bluuebunny/crossref_metadata_2025 huggingface dataset:
Mucosal Adhesive Chitosan Nanogel Formulations of Antibiotics and Adjuvants (Terpenoids, Flavonoids, etc.) and Their Potential for the Treatment of Infectious Diseases of the Gastrointestinal Tract
Authors: Zlotnikov Igor D. , Belogurova Natalya G. , Poddubnaya Irina V. , Kudryashova Elena V.
Published: September 2023

Bacterial infections are usually found in the stomach and the first part of the small intestine in association with various pathologies, including ulcers, inflammatory diseases, and sometimes cancer. Treatment options may include combinations of antibiotics with proton pump inhibitors and anti-inflammatory drugs. However, all of them have high systemic exposure and, hence, unfavorable side effects, whereas their exposure in stomach mucus, the predominant location of the bacteria, is limited. Chitosan and nanogels based on chitosan presumably are not absorbed from the gastrointestinal tract and are known to adhere to the mucus. Therefore, they can serve as a basis for the local delivery of antibacterial drugs, increasing their exposure at the predominant location of therapeutic targets, thus improving the risk/benefit ratio. We have used E. coli ATCC 25922 (as a screening model of pathogenic bacteria) and Lactobacilli (as a model of a normal microbiome) to study the antibacterial activity of antibacterial drugs entrapped in a chitosan nanogel. Classical antibiotics were studied in a monotherapeutic regimen as well as in combination with individual terpenoids and flavonoids as adjuvants. It has been shown that levofloxacin (LF) in combination with zephirol demonstrate synergistic effects against E. coli (cell viability decreased by about 50%) and, surprisingly, a much weaker effect against Lactobacilli. A number of other combinations of antibiotic + adjuvant were also shown to be effective. Using FTIR and UV spectroscopy, it has been confirmed that chitosan nanogels with the drug are well adsorbed on the mucosal model, providing prolonged release at the target location. Using an ABTS assay, the antioxidant properties of flavonoids and other drugs are shown, which are potentially necessary to minimize the harmful effects of toxins and radicals produced by pathogens. In vivo experiments (on sturgeon fish) showed the effective action of antibacterial formulations developed based on LF in chitosan nanogels for up to 11 days. Thus, chitosan nanogels loaded with a combination of drugs and adjuvants can be considered as a new strategy for the treatment of infectious diseases of the gastrointestinal tract.
Inhalable Combination Powder Formulations for Treating Latent and Multidrug-Resistant Tuberculosis: Formulation and In Vitro Characterization
Authors: Eedara Basanth Babu , Fan Claire , Sinha Shubhra , Khadka Prakash , Das Shyamal C.
Published: September 2023

Tuberculosis (TB) is an infectious disease resulting in millions of deaths annually worldwide. TB treatment is challenging due to a huge number of global latent infections and due to multidrug-resistant forms of TB. Inhaled administration of anti-TB drugs using dry powder inhalers has various advantages over oral administration due to its direct drug delivery and minimization of systemic side effects. Pretomanid (PA-824, PA) is a relatively new drug with potent activity against both active and latent forms of Mycobacterium tuberculosis (Mtb). It is also known for its synergistic effects in combination with pyrazinamide (PYR) and moxifloxacin (MOX). Fixed-dose combination powder formulations of either PYR and PA or PYR and MOX were prepared for inhaled delivery to the deep lung regions where the Mtb habitats were located. Powder formulations were prepared by spray drying using L-leucine as the aerosolization enhancer and were characterized by their particle size, morphology and solid-state properties. In vitro aerosolization behaviour was studied using a Next Generation Impactor, and stability was assessed after storage at room temperature and 30% relative humidity for three months. Spray drying with L-leucine resulted in spherical dimpled particles, 1.9 and 2.4 µm in size for PYR-PA and PYR-MOX combinations, respectively. The powder formulations had an emitted dose of >83% and a fine particle fraction of >65%. PA and MOX showed better stability in the combination powders compared to PYR. Combination powder formulations with high aerosolization efficiency for direct delivery to the lungs were developed in this study for use in the treatment of latent and multidrug-resistant TB infections.
Camellia sinensis (L.) Kuntze Extract Attenuates Ovalbumin-Induced Allergic Asthma by Regulating Airway Inflammation and Mucus Hypersecretion
Authors: Kang Sohi , Kim Hyun-Yong , Lee A Yeong , Kim Hyo Seon , Park Jun Hong , Moon Byeong Cheol , Nam Hyeon Hwa , Chae Sung-Wook , Jung Bokyung , Moon Changjong , Shin In Sik , Kim Joong Sun , Seo Yun-Soo
Published: September 2023

