bluuebunny/crossref_metadata_2025 huggingface dataset:
An Attribute-Based Approach toward a Secured Smart-Home IoT Access Control and a Comparison with a Role-Based Approach
Authors: Ameer Safwa , Benson James , Sandhu Ravi
Published: January 2022

The area of smart homes is one of the most popular for deploying smart connected devices. One of the most vulnerable aspects of smart homes is access control. Recent advances in IoT have led to several access control models being developed or adapted to IoT from other domains, with few specifically designed to meet the challenges of smart homes. Most of these models use role-based access control (RBAC) or attribute-based access control (ABAC) models. As of now, it is not clear what the advantages and disadvantages of ABAC over RBAC are in general, and in the context of smart-home IoT in particular. In this paper, we introduce HABACα, an attribute-based access control model for smart-home IoT. We formally define HABACα and demonstrate its features through two use-case scenarios and a proof-of-concept implementation. Furthermore, we present an analysis of HABACα as compared to the previously published EGRBAC (extended generalized role-based access control) model for smart-home IoT by first describing approaches for constructing HABACα specification from EGRBAC and vice versa in order to compare the theoretical expressiveness power of these models, and second, analyzing HABACα and EGRBAC models against standard criteria for access control models. Our findings suggest that a hybrid model that combines both HABACα and EGRBAC capabilities may be the most suitable for smart-home IoT, and probably more generally.
A Framework for Building Comprehensive Driver Profiles
Authors: Payyanadan Rashmi P. , Angell Linda S.
Published: January 2022

Conventional approaches to modelling driver risk have incorporated measures such as driver gender, age, place of residence, vehicle model, and annual miles driven. However, in the last decade, research has shown that assessing a driver’s crash risk based on these variables does not go far enough—especially as advanced technology changes today’s vehicles, as well as the role and behavior of the driver. There is growing recognition that actual driver usage patterns and driving behavior, when it can be properly captured in modelling risk, offers higher accuracy and more individually tailored projections. However, several challenges make this difficult. These challenges include accessing the right types of data, dealing with high-dimensional data, and identifying the underlying structure of the variance in driving behavior. There is also the challenge of how to identify key variables for detecting and predicting risk, and how to combine them in predictive algorithms. This paper proposes a systematic feature extraction and selection framework for building Comprehensive Driver Profiles that serves as a foundation for driver behavior analysis and building whole driver profiles. Features are extracted from raw data using statistical feature extraction techniques, and a hybrid feature selection algorithm is used to select the best driver profile feature set based on outcomes of interest such as crash risk. It can give rise to individualized detection and prediction of risk, and can also be used to identify types of drivers who exhibit similar patterns of driving and vehicle/technology usage. The developed framework is applied to a naturalistic driving dataset—NEST, derived from the larger SHRP2 naturalistic driving study to illustrate the types of information about driver behavior that can be harnessed—as well as some of the important applications that can be derived from it.
Failure Investigation of under Construction Prestressed Concrete Bridge in Chitwan, Nepal
Authors: Adhikari Rabindra , Jha Pratyush , Bhatt Lalit , Thapa Dipesh , Forcellini Davide , Gautam Dipendra
Published: January 2022

On 6 April 2021, a 200 m-long under-construction prestressed concrete bridge failed in the Chitwan District in central Nepal. Two of the four bridge spans collapsed without any notable evidence of dynamic force application. Under-construction bridge failures are sometimes reported and can have a significant impact on the future construction adjustments. Thus, a detailed study of failure mechanisms will be insightful for the structural engineering community. Aiming to document the failure modes and exemplify lessons for improvement, this paper reports the detailed component level failure mechanisms of the bridge using visual inspection, site measurements, finite element modeling, and some forms of non-destructive testing. The chronological failure mechanisms are presented based on the field evidence and juxtaposed with the results of analytical modeling. The sum of findings highlights that the dead load failure, triggered by the settlement of falseworks, is the most critically governing factor that initiated and aggravated the damage scenario.
Impact of Rainfall-Induced Landslide Susceptibility Risk on Mountain Roadside in Northern Thailand
Authors: Dechkamfoo Chotirot , Sitthikankun Sitthikorn , Kridakorn Na Ayutthaya Thidarat , Manokeaw Sattaya , Timprae Warut , Tepweerakun Sarote , Tengtrairat Naruephorn , Aryupong Chuchoke , Jitsangiam Peerapong , Rinchumphu Damrongsak
Published: January 2022

Landslide incidents frequently occur in the upper northern region of Thailand due to its topography, which is mostly mountainous with high slopes. In the past, when landslides happened in this area, they affected traffic accessibility for rescue and evacuation. For this reason, if the risk of landslides could be evaluated, it would help in the planning of preventive measures to mitigate the damage. This study was carried out to create and develop a risk estimation model using the artificial neural network (ANN) technique for landslides at the edge of the roadside, by collecting field data on past landslides in the study areas in Chiang Rai and Chiang Mai Provinces. A total of 9602 data points were collected. The variables for forecasting were: (1) land cover, (2) physiographic features, (3) slope angle, and (4) five-day cumulative rainfall. Two hidden layers were used to create the model. The number of nodes in the first and second hidden layers were five and one, respectively, which were derived from a total of 25 trials, and the highest accuracy achieved was 96.74%. When applying the model, a graph demonstrating the relationship between the landslide risk, rainfall, and the slopes of the road areas was obtained. The results show that high slopes result in more landslides than low slopes, and that rainfall is a major trigger for landslides on roads. The outcomes of the study could be used to create risk maps and provide information for developing warnings for high-slope mountain roads in the upper northern region of Thailand.
”Unmasking the Villain”: Integrative Taxonomy Reveals the Real Identity of the Key Pest (Thysanoptera: Thripidae) of Peanuts (Arachis hypogaea L.) in South America
Authors: Lima Élison Fabrício Bezerra , Alencar Áquila Rayane Silva de , Nanini Frederico , Michelotto Marcos Doniseti , Corrêa Alberto Soares
Published: January 2022

