bluuebunny/crossref_metadata_2025 huggingface dataset:
Guillaume du Vintrais, un poète huguenot au goulag stalinien
Authors: Vashkevich Nadezda
Published: December 2022

L’article étudie le sonnet dans sa dimension politique. Il établit une comparaison entre un poète ima­ginaire de la Renaissance, Guillaume du Vintrais, créé de toutes pièces par deux détenus de goulag, Youri Veynert et Yakov Kharon, et son célèbre prototype Clément Marot, poète français, humaniste et libertin, emprisonné et poursuivi en tant qu’adepte de la Réforme. Tous les deux, Guillaume du Vintrais et Clément Marot, choisissent la forme du sonnet afin d’exprimer leur idéal de liberté et dé­fendre la dignité humaine dans les conditions où toutes voix divergentes sont étouffées par le dogme. L’étude analyse la poétique subversive du poème amoureux dans les contextes sociaux et politiques en France dans les années 1530–1540 et en l’URSS dans les années 1930–1940. Malgré les quatre siècles qui séparent les deux époques, les règles de la joute qui oppose un oppresseur à un libre-penseur n’ont pas beaucoup changé.
BİR OSMANLI DEVLET ADAMININ PERSPEKTİFİNDEN İNSAN HAKLARI: MÜNİF PAŞA’NIN DOĞAL HUKUK YAKLAŞIMI
Authors: HACIFEVZİOĞLU Ahmet Umut , AKÇADAĞ Göknur
Published: December 2022

Aydınlanma tarihimizin önde gelen isimleri arasında yer alan Münif Paşa, başta eğitim olmak üzere bilim, kültür, ekonomi, dil, alfabe, kadın, çocuk eğitimi, kütüphanecilik, müzecilik, siyaset gibi farklı konularda düşünen, tartışan ve yazan bir Osmanlı aydını olmasının yanında hukuk felsefecisi kimliğiyle de dikkat çekmektedir. O, Osmanlı toplumunda kurulması için gayret sarf edilen yeni ve modern anlamda bir toplumsal yapının son kertede hukuka bağlı olduğunu düşünür. Münif Paşa söz konusu düşüncesi çerçevesinde gerek eserleriyle gerekse de Mekteb-i Hukuk’ta verdiği dersleriyle 19. yüzyılın ikinci yarısında Batı’da yaygın olarak kabul gören “Doğal Hukuk” anlayışını Osmanlı toplumuna tanıtan aydınlarımızdan biridir. Bilindiği üzere doğal hukukun biri klasik, diğeri modern iki ana şekli vardır. Onun Eski Yunan’da, Aristoteles’te, Stocacılıkta ve Orta Çağ Hıristiyan düşüncesinde görülen klasik şekli, doğal hukukun adaletin tecellisi olduğu düşüncesini kabul eder. Tanrı’nın iradesinde ya da insan doğasında temellenen doğal hukuk evrensel olmak durumundadır. Doğal hukuk anlayışının modern formu ise doğa yasalarının her bireye birtakım hak ve özgürlükler bahşettiğini öne sürer. Eserlerinde ve derslerinde gerek klasik gerekse de modern formu olmak üzere Batı’da tarih boyunca gelişen doğal hukuk düşüncesini tanıtan Münif Paşa, söz konusu hukukun insan haklarıyla ilgisine de dikkat çekmiştir. Yalnız şunu da belirtmek gerekir ki, içinde yaşadığı toplumun bakış açısını dikkate alan Münif Paşa, anılan eser ve derslerinde Batı kökenli doğal hukuk düşüncesinin körü körüne savunuculuğunu yapmamıştır. Batı’daki düşünce akımlarından etkilenen Münif Paşa’nın Aydınlanma’nın temel koyucu kavramlarından biri olan ilerleme düşüncesini savunduğu çeşitli çalışmalarda ele alınmakla birlikte, doğal hukuk görüşü bağlamında insan hakları kavrayışı ele alınmamıştır. Bu makalede Münif Paşa’nın insan hakları düşüncesi, doğal hukuk kavrayışı bağlamında ortaya koyduğu eser ve çalışmaları çerçevesinde ele alınmaktadır.
XIV. YÜZYILIN ORTALARINDA DÂRÜ’L-İRŞÂD İLE BEYTÜ’L-FEVÂHİŞ ARASINDA ERDEBİL’DE SOSYAL YAŞAM
Authors: MUSALI Namiq
Published: December 2022

