bluuebunny/crossref_metadata_2025 huggingface dataset:
Accessing Low-Valent Titanium CCC-NHC Complexes: Toward Nitrogen Fixation
Authors: Dey Sriloy , Hollis T. Keith
Published: February 2021

The dramatic expansion of the earth’s population can be directly correlated with the Haber–Bosch process for nitrogen fixation becoming widely available after World War II. The ready availability of artificial fertilizer derived thereof dramatically improved food supplies world-wide. Recently, artificial nitrogen fixation surpassed the natural process. The Haber–Bosch process is extremely energy and green-house gas intensive due to its high-temperature and H2 demands. Many low valent Ti(II) complexes of N2 are known. We report herein a preliminary investigation of the low-valent chemistry of Ti with the CCC-NHC ligand architecture. These CCC-NHC pincer Ti(IV) complexes are readily reduced with KC8 or Mg powder. Preliminary results indicate very different reactivity patterns with alkynes and phosphines for this ligand architecture versus prior ligands. Successful reduction to an intact low-valent (CCC-NHC)Ti complex was confirmed by re-oxidation with PhICl2.
Adult Postabdomen, Immature Stages and Biology of Euryommatus mariae Roger, 1856 (Coleoptera: Curculionidae: Conoderinae), a Legendary Weevil in Europe
Authors: Gosik Rafał , Wanat Marek , Bidas Marek
Published: February 2021

The larva and pupa of the saproxylic Euryommatus mariae Roger, 1857, the weevil species extremely rare in Europe, are described from Poland. It was reared from galleries in dead branches of a fallen spruce Picea abies. The larval morphology is compared with available larval descriptions of other genera of the supertribe Conoderitae, namely, the Palaearctic Coryssomerus, and the Nearctic Cylindrocopturus and Eulechriopus. The specific characters of the male and female postabdomen are described and illustrated, expressing the peculiar structure of endophallus and spermathecal duct, not seen in any other weevil species. A hypothesis regarding the mechanics of mating in this species is proposed. Euryommatus mariae is recorded for the first time to occur in China.
Surgical Aortic Valve Replacement with Concomitant Aortic Surgery in Patients with Purely Bicuspid Aortic Valve and Associated Aortopathy
Authors: Çelik Mevlüt , Mahtab Edris A. F. , Bogers Ad J. J. C.
Published: February 2021

The bicuspid aortic valve (BAV) is the most common congenital cardiac malformation associated with aortopathy. The current study provides surgical clinical data on the patient characteristics and long-term survival of this less common adult purely BAV population undergoing surgical aortic valve replacement (SAVR) with concomitant aortic surgery. Adult patients with purely BAV who underwent SAVR and concomitant aortic surgery were included. Prevalence, predictors of survival, and outcomes for this patient population were analyzed. A total of 48 patients (mean age 58.7 ± 13.2 years, 33% female) with purely BAV underwent SAVR and concomitant aortic surgery between 1987 and 2016. The majority (62%) of the patients had pure aortic stenosis (AS). A total of 12 patients died. Survival was 92%, 73%, and 69% at 1, 5, and 20 years of follow-up. At 15 years of follow-up, the survival was close to that of the Dutch population, with a relative survival of 77%. Adult patients with a purely bicuspid aortic valve morphology undergoing SAVR and concomitant aortic root and/or ascending aorta present with excellent survival.
Preoperative Patient-Reported Outcomes in Suspected Low-Grade Glioma: Markers of Disease Severity and Correlations with Molecular Subtypes
Authors: Buvarp Dongni , Rydén Isabelle , Sunnerhagen Katharina S. , Olsson Bontell Thomas , Gómez Vecchio Tomás , Smits Anja , Jakola Asgeir Store
Published: February 2021

This prospective study aims to determine the overall health-related quality of life (HRQoL), functioning, fatigue, and psychological distress preoperatively in patients with suspected diffuse low-grade glioma (dLGG). We were particularly interested if these parameters differed by molecular tumor subtypes: oligodendroglioma, IDHmut astrocytoma and IDHwt astrocytoma. Fifty-one patients answered self-assessed questionnaires prior to operation (median age 51 years; range 19–75; 19 females [37%]). Thirty-five (69%) patients had IDH-mutated tumors, of which 17 were 1p/19q codeleted (i.e., oligodendroglioma) and 18 non-1p/19q codeleted (i.e., IDHmut astrocytoma). A lower overall generic HRQoL was associated with a high level of fatigue (rs = −0.49, p < 0.001), visual disorder (rs = −0.5, p < 0.001), motor dysfunction (rs = −0.51, p < 0.001), depression (rs = −0.54, p < 0.001), and reduced functioning. Nearly half of the patients reported high fatigue (23 out of 51 patients) and anxiety (26/51 patients). Patients with IDHwt had worse generic HRQoL, worse functioning, and more severe fatigue, though differences were not statistically significant between the molecular subtypes. In conclusion, fatigue and anxiety are prominent self-assessed symptoms of patients with suspected dLGG in a preoperative setting, but do not seem to be a reliable method to make assumptions of underlying biology or guide treatment decisions.
Feasibility of Coronary Artery Calcium Scoring on Dual-Energy Chest Computed Tomography: A Prospective Comparison with Electrocardiogram-Gated Calcium Score Computed Tomography
Authors: Lee Sun Yong , Kim Tae Hoon , Han Kyunghwa , Shin Jae Min , Kim Ji Young , Kim Daein , Park Chul Hwan
Published: February 2021

