bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of inter-hemispheric connections in functional brain networks
Authors: Martínez J. H. , Buldú J. M. , Papo D. , Fallani F. De Vico , Chavez M.
Published: July 2018

Today the human brain can be modeled as a graph where nodes represent different regions and links stand for statistical interactions between their activities as recorded by different neuroimaging techniques. Empirical studies have lead to the hypothesis that brain functions rely on the coordination of a scattered mosaic of functionally specialized brain regions (modules or sub-networks), forming a web-like structure of coordinated assemblies (a network of networks. NoN). The study of brain dynamics would therefore benefit from an inspection of how functional sub-networks interact between them. In this paper, we model the brain as an interconnected system composed of two specific sub-networks, the left (L) and right (R) hemispheres, which compete with each other for centrality, a topological measure of importance in a networked system. Specifically, we considered functional scalp EEG networks (SEN) derived from high-density electroencephalographic (EEG) recordings and investigated how node centrality is shaped by interhemispheric connections. Our results show that the distribution of centrality strongly depends on the number of functional connections between hemispheres and the way these connections are distributed. Additionally, we investigated the consequences of node failure on hemispherical centrality, and showed how the abundance of inter-hemispheric links favors the functional balance of centrality distribution between the hemispheres.
Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma
Authors: Henderson James M. , Polak Natasa , Chen Jinbiao , Roediger Ben , Weninger Wolfgang , Kench James G. , McCaughan Geoffrey W. , Zhang Hui Emma , Gorrell Mark D.
Published: July 2018

The urgent unmet need for hepatocellular carcinoma (HCC) therapies is addressed here by characterising a novel mouse model of HCC in the context of ongoing liver damage and overnutrition. Male C57Bl/6J mice were treated with diethylnitrosamine (DEN) and thioacetamide (TAA), and some were provided with an atherogenic high fat diet (HFD). Inflammation, steatosis, fibrosis, 87 genes, liver lesions and intratumoural leukocyte subsets were quantified up to 24 weeks of age. Adding HFD to DEN/TAA increased fibrosis, steatosis and inflammation, and the incidence of both HCC and non-HCC dysplastic lesions. All lesions contained α-SMA positive fibroblasts. Macrophage marker F4/80 was not significantly different between treatment groups, but the macrophage-associated genes Arg-1 and Cd47 were differentially expressed. Fibrosis, cancer and cell death associated genes were upregulated in DEN/TAA/HFD livers. Fewer Kupffer cells and plasmacytoid dendritic cells were in tumours compared to control liver. In conclusion, combining a hepatotoxin with an atherogenic diet produced more intrahepatic tumours, dysplastic lesions and fibrosis compared to hepatotoxin alone. This new HCC model provides a relatively rapid means of examining primary HCC and potential therapies in the context of multiple hepatotoxins including those derived from overnutrition.
Climate-driven shifts in algal-bacterial interaction of high-mountain lakes in two years spanning a decade
Authors: González-Olalla Juan Manuel , Medina-Sánchez Juan Manuel , Lozano Ismael L. , Villar-Argaiz Manuel , Carrillo Presentación
Published: July 2018

Algal-bacterial interactions include mutualism, commensalism, and predation. However, how multiple environmental conditions that regulate the strength and prevalence of a given interaction remains unclear. Here, we test the hypothesis that the prevailing algal-bacterial interaction shifted in two years (2005 versus 2015), due to increased temperature (T) and Saharan dust depositions in high-mountain lakes of Sierra Nevada (S Spain). Our results support the starting hypothesis that the nature of the prevailing algal-bacterial interaction shifted from a bacterivory control exerted by algae to commensalism, coinciding with a higher air and water T as well as the lower ratio sestonic nitrogen (N): phosphorous (P), related to greater aerosol inputs. Projected global change conditions in Mediterranean region could decline the functional diversity and alter the role of mixotrophy as a carbon (C) by-pass in the microbial food web, reducing the biomass-transfer efficiency up the web by increasing the number of trophic links.
A comprehensive analysis of the Korean fir (Abies koreana) genes expressed under heat stress using transcriptome analysis
Authors: Hwang Jung Eun , Kim Yun Jeong , Shin Myung Hwan , Hyun Hwa Ja , Bohnert Hans J. , Park Hyeong Cheol
Published: July 2018

Korean fir (Abies koreana), a rare species endemic to South Korea, is sensitive to climate change. Here, we used next-generation massively parallel sequencing technology and de novo transcriptome assembly to gain a comprehensive overview of the Korean fir transcriptome under heat stress. Sequencing control and heat-treated samples of Korean fir, we obtained more than 194,872,650 clean reads from each sample. After de novo assembly and quantitative assessment, 42,056 unigenes were generated with an average length of 908 bp. In total, 6,401 differentially expressed genes were detected, of which 2,958 were up-regulated and 3,443 down-regulated, between the heat-treated and control samples. A gene ontology analysis of these unigenes revealed heat-stress-related terms, such as “response to stimulus”. Further, in depth analysis revealed 204 transcription factors and 189 Hsps as differentially expressed. Finally, 12 regulated candidate genes associated with heat stress were examined using quantitative real-time PCR (qRT–PCR). In this study, we present the first comprehensive characterisation of Korean fir subjected to heat stress using transcriptome analysis. It provides an important resource for future studies of Korean fir with the objective of identifying heat stress tolerant lines.
Assessment of fine-scale parameterizations at low latitudes of the North Pacific
Authors: Liang Chang-Rong , Shang Xiao-Dong , Qi Yong-Feng , Chen Gui-Ying , Yu Ling-Hui
Published: July 2018

