bluuebunny/crossref_metadata_2025 huggingface dataset:
Awareness of Onco-Physiotherapy among Urban Adult Population
Authors: Dekate Akanksha Yogeshwar , Ghodge Siddhi Vijay
Published: January 2023

Context:

Physiotherapy is a health-care profession concerned with human functions and movements and aims at maximizing its potential. Physiotherapy as profession specializes in various fields such as musculoskeletal, neurology, cardiorespiratory, community, sports, and oncology. Onco-physiotherapy is a new specialized branch which aims to resolve the impairments caused by cancer and its treatment regimes. However, the awareness of this specialized branch of physiotherapy in general population is lesser known.

Aim:

The objective is to assess awareness of onco-physiotherapy among urban adult population.

Settings and design:

Descriptive study on urban population

Methods and materials:

Self-administered questionnaire was made on Google forms with close-ended questions. The questionnaire was circulated among urban adult population with the age group between 18 and 60 years through social media for 2 weeks.

Statistical Analsysis Used:

Data were collected, tabulated on Google Spreadsheet and descriptive statistics applied.

Results:

Three hundred and twenty-three people who participated in this study which were in the age group of 18–60 years. Out of the total 323 respondents, 172 respondents were women and 151 were men. Majority of population, i.e., 64.1% were not aware about physiotherapy in cancer treatment. 46.4% population did not know when physiotherapy should be started in cancer patients. 9.5% population were not aware of onco-physiotherapy setup. The data reveals that there is a lack of awareness of onco-physiotherapy in urban adult population.

Conclusion:

Lack of awareness of onco-physiotherapy among urban adult population. Lack of referral system.
Transanal minimally invasive surgery - A single-center experience
Authors: Pangeni Anang , Imtiaz Mohammad Rafiz , Rai Sujata , Shrestha Ashish K , Basnyat Pradeep Singh
Published: January 2023

Background:

Transanal minimally invasive surgery (TAMIS) was described in the literature 10 years ago. This procedure requires laparoscopic technical skills. It has been well accepted widely worldwide. TAMIS has been applied to multiple procedures, including excision for rectal polyps and cancer, with acceptable outcomes. The study aimed to assess the outcomes of TAMIS in a large district general hospital.

Methodology:

A retrospective study on prospectively collected data on 52 consecutive patients of TAMIS performed in a single unit was conducted between May 2014 and February 2020. Data were collected on patient demographics, clinical diagnosis, peri-operative findings, pathological findings, adequacy of excision and complications. Patients were followed up as per the trust and national post-polypectomy guidelines.

Results:

Among the 52 patients, TAMIS procedures were completed in 50 patients, of which 31 were female. The procedure was successful in 96.5% but had to abandon in two cases. There was no conversion to another procedure. Pre-operative indications were rectal polyps and one case was an emergency TAMIS in a patient who was bleeding following incomplete colonoscopic polypectomy. The final histology reported that the majority were benign polyps (46), and only 11 cases were malignant. The median distance of the lesion from the anal verge was 6 cm (3–10 cm). The median operative time was 55 min (8–175 min). A total of 45 (77.5%) lesions were completely excised and had negative microscopic margins. Most patients (64%) were discharged home the same day. No complications were observed at a median follow-up of 20 months (6–48 months). There was no mortality.

Conclusions:

Our data suggest that TAMIS can be safely performed in a district general hospital for both benign and early rectal cancer. TAMIS was also able to control post-polypectomy bleeding and completion of rectal polypectomy. In selected cases, day-case TAMIS is safe and feasible.
Comparison of levetiracetam as second-line drug with fosphenytoin in convulsive status epilepticus among children
Authors: Anupama S , Poovazhagi V , Nisha R , Suresh Kumar S , Sathya J
Published: January 2023

Background:

Status epilepticus (SE) is the most common neurologic emergency in the pediatric age group often serious and life-threatening. Although newer drugs were used, morbidity and mortality are still high. This study was done to compare the efficacy of levetiracetam with the existing second-line drug fosphenytoin in the treatment of SE.

Subjects and Methods:

This was a prospective, randomized parallel group trial from Pediatric Intensive Care Unit of a Tertiary Care Institute. One hundred children were recruited according to the inclusion and exclusion criteria, 50 in fosphenytoin group and 50 in levetiracetam group. Two groups were compared with respect to clinical cessation of seizures, recurrence, adverse event, and outcome.

Results:

Male-to-female ratio was 1.45:1. Seizure were controlled in 37 (74%) in fosphenytoin group and 28 (56%) in levetiracetam group) (P = 0.059). The mean time for cessation of seizures was 11.16 ± 3.58 min in fosphenytoin group as compared to was 12.78 ± 3.07 min in levetiracetam group (P = 0.059) The seizure recurrence in first 24 h (18 [36%] vs. 12 [24%]) (P = 0.643) and development of shock (14 [28%] vs. 11 [22%]) (P = 0.488) was comparable in two groups. Overall mortality was 10 (20%) in fosphenytoin group as compared to 7 (14%) levetiracetam group (P = 0.281).

