bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective Role of Vitamin C and Silymarin Against Olanzapine-Induced Hepatotoxicity in Albino Rats: A Histopathological and Biochemical Study
Authors: Kaleem Shahid , Bhat Ghulam Mohammad , Wani Lateef Ahmad , Zargar Rehana , Kaleem Zahid
Published: December 2024

Background:

Olanzapine is an atypical antipsychotic drug for treating bipolar disorders and Schizophrenia. Regardless of being used as a common antipsychotic
drug, there are reports of hepatic abnormalities caused by using Olanzapine. Silymarin and Vitamin C have been shown to have hepatoprotective
effects.

Objective:

The purpose of the present was to study the hepatotoxic effects of Olanzapine and the hepatoprotective role of Silymarin and Vitamin C on the
Liver of Albino rats.

Methods:

The study was conducted on 24 albino rats. The animals were randomly divided into four groups of six rats each: Group A consisted of six rats and
served as the control group; Group B consisted of six rats who received orally 4mg/kg of Olanzapine daily; Group C consisted of six rats who
received 4mg/kg of Olanzapine plus 200mg/kg of Silymarin daily and Group D consisted of six rats which received orally 4mg/kg of Olanzapine
plus 15mg/kg of Vitamin C daily. The animals were sacrificed in two sittings at four and eight weeks, and tissues were processed by routine
histopathological technique. The liver enzymes (AST, ALP, ALT) were calculated and analyzed statistically using one-way ANOVA.

Results:

It was found that the liver of rats treated with Olanzapine showed sinusoidal dilatation, sinusoidal congestion, central venous congestion, central
venous dilatation, cellular infiltration, and portal triaditis. The liver enzymes (AST, ALP, ALT) were markedly raised in the drug-treated rats,
showing Olanzapine as a hepatotoxic agent. On the other hand, Silymarin and Vitamin C) both proved to show an excellent hepatoprotective effect.

Conclusion:

Olanzapine administration causes histopathological and biochemical abnormalities in the liver. Vitamin C and Silymarin are both potent
hepatoprotective agents against Olanzapine-induced hepatic toxicity.
TLR4 Targeting: A Promising Therapeutic Approach Across Multiple
Human Diseases
Authors: Kumar Sakshi , Sharma Vikram , Yadav Shikha
Published: December 2024

TLR4 stands at the forefront of innate immune responses, recognizing various pathogen-
associated molecular patterns and endogenous ligands, thus serving as a pivotal mediator in
the immune system's defense against infections and tissue damage. Beyond its canonical role in infection,
emerging evidence highlights TLR4's involvement in numerous non-infectious human diseases,
ranging from metabolic disorders to neurodegenerative conditions and cancer. Targeting TLR4
signaling pathways presents a promising therapeutic approach with broad applicability across
these diverse pathological states. In metabolic disorders such as obesity and diabetes, dysregulated
TLR4 activation contributes to chronic low-grade inflammation and insulin resistance, driving disease
progression. In cardiovascular diseases, TLR4 signaling promotes vascular inflammation and
atherogenesis, implicating its potential as a therapeutic target to mitigate cardiovascular risk. Neurodegenerative
disorders, including Alzheimer's and Parkinson's diseases, exhibit aberrant TLR4
activation linked to neuroinflammation and neuronal damage, suggesting TLR4 modulation as a
strategy to attenuate neurodegeneration.

Additionally, in cancer, TLR4 signaling within the tumor microenvironment promotes tumor progression,
metastasis, and immune evasion, underscoring its relevance as a target for anticancer
therapy. Advances in understanding TLR4 signaling cascades and their contributions to disease
pathogenesis have spurred the development of various pharmacological agents targeting TLR4.
These agents range from small molecule inhibitors to monoclonal antibodies, with some undergoing
preclinical and clinical evaluations. Furthermore, strategies involving TLR4 modulation
through dietary interventions and microbiota manipulation offer additional avenues for therapeutic
exploration. Hence, targeting TLR4 holds significant promise as a therapeutic strategy across a
spectrum of human diseases, offering the potential to modulate inflammation, restore immune
homeostasis, and impede disease progression.
Human Paraoxonase 1: From Bloodstream Enzyme to Disease Fighter &
Therapeutic Intervention
Authors: Khandave Prakash Yadnyakant , Goyal Khushi , Dobariya Prakashkumar , Pande Abhay Hariram
Published: December 2024

Human paraoxonase 1 (hPON1) is a Ca2+-dependent metalloenzyme with multifunctional
properties. Due to its diverse activities (arylesterase, phosphotriesterase, and lactonase), it plays
a significant role in disease conditions. Researchers across the globe have demonstrated different
properties of PON1, like anti-oxidant, anti-inflammatory, anti-atherogenic, anti-diabetic, and OPneutralization.
Due to its pleotropic role in disease conditions like atherosclerosis, diabetes, cardiovascular
diseases, neurodegenerative disorders, and OP-poisoning, it can be considered as a potential
candidate for the development of therapeutic interventions. Attempts are being made in this direction
to identify the exact role of PON1 in these disease conditions. Different approaches like directed
evolution, genetic as well as chemical fusion, liposomal delivery of PON1, etc., are being
developed and evaluated for their therapeutic effects in different pathological conditions. In this review,
we outline the exact role and involvement of different properties of PON1 in the pathophysiology
of different diseases and how it can be utilized and developed as a therapeutic intervention
in PON1-associated disease conditions.
Purification, Characterization, and Antimicrobial Activity Against
Candida parapsilosis and Staphylococcus aureus of a Highly Stable Type-1
Cystatin from Terminalia catappa L. Seeds
Authors: Moura Amanda M.A. , Oliveira José Tadeu A. , Sousa Daniele O.B. , Dias Lucas P. , Araújo Nadine M.S. , de O. Rocha Raquel , Aguiar Tawanny K.B. , Neto João M.M. , Silva Viviane O. , Feitosa Ricardo M. , Chaves Queilane L.S.G. , Ramos Márcio V. , Freitas Cleverson D.T.
Published: December 2024

Introduction:

Clinic infections caused by various microorganisms are a public health
concern. The rise of new strains resistant to traditional antibiotics has exacerbated the problem.
Thus, the search for new antimicrobial molecules remains highly relevant.

