bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitamin D deficiency in western dwelling South Asian populations: an unrecognised epidemic
Authors: Darling Andrea L.
Published: February 2020

Vitamin D deficiency (25-hydroxyvitamin D; 25(OH)D) is at epidemic proportions in western dwelling South Asian populations, including severe deficiency (<12⋅5 nmol/l) in 27–60% of individuals, depending on season. The paper aimed to review the literature concerning vitamin D concentrations in this population group. Research from the UK and Europe suggests a high prevalence of South Asians with 25(OH)D concentration <25 nmol/l, with most having a 25(OH)D concentration of <50 nmol/l. In Canada, South Asians appear to have a slightly higher 25(OH)D concentration. There are few studies from the United States, South Africa and Australasia. Reasons for vitamin D deficiency include low vitamin D intake, relatively high adiposity, sun exposure avoidance and wearing of a covered dress style for cultural reasons. Possible health effects of deficiency include bone diseases such as rickets and hypocalcaemia in children and osteomalacia in adults. Vitamin D deficiency may also increase the risk of other chronic diseases. Increased fortification of food items relevant to South Asian groups (e.g. chapatti flour), as well as increased use of vitamin D supplements may help reduce this epidemic. Introducing culturally acceptable ways of increasing skin exposure to the sun in South Asian women may also be beneficial but further research is needed to assess the effectiveness of different approaches. There may be a need for a South Asian specific vitamin D dietary intake guideline in western countries. To conclude, vitamin D deficiency is epidemic in South Asians living in western countries and there is a clear need for urgent public health action.
National survey and molecular diagnosis of Echinococcus granulosus sensu lato in livestock in France, 2012
Authors: Umhang Gérald , Richomme Céline , Bastid Vanessa , Boucher Jean-Marc , Peytavin de Garam Carine , Itié-Hafez Sabine , Danan Corinne , Boué Franck
Published: February 2020

The parasitic species of the Echinococcus granulosus sensu lato (sl) complex are the causative agents of cystic echinococcosis in humans. The lifecycle of E. granulosus sl is essentially domestic, and is based on the consumption by dogs of hydatid cysts in viscera of livestock species. The aim of this study was to survey E. granulosus sensu lato in livestock in France. A 1-year national survey of E. granulosus sl in livestock at the slaughterhouse was organized in 2012 in France, with systematic molecular confirmation. The prevalence of E. granulosus ss nationally was 0.002% in sheep, mainly focused in the Alpine area, and 0.001% in cattle, with the distribution of cases throughout the country. Echinococcus canadensis G6/7 was observed only in Corsica in pigs, with a prevalence of nearly 1% in the island. A national prevalence of 0.0002% was estimated for E. ortleppi in cattle, due to seven cases distributed in two foci. The results of this survey are of particular interest because of the zoonotic risk associated with the presence of these parasite species, for which systematic control at the slaughterhouse should enable their elimination.
Peacebuilding without peace? On how pragmatism complicates the practice of international intervention
Authors: Bargués Pol
Published: February 2020

The International Relations (IR) literature has strongly criticised the invasive and top-down nature of liberal peace, facilitating a reinterpretation of the practice of international intervention in conflict-affected societies. Today, sustaining peace policy approaches advance longer-term missions, give a secondary role to external practitioners, and increasingly accept risks and failures. What is striking is that even when these policy discourses hold out the promise of liberating peacebuilding from dominant and top-down models of liberal intervention, the mood in the field is one of despair. By drawing on John Dewey's work on pragmatism and interviewing practitioners in Bosnia and Kosovo, the article reflects on the morass practitioners find themselves, diagnoses the source of the frustrations, and anticipates the direction of sustaining peace. Pragmatism adumbrates the idea of ‘peacebuilding without peace’, encouraging practitioners to experiment, give primacy to their doings and explore this world without hope of success and dreams of otherworldliness.
STOCHASTIC VOLATILITY MODEL WITH CORRELATED JUMP SIZES AND INDEPENDENT ARRIVALS
Authors: Chen Pengzhan , Ye Wuyi
Published: February 2020

In light of recent empirical research on jump activity, this article study the calibration of a new class of stochastic volatility models that include both jumps in return and volatility. Specifically, we consider correlated jump sizes and both contemporaneous and independent arrival of jumps in return and volatility. Based on the specifications of this model, we derive a closed-form relationship between the VIX index and latent volatility. Also, we propose a closed-form logarithmic likelihood formula by using the link to the VIX index. By estimating alternative models, we find that the general counting processes setting lead to better capturing of return jump behaviors. That is, the part where the return and volatility jump simultaneously and the part that jump independently can both be captured. In addition, the size of the jumps in volatility is, on average, positive for both contemporaneous and independent arrivals. However, contemporaneous jumps in the return are negative, but independent return jumps are positive. The sub-period analysis further supports above insight, and we find that the jumps in return and volatility increased significantly during the two recent economic crises.
Evaluation of immunisation strategies for pertussis vaccines in Jinan, China – an interrupted time-series study
Authors: Liu T. C. , Zhang J. , Liu S. Q. , Yin A. T. , Ruan S. M.
Published: February 2020

