bluuebunny/crossref_metadata_2025 huggingface dataset:
An Urban Traffic Dataset Composed of Visible Images and Their Semantic Segmentation Generated by the CARLA Simulator
Authors: Rosende Sergio Bemposta , Gavilán David San José , Fernández-Andrés Javier , Sánchez-Soriano Javier
Published: December 2023

A dataset of aerial urban traffic images and their semantic segmentation is presented to be used to train computer vision algorithms, among which those based on convolutional neural networks stand out. This article explains the process of creating the complete dataset, which includes the acquisition of the images, the labeling of vehicles, pedestrians, and pedestrian crossings as well as a description of the structure and content of the dataset (which amounts to 8694 images including visible images and those corresponding to the semantic segmentation). The images were generated using the CARLA simulator (but were like those that could be obtained with fixed aerial cameras or by using multi-copter drones) in the field of intelligent transportation management. The presented dataset is available and accessible to improve the performance of vision and road traffic management systems, especially for the detection of incorrect or dangerous maneuvers.
Eye Pain Caused by Epithelial Damage in the Central Cornea in Aqueous-Deficient Dry Eye
Authors: Yoshikawa Yamato , Yokoi Norihiko , Kusada Natsuki , Kato Hiroaki , Sakai Rieko , Komuro Aoi , Sonomura Yukiko , Sotozono Chie
Published: December 2023

In this study, the severity of eye pain (EP) and associated objective findings were evaluated in aqueous-deficient dry eye (ADDE) patients using PainVision®, a quantitative pain-measuring device. This study involved 53 eyes of 53 ADDE patients (6 males and 47 females; mean age: 64.4 ± 13.4 [mean ± SD] years). Of those, 18 eyes of 18 patients underwent punctal occlusion, and EP and objective findings in those patients were evaluated before and after treatment. In all patients, the severity of EP as measured by PainVision® was assessed using the Pain Degree (PD). The median PD for the 53 patients was 30.6 µA/µA (interquartile range, 16.9–93.2), and the nasal and central corneal staining score and the upper lid-wiper epitheliopathy score were significantly correlated with PD (R = 0.33, 0.33, and 0.28, respectively) (all: p < 0.05). Using the least squares method, the central corneal staining score most significantly affected PD. In the 18 cases that underwent punctal occlusion, PD was significantly reduced (median PD: 24.8 to 7.1 µA/µA; p < 0.0001). Using the least squares method, the central corneal staining score and tear meniscus radius were significantly more influential as factors contributing to PD before and after treatment, and central corneal epithelial damage was the factor most associated with ADDE-related EP.
Regression of Neovascularization after Panretinal Photocoagulation Combined with Anti-VEGF Injection for Proliferative Diabetic Retinopathy—A Review
Authors: Gawęcki Maciej , Kiciński Krzysztof , Bianco Lorenzo , Battaglia Parodi Maurizio
Published: December 2023

Proliferative diabetic retinopathy (PDR) poses a significant therapeutic problem that often results in severe visual loss. Panretinal photocoagulation (PRP) has long been a mainstay treatment for this condition. Conversely, intravitreal anti-VEGF therapy has served as an alternative treatment for PDR. This review aimed to evaluate the effects of PRP combined with anti-VEGF therapy on the regression of neovascularization (NV), including functional outcomes and incidence of complications. The MEDLINE database was searched for articles evaluating regression of NV using a combination of the following terms: “proliferative diabetic retinopathy”, “anti-VEGF”, “panretinal photocoagulation”, and “combined treatment”. The search yielded a total of 22 articles. The analysis of their results indicated PRP combined with ant-VEGF therapy as superior over PRP alone in the management of PDR. Combination treatment yields better and faster regression of NV and a lower incidence of serious complications, such as vitreous hemorrhage and the need for pars plana vitrectomy. Nevertheless, complete regression of NV is not achieved in a significant proportion of patients. Further research is needed to establish the most effective schedule for intravitreal injections as an adjunct to PRP. The current literature shows that in some cases, cessation of anti-VEGF injection in combination treatment for PDR can lead to relapse of NV.
Categorizing Acute Respiratory Distress Syndrome with Different Severities by Oxygen Saturation Index
Authors: Wu Shin-Hwar , Kor Chew-Teng , Chi Shu-Hua , Li Chun-Yu
Published: December 2023

The oxygen saturation index (OSI), defined by FIO2/SpO2 multiplied by the mean airway pressure, has been reported to exceed the Berlin definition in predicting the mortality of acute respiratory distress syndrome (ARDS). The OSI has served as an alternative to the Berlin definition in categorizing pediatric ARDS. However, the use of the OSI for the stratification of adult ARDS has not been reported. A total of 379 invasively ventilated adult ARDS patients were retrospectively studied. The ARDS patients were classified into three groups by their incidence rate of mortality: mild (OSI < 14.69), moderate (14.69 < OSI < 23.08) and severe (OSI > 23.08). OSI-based categorization was highly correlated with the Berlin definition by a Kendall’s tau of 0.578 (p < 0.001). The Kaplan–Meier curves of the three OSI-based groups were significantly different (p < 0.001). By the Berlin definition, the hazard ratio for 28-day mortality was 0.58 (0.33–1.05) and 0.95 (0.55–1.67) for the moderate and severe groups, respectively (compared to the mild group). In contrast, the corresponding hazard ratio was 1.01 (0.69–1.47) and 2.39 (1.71–3.35) for the moderate and severe groups defined by the OSI. By multivariate analysis, OSI-based severe ARDS was independently associated with 28-D or 90-D mortality. In conclusion, we report the first OSI-based stratification for adult ARDS and find that it serves well as an alternative to the Berlin definition.
Hematological Complications in a COVID-19 Patient: A Case Report
Authors: Ianuà Eleonora , Caldarelli Mario , De Matteis Giuseppe , Cianci Rossella , Gambassi Giovanni
Published: December 2023

