bluuebunny/crossref_metadata_2025 huggingface dataset:
A clustered regularly interspaced short palindromic repeats knockout method to reveal methyl-CpG binding domain 4 function
Authors: Ng Ayden
Published: November 2022

DNA methylation is an epigenetic mechanism tailored for DNA repression, engineered for regulating genetic expression without direct manipulation of the nucleotide sequence. One component of this process includes methyl-binding proteins (MBD), which have an affinity for methyl groups, and they competitively inhibit transcription factors from binding with genetic promoters. Interestingly, MBD4 is unique because, as opposed to transcriptional repression, it promotes gene repair & demethylation and is associated with various methylation-related diseases, such as Autism. By further studying MBD4, we can identify a potential therapeutic target for MRD and further understand the role of methylation on the epigenome in regards to seasonal plasticity. Therefore, this paper describes a CRISPR Knockout screen to isolate & repress MBD4 from its customary functionality with gRNA targets GGAAGGGGGUGCUUGUGAUG and GGAAGGGGGTGCTTGTGATGTGG in Astatotilapia burtoni Cichlid. I expect a morphological change in the Cichlid’s skin color (such change can be identified with computer vision COCO-Style-Dataset-Generator-GUI), which substantiates our belief that MBD4 does, in fact, play a significant role in seasonally-regulated epigenetic switches and can be targeted in methylation treatments. However, the exogenous factors relating to MBD4’s role in methylation remain to be investigated.
hp-Вариант метода коллокации и наименьших квадратов с интегральными коллокациями решения бигармонического уравнения
Authors: Шапеев Василий Павлович , Shapeev Vasiliy Pavlovich , Брындин Лука Сергеевич , Bryndin Luka Sergeevich , Беляев Василий Алексеевич , Belyaev Vasily Alexeyevich
Published: November 2022

Разработан новый алгоритм численного решения бигармонического уравнения. Он основан на впервые реализованном hp-варианте метода коллокации и наименьших квадратов (hp-МКНК) с интегральными коллокациями для эллиптического уравнения четвертого порядка в комбинации с современными способами ускорения итерационных процессов решения систем линейных алгебраических уравнений (СЛАУ). В hp-МКНК использовались его возможности измельчать шаги расчетной сетки (h-подход) и увеличивать степень базисных аппроксимирующих полиномов до произвольного порядка (p-подход). На примере численного моделирования изгиба шарнирно закрепленной изотропной пластины проведен анализ сходимости приближенных решений, полученных реализованным вариантом метода. Показано достижение высокой точности и повышенного порядка сходимости решений при применении полиномов высоких вплоть до десятой степеней в hp-МКНК.
Исследована эффективность комбинированного применения сочетающихся с МКНК алгоритмов ускорения итерационных процессов решения СЛАУ. Применены предобуславливание матриц СЛАУ; алгоритм ускорения итераций, основанный на подпространствах Крылова; операция продолжения на многосеточном комплексе; распараллеливание вычислительной программы с помощью OpenMP; модифицированный алгоритм решения локальных СЛАУ, определяющих решение задачи в каждой ячейке сетки. Последний, применимый в случае решения линейного дифференциального уравнения, позволяет более эффективно решать переопределенные СЛАУ в МКНК, реализуемом итерациями по подобластям, в которых вид матриц локальных СЛАУ не изменяется на каждой итерации. Комбинированное применение всех перечисленных способов ускорения уменьшило время расчетов на персональном компьютере более, чем в 350 раз по сравнению со случаем, когда использовалось только предобуславливание.
Математическое моделирование влияния спейсеров на массоперенос в электромембранных системах
Authors: Коваленко Анна Владимировна , Kovalenko Anna Vladimirovna , Узденова Аминат Магометовна , Uzdenova Aminat М. , Овсянникова Анна Вячеславовна , Ovsyannikova Anna Vyacheslavovna , Уртенов Махамед Али Хусеевич , Urtenov Mahamed Ali Huseevich , Бостанов Рамазан Алиевич , Bostanov Ramazan Alievich
Published: November 2022

В электромембранных системах перенос ионов вблизи ионообменных мембран вызывает концентрационную поляризацию, что существенно затрудняет массоперенос.
Чтобы нивелировать эффект концентрационной поляризации и увеличить массоперенос, используют спейсеры.
С гидродинамической точки зрения спейсеры уменьшают толщину пограничного слоя за счет увеличения перемешивания в глубине раствора и создания нормальной составляющей конвективного переноса, ионы могут достигать мембран быстрее и ток увеличивается. Однако спейсеры значительно увеличивают гидродинамическое сопротивление, и, соответственно, расходы на прокачку раствора.
Впервые определены основные закономерности переноса ионов соли в канале обессоливания электродиализного аппарата со спейсерами разных форм и расположений с учетом электроконвекции в сверхпредельных токовых режимах.
А именно, показано с использованием вольт-амперной характеристики, что на различных стадиях процесса обессоливания оптимальными являются спейсеры разной формы и местоположения.
Представлены результаты математического и имитационного моделирования процесса переноса ионов соли в электромембранных системах со спейсерами в сверхпредельных токовых режимах.
Прямое численное 2D-моделирование проводилось для связанной системы уравнений Нернста-Планка-Пуассона и Навье-Стокса без подгоночных параметров. Использовался метод конечных элементов в сочетании с методом последовательных приближений и сегрегации при решении краевых задач систем нелинейных дифференциальных уравнений с частными производными.
Новизна метода заключается в том, что после дискретизации по времени задача на каждом временном слое расщепляется на гидродинамическую и электрохимическую, каждая из которых решается методом последовательных приближений до полного взаимосогласования.
Вероятностные модели для анализа обратных экстремальных задач комбинаторики
Authors: Энатская Наталия Юрьевна , Enatskaya Nataliya Yur'evna
Published: November 2022

