bluuebunny/crossref_metadata_2025 huggingface dataset:
Intralesional and topical treatments for Peyronie’s disease: a narrative review of current knowledge
Authors: Minore Antonio , Cacciatore Loris , Presicce Fabrizio , Iannuzzi Andrea , Testa Antonio , Raso Gianluigi , Papalia Rocco , Martini Marco , Scarpa Roberto Mario , Esperto Francesco
Published: August 2024

Peyronie’s disease (PD) presents a multifaceted challenge in contemporary urological practice, marked by penile deformity, pain, and the potential for erectile dysfunction. We meticulously explored the existing literature of intralesional/topical interventions, aiming to provide clinicians with a nuanced understanding of available options for comprehensive PD management. To conduct this review, we performed a systematic search using the PubMed, Scopus, and ScienceDirect databases, including the keywords of combination of the “Peyronie’s disease/plastic induration of the penis (PIP) and intralesional/topical treatments”. The study selection was based on adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, resulting in the inclusion of 16 articles. We delve into the effectiveness and safety profiles of collagenase Clostridium histolyticum (CCH), interferon, platelet-rich plasma (PRP), hyaluronic acid, botulinum toxin, stem cell, extracorporeal shock wave therapy (ESWT), and traction therapy, assessing their impact on penile curvature, length improvement, and patient-reported symptoms and outcomes. The best options evaluated are intralesional injections of CCH and penile traction devices, alone or in combination. Despite PD remains a challenge for urologists, the objective of this review is to contribute to the evolving landscape of PD management, fostering informed decision-making, and personalized care for individuals grappling with this challenging condition.
Evaluating the impact of Gayatri Mantra chanting and meditation on treatment outcomes in patients with chronic spontaneous urticaria: A prospective study
Authors: Samajdar Shambo Samrat , Joshi Shashank R. , Mukherjee Shatavisa , Samajdar Shinjini , Moitra Saibal , Dutta Rathindra Nath
Published: August 2024

Background:

Chronic spontaneous urticaria (CSU) is a long-lasting skin condition marked by the appearance of hives and angioedema, which significantly impacts quality of life. Despite standard pharmacotherapies, many patients remain symptomatic, necessitating the exploration of complementary treatments. This study examines the effects of integrating Gayatri Mantra (GM) chanting and meditation with conventional pharmacotherapy on CSU management.

Materials and Methods:

This study was conducted at the Diabetes and Allergy Asthma Therapeutics Specialty Clinic in Kolkata, India, this prospective observational study included 119 patients with CSU who had been on antihistamines for at least 6 months. Participants were randomized into two groups: Group A received standard pharmacotherapy, and Group B received the same pharmacotherapy along with daily GM chanting and meditation. Primary outcomes measured were the Urticaria Activity Score 7 (UAS7), Beck Anxiety Inventory (BAI), Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL), and Dermatology Life Quality Index (DLQI) assessed at baseline and after 6 months.

Results:

Both groups showed significant improvements in UAS7, CU-Q2oL, and DLQI scores posttreatment. However, Group B, which participated in GM chanting and meditation, exhibited more pronounced improvements: UAS7 scores were reduced by 49.4% compared to 41.9% in Group A; CU-Q2oL scores by 52.9% compared to 42.5%; and DLQI scores by 73.7% compared to 60.5%. The reductions in BAI scores were also significantly greater in Group B (42.3% reduction) compared to Group A (4.96%).

Conclusion:

The addition of GM chanting and meditation to standard pharmacotherapy for CSU significantly enhances the effectiveness of treatment, suggesting that this integrative approach could provide substantial benefits in the management of CSU. These findings advocate for the incorporation of spiritual and meditative practices alongside conventional medical treatments to achieve better patient outcomes.
Comparative Evaluation of the Efficacy of ProTaper & Mtwo Rotary Retreatment System and Conventional Hand H-files for Removal of Gutta-percha from Root Canal - A Stereomicroscopic Study
Authors: Chudasama Krutika D. , Chokshi Shraddha , Sanghvi Zarana , Patel Nishit , Vaidya Naman , Chhaya Deesha
Published: August 2024

Background:

Root canal retreatment aims to eliminate or substantially reduce the microbial load from the root canal and removal of previous root filling materials is the primary goal of nonsurgical retreatment.

Aim:

To comparatively evaluate the effectiveness of ProTaper retreatment files, Mtwo retreatment files, and Hedstrom files along with Gates Glidden (GG) Drill by using a stereomicroscope for the detection of remaining gutta-percha after root canal retreatment using a stereomicroscope.

Materials and Methods:

Forty-five test samples were divided into three experimental groups (15 samples each), such as Group A—ProTaper retreatment files; Group B—Mtwo retreatment files; Group C—Hedstrom files along with Gates Glidden Drill. After routine endodontic treatment in the test samples, gutta-percha was removed from the test samples as per the division of different retreatment file systems. Further, test samples were divided longitudinally and were evaluated under the stereomicroscope. Stereomicroscopic images were captured and analysed under Image Analyser Software—Image J.

Statistical Analysis:

One-way ANOVA test was used for comparison of gutta-percha removal between the groups and Tukey’s post hoc test was used for pairwise comparisons.

Results:

The least remaining filling material was seen in specimens retreated with the ProTaper universal system. The highest remaining filling material was seen in specimens retreated with Hedstrom file with Gates Glidden Drill.

