bluuebunny/crossref_metadata_2025 huggingface dataset:
Real Time Traffic Sign Recognition Using Integrated Camera Sensors and YOLOV8 Algorithm
Authors: Alfiana Ramadhani  , Yusuf Athallah Adriyansyah
Published: August 2024

Traffic signs are an important element in maintaining smoothness and safety on the road. However, there are still many drivers who violate them, causing various negative impacts. Traffic Sign Recognition (TSR) is a technology that has the ability to detect and identify various types of traffic signs by utilizing artificial intelligence in the computer vision domain. TSR has been applied in various vehicle applications, such as Advance Driver Assistance System (ADAS) and Autonomous Driving System (ADS). This system is made by integrating camera sensors with the YOLOv8 algorithm which has high accuracy and fast data processing. The data used were 2093 images and annotated through Roboflow. Then the data is trained through Google Collaboratory with a mAP evaluation result of 95.5% which shows that the system can detect objects accurately. The level of precision and success of the model in detecting objects is 93.5% and the success is 93.3%. The results of system testing can use images, videos, and through cameras in real time.
Investigating Students’ Difficulties in Translating English Academic Texts into Indonesian Using Photovoice
Authors: Praptika Diana , Rokhuma Chubbi Millatina
Published: August 2024

Translation is the process of transferring the meaning of a text from the source language (SL) to the target language (TL). However, many students experience difficulties in the translation process. This study aimed to reveal the difficulties faced by students in translating English academic texts especially English journal articles into Indonesian and the strategies they use to overcome their difficulties. It investigated students' experiences using qualitative approach with photovoice as the research design. The data collection was carried out by using photographs as well as semi-structured interviews. The gathered data were then analyzed by following steps of thematic analysis. This type of analysis helped the researcher identify students' difficulties and the translation strategies they use through their photos and descriptions. The results showed that the students have difficulties in pragmatics, cultural, and textual. In solving these difficulties, the students used some strategies including transference, naturalization, cultural equivalent, descriptive equivalent, synonymy, through translation, shift or transposition, reduction, paraphrase, couplets, and addition. The result of this research can be used by educators as a reference to identify the difficulties faced by their students early in translating academic texts. Therefore, they can guide their students to find the right strategies by using different types of difficulties.
Length-weight Relationship, Condition Factor and DNA Barcoding of Bonylip Barb, Osteochilus vittatus (Valenciennes, 1842) in Dampelas Lake, Central Sulawesi, Indonesia
Authors: Serdiati Novalina , Ndobe Samliok , Rosyida Eka , Gani Abdul , Hermawan Roni , Nurdin Muh. Saleh , Sari Devi Elvina , Herlina Sri , Pawaro Moh. Fadlan Daeng , Danty Astri Rahma
Published: August 2024

Dampelas Lake, also known as Talaga Lake, in Central Sulawesi Indonesia, lacks data on fish communities, especially biological aspects, including a wild population of bonylip barb Osteochilus vittatus (Valenciennes, 1842). Locally known as ikan nilem, this freshwater fish commodity is not native to Sulawesi. The purpose of this research was to analyze the length-weight relationship, condition factor and DNA barcode of the bonylip barb population in Dampelas Lake. Bonylip barb specimens (101 males and 78 females) were collected from Lake Dampelas during July 2023 using fish traps. The total length and weight ranges were 57-211 mm and 3-107 g. Length-weight relationships were W = 3×10-5 L2,8219 (males); W = 3×10-6 L3,2574 (females); and W = 1,1×10-5 L3,0176 (both sexes combined), indicating an isometric growth pattern. Condition factor ranged from 0.471-1.652 with similar mean values for males (1.01) and females (1.02). DNA barcodes for Lake Dampelas bonylip barbs nested in one of four O. vittatus clades, indicating a need for reviewing Osteochilus taxonomy. Most adult females had spent gonads, indicating seasonal spawning, with implications for developing an economically viable fishery which could also help control this non-native species in Dampelas Lake.Keywords: Cyprinidae, freshwater fisheries, growth pattern, introduced fish, mitochondrial DNA
Wound-healing and polymorphisms in platelet 5-HTR2A receptors: a molecular approach
Authors: Piatto Vânia Belintani , Cagnim Nuevo Luana Vilches , Barros Duarte Alexandre Alberto , Teixeira Ferdinando Danielle Lopes , Lúcio Flávia Daniele
Published: August 2024

Wound healing involves a well-orchestrated sequence of complex and dynamic events that occur in different phases: hemostasis, inflammation, proliferation, contraction, and remodeling. Each phase is characterized by specific cellular and molecular events that contribute to the repair of damaged tissues and can be influenced by several factors, including genetics. The serotonin receptor gene 5-hydroxytryptamine receptor-2A (5-HTR2A), encodes 5-HTR2A receptors which are a type of serotonin receptor. These receptors, which secrete serotonin during platelet activation, play an important role in wound healing, particularly in the phases of hemostasis, inflammation, proliferation, and angiogenesis, facilitating efficient and adequate tissue repair. Genetic changes or polymorphisms, especially the 102T-C polymorphism, can significantly impact these tissue-healing processes in the 5-HTR2A gene, by influencing the expression of platelet 5-HTR2A receptors. This review highlights the need for a new look to broaden the horizons of molecular understanding of tissue repair and wound healing.
Space Theory
Authors: Chen S.
Published: August 2024

