bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlates of physical activity levels, muscle strength, working memory, and cognitive function in older adults
Authors: Li Shufan , Wang Peng , Cai Zhidong , Jiang Wanting , Xin Xin , Wang Xing , Zhou Xiaojing
Published: December 2023

Objective

To explore the relationship between physical activity level, muscle strength, working memory and cognitive function in older adults.

Methods

A cross-sectional research design was employed to recruit 120 older adults individuals aged 70 and above. Participants were asked to complete the International Physical Activity Questionnaire-Short Form and the Montreal Cognitive Assessment Scale. Data on variables such as grip strength and performance on the N-back task were collected. Data analysis involved the use of independent samples t-tests, χ2 tests, linear regression analysis, Pearson correlation analysis, and one-way analysis of variance (ANOVA).

Results

The detection rate of cognitive dysfunction in older adults was 53.211%; 1-back correct rate had an explanatory power of 11.6% for the cognitive function scores of older adults (R2 = 0.116, p < 0.001); grip strength showed a significant positive correlation with 1-back correct rate (r = 0.417, p < 0.001), and was significantly correlated with the 0-back response time (r = −0.478), 1 -back response time (r = −0.441) were significantly negatively correlated (p < 0.001); physical activity level was significantly positively correlated with grip strength (r = 0.559, p < 0.001), and the difference in grip strength among older adults with different physical activity levels was statistically significant (F = 19.685, p < 0.001).

Conclusion

Physical activity level, muscle strength, working memory, and cognitive function are closely related in older adults, and the relational pathway of physical activity → muscle strength → working memory → cognitive function may serve as a useful addition to promote the field of cognitive research in older adults. To identify and prevent cognitive decline in older adults, physical activity questionnaires, grip strength tests, and 1-back task tests can be extended to nursing homes and communities.
Peripherally derived myeloid cells induce disease-dependent phenotypic changes in microglia
Authors: Thougaard Estrid , Carney Brianna , Wlodarczyk Agnieszka , Brambilla Roberta , Lambertsen Kate Lykke
Published: December 2023

In central nervous system (CNS) injury and disease, peripherally derived myeloid cells infiltrate the CNS parenchyma and interact with resident cells, propagating the neuroinflammatory response. Because peripheral myeloid populations differ profoundly depending on the type and phase of injury, their crosstalk with CNS resident cells, particularly microglia, will lead to different functional outcomes. Thus, understanding how peripheral myeloid cells affect the phenotype and function of microglia in different disease conditions and phases may lead to a better understanding of disease-specific targetable pathways for neuroprotection and neurorepair. To this end, we set out to develop an in vitro system to investigate the communication between peripheral myeloid cells and microglia, with the goal of uncovering potential differences due to disease type and timing. We isolated peripheral myeloid cells from mice undergoing experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, or acute cerebral ischemia by permanent middle cerebral artery occlusion (pMCAO) at different times after disease and probed their ability to change the phenotype of primary microglia isolated from the brain of adult mice. We identified changes not only dependent on the disease model, but also on the timepoint after disease onset from which the myeloid cells were isolated. Peripheral myeloid cells from acute EAE induced morphological changes in microglia, followed by increases in expression of genes involved in inflammatory signaling. Conversely, it was the peripheral myeloid cells from the chronic phase of pMCAO that induced gene expression changes in genes involved in inflammatory signaling and phagocytosis, which was not followed by a change in morphology. This underscores the importance of understanding the role of infiltrating myeloid cells in different disease contexts and phases. Furthermore, we showed that our assay is a valuable tool for investigating myeloid cell interactions in a range of CNS neuroinflammatory conditions.
Serum neurofilament light chain levels in patients with cognitive deficits and movement disorders: comparison of cerebrospinal and serum neurofilament light chain levels with other biomarkers
Authors: Novobilský Richard , Bartova Petra , Lichá Karin , Bar Michal , Stejskal David , Kusnierova Pavlína
Published: December 2023

Background

Serum neurofilament light chain (S NfL) is a non-specific marker of neuronal damage, including Alzheimer’s disease (AD). We aimed to verify the reference interval (RI) of serum NfL using a highly sensitive ELISA, and to estimate the optimal cut-off value for neuronal damage. Our second objective was to compare NfL in cerebrospinal fluid (CSF) and serum (S) with the routine neurodegeneration biomarkers used in AD, and to assess their concentrations relative to the degree of cognitive deficit.

Methods

Samples from 124 healthy volunteers were used to estimate the S NfL RI. For the comparison study, we used CSF and S samples from 112 patients with cognitive disorders. Cognitive functions were assessed using the mini-mental state examination. ELISA assays were used to determine the CSF and S NfL levels, CSF β-amyloid peptide42 (Aβ42), CSF β-amyloid peptide40 (Aβ40), CSF total tau protein (tTau), CSF phosphorylated tau protein (pTau), and CSF alpha-synuclein (αS).