Hemophilia A is a hemorrhagic disorder caused by insufficient or inadequate coagulation factor VIII activity. Two different forms are described: congenital, hereditary X-linked, and acquired. Acquired hemophilia A (AHA) is a rare condition and it is defined by the production of autoantibodies neutralizing factor VIII, known as inhibitors. We report the case of a 72-year-old man with a clinical diagnosis of AHA after SARS-CoV-2 infection, which has been described in association with several hematological complications. SARS-CoV-2 infection could represent the immunological trigger for the development of autoantibodies. In our patient, SARS-CoV-2 infection preceded the hemorrhagic complications by 15 days. This lag time is in line with the other cases reported and compatible with the development of an intense immune response with autoantibody production. It is possible that since our patient was affected by type 1 diabetes mellitus, he was more prone to an immune system pathological response against self-antigens. A prompt, appropriate therapeutic intervention with activated recombinant factor VII administration and cyclophosphamide has led to rapid remission of clinical and laboratory findings.
Stochastic Dynamics of Fusion Low-to-High Confinement Mode (L-H) Transition: Correlation and Causal Analyses Using Information Geometry
Authors: Kim Eun-Jin , Thiruthummal Abhiram Anand
Published: December 2023

We investigate the stochastic dynamics of the prey–predator model of the Low-to-High confinement mode (L-H) transition in magnetically confined fusion plasmas. By considering stochastic noise in the turbulence and zonal flows as well as constant and time-varying input power Q, we perform multiple stochastic simulations of over a million trajectories using GPU computing. Due to stochastic noise, some trajectories undergo the L-H transition while others do not, leading to a mixture of H-mode and dithering at a given time and/or input power. One of the consequences of this is that H-mode characteristics appear at a smaller input power Q<Qc (where Qc is the critical value for the L-H transition in the deterministic system) as a secondary peak of a probability density function (PDF) while dithering characteristics persists beyond the power threshold for Q>Qc as a second peak. The coexisting H-mode and dithering near Q=Qc leads to a prominent bimodal PDF with a gradual L-H transition rather than a sudden transition at Q=Qc and uncertainty in the input power. Also, a time-dependent input power leads to increased variability (dispersion) in stochastic trajectories and a more prominent bimodal PDF. We provide an interpretation of the results using information geometry to elucidate self-regulation between zonal flows, turbulence, and information causality rate to unravel causal relations involved in the L-H transition.
Unveiling Connections: A Thorough Analysis of Sustainable Development Goals Integration within the Spanish Physical Education Curriculum
Authors: Boned-Gómez Salvador , Ferriz-Valero Alberto , Fröberg Andreas , Baena-Morales Salvador
Published: December 2023

This study analyses the relationship between the physical education (PE) curriculum in secondary education in Spain and the Sustainable Development Goals (SDGs). The Physical education curriculum of compulsory secondary education, as well as the complementary materials, were analysed through document analysis. Although there is no explicit relationship, the analysis reveals links between curricular elements and SDGs targets, particularly with SDG 4 (Quality Education), 3 (Health and Well-being), and 5 (Gender Equality). Other SDGs, such as 10 (Reducing Inequalities) and 12 (Responsible Consumption), are less related. The social dimension of sustainable development is most closely linked to PE. A historical analysis of the treatment of sustainable development in PE curricula in Spain is also presented, examining how they have evolved over time. The manuscript helps clarify how teachers and researchers can mobilize competencies to address global challenges in students’ lives as individuals and world citizens, fostering commitment and social responsibility. Furthermore, this work highlights the importance of integrating the SDGs into education and how PE can be a key tool in this process.
The Individual Work Performance Questionnaire: Psychometric Properties of the Italian Version
Authors: Platania Silvia , Morando Martina , Gruttadauria Stefania Valeria , Koopmans Linda
Published: December 2023

Individual work performance can be defined as individual behaviour capable of generating value and a competitive advantage for the organization. Furthermore, this construct is linked to other fundamental variables that constitute worker well-being, such as job satisfaction and engagement. Although important, a complete measure of individual work performance is still lacking in the Italian context. The objective of this work is to validate the Individual Work Performance Questionnaire (IWPQ) within the Italian organisational context. The IWPQ is a multi-dimensional construct consisting of task performance, contextual performance, and counterproductive work behavior. To investigate the psychometric properties of the Italian IWPQ, 1053 participants were enrolled, whose ages ranged between 19 and 69 years. EFA, CFA, and MCFA analyses were performed to test the structural factors of the IWPQ. The results supported the validity of the IWPQ in the Italian context; the final structure consisted of 17 items. Multigroup confirmatory factor analysis showed that the factor solution was invariant across both gender and occupational categories and found evidence of metric, uniqueness, scalar, and structural invariance. Convergent validity was also tested and demonstrated. Adequate studies on the importance of individual performance can be used to better understand and distinguish the different components affecting performance.
Redundant Topology Design Method for Schedule Traffic Transmission Based on IEEE802.1CB Standard: Optimizing NW-PSP Scheduling Performance
Authors: Han Jun-Young , Jeon Young-Hoo , Kim Hyeong-Jun , Lee Suk
Published: December 2023

