraidah, Saudi Arabia. Data was collected by a self-administrated questionnaire. The variables were grouped into six constructs of SCT. Logistic regression was used to assess the predictors of vaccine rejection. Out of 486 participants included in the study, 30.5% rejected the vaccine. The most common reason for vaccine rejection was uncertainty about the vaccine’s effectiveness (78%). Among various constructs of SCT, reciprocal determinism (nationality, income and suffering from COVID-19 infection), behavioral capability (knowledge about vaccine safety), self-efficacy (registered for vaccine), and observational learning (getting the vaccine after friends and family members) were significant predictors. Expectation and reinforcement constructs did not show significant association. There was high vaccine rejection in Qassim, KSA. This calls for further improving the mass education strategies. Social cognitive theory can be used to predict vaccine rejection and to develop strategies to increase the utilization of COVID-19 vaccines in Saudi Arabia.
Notice signs in food labeling
Authors: Nikolaeva M.A. , Smirnova E.V. , Smirnova A.A.
Published: November 2021

The article discusses notice signs as a new type of information signs, which include the "Traffic Light" labeling. The necessity of using these signs on the labeling is shown. It has been established that the widespread introduction of the "Traffic Light" notice sign into the production labeling will improve the information support of food buyers and increase their ability to make a competent choice of food products that provide healthy nutrition. As a result, consumers will be able to purchase groceries in stores that will improve the structure of the daily diet, taking into account the principles of healthy eating.
Analysis of the competitiveness of furniture industry enterprises
Authors: Pukhova V. M. , Ibragimova N. A.
Published: November 2021

The work is devoted to the analysis of the competitiveness of furniture industry enterprises producing cabinet furniture. In addition, a comparative analysis was carried out using a point-based assessment system and a competitiveness polygon was built.
Antihypertensive drug prescription trends in Shahrekord, Iran
Authors: Maghsoudi Ahmadreza , Dehghani Mobarakeh Maryam , Momeni Ali , Nematollahi Alireza , Asgari Shahin , Rasooli Laa'ya
Published: November 2021

Introduction: Hypertension is one of the most leading causes of death worldwide. It is an important risk factor for ischemic heart disease (IHD), chronic kidney disease (CKD) and cerebrovascular diseases. Objectives: The aim of the study was evaluation of the status of blood pressure control and trends in prescribed antihypertensive medication usage among hypertensive patients in Shahrekord, Iran. Patients and Methods: In a cross-sectional descriptive study 250 hypertensive patients were enrolled. The patients were evaluated based on the status of blood pressure (BP) control and the prescription trends and efficacy of antihypertensive drugs. The data were also evaluated in subgroups of diabetics or non-diabetics, smokers or non-smokers, patients with or without CKD, patients with or without IHD. Results: A total of 250 patients (149 women and 101 men) were enrolled in this study. The mean age of participants was 66.22±13.58 years. Mean systolic and diastolic BP were 143.4±29.4 mm Hg and 85.8±12.5 mm Hg respectively. Poor controlled BP was seen in 106 patients. The more common prescribed antihypertensive drugs were angiotensin receptor blockers (46%), diuretics (33.6%) and beta-blockers (32.8%). Conclusion: The study showed that most of the patients had poor controlled BP and physicians increasingly prescribe angiotensin receptor blockers.