bluuebunny/crossref_metadata_2025 huggingface dataset:
La Participation
Authors: Bessac Roselyne
Published: January 2022

Résumé Les Groupes d’entraide mutuelle (GEM) constituent l’unique mesure nouvelle concrète qui a accompagné la reconnaissance du handicap psychique dans la loi de 2005 pour répondre aux besoins spécifiques des personnes concernées. Cette contribution décrit la genèse de la création des GEM dans le Gard et le fonctionnement du dispositif de soutien mis en œuvre pour accompagner la vie du GEM dans l’élaboration de son projet associatif. À partir de l’expérience, l’auteur interroge les questions d’entraide, d’accès à l’autonomie des patients acteurs associatifs constitutifs du GEM ainsi que la place et les compétences des professionnels et des bénévoles.
Le care au risque de l’économie libérale
Authors: Depaulis Alain
Published: January 2022

À l’ère du coronavirus, le care ou caring s’offre une nouvelle jeunesse. S’il concerne d’abord le soin, il ne se prive pas de faire carrière en philosophie et d’inspirer les politiques. Cet article se propose d’évoquer le parcours de ce passionnant concept. Partant de son étymologie et de sa noble aspiration fondatrice, jusqu’à sa perversion dans l’économie libérale en passant par les variations dont il est l’objet.
Un mouchoir sur l’enfance ?
Authors: Coudeyras Laetitia
Published: January 2022

La Covid et le port du masque obligatoire pour les enfants des écoles primaires à la rentrée de novembre 2020 sont l’occasion d’évoquer ce que vivent les enfants du fait de l’épidémie. Confrontés à de nouvelles règles, à des interdits, à la peur manifestée par les adultes, au flux des nouvelles catastrophiques, à la mort, comment vont-ils absorber tout cela et se construire avec ? Comment les adultes peuvent-ils les aider à grandir dans un tel contexte ?
La Covid-19 face à l’intelligence collective
Authors: Garaix Anne , Trézéguet Muriel
Published: January 2022

Cet écrit permet de relater une expérience commune inédite : l’expérience du travail pendant le confinement. Il est l’occasion de « décrypter notre adn par un séquençage de notre génome » pour mieux comprendre qui nous sommes, comment nous travaillons et quels sont les leviers de notre organisation future construite sur des bases solides. C’est un bilan de cette expérience, travaillé suite à des séances de groupe d’analyse des pratiques post-Covid. Alors que pour certaines organisations cette crise engendre des inquiétudes, nous posons le constat inverse.
La confusion des incestes dans les théories et dans la réalité
Authors: Barry Aboubacar
Published: January 2022

Pour les théoriciens de l’anthropologie de la parenté, les prohibitions de l’inceste ont pour principal objectif d’instituer et de favoriser le principe sociologique de l’échange des femmes dans le groupe social. Une confrontation de cette conception avec des cas de familles incestueuses reçues en consultation psychothérapeutique montre plutôt que l’inceste réalisé introduit des confusions symboliques dans le système de parenté et que c’est peut-être la raison essentielle pour laquelle il est universellement interdit.
On the well-posedness of the anisotropically-reduced two-dimensional Kuramoto-Sivashinsky Equation
Authors: Massatt David
Published: January 2022

We address the global existence and uniqueness of solutions for the anisotropically reduced 2D Kuramoto-Sivashinsky equations in a periodic domain with initial data \begin{document}$ u_{01} \in L^2 $\end{document} and \begin{document}$ u_{02} \in H^{-1 + \eta} $\end{document} for \begin{document}$ \eta > 0 $\end{document}.
Boundedness in a two species attraction-repulsion chemotaxis system with two chemicals
Authors: Liu Aichao , Dai Binxiang , Chen Yuming
Published: January 2022

This paper deals with a class of attraction-repulsion chemotaxis systems in a smoothly bounded domain. When the system is parabolic-elliptic-parabolic-elliptic and the domain is \begin{document}$ n $\end{document}-dimensional, if the repulsion effect is strong enough then the solutions of the system are globally bounded. Meanwhile, when the system is fully parabolic and the domain is either one-dimensional or two-dimensional, the system also possesses a globally bounded classical solution.
Emergent behaviors of discrete Lohe aggregation flows
Authors: Choi Hyungjun , Ha Seung-Yeal , Park Hansol
Published: January 2022

The Lohe sphere model and the Lohe matrix model are prototype continuous aggregation models on the unit sphere and the unitary group, respectively. These models have been extensively investigated in recent literature. In this paper, we propose several discrete counterparts for the continuous Lohe type aggregation models and study their emergent behaviors using the Lyapunov function method. For suitable discretization of the Lohe sphere model, we employ a scheme consisting of two steps. In the first step, we solve the first-order forward Euler scheme, and in the second step, we project the intermediate state onto the unit sphere. For this discrete model, we present a sufficient framework leading to the complete state aggregation in terms of system parameters and initial data. For the discretization of the Lohe matrix model, we use the Lie group integrator method, Lie-Trotter splitting method and Strang splitting method to propose three discrete models. For these models, we also provide several analytical frameworks leading to complete state aggregation and asymptotic state-locking.
Optimal portfolios for the DC pension fund with mispricing under the HARA utility framework
Authors: Liu Zilan , Wang Yijun , Huang Ya , Zhou Jieming
Published: January 2022