This study proposes a method for designing redundant topologies in time-sensitive networking to transmit scheduled traffic (ST) while considering fault tolerance. In general, redundant topologies enhance network fault tolerance and are used in safety-critical applications that demand high reliability. These applications place a premium on real-time network performance, necessitating the consideration of the quality of service for time-critical traffic during the redundant topology design process. The primary objective of this study is to optimize the flowspan, which pertained to the scheduling performance of the no-wait packet scheduling problem during the redundant topology design phase. Specifically, we introduced a methodology for designing topologies tailored to transmit ST using the IEEE802.1CB mechanism. Comparisons with existing topology design approaches revealed the ability of the proposed method to enhance network fault tolerance and yield a topology that reduced flowspan of ST, thereby freeing up bandwidth for time-critical traffic.
Modeling of Hydrogen Dispersion, Jet Fires and Explosions Caused by Hydrogen Pipeline Leakage
Authors: Lin Yujie , Ling Xiaodong , Yu Anfeng , Liu Yi , Liu Di , Wang Yazhen , Wu Qian , Lu Yuan
Published: December 2023

Accidental hydrogen releases from pipelines pose significant risks, particularly with the expanding deployment of hydrogen infrastructure. Despite this, there has been a lack of thorough investigation into hydrogen leakage from pipelines, especially under complex real-world conditions. This study addresses this gap by modeling hydrogen gas dispersion, jet fires, and explosions based on practical scenarios. Various factors influencing accident consequences, such as leak hole size, wind speed, wind direction, and trench presence, were systematically examined. The findings reveal that both hydrogen dispersion distance and jet flame thermal radiation distance increase with leak hole size and wind speed. Specifically, the longest dispersion and radiation distances occur when the wind direction aligns with the trench, which is 110 m where the hydrogen concentration is 4% and 76 m where the radiation is 15.8 kW/m2 in the case of a 325 mm leak hole and wind under 10 m/s. Meanwhile, pipelines lacking trenching exhibit the shortest distances, 0.17 m and 0.98 m, at a hydrogen concentration of 4% and 15.8 kW/m2 radiation with a leak hole size of 3.25 mm and no wind. Moreover, under relatively higher wind speeds, hydrogen concentration stratification occurs. Notably, the low congestion surrounding the pipeline results in an explosion overpressure too low to cause damage; namely, the highest overpressure is 8 kPa but this lasts less than 0.2 s. This comprehensive numerical study of hydrogen pipeline leakage offers valuable quantitative insights, serving as a vital reference for facility siting and design considerations to eliminate the risk of fire incidents.
Lower-Dimensional Model of the Flow and Transport Processes in Thin Domains by Numerical Averaging Technique
Authors: Vasilyeva Maria , Mbroh Nana Adjoah , Mehrubeoglu Mehrube
Published: December 2023

In this work, we present a lower-dimensional model for flow and transport problems in thin domains with rough walls. The full-order model is given for a fully resolved geometry, wherein we consider Stokes flow and a time-dependent diffusion–convection equation with inlet and outlet boundary conditions and zero-flux boundary conditions for both the flow and transport problems on domain walls. Generally, discretizations of a full-order model by classical numerical schemes result in very large discrete problems, which are computationally expensive given that sufficiently fine grids are needed for the approximation. To construct a computationally efficient numerical method, we propose a model-order-reduction numerical technique to reduce the full-order model to a lower-dimensional model. The construction of the lower-dimensional model for the flow and the transport problem is based on the finite volume method and the concept of numerical averaging. Numerical results are presented for three test geometries with varying roughness of walls and thickness of the two-dimensional domain to show the accuracy and applicability of the proposed scheme. In our numerical simulations, we use solutions obtained from the finite element method on a fine grid that can resolve the complex geometry at the grid level as the reference solution to the problem.
Magnetohydrodynamic and Ferrohydrodynamic Fluid Flow Using the Finite Volume Method
Authors: Chrimatopoulos Grigorios , Tzirtzilakis Efstratios E. , Xenos Michalis A.
Published: December 2023