Conclusion:

All experimental test techniques left gutta-percha remnants within the root canal. ProTaper universal rotary retreatment system proved to be an efficient method of removing gutta-percha and left relatively less volume in comparison with other test systems.
Oral Risk Factors in Patients with Cancer Undergoing Chemotherapy - A Pilot Study
Authors: Aradya Anupama , Kiran P. K. , Raghavendra Swamy K. N. , Doddawad Vidya G. , Ranganatha Narahari , Sravani Koduru
Published: August 2024

Background:

Treatment modalities for cancer including surgery, radiotherapy and chemotherapy, have some complications even in the oral cavity. The literature describes oral lesions that may arise as a result of chemotherapy. However, information regarding oral symptoms in advanced cancer patients is poor.

Objective:

To identify the oral manifestations like oral mucositis, dry mouth and loss of taste in patients undergoing chemotherapy treatment.

Methods:

We evaluated 60 patients affected by malignancy undergoing chemotherapy treatment. The clinical and pathological data such as age, gender, diagnosis of malignancy and types of treatments with anticancer chemotherapeutic drug treatment, were obtained. Patients were routinely evaluated for the presence of oral mucositis based on the Common Terminology Criteria for Adverse Events (CTCAE) v5.0 scale for adverse effects and graded. Other findings like dry mouth and loss of taste were recorded.

Results:

Of the 60 patients, 40 (66.6%) were male, and 20 (33.3%) females with a mean age of 53.7 years. Most patients about 63% and 83% were diagnosed with dry mouth and loss of taste, respectively and 71% of patients had mucositis. Chemotherapy drugs like Cyclophosphamide, carboplatin, nanoxel, paclitaxel, oxaliplatin, docetaxel and doxorubicin, were directly associated with oral mucositis.

Conclusion:

Patients treated with chemotherapy for cancer most often suffer from a multitude of intense and debilitating oral dysfunctions. Oral lesions found in patients undergoing chemotherapy were mucositis, dry mouth and loss of taste. These adverse effects and an appropriate symptomatic therapy need to be discussed with the patients. Chemotherapy has a significant but transient effect on the oral symptoms.
Trichofolliculoma - A Case Report
Authors: Suganya G. , Srinath Sahana , Chandrakala J , Yadav Satish T
Published: August 2024

Trichofolliculoma is a rare benign, hamartomatous adnexal tumour of the skin. Aetiology seems to be unclear. It is usually seen in adults, with no gender predilection. The most commonly involved sites are the face and scalp. It appears as a papule or nodule with small protruding hairs, which is a classic feature of the tumour. It has unique diagnostic and histopathological features that help in making a definitive diagnosis. Here, we report an exemplary case of an adult male patient aged 45 years with a gradual progressive diffuse swelling on the left side of the face for 1.5 years. Clinically, it was diagnosed as a sebaceous cyst, but after the biopsy histopathological evaluation was performed, and the diagnosis was confirmed as trichofolliculoma.
Serum Lipoprotein(a) and Angiographic Severity of Coronary Artery Disease in Asian Indians
Authors: Sandhu Arshdeep Singh , Ahmed Imran
Published: August 2024

Background:

With the renewed interest in lipoprotein a (Lp(a)) shown by the European Atherosclerosis Society in relation to cardiovascular disease occurrence worldwide and especially in the South Asian population, its estimation once in a lifetime has been recommended (1–3). However, the role of this proatherogenic Lp(a) in regulating the severity of angiographic lesions in coronary artery disease (CAD) is poorly understood. This study aimed to correlate the serum Lp(a) level with angiographic lesion severity in subjects with CAD.

Subjects and Methods:

In this cross-sectional study, a total of 100 adult patients (mean age: 52.56 [±12.84] years, 84 [84%] males) with angiographically confirmed CAD were enrolled in a tertiary care hospital in Eastern India and their serum Lp(a) levels were estimated (by immunoassay method) and correlated with the SYNTAX score groups (<22, 22–33, and >33) and extent of disease – single-vessel disease (SVD), double-vessel disease (DVD), or triple-vessel disease (TVD).

Results:

Mean serum Lp(a) was elevated in the more severe disease group with SYNTAX >33 (88.79 mg/dl) than in lesser severity disease groups of SYNTAX 22-33 (57.07 mg/dl) and SYNTAX <22 (35.13 mg/dl), and this trend was found to be significant by analysis of variance (ANOVA) (P < 0.001). Mean levels of Lp(a) were lower in patients with SVD (33.15 mg/dl) and DVD (33.93 mg/dl) than in those with the TVD group (77.71 mg/dl), and this trend was found to be significant by ANOVA (P < 0.001).

Conclusion:

Serum Lp(a) values had a high significant positive correlation with the angiographic severity (higher SYNTAX score and Multivessel CAD) in patients of CAD in this study. Lp(a) is a known risk factor for CAD in South Asians and statins do not appear to decrease their levels; further, our study compounds the problem by correlating its level with increasing severity of CAD. This study therefore asserts the importance of the estimation of Lp(a) in South Asian individuals and proposes larger studies to confirm its correlation with the severity of CAD.
Pattern of Coronary Angiography in Young Adults versus Older Adults Presented by Coronary Artery Disease in Correlation to Their Risk Factors with 1-year Follow-up of Their Clinical Outcome
Authors: El-Rabbat Khaled , Zarif Bassem , Elhafeez Mohammed Soliman Abd , Saeed Mahmoud
Published: August 2024

Background:

Coronary artery disease (CAD) is a leading cause of mortality worldwide, with varying patterns and risk factors across different age groups. While CAD is common in older adults, data on young adults are limited, with traditional risk factors and familial history playing a significant role in early disease development. The purpose of this study was to compare the coronary angiographic patterns in young adults (<40 years) and older adults (≥40 years) presented with CAD, assess the correlation with risk factors, and monitor clinical outcomes after 1 year.