Rationale and Objectives: This study aimed to evaluate the feasibility of assessment using the coronary artery calcium score (CACS) in dual-energy chest computed tomography (CT). Materials and Methods: We prospectively enrolled 30 patients (19 male, 11 female; mean age, 63.73 ± 9.40 years) who clinically required contrast-enhanced chest CT. The patients underwent electrocardiogram-gated cardiac calcium-scoring CT with a slice thickness of 2.5 mm followed by a sequentially non-gated contrast-enhanced dual-energy chest CT using 140/80 fast kVp switching technology with slice thicknesses of 1.25 mm and 2.5 mm. Virtual unenhanced (VUE) images were then reconstructed from the dual-energy CT using the material suppressed iodine (MSI) technique. Results: The mean heart rates were 63.33 ± 12.01 beats per minute. The mean CACS on the coronary calcium-scoring CT was 361.1 ± 435.5, and CACSs of the VUE images were 76.8 ± 128.6 (2.5 mm slice) and 108.7 ± 165.1 (1.25 mm slice). The correlation coefficients of CACS between the coronary calcium-scoring CT with the VUE 2.5 mm and 1.25 mm images were 0.888 and 0.904, respectively. The inter-observer agreements for the calcium score measurement between the calcium-scoring CT, VUE 2.5 mm, and VUE 1.25 mm were 1.000, 0.999, and 1.000, respectively. Conclusions: In conclusion, assessment of CACS using dual-energy chest CT might be feasible when using MSI virtual unenhanced dual-energy chest CT images with a slice thickness of 1.25 mm.
New Surgical Technique for Robotic Myomectomy: Continuous Locking Suture on Myoma (LSOM) Technique
Authors: Lee Sa Ra , Lee Eun Sil , Eum Hye Rim , Lee Young-Jae , Lee Shin-Wha , Park Jeong Yeol , Suh Dae-Shik , Kim Dae-Yeon , Kim Sung Hoon , Kim Yong-Man , Kim Young-Tak
Published: February 2021

Robot-assisted laparoscopic myomectomy (RALM) has broadened the indications even in complex myomas. However, the high cost of RALM remains the main disadvantage. Therefore, a surgical technique that can reduce the cost of RALM and still has the advantages of robotic surgery is required. We propose a “locking suture on myoma (LSOM)” technique and compared the operative and perioperative outcomes of patients who underwent RALM with or without the LSOM technique. We included 337 patients who underwent RALM with (n = 160) or without (n = 177) the LSOM technique between March 2019 and August 2020. The LSOM group had low parity and gravidity, with a low rate of Cesarean sections. Myoma type was not different between the groups; however, patients in the LSOM group had larger, heavier, and higher number of myomas, although fewer patients had multiple myomas and were discharged earlier. Total operating time, estimated blood loss, pre- and postoperative hemoglobin levels, transfusion rate, and postoperative fever were not different between the two groups. In conclusion, the LSOM technique may be a viable surgical option for myomas, as it can reduce the cost of RALM by obviating the need for robotic Tenaculum forceps.
Randomised Controlled Trials of Alcohol-Based Surgical Site Skin Preparation for the Prevention of Surgical Site Infections: Systematic Review and Meta-Analysis
Authors: Peel Trisha N. , Watson Eliza , Lee Sue J.
Published: February 2021

(1) Background: Surgical site skin preparation is an important approach to prevent postoperative wound infections. International guidelines recommend that alcohol-based combinations be used, however, the optimal combination remains uncertain. This study compares the effectiveness of alcohol-based chlorhexidine and alcohol-based iodophor for surgical site skin preparation for prevention of surgical site infections (SSIs). (2) Methods: Randomised controlled trials comparing alcohol-based interventions for surgical site skin preparation were included. The proportion of SSIs was compared using risk ratios (RR) with 95% confidence intervals (95% CI). The meta-analysis was performed with a fixed effect model using Mantel-Haenszel methods. As an a priori subgroup analysis SSI risk was examined according to different surgical procedural groups. (3) Results: Thirteen studies were included (n = 6023 participants). The use of chlorhexidine-alcohol was associated with a reduction in risk of SSIs compared with iodophor-alcohol (RR 0.790; 95% CI 0.669, 0.932). On sub-group analysis, chlorhexidine-alcohol was associated with a reduction in SSIs in caesarean surgery (RR 0.614; 95% CI 0.453, 0.831) however, chlorhexidine-alcohol was associated with an increased risk of SSI in bone and joint surgery (RR 2.667; 95% CI 1.051, 6.765). When excluding studies at high risk of bias on sensitivity analysis, this difference in alcohol-based combinations for bone and joint surgery was no longer observed (RR 2.636; 95% CI 0.995, 6.983). (4) Conclusions: The use of chlorhexidine-alcohol skin preparations was associated with a reduced risk of SSI compared to iodophor-alcohol agents. However, the efficacy of alcohol-based preparation agents may differ according to the surgical procedure group. This difference must be interpreted with caution given the low number of studies and potential for bias, however, it warrants further investigation into the potential biological and clinical validity of these findings.
Non-Alcoholic Fatty Liver in Patients with Chylomicronemia
Authors: Maltais Mélanie , Brisson Diane , Gaudet Daniel
Published: February 2021