В обратной экстремальной задаче для комбинаторной схемы при заданном значении целевой функции вида определенного экстремального значения ее характеристики строится вероятностная модель, обеспечивающая получения этого значения в ее исходах. Рассматривается два типа таких характеристик, относящихся к каждому или совокупности исходов схемы.
Доасимптотический анализ такой модели проводится авторским перечислительным методом. Его основу составляет построение итерационного случайного процесса с итерациями последовательных этапов нумерованного бесповторного перечисления и формирования исходов схемы. Итерационное развитие процесса представляется вероятностным графом.
Исследование исходов схемы по модели в перечислительном методе проводится по следующим направлениям: визуального нумерованного представления исходов схемы, нахождения их числа, установления взаимно-однозначного соответствия между видами и номерами исходов схемы, получения их (управляемого случайным процессом перечисления исходов схемы) вероятностного распределения и их моделирования с этим распределением.
Наряду с непосредственным исследованием схем по указанным направлениям предлагаются алгоритмы получения результатов для них путем их частичного пересчета из результатов аналогичного анализа более общих, ранее изученных схем с меньшими ограничениями на значения рассматриваемых характеристик.
Evaluation and Assessment of Existing Design Codes and Standards for Building Construction
Authors: Abdulqader Diman N. , Atrushi Dawood S.
Published: November 2022

Building design codes (BDC) are used to control the construction industry in general and building design in particular. The BDC offers the construction sector with a standard language and set of requirements. There are several BDCs developed and utilized for construction purposes throughout the world. Certain design codes are employed in structural design to assure the structure’s health and safety, as well as its cost-effectiveness. It also assures that the structure is sufficiently sturdy to endure all potential climatic conditions, bear its intended load, and is integrated to ensure effective use of building materials and resources. This research aims to compare various building construction design codes to identify and explore the most appropriate standard in terms of safe design, economics, and availability of details. In Kurdistan and different parts of Iraq, many international companies have designed building structures with various codes during the past 20 years. This is a bad condition since the government has no control over the construction of the buildings, which includes both the code and the building materials. There is currently no overview of the design codes in use in Kurdistan, nor is it clear whether they are congruent with what students’ study in institutions.
Implementasi Nilai-Nilai Pancasila di Sektor Perbankan
Authors: Pradipta Bagas Darma , Pertiwi Indah , Antari Berti Wahyu , Fitriono Riska Andi
Published: November 2022

In implementing the Basic Laws on Banking and the Basic Laws on Bank Indonesia, Pancasila values are needed in the banking sector in order to realize social justice in the form of equity. This study aims to make the Basic Banking Laws and Bank Indonesia Basic Laws applicable to the Indonesian banking industry so that they can reflect the values embodied in Pancasila and realize social justice in the banking sector.
Penilaian Tingkat Eco-driving pada Trans Sarbagita Koridor II untuk Mendukung Konsep Transportasi Berkelanjutan di Provinsi Bali
Authors: Apsari Putu Aprilia , Basuki Yudi
Published: November 2022

Nowadays, more people choose to live in urban areas for economic, technological, sociological or political reasons. This is the cause of increasing population and population density in urban areas. The drastic increase in population can cause various problems. One of the most important problems that can be caused is traffic congestion and the increase in the resulting CO2 emissions. Urban communities have very dynamic mobility and in their mobility they prefer to use private vehicles rather than existing public transportationAlthough there has been Trans Sarbagita as a government effort to provide sustainable public transportation, not many people have taken advantage of the existence of Trans Sarbagita. As a result, Trans Sarbagita's total income is not proportional to its operational costs. In order to reduce operational costs, there are several ways that can be done, one of which is eco-driving. Eco-driving has been widely introduced as an environmentally friendly and economical way of driving that supports aspects of sustainable transportation, but not everyone practices or even knows this, including Trans Sarbagita drivers. Therefore, there is a need for an assessment of the level of eco-driving, especially on Trans Sarbagita to support the concept of sustainable transportation.The data used is a score based on the Guttman scale from the results of observations of five eco-driving indicators for 24 drivers on Trans Sarbagita Corridor II. Based on the analysis that has been carried out, the trans Sarbagita Corridor II eco-driving level is generally included in the medium category. The category level of the bus stop segment is divided into 2 categories, namely 8 bus stop segments with a high eco-driving category and 18 bus stop segments with a moderate eco-driving level. Based on the three aspects of sustainable transportation that must be met, Trans Sarbagita Corridor II is only able to meet all the criteria in the social aspect. In the economic aspect, Trans Sarbagita Corridor II is only able to meet the area accessibility criteria of the 3 existing criteria. Meanwhile, on the environmental aspect, Trans Sarbagita failed to meet the only criterion that must be met, namely the minimization of environmental pollution due to the impact of transportation. Based on the description above, from the three existing aspects, Trans Sarbagita Corridor II has not been supported by economic and environmental aspects, so it can be concluded that Trans Sarbagita Corridor II has not fully supported the concept of sustainable transportation.
Kelembagaan Masyarakat Sebagai Media Partisipasi Masyarakat Berbasis Komunitas Cerdas dalam Pengelolaan Hutan Mangrove di Kelurahan Mangunharjo
Authors: Aafiyah Nabilah , Mussadun Mussadun
Published: November 2022