Conclusions:

Efficacy of intravenous levetiracetam is comparable to fosphenytoin as a second-line medication in the management of convulsive SE in children.
Therapeutics in paediatric genetic diseases: current and future landscape
Authors: Koh Ai Ling , Jamuar Saumya Shekhar
Published: January 2023

There are more than 7,000 paediatric genetic diseases (PGDs) but less than 5% have treatment options. Treatment strategies targeting different levels of the biological process of the disease have led to optimal health outcomes in a subset of patients with PGDs, where treatment is available. In the past 3 decades, there has been rapid advancement in the development of novel therapies, including gene therapy, for many PGDs. The therapeutic success of treatment relies heavily on knowledge of the genetic basis and the disease mechanism. Specifically, gene therapy has been shown to be effective in various clinical trials, and indeed, these trials have led to regulatory approvals, paving the way for gene therapies for other types of PGDs. In this review, we provide an overview of the treatment strategies and focus on some of the recent advancements in therapeutics for PGDs.
Application of emerging technologies for gut microbiome research
Authors: Kwa Wit Thun , Sundarajoo Saishreyas , Toh Kai Yee , Lee Jonathan
Published: January 2023

Microbiome is associated with a wide range of diseases. The gut microbiome is also a dynamic reflection of health status, which can be modified, thus representing great potential to exploit the mechanisms that influence human physiology. Recent years have seen a dramatic rise in gut microbiome studies, which has been enabled by the rapidly evolving high-throughput sequencing methods (i.e. 16S rRNA sequencing and shotgun sequencing). As the emerging technologies for microbiome research continue to evolve (i.e. metatranscriptomics, metabolomics, culturomics, synthetic biology), microbiome research has moved beyond phylogenetic descriptions and towards mechanistic analyses. In this review, we highlight different approaches to study the microbiome, in particular, the current limitations and future promise of these techniques. This review aims to provide clinicians with a framework for studying the microbiome, as well as to accelerate the adoption of these techniques in clinical practice.
Política, sanidad y desinformación: argumentos en Instagram de los partidos de extrema derecha europea sobre las vacunas contra la COVID-19
Authors: Sánchez-Castillo Sebastián , López-Olano Carlos , Peris-Blanes Àlvar
Published: January 2023

Introducción: En esta investigación se ha analizado el discurso visual en Instagram de los partidos de extrema derecha europeos de Italia, Alemania, Francia, España, Bélgica, Austria y Polonia sobre las vacunas contra la COVID-19 realizados durante 2021. El objetivo principal se ha centrado en descubrir el posicionamiento de estos partidos frente al proceso de vacunación contra el coronavirus y el empleo de estrategias o encuadres sesgados vinculados con la desinformación. Metodología: Se han analizado (N=1050) publicaciones de Instagram mediante un análisis de contenido visual. Los resultados evidencian que los partidos de extrema derecha europeos analizados no han empleado sus cuentas de Instagram para difundir estrategias sanitarias con las que paliar los efectos de la COVID-19. Resultados: Los contenidos difundidos han resultados ser individualistas y acordes con los ideales propios de cada partido. Salvo excepciones puntuales, en general todos los partidos han mostrado una posición neutra sin ser muy explícitos en sus posiciones. Discusión: Lo que revelan estos hallazgos es una inclinación para no realizar discursos determinantes que puedan hacerles perder votantes, a pesar de mantener una postura crítica que pretende ser alternativa a la oficial. Conclusiones: Sus discursos principales aluden a la falta de libertad individual, a la voluntariedad en la administración de la dosis, al rechazo de la vacunación a niños y a la negación ante el pasaporte COVID.
Factors Affecting the Security of Information Systems in Africa: A Literature Review
Authors: Lubua Edison Wazoel , Semlambo Adam Aloyce , Mkude Catherine G
Published: January 2023

This study determined factors affecting the security of Information Systems in Africa. Also, it established the quality of publications in the area of Information Security. The study is based on peer-reviewed publications conducted in Africa. The study adopted the mixed research approach. The study used a systematic literature review, with part of the analysis using descriptive analysis. In total, 70 papers formed the population of publications extracted in the area of Information Security. In addition, 37 papers had the quality to be included in the analysis of factors affecting Information Security. The study found that information Security factors are in four key categories: human factors, policy-related issues, work environment, and demographic factors. Overall, the work environment is the most reported category affecting the security of Information Systems in Africa. In addition, gender is the highest reported individual factor associated with the insecurity of Information Systems; female is the highly affected gender. Other factors include the lack of Information Security training, the unchecked level of trust, carelessness and poor security policies. The study recommends training programs, policy improvement and promoting behaviours that minimise exposure to attacks.
Only memories are captured, and only footprints are left. Understanding the perception of eco-friendly hotel and tourist buying behavior
Authors: Amr Yassin Cherouk
Published: January 2023

This study attempts to provide insight into consumer decision-making, which has become increasingly difficult to understand and anticipate in today's sustainable development environment. A lack of awareness of tourists' perceptions and attitudes toward eco-friendly advertising in the hotel industry may impede hotels' capacity to attract consumers' purchasing power and negatively influence expected consumer response. As a result, this research article adds to our understanding of people's attitudes toward recommended eco-friendly hotel advertisements and their impact on the unplanned purchase of eco-friendly tours. Structural equational modelling was used to understand the relations of the factors under consideration. The findings revealed that good attitudes regarding eco-friendly hotel ads influence consumer decision-making in buying unplanned eco-friendly services, influenced by informativeness and credibility as values perceived by eco-friendly hotels. This research has implications for tourists, marketers, hotel managers, promoters, and customers.
Full-deautonomisation of a class of second-order mappings in ancillary form
Authors: Grammaticos Basil , Willox Ralph
Published: January 2023