Patients and Methods:

This retrospective cohort study was conducted at the National Heart Institute, including 2204 consecutive patients undergoing coronary angiography and/or percutaneous coronary intervention for CAD from January 2019 to January 2020. Patients were divided into two groups based on age: group A (<40 years) and Group B (≥40 years). Angiographic findings, risk factors, and clinical outcomes were assessed and compared.

Results:

Group B had significantly higher rates of hypertension (63.6% vs. 22.2%, P < 0.001), diabetes (53.5% vs. 24.1%, P < 0.001), and female gender (29% vs. 11.1%, P < 0.001) compared to Group A. Group A showed higher smoking rates (70.4% vs. 46.5%, P < 0.001) and positive family history (42.6% vs. 4.4%, P < 0.001). Angiographic findings revealed higher rates of single-vessel affection, coronary ectasia, aneurysm, and slow flow phenomenon in Group A, whereas Group B demonstrated more bifurcation lesions, chronic total occlusion, and calcification.

Conclusions:

This study highlights the need for age-specific approaches in managing CAD, with younger patients showing early disease onset and older patients exhibiting more complex disease. Tailored cardiovascular care is essential, focusing on lifestyle modifications in younger adults and managing metabolic conditions in older adults.
Successful Percutaneous Closure of an Undiagnosed Patent Ductus Arteriosus Causing Type 2 Endoleak
Authors: Moosavi Jamal , Sadeghipour Parham , Mohebbi Bahram , Bagheri Yaghoob , Mehdinejad Esmaeil , Jolfayi Amir Ghaffari , Sheibani Mehdi
Published: August 2024

Thoracic endovascular repair (TEVAR) is a valuable alternative to open surgical repair for aortic aneurysms, offering several benefits. However, one potential complication that demands attention is endoleak. This case report highlights a unique occurrence of type 2 endoleak, typically associated with aortic aneurysms treated by TEVAR, originating from an undiagnosed patent ductus arteriosus (PDA). The patient, a 68-year-old woman, underwent TEVAR for an aortic aneurysm complicated by underlying lung disease and pulmonary artery hypertension. During the procedure, an unexpected shunt between the aorta and the pulmonary artery was identified and subsequently revealed to be an undiagnosed PDA. Remarkably, the decision was made to continue with TEVAR while simultaneously deploying a stent graft to close the PDA. This case underscores the significance of comprehensive preprocedural aortic assessment and careful consideration of PDA closure to prevent type 2 endoleak in TEVAR, reinforcing the importance of thorough evaluation before such procedures.
Structural and stratigraphic history of the southern domain of the Indian Mountain Deformed Zone, southeastern New Brunswick, Canada: Tournaisian (Lower Carboniferous) tectonic ‘pop-up’ and collapse
Authors: Park Adrian F. , St. Peter Clint , Hinds Steven J. , Stimson Matthew R.
Published: August 2024

The southern domain of the Indian Mountain Deformed Zone (IMDZ) in southeastern New Brunswick marks a major right-lateral strike-slip fault belt active during late Tournaisian (Lower Carboniferous) sedimentation. The rocks of the Sussex Group, representing a depositional cycle from subsidence to basin inversion, occupy this zone and lie unconformable on crystalline basement, the latter representing a partially exhumed portion of the adjacent (to the south) buried Westmorland uplift. Deformation is related to early reverse faults/thrusts, later strike-slip faults. and latest normal faults. The Gorge Fault zone in the southern domain of the IMDZ demonstrates many essential features of the entire zone. The offset of The Gorge Fault zone increases to the east. In the west it forms a blind thrust and asymmetric anticline whereas in the east it expands into a reverse fault/thrust complex. A progressive evolution from reverse faults/thrusts to strike-slip fault movement resulted in a tectonic pop-up, culminating in gravitational collapse along normal faults with listric profiles that flatten out within 100–200 metres of the present erosion surface. Megabreccias formed during deposition of the Sussex Group are contemporary with reverse fault/thrusts. The geometry of the various faults is best explained by progressive deformation within an overall right-lateral strike-slip regime under general shear, with early formed features rotating both congruently and incongruently to the main IMDZ boundaries. Further complexity is a consequence of many reverse faults/thrusts and normal faults occurring close to a free surface and the latter a response to gravitational instability of the pop-up structure controlled by topography. A revised stratigraphy for the Sussex Group in the Indian Mountain Deformed Zone and its interpretation is integral to constructing the structural history. Two units, Stilesville Formation and Briggs Cross Formation, are formally defined here.
Successful Retrograde Intrarenal Surgery for a Large Kidney Stone in a Pelvic Ectopic Kidney: A Case Report and Review of Literature
Authors: Afdal Afdal , Latief Aditya Akbar , Steven Steven
Published: August 2024

An ectopic kidney is a condition in which one or both kidneys are located outside of their normal anatomical position, typically lower than  usual, and are prone to stone disease. In the past, most patients required open surgical treatment, but nowadays, laparoscopy-assisted percutaneous nephrolithotomy and multisession retrograde intrarenal surgery (RIRS) facilitate minimally invasive approaches. A 42-year- old male presented to the urology clinic with complaints of intermittent lower midabdominal pain near the suprapubic area for a year. A  computed tomography scan evaluation of the abdomen without contrast was then performed, showing incomplete staghorn with multiple calyceal stones in the ectopic kidney, with the largest stone measuring 2 × 1.2 cm and mild hydronephrosis. A single-session RIRS  was performed which successfully disintegrated the stone. This pelvic kidney, although situated within the retroperitoneum, has the  bowels positioned between the front wall of the abdomen and the kidney. The successful navigation of the flexible ureteroscope  through the deformed urinary tract made RIRS applicable in the presence of a urinary tract deformity. This case was managed with RIRS, which offers advantages in visualization and is considered a safer option compared to other methods.
Giant Bladder Calculus in a 70-year-old Female—A Case Report
Authors: Mhaske Sunil , Salpekar Radhika , Sabale Vilas , Agarwal Prabhav , Ghotankar Shambhavi
Published: August 2024

