bluuebunny/crossref_metadata_2025 huggingface dataset:
The developmental deposition of epiblast/germ cell-line derived cells in various organs as a hypothetical explanation of stem cell plasticity?
Authors: Kucia Magda , Machalinski Bogusław , Ratajczak And
Published: December 2023

The embryo develops from germ cell line (fertilized oocyte) and precursors of primordial germ cells (PGC) are the first population of stem cells that are specified in mice at the beginning of gastrulation in proximal primitive ectoderm (epiblast) – region adjacent to the extraembryonic ectoderm. These founder cells subsequently move through the primitive streak and give rise to several extra-embryonic mesodermal lineages and to germ cells. By day 7.25 of embryonic development, a cluster of PGC is visible at the basis of allantois. Subsequently PGC migrate through the embryo proper and colonize genital ridges, where they finally differentiate into sperm and oocytes. We hypothesize that during early development epiblast/germ line-derived cells including PGC become a founder populations of pluripotent stem cells (PSC). These cells are deposited during embryogenesis in various organs and may persist in these locations into adulthood – for example in bone marrow (BM). To support this, we recently identified in BM a population of very small embryonic-like (VSEL) stem cells that express epiblast/germ line-derived cells transcription factor Oct-4 and several other PGC markers. Similarly, cells expressing Oct-4 were also identified in several adult tissues by other investigators. Thus, pluripotent epiblast/PGC may persist beyond embryogenesis in neonatal and adult tissues. Their fate is defined by several mechanisms which regulate cell proliferation and affect status of somatic imprint on selected genes responsible for pluripotency. We hypothesize that these cells play an important role in tissue/organ regeneration and their presence in adult tissues may explain phenomenon of stem cell plasticity. In pathological situations, however they may undergo malignant transformation and give rise to tumors. Correspondence should be addressed to M.Z. Ratajczak, Email: mzrata01@louisville.edu
The role of astrocytes in the physiology and pathology of the central nervous system
Authors: Markiewicz Inga , Lukomska Barbara
Published: December 2023

Astrocytes are the main class of neuroglia, serving a wide range of adaptive functions in the mammalian nervous system. They interact with neurons, providing structural, metabolic and trophic support for them. In pathological circumstances, astrocytes have the potential to induce neuronal dysfunction, but they can also play a neuroprotective role, releasing neuronal growth factors. Here we review recent findings regarding the role of astrocytes in the biology of the brain in physiological conditions, as well as their reaction following the onset of neurodegenerative disorders. Correspondence should be addressed to B. Lukomska, Email: bluk@cmdik.pan.pl
Influence of thyrotropin-releasing hormone (TRH) dialyzed into the hippocampus on memory processes in rabbit
Authors: Orlowska-Majdak Monika , Naziemblo Barbara , Kolodziejski And
Published: December 2023

There are conflicting reports on the influence of thyrotropinreleasing hormone (TRH) on the process of learning. We decided to study this problem using the paradigm of classical eyeblink conditioning as the animal model of learning processes. During the extinction training TRH in its natural form of pGluTRH was applied into the rabbit hippocampus through a chronically implanted microdialysis probe. A Glu1TRH, analog with less biological potency than TRH as the control of specificity for TRH and a 0.9% NaCl solution as the control for both substances were applied by the same way as pGluTRH. We found that pGluTRH extended the process of extinction and enhanced the further acquisition of the reflex. The analog of TRH, Glu1TRH, was ineffective. Finally, it may be stated that TRH acting in the hippocampus prolonged process of forgetting and improved succeeding learning. The effect was specific and long lasting. Correspondence should be addressed to M. Orlowska-Majdak Email: orlowska@zdn.am.lodz.pl
Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice
Authors: Manda Kailash , Anzai Kazunori , Kumari Seema , Bhatia And
Published: December 2023

Oxidative stress has been implicated in cognitive impairment in both experimental animals and humans. This implication has led to the notion that antioxidant defence mechanisms in the brain are not sufficient to prevent oxidative damage, and that dietary intake of a variety of antioxidants might be beneficial for preserving brain function. The present study, therefore, aimed to investigate the protective effect of melatonin against radiation-induced impairment in the learning ability of mice. Twenty days oral administration of melatonin (0.1 mg/kg b.w.), followed by an acute exposure to ¡-radiation (6 Gy), inhibited the radiation-induced decline in learning ability. Biochemical estimation of brain protein carbonyls, malondialdehide (MDA) and reduced glutathione (GSH) in these mice indicated that radiation-induced augmentation of protein oxidation and lipid peroxidation had been significantly ameliorated in melatonin treated, irradiated mice. Radiation-induced deficit of glutathione was also normalized by melatonin administration, as there was no statistical difference from normal at P
Enhancement of Pavlovian conditioned immunosuppression in rats
Authors: Vogel Edgar , Castro María , Solar Paola , Soto And
Published: December 2023

The goal of this study was to define conditions under which conditioned immunosuppression may be observed reliably. In three experiments, rats were exposed to a gustatory conditioned stimulus (CS) paired with cyclophosphamide (US), which induces immunosuppression and malaise. In Experiment 1, a single pairing of the CS with low, medium, or high doses of cyclophosphamide in separate groups produced no reliable conditioned immunosuppression even though conditioned taste aversion was observed in groups trained with high and medium doses of CY. Experiment 2 replicated the lack of effect following a single pairing of the CS with the medium dose of cyclophosphamide but demonstrated that three pairings are sufficient to induce conditioned immunosuppression. Experiment 3 demonstrated that significant immunosuppression is observable following a single CS-US pairing if the CS is presented in compound with a previously nonreinforced CS during training, an effect reminiscent of supernormal conditioning. These findings indicate that conditioned immunosuppression effects can be enhanced in magnitude through the use of certain procedural techniques. Correspondence should be addressed to E. Vogel, Email: evogel@utalca.cl
Emotionally negative stimuli are resistant to repetition priming
Authors: Marchewka Artur , Nowicka Anna
Published: December 2023

