bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of probiotic lactobacilli as alternative to monensin in beef feedlot cattle
Authors: Mansilla Flavia Ivana , Miranda María Hortencia , Ficoseco Cecilia Aristimuño , Obregozo Mariano , Villar Marcela D´Urso , Fátima Nader-Macias María Elena , Vignolo Graciela Margarita
Published: March 2024

In an effort to substitute antibiotics in high-energy diets fed to feedlot cattle, probiotics have emerged as a viable alternative. In this study, increase of animals body weight (BW) and average daily gain (ADG) were used as indicators of probiotics Limosilactobacillus (L.) fermentum CRL2085 and L. mucosae CRL2069 (108–109 CFU/g) supplementation (individually or combined) to grain-based diets containing or not monensin during different periods of feedlot fattening cycle. Results showed that the greatest cattle BW (116.6 kg) and ADG (1.19 ± 0.17 kg/animal/day) were achieved when CRL2085 probiotic was individually supplied during 56 days (after adaptation period) in the absence of monensin (p < 0.01). In the presence of monensin, reduced BW and ADG mean values were obtained during the whole feedlot cycle (98 days) by probiotics supplementation. Thus, L. fermentum CRL2085 probiotic strain administered to feedlot cattle fed diets without monensin may result in a greater cumulative BW and ADG with a shorter administration time comparing with diets containing the ionophore.
Esterification Reaction of Glycerol to The Derivatives Catalyzed by Amberlyst 36
Authors: Aisyah Aisyah , Rezeki Rezeki , Firnanelty Firnanelty , Abubakar A. Nur Fitriani , Zahra Ummi , Patunrengi Iswadi Ibrahim , Nur Arfiani
Published: March 2024

Several studies reported the use of acid catalysts of esterification of glycerol to acetin derivatives and amberlysts are no exception. However, among these strong sulfuric acid catalysts, amberlyst 36 is still rarely used and hence challenging to investigate. This study aimed to determine the yield and the selectivity of the esterification reaction of glycerol into acetine derivatives using a 5% of solid catalyst amberlyst 36 at a temperature of 90°C in a reflux system. The conversion value resulting from the reaction was 80.74%, with a selectivity value of 6.8% for triacetin. FTIR and GC-MS data support the monoacetin and triacetin structures. The findings indicate that the simple method and easily obtained catalyst can produce a high yield of acetin derivatives. This method is still possibly optimized to perform maximum yield with high selectivity.
Synthesis Optimation and Characterization of κ-Carrageenans from Eucheuma cottonii
Authors: Nurlaida Nurlaida , Saadatul Husna , Aswar Aswar
Published: March 2024

The objectives of the study are to determine the best condition for Eucheuma cottonii, obtained from Bantaeng regency, to produce κ-Carrageenan and to determine the characteristics of the carrageenan. Concentration of NaOH and KCl that are used to extract carrageenan, extraction time, and precipitation time are some variables that are measured for carrageenan extraction. After the best extraction condition is found, then the next step is characterization of the produced carrageenan. The best combination found to extract the highest amount of carrageenan are NaOH 4%, extraction time of 1 hour, KCl 6%, and precipitation time of 1 hour as well. For the characterization of ash, fiber, sulfate content, and viscosity are 2.24%; 0.65%; 0.35%; and 5 cP respectively.
Antiseptic Liquid Soap from Corn Oil (Zea mays L) and Aloe Vera Extract with The Variation of SLS (Sodium Lauryl Sulfate)
Authors: M Aras Neny , Santi Santi , Riska Amaliah Nur , Isma Isma , Yusriadi Yusriadi
Published: March 2024

Liquid soap is a cleaning agent made from a chemical reaction between potassium hydroxide and fatty acids from vegetable oils and animal fats. This study aims to determine the quality and formulation used in making antiseptic liquid soap from aloe vera with the variation of Sodium Lauryl Sulfate (SLS). Previous research on making liquid soap from aloe vera produced soap with free alkaline levels and a high pH and still lacking foam. In this study, liquid soap was made by adding variation of SLS (Sodium Lauryl Sulfate), as a foam booster and citric acid as a substance that can control the pH of the soap. The resulting liquid soap product was analyzed for pH value, foam stability, free alkali content/FFA, viscosity, density, ALT and bacterial test. The results showed that each soap formula produced match with the requirements of SNI 2588-2017 and the best formulation is the F2.
HUBUNGAN ANTARA QUALITY OF WORK LIFE DENGAN KINERJA GURU HONORER SMK NEGERI DI KOTA SURAKARTA
Authors: Hutnikanari Seraf , Siswandari Siswandari , Hamidi Nurhasan
Published: March 2024

Abstract

Thiswresearch aimsSto determine the correlation of digital literacy on the teachers competence of industrial revolution 4.0 at Surakarta Vocational School. This type of research is quantitative correlational. The population in this research were students in grade XII of accounting skills program in Surakarta vocational school. The.sampleiused in this research was 228 students with a sampling technique using proportional random sampling. Data collection was carried out using a questionnaire. Analysis of the databused in this research is theecorrelationotest and simple regressiomtest. The results showedmthat there was anpositive and significant correlation between digital literacy on teachers competence in the industrial revolution 4.0.

Keywords: Digital Literacy, Teacher Competence, Industrial Revolution 4.0

 

Abstrak

Penelitian ini bertujuan untuk mengkaji hubungan antara literasi digital terhadap kompetensicguruEeraArevolusiIindustri 4.0 di SMK Surakarta. Jenisppenelitian iniaadalah kuantitatif korelasional. Populasiwdalam penelitian ini adalahnsiswa kelas XII program keahlian akuntansi SMK Se-Surakarta Sampelddalamppenelitianiinissejumlah 228 siswa yang diambil dengannteknik proportional random sampling.nPengumpulan data dilakukan dengan menggunakanmkuesioner. Analisis data yang digunakan dalam penelitian ini adalah korelasi dan regresi sederhana. Hasil penelitianmmenunjukkan terdapat hubungan yang positif dan signifikan antara literasi digital dengan kompetensi guru era revolusinindustri 4.0.