Mangrove forest management is inseparable from the role of the local community as well as the role of policy makers and other parties who have contributed to creating sustainable mangrove forests. The existence of community institutions can be able to restore and develop the potential of mangrove forests to be a source of flood and tidal control to increase the living standards of coastal communities. In line with the development of the Smart City Semarang Masterplan, the mangrove management community institution makes it possible to tackle the problem of increasing the extent of flood and tidal inundation in the city of Semarang by optimizing the preservation of mangrove forests based on the dimensions of a smart society as it contains a smart community program. Therefore in this article used the method of participation analysis, rank spearman analysis and institutional analysis is used to determine the suitability of the role of community institutions as a media for community-based smart community participation in mangrove forest management. The results of the analysis conducted is through participation analysis obtained participation value of 52.87 where the respondents have a broad understanding of the implementation of mangrove forest management activities and have a sense of responsibility and are actively involved in mangrove forest management in Mangunharjo Village. Supported by the results of the spearman rank correlation analysis showed a strong correlation with mangrove management participation in Mangunharjo Village, specifically the experience of participating in mangrove management programs with a correlation coefficient value of 0.641. And the results of the institutional analysis have an average score of 59.41 which indicates that there are community institutions that have played a role as a media for community-based smart community participation in mangrove forest management in Mangunharjo Village according to the smart community indicator.
Tingkat Pelayanan Ruang Terbuka Hijau Publik Berdasarkan Kebutuhan Masyarakat di Perumnas Pucang Gading Demak
Authors: Azzam Rafi Faishal , Susanti Retno
Published: November 2022

Green open space in residential areas is one of the facilities that must be provided as a space for community activities and has an ecological function for the environment. Perumnas Pucang Gading is a settlement that has existed since the 1990s and there is green open space in each hamlet as a space for residents' activities. However, in its utilization, green open space is not widely used and instead is used for personal interests, one of which is for parking lots. This study aims to evaluate the level of green open space services at Perumnas Pucang Gading based on the needs of the community. The research approach was carried out in a quantitative descriptive manner using spatial analysis techniques, scoring, and frequency distribution. The results of the study show that in terms of quantity, the availability of green space services has been 75% fulfilled, namely based on the distribution, range, and area needed. Then in terms of quality, green open space obtained a sufficient/average score from the functional, technical, and behavioral aspects with a score of 3.1 out of 5.0. However, it turns out that the availability of green open space is not in accordance with the criteria needed by the community, namely a sports field with social space and is fulfilled by vegetation elements which are not in accordance with the current existing conditions.
Cyclic performance of moment connections with reduced beam sections using different cut-flange profiles
Authors: Al-Kannoon Muslim Abdul-Ameer , Al-Thabhawee Hayder Wafi
Published: November 2022

Reduced beam section (RBS) behaviours with various cut-flange configurations were investigated numerically in this study. A three-dimensional finite element model material non-linearity was built and validated experimentally, and the impacts of the cut--flange profile on the moment-rotation behaviour and ductility response of moment-resisting connections were investigated in a parametric form. Five-moment connections with various forms of decreasing beam flange were thus modelled using ABAQUS software and compared in terms of cyclic behaviour. RBS with circular, rectangular, trapezoidal, triangular, and drilled holes cut-flange configurations were adopted, and the finite element analysis results showed that radius cut RBS have uniform stress contours, while a re-entrant corner in rectangular, trapezoidal, or triangular cut-flange profiles’ connections may result in stress concentration, resulting in a fracture of the flange. In addition, the numerical testing showed that the RBS connection with a circular cut-flange profile offers a lower rupture index than other connections. Thus, the RBS created using circular cut-flange profiles dissipates more energy than other connections.
Using modified inverse distance weight and principal component analysis for spatial interpolation of foundation settlement based on geodetic observations
Authors: Beshr Ashraf A. A. , Kaloop Mosbeh R.
Published: November 2022

The article presents a novel computation technique for predicting the settlement of reinforcement concrete (R.C) raft foundations based on total station and precise leveling measurements. Modified inverse distance weight (MIDW) and principal component analysis (PCA) are developed to predict the nonmeasurable settlement of raft foundations and are compared to regression techniques. Wall measurements are used to verify the proposed interpolation methods. Six observation epochs were carried out over 3 years for the R.C raft foundation of a multistory building in Baltim, Egypt, which rests on clay soil, to monitor and predict the foundation settlement. The obtained results show that PCA and MIDW models outperform other models in interpolating nonmeasurable (invisible) points, while the accuracy of MIDW is the best. The developed techniques can be used to interpolate nonmeasurable (invisible) points to understand the actual behavior of foundation settlement. The monitoring building showed that the slope of the foundation in the X direction is 7.9 and 14.5% after 5 and 26 months, respectively.
Taxonomic reassessment of the chaco mice of the genus Andalgalomys Williams and Mares, 1978 (Rodentia, cricetidae) with a redefinition of Andalgalomys olrogi Williams and Mares, 1978
Authors: Quatrocchi Maira , Ojeda Agustina A. , Teta Pablo
Published: November 2022

