bluuebunny/crossref_metadata_2025 huggingface dataset:
Dinamika jumlah dan pola sebaran kriminalitas sebelum hingga setelah COVID-19 di Kelurahan Damai, Kota Balikpapan
Authors: Abdissiam Dewani Agdis , Pratomo Rahmat Aris
Published: July 2024

Kriminalitas adalah segala macam tindakan yang merugikan secara ekonomis dan psikologis serta merupakan struktur sosial yang dapat berubah dari waktu ke waktu. Peningkatan kriminalitas dapat disebabkan oleh kejadian luar biasa. Perubahan dalam pertemuan korban dan pelaku terjadi seiring mekanisme lingkungan sosial dan kontrol sosial berubah. Kelurahan Damai memiliki tingkat kriminalitas tertinggi di Kota Balikpapan sejak sebelum hingga setelah pandemi COVID-19. Penelitian ini menggunakan SIG dalam memetakan daerah rawan kriminalitas. Analisis selanjutnya mendeteksi indeks Nearest Neighbour untuk mengetahui pola persebaran titik rawan kriminal. Hasil penelitian menunjukkan bahwa secara umum, pola sebaran kriminalitas tetap menyebar sejak sebelum hingga setelah Covid-19. Meskipun demikian, jumlah kriminalitas mengalami peningkatan dengan jumlah tertinggi pada titik waktu setelah Covid-19.
Pemetaan daerah rawan banjir berbasis SIG dan AHP di Perkotaan Singaraja, Bali
Authors: Yastika Putu Edi , Partama I GD Yudha , Aprianto Komang Agus , Untari Anak Agung Mas
Published: July 2024

Singaraja, ibukota Kabupaten Buleleng, Bali, memiliki kondisi geografis dataran rendah sempit dan berbukit yang berpotensi mengakibatkan bencana seperti banjir/banjir bandang dan tanah longsor. Sebagai upaya mitigasi dan pengendalian banjir diperlukan pemetaan potensi rawan bencana untuk menjadi dasar penentuan arah kebijakan dalam pembangunan. Penelitian ini bertujuan untuk memetakan daerah rawan dengan memanfaatkan Sistem Informasi Geografis (SIG) dengan tiga pembeda yaitu (1) penggunaan lahan, (2) kelerengan, dan (3) curah hujan. Data curah hujan dari periode 2018-2022 dikumpulkan dari 5 stasiun/pos pantau milik BMKG. Dari Analytic Hierarchy Process (AHP) diperoleh bobot untuk penggunaan lahan adalah  0,2358, bobot kelerangan sebesar 0,4928, dan bobot pada curah hujan 0,2713. Analisis dengan metode Overlay Intersection pada ArcGIS 10.8 menunjukkan 5,3 km2 (11,9 % wilayah) merupakan area paling rawan banjir, sementara area paling aman seluas 4,06 km2. Hasil pemetaan ini sesuai dengan laporan kejadian banjir ekstrem yang pernah terjadi pada tahun 2018 dan 2021 di daerah-daerah tersebut.
Elaboración de materiales digitales para la docencia Jurídica virtual: relato de una experiencia
Authors: Karina Cicero Nidia , María Parise Carlos
Published: July 2024

El objetivo de este trabajo es relatar el proceso de elaboración de una Carpeta de Trabajo de la asignatura Instituciones de Derecho Público, de formato digital y acceso abierto, que incluye diversos recursos TIC y propuestas de aprendizaje innovadoras. Se ponen a disposición de los lectores un extracto de tres capítulos de la obra.
Extracto carpeta Instituciones de Derecho Público
Authors: Karina Cicero Nidia , Parise Carlos María
Published: July 2024

Se adjunta extracto con los tres primeros capítulos de la obra referenciada
Presentación
Authors: Magaldi Nuria , Bueno Armijo Antonio
Published: July 2024

Presentación del número 21 de la Revista Docencia y Derecho. Monográfico coordinado por Nuria Magaldi y Antonio Bueno Armijo, Profesores Titulares de Derecho Administrativo de la Universidad de Córdoba y directores del International Colloquium on Higher Education in Foreign Languages in Law and Political Sciences.
Unlocking global opportunities: Exploring bilingual teaching in Spanish business law
Authors: González Jiménez Pedro Mario
Published: July 2024

This paper explores the complexities of bilingual teaching in Spanish business law, highlighting both opportunities and challenges. Teaching in English offers global recognition and collaboration, especially in areas like international trade. However, nuances in Spanish commercial law and subjects rooted in national legal traditions, like insolvency law, pose hurdles. Anisomorphism between legal systems complicates direct translations, emphasizing the need for a strategic approach. Despite harmonization through directives, elements shaped by national legislation persist. Scarcity of English teaching materials necessitates ad hoc preparation, impacting educators and student independence. A judicious approach to bilingual teaching is crucial, balancing global benefits with linguistic intricacies and resource challenges.
Diagnosis of the internationalization of teaching Tax Law: Difficulties and suggestions when doing it in english
Authors: López Espejo Julia , Urbano Sánchez Lucía
Published: July 2024

