bluuebunny/crossref_metadata_2025 huggingface dataset:
Chitosan-Coated Halloysite Nanotubes As Vehicle for Controlled Drug Delivery to MCF-7 Cancer Cells In Vitro
Authors: Nyankson Emmanuel , Aboagye Shadrack O. , Efavi Johnson Kwame , Agyei-Tuffour Benjamin , Paemka Lily , Asimeng Bernard O. , Balapangu Srinivasan , Arthur Patrick K. , Tiburu Elvis K.
Published: May 2021

The aim of the work is to improve the release properties of curcumin onto human breast cancer cell lines using coated halloysite nanotubes (HNTs) with chitosan as a polycation. A loading efficiency of 70.2% (w/w) was attained for loading 4.9 mg of the drug into 0.204 g bed volume of HNTs using the vacuum suction method. Results acquired from Brunauer-Emmett-Teller (BET), Fourier-transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron spectroscopy (SEM), zeta potential, and thermogravimetric analysis (TGA) indicated the presence of the drug and the biopolymer in and around the nanotubes. The release properties of drug-loaded HNTs (DLHNTs) and chitosan-coated drug-loaded HNTs (DLHNTs-CH) were evaluated. The release percentages of DLHNTs and DLHNTs-CH after 6 h were 50.7 and 37%, respectively. Based on the correlation coefficients obtained by fitting the release nature of curcumin from the two samples, the Korsmeyer-Peppas model was found to be the best-fitted model. In vitro cell viability studies were carried out on the human breast cancer cell line MCF-7, using the MTT and trypan blue exclusion assays. Prior to the Trypan blue assay, the IC50 of curcumin was determined to be ~30 µM. After 24 h of incubation, the recorded cell viability values were 94, 68, 57, and 51% for HNTs, DLHNTs-CH, DLHNTs, and curcumin, respectively. In comparison to the release studies, it could be deducted that sustained lethal doses of curcumin were released from the DLHNTs-CH within the same time. It is concluded from this work that the “burst release” of naked drugs could be slowly administered using chitosan-coated HNTs as potential drug carriers.
Microstructure and Wear Resistance of Laser Cladding of Fe-Based Alloy Coatings in Different Areas of Cladding Layer
Authors: Bai Qiaofeng , Ouyang Changyao , Zhao Chunjiang , Han Binhui , Liu Yingliang
Published: May 2021

In this study, laser cladding technology was used to prepare Fe-based alloy coating on a 27SiMn hydraulic support, and a turning treatment was used to obtain samples of the upper and middle regions of the cladding layer. The influence of microstructure, phase composition, hardness, and wear resistance in different areas of the cladding layer was studied through scanning electron microscopy (SEM), X-ray diffractometry (XRD), friction and wear tests, and microhardness. The results show that the bcc phase content in the upper region of the cladding layer is less than that in the middle region of the cladding layer, and the upper region of the cladding layer contains more metal compounds. The hardness of the middle region of the cladding layer is higher than that of the upper region of the cladding layer. At the same time, the main wear mechanism of the upper region of the cladding layer is adhesive wear and abrasive wear. The wear mechanism of the middle region of the cladding layer is mainly abrasive wear, with better wear resistance than the upper region of the cladding layer.
Accuracy of Proximal and Occlusal Contacts of Single Implant Crowns Fabricated Using Different Digital Scan Methods: An In Vitro Study
Authors: Ren Xi , Son Keunbada , Lee Kyu-Bok
Published: May 2021

The purpose of this in vitro study was to compare the accuracy of the proximal and occlusal contacts of single implant crowns fabricated with four data capture methods. The resin models were mounted on an articulator, digitized using a laboratory scanner, and saved as a standard tessellation language (STL) file to serve as the master reference model (MRM). Two different intraoral scan body (ISB) systems were evaluated: polyetheretherketone (PEEK) short scan body (SSB) and PEEK long scan body (LSB) (n = 12). The digital impressions (SSB and LSB) were acquired using an intraoral scanner with ISB. Two different conventional techniques were also evaluated: PEEK short scan body with coping plastic cap (CPC) and pick-up coping (PUC) (n = 12). The implant impressions (CPC and PUC) were recorded using a conventional impression technique. The crown and abutment were fabricated with a milling machine and then placed on the resin model and scanned using a laboratory scanner. The scanned files were saved as STL files to serve as test datasets. The MRM and test datasets were superimposed, and the mesial, distal, and occlusal distances were calculated using a 3D inspection software and statistically analyzed using the Kruskal–Wallis H test (α = 0.05). The direct data capture group had more accurate contact points on the three surfaces, with mesial contact of 64.7 (12.8) µm followed by distal contact of 65.4 (15) µm and occlusal contact of 147 (35.8) µm in the SSB group, and mesial contact of 84.9 (22.6) µm followed by distal contact of 69.5 (19.2) µm and occlusal contact of 115.9 (27.7) µm in the LSB group (p < 0.001). The direct data capture groups are closer to the ideal proximal and occlusal contacts for single implant crowns than the indirect data capture groups. There was no difference in the accuracy between the two types of scan body (SSB and LSB).
Biomechanical Properties of Bone and Mucosa for Design and Application of Dental Implants
Authors: Gasik Michael , Lambert France , Bacevic Miljana
Published: May 2021