The study was aimed at testing whether the repetition priming was influenced by affective valence of visual stimuli. Neutral and emotionally negative words and images were shown in the right or in the left visual field. Each of the stimuli was repeated twice, with 2 to 4 other stimuli presented between repetitions. The subjects' task was detection of a stimulus. Responses were given by index finger of the left or right hand. The task was the same for all stimuli, the new and the repeated ones. Reaction times were measured and analyzed. The effects of repetition priming were significant only for neutral stimuli: repeated items were detected faster than the new ones. For emotionally negative items, generally no priming was observed. Interestingly, new emotionally negative stimuli were detected significantly faster in comparison to neutral stimuli. The results are discussed in relation to attentional processes involved in processing of affective stimuli.
Correspondence should be addressed to A. Marchewka Email: a.marchewka@nencki.gov.pl
Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer's and Parkinson's diseases
Authors: Dorszewska Jolanta , Florczak Jolanta , Rozycka Agata , Kempisty Bartosz , Jaroszewska-Kolecka Joanna , Chojnacka Katarzyna , Trzeciak Wieslaw , Kozubski And
Published: December 2023

Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are accompanied by increased levels of 8-oxo-2'deoxyguanosine (8-oxo2dG) and alterations in levels of homocysteine (Hcy), methionine (Met), and cysteine (Cys). Hcy may undergo remethylation due to involvement of MTHFR, MTR and MTHFD1 proteins. Present studies are aimed at determination of 8-oxo2dG, Hcy, Met, and Cys in AD and PD patients as well as in control groups, using HPLC/EC/UV, as well as estimation, by restriction analysis, frequency of following gene polymorphisms: MTHFR (C677T, A1298C, G1793A), MTHFD1 (G1958A), and MTR (A2756G). In AD there were significant differences of the levels of only Cys (GG, MTHFR, G1793A) and Met/Hcy (AA, MTHFD1, G1958A) whereas in PD there were more significant differences of the levels of thiols: Hcy [MTHFR: CT (C677T) and GG (G1793A); MTR, AG (A2756G)], Met [MTR, AA (A2756G)], Cys [MTR, AG (A2756G)], and Met/Hcy [MTHFR: CC, CT (C677T) and AA (A1298C), and GG (G1793A); MTHFD1 AA (G1958A); MTR AA (A2756G)]. Significant differences in the levels of Cys/Hcy, MTHFD1 GA (G1958) were varied between AD and PD groups. The results indicate that of the enzymes studied only polymorphisms of folate-dependent enzyme MTHFD1 have pointed to significant differences in intensity of turnover of circulating thiols between AD and PD patients.
Correspondence should be addressed to J. Dorszewska, Email: dorszewskaj@yahoo.com
Human cord blood cells can differentiate into retinal nerve cells
Authors: Koike-Kiriyama Naoko , Adachi Yasushi , Minamino Keizo , Iwasaki Masayoshi , Nakano Keiji , Koike Yasushi , Yamada Haruhiko , Mukaide Hiromi , Shigematsu Akio , Mizokami Tomomi , Matsumura Miyo , Ikehara Susumu
Published: December 2023

Retinal degeneration and dystrophy are the major causes of blindness in the developed world. It has been reported that human cord blood cells (HCBCs) can differentiate into neuron-like cells in vitro. We have recently demonstrated that bone marrow cells (BMCs) of both mice and rats can differentiate into retinal nerve cells (RNCs). In the present study, we show the differentiation capacity of HCBCs into RNCs in vivo. We transplanted lineage-negative HCBCs into the subretinal space of severe combined immunodeficiency (SCID) mice. Two weeks after the transplantation, some of the transplanted cells expressed human nestin, human MAP2, human neuron specific enolase (NSE), β-III tubulin and also rhodopsin. These results indicate that HCBCs can differentiate into RNCs and suggest that our new strategy could be used for the regeneration of retinal nerve cells in degenerative or dystrophic diseases.
Evaluasi Efektivitas Mesin Ripple Mill Melalui Pendekatan Overall Equipment Effectiveness (OEE)
Authors: Gian Pramula  , Hamdy Muhammad Ihsan
Published: December 2023

PT Perkebunan Nusantara V (PTPN V), sebuah perusahaan milik negara di sektor perkebunan kelapa sawit, menggunakan beragam mesin dan peralatan yang terhubung secara terintegrasi di Tanah Putih. Proses produksi berlangsung secara berurutan antar mesin, dan kerusakan pada satu stasiun bisa menghambat seluruh produksi. Untuk mengukur efektivitas peralatan, PTPN V Tanah Putih menerapkan metode Overall Equipment Effectiveness (OEE), yang merupakan bagian dari Total Productive Maintenance (TPM). OEE membagi penilaian kinerja peralatan menjadi tiga aspek: Rasio Ketersediaan, Rasio Kinerja, dan Rasio Kualitas. PTPN V Tanah Putih telah mencapai standar internasional dalam nilai OEE. Untuk mempertahankan dan meningkatkan efektivitas mesin, perusahaan melakukan pemeliharaan dan perawatan yang rutin.
Socio-economic burden of TB and its impact on child contacts in The Gambia
Authors: Sillah A. K. , Devoid I. , Ndenkeh J. J. , Moonga G. , Loum I. , Touray A. , Owolabi O. , Sutherland J. , Rachow A. , Ivanova O. , Evans D. , Kampmann B.
Published: December 2023