Kata Kunci : Literasi Digital, Kompetensi Guru, Era Revolusi Industri 4.0

 
TINGKAT KNOWLEDGE SHARING MAHASISWA DIUKUR DENGAN INSTRUMEN KNOWLEDGE SHARING BEHAVIOR SCALE
Authors: Romadhoni Wulan , Sumaryati Sri , Muchsini Binti
Published: March 2024

ABSTRACT

           The purpose of this study was to determine the level of knowledge sharing of students of Accounting Education at Sebelas Maret University. This research is a quantitative survey research with descriptive statistical data analysis techniques. The population in this study were all active students of the Sebelas Maret University Accounting Education Study Program in the 2018-2020 class, totaling 247 students. The sampling technique used is proportional random sampling with a sample of 149 students. The data collection technique used is a questionnaire. This study measures the level of knowledge sharing using the Knowledge Sharing Behavior Scale (KSBS) instrument from Yi (2009) with indicators of written contribution, organizational communication, personal interaction, and community practice. The conclusion of this study is that the level of knowledge sharing of students of Accounting Education at Sebelas Maret University can be categorized as poor. This refers to the TCR result of 63.49%. The implication of this research is that lecturers in the learning process can provide more support to all students and create a classroom atmosphere that supports knowledge sharing behavior. Students must also be aware of the importance of knowledge sharing behavior so that learning objectives can be achieved.

 

Keywords: knowledge sharing level, KSBS, written contribution, organizational communication, personal interaction, community practice

ABSTRAK

Tujuan penelitian ini untuk mengetahui tingkat knowledge sharing mahasiswa Pendidikan Akuntansi Universitas Sebelas Maret. Penelitian ini merupakan penelitian kuantitatif survei dengan teknik analisis data statistik deskriptif. Populasi dalam penelitian ini adalah seluruh mahasiswa aktif Program Studi Pendidikan Akuntansi Universitas Sebelas Maret angakatan tahun 2018-2020 yang berjumlah 247 mahasiswa. Teknik sampling yang digunakan adalah proportional random sampling dengan sampel sejumlah 149 mahasiswa. Teknik pengumpulan data yang digunakan adalah angket. Penelitian ini mengukur tingkat knowledge sharing menggunakan instrumen knowledge sharing behavior scale (KSBS) dari Yi (2009) dengan indikator kontribusi tertulis, komunikasi organisasi, interaksi pribadi, dan komunitas praktik. Kesimpulan penelitian ini adalah tingkat knowledge sharing mahasiswa Pendidikan Akuntansi Universitas Sebelas Maret, dapat dikategorikan kurang baik. Hal tersebut mengacu pada hasil TCR sebesar 63,49%. Implikasi dalam penelitian ini, dosen dalam proses pembelajaran dapat lebih memberikan dukungan kepada semua mahasiswa dan menciptakan suasana kelas yang mendukung perilaku knowledge sharing. Mahasiswa juga harus sadar mengenai pentingnya perilaku knowledge sharing agar tujuan pembelajaran dapat tercapai.

 

Kata Kunci: tingkat knowledge sharing, KSBS, kontribusi tertulis, komunikasi organisasi, interaksi pribadi, komunitas praktik

 
PENGARUH KARAKTER WIRAUSAHA, LINGKUNGAN SOSIAL, DAN PERSONAL FINANCE TERHADAP INTENSI BERWIRAUSAHA
Authors: Ningsih Rini Dwi , Susilaningsih Susilaningsih , Susanti Asri Diah
Published: March 2024

Abstract

 

This study aims to determine 1) the effect of entrepreneur character on entrepreneurial intention; 2) the effect of social environment on entrepreneurial intention; 3) the effect of personal finance on entrepreneurial intention; and 4) the effect of entrepreneurial character, social environment, and personal finance on entrepreneurial intention. This study uses quantitative methods with a population of students of SMK class X, XI, XII all majors. Sampling was done by proportionate stratified random sampling with a total of 227 students. Data were collected using a questionnaire distributed online and then the data wa analyzed using multiple linier regression analysis techniques.

The results obtained conclusions 1) entrepreneur character has no significant effect on entrepreneurial intention; 2) social environment has positive and  significant effect on entrepreneurial intention; 3) personal finance has no significant effect on entrepreneurial intention; and 4) simultaneously entrepreneur character, social environment, and personal finance have positive and significant effect on entrepreneurial intention. The three predictors together can affect the entrepreneurial intention with a percentage of 41,4% and 58,6% are affected by other predictors that are outside the variables of this study.
 Keywords: entrepreneur character, social environment, personal finance, entrepreneurial intention

 

Abstrak

 

Penelitian ini bertujuan untuk mengetahui 1) pengaruh karakter wirausaha terhadap intensi berwirausaha; 2) pengaruh lingkungan sosial terhadap intensi berwirausaha; 3) pengaruh personal finance terhadap intensi berwirausaha; dan 4) pengaruh karakter wirausaha, lingkungan sosial, dan personal finance terhadap intensi berwirausaha. Penelitian ini menggunakan metode kuantitatif dengan populasi siswa SMK kelas  X, XI, XII semua jurusan. Pengambilan sampel dilakukan secara proportionate stratified random sampling dengan jumlah 227 siswa. Pengambilan data dilakukan dengan menggunakan kuesioner yang disebar secara online kemudian data tersebut dianalisis menggunakan teknik analisis regresi linier berganda.

