bluuebunny/crossref_metadata_2025 huggingface dataset:
TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo
Authors: Wang Kun , Yao Dengbo , Li Yuxi , Li Ming , Zeng Weike , Liao Zhuangyao , Chen Engming , Lu Shixin , Su Kaihui , Che Zhen , Liang Yuwei , Wang Peng , Huang Lin
Published: September 2022

Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs). This study focused on the role and mechanism of the p38 inhibitor TAK-715 in intervertebral disc degeneration. Methods NPCs were treated with IL-1β to mimic apoptosis, followed by the addition of TAK-715. It was determined that apoptosis, inflammatory mediators (COX-2), inflammatory cytokines (HMGB1), and ECM components (collagen II, MMP9, ADAMTS5, and MMP3) existed in NPCs. In addition, the p38MAPK signaling pathways were examined. The role of TAK-715 in vivo was determined by acupuncture-induced intervertebral disc degeneration. Following an intraperitoneal injection of TAK-715, MRI and a histopathological analysis were conducted to assess the degree of degeneration. IL-1β-induced apoptosis was alleviated by TAK-715 in vitro, and antiapoptotic proteins were upregulated. Furthermore, TAK-715 blocked Results IL-1β-induced inflammatory mediator production (COX-2) and inflammatory cytokine production (HMGB1) and degraded the ECM (collagen II, MMP9, ADAMTS5, and MMP3). By inhibiting the phosphorylation of p38, TAK-715 exerted its effects. In a rat tail model, TAK-715 ameliorates puncture-induced disc degeneration based on MRI and histopathology evaluations. Conclusion TAK-715 attenuated intervertebral disc degeneration in vitro and in vivo, suggesting that it might be an effective treatment for IDD.
Upper ureteral calculi complicated with severe hydronephrosis and renal medullary carcinoma in elderly Chinese woman: a case report
Authors: Yu Qiwei , Wu Yufan , Yao Linya , Zhang Xi , Wang Jun , Li Xiang , Zeng Xueming
Published: September 2022

Renal medullary carcinoma is a rare and aggressive malignancy that commonly occurs in young African men with sickle cell disease. we report a case of a 64-year-old female patient with left renal medullary carcinoma who was hospitalized for severe hydronephrosis due to upper ureteral calculi obstruction. A laparoscopic left nephrectomy was performed, and the tumor was pathologically diagnosed with renal medullary carcinoma. Postoperative pain was not significantly relieved and the patient developed retroperitoneal metastasis 1 month later and died after 3 months of follow-up. For elderly patients with long-term kidney stones and altered kidney morphology, renal tumors should be considered.
An in-depth analysis of the clinical outcome of ischemic stroke patients with atrial fibrillation
Authors: Fan Fenghua , Li Shuai , Lin Kaibin , Zhao YuWu , Li Yuehua , Huang Dong , Li Jingbo
Published: September 2022

Background
Atrial fibrillation (AF) increases the risk of ischemic stroke (IS) in the general population. We sought to obtain the association of in-hospital mortality, stroke severity, and other clinic parameters with AF in IS patients.
Methods
We retrospectively analyzed the patients with acute IS in our hospital. They were divided into 2 groups: the AF group and the non-AF group. All patients received cranial computed tomography or magnetic resonance imaging (MRI) within 2 weeks of the onset of clinical symptoms. All patients were evaluated for stroke severity using the National Institute of Health Stroke Scale (NIHSS) score. Multivariate logistic regression was used to determine whether AF was associated with stroke severity and in-hospital death. A propensity score-matched analysis was used to estimate differences in severity and infarct volume between the two groups.
Result
The study cohort included 586 patients (AF group: n = 190, 103 female, median age = 80 years; non-AF group: n = 396, 182 female, median age = 68 years). Compared with non-AF group, AF group had higher admission and discharge NIHSS scores (median, 11 vs 3, and 7 vs 2; both P < 0.0001), longer hospital stays (median, 11 vs 10 days; P = 0.001), higher in-hospital mortality rate (24.2% vs 4.8%, P < 0.0001), and higher hospitalization costs [19182.64(11368.45,40808.35) vs 13329.54(10850.33,18629.34), China Yuan (CNY); P < 0.0001]. Multivariate logistic regression analyses found that AF was an independent risk factor for severe stroke (NIHSS score, ≥ 16) and inpatient death. In the two groups after a propensity score matching, the AF group had greater infarct volume [25.8(7.9–83.8) vs 1.4 (0.7–9.5) ml; P < 0.0001].
Conclusions
AF was associated with higher inpatient mortality, greater infarction volume, worse neurological deficits, and higher hospital cost. AF should be considered an independent risk factor for worse clinical outcomes in the IS patient.
TI-LMD-based multi-path effect extraction for GNSS coordinate time series
Authors: Huang Yinghua , LIU Chang-rui , Xudong Zheng , CHEN Zhuang , LI Hao , TANG Hao-yao , ZHANG Xian-zhou
Published: September 2022