The author introduces a novel theoretical framework that suggests matter and energy are both converted from curved space. In Space Theory, gravitation is generated by the flow of space, instead of being transmitted by the graviton as in String Theory. This theory also suggests that Newton's gravitational constant, denoted as G, may not be truly constant but could vary over time. The equivalent equation of space is S=Ec2=mc4, and the gravitation of hollow sphere space is Sμν=4πGm=(4/3)π((r+a)3-r3). The Space Theory also predicts that the surface gravitational acceleration of the neutron star Crab Pulsar (PSR B0531+21) is approximately 8.21924883×106 m/s2.
An Efficient Gaussian Mixture Model and Its Application to Neural Network
Authors: Lu Weiguo , Ding Deng , Wu Fengyan , Yuan Gangnan
Published: August 2024

Gaussian mixture models (GMMs) are powerful tools specifically suited for problems where data distributions are multi-modal. Inspired by Fourier expansion, we propose a concept called GMM expansion to approximate arbitrary densities. A simple learning method is introduced under this framework. Theoretical and numerical analyses are provided to show that densities under GMM expansion are able to approximate arbitrary densities with certain accuracy. The proposed learning algorithm demonstrates better accuracy and time efficiency compared to classic density approximation methods such as the Expectation Maximization (EM) algorithm and Bayesian variational inference (BVI) for Gaussian mixture models. The proposed framework also shows better accommodation of neural networks. Three neural network applications are built to demonstrate its usability. The accuracy of density estimation in neural networks is reported to be significantly improved in one of the applications. Another application shows that latent variables can be easily turned into random variables. This user-friendly method opens up more possibilities in terms of latent manipulation, embedding techniques, and many other potential uses.
Targeting Clonal Mutations with Synthetic Microbes
Authors: Renteln Michael
Published: August 2024

Recently concluded, large-scale cancer genomics studies involving multiregion sequencing of primary tumors and paired metastases appear to indicate that many or most cancer patients have one or more “clonal" mutations in their tumors. Clonal mutations are those that are present in all of a patient’s cancer cells. Clonally mutated proteins can potentially be targeted by inhibitors or E3 ligase small molecule glues, but developing new small molecule drugs for each patient is not feasible currently. Achilles Therapeutics is currently the only company specifically targeting clonal mutations. However, they are doing so with tumor-derived T cells. To address the potential limitations of immunotherapy, I have devised another approach for exploiting clonal mutations, which I call “Oncolytic Vector Efficient Replication Contingent on Omnipresent Mutation Engagement” (OVERCOME). The ideal version of OVERCOME would likely employ a bioengineered facultative intracellular bacterium. The bacterium would initially be attenuated, but (transiently) reverse its attenuation upon clonal mutation detection.
Genomic Exploration of Pediatric Neurological Diversity: Lessons from Clinical Exome Panel Sequencing
Authors: Tayade Naresh , A Anjali Krishna , Manoj Gautham , Kewat Akshay , Devulapalli Rajiv , Kumar Somesh , Polipalli Sunil K , Nair Bipin G , Bandapalli Obul Reddy , Suravajhala Prashanth
Published: August 2024

Background: Pediatric neurological disorders include neurodegenerative disease causing cognitive impairment, vision loss to mention a few. They are one of the important causes of morbidity and mortality in children with diverse etiology. Diagnosis is difficult in spite of genetic work and in only 60% of cases final diagnosis can be achieved. Case presentation: We explore three cases of pediatric neurological diseases, viz. Arthrogryposis, congenital bilateral cataract and Autism by analyzing clinical exomes. In this work, we attempted to understand rare neurological disorders in an Indian pediatric cohort using exome studies. Conclusions: We used our benchmarked CONVEX pipeline for screening consensus variants, wherein EIF2B2 was found to be inherently pathogenic. We map the association of variants and genes, disease correlation to neuroleptic malignant syndrome which is a matching phenotype to the cases.
Exploring Corporate Tax Avoidance: Effects on Comprehensive Budget Income – a Practical Analysis
Authors: Abu Huson Yazan , Alqudah Mohammad , Aljawarneh Nader Mohammad , Obeidat Abdallah Mishael
Published: August 2024

This paper addresses the pressing concern of corporate tax evasion recognized by several nations, employing insights from public choice theory and tax compliance theory. The research aims to evaluate the ramifications of corporate tax evasion on public revenue, public expenditures, tax rates, and the prevailing budget deficit. Methodologically, the study utilizes questionnaire data and employs structural equation modeling for analysis. The findings indicate that tax evasion is significantly influenced by multiple factors, encompassing tax income, public expenditures, tax rates, and the budget deficit. The article offers a comprehensive exploration of both theoretical frameworks and practical implications, contributing valuable insights to the ongoing discourse on corporate tax evasion and its multifaceted impact on fiscal dynamics.
Calculation of Low-Lying Electronic Excitations of Magnesium Monofluoride: How Well Do Coupled-Cluster Methods Work?
Authors: Horbatsch Marko
Published: August 2024

