bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating the Rights-based and Capability Approaches in the Analysis of Maternal Healthcare Utilization in sub-Saharan Africa: A Multilevel Modelling Study
Authors: Simona Simona , Likando Nakena , Banda Andrew , Phiri Million
Published: May 2022

Background: The rights-based and capability approaches have received increased attention relative to maternal health in the aftermath of the 2015 Millenium Development Goals (MDGs). This is in view of the sub-optimal progress gained in reducing maternal and child mortality, especially in developing countries. Despite the combined potential of these models, limited empirical studies testing their viability in maternal health exist. This is what this study sought to accomplish. Method: We combined several datasets for this study, including the Demographic Health Survey (DHS), World Development Indicators, the World Governance Indicators and Freedom House. Using the R programming environment and the R2MLwiN package, Bayesian multilevel logistic regression models were applied on three indicators of maternal healthcare (antenatal care visits, institutional delivery, and postnatal check-ups) in relation to selected individual, community and country-level factors representing right-based and capability approaches. All the models report posterior odd ratios (POR).Results: The results support the potence of the rights-based and capability approaches in bolstering maternal healthcare utilization in sub-Saharan Africa. Living in countries which have high freedom status (POR = 1.19) and higher female secondary school enrolments (POR = 1.54) increases the odds of adequate antenatal care. Living in countries with high freedom status (POR =1.33) and higher voice and accountability (POR = 1.72) also increases the odds of institutional delivery. Similar results are reported for postnatal care where country freedom status (POR = 1.89), voice and accountability (POR = 1.25) and female school enrolment (POR = 1.41) are significant predictors. Conclusion: The results imply that the rights-based and capability approaches have the potential to enhance maternal healthcare utilization in sub-Saharan Africa. Therefore, policy strategies emphasizing on freedoms, accountability and individual capability functionings should be encouraged in the pursuit of achieving Sustainable Development Goals number 3.
Prenatal genetic diagnosis in a fetus with tetrasomy 18p from maternal trisomy 18p: a case report
Authors: Peng Can , LinPeng SiYuan , Bu Xiufen , Jiang XuanYu , Hu LanPing , He Jun , Zhou ShiHao
Published: May 2022

Background: Tetrasomy 18p syndrome is a very rare chromosomal disorder that is caused by the presence of isochromosome 18p.Most tetrasomy 18p cases are de novo cases,maternal origin trisomy 18p is a very rare condition.At present, only 4 cases of maternal origin trisomy 18p have been reported.This was the the fifth from maternal trisomy 18p,the mother has no apparent disease phenotype.Case presentation: We hereby report a case of a fetus with normal ultrasound features, the Karyotyping and Single Nucleotide Polymophism array (SNP array) confirmed tetrasomy 18p.The mother and grandfather are phenotypically normal and healthy,but with trisomy 18p was confirmed by conventional karyotyping and SNP array.Conclusions: We report a family with an 18p trisomic mother and grandfather,18p tetrasomic fetus,the mother and grandfather are phenotypically normal. The findings could provide a reference for the genetic counseling of trisomy
Oligopeptides derived from solid-state fermented cottonseed meal showed good antioxidant activity in both in vitro and in vivo studies
Authors: Liu Jiancheng , Li Fengming , Zhang Xiaoyang , Nie Cunxi , Zhang Wenju
Published: May 2022

To determine the in vitro and in vivo antioxidant activities of oligopeptides derived from solid-state fermented cottonseed meal. The free radical scavenging in vitro as well as the antioxidative function and lipid metabolism in an oxidized stress mice model was applied in the present study and results indicated that the oligopeptides showed good antioxidant activity both in vitro and in vivo. A positive correlation between the oligopeptides content, free radical scavenging ability and total antioxidant activity was observed when the oligopeptides concentration ranged from 0.5 mg/mL to 8 mg/mL. While the in vivo study indicated that feeding oligopeptides increased the activities of T-AOC, T-SOD, CAT, GSH-Px in the liver and serum of mice (p<0.05) and decreased the content of MDA (p<0.01). Our results indicated that the oligopeptides showed good antioxidant activity and could improve the antioxidant capacity as well as blood lipid metabolism in mice.
Potential antiviral effects of pantethine against SARS-CoV-2
Authors: M Abou-Hamdan , R Saleh , S Mani , P Dournaud , M Metifiot , ML Blondot , ML Andreola , F Abdel Sater , Max De Reggi , P Gressens , M Laforge
Published: May 2022

SARS-CoV-2 interacts with cellular cholesterol during many stages of its replication cycle. Pantethine was reported to reduce total cholesterol levels and fatty acid synthesis and potentially alter different processes that might be involved in the SARS-CoV-2 replication cycle. Here, we explored the potential antiviral effects of pantethine in two in vitro experimental models of SARS-CoV-2 infection.Pantethine reduced the infection of cells by SARS-CoV-2 in both preinfection and postinfection treatment regimens. Accordingly, cellular expression of the viral spike and nucleocapsid proteins was substantially reduced, and we observed a significant reduction in viral copy numbers in the supernatant of cells treated with pantethine. In addition, pantethine inhibited the infection-induced increase in TMPRSS2 and HECT E3 ligase expression in infected cells as well as the increase in antiviral interferon-beta response and inflammatory gene expression in Calu-3a cells. Our results demonstrate that pantethine, which is well tolerated in humans, was very effective in controlling SARS-CoV-2 infection and might represent a new therapeutic drug that can be repurposed for the prevention or treatment of COVID-19 and long COVID syndrome.
An Efficient and Simple Algorithm for Solving Fractional Order Differential Equations
Authors: Pérez Pablo
Published: May 2022

