bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibacterial and antioxidant activities of lemon balm (Melissa officinalis L.) essential oil
Authors: Berechet Mariana Daniela , Simion Demetra , Stanca Maria , Alexe Cosmin Andrei , Constantinescu Rodica Roxana , Rapa Maria , Turcanu Andreea
Published: December 2020

Lemon balm (Melissa officinalis L.) belongs to the Lamiaceae family. Essential oil extracted from the aerial parts of lemon balm has been investigated for the protection of fruits during storage, as insecticidal, as well as in medicine, due to its bioactive properties. In this paper, the composition and identification of components from Melissa officinalis L. essential oil were determined by gas chromatography coupled with mass spectrophotometry (GC/MS) analysis. Total phenol content (TPC) and the scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl (DPPH·) and 2,2′-azino-bis (3-ethylbenzthiazoline)-6-sulfonic acid (ABTS+·) free radicals were evaluated by UV-VIS spectrometry. Antibacterial activities were carried out against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. Seventeen bioactive compounds were found as constituents of Melissa officinalis L. essential oil, among which o-cymene (19.735%), dehydro-p-cymene (17.180%), and limonene (11.589%) were found as the major components. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FT-IR) provided a confirmation for the chemical components of lemon balm essential oil identified by GC/MS. The values recorded for TPC and antioxidant activity were as follows: 54.72 mg GAE/g dry substance, 28.53% for DPPH, and 46.17% for ABTS assays, respectively. 100 µL lemon balm essential oil proved total antibacterial activity against the tested microorganisms. The results showed that the Melissa officinalis L. may be a good candidate as plant-derived antioxidant and antibacterial agent for medical footwear, wound dressings and other medical applications.
Special effect finish for bookbinding leather
Authors: Niculescu Olga , Gaidau Carmen , Badea Elena , Miu Lucretia , Gurau Dana , Simion Demetra
Published: December 2020

The art of bookbinding requires not only skills in the old craft of bookbinding but also materials that can transform a simple book into a high-quality artistic product. Due to its unique properties, leather still remains the first-choice material in the case of art and archival bindings. However, the long-term durability of modern leather is not known since there is little commercial interest in long periods of durability and the market of leather for art, design and archival purposes is very small. It is worth noting that deterioration is influenced by the manufacturing technology, and especially by the chemical ingredients used in the various steps of leather making, from dehairing to tanning and finishing. It is therefore very likely that modern and contemporary artworks made of/with modern leather undergo faster degradation than ancient and medieval artworks. Thus, leather finishing is very important for both artistic and sustainable points of view. In fact, finishes with special effects such as antique, bicolour, printed, cracked, waxy are highly sought for vegetable tanned leather used for artistic and luxury bookbinding, archival bookbinding and restoration purposes. The evolving leather finishing technology of chrome-free leather (i.e. vegetable tanned leather) has enabled us to protect and improve the quality, look and feel of leather and to make it suitable for contemporary art bindery.
New nanostructured composite obtained by innovative technologies
Authors: Simion Demetra , Gaidau Carmen , Ma Jianzhong , Wenbo Zhang
Published: December 2020

The paper is focused on obtaining a new nanostructured composite by innovative technologies based on: fibrillar cellulose/titanium dioxide/surfactants (bolaform- dodecandioyl-diglycine and surfactant classic-collagen hydrolysate)/ethanol/water, for improved surface properties. Innovation consists in technologies for obtaining new nanostructured composites, solubilisation/compatibilisation of their component substances for the conditioning of supports processed with the film created by evaporation of the emulsion nanocomposites. Fibrillar cellulose/titanium dioxide nanocomposites have been stabilized with bolaform surfactants in a 1:1 ratio of ethanol/water solvents in order to increase the uniformity of titanium dioxide shell nanocomposites. Nanostructured “cauliflower”-like composites developed as a result of biopolymer-surfactant interactions for fibrillar cellulose/titanium dioxide/bolaform couple in ethanol/water system are reported by SEM microscopy. The analysis by FTIR-ATR spectroscopy of bolaform, fibrillar cellulose and dynamic light scattering of 2 types of nanocomposites emulsions (with bolaform and classic surfactant emulsions) were reported. The new nanocomposites could provide the hybrid film with increased mechanical resistance to water and heat. Supports processing with the composite film improve wet/dry friction resistance, water resistance and tensile strength. Environmentally-friendly supports with smart multifunctional features are obtained for various applications.
The influence of alkaline extraction on some keratin hydrolysates properties
Authors: Berechet Mariana Daniela , Simion Demetra , Stanca Maria , Chelaru Ciprian , Alexe Cosmin-Andrei , Rapa Maria
Published: December 2020

