bluuebunny/crossref_metadata_2025 huggingface dataset:
Earthquake Characteristics and Structural Properties of the Southern Tyrrhenian Basin from Full Seismic Wave Simulations
Authors: Nardoni Chiara , De Siena Luca , Magrini Fabrizio , Cammarano Fabio , Maeda Takuto , Mattei Elisabetta
Published: February 2023

Modelling the response of seismic wavefields to sharp lateral variations in crustal discontinuities is essential for seismic tomography application and path effects correction in earthquake source characterization. This is particularly relevant when wavefields cross back-arc oceanic basins, i.e. mixed continental-oceanic settings. High-frequency (>0.05 Hz) seismic waves resonate and get absorbed across these settings due to a shallow Moho, crustal heterogeneities, and energy leakage. Here, we provide the first high-frequency wave-equation model of full seismograms propagating through realistic 3D back-arc basins. Inversion by parameters trial based on correlation analyses identifies P-, S- and coda-wave as attributes able to estimate jointly 3D Moho variations, sediment thickness, and earthquake source characteristics using data from a single regional earthquake. We use as data waveforms produced by the Accumoli earthquake (Central Italy, 2016), propagating across the Southern Tyrrhenian basin and recorded across Southern Italy. The best model comprises a deep Moho ($$\sim$$
∼
18 km) in the middle of the basin and a crustal pinch with the continental crust in Sicily. The deep Moho corresponds to the Issel Bridge, a portion of continental crust trapped between the Vavilov and Marsili volcanic centres. The Accumoli earthquake is optimally described at a depth of 7.3 km using a boxcar with rise time of 6 s. Our results show that the early S-wave coda comprises trapped and reverberating phases sensitive to crustal interfaces. Forward modelling these waves is computationally expensive; however, adding these attributes to tomographic procedures allows modelling both source and structural parameters across oceanic basins.
Real-World Evidence of Tolerability of 20% Subcutaneous Immunoglobulin Treatment
Authors: Rosenbach Kevin , Park Michelle , Sanchirico Marie , Nwose Oliseyenum , Paris Kenneth
Published: February 2023

Purpose

The safety and efficacy of subcutaneous immune globulin 20% (human) solution (Ig20Gly) were demonstrated in clinical trials. However, real-world evidence of the tolerability of self-administered Ig20Gly in elderly patients is lacking. We describe real-world patterns of Ig20Gly usage for 12 months in patients with primary immunodeficiency diseases (PIDD) in the USA.

Methods

This retrospective chart review of longitudinal data from 2 centers included patients aged ≥ 2 years with PIDD. Ig20Gly administration parameters, tolerability, and usage patterns were assessed at initial and subsequent 6- and 12-month infusions.

Results

Of 47 enrolled patients, 30 (63.8%) received immunoglobulin replacement therapy (IGRT) within 12 months before starting Ig20Gly, and 17 (36.2%) started IGRT de novo. Patients were predominantly White (89.1%), female (85.1%), and elderly (aged > 65 years, 68.1%; median age = 71.0 years). Most adults received at-home treatment during the study, and most self-administered at 6 months (90.0%) and 12 months (88.2%). Across all time points, infusions were administered at a mean rate of 60–90 mL/h/infusion, using a mean of 2 sites per infusion, on a weekly or biweekly frequency. No emergency department visits occurred, and hospital visits were rare (n = 1). Forty-six adverse drug reactions occurred in 36.4% of adults, mostly localized site reactions; none of these or any adverse events led to treatment discontinuation.

Conclusion

These findings demonstrate tolerability and successful self-administration of Ig20Gly in PIDD, including elderly patients and patients starting IGRT de novo.
Point of care transthoracic echocardiography for the prediction of post – spinal anesthesia hypotension in elderly patients with cardiac diseases and left ventricular dysfunction
Authors: Moschovaki Nefeli , Saranteas Theodosios , Spiliotaki Elen , Giannoulis Dimitrios , Anagnostopoulos Dimitrios , Talliou Christina , Milionis Orestis , Briassoulis Panagiotis , Katogiannis Konstantinos , Papadimos Thomas
Published: February 2023

In elderly patients with cardiac diseases, changes in cardiovascular physiology diminish cardiovascular reserve and predispose to hemodynamic instability after spinal anesthesia; hence, such patients could be at risk of postoperative complications. Additionally, transthoracic echocardiography (TTE) is used in clinical practice to evaluate cardiovascular hemodynamics. Therefore, we hypothesized that echocardiographic measurements could display significant diagnostic power in the prediction of post - spinal anesthesia hypotension in elderly patients with cardiac diseases and reduced left ventricular ejection fraction (LV-EF). Therefore, sixty-one elderly orthopedic-trauma patients were recruited. Prior to spinal anesthesia a TTE examination was performed. The LV-EF, the stroke volume index (SVI), the peripheral vascular resistance (PVR), the LV filling pressures (E/Em ratio), the right ventricular function [tricuspid annular plane systolic excursion (TAPSE), tricuspid annular systolic velocity (TASV) and fractional area change (FAC)], as well as inferior vena cava (IVC) measurements, such as IVCCI (collapsibility index of the IVC) and dIVCmax (maximum diameter of IVC)-to-IVCCI ratio were assessed. Twenty-six out of sixty-one patients manifested hypotension. Preoperative dIVCmax-to-IVCCI ratio demonstrated the greatest performance amongst echocardiographic indices in predicting post - spinal anesthesia hypotension. The dIVCmax-to-IVCCI ratio < 48 had significantly higher diagnostic power than IVCCI > 0.28, FAC > 42, E/Em ratio < 9 and SVI < 32 (receiver operator characteristic curve analysis). The gray zone for the dIVCmax-to-IVCCI ratio (40–49) showed the lowest number of inconclusive measurements among echocardiographic variables. The preoperative dIVCmax-to-IVCCI ratio could be a reliable echocardiographic index to predict post - spinal anesthesia hypotension in elderly patients with left ventricular dysfunction.
Web-Based Cognitive-Behavioral Therapy to Reduce Severe Cancer-Related Fatigue Among Survivors of Hodgkin Lymphoma: A Feasibility Study
Authors: Esser Peter , Müller Horst , Borchmann Peter , Kreissl Stefanie , Knoop Hans , Platzbecker Uwe , Vucinic Vladan , Mehnert-Theuerkauf Anja
Published: February 2023

