bluuebunny/crossref_metadata_2025 huggingface dataset:
Injection-molded lightweight and high electrical conductivity composites with microcellular structure and hybrid fillers
Authors: Tian Sheng , Dong Binbin , Guo Yahao , Zhao Can , Zhang Mengxia , Xiao Mengjun
Published: September 2019

Polypropylene/carbon black (PP/CB) and PP/CB/multiwalled carbon nanotube (PP/CB/MWCNT) composites were fabricated by solid and foam injection molding, with the goal of enhancing the electrical conductivity of the composites while decreasing the cost of the final product. The foaming behavior and through-plane (T-P) electrical conductivity of the composites were characterized and analyzed. Cell growth increased the interconnection of the conductive fillers, changed the filler orientation, and enhanced the T-P electrical conductivity of the composites. Under appropriate processing conditions (200°C melt temperature, 70 cm3/s injection flow rate, and 5% void fraction), the T-P electrical conductivity of the foam PP/CB composites was 5 orders of magnitude higher than that of the solid composites (from 5.877 × 10−12 S/m to 1.010 × 10−7 S/m). Moreover, the T-P electrical conductivity values of the PP/CB and PP/CB/MWCNT were compared at the same conductive fillers content (15 wt%). The results showed that the T-P electrical conductivity of the PP/CB/MWCNT composites was far higher than that of the PP/CB composites by almost five orders of magnitude because the MWCNT acted as a bridge between CB particles, and a unique geometric shape was formed in the system. The T-P electrical conductivity of the foam PP/CB/MWCNT composites with 15 wt% carbon fillers was higher than that of the solid PP/CB composites with 20 wt% carbon fillers. This study reveals that the effect of foaming and the addition of hybrid fillers can improve the T-P electrical conductivity of plastic products, which is very important for the development of lightweight conductive plastics.
Spatial variation of groundwater response to multiple drivers in a depleting alluvial aquifer system, northwestern India
Authors: van Dijk Wout M , Densmore Alexander L , Jackson Christopher R , Mackay Jonathan D , Joshi Suneel K , Sinha Rajiv , Shekhar Shashank , Gupta Sanjeev
Published: September 2019

Unsustainable exploitation of groundwater in northwestern India has led to extreme but spatially variable depletion of the alluvial aquifer system in the region. Mitigation and management of groundwater resources require an understanding of the drivers behind the pattern and magnitude of groundwater depletion, but a regional perspective on these drivers has been lacking. The objectives of this study are to (1) understand the extent to which the observed pattern of groundwater level change can be explained by the drivers of precipitation, potential evapotranspiration, abstraction, and canal irrigation, and (2) understand how the impacts of these drivers may vary depending on the underlying geological heterogeneity of the system. We used a transfer function-noise (TFN) time series approach to quantify the effect of the various driver components in the period 1974–2010, based on predefined impulse response functions ( θ). The dynamic response to abstraction, summarized by the zeroth moment of the response M0, is spatially variable but is generally large across the proximal and middle parts of the study area, particularly where abstraction is high but alluvial aquifer bodies are less abundant. In contrast, the precipitation response is rapid and fairly uniform across the study area. At larger distances from the Himalayan front, observed groundwater level rise can be explained predominantly by canal irrigation. We conclude that the geological heterogeneity of the aquifer system, which is imposed by the geomorphic setting, affects the response of the aquifer system to the imposed drivers. This heterogeneity thus provides a useful framework that can guide mitigation efforts; for example, efforts to decrease abstraction rates should be focused on areas with thinner and less abundant aquifer bodies.
Common method bias in applied settings: The dilemma of researching in organizations
Authors: Jordan Peter J , Troth Ashlea C
Published: September 2019

Authors are experiencing increasing competition for their articles to be published. One way of ensuring their work is given the best chance of being published is to underpin their research with rigorous methods that are characterized by robustness, accuracy and reliability. A common factor that can stymie research rigour is common method bias. Our aim in this article is to outline the nature of, concerns about and examine reasons why researchers still conduct studies that are susceptible to common method bias. We also provide some solutions for avoiding or managing common method bias concerns. In doing this, we acknowledge the substantial work that has been produced on this topic to date and, therefore, focus our contribution specifically on issues that affect research in applied and managerial settings.

JEL Classification: C90, D23
Social Status and Marriages: An Investigation of Concepts and Practices in the Buddhist Textual Traditions
Authors: Roy Taniya
Published: September 2019

The production of the early Buddhist texts had a significant purpose of treasuring the teachings of the Buddha. The texts were in oral form and developed over a long time span. The period of composition and compilation of the texts witnessed magnanimous changes in terms of historical evolution and socio-political development in India. Several ethical principles in the form of the Buddha’s teachings made Buddhism popular heretical sect of the sixth century BCE. Buddhism propagated against the complex Vedic ritual practices but in no way tried to reform the Vedic structural framework. If carefully studied, the Buddhist ethos reveal an all pervasive attempt to create a resolution to the conflicts of the conventional society This becomes clear in light of many instances depicted in the early Buddhist texts. In this article, I would interrogate the role played by ‘social status’ in negotiating marriages and how that has been represented in the Jᾱtakas, Therīgāthā and Theragᾱthᾱ. How nuptial ties has been dealt in the Buddhist texts is significant because the description of the rituals which forms the central aspect in the occasion of the marriage between two individuals has been completely absent in the Buddhist textual narratives. Whereas most of the narratives in the Jᾱtakas are based on the description of householder’s life, the nuptial ties and complexities developed out of it. This article maps a comparative analysis of the Jᾱtakas, Therīgāthā and Theragᾱthᾱ for a better understanding of our shared past.
The Chinese in Calcutta: A Study on Settlement and Demographical Patterns
Authors: Bose Arpita
Published: September 2019

