bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling variations of emergency attendances using data on community mobility, climate and air pollution
Authors: Weismann Dirk , Möckel Martin , Paeth Heiko , Slagman Anna
Published: November 2023

Air pollution is associated with morbidity and mortality worldwide. We investigated the impact of improved air quality during the economic lockdown during the SARS-Cov2 pandemic on emergency room (ER) admissions in Germany. Weekly aggregated clinical data from 33 hospitals were collected in 2019 and 2020. Hourly concentrations of nitrogen and sulfur dioxide (NO2, SO2), carbon and nitrogen monoxide (CO, NO), ozone (O3) and particulate matter (PM10, PM2.5) measured by ground stations and meteorological data (ERA5) were selected from a 30 km radius around the corresponding ED. Mobility was assessed using aggregated cell phone data. A linear stepwise multiple regression model was used to predict ER admissions. The average weekly emergency numbers vary from 200 to over 1600 cases (total n = 2,216,217). The mean maximum decrease in caseload was 5 standard deviations. With the enforcement of the shutdown in March, the mobility index dropped by almost 40%. Of all air pollutants, NO2 has the strongest correlation with ER visits when averaged across all departments. Using a linear stepwise multiple regression model, 63% of the variation in ER visits is explained by the mobility index, but still 6% of the variation is explained by air quality and climate change.
Analysis of liquid–vapor mixed migration mechanism in unsaturated soil based on the effect of temperature on soil microstructure
Authors: Zhang Jianxun , Mao Xuesong
Published: November 2023

Moisture migration in unsaturated soils is a result of the interaction between temperature and soil microstructure. In order to reveal the mechanism of moisture increase of subgrade soils under diurnal cycle conditions, a series of macro and microscopic tests were carried out on the unsaturated silty clay and sand soil, including liquid–vapor mixed migration tests simulating a one-dimensional subgrade, environmental scanning electron microscope (ESEM), and matrix suction test. Then, the soil microstructure in microscopic images was investigated using the particle (pores) and cracks analysis system (PACS). Next, the relationship between the thermal effects of the soil–water characteristic curve (SWCC) and changes in soil microstructure was analyzed. Finally, the change mechanism of liquid–vapor mixed migration based on the change in soil microstructural under thermal effects was analyzed. The results showed under the diurnal cycle, both the silty clay and sand soil columns appeared in the phenomenon of a “diurnal cycle of water vapor migration”, which led to moisture accumulation at the top of the soil layer. In silty clay soil column, moisture was primarily driven by water vapor pressure and migrated upwards. Additionally, moisture redistribution led to changes in soil microstructure, which in turn influenced the process of moisture migration. The moisture content in the upper soil layer increased making both inter-aggregate and intra-aggregate pores decrease. The moisture content in the lower soil later decreased, leading to the water-holding capacity of the lower soil layer to increase. So, the moisture migration gradually decreased at night. In the sand soil column, moisture migration was mainly driven by gravity potential and migrated downwards. Moisture redistribution made inter-aggregate pore and matrix suction of the upper soil layer increase, leading to an increase in moisture migration at night.
Geospatial distribution and machine learning algorithms for assessing water quality in surface water bodies of Morocco
Authors: El Morabet Rachida , Barhazi Larbi , Bouhafa Soufiane , Dahim Mohammed Abdullah , Khan Roohul Abad , Khan Nadeem A.
Published: November 2023

Surface waterbodies being primary source of water for human consumption are being investigated for its quality globally. This study evaluated water quality in three rivers (River Nfifikh, Hassar and El Maleh) of Mohammedia prefecture, Morocco in terms of heavy metals occurrence during two seasons of winter and spring. The heavy metals analyzed were cadmium, iron, copper, zinc, and lead. Heavy metal pollution index was derived to quantify water quality and pollution. Hazard quotient and carcinogenic risk were calculated to determine possible health risk. Modelling and prediction were performed using random forest, support vector machine and artificial neural network. The heavy metal concentration was lower in the winter season than in the spring season. Heavy metal pollution index (H.P.I.) was in the range of 1.5–2 during the winter season and 2–3 during the spring season. In the Nfifikh river, Cd2+ and Fe were the main polluting heavy metal. H.Q. was < 1 in all three rivers, which signified no adverse health effect from exposure to heavy metals. However, carcinogenic risk assessment revealed that 1 in every 100 people was susceptible to cancer during the life span of 70 years. Based on the control point reference, it was found that Mohammedia prefecture as river water was already contaminated before it entered the prefecture boundary. This was again validated with the water lagoon Douar El Marja which is located near the industrial zones of Mohammedia prefecture. Future studies are required to investigate pollution of rivers prior to their entry in Mohammedia prefecture to identify potential source and adopt mitigation measures accordingly.
Intracellular and in vivo activities of oxazolidinone drugs against Mycobacterium avium complex infection
Authors: Lee Ju Mi , Kim Lee-Han , Kim Su-Young , Jhun Byung Woo , Lee Wonsik , Shin Sung Jae
Published: November 2023