A modified LMD (TI-LMD) method is proposed for the problems of endpoint effects, sliding average step size taking and modal confounding in the multipath effect extraction of GNSS coordinate time series applied by the local mean decomposition (LMD) method. Three main improvements are included: For the LMD endpoint effect, a matching delayed endpoint effect method based on similar triangular waveforms (MEBSTW) is proposed to find the best matching waveform from within the signal to the endpoint for endpoint delay. To address the problem of taking the sliding average step size, a method of taking the sliding average step size based on the sample skewness of the adjacent extreme point spacing (MSDAEP) is proposed to reduce the number of smoothing iterations while ensuring the smoothing accuracy as much as possible in order to improve the computational efficiency. For the LMD modal mixing problem, a Complementary Ensemble Local Mean Decomposition method based on alignment entropy detection (MCELMD) is proposed to combine alignment entropy detection, CELMD and LMD to solve the modal mixing in the decomposition process. Finally, the method is applied to the extraction of multi-path effects in actual GNSS coordinate time series, and it is verified that the method can extract multi-path effects in GNSS coordinate time series more effectively than the traditional LMD method, which has important practical significance for GNSS coordinate time series processing
3D Soil Corrosivity signature and model of Delta State, Nigeria for corrosion control
Authors: Amadi Azubuike H. , Ajienka Joseph A. , Akaranta Onyewuchi , Ola Victor D. , Ekeoma Bernard C. , Ajayi Kehinde E.
Published: September 2022

The challenge of data availability for accurately assessing a location's level of corrosivity has lingered for so long and as such, researchers are constantly seeking factors with great influence that can assist in describing how corrosive a location will be toward buried oil and gas infrastructure. Alternative measures are required for making rapid and realistic investment decisions because accumulating these factors to make perfect sense is sometimes time-consuming and expensive. Using MATLAB mathematical computational analysis, this study capitalizes on this gap to build a 3D corrosivity signature and model for Delta state, Nigeria to aid in rapid and realistic investment decision-making. The soil pH and resistivity were identified as key variables that determine the extent of corrosion in this investigation. Vertical Electrical Soundings were utilized to collect soil resistivity data, which was then combined with the soil pH to create a 3D corrosivity signature and model with a 98% R-square factor. During the study, potential limitations were found, and recommendations were made.
Dependency on external power supply to operate large-scale heat pumps to decarbonize Cogeneration-based District Heating Networks.
Authors: Hurst Georg , Jentsch Andrej , Blesl Markus
Published: September 2022

The sector integration of large-scale heat pumps (LSHP) into existing district heating networks (DHN), most of which are operated by combined heat and power plants (CHP), is observed to grow rapidly over the past few years. Due to significant lower operational and initial costs, the predominant configuration in DHN is a CHP+LSHP combination, where the LSHP is operated by internal power supply, provided by the CHP-plant. In a dynamic simulation based on aggregated data over the course of one year, specific CO2-emissions are calculated according to the exergetic Carnot methodology, fulfilling the first and sec-ond law of thermodynamics. In order to determine and quantify the ecologic benefit of a generic sector integrated LSHP, the specific CO2-emissions of the heat of the most common CHP-plants are compared to a LSHP operated by internal (CHP+LSHP) and external power supply (electrical grid and volatile renew-able energy sources (RES)). The analysis shows, that a generic LSHP operated by internal power supply out of every examined CHP-plant, seasonally independent generates heat with higher specific CO2-emissions over the heat from the CHP-plant alone. In contrast, the heat provided by the LSHP operated with external electricity from RES, achieves 5 to 16-fold lower CO2-emissions showing, that with growing share of power from RES in the electric grid, regulation to ensure that external power supply is economically feasible will be mandatory in order to achieve ecologic beneficial operation of sector integrated LSHPs.
Comparative study of cinnamon and paprika oleoresins encapsulated by spray chilling and particles from gas saturated solutions techniques: evaluation of physical characteristics and oleoresins release in food simulated media
Authors: Procopio Fernanda Ramalho , Klettenhammer Stefan , Ferrentino Giovanna , Scampicchio Matteo , Sobral Paulo José Amaral , Hubinger Miriam Dupas
Published: September 2022

In this study, cinnamon and paprika oleoresins were encapsulated by two technologies, respectively, spray chilling and particles from gas saturated solutions. Both technologies used palm oil as wall materials. The physical characteristics of the microparticles were compared as well as the oleoresins release behavior in high and low-fat simulated food media. The spray chilling microparticles had an average diameter of 143.7 ± 1.5 µm, spherical shape, smooth surface and passable flow property. In contrast, microparticles obtained by PGSS showed an average diameter of 105.7 ± 0.6 µm, irregular shape, porous surface, poor flow property but higher encapsulation efficiency. In evaluating the compounds released in a simulated food medium, the spray chilling particles delivered 30.7%, while PGSS reached 23.1% after one hour. Both microparticles fitted better to Kosmeyer-Peppas (R2 = 0.98 and 0.96 for spray chilling and PGSS) and Peppas-Sahlin models (R2 = 0.98 and 0.97 for spray chilling and PGSS). However, spray chilling microparticles showed a diffusion mechanism while for PGSS ones erosion was the main mechanism. Despite the different physical characteristics, both microparticles proved to be possible facilitators in delivering oleoresins in food products.
Consumption of porridge at Carcinogenic Temperature and Associated Factors in Esophageal Cancer Endemic Area in Ethiopia
Authors: Deybasso Haji Aman , Roba Kedir Teji , Belachew Tefera
Published: September 2022