Non-alcoholic fatty liver disease (NAFLD) is frequent in patients with features of the metabolic syndrome (MetS), obesity, or type 2 diabetes. Lipoprotein lipase (LPL) is the main driver of triglyceride (TG) hydrolysis in chylomicrons and very-low density lipoproteins (VLDL). In some patients with MetS, dysfunction of this pathway can lead to plasma TG values > 10 mmol/L (multifactorial chylomicronemia or MCS). Chylomicronemia also characterizes LPL deficiency (LPLD), a rare autosomal recessive disease called familial chylomicronemia syndrome (FCS), which is associated with an increased risk of recurrent pancreatitis. This study aims to investigate the expression of NAFLD, as assessed by transient elastography, in MCS and FCS subjects. Data were obtained from 38 subjects with chylomicronemia; 19 genetically confirmed FCS and 19 sex- and age-matched MCS. All participants underwent liver ultrasonography and stiffness measurement after a 4-h fast using transient elastography (FibroScan®, Echosens, Waltham, MA, USA). NAFLD (controlled attenuation parameter (CAP) > 280 dB/m) was observed in 42.1% of FCS and 73.7% of MCS subjects (p = 0.05). FCS subjects had lower body mass index (BMI) than MCS. Only 25% of FCS subjects with NAFLD had a BMI ≥ 30 compared to 64.3% in MCS (p = 0.004). In FCS, NAFLD occurred even in the presence of very low (≤18 kg/m2) BMI. In both FCS and MCS, CAP was negatively associated with acute pancreatitis risk. In this study, NAFLD was commonly observed in both FCS and MCS subjects and occurred independently of the BMI and fasting glucose values in FCS; NAFLD was associated with a lower occurrence of acute pancreatitis episodes.
Management of Lupus Nephritis
Authors: Tamirou Farah , Houssiau Frédéric A.
Published: February 2021

Lupus nephritis (LN) is a frequent and severe manifestation of systemic lupus erythematosus. The main goal of the management of LN is to avoid chronic kidney disease (CKD). Current treatment strategies remain unsatisfactory in terms of complete renal response, prevention of relapses, CKD, and progression to end-stage kidney disease. To improve the prognosis of LN, recent data suggest that we should (i) modify our treat-to-target approach by including, in addition to a clinical target, a pathological target and (ii) switch from conventional sequential therapy to combination therapy. Here, we also review the results of recent controlled randomized trials.
Cerebral Anatomy Detection and Surgical Planning in Patients with Anterior Skull Base Meningiomas Using a Virtual Reality Technique
Authors: Zawy Alsofy Samer , Nakamura Makoto , Suleiman Ayman , Sakellaropoulou Ioanna , Welzel Saravia Heinz , Shalamberidze David , Salma Asem , Stroop Ralf
Published: February 2021

Anterior skull base meningiomas represent a wide cohort of tumors with different locations, extensions, configurations, and anatomical relationships. Diagnosis of these tumors and review of their therapies are inseparably connected with cranial imaging. We analyzed the influence of three-dimensional-virtual reality (3D-VR) reconstructions versus conventional computed tomography (CT) and magnetic resonance imaging (MRI) images (two-dimensional (2D) and screen 3D) on the identification of anatomical structures and on the surgical planning in patients with anterior skull base meningiomas. Medical files were retrospectively analyzed regarding patient- and disease-related data. Preoperative 2D-CT and 2D-MRI scans were retrospectively reconstructed to 3D-VR images and visualized via VR software to detect the characteristics of tumors. A questionnaire of experienced neurosurgeons evaluated the influence of the VR visualization technique on identification of tumor morphology and relevant anatomy and on surgical strategy. Thirty patients were included and 600 answer sheets were evaluated. The 3D-VR modality significantly influenced the detection of tumor-related anatomical structures (p = 0.002), recommended head positioning (p = 0.005), and surgical approach (p = 0.03). Therefore, the reconstruction of conventional preoperative 2D scans into 3D images and the spatial and anatomical presentation in VR models enabled greater understanding of anatomy and pathology, and thus influenced operation planning and strategy.
Modified Laparoscopic Transabdominal Cervicoisthmic Cerclage for the Surgical Management of Recurrent Pregnancy Loss due to Cervical Factors
Authors: Chung Hyewon , Lee Seungmee , Song Changho , Jang Tae-Kyu , Bae Jin-Gon , Kwon Sang-Hoon , Shin So-Jin , Cho Chi-Heum
Published: February 2021

This study aimed evaluate the feasibility of modified laparoscopic transabdominal cervicoisthmic cerclage (LTCC) and its impact on recurrent pregnancy loss (RPL) and is a retrospective observational cohort study of patients who underwent modified LTCC from 2003 to 2018 (n = 299). The surgery was performed at a mean gestational age of 12.5 weeks (range 10.5–17.5 weeks). Of the 299 patients, 190 were reported as having undergone abortion (one abortion: 91 (47.9%), two: 59 (31.1%), three or more: 40 (21.1%)) before the present pregnancy and prior to the surgery. The mean operation time was 47.4 min (range 15–100 min). We followed up with 205 of 299 patients and recorded their obstetric outcomes. There were 176 successful deliveries via cesarean section, and the fetal survival rate was 85.9% (176/205). The results of this study suggest that modified LTCC is a safe and feasible surgical option during pregnancy for patients with a history of RPL due to cervical factors.
Maternal Resources, Pregnancy Concerns, and Biological Factors Associated to Birth Weight and Psychological Health
Authors: Ramiro-Cortijo David , de la Calle María , Gila-Díaz Andrea , Moreno-Jiménez Bernardo , Martin-Cabrejas Maria A. , Arribas Silvia M. , Garrosa Eva
Published: February 2021