Hasil penelitian diperoleh simpulan 1) karakter wirausaha tidak berpengaruh secara signifikan terhadap intensi berwirausaha; 2) lingkungan sosial memiliki pengaruh positif dan signifikan terhadap intensi berwirausaha; 3) personal finance tidak berpengaruh secara signifikan terhadap intensi berwirausaha; dan 4) secara simultan karakter wirausaha, lingkungan sosial, dan personal finance memiliki pengaruh positif dan signifikan terhadap intensi berwirausaha. Ketiga prediktor secara bersama-sama dapat memengaruhi intensi berwirausaha dengan persentase sebe sar 41,4% dan 58,6% dipengaruhi oleh prediktor lain yang berada di luar variabel penelitian ini.

 

Kata kunci: karakter wirausaha, lingkungan sosial, personal finance, intensi berwirausaha

 
PENGARUH PENERAPAN MODEL FLIPPED CLASSROOM BERBANTUAN MEDIA EDPUZZLE TERHADAP HASIL BELAJAR AKUNTANSI SISWA SMK
Authors: Salachima Vembi De , Siswandari Siswandari , Jaryanto Jaryanto
Published: March 2024

ABSTRACT This research aims to examine the difference in the effect of the application of the flipped classroom model with the flipped classroom model associated with edpuzzle media on the accounting learning outcomes on X Vocational High School. This study used quasi-experiment. The population in this study were all students of class X Accounting at SMK X, with a total of 108 students.  The sample used in this study was class X AKL 1 and X AKL 3 with cluster random sampling technique. The result shows that there was a difference in the effect of application of the flipped classroom model with the flipped classroom model associated with edpuzzle media on the accounting learning outcomes of X Vocational High School. The existence of this difference in influence is indicated by the results of the independent sample ttest which obtained a significance of 0.000, meaning sig. < 0.05. The results of the N-gain test showed that the group that applied the flipped classroom model associated with edpuzzle media obtained an average score of 0.74. Based on this, it can be concluded that the application of the flipped classroom model associated with edpuzzle media has a high influence on student learning outcomes. Keywords: Flipped classroom, Edpuzzle Media, Learning Outcomes ABSTRAK Penelitian ini bertujuan untuk mengkaji perbedaan pengaruh penerapan model flipped classroom dengan model flipped classroom berbantuan media edpuzzle terhadap hasil belajar akuntansi siswa kelas X SMK X. Jenis penelitian ini adalah eksperimen semu. Populasi dalam penelitian ini adalah siswa kelas X Akuntansi SMK X dengan jumlah 108 siswa. Sampel yang digunakan pada penelitian ini adalah kelas X AKL 1 dan X AKL 3 dengan teknik cluster random sampling. Hasil penelitian menunjukkan bahwa terdapat perbedaan pengaruh penerapan model flipped classroom dengan model flipped classroom berbantuan media edpuzzle terhadap hasil belajar akuntansi siswa kelas X SMK X. Adanya perbedaan pengaruh ini ditunjukkan dengan hasil uji independent sample t-test yang memperoleh signifikansi 0,000, artinya sig. < 0,05. Hasil uji N-gain menunjukkan bahwa kelompok yang menerapkan model flipped classroom berbantuan media edpuzzle memperoleh skor rata-rata sebesar 0,74. Berdasarkan hal tersebut, dapat disimpulkan bahwa penerapan model flipped classroom berbantuan media edpuzzle memberikan pengaruh yang tinggi terhadap hasil belajar siswa.  Kata Kunci : Flipped Classroom, Media Edpuzzle, Hasil Belajar
PERBEDAAN KEMANDIRIAN ANAK USIA 4-5 TAHUN DITINJAU DARI STATUS PEKERJAAN ORANG TUA
Authors: Wahyuni Sri Umi Ayu , Pudyaningtyas Adriani Rahma , Jumiatmoko Jumiatmoko
Published: March 2024

Kemandirian pada anak yaitu keterampilan anak untuk memiliki inisiatif dalam merencanakan dan mengatur perilaku dalam melakukan kegiatan sehari-hari sesuai dengan perkembangannya.  Anak yang mandiri dapat membantu dirinya untuk tidak banyak bergantung dengan orang lain. Penelitian ini bertujuan untuk melihat perbedaan kemandirian anak usia 4-5 tahun ditinjau dari status pekerjaan orang tua. Status pekerjaan orang tua diduga menjadi salah satu faktor yang mempengaruhi kemandirian anak. Jenis penelitian menggunakan metode kuantitatif dengan jenis penelitian komparasi. Peneliti membatasi masalah pada perbedaan kemandiriian anak usia 4-5 tahun ditinjau dari status pekerjaan orang tua. Kategori orang yang bekerja sendiri yaitu melakukan pekerjaan selama 1 jam berturut-turut selama satu minggu untuk memperoleh pendapatan. Teknik pengambilan sampel menggunakan Simple random sampling. Sebanyak 40 anak dengan ayah dan ibu bekerja serta 52 anak dengan ayah bekerja dan ibu tidak bekerja sehingga total sampel yang digunakan sebanyak 92 anak. Data yang sudah terkumpul selanjutnya dilakukan uji prasyarat analisis. Uji normalitas menggunakan Kolmogorov Smirnov  dan uji homogenitas menggunakan Levene test. Perhitungan uji tersebut dilakukan dengan bantuan SPSS 25 for windows. Hasil hipostesis menunjukkan bahwa nilai signifikan menunjukkan angka 0,034. Nilai signifikan 0,034 < 0,05 sehingga dapat disimpulkan bahwa Ha diterima dan H0 ditolak sehingga terdapat perbedaan kemandirian anak usia 4-5 tahun ditinjau dari status pekerjaan orang tua.
IMPLEMENTASI DEVELOPMENTALLY APPROPRIATE PRACTICE (DAP) PADA STIMULASI KEMAMPUAN MENULIS PERMULAAN ANAK
Authors: Dhida Tasya Tsamara , Hafidah Ruli , Jumiatmoko Jumiatmoko
Published: March 2024

