bluuebunny/crossref_metadata_2025 huggingface dataset:
Teaching work, gender relations and illness
Authors: Silva Érika Carvalho , Araújo Marcos Vinícius Ribeiro de , Oliveira Elaine Cristina de
Published: December 2022

In addition to the adversities that the mode of production and the work process affect teachers' illness, the social marker of gender puts women at a disadvantage and ends up intensifying illness. The objective of this research was to analyze the impact of the gender social marker on the health-disease process related to the work of public school teachers in the city of Salvador. As for the method, it is an empirical research, with a qualitative approach, based on the socio-historical perspective. We used direct observations and semi-structured interviews as data production instruments. Three teachers participated in the study. Data were transcribed and systematized into semantic categories according to the content analysis technique. The results showed that the teachers perceive connections between the illness and work, identify the impacts of the precariousness of the profession and the teaching work process, as well as signaling important inequalities in the sexual division of unpaid domestic work. As conclusions, the research indicates that gender inequalities are intertwined with the illness, and also points out that the routine marked by the exhaustion of professional practice and the overload of unpaid domestic work are obstacles for teachers to seek coping strategies for the illness. work related.
Examining Measurement Invariance in Bayesian Item Response Theory Models: A Simulation Study
Authors: AYVALLI Merve , KELECİOĞLU Hülya
Published: December 2022

The aim of the study is to determine a measurement invariance cut-off point based on item parameter differences in Bayesian Item Response Theory Models. Within this scope, the Bayes factor is estimated for testing measurement invariance. For this purpose, a simulation study is conducted. The data were generated in the R software for each simulation condition under the one-parameter logistic model for 10 binary (1-0 scored) items. The invariance test was performed for various group sizes (n=500, 1000, 1500 and 2000) and difficulty parameters (dk=0, dk=0.1, dk=0.3, dk=0.5 and dk=0.7). The Bayesian analyzes were performed on the WINBUGS using the codes written in the R. A Bayes factor that provides evidence for measurement invariance was calculated depending on the parameter differences. The Savage–Dickey density ratio, one of the MCMC sampling schemas, was used to calculate the Bayes factor. As a result, if the item parameter difference is dk=0.3 and group sizes are 1500 or larger, the measurement invariance cannot be achieved. However, for small sample sizes (n=1000 or less) measurement invariance interpretation should be done carefully. When the dk=0.5, there are invariant items only in n=500. According to Bayes factor test results, evidence has been produced when dk=0.7 that measurement invariance cannot be achieved.
Android-based Application of Production Cost Calculation of Food and Beverage of the MSME
Authors: Ayunina Ainuna Qurrata , Sumarno Sumarno
Published: December 2022

Determination of the cost of production is important for a product, many businesses determine the selling price that is not in accordance with the production cost that has been issued. Therefore, businesses have a desire to use a technology that is fast and appropriate to determine the cost of production. The purpose of making this application is to facilitate the process of determining the profit and selling price of an appropriate product based on the cost of production. The method used to calculate the cost of production is the full costing method. The app was created using the Kodular app inventor. With the making of this application can make it easier for MSME actors who have food or beverage products to calculate the basic price of production.
2021 Guided Wave Inspection of California Department of Water Resources Tainter Gate Post-Tensioned Trunnion Anchor Rods: Oroville Dam
Authors: Ray Jason D. , Thurmer Clayton R.
Published: December 2022

The Engineering and Test Branch within the Division of Operations and Maintenance of the California Department of Water Resources (DWR) and U.S. Army Corps of Engineers (USACE), Sacramento District, tasked the Sensor Integration Branch (SIB) at the Engineer Research and Development Center (ERDC) to perform nondestructive testing (NDT) on the trunnion anchor rods at Oroville Dam through the use of ultrasonic guided waves. This is the fourth year of this NDT. The results of the testing are presented along with qualitative analysis in determining whether a rod is intact or compromised. Analysis is based upon the expected results from other rods at the site, knowledge of rod response at other sites, data gathered from the trunnion rod research test bed at ERDC, and comparison to the previous year’s effort.
Analisis Kepuasan Wisatawan Terhadap Desa Wisata Halal dan Kreatif (Studi Wisata Puncak Ratu Desa Tebul Barat Kecamatan Pegantenan Kabupaten Pamekasan)
Authors: Faturrohman Ryas Tri , Kurriwati Nirma
Published: December 2022

The purpose of this research is to find out and describe the satisfaction of Halal Tourism and Puncak Ratu Tourism Creative which is spread in the community or visitors in the development of Wsiata in Pamekasan Madura. This research was conducted using a qualitative research method with a case study approach. The sampling technique of this research is field research with the sampling technique used is accidental sampling. (1). In the perception indicator of facilities and infrastructure, there are several items that have not been maximized, namely, physical condition, cleanliness condition and satisfaction in use. (2) Perception indicators on tourism infrastructure have points that according to some informants have not been met, namely communication networks and waste disposal systems. Several informants also said they were satisfied. (3) Activity comfort indicators have points according to some informants that have not been fulfilled such as services, but other informants also said they were satisfied. (4) Satisfaction indicators for tourism activities according to some informants have points that have not been met, such as prayer facilities, but some informants also said they were satisfied with these indicators. Visitors stated that they were quite satisfied with all of the items offered on the tour, although there were some visitors who stated that they did not enjoy the Puncak Ratu Tour optimally. This does not prevent tourists from enjoying the panorama presented by Puncak Ratu Tourism.
MEDIATIZATION OF NDOKWA MASQUERADE PERFORMANCES: THE AESTHETIC DYNAMICS OF AN AFRICAN INDIGENOUS CARNIVAL
Authors: S. Omoera Osakue , Epochi-Olise Ruth Etuwe
Published: December 2022