Studies in countries with high immunisation coverage suggest that the re-emergence of pertussis may be caused by a decreased duration of protection resulting from the replacement of whole-cell pertussis vaccine (WPV) with the acellular pertussis vaccine (APV). In China, WPV was introduced in 1978. The pertussis vaccination schedule advanced from an all-WPV schedule (1978–2007), to a mixed WPV/APV schedule (2008–2009), then to an all-APV schedule (2010–2016). Increases in the incidence of pertussis have been reported in recent years in Jinan and other cities in China. However, there have been few Chinese-population-based studies focused on the impact of schedule changes. We obtained annual pertussis incidences from 1956 to 2016 from the Jinan Notifiable Conditions Database. We used interrupted time series and segmented regression analyses to assess changes in pertussis incidence at the beginning of each year, and average annual changes during the intervention. Pertussis incidence decreased by 1.11 cases per 100 000 population (P= 0.743) immediately following WPV introduction in 1978 and declined significantly by 1.21 cases per 100 000 population per year (P< 0.0001) between 1978 and 2001. Immediately after APV replaced the fourth dose of WPV in 2008, the second and third doses in 2009, then replaced all four doses in 2010, pertussis incidence declined by 1.98, 1.98 and 1.08 cases per 100 000 population, respectively. However, the results were not statistically significant. There were significant increasing trends in pertussis incidence after APV replacements: 1.63, 1.77 and 1.78 cases/year in 2008–2016, 2009–2016 and 2010–2016, respectively. Our study shows that the impact of an all-WPV schedule may be less than the impacts of the sequential WPV/APV schedules. The short-term impact of APV was better than that of WPV; however, the duration of APV-induced protection was not ideal. The impact and duration of protective immunity resulting from APVs produced in China need further evaluation. Further research on the effectiveness of pertussis vaccination programme in Jinan, China is also necessary.
Exploring Ruist Influences of Moral Self-Cultivation on the Mandarin Union Version of the Chinese Bible (CUV)
Authors: HWANG TSUNG-I
Published: February 2020

The influences of Chinese traditional culture, especially the traditional Three Teachings and folk religion, on the Mandarin Union Version of the Chinese Bible (first edition, 1919) and the resulting complications are explicit in some contexts but implicit and subtle in other contexts. Some influences are helpful for Chinese people's proper understanding of biblical truth and theology in a Chinese context, but other influences can be misleading. In this paper, I will examine three translated Chinese phrases in the Mandarin Union Version that show evidence of Ruist influences: (1) “xūxīn de rén” “虛心的人”, in Matthew 5:3, (2) “tiānguó shì nǔlì jìnrù de﹐nǔlì de rén jiù dézháole” “天國是努力進入的﹐努力的人就得著了”, Matthew 11:12, and (3) “lǎoliàn” “老練”in Romans 5:4. Ruist influences is explicit in the first two cases but implicit in the third case, I will first analyze the verses and argue that they reflect the dominant Ruist ideology of moral self-cultivation instead of the biblical vision of transformation by “gracious moral cultivation”. Then I will demonstrate how Chinese readers might respond based on the context of each verse: Some Chinese readers might detect the inconsistenices between the Ruist emphasis on moral self-cultivation and a more general biblical theology, especially in an intertextual context of other Bible passages that explicitly teach the total depravity of human beings (e.g. Romans), as well as reconciliation and redemption by the free gift of Christ's grace for salvation and sanctification (e.g. Ephesians). Other Chinese readers might be misled by Ruist suggestions that they pursue sanctification and transformation only by means of moral self-cultivation that relies solely on their willpower. I will conclude by arguing how mistranslating and misinterpreting these verses can cause possible complications, especially negatively masking behaviour, in the personal and interpersonal spiritual transformation and ecclesiological development among Chinese Christians.
Radiobiological assessment of nasopharyngeal cancer IMRT using various collimator angles and non-coplanar fields
Authors: Sharbo G. , Hashemi B. , Bakhshandeh M. , Rakhsha A.
Published: February 2020

Aim:

The aim of this study was to evaluate clinical efficacy and radiobiological outcome of intensity-modulated radiation therapy (IMRT) modalities using various collimator angles and non-coplanar fields for nasopharyngeal cancer (NPC).

Materials and methods:

A 70-Gy planning target volume dose was administered for 30 NPC patients referred for IMRT. Standard IMRT plans were constructed based on the target and organs at risk (OARs) volume; and dose constraints recommended by Radiation Therapy Oncology Group (RTOG). Using various collimator angles and non-coplanar fields, 11 different additional IMRT protocols were investigated. Homogeneity indexes (HIs) and conformation numbers (CNs) were calculated. Poisson and relative seriality models were utilised for estimating tumour control probability (TCP) and normal tissue complication probabilities (NTCPs), respectively.

Results:

Various collimator angles and non-coplanar fields had no significant effect on HI, CN and TCP, while significant effects were noted for some OARs, with a maximum mean dose (Dmax). No significant differences were observed among the calculated NTCPs of all the IMRT protocols. However, the protocol with 10° collimator angle (for five fields out of seven) and 8° couch angle had the lowest NTCP. Furthermore, the standard and some of non-coplanar IMRT protocols led to the reduction in OARs Dmax.

