bluuebunny/crossref_metadata_2025 huggingface dataset:
Short regimen of rituximab plus lenalidomide in follicular lymphoma patients in need of first-line therapy
Authors: Zucca Emanuele , Rondeau Stephanie , Vanazzi Anna , Østenstad Bjørn , Mey Ulrich J. M. , Rauch Daniel , Wahlin Björn E. , Hitz Felicitas , Hernberg Micaela , Johansson Ann-Sofie , de Nully Brown Peter , Hagberg Hans , Ferreri Andrés J. M. , Lohri Andreas , Novak Urban , Zander Thilo , Bersvendsen Hanne , Bargetzi Mario , Mingrone Walter , Krasniqi Fatime , Dirnhofer Stefan , Hayoz Stefanie , Hawle Hanne , Vilei Simona Berardi , Ghielmini Michele , Kimby Eva
Published: May 2019

The SAKK 35/10 phase 2 trial, developed by the Swiss Group for Clinical Cancer Research and the Nordic Lymphoma Group, compared the activity of rituximab vs rituximab plus lenalidomide in untreated follicular lymphoma patients in need of systemic therapy. Patients were randomized to rituximab (375 mg/m2 IV on day 1 of weeks 1-4 and repeated during weeks 12-15 in responding patients) or rituximab (same schedule) in combination with lenalidomide (15 mg orally daily for 18 weeks). Primary end point was complete response (CR)/unconfirmed CR (CRu) rate at 6 months. In total, 77 patients were allocated to rituximab monotherapy and 77 to the combination (47% poor-risk Follicular Lymphoma International Prognostic Index score in each arm). A significantly higher CR/CRu rate at 6 months was documented in the combination arm by the investigators (36%; 95% confidence interval [CI], 26%-48% vs 25%; 95% CI, 16%-36%) and confirmed by an independent response review of computed tomography scans only (61%; 95% CI, 49%-72% vs 36%; 95% CI, 26%-48%). After a median follow-up of 4 years, significantly higher 30-month CR/CRu rates and longer progression-free survival (PFS) and time to next treatment (TTNT) were observed for the combination. Overall survival (OS) rates were similar in both arms (≥90%). Toxicity grade ≥3 was more common in the combination arm (56% vs 22% of patients), mainly represented by neutropenia (23% vs 7%). Addition of lenalidomide to rituximab significantly improved CR/CRu rates, PFS, and TTNT, with expected higher, but manageable toxicity. The excellent OS in both arms suggests that chemotherapy-free strategies should be further explored. This trial was registered at www.clinicaltrials.gov as #NCT01307605.
Identification and transcriptome analysis of erythroblastic island macrophages
Authors: Li Wei , Wang Yaomei , Zhao Huizhi , Zhang Huan , Xu Yuanlin , Wang Shihui , Guo Xinhua , Huang Yumin , Zhang Shijie , Han Yongshuai , Wu Xianfang , Rice Charles M. , Huang Gang , Gallagher Patrick G. , Mendelson Avital , Yazdanbakhsh Karina , Liu Jing , Chen Lixiang , An Xiuli
Published: May 2019

The erythroblastic island (EBI), composed of a central macrophage and surrounding erythroid cells, was the first hematopoietic niche discovered. The identity of EBI macrophages has thus far remained elusive. Given that Epo is essential for erythropoiesis and that Epor is expressed in numerous nonerythroid cells, we hypothesized that EBI macrophages express Epor so that Epo can act on both erythroid cells and EBI macrophages simultaneously to ensure efficient erythropoiesis. To test this notion, we used Epor-eGFPcre knockin mouse model. We show that in bone marrow (BM) and fetal liver, a subset of macrophages express Epor-eGFP. Imaging flow cytometry analyses revealed that >90% of native EBIs comprised F4/80+Epor-eGFP+ macrophages. Human fetal liver EBIs also comprised EPOR+ macrophages. Gene expression profiles of BM F4/80+Epor-eGFP+ macrophages suggest a specialized function in supporting erythropoiesis. Molecules known to be important for EBI macrophage function such as Vcam1, CD169, Mertk, and Dnase2α were highly expressed in F4/80+Epor-eGFP+ macrophages compared with F4/80+Epor-eGFP− macrophages. Key molecules involved in iron recycling were also highly expressed in BM F4/80+Epor-eGFP+ macrophages, suggesting that EBI macrophages may provide an iron source for erythropoiesis within this niche. Thus, we have characterized EBI macrophages in mouse and man. Our findings provide important resources for future studies of EBI macrophage function during normal as well as disordered erythropoiesis in hematologic diseases such as thalassemia, polycythemia vera, and myelodysplastic syndromes.
Recurrent MSCE116K mutations in ALK-negative anaplastic large cell lymphoma
Authors: Luchtel Rebecca A. , Zimmermann Michael T. , Hu Guangzhen , Dasari Surendra , Jiang Manli , Oishi Naoki , Jacobs Hailey K. , Zeng Yu , Hundal Tanya , Rech Karen L. , Ketterling Rhett P. , Lee Jeong-Heon , Eckloff Bruce W. , Yan Huihuang , Gaonkar Krutika S. , Tian Shulan , Ye Zhenqing , Kadin Marshall E. , Sidhu Jagmohan , Jiang Liuyan , Voss Jesse , Link Brian K. , Syrbu Sergei I. , Facchetti Fabio , Bennani N. Nora , Slager Susan L. , Ordog Tamas , Kocher Jean-Pierre , Cerhan James R. , Ansell Stephen M. , Feldman Andrew L.
Published: May 2019

