bluuebunny/crossref_metadata_2025 huggingface dataset:
Faktor-Faktor Yang Mempengaruhi Kualitas Pelayanan Publik Di Kantor Desa
Authors: Mustamin Mustamin , Rahm Siti Atika , Hidayat Rahmad , Indriani Rahma
Published: April 2024

This research was carried out using case studies at the Batuyang Village Office, Pringgabaya District, East Lombok Regency, aiming to determine the factors that can affect the quality of public services. This study attempted to collect primary data using an open direct questionnaire, to 60 respondents, to ask for their assessment regarding 6 factors/variables that affect the quality of public services at the Village Office. The data that was successfully collected, then processed and analyzed with a Likert Scale. The results of the study show that the factors that influence the quality of public services at the Village Office include: the work motivation of the bureaucracy and village apparatus, the ability of village apparatus, social supervision/control, organizational/apparatus behavior, communication and organizational restructuring. According to the respondent's assessment and Likert Scale analysis, the variable that contributes/influences more towards the quality of public services, namely the organizational/apparatus behavior variable is in the Good Category (2.8), then the Good contribution is also followed by the bureaucratic and apparatus work motivation variables as well as the communication variable (2.7), then the variable of the ability of the village apparatus and the variable of social supervision/control (2.6) on the quality of public services, only the organizational restructuring variable whose contribution is not good (2.5). Urgent efforts being made by the Village Government to improve the quality of public services, namely the provision of infrastructure facilities so as to better support public services, such as the availability of online service facilities, creating a Village Information System (SID) and it is time for all villages to have their own websites. Changes in services from a manual system to an online system must be followed by efforts to increase the professionalism of public service officials (village officials) and also need to be revitalized, restructured and deregulated in the field of public services.
Inovasi Pelayanan Pengaduan Masyarakat Call Center 112 Sebagai Wadah Pengaduan Darurat Di Kabupaten Sidoarjo
Authors: Ardhani Diaz , Wahyudi Kalvin Edo
Published: April 2024

Society will always expect the government to provide quality public services.. Providing access to complaints is one of the efforts to improve public services that can be, so public can submit their complaints regarding the services received. The Government of Sidoarjo Regency is seeking to provide maximum service by launching the Call Center 112 emergency complaint forum, which was launched on June 20, 2022. The purpose of this research is to identify and describe the Call Center 112 public complaint service innovation as an emergency complaint forum in Sidoarjo Regency. The type of research used is qualitative with a descriptive approach. The results of the study show that: 1) Relative Advantage: Call Center 112 Innovation has provided benefits for the community to submit complaints. 2) Compatibility: Call Center 112's innovation complies with regulations, community requirements, and previous complaint forums. 3) Complexity. Call Center 112 is said to be quite complicated in technical reporting and operating procedures. 4) Triability.  Call Center 112 has passed the trial stage. 5) Observability: Call Center 112 is easy for OPD to observe, but there is still a lack information on the progress of complaints.
Collaborative Governance dalam Program Rehabilitasi Sosial Rumah Tidak Layak Huni di Kota Surabaya
Authors: Kristin Citra , Wibawani Sri
Published: April 2024

Abstract:  The Social Rehabilitation Program for Uninhabitable Houses abbreviated as rutilahu is a program to improve the quality of housing through repairs as a whole and/or entirely with the principles of acceptability, transparency, accountability, integration, partnership, solidarity, benefits and participation. This study aims to describe in depth the process of collaborative governance in the Social Rehabilitation Program for Uninhabitable Houses in the City of Surabaya. This type of research uses descriptive qualitative techniques with the determining informants through purposive and snowball sampling techniques. Data collection techniques used were observations, interviews, and documentation. Data analysis techniques using "interactive model of analysis" by Miles and Huberman (2014). The collaborative governance process is analyzed by theory (Ansell & Gash, 2007) including face to face dialogue, trust building, commitment to the process, shared understanding, and intermediate outcomes. The results showed that the collaboration process had been successfully carried out at the face to face dialogue, trust building, share understanding, and intermediate outcome stages between the DPRKPP of Surabaya City with BP2P Jawa IV, Baznas Surabaya, YMI ITS, Victory Community Church of Surabaya, KTPR, Bank Mandiri, and from private donor. Meanwhile, the collaboration process at the commitment to the process stage has been quite successful between the parties. In the commitment to the process stage, the majority of the collaborating or participating parties do not yet have written documents that can strengthen their collaborative relationship, so at least a letter of agreement is needed stating or known by the parties concerned.
Efektivitas Strategi Satuan Polisi Pamong Praja Kota Madiun Dalam Penertiban Pedagang Kaki Lima
Authors: Sari Dina Safira Retna , Wahyudi Kalvin Edo
Published: April 2024

Efektivitas Strategi Satuan Polisi Pamong Praja Kota Madiun Dalam Penertiban Pedagang Kaki Lima
Optimalisasi Kinerja Karyawan Dalam Pengelolaan Media Digital Bumdes Sekapuk Melalui Kerangka Kerja Smart Goals
Authors: Safitri Mila Dwi , Abidin Agus Zainal , - Afifuddin -
Published: April 2024

Pengelolaan media digital oleh Badan Usaha Milik Desa (BUMDes) Sekapuk dapat menjadi potensi besar dalam meningkatkan ekonomi pedesaan di tengah era digitalisasi saat ini. Namun, implementasi media digital seringkali tidak optimal, menyebabkan potensi tidak termanfaatkan dengan baik. Penelitian ini bertujuan untuk menganalisis hubungan antara antara SMART Goals dan kinerja karyawan dalam pengelolaan media digital BUMDes Sekapuk agar lebih optimal. Melalui pendampingan dari BUMDes.id dan penerapan kerangka SMART Goals, BUMDes Sekapuk telah menetapkan tujuan spesifik, terukur, dapat dicapai, relevan, dan berbatas waktu. Hasil temuan menunjukkan peningkatan kinerja karyawan dalam mengelola media digital, dengan peningkatan engagement, jumlah pengikut, dan interaksi pengguna yang terukur. Selain itu, implementasi SMART Goals terbukti relevan dengan visi BUMDes Sekapuk dan telah membawa dampak yang cukup positif. Penelitian ini menyarankan peningkatan program pelatihan dan adopsi teknologi terkini serta tetap mengikuti perkembangan tren media sosial untuk mendukung efisiensi kerja di masa depan. Dengan tetap mengikuti perkembangan teknologi dan tren media sosial, BUMDes Sekapuk dapat tetap relevan dan kompetitif di era digital. Penelitian selanjutnya perlu mengkaji dampak langsung optimalisasi kinerja karyawan terhadap pertumbuhan pendapatan dan keberlangsungan BUMDes secara keseluruhan
Psikiyatrik Tanı Alan Çocuk ve Ergenlerin Annelerinin Kaygı-Depresyon ve Suçluluk-Utanç Düzeylerinin Çocuğun Tanısı ile İlişkisi
Authors: Cerit Esin , Mınıksar Dılsad
Published: April 2024

