bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting glypican-3 expression in hepatocellular carcinoma: A comprehensive analysis using combined contrast-enhanced ultrasound and clinical factors
Authors: Li Nana , Dong Tiantian , Wang Peihua , Li Qi , Nie Fang
Published: August 2023

OBJECTIVE: Glypican-3 (GPC3) has emerged as a significant marker for the diagnosis and prognosis of hepatocellular carcinoma (HCC) and has garnered considerable attention as an immunotherapeutic target. In this study, we propose a combination of preoperative contrast-enhanced ultrasound (CEUS) imaging features and clinical factors to predict the positive expression of GPC3 in HCC patients. METHODS: We retrospectively included 30 cases of GPC3-negative HCC and 115 cases of GPC3-positive HCC patients who underwent conventional ultrasound and CEUS evaluation. We assessed and compared the clinical characteristics, conventional ultrasound features, and CEUS features between the two groups of HCC patients. Based on the clinical and ultrasound features between the two groups, we developed a binary logistic regression model for predicting GPC3-positive HCC. RESULTS: A total of 145 HCC patients were included in this study. Binary logistic regression analysis showed that AFP > 20 ng/mL (OR = 4.047; 95% CI: 1.467-11.16; p = 0.007), arterial phase hyperenhancement (APHE) (OR = 12.557; 95% CI: 3.608-43.706; p < 0.001), and asynchronous perfusion (OR = 4.209; 95% CI: 1.206-14.691; p = 0.024) were predictive factors for GPC3-positive HCC. Receiver operating characteristic (ROC) analysis was conducted to predict GPC3-positive expression. The model combining the three independent predictive factors showed good predictive performance (AUC 0.817, 95% CI: 0.731-0.902, sensitivity: 91.3%, specificity: 60.0%). This combined model demonstrated excellent discriminatory ability to predict GPC3-positive HCC. CONCLUSION: Preoperative integration of CEUS features and clinical factors can non-invasively and effectively identify GPC3-positive HCC patients, providing valuable assistance in making personalized treatment decisions.
In vitro simulation of the liver first-pass effect with biotransformation-competent HepG2 cells to study effects of MG-132 on liver and cancer cells
Authors: Kammerer Sarah , Nowak Elisabeth , Mantke René , Jung Friedrich , Küpper Jan-Heiner
Published: August 2023

BACKGROUND: Liver biotransformation is the major route for drug metabolism in humans, often catalysed by cytochrome P450 (CYP) enzymes. This first-pass effect can lead to hepatotoxicity and influences the bioavailability of drugs. OBJECTIVE: We aimed to establish in vitro culture systems simulating the liver first-pass to study effects of the proteasome inhibitor MG-132 simultaneously on hepatocytes and cancer cells. METHODS: The first-pass effect was simulated by conditioned medium transfer (CMT) from pre-treated HepG2 CYP3A4-overexpressing cells to either pancreatic cancer cell line PANC-1 or primary colon cancer cells, and by indirect co-culture (CC) of liver and cancer cells in a shared medium compartment. Experimental proteasome inhibitor MG-132 was used as test substance as it is detoxified by CYP3A4. RESULTS: Cancer cells showed higher viabilities in the first-pass simulation by CMT and CC formats when compared to monocultures indicating effective detoxification of MG-132 by HepG2 CYP3A4-overexpressing cells. HepG2-CYP3A4 cells showed reduced viabilites after treatment with MG-132. CONCLUSIONS: We successfully established two different culture systems to simulate the liver first-pass effect in vitro. Such systems easily allow to study drug effects simultaneously on liver and on target cancer cells. They are of great value in pre-clinical cancer research, pharmaceutical research and drug development.
A methodological reckoning for the empirical study of sex doll and sex robot issues
Authors: Hanson Kenneth R.
Published: August 2023

In light of repeated calls for empirically driven analyses of sex doll and sex robot owners and users, I outline key methodological challenges researchers in this field currently face. I discuss how methodological limitations have shaped the field thus far and narrowed the scope of empirical research to date. To resolve these issues, I propose strategies for improving archival, quantitative, and qualitative approaches for future scholarship. Specifically, I attend to issues of historicity, nomenclature, population, sampling, qualitative approaches, and research ethics. I conclude with a discussion of how the stigma associated with sex dolls, sex robots, and sex tech amplifies the need for researchers to respect and adhere to ethical research practices yet still maintain a critical distance that directly confronts, rather than skirts, dilemmas related to use, ownership, and production. This methodological reckoning will help scholars design more robust studies and effectively evaluate innovations in the field.
The Moderating Role of Race and Ethnicity in the Association Between Cognitive Performance and Functional Abilities in Later Life
Authors: Alam Rifat B. , Rahman Abir , Aguiñaga Susan , Schwingel Andiara
Published: August 2023

