bluuebunny/crossref_metadata_2025 huggingface dataset:
Low Radiation Doses in Oncocytic Lesions of the Parotid Gland: A Double-edged Sword. A Comprehensive Review
Authors: Pontoriero Antonio , Critelli Paola , Zeppieri Marco , Brogna Anna , Angileri Filippo Flavio , Bottari Antonino , Stagno Alberto , Parisi Silvana , Pergolizzi Stefano
Published: August 2024

Oncocytic lesions represent a group of benign and potentially precancerous tumors characterized by the accumulation of oncocytes, which are large, granular, and eosinophilic cells. Diagnosing oncocytic lesions in the parotid gland typically involves a combination of imaging techniques, such as ultrasound, Computed Tomography (CT) scans, and Magnetic Resonance Imaging (MRI). Fine-needle aspiration (FNA) biopsy with histopathological examination remains the primary diagnostic tool for these lesions. Accurate diagnosis is crucial for appropriate management decisions. 
Treatment options for oncocytic lesions in the parotid gland include surgery, conservative management, and radiation therapy (RT). However, in the head and neck region, radiation doses can be a double-edged sword. While RT is a treatment modality, low radiation doses can promote the development of oncocytic lesions in the parotid gland. The prognosis for patients with oncocytic lesions is generally favorable, especially when the lesions are benign and appropriately managed. 
Current research focuses on the molecular mechanisms underlying oncocytic lesions in response to low-dose radiation exposure. The development of these lesions following low radiation doses represents a significant clinical concern. This manuscript provides a comprehensive overview of the current knowledge regarding oncocytic lesions in the parotid gland, including risk factors, diagnosis, treatment options, and ongoing research, offering valuable insights for clinicians and researchers.
Analysis of Risk Factors for Surgical Treatment of Acute Female Pelvic Inflammatory Disease
Authors: Chen Xu-Wei , Zhu Ye-Qin , Yu Ping , Du Jun-Qiang , Li Hua-Qing
Published: August 2024

AIM: To investigate the incidence and high-risk factors associated with the surgical treatment of acute female pelvic inflammatory disease (PID). 
METHODS: A retrospective analysis was conducted on all inpatients diagnosed with acute female PID, encompassing conditions such as endometritis, salpingitis, tubo-ovarian abscess, ovarian abscess, and pelvic peritonitis, at Dongyang Hospital of Wenzhou Medical University from January 2013 to December 2021. Patients were categorized into two groups: the surgery group (n = 58) and the non-surgery group (n = 399), based on the necessity of surgical intervention (refer to Materials and Methods for surgical indications). Collected data included patient demographics (age, body mass index (BMI)), comorbidities (hypertension, diabetes mellitus), initial laboratory findings upon admission (white blood cell count, absolute neutrophil count, hemoglobin, platelet count, blood urea nitrogen/creatinine, prothrombin time (PT), international normalized ratio (INR), fibrinogen, albumin), surgical records, and postoperative pathology. Univariate and multivariate logistic regression analyses were conducted to ascertain the risk factors associated with the surgical treatment of acute female PID. 
RESULTS: Out of 457 hospitalized patients with acute female PID, 58 cases (12.7%) required surgical intervention. Univariate and multivariate logistic regression analyses indicated that advancing age correlated with an increased likelihood of surgical intervention in women with acute PID (odds ratio (OR) = 1.052, 95% Confidence Interval (CI) 1.022–1.082, p = 0.001). Additionally, lower serum albumin levels upon admission were associated with a heightened risk of surgery (OR = 0.913, 95% CI 0.859–0.970, p = 0.003), while elevated fibrinogen levels amplified the risk of surgical intervention in these patients (OR = 1.193, 95% CI 1.008–1.411, p = 0.04). 
CONCLUSIONS: Elderly women diagnosed with acute PID, especially those presenting with abscess formation, should undergo prompt surgical intervention if they display high-risk factors such as low albumin levels and elevated fibrinogen levels upon admission.
Endograft Collapse after Standard Endovascular Aneurysm Repair Implantation: A Report of Two Cases
Authors: Palughi Martina , Stella Nazzareno , Colonna Giulia , Schioppa Annalisa , Rizzo Luigi , Taurino Maurizio , Sirignano Pasqualino
Published: August 2024

Endovascular aneurysm repair (EVAR) has emerged as the preferred treatment for abdominal aortic aneurysm (AAA), offering advantages such as reduced mortality, faster recovery, and fewer complications compared to open repair (OR). However, concerns persist regarding long-term durability, and the need for reinterventions. Among all reported EVAR complications, endograft collapse poses a significant challenge, particularly when presenting with acute lower limb ischemia (ALI).  
The aim of this report is to describe two cases of non-dissection-related abdominal endograft collapse manifesting as ALI, requiring urgent intervention, emergent conversion to OR and complete endograft removal.
Effect of a Percutaneous Screw Guide on Screw Placement for Posterior Talar Fractures
Authors: Wang Hua , Ying Jichong , Liu Jianlei , Yu Tianming , Huang Dichao
Published: August 2024