Cognitive maternal adaptation during pregnancy may influence biological variables, maternal psychological, and neonatal health. We hypothesized that pregnant women with numerous general resources and less negative emotions would have a better coping with a positive influence on neonatal birth weight and maternal psychological health. The study included 131 healthy pregnant women. A blood sample was obtained in the first trimester to assess biological variables (polyphenols, hematological and biochemical parameters). Psychological variables (negative affect, anxiety, optimism, resilience, family–work conflicts, pregnancy concerns, general resources, and life satisfaction) were evaluated at several time points along gestation, and birth weight was recorded. Hierarchical linear regression models were used to associate the above parameters with maternal psychological outcome at the end of gestation (depression, resilience, and optimism) and neonatal outcome (birth weight). Maternal depression was associated with leukocytes (β = 0.08 ± 0.03, p-value = 0.003), cholesterol (β = 0.01 ± 0.002, p-value = 0.026), and pregnancy concerns (β = 0.31 ± 0.09, p-value = 0.001). Maternal resilience was associated with leukocytes (β = −0.14 ± 0.09, p-value = 0.010) and life satisfaction (β = 0.82 ± 0.08, p-value = 0.001), and maternal optimism was associated with polyphenol levels (β = 0.002 ± 0.001, p-value = 0.018) and life satisfaction (β = 0.49 ± 0.04, p-value = 0.001). Birth weight was associated with maternal resilience (β = 370.2 ± 97.0, p-value = 0.001), red blood cells (β = 480.3 ± 144.4, p-value = 0.001), and life satisfaction (β = 423.3 ± 32.6, p-value = 0.001). We found associations between maternal psychological, blood variables, and birth weight and maternal depression. This study reveals the relevance of psychological health during pregnancy for maternal and neonatal outcome, and it emphasizes the need to consider it in preventive policies in the obstetric field.
Cytokine Profiles of Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy with Regards to Radiation Pneumonitis Severity
Authors: Jeong Bae Kwon , Kim Jin Hyun , Jung Myeong Hee , Kang Ki Mun , Lee Yun Hee
Published: February 2021

The immunologic aspects of radiation pneumonitis (RP) are unclear. We analyzed variations in cytokine profiles between patients with grade (Gr) 0–1 and Gr ≥ 2 RP. Fifteen patients undergoing concurrent chemoradiotherapy for non-small cell lung cancer were included. Blood samples of 9 patients with Gr 0–1 and 6 with Gr ≥ 2 RP were obtained from the Biobank. Cytokine levels were evaluated using an enzyme linked immunosorbent assay at before radiotherapy (RT) initiation, 1, 3, and 6 weeks post-RT initiation, and 1 month post-RT completion. Concentrations of granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-6, IL-10, IL-13, IL-17, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β were analyzed; none were related to the occurrence of Gr ≥ 2 RP at pre-RT initiation. At 3 weeks, relative changes in the G-CSF, IL-6, and IFN-γ levels differed significantly between the groups (p = 0.026, 0.05 and 0.026, respectively). One month post-RT completion, relative changes of IL-17 showed significant differences (p = 0.045); however, relative changes in TNF-α, IL-10, IL-13, and TGF-β, did not differ significantly. Evaluation of changes in IL-6, G-CSF, and IFN-γ at 3 weeks after RT initiation can identify patients pre-disposed to severe RP. The mechanism of variation in cytokine levels in relation to RP severity warrants further investigation.
The Liver Surface Is an Attractive Transplant Site for Pancreatic Islet Transplantation
Authors: Inagaki Akiko , Imura Takehiro , Nakamura Yasuhiro , Ohashi Kazuo , Goto Masafumi
Published: February 2021

In the current clinical islet transplantation, intraportal transplantation is regarded as the gold-standard procedure. However, in this procedure, 50 to 70% of the transplanted islets are immediately damaged due to a strong innate immune response based on islet–blood contact. We investigated the transplant efficiency of a novel method of liver surface transplantation using a syngeneic keratinocyte sheet to avoid islet–blood contact. To examine the influence of the keratinocyte sheet, substantial amounts of syngeneic islets (8 IEQs/g) were transplanted on the liver surface of diabetic rats, while marginal amounts of islets (4 IEQs/g) were transplanted via intraportal transplantation to compare the transplant efficiency. Blood glucose, intraperitoneal glucose tolerance, immunohistochemistry, and in vivo imaging findings of the cell sheet were evaluated. The study showed that islet transplantation to the liver surface immediately followed by a syngeneic keratinocyte sheet covering was effective for curing diabetic rats, while no rats were cured in the group without the cell sheet. Notably, islet grafts transplanted via this approach appeared to penetrate into the liver parenchyma. However, the transplant efficiency did not reach that of intraportal transplantation. Further refinements of this approach by introducing mesothelial or fibroblast cell sheets in combination with a preferable scaffold for islet grafts may help to improve the transplant efficiency.
Lifestyle and Psychological Factors of Women with Pregnancy Intentions Who Become Pregnant: Analysis of a Longitudinal Cohort of Australian Women
Authors: Hill Briony , Awoke Mamaru A. , Bergmeier Heidi , Moran Lisa J. , Mishra Gita D. , Skouteris Helen
Published: February 2021