This study examined ethnic/racial influences on the relationship of cognitive performance and functional abilities of 2,713 older individuals from the National Health and Nutrition Examination Survey (NHANES). Functional domains included activities of daily living (ADL), instrumental ADL, and leisure and social activities. In adjusted logistic regression models, low cognitive performance as assessed by the Digit Symbol Substitution Test was found significantly associated with functional limitation in each domain. However, moderation analysis revealed that being Hispanic and non-Hispanic Black may weaken this association demonstrating protective effects of underrepresented ethnic/racial status. Future studies should investigate perceived discrimination and resilience.
Evaluation of Efficacy and Safety Using Low Dose Radiation Therapy with Alzheimer’s Disease: A Protocol for Multicenter Phase II Clinical Trial
Authors: Kim Dong-Yun , Kim Jae Sik , Seo Young-Seok , Park Woo-Yoon , Kim Byoung Hyuck , Hong Eun-Hee , Kim Ji Young , Cho Seong-Jun , Rhee Hak Young , Kim Aryun , Kim Keun You , Oh Dae Jong , Chung Weon Kuu
Published: August 2023

Background:

Alzheimer’s disease (AD), the most common cause of dementia, is a neurodegenerative disease resulting from extracellular and intracellular deposits of amyloid-β (Aβ) and neurofibrillary tangles in the brain. Although many clinical studies evaluating pharmacological approaches have been conducted, most have shown disappointing results; thus, innovative strategies other than drugs have been actively attempted.

Objective:

This study aims to explore low-dose radiation therapy (LDRT) for the treatment of patients with AD based on preclinical evidence, case reports, and a small pilot trial in humans.

Methods:

This study is a phase II, multicenter, prospective, single-blinded, randomized controlled trial that will evaluate the efficacy and safety of LDRT to the whole brain using a linear accelerator in patients with mild AD. Sixty participants will be randomly assigned to three groups: experimental I (24 cGy/6 fractions), experimental II (300 cGy/6 fractions), or sham RT group (0 cGy/6 fractions). During LDRT and follow-up visits after LDRT, possible adverse events will be assessed by the physician’s interview and neurological examinations. Furthermore, the effectiveness of LDRT will be measured using neurocognitive function tests and imaging tools at 6 and 12 months after LDRT. We will also monitor the alterations in cytokines, Aβ42/Aβ40 ratio, and tau levels in plasma. Our primary endpoint is the change in cognitive function test scores estimated by the Alzheimer’s Disease Assessment Scale-Korea compared to baseline after 6 months of LDRT.

Conclusions:

This study is registered at ClinicalTrials.gov [NCT05635968] and is currently recruiting patients. This study will provide evidence that LDRT is a new treatment strategy for AD.
Differences in the Cognitive Function of Mexican Adults Aged 60 and Older with Self-Reported Diabetes in 2001 and 2018
Authors: Camarillo Joe , Villarreal Rizzo Alan , Cabrero Castro Jose Eduardo , Downer Brian
Published: August 2023

Background:

The prevalence of type 2 diabetes in Mexico has nearly doubled for adults aged ≥60. Increases in education and healthcare resources to manage chronic conditions have contributed to population-level increases in the cognitive functioning of older adults. However, research has not focused on older adults with chronic conditions such as diabetes.

Objective:

Our objective was to compare the cognitive functioning of Mexican adults aged ≥60 with diabetes in 2001 and 2018.

Methods:

Data came from Mexican Health and Aging Study. Our study used a cross-sectional design and included participants aged ≥60 with self-reported diabetes during the 2001 ( n = 1,052, mean age = 68.4, female = 59.6%) and 2018 ( n = 2,469, mean age = 70.6, female = 62.0%) observation waves. Five cognitive tests were used to create a score of global cognition. Generalized estimating equations were used to compare global cognition in 2001 to 2018.

Results:

Older adults in 2018 had more education and were more likely than older adults in 2001 to take oral medication for diabetes, insulin, and to check blood sugar weekly. Older adults in 2018 had higher global cognition than in 2001 when adjusting for age, gender, education, and health insurance coverage ( b = 0.38, SE = 0.02). This statistically significant difference remained after adjusting for health conditions, health behaviors, and diabetes management behaviors.

Conclusions:

Older adults in Mexico with self-reported diabetes in 2018 had higher cognitive function than in 2001. Future research is needed to investigate causes of the cohort differences in cognitive functioning among Mexican older adults with self-reported diabetes.
Detecting Dementia by Saliva Analysis: A Fingerprinting Unobtrusive Method Based on a Fast and Cheap Sensor System
Authors: Di Gioia Claudia , Santonico Marco , Zompanti Alessandro , Sabatini Anna , Grasso Simone , Ursini Francesca , Pedone Claudio , Galdi Flavia , Antonelli Incalzi Raffaele , Pennazza Giorgio
Published: August 2023

Background:

Recent studies have shown that oxidative stress plays a relevant role in Alzheimer’s disease (AD), and in the pathogenesis of vascular dementia (VaD). New diagnostic methods look for biological samples with non-invasive sampling methods. Among these, saliva shows an increase in oxidative stress products, thus a corresponding reduction in antioxidant products were found in dementia cases compared to healthy controls. Compounds identified in saliva include some hydrocarbons whose production has been related to the presence of reactive oxygen species.

Objective:

The hypothesis is that the voltammetric analysis performed on saliva could be a useful test for diagnosing dementia, potentially discriminating between AD and VaD.

Methods:

A single-center observational study was conducted on patients referred to the dementia clinic in the Neurology area and healthy controls recruited in the Orthopedics area of the Campus Bio-Medico Hospital in Rome. The study was aimed at evaluating the discriminative properties of salivary voltammetric analysis between healthy subjects and patients with dementia and, as a secondary outcome, between AD and VaD. A total of 69 subjects were enrolled, including 29 healthy controls, 20 patients with AD, and 20 patients with VaD. The degree of cognitive impairment was classified on the basis of the Mini-Mental State Examination score.