In this paper, a diagnosis of the current degree of the internationalization of teaching Tax Law at the University of Cordoba is conducted and the viability to impart these contents in English is also analysed. Two are the main aims of this paper. The first one is to present the difficulties we detect when teaching these courses in English and the possibilities offered for this purpose by the different compulsory subjects from the various Degrees existing at the Faculty of Law and Economics and Business Studies of the University of Cordoba. Moreover, there is a second aim: to offer new internationalization opportunities through the feasible introduction of optional subjects in the aforementioned Degrees.
Viktoria G. Lysenkoю Review of Indian Philosophers on the Nature of Perception: Dignāga and his opponents. Texts and research
Authors:   HSE University, Kanaeva Nataliya A.
Published: July 2024

Review of Indian Philosophers on the Nature of Perception: Dignāga and his opponents. Texts and research, by Viktoria G. Lysenko
John Milbank and the “Suárez Affair”
Authors:   RAS Institute of Philosophy, Vdovina Galina V.
Published: July 2024

The article focuses on the key concepts of the philosophical theology of Francisco Suárez and the post-Suárezian scholastics. These concepts were used by John Milbank, contemporary English theologian and initiator of the «radical orthodoxy» movement, to historically justify his own views. In Milbank's interpretation, four points define the transition of medieval scholasticism from the “correct” Thomistic understanding to the pernicious innovations of Duns Scotus; through Suarez and his younger contemporaries, according to Milbank, they have been adopted by theologians and philosophers of modernity. The concepts in question are: univocation of being, cognition as a mirror image, potentiality, and “coincidence” (concurrentia). Milbank believes that these concepts have replaced the original ones – analogy, cognition as a formal identity, the primacy of actuality and “influxus”. Milbank's specific work with these notions often looks like a forced subsumption of a range of complex and heterogeneous problems that receive one-sided and even historically incorrect coverage. Such is the subject of this article. Its purpose is to analyze, on the basis of Milbank's views, the textual evidence of the meaning of these concepts and to draw certain conclusions concerning the adequate methodology of modern thinkers' engagement with the scholastic tradition.
Conrad Vogler and His Abridged Version of “Summa de religio” of Francisco Suarez: Evolution of the Meaning of the Term “Religion”
Authors: Lupandin Ivan ,   St. Cyril and Methodius Institute for Postgraduate Studies
Published: July 2024

The article discusses the evolution of the concept of religion from Cicero, who first defined this term, to the era of modern times. The concept of religion by Clement of Alexandria, Augustine, Thomas Aquinas and Francisco Suarez is analyzed. The Greek term “θρησκεία” found in the New Testament and the validity of its translation by the Latin word “religio” (in Jerome’s Vulgate) are discussed. The history of the gradual rooting of the term “religion” in the Russian language is also touched upon (it is shown that the word “religion” begins to be actively used in Russia only from the era of Peter the Great). The appendix contains a translation from Latin of the first two books of the work of the Austrian Jesuit Conrad Vogler (1665–1742) “A Brief Exposition of the Summa on the Religion of Francisco Suarez”, in connection with which a shift towards a legalistic understanding of religion in the theology of the Jesuits is revealed.
Ancient Greek Culture and Buddhism in the Far East of the Hellenistic World
Authors: Burmistrov Sergey ,   Institute of Oriental Manuscripts, Russian Academy of Sciences
Published: July 2024

The topic of the book by Olga Kubica, a professor at the University of Wroclaw, is the interaction between ancient Greek and Indian civilizations in the far East of the Hellenistic world in the epoch from the conquests of Alexander the Great to the emergence of the Kushan Empire. The influence of ancient artistic traditions on the fine arts of northwestern India (the so-called “Gandhāra school”) is well known, and it has been suggested on this basis that the influence of Greece extended to the philosophical and religious views of Indians. It was seen, in particular, in the themes and structure of the early Buddhist treatise “Milinda’s Questions” (Pali Milindapañha). However, the author of the monograph proves that the actual interaction of Greek and Indian cultures in the intellectual sphere was not so large and profound and therefore the term “Greco-Buddhism”, widespread in Oriental studies, has no sense. This conclusion is based on an deep analysis of extensive material, including not only texts, but also archaeological sites, numismatic data and other sources. Analyzing the material, the author uses, along with the usual philological methods of working with sources, also methods of sociology and cultural studies, considering the Greeks in Bactria and northwestern India as a social group that obeys all the laws of behavior of such objects interacting with society as a social system.
“Postsecular”: Renewing the Debate
Authors: Kyrlezhev Alexander ,   Russian Presidential Academy of National Economy and Public Administration
Published: July 2024

The article outlines the idea of “postsecularity,” which has already become traditional in certain areas of religious studies and sociology of religion. On the one hand, it is contested within other research areas, and on the other hand, has not led to the creation of a clear and consistent theory, although it has become very popular in public discussion. In defending his position, the author refers both to his own works on the topic and to a large corpus of texts that to one degree or another touch upon the “post-secular thesis”, including studies devoted to the concepts of “secular” and “religion” in the aspect of their rethinking in modern times. Secularism, understood as an ideology and quasi-religion, and its fate in the modern world are discussed. It is argued that classical European secularization has now ended due to the fact that secularism as a global civilizational project has failed not only in non-Western contexts, but also in zones of active secularization, which took place in European contexts, albeit in different forms – both the ghettoization of religion (in the European West), and the atheism of the entire society (as in countries where the socialist project was being implemented). The new post-secular situation is characterized as the return of religion/religiosity not only to the public sphere, but also to the Lebenswelt of individuals who actualize various forms of religiosity, including the so-called spirituality. Thus, contrary to the standard thesis about secularization, which assumes a decline in people’s religiosity, the modern world demonstrates its new forms, not necessarily associated with long, dominant religious traditions and organizations. The author believes that the concept of a “true believer” as the most conscious, informed and religiously active individual, which has become standard in the science of religion, should be discarded, given that religiosity manifests itself in a variety of forms, far from such rigoristic interpretations. The author’s final thought is that in the current situation, the modern European description (understanding) of religion can no longer be a prescription for religion, that is, a requirement addressed to it, which is one of the aspects of the “post-secular turn”.
Natural science knowledge in civilizational studies
Authors: Aslanov Leonid ,   Lomonosov Moscow State University
Published: July 2024