XIV. yüzyıl ortalarında Erdebil şehri Safeviyye tarikatının merkezi konumuna sahip olup, mühim bir irşat merkezi (Dârü’l-İrşâd) olarak görülmekteydi. Ancak söz konusu döneme ait belge ve kaynakların detaylı bir şekilde araştırılması sonucunda Safeviyye şeyhlerinin bu şehirdeki irşat faaliyetlerinin hiç de kolay ilerlemediği anlaşılır. Önce İlhanlı, daha sonra ise Celayirli devletleri içinde önemli bir zanaat ve ticaret merkezi, uğrak yeri ve kavşak noktası olan Erdebil şehrinde sadece müminlerin ve sûfîlerin yaşadıkları düşünülemez. Bahse konu dönemde burada dinî kurallara özen göstermeyen bazı zümrelerin de geçici veya kalıcı olarak ikamet ettikleri bellidir. Bu yıllarda sosyal hayatın bir gerçeği, ekonomik ve ticari ilişkilerin bir parçası olarak Erdebil’de hırsızlık, şarapçılık, tefecilik, kumar ve fuhuş gibi İslâmiyet’le bir araya sığmayan olayların vuku bulduğu gözlemlenir. Makalemizde şehrin dindar kesiminin ve özellikle de Safeviyye Dergâhı’nın bu tarz temayüllere karşı mücadelesi ele alınmış ve bu bağlamda Beytü’l-Fevâhiş adlı genelevin kapatılmasına yönelik girişimler üzerine odaklanılmıştır. İlhanlıların son zamanlarında yapılan bu tarz girişimlerin hiçbirisi başarılı olamamıştır. Celayirliler döneminde Erdebil’de şarapçılığı ve fuhşu yasaklayan bazı fermanların verildiği bilinmektedir. Fakat bunlar bile bahsi geçen şehirde dinî muhite aykırı uğraş alanlarına son verilmesi için yeterli olmamıştır. Böylece birbiriyle tezat teşkil eden yaşam biçimleri paralel bir şekilde Erdebil’in sosyal yapısı içinde kendi varlığını sürdürmeye devam etmiştir.
İNGİLİZ BASININDA MİLLÎ MÜCADELE DÖNEMİNDE AYDIN
Authors: ULUDAĞ Mekki
Published: December 2022