Fine-scale parameterizations based on shear and stratification are widely used to study the intensity and spatial distribution of turbulent diapycnal mixing in the ocean. Two well-known fine-scale parameterizations, Gregg–Henyey–Polzin (GHP) parameterization and MacKinnon–Gregg (MG) parameterization, are assessed with the full-depth microstructure data obtained in the North Pacific. The GHP parameterization commonly used in the open ocean succeeds in reproducing the dissipation rates over smooth topography but fails to predict the turbulence over rough topography. Failure of GHP parameterization over rough topography is attributed to the deviation of internal wave spectrum from the Garrett–Munk (GM) spectrum. The internal wave field over rough topography is characterized by energetic intermediate-scale and small-scale internal waves that are not described well by the GM model. The MG parameterization that is widely used in coastal environments is found to be successful in reproducing the dissipation rates over both smooth and rough topographies. The efficacy of GHP and MG parameterizations in evaluating the dissipation rates has been assessed. The result indicates that MG parameterization predicts the magnitude and variability of the dissipation rates better than the GHP parameterization.
Author Correction: Removal of artificial sweeteners and their effects on microbial communities in sequencing batch reactors
Authors: Li Shaoli , Geng Jinju , Wu Gang , Gao Xingsheng , Fu Yingying , Ren Hongqiang
Published: July 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis
Authors: Masum Md. Abdul , Ichii Osamu , Elewa Yaser Hosny Ali , Nakamura Teppei , Otani Yuki , Hosotani Marina , Kon Yasuhiro
Published: July 2018

This study evaluated endothelial cells and podocytes, both being primary components of the glomerular filtration barrier, in the progression of membranoproliferative glomerulonephritis (MPGN) using modified scanning electron microscopy (mSEM) analysis. BXSB/MpJ-Yaamodel mice exhibited autoimmune-mediated MPGN characterised by elevated serum autoantibody levels, albuminuria, renal dysfunctional parameters, and decreased glomerular endothelial fenestrations (EF) and podocyte foot process (PFP) effacement with immune cell infiltration. Similar to transmission electron microscopy, mSEM revealed a series of pathological changes in basement membrane and densities of EF and PFP in BXSB/MpJ-Yaacompared with control BXSB/MpJ at different stages. Further, immunopositive area of endothelial marker (CD34), podocyte functional molecules (Nephrin, Podocin, Synaptopodin, and Wilms’ tumour 1 (WT1)), and vascular endothelial growth factor A (VEGF A) significantly decreased in the glomerulus of BXSB/MpJ-Yaacompared with BXSB at final stage. The indices of glomerular endothelial injuries (EF density and immunopositive area of CD34 and VEGF A) and podocyte injuries (PEP density and immunopositive area of podocyte functional molecules) were also significantly correlated with each other and with indices of autoimmune disease and renal dysfunction. Thus, our results elucidated the pathological crosstalk between endothelial cells and podocytes in MPGN progression and the usefulness of mSEM for glomerular pathological analysis.
Attention deficit–hyperactivity disorder is associated with allergic symptoms and low levels of hemoglobin and serotonin
Authors: Wang Liang-Jen , Yu Ya-Hui , Fu Ming-Ling , Yeh Wen-Ting , Hsu Jung-Lung , Yang Yao-Hsu , Chen Wei J. , Chiang Bor-Luen , Pan Wen-Harn
Published: July 2018

This study investigated whether common comorbidities or biochemical factors, such as allergic disease, anemia, inflammation, and neurotransmitters, are singly or additively associated with an increased risk of attention deficit–hyperactivity disorder (ADHD). We recruited 216 children diagnosed with ADHD and 216 age-, sex-, height-, weight-, and class-matched controls from 31 elementary schools in Taipei, Taiwan. The International Study of Asthma and Allergies in Childhood questionnaire was used to measure allergic symptoms. Fasting venous blood was collected and analyzed for complete blood count, white blood cell differential count, immunoglobulin (Ig) E level, and serotonin (5-HT) level. The results showed that symptoms of both rhinitis (OR = 2.08, 95% CI = 1.42–3.05) and eczema (OR = 1.72, 95% CI = 1.02–2.88) were significantly associated with increased risk of ADHD. Children with ADHD showed considerably lower levels of hemoglobin (p = 0.001) and 5-HT (p < 0.001) and higher IgE level (p < 0.001) and eosinophil count (p = 0.001) than did control children. ADHD risk increased with the number of aforementioned biochemical risk factors present (one factor: OR = 1.87, 95% CI = 0.87–4.18; two factors: OR = 2.90, 95% CI = 1.29–6.48; three factors: OR = 4.47, 95% CI = 1.97–10.13; four factors: OR = 6.53, 95% CI = 2.43–17.57). Findings suggest that either ADHD’s etiology is multidimensional or the aforementioned conditions have shared etiology with ADHD.
Comparative studies of Schiff base-copper(ii) and zinc(ii) complexes regarding their DNA binding ability and cytotoxicity against sarcoma cells
Authors: Vieira Adriana Pires , Wegermann Camila Anchau , Da Costa Ferreira Ana Maria
Published: July 2018