Amaç: Araştırmada, psikiyatrik tanısı olan çocuk ve ergenlerin annelerinin depresyon, kaygı ve suçluluk -utanç düzeylerinin çocuğun tıbbi tanısı ile ilişkisinin belirlenmesi amaçlanmıştır.

Gereç ve Yöntemler: Araştırma kesitsel desende, ilişki arayıcı bir çalışmadır. 15.10.2021-15.02.2022 tarihleri arasında ***Üniversitesi Sağlık Uygulama ve Araştırma Merkezi, Çocuk ve Ergen Psikiyatrisi Polikliniğine başvuran 92 hastanın annesi üzerinde yapılmıştır. Veriler, Kişisel Bilgi Formu, Beck Depresyon Envanteri, Beck Anksiyete Ölçeği, Suçluluk Utanç Ölçeği ile toplanmıştır. Çalışma verileri değerlendirilirken kategorik değişkenler için frekans dağılımı (sayı, yüzde), sayısal değişkenler için tanımlayıcı istatistikler (ortalama, standart sapma, minimum, maksimum) verilmiştir. Bağımsız Örneklem t Testi, Tek Yönlü Varyans Analizi, Mann Whitney U testi, Pearson Korelasyon Analizi ve basit doğrusal regresyon analizi verilerin analizinde kullanılmıştır.

Bulgular: Annelerin çocuklarının psikiyatrik tanısına göre BDÖ ve BAÖ puan ortalamaları arasında istatistiksel olarak anlamlı farklılık olduğu saptanmıştır (p
SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN VENDOR IT MAINTENANCE MENGGUNAKAN PENDEKATAN WASPAS
Authors: Fatmayati Fryda , Riyanto Umbar , Rahmadian Jefri , Pahlevi Omar
Published: April 2024

IT maintenance is important for a company because these activities are carried out to maintain and support the optimal performance of a company's IT systems and infrastructure. Generally, selecting an IT maintenance vendor is done by collecting vendor data and then evaluating it based on the desired criteria. This, of course, results in the time it takes to make a choice and makes it difficult to determine the best option. If you choose the wrong IT maintenance vendor, it will result in disrupting the company's stability. This research was conducted with the aim of developing a decision support system that can be used to determine the IT maintenance vendor that best suits their needs and preferences using the WASPAS (Weighted Aggregated Sum Product Assessment) approach. This method is used to determine the best option through weighted addition and multiplication, producing a final value that reflects the extent to which each option can meet the specified criteria. From the existing case studies, the best alternative was obtained, namely: Microsis (A4) got a preference value of 0.8769, followed by ICT Canopy (A1) with a preference value of 0.8613, Pillar IT (A2) with a preference value of 0.8408, Indocom Niaga (A5) with a preference value of 0.8180, and Sasana Digital (A3) with a preference value of 0.7389. The usability test carried out received a score of 88%, which indicates that the system is suitable for use.
PENGARUH KEMASAN BLISTER, BRAND AWARENESS, HARGA DAN PRODUCT PLACEMENT DALAM DRAMA KOREA TERHADAP MINAT BELI PRODUK PERMEN KOPIKO DI BANYUWANGI
Authors: Auliya Ardina Juhroh Liya , Widagdo Suwignyo , Amin Saiful
Published: April 2024

This study aims to determine the effect of blister packaging, brand awareness, price and product placement in Korean dramas on buying interest in kopiko candy products in Banyuwangi. The population used in this study were respondents who had watched Korean dramas in Banyuwangi. Sampling using purposive sampling technique, namely Non-Probability Sampling. The sample used was 100 respondents who met the criteria. The criteria are age 15 and over, have watched Korean dramas, know the product placement of kopiko in Korean dramas, know the product of blister packs of kopiko candy, have ever bought a kopiko candy product. The analytical techniques used in this study were instrument tests (validity and reliability tests), classical assumption tests (normality test, multicollinearity test and heteroscedasticity test, multiple linear regression tests, coefficient of determination R^2 test, hypothesis testing (t test and F).Based on the results of the study, it shows that blister packaging and brand awareness, price, and product placement simultaneously influence purchase intention, while blister packaging and brand awareness partially have no effect on purchase intention. The coefficient of determination R^2 is 65.5% of buying interest. While the rest is influenced by other variables.
Measurement of Serum Stromelysin-2 Level in Iraqi Patients with Subclinical and Clinical Hypothyroidism
Authors: M. Ibraheem Rand , A. Hamdi Rana , M. Kadam Satar
Published: April 2024

الخلفية: قصور الغدة الدرقية تحت الإكلينيكي وقصور الغدة الدرقية والذي يتميز بزيادة مستويات الهرمون المنبه للغدة الدرقية وهرمونات الغدة الدرقية الطبيعية أو غير الطبيعية. قد يكون لقصور الغدة الدرقية دور في خلل شحميات الدم وارتفاع ضغط الدم وتصلب الشرايين والضعف الإدراكي والخلل العصبي العضلي والعقم. ترتبط العوامل المتعددة التي تزيد من خطر الإصابة بأمراض القلب والأوعية الدموية بالسمنة، بما في ذلك متلازمة التمثيل الغذائي، وعسر شحميات الدم، ويظهر المزيد من الأدلة أن عوامل الخطر أكثر شيوعًا لدى الأشخاص الذين يعانون من السمنة المفرطة وقد تعمل معًا لزيادة مخاطر الإصابة بأمراض القلب والأوعية الدموية. سترومليسين -2 ، الذي يشار إليه أيضًا باسم مصفوفة ميتالوبروتيناز -10 ، هو إنزيم تنتجه الخلايا التي تكسر المصفوفة خارج الخلية في الأنسجة المختلفة ، بما في ذلك الأوعية الدموية. أظهرت الأبحاث أن مستويات سترومليزين -2 تزداد في البلاعم النشطة وخلايا العضلات الملساء في آفات تصلب الشرايين.
 