The genus Andalgalomys Williams and Mares, 1978 includes three species of small phyllotine rodents: Andalgalomys olrogi Williams and Mares, 1978; Andalgalomys pearsoni (Myers, 1977); and Andalgalomys roigi Mares and Braun, 1996. These mice are distributed from southeastern Bolivia and western Paraguay to west-central Argentina, occupying mostly semi-desert environments, such as the Dry Chaco and High Monte. Available phylogenetic analysis of DNA sequences suggests that Andalgalomys olrogi and Andalgalomys roigi, which also share the same diploid complement, constitute the same species. We tested this hypothesis through a qualitative and quantitative morphological approach, in order to integrate different lines of evidence. Based on the largest sample analyzed to date, we found that some of the supposedly diagnostic traits of both Andalgalomys olrogi and Andalgalomys roigi (e.g., dorsal coloration) are more variable than previously documented. In addition, principal component analysis failed to separate Andalgalomys olrogi from Andalgalomys roigi in the multivariate space, although clearly segregate Andalgalomys pearsoni from these two taxa. Based on these findings, plus previous evidence, we consider Andalgalomys roigi as a junior synonym of Andalgalomys olrogi.
Porcupines in Italian islands: update on the distribution of Hystrix cristata in Sardinia
Authors: Milana Giuliano , Viviano Andrea , Mori Emiliano
Published: November 2022

In the last few decades, the crested porcupine (Hystrix cristata L., 1758) showed a remarkable range expansion in Italy, due to legal protection, climatic change and antropochorous releases. Particularly, porcupines have been released also in Sardinia, with first records of this large rodent in the wild dating back to 2005. Historical and social factors related to the progressive urbanization and the consequent abandonment of the traditional land use in mountain landscapes probably helped the re-expansion of forest, uncultivated fields and of animal’s species associated with these habitats. In Sardinia, a population establishment and a subsequent expansion of the area of distribution can be predicted as large portions of the island are highly suitable for the crested porcupine. Therefore, this recently introduced population should be removed to limit potential ecological and social conflicts.
Secret information security system in computer network based on Bayesian classification and nonlinear algorithm
Authors: Wu Hao
Published: November 2022

To solve the problem that most computer network security assessment systems cannot comprehensively analyze data, this article proposes a research method for computer network confidentiality information security system based on the Bayesian classification algorithm. This research takes the computer network security secret-related information security as the core, cleverly uses the EBCA back-propagation model, and comprehensively uses nonlinear functions to propose a computer network secret-related information security application system considering EBCA, which effectively solves the complex cross-linking relationship. The effectiveness of the method is verified by simulation experiments. Simulation experiments show that when the network performance is in the optimal state, the slope is 1, the intercept is 0, and the fitting degree is 1. The method proposed in this article is especially suitable for the nonlinear characteristics of computer network security and can accurately, comprehensively, and systematically reflect the security operation status of network security and confidential information. Then, through the simulation test, it is found that the method in this study can effectively meet the error requirements of equipment integrity and equipment normal rate.
Frequency of Multiple Modals with Might on the Web
Authors: Cehan Nadina
Published: November 2022

The paper investigates multiple modals such as might could, might would, might can and would might. These are just a few of the core modal combinations with might which are being looked at through the use of iWeb and GloWbE, two corpora of online texts. The research primarily reveals the multiple modals’ frequency in the corpora. It also shows that they are found in both American and British English. In addition, their negation and inversion patterns are displayed.
Person and Empathetic Deixis in the Institutional Discourse
Authors: Niţă Oana-Maria Puiu
Published: November 2022

The paper explores the use of person and empathetic deixis in the institutional discourse within an interdisciplinary landscape. It underpins a corpus-based approach, focusing on texts on COVID19 pertaining to the World Health Organization. Our aim is to demonstrate that deictic pronominals have collective self-reference, expressing solidarity and empathy.
Dorothea Tanning’s Reimagining of the Maternal
Authors: Glăvan Gabriela
Published: November 2022

Dorothea Tanning’s longstanding interest in the maternal element completes the artist’s complex relationship to femininity and the female experience, turning them into essential themes in her oeuvre. I shall explore the particular manner in which the American Surrealist integrates and transforms the notion of motherhood in her art. I shall also argue that Tanning’s works as a writer offer an original insight into this cardinal theme in western art, as she dismantles common tropes and refashions them into a new, unusual language.
The Binomials and Multinomials in two English Translations of the Lotus Sutra (Chapter Two)
Authors: Zhao Qian
Published: November 2022

The Lotus Sutra, an important Buddhist classic, is strongly rhetorical with its frequently used binomials (word pairs). This paper studies its two most recent English translations by Watson (1993) and Reeves (2008), the second chapter in particular, and conducts comparative research into the formal, etymological, semantic, sequential and other distinct properties of the binomials and multinomials employed by different translators.
Americana bei Jean Bodin und Johann Fischart, Hexen bei Jean de Léry
Authors: Perplies Helge
Published: November 2022