It is presents and discuss an algorithm to generate the numerical solution of fractional differential equations in the form: Dα ∗ x(t) = f(t, x(t)), x(0) = x0, with α ∈ R +, where Dα ∗ x(t) is the derivative of order α in the sense of Caputo of the function x(t). The algorithm is based on a variable change that suppresses the fractional integral kernel that enables us to establish a simple first order quadrature for the operator of fractional integration. We extend the result to a wider class of fractional differential equations, and conclude the article with numerical examples that show the effectiveness and convenience of the application of our algorithm.
On the solution of the Navier–Stokes system in three-dimensions
Authors: Thambynayagam R. K. Michael
Published: May 2022

A few basic, intuitive, properties of the Navier-Stokes system of equations for incompressible fluid flows are discussed in this paper. We present a rephrased interpretation of the Navier-Stokes equation. Next, for a given smooth solenoidal initial velocity vector field, we derive a spatially periodic solution of velocity and pressure fields that span the entire unbounded domain in three-dimensions. In this solution all three velocity components depend non-trivially on all three Cartesian coordinate directions.2000 Math Subject Classification: 35Q30, 76D05
Data Note on social networking sites and their impact on self-esteem and social capital formation among Emerging adults of Idukki, Kerala.
Authors: MPH Athulya Thomas , Kannan Srinivasan
Published: May 2022

This data note on Social networking sites (SNS) and their impact on social esteem and social formation is associated with human relationships in the context of decreased space due to increased use of digital communication. The participants of this data are emerging adults using digital devices and interact with their friends in the virtual world that affected physical, emotional, social and cognitive development. The data note aims to organise data set on the use of Social networking sites that influences social capital formation among emerging adults. It is the data of a cross-sectional survey conducted among 455 emerging adults who studied undergraduate courses in the Idukki district using the cluster sampling method. Data was collected using a self-reported questionnaire, having details on the pattern of SNS usage, self-esteem using the Rosenberg scale, and social capital formation. There were 56% of Arts and Science students, 14% of Medical students and 30% of engineering students. Data is archived on psycharchives.org with details on Dataset, Code sheet, Tool in English, Tool in Malayalam, and Consent Form. All data are complete and the actual data is available in CSV format with the codebook for each and every variable in the data file. The data will be useful for future studies on self-esteem, social capital formation among emerging adults around the world. In addition, the usage pattern of SNS will give more details on emerging adults’ access to those sites.
Predictors of 30-Day Mortality Using Machine Learning Approach following Carotid Endarterectomy: An Insight from National Surgical Quality Database.
Authors: Mohamed Ahmed , Fatima Nida , Ahmed Ayman Zakaria , Shuaib Ashfaq , Saqqur Maher
Published: May 2022

BACKGROUND
Pre-operative prognostication of 30-day mortality in patients with carotid endarterectomy (CEA) can optimize surgical risk stratification and guide the decision-making process to improve survival. To develop and validate a set of predictive variables of 30-day mortality following CEA.
METHODS
The patient cohort was identified from the American College of Surgeons National Surgical Quality Improvement Program (2005–2016). We performed logistic regression (enter, stepwise and forward) and least absolute shrinkage and selection operator (LASSO) method for selection of variables, which resulted in 28-candidate models. The final model was selected based upon clinical knowledge and numerical results.
RESULTS
Statistical analysis included 65,807 patients with 30-day mortality in 0.7% (n = 466) patients. The median age of our cohort was 71.0 years (range, 16–89 years). The model with 9-predictive factors which included: age, body mass index, functional health status, American society of anesthesiologist grade, chronic obstructive pulmonary disorder, preoperative serum albumin, preoperative hematocrit, preoperative serum creatinine and preoperative platelet count—performed best on discrimination, calibration, Brier score and decision analysis to develop a machine learning algorithm. Logistic regression showed higher AUCs than LASSO across these different models. The predictive probability derived from the best model was converted into an open-accessible scoring system.
CONCLUSION
Machine learning algorithms show promising results for predicting 30-day mortality following CEA. These algorithms can be useful aids for counseling patients, assessing pre-operative medical risks, and predicting survival after surgery.
Algorithm Simulation of an Efficient Strategy for Green Cloud Computing
Authors: Abiodun Moses Kazeem
Published: May 2022