This paper studies the optimal portfolio selection for defined contribution (DC) pension fund with mispricing. We adopt the general hyperbolic absolute risk averse (HARA) utility to describe the risk performance of the pension fund managers. The financial market comprises a risk-free asset, a pair of mispriced stocks, and the market index. Using the dynamic programming approach, we construct the Hamilton-Jacobi-Bellman (HJB) equation and obtain the explicit expressions for optimal portfolio choices with two methods. Finally, numerical analysis is presented to illustrate the sensitivity of the optimal portfolios to parameters of the financial market and contribution process. 200 words.
Haar wavelet method for solution of variable order linear fractional integro-differential equations
Authors: Amin Rohul ,   Department of Mathematics, University of Peshawar, 25120, Pakistan, Shah Kamal , Ahmad Hijaz , Ganie Abdul Hamid , Abdel-Aty Abdel-Haleem , Botmart Thongchai ,   Department of Mathematics, University of Malakand, Pakistan,   Department of Mathematics and General Sciences, Prince Sultan University, Riyadh, Saudi Arabia,   Information Technology Application and Research Center, Istanbul Ticaret University, 34445, Istanbul, Turkey,   Department of Mathematics, Faculty of Humanities and Social Sciences, Istanbul Ticaret University, 34445, Istanbul, Turkey,   Basic Science department, College of Science and Theoretical Studies, Saudi Electronic University-Abha Male 61421, Saudi Arabia,   Department of Physics, College of Sciences, University of Bisha, Bisha 61922, Saudi Arabia,   Physics Department, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt,   Department of Mathematics, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand
Published: January 2022

In this paper, we developed a computational Haar collocation scheme for the solution of fractional linear integro-differential equations of variable order. Fractional derivatives of variable order is described in the Caputo sense. The given problem is transformed into a system of algebraic equations using the proposed Haar technique. The results are obtained by solving this system with the Gauss elimination algorithm. Some examples are given to demonstrate the convergence of Haar collocation technique. For different collocation points, maximum absolute and mean square root errors are computed. The results demonstrate that the Haar approach is efficient for solving these equations.
Sliding-mode variable structure control for complex automatic systems: a survey
Authors: Wang Chengxuan ,   School of Electronic and Information Engineering, Suzhou University of Science and Technology, Suzhou, China, Tang Jiawei , Jiang Baoping , Wu Zhengtian ,   Suzhou Institute of Smart City, Suzhou University of Science and Technology, Suzhou, China
Published: January 2022

Automatic systems (ASs) can automatically control the work of controlled objects without unattended participation. They have been extensively used in industry, agriculture, automobiles, robots and other fields in recent years. However, the performance of the controller cannot meet the work requirements under complex environmental conditions. Therefore, improving the control performance is one of the difficult problems that automated systems should solve. Sliding-mode variable structure control has the advantages of fast response, insensitivity to uncertainty and interference and easy implementation; thus, it has been extensively used in the field of complex control systems. This article analyses and explains the research status of motors, microgrids, switched systems, aviation guidance, robots, mechanical systems, automobiles and unmanned aerial vehicles (UAVs) and prospects for the application of sliding-mode variable structure control in complex ASs.
Low Social Support and Risk for Depression in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
Authors: Azmiardi Akhmad , Murti Bhisma , Febrinasari Ratih Puspita , Tamtomo Didik Gunawan
Published: January 2022

Objectives: Depression is a frequent complication of type 2 diabetes mellitus. This study aimed to investigate the relationship between low social support and risk for depression in people with type 2 diabetes through a meta-analysis.Methods: PubMed, ProQuest, SpringerLink, ScienceDirect, Scopus, the Cochrane Library, Embase, and Google Scholar were searched for English-language articles published up to 2021. Pooled adjusted odds ratios (aORs) were calculated using a random-effect model with 95% confidence intervals (CIs). Heterogeneity was evaluated by using the Cochrane Q test and I2 statistics. The risk of publication bias was estimated using a funnel plot, the Egger test, and the Begg test. The Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of evidence and the risk of bias.Results: Eleven studies were included in this meta-analysis, containing a total of 3151 people with type 2 diabetes mellitus. The pooled analysis showed that people with type 2 diabetes mellitus who had low social support had twice as high a risk of depression as those with high social support (aOR, 2.02; 95% CI, 1.51 to 2.70; p<0.001). A random-effect model was used because the heterogeneity was high (I2= 87%).Conclusions: Low social support was found to increase the risk of depression among people with type 2 diabetes mellitus. Further investigation into factors that may moderate this relationship is required.
The Integration of Popular Culture in K-12 and Higher Education English Language Curricula
Authors: Garling Brittany Ann , Heiberger Ashley Steele
Published: January 2022

In this chapter, the authors present the approaches and benefits of integrating popular culture into the English language learning classroom. They provide background information on classroom use of technology and popular culture as well as student demographics. This chapter addresses counterarguments against the inclusion of popular culture for literacy development and explains why the advantages outweigh the concerns. Also discussing the teaching approaches that are supported by the incorporation of popular culture, the authors provide reasons and examples of effective curricula, including lessons, materials, and topics. The authors base their argument on research as well as personal experience to claim that the incorporation of popular culture will support linguistically and culturally responsive teaching approaches and will promote student engagement, connections, and motivation in ways that support learning for English language learners in both K-12 and higher education settings.
Should I Play or Should I Go?
Authors: Cermak-Sassenrath Daniel
Published: January 2022