The prevalence of Mycobacterium avium complex-pulmonary disease (MAC-PD) has become a growing concern worldwide, and current treatments involving macrolides (clarithromycin [CLR] or azithromycin), ethambutol, and rifampicin have limited success, highlighting the need for better therapeutic strategies. Recently, oxazolidinone drugs have been identified as novel anti-tuberculosis drugs effective against drug-resistant M. tuberculosis. However, the effects of these drugs against MAC are still controversial due to limited data. Here, we first evaluated the intracellular anti-MAC activities of two oxazolidinone drugs, linezolid (LZD) and delpazolid (DZD), against 10 macrolide-susceptible MAC strains and one macrolide-resistant M. avium strain in murine bone marrow-derived macrophages (BMDMs) and found that both drugs demonstrated similar potential. The synergistic efficacies with CLR were then determined in a chronic progressive MAC-PD murine model by initiating a 4-week treatment at 8 weeks post-infection. Upon assessment of bacterial burdens and inflamed lesions, oxazolidinone drugs exhibited no anti-MAC effect, and there was no significant difference in the synergistic effect of CLR between LZD and DZD. These findings suggest that oxazolidinone drugs inhibit intracellular bacterial growth, even against macrolide-resistant MAC, but their clinical application requires further consideration.
Strategies for developing sustainable communities in higher education institutions
Authors: Biancardi Alberto , Colasante Annarita , D’Adamo Idiano , Daraio Cinzia , Gastaldi Massimo , Uricchio Antonio Felice
Published: November 2023

Higher education institutions (HEIs), based on learning, innovation, and research, can support the progress of civil society. Many HEIs are implementing sustainability practices and projects to counteract climate change, often involving youth participation. The present study aimed at identifying how sustainable communities may be fostered in a university setting. To that end, a questionnaire was administered to engineering students at the start and end of a course on energy issues, assessing their perceptions of sustainability using multi-criteria decision analysis. The results showed that students placed greater value on sustainability at the end of the course. Additionally, the findings highlight that the implementation of projects aimed at tackling real problems may be useful for disseminating knowledge and sustainable practices. The main implications of this study indicate that sustainable communities in academia lay on six foundational pillars: sustainable education, energy (and resource) independence, subsidies in support of the green economy, initiatives aimed at reducing the carbon footprint, energy community development, and new green professional opportunities.
Circulation dampened heat extremes intensification over the Midwest USA and amplified over Western Europe
Authors: Singh Jitendra , Sippel Sebastian , Fischer Erich M.
Published: November 2023

Globally heat extremes have intensified in recent decades. However, while Western Europe shows a remarkably strong intensification of heat extremes, the Midwest United States experienced only weak warming of warmest nighttime and even a weak decrease in the intensity of daytime heat extremes since 1979. Here, we show that for daytime heat extremes in the Midwest United States atmospheric circulation induced ~1 °C cooling since 1979, reversing the thermodynamic warming trend. The observed circulation-induced trend is outside the multi-model range and the overall trend at the very low end of it. In Western Europe circulation greatly amplified warming by ~1 °C, accounting to one third of observed trend. The observed circulation- and thermodynamic-induced trends, as well as the total observed trends are at the high end of the model range in Western Europe. Understanding whether the strong circulation-induced trends are externally forced or unforced internal variability remains key to constrain future trends in heat extremes.
Electrokinetic focusing of SARS-CoV-2 spike protein via ion concentration polarization in a paper-based lateral flow assay
Authors: Rahn Kira L. , Osman Sommer Y. , Pollak Quinlan G. , Anand Robbyn K.
Published: November 2023

We report a method for electrokinetic focusing of a SARS-CoV-2 direclty over a test line comprising ACE receptors in a lateral flow assay. The method and design rules derived from this study are broadly applicable to a wide range of charged analytes.
Size-dependent therapeutic efficiency of 223Ra-labeled calcium carbonate carriers for internal radionuclide therapy of breast cancer
Authors: Akhmetova Darya R. , Mitusova Kseniya A. , Postovalova Alisa S. , Ivkina Arina S. , Muslimov Albert R. , Zyuzin Mikhail V. , Shipilovskikh Sergei A. , Timin Alexander S.
Published: November 2023

The size of drug carriers strongly affects their biodistribution, tissue penetration, and cellular uptake in vivo.
Molar excess of coordinating N-heterocyclic carbene ligands triggers kinetic digestion of gold nanocrystals
Authors: Arabzadeh Nosratabad Neda , Jin Zhicheng , Arabzadeh Hesam , Chen Banghao , Huang Cheng , Mattoussi Hedi
Published: November 2023

Incubation of AuNPs with NHC-based ligands in large molar excess dislodges surface atoms, promotes formation of stable NHC–Au complexes, ultimately leading to complete digestion of the nanocrystals.
Adenine–adenine, adenine–cytosine and cytosine–cytosine intrastrand crosslinks induced by a photoactivatable Pt(iv) anticancer prodrug
Authors: Lin Jiafan , Huang Jingjing , Zhang Jishuai , Qin Xinrui , Ma Ziqi , Wu Xiaoqin , Wang Fuyi , Zhao Yao , Wu Kui
Published: November 2023

