bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychosocial Dynamics and Mental well-Being of Modern Youth
Authors: Akkozhoeva A. , Adilbekuulu B.
Published: May 2024

A comprehensive study of psychosocial factors affecting the mental well-being of modern youth is being conducted. Focusing on family support, social networks, stress management strategies, cultural influences, educational factors, and socioeconomic status, the authors provide a comprehensive analysis highlighting the influence of each of these aspects. The results highlight the key role of family relationships and social connections in the formation of emotional stability, and also highlight the importance of cultural factors and education in the perception and support of mental health. The generalized findings of the article provide the basis for the development of targeted strategies to support the mental health of young people, taking into account the diversity of sociocultural contexts.
Social Rehabilitation of Persons with Various Forms of Dependence
Authors: Abrarova Z.
Published: May 2024

Various forms of addiction affect people's social functioning and also create a burden on society. These disorders contribute to medical or mental illness, disability and death due to accidents or illnesses caused or aggravated by substance use, or higher rates of suicidality, all of which impact society.
Potential effect of the non-neuronal cardiac cholinergic system on hepatic glucose and energy metabolism
Authors: Kurabayashi Atsushi , Iwashita Waka , Furihata Kaoru , Fukuhara Hideo , Inoue Keiji
Published: May 2024

The vagus nerve belongs to the parasympathetic nervous system, which is involved in the regulation of organs throughout the body. Since the discovery of the non-neuronal cardiac cholinergic system (NNCCS), several studies have provided evidence for the positive role of acetylcholine (ACh) released from cardiomyocytes against cardiovascular diseases, such as sympathetic hyperreactivity-induced cardiac remodeling and dysfunction as well as myocardial infarction. Non-neuronal ACh released from cardiomyocytes is believed to regulate key physiological functions of the heart, such as attenuating heart rate, offsetting hypertrophic signals, maintaining action potential propagation, and modulating cardiac energy metabolism through the muscarinic ACh receptor in an auto/paracrine manner. Moreover, the NNCCS may also affect peripheral remote organs (e.g., liver) through the vagus nerve. Remote ischemic preconditioning (RIPC) and NNCCS activate the central nervous system and afferent vagus nerve. RIPC affects hepatic glucose and energy metabolism through the central nervous system and vagus nerve. In this review, we discuss the mechanisms and potential factors responsible for NNCCS in glucose and energy metabolism in the liver.
Comparative transcriptomics revealed neurodevelopmental impairments and ferroptosis induced by extremely small iron oxide nanoparticles
Authors: Lyu Zhaojie , Kou Yao , Fu Yao , Xie Yuxuan , Yang Bo , Zhu Hongjie , Tian Jing
Published: May 2024

Iron oxide nanoparticles are a type of nanomaterial composed of iron oxide (Fe3O4 or Fe2O3) and have a wide range of applications in magnetic resonance imaging. Compared to iron oxide nanoparticles, extremely small iron oxide nanoparticles (ESIONPs) (∼3 nm in diameter) can improve the imaging performance due to a smaller size. However, there are currently no reports on the potential toxic effects of ESIONPs on the human body. In this study, we applied ESIONPs to a zebrafish model and performed weighted gene co-expression network analysis (WGCNA) on differentially expressed genes (DEGs) in zebrafish embryos of 48 hpf, 72 hpf, 96 hpf, and 120 hpf using RNA-seq technology. The key hub genes related to neurotoxicity and ferroptosis were identified, and further experiments also demonstrated that ESIONPs impaired the neuronal and muscle development of zebrafish, and induced ferroptosis, leading to oxidative stress, cell apoptosis, and inflammatory response. Here, for the first time, we analyzed the potential toxic effects of ESIONPs through WGCNA. Our studies indicate that ESIONPs might have neurotoxicity and could induce ferroptosis, while abnormal accumulation of iron ions might increase the risk of early degenerative neurological diseases.
Farmer perceptions, knowledge, and management of fall armyworm in maize production in Uganda
Authors: Odong Thomas Lapaka , Obongo Isaac , Ariong Richard , Adur Stella E. , Adumo Stella A. , Onen Denish Oyaro , Rwotonen Bob I. , Otim Michael H.
Published: May 2024

Spodoptera frugiperda (J.E. Smith), fall armyworm (FAW), a polyphagous Noctuid pest, was first reported in Uganda in 2016. Farmers were trained to identify and manage the pest, but there was a lack of information on farmer knowledge, perceptions and practices deployed to control it. Therefore, we conducted a survey to assess maize farmers’ knowledge, perceptions and management of the pest during the invasion. We interviewed 1,289 maize farmers from 10 maize-growing agro-ecological zones (AEZ) of Uganda using well-structured questionnaires. The data were analyzed using R version 4.2.3. The respondents faced many constraints, including pests, drought, poor soils and labor constraints. Among the pests, FAW was ranked by most (85%) of the respondents as the number one pest problem in maize, and some farmers reported having noticed it way back in 2014. By 2018, more than 90% of the farmers had seen or heard about FAW, and about 80% saw FAW in their fields. The most common FAW symptoms reported by maize farmers were windowing, near tunnel damage, and holes on the cobs. The developmental stages of FAW identified by farmers included eggs (10%), young larvae (78.7%), mature larvae (73.5%) and adult moths (6.7%). Insecticides were the major control tactic, although some farmers used plant extracts, hand-picking, sand, and ash. Farmers sourced information on FAW from various sources, including fellow farmers, radio/TV, extension agents, input dealers, print media, research and NGO extension. There is a need to package clear and uniform information for the farmers and to develop and promote a sustainable solution for FAW management, including harnessing biological control and cultural practices.
Local perspectives on marine ecotourism development in a water-insecure island region: the case of Bocas del Toro, Panama
Authors: Kim Abigael , Scott Cinda P. , Swartz Wilf
Published: May 2024