الهدف من الدراسة: قياس مستويات سترومليسين -2 في مصل الدم في المرضى الذين يعانون من قصور الغدة الدرقية تحت الإكلينيكي والسريري، ومقارنة مستوياتهم مع الضوابط الصحية. أيضًا، لتقدير العلاقة بين مستويات المصل سترومليسين -2 ومقاييس الجسم البشري (مؤشر كتلة الجسم ومحيط الخصر ونسبة الخصر إلى الورك).
 
المرضى والطرق: تم جمع مائة وثلاثين عينة من الأفراد العراقيين الذين حضروا مركز بغداد للعلاج الإشعاعي والطب النووي والمختبرات الخاصة، من 23 إلى 70 سنة، وتم تصنيف ثلاث مجموعات: المجموعة أ ، والتي ضمت 45 مريضاً تم تشخيصهم بقصور الغدة الدرقية الإكلينيكي. المجموعة ب، والتي ضمت 43 مريضاً تم تشخيص إصابتهم بقصور الغدة الدرقية تحت الإكلينيكي. والمجموعة C، والتي تضمنت 42 مشاركًا يتمتعون بصحة الغدة الدرقية كعنصر تحكم. تضمنت فحوصات الدم قياس سترومليسين -2 في مصل الدم ومعايير القياسات البشرية (مؤشر كتلة الجسم ومحيط الخصر ونسبة الخصر إلى الورك) لكل فرد.
 
النتيجة: أظهرت نتائج الدراسة أن متوسط مؤشر كتلة الجسم أعلى بكثير (P = 0.001) ومحيط الخصر (P = 0.001) ونسبة الخصر إلى الورك (P = 0.001) في مرضى قصور الغدة الدرقية السريري وتحت السريري مقارنةً بمجموعة التحكم. بالإضافة إلى ذلك، أظهرت النتائج زيادة معنوية في متوسط قيمة المصل سترومليسين -2 (P = 0.001) في مرضى قصور الغدة الدرقية السريري وتحت الإكلينيكي مقارنة بمجموعة السيطرة الصحية. في المرضى الذين يعانون من مجموعة قصور الغدة الدرقية السريرية، كانت هناك ارتباطات إيجابية كبيرة بين مصل ستروميليسين -2 ومؤشر كتلة الجسم (r = 0.413) ، p  = 0.005) ، محيط الخصر (r  = 0.406 ،  p = 0.006) ، ونسبة الخصر إلى الورك ( r  = 0.367 ،
(p = 0.013).
 
الخلاصة: زيادة وزن الجسم لدى مرضى قصور الغدة الدرقية السريري وتحت السريري، ممثلة بمؤشر كتلة الجسم ومحيط الخصر ونسبة الخصر إلى الورك مما يشير إلى خطر الإصابة بأمراض القلب والأوعية الدموية. علاوة على ذلك، فإن مرضى قصور الغدة الدرقية السريري وتحت السريري لديهم مستوى أعلى من سترومليسين -2، والذي يُعتقد أنه علامة على الأوعية الدموية ويمكن استخدامه للتنبؤ بتصلب الشرايين المبكر.
الكلمات المفتاحية: تصلب الشرايين تحت الإكلينيكي، السمنة، سترومليسين -2، قياس الأنثروبومترية.
Relationship between Folate, B12 and Homocysteine levels and Obstetrical Outcomes in Preterm Premature Rupture of Membrane
Authors: S. Dawood Aya , J. Mohammed Ahmed
Published: April 2024

التمزق التلقائي لأغشية الجنين قبل بدء الولادة الذي يحدث قبل اكتمال 37 أسبوعًا من الحمل ، يشار إليه على أنه تمزق الأغشية المبكر قبل الولادة . يحدث في 2٪ من حالات الحمل. يعتمد التنبؤ بـه على تحديد عوامل الخطر المرتبطة واستخدام مؤشرات حيوية محددة لمنع النتائج الضارة على الام والجنين. ان الهدف من الدراسة لمعرفة العلاقة وفهم الدور بين حامض الفوليت ، فيتامين بي 12 والهميوسستين في تمزق الغشاء الامينوسي المبكر قبل حدوث الولادة ولتحديد النتائج من تمزق الغشاء الامنيوسي على الام والطفل . تم تطبيق دراسة حالة وشواهد ، اشتملت الدراسة على 100 امرأة حامل بجنين واحد حي مع عمر حمل للمرضى يتراوح بين 24 الى 36 أسبوعًا وستة أيام من الحمل .أجريت الدراسة في قسم أمراض النساء والولادة بمستشفى الخنساء التعليمي للولادة خلال فترة خمسة أشهر وعشرة ايام من 20 / كانون الثاني  إلى 1 / تموز / 2022. وشملت الدراسة 50 امرأة حامل يعانين من تمزق الغشاء الامنيوسي المبكر قبل حدوث الولادة  كمجموعة حالات. 50 امرأة أخرى كانت من النساء الحوامل اللواتي لديهن عمر حمل متطابق مع غشاء سليم وليس لديها ولادة دون أي مضاعفات خلال الحمل كمجموعة ضابطه .وتم تقدير مستوى الفوليت ،  بي 12 والهيموسستين من المصل .ثم تم جمع البيانات وتحليلها احصائيا. ان عوامل الخطورة ذو اهمية لتمزق الغشاء الامنيوسي المبكر قبل الولادة هي : النساء العاملات، والأميات، عدم وجود أو وجود اقل من ثلاثة زيارات لرعاية  الحمل والولادة، الفاصل الزمني القصير بين الحمل ، وجود ولادة مبكرة سابقة أو تمزق الأغشية المبكر قبل الولادة ، المدخنات الثانويات ، نقص مستوى الفوليت  ومستوى مرتفع من الهيموسيستين .فيما يتعلق بالبيانات الديموغرافية ومستوى فيتامين بي    12 لم يكن مختلفًا بين المجموعتين. من ناحية أخرى ، كان مستوى الفوليت أقل في مجموعة الحالات تمزق الأغشية المبكر قبل الولادة  منه في المجموعه الضابطه.  كان مستوى الهيموسيستين أعلى بشكل ملحوظ في مجموعة الحالات من المجموعة الضابطة . ارتبط مستوى الهيموسيستين ≥ 28.85 نانومول / مل بحساسية عالية وخصوصية ودقة (90 و 84 و 87٪ على التوالي) ، بالتالي يمكن استخدامه أيضًا كأداة جيدة لاستبعاد التنبؤ بالخطر لتمزق الأغشية المبكر قبل الولادة . بينما يرتبط مستوى الفوليت  ≤3.22 نانوغرام / مل بحساسية معتدلة ونوعية منخفضة. نستنتج من ذلك ان مستوى الهيموسيستين ومستوى الفوليت هو علامة جيدة لتمزق الأغشية المبكر قبل الولادة، بالاضافة الى ارتقاع الهميوسيستين هو احد عوامل الخطورة لتمزق الاغشية المبكر قبل الولادة. مستوى فيتامين بي 12 لم يترافق مع زيادة خطر تمزق الأغشية المبكر قبل الولادة.
ЮРІЙ ВОРОНИЙ – СЛАВЕТНИЙ ВИПУСКНИК КИЇВСЬКОЇ ДЕРЖАВНОЇ МЕДИЧНОЇ АКАДЕМІЇ
Authors: Dubenko Dmytro
Published: April 2024