AIM: This study aimed to evaluate the hypothesis that the utilization of percutaneous screw guides enhances the precision of screw placement in the surgical fixation of talar fractures. 
METHODS: Computed tomography (CT) scans of ankle joints were obtained from 40 healthy adults and 10 cadaveric specimens between April 2019 and August 2020 at Ningbo No. 6 Hospital. The acquired CT data were imported into  Materialise Interactive Medical Image Control System (MIMICS) software for processing. Three-dimensional (3D) digital models of the ankle joints were reconstructed, and relevant anatomical parameters were measured. A percutaneous screw guide (PSG) was designed and fabricated to facilitate accurate screw placement in the posterior talar process. Ten eligible cadaveric ankle joints were selected for further analysis and their 3D models were reconstructed using the MIMICS software. Screw trajectory parameters were then measured and analyzed based on these cadaveric models, forming the model group for comparative analyses. Ten cadaveric specimens were utilized in this study, equally divided into two groups: a guider group (n = 5) and a free-hand group (n = 5). In the guider group, talar posterior process screws were inserted using percutaneous screw guidance. In the free-hand group, screws were inserted into the talar posterior process without guidance. Post-operative CT scans were performed on all specimens. The following parameters were quantitatively compared between the two groups: screw trajectories, entry point distances in specimens with preselected screws, entry point distance trajectories in the 3D model, operation time, frequency of fluoroscopic imaging, and number of drilling attempts. 
RESULTS: Following the generation of the 3D models from 10 cadavers, a virtual screw was digitally inserted into each model. In the model group, the preselected screw trajectory was oriented towards the medial aspect of the talar neck base, with a cephalad inclination angle (CIA) of 3.1° ± 1.5° in the transverse~plane and a medial diverge angle (MDA) of 12.0° ± 1.4° in the coronal plane. The CIA and MDA of the screw trajectory in the guider group were 2.1° ± 1.7° and 11.2° ± 1.6°, respectively, whereas the CIA and MDA in the free-hand group were 6.0° ± 2.2° and 18.8° ± 1.6°, respectively. Statistical analysis revealed significant differences in both CIA and MDA between the two groups (p < 0.05). Furthermore, the guider group yielded superior outcomes in terms of entry point distance, operation time, fluoroscopic exposure time, and number of drilling attempts compared to the free-hand group (p < 0.05). 
CONCLUSIONS: Percutaneous screw guidance can improve the accuracy and safety of the posterior process of the talar screws, which can be feasible for percutaneous fixation. Further studies are required to confirm the efficacy and clinical outcomes of percutaneous screw guidance.
Effect of Intraspinal Anesthesia on Postoperative Recovery in Elderly Patients with Acute Appendicitis: A Retrospective Study
Authors: Sun Xiaohua , Zhang Jizheng , Li Yi , Che Jinli , Ren Wanlu
Published: August 2024

AIM: Acute appendicitis is a common disease in the elderly. Exploring a suitable anesthesia method is crucial in promoting postoperative recovery in elderly patients. Therefore, this study aimed to investigate the clinical effect of intraspinal anesthesia in elderly patients with appendicitis. 
METHODS: This study included the clinical data of 217 elderly patients with acute appendicitis who underwent laparoscopic appendectomy (LA) at Tianjin Hospital of Tianjin University from January 2022 to January 2023. After excluding 8 patients who did not meet the inclusion criteria, the data from 209 patients were retrospectively analyzed. Based on the different anesthesia methods, the study participants were divided into a reference group (n = 106) and a study group (n = 103). We compared the heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), diastolic blood pressure (DBP), blood oxygen saturation (SaO2), operation duration, hospitalization costs, discharge time, postoperative adverse reactions, inflammatory factor levels, Visual Analogue Scale (VAS) score, recovery time of intestinal peristalsis, anal exsufflation time, out-of-bed time, and incidence of postoperative complications between the two experimental groups. 
RESULTS: We observed that the study group exhibited higher levels of HR, RR, SBP, DBP, and SaO2 compared to the reference group (p < 0.001). However, there was no difference in operation time between the two groups (p > 0.05). The study group showed lower hospitalization cost and shorter discharge time than the reference group (p < 0.001). Similarly, the study group had lower incidence of postoperative adverse reactions than reference group (p < 0.05). There were no significant differences in the levels of C-reactive protein, interleukin-6, and tumor necrosis factor-α between the two groups before and after surgery (p > 0.05). Furthermore, the study group had a lower VAS score compared to the reference group at 3 h, 6 h and 12 h after surgery (p < 0.001). The recovery time of intestinal peristalsis, anal exsufflation time, and out-of-bed time in the study group were substantially shorter than the reference group (p < 0.001). Additionally, there was no difference in the incidence of postoperative complications between the two groups within 1 year after surgery (p < 0.001). 
CONCLUSIONS: Intraspinal anesthesia, as a safe anesthesia method, can reduce the discharge time of elderly patients with acute appendicitis who underwent LA, and reduce the occurrence of adverse reactions, and is beneficial for postoperative recovery.
A Comparative Study of Retrograde Intrarenal Surgery versus Percutaneous Nephrolithotomy for the Management of Staghorn Renal Calculi
Authors: Xu Xiang , Liao Sucai , Wei Genggeng , Xu Feihong , Jiang Yi , Lu Zhengquan , Xiong Lin
Published: August 2024

AIM: The indications for performing retrograde intrarenal surgery (RIRS) have increased. However, no comparative studies have been conducted on the treatment of staghorn renal calculi using RIRS and percutaneous nephrolithotomy (PCNL). We aimed to compare the effectiveness and safety of RIRS and PCNL as treatments for staghorn renal calculi. 
METHODS: We conducted a retrospective analysis of patients with staghorn renal calculi who underwent either PCNL or RIRS at our hospital from January 2021 to July 2023. Patients with staghorn renal calculi and renal malformation, as well as those with interrupted treatment or irregular follow-up, were excluded from the study. We compared the perioperative outcomes and complications between the groups. 
RESULTS: Fifty patients were included in the RIRS group, whereas 48 patients were included in the PCNL group. 1. No significant differences were observed between the groups regarding the number of complete staghorn calculi, stone size, age, sex, or other demographic characteristics. 2. RIRS was associated with a shorter postoperative hospitalization time (2.14 ± 0.76 vs. 5.15 ± 1.98 days, p < 0.001). 3. RIRS was associated with a decrease in hemoglobin (0.1 [0, 0.2] vs. 0.65 [0.4, 1] g/dL, p < 0.001) and a lower pain score (1 [1, 2] vs. 2 [1, 3], p = 0.008). 4. Compared with PCNL, RIRS did not significantly differ in terms of the 1-stage stone-free rate (50% vs. 66.67%, p = 0.095) or total stone-free rate (84% vs. 89.58%, p = 0.415). 5. The overall complication rate was lower in the RIRS group (10% vs. 16.67%, p = 0.331). 
CONCLUSIONS: Compared with PCNL, RIRS can reduce bleeding and overall complications, shorten the hospitalization time, and achieve satisfactory stone-free rate. As a result, RIRS can be considered an alternative treatment option for staghorn renal calculi.
Evaluating Student Satisfaction and Preferences in Higher Education Online Learning: A Post-Pandemic Exploration
Authors: Tanguihan Lucille
Published: August 2024