Mass spectrometric analysis revealed the 1,3-ATA/ATC/CTA/CTC crosslinks in trinucleotides by trans-[PtII(py)2]2+ from a photoactivatable diazido Pt(iv) anticancer prodrug upon irradiation.
Recent progress of Ni-based nanomaterials for the electrocatalytic oxygen evolution reaction at large current density
Authors: Wang Cheng , Fei Zhenghao , Wang Yanqing , Ren Fangfang , Du Yukou
Published: November 2023

A comprehensive review regarding the design and application of various Ni-based electrocatalyst toward OER with large current densities is organized.
A novel covalent organic framework for efficient photocatalytic reduction of Cr(vi) and synergistic removal of organic pollutants under visible light irradiation
Authors: Lu Wen , Wang Chen , Bai Yuxuan , Xie Chengde , Zhang Zhixiong , Song Wenhui , Wang Jianjun
Published: November 2023

Polluted wastewater containing organic pollutants and heavy metals is increasing and harms environmental ecosystems and human health.
Association between dietary patterns and chronic kidney disease combined with hyperuricemia
Authors: Luo Mengrui , Liu Tiancong , Ju Hao , Xia Yang , Ji Chao , Zhao Yuhong
Published: November 2023

Chronic kidney disease (CKD) combined with hyperuricemia is a concerning health issue, but the association between this condition and dietary patterns remains poorly understood.
Facile development of copper ferrite nanospheres for UV light-driven photocatalytic degradation of cloxacillin sodium
Authors: Naeem Muhammad , Haider Faheem , Ashraf Adnan , Ahmed Saeed , Batoo Khalid Mujasam , Siddiqui Waseeq Ahmad , Imran Muhammad , Raza Muhammad Asam , Pervaiz Muhammad , Hussain Sajjad
Published: November 2023

UV-mediated cloxacillin sodium degradation pathway.
Homochiral hierarchical molecular assemblies through dynamic combination of conformational states of a single chiral building block at the liquid/solid interface
Authors: Maeda Matsuhiro , Sato Kazuya , De Feyter Steven , Tahara Kazukuni
Published: November 2023

We herein report the construction of homochiral, hierarchical self-assembled molecular networks at the liquid/graphite interface using a single chiral molecular building block through dynamic self-sorting.
The thermoelastic properties of monolayer covalent organic frameworks studied by machine-learning molecular dynamics
Authors: Wang Bing , Ying Penghua , Zhang Jin
Published: November 2023

The machine-learned neuroevolution potential with high efficiency and accuracy has been developed to study the elastic properties of finite-sized monolayer covalent organic frameworks at various temperatures.
Metal oxide-embedded carbon-based materials for polymer solar cells and X-ray detectors
Authors: Aftab Sikandar , Liu Hailiang , Vikraman Dhanasekaran , Hussain Sajjad , Kang Jungwon , Al-Kahtani Abdullah A.
Published: November 2023

This study examines the effects of hybrid nanoparticles made of NiO@rGO (reduced graphene oxide) and NiO@CNT (carbon nanotubes) on PCDTBT and PCBM active layers in glass/ITO/HTL/active-layer/LiF/Al structured bulk heterojunction (BHJ) polymer solar cells (PSCs) and X-ray photodetectors.
Recent advances in ring-opening of cyclobutanone oximes for capturing SO2, CO or O2via a radical process
Authors: Zhong Long-Jin , Fan Jian-Hong , Chen Pu , Huang Peng-Fei , Xiong Bi-Quan , Tang Ke-Wen , Liu Yu
Published: November 2023

In this review, we conclude recent main themes in trapping SO2, CO or O2 by cyanoalkyl radicals, which are produced from iminyl-radical-triggered C–C bond cleavage of cyclobutanone oxime derivatives.
Fabrication of poly(4-vinylpyridine)-b-polystyrene-b-poly(4-vinylpyridine) triblock copolymer particles via three-dimensional soft confined self-assembly
Authors: Guo Lei , Xia Dingli , Wang Yaping , Ding Shipeng , Xu Junting , Zhu Yutian , Du Binyang
Published: November 2023

Fabrication of VmS24.2kVm (m = 3.0k, 6.3k, 7.9k, 13.4k) triblock copolymer particles via three dimensional soft confined self-assembly at various CTAB concentrations.
Pd-catalyzed vinyl C–H amination with diaziridinone
Authors: Wang Jianjun , Hong Huiying , Hu Daguo , Liu Jieling , Liu Wei , Shi Yian
Published: November 2023

3-Amino-N-(quinolin-8-yl)acrylamides are obtained with up to 78% yield via Pd-catalyzed vinyl C–H amination with di-tert-butyldiaziridinone as a nitrogen source.
Metal-free hydrophosphorodithiolation of alkynes with P4S10 and alcohols leading to vinyl phosphorodithioates
Authors: Qu Chengming , Wang Yalu , Lv Yufen , Yue Huilan , Wei Wei , Yi Dong
Published: November 2023