Schiff base-copper(ii) and zinc(ii) complexes were prepared and characterized, and their binding ability to DNA and cytotoxicity against healthy and carcinogenic cells were studied.
A novel electrochemical aptamer–antibody sandwich assay for the detection of tau-381 in human serum
Authors: Shui Bingqing , Tao Dan , Cheng Jing , Mei Yong , Jaffrezic-Renault Nicole , Guo Zhenzhong
Published: July 2018

A novel electrochemical biosensor was developed to detect tau-381 in human serum by aptamer–antibody sandwich assay.
Re-designing the α-synuclein tetramer
Authors: Xu Liang , Bhattacharya Shayon , Thompson Damien
Published: July 2018

Missense mutations double the energy barrier to tetramerization, preserving the pool of potentially amyloidogenic monomers.
Correction: Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies
Authors: Shivatare Sachin S. , Huang Lin-Ya , Zeng Yi-Fang , Liao Jung-Yu , You Tsai-Hong , Wang Shi-Yun , Cheng Ting , Chiu Chih-Wei , Chao Ping , Chen Li-Tzu , Tsai Tsung-I , Huang Chiu-Chen , Wu Chung-Yi , Lin Nan-Horng , Wong Chi-Huey
Published: July 2018

Correction for ‘Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies’ by Sachin S. Shivatare et al., Chem. Commun., 2018, 54, 6161–6164.
Kinetic analysis methods applied to single motor protein trajectories
Authors: Nord A. L. , Pols A. F. , Depken M. , Pedaci F.
Published: July 2018

Molecular motors convert chemical or electrical energy into mechanical displacement, either linear or rotary.
Theoretical exploitation of acceptors based on benzobis(thiadiazole) and derivatives for organic NIR-II fluorophores
Authors: Zhou Bin , Hu Zhubin , Jiang Yanrong , Zhong Cheng , Sun Zhenrong , Sun Haitao
Published: July 2018

A series of acceptors based on benzobis(thiadiazole) and derivatives for organic NIR-II fluorophores are designed using an optimally-tuned range-separated density functional approach.
What's in a name? ‘Coinage-metal’ non-covalent bonds and their definition
Authors: Legon Anthony C. , Walker Nicholas R.
Published: July 2018

Isomorphism among angular geometries of halogen- and ‘coinage metal’-bonded complexes of water.
Switchable oil–water phase separation of ionic liquid-based microemulsions by CO2
Authors: Pei Xiaoyan , Xiong Dazhen , Pei Yuanchao , Wang Huiyong , Wang Jianji
Published: July 2018

Stimuli-responsive ionic liquid microemulsions can be reversibly switched from W/O monophase to oil–water phase separation upon alternate bubbling and removal of CO2.
Sweet graphene: exfoliation of graphite and preparation of glucose-graphene cocrystals through mechanochemical treatments
Authors: González Viviana Jehová , Rodríguez Antonio M. , León Verónica , Frontiñán-Rubio Javier , Fierro José Luis G. , Durán-Prado Mario , Muñoz-García Ana B. , Pavone Michele , Vázquez Ester
Published: July 2018

Mechanochemical treatment with carbohydrates has led to the successful exfoliation of graphite, which could be considered as a sustainable methodology to prepare graphene.
The synthesis of atomic Fe embedded in bamboo-CNTs grown on graphene as a superior CO2 electrocatalyst
Authors: Zhang Huinian , Wang Jie , Zhao Zheng , Zhao Huifang , Cheng Miao , Li Anni , Wang Congwei , Wang Junying , Wang Junzhong
Published: July 2018

Synthesized atomic Fe/bamboo-CNTs/graphene exhibits ∼95% faradaic efficiency in the electroreduction of CO2 into CO at 0.55 V overpotential over 12 h.
Elemental imaging by laser-induced breakdown spectroscopy for the geological characterization of minerals
Authors: Fabre Cécile , Devismes Damien , Moncayo Samuel , Pelascini Frédéric , Trichard Florian , Lecomte Andreï , Bousquet Bruno , Cauzid Jean , Motto-Ros Vincent
Published: July 2018

Evaluation of LIBS-based imaging for the detection of minor and trace elements in minerals with microscopic-scale resolution.
Microphysiological flux balance platform unravels the dynamics of drug induced steatosis
Authors: Ehrlich Avner , Tsytkin-Kirschenzweig Sabina , Ioannidis Konstantinos , Ayyash Muneef , Riu Anne , Note Reine , Ouedraogo Gladys , Vanfleteren Jan , Cohen Merav , Nahmias Yaakov
Published: July 2018

Sensor-integrated liver chip unravels risks of drug-induced fatty liver disease associated with prescription drug use.
Sensitive and rapid detection of pathogenic bacteria from urine samples using multiplex recombinase polymerase amplification
Authors: Chen Junge , Xu Youchun , Yan He , Zhu Yunzeng , Wang Lei , Zhang Yan , Lu Ying , Xing Wanli
Published: July 2018

Multiple detection of pathogenic bacteria from urine samples was achieved on a centrifugal microfluidic chip using RPA.
A mixed phenoxo and end-on azide bridged dinuclear copper(ii) Schiff base complex: synthesis, structure, magnetic characterization and DFT study
Authors: Khan Samim , Herrero Santiago , González-Prieto Rodrigo , Drew Michael. G. B. , Banerjee Snehasis , Chattopadhyay Shouvik
Published: July 2018