This article examines the mediatization of the aesthetic dynamics or dimensions in the masquerade performances of the Ndokwa people in Delta State, Nigeria. Masquerade performances and carnivals are spectacular indigenous theatrical activities or forms that involve the impersonation of fictive characters by costumed performers in Nigeria and across Africa. These art forms share similar elements that make them culturally significant in terms of creativity and social commentary. The Ndokwa masquerade performances during festive celebrations have been on for over two decades but have virtually not been given the deserved publicity to project them as fine tourist events. Deploying Etop Akwang’s “Medialization” model, this study uses historical-analytic, key informant interview (KII) and direct observation to consider the uniqueness of the Ndokwa masquerade performance.  It holds that the masquerade performance is a valuable cultural product that combines the characteristics of carnivals and celebrations of fluid cultural exchange that appear to have led to hybridized cultural performances amongst the people. It highlights some of the aesthetic dimensions of the Ndokwa masquerades and how they could be made more culturally viable and economically appealing through the use of new media outlets. This article, therefore, advocates for the use of social media as a trendy form of mediatization or media production to give visibility to Ndokwa masquerade performances in the global cultural space.
Phantom Shares: una aproximación a su concepto
Authors: Belloni Román Adriano
Published: December 2022

Este artículo trata acerca de las phantom shares, uno de los planes de retribución más frecuentes en el ámbito de las startups. A través de la enumeración de sus principales características y una breve comparativa con otros instrumentos análogos, el objetivo principal es el de realizar un análisis general acerca de las mismas.
EL MARCO LEGAL DE LOS SITIOS DE RESEÑAS Y DE LAS RESEÑAS EN LÍNEA DE CONSUMIDORES
Authors: Maldonado Molina Fco. Javier
Published: December 2022

En este trabajo se analiza el marco legal aplicable a las reseñas en línea y a las reseñas de los consumidores, sobre el que hay escasas disposiciones específicas, debiendo acudirse a disposiciones de carácter general. Además de repasar los principales propuestas de Buenas Prácticas que existen, se examina el régimen sobre prácticas comerciales desleales contenido en la Directiva (UE) 2019/2161, así como otro de interés disperso en diferentes disposiciones, como la legislación sobre comercio electrónico (LSSI); sobre relaciones entre los usuarios profesionales y los servicios de intermediación en línea (Reglamento UE 2019/1150); sobre garantía de los derechos digitales (LOPD-GDD); sobre derecho al honor (LO 1/1982); y finalmente se exponen otros posibles actos de competencia desleal en relación a las reseñas.
Localization of protoporphyrin IX in glioma patients with paired stimulated Raman histology and two-photon excitation fluorescence microscopy
Authors: Nasir-Moin Mustafa , Wadiura Lisa , Juros Devin , Movahed-Ezazi Misha , Lee Matthew , Weiss Hannah , Müther Michael , Alber Daniel , Ratna Sujay , Fang Camila , Suero-Molina Eric , Hellwig Sönke , Stummer Walter , Rössler Karl , Hainfellner Johannes , Widhalm Georg , Kiesel Barbara , Reichert David , Mischkulnig Mario , Jain Rajan , Smith Andrew , Straehle Jakob , Neidert Nicolas , Schnell Oliver , Beck Jürgen , Trautman Jay , Pastore Steve , Pacione Donato , Placantonakis Dimitris , Oermann Eric , Golfinos John , Hollon Todd , Snuderl Matija , Freudiger Christian , Heiland Dieter Henrik , Orringer Daniel
Published: December 2022

Fluorescence guidance is widely utilized to improve the precision of cancer surgery. 5-aminolevulinic acid, the most widely used fluorophore in glioma surgery, is thought to cause selective accumulation of fluorescent protoporphyrin IX (PpIX) in tumor cells. 5-aminolevulinic acid is highly specific for densely tumor-infiltrated tissue but less effective for visualizing the tumor periphery. To improve clinical detection of PpIX, we developed a microscope to perform paired stimulated Raman histology and two-photon excitation fluorescence microscopy (TPEF) and validated it in 175 fresh tumor specimens from 75 high-grade glioma patients across three institutions. Here, we demonstrate that intracellular PpIX accumulation occurs most prominently in histiocytic, rather than neoplastic, appearing cells. Spatially resolved metabolomics, transcriptomics and RNA sequencing revealed that PPIX is most avidly concentrated in tumor associated macrophages. There was no correlation between the degree of tissue cellularity and PpIX concentration across all imaged specimens (R=-0.21). Our findings encourage reconsideration of the existing theory of 5-ALA-induced glioma cell fluorescence and demonstrate how 5-ALA and TPEF imaging can provide a window into the immune microenvironment of human gliomas.
Investigating the role of a putative endolysin-like candidate effector protein in Verticillium longisporum virulence
Authors: Rafiei Vahideh , Najafi Yasaman , Velez Heriberto , Tzelepis Georgios
Published: December 2022