Vesical calculi are unusual in females, and giant calculi (weighing >100 g) are even more uncommon, considering the advances in  contemporary diagnostic modalities. The entity is associated with a variety of pestering symptoms—frequency, dysuria, and hematuria,  to name a few—causing serious effects on patients’ quality of life. This report cites the case of an elderly female with a giant vesical  calculus weighing 1.28 kg (12.5 cm in diameter). Our patient had no past surgical history or symptoms suggestive of bladder outlet  obstruction or neurogenic bladder. As per our literature search, a stone as large as that of our patient has not yet been found in females.  She underwent an uneventful open suprapubic cystolithotomy. A biopsy from a suspicious lesion during the surgery revealed squamous  cell carcinoma. Given that such a large stone was found in an elderly female without any predisposing causative factors, it is worthwhile  looking into the etiopathogenesis and management of giant vesical calculi.
Seventh Annual Research Meeting of the Noguchi Memorial Institute for Medical Research: Neglected Tropical Diseases
Authors: K. de Souza Dziedzom , Quaye Charles , Kwadwo Kwadwo , Joseph Joseph , Agbemelo- Tsomafo Constance , Ofori Michael , Yeboah-Manu Dorothy
Published: August 2024

Neglected Tropical Diseases (NTDs) are a group of 20 diseases associated with poverty that the World Health Organization aims to control or eliminate. Significant progress has been made in the past two decades with international commitments towards their control and elimination. NTDs in Africa, which account for 40% of the global burden, affect child development, pregnancy outcomes, and productivity. The seventh Annual Research Meeting (ARM) of the Noguchi Memorial Institute for Medical Research (NMIMR) at the University of Ghana featured numerous presentations on NTDs. These highlighted the NTD research landscape and elimination challenges, emphasising the need for government commitment and innovative financial mechanisms due to the extensive funding required. NTD research at NMIMR has informed local and global policies, contributing to capacity building by training students and health professionals. Novel tools and strategies are essential to address ongoing challenges and achieve NTD control and elimination targets.
Knowledge and Perception of Diphtheria among Residents of a Rural Community in Kaduna State, Northwest Nigeria
Authors: Babandi Z.S. , Suleiman A.G. , Darma M.A. , Indabo U.H. , Shehu S. , Hamza A.S. , Henry J. , Umar U.M. , Ojediran S.L. , Amadu L. , Ibrahim M.S. , Ejembi C.L.
Published: August 2024

Background: Diphtheria has reemerged as a public health concern in Nigeria, with outbreaks reported across several states. Catch-up  vaccination, enhanced surveillance, and risk communication were instituted to curb this. This study determined knowledge and  perception of diphtheria among members of a rural community in Kaduna State, Northwestern Nigeria.
Methods: Using a cross-sectional descriptive study design, data were collected from 590 respondents drawn through multistage  sampling. Composite knowledge and perception scores were computed and graded using median values as cut-off points for good  knowledge and perception. The data was presented using descriptive statistics, while the chi-square test of independence was used to  check for association between socio-demographic variables and outcome variables at p < 0.05.
Results: The respondents comprised 226  (38.3%) males and 364 (61.7%) females, with a mean age of 33.6 (+6.0) years. Only 117 (19.8%) respondents had ever heard of diphtheria.  Among those aware of the disease, only 28 (23.9%) identified germs as causative agents, 26 (22.2%) identified inhalation as a route of  transmission, 24 (20.5%) knew diphtheria could cause an epidemic, and 31 (26.5%) identified vaccine as a preventive measure. Most of the  respondents (81.2%) had poor knowledge and good perception (68.4%). No statistically significant relationship was observed  between sociodemographic variables and Knowledge or perception of Diphtheria.
Conclusion: While the perception of diphtheria was  good, knowledge of the disease was poor despite an ongoing outbreak. The Kaduna State government should redouble efforts in  community health education and strategic risk communication on diphtheria.
Isolation of Lactic Acid Bacteria from Camel Milk and in vitro Assessment of Their Antagonism Against Selected Foodborne Pathogenic Bacteria
Authors: Ahmed Mohamed , Mikru Abrham , Adane Million , Sileshi Henok
Published: August 2024

The use of lactic acid bacteria (LAB) as a protective culture offers a suitable alternative to chemical food pre-servatives. This study aimed to isolate LAB from raw and fermented camel milk and assess their antagonistic effects against selected bacterial pathogens (Staphylococcus aureus, Escherichia coli, and Salmonella Typhi). Twenty raw and 20 fermented camel milk samples were collected from Jigjiga, Ethiopia. Recommended microbiological protocols were followed to quantify, isolate, and identify represen-tative LAB from the samples. Moreover, the antagonistic effect of the LAB isolates was assessed using the agar-well diffusion method. A total of 112 LAB isolates were classified into three genera: Lactobacillus, Pediococcus, and Leuconostoc. Of the 112 isolates, 94 (83.9%) showed antagonism against one or more of the test pathogens, with a mean diameter of the inhibition zone (MDIZ) ranging between 16.3 and 23.5 mm. More than 21% of the LAB isolates (18 of 83) that were antagonistic to S. aureus had an MDIZ ≥22 mm. However, only four and three LAB showed an MDIZ of > 22 mm against E. coli and S. Typhi, respectively. This study allowed the isolation of LAB from camel milk, with potential biotechnological applications as a protective culture. Further taxonomic identity confirma-tion of the promising LAB isolates and their performance as in situ protective cultures for food items is envisaged.
Survey of Environmental Monitoring Practices in Fresh Produce Packinghouses
Authors: Critzer Faith , Hamilton Alexis M. , Melendez Meredith , Danyluk Michelle D. , Strawn Laura K.
Published: August 2024

