bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Lewis Acids on the Catalyst Activity for Alkene Metathesis, Z-/E- Selectivity and Stability of Tungsten Oxo Alkylidenes
Authors: Merino J. Haydée , Bernad Jesús , Solans-Monfort Xavier
Published: November 2021

Lewis acids increase the catalytic activity of classical heterogeneous catalysts and molecular d0 tungsten oxo alkylidenes in a variety of olefin metathesis processes. The formation of labile adducts between the metal complex and the Lewis acid has been observed experimentally and suggested to be involved in the catalyst activity increase. In this contribution, DFT (M06) calculations have been performed to determine the role of Lewis acids on catalyst activity, Z-/E- selectivity and stability by comparing three W(E)(CHR)(2,5-dimethylpyrrolide)(O-2,6-dimesithylphenoxide) (E = oxo, imido or oxo-Lewis acid adduct) alkylidenes. Results show that the formation of the alkylidene—Lewis acid adducts influences the reactivity of tungsten oxo alkylidenes due to both steric and electronic effects. The addition of the Lewis acid on the E group increases its bulkiness and this decreases catalyst Z-selectivity. Moreover, the interaction between the oxo ligand and the Lewis acid decreases the donating ability of the former toward the metal. This is important when the oxo group has either a ligand in trans or in the same plane that is competing for the same metal d orbitals. Therefore, the weakening of oxo donating ability facilitates the cycloaddition and cycloreversion steps and it stabilizes the productive trigonal bipyramid metallacyclobutane isomer. The two factors increase the catalytic activity of the complex. The electron donating tuneability by the coordination of the Lewis acid also applies to catalyst deactivation and particularly the key β-hydride elimination step. In this process, the transition states show a ligand in pseudo trans to the oxo. Therefore, the presence of the Lewis acid decreases the Gibbs energy barrier significantly. Overall, the optimization of the E group donating ability in each step of the reaction makes tungsten oxo alkylidenes more reactive and this applies both for the catalytic activity and catalyst deactivation.
Life Satisfaction and Character Strenghs in Ecuatorian Adolescents
Authors: Yépez-Tito Paula , Ferragut Marta , Cóndor-Guerrón Shally , Blanca Maria J.
Published: November 2021

There is empirical evidence that life satisfaction (LS) in adolescence is associated with adequate development and future well-being. Research into the factors underpinning LS can therefore help to promote healthier development of societies. The aim of this study was to extend knowledge about LS among adolescents in Ecuador, a Latin American country for which research on this topic is lacking. Specifically, we analyze the relationship between LS and character strengths, controlling for gender, age, socioeconomic status, and family structure. Participants were 659 adolescents (43.1% female) aged between 12 and 18 years who completed the Students’ Life Satisfaction Scale (SLSS) and the Values in Action Inventory of Strengths for Youth (VIA-Y). Their parents or legal guardians completed the Survey of Socioeconomic Stratification (SSES). Correlation analysis and regression modeling were performed. Results showed that LS was not related to age or socioeconomic status, but there was a significant association with gender and family structure, insofar as boys and adolescents living in intact families reported higher levels of LS. Overall, the majority of character strengths were positively related to LS. After eliminating overlap between strengths and controlling for sociodemographic variables, the strengths of hope, zest, love, and prudence significantly predicted LS. We discuss how these strengths, related to the cognitive component of well-being, may play a protective role against difficulties during adolescence. Character strengths-based interventions are proposed to promote healthy development in Ecuadorian adolescents.
Video-based visual feedback to enhance motor learning in physical education—a systematic review
Authors: Mödinger Moritz , Woll Alexander , Wagner Ingo
Published: December 2021

While studies have indicated that visual feedback promotes skill acquisition and motor learning in controlled settings and for various sports, less is known about its feasibility in physical education, which has specific needs and conditions. For this reason, a systematic literature review was conducted regarding video-based visual feedback in physical education. Out of 2030 initially examined studies, 11 matched the selection and quality criteria. The goal was to determine whether visual feedback can be effective regarding motor learning in physical education in primary and secondary schools, and to investigate whether different visual feedback variants (expert modeling and self-modeling), supported by verbal feedback, are more effective than verbal feedback alone. Subsequently, the different conditions (e.g., age, group size, duration) of the included studies were evaluated for their suitability for everyday applications. Video-based visual feedback seems to be effective to enhance motor learning in physical education and seems to be more effective than solely verbal feedback. However, the results show that the specific conditions (class size, scheduled lessons, available time, technical equipment, the digital literacy of teachers, and data protection) of a school environment must be considered before implementing visual video feedback in daily practice.
Parameters Development for Optimum Deposition Rate in Laser DMD of Stainless Steel EN X3CrNiMo13-4
Authors: Dalaee Mohammad , Cerrutti Eduardo , Dey Indira , Leinenbach Christian , Wegener Konrad
Published: December 2021