Modern knowledge of ethology are considered in their application to the problems of local civilizations. Human behavior is determined by innate and acquired patterns of behavior. They correspond to two interconnected parts of each civilization: a culture that correlates to the acquired behavior, and a mentality (self-preservation instinct), referring to the inher­ited behavior and ensuring the constancy of the behavior of the people from generation to generation. The relationship between culture and mentality and the negative conse­quences of imposing an alien culture on people with an ingrained mentality are shown on the example of the organization of labor in the Russian artel. Psychological personality types that are stably inherited are examed, and taking into account them, the role of the Moscow principality in the formation of the Russian state is considered.
“One Belt, one Road” initiative as a way to the mutual peaceful civilization perception
Authors: Airu Chen ,   Academy of Marxism, Chinese Academy of Social Sciences, Xiaoping Zhang ,   Academy of Marxism, Chinese Academy of Social Sciences
Published: July 2024

The Belt and Road Initiative in the new era is not only a mutually beneficial way to promote global economic cooperation, but also a peaceful path to mutual understanding and exchange among civilizations. Participation in the construction of the project helps participants in the international process to understand the civilizational differences between them and build their behavior with an understanding of the global point of view. Thus, this issue is not only of theoretical significance for the development of human civilization, but also from a practical point of view. The new concept of civilization proposed by China, with its enormous energy, is actively promoting a new direction for the development of human civilization.
“Clash of Civilizations” – myth or reality: analytical review of the 21st International Panarin’s readings, February 15, 2024
Authors: Alasania Kira ,   Lomonosov Moscow State University, Moschelkov Evgeniy , Nikandrov Aleksey , Sedykh Tatiana ,   Lomonosov Moscow State University,   Lomonosov Moscow State University,   Lomonosov Moscow State University
Published: July 2024

The article presents an analytical review of the 21st International Panarin’s Readings held on February 15, 2024. The topic of the conference: “Clash of Civilizations”: Myth or Reality? The article describes the contents of the conference: greetings to the participants, the Plenary with a brief summary of the reports, and the reports’ summaries.
Conversation of Acting First Deputy Director of the RAS Institute of Philosophy, Head of the Megatheme “Russian Civilizational Development Project”, Academician Andrey V. Smirnov and the Editor-in-chief of the “Civilization Studies Review”, Sc.D. in Phil
Authors: Shevchenko Vladimir ,   Institute of philosophy RAS, Smirnov Andrey ,   Institute of philosophy RAS
Published: July 2024

The current conversation of the head of the megatheme “Russian civilizational development project” academician Andrey V. Smirnov and the editor-in-chief of the magazine “Civilization Studies Review” Vladimir N. Shevchenko discovers the results of the five-year work of the research group of the Russian Academy of Sciences Institute of Philosophy, and gives a general assessment of the significance of the results obtained for a wide range of academic researchers – philosophers, political and cultural scientists, historians, and for the entire Russian academic community. In particular, important issues of clarifying the initially formulated goals and objectives of the project are raised. The general standards of publications in the journal, created to highlight the scientific results of research on the megatheme, as well as further prospects are discussed. The discussion also covers such problems as compatibility of various methodological approaches used by the authors of published materials, scrutinizes the relations of cultural, political and legal aspects. Significant attention is paid to theoretical views upon the interaction of civilizations in modern conditions, as well as the unique logic of the development of Russian civilization, the connection between “high” and traditional culture in the search for the most adequate expression of the essence of the civilizational project and its practical implementation.
Uterine Artery Embolisation for Adenomyosis in Women Who Failed Prior Endometrial Ablation
Authors: Liang Eisen , Parvez Razeen , Ng Sylvia , Brown Bevan
Published: July 2024

Purpose: To report the effectiveness of uterine artery embolisation (UAE) in treating adenomyosis in women who failed prior endometrial ablation (EA).
Materials and Methods: This is a retrospective cohort study. Medical records of women who had UAE for adenomyosis over a five-year period were reviewed to identify women who had failed prior endometrial ablation (EA). A 2-part electronic survey was sent to these women: Part 1 inquired about changes in menstrual heaviness, period pain, menopausal status, overall satisfaction, and requirement for further intervention. Part 2 consisted of the Uterine Fibroid Symptom and Quality of Life Survey (UFSQoL). Pain score, number of days in pain, MRI uterine volume, junctional zone thickness, and Symptom and QoL scores before and after UAE were compared.
Results: Eighteen women who had undergone EA prior to UAE were identified. One was lost to follow-up, leaving 17 women available for review, with a mean follow-up of 1.6 years (range 0.6 to 3 years). The mean reduction in pain score was 6.29, the mean reduction in symptom score was 32.1, and the mean QoL improvement was 39, all significant (P<0.0001). Improvement in menorrhagia was reported in 7/8 (87.5%) women. Fifteen (88.2%) women were satisfied with the outcome. Only 1/17 (5.9%) women proceeded to hysterectomy. Mean uterine volume reduction was from 189.7 mL to 123.3 mL. Mean junctional zone reduction was from 17.9 mm to 14.0 mm. No complications were noted in this audit.
Conclusion: UAE is effective in managing adenomyosis in women who failed prior endometrial ablation, with significant improvement in dysmenorrhea and heavy menstrual bleeding.
Investigating the factors related to the brain executive function change during pregnancy
Authors: Iranshahi Saeideh , Arab Maliheh , Arabgol Fariba , Shekarriz-Foumani Reza , Nouri Nasim , Ghavami Behnaz
Published: July 2024