This study, grounded in transformational learning theories, investigated the satisfaction levels of higher education students with online learning during the COVID-19 pandemic. The study found that students expressed a neutral sentiment towards the online learning environment, with key aspects valued by students, including instructor support, guidance, and personalization. However, students reported the lowest satisfaction with the knowledge and skills acquired, indicating a need to align teaching methods with desired learning outcomes. Facility performance also received a neutral mean satisfaction score. Students appreciated webinars, seminars, and extracurricular activities, recognizing their importance in enriching online education. However, they wanted more than school-provided facilities, suggesting physical resources and service improvements. Regarding future learning modes, students preferred blended classrooms, face-to-face instruction, and specific online teaching platforms over exclusive online classes, emphasizing the need for diversified learning approaches and effective digital tools. A notable finding was the positive correlation between students' willingness to recommend online learning in the future and their overall satisfaction, underscoring the importance of instructor engagement, diverse learning modalities, and aligning teaching methods with desired learning outcomes to meet the evolving needs of students in a post-pandemic educational landscape. These findings have significant implications for the future of higher education, particularly in the design of online learning platforms and the role of educators in enhancing the student experience. Keywords: Blended Learning; Higher Education; Online Learning; Post-pandemic education; Student satisfaction.
SEZGI ORGANLARIGA ASOSLANGAN QOYISHLASH TURLARI
Authors: Nzamatdinova Dilfuza
Published: August 2024

The article examines the division of static comparisons into several lexical-thematic groups in Turkic languages, including Karakalpak, based on meanings and senses.
ХИВА ХОНЛИГИДАГИ МАДРАСАЛАР ВА УЛАРНИНГ ХОНЛИК МАДАНИЙ-МАЪНАВИЙ ҲАЁТИДА ТУТГАН ЎРНИ
Authors: Saburova Sevara , Yusupova Mazluma
Published: August 2024

The article analyzes madrasas in Khiva Khanate and their role in the cultural and spiritual life of the Khanate. The quality of education in madrasas in the Khanate was studied and their impact on the spiritual and educational environment was evaluated.
INTERVENÇÕES DE ENFERMAGEM NA GARANTIA DO BEM-ESTAR EM CUIDADOS PALIATIVOS
Authors: Cunha Bianca Morais , Júnior João Nunes Maidana
Published: August 2024

Este trabalho abordou os Cuidados Paliativos (CP) como uma abordagem fundamental para melhorar a qualidade de vida de pacientes com doenças graves e suas famílias. Exploramos a origem e o conceito dos CP, destacando sua importância no alívio do sofrimento físico, emocional, social e espiritual. A pesquisa buscou analisar a implementação dos CP no Brasil, identificando desafios e destacando a necessidade de políticas públicas mais robustas para garantir o acesso universal. A análise também abordou as responsabilidades éticas dos profissionais de saúde na prestação de cuidados paliativos. As principais considerações finais destacaram a importância dos CP, reconhecendo a falta de acesso universal e a escassez de profissionais especializados como desafios significativos. Recomendações para estudos futuros incluem pesquisas mais detalhadas sobre a implementação dos CP em diferentes regiões do Brasil e avaliação do impacto desses cuidados na qualidade de vida dos pacientes e de suas famílias. Espera-se que este trabalho contribua para uma maior conscientização sobre a importância dos CP e estimule discussões sobre como melhorar o acesso a esses cuidados essenciais.
USO DO SOFTWARE GEOGEBRA COMO FERRAMENTA PARA APLICABILIDADE DA NÚMERO DE OURO NA EEMTI PROFESSOR CLODOALDO PINTO
Authors: Landim Nilo Pinheiro , Oliveira Francisco Diego Moreira , Rocha Regina Maria Lima , Silva Osiel Gomes da , Pinheiro Ana Maria , Barbosa Alan Bruno Lopes , Araujo Adriano Melo , Souza Monique Maranbaia dos Santos , Coelho Francisco Alexandre
Published: August 2024

The motivation of this work is revealed in concern to discuss issues related to daily life and explain them in an attractive manner so that the student can absorb the information necessary for learning content more appealing as possible, thereby facilitating their learning. The objective of this work is to show the importance of the Golden Ratio to the study of geometry and number sequences in high schools, to understand how mathematicians have made to reach the golden ratio using algebraic and geometric concepts and situations that used to show whether or not the number gold, as the issue involving the Egyptian pyramids, the use of the golden ratio by Leonardo da Vinci, the relationship of this number to the Fibonacci sequence, the application in botany and so on. The methodology was used to conduct literature surveys on books and works done in this area and applying an activity involving the use of GeoGebra software and other related sequences with high school students addressing the content. Results were a little difficult in the initial handling with the software, but a high level of concentration and excitement after the transmission of the history of building the number of gold and as can be observed in nature.
Development of English Vocabulary Based on Sasak Language of Meno Mene As A Media In English
Authors: Hendi Muhamad , Herman Herman , Martini Sri
Published: August 2024