Laser Direct Metal Deposition (DMD) has been developed as a manufacturing process to deposit coatings on existing materials and proves advantageous in Additive Manufacturing (AM) of complex and precise components. However, it is necessary to carefully determine the proper process parameter combinations to make this method economically viable for industries. The intent of this study is to address enhancement in productivity of laser DMD of stainless steel EN X3CrNiMo13-4. Accordingly, the effects of the main laser process parameters of laser power P, scan speed v, powder flow rate $$\dot{\mathrm{m}}$$

m
˙

, and spot diameter s on track geometries and build-up rate are discussed. The regression analysis is conducted to derive correlations between the combined set of main parameters and deposition rate. The results show a good linear regression correlation of R2 >0.9 for the geometrical characteristic of aspect ratio, dilution, and deposition rate. The constructed processing map, using linear regression equations, presents proper process parameters selection in connection with deposition rate, aspect ratio, and dilution rate.
Die Anwendung naturwissenschaftlicher Untersuchungsmethoden inklusiv gestalten – Naturwissenschaftsdidaktische Theorie und Empirie erweitern mit dem Kategoriensystem inklusiver naturwissenschaftlicher Unterricht (KinU)
Authors: Brauns Sarah , Abels Simone
Published: December 2021

Zur Verknüpfung von etablierten und typischen Themenfeldern des naturwissenschaftlichen Unterrichts mit inklusiver Pädagogik wurde ein systematisches Literaturreview zur Ableitung des umfassenden Kategoriensystems inklusiver naturwissenschaftlicher Unterricht (KinU) durchgeführt. In einer vorherigen Publikation sind das detaillierte methodische Vorgehen sowie die methodische Diskussion zur besseren intersubjektiven Nachvollziehbarkeit veröffentlicht (www.leuphana.de/inclusive-science-education). In diesem Artikel wird das Kategoriensystem inhaltlich diskutiert, inwieweit sich die Ergebnisse und Implikationen aus der Literatur zur Umsetzung inklusiven naturwissenschaftlichen Unterrichts mit den Erkenntnissen aus der naturwissenschaftsdidaktischen Theorie und Empirie ohne expliziten Inklusionsbezug überschneiden oder diese ergänzen. Der Vergleich wird exemplarisch zu „naturwissenschaftliche Untersuchungsmethoden inklusiv gestalten“ durchgeführt, was mitn = 126 Kategorien die größte der 16 Hauptkategorien des KinU (N = 935) darstellt. Dieser Vergleich wird entlang von Aktionen, Ausführungsformen, Funktionen, experimenteller Kompetenz und Offenheit naturwissenschaftlicher Untersuchungsmethoden strukturiert. Die Ergebnisse zeigen, dass in der naturwissenschaftsdidaktischen Theorie und Empirie ohne expliziten Inklusionsbezug der naturwissenschaftsbezogene Gegenstandsbereich detailliert beschrieben wird und die Anforderungen an die Schüler*innen bzgl. dieses Gegenstands herausgestellt werden. Um inklusiven naturwissenschaftlichen Unterricht zu bestimmen, ist es notwendig, konkrete Zugänge speziell für etablierte und typische Themenfelder des naturwissenschaftlichen Unterrichts zu schaffen. Ein wesentlicher Mehrwert zu der allgemein naturwissenschaftsdidaktischen Literatur liegt darin, dass in den Publikationen mit Inklusionsbezug beschrieben wird, wie der naturwissenschaftliche Gegenstand modifiziert werden kann und welche zusätzlichen Angebote gemacht werden können, damit alle Schüler*innen an diesem Gegenstand mit dem Ziel der naturwissenschaftlichen Grundbildung partizipieren können. Die konkreten Erweiterungen diesbezüglich werden entlang des KinU zusammengefasst dargestellt.
Potential of Mechanochemically Activated Sulfidic Mining Waste Rock for Alkali Activation
Authors: Niu He , Adrianto Lugas Raka , Escobar Alexandra Gomez , Zhukov Vladimir , Perumal Priyadharshini , Kauppi Janne , Kinnunen Paivo , Illikainen Mirja
Published: December 2021

Sulfidic mining waste rock is a side stream from the mining industry with a potential environmental burden. Alkali activation is a promising method for transforming mining waste into construction materials. However, the low reactivity of minerals can be a sizeable challenge in alkali activation. In the present study, the reactivity of waste rock was enhanced by mechanochemical treatment with a LiCl-containing grinding aid. X-ray diffraction (XRD) and diffuse reflectance infrared Fourier transform (DRIFT) analysis were utilized to display the structural alteration of individual minerals. A schematic implication of the grinding mechanism of mica was provided according to the results of transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The alkaline solubility displayed the enhanced chemical reactivity of the waste rock, in which Si and Al solubility increased by roughly 10 times and 40 times, respectively. The amorphization of aluminosilicate is achieved through chemical assisted mechanochemical activation. Sulfidic waste rock, as the sole precursor in alkali activation, achieved a 28-day compressive strength exceeding 10 MPa under ambient curing conditions. The simulation of the upscaled grinding process was conducted via the HSC Chemistry® software with a life-cycle assessment. The results showed that mining waste rock can be a promising candidate for geopolymer production with a lower carbon footprint, compared to traditional Portland cement.

Graphical Abstract
Effects of an individualised nutritional intervention to tackle malnutrition in nursing homes: a pre-post study
Authors: Seemer J. , Kiesswetter E. , Fleckenstein-Sußmann D. , Gloning M. , Bader-Mittermaier S. , Sieber C. C. , Sixt B. , Wurm S. , Volkert D.
Published: December 2021

Purpose

Individualised interventions are recommended to tackle malnutrition in older adults, but approaches for nursing home (NH) residents are scarce. This study investigated the effects of an individualised nutritional intervention in NH residents with (risk of) malnutrition.