Conclusions:

Using appropriate standard/non-coplanar IMRT protocols for NPC treatment could potentially reduce the dose to the OARs and the probability of inducing secondary cancer in patients.
Rapid Characterization of the July 2019 Ridgecrest, California, Earthquake Sequence From Raw Seismic Data Using Machine‐Learning Phase Picker
Authors: Liu Min , Zhang Miao , Zhu Weiqiang , Ellsworth William L. , Li Hongyi
Published: February 2020

The two principle earthquakes of the July 2019 Ridgecrest, California, earthquake sequence, MW 6.4 and 7.1, and their immediate foreshocks and thousands of aftershocks present a challenging environment for rapid analysis and characterization of this sequence as it unfolded. In this study, we analyze the first 6 days of the sequence using continuous data from available seismic networks to detect and locate earthquakes associated with the earthquake sequence. We build a high‐precision earthquake catalog using a deep‐neural‐network‐based picker—PhaseNet and a sequential earthquake association and location workflow. Without prior information, we automatically detect and locate more than twice as many earthquakes as the routine catalog. Our high‐precision earthquake catalog reveals detailed spatiotemporal evolution of the earthquake sequence and clearly defines multiple faults activated during the sequence. Our study demonstrates that it is possible to characterize earthquake sequences from raw seismic data using a well‐trained machine‐learning picker and our workflow.
Sea Level, Tidal, and River Flow Trends in the Lower Columbia River Estuary, 1853–present
Authors: Talke S. A. , Mahedy A. , Jay D. A. , Lau P. , Hilley C. , Hudson A.
Published: February 2020

Few tidal records are available pre‐1900 for the Pacific Ocean. We improve data coverage by recovering historical tabulations and digitizing analog tide rolls from Astoria, Oregon, for 1853–1876. Nearly 13,500 overlapping images of tides from 1855–1870 were digitized at a 6 min resolution using a line‐finding algorithm. Available hourly and high/low tabulations were also digitized, as were nearby hourly records from 1933 to 1943. Uncertainty was assessed by evaluating manual staff measurements, historical documents, and leveling surveys. Results suggest that uncertainty in mean sea level varies from ±0.07 m (early 1850s) to ±0.03 m (1867–1876) and is driven primarily by datum and benchmark uncertainty, rather than measurement precision, data reduction procedures, or hydrodynamic changes. We also corrected an up‐to 0.05 m error in the 1925–1960 tidal datum at Astoria. Harmonic analysis shows that major tidal constituents increased by up to 7% between 1855 and 2018. Mean tidal range increased by 0.1 m (5%), with more change occurring in July (0.17 m larger) than winter (0.07 m larger). By contrast, sea level increased most in winter and least in spring/summer. Tidally based estimates of river discharge suggest that these observations are caused by a ~50% reduction in peak spring discharge and a 30–60% increase in winter discharge. No evidence of altered upwelling is found. Overall, Astoria relative sea level (RSL) increased by 0.06 m ± 0.04 m since the 1858–1876 epoch or, after accounting for vertical land motion, 0.11 ± 0.09 m. Consistent with GNSS measurements, RSL has dropped near the estuary mouth since 1905, indicating a strong tectonic influence.
Responses of Foliar Nutrient Status and Stoichiometry to Nitrogen Addition in Different Ecosystems: A Meta‐analysis
Authors: Mao Jinhua , Mao Qinggong , Zheng Mianhai , Mo Jiangming
Published: February 2020

Atmospheric nitrogen (N) deposition alters the cycling of nutrients in terrestrial ecosystems. However, there is limited knowledge regarding how N addition affects foliar nutrients beyond N and phosphorus (P) and their stoichiometry. We conducted a meta‐analysis, including 2,004 observations from 134 fertilization studies, to synthesize the effects of N addition on multiple foliar nutrients and stoichiometry in terrestrial ecosystems and to examine their potential controls. Overall, we found that N addition significantly decreased foliar P, potassium (K), calcium (Ca), magnesium (Mg), and calcium:aluminium (Ca:Al) by 3.22%, 7.58%, 9.55%, 5.65%, and 15.17%, respectively, but significantly increased foliar N, Al, N:K, N:Ca, and N:Mg by 19.02%, 6.99%, 21.06%, 27.65%, and 11.33%, respectively. Among the forest ecosystems, foliar N and P exhibited greater changes in temperate or boreal forests, and foliar K, Mg, and Mn showed greater decreases or increases in tropical forests after N addition. Nitrogen addition significantly affected foliar K (−7.55%), Mg (−6.46%), and Al (+6.81%) in forests but not in grasslands. Similarly, foliar K, Mg, and Al showed significant changes in woody plants but not in herbaceous plants. In addition, we found that environmental factors (e.g., ambient N deposition, mean annual precipitation, and soil pH) affected foliar nutrient responses of N, K, and Mg to N addition. In summary, our findings indicate that N addition affects foliar nutrient contents, with the extent of these effects differing among ecosystem type. This is important for understanding and predicting plant growth and nutrient dynamics under N deposition scenarios.
Large‐Scale Assessment of Delayed Groundwater Responses to Drought
Authors: Hellwig J. , de Graaf I. E. M. , Weiler M. , Stahl K.
Published: February 2020

