bluuebunny/crossref_metadata_2025 huggingface dataset:
Fault-Block Platform Evolution between Late Cretaceous and Early Miocene along the Margin of the Latium-Abruzzi Carbonate Platform (Southern Prenestini Mountains, Central Apennines, Italy)
Authors: Brandano Marco , Cornacchia Irene , Catanzariti Rita
Published: September 2022

Since the origin of the carbonate platform concept, the reconstruction of the geometry and the evolution of the margin has been an intriguing topic. The Latium-Abruzzi platform is one of the largest shallow water domains of the Central Apennines, however, the reconstruction of the geometry and evolution of its margin has been classically problematic because the latter has been erased by the out-of-sequence Olevano-Antrodoco thrust system. The investigated area is placed in the Prenestini Mountains, the southernmost portion of the Sabina Domain, where a Cretaceous to Neogene carbonate succession, ascribed the Latium-Abruzzi platform margin, crops out. Stratigraphic and facies analyses showed a Late Cretaceous extensional stage that produced two main fault-block platforms, respectively, South Eastern Prenestini and South Western Prenestini platforms, developed westward of the large Latium-Abruzzi Platform domain. In these platforms, during the Paleocene–Eocene interval, pelagite deposition coincides with the main relative sea-level rise. Instead, during the following falling stage, the seafloor, consisting of the Cretaceous carbonate, was in the wave abrasion zone and the pelagic carbonate mud was swept away or trapped in local depressions or fractures (neptunian dykes), whereas the coarse sediment produced by the erosion of indented and fractured substrate formed polygenic conglomerate accumulation on the Cretaceuos carbonate platform substrate. Successively, an isolated homoclinal ramp, the Guadagnolo Fm, Aquitanian to Serravallian in age, developed on the drowned fault-block platforms, suggesting that during Neogene the articulation of the substrate of the two fault-block platforms had to be limited to host the bioclastic sedimentation of the Guadagnolo Fm and to allow the development of a carbonate ramp depositional profile.
Content Analysis of #Postpartumbody Images Posted to Instagram
Authors: Gow Megan L. , Jebeile Hiba , Lister Natalie B. , Roth Heike , Skouteris Helen , Bergmeier Heidi
Published: September 2022

Understanding the imagery on social media targeting postpartum women is an important step in determining the utility of Instagram as a potential avenue for targeting public health messages to this group. This study (1) describes the content of images on Instagram tagged with #postpartumbody and; (2) compares images from ‘Top’ posts (‘trending’ or ‘popular’) with ‘Recent’ posts. 600 images tagged with #postpartumbody (300 ‘Top’ and 300 ‘Recent’) were systematically captured from Instagram and coded using a predefined framework. Images of women were coded for adiposity, muscularity, pose and attire. Chi-square tests were used to compare ‘Top’ and ‘Recent’ posts. Most (n = 409) images were of a woman who generally had low/average adiposity (91%) and little-to-none/some visible muscle definition (93%). Most women (52%) were posing in a non-specific manner, 5% were posing to accentuate a postpartum body feature and 40% were wearing fitness attire. Compared with ‘Recent’, ‘Top’ posts were less likely to be text-focused (p < 0.001), photos of food (p < 0.001) or linked to a product/program (p < 0.001). Women of lower adiposity are more likely to post images of themselves on Instagram tagged with #postpartumbody than women of higher adiposity, which may reflect increased body pride in this group, but could reduce body satisfaction for some viewers. Conveying health information on Instagram may be necessary to interrupt potentially harmful content.
Investigation of Mental and Physical Health of Nurses Associated with Errors in Clinical Practice
Authors: Pappa Despoina , Koutelekos Ioannis , Evangelou Eleni , Dousis Evangelos , Gerogianni Georgia , Misouridou Evdokia , Zartaloudi Afroditi , Margari Nikoletta , Toulia Georgia , Mangoulia Polyxeni , Ferentinou Eftychia , Giga Anna , Dafogianni Chrysoula
Published: September 2022

Background: Errors are common among all healthcare settings. The safety of patients is linked directly with nursing errors because nurses stand by them more often than any other healthcare professional. The role of mental and physical health of nurses is of great interest for a good and efficient job performance, but also for maintaining good patient care delivery. This study aimed to investigate the association between nurses’ general health and making errors during clinical practice. Methods: A total of 364 nurses completed a specially designed questionnaire anonymously and voluntarily. The sample consisted of nurses with all educational degrees. The questionnaire included demographic data and questions about general health issues, resilience status and nurses’ possible experience with errors within a hospital. Results: 65,8% of the participants stated that at least one error had happened at their workplace, and 49,4% of them reported that the error was caused by them. Somatic symptoms were found to have a positive correlation with making errors (p < 0.001). However, the other aspects of general health, which were anxiety/insomnia, social dysfunction and severe depression, had no statistical significance with adverse events. The most common type of error reported (65,5%) was a medication adverse event. Resilience level was found to be statistically significant (p < 0.001) when correlated with all aspects of general health (anxiety/insomnia, severe depression, somatic symptoms), but not with social dysfunction. Conclusion: Nurses are affected by their somatic symptoms in their daily clinical practice, making them vulnerable to making errors that compromise patient safety. A high resilience level could help them cope with unfavorable situations and prevent them from doing harm to a patient or themselves.
Correction: Yeoh et al. Pericapsular Nerve Group Block and Iliopsoas Plane Block: A Scoping Review of Quadriceps Weakness after Two Proclaimed Motor-Sparing Hip Blocks. Healthcare 2022, 10, 1565
Authors: Yeoh Shang-Ru , Chou Yen , Chan Shun-Ming , Hou Jin-De , Lin Jui-An
Published: September 2022