Asthma is a pulmonary disease induced by the inhalation of aeroallergens and subsequent inappropriate immune responses. Camellia sinensis (L.) Kuntze has been evaluated as an effective antioxidant supplement produced from bioactive compounds, including flavonoids. In this study, we aimed to determine the effects of Camellia sinensis (L.) Kuntze extract (CE) on ovalbumin-induced allergic asthma. The components of CE were analyzed using high-performance liquid chromatography (HPLC) chromatogram patterns, and asthmatic animal models were induced via ovalbumin treatment. The antioxidant and anti-inflammatory effects of CE were evaluated using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), and nitric oxide (NO) assays. Seven compounds were detected in the CE chromatogram. In the ovalbumin-induced mouse model, CE treatment significantly decreased the inflammation index in the lung tissue. CE also significantly decreased eosinophilia and the production of inflammatory cytokines and OVA-specific IgE in animals with asthma. Collectively, our results indicate that CE has anti-inflammatory and antioxidant activities, and that CE treatment suppresses asthmatic progression, including mucin accumulation, inflammation, and OVA-specific IgE production.
Personalized and Precision Medicine in Asthma and Eosinophilic Esophagitis: The Role of T2 Target Therapy
Authors: Bagnasco Diego , Savarino Edoardo Vincenzo , Yacoub Mona-Rita , Braido Fulvio , Candeliere Maria Giulia , Giannini Edoardo , Passalacqua Giovanni , Marabotto Elisa
Published: September 2023

The role of type 2 inflammation has been progressively associated with many diseases, including severe asthma, atopic dermatitis, nasal polyposis, eosinophilic granulomatosis with polyangiitis, and, recently, eosinophilic esophagitis. Despite this, the association between asthma and esophagitis is still poorly known, and this is probably because of the low prevalence of each disease and the even lower association between them. Nonetheless, observations in clinical trials and, subsequently, in real life, have allowed researchers to observe how drugs acting on type 2 inflammation, initially developed and marketed for severe asthma, could be effective also in treating eosinophilic esophagitis. For this reason, clinical trials specifically designed for the use of drugs targeted to type 2 inflammation were also developed for eosinophilic esophagitis. The results of clinical trials are presently promising and envisage the use of biologicals that are also likely to be employed in the field of gastroenterology in the near future. This review focuses on the use of biologicals for type 2 inflammation in cases of combined severe asthma and eosinophilic esophagitis.
Hydroxypropyl Methylcellulose Bioadhesive Hydrogels for Topical Application and Sustained Drug Release: The Effect of Polyvinylpyrrolidone on the Physicomechanical Properties of Hydrogel
Authors: Pan Patrick , Svirskis Darren , Waterhouse Geoffrey I. N. , Wu Zimei
Published: September 2023

Hydrogels are homogeneous three-dimensional polymeric networks capable of holding large amounts of water and are widely used in topical formulations. Herein, the physicomechanical, rheological, bioadhesive, and drug-release properties of hydrogels containing hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) were examined, and the intermolecular interactions between the polymers were explored. A three-level factorial design was used to form HPMC–PVP binary hydrogels. The physicomechanical properties of the binary hydrogels alongside the homopolymeric HPMC hydrogels were characterized using a texture analyzer. Rheological properties of the gels were studied using a cone and plate rheometer. The bioadhesiveness of selected binary hydrogels was tested on porcine skin. Hydrophilic benzophenone-4 was loaded into both homopolymeric and binary gels, and drug-release profiles were investigated over 24 h at 33 °C. Fourier transform infrared spectroscopy (FTIR) was used to understand the inter-molecular drug–gel interactions. Factorial design analysis supported the dominant role of the HPMC in determining the gel properties, rather than the PVP, with the effect of both polymer concentrations being non-linear. The addition of PVP to the HPMC gels improved adhesiveness without significantly affecting other properties such as hardness, shear-thinning feature, and viscosity, thereby improving bioadhesiveness for sustained skin retention without negatively impacting cosmetic acceptability or ease of use. The release of benzophenone-4 in the HPMC hydrogels followed zero-order kinetics, with benzophenone-4 release being significantly retarded by the presence of PVP, likely due to intermolecular interactions between the drug and the PVP polymer, as confirmed by the FTIR. The HPMC–PVP binary hydrogels demonstrate strong bioadhesiveness resulting from the addition of PVP with desirable shear-thinning properties that allow the formulation to have extended skin-retention times. The developed HPMC–PVP binary hydrogel is a promising sustained-release platform for topical drug delivery.
Millisecond-Response Nematic Liquid Crystal for Augmented Reality Displays
Authors: Tang Jiaxing , Chen Ran , An Zhongwei , Chen Xinbing , Chen Pei
Published: September 2023

Developing fast-response liquid crystals (LCs) is an essential way to achieve low cost, high resolution, and good visual experience for augmented reality (AR) displays. In this paper, we optimized one new nematic LC mixture SNUP01 to meet the requirements of fast-response phase-only liquid crystal on silicon (LCoS) devices in AR displays. The photoelectric performance of this new LC mixture and three commercial LC mixtures were further comparatively evaluated, and the 2π phase-change response speed of this new LC mixture was extrapolated. The research results indicate that SNUP01 possesses high birefringence, moderate dielectric anisotropy, low viscoelastic coefficient, low activation energy, and high figure of merit values. When using this LC mixture at 25 °C @ λ = 633 nm, a 2π phase change can be achieved at 5 V with a total response time of up to millisecond response. Widespread applications of this LC mixture for AR displays are foreseeable.
Plant Growth in LED-Sourced Biophilic Environments Is Improved by the Biochar Amendment of Low-Fertility Soil, the Reflection of Low-Intensity Light, and a Continuous Photoperiod
Authors: Beatrice Peter , Miali Alessio , Baronti Silvia , Chiatante Donato , Montagnoli Antonio
Published: September 2023