A facile and metal-free hydrophosphorodithiolation of alkynes with P4S10 and alcohols leading to vinyl phosphorodithioates has been developed under mild conditions.
A catalyst-free cross-coupling of isocyanates and triarylboranes for secondary amide synthesis
Authors: Wu You-Wei , Chen Mu-Xiang , Li Yan , Hu Lu-Min , Zhao Lili , Jia Zhenhua , Zhao Xuefei , Hu Xu-Hong
Published: November 2023

A distinct protocol for secondary amide formation through a catalyst- and additive-free cross-coupling of isocyanates with triarylboranes has been described.
Bio-functionalized nanocolloids of ZnS quantum dot/amine-rich polypeptides for bioimaging cancer cells with antibacterial activity: “seeing is believing”
Authors: Mansur Alexandra A. P. , Carvalho Sandhra C. , Dorneles Elaine M. S. , Lage Andrey P. , Lobato Zelia I. P. , Mansur Herman S.
Published: November 2023

Nanotechnology meets oncology: peptide-functionalized nanohybrids for bioimaging cancer cells and antibacterial activity.
Cancer cell membrane fused liposomal platinum(iv) prodrugs overcome cisplatin resistance in esophageal squamous cell carcinoma chemotherapy
Authors: Zhang Shuaibing , Jiang Wei , Wang Shenghui , Song Kexu , Ge Mengyue , Zhang Lirong , Yan Xiyun , Jiang Bing
Published: November 2023

EMLipoPt(iv) was designed to combat cisplatin resistance in esophageal squamous cell carcinoma (ESCC) by enhancing platinum uptake and minimizing drug inactivation through a fusion of ESCC cell membrane with liposomal Pt(iv) prodrugs.
Event‐triggered delayed impulsive control for quasi‐synchronization of complex dynamic systems with packet loss and parameter mismatch
Authors: Li Heng , Li Liangliang , Jiang Wenlin
Published: November 2023

This paper studies the event triggered delayed impulsive control strategy for quasi‐synchronization for complex dynamical systems with parameter mismatch and packet loss. By constructing a comparative lemma with time delays and Lyapunov function, a few sufficient synchronization conditions are proposed by Cauchy matrix with time delays to analyze the system. Meanwhile, the possibility of packet loss is also considered and the quasi‐synchronization of the system is investigated by using both event triggered delayed impulsive control and self‐triggered impulsive control mechanisms. Theoretical analysis results are validated by numerical simulations.
The effect of visibility on road traffic during foggy weather conditions
Authors: Ali Faryal , Khan Zawar Hussain , Khattak Khurram Shehzad , Gulliver Thomas Aaron
Published: November 2023

The impact of fog on visibility is a major factor affecting traffic congestion and safety. This paper proposes a microscopic traffic model that captures the features of traffic in foggy weather and characterizes it based on visibility. The intelligent driver (ID) model is based on a constant acceleration exponent and produces similar traffic behaviour for all conditions, which is unrealistic. The performance of the ID and proposed models is evaluated on a 2.2 km ring road for 250 s with a platoon of 51 vehicles. Results are presented which show that the proposed model characterizes traffic realistically with lower acceleration and deceleration compared to the ID model. Further, it does not create stop‐and‐go waves and is stable even during foggy weather. The proposed model can be used to reduce fuel consumption and pollution resulting from traffic congestion.
Protoplanetary and debris disks in the η Chamaeleontis Association
Authors: Roccatagliata V. , Sicilia-Aguilar A. , Kim M. , Campbell-White J. , Fang M. , Murphy S. J. , Wolf S. , Lawson W. A. , Henning Th. , Bouwman J.
Published: November 2023

Context. Nearby associations are ideal regions to study coeval samples of protoplanetary and debris disks down to late M-type stars. Those aged 5–10 Myr, where most of the disk should have already dissipated forming planets, are of particular interest.

Aims. We present the first complete study of both protoplanetary and debris disks in a young region, using the η Chamaeleontis (η Cha) association as a test bench to study the cold disk content. We obtained submillimeter data for the entire core population down to late M-type stars, plus a few halo members.

Methods. We performed a continuum submillimeter survey with APEX/LABOCA of all the core populations of the η Cha association. These data were combined with archival multiwavelength photometry to compile a complete spectral energy distribution. The disk properties were derived by modeling protoplanetary and debris disks using RADMC 2D and DMS, respectively. We compute a lower limit of the disk millimeter fraction, which is then compared to the corresponding disk fraction in the infrared for η Cha. We also revisit and refine the age estimate for the region, using the Gaia eDR3 astrometry and photometry for the core sources.

