bluuebunny/crossref_metadata_2025 huggingface dataset:
TAVISCORE: a computer program for risk stratification of complications after aortic valve interventions in patients with reduced ejection fraction
Authors: Strelkov D. A. , Zubarev D. D. , Pischugin A. S. , Guryev V. V. , Kulikov D. I. , Postnikova Z. N. , Lening K. S.
Published: February 2023

Aim. To demonstrate the TAVISCORE program designed to stratify the risk of complications after aortic valve (AV) interventions in patients with reduced ejection fraction.

Material and methods. For the period from 2015-2022 at the Almazov Federal North-West Medical Research Center, 128 interventions on AV were performed for aortic stenosis in patients with reduced ejection fraction as follows: 61 — surgical AV replacement (SAVR), 67 — transcatheter aortic valve implantation (TAVI). To create an interactive calculator TAVISCORE (link for free download: https://drive.google.com/file/d/1a3s2MK6Tpk0cIQ_aMB7xe63upEwJsJOh/view?usp=sharing) all patients were combined into one group. For each factor present in the patient, the prognostic coefficient, its contribution to the likelihood of an event in the long-term follow-up period (death, myocardial infarction, stroke), was calculated. The next step, based on the calculations obtained and using the Python 3.10.6 language, was the creation of the TAVISCORE program.

Results. The TAVISCORE was created for the personalized choice of tactics for the treatment of patients with aortic stenosis. It contains 54 risk factors and makes it possible to determine probability of cardiac or non-cardiac events in the long-term follow-up period after SAVR and TAVI. Thus, a tactic with lower probability of a complication can be chosen as optimal in this particular case. Retrospective use of the TAVISCORE after surgery can identify patients at high risk of complications, which will allow them to be selected for more thorough management and more frequent screening.

Conclusion. The TAVISCORE can be used by a multidisciplinary consensus to select the treatment tactics and stratify the risk of complications after different AV replacement variants in patients with a reduced ejection fraction. Further prospective testing of this program is required.
Cardioprotective effect of thiotriazoline in cancer patients
Authors: Koltsov A. V. , Tyrenko V. V.
Published: February 2023

Aim. To evaluate the effectiveness of morpholinium-methyl-triazolyl-thioacetate (thiotriazoline) as a cardioprotector in patients with non-Hodgkin’s lymphomas who received chemotherapy with the inclusion of anthracyclines.

Material and methods. Fifty patients with non-Hodgkin’s lymphomas were examined on the background of antitumor therapy. The patients were divided into 2 following groups: group 1 (n=27) — standard chemotherapy; group 2 (n=23) — thiotriazoline as a cardioprotector. The quality of life was assessed using the SF-36 questionnaire; the level of troponin I and the natriuretic peptide NT-proBNP was determined; an electrocardiography and echocardiography were performed.

Results. In the course of the study, significant differences (p<0,05) were found in following parameters: the severity of dyspnea and lower limb edema, alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, troponin I level, NT-proBNP, corrected QT interval, end systolic volume, left ventricular ejection fraction, E/A ratio. The results obtained indicate the clinical and paraclinical advantage of thiotriazoline and reflect its cardioprotective effect. Conclusion. The use of thiotriazoline makes it possible to prevent and slow down the cardiovascular disease continuum, leading to the development of heart failure or decompensation that exists in this category of patients. Keywords: cardio-oncology, thiotriazoline, heart failure, anthracyclines, cardiotoxicity>˂0,05) were found in following parameters: the severity of dyspnea and lower limb edema, alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, troponin I level, NT-proBNP, corrected QT interval, end systolic volume, left ventricular ejection fraction, E/A ratio. The results obtained indicate the clinical and paraclinical advantage of thiotriazoline and reflect its cardioprotective effect.

Conclusion. The use of thiotriazoline makes it possible to prevent and slow down the cardiovascular disease continuum, leading to the development of heart failure or decompensation that exists in this category of patients.
Classification of heart failure: focus on prevention
Authors: Editorial Article
Published: February 2023

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TNF-α Expression and New Epithelial Thickness in the Skin of Mice (Mus musculus) Infected MRSA by Medical Plasma Treatment
Authors: Darmawati Sri , Hayati Defi Nurul , Kamarudin Mudyawati , Putri Gela Setya Ayu
Published: February 2023

Chronic wounds develop as a result of infection, commonly carried on by bacteria and form biofilms. MRSA is a kind of bacteria that can form biofilms. Recently, medical plasma technology has been applied to accelerate wound healing. The objective of the research was to investigate the response of cutaneous wounds in MRSA-infected animals to contact and non-contact therapy using medical plasma argon jet-type with histopathological and molecular approaches. Argon gas, with a purity of 99.995%, is utilized as a carrier gas for generating plasma medical at a flow rate of 1 standard liter per minute (slm). This experiment was divided into 4 treatment groups, K (infected wound without plasma treatment), CP (5 mm plasma treatment), NCP (20 mm plasma treatment), and CP-NCP (infected wound with 5 mm and 20 mm plasma combination treatment). The result of the observation obtained that contact plasma from day 3 to day 10 can remove bacterial biofilm and that non-contact plasma treatment from day 11 to day 16 is effective to accelerate wound healing. At day 17, the macroscopic biofilm area in the CP-NCP group began to decrease with an increasing percentage of re-epithelialization, and no necrotic cells were observed. TNF-α levels were observed significantly lower in the CP-NCP group at day 17 compared with other groups. In conclusion, contact-non-contact (CP-NCP) treatment is suggested for the management of chronic infections since it is beneficial for removing the bacterial biofilm layer and can promote wound healing.
Influences of business model innovation in entrepreneurial orientation and organizational performance: evidences in supermarkets of Santa Catarina
Authors: Akoumani Messan Komlanvi , Santos Edicreia Andrade dos , Sallaberry Jonatas Dutra
Published: February 2023