Kemampuan menulis permulaan anak usia dini merupakan wadah mengeksplorasikan pengetahuan dan pengalaman anak yang ditandai dengan tingkah laku mencoret-coret dan menggambar bebas. Salah satu pendekatan yang dapat diimplementasikan untuk mengembangkan kemampuan menulis permulaan adalah Developmentally Appropriate Practice (DAP). Penelitian ini bertujuan untuk mendeskripsikan implementasi DAP pada stimulasi kemampuan menulis permulaan anak usia 4-5 tahun di PAUD Nurul Hidayah Program Khusus. Penelitian ini merupakan deskriptif kualitatif dengan pendekatan studi kasus. Sumber data penelitian ini meliputi kegiatan pembelajaran yang berkaitan dengan stimulasi kemampuan menulis permulaan anak, guru kelas kelompok A sebagai informan, hasil dan proses anak kelompok A melakukan indikator kemampuan menulis permulaan, dan dokumen (RPPM, RPPH, dokumentasi pembelajaran, penilaian, dan dokumen hasil karya). Pengumpulan data dilakukan menggunakan teknik observasi non partisipan, wawancara mendalam, dan analisis dokumentasi. Hasil penelitian ini adalah sebagai berikut, dalam mengimplementasikan DAP untuk menstimulasi kemampuan menulis permulaan anak melalui tiga tahapan yaitu pra implementasi, implementasi, dan pasca implementasi. Pertama, pra implementasi mencakup pembahasan dan perencanaan kegiatan yang dituangkan dalam dokumen perangkat pembelajaran. Kedua, implementasi mencakup pelaksanaan kegiatan stimulasi dan pembelajaran. Ketiga, pasca implementasi mencakup penilaian, evaluasi, dan refleksi. Implementasi DAP dalam menstimulasi kemampuan menulis permulaan sangat sesuai diterapkan karena ramah anak, menyesuaikan capaian, dan tahapan perkembangan anak.
EFEKTIVITAS PENGGUNAAN EMOTION DIARY SEBAGAI STRATEGI UNTUK MENINGKATKAN REGULASI EMOSI PADA ANAK
Authors: Tito Hanna Theodora , Syamsuddin Muhammad Munif , Sholeha Vera
Published: March 2024

Emosi merupakan pusat dalam kehidupan manusia. Sejak usia dini anak-anak sudah menunjukkan berbagai emosi dalam situasi sosial melalui pesan non verbal (misalnya menangis, berteriak, memukul). Untuk mengelola emosi yang kuat ini, anak-anak perlu belajar bagaimana mengatur emosi mereka. Penelitian ini bertujuan untuk menguji ada tidaknya perbedaan yang signifikan pada kemampuan regulasi emosi anak sebelum dan sesudah menggunakan emotion diary. Metode penelitian yang digunakan adalah pendekatan kuantitatif dengan desain penelitian pre-experimental. Penelitian eksperimental ini mengikuti one group pre-test post-test design dengan partisipasi dua puluh dua siswa TK usia 4-5 tahun. Regulasi emosi anak menunjukkan perbedaan yang signifikan antara pretest dan posttest (ρ ≤ 0,05). Hasil penelitian menunjukkan bahwa emotion diary cukup efektif untuk 2 siswa, kurang efektif untuk 12 siswa, dan tidak efektif untuk 8 siswa. Selain itu skor n-gain dalam penelitian ini mencapai 41,99 yang berarti emotion diary mampu meningkatkan regulasi emosi anak dalam kategori sedang. Hal ini mengindikasikan penggunaan emotion diary memiliki banyak manfaat yang dapat meningkatkan kemampuan regulasi emosi pada anak usia 4-5 tahun. Maka penting bagi pelaku pendidikan di bidang anak usia dini untuk mendukung dan membantu anak dalam meningkatkan kemampuan regulasi emosi mereka.
Motivasi Berprestasi Dalam Mengikuti Latihan Di Klub Futsal Sman 11 Bekasi
Authors: Wattimena Ferry , Khaeroni
Published: March 2024

Penelitian ini bertujuan untuk mengetahui motivasi berprestasi dalam mengikuti latihan di klub futsal sman 11 bekasi. Penelitian ini dilakukan dengan menggunakan pendekatan kuantitatif, jenis penelitian deskriptif, dan menggunakan metode survei. Teknik pengumpulan data menggunakan angket atau kuesioner melalui google form. Sampel dalam penelitian ini berjumlah 30 orang. Teknik analisis data dalam penelitian ini menggunakan statistitk deskriptif dan disajikan dalam bentuk presentase. Hasil penelitian menunjukkan motivasi berprestasi dalam mengikuti latihan di klub futsal sman 11 bekasi termasuk dalam kelompok 102-111 dengan rata-rata nilai sebesar 108,67. Secara rinci motivasi berprestasi pada kelompok 122-131 sebanyak 6 orang dengan presentase sebesar 20%. Motivasi berprestasi pada kelompok 112-121 sebanyak 8 orang dengan presentase sebesar 26,7%. Motivasi berprestasi pada kelompok 102-111 sebanyak 9 orang dengan presentase sebesar 30%. Motivasi berprestasi pada kelompok 92-101 sebanyak 2 orang dengan presentase sebesar 6,7%. Motivasi berprestasi pada kelompok 82-91 sebanyak 5 orang dengan presentase sebesar 16,7%.

Kata Kunci: Motivasi, Berprestasi, Futsal

 ABSTRACT

This research aims to find out the motivation to excel in participating in training at the sman 11 bekasi futsal club. This research is conducted using quantitative approaches, descriptive types of research, and using survey methods.Data collection techniques using questionnaires or questionnaires through google form. The sample in this study was 30 people. The data analysis techniques in this study used descriptive statistite and were presented in the form of percentages. The results showed that the motivation to excel in participating in training at the futsal club sman 11 bekasi belonged to the group of 102-111 with an average score of 108.67. In detail, the motivation to achieve in the group of 122-131 as many as 6 people with a percentage of 20%.Motivation to achieve in the group of 112-121 as many as 8 people with a percentage of 26.7%. Motivation to achieve in the group of 102-111 as many as 9 people with a percentage of 30%.Motivation to achieve in the group of 92-101 as many as 2 people with a percentage of 6.7%. Motivation to achieve in the group of 82-91 as many as 5 people with a percentage of 16.7%.