Results. We find that protoplanetary disks in η Cha typically have holes with radii on the order of 0.01–0.03 AU, while ring-like emission from the debris disks is located between 20 and 650 au from the central star. The parallaxes and Gaia eDR3 photometry, in combination with the PARSEC and COLIBRI isochrones, enable us to confirm an age of η Cha between 7 and 9 Myr. In general, the disk mass seems insufficient to support accretion over a long time, even for the lowest mass accretors, a clear difference with other regions and also a sign that the mass budget is further underestimated. We do not find a correlation between the stellar masses, accretion rates, and disk masses, although this could be due to sample issues (very few, mostly low-mass objects). We confirm that the presence of inner holes is not enough to stop accretion unless accompanied by dramatic changes to the total disk mass content. Comparing η Cha with other regions at different ages, we find that the physical processes responsible for debris disks (e.g., dust growth, dust trapping) efficiently act in less than 5 Myr.
Multiphase characterization of AGN winds in five local type-2 quasars
Authors: Speranza G. , Ramos Almeida C. , Acosta-Pulido J. A. , Audibert A. , Holden L. R. , Tadhunter C. N. , Lapi A. , González-Martín O. , Brusa M. , López I. E. , Musiimenta B. , Shankar F.
Published: November 2023

We present MEGARA integral field unit (IFU) observations of five local type-2 quasars (QSO2s, z ∼ 0.1) from the Quasar Feedback (QSOFEED) sample. These active galactic nuclei (AGN) have bolometric luminosities of 1045.5 − 46 erg s−1 and stellar masses of ∼1011 M⊙. The LR-V grating of MEGARA allows us to explore the kinematics of the ionized gas through the [O III]λ5007 Å emission line. The nuclear spectra of the five QSO2s, extracted in a circular aperture of ∼1.2″ (∼2.2 kpc) in diameter, matching the resolution of these seeing-limited observations, show signatures of high velocity winds in the form of broad (full width at half maximum, 1300 ≤ FWHM ≤ 2240 km s−1) and blueshifted components. We found that four out of the five QSO2s present outflows that we can resolve with our seeing-limited data, and they have radii ranging from 3.1 to 12.6 kpc. In the case of the two QSO2s with extended radio emission, we found that it is well aligned with the outflows, suggesting that low-power jets might be compressing and accelerating the ionized gas in these radio-quiet QSO2s. In the four QSO2s with spatially resolved outflows, we measured ionized mass outflow rates of 3.3–6.5 M⊙ yr−1 when we used [S II]-based densities, and of 0.7–1.6 M⊙ yr−1 when trans-auroral line-based densities were considered instead. We compared them with the corresponding molecular mass outflow rates (8–16 M⊙ yr−1), derived from CO(2–1) ALMA observations at 0.2″ resolution. The cold molecular outflows carry more mass than their ionized counterparts. However, both phases show lower outflow mass rates than those expected from observational scaling relations where uniform assumptions on the outflow properties were adopted. This might be indicating that the AGN luminosity is not the only driver of massive outflows and/or that these relations need to be rescaled using accurate outflow properties (i.e., electron density and radius). We did not find a significant impact of the outflows on the global star formation rates when considering the energy budget of the molecular and ionized outflows together. However, spatially resolved measurements of recent star formation in these targets are needed in order to evaluate this fairly, considering the dynamical timescales of the outflows, of 3–20 Myr for the ionized gas and 1–10 Myr for the molecular gas.
The SOPHIE search for northern extrasolar planets
Authors: Heidari N. , Boisse I. , Hara N. C. , Wilson T. G. , Kiefer F. , Hébrard G. , Philipot F. , Hoyer S. , Stassun K. G. , Henry G. W. , Santos N. C. , Acuña L. , Almasian D. , Arnold L. , Astudillo-Defru N. , Attia M. , Bonfils X. , Bouchy F. , Bourrier V. , Collet B. , Cortés-Zuleta P. , Carmona A. , Delfosse X. , Dalal S. , Deleuil M. , Demangeon O. D. S. , Díaz R. F. , Dumusque X. , Ehrenreich D. , Forveille T. , Hobson M. J. , Jenkins J. S. , Jenkins J. M. , Lagrange A. M. , Latham D. W. , Larue P. , Liu J. , Moutou C. , Mignon L. , Osborn H. P. , Pepe F. , Rapetti D. , Rodrigues J. , Santerne A. , Segransan D. , Shporer A. , Sulis S. , Torres G. , Udry S. , Vakili F. , Vanderburg A. , Venot O. , Vivien H. G. , Vines J. I.
Published: November 2023