The supermarket sector is highly competitive with an intense search for alternatives to overcome business challenges, increase consumption and improve results. In this context, this study analyzed the influences of entrepreneurial orientation on the relationship between business model innovation and organizational performance. To this end, a quantitative, descriptive approach was adopted, and its operationalization took place through a survey with 77 supermarkets, whose data were managed through structural equation modeling. The results reveal that business model innovation does not directly influence organizational performance. Only from the inclusion of entrepreneurial orientation was it possible to reveal the indirect relationship of business model innovation on organizational performance. This evidence reveals that indistinct innovation may not be able to affect performance positively; unplanned innovation can even hurt performance. With this, it is concluded that in a very diverse, competitive segment and direct service to the public, such as the supermarket sector, innovation in the business model may not generate better results. In the non-academic professional scope, the evidence identified allows us to assure the importance of entrepreneurial orientation, and demonstrate that this would be the primary factor to direct innovative efforts and thus improve business performance.
Influências da inovação do modelo de negócios na orientação empreendedora e no desempenho organizacional: evidências nos supermercados catarinenses
Authors: Akoumani Messan Komlanvi , Santos Edicreia Andrade dos , Sallaberry Jonatas Dutra
Published: February 2023

O setor supermercadista é altamente competitivo com intensa busca de alternativas para superar os desafios do negócio, aumentar o consumo e melhorar os resultados. Nesse contexto, este estudo analisou as influências da orientação empreendedora na relação entre a inovação do modelo de negócios e o desempenho organizacional. Para tal, adotou-se uma abordagem quantitativa, descritiva, e sua operacionalização ocorreu por meio de um survey junto a 77 supermercados e cujos dados foram tratados por meio de modelagem de equações estruturais. Os resultados revelam que a inovação do modelo de negócios não influencia o desempenho organizacional diretamente. Somente a partir da inclusão da orientação empreendedora foi possível revelar a relação indireta da inovação do modelo de negócios no desempenho organizacional. Essa evidência revela que a inovação indistinta pode não ser capaz de afetar o desempenho positivamente; uma inovação sem planejamento pode inclusive prejudicar o desempenho. Com isso, conclui-se que num segmento muito diverso, concorrencial e de atendimento direto ao público, como é o setor supermercadista, a inovação no modelo de negócios pode não gerar melhores resultados. No âmbito profissional não acadêmico, as evidências identificadas permitem assegurar a importância da orientação empreendedora, e demonstrar que seria este o fator primordial para direcionar os esforços inovativos e assim melhorar o desempenho do negócio.
Water deficit and salinity modify some morphometric, physiological, and productive attributes of Aloe vera (L.)
Authors: Mota-Ituarte María , Pedroza-Sandoval Aurelio , Minjares-Fuentes Rafael , Trejo-Calzada Ricardo , Zegbe Jorge A , Jesús Josafath Quezada-Rivera
Published: February 2023

Background: Water deficit and salinity are common conditions in arid agro-ecosystems.
Hypothesis: Salinty increases the hydric stress effect on the yield and gel quality of Aloe vera.
Study species and data description: In A. vera plants the variables meassured were: plant height, leaf length, width, and thickness, fresh biomass, the relative content of water, total solids, gel percentage, and harvest index.
Study site and dates: The study was conducted from spring to summer 2020 in Bermejillo, Durango, Mexico.
Methods: A split-block experimental design with four replications was used. The large plots were two soil moisture contents: field capacity (18.5 ± 2.5 %) and permanent wilting point (12.5 ± 2.5 %). The small plot was the salinity, with levels: 0, 20, 40, 60, and 80 mM of NaCl.  
Results:Water deficit and salinity reduced the width and thickness of leaves and, consequently, the fresh biomass and gel percentage were reduced, but gel quality increased.
Conclusions: Water deficit and salinity, mainly the latter, reduced plant growth and leaves, and therefore, the yield of fresh biomass and gel. Although gel yield was reduced, its quality was enhanced, in terms of high total solids content.
Caracterización morfológica y genética de las poblaciones de Abies en Hidalgo, México: importancia de la identidad taxonómica para el aprovechamiento forestal
Authors: Rosales-Islas Elena , Barrera-Tello Daniel , Sánchez-González Arturo , Galván-Hernández Dulce María , Hernández-León Sergio , Octavio-Aguilar Pablo
Published: February 2023