Magnesium monofluoride is a polar molecule amenable to laser cooling which has caused renewed interest in its spectroscopy. In this work we consider the case of three low-lying electronic excitations, namely $\rm X \, {}^{2}\Sigma \to A \, {}^{2}\Pi, \ \to B \, {}^{2}\Sigma, \ \to C \,{}^{2}\Sigma$, using well developed quantum chemistry approaches, i.e., without reference to the spin-orbit splitting of the $\rm A \, {}^{2}\Pi$ states. Accurate experimental data for these transitions have been available for over 50 years. Here we explore the linear response method at the level of CC2 theory, as well as equation of motion methods at the level of CCSD and CC3, using two families of basis sets. Excellent agreement is obtained for the first three transitions when using the correlation-consistent basis sets and extrapolation to the complete basis limit within EOM-CC3 (at a relative precision of $10^{-4}$), and qualitative agreement for the other two methods. The purpose of this paper is to serve as a guide in how to approach the accurate calculation of excitations in polar diatomic molecules.
Chanting of Nam-Myoho-Renge-Kyo in the Context of the Buddhist Liturgy of Nichiren Shoshu: Study of Sound Frequencies, Brain Activity, and Microbial Metabolism
Authors: Ruggiero Marco
Published: August 2024

This study investigates the effects of chanting Nam-Myoho-Renge-Kyo by a long-term Nichiren Shoshu Buddhist practitioner on sound frequencies (A), brain activity (B), and microbial metabolism(C).A. Analysis of sound frequencies: Spectral analysis of chanting revealed peaks at 8 Hz and 116 Hz, corresponding to the first Schumann resonance and a frequency linked to chloride ion movements, respectively. Additionally, five peaks (417, 528, 639, 741, 852 Hz) corresponding to solfeggio frequencies were identified. These frequencies are known to exert a positive impact on the human endocrine and autonomous nervous systems; improve survival of human brain cells; decrease anxiety in rats; reverse cognitive and endocrine deficits in zebra fish; reduce total concentration of reactive oxidative species in brain tissue. B. Study of Brain activity: Brain activity changes were measured using functional near-infrared spectroscopy. Prefrontal cortex activity increased modestly during chanting compared to a pre-chanting baseline, but significantly increased afterwards. This suggests a shift towards focused attention during chanting and enhanced activity afterward. C. Effects on microbial metabolism: Probiotic cultures exposed to chanting, either directly or indirectly, showed increased metabolic activity. This suggests local and non-local effects, similar to previously reported phenomena. Importantly, this study clarifies that the spiritual practice of Nichiren Shoshu Buddhism transcends mere neurophysiological explanations. While brain activity and other bodily processes may be correlated with the practice, the religious and spiritual experience of chanting Nam-Myoho-Renge-Kyoencompasses a mystical dimension that, though not contradicting science, cannot be fully explained by scientific methods alone.
Changes in Soil Organic Matter Associated with Land Use of Arenosols from Southern Botswana
Authors: Kgathi Donald , Sekhwela Mogodisheng , Almendros Gonzalo
Published: August 2024

The effect of land use on sandy soils of southern Botswana was carried out by comparing the composition and properties of soil organic matter. Virgin and disturbed soils were sampled from savanna ecosystems (Central District and Kweneng District). The biodegradability of organic matter was evaluated by incubation in the laboratory. Humic fractions were quantified and humic acids were analyzed by visible and infrared spectroscopy. The results indicate that continued disturbance, whether due to grazing or subsistence farming, has resulted in small significant changes in the concentration of available nutrients and organic matter in the soil. Nevertheless, substantial changes could be established in soil C/N ratio, humic acid/fulvic acid ratio and in the biodegradability of soil organic matter and the structural characteristics of humic acids. The increased aromaticity of humic acid (visible and IR spectroscopies) following disturbance, suggests increased biogeochemical activity and/or the impact of abiotic processes (such as periodic fires) selectively removing aliphatic constituents. The overall results indicate a low potential soil fertility, the sustainable preservation of which depending more on features related to quality than to the total amount of the soil organic matter, which shows considerable aromatization parallel to its degree of association with the mineral fraction.
Energy-Optimized 3D Path Planning for Unmanned Aerial Vehicle
Authors: Nagy István , Laufer Edit
Published: August 2024

Drone technology has undoubtedly become an integral part of our everyday life these days. The business and industrial use of unmanned aerial vehicles (UAV) can provide advantageous solutions in many areas of life, and they are also optimal for emergency situations and for accessing hard-to-reach places. However, their application poses numerous technological and regulatory challenges to be overcome. One of the weak links in the operation of UAVs is the limited availability of energy. In order to address this issue authors developed a novel trajectory planning method for UAVs to optimize the energy necessity during flight. First, an “energy map” was created, which was the basis for trajectory planning, i.e., determining the energy consumption of the individual components. This was followed by configuring the 3D environment including partitioning of the work space (WS), in fact, defining the free spaces, occupied spaces (obstacles) and semi-occupied/free spaces. Then the corresponding graph-like path(s) were generated on the basis of the partitioned space, where a graph search-based heuristic trajectory planning was initiated, taking into account the most important wind conditions including velocity and direction. Finally, in order to test the theoretical results, some sample environments were created to test and analyse the proposed path generations. The method eventually proposed was able to determine the optimal path in terms of energy consumption.
Integrated Method of Deep learning and Large Language Model in Speech Recognition
Authors: Guan Bo , Cao Jin , Wang Xingqi , Wang Zhuoyue , Sui Mingxiu , Wang Zixiang
Published: August 2024