Keratin is a fibrous protein abundant in nature, being the component of wool, hair, hooves, horns, feathers, and claws. Keratin is one of the most valuable natural biopolymers due to its chemical versatility and biological performance. At the molecular level, keratin is distinguished from other biopolymers by its high concentration of cysteine-containing sulfur. Two keratin hydrolysate batches were obtained in alkaline medium, at a constant concentration of 8% NaOH and 75°C (KerNa875), 85°C (KerNa885), and 95°C (KerNa895), and at a fixed temperature of 99°C and different concentrations of NaOH, i.e. 3% (KerNa399), 5% (KerNa599), and 8% (KerNa899), respectively. Physical-chemical analyses showed that the protein content ranging between 83.60% for KerNa875 and 88.88% for KerNa399, while the total nitrogen was found 13.83% and 14.67% in the case of KerNa875 and KerNa399, respectively. Dynamic light scattering analysis showed that the particle sizes decreased with the increased concentration in the reaction medium. The average particle size was between 1352 nm and 1771 nm for the samples obtained at a temperature of 99°C and with lower values between 463.3 nm and 571.6 nm for the samples obtained with 8% NaOH. The Fourier transform infrared (FT-IR) spectra evidenced the specific bands of keratin-specific proteins and sulfur compounds. Experiments were also performed to evaluate the antioxidant activity and the growth of Tamino and Mirastar wheat plants by applying the treatments with 3% and 5% concentrations of KerNa899 on wheat seeds. These experiments showed an improvement in the wheat plant growth during 10 days of observation compared to control sample. The results recommend the potential use for keratin hydrolysates in the medical, pharmaceutical, cosmetics fields, and also as fertilizers in agriculture.
Quality management and footwear value chain. A case study of Fibalco
Authors: Luca Alexandra , Iovan Dragomir Alina
Published: December 2020

In the complicated economic context, will survive only companies who can obtain recognizable products, with higher quality and who are economically efficient by reducing losses of any kind. An example of good practices is represented by SC Fibalco SRL, a footwear company from Craiova, Romania, which emphasizes the development strategy of the Quality Management and the value chain analysis. Fibalco's success is explained by the fact that the value chain analysis is a component of the quality management and the responsibility is distributed pyramidally starting from each employee to the top management. One of the chains in Fibalco's value chain is Industrialization of the new product, which is an element of originality and makes the difference between the theoretical and the practical approaches from the perspective of launching a new product on the market. Due to the Industrialization of the new product chain, in order to make it efficiently reproducible, many risks of failure are eliminated from the design phase, especially those related to the technical execution of the product. The result is a "clean" footwear product with clear lines without unnecessary sophistication. This paper demonstrates that the implementation of quality management and a complex value chain adapted to the company needs leads to brand value and loyalty among consumers.
The impact of supply chain integration on operational performance through resilience under COVID-19 pandemic
Authors: Barakat Mahmoud , Ali Ahmed , Abdelbary Islam , Haroun Mai
Published: December 2020

COVID-19 has now unleashed a global supply chain crisis across a huge number of organizations, stemming from a lack of understanding and flexibility of the multiple layers of their global supply chains. In addition to the lack of efficient management through unpredicted events and occasions. Drawing on extended resources based view and resilience theory, this paper attempts to shed the light on the mediating role of resilience between supply chain integration and organizational performance represented in quality, cost and delivery performance during the COVID-19 pandemic. 224 questionnaires were collected and analyzed through process macro technique proposed by Andrew Hayes to test the mediating role of resilience. The results indicated that resilience can significantly mediate the relationship between supply chain integration and quality, cost and delivery performance. Therefore, this paper contributes to both extended resources based view and resilience theory. As it empathize on how organizations can acquire a unique bundle of resources through integration, which will allow them to maintain a desirable level of performance during market disruption through building resilience. The results will practically guide organizations to invest in building resilience in order to be able to cope with unexpected events that disrupts the business environment such as COVID19.
Collagen hydrolysate from chromed shavings for leather finish
Authors: Kubilius Karolis , Valeikiene Violeta , Valeika Virgilijus
Published: December 2020

Chrome shavings are posing a pollution threat. An alkali-enzymatic hydrolysis method was utilized to get collagen hydrolysate (CH) as possible constituent for leather finishing formulations. The new enzyme preparation Vilzim PRO Conc was exploited for the hydrolysis. The dependence of CH properties on conditions of hydrolysis was explored. The direct addition 5% CH into finishing compositions increases tensile strength and relative elongation of films obtained from the compositions. Further increase of the collagen hydrolysate content in the films leads to worse mechanical properties of the films.
Circular product design assessment applied to clothing products
Authors: Olaru Sabina , Badea Ionela
Published: December 2020

One of the major Strategic Innovation Theme and corresponding Research Priority for the next years is Circular Economy and Resource Efficiency, according to Euratex. Recently, the European Commission launched the new "Industrial Strategy for a globally competitive, green and digital Europe", that will help deliver on three key priorities: maintaining European industry's global competitiveness and a level playing field, at home and globally, making Europe climate-neutral by 2050 and shaping Europe's digital future. In this context, innovation and market potential of the European textile and clothing industry involve the frequent use of the terms “Circular Economy”. Forward, the sector will operate according to a globalised and efficient circular economic model which maximises the use of local resources, exploits advanced manufacturing techniques and engages in cross-sectorial collaborations and strategic clusters. Although the benefits of the circular economy are fairly well understood, in reality there are few industrial examples of companies that have implemented a circular economy paradigm. Circular product design provides long-term sustainability performance for products, by applying the principle of "designing out waste". This paper presents the application of circular product design assessment for clothing, by using two practical tools to assess products' circularity: HotSpot Mapping and Circularity Calculator (developed by Delft University of Technology, Netherlands). Generally, clothing products need major redesign to fit the circular economy, so it is essential to assess the potential of the various circular strategies such as Reuse, Repair, Remanufacture and Recycle.
REWEART - A 100% real circular economy manufacturing process for vegan-organic-recycled footwear
Authors: Pantazi-Bajenaru Mirela , Parreno Enrique Montiel , Foiasi Traian , Gurau Dana
Published: December 2020