The present article will shed light on the settlement and demographic pattern of the Chinese community living in Calcutta over more than 200 years. The Calcutta Chinese settlement was one of the oldest if it is compared with the other settlements of them in other parts of South Asia. It also intends to focus on their arrival and the reasons behind their migration. The present article will also indicate the routes of migration and the evolution of their settlement in and around Calcutta.
Cocreating Meaning Through Expressive Writing and Reading for Cancer Caregivers
Authors: Leung Yvonne W. , Maslej Marta M. , Ho Clara , Razavi Shima , Uy Paul , Hosseini Mehr-Afarin , Avery Jonathan , Rodin Gary , Peterkin Allan
Published: September 2019

Purpose:

Caregivers of patients with cancer cope with socioemotional challenges, which can adversely affect their well-being. We developed an intervention, expressive writing and reading (EWR), to promote emotional processing and social connectedness among caregivers. In a single-arm pilot study, we assessed its feasibility and perceived usefulness.

Methods:

Caregivers participated in weekly 1.5-hour EWR workshops offered over 20 weeks. After 4 sessions, they completed semistructured interviews, which were analyzed using qualitative descriptive analysis.

Findings:

Of 65 caregivers approached, 25 were eligible, 18 consented, and 9 (50%) caregivers completed at least 4 workshops and the interview. Their responses revealed 3 themes: “inner processing,” “interpersonal learning,” and “enhanced processing and preparedness.” Perceived benefits of EWR included emotional and cognitive processing (individual and collaborative), learning from the emotions and experiences of other caregivers, and preparing for upcoming challenges.

Conclusions:

Expressive writing and reading can be a safe and cost-effective supportive intervention for caregivers of patients with cancer.
From Online Political Posting to Mansplaining: The Gender Gap and Social Media in Political Discussion
Authors: Koc-Michalska Karolina , Schiffrin Anya , Lopez Anamaria , Boulianne Shelley , Bimber Bruce
Published: September 2019

The gender dynamics of political discussion are important. These dynamics shape who shares their political views and how they share their views and reactions to these views. Using representative survey data from the United States and the UK, we investigate how social media platforms shape the gender dynamics of political posting. We find that on Facebook, gender does not predict political posting, whereas on Twitter, the gender gap is more pronounced. We also examine the concept of “mansplaining”—a term used to describe a patronizing form of communication directed at women by men. Firstly, we find that posting about political issues to Twitter is more likely to result in being an explainee but also being an explainer of political issues. Furthermore, posting to Twitter increases the likelihood of men reporting having been accused of mansplaining and women reporting having experienced it. In general, more than half of the women say they have experienced mansplaining, especially those who are younger, well educated, and left-leaning. We argue that the possibility of being mansplained affects who is willing to post their opinions online, and as such, caution should be exercised when using digital trace data to represent public opinion.
Book review: Alain Fayolle (Ed.), A Research Agenda for Entrepreneurship Education
Authors: Dwivedi Amit Kumar , Maitraya Shuchi
Published: September 2019

Alain Fayolle (Ed.), A Research Agenda for Entrepreneurship Education, MA, USA; Gloucestershire, UK: Edward Elgar Publishing, 2018, 309 pp.
Republished: Approaching the Evidence Basis for Aviation-Derived Teamwork Training in Medicine
Authors: Zeltser Marina V. , Nash David B.
Published: September 2019

The Institute of Medicine has suggested that training in team behavior, leadership, communication, and other human factors could reduce medical errors and improve patient safety. Training on such topics has been adapted from teamwork training programs used in military and commercial aviation, called crew resource management (CRM). The principles behind CRM programs have been deployed in a number of clinical settings over the past 2 decades, and there are now several CRM vendors. Little is known about this nascent industry, and the emerging research supporting CRM programs lacks standardization and conclusive evidence. The objectives of this study were to report on the body of empirical data about CRM training in clinical settings and to provide a conceptual framework for evaluating its effectiveness in medicine. Using the proposed conceptual framework, the authors further examine currently published methods of measuring effectiveness and identify future directions for the use of teamwork training in medicine.
Republished: What Is the Return on Investment for Implementation of a Crew Resource Management Program at an Academic Medical Center?
Authors: Moffatt-Bruce Susan D. , Hefner Jennifer L. , Mekhjian Hagop , McAlearney John S. , Latimer, RN, MS Tina , Ellison Chris , Scheck McAlearney Ann
Published: September 2019