Environmental Monitoring Programs (EMPs) have been historically implemented in processing facilities, with more recent application in raw agricultural commodity packing operations. EMPs verify effectiveness of sanitation programs and reduce harborage/niches of microorganisms. While benefits of EMPs are well recognized, there has not been a formal survey of produce packers adopting these programs to determine their scope, including information on sampling targets and frequency of sampling by environmental zone. Approximately 62.5% of produce packers (40/62 packinghouse; 5/10 field-pack) who responded to the survey indicated they had an EMP. ATP was the most common monitoring technique used for zone 1 surfaces, followed by generic Escherichia coli, Listeria species, and aerobic plate counts. A shift was noted towards addition and greater reliance on pathogen targets (e.g., Salmonella) for zones 2–4. While 100% of produce packers with an EMP had corrective actions (CA) identified, 42% reported never needing to implement a CA, suggesting produce packers were always in conformance. This result indicates a potential shortfall in EMP rigor, as occasional failures are expected. Overall, survey findings can be used as a baseline to assess changes in EMPs over time and to emphasize potential points of confusion when conducting outreach to the fresh produce industry.
“Reste en écho la voix” – Itzhak Katzenelson’s Dos lid fun oysgehargetn yidishn folk in Batia Baum’s French Translation
Authors: Sitarz Magdalena
Published: August 2024

This essay offers a discussion of Batia Baum’s translation of Katzenelson’s elegy into French. Opening with a presentation of the Maison de la culture yiddish – Bibliothèque Medem and Baum’s achievements as a translator from Yiddish, the article highlights the significance of the poem written in France during the German occupation and published in Paris shortly after WW2. In an illustrative analysis, challenges of the text are addressed and Baum’s choices are presented.
Dede Korkut Kitabı'nda Yeme-İçme Kültürüne İşlevsel Yaklaşım
Authors: Koçak Aynur , Mezlin Tuğba
Published: August 2024

Dede Korkut Kitabı’nda yer alan hikayelerde bireyin ve toplumun en temel ihtiyacı olan beslenme çevresinde gelişen yeme-içme kültürü bu hikâyelerin birçoğunda yer alır. Hikâyelerde Türk toplumunun kültürünü taşıma ve aktarmadaki işlevselliğini yeme-içme gelenekleri çerçevesinde görmek mümkündür. Bronislaw Malinowski’nin öncülüğünde öne çıkan işlevsel kuram, toplum içinde doğup gelişen geleneklerin farklı işlevleri olduğuna dikkat çekmektedir. Bu çalışmada Dede Korkut Kitabı’nda yer alan yiyecek ve içeceklerin, Türklerin beslenme alışkanlıkları çerçevesinde gelişen işlevlerinin yorumlanması amaçlanmış, yeme-içme gelenekleri işlevsel bir yaklaşımla değerlendirilmiştir. Öncelikle Malinowski’nin kültür tanımı ve görüşleri ele alınarak Dede Korkut anlatılarının kültürel yanı üzerinde durulmuştur. Ardından anlatılarda yer alan yiyecek ve içeceklerin toplumsal gelenekler çerçevesinde işlevselliği ele alınmıştır. Bu işlevler, yeme-içmenin fizyolojik, toplumsal, dinî-manevî, keyif verme ve sınama işlevi olarak beş ana bölümde incelenmiştir. Yeme-içmenin toplumsal işlevi kendi içerisinde misafir ağırlama gelenekleri, toy, düğün ve yağma gelenekleri, av gelenekleri olarak üç farklı başlıkta değerlendirilmiştir. Dinî-manevî işlev ise kurban ve ölü aşı kapsamında ele alınarak ardından Malinowski’nin temel ihtiyaçlar ve bunlara verilen kültürel cevaplar üzerine geliştirdiği modele göre değerlendirmeler yapılmıştır.
Komparasi Hasil Belajar Menggunakan Model Pembelajaran Problem Based Learning (PBL) dan Problem Solving (PS) Pada Materi Perubahan Lingkungan Kelas X SMA Negeri 5 Palopo
Authors: Isra Isra , Khaerati Khaerati
Published: August 2024

Komparasi Hasil Belajar Menggunakan Model Pembelajaran Problem Based Learning (PBL) dan Model Pembelajaran Problem Solving (PS) pada Materi Perubahan Lingkuan kelas X SMA Negeri 5 PalopoPenelitian ini bertujuan untuk mengetahui Komparasi Hasil Belajar Menggunakan Model Pembelajaran Problem Based Learning (PBL) dan Model Pembelajaran Problem Solving (PS) pada Materi Perubahan Lingkuan kelas X SMA Negeri 5 Palopo. Jenis penelitian yang digunakan dalam penelitian ini adalah eksperimen semu dan bentuk desainnya menggunakan two group pretest-posstest design. Instrumen yang digunakan dalam penelitian adalah tes hasil belajar dan lembar observasi keterlaksanaan model pembelajaran. Pengambilan sampel dilakukan dengan teknik purposive sampling. Hasil analisis inferensial menggunakan uji Anacova diperoleh nilai signifikansi 0,963 > 0,05, maka dapat disimpulkan bahwa H0 diterima dan H1 ditolak. Hal ini berarti tidak terdapat perbedaan hasil belajar yang signifikan antara kelas eksperimen 1 dengan menggunakan model pembelajaran Problem Based Learning (PBL) dan kelas eksperimen 2 dengan menggunakan model pembelajaran Problem Solving (PS).Kata kunci: problem based learning (pbl)-1, problem solving (ps)-2, hasil belajar-3
CHATURVINSHATI UPKRAMA AND ITS ROLE IN THE MANAGEMENT OF POISONING
Authors: Kumar Ashish , Lal Prajapati Munna , Sason Rajveer , - Akshita , Chaudhari Hinal
Published: August 2024