Methods

In a pre-post study, 6 weeks (w) of usual care were followed by 6w of intervention. The intervention consisted of up to three supplement modules (sweet and savoury protein creams and protein-energy drink, single or combined) and, if required, reshaped texture-modified meals (RTMM).

Results

Fifty residents completed the study (84 ± 8 years, 74% female). One-third (32%) received RTMM. Additional 258 ± 167 kcal/day and 23 ± 15 g protein/day were offered. Mean daily energy intake increased by 207 (95%CI 47–368, p = 0.005) kcal and protein intake by 14 (7–21, p < 0.001) g (w12 vs w1). Quality of life (QoL) increased in the subscale “care relationship” (+ 9 (3–15) points, p = 0.002, w12 vs w6). Body weight, handgrip strength, and other QoL subscales did not change.

Conclusion

Our intervention improved dietary intake and one QoL subscale in NH residents with (risk of) malnutrition. As a next step, randomized controlled trials are needed to investigate the impact of individualised interventions more comprehensively.
Curl Constraint-Preserving Reconstruction and the Guidance it Gives for Mimetic Scheme Design
Authors: Balsara Dinshaw S. , Käppeli Roger , Boscheri Walter , Dumbser Michael
Published: December 2021

Several important PDE systems, like magnetohydrodynamics and computational electrodynamics, are known to support involutions where the divergence of a vector field evolves in divergence-free or divergence constraint-preserving fashion. Recently, new classes of PDE systems have emerged for hyperelasticity, compressible multiphase flows, so-called first-order reductions of the Einstein field equations, or a novel first-order hyperbolic reformulation of Schrödinger’s equation, to name a few, where the involution in the PDE supports curl-free or curl constraint-preserving evolution of a vector field. We study the problem of curl constraint-preserving reconstruction as it pertains to the design of mimetic finite volume (FV) WENO-like schemes for PDEs that support a curl-preserving involution. (Some insights into discontinuous Galerkin (DG) schemes are also drawn, though that is not the prime focus of this paper.) This is done for two- and three-dimensional structured mesh problems where we deliver closed form expressions for the reconstruction. The importance of multidimensional Riemann solvers in facilitating the design of such schemes is also documented. In two dimensions, a von Neumann analysis of structure-preserving WENO-like schemes that mimetically satisfy the curl constraints, is also presented. It shows the tremendous value of higher order WENO-like schemes in minimizing dissipation and dispersion for this class of problems. Numerical results are also presented to show that the edge-centered curl-preserving (ECCP) schemes meet their design accuracy. This paper is the first paper that invents non-linearly hybridized curl-preserving reconstruction and integrates it with higher order Godunov philosophy. By its very design, this paper is, therefore, intended to be forward-looking and to set the stage for future work on curl involution-constrained PDEs.
New Kids on the Recycling Block: the Role of Supermarkets and Bodegas for Sustainable Consumer Behaviour in Lima
Authors: Borasino Elena , Fuhrmann-Riebel Hanna
Published: December 2021

Only 4% of total municipal solid waste in Lima is recycled. Supermarkets and bodegas are in a unique, highly relevant position for the transition towards a circular economy due to their direct influence on customers’ consumption patterns. This paper explores the role of supermarkets and bodegas for consumer recycling behaviour, looking both at already implemented practices and possibilities for the future. Based on semi-structured interviews conducted with key actors in the recycling sector in 2019 and 2020, we analyse the sector regarding its main actors and their different interests, the interactions between them and the regulatory framework, as well as specific initiatives undertaken to increase recycling. We then compare the main mechanisms through which consumer recycling behaviour can be influenced between supermarkets and bodegas based on the three categories convenience, knowledge and socio-psychological factors. Our in-depth analysis outlines the different pros and cons for each of the three categories in detail.
The interaction effect between advanced paternal age and paternal obesity is associated with the low implantation rate in couples with unexplained recurrent pregnancy loss
Authors: Li Shuo , Shen Yaqian , Zhu Yueting , Li Hongchang , Jiang Wenjie , Yan Junhao , Chen Zi-Jiang
Published: November 2021

Objective

To explore the roles of advanced paternal age (APA) and abnormal paternal weight on embryo quality and pregnancy outcomes for unexplained recurrent pregnancy loss (uRPL) couples who underwent preimplantation genetic testing for aneuploidies (PGT-A).

Methods

This study included 779 uRPL couples who underwent their first PGT-A cycles between 2014 and 2018. Male patients’ aging and nutritional status were quantified by paternal age and body mass index (BMI). Routine semen parameters and sperm DNA fragmentation index (DFI) were used to reflect the seminal quality. Blastocyst formation rate and aneuploidy rate were used to reflect the embryo quality. Cycle cancellation rate, implantation rate, pregnancy loss rate, and live birth rate were measured to evaluate the treatment efficiency from IVF. To remove the interference of maternal age, only the women younger than 38 years old were included. After univariate screening, interaction tests were performed in a generalized linear model (GLM) to further examine the effects of paternal age and BMI on each outcome indicator.

Results

In the total population (779 cycles), there were no statistical differences in aneuploidy rate, cycle cancellation rate, implantation rate, pregnancy loss rate, and live birth rate, whether stratified by paternal age or paternal BMI. Similar results occurred in the younger men (<40 y.o., 633 cycles). Conversely, among the men with advanced age (≥40 y.o., 146 cycles), there were statistical differences between the three BMI groups in four semen parameters (total sperm number, total motility, progressive motility, and total motile sperm count), implantation rate, and live birth rate. After interaction testing, the results of GLM suggested that the interaction effect between APA and paternal obesity was associated with the low implantation rate of uRPL couples.