We investigated the feasibility of a web-based cognitive-behavioral therapy to reduce cancer-related fatigue (CRF) among survivors of Hodgkin lymphoma. In this before-and-after trial, patients were primarily recruited via the German Hodgkin Study Group (GHSG). We assessed feasibility (response and drop-out rate) and preliminary efficacy including CRF, quality of life (QoL), and depressive symptomatology.Ttests compared baseline levels with t1 (post treatment) and t2 (3 months of follow-up). Among 79 patients contacted via the GHSG, 33 provided interest (42%). Among the seventeen participants, four were treated face-to-face (pilot patients), 13 underwent the web-based version. Ten patients completed the treatment (41%). Among all participants, CRF, depressive symptomatology, and QoL improved at t1 (p ≤ .03). The effect in one of the CRF measures remained at t2 (p = .03). Except for QoL, post-treatment effects were replicated among the completers of the web-based version (p ≤ .04). The potential for this program has been demonstrated, but needs to be re-assessed after identified issues on feasibility have been resolved.

Trial registration: The study was registered at ClinicalTrials.gov (Number: NCT03968250).
Green Constant-wavelength Concurrent Selective Fluorescence Method for Assay of Ibuprofen and Chlorzoxazone in Presence of Chlorzoxazone Degradation Product
Authors: Abdallah Nora A. , Fathy Mona E. , Tolba Manar M. , El-Brashy Amina M. , Ibrahim Fawzia A.
Published: February 2023

Lower back pain is a universal dilemma leaving a negative effect on both health and life quality. It was found that a fixed dose combination of chlorzoxazone and ibuprofen gave a higher efficiency than analgesic alone in treatment of acute lower back pain. Based on the significant benefit of that combination, a green, sensitive, rapid, direct, and cost-effective method is created for concurrent determination of ibuprofen and chlorzoxazone in presence of 2-amino para chlorophenol (a synthetic precursor and potential impurity of chlorzoxazone) adopting the synchronous spectrofluorimetric technique. Synchronous spectrofluorimetric technique is adopted to avoid the highly overlapped native spectra of both drugs. The synchronous spectrofluorometric method was applied at Δλ = 50 nm, ibuprofen was measured at 227 nm while chlorzoxazone was measured at 282 nm with no hindering from one to another. The various experimental variables affecting the performance of the suggested technique were explored and adjusted. The suggested technique showed good linearity from 0.02 to 0.6 and 0.1 to 5.0 µg/mL for ibuprofen and chlorzoxazone, respectively. The produced detection limits were 0.27 × 10–3and 0.03, while the quantitation limits were 0.82 × 10–3and 0.09 µg/mL for ibuprofen and chlorzoxazone, respectively. The suggested approach was successfully applied for the analysis of the studied drugs in the synthetic mixture, different pharmaceutical preparations, and spiked human plasma. The suggested technique was validated with respect to the International Council of Harmonization (ICH) recommendations. The suggested technique was found to be simpler and greener with lower cost compared to the earlier reported methods which required complicated techniques, longer time of analysis, and less safe solvents and reagents. Green profile assessment for the developed method compared with the reported spectrofluorometric method was performed using four assessment tools. These tools confirmed that the recommended technique attained the most possible green parameters, so it could be used as a greener option in routine quality control for analyzing the two drugs in genuine form and pharmaceutical preparations.
Second-Order Symmetric Duality for Multiple Objectives Nonlinear Programming Under Generalizations of Cone-Preinvexity Functions
Authors: Kassem Mohamed Abd El-Hady
Published: February 2023

In this article, we present generalizations of the cone-preinvexity functions and study a pair of second-order symmetric solutions for multiple objective nonlinear programming problems under these generalizations of the cone-preinvexity functions. In addition, we establish and prove the theorems of weak duality, strong duality, strict converse duality, and self-duality by assuming the skew-symmetric functions under these generalizations of the cone-preinvexity functions. Finally, we provide four nontrivial numerical examples to demonstrate that the results of the weak and strong duality theorems are true.
Unpacking an affordance-based model of chronic pain: a video game analogy
Authors: Coninx Sabrina , Ray B. Michael , Stilwell Peter
Published: February 2023