Objectives
Some studies indicate cognitive defects during pregnancy, but the factors affecting these defects have not been addressed. Therefore, the present study aims to determine the impressive factors in executive function during pregnancy.
Materials and methods
This study was conducted on pregnant women referred to Imam Hossein and Taleghani Hospital in Tehran between October 2021 and October 2019. Eligible people completed the Brain Executive Function Questionnaire of the adult self-report form at the following three points of follow-up: the first trimester of pregnancy, the third trimester of pregnancy, and postpartum. The executive performance scores of the studied subjects and the influencing factors were reported.
Results
In this study, 210 pregnant women with a mean age of 28.70 ± 7.08 years filled out the questionnaire three times. The Global Executive Composite (GEC) of the study subjects in the third trimester of pregnancy was significantly higher than in the first trimester of pregnancy and after delivery (a higher score indicates a greater impairment of the brain's executive function) which indicates lower executive function during the third trimester. The GEC of the study subjects after delivery was significantly higher than in the first trimester of pregnancy. The level of education of the subjects was the covariance of the changes in the study subjects' executive performance.
Conclusion
Score of the postpartum period in comparison to the first trimester was significantly decreased, yet. Also, the changes in the executive function of the brain during pregnancy were influenced by the level of education including better function and lower decline in the high-educated group.
"They forget that I'm a human being " - ward round communication with older patients living with frailty and informal caregivers: A qualitative study
Authors: Andersen Lene Holst , Loefgren Bo , Skipper Mads , Krogh Kristian , Jensen Rune Dall
Published: July 2024

Purpose
Skilful communication prompts quality patient care. Informal caregivers occupy a crucial role when caring for hospitalised older patients living with frailty. However, skilful communication with both patients and informal caregivers during ward rounds has not been studied. Thus, we aimed to explore communication preferences of patients and informal caregivers during ward rounds.
Methods
We conducted semi-structured interviews with hospitalized patients and informal caregivers until information redundancy occurred. We used inductive coding of the transcribed interviews followed by a reflexive thematic analysis.
Results
The study included 15 patients and 15 informal caregivers. Patients had a median age of 85 years (range 75-100 years) and seven patients were females. Informal caregivers' median age were 45 years (range 38-80 years) and 13 were females. Three themes were generated: 1) Building relationships and conveying information, 2) alleviating informal caregiver strain and 3) sharing the decision-making process. Themes highlighted the importance of collaborative and empathetic approaches in healthcare interactions, emphasizing interpersonal communication skills, such as fostering professional relationships. The interviews unveiled informal caregiver burden stemming from disempowerment during hospital discharge process and managing mistrust within the healthcare system. The shared decision-making process should address patients' and informal caregivers' needs and circumstances.
Conclusion Communication preferences of a population of older patients living with frailty and informal caregivers during ward rounds encompass interpersonal communication, demonstrating ample time, and being seen as a human being. Informal caregivers value being included in the decision-making process. Skilful communication includes for doctors to recognize informal caregivers' narratives and burdens.
A Novel Computational Approach to Assess Microcirculatory Resistance for assessing microcirculatory resistance in patients with non-obstructed vessels
Authors: Bing Ji , Ye Zi , Tong Jing , Gao yanhua , Ping Fan , Lai Yan , Liu Xue bo
Published: July 2024

Background
An intracoronary wire equipped with a transducer and at least 3 to 4 ml of room-temperature saline injected into the coronary artery during prolonged congestion are often used to assess the index of microcirculatory resistance (IMR). This is a time-consuming and expensive procedure.
Methods
With the invasive wire-based IMR serving as the reference standard, this prospective, single-center, randomized study aims to evaluate the diagnostic performance of the novel single-view, pressure-wire- and adenosine-free angiographic microvascular resistance (AMR) index in patients with suspected myocardial ischemia and nonobstructive coronary arteries.
AMR was blindedly and independently computed from the diagnostic coronary angiography. An independent core laboratory determined AMR on-site in real-time and compared it blindly to wire-based IMR, interpreting wire-based IMR of ≥25 units as abnormal coronary microcirculatory resistance. The main outcome, measured against wire-based IMR as a reference, was AMR's diagnostic accuracy.
Using pressure wire-based IMR, 200 patients (200 vessels) were studied. The criteria for microvascular dysfunction (CMD) was IMR ≥ 25. AMR was blindedly and independently computed from the diagnostic coronary angiography.
Results
The mean AMR was 2.44±0.68 and showed good correlation (r = 0.6672, p < 0.001) with IMR. A least-squares fit shows a relationship: AMR=1.8+0.024 IMR (regression coefficient 95% CI: 0.011-0.037, P=0.001). According to microcirculatory status, Two groups were divided: low IMR (<25 U, non-CMD group) and high IMR (≥25 U, CMD group). AMR values were found to be significantly higher in the CMD group than in the non-CMD group (2.78±0.68 vs 2.03±0.40,P=0.004).The AUC for the diagnosis of CMD by ROC curve analysis of AMR was 0.889 (95% CI: 0.707-1.0).
Conclusion
AMR derived from angiographic views is a viable computational alternative to pressure line-based IMR, with good diagnostic accuracy in the assessment of CMD.
A new approach for risk assessment of pulmonary toxicants: a preliminary study using didecyldimethylammonium chloride
Authors: Kim Jun Woo , Han Yu Bin , Chung Kyu Hyuck , Park Yong Joo
Published: July 2024