The negative impact on the environment caused by the current production of over 23,000 million pairs of shoes each year, either due to the consumption of huge quantities of raw materials or due to the thousands of tons of waste generated, is a sufficient reason to conceive a new type of shoe making process. The predominant manufacturing methods and the many components that the shoe contains make it impossible to recycle, due to the high complexity involved in separating materials. Once they reach the end of their life cycle, they inevitably end up in a landfill, generating a large amount of waste. REWEART is a footwear manufacturing project that is capable of producing sustainable goods based on a circular economy, co-financed by the European Commission through the LIFE program. REWEART aims to make vegan shoes with accessories made from recycled and organic materials, with 90% less energy and almost zero waste. REWEART wants to provide a tool to avoid the generation of waste in footwear consumption and to offer the footwear industry an alternative model of circular production to reduce energy consumption and to stop the destructive and unsustainable production of footwear.
Development of elasto-plastic eco-nano-materials for the footwear industry
Authors: Stelescu Maria Daniela , Constantin Daniela Ioana , Sonmez Maria , Alexandrescu Laurentia , Nituica Mihaela , Georgescu Mihai
Published: December 2020

The paper refers to the obtaining of new types of eco-nano elasto-plastic materials with high-performance characteristics based on ethylene-propylene-terpolymer rubber (EPDM), high-density polyethylene (HDPE), plasticized starch and organically modified montmorillonite (OMMT). The new materials were obtained by the technique of dynamic vulcanization and melt intercalation in a Plasti-Corder Brabender internal mixer, at 80 rpm and a temperature of 170°C. The influence of using the OMMT type nanofiller and the plasticized starch filler on the characteristics was observed. The new materials have a melt flow index of over 12g/10 min at 180°C for a force of 10 kg, which allows injection processing - an ecological method of processing polymeric materials. The samples show very good physical-mechanical characteristics both in the normal state and after accelerated aging at 168 hours at 170°C (tensile strength over 16 N/ mm2, tear strength over 102 N/mm, hardness 55-59°ShD, elasticity over 30%, etc.). The materials show high values of abrasion resistance (below 30 mm3), and very good results for mass and volume variation after 22 hours at 23°C in: water, acids and concentrated bases. These characteristics are due both to the composition of the new materials and to the obtaining technology. For evaluating the structural modification, analysis of the FT-IR spectral of the samples was carried out. The new materials can be used in different fields such as: in the footwear industry (soles, heels and plates), safety equipment (boots, etc), obtaining gaskets, hoses, technical rubber products for cars etc.
Effects of UV, humidity, and high temperature exposure on linen fibers
Authors: Sandulache Irina , Lite Mihaela-Cristina , Secareanu Lucia-Oana , Mitran Elena-Cornelia , Iordache Ovidiu , Perdum Elena
Published: December 2020

Generally, the most common damaging factors for linen textile materials are the environmental conditions, their handling, and natural decay. Such environmental factors are ultraviolet (UV) radiation, humidity, and high temperature. Therefore, to investigate the effects these factors may cause, an accelerated weathering test was conducted on linen fabrics, using alternating cycles of UV exposure and humidity, along with relatively high temperatures. The effects of this test were investigated using non-destructive and micro-destructive analysis techniques. Scanning Electron Microscopy (SEM) was used to observe any modifications appearing at the surface of the fibers. Energy Dispersive X-Ray Analysis (EDS) was employed in conjunction with SEM for obtaining the spectrum of the chemical elements that were present at the surface of the linen samples. The modifications of functional groups occurring due to the weathering of linen were assessed by Fourier-Transform Infrared Spectroscopy (FT-IR). The color change of the samples was measured with a spectrophotometer. All the acquired information can be used as a starting point for the development of customized environmental parameters for keeping patrimony linen fabrics in museums in optimum conditions, thus preventing further damage. Additionally, the artificially weathered fabrics will be further employed in conservation experiments as substitute for old linen fabrics.
Protocol for identification and assessment of natural and synthetic textile fibers
Authors: Secareanu Lucia-Oana , Sandulache Irina-Mariana , Mitran Elena-Cornelia , Lite Mihaela-Cristina , Apostol Adrian Alexandru , Iordache Ovidiu , Perdum Elena
Published: December 2020

Proper identification of textile materials is essential, as people use textiles for clothing and shelter, dental and medical devices, protective firefighting, or even military clothing. There have been several developments regarding fiber identification using instruments such as Fourier transform infrared spectroscopy, Raman spectroscopy, or electron microscopy. However, the traditional methods are prevalent as they are the cheapest alternative. In the present paperwork, an accelerated weathering test was conducted on two different textile materials – cotton (natural fiber) and polypropylene (synthetic fiber). Alternating cycles of UV exposure, along with humidity and relatively high temperatures were employed for the weathering test. In order to evaluate the degradation degree of the two fibers, the results were compared and investigated using non-destructive and micro-destructive analysis techniques such as Scanning Electron Microscopy (SEM), to evaluate the surface modifications of the fibers, and colorimetry, to quantify the color changes. In addition, Fourier-Transform Infrared Spectroscopy (FT-IR) indicated the modifications of functional groups that occurred after the weathering test. A non-destructive technique – X-Ray Diffraction (XRD) was also performed to obtain information about the crystalline structure. The obtained information will be used for cultural heritage studies.
Investigation of energy resources and gas discoveries in the Eastern Mediterranean region: the case of people’s expectations and social impacts in Egypt
Authors: Hammad Mahmoud A. , Mlaker Kac Sonja , Haddad Sandra S. G. , El Rouby Habiba S.
Published: December 2020