Chronic pain is one of the most disabling medical conditions globally, yet, to date, we lack a satisfying theoretical framework for research and clinical practice. Over the prior decades, several frameworks have been presented with biopsychosocial models as the most promising. However, in translation to clinical practice, these models are often applied in an overly reductionist manner, leaving much to be desired. In particular, they often fail to characterize the complexities and dynamics of the lived experience of chronic pain. Recently, an enactive, affordance-based approach has been proposed, opening up new ways to view chronic pain. This model characterizes how the persistence of pain alters a person’s field of affordances: the unfolding set of action possibilities that a person perceives as available to them. The affordance-based model provides a promising perspective on chronic pain as it allows for a systematic investigation of the interactive relation between patients and their environment, including characteristic alterations in the experience of their bodies and the space they inhabit. To help bridge the gap from philosophy to clinical practice, we unpack in this paper the core concepts of an affordance-based approach to chronic pain and their clinical implications, highlighting aspects that have so far received insufficient attention. We do so with an analogy to playing video games, as we consider such comparative illustration a useful tool to convey the complex concepts in an affordance-based model and further explore central aspects of the lived experience of chronic pain.
Qualities of consent: an enactive approach to making better sense
Authors: Vassilicos Basil , McGann Marek
Published: February 2023

Philosophical work on the concept of consent in the past few decades have got to grips with it as a rich notion. We are increasingly sensitive to consent not as a momentary, atomic, transactional thing, but as a complex idea admitting of various qualities and dimensions. In this paper we note that the recognition of this complexity demands a theoretical framework quite different to those presently extant, and we suggest that the enactive approach is one which offers significant value in this regard. In consonance with arguments made by Laurie Penny about how consent is a continuous and dynamic process, we outline how an enactive approach identifies consent as temporally extended (rather than momentarily transactional), and as affected by the skilfulness of the agents involved, the fitness of community-provided resources to negotiate the consensual relationship over time, and the unfolding of circumstances in the situation in which the joint action is taking place. We argue that the value of an enactive perspective on consent is in highlighting these complexities, and in providing resources to articulate and theorise them in ways that are not open to other current approaches.
Synthetic indicators to analyze work-related physical and psychosocial risk factors: evidence from the European Working Conditions Survey
Authors: Capecchi Stefania , Cappelli Carmela , Curtarelli Maurizio , Di Iorio Francesca
Published: February 2023

In modern workplaces, alongside physical, chemical, and biological hazards, other risks are linked to the organisation of work and to the nature of the work itself. This paper investigates the association between workers’ well-being and both psychosocial and physical risk factors at work proposing a synthetic measure suitable to generate insights on well-being at work and on individual risk factors. Exploiting data from the European Working Conditions Survey, we select as response variable the “self-assessed health”. As this proxy of well-being is measured on a Likert scale, Ordered Probit analyses are run, and respondents’ profiles are illustrated. Then, a Principal Component Analysis is carried out to build two synthetic measures summarising the selected risk determinants. The resulting first principal components are subsequently used as synthetic indicators in further, simplified, Ordered Probit models to explain the impact of different sets of risks on perceived health. Such a methodology allows for a straightforward interpretation of the results since many different risk drivers are replaced by two continuous synthetic indicators. Our findings, in line with existing research, confirm that both types of risk factors do exert a substantial impact on workers’ health, although the psychosocial determinants seem to be more prominent.
Seasonality and the female happiness paradox
Authors: Blanchflower David G. , Bryson Alex
Published: February 2023

Most studies tracking wellbeing do not collect data across all the months in a year. This leads to error in estimating gender differences in wellbeing for three reasons. First, there are seasonal patterns in wellbeing (particularly life satisfaction and happiness) which are gendered, so failure to account for those confounds estimates of gender differences over time. Second, studies fielded in discrete parts of the year cannot extrapolate to gender differences in other parts of the year. Making inferences about trends over time is particularly problematic when a survey changes its field survey dates across years. Third, without monthly data, surveys miss big shifts in wellbeing that occur for short periods. This is a problem because women’s wellbeing is more variable over short periods of time than men’s wellbeing. It also bounces back faster. We show that simply splitting the data by months in a happiness equation generates a positive male coefficient in one subset of months from September to January and a negative coefficient in months February to August. Such a split has no impact on the male coefficients in an anxiety equation. Months matter.
Treatment of localized prostate cancer in elderly patients: the role of partial cryoablation
Authors: Selvaggio Oscar , Finati Marco , Falagario Ugo Giovanni , Silecchia Giovanni , Recchia Marco , Checchia Andrea Alberto , Milillo Paola , Sanguedolce Francesca , Cindolo Luca , Busetto Gian Maria , Bettocchi Carlo , Cormio Luigi , Carrieri Giuseppe
Published: February 2023

Purpose

To evaluate oncological outcomes of partial gland cryoablation (PGC) for localized prostate cancer (PCa) in a cohort of elderly patients who required an active treatment.

Methods

Data from 110 consecutive patients treated with PGC for localized PCa were collected. All patients underwent the same standardized follow-up with serum-PSA level and digital rectal examination. Prostate MRI and eventual re-biopsy were performed at twelve months after cryotherapy or in case of suspicion of recurrence. Biochemical recurrence was defined according to Phoenix criteria (PSA nadir + 2 ng/ml). Kaplan–Meier curves and Multivariable Cox Regression analyses were used to predict disease progression, biochemical recurrence- (BCS) and additional treatment-free survival (TFS).