Conclusions

For the uRPL couples seeking for PGT-A treatment, if the male patients have both advanced age and obesity, their spouses are at higher risks for embryo implantation failure.
Radiotherapy and Immunotherapy in Melanoma Brain Metastases
Authors: Anvari Amir , Sasanpour Pegah , Kheradmardi Mania Rajabzadeh
Published: December 2021

Background and objective:

Melanoma brain metastasis (MBM) generally portends a dismal prognosis. Simultaneous use of radiotherapy (RT) and immune checkpoint inhibitor (ICI) therapy demonstrated tremendous promise and emerged as the new standard. This meta-analysis was conducted to evaluate survival outcomes and toxicities of this combination in patients with MBM. Data analyses were performed using Comprehensive Meta-Analysis software (version 2) and IBM SPSS software (version 27).

Methods:

A systematic literature search of PubMed, EMBASE, and the Cochrane Library (via Wiley) was conducted using PICOS/PRISMA selection protocol and included studies to evaluate survival and safety-associated outcomes of ICI + RT for the treatment of MBM.

Results:

A total 44 studies involving 2498 patients were reviewed. The pooled effect size (ES) for overall survival (OS) to compare the ICI + RT arm and ICI alone arm (HR: 0.693 [0.526–0.913, p = .001]), and compare the ICI + RT arm and brain RT alone (HR: 0.595 [0.489–0.723, p < .001)] indicated better survival outcomes in ICI + RT versus RT alone and ICI alone arms. Comparing central nervous system toxicity in the ICI + RT arm and RT alone arm, the pooled ES Grade ≥ 3 neurologic adverse events (NAEs) risk ratio ([RR] = 1.425; 95% confidence interval [CI]: 0.485–4.183; p = .519) indicated that ICI + RT nonsignificantly increased Grade 3–4 NAEs. Comparing Grade ≥ 3 radiation necrosis in the ICI + RT arm and RT alone arm, the pooled ES RR (RR = 2.73; 95% CI: 0.59–12.59; p = .199) indicated that ICI + RT nonsignificantly increased Grade ≥ 3 radiation necrosis.

Conclusion:

Concurrent administration of RT and ICI evinced favorable OS outcomes and acceptable safety profile in MBM patients. Planned prospective trials are required to demonstrate the issue.
Initiation and feasibility of a multi-specialty minimally invasive surgical programme using a novel robotic system: A case series
Authors: Dixon Frances , Khanna Achal , Vitish-Sharma Parveen , Singh Nidhi Shandil , Nakade Kailash , Singh Anjana , Qureshi Adnan , O’Hara Richard , Keeler Barrie D.
Published: November 2021

Abstract

Introduction

There are a number of small case series examining new robotic surgical systems, but this is the first large case series assessing the feasibility of the Versius® system from CMR Surgical (1 Evolution Business Park, Cambridge, UK) in a multi-specialty setting.

Materials and methods

All patients undergoing Versius®-assisted surgery in a previously robot-naïve centre were consented for collection of data on demographics, pre-, intra-, and postoperative outcomes. Data collection was performed prospectively from the start of the robotic surgical programme.

Results

160 operations were performed over a 19-month period, including 68 colorectal, 60 gynaecology, and 32 general surgery cases. The conversion rate to open surgery was 4.4% for colorectal, and 0% for gynaecology and general surgery. Median length of stay was 6 days for colorectal, 1 day for gynaecology, and 0 days for general surgery. Other outcomes were comparable to existing literature for robotic assisted surgery.

Conclusion

The Versius® system is safe and feasible for use in a multi-specialty minimally invasive surgery programme, including colorectal, general surgical & gynaecological cases, and operative volume can be safely and easily scaled up in a district general hospital setting without prior robotic surgical experience.

Highlights
Positive Beliefs about Post-Event Processing in Social Anxiety Disorder
Authors: Lenton-Brym Ariella P. , Provost-Walker Olivia , Tsekova Virginia , McCabe Randi E. , Rowa Karen
Published: December 2021

Background: Post-event processing (PEP) is an important maintenance factor of social anxiety disorder (SAD). This study examined psychometric properties of the Positive Beliefs about Post-Event Processing Questionnaire (PB-PEPQ; Fisak & Hammond, 2013), which measures metacognitive beliefs about PEP. Method: Participants receiving treatment for SAD (n = 71) and other anxiety and related disorders (n = 266) completed self-report questionnaires at several timepoints. Results: Confirmatory factor analysis did not support the PB-PEPQ's proposed unidimensional model. Subsequent exploratory factor analysis yielded a three-factor structure consisting of engaging in PEP to (1) review negative events (Negative scale), (2) review positive events (Positive scale), and (3) better understand one's social anxiety (Understand scale). Within the SAD subsample, PB-PEPQ scales demonstrated good internal consistency (α = 0.83–0.85) and test–retest reliability (r = 0.65–0.78). Convergent and criterion validity of the PB-PEPQ Negative scale were supported. PB-PEPQ scale scores were significantly higher within the SAD group, as compared with the other groups (generalised anxiety disorder, panic disorder and agoraphobia, posttraumatic stress disorder, and obsessive-compulsive disorder), supporting the scales’ discriminative validity. Conclusion: Findings support the reliability and validity of the PB-PEPQ in a clinical sample and reveal the measure's multifactorial structure.
Epileptic Prodromes: Insights from Surveying 196 Patients and 150 Caregivers
Authors: Gagliano Laura , Bou Assi Elie , Herrera-Fortin Tamara , Lesage Frédéric , Sawan Mohamad , Nguyen Dang K.
Published: December 2021