In order to reduce the energy costs of running cloud computing services, this study looked into the methodologies and algorithms used in Green Cloud Computing (GCC). Huge datacenters and network transferring services need a lot of energy, which results in a lot of CO2. As a result, the GCC concept has arisen and evolved in order to reduce electrical power energy consumption and worldwide carbon dioxide emissions while also maintaining the services' long-term sustainability, dependability, and efficiency. In this research work, Cloud Analyst simulation software was used to mimic six datacenters in regular operation for six users in diverse locations around the world during a 365-day period. The TLB and ORTP Service Broker algorithm combination is the ideal algorithm combination because it has the fastest reaction time, which means it uses fewer resources and equipment, saving power and money. On the other side, the ESCELB Policy and ORTP Broker is the worst algorithm combination since it takes the longest time to respond, consumes more power, and increases overall cost. As a result, the study concludes that TLB and ORTP strategies should be implemented for effective green cloud computing in a safer environment.
Viral Respiratory Diseases on Sorok Island during the Pandemic
Authors: Lee Jong-Hoon , Kanwar Badar A. , Khattak Asif , Balentine Jenny , Cho Seongcheol , Choi Tae-young , Lee Keum-ho , Minh Tuan Nguyen Ngoc , Kast Richard E. , Lee Chul Joong , Bourbeau Jean , Altschuler Eric L. , Sergi Consolato , Huy Ngoc Nguyen , Lee So Jeong , Choi Su-Hee , Oh Sang-Suk , Park Jungwuk , Sohn Mun-Gi , Coleman Michael D.
Published: May 2022

Background: Dapsone is helpful in the molecular regulation of inflammasome activation, ubiquitin, one/two-electron oxidation, ubiquitination cascade, and myeloperoxidase/halide system. Objective: To study whether lung inflammation, inflammatory cytokine production, viral RNA, and sustained interferon (IFN) response by dapsone are responsible for its observed preventive treatment effects, functioning as a competitor against viral diseases. Methods: We compared Hansen's disease (HD) patients with viral respiratory diseases (VRDs) after prescribing dapsone as a standard treatment from 2005 to 2019. Results: The 3705 VRD participants who received the dapsone intervention compared to the 1172 VRD participants in the control group demonstrated T2 (M = 269.88, SD = 88.70, 95% CI 266.13-273.62, p-value < .00001):T3 (M = 59.75, SD = 93.36, 95% CI 51.36-68.14, p-value < .00001) definitely proves that VRD is very low when dapsone is taken, and very high when not taken. The t-value is −3.42, and the p-value is 0114. (significant at p < 0.05). It demonstrated significantly more prevalence of VRD in the DDS unprescribed group. We designed the Factor consisting of the dapsone taking group and anti-Alzheimer's disease drug (AAD) taking Alzheimer's disease (AD) diagnosed group, and it was strongly negatively correlated with the prevalence of Bronchitis and chronic obstructive pulmonary disease (COPD). It means that dapsone treated and AAD exacerbated them, but both had nothing to do with Pneumonia.Conclusion: This study provides theoretical clinical data that dapsone prevents and treats viral respiratory diseases and their related Bronchitis and COPD during the pandemic; moreover, AAD should be stopped.
Probing the particle spectrum of nature with evaporating black holes
Authors: Baker Michael J. , Thamm Andrea
Published: May 2022

Photons radiated from an evaporating black hole in principle provide complete information on the particle spectrum of nature up to the Planck scale. If an evaporating black hole were to be observed, it would open a unique window onto models beyond the Standard Model of particle physics. To demonstrate this, we compute the limits that could be placed on the size of a dark sector. We find that observation of an evaporating black hole at a distance of 0.01 parsecs could probe dark sector models containing one or more copies of the Standard Model particles, with any mass scale up to 100TeV.
Pairing instabilities of the Yukawa-SYK models with controlled fermion incoherence
Authors: Choi Wonjune , Tavakol Omid , Kim Yong Baek
Published: May 2022

The interplay of non-Fermi liquid and superconductivity born out of strong dynamical interactions is at the heart of the physics of unconventional superconductivity.
As a solvable platform of the strongly correlated superconductors, we study the pairing instabilities of the Yukawa-Sachdev-Ye-Kitaev (Yukawa-SYK) model, which describes spin-1/2 fermions coupled to bosons by the random, all-to-all, spin-independent and dependent Yukawa interactions.
In contrast to the previously studied models, the random Yukawa couplings are sampled from a collection of Gaussian ensembles whose variances follow a continuous distribution rather than being fixed to a constant.
By tuning the analytic behaviour of the distribution, we could control the fermion incoherence to systematically examine various normal states ranging from the Fermi liquid to non-Fermi liquids that are different from the conformal solution of the SYK model with a constant variance.
Using the linearised Eliashberg theory, we show that the onset of the unconventional spin-triplet pairing is preferred with the spin-dependent interactions while all pairing channels show instabilities with the spin-independent interactions.
Although the interactions shorten the lifetime of the fermions in the non-Fermi liquid, the same interactions also dress the bosons to strengthen the tendency to pair the incoherent fermions.
As a consequence, the onset temperature T_cTc of the pairing is enhanced in the non-Fermi liquid compared to the case of the Fermi liquid.
KAMPANYE LINTAS BUDAYA UNTUK MENGURANGI TINGKAT STRES PADA MAHASISWA PARUH WAKTU DI INGGRIS
Authors: Zahra Athaya
Published: May 2022

