bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting results of idiopathic macular hole surgery
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation, Boriskina L.N. , Solodkova E.G. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation, Zotov A.S. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation, Balalin A.S. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation, Purshak S.M. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation, Melikhova I.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation, Balalin S.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation, Maruchenko A.M. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation, Efremova T.G. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Volgograd branch, Volgograd, Russian  Federation
Published: May 2022

There are some works on predicting the functional results in patients with idiopathic macular holes (IMH). Purpose. To estimate the role of microperimetry and optical coherence tomography in predicting the results of the idiopathic macular holes surgical treatment. Material and methods. A retrospective analysis of the treatment results of 51 patients with IMH (51 eyes) aged from 52 to 77 years was carried out. Patients were classified into 3 groups depending on the IMH size: small (up to 250 μm) – 15 patients (15 eyes); medium (250-400 μm) – 16 patients (16 eyes) and large (over 40 μm) – 20 patients (20 eyes). The follow-up period was 6 months. Results. To determine the predicted visual acuity, we used a formula for the dependence of BCVA post-op on the retinal photosensitivity and the minimum IMH diameter pre-op: Z = 0,1227 – 0,0002 × X + 0,0099 × Y, where Z is the BCVA post-op, X is the minimum IMH diameter pre-op (μm), Y is the retinal photosensitivity pre-op (dB). After surgical treatment: 1st patients’ group had a significant improvement of BCVA by 0.28 ± 0.06, retinal photosensitivity – by 5.1 ± 1.3 dB, predicted BCVA was 0.38 ± 0.041; in the 2nd group BCVA improved by 0.17 ± 0.06, retinal photosensitivity – by 4.8 ± 2.6 dB, predicted BCVA was 0.23 ± 0.047; in the 3rd group BCVA improved by 0.07 ± 0.07, retinal photosensitivity by 2.5 ± 1.2 dB, predicted BCVA was 0.17 ± 0.06. Conclusion. The formula derived on the basis of these examinations can be successfully applied to predict functional outcome before surgical treatment. Keywords: idiopathic macular hole, microperimetry, vitrectomy, optical coherence tomography.
Results of surgical treatment of recurrent macular holes
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Zhigulin A.V.
Published: May 2022

Purpose. Analysis of the functional and anatomical results of surgical treatment of recurrent idiopathic macular holes (IMH) using the method of approaching the edges of the gap and repeated silicone tamponade. Material and methods. The results of surgical treatment of 8 patients (8 eyes) with recurrent IMH were analyzed. In all patients, it corresponded to stages 3–4. The duration of the disease varied from 6 months to 1 year. In all cases of IMH relapses, repeated surgical treatment was performed 1 month after the primary operation. The silicone was removed and the edges of the rupture were again brought together by passive aspiration followed by tamponade with silicone 5700. The silicone was removed 1–2 months after repeated surgical treatment. Results. After repeated surgical treatment, in 7 out of 8 cases, complete closure of the macular hole was noted on the first day. In one case, the gap did not close and the disease was combined with age-related macular degeneration. In 7 cases, a positive functional result was achieved in the form of an increase in visual acuity up to 0.15 ± 0.14. In one patient, visual acuity remained unchanged. Conclusion. Thus, the re-approach of the edges of the macular hole followed by silicone tamponade in the treatment of recurrent IMH made it possible to achieve complete closure of the hole in 7 out of 8 patients, which was 87 %. Keywords: macular rupture, vitrectomy, method of approaching the edges of the rupture, repeated silicone tamponade, visometry indices, optical coherence tomography.
Vascular retinal pathology: effect of gestational hypertension and preeclampsia on its formation
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Kolenko O.V. ,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Far Eastern State Medical University, Khabarovsk, Russian Federation, Fil A.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation
Published: May 2022

Purpose. To assess the effect of gestational arterial hypertension (AH) and preeclampsia on the possible development of vascular retinal pathology in the separated postpartum period. Material and methods. 231 women with different types of pregnancy. 1st main group – pregnant women with gestational hypertension. 2nd main group – pregnant women with preeclampsia. 1st comparison group: pregnancy with chronic hypertension without proteinuria. 2nd comparison group: edema and / or proteinuria during pregnancy, but without hypertension. Control group – physiological pregnancy. The term of an ophthalmological examination after pregnancy is 6–12 years. Results. Over the past time period after childbirth, 67 women in the total population were found to have systemic vascular pathology (29 %). The formation of vascular retinal pathology for the period after childbirth occurred in 50 women in the general population (21.6 %). Conclusion. The incidence of vascular retinal pathology in the late postpartum period (up to 12 years) was statistically significantly higher in the groups with preeclampsia (48 %) and gestational hypertension (40 %) in comparison with the physiological course of pregnancy, as well as in pregnancy accompanied by edema without AH and with the presence of AH before pregnancy (4, 6 and 8 %, respectively, p < 0.01). Keywords: systemic vascular pathology, retinal vascular pathology, hypertensive disorders during pregnancy, endothelial dysfunction.
Clinical case of occlusion of branch of central retinal vein in patient with history of COVID-19
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch,  Khabarovsk, Russian Federation, Romanova A.V. , Burya R.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch,  Khabarovsk, Russian Federation, Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch,  Khabarovsk, Russian Federation,   Far Eastern State Medical University, Khabarovsk, Russian Federation
Published: May 2022