Antecedentes: Abies hidalgensis es una especie endémica del estado de Hidalgo, México, adscrita en la Lista Roja de la IUCN en la categoría VuD2, que se ha confundido con A. guatemalensis en algunas poblaciones donde hay extracción de madera en rollo reportada como A. religiosa, lo que genera duda sobre las o la especie que se distribuyen y aprovechan en el estado de Hidalgo.
Preguntas y / o Hipótesis: ¿Qué especie o especies del género Abies se distribuyen y aprovechan en Hidalgo, México?,¿Cuál es la distribución geográfica de A. hidalgensis?
Especies de estudio: Abies hidalgensis, A. religiosa.
Sitio y años de estudio: Municipios de Acaxochitlán, Acoculco, Agua Blanca de Iturbide, Epazoyucan, Mineral del Monte, Pachuca, Singuilucan, Tenango de Doria, Tepeapulco y Zimapán, en el estado de Hidalgo. Años 2015 a 2017.
Métodos: Se analizaron 18 caracteres morfológicos mediante análisis de funciones discriminantes. Se estimó la diferenciación genética a partir del análisis de tres microsatélites nucleares desarrollados para A. guatemalensis.
Resultados: Abies hidalgensis se distribuye al sureste y Abies religiosa en la zona centro-sur de Hidalgo. Los caracteres morfológicos distintivos son: canales resiníferos, forma del ápice, y caracteres morfológicos asociados a los conos ovulados y las semillas. Los estudios genéticos indican que Abies sp. muestra mayor divergencia y diversidad genética con respecto a A. hidalgensis y A. religiosa. El coeficiente de endogamia es mayor en A. religiosa.
Conclusiones: En el estado Hidalgo se distribuyen dos especies del género Abies.
Electrochemical analysis of laser-inscribed graphene electrodes using cyclic voltammetry (ferri/ferrocyanide redox couple) v1
Authors: Tang Yifan
Published: February 2023

This protocol describes use of the cyclic voltammetry (CV) method for electrochemical analysis of laser-inscribed graphene (LIG) electrodes. The protocol requires approximately 1 hour (excluding electrode fabrication).
Zebrafish larvae dissociation for FACs sorting cells expressing fluorescent proteins v1
Authors: Elliot Abigail
Published: February 2023

Large number of transgenic lines with cell/tissue specific expressing of fluorescent proteins are available in the zebrafish field. These tools provide an opportunity for isolating cell tpe of interest for gene expression analysis. Key to success for a FAC sorting experiment is to generate single cells suspension with maximum number of viable target cells preserved. Here we describe the protocol that we optimized in the lab for generate single cell suspension for FAC sorting cells expressing fluorescent proteins from zebrafish larvae. We used a combination of enzyme digestion ( collagenase IV) and mechanical dissociation ( rapid pipetting) to generate single cell suspension, which achieved the highest number of cell recovery and viable cells. We have used this protocol for larvae at 3, 4, 5 dpf and for downstream single cell RNA sequencing and RNA sequencing analysis.
EUROPEAN BORDER AND COAST GUARD STANDING CORPS CATEGORY 1 BASIC TRAINING TOPICALITIES IN ENSURING THE EU BORDER SECURITY
Authors: Frankowska Iwona
Published: February 2023

Establishment of the European Border and Coast Guard Standing Corps Category 1 has been recently the most visible change in the European approach in the management of the EU external borders. The political decision of the EU to have its own law enforcement officers for border protection and migration management and return-related tasks, has manifested a paradigm shift, also in training and education. The European Border and Coast Guard Agency (Frontex) has a leading role in capacity building, for example in terms of providing training for the members of the Category 1. The Agency Regulation provides a legal basis for the statutory staff of the Standing Corps, in particular highlighting the importance of training based on common values and culture, and respect of fundamental rights. The European dimension of the Standing Corps training is underpinned by the legal and ethical responsibilities of the Agency to ensure that the members of the Standing Corps are well trained and fully prepared to perform tasks with executive powers. The main aim of the paper is to explore the establishment of standing corps from the perspective of basic training. The context presented supports the thesis that the initial training serves as the foundation of public agreement and investment for common safety and security. The paper builds upon hands-on experience of the author and draws the general conclusion to prove the thesis based on the legal instruments presented and implementation of basic training editions.
Late complications of the new coronavirus infection: a clinical case
Authors: Chepurnenko S. A. , Shavkuta G. V. , Demidova A. A.
Published: February 2023

According to the literature, exudative pleurisy and pericarditis are considered rare complications of the new coronavirus infection. This estimation can be explained by the fact that statistical studies cover mainly the hospital treatment of this disease. The true frequency of these complications and their consequences are not fully understood.

Aim. The study of late complications of the new coronavirus infection in the form of pleurisy and pericarditis.

Conclusion. In our case, a 62-year-old patient with the new coronavirus infection confirmed by polymerase chain reaction, severe bilateral polysegmental viral pneumonia, CT3, 60% on day 43 after the onset of clinical symptoms, was found to have manifestations of pleurisy and pericarditis during outpatient treatment. Cardiac MRI is the most informative method for detecting small pericardial and pleural effusions. The diagnostic capabilities of this method are superior to ultrasounography of the heart and pleural cavities and computed tomography of the lungs. Administration of colchicine 1.0 g per day for 1 month allowed not only to the elimination of pericarditis and pleurisy, but also the reduction of pressure in the right ventricle, probably by reducing the damage to the pulmonary parenchyma.
Challenge No.3 Differential diagnosis of cystic lung masses
Authors: Brodskaya O. N. , Soldatov D. G. , Makarova M. A. , Bukhtoyarova N. A.
Published: February 2023

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The inspiratory activity of respiratory center and respiratory muscles strength after COVID-19
Authors: Savushkina O. I. , Zaicev A. A. , Kryukov E. V , Astanin P. A , Aseeva N. A , Malashenko M. M. , Fesenko O. V.
Published: February 2023

The respiratory pump that provides pulmonary ventilation includes the respiratory center, peripheral nervous system, chest and respiratory muscles.

The aim of this study was to evaluate the activity of the respiratory center and the respiratory muscles strength after COVID-19 (COronaVIrus Disease 2019).