Dental implants’ success comprises their proper stability and adherence to different oral tissues (integration). The implant is exposed to different mechanical stresses from swallowing, mastication and parafunctions for a normal tooth, leading to the simultaneous mechanical movement and deformation of the whole structure. The knowledge of the mechanical properties of the bone and gingival tissues in normal and pathological conditions is very important for the successful conception of dental implants and for clinical practice to access and prevent potential failures and complications originating from incorrect mechanical factors’ combinations. The challenge is that many reported biomechanical properties of these tissues are substantially scattered. This study carries out a critical analysis of known data on mechanical properties of bone and oral soft tissues, suggests more convenient computation methods incorporating invariant parameters and non-linearity with tissues anisotropy, and applies a consistent use of these properties for in silico design and the application of dental implants. Results show the advantages of this approach in analysis and visualization of stress and strain components with potential translation to dental implantology.
Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications
Authors: Colletti Alessandro , Cravotto Giancarlo , Citi Valentina , Martelli Alma , Testai Lara , Cicero Arrigo F. G.
Published: May 2021

Euphausia superba, commonly known as krill, is a small marine crustacean from the Antarctic Ocean that plays an important role in the marine ecosystem, serving as feed for most fish. It is a known source of highly bioavailable omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid). In preclinical studies, krill oil showed metabolic, anti-inflammatory, neuroprotective and chemo preventive effects, while in clinical trials it showed significant metabolic, vascular and ergogenic actions. Solvent extraction is the most conventional method to obtain krill oil. However, different solvents must be used to extract all lipids from krill because of the diversity of the polarities of the lipid compounds in the biomass. This review aims to provide an overview of the chemical composition, bioavailability and bioaccessibility of krill oil, as well as the mechanisms of action, classic and non-conventional extraction techniques, health benefits and current applications of this marine crustacean.
Radiotracers for Bone Marrow Infection Imaging
Authors: Jødal Lars , Afzelius Pia , Alstrup Aage Kristian Olsen , Jensen Svend Borup
Published: May 2021

Introduction: Radiotracers are widely used in medical imaging, using techniques of gamma-camera imaging (scintigraphy and SPECT) or positron emission tomography (PET). In bone marrow infection, there is no single routine test available that can detect infection with sufficiently high diagnostic accuracy. Here, we review radiotracers used for imaging of bone marrow infection, also known as osteomyelitis, with a focus on why these molecules are relevant for the task, based on their physiological uptake mechanisms. The review comprises [67Ga]Ga-citrate, radiolabelled leukocytes, radiolabelled nanocolloids (bone marrow) and radiolabelled phosphonates (bone structure), and [18F]FDG as established radiotracers for bone marrow infection imaging. Tracers that are under development or testing for this purpose include [68Ga]Ga-citrate, [18F]FDG, [18F]FDS and other non-glucose sugar analogues, [15O]water, [11C]methionine, [11C]donepezil, [99mTc]Tc-IL-8, [68Ga]Ga-Siglec-9, phage-display selected peptides, and the antimicrobial peptide [99mTc]Tc-UBI29-41 or [68Ga]Ga-NOTA-UBI29-41. Conclusion: Molecular radiotracers allow studies of physiological processes such as infection. None of the reviewed molecules are ideal for the imaging of infections, whether bone marrow or otherwise, but each can give information about a separate aspect such as physiology or biochemistry. Knowledge of uptake mechanisms, pitfalls, and challenges is useful in both the use and development of medically relevant radioactive tracers.
Lipid Nanoparticles Loaded with Iridoid Glycosides: Development and Optimization Using Experimental Factorial Design
Authors: Dąbrowska Marta , Souto Eliana B. , Nowak Izabela
Published: May 2021

Lipid nanoparticles based on multiple emulsion (W/O/W) systems are suitable for incorporating hydrophilic active substances, including iridoid glycosides. This study involved optimization of composition of lipid nanoparticles, incorporation of active compounds (aucubin and catalpol), evaluation of stability of the resulting nanocarriers, and characterization of their lipid matrix. Based on 32 factorial design, an optimized dispersion of lipid nanoparticles (solid lipid:surfactant—4.5:1.0 wt.%) was developed, predisposed for the incorporation of iridoid glycosides by emulsification-sonication method. The encapsulation efficiency of the active substances was determined at nearly 90% (aucubin) and 77% (catalpol). Regarding the stability study, room temperature was found to be the most suitable for maintaining the expected physicochemical parameter values (particle size < 100 nm; polydispersity index < 0.3; zeta potential > |± 30 mV|). Characterization of the lipid matrix confirmed the nanometer size range of the resulting carriers (below 100 nm), as well as the presence of the lipid in the stable β’ form.
Multi-Device Piezoelectric Direct Discharge for Large Area Plasma Treatment
Authors: Korzec Dariusz , Hoppenthaler Florian , Shestakov Anatoly , Burger Dominik , Shapiro Andrej , Andres Thomas , Lerach Simona , Nettesheim Stefan
Published: May 2021

The piezoelectric cold plasma generators (PCPG) allow for production of the piezoelectric direct discharge (PDD), which is a kind of cold atmospheric pressure plasma (APP). The subjects of this study are different arrays of PCPGs for large-area treatment of planar substrates. Two limiting factors are crucial for design of such arrays: (i) the parasitic coupling between PCPGs resulting in minimum allowed distance between devices, and (ii) the homogeneity of large area treatment, requiring an overlap of the activation zones resulting from each PCPG. The first limitation is investigated by the use of electric measurements. The minimum distance for operation of 4 cm between two PCPGs is determined by measurement of the energy coupling from an active PCPG to a passive one. The capacitive probe is used to evaluate the interference between signals generated by two neighboring PCPGs. The second limitation is examined by activation image recording (AIR). Two application examples illustrate the compromising these two limiting factors: the treatment of large area planar substrates by PCPG array, and the pretreatment of silicon wafers with an array of PCPG driven dielectric barrier discharges (DBD).
Diabetic Retinopathy Prediction by Ensemble Learning Based on Biochemical and Physical Data
Authors: Shen Zun , Wu Qingfeng , Wang Zhi , Chen Guoyi , Lin Bin
Published: May 2021