Background:- The consumption of a self-reported “hot porridge” was reported as a major dietary risk factor for the increased incidence of esophageal cancerin hot spot areas in Ethiopia. However, no study has quantitatively assessed the porridge consumption temperature and associated factors among households living in endemic areas in Ethiopia and elsewhere.
Methods: - A community-based cross-sectional study was conducted from November 1 to December 30, 2020. The porridge temperature was measured using a digital thermometer (HANNA instruments®, Woonsocket, RI, US). Bivariate and multivariate logistic regression analyses were used to check the association between independent and dependent variables. Adjusted odds ratio and 95% confidence interval were used to measure of strengths of the association. Statistical significance was declared at a P-value of less than 0.05.
Result: - A total of 301 (149 Wheat, 88 Maize, and 64 Barley) utensils of porridge were measured for consumption temperature. Eighty-four percent (95% CI: (79.7, 87.7%)) of the households commenced porridge consumption at a probably carcinogenic temperature (>65 ℃). Serving porridge in a wooden bowl(Qorii) (AOR=2.0, (95%CI: (1.008, 4.310)) and wheat porridge (AOR=4.6, (95% CI:(1.936,11.406) were independent determinants of the consumption of porridge at a probably carcinogenic temperature.
Conclusion: -Substantial number of households in the study area consume porridge at an extremely higher temperature which may cause severe thermal injury to the esophagus. Households who consume wheat porridge and use a wooden serving utensil should wait until the porridge cools down to the optimum temperature for consumption.
Prediction and Optimization of Thermal Conductivity and Viscosity of Stable Plasmonic TiN Nanofluid Using Response Surface Method For Solar Thermal Application
Authors: Karmare Suhas , Patil Pradeep , Deshmukh Kishor
Published: September 2022

Nanofluids open a new dimension in solar thermal applications due to their enormous thermophysical properties. The preparation of stable, efficient, and low-cost nanofluids is an emerging area of research. According to NIMS (National Institute of Material Science) research, Titanium nitride (TiN) nanoparticles have localized surface plasmon resonance properties. It enables a superior photoabsorption feature. Titanium nitride (TiN) particles of 40–50 nm sizes were selected to prepare distilled water-based nanofluid at a 0-0.1% volume concentration range. The Thermal conductivity and viscosity of TiN nanofluids and base fluid are measured experimentally at temperatures 30℃ to 55℃. Determination of thermal conductivity and viscosity of nanofluid through experimentation is cumbersome. The present study deals with thermal conductivity and viscosity modeling of water-based stable plasmonic TiN nanofluid using the surface response method. ANOVA is used to determine the significance of input variables and their interaction. The performance of both predictive models was measured in terms of correlation coefficient (R2) and mean square error (MSE) to acknowledge the best fit. The surface response method optimizes process parameters using reliable and efficient model results for maximum heat transfer enhancement. The maximum thermal conductivity (0.8848 W/mK) and minimum viscosity (0.7822 cP) obtained at 55℃ and 0.0535% volume concentration.
The distribution of submerged macrophytes in response to intense solar radiation and salinity reveals hydrogen peroxide as an abiotic stress indicator
Authors: Asaeda Takashi , Rashid Md Harun , Liping Xia , Vamsi-Krishna Lekkala , Barnuevo Abner , Takeuchi Chizuru , Rahman Mizanur
Published: September 2022

The feasible condition for submerged macrophytes to grow is hard to understand as many environmental factors contribute to establish their distribution with different intensities.
Hydrogen peroxide (H2O2) is one of reactive oxidative species (ROS) was investigated to assess the possibility as an indicator to evaluate the submerged macrophyte species distribution in a lake. Submerged macrophytes such as Potamogeton anguillanus was abundant in Lake Shinji. The biomass distributed largest at around 1.5m deep, under low solar radiation intensity, and no biomass was found in less than 0.3 m deep, where solar radiation was high. Diurnally, H2O2concentration of the tissues varied in response to the photosynthetic active radiation (PAR) intensity, which was followed by antioxidant activities, though slightly delayed. Laboratory experiments were conducted either with different PAR intensities or with different salinity concentration. The H2O2was stably maintained for 30days up to about 200mmol/m2/s of PAR, however, gradually increased with higher PAR. The H2O2concentration became higher with higher salinity. Chlorophyll a (Chl-a) concentration, changed associated with the changing H2O2 concentration, however, following a unique negative relationship with H2O2concentration. However, if H2O2 exceeded 45mmol/g FW, then the homeostasis collapsed, then H2O2 and Chl-a significantly declined afterwards. These results indicated the negative effect of H2O2on the physiological condition of the plant. The increase in H2O2concentration was prevented by antioxidant activities, which increased with increasing H2O2 concentration.
Soil microbial communities from fertile islands under semi-arid conditions in La Guajira, Colombian Caribbean
Authors: Leal Leslie , Franco Diego C. , Vanegas Javier
Published: September 2022