Methods:

The current study purified, characterized, and assessed the antimicrobial activity of a papain
inhibitor from Terminalia catappa L. seeds.

Results:

The inhibitor was purified by heating the crude extract at 80°C for 30 min, followed by
ion exchange chromatography on a DEAE cellulose column. The purification index was 9-fold,
yielding 2.3%. SDS-PAGE and size exclusion chromatography revealed that the protease inhibitor
(TcPI) is a 15.9 kDa monomeric protein. The inhibition kinetics showed that TcPI is a competitive
inhibitor specific to papain (Ki = 1.02 x 10-4 M). TcPI remained active even after heating at 100oC
for 120 min and at pH conditions varying from 2.0 to 10.0. Even after 60 min, TcPI was resistant
to papain proteolysis. TcPI exhibited antimicrobial activity against Candida parapsilosis and Staphylococcus
aureus.

Conclusion:

Here, we show that TcPI is a highly stable type-1 cystatin with the potential to combat
infections caused by C. parapsilosis and S. aureus. Additional investigations into TcPI's structural
aspects and mechanism of action, as well as safety assessments, are essential prerequisites
for its potential application as a novel therapeutic intervention.
Preparation and Evaluation of Tetrandrine Nanocrystals to Improve Bioavailability
Authors: Xue Fei , Yang Lan , Ma Shuai , Chang Jin Hua , Liu Pei , Liu Xi Gang , Wang Ru Xing
Published: December 2024

Background:

Tetrandrine (TET) has multiple pharmacological activities, but its water
solubility is poor, which is the main reason for its low bioavailability.

Objectives:

The purpose of this study was to prepare TET nanocrystals (TET-NCs) using a grinding
method to enhance the dissolution rate and ultimately improve the bioavailability of TET.

Methods:

TET-NCs were synthesized via media milling, employing Poloxam 407 (P407) as surface
stabilizer and mannitol as a cryoprotectant during freeze-drying. The crystal structure, particle diameter,
and zeta potential were characterized using differential scanning calorimetry (DSC), Fouriertransform
infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray diffraction
(XRD). The in vitro release behavior and pharmacokinetics of TET-NCs were assessed. The cytotoxicity
of TET and TET-NCS on RAW264.7 cells was determined by the CCK-8 method.

Results:

The particle size of TET-NCs was 360.0±7.03 nm, PDI was 0.26±0.03, and zeta potential
was 6.64±0.22 mV. The cumulative dissolution within 60 minutes was 96.40±2.31%. The pharmacokinetic
study showed that AUC0-72 h and Cmax of TET-NCs were significantly enhanced by 3.07
and 2.57 times, respectively, compared with TET (p<0.01). TET-NCs significantly increased the cell
inhibition on RAW264.7 cells compared to the TET (P<0.01).

Conclusion:

The preparation of TET-NCs enhanced dissolution rate and bioavailability significantly,
and it also improved the inhibition effect of RAW264.7 cells.
Factors Affecting Knowledge Management for the Elderly Health System: Case Studies from Sub-district Municipalities and Administrative Organizations in Thailand
Authors: Limmethee Apichat , Dhirathiti Nopraenue Sajjarax
Published: December 2024

Background

Thailand is in the process of transitioning into an aging society, which will significantly impact the health system for the elderly. Local administrative organizations play a crucial role in providing public health services for the elderly, as they are the closest level of government management to the people. Employing knowledge management in the government sector has enabled the provision of various forms of public services.

Objective

The study aims to explore the factors and conditions related to knowledge management for elderly health within local administrative organizations in Thailand.

Methods

This qualitative research methodology uses a case study design, with the unit of analysis being the Sub-district municipality and Sub-district Administrative Organization. The research tools are interviews and focus groups. The data are analyzed by content and thematic analysis.

Results

The findings indicate that the main factors related to knowledge management for the elderly health system include organizational culture, leadership and vision, supporting networks within the local area, and government agencies. Supporting factors include local culture and community philosophers. Policy suggestions, including local administrative organizations, must act as a coordinator and supporters of the health system for the elderly, emphasizing the creation of a network both inside and outside the area, drawing people of various age groups to join the health network in the local area, and preparing the population to be healthy before they enter the elderly stage.

Conclusion

The study recommends that local administrative organizations prioritize promoting factors within their area to support knowledge management for the elderly health system, which significantly impacts operational success. Furthermore, they should collaborate with other government agencies to address diverse health issues for the elderly.
Recent Advances in the Microbial Oxidation and Ring Rearrangement of Terpenoidal Compounds by Aspergillus niger
Authors: Mohammad Mohammad Yasin , Choudhary M. Iqbal
Published: December 2024

In this review, recent advances in the microbial oxidation and ring rearrangement of various
terpenoidal compounds by Aspergillus niger are reviewed. Studies on hydroxylation, acid and
keto formations, Baeyer-Villiger oxidation, and ring rearrangements are also explored. Moreover,
various terpenoidal compound substrates and their metabolites used for fungal biotransformations are
compiled. This review attempts to cover the latest developments in the scientific literature from 2018
to 2023.
Andrographolides – An Overview
Authors: Karuppusamy S. , Pullaiah T. , Nelson Vinod K.
Published: December 2024