Introducing plants in the design of biophilic indoor environments is fundamental for improving human health, well-being, and performance. Previous studies showed that the phenotype of the model plant Arabidopsis thaliana grown under LED-sourced CoeLux® lighting systems was characterized by low biomass production rates, a small leaf area, and a low lamina-to-petiole length ratio, suggesting the onset of a strong shade avoidance syndrome. Therefore, it is essential to identify new strategies to improve plant growth under these peculiar light conditions. In the present work, we investigated the effects of two growing media (i.e., low-fertility soil and soil-less substrate), solid and liquid fertilizers, manure, biochar, perlite, mirror reflection of light, and a 24 h photoperiod on A. thaliana plants growing under CoeLux® lighting systems at a light intensity of 30 μmol m−2s−1. We found that the biochar soil amendment to low-fertility soil increases both the above-ground plant biomass and leaf area. Furthermore, the application of a mirror behind the plants and a continuous photoperiod improves not only the biomass and the leaf area but also the lamina-to-petiole length ratio. The combination of different beneficial treatments can further boost plant growth in the low-intensity light environment characterizing the CoeLux® biophilic lighting systems.
Computer Vision Interaction Design in Sustainable Urban Development: A Case Study of Roof Garden Landscape Plants in Marine Cities
Authors: Zhang Longlong , Kim Chulsoo
Published: September 2023

The rapid urbanization and the increasing need for sustainable development have led to the emergence of green roof landscapes in ocean cities. These rooftop gardens provide numerous environmental benefits and contribute to the overall well-being of urban dwellers. However, optimizing the design and interaction experience of green roof landscapes requires the integration of intelligent technologies. This paper explores the application of computer visual design techniques, specifically 3DMAX modeling and virtual reality, in the intelligent interaction design of green roof landscape plants in ocean cities. Designers can use computer visual design (3DMAX) and other technologies to interact intelligently with the roof landscape in order to improve landscape design. Through case studies, this indicated that computer vision is excellent for image processing of rooftop landscapes and also demonstrates a high degree of compatibility between computer vision and green rooftop landscape plant design in marine cities. This paper highlights the significance of intelligent interaction design and computer visual design techniques in optimizing the integration of green roof landscape plants in ocean cities. It emphasizes the potential of 3DMAX modeling and VR technology in creating immersive and engaging experiences for designers, users, and stakeholders alike. The findings contribute to the growing body of knowledge in the field of sustainable urban development and provide insights for designers, policymakers, and researchers seeking to enhance green roof landscapes in ocean cities. The dissertation highlights the potential of using computer vision design techniques to enhance the roof garden landscaping process and advocates for more efficient and effective ways to design, visualize, and improve rooftop gardens by utilizing software equipped with computer vision technology such as 3DMAX, ultimately contributing to the advancement of sustainable urban landscapes.
Primary Screening of Microorganisms against Meloidogyne hapla (Chitwood, 1949) under the Conditions of Laboratory and Vegetative Tests on Tomato
Authors: Nekoval Svetlana N. , Churikova Arina K. , Chernyakovich Maxim N. , Pridannikov Mikhail V.
Published: September 2023

Highly adapted obligate endoparasites of the root system, root-knot nematodes (Meloidogyne spp.), cause great damage to agricultural crops. Our research is aimed at the assessment of nematicidal activity and effectiveness of antagonist fungal and bacterial strains against the most common type of root-knot nematode in the south of Russia. By means of molecular genetic identification, it was found that in the south of Russia, the species Meloidogyne hapla Chitwood, 1949 and Meloidogyne incognita (Kofoid and White, 1919) Chitwood, 1949 cause galls on the roots of open-ground and greenhouse tomato. Screening of microbial agents against second-stage juvenile (J2) M. hapla was carried out in the laboratory. At the end of the experiment, two liquid fungal cultures of Paecilomyces lilacinus BK-6 and Metarhizium anisopliae BK-2 were isolated, the nematicidal activity of which reached 100.0 and 70.2%, and exceeded the values of the biological standard (Nemotafagin-Mikopro) by 38.4% and 8.8%. The highest biological efficacy was noted in the liquid cultures of P. lilacinus BK-6, M. anisopliae BK-2, and Arthrobotrys conoides BK-8 when introduced into the soil before planting tomato. The number of formed galls on the roots was lower in comparison with the control by 81.0%, 75.5%, and 74.4%.
Unveiling the Potential of Algal Extracts as Promising Antibacterial and Antibiofilm Agents against Multidrug-Resistant Pseudomonas aeruginosa: In Vitro and In Silico Studies including Molecular Docking
Authors: El-Sapagh Shimaa , El-Shenody Rania , Pereira Leonel , Elshobary Mostafa
Published: September 2023