Fertile islands are key ecological arrangements for slowing desertification processes in arid and semi-arid environments. These islands harbor a great variety of microorganisms that play an important role in their establishment and dynamics. The taxonomic and functional diversity of bacteria on these islands is conditioned by the nurse tree and the characteristics of their environment. However, the microbial diversity associated with these vegetation patterns is not described in the semi-arid environments of northern South America. The present study analyzed the taxonomic and functional diversity of soil microbial communities of fertile islands belonging to three species of nurse trees in the Colombian Caribbean during a wet and a dry season. DNA extraction and massive sequencing were performed from soil surface samples under the nurse plant canopy and bare soil. The SILVA database was used for taxonomic analyses, DIAMOND and the KEGG database for functional analyses, and STAMP for statistical differences. Taxonomic and functional diversity was mainly determined by seasonality and the presence or absence of vegetation. No significant differences were found among nurse plant species. The highest taxonomic abundances were recorded in the dry season under the nurse tree for the phyla Proteobacteria and Actinobacteriota, and the genera Sphingomonas, Azospira, Solirubrobacter, Flavisolibacter, and Geodermatophilus. While the highest functional potential was detected in the wet season. The presence of several biogeochemical cycling modules and unique genera suggest the presence of microniches that could be differentiated by oxygen tension and nutrient availability due to seasonality and the presence or absence of vegetation.
Early prediction model for prognosis of patients with hepatitis-B-virus-related acute-on-chronic liver failure received glucocorticoid therapy
Authors: Gao Shuai , Han Li-Yan , Fan Yu-Chen , Wang Kai
Published: September 2022

Background: Early prediction for short-term prognosis is essential for the management of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF). In this study, we aim to establish a noninvasive model for predicting the 90-day mortality in patients with HBV-ACLF received glucocorticoid therapy.
Methods: Two hundred and eighty patients with HBV-ACLF were enrolled from July 2010 to June 2022. All patients received routine medicine treatment and 204 of them received additional glucocorticoid treatment. Then, the HBV-ACLF patients received glucocorticoid treatment were randomly divided into a training cohort and a validation cohort. An early prediction model for 90-day mortality of HBV-ACLF was built in the training cohort and then validated in the validation cohort.
Results: HBV-ACLF patients received glucocorticoid treatment showed significantly better survival that those not (P < 0.01). In the training cohort, a noninvasive model was generated with hepatic encephalopathy grade, INR, total bilirubin, age and SIRS status, which was named HITAS score. It showed significantly better predictive value for 90-day mortality of HBV-ACLF than MELD score and Child–Turcotte–Pugh score in both the training cohort and validation cohort. Using the Kaplan-Meier analysis with cut-off points of 2.5 and 3.47, the HITAS score can classify HBV-ACLF patients into different groups with low, intermediate and high risk of death after glucocorticoid therapy.
Conclusions: We proposed a HITAS score, which was an early prediction model for the prognosis of HBV-ACLF. It might be used to identify HBV-ACLF patients with favorable responses to glucocorticoid treatment.
Supervised Hybrid Framework for Addressing Word Sense Ambiguity with Special Focus on English-to- Sanskrit Machine Translation
Authors: Maurya Archana Sachindeo , Bahadur Promila , Sharma Rajat
Published: September 2022

One of the most important application of Natural Language Processing is Machine Translation (MT). It is an automated process of translation through a computer system. Machine Learning (ML) is one of the recent methods used in MT, and it has become a buzzword in the area of research over the last numerous years. Ambiguity is a major challenge in MT. ML has given promising results in terms of system learning and predicting results. The text classification technique in Machine Learning is considered as one of the most important methods to resolve Word Sense Disambiguation (WSD). The role of Dataset both as Training and Test data is important to predict the required results. We have taken data size of 2000 sentences which is further divided as training and test data. The dataset plays a pivotal role in validating the output of the system. We have also done an analysis on supervised machine learning text classification algorithms namely Naïve Bayes’, Decision Tree, Support Vector Machine (SVM), K-nearest Neighbor (KNN), Neural Network, Logistic Regression and Random Forest. The accuracy of the given algorithms range between sixty-eight to eighty-four percent. Further, we have also done analysis on proposed a “hybrid model” for prediction of POS ambiguity. In the proposed model, we have combined the Naïve Bayes’, Support Vector Machine and Decision Tree algorithms to achieve better results. The proposed model has reported an accuracy of eighty-five percent. The accuracy of the algorithms and model is tested using tenfold cross-validation method. The model has also reported high precision, recall and F-score in comparison to all supervised machine learning classification algorithms. The correctness of algorithm and model is tested in terms of the total number of correct POS predicted. The algorithms and proposed model are analyzed with the help of machine learning tool developed named as “AmbiF”.
Safety, Tolerability and Pharmacokinetics of Single-dose Oral SYHA1402 in Chinese Healthy Subjects
Authors: Liang Beibei , Wang Jin , Zhang Guanxuanzi , Wang Rui , Cai Yun
Published: September 2022