Bu çalışmada İngiliz basınındaki haber ve yazılardan faydalanılarak Millî Mücadele dönemi boyunca Aydın’daki gelişmeler değerlendirilmiştir. Çalışmanın amacı, bir müttefik devlet olan Yunanistan’ın Aydın ve çevresindeki işgal faaliyetlerinin başka bir müttefik devlet olan İngiltere basını tarafından okuyucuya sunuş şeklinin ortaya çıkarılmasıdır. Yunan ordusunun Aydın ve çevresindeki işgal faaliyetleri İngiliz basını tarafından dikkatle takip edilmiş ve konu ile ilgili basında çokça haber ve makalenin yer aldığı tespit edilmiştir. İngiliz basınının bölgedeki Yunan işgalini sıkıca takip etmiş olmasının başlıca sebebi bölgedeki yoğun İngiliz ekonomik faaliyetleri olup İngiliz basınında sık olarak Yunan işgallerinin İngiliz çıkarlarına etkisi sorgulanmıştır. Böyle olmakla birlikte bu durum İngiliz basını vasıtasıyla Yunan işgaline dair önemli bilgilerin okuyucuya duyurulmasına sebep olmuştur. Bugüne dek böyle bir çalışmanın yapılmamış olması bu araştırmanın yapılmasının temel motivasyon kaynağı olmuştur. Bu araştırmada karşılaştırmalı analiz yöntemi kullanılmıştır. Buna göre öncelikle araştırılan konu ile ilgili olan haber ve yazılar tespit edilmiştir. Ardından objektiflik ilkesi esas alınarak ilgili haber ve yazılar tasnif edildikten sonra değerlendirmeye alınmıştır. Son aşamada değerlendirilmesine karar verilen haber ve yazıların içeriği yerli kaynaklardaki bilgiler ile kıyaslandıktan sonra araştırma kapsamına alınmıştır. Propaganda amaçlı yazıldığı ve gerçeklerle bağdaşmadığı açık bir şekilde tespit edilebilmiş olan haber ve yazılar araştırma kapsamının dışında tutulmuştur. Çalışmanın en önemli bulguları, Yunan ordusu tarafından Aydın ve çevresinde işlenmiş olan insanlık dışı suçlar ile ağır katliamların İngiliz basınında yer almış olması ve bölgede Yunanlıların istenmediklerinin açıkça belirtilmiş olmasıdır.
REMEMBERING AND FORGETTING IN UMBERTO ECO’S THE MYSTERIOUS FLAME OF QUEEN LOANA AND MURAT GÜLSOY’S NİSYAN (OBLIVION)
Authors: ALKAN Burcu
Published: December 2022

This article compares Umberto Eco’s The Mysterious Flame of Queen Loana (2004) and Murat Gülsoy’s Nisyan (2013, Oblivion) in terms of how they explore the relationship between memory and selfhood. The unique multi-layered ways in which the novelists depict remembering and forgetting render such a comparative analysis insightful. In The Mysterious Flame of Queen Loana, the protagonist, who suffers from memory loss following a stroke, embarks upon a journey of remembering to re-establish who he is/was. In this journey, the books he had read become his guide as he rebuilds his sense of self through his remembering of bookish memories. Approaching the topic from the opposite direction in Nisyan, Gülsoy portrays forgetting as a fragmentation of selfhood through a writer-narrator who suffers from dementia and struggles to write his final book. In his case, his scribbles of yellow pieces of post-it notes serve as the manifestation of the dissolution of his writerly self. The two characters of the two novels lean on the un/written word in their attempts at anchoring back to life as a reader and as a writer. In these narratives, the unreliable memory work becomes the precarious connection between life and death as the un/written word becomes the life force that holds together (or not) the broken structures of memory and selfhood.
FEAR AND REPULSION: THE ABJECT IN ROBINSON CRUSOE
Authors: ALBAYRAK Gökhan
Published: December 2022

This paper aims to explore Daniel Defoe’s Robinson Crusoe from a Kristevan perspective. Kristeva’s theory of abjection is employed to discuss the powers of horror and disgust in this novel. Fear and repulsion are so fundamental to the story of Crusoe, to the construction and disintegration of his Western self, a subject in process and on trial in the words of Kristeva. Therefore, this study deals with the abject and abjection in Robinson Crusoe and consists of two sections in accordance with Defoe’s bifurcated text. The first section focuses on how Crusoe is haunted by the abject and how the abject becomes manifest in his tale. It explores Crusoe’s banishment from humankind, expulsion from the symbolic domain of the knowable and nameable into the asymbolic realm of the incomprehensible, his fear of losing his human shape, of sinking into sheer animality, his constant terror of being devoured by beasts and savages, his obsession with cannibalism, his fear of death and his confrontation with the other. The other section concentrates on how Crusoe, a deviser of territories and an organiser of chaos, demarcates his universe, consolidates his boundaries to strive against the abject, and seeks to become a subject in his struggle against the abject. It discusses how the subject gives birth to himself by means of abjection. Since abjection sheds light on what is excluded or digested, this discussion of the novel is also intended to provide insights into what is dismissed from the confines of this novel.
SİYASİ BİR ROMAN OLARAK VEBA GECELERİ: ULUS İNŞASI VE ULUSAL TARİH YAZIMI
Authors: TARHAN Belgin
Published: December 2022