Many problems in fluid mechanics describe the change in the flow under the effect of electromagnetic forces. The present study explores the behaviour of an electric conducting, Newtonian fluid flow applying the magnetohydrodynamics (MHD) and ferrohydrodynamics (FHD) principles. The physical problems for such flows are formulated by the Navier–Stokes equations with the conservation of mass and energy equations, which constitute a coupled non-linear system of partial differential equations subject to analogous boundary conditions. The numerical solution of such physical problems is not a trivial task due to the electromagnetic forces which may cause severe disturbances in the flow field. In the present study, a numerical algorithm based on a finite volume method is developed for the solution of such problems. The basic characteristics of the method are, the set of equations is solved using a simultaneous direct approach, the discretization is achieved using the finite volume method, and the solution is attained solving an implicit non-linear system of algebraic equations with intense source terms created by the non-uniform magnetic field. For the validation of the overall algorithm, comparisons are made with previously published results concerning MHD and FHD flows. The advantages of the proposed methodology are that it is direct and the governing equations are not manipulated like other methods such as the stream function vorticity formulation. Moreover, it is relatively easily extended for the study of three-dimensional problems. This study examines the Hartmann flow and the fluid flow with FHD principles, that formulate MHD and FHD flows, respectively. The major component of the Hartmann flow is the Hartmann number, which increases in value the stronger the Lorentz forces are, thus the fluid decelerates. In the case of FHD fluid flow, the major finding is the creation of vortices close to the external magnetic field source, and the stronger the magnetic field of the source, the larger the vortices are.
Evaluation of the Novel mTA10 Selective Broth, MSB, for the Co-Enrichment and Detection of Salmonella spp., Escherichia coli O157 and Listeria monocytogenes in Ready-to-Eat Salad Samples
Authors: Costa-Ribeiro Ana , Lamas Alexandre , Prado Marta , Garrido-Maestu Alejandro
Published: December 2023

Multiplex assays implementing DNA-based methods have been demonstrated as suitable alternatives to culture-based microbiological methods; however, in most cases, they still require a suitable enrichment step. Finding suitable enrichment conditions for different bacteria may result in challenges. In the present study, a novel selective broth named MSB (mTA10 selective broth) was formulated for the simultaneous recovery of Salmonella spp., E. coli O157:H7 and L. monocytogenes. Attention was paid to ensure the optimal enrichment of L. monocytogenes as its enrichment is more challenging. To this end, cellobiose was added to increase the growth of L. monocytogenes, and sodium pyruvate was also added to improve the recovery of stressed bacteria. Four selective agents were added, namely nalidixic acid, sodium cholate, lithium chloride and potassium tellurite, to control the growth of interfering microorganisms. It was concluded that the novel broth was suitable for the simultaneous enrichment of the target pathogens, allowing them to reach concentrations higher than 7 log CFU/mL for each bacterium in pure culture. Furthermore, all heavily contaminated ready-to-eat salad samples reached concentrations higher than 5 log CFU/g. Finally, after 24 h of enrichment of spiked salad, it was possible to detect concentrations below 10 CFU/25 g.
Flammutoxin, a Degradation Product of Transepithelial Electrical Resistance-Decreasing Protein, Induces Reactive Oxygen Species and Apoptosis in HepG2 Cells
Authors: Wu Jianguo , Nong Yu , Chen Bingzhi , Jiang Yuji , Chen Yuanhao , Wei Chuanzheng , Tao Yongxin , Xie Baogui
Published: December 2023

Proteins from Flammulina filiformis were prepared by sodium chloride extraction and fractionated by ammonium sulfate precipitation with increasing saturation degrees to obtain the protein fractions Ffsp-30, Ffsp-50, Ffsp-70, Ffsp-90, and Ffp-90. Among these protein fractions, Ffsp-50 possessed the most significant cytotoxic effect against three human gastrointestinal cancer cell lines, viz. HT-29, SGC-7901, and HepG2. SDS-PAGE and MALDI-TOF/TOF MS/MS analyses revealed that flammutoxin (FTX) was present as a dominating protein in Ffsp-50, which was further evidenced by HPLC-MS/MS determination. Furthermore, native FTX was purified from Ffsp-50 with a molecular weight of 26.78 kDa, exhibiting notable cytotoxicity against gastrointestinal cancer cell lines. Both Ffsp-50 and FTX exposure could enhance intercellular reactive oxygen species (ROS) generation and induce significant apoptosis in HepG2 cells. FTX was identified to be relatively conserved in basidiomycetes according to phylogenetic analysis, and its expression was highly upregulated in the primordium as well as the pileus of the fruiting body from the elongation and maturation stages, as compared with that in mycelium. Taken together, FTX could remarkably inhibit cell growth and induce ROS and apoptosis in HepG2 cells, potentially participating in the growth and development of the fruiting body. These findings from our investigation provided insight into the antigastrointestinal cancer activity of FTX, which could serve as a biological source of health-promoting and biomedical applications.
Antibacterial Activity and Mechanism of Self-Assembly Spermidine-Capped Carbon Dots against Staphylococcus aureus
Authors: Cui Tianqi , Fan Ya , Liu Yaping , Fan Xuejing , Sun Yuxue , Cheng Guiguang , Cheng Jianjun
Published: December 2023

This paper investigated the antibacterial mechanism of spermidine-capped carbon dots (S-PCDs) against Staphylococcus aureus. The results showed that there were a large number of amino groups on the surface of S-PCDs and they had a high positive charge (+47.06 mV), which could be adsorbed on the negatively charged bacterial surface through electrostatic interaction and changed the permeability of the bacterial cell membrane. The extracellular protein and nucleic acid contents of S. aureus treated with S-PCDs were 5.4 and 1.2 times higher than those of the control group, respectively. The surface folds and defects of the bacterial cell membrane, and the leakage of cell contents were observed using SEM and TEM. The expression of metabolic oxidation regulatory genes dmpI, narJ and narK was upregulated and the intracellular ROS generation was induced, causing bacterial oxidative stress and eventually bacterial death. S-PCDs can effectively inhibit biofilm formation and had low cytotoxicity. The S-PCD treatment successfully inhibited microbial reproduction when pasteurized milk was stored at 25 °C and 4 °C. These results provide important insights into the antimicrobial mechanism of S-PCDs and lay the foundation for their application in the food field as a potentially novel bacteriostatic nanomaterial.
The Effect of the Supplementation of Humic Substances and Fermented Products in the Feed on the Content of Salinomycin Residues in Poultry Tissues
Authors: Hriciková Simona , Kožárová Ivona , Koréneková Beáta , Marcinčák Slavomír
Published: December 2023