Contrary to numbers of labour markets in England, which have been increased presently, the mental health issue regarding work stress has become more threatening in the past fve years. Surprisingly, the dominant group is young ages between 18-29-years-old, particularly full-time students who have a part-time job or work. This circumstance is unfortunate, given the fact that young people are likely to be the key to drive the industry innovation forward. However, the core problem of this matter is current stress relief method that has been provided by a company or institution is probably less relevant to student’s culture and demands. In-depth research was conducted through secondary and primary studies, such as literature analysis; observation of DMU Mental Health Day event; online questionnaire of 50 DMU students; an interview with DMU Employability and Wellbeing staﬀ; interviews with 3 DMU Britain students, and a focus group involving East Asia students. As a result, key fndings were revealed, including: 1) 40 out of 44 DMU full-time students who have part-time job felt stressed due to working; 2) what young people need the most when they were stressed was a short break; 3) East Asia cultures have certain treatments which helped students to get relaxed; 4) students showed less interest in joining stress management services provided by the University and preferred to resolve the problem individually due to the fact that students believe it was their personal. Through this study, ESCAPE15, a social campaign prototype was designed to examine the eﬀectiveness of East Asian relief method in order to alleviate part-time student’s stres in England.
Prototipação de game educativo para prevenção de acidentes na infância
Authors: Costa Vânia Chagas da , Silva Keity Ranielly do Amaral , Felix Luana Ketlen Cavalcanti de Lima , Nascimento Monique Maria de Lima , Pereira Emanuela Batista Ferreira e
Published: May 2022

Objetivo: Descrever o desenvolvimento de um protótipo de game educativo para prevenção de acidentes comuns na infância. Metodologia: Estudo descritivo sobre desenvolvimento tecnológico de um protótipo de game educativo, proveniente de pesquisa original sobre utilização da gamificação como ferramenta educativa para prevenção de acidentes na infância. O desenvolvimento do protótipo guiou-se pela estratégia Design Thinking, com uso do software educacional Scratch que é uma plataforma online, gratuita. Os cenários e personagens foram construídos com figuras disponíveis em acesso livre na internet. Resultados: O protótipo do game foi intitulado “Detetives do perigo”, com público alvo crianças entre 8 a 10 anos de idade. As fases do game apresenta situações de risco de acidente na rotina diária da criança, e explica de forma simples e interativa como evitá-los. O game é composto por dez cenários, sendo quatro de orientações e seis dos ambientes domiciliar, escolar, via e parque público, onde são expostas as situações de risco de acidente. Conclusão: O uso de ferramentas tecnológicas nas ações de educação em saúde, permite que a criança seja protagonista no cuidado com sua saúde e bem-estar, o despertar do senso crítico compatível com sua faixa etária, pode contribuir na redução de acidentes na infância.  Descritores: Prevenção de acidentes, Saúde da criança, Jogos e brinquedos, Informática em enfermagem, Educação em saúde.
Hydrochemistry and stable isotopes in a coastal lagoon affected by evaporation, Cabo de Gata (Almería)
Authors: Sola Fernando , Pulido-Bosch Antonio , Vallejos Angela
Published: May 2022

The Salinas de Cabo de Gata are a natural coastal lagoon that has been anthropically transformed to favor the entry of seawater and its evaporation until saturation in sodium chloride. For this, it is compartmentalized in a series of ponds in which the seawater is guided by a circuit along which the salinity increases. Sediment samples have been taken at the bottom of these ponds and water samples to recognize which hydrogeochemical processes occur along the route. In the first ponds (evaporators) the suspended solids are decanted and carbonate precipitation occurs, along with the formation of pyrite linked to the high concentration of organic matter. On the other hand, in the last ponds (crystallizers) gypsum precipitation occurs when 70% evaporation is reached and, finally, halite when it reaches 90%. This precipitation notably changes the chemical composition of the waters, reducing the concentration of the ions present in the minerals that precipitate. From the isotopic point of view, gypsum precipitation also has its mark, reducing the proportions of 18O/16O and 2H/1H in the pond water. The study of these processes, in a mesoscale system, has great advantages for making palaeoenvironmental inferences at the basin scale, such as knowing what percentage of seawater must be evaporated so that gypsum or halite can precipitate in a basin.
Recent Advancement of Transition Metal-mediated Reactions of Diazomethane and (Trimethylsilyl)diazomethane
Authors: Muhuri Sanjukta
Published: May 2022

Diazomethane and trimethylsilyl diazomethane are common and versatile reagents in organic synthesis and they are unique as reactants in synthetic methodology. These reagents may be used in esterification, dipolar cycloaddition, epoxidation, aziridination, cyclopropanation, and carbonyl homologation. The lack of practical, scalable methods for the construction of cyclopropanes is a long-standing problem in industrial chemistry and diazomethane/ trimethylsilyl diazomethane has the potential to significantly reduce the cost of bringing new cyclopropane-bearing compounds to market. The transition metal-mediated reactions of diazomethane and trimethylsilyl diazomethane with alkenes, terminal alkynes and carbonyl compounds are being discussed in this article. The mechanism of different coupling, insertion and rearrangement reactions are also explored in this review article. The toxicity and explosive nature of diazomethane/ trimethylsilyl diazomethane are known to all, but concurrently, their efficacy and significant role as the reagents in synthetic transformation can’t be ignored. The untoward properties of diazomethane and trimethylsilyl diazomethane combined with its versatility, make the identification of safe protocols for its use. Considering the importance of these reagents, a concise review is needed. This article will highlight recent metalmediated reactions of diazomethane and trimethylsilyl diazomethane compounds that have been reported from 2000 until 2020.
Proteomics and Computational Analysis of Cytosolic Proteome of a Thermoacidophilic
Euryarchaeon, Picrophilus torridus
Authors: Goel Manisha , Singhal Neelja , Garg Anjali , Singh Nirpendra , Kumar Manish
Published: May 2022

Background:

Picrophilus torridus is a thermoacidophilic archaeon that thrives in an extremely
low pH (0-1) and high temperatures (50-60°C). Thus, it is a suitable organism to study microbial
genetics and metabolic adaptations to the extremely acidic and moderate thermal environment.