У роботі висвітлені історичні аспекти біографії випускника Київської державної медичної академії 1921 року – Юрія Юрійовича Вороного. На основі архівних документів зображена хронологія його роботи в Київському медичному інституті на початку 20-х років минулого століття. Описані окремі факти щодо роботи Юрія Вороного у факультетській хірургічній клініці Київського медичного інституту, його переїзду до Харкова. В роботі представлені бі- ографічні факти про одного з вчителів Юрія Вороного - професора Євгена Черняхівського та його експериментальні роботи з судинної хірургії та трансплантації органів.
ОЦІНКА РИЗИКУ ТА ПРОГНОЗУВАННЯ МОЖЛИВОСТІ ВИНИКНЕННЯ ГОСТРИХ ТОКСИЧНИХ ЕФЕКТІВ У ПРАЦІВНИКІВ ПРИ РОБОТІ З ПРЕПАРАТОМ ОБЕРОН РАПІД 240 SC, КС
Authors: Tkachenko Inna , Antonenko Anna
Published: April 2024

питання безконтрольного використання пестицидів досить гостро постає в системі дер-жавного контролю застосування хімічних засобів захисту рослин та носить глобальний характер. Адже, вплив хімічних препаратів становить небезпеку потенційного токсичного впливу на професійні та непро-фесійні контингенти. Тому, вивчення та прогнозування можливих ризиків негативного впливу пестицидів є невід’ємною складовою при впровадженні їх в практичну діяльність сільськогосподарських та приватних фермерських господарств. Метою було прогнозування виникнення гострих токсичних ефектів у працівни-ків, задіяних у обробках сільськогосподарських культур препаратами на основі нового інсектициду спіро-мезіфену та представника авермектинів – абамектину. Матеріали і методи дослідження. Для розрахунку коефіцієнтів можливого інгаляційного отруєння використали фізико-хімічні властивості і норми витратидосліджуваних діючих речовин препарату Оберон Рапід 240 SC, КС, методичні підходи ДСанПіН 8.8.1.002-98, а для визначення можливості виникнення гострих токсичних ефектів, з урахуванням вибірковості їх дії,використали методику Сергєєва С.Г., яка враховує два шляхи потенційного надходження хімічних речовиндо організму – інгаляційний і дермальний. Результати. Згідно з «Гігієнічною класифікацією пестицидів заступенем небезпечності» спіромезіфен та абамектин, а також препарати на їхній основі, відносяться доIV класу небезпечності за коефіцієнтом можливого інгаляційного отруєння,який становив менше 0,5. Запоказниками інгаляційних та дермальних коефіцієнтів вибірковості дії досліджувані сполуки були віднесенідо речовин з високою вибірковістю дії, окрім величини коефіцієнту інгаляційного впливу абамектину, якийстановив менше 100 і дозволив віднести сполуку до речовин з відносно низькою вибірковістю дії. Висновки. Отримані дані свідчать про низьку ймовірність виникнення гострих отруєнь при використанні препара-тів на основі інсектицидів – спіромезіфену та абамектину, а також про їх відносну безпечність та малу вірогідність у виникнення гострих токсичних ефектів при надходженні інгаляційним шляхом та при потра-плянні на шкіру.
KIDNEY STONE DISEASE AND OSTEOPOROSIS -TOPIC ISSUES OF COMORBIDITY
Authors: Kordubailo Ilia , Nikitin Oleg , Nishkumay Olga , Samchuk Pavlo
Published: April 2024

the prevalence of kidney stone disease (KSD) and osteoporosis (OP) increases every year. In the pre-vention of osteoporosis, it is important to consume a sufficient amount of calcium-rich foods in the daily diet, as