In the original publication [...]
The Mediating Effects of Social Support on the Relationship between Uncertainty and Quality of Life among Patients with Chronic Low Back Pain: A Cross-Sectional Survey
Authors: Choi Jin-Won , So Wi-Young , Kim Kyoung-Mi
Published: September 2022

Background: This study aimed to investigate the mediating effects of social support on the relationship between uncertainty and quality of life (QOL) in patients with chronic low back pain (LBP). Methods: From 1 July 2019 to 25 March 2020, data were collected using a structured questionnaire from inpatients and outpatients > 20 years of age with chronic LBP lasting > 3 months. Inpatients included patients waiting for surgery and those recovering after surgery. The exclusion criteria were cancer and other serious pathological diseases. The relationships between uncertainty, social support, and QOL were analyzed using Pearson’s correlation coefficients. Results: Uncertainty, the independent variable, exerted a significant effect on social support, the mediator (B = 0.33, p < 0.001). In addition, both uncertainty (B = 0.37, p < 0.001) and social support (B = 0.45, p < 0.001) exerted statistically significant effects on QOL, the dependent variable. Conclusions: Disease-related uncertainty can reduce QOL in patients with chronic LBP, and this relationship is mediated by the level of social support. To develop strategies for strengthening social support from healthcare providers, family, and friends, future studies should examine the experiences of patients with chronic LBP from various perspectives, including pain intensity and duration.
Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review
Authors: Wang Chen , Shi Yiyun
Published: September 2022

Extramedullary hematopoiesis is rarely seen in patients with myelodysplastic syndromes, and its clinical characterizations are not well-defined. Here, we systematically reviewed the published literature to summarize the clinical manifestations, treatments, and long-term outcomes of biopsy-proven extramedullary hematopoiesis in patients with myelodysplastic syndromes. We included 41 patients, and ring sideroblasts were the most common myelodysplastic subtype (30.6%). Extramedullary hematopoiesis was typically symptomatic on presentation due to local compression, frequently involving the liver or spleen (36.6%), or the paravertebral region (24.4%). Notably, ring sideroblasts were predominantly seen in patients with non-hepatosplenic involvement (38.5 vs. 6.7%, p = 0.034). Interventions, when required, usually included surgery (36.8%) or radiation (13.2%), which led to symptomatic improvement in 55.5% of patients. The median overall survival of the current cohort was 7 months. The current study confirms the rarity of extramedullary hematopoiesis as a complication of myelodysplastic syndromes; however, its outcomes in response to systemic modern therapies require further investigation.
The WAS Project—Waterscape Archaeology in Sicily at Isola delle Femmine (PA, Italy): Submerged and Emerged Heritage
Authors: Bucci Giovanna
Published: September 2022

The WAS—Waterscape Archaeology in Sicily—project is dedicated to underwater cultural heritage mapping, knowledge and awareness of the cultural heritage, dissemination, and analysis of the submerged environment concerning the coast. The prototype investigation site presented here is Isola delle Femmine (PA, Italy). This paper highlights the archaeological discovery with a description of the main finds, across a multidisciplinary approach, carried out with low-cost technology, increasing sustainable diving, and underlining the relationship between submerged and open-air historical evidence. Our studies address the realization of new underwater archaeological itineraries connected to local history. This text provides a historical-archaeological introduction to understanding the context of the site and, with some geological notes, illustrates the phases of the research with a presentation of the main artifacts, with a focus on the methodology and the techniques of the surveys and the usefulness of underwater photogrammetry and 3D modeling with a particular focus on the tourism application in the diving centers. Our work has allowed for the creation of two new underwater archaeological itineraries of Sicily. The innovative aspects of our project are linked to a new holistic approach in the context of the scientific synergy between multiple disciplines.
An Example of Microwave Holography Investigation of an Old Orthodox Russian Icon Dated to 19th Century
Authors: Ivashov Sergey I. , Razevig Vladimir V. , Sergeev Dmitriy L. , Bugaev Alexander S. , Zhou Feng , Prokhanova Elena I. , Shcherbakova Anastasia V. , Dobrynin Sergey N. , Vasilenkov Maxim
Published: September 2022

The study, preservation and restoration of the cultural heritage objects of mankind are not only of great cultural importance but also have a significant economic component because cultural values of past centuries attract tourists from all over the world. The use of modern technical and scientific achievements in the field of non-destructive testing makes it possible to obtain new knowledge about cultural objects regarding their origin and dating, as well as to contribute to their better restoration and preservation. An important component of their use is additional opportunities to identify high quality fakes of original cultural objects that have historical significance. The capabilities of various non-destructive testing (NDT) methods used to examine cultural objects are characterized by their penetration depth, resolution, and sensitivity to material properties. Thus, in many cases, it is necessary to perform multi-sensor non-destructive testing and creating large data sets that require an efficient evaluation. This article considers an example of using microwave (MW) holographic sensors for the examining of an old Orthodox Russian Icon dated of the late 19th century. The paper describes the technology of microwave holography, which has recently been applied to the examination of art works. Unlike the well-studied X-ray method, MW holography makes it possible to examine objects with one-sided access. Its other advantages are the relative cheapness of the equipment and the safety of use due to the low level of radiation. The article describes a MW holograms reconstruction algorithm, as well as a method for improving the quality of obtained MW images. The data collected at MW research of the Icon are compared with the results of X-ray examination and confirmed by subsequent opening and visual examination performed by professional restorers.
Functional Characterization of Tea Plant (Camellia sinensis L.) CsCBF2 Gene Involved in Multiple Abiotic Stress Response in Tobacco (Nicotiana tabacum L.)
Authors: Zhou Qiying , Liu Dongxiao , Wei Yiwan , Ma Ning , Zhang Ruijiao , Zhang Zengya , Jiang Changjun , Yuan Hongyu
Published: September 2022