The presence of antimicrobial residues in products of animal origin is a constant problem for consumer health. The aim of this study was to observe the effect of the addition of humic substances (H), fermented products (F) and a mixture of both (FH) to feed supplemented with the coccidiostat salinomycin, compared with a control group (C), on the content of salinomycin residues in the edible tissues of broiler chickens using two microbial inhibition screening methods, Explorer 2.0 test and the Screening Test for Antibiotic Residues (STAR), and a confirmatory competitive enzyme immunoassay analysis (Salinomycin ELISA Kit). The results of the microbial inhibition tests showed a gradual decline in the positive results in the tissue samples from the last day of salinomycin administration (30th day) tothe last day of fattening (37th day, day of slaughter) in group C and no positive results in the tissue samples from experimental groups H, F and FH slaughtered on the last day of fattening. Using the Salinomycin ELISA Kit, salinomycin was detected in the chicken muscle tissues of all the control and experimental groups. However, no sample from any group contained salinomycin at a concentration exceeding the maximum residue limits set by European law. The high level of significance (p < 0.001) confirmed the positive influence of the administration of humic substances and fermented products on the content of salinomycin residues in chicken tissues.
Impact of Nanoclays Addition on Chickpea (Cicer arietinum L.) Flour Film Properties
Authors: Cobos Ángel , Díaz Olga
Published: December 2023

Chickpea flour is an affordable natural blend of starch, proteins, and lipids, which can create films with suitable properties as an eco-friendly packaging material. Nanoclays’ incorporation into natural biopolymers enhances the barrier properties of the resulting nanocomposites, so they could improve the properties of flour films. The objective of this work was to assess the influence of three types of nanoclays (halloysite, bentonite, and Cloisite 20A) at two concentrations on the characteristics of chickpea flour films. In general terms, when the lowest dose (5%) was added, no or very slight significant differences with the control were observed in most parameters, except for thermal stability and opacity, which increased, and solubility, which decreased. At the highest concentration (10%), films containing any of the nanoclays demonstrated greater thermal stability, opacity, and rigidity while being less soluble than those without nanofillers. Bentonite exhibited superior film structure distribution compared to other nanoclays. At the highest concentration, it had the most significant impact on modifying the properties of chickpea flour films, increasing their tensile and puncture strengths while decreasing elasticity and water vapor permeability. The incorporation of nanoclays into chickpea flour films could be a useful technique to enhance their properties.
A New Method for Hybrid Bermuda Grass (Cynodon dactylon × C. transvaalensis Burtt.-Davy) Vegetative Propagation
Authors: Magni Simone , Sciusco Giuliano , Caturegli Lisa , Sportelli Mino , Federighi Tommaso , Fontanelli Marco , Minelli Alberto , McElroy Joseph Scott , Volterrani Marco
Published: December 2023

Hybrid Bermuda grasses (Cynodon dactylon × C. transvaalensis Burtt.-Davy) represent one of the greatest contributions to the growing quality of turfgrass in the warm season and transition zone areas of the world. Hybrid Bermuda grass production relies on vegetative propagation from sod or sprigs. In the past, efforts have focused on improving the technique of stolonizing (or sprigging) for establishment in new areas. Such propagation requires bulk harvesting and planting of all rhizomes and stolons. We have developed a novel method of propagation and establishment from a single node harvested from greenhouse grown stolons. Despite a stolon fraction bearing a single node being suitable for effectively propagating a warm-season turfgrass, the technique has been held as economically impractical until now. Our method has been developed to obtain the multiplication of plant material in soilless conditions by harvesting single-node sprigs, propagation of plants from the single nodes, and transplant of single plants in the field. The investigation aimed to identify values for method set-up. Indeed, node and internode size variability with differential between maximum diameters is crucial for discrimination. For Patriot Bermuda grass stolons, nodes exhibited a maximum diameter of 2.43 ± 0.46 mm, while internodes had a maximum diameter of 1.54 ± 0.16 mm. Based on these findings, a 2 mm sieve was selected, achieving an optimal ratio between the node fraction and internode residues. The sieve yielded 87% of node fractions and only 1% of internodes from the initial mix, demonstrating its efficacy. Further results for the transplanting phase indicated that a double release resulted in an average success rate of 98.8%, with only 6.9% blank cells when using a single release. The average was 149 plants per tray over 160 cells, representing a 93.1% success rate. These results underscore the efficiency and acceptability of the overall propagation process in alignment with market references.
Effectiveness of Proprioceptive Body Vibration Rehabilitation on Motor Function and Activities of Daily Living in Stroke Patients with Impaired Sensory Function
Authors: Yoon Hyunsik , Park Chanhee
Published: December 2023