Anaplastic large cell lymphomas (ALCLs) represent a relatively common group of T-cell non-Hodgkin lymphomas (T-NHLs) that are unified by similar pathologic features but demonstrate marked genetic heterogeneity. ALCLs are broadly classified as being anaplastic lymphoma kinase (ALK)+ or ALK−, based on the presence or absence of ALK rearrangements. Exome sequencing of 62 T-NHLs identified a previously unreported recurrent mutation in the musculin gene, MSCE116K, exclusively in ALK− ALCLs. Additional sequencing for a total of 238 T-NHLs confirmed the specificity of MSCE116K for ALK− ALCL and further demonstrated that 14 of 15 mutated cases (93%) had coexisting DUSP22 rearrangements. Musculin is a basic helix-loop-helix (bHLH) transcription factor that heterodimerizes with other bHLH proteins to regulate lymphocyte development. The E116K mutation localized to the DNA binding domain of musculin and permitted formation of musculin–bHLH heterodimers but prevented their binding to authentic target sequence. Functional analysis showed MSCE116K acted in a dominant-negative fashion, reversing wild-type musculin-induced repression of MYC and cell cycle inhibition. Chromatin immunoprecipitation–sequencing and transcriptome analysis identified the cell cycle regulatory gene E2F2 as a direct transcriptional target of musculin. MSCE116K reversed E2F2-induced cell cycle arrest and promoted expression of the CD30–IRF4–MYC axis, whereas its expression was reciprocally induced by binding of IRF4 to the MSC promoter. Finally, ALCL cells expressing MSCE116K were preferentially targeted by the BET inhibitor JQ1. These findings identify a novel recurrent MSC mutation as a key driver of the CD30–IRF4–MYC axis and cell cycle progression in a unique subset of ALCLs.
Winnicott: An Introduction
Authors: Phillips Adam
Published: May 2019

“Health is much more difficult to deal with than disease.” D. W. Winnicott

I

In a talk given in 1945 to the sixth form of St Paul's School, Donald Winnicott described his experience, as a schoolboy, of discovering Darwin'sOrigin of Species:

“I could not leave off reading it. At the time I did not know why it was so important to me, but I see now that the main thing was that it showed that living things could be examined scientifically with the corollary that gaps in knowledge and understanding need not scare me. For me this idea meant a great lessening of tension and consequently a release of energy for work and play.” (Quoted in Davis & Wallbridge, 1983, p. 24.)
Pre-morbid Psychopathology in Schizophrenia Spectrum
Authors: Parnas Josef , Jørgensen Aage
Published: May 2019

In a prospective, longitudinal study of high-risk offspring of schizophrenic mothers, of several dimensions of pre-morbid behaviour ‘peculiarity’ predicted subsequent schizophrenia or schizotypy. Peculiarity/eccentricity may represent a subtle marker of the schizophrenic genotype. ‘Pre-schizophrenics', as compared with ‘pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour.
Correlates of Positive and Negative Schizophrenic Syndromes in Nigerian Patients
Authors: Gureje O.
Published: May 2019

The two-syndrome concept of schizophrenia was investigated in a sample of 70 Nigerian schizophrenic patients. The positive and negative syndromes were studied in relation to demographic, historical, neurological and psychometric measures. The negative syndrome was associated with cognitive impairment, behavioural deterioration and left eye dominance, and also with poor pre-morbid educational achievement and longer length of current stay in hospital. The positive syndrome was unrelated to any of the independent variables. The two syndromes were not significantly related, supporting the view that they represent relatively independent dimensions of pathology. This provides further support for the validity of the Type I–Type II subtyping of schizophrenia in populations of patients from different cultural backgrounds, and suggests that the negative syndrome is related to the presence of neurodevelopmental deficits that possibly antedate the schizophrenic illness.
Prevalence of Childhood and Adolescent Depression in the Community
Authors: Fleming Jan E. , Offord David R. , Boyle Michael H.
Published: May 2019

Data from a cross-sectional community survey of 2852 children were used to provide estimates of the prevalence of a ‘DSM–III-like’ major depressive syndrome in children aged 6 to 16. The severity of symptoms required to define a ‘case’ was varied to generate three levels of diagnostic certainty (DC). The overall estimates of prevalence made with high DC were 0.6% for pre-adolescents and 1.8% for adolescents. Corresponding rates determined with medium DC were 2.7% and 7.8%, whereas the figures for low DC were 17.5% and 43.9%. Utilisation of mental health and social services, comorbidity (combined disorders), poor school performance, problems in getting along with others and need for professional help all increased as diagnostic certainty increased. There was wide disagreement in data supplied by the different groups of respondents, i.e. parents, teachers and adolescents.
Season of Birth in Alzheimer's Disease
Authors: Philpot Michael , Rottenstein Michelle , Burns Alistair , Der Geoffrey
Published: May 2019