Results

Median age was 75 years (IQR 70–79). PGC was performed in 54 (49.1%) patients with low-risk PCa, 42 (38.1%) with intermediate risk and 14 (12.8%) high risk. At a median follow-up of 36 months, we recorded a BCS and TFS of 75 and 81%, respectively. At 5 years, BCS was 68.5% and CRS 71.5%.

High-risk prostate cancer was associated with lower TFS and BCS curves when compared with low-risk group (all p values < .03). A PSA reduction < 50% between preoperative level and nadir resulted as an independent failure predictor for all outcomes evaluated (all p values < .01). Age was not associated with worse outcomes.

Conclusions

PGC could be a valid treatment for low- to intermediate PCa in elderly patients, when a curative approach is suitable in terms of life expectancy and quality of life.
Long-Term Water Management Model for Preserving Sustainable Useful Capacity of Reservoirs
Authors: Molino Bruno , De Vincenzo Annamaria , Minó Antonio , Ambrosone Luigi
Published: February 2023

In this study, we present a long-term water management model which can be an important tool for the ordinary management of a reservoir. The model can be made simple and applicable in a graphic form. The key point of the model is that the sedimentation rate of solids can be modeled according to a power law. The basic equation of the model is tested using bathymetric surveys of different dams located in different parts of the world. Robustness and predictive power are evaluated both numerically and by comparison with satellite results. Then the model is transformed into the form of a management plot and applied to the real case of the Camastra dam.
A comprehensive study for Al2O3 nanofluid cooling effect on the electrical and thermal properties of polycrystalline solar panels in outdoor conditions
Authors: Ibrahim Ali , Ramadan Muhammad Raafat , Khallaf Abd EL-Monem , Abdulhamid Muhammad
Published: February 2023

Photovoltaic (PV) technology is considered one of the most effective and promising renewable sources of energy. The PV system’s efficiency strongly depends on its operating temperature, which acts as a defect to the electrical efficiency by increasing over 25 °C. In this work, a comparison was performed between three traditional polycrystalline solar panels simultaneously at the same time and under the same weather conditions. The electrical and thermal performances of the photovoltaic thermal (PVT) system integrated with a serpentine coil configured sheet with a plate thermal absorber setup are evaluated using water and aluminum oxide nanofluid. For higher mass flow rates and nanoparticle concentrations, an improvement in the PV modules short-circuit current (Isc) and open-circuit voltage (Voc) yield and electrical conversion efficiency is achieved. The enhancement in the PVT electrical conversion efficiency is 15.5%. For 0.05% volume concentration of Al2O3 and flow rate of 0.07 kg/s, an enhancement of 22.83% of the temperature of PVT panels’ surface over the reference panel has been obtained. An uncooled PVT system reached a maximum panel temperature of 75.5 °C at noontime and obtained an average electrical efficiency of 12.156%. Water and nanofluid cooling reduce the panel temperature by 10.0 °C and 20.0 °C at noontime, respectively.
Copper toxicity leads to accumulation of free amino acids and polyphenols in Phaeodactylum tricornutum diatoms
Authors: Santiago-Díaz Paula , Rivero Argimiro , Rico Milagros , González González Aridane , González-Dávila Melchor , Santana-Casiano Magdalena
Published: February 2023

This work is focused on the effect of lethal and sub-lethal copper (Cu) concentrations on the free amino acid and polyphenol production by the marine diatom Phaeodactylum tricornutum (P. tricornutum) after 12, 18, and 21 days of exposure. The concentrations of 10 amino acids (arginine, aspartic acid, glutamic acid, histidine, lysine, methionine, proline, valine, isoleucine, and phenylalanine) and 10 polyphenols (gallic acid, protocatechuic acid, p-coumaric acid, ferulic acid, catechin, vanillic acid, epicatechin syringic acid, rutin, and gentisic acid) were measured by RP-HPLC. Under lethal doses of Cu, free amino acids reached levels significantly higher than those in the control cells (up to 21.9 times higher), where histidine and methionine showed the highest increases (up to 37.4 and 65.8 times higher, respectively). The total phenolic content also increased up to 11.3 and 5.59 times higher compared to the reference cells, showing gallic acid the highest increase (45.8 times greater). The antioxidant activities of cells exposed to Cu were also enhanced with increasing doses of Cu(II). They were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ability (RSA), cupric ion reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays. Malonaldehyde (MDA) exhibited the same tendency: cells grown at the highest lethal Cu concentration yielded the highest MDA level. These findings reflect the involvement of amino acids and polyphenols in protective mechanisms to overcome the toxicity of copper in marine microalgae.