Recently, interest in alternative toxicity testing methods to reduce the number of animals used in toxicity evaluations has increased. A more accurate approach is required for human risk assessments, which currently uses animal toxicity data to determine point of departure (POD) values and applies uncertainty factors. Therefore, in this study, we propose an approach for an inhalation toxicity risk assessment using in silico and in vitro methods. Human primary alveolar epithelial cells were treated with aerosolized didecyldimethylammonium chloride (DDAC) to determine cytotoxicity, then transcriptome analysis and biological pathway investigation was combined based on adverse outcome pathways (AOPs) to calculate the POD. Human DDAC exposure was simulated using a multiple-path particle dosimetry (MPPD) model to predict the exposure level of human alveolar area to inhalation of DDAC in silico. These in silico and in vitro results were compared, and a risk assessment was performed. The POD for oxidative stress, inflammation, EMT, apoptosis, and autophagy, which are key AOP452 events, were between 19.0 and 23.89 ng/cm2 according to benchmark dose calculation tools. The human exposure to DDAC in alveolar epithelial cells was 0.164 ng/cm2/day, resulting in a margin of exposure (MOE) range of 121–145. This study proposes a novel risk assessment method that involves comparing the exposure of human lung alveolar epithelial cells through inhalation using the human equivalent concentration method through in vitro experiments. This study demonstrated that it is possible to perform human risk assessments using both in silico and in vitro methods.
Automated Assessment of Simulated Laparoscopic Surgical Skill Performance using Deep Learning
Authors: Power David , Burke Cathy , Madden Michael G. , Ullan Ihsan
Published: July 2024

Artificial intelligence (AI) has the potential to improve healthcare and patient safety and is currently being adopted across various fields of medicine and healthcare. AI and in particular computer vision (CV) are well suited to the analysis of minimally invasive surgical simulation videos for training and performance improvement. CV techniques have rapidly improved in recent years from accurately recognizing objects, instruments, and gestures to phases of surgery and more recently to remembering past surgical steps. Lack of labeled data is a particular problem in surgery considering its complexity, as human annotation and manual assessment are both expensive in time and cost, and in most cases rely on direct intervention of clinical expertise. In this work, a newly collected simulated laparoscopic surgical dataset (LSPD) is presented that will initiate the research in automating this problem and avoiding manual expert assessments. LSPD statistical analyses are given to show similarities and differences between different expertise levels (on Stack, Bands, and Tower Skills). In addition, a 3-dimensional convolutional neural network (3DCNN) is used to classify the experience level of the surgeons, novices, and trainees and is found to achieve good results at distinguishing these, with F1 score of 0.91 and AUC of 0.92.
Exploring the effect and mechanism of DaYuan Yin against acute lung injury by Network Pharmacology,molecular docking and experiment validation
Authors: ZHANG Lei , Zhu Wei , Zhang Cong
Published: July 2024

Background: DayuanYin (DYY) is a traditional Chinese medicine (TCM) formula for the treatment of lung diseases.However, the substance and mechanism of its improvement on acute lung injury (ALI) still need to be studied.
Methods: DYY's effective components and potential targets were identified using Traditional Chinese Medicine Systems Pharmacology(TCMSP), and a network of herb-component-targets was created with Cytoscape3.7.2. The target genes for ALI were sourced from GeneCards, DisGeNET, and DrugBank databases. The drug-disease target protein-protein interaction (PPI) network was constructed and core targets were visually identified with Cytoscape. Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) enrichment analysis were conducted using Metscape database.The effective components of DYY were further identified by UHPLC-MS/MS. Subsequently, the therapeutic effect of DYY on ALI and its possible mechanism were studied in LPS-induced ALI rats. Finally, the interaction between nuclear factor erythrocyte 2-associated factor 2(Nrf2), Heme Oxygenase-1 (HO-1), Toll-like receptor 4(TLR4) and active components was evaluated by molecular docking.
Results: A total of 95 active compounds, 234 potential therapeutic targets and 2529 ALI related target genes were obtained. DYY and ALI share a target number of 111. KEGG analysis showed that the PI3K-AKT and MAPK signaling pathways and their mediated oxidative stress pathways are closely related to ALI, which may be the potential mechanism of DYY anti-ALI. Network pharmacology and UHPLC-MS/MS analysis showed that the active ingredients included quercetin, OroxylinA, Magnolol, Wogonin, Glabrone, Honokiol and LicochalconeA. Animal experiments have shown that DYY can reduce the lung wet-to-dry (W/D) ratio, the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in bronchoalveolar lavage fluid (BALF), and the contents of malondialdehyde (MDA), nitric oxide (NO) and reactive oxygen species (ROS) in lung tissue of LPS-treated rats. It is worth noting that DYY promotes the expression of Uncoupling protein 2 (UCP2) mRNA in vivo, increases the expression of Nrf2 and HO-1, and then inhibits the pro-inflammatory mediators mediated by TLR4. Molecular docking analysis showed that the main components of DYY had strong binding ability with HO-1.
Conclusions: This study shows that DYY can alleviate inflammation, oxidative stress and pathological changes of ALI by targeting Nrf2/HO-1 mediated TLR4 signaling pathway, which has important implications for developing effective ALI treatments.
“It’s within your own power”: Shared Decision-Making to Support Transitions to Buprenorphine
Authors: Williams Beth E. , Martin Stephen A. , Hoffman Kim A. , Andrus Mason D. , Dellabough-Gormley Elona , Buchheit Bradley M.
Published: July 2024