Crew Resource Management (CRM) training has been used successfully within hospital units to improve quality and safety. This article presents a description of a health system-wide implementation of CRM focusing on the return on investment (ROI). The costs included training, programmatic fixed costs, time away from work, and leadership time. Cost savings were calculated based on the reduction in avoidable adverse events and cost estimates from the literature. Between July 2010 and July 2013, roughly 3000 health system employees across 12 areas were trained, costing $3.6 million. The total number of adverse events avoided was 735—a 25.7% reduction in observed relative to expected events. Savings ranged from a conservative estimate of $12.6 million to as much as $28.0 million. Therefore, the overall ROI for CRM training was in the range of $9.1 to $24.4 million. CRM presents a financially viable way to systematically organize for quality improvement.
Republished: Reduction in Central Line–Associated Bloodstream Infection Rates After Implementations of Infection Control Measures at a Level 3 Neonatal Intensive Care Unit
Authors: Dumpa Vikramaditya , Adler Bonny , Allen Delena , Bowman Deborah , Gram Amy , Ford Pat , Sannoh Sulaiman
Published: September 2019

Advances in neonatology led to survival of micro-preemies, who need central lines. Central line–associated bloodstream infection (CLABSI) causes prolonged hospitalization, morbidities, and mortality. Health care team education decreases CLABSIs. The objective was to decrease CLABSIs using evidence-based measures. The retrospective review compared CLABSI incidence during and after changes in catheter care. In April 2011, intravenous (IV) tubing changed from Interlink to Clearlink; IV tubing changing interval increased from 24 to 72 hours. CLABSIs increased. The following measures were implemented: July 2011, reeducation of neonatal intensive care staff on Clearlink; August 2011, IV tubing changing interval returned to 24 hours; September 2011, changed from Clearlink back to Interlink; November 2011, review of entire IV process and in-service on hand hygiene; December 2011, competencies on IV access for all nurses. CLABSIs were compared during and after interventions. Means were compared using the t test and ratios using the χ2 test; P <.05. CLABSIs decreased from 4.4/1000 to 0/1000 catheter-days; P < .05. Evidence-based interventions reduced CLABSIs.
Pediatric SJS/TEN Subdued by a Combination of Dexamethasone, Cyclosporine, and Etanercept
Authors: Coulombe Jérôme , Belzile Eugénie , Duhamel Amélie , Rault Pauline , Buteau Chantal , DeBruycker Jean-Jacques , Bussières Jean-François
Published: September 2019

We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epidermolysis without immediate or late onset complications.
Exposing children to pornography: How competing constructions of childhood shape state regulation of online pornographic material
Authors: Keen Caroline , France Alan , Kramer Ronald
Published: September 2019

This article discusses policy debates in the United Kingdom and Australia concerning the regulation of online pornographic content as it relates to children. Through a thematic analysis of qualitative interviews with key stakeholders at the negotiation table, we find that rather than positivist notions of the ‘developing’ and ‘vulnerable’ child dominating policy discourse, post-modern representations of the ‘savvy’ and ‘agentic’ child have come to dominate policy culture and outcomes. In this scenario, the regulatory role of states in providing media protection is diminished, while neoliberal forms of governance that emphasise the responsibility of individuals, including parents and children, have come to dominate the emerging policy landscape.
Between a Rock and a Hard Place: Preference Formation in France During the Eurozone Crisis
Authors: Fontan Clement , Saurugger Sabine
Published: September 2019

This article analyses the causal factors underlying the formation of French preferences during the Eurozone crisis solving process (2008–2017). Going beyond the clear distinction between national preference formation and interstate bargaining of liberal intergovernmentalism, this article combines new intergovernmentalism, political economy and feedback loops to study the horizontal linkages between different actors included in the process of domestic preference formation. Based on the Economic and Monetary Union (EMU) Choices dataset, which includes semi-structured interviews conducted with French policy-makers involved in the European Union negotiations at the highest level, we will concentrate on French preference formation in four negotiations at the European Union level: the 3 May 2010 agreement on bilateral loans to Greece, the initial capitalisation amount of the European Stability Mechanism, the negotiations on the legal nature of the ‘debt-brake’ included in the Treaty on Stability, Coordination and Governance and the reverse qualified majority voting procedure. The article shows that confidential and restricted administrative networks played a central role in reducing the uncertainty stemming from the fragile financial positions of the hypertrophied domestic banking system. At the same time, French negotiators find themselves between a rock and a hard place during negotiations at the European Union level, not crossing the red line fixed by Germany, on the one hand, and ensuring that policy solutions are compatible with governmental political stance and domestic economic interests, on the other hand. Contrary to recent research pointing out to the increasing influence of domestic public opinion on national preference formation, however, feedback loops between the outcome of the crisis solving process and French politics and policies had very little impact.
Changes in Skin Perfusion Pressure After Hyperbaric Oxygen Therapy Following Revascularization in Patients With Critical Limb Ischemia: A Preliminary Study
Authors: Nakamura Hideharu , Makiguchi Takaya , Atomura Daisuke , Yamatsu Yukie , Shirabe Ken , Yokoo Satoshi
Published: September 2019