The article presents a clinical case of the formation of occlusion of a branch of the central retinal vein (CRV) in a patient who had a coronavirus infection (COVID-19). The data of an ophthalmological examination, as well as the tactics of further management of the patient, are demonstrated. Substantiates the assumption that the occlusion of the CRV branch is related to the previously brought COVID-19. Keywords: occlusion of the central retinal vein, COVID-19, new coronavirus infection, clinical case, ophthalmopathology.
Medical work in 2021 of the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution. Results and prospects
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Kolenko O.V. ,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Pshenichnov M.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation
Published: May 2022

The results of medical work of the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution in 2021 on rendering of specialized, including hitech, ophthalmological care for diseases of the eye and adnexa to patients of the Far Eastern Federal District were summed. Keywords: ophthalmology, specialized medical care, high-tech medical care, emergency eye care, Far Eastern Federal District.
Clinical experience of combined use of the angiogenesis inhibitor aflibercept in the treatment of retinal vein occlusions
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation, Zhaivoronok N.S. , Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk , Russian Federation, Smoliakova G.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk , Russian Federation, Danilova L.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk , Russian Federation, Emanova L.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation, Povalyaeva D.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation, Udovichenko E.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk , Russian Federation
Published: May 2022

Purpose. To evaluate the effectiveness of the combined use of aflibercept and sulodexide in the treatment of macular edema (ME) in retinal vein occlusions (RVO). Material and methods. In the course of the study, 30 patients with MO with acute respiratory infections not exceeding 1.5 months ago were monitored. All underwent a standard ophthalmological examination, as well as optical coherence tomography with angiography function and electrophysiological studies. To assess the effectiveness of the combined use of aflibercept and sulodexide, all patients were divided into two groups. In patients of the first group (n = 16), the first intravitreal injection of aflibercept was supplemented with a course of sulodexide. The second group (n = 14) did not receive sulodexide. Results. The degree of improvement in the functions of the eye in patients of the first group, who received sulodexide in complex treatment, is due to the maximum level of restoration of retinal microcirculation in the macula due to an increase in the density of the capillary network in the superficial and deep vascular plexuses of the retina by more than 1.2 times and a decrease in the area of its foveal avascular zone 1.5 times in comparison with the initial state. Conclusion. The results of the study showed the high efficiency of the combined use of aflibercept and sulodexide in the treatment of MO in acute respiratory infections and allow us to recommend their use to improve hemomicrocirculation in the macular retina and increase visual functions. Keywords: macular edema, retinal vein occlusion, aflibercept, sulodexide.
Complex surgical reconstruction of the ocular surface, eyelids, lacrimal ducts and orbit after severe combined injury (clinical case)
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Banshchikov P.A. , Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Smoliakova G.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation
Published: May 2022

The article presents clinical case of severe combined injury ocular surface, ocular adnexa, lacrimal duct, orbital walls. The article describes a staged complex surgical rehabilitation, performed in the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution: of orbital walls with “Ekoflon” material (Russia), of lacrimal duct by Taumi method, of medial palpebral ligament, of upper eyelid coloboma with free skin graft; locomotory stump and ocular cosmetic prosthesis after evisceration. In the long-term period (14 months), restoration of the eyelids anatomy, the measures of the palpebral fissure, the mobility of the upper eyelid, positive function of lacrimation, normal positioning and good eye prosthesis movement was noted. Keywords: combined ocular injury, reconstructive and cosmetic eyelid surgery, lacrimal duct reconstruction; periorbital reconstruction; eye prosthesis.
Benefits of local anesthetic Levobupivacaine in ambulatory endovitreal surgery
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation, Bachinin E.A. , Utkin S.I. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation, Ignatenko D.Y. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation, Stolyarov M.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation, Khalfin R.N. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation
Published: May 2022