The genus Andrographis is usually bitter and is the source of several
diterpenoids, of which water-soluble labdane diterpenoid is andrographolide. Among
the various diterpene lactones reported from most of the species of Andrographis,
andrographolide is considered one of the major bioactive secondary metabolites. The
genus Andrographis possesses diverse phytochemical constituents with significantly
interesting biological potentials. Diterpenes, flavonoids, xanthoflavones, iridoids, and
other groups of miscellaneous compounds have been characterized from the various
species of Andrographis. Andrographolide has been isolated as a notable major
phytochemical compound among the andrographolides, which is a common diterpene
flavonoid with phytochemical constituents and therapeutic activities.
Botany of Andrographis Wall. ex Nees (Andrographinae: Acanthaceae)
Authors: Simha Yadav P. Bharath , Karuppusamy S.
Published: December 2024

The genus Andrographis Wall. ex Nees is recognized for its potential
medicinal properties, playing a vital role in traditional and indigenous medicinal
systems, particularly in India. It is used for treating various common ailments such as
cold, fever, diarrhea, jaundice, cancer, and tumor. In addition, Andrographis is valued
as a health tonic for fever and cardiovascular health as an antioxidant. Its applications
extend to improving sexual dysfunctions and acting as a contraceptive. The therapeutic
properties of Andrographis are primarily attributed to the major phytochemical
andrographolide, although the composition of phytoconstituents can vary significantly
among different species. These phytochemical variations are significantly influenced
by geographical location, soil types, seasonal changes, and the specific time of harvest.
The diversity in chemical composition highlights the importance of understanding the
specific context and conditions under which Andrographis species are grown and
harvested to optimize their medicinal efficacy. This chapter deals with the botany of
andrographolide-yielding Andrographis species and their taxonomy, identification key,
citation, description, and distribution for their availability and conservation.
Ethnobotany of the Genus Andrographis Wall. ex Nees (Acanthaceae)
Authors: Karuppusamy S.
Published: December 2024

Various species of the Genus Andrographis are used in multiple tribal and
community medicinal systems in India and adjoining countries for more than 20
different local ailments. A. paniculata is predominantly used for treating jaundice, liver
diseases, fever, cardiovascular diseases, cancer, stomach problems, and common cold
and as a blood purifier. This chapter gives an overview of the ethnobotanical uses of
various species of Andrographis by several tribal communities and local inhabitants in
almost all the states of India and other countries.
Silent Suffering: Lymphatic Filariasis in the Heart of India
Authors: S. Binduja , Krishnan Jayalakshmi
Published: December 2024

India bears a significant burden of Lymphatic Filariasis (LF) as one of the
countries with the highest prevalence globally. The prevalence of LF in India is fueled
by a complex interplay of socio-economic factors, inadequate healthcare infrastructure,
and environmental conditions conducive to mosquito breeding. The disease primarily
affects the lymphatic system, leading to severe and disfiguring manifestations such as
lymphedema, elephantiasis, and hydrocele. These debilitating conditions not only
impact the physical health of individuals but also contribute to social stigmatization
and economic hardships. India has undertaken commendable efforts to combat LF
through mass drug administration (MDA) campaigns, which involve the distribution of
antifilarial drugs to entire at-risk populations. However, challenges such as incomplete
coverage, drug compliance, and the persistence of transmission in certain areas hinder
the success of these initiatives.
Produksi dan Kualitas Susu Sapi Perah Peranakan Friesian Holstein (PFH) di KUD Giri Tani Cisarua Bogor
Authors: Selviana Luluk Lifa , Hakim Annisa , Rayani Tera Fit , Resti Yuni , Halimah Binti Nur
Published: December 2024

Penelitian ini bertujuan untuk mengevaluasi produksi susu pada tingkat laktasi yang berbeda dan kandungan nutrien pada berbagai jenis susu. Penelitian diawali dengan menghitung produksi susu pada pagi dan sore hari saat pemerahan dari hari pertama laktasi hingga 13 minggu. Selain itu, dilakukan pengujian kualitas nutrisi susu menggunakan milk analyzer. Variabel yang dianalisa adalah produksi susu dilihat dari perbedaan laktasi dan kualitas susu pada berbagai jenis susu (kolostrum, susu transisi, dan susu penuh) meliputi total solid (TS), berat jenis, lemak (Fat), Bahan Kering Tanpa Lemak (Solid Non Fat), laktosa, dan protein pada susu. Analisis data dilakukan menggunakan uji T pada produksi susu dan Analysis of varience pada kualitas nutrisi susu. Hasil penelitian menunjukkan bahwa tingkat laktasi tidak berpengaruh terhadap produksi susu (P>0,05) antara laktasi kedua dan ketiga. Hasil rataan kualitas susu nutrisi menunjukkan berbeda nyata (P<0,05) adalah berat jenis (kolostrum 1,05%; susu transisi 0,48%; susu penuh 0,39%), TS (kolostrum 22,75%; susu transisi 12,89%; susu penuh 11,05%), BKTL (kolostrum 18,38%; susu transisi 9,21%; susu penuh 7,72%), protein (kolostrum 6,63%; susu transisi 3,06%; susu penuh 2,71%), dan laktosa (kolostrum 9,94%; susu transisi 4,90%; susu penuh 4,08%). Rataan kualitas susu yang menunjukkan tidak berbeda nyata (P>0,05) adalah kadar lemak susu (kolostrum 4,37%; susu transisi 3,67%; susu penuh 3,34%). Kesimpulan penelitian ini adalah produksi susu di peternakan rakyat KUD Giri Tani fluktuaktif dilihat dari laktasi kedua maupun laktasi ketiga dan secara umum kolostrum memiliki nilai kualitas nutrisi yang lebih tinggi dibandingkan dengan kualitas pada susu transisi dan susu penuh.
The relationship of fast food, consumption habits, hemoglobin levels, and sleep quality to menstrual cycle
Authors: Pibriyanti Kartika , Alimah Istiqomah Nurul , Nabawiyah Hafidhotun , Lutfiya Lulu' , Mufidah Indahtul
Published: December 2024

Background: A health problem that often occurs in adolescent girls is disrupting the menstrual cycle. The prevalence of menstrual cycle disorders has increased from 2012 by 45% to 80% in 2018.