Objective:

In the present study we have conducted a global proteome analysis of P. torridus and
discerned the cytosolic proteome of P. torridus using gel-free, liquid chromatographymass spectrometry
(LC-MS/MS).

Methods:

The cytosolic proteins of P. torridus were extracted and identified using gel-free, LCMS/
MS. Gene Ontology-based pathway analysis and protein-protein interaction studies were performed
to understand the role of various cytosolic proteins in sustaining the thermoacidophilic environment.
Also, domain analysis of hypothetical/uncharacterized proteins was performed.

Results:

Using gel-free LC-MS/MS, 408 cytosolic proteins of P. torridus were identified, including
36 hypothetical/uncharacterized proteins. Thus, we could identify 26.58 % of the theoretical proteome
of P. torridus. The majority of the cytosolic proteins were observed to be multi-functional and
involved in activities related to microbial metabolism.

Conclusion:

Comparison with an earlier study that used gel-based LC-MS analysis to identify cytosolic
proteins of P. torridus revealed that gel-free LC-MS was better in identifying more number of
proteins and also, higher/lower molecular weight proteins. The findings of this study may contribute
to our understanding of the P. torridus proteome and serve as a foundation for future proteomic research
on other thermoacidophilic archaea.
Proteomics, Peptidomics and Transcriptomic Analysis of the Venom from
the Spider Macrothele yani (Mygalomorphae: Macrothelidae)
Authors: Zhao Yu , Yang Zi-Zhong , Gu Xiao-Liang , Wang Ying , Zhang Cheng-Gui , Wu Xiu-Mei , Xiao Huai , Yang Yin-He , Yang Da-Song , Yang Zhi-Bin
Published: May 2022

Background:

Spider venom show abundant diversity in both peptides and proteins,
which play essential roles in new drug development and agrochemistry. The venoms of Macrothele
yani species have strong toxicity on the victims.

Objective:

The purpose of this study is to comprehensively characterize the profile of venom proteins
and peptides of spider Macrothele yani mainly inhabiting Yunnan province, China.

Methods:

Using a combination of RNA sequencing of the venom glands and venom proteomics based
on Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (LC-ESI-MS/MS),
we provide the first overview of the peptides and proteins synthesized from Macrothele yani.

Results:

A total of 116 peptide sequences were analyzed, and 43 homologous proteins were
matched, of which 38.10% were toxin proteins. High-throughput sequencing by the HiSeq-2000 (Illumina),
followed by de novo assembly. As a result, 301,024 similar protein sequences were annotated
in the available databases. A total of 68 toxins-related sequences were identified, comparative
sequence analyses of these sequences indicated the presence of different types of enzymes and toxin-
like genes, including Acetylcholinesterase, Hyaluronidase, cysteine-rich secretory proteins
(CRISP), Astacin metalloprotease and other venom components.

Conclusion:

The venom of a spider is a very abundant resource in nature. They were analyzed to
determine their function in pathophysiology. Molecular templates with potential application value in
medical and biological fields were obtained by classifying and characterizing the presumed components
of spider venom of Macrothele yani, which laid a foundation for further study of the venom in
the future.
Evaluation of the In Vitro Antimicrobial Activities of Delphinium roylei: An Insight from Molecular Docking and MD-Simulation Studies
Authors: Mir Wajahat Rashid , Bhat Basharat Ahmad , Almilaibary Abdullah , Asdaq Syed Mohammed Basheeruddin , Mir Manzoor Ahmad
Published: May 2022

Ethnopharmacological relevance:

The burden of antimicrobial resistance demands a continued search for new antimicrobial drugs. The synthetic drugs used clinically have serious side effects. Natural products or compounds derived from natural sources show diversity in structure and play an essential role in drug discovery and development.

Objective:

Delphinium roylei is an important medicinal herb of Kashmir Himalaya, India. Traditionally this medicinal plant treats liver infections, skin problems, and chronic lower back pain. The current study evaluates the antimicrobial potential of various extracts by in -vitro and in -silico studies.

Methods:

Three extracts and 168 bioactive compounds analysed through LC-MS data, with the vast majority of them having therapeutic applications. D. roylei have been screened for the antimicrobial activity against bacteria (Escherichai coli, Streptococcus pneumonia, Haemophilus influenzae, Neisseria mucosa) and fungi (Candida albicans, Candida glabrata, Candida Paropsilosis) species through molecular docking using autodock Vina, MD simulation and a broth microdilution method for minimum inhibitory concentration (MIC) evaluation.

Results:

The extracts and the compounds analyzed through the LC-MS technique of Delphinium roylie showed significant antimicrobial activity.

