bluuebunny/crossref_metadata_2025 huggingface dataset:
A luta por uma Educação do Campo e não para o campo: protagonismos e desafios dos movimentos sociais
Authors: Siqueira Evangelista Soares , Nogueira Francisco Marcos Mendes
Published: April 2022

O presente ensaio versa sobre o Curso de Licenciatura em Educação do Campo, da Universidade Federal de Roraima, LEDUCARR/UFRR, tendo como pano de fundo o protagonismo dos Movimentos Sociais para a efetivação de uma Educação do Campo e não para o campo no contexto do estado de Roraima. Registra-se que o LEDUCARR tem sua gênese a partir do Edital de convocação nº. 09, de 29 de abril de 2009, do Programa de Apoio a Formação Superior em Licenciatura em Educação do Campo (PROCAMPO), o qual foi uma iniciativa do Ministério da Educação, por intermédio da Secretária de Educação Continuada e Diversidade (SECADI), com apoio da Secretaria de Educação Superior (SESU) e a execução financeira do Fundo Nacional de Desenvolvimento da Educação (FNDE). Dessa forma, após a aprovação do curso foi realizado o primeiro vestibular, em 2010, com o total de 60 vagas, sendo 30 para Ciências Humanas e Sociais (CHS) e 30 para Ciências da Natureza e Matemática (CNM). O diferencial da proposta pedagógica para o LEDUCARR recaiu sob a opção dos princípios da Pedagogia da Alternância através da articulação do Tempo Universidade (TU) com o Tempo Comunidade (TC). Ademais, salienta-se o papel dos Movimentos Sociais para que a Educação do Campo estivesse alicerçada sob o paradigma educação inclusiva dos homens, mulheres e jovens que vivem do e no campo, fugindo dessa forma dos modelos tradicionais que desconhecem o campo como lugar de produção de conhecimento por meio da educação para o campo, ou seja, simplesmente os modelos educacionais urbanos para o campo.
Slavistična prepletanja 1
Authors: Nikolovski Gjoko , Ulčnik Natalija
Published: April 2022

Znanstvena monografija Slavistična prepletanja 1 zajema sedemnajst prispevkov, vezanih na slovenščino, druge slovanske jezike in medslovanske stike. V prvem sklopu so izpostavljeni jezikovnosistemski, zlasti morfološko-sintaktični poudarki sodobnih slavističnih raziskav. Drugi sklop prinaša jezikovnonormativno problematiko in se pri tem osredinja na pravorečje in pravopis v slovanskih jezikih. Tretji sklop je posvečen frazeološkim raziskavam, pri čemer je posebej izpostavljen zlasti medslovanski vidik, izsledki pa posegajo tudi na področje medkulturnosti. Preplet različnih raziskovalnih polj, metodoloških izhodišč in pristopov temelji na izhodiščnem razmisleku o aktualnih slavističnih vprašanjih, njihovih raziskovalnih potencialih ter izzivih slavistike v 21. stoletju.
O izzivih slovenske frazeologije pri pripravi tretje izdaje Slovarja slovenskega knjižnega jezika (eSSKJ)
Authors: Jakop Nataša
Published: April 2022

V prispevku predstavimo tipološko različne izzive, s katerimi se slovenska frazeologija srečuje zlasti pri leksikografskem delu za splošni razlagalni slovar slovenščine (eSSKJ). Osredotočimo se na vsebinske izzive, ki jih pri slovarskem opisu frazeologije sprožajo definicijske lastnosti frazemov in sodobni gradivski viri, ter tehnične izzive, s katerimi se soočamo zaradi specifike slovarskih potreb digitalne dobe. Ob aktualnem frazeološkem gradivu za eSSKJ analiziramo težave, povezane z vključitvijo, obravnavo in prikazom frazemov, njihovih variant in pretvorb.
Raziskovalni potenciali slovanskih in medslovanskih frazeoloških raziskav na primeru nekonvencionalnih replik
Authors: Meterc Matej , Pallay Jozef
Published: April 2022

V raziskovanju paremiološkega žanra nekonvencionalnih replik, ki jim po svetu še ni bilo posvečeno veliko pozornosti, sta se avtorja lahko oprla zlasti na raziskave peščice slovanskih jezikoslovcev. Po izvedbi anket med več kot štiristotimi slovenskimi in slovaškimi govorci ter poizvedovanju pri govorcih drugih jezikov (npr. poljščine, češčine, angleščine in nemščine) ugotavljata, da ima področje frazeoloških replik močan raziskovalni potencial v slovanskem in širšem kontekstu; s frazeološkega in vrste drugih vidikov.
Гневот низ призмата на зоонимната фразеологија во македонскиот и во рускиот јазик
Authors: Mirčevska-Boševa Biljana
Published: April 2022

Фраземите со зоонимна компонента претставуваат значаен дел од вкупниот фразеолошки фонд на секој јазик. Присутноста на животните и непосредниот контакт на човекот со нив, доброто познавање на нивните основните карактеристики, однесувањето и начинот на живот претставуваат одлична основа за разбирање на една од основните и најинтензивните негативни емоции – гневот. Овој труд ќе биде насочен кон анализа на зоонимните фраземи со значење гнев во македонскиот и во рускиот јазик со цел да се идентификува влијанието на зоонимот и метафората во формирањете на значењето на фраземата.
Stereotipi o živalih v srbski in slovenski jezikovni podobi sveta
Authors: Novokmet Slobodan
Published: April 2022