Hyperbaric oxygen (HBO) therapy promotes wound healing in patients with ischemic disease; however, HBO-induced changes in skin peripheral circulation have not been evaluated in clinical practice. Here, we investigated these changes in patients with critical limb ischemia (CLI), with a focus on the angiosome of crural blood vessels with blood flow improved by endovascular therapy (EVT). Six patients with CLI and ulcers who were treated with HBO after EVT (7 limbs; 1 patient had ulcers in the bilateral limbs) and 3 healthy subjects (6 limbs) were enrolled. HBO therapy was performed at 2 atm under 100% oxygen for 90 min per session. Skin perfusion pressure (SPP) was measured in the dorsum and sole of the foot 1 hour before (pre-SPP) and after (post-SPP) HBO therapy. ΔSPP was calculated as post-SPP minus pre-SPP. SPP measurement regions were divided into those that did (direct region) and did not (indirect region) correspond to the vascular angiosome in which angiography findings of the crus were improved after EVT; i.e., when the anterior tibial artery was effectively treated with EVT, the dorsum was the direct region and the sole was the indirect region, and vice versa when the posterior tibial artery was treated. In the direct, indirect, and healthy subject groups, the ΔSPPs were 20.5±8.7 (p=0.002), –6.4±10.9, and –15.1±18.1 (p=0.014), respectively; that of the direct group was significantly greater than that of the other groups. These results suggest that short-term improvement of the peripheral circulation by HBO therapy was significant in patients with successful revascularization.
Minimally Invasive Sutureless Aortic Valve Replacement is Associated With Improved Outcomes in Patients With Left Ventricular Dysfunction
Authors: Concistrè Giovanni , Bianchi Giacomo , Chiaramonti Francesca , Margaryan Rafik , Marchi Federica , Kallushi Enkel , Solinas Marco
Published: September 2019

Objective

Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis compared with patients with preserved LVEF. To evaluate the impact of sutureless Perceval (LivaNova, Italy) aortic bioprosthesis on LVEF and clinical outcomes in patients with baseline left ventricular (LV) dysfunction who underwent isolated aortic valve replacement (AVR).

Methods

Between March 2011 and August 2017, 803 patients underwent AVR with Perceval bioprosthesis implantation. Fifty-two isolated AVR had preoperative LVEF ≤45%. Mean age of these patients was 77 ± 6 years, 24 patients were female (46%), and mean EuroSCORE II was 9.4% ± 4.8%. Perceval bioprosthesis was implanted in 9 REDO operations. In 43 patients (83%), AVR was performed in minimally invasive surgery with an upper ministernotomy ( n = 13) or right anterior minithoracotomy ( n = 30).

Results

One patient died in hospital. Cardiopulmonary bypass and aortic cross-clamp times were 85.5 ± 26 minutes and 55.5 ± 19 minutes, respectively. At mean follow-up of 33 ± 20 months (range: 1 to 75 months), survival was 90%, freedom from reoperation was 100%, and mean transvalvular pressure gradient was 11 ± 5 mmHg. LVEF improved from 37% ± 7% preoperatively to 43% ± 8% at discharge ( P < 0.01) and further increased to 47% ± 9% at follow-up ( P = 0.06), LV mass decreased from 149.8 ± 16.9 g/m2 preoperatively to 115.3 ± 11.6 g/m2 at follow-up ( P < 0.001), and moderate paravalvular leakage occurred in 1 patient without hemolysis not requiring any treatment.

Conclusions

AVR with sutureless aortic bioprosthesis implantation in patients with preoperative LV dysfunction demonstrated a significant immediate and early improvement in LVEF.
Find your tribe! Early childhood educators defining and identifying key factors that support their workplace wellbeing
Authors: Jones Catherine , Hadley Fay , Waniganayake Manjula , Johnstone Melissa
Published: September 2019

Historically, research on educator wellbeing has focused on ill health including stress, burnout and emotional exhaustion. There is a dearth of research examining healthy workplace wellbeing among early childhood educators, which makes developing strategies to support their wellbeing difficult. Moreover, there is a lack of clarity about the concept of educator workplace wellbeing and a lack of understanding of the complex interplay between factors supporting and thwarting wellbeing within long day-care centres. This two-phase study used a mixed-methods research design. Presented in this paper are the findings from phase one. Semi-structured in-depth interviews with 22 early childhood educators in long day-care centres reflected on educator workplace wellbeing as a broad concept encompassing social, emotional, physical and economic factors. Educator ‘voices’ provided insight into the individual, relational and contextual elements impacting on their personal workplace wellbeing.
2018: A watershed year for psychedelic science
Authors: Aday Jacob S , Davoli Christopher C , Bloesch Emily K
Published: September 2019

While interest in the study of psychedelic drugs has increased over much of the last decade, in this article, we argue that 2018 marked the true turning point for the field. Substantive advances in the scientific, public, and regulatory communities in 2018 significantly elevated the status and long-term outlook of psychedelic science, particularly in the United States. Advances in the scientific community can be attributed to impactful research applications of psychedelics as well as acknowledgement in preeminent journals. In the public sphere, Michael Pollan’s book How to Change Your Mind was a commercial hit and spurred thought-provoking, positive media coverage on psychedelics. Unprecedented psychedelic ballot initiatives in the United States were representative of changes in public interest. Finally, regulatory bodies began to acknowledge psychedelic science in earnest in 2018, as evidenced by the designation of psilocybin-assisted psychotherapy to “breakthrough therapy” status for treatment-resistant depression by the U.S. Food and Drug Administration (FDA). In short, 2018 was a seminal year for psychedelic science.
A foot drop compensation device based on surface multi-field functional electrical stimulation—Usability study in a clinical environment
Authors: Imatz-Ojanguren Eukene , Sánchez-Márquez Gema , Asiain-Aristu Jose Ramón , Cueto-Mendo Joxean , Jaunarena-Goicoechea Edurne , Zabaleta Haritz , Keller Thierry
Published: September 2019

Introduction

Functional electrical stimulation applies electrical pulses to the peripheral nerves to artificially achieve a sensory/motor function. When applied for the compensation of foot drop it provides both assistive and therapeutic effects. Multi-field electrodes have shown great potential but may increase the complexity of these systems. Usability aspects should be checked to ensure their success in clinical environments.