Variation in quarter of birth was examined in patients with a clinical diagnosis of AD. There was a significant excess of first-quarter births among AD patients as compared with the expected birth rates derived from an age-matched census sample. This finding was due entirely to the significant excess of first-quarter births in AD patients without a family history of dementia. No seasonal variation was found in the birth dates of other clinical groups.
Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients
Authors: Flaskos J. , Theophilopoulos N. , George A. J.
Published: May 2019

Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.
Is Your ‘Double-Blind’ Design Truly Double-Blind?
Authors: Oxtoby Alison , Jones Angela , Robinson Michael
Published: May 2019

Before a drug trial, researchers reasonably plan that participants will remain ignorant of which drug each patient is taking, reflected in the use of allegedly identical preparations. However, only rarely is this plan subjected to systematic scrutiny after the event, and our point of view is that this is unsatisfactory.
Abnormal Involuntary Movements
Authors: Green Benjamin Hugh
Published: May 2019

The differential diagnosis of an athetoid arm movement in a 54-year-old lady with a psychiatric history of affective disorder was discussed. Further investigations after the conference yielded a firm diagnosis that unified both physical and mental symptoms.
An Acute Care for Elders Quality Improvement Program for Complex, High‐Cost Patients Yields Savings for the System
Authors: Brennan Maura J , Knee Alexander B , Leahy Erin J , Ehresman Michael J , Courtney Heidi‐Ann , Coffelt Patricia , Stefan Mihaela S
Published: May 2019

BACKGROUND

Acute Care for Elders (ACE) programs improve outcomes for older adults; however, little is known about whether impact varies with comorbidity severity.

OBJECTIVE

To describe differences in hospital‐level outcomes between ACE and routine care across various levels of comorbidity burden.

DESIGN

Cross‐sectional quality improvement study.

SETTING

A 716‐bed teaching hospital.

PARTICIPANTS

Medical inpatients aged ≥70 years hospitalized between September 2014 and August 2017.

INTERVENTION

ACE care, including interprofessional rounds, geriatric syndromes screening, and care protocols, in an environment prepared for elders

MEASUREMENTS

Total cost, length of stay (LOS), and 30‐day readmissions. We calculated median differences for cost and LOS between ACE and usual care and explored variations across the distribution of outcomes at the 25th, 50th, 75th and 90th percentiles. Results were also stratified across quartiles of the combined comorbidity score.

RESULTS

A total of 1,429 ACE and 10,159 non‐ACE patients were included in this study. The mean age was 81 years, 57% were female, and 81% were white. ACE patients had lower costs associated with care ranging from $171 at the 25th percentile to $3,687 at the 90th percentile, as well as lower LOS ranging from 0 days at the 25th percentile to 1.9 days at the 90th percentile. After stratifying by comorbidity score, the greatest differences in outcomes were among those with higher scores. There was no difference in 30‐day readmission between the groups.

CONCLUSION

The greatest reductions in cost and LOS were in patients with greater comorbidity scores. Risk stratification may help hospitals prioritize admissions to ACE units to maximize the impact of the more intensive intervention.
Achievable Benchmarks of Care for Pediatric Readmissions
Authors: Montalbano Amanda , Quiñonez Ricardo A , Hall Matt , Morse Rustin , Ishman Stacey L , Antoon James W , Gold Jessica , Teufel Ronald J , MD Vineeta Mittal , Shah Samir S , Parikh Kavita
Published: May 2019

BACKGROUND

Most inpatient care for children occurs outside tertiary children's hospitals, yet these facilities often dictate quality metrics. Our objective was to calculate the mean readmission rates and the Achievable Benchmarks of Care (ABCs) for pediatric diagnoses by different hospital types: metropolitan teaching, metropolitan nonteaching, and nonmetropolitan hospitals.

METHODS

We used a cross‐sectional retrospective study of 30‐day, all‐cause, same‐hospital readmission of patients less than 18 years old using the 2014 Healthcare Utilization Project National Readmission Database. For each hospital type, we calculated the mean readmission rates and corresponding ABCs for the 17 most common readmission diagnoses. We define outlier as any hospital whose readmission rate fell outside the 95% CI for an ABC within their hospital type.

RESULTS

We analyzed 690,949 discharges at 525 metropolitan teaching hospitals (550,039 discharges), 552 metropolitan nonteaching hospitals (97,207 discharges), and 587 nonmetropolitan hospitals (43,703 discharges). Variation in readmission rates existed among hospital types; however, sickle cell disease (SCD) had the highest readmission rate and ABC across all hospital types: metropolitan teaching hospitals 15.7% (ABC 7.0%), metropolitan nonteaching 14.7% (ABC 2.6%), and nonmetropolitan 12.8% (ABC not calculated). For diagnoses in which ABCs were available, outliers were prominent in bipolar disorders, major depressive disorders, and SCD.

CONCLUSIONS

ABCs based on hospital type may serve as a better metric to explain case‐mix variation among different hospital types in pediatric inpatient care. The mean rates and ABCs for SCD and mental health disorders were much higher and with more outlier hospitals, which indicate high‐value targets for quality improvement.
How Much Time are Physicians and Nurses Spending Together at the Patient Bedside?
Authors: Sang Adam X , Tisdale Rebecca L , Nielsen Derek , Loica‐Mersa Silvia , Miller Travis , Chong Ian , Shieh Lisa
Published: May 2019

BACKGROUND

Bedside rounding involving both nurses and physicians has numerous benefits for patients and staff. However, precise quantitative data on the current extent of physician–nurse (MD–RN) overlap at the patient bedside are lacking.