well as the use of calcium. One of the important reasons for the insufficient use of calcium-containing products andmedicines is the anxiety not only of patients, but, very importantly, of doctors as much as possible. This has seriousjustification, as nephrolithiasis occurs in approximately 5% of the population, and the risk of developing kidneystones during life is 8-10%. It is believed that secondary hyperparathyroidism, which is caused by hypocalcemiadue to insufficient consumption of calcium-containing products and impaired renal function, leads to increasedbone resorption, formation of kidney stone disease. It is important to consider that against the background ofhypertensive, atherosclerotic kidney disease, tubulo-interstitial lesions of the kidneys with decreasing glomerularfiltration rate decreases the synthesis of 1α-hydroxylase - an enzyme by which 25-hydroxycholecalciferol (25 (OH)active D3, calcium) form of vitamin D3–1.25 dihydroxycholecalciferol (1.25 (OH) 2D3, calcitriol - D-hormone)and secondary hyperparathyroidism develops. In this case, the purpose of correction along with the treatment ofurolithiasis (spa treatment, given the attendance of the presence of KSD, to carry out the distance lithotripsy), intakeof active metabolites of vitamin D (should be started with low doses, independent of the initial PTH concentration,and then titrated based on the PTH response) conducting X-ray densitometry.
СІМЕЙНА СЕРЕДЗЕМНОМОРСЬКА ЛИХОМАНКА УСКЛАДНЕНА ХРОНІЧНОЮ ХВОРОБОЮ НИРОК 5Д. СТ. ОПИС КЛІНІЧНОГО ВИПАДКУ
Authors: Palchukovska Maria , Liksunova Lyudmila
Published: April 2024

даний клінічний випадок демонструє найтяжче ускладнення сімейної середземноморської

лихоманки (ССЛ) - амілоїдоз нирок та бурхливу еволюцію ураження нирок при ССЛ за відсутності ліку-вання. Чоловік, вірмен за національністю, 62 роки, звернувся за консультацією зі скаргами на підвищення

температури тіла протягом місяця до 38 °C у вечірні години, часте сечовипускання, забарвлення сечі втемний колір. Біохімічне дослідження крові виявило підвищення таких показників: креатинін-489 мкмоль/л,

сечовина 28,3 мкмоль/л, сечова кислота 619 мкмоль/л. ШКФ-6мл/хв. Проведена біопсія слизової щоки на амі-лоїдоз - депозитів амілоїду не виявлено. Встановлено діагноз ССЛ, ХХН 5д. ст. Початок лікування. Вста-новлення катетеру Тенкхоффа. Лікування постійним амбулаторним перитонеальним діалізом (ПАПД) в

режимі 4 обміна розчином глюкози 1,36% 2,0 л. Динаміка лікування позитивна за наявності постійною

замісної терапії. Особливістю даного клінічного випадку є підступний розвиток вторинного (АА) амілоїдо-зу у неконтрольованого пацієнта з розвитком термінальної стадії хронічної хвороби нирок (ХХН). Даний

випадок демонструє необхідність постійного обстеження та лікування хворих з термінальною стадієюХХН нирковою замісною терапією, що значно знижує якість життя пацієнта.
EMOTIONALLY-EFFECTIVE DISORDERS IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Nikolaychik A.M. , Kozlova Yu.V. , Kolesnik T.V.
Published: April 2024

The aim of the work was to study the effect of high blood pressure and stress factors in the psycho-emotional state of elderly patients. Ground the pathogenic mechanism of affective disorders in patients with arterial hypertension.

The materials and methods. 45 patients were examined. They were divided into two groups – primary and control. The main group includes 28 patients diagnosed with GD of stage III, aged 60 to 95 years (83 ± 1.09 years). In the main group of 20 patients (72%) had a combination of GD with ischemic heart disease and angina pectoris (the III functional class), in 4 (14%) patients with GD was complicated by postinfarction cardiosclerosis, in 4 (14%) – cerebral circulation disorder. The control group consisted of 17 normotensive patients without cardiovascular diseases, in age from 61 to 77 years (67.8 ± 0.93 years). Groups were matched according to the age and gender of the patients.

The results. This research showed the significant differences between two control groups of patients. In patients with arterial hypertension, the level of anxiety is increased on 20%, depression on 27% and stress on 27%. Stress in this work can be considered as a risk factor for the development of permanent increase of blood pressure due to the activation of the sympathoadrenal system. That is lead to a negative effect of arterial hypertension on the dorsolateral frontal cortex due to pathological changes in the structure of the vascular wall. Was detected an increase in anxiety level on 20%, depression and stress on 27%, respectively, in the main observation group.

Conclusion. The information received during the course of this work, definitely, requires more extensive clinical studies, but indicate some dependence of the influence of arterial hypertension on the structure of the brain. Primarily it is affecting on the striatal complex and dorsolateral frontal cortex, which lose certain connections during the disorders. Moreover, in the elderly patients of the main group, there is a cerebral blood supply disorder, which leads to cognitive dysfunctions and in the future may cause geriatric dementia.
IMMUNOLOGICAL CHANGES AS A RESULT OF HEAD INJURY, THAT LEAD TO DEPRESSION
Authors: Bedlinskyi V.O.
Published: April 2024

Relevance. Depression is the one of the most frequent psychiatric conditions, that is developed as a result of head injury. The frequency of post-traumatic depression accounts from 6% to 77%. The etiology is still unknown, although one of the main etiopathogenic link are changes in the immunological reactivity.

Aim. Analysis of the main mechanisms of the influence of immune system, triggered by head injury, on development of depression symptoms. Methods. Data from Web of Science, Pubmed and Google Scholar were analyzed with key words: depression, organic depressive disorder, head injury, immune response.

Results. Current methods in the treatment of the organic depression can’t fully influence on main pathogenic link. It can complicate the treatment and lead to exacerbation or delayed outcomes of the head injury.
LIMB AMPUTATIONS IN MILITARY PERSONNEL DUE TO ARTILLERY STRIKES IN THE AREA OF THE ANTITERRORIST OPERATION (ATO) IN EAST UKRAINE
Authors: Buryanov A.A. , Bespalenko A.A. , Tsema Ie.V. , Dinets A.V.
Published: April 2024

The aim – to investigate and evaluate amputations of extremities due to the trikes of artillery against military personnel of the Armed Forces of Ukraine (AFU) within the area of the Antiterrorist Operation (ATO) in East Ukraine. 

Patients and methods. All military personnel of the AFU within ATO was eligible for the study with diagnosis of limb amputations in the period from 01.06.2014 to 30.06.2016, and who were treated in hospitals of the Ministry of Defense of Ukraine. Among 7091 patients with injuries, 152 patients with limb amputations were identified.