Graphical Abstract
Surgery assistance system for continuous resection of brain tumors-proposal of continuous tumor resection forceps, tumor cell separation, dehydration, and isolation mechanism
Authors: Koguchi Taro , Shimizu Funika , Nagame Tomohiro , Goto Yuka , Iwasaki Hikaru , Hanafusa Akihiko , Takagi Motoki , Mohamaddan Shahrol , Nomura Kenichi , Muragaki Yoshihiro , Iseki Hiroshi , Masamune Ken , Akitaya Toyohisa
Published: February 2023

The tumor resection ratio must be improved due the increased possibility of recurrence or malignancy. The purpose of this study was to develop a system that includes forceps with a continuous suction function and flow cytometry to diagnose the malignancy of the tumor for safe, accurate, and effective surgery. A newly developed continuous tumor resection forceps consists of a triple pipe structure, which enables continuous suction of the tumor by integrating the reflux water and suction system. The forceps includes tip opening/closure detection switch to control the adsorption and suction strength when tip is opened and closed. To perform accurate tumor diagnosis using flow cytometry, a filtering mechanism was developed for dehydrating reflux water from continuous suction forceps. In addition, a cell isolation mechanism comprising a roller pump and shear force loading mechanism was also newly developed. By using a triple pipe structure, a significantly larger tumor collection ratio was observed compared to the previous double-pipe structure. By performing suction pressure control with the opening/closure detection switch, inaccurate suction can be prevented. By widening the filter area of dehydration mechanism, it was possible to improve the reflux water dehydration ratio. The most appropriate filter area was 85 mm2. By using a newly developed cell isolation mechanism, the processing time can be reduced to less than 1/10 of the original time, keeping the same cell isolation ratio, when compared to the existing pipetting method. Neurosurgery assistance system with continuous tumor resection forceps and a cell separation, dehydration and isolation mechanism was developed. An effective and safe tumor resection, accurate and fast diagnosis of malignancy can be achieved by using the current system.
Der Kompass Digitalisierung
Authors: Kopp Ralf , Wienzek Tobias
Published: February 2023

Dieser Beitrag der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) stellt den Kompass Digitalisierung als soziotechnische Gestaltungshilfe für Führungskräfte im Kontext von Digitalisierungsvorhaben vor. Obwohl soziotechnische Forschung in den letzten Jahren im Zuge der Auseinandersetzung um Industrie 4.0 und KI eine kleine Renaissance erfahren hat, wurden bisher kaum soziotechnisch fundierte Führungskonzepte und hiermit verknüpfte Gestaltungshilfen entwickelt.

Unter der Prämisse, dass Führung im Kern eine Form der Interaktionsarbeit darstellt, werden Konturen eines solchen Konzeptes umrissen und mit der Skizzierung des Kompass Digitalisierung ein anschlussfähiges Instrument präsentiert, welches es Führungskräften bei Technikeinführungen ermöglicht Gestaltungsoptionen und ihre Konsequenzen für Arbeit frühzeitig in partizipativer Form erkenn- und bearbeitbar zu machen.
Soziotechnisches Assistenzsystem zur lernförderlichen Arbeitsgestaltung in der robotergestützten Montage
Authors: Albu-Schäffer Alin , Huchler Norbert , Kessler Ingmar , Lay Florian , Perzylo Alexander , Seidler Michael , Steinmetz Franz , Weitschat Roman
Published: February 2023

Dieser Beitrag der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) widmet sich der lernförderlichen Gestaltung eines roboterbasierten Assistenzsystems für industrielle Montagetätigkeiten. Individualisierte Produkte, kleinere Losgrößen und beschleunigte Prozesse sind Aspekte des digitalen Wandels in der industriellen Fertigung und Teil des Leitbilds einer flexiblen Produktion. Mensch-Roboter-Kollaboration und wissensbasiertes Engineering sind aktuelle Ansätze, um diesen Anforderungen gerecht zu werden. Dieser Artikel stellt an einem Anwendungsbeispiel (Verdrahtung von Schaltschränken) einen ersten Ansatz vor, wie mittels wissensbasierter Technologien (v. a. Ontologien und deren logische Interpretation) Vorschläge zur Arbeitszuteilung zwischen Menschen und Robotern sowohl nach ökonomischen als auch nach Kriterien der humanen Arbeitsgestaltung automatisiert erstellt werden können. Zum einen können für jede Aufgabe ihre Anforderungen mit den individuellen Fähigkeiten und Stärken der Beschäftigten sowie mit denen des kollaborativen Robotersystems in einem Mixed-Skill-Konzept nach betrieblichen Kennziffern (z. B. Zeit, Qualität) abgeglichen werden, um sich so einem optimalen Produktionsablauf anzunähern. Zum anderen können dabei Aspekte einer humanen Gestaltung der Mensch-Maschine-Interaktion (MMI) berücksichtigt werden, die vordringlich mit Blick auf Lernförderlichkeit zusammengeführt werden. Lernförderlichkeit in der MMI setzt Zeit, Handlungsräume und förderliche Inhalte voraus und ist zugleich eine zunehmende Notwendigkeit, um vorausschauend auf den dynamisierten Wandel von Arbeit zu reagieren. Denn gerade mit dem Technikeinsatz ist ein starker Tätigkeitswandel in Richtung Entscheidungsträger und Problemlöser verbunden, der neben Qualifizierung und Weiterbildung auch niedrigschwelliger, arbeitsintegrierter Lerngelegenheiten bedarf. Gerade die kollaborative Robotik als Schlüsseltechnologie der flexiblen Fertigung macht es nötig, neue Konzepte für die Organisation des hybriden Zusammenwirkens von Mensch und Roboter zu entwickeln. Im Folgenden wird aufbauend auf den grundlegenden Ansatz das Konzept eines technischen Demonstrators vorgestellt, welches entlang eines empirischen Fallbeispiels entwickelt wurde. Die prototypische, technische Umsetzung basiert auf einer Arbeitsumgebung mit einem Roboterarm und zugehörigen Werkzeugen, formalen semantischen Beschreibungen der Fähigkeiten und Tätigkeiten von Menschen und Robotern sowie einer intuitiven Benutzeroberfläche, unter anderem für die individuelle Anpassung der generierten Arbeitszuteilungen.
Negative effects of time autonomy in digital collaboration
Authors: Mander Rebekka , Antoni Conny H.
Published: February 2023