This research aims to explore the integration method of deep learning and large language models in speech recognition to improve the system’s recognition accuracy and ability to handle complex contexts. Deep neural network (DNN), convolutional neural network (CNN), long short-term memory network (LSTM) and Transformer-based large language model are used to build an integrated acoustic and language model framework. Experiments on TIMIT, LibriSpeech and Common Voice datasets show that the ensemble model shows significant improvements in both word error rate (WER) and real-time factor (RTF) compared to traditional models. Especially in terms of adaptability to multiple languages and accent changes, the model shows superior performance. The conclusion shows that through technology integration, the performance of the speech recognition system in complex environments can be effectively improved, providing a new direction for the future development of speech recognition technology.
Personal Resources for Psychological Well-Being in University Students: The Role of Psychological Capital and Coping Strategies
Authors: Moreno Esteban , Ferradás María del Mar , Freire Carlos
Published: August 2024

In recent years, research has noted the increasing prevalence of mental health problems among university students. The current mental health needs of the university population, along with the multitude of stressors they face, increase the importance of examining their psychological well-being and determining the personal resources that effectively promote it. In this context, the present research aims to analyze the role of psychological capital (PsyCap) and coping strategies as personal resources facilitating psychological well-being (PWB) of university students. Specifically, the mediating role of coping strategies (both adaptive and maladaptive) in the relationship between PsyCap and PWB is explored. The study involved 391 university students from Spain. The results found a partial mediation effect of adaptive coping strategies on the relationship between PsyCap and PWB. Likewise, PsyCap was shown to be a direct positive predictor of adaptive coping strategies and PWB, as well as a direct negative predictor of maladaptive coping strategies. Therefore, it is concluded that PsyCap serves as a valuable personal resource that enhances and strengthens PWB in university students, as well as adaptive coping strategies. PsyCap also decreases the tendency to engage in maladaptive coping strategies. Similarly, the use of adaptive coping strategies contributes to improving students' PWB.
How Quickly Does the Impact of Forest Fires Reflect on the Quality of the Wood in Standing Trees?
Authors: Mușat Elena Camelia
Published: August 2024

Wood quality has been an ongoing concern for specialists, which has become increasingly important in the current context, where the demand for wood is increasing and forest fires are more frequent and violent. The article aims to evaluate the quality of wood in trees affected by fires and the negative impact of these phenomena on the speed of wood degradation, as a result of the weakening of the trees due to the action of disturbing factors. Investigations were carried out using modern techniques on the beech trees (Fagus sylvatica L.) remaining in an area affected by a litter fire in 2017. Measurements were taken were made with the Arbotom Rinntech sound tomograph, the IML F-500 Resi resistograph and the Pressler core sampler to observe the quality of the wood inside the trunk. It was found that all the trees are in various stages of decaying the tomograms being able to highlight the severity of the defects only in the case of the total destruction of the wood structure as a result of the action of xylophages fungi, whose harmful influence is more pronounced when the injuries sustained by the trees from the fire were greater. Although the trees tried to close the fire wounds through their own defense mechanisms, the destructive action of the fungi intensified with the time.After the forest fires, for quickly and clear results regarding the internal quality of the wood could be used the resistograph. For valuable trees could be used the tomograph, but the measurements have to be taken only by qualified operators.
Noncytotoxic Graphene Nanoplatelets Upregulates Cell Proliferation and Self-Renewal Genes of Mesenchymal Stem Cells
Authors: Nicoletti Natalia Fontana , Marinowic Daniel Rodrigo , Perondi Daniele , Budelon Gonçalves João Ismael , Piazza Diego , da Costa Jaderson Costa , Falavigna Asdrubal
Published: August 2024

Graphene nanoplatelets (UGZ-1004) are advancing as a promising biomaterial for regenerative medicine. This study provides a detailed assessment of UGZ-1004, emphasizing its physical properties, cytotoxicity, intracellular interactions, and particularly its effects on mesenchymal stem cells (MSCs). UGZ-1004 was characterized to have lateral sizes and layer counts in line with ISO standards and exhibited high carbon purity (0.08%). Cytotoxicity evaluations demonstrated that UGZ-1004 is non-toxic to various cell lines, including fibroblast 3T3, epithelial kidney VERO, microglia BV-2, and MSCs, in accordance with ISO-10993-5/2020/2023 guidelines. The study focused on MSCs, revealing that UGZ-1004 supports their self-renewal and proliferation. MSCs exposed to UGZ-1004 maintained their characteristic surface markers and proliferation rates. Importantly, UGZ-1004 promoted significant upregulation of genes crucial for cell cycle regulation and DNA repair, such as CDK1, CDK2, and MDM2. This gene expression profile suggests that UGZ-1004 enhances MSC self-renewal capabilities, ensuring robust cellular function and longevity. Moreover, UGZ-1004 exposure led to the downregulation of genes associated with tumor development, including CCND1 and TFDP1, mitigating potential tumorigenic risks. These findings underscore the potential of UGZ-1004 to not only bolster MSC proliferation but also enhance their self-renewal processes, which are critical for effective regenerative therapies. The study highlights the need for continued research into the long-term impacts of graphene nanoplatelets and their application in MSC-based regenerative medicine.
Review of Strategies and Policies for Enhanced Participation in Global Value Chains
Authors: Dutta Sourish
Published: August 2024