The scope of Early Modern Demonology is universal, for the perceived threat of the devil is omnipresent, stretching through time and space. This article examines various utilizations of the description of central and south American indigenous peoples in demonological discourse. By means of three closely related examples, I will demonstrate the discursive conflation of deviant behavior in Europe and in America through comparisons and transferences: Jean Bodin’s Démonomanie des Sorciers (1580), its German translation by Johann Fischart (1581/1586), and Jean de Léry’s writings, especially his Histoire d’un voyage (1578/1585). Within this discursive nexus, Léry compares the American Indigenes to European Catholics, whereas Bodin compares them to European witches - and Fischart completes this argumentative triangle by calling for European Catholics to be held accountable for comparable acts in the same way as European witches.
Gustav Freytags lateinische Qualifikationsschriften De initiis scenicae poesis apud Germanos (1838) und De Hrosuitha poetria (1839)
Authors: Walser-Bürgler Isabella
Published: November 2022

The article investigates Gustav Freytag’s dissertation De initiis scenicae poesis apud Germanos [On the beginnings of dramatic poetry in Germany] and his habilitation De Hrosuitha poetria [On the poetess Hrotsvitha], written and published in 1838 and 1839, respectively. Usually disregarded in analyses of Freytag’s oeuvre as insignificant minor texts or pointless Latin writings among his otherwise exclusively German historiographical and literary production, they serve, in a nutshell, as early comprehensive samples of his life-long approach to cultural historiography and German literature. More precisely, one could term them the ›groundwork‹ constitutive for many of his later efforts as a historian and author. Apart from dissecting Freytag’s qualification papers in this respect for the first time, the article also expands on the institutional framework of early nineteenth-century university education in Germany and its upheld practice of Latin scientific discourse.
Philanthropische Inklusionen: Gemeinnützige Stiftungen in der Gesellschaft
Authors: Moser Evelyn
Published: November 2022

Private, gemeinnützige Stiftungen sind nicht nur in allen Bereichen der modernen Gesellschaft präsent, sondern auch ein sichtbarer Gegenstand öffentlicher Debatten und umfangreicher sozialwissenschaftlicher Forschung. Gesellschaftstheoretische Zugriffe, die der facettenreichen Einbettung von Stiftungen in ihre sozialen Kontexte gerecht werden, fehlen bislang. Dieser Beitrag setzt an diesem Desiderat an und lotet das Potenzial einer inklusionstheoretischen Perspektive aus. In einer dreiteiligen, explorativen Skizze untersucht er, wie sich Stiftungen in unterschiedliche gesellschaftliche Inklusionsverhältnisse einfügen, welche Effekte ihre Tätigkeiten auf die Adressierbarkeit von Personen im Stiftungsumfeld haben und welche sozialen Rollen im Kontext von Stiftungen entstehen. Der erste Skizzenteil widmet sich den Ursprüngen moderner Stiftungen in der stratifizierten Gesellschaft des christlichen Mittelalters. Der zweite Teil rekonstruiert das spezielle Verhältnis von Stiftungen und Politik, das sich mit der Ausrichtung auf das Gemeinwohl in der frühen Neuzeit andeutete und bis in die Gegenwart prägend ist. Der dritte Teil blickt auf die Einbettung von Stiftungen in die Inklusionsverhältnisse gesellschaftlicher Funktionssysteme jenseits der Politik.
Dokumentieren als kommunikative Form im Medium der Darstellung
Authors: Bohn Cornelia
Published: November 2022

Der Beitrag schlägt eine Erweiterung der Medien- und Kommunikationstheorie Luhmanns um einen Medientyp vor, den ich als Darstellungsmedien bezeichne. Der Text kombiniert einen Theorievorschlag mit historisch semantischen Rekonstruktionen. Dazu werden die Konzepte Medium und Form, Prämissen ereignisbasierter Sozialtheorien sowie Konzepte und historische Semantiken des Darstellens aufeinander bezogen. Ausgangspunkt und Exemplum des Artikels bildet das konkrete Phänomen des Dokumentierens als kommunikativer Form im Horizont der gegenwärtig in der Digitalisierung angekommenen unabschließbaren Morphogenese von Kommunikationsmedien und -formen. Um die soziologische Reichweite des Phänomens zu verdeutlichen, werden Semantiken des Dokumentierens vorgestellt, die sich in höchst unterschiedlichen gesellschaftlichen Feldern wie Organisationen und Administrationen, moderne Wissenschaft, Publikationswesen und Wissensvermittlung, Personenidentifikation und der modernen Kunst herausgebildet haben.
Direct-acting antiviral therapy may help restore HCV-induced impaired redox balance and liver fibrosis process
Authors: Bal Tayibe , Doğan Serdar , Özcan Oğuzhan , Çabalak Mehmet , Çirkin Berfin
Published: November 2022

Objectives

The aim of this study was to investigate the changes in thiol/disulfide balance, pro-fibrotic mediators (transforming growth factor-beta [TGF-β] and periostin) and a potential biomarker for the prediction of HCV-induced HCC (3β-hydroxysterol Δ24-reductase [DHCR24]) during direct-acting antiviral (DAA) therapy in chronic hepatitis C (CHC) patients.