Objective:

Uncontrolled epilepsy creates a constant source of worry for patients and puts them at a high risk of injury. Identifying recurrent “premonitory” symptoms of seizures and using them to recalibrate seizure prediction algorithms may improve prediction performances. This study aimed to investigate patients’ ability to predict oncoming seizures based on preictal symptoms.

Methods:

Through an online survey, demographics and clinical characteristics (e.g., seizure frequency, epilepsy duration, and postictal symptom duration) were collected from people with epilepsy and caregivers across Canada. Respondents were asked to answer questions regarding their ability to predict seizures through warning symptoms. A total of 196 patients and 150 caregivers were included and were separated into three groups: those who reported warning symptoms within the 5 minutes preceding a seizure, prodromes (symptoms earlier than 5 minutes before seizure), and no warning symptoms.

Results:

Overall, 12.2% of patients and 12.0% of caregivers reported predictive prodromes ranging from 5 minutes to more than 24 hours before the seizures (median of 2 hours). The most common were dizziness/vertigo (28%), mood changes (26%), and cognitive changes (21%). Statistical testing showed that respondents who reported prodromes also reported significantly longer postictal recovery periods compared to those who did not report predictive prodromes (P < 0.05).

Conclusion:

Findings suggest that patients who present predictive seizure prodromes may be characterized by longer patient-reported postictal recovery periods. Studying the correlation between seizure severity and predictability and investigating the electrical activity underlying prodromes may improve our understanding of preictal mechanisms and ability to predict seizures.
Development of On-Site Medical System for Mass-Gathering Events During TOKYO 2020: Vulnerability Analysis Using Healthcare Failure Mode and Effect Analysis
Authors: Yamamoto Ryo , Maeshima Katsuya , Asakawa Shoko , Haiden Akina , Nishida Yusho , Yamazaki Noriko , Homma Koichiro , Sasaki Junichi
Published: December 2021

At mass-gathering events of the Olympic and Paralympic Games, a well-organized, on-site medical system is essential. This study evaluated the vulnerabilities of the prehospital medical system of the TOKYO 2020 Olympic and Paralympic Games (TOKYO2020) to propose corrections that can be generalized to other mass gatherings. The healthcare failure mode and effect analysis (HFMEA) was adopted to analyze vulnerabilities of the on-site medical system proposed by the organizing committee of TOKYO2020. Processes from detecting a patient on the scene to completing transport to a hospital were analyzed. Ten processes with 47 sub-processes and 122 possible failure modes were identified. HFMEA revealed 9 failure modes as vulnerabilities: misidentification of patient, delayed immediate care at the scene, misjudgment of disposition from the on-site medical suite, and inappropriate care during transportation to hospital. Proposed corrections included surveillance to decrease blind spots, first aid brochures for spectators, and uniform protocol for health care providers at the scene. The on-site medical system amended by HFMEA seemed to work appropriately in TOKYO2020.
Meso-Cenozoic negative inversion model for the Linhe Depression of Hetao Basin, China
Authors: Yu Fusheng , Zhang Ruifeng , Yu Jiafu , Wang Yidan , Chen Shuguang , Liu Jing , Wu Chenlin , Wang Yiqun , Wang Shaochun , Wang Yuheng , Liu Yilun
Published: December 2021

The Linhe Depression is the largest tectonic unit in the Hetao Basin. The recently discovered commercial oil flow in the structural trap of wells JH2X and S5 has proved that the Meso-Cenozoic strata in the Linhe Depression have great exploration potential. Research on the kinematic model for the Mesozoic–Cenozoic Linhe Depression is important for analysing the geological conditions of hydrocarbon accumulation. In this study, field observations, seismic interpretation and scaled analogue modelling are performed. The results prove that the Linhe Depression experienced different stages of tectonic evolution, such as compressional depression (K1l), conversion from contraction to uniform subsidence (K1g), extensional rifting (E2–N2) and strike-slip deformation (Q), during the Mesozoic–Cenozoic eras. The kinematic model of negative inverted basins was first established with the early differential compression superimposed by the late extension. The seismic interpretation and analogue modelling results show that Jilantai Sag in the southern part of the Linhe Depression was subjected to compression from the Bayanwulashan fold–thrust belt on the NW side and the Helanshan fold–thrust belt on the SE side during Early Cretaceous time. Meanwhile, the Hanghou Sag in the northern part of the Linhe Depression was only compressed by the Langshan fold–thrust belt from the NW direction. The rifted structure generated by the extension from the SE direction during the Cenozoic Era resulted in the negative inversion of the pre-existing thrusts in different patterns. The intensity of negative inversion is controlled by several key factors, such as dip angle and the patterns of thrust faults, along with different basement textures. The morphological changes in the forebulge zone developed during Early Cretaceous time are responsible for the development of the segmented Central fault zones in the Hanghou Sag.
Affirmative action measures and electoral candidates’ positioning in Zambia
Authors: Wang Vibeke , Muriaas Ragnhild L. , Peters Yvette
Published: December 2021