İlk bakışta bir veba hikayesi gibi görünen Orhan Pamuk’un Veba Geceleri aslında salgının ivmelendirdiği yönetim ve siyaset kriziyle birlikte büyüyen bir siyasal dönüşüm romanıdır. 1901 yılında baş gösteren salgın, Osmanlı Devleti’ne bağlı Doğu Akdeniz’de hayali bir ada olan Minger’de zamanın içinde barındırdığı koşulları aktive eden bir siyasal atmosfer yaratır. Birkaç asırdır süregelen nüfus hareketliliği, salgınların bulaşı gibi yeni fikir ve hareketlerin dolaşımına da hız katmıştır. Toplumların eşitlik ve özgürlük yönündeki talepleri halk isyanlarına, darbe ve devrimlere yol açarken geleneksel monarşileri tehdit eden bir güce erişmiştir.
Modern çağın siyasi roman klasiklerine girmeye aday bir anlatısı olmasına rağmen Veba Geceleri tarihi roman türü içine dahil edilerek yorumlanmakta ve değerlendirilmektedir. Yazarı Orhan Pamuk da bu yönelime öncülük eder görünmektedir. Böyle bir yaklaşım, romanı eksik ve sınırlı bir bakışa mahkûm etmektedir. Bu nedenle çalışmada, iki meseleye odaklanan bir tartışma yürütülmektedir. İlk kısım Veba Geceleri’nin niçin siyasi bir roman olarak okunması gerektiği sorusu etrafında gezinmektedir. İkinci kısımda, Veba Geceleri üzerinden edebiyatın kurmaca dünyasına yaklaşan ulusal tarih yazımının öne çıkan yanlarıyla birlikte siyasal arka planı tartışmaya açılmaktadır.
EUGÈNE IONESCO’NUN YENİ KİRACI ADLI OYUNUNDA TÜKETİM VE NESNELER
Authors: YASSITEPE AYYILDIZ Ece
Published: December 2022

Absürd tiyatro yazarı Eugène Ionesco, XX. yüzyıl insanını ve tüketim toplumunun bir portresini Yeni Kiracı adlı oyunda belirgin bir şekilde ortaya koymaktadır. “Bay” ismindeki burjuva karakter Paris’te bir apartman dairesi kiralamıştır ve kiraladığı bu daireye taşınacaktır. Bay’ın bu daireye taşınmasındaki en büyük zorluk, eşyalarının fazlalılığıdır; oyun boyunca gitgide artan ve evin içine sığmayan bu eşyalar bütün evi doldurmakla kalmayıp bütün şehri istila edecektir. Bu nedenle, fazla eşyaları yüzünden Bay eve yerleşmekte güçlük çekecek, aynı zamanda kendisi için evinde bir yaşam alanı kalmayacaktır ve ev onun mezarına dönüşecektir. Bu oyunda, Ionesco tiyatrosunu tanımlamak için kullanılan “prolifération ionescienne”, Türkçe ifadesiyle eşyaların çoğalmasını ifade etmektedir. Ionesco bu oyunda toplumsal eleştiri ve absürd tiyatro kuramını tam anlamıyla ortaya koymaktadır. Modern insanın tüketme arzusu, nesnelerin bireye olan üstünlüğü ve tüketim toplumunun yansıması açık bir şekilde gözlemlenmektedir. Ionesco’nun Yeni Kiracı oyunu bizi Jean Baudrillard’ın Nesneler Sistemi adlı çalışmasına yönlendirmektedir. Baudrillard, bu çalışmasında, nesnelerin insanlar üzerindeki etkisinden ve tüketim arzusundan söz etmektedir.
Bu makalede amacımız, Baudrillard’ın Nesneler Sistemi adlı eserinden yola çıkarak Ionesco’nun “mekanik bir bozulma” olarak adlandırdığı Yeni Kiracı oyununda yer alan nesnelerin üstünlüğünü Bay karakteri üzerinden incelemektir. Ionesco’nun Yeni Kiracı adlı oyununda taşınılacak eve ait olan bu nesnelerin özneleşmesini, giderek çoğalmasını ve bunun karakter üzerindeki etkisini ele alırken çalışmamız Baudrillard’ın kuramı çerçevesinde incelenecektir.
Organização dos serviços de atendimento a pacientes portadores de lesões de pele no Brasil
Authors: Dória João Pedro da Silva , Okuno Izadora Yumi Yamauti , Fernandes Flávia Emília Cavalcante Valença , Góis Amanda Regina da Silva , Brito Vieira Diniz Larissa , Mola Rachel
Published: December 2022