The magnetic properties of a dinuclear copper(ii) Schiff base complex with dissimilar bridges have been investigated through some theoretical calculations (DFT) using suitable modeled structures.
Great enhancement of energy storage density and power density in BNBT/xBFO multilayer thin film hetero-structures
Authors: Chen Pan , Wu Shuanghao , Li Peng , Zhai Jiwei , Shen Bo
Published: July 2018

Lead-free 0.94(Bi0.5Na0.5)0.94TiO3-0.06BaTiO3/BiFeO3 (abbreviated as BNBT/xBFO) multilayer thin film hetero-structures were deposited on Pt(111)/Ti/SiO2/Si substrates using a sol–gel/spin coating method.
Structurally diverse diterpenoids from Isodon pharicus
Authors: Hu Zheng-Xi , Xu Hou-Chao , Hu Kun , Liu Miao , Li Xiao-Nian , Li Xing-Ren , Du Xue , Zhang Yong-Hui , Puno Pema-Tenzin , Sun Han-Dong
Published: July 2018

Twenty-one structurally diverse diterpenoids (1–21), wherein 1, 2, and 4 represented unprecedented architectures, were isolated from Isodon pharicus.
Effect of cationic disorder on the energy generation and energy storage applications of NixCo3−xS4 thiospinel
Authors: Gervas Charles , Khan Malik Dilshad , Zhang Chunyang , Zhao Chen , Gupta Ram K. , Carleschi Emanuela , Doyle Bryan P. , Revaprasadu Neerish
Published: July 2018

Thiospinels show interesting catalytic and energy storage applications, however, the cationic disorder can have major influence on the energy generation and/or energy storage applications.
Silica based inorganic–organic hybrid materials for the adsorptive removal of chromium
Authors: Nayab Sana , Baig Humaira , Ghaffar Abdul , Tuncel Eylül , Oluz Zehra , Duran Hatice , Yameen Basit
Published: July 2018

We employed and compared polymer functionalized silica gel and mesoporous silica as adsorbents for the removal of Cr(vi) from water.
Novel optical temperature sensor based on emission in Pr3+ doped ferroelectric Ba0.7Sr0.3TiO3
Authors: Wei Tang , Haiyong Ni , Qiuhong Zhang , Jianhong Ding
Published: July 2018

Optical temperature sensing based on the variation of the fluorescence intensity ratio of rare-earth materials has become appealing due to its multiple superiorities over electrical temperature sensing.
Development and use of a construct map framework to support teaching and assessment of noncovalent interactions in a biochemical context
Authors: Loertscher Jennifer , Lewis Jennifer E. , Mercer Allison M. , Minderhout Vicky
Published: July 2018

Most chemistry educators agree that deep understanding of the nature of noncovalent interactions is essential for learning in chemistry. Yet decades of research have shown that students have persistent incorrect ideas about these interactions. We have worked in collaboration with a community of chemistry, biology, and biochemistry educators to develop a construct map to guide development of instructional and assessment resources related to the physical basis of noncovalent interactions in a biochemical context. This map was devised using data about student learning and expert perspectives on noncovalent interactions, resulting in a framework that provides a detailed roadmap for teaching and learning related to this essential concept. Here we describe the development of the construct map and our use of it to reform our biochemistry teaching practice. Because biochemistry relies on application of concepts learned in prerequisite courses, this construct map could be useful for wide range of courses including general chemistry, introductory biology, organic chemistry, and biochemistry.
Specific ion effects for polyelectrolytes in aqueous and non-aqueous media: the importance of the ion solvation behavior
Authors: Narayanan Krishnamoorthy Anand , Holm Christian , Smiatek Jens
Published: July 2018

We study the ion-specific counterion condensation behavior around charged polymers in distinct solvents. Our findings reveal the importance of ion solvation behavior in order to rationalize deviations from electrostatic mean field theories.
The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants
Authors: Mousseau F. , Berret J.-F.
Published: July 2018

Inhaled nanoparticles reaching the respiratory zone in the lungs enter first in contact with the pulmonary surfactant. It is shown here that nanoparticles and lipid vesicles formulated from different surfactant mimetics interact predominantlyviaelectrostatic charge mediated attraction and do not form supported lipid bilayers spontaneously.
Graphitization induced by KOH etching for the fabrication of hierarchical porous graphitic carbon sheets for high performance supercapacitors
Authors: Qi Fulai , Xia Zhangxun , Sun Ruili , Sun Xuejing , Xu Xinlong , Wei Wei , Wang Suli , Sun Gongquan
Published: July 2018

Porous graphitic carbons are promising candidates for energy conversion and storage.
Biomimetic Z-scheme photocatalyst with a tandem solid-state electron flow catalyzing H2 evolution
Authors: Yu Weilai , Zhang Shuai , Chen Junxiang , Xia Pengfei , Richter Matthias H. , Chen Linfeng , Xu Wei , Jin Jingpeng , Chen Shengli , Peng Tianyou
Published: July 2018

A biomimetic Z-scheme photocatalyst exhibits dramatically enhanced photocatalytic activity for H2 production, driven by a tandem solid-state electron flow.
Hierarchical porous Li4Ti5O12–TiO2 composite anode materials with pseudocapacitive effect for high-rate and low-temperature applications
Authors: Huang Chao , Zhao Shi-Xi , Peng Hang , Lin Yuan-Hua , Nan Ce-Wen , Cao Guo-Zhong
Published: July 2018