Verticillium is a genus of ascomycete fungi that encompasses several plant pathogenic species, and cause severe annual yield losses on many economically important crops worldwide. One of the most important species in this genus, is V. longisporum, which causes disease mainly on plants in the Brassicaceae family. Genome analysis of V. longisporum strain VL1 revealed a number of candidate effector genes that may be associated with fungal virulence. One of these candidate effector-genes encodes a putative endolysin-like protein. Endolysins are hydrolytic enzymes that are secreted by bacteriophages and recently, they have been identified in fungal genomes as well. In this study, the potential role of this gene has been investigated in V. longisporum. Our data showed that this gene was highly induced in the fungus during Brassica napus infection and its overexpression significantly increased V. longisporum virulence, indicating an involvement in the fungal infection process.
DMPA-HHO: A Hybrid MPA-HHO optimizer with Dynamic Opposite Learning
Authors: Su Shoubao , Xu Liukai , Wang Chishe , He Chao
Published: December 2022

A new hybrid algorithm is proposed by incorporating Harris Hawks Optimization with Marine Predators algorithm and dynamic Opposition-based learning, namely DMPA-HHO. In the algorithm, the problem is addressed that Harris Hawks Optimization (HHO) tends to fall into local optima and low accuracy of the solution. Dynamic Opposite Learning (DOL) improves the swarm diversity and swarm quality, and enhances the global search capability and search accuracy. HHO and the Marine Predators Algorithm (MPA) are blended to enhance the progressive rapid dives of the Harris hawk flock, effectively improving the algorithm's exploitation capabilities. DMPA-HHO uses the FADs’ effect of the MPA to increase the possibility of individuals escaping from the local optimum solution when the search falls into the local optimal solution. Compared with others on several benchmark functions, the DMPA-HHO algorithm has a better search accuracy and a stronger ability to avoid trapping in local optima.
Characteristics and Obstetrical Outcomes of Post-Rape Pregnancies Among Adolescent Girls in Post Conflict Context in Eastern Dr Congo.
Authors: Kalunga Kiminyi , Olivier Nyakio Ngeleza , Maroyi Raha , Ilunga-Mbaya Eloge , Julien Bwama , Luc Kalala Kanyinda , Mukwege Denis
Published: December 2022

Introduction: In conflicts such as the Democratic Republic of Congo, sexual violence is systematically perpetrated against children and adolescent girls. Unwanted pregnancy is one of the complications with a myriad of consequences for the victim, the newborn, and society. This study aims to draw up characteristics and obstetrical outcomes of post-rape pregnancies of victims under 18 years old treated at Panzi General Referral Hospital (PGRH) in Eastern DR Congo. Methods: A cohort study was conducted at PGRH over two years (June 2020 to June 2022). This study included 140 adolescent girls who became pregnant post sexual assault. They were followed from confirmation of pregnancy to delivery. Sociodemographic, psycho-affective and clinical parameters were recorded and analyzed using XLSTAT 2014 software. Results: 76.4% came from rural areas, with a median age of 16 [13–17]. Pregnancy was continued in 50.7% and terminated in 20%. The victims were casual acquaintances of the perpetrators in 33.6% and unknown in 26.4%. 57. 9% attended regular antenatal consultations. 74.3% had an individual birth plan/preparation for labor, with the primary route of delivery being vaginal (69.3%). The frequency of caesarean sections was 30.7%. Some psychological symptoms were identified during labor in 52.9% like agitation (10.7%) and hypersensitivity (8.6%). Conclusion: Pregnancy post rape is a public health problem affecting adolescents between 13 and 17 years of age. These pregnancies require closer follow-up with multi-disciplinary shared care, including psychology, obstetrics, and community input, to improve mother and newborn antenatal, intrapartum, and postpartum outcomes. In addition, long-term psychological sequelae of these pregnancies can be mitigated through supportive care in this high-risk period.
Association of multi-heavy metals exposure and lung function in a typical rural population of Northwest China
Authors: Zheng Ling , Yu Yunhui , Tian Xiaoyu , He Li , Shan Xiaobing , Niu Jingping , Yan Jun , Luo Bin
Published: December 2022

Background: Heavy metal exposure is associated with decreased lung function, but the relationship between metals co-exposure and lung function in rural areas of northwest China remains unclear. Therefore, the purpose of this study is to explore the effects of single or co-exposure of heavy metals on lung function in a rural cohort of northwest China.
Methods: All participants were recruited from the Dongdagou-Xinglong (DDG-XL) rural cohort of Gansu province. Urine levels of 10 common heavy metals were detected, including cobalt (Co), nickel (Ni), molybdenum (Mo), cadmium (Cd), stibium (Sb), copper (Cu), zinc (Zn), mercury (Hg), lead (Pb) and manganese (Mn). The lung function was detected by measuring percentages of predicted forced vital capacity (FVC%) and forced expiratory volume in one second (FEV1%) as well as the ratio of FEV1/FVC. We also analyzed the association between heavy metals and pulmonary ventilation dysfunction (PVD). Restricted cubic spline, logistic regression, linear regression and Bayesian kernel machine regression (BKMR) were used to analyze the relationship between heavy metals exposure and lung function.
Results: Finally, a total of 382 participants were included in this study with the average age of 56.69 ± 7.32 years, and 82.46% of them used solid fuels for heating and cooking. Logistic regression analysis showed that the higher concentration of Hg, Mn, Sb and lower Mo may be risk factors for PVD. We found that FEV1% and FVC% were negatively correlated with Sb, Hg, Mn, but positively correlated with Mo. Through BKMR model, we found the lung function decreased with the increase of heavy metals concentration. In addition, Hg and Mn made an enormous contribution to the decline of lung function. In subgroup analysis showed that the males, the people with BMI ≥ 24kg/m2 and used solid fuels showed a higher risk of PVD when exposed to Co, Zn and Hg.
Conclusions: Our results suggested that the heavy metals exposure were associated with impairment of lung function regardless of single exposure or co-exposure, particularly for Hg and Mn.
CT with clinical scoring to differentiate phytobezoar from feces in children small bowel obstruction
Authors: Wang Ning , Lin Xiaodong , Zhang Shanshan , Shen Wei , Wu Xuedong
Published: December 2022