Results and discussion. Out of 152 patients, 73 (48%) amputations were due to artillery strikes or mine shelling, while other causes of amputation were identified in 79 (52%) of the wounded. Amputations of the middle 1/3 of the arm were more frequently diagnosed in the artillery injury group as compared to the group of another cause of amputation (p = 0.011). The use of artillery by the terrorists against the AFU resulted in more often in amputation of one limb, which was detected in 70 (96%) patients in this group, as compared with 65 (82%) patients in the group of another cause of amputation (p = 0.0093). Analyses of the number of amputated extremities revealed 1 (1.4%) patient with amputation of 2 lower extremities in the artillery fire group, which was 9 times less frequently observed as compared to 9 (11%) patients in the group of another cause of amputation (p = 0.019).

Conclusions: The results of the study confirmed significant role of artillery strikes for the amputation of one limb. High-energy artillery weapons play a minor role in terms of amputations at the level of the middle 1/3 of the upper limb and amputation of the two lower limbs.
HEMODYNAMICS CHANGES IN CHILDREN WITH SEPSIS
Authors: Shadrin V.O. , Yevtushenko V.V.
Published: April 2024

Sepsis is one of the most common causes of mortality in children. The severe course of sepsis is usually associated with the development of septic shock and multiple organ failure. An important component in the comprehensive examination and evaluation of treatment effectiveness is the monitoring of hemodynamic parameters. We aimed to evaluate changes in central and peripheral hemodynamics by echocardiography and doppler ultrasound in children with sepsis.

Material and methods. A retrospective study of cases of septic shock in children aged 0 to 18 years who underwent treatment in the intensive care unit was conducted. Patients were monitored for central and peripheral hemodynamics by echocardiography and doppler ultrasound.

Results. 108 cases of sepsis were investigated. Meningococcus was an etiological factor in 53,7% patients, 0.9% – Staphylococcus, 0.9% – Pneumococcus, 0,9% – Yersinia, and in 41,7% aetiology was not been established. In 12 children from the study group fatal outcome was occurred. Septic shock development was associated with significantly higher rates of heart rate (HR) and an increase in peripheral resistance (RI) indices in the abdominal trunk and renal arteries. Fatal course of the disease was associated with a high rate of heart rate and a decrease in diastolic velocity (V min) in the abdominal trunk and renal arteries.

Conclusion. Echocardiography and ultrasound dopplerography in children with sepsis are the useful tools to evaluate the pattern and extent of cardiovascular dysfunction.

Results of regional blood flow assessment can be a diagnostic criterion for the septic shock and has prognostic value in children with sepsis.
MINI-INVASIVE (PUNCTURE-DRAINING) ECHO-CONTROLLED INTERVENTIONS IN THE PATHOLOGY OF THE ABDOMINAL CAVITY
Authors: Kolosovych A.I. , Sydorenko R.A. , Tsyganok A.M.
Published: April 2024

Puncture-draining interventions under the ultrasound control have become an indispensable effective aid in complex treatment, and in some cases, an independent method of correcting a number of diseases of the abdominal cavity. However, some technological aspects in the execution of the procedure and the postoperative management of patients are left out of the focus of discussion.

The aim – to improve the results of the use of puncture drainages under ultrasound control in abdominal pathology. 

Puncture-draining interventions are applied in 89 patients: with pancreatogenic fluid collections, intra-abdominal complications after abdominal operations, inflammatory processes in the gallbladder, tumor bile duct obstructions, liver abscesses.

An analysis of the effectiveness of the use of puncture and drainage interventions under ultrasound control in pathology of the abdominal cavity organs and retroperitoneal space was carried out. 

Puncture-draining interventions under ultrasound control are an alternative to open surgical interventions, especially in patients with severe concomitant pathology, severe general condition. In this case, they can be as element (stage) of complex treatment and an independent, final method of surgical care. The choice of echo-controlled interventional technologies as a method of operational correction should be carried out with understanding their capabilities. The effectiveness of such mini-invasive methods allows us to recommend their acceptance in surgical hospitals for diseases of the abdominal cavity organs and retroperitoneal space.
THE ROLE OF THE RATIO OF TAURIN / ALANIN AS A PREDICTOR OF THE EFFICIENCY OF MEDICAMENTOUS CORRECTION OF CARDIAC RHYTHM DISORDERS IN POSTINFARCT PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Belikova J.
Published: April 2024

The aim: Determine the predictor quality of the taurine / alanine ratio (Tau / Ala) in predicting the antiarrhythmic activity of taurine (TN) and meldonium (ME) in patients with post-infarction cardiosclerosis (PIC) and diabetes mellitus type 2 (T2DM).

Materials and Methods 92 patients were examined with PICS and T2DM, which were divided into two groups: main (MG), (n = 62): 34 women and 28 men, the median age of the patients was 65.4 years (interquartile interval (II) – 61 -69 years), and the control group (CG) (n = 30): 17 women and 13 men, the median age – 64.6 years (II 64-67 years). CG patients took only basic therapy (BT) preparations of PICS and T2DM. In order to study the complex and isolated effect of TN and ME, the MG was divided into 3 subgroups (SG) in accordance with the additional treatment to BT. Amino acids and the ratios between them were determined. According to the results of Holter ECG monitoring (HECM), heart rate disorders (HRD) was evaluated.

Results: It was revealed that the effectiveness of treatment depends (p <0.05 by the Chi-square criteria) on the chosen treatment method. It was established that the combined use of TN and ME in patients SG 3 leads to a pronounced decrease in ventricular arrhythmia (VE) compared with CG (p = 0.02). There were no statistically significant differences in the effectiveness of treatment in the MG subgroups between themselves, and SG 1 and SG 2 from the CG were not detected (p = 0.49, p = 0.47 and p = 0.64, respectively). Against the background of the treatment, a significant increase in Tau / Ala in all subgroups was recorded.