C-repeat binding factors/dehydration responsive element binding factors 1 (CBFs/DREB1s) are a small family of transcription factors that play important roles in plant resistance to various external stresses. However, functional characterization of tea plant (Camellia sinensis L.) CBF gene (CsCBF) was still seldom reported. Here, functional study of the cold-responsive CBF gene (CsCBF2) was done. Results showed that CsCBF2 had conserved AP2 DNA-binding domain and the typical PKK/RPAGRxKFxETRHP and DSAWR signature sequences of CBF/DREB1. Yeast one-hybrid and transcription activation assays revealed that the activation domain of CsCBF2 could activate the reporter gene expression, and the N terminal of CsCBF2 displayed an inhibitory effect. Although CsCBF2 was conserved to bind the C-repeat/dehydration-responsive element (CRT/DRE), intact CsCBF2 protein preferred the CRT cis element. Under normal growth conditions, CsCBF2-overexpressing tobacco plants (CsCBF2-OX) exhibited lighter green leaf color, growth retardation, and dwarfism. Smaller leaf of CsCBF2-OX was only seen in eight weeks after been sown in soil. Under cold, salinity, or drought stress, CsCBF2-OX displayed better growing with longer roots, heavier fresh weight, higher germination rate, and accumulated more proline and sugar contents, but lower electrolyte leakage. The results demonstrated that CsCBF2 enhanced plant tolerance to multiple abiotic stresses.
Higher Water Yield but No Evidence of Higher Flashiness in Tropical Montane Cloud Forest (TMCF) Headwater Streams
Authors: Nainar Anand , Mahali Maznah , Kamlun Kamlisa Uni , Besar Normah Awang , Majuakim Luiza , Justine Vanielie Terrence , Cleophas Fera , Bidin Kawi , Kuraji Koichiro
Published: September 2022

There have been conflicting findings on hydrological dynamics in tropical montane cloud forests (TMCFs)—attributed to differences in climate, altitude, topography, and vegetation. We contribute another observation-based comparison between a TMCF (8.53 ha; 1906 m.a.s.l.) and a tropical lowland rainforest (TLRF) (5.33 ha; 484 m.a.s.l.) catchment in equatorial Sabah, Malaysian Borneo. In each catchment, a 90° v-notch weir was established at the stream’s outlet and instrumented with a water-level datalogger that records data at 10-min intervals (converted to discharge). A nearby meteorological station records rainfall at the same 10-min intervals via a tipping bucket rain gauge connected to a datalogger. Over five years, 91 and 73 storm hydrographs from a TMCF and a TLRF, respectively, were extracted and compared. Various hydrograph metrices relating to discharge and flashiness were compared between the TMCF and TLRF while controlling for event rainfall, rainfall intensity, and antecedent moisture. Compared to the TLRF, storm-event runoff in the TMCF was up to 169% higher, reflecting the saturated conditions and tendency for direct runoff. Instantaneous peak discharge was also higher (up to 6.6x higher) in the TMCF. However, despite high moisture and steep topography, stream responsiveness towards rainfall input was lower in the TMCF, which we hypothesise was due to its wide and short catchment dimensions. Baseflow was significantly correlated with API20, API10, and API7. Overall, we found that the TMCF had higher runoff, but higher moisture condition alone may not be sufficient to govern flashiness.
Nitric Oxide Linked to mGluR5 Upregulates BDNF Synthesis by Activating MMP2 in the Caudate and Putamen after Challenge Exposure to Nicotine in Rats
Authors: Kim Jieun , Sohn Sumin , Kim Sunghyun , Choe Eun Sang
Published: September 2022

Nitric oxide (NO) linked to glutamate receptors in the caudate and putamen (CPu) regulates neuroadaptation after drug exposure. Matrix-metalloproteinase (MMP), a Ca2+-dependent zinc-containing endopeptidase, increases mature brain-derived neurotrophic factor (BDNF) synthesis after drug exposure in the brain. The present study determined that NO synthesis linked to metabotropic glutamate receptor subtype 5 (mGluR5) stimulation after challenge exposure to nicotine activates MMP, which upregulates BDNF synthesis in the CPu. Subcutaneous injection of challenge nicotine (1.0 mg/kg) after repeated injections of nicotine (1.0 mg/kg/day) for 14 days and 7 days of nicotine withdrawal increased MMP2 activity and BDNF expression in the CPu of rats. These increases were prevented by the bilateral intra-CPu infusion of the mGluR5 antagonist, MPEP (0.1 nmol/side), the IP3 receptor antagonist, xestospongin C (0.004 nmol/side) or the neuronal nitric oxide synthase (nNOS) and NO inhibitor, Nω-propyl (0.1 nmol/side) prior to the challenge nicotine. Furthermore, bilateral intra-CPu infusion of the MMP2 inhibitor, OA-Hy (1 nmol/side) prevented the challenge nicotine-induced increase in the expression of BDNF. These findings suggest that elevation of NO synthesis linked to mGluR5 potentiates BDNF synthesis via activation of MMP2 after challenge exposure to nicotine in the CPu of rats.
Structures and Anti-Inflammatory Evaluation of Phenylpropanoid Derivatives from the Aerial Parts of Dioscorea polystachya
Authors: Cai Baixiang , Cai Xinyin , Xu Tao , Wang Jutao , Yu Yang
Published: September 2022