Stroke patients experience impaired sensory and motor functions, which impact their activities of daily living (ADL). The current study was designed to determine the best neurorehabilitation method to improve clinical outcomes, including the trunk-impairment scale (TIS), Berg balance scale (BBS), Fugl-Meyer assessment (FMA), and modified Barthel index (MBI), in stroke patients with impaired sensory function. Forty-four stroke survivors consistently underwent proprioceptive body vibration rehabilitation training (PBVT) or conventional physical therapy (CPT) for 30 min/session, 5 days a week for 8 weeks. Four clinical outcome variables–the FMA, TIS, BBS, and MBI–were examined pre- and post-intervention. We observed significant differences in the FMA, BBS, and MBI scores between the PBVT and CPT groups. PBVT and CPT showed significant improvements in FMA, BBS, TIS, and MBI scores. However, PVBT elicited more favorable results than CPT in patients with stroke and impaired sensory function. Collectively, this study provides the first clinical evidence of optimal neurorehabilitation in stroke patients with impaired sensory function.
Exploring Predictors of Social Media Use for Health and Wellness during COVID-19 among Adults in the US: A Social Cognitive Theory Application
Authors: Elkefi Safa
Published: December 2023

During COVID-19, SM media was relied upon for health-related information-seeking and activity support. This study uses the social cognitive theory (SCT) and a representative dataset of the population in the US to explore the factors influencing patients’ perceptions of SM for health-related activities. As per SCT, consolidated factors comprised personal factors (sociodemographic, health perception, self-efficacy) and environmental factors (social isolation, purpose in life). Multivariate logistic regression analysis was conducted. Among the 6252 respondents, 95.15% rarely use SM to share personal health-related information, and 90.44% rarely use it to share general health-related information. Older individuals and Whites are less likely to consider SM for healthcare decisions. Education levels influence SM’s perceived reliability. Those with positive health perceptions find SM more suitable for healthcare discussions. Socially-isolated individuals are less likely to use SM for healthcare. Those with a strong sense of purpose are less inclined to trust it for health decisions and may question its accuracy. SM-based interventions should address sociodemographic differences. Our findings contribute to the literature by SCT relevance validation in identifying the antecedents of SM use in healthcare. Our results also help to understand the challenges to its adoption. This can help enhance SM-based communication strategies and interventions.
The Effect of Nudging on Compliance with Individual Prevention Measures against COVID-19: An Online Experiment on Greek University Students
Authors: Emmanouil Ioannis , Diamantis Manolis , Niakas Dimitris , Aletras Vassilis
Published: December 2023

Nudging has often been suggested as a means to promote health care efficiency and effectiveness by influencing behavior without restricting choice; its usefulness, however, has not been adequately assessed. We examined the effect of an altruistically framed awareness message about the novel coronavirus on the intention to comply with individual prevention measures against infection. A total of 425 Greek postgraduate students, which were randomly assigned into a treatment group and a control group, filled out a questionnaire on compliance and future intention to comply with six preventive measures. The results indicate that the altruistic message did not manage to influence the intention to comply. Moreover, compliance was positively associated with risk perception, whereas women showed both higher compliance and risk perception than men. Vulnerability to the novel coronavirus and a positive vaccination status against it were accompanied by a greater perception of risk, while one’s personal history of COVID-19 was associated with a lower intention to comply, lower risk perception, and higher health risk preferences. We conclude that nudging interventions should be evaluated before being adopted in practice, taking into account timing, target groups, and means of communication.
Nitrogen-Doped Carbon Matrix to Optimize Cycling Stability of Lithium Ion Battery Anode from SiOx Materials
Authors: Bie Xuan , Dong Yawei , Xiong Man , Wang Ben , Chen Zhongxue , Zhang Qunchao , Liu Yi , Huang Ronghua
Published: December 2023

This study prepared silicon oxide anode materials with nitrogen-doped carbon matrices (SiOx/C–N) through silicon-containing polyester thermal carbonization. Melamine was introduced as a nitrogen source during the experiment. This nitrogen doping process resulted in a porous structure in the carbon matrices, a fact confirmed by scanning electron microscopy (SEM). Pyridinic and quaternary nitrogen, but mainly tertiary nitrogen, were generated, as shown via X-ray photoelectron spectroscopy (XPS). Electrochemical tests confirmed that, as anode materials for a lithium-ion battery, SiOx/C–N provided better cycle stability, improved rate capability, and lower Li+ diffusion resistance. The best performance showed an activated capacity at 493.5 mAh/g, preserved at 432.8 mAh/g after the 100th cycle, with 87.7% total Columbic efficiency. Those without nitrogen doping gave 1126.7 mAh/g, 249.0 mAh/g, and 22.1%, respectively. The most noteworthy point was that, after 100 cycles, anodes without nitrogen doping were pulverized into fine powders (SEM); meanwhile, in the case of anodes with nitrogen doping, powders of a larger size (0.5–1.0 µm) formed, with the accumulation of surrounding cavities. We suggest that the formation of more prominent powders may have resulted from the more substantial nitrogen-doped carbon matrices, which prevented the anode from further breaking down to a smaller size. The volume expansion stress decreased when the powders decreased to nanosize, which is why the nanosized silicon anode materials showed better cycling stability. When the anodes were cracked into powders with a determined diameter, the stress from volume expansion decreased to a level at which the powders could preserve their shape, and the breakage of the powders was stopped. Hence, the diameters of the final reserved powders are contingent on the strength of the matrix. As reported, nitrogen-doped carbon matrices are more robust than those not doped with nitrogen. Thus, in our research, anodes with nitrogen-doped carbon matrices presented more large-diameter powders, as SEM confirmed. Anodes with nitrogen doping will not be further broken at a larger diameter. At this point, the SEI film will not show continuous breakage and formation compared to the anode without doping. This was validated by the lower deposition content of the SEI-film-related elements (phosphorous and fluorine) in the cycled anodes with nitrogen doping. The anode without nitrogen doping presented higher content, meaning that the SEI films were broken many times during lithiation/delithiation (EDS mapping).
Immunological Processes in the Orbit and Indications for Current and Potential Drug Targets
Authors: Cieplińska Katarzyna , Niedziela Emilia , Kowalska Aldona
Published: December 2023

