bluuebunny/crossref_metadata_2025 huggingface dataset:
Prawno-polityczne aspekty wyboru przewodniczącego Komisji Europejskiej w latach 2004-2019
Authors: Piotrowski Mirosław
Published: December 2022

Stanowisko przewodniczącego Komisji Europejskiej było i pozostaje jednym z najważniejszych w strukturze obsadzanych funkcji w całej Unii Europejskiej. Z formalno-prawnego punktu widzenia szef KE plasuje się po przewodniczącym Rady Europejskiej. Jednakże z uwagi na praktyczne prerogatywy przyznawane mu w traktatach, często traktowany bywa jako osoba pierwsza, czyli najważniejsza. Stąd wyborom przewodniczącego Komisji z reguły towarzyszyły emocje polityczne. W latach 2004-2019 doszło do największego rozszerzenia Wspólnot Europejskich, ale także do odrzucenia oraz przyjęcia nowych, podstawowych aktów prawnych. Jakkolwiek umieszczone w nich przepisy określające tryb wyboru przewodniczącego KE, którego kompetencje poszerzano, w zasadzie nie ulegały większym modyfikacjom, to zdecydowanie zmieniała się ich prawna interpretacja. Główną osią sporu było przejmowanie przez Parlament Europejski prerogatywy, desygnowania kandydata na szefa KE, dotychczas przynależnej Radzie Europejskiej.
Effectiveness of robot-assisted arm therapy in stroke rehabilitation: An overview of systematic reviews
Authors: Straudi Sofia ,   Working group upper limb “CICERONE” Italian Consensus Conference on Robotic in Neurorehabilitation, Baluardo Ludovica , Arienti Chiara , Bozzolan Michela , Lazzarini Stefano G. , Agostini Michela , Aprile Irene , Paci Matteo , Casanova Emanuela , Marino Dario , La Rosa Giuseppe , Bressi Federica , Sterzi Silvia , Giansanti Daniele , Perrero Luca , Battistini Alberto , Miccinilli Sandra , Filoni Serena , Sicari Monica , Petrozzino Salvatore , Solaro Claudio Marcello , Gargano Stefano , Benanti Paolo , Boldrini Paolo , Bonaiuti Donatella , Castelli Enrico , Draicchio Francesco , Falabella Vincenzo , Galeri Silvia , Gimigliano Francesca , Grigioni Mauro , Mazzoleni Stefano , Mazzon Stefano , Molteni Franco , Petrarca Maurizio , Picelli Alessandro , Posteraro Federico , Senatore Michele , Turchetti Giuseppe , Morone Giovanni
Published: December 2022

BACKGROUND: Robot-assisted arm therapy (RAT) has been used mainly in stroke rehabilitation in the last 20 years with rising expectations and growing evidence summarized in systematic reviews (SRs). OBJECTIVE: The aim of this study is to provide an overview of SRs about the effectiveness, within the ICF domains, and safety of RAT in the rehabilitation of adult with stroke compared to other treatments. METHODS: The search strategy was conducted using search strings adapted explicitly for each database. A screening base on title and abstract was realized to find all the potentially relevant studies. The methodological quality of the included SRs was assessed using AMSTAR-2. A pre-determined standardized form was used to realize the data extraction. RESULTS: 18 SRs were included in this overview. Generally, positive effects from the RAT were found for motor function and muscle strength, whereas there is no agreement for muscle tone effects. No effect was found for pain, and only a SR reported the positive impact of RAT in daily living activity. CONCLUSION: RAT can be considered a valuable option to increase motor function and muscle strength after stroke. However, the poor quality of most of the included SRs could limit the certainty around the results.
Ki Hadjar Dewantara Thought on Character Education in The Perspective of Islamic Education
Authors: Bustomi Ahmad , Zuhairi Zuhairi , Basyar Syaripudin
Published: December 2022

This Research aims to describe the thoughts of Ki Hadjar Dewantara on character education in the perspective of Islamic education. This Research is called library research. The data taken in this research consist of primary data and secondary data. The method of data processing uses the analytical descriptive method after the data is collected, classified, compared, interpreted, and finally given the conclusion. The conclusion is made using deductive and inductive patterns. The result of this research shows that character education according to Ki Hadjar Dewantara is the guidance of character in the life of children growing. Character education can be formed through education, experience, life test, sacrifice, and environmental impact. Hereafter the internalized values become an intrinsic value underlying attitude and behavior then repeatedly until becomes a habit, and the habit is guided and maintained then be a character. The method of character education through among method namely momong, among and "ngemong" mean habituation, example, and teaching. Meanwhile, the steps are childhood, the development of souls and thoughts, and the formation of character or social awareness.
Political Philosophy of Illumination: An Analysis of Political Dimensions in Suhrawardi's Thought
Authors: Reza Adeputra Tohis
Published: December 2022