Conclusion:

Our study established that the leaf extracts of Delphinium roylei exhibit antimicrobial activity and thus confirm its importance in traditional medicine.
A Review on PCR and POC-PCR - A Boon in the Diagnosis of COVID-19
Authors: Amuthalakshmi Sivaperuman , Sindhuja Singaravelan , Nalini Calambur Nagarajan
Published: May 2022

Ever since the global spread of covid 19, PCR predominantly took the lead in the diagnosis. It amplifies a particular DNA target sequence into millions of copies. To simplify the laboratory-dependent disease diagnosis, the point of care diagnostics (POC) paved the way for lab-on-a-chip-technology. Succeeding that, POC integrated with PCR stole the limelight. This review points out the various diagnostic methods of covid 19 based on PCR and POC-PCR along with its principles, and types clustered regularly interspaced short palindromic repeats (CRISPR) based assays for the rapid, accurate, and easier detection of covid 19.
Supra-therapeutic Anticoagulation with Warfarin: A Cross-sectional
Study
Authors: Sridharan Kannan , Banna Rashed Al , Husain Aysha
Published: May 2022

Aims:

To identify the extent and associated factors for patients with prolonged prothrombin
time, international normalized ratio (PT-INR), and the dosage modifications were carried
out with warfarin.

Background:

Studies evaluating patients on warfarin with supratherapeutic anticoagulation are
limited. It is vital to understand the management strategies for patients receiving warfarin who are
bleeding and those with only supratherapeutic PT-INR.

Objective:

To evaluate the factors associated with supratherapeutic anticoagulation without bleeding
with warfarin.

Methods:

A cross-sectional study was carried out on patients receiving long-term warfarin with at
least one PT-INR value > 3.2. Percent time in therapeutic range (TTR) was calculated and National
Institute for Health and Care Excellence (NICE) guidelines were adhered to defining anticoagulation
control into good (> 65%) and poor (< 65%).

Results:

One hundred and forty-four patients were recruited. Nearly half of the study population
had PT-INR values between 3.2 and 3.9. On average, individuals had at least 4 times PT-INR values
in the supratherapeutic range. Elderly patients were observed with a significant trend of supratherapeutic
INR. Duration of therapy was significantly correlated with the risk of PT-INR > 4.
Lower TTR was observed in patients with frequent PT-INR > 4 and those patients had significantly
poor anticoagulation control. Duration of warfarin therapy and HAS-BLED scores were observed
to be significant predictors of supratherapeutic INR. Large variations were observed in the modifications
of warfarin dose carried out at various supratherapeutic INR values and consequently PTINR
values.

Conclusion:

We observed that the majority of patients with supratherapeutic INR had their INR
values between 3.2 and 3.9. Elderly patients, with higher HAS-BLED scores and prolonged duration
of warfarin therapy, were observed with an increased risk of supratherapeutic anticoagulation.
Careful dosage modifications are needed particularly in high-risk categories as mentioned above.
Cellular and Molecular Aspects of Managing Familial Hypercholesterolemia: Recent and Emerging Therapeutic Approaches
Authors: Taheri Forough , Taghizadeh Eskandar , Baniamerian Fatemeh , Rostami Daryoush , Rozeian Ahmad , Mohammad Gheibi hayat Seyed , Jamialahmadi Tannaz , Reiner Željko , Sahebkar Amirhossein
Published: May 2022

Familial hypercholesterolemia (FH) as a high-frequency genetic disorder is diagnosed
based on family and/or patient’s history of coronary heart disease (CHD) or some other atherosclerotic
diseases, LDL-C levels, and/or clinical signs such as tendinous xanthoma, arcus cornealis
before age 45 years as well as a functional mutation in the LDLR, apoB or PCSK9 gene.
Its clinical features are detectable since early childhood. Early diagnosis and timely treatment
increase life expectancy in most patients with FH. Current FH therapies decrease the level of lowdensity
lipoprotein up to ≥50% from baseline with diet, pharmacotherapeutic treatment, lipid
apheresis, and liver transplantation. The cornerstone of medical therapy is the use of more potent
statins in higher doses, to which often ezetimibe has to be added, but some FH patients do not
achieve the target LDL-C with this therapy Therefore, besides these and the most recent but already
established therapeutic approaches including PCSK9 inhibitors, inclisiran, and bempedoic
acid, new therapies are on the horizon such as gene therapy, CRISPR/Cas9 strategy, etc. This
paper focuses on cellular and molecular potential strategies for the treatment of FH.
MISREPRESENTATION SEBAGAI FRAUD DALAM PERKARA KONTRAK ASURANSI YANG DILAKUKAN PENANGGUNG
Authors: Mulhadi Mulhadi , Harianto Dedi
Published: May 2022

Insurance companies in Indonesia are currently trapped in the stigma of seeking the highest premiums. Many agents do not work according to standards and do not explain in detail the insured party’s rights and obligations. This study aims to determine the meaning of misrepresentation and forms of misrepresentation made by the insurer in an insurance contract case based on court decisions. This normative juridical approach uses content analysis method. The results showed that the insurer failed to provide correct information about the importance of medical check-ups about life insurance, failed to explain the relationship between honesty in disclosing material circumstances with the risk of cancellation of the policy or the consequences of an insurance claim being rejected, failed to present the correct information to policyholders and gives the impression that insurance claims can be made easily, only with a photocopy of the receipt for payment of hospital fees, and the failed to present correct information that the policy can only be closed to other people if the prospective insured has a birth certificate and cannot be replaced by a statement only.
REKONSEPTUALISASI PRINSIP KEDAULATAN NEGARA DALAM PENANGGULANGAN BENCANA DI INDONESIA: LESSON FROM COVID-19
Authors: Puspita Natalia
Published: May 2022