As a dimension of a blue economy, marine ecotourism should, in theory, not only increase economic viability and environmental sustainability but, most importantly, pursue socially equitable outcomes. In tropical and sub-tropical island regions, where substantial tourism development is often coupled with widespread strains on public infrastructure and services, including water access, there exists a need to better understand the expansion of this industry is felt at the community level; more importantly by individuals who are reliant on these infrastructures and services. Through a case study of the Bocas del Toro Archipelago, where water insecurity is becoming acute, we draw on and mobilize stories from local community members, alongside non-participant observations and document collection, to 1) document the experience of some community members with water insecurity and shortages, including how they perceive the roles played by the central government and marine ecotourism sector, and 2) examine how community members feel about how communities feel about policies and investment priorities of the central government regarding water insecurity, including the extent to which they view marine ecotourism development as undermining or promoting local needs. Our results underline the complex nature of marine ecotourism governance and infrastructure development outcomes in a resource-insecure island region, demonstrating that current issues are greatly impacted by historical and social underpinnings of neo-colonialism and systemic racism, misalignments of community vs. government development priorities, and eroded political trust, that shape local experiences with sustainable development and local residents’ perceptions of the ability of marine ecotourism to address issues of water insecurity. Moreover, while our focus is on the marine ecotourism industry, the significance of these findings contributes to a growing body of literature that places local experiences at the forefront of research into the implications of sustainable development in island regions.
Case report: Virtual reality-based arm and leg cycling combined with transcutaneous electrical spinal cord stimulation for early treatment of a cervical spinal cord injured patient
Authors: Chu Xiaolei , Liu Shuaiyi , Zhao Xiaoxuan , Liu Tao , Xing Zheng , Li Qingwen , Li Qi
Published: May 2024

Spinal cord injury is a condition affecting the central nervous system, causing different levels of dysfunction below the point of nerve damage. A 50-year-old woman suffered a neck injury as a result of a car accident. After undergoing posterior cervical C3–C6 internal fixation with titanium plates on one side and C7 lamina decompression, the patient, who had been diagnosed with C3–C7 cervical disk herniation and spinal stenosis causing persistent compression of the spinal cord, was transferred to the rehabilitation department. After implementing the combined therapy of Virtual Reality-based arm and leg cycling along with transcutaneous electrical stimulation of the spinal cord, the patients experienced a notable enhancement in both sensory and motor abilities as per the ASIA scores. The patient’s anxiety and depression were reduced as measured by the Hamilton Anxiety and Hamilton Depression Tests. As evaluated by the SCIM-III, the patient’s self-reliance and capacity to carry out everyday tasks showed ongoing enhancement, leading to the restoration of their functionality. Hence, the use of Virtual Reality-based arm and leg cycling along with transcutaneous electrical spinal cord stimulation has potential to positively impact function in patients with spinal cord injury. However, as this is a case report, the small number of patients and the fact that the intervention was initiated early after the injury, we were unable to separate the recovery due to the intervention from the natural recovery that is known to occur in the initial weeks and months after SCI. Therefore, further randomized controlled trials with a large sample size is necessary.
Research trends in lipid-lowering therapies for coronary heart disease combined with hyperlipidemia: a bibliometric study and visual analysis
Authors: Cheng Quankai , Sun Jingjing , Zhong Haicheng , Wang Ziming , Liu Chang , Zhou Sheng , Deng Jie
Published: May 2024

Background

Cardiovascular disease (CVD) poses a significant global health and economic challenge, with atherosclerosis being a primary cause. Over the past 40 years, substantial research has been conducted into the prevention and reversal of atherosclerosis, resulting in the development of lipid-lowering agents such as statins and fibrates. Despite the extensive literature and formulation of numerous therapeutic guidelines in this domain, a comprehensive bibliometric analysis of the current research landscape and trends has not been performed. This study aimed to elucidate the evolution and milestones of research into lipid-lowering treatments for coronary heart disease (CHD) in conjunction with hyperlipidemia through bibliometric analysis, offering insights into future directions for treatment strategies.

Methods

This study examined publications from 1986 to 2023 retrieved from the Web of Science database (Core Collection). Utilizing tools such as VOSviewer, Pajek, and CiteSpace, we analyzed publication and citation numbers, H-indexes, contributions by countries and institutions, authorship, journal sources, and keyword usage to uncover research trajectories and areas of focus.

Results

Our analysis of 587 publications revealed a recent surge in research output, particularly post-2003. The American Journal of Cardiology published the highest number of studies, with 40 articles, whereas Circulation received the highest number of citations (6,266). Key contributors included the United States, Japan, and China, with the United States leading in citation numbers and the H-index. Harvard University and Leiden University emerged as pivotal institutions, and Professors J. Wouter Jukema and Robert P. Giugliano were identified as leading experts. Keyword analysis disclosed five thematic clusters, indicating a shift in research towards new drug combinations and strategies, signaling future research directions.