(1) Background: Diabetic retinopathy, one of the most serious complications of diabetes, is the primary cause of blindness in developed countries. Therefore, the prediction of diabetic retinopathy has a positive impact on its early detection and treatment. The prediction of diabetic retinopathy based on high-dimensional and small-sample-structured datasets (such as biochemical data and physical data) was the problem to be solved in this study. (2) Methods: This study proposed the XGB-Stacking model with the foundation of XGBoost and stacking. First, a wrapped feature selection algorithm, XGBIBS (Improved Backward Search Based on XGBoost), was used to reduce data feature redundancy and improve the effect of a single ensemble learning classifier. Second, in view of the slight limitation of a single classifier, a stacking model fusion method, Sel-Stacking (Select-Stacking), which keeps Label-Proba as the input matrix of meta-classifier and determines the optimal combination of learners by a global search, was used in the XGB-Stacking model. (3) Results: XGBIBS greatly improved the prediction accuracy and the feature reduction rate of a single classifier. Compared to a single classifier, the accuracy of the Sel-Stacking model was improved to varying degrees. Experiments proved that the prediction model of XGB-Stacking based on the XGBIBS algorithm and the Sel-Stacking method made effective predictions on diabetes retinopathy. (4) Conclusion: The XGB-Stacking prediction model of diabetic retinopathy based on biochemical and physical data had outstanding performance. This is highly significant to improve the screening efficiency of diabetes retinopathy and reduce the cost of diagnosis.
Novel Methodological Tools for Behavioral Interventions: The Case of HRV-Biofeedback. Sham Control and Quantitative Physiology-Based Assessment of Training Quality and Fidelity
Authors: Ratajczak Ewa , Hajnowski Marcin , Stawicki Mateusz , Duch Włodzisław
Published: May 2021

Scientific research on heart rate variability (HRV) biofeedback is burdened by certain methodological issues, such as lack of consistent training quality and fidelity assessment or control conditions that would mimic the intervention. In the present study, a novel sham HRV-biofeedback training was proposed as a credible control condition, indistinguishable from the real training. The Yield Efficiency of Training Index (YETI), a quantitative measure based on the spectral distribution of heart rate during training, was suggested for training quality assessment. A training fidelity criterion derived from a two-step classification process based on the average YETI index and its standard deviation (YETISD) was suggested. We divided 57 young, healthy volunteers into two groups, each subjected to 20 sessions of either real or sham HRV-biofeedback. Five standard HRV measures (standard deviation of the NN (SDNN), root mean square of the standard deviation of the NN (RMSSD), total power, low-frequency (LF), and high-frequency (HF) power) collected at baseline, after 10 and 20 sessions were subjected to analysis of variance. Application of a training fidelity criterion improved sample homogeneity, resulting in a substantial gain in effect sizes of the group and training interactions for all considered HRV indices. Application of methodological amendments, including proper control conditions (such as sham training) and quantitative assessment of training quality and fidelity, substantially improves the analysis of training effects. Although presented on the example of HRV-biofeedback, this approach should similarly benefit other behavioral training procedures that interact with any of the many psychophysiological mechanisms in the human body.
Space Debris Tracking with the Poisson Labeled Multi-Bernoulli Filter
Authors: Cament Leonardo , Adams Martin , Barrios Pablo
Published: May 2021

This paper presents a Bayesian filter based solution to the Space Object (SO) tracking problem using simulated optical telescopic observations. The presented solution utilizes the Probabilistic Admissible Region (PAR) approach, which is an orbital admissible region that adheres to the assumption of independence between newborn targets and surviving SOs. These SOs obey physical energy constraints in terms of orbital semi-major axis length and eccentricity within a range of orbits of interest. In this article, Low Earth Orbit (LEO) SOs are considered. The solution also adopts the Partially Uniform Birth (PUB) intensity, which generates uniformly distributed births in the sensor field of view. The measurement update then generates a particle SO distribution. In this work, a Poisson Labeled Multi-Bernoulli (PLMB) multi-target tracking filter is proposed, using the PUB intensity model for the multi-target birth density, and a PAR for the spatial density to determine the initial orbits of SOs. Experiments are demonstrated using simulated SO trajectories created from real Two-Line Element data, with simulated measurements from twelve telescopes located in observatories, which form part of the Falcon telescope network. Optimal Sub-Pattern Assignment (OSPA) and CLEAR MOT metrics demonstrate encouraging multi-SO tracking results even under very low numbers of observations per SO pass.
Quercetin Inhibits Colorectal Cancer Cells Induced-Angiogenesis in Both Colorectal Cancer Cell and Endothelial Cell through Downregulation of VEGF-A/VEGFR2
Authors: Uttarawichien Tamonwan , Kamnerdnond Chantra , Inwisai Tasanee , Suwannalert Prasit , Sibmooh Nathawut , Payuhakrit Witchuda
Published: May 2021