This study discusses the expected social impacts due to the recent offshore gas findings and development in the Eastern Mediterranean region on human communities in Alexandrian in the North of Egypt. A sample of 401 respondents of ordinary people who are living in the Alexandria governorate were sampled for the study using a convenience non-random sampling approach. The study showed most people are somewhat familiar with the ongoing gas discoveries in the Mediterranean Sea. The study also revealed that the people in Egypt have relatively high expectations from these gas discoveries. The ordinary people in Egypt expected that such discoveries of gas would have many positive and negative social impacts side by side. They expected several social benefits of gas finds such as: the contribution to the diversification of the economy, infrastructural development, expanding social services, improvement of the standard of living, business and investment opportunities, employment.
Chromatic assessment of newly manufactured leather and parchment for museum purposes
Authors: Miu Lucretia , Giurginca Mariana , Caniola Iulia-Maria , Micu Maria-Cristina , Paunescu Simona-Maria , Sendrea Claudiu , Badea Elena
Published: December 2020

Cultural heritage represents a national treasure evolving from the culture and spirituality of people. Therefore, it must be continuously recovered, protected and developed by all generations as priceless heritage. Referring to the Romanian cultural heritage items that are placed in restoration, at present, some works have been done for partial or complete replacing of degraded materials, both as the result of ageing under atmospheric and biologic agents. The aim of this study is testing different samples of new leather and parchment under UV radiation in the 220-380nm domain, in order to simulate the accelerated destruction in photo-oxidative conditions. The following materials have been studied: book binding leather obtained from calf hide, tanned by different systems (vegetable or vegetable and chromium) and parchment obtained from different kinds of animals. The evolution of the chromatic characteristics (luminosity, shade and chroma) at different exposure time was quantified by the diffuse reflectance technique in visible domain range and CIE-Lab software. Based on the chromatic stability after UV exposure, the most stable types of leather and parchment have been selected for further applications in the restoration process of historical manuscripts and books' covers.
PENGARUH PENGAWET BEKU (CRYOPRESERVATION) TERHADAP KADAR EPIDERMAL GROWTH FACTOR (EGF) PADA SELAPUT AMNION
Authors: S Ety Retno , Effendi Gunawan , Suhendro Gatut , Handojo I.
Published: December 2020

to measure the difference of EgF concentration in between fresh amniotic membranes and with cryopreservation in 16 amnioticmembranes. Each amniotic membrane was divided into two parts. the first part was extracted in fresh forms and the second partunderwent cryopreservation with glycerol 50% and was stored at –80° C during 1 month before extraction. Both parts of the membranewere extracted using ultrasonic disintegrator and concentration of EgF was measured from the obtained extract using ELISA method.the average concentration of EgF in the fresh amniotic membrane was 122.76 ± 11.59 pg/g while the average concentration of EgFin the amniotic membrane underwent cryopreservation was 99.34 ± 9.49 pg/g. Average degradation of EgF concentration due tocryopreservation is 18.49% ± 10.20%. EgF concentration in fresh amniotic membrane is significantly higher than the EgF concentrationin amniotic membrane underwent cryopreservation (p = 0.000). Degradation of EgF concentration due to cryopreservation at 95%fidence interval is 12.33% to 24.66%
MASALAH KETAHANAN (RESISTENSI) VANCOMYCIN TERHADAP ENTEROCOCCI
Authors: AN Urhayana Sennang
Published: December 2020

Enterococcus adalah bakteri komensal dalam usus (colon) manusia dan binatang, dapat menyebabkan infeksi saluran kemih,endokarditis dan infeksi intra abdominal. Vancomycin-resistant enterococci (VRE) merupakan masalah kesehatan utama di berbagainegara. VRE yang merupakan cadangan (reservoir) glycopeptide resistance dianggap dapat menjangkit ke manusia melalui persentuhan(kontak) dengan binatang atau memakan (konsumsi) daging. Walaupun E. faecalis lebih sering terjadi infeksi di manusia, tetapivancomycin resistance lebih sering ditemui di isolat E. faecium. VRE merupakan patogen pada populasi imunokompromis terutamapenderita yang mendapatkan berbagai antibiotik dan menjalani rawat inap yang lama. terdapat enam tipe glycopeptide resistanceyang dilaporkan mengenai enterococcus yaitu VanA, VanB, VanC, VanD, VanE dan Vang. VRE merupakan salah satu penyebab infeksinosokomial dan kerentanannya (kemampuan resistensinya) dapat berpindah antar organisme atau spesies lainnya. Untuk itu kebijakanpengendalian infeksi (infection control) dan panduan pemberian antibiotik sangat penting diterapkan untuk mengendalikan penyebaranVRE dan organism yang rentan (resisten) terhadap berbagai obat.
CORRELATION BETWEEN IFN-É¤ LEVELS, CHEST RADIOGRAPHY AND THE POSITIVITY OF SMEAR SPUTUM IN NEW TB CASES AT THE DR.SOETOMO HOSPITAL
Authors: Puspitasari Yessy , Nugraha Jusak
Published: December 2020