We present an application of the full-deautonomisation method to a class of secondorder mappings which, using an ancillary variable, can be cast into a form that greatly facilitates the study of their singularities. The ancillary approach was originally introduced to make it possible to construct discrete Painlevé equations associated with the affine Weyl group E (1) 8 by deautonomising a QRT mapping. The full-deautonomisation method has been shown to offer a practical technique for calculating the exact dynamical degree of a mapping, whereby allowing the detection of discrete integrability using only singularity analysis. We study the confinement property for a given singularity, for a wide class of mappings that includes the autonomous limit of the standard additive Painlevé equation with E (1) 8 symmetry. This leads to a class of non-autonomous mappings, which can be integrable or not, for which we obtain their exact dynamical degrees. The case of a non-confining singularity is also analysed and again we obtain the corresponding dynamical degrees.
Advancing height growth models for the improved forest reproductive material of the main tree species in Latvia
Authors: Zeltiņš Pauls , Šņepsts Guntars , Donis Jānis , Rieksts-Riekstiņš Raitis , Kangur Ahto , Jansons Āris
Published: January 2023

The breeding of economically important forest tree species in the Baltic Sea region has contributed notably to the availability of quality wood for bioeconomy. Accordingly, the altered stand dynamics of improved trees should be identified and incorporated in growth models to accurately reflect these gains. Such advanced models can be used for assessment of different alternatives, e.g. strategies for increased carbon sequestration.
We tested and modified dynamic forms of the King-Prodan height growth function based on the remeasured National Forest Inventory plots in Latvia to predict the growth of improved Scots pine, Norway spruce and silver birch forest reproductive material (FRM) categories ‘qualified’ and ‘tested’ using height measurements from progenies of 371, 390, and 690 open-pollinated families, respectively. Both categories had steeper growth trajectories at young age compared to an unmodified function. Growth of category ‘tested’ for pine and birch exceeded that of category ‘qualified’ across the modelled age range, while trajectories mainly overlapped for spruce on lower site indices. The functions with FRM category-specific multipliers more accurately reflect the actual growth of improved stands, advancing planning of timely management activities like thinning. The single model with category-specific set of multipliers may be easy applicable in practice or incorporated in growth simulators without increased complexity for end-users. However, the predictions are limited to the sites with medium and high site indices, where improved planting stock is typically used.
Keywords: GADA approach, dynamic modelling, tree breeding, FRM categories
Descriptive analysis of sleep quality and its determinants among rural population of coastal Karnataka
Authors: Sivanesan Saranya , Rao Chythra Raghavendra , Mallya Sneha Deepak , Kumar Uttam , Kamath Asha
Published: January 2023

Background: A good quality of sleep helps to maintain mood, memory and cognitive performance. Aim & Objective: To assess quality of sleep and its determinants among rural adults. Settings and Design: A community based cross sectional study was carried out in rural field practice area of a medical college Methods and Material: Pittsburg sleep quality index scale was used to assess quality of sleep. Semi-structured questionnaire was used to collect information from participants. Anthropometric and blood pressure measurements were taken. Statistical analysis used: Chi-square test was used to find out association between poor sleep and specific morbidities. Univariate and multivariate logistic regression was done to assess predictors of poor sleep. Results: Among the 614 study subjects, 60.3% had good sleep. Presence of morbidity was significantly associated with poor sleep [AOR=1.48; 95%CI=1.05-2.08]. Presence of a dark room, taking a bath or having milk before bed time were top reasons cited to be facilitating good sleep. Presence of mosquitoes, having young children or adolescent at home and vital events in last one year were reported to hinder good sleep. Conclusions: A sizeable proportion of rural adults have poor sleep. Presence of morbidity was a significant predictor of poor sleep.
Spermatic cord leiomyosarcoma in a young male: a case report and literature review
Authors: Nadeem Muhammad Sohaib , Kashif Ali Sarwar  , Ujala Ali
Published: January 2023

Spermatic cord Leiomyosarcoma is an extremely rare intrascrotal tumour. Owing to its rarity, no definitive management guidelines have been formulated as yet. The majority of published literature comprises of case reports or case series and show varying outcomes depending upon multiple patient- and disease-related factors. Almost all cases are older adults with majority in the sixth or seventh decades of life. It is commonly labelled as an indolent curable tumour if treated early by radical orchiectomy. The role of lymphadenectomy, adjuvant radiotherapy or chemotherapy is unclear.
This case report concerns a young 38-year-old man who suffered from a painless firm left hemiscrotal mass for the past two years. Ultrasonography showed an intrascrotal paratesticular mass. Metastatic workup was negative. Left radical orchiectomy was performed and histopathology of the surgical specimen revealed leiomyosarcoma of the spermatic cord.
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The uncertainty of Cholera epidemic
Authors: Afzal Zubia , Gull Abdul Rehman
Published: January 2023