Background: Identification of phytobezoar in childhood small bowel obstruction (SBO) characterized by small-bowel feces sign (SBFS) is still challenging. The aim of our study was to assess the diagnostic performance of quantitative CT analysis combined with the Acute General Emergency Surgical Severity-Small Bowel Obstruction (AGESS-SBO) scoring system in determining phytobezoar-related SBO.
Methods: Sixteen phytobezoar-related SBO were regarded as phytobezoar group and the other 19 SBFS-positive SBO was regarded as control group. Demographic data, clinical presentation, and laboratory and CT findings were collected and analyzed. Each patient’s AGESS-SBO score was determined according to the individual medical record. Multivariate logistic regression analyses were used to identify significant variables associated with phytobezoar-related SBO. Diagnostic performance of key variables was assessed using receiver operating characteristic (ROC) curve analysis.
Results: Compared to control group, phytobezoar group showed a significantly shorter debris maximal length (3.0 ± 0.5 cm vs. 3.5 ± 0.7 cm, P<0.05), stronger attenuation (12.6 ± 5.9 HU vs. 8.2 ± 4.0 HU, P <0.05) in CT,and higher AGESS-SBO score (4.5 [interquartile (IQR): 4–5]) vs. (2 [IQR: 1–4]). With the combination of debris attenuation (with cut-off of >9.0 HU) and AGESS-SBO score (with cut-off of >3 points), the positive predictive value (PPV) and negative predictive value (NPV) to diagnose phytobezoar-related SBO were 80 % (12/15) and 84 % (16/19), respectively.
Conclusions:The diagnostic method of integrating quantitative CT analysis and the AGESS-SBO scoring system can improve the identification accuracy of phytobezoar in SBFS-positive childhood SBO.
Performance of serum soluble interleukin-2 receptor as a diagnostic marker for lymphoma in patients with fever
Authors: Kanda Naoki , Yamaguchi Ryota , Yamamoto Yu , Matsumura Masami , Hatakeyama Shuji
Published: December 2022

There have been few reports on the diagnostic performance of soluble interleukin-2 receptor (sIL-2R) for lymphoma. A cross-sectional study was conducted at an university hospital. All patients who were admitted to the Division of General Internal Medicine and underwent serum sIL-2R testing were included. Patients were divided into two groups based on the presence of fever (≥ 38.0oC). Among 602 patients, 421 had fever and 80 were diagnosed with lymphoma (52 of the 80 were in the febrile group). In all patients, the area under the receiver operating characteristic curve (AUROC) of sIL-2R for the diagnosis of lymphoma was 0.82 (95% confidence interval [CI], 0.76–0.87). The AUROC was significantly higher in the febrile group (0.88; 95% CI, 0.83–0.94) than in the afebrile group (0.75; 95% CI, 0.65–0.85). In the febrile group, the sensitivity and specificity were 82.7% and 83.5%, respectively, with an optimal cutoff value of 3,250 U/mL. In the afebrile group, they were 89.3% and 55.6%, respectively, with a value of 868 U/mL. Serum sIL-2R showed high performance as an adjunctive diagnostic marker for lymphoma, particularly among febrile patients. Different cutoff values should be used for patients with and without fever to maximize the diagnostic performance.
Spatial helicity response metric to quantify particle size and turbidity of heterogeneous media through circular polarization imaging
Authors: SINGH MICHAEL D. , VITKIN I. ALEX
Published: December 2022

Backscattered circularly polarized light from turbid media consists of helicity-flipped and helicity-preserved photon sub-populations (i.e., photons of perpendicular and parallel circular handedness). Their intensities and spatial distributions are found to be acutely sensitive to average scatterer size and modestly sensitive to the scattering coefficient (medium turbidity) through an interplay of single and multiple scattering effects. Using a highly sensitive intensified-CCD camera, helicity-based images of backscattered light are captured, which, with the aid of corroborating Monte Carlo simulation images and statistics, enable (1) investigation of subsurface photonic pathways and (2) development of the novel ‘spatial helicity response’ metric to quantify average scatterer size and turbidity of tissue-like samples. An exciting potential application of this work is noninvasive early cancer detection since malignant tissues exhibit alterations in scatterer size (larger nuclei) and turbidity (increased cell density).
Mapping the evidence on the Effectiveness of decentralizing HIV and TB health care services in Africa among HIV/TB patients: A systematic scoping review protocol
Authors: Msibi Zethu Sandrah , Mahomed Ozayr
Published: December 2022