A pervasive application of gamification in many areas of everyday life has arguably yet to happen. For instance, despite much commercial interest in and a potentially huge market for successful gamification products in the areas of education and health, much of the excitement is still based on speculation, and reception in parts of the academic community remains sceptical. The chapter aims to collate observations from multiple empirical studies and meta-studies and collect and highlight issues that need to be resolved or mitigated for gamification to progress. Such issues include unclear definitions, a limitation on small sets of elements employed with unclear effects, unintentional side-effects of competition, a confusing variety of operationalizations, the erosion of intrinsic motivation through extrinsic incentives, a disconnect between theoretical understandings and practical realizations, a strong focus on a behaviorist paradigm, studies' mixed, partial, and inconclusive results, a lack of attention to moderating factors, and methodological limitations.
Studying Thracian Civilization Through Serious Games and Storytelling
Authors: Paneva-Marinova Desislava , Goynov Maxim , Luchev Detelin , Pavlova Lilia , Márkus Zsolt László , Veres Miklós , Weisz Zsolt , Szántó György , Szkaliczki Tibor
Published: January 2022

This chapter presents a novel learning approach for studying ancient Bulgarian history, civilization, and their cultural heritage, namely the Thracian civilization, through storytelling and serious game combinations. The chapter also provides an overview of serious educational games, digital storytelling, and game development tools that can be used to present ancient history and their cultural heritage. The combination of storytelling and serious games successfully helps instructors to motivate student learning, stimulate their curiosity, and make them interested. The authors developed a game editor and a game portal that facilitated the game's development by applying game templates, layout styles, and question pools.
Effect of Formulation Variables for the Production of WGA-Grafted, Levodopa-Loaded PLGA Nanoparticles
Authors: Arisoy Sema , Comoglu Tansel
Published: January 2022

Levodopa is used for the treatment of Parkinson’s disease (PD) for the last few decades. However, adverse reactions such as dyskinesia, somnolence, nausea, itching, rash, as well as the need for frequent dosing and low bioavailability problems affect the success of the treatment. To prevent side effects caused by conventional therapy, a nanoparticular drug delivery system has been developed, in which receptors are constantly stimulated, and the frequency of dosing is reduced. In this study, levodopa was loaded in Poly lactic-co-glycolic acid (PLGA) nanoparticles (NP) which modified with Wheat Germ Agglutinin (WGA) To increase the effectiveness of levodopa, reduce its side effects and apply to the nasal area which is an alternative way for brain targeting with lower doses. To obtain the optimum levodopa loaded PLGA nanoparticles, the effect of some formulation variables such as polyvinyl alcohol (PVA) concentration, homogenization speed, polymer amount and molecular weight, and levodopa content on the entrapment efficiency (EE) and particle size of the nanoparticles were investigated. Besides these variables, the effect of different parameters on the WGA binding constant was also searched. In addition to in vitro release studies, Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectrophotometer (FT-IR), and Transmission electron microscopy (TEM) analysis were used in the characterization of nanoparticles. Among all formulations, A2 and A8a which was produced with different molcular weights of PLGA, different added levodopa amounts and with different homogenization speeds were chosen as optimum formulations due to their sustained release properties and the ability to release 80 % of their drug content.WGA binding constant was found 78.20 % for A8a-1 and 95 % for A2-1. In this study, we aimed to determine the effect of different formulation parameters on the development of levodopa loaded and WGA grafted PLGA nanoparticles and on the quality characteristics of nanoparticle formulations such as particle size, zeta potential, and EE. In this paper, our results are demonstrated for a better understanding of the effect of process parameters on the development of nanoparticle-based drug delivery systems by using the double-emulsion solvent evaporation technique and on WGA binding of drug-loaded PLGA nanoparticles.
Synthesis, Molecular Modeling, DNA Damage Interaction, and Antioxidant Potential of Hesperidin Loaded on Gold Nanoparticles
Authors: Sulaiman Ghassan Mohammad , Waheeba Hanaa M. , AL-Shmgani Hanady , Eassa Hamsa A. , Al-Amiery Ahmed A. , Jabir Majid S. , Dewir Yaser Hassan , Alwahibi Mona S. , Soliman Dina A.
Published: January 2022

The flavonoglycone hesperidin is recognized as a potent anti-inflammatory, anticancer, and antioxidant agent. However, its poor bioavailability is a crucial bottleneck regarding its therapeutic activity. Gold nanoparticles are widely used in drug delivery because of its unique properties that differ from bulk metal. Hesperidin loaded gold nanoparticles were successfully prepared to enhance its stability and bioactive potential, as well as to minimize the problems associated with its absorption. The free radical scavenging activities of hesperidin, gold nanoparticles, and hesperidin loaded gold nanoparticles were compared with that of Vitamin C and subsequently evaluated in vitro using 2,2-diphenyl-1-picrylhydrazyl assay. The antioxidant pharmacophore-based structure-activity relationship analysis was assessed by the density functional theory as well as quantum chemical calculations. Moreover, the structural properties were utilized using Becke’s three-parameter hybrid exchange and Lee-Yang-Parr’s correction of functional approaches. Hesperidin-loaded gold nanoparticles were found to decrease hydrogen peroxide (H2O2) and thus induce Deoxyribonucleic acid (DNA) instability. In addition, hesperidin-gold nanoparticles were observed to display important antioxidant potential as well as ameliorate the functional activity of macrophages against Escherichia coli, possibly protecting DNA. These particles might be appropriate for clinical trials and could prove useful for the treatment of various life-threatening disorders.
Semi-Solid 6061 Aluminum Alloy Slurry Prepared by Serpentine Channel Pouring Process and its Rheo-Diecasting
Authors: Li Nai Yong , Mao Wei Min , Geng Xiao Xin , Yan Peng Yu
Published: January 2022