Thyroid eye disease (TED) is an extrathyroidal manifestation of Graves’ disease (GD). Similar to GD, TED is caused by an autoimmune response. TED is an autoimmune inflammatory disorder of the orbit and periorbital tissues, characterized by upper eyelid retraction, swelling, redness, conjunctivitis, and bulging eyes. The pathophysiology of TED is complex, with the infiltration of activated T lymphocytes and activation of orbital fibroblasts (OFs) and autoantibodies against the common autoantigen of thyroid and orbital tissues. Better understanding of the multifactorial pathogenesis of TED contributes to the development of more effective therapies. In this review, we present current and potential drug targets. The ideal treatment should slow progression of the disease with as little interference with patient immunity as possible. In the future, TED treatment will target the immune mechanism involved in the disease and will be based on a strategy of restoring tolerance to autoantigens.
Comparison of Secondary Prevention Following Hysteroscopic Adhesiolysis in the Improvement of Reproductive Outcomes: A Retrospective Cohort Study
Authors: Wu Tianyu , Fang Tao , Dong Yuanhang , Mao Jingxia , Wang Jia , Zhao Ming , Wu Ruijin
Published: December 2023

Intrauterine adhesion (IUA) is primarily caused by endometrial injury, and hysteroscopic adhesiolysis is presently the main treatment. However, postoperative recurrence and poor pregnancy outcomes remain intractable. In this study, we aim to assess the effects of different treatments on clinical symptoms and reproductive outcomes in IUA. This retrospective study was conducted in a tertiary university-affiliated women’s hospital. The study included 1449 consecutive women who desired to have a baby and were diagnosed with IUA through hysteroscopy from January 2016 to December 2021. Patients with IUA underwent hysteroscopic electric resection (E) or cold scissors separation (C), as well as hormone therapy and one or both of the following secondary prevention measures: intrauterine devices (IUD) and hyaluronic acid gel (HA). The pregnancy rate (PR) was significantly higher in the E + IUD + HA (90.23% CI: 85.82, 94.64%) than in other groups (p = 0.000) groups. The rates of full-term birth (p = 0.000) and live birth (p = 0.000) were significantly higher in the E + IUD + HA (67.82% and 68.97%, respectively) and E + HA (62.41% and 63.91%, respectively) groups. Multivariate logistic regression analysis revealed a significantly higher PR in women who received second-look hysteroscopy (OR 1.571, 95% CI: 1.009–2.224, p = 0.013) and E + IUD + HA (OR 4.772, 95% CI: 2.534–8.987, p = 0.000). Combining hysteroscopic electric resection with IUDs and HA gel could prevent adhesion recurrence and improve postoperative pregnancy and live birth outcomes in IUA. Furthermore, postoperative second-look hysteroscopy may increase the PR and shorten the waiting period.
COVID-19 Vaccines in Children
Authors: Fayad Danielle , Frenck Robert W.
Published: December 2023

The COVID-19 pandemic has left an indelible mark on global health, affecting individuals of all ages across diverse communities. While the virus has predominantly been associated with severe outcomes in adults, its impact on children has garnered increasing attention. Today, three COVID-19 vaccines are available for use in the U.S. and recommended by the Advisory Committee on Immunization Practices (ACIP). As of September 2023, ongoing genomic surveillance identified SARS-CoV-2 XBB sublineages as the most common circulating SARS-CoV-2 variants, constituting over 99% of sequenced SARS-CoV-2 specimens in the US. Recently, recommendations for COVID-19 vaccination were updated accordingly to the 2023–2024 Omicron-XBB.1.5-adapted monovalent COVID-19 vaccine to provide heightened protection against currently circulating SARS-CoV-2 XBB-sublineage variants. COVID-19 vaccines have proven to be safe, efficacious, and effective at protecting against COVID-19 and preventing severe illness in children and adolescents.
Perceived Effects of Orthognathic Surgery versus Orthodontic Camouflage Treatment of Convex Facial Profile Patients
Authors: Psomiadis Simos , Gkantidis Nikolaos , Sifakakis Iosif , Iatrou Ioannis
Published: December 2023