Conclusion The use of ME and TN for 12 weeks in patients with PICS with T2DM has a positive effect on the HRD and AMA values of the blood spectrum. The serum Tau / Ala ratio is a highly sensitive and highly specific predictor of the response to the drug correction of HRV in patients with PICS and T2DM.
RARE COMPLICAION AFTER NEPHRON-SPARING SURGERY IN COMPLEX PT3A KIDNEY CANCER PATIENTS: A CASE REPORT
Authors: Yakovlev Pavel , Nikolaienko Sofiia , Zokhniuk Nataliia , Pasiechnikov Sergii
Published: April 2024

Benefit of partial nephrectomy compered to radical nephrectomy have shown by numerous studies as this preserves most of the functioning kidney, thus preventing onset of chronic kidney failure and potential cardio-vascular mortality. In the same time, partial nephrectomy is associated with slightly increase in the rates of post-operative complications such as perioperative bleeding and urinary fistulas which might lead to life-threatening conditions. This case shows surgery, which was performed for 39 year-old male patient with intraparenchymal kidney cancer and the postoperative course, complicated with rare vascular abnormality – renal artery-renal pelvis fistula. It demonstrates multidisciplinary oncourosurgical and endovascular approach of treating kidney cancer lesions that may provide successful organ-preserving results. The possibility of such complication in centrally localized tumors should be taken into account.
HYGIENIC ASSESSMENT OF LOW-CARBOHYDRATE DIET’S INFLUENCE ON THE NUTRITIONAL STATUS OF THE STUDENT
Authors: Herasymenko S.V. , Blagaia A.V. , Zinchenko T.I.
Published: April 2024

The effect of low-carbohydrate diets on the nutritional status of human has been studied.

The aim of the work was the hygienic assessment of the effect of low-carbohydrate diet on the student’s nutritional status.

Materials and methods. The analysis of the nutrient composition of the four diets was carried out and the dynamics of the student’s body mass over the observation period were studied.

Results. Findings indicate reduced amounts of fats and carbohydrates content in proposed diets, as well as a decrease in the level of micronutrients such as Ca, however, the amount of Mg, P, K, Fe and some vitamins were increased. The energy value of the rations was below daily needs by almost 5 times. The positive dynamics of the student’s body weight reduction for the period from 07/30/2018 to 08/22/2018 was revealed. It is determined that the fat content, incl. visceral, during the study period decreased. A decrease in chest, waist, abdomen and hips circumferences was also noted.

Conclusions. The results obtained allowed to establish that a temporary low-carbohydrate diet has a positive effect on the nutritional status of a person with an increased body mass.
MODIFICATION OF GUT BACTERIAL BILE SALT HYDROLASE ACTIVITY AND CARDIOVASCULAR RISK: A RANDOMIZED STUDY
Authors: Neverovskyi Artem , Chernyavskyi Volodymyr , Shypulin Vadim , Gvozdecka Lesya , Mikhn`ova Nataliya
Published: April 2024

Introduction: secretion of bacterial bile salt hydrolase (BSH) is one of the main mechanisms by which gut microbiota play role in cholesterol metabolism. There are limiting and controversial data regarding the clear effect of gut BSH activity correction on modification of serum cholesterol and cardiovascular risk (CVR). Aim of investigation was to evaluate the relationship between modification of the gut bacterial BSH relative activity (RA) by probiotic L. plantarum and serum cholesterol with CVR levels. Methods: the study was conducted as open, comparative, randomized, parallel and included 26 almost healthy participants (healthy control group) and 77 patients with dyslipidemia and without anamnesis of major cardiovascular events, that were divided in two groups: main treatment group (n=41) received combination therapy (capsules with Lactobacillus plantarum in the amount of 2*109 CFU one time a day and tablets simvastatin 20 mg one time a day) and control treatment group (n=36) received monotherapy (simvastatin 20 mg one time a day) during 12 weeks. Before and after 12 weeks of treatment the assessment of total RA of gut BSH, lipid profile and CVR level according to 5 risk scores were performed. Results: at baseline the RA of BSH was higher in healthy adults comparing to participants with dyslipidemia (p<0,001); after 12 weeks of treatment there wasn`t difference between healthy control and only main treatment groups (р=0,45). It was found that with increasing of RA of gut bacterial BSH, the risk of failure of treatment efficacy endpoints achievement (≥20% reduction of values) decreased regarding: total cholesterol (TC) (p=0,0306), OR=0,00133 (95% CI; 3,28*10-6-0,538); low-density lipoproteins (LDL) (p<0,001), OR=5,65*10-14(95% CI; 6,38*10-20-5*10-8); CVR level according to Framingham score (р=0,0035), OR=4,09*10-5(95% CI; 4,66*10-8-0,0359); CVR level according to 2013 ACC/AHA algorithm (р=0,0135), OR=3,8*10-4(95% CI; 7,34*10-7-0,197); CVR level according to PROCAM score (p=0,00125), OR=8,38*10-6 (95%; CI; 6,93*10-9-0,0101). Conclusions: additional supplementation with BSH-producing bacteria L. plantarum was more effective in increasing of BSH activity compared to simvastatin monotherapy. Increasing of BSH RA by L. plantarum was associated with higher chances to achieve treatment efficacy goals regarding reduction of TC, LDL and CVR levels according to Framingham, 2013 ACC/AHA algorithm and PROCAM scores.
MYSTERIOUS WAYS OF KYIV SURGERY (PART 1). UNIVERSITY HOSPITAL
Authors: Dubenko Dmytro
Published: April 2024

The article highlights the historical aspects of the development and formation of surgery in Kyiv in the 19th and 20th centuries. Based on archival documents, the chronology of the creation of St. Volodymyr Kyiv University faculty surgical hospital is shown. Some facts of the hospital's existing during the Russian Empire, the revolutionary events of 1917-1921, Soviet period and the Nazi occupation of Kyiv in 1941-1943 are described. The research presents biographical facts about the chiefs and employees of the faculty surgical hospital: Yevgen Chernyakhivsky, Yuriy Voronyi, Vira Gedroyts, Mykola Volkovych, Olexiy Lazurenko.
MENTAL HEALTH STATUS IN PATIENTS WITH STABLE CORONARY HEART DISEASE COMBINED WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: Vakalyuk I.I.
Published: April 2024