Seven undescribed phenylpropanoid constituents, including three new bibenzyl derivatives (1–3) along with four new benzofuran stilbene derivatives (4–7), were isolated from the aerial parts of Dioscorea polystachya. The structures of these compounds were elucidated using a combination of spectroscopic analyses, including UV, IR, HRESIMS, 1D, and 2D NMR. Further, all the compounds were evaluated on the anti-inflammatory activity for their inhibition of nitric oxide (NO) production by RAW 264.7 macrophages cells, and some of them (1–3 and 6) displayed inhibitory activity with IC50 values in the range of 9.3–32.3 μM. Moreover, compound 3 decreased the expression of iNOS in Western blot analysis, suggesting compound 3 is mediated via the suppression of an LPS-induced NF-κB inflammasome pathway.
Semi-Empirical Calculation of Bodipy Aggregate Spectroscopic Properties through Direct Sampling of Configurational Ensembles
Authors: Usoltsev Sergey , Shagurin Artem , Marfin Yuriy
Published: September 2022

Efficient prediction of the aggregation-induced callback of organic chromophores for utilization in molecular sensorics is a desirable development goal in modern computational chemistry. Dye aggregates are complicated to study when utilizing conventional quantum chemistry approaches, since they are usually composed of too many atoms to be effectively analyzed, even with high-throughput parallel systems. Here, we present a successful attempt to develop a protocol to assess the spectroscopic changes happening in BODIPY dyes upon aggregation from the first principles utilizing extended tight-binding (XTB) and Zerner’s intermediate neglect of differential overlap (ZINDO) Hamiltonians. The developed sampling technique for aggregate configurational space scanning was found to be sufficient to both reproduce peculiarities and justify experimental data on the spectroscopic behavior of chromophore aggregates. The sTDA, sTD-DFT (GFN2-XTB) and CIS (ZINDO) approaches were assessed, and then sources of errors and benefits were outlined. Importantly, our goal was to keep any of the mentioned calculations within a computational cost feasible for a single workstation, whereas scaling was possible at any point in time. Finally, several aggregate structures were investigated in the external field to try to achieve distributions similar to the ones observed in the electrostatic potential of the air–water interface to assess the borderlines of practical applicability of the suggested scheme.
Angiogenesis in Disease
Authors: La Mendola Diego , Trincavelli Maria Letizia , Martini Claudia
Published: September 2022

Angiogenesis is a multi-step process by which new blood capillaries are formed starting from preexisting functional vessels [...]
New Insights into the Thermal Stability of 1-Butyl-3-methylimidazolium-Based Ionic Liquids
Authors: Belesov Artyom V. , Shkaeva Natalya V. , Popov Mark S. , Skrebets Tatyana E. , Faleva Anna V. , Ul’yanovskii Nikolay V. , Kosyakov Dmitry S.
Published: September 2022

One of the most promising applications of ionic liquids (ILs) with 1-butyl-3-methylimidazolium (bmim) cation is based on their unique ability to dissolve and fractionate lignocellulosic biomass, allowing for the development of green biorefining technologies. A complete dissolution of lignocellulose requires prolonged treatment at elevated temperatures, which can cause the partial degradation of ILs. In the present study, a combination of various analytical techniques (GC-MS, HPLC-HRMS, 2D-NMR, synchronous thermal analysis) was used for the comprehensive characterization of bmim acetate, chloride, and methyl sulfate degradation products formed at 150 °C during 6- and 24-h thermal treatment. A number of volatile and non-volatile products, including monomeric and dimeric alkyl substituted imidazoles, alcohols, alkyl amines, methyl and butyl acetates, and N-alkylamides, was identified. By thermal lability, ILs can be arranged in the following sequence, coinciding with the decrease in basicity of the anion: [bmim]OAc > [bmim]Cl > [bmim]MeSO4. The accumulation of thermal degradation products in ILs, in turn, affects their physico-chemical properties and thermal stability, and leads to a decrease in the decomposition temperature, a change in the shape of the thermogravimetric curves, and the formation of carbon residue during pyrolysis.
MicroRNA and Hemostasis Profile of Carotid Atherosclerosis
Authors: Raskurazhev Anton A. , Kuznetsova Polina I. , Shabalina Alla A. , Tanashyan Marine M.
Published: September 2022