Introduction:
Buprenorphine is an effective first-line treatment for opioid use disorder (OUD) that substantially reduces morbidity and mortality. For patients using illicitly-manufactured fentanyl (IMF), however, transitioning to buprenorphine can be challenging. Evidence is lacking for how best to make this transition in the outpatient setting. A shared decision-making (SDM) approach has been found to benefit patients with OUD but has not been studied for buprenorphine initiation. We sought to explore participants’ experiences with a SDM approach to buprenorphine initiation.
Methods:
Participants were beginning care at a low barrier, telehealth buprenorphine clinic. Clinicians implemented a standardized SDM approach whereby they offered patients using IMF four options for buprenorphine initiation (traditional, rapid low-dose, standard low-dose, and QuickStart). They elicited patient goals and preferences and discussed the pros and cons of each method to come to a shared decision. Patients meeting study criteria were invited to participate in semi-structured qualitative interviews 1-2 weeks after the initial visit. Interviews focused on experiences with the clinical visit, suggestions for enhancing the treatment experience, and patient factors affecting the method they chose. Interviews were coded and analyzed using reflexive thematic analysis.
Results:
Twenty participants completed interviews. Participants’ mean age was 33, they were 50% female, predominantly White (16 [80%]), and most had Medicaid insurance (19 [95%]).
Three themes emerged. First, participants found SDM acceptable and a positive addition to their OUD treatment. They felt their opinion mattered and reported that SDM gave them important control over their care plan. Second, patient goals, preferences, and past experiences with buprenorphine-associated withdrawal impacted what type of buprenorphine initiation method they chose. Finally, participants had advice for clinicians to improve SDM counseling. Participant recommendations included ensuring patients are informed that withdrawal (or “feeling sick”) can occur with any initiation method, that buprenorphine will eventually “block” fentanyl effects once at a high enough dose, and that clinicians provide specific advice for tapering off fentanyl during a low dose initiation.
Conclusions:
Shared decision-making is an acceptable approach to buprenorphine initiation in the outpatient setting. It can enhance patient autonomy and lead to an individualized approach to OUD care.
Detection of Rickettsia spp. in questing ticks (Acari: Ixodidae) from forest fragments adjacent to agricultural and livestock farms in Casanare, Colombia
Authors: Rodríguez-Bautista José Luis , Fuya-Oviedo Patricia , Nijhof Ard Menzo , Chitimia-Dobler Lidia , Obara Isaiah , Fonseca Adivaldo
Published: July 2024

This study aimed to describe the diversity of ixodid tick species in rural forest areas of Yopal and Aguazul, Department of Casanare, Colombia, and to evaluate the presence of tick-borne Rickettsia sp., potentially impacting animal and human health. A cross-sectional study was conducted on questing ticks collected from forested farm areas that keep livestock and/or conduct agricultural activities. All ticks were subjected to DNA extraction and tested by PCR amplifying fragments of three rickettsial genes: gltA, htrA, and ompA. A total of 852 individual ticks (larvae, nymphs, and adults) and 15 additional larvae clusters were collected and identified as Amblyomma mixtum, Amblyomma cf. parvum, Amblyomma dissimile, Amblyomma spp., and Dermacentor spp. Rickettsia organisms were detected by PCR in 7.0% (16/230) of the individual larvae, 0.2% (1/488) of the nymphs, and 1.5% (2/134) of the adults. “Candidatus Rickettsia colombianensi” and Rickettsia amblyommatis were detected in 1.52% (13/852) and 0.47% (4/852) of the ticks, respectively. In addition, a novel genotype, Rickettsia sp. genotype Yopal, phylogenetically closest to Rickettsia canadensis, was identified in two A. mixtum males. Several tick and Rickettsia species were found in the study areas, suggesting the need for an in-depth study of rickettsiosis in the Department of Casanare and across Colombia. Priority areas for future studies include investigating the molecular, clinical, and epidemiological features of the presentation of tick species and the possible participation of “Ca. R. colombianensi”, R. amblyommatis, and “Rickettsia sp. Yopal genotype of A. mixtum” to understand their role in human rickettsiosis in the study region.
Space-based inversion tracks and attributes Shanxi's under-estimated carbon monoxide emissions
Authors: Cohen Jason , Li Xiaolu , Tiwari Pravash , Wu Liling , Wang Shuo , He Qin , Yang Hailong , Qin Kai
Published: July 2024