OBJECTIVE: To determine the social impact of adult TB on child household contacts living in the Greater Banjul Area, The Gambia.METHODS: This was a prospective observational cohort study among adults (≥18 years) starting treatment for drug-susceptible pulmonary
TB between June 2019 and July 2021 who reported having at least one child household contact. We collected data from 51 adults and 180 child contacts at the start of TB treatment (baseline) and again at 6 months of treatment. Participants were asked about expenses for school fees, healthcare,
festivities and food security of child contacts.RESULTS: While school attendance of the child contacts remained largely unaffected, there was a significant drop in school performance at 6 months (P < 0.001). Furthermore, child contacts faced significant food insecurity
in terms of food quantity and variety available, with up to a four-fold increase in some instances at 6 months compared to baseline (P < 0.001)CONCLUSION: Child contacts face a potential decline in school performance and risk of food insecurity. While a plethora of work
is being undertaken to alleviate costs of care for TB patients, further emphasis is needed to ensure educational and social prosperity for child contacts, as adults with TB have socio-economic implications for the wider household.
Descriptors of multidrug-resistant TB deaths in Ethiopia
Authors: Tesema E. , Dememew Z. G. , Datiko D. G. , Gebreyohannes A. , Molla Y. , Tefera A. , Gizatie G. , Bogale T. , Million M. , Suarez P. G. , Aseressa M. M. , Jerene D. , Biru M.
Published: December 2023

Deaths related to multidrug-resistant TB among patients who had received a second-line anti-TB drugs in Ethiopia were analysed. Respectively 38/704 (5.4%) and 44/995 (4.4%) deaths were identified in two cohorts (2015 and 2022). In the 2015 cohort, severe malnutrition was less prevalent,
previous treatment rates were three times higher, hypokalaemia was more frequent, and the use of the Xpert® MTB/RIF assay, respiratory failure and severe anaemia/pancytopenia were less common than in the 2022 cohort. We observed that there were variations in adverse events when different
treatment regimens were used over different time periods. To ensure proper patient care, correct guidance must be consistently implemented.
Participation of private providers in the National TB Programme in South India
Authors: Meundi A. D. , Richardus J. H.
Published: December 2023

SETTING: India has the highest number of new TB cases worldwide. The participation of private providers (PPs) in the National TB Elimination Programme (NTEP) has remained suboptimal.OBJECTIVE: To explore the experiences, barriers and facilitators about their participation
in the NTEP as perceived by PPs working in varied settings.DESIGN: Focus group discussions and in-depth interviews were used to engage PPs to obtain their views on participation in the NTEP. Framework and thematic content analysis was used to analyse qualitative data.RESULTS:
Non-availability of a comprehensive range of diagnostics and lack of flexibility in the NTEP were barriers to participation in NTEP. PPs were predisposed to think that NTEP was for those who could not afford to purchase medications. Attitudes and previous experiences with NTEP made them sceptical
about the NTEP regimen. Although more frequent interactions were sought with NTEP, some bitterness about previous interactions was perceived.CONCLUSION: Challenges identified by PPs for the NTEP include improvement of the quality of TB care, especially at the lower levels of care,
availability of a comprehensive range of diagnostics, being friendly to PPs and patients, more frequent interactions with PPs, and more caring conversations with patients at NTEP centres.
Addressing the needs of people with extensively drug-resistant TB through pre-approval access to drugs and research
Authors: Stillo J. , Frick M. , Galarza J. , Kondratyuk S. , Makone A. , McKenna L. , Vandevelde W. , Winarni P. , Agbassi P.
Published: December 2023

Multiple therapeutic options exist for people with drug-resistant TB (DR-TB), but there is an urgent need to improve access to novel compounds and regimens for people with difficult to treat forms of TB. In additional to formal research studies and clinical trials, other mechanisms
of accessing promising new TB compounds need to be introduced as soon as these drugs have shown efficacy and safety in phase II trials. Pre-approval access programs for newer TB drugs such as bedaquiline, delamanid, and pretomanid all suffered from shortcomings. These can be addressed for
the next generation of new TB drugs through a series of concerted actions by stakeholders at multiple levels. In this viewpoint, we advocate for transparent, accessible pre-approval access as a core element of person-centered care for DR-TB.
The importance of public participation in framing air pollution policy: outcome of a judicial review in New Delhi, India
Authors: Singh R. , Frank A.
Published: December 2023

SETTING: Air pollution, including particulate matter, causes health problems for residents of major cities around the world, including New Delhi, India. Public participation is important in framing policies related to such public health issues.OBJECTIVE: To study how
the public’s comments on air pollution, which had been collected on the orders of the Indian Supreme Court, influenced air pollution policy in New Delhi.DESIGN: We filed a Right to Information Act, 2005 application with the Commission for Air Quality Management (CAQM) to obtain
a copy of the comments. These were compiled and compared with key major areas identified in the policy released by the regulatory authority.RESULTS: There were a wide range of comments from experts, residents and resident associations. In total, 115 comments were compiled and studied,
and several recurring themes were found to have been incorporated into the policy. This included the need to switch to green public transport and cycling, the use of alternative fuels and reduced agricultural crop residue burning.CONCLUSION: Our study revealed that the public and
experts have indeed influenced the CAQM air pollution policy. This is important, as it highlights a democratic, inclusive and stakeholder-based approach. Nonetheless, a future concern lies in how this policy is translated into actionable regulations with effective implementation in the field.
Green synthesis of Ag-Poly (styrene sulfonate) nanoparticles and their application in cotton fabric
Authors: Matsushita Alan Fernando Yoshiaki , Gaudêncio Jéssica da Silva , Garcia Jarem Raul
Published: December 2023