OBJECTIVE

This study aimed to examine the frequency of nurse and physician overlap at the patient beside and what factors affect this frequency.

DESIGN

This is a prospective, observational study of time‐motion data generated from wearable radio frequency identification (RFID)‐based locator technology.

SETTING

Single‐institution academic hospital.

MEASUREMENTS

The length of physician rounds, frequency of rounds that include nurses simultaneously at the bedside, and length of MD–RN overlap were measured and analyzed by ward, day of week, and distance between patient room and nursing station.

RESULTS

A total of 739 MD rounding events were captured over 90 consecutive days. Of these events, 267 took place in single‐bed patient rooms. The frequency of MD–RN overlap was 30.0%, and there was no statistical difference between the three wards studied. Overall, the average length of all MD rounds was 7.31 ± 0.58 minutes, but rounding involving a bedside nurse lasted longer than rounds with MDs alone (9.56 vs 5.68 minutes, P < .05). There was no difference in either the length of rounds or the frequency of MD–RN overlap between weekdays and weekends. Finally, patient rooms located farther away from the nursing station had a lower likelihood of MD–RN overlap (Pearson's r = –0.67, P < .05).

CONCLUSION

RFID‐based technology provides precise, automated, and high‐throughput time‐motion data to capture nurse and physician activity. At our institution, 30.0% of rounds involve a bedside nurse, highlighting a potential barrier to bedside interdisciplinary rounding.
A Decision Support System for Empty Hopper Car Management
Authors: Freeman Nickolas K. , Narayanan Arunachalam , Burns Gary P.
Published: May 2019

The authors developed a data-driven decision support system to improve a large U.S. chemical manufacturer’s management of its inventory of empty hopper cars. The system is providing the company with increased visibility into its supply chain and allowing it to make probabilistic business decisions.
Supply Chain Proximity and Product Quality
Authors: Bray Robert L. , Serpa Juan Camilo , Colak Ahmet
Published: May 2019

We estimate the effect of supply chain proximity on product quality. Merging four automotive data sets, we create a supply chain sample that reports the failure rate of 27,807 auto components, the location of 529 upstream component factories, and the location of 275 downstream assembly plants. We find that defect rates are higher when upstream and downstream factories are farther apart. Specifically, we estimate that increasing the distance between an upstream component factory and a downstream assembly plant by an order of magnitude increases the component’s expected defect rate by 3.9%. We find that quality improves more slowly across geographically dispersed supply chains. We also find that supply chain distance is more detrimental to quality when automakers produce early-generation models or high-end products, when they buy components with more complex configurations, or when they source from suppliers who invest relatively little in research and development.

This paper was accepted by Vishal Gaur, operations management.
Get Noticed and Die Trying: Signals, Sacrifice, and the Production of Face Time in Distributed Work
Authors: Cristea Ioana C. , Leonardi Paul M.
Published: May 2019

Research shows that displaying face time—being observed by others at work—leads to many positive outcomes for employees. Drawing on this prior work, we argue that face time helps employees to receive better work and leads to career advancement because it is a strong signal of their commitment to their job, their team, and their organization. But when employees are geographically distributed from managers who control the assignment of work, they are often unable to display face time. To compensate, employees must engage in other behaviors that signal commitment. Our study of two large, globally distributed, product-development companies demonstrates that employees who engage in certain behaviors can effectively signal their commitment to the organization and, as a consequence, will receive better work assignments. But because they operate in a competitive signaling environment, they have to continually engage in the behaviors that produce desired signals to the point where they often feel that they are sacrificing their personal lives for their job. We induct a model from our data that explains why simple behaviors that signal commitment eventually turn into feelings of sacrifice and why employees at headquarters who have the power to assign better work fail to notice the sacrifice behind the signals. We discuss the implications of this model and the signal misalignment it explains for theories of distributed work and signaling in organizations.

The online appendix is available at https://doi.org/10.1287/orsc.2018.1265 .
Conscious sedation and reduction of fractures in the paediatric population: An orthopaedic perspective
Authors: Yang B. W. , Waters P. M.
Published: May 2019

Purpose

Closed reduction under conscious sedation in the emergency department (ED) has been demonstrated to provide cost-effective, timely care. There has been little research into the efficacy of conscious sedation and reduction from an orthopaedic trauma perspective. This study describes the epidemiology and outcomes associated with fracture conscious sedation and reduction in our level I paediatric ED.

Methods

All fracture patients presenting overnight to our level I trauma centre ED between 01 June 2016 and 30 June 2017 were identified. Patient records were reviewed to determine diagnoses, treatments and outcomes. The rate of repeat intervention after successful conscious sedation and reduction and rate of changes in management in which the orthopaedic resident's overnight management plan to provide procedural sedation was altered to surgical intervention after morning case review rounds was calculated.