Cardio-vascular disease remains the leading cause of death and disability in the population of the world and Ukraine, in particular. There are a number of factors, that contribute to increased cardio-vascular risk. Among them, the leaders are psycho-emotional disorders that cause an increase of cardiovascular mortality and reduce the overall assessment of the life quality of these patients. The aim of the study was to assess the mental health status of the patients with stable coronary heart disease (CHD) based on the presence and progression of non-alcoholic fatty liver disease (NAFLD). 300 patients with stable CHD were observed. Among them were 160 patients without NAFLD (Group I) and 140 patients with NAFLD (Group II). Among patients of Group II persons with non-alcoholic steatosis (Group IIA) and non-alcoholic steatohepatitis (NASH) (Group IIB) were observed. Assessment of mental health status was conducted by the Ukrainian versions of Hospital Anxiety and Depression Scale (HADS) and health questionnaire PHQ-15. Analysis of the results revealed clear patterns of modifications of the patient’s mental health depending on the availability and duration of NAFLD. In particular, in patients of Group I the total share of anxiety disorders was 65%. In the case of NAFLD the prevalence of depressive mental disorders was found. However, the most important manifestations as in percentage and clinical symptoms were observed in patients with NASH. Moreover, the total assessment score of patient health increased due to progression of anxiety and depression manifestations. Thus, the mental health of the patients with stable CHD was significantly affected by availability and progression of NAFLD. In particular, the absence of NAFLD in patients with stable CHD was characterized by the presence of anxiety-depressive mental disorder with prevalence of anxiety component. In the case of combined of stable CHD and NAFLD total share of mental disorders characterized by dominance of depressive disorders, the most pronounced in patients with NASH.
Impact of changes in the vaginal microbiome and chronic endometritis on the initiation of hyperplastic processes of the endometrium in women
Authors: Khaskhachykh Dmytro, , Potapov Valentin
Published: April 2024

the article presents a review of the literature, which examines the impact of changes inthe vaginal microbiome and chronic endometritis on the development of hyperplastic processes of the

endometrium in women. Many studies have proven the undoubted role of these factors in the develop-ment of endometrial hyperplastic processes, such as atypical hyperplasia and endometrial polyposis.

Chronic endometritis, on the background of which there was a course of endometrial hyperplasia, in95.1% of women studied was caused by an infection of viral, bacterial or fungal origin. Numerous

studies indicate the important role of chronic persistent infection in the development of hyperprolif-erative processes of the endometrium. The largest role in the pathological process is probably played

by bacteria of the genus Gardnerella viridans as well as gram-positive cocci (Streptococcus). Herpes

simplex virus, cytomegalovirus, human papilloma virus and pathogenic fungi represented by the ge-nus Candida also influence the occurrence of this process. Further studies of the pathological action

of these microorganisms will achieve greater accuracy in the diagnosis of hyperplastic processes ofthe endometrium.
POTENSI ANURA DI DESA KINJIL PESISIR KABUPATEN KETAPANG SEBAGAI SUMBER BELAJAR BIOLOGI
Authors: Dilla Khastuti  , Setiadi Anandita Eka , Qurbaniah Mahwar
Published: April 2024

Desa Kinjil Pesisir terletak di pesisir pantai yang memiliki 3 tipe habitat yang disukai Anura yaitu pemukiman, perkebunan, dan persawahan. Desa Kinjil Pesisir berdekatan dengan lingkungan sekolah sehingga dapat dimanfaatkan sebagai sumber belajar. Tujuan penelitian ini adalah mengkaji potensi anura yang ada di Desa Kinjil Pesisir kabupaten Ketapang, provinsi Kalimantan Barat, untuk dimanfaatkan sebagai sumber belajar biologi. Penenelitian dilakukan melalui 2 tahapan yaitu tahap I dilakukan inventarisasi dan identifikasi jenis anura Desa Kinjil Pesisir melalui melalui metode VES (Visual Ecounter Survey), dan tahap II melalui analisis angket potensi anura sebagai sumber belajar yang diisi oleh guru Biologi SMAN 2 Ketapang, SMAN 3 Ketapang, SMAN 4 Ketapang, SMA Muhammadiyah Ketapang, dan SMA Ma’arif Ketapang. Analisis data menggunakan metode deskriptif kualitatif. Hasil penelitian tahap I menemukan 12 individu anura dari 3 spesies yang ditemukan di 3 tipe habitat berbeda di Desa Kinjil Pesisir. Hasil penelitian tahap II menunjukan bahwa anura di desa Kinjil Pesisir berpotensi sebagai sumber belajar dan sesuai dengan submateri pokok kelas X, yaitu keanekaragaman hayati, klasifikasi mahluk hidup, ekologi,dan ruang lingkup biologi.
The impact of board size and independence on trade receivables in Vietnam
Authors:   University of Economics and Law, Ho Chi Minh City, Vietnam, Nguyễn Thanh Liêm ,   Vietnam National University, Ho Chi Minh City, Vietnam, Nguyen Vy ,   University of Economics and Law, Ho Chi Minh City, Vietnam; Vietnam National University, Ho Chi Minh City, Vietnam
Published: April 2024

Trade credit plays a significant role in firm performance, and proper corporate governance can help manage trade credit in the best interest of shareholders. Given the nature of high levels of information asymmetry and inadequate institutional quality in developing countries, the role of corporate governance linked to board characteristics is highly relevant in determining the level of trade credit granted. Even though trade credit might help firms win customers, excessive trade credit extension puts the firms at risk of working capital being abused by purchasers, and low liquidity which hampers smooth operations or even bankruptcy. In a developing country like Vietnam, it is likely that boards can act as a deterrence to business practices that are harmful to corporate performance. This research paper investigates the relationship between two board characteristics and trade receivables in Vietnam using data from 2010 to 2022. The research utilizes conventional panel data estimators, including the random effects model and the System Generalized Method of Moments. We find that board size tends to reduce trade receivables, implying that larger boards prevent firms from extending much trade credit which could lead to increased implicit costs and hamper firms’ liquidity. This result implies that firms benefit more from larger boards, rather than encounter troublesome coordination caused by more crowded boards. However, board independence is insignificantly associated with trade credit extension, suggesting that this factor does not help curb trade credit extension. This result negates the view that firms benefit more from independent directors and that independent directors do not necessarily enhance corporate governance in Vietnam. Based on these results, the research offers implications for the directors monitoring role and strategy management especially in a developing country.