Purpose. Comparative analysis of local anesthetics for retrobulbar block in outpatient endovitreal interventions. Material and methods. The study included 30 patients who underwent combined anesthesia: local (regional) and ataralgesia during outpatient endovitreal operations. Local anesthesia was performed in form of retrobulbar block in the muscle cone delineating the retrobulbar space with introduction of 3.0 ml of local anesthetic. Ataralgesia included benzodiazepines and intravenous fentanyl. According to the type of anesthetic, 2 groups of patients were identified: 1st group – 15 patients who received 2% lidocaine solution; 2nd group – 15 patients – 0.75% solution of levobupivacaine. Results. In all 2 groups, a sufficient level of anesthesia was achieved, which made it possible to perform surgical interventions as planned, without complications. The average duration of operation in each group was 15–20 minutes. Stable course of operation, anesthesia and early postoperative period were allowed patient to be discharged for further treatment at place of residence on day of operation. Conclusion. In all patients, the applied method of combining regional anesthesia with ataralgesia made it possible to achieve an excellent level of pain relief and turned out to be approximately comparable in efficiency with both levobupivacaine and lidocaine. The advantage of using levobupivacaine for regional anesthesia was greater strength and duration of anesthesia. The technique was characterized by development of pronounced neurovegetative blockade and protection from surgical stress response, early activation of patients and ability to discharge patient for further treatment at place of residence on day of surgery. Keywords: endovitreal interventions, outpatient surgery, regional anesthesia, ataralgesia, levobupivacaine, lidocaine.
Strategy of an ophthalmologist in assessing the possibilities of delivery in healthy pregnant women with myopic refraction
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation, Kolenko O.V. ,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation,   Far Eastern State Medical University, Khabarovsk, Russian Federation, Fil A.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation
Published: May 2022

The review highlights aspects of the evolution of the views and opinions of ophthalmologists of different years on ophthalmological and obstetric approaches to the management of pregnancy and childbirth in women with high myopia. According to the literature, prevention of the risk of regmatogenic retinal detachment during childbirth since the early 1980s of the last century has been aimed at identifying peripheral vitreochorioretinal dystrophy during pregnancy as the leading risk factor for regmatogenic retinal detachment during childbirth. The main modern strategies for the management of pregnant women with the presence of peripheral vitreochorioretinal dystrophy during pregnancy and childbirth are considered; indications for natural delivery with high-grade myopia, absolute and relative indications for its implementation in a natural way are presented. This is reflected in the specific selection criteria for natural delivery. Keywords: pregnancy, natural delivery, cesarean section, peripheral vitreochorioretinal dystrophy, regmatogenic retinal detachment, high-grade myopia.
Questioning as an independent assessment of the quality of services in a specialized ophthalmological clinic
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation, Savchenko N.V. , Baleva O.B. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation, Egorov V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian  Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation
Published: May 2022

The article presents an analysis of the survey data, which made it possible to study the dynamics of the evaluation of the opinions of 460 patients of the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution (Branch) in 2018, 2019 and 2021. The questions formulated in the questionnaire concerned the respondents’ satisfaction with the work of medical and auxiliary departments, as well as interpersonal relations “medical worker – patient”. As a result, it was revealed that patient satisfaction with the work of all structures of the Branch was higher in 2021 than in 2018 and 2019. Negative feedback about the work of coordination (the inability to get through) remained the same, but for a smaller number of people (satisfaction with the work of coordination was 94% in 2018, in 2021 – 99%). The measures taken by the Administration based on the results of previous questionnaire surveys have led to an improvement in the quality of medical care in the Branch. Questioning is an effective method of independent assessment of the quality of medical care. Keywords: questioning, respondent, quality of medical care.
Clinical case of formation of iatrogenic ectasia after excimer surgery using PRK technology
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian Federation, Shishkin S.A. , Dutchin I.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian Federation, Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch, Khabarovsk, Russian Federation,   Far Eastern State Medical University, Khabarovsk, Russian Federation
Published: May 2022

The article analyzes a clinical case of the formation of secondary keratectasia after photorefractive keratectomy in the correction of high myopia. Preoperative diagnosis of such conditions is extremely difficult, and there is always the possibility of keratectasia in the postoperative period, despite the entire volume of diagnostic studies and various surgical techniques. Keywords: myopia, refractive surgery, keratectasia, biomechanical properties of the cornea, pachymetric index.
Assessment of immediate results of implantation of a phakic IOL of the Visian Implantable Collamer Lens (Visian ICL) model in a patient with a combination of high myopia and a clinically thin cornea
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Belonozhenko Y.V. , Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation
Published: May 2022

The article evaluates the clinical effectiveness of implantation of a phakic intraocular lens model (IOL) Visian ICL in a patient with a combination of high myopia and clinically thin cornea on the example of a clinical case. Implantation of a personalized posterior chamber phakic IOL is a clinically effective, safe and predictable method for the surgical correction of high myopia, including in patients with clinically thin corneas, when keratorefractive intervention is contraindicated. Keywords: myopia, phakic IOL IPCLV 2.0, intraoperative difficulties.
First experience of the RayOne Trifocal intraocular lens implantation
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Krivko S.V. , Belonozhenko Y.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation, Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation,   Far Eastern State Medical University, Khabarovsk, Russian Federation, Semenova T.K. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk branch,  Khabarovsk, Russian Federation
Published: May 2022