Carotid atherosclerosis (CA) is an important risk factor for ischemic stroke. We described the miRNA and hemostasis profile of patients with moderate and advanced stages of carotid atherosclerosis and elucidated potential correlations with hemostatic activation. A prospective case-control study included 61 patients with evidence of carotid atherosclerosis (via ultrasound). The study population was divided into groups depending on the degree of carotid artery stenosis: 60% or more (advanced) and <60% (moderate). All patients underwent the following blood tests: general blood test, hemostatic parameters and microRNA. Extraction of microRNA was performed using Leukocyte RNA Purification Kit (NORGEN Biotec Corp., Thorold, ON, Canada); miRNA quantification was performed via RT-PCR. Statistical analysis was performed in R programming language (v. 4.1.0) using RSudio. MicroRNA expression profile was different depending on CA degree. MiR-33a-5p/3p levels were higher in patients with ≥60% carotid stenosis (42.70 and 42.45 versus 38.50 and 38.50, respectively, p < 0.05). Almost complete separation can be visualized with the levels of miR-126-5p: 9.50 in the moderate CA group versus 5.25 in the advanced CA (p < 0.001). MiR-29-5p was higher in the moderate CA group: 28.60 [25.50;33.05] than in advanced CA group: 25.75 [24.38;29.50] (p = 0.086); miR-29-3p was also higher in the moderate CA group: 10.36 [8.60;14.99] than in advanced CA group: 8.46 [7.47;10.3] (p = 0.001). By-group pairwise correlation analyses revealed at least three clusters with significant positive correlations in the moderate CA group: miR-29-3p with factors V and XII (r = 0.53 and r = 0.37, respectively, p < 0.05); miR-21-5p with ADAMTS13, erythrocyte sedimentation rate and D-dimer (r = 0.42, r = 0.36 and r = 0.44, respectively, p < 0.05); stenosis degree with miR-33a-5p/3p and factor VIII levels (r = 0.43 (both) and r = 0.62, respectively, p < 0.05). Hemostasis parameters did not reveal significant changes in CA patients: the only statistically significant differences concerned factor VIII, plasminogen and (marginally significant) ADAMTS-13 and protein C. Down-regulation of miR-126-5p expression has been identified as a promising biomarker of advanced carotid atherosclerosis with high specificity and sensitivity. Correlation cluster analysis showed potential interplay between miRNAs and hemostatic activation in the setting of carotid atherosclerosis.
Dual-Functional Nanofibrous Patches for Accelerating Wound Healing
Authors: Xia Dan , Liu Yuan , Cao Wuxiu , Gao Junwei , Wang Donghui , Lin Mengxia , Liang Chunyong , Li Ning , Xu Ruodan
Published: September 2022

Bacterial infections and inflammation are two main factors for delayed wound healing. Coaxial electrospinning nanofibrous patches, by co-loading and sequential co-delivering of anti-bacterial and anti-inflammation agents, are promising wound dressing for accelerating wound healing. Herein, curcumin (Cur) was loaded into the polycaprolactone (PCL) core, and broad-spectrum antibacterial tetracycline hydrochloride (TH) was loaded into gelatin (GEL) shell to prepare PCL-Cur/GEL-TH core-shell nanofiber membranes. The fibers showed a clear co-axial structure and good water absorption capacity, hydrophilicity and mechanical properties. In vitro drug release results showed sequential release of Cur and TH, in which the coaxial mat showed good antioxidant activity by DPPH test and excellent antibacterial activity was demonstrated by a disk diffusion method. The coaxial mats showed superior biocompatibility toward human immortalized keratinocytes. This study indicates a coaxial nanofiber membrane combining anti-bacterial and anti-inflammation agents has great potential as a wound dressing for promoting wound repair.
Dynamic Sustainable Processes Simulation to Study Transport Object Efficiency
Authors: Bondarenko Iryna , Severino Alessandro , Olayode Isaac Oyeyemi , Campisi Tiziana , Neduzha Larysa
Published: September 2022

The development of reliability theory has led to the setting of tasks requiring consideration of the efficiency and functional safety of technical objects of transport over the life cycle. The paper demonstrates the possibility of using the universal laws of elastic wave theory to describe natural phenomena occurring in complex dynamic systems, on the examples of solving issues arising in the interaction of rolling stock and the railway track. The accounting of the time component and the ability of elastic waves to propagate energy in time and space allowed considering any interaction process as a chain of processes, incidence-reflection-refraction of force impulses of interaction. Understanding the physics of dynamic processes that occur in objects while performing their intended functions allows developers to improve objects in such a way as to minimize their life cycle cost and maximize their ability to perform their intended functions under different operating conditions. In addition, it allows the expansion of existing methods and approaches to diagnostics of dynamic transport systems. All this is a base for making it possible to develop an innovative and effective tool for engineers and scientists to assess the impact of technosphere transport objects on human habitats.
A New Random Positioning Machine Modification Applied for Microgravity Simulation in Laboratory Experiments with Rats
Authors: Yotov Viktor V. , Marovska Jivka , Turiyski Valentin , Ivanov Stoil I.
Published: September 2022

The study presents a newly constructed modification of a random positioning machine (RPM) used in 3D-clinostat and in random mode. The main purpose is to provide an RPM animal model that uses up to four experimental animals simultaneously. In order to validate our RPM, the gravity dispersion and its magnitude are compared with the ones of a traditional machine. The results showed no crucial deviations in gravity dispersion and its time-averaged value in all sets of parameters. Furthermore, a posteriori stress tests are conducted on three Wistar male rats groups in order to estimate the level of stress from the setup. The social trait results suggest that the group exposed to our device has no increase in anxiety.
The Impact of Non-Invasive Ventilation on Sleep Quality in COPD Patients
Authors: Wollsching-Strobel Maximilian , Bauer Iris Anna , Baur Johannes Julian , Majorski Daniel Sebastian , Magnet Friederike Sophie , Storre Jan Hendrik , Windisch Wolfram , Schwarz Sarah Bettina
Published: September 2022