The peanut thrips, Enneothrips enigmaticus sp. n., is the key pest of Arachis hypogaea L. in South America, where it can cause yield losses of up to 85%. This species has historically been identified as Enneothrips flavens, but access to the holotype of this species and freshly collected material from southeastern and northern Brazil revealed that specimens commonly collected on peanut crops are not conspecific with E. flavens. Biological, molecular, and morphological assessments were carried out and led to the conclusion that the key pest of A. hypogaea belongs to a previously undescribed species: Enneothrips enigmaticus sp. n.
Edible Insects as Food–Insect Welfare and Ethical Aspects from a Consumer Perspective
Authors: Delvendahl Nora , Rumpold Birgit A. , Langen Nina
Published: January 2022

A growing number of studies underline consumers’ concerns about the importance of animal welfare as a general concept for consumers’ purchase decisions. In particular, consumers perceive animal husbandry to be one of the most important aspects of animal welfare. Since intensive livestock production is criticized across society, the acceptance of current intensive production systems of edible insects is an issue of investigation. Criteria of insect welfare might differ from vertebrate welfare. One might argue that it is difficult to define standards for insect welfare due to their large diversity in living environments and feed requirements. In addition, it is debated whether insects are conscious and suffer from pain. It has been demanded to rear insects preferably under natural living conditions and some researchers proposed to consider them as sentient beings. Basic welfare and ethical aspects of insects as food and feed include species-specific mass rearing conditions and euthanasia, i.e., killing procedures. Consumers’ opinions and concerns regarding this issue have hardly been considered so far. In this paper, the animal welfare of prevalent livestock is defined and outlined, and relevant criteria are transferred to insect welfare. Different ways consumers might arrive at an animal welfare understanding are discussed, along with an overview of the few consumer studies on insect welfare. Furthermore, we consider how insects are presented in the public discourse and infer how this might be relevant to consumers’ perceptions of insect welfare.
Comparative Mitochondrial Genomics of 104 Darwin Wasps (Hymenoptera: Ichneumonidae) and Its Implication for Phylogeny
Authors: Zheng Boying , Han Yuanyuan , Yuan Ruizhong , Liu Jingxian , van Achterberg Cornelis , Tang Pu , Chen Xuexin
Published: January 2022

Ichneumonidae is one of the largest families of insects with a mega-diversity of specialized morphological and biological characteristics. We newly sequenced 92 mitochondrial genomes of ichneumonid wasps and found that they have a conserved base composition and a lower evolutionary rate than that of other families of parasitic Hymenoptera. There are 38 types of gene order in the ichneumonid mitochondrial genome, with 30 novel types identified in 104 ichneumonids. We also found that the rearrangement events occur more frequently in Ophioniformes than in Ichneumoniformes and Pimpliformes. Furthermore, the higher Ophioniformes and their relative lineages shared the transposition of trnL2 to trnI-trnQ-trnM tRNA cluster. We confirmed five higher-level groupings of Ichneumonidae: Brachycyrtiformes, Ichneumoniformes, Ophioniformes, Pimpliformes and Xoridiformes. Two formerly unplaced subfamilies, Eucerotinae and Microleptinae, were placed in Brachycyrtiformes and Ichneumoniformes, respectively. The results will improve our understanding of the diversity and evolution of Ichneumonidae.
Genetic Evidence of an Isolation Barrier between Flea Subspecies of Citellophilus tesquorum (Wagner, 1898) (Siphonaptera: Ceratophyllidae)
Authors: Ilinsky Yury , Lapshina Vasilina , Verzhutsky Dmitry , Fedorova Yulia , Medvedev Sergey
Published: January 2022

This study investigated the relationship between two subspecies of the Citellophilus tesquorum flea, C. t. altaicus and C. t. sungaris, which are vectors of the bacterium Yersinia pestis that causes human plague across the vast territories of the Palearctic. Adult fleas were collected from 16 localities and 11 populations in 2019 and 2020. Specimens were morphologically verified for subspecies status and analysed for mitochondrial cytochrome c oxidase subunit I (COI) DNA, nuclear ribosomal cluster internal transcribed spacer 1 (ITS1) and ITS2, and Wolbachia-infection status. Our results demonstrated a genetic difference between C. t. altaicus and C. t. sungaris. According to mitochondrial data, the genetic distance between clades of C. t. altaicus and C. t. sungaris was comparable with the species divergence of the genus Callopsylla, which is closely related to Citellophilus. All studied populations of C. t. altaicus were Wolbachia-infected, whereas all studied populations of C. t. sungaris were symbiont-free. Data for ITS1 and ITS2 had much lower phylogenetic signals than mitochondrial data; however, diagnostic substitutions for C. t. altaicus and C. t. sungaris delimitation were also revealed. Analysis of a hardly accessible report on cross experiments allowed us to conclude the partial postzygotic isolation between these subspecies. Taken together, the molecular-genetic, geographical, morphological, and reproductive isolation findings verified that C. t. altaicus and C. t. sungaris subspecies could be considered as different species.
Do It by Yourself: Larval Locomotion in the Black Soldier Fly Hermetia illucens, with a Novel “Self-Harvesting” Method to Separate Prepupae
Authors: Giannetti Daniele , Schifani Enrico , Reggiani Roberto , Mazzoni Emanuele , Reguzzi Maria Cristina , Castracani Cristina , Spotti Fiorenza A. , Giardina Beatrice , Mori Alessandra , Grasso Donato A.
Published: January 2022