Results:

The results obtained are promising, with an accuracy of 79.7%, a sensitivity of 82.5%, and a specificity of 75.8%, in the discrimination of dementia versus controls.

Conclusions:

The methods tested demonstrate to be relevant in the discrimination between dementia and controls. A confirmatory study is already running.
Spatiotemporal Characteristics of Regional Brain Perfusion Associated with Neuropsychiatric Symptoms in Patients with Alzheimer’s Disease
Authors: Jiang Jiwei , Wang Anxin , Liu Yaou , Yao Zeshan , Sun Mengfan , Jiang Tianlin , Li Wenyi , Jiang Shirui , Zhang Xiaoli , Wang Yanli , Zhang Yuan , Jia Ziyan , Zou Xinying , Xu Jun
Published: August 2023

Background:

Current technology for exploring neuroimaging markers and neural circuits of neuropsychiatric symptoms (NPS) in patients with Alzheimer’s disease (AD) is expensive and usually invasive, limiting its use in clinical practice.

Objective:

To investigate the cerebral morphology and perfusion characteristics of NPS and identify the spatiotemporal perfusion circuits of NPS sub-symptoms.

Methods:

This nested case-control study included 102 AD patients with NPS and 51 age- and sex-matched AD patients without NPS. Gray matter volume, cerebral blood flow (CBF), and arterial transit time (ATT) were measured and generated using time-encoded 7-delay pseudo-continuous arterial spin labeling (pCASL). Multiple conditional logistic regression analysis was used to identify neuroimaging markers of NPS. The associations between the CBF or ATT of affected brain areas and NPS sub-symptoms were evaluated after adjusting for confounding factors. The neural circuits of sub-symptoms were identified based on spatiotemporal perfusion sequencing.

Results:

Lower Mini-Mental State Examination scores ( p < 0.001), higher Caregiver Burden Inventory scores ( p < 0.001), and higher CBF ( p = 0.001) and ATT values ( p < 0.003) of the right anteroventral thalamic nucleus (ATN) were risk factors for NPS in patients with AD. Six spatiotemporal perfusion circuits were found from 12 sub-symptoms, including the anterior cingulate gyri-temporal pole/subcortical thalamus-cerebellum circuit, insula-limbic-cortex circuit, subcortical thalamus-temporal pole-cortex circuit, subcortical thalamus-cerebellum circuit, frontal cortex-cerebellum-occipital cortex circuit, and subcortical thalamus-hippocampus-dorsal raphe nucleus circuit.

Conclusions:

Prolonged ATT and increased CBF of the right ATN may be neuroimaging markers for detecting NPS in patients with AD. Time-encoded pCASL could be a reliable technique to explore the neural perfusional circuits of NPS.
Unleashing the Power of Bayesian Re-Analysis: Enhancing Insights into Lecanemab (Clarity AD) Phase III Trial Through Informed t-Test
Authors: Costa Tommaso , Premi Enrico , Liloia Donato , Cauda Franco , Manuello Jordi
Published: August 2023

Background:

Clinical trials targeting Alzheimer’s disease (AD) aim to alleviate clinical symptoms and alter the course of this complex neurodegenerative disorder. However, the conventional approach of null hypothesis significance testing (NHST) commonly employed in such trials has inherent limitations in assessing clinical significance and capturing nuanced evidence of effectiveness on a continuous scale.

Objective:

In this study, we conducted a re-analysis of the phase III trial of lecanemab, a recently proposed humanized IgG1 monoclonal antibody with high affinity for Aβ soluble protofibrils, using a Bayesian approach with informed t-test priors.

Methods:

To achieve this, we carefully selected trial data and derived effect size estimates for the primary endpoint, the Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB). Subsequently, a series of Bayes Factor analyses were performed to compare evidence supporting the null hypothesis (no treatment effect) versus the alternative hypothesis (presence of an effect). Drawing on relevant literature and the lecanemab phase III trial, we incorporated different minimal clinically important difference (MCID) values for the primary endpoint CDR-SB as prior information.

Results:

Our findings, based on a standard prior, revealed anecdotal evidence favoring the null hypothesis. Additional robustness checks yielded consistent results. However, when employing informed priors, we observed varying evidence across different MCID values, ultimately indicating no support for the effectiveness of lecanemab over placebo.

Conclusion:

Our study underscores the value of Bayesian analysis in clinical trials while emphasizing the importance of incorporating MCID and effect size granularity to accurately assess treatment efficacy.
Characterising the Genetic Landscape of Amyotrophic Lateral Sclerosis: A Catalogue and Assessment of Over 1,000 Published Genetic Variants
Authors: McCann Emily P. , Grima Natalie , Fifita Jennifer A. , Chan Moi Fat Sandrine , Lehnert Klaus , Henden Lyndal , Blair Ian P. , Williams Kelly L.
Published: August 2023

Background:

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with genetic and phenotypic heterogeneity. Pathogenic genetic variants remain the only validated cause of disease, the majority of which were discovered in familial ALS patients. While causal gene variants are a lesser contributor to sporadic ALS, an increasing number of risk alleles (low penetrance genetic variants associated with a small increase in disease risk) and variants of uncertain significance have been reported.