Introdução: A ocorrência das lesões de pele, independente da sua etiologia, demanda por vezes, do acompanhamento por serviços de saúde. Objetivo: Identificar na literatura científica, a organização dos serviços de atendimento a lesões de pele no Brasil. Métodos: Revisão integrativa realizada de janeiro a fevereiro de 2021, na Biblioteca Virtual em saúde, aplicando a estratégia PICO para formulação da pergunta norteadora. Resultados: Sete artigos foram analisados, emergindo categorias temáticas sobre a organização estrutural (estrutura física); material e de insumos (custos do tratamento); e funcional (protocolos de funcionamento) dos serviços. Foram identificadas inadequações referentes ao espaço físico das salas de curativo e equipamentos necessários na realização dos procedimentos; além de evidenciar a necessidade de sistematizar o cuidado prestado e capacitar o profissional. Conclusão: Foi possível identificar as potencialidades e carências existentes para a implementação do cuidado de qualidade ao paciente portador de lesão de pele, tendo as salas de curativo como cenário; além de contribuir para novos estudos, tornando o tema mais evidente para a comunidade científica e assistencial.
Avaliação de enfermeiros da Estratégia Saúde da Família acerca do atributo orientação familiar
Authors: Oliveira Milena de , Fiorenza Lorena Alves , Bergenthal Carolina Isabel , Eich Ânderson Rosauro , Soccol Keity Laís Siepmann , Marchiori Mara Regina Caino Teixeira , Santos Naiana Oliveira dos
Published: December 2022

Introdução: A Atenção Primária em Saúde é a porta de entrada do Sistema Único de Saúde e possui atributos essenciais e derivados para sua consolidação no Brasil. Objetivo: Avaliar o atributo derivado orientação familiar, na perspectiva dos enfermeiros da Estratégia Saúde da Família. Métodos: Trata-se de um estudo descritivo, transversal quantitativo realizado no período de março a maio de 2021, com 14 enfermeiros das Estratégias Saúde da Família do município de Santa Maria, que responderam o instrumento PCATool-Brasil (versão profissionais) e um questionário sociodemográfico de forma online. Resultados: O atributo derivado apresentou um escore de 7,9 considerado um elevado grau de orientação familiar. Conclusão: A avaliação, presença e extensão desse atributo, promove a garantia de um cuidado integral, universal e de qualidade para as famílias adscritas nas Estratégias Saúde da Família.
Humanização em enfermagem na terapia intensiva à luz da teoria de Wanda Aguiar Horta: um estudo reflexivo
Authors: Prado João Paulo , Vitor Elizabeth Miranda , Cândido Elisângela Maria de Paula F. , Dázio Eliza Maria Rezende , Resk Zélia Marilda Rodrigues
Published: December 2022