The neotropical insect Hermetia illucens has become a cosmopolite species, and it is considered a highly promising insect in circular and sustainable economic processes. Being able to feed on a wide variety of organic substrates, it represents a source of lipids and proteins for many uses and produces recyclable waste. We investigated the characteristics and differences in the poorly-known locomotory behaviour of larvae of different instars, paying particular attention to the unique characteristics of the prepupal stage, key to farming and industrial processes. Moreover, we attempted to develop a “self-harvesting” system relying on the behavioural traits of prepupae to obtain their separation from younger larvae under rearing condition with minimum effort. Prepupae differ from younger larvae in their response to physical disturbance in the form of tonic immobility and significantly differ in their locomotory movements. Both prepupae and younger larvae reacted similarly to heat or light-induced stress, but low light and high moisture induced only prepupae to migrate away, which resulted in the development of a highly efficient separation methodology. The new data on the behaviour of H. illucens not only shed new light on some unexplored aspects of its biology, but also led to develop an inexpensive self-harvesting system that can be implemented in small-scale and industrial farming.
Sex-Specific Regulatory Systems for Dopamine Production in the Honey Bee
Authors: Sasaki Ken , Watanabe Tomohiro
Published: January 2022

Dopamine has multiple functions in the modulation of social behavior and promotion of reproduction in eusocial Hymenoptera. In the honey bee, there are sex-specific differences in the regulation of dopamine production in the brain. These different dopaminergic systems might contribute to the maintenance of sex-specific behaviors and physiology. However, it is still not fully understood how the dopaminergic system in the brain is regulated by endocrinal factors and social stimuli in the colony. In this review, we focus on the regulation of dopamine production in queens, workers, and males in the honey bee. Dopamine production can be controlled by queen substance, juvenile hormone, and exogenous tyrosine from food. Queens can control dopamine production in workers via queen substance, whereas workers can manipulate the supply of tyrosine, a precursor of dopamine, to queens and males. The regulation of dopamine production through social interaction might affect the reproductive states of colony members and maintain sex-specific behaviors in unpredictable environments.
Behavior of Nymphs and Adults of the Black-Legged Tick Ixodes scapularis and the Lone Star Tick Ambylomma americanum in Response to Thermal Stimuli
Authors: Otálora-Luna Fernando , Dickens Joseph C. , Brinkerhoff Jory , Li Andrew Y.
Published: January 2022

Ticks use chemical and thermal signals emitted by humans and other vertebrates to locate suitable hosts for a blood meal. Here, we study the behavior of black-legged Ixodes scapularis and the lone star ticks Amblyomma americanum exposed to heat sources held at temperatures near those of vertebrate hosts (32 °C). First, we used a locomotion compensator to test behavioral responses of ticks to an infrared light emitting diode (LED). The servosphere allowed us to measure parameters such as velocity, acceleration, linearity, and orientation. Then a heating element (Peltier) located in one of the extremes of a double-choice vertical rod (flying T), was employed to observe upward movement of the ticks toward such a heat source. While both species oriented toward the LED, only lone star ticks were attracted to the Peltier element while climbing upward. In conclusion, we showed that heat attracted ticks from short distances up to several centimeters on a the servosphere, and those responses differed between the two species of ticks on the flying T. We discuss our results in the context of the ecology of both tick species and their potential in tick survey and management.
Male Accessory Glands of Blister Beetles and Cantharidin Release: A Comparative Ultrastructural Analysis
Authors: Muzzi Maurizio , Mancini Emiliano , Fratini Emiliano , Cervelli Manuela , Gasperi Tecla , Mariottini Paolo , Persichini Tiziana , Bologna Marco Alberto , Di Giulio Andrea
Published: January 2022

Members of the family Meloidae are known to produce cantharidin, a highly toxic monoterpene found in their hemolymph and exuded as droplets capable of deterring many predators. As a nuptial gift, males transfer large amounts of cantharidin to females via a spermatophore, which is formed by specific accessory glands containing high concentrations of this terpene. Using light, electron and ion beam microscopy, the ultrastructural features of the three pairs of male accessory glands as well as the glandular part of the vasa deferentia were comparatively investigated in seven species of blister beetles belonging to five different tribes and two subfamilies. All gland pairs examined share common features such as mesodermal derivation, the presence of muscle sheath, a developed rough endoplasmic reticulum, abundant mitochondria, secretory vesicles, and microvillated apical membranes. Within the same species, glands exhibit distinctive features, suggesting that each pair is responsible for the formation of a specific substance. The vasa deferentia, while showing many similarities within the family, often exhibit features unique to each of the individual species investigated, whereas the accessory glands of the first and second pairs display the highest degree of ultrastructural variability. A comparison across the species shows an interesting constancy limited to ultrastructural features in the third pair of accessory glands. The similarities and differences among the species are discussed in the light of the available literature and in relation to the potential role that blister beetles’ male accessory glands could play in the storage and management of cantharidin.
Acknowledgment to Reviewers of Inventions in 2021
Authors:   Inventions Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Photocatalytic H2 Production on Au/TiO2: Effect of Au Photodeposition on Different TiO2 Crystalline Phases
Authors: Balsamo Stefano Andrea , Sciré Salvatore , Condorelli Marcello , Fiorenza Roberto
Published: January 2022