Objectives: This study aims to identifying respondent characteristics, determine the relationship between fast food consumption habits, hemoglobin levels and sleep quality on the menstrual cycle. Analyzing which independent variable exerts the most dominant influence on the dependent variable.

Methods: This research design used analytical observational quantitative methods with a case-control approach. The sampling technique used uses purposive sampling. Data collection for menstrual cycles using questionnaires and calendars, data on fast food consumption habits were obtained by interviews using FFQ, and hemoglobin level data were obtained by examination using the Easy Touch GC-Hb tool. In contrast, sleep quality data were obtained using PSQI questionnaires. Data were analyzed by Chi-square then continued with multivariate logistic regression analysis.

Result: The characteristics of respondents in this study based on age mainly were 19 years old, with 49% in the case group and 44% in the control group. Most respondents have an allowance of Rp.500,000-1,000,000, with the percentage in the case group and control group 51%. The menarche age of respondents in this study was mainly 12 years, with a rate of 37%. The characteristics of respondents in the case and control groups mostly have the same distribution of characteristics based on age 19 years, allowance/mounth of Rp.500,000-1,000,000 and age of menstruation 12 years. The study results showed a relationship between fast food consumption habits on the menstrual cycle (p-value= 0.002, OR= 4.359) and there was a relationship between hemoglobin levels on the menstrual cycle (p-value= 0.003, OR= 4.308). There was a relationship between sleep quality on the menstrual cycle (p-value= 0.000, OR= 18.519).

Conclusions: There was a relationship between fast food consumption habits, hemoglobin levels and sleep quality on the menstrual cycle. Hemoglobin levels are at higher risk of menstrual cycles than fast food consumption habits and sleep quality (p-value= 0.042).
Daily consumption of functional egg increases hemoglobin level of children with anemia
Authors: Gunawan Delima Citra Dewi , Agus Ali , Hanif Muhammad Fathin
Published: December 2024

Background: Iron is one of the key elements in optimizing the first 1,000 days of life, including stunting prevention. Eggs are animal proteins that are rich in iron and affordable to all, more economically friendly, compared to other animal protein sources like meat.

Objectives: This study aims to determine the effect of daily consumption of eggs on height and hemoglobin level of anemic children under five in Yogyakarta.

Methods: Double-blind randomized controlled trials were used in the study procedures. The samples included sixteen under-five anemic children, separated into two groups: eight recipients of functional eggs as an intervention group and eight recipients of regular eggs as a placebo group. The intervention was passed during 42 days given continuously1 egg/day in the morning for breakfast.

Results: The results showed that there were 1 stunted child in the treatment group and 2 stunted children in the placebo group The average age of recipients was 38 months in treatment and 33 months in placebo. There was an increase in height and hemoglobin with a difference of 1.3 cm for height and 2.8 gr/dl for hemoglobin in the intervention group after being given treatment for 42 days, whereas in the placebo group there was an increase of 0.5 cm for height and 0. 7 gr/dl for hemoglobin. There was a significant difference in hemoglobin levels after the treatment was given between groups (p=0.010), whereas there was not a difference in height (p=0.328). Meanwhile, within intervention group and the placebo group, there were significant differences in height and hemoglobin before and after being given intervention treatment (p<0.05).

Conclusions: Daily Consumption of Functional eggs for 42 days can significantly increase hemoglobin levels in children with anemia.
Low dietary diversity is associated with stunting among children aged 8-23 months in stunting locus area, Yogyakarta, Indonesia
Authors: Lestari Putri , Irawati Winda , Hositanisita Hastrin , Paratmanitya Yhona , Nurhayati Eka , Yi Lee Yi , Ariftiyana Siska , Rahayu Herwinda Kusuma
Published: December 2024

 

Background: Stunting is impaired growth and development that children experience, caused by poor nutrition during 1000 days of life. Dietary diversity is one of the core indicators for assessing diet quality and adequacy of complementary feeding.

Objectives: This study aimed to analyzed the relationship between dietary diversity and stunting among children aged 8-23 months in Pajangan District, Bantul Regency, Yogyakarta.

Methods: This was a quantitative observational cross-sectional study. Purposive random sampling was used to recruit a total of 167 children aged 8-23 months with their mothers/ caregivers as respondents. Individual dietary diversity was assessed by minimum dietary diversity with the consumption of 5 or more food groups of the total 7 food groups. Logistic regression, chi-square test, and descriptive statistics were used for data analysis.

Results: Results showed that prevalence of stunting was 32.3% and 54.5% of children did not meet the minimum dietary diversity. There was a significant relationship between dietary diversity on complementary feeding and stunting (p=0.005, OR=2.558; 95%CI= 1.422-4.142). Furthermore, other factors related to dietary diversity were child’s age, mother's employment status, father's education, father’s employment, and family income.