Objective:

To examine the pathogenic potential of genetic variation in ALS, we sought to characterise variant- and gene-level attributes of previously reported ALS-implicated variants.

Methods:

A list of 1,087 genetic variants reported in ALS to March 2021 was compiled through comprehensive literature review. Individual variants were annotated using in silico tools and databases across variant features including pathogenicity scores, localisation to protein domains, evolutionary conservation, and minor allele frequencies. Gene level attributes of genic tolerance, gene expression in ALS-relevant tissues and gene ontology terms were assessed for 33 ALS genes. Statistical analysis was performed for each characteristic, and we compared the most penetrant variants found in familial cases with risk alleles exclusive to sporadic cases, to explore genetic variant features that associate with disease penetrance.

Results:

We provide spreadsheet (hg19 and GRCh38) and variant call format (GRCh38) resources for all 1,087 reported ALS-implicated variants, including detailed summaries for each attribute. We demonstrate that the characteristics of variants found exclusively in sporadic ALS cases are less severe than those observed in familial ALS.

Conclusions:

We provide a comprehensive, literature-derived catalogue of genetic variation in ALS thus far and reveal crucial attributes that contribute to ALS pathogenicity. Our variant- and gene-level observations highlight the complexity of genetic variation in ALS, and we discuss important implications and considerations for novel variant interpretation.
UCLMuevete: Increasing the amount of physical activity, work-ability, and cardiorespiratory fitness capacity in university workers through active breaks
Authors: Marin-Farrona Maria , Wipfli Brad , Thosar Saurabh S. , García-Unanue Jorge , Gallardo Leonor , Felipe Jose Luis , López-Fernández Jorge
Published: August 2023

BACKGROUND: Active break programs at the workplace are a promising initiative for increasing workers' physical activity (PA) levels, health, work-ability (WA), and social relationship. OBJECTIVE: To determine the impact of an Active Breaks workplace program based on Bandura’s Social Cognitive Theory (SCT) aligned with Behavior Change Techniques (BCT) on PA levels, cardiorespiratory fitness (CRF), WA, and social relationships among university workers. METHODS: #UCLMuévete is a quasi-experimental, 12-week intervention designed according to the TREND and TIDieR-PHP checklists. Sixty-nine university workers were recruited and placed into 17 teams of 3 to 5 people. Participants were instructed to take a 20-min active break every working day (walking, cycling, and functional training). The following variables were measured before and after the 12-week intervention: (1) Amount of PA with accelerometers, (2) CRF through the 6 Min-Walking Test (m), (3) Body composition (fat mass (gr), muscle mass (gr), and bone mineral content (g/cm3) through densitometry), (4) Stress with the BodyGuard2 device, (5) WA through Work Ability Index (WAI), and (6) Social relationships through an ad-hoc questionnaire. Part-time workers, pregnant women, and workers with physical disability were excluded. RESULTS: Significant improvements were observed in the amount of daily moderate-to-vigorous PA (Difference (Dif)., women +8.05 and men +12.31 minutes; p < 0.05; ES = 0.224; 0.379), CRF (Dif., women +52.98 and men +25.53 meters; p < 0.05; ES = 0.578; 0.209), and (Dif., women +2.16 and men +2.39; p < 0.05; ES = 0.150; 0.177). No significant changes were observed in body composition and stress. CONCLUSION: 20 min/day of aerobic and strength active breaks, based on SCT aligned to BCTs, improves university workers’ amount of PA, CRF, WAI, and social relationships.
LANDSCAPE ARCHITECTURE AS MEANS OF FORMING AN INCLUSIVE URBAN SPACE IN BUFFER ZONES OF CULTURAL HERITAGE OBJECTS
Authors: Matsokha Alina
Published: August 2023

The article presents the results of the author's research on the formation of an inclusive urban space by means of landscape architecture; the legal framework is considered; the main principle of creating a network of barrier-free pedestrian routes in the space of the middle city is determined (the principle of "frame on the frame"); methods of implementing barrier-free (delimitation of pedestrian-transport traffic; zoning of pedestrian parts of the street with combinations of different types of paving by texture and color and others). Based on the analysis of world theoretical and practical experience, the means of implementing barrier-free (paving, gardening, decorating, etc.) have been determined and a number of examples in European cities have been provided. An algorithm for the formation of inclusive urban space in buffer zones of the second category of indirect multifunctional use of cultural heritage objects located in Ukraine has been proposed. Recommendations on the adaptation of public spaces to form an inclusive urban space within buffer zones have been provided. 

According to the specifics of the architectural and landscape organization, the most difficult is the category of buffer zones "non-direct multifunctional usage" (according to I. Korotun). As this zone covers historical city centers, historical city areas and other areas occupied by residential and non-residential buildings thus, the priority function in this aspect arises the safety and comfort of people, and the Memorial Protection Object Facility acquires a secondary role. In Ukraine, 4 out of 8 World Heritage sites have buffer zones of non-direct multifunctional use ("Kyiv: St. Sophia Cathedral and nearby monastery buildings, Kyiv-Pechersk Lavra, Church of the Savior on Berestov" (1990); "Ensemble of the historical center of Lviv" (1998); "Residence of the Metropolitans of Bukovina and Dalmatia" (2011) and "Historical Center of Odesa" (2023)). 