In this work, we investigated the role of the crystalline phases of titanium dioxide in the solar photocatalytic H2 production by the reforming of glycerol, focusing the attention on the influence of photodeposited gold, as a metal co-catalyst, on TiO2 surface. We correlated the photocatalytic activity of 1 wt% Au/TiO2 in anatase, rutile, and brookite phases with the structural and optical properties determined by Raman spectroscopy, N2 adsorption–desorption measurements, UV–vis Diffuse Reflectance Spectroscopy (UV–vis DRS), X-ray photoelectron spectroscopy (XPS), Photoluminescence spectroscopy (PL), and Dynamic Light scattering (DLS). The best results (2.55 mmol H2 gcat−1 h−1) were obtained with anatase and gold photodeposited after 30 min of solar irradiation. The good performance of Au/TiO2 in anatase form and the key importance of the strong interaction between gold and the peculiar crystalline phase of TiO2 can be a starting point to efficiently improve photocatalysts design and experimental conditions, in order to favor a green hydrogen production through solar photocatalysis.
Tachyarrhythmias in Congenital Heart Diseases: From Ion Channels to Catheter Ablation
Authors: Waldmann Victor , Guichard Jean-Baptiste , Marijon Eloi , Khairy Paul
Published: January 2022

Major advances in pediatric cardiology in recent decades, especially surgical techniques, have resulted in an increasing number of patients with congenital heart disease (CHD) surviving to adulthood. This has generated new challenges, particularly with regards to the late onset of complex arrhythmias. Abnormal anatomy, surgical scarring, chronic hypoxemia, hemodynamic compromise, neuro-hormonal abnormalities, and genetic factors can all contribute to creating a unique substrate for arrhythmia development. This review attempts to synthesize the current state of knowledge spanning the spectrum from underlying mechanisms of arrhythmias in patients with congenital heart disease to current ablative strategies. We discuss existing knowledge gaps and highlight important areas for future research.
Early Investigational and Experimental Therapeutics for the Treatment of Hypertriglyceridemia
Authors: Parthymos Ioannis , Kostapanos Michael S. , Liamis George , Florentin Matilda
Published: January 2022

Hypertriglyceridemia has been identified as a risk factor for cardiovascular disease and acute pancreatitis. To date, there are only few drug classes targeting triglyceride levels such as fibrates and ω-3 fatty acids. These agents are at times insufficient to address very high triglycerides and the residual cardiovascular risk in patients with mixed dyslipidemia. To address this unmet clinical need, novel triglyceride-lowering agents have been in different phases of early clinical development. In this review, the latest and experimental therapies for the management of hypertriglyceridemia are presented. Specifically, ongoing trials evaluating novel apolipoprotein C-III inhibitors, ω-3 fatty acids, as well as fibroblast growth 21 analogues are discussed.
Is Long COVID a State of Systemic Pericyte Disarray?
Authors: Jones Olcay Y. , Yeralan Sencer
Published: January 2022

The most challenging aspect of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) or Long COVID remains for the discordance between the viral damage from acute infection in the recent past and susceptibility of Long COVID without clear evidence of post infectious inflammation or autoimmune reactions. In this communication we propose that disarray of pericytes plays a central role in emerge of Long COVID. We assume pericytes are agents with “Triple-A” qualities, i.e., analyze-adapt and advance, necessary for sustainability of host homeostasis. Based on this view, we further suggest Long COVID may provide a model system to integrate system theory and complex adaptive systems to explore a new class of maladies those are currently not well defined and with no remedies.
A Microplate-Based Approach to Map Interactions between TDP-43 and α-Synuclein
Authors: Jamerlan Angelo M. , An Seong Soo A.
Published: January 2022

Trans-active response DNA-binding protein (TDP-43) is a multifunctional regulatory protein, whose abnormal deposition in neurons was linked to debilitating neurodegenerative diseases, such as amyotrophic lateral sclerosis, frontotemporal lobar degeneration, Limbic-predominant age-related TDP-43 encephalopathy, and Alzheimer’s disease with a secondary pathology. Several reports showed that TDP-43 proteinopathy as a comorbidity can form aggregates with other pathological proteins. The co-deposition of alpha synuclein and TDP-43 inclusions was previously reported in glial cells and by observing TDP-43 proteinopathy in Lewy body disease. In this study, it was hypothesized that alpha synuclein and TDP-43 may co-aggregate, resulting in comorbid synucleinopathy and TDP-43 proteinopathy. A solid-phase microplate-based immunoassay was used to map out the epitopes of anti-TDP-43 antibodies and locate the interaction of TDP-43 with α-synuclein. A region of the low complexity domain of TDP-43 (aa 311–314) was shown to interact with full-length α-synuclein. Conversely, full-length TDP-43 was shown to bind to the non-amyloid beta component of α-synuclein. Using in silico sequence-based prediction, the affinity and dissociation constant of full-length TDP-43 and α-synuclein were calculated to be −10.83 kcal/mol and 1.13 × 10−8, respectively. Taken together, this microplate-based method is convenient, economical, and rapid in locating antibody epitopes as well as interaction sites of two proteins.
Mental Health Status of People with Multiple Sclerosis during the COVID-19 Pandemic
Authors: Wilski Maciej , Koper Magdalena , Gabryelski Jarosław , Brola Waldemar , Tasiemski Tomasz
Published: January 2022