Groundwater is a vital resource for freshwater supply during extended droughts and also a key storage governing drought propagation through the hydrological cycle. Current drought monitoring lacks large‐scale estimates of groundwater droughts, but progress of country‐to‐global‐scale models in the last years suggests that they could now be valuable tools to study and monitor water availability during extended droughts. As a prerequisite the models would need to be able to depict the diverse groundwater response to precipitation well enough to distinguish spatial differences. Here we developed a high‐resolution transient groundwater model for Germany and tested its ability for representing the groundwater system dynamics with a focus on droughts. Validation of model results against streamflow‐separated baseflow and groundwater head observation confirmed the model's ability to generally represent the groundwater head dynamics over 40 years with lower model performance in mountainous regions where model resolution was too low to capture local valley aquifers. The precipitation accumulation time that has the highest correlation with groundwater anomalies increases with hydraulic conductivity and specific yield from few months in the Central German Uplands to several years in the porous aquifers of northern Germany. Corresponding to these differences, distinct meteorological drought types led to different simulated groundwater reactions across Germany. Given the importance of groundwater as a resource, large‐scale groundwater models are important tools for future studies on drought propagation as well as groundwater drought under climate change.
SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop
Authors: An Yifei , Wang Bo , Wang Xin , Dong Guoying , Jia Jihui , Yang Qing
Published: February 2020

Chemotherapy is the standard care for patients with gastric cancer (GC); however, resistance to existing drugs has limited its success. The persistence of cancer stem cells (CSCs) is considered to be responsible for treatment failure. In this study, we demonstrated that SIRT1 expression was significantly downregulated in GC tissues, and that a low SIRT1 expression level indicated a poor prognosis in GC patients. We observed a suppressive role of SIRT1 in chemoresistance of GC both in vitro and in vivo. In addition, we found that SIRT1 eliminated CSC properties of GC cells. Mechanistically, SIRT1 exerted inhibitory activities on chemoresistance and CSC properties through FOXO3 and AMPK. Furthermore, a synergistic effect was revealed between FOXO3 and AMPK. AMPK promoted nuclear translocation of FOXO3 and enhanced its transcriptional activities. In addition, FOXO3 increased the expression level and activation of AMPKα by directly binding to its promoter and activating the transcription of AMPKα. Similar to SIRT1, low expression levels of p-AMPKα and FOXO3a are also related to the poor prognosis of GC patients. Moreover, we revealed a correlation between the expression levels of SIRT1, p-AMPKα, and FOXO3a. These findings indicated the importance of the SIRT1-AMPK/FOXO3 pathway in reversing chemoresistance and CSC properties of GC. Thus, exploring efficient strategies to activate the SIRT1-AMPK/FOXO3 pathway may lead to improving the survival of GC patients.
ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
Authors: Paiano Jacob , Wu Wei , Yamada Shintaro , Sciascia Nicholas , Callen Elsa , Paola Cotrim Ana , Deshpande Rajashree A. , Maman Yaakov , Day Amanda , Paull Tanya T. , Nussenzweig André
Published: February 2020

Meiotic recombination is initiated by SPO11-induced double-strand breaks (DSBs). In most mammals, the methyltransferase PRDM9 guides SPO11 targeting, and the ATM kinase controls meiotic DSB numbers. Following MRE11 nuclease removal of SPO11, the DSB is resected and loaded with DMC1 filaments for homolog invasion. Here, we demonstrate the direct detection of meiotic DSBs and resection using END-seq on mouse spermatocytes with low sample input. We find that DMC1 limits both minimum and maximum resection lengths, whereas 53BP1, BRCA1 and EXO1 play surprisingly minimal roles. Through enzymatic modifications to END-seq, we identify a SPO11-bound meiotic recombination intermediate (SPO11-RI) present at all hotspots. We propose that SPO11-RI forms because chromatin-bound PRDM9 asymmetrically blocks MRE11 from releasing SPO11. In Atm–/– spermatocytes, trapped SPO11 cleavage complexes accumulate due to defective MRE11 initiation of resection. Thus, in addition to governing SPO11 breakage, ATM and PRDM9 are critical local regulators of mammalian SPO11 processing.
Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
Authors: Domínguez-Medina C. Coral , Pérez-Toledo Marisol , Schager Anna E. , Marshall Jennifer L. , Cook Charlotte N. , Bobat Saeeda , Hwang Hyea , Chun Byeong Jae , Logan Erin , Bryant Jack A. , Channell Will M. , Morris Faye C. , Jossi Sian E. , Alshayea Areej , Rossiter Amanda E. , Barrow Paul A. , Horsnell William G. , MacLennan Calman A. , Henderson Ian R. , Lakey Jeremy H. , Gumbart James C. , López-Macías Constantino , Bavro Vassiliy N. , Cunningham Adam F.
Published: February 2020

Lipopolysaccharide (LPS) O-antigen (O-Ag) is known to limit antibody binding to surface antigens, although the relationship between antibody, O-Ag and other outer-membrane antigens is poorly understood. Here we report, immunization with the trimeric porin OmpD from Salmonella Typhimurium (STmOmpD) protects against infection. Atomistic molecular dynamics simulations indicate this is because OmpD trimers generate footprints within the O-Ag layer sufficiently sized for a single IgG Fab to access. While STmOmpD differs from its orthologue in S. Enteritidis (SEn) by a single amino-acid residue, immunization with STmOmpD confers minimal protection to SEn. This is due to the OmpD-O-Ag interplay restricting IgG binding, with the pairing of OmpD with its native O-Ag being essential for optimal protection after immunization. Thus, both the chemical and physical structure of O-Ag are key for the presentation of specific epitopes within proteinaceous surface-antigens. This enhances combinatorial antigenic diversity in Gram-negative bacteria, while reducing associated fitness costs.
Mode-phase-difference photothermal spectroscopy for gas detection with an anti-resonant hollow-core optical fiber
Authors: Zhao Pengcheng , Zhao Yan , Bao Haihong , Ho Hoi Lut , Jin Wei , Fan Shangchun , Gao Shoufei , Wang Yingying , Wang Pu
Published: February 2020