Suhrawardi is a renowned philosopher famous for his thoughts on the philosophy of Illumination. His thoughts are contained in his mangnum opus, The Wisdom  of Al-Isryq (Hikmat Al-Isryq). This study aims to reveal the prominent aspect of various political dimensions in his work, whose primordial focus was on the aspects of the political system and the concept of power. The political system and the concept of power were then characterized as a political philosophy of Illumination. For this reason, this study not only uses a qualitative method with factual historical study techniques regarding figures but also uses an analytical approach to the theory of sociology of knowledge by Peter L. Berger and Thomas Lucmann and the theory of socio-political philosophy of al-Farabi's emanation. The sociology of knowledge is used to analyze the social dimensions involved in the formation of Suhrawardi's thoughts. Meanwhile, the socio-political philosophy of emanation is used to characterize the system and the concept of political power contained in the Wisdom of al-Isryq. The study concludes that the political system contained in the Illumination philosophy is divine, theocratic, and based on the concept of power in the form of self-control. Keywords: Hikmat al-Isryq, Illumination Political Philosophy, Suhrawardi, Reality, Sociology of Knowledge
Los principios del derecho de familia: Actas del IV Congreso de Derecho de Familia de la Universidad Autónoma de Chile
Authors: Ibáñez Meza Nicolás , Navarro Marañón Andrea , León Silva Glorimar , Cury Pastene Patricio , Arce Ramírez Daniela , Sepúlveda Varela Jorge , Escobar Zarzar Leyla , Medina Sánchez Karla , Carrillo Suárez Fernanda , Soto Cid Matías , Ocampo Naveas Natalia
Published: December 2022

El libro Los principios del derecho de familia busca aportar explicaciones sobre aspectos atingentes a principios jurídicos basales del derecho de familia, tanto en la judicatura, como en la litigación y en la academia. Basado en dos ejes temáticos, se exponen trabajos sobre el principio de interés superior del niño y luego, principios sobre parentalidad en el contexto de conflictos familiares y cuestiones asociadas a los progenitores. La obra reúne siete artículos de carácter científico elaborados por académicos, académicas y profesionales de distintas regiones de Chile y también países vecinos, los que buscan dar explicaciones dogmáticas a conflictos frecuentes del área del derecho de familia.
Pengaruh Kompetensi Kerja, Budaya Kerja, Dan Motivasi Terhadap Kinerja Petugas Puskeswan Pada Dinas Peternakan Dan Kesehatan Hewan Kabupaten Tulungagung
Authors: Sumariyani Tutus , Arisyahidin Arisyahidin
Published: December 2022

Employees as the source of the way for the organization, enable the functioning of an organization and become the most important element in management. Therefore, the role of humans is very important in achieving the goals of an organization. This study aims to: (1) analyze the variables of competence, work culture, and work motivation have a simultaneous effect on the performance of the Puskeswan Officers, (2) analyze the competence variables partially influence the performance of the Puskeswan officers, (3) analyze the variables of work culture that have a partial effect on Partial to the Performance of Puskeswan Officers, (4) Analyzing work motivation variables that partially affect the Performance of Officers' Employees, (5) Analyzing which variables of competence, work culture, and work motivation have the dominant influence on the Performance of Puskeswan Officers. This study uses quantitative analysis methods, namely the analysis of data that has been scored according to a predetermined measurement scale using statistical formulas. The analysis used on data in the form of numbers. While the data analysis method used: (1) descriptive statistical analysis, (2) classical assumption test, and (3) inferential statistical analysis. The results showed that: (1) Competence, Work Culture and Motivation had a significant influence on the performance of Puskesmas Officers at the Department of Animal Husbandry and Animal Health, Tulungagung Regency. (2) Competence has a significant influence on the performance of Puskesmas officers at the Department of Animal Husbandry and Animal Health, Tulungagung Regency. (3) Work culture has a significant effect on the performance of Puskesmas officers at the Department of Animal Husbandry and Animal Health, Tulungagung Regency. (4) Motivation has a significant effect on the performance of Puskesmas Officers at the Department of Animal Husbandry and Animal Health, Tulungagung Regency. (5) Motivation has the most dominant influence on the Performance of Health Center Officers at the Livestock and Animal Health Service of Tulungagung Regency.
KONSEP MOTIVASI BELAJAR DI MASA PANDEMI COVID 19
Authors: Hikmiyah Siti Nafsiatul , Burhanuddin Hamam
Published: December 2022

The Covid 19 pandemic has changed the education system in Indonesia, especially in the learning process, changes in the learning process will be an impact on the learning patterns as running face-to-face, also on student learning motivation. this research discribe the concept of learning motivation during the Covid 19 pandemic, using a literature review approach, which contains theories relevant to research problems, based on the available literature, especially from articles published in various scientific journals. The data collection using primary sources and secondary sources, analysis using content analysis techniques. As the results, the concept of learning motivation during the Covid 19 pandemic divided into two factors,  students have high motivation due to student intelligence factors, student activity, the development of student learning independence, the existence of discipline, and learning is a fun activity. Low student motivation to learn is caused by low intelligence factors, excessive demands, weak discipline, stress, and learning is a tedious activity.
POLA KEPEMIMPINAN KIYAI DALAM MENGEMBANGKAN PENDIDIKAN BERBASIS KARAKTER DI PONDOK PESANTREN AL MUNAWWIR KRAPYAK YOGYAKARTA
Authors: Amanah Isti Lailatul , Ahmad Fandi , Jannah Nur , Wardani Tedi
Published: December 2022