Preconception lifestyle and psychological factors are associated with maternal and offspring outcomes. Both are important considerations for women planning pregnancy. The aim of this study was to explore associations between lifestyle/psychological factors and long-term pregnancy intentions in women who go on to become pregnant. Data from the cohort born 1973–1978 from the Australian Longitudinal Study of Women’s Health were utilised. Women were included if they had a new pregnancy occurring between Waves 3 and 5, resulting in 2203 women for analysis. Long-term pregnancy intentions (aspirations for children in 5–10 years), demographic, anthropometric, lifestyle (sedentary behaviour, physical activity, diet quality, smoking, alcohol use), and psychological factors (depression, anxiety, stress) were assessed at Wave 3. Multivariable logistic regression was employed to evaluate the associations between pregnancy intentions and lifestyle/psychological factors, adjusting for other explanatory variables. Younger age and being married were associated positively with pregnancy intentions, while living with obesity was associated negatively with pregnancy intentions. No lifestyle or psychological factors were significantly associated with pregnancy intentions. Our findings highlight potential opportunities to identify women who have longer-term pregnancy intentions during clinical care, offering a pivotal moment for preconception care relating to lifestyle health, psychological wellbeing, and family planning.
Marine Environmental Regionalization for the Beibu Gulf Based on a Physical-Biological Model
Authors: Pan Huanglei , Yu Xiaolong , Liu Dishi , Shi Dalin , Yang Shengyun , Pan Weiran
Published: February 2021

A physical–biological ocean model was employed to investigate characteristics of the Beibu Gulf in the northwest South China Sea (SCS) from 2011 to 2015. We adopted the spatially constrained multivariate clustering method to determine the refined marine environmental regionalization using 10 variables from the model output, and compared regionalization differences in ENSO (El Niño–Southern Oscillation) years. The simulated physical and biochemical variables display a wide spectrum of patterns in space and time. The regionalization maps indicated that the Qiongzhou Strait and its adjacent area can be classified as a separate region, characterized by the rich presence of nutrients, phytoplankton, zooplankton, and detritus, owing to the water invasion from the western Guangdong estuary. As a result of the invasive progression of the SCS, the northern and southern gulf show distinct features over a boundary near 20° N. In the La Niña year (2011), the classified boundary of the Qiongzhou Strait-northeastern gulf moved southwards due to enhanced phytoplankton growth. In the El Niño year (2015), the current collision from the northern gulf and SCS resulted in the boundary of the northern and southern gulf moving to approximately 19° N. These results provide useful guidance on subregional marine management and subregional studies for the gulf.
Proximate Chemical Composition of Dried Shrimp and Tilapia Waste Bioflocs Produced by Two Drying Methods
Authors: Binalshikh-Abubkr Tarq , Hanafiah Marlia M. , Das Simon Kumar
Published: February 2021

The effects of two waste sources, red hybrid tilapia (Oreochromis sp.) and whiteleg shrimp (Litopenaeus vannamei), and two drying methods (freeze-drying and oven-drying) on the proximate chemical composition of bioflocs were investigated. In total, four kinds of experimentally treated bioflocs were compared to identify the best waste source and drying method to produce biofloc of an acceptable nutrient value: freeze-dried shrimp biofloc (FDSBF), oven-dried shrimp biofloc (ODSBF), freeze-dried tilapia biofloc (FDTBF), and oven-dried tilapia biofloc (ODTBF). The protein, lipid, ash, fiber, total nitrogen free extract (NFE), and energy contents of the dried bioflocs ranged from 12.12 to 24.09 g/100 g, 0.35 to 0.92 g/100 g, 42.45 to 61.01 g/100 g, 7.43 to 17.11 g/100 g, 16.45 to 18.59 g/100 g, and 0.99 to 1.94 Kcal g−1, respectively. Statistically, there were significant differences within the means of the two biofloc sources in terms of their proximate compositions (p < 0.05). The average values between the drying methods for protein, lipid, total NFE, and energy were also significantly different, while no significant differences (p > 0.05) were recorded for ash and fiber. Amino acids (AAs) were higher in FDTBF, followed by ODTBF. The mineral profiles showed that phosphorous, potassium, manganese, selenium, and copper were higher in the tilapia waste bioflocs, while calcium, zinc, iron, copper, chromium, and cobalt were higher in the shrimp waste bioflocs. Although the statistical analysis showed that the shrimp waste bioflocs had higher levels of lipid, fiber, total NFE, and minerals, the tilapia waste bioflocs contained higher levels of potential AAs, energy, and protein, which are regarded as expensive ingredients in aquaculture feeding. This study indicates that biofloc derived from tilapia waste can be regarded as a more suitable source of biofloc meal (in terms of protein, ash, energy, and AAs) than biofloc derived from shrimp waste. Our findings also suggest that freeze-drying is a more effective drying method for drying biofloc, as it efficiently maintains nutritional quality.
Progress of the Oil Spill Risk Analysis (OSRA) Model and Its Applications
Authors: Ji Zhen-Gang , Li Zhen , Johnson Walter , Auad Guillermo
Published: February 2021

The Bureau of Ocean Energy Management (BOEM) is responsible for managing the development of US Outer Continental Shelf (OCS) energy and mineral resources. Because oil spills may occur from offshore oil and gas activities, BOEM conducts oil spill risk analysis (OSRA) prior to oil and gas lease sales. Since the 1970s, BOEM has developed and applied the OSRA model to evaluate the risk of potential oil spills to environmental resources. This paper summarizes some of the OSRA model progress and applications in the past decade: (1) calculation of the risk of catastrophic oil spills (with a volume over one million barrels), which concludes that the return period of a catastrophic oil spill in OCS areas is estimated to be 165 years; (2) a more efficient way to estimate the probability of oil spill contact to environmental resources in the Gulf of Mexico; (3) weathering calculations in OSRA, which enhances the accuracy of the OSRA model results; and (4) application of OSRA to the Ixtoc I oil spill as an example of how the OSRA model simulates large oil spills for oil spill preparedness and response.
Effectiveness Assessment of an Innovative Ejector Plant for Port Sediment Management
Authors: Pellegrini Marco , Aghakhani Arash , Gaeta Maria Gabriella , Archetti Renata , Guzzini Alessandro , Saccani Cesare
Published: February 2021