Results

The estimated RI of S NfL were 2.25–9.19 ng.L–1. The cut-off value of S NfL for assessing the degree of neuronal impairment was 10.5 ng.L–1. We found a moderate statistically significant correlation between S NfL and CSF Aβ42 in the group with movement disorders, without dementia (rs = 0.631; p = 0.016); between S NfL and CSF Aβ40 in the group with movement disorder plus dementia (rs = −0.750; p = 0.052); between S NfL and CSF tTau in the control group (rs = 0.689; p = 0.009); and between S NfL and CSF pTau in the control group (rs = 0.749; p = 0.003). The non-parametric Kruskal–Wallis test revealed statistically significant differences between S NfL, CSF NfL, CSF Aβ42, CSF tTau, and CSF pTau and diagnosis within groups. The highest kappa coefficients were found between the concentrations of S NfL and CSF NfL (κ = 0.480) and between CSF NfL and CSF tTau (κ = 0.351).

Conclusion

Our results suggested that NfL and tTau in CSF of patients with cognitive decline could be replaced by the less-invasive determination of S NfL using a highly sensitive ELISA method. S NfL reflected the severity of cognitive deficits assessed by mini-mental state examination (MMSE). However, S NfL is not specific to AD and does not appear to be a suitable biomarker for early diagnosis of AD.
Study on the influence mechanism of perceived benefits on unsafe behavioral decision-making based on ERPs and EROs
Authors: Zhang Shu , Yang Qiyu , Wei Cong , Shi Xiuzhi , Zhang Yan
Published: December 2023

Introduction

Perceived benefits are considered one of the significant factors affecting an individual’s decision-making process. Our study aimed to explore the influence mechanism of perceived benefits in the decision-making process of unsafe behaviors.

Methods

Our study used the “One Stimulus-Two Key Choice (S-K1/K2)” paradigm to conduct an EEG experiment. Participants (N = 18) made decisions in risky scenarios under high perceived benefits (HPB), low perceived benefits (LPB), and control conditions (CC). Time domain analysis and time-frequency analysis were applied to the recorded EEG data to extract ERPs (event-related potentials) and EROs (event-related oscillations), which include the P3 component, theta oscillations, alpha oscillations, and beta oscillations.

Results

Under the HPB condition, the theta power in the central (p = 0.016*) and occipital regions (p = 0.006**) was significantly decreased compared to the CC. Similarly, the alpha power in the frontal (p = 0.022*), central (p = 0.037*), and occipital regions (p = 0.014*) was significantly reduced compared to the CC. Under the LPB condition, theta power in the frontal (p = 0.026*), central (p = 0.028*), and occipital regions (p = 0.010*) was significantly reduced compared to the CC. Conversely, alpha power in the frontal (p = 0.009**), central (p = 0.012*), and occipital regions (p = 0.040*) was significantly increased compared to the HPB condition.

Discussion

The high perceived benefits may reduce individuals’ internal attention and evoke individuals’ positive emotions and motivation, leading individuals to underestimate risks. Consequently, they exhibited a greater inclination toward unsafe behaviors. However, the low perceived benefits may reduce individuals’ memory review, resulting in a simple decision-making process, and they are more inclined to make fast decisions to avoid loss. The research results can help to provide targeted intervention measures, which are beneficial to reducing workers’ unsafe behaviors.
Toward hippocampal volume measures on ultra-high field magnetic resonance imaging: a comprehensive comparison study between deep learning and conventional approaches
Authors: Lyu Junyan , Bartlett Perry F. , Nasrallah Fatima A. , Tang Xiaoying
Published: December 2023

The hippocampus is a complex brain structure that plays an important role in various cognitive aspects such as memory, intelligence, executive function, and path integration. The volume of this highly plastic structure is identified as one of the most important biomarkers of specific neuropsychiatric and neurodegenerative diseases. It has also been extensively investigated in numerous aging studies. However, recent studies on aging show that the performance of conventional approaches in measuring the hippocampal volume is still far from satisfactory, especially in terms of delivering longitudinal measures from ultra-high field magnetic resonance images (MRIs), which can visualize more boundary details. The advancement of deep learning provides an alternative solution to measuring the hippocampal volume. In this work, we comprehensively compared a deep learning pipeline based on nnU-Net with several conventional approaches including Freesurfer, FSL and DARTEL, for automatically delivering hippocampal volumes: (1) Firstly, we evaluated the segmentation accuracy and precision on a public dataset through cross-validation. Results showed that the deep learning pipeline had the lowest mean (L = 1.5%, R = 1.7%) and the lowest standard deviation (L = 5.2%, R = 6.2%) in terms of volume percentage error. (2) Secondly, sub-millimeter MRIs of a group of healthy adults with test–retest 3T and 7T sessions were used to extensively assess the test–retest reliability. Results showed that the deep learning pipeline achieved very high intraclass correlation coefficients (L = 0.990, R = 0.986 for 7T; L = 0.985, R = 0.983 for 3T) and very small volume percentage differences (L = 1.2%, R = 0.9% for 7T; L = 1.3%, R = 1.3% for 3T). (3) Thirdly, a Bayesian linear mixed effect model was constructed with respect to the hippocampal volumes of two healthy adult datasets with longitudinal 7T scans and one disease-related longitudinal dataset. It was found that the deep learning pipeline detected both the subtle and disease-related changes over time with high sensitivity as well as the mild differences across subjects. Comparison results from the aforementioned three aspects showed that the deep learning pipeline significantly outperformed the conventional approaches by large margins. Results also showed that the deep learning pipeline can better accommodate longitudinal analysis purposes.
Machine learning-based model for predicting inpatient mortality in adults with traumatic brain injury: a systematic review and meta-analysis
Authors: Wu Zhe , Lai Jinqing , Huang Qiaomei , Lin Long , Lin Shu , Chen Xiangrong , Huang Yinqiong
Published: December 2023