Colorectal cancer (CRC) aggressiveness is caused by cancer angiogenesis which promotes the cancer growth and metastasis associated with poor prognosis and poor survival. The vascular endothelial growth factor-A (VEGF-A) and its receptor (VEGFR-2) form the major signaling pathway in cancer angiogenesis. This study aimed to investigate the anti-angiogenesis activity of quercetin in both colorectal cancer cells and endothelial cells. The tube formation of human vein endothelial cells (HUVECs) was determined by using conditioned media of HT-29 cells treated with quercetin co-cultured with HUVECs. The VEGF-A and NF-κB p65 protein expressions in the quercetin-treated HT-29 cells were determined by fluorescence assay and Western blot analysis. The VEGFR-2 protein expression in HUVECs was determined after they were co-cultured with the quercetin-treated HT-29 cells. Quercetin markedly decreased the HT-29 cell-induced angiogenesis in HUVECs. NF-κB p65 and VEGF-A protein expression were also inhibited by quercetin. Moreover, quercetin significantly inhibited VEGFR-2 expression and translocation in HUVECs after they were co-cultured with high dose quercetin-treated HT-29 cells. Taken together, quercetin had an anti-angiogenesis effect on VEGF-A inhibition related to the NF-κB signaling pathway in the HT-29 cells and reduced VEGFR-2 expression and translocation in HUVECs.
Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review
Authors: Vilibic-Cavlek Tatjana , Savic Vladimir , Ferenc Thomas , Mrzljak Anna , Barbic Ljubo , Bogdanic Maja , Stevanovic Vladimir , Tabain Irena , Ferencak Ivana , Zidovec-Lepej Snjezana
Published: May 2021

Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne zoonotic virus distributed worldwide. Since serologic assays are limited to several laboratories, the disease has been underreported, often making it difficult to determine incidence and seroprevalence rates. Although human clinical cases are rarely recorded, LCMV remains an important cause of meningitis in humans. In addition, a fatal donor-derived LCMV infection in several clusters of solid organ transplant recipients further highlighted a pathogenic potential and clinical significance of this virus. In the transplant populations, abnormalities of the central nervous system were also found, but were overshadowed by the systemic illness resembling the Lassa hemorrhagic fever. LCMV is also an emerging fetal teratogen. Hydrocephalus, periventricular calcifications and chorioretinitis are the predominant characteristics of congenital LCMV infection, occurring in 87.5% of cases. Mortality in congenitally infected children is about 35%, while 70% of them show long-term neurologic sequelae. Clinicians should be aware of the risks posed by LCMV and should consider the virus in the differential diagnosis of aseptic meningitis, especially in patients who reported contact with rodents. Furthermore, LCMV should be considered in infants and children with unexplained hydrocephalus, intracerebral calcifications and chorioretinitis. Despite intensive interdisciplinary research efforts, efficient antiviral therapy for LCMV infection is still not available.
FACTORS AFFECTING THE CONSULTATION SKILLS OF SOCIAL WORKERS WHEN SUPPORTING AUTISTIC CHILDREN’S FAMILIES: EVIDENCE IN VIETNAM
Authors: Hiep Thuong Nguyen , Van Tu Kieu , Van Hieu Nguyen
Published: May 2021

The research has identified the factors affecting the level of response to the job requirement of social workers when conducting counseling for families of children with autism in autism care and education centers. To achieve this goal, in this study we surveyed 89 social workers in Hanoi city. The results of the analysis of the multivariate linear regression model have shown that 6 factors have a significant impact on the level of response to the requirement of counseling skills when assisting autistic children's families, including (i) passion for work, (ii) professional knowledge and practical experience, (iii) proactive activeness, (iv) training opportunities to improve qualifications, (v) employment incentives, (vi) job requirements. The results showed that the passion for the job was most appreciated. On this basis, the study offers several meaningful solutions to improve the job response level of social workers when conducting counseling for autistic children's families.
Authentic-interactive activities to promote oral production on a virtual platform
Authors: Flores-González Norma
Published: May 2021

Implementing learning or communicative strategies are not enough to develop oral production when learning English as a Foreign language; indeed, it is necessary to provide authentic activities that engage students in the act of speaking. The objective of this research is to know if the interactive activities operated in the Moodle platform promote oral production and identify the possible association between their scores from the instructional design and their speaking level from a standardized exam.
For this, a longitudinal quantitative approach was carried out during spring 2020 in the Teaching English Bachelor at BUAP, having a sample of 20 subjects. The results demonstrated that the use of authentic-interactive activities improved the students’ speaking competence significantly. Furthermore, this study pretends to contribute with useful theoretical information for teachers and students who want to select appropriate tasks to improve this competence. It is essential to clarify that this is an innovative study since it promotes the use of activities and strategies mediated by technology asynchronously and synchronously, which are flexible and suitable for students’ needs in times of contingence.
Platform for the information network of the economic reactivation program of the TecNM campus San Martín Texmelucan
Authors: Morales-Zamora Vianney , Paredes-Xochihua Maria Petra , López-Muñoz Jesús , Padilla-León Jonathan
Published: May 2021

Web system that allows small entrepreneurs in the San Martín Texmelucan Region and its surroundings to register information about their businesses, such as their address, business hours, information on the products they sell, data from their social networks, the types of shipments and deliveries. In order to promote the information to the outside public, and among the merchants themselves, to know who their suppliers may be. Searches are carried out according to the lines in which businesses were registered, and are presented to users according to opening hours. The project was born out of the need to offer a web platform in which businesses in the San Martín Texmelucan region can register online their products or services that they offer, thus allowing the economy in this region to be reactivated, to face the COVID-19 pandemic, which affected all sectors and economic sectors
Corona bewegt – auch die Bildungswissenschaft. Bildungswissenschaftliche Reflexionen aus Anlass einer Pandemie
Authors: Breinbauer Ines , Krause Sabine , Proyer Michelle
Published: May 2021