Conclusion

The last 4 decades have seen a notable rise in publications on lipid-lowering therapies for CHD and hyperlipidemia, with the United States retaining world-leading status. The increase in international collaboration aids the shift towards research into innovative lipid-lowering agents and therapeutic approaches. PCSK9 inhibitors and innovative combination therapies, including antisense oligonucleotides and angiopoietin-like protein 3 inhibitors, provide avenues for future research, intending to maximize the safety and efficacy of treatment approaches.
Impacts of fertilization methods on Salvia miltiorrhiza quality and characteristics of the epiphytic microbial community
Authors: Gong Feng , He Chao , Li Xianen , Wang Kehan , Li Min , Zhou Xiangyun , Xu Minghui , He Xueli
Published: May 2024

Plant epiphytic microorganisms have established a unique symbiotic relationship with plants, which has a significant impact on their growth, immune defense, and environmental adaptation. However, the impact of fertilization methods on the epiphytic microbial community and their correlation with the yield and quality of medicinal plant was still unclear. In current study, we conducted a field fertilization experiment and analyzed the composition of epiphytic bacterial and fungal communities employing high throughput sequencing data in different organs (roots, stems, and leaves) of Salvia miltiorrhiza, as well as their correlation with plant growth. The results showed that fertilization significantly affected the active ingredients and hormone content, soil physicochemical properties, and the composition of epiphytic microbial communities. After fertilization, the plant surface was enriched with a core microbial community mainly composed of bacteria from Firmicutes, Proteobacteria, and Actinobacteria, as well as fungi from Zygomycota and Ascomycota. Additionally, plant growth hormones were the principal factors leading to alterations in the epiphytic microbial community of S. miltiorrhiza. Thus, the most effective method of fertilization involved the application of base fertilizer in combination with foliar fertilizer. This study provides a new perspective for studying the correlation between microbial community function and the quality of S. miltiorrhiza, and also provides a theoretical basis for the cultivation and sustainable development of high-quality medicinal plants.
Measuring relational wellbeing: construct validity in pre-COVID-Era UK; generalizability across COVID-lockdown-Era India, Greece, and UK
Authors: Gaines Stanley O. , Otermans Pauldy , Spanoudaki Maria , Aditya Dev , Chirenda Netsai
Published: May 2024

Aim

In the present studies, we examine the construct validity and criterion-related validity of a previously unpublished, eight-item measure of relational wellbeing.

Methods

First, in two pre-COVID-Era pilot studies within the UK (n’s = 207 and 146, respectively), results of exploratory factor analyses revealed that—with the possible exception of one item regarding close relationships—the items assessed individual differences along a single dimension (i.e., relational wellbeing), rather than two distinct dimensions (i.e., social connections and close relationships). Second, in an initial pre-COVID-Era main study within the UK (n = 192), results of confirmatory factor analyses provided support for the hypothesized one-dimensional factor pattern, although the same problematic item from the pilot studies continued to under-perform relative to the other seven items.

Findings

In a subsequent COVID-Lockdown-Era main study across India (n = 205), Greece (n = 354), and the UK (n = 390), results of confirmatory factor analyses established that—after omitting the same problematic item that had surfaced in the preceding studies—a one-dimensional factor pattern provided equally satisfactory fit for the three samples.

Original value

Although we had not set out to test a priori hypotheses regarding mean similarities or differences in relational wellbeing among our COVID-Lockdown-Era studies, results of an analysis of variance revealed that persons within the UK scored significantly lower in relational wellbeing than did persons in India or Greece.

Limitations

As noted above, one particular item repeatedly performed poorly in factor analyses; this item ideally should be dropped from the relational wellbeing scale in future research.
Status and influencing factors of returning to work 6 months after discharge from hospital with severe acute pancreatitis-a cross-sectional descriptive-analytical study in China
Authors: Yang Dengbi , Quan Mingtao , Xiao Xuan
Published: May 2024

Objective

To describe the return to work of patients with severe acute pancreatitis within 6 months after discharge, and to explore the influence of demographic, clinical, and psychosocial factors on their return to work.

Research design

Prospective 6 months follow-up study.

Setting

A third class hospital in Guizhou Province. Adult of severe acute pancreatitis(18-60years), with a job before admission, in the intensive care unit ≥ 24 h, were included.

Main outcome measures

To study return to work and influencing factors one, three and six months severe acute pancreatitis patients discharge. several measurements were used, including General Health Questionnaire (Demographic, disease-related, job-related and health behavior data), Readiness for Return-To-Work Scale and the Hospital Anxiety and Depression Scale.

Results

Forty-three severe acute pancreatitis patients were included in our study, with mean age 41.53 years. Twenty-nine (67.44%) patients returned to work within 6 months, and fourteen patients did not return to work. The status of Readiness for Return-To-Work Scale: fourteen severe acute pancreatitis patients who did not return to work were mainly in the precontemplation dimension and prepared for action-self-evaluative dimension both 5 cases (35.71%), and the 29 patients who had returned to work were in the Proactive maintenance stage. The study showed that the independent risk factors for returning to work in SAP patients were chronic disease (OR, 0.095; 95% CI [0.011-0.822]; p=0.008), sepsis (OR, 0.071; 95% CI [0.015-0.339]; p=0.009), low education level (OR, 2.905; 95% CI [0.969-8.710]; p<0.001), and anxiety and depression at 6 months (OR, 1.418; 95% CI [0.996-2.019]; p=0.004).