This article underscores the immense potential for substantial economic growth and development that can be harnessed through effective participation in global value chains (GVCs). It emphasises the role of policymakers in adeptly navigating GVCs, prioritising tasks, exploring different forms of GVC governance, and fostering a conducive environment for foreign investments. By effectively managing power dynamics and supply chain risks, countries can attract valuable foreign investors, enhance market connectivity, and improve infrastructure and services, leading to significant economic growth. The potential benefits of GVC participation are vast, and policymakers can shape the situation by understanding and addressing strategic inquiries, laying the foundation for a prosperous future. Furthermore, the article explores the potential for a country to enhance its involvement in GVCs and progress to more lucrative activities by strengthening existing connections between GVCs and the local economy. By enhancing the capacity of local stakeholders to acquire knowledge, policymakers can play a crucial role in maximising the benefits from GVC spillovers, positively impacting a country's economic development.
Enhancing Greenhouse Efficiency: Integrating IoT and Reinforcement Learning for Optimised Climate Control
Authors: Platero-Horcajadas Manuel , Pardo-Pina Sofia , Cámara-Zapata José-María , Brenes Jose A , Ferrández-Pastor Francisco-Javier
Published: August 2024

Automated systems, regulated by algorithmic protocols and predefined set-points for feedback control, require the oversight and fine-tuning of skilled technicians. This necessity is particularly pronounced in automated greenhouses, where optimal environmental conditions depend on the specialized knowledge of dedicated technicians, emphasizing the need for expert involvement during installation and maintenance. To address these challenges, this study proposes the integration of data acquisition technologies using Internet of Things (IoT) protocols and optimization services via Reinforcement Learning (RL) methodologies. The proposed model was tested in an industrial production greenhouse for the cultivation of industrial hemp, applying adapted strategies to the crop, and was guided by an agronomic technician knowledgeable about the plant. The expertise of this technician was crucial in transferring the RL model to a real-world automated greenhouse equipped with IoT technology. The study concludes that the integration of IoT and RL technologies is effective, validating the model's ability to manage and optimize greenhouse operations efficiently and adapt to different types of crops. Moreover, this integration not only enhances operational efficiency but also reduces the need for constant human intervention, thereby minimizing labor costs and increasing scalability for larger agricultural enterprises. Furthermore, the RL-based control has demonstrated its ability to maintain selected temperatures and achieve energy savings compared to classical control methods.
Review On Construction Firms Performance Assessment Methods, Using Qualitative Content Analysis
Authors: Naderi Amirnojan , Golroo Amir , Hajarolasvadi Hossein
Published: August 2024

A corporate head office for large construction firms, holds more of a staffing role and facilitates, controls and manages subsidiaries. According to studies, little awareness of how to manage affairs, the unfavorable business environment, the lack of necessary rules and the structure of capital, form the most critical management areas to be thoughtful of. In dynamic systems, complex subject, refers to a problem in which the number of factors and relations in between are very high and sometimes unknown. In managing large construction firms, a similar situation prevails. Controlling and evaluating organization and management based on the correct information is something that is difficult to accomplish. This research seeks to provide a comprehensive review on construction firms performance measurements methods by using qualitative methods and necessary software tools. For this purpose, a summary is made of studies on areas such as construction companies, performance assessment solutions and content analysis methods. Then, considering the research gap, the research methodology will be developed, which will provide the optimal result for gathering different assessment methods suitable for construction firms in study. This article offers a step-by-step description of how qualitative data analysis software can be used for quantifying data and decision making. As illustrated in this research, using Nvivo shows how software tools can facilitate analytical flexibility and how they can enhance effectiveness of the qualitative research process. The article, aside from proposing the optimum performance assessment method for companies in study, concludes that while qualitative data analysis software will not do the analysis for the researcher, it can make the analytical process more flexible, transparent and ultimately more trustworthy.
GeoQuickView: Simplifying LiDAR-Derived Raster Visualization for Everyone
Authors: Hegyi Alexandru
Published: August 2024

GeoQuickView is a software application designed to bridge the gap between advanced Geographic Information Systems (GIS) and users with no prior experience in GIS. This paper explores the development, functionality, and user-centric design of GeoQuickView, highlighting its capabilities in loading, visualizing, and analyzing geographic data. Emphasis is placed on its use with LiDAR-derived Digital Terrain Models (DTMs), user-friendly interface, and robust tools for measurement and digitization. The application’s role in democratizing access to complex geospatial data is discussed. The software was designed to work seamlessly with data from Romania and can display various types of raster elevation data. While the Coordinate Reference System (CRS) may present challenges for data extraction outside of Romania, the data can still be visualized effectively within the app. The application is available upon request.
Application of Attribute-Based Encryption in Military Internet of Things Environment
Authors: Pióro Łukasz , Sychowiec Jakub , Kanciak Krzysztof , Zieliński Zbigniew
Published: August 2024