Methods

This prospective cohort study included 56 non-cirrhotic, treatment-naive CHC patients who were treated with DAAs between January and June 2020. Laboratory tests, including serum total/native thiol, TGF-β

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periostin, DHCR24, total bilirubin and albumin levels were measured and disulfide levels were calculated at baseline, then at 1 month and at the end of therapy (EOT).

Results

Of the 56 patients, all achieved a sustained virological response after DAA therapy. There was a significant decrease in serum levels of disulfide and TGF-β, (p=0.020 and p<0.001, respectively) and a significant increase in serum levels of native thiol compared with baseline levels (p=0.010). There was no significant change in levels of total thiol, DHCR24 and periostin levels. Serum TGF-β levels were found to be positively correlated with total bilirubin levels (rs=0.470, p=0.001) and negatively with albumin levels (rs=−0.483, p<0.001). A significant moderate positive correlation was determined between baseline serum DHRC24 and disulfide levels (rs=0.356, p=0.007).

Conclusions

The study results suggest that the DAA therapy may help to restore the impaired thiol/disulfide balance and reduce the pro-fibrotic process in CHC patients by markedly decreasing serum levels of TGF-β, a key player in HCV-induced liver fibrosis.
Cherry River: Art, Music, and Indigenous Stakeholders of Water Advocacy in Montana
Authors: Davidson Jane Chin
Published: November 2022

The 2018 performance event, Cherry River, Where the Rivers Mix, designed by Indigenous scholar, Dr. Shane Doyle, a member of the Apsaalooke Crow community, in collaboration with artist Mary Ellen Strom, a founder of the nonprofit Mountain Time Arts program, endeavored to address the surging environmental problems associated with water in Montana. Drought and water scarcity impacts a diverse population, including Indigenous communities and the life of nonhuman plant and animals beyond the urban and rural populace of landowners, ranchers, and farmers. In 2021, the U.S. Department of Agriculture declared a federal emergency of drought disaster in a majority of Montana’s counties, and the recent disappearance of glaciers at Glacier National Park is of great concern. Doyle and Strom sought the opportunity to foster relationships and greater dialogue among regional constituencies, particularly among Indigenous and non-Indigenous communities, and they were successful in raising awareness regarding the need for equitable water use and conservation. Cherry River brought an audience of local people to the banks of the Missouri River Headwaters, where the Gallatin, the Jefferson, and the Madison rivers converge to present a mix of American music—Crow and Northern Cree singing, Métis violin, Big Band Jazz. The sound of the music of the rivers, however, was the all-encompassing engagement for those who attended. Drought and environmental crisis impels us to think more broadly about the role of the arts and humanities in environmental studies. Can the arts and performance contribute a different model for environmental advocacy, acknowledge a different perspective for understanding ecologies, and therefore expand the transdisciplinary process for engaging in environmental studies?
Speech style used in Jimmy Kimmel Live talk show
Authors: Ilenia Oktavia Fransiska , Yustisiana Arielia
Published: November 2022

This research aimed to analyze the use of speech style and the factors that influenced the use of speech style in the Jimmy Kimmel Live Talk Show in all episodes that were aired in November 2021. Speech style is the choice of words based on the level of formality used by a person in communicating, which is influenced by several factors. In this research, the researcher applied Joos' (1976) theory of speech style and Holmes' (2013) theory of factors that influenced the choice of speech style. This research was classified as qualitative descriptive. All of the data in this research were taken from the conversation subtitles between the host and the guest/s, which contained various types of speech styles and were transcribed into the text form. Then, the collected data were classified based on the types of speech styles. After that, the factors that influenced the host and the guest/s to use the speech style were analysed. Based on the results of the research, there are four of the five types of speech styles in this research. Frozen speech style was not found in this research. The four speech styles found in this research were formal (6%), consultative (12%), casual (81%), and intimate (1%), the dominant type of speech style is casual speech style and the least one is intimate speech style.
The issues of diaspora and displacement in Elif Shafak's The Island of Missing Trees
Authors: Sabbah Sherien , Ayuningtyas Paramita
Published: November 2022

This paper aims to analyse the issues of diaspora and displacement in Elif Shafak’s The Island of Missing Trees. The novel focuses on the Kazantzakis family that is forced to flee their homeland Cyprus to England. A unique aspect of the novel is that half of it is narrated by a fig tree. Therefore, this novel will be analysed both from Multicultural and Ecocritical perspectives. To analyse the data, this research uses a qualitative descriptive method, particularly textual analysis. In the end, the result of this paper shows a connection between the issues of diaspora and displacement with natural environment. This analysis is important because in the 21st century conflicts are still happening, which force people to leave their homeland and significantly affect the natural environment.
Óptica para optómetras apuntes de clase
Authors: Barrios Arlante Juan José
Published: November 2022