Objective
To assess the safety, tolerability and pharmacokinetics of a single dose of SYHA1402 in Chinese healthy subjects.
Methods
This was a randomized, double-blind, placebo-controlled, single-ascending dose study in healthy subjects. Subjects received a single dose of 25mg (n = 4), 50mg (n = 8), 100mg (n = 8), 200mg (n = 8), 400mg (n = 8), 800mg (n = 6) or matching placebo (n = 12, 2 in each dose group). We assessed safety and tolerability throughout the study. The pharmacokinetic (PK) parameters of SYHA1402 were estimated using non-compartmental analysis.
Results
In all, 54 subjects were enrolled and completed the study. Specifically, there were no deaths, serious adverse events, or withdrawals from study due to adverse events. All treatment-emergent adverse events were mild. The most common drug-related adverse event was sinus bradycardia. The time to maximum concentration ranged from 1.13 to 2.25 h. The terminal elimination half-life range of SYHA1402 was 1.51 h to 4.70 h. SYHA1402 exhibited nonlinear PKs with less than dose-proportional increases in exposure after single oral doses of 25 mg to 800 mg. Fe0 − 72h from urine of SYHA1402 in each dose group from 25 mg to 800 mg was 64.08%, 57.97%, 59.28%, 24.64%, 8.49%, 7.15%, respectively.
Conclusion
Single dose of SYHA1402 was well tolerated and safe over the dose range of 25–800 mg. More than 50% of the unchanged SYHA1402 were excreted in urine within the dose range of 25–100 mg. With the dose increasing to 800 mg, the urine excretion amount of SYHA1402 gradually tends to saturation.
Trial registration number
NCT03988413 (https://www.clinicaltrials.gov/)
Trial registration date
June 17, 2019
Date of first patient’s enrollment:
August 5, 2019
A Simple Diagnostic for Assessing Internal Dynamical Constraints on Tropical Cyclone Intensity
Authors: Lu Ping , Done James M. , Jing Renzhi , Yang Long , Li Yuanlong , Wang Danyang , Lin Yanluan
Published: September 2022

The upper bound of tropical cyclone (TC) intensity is usually estimated from the available thermodynamic energy in the environment. But internal dynamics of the vortex also put constraints on TC intensity. Here we show quantitatively the internal constraints on maximum wind speed using a simple diagnostic computed from maximum wind speed, radius of maximum wind, and latitude of the storm. With global observations and reanalysis data of TCs during 2001-2020, this diagnostic is found to occur in more than half of the storms with rapid intensification, and coincides with drastic halt of rapid intensification despite little change in the environment (e.g., sea surface temperature, relative humidity, and wind shear). This diagnostic highlights the importance of pressure-wind relationship in internal dynamical control on storm intensity, and provides a valuable tool to improve the understanding, modeling, and prediction of storm intensity evolution.
Obstacle Avoidance and Navigation of Bio-inspired Autonomous Underwater Vehicle using Fuzzy Logic Controller and Neuro-Fuzzy controller
Authors: V Aruna M
Published: September 2022

Autonomous Underwater Vehicles (AUVs) are pre-programmable, robotic vehicles that can float, drive, or slide through the sea without operators and have real-time control, depending on their configuration. Biologically inspired AUVs (BAUVs) are a relatively new invention in the field of underwater vehicles that do away with propellers. Bio-inspired AUVs can be employed for high-speed and low-speed applications with exceptional propulsive efficiency. The navigation control mechanisms of a novel Bio-mimetic autonomous underwater vehicle were investigated in this work. In order to design a navigational system for the vehicle after avoiding obstacles, Fuzzy Logic Controller (FLC) and Neuro-Fuzzy controller approaches are utilized.
Anxiety and Depression in Psychiatry Residents of Universitas Gadjah Mada During Early COVID-19 Pandemic
Authors: Marchira Carla Raymondalexas , Aulia Afkar , Irwen Julian R. , Mediola Fiddina
Published: September 2022

Health workers at the forefront in handling COVID-19 cases are particularly vulnerable to contracting COVID-19 infections and mental health problems. Psychiatry residents who studied and worked in hospitals were expected to provide mental health and psychosocial treatments to health workers and COVID-19 patients. However, it was necessary to know the mental status of psychiatric residents in uncertain situations during the COVID-19 pandemic. We aimed to observe anxiety and depression in psychiatric residents of Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada who worked in Sardjito Hospital during the COVID-19 pandemic. This quantitative non-experimental study was conducted using cross sectional and descriptive analytic design. All 45 psychiatry residents of Universitas Gadjah Mada participated in the study and completed the Taylor Manifest Anxiety Scale (TMAS) and Patient Health Questionnaire-9 (PHQ-9). We used Chi-squared test, Student T-test and Pearson Correlation to understand correlations between demographic characteristics with depression and anxiety level. We found that only age was negatively correlated with the degree of anxiety (r =-0.364, p = 0.014). However, some other variables might be correlated with several behaviors related to anxiety and depression. More study is needed to find the reasons for these correlations and to prevent mental health problems in residents.
Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis
Authors: Wang Wei , Luo Haixia , Chang Jingjing , Yang Xin , Zhang Xiu , Zhang Qingmei , Zou Binbin , Li Yuanxing , Zhao Yueyang , Liu Jianbin , Hao Min
Published: September 2022

Background Circular RNAs (circRNAs) are known to play a crucial role in a variety of malignancies. However, the precise role of circRNAs in cervical squamous cell carcinoma (CSCC) remains largely unknown. Methods The expression of circ0001955 was determined by real-time quantitative PCR and fluorescence in situ hybridization. To examine the effects of circ0001955 on CSCC metastasis and growth, functional experiments were conducted in vitro and in vivo. Mechanistically, nucleocytoplasmic separation, dual luciferase reporter assay, RNA antisense purification experiments, and rescue experiments were performed to confirm the interaction between circ0001955, miR-188-3p, and NCAPG2 in CSCC. Results Here, we demonstrated that a circRNA derived from the CSNK1G1 gene (circ0001955) is significantly upregulated in CSCC. The overexpression of circ0001955 promotes tumor proliferation and metastasis in vitro and in vivo, whereas the knockdown of circ0001955 exerts the opposite effects. Mechanistically, circ0001955 competitively sponges miR-188-3p and prevents miR-188-3p from reducing the levels of NCAPG2 and activating the AKT-mTOR signaling pathway involved in the proliferation and epithelial mesenchymal transformation. Conclusions Our results demonstrate that circ0001955 plays a vital role in the development and metastasis of CSCC, suggesting that it may serve as a therapeutic target in CSCC.
Micrometer-level localization system with ultra-stable frequency synchronization net
Authors: Zhao Qin , Chen Yiting , Wang Zhengbo , Wang Lijun
Published: September 2022