Increased facial profile convexity has a common occurrence in the population and is a primary reason for seeking orthodontic treatment. The present study aimed to compare the perceived changes in facial profile appearance between patients treated with combined orthognathic/orthodontic treatment versus only orthodontic camouflage treatment. For this reason, 18 pairs of before- and after-treatment facial profile photos per treatment group (n = 36 patients) were presented to four types of assessors (surgeons, orthodontists, patients, laypeople). Ratings were recorded on 100 mm visual analogue scales depicted in previously validated questionnaires. All rater groups identified minor positive changes in the facial profile appearance after exclusively orthodontic treatment, in contrast to substantial positive changes (14% to 18%) following combined orthodontic and orthognathic surgery. The differences between the two treatment approaches were slightly larger in the lower face and the chin than in the lips. The combined orthodontic and orthognathic surgery interventions were efficient in improving the facial appearance of patients with convex profile, whereas orthodontic treatment alone was not. Given the significant influence of facial aesthetics on various life aspects and its pivotal role in treatment demand and patient satisfaction, healthcare providers should take these findings into account when consulting adult patients with a convex facial profile.
Effect of a Multicomponent Intervention with Tele-Rehabilitation and the Vivifrail© Exercise Programme on Functional Capacity after Hip Fracture: Study Protocol for the ActiveFLS Randomized Controlled Trial
Authors: Cedeno-Veloz Bernardo Abel , Casadamon-Munarriz Irache , Rodríguez-García Alba , Lozano-Vicario Lucia , Zambom-Ferraresi Fabricio , Gonzalo-Lázaro María , Hidalgo-Ovejero Ángel María , Izquierdo Mikel , Martínez-Velilla Nicolás
Published: December 2023

Introduction: Hip fractures are the most common fracture leading to hospitalization and are associated with high costs, mortality rates and functional decline. Although several guidelines exist for preventing new fractures and promoting functional recovery, they tend to focus on osteoporosis treatment and do not take into account the complexity of frailty in older adults and geriatric syndromes, which are important factors in individuals at risk of suffering from frailty fractures. Moreover, most health systems are fragmented and are incapable of providing appropriate management for frail and vulnerable individuals who are at risk of experiencing fragility fractures. Multicomponent interventions and physical exercise using tele-rehabilitation could play a role in the management of hip fracture recovery. However, the effectiveness of exercise prescription and its combination with a comprehensive geriatric assessment (CGA) is still unclear. Methods: This randomized clinical trial will be conducted at the Hospital Universitario de Navarra (Pamplona, Spain). A total of 174 older adults who have suffered a hip fracture and fulfil the criteria for inclusion will be randomly allocated to either the intervention group or the control group. The intervention group will receive a multicomponent intervention consisting of individualized home-based exercise using the @ctive hip app for three months, followed by nine months of exercise using Vivifrail. Additionally, the intervention group will receive nutrition intervention, osteoporosis treatment, polypharmacy adjustment and evaluation of patient mood, cognitive impairment and fear of falling. The control group will receive standard outpatient care according to local guidelines. This research aims to evaluate the impact of the intervention on primary outcome measures, which include changes in functional status during the study period based on the Short Physical Performance Battery. Discussion: The findings of this study will offer valuable insights into the efficacy of a comprehensive approach that considers the complexity of frailty in older adults and geriatric syndromes, which are important factors in individuals at risk of suffering from frailty fractures. This study’s findings will contribute to the creation of more effective strategies tailored to the requirements of these at-risk groups.
Remote Surgical Discussion of Multivessel Coronary Artery Disease Patients without Surgery on Site-Retrospective Insights
Authors: Roguin Ariel , Meisel Simha-Ron , Levi Yaniv , Kobo Ofer , Yehia Majd , Amsalem Naama , Abu Fanne Rami
Published: December 2023

Objective: The heart team approach is highly advocated for in treatment decision making in patients with multivessel disease (MVD). Nevertheless, many centers lack on-site cardiac surgical services (CSS)/formal heart team. Our local alternative is of remote surgical consultation without a structured image sharing platform. In our understanding, the incidence of anatomical complete revascularization (ACR) under this daily practice, and its clinical impact, has not been discussed before. Methods: We analyzed 477 consecutive patients who were surgically revascularized between January 2009 and March 2018 for MVD, after remote surgical consultation. Unstable, late arrival, and ST elevation patients were excluded (n = 163). ACR was considered grafting all anatomic lesions > 50%. Syntax score (SS) calculation and ACR categorization were determined by an independent interventionalist using diagnostic angiograms and available operative reports (n = 267). Patients’ outcomes were assessed in relation to multiple clinical variables including troponin result and the revascularization status. Results: Three hundred and fourteen patients were included. Mean age was 64 years, and mean SS-II was 27.3 ± 11. At the 4-year follow-up, the observed mortality (11.8% and 12.9%, with troponin-positive and -negative groups, respectively), myocardial infarction (11.8%), and repeat revascularization (9.8%) were higher than those predicted using a nomogram depicting the predicted 4-year mortality as a function of the SYNTAX II Score (5.3%, 8.8%, and 3.5%, respectively, p = 0.02). ACR was reported in 33% of 267 available patients’ reports. After multivariate adjustment ACR was the only variable associated with a significant increase in 4-year mortality (12.3% vs. 6.7%, p < 0.05). Conclusions: Partial revascularization in the absence of on-site CSS and a structured heart team platform is a frequent occurrence. Not surprisingly, this occurrence was associated with a higher risk for mid-term mortality. An upfront, structured, virtual, heart team interface is mandatory to particularly prioritize the completeness of revascularization when considering the optimal revascularization mode.