An analysis of world experience in the formation of an inclusive urban environment revealed that the main methods of implementing this approach are the creation of a network of barrier-free pedestrian routes in the space of the city center. Within the buffer zones, this can be done through: the delineation of pedestrian-transport traffic; zoning of pedestrian zones with combinations of different types of landscaping, decoration and types of paving by texture and color; selection of paving and equipment colors in accordance with the scale of buffer zone development; arrangement of unhindered ways of pedestrians movement by leveling surface differences taking into account the security requirements of a particular site.
FUNDAMENTALS OF URBAN PLANNING ORGANIZATION OF ENERGYEFFICIENT ECOLOGICAL SETTLEMENTS TAKING INTO ACCOUNT ENERGY EFFICIENCY INDICATORS
Authors: Selikhova Yana
Published: August 2023

The article considers the basics of urban planning organization of energy-efficient ecological settlements (hereinafter - EEP) taking into account energy efficiency indicators, since the organization of these urban planning formations is a multifaceted process that is associated with various factors that are considered in various scientific fields. 

Energy-efficient ecological settlements - can become one of the options for a comfortable ecological and energy-saving living environment (ensuring the necessary microclimatic conditions in buildings, using natural technologies in lighting and ventilation, sustainable construction of low-rise, semi-underground and underground construction, application of natural architecture techniques, selection of local and ecological materials, assessment of the life cycle of the building, provision of alternative energy sources), which can become a full-fledged living space with all the necessary conditions, starting from providing people with homes, ending with places of work. 

The main aspects of the development of energy-efficient ecological settlements have been identified, including: - the aspect of the functional organization of the territory, taking into account orientation according to the sides of the world, landscape assessment of the territory, etc.; 

- aspect of permaculture design; - landscape and composition aspect; - the aspect of ecological and autonomous construction (use of natural or recycled materials, design of an energy-saving building form); - the aspect of independence from energy resources (solar energy, wind energy, geothermal energy, wave energy and biomass); - aspect of water resources management (complex system of drinking water management and management of reclaimed water for irrigation and toilets, rainwater storage system, biological wastewater treatment system, flood control system). - aspect of waste utilization and recycling (processing of solid household waste, composting of organic and human waste, used as biogas for obtaining energy and fertilizers for agriculture); - the aspect of rational planning of transport links and the road-trail network for the use of ecological transport; - aspect of socio-economic development (eco-industry, tourism, educational programs and community values).

A unified structural model of EEP design has been developed. The unified structural model is a brief description of the stages of design (sequence of actions – algorithm) for further design, which includes four stages: Stage I – determination of the territory as an EEP, Stage II – determination of EEP factors, Stage III – analysis of initial data for further design, IV stage – design of EEP. Based on the results of the research, the stages of urban planning organization of energy-efficient ecological settlements were revealed, taking into account energy efficiency indicators (on the example of the Kharkiv region), which are presented in the form of detailed schemes.
REGARDING THE CURRENT STATE OF URBAN PLANNING AND REGIONAL ACTIVITIES IN UKRAINE
Authors: Demin Mykola , Yatsenko Viktor , Berova Polina
Published: August 2023

This research paper examines the peculiarities of urban and regional planning activities in modern conditions. The importance of studying the preliminary stages of project research and educational activities that form a sustainable basis for urban planning and regional planning is considered: the field of economics, sociology, geography, ecology and engineering.

It is determined how the instability of their development affects the sustainable development of the human-environmental settlement system as a whole. The existing forms of settlement, such as settlement, suburban, group-territorial community, and their place in the general system of settlement - region, country - are considered. As a strategy of modern development, the paper considers the process of sociologization of the space in which society lives.

The current state of public interests in the space in which people live, work, and rest is considered. The main legislative and regulatory institutions of the advanced European countries that have managed to put urban planning and regional activities as one of the main prospects for development are presented.

The importance of creating the Urban Planning Code of Ukraine as a sustainable law is beyond doubt. The author proposes a model of planning organization of Ukraine in the structure of the European space as a model of integration. The main challenges of today's society to urban planning activities are formed: competitiveness, environmental friendliness, mobility, sociologization, sustainable urbanization. At the heart of the challenges posed by today's urban planning activities should always be a person and the space in which he or she organizes his or her existence.
INNOVATIVE METHOD FOR STUDYING THE DYNAMICS OF POLLUTION AND HUMIDITY CHANGES IN SPORTS FACILITIES: FITNESS ROOMS AND SWIMMING POOLS
Authors: Chоvniuk Yuriy , Cherednichenko Petro , Moskvitina Anna , Zolotar Luydmula
Published: August 2023