This paper presents a method for the controlled reduction of silver chloride (AgCl) by D-(+)-Maltose in the presence of poly(sodium 4-styrenesulfonate) (PSS). PSS, acting as a polyelectrolyte, plays a crucial role in the process by accommodating silver ions (Ag+) through electrostatic interactions during synthesis and stabilizing the resulting silver nanoparticles (AgNPs). UV-Vis spectra revealed distinct absorption bands characteristic of AgNPs, with the Ag-PSS ratio affecting the size and distribution of nanoparticles. Dynamic light scattering (DLS) and zeta potential measurements confirmed the relationship between silver concentration and nanoparticle uniformity. Layer-by-Layer (LbL) deposition of Ag-PSS nanohybrids on cotton fabric surfaces, offering a unique approach for fabric modification. Energy-Dispersive X-ray Spectroscopy (EDS) analysis demonstrated a consistent increase in silver content with an increase in bilayers. Scanning Electron Microscopy (SEM) revealed enhanced fiber roughness, indicating effective nanohybrid deposition. Elemental mapping showcased uniform elemental distribution across the fiber surface, underscoring the precision of the LbL technique. In conclusion, this study presents an effective method for achieving uniform surface modification of cotton fibers through LbL deposition of Ag-PSS nanohybrids.
Modelagem de dados para realidade virtual e aumentada: desafios e soluções ao lidar com dados espaciais e interativos
Authors: Carr Caroline Nunes , Santos Armando José de Sá , Carr Renato Ferreira , Da Silva Ryan Dias , Vieira André Fernandes , Fernandes Iza Daniela Oliveira
Published: December 2023

Neste artigo sobre as tecnologias de Realidade Virtual (RV) e Realidade Aumentada (RA), destaca-se a importância crucial da modelagem adequada de dados para criar experiências imersivas e interativas. O texto explora os desafios complexos ligados à modelagem de dados espaciais e interativos nesse contexto. São abordados desafios como a representação de objetos tridimensionais de forma precisa, a necessidade de interatividade em tempo real e a integração com diversos sensores e hardwares. Além disso, são discutidas soluções inovadoras, incluindo sistemas de gerenciamento de banco de dados otimizados e o uso de técnicas avançadas de inteligência artificial. Embora progressos significativos tenham sido alcançados pela comunidade acadêmica e pela indústria, o artigo ressalta que ainda há muito espaço para explorar, oferecendo diversas oportunidades para inovações e aprimoramentos.
Impactos socioambientais das estratégias de adaptação e mitigação climática no transporte urbano de passageiros
Authors: Nichi Jaqueline
Published: December 2023

O setor de transportes desempenha um papel relevante nas estratégias de mitigação e adaptação às mudanças climáticas, já que apenas no Brasil é responsável por 65% do consumo de energia. Somente o modal rodoviário responde por cerca de 13% dos 44,5% das emissões de dióxido de carbono equivalente (CO2e) do setor, sendo o principal emissor no segmento de energia. Além de planejamento urbano, o potencial de redução de emissões em sistemas de mobilidade requer uma política integrada que combine uma governança multinível e tecnologias de baixo carbono. Cidades mais compactas, energia limpa e integração entre modais, com priorização do transporte público, são algumas das soluções denominadas inteligentes e sustentáveis. A partir de uma revisão teórica, este artigo visa sintetizar a literatura recente sobre mobilidade inteligente e impactos climáticos e compreender as oportunidades e desafios a partir da abordagem de transição sociotécnica multinível. Essa perspectiva é aplicada ao estudo de caso do sistema de mobilidade da cidade de São Paulo para compreender as barreiras e oportunidades para a transição a um transporte de carbono neutro.
Semeadura de feijão vagem com diferentes discos e velocidades operacionais
Authors: Tavares Jéssica Fernandes , Machado Túlio de Almeida , Costa Anderson Gomide
Published: December 2023

A produção mundial de feijão-vagem atingiu 1.387.667 toneladas em 2019 em uma área de 1.464380 ha. Sua propagação pode ser através da semeadura mecanizada. O objetivo deste trabalho foi avaliar a qualidade de semeadura de feijão-vagem com a utilização de diferentes discos dosadores (28 furos e 72 furos) em uma semeadora de precisão, que operou em diferentes velocidades operacionais (3,6; 5,9 e 8,5 km h-1). O estudo foi conduzido no Instituto Federal Goiano – Campus Morrinhos, localizado no município de Morrinhos/GO, em uma área irrigada via pivô central. O experimento foi instalado em Delineamento em Blocos Casualizados, compostos por um esquema fatorial 3 x 2, (3 velocidades e 2 discos dosadores), perfazendo 6 tratamentos, com 5 repetições, totalizando 30 unidades experimentais. Cada parcela tinha uma área 10 m² (5 x 2 m). Foram determinados parâmetros de qualidade de plantio avaliados pelo teste de Tukey a 5% de probabilidade, e o controle estatístico de processo foi feito por cartas de controle. Para o índice de emergência de plântulas, foi feita uma análise de regressão. Os resultados indicaram que o aumento da velocidade contribuiu para maiores irregularidades na distribuição de sementes, tendo a velocidade de 8,5 km h-1 sido a que proporcionou valores com menos uniformidade, obtendo maior quantidade de espaçamentos falhos. A combinação da velocidade de 3,6 km h-1 com discos de 72 furos demonstrou uma melhor distribuição linear de sementes, com pontos mais próximos do espaçamento ideal no valor de 9,3 cm entre sementes. Esta velocidade também apresentou o menor índice de velocidade de emergência de plantas com o disco de 28 furos.
Decision of The Constitutional Court Regarding the Term of Office of The Head of The Corruption Eradication Commission
Authors: Timbonga Yotham Th.
Published: December 2023

Purpose: The aim of this research is: To find out the term of office of the leadership of the Corruption Eradication Commission in Indonesia and the legal considerations of Constitutional Court Decision No.112/PUU-XX/2022 regarding the term of office of the leadership of the Corruption Eradication Commission.
 