The globalization era is developing at this time demands the existence of national cadres who have the quality of human resources as a whole, tough in facing all the challenges of the times. This can be realized in the support of a quality education system. Among Muslims themselves, Islamic boarding schools are referred to as examples of educational institutions that have advantages, both from the aspect of scientific tradition and morality. Islamic boarding schools are considered capable of instilling the character values of education in children so that the nation's cadres have full human resources. The research method that the author uses in this study is using qualitative research with a location in PP Al Munawwir Krapyak Yogyakarta, the results of this study are the leadership style applied by the Al Munawwir Krapyak Islamic boarding school, namely the democratic system, deliberation for consensus and also an authoritarian system. And in developing students' character education, namely by providing advice, habituation, exemplary (uswatun Hashanah), giving rewards and punishments to students.
STATE AND WAR: HISTORICAL AND PHILOSOPHICAL INTERRACTION REFLECTION
Authors:   Academy of the State Penitentiary Service, Chernihiv, Ukraine, Donii N.Ye.
Published: December 2022

Defining a person as “Zoon politikon”, Aristotle actually indicated the factor of existence and survival of humanity: a person must be and function in a social group – that is the state, and, accordingly, it must look for relatively acceptable options for his interaction within various situations. However, despite such an unwritten law, humanity unleashes and engages in wars continuously. Based on this fact, the determination of war and the initiation of active participation in it by certain groups of people, as well as the legitimacy of their actions, is reproduced in public opinion and social practice throughout the history of mankind and is a useful basis for considering views on the relationship between the state and war. The purpose of the article is to present a concise analysis of the opinions of the wise men of the past on the essence of the relationship between the state and war. From the ancient Greek philosopher Heraclitus, we can trace the idea that war, as the most characteristic manifestation of “fight” in its dialectical sense, is the driving force of the development of history and the state, a means of knowledge, a law of existence. The majority of liberals express the opinion that war creates and conditions law, especially positive law, which is the result of the activity of the state and power, therefore, through war, states are also created, and therefore, no nation has developed without war (M. Revon). It is noted that war, on the one hand, is welcome and necessary for the state, on the other, it kills the state and brings disaster, no matter what “scientific tools” are used to conduct it. It is concluded that war as one of the politics means is a function of the state and a conflict of interests, primarily due to the essence of state power itself in all its manifestations. War is support for the existence and content of the state. Key words: war, state, classical concept of war, malignant war, power of the state.
COMPARATIVE ANALYSIS OF THE CONCEPTS OF «JUSTICE» AND «ADMINISTRATIVE PROCEDURE» IN TERMS OF TRYING CASES ON ADMINISTRATIVE OFFENSES
Authors:   Academy of the State Penitentiary Service, Chernihiv, Ukraine, Kravchuk M.V.
Published: December 2022

The article provides the comparison of the powers of the court and other public administration authorities in trying cases on administrative offenses. The attitude of some leading researchers who study the issues of administrative law and procedure to the concepts of «procedure» and «process» is demonstrated. The legislative ability to differentiate these concepts in the course of administrative proceedings and the position of the court of cassation in this matter are analysed. It is emphasized that practicing judges are insensitive to the issue of delimitation of rules of procedure and rules of process because of unimportance of delimitation for the fulfilment of tasks of the legal proceedings. It is summarized that the procedure is an integral part of the judicial proceeding, but the Code of Ukraine on Administrative Offenses does not contain the rules of process. It is noted that the dichotomy of the nature of administrative offenses has led to trying administrative cases under the rules of criminal and administrative proceedings, including courts of different jurisdictions. The results of the study provided the grounds for the author to outline the fundamental difference between justice and administrative procedure through the category of equity. The author notes in the conclusions that the scope of authority sufficient to perform the task of proceedings in this category of cases is decisive for the formation of a range of subjects of law among public authorities regardless of the truth of any of the statements about the relationship between the concepts of «administrative process» and «administrative procedure». Accordingly, the issues of reassessment of this task in terms of protection of human rights and fundamental freedoms, as well as in terms of the criminal nature of some administrative offenses (full compliance with the law or the achievement of equality) require further research. Key words: equality, judicial proceedings, administrative offences, administrative tort relations, public administration authorities.
PRACTICE OF USING THE ASSESSMENT OF THE RISK OF COMMITTING A REPEATED CRIMINAL OFFENSE BY CONVICTS SENTENCED TO IMPRISONMENT
Authors:   Institute of Advanced Training of Personnel of the State Criminal and Executive Service of Ukraine of the Academy of the State Penitentiary Service,  Chernihiv, Ukraine, Klochko I.M.
Published: December 2022