Conclusions: There was a relationship between dietary diversity and stunting among children aged 8-23 months in Pajangan District, Bantul Regency, Yogyakarta. Strategy to improve dietary diversity on complementary feeding are needed to prevent child malnutrition.

 

KEYWORDS: complementary feeding; dietary diversity; stunting
The implementation of e-government for village good governance in South Misool, Raja Ampat
Authors: Andriyan Yoga , Munzir M. , Sismar Andi , Wa Ode Likewati  , Athirah Aldila Mawanti , Hidayat Rahmat , Henraman H. , Sakti Dhimas Ari Bhima
Published: December 2024

This community service aims to implement E-Government as a solution to improve village governance in South Misool, Raja Ampat. Villages in the region often face challenges in managing public administration effectively and transparently, especially in the context of remote islands.  The methodology of this service is Preparation, Interview, Socialization, Evaluation, and Reporting. Socialization in this service uses the method of lectures, discussions and sharing sessions. Socialization to improve knowledge and skills about e-government and efficient and effective village governance in South Misool, Raja Ampat. In South Misool, Raja Ampat, the implementation of E-Government reduces bureaucracy and increases the accountability of village governments. In addition, E-Government can help improve the quality of village apparatus human resources through mentoring and technology training, so that they are better prepared to face modern challenges. The results of this service are increasing knowledge of E-Government Implementation for Village Government Governance in South Misool, Raja Ampat (80%), Increasing human resource skills in using E-Government (70%), Increasing knowledge related to e-government-based governance (90%), Increasing knowledge related to public services (90%). It is very necessary to carry out similar activities by carrying out the village government needs to improve technological infrastructure, including adequate internet access and the necessary hardware, to support the implementation of E-Government in the Village Government in South Misool.
Design and socialization of elderly-friendly hydraulic toilets for Elderly Shelter PCA Dau, Malang
Authors: Aisyah Iis Siti , Kurniawati Dini , Hasanah Nur , Ma’arif Moch. Syamsul
Published: December 2024

The spirit of improving the welfare of the elderly is the concern of Amal Usaha Aisyiyah, an autonomous organization under Muhammadiyah by establishing a Shelter for the Elderly in the Dau area, under the management of the Aisyiyah Dau Branch Leadership. One thing that is a serious problem is the need for infrastructure that supports the ease of movement of the elderly. It is common knowledge that the elderly's movements slow down and their motor skills are greatly reduced due to physical factors and age. This is what causes them to fall easily and get injured. And the majority of falls occur in the bathroom, in addition to wet conditions that can cause slipping, also because the toilet is not suitable, or is not friendly to the elderly. This community service is aimed at creating a special toilet design that provides convenience and safety when used. The method applied is by conducting anthropometric observations, interviews with elderly users and administrators and caregivers, conducting design calculations, fabrication followed by product testing and socialization to users. Finally, this community service succeeded in building an elderly-friendly hydraulic toilet with special specifications and has been given to the Shelter for the Elderly. The handover of the product was carried out simultaneously with testing and socialization. This product is expected to increase comfort for the elderly and reduce the occurrence of accidents involving falls in the bathroom.
Legal Rights and Contracts in Esports
Authors: Vural Engin , Karadağ Tuba Fatma
Published: December 2024

Esports has become popular sports branch by the younger generation in recent years, which is played by playing computer games as a team or individually by bringing people from all over the world together via the internet. In this professional sports branch, contracts are made between teams and athletes to keep the promises made in a legal sense. As a result of this professionalism in esports, a branch of esports law has emerged within the scope of sports law to prevent the deprivation of rights in the contracts signed between athletes and teams. The main problem is that there is no special law or a well-established contract model in Turkey regarding the legal dimension of these contracts made between athletes and teams practicing the esports branch and the rights and obligations of athletes and teams. Examples are given from the elements of the contracts signed between the athletes and teams in the esports branch of India and the special provisions of France's contracts and legal provisions related to the esports branch. In this study, the definition of the esports branch, esports law, and the basic elements that should be in esports contracts are mentioned and important suggestions are made by mentioning the elements such as penal procedures, working hours, sponsorship situations, and termination procedures that should be included in the contracts to prevent the athletes from being victimized in the contracts they sign, and it is aimed to contribute to the esports law literature.
Sporcularda Farklı Isınma Çeşitlerinin Fonksiyonel Hareket Analizi Skorlarına ve Bazı Performans Değerlerine Etkisi
Authors: Kaba Sancak Ayşen , Bilgin Ulviye , Çolakoğlu Fatma Filiz , Atıcı Emine
Published: December 2024

Bu araştırmanın amacı, sporcuların statik, dinamik ve kombine germe egzersizlerinden oluşan farklı sınma protokollerinin esneklik, fonksiyonel hareket analizi, dinamik denge, dikey sıçrama, çeviklik ve YMCA adım testi değerleri üzerindeki akut etkilerini incelemek, hangi ısınmanın sporcular için daha uygun olacağını tespit etmektir. Araştırmanın evreni Sakarya ilinde ikamet eden, yaş ortalamaları 15-22 olan, branşlarında ulusal ya da uluslararası müsabakaları katılan, haftada 4-5 gün antrenman yapan, spor yaşı ortalaması en az 5 yıl olan sporculardı. Deneysel tarama yöntemi ile tasarlanan araştırmaya toplam 30 gönüllü sporcu katıldı. Veri toplama aracı olarak ‘‘Sporcu Bilgi Formu’’, ‘‘PARQ Sağlık Anketi’’, ‘‘Tanita vücut analizi cihazı’’, ‘‘Kalp atım ölçer’’, ‘‘Otur uzan sehpası’’, ‘‘FMS ölçüm kiti’’, ‘‘Y Denge ölçüm kiti’’, ‘‘My Jump Pro uygulaması’’ ve ‘T Çeviklik testi’’ kullanıldı. Elde edilen veriler, SPSS 21.0 paket programı ve Shapiro-Wilks testi, Tekrarlayan Ölçümler ANOVA, Friedman testi, Bonferroni ve Wilcoxon işaretli sıra testleri kullanılarak analiz edildi. Sonuç olarak, ısınma protokolü değişikliklerinin esneklik, fonksiyonel hareket analizi, Y denge (sağ anterior), dikey sıçrama, T çeviklik ve YMCA adım testi değerleri arasında anlamlı farklar oluşturduğu bulundu (p
Ritmin Gücü: Türk Kültüründe Müzik ve Spor İlişkisi
Authors: Güleşce Mesut , Kalfa Murat , Sargın Kemal
Published: December 2024