Background: Non-invasive ventilation (NIV) has been shown to be the most appropriate therapy for COPD patients with chronic respiratory failure. While physiological parameters and long-term outcome frequently serve as primary outcomes, very few studies have primarily addressed the impact of NIV initiation on sleep quality in COPD. Methods: This single-center prospective cohort study comprised NIV-naïve patients with COPD. All patients underwent polysomnographic evaluation both at baseline and at 3 months follow-up, accompanied by the assessment of health-related quality of life (HRQL) using the Severe Respiratory Insufficiency Questionnaire (SRI) and the Epworth Sleepiness Scale (ESS). A subgroup evaluation was performed to address the impact of comorbid obstructive sleep apnea syndrome (OSAS). Results: Forty-six patients were enrolled and twenty-five patients completed the follow-up period (66.7 ± 7.4 years). NIV resulted in an increase in slow-wave sleep (+2% (−3.5/7.5), p = 0.465) and rapid eye movement sleep (+2.2% (−1.0/5.4), p = 0.174), although no statistical significance could be detected. ESS (−1.7(−3.6/0.1), p = 0.066) also showed a positive trend. Significant improvements in the Respiratory Disturbance Index (RDI) (−12.6(−23.7/−1.5), p = 0.027), lung function parameters, transcutaneous PCO2 and the SRI summary scale (4.5(0.9/8), p = 0.016) were observed. Conclusion: NIV therapy does not decrease sleep quality and is even capable of improving HRQL, transcutaneous PaCO2, daytime sleepiness and RDI, and the latter especially holds true for patients with comorbid OSAS.
Three Different Types of Fat Grafting for Facial Systemic Sclerosis: A Case Series
Authors: Arena Antonio , Committeri Umberto , Maglitto Fabio , Salzano Giovanni , Dell’Aversana Orabona Giovanni , Vaira Luigi Angelo , Piombino Pasquale , Apolito Michela , De Fazio Gianluca Renato , Califano Luigi
Published: September 2022

Systemic sclerosis (SSc) is a heterogeneous, chronic connective tissue disease, characterized by skin fibrosis as well as vascular and visceral lesions. It can involve the lungs, heart, kidneys, gastrointestinal tract, and bones. The orofacial manifestations of SSc can cause functional, aesthetic, and social distress, resulting in significant psychological implications for the patients. In recent decades, fat grafting improved the aesthetic outcomes in terms of volume deficiency, contour asymmetry, and skin elasticity of the face thanks to the regenerative action of the stem cells contained within it. We describe five cases of a patient with SSc treated with fat grafting used to correct volume loss and facial elasticity of the lips and perioral region on the middle and lower third of the face. All the patients received regular postoperative checks at weeks 1 and 2. A multiple choice questionnaire was administered to assess the degree of tolerability of the procedure. The reliability of the questionnaire was evaluated by calculating the Cronbach alpha using the MedCalc Statistical Software version 20.113. The aim of our study is to describe three different types of fat grafting used to correct volume loss and restore facial elasticity of the lips and perioral region on the middle and lower third of the face.
A Multi-Strategy Framework for Coastal Waste Detection
Authors: Ren Chengjuan , Lee Sukhoon , Kim Dae-Kyoo , Zhang Guangnan , Jeong Dongwon
Published: September 2022

In recent years, deep learning has been widely used in the field of coastal waste detection, with excellent results. However, there are difficulties in coastal waste detection such as, for example, detecting small objects and the low performance of the object detection model. To address these issues, we propose the Multi-Strategy Deconvolution Single Shot Multibox Detector (MS-DSSD) based on DSSD. The method combines feature fusion, dense blocks, and focal loss into a state-of-the-art feed-forward network with an end-to-end training style. In the network, we employ feature fusion to import contextual information to boost the accuracy of small object detection. The dense blocks are constructed by a complex function of three concurrent operations, which can yield better feature descriptions. Then, focal loss is applied to address the class imbalance. Due to the lack of coastal waste datasets, data augmentation is designed to increase the amount of data, prevent overfitting of the model, and speed up convergence. Experimental results show that MS-DSSD513 obtains a higher mAP, of 82.2% and 84.1%, compared to the state-of-the-art object detection algorithms on PASCAL VOC2007 and our coastal waste dataset. The proposed new model is shown to be effective for small object detection and can facilitate the automatic detection of coastal waste management.
Neuromuscular Blockade in the Pre- and COVID-19 ARDS Patients
Authors: Tsolaki Vasiliki , Zakynthinos George E. , Papadonta Maria-Eirini , Bardaka Fotini , Fotakopoulos George , Pantazopoulos Ioannis , Makris Demosthenes , Zakynthinos Epaminondas
Published: September 2022