In its application, the state’s primary responsibility principle is often challenged by the ability and the willingness of a country in overcoming various disasters that are massive such as the Covid-19 pandemic. This paper analyzes the importance of reconceptualizing of the state sovereignty principle in disaster management especially in Indonesia by learning from the Covid-19 response. This is a normative juridical research. This results shows that a state sovereignty in disaster conditions should be understood as a form of state responsibility to protect its people by welcoming an international cooperation in the form of humanitarian assistance when such a country is unable or unwilling to overcome. The condition of a strong or a weak government can be the most important benchmark for determining the acceptance of international assistance. This of course, can be a recommendation for the Indonesian government to stop the polemic of receiving or seeking international assistance related to the legal implications of establishing the status of a national disaster in Indonesia.
ASAS PERSONALITAS KEISLAMAN DALAM PENETAPAN ASAL-USUL ANAK LUAR KAWIN KE PENGADILAN NEGERI
Authors: Hartini Hartini
Published: May 2022

This research aims to analyze the choice of Muslims in choosing the District Court for filing cases of acknowledgment or ratification of illegitimate children against their biological father; examine the qualification of cases used in determining the civil relation between illegitimate children and their biological father; and examine the legal implications for Muslims who obtained a court ruling from the district court regarding the relationship of an illegitimate child to his biological father. This research is categorized as legal normative research that uses the Decision of District Courts as an analysis material. The results of the research show that based Islamic personality principle, the application for civil relation of an illegitimate child to the district Court is not entirely wrong as there is still an opportunity for broad interpretation of the post-Constitutional Court Decision when it is associated with population administrations. The cases that were proposed to the district courts were qualified as a child recognition child legitimacy cases. And this decision implies that there will be differences due to the law and and there is the potential to violate Islamic law, especially regarding the rights of illegitimate children to their fathers.
PENGARUH PENGGUNAAN MEDIA SOSIAL DAN LINGKUNGAN KELUARGA TERHADAP MINAT BERWIRAUSAHA PADA MAHASISWA FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA
Authors: Gustina Maria , Sumiati Ati , Mardi Mardi
Published: May 2022

Abstrak: Penelitian ini bertujuan untuk mengetahui Pengaruh Penggunaan Media Sosial dan Lingkungan Keluarga Terhadap Minat Berwirausaha Pada Mahasiswa Fakultas Ekonomi Universitas Negeri Jakarta. Metode yang digunakan adalah metode kuantitatif. Populasi terjangkau dalam penelitian ini adalah mahasiswa S1 di Fakultas Ekonomi UNJ angkatan 2018 yang berjumlah 269 orang dengan sampel sebanyak 161 orang menggunakan teknik proportional random sampling. Pengumpulan data menggunakan instrument kuesioner dengan skala likert. Uji persyaratan analisis yang dilakukan menujukkan hasil yakni data berdistribusi normal dan linear. Berdasarkan hasil uji hipotesis dan uji koefisien determinasi dapat disimpulkan bahwa semua hipotesis diterima. Koefisien determinasi pada penelitian ini adalah 46,7% yang menunjukkan penggunaan media sosial dan lingkungan keluarga dalam memengaruhi minat berwirausaha sedangkan sisanya dipengaruhi faktor lain yang tidak diteliti. Berdasarkan hasil analisis tersebut dapat disimpulkan bahwa Penggunaan Media Sosial dan Lingkungan Keluarga secara simultan berpengaruh terhadap Minat Berwirausaha.Abstract: This research was conducted on undergraduate students at the Faculty of Economics UNJ. The method used is the survey method with questionnaires. The affordable population in this study was undergraduate students at the Faculty of Economics unj class of 2018 which amounted to 269 people with a sample of 161 people using proportional random sampling techniques. The data analysis techniques used are descriptive analysis, analysis requirement test, hypothesis test, and determination coefficient test. The analysis requirements test conducted showed the results are normal and linear distributed data. Based on the results of hypothesis tests and coefficients of determination, it can be concluded that all hypotheses are accepted. The coefficient of determination in this study was 46.7% which showed the use of social media and family environment in influencing entrepreneurial interests while the rest was influenced by other factors that were not studied. Based on the results of the analysis, it can be concluded that the use of social media and family environment simultaneously affects entrepreneurial interests.
DAMPAK COVID-19 TERHADAP PENAWARAN DAN PENDAPATAN PEKERJA INFORMAL DAERAH ISTIMEWA YOGYAKARTA/IMPACT OF COVID-19 ON THE SUPPLY AND INCOME OF INFORMAL WORKERS IN THE SPECIAL REGION OF YOGYAKARTA
Authors: Murda Handani
Published: May 2022