Purpose. To study refractive result of the RayOne Trifocal intraocular lens (IOL) implantation (Rayner, UK). Material and methods. 32 patients (32 eyes) were selected for the RayOne Trifocal IOL implantation. All patients underwent standard preoperative ophthalmological examination. The IOL diopters were calculated using ZEISS IOL Master 700 (Carl Zeiss, Germany). In postoperative period, the achievement of target refraction (emmetropia) was assessed using autorefractor keratometry (Tomey Corp., Japan), as well as visometry for distance, at an intermediate distance (70 cm), and for near. Results. In vast majority of cases (22 eyes, 68 %), postoperative spherical equivalent within ±0.5 diopters (target refraction) was obtained; in 9 eyes (28 %) – weak myopic spherical equivalent, in one case – weak hyperopic equivalent. On the 1st day of postoperative period, uncorrected visual acuity for distance in vast majority of cases (22 eyes, 68 %) was 0.8–1.0, in 5 eyes (16 %) it was 0.5–0.7; in 5 eyes – 0.1–0.4 (16 %). The best corrected visual acuity in 12 eyes (38 %) was 0.7–0.8. At a distance of 70 cm, high visual acuity (0.8–1.0) was achieved in 26 eyes (81 %), 0.6 – in 6 eyes (19 %). Visual acuity for near vision without correction for most patients (28 eyes, 87 %) was 0.7–0.8, in 4 eyes (13 %) it corresponded to 0.1–0.4. Conclusion. The RayOne Trifocal diffractive IOL provides high visual acuity at all distances, according to our data, 68% for distance, 81% for intermediate distance, and 87% for near, which is consistent with literature data. Keywords: cataract, multifocal IOL, RayOne Trifocal.
Clinical results of transscleral suture fixation of posterior chamber intraocular lenses
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Orenburg branch, Orenburg, Russian  Federation, Lomukhina E.A.
Published: May 2022

Currently there are a large number of modifications for fixing intraocular lenses (IOL) in case of failure of the capsular-ligamentous lens apparatus (CLLA) as a result of intraoperative complications in cataract phacoemulsification, pseudoexfoliation syndrome, chronic uveitis, eye injuries of various origins, as well as a number of congenital conditions. Most ophthalmic surgeons agree that transscleral fixation of the IOL by the supporting elements is the most preferable. Among the main advantages, we can single out a more anatomically correct IOL position, the absence of contact between the lens and the iris, the least number of intra- and postoperative complications such as hyphema, hemophthalmus, pupil deformity, and macular edema. Purpose. Using clinical examples, to present the results of surgical treatment of patients with failure of the capsular-ligamentous apparatus of the lens with implantation and transscleral suturing of the IOL. Material and methods. From 2018 to 2021 we operated on 145 patients (148 eyes) with CLLA failure. All patients underwent transscleral IOL fixation. Results. In all cases, there was a stable increase in visual acuity. There were no such serious intra- and postoperative complications as hemorrhagic (hyphema, hemophthalmia, suprachoroidal hemorrhages), as well as inflammatory (anterior, posterior uveitis, endophthalmitis). Descemetitis and corneal edema were not recorded. However, in 8 eyes in the early postoperative period, IOL rotation along the axis was observed, which required repeated intervention. In 12 eyes there was an increase in intraocular pressure. After the appointment of hypotension drops, compensation of ophthalmotonus was noted. In 2 cases, microinvasive surgery was required for uncompensated glaucoma. Conclusion. One of the modifications of the transscleral technique ab interno for IOL suturing, presented by us, allows achieving high, stable functional results. Keywords: cataract phacoemulsification, intraocular lens, weakness of the capsular-ligamentous apparatus of the lens, transscleral suturing.
Spor Eğitimi Veren Yükseköğretim Kurumlarındaki Personelin Örgüt Kültürü ve Örgütsel İklimi
Authors: YÜCEANT Metin , BALANLI Orhan Fatih , ÜNLÜ Hüseyin
Published: May 2022