No abstract for Letter to Editor required
Correlation between the University Librarians’ Information Literacy Skills and Research Support Services
Authors: Ali Sakhawat , Ahmed Shamshad , Latif Muhammad Tariq
Published: January 2023

The purpose of the current research is to determine the correlation between the Pakistani university librarians’ information literacy skills (ILSs) and their provided research support services (RSSs) to faculty/researchers. To collect data from the respondents a purposive sampling technique was used. A questionnaire was managed offline as well as online to collect data from 259 librarians of the universities of Pakistan. The tool consisted of eight dimensions of ILSs and four of RSSs. The Pearson correlation coefficient test was applied to gauge the strength of the correlation between ILSs and RSSs. The findings reveal that there is a strong positive significant correlation between all of the factors of ILSs and RSSs except for three sub-factors whose correlation is medium. The value of the overall correlation between ILSs and RSSs is r = .80 which indicates a strong positive significant correlation. The study reveals that ILSs of the university librarians are imperative and a precondition for offering better RSSs.
Information Seeking on the Web: An Empirical Analysis
Authors: Afzal Waseem
Published: January 2023

In the post-internet era, the Web has become a conventional Medium for information seeking. Due to the pervasive role of the web in information seeking many scholars have studied its different aspects. The purpose of this study is to further extend the scope of information seeking research by examining the role of the characteristics of the Web (e.g., ease of navigation, ease of searching), properties of information (e.g., organization of information, quality of information, amount of information), and demographic factors in information seeking on the Web. A survey questionnaire was used to collect data from participants at a regional university. Descriptive as well as inferential statistics were used to analyze the responses. Notable impact of demographics such as gender and age was found in the use of the Web for information seeking. Specifically, it was found that females used the Web for information surfing more than the male participants and also preferred more the availability of information in different media formats. Age was found to be a significant influencer in terms of the importance placed on properties of information (e.g., quality of information) and characterizes of the Web (e.g., ease of search). Contrary to the common perceptions, it was found that as knowledge about computers increased the importance placed on convenience in finding information on the Web decreased. Authoritative offline information sources were still considered highly important in information seeking. The findings of this study will inform research on information seeking and will help information professionals to better facilitate users’ seeking of information on the Web.
DINÂMICA ESPACIAL E TEMPORAL DA COBERTURA DO SOLO NA MICROBACIA E ZONA RIPÁRIA DO RIO ÁGUAS CLARAS, AMAZÔNIA OCIDENTAL, BRASIL
Authors: Morande da Silva Ueliton , De Oliveira Suelen , Batista Mendes de Alencar Juliane , Fulan João Ânderson , Janones da Rocha Karen , Costa Guaraná Araujo Emmanoella , Maia de Souza Emanuel Fernando , Schmidt Cavalheiro Wanderson Cleiton , Vendruscolo Jhony
Published: January 2023

A análise da dinâmica da cobertura do solo é fundamental para entender os padrões de uso e ocupação e, consequentemente, para selecionar as práticas de manejo visando a conservação dos recursos naturais. Assim, objetivou-se com este trabalho analisar a dinâmica espacial e temporal da cobertura do solo na microbacia e zona ripária do rio Águas Clara. Para a aquisição dos dados e elaboração dos mapas, foi utilizado o software QGIS 2.10.1 e imagens dos satélites Landsat 5 (1984 e 2006) e Landsat 8 (2022). A microbacia do rio Águas Claras tem área de 39,27 km2 e a zona ripária de 7,05 km2, e em ambas áreas prevalecia a cobertura de floresta nativa no ano de 1984 (59,36% e 60,57% das áreas totais, respectivamente), e com o passar do tempo ocorreu o crescimento constante da área de agropecuária, também em ambas áreas, chegando a ocupar 82,94% e 64,68% de suas áreas totais, respectivamente, no ano de 2022. Diante do atual cenário (2022), recomenda-se a adoção de práticas integradas para conciliar o desenvolvimento das atividades agropecuárias a longo prazo e a conservação dos recursos naturais (solo e água), rumo ao desenvolvimento sustentável. Dentre as práticas destacam-se a recuperação da vegetação nativa na zona ripária que está ocupada com agropecuária, uso do componente florestal nos sistemas produtivos (exemplos: sistemas agroflorestais, silvipastoris, agrossilvipastoris e reflorestamentos) e adoção de práticas conservacionistas (exemplos: manutenção da cobertura do solo, plantio em contorno, terraceamento e cordões de vegetação permanente).
Semantic networks in subjective traces, from the narratives of a trans collective
Authors: Otero Ortiz Andrés Felipe , Belalcázar John Gregory
Published: January 2023