Methods. The observational retrospective cross-sectional study included 74 post-COVID-19 patients (56 (76%) men, median age – 48 years). Spirometry, body plethysmography, measurement of lung diffusing capacity (DLCO), maximal inspiratory and expiratory pressures (MIP and MEP), and airway occlusion pressure after 0.1 sec (P0.1) were performed. In addition, dyspnea was assessed in 31 patients using the mMRC scale and muscle strength was assessed in 27 of those patients using MRC Weakness scale.

Results. The median time from the COVID-19 onset to pulmonary function tests (PFTs) was 120 days. The total sample was divided into 2 subgroups: 1 – P0.1 ≤ 0.15 kPa (norm), 2 – > 0.15 kPa. The lung volumes, airway resistance, MIP, and MEP were within normal values in most patients, whereas DLCO was reduced in 59% of cases in both the total sample and the subgroups. Mild dyspnea and a slight decrease in muscle strength were also detected. Statistically significant differences between the subgroups were found in the lung volumes (lower) and airway resistance (higher) in subgroup 2. Correlation analysis revealed moderate negative correlations between P0.1 and ventilation parameters.

Conclusion. Measurement of P0.1 is a simple and non-invasive method for assessing pulmonary function. In our study, an increase in P0.1 was detected in 45% of post-COVID-19 cases, possibly due to impaired pulmonary mechanics despite the preserved pulmonary ventilation as well as normal MIP and MEP values.
Bronchodilator therapy in patients with chronic obstructive pulmonary disease: what should be considered in clinical practice when choosing a dosing regimen?
Authors: Titova O. N. , Kuzubova N. A. , Kozyrev A. G. , Shumilov A. A.
Published: February 2023

The use of long-acting bronchodilators is central to the chronic obstructive pulmonary disease (COPD) therapy. One of the goals of bronchodilation is to reduce the morning COPD symptoms that are associated with a more severe disease and an increased risk of exacerbations.

The aim of the study was to evaluate the clinical efficacy of switching COPD patients with severe morning symptoms who received combinations of long-acting bronchodilators QD to a fixed-dose combination of aclidinium bromide (AB) and formoterol fumarate (FF) BID.

Methods. We examined COPD patients treated with combinations of long-acting β2-agonists and M-anticholinergics (but not AB and FF), who continued to complain of severe symptoms in the morning despite the treatment. After examination, the patients were switched to the fixed-dose combination of AB 0.4 mg and FF 0.012 mg (AB/FF) BID in the form of a metered-dose powder inhaler. The patients were examined at baseline and at 6-month follow-up.

Results. Of the 115 included COPD patients, 90 completed the study. After 6 months of treatment, they showed a significant decrease in the intensity of cough, sputum amount, severity of distant wheezing, and shortness of breath in the morning (–0.88, –0.38, –0.29, –0.58 on a 4-point scale, the mean score –0.44; p < 0.001). The result of the COPD Assessment test decreased from 28 (24; 34) to 24 (20; 28) (p = 0.011), the distance of a 6-minute walk increased from 319 ± 72 to 354 ± 67 m (p < 0.001). The fixed-dose combination of AB/FF did not cause serious adverse events.

Conclusion. The fixed-dose AB/FF combination in COPD patients resulted in a significant clinical improvement and was well tolerated. The AB/FF combination with twice daily dosing regimen is advisable for the patients with morning symptoms persisting despite therapy with other combinations of long-acting bronchodilators with once daily dosing regimen.
Efficacy and safety of bovhyaluronidase azoximer (Longidase) in patients with post-COVID syndrome: results of an open, prospective, controlled, comparative, multicenter clinical trial DISSOLVE
Authors: Chuchalin A. G. , Yablonskiy P. K. , Rubanik T. V. , Chernyavskaya O. A. , Naumov V. V. , Korneva L. I. , Kudelуa L. M. , Petukhova A. Yu. , Masalkina O. V. , Argamakova Yu. V. , Ignatova G. L. , Borisov A. G. , Kasyanova T. R. , Suleymanova A. K.
Published: February 2023

Post-COVID syndrome develops after COVID-19 (COronaVIrus Disease 2019) and leads to cumulative effects in the form of shortness of breath and impaired lung function. Notably, patients with airway inflammation and COVID-19 were found to have increased concentrations of hyaluronic acid (HA). Since bovhyaluronidase azoximer (Longidase®) catalyzes the hydrolysis of HA, this drug has the potential to reduce HA levels and improve lung function in patients with post-COVID syndrome.

The aim of the DISSOLVE trial, which was conducted early in the pandemic, was to investigate the efficacy and safety of bovhyaluronidase azoximer in patients with symptoms associated with post-COVID syndrome.

Methods. An open, prospective, controlled, comparative, multicenter clinical trial (NCT04645368) included adult patients (n = 160) who had post-COVID syndrome. Patients in the treatment group (n = 81) received bovhyaluronidase azoximer, and individuals in the control group (n = 79) were followed up without intervention. The study included physical examination, evaluation of forced vital capacity (FVC), assessment of dyspnea with the Modified Medical Research Council Dyspnea Scale (mMRC), 6-minute walking test, and pulse oximetry. These indicators were measured on 3 visits, at days 1 (baseline), 75, and 180. In addition, the number of patients who experienced adverse events and serious adverse events were recorded.