Introdução: As Unidades de Terapia Intensiva nas instituições hospitalares destinam-se ao atendimento a pacientes em situação de saúde crítica que necessitam de assistência contínua e especializada por uma equipe multiprofissional. Objetivo: Descrever a humanização da assistência de Enfermagem em Terapia Intensiva, à luz da Teoria das Necessidades Humanas Básicas de Wanda de Aguiar Horta. Métodos: Trata-se de um estudo reflexivo que contou com o auxílio de publicações relacionadas a proposta, realizada uma revisão narrativa com o percurso metodológico utilizando os descritores Humanização da assistência, Unidade de Terapia Intensiva; Teoria de Enfermagem, nas bases de dados BDEnf, Lilacs, Bireme, PubMed no período de 2014 e 2022. Resultados: A humanização da assistência em Enfermagem na Terapia Intensiva, à luz da Teoria de Wanda Horta classifica as necessidades humanas em 3 grandes dimensões: psicobiológicas; psicossociais e psicoespirituais. Conclusão: A formação dos profissionais deve ser pautada nas raízes da Enfermagem por meio de suas teorias para reconhecer e utilizar sua ciência nos dias atuais como construção do cuidado humanizado em Enfermagem.
Ensino Remoto Emergencial na pandemia SARS-CoV-2 e morbidade autorreferida por adolescentes de curso técnico
Authors: Parreira Leiny Cristina Flores , Soler Zaida Aurora Sperli Geraldes , Rodrigues Luciene Cavalcanti
Published: December 2022

Objetivo: Verificar a percepção de adolescentes de curso técnico integrado quanto ao ensino remoto emergencial durante a pandemia SARS-CoV-2 e a morbidade autorreferida neste período. Métodos: Este estudo foi aprovado pelo Comitê de Ética em Pesquisa da Faculdade de Medicina de São José do Rio Preto e do Instituto Federal de São Paulo. Estudo com abordagem quantitativa, descritiva e correlacional sobre o Ensino Remoto Emergencial ofertado a 223 estudantes (amostra) de curso técnico e tecnológico na pandemia. Para a análise dos dados utilizou-se o programa Microsoft Excel® e o programa Statistical Package for Social Science, versão 20.0. Resultados: Identificaram-se impactos negativos na organização do cotidiano de estudos dos estudantes; uma redução do poder econômico das famílias; 21,1% dos estudantes não participam das aulas síncronas; 20,6% não estavam satisfeitos com o curso. Houve aumento de uso de medicamentos. Houve aumento em problemas de saúde como dores no estômago, de cabeça, outras dores, dificuldade de dormir e de permanecer dormindo, problemas de concentração, esquecimento, ansiedade, estresse, frustração, tédio, desânimo e outros desconfortos e fragilidades. Conclusão: As relações entre professor e aluno precisam ser reconstruídas, renovadas e a reestruturação da trajetória curricular propicie melhores condições de aprendizagem.
Existe relação de causalidade entre sarcopenia e dinapenia em pacientes submetidos à cirurgia bariátrica?
Authors: Takenami Luji Iseki , Santos Felipe Nunes Almeida , Santos Clarcson Plácido Conceição dos
Published: December 2022

Sarcopenia é definida, no idioma grego, como “pobreza de carne” e, a princípio, era tratada como o processo natural, relacionado ao envelhecimento, da perda de massa magra [1]. Esse conceito, no entanto, ainda não é estabelecido. Alguns autores limitam a sarcopenia apenas à perda de massa magra, outros a associam, também, à diminuição de força - denominada de dinapenia – unificando os dois conceitos [2]. A sarcopenia, por outro lado, não é vinculada somente ao processo de envelhecimento, visto que envolve um sistema multifatorial como a obesidade, por exemplo...
01. Annual spawn clump losses in a population of the agile frog Rana dalmatina in western France
Authors: ROGER MEEK
Published: December 2022