The main objective of this research was to demonstrate the processes of subjectivity present in the narratives of a trans collective. These narratives were obtained through the audiovisual material generated by said group. These narratives had to do with the transition of their gender identities related to the sociocultural structure. Social network analysis (ARS) was used in this research. Semantic graphs were built using the atlas ti program. The study was structured in three levels. The first level was based on micro-relationships, in which the photographic content of the collective was considered, such as its relationships, subjectivity processes, and consolidation of subjective dimensions within the documentaries’ narratives (which were the central observation units). The second level referred to the complexity of what was evidenced in the first level. This second level considered violence due to prejudice, which gave an in-depth character to the relationships between the dimensions and the narratives. The third level delved into the macro relationships. All the relationships between the subjective and violent dimensions were presented. The results evidenced the inherent connections between the subjectivity of identities in transit with violence due to prejudice. It was visualized that violence (in its different forms) is part of the particular way in which trans people construct their gender identity. In addition, the processes of subjectivity were not developed separately but were presented simultaneously through audiovisual narratives.
Training program «How to preserve and support the mental health of educational personnel in war conditions»: content, structure, procedure.
Authors: Karamushka Liudmyla
Published: January 2023

The article presents the training program »How to preserve and support the mental health of educational personnel in war conditions». The author describes the program's objectives and training sessions («The Essence and Structure of Educational Staff's Mental Health», «Manifestations of the mental health of educational personnel in the conditions of war», «Educational Staff's Stress-Resistance in War Conditions»», «Educational Staff's Work Performance in War Conditions», «Educational Staff's Ability to Establish and Maintain Social Contacts in War Conditions» as well as the interactive techniques used in each session. Besides, the author analyzes the training sessions' procedure (protocols), the trainees' assigned tasks performance results and some mental health problems faced by educational staff and approaches to their solution.
IMPORTANCE OF ENVIRONMENTAL RESILIENCE TOWARDS SUSTAINABLE FUTURES: THE ACADEMIC WRITING IN POST-PANDEMIC TIMES
Authors: Esteves José Luiz
Published: January 2023

Responding to the invitation - more than honorable - to carry out the editorial of our International Journal of Environmental Resilience Research and Science - IJERRS at the end of 2022, has a broad, multidimensional and holistic meaning for me, which must promote the balance between responsibility, duty and gratitude.

The balance of RESPONSIBILITY, tacit and implicit, must point in the direction of meeting the wishes of an international network of researchers, the International Climate Resilience Research Network - RIPERC, the multigenerational, which consolidates and strengthens itself on the foundation of theory applied to practice, since, having laid its cornerstone in an event international milestone,  in September 2019, in a short time, starting from this "ground zero" as a structured collective, it brought to itself the noble perspective of promoting the deepening of knowledge that is as important as it is necessary, as it demonstrates the most present that we have at hand in the challenge of meeting to the urgent demands of Earth Sustainability, as it launched into the kaleidoscope of possible futures and that they are, as we preach daily in our meetings, works, thematic groups and teaching and professional practices, safer and more sustainable.
Sentiment Analysis on Airline Service Reviews using Data Mining based Classification Techniques
Authors: Rajat Yadu  , Ragini Shukla
Published: January 2023

Sentimental analysis is the field where online reviews, opinions, and sentiments from users are available and provide considerable amounts of information about the services, facilities, and status of the service provider in the market. In addition to examining the classification accuracy of standard data mining methods, this research evaluates the sentiments expressed about six social media microblog traveller networking site datasets relevant to Indian airlines. Using standard data mining classifiers, Bayes Net and SVM performed with high accuracy rates. In this paper main analysis of the classification performance of passenger sentiments for six airline services has been performed. However, we found that the Bayes Net performed best accuracy rate using WEKA tool but in case of using Rapid Miner tool SVM has produced the highest accuracy rate for our research among the other common standard classifiers. On the basis of thoroughly favourable service reviews from passengers, Go Air is consistently the airline that is most highly recommended.
Entre eficácias e riscos: controvérsias em torno da Cannabis no Brasil
Authors: Caetano Hellen
Published: January 2023

Em uma convergência entre Estudos Sociais das Ciências e Tecnologias e Antropologia da Saúde, sigo as controvérsias públicas que envolvem os procedimentos científicos e regulatórios com a Cannabis no Brasil, entre os anos de 2014-2019. Os diversos usos da Cannabis e seus derivados estão envoltos em controvérsias alimentadas por pesquisadores, Agência Nacional de Vigilância Sanitária, associações, pacientes e por ativistas. A análise antropológica apresentada foi construída a partir de um trabalho de campo que privilegiou documentos, artigos científicos e conteúdos disponíveis em mídias digitais, traçando a participação desses atores no desenvolvimento científico e tecnológico no País. A escolha do recorte temporal diz respeito às próprias mudanças regulatórias significativas com substâncias derivadas da Cannabis a partir de 2014, tomando-as diante de seus lugares ambíguos como “drogas” e “medicamentos”. Evidencio a importância de cada ator na manutenção dessas controvérsias que estão em constante movimento, instabilidade e mutação.
Pemanfaatan Game Edukasi Berbasis Mobile Untuk Meningkatkan Hasil Belajar Siswa
Authors: Darman
Published: January 2023