Conclusions

In conclusion, the return to work of patients with severe acute pancreatitis needs to be improved. Chronic diseases, sepsis, low level of education and higher degree of anxiety and depression at 6 months were important factors leading to their failure to return to work.
Health through the eyes of youths: a qualitative study
Authors: Ow Nikki , Zivanovic Rebecca , Tee Karen , Mathias Steve , Barbic Skye Pamela
Published: May 2024

Background

Emerging definitions of health have suggested a shift in focus to one’s ability to manage their health condition, function, and social determinants of health. The construct of health for youths with mental health and substance use disorders (MHSU) is complex and multi-dimensional with interplay between biological, behavioral, and social conditions. Expanding definitions of health is crucial in the measurement of health and evaluation of integrated youth services (IYS) systems for people with MHSU disorders. Hence, it is critical to understand the construct of health from the perspective of a young person living with a MHSU disorder.

Methods

This study was conducted using inductive thematic analysis. Three focus groups were conducted from July to August 2017.

Results

A total of 22 youths (17–24 years) took part in this study. Results showed that health is a multidimensional construct situated in the ecosystem of a person’s environment. Health can be understood from two macro themes: Individual health and Determinants of health. It consisted of physical health, mental health, day-to-day functioning, and being in control of your own health condition. Systemic and social factors were factors that influenced the state of health.

Conclusion

This study contributes to a conceptualization of good health in youth with MHSU disorders. This conceptualization can aid in the development of more accurate measures of health and functioning and the evaluation of mental health services for youth with MHSU.
Using a Leroux-prior-based conditional autoregression-based strategy to map the short-term association between temperature and bacillary dysentery and its attributable burden in China
Authors: Wang Jianping , Lu Kai , Wei Yuxin , Wang Wei , Zhou Yongming , Zeng Jing , Deng Ying , Zhang Tao , Yin Fei , Ma Yue , Shui Tiejun
Published: May 2024

Background

In China, bacillary dysentery (BD) is the third most frequently reported infectious disease, with the greatest annual incidence rate of 38.03 cases per 10,000 person-years. It is well acknowledged that temperature is associated with BD and the previous studies of temperature-BD association in different provinces of China present a considerable heterogeneity, which may lead to an inaccurate estimation for a region-specific association and incorrect attributable burdens. Meanwhile, the common methods for multi-city studies, such as stratified strategy and meta-analysis, have their own limitations in handling the heterogeneity. Therefore, it is necessary to adopt an appropriate method considering the spatial autocorrelation to accurately characterize the spatial distribution of temperature-BD association and obtain its attributable burden in 31 provinces of China.

Methods

A novel three-stage strategy was adopted. In the first stage, we used the generalized additive model (GAM) model to independently estimate the province-specific association between monthly average temperature (MAT) and BD. In the second stage, the Leroux-prior-based conditional autoregression (LCAR) was used to spatially smooth the association and characterize its spatial distribution. In the third stage, we calculate the attribute BD cases based on a more accurate estimation of association.

Results

The smoothed association curves generally show a higher relative risk with a higher MAT, but some of them have an inverted “V” shape. Meanwhile, the spatial distribution of association indicates that western provinces have a higher relative risk of MAT than eastern provinces with 0.695 and 0.645 on average, respectively. The maximum and minimum total attributable number of cases are 224,257 in Beijing and 88,906 in Hainan, respectively. The average values of each province in the eastern, western, and central areas are approximately 40,991, 42,025, and 26,947, respectively.

Conclusion

Based on the LCAR-based three-stage strategy, we can obtain a more accurate spatial distribution of temperature-BD association and attributable BD cases. Furthermore, the results can help relevant institutions to prevent and control the epidemic of BD efficiently.
Association of mental disorders with sepsis: a bidirectional Mendelian randomization study
Authors: Hu Yuanzhi , Xiong Zihui , Huang Pinge , He Wan , Zhong Minlin , Zhang Danqi , Tang Guanghua
Published: May 2024

Background

Substantial research evidence supports the correlation between mental disorders and sepsis. Nevertheless, the causal connection between a particular psychological disorder and sepsis remains unclear.

Methods

For investigating the causal relationships between mental disorders and sepsis, genetic variants correlated with mental disorders, including anorexia nervosa (AN), attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder (PD), posttraumatic stress disorder (PTSD), schizophrenia (SCZ), and tourette syndrome (TS), were all extracted from the Psychiatric Genomics Consortium (PGC). The causal estimates and direction between these mental disorders and sepsis were evaluated employing a two-sample bidirectional MR strategy. The inverse variance weighted (IVW) method was the primary approach utilized. Various sensitivity analyses were performed to confirm the validity of the causal effect. Meta-analysis, multivariable MR, and mediation MR were conducted to ensure the credibility and depth of this research.