Methode: This research was conducted using normative legal analysis, with the approach method being the statutory regulation approach. An analysis of the results of this research is carried out by criticizing, supporting, or providing comments, then making a conclusion on the research results with your thoughts and the help of a literature review.
 
Result: Constitutional Court Decision Number 112/PUUXX/2022, the term of office of the KPK leadership will be 5 (five) years and they can be re-elected for only one term of office.
 
Conclusions: The Constitutional Court granted the request for an extension of the term of office of the KPK leadership with considerations, namely: Firstly, there is discriminatory and unfair treatment towards the KPK when comparing it with other independent government institutions which have the same constitutional importance. Firstly, there is discriminatory and unfair treatment towards the KPK if it equates it with other independent government institutions which share constitutional importance, namely having a term of office of 5 years. Second, because based on the principles of benefit and efficiency, the 5-year term of office for the leadership of the Corruption Eradication Committee is much more useful and efficient so that it can correspond to one term of office for the president.
Psychological crisis as a necessary factor of development? Human nature according to Kazimierz Dąbrowski
Authors: Kabziński Paweł
Published: December 2023

Kazimierz Dąbrowski believed, that human nature is hierarchical and multilevel in its character. An attribute peculiar for our species is developmental instinct, which differentiates human beings from animals. Dąbrowski indicated, that distinguishing mark of humanity is to be ‘doomed to development’, to reach increasingly higher levels of development, what can be accomplished through processes of disintegration. The key assumption of the Theory of Positive Disintegration (TPD) is that dissolution of internal psychic structures leads to suffering and psychological crisis. But, according to Dąbrowski, it is a generally positive phenomenon, because it is necessary for development of rich and complex psychic structures, and the final goal of processes of disintegration is personality. The aim of this article is to present major terms and assumptions of TPD and also to discuss a Kazimierz Dąbrowski’s perspective for an understanding of some psychological difficulties.
REABILITAÇÃO ESTÉTICA EM DENTE DECÍDUO ANTERIOR COM COROA DE ACETATO: RELATO DE CASO
Authors: De Oliveira David Leite Calou Alves , Freire Maria Luana Sena , Da Silva Juliana Canuto Gonçalves , Clementino Marayza Alves
Published: December 2023

A cárie dentária na infância ainda é uma doença comum entre as crianças, ocasionando problemas funcionais, estéticos e, consequentemente, sociais. Sua etiologia é determinada por bactérias, como Streptococcus mutans e Lactobacillus acidophillus, capazes de produzirem ácidos a partir da fermentação dos carboidratos que associados a uma dieta rica em açúcares, com o passar do tempo, contribuem para a desmineralização dos dentes. Os tratamentos restauradores contemporâneos buscam fazer intervenções cada vez mais conservadoras, preservando o máximo de estrutura dentária e proporcionando um menor tempo de cadeira para os pacientes. Nesse âmbito, o propósito deste trabalho é relatar uma reabilitação estética em dente decíduo anterior com uso de resina composta por técnica direta através do uso de matriz de acetato. Tal método é utilizado quando o remanescente dentário permite a reconstrução com resina composta, servindo como guia para a restauração final, apresentando croma, intensidade e translucidez semelhantes à estrutura perdida. Em síntese, a reabilitação por meio do uso da matriz de acetato com resina composta se mostrou um tratamento clínico satisfatório para lesões cariosas associadas a traumas dentários.
EXPERIÊNCIAS DO USO DAS TECNOLOGIAS SOCIAIS HÍDRICAS COMO INSTRUMENTO DE CONVIVÊNCIA COM O SEMIÁRIDO: O CASO DO DISTRITO AGRÍCOLA DE PENEDO, MARANGUAPE – CE
Authors: Andrade Ana Lúcia Moura , Mendes Lúcia Maria Silveira , Lima Emerson Rodrigues , Mendes Laís Bizerra , De Oliveira Paulo Jerônimo Lucena , Do Nascimento Vilguemberg Silva , Loureiro Luiz Henrique Feitosa , Ferreira Wesley Gomes
Published: December 2023

As tecnologias sociais de convivência com o semiárido brasileiro emergem como uma alternativa viável, em contraposição aos modelos e políticas convencionais de combate a estiagem. Este artigo tem como objetivo discutir experiencias advindas mediante o uso de Tecnologias sociais hídricas – TSHs sobre o Distrito de Penedo. O percurso metodológico traçado para o desenvolvimento da pesquisa se deu mediante o emprego de técnicas estatísticas para determinação da população amostral (famílias produtoras), levantamentos bibliográficos e estudo de campo o qual se deu a aplicação de questionários. Os resultados da pesquisa apontam que as TSHs mais utilizadas no Distrito de Penedo são as barragens artificias, barragem subterrânea, cisternas e cacimbas. Identificou-se que as principais finalidade e aplicação da água armazenadas através das TSHs são para o uso agrícola (irrigação), dessedentação animal e uso domiciliar.
UM OLHAR ACERCA DA IMPORTÂNCIA DOS SABERES DOCENTES NA CONSTITUIÇÃO DA IDENTIDADE DOCENTE
Authors: Melo Ana Valéria Borges de Carvalho , De Oliveira Gildon César , Carneiro Marcelo Teixeira , Melo André Luiz Ferreira de Carvalho
Published: December 2023