Multidrug-resistant Pseudomonas aeruginosa poses a global challenge due to its virulence and biofilm-forming ability, leading to persistent infections. This study had a dual focus: first, it aimed to investigate the biofilm activity and antibiotic resistance profiles of Pseudomonas aeruginosa isolates obtained from a fish-rearing farm. Second, it explored the potential of algal extracts as effective antibacterial and antibiofilm agents. The study analyzed 23 isolates of P. aeruginosa from the farm, assessing antibiotic resistance and biofilm formation. The antimicrobial and antibiofilm activities of two algal extracts, Arthrospira platensis (cyanobacteria) acetone extract (AAE) and Polysiphonia scopulorum (Rhodophyta) methanol extract (PME), were tested individually and combined (COE). The effects on biofilm-related gene expression were examined. AAE, PME, and COE were evaluated for antimicrobial and antibiofilm properties. Biofilm-related gene expression was measured and the extracts were analyzed for physicochemical properties and toxicity. Most P. aeruginosa isolates (86.9%) were antibiotic-resistant and formed biofilms. AAE, PME, and COE displayed promising antibacterial and antibiofilm effects, with COE being particularly effective. COE reduced a key biofilm-related gene expression. The fatty acid content (56% in AAE and 34% in PME) correlated with the effects. Specific compounds, such as phytol, bromophenol, and dihydroxy benzaldehyde, contributed to the activities. The extracts showed favorable characteristics and interactions with FabZ protein amino acids. This study suggests the potential of algal extracts as antibacterial and antibiofilm agents against drug-resistant infections. Further exploration in clinical applications is warranted.
Exploring Salinity Tolerance Mechanisms in Diverse Wheat Genotypes Using Physiological, Anatomical, Agronomic and Gene Expression Analyses
Authors: Hussein Mohammed A. A. , Alqahtani Mesfer M. , Alwutayd Khairiah M. , Aloufi Abeer S. , Osama Omnia , Azab Enas S. , Abdelsattar Mohamed , Hassanin Abdallah A. , Okasha Salah A.
Published: September 2023

Salinity is a widespread abiotic stress that devastatingly impacts wheat growth and restricts its productivity worldwide. The present study is aimed at elucidating biochemical, physiological, anatomical, gene expression analysis, and agronomic responses of three diverse wheat genotypes to different salinity levels. A salinity treatment of 5000 and 7000 ppm gradually reduced photosynthetic pigments, anatomical root and leaf measurements and agronomic traits of all evaluated wheat genotypes (Ismailia line, Misr 1, and Misr 3). In addition, increasing salinity levels substantially decreased all anatomical root and leaf measurements except sclerenchyma tissue upper and lower vascular bundle thickness compared with unstressed plants. However, proline content in stressed plants was stimulated by increasing salinity levels in all evaluated wheat genotypes. Moreover, Na+ ions content and antioxidant enzyme activities in stressed leaves increased the high level of salinity in all genotypes. The evaluated wheat genotypes demonstrated substantial variations in all studied characters. The Ismailia line exhibited the uppermost performance in photosynthetic pigments under both salinity levels. Additionally, the Ismailia line was superior in the activity of superoxide dismutase (SOD), catalase activity (CAT), peroxidase (POX), and polyphenol oxidase (PPO) enzymes followed by Misr 1. Moreover, the Ismailia line recorded the maximum anatomical root and leaf measurements under salinity stress, which enhanced its tolerance to salinity stress. The Ismailia line and Misr 3 presented high up-regulation of H+ATPase, NHX2 HAK, and HKT genes in the root and leaf under both salinity levels. The positive physiological, anatomical, and molecular responses of the Ismailia line under salinity stress were reflected on agronomic performance and exhibited superior values of all evaluated agronomic traits.
A New Essential Oil from the Native Andean Species Nectandra laurel Klotzsch ex Nees of Southern Ecuador: Chemical and Enantioselective Analyses
Authors: Gilardoni Gianluca , Enríquez Aníbal A. , Maldonado Yessenia E. , Cumbicus Nixon , Malagón Omar
Published: September 2023

The leaves of Nectandra laurel Klotzsch ex Nees, belonging to the family, Lauraceae, were collected in the province of Loja (Ecuador), dried, and analytically steam-distilled. An unprecedented essential oil was obtained, with a 0.03% yield by weight of dry plant material. The volatile fraction was submitted to qualitative (GC-MS) and quantitative (GC-FID) chemical analysis, on two orthogonal stationary phases. Seventy-eight compounds were detected and quantified on at least one column. The essential oil was dominated by sesquiterpene hydrocarbons (53.0–53.8% on the non-polar and polar stationary phase, respectively), followed by oxygenated sesquiterpenoids (18.9–19.0%). A third group was constituted by metabolites of other origins, mainly aliphatic compounds, apparently derived from the acetate pathway (11.7–8.5%). The major components of the EO (≥3.0% with at least one column) were δ-selinene (30.5–28.8%), δ-cadinene (5.4–6.4%), epi-α-cadinol (4.9–5.2%), an undetermined compound with a molecular weight of 204 (3.4–4.2%), α-pinene (3.3–2.9%), and α-cadinol (2.9–3.0%). Finally, the essential oil was submitted to enantioselective analysis, on two β-cyclodextrin-based chiral selectors, determining the enantiomeric distribution of seven chiral terpenes. Among them, (1R,5R)-(+)-α-pinene, (1R,5R)-(+)-β-pinene, and (R)-(−)-α-phellandrene were enantiomerically pure, whereas camphene, borneol, α-copaene, and α-terpineol were present as scalemic mixtures.
Integrative Analysis of Metabolome and Transcriptome Revealed Lutein Metabolism Contributed to Yellow Flower Formation in Prunus mume
Authors: Ding Aiqin , Bao Fei , Yuan Xi , Wang Jia , Cheng Tangren , Zhang Qixiang
Published: September 2023