Tuberculosis is an infectious disease attacking lungs, triggering damage, and pulmonary dysfunction. Host cytokine responses will influence tuberculosis manifestations. The main host immune response is cellular immunity, and Delayed-Type Hypersensitivity (DTH). IFN-Î³ produced by Th-1, is a major cytokine acting to eliminate TB bacteria through macrophage activation. Chest radiography has an important value for the diagnosis of TB, especially in negative sputum smears. Radiological manifestations depend on several factors including host prior to TB exposure, age, and immune status. Sputum smear is also important in diagnosing, and assessing response to treatment of adult pulmonary TB. A cross-sectional study, comprising a total of 36 new pulmonary TB cases at the Dr.Soetomo Hospital who met the inclusion, and exclusion criteria, were establish. Plasma IFN-Î³ was examined by ELISA. Chest radiography was divided into three categories based on the National Tuberculosis Association of USA. Sputum smear data were taken from medical records. There were significant correlations between IFN-Î³ plasma levels with chest radiography (r= 0.365; Ï=0.029), IFN-Î³ with positive sputum smear (r= 0.447; Ï=0.006), positive sputum smear with chest radiography (r=0.674; Ï=0.001) IFN-Î³ plasma levels could reflect lesion area on chest radiography, and sputum smear positivity. IFN-Î³ plasma levels, chest radigraphy, and sputum positivity may reflect a Th-1immune response, so the more severe level of diseases, an immune response Th-1 become more activated.
Identification of Risk Factors Characteristics of Transfusion Reaction
Authors: Rahajeng Eko Putri , Samad Raehana , Muhiddin Rachmawati
Published: December 2020

Blood transfusion is an important part of health care. A blood transfusion can be carried out after careful consideration of its risks and benefits. One of the important considerations for blood transfusion is adverse transfusion reaction. Several risk factors for a transfusion reaction are age, gender, repeated transfusion, disease diagnosis, type of blood component, and blood incompatibility. This research is a descriptive study performed at Blood Bank Dr. Wahidin Sudirohusodo Hospital, Makassar, from January to December 2017. The subjects were all patients reported to have an acute transfusion, totaling 104 subjects. The descriptive method was carried out by the calculation of frequency distribution. From January to December 2017, 104 patients with transfusion reactions were obtained, predominantly were male (53.8%), with the lowest age range of â‰¥ 60 years (27.9%), packed red cell as the most found blood components (82.4%), a history of previous transfusion reactions (72.1%), and a diagnosis of malignancy (53.9%). The history of repeated transfusions is the most common risk factor compared to age, gender, blood component, and patient diagnosis.
Prevalence of Expanded Dengue Syndrome in Patients with Dengue Virus Infection at the Dr. Soetomo Hospital Surabaya in 2017 – 2018
Authors: Adissadah Avina Fimas , Aryati Aryati , Pusarawati Suhintam
Published: December 2020

Dengue Fever (DF) or Dengue Hemorrhagic Fever (DHF) is one of the infectious diseases that attracts much global attention, especially Indonesia because it impacts the mortality rate of the people in the world if adequate treatment is not given. Expanded Dengue Syndrome (EDS) is a clinical manifestation involving several organs such as lungs, liver, kidney, heart, and brain-related to dengue infections, with or without plasma leakage. This study aimed to determine the prevalence of expanded dengue syndrome in patients with dengue virus infection at the Dr. Soetomo Hospital in 2017–2018. Based on its purpose, the sampling technique used in this study was the total sampling of patients with DVI who admitted to Dr. Soetomo Hospital Surabaya. Every pediatric and adult patient who met the criteria were included in this study until a certain period in 2017–2018.  After the data collection, only thirty samples of EDS from the 196 sample data were collected. Thirty patients with expanded dengue syndrome had a manifestation of different organs. Such as: neurological, cardiac, respiratory system, gastro-hepatic, and kidneys. The laboratory test results showed that most platelet counts of 51,000 – 100,000 were found in seventeen patients, while the range of hemoglobin and hematocrit was normal. From a total of thirty samples of dengue virus infection patients with EDS, there were only eighteen patients who did a serological test. The most found serological results were (+/-) anti-dengue IgM and (+) anti-dengue IgG (40%).
Diagnostic Performance of Serum (1,3) Î²-D Glucan to Detect Fungal Infection in Acute Leukemia Patients with Chemotherapy
Authors: Wirastuti Dian Ariani , Sidharta B. Rina A , Suparto Yuwono Hadi , Saptawati Leli
Published: December 2020