Agadtantra is the branch of Astanga Ayurved, having a system of knowledge for conquering poisons. Acharya
Charaka has expounded over twenty-four therapy strategies for managing poisoning. There is nothing like Chaturvinshati Upkramas for handling toxins. The majority of them are founded on the same current medical theory.
Chaturvinshati Upkramas are typical of all varieties of Visha, including Sthavara, Jangama, Gara, Dooshi Visha,
etc. Generally, the doctor should choose Upakramas based on Visha Prakruti (constitution), Saatmya (compatibility), Ritu (season), Desha (location), Vega (impulse), and Bala-Abala (patient's strength and weakness combined
with the poison).
El malestar psicológico durante el Covid-19 en la UAEM
Authors: Betanzos Díaz Norma , Paz Rodríguez Francisco , Pérez Mayo Augusto Renato , Roque Nieto Nohemí
Published: August 2024

El Sars-cov-2 (Covid-19), generó preocupación mundial durante el 2019 y con ello se presentó secuelas psicológicas en la población. En Morelos las cosas no fueron diferentes, por ello se invitó a participar en una encuesta en línea, a una muestra de estudiantes y trabajadores de la UAEM. Se incluyeron las escalas de ansiedad, personalidad tipo-D, resiliencia, desmoralización y autocompasión, para conocer el malestar psicológico percibido durante la cuarentena. De los 379 encuestados, el 45.5% se clasificó con personalidad tipo D, un 14.5% presentó ansiedad severa, el 24.8% moderada, el 35.5% leve y un 22.7% ansiedad mínima. Se observó que la personalidad tipo d y la ansiedad se relacionan con resiliencia (rs= -.433; p= 0.001, rs= -.231; p= 0.001) y desmoralización (rs= .660; p= 0.001, rs= .627; p= 0.001). También con la escala de autocompasión, en el dominio sobre-identificación (rs= -.567; p= 0.001, rs= -.542; p= 0.001), aislamiento (rs= -.574; p= 0.001, rs= -.521; p= 0.001), y auto-juicio (rs= -.567; p= 0.001, rs= -.542; p= 0.001). Las relaciones encontradas nos muestra que el malestar psicológico durante la pandemia de Covid-19 fue alto, y que puede estar mediado por el tipo de personalidad, la resiliencia, desmoralización y la autocompasión de la persona ante este evento.
Autoestima social y académica como predictores del rendimiento académico en estudiantes universitarios
Authors: Hernández-Valles Jonathan Hermayn , González-Vázquez Annel , Candia Arredondo Josefina Sarai , Tizoc Márquez Arodi
Published: August 2024

La autoestima de las personas puede verse influenciada por los cambios acelerados que se viven a nivel mundial, estos eventos y desarrollos globales pueden tener un impacto significativo en la percepción que una persona tiene de sí misma y en su bienestar emocional. Los estudiantes con baja autoestima pueden sentirse incapaces de llevar a cabo las tareas académicas y objetivos planteados por el docente en clase, lo que puede afectar su rendimiento académico. Además, la autoestima actúa en la forma en que los estudiantes se relacionan con sus compañeros, lo que puede orientarse a dificultades para establecer relaciones saludables. El presente capítulo plantea como propósito identificar el efecto de la autoestima social y académica sobre el rendimiento académico, además de responder a objetivos específicos como identificar la autoestima social y académica de acuerdo con el género y la ocupación, es decir, si el estudiante trabajaba o no. Respecto a la metodología, se trató de un diseño descriptivo correlacional predictivo, con un muestreo aleatorio simple, se conformó por una muestra de 201 estudiantes universitarios de una institución pública de Monterrey, Nuevo León, México. De acuerdo con el propósito del estudio, se reportó relación positiva y significativa entre autoestima académica y el rendimiento académico; la autoestima social presenta efecto negativo con el rendimiento académico.
El cotidiano de mujeres adultas con dolor muscular y articular crónico y sus repercusiones
Authors: López Miguez Aimée Rosalinda , Fernández Sánchez Abigail , Rodríguez Leana Claudia
Published: August 2024

El dolor muscular y articular es un problema de salud pública en la población en general, afecta desde las actividades cotidianas personales, así como laborales, este problema lleva a las personas a disminuir su calidad de vida por el deterioro y por la cronicidad que limita la movilidad requiriendo a corto plazo aditamentos para moverse, por lo consiguiente son altos los costos, así como la diversidad de tratamientos que en algunos momentos no funcionan y complica el estado de salud de la persona. La principal causa de discapacidad a nivel mundial puede afectar las articulaciones con presencia de dolor regional o generalizado y enfermedades inflamatorias, entre ellas los trastornos del tejido conectivo o la vasculitis, entre otras. Por este motivo el objetivo de la investigación fue caracterizar las experiencias de la vida cotidiana de las mujeres que padecen dolor muscular y articular crónico y sus repercusiones.
Konvensi Tradisi Garap Seni Dugjring Sebagai Dasar Penciptaan Karya Seni Lokal
Authors: Wihendar Wihendar
Published: August 2024