Results

The presence of AN was in relation to a greater likelihood of sepsis (OR 1.08, 95% CI 1.02–1.14; p = 0.013). A meta-analysis including validation cohorts supported this observation (OR 1.06, 95% CI 1.02–1.09). None of the investigated mental disorders appeared to be impacted when sepsis was set as the exposure factor. Even after adjusting for confounding factors, AN remained statistically significant (OR 1.08, 95% CI 1.02–1.15; p = 0.013). Mediation analysis indicated N-formylmethionine levels (with a mediated proportion of 7.47%), cystatin D levels (2.97%), ketogluconate Metabolism (17.41%) and N10-formyl-tetrahydrofolate biosynthesis (20.06%) might serve as mediators in the pathogenesis of AN-sepsis.

Conclusion

At the gene prediction level, two-sample bidirectional MR analysis revealed that mental disorder AN had a causal association with an increased likelihood of sepsis. In addition, N-formylmethionine levels, cystatin D levels, ketogluconate metabolism and N10-formyl-tetrahydrofolate biosynthesis may function as potential mediators in the pathophysiology of AN-sepsis. Our research may contribute to the investigation of novel therapeutic strategies for mental illness and sepsis.
Effects of frequent assessments on the severity of suicidal thoughts: an ecological momentary assessment study
Authors: Chen Tengwei , Niu Lu , Zhu Jiaxin , Hou Xiaofei , Tao Haojuan , Ma Yarong , Silenzio Vincent , Lin Kangguang , Zhou Liang
Published: May 2024

Objective

In recent years, there has been a significant increase in research using ecological momentary assessment (EMA) to explore suicidal thoughts and behaviors (STBs). Meanwhile, concerns have been raised regarding the potential impacts of frequent and intense STBs assessments on the study participants.

Methods

From November 2021 to June 2023, a total of 83 adolescent and young adult outpatients (Mage = 21.0, SDage = 6.3, 71.1% female), who were diagnosed with mood disorders, were recruited from three psychiatric clinics in China. Smartphone-based EMA was used to measure suicidal thoughts three times per day at randomly selected times. We examined the change of suicidal thoughts in each measurement and within 1 day to evaluate potential adverse effects using Bayesian multilevel models.

Results

The 3,105 effective surveys were nested in 83 participants (median follow-up days: 14 days). The results of two-level models indicated that suicidal thoughts decreased during the monitoring period. However, this effect varied among different individuals in the two-level model.

Conclusion

Our findings did not support the notion that repeated assessment of suicidal thoughts is iatrogenic, but future research should continue to investigate the impact of frequent assessment on suicidal thoughts, taking into account individual differences and utilizing larger sample sizes.
Effects of a Tai Chi rehabilitation program implemented using a hybrid online and offline mode on oxidative stress and inflammatory responses in patients with coronary heart disease: a randomized controlled trial
Authors: Cui Meize , Wei Qiuyang , Li Yameng , Liu Mingyu , Sun Ligang , Liu Xinyi , Chen Zaihao , Fang Hui , Liu Linli , Fu Jiahao , Li Cuihan , Li Haojie , Ma Yuxin , Zhang Xing , Huang Yuerong , Li Lujia , Lyu Shaojun , Zhang Jianwei
Published: May 2024

Background

Coronary heart disease (CHD) is the leading cause of death in both developed and many developing countries. Exercise training is a fundamental component of cardiac rehabilitation programs for patients with CHD. This study aims to investigate the effects of a Tai Chi rehabilitation program, which is provided through a hybrid online and offline mode, on oxidative stress and inflammatory responses in patients with CHD.

Methods

A total of 34 patients with coronary heart disease were randomly assigned to two groups: an experiment group (n = 14, age 62.07 ± 9.076 years) and a control group (n = 20, age 61.90 ± 9.700 years). The experiment group underwent a 12-week Tai Chi cardiac rehabilitation program (TCCRP), while the control group followed a conventional exercise rehabilitation program (CERP) consisting of 1-h sessions, 3 times per week, for a total of 36 sessions. Participants were studied at baseline and post-intervention. The main assessments include the levels of Malondialdehyde (MDA), Superoxide dismutase (SOD), Tumor necrosis factor (TNF-α) and Interleukin-10 (IL − 10) in blood samples. Pearson correlation analysis was used, and the differences between the two groups were subsequently tested using two-way repeated ANOVA. Statistical significance was defined as a two-sided p-value of <0.05.

Results

The key finding of the study reveals that MDA was significantly reduced by 1.027 nmoL/mL. Additionally, the TCCRP showed significant improvements in SOD and IL-10, with values of 10.110 U/mL and 2.441 pg./mL, respectively. Notably, a significant positive correlation was found between SOD and IL-10 (r = 0.689, p = 0.006), while MDA showed a significant positive correlation with TNF-a (r = 0.542, p = 0.045). In contrast, the ECRP group only showed a significant improvement in SOD.

Conclusion

The study conducted a 12-week program on TCCRP, which utilized a hybrid online and offline model for individuals with coronary heart disease. The program showed promising results in alleviating oxidative stress and inflammation, possibly by regulating the balance between oxidative and antioxidative factors, as well as pro-inflammatory and anti-inflammatory factors.
Magnitude of self-harm and associated factors among postnatal mothers attending immunization clinics at public health facilities in Boneya Boshe Woreda, Western Ethiopia, 2023: institution-based cross-sectional study design
Authors: Wedajo Lema Fikadu , Hajure Mohammedamin , Abdu Zakir , Tesfaye Gebremeskel Mulatu , Workneh Yadeta Alemayehu , Gezimu Wubishet , Hussen Mustefa Adem , Gemeda Aman Dule , Teferi Sheleme Mengistu , Alemu Solomon Seyife
Published: May 2024

Background

Self-harm is a preventable, but a leading, cause of maternal morbidity and mortality all over the world, with a significant impact on healthcare systems.