Semi-solid 6061 aluminum alloy slurry was prepared by a graphite serpentine channel and its rheo-diecasting experiment was carried out on the slurry. The influence of pouring temperature on the microstructure evolution and mechanical properties of the rheo-diecasting were investigated. The microstructure and fracture mechanism of traditional die cast tensile specimens and rheo-diecast tensile specimens were compared and investigated. The results indicate that the microstructure of rheo-diecast tensile specimens is composed of spherical primary α-Al grains and fine secondary solidified α2-Al grains. When the pouring temperature increased from 660 °C to 720 °C, the average equivalent grain diameter of primary α-Al grains increased from 42 μm to 58 μm, and the shape factor decreased from 0.82 to 0.73. As the pouring temperature increases, the as-cast tensile strength and elongation of tensile specimens both increase first and then decrease. When the pouring temperature was 690 °C, the best mechanical properties were obtained, with as-cast tensile strength of 142.93 MPa and as-cast elongation of 4.86%. The fracture mechanism of traditional die casting is mainly ductile fracture, and the fracture mechanism of rheo-diecasting is a mixed fracture of intergranular fracture and ductile fracture.
Semisolid Materials Processing: A Sustainability Perspective
Authors: Jarfors Anders E.W. , Di An Dong , Yu Ge Gang , Zheng Jin Chuan , Wang Kai Kun , Wannasin Jessada
Published: January 2022

Sustainable development is increasing in importance with restrictions on emission and carbon footprint. Similarly, both energy and resources efficiency are required, and at the same time, cost-efficiency is required. The current paper is focusing on carbon footprint, energy usage and material use efficiency of semisolid metal casting. A detailed analysis is made on the RheoMetal process, which is benchmarked to conventional HPDC casting. The analysis includes the gating system and the importance of the use of primary or secondary material. It furthermore includes a discussion of process yield and benefits based on process capability.
Use of an Adaptive Management System to Minimize Impacts of Deep-Sea Nodule Collection
Authors: Buckley Toby , Jones Andy , Clarke Michael
Published: January 2022

Abstract In the nascent deep-sea mining industry, there is currently a high degree of uncertainty about what impacts prolonged metal extraction will have on the receiving environment. There is also concern regarding the transparency and monitoring of operations since the
target environment is extremely remote and inaccessible. Polymetallic nodule collection is being pursued, which is distinct from other forms of deep-sea mining in that the resource is distributed in a thin layer atop the seabed, unlike cobalt-rich crusts or massive sulfides, which are concentrated
in specific areas. The second distribution of nodules provides opportunities for dynamic mine planning not available for other mineral sources as many constraints normally affecting mining operations like waste stripping or underground development are absent. Also, the highly mobile ship-based
collection system that utilizes robotic collectors is easily relocated to other areas in response to emerging data on environmental constraints such as proximity to fragile habitats, sensitive species, or high cumulative impacts. An adaptive management system has been identified as a vital
strategy to address scientific uncertainty of ecological impacts of deep-sea mining. The design features dynamic mine planning, scenario modeling, and impact forecasting. Also, operating data will be transparently viewable in a publicly available dashboard. This paper describes an implementation
of a threshold-based framework for an effective adaptive management system designed to leverage the unique characteristics inherent to the resource.
Role of Lithium-Ion Batteries in Increasing the Operational Safety of Offshore Service Vessels
Authors: Vedachalam Narayanaswamy , Vandavasi Bala Naga Jyothi
Published: January 2022

Abstract For ensuring the operational safety of offshore service vessels (OSVs) during critical operations, marine classification agencies recommend operating redundant diesel generators (DGs) as a spinning reserve for dynamic positioning (DP) systems. In view of the reduced
fuel efficiency and increased emissions of DG sets when operated at low loads, lithium-ion (Li-ion) batteries are preferred as a green choice to serve the class-recommended DP power backup for 12 min. Based on the on-demand reliability analysis and Li-ion battery failure models, it is identified
that an OSV with a 1.6-MW‐capacity DP system requires 538 kWh of Li-ion battery power to reliably replace a spinning DG set in serving power backup for 12 min. Based on the IEC61508/11 health, safety, and environment framework, the methodology to identify the OSV risk under various
operational conditions and the battery system minimum maintenance interval requirements to meet various safety integrity levels are described.
Development and Subsea Testing of Polymetallic Nodule Crusher for Underwater Mining Machine
Authors: Ramesh Narayanmurthy Renganayahi , Thirumurugan Karuppiah , Raphael Deepak Chullickal , Ramadass Gidugu Ananda , Atmanand Malayath Aravindakshan
Published: January 2022