Acute respiratory distress syndrome (ARDS) accounts for a quarter of mechanically ventilated patients, while during the pandemic, it overwhelmed the capacity of intensive care units (ICUs). Lung protective ventilation (low tidal volume, positive-end expiratory pressure titrated to lung mechanics and oxygenation, permissive hypercapnia) is a non-pharmacological approach that is the gold standard of management. Among the pharmacological treatments, the use of neuromuscular blocking agents (NMBAs), although extensively studied, has not yet been well clarified. The rationale is to minimize the risk for lung damage progression, in the already-injured pulmonary parenchyma. By abolishing rigorous spontaneous efforts, NMBAs may decrease the generation of high transpulmonary pressures that could aggravate patients’ self-inflicted lung injury. Moreover, NMBAs can harmonize the patient–ventilator interaction. Recent randomized controlled trials reported contradictory results and changed the clinical practice in a bidirectional way. NMBAs have not been documented to improve long-term survival; thus, the current guidance suggests their use only in patients in whom a lung protective ventilation protocol cannot be applied, due to asynchrony or increased respiratory efforts. In the present review, we discuss the published data and additionally the clinical practice in the “war” conditions of the COVID-19 pandemic, concerning NMBA use in the management of patients with ARDS.
Tracing the Optimal Level of Political and Social Change under Risks and Uncertainties: Some Lessons from Ancient Sparta and Athens
Authors: Halkos George E. , Economou Emmanouil M. L. , Kyriazis Nicholas C.
Published: September 2022

The present paper is inspired by the notions of “financial risk” and “financial uncertainties” and transfers their basic reasoning to social science analysis; that is, it develops a theoretical analysis in order to explain social and political change. We know that the degree of social and political change depends on the set of established institutions in a society. Societies can face two extremes: volatility, e.g., rapid changes that lead to instability, which increases the risk of a system or regime collapsing, or rigidity, which does not permit necessary adaptation and change and thus may again increase the risk of the regime collapsing. Thus, an optimal (or ideal) point of change is between the two extremes, permitting change that is neither too sudden and fast nor too slow and inflexible. To illustrate this, we analyze two cases from ancient Greece: Sparta, as a society and state with too many institutional checks and balances that led to rigidity and collapse, and Athens, which in the 5th century BCE had an institutional setting with very limited checks and balances, which again led to near collapse until the late 5th century BCE, when new institutions that were related to some efficient checks and balances were introduced that enabled the state to survive in a world of changing circumstances and balances of power.
Temporal and Spatial Evolution and Driving Mechanism of Urban Ecological Welfare Performance from the Perspective of High-Quality Development: A Case Study of Jiangsu Province, China
Authors: He Shasha , Fang Bin , Xie Xue
Published: September 2022

Based on the concept of high-quality development, this paper constructs an urban ecological welfare evaluation framework, measures the urban ecological welfare performance in Jiangsu Province from 2005 to 2019 using a stochastic frontier production function model, and conducts a spatial and temporal divergence feature analysis, combining a spatial panel econometric model and a threshold panel regression model to explore the spatial effects and mechanisms of urban ecological welfare performance. The results show that: (1) The urban ecological welfare performance in Jiangsu province has been increasing every year, and the spatial divergence between north and south is significant, with the overall trend of southern Jiangsu > central Jiangsu > northern Jiangsu. (2) The differences in urban ecological welfare performance among the three regions are gradually decreasing, with the high values expanding and the low values decreasing, and the urban ecological welfare performance in northern Jiangsu Province is gradually approaching that in southern Jiangsu Province, and the urban ecological welfare performance level tends to be balanced. (3) There are significant negative spillover effects of industrial structure, city scale, and economic development level on urban ecological welfare performance, as well as significant threshold effects of innovation level, industrial structure, foreign trade dependence, and economic development, and significant differences in the degree of influence of urbanization on urban ecological welfare performance under different threshold variables. (4) The urbanization and economic development levels are the fundamental factors driving urban ecological welfare performance improvement. Industrial structure optimization, city scale, technological innovation, and foreign trade dependence positively contribute to urban welfare performance, and government financial pressure constrains the performance level improvement. In the future, a long-term mechanism for high-quality green development should be constructed, spatial spillover channels should be continuously improved, welfare thresholds should be effectively circumvented, and urban ecological welfare performance should be promoted in a concerted manner.
Models for the Economic Impacts of Forest Disturbances: A Systematic Review
Authors: Zhai Jun , Ning Zhuo
Published: September 2022

The frequency of forest disturbances has increased under intensifying climate changes, and the economic impacts of forest disturbances should receive more attention. This paper systematically reviews models of the economic impacts of forest disturbances and summarizes four commonly applied models, which are “with and without” analysis, equilibrium models, the intervention model, and the social welfare model. The advantages and disadvantages of these four models are presented and compared, and literature using these models is introduced. The review of the economic assessment of damage caused by forest disturbances is expected to provide insights for researchers in this field and useful information about economic losses, price dynamics, and welfare redistribution for policymakers.
A Research on Cohesion Hyperspectral Detection Model of Fine-Grained Sediments in Beichuan Debris Flow, Sichuan Province, China
Authors: Wang Qinjun , Xie Jingjing , Yang Jingyi , Liu Peng , Chang Dingkun , Xu Wentao
Published: September 2022