Transiting planets with orbital periods longer than 40 d are extremely rare among the 5000+ planets discovered so far. The lack of discoveries of this population poses a challenge to research into planetary demographics, formation, and evolution. Here, we present the detection and characterization of HD 88986 b, a potentially transiting sub-Neptune, possessing the longest orbital period among known transiting small planets (<4 R⊕) with a precise mass measurement (σM/M > 25%). Additionally, we identified the presence of a massive companion in a wider orbit around HD 88986. To validate this discovery, we used a combination of more than 25 yr of extensive radial velocity (RV) measurements (441 SOPHIE data points, 31 ELODIE data points, and 34 HIRES data points), Gaia DR3 data, 21 yr of photometric observations with the automatic photoelectric telescope (APT), two sectors of TESS data, and a 7-day observation of CHEOPS. Our analysis reveals that HD 88986 b, based on two potential single transits on sector 21 and sector 48 which are both consistent with the predicted transit time from the RV model, is potentially transiting. The joint analysis of RV and photometric data show that HD 88986 b has a radius of 2.49 ± 0.18 R⊕, a mass of 17.2−3.8+4.0 M⊕, and it orbits every 146.05−0.40+0.43 d around a subgiant HD 88986 which is one of the closest and brightest exoplanet host stars (G2Vtype, R = 1.543 ± 0.065 R⊙, V = 6.47 ± 0.01 mag, distance = 33.37 ± 0.04 pc). The nature of the outer, massive companion is still to be confirmed; a joint analysis of RVs, HIPPARCOS, and Gaia astrometric data shows that with a 3σ confidence interval, its semi-major axis is between 16.7 and 38.8 au and its mass is between 68 and 284 MJup. HD 88986 b’s wide orbit suggests the planet did not undergo significant mass loss due to extreme-ultraviolet radiation from its host star. Therefore, it probably maintained its primordial composition, allowing us to probe its formation scenario. Furthermore, the cold nature of HD 88986 b (460 ± 8 K), thanks to its long orbital period, will open up exciting opportunities for future studies of cold atmosphere composition characterization. Moreover, the existence of a massive companion alongside HD 88986 b makes this system an interesting case study for understanding planetary formation and evolution.
Acquired heart defects: Clinical picture, diagnosis
Authors: Totrov Igor , Ulubieva Elena , Isaeva Elina
Published: November 2023

In acquired heart defects, they are defined as the occurrence of an irreversible violation in its structure, that leads to a complete loss of its function, changes in intracardiac hemodynamics, as well as change in intracardiac hemodynamics, as a result of which there is an overload of the corresponding parts of the heart, hypertrophy and dilatation of the chambers and circulatory disorders throughout the body. The main causes of valvular heart disease formation: the hereditary connective tissue disorder (mitral valve prolapse, leading to severe mitral insuficience) and other connection tissue disorders (mitral valve prolapse leads to severa mitral insufficiency) • infectious or rheumatic endocarditis.
Compensation for iodine deficiency conditions with drugs based on duckweed substrate
Authors: Sadulaev M. Kh. , Usmanova M. I. , Tataev T. T. , Inderbiev A. M. , Zhamalullayla A. S.-A.
Published: November 2023

Currently, one of the important problems for the entire population of Russia is the problem of iodine deficiency. This pathology is of significant relevance for residents of the North Caucasus. The growth of the goiter epidemic was provoked by the abolition of iodine prophylaxis from salt iodization in the 70s of the 20th century. In order to avoid an increase in morbidity, they began to develop and introduce not only iodine-containing preparations of chemical origin, but also medicines developed from iodine-containing plants acquired particular relevance. Iodine found in plants is well absorbed by the human body, as it is close to it in biological structure. The most common and generally accepted medicinal plants for the treatment of iodine deficiency conditions are white cinquefoil, sugar kelp and bladderwrack. These plants have a high content of natural iodine, but at the same time, the problem is a significant limitation of raw materials. That is why the search for new plant substrates with a high iodine content and the possibility of restoring iodine deficiency states is so important.
Promising technologies of intellectual agriculture
Authors: Khatmat Abuevn Matagova
Published: November 2023

The future workforce of agricultural enterprises will be mainly engaged in warehousing activities. Therefore, it is important to create an environment conducive to the intellectual growth of young people, which is often caused by crime. The article discusses the expected prerequisites for digitalization and the development of a “smart developed economy” and shows practical progress in agrarian relations. However, priority should be given to human resources for economic development. Modern times require a well-developed system of personnel retraining, organizing the labor discipline of residents engaged in small-scale economic activities, and exploring alternative forms of productive participation within the population. Promising smart agriculture technologies are expected to provide effective and environmentally sustainable pest management, support soil and groundwater restoration and conservation, and ensure continuous monitoring of compliance with organic agriculture certification requirements. An emerging agricultural workforce that is properly trained and equipped with the latest information technologies for smart agriculture plays an important role in the development of modern agriculture. Therefore, a key objective of agricultural sector personnel policies should be to carefully select a highly skilled workforce, nurture human potential, and increase production efficiency through digitization and modernization of all individual agricultural enterprises.
Sanitary-toxicological assessment of drinking water quality in the city of Grozny
Authors: Ataeva Aminat , Muzakaeva Khava , Shepiev Lom-Ali
Published: November 2023

The article presents the data of sanitary-toxicological studies on the assessment in a comparative aspect of toxicity and cumulative properties of drinking water from different places of water intake in the city of Grozny before and after water treatment. An assessment is made of the influence of drinking water quality on the health of experimental animals in a chronic sanitary-toxicological experi-ment.
Principles for protecting the natural diversity of insects at the regional level
Authors: Cherchesova Susanna , Maltsagov Isa
Published: November 2023

Insects play a key role in the biodiversity of regional ecosystems. To effectively protect natural diversity at the regional level, it is important to adhere to certain principles. This article discusses the basic principles of protecting the natural diversity of insects at the regional level. These principles include an ecosystem-based approach, conservation of multiple habitats, protection of endemic species, mitigation of human impacts, Red List species assessment, public engagement, biodiversity research, sustainable land use, collaboration and partnerships, and adaptation to changing conditions. Compliance with these principles contributes to the conservation of insect biodiversity and promotes the health of regional ecosystems.
Analysis of key success factors of Russian biotech firms
Authors: Musaeva Kheda
Published: November 2023