Der vorliegende Band nimmt seinen Ausgangspunkt in der krisenhaften Situation um Covid-19. Er hat den Anspruch, mittels wissenschaftlicher Praktiken der Verunsicherung bzw. dem Bruch mit den bisher als „Normalität“ aufgefassten Verhältnissen etwas entgegen zu setzen. Involviert in bildungswissenschaftliche Forschung und Lehre, die sich angesichts der Pandemie in vielfältiger Weise neu verorten und gestalten, wenden sich die Autor*innen grundlegenden bildungswissenschaftlichen Verhältnisbestimmungen in ihren ideellen, kategorialen, sozialen und materiellen Neuverortungen zu. Dabei kommen auch Themen in den Blick, die in bildungswissenschaftlichen Arbeiten bisher eher randständig waren, sich aber als künftige Forschungsthemen zeigen, beispielsweise die Technisierung des Umgangs miteinander. (DIPF/Orig.)
Molecular and Phylogenetic Characteristics of Cytomegaloviruses Isolated from Children in Nizhny Novgorod
Authors: Vankova ОЕ , Brusnigina NF
Published: May 2021

Introduction: Cytomegalovirus (CMV) infection is a serious problem of modern health care. It belongs to the category of socially significant infections and is characterized by polymorphism of clinical manifestations and high child mortality. Abroad, much attention is paid to virus genotyping, determining the role of various genotypes in the development of certain clinical forms of CMV infection, and developing a vaccine against congenital human cytomegalovirus infection. The objective of our study was to assess the genetic diversity of cytomegaloviruses in children of Nizhny Novgorod. Materials and methods: We analyzed clinical CMV isolates from body fluid samples (blood, urine, and saliva), viral DNA and its fragments in 580 children aged from 15 days to 16 years. Molecular biology (PCR, RT-PCR, and sequencing), bioinformatics and statistical methods were applied in the study. Results: We established that CMV detection rates in children varied from 3.8 % to 18.9 % depending on the form of the disease. We assessed various method approaches to genotyping human cytomegalovirus clinical isolates, were first to determine prevalent gB1, gB2, and gN4a CMV genotypes in children in the Russian Federation, and revealed infected cases caused by two and three genotypes simultaneously. The phylogenetic analysis of UL55 and UL73 gene sequences indicates genetic diversity of Russian CMV isolates from children in the Nizhny Novgorod Region. Conclusions: New data on the prevalence of various CMV genotypes in children living in Nizhny Novgorod may be used in the system of epidemiological surveillance of cytomegalovirus infection while the results of genotyping and phylogenetic analysis of clinical CMV isolates may contribute to domestic vaccine development.
Assessment Standards for 5S Implementation on SMEs of Ship Component
Authors: Khoryanton Ampala , Harmanto Sri , Gunawan Ignatius W.
Published: May 2021

This article describes a new idea in applying the 5S concept (Seiri, Seiton, Seiso, Seiketsu, Shitsuke) to create a quality work environment for small and medium-sized enterprises of ship components. The success rate of implementing the 5S concept must be known based on assessing the effectiveness of the 5S concept application. Assessment of the effectiveness of the application of the 5S concept requires measurement indicators that are with the characteristics work environment of small and medium-sized enterprises of ship components. Determination of standard indicators for the implementation of 5S enabling to assessing the effectiveness of the implementation of 5S repeatedly and consistently. Indicators for the assessment of 5S effectiveness are obtained using the Delphi method. The results showed that the Delphi method obtained 37 indicators that can be used to assess the effectiveness of the implementation of 5S on small and medium-sized enterprises of ship components with an agreement of 75% to 100%. This assessment standard can be used in every phase of the 5S implementation, namely the initial implementation stage up to the system maturity stage. This assessment standard can also be used in similar small and medium-sized enterprises implementing 5S.
Impact of Wuhan Lockdown in Early Stage of COVID-19 Outbreak on Sector Returns in Chinese Stock Market
Authors: Liew Venus Khim-Sen
Published: May 2021

The unprecedented Wuhan lockdown due to the outbreak of the COVID-19 pandemic provides a natural experiment that will elucidate its immediate impact on the stock market. Event study methodology is adopted to identify any short-run abnormal returns in the Shanghai Stock Exchange Composite Index and its ten component sectors. This paper reports empirical evidence on the negative short-run impact of the Wuhan lockdown in the face of the pandemic outbreak on all component sectors of the Shanghai Stock Exchange Composite. The health care and information technology sectors, which helped considerably in the fight against the pandemic, were resilient and outperformed the general market in the Shanghai Stock Exchange despite the lockdown. The eight other sectors performed at par with the general market. This confirmation of the counter-cyclical nature of the health care and information technology sectors during the lockdown, which enabled them to overcome the pandemic outbreak, provides valuable insights with which investors can adjust their portfolios in similar situations in the future in a timely manner.
The Barriers of Bike Sharing System in Ipoh City
Authors: Jamaludin Sharinatol Akmanida , Yaacob Nur Fatma Fadilah , Yazid Muhamad Razuhanafi Mat , Yaakub Nik MohdIznan Tuan , Borhan Muhamad Nazri
Published: May 2021