The aims of this study is to analyze the development of English vocabularies by using language of Sasak Meno Mene dialectic conducting a teaching learning process between the English teacher and the students. This study is utilized a quantitative descriptive to analyze the study. The instruments in collecting the data were employed of a questionnaire, observation, and documentation. The populations of this research are 36 students of class X that consist of 20 female and 16 male.The research was applied in Madrasah AliyahTahziulAkhlakSisik, Pringgarata, central Lombok. The results of the study shows thatthe development of word based on the sasak language can be development based on the correlation coefficient (r count), the value of r count is 0.344. This thing can happen because there is a motivation from the teacher and the researcher to the students in the classroom setting on how to the use of Sasaklanguage in comprehending of vocabularies mastery.Therefore, the English teacher may applyof using sasak language as Method in teaching English process. Because it can make the English learning process more enjoyable, fun and effective.
Pengaruh Kepemimpinan Transformasional terhadap Employee Engagement Karyawan
Authors: Kurniawan Rahmat , Wulandari Wulandari
Published: August 2024

Penelitian ini meneliti permasalahan: 1) Kurangnya kepemimpinan transformasional dilihat dari masih kurang teliti karyawan dalam menjalankan tugas terkait. 2) Employee engagement masih kurang terlihat dari kurangnya kesungguhan dalam melaksanakan tugas. 3) Kurangnya dedikasi terlihat dari keseriusan dalam menjalankan tugas terkait. Tujuan penelitian ini adalah Untuk mengetahui pengaruh positif dan signifikan kepemimpinan transformasional terhadap employee engagement pada karyawan Bandara Udara Sultan M Salahuddin Bima. Metode penelitian yang digunakan adalah kuantitatif. Dari hasil regresi linear sederhana maka diperoleh nilai constan sebesar 0,466. Hasil uji koefisien korelasi (R) sebesar 0,946. Dan uji statistik secara parsial (uji t) X didapati t-hitung>t-tabel, nilai t-hitung 24,049>t-tabel 1,66724 dan sig sebesar 0,000<0,05 berarti, h1 diterima disimpulkan bahwa terdapat pengaruh positif dan signifikan antara kepemimpinan transformasional terhadap employee engagement.
Pengaruh Pengawasan Dan Konflik Kerja Terhadap Disiplin Kerja Pegawai Pada Dinas Sosial Kota Bima
Authors: Wirdania Elis , Wulandari Wulandari , Irawan Ikbal
Published: August 2024

Permasalahan ini Kurangnya tindakan koreksi maupun pengawasan dari atasan untuk pegawainnya, Adanya pegawai yang datang terlambat pada saat apel pagi dan langsung pulang, dan ada yang tidak hadir pada saat apel pagi namun tetap datang untuk kerja, Kurangnya kewaspadaan pada tanggung jawab masing-masing pegawai, Adanya perbedaan pendapat antara pegawai yang satu dengan yang lainnya, Adanya miskomunikasi antara pegawai yang satu dengan yang lainnya. Penelitian ini yaitu bertujuan untuk mengetahui pengawasan, konflik kerja, disiplin kerja pegawai dan untuk mengetahui seberapa besar pengaruh pengawasan dan konflik kerja terhadap konflik kerja pegawai pada Dinas Sosial Kota Bima. Dalam penelitian ini metode yang digunakan adalah metode asosiatif. Dari hasil penelitian menunjukan bahwa pengawasan berpengaruh dan signifikan terhadap disiplin kerja pegawai, konflik kerja berpengaruh dan signifikan terhadap disiplin kerja pegawai, secara simultan pengawasan dan konflik kerja secara bersama sama berpengaruh signifikan terhadap disiplin kerja pegawai pada Dinas Sosial Kota Bima.
Reimagining Education?
Authors: Bjerg Petersen Karen
Published: August 2024

In this article, based on a brief introduction to the Bhutan Baccaleareaute and Nel Nodding's theories of happiness, education, and ethics of care, I will reflect on the possibilities of 'reimagining' education based on these two approaches. In conclusion, I will briefly discuss limitations and issues in the practical implementation of the two approaches to education.
Herméneutique et injustice épistémique dans la recherche en santé mentale et en éthique
Authors: Quintin Jacques
Published: August 2024

La recherche en santé mentale n’est pas à l’abri d’injustices épistémiques dans la mesure où la formulation d’hypothèses et la construction d’arguments peuvent se fonder sur un discrédit épistémologique de la narration des sujets interrogés. Il n’en va pas autrement lorsque le chercheur est éthicien et réalise une recherche en éthique. Pour surmonter cette difficulté, nous proposons une démarche herméneutique qui consiste à rendre explicites nos présupposés afin de mieux écouter et entendre ce qui s’exprime chez les participants à la recherche.
La démarche Borée
Authors: Gobeil Ariane , Riffon Olivier , Villeneuve Florence
Published: August 2024

Cet article présente une démarche structurante de mobilisation des acteurs du système alimentaire du Saguenay-Lac-Saint-Jean autour d’une vision associée à l’identité alimentaire boréale, pour en assurer un développement durable. Opérer des transformations à l’échelle d’un système alimentaire territorial présente plusieurs défis, notamment en ce qui concerne la capacité des acteurs d’entrevoir l’alimentation dans une perspective multifonctionnelle, multidimensionnelle et intersectorielle, en cohérence avec une approche systémique. C’est donc pour favoriser la transition vers un système alimentaire durable et boréal que la démarche Borée a émergé. Les partenaires du comité, en collaboration avec des chercheurs, tentent ainsi de développer les outils de dialogue et les modalités de gouvernance permettant de mobiliser l’intelligence collective et de coordonner le travail des acteurs. Cette expérience collaborative fait ressortir des mécanismes d’animation favorables à une gouvernance participative de ce système alimentaire, durable et boréal.
L’agriculture urbaine et périurbaine au Brésil
Authors: Gravel Nathalie , Lemieux Josée
Published: August 2024