Dual-phase hierarchical porous Li4Ti5O12–TiO2 (HP LTO–TO) microspheres were synthesized using a topochemical conversion method and used as an anode material in high power lithium ion batteries, particularly for use in low temperature applications.
Bioinspired elastic piezoelectric composites for high-performance mechanical energy harvesting
Authors: Zhang Yong , Jeong Chang Kyu , Yang Tiannan , Sun Huajun , Chen Long-Qing , Zhang Shujun , Chen Wen , Wang Qing
Published: July 2018

A bioinspired architecture of piezoceramics is developed for new composite structures overcoming the major limitations of the current piezoelectric polymer composites.
Coral-like directional porosity lithium ion battery cathodes by ice templating
Authors: Huang Chun , Grant Patrick S.
Published: July 2018

Thick cathodes with aligned pore arrays in the predominant ion transport direction made by ice templating provided high areal and gravimetric capacities.
Metal–organic frameworks derived hollow NiS2 spheres encased in graphene layers for enhanced sodium-ion storage
Authors: Bi Ran , Zeng Cheng , Huang Huawen , Wang Xinping , Zhang Lei
Published: July 2018

Hollow NiS2@G spheres assembled from graphene layer coated NiS2 nanoparticles were prepared via one-step calcination of Ni-MOFs involving simultaneous carbonization and sulfidation for enhanced Na+ storage.
Switchable presentation of cytokines on electroactive polypyrrole surfaces for hematopoietic stem and progenitor cells
Authors: Baumgartner Johanna , Jönsson Jan-Ingvar , Jager Edwin W. H.
Published: July 2018

Redox potential-dependent switching of immobilized interleukin-3 presentation towards hematopoietic progenitor cells using electroactive polypyrrole surfaces affects cell viability.
Shape morphing of anisotropy-encoded tough hydrogels enabled by asymmetrically-induced swelling and site-specific mechanical strengthening
Authors: Zhou Xiaohu , Li Tianzhen , Wang Jiahui , Chen Fan , Zhou Dan , Liu Qi , Zhang Liyun , Shen Jiayan , Zhou Xuechang
Published: July 2018

Dually regulated shape morphing of anisotropy-encoded tough hydrogels to sequentially create complex three-dimensional origami structures.
Strategy design for ratiometric luminescence thermometry: circumventing the limitation of thermally coupled levels
Authors: Cheng Yao , Gao Yan , Lin Hang , Huang Feng , Wang Yuansheng
Published: July 2018

State-of-the-art progress in strategy design based on the Ln3+ luminescence involving dual emission construction for ratiometric luminescence thermometry is reviewed.
Environment-friendly, durable, electro-conductive, and highly transparent heaters based on silver nanowire functionalized keratin nanofiber textiles
Authors: Lee Chil-Hyoung , Yun Yong Ju , Cho Hyunjin , Lee Kyu Seung , Park Mira , Kim Hak Yong , Son Dong Ick
Published: July 2018

We demonstrate the fabrication of highly transparent, conductive, durable, and eco-friendly nanofiber (NF) textiles based on keratin/AgNWs stacking structures for high performance flexible heaters.
APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress
Authors: Wen Hongxiu , Kumar Vinod , Lan Xiqian , Shoshtari Seyedeh Shadafarin Marashi , Eng Judith M. , Zhou Xiaogang , Wang Fang , Wang Haichao , Skorecki Karl , Xing Guolan , Wu Guisheng , Luo Huairong , Malhotra Ashwani , Singhal Pravin C.
Published: July 2018

Two coding sequence variants (G1 and G2) of Apolipoprotein L1 (APOL1) gene have been implicated as a higher risk factor for chronic kidney diseases (CKD) in African Americans when compared with European Americans. Previous studies have suggested that the APOL1 G1 and G2 variant proteins are more toxic to kidney cells than the wild-type APOL1 G0, but the underlying mechanisms are poorly understood. To determine whether endoplasmic reticulum (ER) stress contributes to podocyte toxicity, we generated human podocytes (HPs) that stably overexpressed APOL1 G0, G1, or G2 (Vec/HPs, G0/HPs, G1/HPs, and G2/HPs). Propidium iodide staining showed that HP overexpressing the APOL1 G1 or G2 variant exhibited a higher rate of necrosis when compared with those overexpressing the wild-type G0 counterpart. Consistently, the expression levels of nephrin and podocin proteins were significantly decreased in the G1- or G2-overexpressing cells despite the maintenance of their mRNA expressions levels. In contrast, the expression of the 78-kDa glucose-regulated protein ((GRP78), also known as the binding Ig protein, BiP) and the phosphorylation of the eukaryotic translation initiation factor 1 (eIF1) were significantly elevated in the G1/HPs and G2/HPs, suggesting a possible occurrence of ER stress in these cells. Furthermore, ER stress inhibitors not only restored nephrin protein expression, but also provided protection against necrosis in G1/HPs and G2/HPs, suggesting that APOL1 risk variants cause podocyte injury partly through enhancing ER stress.
Existence, uniqueness and asymptotic analysis of optimal control problems for a model of groundwater pollution
Authors: Augeraud-Véron Emmanuelle , Choquet Catherine , Comte Éloïse
Published: July 2018