Bu çalışmanın amacı, üniversitelerin spor eğitimi veren yükseköğretim kurumlarında çalışan idari personelin örgüt kültürü ile örgütsel iklimi düzeylerini farklı değişkenler açısından incelemek ve arasındaki ilişkiyi tespit etmektir. Araştırma grubunu, farklı üniversitelerde görev yapan toplam 200 idari personel oluşturmuştur. Veri toplama aracı olarak Harrison (1970) tarafından geliştirilen ve Mamatoğlu (2004) tarafından Türkçe’ye uyarlanan “Örgüt Kültürü Ölçeği” ile Rogg vd., (2001) tarafından geliştirilen ve Özdemir (2006) tarafından Türkçe’ye uyarlanan “Örgütsel Iklim Ölçeği” kullanılmıştır. Verilerin analizinde tanımlayıcı istatistiklerden aritmetik ortalama ve standart sapma tekniklerinden yararlanılmıştır İdari personelin örgüt kültürü ile örgütsel iklimi düzeylerinin, cinsiyet açısından farklılaşıp farklılaşmadığının belirlenmesinde t-testi ve kurumda çalışma süresine göre farklılaşıp farklılaşmadığının belirlenmesinde tek yönlü varyans analizi (Anova) kullanılmıştır. İdari personelin örgüt kültürü ve örgütsel iklimi düzeyleri arasındaki ilişkiyi belirlemede Pearson korelasyon katsayısı tekniği ve yordayıcılığını belirlemek amacıyla da çoklu regresyon analizi kullanılmıştır. Araştırmada elde edilen sonuçlarda; idari personelin algıladığı örgüt kültürü ve örgütsel ikliminin yüksek olduğu görülmüştür. Cinsiyet değişkeni açısından örgüt kültürü ve örgütsel iklimi düzeylerinde anlamlı bir farklılığa rastlanmazken; kurumda çalışma süresi değişkeni açısından anlamlı bir farklılığa rastlanmıştır. Araştırmada örgüt kültürü ölçeği ile örgütsel iklim ölçeği alt boyutları ve genelinde pozitif yönlü anlamlı güçlü bir ilişki görülmüştür. Ayrıca örgüt kültürünün, örgütsel iklimi üzerinde güçlü bir yordayıcı olduğu tespit edilmiştir.
Formation of Substituted Benzo[a]heptalenes via Bergman Cyclization of Vicinal Di(ethynyl)-heptalenes
Authors: Abou-Hadeed Khaled
Published: May 2022

By Hafner's synthesis, dimethyl heptalene-4,5-dicarboxylates are easily available from azulenes and dimethyl acetylene-dicarboxylate. Treatment with Takai reagent leads to 4-acetylheptalene-5-carboxylates, which by the procedure of Negishi et al. are further transformed into 4-ethynyl-heptalene-5-carboxylates. Reduction to heptalene-5-methanols, followed by Swern oxidation yields the corresponding heptalene-5-carbaldehydes. Treatment with trimethylsilyldiazomethane in the presence of butyllithium gives 4,5-di(ethynyl)-heptalenes, which on heating in chlorobenzene in the presence of cyclohexa-1,4-diene are transformed into benzo[a]heptalenes.
L’étrange pouvoir de la métaphore filée : le cas des descriptions œnologiques des vins dits « nature »
Authors: COUÉGNAS Nicolas
Published: May 2022

Les descriptions œnologiques des vins nature ont adopté une rhétorique de la transgression qui à la fois permet une identification des vins nature et une démarcation par rapport aux vins conventionnels. L’une des formes de transgression, utilisée notamment dans les guides consacrés au domaine, consiste dans l’exploitation débridée de métaphores filées au contenu sémantique plus ou moins surprenant dans le contexte œnologique. Nous faisons l’hypothèse que ces métaphores filées, formes de répétitions particulièrement visibles dans les textes, possèdent une productivité sémantique qui dépasse le simple effet de transgression et participent pleinement à la réussite de la mise en discours des sensations de la dégustation. Ces métaphores filées se présentent comme des jeux d’intégration conceptuelle (Fauconnier, Gréa) entre domaines sémantiques qui alimentent le tissu figuratif caractéristique de l’effort de mise en discours de la sensorialité.
Étude de la cohérence discursive dans la relation de soin à travers les emplois fonctionnels de mais
Authors: Auriac-Slusarczyk Emmanuèle , Delsart Aline , Pironom Julie
Published: May 2022

L’étude porte sur les emplois du marqueur de cohérence discursive mais étudié en contexte de soin. Dans le cadre d’un projet, DECLICS, nous nous sommes focalisés sur la distribution fonctionnelle de mais en fonction du rôle du locuteur (médecins vs thérapeutes). En appui sur la littérature scientifique, trois macro-fonctions de mais (interlocutive-interactionnelle, logico-argumentative et logico-sémantique) sont décomposées en 17 types dont 16 sont présents dans le corpus DECLICS2016. Le relevé systématique des 122 occurrences de mais présentes dans le corpus a permis d’étudier la fréquence d’emplois comparatifs entre médecins et thérapeutes. Les résultats quantitatifs indiquent que les médecins emploient davantage mais que les thérapeutes, ce, indépendamment de leur service hospitalier. Grâce à une analyse qualitative, nous éclairons ensuite les mécanismes interactionnels en jeu lors des entretiens thérapeutiques médicaux vs cliniques, en déterminant les fonctions prépondérantes, secondaires et tertiaires assignables à chacune des 122 occurrences de mais. Sur ces 122 occurrences d’emplois, 32 occurrences sont le fait d’une fonction prépondérante unique, 80 emplois correspondent à une bi-fonctionnalité du marqueur et 10 d’une tri-fonctionnalité. Les résultats montrent que les macro-catégories interactionnelles et sémantiques permettent la distinction des rôles des soignants, et on constate un lien entre l’utilisation de la fonction prépondérante argumentative et la fonction secondaire logico-sémantique de type circonstanciel. Les résultats ont permis d’extraire deux patterns d’emplois de la tri-fonctionnalité de mais, utilisée presque exclusivement par les thérapeutes. Cette étude montre que les médecins utilisent mais pour activer des opérations logico-argumentatives, les thérapeutes activant préférentiellement un but interactionnel.
Le rôle de l’anamnèse dans la co-construction du diagnostic
Authors: HUYS Viviane
Published: May 2022