Objective

To assess the magnitude of self-harm and associated factors among postnatal mothers attending immunization clinics.

Methods

An institution-based cross-sectional study was employed among postnatal mothers attending infant immunization clinics at public health facilities in Boneya Boshe Woreda, Western Ethiopia, 1 October to 30 October 2023. A pretested, face-to-face interviewer-administered structured questionnaire prepared by Kobo Toolbox was used to collect the data. Both bivariable and multivariable logistic regression analyses were done. The level of significance was declared at p-value <0.05 with a 95% CI.

Results

Among the 423 mothers enrolled in the study, 415 of them finally participated, at a response rate of 98.10%. The magnitude of self-harm was 12.53% (95% CI: 9.33, 15.73). Involvement of husband in maternity and child healthcare (AOR = 1.90; 95% CI: 1.12, 2.10), depression (AOR = 2.79; 95% CI: 2.14, 6.94), loneliness (AOR = 2.49; 95% CI: 1.15, 5.40), postpartum intimate partner violence (AOR = 2.15; 95% CI: 1.01, 4.54), average monthly income (AOR = 3.70; 95% CI: 2.17, 10.50), and postnatal care (AOR = 2.72; 95% CI: 1.28, 5.80) were significantly associated factors.

Conclusion and recommendations

The study sought a magnitude of self-harm that was slightly higher than the previous study conducted in the northern part of Ethiopia. Therefore, healthcare providers should focus on identified factors during postnatal care to overcome them. Similarly, the concerned body should develop an effective strategy based on the identified factors to pay attention to postnatal mothers.
The effectiveness of intervention measures on MERS-CoV transmission by using the contact networks reconstructed from link prediction data
Authors: Kim Eunmi , Kim Yunhwan , Jin Hyeonseong , Lee Yeonju , Lee Hyosun , Lee Sunmi
Published: May 2024

Introduction

Mitigating the spread of infectious diseases is of paramount concern for societal safety, necessitating the development of effective intervention measures. Epidemic simulation is widely used to evaluate the efficacy of such measures, but realistic simulation environments are crucial for meaningful insights. Despite the common use of contact-tracing data to construct realistic networks, they have inherent limitations. This study explores reconstructing simulation networks using link prediction methods as an alternative approach.

Methods

The primary objective of this study is to assess the effectiveness of intervention measures on the reconstructed network, focusing on the 2015 MERS-CoV outbreak in South Korea. Contact-tracing data were acquired, and simulation networks were reconstructed using the graph autoencoder (GAE)-based link prediction method. A scale-free (SF) network was employed for comparison purposes. Epidemic simulations were conducted to evaluate three intervention strategies: Mass Quarantine (MQ), Isolation, and Isolation combined with Acquaintance Quarantine (AQ + Isolation).

Results

Simulation results showed that AQ + Isolation was the most effective intervention on the GAE network, resulting in consistent epidemic curves due to high clustering coefficients. Conversely, MQ and AQ + Isolation were highly effective on the SF network, attributed to its low clustering coefficient and intervention sensitivity. Isolation alone exhibited reduced effectiveness. These findings emphasize the significant impact of network structure on intervention outcomes and suggest a potential overestimation of effectiveness in SF networks. Additionally, they highlight the complementary use of link prediction methods.

Discussion

This innovative methodology provides inspiration for enhancing simulation environments in future endeavors. It also offers valuable insights for informing public health decision-making processes, emphasizing the importance of realistic simulation environments and the potential of link prediction methods.
From acute food insecurity to famine: how the 2023/2024 war on Gaza has dramatically set back sustainable development goal 2 to end hunger
Authors: Hassoun Abdo , Al-Muhannadi Khawla , Hassan Hussein F. , Hamad Ahmed , Khwaldia Khaoula , Buheji Mohamed , Al Jawaldeh Ayoub
Published: May 2024

The widespread destruction and the devastating humanitarian toll caused by the ongoing war on Gaza have transformed this besieged Strip into a place of death and despair. This review will explore the implications of this war for food security, focusing on Sustainable Development Goal (SDG) 2, which seeks to fight malnutrition and food insecurity and achieve zero hunger by 2030. This work is based on a review of grey literature, such as reports from government and non-governmental agencies, as well as recent scientific journal publications. Our results show that the ongoing war on Gaza has exacerbated the already acute food insecurity that Gazans have been struggling with since the blockade was imposed in 2007. Restless bombardment and ground operations have damaged or even razed agricultural land and all food production infrastructure (such as bakeries, mills, and food processing facilities), destroying Gaza’s food system. Facing catastrophic levels of hunger, some families, especially in northern Gaza have recently been resorting to eating animal feed and weeds to survive. With the starvation of civilians being used as a method of warfare, many experts and human rights organizations argue that Gaza is now the world’s worst hunger crisis and its population is on the verge of famine, if not already there. Moreover, this unprecedented humanitarian crisis in Gaza could have significant consequences on global food security in its six pillars, jeopardizing the implementation of SDG 2. While international organizations are making efforts to mitigate the catastrophic food shortage and famine, more comprehensive and sustainable solutions are needed to address the root causes of food insecurity in Gaza and ensure that all residents have access to an adequate and nutritious diet.
The Gender Pay Gap in Academia: Evidence from the Beedie School of Business
Authors: Gordon Irene M. , Hrazdil Karel , Spector Stephen
Published: May 2024