This article in the journal Group. Interaction. Organization (GIO) focuses on the effects of time autonomy on job-to-home spillover and emotional exhaustion when employees face high time pressure in digital collaboration. We assume time autonomy to strengthen rather than to buffer the detrimental indirect effects of high time pressure on emotional exhaustion via job-to-home spillover, and that high digital collaboration amplifies this effect even further. In a sample of N = 111 employees, we investigated this research question using conditional process analysis. Results support our assumptions as for high digital collaboration high time autonomy amplified the detrimental indirect effect of time pressure on emotional exhaustion via job-to-home spillover, whereas for low digital collaboration high time autonomy buffered this indirect effect. Thus, employees’ risk for emotional exhaustion is higher when time pressure, time autonomy and digital collaboration are high. Therefore, employees and leaders should carefully consider their choices concerning the use of time in the context of digital collaboration.
Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis
Authors: Tukacs Vanda , Mittli Dániel , Hunyadi-Gulyás Éva , Hlatky Dávid , Medzihradszky Katalin F. , Darula Zsuzsanna , Nyitrai Gabriella , Czurkó András , Juhász Gábor , Kardos József , Kékesi Katalin A.
Published: February 2023

Declining cerebral blood flow leads to chronic cerebral hypoperfusion which can induce neurodegenerative disorders, such as vascular dementia. The reduced energy supply of the brain impairs mitochondrial functions that could trigger further damaging cellular processes. We carried out stepwise bilateral common carotid occlusions on rats and investigated long-term mitochondrial, mitochondria-associated membrane (MAM), and cerebrospinal fluid (CSF) proteome changes. Samples were studied by gel-based and mass spectrometry-based proteomic analyses. We found 19, 35, and 12 significantly altered proteins in the mitochondria, MAM, and CSF, respectively. Most of the changed proteins were involved in protein turnover and import in all three sample types. We confirmed decreased levels of proteins involved in protein folding and amino acid catabolism, such as P4hb and Hibadh in the mitochondria by western blot. We detected reduced levels of several components of protein synthesis and degradation in the CSF as well as in the subcellular fractions, implying that hypoperfusion-induced altered protein turnover of brain tissue can be detected in the CSF by proteomic analysis.
Challenge and threat appraisal of entrepreneurial errors: a latent profile analysis and examination of coping responses
Authors: Kleine Anne-Kathrin , Schmitt Antje , Wisse Barbara M.
Published: February 2023

According to transactional stress theory (TST), the extent to which entrepreneurs cope with errors by engaging in error damage control or ruminating about disengaging from their business goals depends on whether they interpret action errors as predominantly challenging or threatening. Using latent profile analysis (LPA), the current study investigates the existence of latent profiles of challenge and threat appraisal of entrepreneurial errors and their relationship with error damage control and rumination about business goal disengagement in a sample of 649 entrepreneurs. The results identify five appraisal profiles characterized by different challenge and threat appraisal intensities. The levels of error damage control and rumination about business goal disengagement differed between the profiles. Specifically, entrepreneurs high in challenge and threat appraisal showed higher levels of both forms of coping than those low in appraisal. Entrepreneurs falling into a high challenge and low threat appraisal profile exhibited the lowest level of business goal disengagement. Still, they showed similar levels of error damage control to those high on challenge and threat appraisal. Implications for the further development of TST and the development of effective error management interventions are discussed.
Genom-Editierung ohne die DNA-Sequenz zu verändern — geht das?
Authors: Schönberg Pascal Y. , Ding Li , Buchholz Frank
Published: February 2023

Epigenetic genome engineering expands our capabilities from modifying the DNA sequence to controlling its regulation. It provides the ability to change epigenetic marks at defined genomic loci to control gene expression without the need for an intervention in the genetic code. This short review touches on current approaches of epigenetic editing with a focus on long-term gene silencing.
Nicht-codierende RNA als Regulator der Neurogenese
Authors: Schneider Marius , Becker Peter B.
Published: February 2023

Long, non-coding (Inc) RNAs emerge as crucial regulators of gene expression. Their ability to interact with DNA and protein mediates the recruitment of regulators to defined chromosomal loci. LncRNAs are particularly abundant in brain tissues where they are involved in cell specification. We described a novel lncRNA, RUS (RNA upstream to Slitrk3), which interacts with epigenetic regulators and contributes to shaping the gene expression program of neural precursor cells towards neurogenesis.
Vitamin A ist unerlässlich für die Funktion unserer Blutstammzellen
Authors: Rettkowski Jasmin , Mess Julian , Cabezas-Wallscheid Nina
Published: February 2023