Même si le Brésil a inclus l’agriculture urbaine dans son programme de lutte contre la faim, les obstacles à son déploiement, à l’entretien et à son maintien dans le temps sont encore nombreux. Plusieurs métropoles brésiliennes ont élaboré des plans d’appui à l’agriculture urbaine dans une perspective d’atteinte des objectifs de durabilité sans toutefois mettre en place des politiques publiques ayant des effets facilitateurs. Les questions auxquelles cet article tente de répondre sont : Quelle marge de manoeuvre possèdent les jardiniers urbains pour mener à bien leurs projets et influencer les politiques publiques municipales d’agriculture urbaine ? Et quel est l’avenir de l’agriculture urbaine et périurbaine (AUP) dans les métropoles brésiliennes ? Le potentiel de pérennisation de l’AUP a été étudié dans les métropoles de São Paulo, Florianópolis et Salvador de Bahia. Nous avançons que l’avenir de l’AUP au Brésil dépendra de la capacité des acteurs à négocier et élaborer des outils et politiques publiques à l’échelle municipale. Les processus de négociation de l’accès à l’espace public sur l’échiquier urbain seront analysés, ainsi que les gains réalisés dans chacune des villes, par le biais de la théorie de la régulation sociale.
Enjeux et défis de la modernisation des sites de débarquement des produits issus de la pêche maritime artisanale à Owendo (Gabon)
Authors: Bignoumba Guy-Serge , Lembe-Bekale Aline Joëlle , Bolé-Baïzoumi Sébastien
Published: August 2024

L’aménagement des pêches a pour objectif l’utilisation durable des ressources halieutiques. Il appelle notamment une intervention sur l’espace halieutique, articulé autour d’un espace de production, d’un pôle structurant et d’un espace de commercialisation. Dans cet article, nous nous intéressons aux infrastructures de pêche maritime artisanale, précisément aux sites de débarquement, qui constituent les pôles structurants de ce secteur halieutique. Nos interrogations portent sur la contribution des sites de débarquement à une gestion durable des ressources halieutiques, dans un contexte marqué par une carence en infrastructures et un sous-équipement généralisé de celles qui existent. Aussi, analysons-nous les sites de débarquement de pêche maritime artisanale d’Owendo, au Gabon, à partir des textes réglementaires, de la documentation disponible et des enquêtes de terrain fondées sur des entretiens semi-directifs avec des pêcheurs et des responsables de l’administration des pêches à Libreville. Les résultats obtenus confirment le rôle essentiel des sites de débarquement dans la durabilité des ressources halieutiques et la viabilité de la pêche maritime artisanale au Gabon, tout en appelant à leur modernisation.
Aspects discursifs et linguistiques de
la valorisation du patrimoine culturel dans le texte touristique
Authors: Markova Anna , Tchitchova Emanuela
Published: August 2024

L’article propose une analyse de la mise en scène du patrimoine
de la Vallée des rois thraces en Bulgarie dans deux
corpus de documentation touristique en langue française. L’image voulue, dégagée
de la communication nationale, et l’image perçue, observable dans la
communication étrangère, sont abordées à travers la présence quantitative et
thématique des vestiges de l’antique civilisation thrace, puis étudiées dans
leurs dimensions discursive, lexicale, terminologique, traductologique et
interculturelle en vue de la confrontation des deux démarches. La pertinence et
les effets sur le lecteur des procédés mis en œuvre par les textes traduits et
rédigés en français sont recherchés dans l’optique de l’objectif premier
d’inciter à la découverte du patrimoine en question. Les correspondances et les
divergences établies font apparaître un inventaire de techniques et d’outils
efficaces pour la construction d’un discours touristique susceptible de suggérer
l’authenticité, la charge identitaire et axiologique, la valeur esthétique et
l’offre d’altérité du patrimoine ainsi valorisé.
La dynamique épistémologique du tourisme
obscur. L’introduction du visiteur dans le patrimoine associé à la mort et à la
souffrance
Authors: Wadbled Nathanael
Published: August 2024

L’approche touristique a modifié le cadre épistémologique dans
lequel se font les recherches sur les lieux historiques associés à la mort
ou aux massacres. En mettant en avant la relation des touristes avec les
espaces visités, elle a ouvert la voie à des approches du patrimoine
centrées sur son usage plutôt que sur son intérêt intrinsèque. L’approche
touristique fait ainsi écho au tournant communicationnel de la muséologie.
Elle englobe une série de travaux, qui s’articulent et se succèdent
historiquement en se centrant de plus en plus sur la personne du visiteur.
Celui-ci apparaît alors pris dans une pratique sociale répondant à des
fonctions déterminées, est motivé pour y participer, s’y engage et fait une
expérience subjective. Expliciter ce mouvement n’est pas constater un
progrès de la recherche. Cela permet plutôt de cartographier ce champ de
façon dynamique, dans la perspective d’une histoire des idées. Cela offre
par ailleurs à chaque recherche une ressource pour déterminer sa situation
dans ce réseau, en assumant à la fois son parti pris et son positionnement
par rapport aux autres.
Digitalisation et gestion des
destinations touristiques : confrontation entre théories et réalités de
terrain
Authors: Toumia Roxane , Cloquet Isabelle
Published: August 2024