A space-based mass-conserving framework using observed carbon monoxide (CO) and formaldehyde (HCHO) columns quantifies day-to-day and grid-to-grid CO emissions over energy-consuming Shanxi. Annualized total emissions are 8 times higher than a priori datasets, especially over low emission areas, resulting in an at least 7% increase in CO2 emissions. Significant forcings include atmospheric lifetime of CO (0.3–16.5 d) and HCHO (0.1-6.5h), and transport. Annual CO emissions decreased year-by-year, although this is only obvious when considering the two to three highest months. The ratio of top-down CO to NOx emissions show source attribution is possible over rural, urban, and five industrial areas (including power, iron/steel, and coke). Cross-border transport of CO is important in the peak emission months, including evolving sources from central Shaanxi and western Hebei. The major reason for the significant increase CO emissions is the fractional increase in non-high emitting area’s energy consumption, resulting in a spatial mis-alignment.
Sedative Effects of Dexmedetomidine in Combination with Propofol in Patients with Atrial Fibrillation Undergoing Electrical Cardioversion following Catheter Ablation
Authors: Liu Chao , Peng Rongbing , li Xiaolong , Yu Manli , Guo Zhifu
Published: July 2024

Background
To observe the safety and effectiveness of sedation in patients with atrial fibrillation (AF) undergoing electrical cardioversion following catheter ablation using a combination of propofol and dexmedetomidine (P-D group) versus propofol alone (P group).
Methods
A total of 120 AF patients undergoing electrical cardioversion post-catheter ablation were enrolled from October 2020 to August 2022. They were randomly assigned to either the observation group (P-D group) or the control group (P group), with 60 patients in each group. Vital signs, adverse events, analgesic effects, and awakening time were assessed at different stages (T0-T4) in both groups.
Results
In P-D group, HR was lower than T0 in T1-4, the MAP and SpO2 began to decreased in T2-3.In P group, SpO2, HR and MAP in T2-4 were all inferior to baseline period of T0. Whereas, in P-D group, the descend range of MAP and SpO2 of T2, and the SpO2 of T3 were distinctly less than the P group. The adverse events including respiratory depression and bradycardia in P-D group were inferior to the P group (16.7% vs 40% P = 0.045; 13.3% vs 3.3%; P = 0.35). The satisfaction of analgesia in P-D group was apparently prominent than P group (93.3% vs 73.3%;P < 0.05).
Conclusion
In AF patients requiring electrical cardioversion, the combination of propofol and dexmedetomidine demonstrates good sedative and analgesic effects, significantly reducing the propofol dosage and lowering the incidence of clinical adverse events, thereby enhancing medication safety.
Green synthesis of silver nanoparticles using Kenaf leaves extract and their antibacterial potential in acne management.
Authors: Ong Wei Ting Jess , Yeap Swee Pin , Haque Jahurul , Nyam Kar Lin
Published: July 2024

Acne vulgaris affects approximately 9.4% of the world population and was ranked 8th most prevalent disease. Concurrently, silver nanoparticles (AgNPs) are widely explored for their profound antibacterial properties which are ideal for acne management. With the current search for natural alternatives in both cosmetics and nanotechnology, plant extracts have garnered tremendous attention in the synthesis of AgNPs. Therefore, this study utilized Kenaf leaves extract (KLE) as a novel, natural reducing agent for the synthesis of AgNPs. The effects of different synthesis parameters were studied and KLE-synthesised AgNPs (KLE-AgNPs) were further analysed for their physicochemical properties and antimicrobial efficiency. Results showed that small-sized (60.32±2.41nm), stable (-43.03±2.55 mV) and monodispersed (0.28±0.01) KLE-AgNPs were successfully formed with 3mM silver nitrate, and 3mg/mL KLE along with the optimal conditions at pH 11, 48 hours incubation time, reaction temperature of 37°C, and centrifugation at 10000g for purification. FTIR analysis confirmed the presence of functional groups that aid in the formation of AgNPs. Additionally, XRD result demonstrated that KLE-AgNPs recorded crystalline size of 58.59nm. The FESEM and EDX analyses displayed that the particles were spherical and silver was the main element respectively. The antimicrobial analysis proved that a lower dose of KLE-AgNPs demonstrated better antimicrobial effect on the three acne-causing bacteria compared to commercial AgNPs and chemically synthesized-AgNPs. The outcome of this research amplifies the role of KLE as a natural reducing agent in the synthesis of AgNPs for the development of hybrid nanocosmetics with increased efficacy due to the synergistic effect of KLE and AgNPs.
Phytochemical Changes in Ginseng (Withania somnifera) Hairy Roots with Endophytic Fungi
Authors: Soltaninejad Nasibeh , Sadat-Noori Seyed Ahmad , Izadi-Darbandi Ali , Amini Fatemeh , Mirjalili Mohammad hossein
Published: July 2024