We analyzed gender pay gap in academia using detailed performance data of all faculty members at the Beedie School of Business, Simon Fraser University, during 2012–2022. Although we initially observed a small average pay gap in favor of male academics, we found that female academics received higher remuneration compared to their male counterparts, once we controlled for research and teaching productivity, prior education and work experience, ethnicity, and various academic appointments. Our results provide an insight into possible sources of gender bias and highlight the need to control for teaching and research performance when investigating gender pay gaps.
Drivers for Clustering and Inter-Project Collaboration—A Case of Horizon Europe Projects
Authors: Benissa Takwa , Patil Anish
Published: May 2024

This paper investigates the drivers and dynamics of clustering and inter-project collaboration within the framework of the Horizon Europe and Horizon 2020 projects. Leveraging a survey-based approach, we examine key themes surrounding the perception of clustering, the willingness to share information under legal confidentiality, and motivations for engaging with partners from different projects. The survey instrument, implemented via Microsoft Forms, was distributed among the consortia of eight EU projects participating in the SOLID4B cluster. Notably, the questionnaire was meticulously crafted based on an in-depth analysis of the SOLID4B case and comprehensive discussions with project coordinators and communication and dissemination managers from all participating projects. These discussions aimed to establish a clear roadmap for the cluster, ensuring the questionnaire’s relevance and usefulness for all participants. Data analysis was conducted within the same platform, facilitating efficient data processing and visualization. Our findings reveal that a significant majority of respondents (48 out of 55) perceive clustering as a valuable asset, indicative of a positive shift in perspectives. Challenges related to confidentiality were addressed through nuanced insights, with respondents demonstrating a willingness to share routine best practices, significant breakthroughs, and deliverables within a legally protected framework. Furthermore, a robust majority (40 out of 55) expressed a keen interest in collaborative endeavors, underscoring a collective drive to extend activities beyond individual project boundaries. The study highlights the importance of clustering with other projects in maximizing the impact of the Horizon program, extending stakeholder networks, and sharing knowledge and achievements in research and innovation. These insights contribute to a deeper understanding of the motivations and challenges surrounding clustering and collaboration within the Horizon Europe and Horizon 2020 projects. Ultimately, the findings pave the way for informed strategies aimed at fostering a dynamic and interconnected research community.
Growth of White Leghorn Chicken Immune Organs after Long-Term Divergent Selection for High or Low Antibody Response to Sheep Red Blood Cells
Authors: Honaker Christa F. , Taylor Robert L. , Edens Frank W. , Siegel Paul B.
Published: May 2024

Long-term divergent selection from a common founder population for a single trait—antibody response to sheep erythrocytes 5 days post-injection—has resulted in two distinct lines of White Leghorn chickens with a well-documented difference in antibody titers: high (HAS)- and low (LAS)-antibody selected lines. Subpopulations—high (HAR)- and low (LAR)-antibody relaxed—were developed from generation 24 of the selected lines to relax selection. The objective of the current experiment was to determine if this long-term selection and relaxation of selection impacted the growth of two organs important to chicken immunity: the spleen and the bursa of Fabricius. Spleens and bursae were obtained from ten chickens per line at nine timepoints (E18, D0, D6, D13, D20, D35, D49, D63, and D91) throughout their rapid growth phase and presented as a percent of body weight. Significance was set at p ≤ 0.05. For the spleen, all lines consistently increased in size relative to body weight to D49, followed by a consistent decline. All lines had a similar growth pattern, but HAS spleens grew faster than LAS spleens. For the bursa, LAS was smaller than the other three lines as an embryo and also smaller than HAS through D63. In the selected lines, bursa weight peaked at D35, whereas the relaxed lines peaked at D49. By D91, there was no difference between lines. Artificial and natural selection, represented by the long-term selected and relaxed antibody lines, resulted in differences in the growth patterns and relative weights of the spleen and bursa of Fabricius.
Music and Emotions in Non-Human Animals from Biological and Comparative Perspectives
Authors: Zapata-Cardona Juliana , Ceballos Maria Camila , Rodríguez Berardo de Jesús
Published: May 2024

The effects of sound stimulation as a sensorial environmental enrichment for captive animals have been studied. When appropriately implemented for farm animals, it can improve welfare, health, and productivity. Furthermore, there are indications that music can induce positive emotions in non-human animals, similar to humans. Emotion is a functional state of the organism involving both physiological processes, mediated by neuroendocrine regulation, and changes in behavior, affecting various aspects, including contextual perception and welfare. As there is very limited information on non-human animals, the objective of this review is to highlight what is known about these processes from human biological and comparative perspectives and stimulate future research on using music to improve animal welfare.
Effects of Five Dietary Carbohydrate Sources on Growth, Glucose Metabolism, Antioxidant Capacity and Immunity of Largemouth Bass (Micropterus salmoides)
Authors: Qian Pengcheng , Liu Yan , Zhang Hao , Zhang Penghui , Xie Yuanyuan , Wu Chenglong
Published: May 2024