Tujuan dari penelitian ini adalah untuk mendeskripsikan peningkatan hasil belajar siswa melalui pemanfaatan game edukasi berbasis mobile. Metode yang digunakan dalam penelitian ini adalah penelitian tindakan kelas (PTK) yang bersifat reflektif, partisipatif, kolaboratif, dan spiral. Subjek dari penelitian ini adalah seluruh siswa kelas VII, 6 SMP Negeri 10 Kendari Kabupaten Kota Kendari dengan jumlah 20 orang siswa. Adapun faktor-faktor yang diteliti dalam penelitian ini, yaitu: 1) Faktor Siswa, untuk melihat tingkat keaktifan dan prestasi belajar siswa dalam pembelajaran ketika guru pemanfaatan game edukasi berbasis mobile, 2) Faktor Guru, untuk melihat kemampuan guru dalam pemanfaatan game edukasi berbasis mobile. Indikator keberhasilan dalam penelitian ini yaitu dengan cara menganalisis hasil tes siklus dengan menggunakan kriteria ketuntasan belajar. Siswa dikatan berhasil jika secara klasikal dari hasil analisis penilaian berdasarkan konversi nilai menunjukan pencapaian nilai minimal 75% dari indikator pembelajaran yang telah di tetapkan. Hasil Penelitian setelah dilakukan pengamatan diperoleh hasil belajar siswa siklus I sebanyak 50% (10 orang) siswa memiliki nilai > 75 dan meningkat pada siklus ke- II sebanyak 85% (17 orang) siswa memiliki > 75. Dengan demikian prestasi belajar siswa meningkat 15% pada siklus I dan siklus II 50% dengan pemanfaatan game edukasi berbasis mobile.
Ruxolitinib (Jakavi)
Authors: CADTH
Published: January 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.

The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.

This review assesses ruxolitinib (Jakavi), tablet 5 mg, 10 mg, 15 mg, 20 mg, oral.

Indication: The treatment of steroid-refractory (SR) or dependent acute graft-versus-host disease (aGvHD) in adults and children 12 years and older.
Measurement report: Long-range transport and the fate of dimethyl sulfide oxidation products in the free troposphere derived from observations at the high-altitude research station Chacaltaya (5240 m a.s.l.) in the Bolivian Andes
Authors: Scholz Wiebke , Shen Jiali , Aliaga Diego , Wu Cheng , Carbone Samara , Moreno Isabel , Zha Qiaozhi , Huang Wei , Heikkinen Liine , Jaffrezo Jean Luc , Uzu Gaelle , Partoll Eva , Leiminger Markus , Velarde Fernando , Laj Paolo , Ginot Patrick , Artaxo Paolo , Wiedensohler Alfred , Kulmala Markku , Mohr Claudia , Andrade Marcos , Sinclair Victoria , Bianchi Federico , Hansel Armin
Published: January 2023

Abstract. Dimethyl sulfide (DMS) is the primary natural contributor to the atmospheric sulfur burden. Observations concerning the fate of DMS oxidation products after long-range transport in the remote free troposphere are, however, sparse.
Here we present quantitative chemical ionization mass spectrometric measurements of DMS and its oxidation products sulfuric acid (H2SO4), methanesulfonic acid (MSA), dimethylsulfoxide (DMSO), dimethylsulfone (DMSO2), methanesulfinic acid (MSIA), methyl thioformate (MTF), methanesulfenic acid (MSEA, CH3SOH), and a compound of the likely structure CH3S(O)2OOH in the gas phase, as well as measurements of the sulfate and methanesulfonate aerosol mass fractions. The measurements were performed
at the Global Atmosphere Watch (GAW) station Chacaltaya in the Bolivian Andes located at 5240 m above sea level (a.s.l.). DMS and DMS oxidation products are brought to the Andean high-altitude station by Pacific air masses during the dry season after convective lifting over the remote Pacific ocean to 6000–8000 m a.s.l. and subsequent long-range transport in the free troposphere (FT).
Most of the DMS reaching the station is already converted to the rather unreactive sulfur reservoirs DMSO2 in the gas phase and methanesulfonate (MS−) in the particle phase, which carried nearly equal amounts of sulfur to the station. The particulate sulfate at Chacaltaya is however dominated by regional volcanic emissions during the time of the measurement and not significantly affected by the marine air masses.
In one of the FT events, even some DMS was observed next to reactive intermediates such as methyl thioformate, dimethylsulfoxide, and methanesulfinic acid. Also for this event, back trajectory calculations show that the air masses came from above the ocean (distance >330 km) with no local surface contacts.
This study demonstrates the potential impact of marine DMS emissions on the availability of sulfur-containing vapors in the remote free troposphere far away from the ocean.
Interactive stratospheric aerosol models' response to different amounts and altitudes of SO2 injection during the 1991 Pinatubo eruption
Authors: Quaglia Ilaria , Timmreck Claudia , Niemeier Ulrike , Visioni Daniele , Pitari Giovanni , Brodowsky Christina , Brühl Christoph , Dhomse Sandip S. , Franke Henning , Laakso Anton , Mann Graham W. , Rozanov Eugene , Sukhodolov Timofei
Published: January 2023