Assessing the risks of committing a repeated criminal offense is the process and result of analyzing the impact of risk factors on the probability of the criminal behavior of the convict, its possible consequences, determination of criminogenic needs and measures in order to minimize them. During 2021, according to the information of the State Criminal and Executive Service of Ukraine, 53750 assessments of the risk of committing a repeated criminal offense by those sentenced to imprisonment were entered into the “CASANDRA” subsystem: the first – 34681, the intermediate – 15527, and the final – 3543. During the period from 2021 till 2022, 340 heads of social and psychological service departments of social, educational and psychological service departments of penal institutions and pretrial detention centers were trained in the Territorially Separated Department “Bila Tserkva Branch of the Academy of the State Penitentiary Service”. The results of the survey during the training of heads of departments on the practical application of risk assessment in penal institutions and the comparative analysis of the tool allow us to single out certain aspects of the application of risk assessment and identify gaps in the legislation. The experience of practical use of the new tool is at an initial stage, so there are many questions and points about filling out the risk assessment. This article defines the specifics of the use and application of the risk assessment of repeated criminal offenses by those sentenced to imprisonment (hereinafter referred to as risk assessment) by employees of the departments of social, educational and psychological work with convicts in penal institutions. The legislation regulating the issue of risk assessment has been studied. Key words: assessment of the risk of committing repeated criminal offenses, criminogenic needs, static risk factors, dynamic risk factors.
An overview of the history of media education in Canada
Authors: Tsvietkova Hanna , Beskorsa Olena , Pryimenko Liudmyla
Published: December 2022

The article's primary objective is to provide the first comprehensive retrospective examination of Canadian media education history. The authors support the periodization, identify the trends, the periodization criteria, and the three main periods of establishment and development of Canadian media education in the context of socio-political and sociopedagogical determinants based on the theoretical findings of Canadian media educators. The historical foundations for Canada's development of media education are made clear. According to pedagogical theory and practice, the core of media education is the study of theory and the development of practical skills for mastering contemporary mass media. This knowledge is seen as belonging to a distinct, independent field of knowledge. The authors conclude that media education is connected to all forms of media, including the collection of information and communication tools that each person uses on a daily basis: printed media (newspapers, magazines), auditory media (radio, audio), and screen media (movies, television, video, multimedia, the Internet, etc.); they also define the fundamental elements of media education and conclude that it is a subset of media literacy and media culture. The article describes the evolution of media education associations, approaches, and programs. It has been proven necessary to use positive Canadian experience to address issues with implementing media education in Ukraine in order to improve and humanize that country's educational system in the framework of studying the experience of Canadian media theorists and practitioners.
Supporting a person-centred approach in clinical guidelines. A position paper of the Allied Health Community – Guidelines International Network (G-I-N)
Authors: van Dulmen Simone A. , Lukersmith Sue , Muxlow Josephine , Santa Mina Elaine , der Sanden Maria W. G. Nijhuis-van , J. van der Wees Philip
Published: December 2022

Background A person-centred approach in the context of health services delivery implies a biopsychosocial model focusing on all factors that influence the person’s health and functioning. Those wishing to monitor change should consider this perspective when they develop and use guidelines to stimulate active consideration of the person’s needs, preferences and participation in goal setting, intervention selection and the use of appropriate outcome measures. 

Objective To develop a position paper that promotes a personcentred approach in guideline development and implementation. 

Design, setting and participants We used three narrative discussion formats to collect data for achieving consensus: a nominal group technique for the Allied Health Steering Group, an Internet discussion board and a workshop at the annual G-I-N conference. We analysed the data for relevant themes to draft recommendations. 

Results We built the position paper on the values of the biopsychosocial model. Four key themes for enhancing a person-centred approach in clinical guidelines emerged: (i) use a joint definition of health-related quality of life as an essential component of intervention goals, (ii) incorporate the International Classification of Functioning, Disability and Health (ICF) as a framework for considering all domains related to health, (iii) adopt a shared decision-making method, and (iv) incorporate patient-reported health outcome measures. The position statement includes 14 recommendations for guideline developers, implementers and users. 
Review of coating cracking and barrier integrity on paperboard substrates
Authors: PANEK JOEL , HART PETER W.
Published: December 2022

Barrier packaging formats are major growth areas for the pulp and paper industry. It is technically challenging to maintain barrier properties during converting and end-use applications. Improved manufacturing capabilities and coating formulation knowledge will help maintain barrier integrity and enable growth of barrier products in challenging applications. These improvements will accelerate product development and commercialization, and allow faster response to product performance issues such as cracking. The literature on coating cracking provides knowledge mostly on the effects of coating formulations and to a lesser extent on substrate effects. Despite a large number of publications dedicated to coating failures, the approach to improve coating cracking remains empirical, and the transferability between studies and to real life applications has not been well established. Model development that successfully predicts commercial performance is in its infancy. However, some of these simplified models do a fairly good job predicting experimental data. The current work reviews the state of understanding as regards coating and barrier cracking and highlights the need for more research on cracking and barrier integrity.
THE RESPONSIBILITY FOR ENVIRONMENTAL DAMAGES DURING ARMED CONFLICTS: THE CASE OF THE WAR BETWEEN RUSSIA AND UKRAINE
Authors: Albakjaji Mohamad
Published: December 2022