Military Internet of Things (MIoT) has emerged as a new research area in military intelligence. The MIoT frequently has to constitute a federation-capable IoT environment when the military needs to interact with other institutions and organizations or carry out joint missions as part of a coalition such as in NATO. One of the main challenges of deploying MIoT in such an environment is to acquire, analyze, and merge huge amounts of data from many different IoT devices and disseminate it in a secure, reliable, and context-dependent manner. In this work, we present a comprehensive solution for secure data dissemination based on the integration of Hyperledger Fabric's distributed registry technology, Apache Kafka message broker, and data processing microservices implemented using the Kafka Streams API library and applying attribute-based encryption (ABE), a cryptographic approach that facilitates controlling access to information based on data and user attributes rather than traditional methods that rely on specific keys. In the work, we built an experimental setup, implemented an access control scheme designed for mobile components, and performed an evaluation of its performance. Performance tests have confirmed the suitability of the developed cryptographic method for attribute-based data access control in MIoT systems, considering the federations of military networks. The results indicate that the proposed cryptographic scheme is viable for the number of attributes typically assumed to be used in battlefield networks, offering a good trade-off between security and performance for modern cryptographic applications.
Magnetic Nanoparticles with On-Site Azide and Alkyne Functionalized Polymer Coating in a Single Step through a Solvothermal Process
Authors: MORA-CABELLO ROMUALDO , FUENTES-RIOS DAVID , GAGO LIDIA , CABEZA LAURA , Moscoso Ana , Melguizo Consolacion , Prados Jose , Sarabia Francisco , LOPEZ-ROMERO JUAN MANUEL
Published: August 2024

Magnetic Fe3O4 nanoparticles (MNPs) are becoming more important every day in drug targeting. We prepared here MNPs in a simple one-step reaction by following the solvothermal method assisted by azide and alkyne functionalized polyethylene glycol (PEG400) polymers, as well as by PEG6000 and the polyol -cyclodextrin (CD). The composition, morphology, and structure of the nanospheres were characterized using Transmission Electron Microscopy (TEM), Nuclear Magnetic Resonance (NMR), X-Ray Diffraction Diffractometry (XRD), Atomic Force Microscopy (AFM), Fourier-Transform Infrared Spectroscopy (FT-IR), Matrix-Assisted Laser Desorption/Ionization (MALDI) and Vibrating Sample Magnetometry (VSM). The obtained nanoparticles (@Fe3O4-PEGs and @Fe3O4-CD) showed diameters between 90-250 nm, depending on the polymer used and the Fe3O4·6H2O precursor concentration, typically, 0.13 M, 200 °C, and 24 h of reaction. MNPs exhibited superparamagnetic properties with high saturation of magnetization at room temperature, reaching values of 59.9 emu/g (@Fe3O4-PEG6000), and no ferromagnetism. Likewise, they showed temperature elevation after applying an alternating magnetic field (AMF) in all cases, obtaining Specific Absorption Rate (SAR) values of up to 51.87 ± 2.23 W/g in the case of @Fe3O4-PEG6000. Both PEGs and the βCD played a crucial role as electrostatic stabilizers in the formation of Fe3O4 nanospheres, providing a polymeric/polyol coating around the magnetic cores. Additionally, the formed systems are susceptible for click chemistry, as was demonstrated in the case of the cannabidiol-propargyl derivative (CBD-Pro), which was synthesized and covalently attached to the azide functionalized surface of the system @Fe3O4-PEG400-N3. Prepared MNPs are highly dispersible in water, remaining in suspension for over 3 days, and non-toxic in the T84 human colon cancer cell line, indicating that they are ideal candidates for biomedical applications.
Photoinduced Mechanisms of C-S Borylation of Methyl(p-Tolyl)sulfane with Bis(pinacolato)diboron: A Dft Investigation
Authors: Ming Yuxiao , Feng Tiantian , Chen Bin , Zhou Dagang
Published: August 2024

The reaction mechanisms of C-S borylation of aryl sulfides catalyzed by the 1,4-benzoquinone (BQ), were investigated by employing M06-2X-D3/ma-def2SVP method and basis set. In this study, the SMD model was taken to simulate the solvent effect of 1,4-dioxane. Also, TD-DFT calculations of BQ and methyl(p-tolyl)sulfane were performed in SMD solvent model. The computational results indicated that BQ and methyl(p-tolyl)sulfane, serving as a photo-catalyst, would be excited under blue LED of 450 nm, aligning well with experimental observations. Additionally, the role of 3O2 was investigated, revealing that it could be activated to 1O2 from the released energy of 1[BQ+methyl(p-tolyl)sulfane]* or 3[BQ+ methyl(p-tolyl)sulfane]*→BQ+ methyl(p-tolyl)sulfane process. Then 1O2, bis(pinacolato)diboron, and methyl(p-tolyl)sulfane would through a series of reactions to yield the final product P. The Gibbs free energy surface show that path a2-2 is optimal and this path has less steps and lower energy barrier. The electron spin density isosurface graphs were employed to analyze structures and elucidate the single electron distribution. These computational results offer valuable insights into the studied interactions and related processes and shed light on the mechanisms governing C–S borylation from aryl sulfides and b2pin2 catalyzed by BQ and methyl(p-tolyl)sulfane.
Impact of the Implementation of a Selective Digestive Decontamination Protocol on Antibiotic Consumption in an Intensive Care Unit: A Quasi-Experimental Study
Authors: Martínez-Pérez María , Fernández-Fernández Rosario , Moron Rocio , Nieto-Sánchez María Teresa , Yuste Maria Eugenia , Díaz-Villamarín Xando , Fernández-Varón Emilio , Alberola-Romano Ana , Colmenero Manuel
Published: August 2024