The need to remove deposited material from water basins is common and has been shared by many ports and channels since the earliest settlements along coasts and rivers. Dredging, the most widely used method to remove sediment deposits, is a reliable and wide-spread technology. Nevertheless, dredging is only able to restore the desired water depth but without any kind of impact on the causes of sedimentation and so it cannot guarantee navigability over time. Moreover, dredging operations have relevant environmental and economic issues. Therefore, there is a growing market demand for alternatives to sustainable technologies to dredging able to preserve navigability. This paper aims to evaluate the effectiveness of guaranteeing a minimum water depth over time at the port entrance at Marina of Cervia (Italy), wherein the first industrial scale ejector demo plant has been installed and operated from June 2019. The demo plant was designed to continuously remove the sediment that naturally settles in a certain area through the operation of the ejectors, which are submersible jet pumps. This paper focuses on a three-year analysis of bathymetries realized at the port inlet before and after ejector demo plant installation and correlates the bathymetric data with metocean data (waves and sea water level) collected in the same period. In particular, this paper analyses the relation between sea depth and sediment volume variation at the port inlet with ejector demo plant operation regimes. Results show that in the period from January to April 2020, which was also the period of full load operation of the demo plant, the water depth in the area of influence of the ejectors increased by 0.72 mm/day, while in the whole port inlet area a decrease of 0.95 mm/day was observed. Furthermore, in the same period of operation, the ejector demo plant’s impact on volume variation was estimated in a range of 245–750 m3.
Predictive and Preventive Mucosal Communications in Particulate Matter Exposure-Linked Renal Distress
Authors: Moon Yuseok
Published: February 2021

Despite research into the epidemiological link between exposure to particulate matter (PM) and renal disorder, there is limited information available on the etiological complexity and molecular mechanisms. Among the early responsive tissues to PM exposure, the mucosal barrier of the airway and alimentary tract may be a crucial source of pathologic mediators leading to inflammatory renal diseases, including chronic kidney disease (CKD). Given that harmful responses and products in mucosa exposed to PM may enter the circulation and cause adverse outcomes in the kidney, the aim of the present review was to address the impact of PM exposure on the mucosal barrier and the vicious feedback cycle in the mucosal environment. In addition to the PM-induced alteration of mucosal barrier integrity, the microbial community has a pivotal role in the xenobiotic metabolism and individual susceptibility to PM toxicity. The dysbiosis-induced deleterious metabolites of PM and nutrients are introduced systemically via a disrupted mucosal barrier, contributing to renal injuries and pathologic severity. In contrast, the progress of mucosa-associated renal disease is counteracted by endogenous protective responses in the mucosa. Along with direct elimination of the toxic mediators, modulators of the mucosal microbial community should provide a promising platform for mucosa-based personalized interventions against renal disorders caused by air pollution.
The Risk of Type 2 Diabetes Mellitus in a Russian Population Cohort According to Data from the HAPIEE Project
Authors: Mustafina Svetlana V. , Rymar Oksana D. , Shcherbakova Liliya V. , Verevkin Evgeniy G. , Pikhart Hynek , Sazonova Olga V. , Ragino Yuliya I. , Simonova Galina I. , Bobak Martin , Malyutina Sofia K. , Voevoda Mikhail I.
Published: February 2021

The aim of this study is to investigate the 14-year risk of type 2 diabetes mellitus (T2DM) and develop a risk score for T2DM in the Siberian cohort. A random population sample (males/females, 45–69 years old) was examined at baseline in 2003–2005 (Health, Alcohol, and Psychosocial Factors in Eastern Europe (HAPIEE) project, n = 9360, Novosibirsk) and re-examined in 2006–2008 and 2015–2017. After excluding those with baseline T2DM, the final analysis included 7739 participants. The risk of incident T2DM during a 14-year follow-up was analysed using Cox regression. In age-adjusted models, male and female hazard ratios (HR) of incident T2DM were 5.02 (95% CI 3.62; 6.96) and 5.13 (95% CI 3.56; 7.37) for BMI ≥ 25 kg/m2; 4.38 (3.37; 5.69) and 4.70 (0.27; 6.75) for abdominal obesity (AO); 3.31 (2.65; 4.14) and 3.61 (3.06; 4.27) for fasting hyperglycaemia (FHG); 2.34 (1.58; 3.49) and 3.27 (2.50; 4.26) for high triglyceride (TG); 2.25 (1.74; 2.91) and 2.82 (2.27; 3.49) for hypertension (HT); and 1.57 (1.14; 2.16) and 1.69 (1.38; 2.07) for family history of diabetes mellitus (DM). In addition, secondary education, low physical activity (PA), and history of cardiovascular disease (CVD) were also significantly associated with T2DM in females. A simple T2DM risk calculator was generated based on non-laboratory parameters. A scale with the best quality included waist circumference >95 cm, HT history, and family history of T2DM (area under the curve (AUC) = 0.71). The proposed 10-year risk score of T2DM represents a simple, non-invasive, and reliable tool for identifying individuals at a high risk of future T2DM.
German Farmers’ Perspectives on Price Drivers in Agricultural Land Rental Markets—A Combination of a Systematic Literature Review and Survey Results
Authors: von Hobe Cord-Friedrich , Michels Marius , Musshoff Oliver
Published: February 2021