O estudo dos saberes docentes é essencial para a melhoria da prática educativa, abrangendo além do conhecimento teórico e acadêmico, incluindo experiências práticas, estratégias pedagógicas eficazes e habilidades interpessoais cruciais para o sucesso na sala de aula. Isso fortalece o ensino, forma professores mais capacitados e conscientes, e permite a adaptação a contextos diversos, promovendo abordagens inovadoras que beneficiam educadores e estudantes. Nesta perspectiva, o propósito deste trabalho consistiu em destacar as contribuições de Maurice Tardif, Selma Garrido Pimenta e Clemont Gauthier para a compreensão dos conhecimentos intrínsecos à prática de ensino. A pesquisa adotou uma abordagem qualitativa, conduzida por meio de uma revisão de literatura, com referências teóricas de Gauthier et al. (2006), Pimenta (2000) e Tardif (2012), entre outros. Ao estabelecer um diálogo com esses três autores fundamentais, o estudo demonstrou que os saberes docentes descritos por eles compartilhavam consistentes pontos de convergência e interligação. De maneira geral, a visão dos autores enfatizou que o professor, enquanto ator social, não apenas adquire conhecimentos, mas também os gera e reproduz por meio de sua prática educativa, levando em consideração suas experiências e aspirações por uma educação de alta qualidade.
ANALYZING THE BIBLIOMETRIC LANDSCAPE OF DIGITAL TRANSFORMATION AND PROJECT MANAGEMENT IN ORGANIZATIONAL CONTEXTS
Authors: Gonçalves Marcelo Luiz do Amaral , Penha Renato , Brandão Afonso César Lelis , Da Costa Filho José Romualdo , Galvão Junior Geovane Soares
Published: December 2023

Digital transformation entails technological shifts, cultural shifts, and alterations in the manner organizations operate and deliver value, necessitating a rethink of organizational strategies and the undertaking of new risks. These changes occur and are needed across various sectors of society. Project management assists in altering the dynamics of organizations, enabling the implementation of new technologies, innovations, and transformations. This article aims to analyze the existing relationship between digital transformation and project management, and to identify the trends of this topic in the literature. The study employs bibliometric analysis to verify the existing relationship and to identify the most explored elements within the topic. The research was confined to the utilization of the Scopus database for data retrieval, wherein 245 articles were found, distributed between the years 2008 and 2020. Through bibliometric pairing, eight factors were identified (Change, Technologies, Strategy, Processes, People, Model, Autonomous Systems, and Artificial Intelligence), confirming the breadth of the topic, its relevance, and the main themes addressed. The findings indicate that the fields of engineering, computer science, and business administration encompass the majority of the studies, enabling scholars to comprehend the contemporary nature of the issues discussed and the trends for future studies.
DEPENDÊNCIA QUÍMICA E SUA RELAÇÃO COM OS TRANSTORNOS MENTAIS EM PACIENTES ATENDIDOS NO CAPS-ad – REVISÃO INTEGRATIVA DE LITERATURA
Authors: Fernandes Elizomar Torres , Nepomuceno Fernanda Karlen Cristo , Soares Ketlen Christiny de Oliveira , Reis Luana Grasielly Soares da Silva , De Lima Orlando Junior Araújo , Figueiredo Silvana Nunes , Coêlho Prisca Dara Lunieres Pêgas , Dos Santos Enock Barroso
Published: December 2023

Objetivo: Descrever a relação entre dependência química e transtornos mentais em pacientes usuários do CAPS-ad e o papel da instituição nos cuidados com esses pacientes. Métodos: Trata-se de uma Revisão Integrativa da Literatura (RIL), onde foram utilizadas as bases de dados LILACS, BDENF. Foram inseridos os estudos publicados nos últimos 10 anos, em Português e Inglês, disponíveis na íntegra em texto completo e que possuía relação com a temática abordada. Resultados: Após a aplicação dos filtros, o total de artigos encontrados foi 140 e selecionados 20. Dentre as individualidades dos participantes em tratamento nos CAPS foram relevantes os comportamentos, transtornos adquiridos, perfil sociodemográficos dos participantes. Considerações Finais: Dentre as substâncias apresentadas como, cocaína, crack, maconha e álcool, são entorpecentes que resultam em doenças mentais, que necessita empenho do usuário, família e equipe multidisciplinar para o tratamento eficaz e eficiente.
UMA ANÁLISE JURÍDICA DE COMO AS TECNOLOGIAS DISRUPTIVAS IMPULSIONARAM O COMÉRCIO ILEGAL DE DROGAS ONLINE
Authors: Araújo Jéssica Caroline de Oliveira , De Oliveira Vinicius Rodrigues Mendes , Teixeira Yuri Serra
Published: December 2023

Este estudo aborda as implicações das tecnologias disruptivas, como a dark web, criptomoedas e meios de comunicação contemporâneos, no surgimento e evolução do comércio ilegal de drogas online. O objetivo é analisar como tais inovações reconfiguraram estratégias criminosas, desafiando a aplicação da lei. Utilizando uma abordagem dedutiva, a pesquisa baseia-se em revisão bibliográfica, documental e teórica, incorporando fontes como livros, periódicos e o documentário “Shiny Flakes: drogas online”. Os resultados destacam o impacto significativo dessas tecnologias na transformação do comércio de drogas, exemplificado pelos casos emblemáticos do Silk Road e Shiny Flakes. A resposta legal a esse fenômeno, apesar de avanços na legislação 4.0, enfrenta desafios devido à natureza anônima e descentralizada do comércio online. Estratégias eficazes para combater o tráfico de drogas nesse contexto emergente são necessárias, considerando os desafios legais, políticos e técnicos.
RELATO DE CASO: LESÃO CAPILAR TIPO HEMANGIOMA INTRAMUSCULAR (ICTH)/ MALFORMAÇÃO VASCULAR DE ALTO FLUXO INTRAMUSCULAR
Authors: Branco Fabio Eduardo Teixeira , Sales Marina Iser , Ikeda Augusto Kenzo Colombo
Published: December 2023