Background and objective

Predicting mortality from traumatic brain injury facilitates early data-driven treatment decisions. Machine learning has predicted mortality from traumatic brain injury in a growing number of studies, and the aim of this study was to conduct a meta-analysis of machine learning models in predicting mortality from traumatic brain injury.

Methods

This systematic review and meta-analysis included searches of PubMed, Web of Science and Embase from inception to June 2023, supplemented by manual searches of study references and review articles. Data were analyzed using Stata 16.0 software. This study is registered with PROSPERO (CRD2023440875).

Results

A total of 14 studies were included. The studies showed significant differences in the overall sample, model type and model validation. Predictive models performed well with a pooled AUC of 0.90 (95% CI: 0.87 to 0.92).

Conclusion

Overall, this study highlights the excellent predictive capabilities of machine learning models in determining mortality following traumatic brain injury. However, it is important to note that the optimal machine learning modeling approach has not yet been identified.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=440875, identifier CRD2023440875.
The dissociation of semantically congruent and incongruent cross-modal effects on the visual attentional blink
Authors: Zhao Song , Zhou Yuxin , Ma Fangfang , Xie Jimei , Feng Chengzhi , Feng Wenfeng
Published: December 2023

Introduction

Recent studies have found that the sound-induced alleviation of visual attentional blink, a well-known phenomenon exemplifying the beneficial influence of multisensory integration on time-based attention, was larger when that sound was semantically congruent relative to incongruent with the second visual target (T2). Although such an audiovisual congruency effect has been attributed mainly to the semantic conflict carried by the incongruent sound restraining that sound from facilitating T2 processing, it is still unclear whether the integrated semantic information carried by the congruent sound benefits T2 processing.

Methods

To dissociate the congruence-induced benefit and incongruence-induced reduction in the alleviation of visual attentional blink at the behavioral and neural levels, the present study combined behavioral measures and event-related potential (ERP) recordings in a visual attentional blink task wherein the T2-accompanying sound, when delivered, could be semantically neutral in addition to congruent or incongruent with respect to T2.

Results

The behavioral data clearly showed that compared to the neutral sound, the congruent sound improved T2 discrimination during the blink to a higher degree while the incongruent sound improved it to a lesser degree. The T2-locked ERP data revealed that the early occipital cross-modal N195 component (192–228 ms after T2 onset) was uniquely larger in the congruent-sound condition than in the neutral-sound and incongruent-sound conditions, whereas the late parietal cross-modal N440 component (400–500 ms) was prominent only in the incongruent-sound condition.

Discussion

These findings provide strong evidence that the modulating effect of audiovisual semantic congruency on the sound-induced alleviation of visual attentional blink contains not only a late incongruence-induced cost but also an early congruence-induced benefit, thereby demonstrating for the first time an unequivocal congruent-sound-induced benefit in alleviating the limitation of time-based visual attention.
Pharmacological interventions for lipid transport disorders
Authors: Neiman Aaron M.
Published: December 2023

The recent discovery that defects in inter-organelle lipid transport are at the heart of several neurological and neurodegenerative disorders raises the challenge of identifying therapeutic strategies to correct lipid transport defects. This perspective highlights two potential strategies suggested by the study of lipid transport in budding yeast. In the first approach, small molecules are proposed that enhance the lipid transfer activity of VPS13 proteins and thereby compensate for reduced transport. In the second approach, molecules that act as inter-organelle tethers could be used to create artificial contact sites and bypass the loss of endogenous contacts.
Dietary intake, nutritional adequacy and food sources of vitamins involved in the methionine-methylation cycle from Spanish children aged one to <10 years: results from the EsNuPI study
Authors: Partearroyo Teresa , Samaniego-Vaesken María de Lourdes , Rodríguez-Alonso Paula , Soto-Méndez María José , Hernández-Ruiz Ángela , Gil Ángel , Varela-Moreiras Gregorio
Published: December 2023

Background

Methionine-methylation cycle and the derived critical functions during infancy are key regulated by folates, vitamins B12, and B6. At present in Spain, there is an absence of studies that assess the intakes and dietary sources of total folates and B12 by children consuming all types of milks and those regularly consuming adapted milk formulas. Thus, our aim was to evaluate folates intakes alongside with vitamins B6 and B12 while describing their major dietary contributors in Spanish children aged one to <10 years.