An optimal control problem of contaminated underground water is considered. The spatio-temporal objective takes into account the economic trade off between the pollutant use –for instance fertilizer– and the cleaning costs. It is constrained by a hydrogeological model for the spread of the pollution in the aquifer. We consider a broad range of reaction kinetics. The aim of the paper is two-fold. On the one hand, we rigorously derive, by asymptotic analysis, the effective optimal control problem for contaminant species that are slightly concentrated in the aquifer. On the other hand, the mathematical analysis of the optimal control problems is performed and we prove in particular that the latter effective problem is well-posed. Furthermore, a stability property of the optimal control process is provided: any optimal solution of the properly scaled problem tends to the optimal solution of the effective problem as the characteristic pollutant concentration decreases.
Study on Waterproof and Air Permeability of Inorganic Insulated Decorative Panel
Authors: Xiang-lei Hu , Hong-jun Wang , Ying Gao
Published: July 2018

According to the climatic characteristics, the paper investigates relation between waterproof and air permeability of inorganic insulated decorative panel. The paper believes there are two main problems in the waterproof of inorganic insulated decorative panel, one is the gap is a weak link for waterproof as some weather proofing silicone sealants have poor elastic modulus, the other is the failure of construction details causes partial waterproofing failure. The composite panel system is best supplied in a complete set by the system supplier, which is a main comprehensive solution to the waterproofing problem of the composite panel. Through analyzing software simulation and experimental construction, the paper puts forward suggestion that hot summer and cold winter areas should take practical technical measures, including the use of the protective layer with high water vapor flux density or the installation of exhaust plugs in the outer wall base, or setting water vapor escaping channel such as PVC exhaust plug in the glue seam, in the actual project.
Design and implementation of ozone desulfurization and denitration control system based on PLC and kingview
Authors: Lin Mei , Sun Chao , Zhang Kai
Published: July 2018

In view of the BinYang existing characteristics of the equipment, the programmable controller PLC combined with ozone desulfurization denitration, design the real-time monitoring, the operation is simple, operation is stable, easy to transplant the FGD control system. The upper computer uses the configuration kingview6.5 software to conduct real-time monitoring system operation, storage system data, and display report, curve, alarm and other information. In this paper, the hardware design, control system configuration, interface design and system optimization of flue gas desulfurization control system are introduced in detail.
Effect of Heat Input on Porosity in High Nitrogen Steel Composite Welds
Authors: Bo CUI , Hong ZHANG , Fengde LIU
Published: July 2018

High-nitrogen steel plates with a thickness of 8 mm are welded with a laser-arc composite heat source for experiment to study the impact of different heat input parameters on the blowhole defect. The results show that with the increase of laser power, welding current and arc voltage, the porosity of welds decreases; with the increase of welding speed, the porosity of welds increases. Appropriately increasing the heat input helps reduce the porosity of the weld.
Identification of process damping for chatter prediction in milling
Authors: Zheng Charles M. , Liang Chou-Fu , Cai Hai-Yi , Zhang Shui-Shen
Published: July 2018

Traditionally, forecasting stability lobe diagram in milling is limited by complex damping identification procedures, so only structural damping from the impact experiment is used for predicting stability lobe diagram in most milling cases. In this study, by using the mathematical expressions among damping ratio, “critical limiting depth of cut” and “worst spindle speed”, it is shown that the predicted “critical limiting depth of cut” based on the structural damping divided by the measured “critical limiting depth of cut” can be approximately equal to the structural damping divided by the total damping. Based on this relationship, it is easy to estimate the total damping or process damping from the experiment within the selected spindle speeds. In practice, this paper presents an easy method for predicting stability lobe diagram using the total damping. At the same time, experiments have confirmed that using the prediction model of total damping can more accurately predict the stability lobe diagram.
Optimization design of scraper angle based on orthogonal test
Authors: Wang Can , Fang Yuanbin , Huang Song , Zhang Guizhi , Meng Qingyu , Liu Xi
Published: July 2018

The scraper angle of milling machine has a direct effect on the milling efficiency. This research establishes the finite element model of scraper, and designs the cutting front angle and the cutting back angle as factor, impact force and the average force for orthogonal test of evaluation indexes. Through simulation analysis, the force is obtained at the different level. At the same time, the simulation results are verified by experiments. The results show that the simulation results of contact force in the X direction are close to the measured results, and prove the accuracy of the simulation results. The optimized scraper is that the cutting angle is 5.5°, and the cutting back angle is 9°. The impact force is minimum, and the resultant of average force and impact force is minimum. The optimization of scraper angle can effectively reduce the impact force and the average force, which provides guidance for the improvement of scraper.
Research on Background Knowledge Based Software Processing Method of Target Height Measurement for 3D Radar
Authors: Lin Xiaobin , Xiang Liping , Zhang Chengzhi , Xie Meng
Published: July 2018

The three-dimensional (3D) radar can detect 3D information of air targets, including range, azimuth and height. It is considered as an important equipment of the air defense detection system in various countries. The precision of target height measurement is the key challenge in radar detection due to the influences of the complex background environment of air targets. This paper considers the background knowledge during target detection. By using the background knowledge of radar position meteorological parameters and multi-dimensional radar position RAG maps etc., this paper proposes an integrated software processing method to improve the precision of target height measurement for 3D radar and designs a height confidence evaluation model to improve the fusion precision of height information in the superior command unit of the radar.
Real-time Projection Method for Augmented Reality Assisted Assembly
Authors: Hong-jie Guo , Fu-zhou Du
Published: July 2018