Hematopoietic stem cells (HSCs) hold the unique capacity to restore the entire blood system throughout life. To preserve life-long stem cell functionality, metabolic, epigenetic and transcriptional drivers form complex regulatory networks to tightly regulate HSCs. This interplay can be controlled by single metabolites, especially vitamins, instructing those epigenetic and transcriptional attributes. A non-classical retinoic acid (RA) signaling axis has been shown to be indispensable for protection of stem cell features in HSCs.
Exploring children’s negotiation of meanings about “D” in 2D and 3D shapes in a year 5/6 New Zealand primary classroom
Authors: Sharma Shweta
Published: February 2023

The mathematical construct of dimension is one of the fundamental ideas for developing a sound understanding of two-dimensional (2D) and three-dimensional (3D) shapes. Yet, research in mathematics education has rarely explored children’s understanding of dimension in primary education. This paper explores how year 5/6 (9 to 11 years old) children construct and negotiate their meanings about dimension while engaging in classroom interactions about 2D and 3D shapes during geometry lessons in a New Zealand (NZ) English-medium multilingual primary classroom. Transcribed data of two key moments selected from six audiovisually recorded geometry lessons are presented. The findings suggest that children may use different discursive constructions—“another world”, “different ways to go”, and “flat vs fat”—to display their meanings about dimension. The findings also suggest that children and teacher participants may use prosodic features of their languages to interactionally construct the meanings of these discursive constructions. The paper discusses these findings in light of current research literature and offers a few implications for curriculum development and future research.
Diffusion of Geographical Indication Law in Vietnam: “Journey To The West”
Authors: Nguyen Sy Luong , Le Van Anh
Published: February 2023

For a long time, Vietnamese legislators and scholars did not discuss geographical indication (GI) law in depth despite its having been long established in the country. However, when Vietnam signed the EU-Vietnam Free Trade Agreement (EVFTA) in 2020, the tide turned: GIs now have a “VIP seat” in the treaty text. Without debating whether GIs have boosted local agriculture, this article discovers how and why the law has been transposed into Vietnamese law. To this end, we first accept Watson and Twining’s theories to presuppose legal transplant. Then, we employ five models surveyed by Morin and Gold to appraise how lawmakers adopt rules that might not always benefit the adopting country. We conclude that the EVFTA is a key influencer in disseminating the relevant policy, but that enforcement is far from successful.
Cooperative multi-agent target searching: a deep reinforcement learning approach based on parallel hindsight experience replay
Authors: Zhou Yi , Liu Zhixiang , Shi Huaguang , Li Si , Ning Nianwen , Liu Fuqiang , Gao Xiaozhi
Published: February 2023

Multi-agent multi-target search strategies can be utilized in complex scenarios such as post-disaster search and rescue by unmanned aerial vehicles. To solve the problem of fixed target and trajectory, the current multi-agent multi-target search strategies are mainly based on deep reinforcement learning (DRL). However, the training of agents by the DRL tend to be brittle due to their sensitivity to the training environment, which makes the strategies learned by the agents fall into local optima frequently, resulting in poor system robustness. Additionally, sparse rewards in DRL will lead to the problems such as difficulty in system convergence and low utilization efficiency of the sampled data. To address the problem that the robustness of the agents is weakened and the sparse rewards exist in the multi-objective search environment, we propose a MiniMax Multi-agent Deep Deterministic Policy Gradient based on the Parallel Hindsight Experience Replay (PHER-M3DDPG) algorithm, which adopts the framework of centralized training and decentralized execution in continuous action space. To enhance the system robustness, the PHER-M3DDPG algorithm employs a minimax learning architecture, which adaptively adjusts the learning strategy of agents by involving adversarial disturbances. In addition, to solve the sparse rewards problem, the PHER-M3DDPG algorithm adopts a parallel hindsight experience replay mechanism to increase the efficiency of data utilization by involving virtual learning targets and batch processing of the sampled data. Simulation results show that the PHER-M3DDPG algorithm outperforms the existing algorithms in terms of convergence speed and the task completion time in a multi-target search environment.
Ist eine analytische Geistesgeschichte möglich? Vier Thesen
Authors: Perler Dominik
Published: February 2023

Wie ist es möglich, philosophische Texte analytisch zu erschließen, gleichzeitig aber auch historisch zu kontextualisieren und dadurch analytische Geistesgeschichte zu betreiben? Der Text beantwortet diese Frage, indem er vier Thesen vorstellt. (1) Gemäß der Nominalismus-These müssen einzelne Texte, nicht etwa allgemeine Strömungen oder Ideen, in den Blick genommen werden. (2) Die Relationismus-These besagt, dass diese Texte stets zu anderen Texten in ihrem historischen Kontext in Beziehung zu setzen sind. (3) Die Multiperspektivismus-These betont, dass Texte in verschiedenen Kontexten zu berücksichtigen sind, sodass unterschiedliche Arten von Relationen deutlich werden. (4) Schließlich fordert die Historiographie-These, dass neben den Texten auch die Interpretationsschemata kritisch geprüft werden. Alle vier Thesen werden mit Bezug auf Texte der mittelalterlichen Philosophie erläutert.
A Review of Big Data in Road Freight Transport Modeling: Gaps and Potentials
Authors: Shoman Wasim , Yeh Sonia , Sprei Frances , Köhler Jonathan , Plötz Patrick , Todorov Yancho , Rantala Seppo , Speth Daniel
Published: February 2023