Chemotherapy is a predisposing factor for infection in patients with malignancy, while culture, as the gold standard,limits the diagnosis of fungal infections. (1,3) Î²-D glucans, the most abundant polysaccharide component of the fungal wall,are increased in patients with Invasive Fungal Infections (IFI). This research was an analytical observational study with across-sectional approach involving 60 acute leukemia patients who received chemotherapy with suspicion of fungalinfection at the General Hospital of Dr. Moewardi, Surakarta, from September to October 2019. Fungal blood cultures andserum (1,3) Î²-D glucan levels by the enzyme-linked immunoassay method were examined. Diagnostic tests were performedto determine sensitivity, specificity, Positive Predict Value (PPV), Negative Predict Value (NPV), Positive Likehood Ratio (PLR),Negative Likehood Ratio (NLR), and the serum's accuracy value (1,3) Î²-D glucan levels to fungal culture. Most (88.3%) ofpatients were diagnosed with Acute Lymphocytic Leukemia (ALL), maintenance chemotherapy phase (51.3%), risk factorsfor neutropenia (50%), and intravenous (IV) line use (56.7%). Serum (1,3) Î²-D glucan levels in patients with positive fungalcultures (4) in blood samples had a median of 482.87 (476.13-640.56) pg/mL, while patients with negative fungal cultures(56) had a mean±SD 298,68±114,39 pg/mL. Diagnostic test with a cut-off of 471,717 pg/mL showed sensitivity of 100.0%,specificity of 96.4%, NPV of 100%, PLR of 28.00, and NLR of 0.00 with an Area Under Curve (AUC) value of 0.982 andCoefficient Interval (CI) 95% (0.950-1.014). The measurement of serum (1,3) Î²-D glucan at a cut-off value of 471,717 pg/mLshowed good performance as a biomarker for diagnosing and screening IFIs.
Immunophenotyping Pattern in Childhood Acute Leukemia in the Adam Malik Hospital Medan
Authors: Tampubolon Putri Chadijah , Lubis Bidasari , Aman Adi Koesoema , Nasution Malayana R
Published: December 2020

Leukemia is the most common malignancy at the age of under 15 years, with a ratio of 1 to 3 cancer cases in children.Immunophenotyping will improve accuracy and easily provide data reproducibility. To determine the immunophenotypingpattern in patients with acute leukemia in the Pediatric Center at the Adam Malik General Hospital, Medan. This research wasa cross-sectional study in children suffering from acute leukemia in the Pediatric Unit Adam Malik General Hospital, Medanbased on CBC, peripheral smear, bone marrow morphology, and flow cytometry immunophenotyping. Samples wereevaluated for blast morphologic and immunophenotyping was carried out. Results of morphologic observation andimmunophenotyping were compared. From 20 samples using the monoclonal antibody with flow cytometryimmunophenotyping, concordance with morphology is good (Îº = 0.886). After classification, the percentage of acuteleukemia was 45% B-ALL, 35% AML, and 20% T-ALL. One of 10 samples morphologically classified as ALL but reported asAML. Immunophenotyping has been shown to increase diagnostic accuracy and assist in establishing lines in blast cells,which was initially merely based on morphological features.
The Suitability of Compatibility Test Results with Gel Method between Diagnostic Grifols Gel Coombs and Diamed-Identification
Authors: Sianturi Tigor Pandapotan , Tambunan Betty Agustina
Published: December 2020

A compatibility test as part of a pre-transfusion test is mandatory to ensure blood compatibility between patients anddonors. Diamed-ID as the first gel-based product is commonly used as a reference for the compatibility test. The presence ofnew products such as DG Gel Coombs encourages research to compare them with reference methods. This study aimed toanalyze the suitability of DG Gel Coombs to Diamed-ID in the compatibility test with the same sample. This cross-sectionalanalytic observational study was conducted during November 2017-February 2018 at the Blood Transfusion Unit Dr.Soetomo Hospital, Surabaya using blood samples (n=40), which met the inclusion and exclusion criteria. Simultaneoustesting of the two products was according to the manufacturing requirements of each product (using different LISS reagentsfor red blood cell suspensions and centrifugation arrangements). The suitability of results was tested with Cohen's kappaand significant differences with McNemar. There was a minimum suitability of DG Gel Coombs to Diamed-ID for majorcompatibility tests, Îº 0.307 (95% CI: -0.029-0.643), significance 0.007 (p < 0.05) and moderate for minor, Îº 0,678 (95% CI:0.454-0.903), significance <0.0001 (p < 0.05). McNemar's significance was 0.016 (p < 0.05) for major compatibility test and0.031 (p < 0.05) for minor. Referring to Diamed-ID's results, false negatives were found on DG Gel Coombs for majorcompatibility tests (n=7) and minor (n=6). The suitability of results from DG Gel Coombs and Diamed-ID is not strong forcompatibility testing.
Correlation between Percentage of Reticulated Platelets and Heart Score in Patients with Suspected Non-ST Elevation Acute Coronary Syndromes
Authors: Mulyadi Fransisca , Prihatni Delita , Rita Coriejati , Turbawaty Dewi Kartika , Astuti Astri
Published: December 2020

Thrombus formation in non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) causes increased plateletconsumption, leading to a 20-fold increase of Reticulated Platelets (RP) release. Reticulated platelets have more granulesand proteins that make them quickly forming thrombus than mature platelets, potent to form bigger thrombus, andincrease the risk of Major Adverse Cardiac Events (MACE). HEART score is a risk stratification for possible NSTE-ACS, whichcan predict MACE. The study aimed to analyze the correlation between the percentage of reticulated platelets and HEARTscore. This research was a correlation observational cross-sectional study performed in Dr. Hasan Sadikin Hospital,Bandung, from August 2018 to May 2019. The subjects were patients suspected with NSTE-ACS by clinicians in theEmergency Department of Dr. Hasan Sadikin Hospital. These subjects were assessed for the HEART score andRP percentage. This study involved 52 subjects consisting of a higher number of males (76.9%) aged 45-64 years old (69.2%).HEART score stratification in this study was mostly high risk (69.2%), but none was low risk. Mean of platelet count, absolute3 3 RP, and RP percentage were 271±73 x103/mm , 9.3±4.3 x 103/mm , and 3.6±1.7%, respectively. The correlation testbetween RP percentage and HEART score with a 95% confidence interval using Spearman's correlation test showed asignificant positive correlation with moderate strength (p < 0.001 and r=0.475). The percentage of RP in this study was in thenormal range. However, there was a significant positive correlation with moderate strength between the percentage of RPand HEART scores in patients with suspected non-ST elevation acute coronary syndrome.
Методы соосаждения тяжелых металлов в сточных водах гальванического производства
ионами магния и кальция морской воды
Authors:   В.Н. Волкова, С.Б. Кунденок, Д.В. Волков
Published: December 2020