It is necessary to take into account the reaction time of the system to changes and provide for changes in parameters when using modern automation systems and indoor microclimate control with a dynamic change in the intake of harmful substances. The change in carbon dioxide (CO2) pollution and air humidity in sports facilities, such as fitness rooms and swimming pools, is a non-stationary random process with a complex type of non-stationarity and can be described by statistical characteristics. Obtaining these statistical characteristics is complicated by the probabilistic nature of the whole process and the presence of random systematic errors in measuring pollution (CO2) and air humidity of a particular sports facility, the specifics of the functioning of heat and mass transfer processes, moisture exchange in the premises of sports facilities (swimming pools, fitness halls, gyms, etc.). etc.) and has not been studied in modern scientific literature. Therefore, this study was carried out precisely in order to improve the situation and bring it out of the impasse (uncertainty) regarding sports facilities and premises for mass physical culture, recreation, and leisure. The paper proposes a comprehensive method for studying the dynamics of changes in pollution (CO2) and air humidity in a sports facility (fitness rooms, swimming pools, etc.). It allows you to determine the statistical characteristics of the process and identify it with an accuracy that is satisfactory for practical purposes (the error is no more than 10%). In the process of research, it is necessary to use daily diagrams of the operation of CO2 air pollution meters and moisture meters in fitness rooms and swimming pools for a long period of time (70 days). An optimal flow meter of air pollution with carbon dioxide (CO2) or a moisture meter should be built according to a discrete circuit with digital processing of information that comes from a sensor (an artificial intelligence system for controlling air gas exchange processes in a sports facility), according to an algorithm for determining a moving average over a period of 10 ... 20 minutes averaging of the signal and the interval for issuing results 2 ... 5 min. This is what will make it possible to reduce random measurement errors and ensure accurate reproduction of the dynamics of the processes of changing Ac(t) or Wp(t) (which, by the way, can be quite fleeting).
THEORETICAL ASPECTS OF MONITORING OF CULTURAL HERITAGE OBJECTS USING UNMANNED APPARATUS IN DENSE BUILDING CONDITIONS
Authors: Chumak Olga , Gorkovchuk Julia
Published: August 2023

Analyzing the present, it is difficult to imagine the scale of destruction of cultural heritage objects, buildings and structures of various purposes that our country has undergone. An important stage for the analysis and further reconstruction of objects of various purposes, including objects of cultural heritage, is the study of their condition. Equally important is the issue of monitoring cultural heritage objects, because according to the current legislation, their monitoring and inventory must be carried out. It is worth noting that the location of cultural heritage objects is important when choosing methods and technologies for monitoring, in particular, this article deals with the issue of monitoring in built-up areas. There are many traditional methods for monitoring and observing deformations, however, in this article, the authors made a theoretical analysis of the use of UAVs in photogrammetry, considered the main aspects of using UAVs for monitoring cultural heritage objects, and analyzed the application of this type of work in compressed conditions. The authors made conclusions regarding the relevance of the work performed by UAV-filming methods, highlighted the advantages and disadvantages of this method and divided them according to the following characteristics: social, economic, and organizational.
ON THE PROSPECTS OF DEVELOPMENT OF THE UKRAINIAN ACADEMY OF ARCHITECTURE
Authors: Shulyk Vasyl
Published: August 2023

The term "academy" originated in Ancient Greece, nowadays, it has preserved its main features acquired in the course of historical development. The phenomenon embodies the process of acquiring, preserving and transmitting knowledge, and includes the personalities and institutions that do so.

Academic culture is a broader concept for scientific culture. Also, the academic community is a broader notion for the scientific community. Accordingly, the Ukrainian Academy of Architecture is an academic society, not strictly scientific, because it includes architecture as a synthesizing or unifying form of the art of shaping the living environment of the population.

Joint activities of the Ukrainian Academy of Architecture and the National Union of Architects of Ukraine can bring tangible results, facilitate contacts with government agencies responsible for the development of architecture.

The development of the creative community in modern conditions necessitates the use of the main provisions of strategic and creative management. It allows to form a positive image of creative organization, to increase competitiveness, to use limited resources more effectively, to increase profit and to formulate a clear development strategy.

On the whole, proceeding from the above-mentioned, the main directions of the Ukrainian Academy of Architecture's activity during the nearest period must be the following: 1) acquiring (scientific research) knowledge; 2) preserving and passing on knowledge; 3) practical developments in architecture and town-planning; 4) promotion and publishing activities 5) maintenance of close cooperation with the Union of Architects of Ukraine, Academy of Construction of Ukraine, establishment of mutually beneficial cooperation with governmental bodies responsible for the development of architecture and urban planning.
Heavy metals concentrations in hake Merluccius merluccius (Linnaeus, 1758) from the Bay of Oran (Mediterranean Sea)
Authors: Djellouli Fayçal , Kaddour Amina , Belhoucine Fatma , Alioua Amel
Published: August 2023

To evaluate the potential human health risk to hake consumers, the bioaccumulation of heavy metals (Cd, Pb, and Zn) was measured in the edible tissues of hake Merluccius merluccius (Linnaeus, 1758) caught from Oran Bay on the western Algerian Mediterranean coast. Results revealed that the average metal concentrations varied significantly among sex and in target organs. The concentrations of metal accumulation take place preferentially in the liver compared to the muscle of hake species, with the highest levels found for Zn, followed by Pb and Cd. The Estimated daily intake (EDI) of each trace metal did not exceed the tolerable daily intake (TDI). Human health risk assessment from heavy metal exposure through fish consumption from Oran Bay for adults showed no significant non-carcinogenic adverse health risk since all calculated values for Target Hazard Quotient (THQ) and Total Target Hazard Quotient (TTHQ) were <1.
PENGARUH LEADERSHIP TRANSFORMASIONAL ATAS ORGANIZATIONAL CITIZENSHIP BEHAVIOR KEPADA KARYAWAN DAN DOSEN FUAD IAIN CURUP
Authors: Pefriyadi Pefriyadi , Alparedi Topan
Published: August 2023