Predmet raziskave so osnovni stereotipi o živalih, ki se oblikujejo v jezikovni podobi sveta slovenskega in srbskega naroda. Stališča in odnosi do živali v srbski ter slovenski jezikovni skupnosti so razvidni tudi na podlagi leksikalno-pomenske in jezikoslovno-kulturološke analize živalskih imen ter njihove metaforične rabe v slovarjih srbskega (RSANU) in slovenskega jezika (SSKJ). Izhajamo iz predpostavke, da pomenske razlage drugotnih pomenov zoonimov v slovarjih obeh jezikov vsebujejo sistemske interpretacije o tem, kako se ti pojmi vrednotijo v posamezni jezikovni in kulturni skupnosti. Raba teh leksemov v kontekstih, zabeleženih v slovarjih, omogoča različne vidike njihove aksiološke obravnave.
Semantička obilježja frazema s komponentom glava/голова u hrvatskom i ukrajinskom jeziku
Authors: Petrovska Lesia , Dugandžić Ana
Published: April 2022

U radu se razmatraju semantička obilježja frazema s komponentom somatizmom glava/голова u hrvatskom i ukrajinskom jeziku. Usporedno proučavanje frazeologije na razini semantičke strukture frazeoloških jedinica omogućuje identificiranje zajedničkih i nacionalno specifičnih obilježja u sadržaju koncepta glava kao fragmenta makrokoncepta „čovjek“ i značajki mehanizama njegove verbalizacije.
Od anjc ko Babogredac. O frazeologiji u govoru Babine Grede
Authors: Babić Sesar Tena , Mance Nina
Published: April 2022

Govor Babine Grede, sela na zapadu Vukovarsko-srijemske županije, pripada govorima posavskoga poddijalekta slavonskoga dijalekta i još uvijek dobro čuva odlike šokačkih govora. Frazeologija babogredskoga govora iznimno je važna jer svojom raznolikošću i bogatstvom svjedoči o kulturi življenja. Odlike su babogredske frazeologije ekspresivnost, inovativnost, kreativnost, originalnost. Posebnost su one frazeološke jedinice koje nisu zabilježene u standardnome hrvatskom jeziku, a bilježe se u govoru Babine Grede. Cilj je članka još jednom uputiti na frazeološko bogatstvo slavonskoga dijalekta, i to na primjeru jednoga mjesnog govora; upravo su frazeološke jedinice svjedokom vremena i kulture u kojem su nastale jer je jezik medij kojim se izriče ono duboko i iskonsko, kultura jednoga naroda u jednome odsječku vremena.
Netožilniški glagoli, tematski vokali in slovenščina
Authors: Mišmaš Petra , Simonović Marko
Published: April 2022

V središče prispevka so postavljeni netožilniški glagoli v slovenščini, tj. neprehodni glagoli, katerih osebek ne nosi udeleženske vloge vršilca (npr. dozoreti). Predstavljeni so v preteklosti predlagani testi za netožilniškost v slovenščini, ki jih nadgradiva s testom netožilniškosti, ki ga za bosanščino/hrvaščino/srbščino predlaga Aljović (2000). Na osnovi tega testa lahko v slovenščini identificiramo 108 netožilniških glagolov. Če te razvrstimo glede na tematske vokale, lahko vidimo, da noben netožilniški glagol ne sodi v največji tematski skupini v slovenščini (i/i in a/a) ter da sodi večina netožilniških glagolov v tematsko skupino e/i, ki je v slovenščini relativno majhna. Obe ugotovitvi predstavljata težavo za standardno razumevanje tematskih vokalov v okviru razpršene morfologije. Predlagava, da tematski vokali v slovenščini niso homogena skupina.
K návaznosti textových jednotek v mluveném narativu
Authors: Bílková Jana , Zeman Jiří
Published: April 2022

Příspěvek je věnován analýze neformálních mluvených textů z hlediska jejich syntaktické stavby. V centru pozornosti stojí struktura tzv. narativu – mluveného komunikátu monologické nebo dialogické povahy, který popisným slohovým postupem zaznamenává průběh jedinečné události. Příspěvek je orientován – v návaznosti na teorii glutinace Jozefa Mistríka – na problematiku textové koheze, tj. na výběr prostředků, které mluvčí využívá k návaznosti jednotlivých výpovědních linií mluveného narativu, a na stupeň jeho syntaktické kondenzace. Příspěvek vychází z analýzy zvukových nahrávek autentických mluvených textů z korpusu neformální mluvené češtiny ORAL v1.
Naglasne značilnosti samostalnikov s končajem -ar v sodobni knjižni slovenščini
Authors: Mirtič Tanja
Published: April 2022

V prispevku so prikazane naglasnomestne značilnosti samostalnikov s končajem -ar v sodobni knjižni slovenščini. Raziskali smo petnajst občnoimenskih samostalnikov, in sicer tako domačih tvorjenk kot tudi prevzetih besed. Tendence naglaševanja v sodobni knjižni slovenščini smo ugotavljali z dvema spletnima anketnima raziskavama. Ob interpretaciji izsledkov raziskav smo skušali pojasniti naglasnomestne tendence obravnavanih samostalnikov.
Vloga zvočnosti v začetnih sT-nizih
Authors: Unuk Drago
Published: April 2022

Prispevek podaja profil začetnih dvočlenskih vzglasnih nezvočniških nizov v slovenskem jeziku glede na usklajenost z razpršenostjo zvočnosti, fonološke razlage nastopanja, izgovarjavo, zgradbo in zaznavnost zloga. V oblikovanju zloga delujeta načelo zvočnosti in načelo raznovrstnosti segmentov. Pomembna sta prag zaznave vzbujanja spremembe in Fibonaccijevo zaporedje, da bi se opazila razlika rasti zvočnosti posameznih konfiguracij: delujeta kot merilo, da se konfiguracija pripornik in zapornik (#sT) uresniči kot regularni nizi v začetnem vzglasju zloga v slovenskem jeziku (jezikih).
İkinci Meşrutiyet İstanbul’una Postmodern Bir Bakış: “Gölgeler ve Hayaller Şehrinde”
Authors: SÜRÜCÜ Özlem
Published: April 2022