La digitalisation du secteur touristique
soulève plusieurs questionnements quant à l’adaptation aux nouvelles formes de
technologies numériques. Cet article vise à s’interroger en profondeur sur les
dimensions de gestion et de gouvernance des destinations touristiques, au regard
de la « transition digitale », réelle ou perçue, opérée dans le secteur. Alors
que la littérature scientifique en tourisme intègre davantage de questions
relatives aux nouvelles technologies, notamment en faisant référence aux
destinations dites « intelligentes » (smart tourism
destination), le présent article propose de se distancier de ces notions et
de la vision techno-centrée qu’elles induisent. À travers le cas d’étude de la
Région de Bruxelles-Capitale, en Belgique, nous étudierons comment le modèle de
gestion de la destination se modifie avec la digitalisation du secteur.
Confronter théories et réalités de terrain ont permis de saisir plus finement
les enjeux de la digitalisation pour les acteurs du système touristique
bruxellois. Ces enjeux sont loin d’être circonscrits au seul champ des
technologies, et nous verrons l’étroite relation qu’il semble y avoir entre
digitalisation et enjeux économiques, sociaux et environnementaux d’une
destination.
Formes d’éducation alternative dans la Francophonie : enjeux méthodologiques, histoire, gouvernance et réussite éducative
Authors: Brabant Christine
Published: August 2024

Ce numéro thématique porte sur l’essor de formes d’éducation alternative dans la Francophonie et sur les difficultés de les étudier. Ainsi, l’évolution de la recherche sur ce sujet n’est pas proportionnelle à son développement. Le numéro propose des thèmes représentant des enjeux importants pour l’étude de ce type d’éducation. Il aborde quatre axes : 1) les enjeux méthodologiques de ce corpus de recherche ; 2) l’histoire de ce mouvement ; 3) la gouvernance de ses différentes formes et 4) la réussite éducative des jeunes. Les auteur⋅e⋅s du numéro thématique prennent de front ces questions par six articles qui contribuent significativement au domaine sur ces axes.
Proposition d’un modèle logique du volet primaire du curriculum Montessori incluant les facteurs contextuels influant sur sa mise en oeuvre
Authors: Gaudreau Joëlle , Brabant Christine
Published: August 2024

L’engouement contemporain pour l’approche éducative instaurée par Maria Montessori est indéniable dans les réseaux professionnels et au sein de la communauté scientifique à travers le monde. Le corpus scientifique relatif aux effets de cette approche sur les apprenant⋅e⋅s est prometteur, mais encore exploratoire, sa principale limite méthodologique étant le manque d’évaluation de la fidélité de son implantation dans les milieux scolaires desquels sont tirés les échantillons. Pour contribuer à remédier à ce problème, cette étude propose un modèle logique du volet primaire (6 à 12 ans) du curriculum Montessori incluant les facteurs contextuels influant sur sa mise en oeuvre.
Pédagogie Montessori : l’autonomie de l’élève vue par les enseignant·e·s
Authors: Arapi Enkeleda
Published: August 2024

La pédagogie alternative remet en question les approches traditionnelles en matière d’enseignement et d’apprentissage. Parmi les concepts qu’on y trouve, une place importante est accordée à l’autonomie de l’élève. L’approche Montessori figure parmi ces courants de pédagogie alternative et, pour cette approche, l’autonomie constitue un pilier fondamental de l’enseignement. Cet article explore la conception et la mise en oeuvre de l’autonomie de l’élève dans le cadre de la pédagogie Montessori. Une étude de cas propose ici une présentation des représentations et des pratiques d’enseignant·e·s montessorien·ne·s au Québec.
La place du programme dans les pédagogies alternatives : trois conceptions du savoir scolaire chez les enseignants
Authors: Legavre Amélia
Published: August 2024

Les pédagogies alternatives héritent d’une réputation ambivalente quant à la place qu’elles réservent à la réussite scolaire. L’article analyse trois conceptions du savoir scolaire chez les enseignants qui s’inscrivent dans de telles pédagogies : le savoir en douceur ; le savoir pour questionner ; le savoir selon l’envie. Ces conceptions dépendent du positionnement de chaque enseignant par rapport à deux éléments : 1) la valeur accordée au savoir scolaire comparativement aux autres types de contenus ; 2) la représentation de l’enfant et du degré de contrainte jugé opportun pour son acquisition du savoir scolaire.
Flavonoid compound of red fruit papua and its derivatives against sars-cov-2 mpro: An in silico approach
Authors: Ananto Agus Dwi , Pranowo Harno Dwi , Haryadi Winarto , Prasetyo Niko
Published: August 2024

In the past years, the world has experienced a profound impact due to the abrupt appearance of a new virus (COVID-19), presenting a significant threat to human health. Currently, there exists no widely established treatment for COVID-19 that proves consistently effective, but many studies have implemented drug repurposing and the use of herbal medicines. The potential of antiviral compounds from natural products can be predicted through an in silico approach. This study aimed to determine and design flavonoid compounds from red fruits and their derivatives that have the potential to suppress the SARS-CoV-2 Mpro, ensuring a stable molecular framework and adhering to a standard pharmacokinetic profile. The study started with molecular docking using a lead compound followed by Molecular dynamics (MD) simulation up to 100 ns and pharmacokinetic prediction. The analysis of docking outcomes reveals that among flavonoid compounds, quercetin 3’-glucoside exhibits the most favourable binding energy value. Furthermore, the identification of hydrogen bonds with amino acid residues Asn142 and Cys145 provides additional rationale for selecting this compound as a pivotal candidate in the design of novel derivatives. The molecular docking procedure and subsequent MD simulations were conducted utilizing the Yasara-structure software. Furthermore, the evaluation of the pharmacokinetic profile was performed utilizing pkCSM ADMET to gain insights into the compound’s absorption, distribution, metabolism, excretion, and toxicity characteristics. According to the docking outcomes, among the 225 newly designed compounds, the ligand with code SR133 demonstrated the most favourable binding energy of −8.0950 Kcal/mol, surpassing the reference compound. Subsequent MD simulation analysis indicates that this ligand demonstrates good stability. The presence of hydrogen bonds in the active site of SARS-CoV-2Mpro involving the main amino acid residues Asn142 and Cys145 further clarifies that this new compound has excellent inhibitory potential. The pharmacokinetic prediction of SR133 shows that this compound has a good pharmacokinetic profile and is worth proposing as a new drug candidate.
Economic evaluation of fixed-dose drug combinations: A systematic review
Authors: Phung Toi Lam , Ong Due The , Ngo Nhi T. N. , Pham Trang Thuy , Nguyen Ha Thi , Duong Khanh N.C. , Dang Mai Thi Ngoc , Alcusky Matthew James , Amante Daniel J. , Nguyen Hoa L.
Published: August 2024