Methods

A total of 1,448 children aged between 1 and 10 years (49.7% girls and 50.3% boys) from the EsNuPI, a prospective cross-sectional study, were allocated into two cohorts: one Spanish Reference Cohort (SRS) of the general population (n = 707), and another including children consuming adapted milks called Adapted Milk Consumers Cohort (AMS) (n = 741) completed two 24 h dietary recalls used to estimate their nutrient intakes and to compare them to the European Food Safety Authority (EFSA) Population Reference Intakes.

Results

The median intake of vitamin B6 was 1.35 (1.06–1.70) mg/day in the SRS and 1.45 (1.17–1.79) mg/day in the AMS, being significantly higher in the AMS for all age-groups. Prevalence of adequacy for vitamin B6 in the SRS and AMS was 97.7 and 98.7%, respectively. Total folates intakes in the AMS were significantly higher (p ≤ 0.001) in all age groups than in the SRS, independently of age. In addition, the prevalence of adequacy for folates intakes in all groups was more than 60%. Vitamin B12 intake increased with age independently of the type of milk consumed. The prevalence of adequacy for vitamin B12 was highly compliant by all population groups. The major contributors to vitamin B6 were milk and dairy products being significantly higher in AMS than SRS (p ≤ 0.001). The highest contributors to folates intakes were milk and dairy products, cereals, vegetables, and fruits in both groups whereas for vitamin B12 in the SRS sample were milk and dairy products followed by meat and meats products and for adapted milks, were milk and dairy products, followed by eggs, then meat and meats products.

Conclusion

A satisfactory prevalence of adequacy for vitamins B6, and B12 amongst the Spanish children population was observed, which was not the case for folates, regardless of the dietary group evaluated. Nevertheless, a possible strategy to increase folate intake among the youngest children is to increase the consumption of milk and dairy products within a healthier dietary pattern, as these may contribute significantly to the vitamin needs of the infant population.
Synthesis of chromium-D-phenylalanine complex and exploring its effects on reproduction and development in Drosophila melanogaster
Authors: Dhadde Shivsharan B. , Kalshetti Mallinath S. , Thippeswamy B. S.
Published: December 2023

The present study was undertaken to explore the effect of Chromium-D-phenylalanine (Cr (D-phe)3) on the reproduction and development of Drosophila melanogaster. Cr (D-phe)3 was synthesized and characterized by infrared spectral analysis, melting point (DSC), and UV spectral analysis. D. melanogaster was raised in corn flour agar medium containing 0, 5, 10, 15, and 20 μg/mL of Cr (D-phe)3. The effect of Cr (D-phe)3 was evaluated by observing the larval period, pupal period, percentage of egg hatching, morphometric analysis of eggs, larvae, pupae and adults, fertility, fecundity, lifespan of the emerged flies, and levels of antioxidant enzymes such as catalase, glutathione-S-transferase (GST), and superoxide dismutase (SOD) in the supernatant of flies homogenate suspension. The study results indicate that Cr (D-phe)3 showed beneficial effects on reproduction and development in D. melanogaster. Cr (D-phe)3 significantly improved the larval period, pupal period, percentage of egg hatching, morphometric characters of the larva, pupa, and adult, fertility, fecundity, and lifespan of D. melanogaster. Moreover, Cr (D-phe)3 also significantly elevated the levels of catalase (p < 0.01), GST (p < 0.05), and SOD (p < 0.01) in D. melanogaster, and results were statistically significant at the dose of 15 μg/mL. The study results indicate that Cr (D-phe)3 has a positive effect on the reproduction and development of D. melanogaster. The literature review revealed that there is a strong relationship between the physiology of metabolism, oxidative stress and reproduction and development. Several studies propose that Cr(III) influences insulin sensitivity and thereby the metabolism of carbohydrates, proteins, and fats. Cr (D-phe)3 also has antioxidant and anti-inflammatory properties. Hence, the observed beneficial effects of Cr (D-phe)3 on reproduction and development of D. melanogaster may be attributed to its physiological effect on carbohydrate, protein, and lipid metabolism and its antioxidant and anti-inflammatory properties.
PGF2α induces a pro-labour phenotypical switch in human myometrial cells that can be inhibited with PGF2α receptor antagonists
Authors: Hamshaw Isabel , Straube Anne , Stark Richard , Baxter Laura , Alam Mohammad T. , Wever Walter J. , Yin Jun , Yue Yong , Pinton Philippe , Sen Aritro , Ferguson Gregory D. , Blanks Andrew M.
Published: December 2023