Background
Antiretroviral therapy decentralization has been implemented to scale up access to treatment and improve the outcomes for patients with Human Immune-Deficiency Virus (HIV). HIV-associated tuberculosis is still a major public health concern despite the improved antiretroviral coverage.,. The aim of this scoping review is to map evidence on the feasibility of decentralization of HIV and TB health care services to improve client outcomes.
Methods
A structured literature search on the topic will be conducted in relevant bibliographic databases. The Arksey and O’Malley scoping review methodology will be used to undertake the review. PubMed, Scopus, Web of Science, EBSCOhost, and ProQuest One Academic will be searched using the following key words: “HIV and TB service decentralization” in for manuscripts published between 2017 and 2021 with title and abstract screening and full text review. Screening and extraction will be performed independently by two authors using EndNote X9 and Rayyan software. The data will be extracted using Microsoft Excel. Using a data charting form, data will be sifted and organized by key categories and themes.
Discussion
The scoping review will establish the literature on effectiveness of the decentralization models of HIV/TB care. As an anticipation, the scoping review will identify gaps for synthesis on decentralization of HIV/TB care to primary health care which may not be currently known. This review shall display different decentralization approaches and concepts that are currently available.
Systematic review registration
On September 17, 2022, we registered our protocol with the Open Science Framework (OSF) platform’s registries (registration link: https://osf.io/ht8wr).
Global competency impact of sustained remote international engagement for students
Authors: Kelly Tracy , Bekele Abebe , Kapadia Sonja G , Jassal Simrat K , Ineza Darlene , Uwizeyimana Theogene , Clarke Olivia , Flickinger Tabor E , Dillingham Rebecca , Durieux Marcel E
Published: December 2022

Background: To provide just equity in academic exchange, as well as to reduce prohibitive travel cost and address environmental concerns, the past paradigm of international student exchange has fundamentally shifted from one directional travel to mutually beneficial bidirectional remote communication between students all over the globe. Current analysis aims to quantify cultural competency and evaluate academic outcomes.
Methods: Sixty students half from the US and half from Rwanda grouped in teams of 4 engaged in a nine-month project-focused relationship. Cultural competency was evaluated prior to project initiation and six months after completion of the project. Student perspective of project development was analyzed weekly and final academic outcome was evaluated.
Results: Change in cultural competency was not significant; however, students did identify satisfaction in team interaction and academic outcomes were achieved.
Conclusion: A single remote exchange between students in two countries may not be transformative but it can provide cultural enrichment and successful academic project outcome and may serve to enhance cultural curiosity.
Classification of Health care Products using Hybrid CNN-LSTM Model
Authors: Reddy B Ramakantha , R Lokesh Kumar
Published: December 2022

Automated health care products classification is a challenging field of research that has recently gained a lot of interest. This process is beneficial in terms of time and cost but problematic in obtaining annotated data and lacks uniformity. The high volume of healthcare products and their categories raise the need for machine learning models that can decrease the time and cost spent by human editors. Deep learning techniques that have recently emerged are applied to automated healthcare data classification. The efficacy of the deep learning model depends on the training data and the learning model's suitability for the data domain. When the dataset is large, training a model requires potent processors, including GPUs and might take hours. However, when such a large volume of data is unavailable, the Conventional Neural Network (CNN) does not train well for the lack of enough samples. To overcome this issue, an effective classification method is proposed to classify the products with a contemporary architecture that integrates the data selection, transformation, and filtering processes with the training of CNN and long short-term memory (LSTM) with limited labeled data and has an imbalance among the classes. Finally, the proposed approach demonstrates that using an efficient classifier at the end of the CNN structure delivers the desired performance even when the CNN model is not intensely trained.
Palatal myoclonus and hypertrophic olivary degeneration following Wernekinck Commissure Syndrome: a case report
Authors: Zhang Qian , Guo Jiahuan , Zhao Xingquan , Zhang Xinghu , Ma Yuetao
Published: December 2022

Background
Hypertrophic olivary degeneration (HOD), a rare form of transsynaptic degeneration, is secondary to dentato-rubro-olivary pathway injuries in some cases. For the first time, we describe a HOD patient who presented with palatal myoclonus secondary to wernekinck commissure syndrome caused by a rare bilateral “heart-shaped” infarct lesion in the midbrain.
Case presentation:
A 49-year-old man presented with progressive gait instability in the past 7 months. The patient had a history of posterior circulation ischemic stroke presenting with diplopia, slurred speech, and difficulty swallowing and walking 3 years ago. The symptoms improved after treatment. The feeling of imbalance appeared and aggravated gradually in the past 7 months. Neurological examination demonstrated dysarthria, horizontal nystagmus, bilateral cerebellar ataxia, and 2–3 Hz rhythmic contractions of the soft palate and upper larynx. Magnetic resonance imaging (MRI) of the brain performed 3 years prior to this admission showed an acute midline lesion in the midbrain exhibiting a remarkable “heart appearance” on diffusion weighted imaging. MRI after this admission revealed T2 and FLAIR hyperintensity with hypertrophy of the bilateral inferior olivary nucleus. We considered a diagnosis of HOD resulting from a midbrain heart-shaped infarction, which caused wernekinck commissure syndrome 3 years ago and later HOD. Adamantanamine and B vitamins were administered for neurotrophic treatment. Rehabilitation training was also performed. One year later, the symptoms of this patient neither improved nor were aggravated.
Conclusion
This case report suggests that patients with a history of midbrain injury, especially Wernekinck commissure, should be alert to the possibility of delayed bilateral HOD when new symptoms occur or original symptoms are aggravated.
Difference of fatigue in patients on peritoneal dialysis versus hemodialysis and the association with nutrition and inflammation: a cross-sectional study
Authors: Peng Xinyue , Yang Fengjie , Wu Hong , Ouyang Qin , Li Yuxin , Wang Jianwen
Published: December 2022