The purpose of this study was carried out to see the effect of transformational leadership on organizational citizenship behavior on Employees and Lecturers at faculty of Ushuluddin, Adab, Da'wah (FUAD) IAIN Curup. The subjects used in this study were 52 employees and lecturers at FUAD IAIN Curup. In this study a quantitative design was used while the design in data collection carried out a questionnaire with five Likert scales of transformational leadership on organizational citizenship behavior. The analysis design used in this study is to use a simple linear regression test. The conclusion of this study shows that there is a positive impact of transformational leadership on organizational citizenship behavior of 11.035% for the employees and lecturers of FUAD IAIN Curup. The implication of this study is to increase understanding of the influence of transformational leadership.
Neuroarchitecture: how the built environment influences the human brain
Authors: Santos Viviane Cristina Marques dos
Published: August 2023

Applied neuroscience in architecture emerges to understand how the environment influences the human brain and behavior. This discipline aims to improve the quality of spaces for people, such as enhancing productivity in work environments, increasing concentration and learning capacity in students, or even improving the health and well-being of users. The justification for this study arises from the fact that humans spend more than 87% of their time indoors, not only due to the need to work and study but also because of the modern lifestyle that allows them to engage in various activities indoors. Given that people spend a significant amount of time indoors, neuroarchitecture seeks to design healthier environments that provide positive experiences for users. This study aims to discuss the importance and strategies of neuroarchitecture and present human sensory experiences in built environments. A literature review was used as the methodology for this work. It is concluded that neuroarchitecture is a promising approach to creating environments that enhance productivity, well-being, health, and cognitive performance since buildings accommodate not only the human body but also the memories, desires, and subconscious state of the human brain. Thus, architecture becomes a key element capable of unconsciously modifying our emotions, thoughts, decision-making processes, physiological state, and health.
Manejo odontopediátrico do bruxismo do sono: revisão narrativa da literatura
Authors: Ferreira Jéssica Pimentel Gomes , Nascimento Thayssa Davilla Queiroz do , Neves Joyce Marielle Tavares das , Mendonça Lucas Francisco Arruda , Peres Silvia Helena de Carvalho Sales , Oliveira Nayhane Cristine da Silva de , Meira Gabriela Figueiredo
Published: August 2023

Objetivo: realizar uma revisão de literatura sobre o tratamento de pacientes pediátricos com bruxismo do sono. Metodologia: Realizou-se uma revisão narrativa de literatura entre janeiro de 2022 a janeiro de 2023 na base de dados eletrônica PubMed MedLine, utilizando os descritores de pesquisa: “bruxism child”; “children”; “pediatric”; “pediatric dentistry” e “kid”. Foram incluídos para a elaboração deste trabalho 15 artigos. Dividiu-se essa revisão em cinco partes onde foi descrito a etiologia do bruxismo do sono, a epidemiologia, o diagnóstico e tratamentos disponíveis e os impactos dessa doença na saúde bucal e sistêmica das crianças. Resultados: a partir da análise dos estudos selecionados, observou-se que existem diversas possibilidades de tratamentos, sendo elas: utilização de dispositivos bucais, como placas rígidas, acompanhamento psicológico, acompanhamento médico para tratar distúrbios respiratórios, orientação sobre higiene do sono, utilização de remédios, terapia de fotobiomodulação, injeção de toxina botulínica, acupuntura associadas ou não a utilização de placas oclusais rígidas e tratamento complementar por meio da utilização de homeopáticos de forma que a terapêutica de escolha seja baseada na identificação do provável fator etiológico desencadeador do bruxismo, após realização da anamnese. Conclusão: as evidências científicas atuais elencam uma variedade de tratamentos para o bruxismo do sono na infância, de forma que seu manejo deva ser pautado no controle dos sinais e sintomas e prevenção de seus problemas secundários, como a trinca dentária, atrição dental e hipersensibilidade dentinária.
Relação entre posição de parto e grau de laceração perineal
Authors: Bezerra Alessandro Gonçalves , Moraes Ana Clara Monteiro , Molisani Julia Terra , Nascimento Lysya Gabriela Andrade , Rêgo Aljerry Dias do
Published: August 2023