This writing is directed, initially, to optometry students, for optometrists and ophthalmologists who like to reinforce their learning in this field as beautiful as the study of the eye. It is hoped that by reading this document, the apprentices, who traced their horizon to train in optometry as their life project, will be able to acquire a series of knowledge that will be reinforced throughout their studies and in their work as optometrists. A language was used that links the reader to the explanations of the phenomena in the field of physics and, particularly, optics. This implied that the physical-mathematical procedures were shown step by step to facilitate the understanding of each of the equations acquired or represented in the document, without extrapolating to the athematical formalism related to electromagnetic theory. In addition, this is the first writing that I do taking into account the classes developed with a large number of optometry students, through whom I was able to see some difficulties that usually arise when reading physics texts. The talks with fellow optometrists in each semester strengthened knowledge in this beautiful field, leading the author to carry out research projects and direction of degree projects where optics is positioned as a fundamental tool for these eye lovers. Esta investigación educativa, en el marco de la economía del conocimiento, parte de la identificación en el contexto mundial de bajos índices de generación de nuevo conoci¬miento y competitividad en el país y en la región. Colombia se ubica en un puesto no muy destacado según el Índice de Competitividad Global, y Bucaramanga, ciudad capital de región, tan solo obtiene algo más de 5 puntos sobre 10 a nivel nacional. Es importante señalar los avances y esfuerzos que en esta materia se vienen realizando, los cuales siguen apareciendo insuficientes en el panorama mundial, principalmente al señalar la importancia de una mayor articulación e integración de distintos sectores para la consecución de mejores resultados. Esto llevó a indagar por las dinámicas de las redes de conocimiento y los principales actores de la región relacio¬nados con la generación de conocimiento y competitividad, encontrando que en el área metropolitana de Bucaramanga hay una gran dispersión de esfuerzos, reducidos niveles de confianza, hace falta una apuesta clara para la innovación, no se cuenta con una definición apropiada de acciones de parte de las universidades, de las empresas y del Estado, ni de sus roles, hay fuga de conocimiento, pérdida de interés en la participación regional, muy pocas relaciones, falta de sostenibilidad de los proyectos, bajos niveles de gestión del conocimiento y del aprendizaje, entre otros.
The influence of rosin, blowing agent, and mould type on the sound insulation of paper-based foams
Authors: Li Haoyuan , Luo Lin , Qiao Jiantong , Li Xinyu , Tu Jiahe , Wang Qingchun , Chen Zhongjia
Published: November 2022

Wooden foams have been extensively researched in recent years because of their special structure and green features. At the same time, noise pollution is increasing, prompting sound insulation to become another research focus. In this study, a three-factor, five-level orthogonal experiment was designed, and 25 sets of specimens were produced for testing and analysis in 19 frequency bands. To measure the sound insulation, two criteria were used: the material sound loss rate (for determining mass) and the material sound loss rate (for determining volume sound). After measuring, these two values were compared. It was found that the material was highly isolated from high frequency noise. The amount of adhesive used and the choice of mould had a considerable effect on the sound insulation of the specimens as the foaming rate was varied. Good sound insulation can be achieved when the foaming rate is very low and when the foaming rate is very high.
Effect of thermal bridge in light-frame wood wall
Authors: Zhang Siyi , Huang Zilan , Wu Yue , Zhu Yixin
Published: November 2022

The presence of thermal bridges in a wall increases local heat conduction of the building envelope, resulting in a decrease in the wall’s average thermal resistance. Simultaneously, the internal surface temperature of thermal bridge is lower than that of the surrounding areas and shows a tendency of condensation. Therefore, it is necessary to employ thermal bridges in the stage of construction design. In the research, a two-dimensional steady-state numerical simulation was performed targeting thermal bridges with light-frame wood wall. Meanwhile, the heat bridge effect was simulated under different circumstances by changing the types of insulation and cladding materials, the number of the studs, and the framing factor. The results showed that the linear heat transfer coefficient increased linearly as the studs and framing factor rose. After the test was validated, the relative error rate between the simulated correction coefficients and the experimentally derived correction coefficients was 11.4%, indicating that the correction coefficients can be simulated.
Experimental study on heat transfer of alfalfa during the vibration-assisted compression
Authors: Wang Haoyi , Wu Pei , Du Haijun , Li Ruoyan , Ma Yanhua
Published: November 2022

Compression alfalfa into briquettes is an effective way to solve the problem of storage and transportation. In the process of compression, heat is generated, which raises the temperature in the material. The appropriate temperature can improve the quality of alfalfa briquettes. In this paper, the effect of assisted vibration frequency, moisture content, and particle size on the compression temperature were tested. The results showed that when the vibration was applied, the material particle temperature in the mold rose significantly, and the core particle temperature rose faster than the edge temperature. The vibration frequency was the most significant factor affecting heat transfer in the three studied factors. When the moisture content and particle size were constant, the heat transfer effect increased first and then decreased with the vibration frequency, and it had an optimal value at 17 Hz. When the vibration frequency and particle size were constant, the heat transfer effect increased first and then decreased with the moisture content. It had an optimal value of 20%. The experimental results explained the effect of vibration frequency, moisture content, and particle size on temperature variation during alfalfa compression and provided a basis for reasonable process parameters.
Wet-spinning of TEMPO-oxidized lignocellulose nanofibrils and functionalization of the filament with Ag nanoparticles
Authors: Park Chan-Woo , Bandi Rajkumar , Dadigala Ramakrishna , Han Song-Yi , Kim Jeong-Ki , Kwon Gu-Joong , Kim Nam-Hun , Lee Seung-Hwan
Published: November 2022