 Keywords: Motivation, Achievement, Futsal
Hubungan Kekuatan Otot Lengan Dan Daya Ledak Otot Tungkai Terhadap Kecepatan Flying-shot Atlet Bola Tangan
Authors: Saputro Yulianto Dwi , Lufthansa Luthfie , Hadi Antonius Prasetyo , Feftyana Fajar
Published: March 2024

Penelitian ini mempunyai tujuan untuk mengukur seberapa signifikan pengaruh kekuatan otot lengan, daya ledak otot tungkai terhadap kecepatan flying-shot pemain bola tangan Kota Malang. Metode penelitian yang digunakan dalam penelitian ini adalah metode korelasional. Sampel dari penelitian ini adalah atlet bola tangan Kota Malang yang berjumlah 9 orang. Hasil penelitian menunjukkan bahwa terdapat hubugan yang signifikan antara kekuatan otot lengan dan daya ledak otot tungkai dengan kecepatan flying-shot. Dapat dibuktikan nilai korelasi (r) antara kekuatan otot lengan (X1) dan daya ledak otot tungkai (X2) dengan kecepatan tembakan melayang (Y) menunjukan rhitung =  0,972> rtabel = 0,666 pada taraf signifikansi 5% sehingga hipotesis nihil (Ho) di tolak dan hipotesis alternatif (Ha) di terima.
WITHDRAWN: Effects of dietary Bacillus pumilus on the growth performance, intestinal health, lipid metabolism, and mTOR signaling pathway of juvenile Coho salmon (Oncorhynchus kisutch)
Authors: Guo Mengjie , Meng Liuqing , Li Fanghui , Liu Yongqiang , Zhang Ziqi , Zhang Qin , Kong Weiguang
Published: March 2024

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Free water surface constructed wetlands: Review of pollutant removal performance and modeling approaches
Authors: Gaballah Mohamed S. , Yousefyani Hooshyar , Karami Mohammadjavad , Lammers Roderick W.
Published: March 2024

Free water surface constructed wetlands (FWSCWs) for the treatment of various wastewater types have evolved significantly over the last few decades. With an increasing need and interest in FWSCWs applications worldwide due to their cost-effectiveness and other benefits, this paper reviews recent literature on FWSCWs' ability to remove different types of pollutants (i.e., nutrients, heavy metals, antibiotics, and pesticides) that may co-exist in wetland inflow, and discusses approaches for simulating hydraulic and pollutant removal processes. A bibliometric analysis of recent literature reveals that China has the highest number of publications, followed by the USA. The collected data show that FWSCWs can remove an average of 61.6%, 67.8%, 54.7%, and 72.85% of inflowing nutrients, heavy metals, antibiotics, and pesticides, respectively. Optimizing each pollutant removal process requires specific design parameters. Removing heavy metal requires the lowest hydraulic retention time (HRT) (average of 4.78 days), removing pesticides requires the lowest water depth (average of 0.34 meters), and nutrient removal requires the largest system size. Vegetation, especially Typha spp. and Phragmites spp., play an important role in FWSCWs' system performance, making significant contributions to the removal process. Various modeling approaches (i.e., black-box and process-based) were comprehensively reviewed, revealing the need for including the internal process mechanisms related to the biological processes along with plants spp., that supported by a further research with field study validations. This work presents a state-of-the-art, systematic, and comparative discussion on the efficiency of FWSCWs in removing different pollutants, main design factors, the vegetation, and well-described models for performance prediction.
Statistical Evaluation of Respondents’ Temperature, Covid-19 Status and Selected Socio-Demographic Variables in Lagos, Nigeria
Authors: Osuolale Kazeem , Adewale Babatunde , Raheem Toyosi , Otekunrin Oluwaseun , Lawal Dayo , Akinsolu Folahanmi , Shobanke Dolapo
Published: March 2024

Global health has been a major cause for concern ever since the coronavirus disease emerged in December 2019. COVID-19 symptoms include an elevated body temperature above the normal, and preventive measures against the causative agent involve social distancing, the use of face masks, and frequent hand washing. This study evaluates respondents’ temperature and COVID status to reduce the risk of SARs-Cov-2 infection. The risk of infection was estimated using a logistic regression model for inferential analysis. Data for this study was collected through a cross-sectional survey that started in March 31, 2020 and ended in April 30, 2020 at the Nigerian Institute of Medical Research in Lagos. The study comprised 2160 participants, of whom 1147 (53.1%) were women and 1013 (46.9%) were men. Among them, 69 (3.2%) tested positive for SARS-CoV-2, with five participants (7.2%) exhibiting elevated body temperature, while 64 (92.8%) participants had normal body temperature. Although gender did not have a significant effect on body temperature (p > 0.05), female participants were 1.5 times more likely to have a normal temperature for the detection of SARS-CoV-2. The temperature of participants was significantly affected by their age (p < 0.05), with odds of having a normal body temperature to detect SARS-CoV-2 being 0.34 times lower for participants aged ≤ 49 years. The mode of transportation used also had a significant effect on the temperature condition of participants (p < 0.05). Participants who walked to the testing center were 2.26 times more likely to have a normal body temperature for the detection of SARS-CoV-2. Furthermore, the COVID-19 status of participants had a significant effect on their temperature (p < 0.05). This study found that participants who tested negative for SARS-CoV-2 were 3.33 times more likely to have a normal body temperature. These results support the notion that asymptomatic transmission is a critical factor in the overall incidence of COVID-19. Furthermore, these findings are consistent with those of other studies conducted during the COVID-19 outbreak in Nigeria. The study's findings on the limitations of temperature as a sole indicator of COVID-19 infection and the potential role of asymptomatic transmission have implications for sustainability in public health. By informing targeted resource allocation, emphasizing holistic approaches to disease management, and promoting effective communication, these findings contribute to sustainable strategies for mitigating the spread of COVID-19 and supporting the overall well-being of communities. The findings of this study can be extended to address broader concerns regarding sustainability and its implications for public health in Nigeria.
Shoulder Shake-up: Unveiling the Unusual Case of Acute Melioidosis
Authors: Khatod Yash , TR Neetha , Kumar Deepak , Gupta Neha , Rajagopal Rengarajan , Tak Vibhor
Published: March 2024