Laser spectroscopy outperforms electrochemical and semiconductor gas sensors in selectivity and environmental survivability. However, the performance of the state-of-the-art laser sensors is still insufficient for many high precision applications. Here, we report mode-phase-difference photothermal spectroscopy with a dual-mode anti-resonant hollow-core optical fiber and demonstrate all-fiber gas (acetylene) detection down to ppt (parts-per-trillion) and <1% instability over a period of 3 hours. An anti-resonant hollow-core fiber could be designed to transmit light signals over a broad wavelength range from visible to infrared, covering molecular absorption lines of many important gases. This would enable multi-component gas detection with a single sensing element and pave the way for ultra-precision gas sensing for medical, environmental and industrial applications.
Metabolic responses of adult lion’s paw scallops Nodipecten subnodosus exposed to acute hyperthermia in relation to seasonal reproductive effort
Authors: Salgado-García Rosa L. , Kraffe Edouard , Maytorena-Verdugo Claudia I. , Rivera-Camacho Alma R. , Sicard M. Teresa , Arellano-Martínez Marcial , Racotta Ilie S.
Published: February 2020

In marine ectotherms, reproduction is an energetically expensive process that affects their thermal window tolerance. For most species, the impacts of hyperthermia during gametogenesis have still not been addressed. Our aim was to assess the metabolic response of adult Nodipecten subnodosus scallops to thermal challenges at early development (spring) and advanced gonad maturation (summer). Scallops collected in both seasons were exposed to acute hyperthermia (26 and 30 °C, 24 h), maintaining a group of scallops at acclimation temperature (22 °C) as a control condition. During the summer, relatively low activity of hexokinase (HK), as well as low levels of ATP and GTP were found in the adductor muscle, suggesting a shift in energy investment for reproduction, although arginine phosphate (ArgP) levels were higher in summer scallops. Hyperthermia (30 °C) induced an increased energy expenditure reflected by a transitory enhanced oxygen consumption (VO2) and relatively high activities of HK and arginine kinase (AK). Moreover, a slight decrease in adenylic energy charge (AEC) was partially compensated by a decrease in ArgP. An increase in nucleotide by-products inosine monophosphate (IMP) and hypoxanthine (HX) indicated a thermal stress at 30 °C. Some of the responses to acute hyperthermia were more pronounced at advanced maturation stages (summer scallops), indicating a possible lack of energy balance, with possible implications in animals challenged to global warming scenario.
Fully Printed PEDOT:PSS-based Temperature Sensor with High Humidity Stability for Wireless Healthcare Monitoring
Authors: Wang Yi-Fei , Sekine Tomohito , Takeda Yasunori , Yokosawa Koji , Matsui Hiroyuki , Kumaki Daisuke , Shiba Takeo , Nishikawa Takao , Tokito Shizuo
Published: February 2020

Facile fabrication and high ambient stability are strongly desired for the practical application of temperautre sensor in real-time wearable healthcare. Herein, a fully printed flexible temperature sensor based on cross-linked poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) was developed. By introducing the crosslinker of (3-glycidyloxypropyl)trimethoxysilane (GOPS) and the fluorinated polymer passivation (CYTOP), significant enhancements in humidity stability and temperature sensitivity of PEDOT:PSS based film were achieved. The prepared sensor exhibited excellent stability in environmental humidity ranged from 30% RH to 80% RH, and high sensitivity of −0.77% °C−1for temperature sensing between 25 °C and 50 °C. Moreover, a wireless temperature sensing platform was obtained by integrating the printed sensor to a printed flexible hybrid circuit, which performed a stable real-time healthcare monitoring.
Author Correction: Fossilized Melts in Mantle Wedge Peridotites
Authors: Naemura Kosuke , Hirajima Takao , Svojtka Martin , Shimizu Ichiko , Iizuka Tsuyosi
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Resonant energy transfer enhances solar thermal desalination
Authors: Alabastri Alessandro , Dongare Pratiksha D. , Neumann Oara , Metz Jordin , Adebiyi Ifeoluwa , Nordlander Peter , Halas Naomi J.
Published: February 2020

Water production from solar thermal desalination is limited by the energy consumption of phase change. Resonant heat exchange between matched saline feed and purified distillate flow rates enables optimized recovery of vaporization energy.
Gene expression in mouse muscle over time after nickel pellet implantation
Authors: Bannon Desmond I , Bao Wenjun , Turner Stephen D , McCain Wilfred C , Dennis William , Wolfinger Russ , Perkins Ed , Abounader Roger
Published: February 2020