Edebi türlerdeki en önemli unsurlardan biri olan mekân, kimi zaman olay ve kurgunun önüne geçerek aktif bir role bürünür. Tanzimat edebiyatında ön plana çıkan mekân unsuru, modern dönemde çeşitli amaçlarla adeta başkahraman konumuna gelmiş, romanın mekânı kimi zaman “mekânın romanı” hâline dönüşmüştür. Pek çok sanatçı ve aydına ilham kaynağı olan İstanbul, hem tarihî arka planı hem de kozmopolit yapısı nedeniyle bu tür mekânların başında gelir. 20. yüzyılın sonlarında edebiyat dünyasına katılan ve postmodernist çizgide eserler veren isimlerden biri olarak Murat Gülsoy, tarihsel türdeki tek romanı “Gölgeler ve Hayaller Şehrinde” adlı eserinde İkinci Meşrutiyet dönemini işlemiştir. Türk fikir dünyasının önemli aydınlarından olan Beşir Fuat’ın oğlu Fuat’ın, arkadaşı Alex’e yazdığı mektuplarla kurgulanmış olan eserde yıllar sonra ülkesine dönen bir Türk’ün gözünden 1908-1909 yılları arasındaki İstanbul ele alınır. Şehrin adım adım dolaşılıp mektuplar aracılığıyla kaydedilmesiyle eser, bir seyahatname hüviyetine büründürülür. Gülsoy “Gölgeler ve Hayaller Şehrinde” adlı eserinde bir şehrin romanını yazmış, şehre adeta bir şahsiyet atfetmiştir. Tarihi olayların, kültürel değerler ve halk anlatılarıyla harmanlandığı bu romanda İstanbul, meşrutiyet hazırlıkları ve sonrasındaki haliyle hem iç, hem de dış mekânlarıyla birlikte canlı bir biçimde resmedilmiştir. Çalışmada postmodernist metinde mekân kavramı tarihsel algı üzerinden değerlendirilecek, Paris’te yetişmiş bir Türk gencinin gözünden İkinci Meşrutiyet döneminin İstanbul’u irdelenecektir.
Humanitarian Evidence and Discourse Summary No.25. K4D Helpdesk Report
Authors: Kelly Luke
Published: April 2022

This is the 24th monthly Humanitarian Evidence Summary (HUMES) to signpost FCDO and other UK government departments to the latest relevant evidence and discourse on humanitarian action to inform and support their response. It is the result of 1 day of work per month and is not intended to be a comprehensive summary of available evidence on humanitarian action but aims to make original documents easily accessible to decision-makers that, if relevant to them, they could refer to before making decisions.
Türkiye de Bölgesel İşsizlik ve Suç Türleri İlişkisi: Panel Veri Yaklaşımı
Authors: Cinar Mehmet , Tas Canan
Published: April 2022

Bu çalışmada, Türkiye’nin 26 bölgesi için 2009-2019 dönemi verileri kullanılarak işsizlik ile suç türleri arasındaki ilişki panel veri yaklaşımıyla incelenmiştir. Ayrıca suç modeli mala karşı ve cana karşı olmak üzere iki kategori halinde de analiz edilmiştir. Analiz sonuçlarından elde edilen bulgulara göre, işsizlik ile suç arasındaki ilişkinin beklentiler yönünde pozitif olduğu sonucuna ulaşılmıştır. Ayrı ayrı suç türleri açısından değerlendirildiğinde ise işsiz kalan bireylerin en fazla yöneldikleri suç türünün hırsızlık, en az yöneldikleri suç türünün ise hakaret suçu olduğu belirlenmiştir. Mala ve cana karşı suç türleri sonuçlarına bakıldığında da işsizlikteki bin kişilik artışın mala karşı suçları cana karşı suçlara göre yaklaşık üç kat artırdığı tespit edilmiştir. Ayrıca, işsizlik ve boşanmalardaki artışın suç eğilimini artırdığı; gelir ve eğitimdeki artışın ise suç eğilimini azalttığı tespit edilmiştir. İlaveten işsizlik, boşanma, gelir ve eğitim değişkenlerinin tamamının mala karşı suçlar üzerinde cana karşı suçlara göre daha fazla etkili olduğu görülmüştür. Her ne kadar çoklu regresyon modelinde birçok bağımsız değişken kullanılmış olsa da suç üzerinde en etkili olan değişkenin işsizlik olduğu tespit edilmiştir.
The 2020 Chadema special seats dispute in Tanzania.Does the National Electoral Commission Comply with the Law?
Authors: Lihiru Victoria
Published: April 2022

This article focuses on the CHADEMA dispute regarding the selection of its 19 women to special parliamentary seats after the completion of the 2020 general elections in Tanzania. It argues that the dispute is caused by the failure of the National Electoral Commission (NEC) to provide political parties with a uniform and transparent modality for the selection of women to special seats against the requirement of Article 81 of the 1977 Constitution. The NEC’s failure has led to modalities of implementing women’s special seats that are incompatible with the international standards governing ‘Temporary Special Measures’ (TSM). This has led to conflict, the marginalisation and discrimination of women in special seats, ridicule of the special seats system, and a slow transition of women from special to constituency seats. The article provides suggestions on how the special seats system could be reviewed and repositioned to achieve its intended objectives.
Editorial: Languages in Early Childhood Education
Authors: Slaughter Yvette , Keary Anne , Gillian Pennington , Bonar Gary
Published: April 2022