Background: Melioidosis is one of the emerging infections in India, especially in arid northwestern part of the country and often neglected due to lack of awareness among clinicians. The diseases usually present as multifocal or focal abscesses with bacteremia, yet the isolated septic monoarthritic complicated with septic venous thrombosis is a rare presentation.
Case: This case report describes a 48-year-old male business executive with diabetes and alcoholism who developed septic arthritis caused by Burkholderia pseudomallei and no clear history of exposure to the organism. The patient initially experienced fever, chills, fatigue, reduced urine output, and signs of early sepsis. Despite initial improvement with fluid therapy and antibiotics, the patient's fever persisted. Meticulous clinical examination revealed signs of inflammation and movement restriction in the left shoulder which letter on became obvious and the main complaints of patient. Blood cultures confirmed the presence of Burkholderia pseudomallei. Imaging showed septic arthritis, osteomyelitis, lymphadenitis, and venous thrombosis in the left shoulder. Surgical debridement was performed, and the tissue cultures showed the growth of the same pathogen. This led to significant clinical improvement and with prolonged course of antibiotics, complete resolution of symptoms and normal joint function was achieved.
Conclusion: This case report serves to highlight the rare and atypical presentation of Melioidosis and the importance of suspecting this infection in nonendemic regions underscoring the probable impact of climate change. Early diagnosis, effective source control measures and prolonged antibiotic therapy, emerges as pivotal factors contributing to favorable outcomes in such cases.
Experimental and numerical study on the out-of-plane behaviour of auxetic and hybrid auxetic structures
Authors: Bagewadi Santosh S , Bhagchandani Ranjeet Kumar , Manivannan Sugavaneswaran , Sinha Manoj Kumar
Published: March 2024

Auxetic Metamaterials having a negative Poisson’s ratio are gaining attention among researchers due to their excellent energy absorption characteristics.Most of the research on auxetic materials is focused on in-plane behaviour,while out-of-plane loads also influence auxetic materials in practical applications. The current study investigates the out-of-plane behaviour of the auxetic and hybrid auxetic structure. The stress concentration regions of the re-entrant structure are reduced by rounding the corners and varying the strut area uniformly. Recently, a hybrid auxetic structure has been proposed,combining theconventional hexagonal honeycomb and the re-entrant honeycomb to enhance the mechanical properties.All samples are fabricated by Fused filament fabrication method using ABS raw material. Samples were subjected to quasi-static uniaxial compression test in out-of-plane loading direction and a numerical model was developed. The stress-strain plots, energy absorption ability and deformation modes were discussed. The study revealed that the gradient material distribution influenced the improvement in the specific energy absorption of the structures. Further, the specific energy absorption of the hybrid structure (HASr 21 J/g) is improved by 61% than the re-entrant auxetic structure (AS 13 J/g) with nearly the same relative density. This helps in using these structures in potential applications requiring the energy absorption during impact loads.
Synthesis of Metal-Free Benzimidazole-Based Catalysts and its Application in CO2 Cycloaddition
Authors: Lin Li , Yang Huigui , Li Shuangjiang , Liu Yi , Zhi Yunfei , Shan Shaoyun , Xu Juan
Published: March 2024

Ionic polymers functionalized with hydroxyl, carboxyl, and amino groups can enhance the catalytic activity of catalysts. However, the straightforward preparation of bifunctional ionic polymers containing abundant ionic active sites and hydrogen bond donors remains challenging. In this study, a series of porous ionic polymers (BZIs) containing different hydrogen bond donors (-NH2, -OH, -COOH) were prepared through a simple one-pot Friedel-Crafts alkylation using benzimidazole derivatives and benzyl bromide. The structures and properties of BZIs were characterized by various techniques such as Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, solid-state nuclear magnetic resonance and scanning electron microscopy. Among the prepared catalysts (BZI-NH2, BZI-OH, and BZI-COOH), BZI-NH2 exhibited the highest catalytic activity and recyclability, achieving a yield of 97% in the CO2 cycloaddition. The synergistic effect of Br−, hydrogen bond donors (-NH-, -NH2), and N+ in BZI-NH2 was found to contribute to its superior catalytic performance. DFT calculations were employed to study the effect of hydrogen bonds, Br−, and N+ in BZI-NH2 and BZI-OH on the CO2 cycloaddition. Using BZI-NH2 as an example, a mechanism was proposed for the synergistic effect between amino groups and bromide ions in catalyzing the CO2 cycloaddition reaction.
Detection of carbapenemases activity in MDR isolates of Klebsiella pneumoniae by mCIM method and carbapenem resistance genes blaVIM, blaIMP, blaNDM, blaKPC-2 and blaOXA-48
Authors: Mohammadpour Darya , Memar Mohammad Yousef , Kafil Hossein Samadi , Hasani Alka , Rezaee Mohammad Ahangarzadeh , Ghotaslou Anahita , Leylabadlo Hamed Ebrahimzadeh , Nabizadeh Edris , Kadkhoda Hiva , Ghotaslou Reza
Published: March 2024