Results

Conscious sedation and reduction was performed on a total of 386 patients covering ten fracture types during the course of our study, with distal radius fractures (n = 167, 43.3%) comprising the majority of cases. A total of 53 cases (13.7%, 53/386) lost alignment and required repeat intervention, consisting of 33 cases (8.5%, 33/386) that required repeat surgery and 5.2% (20/386) that required cast wedging. In all, 12 patients (3.1%, 12/386) initially reduced under conscious sedation required a change in management and surgical intervention. There were five cases of growth arrest and two cases of malunion.

Conclusions

Conscious sedation and reduction provides an alternative to general anaesthesia for many paediatric trauma injuries without compromising patient outcomes

Level of Evidence

IV
Monitoramento do nível freático na área da Refinaria Abreu e Lima – Ipojuca-PE
Authors: Batista Ana Gabriella dos Santos , Demétrio José Geilson Alves
Published: May 2019

O monitoramento da variação da superfície potenciométrica de um aquífero é uma atividade fundamental para a compreensão do comportamento hidrodinâmico do mesmo. A Refinaria Abreu e Lima, conforme estabelecido no EIA/RIMA, vem realizando o monitoramento do aquífero freático, em sete poços de monitoramento, nos domínios de suas instalações, desde de maio de 2009. Infelizmente esse monitoramento não foi contínuo, principalmente porque alguns poços foram danificados, mas o volume de informações obtido foi substancial, principalmente nos dois anos de monitoramento automático, com registro horário dos níveis de água. Os dados de variação do nível da água, confrontados com os dados de precipitação, mostraram que o nível da água no aquífero está intimamente ligado ao regime das chuvas, com respostas bastante rápidas, sendo o pico de chuva defasado em doze horas do pico de subida da água no poço. Também foi feita uma análise das variações dos níveis estáticos com as variações da condutividade hidráulica do aquífero, determinada por Slug teste. As oscilações dos níveis da água nos ficaram entre 2,0 e 5,0 metros.
Avaliação da qualidade da água no Rio Grande no segmento entre estação de tratamento de esgoto do município de Barreiras – BA
Authors: Moura Alexandre Varão , Da SIlva Pamela Gabriele Feitoza , Das Virges Carolaine Santos , Soares Ana Paula Albernaz , Do Rego Enoc Lima
Published: May 2019

A ingestão frequente de água contendo concentração de flúor acima do limite estabelecido pela legislação brasileira causa uma doença chamada fluorose dentária. Atualmente, o monitoramento do nível de flúor na água para consumo humano é realizado utilizando métodos potenciométricos, cromatográficos ou colorimétricos, que são relativamente caros e utilizam equipamentos de difícil deslocamento para análises de campo. Portanto, surge a necessidade de desenvolver métodos alternativos, visando rapidez, praticidade, mobilidade e redução do custo das análises. O aplicativo para smartphone PhotoMetrix® é um software livre de análise de imagens digitais utilizando modelos matemáticos univariados e multivariados. A captura de imagens pode ser feita através do próprio smartphone ou com uma câmera USB externa. Assim, o objetivo deste estudo foi avaliar o uso do PhotoMetrix® no monitoramento da concentração de flúor em águas de abastecimento. Dois métodos de referência foram utilizados para comparação dos resultados: o método espectrofotométrico e o eletrodo de íon seletivos. Os resultados indicaram concordância entre os métodos, mostrando um coeficiente de determinação (R2) de 0,995 e erro de predição RMSEP (Root Mean Square Error of Prediction) de aproximadamente 0,05 mg L-1. Então, o PhotoMetrix® é um método satisfatório para a determinação de flúor, podendo se tornar uma alternativa viável para o monitoramento da qualidade da água, especialmente para sistemas alternativos de abastecimento
Concept of Planning Development of Coastal Resort Settlements under Conditions of Complex Relief
Authors: FINOGENOV Alexandr Ivanovich , POPOV Aleksey Vladimirovich
Published: May 2019

The scientific concept of planning development of small cities and settlements located on the coast of the Crimea peninsula of the Black Sea is outlined. The relevance of the study is due to the importance of the territory in question as the All-Russian Center for Mass Recreation, Tourism and Sport.

Subject: The principles of planning organization of modern urban development and objects of transport communications under conditions of complex relief on the territory of coastal settlements of Crimea (on the example of optimizing the urban planning structure of Gurzuf urban-type settlement).

Purposes: Development of scientific concept in the field of urban planning reorganization of the territory of small urban coastal settlements with the formation of new centers for the public, educational, hotel and transport-communal use. Improving the structure of urban development and objects of transport infrastructure.

Methods: The concept is based on a comprehensive analysis of the process of historical exploration and development of the coastal settlements’ territories of the Crimean Peninsula under the conditions of complex relief and ineffective development. The new methods of step-by-step reorganization of urban space are proposed.