Background: There is no war without catastrophic impacts, not only on humans and states but also on the environment and nature. As with all wars, the question is raised as to whether an invasion or aggression is legitimate according to international law. This research aims to discuss an emerging issue at the international level, which is the responsibility of the aggressor state for the environmental damages incurred by the victim state. This paper discusses the possibility of establishing Russia’s responsibility for the environmental damages incurred in Ukraine. It will also shed light on the possible ways Ukraine may raise Russia’s responsibility, internationally speaking. The novelty of this study stems from its originality – it is the first on this topic in the field of international relations and international law.
Methods: In this research, the author used a case study to provide an in-depth perspective on the responsibility of the invading state for the environmental damages caused to the victim state. Here, the author used a historical and statistical framework to shed light on the impacts of the Russian aggression against Ukraine on the environment. Moreover, analytical and structural methods were deployed to explain the methods by which Ukraine and the international community might establish Russian responsibility for the environmental damages caused by the invasion. To support the ideas discussed in this paper, the author uses legal texts, international conventions, and official reports issued from national and international institutions.
Results and Conclusions: The author found that the Russian aggression against the Ukrainian territory has caused severe environmental damages, which cannot go unpunished. Although traditional international law may be insufficient to punish Russia, customary law, warfare law, and international environmental law include rules that may be used to raise the Russian responsibility for these damages.
MEDIATION IN POST-WAR RESTORATION IN UKRAINE
Authors: Romanadze Luiza
Published: December 2022

Background: This article addresses the challenges of developing mediation in Ukraine, the lack of effective coordination between courts and mediators, and issues of low awareness in Ukrainian society about mediation. It is argued that Ukrainian courts and mediation in Ukraine are going concurrent ways so that mediation is not integrated into or reinforcing the court-based litigation system. Meanwhile, the national mediation community must mature through the organization of high-quality interaction with the judicial system. Moreover, the war and post-war period will cause a new workload of civil and commercial disputes that are generally suitable for mediation, especially when the disputants residing in different regions after fleeing from war. This article is aimed at finding sustainable and fast solutions for raising awareness of mediation in Ukrainian society and effective coordination between courts and mediators based on the progress already achieved.
Methodology: This article used doctrinal legal research to evaluate the options of cooperation between courts and mediation, empirical analysis to examine judicial system performance and the mediation community status quo, analyse options for closer cooperation of courts and mediators, and find sustainable solutions for promoting mediation.
Results and Conclusions: Courts and the mediation community must work together to break the general reliance on traditional litigation; courts should actively promote mediation through sustainable means, and the mediation community should improve the quality control of mediation services, develop a complaint-handling procedure, and further progress with online platforms for choosing a mediator.
THE RECOVERY OF UKRAINE IN THE FIELD OF JUSTICE: CHALLENGES AND PRIORITY GOALS
Authors: Stefanchuk Maryna
Published: December 2022

Background: Currently in Ukraine, a significant objective is to promote the construction of a peaceable and open society, ensuring access to justice for all. Such a system must be effective, accountable, and based on the broad participation of institutions at all levels. This article highlights some of the priority steps in the recovery of the justice system in Ukraine. Special attention is given to the priority goals and problematic aspects of the functioning of the institutions of the national justice system, given the declared aim of forming a sustainable justice system. Current challenges in the field of national justice, priority goals and appropriate measures for their achievement have all been analysed.
Methods: To achieve the goals of the research, general and special scientific research methods were applied, such as comparative-legal and semantic-structural methods and the method of grouping, analysis, synthesis, and generalisation.
Results and Conclusions: It has been established that the first priority goal of ensuring proper functioning of the judiciary is structural modernisation and optimisation of judicial authorities, including a comprehensive audit of the powers of bodies and institutions of the justice system in order to eliminate duplication of functions and ensure procedures for the effective use of resources.
The following were substantiated as risks for achieving such a goal: controversial recognition of the impossibility of the state to be solely responsible for the duration of processes for updating the authorised composition of judicial governance bodies; proposals for the transformation of the system of professional training and professional development of judges; the lack of objective justification for the determination of judicial jurisdiction for the consideration of certain categories of cases; and proposals for recognising the long-term consideration in the parliament of the Draft Law on abolition of the Bar monopoly.
Current trends in the development of functions of advocacy in Ukraine have been highlighted, including selective and inconsistent implementation of bar monopoly on representation of another person in court; restriction of the rights of the Bar self-government bodies in the field of forming judicial corps, extension of the state's control powers advocacy; and the search for an optimal model of governance of the advocacy profession. The key challenges of the prosecutor's office, and priority goals and measures for their achievement, have been highlighted. The possible risks of further reform of this institution due to the disputed constitutionality of its personnel, which were reset as a result of previous priority reform measures, have been emphasised, which may call into question the legitimacy of the new staff of the prosecutor's office and does not allow the assertion of the final completion of these processes.
Eksperimen Pelat Beton Bertulang Bambu Ampel
Authors: Rohimah Rima Siti , Walujodjati Eko
Published: December 2022