Cohesion is the main inter-controlled factor for the stability of fine-grained sediments in debris flow, and plays an important role in debris flow hazard early warning. At present, there is no cohesion rapid remote sensing detection model, which seriously affects the development of quantitative evaluation on debris flow stability. How to use remote sensing to quickly detect the cohesion of fine-grained debris has become an important scientific issue. Therefore, strengthening the research on the cohesion hyperspectral detection model, indicating its sensitive spectral bands, and establishing a quantitative model between cohesion and these bands are of great significance not only in discovering the stability mechanism, but also in quickly establishing the stability detection model for gully sediments. Taking the Beichuan debris flow as the study area, we carried out experiments on cohesion, cohesion influencing factors, and spectra. Firstly, six cohesion hyperspectral sensitive bands are indicated in red, near infrared portions of the electromagnetic spectrum, including 750, 1578, 1835, 2301, 2305, and 2309 nm; secondly, these bands discover the cohesion influencing factors. Band 750 nm indicates the characteristics of cohesion, effective internal friction angle, and permeability coefficient, while the other five bands indicate the characteristics of effective internal friction angle, density, and moisture; finally, a hyperspectral remote sensing detection model for the fine-grained sediments cohesion is established. With a correlation coefficient of 0.56, and p value less than 0.001, the model indicates that cohesion has a great significant correlation with the six bands. This not only provides sensitive bands for detecting cohesion of fine-grained sediments using remote sensing, but also provides a scientific basis for rapid detection of the fine-grained sediments’ stability in large areas.
Influence of 40% Cold Working and Annealing on Precipitation in AISI 316L Austenitic Stainless Steel
Authors: Bártová Katarína , Dománková Mária , Bárta Jozef , Pastier Peter
Published: September 2022

Intergranular corrosion is one of the most important processes affecting the behaviour of austenitic stainless steels. Factors such as steel chemical composition, the degree of prior deformation and the exposure temperature affect the degree of sensitisation. AISI 316L (0% CW) steel was annealed at 650 °C for 5, 10, 30, 100, 300 and 1000 h to analyse the influence of isothermal annealing on the precipitation of secondary phases. AISI 316L steel after 40% cold working and subsequent annealing at 650 °C for 1, 1.5, 2, 5 and 10 h was investigated. Time–temperature sensitisation (TTS) diagrams were created based on corrosion test (ASTM A 262, practice A) results. In the case of AISI 316L (0% CW), M23C6, chi and sigma phases precipitated at grain boundaries, and the Laves phase was mainly inside of the grains. In the case of AISI 316L (40% CW), sigma, chi, Laves and M23C6 were identified and precipitated mainly along the grain boundaries as well as on the shear bands within different annealing times. It was confirmed that the increase in the annealing time caused an increase in the amounts of secondary phases. Secondary phases in the equilibrium state were calculated using Thermo-Calc software.
Fabrication of Copper Matrix Composites Reinforced with Carbon Nanotubes Using an Innovational Self-Reduction Molecular-Level-Mixing Method
Authors: Ya Bin , Xu Yang , Meng Linggang , Zhou Bingwen , Zhao Junfei , Chen Xi , Zhang Xingguo
Published: September 2022

An innovational self-reduction molecular-level-mixing method was proposed as a simplified manufacturing technique for the production of carbon nanotube copper matrix composites (CNT/Cu). Copper matrix composites reinforced with varying amounts of (0.1, 0.3, 0.5 and 0.7 wt%) carbon nanotubes were fabricated by using this method combined with hot-pressing sintering technology. The surface structure and elemental distribution during the preparation of CNT/Cu mixing powder were investigated. The microstructure and comprehensive properties of the CNT/Cu composites were examined by metallography, mechanical and electrical conductivity tests. The results revealed that the CNT/Cu could be produced by a high temperature reaction at 900 degrees under vacuum, during which the carbon atoms in the carbon nanotubes reduced the divalent copper on the surface to zero-valent copper monomers. The decrease in the ratio of D and G peaks on the Raman spectra indicated that the defective spots on the carbon nanotubes were wrapped and covered by the copper atoms after a self-reduction reaction. The prepared CNT/Cu powders were uniformly embedded in the grain boundaries of the copper matrix materials and effectively hindered the tensile fracture. The overall characteristics of the CNT/Cu composites steadily increased with increasing CNT until the maximum at 0.7 wt%. The performance was achieved with a hardness of 86.1 HV, an electrical conductivity of 81.8% IACS, and tensile strength of 227.5 MPa.
Advanced Biofuels from ABE (Acetone/Butanol/Ethanol) and Vegetable Oils (Castor or Sunflower Oil) for Using in Triple Blends with Diesel: Evaluation on a Diesel Engine
Authors: Aguado-Deblas Laura , López-Tenllado Francisco J. , Luna Diego , Bautista Felipa M. , Romero Antonio A. , Estevez Rafael
Published: September 2022

From a technical and economic point of view, our aim is to provide viable solutions for the replacement of fossil fuels which are currently used in internal combustion diesel engines. In this research, two new biofuels composed of second-generation vegetable oils (SVO),used oil sunflower (SO) or castor oil (CO), and the ABE blend (acetone/butanol/ethanol) were evaluated. ABE is an intermediate product from the fermentation of carbohydrates to obtain bio-butanol. Besides, the ABE blend exhibits suitable properties as biofuel, such asvery low kinematic viscosity, reasonable energy density, low autoignition temperature, and broad flammability limits. Diesel/ABE/SVO triple blends were prepared, characterized and then, tested on a diesel engine, evaluating power output, consumption, and exhaust emissions. The power output was slightly reduced due to the low heating values of ABE blend. Also, engine consumed more fuel with the triple blends than with diesel under low engine loads whereas, at medium and high loads, the fuel consumption was very similar to that of diesel. Regarding exhaust gas emissions, soot wasnotably reduced, and nitrogen oxides (NOx) and carbon monoxide (CO2) emissions were lower or comparable to that of diesel, while the CO emissions increased. The use of these biofuels allows the replacement of high percentagesof diesel without compromising engine power and achievinga significant reduction in pollution emissions. Furthermore, a notable improvement in cold flow properties of the fuel blends is obtained, in comparison with diesel.