As anomalias vasculares intramusculares são de difícil diagnóstico e causadoras de dor crônica com grande impacto na mobilidade, principalmente quando acomete membros inferiores. A paciente do caso apresenta uma malformação vascular de alto fluxo no músculo gastrocnêmio, principalmente acometendo a cabeça medial, do lado esquerdo, com manifestação de marcha em equino e com câimbras fortes no período noturno associado a convulsões. Foram realizados diversos exames: O Ecodoppler colorido revelou alto fluxo na anomalia vascular e a ressonância magnética revelou tecido fibrótico com acúmulo adiposo adjacente ao músculo gastrocnêmio. Em uma primeira abordagem, foi realizada a embolização endovascular da anomalia, por três vezes utilizando ônix 18, sem melhora. Como havia lesão das fibras musculares do gastrocnêmio, foi optado pela remoção da musculatura e posterior alongamento do tendão de aquiles com órtese e fisioterapia motora. Hoje a paciente teve alta ambulatorial, com discreto déficit na deambulação e sem qualquer medicamento analgésico ou anti convulsivante.
COMPLIANCE NO DIREITO TRABALHISTA E AMBIENTE CORPORATIVO
Authors: Rios Helder Sampaio Fernandes , Rios Alexsandra Fernandes
Published: December 2023

O artigo em voga pretende trazer em seu bojo esclarecimentos e argumentos que permitam analisar criticamente a adoção dos procedimentos de compliance no ambiente de trabalho corporativo e quais as consequências efetivas nessa mudança no mundo empresarial. O compliance trabalhista é um tema bastante recente e que começa a gerar repercussões no mundo jurídico, as quais merecem ser debatidas por meio do presente artigo. Em suma, o presente artigo tem como objetivo fomentar o debate sobre a importante temática que cerca a adição dos processos de compliance e anti-corrupção no ambiente empresarial e sob a ótica do Direito do Trabalho. Ressalta-se o uso metodologico indutivo e o cartesiano, e os resultados expressos com base na lógica indutiva. Utilizou-se o método processual nas conclusões legais, doutrinárias e jurisprudenciais, bem como, métodos de pesquisa, categorias, conceitos operacionais e bibliografia. Os resultados esperados desta pesquisa demonstram como o uso do compliance em pode contribuir positivamente no ambiente corporativo, propocioando relacionamentos de trabalho mais saudáveis e éticos.
AUTOMEDICAÇÃO EM ESTUDANTES DE SAÚDE: UM PERIGO DA INFORMAÇÃO
Authors: Lopes Rafaela Ferreira , Muniz Claudia da Silva Ramos , Netto José Ferreira de Sousa
Published: December 2023

Objetivo: Demonstrar a prática da automedicação nos estudantes de saúde, correlacionando o conhecimento adquirido ao longo do curso e as condutas farmacológicas escolhidas. Revisão bibliográfica: O surgimento de medicamentos desde a antiguidade possibilitou no auxílio, na prevenção e cura de inúmeras comorbidades, porém atrelado a este fato veio o uso irracional de medicamentos, que é um fator também predominante entre estudantes de saúde. Uma das justificativas para este comportamento se deve ao fato dos mesmos possuírem conhecimento técnico e científico; além do que o ambiente universitário é um solo fértil para proliferação de transtornos tanto físicos como psicológicos. Considerações finais: A automedicação entre estudantes de saúde é uma prática corriqueira, tendo em vista que tal prática está atrelada ao conhecimento adquirido durante a graduação e que tal conduta poderá trazer problemas à saúde a curto, médio e longo prazo.
TRATAMENTO DO LÚPUS ERITEMATOSO SISTÊMICO: DA TERAPIA PRECOCE À IMUNOSSUPRESSÃO
Authors: Guerreiro Beatriz Santana Vaz , Guerreiro Natália de Santana Vaz
Published: December 2023

O trabalho objetiva compilar, na forma de Revisão de Literatura, os principais pontos do tratamento do Lúpus Eritematoso Sistêmico, tanto de doença iniciais, na forma de tratamento precoce para retardar a progressão da patologia, quanto de quadros graves, ou seja, com acometimento orgânico, já instaurados. Para tal, foi realizada pesquisa na base de dados PubMed, e após filtragem, foram selecionados 9 artigos para compor este artigo.
ENSINO DE BIOGEOGRAFIA E LITERATURA INFANTOJUVENIL – UMA EXPERIÊNCIA DIDÁTICA NO ENSINO MÉDIO COM O GÊNERO LÍRICO E IMAGENS
Authors: De Oliveira Rosália Caldas Sanábio , Tiago Fabiana da Conceição Pereira , De Oliveira Érico Anderson
Published: December 2023

Esta exposição externa o diálogo entre o gênero literário lírico e imagens da natureza, estampadas em dois livros infantojuvenis (Passarinhos do Brasil – poemas que voam e Árvores do Brasil – cada poema no seu galho – de Lalau e Laurabeatriz). As obras foram estudadas, interdisciplinarmente, nas disciplinas de Geografia e Biologia, refletindo e aprendendo a respeito do conteúdo comum – Biomas Brasileiros e Biodiversidade. Colocado em prática em quatro (4) turmas do 1º ano do Ensino Médio Integrado do CEFET – MG (Centro Federal de Educação Tecnológica de Minas Gerais). Assim, o cerne dessa intenção didática foi analisar o aporte da literatura infantojuvenil em sala de aula para uma aprendizagem significativa, nesse caso, unindo o gênero literário – poesia - com imagens, em dois belos textos lírico-visuais. Verificamos que os livros aplicados asseguraram uma leitura inspiradora, servindo de conexão entre a literatura e o aprofundamento arrazoado do tópico priorizado nesta proposta. Baseando-se no conceito de apropriação da leitura e da escrita pelo sujeito – letramento – como prática social, expandindo conhecimentos e competências dos discentes, em Magda Soares, Bakhtin e Vygotsky, particularmente.
The application of the Research-Action methodology in the context of New Media: Systematic Literature Review
Authors: Vieira Maria Júlia , Martins Dalila
Published: December 2023