This study aimed to review the quality of published evidence on the cost-effectiveness of fixed-dose drug combinations (FDCs), summarize key methodologic assumptions, and make recommendations for future economic evaluations of FDCs. The search was conducted on four databases, namely Medline, Embase, Web of Science, and the International Network of Agencies for Health Technology Assessment. Studies were selected if they assessed the cost-effectiveness of FDCs compared to one or more single active ingredient dosage forms or placebo. The Consolidated Health Economic Evaluation Reporting Standards 2022 checklist was utilized for evaluating the quality of studies. The study protocol was registered in PROSPERO (CRD42021295388). A total of 39 studies were eligible for inclusion in the review. While most of the studies (n = 29) reported that FDCs are cost-effective, the comparator in the economic evaluations was not justified explicitly in most studies (n = 34). Modelling that examined cost-effectiveness did not incorporate medication adherence (n = 22), failing to consider a key advantage of FDCs. The majority of studies investigating FDCs reported that they were cost-effective interventions. However, further economic evaluations based on long-term clinical trials with larger populations are necessary. Also, future economic studies should incorporate superior treatment adherence with FDC into the model structure.
Activity-dependent lateral inhibition enables the synchronization of olfactory bulb projection neurons
Authors: Dalal Tal , Haddad Rafi
Published: August 2024

Information in the brain is represented by the activity of neuronal ensembles. These ensembles are adaptive and dynamic, formed and truncated based on the animal’s experience. One mechanism by which spatially distributed neurons form an ensemble is by synchronizing their spike times in response to a sensory event. In the olfactory bulb, odor stimulation evokes rhythmic gamma activity in spatially distributed mitral and tufted cells (MTCs). This rhythmic activity is thought to enhance the relay of odor information to the downstream olfactory targets. However, how specifically the odor-activated MTCs are synchronized is unknown. Here, we demonstrate that optogenetic activation of one set of MTCs can gamma-entrain the spiking activity of another set. This lateral synchronization was particularly effective when the recorded MTC fired at the gamma rhythm, facilitating the synchronization of only the substantially active MTCs. Furthermore, we show that lateral synchronization did not depend on the distance between the MTCs and is mediated by granule-cell layer neurons. In contrast, lateral inhibition between MTCs that reduced their firing rates was spatially restricted to adjacent MTCs and was not mediated by granule-cell layer neurons. This dissociation between these two interaction types suggests that they are mediated by different neural circuits. Our findings propose a simple yet robust mechanism by which spatially distributed neurons entrain each other spiking activity to form an ensemble.
Formation of Multinucleated Osteoclasts Depends on an Oxidized Species of Cell Surface Associated La Protein
Authors: Leikina Evgenia , Whitlock Jarred M , Melikov Kamran , Zhang Wendy , Bachmann Michael P , Chernomordik Leonid V
Published: August 2024

The bone-resorbing activity of osteoclasts plays a critical role in the life-long remodeling of our bones that is perturbed in many bone loss diseases. Multinucleated osteoclasts are formed by the fusion of precursor cells, and larger cells - generated by an increased number of cell fusion events - have higher resorptive activity. We find that osteoclast fusion and bone-resorption are promoted by reactive oxygen species (ROS) signaling and by an unconventional low molecular weight species of La protein, located at the osteoclast surface. Here, we develop the hypothesis that La’s unique regulatory role in osteoclast multinucleation and function is controlled by a ROS switch in La trafficking. Using antibodies that recognize reduced or oxidized species of La, we find that differentiating osteoclasts enrich an oxidized species of La at the cell surface, which is distinct from the reduced La species conventionally localized within cell nuclei. ROS signaling triggers the shift from reduced to oxidized La species, its dephosphorylation and delivery to the surface of osteoclasts, where La promotes multinucleation and resorptive activity. Moreover, intracellular ROS signaling in differentiating osteoclasts oxidizes critical cysteine residues in the C-terminal half of La, producing this unconventional La species that promotes osteoclast fusion. Our findings suggest that redox signaling induces changes in the location and function of La and may represent a promising target for novel skeletal therapies.
Clinical and dosimetric correlation in terms of treatment response, bladder and rectal toxicities in cervical cancer patients treated with cobalt 60 high dose rate brachytherapy
Authors: Makkapati Bharat Sai , Challapalli Srinivas , MariappanSenthiappan Athiyamaan , Kilikunnel Johan Sunny , Krishna Abhishek , Lobo Dilson , Jawahar Vaishak , Banerjee Sourjya
Published: August 2024

Background

High dose rate (HDR) image-guided brachytherapy with Cobalt-60 isotope is a relatively recent approach. The aim of the study is to evaluate the clinical and dosimetric parameters in terms of tumour response, bladder, and rectal toxicity in patients undergoing Co-60 HDR brachytherapy.