While the increase of women in elected office has received much scholarly attention, less attention has been paid to the dynamics of resisting gender quotas in countries that fail to adopt such measures despite regional and international pressure. We develop a context-sensitive typology of affirmative action measures that includes gender quotas and funding incentives and explore determinants of electoral candidates’ positioning in the context of Zambia. Using a sequential mixed-methods approach and unique data, we examine how candidates of different gender, party affiliation, and level of electoral success position themselves when asked to choose between different options. Intriguingly, electoral success and party allegiance – whether a candidate is affiliated with a current or former government party – are more important than gender. This finding is relevant for the debate on feminist democratic representation by showing that candidates are likely to have their more radical views muted when getting into position.
Role Inversion and Its Function in the Iphigeneia at Aulis
Authors: Chant Dale
Published: December 2021

In the Iphigeneia at Aulis role and role inversion are paramount concerns. Indeed it could be contended that in this play we find Euripides' clearest and best defined account of human (and divine) variability. Agamemnon, Menelaos, Achilleus, Iphigeneia, and even, in the final analysis, Artemis, all take positions and attitudes diametrically opposed to those initially adopted. Moreover, the basic thrust behind these movements in position and attitude is the same for each of these characters. All are concerned, in one way or another, with the saving or destruction of Iphigeneia, a situation which most emphatically includes Iphigeneia herself. For on the one hand she wildly supplicates to be saved, while on the other she gladly offers her body to the blade. In addition, Iphigeneia plays a crucial role in greater destructions. If she is destroyed by Agamemnon's and the army's actions, then Greece is destroyed in turn by her (Agamemnon's and the Greeks' final triumph is a ‘Pyrrhic’ victory at best), a situation made all the more ironic by her affected stance of saviour to the fatherland. In Iphigeneia's case, however, the discrepancy between intention and the consequences of action is innocent enough. The play gives no hint that she is at all aware of the irony implicit in her actions. But such lack of awareness is not postulated with regard to Agamemnon, Menelaos and Achilleus. The duplicities and hypocrisies of these three have been the subject of much analysis, and it is at least a critical commonplace to observe that they are characterised in a way more reminiscent of the sour end of everyday life than of the due proprieties associated with heroic, or Homeric, behaviour.
Different by Culture
Authors: Doebler Marie-Kristin
Published: December 2021

Abstract. This article suggests that the term “culture” can explain the heterogeneity of age(ing) in nursing homes as well as (dis-)similarities opposed to organizational parameters (e.g., size, location, ownership). It introduces an analytical tool for the systematic analysis of culture which encompasses 15 thematic dimensions grouping as conceptualizations of age(ing), social relationships, and care. Two nursing homes from an explorative project in Bavarian nursing homes are used for illustrating the tool’s possible applications: systematic description, explanation, and comparisons of locally effective cultures; determining ambivalences’ manifestations and sources. The article ends with a discussion of underlying implications of the findings for theory and praxis and the benefits and weaknesses of this study, connected with the hope to broaden the perception of nursing homes which are more than organizations designed to house older people safely; they are also culturally shaped places of social life.
Geochemical Profiles Across the Listvenite‐Metamorphic Transition in the Basal Megathrust of the Semail Ophiolite: Results From Drilling at OmanDP Hole BT1B
Authors: Godard M. , Carter E. J. , Decrausaz T. , Lafay R. , Bennett E. , Kourim F. , de Obeso J.‐C. , Michibayashi K. , Harris M. , Coggon J. A. , Teagle D. A. H. , Kelemen P. B. ,   the Oman Drilling Project Phase 1 Science Party
Published: December 2021

The transition from the Semail ophiolite mantle to the underlying metamorphic sole was drilled at ICDP OmanDP Hole BT1B. We analyzed the bulk major, volatile and trace element compositions of the mantle‐derived listvenite series and metamorphic rocks, with the aim to constrain chemical transfers associated with peridotite carbonation along the ophiolite basal thrust. The listvenite series comprise variously carbonated serpentinites and (fuchsite‐bearing) listvenites. They have high CO2 (up to 43 wt.%) and variable H2O (0–12 wt.%). Yet, they have compositions close to that of the basal banded peridotites for most major and lithophile trace elements, with fuchsite‐bearing listvenites overlapping in composition with amphibole‐bearing basal lherzolites (e.g., Al2O3 = 0.1–2.2 wt.%; Yb = 0.05–1 x CI‐chondrite). The protolith of the listvenite series was likely similar in structure and composition to serpentinized banded peridotites which immediately overlie the metamorphic sole elsewhere in Oman. The listvenite series are enriched in fluid mobile elements (FME) compared to Semail peridotites (up to ∼103–104 x Primitive Mantle), with concentrations similar to the underthrusted metabasalts and/or metasediments for Cs, Sr and Ca and sometimes even higher for Pb, Li, As, and Sb (e.g., Li up to 130 μg/g; As up to 170 μg/g). We also observe a decoupling between Sr‐Ca enrichments and other FME, indicating interactions with several batches of deep CO2‐rich fluids transported along the basal thrust. These results suggest that peridotite carbonation could represent one of the major trap‐and‐release mechanisms for carbon, water and FME along convergent margins.
Contrasting Effects of Indian Ocean Basin and Dipole Modes on the Stratosphere
Authors: Huang Rui , Tian Wenshou , Qie Kai , Xie Fei , Zhang Shiyan , Tian Hongying , Luo Jiali
Published: December 2021