The ultra-high accuracy indoor and outdoor localization is fundamental for a variety of applications such as industrial automation, Internet of Things and structure monitoring. However, many approaches based on optical methods, ultrasound and computer vision may suffer from insufficient coverage, obstruction or high computing load. In traditional GNSS and radar-like microwave system, further efforts are needed to enhance the accuracy and availability. Now we demonstrate a microwave localization system with ultra-stable frequency synchronization net based on an inverse GNSS scheme. Such a combination effectively improves both the coverage and accuracy since the frequency synchronization net in free space can cover kilometer-level area and serves as reference for phase difference process. The stability of frequency synchronization net is better then $10^{-13}$/s. The ranging resolution is 25 micrometers and the Mean Squared Error (MSE) of three-dimensional localization is 16 micrometers.
Exploring the factors influencing adherence to oral anticancer drugs in patients with digestive cancer: a qualitative study
Authors: NIZET Pierre , TOUCHEFEU Yann , PECOUT Solange , CAUCHIN Estelle , BEAUDOUIN Eva , MAYOL Séverine , FRONTEAU Clémentine , HUON Jean-François
Published: September 2022

Purpose
The aim of this study was to explore the beliefs, perceptions and representations of patients in order to identify the determinants of oral anticancer drugs adherence and to take action in current practice to improve patient support in digestive oncology.
Methods
We constructed a semi-directed interview guide which aimed to explore the patient's relationship with medication, their health history, their experiences at the time of the announcement of treatment, their confidence, their fears, their motivations to adhere to their treatment and the constraints linked to their treatment. The data were analysed and discussed using a thematic approach.
Results
Seventeen patients agreed to participate in the study. The median age was 60 years. Ten patients had colorectal cancer, 3 patients had hepatocellular carcinoma, 3 patients had gastrointestinal stromal tumour and 1 patient had neuroendocrine pancreatic tumor. We identified five categories of factors influencing adherence: demographic and socioeconomic, disease-related, treatment-related, care system-related, and patient representation and pathways’ factors. A majority of patients emphasised the importance of family support in the adherence process and the convenience of per-os treatment compared to other intravenous treatments. However, several negative determinants emerged such as the toxicity of the treatment, fears of forgetting to take the medication, difficulties with the galenic formulation and negative beliefs of the family.
Conclusion
This study demonstrates the need to address the different dimensions of the patient in order to understand his or her behaviour with regard to adherence and to identify the levers for improvement.
O Prato do Trabalhador: Conectando Urbano e Rural por meio do Vale-Alimentação da Papayas
Authors: Siqueira Angélica Cristina da , Hendler Vanessa Magnus , Scalon Liamara , Moura Caetano Flores de , Cruz Fabiana Thomé da
Published: September 2022

Apesar do reconhecimento sobre as relações entre o sistema alimentar, a saúde e a sustentabilidade do ambiente, a construção de estratégias integradas para superação de problemas enfrenta dificuldades. Em um cenário de incertezas acerca da continuidade de políticas públicas promotoras da agroecologia e da alimentação adequada e saudável, vislumbra-se como horizonte o fortalecimento de iniciativas, em âmbito local, para a promoção de sistemas alimentares sustentáveis. Nesse contexto, o Programa de Alimentação do Trabalhador assume relevância pelo potencial de alcançar distintos elos do sistema alimentar, beneficiando a alimentação das famílias. Com o objetivo de explorar alternativas às relações de produção e consumo para promover saúde rural e urbana, a pesquisa dedicou-se a aprofundar o conhecimento acerca de uma experiência emergente no que diz respeito à alimentação do trabalhador. Para tal, foi realizado um estudo de caso sobre o modelo de vale-alimentação adotado pelo empreendimento Papayas no município de Porto Alegre (RS), utilizando-se entrevistas semiestruturadas e análise de conteúdo. Os resultados apontam o potencial da iniciativa analisada como modelo a ser multiplicado, reforçando o papel significativo que a alimentação do trabalhador pode assumir no resgate de conexões urbano-rural e no fortalecimento de sistemas alimentares sustentáveis promotores de saúde e de desenvolvimento rural.
As Políticas Públicas de Inovação com Foco na Indústria Brasileira
Authors: Souza Gabriel Cezar de Araujo de , Teixeira Joselia Elvira
Published: September 2022