Abstract. A previous model intercomparison of the Tambora aerosol cloud has highlighted substantial differences among simulated volcanic aerosol properties in the pre-industrial stratosphere and has led to questions about the applicability of global aerosol models for large-magnitude explosive eruptions prior to the observational period.
Here, we compare the evolution of the stratospheric aerosol cloud following the well-observed June 1991 Mt. Pinatubo eruption simulated with six interactive stratospheric aerosol microphysics models to a range of observational data sets. Our primary focus is on the uncertainties regarding initial SO2 emission following the Pinatubo eruption, as prescribed in the Historical Eruptions SO2 Emission Assessment experiments (HErSEA), in the framework of the Interactive Stratospheric Aerosol Model Intercomparison Project (ISA-MIP). Six global models with interactive aerosol microphysics took part in this study: ECHAM6-SALSA, EMAC, ECHAM5-HAM, SOCOL-AERv2, ULAQ-CCM, and UM-UKCA. Model simulations are performed by varying the SO2 injection amount (ranging between 5 and 10 Tg S) and the altitude of injection (between 18–25 km). The comparisons show that all models consistently demonstrate faster reduction from the peak in sulfate mass burden in the tropical stratosphere. Most models also show a stronger transport towards the extratropics in the Northern Hemisphere, at the expense of the observed tropical confinement, suggesting a much weaker subtropical barrier in all the models, which results in a shorter e-folding time compared to the observations. Furthermore, simulations in which more than 5 Tg S in the form of SO2 is injected show an initial overestimation of the sulfate burden in the tropics and, in some models, in the Northern Hemisphere and a large surface area density a few months after the eruption compared to the values measured in the tropics and the in situ measurements over Laramie. This draws attention to the importance of including processes such as the ash injection for the removal of the initial SO2 and aerosol lofting through local heating.
Signatures of gravity wave-induced instabilities in balloon lidar soundings of polar mesospheric clouds
Authors: Kaifler Natalie , Kaifler Bernd , Rapp Markus , Fritts David C.
Published: January 2023

Abstract. The Balloon Lidar Experiment (BOLIDE), which was part of the Polar Mesospheric Cloud Turbulence (PMC Turbo) Balloon Mission has captured vertical profiles of PMCs during a 6 d flight along the Arctic circle in July 2018. The high-resolution soundings (20 m vertical and 10 s temporal resolution) reveal highly structured layers with large gradients in the volume backscatter coefficient. We systematically screen the BOLIDE dataset for small-scale variability by assessing these gradients at high resolution. We find longer tails of the probability density distributions of these gradients compared to a normal distribution, indicating intermittent behaviour. The high occurrence rate of large gradients is assessed in relation to the 15 min averaged layer brightness and the spectral power of short-period (5–62 min) gravity waves based on PMC layer altitude variations. We find that variability on small scales occurs during weak, moderate, and strong gravity wave activity. Layers with below-average brightness are less likely to show small-scale variability in conditions of strong gravity wave activity. We present and discuss the signatures of this small-scale variability, and possibly related dynamical processes, and identify potential cases for future case studies and modelling efforts.
Nitrite cycling in the primary nitrite maxima of the eastern tropical North Pacific
Authors: Travis Nicole M. , Kelly Colette L. , Mulholland Margaret R. , Casciotti Karen L.
Published: January 2023

Abstract. The primary nitrite maximum (PNM) is a ubiquitous feature of the
upper ocean, where nitrite accumulates in a sharp peak at the base of the
euphotic zone. This feature is situated where many chemical and hydrographic
properties have strong gradients and the activities of several microbial
processes overlap. Near the PNM, four major microbial processes are active
in nitrite cycling: ammonia oxidation, nitrite oxidation, nitrate reduction
and nitrite uptake. The first two processes are mediated by the nitrifying
archaeal/bacterial community, while the second two processes are primarily
conducted by phytoplankton. The overlapping spatial habitats and substrate
requirements for these microbes have made understanding the formation and
maintenance of the PNM difficult. In this work, we leverage high-resolution
nutrient and hydrographic data and direct rate measurements of the four
microbial processes to assess the controls on the PNM in the eastern
tropical North Pacific (ETNP). The depths of the nitrite maxima showed strong
correlations with several water column features (e.g., top of the
nitracline, top of the oxycline, depth of the chlorophyll maximum), whereas
the maximum concentration of nitrite correlated weakly with only a few water
column features (e.g., nitrate concentration at the nitrite maximum). The
balance between microbial production and consumption of nitrite was a poor
predictor of the concentration of the nitrite maximum, but rate measurements
showed that nitrification was a major source of nitrite in the ETNP, while
phytoplankton release occasionally accounted for large nitrite contributions
near the coast. The temporal mismatch between rate measurements and nitrite
standing stocks suggests that studies of the PNM across multiple timescales
are necessary.
Entrainment and deposition of boulders in a gravel bed river
Authors: Allemand Pascal , Lajeunesse Eric , Devauchelle Olivier , Langlois Vincent J.
Published: January 2023

Abstract. Bedload transport, entrainment of coarse sediment by a river, is inherently
a stochastic and intermittent process whose monitoring remains challenging.
Here, we propose a new method to characterize bedload transport in the
field. Using an uncrewed aerial vehicle (UAV) equipped with a high-resolution camera, we recorded yearly images of a bar of the Grande Rivière des Vieux-Habitants, a gravel bed river located on Basse-Terre Island (Guadeloupe, French West Indies). These images, combined with high-frequency measurements of the river discharge, allow us to monitor the evolution of the population of sediments of a diameter between 0.5 and 0.75 m on the riverbed. Based on this dataset, we estimate the smallest discharge that can move these boulders and calculate the duration of effective transport. We find that the transport of boulders occurs for approximately 10 h yr−1. When plotted as a function of the effective transport time, a given population of boulders decreases exponentially with an effective residence time of approximately 17 h. This exponential decay suggests that the probability of dislodging a grain from the bed is proportional to the number of grains at repose on the bed, an observation consistent with laboratory experiments. Finally, the residence time of bedload particles on a riverbed can be used to evaluate bedload discharge.
Improved soil evaporation remote sensing retrieval algorithms and associated uncertainty analysis on the Tibetan Plateau
Authors: Feng Jin , Zhang Ke , Zhan Huijie , Chao Lijun
Published: January 2023