The stratospheric impact of the sea surface temperature (SST) variability in the Indian Ocean has attracted extensive attention. Recent warming of the tropical Indian Ocean is characterized by increases in both the magnitude and zonal gradient, which is related to the variability in the positive phase of the Indian Ocean basin mode (IOBM) and Indian Ocean dipole mode (IOD). Yet, previous studies mainly focused on the stratospheric impact of the IOBM. Using the Whole Atmosphere Community Climate Model (version 4), this study explores the impact of positive IOD events on the stratosphere and compares it with the IOBM. Results show that the IOBM (IOD) serves to dry (moisten) the tropical lower stratosphere on the annual average. The moistening (drying) of the lower stratosphere in response to IOBM occurs mainly in winter and spring (autumn), while the IOD exerts a moistening effect in winter. Both modes can enhance the northern stratospheric polar vortex, and the effect of IOD is close to that of IOBM, although SST anomalies associated with the IOD are smaller. This implies that the Indian Ocean SST gradient exerts a greater influence on the Northern Hemisphere stratosphere than does the Indian Ocean SST magnitude. Moreover, both modes weaken the southern stratospheric polar vortex, but the effect of IOD is much smaller since its impact on stationary waves is weak. Contrary to the Northern Hemisphere stratosphere, the Southern Hemisphere stratosphere is more sensitive to the Indian Ocean SST magnitude than to the SST gradient.
Relativistic Runaway Electron Avalanches Within Complex Thunderstorm Electric Field Structures
Authors: Stadnichuk E. , Svechnikova E. , Nozik A. , Zemlianskaya D. , Khamitov T. , Zelenyy M. , Dolgonosov M.
Published: December 2021

Relativistic runaway electron avalanches (RREAs) are generally accepted as a source of thunderstorms gamma ray radiation. Avalanches can multiply in the electric field via the relativistic feedback mechanism based on processes with gamma rays and positrons. This study shows that a non‐uniform electric field geometry can lead to the new RREAs multiplication mechanism—“reactor feedback,” due to the exchange of high‐energy particles between different accelerating regions within a thundercloud. A new method for the numerical simulation of RREA dynamics within heterogeneous electric field structures is proposed. Under the assumption that reactor feedback can produce a terrestrial gamma ray flash (TGF), necessary conditions for TGF occurrence in the system with the reactor feedback are derived using the developed analytical description and the numerical simulation. Observable properties of TGFs influenced by the proposed mechanism are discussed.
HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer
Authors: Xu Jie , Meng Qingtao , Sun Hao , Zhang Xinwei , Yun Jun , Li Bin , Wu Shenshen , Li Xiaobo , Yang Hongbao , Zhu Haitao , Aschner Michael , Relucenti Michela , Familiari Giuseppe , Chen Rui
Published: November 2021

Chimeric antigen receptor (CAR) - T cell therapy is a new class of cellular immunotherapies, which has made great achievements in the treatment of malignant tumors. Despite improvements in colorectal cancer (CRC) therapy, treatment of many patients fails because of metastasis and recurrence. The human epidermal growth factor receptor 2 (HER2) is a substantiated target for CAR-T therapy, and has been reported recently to be over-expressed in CRC, which may provide a potential therapeutic target for CRC treatment. Herein, HER2 was a promising target of metastatic colorectal cancer (mCRC) in CAR-T therapy as assessed by flow cytometry and tissue microarray (TMA) with 9-year survival follow-up data. Furthermore, HER2-specific CAR-T cells exhibited strong cytotoxicity and cytokine-secreting ability against CRC cells in vitro. Moreover, through the tumor-bearing model of the NOD-Prkdcem26cd52Il2rgem26Cd22/Nju (NCG) mice, HER2 CAR-T cells showed signs of effectively preventing CRC progression in three different xenograft models. Notably, HER2 CAR-T cells displayed greater aggressiveness in HER2+ CRC in the patient-derived tumor xenograft (PDX) models and had potent immunotherapeutic capacity for mCRC in the metastatic xenograft mouse models. In conclusion, our studies provide scientific evidence that HER2 CAR-T cells represent an emerging immunotherapy for the treatment of mCRC.
MORC protein family-related signature within human disease and cancer
Authors: Wang Huan , Zhang Ling , Luo Qiuhua , Liu Jia , Wang Guiling
Published: November 2021

The microrchidia (MORC) family of proteins is a highly conserved nuclear protein superfamily, whose members contain common domain structures (GHKL-ATPase, CW-type zinc finger and coiled-coil domain) yet exhibit diverse biological functions. Despite the advancing research in previous decades, much of which focuses on their role as epigenetic regulators and in chromatin remodeling, relatively little is known about the role of MORCs in tumorigenesis and pathogenesis. MORCs were first identified as epigenetic regulators and chromatin remodelers in germ cell development. Currently, MORCs are regarded as disease genes that are involved in various human disorders and oncogenes in cancer progression and are expected to be the important biomarkers for diagnosis and treatment. A new paradigm of expanded MORC family function has raised questions regarding the regulation of MORCs and their biological role at the subcellular level. Here, we systematically review the progress of researching MORC members with respect to their domain architectures, diverse biological functions, and distribution characteristics and discuss the emerging roles of the aberrant expression or mutation of MORC family members in human disorders and cancer development. Furthermore, the illustration of related mechanisms of the MORC family has made MORCs promising targets for developing diagnostic tools and therapeutic treatments for human diseases, including cancers.
Organelle genome assembly uncovers the dynamic genome reorganization and cytoplasmic male sterility associated genes in tomato
Authors: Kuwabara Kosuke , Harada Issei , Matsuzawa Yuma , Ariizumi Tohru , Shirasawa Kenta
Published: December 2021