Despite the popularity of agricultural land markets as a research topic, a current literature review on price drivers on agricultural land rental markets is missing, which is crucial in order to gain an overview of the status quo. Furthermore, farmers’ perceptions of price drivers on agricultural land rental markets have not been considered sufficiently. Therefore, this study combines descriptive results from a survey with 156 German farmers conducted during 2019–2020 using purposive sampling and a systematic literature review. The systematic literature review reveals four important areas acting as price drivers in agricultural land rental markets: policy/Common Agricultural Policy (CAP), bioenergy, climate change, and market prices/competition. Based on the overview, several points of departure for further research are provided. Furthermore, results from the survey show that farmers’ perceptions of the relative importance of the price drivers differ from the results of scientific literature. Therefore, perceptions of farmers should be considered for possible policy interventions derived from scientific evidence.
Analysis on the Effect of the Mobility of Combustion Vehicles in the Environment of Cities and the Improvement in Air Pollution in Europe: A Vision for the Awareness of Citizens and Policy Makers
Authors: Cárcel-Carrasco Javier , Pascual-Guillamón Manuel , Salas-Vicente Fidel
Published: February 2021

Today, the design and remodeling of urban environments is being sought in order to achieve green, healthy, and sustainable cities. The effect of air pollution in cities due to vehicle combustion gases is an important part of the problem. Due to the indirect effect caused by the Covid-19 pandemic, political powers in Europe have imposed confinement measures for citizens by imposing movement restrictions in large cities. This indirect measure has given us a laboratory to show how the reduction in vehicle circulation affects in a short time the levels of air pollution in cities. Therefore, this article analyzes the effect in different European cities such as Milan, Prague, Madrid, Paris, and London. These cities have been chosen due to their large amount of daily road traffic that generates high levels of pollution; therefore, it can clearly show the fall in these pollutants in the air in the analyzed period. The results shown through this study indicate that the reduction in combustion vehicles greatly affects the levels of pollution in different cities. In these periods of confinement, there was an improvement in air quality where pollutant values dropped to 80% compared to the previous year. This should serve to raise awareness among citizens and political powers to adopt measures that induce sustainable transport systems.
Systematic Review and Meta-Analysis of Wound Bundles in Emergency Midline Laparotomy Identifies That It Is Time for Improvement
Authors: Mc Geehan Gearóid , Edelduok Itoro M. , Bucholc Magda , Watson Angus , Bodnar Zsolt , Johnston Alison , Sugrue Michael
Published: February 2021

Background: Emergency midline laparotomy is the cornerstone of survival in patients with peritonitis. While bundling of care elements has been shown to optimize outcomes, this has focused on elective rather than emergency abdominal surgery. The aim of this study was to undertake a systematic review and meta-analysis of factors affecting the development of surgical site infection (SSI) in patients undergoing midline emergency laparotomy. Methods: An ethically approved, PROSPERO registered (ID: CRD42020193246) meta-analysis and systematic review, searching PubMed, Scopus, Web of Science and Cochrane Library electronic databases from January 2015 to June 2020 and adhering to PRISMA guidelines was undertaken. Search headings included “emergency surgery”, “laparotomy”, “surgical site infection”, “midline incision” and “wound bundle”. Suitable publications were graded using Methodological Index for Non-Randomised Studies (MINORS); papers scoring ≥16/24 were included for data analysis. The primary outcome in this study was SSI rates following the use of wound bundles. Secondary outcomes consisted of the effect of the individual interventions included in the bundles and the SSI rates for superficial and deep infections. Five studies focusing on closure techniques were grouped to assess their effect on SSI. Results: This study identified 1875 articles. A total of 58 were potentially suitable, and 11 were included after applying MINORS score. The final cohort included 2,856 patients from eight countries. Three papers came from the USA, two papers from Japan and the remainder from Denmark, England, Iran, Netherlands, Spain and Turkey. There was a 32% non-significant SSI reduction after the implementation of wound bundles (RR = 0.68; CI, 0.39–1.17; p = 0.16). In bundles used for technical closure the reduction in SSI of 15% was non-significant (RR = 0.85; CI, 0.57–1.26; p = 0.41). Analysis of an effective wound bundle was limited due to insufficient data. Conclusions: This study identified a significant deficit in the world literature relating to emergency laparotomy and wound outcome optimisation. Given the global burden of emergency general surgery urgent action is needed to assess bundle’s ability to potentially improve outcome after emergency laparotomy.
Author Response to Comment on: Dynamic Adsorption of Sulfamethoxazole from Aqueous Solution by Lignite Activated Coke
Authors: Li Haiyan , He Juan , Chen Kaiyu , Shi Zhou , Li Mengnan , Guo Pengpeng , Wu Liyuan
Published: February 2021

The authors would like to thank the comment by Diego M. Juela for contributing to helpful scientific discussions and correction suggestions, and to also express thanks to the editors.
Probabilistic Condition Monitoring of Azimuth Thrusters Based on Acceleration Measurements
Authors: Nikula Riku-Pekka , Ruusunen Mika , Keski-Rahkonen Joni , Saarinen Lars , Fagerholm Fredrik
Published: February 2021

Drill ships and offshore rigs use azimuth thrusters for propulsion, maneuvering and steering, attitude control and dynamic positioning activities. The versatile operating modes and the challenging marine environment create demand for flexible and practical condition monitoring solutions onboard. This study introduces a condition monitoring algorithm using acceleration and shaft speed data to detect anomalies that give information on the defects in the driveline components of the thrusters. Statistical features of vibration are predicted with linear regression models and the residuals are then monitored relative to multivariate normal distributions. The method includes an automated shaft speed selection approach that identifies the normal distributed operational areas from the training data based on the residuals. During monitoring, the squared Mahalanobis distance to the identified distributions is calculated in the defined shaft speed ranges, providing information on the thruster condition. The performance of the method was validated based on data from two operating thrusters and compared with reference classifiers. The results suggest that the method could detect changes in the condition of the thrusters during online monitoring. Moreover, it had high accuracy in the bearing condition related binary classification tests. In conclusion, the algorithm has practical properties that exhibit suitability for online application.
An Exploratory Approach to the Adoption Process of Bitcoin by Business Executives
Authors: Palos-Sanchez Pedro , Saura Jose Ramon , Ayestaran Raquel
Published: February 2021