Objective. This study assesses and compares the mental health status of people with multiple sclerosis (PwMS) in Poland during the second wave of the Coronavirus Disease 2019 (COVID-19) pandemic (November 2020) to a similar group whose mental health status was examined in November 2017. It also analyzed the psychological resources such as self-efficacy and health locus of control (HLC) and their relationship to mental health in both groups. Methods. Cross-sectional study included two groups of PwMS with 113 respondents each. The respondents completed the General Health Questionnaire-12 and questionnaires for assessing self-efficacy and HLC. The clinical and demographic data of participants were also collected. Results. No differences in mental health status were observed between the studied groups. A hierarchical regression model of the group studied in 2020 revealed that general self-efficacy (β = −0.21, p = 0.032), HLC—internal (β = −0.21, p = 0.035), and education (β = −0.18, p = 0.048) explained 18% of the variance in the mental health of PwMS, whereas according to the model of the group assessed in 2017 self-efficacy (β = –0.31, p < 0.001), HLC—chance (β = 0.45, p < 0.001), and HLC—internal (β = −0.37, p < 0.001) explained 48% of the variance. Conclusions. Study results suggest that the pandemic and the related lockdown had no effect on the mental health status of PwMS. At the same time, it was noted that well known determinants of mental health such as self-efficacy and HLC seemed to retain their prominent role for mental functioning in the pandemic.
Research into the Association of Cadmium and Manganese Excretion with Thyroid Function and Behavioral Areas in Adolescents with Autism Spectrum Disorders
Authors: Błażewicz Anna , Grywalska Ewelina , Macek Paweł , Mertowska Paulina , Mertowski Sebastian , Wojnicka Julia , Durante Nicolo , Makarewicz Agata
Published: January 2022

Thyroid dysfunction and toxic metal exposure have been linked to the increased risk of autism spectrum disorders (ASD); however, the relationship between those factors remains unclear. We aimed to evaluate the relationship between the serum level of hormones, namely thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and urinary cadmium (U-Cd) and urinary manganese (U-Mn), in patients with ASD. The study group consisted of 129 adolescents with ASD, and the control group consisted of 86 healthy persons. Ion chromatography with spectrophotometric detection (IC-UV/ViS) was used to quantitatively determine Cd and Mn in all 24-h urine samples. These results indicate that severity of certain symptoms in autism is associated with thyroid function. Correlation analysis between Childhood Autism Rating Scale (CARS) results and the content of both U-Mn and U-Cd as well as fT3, fT4 and TSH values in ASD patients showed significantly positive correlation of CARS7 (visual reaction) with fT3 and fT4 and a negative correlation with TSH for the whole study group. In the group of adolescents over 14 years of age, it was also observed that CARS10 (anxiety reaction) negatively correlates with serum TSH levels, and among younger individuals, CARS9 (near receptor responsiveness, taste, smell) positively correlates with TSH.
Hypophosphatemia on ICU Admission Is Associated with an Increased Length of Stay in the ICU and Time under Mechanical Ventilation
Authors: Wozniak Hannah , Dos Santos Rocha André , Beckmann Tal Sarah , Larpin Christophe , Buetti Niccolò , Quintard Hervé , Pugin Jérôme , Heidegger Claudia Paula
Published: January 2022

Hypophosphatemia is frequently observed in the ICU and is associated with several impairments such as respiratory failure or infections. We hypothesized that hypophosphatemia on ICU admission is associated with a prolonged duration of mechanical ventilation and ICU length of stay (LOS), particularly in COVID-19 patients. This cross-sectional study analyzed data from 1226 patients hospitalized in the ICU of the Geneva University Hospitals from August 2020 to April 2021. Patients were categorized as having hypophosphatemia (phosphatemia ≤ 0.8 mmol/L) or non-hypophosphatemia (phosphatemia > 0.8 mmol/L) on ICU admission. Linear regressions were performed to investigate the association between hypophosphatemia on ICU admission and ICU LOS and duration of mechanical ventilation. Overall, 250 (20%) patients presented hypophosphatemia on ICU admission. In the univariable analysis, hypophosphatemic patients had longer ICU LOS than non-hypophosphatemic patients, 7.4 days (±10.4) versus 5.6 days (±8.3), (p < 0.01). Hypophosphatemia on ICU admission was associated with a prolonged duration of mechanical ventilation, 7.4 days (±11.2) versus 5.6 days (±8.9), (p < 0.01). These associations were confirmed in the multivariable analysis (p < 0.01). In the subgroup of COVID-19 patients, a significant association between hypophosphatemia and ICU LOS and duration of mechanical ventilation was also observed. In conclusion, hypophosphatemia on ICU admission is associated with a longer ICU LOS and time under mechanical ventilation, both in the general ICU population and in COVID-19 patients.
Pitch Discrimination Testing in Patients with a Voice Disorder
Authors: Nguyen Duy Duong , Chacon Antonia M. , Novakovic Daniel , Hodges Nicola J. , Carding Paul N. , Madill Catherine
Published: January 2022