Abstract Polymetallic nodules found in the deep oceans are viewed as potential resources for meeting the world's demand of many metals in the near future. Polymetallic nodule mining systems require subsea crushing systems for reducing the size of nodules to facilitate energy-efficient
and safe pumping through risers of optimum size. Polymetallic nodules are friable, and deep-sea crushing has to be done with care to minimize the formation of fines, while obtaining the required size reduction. The crusher could also encounter objects with greater hardness during operation
like small rocks, splinters, long fish bones, and shark teeth. All components in the crusher should be capable of operating in the deep ocean environment, which is hyperbaric and sediment laden. The equipment should be compact with minimum weight. Reversal of direction and dumping arrangements
in the event of stalling are other essential design requirements. An underwater crusher capable of crushing mined nodules from a maximum size of 100 mm to a crushed size of 30 mm was developed using principles of design synthesis. The crusher was tested in land and integrated into a remotely
operated crawler-based underwater mining machine that could mine and pump nodules through a flexible riser. The system was tested using artificial nodules at 512-m water depth off the Malvan coast in the Arabian Sea. This paper describes developmental methodology, land-based performance tests,
and sea trials conducted on the developed crusher.
The Impact of Working Capital Management on Profitability: Evidence from Listed Companies in Sri Lankan Consumer Staples Sector
Authors: Thenuwara M. G. S. , Ekanayake N. P. K.
Published: January 2022

This study aims to investigate the impact of Working Capital Management on Profitability with special reference to the Consumer Staples Sector firms in Sri Lanka. Further, this sector displayed a considerable growth potential in Sri Lanka. This study is adopted in a quantitative research approach. Data were drawn from a sample of 46 Consumer Staple Sector firms listed in the Colombo Stock Exchange (CSE) for a period of five years commencing from 2014/2015 to 2018/2019. To test the hypothesized relationships between the constructs, the panel data analysis is performed using STATA. The study found that the Inventory Conversion Period has an insignificant negative impact on Profitability. Receivables Collection Period negatively and significantly impact the Profitability. Further, the study observed that the Payables Settlement Period has an insignificant positive impact on Profitability and observed a significant positive impact of the Current Assets Ratio on Profitability. The findings are useful to investors, managers and shareholders when making decisions regarding the firm’s profitability under aforementioned sector. This study is a contribution to the existing body of knowledge on Working Capital Management and it impact on the Profitability of listed companies in the Sri Lankan Consumer Staples Sector since the researchers used the recent data in the data analyzing process. Further, this paper is limited to the analysis of data obtained for five years by forty-six companies only. The time period and sample can further be increased by future researchers in order to broaden up the scope of the study.
Real World Evidence of Neoadjuvant Docetaxel/Carboplatin/Trastuzumab/Pertuzumab (TCHP) in Patients with HER2-Positive Early or Locally Advanced Breast Cancer: A Single-Institutional Clinical Experience
Authors: Kim Ji-Yeon , Nam Seok Jin , Lee Jeong Eon , Yu Jonghan , Chae Byung Joo , Lee Se Kyung , Ryu Jai Min , Ahn Jin Seok , Im Young-Hyuck , Kim Seok Won , Park Yeon Hee
Published: January 2022

Purpose Docetaxel/carboplatin/trastuzumab/pertuzumab (TCHP) regimen is frequently used to treat early and locally advanced human epidermal growth factor receptor 2 (HER2)–positive breast cancer (BC) in neoadjuvant setting. However, large-scaled real-world evidence did not exist.Materials and Methods We retrospectively reviewed medical records of patients with early or locally advanced HER2-positive BC who underwent neoadjuvant TCHP followed by curative surgery at Samsung Medical Center between January 2016 and August 2020.Results Of 447 patients, 316 (70.7%) received breast-conserving surgery and 131 (29.3%) received total mastectomy. In terms of neoadjuvant chemotherapy response, pathologic complete response (pCR) and residual cancer burden (RCB) score were analyzed. The rate of pCR was 64% a class of RCB 0 was observed in 65% of cases, RCB class I in 12%, RCB class II in 14%, and RCB class III in 2%. The 3-year event-free survival rate was 90.6%, BC with pCR occurred in 92.8%, and BC with non-pCR in 86.3% (p=0.016). In terms of distant metastasis, the 3-year distant recurrence-free survival rate was 93.5%; BC with pCR occurred in 95.9% and BC with non-pCR in 89.2% (p=0.013). Mucositis (85.2%), pain (83.2%), and diarrhea (70.5%) were the most common non-hematologic adverse events. In terms of hematologic adverse events, anemia (89.9%) was the most commonly observed adverse events followed by thrombocytopenia (29.8%).Conclusion Neoadjuvant TCHP therapy had a pCR rate of 64% and a 3-year event-free survival of 90% in real world experience. In terms of toxicity profile, anemia was frequently observed and adequate management including occasional transfusion was required.
The relative Mishchenko–Fomenko higher index and almost flat bundles II: Almost flat index pairing
Authors: Kubota Yosuke
Published: January 2022

This is the second part of a series of papers which bridges the Chang–Weinberger–Yu relative higher index and geometry of almost flat Hermitian vector bundles on manifolds with boundary. In this paper, we apply the description of the relative higher index given in part I to establish the relative version of the Hanke–Schick theorem, which relates the relative higher index with the index pairing of K-homology cycles and almost flat relative vector bundles. We also deal with the quantitative version and the dual problem of this theorem.
Optimal low-degree hardness of maximum independent set
Authors: Wein Alexander S.
Published: January 2022

We study the algorithmic task of finding a large independent set in a sparse Erdős– Rényi random graph with

n

vertices and average degree

d

. The maximum independent set is known to have size

(2 \log d / d)n

in the double limit

n \to \infty

followed by

d \to \infty

, but the best known polynomial-time algorithms can only find an independent set of half-optimal size