Results: The concept determines further practical directions in the field of design, concerning the improvement of the planning structure of buildings within the boundaries of small urban settlements in Crimea, the creation of the spatially organized structure of new urban facilities for the public, hotel-tourism, educational and transport-communal use. The new methods of step-by-step reorganization of the structure of buildings and transport communications, ensuring the availability of facilities for mass resort recreation and tourism, sustainable public and transport links, preservation of the unique ecology of the Crimean resort zone are proposed.
Economic and Environmental Benefits of Using Waste Potential as a Valuable Secondary and Energy Resource
Authors: BEREZYUK Sergiy , TOKARCHUK Dina , PRYSHLIAK Natalia
Published: May 2019

The article is devoted to solving the problems of recycling in Ukraine, as the accumulation of waste every year becomes more and more threatening. Waste accumulated in landfills occupies 7 percent of the territory of Ukraine (more than 43 thousand km2), which simultaneously leads to pollution of water, soil, air and the deterioration of the ecological and economic situation in general. The experience of European countries in dealing with waste indicates the complexity and effectiveness of measures for their effective management, which is not currently available in Ukraine. The main objective of the article is to provide proposals on improving the processes of safe waste management in Ukraine, taking into account the EU experience and identifying a number of measures that will facilitate the effective management of solid household waste in Ukraine. The object of the research is municipal solid waste as a source of valuable secondary raw materials, as well as an energy resource. The research methodology includes the application of the dialectical approach and the methods of economic analysis: abstract-logical, statistical-economic, tabular and graphic, monographic, economic-mathematical (extrapolation method). The article highlights the ecological and energy efficiency of the secondary use of a valuable resource of solid household wastes. A scheme for organizing the effective utilization of solid household waste is proposed, the implementation of which is of practical importance in the implementation both at the level of individual communities and the state as a whole.
Investigating the Effect of Service Quality, Mental Image, Trust and Environment Brand on Emotional Satisfaction and Commitment
Authors: SHIRI Yousef Mirzaei , ALIPOOR Vahideh , AZIMI Hossein
Published: May 2019

The superior service quality enables an economic unit to distinguish itself from other competitors and compared with them, gain a series of competitive advantages. Increasing the service quality will increase customer satisfaction, followed by increasing positive word of mouth (WOM), reduced staff turnover and improved financial performance of the company. The aim of this study is to find the relationship between different elements of long-term cooperation between banks and customers. The research method is a survey-descriptive research and data collection tool is a standardized questionnaire that is localized and its reliability and validity have been reaffirmed. The statistical society of this study was all customers of Tejarat, Saderat, Eghtesade Novin banks in Zanjan and the questionnaires were distributed randomly among 400 customers of these banks. The conceptual model of the research processed using the structural equation model in PLS software. Findings showed that quality of services, mental image, trust and environment brand have a positive effect on customer satisfaction and emotional commitment. Also, customer satisfaction and emotional commitment have a positive effect on behavioral tendencies.
Spatio-Temporal Zoning of the Urban Lands’ Functioning for Ensuring the Sustainable Development of the City
Authors: ROGATNEV Yuri Mikhailovich , SCHERBA Valentina Nikolaevna , NAZAROVA Olga Sergeevna , FILIPPOVA Tatyana Anatolevna , DOLMATOVA Olga Nikolaevna
Published: May 2019

The problems of the modern land use development in the cities located in the oil and gas producing Siberian regions of Russia are reviewed in the article. The modern scientific ideas about the role of the modern land and property assets in small and medium-sized cities in adverse climatic living environment are explored for this purpose.

The study is aimed at improving the method for assessing the current organization of the land use in the municipal city of Nefteyugansk. The methodological provisions of land zoning with due consideration for its socioeconomic value and temporal changes are developed. The methodological provisions for a comprehensive assessment of the land use conditions aimed at using the spatio-temporal land zoning model are improved.

The results of the study can be used in the practice of local authorities and legal entities in urban planning, land and property relations, housing and utility services in territorial planning, development of land and property relations in the market conditions, improvement of the land payment system, determination of the land investment attractiveness, and creation of a unified basis for an objective land plot evaluation. The introduction of the results of the study into practice will allow to increase the efficiency of the land use, increase its value, and bring the socioeconomic indicators of the land and property assets of the city to a higher level.
Pro-Environmental Behavior of Consumers
Authors: PODVORICA Ganimete , UKAJ Fatos
Published: May 2019

This paper reports the results of a survey on pro-environmental behaviour of consumers within the urban zones of Kosovo. The objective of the study is to explore consumers’ affordability to purchase environmentally friendly products based on the gender roles and investigates the correlation of the consumers who consider that such purchases contribute to the environmental protection including local participation at environmental movements regarding efficient energy use and water efficiency. Findings reveal that despite low-involvement of consumers to environmental movements on efficient energy use and water efficiency initiated by environmental non-governmental organizations, there remains a lack of empirical research on national institutional environmental initiatives to promote and motivate pro-environmental behavior of consumers and create informed citizenry. This research presents the opportunity for further exploration of dimensions regarding product related pro-environmental consumers’ behavior and motivation factors.
Environmental Safety of Modern Kazakhstan: General Legal Analysis
Authors: KOSHKINBAEVA Aliya S. , ZHUMAGULOVA Sholpan R. , ZHANALIYEVA Aigul Z. , BIZHANOVA Aigul R. , KHAMZINA Sholpan S.
Published: May 2019