Klebsiella pneumoniae (K. pneumoniae) is a Gram-negative, opportunistic bacterium that can cause a variety of infections. Antibiotics such as cephalosporins are usually used to treat K. pneumoniae infections. However, resistance of this bacterium to cephalosporins has been reported. For this reason, alternative antibiotics such as carbapenems are used as the last line of treatment for K. pneumoniae. This bacterium becomes resistant to carbapenems by various mechanisms, including enzymatic hydrolysis of carbapenems by producing carbapenemase enzymes (blaVIM, blaIMP, blaNDM, blaKPC−2 and blaOXA−48 genes produce the hydrolysis enzyme). The present study aims to investigate the prevalence rate of MDR K. pneumoniae and the evaluation of resistant isolates to carbapenem was done using phenotypic and genotypic methods. In the present study, 205 K. pneumoniae isolates were collected from patients admitted to the Hospitals of Tabriz University of Medical Sciences from November 2022 to April 2023. Antibiotic susceptibility patterns were determined by disc diffusion method and resistance genes of blaVIM, blaIMP, blaNDM, blaKPC−2 and blaOXA−48 were detected by PCR method. Out of 205 samples collected from K. pneumoniae isolates, 100 samples were multidrug resistant (MDR). Of the 100 MDR K. pneumoniae isolates, 80 samples (%80) were resistant to carbapenems by mCIM method. The frequencies of the blaOXA, blaNDM, blaIMP, blaVIM and blaKPC−2 genes were 52 (65%), 23(28.7%), 12 (15%), 8 (10%) and 5 (6.25%), respectively. Antimicrobial resistance was common and worrying, and rapid and accurate detection of MDR K. pneumoniae isolates can help in the management of patients with K. pneumoniae infections and reduce mortality. Rapid detection of MDR K. pneumoniae can also prevent the spread of resistant isolates.
A Global Correlation between Galaxy Density and Intergalactic HI Gas at z∼4 from Imaging Data
Authors: Uchiyama Hisakazu , Matsuoka Yoshiki , Nagao Tohru , Kashikawa Nobunari , Kurasawa Hina , Toshikawa Jun , Oogi Taira , Umehata Hideki , Kubo Mariko , Toba Yoshiki , Ito Kei
Published: March 2024

Galaxies formed from collapsing clouds of gas and dust, primarily sourced from intergalactic medium (IGM). Thus, achieving a comprehensive understanding the relationship between galaxies and IGM in the early universe (z>3) is crucial for cosmic structure formation, yet remains largely unexplored. We are the first to employ a novel photometric approach based on wide-area data over ~100 square degrees to study the global relationship between IGM HI gas and galaxy density at z~4. We find a significant positive correlation between the galaxy densities and the HI optical depth measured from the colors of background quasars at z~5. In the >4σ galaxy high-density region, the average optical depth is found to be 0.94±0.07, which is 1.2 times larger than the average. The result suggests that IGM HI gas accumulates in the potential well of such high-density regions at this epoch, supported by recent hydrodynamical simulations.
A Case Report of Successful Treatment of a Patient with Anomalous Origin Coronary Artery Suffered from Acute Myocardial Infarction
Authors: Huang Wei , Chen Zhinan , Zhang Huagang , Fu Wenbo
Published: March 2024

A 63-year-old male patient diagnosed as “Acute myocardial infarction" while emergent Coronary angiography showed that the mid-to-distal segment of the circumflex branch was occluded. Unexpectedly, the left coronary artery was originated from the right sinus of Valsalva (ALCA-R). Successful PTCA recover blood flow of the occluded circumflex branch without MACE occurred.
Centromere Positioning Orchestrates Telomere Bouquet Formation and the Initiation of Meiotic Differentiation
Authors: Jiménez-Martín Alberto , Pineda-Santaella Alberto , Martín-García Rebeca , León-Periñán Daniel , Terrizzano Antonia , Daga Rafael , Braun Sigurd , Fernández-Álvarez Alfonso
Published: March 2024

Accurate gametogenesis requires the establishment of the telomere bouquet, an evolutionarily conserved, 3D chromosomal arrangement. In this spatial configuration, telomeres temporarily aggregate at the nuclear envelope during meiotic prophase, which facilitates chromosome pairing and recombination. The mechanisms governing the assembly of the telomere bouquet remain largely unexplored, primarily due to the challenges in visualizing and manipulating the bouquet. Here, using Schizosaccharomyces pombe as a model system to elucidate telomere bouquet function, we reveal that centromeres, traditionally perceived as playing a passive role in the chromosomal reorganization necessary for bouquet assembly, play a key role in the initiation of telomere bouquet formation. We demonstrate that centromeres are capable to induce telomere mobilization, which is sufficient to trigger the first stages of bouquet assembly and the meiotic transcription program in mitotic cells. This discovery highlights the finely tuned control exerted over long-distance heterochromatic regions and underscores a pivotal step in the mechanism of eukaryotic telomere bouquet formation and meiotic transcriptional rewiring.
CCR2+TREM-1+ monocytes promote Natural killer T cell dysfunction contributing towards HBV disease progression
Authors: Wu xiaojuan , Zhao Wenling , Miao Qiang , Shi Shiya , Wei Bin , Luo Limei , Cai Bei
Published: March 2024