In the context of ever-changing global movement of peoples in and between countries, linguistic diversity, and diversity in modes of communication and expression have become increasingly vibrant and visible (D’warte & Slaughter, 2021). These changes have also been reflected in research scholarship into languages acquisition where monolingual-centric assumptions have been disrupted by heteroglossic perspectives that view the linguistic repertoire of any individual, including the very young child, as complex – shaped by the “linguistic, cognitive, social and emotional” characteristics of the individual (Seltzer & García, 2020, p. 2). In orienting this to the classroom, Cummins & Early (2011) argue that the relationship between language and identity cannot be untwined but that indeed, a critical precondition for learning involves recognising and engaging with the cultural and linguistic knowledges and learning experiences of students.
Mothers as First Teachers: Exploring the Features of Motherchild Interactions That Support Young Aboriginal Children’s Multilingual Learning at Playgroup
Authors: Scull Janet , Page Jane , Lee Wan Yi , Murray Lisa , Gapany Dorothy , Stewart Samantha , Murukun Marilyn , Scannell Nuala , Lawrence Rona , Dhurrkay Jonica , Hayes Felicity , Burarrwanga Verity , Chynoweth Leah , Callahan Michelle , Goveas Jessica Noella , Cock Megan L. , Mentha Susan , Eadie Patricia , Sparling Joseph
Published: April 2022

For many Indigenous children living in remote communities, the prerequisites to achieving strong language and learning outcomes include the maintenance of their first languages and progress in learning English as an additional language. This paper reports on data from a Linkage study conducted with families at two Families as First Teachers (FaFT) playgroups in two remote Northern Territory communities. The data highlight the ways parents and carers encouraged very young children to engage in home languages as a foundation on which to develop skills in English during play and book reading activities. Transcripts of mother-child book reading and play sessions and reflections of FaFT Family Liaison Officers are examined to explore the language interactions and the strategies used by mothers to support children’s multilingual learning. The data highlight the importance of early childhood teaching and learning that honours children’s linguistic and cultural resources and prioritises families’ aspirations for children’s multilingual language learning.
Early Language Learning and Teacher Education. International Research and Practice.
Authors: Uptin Jonnell
Published: April 2022

EARLY LANGUAGE LEARNING AND TEACHER EDUCATION. INTERNATIONAL RESEARCH AND PRACTICE.

Zein, S. and Garton, S.Bristol and Blue Ridge Summit, Multilingual Matters, 2019
Notes for contributors & Advertising rates
Authors: TESOL in Context Journal Coordinator
Published: April 2022

Notes for contributors

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Radiomics-based distinction of small (≤2cm) HCC and precancerous lesion based on precontrast MRI
Authors: Gao XiaoNing , Luo JiaWen , Guo Kun , Xiang Yue , Liu Hao , Ding Jia
Published: April 2022

Background: The pre-HCC describe the precancerous condition of HCC, which include regenerative nodule (RN), low-grade dysplastic nodule (LGDN) and high-grade dysplastic nodule (HGDN) [1].Purpose: To assess the feasibility of radiomics based on precontrast MRI for the distinguish of small hepatocellular carcinoma (S-HCC) (≤2cm) and pre-hepatocellular carcinoma (pre-HCC). Method: We retrospectively analyzed 146 nodules with pathological confirmed from 78 patients. Each nodule was segment on precontrast MRI sequence (T1WI and fat-suppression T2WI (FS-T2WI) ), retrospectively. 1223 radiomics features were extracted and the optimal features from T1WI, FS-T2WI and T1WI+FS-T2WI were selected by the least absolute shrinkage and selection operator (LASSO). We used the logistic regression classifier to establish the radiomics model. Result: We applied logistic regression classifier to identify S-HCC and pre-HCC on the basis of valuable radiomics features extracted from T1WI, FS-T2WI, T1WI+FS-T2WI, respectively. The AUC, sensitivity and specificity of the training group and test group based on T1WI were 0.879 (95% CI 0.797 -0.962), 78.9% and 83.1% and 0.796 (95% CI 0.619-0.973), 66.7% and 83.3%, respectively. The AUC, sensitivity and specificity of the training group and test group based on FS-T2WI were 0.911 (95% CI 0.839-0.983), 94.7% , 83.1% and 0.907 (95% CI 0.779-1), 83.3%, 88.9%, respectively. The AUC, sensitivity and specificity of the training group and test group based on T1WI+FS-T2WI were 0.918 (95% CI 0.844-0.991), 84.2% , 87.3% and 0.870 (95% CI 0.728-1), 84.2%, 87.3%, respectively. Conclusion: This study suggested that radiomics model may serve as an adjunct and noninvasive tool to classify S-HCC and pre-HCC based on precontrast MRI.
Artificial Intelligence with CBC based Morphometric Parameters aimed toward effective diagnostic practices for Dysplasia associated Hematological Malignancies
Authors: Haider Zeeshan , Ujjan Ikram Uddin , Khan Najeed Ahmed , Farooq Muhammad Umer , Nazir Waseemullah , Urrechaga Eloisa , Khanani Muhammad Rafiq
Published: April 2022

Background: The diagnosis and classification of dysplasia associated hematological neoplasms is dominated by morphology. Current round of study made use of potential ‘fingerprints’ among routinely generated diagnostic data particularly morphological and immature fraction-related (morphometric) parameters produced during routine complete blood count (CBC) testing in hemat-oncology department through artificial intelligence predictive modeling.Methods: Along conventional statistics, neural network models were trained on anonymized demographical, clinical and diagnostic data of total 1624 individuals with common hematological neoplasms. In addition, validation conducted on independent dataset. The frameworks were trained to differentiate hematological malignancies cases with various sub-entities of Dysplasia against Non-dysplastic group as a control cohort.Results: Our predictive model attained greater precisions; percent incorrect prediction were remained 10.3 and 4.6 for training and testing phases, respectively along with a 95.4% negative predictive value (NPV). Moreover, higher accuracy (93.1%) was obtained during prospective validation in challenge of independent dataset. Model’s performance related metrics: the gain and lift chart, predictive-pseudo probability chart, and receiver operative curve (ROC) curve were noted as persuasive. Considering the sensitivity and specificity, area under the curve (AUC) values were also noted quite convincing; 0.954 for Non-dysplasia group while 0.994 for acute myeloid leukemia with dysplasia (AML-Dys) followed by 0.992, 0.988, 0.986, 0.984, 0.973, and 0.962 for chronic myelo-monocytic leukemia (CMML), refractory anemia with excess blast-I (RAEB-I), refractory anemia with excess blast-II (RAEB-II), refractory anemia with multi-lineage dysplasia (RCMD), Hypoplastic myelodysplastic syndrome (H-MDS), and refractory anemia with uni-lineage dysplasia (RCUD) respectively.Conclusion: The negative predictive efficiency of our framework advocates its utility as a screening tool for the rapid expulsion of Dysplasia associated hematological neoplasms in hemat-oncology sections, aiding prompt care decisions.
CLPX regulates mitochondrial fatty acid β-oxidation by modulating protein complex formation in liver cells
Authors: Furuyama Kazumichi , Suzuki Ko , Kubota Yoshiko , Kaneko Kiriko , Kamata Costantine
Published: April 2022