Türk kültüründe müzik, tarih boyunca hem merasimlerde, törenlerde, savaşlarda hem de sağlık ve spor alanında motivasyon, eğlence ve tedavi aracı olarak kullanılmıştır. Spor ise, binlerce yıllık Türk kültürünün önemli bir parçası olmuştur. Bu çalışmanın amacı ise Türk kültüründe müzik ve spor ilişkisini irdeleyerek, günümüzdeki müziğin, spora bağlılığa ve performansa olan etkilerini ortaya koymaktır. Araştırmada nicel araştırma yöntemlerinden ilişkisel tarama modeli ve kolayda örnekleme yöntemi kullanılmıştır. Çalışma grubu spor merkezlerine en az bir yıldır üye olan 189 kadın ve 332 erkek toplam 521 kişiden oluşmaktadır. Verileri toplama araçlarının ilki araştırmacılar tarafından geliştirilen, katılımcıların cinsiyet, müzik dinleme şiddeti, yaş, spor salonuna üyelik süresi, müzik dinleme sıklığı ve dinlenen müzik türü gibi bağımsız değişkenlerle ilgili soruları içeren Kişisel Bilgi Formudur. İkincisi, 3 alt boyuttan ve 18 maddeden oluşan Sportif Uygulamalarda Müziğin Etkisi Ölçeği (SUMEÖ)’dür. Ölçeğin toplam güvenirliği 0.885’dir. Üçüncüsü, üç alt boyut ve 15 maddeden oluşan, toplam güvenirliği 0,91 olan Spora Bağlılık Ölçeği (SBÖ)’dür. Bu araştırmada veri analiz yöntemleri olarak frekans ve yüzde dağılımları, ortalama ve standart sapma gibi betimleyici istatistikler ile korelasyon analizi ve çoklu regresyon analizi kullanılmıştır. Verilerin analizi SPSS 26.0 paket programı kullanılarak gerçekleştirilmiştir. İlk olarak 521 katılımcının demografik ve davranışsal özellikleri incelenmiştir. Hiyerarşik regresyon analizi, demografik değişkenler, müzik dinleme şiddeti, spor yaparken dinlenen müzik türü ve üyelik süresi gibi değişkenlerin bağımlı değişken üzerinde anlamlı etkiler yarattığını ortaya koymuştur. Ayrıca, SUMEÖ ve SBÖ alt boyutları arasında anlamlı pozitif ilişkiler bulunmuş olup, bu durum müziğin sportif performansı hem mental hem de fiziksel olarak pozitif etkilediğini göstermektedir. Sonuç olarak, bu araştırma, müziğin sportif etkinliklerdeki rolünü ve bu etkinliklerin bireylerin spora bağlılıkları üzerindeki etkilerini anlamaya yönelik önemli bulgular sunmaktadır. Bu bulgular, müziğin motivasyonu ve performansı artırmadaki çok yönlü rolünü desteklemekte ve spor merkezleri ile antrenörlere, sporcuların katılımını ve genel refahını artırmak için müziği etkili bir araç olarak kullanma konusunda değerli bilgiler sunmaktadır.
Түүхчлэх үзлийн талаар эргэцүүлэхэд
Authors: Г Ганхуяг
Published: December 2024

Austrian philosopher Karl Poppers works ''The Poverty of Historicism'' and ''The Open society and its Enemies'' are critique of various widely accepted approaches to the methodology of the Philosophy of History. Popper emphasized the conditional character of scientific prediction - its dependence upon universal laws and initial conditions. Popper considers that Falsifiability is a criterion of the scientific character of a theory. Popper was not concerned with meaning, and stressed that metaphysical statements which are not testable - may none the less meaningful and that some had played an important role in the development of science. Popper offered a detailed critique of Plato's, Hegel's, Marks's, Kont's and Miller's works, and he proposed that we should adopt a strategy of piecemeal social planning, in which attempts to solve our collective problems are followed up by the critical scrutiny of their actual outcomes.
SOME NOTES ON THE TRI-PARTITION OF THE SOUL IN THE REPUBLIC
Authors: Khajyet Khajyet
Published: December 2024

Энэхүү өгүүлэл нь Платоны “Төр улс” зохиол дох сэтгэлийн дотоод ангилал ба тэдгээрийг ангилах болсон гол шалтгаан хийгээд нийгмийн анги давхаргуудтай адилтгаж зүйрлэсний шалтгааныг гаргаж тавих гэж оролдсон юм. Улмаар энэ нь Төр улс зохиолын гол утга санаа нь жинхэнэ улс ямар байх ёстой харуулсан гэдэг дүгнэлтэд хүргэж байгаа юм. Тиймээс нийтлэл Төр улс зохиол дээр тулгуурласан текстийн задлан шинжилгээний аргаар тайлал, тайлбарыг хийсэн болно.
ЭКОЛОГИ МЭДЛЭГИЙН АНГИЛАЛЫН АСУУДАЛ
Authors: Г Мэнд-Амар
Published: December 2024