Results. Baseline patient characteristics in the treatment group and the control group were similar. In the treatment group, there was a statistically significant reduction in residual pulmonary abnormalities after visit 2 (day 75) and visit 3 (day 180). In addition, FVC, pulse oximetry values, and functional exercise tolerance increased statistically significantly at days 75 and 180 compared to baseline. The mMRC scores for dyspnea decreased statistically significantly in the treatment group over 75 days. The safety profile of the drug was reported to be favorable throughout the study.

Conclusion. Treatment with bovhyaluronidase azoximer in patients with post-COVID syndrome showed improvement in FVC, pulse oximetry, functional exercise tolerance, and mMRC dyspnea.
Study of human ribosomal gene complex in cystic fibrosis
Authors: Kondratyeva E. I. , Ershova E. S. , Nikolaeva E. D. , Veyko N. N. , Sherman V. D. , Mel’yanovskaya Yu. L. , Krasovskiy S. A. , Kostyuk S. V.
Published: February 2023

Increasing the life expectancy of patients with CF is an urgent healthcare task all over the world. According to the Register of patients with cystic fibrosis in the Russian Federation (2020), the number of patients over 18 years of age is 26.5%. Assumably, cystic fibrosis can be used as a model of accelerated aging to study the aging process in general.

Aim of the study was to analyze the number of rDNA copies in a sample of cystic fibrosis patients at different ages and with lethal outcome in relation to lung function, complications, and respiratory tract infections.

Methods. We studied DNA samples isolated by the standard method from peripheral blood leukocytes of 277 patients diagnosed with cystic fibrosis. 998 DNA samples from healthy volunteers were used as a control group.

Results. The study showed that the genomes of patients with CF contain more rDNA copies than those of control patients. The greatest number of copies of ribosomal genes was observed in DNA samples from deceased patients (p < 0.001) and was associated with more severe disease course. Among all CF patients, the largest number of rDNA copies in the genome was registered in patients with the lowest FEV1 values (less than 40%). It was found that patients with chronic Burkholderia cepacia complex infection had a significantly higher number of copies of ribosomal repeats than the total sample (p = 0.001) and the adults (p = 0.014). The number of ribosomal repeats did not differ between patients with other chronic respiratory tract infections.

Conclusion. In the group of deceased patients, the patients with low respiratory function and Burkholderia cepacia complex infection had the highest number of rDNA copies in the genome, and the differences were significant. It can be assumed that the number of rDNA copies in the genome of CF patients is an additional prognostic marker that is associated with the patient’s life expectancy.
Treatment, diagnostics, and management of chronic obstructive pulmonary disease in women
Authors: Malykhin F. T. , Baturin V. A.
Published: February 2023

Chronic obstructive pulmonary disease (COPD) poses a significant burden on women’s health. Insufficient attention is paid to this problem in scientific research and in clinical practice, although more and more information surfaces about the gender-associated differences in the treatment, diagnostics, and management of COPD.

The aim of the review is to consider the most significant data currently available on the clinical signs, course, and outcomes of COPD in women and propose ways to achieve the best results in the diagnosis and treatment of this disease.

Conclusion. There are biological and cultural differences between the clinical manifestations, course and outcome of COPD in men and women, and these differences impact the clinical practice. It is advisable to apply individualized diagnostic, organizational, and pharmacotherapeutic approaches to COPD in women, based on the knowledge of female-specific variances in the symptoms of the disease and the health status.
On the pathogenesis of destructive pneumonia during COVID-19: a clinical case
Authors: Zaytseva O. V. , Tolstova E. М. , Khaspekov D. V. , Tkachenko N. V. , Scholohova N. A. , Simonovskaya H. Yu. , Belyaeva Т. Yu.
Published: February 2023

Community-acquired pneumonia is a potentially serious infection in children with high morbidity rate, risk of severe course and unfavorable outcomes. Specialists have noted the increased incidence of the destructive forms in the recent years.

Aim. To present a clinical case of destructive pneumonia in a 1 year 2 month old child, hospitalized in the State Budgetary Healthcare Institution “Children’s City Clinical Hospital of St. Vladimir Moscow Healthcare Department”, and analyze it in terms of current understanding on the disease pathogenesis.

Conclusion. During COVID-19 (COronaVIrus Disease 2019) pandemic, pulmonologists and pediatric surgeons encountered an unconventional course of destructive pneumonia. A large number of studies of pathophysiological processes in acute viral interstitial pneumonias have recently allowed to expand our understanding of the role of coagulation system. At the same time, new questions arose concerning the clinical course and development of the pathological infectious process.
Organization of biological therapy for patients with severe eosinophilic bronchial asthma in the Krasnoyarsk region
Authors: Demko I. V. , Sobko E. A. , Kraposhina A. Yu. , Shestakova N. A.
Published: February 2023

Patients with severe bronchial asthma, which remains uncontrolled despite the optimal basic therapy, carry a significant healthcare burden and require substantial financial investments. Severe asthma is a heterogeneous airway disease with complex pathophysiological mechanisms that can be broadly divided into inflammatory pathways with eosinophilic and non-eosinophilic inflammation.

Aim. This study aimed to analyze the literature data on the use of targeted genetic engineering therapy in patients with severe bronchial asthma, as well as to analyze the organization of immunobiological therapy in the Krasnoyarsk Territory. The addition of targeted drugs for severe eosinophilic bronchial asthma based on phenotyping has proven to be effective and is recommended by all current guidelines. Today, several biologics targeting specific endotypes and phenotypes has been approved for the treatment of severe eosinophilic asthma worldwide. These are antibodies binding immunoglobulin E (omalizumab), antagonists of interleukin-5 (mepolizumab, reslizumab) and its receptor (benralizumab), as well as antibodies selectively binding to the IL-4 and IL-13 receptors (dupilumab). Eosinophilic inflammation therapy is a relatively new direction of asthma treatment, and understanding its long-term efficacy and safety is important.