The interest in New Media has been increasing in research areas due to the growing amount of information and the constant development of technology. The form of information consumption has become more and more comprehensive and accessible, making it increasingly easier for society to identify the best and fastest ways of intervention to obtain relevant information for educational and social growth. However, there are still models of content transmission that need to be adapted to certain places, audiences, and needs, which requires more studies to identify the problem and beyond this, recognition of cause and effect in order to propose improvements in the process of social development. To act on social and educational problems, the Action-Research methodology presents itself as a possible solution. This methodology is characterized by constant collaboration between researchers and stakeholders living in the context of the problem, and the redefinition of solutions until the final goal is reached. Critical group thinking is thus central to the successful development of solutions to the problem at hand. Thus, this systematic literature review aims to identify and analyze the research conducted around New Media, with the implementation of the Action Research methodology. The SCOPUS database was used for the analysis, in which eight articles were found, with a time interval between 2015 and 2022, that used and operationalized the practice of Action-Research methodology to achieve the proposed empirical objectives, cyclically redefining the implemented actions in a participatory action context. This systematic literature review, further explores different contexts and areas of study, with the implementation of Action-Research methodology in relevant problems that are presented and analyzed through a meta-analysis. In this follow-up, in the meta-analysis it was possible to verify the diversity of contexts in the new means in the use of the methodology, not being permanent the area of education. In addition, the use of the methodology generated new perspectives for development and the possibility of future studies on the problems that were being investigated.
Intentionality for better communication in minimally conscious AI design
Authors:   Integrative Neuroscience Initiative, Melbourne, Victoria, Australia 3145, Poznanski R.R. , Cacha L.A. ,   1Integrative Neuroscience Initiative, Melbourne, Victoria, Australia 3145, Sbitnev V.I. ,   Petersburg B.P. Konstantinov Nuclear Physics Institute, Gatchina, Russian Federation,   Department of Electrical Engineering and Computer Science, University of California, Berkeley, USA, Iannella N. , Parida S. ,   Silo AI, Lapinlahdenkatu 1C, 00180 Helsinki, Finland, Brandas E.J. ,   Department of Chemistry, Uppsala University, 751 21 Uppsala, Sweden, Achimowicz J.Z. ,   Warsaw Medical Academy, Faculty of Medicine, 01-043 Warsaw, Poland
Published: December 2023

Consciousness is the ability to have intentionality, which is a process that operates at various temporal scales. To qualify as conscious, an artificial device must express functionality capable of solving the Intrinsicality problem, where experienceable form or syntax gives rise to understanding 'meaning' as a noncontextual dynamic prior to language. This is suggestive of replacing the Hard Problem of consciousness to build conscious artificial intelligence (AI) Developing model emulations and exploring fundamental mechanisms of how machines understand meaning is central to the development of minimally conscious AI. It has been shown by Alemdar and colleagues [New insights into holonomic brain theory: implications for active consciousness. Journal of Multiscale Neuroscience 2 (2023), 159-168] that a framework for advancing artificial systems through understanding uncertainty derived from negentropic action to create intentional systems entails quantum-thermal fluctuations through informational channels instead of recognizing (cf., introspection) sensory cues through perceptual channels. Improving communication in conscious AI requires both software and hardware implementation. The software can be developed through the brain-machine interface of multiscale temporal processing, while hardware implementation can be done by creating energy flow using dipole-like hydrogen ion (proton) interactions in an artificial 'wetwire' protonic filament. Machine understanding can be achieved through memristors implemented in the protonic 'wetwire' filament embedded in a real-world device. This report presents a blueprint for the process, but it does not cover the algorithms or engineering aspects, which need to be conceptualized before minimally conscious AI can become operational.
Tratado de Cirugía General en Atención Primaria en Salud Tomo11
Authors: Plúa Marcillo William Eduardo , Tigselema Maquizaca Andrea Estefania , Crespo Zamora María Verónica , Núñez Acosta Santiago Fabricio , Bastidas Oviedo Carla Daniela , Fabara Salvador Franklin Santiago , Bonilla Morejón Oswaldo Israel , Vilatuña Fustillos Paul Ricardo , Durán Almeida Roberto Carlos , Guzmán Beltrán Almendra Coralía
Published: December 2023

El undécimo tomo del "Tratado de Cirugía General en Atención Primaria en Salud" constituye un valioso aporte a la comprensión y práctica de la cirugía en entornos de atención primaria. Este volumen, meticulosamente elaborado por un destacado equipo de expertos, se presenta como una obra esencial para médicos generales y profesionales de la salud que buscan ampliar sus conocimientos y habilidades en cirugía general.
Dermatología en la Práctica Médica General Vol. 5
Authors: Cushpa Quinapanta Erik Manuel , Guachi Criollo Adriana Ximena , Mendoza Ocampo Gregorio Alexander , Gómez Leiva Victor Andres , Reyes Alban Lourdes Michelle , Cárdenas Garófalo Lizbeth Leonor , Sánchez Durán Natasha Vanessa , Fiallo Rodríguez Milena Doménica , Guaman Criollo Jeanette Alexandra , Jiménez Solano Elizabeth Alexandra , Fienco Pérez Adelma Yadira
Published: December 2023

El quinto volumen de "Dermatología en la Práctica Médica General" se erige como una obra esencial que destaca por su enfoque práctico y su relevancia inmediata para los profesionales de la medicina general. Compilado por expertos en dermatología, este libro se presenta como una guía indispensable para médicos generales y clínicos interesados en fortalecer sus conocimientos en dermatología.