(\log d / d)n

. We show that the class of
low-degree polynomial algorithms
can find independent sets of half-optimal size but no larger, improving upon a result of Gamarnik, Jagannath, and the author. This generalizes earlier work by Rahman and Virág, which proved the analogous result for the weaker class of
local algorithms
.
Prior Carriage Predicts Intensive Care Unit Infections Caused by Extended-Spectrum Beta-Lactamase–Producing Enterobacteriaceae
Authors: Kallel Hatem , Houcke Stephanie , Resiere Dabor , Court Thibault , Roncin Cesar , Raad Mathieu , Nkontcho Flaubert , Demar Magalie , Pujo Jean , Hommel Didier , Djossou Felix
Published: January 2022

Intensive care unit–acquired infection (ICU-AI) and extended-spectrum beta-lactamase–producing Enterobacteriaceae (ESBL-PE) carriage are a major concern worldwide. Our objective was to investigate the impact of ESBL-PE carriage on ICU-AI. Our study was prospective, observational, and noninterventional. It was conducted over a 5-year period (Jan 2013–Dec 2017) in the medical-surgical intensive care unit of the Cayenne General Hospital (French Amazonia). During the study period, 1,340 patients were included, 271 (20.2%) developed ICU-AI, and 16.2% of these were caused by ESBL-PE. The main sites of ICU-AI were ventilator-associated pneumonia (35.8%) and primary bloodstream infection (29.8%). The main responsible microorganisms were Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae (ESBL-P in 35.8% of isolates), and Enterobacter cloacae (ESBL-P in 29.8% of isolates). Prior ESBL-PE carriage was diagnosed in 27.6% of patients with ICU-AI. In multivariable analysis, the sole factor associated with ESBL-PE as the responsible organism of ICU-AI was ESBL-PE carriage before ICU-AI (P < 0.001; odds ratio: 7.9 95% CI: 3.4-18.9). ESBL-PE carriers (74 patients) developed ICU-AI which was caused by ESBL-PE in 32 cases (43.2%). This proportion of patients carrying ESBL-PE who developed ICU-AI to the same microorganism was 51.2% in ESBL-P K. pneumoniae, 5.6% in ESBL-P Escherichia coli, and 40% in ESBL-P Enterobacter spp. NPV of ESBL-PE carriage to predict ICU-AI caused by ESBL-PE was above 94% and PPV was above 43%. Carriage of ESBL-P K pneumoniae and Enterobacter spp. is a strong predictor of ICU-AI caused by these two microorganisms.
Comparing Azithromycin to Amoxicillin in the Management of Uncomplicated Severe Acute Malnutrition in Burkina Faso: A Pilot Randomized Trial
Authors: O’Brien Kieran , Sié Ali , Dah Clarisse , Ourohiré Millogo , Ouedraogo Moussa , Boudo Valentin , Arzika Ahmed , Lebas Elodie , Nyatigo Fanice , Godwin William , Kelly John , Arnold Benjamin , Oldenburg Catherine
Published: January 2022

Azithromycin is a promising alternative to amoxicillin in the management of uncomplicated severe acute malnutrition (SAM) as it can be administered as a single dose and has efficacy against several pathogens causing infectious disease and mortality in children under 5. In this pilot trial, we aimed to establish the feasibility of a larger randomized controlled trial and provide preliminary evidence comparing the effect of azithromycin to amoxicillin on weight gain in children with uncomplicated SAM. We enrolled children 6–59 months old with uncomplicated SAM at six healthcare centers in Burkina Faso. Participants were randomized to a single dose of azithromycin or a 7-day course of amoxicillin and followed weekly until nutritional recovery and again at 8 weeks. Apart from antibiotics, participants received standard of care, which includes ready-to-use therapeutic food. Primary feasibility outcomes included enrollment potential, refusals, and loss to follow-up. The primary clinical outcome was weight gain (g/kg/day) over 8 weeks. Outcome assessors were masked. Between June and October 2020, 312 children were screened, 301 were enrolled with zero refusals, and 282 (93.6%) completed the 8-week visit. Average weight gain was 2.5 g/kg/day (standard deviation [SD] 2.0) in the azithromycin group and 2.6 (SD 1.7) in the amoxicillin group (mean difference −0.1, 95% CI −0.5 to 0.3, P = 0.63). Fewer adverse events were reported in the azithromycin group (risk ratio 0.50, 95% CI 0.31–0.82, P = 0.006). With strong enrollment and follow-up, a fully powered trial in this setting is feasible.
Analise multitemporal do desmatamento no município de Tomé-Açú entre 1985 a 2018
Authors: Sousa Larissa Melo de , Kato Osvaldo Ryohei , Adami Marcos , Souza Arlesson Antônio Almeida , Ramos Wilson Fernandes , Silva Igor dos Santos e
Published: January 2022