As pesquisas relacionadas à manutenção da integralidade do períneo durante o trabalho de parto vaginal abordam o posicionamento adotado pela paciente como um dos fatores relevantes na prevenção de lacerações. Diante da liberdade de movimento da mulher durante a fase ativa do trabalho de parto e a divergência, entre os diferentes serviços, nas orientações repassadas às pacientes, este estudo avaliou a correlação entre posição adotada pela paciente durante o período expulsivo e a ocorrência de lacerações perineais espontâneas. Trata-se de um estudo correlacional, realizado através de entrevista direta com 184 parturientes no maior centro de referenciamento ginecológico e obstétrico do estado do Amapá, o Hospital da Mulher Mãe Luzia (HMML). Os questionamentos se referiam à posição adotada pela paciente, à orientação por parte da equipe de saúde e a presença de laceração. Informações secundárias, como o grau de laceração, a realização de episiotomia, os dados neonatais e o passado obstétrico da parturiente foram colhidos em prontuários e livros de registros da maternidade. Os dados obtidos foram analisados pelo Statistical Pachage for the Social Sciences – SPSS. Os resultados revelam que a posição de escolha de 85,3% das pacientes foi o decúbito dorsal (horizontalizada). Lacerações perineais foram evidenciadas em 53,1%, sendo 4,7% de terceiro grau. A episiotomia teve baixa prevalência (2,8%). Foi observado que 76% das mulheres não receberam orientação durante o pré-natal sobre o posicionamento no trabalho de parto. Já durante o parto, 47,8% receberam algum tipo de aconselhamento. O presente estudo não encontrou associação estatística suficiente entre a posição adotada e o desfecho da integridade perineal. A laceração do períneo, em qualquer grau, foi mais associada ao histórico obstétrico da paciente, sendo prevalente em primíparas. Notou-se, ainda, um déficit na abordagem, com as gestantes, quanto à mobilidade e posicionamento durante o parto, demonstrando a necessidade de intervenção na atenção do aconselhamento, pelos profissionais de saúde, às gestantes amapaenses.
Development of the composition and technology for obtaining a synthetic component of the basis of hydraulic oils for special equipment
Authors:   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»), Dimitrieva N. V. , Gavrilova I. A. ,   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»), Voronina A. V. ,   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»), Kulikova I. A. ,   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»), Sheikina N. A. ,   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»), Tyshchenko V. A. ,   Samara State Technical University
Published: August 2023

The rapid development of technology, the creation of promising products with characteristics corresponding to or exceeding the characteristics of the best world analogues, dictate the need to create a new level of quality oils – synthetic. The advantages of synthetic-based oils are excellent viscosity-temperature characteristics, good low-temperature fluidity, high anticorrosive properties, as well as increased thermal-oxidative stability, compatibility with materials. Since synthetic oils are chemically stable, they retain their original characteristics longer under adverse operating conditions. Other advantages of synthetic oils include increased resistance to shear deformations (due to the uniformity of the structure), high dispersing ability, fire resistance, chemical inertia and non-toxicity. It is also important that the synthetic base requires the introduction of a minimum amount of thickening additives. In addition, their resource significantly exceeds the resource of petroleum oils of a similar purpose. Among the numerous lubricants, a special place is given to low-viscosity hydraulic oils used in autonomous hydraulic drives of special equipment. The use of a basic synthetic base makes it possible to increase the guarantees of the shelf life and operation of hydraulic oil in products and ensure a quality preservation resource for 20 years or more.
Evaluation of the reactivation efficiency of hydrotreating catalysts
Authors:   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»), Tyukilina P. M. , Markova M. G. ,   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»), Kirillova E. V. ,   JSC «Middle Volga Oil Refining Research Institute» (JSC «MidVolgaNIINP»), Trusov O. A. ,   PJSC Rosneft Oil Company, Chernobrovin K. A. ,   PJSC Rosneft Oil Company, Boldinov V. A. ,   PJSC Rosneft Oil Company
Published: August 2023

Tests of diesel fuel hydrotreating catalysts have been carried out, which have passed the reactivation procedure according to the technology developed by JSC «all-Russian Oil Refining Research institute». The efficiency of the reactivation technology was evaluated of catalysts for hydrotreating diesel fuels and vacuum gas oil. Based on a comprehensive analysis of the physico-chemical and catalytic properties of regenerated, reactivated and fresh hydrotreating catalysts, the dynamics of changes in the operating characteristics of catalysts is investigated. The results obtained at the pilot plant were confirmed during an industrial run at the L-24/7 hydrotreating plant of JSC «Syzran Oil Refinery». The presented results demonstrate the high activity and stability of reactivated catalytic systems in the process of hydrotreating diesel fuel and vacuum gas oil, in comparison with the results of operation of fresh catalysts of similar brands. I confirm the results of monitoring the operation of reactivated catalytic systems at an industrial technological installation.
Extraction of phenol from phenolcontaining waters when using extractants
Authors:   JSC ", Alekhin V. S. ,   Middle Volga Oil Refining Research Institute",   (JSC ",   MidVolgaNIINP",   ), Tsederbaum V. G. ,   JSC "Middle Volga Oil Refining Research Institute" (JSC "MidVolgaNIINP"), Pershin A. B. ,   JSC "Middle Volga Oil Refining Research Institute" (JSC "MidVolgaNIINP")
Published: August 2023

Phenol and its derivatives are among the most dangerous pollutants entering the environment as part of wastewater from oil refineries and petrochemical plants, as well as pharmaceutical industry and construction materials. In surface water bodies, phenols occur in the form of their derivatives, namely: free phenols, phenolate ions and phenolates. The listed compounds have different degrees of toxicity, forming humus-like compounds as a result of polymerization and condensation reactions. For this reason, the treatment of phenolic wastewater is a very urgent problem in the petrochemical industry due to the high carcinogenicity of these impurities. Deep purification of water effluents is complicated by the fact that none of the known methods of removing phenols can achieve, with relatively acceptable technical and economic indicators, the required degree of purification. In accordance with the guidance document RD 52.24.480-2006 and the "Instructions for the formation and presentation of operational information on extremely high and high levels of surface water pollution, as well as their accidental pollution" (IGCE, Moscow, 2001), when assessing the pollution of natural waters with phenols, in all cases, 0.001 mg/dm3 is used as the MPC.