Mitochondrial fatty acid oxidation (β-oxidation) is an essential metabolic process for energy production in eukaryotic cells, but the regulatory mechanisms of this pathway are largely unknown. In the present study, we found that several enzymes involved in β-oxidation are associated with CLPX, the AAA + unfoldase that is a component of the mitochondrial matrix protease ClpXP. Deletion of the CLPX gene increased β-oxidation activity in human hepatic cells but did not change the protein levels of enzymes involved in β-oxidation. Moreover, glucagon treatment resulted in decreased CLPX levels and increased β-oxidation activity in these cells, while the expression levels of enzymes involved in β-oxidation were not altered. Coimmunoprecipitation experiments revealed that glucagon treatment induced the dissociation of several β-oxidation-related enzymes from CLPX, suggesting that CLPX regulates β-oxidation by modulating the protein complex formation of enzymes catalyzing β-oxidation.
Femoral head osteonecrosis post-COVID-19 infection, a prophecy coming true. A report of seven hips.
Authors: Mahran Mohamed A. , Hassan Ahmed Abdelazim A. , Moustafa Mohamed MA , Bakr Hatem , Abdelaal Ahmed M. , Khalifa Ahmed A.
Published: April 2022

Background: COVID-19 is relatively a new condition, the long-term effects of which have not been thoroughly studied yet. Musculoskeletal complications following COVID-19 infection or because of its medications used had been reported in the literature. Here, we report on seven hips in four patients who presented with osteonecrosis of the femoral head (ONFH) after having COVID-19 infection and their treatment regimen included glucocorticoid. Cases presentation: Four patients presented to us complaining of hip pain (bilateral in three patients and unilateral in one), all reported being diagnosed as having COVID-19 infection, and their line of management included corticosteroids intake for various durations. The diagnosis was confirmed by plain hip radiographs and magnetic resonance imaging. The disease was in the early stages in all patients without femoral head collapse. Thus, all hips were treated by core decompression.Conclusion: ONFH is a real concern in patients who had COVID-19 infection, especially when corticosteroids were administered as part of their management. A follow-up and screening strategy should be established for patients who had COVID-19 infection to detect early development of hip osteonecrosis.
Perceptions and attitudes of black men in a rural district of South Africa towards depression and its treatment
Authors: Masemola Hlabje Carel , Moodley Saiendhra Vasudevan , Shirinde Joyce
Published: April 2022

Background: Depression is a major contributor to the overall global burden of disease impacting social life, family life, and occupational functioning if left untreated. Despite its high prevalence and morbidity, the evidence suggests men are hesitant to seek help with a large percentage remaining undiagnosed. This study aimed to determine the attitudes and perceptions related to depression and its treatment among black men in a rural district of South Africa. Methods: The design used was exploratory descriptive qualitative design. Participants were selected by purposive sampling technique. Individual semi-structured interviews were conducted which were audio-recorded and transcribed verbatim. The data were subsequently analysed thematically to develop themes and subthemes.Results: Participants described depression as a psychological problem associated with lack of sleep, loneliness, feeling unwanted, increased stress, deep sadness, weight loss, forgetfulness, crying over small things, and lack of concentration. Collectively, the interviews with participants exposed a limited understanding of the causes of depression. A large proportion (n=13) of participants reported not having knowledge of available services in their area for people who seek treatment for depression. Barriers to help-seeking behaviours were fear of social stigma, fear of expressing their feelings, gender norms and stereotypes, and lack of trust in others.Conclusions: Interventions such as support groups and mental health awareness programs to counteract personal perceptions may help to improve and expand the effectiveness of depression treatment. The results highlight the future need to raise awareness of depression symptoms and expand outreach health programs.
Finding the best approach for the transportation sector to synergistically reduce CO2 and air pollutants emissions
Authors: Wang Yuan , Ping Liying , Lee Lien-Chieh , Zhang Hongyu , Peng Binbin , Pan Zhou , Yang Chenbo
Published: April 2022

The transportation sector has a significant impact on the synergistic reduction of CO2 and pollutants. Using a structural path decomposition, we reveals the direct and embodied CO2 and NOx emissions from the transportation sector triggered by key supply chain pathways. Meanwhile, the emission abatement potential and economic costs of 33 vehicle specific abatement technology options are analyzed based on the input-output analysis for life cycle assessment. The results show that most of the vehicle technology options can reduce CO2 and NOx emissions while saving economic costs. Among these technologies, both the pure electric technology for passenger cars and the parallel hybrid technology for heavy-duty trucks have high abatement potential. Compared to costly pure electrification technologies for passenger cars, parallel hybrid technologies for heavy-duty trucks offer the highest economic benefits as well as a better driving mileage. Therefore, hybrid heavy-duty trucks will be a more comprehensive solution in the near future.
Cerebrospinal fluid circulating tumor DNA depicts profiling of brain metastasis in NSCLC
Authors: Zhang Longbo , Wu Jun , Liu Zhiqiang , Huang Tianxiang , Wang Ying , Song Mengmeng , Song Tao , Zhang Xiaobing , Li Xi , Long Gretchen
Published: April 2022