O objetivo desta pesquisa foi quantificar o desmatamento, considerando as mudanças espaciais e temporais da perda de floresta para o período de 1985 a 2018. Utilizou-se imagens do sensor Landsat para o mesmo período, referentes às órbitas/pontos 223/62 e 223/61. Foram realizadas composições coloridas RGB, realce linear de contraste das imagens e segmentação. Em seguida, realizou-se a interpretação das imagens por discriminação de classes. Os polígonos foram categorizados em 6 faixas de tamanho de áreas desmatadas. Adicionalmente, realizou-se a edição dos resultados do mapeamento e a elaboração de cartas temáticas. A expansão do desmatamento entre 1985 e 2018 acarretou perda de aproximadamente 298 mil ha de floresta (57% da área do município). Em todos os anos, foram observados valores elevados de polígonos no intervalo ≤ 6,25 ha e reduzido valor no intervalo > 50 ha. Os pequenos fragmentos (≤ 6,25 ha) respondiam por 15% de todo o desmatamento, enquanto os grandes (> 50 ha) respondiam por 45%. Ao longo do período analisado, foram observadas diferenças tanto na análise temporal, quanto nos padrões de distribuição do desmatamento, indicando forte potencialidade futura à perda de floresta.
The Influence and the legacy of the Latter Rain Movement on the Neo-Charismatic Movement
Authors: Resane Dr Kelebogile Thomas
Published: January 2022

The focus of this paper is to point out some doctrines of Branham , the morning star of the Latter Rain Movement that left some impact on the current Neo-Charismatic Movement. Through the solid literature review which was undertaken, an investigation in the historical development of this movement, and its impact on the current Neo-Charismatic churches is interrogated to obtain the facts. The NeoCharismatic Movement is a general term for independent charismatic formations that evolved after Pentecostalism that is these days dubbed Classical Pentecostalism. Since William Branham is noted for different teachings and practices pertaining to Pentecostalism, he is closely associated with the Latter Rain Movement of the forties and the fifties. There is no intention to lay out or elaborate on all Branham’s dogmatic dictums and practices, but only six are selected to complete the research question of this paper. These doctrines are the restorationist theology, deliverance, fivefold ministry, anti-cultural establishment, extra-biblical prophecies, and personality cult. It is discovered through this research that all these doctrines or practices are familiar within the Neo-Charismatic churches, especially those known as New Prophetic Churches.
A Novel Approach towards Automatic Contour Identification of Jaw Cysts from Digital Panoramic Radiographs to improvise the Treatment planning
Authors: Veena Divya K, , Jatti Anand , Vidya M. J. , Joshi Revan , Gade Srikar
Published: January 2022

Panoramic dental x-ray, a two-dimensional dental x-ray that captures the entire mouth in a single image, is used for the initial screening of various dental anomalies. One such is Jaw bone cyst, which, if not identified earlier, may lead to complications which in turn may lead to disfigurement and loss of function. Hence processing of radiographic images plays a vital role in identifying and locating the cystic region and extracting related features to assist clinical experts in further analysis. Objective: To develop an application of active contour model, known as Geodesic Active Contour, to generate Panoramic Dental X-Ray, a single 2 D X-ray image of the entire mouth highlighting the dental specifications. Methods: The process involves the image conversion from the OPG image into grayscale, Contrast adjustment using intensity level slicing, edge smoothing, segmentation, and cyst segmentation by Morphological Geodesic Active Contour to obtain the results. Hence processing of radiographic images plays a vital role in identifying and locating the cystic region. It is crucial in extracting related features to assist clinical experts in further analysis. Conclusion: When efficient and accurate diagnostic methods exist, the treatment and cure become easy and concrete. Based on the morphological snake and level sets, it aims at identifying the boundary by minimizing the energy. Results: Using the structural similarity index, an accuracy of 97.6% is obtained. Advances in Knowledge: This process is advantageous as it is simpler, faster, and does not suffer from instability problems. Morphological methods improve their functional gradient descent by improving stability and speed. The hysteresis algorithm exhibits better edge detection performance, a significant reduction in computational time and scalability.
Functional Reaction of the Cardiovascular System to Irritation of Vestibular Receptors in Students Engaged in Different Types of Martial Arts
Authors: Medvedev I. N. , Karpov V. Yu. , Makurina O. N. , Eremin M. V. , Dorontsev A. V. , Sibgatulina F. R. , Ivanov D. A.
Published: January 2022

Regular dosed physical activity in all cases has a tonic and healing effect on a person. Feasible muscle activity helps to improve the function of the heart, lungs, blood vessels and the nervous system. In martial arts, the reactivity of the vestibular apparatus is of great importance, providing the flow of information about the current position of the body in space, the success of movement in it and maintaining the stability of the posture due to the effective redistribution of muscle tone. Purpose of the work: to find out the dependence of the reaction of the cardiovascular system to the arising vestibular irritation in different types of martial arts. Martial arts classes help to increase the degree of vestibular stability. The statokinetic stability is very pronounced and increases in the course of hand-to-hand combat, which has a lot of moments with different severity of angular accelerations. The peculiarities of motor activity in any kind of martial arts inevitably affect the peculiarities of the reaction to the test with a change in the position of the head.
Financial Time Series Prediction Based on XGBoost and Generative Adversarial Networks
Authors: Xu Jialing , He Jingxing , Gu Jinqiang , Wu Huayang , Wang Lei , Zhu Yongzhen , Wang Tiejun , He Xiaoling , Zhou Zhangyuan
Published: January 2022