Penelitian ini membahas tentang pola tabuh seni dugjring yang mempunyai nilai konvensi tradisi yang kuat ketika dilihat dari pola tabuh dan bentuk pertunjukannya bersifat helaran yang dijadikan landasan dasar proses penciptaan karya. Dalam penelitian metode yang digunakan yakni metode Kualitatif yakni etnografi karena menyangkut suatu wilayah dan observasi auditif karena bersangkutan dengan aspek musikal dan pengalaman empiris. Pandangan masyarakat banyak aturan-aturan yang harus difahami dan ditanamkan meskipun aturan tersebut tidak tertulis. Oleh sebab itu, konvensi tradisi ini sangat penting untuk difahami. Tujuan dari artikel yakni untuk memperkenalkan konvensi tradisi pola tabuh seni dugjring yang memiliki nilai dan karakter diwujudkan menjadi karya Nyanyian Kunti. Sehingga perlunya pelestarian dan pengenalan terhadap khalayak muda untuk tetap melestarikannya
COMPARING STUDENTS’ ATTITUDE TOWARD CODE-SWITCHING
Authors: Villaabrille Irene Joyce , Generalao Sharmine , Mametes Queenie , Bacatan Jovenil
Published: August 2024

This study aimed to determine the significant difference in students’ attitudes toward code-switching when analyzed according to age, gender, and ethnicity. The study employed the non-experimental quantitative research design utilizing the descriptive-comparative method and stratified random sampling with Mean, t-test, and Analysis of Variance (ANOVA) as statistical tools. Researchers used adapted and validated survey questionnaires in gathering the data from the 200 target respondents. The result showed that the affective indicator of the student’s attitude generated a high mean score and showed that the items were often manifested. This means that students’ positive attitude toward code-switching is often manifested, implying that students use code-switching frequently and have a positive outlook on it. It was also found that the students’ demographic profiles do not have a significant difference in their attitude toward code-switching. Even the results show no significant difference; these results still emphasize the importance of integrating code-switching into educational practices, acknowledging its potential benefits in enhancing linguistic flexibility and fostering communication strategies in academic settings. Researchers emphasize performing more research regarding code-switching that is not included in the current study and explore different approaches to deepen understanding of the reasons behind their attitude by providing plausible factors and elaborations.
 

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Examination of Middle School Students' Digital Literacy Levels
Authors: Aydoğdu Özgür Utkucan , Faiz Melike
Published: August 2024

The development of digital literacy equips students with the skills to effectively utilize technology and helps them become informed and responsible individuals in the digital world. Effective instruction in digital literacy empowers students with the necessary skills to navigate and utilize technology proficiently, thereby fostering their ability to engage critically and responsibly in the digital environment. The inaugural objective of this research is to assess the proficiency in digital literacy among middle school students. During epidemics and crises, when education is delivered digitally, it is important to assess students' levels of digital literacy. Within this framework, an effort has been undertaken to ascertain whether variables such as gender, the quantity of siblings, maternal education, and the frequency of internet connectivity exert any influence on the digital literacy aptitude of middle school students. The study adopts a quantitative research design, employing a descriptive survey model for data collection. The study population, comprising 268 middle school students in Kastamonu, was determined through an appropriate sampling technique. Subsequently, the gathered data underwent analysis via a quantitative data analysis program, and the results were subjected to interpretation. The findings reveal that the digital literacy levels of middle school students surpass the average across all dimensions. Moreover, there is a negative correlation between the number of siblings and digital literacy levels, indicating a decrease as the sibling count increases.
Structural modeling of E-NTPDase-substrate complexes preserving catalytic experimental features
Authors:   , Moraes João Victor Badaró de
Published: August 2024

The Ecto-Nucleoside Triphosphate Diphosphohydrolase (E-NTPDase or NTPDase) family, essential for converting tri- and diphosphate nucleotides to monophosphates, significantly influences purinergic/pyrimidinergic signaling. However, detailed structural insights, particularly for NTPDase-nucleotide complexes, are scarce. The limited structural information leads to challenges in rationally optimizing and exploring the therapeutic potential of these enzymes. Addressing this limitation, this study introduces a computational strategy for assembling NTPDase-substrate complexes. While Molecular Docking may serve this purpose, limitations such as the inability to precisely reproduce experimentally characterized ligand conformations can undermine the complexes' reliability and further computational studies relying on them. Leveraging the active site's high conservation across NTPDases, we hypothesized a consistent substrate binding conformation. Pursuing that, we structurally aligned the available experimental structures in substrate-bound productive states and identified a canonical substrate conformation prevalent in the majority of experimentally resolved complexes. We also observed other general features of the complexes, which were conserved in all the characterized experimental structures. In light of these conserved features, we proposed a method for modeling NTPDase-nucleotide complexes that are compliant with the available experimental data. These complexes can be modeled by transferring crystallized substrate structures to well-modeled NTPDase structures, also carrying their cofactors and relevant water molecules. Subsequent energy minimization and equilibration through Molecular Dynamics simulations yield a final structure that closely resembles the conserved features characterized in experimental structures. We demonstrated this approach's utility by modeling complexes for each human NTPDase with ATP, ADP, GTP, GDP, UTP, and UDP, presenting a novel methodological avenue for future research. Keywords: E-NTPDase; Computational Modeling; Enzyme-Substrate Complex.
O uso do pronome feminino enquanto marca identitária de um grupo gay de Belém do Pará
Authors: Maciel Suely Claudia Lobato , Kailer Dircel Aparecida
Published: August 2024