Auditory perception plays an important role in voice control. Pitch discrimination (PD) is a key index of auditory perception and is influenced by a variety of factors. Little is known about the potential effects of voice disorders on PD and whether PD testing can differentiate people with and without a voice disorder. We thus evaluated PD in a voice-disordered group (n = 71) and a non-voice-disordered control group (n = 80). The voice disorders included muscle tension dysphonia and neurological voice disorders and all participants underwent PD testing as part of a comprehensive voice assessment. Percentage of accurate responses and PD threshold were compared across groups. The PD percentage accuracy was significantly lower in the voice-disordered group than the control group, irrespective of musical background. Participants with voice disorders also required a larger PD threshold to correctly discriminate pitch differences. The mean PD threshold significantly discriminated the voice-disordered groups from the control group. These results have implications for the voice control and pathogenesis of voice disorders. They support the inclusion of PD testing during comprehensive voice assessment and throughout the treatment process for patients with voice disorders.
Retrospective Analysis of Sterile Corneal Infiltrates in Patients with Keratoconus after Cross-Linking Procedure
Authors: Krok Magdalena , Wróblewska-Czajka Ewa , Kokot Joanna , Micińska Anna , Wylęgała Edward , Dobrowolski Dariusz
Published: January 2022

Background: This paper’s objective is to analyze patients with keratoconus who developed sterile infiltrate after corneal collagen cross-linking (CXL), and to evaluate possible risk factors for their occurrence. Methods: 543 medical histories of patients after cross-linking (Epi-off, Epi-on) procedure performed according to the Dresden protocol were analyzed retrospectively. Results: Sterile corneal infiltrates occurred in four men (0.7%) in the age range (16–28) years, the average age being 20.3. The average time from procedure to onset of symptoms was 3.5 days (2–5 days). Inflammatory infiltration resolved in all patients, leaving scars on corneal stroma in two patients. Corneal healing time ranged from 4–12 weeks. In vivo confocal microscopy (IVCM), round inflammatory cells, and Langerhans cells in the epithelium and Bowman’s layer were observed at the site of infiltration. The Optical coherence tomography (OCT) shows hyperreflective lesions of various sizes which decreased over time. The corneal topographic parameters and Best-corrected visual acuity (BCVA) improved after the CXL procedure in all of the described cases. Conclusions: Most likely, damage to the epithelium and the phototoxic effect of the procedure is of significant importance in the formation of sterile corneal infiltrates. Appropriate classification and selection of CXL procedures in combination with protective measures in people at risk may have an overwhelming impact on the incidence of this complication.
Associated Factors of High Sedative Requirements within Patients with Moderate to Severe COVID-19 ARDS
Authors: Flinspach Armin N. , Booke Hendrik , Zacharowski Kai , Balaban Ümniye , Herrmann Eva , Adam Elisabeth H.
Published: January 2022

The coronavirus pandemic continues to challenge global healthcare. Severely affected patients are often in need of high doses of analgesics and sedatives. The latter was studied in critically ill coronavirus disease 2019 (COVID-19) patients in this prospective monocentric analysis. COVID-19 acute respiratory distress syndrome (ARDS) patients admitted between 1 April and 1 December 2020 were enrolled in the study. A statistical analysis of impeded sedation using mixed-effect linear regression models was performed. Overall, 114 patients were enrolled, requiring unusual high levels of sedatives. During 67.9% of the observation period, a combination of sedatives was required in addition to continuous analgesia. During ARDS therapy, 85.1% (n = 97) underwent prone positioning. Veno-venous extracorporeal membrane oxygenation (vv-ECMO) was required in 20.2% (n = 23) of all patients. vv-ECMO patients showed significantly higher sedation needs (p < 0.001). Patients with hepatic (p = 0.01) or renal (p = 0.01) dysfunction showed significantly lower sedation requirements. Except for patient age (p = 0.01), we could not find any significant influence of pre-existing conditions. Age, vv-ECMO therapy and additional organ failure could be demonstrated as factors influencing sedation needs. Young patients and those receiving vv-ECMO usually require increased sedation for intensive care therapy. However, further studies are needed to elucidate the causes and mechanisms of impeded sedation.
Painful Temporomandibular Disorders, Bruxism and Oral Parafunctions before and during the COVID-19 Pandemic Era: A Sex Comparison among Dental Patients
Authors: Winocur-Arias Orit , Winocur Efraim , Shalev-Antsel Tamar , Reiter Shoshana , Shifra Levartovsky , Emodi-Perlman Alona , Friedman-Rubin Pessia
Published: January 2022

Aim: To evaluate the effect of the current coronavirus pandemic on the prevalence of bruxism, oral parafunctions and painful Temporo-Mandibular Disorders (TMDs) and to evaluate the influence of the pandemic on both sexes. Methods: This retrospective study included 288 dental patients who underwent complete anamnesis and examination according to the Diagnostic Criteria for TMD. The study evaluated two patient populations according to the date of examination: (a) pre-COVID-19 pandemic era (108 patients); (b) COVID 19 pandemic era, where 180 patients were examined during the pandemic. Results: A significant increase in parafunction activity was found in both men and women (p < 0.001) during the COVID-19 pandemic. Awake bruxism (AB) and sleep bruxism (SB) was more prevalent during the COVID-19 pandemic solely in women (AB-p < 0.001; SB-p = 0.014). Conclusions: Men and women were affected by the ongoing stress due to the COVID-19 pandemic, yet women showed a higher influence as compared to men. The long-term exposure to elevated levels of anxiety and stress may aggravate or trigger stomatognathic detrimental conditions. Dentists should be aware and regularly monitor their patients regarding the possible existence and consequences of bruxism and TMD.
Reactive and Regulative Temperament in Relation to Clinical Symptomatology and Personality Disorders in Patients with a Substance Use Disorder
Authors: Santens Els , Dom Geert , Dierckx Eva , Claes Laurence
Published: January 2022