Prunus mume is a famous ornamental woody tree with colorful flowers. P. mume with yellow flowers is one of the most precious varieties. Regretfully, metabolites and regulatory mechanisms of yellow flowers in P. mume are still unclear. This hinders innovation of flower color breeding in P. mume. To elucidate the metabolic components and molecular mechanisms of yellow flowers, we analyzed transcriptome and metabolome between ‘HJH’ with yellow flowers and ‘ZLE’ with white flowers. Comparing the metabolome of the two varieties, we determined that carotenoids made contributions to the yellow flowers rather than flavonoids. Lutein was the key differential metabolite to cause yellow coloration of ‘HJH’. Transcriptome analysis revealed significant differences in the expression of carotenoid cleavage dioxygenase (CCD) between the two varieties. Specifically, the expression level of PmCCD4 was higher in ‘ZLE’ than that in ‘HJH’. Moreover, we identified six major transcription factors that probably regulated PmCCD4 to affect lutein accumulation. We speculated that carotenoid cleavage genes might be closely related to the yellow flower phenotype in P. mume. Further, the coding sequence of PmCCD4 has been cloned from the ‘HJH’ petals, and bioinformatics analysis revealed that PmCCD4 possessed conserved histidine residues, ensuring its enzymatic activity. PmCCD4 was closely related to PpCCD4, with a homology of 98.16%. Instantaneous transformation analysis in petal protoplasts of P. mume revealed PmCCD4 localization in the plastid. The overexpression of PmCCD4 significantly reduced the carotenoid content in tobacco plants, especially the lutein content, indicating that lutein might be the primary substrate for PmCCD4. We speculated that PmCCD4 might be involved in the cleavage of lutein in plastids, thereby affecting the formation of yellow flowers in P. mume. This work could establish a material and molecular basis of molecular breeding in P. mume for improving the flower color.
Investigation on the Influence of Process Parameters on the Mechanical Properties of Extruded Bio-Based and Biodegradable Continuous Fiber-Reinforced Thermoplastic Sheets
Authors: Lang Maximilian , Neitzel Benedikt , MohammadKarimi Shiva , Puch Florian
Published: September 2023

The use of bio-based and biodegradable matrix materials in fiber-reinforced polymers (FRPs) is an approach to reduce the consumption of fossil resources and the amount of polymer waste. This study aims to assess the influence of the process parameters on the resulting mechanical properties of extruded bio-based and biodegradable continuous fiber-reinforced thermoplastics (CFRTPs) in the form of sheets. Therefore, the impregnation temperature during the production of PLA/flax fiber composites is varied between 220 °C and 280 °C, and the consolidation pressure, between 50 bar and 90 bar. A design of experiments approach is used. Fiber contents of 28.8% to 34.8% and void contents of 6.8% to 15.5% are determined for the composites by optical measurements. To assess the mechanical properties, tensile tests are performed. Using the evaluation software Minitab, a strong negative influence of the consolidation pressure on the tensile modulus and the tensile strength is observed. Increasing the pressure from 50 bar to 90 bar results in a reduction in the tensile modulus of 50.7% and a reduction in the tensile strength of 54.8%, respectively. It is assumed that this is due to fibers being damaged by the external force exerted onto the materials during the consolidation process in the calender. The influence of the impregnation temperature on the mechanical properties cannot be verified.
On the Analysis of Cryogels and Xerogels Using Cellulose Nanofibers and Graphene Oxide
Authors: Moggio Bianca Cristina , Bergamasco Rosangela , Andrade Cid Marcos Gonçalves , Aylon Linnyer Beatrys Ruiz
Published: September 2023

Aerogels are highly porous and ultralight three-dimensional materials with great potential for various applications. To obtain highly porous and structurally stable aerogels, a carefully designed synthesis process is required. These materials offer flexibility in manipulating their properties, allowing the incorporation of modifying agents according to specific needs. In this study, compounds were synthesized using graphene oxide (GO) and nanocellulose fibers (NFC) through the hydrothermal reduction methodology. Two drying techniques were employed: lyophilization and oven evaporation, resulting in materials called cryogel and xerogel, respectively. Various parameters that can interfere with the properties of these nanomaterials were evaluated. The results indicated that the cryogel dried by lyophilization provided the best applicability due to its structural flexibility after compressions, whereas the xerogel obtained through the oven evaporation process resulted in a compound with high rigidity and disintegration. Structural characterizations demonstrated the successful development of the precursors and promising characteristics in the synthesized nanomaterials. With its flexibility, approximately 98% porosity, low shrinkage rate, light weight, and electrical conductivity, the developed cryogel showed high potential in various applications, such as pressure sensors, electromagnetic shielding, and other research and development fields.
Defatted Black Soldier Fly Larvae Meal as an Alternative to Soybean Meal for Broiler Chickens
Authors: Chobanova Sashka , Karkelanov Nikolay , Mansbridge Stephen Charles , Whiting Isobel Margaret , Simic Antonija , Rose Stephen Paul , Pirgozliev Vasil Radoslavov
Published: September 2023