Рассматриваются экспериментальные методы реагентной очистки от примесей гальванического производства, основанные на осаждении ионов магния и кальция из морской воды в присутствии гидроксида натрия и соли алюминия. Рассмотрено влияние различных реагентов на процесс коагуляции примесей и скорости седиментации хлопьев. На основе полученных авторами экспериментальных данных разработан метод очистки стоков для судостроительного предприятия, позволяющий сократить время отстаивания сточных вод, а также затраты на реагенты.

Авторами проведен ряд лабораторных экспериментов по соосаждению тяжелых металлов в сточных водах гальванического производства разными методами, результаты позволили разработать собственный метод, сокращающий затраты на реагенты. Для оптимизации количества экспериментов применены методы теории вероятности и математической статистики. Получено уравнение регрессии в безразмерном масштабе относительно времени с параметрами аппроксимации результатов компьютерного моделирования. Модель показывает образование флокул во времени.
Ключевые слова: гальванические стоки, реагентная обработка с морской водой, моделирование процесса коагуляции
Sorption of Zinc by exopolysaccharides produced by liquid media of phytopatogenic fungi
Authors: VALENZUELA-COBOS JUAN DIEGO , GRIJALVA-ENDARA ANA
Published: December 2020

Phytopathogenic fungi such as: Colletotrichum gloeosporioides and Rhizopus stolonifer were cultivated in three different liquid culture media: LCC (glucose 40 g L-1 , yeast extract 3 g L-1 ), LC2 (glucose 40 g L-1 , yeast extract 3 g L-1 and tryptone peptone 2 g L-1 ) and LC3 (glucose 40 g L-1 , yeast extract 3 g L-1 and tryptone peptone 10 g L-1 ) under pH of 5.5 for the production of mycelial biomass and exopolysaccharides (EPS). The liquid culture medium (LC3) used in cultivation of Colletotrichum gloeosporioides showed the highest production of biomass (15.40 g L-1 ) and exopolysaccharides (3.40 g L-1 ). Exopolysaccharides (EPS) obtained from the liquid culture medium (LC3) of Colletotrichum gloeosporioides presented the highest absorption content of Zinc (56 mg g-1 ). The results presented that the exopolysaccharides (EPS) produced by Colletotrichum gloeosporioides showed the greatest biosorbent capacity of Zinc (Zn) using the culture medium with the highest amount of tryptone peptone.
Efficiency of modified radical mastectomy in the therapeutic conduct of breast cancer
Authors: MOISIN ANDREI , MANDA GEORGE , BRATU DAN GIORGIAN , SERBAN DRAGOS , SMARANDACHE CATALIN GABRIEL , MOTOFEI CATALINA , TĂNĂSESCU CIPRIAN
Published: December 2020

Breast cancer is the most common form of malignant tumour in females, its frequency being constantly increasing and being the second cause of mortality, after lung cancer, in women. The objective of the study is to evaluate the efficacy, performance and safety of modified radical mastectomy in clinical and technical terms in patients with breast cancer. Method and Results: A 5 year retrospective study was performed on the patients who underwent surgery for breast cancer. Of the 129 patients aged between 20 and 99 years, the maximum incidence is observed in the age group 60-69 years. The most used surgical procedures were: modified radical mastectomy (MRM) in 48 cases and sectorectomy in 32 cases. Madden type of MRM was performed in 95.83%, with no major intra or postoperative complications. Conclusions: Modified radical mastectomy is the first-choice surgery for patients diagnosed with breast cancer in more advanced stages of this disease, compared to conservative therapy which is indicated in the early stages of the disease. Active prophylaxis of surgical site infections was extremely important to achieve good cosmetic results of the surgical wound.
Clinical and microbiological features of carious dentin in immature permanent molars
Authors: VACARU RALUCA-PAULA , PER SILVIA , STANCIU IOANA-ANDREEA , MUNTEANU ANETA , MIRICESCU DANIELA , TOTAN ALEXANDRA , TĂNASE MIHAELA , DIDILESCU ANDREEA CRISTIANA
Published: December 2020

The present study aimed to assess the dentin lesion activity in non-superficial carious lesions affecting vital immature permanent molars and to investigate possible associations between microbiological status, clinical dentin alterations, and salivary cortisol levels. Study sample consisted of a total number of 22 immature permanent molars of 13 children. After clinical estimation of lesion activity, a fine sample of deep dentin layer was removed and inoculated on bacteria tests. Salivary cortisol was assessed using an ELISA method. Most molars were diagnosed as actively carious progressing. There was a gradual increase in the bacterial counts, with higher lactobacilli (p=0.001) and mutans streptococci (p=0.045) loads in deep carious lesions, without any salivary cortisol level association. The findings of the present study discriminate between different clinical characteristics of carious lesions, supporting a conservative cavity preparation approach.
Theory of Social Quality as a Tool for Analyzing Social Processes: Opportunities and Scope of Adaptation
Authors: Samsonov Vsevolod V.
Published: December 2020