Withania somnifera is of high medicinal importance due to the presence of the anti-cancer substance withanolide. The southern regions of Iran are suitable for growing this plant. Growth, physiology, and production of phytochemicals in hairy roots are significantly influenced by biological elicitors such as endophytic fungi. The best strain for hairy root induction was the A4 strain. The purpose of this study was to investigate the effect of three strains of endophytic fungi extracted from the roots of W. somnifera (Aspergillus lentulus, Chaetomium sp, Ascochyta rabiei) on Growth, physiology, and production of phytochemicals in hairy roots of this plant. The treatments included 3 strains of endophytic fungi at 24, 48, and 72 hours and in two concentrations of 10 and 20 mg in one cc of culture medium. The experiment was conducted as a factorial in a completely randomized design with 3 replications. All 3 strains increased the growth index and increased the activity of enzymes and phytochemicals. Chaetomium sp strain showed higher fresh weight (4.05 times the increase compared to the control) and higher dry weight (1.59 times the increase compared to the control). The strain of A. lentulus greatly increased the activity of phytochemical enzymes, and the strain of A. rabiei increased the amount of protein (1.76 times) in hairy roots compared to the control.
Induction of territorial behavior and dominance hierarchies in laboratory mice
Authors: Battivelli Dorian , Boldrini Lucas , Jaiswal Mohit , Patil Pradnya , Torchia Sofia , Engelen Elizabeth , Spagnoletti Luca , Kaspar Sarah , Gross Cornelius T.
Published: July 2024

Territorial behaviors comprise a set of coordinated actions and response patterns found across animal species that promote the exclusive access to resources. House mice are highly territorial with a subset of males consistently attacking and chasing competing males to expel them from their territories and performing urine marking behaviors to signal the extent of their territories. Natural variation in territorial behaviors within a mouse colony leads to the formation of dominance hierarchies in which subordinate males can reside within the territory of a dominant male. While the full repertoire of such territorial behaviors and hierarchies has been extensively studied in wild-derived mice in semi-natural enclosures, so far they have not been established in the smaller enclosures and with the genetically-defined laboratory strains required for the application of neural recording and manipulation methods. Here, we present a protocol to induce an extensive repertoire of territorial behaviors in small enclosures in laboratory mice, including a method for the simultaneous tracking of urine marking behavior in mouse pairs. Using this protocol we describe the emergence of robust dominant-subordinate hierarchies between pairs of CD1 outbred or CD1xB6 F1 hybrid mice, but unexpectedly not in C57BL/6 inbred animals. Our behavioral paradigm opens the door for neurocircuit studies of territorial behaviors and social hierarchy in the laboratory.
Endourological treatment of ureteral strictures with the use of self-expanding stents: is it possible to completely cure the stricture endoscopically? A report on the experience with implantation of 35 stents with a two-year follow-up period; a retrospect study
Authors: Kowalski Filip , Kuffel Błażej , Późniak Michał , Lipowski Pavel , Czarnogorski Michal , Wilamowski Jacek , Ostrowski Adam , Adamowicz Jan , Drewa Tomasz
Published: July 2024

Background:
The current results of endoscopic treatment of ureteral strictures are characterized by very divergent treatment results, which is due to a wide range of criterion for including patients in the analyses and different definitions of effective treatment. In this retrospect study we wanted to introduce a possibility of curing ureteral strictures depending on their type and degree with the use of self-expanding ureteral stents (SUS).
Methods:
33 patients with ureteral strictures received endourological treatment with the use of Allium® SUS (2 patients with SUS placed on both sides). Patients were divided into 2 groups: patients with uncomplicated strictures (Grp 1) and patients with complicated strictures (Grp 2). Uncomplicated stricture was defined as a single stricture below 2 cm. A complicated stricture was defined as a stricture over 2cm and/or as multiple strictures. The follow-up time was 24 months. All patients were scheduled for renoscyntygraphy during the treatment. A full therapeutic success was defined as no tight stenosis in renoscyntygraphic examination after SUS explantation.
Results:
In Grp 1, full therapeutic success was achieved in 80% of patients, which was statistically significant (p < 0.001) compared to Grp 2. Serious complications (Clavien-Dindo > 3a) occurred significantly more often in Grp 2 (p = 0.046). Renal outflow during stenting was present in 70% of the patients in Grp 2.
Conclusions:
A full therapeutic success of endoscopic SUS-assisted treatment can be achieved in patients with a short, single ureteral stricture. In long and/or multiple strictures SUS can be used as drainage element.
Efficient removal of Congo red and cytotoxicity evaluation of biosorbents prepared from chitosan-added watermelon pulp
Authors: Bingöl Mehmet Semih
Published: July 2024

Biosorbents were prepared by lyophilizing chitosan-added watermelon pulp (AC-WPC). The prepared biosorbents were characterized by BET, SEM, Zeta Potential and FT-IR analysis. Accordingly, BET surface areas of AC-WPC was 120.92 m2/g, respectively. SEM analysis showed that the structures were porous and the results were consistent with the BET analysis. FT-IR analysis confirmed the chemical structures. The isoelectric points of the biosorbents were determined by zeta potential analysis. The AC-WPC biosorbent demonstrated 86% cell viability with cytotoxicity testing. For this reason, it was determined that the AC-WPC produced does not cause any serious damage to the cell. A study was carried out on the removal of Congo red textile dye in wastewater by the prepared biosorbents. Langmuir and Freundlich isotherms were studied in adsorption studies and Freundlich isotherm was found to be compatible. Pseudo First and Second kinetic models were also studied. The highest adsorption capacity was observed at 100 mg/l Congo red concentration with 98.02% removal and 490.1 mg/g adsorption capacity with AC-WPC. It is thought that these results will potentially contribute to the literature on the removal of textile dyes or other pollutants using chitosan-added watermelon pulp.