Parce que la relation de soin repose en plus de l’examen clinique sur des interactions dialogiques entre un soignant et un patient, elle est soumise à des conventions qui encadrent l’interrogatoire thérapeutique qui la structure. Néanmoins, selon que le médecin convoque ou non la mémoire que possède le patient de sa propre histoire médicale, il augmente ou réduit les possibilités d’associer ce dernier à l’interprétation d’une symptomatologie. Ainsi, nous verrons que l’anamnèse, considérée comme un aspect non négligeable de la prise en charge du patient, peut contribuer à faciliter l’émergence d’un diagnostic co-construit.
Construction discursive des valeurs sociales complexes et sémantisme des valeurs modales épaisses. Retour à une vie normale
Authors: GALATANU Olga
Published: May 2022

Cet article a pour objectif de proposer et argumenter la thèse de l’existence de trois niveaux de complexité des valeurs modales lexicalisées : valeurs modales fondamentales ou fines (bien, mal, beau, laid, etc.), valeurs modales épaisses (cruauté, vertu, liberté, égalité, normalité, etc.), valeurs sociales complexes (démocratie, république, etc.). Le cadre théorique dans lequel s’inscrit cette thèse se situe à l’interface d’une approche sémantique unifiée des modalités et de la modalisation discursive, la Théorie sémantique unifiée de la Modalisation Discursive (TMD), et des approches philosophiques qui s’interrogent sur les distinctions fait/valeur, concept (éthique) fin/concept (éthique) épais. Cette approche théorique des valeurs modales et des valeurs sociales est l’un des développements habilités par la Sémantique des Possibles Argumentatifs (SPA). Nous allons illustrer notre propos avec l’analyse d’une valeur sociale complexe, une/la vie normale, qui incorpore dans son sémantisme la valeur modale épaisse normalité et qui se charge dans l’inter-discours actuel de valeurs axiologiques positives.
Les statuts des locuteurs dévoilés par l’usage des répétitions locales en contexte de soin
Authors: Delsart Aline
Published: May 2022

L’étude porte sur les fonctions pragmatiques de la répétition locale dans des entretiens oraux. Nous nous focalisons sur les hétéro-répétitions locales en contexte d’interaction dans une visée pragmatique afin d’analyser la relation interlocutive dans un contexte de soin. Sont sélectionnés douze entretiens du corpus DECLICS2016 conduits entre deux locuteurs : un patient et un médecin ou un patient et un thérapeute d’orientation psychanalytique. Nous déterminons, dans ce contexte interlocutoire, les fonctions pragmatiques liées à l’usage de l’hétéro-répétition locale et vérifions si elles caractérisent le statut du locuteur. Sur un total de 186 hétéro-répétitions locales, nous avons identifié huit fonctions pragmatiques : la confirmation, la précision, la rectification, la réponse‑reprise, le ciblage, le partage de savoir, la reprise de sens en écho, le questionnement. On constate que les fonctions se répartissent différemment selon le statut du locuteur. Les patients utilisent prioritairement la répétition locale dans un but de confirmation (dans 59 % des cas), les médecins favorisent plutôt le partage de savoir (dans 48 % des cas) et les thérapeutes usent de la répétition dans un but phatique pour maintenir l’échange (dans 68 % des cas). Ces résultats indiquent que les voix énonciatives des locuteurs confirment au plan performatif leurs statuts respectifs. Notre étude, en contexte de soin hospitalier, montre que la répétition locale est un indicateur fiable pour identifier chacun des interlocuteurs et pour caractériser la relation interlocutive.
Les Nardal : Textes, co-textes, contextes
Authors: BERTIN-ELISABETH Cécile
Published: May 2022