Background Fatigue not only has a high incidence in dialysis patients, but also has a serious adverse impact on the quality of life of dialysis patients. To compare the difference of fatigue in patients on peritoneal dialysis (PD) versus hemodialysis (HD), and explore the association of fatigue with nutrition and inflammation of patients on PD or HD. Our study will provide a basis for the prevention and intervention of fatigue in dialysis patients. Methods A cross-sectional study was used. Questionnaire survey and clinical data collection were performed for patients received regular PD or HD in our hospital between June 2019 and January 2020. The difference of fatigue was compared between patients on different dialysis. Pearson correlation analysis was performed to explore the association of fatigue with nutrition and inflammation, and multivariate stepwise regression was performed to explore the influencing factors of fatigue in patients on PD and HD. Results The prevalence of fatigue in patients on PD and HD was 97.5% and 98.9% respectively, and the percentage of patients with moderate fatigue was the highest. Fatigue in patients on PD was positively correlated with white blood cells(WBC), and negatively correlated with hemoglobin(Hb), albumin(ALB), prealbumin(PALB), and serum iron(SI). Fatigue in patients on HD was positively correlated with WBC and platelet(PLT), and negatively correlated with Hb and ALB. Multivariate stepwise regression showed that serum ALB, WBC, Hb, and SI were major influencing factors for fatigue in patients on PD, and serum ALB was the major influencing factor for fatigue in patients on HD. Conclusions The prevalence of fatigue is relatively high in patients on dialysis. The general fatigue and physical fatigue in patients on PD are both lower than patients on HD. Inflammation and nutrition are major influencing factors for fatigue in patients on dialysis.
Dyshomeostasis of iron and its transporter proteins in cypermethrin-inducedParkinson’s disease
Authors: Sachan Nidhi , Tiwari Neha , Patel Devendra Kumar , Katiyar Diksha , Saripella Srikrishna , Singh Mahendra Pratap
Published: December 2022

The aetiology of Parkinson’s disease (PD) is highly complex and is still indefinable. However, a number of studies have indicated the involvement of pesticides and transition metals. Copper, magnesium, iron and zinc haveemerged asimportantmetal contributors. Exposure to pesticides cause an accumulation of transition metals in the substantia nigra (SN) region of brain. Cypermethrin model of PD is characterized with mitochondrial dysfunction, autophagy impairment, oxidative stress, etc. However, the effect of cypermethrin on metal homeostasis is not yet explored. The study was designed to delineate the role of metals and their transporter proteins in cypermethrin-induced animal and cellular models of PD. Level of copper, magnesium, iron and zinc waschecked in the nigrostriatal tissue and serum by atomic absorption spectroscopy. Since cypermethrin consistently increased iron content in the nigrostriatal tissue and serum after 12 weeks of exposure, level of iron transporter proteins, such asdivalent metal transporter-1 (DMT-1), ceruloplasmin, transferrin, ferroportin and hepcidin and their in silico interaction with cypermethrin were checked. 3,3′-Diaminobenzidine-enhanced Perl’s staining showed anelevated number of iron positive cells in the SN of cypermethrin-treated rats. Molecular docking studies revealed a strong binding affinity between cypermethrin and iron transporter protein receptors of human andrat. Furthermore, cypermethrin increased the expression of DMT-1 and hepcidin while reduced the expression of transferrin, ceruloplasmin and ferroportin in the nigrostriatal tissue and human neuroblastoma cells. These observations suggest that cypermethrin alters the expression of iron transporter proteins leading to iron dyshomeostasis, which could contribute to dopaminergic neurotoxicity.
Checking the rationality of a kind of Theta Functions by starting with a formula of Poisson
Authors: Louiz Akram
Published: December 2022

This is a mathematical example and a logical opportunity for those who doubt the summation of Poisson orthe related definitionsof Riemann. By using a formula of Poisson, this article makes a mathematical proof byconsidering that a limit of a sum is rational. Finally, you will find a logical explanation based on mathematicalprinciples that may be helpful for all students of Analysis who will find a new opportunity to demonstrate.
Sluggish dislocation mobility and high propensity for cross-slip at elevated temperatures in the MoNbTi Refractory Multi-Principal Element Alloy
Authors: Jones Morgan , Fey Lauren , Beyerlein Irene
Published: December 2022