Considering the problems of the model collapse and the low forecast precision in predicting the financial time series of the generative adversarial networks (GAN), we apply the WGAN-GP model to solve the gradient collapse. Extreme gradient boosting (XGBoost) is used for feature extraction to improve prediction accuracy. Alibaba stock is taken as the research object, using XGBoost to optimize its characteristic factors, and training the optimized characteristic variables with WGAN-GP. We compare the prediction results of WGAN-GP model and classical time series prediction models, long short term memory (LSTM) and gate recurrent unit (GRU). In the experimental stage, root mean square error (RMSE) is chosen as the evaluation index. The results of different models show that the RMSE of WGAN-GP model is the smallest, which are 61.94% and 47.42%, lower than that of LSTM model and GRU model respectively. At the same time, the stock price data of Google and Amazon confirm the stability of WGAN-GP model. WGAN-GP model can obtain higher prediction accuracy than the classical time series prediction model.
Selective screening and molecular characteristics of Russian patients with Pompe disease
Authors: Savostyanov Kirill V. , Pushkov Alexander A. , Basargina Elena N. , Kuzenkova Lyudmila M. , Mazanova Natalia N. , Gandaeva Leila A. , Zharova Olga P. , Ryabova Ekaterina E. , Zhanin Ilya S. , Fisenko Andrey P.
Published: January 2022

Introduction. Pompe disease (PD) or type II glycogenosis is a rare multisystem hereditary accumulation disease caused by a deficiency of the enzyme acid maltase (acid alpha-1,4-glucosidase), which leads to reduced activity to the accumulation of glycogen in various organs and tissues of the body. The aim of the study is to develop a high-performance method of early biochemical diagnosis of PD and optimization of its molecular genetic diagnosis. Materials and methods. The characteristics of the relative frequencies and spectrum of the detected mutations were studied using a sample of 7670 patients with suspected Pompe disease admitted to the National Medical Research Center of Children’s Health of the Ministry of Health of Russia as part of the selective screening, as well as eight patients with PD, whose laboratory diagnosis was made outside the framework of this selective screening. Results. As a result of selective screening of PD in Russian patients from high-risk groups, the detectability was 0.47%. PD’s clinical and age characteristics in both children and adults are described. The relative frequencies are calculated, and the spectrum of 47 pathogenic variants of the GAA gene responsible for the occurrence and development of Pompe disease in 44 patients is characterized. Seventeen new mutations of the GAA gene, unknown previously, have been identified and described, adding 2.7% to the HGMD database. Conclusion. Optimization of the algorithm of molecular diagnosis of Pompe disease in Russian patients is proposed.
A clinical case of severe Duchenne muscular dystrophy caused by a nonsense mutation in the DMD gene in a girl
Authors: Podkletnova Tatyana V. , Kondakova Olga B. , Uvakina Eugeniya V. , Fisenko Dariya A. , Lyalina Anastasiya A. , Popovich Sophiya G. , Kuzenkova Lyudmila M. , Kurenkov Aleksey L. , Pak Lale A. , Bursagova Bella I.
Published: January 2022

Duchenne muscular dystrophy (DMD) is a hereditary progressive muscular dystrophy, mainly manifested in boys, is characterized by the onset at an early age, gradual symmetrical atrophy of the striated musculature of the limbs, trunk, as well as damage to the heart muscle. As a rule, girls and women inheriting a pathological mutation are classified only as its carriers and do not have clinical manifestations of the disease. Rare cases when women or girls show clinical manifestations of DMD may be due to chromosomal rearrangements involving the region of the short arm of the X chromosome (Xp21.2), deletions of this region, complete loss of the X chromosome (Shereshevsky-Turner syndrome), homogenous X chromosome dysomnia, compound heterozygous state for two pathogenic mutations in the DMD gene, nonequilibrium inactivation of the X chromosome. When female mutation carriers have DMD clinical symptoms, they usually manifest much milder than boys and young males. Descriptions of patients with the severe course and rapid progression of the disease, comparable in the rate of progression with boys, are rare. In this article, the authors share their experience of observing a girl patient who suffered from a severe form of DMD.
Innovation for Impact: An International Business Perspective on Transforming the United Nations
Authors: Tatarinov Katherine , Ambos Tina C.
Published: January 2022

While intrapreneurship and scaling are key themes in the International Business (IB) discussion, our research is the first to show how these concepts manifest in the context of the United Nations and how learnings from IB may be transferred. The United Nations (UN) organizations are tasked with solving the world’s pressing and difficult problems. These organizations are major players in international governance and are characterized by bureaucratic, globally dispersed and politically driven structures, but are hardly ever considered in IB research. The UN organizations are struggling to create innovative approaches to fulfil their core missions in today’s digital world and evidence shows that intrapreneurship and scaling innovation will be critical for transformation.
Taxonomic and ecological analysis of flora at locality „Djavolja Varoš“ (South Serbia)
Authors:   University of Priština in Kosovska Mitrovica, Faculty of Sciences and Mathematics,, Smiljić Mirjana , Papović Olivera , Đokić Mrđan , Marković Marija ,   University of Niš, Faculty of Sciences and Mathematics
Published: January 2022

Djavolja Varoš, one of the most atractive natural geological formations of errosive origin in Serbia, is situated in the south of the country, and protected by national legislation as a Natural Monument. The taxonomic and ecological analysis of flora in this area has not been processed yet, so we performed a survey of flora in this locality. Plant species were collected, herbarized, and taxonomic and biological spectrum analyses were conducted. This field study revealed that the vascular flora of the study area was made up of 130 constituent species, which belonged to 81 genera and 41 families. The biological spectrum of the flora is characterised by high presence of hemicryphytes (38%) and geophytes (20%).