Preterm birth is the leading cause of infant morbidity and mortality. There has been an interest in developing prostaglandin F2α (PGF2α) antagonists as a new treatment for preterm birth, although much of the rationale for their use is based on studies in rodents where PGF2α initiates labour by regressing the corpus luteum and reducing systemic progesterone concentrations. How PGF2α antagonism would act in humans who do not have a fall in systemic progesterone remains unclear. One possibility, in addition to an acute stimulation of contractions, is a direct alteration of the myometrial smooth muscle cell state towards a pro-labour phenotype. In this study, we developed an immortalised myometrial cell line, MYLA, derived from myometrial tissue obtained from a pregnant, non-labouring patient, as well as a novel class of PGF2α receptor (FP) antagonist. We verified the functionality of the cell line by stimulation with PGF2α, resulting in Gαq-specific coupling and Ca2+ release, which were inhibited by FP antagonism. Compared to four published FP receptor antagonists, the novel FP antagonist N582707 was the most potent compound [Fmax 7.67 ± 0.63 (IC50 21.26 nM), AUC 7.30 ± 0.32 (IC50 50.43 nM), and frequency of Ca2+ oscillations 7.66 ± 0.41 (IC50 22.15 nM)]. RNA-sequencing of the MYLA cell line at 1, 3, 6, 12, 24, and 48 h post PGF2α treatment revealed a transforming phenotype from a fibroblastic to smooth muscle mRNA profile. PGF2α treatment increased the expression of MYLK, CALD1, and CNN1 as well as the pro-labour genes OXTR, IL6, and IL11, which were inhibited by FP antagonism. Concomitant with the inhibition of a smooth muscle, pro-labour transition, FP antagonism increased the expression of the fibroblast marker genes DCN, FBLN1, and PDGFRA. Our findings suggest that in addition to the well-described acute contractile effect, PGF2α transforms myometrial smooth muscle cells from a myofibroblast to a smooth muscle, pro-labour–like state and that the novel compound N582707 has the potential for prophylactic use in preterm labour management beyond its use as an acute tocolytic drug.
Understanding alcohol use and changes in drinking habits among people with a severe mental illness: a qualitative framework analysis study
Authors: Puddephatt Jo-Anne , Makin Harriet , Gage Suzanne H. , Jones Andrew , Goodwin Laura
Published: December 2023

Introduction

Individuals with a severe mental illness (SMI) are more likely to drink at harmful levels or abstain. While it is known that drinking patterns change over time, the reasons for this among those with a SMI are unclear. This study aimed to (i) explore the experiences with alcohol, particularly in relation to mental health symptoms, and (ii) how drinking patterns have changed over time, among individuals who have a SMI diagnosis, who either currently drink alcohol or no longer drink.

Methods

One-to-one semi-structured telephone interviews were conducted to address the study aims. Current drinkers’ alcohol use was assessed using the Alcohol Use Disorder Identification Test. A framework analysis was used to address the study aims with a specific focus on the differences in the experiences with alcohol use between current and former drinkers.

Results

16 participants were interviewed, and five themes were developed. The analysis highlighted how alcohol was increasingly used to cope with (i) trauma, (ii) SMI-related symptoms, or (iii) stress. Among those with a SMI, non-drinking was facilitated through declines in SMI-related symptoms, previous negative consequences due to alcohol and changing the social environment. Current drinking habits were facilitated through changes in the reasons for drinking and adopting different alcohol moderation techniques.

Discussion

Among those with a SMI diagnosis and who either currently drink alcohol or no longer drink, our findings support the self-medication hypothesis and drinking motives model. However, our findings indicate the need for further development of drinking to cope with a focus on symptoms of a SMI and trauma. Our findings also have implications on specialist alcohol and mental health services, the need to improve individuals’ understanding of SMI, and the need to identify reasons for drinking among those with a recent diagnosis of a SMI.
The influence of the five-factor model of personality on performance in competitive sports: a review
Authors: Shuai Ying , Wang Shaoshen , Liu Xian , Kueh Yee Cheng , Kuan Garry
Published: December 2023

Personality is considered to be a factor affecting athletic performance. However, inconsistency in the research results regarding size and even direction of the relationship. An evaluation of the evidence of the relationship between personality and athletic performance was conducted in order to summarize the evidence available. A systematic literature search was conducted in March 2023. Sport performance and the Big Five personality model were identified in our research. We used PubMed, Web of Science, Embase, Cochrane Library, Wang Fang (Chinese), Wei Pu (Chinese), and CNKI (Chinese) databases for the systematic literature search (Prospero registration number: CRD42022364000), screened 4,300 studies, and found 23 cross-sectional studies eligible for inclusion in this review. The results of this systematic analysis show that, besides neuroticism, openness, conscientiousness, extraversion, and agreeableness are all positively correlated with sports performance. Conscientiousness and extraversion are the two main personalities in team sports. Openness and agreeableness show different results in different sports, and it is not clear to which project they are beneficial. The value of personality as a possible predictor of athletic performance is generally positive. Therefore, professionals such as applied sports psychologists, coaching personnel, athletes, and sports administrators must comprehensively grasp the significance of personality’s role in achieving success in major competitions. Considering these facts, sports practitioners should promote personality screening and personality development programs.
Online identity work dynamics of Instagram micro-influencers: an extreme case approach
Authors: Bergs Yoy , Peters Pascale , Lub X. D. , Blomme R. J.
Published: December 2023

Background

Advanced media technologies have become an integral part of people's daily lives, providing them with new tools and environments for the formation and enactment of their identities. To date, the literature acknowledges that media technologies, such as social networking sites, are used to form and enact online identities, and that these platforms can simultaneously pose challenges to individuals' identity work. However, we know little about the precise online identity work strategies that individuals employ in response to the challenges they face over time.