To identify cytoplasmic male sterility (CMS)-associated genes in tomato, we determined the genome sequences of mitochondria and chloroplasts in three CMS tomato lines derived from independent asymmetric cell fusions, their nuclear and cytoplasmic donors, and male fertile weedy cultivated tomato and wild relatives. The structures of the CMS mitochondrial genomes were highly divergent from those of the nuclear and cytoplasmic donors, and genes of the donors were mixed up in these genomes. On the other hand, the structures of CMS chloroplast genomes were moderately conserved across the donors, but CMS chloroplast genes were unexpectedly likely derived from the nuclear donors. Comparative analysis of the structures and contents of organelle genes and transcriptome analysis identified three genes that were uniquely present in the CMS lines, but not in the donor or fertile lines. RNA-sequencing analysis indicated that these three genes transcriptionally expressed in anther, and identified different RNA editing levels in one gene, orf265, that was partially similar to ATP synthase subunit 8, between fertile and sterile lines. The orf265 was a highly potential candidate for CMS-associated gene. This study suggests that organelle reorganization mechanisms after cell fusion events differ between mitochondria and chloroplasts, and provides insight into the development of new F1 hybrid breeding programs employing the CMS system in tomato.
SISTER OF TM3 activates FRUITFULL1 to regulate inflorescence branching in tomato
Authors: Wang Xiaotian , Liu Zhiqiang , Sun Shuai , Wu Jianxin , Li Ren , Wang Haijing , Cui Xia
Published: December 2021

Selection for favorable inflorescence architecture to improve yield is one of the crucial targets in crop breeding. Different tomato varieties require distinct inflorescence-branching structures to enhance productivity. While a few important genes for tomato inflorescence-branching development have been identified, the regulatory mechanism underlying inflorescence branching is still unclear. Here, we confirmed that SISTER OF TM3 (STM3), a homolog of Arabidopsis SOC1, is a major positive regulatory factor of tomato inflorescence architecture by map-based cloning. High expression levels of STM3 underlie the highly inflorescence-branching phenotype in ST024. STM3 is expressed in both vegetative and reproductive meristematic tissues and in leaf primordia and leaves, indicative of its function in flowering time and inflorescence-branching development. Transcriptome analysis shows that several floral development-related genes are affected by STM3 mutation. Among them, FRUITFULL1 (FUL1) is downregulated in stm3cr mutants, and its promoter is bound by STM3 by ChIP-qPCR analysis. EMSA and dual-luciferase reporter assays further confirmed that STM3 could directly bind the promoter region to activate FUL1 expression. Mutation of FUL1 could partially restore inflorescence-branching phenotypes caused by high STM3 expression in ST024. Our findings provide insights into the molecular and genetic mechanisms underlying inflorescence development in tomato.
Overexpression of PvWOX3a in switchgrass promotes stem development and increases plant height
Authors: Yang Ruijuan , Wu Zhenying , Bai Chen , Sun Zhichao , Wang Mengqi , Huo Yuzhu , Zhang Hailing , Wang Yamei , Zhou Huapeng , Dai Shaojun , Liu Wenwen , Fu Chunxiang
Published: December 2021

Switchgrass (Panicum virgatum L.) is an important perennial, noninvasive, tall ornamental grass that adds color and texture to gardens and landscapes. Moreover, switchgrass has been considered a forage and bioenergy crop because of its vigorous growth, low-input requirements, and broad geography. Here, we identified PvWOX3a from switchgrass, which encodes a WUSCHEL-related homeobox transcription factor. Transgenic overexpression of PvWOX3a in switchgrass increased stem length, internode diameter, and leaf blade length and width, all of which contributed to a 95% average increase in dry weight biomass compared with control plants. Yeast one-hybrid and transient dual-luciferase assays showed that PvWOX3a can repress the expression of gibberellin 2-oxidase and cytokinin oxidase/dehydrogenase through apparently direct interaction with their promoter sequences. These results suggested that overexpression of PvWOX3a could increase gibberellin and cytokinin levels in transgenic switchgrass plants, which promotes cell division, elongation, and vascular bundle development. We also overexpressed PvWOX3a in a transgenic miR156-overexpressing switchgrass line that characteristically exhibited more tillers, thinner internodes, and narrower leaf blades. Double transgenic switchgrass plants displayed significant increases in internode length and diameter, leaf blade width, and plant height but retained a tiller number comparable to that of plants expressing miR156 alone. Ultimately, the double transgenic switchgrass plants produced 174% more dry-weight biomass and 162% more solubilized sugars on average than control plants. These findings indicated that PvWOX3a is a viable potential genetic target for engineering improved shoot architecture and biomass yield of horticulture, fodder, and biofuel crops.