A protracted production cycle that demands substantial resources is faced by Biotechnology companies, which face a long-term production cycle that demands large financial resources. During economic crises in Russia, particularly in biotechnology, there is a significant decline in market demand. During the economic crisis in Russia, as well as in sectors like biotechnology, there is a significant decline in market demand. It is this situation that intensifies competition among existing biotech firms, not only in marketing the products but also in securing capital resources for business development. As to ensure the success and longevity of biotechnology companies, it is imperative that you devise effective management strategies. A company’s success and competitiveness is assessed by comparing its strengths and weaknesses with its industry peers. In order to achieve the exceptional performance of a specific enterprise or the industry as a whole, strategic requirements should be aligned with strategic goals. The biotech firms can solidify or maintain their position for some time. This is the reason for biotech firms to solidify or maintain their positions for a certain duration. The concept of competitive advantage in this context is defined by R. Grant, as defined by R. Grant: the process of competition with two companies, where one has a competitive edge that leads to the potential for higher profitability.
Development of bioeconomy in an innovative society
Authors: Guzueva Elina , Magomaev Tamirlan , Adymkhanov Askhab
Published: November 2023

Scientists identify several fundamental drivers behind the advancement of the bioeconomy. These include the challenges of global food shortages due to population growth, the finite nature of minerals and energy resources, concerns about environmental pollution, the rapid progression of space exploration, the transformative influence of the Fourth Industrial Revolution and quantum computing on human behavior and societal structures, the evolution of science with a particular emphasis on the swift growth of biotechnology, the emergence of nanotechnology and nanomedicine, and the rapid pace of technological development within the context of singularity. These factors collectively contribute to an enhanced quality of life and extended life expectancy. Presently, a consensus among most academic economists is that the foremost factor driving economic growth and the development of modern nations is knowledge. It is widely believed that countries that actively harness new knowledge, effectively becoming knowledge-intensive, will be well-positioned for economic development between 2030 and 2050.
“Green” infrastructure as a factor in ensuring sustainable urban development
Authors: Musaeva Kheda
Published: November 2023

At present, the sustainable development of city is an actual and most dynamically developing trend in management systems as well as functioning of megacities. The concept “sustainable development” is one of the most important and most dynamically developing tendencies in managed systems for all kinds of cities, primarily megacities. Aims to improve the quality of life, creating comfortable living conditions for citizens and attract investments in urban development through preservation of ecosystems. The development is aimed at improving the quality of life, creating comfortable living conditions for the population and attracting investment in the urban economy through the preservation of ecosystems and the development of “green” infrastructure. A sustainable development is an example of the kinds of economic activity, in that it has been considered as such development. In this way there are different interests from different groups of people whose interests have come together to achieve its goal: protecting the environment and business sector with social space; at the same time creating balance for three main interests of life: economic, sociocultural and environmental. It is worth noting that the concept of sustainable development, in addition to obtaining economic preferences, makes it possible to reduce conflict situations in the city and provide social stability.
Human capital at different stages of socio-economic development
Authors: Dasuev Izruddin
Published: November 2023

The provided article represents an advancement of research focused on evaluating human capital concerning structural transformations within the economy. The primary aim of this study is to establish the link between the development of human capital and the structural shifts within the global economy. This is accomplished by integrating diverse multidisciplinary approaches for assessing human capital and forming a set of parameters to gauge the status of a nation's human capital within the framework of current and evolving world economic and technological structures. To fulfill this objective, the following tasks were addressed: identifying key classification features that delineate the characteristics of human capital development and utilization across various technological and global economic structures; constructing a comprehensive matrix of parameters that determine the condition of human capital within global economic and technological frameworks; and exploring how the processes of human capital formation are reflected in strategic plans for national economic development.
The contribution of companies’ ESG transformation to global sustainability
Authors: Musaeva Bela
Published: November 2023

GHG emissions anywhere in the world affect the global atmosphere. Thus, the deterioration of the emissions situation in one region is not a regional but a global problem. Most developed countries have already announced ambitious goals in the field of green energy, in particular, they supported the transition to electric vehicles. The ongoing geopolitical transformation has accelerated these efforts and prompted many governments to intensify them to further reduce dependence on Russian oil and gas and hydrocarbons in general. However, the accelerated energy transition raises issues related, in particular, to the life cycle, processing and disposal of equipment involved in energy transformation, renewable energy, and electric vehicles. Over the years, the problem of the impact of business on the environment has become increasingly popular and relevant. As the consequences of environmental neglect become more and more evident over time, it is important for all stakeholders to some extent to see a green transformation of operations and supply chains (SCs).
Import substitution as an instrument of socio-economic development on the example of the Chechen Republic
Authors: Basnukaev Musa , Tataev Yusup , Gaziev Magomed
Published: November 2023