Objective

This paper examines the online identity work dynamics of Instagram micro-influencers, for whom social network sites enable and guide them in forming and enacting their online identities on a daily basis. The study was guided by the following research question: what are the challenges that Instagram micro-influencers perceive online and what are the online identity work strategies that they employ in response to these challenges over time?

Methods

This study employs an extreme case approach to rigorously explore the lives of seven micro-influencers on Instagram. We combine in-depth data from narrative interviews, longitudinal data from online autobiographical narratives revealed through the participants' Instagram timelines, and follow-up interviews.

Results

Our analysis revealed three main themes that highlight the challenges that Instagram micro-influencers face online: (1) amplified social expectations, (2) feelings of inauthenticity, and, as a result thereof, (3) psychological distress. We found that these challenges were viewed as catalysts for their online identity work processes. We identified three key online identity work strategies that the Instagram micro-influencers employed in response over time: (1) experimenting with their online identities, followed by either (2) segmenting between their online and offline identities, or (3) adding identities through online multiplicity.

Conclusion

Our research provides new insights into how individuals may respond to the challenge of managing their online identities over time by engaging in different online identity work strategies. This study highlights the importance of designing online media technologies that enable individuals to cope with online challenges. We emphasize the need to design online spaces for (1) the expression of authentic identities, (2) community building, and (3) online multiplicity.
Validity and reliability of the Arabic version of knowledge, attitudes, and practices toward COVID-19 preventative behaviors (KAP COVID-19)
Authors: Bajamal Eman , Alanazi Mona
Published: December 2023

Background

Even though the innovation of COVID-19 vaccination effectively protects against the virus, practicing preventative behaviors is still essential. However, public adherence to preventive behaviors relies mainly on the individuals’ knowledge, attitudes, and practices (KAP) toward COVID-19 preventative behaviors. Therefore, it is crucial to evaluate these aspects. Nevertheless, there is no validated scale that assesses KAP toward COVID-19 preventative behaviors. To evaluate the psychometric properties of the Arabic version of knowledge, attitudes, and practices toward coronavirus disease 2019 (COVID-19) preventative behaviors.

Methods

A quantitative descriptive cross-sectional design was used to develop and evaluate the psychometric properties of KAP through specific stages: item development, face, content, convergent and construct validity evaluation, and internal consistency. Data were collected online through “google forms” from June 2020 to July 2020. Both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to assess the construct validity.

Results

A total of 1,363 participants completed the scale. The overall Cronbach’s alpha was 0.83, indicating good internal consistency. Exploratory factor analysis supported structural validity for all the scale items with KMO 0.78, 0.60, and 0.81, respectively, and Bartlett’s Test of Sphericity = (p < 0.05). Convergent validity was confirmed by a moderate correlation between the KAP scale items, knowledge ranging from r = 0.11 (p < 0.01) to r = 0.62 (p < 0.01), attitude ranging from r = 0.158 (p < 0.01) to r = 0.584 (p < 0.01), and practice ranging from r = 0.383 (p < 0.01) to r = 0.774 (p < 0.01).

Conclusion

The psychometric properties of the scale indicate that the KAP is a valid and reliable scale that can be utilized to evaluate the level of KAP toward COVID-19 preventative behaviors among the population in Saudi Arabia.
Health economics aspects of kidney transplantation in Sicily: a benchmark analysis on activity and estimated savings
Authors: Cacciola Roberto , Leonardis Francesca , Gitto Lara , Favi Evaldo , Gruttadauria Salvatore , Clancy Marc , Veroux Massimiliano , Angelico Roberta , Pagano Duilio , Mazzeo Carmelo , Cacciola Irene , Santoro Domenico , Toti Luca , Tisone Giuseppe , Cucinotta Eugenio
Published: December 2023

Background

International and national registries consistently report substantial differences in kidney transplant (KT) activity despite demonstrable clinical and financial benefits. The study aims to estimate the financial resources gained by KT and produce a benchmark analysis that would inform adequate strategies for the growth of the service.

Methods

We analyzed the KT activity in our region between 2017 and 2019. The benchmark analysis was conducted with programs identified from national and international registries. The estimate of financial resources was obtained by applying the kidney transplant coefficient of value; subsequently, we compared the different activity levels and savings generated by the three KT programs.

Findings

The KT activity in the region progressively declined in the study years, producing a parallel reduction of the estimated savings. Such savings were substantially inferior when compared to those generated by benchmark programs (range €18–22 million less).

Interpretation

The factors influencing the reduced KT activity in the study period with the related “foregone savings” are multiple, as well as interdependent. Organ donation, access to the transplant waiting list, and KT from living donors appear to be the most prominent determinants of the observed different levels of activities. International experience suggests that a comprehensive strategy in the form of a “task force” may successfully address the critical areas of the service reversing the observed trend. The financial impact of a progressively reduced KT activity may be as critical as its clinical implications, jeopardizing the actual sustainability of services for patients with end-stage kidney disease.
Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil
Authors: Martins Amanda Friaes , Santos Aline Souza Espindola , Moreira Josino Costa , Câmara Volney de Magalhaes , Asmus Carmen Ildes Rodrigues Froes , Rosa Ana Cristina Simoes , Vineis Paolo , Meyer Armando
Published: December 2023

Background

Pyrethroids are commonly used insecticides in Brazil. Gestational and early childhood exposure to pyrethroids has been linked to adverse health effects, including neurodevelopmental delays, behavioral issues, and endocrine disruption. This study evaluated the exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil.