Methods

We developed the Fesia Walk device, based on a surface multi-field electrode and an automatic calibration algorithm, and carried out a usability study to check the feasibility of integrating this device in therapeutic programs in clinical environments. The study included 4 therapists and 10 acquired brain injury subjects (8 stroke and 2 traumatic brain injury).

Results

Therapists and users were “very satisfied” with the device according to the Quebec User Evaluation of Satisfaction with Assistive Technology scale, with average scores of 4.1 and 4.2 out of 5, respectively. Therapists considered the Fesia Walk device as “excellent” according to the System Usability Scale with an average score of 85.6 out of 100.

Conclusions

This study showed us that it is feasible to include surface multi-field technology while keeping a device simple and intuitive for successful integration in common neurorehabilitation programs.
Endovascular treatment of extradural internal carotid artery aneurysm with a flow diverter stent
Authors: Rautio Riitta , Sinisalo Matias , Helmiö Päivi
Published: September 2019

Extradural internal carotid artery aneurysms are rare and the indications for treatment are not well defined. We report successful management of two high extradural internal carotid artery aneurysms treated with flow diverter stents. The endovascular repair of extradural internal carotid artery aneurysms is effective because with surgical treatment there is always the possibility of cranial nerve injury.
Smart but Evil? Student-Teachers’ Perception of Educational Researchers’ Epistemic Trustworthiness
Authors: Merk Samuel , Rosman Tom
Published: September 2019

In-service and preservice teachers are increasingly required to integrate research results into their classroom practice. However, due to their limited methodological background knowledge, they often cannot evaluate scientific evidence firsthand and instead must trust the sources on which they rely. In two experimental studies, we investigated the amount of this so-called epistemic trustworthiness (dimensions expertise, integrity, and benevolence) that student-teachers ascribe to the authors of texts who present classical research findings (e.g., learning with worked-out examples) that allegedly were written by a practitioner, an expert, or a scientist. Results from the first exploratory study suggest that student-teachers view scientists as “smart but evil,” since they rate them as having substantially more expertise than practitioners, while also being less benevolent and lacking in integrity. Moreover, results from the exploratory study suggest that evaluativistic epistemic beliefs (beliefs about the nature of knowledge) predict epistemic trustworthiness. A preregistered conceptual replication study (Study 2) provided more evidence for the “smart but evil” stereotype. Further directions of research as well as implications for practice are discussed.
How to Create and Use State-Level Policy Data Sets in Education Research
Authors: Kelchen Robert , Rosinger Kelly Ochs , Ortagus Justin C.
Published: September 2019

As state governments seek to improve the performance of institutions of K–12 and higher education, they often adopt educational policies that have similar names but different characteristics across states and with variations over time within states. Yet quantitative analyses generally examine the absence or presence of an educational policy instead of diving into details such as the dosage or percentage of funding tied to a policy or the specific groups being targeted by the implementation of the policy. The aim of this article is to provide guidance for education policy researchers in constructing and analyzing detailed data that can inform the design of state-level policies, using state performance-based funding policies in public higher education as an example. We also show how to conduct difference-in-differences analyses with continuous treatment variables in order to take advantage of more-nuanced data and better understand the context in which policies are effective (or ineffective).
Regular Low-Dose Oral Metronidazole Is Associated With Fewer Vesicovaginal and Rectovaginal Fistulae in Recurrent Cervical Cancer: Results From a 10-Year Retrospective Cohort
Authors: George Reena , Prasoona Thotampuri Shanthi , Kandasamy Ramu , Mani Thenmozhi , Murali Shakila , Rekha Roja , Muliyil Jayaprakash
Published: September 2019

PURPOSE

Anaerobic necrosis in cervical cancer can lead to malodor, fistulae, and treatment abandonment. In this retrospective cohort study, we examined the association between maintenance metronidazole and the incidence of malignant fistulae in recurrent cervical cancer.

METHODS

We screened all cervical cancer records registered between 2007 and 2016 in the local palliative care database at Christian Medical College, Vellore, India. There were 208 eligible patients with post-treatment residual/recurrent pelvic disease. Among them, 76 had received oral maintenance metronidazole 200 mg once per day for 2 to 86 weeks (interquartile range, 4-16 weeks).