Brain metastasis (BM) genetically diverges from the primary tumor in non-small-cell lung cancer (NSCLC). Hence, accurately capturing clinically relevant alterations is pivotal for the delivery of targeted therapies. Circulating tumor DNA (ctDNA) sequencing has emerged as a promising liquid biopsy in the biomarker-based clinical management of recurrent and extracranial metastatic NSCLC. However, absence of simultaneous sequencing data from brain metastatic sites prevents the definitive evaluation of the efficacy of ctDNA representing genetic profiles in BM. Here, we performed parallel genomic comparisons between matched BM and primary tumor DNA, plasma ctDNA, and cerebrospinal fluid (CSF) ctDNA. The results indicated that CSF ctDNA had a greater ability than plasma ctDNA in comprehensively representing the mutational landscape of BM, with CSF ctDNA detecting all BM mutations in 83.33% of patients while plasma ctDNA was only 27.78%. Mutant allele frequency (MAF) in CSF ctDNA was highly correlated with the tumor size of BM (r = 0.95), and the mean MAF in CSF ctDNA was more abundant than that in plasma ctDNA (38.05% vs. 4.57%). MAF and tumor mutational burden (TMB) in CSF ctDNA were strongly associated with those in BM (r = 0.96 and 0.97, respectively). Of note, CSF ctDNA had significantly higher concordance with BM than plasma ctDNA (99.33% vs. 67.44%), facilitating the identification of clinically relevant mutations. Moreover, we found that plasma ctDNA has stronger profiling performance with a concordance of 93.01% in multiple brain metastases, equivalent to CSF ctDNA. Collectively, our study indicates that CSF ctDNA is superior to plasma ctDNA in accurately represent the profiling of single BM, plasma ctDNA could be an alternative liquid biopsy material to be applied in multiple brain metastatic NSCLC.
A density functional theory study of adsorption and dissociation of H2 molecule on small PdnAgm (n + m ≤ 4) metal clusters
Authors: Al-Odail Faisal , Mazher Javed
Published: April 2022

The adsorption and dissociation of hydrogen molecule on small PdnAgm (n + m ≤ 4) clusters is studied employing density functional theory (DFT) calculations. The lowest energy structures of the PdnAgm clusters are initially presented. Based on the obtained structures, various geometries of H2 adorption and dissociation with these clusters are examined. The cluster size and composition of the PdnAgm clusters are found to control the nature of the adsorption process. The results suggest that molecular adsorption is more favourable on the Pd atom and mixed clusters, while hydrogen dissociation is more favourable on the Pdn (n = 2–4) clusters. The Pd dimer and trimer are found to be the most reactive clusters for hydrogen adsorption, while single Ag atom is the least reactive one. The natural bond orbital (NBO) population analysis indicates that hydrogen atoms tend to draw electrons from the metal clusters in the dissociative form and donate electrons to the metal clusters in the molecular adsorption form. The density of states (DOS) of the PdnAgm trimers are also presented and discussed.
Assessment of social vulnerability to groundwater pollution using K-means cluster analysis.
Authors: Uzcategui-Salazar Marisela , Lillo Javier
Published: April 2022

It is possible to assess the harm that society suffers from an anthropogenic event based on the impact of groundwater pollution on society. Indexing methodologies are commonly applied to assess the social vulnerability of aquifers. However, they assign weighting and rating values for the different factors involved, make them very subjective. This research proposes to assess the social vulnerability to groundwater pollution by considering three factors: the uses of groundwater resources, the exposed population, and the socio-economic losses. In order to eliminate the subjectivity of indexing methodologies, a K-means cluster analysis was used to assess the social vulnerability. Using this method, a social vulnerability map can be produced with greater objectivity. The proposed methodology was applied to an aquifer located in central Spain, an area with significant agricultural development. Low population density and unproductive zones result in low social vulnerability in most of the area. Nevertheless, high social vulnerability is observed in the southern regions due to agricultural development which leads to higher socio-economic variables and demand for groundwater resources for agricultural activities. Similarly, high social vulnerability is observed in the northeast, mainly influenced by groundwater use and exposed population. These results show that social vulnerability in most of the study area is not very significant for assessing the risk of groundwater contamination, because the damage to the social, environmental or economic sector is low. However, in the south and northeast in the study area, pesticides and fertilisers should be used with caution, as they significantly increase the risk of groundwater contamination and thus the impact on society. The K-means clustering method proved to be an objective and effective option for assessing social vulnerability to groundwater pollution in aquifers.
Acute Traumatic Pathologies (Especially Rib Fractures) Based on Age and Gender in Patients with Blunt Thoracic Trauma: a CT Study
Authors: Torun Ebru , Yuksel Yavuz
Published: April 2022

Aim:To analyze the differences in acute traumatic pathologies (especially rib fractures) based on age and gender in patients with blunt thoracic trauma.Material and Method:411 patients aged 18-years or more with acute thoracic traumatic pathology on CT-examination were included in the study. The patients were classified into 3 age groups: Group-1:18-44 years, Group-2:45-69 years, and Group-3:70 years or more. Rib fractures were classified into 3 groups based on their level on the coronal plane(upper(1st-4th ribs), medium(5th-8th ribs) and lower(9th-12th ribs)) and axial plane(anterior, lateral and posterior).Results:Rib fractures were found to be more common in men(69%) to women(53%)(p=0.002). The incidence of fractures was seen to increase with age(p=0.001; r=615).Rib fractures were most commonly found in the middle ribs(5th-8th ribs)in all-age-groups.The incidence of fractures in the upper ribs was significantly lower in the advanced age than the other age groups(p=0.002).Fractures were least commonly found in the anterior part of the rib in all-age-groups.Rib fractures were observed at a higher rate in the lateral part in young adults unlike the other age groups(p=0.001).A significant difference was found between the age groups in favor of young adults(group 1) in terms of the presence of parenchymal contusion without rib fracture(p=0.014).Conclusion;Rib fractures are more common in men than women.Fractures possibility of in the upper rib structures is lower in the advanced age group.Fractures in the lateral part of the ribs are more common in young people.One should be aware of the possibility of parenchymal contusion without a rib fracture in the young age group.
ddRADseq -mediated detection of genetic variants in sugarcane
Authors: Molina Catalina , Vera Pablo Alfredo , Aguirre Natalia Cristina , Filippi Carla Valeria , Puebla Andrea Fabiana , Poltri Susana Noemí Marcucci , Paniego Norma Beatríz , Acevedo Alberto
Published: April 2022