Road transport accounted for 20% of global total greenhouse gas emissions in 2020, of which 30% come from road freight transport (RFT). Modeling the modern challenges in RFT requires the integration of different freight modeling improvements in, e.g., traffic, demand, and energy modeling. Recent developments in 'Big Data' (i.e., vast quantities of structured and unstructured data) can provide useful information such as individual behaviors and activities in addition to aggregated patterns using conventional datasets. This paper summarizes the state of the art in analyzing Big Data sources concerning RFT by identifying key challenges and the current knowledge gaps. Various challenges, including organizational, privacy, technical expertise, and legal challenges, hinder the access and utilization of Big Data for RFT applications. We note that the environment for sharing data is still in its infancy. Improving access and use of Big Data will require political support to ensure all involved parties that their data will be safe and contribute positively toward a common goal, such as a more sustainable economy. We identify promising areas for future opportunities and research, including data collection and preparation, data analytics and utilization, and applications to support decision-making.
Anterior vertebral body tethering for adolescent idiopathic scoliosis associated with less early post-operative pain and shorter recovery compared with fusion
Authors: O’Donnell Jennifer M. , Gornitzky Alex L. , Wu Hao-Hua , Furie Kira S. , Diab Mohammad
Published: February 2023

Purpose

While posterior spinal instrumentation and fusion (PSIF) for severe adolescent idiopathic scoliosis (AIS) is the gold standard, anterior vertebral body tethering (AVBT) is becoming an alternative for select cases. Several studies have compared technical outcomes for these two procedures, but no studies have compared post-operative pain and recovery.

Methods

In this prospective cohort, we evaluated patients who underwent AVBT or PSIF for AIS for a period of 6 weeks after operation. Pre-operative curve data were obtained from the medical record. Post-operative pain and recovery were evaluated with pain scores, pain confidence scores, PROMIS scores for pain behavior, interference, and mobility, and functional milestones of opiate use, independence in activities of daily living (ADLs), and sleeping.

Results

The cohort included 9 patients who underwent AVBT and 22 who underwent PSIF, with a mean age of 13.7 years, 90% girls, and 77.4% white. The AVBT patients were younger (p = 0.03) and had fewer instrumented levels (p = 0.03). Results were significant for decreased pain scores at 2 and 6 weeks after operation (p = 0.004, and 0.030), decreased PROMIS pain behavior at all time points (p = 0.024, 0.049, and 0.001), decreased pain interference at 2 and 6 weeks post-operative (p = 0.012 and 0.009), increased PROMIS mobility scores at all time points (p = 0.036, 0.038, and 0.018), and faster time to functional milestones of weaning opiates, independence in ADLs, and sleep (p = 0.024, 0.049, and 0.001).

Conclusion

In this prospective cohort study, the early recovery period following AVBT for AIS is characterized by less pain, increased mobility, and faster recovery of functional milestones, compared with PSIF.

Level of evidence

IV.
Regulating lethal autonomous weapon systems: exploring the challenges of explainability and traceability
Authors: Christie Edward Hunter , Ertan Amy , Adomaitis Laurynas , Klaus Matthias
Published: February 2023

We explore existing political commitments by states regarding the development and use of lethal autonomous weapon systems. We carry out two background reviewing efforts, the first addressing ethical and legal framings and proposals from recent academic literature, the second addressing recent formal policy principles as endorsed by states, with a focus on the principles adopted by the United States Department of Defense and the North Atlantic Treaty Organization. We then develop two conceptual case studies. The first addresses the interrelated principles of explainability and traceability, leading to proposals for acceptable scope limitations to these principles. The second considers the topic of deception in warfare and how it may be viewed in the context of ethical principles for lethal autonomous weapon systems.
Warrior Churchmen of Medieval England, 1000-1250
Authors: Nakashian Craig M.
Published: February 2023

An examination of the actions of clerics in warfare in the eleventh and twelfth centuries, looking at the difference between their actions and prescriptions for behaviour.
Contact Heat in Magnetoencephalography: A Systematic Review
Authors: Graeme-Drury Thomas J. , Worthen Siân F. , Maden Michelle , Raphael Jon H. , Khan Salim , Vreugdenhil Martin , Duarte Rui V.
Published: February 2023

Background:

Contact heat is commonly used in experimental research to evoke brain activity, most frequently acquired with electroencephalography (EEG). Although magnetoencephalography (MEG) improves spatial resolution, using some contact heat stimulators with MEG can present methodological challenges. This systematic review assesses studies that utilise contact heat in MEG, their findings and possible directions for further research.

Methods:

Eight electronic databases were searched for relevant studies, in addition to the selected papers' reference lists, citations and ConnectedPapers maps. Best practice recommendations for systematic reviews were followed. Papers met inclusion criteria if they used MEG to record brain activity in conjunction with contact heat, regardless of stimulator equipment or paradigm.

Results:

Of 646 search results, seven studies met the inclusion criteria. Studies demonstrated effective electromagnetic artefact removal from MEG data, the ability to elicit affective anticipation and differences in deep brain stimulation responders. We identify contact heat stimulus parameters that should be reported in publications to ensure comparisons between data outcomes are consistent.

Conclusions:

Contact heat is a viable alternative to laser or electrical stimulation in experimental research, and methods exist to successfully mitigate any electromagnetic noise generated by PATHWAY CHEPS equipment – though there is a dearth of literature exploring the post-stimulus time window.