Il est d’usage de rappeler la mobilisation du monde noir entre Harlem Renaissance et Négritude. L’action des sœurs Nardal n’a-t-elle pas été non seulement pionnière, mais aussi centrale du point de vue conceptuel à cet égard ? Et pourtant, comme le montre l’évolution du regard d’une autre femme auteure : Maryse Condé, la reconnaissance de l’action primordiale des sœurs Nardal a tardé. Joseph Zobel a été l’un des rares auteurs à prendre position dans cette période d’oubli de ces intellectuelles d’exception. En somme, quelle place est alors accordée à ces femmes et quelle place revendiquent-elles ? Les enjeux de l’engagement des sœurs Nardal sont transcrits dans des textes-clés qu’il convient d’insérer dans leur contexte.
Le Paris créole des sœurs Nardal : une rétrospective historique (XVIIIe-XXe siècles)
Authors: NOËL Erick
Published: May 2022

Paris, Ville-Lumière, a dès l’aube de la colonisation vu arriver les premiers créoles, issus des « Isles d’Amérique », dans le sillage de planteurs qui les ont retenus surtout comme domestiques. Malgré les lois d’abolition, leur situation demeure précaire, même après 1848, en raison d’un rejet persistant de la classe politique, du Second Empire à la Troisième République. Néanmoins, l’éveil d’une culture particulière, mise en avant dans l’euphorie des années folles, revalorise une perception des colonies qui éclate en 1935 dans les festivités du tricentenaire des Petites Antilles françaises. C’est dans ce climat complexe, où se fait aussi jour une vision inédite de l’Afrique plus récemment colonisée, qu’émerge la figure des sœurs Nardal, pionnières d’une expression ultra-marine en France métropolitaine.
Paulette Nardal ou le jeu du féminisme au prisme du genre grammatical
Authors: Mencé-Caster Corinne
Published: May 2022

La préoccupation de Paulette Nardal pour le sort des femmes noires et en particulier des femmes antillaises est indéniable. En quoi ces écrits, entre version en français et en anglais, permettent-ils de retrouver la marque d’une conscience genrée et/ou d’une conscience de race ? Analyser de façon renouvelée les textes majeurs de Paulette Nardal s’impose pour ce qui est de l’utilisation du genre grammatical afin de montrer comment elle crée un discours « genré » qui affiche sa solidarité avec les grandes luttes identitaires de son époque.
Imagerie 3D par microscopie multiphotonique appliquée aux sciences du vivant : la chaine instrumentale et computationnelle FAMOUS
Authors: Lefort Claire , Chalvidal Mathieu , Parenté Alexis , BLANQUET Véronique , Massias Henri , MAGNOL Laetitia , Chouzenoux Emilie
Published: May 2022

Nous présentons une nouvelle stratégie instrumentale et computationnelle appelée FAMOUS (pour fast algorithm for three-dimensional (3D) multiphoton microscopy of biomedical structures) basée sur une approche de microscopie multiphotonique assistée par calcul. Le but est l’amélioration visuelle des images d'échantillons biologiques épais offrant ainsi un nouveau point de vue sur les structures biologiques. L'approche de post-traitement repose sur un algorithme de restauration d'image régularisé, alimenté par une estimation 3D précise de la fonction d'étalement du point (Point Spread Function en anglais, PSF) de l'instrument sur toute la profondeur des structures. Cette dernière étape revient à mesurer, grâce à un algorithme d'ajustement de modèle avancé, les distorsions variant en profondeur de l'image résultant de la combinaison entre la contribution instrumentale et les hétérogénéités du milieu. Les performances du pipeline FAMOUS sont évaluées pour un milieu hétérogène constitué d’un muscle entier de souris. La génération de seconde harmonique (SHG), émise par l'assemblage des chaines de myosine du muscle est enregistrée. Les artefacts optiques issus de la chaîne d'acquisition incluant des hétérogénéités dans les 3 dimensions sont estimés avec les spécificités propres à l’échantillon puis retirées numériquement. Des images brutes et restaurées sur 5 µm de l’ultrastructure fine du muscle illustrent la robustesse du pipeline FAMOUS.
Surfactin and surfactin-like production, purification, and application at marine environments
Authors: Dobler Leticia , Breda Gabriela Coelho , Maria Rocha Patricia , de Paiva Wilza Kímilly Vital , dos Santos Everaldo Silvino , de Oliveira Ricardo Rodrigues
Published: May 2022

Surfactin, a biosurfactant with great activity on interfaces, have been reported as a great substitute to non-renewable sources, non-biologically synthesized surfactants. It is expected to see more studies at the next years evolving its application, including on marine environments, especially ones impacted with petroleum or other contaminants. In this review we address in details the main aspects of surfactin production, including main microorganisms, cultivation modes, pathways and conditions. We address the main aspects of surfactin production by Bacillus subtilis with the different strategies explored to reach this bioprocess up to large scale, as well as the main challenges encountered. As well, is detailed its recovery and purification methods, that generally combine two or more steps as acid precipitation, solvent extraction, liquid membrane extraction, foam fractionation and membrane-based techniques. We also provide a brief summary of its potential application on marine environments, and our prospects from future application, as a brief outlook on physiochemistry characteristics of the main molecules.
Implementation of telescoping boxes in adaptive steered molecular dynamics (ASMD)
Authors: Zhuang Yi , Thota Nikhil , Quirk Stephen , Hernandez Rigoberto
Published: May 2022