In recent years, the Russian Federation and its constituent regions have experienced serious difficulties associated with the introduction of international sanctions. International economic sanctions have different mechanisms and structures - they affect the export of high-tech equipment, the ability to attract external borrowing, the functioning of digital services and other aspects of the activities of commercial enterprises. The key tool to counter these challenges is import substitution, which allows reducing dependence on external supplies and ensuring more stable development in conditions of economic uncertainty. Import substitution stimulates the development of national production and the creation of new jobs, which in turn can help improve the economic situation in Russia. This article examines the theoretical foundations of the policy of import substitution, analyzes strategies and plans for import substitution at the present stage, and also characterizes import substitution as a tool of socio-economic development using the example of the Chechen Republic.
Reducing emissions during the formation of intelligent transport and logistics systems in the city
Authors: Savin Gleb , Savina Valeria
Published: November 2023

Nowadays transport is becoming one of the main sources of pollution in the city. In this area, the development of intelligent transport and logistics systems (TLS) and the use of advanced digital technologies makes it possible to reduce harmful emissions and improve the standard of living in modern megacities. The development of these systems is considered as an optimal approach to the use of investments and resource. Within the framework of Technical Committee 204, cross-country research cooperation is being implemented in the field of architecture, automatic vehicle identification, freight cart management, standards for cooperative intelligent transport systems and adaptive traffic management systems are being tested to increase the level of mobility and environmental friendliness in the city.
Acceleration of the digital economy as support for sustainable development
Authors: Kuhnová Lenka , Szaryszová Petra , Bosák Martin
Published: November 2023

Leading companies are increasingly using digital technologies to transform their business models with the aim of better solution of social challenges. However, there is not enough management data on whether it is a positive driver influencing innovation for both the economy and society. Research on the digital economy continues to develop but is limited to one country or area. From a bibliometric retrospective review, the paper deals with the current discussion on the alignment between sustainability challenges and innovation procedures based on the digitization of the economy. This study used bibliometric techniques using the VOSViewer program and the search results analysis function of the Springer database. This study analyzed 40,932 scientific documents published from 1841 to 2023. We further investigated the support of digital transformation and sustainability in EU countries by beta convergence and PCA analysis. The results confirm the convergence of EU countries and progress in the implementation of digital technologies in the field of digital transformation of sustainable development. The EU actively supports digital transformation and the Digital Single Market through various initiatives and policies.
Biotechnology: Socio-economic, political and ethical aspects
Authors: Nataeva Zalina , Dzhatdoeva Diana , Zakalyukina Elena
Published: November 2023

The experiences of the past century have led to the realization that technological innovations often proceed without adequate testing for their readiness and potential consequences for humanity. The prevailing mindset often revolves around the stereotypes of continuous scientific and technological progress, where new developments are rapidly integrated into consumer society, including military applications, without comprehensive oversight. These waves typically encompass several decades and are associated with the evolution of technologies and industries. They provide a framework for understanding how technological innovations and economic structures interact and evolve over time. The concern raised is that during these waves of technological and economic development, there may not always be sufficient consideration of the potential consequences, both positive and negative, of the innovations introduced. This lack of foresight can result in unforeseen challenges and risks for society. In today's rapidly changing technological landscape, it is crucial to consider the ethical, environmental, and societal implications of emerging technologies. A more cautious and responsible approach to technological progress, taking into account the broader implications for humanity, is increasingly important to ensure the well-being and sustainability of our global society.
Development of new resource-saving, environmentally friendly technological processes in flour grinding production
Authors: Lesnikova Natalia , Pankratieva Natalia , Goncharova Nadezhda
Published: November 2023

The gist of this article boils down to methods for processing secondary raw materials in flour milling. Methods for separating the wheat germ in both the grain cleaning and grinding departments have been studied. A method has been proposed for obtaining wheat germ using a beaker with subsequent pneumatic separation of passing products. To grind wheat germ to a finely dispersed composition with a solid particle size of less than 100 microns, a dry mechanical activation method using a disintegrator is provided. The chemical and amino acid composition of the resulting wheat germ flour was studied. The homogeneous fine composition of wheat germ flour made it possible to use it in the production of bakery products without deteriorating their quality. The developed technology for processing wheat germ is resource saving, environmentally friendly and allows you to preserve completely all biologically valuable substances present in the by-products of wheat processing.
Identifying consumers of pharmaceutical products and developing their sustainable loyalty
Authors: Shchekoldin Vladislav , Tsoy Marina , Shevtsov Vladislav
Published: November 2023

This research addresses a critical issue in the pharmaceutical industry – identifying loyal and consistent customers. Factors such as the need for stable product demand, reduced marketing expenditures, and expanding customer base underscore the significance of this task. Effective pharmaceutical enterprise management hinges on the accurate identification and retention of steadfast customers. The study highlights the complexities within the sector, necessitating targeted customer analysis approaches. It emphasizes the importance of tailored, innovative methods considering the industry's unique regulatory constraints and characteristics. Factor analysis of customer attributes revealed homogenous groups, leading to the development of strategies to enhance interactions and secure the company's market position.