The production of soybean meal (SBM) has a substantial impact on the environment and reducing its inclusion in poultry diets by using alternative protein sources, such as insect meal, is an important challenge for nutritionists. This study aimed to compare the productive performance of broiler chickens fed one of two isonitrogenic (195 g/kg CP) and isocaloric (12.91 MJ/kg) diets. The first diet contained SBM as the main protein source, whereas SBM was completely replaced by defatted meal from Black Soldier Fly larvae (Hermetia illucens L.; BSFL) in the second diet. Compared to the BSFL diet, the final body weight (BW) and weight gain (WG) of birds fed the SBM diet was ~17% greater and feed was utilised 19% more efficiently (p < 0.05). The differences in WG and FCR were supported by improved energy metabolism metrics, fat digestibility and digestibility of acid detergent fibres (ADFD) (p < 0.05). The present study shows that a complete replacement of dietary SBM with BSFL meal must be achieved with care, ensuring that all other factors (e.g., insect processing technology, feed additive supplementation, non-protein nitrogen accounting, mineral balance, fatty acid profile, amino acid supplementation) have been considered.
A Full-State Reliability Analysis Method for Remanufactured Machine Tools Based on Meta Action and a Markov Chain Using an Exercise Machine (EM) as an Example
Authors: Luo Yueping , Xiao Yongmao
Published: September 2023

The reliability of an RMT can be regarded as an important indicator customers can use to recognize its quality; however, it is difficult to implement a full-state reliability analysis of an RMT due to its complicated structural functions. Therefore, a full-state reliability analysis model is proposed herein based on meta action (MA) and a Markov chain for remanufactured exercise machine tools (REMTs). First, an analysis was carried out on individual levels by integrating the MAU decomposition method, and an MAU fault tree model was established layer by layer for the REMT. Second, full-state modeling was performed in view of the MAU characteristics of the REMT, whose operation processes are divided into MAU normal and failure states. A Markov decision-making process was introduced to integrate MAU states and establish our model, which was solved by means of an analytical method for the evaluation of reliability. Finally, an example of a remanufactured machine tool spindle is given to verify the effectiveness of the method.
Advances in Triboelectric Nanogenerators for Sustainable and Renewable Energy: Working Mechanism, Tribo-Surface Structure, Energy Storage-Collection System, and Applications
Authors: Trinh Van-Long , Chung Chen-Kuei
Published: September 2023

Triboelectric nanogenerators (TENGs) are emerging as a form of sustainable and renewable technology for harvesting wasted mechanical energy in nature, such as motion, waves, wind, and vibrations. TENG devices generate electricity through the cyclic working principle of contact and separation of tribo-material couples. This technology is used in outstanding applications in energy generation, human care, medicinal, biomedical, and industrial applications. TENG devices can be applied in many practical applications, such as portable power, self-powered sensors, electronics, and electric consumption devices. With TENG energy technologies, significant energy issues can be reduced or even solved in the near future, such as reducing gas emissions, increasing environmental protection, and improving human health. The performance of TENGs can be enhanced by utilizing materials with a significant contrast in their triboelectrical characteristics or by implementing advanced structural designs. This review comprehensively examines the recent advancements in TENG technologies for harnessing mechanical waste energy sources, with a primary focus on their sustainability and renewable energy attributes. It also delves into topics such as optimizing tribo-surface structures to enhance output performance, implementing energy storage systems to ensure stable operation and prolonged usage, exploring energy collection systems for efficient management of harvested energy, and highlighting practical applications of TENG in various contexts. The results indicate that TENG technologies have the potential to be widely applied in sustainable energy generation, renewable energy, industry, and human care in the near future.
Special Issue on “Secondary Metabolites: Extraction, Optimization, Identification and Applications in Food, Nutraceutical, and Pharmaceutical Industries”
Authors: Abu-Reidah Ibrahim M.
Published: September 2023

There is a growing interest in utilizing natural plant extracts in the food and beverage industries [...]
Semantic Hybrid Signal Temporal Logic Learning-Based Data-Driven Anomaly Detection in the Textile Process
Authors: Huo Xu , Hao Kuangrong
Published: September 2023

The development of sensor networks allows for easier time series data acquisition in industrial production. Due to the redundancy and rapidity of industrial time series data, accurate anomaly detection is a complex and important problem for the efficient production of the textile process. This paper proposed a semantic inference method for anomaly detection by constructing the formal specifications of anomaly data, which can effectively detect exceptions in process industrial operations. Furthermore, our method provides a semantic interpretation of exception data. Hybrid signal temporal logic (HSTL) was proposed to improve the insufficient expressive ability of signal temporal logic (STL) systems. The epistemic formal specifications of fault offline were determined, and a data-driven semantic anomaly detector (SeAD) was constructed, which can be used for online anomaly detection, helping people understand the causes and effects of anomalies. Our proposed method was applied to time-series data collected from a representative textile plant in Zhejiang Province, China. Comparative experimental results demonstrated the feasibility of the proposed method.
Quantitative Differences in Rumen Epithelium Proteins in Lambs Fed Wheat, Perennial Wheat, or Perennial Wheat plus Lucerne
Authors: Bond Jude Jessie , Refshauge Gordon , Newell Matthew T. , Holman Benjamin W. B. , Wheeler David , Woodgate Serey , Kamath Karthik S. , Hayes Richard C.
Published: September 2023