Materials and Method

All patients were initially treated with chemoradiation (CT-RT) at our center or other referral centers with external beam radiation therapy (EBRT) for a dose of 45 Gy–60 Gy at 1.8-2Gy/fraction (including nodal boost) with concomitant chemotherapy with either cisplatin or carboplatin. Patients were then scheduled for brachytherapy within 1 week after completion of CT-RT and are assessed by local examination. Depending on local examination parameters at the time of brachytherapy they were eligible either for intracavitary brachytherapy (ICBT) or interstitial brachytherapy (ISBT).

Results

The complete response (CR) observed in stage I, II, III, IVA were 60%, 79.4%, 86% and 76.2% respectively. Complete response was seen in patients with mean EQD2 of 78.67 Gy10, 83.33 Gy10, 84.23 Gy10, 85.63 Gy10 in stages I, II, III, IVA respectively. 79.2% of cisplatin-treated patients and 87.5% of carboplatin-treated patients had a complete response indicating that patients treated with either chemotherapy had similar response rates.

Conclusions

According to results obtained from the study we conclude by saying that higher rates of complete response to treatment in cervical cancer is seen in patients with shorter overall treatment time (OTT), shorter interval between end of definitive CT-RT and beginning of brachytherapy and squamous cell histology. The study also noted the trend of increasing mean EQD2 to tumor with increasing stage for achieving complete response. Higher acute bladder and rectal toxicity is seen in patients who received EQD2 of ¿70-90Gy3 and ¿70Gy3 respectively. The study findings suggest that the clinical outcomes and the toxicities are clinically comparable with other radioisotope based HDR brachytherapy treatment.
ФОТОЭЛЕКТРИЧЕСКОЕ ПРЕОБРАЗОВАНИЕ КОНЦЕНТРИРОВАННОГО СОЛНЕЧНОГО И МОЩНОГО ЛАЗЕРНОГО ИЗЛУЧЕНИЯ
Authors: Andreev V.
Published: August 2024

В статье приводятся результаты разработок гетероструктурных фотоэлектрических преобразователей (ФЭП) на основе полупроводниковых соединений А3В5, получаемых методом МОС-гидридной эпитаксии. Максимальный КПД продемонстрирован в монолитных каскадных солнечных элементах с тремя p-n переходами на основе гетероструктуры GaInP/Ga(In)As/Ge. В каскадных элементах для космических батарей КПД составляет более 30% в условиях околоземного космического пространства. Для использования в наземных условиях разработаны каскадные солнечные элементы с КПД более 43% при концентрированном солнечном излучении. Разработаны энергоустановки с системами ориентации концентраторных фотоэлектрических модулей на Солнце. Показаны перспективы крупномасштабного использования каскадных солнечных элементов в космических батареях и в наземной солнечной энергетике. Представлены результаты разработок в AlGaAs/GaAs фотоэлектрических преобразователях мощного лазерного излучения в диапазоне длин волн 800–860 нм, обеспечивающие КПД = 62% при плотностях мощности падающего лазерного излучения до 0.15 кВт/см2.
On Some Properties of Square Normal Operators
Authors: Edith Warue , Musundi Sammy W. , Ndung’u Jeremiah K.
Published: August 2024

The study of operators in Hilbert spaces is an important concept due to its wide application in areas like computer programming, financial mathematics and quantum physics. This paper focused on a class of square normal operators in a Hilbert space. Let H be a complex Hilbert space and B(H) be a bounded linear operator acting on H. Then an operator T in B(H) is a square normal if T2(T*)2 = (T*)2T2. This paper studied the commutation relations and properties of this class of operators and showed that for any square normal operator T, then T* and T-1 if it exists is square normal. Furthermore, the sum T + S and product TS of two square normal operators which commute with the adjoint of each other is square normal. To achieve this, the properties of normal operators and other operators related to normal operators were extended to square normal operators.
Öğretmenlerin 21.Yüzyıl Becerilerini Kazandırmaya Yönelik Yeterlik Algıları Ölçeğinin Geliştirilmesi: Geçerlik ve Güvenirlik Çalışması
Authors: Hızıroğlu İbrahim , Zengin Mahmut
Published: August 2024

Bu araştırmanın amacı, öğretmenlerin 21. yüzyıl becerilerini kazandırmaya yönelik yeterlik algılarını ölçebilecek geçerli ve güvenilir bir ölçme aracı geliştirmektir. Ölçek geliştirme çalışmalarında izlenen süreç takip edilerek oluşturan 65 maddelik taslak formla, Bingöl’de çeşitli okul türleri, eğitim kademeleri ve branşlarda görev yapan 698 öğretmenden veri toplanmıştır. Ölçeğin yapı geçerliliğinin belirlenmesi adına 372 öğretmenden oluşan ilk gruptan toplanan verilerle açımlayıcı faktör analizi gerçekleştirilmiştir. AFA sonucunda 40 madde ve 3 faktörden (yaşam ve kariyer becerileri, öğrenme ve yenilik becerileri, bilgi, medya ve teknoloji becerileri) oluşan toplam varyansın 45,725’ini açıklayan bir yapıya ulaşılmıştır. Elde edilen yapının doğrulanması için 326 öğretmenden oluşan ikinci bir gruptan veri toplanmış ve doğrulayıcı faktör analizi gerçekleştirilmiştir. DFA sonucunda 40 maddeden oluşan ölçeğin model-veri uyumunun doğrulandığı, ölçeğin yapı geçerlik kriterlerini sağladığı belirlenmiştir. Ölçeğin güvenirlik analizleri yapılmış ve Cronbach Alpha değeri .932, tabakalı alfa katsayısı .939, McDonald’s Omega katsayısı .934 olarak bulunmuştur. Öğretmenlerin 21. yüzyıl becerilerini kazandırmaya yönelik yeterlik algıları ölçeği, geçerlik ve güvenirlik çalışmasıyla doğrulanmış ve ölçeğin psikometrik özelliklerinin yeterli düzeyde olduğu tespit edilmiştir.