Numerous body-centered cubic (bcc) refractory multi-principal element alloys (RMPEAs) exhibit high-temperature strength that surpass the performance of Ni-based superalloys. The superior properties of RMPEAs have been shown to stem in part from the unique dislocation glide mechanisms in a compositionally disordered system. Here, we assess the temperature-dependent mobility of edge and screw dislocations in MoNbTi with a bcc, random solid solution microstructure. When both dislocation types are subjected to a Schmid stress state, we find that mobility is low compared to glide in pure Nb. Interestingly, the edge/screw mobility ratio is found to increase with temperature in MoNbTi due to sustained sluggish screw mobility. Under a non-Schmid stress state, it is revealed that cross-slip occurs more easily in MoNbTi than in Nb and at elevated temperatures.These findings support the notion that sluggish glide in RMPEAs contributes to high-temperature strength, while easy cross-slip contributes to high strain hardening.
Mesoporous FeCo2O4 nanosheet-supported Pt for oxygen reduction and oxygen evolution reaction bi-functional catalytic performance
Authors: Li Sirong , Zhao Mengyao , Wang Zhenlong , Zhang Zhanyu , Yan Zhiyong , Xiao Xuechun
Published: December 2022

The development of new energy storage and conversion pathways has gradually freed people from dependence on oil, and improving conversion efficiency and safety is still the mainstream trend in the development of new energy sources, and electrode catalysts have become crucial in solving these problems. At present, precious metal catalysts have good performance, but the scarcity of resources and the high price limit commercialization. Therefore, it is very important to develop a catalyst for commercialization. In this paper, the Pt nanoparticles were successfully loaded on the mesoporous FeCo2O4 nanosheet catalyst by the sodium borohydride (NaBH4) reduction method. The formation of the Pt-O bond results in covalent coupling between Pt and FeCo2O4. The increase in defect sites also facilitates improved catalytic activity. According to the test results, the ORR process is mainly carried out through the "4-electron reaction" pathway, and the main product is water, and the Tafel slope of Pt-FeCo2O4 (-73 mV dec-1) is smaller than that of Pt/C (-84 mV dec-1) and FeCo2O4 (-76 mV dec-1). The stability of Pt-FeCo2O4 to ORR (After 12 h, only 15.5 % current density loss) is significantly higher than that of commercial Pt/C. Meanwhile, in the OER process, Pt-FeCo2O4 (28.1 mA cm-2) has a higher current density than RuO2 (24.4 mA cm-2) and FeCo2O4 (15.1 mA cm-2). Therefore, Pt-FeCo2O4 can be used as a bifunctional catalyst to accelerate the ORR and OER processes, which has important theoretical research significance and commercial value.
Graph-Based Feature Extraction on Object-Centric Event Logs
Authors: Berti Alessandro , Herforth Johannes , Qafari Mahnaz , Aalst Wil M.P. van der
Published: December 2022

Process mining techniques are widely used to uncover performance and compliance problems. However, the traditional focus on a single object type (i.e., case) is a limiting factor
when considering real-life information systems.
Therefore, there is an increased interest in object-centric process mining.
This paper proposes a graph-based approach for feature extraction on object-centric event logs. The conversion of the event log
to a set of numeric vectors is the starting point for the application of any machine learning technique (classification, prediction, clustering, anomaly detection)
on top of the event data. However, while feature extraction on traditional event logs is established, object-centric event logs are more difficult to encode in numeric
features because the events are related to several interconnected objects. Here, we try to close this gap and propose techniques and tools implementing feature extraction on object-centric event logs. The usefulness of the proposed features
is discussed on top of four problems in a Procure-to-Pay process.
The role of FGF3 in the guidance of prethalamic GABAergic axons
Authors: Huang Hong , Chen Qingyi , Zhang Weiyun , Yu Shuyang , Zhang Chunping , Xu Zhengang , Xiao Li , Liu Fang
Published: December 2022

The thalamus plays a crucial role in ensuring faithful transfer of sensory information, except olfactory signals, to corresponding cortical areas. However, thalamic function is not simply restricted to relaying information to and from the cerebral cortex. The ability to modulate the flow of sensory information is supported by a second abundant neuronal type in the prethalamus, the inhibitory GABAergic neurons, which project inhibitory GABAergic axons to dorsal thalamic glutamatergic neurons. Here, expression analyses reveal that morphogen fibroblast growth factor (FGF)-3 is expressed in the chick hypothalamus during the trajectory of pioneer prethalamic axons. Then, usingin vitroanalyses in chick explants, we identify a chemorepellent effect of FGF3 on nearby prethalamic axons. Moreover, inhibition of FGF3 guidance functions indicates that FGF3 signaling is necessary for the correct navigation of prethalamic axons. To test which downstream pathway is involved in the navigation of prethalamic axons, we used expression analyses and loss of function studies. We find that FGF3 mediates prethalamic axonal guidance through the FGFR1 downstream pathway. Together, these results suggest that FGF3 expressed in the hypothalamus functions as a chemorepellent molecule to direct the pathway selection of neighbouring GABAergic axons.
Establishment and validation a prognostic nomogram for early-onset colon cancer patients in stage I-II
Authors: Li Dongdong
Published: December 2022