Temperament and personality traits are important factors underlying the vulnerability for both the initiation and continuation of addictive behaviors. We investigated the influence of reactive and regulative temperament and their interaction in relation to clinical symptomatology and personality disorders (PDs) in a sample of 841 inpatients (68.1% males) with a substance use disorder (SUD). To assess reactive temperament we used the Behavioral Inhibition and Behavioral Activation Scales (BISBAS) and to assess regulative temperament we used the Effortful Control Scale. Clinical symptomatology and personality traits were measured by means of the Symptom Checklist-90 (SCL-90) and the Assessment of ADP-IV Personality Disorders (ADP-IV). Hierarchical regression analyses showed that both, clinical symptomatology and PDs were related to low levels of effortful control (EC). None of the two-way interactions (BIS × EC, BAS × EC) however were significantly related to psychopathology. Current findings highlight the role of effortful control (EC) in the expression of psychopathology in an adult sample of inpatients with SUD. Therapeutic interventions aiming at strengthening EC can possibly result in better treatment outcomes for both the addiction and the comorbid psychopathology.
Why Do These Microbes Like Me and How Could There Be a Link with Cardiovascular Risk Factors?
Authors: Sawicka-Śmiarowska Emilia , Moniuszko-Malinowska Anna , Kamiński Karol Adam
Published: January 2022

Cardiovascular diseases are the most common causes of hospitalization, death, and disability in Europe. Due to high prevalence and ensuing clinical complications, they lead to very high social and economic costs. Despite the knowledge of classical cardiovascular risk factors, there is an urgent need for discovering new factors that may play a role in the development of cardiovascular diseases or potentially influence prognosis. Recently, particular attention has been drawn to the endogenous microflora of the human body, mostly those inhabiting the digestive system. It has been shown that bacteria, along with their host cells, create an interactive ecosystem of interdependencies and relationships. This interplay could influence both the metabolic homeostasis and the immune processes of the host, hence leading to cardiovascular disease development. In this review, we attempt to describe, in the context of cardiovascular risk factors, why particular microbes occur in individuals and how they might influence the host’s cardiovascular system in health and disease.
Nutritional Influences on Locomotive Syndrome
Authors: Ito Sadayuki , Nakashima Hiroaki , Ando Kei , Machino Masaaki , Seki Taisuke , Ishizuka Shinya , Takegami Yasuhiko , Wakai Kenji , Hasegawa Yukiharu , Imagama Shiro
Published: January 2022

Healthy dietary habits are important to prevent locomotive syndrome (LS). We investigated the relationship between LS and nutritional intake using community health checkup data. We included 368 participants who underwent LS staging, blood sampling, and nutritional intake assessments. Participants (163 adults < 65: 205 older adults ≥ 65) were divided into normal (N; LS stage 0) and LS (L; LS stage 1–2) groups, and blood sample data and nutritional intake were compared between groups. Among adults (N group, 71; L group, 92), low-density lipoprotein cholesterol (LDL-C) was significantly lower, and Vitamin B1 intake was significantly higher in the L than in the N group; LDL-C, p = 0.033; Vitamin B1, 0.029. Among older adults (N group, 85; L group, 120), hemoglobin (Hb), albumin, and calcium levels were significantly lower, and sodium, monounsaturated fatty acids (MUFA), and n-6 polyunsaturated fatty acids (n-6 PUFA) were significantly higher in the L than the N group; Hb, p = 0.036; albumin, 0.030; calcium, 0.025; sodium; 0.029; MUFA; 0.047, n-6 PUFA; 0.0233). Logistic regression analysis indicated that sodium was the risk factor for the L group (exp (B) 1.001, 95% CI: 1–1.001, p = 0.032). In conclusion, salt intake was associated with LS.
Temporary Right-Ventricular Assist Devices: A Systematic Review
Authors: Abdelshafy Mahmoud , Caliskan Kadir , Guven Goksel , Elkoumy Ahmed , Elsherbini Hagar , Elzomor Hesham , Tenekecioglu Erhan , Akin Sakir , Soliman Osama
Published: January 2022

Acute right-sided heart failure (RHF) is a complex clinical syndrome, with a wide range of clinical presentations, associated with increased mortality and morbidity, but about which there is a scarcity of evidence-based literature. A temporary right-ventricular assist device (t-RVAD) is a potential treatment option for selected patients with severe right-ventricular dysfunction as a bridge-to-recovery or as a permanent solution. We sought to conduct a systematic review to determine the safety and efficacy of t-RVAD implantation. Thirty-one studies met the inclusion criteria, from which data were extracted. Successful t-RVAD weaning ranged between 23% and 100%. Moreover, 30-day survival post-temporary RAVD implantation ranged from 46% to 100%. Bleeding, acute kidney injury, stroke, and device malfunction were the most commonly reported complications. Notwithstanding this, t-RVAD is a lifesaving option for patients with severe RHF, but the evidence stems from small non-randomized heterogeneous studies utilizing a variety of devices. Both the etiology of RHF and time of intervention might play a major role in determining the t-RVAD outcome. Standardized endpoints definitions, design and methodology for t-RVAD trials is needed. Furthermore, efforts should continue in improving the technology as well as improving the timely provision of a t-RVAD.
Radiomics in Triple Negative Breast Cancer: New Horizons in an Aggressive Subtype of the Disease
Authors: Mireștean Camil Ciprian , Volovăț Constantin , Iancu Roxana Irina , Iancu Dragoș Petru Teodor
Published: January 2022