World experience shows that greening the entire socio-economic system of any state is the basis for successful solving of environmental problems and preventing environmental disasters. Environmental safety, as a component of national security, is an indispensable condition for sustainable development and is the basis for the preservation of natural systems and the maintenance of appropriate environmental quality. The Kazakhstan political and legal mechanism for ensuring environmental security against the background of multilateral and dynamically evolving international institutions has not achieved any significant efficiency yet. For many decades, Kazakhstan has developed a predominantly natural resource management system with extremely high technogenic pressure on the environment. Therefore, a fundamental improvement in the ecological situation has not occurred yet, and it is still characterized by the degradation of natural systems, which leads to a destabilization of the biosphere, a loss of its ability to maintain the quality of the environment, which is necessary for the community life. The article presents conclusions on the current list of threats to national security in the environmental field relevant for Kazakhstan. Specific offer has been made to improve the mechanisms for ensuring environmental safety, which includes: improving the efficiency of state control in the environmental protection and environmental management; optimization of licensing system of environmental management and environmental expertise; improvement of the environmental monitoring system; ecologization of legislation; systematization of legislation in the field of protection the environment; expansion of international cooperation.
Cultural Mapping - A Developmental Tool for Enhancing the Destination’s Image. Case Study of Cuttack
Authors: MOHANTY Shruti , MISHRA Sitikantha , MOHANTY Sasmita
Published: May 2019

Tourism is one of the major contributors of the global economy, which helps in generating millions of jobs and billions of dollars worldwide. In emerging countries it is considered as the only tool for development and by many communities it is the only chance for increasing the quality of life. If one looks from the socio-cultural perspective, tourism is the source that brings together people from different cultures and traditions with different background. Cultural mapping is a developmental tool that makes use of practical and participatory planning which is an emerging mode of research. Cultural mapping also makes use of the theory of “Making the Intangibles Visible”. Odisha has been the tourist’s paradise as it is a home to many historical and religious places. It is also culturally enriched in many ways, but the fact that it still lags behind cannot be hidden, when compared to other destinations in the world despite the richness in every aspect. Cuttack is a district in eastern Odisha which has a history of 1000 years, known as the Millennium City as well as the Silver City which can be the best example where Cultural Mapping can be used to enhance the image of the destination. The data collection method used in the study is questionnaire method with a sample of 100 respondents is taken by applying random sampling technique. The objective of the study is to find out the areas where Cuttack’s image as cultural city can be established through the innovative tool of cultural mapping. The result of this research showed that few factors are indicative that can be used in the cultural mapping thereby enhancing the destination’s image.
Diversity of Species and Benefits of Telajakan Plant as a Potential Tourism Attraction in Bali
Authors: DARMAD Anak Agung Ketut , WIRASITI Ni Nyoman , GINANTRA I Ketut
Published: May 2019

Telajakan is a place of reforestation, one of the elements of traditional green open space in Balinese homes. Plants planted in various species are diversified, in some categories of plant and have various benefits in Balinese society. The study was conducted in 2018 in the Cengkilung village, Denpasar Municipality and Penglipuran Village, Bangli Regency, Bali Province. Data collection methods are carried out through observation with inventory and identification of plants, interviews with owners of taxation. The plants planted in these two villages are mostly used for beauty or ornamental plants increase the family's economy, ceremonies or rituals, and protectors. The highest Important Value (IV) on trees category in Telajakan plants at the Cengkilung village are the cabbage tree (Cordyline australis) as much as namely 129%. The shrub and herbaceous categories are Crotons 'Wide leaf' (Codaium variegatum) and Japanese grass (Zoysia japonica) amounting respectively 75.3% and 43.4%. The Telajakan plants at Penglipuran Village, which are on the category of trees, shrubs and herbs with the highest important values are the Cananga tree (Cananga odorata), Dwarf umbrella tree (Schefflera grandiflora), and spider plant (Chloropithum comosum) 109%, 33.4% and 64.6%.
Cognitive Modeling in the Management of Economic Growth of the Agriculture in Russia
Authors: ANOKHINA Marina Y. , GOLUBEV Alexey V. , KONDRASHINA Olga N.
Published: May 2019

The article analyzes the processes of economic growth in the agriculture in Russia. The current state of the agriculture, characterized by a variety of technological structures and various levels of economic and social development of enterprises and rural areas, has been considered. Tendencies of development and the reasons restraining the further growth of industry have been shown. The parametric content of management system of economic growth of agriculture has been determined on the basis of cognitive modeling. A fuzzy cognitive map for management of economic growth of the industrial complex has been developed, the static and dynamic analysis of which allowed obtaining forecasts of the dynamics of agriculture under various management influences. As a result, a strategy for achievement of the target parameters of the economic dynamics of the agricultural economy has been formed. A conclusion on the prospects for the development of the agriculture with an effective agrarian policy is drawn.
Amplifying youth voice and cultivating leadership through participatory action research
Authors: Gardner Rachele , Snyder William M. , Zugay Ayda
Published: May 2019

This article presents the story of Youth Hub, a grassroots, neighborhood-based initiative in Boston, Massachusetts, highlighting its use of participatory action research (PAR) to amplify youth voice, cultivate leadership, and promote change. The article includes an explanation of the need from which Youth Hub emerged; a discussion of Youth Hub’s use of PAR, including benefits and challenges of the approach; a summary of key research findings; an examination of PAR’s usefulness for knowledge creation, including benefits and challenges; and an analysis of youth leadership and ownership in Youth Hub’s model, also including benefits and challenges. The article concludes with suggestions for how Youth Hub’s approach can be useful for amplifying youth voice and building youth leadership more broadly.
Community-engaged research through the lens of school closures: Opportunities, challenges, contributions, and lingering questions
Authors: Agard Claudette , Ansari Zakiyah , Conner Jerusha , Ferman Barbara , Pappas Liza N. , Shiller Jessica
Published: May 2019