Conclusion. It is essential to differentiate patients with severe eosinophilic asthma from the general cohort of asthma patients, timely refer them to specialists who can prescribe this therapy and have experience with it, select the drug correctly, and monitor the patients during the treatment. This article describes organization of biological therapy for patients with severe eosinophilic bronchial asthma in the Krasnoyarsk Territory.
Inhaled corticosteroids administration/withdrawal as a therapeutic continuum for patients with chronic obstructive pulmonary disease in real clinical practice
Authors: Avdeev S. N. , Aisanov Z. R. , Arkhipov V. V. , Belevskiy A. S. , Vizel A. A. , Demko I. V. , Emelyanov A. V. , Zaycev A. A. , Ignatova G. L. , Kniajeskaia N. P. , Kudelya L. M. , Leshchenko I. V. , Ovcharenko S. I. , Sinopalnikov A. I. , Trofimenko I. N. , Fedotov V. D. , Khamitov R. F.
Published: February 2023

Chronic obstructive pulmonary disease (COPD) is a progressing disease. Each exacerbation impairs the patient’s prognosis and increases burden for the healthcare system. The most common maintenance treatment options for COPD include long-acting bronchodilators – β2-agonists (LABA) and long-acting antimuscarinic agents (LAMA), and inhaled glucocorticosteroids (ICS), in fixed/opened double and triple combinations. Triple therapy in subjects with exacerbation history is the most effective way to prevent negative outcomes of the disease. It can reduce the frequency of exacerbations, slow down the disease progression, improve quality of life, and reduce mortality in the long run. On the other hand, the response to triple therapy may change over the time depending on airways inflammation level, infection activity, and exacerbation frequency. Current COPD guidelines propose different indications for therapy escalation and de-escalation (ICS addition/withdrawal) for more personalized and safe treatment. At the same time, many practical issues of this process are still unclear, e.g. how often treatment regimens should be reviewed and what escalation/de-escalation criteria should be prioritized. The authors strongly believe that COPD therapy should adapt a holistic treatment approach (continuum) with quick responses to any changes in the patient’s condition.

The aim of our work was to create an algorithm for ICS administration/ withdrawal for COPD patients on long-acting dual bronchodilators maintenance therapy and to establish a therapeutic continuum that takes into account exacerbation history, symptoms severity, blood eosinophilia level, and concomitant asthma.

Conclusion. This instrument can be a useful and convenient tool for long-term patient management when access to specialized medical care might be restricted. It takes into account the main current recommendations for COPD management and is easy to apply in real clinical practice.
Issues and Responses for Asia Pacific Digital Trade Activation
Authors:   Korean Academy Of International Commerce, Inc., Han Nak-hyun
Published: February 2023

Purpose : This paper addresses emerging topics in designing effective and appropriate policy responses with limited existing regulations in place and with clear challenges ahead that effectively address movement of data and data localization.
Research design, data, and methodology : In this study, a literature research method is adopted mainly to analyze the response to digital trade in the Asia-Pacific region.
Results : Effective and efficient regulatory policies can support continuing economic growth in the digital economy. Poorly managed or badly implemented policies, by contrast, can easily disrupt the continuing growth of digital trade. In particular, problematic policies and regulations can make it difficult or impossible for the smallest firms in Asia to continue to share in the fastest growing sectors of the economy.
Conclusions : Given the overwhelming importance of small firms to every country in Asia, failure to create supportive policies for micro, small, and medium enterprises (MSME) will impede the region’s attempts to create sustainable and inclusive trade for the future. Digital trade is the future of trade. It binds countries together. Done well, it allows the smallest firm the opportunity to become a micro-multinational company with customers and suppliers around the globe. Done poorly, digital policies can trap firms and customers into sub-standard outcomes.
The Effect of Internal Marketing on Service Quality from Domestic Transportation Logistics Companies: Mediation of Job Satisfaction and the Moderating Effect of Self-efficacy
Authors:   Korean Academy Of International Commerce, Inc., Noh Jin-Ho , Kim Jeong-Hwan
Published: February 2023

Purpose : The purpose of this study is to analyze the effect of internal marketing on employee job satisfaction and service quality, as well as the moderating effect of self-efficacy and the mediating effect of job satisfaction, by targeting logistics companies.
Research design, data, and methodology : A questionnaire targeted logistics companies registered with the Korea Integrated Logistics Association. Analysis of demographics is implemented utilizing IBM SPSS 27.0, and analysis is performed using Smart PLS 3.0.
Results : Analysis found that among the internal marketing factors of logistics companies, all variables except the compensation system had a significant effect on job satisfaction, and job satisfaction factors had a significant effect on service quality. In addition, among the internal marketing factors of logistics companies, all variables except educational training have a significant effect on service quality. Among internal marketing factors, educational training and empowerment variables appear to have moderating effects on self-efficacy, and all variables among internal marketing factors (except compensation systems) appear to have a mediating effect on job satisfaction.
Conclusions : Logistics companies should inform employees of the organization's common goals and values through educational training. They should provide support from various management levels, and grant decision-making rights within a certain range for smooth internal communication, providing an environment that employees can work in with a sense of responsibility.
A Study on the Activation Policy for Yeosu Oil Hub Using AHP
Authors:   Korean Academy Of International Commerce, Inc., Chen Maowei , Lee Hyangsook , Yun Kyongjun
Published: February 2023