The transition metal nickel is used in a wide variety of alloys and medical devices. Nickel can cause a range of toxicities from allergy in humans to tumors when implanted in animals. Several microarray studies have examined nickel toxicity, but so far none have comprehensively profiled expression over an extended period. In this work, male mice were implanted with a single nickel pellet in the muscle of the right leg with the left leg used as a control. At 3 week intervals up to 12 months, nickel concentrations in bioflulids and microarrays of surrounding tissue were used to track gene expression patterns. Pellet biocorrosion resulted in varying levels of systemic nickel over time, with peaks of 600 μg L−1 in serum, while global gene expression was cyclical in nature with immune related genes topping the list of overexpressed genes. IPA and KEGG pathway analyses was used to attribute overall biological function to changes in gene expression levels, supported by GO enrichment analysis. IPA pathways identified sirtuin, mitochondria, and oxidative phosphorylation as top pathways, based predominantly on downregulated genes, whereas immune processes were associated with upregulated genes. Top KEGG pathways identified were lysosome, osteoclast differentiation, and phasgosome. Both pathway approaches identified common immune responses, as well as hypoxia, toll like receptor, and matrix metalloproteinases. Overall, pathway analysis identified a negative impact on energy metabolism, and a positive impact on immune function, in particular the acute phase response. Inside the cell the impacts were on mitochondria and lysosome. New pathways and genes responsive to nickel were identified from the large dataset in this study which represents the first long-term analysis of the effects of chronic nickel exposure on global gene expression.
Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab
Authors: Samsudin Firdaus , Yeo Joshua Yi , Gan Samuel Ken-En , Bond Peter J.
Published: February 2020

The IgM antibody isotype of Pertuzumab affords simultaneous binding to antigens, but similar binding in Trastuzumab is hindered by steric clashes.
Wavelength-gated photoreversible polymerization and topology control
Authors: Frisch Hendrik , Mundsinger Kai , Poad Berwyck L. J. , Blanksby Stephen J. , Barner-Kowollik Christopher
Published: February 2020

We exploit the wavelength dependence of [2 + 2] photocycloadditions and -reversions of styrylpyrene to exert unprecedented control over the photoreversible polymerization and topology of telechelic building blocks.
Functionalized natural cellulose fibres for the recovery of uranium from seawater
Authors: Tellería-Narvaez Adrian , Talavera-Ramos Whitney , Santos Lucas Dos , Arias Jimena , Kinbaum Alejandro , Luca Vittorio
Published: February 2020

Simple organophosphonate functionalization of sisal fibres yields materials that extract uranium from sea water with high efficiency.
„Old Friends“, Immunregulation und Stressresilienz
Authors: Langgartner Dominik , Lowry Christopher A. , Reber Stefan O.
Published: February 2020

Es gibt zahlreiche Hinweise darauf, dass chronische negative Erfahrungen, insbesondere chronischer psychosozialer Stress, einen wesentlichen Risikofaktor für die Entstehung vieler somatischer und affektiver Störungen darstellen, einschließlich chronischer entzündlicher Darmerkrankungen (CED) und der posttraumatischen Belastungsstörung (PTBS). Die Mechanismen, die der Entstehung chronischer stressbedingter Erkrankungen zugrunde liegen, sind jedoch noch weitgehend unbekannt und die derzeitigen Behandlungs- und Präventionsstrategien sind unzureichend wirksam und zuverlässig. Ein besseres Verständnis der Mechanismen, die an der Entstehung und Aufrechterhaltung chronischer stressbedingter Erkrankungen beteiligt sind, kann zu neuen Ansätzen in der Prävention und Behandlung dieser Erkrankungen führen. In diesem 2-teiligen Review fassen wir die theoretischen Grundlagen (Teil 1) sowie die zugrunde liegenden Mechanismen (Teil 2) zusammen, welche die Hypothese stützen, dass ein Anstieg der Immun(re)aktivität und des Entzündungsgeschehens in der heutigen modernen Gesellschaft, potenziell gefördert durch einen verminderten Kontakt mit immunregulatorischen Mikroorganismen („Old Friends“), ursächlich an der gesteigerten Anfälligkeit für stressbedingte Pathologien sein könnte. Darüber hinaus diskutieren wir den künstlich herbeigeführten Kontakt mit Old Friends als vielversprechende Strategie zur Förderung der Stressresilienz und zur Vorbeugung/Behandlung chronischer stressbedingter Erkrankungen.
Rolle des Mikrobioms und der Darm-Gehirn-Interaktion bei Anorexia nervosa
Authors: Trinh Stefanie , Herpertz-Dahlmann Beate , Seitz Jochen
Published: February 2020

Das menschliche Darm-Mikrobiom ist am Stoffwechsel, der Gewichtsregulierung, der Entwicklung des Immunsystems sowie an der Interaktion zwischen Darm und Gehirn des Wirtes beteiligt. Patientinnen mit Anorexia nervosa (AN) zeigen deutliche Mikrobiomveränderungen, zum Beispiel eine reduzierte Bakterienvielfalt. AN-bezogene Veränderungen im Mikrobiom können die Darmpermeabilität, Entzündungsprozesse und die Bildung von Autoantikörpern fördern. Eine reduzierte Bakterienvielfalt in AN scheint mit Depressions-, Angst- und Essstörungssymptomen zusammenzuhängen. Auf das Mikrobiom ausgerichtete Therapien wie Ernährungsinterventionen oder Prä- und Probiotika könnten zusätzliche Behandlungsperspektiven bieten.
A Case Presentation on Rheumatic Heart Disease with Mitral Regurgitation
Authors: A. Jayasudha , B. Sreerenjini , P. Kaveri , P. Anitha
Published: February 2020

During any pregnancy there is an increase in blood volume of 30 to 50% resulting in increased pressure on the heart valves. For women with rheumatic heart disease this increased pressure presents increased maternal and/or fetal risks. Counseling of women with rheumatic heart disease gives appropriate surveillance of maternal and fetal well-being, as well as planning and documentation of the management of elective and emergency delivery. The care of pregnant women with rheumatic heart disease thus requires a multidisciplinary approach, involving obstetricians, cardiologists, and anesthetists. However, many women with rheumatic heart disease have healthy pregnancies and healthy babies with the right medical care.
To Share is Human! Advancing Evidence into Practice through a National Repository of Interoperable Clinical Decision Support
Authors: Lomotan Edwin A. , Meadows Ginny , Michaels Maria , Michel Jeremy J. , Miller Kristen
Published: February 2020

Background Healthcare systems devote substantial resources to the development of clinical decision support (CDS) largely independently. The process of translating evidence-based practice into useful and effective CDS may be more efficient and less duplicative if healthcare systems shared knowledge about the translation, including workflow considerations, key assumptions made during the translation process, and technical details.