The Bike-sharing systems are popular in most developed countries worldwide, including France, London, Germany, China, Belgium, Mexico, and Brazil. The system benefits the community because users do not have to purchase their bikes. There are many suppliers providing bicycle rental systems for community use in Malaysia, including Obike and Mobike. However, the implementation of this system was not successful because users prefer to use motorized transport. This study aims to identify the barriers that prevent users from using the bike-sharing system. Ten factors have been identified as the most dominant factors that prevent users from switching motor transport to bike-sharing systems. This study used random sampling research; 178 respondents have given feedback from 200 distributed forms. The data analysis method used is the Average Index. Based on the result, the highest average index recorded at the value of >4.00 is the weather condition (heat and rain) that has dampened the interest for cycling with an average score of 4.71. That is followed by distance from home to town, which is too far for cycling with an average of 4.57 points. Meanwhile, the third-highest value is that it takes too long to reach the destination with bicycles with an average score of 4.43. This result, then, can imply the number and location of bicycle rental should be increased. Besides that, more trees and shrubs should be planted to improve urban greenery so that the city is more shaded and cooler to attract commuters to cycle.
Assessment of Groundwater Quality for Drinking and Domestic Purposes through Local Survey and Water Quality Index in Vietnam
Authors: An Huynh The , Bich Tran Thi Ngoc , Yi-Ching Chen , Hien Tran Thi Thu
Published: May 2021

The quality of groundwater resources is increasingly declining, significantly affecting people’s life and health. The study aims to assess public perception on existing groundwater quality and scheme over conventionally used free groundwater. The contemporaneous analytical procedures applied to determine the concentration of physical parameters: total dissolved solids and total solids and chemical parameters: pH, nitrite (N-NO2-), nitrate (N- NO3-), ammonium (N-NH4+/ NH3), iron (FeII + III) and total hardness were collected for 30 drinking water well samples located in 5 Quarters (An Hoa, An Loi, Ben Don, Phu Hoa, and Phu Nghi) to calculate the water quality index. The results show that up to 96% of people still use groundwater as their main source of drinking, domestic purposes, although groundwater quality is showing a serious decline in quality. The low pH index ranges from 3.0 ÷ 4.5. On average, 3.5 ÷ 4.0 pH of groundwater samples are outside the permissible limit according to VN standards 09: 2015 (5.5 - 8.5), which makes the water acidic, which harmful to human health. Besides, 10% of groundwater samples had high nitrate content, and 6.67% of water samples had ammonium content that did not meet VN standards 09: 2015. The current state of groundwater quality is not good for cooking and drinking. The results will benefit future groundwater exploitation to support more evidence of water quality and deteriorate the water quality soon, ultimately proving to be disastrous for all living beings in the region.
A entropia de Shannon: uma abordagem axiomática
Authors: Magossi José Carlos , Barros Antônio César da Costa
Published: May 2021

A palavra "entropia" surgiu no ano de 1864, nos trabalhos de Termodinâmica de Rudolf Clausius. Em 1948, Claude E. Shannon utiliza esse mesmo nome para designar uma medida de informação em seu modelo matemático de comunicação, fundamentado nos conceitos de emissor, receptor, canal, ruído, redundância, codificação e decodificação. Com a medida de informação H(X)=-C*sum_{i=1}^n[pi*log (pi)], a entropia de Shannon, torna-se possível analisar a capacidade do canal de comunicação e investir em tratamentos de dados, dando origem ao que se chama atualmente de Teoria da Informação. Além dos aspectos operacionais e tecnológicos da teoria de Shannon, que revelam a era digital, as abordagens matemáticas acerca da fórmula H(X) acabam por revelar também uma vertente voltada às caracterizações de medidas de informação. Entende-se que uma exposição didática da dedução matemática da fórmula de entropia de Shannon, com base em um conjunto de axiomas, seja interessante não somente no sentido pedagógico, mas também para o entendimento da teoria de Shannon. Mostra-se, desse modo, que essa fórmula está imersa em um contexto matemático bem definido (um sistema com axiomas e equações funcionais), que permite, com alterações nos axiomas, definir novas medidas de informação.
Temperature dependence of anisotropic magneto-Seebeck effect in NiPt alloys
Authors: Hirai Takamasa , Modak Rajkumar , Miura Asuka , Seki Takeshi , Takanashi Koki , Uchida Ken-ichi
Published: May 2021

This letter reports systematic measurements of the anisotropic magneto-Seebeck effect (AMSE) of ferromagnetic Ni100−x
Pt
x
alloys with different Pt concentration ratios x. By simultaneously measuring an applied temperature difference and generated thermopower at the same positions, the Seebeck coefficient under a magnetic field is quantified with high reliability at the temperatures ranging from 300 to 550 K. The AMSE of the alloys is maximized at around x = 5 at% in the high temperature range and disappears at the temperatures lower than the Curie temperature. The systematic dataset and experimental techniques established here will invigorate spin caloritronics studies.
Pendampingan Masyarakat di Kampung Salak, Kota Sorong: Pelatihan Teknik Pembenihan Ikan Lele Secara Buatan
Authors:   Teknologi Budidaya Perikanan, Politeknik Kelautan dan Perikanan Sorong, Sorong, Ernawati Ernawati , Sayuti Mohammad ,   Teknologi Budidaya Perikanan, Politeknik Kelautan dan Perikanan Sorong, Sorong, Kadarusman Kadarusman ,   Teknologi Budidaya Perikanan, Politeknik Kelautan dan Perikanan Sorong, Sorong, B. Hismayasari Intanurfehmi ,   Teknologi Budidaya Perikanan, Politeknik Kelautan dan Perikanan Sorong, Sorong, Supriatna Iman ,   Teknologi Budidaya Perikanan, Politeknik Kelautan dan Perikanan Sorong, Sorong, Setia Abadi Agung ,   Teknologi Budidaya Perikanan, Politeknik Kelautan dan Perikanan Sorong, Sorong
Published: May 2021