Purpose : The purpose of this study is to suggest strategies to activate the oil hub in the port of Yeosu by using Analytic Hierarchy Process(AHP) analysis.
Research design, data and methodology : This paper derives operational strategies for the Yeosu port oil hub through a literature review and expert opinions. Then, the AHP investigation was conducted with 30 experts.
Results : AHP survey results, show that ‘infrastructure construction’ was evaluated as the most important major category, followed by ‘policy improvement and preparation’ and ‘business environment creation’. The important sub-categories are 'securing public berthing facilities'. securing public oil ternimals, and 'Expanding the oil hub hinterland'.
Conclusions : The construction of berthing facilities and oil terminals is most urgent in order to revitalize the oil hub in the port of Yeosu. It is also necessary to improve regulations and prepare support policies.
OBSERVATÓRIO DE CIDADES - Relatório das Cidades do Corede Serra
Authors: Cristina Fachinelli Ana , Paese Giacomelo Cíntia , Libardi Bianca , de Lucena Perini Rafael , de Atayde Moschen Suane , Luis Notari Daniel , Bebber Suelen , Benetti Correa da Silva Marcelo , Suzin Thais , Dalla Santa de Carvalho Mayron , Ferrigo Samuel , Nesello Priscila , de Tomasi Ribeiro Vinícius
Published: February 2023

A utilização de dados para a tomada de decisão sempre foi, em grande medida, adotada pelas corporações empresariais e, nas últimas décadas, pelas gestões das cidades. A elaboração do Plano Plurianual e demais Planos das diversas dimensões do desenvolvimento contam com os dados das diversas plataformas de dados setoriais do governo estadual e federal. Com recursos da Consulta Popular e acompanhamento da Secretaria Estadual de Inovação, Ciência e Tecnologia foi possível disponibilizar aos gestores municipais uma única plataforma onde é possível verificar 68 indicadores que traduzem a fotografia atual dos ODS – Objetivos do Desenvolvimento Sustentável, dos indicadores que mostram o que é uma cidade inteligente (baseada na ISO 37.122) e os indicadores que mostram os capitais existentes nas cidades e que possibilitam a estruturação de redes que apoiam o desenvolvimento. Além dos indicadores oficiais, a plataforma disponibiliza dados de percepção dos cidadãos do COREDE SERRA. Foram mais de 1500 respondentes, que expuseram as suas percepções sobre aspectos de suas cidades nos três diferentes modelos: ODS, Cidades Inteligentes e Sistema de Capitais. Será possível olhar para cada cidade e compará-la com cidades vizinhas, com a região, com o estado do RS e com o país. Caso a cidade decida perseguir os indicadores da cidade mais bem colocada numa determinada variável, haverá possibilidade de criar estratégias para alcançar tais indicadores. Neste momento em que a UCS - Universidade de Caxias do Sul oferece o Observatório das Cidades aos gestores municipais, o COREDE SERRA sente-se honrado por ter possibilitado esta construção, no momento da escolha do projeto. Entende que os números em si são altamente relevantes para o planejamento do futuro que se deseja. Associar a análise dos dados a Pareceres do grupo de especialistas envolvidos com o Observatório demonstrará, de fato, a integração entre a UCS e o setor público buscando elevar, ainda mais, o compromisso com o desenvolvimento regional. O Observatório de Cidades agregará, no curto prazo, muitas possibilidades de apoio à construção de Planos de Desenvolvimento Locais estruturados e baseados no estado da arte. Nossa expectativa é que agentes públicos, instituições, cidadãos e o setor empresarial se apropriem das informações para que, em aliança, se busque qualificar as cidades para atendimento de uma sociedade em profunda transformação. Este relatório vem em complemento à Plataforma Web do Observatório de Cidades, trazendo uma versão resumida dos dados da região.
Distribuição espacial de casos da Doença Falciforme em um estado do sul do Brasil com base no Componente Especializado da Assistência Farmacêutica
Authors: Roman Cassiela , Bueno Denise
Published: February 2023

A doença falciforme é considerada a doença genética com maior prevalência mundial, configurando-se como um grave problema de saúde pública devido a sua relevância clínica e morbimortalidade da população acometida. Por ser associada a questões de vulnerabilidade social por vezes torna-se invisível no território, dificultando a gestão do cuidado em saúde de forma longitudinal. Este estudo objetivou identificar os pacientes com doença falciforme e verificar a sua distribuição espacial no Rio Grande do Sul. Estudo descritivo com desenho transversal, realizado por meio da coleta de dados do Componente Especializado da Assistência Farmacêutica do estado. Tendo por base os CIDs contemplados no protocolo clínico para a doença foi possível verificar os pacientes com cadastro ativo para acesso aos medicamentos deste componente utilizados no seu tratamento. Os dados coletados indicaram que 194 pacientes possuem cadastro ativo, sendo que 98% destes fazem uso do medicamento hidroxiureia. Em relação à frequência dos casos conforme o CID, 84% dos pacientes apresentam anemia falciforme e 11% talassemia beta. O sexo feminino foi prevalente no estudo (53%), bem como os pacientes na faixa etária de 10 a 19 anos. Ao todo, 69 municípios possuem um ou mais pacientes com a doença, com destaque para Porto Alegre que engloba 35% dos casos. A distribuição espacial se dá de forma heterogênea no estado, tendo um aglomerado relevante na região metropolitana. Percebendo-se que o geoprocessamento pode atuar de maneira estratégica para a identificação geográfica de pacientes com doença falciforme e que a assistência farmacêutica tem participação importante neste processo.
Vivência na oficina de capacitação das Policlínicas: refletindo o impacto desse serviço na rede de saúde.
Authors: Madureira Gabriella de Carvalho
Published: February 2023