Objective Describe how a national repository of CDS can serve as a public resource for healthcare systems, academic researchers, and informaticists seeking to share and reuse CDS knowledge resources or “artifacts.”

Methods In 2016, the Agency for Healthcare Research and Quality (AHRQ) launched CDS Connect as a public, web-based platform for authoring and sharing CDS knowledge artifacts. Researchers evaluated early use and impact of the platform by collecting user experiences of AHRQ-sponsored and community-led dissemination efforts and through quantitative/qualitative analysis of site metrics. Efforts are ongoing to quantify efficiencies gained by healthcare systems that leverage shared, interoperable CDS artifacts rather than developing similar CDS de novo and in isolation.

Results Federal agencies, academic institutions, and others have contributed over 50 entries to CDS Connect for sharing and dissemination. Analysis indicates shareable CDS resources reduce team sizes and the number of tasks and time required to design, develop, and deploy CDS. However, the platform needs further optimization to address sociotechnical challenges. Benefits of sharing include inspiring others to undertake similar CDS projects, identifying external collaborators, and improving CDS artifacts as a result of feedback. Organizations are adapting content available through the platform for continued research, innovation, and local implementations.

Conclusion CDS Connect has provided a functional platform where CDS developers are actively sharing their work. CDS sharing may lead to improved implementation efficiency through numerous pathways, and further research is ongoing to quantify efficiencies gained.
Development of a directly driven multi-shell platform: Laser drive energetics
Authors: Krasheninnikova Natalia S. , Schmitt M. J. , Molvig Kim , Hsu S. C. , Scheiner B. S. , Schmidt D. W. , Geppert-Kleinrath V. , McKenty P. W. , Michel D. T. , Edgell D. H. , Marshall F. J. , Huang H.
Published: February 2020

Simulations predict that directly driven multi-shell targets can provide a robust alternative to conventional high-convergence implosion concepts by coupling two to three times more energy into the final igniting thermonuclear fuel assembly than indirect-drive concepts. The three-shell directly driven Revolver concept [K. Molvig, M. J. Schmitt, B. J. Albright, E. S. Dodd, N. M. Hoffman, G. H. McCall, and S. D. Ramsey, Phys. Rev. Lett. 116, 255003 (2016)] utilizes a design that maximizes laser energy conversion into inward kinetic energy of the outermost ablator shell (∼9%) while minimizing the DT fuel convergence (∼9) to reduce the mixing of material from the innermost shell into the fuel. Inherent in this design concept is the use of 192 narrow beams (with a 1/e laser beam-to-capsule diameter ratio of 0.33) from the National Ignition Facility laser pointed in a polar direct drive laser configuration. In this paper, we demonstrate that low average laser intensity at the capsule surface (≤300 TW/cm2) limits the measured laser backscatter, indicating that a greater amount of laser energy is coupled into the target. Omega experiments have been performed to determine the coupling of laser energy to the outermost shell of a scaled Revolver target (i.e., the ablator shell) by measuring capsule implosion trajectories and scattered-light fractions for two different drive configurations. Comparisons of simulated shell trajectory and velocity profiles with experimental data obtained from self-emission images show good agreement and are consistent with measured scattered light data. Moreover, the low levels of scattered light measured are consistent with post-shot simulation results that show high hydro-coupling efficiency. These results strengthen the case for using narrow beams at low intensity to drive large ablator capsules for future direct-drive, multi-shell ignition concepts.
Tunable valleytronics with symmetry-retaining high polarization degree in SnSxSe1−x model system
Authors: Lin Shuren , Fang Zixuan , Hou Tingzheng , Hsu Ting Wan , So Chi H. , Yeoh Cher , Li Roger , Liu Yin , Chan Emory M. , Chueh Yu-Lun , Tang Bin , Persson Kristin , Yao Jie
Published: February 2020

SnS has recently been shown to possess unique valleytronic capability with a large polarization degree, where non-degenerate valleys can be accessed using linearly polarized light, bestowed upon by the unique anisotropy and wavefunction symmetry. It is thus of utmost importance to demonstrate the extension of such effects for the IV–VI system in general, thereby elucidating the generality and tunability of such valleytronics. We show the highly tunable valleytronics via gradual compositional control of the tin(II) sulfo-selenide (SnSxSe1−x) alloy system with excellent retainment of symmetry-determined selection rules. We show the presence of both ΓY and ΓX valleys in all alloy compositions via selectivity in absorption and emission of linearly polarized light by optical reflection (R)/transmission (T) and photoluminescence measurements and tuned the bandgaps of the valleys within a range of 1.28 eV–1.05 eV and 1.48 eV–1.24 eV, respectively. This simultaneous tuning of non-degenerate valleys agrees well with theoretical calculations. We then fitted the bandgap values in compositional space, obtaining bowing parameters as a useful database. We further demonstrated the feasibility of using IV–VI valleytronics systems in general by elucidating the retainment of strong polarization degrees of as high as 91% across all compositions. The generalization of such purely symmetry-dependent valleytronics also opens up opportunities for the discovery of more multi-functional materials.
Effect of asymmetric Pt thickness on the inverse spin Hall voltage in Pt/Co/Pt trilayers
Authors: Lo Tzu-Hsiang , Weng Yi-Chien , Pai Chi-Feng , Lin Jauyn Grace
Published: February 2020