Methods

Creatinine-adjusted levels of the pyrethroid metabolites 3-phenoxy benzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzyl acid (4-FPBA) were measured in the urine of 142 pregnant women and their children at birth and in the first, third, and 6th months of life.

Results

The geometric mean (GM) and 95% confidence interval (95% CI) of 3-PBA and 4-FPBA urinary concentrations in pregnant women were 0.50 (0.37–0.67) and 0.37 (0.05–2.90) ng/mg, detected in 47.2 and 10.6%, respectively. Urinary concentrations of 3-PBA in the children were 0.18 (0.15–0.23) ng/mg at birth, 0.36 (0.08–1.56) ng/mg at 1-month-old, 0.68 (0.36–1.27) ng/mg at 3-month-old, and 1.36 (0.77–2.42) ng/mg at 6-month-old, and the detection rates were respectively 10.8, 9.4, 20.9, and 20.7%.

Discussion

This study is one of the few that has evaluated the urinary concentrations of pyrethroids in newborns and children in their 1st year of life. The results of this study show that children's exposure to pyrethroids significantly increases after birth.
The unwritten rules and HIV: a qualitative study of informal institutions and HIV vulnerability among workers at social venues in Uganda
Authors: Babirye Susan , Michielsen Kristien , Ssengooba Freddie
Published: December 2023

Introduction

There is increasing appreciation of the need to understand how social and structural factors shape HIV risk. The unwritten rules, also known as informal institutions or social norms, are increasingly recognized as important determinants of HIV transmission. Unfortunately, these informal institutions, especially among high-risk environments for HIV, such as social venues like bars, lodges, remain poorly understood. This study explored the informal institutions at social venues, and how these institutions influenced vulnerability for HIV for venue workers in Uganda.

Methods

We conducted a qualitative study in two districts of Kyotera and Rakai in Central Uganda. We purposively selected and interviewed 44 workers including, cleaners, waiters, and waitresses and 22 venue managers at 22 social venues to explore the informal institutions at these establishments and how the institutions shaped HIV vulnerabilities among the workers. 31.8% (14) of the participants were males, and 68.2% (30) females. Data were analyzed using thematic content analysis.

Results

We found that the informal institutions at the venues were both officially and socially created, communicated, and sanctioned. The most common institutions operated through; selective hiring, rigid reporting structures, and informal job contracting procedures. Meager salaries, varying and delayed payments as well as attractive benefits and bonuses from customers were also important forms of informal institutions at the venues. Drinking alcohol, and offering sexual services at the venues were acceptable, although excessive drinking, and committed sexual relationships with customers were disapproved. These informal institutions shaped a risk environment at the venues by creating risk exposure opportunities that influenced workers' engagement into sexual risk behaviors.

Conclusion

The risk environment at social venues is shaped by the informal institutions at these venues. Thus, the need for venue-based HIV programs that integrate social norms interventions to better address the contextual determinants of HIV risk behaviors at the venues.
The impact of COVID-19 on pulmonary, neurological, and cardiac outcomes: evidence from a Mendelian randomization study
Authors: Shenoy Pooja U. , Udupa Hrushikesh , KS Jyothika , Babu Sangeetha , K Nikshita , Jain Neha , Das Ranajit , Upadhyai Priyanka
Published: December 2023

Background

Long COVID is a clinical entity characterized by persistent health problems or development of new diseases, without an alternative diagnosis, following SARS-CoV-2 infection that affects a significant proportion of individuals globally. It can manifest with a wide range of symptoms due to dysfunction of multiple organ systems including but not limited to cardiovascular, hematologic, neurological, gastrointestinal, and renal organs, revealed by observational studies. However, a causal association between the genetic predisposition to COVID-19 and many post-infective abnormalities in long COVID remain unclear.

Methods

Here we employed Mendelian randomization (MR), a robust genetic epidemiological approach, to investigate the potential causal associations between genetic predisposition to COVID-19 and long COVID symptoms, namely pulmonary (pneumonia and airway infections including bronchitis, emphysema, asthma, and rhinitis), neurological (headache, depression, and Parkinson’s disease), cardiac (heart failure and chest pain) diseases, and chronic fatigue. Using two-sample MR, we leveraged genetic data from a large COVID-19 genome-wide association study and various disorder-specific datasets.

Results

This analysis revealed that a genetic predisposition to COVID-19 was significantly causally linked to an increased risk of developing pneumonia, airway infections, headache, and heart failure. It also showed a strong positive correlation with chronic fatigue, a frequently observed symptom in long COVID patients. However, our findings on Parkinson’s disease, depression, and chest pain were inconclusive.