RESULTS

Seventy-two patients developed at least one fistula. Forty-nine had vesicovaginal fistulae, 10 had rectovaginal fistuale, and 13 developed both types of fistulae. Patients on maintenance metronidazole had fewer fistulae (22.4% v 41.7%; P = .005), a longer median fistula-free survival (42.9 months v 14.1 months; P < .001), and a postrecurrence survival of 11.5 months versus 8.7 months ( P = .112). We performed Cox multivariable proportional hazards regression analysis on the data from the subset of 146 patients observed until death. Bladder/rectal infiltration had a higher risk of fistula (HR, 5.24; P = .011), whereas distant metastases (HR, 2.46; P = .012) and Eastern Cooperative Oncology Group performance status greater than 1 (HR, 1.64; P = .008) were associated with a higher risk of death. Maintenance metronidazole was associated with a lower risk of fistula (hazard ratio [HR], 0.33; 95% CI, 0.16 to 0.67; P = .002) and a lower risk of death (HR, 0.56; 95% CI, 0.39 to 0.81; P = .002).

CONCLUSION

Our data indicate that there is a significant inverse association between oral maintenance metronidazole and malignant fistulae in locally recurrent cervical cancer. The impact of this simple intervention on pelvic symptoms, fistulae, and survival should be evaluated in prospective studies.
Cardiovascular health and the menopausal woman: the role of estrogen and when to begin and end hormone treatment
Authors: Naftolin Frederick , Friedenthal Jenna , Nachtigall Richard , Nachtigall Lila
Published: September 2019

Reports have correlated the use of estrogen for the treatment of menopausal symptoms with beneficial effects on the cardiovascular system. Molecular, biochemical, preclinical, and clinical studies have furnished a wealth of evidence in support of this outcome of estrogen action. The prospective randomized Women’s Health Initiative (WHI) and the Early Versus Late Intervention Trial (ELITE) showed that starting menopausal hormone treatment (MHT) within 5 to 10 years of menopause is fundamental to the success of estrogen’s cardioprotection in post-menopausal women without adverse effects. Age stratification of the WHI data has shown that starting hormone treatment within the first decade after menopause is both safe and effective, and the long-term WHI follow-up studies are supportive of cardioprotection. This is especially true in estrogen-treated women who underwent surgical menopause. A critique of the WHI and other relevant studies is presented, supporting that the timely use of estrogens protects against age- and hormone-related cardiovascular complications. Salutary long-term hormone treatment for menopausal symptoms and prevention of complications has been widely reported, but there are no prospective trials defining the correct length to continue MHT. At present, women undergoing premature menopause receive estrogen treatment (ET) until evidence of hormone-related complications intervenes. Normal women started on MHT who receive treatment for decades without hormone-related complications have been reported, and the WHI follow-up studies are promising of long-term post-treatment cardioprotection. A prevention-based holistic approach is proposed for timely and continuing MHT/ET administration as part of the general management of the menopausal woman. But this should be undertaken only with scheduled, annual patient visits including evaluations of cardiovascular status. Because of the continued occurrence of reproductive cancers well into older ages, these visits should include genital and breast cancer screening.
Extended indications for varicocelectomy
Authors: Machen G. Luke , Sandlow Jay I.
Published: September 2019

The relationship between varicoceles and subfertility is well-established, but recent evidence suggests that varicoceles may cause global testicular dysfunction. This has led to exploration into expanding the indications for varicocelectomy. This review examines the literature regarding varix ligation as a treatment for non-obstructive azoospermia, elevated DNA fragmentation, and hypogonadism.
Patent Trolls: Evidence from Targeted Firms
Authors: Cohen Lauren , Gurun Umit G. , Kominers Scott Duke
Published: September 2019

We provide the first large-sample evidence on the behavior and impact of nonpracticing entities (NPEs) in the intellectual property space. We find that, on average, NPEs appear to behave as opportunistic “patent trolls.” NPEs sue cash-rich firms and target cash in business segments unrelated to alleged infringement at essentially the same frequency as they target cash in segments related to alleged infringement. By contrast, cash is neither a key driver of intellectual property lawsuits by practicing entities (e.g., IBM and Intel) nor of any other type of litigation against firms. We find further suggestive evidence of NPE opportunism: targeting of firms that have reduced ability to defend themselves, repeated assertions of lower-quality patents, increased assertion activity nearing patent expiration, and forum shopping. We find, moreover, that NPE litigation has a real negative impact on innovation at targeted firms: firms substantially reduce their innovative activity after settling with NPEs (or losing to them in court). Meanwhile, we neither find any markers of significant NPE pass-through to end innovators, nor of a positive impact of NPEs on innovation in the industries in which they are most prevalent.

This paper was accepted by Tyler Shumway, finance.
Um Jardim em Floresta
Authors: Tavares Claudia
Published: September 2019

A tese articula arte e natureza sob a égide do elemento água e do conceito de jardim. É uma pesquisa que se inicia dentro de um ateliê no Rio de Janeiro e planta um jardim no sertão de Pernambuco. A hipótese central é de que a natureza assume o lugar de parceria em trabalhos de arte contemporânea.  Palavras chave: água, ateliê-mina, jardim, natureza    Abstract: The thesis articulates art and nature under the aegis of the water element and the concept of garden. It is a research that begins inside a studio in Rio de Janeiro and plants a garden in the dry backlands of Pernambuco. A central hypothesis is that nature acts as a partner in relation to works of contemporary art.   Key-words: water, studio-mine, garden, nature
A produção resistência das práticas conceitualistas: uma perspectiva decolonial sobre o estudo da arte
Authors: Carpanedo Carlini Lara
Published: September 2019