The value of crops such as perennial wheat (PW) for grain and grazing compared to conventional wheat (W), or the addition of lucerne to PW (PWL) is still being determined. This research sought to determine if these diets were associated with changes in the membranebound proteins that transport nutrients in the rumen epithelium (RE). Crossbred ewes (Poll Dorset × Merino) were fed W, PW, or PWL (50:50) fresh-cut forage ad libitum for 4 weeks. Average daily gain (ADG; p < 0.001) was highest in the W-fed lambs compared to the PW and PWL. Metabolisable energy intake (MEI) was higher in lambs fed W (p < 0.001) compared to PW and PWL. In pairwise comparisons of the PW and PWL diet group we found protein abundance was significantly (p < 0.05, FDR < 0.05, Benjamini p < 0.05) different in fatty acid metabolism, oxidative phosphorylation, and biosynthesis of cofactors pathways. There were not any differences in protein abundance related to nutrient transport or energy metabolism in the RE between W- vs. PW- and W- vs. PWL-fed lambs. However, in the PW- vs. PWL-fed lambs, there was a difference in the level of proteins regulating the metabolism of fatty acids and energy production in the mitochondria of the rumen epithelium.
Promoting Open Access in Research-Performing Organizations: Spheres of Activity, Challenges, and Future Action Areas
Authors: Pampel Heinz
Published: September 2023

Open access (OA) has become a critical issue in science policy and affects a wide range of activities in universities and research labs. Research-performing organizations (RPOs), defined as publicly funded universities and research institutions, face significant challenges in shaping the OA transformation. This article examines the spheres of activity available to RPOs for shaping the OA transformation, using a categorization of 22 spheres of activity related to OA. These spheres of activity include strategy and communication, services and infrastructures, business relationships with publishers, and collaborations. Current challenges and future action areas in promoting OA are also described, providing support for RPOs in handling OA and highlighting key issues. The categorization can serve as a tool for systematically assessing OA activities at RPOs and shows that OA is a cross-cutting issue in these organizations. Collaboration on OA activities, both within and beyond organizations, presents a challenge. To effectively promote OA, it is crucial to strengthen the interaction between funding agencies and RPOs. Libraries are critical stakeholders, playing a vital role in advancing OA at the local, national, and international levels in partnership with RPO management and other partners in faculty, administration, and information technology.
Christian Nationalism and Politics in Ghana
Authors: Haynes Jeffrey
Published: September 2023

This paper argues that Christian nationalism is a significant religious and political ideology in Ghana, a west African country whose population is 70 per cent Christian. In Ghana, Christian nationalism is not simply Christians seeking to make their collective voice heard on issues of national interest. Instead, Christian nationalists pursue a religious and political project with the aim of remaking Ghana according to their values and beliefs. To embed and consolidate influence, prominent Christian nationalists in Ghana both cultivate ‘insider’ status with powerful political elites and develop a high media profile in order to promote their views, encourage the government to adopt their policies, and increase the number of followers. This article makes two main arguments. First, Christian nationalists in Ghana seek to change public policy to remake the country according to their understanding of Christian morals and ethical behaviour. Second, Christian nationalists in Ghana pursue their goal—to build the kingdom of God on earth—in three main ways: (1) strong support for Ghana’s national cathedral, seen as a celebration of national unity and social cohesion; (2) attacks on alleged immorality of Ghana’s LGBTQ+ community; (3) vilify followers of minority religions to encourage the view that Christianity is the most appropriate religion in Ghana and that other religions are inferior.
God’s Moral Perfection as His Beneficent Love. Comment on Craig (2023). Is God’s Moral Perfection Reducible to His Love? Religions 14: 140
Authors: Kinghorn Kevin
Published: September 2023

William Lane Craig insists that I am wrong in reducing God’s moral goodness to his beneficent aim of drawing all people to himself. For Craig, God’s moral goodness, best conceived in terms of righteousness, must also include God’s retributive justice toward the wicked, who deserve the punishment they receive. My response is that Craig’s argument rests on two assumptions about value, neither of which, I argue, Christian theists have good reason to affirm.
Multi-Scale Engineering Geological Zonation for Linear Projects in Mountainous Regions: A Case Study of National Highway 318 Chengdu-Shigatse Section
Authors: Li Yongchao , Qi Shengwen , Zheng Bowen , Yao Xianglong , Guo Songfeng , Zou Yu , Lu Xiao , Tang Fengjiao , Guo Xinyi , Waqar Muhammad Faisal , Zada Khan
Published: September 2023

In response to the challenges of long crossing distances and difficult site selection for linear engineering projects in mountainous areas, this article proposes a multi-scale engineering geological zoning (EGZ) method. This method is based on the linear engineering construction stage and transitions from regional EGZ to EGZ of key sections (areas with poor or worst engineering geological conditions). This method not only ensures the effect of EGZ but also reduces the workload. When carrying out the EGZ of key sections, the assessment ideas of geological disaster hazards were taken into consideration. An improved method for calculating the time probability and magnitude probability of disaster occurrence is proposed. Taking the National Highway 318 Chengdu-Shigatse section as an example, EGZ was carried out. Its results revealed that the Nyingchi section was the key section with poor and worst engineering geological conditions. EGZ of the key section showed that the areas with poor and worst engineering geological conditions were mainly distributed in the curved sections on the northern side of the linear project. The proposed method in this article provides guidance for EGZ for linear engineering projects in mountainous areas.
Assessment of Pavement Structural Conditions and Remaining Life Combining Accelerated Pavement Testing and Ground-Penetrating Radar
Authors: Liu Zhen , Yang Qifeng , Gu Xingyu
Published: September 2023