Conclusion

Overall, these findings provide valuable insights into the genetic underpinnings of long COVID and its diverse range of symptoms. Understanding these causal associations may aid in better management and treatment of long COVID patients, thereby alleviating the substantial burden it poses on global health and socioeconomic systems.
Exploring the role of AI in classifying, analyzing, and generating case reports on assisted suicide cases: feasibility and ethical implications
Authors: Spitale Giovanni , Schneider Gerold , Germani Federico , Biller-Andorno Nikola
Published: December 2023

This paper presents a study on the use of AI models for the classification of case reports on assisted suicide procedures. The database of the five Dutch regional bioethics committees was scraped to collect the 72 case reports available in English. We trained several AI models for classification according to the categories defined by the Dutch Termination of Life on Request and Assisted Suicide (Review Procedures) Act. We also conducted a related project to fine-tune an OpenAI GPT-3.5-turbo large language model for generating new fictional but plausible cases. As AI is increasingly being used for judgement, it is possible to imagine an application in decision-making regarding assisted suicide. Here we explore two arising questions: feasibility and ethics, with the aim of contributing to a critical assessment of the potential role of AI in decision-making in highly sensitive areas.
Dam removal blind spots: debating the importance of community engagement in dam decommissioning projects
Authors: Matanzima Joshua , Mosuoe-Tsietsi Teboho
Published: December 2023

This article calls for social justice within the transition from dam building to decommissioning. Dam decommissioning is escalating in the global north, and sooner than later, the tied will spread to the global south. Though dam removal is an essential strategy for riverine landscape restoration, it may yield negative social outcomes for communities living along dams. Ecological restoration must not be achieved at the expense of local communities. Decisions on dam removal are predominantly made by experts and government agencies, often to the exclusion of local communities. For this reason, the decisions to remove several dams in the global north have been opposed by local communities leading to suspension or, in worst-case scenarios, reversal of such decisions. By referring to cases from Europe, USA, and Canada where dam removals have been opposed, this article argues for better incorporation of local communities in decision-making. Community consultations and consent are key in achieving successful decommissioning with minimal harm on communities. Yet, they have not received sufficient attention in dam removal conversations. The socio-economic issues are also not sufficiently interrogated in the literature on dam removal. We underscore this gap and provides recommendations for best social performance in dam removals.
“if we don’t regroup, hunger will kill us…”: a qualitative study on measures of physical distancing during covid-19 among internally displaced persons in Burkina Faso
Authors: Kadio Kadidiatou , Ly Antarou , Ouédraogo Adidjata , Ahmed Mohamed Ali Ag , Yaya Sanni , Gagnon Marie-Pierre
Published: December 2023

This study contributes to the body of knowledge on IDPs in the context of security crisis related to terrorism. Very little research has been done on covid-19 amongst IDPs in Africa and this is one of the first studies in Burkina Faso. Our diversified sample allowed us to consider the discourses of humanitarian actors working with IDPs, but also the discourses of IDPs in a context of aggravated health and security crisis. The challenges encountered by IDPs in implementing physical distancing and the coping strategies have been documented. It showed some possible solutions that decision-makers could use in order to facilitate the appropriation of this measure by IDPs. This is a contribution to the field of applied human and social science research They will help to anticipate solutions in the event of a resurgence of covid-19 cases. In the current context, where the spread of the disease seems to be under control, concerted action should now be taken in the event of the detection of a case of covid-19 in the various IDP sites.
Monitoring load, wellness, and psychological variables in female and male youth national team football players during international and domestic playing periods
Authors: Andersen Thomas Rostgaard , Kästner Bennet , Arvig Mathias , Larsen Carsten Hvid , Madsen Esben Elholm
Published: December 2023

Aim

To study differences in total load exposure, wellness, and psychological variables in youth female (N = 19) and male (N = 20) national team football players during domestic and international playing periods, respectively.

Procedures

The players filled out questionnaires on well-being, stress, and resilience before and after both playing periods lasting 8 days each. The Hooper index was used to monitor daily wellness levels during both playing periods. The number of training sessions and matches were recorded, and the session rating of perceived exertion was collected. Training load, monotony, and strain were calculated. Daily measurements were used to evaluate in-period changes, and composite scores were used to describe differences between periods.

Results

The international compared to the domestic playing period was for both groups characterized by more matches played, longer field training session durations, and of fewer gym-based sessions (P < 0.05). The male players increased total exposure time (25%; P < 0.05), monotony (P < 0.001), and strain (P < 0.001), which was not changed in the female players. Well-being decreased (P < 0.05) during the international playing period in male players. Stress levels were higher (P < 0.05) for both genders during the international compared to the domestic playing period. During the international playing period, positive correlations were found between the initial levels of stress, and the change in stress (P = 0.03; r2 = 0.12), and between the changes in total load and changes in well-being (P = 0.02; r2 = 0.12), whereas a negative correlation was found between the changes in wellness and stress (P = 0.03; r2 = 0.14).

Conclusion

A playing period characterized by increased match focus, longer field training sessions, and fewer gym-based training activities may lead to changes in the physical and mental profiles of youth national team football players. Alterations to load exposure and wellness may influence mental health. Players with high initial stress levels may be subjected to greater changes compared to other players. Sports scientists and medical staff may benefit from initiating structured monitoring systems to track alterations in physical load and mental health in youth national team players.