Abstract. Actual evapotranspiration (ET) is the key link between water and energy cycles. However, accurate evaporation estimation in alpine barren areas remains understudied. In this study, we aimed to improve the satellite-driven Process-based Land Surface ET/Heat fluxes algorithm (P-LSH) for better satellite retrieval of ET on the Tibetan Plateau by introducing two effective soil moisture constraint schemes in which normalized surface soil moisture and the ratio of cumulative antecedent precipitation to cumulative antecedent equilibrium evaporation are used to represent soil water stress, respectively, based on the intercomparison and knowledge-learning of the existing schemes. We first conducted intercomparison of six existing soil evaporation algorithms and sorted out the two most effective soil moisture constraint schemes. We then introduced the modified versions of the two constraint schemes into the P-LSH algorithm and further optimized the parameters using the differential evolution method. As a result, it formed two improved P-LSH algorithms. We
systematically assessed the performances of the two improved P-LSH
algorithms and six existing remote sensing ET retrieval algorithms on two
barren-dominated basins of the Tibetan Plateau using reconstructed ET estimates derived from the terrestrial water balance method as a benchmark. The two moisture constraint schemes largely improved the performance of the P-LSH algorithm and showed better performance in both basins (root mean square error (RMSE) = 7.36 and 7.76 mm per month; R2=0.86 and 0.87), resulting in a higher simulation accuracy than all six existing algorithms. We used five soil moisture datasets and five precipitation datasets to further investigate the impact of moisture constraint uncertainty on the improved P-LSH algorithm. The ET estimates of the improved P-LSH algorithm, driven by the GLDAS_Noah soil moisture, performed best compared with those driven by other soil moisture and precipitation datasets, while ET estimates driven by various precipitation datasets generally showed a high and stable accuracy. These results suggest that high-quality soil moisture can optimally express moisture supply to ET, and that more accessible precipitation data can serve as a substitute for soil moisture as an indicator of moisture status for its
robust performance in barren evaporation.
Estimating karst groundwater recharge from soil moisture observations – a new method tested at the Swabian Alb, southwest Germany
Authors: Berthelin Romane , Olarinoye Tunde , Rinderer Michael , Mudarra Matías , Demand Dominic , Scheller Mirjam , Hartmann Andreas
Published: January 2023

Abstract. Understanding groundwater recharge processes is important for sustainable water resource management. Experimental approaches to study recharge in
karst areas often focus on analysing the aquifer response using a disintegration of its outlet signals, but only a few approaches directly investigate the
recharge processes that occur at the surface of the system. Soil moisture measurements have a high potential to investigate water infiltration to
deeper soil depth or epikarst with an easy and not too intrusive installation. They can yield long-term measurements with high temporal
resolution. Using these advantages, we developed and tested a method to estimate recharge based on soil moisture measurements. The method consists
of the extraction of linked events in rainfall, soil moisture, and discharge time series, as well as a subsequent fitting of the parameters of a simple
drainage model to calculate karst recharge from soil moisture metrics of individual events. The fitted parameters could be interpreted in physically
meaningful terms and were related to the properties of the karstic system. The model was tested and validated in a karst catchment located in
southwest Germany with hourly precipitation, soil moisture, and discharge data of 8 years duration. The soil moisture measurements were
distributed among grassland (n = 8) and woodland areas (n = 7) at 20 cm depth. A threshold of about 35 % (± 8 %) of
volumetric water content was necessary to initiate effective infiltration. Soil moisture averaged during the wetting period of each event was the
best metric for the prediction of recharge. The model performed reasonably well, estimating recharge during single rainfall events. It was also
capable of simulating 88 % of the average annual recharge volume despite considerable differences in the performance between years. The
event-based approach is potentially applicable to other karstic systems where soil moisture and precipitation measurements are available to predict
karst groundwater recharge.
Geoelectrical and hydro-chemical monitoring of karst formation at the laboratory scale
Authors: Rembert Flore , Léger Marie , Jougnot Damien , Luquot Linda
Published: January 2023

Abstract. Ensuring sustainable strategies to manage water resources in karst reservoirs requires a better understanding of the mechanisms responsible for conduits formation in the rock mass and the development of detection methods for these hydrological and geochemical processes. In this study, we monitored the electrical conductivity of two limestone core samples during controlled dissolution experiments. We interpret the results with a physics-based model describing the porous medium as effective structural parameters that are tortuosity and constrictivity. We obtain that constrictivity is more affected by calcite dissolution compared to tortuosity. Based on our experimental results and data sets from the literature, we show that the characteristic Johnson length is a valuable structural witness of calcite dissolution impact linking electrical and hydrological properties.