Long-time dynamical processes, such as those involving protein unfolding and ligand interactions, can be accelerated and realized through steered molecular dynamics. The challenge has been the extraction of information from such simulations that generalize for complex nonequilibrium processes. The use of Jaryzinski's equality opened the possibility of determining the free energy along the steered coordinate, but sampling over the nonequilibrium trajectories is slow to converge. Adaptive steered molecular dynamics (ASMD) and other related techniques have been introduced to overcome this challenge through the use of stages. Here, we take advantage of these stages to address the numerical cost that arises from the use of the very large solvent boxes required to simulate the entirety of the steered coordinate. We introduce a scheme, called a telescoping box, within ASMD in which we adjust the solvent box between stages, and thereby vary (and optimize) the required number of solvent molecules. We have benchmarked the method on a relatively long alpha-helical peptide, Ala30, with respect to the potential of mean force and hydrogen bonds. We show that the use of telescoping boxes introduces little numerical error while significantly reducing the computational cost.
Advanced materials engineering in historical gypsum plaster formulations
Authors: Mishmastnehi Moslem , Van Driessche Alexander , Smales Glen , Moya Alicia , Stawski Tomasz
Published: May 2022

We show how historical gypsum plaster preparation methods affect the microstructure and the nanoscale hydrophilic properties of the final stucco materials. We reproduced a traditional Persian recipe (Gach-e Koshteh, ~14th c. AD), which involves a continuous mechanical treatment during plaster hydration. The Koshteh samples were compared with a lab-replicated historical recipe from Renaissance Italy (Gesso Sottile, ~15th c. AD), and contemporary plaster. The Iranian recipe induces the formation of gypsum platelets displaying preferential orientation in the plaster bulk. In contrast, the Italian and regular plasters comprise a typical needle-like morphology of gypsum crystals. The platelets in Koshteh expose the hydrophilic {010} face of gypsum in a much more pronounced manner than needles. Consequently, the Iranian plaster exhibits enhanced wettability, enabling their direct use for water-based decoration purposes without mixing it with any binder material, as is the case for Sottile. Contrary, the preparation of Sottile promotes the exposure of the more hydrophobic gypsum faces conferring a more water repelling character to this type of plaster. These observations highlight the development of advanced functional plaster materials already during the pre-modern era.
Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral Duva florida, Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme.
Authors: Avalon Nicole E. , Nafie Jordan , De Marco Verissimo Carolina , Warrensford Luke C. , Dietrick Sarah G. , Pittman Amanda R. , Young Ryan M. , Kearns Fiona L. , Smalley Tracess , Binning Jennifer M. , Dalton John P. , Johnson Mark P. , Woodcock H. Lee , Allcock A. Louise , Baker Bill J.
Published: May 2022

Cold water benthic environments are a prolific source of structurally diverse molecules with a range of bioactivities against human disease. Specimens of a previously chemically unexplored soft coral, Duva florida, were collected during a deep-sea cruise that sampled marine invertebrates along the Irish continental margin in 2018. Tuaimenal A (1), a cyclized merosesquiterpenoid representing a new carbon scaffold with a highly substituted chromene core, was discovered through exploration of the soft coral secondary metabolome via NMR-guided fractionation. The absolute stereochemistry was determined through vibrational circular dichroism. Functional biochemical assays and in silico docking experiments found tuaimenal A selectively inhibits the viral main protease (3CLpro) of SARS-CoV-2.
Conformal and superconformal chemical vapor deposition of silicon carbide coatings
Authors: Huang Jing-Jia , Militzer Christian , Wijayawardhana Charles , Forsberg Urban , Pedersen Henrik
Published: May 2022

The approaches to conformal and superconformal deposition developed by Abelson and Girolami for a low temperature, low pressure chemical vapor deposition (CVD) setting relevant for electronic materials in micrometer or sub-micrometer scale vias and trenches, are here tested in a high temperature, moderate pressure CVD setting relevant for hard coatings in millimeter scale trenches. Conformal and superconformal deposition of polycrystalline silicon carbide (SiC) can be deposited by decreasing the deposition temperature, increasing the precursor partial pressure, or adding HCl as a growth inhibitor. The conformal deposition at low temperatures is ascribed to slower kinetics of the precursor consumption along the trench depth, whereas the impact of high precursor partial pressure and addition of inhibitor is attributable to surface-site blocking. By combining these three deposition conditions, a superconformal SiC coating with 2.6 times higher thickness at the bottom compared to the top of a 1 mm trench was achieved.