Wet spinning was studied for lignocellulose nanofibrils (TOLCNF) obtained by TEMPO oxidation and mechanical defibrillation of deep eutectic-like solvent-treated lignocellulose. First, the morphological characteristics, water retention value, and specific surface area of the TOLCNF were studied. The effects of the TOLCNF concentration (1.5, 2.0, and 2.5 wt%) and spinning rate (0.1, 1.0, and 10 mL/min) on the wet-spun filament diameter, orientation index, and tensile properties were studied. With an increase in the TOLCNF concentration, the average diameter increased, whereas the orientation index and tensile strength decreased. An increased spinning rate resulted in an increased orientation index and tensile strength but a decrease in the average diameter. To further extend their applicability, Ag nanoparticles (AgNPs) were grown in situ on the filament surface using UV irradiation. Spherical AgNPs with diameters of 30 to 90 nm were observed using scanning electron microscopy. An increased AgNP content improved the tensile strength and elastic modulus of the filaments.
Degree of polymerization of fibers from Wikstroemia bark vs. the durability of Kaihua paper
Authors: Chen Hua , Jiang Liuhao , Huang Hongjian , Wang Jianhua , Song Junsheng , Wo Qizhong , Liu Mingfang , Yang Ting , Wang Yiying , He Yingying , Luo Ruyi
Published: November 2022

In order to determine the influence of bast fibers isolated from Wikstroemia bark on the durability of paper, self-made paper was prepared using bagasse pulp mixed with Wikstroemia bark pulp using Kaihua paper manufacturing technology. The durability properties of the paper obtained with different proportions of Wikstroemia bark pulp were measured and analyzed. The results showed that Wikstroemia bark can lower the acidity, improve the mechanical strength, and delay the aging of paper. The mechanical strength showed an exponential relationship with the amount of Wikstroemia bark pulp added to the paper pulp. There was a linear positive correlation between the initial polymerization degree of the paper and the amount of Wikstroemia bark pulp, while the molecular fracture rate of the paper with Wikstroemia bark pulp was considerably reduced. Wikstroemia bark fibers are long fibers with high strength. At the same time, Wikstroemia bark fibers differ greatly in length, so the uniformity can meet the requirements. The durability of the paper made from only bagasse pulp was poor, but the overall strength and polymerization degree of the paper improve after being mixed with Wikstroemia bark pulp.
Elucidation of lignin and polysaccharide linkages in wheat straw by 2H/13C isotopic tracer
Authors: Xie Yimin , Chen Xudong , Zhang Kai , Cui Sheng , Zhang Gongxia
Published: November 2022

To elucidate chemical linkages between lignin and polysaccharides, the aqueous mixed solutions of coniferin-[α-13C], syringin-[α-13C], D-glucose-[6-2H], and phenylalanine ammonia-lyase inhibitor were injected into a living wheat stalk. Internode tissues with high abundance of 2H-13C were collected. The milled wood lignin, lignin-carbohydrate complex (LCC), and residual LCC (R-LCC) with enrichment of 2H-13C were isolated. The 13C and 2H abundances showed that the lignin and polysaccharides of internode tissues were labeled by 13C and 2H, respectively. Analysis with carbon-13 nuclear magnetic resonance (13C-NMR) showed that ketal and benzyl ether bonds were formed between α-C of lignin and carbohydrates. The R-LCC and LCC were further treated with enzymes to obtain enzymatic degraded R-LCC (ED-R-LCC) and enzymatic degraded LCC (ED-LCC). 13C-NMR spectra of ED-LCC showed that the α-C of lignin side chain was combined with 6-C of carbohydrates by ether, ester, and ketal linkages. 1H-NMR differential spectra of ED-LCCs revealed an LC linkage of benzyl ether bond. Glucan-lignin (En-R-GL) and xylan-lignin (En-R-XL) complexes were separated from ED-R-LCC by ionic liquid. A part of lignin α-C was linked to cellulose 6-C by benzyl ether and α-ketal linkages. 13C-NMR spectra of En-R-XL showed there were α-benzyl ether and α-ketal bonds between lignin and xylan.
Early diagnosis of pulmonary embolism using deep learning and SPECT/CT Exams Fusion
Authors: Romdhane Hamida , Cherni Mohamed Ali , Sellem Dorra Ben
Published: November 2022

Background: Pulmonary embolism is a serious disease, which can be life-threatening. Its treatment and its detection are sometimes complicated. The two most commonly used imaging techniques are the computed tomography pulmonary angiography and the pulmonary scintigraphy. Currently, hybrid imagery, combining single photon emission computerized tomography and computed tomography (SPECT/CT), play an important role in the diagnosis of pulmonary embolism. Objective: Our aim, in the analytical study, is to detect the pulmonary embolism. A whole new method based on the fusion of SPECT and CT images by the deep Siamese Neural Network is proposed to early detect this fatal disease. Material and methods: This method consists of two main parts: fusion of SPECT and CT images and detection of the pathological lobes. It starts with the segmentation of both SPECT and CT images to obtain 3D binary images. Next, we detect the different pulmonary lobes in the CT images. Then, we merge the two SPECT and CT images by deep Siamese Neural Network. Afterward, they are compared to the image where the different lobes are identified to finally detect the pulmonary embolism and identify the pathological lobes. Results: The validation achieved an accuracy of 90.5%, with a sensitivity of 88.2% and a specificity of 91.5%. Conclusion: The obtained results prove the effectiveness of the proposed method in the detection of pulmonary embolism.