Recently, the augmented reality technology has become a useful tool for assembly guidance. The projectors have been always used as virtual image output devices. In most situations, real-time and dynamic images projection is essential due to that the components to be assembled are randomly placed and movable. However, the cameras and the projectors are placed in different relative positions, making it difficult to project real time images when we are using augmented reality for assembly. A novel method based on the system of binocular cameras and projector was proposed here to overcome the limitation. We established a method to get the relations of coordinate transform among camera coordinate system, projector coordinate system and world coordinate system based on real-time internal parameter matrix of the projector that we derived. Obtaining the pose information of the cameras without any designed markers in real world was also realized, which is the key technology for the camera-projector assembly visualization system. An assembly experiment of cable laying was conducted and the results showed that using the proposed method the real-time projection for augmented reality assisted assembly was realized.
FCAW vertical welding of “V” butt plate in AC UHV transmission line construction
Authors: Yang Han , Kerui Chen , Yang Li , Bao Qu
Published: July 2018

In twenty-first Century, China vigorously promoted the research and construction of AC and DC transmission technology in order to ensure the optimal allocation of energy resources in a large scale[1]. In the construction of AC UHV transmission line, the welding quality of tower and stiffening plate as the load bearing tower and the tension of the welded structure plays an important role in the overall quality of the steel structure. In the past, the welding process of semi automatic carbon dioxide solid core welding wire often has the characteristics of weld spatter not easy to clean up and low efficiency of welding. The semi-automatic CO2 flux cored arc welding, has the characteristics of current and voltage to adapt to a wide range, melting speed, has important significance for improving the process, this paper describes the technology in practical engineering applications, and developed the basic strategy of training for grid steel structure welding technicians. This paper also lists both V groove plate butt FCAW welding typical welding project, hope this welding process will continue to spread.
Design and analysis of distributed photo-voltaic power station
Authors: Peilei Feng , Hesong Wu , Mingsheng Zhang , Wenkui Wan
Published: July 2018

After the location of the power station is determined, the construction scale of the solar grid connected photo-voltaic power station is mainly with the terrain conditions and the conditions of land use.The selection of solar cell components and installation methods, access to the power grid and other factors are related.In this paper, according to the existing construction conditions in the sewage plant, the area suitable for the layout of the solar cell array is selected.Accordmg to the structural characteristics of existing structures and the prediction of the power load in the sewage plant, the installed capacity of the plan is 4.9218MWp. A 10kV installed switch-gear station is built, and the 1 10kV outlet is connected to the total distribution room power station. The project is completed at once.Solar energy is converted to DC power through photo-voltaic array composed of PV modules. After three phase inverter (DC-AC) is converted to three-phase alternating current, it is converted to AC power that meets the requirements of public power grid and directly connected to the public power grid through the step-up transformer.The construction and operation of photo-voltaic power stations will not cause pollution to the environment, and can also provide some clean energy, which can reduce the use of fossil fuels such as coal.
Study on the strength loss of Multi-hop HF Radio Propagation
Authors: Liu Lingxiao , Lu Tian , Gong Mingxue , Zhang Wuyu
Published: July 2018

The reflections of high frequency (HF) radio waves between ionosphere and earth’s surface make long-distance information transmission possible. In this paper, the propagation process of radio signals was analyzed and the ionosphere was simplified. Considering the strength loss of signals that occurs in the travelling process and at the reflection points, two pairs of differential equations and integral equations were established to simulate the strength variations of HF radio waves and noises. A different equation of SNR was also developed, which utilized the failure threshold of signal-noise-ratio (SNR) as a criterion to evaluate the effectiveness of signals. Meanwhile, the pace of SNR attenuation was simulated when reflections happens on calm ocean, turbulent ocean, smooth terrain and rugged terrain.
Analysis of Stress Inhomogeneous Coefficient of a Continuous Rigid Frame Bridge during Construction Stage
Authors: Shi Jing-xian , Ran Zhi-hong , Zhao Lu-chang
Published: July 2018

The box section which can meet the requirements of wider deck is widely used in the construction of continuous rigid frame bridge. However, the shearing force lag is very obvious, which causes the inhomogeneous distribution of stress in the cross section, and it may threaten the safety of the bridge structure when it is serious. Taking a continuous rigid frame bridge located in Yunnan, China as an example, this paper establishes the finite element calculation model of the bridge to analyze the stress inhomogeneity in the construction stage. The results show that the shear lag coefficient of the section is constantly changing during the dynamic process of construction, with the increase of the length of the cantilever, the shear lag coefficient gradually converges to 1; prestress is the most important factor that causes the lateral inhomogeneity of the positive stress.
Design of remote smart home control system based on the Internet of Things
Authors: Che Yajin
Published: July 2018

With the continuous innovation of related technology and the rapid development of information industry, the Internet of things, as a new product of information technology, has been applied in many fields, especially in the field of residential home. It is of great significance to promote the quality of people's daily life. In view of this, this paper briefly analyzes the collection and transmission of indoor remote control signal. On the basis of this, the design of remote control software is analyzed and discussed. Finally, the practical application test shows that the remote smart home control system designed by this research can realize the effective transmission of the indoor electrical control of information. It can meet the needs of practical use both in controlling accuracy and the delay.
Development of Optimal Management Strategies for the Interception System Using River Water Quality Modeling
Authors: Ma Chen-Yao , Huang Yi-Chu , Kao Chih-Ming
Published: July 2018