The inspection and monitoring of structural conditions are crucial for the maintenance of semi-rigid base pavement. To achieve the inverse calculation of material parameters and obtain the mechanical response of asphalt pavement, a method of modulus correction by reducing the error between tested and simulated strains was first developed. The relationship between the temperature at various depths within the pavement structure and atmospheric temperature was effectively demonstrated using a dual sinusoidal regression model. Subsequently, pavement monitoring data illustrated that as loading weight and temperature increased and loading speed decreased, the three-way strain of the asphalt layer increased. Thus, the relationship model between loading conditions and three-way strain was established with a good fitting degree (R2 > 0.95). The corrected modulus was obtained by approximating the error between simulated and measured strains. Then, the finite element analysis was performed to calculate key mechanical index values under various working conditions and predict the fatigue life of asphalt and base layers. Finally, ground-penetrating radar (GPR) detection was performed, and the internal pavement condition index was defined for quantitative assessment of structure conditions. The results show that there is a good correlation between the internal pavement condition index (IPCI) and remaining life of pavement structure. Therefore, our works solve the problems of the parameter reliability of pavement structures and quantitative assessment for structural conditions, which could support the performance prediction and maintenance analysis on asphalt pavement with a semi-rigid base.
GNSS Receiver Antenna Absolute Field Calibration System Development: Testing and Preliminary Results
Authors: Tupek Antonio , Zrinjski Mladen , Švaco Marko , Barković Đuro
Published: September 2023

For high-precision Global Navigation Satellite Systems (GNSS) positioning based on carrier-phase measurements, knowledge of the GNSS receiver antenna electrical signal reception characteristics, i.e., phase center, is crucial. Numerous studies have led to the understanding of the influence of GNSS receiver antenna phase center corrections (PCCs) on GNSS positioning accuracy and other estimated parameters (e.g., receiver clock estimates, ambiguities, etc.). With the goal of determining the PCC model of GNSS receiver antennas, only a few antenna calibration systems/facilities are in operation or under development worldwide. The International GNSS Service (IGS) publishes type-mean PCC models for almost all geodetic-grade GNSS antennas. However, the type-mean models are not perfect and do not fully reflect the signal reception properties of individual GNSS receiver antennas. Relevant published scientific research has shown that the application of individual PCC models significantly improves the accuracy of GNSS positioning and other estimated parameters. In this article, the new automated GNSS antenna calibration system, recently developed at the Laboratory for Measurements and Measuring Technique (LMMT) of the Faculty of Geodesy of the University of Zagreb in Croatia, is presented. The developed system is an absolute field calibration system based on the utilization of a Mitsubishi MELFA 6-axis industrial robot. During calibration, the robot tilts and rotates the GNSS antenna under test (AUT) around a fixed point within the antenna. The antenna PCC modelling is based on time-differenced double-difference carrier-phase observations. Our preliminary results for the Global Positioning System (GPS) L1 (G01) frequency show a submillimeter repeatability of the estimated PCC model and a submillimeter agreement with the Geo++ GmbH calibration results.
Bureaucratic Violence in the Residency Application Process: Findings from a Mixed Methods Cross-Sectional Survey of Migrant Women in Spain
Authors: Bentley Abigail
Published: September 2023

Bureaucratic violence linked to immigration systems and residency applications, such as confusing and cumbersome administrative processes, discriminatory practices and a lack of accountability, act as significant post-migration stressors in destination countries that can impact migrant wellbeing. The behavior of public officials within these systems, referred to as ‘street-level bureaucrats’, can amplify stress through the use of discretion in interpreting legal requirements. The experiences of migrant women in attempting to obtain resident status in Spain have not been well documented. This article makes a novel contribution to the literature by aiming to understand the barriers faced by migrant women when applying for residency in Spain, and how experiences differ by socio-demographic subgroups. The study analysed mixed-methods data collected via an online survey of migrant women living in Valencia, Spain. A lack of information, communication barriers and difficulty meeting the stringent requirements of visa applications emerged as some of the main barriers to residency, with women from Africa, Asia or the Middle East being most likely to encounter barriers. Policy makers should seek to enhance transparency, standardize processes and improve communication for migrants interacting with the immigration system in order to reduce barriers and create more accessible pathways to residency in Spain.
Influences of Start-Up’s Financial Intermingling on Entrepreneurial Stress in Sustainable Family Businesses: Mediation Effect of Work–Family Balance
Authors: Choi Jucheol , Kessler Daniel
Published: September 2023

One factor affecting entrepreneurial success at the small-business start-up level is the impact on family life. This study examines the effects of intermingling financial resources on the quality of life of families operating businesses in South Korea. Based on the Global Entrepreneurship Monitor 2022 assessment, which ranks South Korea 9th out of 51 economies, South Korea emerges as a promising area for scholarly research in this area. The analysis results are as follows: First, when financial intermingling occurs (when family and business finances are merged to some degree), entrepreneurial stress was found to be higher. Second, financial intermingling between family funds and business finances increased entrepreneurial stress by impairing the work–family balance. Third, when one spouse is more dedicated to supporting start-ups, entrepreneurial stress caused by the pressure to use family funds as business finances is greater. As small-business start-ups often require creative means to generate primary financing, resource exchanges between families and businesses may sometimes be a regrettable necessity. However, if the potential downsides of resource exchange are ignored, and resource exchange frequently occurs over a long period of time, it can place significant stress on all parties and may adversely affect the sustainability of a family business.