Kebutuhan Indonesia akan jalan dan akses gedung semakin meningkat, tetapi tidak diimbangi dengan pertumbuhan ekonomi yang seimbang. Oleh karena itu, dicari suatu alternatif yang berbiaya rendah untuk membuat strukturnya kuat dan ringan. Sebagai alternatif untuk pelat beton bertulang baja, komponen non struktural, dan sebagainya, pelat beton bertulang bambu ampel merupakan kombinasi yang efektif. Bambu ampel yang akan digunakan merupakan bambu dengan umur lebih dari satu tahun, kemudian bambu ini akan dibentuk menyerupai tulangan besi polos dengan diameter 8 mm. Selanjutnya dilaksanakan pengujian dengan umur perawatan 28 hari. Penelitian ini bertujuan untuk mengetahui pengaruh bambu haur terhadap kelayakan beton ditinjau dari kekuatan lentur satu arah dan kuat tarik bambu ampel itu sendiri. Penelitian ini dilakukan menggunakan metode eksperimen dan dibuat benda uji sebanyak tiga buah untuk pengujian kuat lentur satu arah dengan dimensi benda uji (10x20x60) cm. Dari hasil penelitian dapat disimpulkan rata-rata besar kuat tarik pada bambu ampel adalah 396,10 MPa dan memenuhi standar tulangan besi polos yaitu minimal kuat tarik sebesar 350 MPa dan kapasitas kuat lentur pelat beton yang didapat dengan mengganti tulangan besi menggunakan bambu ampel adalah 1,16  KNm.
Analysis of Vessel Density Using OCTA in Nonarteritic Anterior Ischemic Optic Neuropathy
Authors: Lee Soo Jung , Kim Sook Young , Lee Dong Hun
Published: December 2022

Purpose: To investigate the intraocular vessel density in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA).Methods: Medical records of patients with NAION were retrospectively analyzed. Their age, sex, best corrected visual acuity, color vision results, mean deviation of visual field test were analyzed. Using results of OCT and OCTA that was performed at first visit within 3 weeks of symptom onset, vessel densities in eyes with NAION were evaluated by comparing contralateral unaffected eyes. Furthermore, in only affected eyes, the correlation between visual acuity at the time of diagnosis and anatomical factors such as mean vessel density and retinal nerve fiber layer (RNFL) thickness was investigated.Results: Twenty-five patients (11 males and 14 females) were enrolled in this study and the mean age was 65.92 ± 9.37 years. Whole RNFL thickness in affected eye was significantly lower than that in unaffected eye (p < 0.001). The average peripapillary vessel density was also significantly lower in affected eyes, 45.63% ± 7.60% compared to that in the contralateral eyes, 51.44% ± 3.40% (p = 0.004). In analysis of only 25 affected eyes, there was no significant correlation between each sectoral peripapillary RNFL thickness and vessel density. There was also no significant correlation between the visual acuity and the vessel density and retinal nerve fiber layer thickness in the ischemic peripapillary hemisphere. However, there was a significant negative correlation between the visual acuity and the un-ischemic peripapillary hemisphere with a coefficient of -0.608 (p = 0.001).Conclusions: The higher vessel density of nonaffected sector, the better visual acuity at the time of diagnosis in patients with NAION. Patency of blood supply in the preserved peripapillary intraretinal vessel density sector may affect the visual function.
LAMA MENDERITA DENGAN KUALITAS HIDUP PASIEN PPOK
Authors: Hasaini Asni
Published: December 2022

Background: The number of COPD cases is estimated to be ranked third as the most common cause of death in middle-income countries. The most dominant symptom is shortness so that it can affect social activities that negatively impact the quality of life. Quality of life can decrease with the severity and duration of the patient's diagnosis. Objective: To analyze the relationship between duration of suffering and the quality of life of COPD patients at Ratu Zalecha Martapura. Method: This type of quantitative correlation study with a cross-sectional approach with a sample of 104 COPD patients in Ratu Zalecha Martapura Regional Hospital using Consecutive Sampling. Research instruments using questionnaires and for quality of life using the Saint George Respiratory Questionnaire Chronic Obstructive Pulmonary Disease (SGRQ-COPD) and data analysis using Spearman Rho. Results: There is a relationship between the duration of suffering and the quality of life of COPD patients at Ratu Zalecha Martapura with a value of ρ value = 0.002 and rho value = 0.294. Conclusion: The length of time suffered by the majority of COPD patients in the old category ≥ 3 years by 59.6%, the quality of life of the majority of COPD patients in the poor category by 75%. There is a relationship between the duration of suffering and the quality of life of COPD patients in Ratu Zalecha Martapura with a value of ρ value = 0.002 (ρ value <0.05) and rho value = 0.294.
Latar Belakang: Jumlah kasus PPOK diperkirakan menjadi peringkat ketiga sebagai penyebab kematian tersering di negara berpenghasilan menengah. Gejala yang paling dominan adalah sesak sehingga dapat mempengaruhi aktivitas sosial yg berdampak negative terhadap kualitas hidup. Kualitas hidup dapat menurun sejalan dengan tingkat keparahan dan lama pasien didiagnosis penyakit. Tujuan: Untuk menganalisis hubungan antara Lama menderita dan Kualitas Hidup Pasien PPOK di Ratu Zalecha Martapura. Metode: Jenis Penelitian kuantitatif korelasi dengan pendekatan cross sectional dengan sampel penelitian sebanyak 104 pasien PPOK di RSUD Ratu Zalecha Martapura dengan menggunakan Consecutive Sampling. Instrumen penelitian menggunakan kuesioner dan untuk kualitas hidup menggunakan Saint George Respiratory Questionnare Chronic Obstructive Pulmonary Disease (SGRQ-COPD) dan analisis data menggunakan  Spearmans Rho. Hasil: Ada hubungan antara Lama menderita dan Kualitas Hidup Pasien PPOK di Ratu Zalecha Martapura dengan nilai ρ value = 0,002 dan nilai rho = 0,294. Kesimpulan: Lama Menderita Pasien PPOK mayoritas dalam kategori lama ≥ 3 tahun) sebesar 59,6%, Kualitas Hidup Pasien PPOK mayoritas  dalam kategori buruk sebesar 75%. Ada hubungan antara Lama menderita dan Kualitas Hidup Pasien PPOK di Ratu Zalecha Martapura dengan nilai ρ value = 0,002 (ρ value <0,05) dan nilai rho = 0,294.
Advances of deep learning in electrical impedance tomography image reconstruction
Authors: Zhang Tao , Tian Xiang , Liu XueChao , Ye JianAn , Fu Feng , Shi XueTao , Liu RuiGang , Xu CanHua
Published: December 2022