Tendo em vista o debate sobre a permanência da matriz colonial do poder na América Latina e as contribuições de autores como Mari Carmen Ramírez, Walter Mignolo e Michel Foucault, buscamos sustentar a perspectiva de que as práticas conceitualistas latino-americanas produziriam resistência frente essa matriz, disparando processos de decolonização da arte, do ser.Palavras-chave: Conceitualismos latino-americanos; Decolonialidade; Resistência.Abstract: Considering the debate towards the permanence of the colonial matrix of power in Latin America and the contributions of authors like Mari Carmen Ramírez, Walter Mignolo and Michel Foucault, we seek to sustain the perspective that Latin American conceptualist practices would produce resistance against this matrix, firing processes of decolonization of art, of being.Keywords: Latin American conceptualisms; Decoloniality; Resistance.
Economia da Energia Vital: Arte e movimentos da transição
Authors: Moura Lívia
Published: September 2019

Através dos conceitos e ações do coletivo Vendo Ações Virtuosas, o artigo trata de movimentos contemporâneas no campo da economia e da arte, que apontam tendências para uma transição global. Onde a matéria, assim como o produtivismo e o objeto artístico deixam de ser a base fundamental dessas estruturas para dar lugar a ações, proposições, desmaterializações, energias sutis e vitais. Abstract:Through the concepts and actions of the collective Seeing Virtuous Actions, the article deals with contemporary movements in the field of economics and art, which point to trends for a global transition. Where matter, as well as productivism and the artistic object, cease to be the fundamental basis of these structures to give rise to actions, propositions, dematerializations, subtle and vital energies.Palavras-chave: decrescimento econômico, energia vital, transição e arte contemporânea.Key words: degrowth economy, vital energy, transition and contemporary art
Mulher-casa, mulher-faca
Authors: Menezes Priscilla
Published: September 2019

RESUMO: Historicamente, feminino está relacionado à incompletude e incompletude à falta. Nesse ensaio, entretanto, incompletude é apresentada como condição necessária à criação  e o feminino como uma via de acesso ao pensamento poético. As séries Femme-couteau e Femme-maison de Louise Bourgeois são apresentadas a partir da relação dialética entre cortar/rachar/romper e acolher/gestar/criar.Palavras-chave: Feminino, Louise Bourgeois, hospitalidade, pensamento poético.ABSTRACT: Historically, feminine has been related to incompleteness and incompleteness to lack. In this essay, however, incompleteness is presented as the necessary condition for creation and the feminine as a way of access to poetic thought. The series Femme-couteau and Femme-maison by Louise Bourgeois are presented through the dialectic relation between cut/split/break and host/generate /create.Key-words: Feminine, Louise Bourgeois, hospitality, poetic thought.
Managing chronic, nonhealing wounds stalled in the inflammatory phase: a case series using a novel matrix therapy, CACIPLIQ20
Authors: Irving Sally
Published: September 2019

One of the biggest challenges faced by healthcare providers is the treatment of chronic, non-healing wounds. This paper reports for the first time in the UK the results of five case studies in which a novel regenerating matrix-based therapy, CACIPLIQ20, was used. CACIPLIQ20 is a heparan sulphate mimetic designed to replace the destroyed heparan sulphate in the extracellular matrix of wound cells. All five patients in this case series had chronic, non-healing ulcers that had not improved with conventional care. Treatment included two applications of CACIPLIQ20 per week, for a maximum of 12 weeks. Three of the five wounds healed completely, and the remaining two showed significant improvements in size and quality. The treatment was well tolerated by the patients and also led to a significant reduction in pain. Moreover, CACIPLIQ20 treatment was found to be highly cost-effective when compared to conventional care, with the potential to save healthcare systems significant resources. Further studies are needed to build a strong evidence base on the use of this product, but these preliminary findings are certainly promising.
Be clear on ‘intent’
Authors: Allingham Sue
Published: September 2019

This is the first of a series of three articles which will explore the new inspection frameworks for early years and schools to see exactly what the implications are for practice and provision in the EYFS.
See learning through the lens of the individual child
Authors: Siraj-Blatchford John , Brock Lynette
Published: September 2019

Every child will come to nursery or pre-school with different life experiences. Understanding these is key to giving them activities that build on what they already know, enabling the joy of learning to evolve.
Steiner-Waldorf today
Authors: Suggate Sebastian , Suggate Tamara
Published: September 2019

Since the opening of Steiner-Waldorf's first school 100 years ago, there are now more than 1,000 schools and 2,000 kindergartens in more than 64 countries. In this book extract, authors Sebastian and Tamara Suggate outline key aspects of its practice today.
Ten in the Bed
Authors: Hewson Claire
Published: September 2019

Penny Dale's picture book featuring the popular rhyme is alive with onomatopoeia and crammed with detail, making it a great stimulus for counting backwards and learning to take away one from any number to ten.
Seed of an idea
Authors: Hart Karen
Published: September 2019

Take a closer look at natural plant forms and use these shapes and properties to create pictures and sculptures. As children experiment with art techniques they will also be learning about the natural world.
Saving every drop
Authors: White Hilary
Published: September 2019

Try these literacy-based activities and combine the development of children's reading and information gathering skills with learning about water conservation. Helping them to discover the importance of water is a good starting point.
Centralised versus decentralised subnational debt and soft budget constraint: evidence from China
Authors: An Zhiyong , Hou Yilin
Published: September 2019