A inovação tem sido adotada como estratégia competitiva das empresas e países. O Sistema Nacional de Inovação coaduna esforços privados e públicos para aumentar a capacidade inovadora do país. Este estudo tem como objetivo identificar as principais políticas e instrumentos públicos de desenvolvimento de inovações com foco na análise dos dados da indústria. Metodologicamente, optou-se pela pesquisa bibliográfica e documental para identificar as principais políticas públicas de inovação criadas no Brasil e a pesquisa quantitativa, por meio da análise comparativa das Pintecs dos interstícios de 2000 a 2017, com foco no setor industrial do Brasil, além de dados de investimento do governo em C&T, P&D e ACTC do Ministério da Ciência Tecnologia e Inovações. A partir da análise descritiva dos dados da Pintec para a indústria, pode-se compreender que o modelo de inovação fechada ainda predomina no Brasil. Os dados mostraram que a inovação de produto predominantemente é realizada dentro das organizações sem compartilhamento com outras empresas ou institutos de pesquisa. No período de 2000 a 2017 os investimentos governamentais concentraram-se, em maior parte, na área de C&T, com 35% dos dispêndios. Em 2017 a despesa do governo federal do Brasil em P&D era de 1,34% em relação ao PIB. Somente um pouco mais de um terço das indústrias inovaram nos resultados das últimas Pintecs. A maioria das indústrias inovou com recursos próprios, não com recursos advindos de políticas governamentais. Entre os mecanismos de políticas públicas para inovação mais utilizados para inovar pelas empresas está o financiamento para a compra de máquinas e equipamentos.
Uma Rede Intersetorial: Performances no Ideário da Proteção Social
Authors: Zucchetti Dinora Tereza , Lemes Marilene Alves
Published: September 2022

O texto apresenta reflexões sobre uma rede de serviços assistenciais, de tipo intersetorial, presente num território de uma cidade da grande Porto Alegre/RS, objetivando problematizar o ideário da proteção social que emerge de relações interinstitucionais. Descreve fluxos de discussões por meio do procedimento metodológico da cartografia (KASTRUP, 2008; ALMEIDA, 2013), considerando os registros de atas de reuniões e diários de pesquisa referentes aos anos de 2018 e 2019. Resultado de uma investigação mais ampla, o artigo evidencia recursos que são colocados em movimento e a relação desses com os ditames da Política de Assistência Social, visando ao enfrentamento de dilemas que afligem sujeitos desprovidos do acesso aos direitos fundamentais. Nem sempre, contudo, tal proposição é considerada e objetivamente intencionada, prevalecendo, em muitas situações, o ideário de uma proteção assentada em práticas prescritivas, numa abordagem baseada na necessidade.
FEW Nexus e sustentabilidade na agricultura familiar: um estudo de caso na PoliFeira da UFSM
Authors: Soares Henrique Martins de , Sliva Tania Nunes da
Published: September 2022

O objetivo deste estudo foi analisar o impacto sustentável da PoliFeira da UFSM nos agricultores familiares participantes e na comunidade local. Buscando alcançar tal objetivo, utilizou-se o estudo de caso e a técnica de análise de conteúdo. Os dados primários foram coletados por meio de entrevistas semiestruturadas com agricultores, organizadores, consumidores e representante da universidade. Já os dados secundários foram documentos, como planilhas financeiras e relatórios de atividade. Segundo os resultados analisados, a PoliFeira impacta sustentavelmente os agricultores participantes e a comunidade local. Primeiramente isso ocorre porque o impacto com relação à energia, à água e ao alimento é significativo, uma vez que a PoliFeira auxilia os agricultores no uso mais eficiente da água, na conscientização quanto à energia renovável e na transição para uma produção limpa. Ademais, o impacto econômico e, consequentemente, na qualidade de vida dos agricultores, foi também relevante. Com relação ao impacto social, a PoliFeira proporciona aos agricultores laços de amizade – entre si e com os consumidores – e reconhecimento. Já com relação aos consumidores, o impacto foi positivo, pois a feira garante um alimento de qualidade e a conscientização agroecológica. Considera-se que a PoliFeira é uma iniciativa bem-sucedida da UFSM e um exemplo a ser seguido por outras universidades e gestões públicas devido ao seu caráter socioeducativo e compromisso com a agricultura sustentável. Por fim, o estudo comprova a relevância da abordagem FEW Nexus na análise do desenvolvimento sustentável para a agricultura familiar e da interação entre universidade e comunidade local.
As Políticas Públicas na Agricultura Familiar do Território da Cidadania da Bacia Leiteira Alagoana: PRONAF, PNAE, PAA e Programa Bolsa Família
Authors: Rodrigues dos Santos Janayson
Published: September 2022

A região semiárida do território alagoano apresenta baixos índices de desenvolvimento e alta vulnerabilidade econômica. Este artigo busca fazer uma análise de políticas públicas no âmbito da agricultura familiar, tendo como objetivo observar como foi a evolução do acesso ao Pronaf, PAA, PNAE e Programa Bolsa Família, nos municípios de Belo Monte, Cacimbinhas, Major Isidoro e Pão de Açúcar, os quais integram a região que foi denominada de Território da Cidadania da Bacia Leiteira Alagoana. A pesquisa parte do pressuposto de que estas políticas públicas fortalecem o segmento da agricultura familiar em âmbito local, por meio do acesso ao crédito para produção, estímulo para a comercialização e proteção social. Para a efetivação da pesquisa foi realizada, inicialmente, uma revisão bibliográfica e, em seguida, um levantamento de dados secundários em fontes oficiais, como FNDE, Banco Central, Ministério do Desenvolvimento Social, Conab e IBGE. Para complementar as informações sobre a evolução do acesso às políticas públicas mencionadas, foi efetuado um levantamento de dados primários por meio de entrevistas e questionários semiestruturados. Foram entrevistados representantes de agricultores familiares e das Secretarias Municipais de Agricultura e Educação nos quatro municípios. Os resultados da pesquisa demonstraram que o Pronaf, o PNAE e o Programa Bolsa Família têm forte atuação nos municípios pesquisados, mas há oportunidades de ampliação no acesso às políticas, sendo uma das sugestões a postura mais ativa de gestores públicos nas Secretarias Municipais de Agricultura e Educação; ações que poderiam contribuir para promover a agricultura familiar em municípios de grande vulnerabilidade econômica e social como os pesquisados.
Teknik Pengelolaan Kelas Besar di Sekolah Dasar
Authors: Juwita Ratna
Published: September 2022