This study investigated the effects of glucose (GLU), tapioca starch (TS), gelatinized tapioca starch (GTS), potato starch (PS) and gelatinized potato starch (GPS) on growth and physiological responses in juvenile largemouth bass Micropterus salmoides. After 8 weeks, fish fed with starch diets had better weight gain and growth rates. Counts of red blood cells and monocytes were increased in the PS and GPS groups, compared to GLU group. Contents of serum triglyceride and total cholesterol were markedly elevated in the TS, PS and GPS groups. There were lower levels of serum glucose, insulin and cholecystokinin, and higher agouti-related peptide contents in the PS group compared to GLU group. PS and GPS could enhance glycolysis and TCA cycle by increasing their enzyme activities and transcriptional levels. Additionally, starch sources markedly heightened mRNA levels of key genes involved in the respiratory electron transport chain. Additionally, elevated mRNA levels of key antioxidant genes were shown in the TS and GTS groups. Moreover, TS and PS could promote immunity by upregulating transcriptional levels of the complement system, lysozyme and hepcidin. Taken together, starch exhibited better growth via increasing glycolysis and TCA cycle compared with GLU, and PS could improve antioxidant and immune capacities in largemouth bass.
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H2O2
Authors: Zhou Ning , Cao Yongqing , Luo Youwen , Wang Lihua , Li Ruiqing , Di Heshuang , Gu Tiantian , Cao Yun , Zeng Tao , Zhu Jianping , Chen Li , An Dong , Ma Yue , Xu Wenwu , Tian Yong , Lu Lizhi
Published: May 2024

Oxidative stress increases the apoptosis of intestinal epithelial cells and impairs intestinal epithelial cell renewal, which further promotes intestinal barrier dysfunction and even death. Extensive evidence supports that resveratrol and apigenin have antioxidant, anti-inflammatory, and antiproliferative properties. Here, we investigated the ability of these two compounds to alleviate diquat-induced jejunal oxidative stress and morphological injury, using the duck as a model, as well as the effects of apigenin on oxidative stress induced by H2O2 in immortalized duck intestinal epithelial cells (IDECs). Ducks were randomly assigned to the following four groups, with five replicates: a control (CON) group, a diquat-challenged (DIQ) group, a resveratrol (500 mg/kg) + diquat (RES) group, and an apigenin (500 mg/kg) + diquat (API) group. We found that serum catalase (CAT) activity and total antioxidant capacity (T-AOC) markedly reduced in the RES and API groups as compared to the DIQ group (p < 0.05); moreover, serum S superoxide dismutase (SOD) levels increased significantly in the API group as compared to the DIQ group (p < 0.05). In jejunal mucosa, the malondialdehyde (MDA) content in the RES and API groups decreased more than that in the DIQ group (p < 0.05). In addition, the jejunal expression levels of the NRF2 and GCLM genes in the RES and API groups increased notably compared with those in the DIQ group (p < 0.05); meanwhile, CAT activity in the RES and API groups was markedly elevated compared with that in the CON group (p < 0.05). In IDECs, apigenin significantly restrained the H2O2-mediated increase in MDA content and decrease in CAT levels (p < 0.05). Furthermore, apigenin increased the protein expression of p-NRF2, NRF2, p-AKT, and p-P38; downregulated that of cleaved caspase-3 and cleaved caspase-9; and reduced the ratio of Bax/Bcl-2 in H2O2-treated IDECs (p < 0.05). In conclusion, resveratrol and apigenin can be used as natural feed additives to protect against jejunal oxidative stress in ducks.
The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism
Authors: Zhang Yanli , Huang Jianfeng , Zhang Yaru , Jiang Fengjuan , Li Shengpeng , He Shuai , Sun Jiaojiao , Chen Dan , Tong Ying , Pang Qingfeng , Wu Yaxian
Published: May 2024

Radiation pneumonitis (RP) is a prevalent and fatal complication of thoracic radiotherapy due to the lack of effective treatment options. RP primarily arises from mitochondrial injury in lung epithelial cells. The mitochondrial-derived peptide MOTS-c has demonstrated protective effects against various diseases by mitigating mitochondrial injury. C57BL/6 mice were exposed to 20 Gy of lung irradiation (IR) and received daily intraperitoneal injections of MOTS-c for 2 weeks. MOTS-c significantly ameliorated lung tissue damage, inflammation, and oxidative stress caused by radiation. Meanwhile, MOTS-c reversed the apoptosis and mitochondrial damage of alveolar epithelial cells in RP mice. Furthermore, MOTS-c significantly inhibited oxidative stress and mitochondrial damage in MLE-12 cells and primary mouse lung epithelial cells. Mechanistically, MOTS-c increased the nuclear factor erythroid 2-related factor (Nrf2) level and promoted its nuclear translocation. Notably, Nrf2 deficiency abolished the protective function of MOTS-c in mice with RP. In conclusion, MOTS-c alleviates RP by protecting mitochondrial function through an Nrf2-dependent mechanism, indicating that MOTS-c may be a novel potential protective agent against RP.