In this article, the modern trends and of category of ecological knowledge are determined as well as I gave my own assessment. Generally, I introduced the relationship between human development and the laws of nature as having classified the eco-centrism and the anthropocentrism.
ТӨВ АЗИЙН ЭРТНИЙ МОНГОЛЧУУДЫН ЯЗГУУР СЭТГЭХҮЙ
Authors: Т Өлзий
Published: December 2024

Төв Азийн эртний монголчуудын язгуур сэтгэхүй
ШИНЭ ЖИЛИЙН АЧЛАЛ ТАХИЛ
Authors: Телеки Кристина
Published: December 2024

The present article entitled ”Thanksgiving Offering at the Lunar New Year” describes a special ritual performed in Mongolian Buddhist monasteries at the Lunar New Year. After listing the different types of thanksgiving offering (danrag, Tib. gtang rag), the performance of Tsederiin danrag (T. tshes gtor gyi dan rag) dedicated to Śrīdevī (Baldan lkham, Tib. Dpal ldan lha mo) at the New Year‟Eve is described. The offered goods are listed with their Mongolian, Tibetan, and Sanskrit names, and Tibetan and Mongolian sutras are examined to find the origin of the ritual. Though one of the aims of the thanksgiving is to thank Śrīdevī‟s support of the year passed, another aim is to encourage her to maintain this support helping the monastery, the monks, and all sentient beings in the New Year as well. It seems that the ritual related to Śrīdevī was first written by the 4th Panchen Lama, Lobsang Chökyi Gyaltsen (T. Blo bzang chos kyi rgyal mtshan, 1570-1662).
ҮЛ УХАМСАРЛАХУЙН ТУХАЙ ПСИХОАНАЛИЗЫН ЗАРИМ ҮЗЭЛ САНАА
Authors: Г Лодой , В.И Владимир
Published: December 2024

Факт, что теория психоанализа оказала соответствущее влияние на развитие западной науки, является неоспорым. Дальнейшее изучение глубинной психологий станет огромным толчком для развития человечества. Изучение бессознательной и подсознательной сфер человеческого сознания приблизит ещё на один шаг к пониманию проблемы менталитета, котороя вызывает всеобщий интерес. Внесение ясности в понимание этих сложых психических феноменов соответсвенно приведёт к эффективному решению социально-экономических пребразований.
БУДДЫН СЭТГЭЛ СУДЛАЛ ДАХЬ МУУ СЭТГЭЛИЙГ Э.БЕРНИЙ ОНОЛ ДАХЬ “ИД”-ТЭЙ ХАРЬЦУУЛАХ НЬ
Authors: Б Туяа , С Нандинцэцэг
Published: December 2024

As result of making comparative research on the suffering on the Buddhist psychology with some ideologies of E. Berne theory, I have made the below mentioned conclusions. Human desire is endless and it is clear fact that every desire is not fulfilled. So human sometimes feel suffering while their endless desire is on the boundary of fulfillment and not-fulfillment. It was clearly investigated by E. Berne in his theory of human nature, who is a famous representative of the neofreudism. The major ideology of this theory is “Id”, which causes various malice, evil and antagonism for human. In the Buddhist theory it is explained that the “Malice”, which causes suffering for human or “Evil” that causes antagonism for human, always lead to “Soul suffering”. As seen from it, the “Id” and “Malice” are similar or coherent in meaning.

In another words, I conclude that both of the theory on human nature by E. Berne and the Buddhist philosophy consider these ideologies (“Id”, “Malice”) same or coherent in meaning. Both of them cause soul suffering for human. With this research I studied the similarity or coherence of some meanings of eastern and western psychology in example of “Id” by E. Berne theory and “Malice” on the Buddhist philosophy. I think that the research on the definite understandings of eastern and western psychology will be helpful and beneficial to scientific study of some researchers and scientists. It also may contribute a little share for wide investigation of this thesis.
ПОСТМОДЕРН ТӨЛӨВ: МЭДЛЭГИЙН ТУХАЙ ИЛТГЭЛ ЗОХИОЛЫН ХЭСГЭЭС
Authors: Б Дагзмаа , Ц Нямсүрэн
Published: December 2024

Жан-Франсуа Лиотар
The Little book of Philosophy номын "Хайр" бүлэг
Authors: Т Дорждагва
Published: December 2024

Андре Комте Спонвилле
“ШАШИН СУДЛАЛЫН ЦОГЦ СУДАЛГАА” НОМЫН “ШАШИН СУДЛАЛ БА ФИЛОСОФИ” БҮЛЭГ (GET SET FOR RELIGIOUS STUDIES. RELIGIOUS STUDIES AND PHILOSOPHY)
Authors: С Дэмбэрэл
Published: December 2024

Доминник Корриврайт, Пегги Морган
THE CONCEPT OF PERSON: SOME BASIC REMARKS
Authors: Sebastian Lalla , Sanjaajab Badraa
Published: December 2024

Person буюу бие хүний тухай дундад эртний үеийн ойлголт нь нийгэм судлалын хүрээнд судалгааны хэрэгсэл болохын хувьд харьцангуй давуу талтай. Ингэж уг ойлголтыг бодит агуулгынх нь талаас бус хэрэглээнд нь авч үзвэл бие хүн нь зөвхөн хэн нэгний нийгэмд гүйцэтгэх ролийг илэрхийлдэг гэхээсээ илүүтэй, зөвхөн тэр хүн (индивид)–ээр илэрхийлэгдэж байгаа бие даасан, өвөрмөц шинжүүдийг илэрхийлж байгаа юм. Энэ үүднээсээ нийгмийн судалгааны практик ажиллагаа нь онолын төвшинд, ойлголтын хүрээнд шалгагдаж, харилцан уялдаатай байх ёстойг харуулж байна.
ТЭВЧЭЭРИЙН ТУХАЙ ФИЛОСОФИ ЕРӨНХИЙ ТОДОРХОЙЛОЛТ ТОМЪЁОЛОХ АСУУДАЛД
Authors: Ц Гомбосүрэн , Г Ичинноров
Published: December 2024