Natural killer T (NKT) cells are amongst the most important innate immune cells against Hepatitis B virus (HBV) infection. Moreover, previous studies have shown that HBV infection induced TREM-1 + expression in monocyte and secretion of inflammatory cytokines. Thus, this prompted us to elucidate the role of TREM-1 + monocytes in regulating the function of NKT cells. Ninety patients and 20 healthy participants were enrolled in the study. The percentage and phenotype of iNKT cells and TREM-1 + monocytes were measured in the peripheral blood of healthy controls (HC), patients with chronic HBV infection (CHB), HBV-related liver cirrhosis (LC), and HBV-related acute-on-chronic liver failure (ACLF) via flow cytometry. Moreover, co-culture experiments with NKT cells and TREM-1 overexpressing THP-1 cells were performed to determine the role of TREM-1 in regulation of NKT cell function. We observed that the percentage of NKT cells and CD4-NKT cells gradually decreased, whereas percentage of CCR2 + TREM-1 + monocytes increased with the progression of the disease. In addition, activation of the TREM-1 signaling pathway induced the secretion of inflammatory cytokines leading to pyroptosis of NKT cells and secretion of IL-17 contributing towards disease progression. Therefore, this study suggests that blocking the activation of TREM-1 in monocytes could promote the elimination of HBV by inhibiting pyroptosis of NKT cells and restoring their function. However, further studies are required to validate these results that would help in developing new treatment strategies for patients with HBV infections.
Early Prediction of Acute-on-Chronic Liver Failure Development in patients with diverse chronic liver diseases
Authors: Shen Yuqiang , Xu Wan , Chen Yang , Wen Shengfen , Chen Qijiong , Liu Shanna , Zhu Xinjian , Li Li , Ju Bin
Published: March 2024

Background & aims: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by the acute decompensation of chronic liver disease, leading to organ failures and high short-term mortality. The course of ACLF is dynamic and reversible in a considerable proportion of patients during hospital admission. Early detection and accurate assessment of ACLF are crucial, yet ideal methods remain lacking. Therefore, this study is aimed to develop a new score for predicting the onset of ACLF in patients with diverse chronic liver diseases.
Methods: A total of 6188 patients with diverse chronic liver diseases were included in the study. Clinical and laboratory data were collected, and the occurrence of ACLF within 28 days was recorded. Lasso-cox regression was utilized to establish prediction models for the development of ACLF at 7, 14, and 28 days.
Findings: Among 5221 patients without ACLF, 477 patients progressed to ACLF within 28 days. Seven predictors were found to be significantly associated with the occurrence of ACLF at 7, 14, and 28 days. The new score had the best discrimination with the c-index of 0.958, 0.944, and 0.938 at 7, 14, and 28 days, respectively, outperforming those of four other scores(CLIF-C-ACLF-Ds, MELD, MELD-Na, and CLIF-C-ADs score, all P<0 .001). The new score also showed improvements in predictive accuracy, time-dependent receiver operating characteristics, probability density function evaluation, and calibration curves, making it highly predictive for the onset of ACLF at all time points. The optimal cut-off value (9.6) differentiated high and low-risk patients of ACLF onset. These findings were further validated in a separate group of patients.
Conclusion: A new progressive score, based on seven predictors, has been developed to accurately predict the occurrence of ACLF within 7, 14, and 28 days in patients with diverse chronic liver diseases and might be used to identify high-risk patients, customize follow-up management, and guide escalation of care, prognostication, and transplant evaluation.
Foliar spraying of plant growth regulators can alleviate high-temperature stress in late-sown spring potatoes to improve yield and quality
Authors: Wu Chao , Huang Wensen , Fang Xiaoting , Ma Haiyan , Song Wenwen , Zhang Kaiqin , Ren Zhitong , Shahzad Muhammad Amir , Dolker Dawa , Yang Cuiqin , Zheng Shunlin
Published: March 2024

In practice, late sowing of spring potatoes is commonly adopted to bridge crop rotation and mitigate natural disasters, inadvertently facilitating high-temperature conditions during the latter growth phase, leading to diminished tuber yield and quality. To avert these setbacks, this experiment explored the influence foliar applications of plant growth regulators like Diethyl aminoethyl hexanoate (DTA-6), Uniconazole (S3307), Abscisic acid (S-ABA), and Salicylic acid (SA) on Zhongshu Zao 45 (ZZ45), a late-sowing tolerant variety, and Yunshu 902 (Y902), a sensitive variety. The findings indicated that spraying growth regulators can effectively upgrade the agronomic attributes of late-sown spring potatoes: They curbed the above-ground part of growth, boosted the root-top ratio, promoted dry matter accumulation in the below-ground part, and regulated leaf area index. Physiologically, they increased leaf SPAD value and net photosynthetic rate, reduced MDA and proline content, ultimately increasing yield and improving quality. In the case of the late sowing tolerant variety Zhongshu Zao45 and sensitive variety Yunshu902, S-ABA and S3307 respectively produced the most effective results. A further investigation discovered that S-ABA and S3307 both pitch in endogenous hormone regulation, augmenting antioxidant enzyme activity to bolster plant resilience and alleviate adversity stress from late-sown high temperatures. By selecting appropriate growth regulators for different varieties, it is possible to achieve stable yield and improved quality for late-sown spring potatoes. This study furnishes theoretical insights into the field production of late-sown potatoes.
Identifying the Scope, Relevance and Integration Challenges for Mid-Level Health Providers in India: Perspectives on Advancing Primary Care
Authors: Ugargol Allen Prabhaker , Saikia Bikashita
Published: March 2024

In line with the demographic and epidemiological transition and persisting health disparities, the need for accessible primary health care and access to medical facilities is becoming more relevant than ever today. This demand and deficit is acutely observed in low-and-middle-income countries (LMICs) that harbour a larger proportion of the world’s population and entail a wider disparity in their healthcare access and primary care delivery. One of the modes to overcome this primary care deficit is potentially bridged through community-appropriate staffing, task sharing and augmenting primary care through the introduction of mid-level health providers (MLHPs) now known as the Community Health Officer (CHO). India depicts a very skewed urban-rural distribution of healthcare professionals due to the lack of a supportive rural public health ecosystem coupled with disinterest and lack of motivation among healthcare workers to serve in the rural areas. This has adversely impacted primary healthcare delivery in the rural and tribal pockets of India. It is in this realm that we attempt to provide perspective to the emergence of the Community Health Officer (CHO), the scope they offer and the significance of integrating MLHPs into the public health system in India.