Electrical impedance tomography (EIT) has been widely used in biomedical research because of its advantages of real-time imaging and nature of being non-invasive and radiation-free. Additionally, it can reconstruct the distribution or changes in electrical properties in the sensing area. Recently, with the significant advancements in the use of deep learning in intelligent medical imaging, EIT image reconstruction based on deep learning has received considerable attention. This study introduces the basic principles of EIT and summarizes the application progress of deep learning in EIT image reconstruction with regards to three aspects: a single network reconstruction, deep learning combined with traditional algorithm reconstruction, and multiple network hybrid reconstruction. In future, optimizing the datasets may be the main challenge in applying deep learning for EIT image reconstruction. Adopting a better network structure, focusing on the joint reconstruction of EIT and traditional algorithms, and using multimodal deep learning-based EIT may be the solution to existing problems. In general, deep learning offers a fresh approach for improving the performance of EIT image reconstruction and could be the foundation for building an intelligent integrated EIT diagnostic system in the future.
Calcium phosphate-based nanomedicine mediated CRISPR/Cas9 delivery for prostate cancer therapy
Authors: Wei Chao-Gang , Zhang Rui , Wei Lan-Yi , Pan Peng , Zu He , Liu Ya-Zhen , Wang Yong , Shen Jun-Kang
Published: December 2022

Introduction: Erythropoietin producing hepatocyte receptor A2 (EphA2) is widely presented in the tumor cells, closely related to tumor cell migration, not cell apoptosis and proliferation. Based on its high expression in castration-resistant prostate cancer (CRPC), we herein develop a CRISPR-Cas9-based genome-editing nanomedicine to target erythropoietin producing hepatocyte receptor A2 for the treatment of castration-resistant prostate cancer.

Methods: To this end, TAT was designed to stabilize the distribution of calcium, and then bound to ribonucleoprotein (RNP) to form nanoparticles RNP@CaP-TAT.

Results: This nanoparticle has a simple synthesis process with good biocompatible, to achieve the knockout of tumor cells (PC-3) targeting erythropoietin producing hepatocyte receptor A2 gene and to effectively suppress the migration of tumor cells.

Discussion: This delivery genome editing system provides a promising gene therapy strategy for the treatment of castration-resistant prostate cancer, showing good potential against castration-resistant prostate cancer tumor metastasis. In addition, it can be extended to other types of cancer with highly heterogeneous gene expression.
Recent advances in electronic skins: material progress and applications
Authors: Cao Hua-Li , Cai Sui-Qing
Published: December 2022

Electronic skins are currently in huge demand for health monitoring platforms and personalized medicine applications. To ensure safe monitoring for long-term periods, high-performance electronic skins that are softly interfaced with biological tissues are required. Stretchability, self-healing behavior, and biocompatibility of the materials will ensure the future application of electronic skins in biomedical engineering. This mini-review highlights recent advances in mechanically active materials and structural designs for electronic skins, which have been used successfully in these contexts. Firstly, the structural and biomechanical characteristics of biological skins are described and compared with those of artificial electronic skins. Thereafter, a wide variety of processing techniques for stretchable materials are reviewed, including geometric engineering and acquiring intrinsic stretchability. Then, different types of self-healing materials and their applications in electronic skins are critically assessed and compared. Finally, the mini-review is concluded with a discussion on remaining challenges and future opportunities for materials and biomedical research.
Engineered cell culture microenvironments for mechanobiology studies of brain neural cells
Authors: Castillo Ransanz Lucía , Van Altena Pieter F. J. , Heine Vivi M. , Accardo Angelo
Published: December 2022