Kemampuan mengelola kelas merupakan salah satu kompetensi yang menjadi salah satu masalah yang mempengaruhi kualitas proses pembelajaran. Penelitian kualitatif ini menggunakan wawancara dan observasi untuk mengetahui teknik guru dalam mengelola kelas besar di Sekolah Dasar. Hasil penelitian ini menunjukkan bahwa teknik guru dalam mengelola kelas besar adalah dengan cara memberikan contoh langsung kepada peserta didik untuk membersihkan kelas dan halaman sehingga suasa kelas bersih dan rapi, membiasakan peserta untuk selalu disiplin dalam pembelajaran tematik. Selain itu, perangkat pembelajaran dan sumber belajar yang digunakan juga cukup beragam, baik yang sederhana maupun yang digital. Ruang kelas juga dihias seindah mungkin dan karya siswa juga dipajang di dinding kelas. Guru juga selalu mengutamakan keaktifan peserta didik selama proses pembelajaran tematik. Sirkulasi udara tetap bersih karena jendela selalu dibuka dan dibersihkan setiap hari sebelum dan sesudah proses pembelajaran. Teknik pengelolaan kelas besar tersebut tekag mampu membuat peserta didik tetap fokus dalam pembelajaran tematik dan memberikan pengalaman belajar yang bermakna dan menyenangkan, sehingga diharapkan semua guru yang mengajar di kelas besar bisa menerapkan teknik pengelolaan kelas tersebut.Abstract: The ability to manage the class is one of the competencies that affects the quality of the learning process. This qualitative research uses interviews and observations to determine the teacher's techniques in managing large classes in elementary schools. The results of this study indicate that the teacher's technique in managing large classes is to give direct examples to students of how to clean the classroom and yard so that the classroom atmosphere is clean and tidy, familiarizing participants with the need to always be disciplined in thematic learning. In addition, the learning tools and learning resources used are quite diverse, both simple and digital. Classrooms are also decorated as beautifully as possible, and student work is also displayed on the classroom walls. Teachers also always prioritize the activeness of students during the thematic learning process. Air circulation is kept clean because the windows are always opened and cleaned every day before and after the learning process. The large class management technique is determined to be able to keep students focused on thematic learning and provide a meaningful and enjoyable learning experience, so it is hoped that all teachers who teach in large classes can apply these classroom management techniques.
Medicinal Plants and Drug Discovery
Authors: Ajani Emmanuel O.
Published: September 2022

Emerging communicable diseases, such as Ebola and Coronavirus InfectionDisease (COVID-19), and non-communicable diseases related to diet and lifestyle, e.g.,diabetes, have been increasing over the last two decades, having a great negativeimpact on the health services, which are already over-stretched. This again has beencompounded by some largely unresolved diseases, such as malaria and HIV/AIDS,which are common parasitic and infectious diseases in many developing countries.Over several years, natural medicine has been a dependable alternative in theprevention and treatment of diseases and has been widely recognized as important fordrug discovery and development. Over the world, traditional medicine has largelydepended on natural products. The structural diversity and biological activity of naturalproducts have made them a valuable source of drugs and drug leads. Several activecompounds have been isolated from natural products. Among them, some follow theirtraditional uses while some others do not. For many years, plant’s bioactivecompounds, otherwise referred to as secondary metabolites, have been the source ofcountless compounds and leads for drug discovery. The process of drug discoveryincludes the identification of a lead compound, which is then proposed for drugdevelopment. Drug discovery, therefore, encompasses moving from a screening hit to acompound becoming a therapeutic agent. It is a process that requires expertise andexperience. In modern drug discovery research, techniques commonly employedinclude combinatorial chemistry, high-throughput screening, bioinformatics,proteomics and genomics.
The Use of Plant Secondary Metabolites in the Treatment of Bacterial Diseases
Authors: Charlene Pillay , Nishani Ramdhani , Seema Singh
Published: September 2022

Plants produce an array of secondary metabolites identified as possible antimicrobialagents that are used across the globe to treat numerous diseases and ailments.These secondary metabolites serve as unique commercial sources of variouspharmaceuticals, food additives and flavouring agents, and possess diverse industrialapplications. Alkaloids, flavonoids, and polyphenols are secondary metabolites shownto attack numerous gram-positive and gram negative bacteria in response to microbialinfections. Secondary plant metabolites have a detrimental effect on microbial cells inseveral ways, such as alteration of the structure and function of the cytoplasmicmembrane as well as DNA/RNA synthesis, interference with intermediary metabolism,interaction with membrane proteins, a disruption in the movement of protons leading toion leakage, enzyme synthesis inhibition, the clotting of cytoplasmic components andinterference in typical cell communication. This ultimately results in cell death. Thefocus of this chapter is to provide an overview of the function and benefits of plantsecondary metabolites as therapeutic agents to combat pathogenic bacterial infections.