Separating the theoritical and common sense meaning of tolerance, the authors of this article have proposed a formulation that tolerance, theoritically, is human behaviour in which persons or groups of people who have different socio-political status, belief, generally cultural tradition and wealth emphasize on mutually agreeing and understanding each other, choosing nonviolent action solving the controversial issues and obeying legal and moral norms. According to the authors' view, tolerance is specific value and techniques that is not just towards other people, but also toward the world and the nature. That tolerance in the diverse areas of social life have their own distinction has been fully examined in the article.
International Institutions Activity in the Field of Food Security
Authors:   Saint Petersburg State University, Pryanikova Alina A.
Published: December 2024

Globalization processes have had a significant impact on agricultural and food systems around
the world, resulting in a strong correlation between international political and economic events
and food security. The dependence of actors on each other, the transcendental nature of food
problems makes them even more difficult to eliminate. The category of food security itself
reflects not only the food supply of individual households or regions, but also demonstrates
the level of scientific and technological progress, socio-economic development, and the success
of monitoring the natural and climatic situation in the state as a whole. This article examines
the main international organizations involved in solving the problem of food security,
as well as mechanisms aimed at eliminating it.
The aim of the article is to assess the effectiveness of international organizations in the
field of food security.
The scientific novelty of the article consists in the attempt not only to describe the activities
of major international institutions in the field of food security, but also to assess the
effectiveness of these activities against the background of the above-mentioned factors. In the
scientific literature, such studies dating from 2022–2023 have not yet been presented.
The key research method was document analysis.
The empirical basis was statistic data, the speeches and statements of Russian and foreign
politicians and experts in the field of food.
The author identifies the key areas of activity of these organizations in the field of food independently
of each other, as well as in interaction, and offers their assessment of their effectiveness.
The article offers a conclusion about the role of the food problem for the world community
at the present time and about the level of involvement of international organizations in
eliminating this problem. As a result, some new ways of international cooperation in this area
are proposed.
Food Supply and Food Security of the World’s Population in the Conditions of Changing World Order: Management Aspects
Authors:   Saint Petersburg State University of Economics, Holdoenko Artur M.
Published: December 2024

livelihoods of the population. Different population densities, land fertility, and differences in
income levels initiate the use of different approaches to providing the world’s population with
food. The impact of sanctions against Russia on food supply and food security in the world,
in particular considering the “grain deal,” remains poorly understood. The purpose of the work
is to analyze the processes of food supply and achieving food security in the countries of the
world, considering the introduction of sanctions by Western countries against Russia. The
objectives of the study are as follows: to analyze the current situation in food supply, to identify
the main threats to food security in the world as a whole, to propose solutions to reduce
the negative impact of sanctions imposed against some states on third countries. The results
of the study provide substantiation of proposals aimed at resolving issues of ensuring food
security in the world under sanctions pressure on exporters of agricultural products.
Pro-Turkish Islamic Organizations in France as a Tool of the “Soft Power” of the Turkish Republic
Authors:   Russian academy of sciences, Chistyakov Alexey V.
Published: December 2024

The article presents some aspects of the activities of two large socio-spiritual organizations
(«Millî Görüş» and the «Coordinating Committee of Turkish Muslims in France») operating in
the Fifth Republic. These organizations represent the main associations expressing the interests
and values of a significant part of the Turkish diaspora at the national level. Based on the
analysis of statements made by their leaders in the media, communiques posted on social
networks, as well as speeches of French officials, the author has identified a number of main
directions of socio-political activity of these communities, demonstrating both their direct involvement
in political activities in the country and their control by the official Ankara. The article
confirms the fact that the Turkish diasporas are not focused not only on assimilation, but
also on integration into the society of the country of residence. In fact, migrants live in the
country and position themselves as Turks living in France, but not as citizens of the French
Republic of Turkish origin. This approach differs from the Republican understanding of the
word «citizenship». The author also estimated the number of supporters of these organizations.
The conclusions presented in the work show the potential for “practical interaction” of representatives of the Russian diplomatic corps with the two named movements, as well as potential
“directions” of this interaction.
Managing the development of artificial intelligence in Russia through the prism of theory and methodology of strategizing
Authors:   Petrozavodsk State University, Averyanov Aleksandr О.
Published: December 2024

The article considers aspects of strategizing the artificial intelligence (AI) sphere based on the
theory and methodology of strategizing by V. L. Kvint. Using Russia as an example, the article analyzes
key trends and challenges influencing the development of AI, including technological sovereignty,
personnel provision and infrastructure development. The main attention is paid to the relationship
of AI with the processes of reindustrialization and innovative development of the economy.
The article also provides a strategic diagnosis of the state of the Russian AI sphere, including an
analysis of current trends, development prospects and market positioning. Based on the results of
the strategic analysis and the OTSW matrix, five strategic directions for the development of AI in
Russia are proposed, aimed at increasing the economic effect of the implementation of AI, stimulating
scientific research and popularizing AI technologies among the population and business. The
proposed directions can be used to adjust the existing state strategy in the field of AI and ensure
long-term sustainable growth and technological independence of Russia in the context of global
competition.