This article examines the causal effect of debt decentralisation on the budget constraint of subnational governments. China’s debt decentralisation reform of 2011 authorised four provincial-level units to issue debt on their own, but not the remaining ones. Using data on the budgetary expenditure and revenue of Chinese subnational governments from 2009 to 2014, we estimate the effect of the reform with a difference-in-differences approach, with those four provincial units as the treatment group and the others as the control group. Our findings suggest that debt decentralisation can help harden the budget constraint of subnational governments.
Freaks of History
Authors: MacDonald James
Published: September 2019

Disability studies have long been the domain of medical and pedagogical academics. However, in recent years, the subject has outgrown its clinical origins. In Freaks of History, James MacDonald presents two dramatic explorations of disability within the wider themes of sexuality, gender, foreignness and the Other. Originally directed by Martin Harvey and performed by undergraduate students at the University of Exeter, Wellclose Square and Unsex Me Here analyse cultural marginalization against the backdrop of infamous historical events.

MacDonald, who is cerebral palsied, recognizes that disability narratives are rarely written by and for disabled people. Therefore, his plays, accompanied by critical essays and director’s notes, are a welcome addition to the emerging discourse of Crip theory and essential reading for disability students and academics alike.
Quality of sibling relationship and parental differential treatment in a sample of Portuguese adolescents
Authors: Relva Inês Carvalho , Alarcão Madalena , Fernandes Otília Monteiro , Graham-Bermann Sandra
Published: September 2019

Os irmãos são extremamente importantes na vida do adolescente. Com este estudo tivemos por objetivo explorar de que modo estão relacionados a vinculação entre irmãos, o tratamento parental diferenciado e o uso de táticas resolução de conflito no relacionamento entre irmãos. Numa amostra de 192 adolescentes portugueses, 64.6% do sexo feminino, com idades compreendidas entre os 11 e os 16 anos, aplicou-se o Inventário de Vinculação na Adolescência (versão irmãos), as Escalas de Táticas do Conflito Revisadas (versão irmãos) e o Inventário de Experiências Diferenciadas entre Irmãos. Os resultados mostram que um tratamento parental igualitário está associado à maneira positiva de resolver os conflitos entre irmãos; o sexo masculino relatou maior distanciamento entre irmãos do que o sexo feminino, e uma relação negativa entre irmãos parece influenciar a ocorrência de violência entre estes. Este estudo enfatiza a importância de pais e profissionais de saúde promoverem precocemente a proximidade entre irmãos.
[RESENSI] Belajar dari Hubungan Islam-Kristen: Upaya Menciptakan Masa Depan Harmonis
Authors: Syarifudin Azis Pajri
Published: September 2019

Judul buku:  Sejarah Perjumpaan Islam-Kristen: Titik Temu dan Titik Seteru Dua Komunitas Agama Terbesar di DuniaPenulis:  Hugh GoddardPenerbit:  Serambi Ilmu SemestaKota Terbit:  JakartaTahun terbit:  Cetakan I, 2013Tebal halaman:  402 + Cover
POSISI DAN PERAN IBRAHIM MENURUT ISLAM
Authors: Djam’annuri Mr
Published: September 2019

Once a year, on the occasion of  celebrating the Feast of  Sacrifice (‘ Îd al-Adlhâ ) or at the time of Hajj, the Prophet Ibrahim as if “life” in the midst of  the Muslims through the repetition of a portion of  his life history. The recognition of the Muslims to the Prophet Ibrâhîm nearly as familiar with their recognition to the Prophet Muhammad. In Islam, he has a very important position and role. He is not only believed to be a prophet who has certain privileges, but also be a good example and model, especially in his obe- dience to Allah, his sincerity in religion, and his persistence in holding the principle of the oneness of Allah.However, the Qur’an, the main source of Islam, does not provide a detailed and chronological story about him but only a sort of fragments that could be considered off each other, but it all revolves around the fundamental religious attitude of Abraham as a Muslim, Hanîf, and away from polytheism. A detailed story of  Abraham is usually equipped with sources outside the Qur’an, both originating from Muslim writers or derived from sources that are usually refer red to Isrâîliyyât stories, including the stories of  Abraham contained in the Old Testament.
[RESENSI] SIAPA MENCARI MOKSA?
Authors: Chotimah Chusnul
Published: September 2019

Judul Buku: SiddharthaPenulis: Hermann HessePenerbit: PT Gramedia Pustaka UtamaCetakan: 2014Penerjemah: Gita YulianiTebal: 168 hlm; 20 cm
AHMADIYYA AND PEACEFUL-COEXISTENCE; GROUNDING TOLERANCE IN THE MIDDLE OF MINORITY GROUP
Authors: Almujaddidy Ali Ilham
Published: September 2019

Ahmadiyya came into the world on a mission of peace and renewal through the values of morality teachings. In the context of Indonesia, Ahmadis have been coming to the archipelago through the youth of Sumatra since 1924 and has received positive responses as a new religious movement at that time. But in its development, the phenomenon of Ahmadiyya emerged as an issue of protracted conflicts and endless until today. Some of the group that is the true Islam with shouts of Allahu Akbar carried out the attack against Ahmadiyya in Indonesia, including Ahmadiyya in Manis Lor, Kuningan.