Ferromagnetic resonance (FMR) is an effective technique for probing the magnetization dynamics of magnetic thin films. In particular, bilayer systems composed of a paramagnetic layer and a ferromagnetic layer are commonly used for FMR-driven spin pumping experiments. Spin pump-and-probe models have been adopted to obtain the spin Hall angle (θSHE) and spin diffusion length (λN) for various single layer and bilayer systems. Trilayer systems, however, have rarely been studied with the same model. In this work, we study the structural asymmetry effect on Pt/Co/Pt trilayers and find that the different thicknesses of Pt on two sides of Co may change the spin current sign. Furthermore, we propose a method that allows analysis of Pt/Co/Pt trilayers using the spin pump-and-probe model. The obtained values of θPt and λPt in the Pt/Co/Pt system are 0.116 nm and 1.15 nm, respectively, which are consistent with the values obtained from other Pt-based bilayer systems.
Investigation of the valence ionization spectrum of chromium carbonyl using an ab initio quantum dynamical approach
Authors: Nikoobakht Behnam
Published: February 2020

The nuclear dynamics of the chromium carbonyl cation following an ionization process corresponding to the 2T2g ← 1A1g transition is studied theoretically, for the first time, using a fully quantal approach as well as high levels of the ab initio electronic structure and semiempirical density functional theory (DFT) methods. The photoelectron spectrum is calculated by the construction of a Hamiltonian model, in which the two totally symmetric modes ν19 (the Cr–C stretching mode) and ν39 (the C–O stretching mode) together with the spin-orbit (SO) coupling up to the zeroth-order SO splitting are treated. The potential energy curves along these two vibrational modes are computed by using the DFT. The simulated photoelectron spectrum is found to be in good agreement with the corresponding experimental one, leading to the conclusion that the potential energy surfaces and the diabatic population analysis are accurately determined. Our calculation confirms that the vibrational modes ν19 and ν39 are the vibrational progression of the valence ionization spectrum of the chromium carbonyl cation.
Soft-information flipping scheme based on a priori LLRs summation for ultra-high density magnetic recording
Authors: Busyatras W. , Warisarn C.
Published: February 2020

Inter-track interference (ITI) is the main problem in high areal density (AD) of magnetic recording systems such as bit-patterned magnetic recording (BPMR) technology thus the ITI avoidance scheme is the way to improve the performance of the recording system. Two-dimensional (2D) modulation codes i.e., the rate-5/6 2D modulation code, was proposed to avoid the severe ITI effect which can successfully improve the system performance when it was considered without the codeword border effect. However, when we have to consider the codeword border effect, some upper and lower tracks cannot avoid ITI because both of them still be interfered from their sidetracks. To improve this weakness, a rate-5/6 2D modulation code was combined with the bit-flipping technique based on the normalization criteria of the two-dimensional soft-output Viterbi algorithm (2D-SOVA). Although, the bit-flipping technique can improve the performance of all tracks; however, the gain optimization is difficult to describe the relationship of the soft-information flipping technique. Therefore, this research proposes a novel of soft-information flipping scheme to describe the bit-flipping technique based on a priori log-likelihood ratios of the rate-5/6 encoding constraint in BPMR system. The simulation results clearly indicate that, at the same user density, the proposed system can provide bit-error-rate performance gain over the other recording systems in both of with and without position jitter noise.
Determination of a macro- to micro-scale progression leading to a magnetized plasma disruption
Authors: Seo Byonghoon , Wongwaitayakornkul Pakorn , Haw Magnus A. , Marshall Ryan S. , Li Hui , Bellan Paul M.
Published: February 2020

We report the observations of a plasma jet evolving through a macro- to micro-scale progression sequence. This leads to a fast magnetic reconnection that results in the jet breaking off from its originating electrode and forming a force-free state. A sausage-like pinching occurs first and squeezes an initially fat, short magnetized jet so that it becomes thin. The thin jet then becomes kink unstable. The lengthening of the jet by the kinking thins the jet even more since the kink is an incompressible instability. When the jet radius becomes comparable to the ion-skin depth, Hall and electron inertial physics become important and establish the environment for a fast magnetic reconnection. This fast reconnection occurs, disrupting the jet and establishing a force-free state. X-ray bursts and whistler waves, evidence of a magnetic reconnection, are observed when the plasma jet breaks off from the electrode. This experimentally observed sequence of successive thinning from pinching followed by kinking is reproduced in a three-dimensional ideal Magnetohydrodynamic (MHD) numerical simulation. The results of the experiment and the numerical simulation, together demonstrate a viable path from macro-scale MHD physics to micro-scale non-MHD physics where fast reconnection occurs.