This study adopted the water quality model [Water Quality Analysis Simulation Program (WASP)] to simulate and evaluate the impacts of the opening and closure of an interception system at the tributary of Love River on mainstream water quality. The gates were opened respectively for 4, 12, and 24 hours to assess the impact on biochemical oxygen demand (BOD) and ammonia nitrogen (NH3-N) in the water bodies of Love River. The WASP model was used to evaluate the self-purification capacity of the river. According to the results of the model estimation, it takes 5 days for NH3-N and BOD in the water bodies of Love River to return to normal and for the water to restore its original water quality after the closure of the Baozhu Ditch gate. Results of this study can be used as a reference for Love River watershed management, and the WASP modeling can be applied for decision makers to develop appropriate management strategies of the interception system.
Event-driven Modelling Method for Sub-assembly Intelligent Production Line
Authors: Diao Guangzhou , Rao Jing , Zhao Jun
Published: July 2018

Focusing on the design of sub-assemble intelligent production line, an event-driven design method for production line was proposed. With the method, the manufacturing activity was defined as event, and then the relationships among events are analysed to define the input-output and execution behaviours digitally in each stage. Furthermore, the event-driven execution mechanism for multi-stage process was built to describe the production line in digital. The digital model of production line was conducted to explore the event behaviours, which will support the research about data-driven production line simulation in future work.
Research on Correlation Analysis between Process Parameters of NC Machining and Quality Data Based on Grey Relational Analysis
Authors: Wang Ce , Duan Guijiang , Liu Rui , Han Xiong
Published: July 2018

With the wide use of CNC machine tools, data resources are gradually enriched. How to use the collected data resources for quality control becomes a hot topic for researchers. This paper introduces the use of grey correlation analysis theory to establish the relationship between the process parameters of CNC machine tools and quality data, and then provides a theoretical basis for the quality control using the process parameters of CNC machine tools.
Research on Tool Cutting Performance and Turning Simulation
Authors: Liao WEI
Published: July 2018

In order to study the effect of pulse current treatment on tool cutting performance of cemented carbide, on the basis of cutting experiment, the cutting performance of tool was treated by different current density (J=5 A/mm2, 15 A/mm2 and 35 A/mm2)processing and untreated tool was compared. The results showed that after the treatment of pulse current, when the cunent density J increases from 5 A/mm2 to 35 A/mm2, the hardness of small cylindrical sample and the transverse fracture strength of cuboid sample was improved than that untreated sample; the cutting performance increased 5.6%, 8.2% and 10.8% than that untreated tool, tool life has been improved. After the treatment of pulse current, pulse current provides the driving force for dislocation motion, strong driving force is more likely to make the dislocation multiplication and slip, high density dislocation cell is formed within the material, so that the mechanical properties increase significantly. The simulation study of turning processing based on finite element analysis software Deform 3D. The size distribution of cutting force was simulated, the simulation results and the test results were compared and analyzed, which provided guiding significance for the determination of process parameters
Communication methodology between machine tools using MTConnect protocol
Authors: Xiao Wenlei , Huang Huiyue , Zhao Gang
Published: July 2018

Development of smart manufacturing led to a trend of developing autonomous, accessible and cooperative numerical control equipment, which needs a communication subsystem that follows a universal accepted industrial standard. MTConnect has been widely considered as an efficient and sufficient protocol for data collection since its appearance. In this paper, a networked information exchange methodology between computer numerical control systems based on MTConnect technology is proposed, which includes the theoretical architecture of the information exchange module and the implementation of the module based on a CNC systems developed on the TwinCAT platform. A communication system according to the MTConnect protocol for CNC systems was designed, which is able to collect processing data from controllers and transmits those data between controllers by agent and client embedded in the information exchange module. The agent and client which were defined in the protocol were developed through C# language and MTConnect Managed SDK. The proposed methodology was implemented and tested on actual CNC system.
MATEC Web of Conferences – General and efficient algorithms for handling intricate situations in trimmed surface rendering
Authors: Bo Luo , Zhao Gang , Wang Wei , Du Xiaoxiao
Published: July 2018

Trimmed surfaces have been widely used in complicated product design in mechanical engineering especially in complex free form surface models of CAD/CAM/CAE. Focusing on the deficiencies of the algorithms available in published literatures when handling some intricate situations, this paper proposes a more general and efficient algorithm of trimmed surface rendering (ATSR). The ATSR is a general algorithm that can deal with most intricate situations, which frequently occur in practical engineering that no special attention has been paid to in references at hand, as well as common situations. Furthermore, this paper presents a new algorithm for the nodes of polygon connecting into elements (ANCE). The ANCE can handle most tricky polygons appearing in the process of rendering and achieve successful triangulation for the to-be-rendered surface. Preferable results are obtained in the case studies, which indicate that the algorithms (ATSR and ANCE) are efficient and effective in handling complicated as well as common trimmed surface models in real engineering industry.
An Evaluation Model for The Impact of Climate Change on Regional Instability
Authors: Lie Jia-Yi , Duan Hong-Yu , Chen Dong
Published: July 2018

The complication that climate change brings about has been an important issue in recent decades. In this paper, we attempt to find the inner connection between climate change and regional instability, and finally build a novel evaluation model about it. By innovatively utilizing Analytic Hierarchy Process and Entropy Weight Method combined, our model can produce a reliable climate change impact assessment. Empirical results on states of different stability provide strong evidence that our model possesses high feasibility and accuracy in practical use.