Purpose
The study aims to establish and validate a nomogram model to predict the survival of early-onset colon cancer patients in stage I-II.
Methods
The eligible patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database between 2012 to 2015.Patients were be divided into training group and validation group in a 7:3 ratio randomly. The significant prognostic factors were identified through univariate and multivariate analysis and they were be constructed nomogram model. The predictive performance of the nomogram was evaluated by the concordance index (C-index), calibration plots, decision curve analysis (DCA).
Results
Our study totally enrolled 3528 early-onset CC patients in stage I-II, of 2469 patients in the training cohort and 1059 in the validation cohort. Race, Marital status, and T stage were be confirmed the independent prognostic factors after univariate and multivariate analysis. The C-index of nomogram were 0.724 and 0.692 in the training and validation cohorts, respectively. Likewise, the calibration plots showed the good consistency in the probability of 3-, 5-years OS between the actual observation and the nomogram prediction in the training. The DCA showed the good clinical practical efficacy of the nomogram model. Moreover, the patients be divided into two different risk score groups in two cohorts based the nomogram. The low-risk group had a better survival than the high-risk group.
Conclusion
We developed and validated a meaningful prognostic nomogram model for stage I-II colon cancer patients of early-onset, which clinicians could apply it to make better decisions for individual patient.
A prospective, double-blinded cohort study using Quantitative fetal fibronectin testing in symptomatic women for the prediction of spontaneous preterm delivery
Authors: Ng Vivian Wai Yan , Seto Mimi Tin Yan , Lewis Holly , Cheung Ka Wang
Published: December 2022

Background
Quantitative fetal fibronectin (fFN) is under-utilised in Hong Kong. Our objective was to evaluate the effectiveness of quantitative fetal fibronectin (fFN) to predict spontaneous preterm birth in women with symptoms or signs of threatened preterm labour.
Methods
A prospective, double-blinded cohort study of women with a singleton gestation and with preterm labour symptoms presenting to a tertiary hospital in Hong Kong between 24 + 0 to 33 + 6 weeks was performed from 1st October 2020 and 31st October 2021. Women with vaginal bleeding, ruptured membranes, and cervical dilation > 3 cm were excluded. The primary outcome was spontaneous preterm birth < 37 weeks. Test characteristics of quantitative fFN at different thresholds were evaluated.
Results
48 women were recruited. 10 mothers had preterm delivery (< 37 weeks' gestation) and 9 delivered within 48 hours. The NPV to predicting delivery within 14 days is 97.3% using a cut-off of < 50ng/ml and it is 100% when using 10ng/ml as cut-off. On the other hand, using 200 ng/ml as cut-off can also reliably predict women who delivered within 48 hrs– 7 days with PPV of 100%; as well as PTB before gestation 34 weeks and before 37 weeks.
Conclusions
Quantitative fFN provides different thresholds in addition to the qualitative method (50 ng/mL) to discriminate the risk of preterm delivery in symptomatic women. The high negative predictive value could help clinicians ruling out preterm labour and reducing unnecessary interventions.
Hydraulic analogy: some of practical application and limits of applicability
Authors: Yakubov Joseph , Musabekov Bakhram
Published: December 2022

In the first part of the article, an essential aspect of the limits of applicability of the hydraulic analogy is shown. The assumption is that there is no acceleration along the vertical axis when the fluid flows in an open channel. The effect of vertical acceleration is estimated. The authors suggest that when using the method of towing models in a fixed layer of "shallow water" in experiments in a hydraulic channel, new unique possibilities arise for modelling aerodynamic processes, including those that are difficult or even unreproducible by known means of physical modelling. Analog technical devices are described and examples of visualized pictures of complex shock wave structures are shown.
Dysregulation of a lncRNA within the TNFRSF10A locus activates cell death pathways
Authors: Farkas Michael , Kaczynski Tadeusz , Husami Nadine , Au Elizabeth
Published: December 2022

TNFRSF10A (tumor necrosis factor receptor superfamily member 10A)encodes a cell surface receptor protein involved in apoptotic, necroptotic, and inflammatory pathways. Dysregulation ofTNFRSF10Ahas been implicated in sensitization to apoptosis and to the development of multiple diseases, yet little is known of theAC100861.1long noncoding RNA (lncRNA) that lies head-to-head withTNFRSF10A. Given its genomic positioning, we sought to investigate the function ofAC100861.1, focusing on its potential relationship withTNFRSF10Aand the role it may play in death receptor signaling. Using knockdown and overexpression strategies, we probed cell viability and examined transcript and protein level changes in key genes involved in apoptosis, necroptosis, and inflammation. Decreased cell viability was observed uponTNFRSF10Aoverexpression, regardless of whether the cells were subjected to the chemical stressor tunicamycin. Similarly, overexpression ofAC100861.1led to increased cell death, with a further increase observed under conditions of cellular stress. Knockdown ofTNFRSF10Aincreased cell death only when the cells were stressed, andAC100861.1knockdown exhibited no effect on cell death. Neither knockdown nor overexpression of either of these genes greatly affected expression of the other. ManipulatingAC100861.1, however, led to marked changes in the expression of genes involved in necroptosis and inflammatory cell signaling pathways. Additionally, RNA fluorescencein situhybridization (RNA-FISH) revealed that theAC100861.1transcript is localized primarily to the cytoplasm. Together, these data suggest thatAC100861.1may have a role in regulating necroptotic and inflammatory signaling pathways, and that this function is separate from changes inTNFRSF10Aexpression. Given the importance of this genomic locus for cell survival, these data provide insight into the function of a poorly understood lncRNA with potential implications regarding disease pathology and treatment.