The paper considers modern approaches to the study of social dynamics, which are conceptually reflected in theories of social quality of life, linking economic and statistical data with indicators reflecting integrative relationships and forms of social interaction. An attempt to assess the effectiveness of these theoretical and methodological approaches is carried out in the context of analyzing such a problem in Russian society as the increased level of emigration in recent years.
A Note on Migration Perturbation and Convergence Rates to a Steady State
Authors: Blume Lawrence Edward , Lukina Aleksandra Andreevna
Published: December 2020

Using tools developed in the Markov chains literature, we study convergence times in the Leslie population model in the short and middle run. Assuming that the population is in a steady-state and reproduces itself period after period, we address the following question: how long will it take to get back to the steady-state if the population distribution vector was affected by some shock as, for instance, the “brain drain”? We provide lower and upper bounds for the time required to reach a given distance from the steady-state.
Accuracy of magnetic resonance imaging for meniscal body tear in anterior cruciate ligament-deficient knees compared to anterior cruciate ligament-intact knee
Authors: Joshi Amit , Singh Nagmani , Basukala Bibek , Bista Rohit , Tripathi Navin , Pradhan Ishor
Published: December 2020

Objectives:

This prospective case–control study was conducted with primary aim to compare the value of magnetic resonance imaging (MRI) in terms of accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for the detection of meniscal tear in anterior cruciate ligament (ACL)-deficient and ACL-intact groups. The secondary aim was to identify if the sensitivity and accuracy differ if the MRI is older than 3 months from the time of surgery.

Materials and Methods:

There were 255 patients enrolled into this study out of which 207 fulfilled the inclusion criteria. Among 207, 138 underwent surgery within 1 month of MRI, 30 had 1–3 months delay, and 39 cases underwent surgery more than 3 months after their MRI. Among 167 patients who underwent surgery within 3 months of MRI, 97 had ACL tear and 71 had intact ACL.

Results:

The overall sensitivity for lateral meniscus tear (68.2%) is significantly lower than the medial meniscus tear (92.9%). The sensitivity of MRI for medial meniscus tear in ACL-deficient knee is lower than ACL-intact knees (90% vs. 96.2%, P = 0.3). Similarly, the sensitivity is significantly lesser for lateral meniscus tear in ACL-deficient knee compared to ACL-intact knee (50% vs. 83.3%, P = 0.009). The sensitivity of MRI for both the lateral and medial meniscus tear decreased if the MRI performed 3 months before the surgery.

Conclusion:

Patients with ACL-deficient knee have to be counseled for intraoperative detection of lateral meniscus tear as the sensitivity of MRI for lateral meniscus tear in ACL-deficient group is low. Similarly, if the MRI is more than 3 months old from the time of surgery, we recommend to repeat the MRI as the sensitivity decreases significantly.
VALENTYN MOROZ: HISTORIAN, WRITER AND DISSIDENT
Authors: Lenartovych Oleh
Published: December 2020

Formulation of the problem. The purpose of writing this article was the need to commemorate the memory of Valentyn Yakovych Moroz, a Volyn man, a political prisoner, an active participant in the dissident movement on the first anniversary of his death. He was the author of more than 100 works, a doctor of humanities at Jersey State College, a member of the «Slovo» association of Ukrainian Writers, and an honorary citizen of Volyn since 2017. He has dedicated his entire life fighting against totalitarianism. He died on April 16, 2019 in Lviv. He was buried in Lychakiv cemetery. The methodological basis of this research is a set of general scientific, interdisciplinary, historical and source methods, in particular: historicism, objectivity, historical-comparative, alternative, analysis and synthesis, etc. Their use allows us to recreate the process of forming the political views of V. Moroz, the reasons for the transformation of his consciousness in the direction of dissent, an uncompromising position on the Soviet totalitarian system against which he devoted his own life. The state of scientific study of the problem. The dissident movement is of great interest to Ukrainian historians. The first investigations were published in the mid-1990s. Among the authors are G. Kasianov, V. Baran, and B. Zakharov, who focused on the participation of the Ukrainian intelligentsia in the resistance movement. In the early 2000s, dissident movement research centers appeared that published their own intelligence, distributed memoirs and self-published literature, and recorded and published interviews with dissidents. In these works, V. Moroz was mentioned as one of the many authors of illegal literature, political prisoner managed to emigrate abroad. Sometimes there is conflicting information about the terms of his sentences. The only monograph dedicated to V. Moroz was personally published in 2018 by O. Poliansky. Due to the small circulation, it is difficult for the general public to get acquainted with it. Therefore, in our opinion, the intelligence proposed by the author is relevant and is designed to honor the memory of the extraordinary personality of who was V. Moroz.
POLISH WOMEN WHO DARED TO BE FIRST – PARTICULAR EXAMPLES
Authors: Słowiński Przemysław
Published: December 2020

The article presents Polish women living in the past centuries as well as those currently taking up challenges, whose goal was the implementation of tasks reserved only for men due to different legal, social, moral and other constraints. Through the presented examples of monarchs, scientists, prime ministers, etc., there are shown the cases of overcoming cultural barriers in the history of Poland to gender equality achieving.