Objetivo: Relatar a experiência na oficina de capacitação da Policlínica, ocorrida na cidade de Feira de Santana, Bahia, Brasil. Metodologia: O evento foi conduzido por funcionários da Secretaria Estadual de Saúde, onde se explanou sobre o funcionamento desse serviço, discussão do protocolo de encaminhamento da Policlínica e discussão de casos. Resultados: Os principais resultados indicam uma boa expectativa sobre o serviço, já que os profissionais acreditam que haverá mais vagas para a população, e também muitas dúvidas sobre o funcionamento, e, se de fato o serviço causará mudanças a longo prazo. O confronto desses resultados com a revisão da literatura científica, aponta resultados pouco animadores, visto que as experiências semelhantes em outros municípios foram pouco exitosas graças a aspectos conjunturais que perduram no sistema de saúde. Conclusão: É necessário refletir se o atual contexto da saúde favorece operacionalizar o potencial da policlínica, ou, se essa será mais um ponto da rede de saúde que enfrentará os entraves já existentes.
Emigração médica em Portugal: causas e efeitos para o Serviço Nacional de Saúde
Authors: Nunes Alexandre Morais
Published: February 2023

Objetivos: identificar as causas que desencadearam a emigração e os fatores que podem afetar a decisão para retornar ao país de formação. Métodos: estudo exploratório-descritivo, de abordagem qualitativa, realizado com recurso a entrevista semiestruturada gravada aplicada a 50 jovens médicos que manifestaram intenção de emigra. A coleta de dados ocorreu entre setembro e dezembro de 2016, sendo utilizada para a análise a técnica da análise de conteúdo. Resultados: verificou-se que, para 88% dos entrevistados, a ideia de emigrar é motivada por desmotivação generalizada com o estado da profissão em Portugal, causada por fatores relacionados com a proprio processo de formação (90%), pela falta de estabilidade e perspectivas de futuro (100%), por fatores relacionados com a remuneração (100%) e pelas condições de trabalho precárias oferecidas no Serviço Nacional de Saúde (60%). Apenas 20% dos entrevistados admite retornar, um dia mais tarde, ao país que o formou. Conclusões: Os médicos internos com intenção de emigrar sentem uma forte desmotivação que já levou para fora do país mais de 800 jovens médicos em pleno período de crise econômica (entre 2013 e 2015). O presente estudo coloca um problema existente não apenas em Portugal como em outros países e reflete a necessidade de promover medidas urgentes para reverter essa tendência. Um dos efeitos mais graves é o risco de faltarem médicos em algumas áreas, comprometendo o acesso e a cobertura universal do Serviço Nacional de Saúde.
New international federation of gynecology and obstetrics (FIGO) staging classification for cancer of the ovary, fallopian tube, and peritoneum
Authors: Arko Darja , Gajser Verena , Takač Iztok
Published: February 2023

The new staging system for cancer of the ovary, fallopian tube, and peritoneum (last revision, 1988) was approved under the auspices of the International Federation of Gynaecology and Obstetrics (FIGO) in 2012. Previously, peritoneal cancer did not have a staging system. The new classification has been valid since January 2014.New findings and a more complete understanding of the molecular pathogenesis underlying ovarian cancer, combined with scientific discoveries identifying prognostic factors have led to changes in the new FIGO classification system. Based on the same symptomatology, treatment, and prognosis, it was established that a lot of similarities are shared between ovarian cancer, primary fallopian tube cancer, and primary peritoneal cancer.
Necrotizing fasciitis in the form of Fournier gangrene in a 70 year old patient
Authors: Arslani Nuhi , Mikuljan Timotej
Published: February 2023

Purpose: In this case report, we describe a patient with Fournier gangrene, as well as his treatmentcourse and management.

Case report: A 70-year-old male was hospitalized for Fournier gangrene in the perianal region. We performed radical necrectomy, drainage of perianal abscess, and transversostomy. Based on wound culture results, Amoksiklav and Ciprobay were administered. The complication of decompensated adhesive ileus occurred, which required reoperative intervention.

Conclusion: Fournier gangrene is a rare disease that usually affects males. The disease begins withswelling, cellulitis, fever, and odor. We successfully treated this disease with emergency surgery and reoperative intervention.
Unintentional common carotid artery cannulation during attempted internal jugular venous catheter insertion
Authors: Janež Jurij , Marksl Janež Dragica
Published: February 2023

Purpose: Insertion of a central venous catheter is a common procedure, performed by anesthesiologists and other medical professionals. The preferred site for central venous cannulation is the right internal jugular vein.

Case Report: We present the case of a male patient who underwent renal transplantation for end-stage renal disease. During preparation for surgery, the right common carotid artery was cannulated instead of the right internal jugular vein. The situation was immediately recognized and managed by a vascular surgeon. The patient recovered completely without neurological deficit.

Conclusion: Central venous cannulation is usually performed using the landmark technique. Incidental cannulation of the common carotid artery is a rare complication that can have serious consequences if not immediately recognized and properly managed.