The growing global threat of multidrug-resistant (MDR) bacteria has been exacerbated by inadequate antibiotic consumption and the difficulty in developing new therapeutic strategies. Selective Digestive Decontamination (SDD) is presented as an encouraging measure to prevent the appearance and colonization of MDR bacteria. We compared the pattern of antibiotic consumption in the Intensive Care Unit (ICU) of our hospital before and after the implementation of the SDD protocol. This quasi-experimental study was conducted in an ICU from June-2021 to June-2023. The incidence of nosocomial infections, colonizations, and the number of isolated MDR bacteria, as well as the defined-daily-dose (DDD), were monitored. A total of 3266 patients were included, with 1532 in the pre-intervention group and 1734 in the post-intervention group. The median age was 62 years, 66% were male, and the average APACHE II and SOFA scores were 15 and 6.5, respectively. There was a significant reduction in overall antibiotic consumption in the post-SDD group (p= 0.028), highlighting a decrease in Carbapenemase-Producing Enterobacteriaceae (CPE) (p= 0.0099). There was also a reduction in colonization incidence density and nosocomial infections. Implementing the SDD protocol significantly reduced antibiotic consumption in the ICU, suggesting important implications for infection control and antimicrobial resistance management.
Pharmacist Prescribed Hormonal Contraception: Perceptions of Georgia Community Pharmacists and Non-community Pharmacists in the Profession
Authors: Stone Rebecca H , Patel Megha D , Beene Lara
Published: August 2024

Pharmacist-prescribed hormonal contraception (HC) is supported by a majority of pharmacists and pharmacy students; however, few studies have evaluated perceptions of non-community pharmacists, or differences in geographic areas. The primary objective of this study is assess differences between community and non-community pharmacists in perceptions of pharmacist HC prescribing. Secondary objectives include assessment of community pharmacist interest in prescribing HC, and differences in perceptions between pharmacists in metropolitan and nonmetropolitan areas. A survey was emailed in early 2022 to 2592 Georgia pharmacists, with Likert questions assessing interest, perceptions, comfort, and perceived barriers regarding pharmacist prescribed HC. Completed survey response rate was 11.8%. Regardless of practice site, a majority agreed pharmacists are well-trained to prescribe HC (Community 61.8% vs. Non-community 68.1%, p=0.25) and provision of HC services is within the pharmacist’s scope (Community 73.6% vs. Non-community 74.2%, p=0.90). Overall metropolitan and non-metropolitan community pharmacists' perceptions were similar, however more metropolitan pharmacists believed pharmacists are well trained to prescribe HC (66.7% vs 48.7%, p=0.049) and that it is within their scope of practice (78.1% vs. 61.5%, p=0.045). In summary, the majority of pharmacists, regardless of practice type, believe that pharmacists are prepared to prescribe HC and it is a part of pharmacist’s professional scope of practice.
Use of Eltrombopag to Improve Thrombocytopenia and Transfusion Requirement in Anti-CD19 Car-T Cell-Treated Patients
Authors: Mingot-Castellano Maria-Eva , Reguera-Ortega Juan Luis , Zafra Torres Denis , Hernani Rafael , Lopez-Godino Oriana , Guerreiro Manuel , Herrero Blanca , Lopez-Corral Lucia , Luna Alejandro , González-Pinedo Lesli , Chinea-Rodriguez Anabelle , Martin-lópez Ana Africa , Bailen Rebeca , Martinez-Cebrian Nuria , Balsalobre Pascual , Filaferro Silvia , Alonso-Saladrigues Anna , Barba Pere , Pérez-Martínez Antonio , Calbacho María , Perez Simon Jose Antonio , Sanchez-Pina Jose Maria
Published: August 2024

Background/Objectives Immune effector cell-associated hematotoxicity (ICAHT) is a frequent adverse event after chimeric antigen receptor (CAR)-T cell therapy. Grade ≥3 thrombocytopenia occurs in around one third of patients, many of whom become platelet transfusion-dependent. Without pharmacological support, platelet recovery may last for months. Eltrombopag is a thrombopoietin receptor agonist (TPO-RA) able to accelerate megakaryopoiesis, which has been used successfully in patients with bone marrow failure and immune thrombocytopenia (ITP.) Its role to manage thrombocytopenia, and other cytopenias, in CAR-T cell-treated patients has been scarcely addressed in the real-world setting. Our aim was to report the Feasibility of this approach and the outcome of patients included in the GETH-TC registry. Methods This is a retrospective, multicenter, observational study. Patients who developed platelet transfusion-dependence subsequently to CAR-T cell treatment were recruited in 10 Spanish hospitals and followed-up for at least 30 days after the first dose of eltrombopag was administered. Results Thirty-eight patients were enroled and followed-up for a median (interquartile range [IQR]) of 175 (99, 489) days since CAR-T cell infusion. At eltrombopag start, 18 patients had thrombocytopenia and another severe cytopenia, while 8 patients had severe pancytopenia. After 32 (14, 38) days on eltrombopag, 29 (76.3%) patients recovered platelet transfusion independence. The number of platelet units used correlated with the time needed to restore platelet counts to levels ³20x109/L (Rho = 0.639, p <0.001). Non-responders to eltrombopag required more platelet units (58 [29, 69] vs. 12 [6, 26] in responders, p = 0.002). Nineteen out of 23 (82.6%) patients recovered from severe neutropenia after 22 (11, 31) days on eltrombopag. Twenty-nine out of 35 (82.9%) patients recovered red blood cell (RBC) transfusion independence after 29 (17, 44) days. Seven patients recovered all cell lineages while on treatment. No thromboembolic events were reported. Only 2 transient toxicities (cholestasis, hyperbilirubinemia) were reported during eltrombopag treatment, none of which compelled permanent drug withdrawal. Conclusions Eltrombopag can be safely used to manage thrombocytopenia and accelerate transfusion independence in CAR-T cell-treated patients.
Antibiotic Release and Mechanical Performance of PMMA Bone Cement: Findings from In Vitro Studies
Authors: Karaglani Makrina , Molla Moustafa Reichan , Panagopoulou Maria , Chatzaki Ekaterini , Drosos Georgios
Published: August 2024