Purpose: This community service aimed to improve skills and provide knowledge about catfish artificial spawning techniques in aquaculture at Salak village. Method: The activity was carried out with an interactive method, preceded by a survey of aquaculture location, material provision, accompanied by questions and answers as a problem solver related to catfish artificial spawning techniques and direct practical assistance on artificial spawning techniques. Result: Artificial spawning techniques of catfish result in a faster ovulation process, namely hatching occurs within 18-24 hours so that the availability of seeds is always fulfilled. Conclusions: Training on artificial spawning techniques of catfish provides knowledge to the farmer community about producing catfish seeds quickly to meet consumer demand.
COMPARATIVE STUDY BETWEEN PATWARDAN TECHNIQUE OF DELIVERY AND TRADITIONAL WAY OF DELIVERING BABIES BY PULL OR PUSH METHOD AT MMCH, MADHUBANI, BIHAR
Authors: Paswan Chhote Lal , Jana Debarshi
Published: May 2021

In this paper we discuss the after math of two different approaches of delivering the babies during caesarean section in advanced labour. The two
techniques are “Patwardans Technique” and “Traditional way of delivering the babies by Pull or Push method”. The post-operative factors that
were monitored include uterine extensions, broad ligament haematoma formation relaparotomy, uterine artery ligation and need for blood
transfusions. It was concluded only after studying 200 patients that Patwardans technique is relatively a better technique.
STAFNE BONE CYST OF MANDIBLE - A RARE PSEUDOCYST
Authors: Kalyani Veerbhadra , Kutty Deepti Krishnan , Sathar Reju , Rao Gautam , Srinivas Rachana
Published: May 2021

Background: Stafne bone cyst (SBC) is a bone depression found on the lingual side of the mandible. It is usually asymptomatic and is usually
diagnosed on the routine radiographs as an incidental nding. So it has an unknown prevalence. The lesion resembles many odontogenic
pathologies and the entity remains a diagnostic challenge. The aim of this case report is to describe the clinical and radiological characteristics of a
case of stafne bone cyst and the importance of cone beam computed tomography in conrming the diagnosis.
Method: Analysis of orthopantomogram (OPG) and cone beam computed tomography (CBCT) was done on the basis of diagnostic criteria
described by Stafne.
Result : According to the clinical and radiographic ndings and based on the dental literature, it was concluded that the observed bony cavity was a
Stafne bone defect, located in the angle of mandible below inferior alveolar canal.
Conclusion: Differential diagnosis of SBC's from other possible pathologies that may require treatment and imaging technique selection
according to case is signicant. The use of CBCT is highlighted because of the ne detail of imaging , low radiation dose and limited area exposure
which is benecial for the diagnosis of SBC.
Metastatic leiomyosarcoma of the excluded stomach: a case report
Authors: Nataliê Almeida Silva  , Lister Arruda Modesto dos Santos  , Vitorino Modesto dos Santos
Published: May 2021

Background: Leiomyosarcoma (LMS) represents about 1% of primary malignancies of the stomach, usually evolves with hepatic implants in 2-thirds of cases, and the outcome is frequently poor. With an insidious course, late diagnosis and misdiagnosis with other gastric neoplasia occur. Immunohistochemical evaluations are mandatory to confirm the diagnostic hypothesis. Surgical resection has been the more effective treatment of gastric LMS; however, recurrences after resections and distant metastases may develop in up to 50% of the patients. Doxorubicin, gemcitabine, and docetaxel are therapeutic options, with variable responses. Case presentation: The 52-year-old male herein described with a diagnosis of LMS in the gastric pouch and liver metastasis underwent a Roux-en-Y bypass to treat morbid obesity more than a decade ago. Persistent abdominal pain was a unique symptom, and he had liver metastasis at diagnosis. The initial hypothesis was a metastatic gastrointestinal stromal tumor (GIST) of the excluded stomach and the patient underwent a schedule with imatinib without significant response. After a complete revision of the anatomopathological findings, the patient underwent a new biopsy of the gastric mass, and the immunohistochemical data were consistent with LMS. Then doxorubicin replaced imatinib, later changed by gemcitabine associated with docetaxel. As last control found lesions in the central nervous system, he is under radiotherapy sessions. Conclusion: The diagnosis of gastric LMS often occurs at late stages because of the insidious clinical course. The rate of liver metastasis at diagnosis is high. Besides, the relatively poor response to the alternative management for non-surgical stages of the disease yields severe outcomes.
SELECTION OF MATERIAL FOR THERMAL INSULATION
Authors: Scherbin Sergey , Glotov Valeriy
Published: May 2021

The main requirements for the materials used as thermal insulation and the condition

for the feasibility of using the selected material are considered.
RESEARCH OF CATHODE PROCESS AT CORROSION STANDARDS, PROTECTED BY POLYMERIC TAPES, IN SOLUTION OF NACL
Authors: Yakovleva Ariadna , Sadlovskiy Sergey , Halbaev Vladimir
Published: May 2021

A corrosion study of ST-3 steel samples in a 3% sodium chloride solution was car ried out. The test steel samples were pre-coated with two different polymer films based on styrene acrylic latexes. The analysis of the process of cathodic polarization shows that on the metal in both.
OPPORTUNITIES FOR USING CLOUD SERVERS IN EDUCATION
Authors: Golovkova Elena , Kulygin Valentin , Pozdeev Evgeniy
Published: May 2021

The article discusses the possibility of implementing cloud technologies in the edu cational process. The principle of operation of a cloud server, its functionality, as well as the ad vantages of using cloud services are described
THE STRUCTURE OF THE NETWORK INTERACTION OF THE COMPONENTS OF A COMPUTER TRAINING COMPLEX
Authors: Krivov Maksim , Nechaeva Elena
Published: May 2021