Pesquisas sociolinguísticas de Terceira Onda (Eckert, 2005) no Brasil ainda são relativamente recentes. Alguns autores passaram a se debruçar sobre a variação linguística enquanto marca identitária de sujeitos/agentes dentro de comunidades de prática. Nessa perspectiva, o presente estudo investiga a variação no uso de ele/ela por homens cis autodeclarados gays. Durante a observação participativa realizada na ONG Arte pela Vida, percebemos que os sujeitos participantes dessa comunidade usam, dentro da própria comunidade, variavelmente ele/ela para se referirem aos seus pares, ou seja, outros homens cis autodeclarados gays. Essa variação chamou nossa atenção e, por isso, foi escolhida como objeto de análise para este trabalho. Alguns estudos (Mendes, 2012; Santana, 2018; Ribeiro, 2021), que embasam teoricamente esta pesquisa, apresentam a importância da relação entre gênero e linguagem, especialmente no que diz respeito à variação linguística e à construção de identidades homossexuais. Após nossa análise, observamos que a utilização de ela para designar pessoas cis do sexo masculino acontece: a) quando há somente voluntários da ONG; b) quando as reuniões são informais; e c) entre pessoas pertencentes ao mesmo grupo anteriormente identificado neste texto. Observou-se, também, que seu emprego não é usual por pessoas que não sejam identificadas da mesma forma.
Analisis Sistem Pendingin Mesin Bantu Generator Menggunakan Media Air Laut
Authors: Sya'bani Ahmad , Lesmana I Gede Eka
Published: August 2024

The generator converts mechanical power into electrical power because the wire coil inside cuts the magnetic force, causing a voltage and generating an electric current through a cable connected to a sliding ring as the connecting terminal for the current to discharge. Because the high temperatur of the cooling system is caused by dirty tubes in the Fresh Water Cooler and leaking seawater pipes leading to the seawater pump. For this reason, the generator cooling system must always be maintained routinely so that it does not experience problems, especially when the generator engine is started with a temperatur of not more than 85° C. Generator cooling system maintenance. The subject that is the focus of this research is the selection of data sources for analysis of the causes of high coolant temperaturs in diesel generator motors aboard the MT.TY. The results of the research The temperatur calculations were carried out from 14 to 20 June 2023 that the efficiency of the generator was positive at 7.69% which was good from 14 June 2023 08-12 until 17 June 2023 16-20. This shows that the generator is working well and needs to be stabilized, as well as a positive water cooling efficiency of 13.54%. This shows that with a water debit of 3 L/m it functions properly and does not need maintenance, and the decrease in seawater cooling pressure entering the Water Fresh Water Cooler can be caused by a dirty filter or a drop in pump pressure, which can increase the engine cooling water temperatur. master on board.
Evaluasi Sistem Pengendalian Internal atas Pembelian Persediaan di Retail CV Kurnia
Authors: Sari Kumala Linda , Widajantie Tituk Diah
Published: August 2024

The research was carried out with the aim of finding out and evaluating the internal control system for purchasing inventory which is useful for creating effective goods management in accordance with company objectives and avoiding damage and other things that are detrimental to CV Kurnia. The method used in conducting research is a qualitative method with data analysis techniques, a qualitative descriptive analysis method by analyzing data obtained from CV Kurnia. Analysis was carried out on the internal control system for purchasing inventory and the implementation of internal control for purchasing inventory by evaluating whether the internal control of the purchasing system at CV Kurnia was running in accordance with existing theory and comparing it. CV Kurnia has problems in the process of receiving goods and distributing employee duties. Based on the results of data collection within the company, it can be seen that the biggest problem is that there are sections that have the same job desk and it is felt that they need to split members. It can be seen that there are also obstacles in other sections that require new functions to help the process of receiving goods so that the process is responsible and Validation of goods arriving according to procedures. The final result of the research carried out is that it is necessary to separate members into sections that have the same job desk so that performance can be more effective, it is also necessary to establish a new function to assist in the process of receiving goods so that responsibility and validation of incoming goods can be controlled.
Humas dalam Perspektif Manajemen Pendidikan Islam
Authors: Rizal Saifur
Published: August 2024

Public Relations atau yang dalam bahasa Indonesia dikenal dengan istilah hubungan masyarakat dan disingkat dengan PR memiliki peran penting dalam meningkatkan mutu yang mengarah pada kemajuan suatu institusi begitu pula dengan lembaga pendidikan. Pemahaman tentang PR seringkali dikaitkan dengan teori-teori Barat terlepas dari nilai-nilai yang terkandung di dalamnya. padahal dalam Islam semua teori yang memberikan pemahaman tentang hubungan masyarakat sudah jelas, bahkan Al-Qur'an secara komprehensif telah memberikan pedoman yang sifatnya universal dan dinamis. Selain itu, Hadis sebagai sumber hukum kedua setelah Al-Qur'an juga menunjukkan nilai-nilai keteladanan yang menjadi pegangan dalam melakukan hubungan masyarakat. Prinsip, aturan, dan etika yang terkandung di dalam keduanya tentang hubungan masyarakat akan memberikan nilai lebih, sehingga pemahaman teori Barat yang berkembang dan berakar dapat digantikan. Apalagi dalam sebuah lembaga pendidikan Islam, setidaknya dalam mengimplementasikan konsep hubungan masyarakat berpegangteguh pada prinsip-prinsip yang ada dalam al-qur’an dan hadits nabi muhammad SAW agar apa yang menjadi tujuan bersama bisa tercapai.