Sugarcane (Saccharum sp.), a world-wide known feedstock for producing sugar, bioethanol, and energy, has an extremely complex genome due to its highly polyploid and aneuploid nature. A double digestion restriction site-associated DNA sequencing protocol (ddRADseq) was tested in four commercial sugarcane hybrids and one high-fibre biotype for the detection and potential application of single nucleotide polymorphisms (SNPs) in genetic breeding. This genotyping approach compared two Illumina sequencing platforms and different filtering schemes, with and without a reference genome. A greater number of reads were obtained with Illumina platform Novaseq6000 than with Nextseq500, being this consistent with a greater number of SNPs determined with high accuracy. Additionally, more SNPs were found using a denovo pipeline compared to de refmap pipeline of the Stacks software. Longer read size, paired-end reads and 4M reads per individual represent the most efficient combination in recovering SNPs. The optimal combination of filter parameters varied depending on the different matrices created based on the different platforms. In both matrices, the highest number of SNPs localized in the longest chromosome 1, whereas the fewest landed in the shortest chromosomes 5 and 8. Multivariate comparisons of the SNPs matrices showed closer relationships among commercial hybrids than with the high-fibre biotype. Functional analysis of the obtained SNPs, performed with the Variant Effect Predictor, demonstrated the appearance of variants throughout the sugarcane genome. The pipeline applied in this study can be exploited to identify useful molecular markers that can be used in sugarcane breeding programs to reduce selection cycles.
Comparative evaluation, effectiveness and validity of 2 systems in the surgical planning of dentofacial deformities
Authors: Piombino Pasquale , Abbate Vincenzo , Sani Lorenzo , Troise Stefania , Committeri Umberto , Carraturo Emanuele , Maglitto Fabio , De Riu Giacomo , Vaira Luigi Angelo , Califano Luigi
Published: April 2022

Purpose
Over 70% of patients suffering from dentofacial deformity mention esthetics as the biggest issue pushing them to look for orthodontic and orthognathic treatment. At present, several software for computer-aided surgery have been released on the market, this surgical planning software allow surgeons to manipulate digital representations of hard and soft tissue profile tracings and subsequently morph the pretreatment image to produce a treatment simulation. The aims of this study was to investigate and find the difference between 2 of the most used digital software in the pre-surgical planning for patients affected by dentofacial deformities.
Methods
That was granted by using the following parameters: usability, validity, timing, accessibility, efficacy and predictability of the pre-surgical planning and the software costs. Ethical approval, to access and use the data, was obtained from the Federico II Research Ethic Committee (371/2019, approved in 21/02/2020).
Results
Analyzing the results obtained from our study, it is correct to define both software tools useful and valid in the digital surgical planning for treatment of patients with dentofacial deformities. Each software has negligible differences in performance that do not in any way affect the success of the surgical planning.
Conclusion
Despite a slight difference regarding the costs for the purchase of the license, which see the IPS software slightly more expensive than the Dolphin software, the IPS software represents not only a valid alternative to the most popular and tested Dolphin Imaging software, but it is even inclined to evaluate it better in terms of accuracy, effectiveness, and reliability.
The First Record in Turkey of Pachycrepoideus vindemmiae as a parasitoid of Ceratitis capitata: Molecular identification
Authors: Tiring Gülsevim , Tusun Adnan , Kalkan Çağlar , Satar Serdar
Published: April 2022

Ceratitis capitata Wied. (Diptera: Tephritidae) is a polyphagous species and a serious pest worldwide. In the present study, surveys for associated C. capitata parasitoids were conducted in the Adana province of Turkey. Our finding represents the first record in Turkey of Pachycrepoideus vindemmiae Rondani (Hymenoptera: Pteromalidae) as a parasitoid of C. capitata.
Performance Analysis of Full-Duplex Densely Distributed MIMO with Wireless Backhaul
Authors: Wan Ziqian , Pan Qijun , Li Jiamin , Zhu Pengcheng , Wang Dongming , You Xiaohu
Published: April 2022

In this paper, the spectral efficiency of a full-duplex densely distributed multi-input multi-output (MIMO) system with wireless backhaul is considered. In-band full-duplex (IBFD) backhauling, in which the backhual and access transmission take place on the same spectrum, is exploited for wireless backhauling to enable efficient spectrum reuse. However, the severe cross-tier interference and cross link interference (CLI) reduce the gains of IBFD backhauling. To evaluate the achievable spectral efficiency with imperfect channel state information (CSI), we propose a two-phase channel estimation scheme to estimate CSI for two wireless links, and the scheme estimates effective interference CSI between APs based on beamforming training to perfom interference cancellation at access points (APs). Given the estimated CSI, the closed-form expressions of the uplink and downlink achievable rates respectively with maximum ratio transmission (MRT) beamforming and maximum ratio combining (MRC) receivers are derived with Gamma approximation. Numerical results verify the accuracy of the derived closed-form expressions and the effectiveness of two-phase channel estimation scheme for interference cancellation. Besides, compared with half-duplex densely distributed MIMO systems, full-duplex systems with interference cancellation provide better performance.
A Novel Method for Prediction and Classification of Breast Cancer Using Deep Learning Techniques
Authors: N Krishna Veni N , V Preetha , K Meena , T Kamaleshwar , R Mayuri A V , Shareefunnisa Syed
Published: April 2022