The architecture of the computer simulator platform based on the multi-agent approach is considered.
ANALYSIS OF THE EXISTING CONTROL SYSTEM OF THE TECHNOLOGICAL PROCESS OF HYDROGEN EXTRACTION FROM HYDROGEN-CONTAINING GASES
Authors: Chistoforova Natal'ya , Ushenin Zahar
Published: May 2021

The parameters that need to be controlled have been identified.to maintain the optimal value of the main qualitative indicator of the process. Based on laboratory data, a control graph

of hydrogen content in the finished product
THE RELATIONSHIP BETWEEN THE AVERAGE DENSITY AND THE FLEXURAL STRENGTH OF NON-AUTOCLAVED FOAM CONCRETE BASED ON MICROSILICA
Authors: Golubeva Anzhela , Baranova Al'bina , Skulin Aleksandr , Kocyr' Alina
Published: May 2021

The results of determining the flexural strength of non-autoclaved foam concrete

based on microsilica of different average densities are presented. A formula for calculating the flexural

strength of non-autoclaved foam concrete in the range of average densities from 400 kg/m3

to 1000 kg/m3 is experimentally derived
TECHNIQUE FOR DETERMINING THE AUTOMOBILE SPEED BEFORE COLLISION ACCORDING TO THE PERMANENT DEFORMATIONS OF CONSTRUCTION ELEMENTS
Authors: Ksenofontova Viktoriya , Kiyashko Larisa
Published: May 2021

The technique developed by the authors allows to determine the speed of a vehicle considering the kinetic energy expenditure both on the deformation of automobile elements and parts and on the vehicle displacement after the traffic accident.
TASKS OF ADAPTATION OF TRANSPORT INFRASTRUCTURE TOWARDS NEW TECHNOLOGIES
Authors: Olencevich Viktoriya , Gozbenko Valeriy
Published: May 2021

The problems of implementing an innovative method of increasing the carrying ca pacity of highly loaded sections of railway lines at the level of using their capacity of 0,8 or more are

considered
STABILITY OF THE METAL FRAME ELEMENTS WHEN WORKING IN CRAMPED CONDITIONS
Authors: Savenkov Andrey , Zaenec Evgeniy , Ketner Andrey
Published: May 2021

The static operation of the building frame elements formed from thin-walled open

profiles located in a monolithic foam concrete array is considered. This arrangement increases the

overall stability and fire resistance of the floor beams.
PROPERTIES OF MEMBRANES BASED ON 1-VINYL-1,2,4-TRIAZOL AND VINYL SULPHONIC ACID SODIUM SALT
Authors: Verhozina Yuliya , Pozhidaev Yuriy , Dr. Vaibhav Kulshrestha , Raskulova Tat'yana
Published: May 2021

The composition and structure of the membrane based on the acid-base method of

elemental analysis, IR and NMR spectroscopy were studied. The ion-exchange capacity, proton con ductivity, activation energy, and thermogravimetric analysis of the resulting membranes were studied
OPTIMIZATION OF THE OIL AND GAS PRODUCTION PROCESS IN THE CONCEPT DIGITAL DEPOSITS
Authors: Arsent'ev Oleg , Ivanov Dmitriy , Saharovskaya Kristina
Published: May 2021

The possibilities of using digital technologies in oil and gas production within the

framework of the "Digital Field" concept are considered, and it is determined that the introduction of

intelligent systems in technological processes increases the volume and quality of products while reducing their cost.
JUSTIFICATION OF THE USE OF THE ELECTRIC DRIVE AT THE COMPRESSOR STATIONS OF THE MAIN GAS PIPELINE
Authors: Kononov Dmitriy
Published: May 2021

The situation with the drive of compressor stations of main gas pipelines is

analyzed. Based on the calculations carried out, a conclusion is made about the efficiency of

using electricity for gas pumping
DETERMINING THE TIME BEFORE SATURATION OF CURRENT TRANSFORM ERS WHICH PROVIDES CORRECT FUNCTIONING FAST RELAY PROTECTION DEVICES
Authors: Tinina Lyudmila , Konovalov Yuriy , Istratov Roman
Published: May 2021

A table-graphical method for calculating the saturation time is proposed, which allows

to optimize the process of selecting current transformers and relay protection devices connected to them

to ensure their correct operation in transient ones, accompanied, among other things, by the occurrence

of an aperiodic current component, to minimize errors, relying on table-graphical visualization.
SIMULATION OF METHANOL PLANT WORK WITH THE CATALYST REPLACEMENT
Authors: Danilov Sergey , Chernigovskaya Marina , Semenov Ivan
Published: May 2021

The modeling of the methanol plant work with the copper-containing catalyst was sim ulated. It will determine the possibility of using a low-temperature catalysts on this plant
INDUSTRIAL SAFETY - 2021
Authors: S'emschikov Sergey
Published: May 2021

The changes in the legislation adopted in 2021 on the industrial safety of hazardous

production facilities that use lifting equipment and equipment operating under excessive pressure are

considered
METAPHOR IN THE LANGUAGE OF COMPUTERS
Authors: Grin Nadezhda
Published: May 2021

The article deals with the role of metaphor in the language of computers.
FEATURES OF PRICE FORMATION IN CONSTRUCTION IN RUSSIA AND FOREIGN COUNTRIES
Authors: Dugar-Zhabon Ruslana , Aronov Nikita
Published: May 2021

The features of pricing in construction in Russia and foreign countries are considered.
SMALL BUSINESS IN THE CONSTRUCTION INDUSTRY OF THE IRKUTSK REGION
Authors: Dugar-Zhabon Ruslana , Medko Ivan
Published: May 2021

The role and some problems of small business in the construction industry of the Irkutsk region are considered