Using polymethylmethacrylate (PMMA) bone cement is widespread in orthopedic surgeries for implant fixation and as a carrier for antibiotic delivery to prevent and treat infections. This review comprehensively evaluates in vitro studies investigating the antibiotic elution profiles and mechanical properties of PMMA bone cement. We explore the kinetics of antibiotic release, factors influencing elution efficiency, and the impact of various antibiotics on the mechanical properties of PMMA composites. At the same time, we examine how the inclusion of antibiotics affects the mechanical integrity of PMMA, including parameters such as compressive strength, tensile strength, and fatigue resistance. Through a detailed analysis of these studies, this review aims to provide insights into optimizing PMMA bone cement formulations for enhanced therapeutic efficacy and structural performance.
Bridge Deck Durability: Advanced Materials for Crack Mitigation
Authors: Jude Gabriel
Published: August 2024

The durability of bridge decks is a critical factor in ensuring the safety and longevity of transportation infrastructure. This article explores advanced materials and innovative techniques designed to mitigate cracking in bridge decks, a common issue that can compromise structural integrity and increase maintenance costs. It provides a comprehensive review of cutting-edge solutions such as Fiber-Reinforced Polymers (FRP), High-Performance Concrete (HPC), Ultra-High Performance Concrete (UHPC), and self-healing concrete technologies. Each material is analyzed for its ability to enhance strength, reduce permeability, and improve resistance to environmental stressors. Additionally, the article examines the role of surface treatments, sealants, and routine maintenance practices in prolonging the life of bridge decks. By synthesizing current research and practical applications, this article offers valuable insights and recommendations for engineers, contractors, and policymakers seeking to advance bridge deck durability through innovative materials and methodologies.
Vernonia amygdalina Leaf Extract Induces Apoptosis in HeLa Cells: A Metabolomics and Proteomics Study
Authors: Samutrtai Pawitrabhorn , Yingchutrakul Yodying , Faikhruea Kriangsak , Vilaivan Tirayut , Chaikeeratisak Vorrapon , Chatwichien Jaruwan , Krobthong Sucheewin , Aonbangkhen Chanat
Published: August 2024

Medicinal plants produce various bioactive molecules with potential anticancer properties with favorable safety profiles. We investigated the comprehensive composition of Vernonia amygdalina leaf extract and its cytotoxic effects via apoptosis in HeLa cells. The metabolomics approach was conducted to gather the metabolite profile of the extract. Proteomics was performed to understand the comprehensive mechanistic pathways of action. The apoptosis was visualized by cellular staining and the apoptotic proteins were evaluated. V. amygdalina leaf extract exhibited dose-dependent cytotoxic effects on both HeLa and Vero cells after 24 h of exposure, however, a higher concentration was required for Vero cells cytotoxicity. The metabolomic profile indicated that majority of metabolites were alkaloids, phenolic compounds, and steroids. The cytotoxic pathways involved the response to stress and cell death which was similar to doxorubicin. The upstream regulatory proteins, PTEN and XBP1, were significantly altered supporting the regulation of apoptosis and cell death. The levels of apoptotic proteins, JNK, p53, and caspase-9 were significantly increased. These provided strong evidence that V. amygdalina leaf extract related to the induction of apoptosis and highlighted its potential for the development of chemotherapy.
Advancements in Artificial Intelligence for Fetal Neurosonography: A Comprehensive Review
Authors: Weichert Jan , Scharf Jann Lennard
Published: August 2024

Detailed sonographic assessment of the fetal neuroanatomy plays a crucial role in prenatal diagnosis, providing valuable insights into timely well-coordinated fetal brain development and detecting even subtle anomalies that may impact neurodevelopmental outcomes. With recent advancements in artificial intelligence (AI) in general and medical imaging in particular, there has been growing interest in leveraging AI techniques to enhance the accuracy, efficiency, and clinical utility of fetal neurosonography. The paramount objective of this scoping review is to discuss the latest developments in AI applications in this field, focusing on image analysis, automation of measurements, prediction models for neurodevelopmental outcomes, visualization techniques, and integration into clinical routine.