In the last decade, the analysis of the medical images has evolved significantly, applications and tools capable to extract quantitative characteristics of the images beyond the discrimination capacity of the investigator’s eye being developed. The applications of this new research field, called radiomics, presented an exponential growth with direct implications in the diagnosis and prediction of response to therapy. Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with a severe prognosis, despite the aggressive multimodal treatments applied according to the guidelines. Radiomics has already proven the ability to differentiate TNBC from fibroadenoma. Radiomics features extracted from digital mammography may also distinguish between TNBC and non-TNBC. Recent research has identified three distinct subtypes of TNBC using IRM breast images voxel-level radiomics features (size/shape related features, texture features, sharpness). The correlation of these TNBC subtypes with the clinical response to neoadjuvant therapy may lead to the identification of biomarkers in order to guide the clinical decision. Furthermore, the variation of some radiomics features in the neoadjuvant settings provides a tool for the rapid evaluation of treatment efficacy. The association of radiomics features with already identified biomarkers can generate complex predictive and prognostic models. Standardization of image acquisition and also of radiomics feature extraction is required to validate this method in clinical practice.
The Rationale and Current Status of Endotoxin Adsorption in the Treatment of Septic Shock
Authors: Śmiechowicz Jakub
Published: January 2022

Lipopolysaccharide, the main component of the outer membrane of Gram-negative bacteria is a highly potent endotoxin responsible for organ dysfunction in sepsis. It is present in the blood stream not only in Gram-negative infections, but also in Gram-positive and fungal infections, presumably due to sepsis-related disruption of the intestinal barrier. Various pathways, both extra- and intracellular, are involved in sensing endotoxin and non-canonical activation of caspase-mediated pyroptosis is considered to have a major role in sepsis pathophysiology. Endotoxin induces specific pathological alterations in several organs, which contributes to poor outcomes. The adverse consequences of endotoxin in the circulation support the use of anti-endotoxin therapies, yet more than 30 years of experience with endotoxin adsorption therapies have not provided clear evidence in favor of this treatment modality. The results of small studies support timely endotoxin removal guided by measuring the levels of endotoxin; unfortunately, this has not been proven in large, randomized studies. The presence of endotoxemia can be demonstrated in the majority of patients with COVID-19, yet only case reports and case series describing the effects of endotoxin removal in these patients have been published to date. The place of blood purification therapies in the treatment of septic shock has not yet been determined.
Association of Electrocardiographic Signs of Right Ventricular Hypertrophy and Clot Localization in Chronic Thromboembolic Pulmonary Hypertension
Authors: Sławek-Szmyt Sylwia , Araszkiewicz Aleksander , Jankiewicz Stanisław , Smukowska-Gorynia Anna , Grygier Marek , Janus Magdalena , Lesiak Maciej , Mularek-Kubzdela Tatiana
Published: January 2022

The role of electrocardiography (ECG) in chronic thromboembolic pulmonary hypertension (CTEPH) diagnosis and prognosticating has not been yet established. We aimed to assess the relationships of the recommended ECG criteria of right ventricular hypertrophy (RVH) with clot localization in CTEPH patients. ECG patterns of RVH according to the American College of Cardiology Foundation were assessed in patients with newly diagnosed CTEPH. We enrolled 58 (45.3%) patients with proximal and 70 (54.7%) with distal CTEPH. Receiver-operating characteristics curves analysis indicated that the following ECG abnormalities predicted proximal CTEPH localization: RV1 > 6 mm—AUC 0.75 (CI: 0.66–0.84, p < 0.00001); SV6 > 3 mm—AUC 0.70 (CI: 0.60–0.79, p < 0.00001); SI > RI wave—AUC 0.67 (CI: 0.58–0.77, p = 0.0004); RV1:SV1 > 1.0—AUC 0.66 (CI: 0.56–0.76, p = 0.0009); RV1 peak > 0.035 s (QRS < 120 ms)—AUC 0.66 (CI: 0.56–0.75, p = 0.0016); RV1:SV1 > RV3(V4):SV3(V4)—AUC-0.65 (CI: 0.54–0.75, p = 0.0081); RaVR > 4 mm—AUC 0.62 (CI: 0.52–0.71, p = 0.002) and PII > 2.5 mm—AUC 0.62 (CI: 0.52–0.72, p = 0.00162). Pulmonary vascular resistance significantly correlated with amplitudes of RV1 (r = 0.34, p = 0.008), SV6 (r = 0.53, p = 0.000027) and PII (r = 0.44, p = 0.00007). In patients with CTEPH, only 8 out of 23 ECG RVH criteria were useful for differentiating between proximal and distal CTEPH localization and we found that RV1 and SV6 may contribute as potential discriminators.