The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain development and neural functioning. Stiffness, viscoelasticity and spatial organization of brain tissue modulate proliferation, migration, differentiation, and cell function. However, the mechanical aspects of the neural microenvironment are largely ignored in current cell culture systems. Considering the high promises of human induced pluripotent stem cell- (iPSC-) based models for disease modelling and new treatment development, and in light of the physiological relevance of neuromechanobiological features, applications of in vitro engineered neuronal microenvironments should be explored thoroughly to develop more representative in vitro brain models. In this context, recently developed biomaterials in combination with micro- and nanofabrication techniques 1) allow investigating how mechanical properties affect neural cell development and functioning; 2) enable optimal cell microenvironment engineering strategies to advance neural cell models; and 3) provide a quantitative tool to assess changes in the neuromechanobiological properties of the brain microenvironment induced by pathology. In this review, we discuss the biological and engineering aspects involved in studying neuromechanobiology within scaffold-free and scaffold-based 2D and 3D iPSC-based brain models and approaches employing primary lineages (neural/glial), cell lines and other stem cells. Finally, we discuss future experimental directions of engineered microenvironments in neuroscience.
Making sense of fragmentation and merging in lineage tracing experiments
Authors: Dang Yiteng , Rulands Steffen
Published: December 2022

Lineage tracing experiments give dynamic information on the functional behaviour of dividing cells. These experiments therefore have become an important tool for studying stem and progenitor cell fate behavior in vivo. When cell proliferation is high or the frequency of induced clones cannot be precisely controlled, the merging and fragmentation of clones renders the retrospective interpretation of clonal fate data highly ambiguous, potentially leading to unguarded interpretations about lineage relationships and fate behaviour. Here, we discuss and generalize statistical strategies to detect, resolve and make use of clonal fragmentation and merging. We first explain how to detect the rates of clonal fragmentation and merging using simple statistical estimates. We then discuss ways to restore the clonal provenance of labelled cells algorithmically and statistically and elaborate on how the process of clonal fragmentation can indirectly inform about cell fate. We generalize and extend results from the context of their original publication.
The role of mitochondria-associated membranes mediated ROS on NLRP3 inflammasome in cardiovascular diseases
Authors: Zhao Jiahao , Li Junli , Li Guoyong , Chen Mao
Published: December 2022

Reactive oxygen species (ROS) metabolism is essential for the homeostasis of cells. Appropriate production of ROS is an important signaling molecule, but excessive ROS production can damage cells. ROS and ROS-associated proteins can act as damage associated molecular pattern molecules (DAMPs) to activate the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in cardiovascular diseases. Previous studies have shown that there are connected sites, termed mitochondria-associated membranes (MAMs), between mitochondria and the endoplasmic reticulum. In cardiovascular disease progression, MAMs play multiple roles, the most important of which is the ability to mediate ROS generation, which further activates the NLPR3 inflammasome, exacerbating the progression of disease. In this review, the following topics will be covered: 1. Molecular structures on MAMs that can mediate ROS generation; 2. Specific mechanisms of molecule-mediated ROS generation and the molecules' roles in cardiovascular disease, 3. The effects of MAMs-mediated ROS on the NLRP3 inflammasome in cardiovascular disease. The purpose of this review is to provide a basis for subsequent clinical treatment development.
Development and implementation of a nurse-based remote patient monitoring program for ambulatory disease management
Authors: Coffey Jordan D. , Christopherson Laura A. , Williams Ryan D. , Gathje Shelby R. , Bell Sarah J. , Pahl Dominick F. , Manka Lukas , Blegen R. Nicole , Maniaci Michael J. , Ommen Steve R. , Haddad Tufia C.
Published: December 2022

Introduction

Numerous factors are intersecting in healthcare resulting in an increased focus on new tools and methods for managing care in patients' homes. Remote patient monitoring (RPM) is an option to provide care at home and maintain a connection between patients and providers to address ongoing medical issues.

Methods

Mayo Clinic developed a nurse-led RPM program for disease and post-procedural management to improve patient experience, clinical outcomes, and reduce health care utilization by more directly engaging patients in their health care. Enrolled patients are sent a technology package that includes a digital tablet and peripheral devices for the collection of symptoms and vital signs. The data are transmitted from to a hub integrated within the electronic health record. Care team members coordinate patient needs, respond to vital sign alerts, and utilize the data to inform and provide individualized patient assessment, patient education, medication management, goal setting, and clinical care planning.

Results

Since its inception, the RPM program has supported nearly 22,000 patients across 17 programs. Patients who engaged in the COVID-19 RPM program experienced a significantly lower rate of 30-day, all-cause hospitalization (13.7% vs. 18.0%, P = 0.01), prolonged hospitalization >7 days (3.5% vs. 6.7%, P = 0.001), intensive care unit (ICU) admission (2.3% vs. 4.2%, P = 0.01), and mortality (0.5% vs. 1.7%, P = 0.01) when compared with those enrolled and unengaged with the technology. Patients with chronic conditions who were monitored with RPM upon hospital discharge were significantly less likely to experience 30-day readmissions (18.2% vs. 23.7%, P = 0.03) compared with those unmonitored. Ninety-five percent of patients strongly agreed or agreed they were likely to recommend RPM to a friend or family member.

Conclusions

The Mayo Clinic RPM program has generated positive clinical outcomes and is satisfying for patients. As technology advances, there are greater opportunities to enhance this clinical care model and it should be extended and expanded to support patients across a broader spectrum of needs. This report can serve as a framework for health care organizations to implement and enhance their RPM programs in addition to identifying areas for further evolution and exploration in developing RPM programs of the future.