This article expands upon and problematizes the practice of community-engaged research (CES) through the lens of school closings. Rather than employ a one-dimensional view of CES that portrays university researchers and community partners as collaborating equally on all stages of the research, we suggest a broader, more flexible understanding that incorporates various contextual factors. Drawing on local examples, from New York City and Baltimore, and one national effort to resist school closings, we  present three forms of CES: participatory action research (PAR), in which university researchers and community partners collaboratively engaged in almost all aspects of the process; the engaged learner, in which the researcher documented a community organizing campaign with the full support of the campaign organizers; and a grassroots listening project implemented without university partners. In each case, participants had to navigate the thorny issues of power differentials, race and racism, ownership and voice, and presentation and representation. Difficulties notwithstanding, CES has made important contributions to both the literature on and practice of school closings. We conclude the article with a discussion of some of the lingering tensions that characterize community-engaged scholarship.
Collaborative research for justice and multi-issue movement building: Challenging discriminatory policing, school closures, and youth unemployment
Authors: Glass Ronald David , Stoudt Brett G.
Published: May 2019

This special issue engages ethical, epistemic, political, and institutional issues in projects of collaborative research for justice that were designed with movements contesting policing, school closures, and youth disinvestment and unemployment. Three of the articles were collaboratively written by activists and scholars who drew from movements that deployed research for community-driven progressive change. The movements and the research are thus situated at the intersection of struggles against a resurgent anti-immigrant white supremacy, gentrification, a punitive carceral state, low pay and lack of meaningful employment opportunities, and the privatization of the public sector. These articles build upon and are in conversation with a set of related articles published in the spring 2018 special issue of Urban Education(Warren et al, 2018) that also addressed ethical, epistemic, political, and institutional tensions in collaborative research for justice. This EPAA special issue aims to advance the discussion through deep reflection within the context of focal ‘cases’ and within efforts to open space within universities for modes of engaged scholarship that can respond to the challenges of the current moment, as described in the articles that bookend the cases. Taken all together, this special issue demonstrates how scholars, educators, teachers, activists, community leaders, and policy makers can use the production and mobilization of knowledge as a force for building, supporting, sustaining, and advancing multi-issue movements for justice not just in schools and the academy but also in communities of color and others aggrieved by current inequities.
Towards a usage-based model of early code-switching: Evidence from three language pairs
Authors: Gaskins Dorota , Frick Maria , Palola Elina , Endesfelder Quick Antje
Published: May 2019

Usage-based studies trace children’s early language back to slot-and-frame patterns which dominate spontaneous language use. We apply the Traceback method to data from three bilingual children with English as one of their languages and Polish, German, or Finnish as the other to examine what these children’s code-switching has in common and how it differs in light of the genealogical distance between the languages used. Their bilingual constructions are derived from individual corpora of naturalistic interactions of each child respectively and traced back to monolingual language produced previously to establish whether they are unprocessed chunks or partially schematic units. Based on this, we propose a model of switching which helps us to distinguish between the qualitative aspects of bilingual use in these two types of combinations. Our results show that all three children filter out some mixing occurring in chunks before these give basis to longer units. Whatever bilingual combinations remain frozen in those units can be explained by phonological overlap of the children’s two languages, which is highest in the acquisition of English-German due to their genealogical proximity.
A State Estimation Method Based on Integration of Linear and Extended Kalman Filters
Authors: Farsi M. , Dehghan Manshadi M.
Published: May 2019

The Linear Kalman Filter (LKF) and Extended Kalman Filter (EKF) as correction-prediction observers are two common model-based filters, which are widely used to estimate the unmeasurable states and parameters in the chemical processes. The main disadvantages of LKF and EKF are low accuracy and reliability of estimation and high computational time, respectively. The main object of this work is the modification of conventional Kalman filter to cover the disadvantages of LKF and EKF. The proposed method is planned based on the systematic updating the Jacobian matrix of estimator applied on the nonlinear systems. In this regard, a linearity index is defined based on the characteristics of outputs to determine switching time between LKF and EKF to avoid unnecessary updating the Jacobian matrix. The performance of the proposed method is compared with the LKF and EKF considering four chemical benchmarks as the nonlinear state space models. Altought EKF and proposed filter present similar precision to estimate unmeasurable states, the proposed method has a lower computational time.
Synthesis of polycyclic phosphonates via an intramolecular Diels-Alder reaction of 2-benzoylbenzalaldehyde and alkenyl phosphites
Authors: Yamana Kenji , Nakano Hirofumi
Published: May 2019

In this paper, we present a Lewis-acid-promoted reaction of 2-benzoylbenzaldehyde and trialkenyl phosphites, which resulted in the formation of polycyclic phosphonates. The reaction proceeded via nucleophilic attack of trialkenyl phosphite on the carbonyl carbon of 2-benzoylbenzaldehyde. The subsequent intramolecular Diels-Alder reaction led to the formation of the cyclic phosphonate.