The purpose of this research study is to analyze the exploratory study of the adoption of Bitcoin cryptocurrency based on blockchain technology and its use as a means of payment in companies. This research is exploratory in nature. As such, an adoption model was investigated using the technology acceptance model (TAM) which was extended with new variables. The sample was made up of business executives from companies and commercial establishments (n = 248). Partial least squares structural equation modeling (PLS-SEM) was chosen as the analysis and evaluation technique for the model. The authors demonstrated that privacy has an important influence on perceived utility, and that trust has a very significant influence on privacy and perceived ease of use, thus indirectly affecting the intention to use cryptocurrencies.
Accurate Prediction of Concentration Changes in Ozone as an Air Pollutant by Multiple Linear Regression and Artificial Neural Networks
Authors: Bekesiene Svajone , Meidute-Kavaliauskiene Ieva , Vasiliauskiene Vaida
Published: February 2021

This study considers the usage of multilinear regression and artificial neural network modelling to forecast ozone concentrations with regard to weather-related indicators (wind speed, wind direction, relative humidity and temperature). Initial data were obtained by measuring the meteorological parameters using the PC Radio Weather Station. Ozone concentrations near high-voltage lines were measured using RS1003 and at a 220 m distance using ML9811. Neural network models such as the multilayer perceptron and radial basis function neural networks were constructed. The prognostic capacities of the designed models were assessed by comparing the result data by way of the square of the coefficient of multiple correlations (R2) and mean square error (MSE) values. The number of hidden neurons was optimised by decreasing an error function that recorded the number of units in the hidden layers to the precision of the expanded networks. The neural software IBM SPSS 26v was used for artificial neural network (ANN) modelling. The study demonstrated that the linear regression modelling approach was lacking in its capacity to predict the investigated ozone concentrations by used parameters, whereas the use of an ANN offered more precise outcomes. The conducted tests’ results established the strength of the designed artificial neural network models with irrelevant differences between detected and forecasted data.
Path-Planning for Mobile Robots Using a Novel Variable-Length Differential Evolution Variant
Authors: Rodríguez-Molina Alejandro , Solís-Romero José , Villarreal-Cervantes Miguel Gabriel , Serrano-Pérez Omar , Flores-Caballero Geovanni
Published: February 2021

Mobile robots are currently exploited in various applications to enhance efficiency and reduce risks in hard activities for humans. The high autonomy in those systems is strongly related to the path-planning task. The path-planning problem is complex and requires in its formulation the adjustment of path elements that take the mobile robot from a start point to a target one at the lowest cost. Nevertheless, the identity or the number of the path elements to be adjusted is unknown; therefore, the human decision is necessary to determine this information reducing autonomy. Due to the above, this work conceives the path-planning as a Variable-Length-Vector optimization problem (VLV-OP) where both the number of variables (path elements) and their values must be determined. For this, a novel variant of Differential Evolution for Variable-Length-Vector optimization named VLV-DE is proposed to handle the path-planning VLV-OP for mobile robots. VLV-DE uses a population with solution vectors of different sizes adapted through a normalization procedure to allow interactions and determine the alternatives that better fit the problem. The effectiveness of this proposal is shown through the solution of the path-planning problem in complex scenarios. The results are contrasted with the well-known A* and the RRT*-Smart path-planning methods.
On Maximal Distance Energy
Authors: Sun Shaowei , Das Kinkar Chandra , Shang Yilun
Published: February 2021

Let G be a graph of order n. If the maximal connected subgraph of G has no cut vertex then it is called a block. If each block of graph G is a clique then G is called clique tree. The distance energy ED(G) of graph G is the sum of the absolute values of the eigenvalues of the distance matrix D(G). In this paper, we study the properties on the eigencomponents corresponding to the distance spectral radius of some special class of clique trees. Using this result we characterize a graph which gives the maximum distance spectral radius among all clique trees of order n with k cliques. From this result, we confirm a conjecture on the maximum distance energy, which was given in Lin et al. Linear Algebra Appl 467(2015) 29-39.
Surface Diffusion by Means of Stochastic Wave Functions. The Ballistic Regime
Authors: Torres-Miyares E. E. , Rojas-Lorenzo G. , Rubayo-Soneira J. , Miret-Artés S.
Published: February 2021

Stochastic wave function formalism is briefly introduced and applied to study the dynamics of open quantum systems; in particular, the diffusion of Xe atoms adsorbed on a Pt(111) surface. By starting from a Lindblad functional and within the microscopic Caldeira–Leggett model for linear dissipation, a stochastic differential equation (Ito^-type differential equation) is straightforwardly obtained. The so-called intermediate scattering function within the ballistic regime is obtained, which is observable in Helium spin echo experiments. An ideal two-dimensional gas has been observed in this regime, leading to this function behaving as a Gaussian function. The influence of surface–adsorbate interaction is also analyzed by using the potential of two interactions describing flat and corrugated surfaces. Very low surface coverages are considered and, therefore, the adsorbate–adsorbate interaction is safely neglected. Good agreement is observed when our numerical results are compared with the corresponding experimental results and previous standard Langevin simulations.