Breast disease is the prevalent malignant growth in female all over the world and it is expanding in non-industrial nations, where most cases are analyzed late. Mammography remains the best symptomatic advance from a treatment standpoint, despite widespread use and investigation of these images. The main objective of this paper is to predict and classify the breast cancer using deep learning techniques. The extensive experiments are conducted on Wisconsin Demonstrative Bosom malignant growth (WDBC) dataset extricated from digitized pictures of Random MRI. Deep learning techniques such as Deep Neural Network (DNN), Recurrent Neural Network (RNN) and Local Linear Radial Basis Function Neural Network (LLRBFNN) are used for experimental investigation. The performance of the proposed approach is analyzed through accuracy, Jaccard index, Precision, Recall and F1 score.
Mapping the incidence of drug-induced liver injury worldwide: a systematic review and meta-analysis
Authors: Li Min , Wang Yu , Lv Tingting , Liu Jimin , Kong Yuanyuan , Jia Jidong , Zhao Xinyan
Published: April 2022

Background: Drug-induced liver injury (DILI), an increasing etiology of liver dysfunction in hepatology, its incidence has been variably reported worldwide. To better understand the disease burden hence make appropriate preventive and treatment strategies, we conducted this meta-analysis from global perspective.Methods: PubMed, EMBASE, Web of Science and Cochrane Library were searched for studies on the incidence of DILI published from inception to Aug 1, 2021. According to the predefined criteria, only population-based studies were included. Incidence was calculated as cases per 100,000 person-years with its confidence interval (CI) using random effects model. Results: A total of 31 studies were included. The overall incidence of DILI was 4.94 (95%CI: 4.05-5.83) per 100,000 person-years. Time-based cumulative meta-analysis suggested that the incidence of DILI had increased over time since 2010. It varied by regions: Asia had the highest incidence, at 17.82 (95%CI: 6.26-29.38) per 100,000 person-years, while America had the lowest, at 1.72 (95%CI: 0.48-2.95) per 100,000 person-years. All studies had a consistent result of higher incidence of DILI in elders; but comparable incidence between male and female (3.42 vs 4.64 per 100,000 person-years). As for the specific implicated drug(s), the incidence of statins induced liver injury was 11.30 (95%CI: 6.48-19.69) per 100,000 person-years, while the incidence among patients using antifungal drugs, antidepressants, paracetamol, antidiabetic, anti-tuberculosis, nonsteroidal anti-inflammatory drugs, anti-thyroid drugs and iron chelator ranged from 0.16 to 180.97 per 100,000 person-years. Conclusions: The incidence of DILI has been increasing since 2010 worldwide, with the highest incidence in Asia. Understanding the epidemiological characteristics of DILI aids in making specific strategies to deal with the emerging health problems.
Added value of 18F-FDOPA PET to the management of high-grade glioma patients after their initial treatment: a prospective multicentre study
Authors: Darcourt Jacques , Bourg Véronique , Gal Jocelyn , Schiappa Renaud , Blonski Marie , Almairac Fabien , Mondot Lydiane , Jeune Florence Le , Collombier Laurent , Kas Aurélie , Taillandier Luc , Verger Antoine
Published: April 2022

Background. Diagnostic value of 18F-fluoro-L-dihydrophenylalanine (18F-FDOPA) PET in patients with suspected recurrent gliomas is recognised. We conducted a multicentre prospective study to assess its added value in the practical management of patients suspected of recurrence of high-grade gliomas (HGG).Methods. Patients with a proven HGG (WHO grade III and IV) were referred to the multidisciplinary neuro-oncology board (MNOB) during their follow-up after initial standard of care treatment and when MRI findings were not fully conclusive. Each case was discussed in 2 steps. For step 1, a diagnosis and a management proposal was made only based on the clinical and the MRI data. For step 2, the same process was repeated considering the 18F-FDOPA PET results. A level of confidence of the decisions was assigned to each step. Changes in diagnosis and management induced by 18F-FDOPA PET information were measured. When unchanged, the difference in the confidence of the decisions was assessed. The diagnostic performances of each step was measured.Results. 107 patients underwent a total of 138 MNOB assessments. The proposed diagnosis changed between step 1 and step 2 in 37 cases (26.8%) and the proposed management changed in 31 cases (22.5%). When the management did not change, the confidence in the MNOB final decision was increased in 87 cases (81.3 %). Step 1 had a sensitivity, specificity and accuracy of 83%, 58% and 66% and step 2, 86%, 64% and 71% respectively.Conclusion. In case of equivocal MR findings, 18F-FDOPA PET adds significant information for the follow-up of HGG patients in clinical practice.
Effect Of Aerobic Exercises Along With Music Therapy On The Fatigue And Quality Of Life In Female With Thyroidectomy Following Thyroid Cancer: A Research Protocol
Authors: Saklecha Akshaya V. , Patil Shubhangi
Published: April 2022

Background-
Thyroid cancer, which manifests as a solid tumour cancer of the thyroid gland, is the most common endocrine cancer in women and the sixth most common cancer overall. Its prevalence has been rapidly rising in India, particularly among the younger population, with a rise in fatigue caused by cancer and poor quality of life in females following thyroidectomy.
Aim-
This experimental study protocol has been designed to evaluate the effect of Aerobic exercises along with Music Therapy on the fatigue and quality of life in female with thyroidectomy following thyroid cancer.
Methods-
The study's participants (n = 30) will be females who underwent thyroidectomy and meet the inclusion criteria. The participants will be enrolled in the study, ensuring that the six-week session is effectively completed. Aerobic exercises are combined with music therapy as the intervention. Fatigue and quality of life will be evaluated pre and post-treatment by using the Fatigue assessment scale and Rand SF-36 Questionnaire.
Conclusion-
This is a unique study, since a similar study has not yet been carried out. This study evaluates the effect of Aerobic exercises combined with Music Therapy by determining the fatigue caused by cancer and quality of life in females with post thyroidectomy following thyroid cancer.