Abstrak: Sektor ekonomi informal paling rentan terdampak Covid-19 sehingga penulis tertarik untuk meneliti dampaknya terhadap penawaran tenaga kerja dan pendapatan pekerja informal. Penelitian ini bertujuan untuk mengetahui dampak Covid-19 terhadap penawaran dan pendapatan pekerja informal di Daerah Istimewa Yogyakarta. Data yang digunakan dalam penelitian ini menggunakan mikro data sekunder Survei Angkatan Kerja Nasional (Sakernas) yang dikumpulkan Badan Pusat Statistik pada Agustus 2019 dan Agustus 2020. Analisis menggunakan model regresi simultan dengan variabel intrumental, teknik estimasi two stage least square (2 SLS) dan koreksi bias selektif. Penelitian membahas dampak pandemi Covid-19 dengan pendekatan analisis penawaran dan pendapatan pekerja informal. Pekerja  informl merespon cukup signifikan dampak pandemi terhadap penurunan penawaran dan pendapatan. Dampak pandemi terbesar dirasakan pekerja informal pada Sektor Non Pertanian, diikuti pekerja informal laki-laki dan pekerja informal yang tinggal di perkotaan.Abstract: The informal economy sector has been most vulnerable to being affected by Covid-19, so the authors are interested in examining its impact on the supply of labor and the income of informal workers. This study aims to determine the impact of Covid-19 on the supply and income of informal workers in the Special Region of Yogyakarta. The data used in this study uses secondary micro data from the National Labor Force Survey (Sakernas) collected by the Central Statistics Agency in August 2019 and August 2020. The analysis uses a simultaneous regression model with instrumental variables, two stage least square (2 SLS) estimation techniques and corrections. selective bias. The study discusses the impact of the Covid-19 pandemic with an approach to analysis of the supply and income of informal workers. Informal workers have responded significantly to the impact of the pandemic on declining supply and income. The greatest impact of the pandemic was felt by informal workers in the non-agricultural sector, followed by male informal workers and informal workers living in urban areas.
LITERASI KEUANGAN SYARIAH DAN PERILAKU MENABUNG MAHASISWA
Authors: Mustofa Mustofa
Published: May 2022

Abstrak: Penelitian ini bertujuan untuk mengetahui tingkat literasi keuangan syariah dan perilaku menabung mahasiswa. Penelitian ini merupakan penelitian survei. Metode penelitian yang digunakan merupakan deskriptif kuantitatif. Sampel yang diambil sejumlah 100 mahasiswa Fakultas Ekonomi Universitas Negeri Yogyakarta. Pengumpulan data menggunakan teknik angket/kuesioner. Hasil penelitian menunjukkan bahwa literasi keuangan syariah mahasiswa berada di level rendah yaitu not literate (32%) dan less literate (38%). Sedangkan sisanya berada di level sufficient literate (30%). Ditinjau dari perilaku menabung, mayoritas mahasiswa memiliki rekening di bank umum dan masih sedikit mahasiswa yang meiliki rekening bank syariah.Abstract: This study aims to determine the level of Islamic financial literacy and student saving behavior. This research is a survey research. The research method used is descriptive quantitative. The samples taken were 100 students of the Faculty of Economics, Yogyakarta State University. Data collection uses a questionnaire/questionnaire technique. The results showed that students' Islamic financial literacy was at a low level, namely not literate (32%) and less literate (38%). While the rest are at the sufficient literate level (30%). In terms of saving behavior, the majority of students have accounts at commercial banks and there are still a few students who have Islamic bank accounts.
FRONT MATTER (Cover, Editorial Team, Preface, Focus & Scope, Table of Contents)
Authors: - -
Published: May 2022

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Kinerja guru matematika SMP dalam membangun minat dan motivasi belajar siswa
Authors: Tambunan Hardi
Published: May 2022

Penelitian ini bertujuan untuk mendeskripsikan kinerja guru matematika SMP dalam membangun minat dan motivasi belajar siswa. Penelitian ini adalah penelitian ex post facto. Populasi mencakup semua siswa kelas 8 SMP di 4 sekolah negeri dan 3 sekolah swasta di Sumatera Utara, dan sampel diambil secara acak sebanyak 243 siswa. Instrumen penelitian menggunakan angket, dan data penelitian dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa secara umum kinerja guru matematika dalam membangun minat belajar siswa berada pada kategori cukup. Ketika membangun minat belajar siswa, dilihat dari aspek menyampaikan tujuan pembelajaran, menjelaskan manfaat pembelajaran, dan pendekatan pembelajaran yang digunakan, kinerja guru berada pada kategori cukup, sedangkan dalam hal membuat siswa senang belajar kinerja guru masih berada pada kategori kurang baik. Kinerja guru matematika dalam membangun motivasi belajar siswa juga berada pada kategori cukup. Ketika membangun motivasi belajar siswa, kinerja guru dalam menjelaskan pentingnya belajar keras, melaksanakan ujian remedial, memberitahukan hasil ujian, dan memberikan pujian berada pada kategori cukup, sedangkan kinerja dalam membuat kompetisi di kelas berada pada kategori kurang baik AbstractThis study aimed to describe junior high school mathematics teachers’ performance in building student interest and motivation. This study was an ex post facto research. The population included all eighth-grade students of junior high schools from four public schools and three private schools in Sumatera Utara, Indonesia, and 243 students were randomly selected as samples. The instrument used a questionnaire, and the data were analyzed descriptively. The results showed that, in general, mathematics teachers’ performance in building students’ interest in learning was in the moderate category. In building students’ interest in learning, teachers’ performance conveying learning objectives, explaining the benefits of learning, and the learning approach used, teachers’ performance was in the moderate category, while in terms of making students happy to learn, teacher performance was still in the poor category. The performance of mathematics teachers in building students’ motivation was also in the moderate category. In building students’ motivation, teachers’ performance in explaining the importance of studying hard, administrating remedial exams, notifying test results, and giving praise were in the moderate category, while making class competition is in the poor category.