The agile frog Rana dalmatina is a common and frequently studied species in Europe including long-term studies of population change. Several have employed spawn clump counts to give estimates of annual presence of reproductive females. Spawn clumps are also subject to predation but little is known of the extent of losses but it could impact population densities significantly. The objective of the present study was to assess the extent of spawn clump losses due to predation in a population of R. dalmatina in western France using data from numbers of spawn clumps recorded over a four-year period (2019–2022). Spawn counts were greatest during 2019 but numbers declined with a zero count in 2022. Predation was greatest in 2021, the year total counts were lowest, but there were no statistical difference between annual losses, which varied from 22.9–41.6 %. Most spawn was deposited in a series of ditches rather than in the two available ponds but statistically predation levels were in agreement, with ditches ranging from 26.1–40 % versus ponds 28.6–40 %. Observed predators were ducks and alien crayfish Procambarus clarkii. The latter consumes all stages of frog development and hence likely represents the greater threat, especially since it has the capacity for population increase to very high numbers.
Pemanfaatan Limbah Cucian Beras Sebagai Pupuk Organik Cair (POC) Mendukung Ketahanan Pangan di Desa Mojosari, Kepanjen, Kabupaten Malang
Authors: Pitaloka Dyah , Abidin Zainal , Pratiwi Anggraeni Hadi , Hakim Arief Lukman , Handayani Sri , Murtadlo Ali
Published: December 2022

Air cucian beras mengandung nutrisi yang diperlukan untuk pertumbuhan tanaman, antara lain unsur N,P,K, Phospor, Besi, Protein Serat , Asam Amino dan Zink.  Pengabdian pada masyarakat ini bertujuan mensosialisasikan dan meningkatkan pengetahuan tentang khasiat limbah air cucian beras sebagai Pupuk Organik cair (POC) kepada Kelompok PKK Desa Mojosari Kecamatan Kepanjen Kabupaten Malang, kegiatan ini dilaksanakan pada tanggal 12 Juli 2022 bertempat di rumah ibu Yani salah satu anggota PKK di Desa. Metode yang dilakukan pada kegiatan ini meliputi pemaparan teori yang dilanjutkan dengan pendampingan pembuatan Pupuk Organik Cair (POC), menggunakan bahan limbah air limbah cucian beras yang difermentasikan. Hasil POC dimanfaatkan sebagai Pupuk Organik Cair di lingkungan Desa Merjosari selain digunakan sebagai starter untuk perbanyakan Kembali yang dilakukan secara mandiri oleh Kelompok PKK setempat.
Pembentukan UMKM Produsen Rendang Belut Khas Nagari Sungayang Dalam Rangka Pelestarian Makanan Tradisional Minangkabau
Authors: Fauziah Fitra , Deperiky Dedet , Oktavia Sri
Published: December 2022

Rendang belut merupakan salah satu makanan tradisional dari Nagari Sungayang, Kabupaten Tanah Datar, Sumatera Barat. Transformasi dunia digital ternyata turut mempengaruhi keberadaan dan kelestarian makanan ini. Kegiatan pengabdian ini bertujuan untuk meningkatkan kesadaran masyarakat menjaga kelestarian budaya makanan tradisional Minangkabau melalui pembentukan kelompok masyarakat produsen rendang belut khas Nagari Sungayang, sekaligus juga mendorong pertumbuhan ekonomi masyarakat Nagari Sungayang. Metode pengabdian dilaksanakan dengan memberikan bimbingan dan bantuan terhadap mitra mencakup bidang produksi, manajemen usaha, pemasaran, dan keuangan. Kegiatan pengabdian ini menghasilkan kelompok Usaha Mikro Kecil dan Menengah (UMKM) “Dapur Rang Sungayang”. Berdasarkan kegiatan yang telah dilaksanakan, kegiatan ini bermanfaat dalam pelestarian budaya makanan tradisional Minangkabau dan meningkatkan kemandirian ekonomi masyarakat.
THE EFFECT OF CREAM-BASED APPLICATION OF MORINGA LEAF (MORINGA OLEIFERA) EXTRACT ON THE INCISION WOUND HEALING ON WHITE RAT MANUSCRIPT
Authors: Adithia Felix Kurniawan , Oenarta Dave Gerald ,   Widya Mandala Surabaya Catholic University Indonesia, Dewi Bernadette Dian Novita ,   Widya Mandala Surabaya Catholic University Indonesia
Published: December 2022

Background: High injury incidence is a consideration of wound prevention with the prevalence of iris/torn/puncture injuries 20.1% in 2018. Indonesian people have a high level of confidence in traditional medicine and one of them is Moringa. Moringa phytochemical content has the potential to speed up the healing process of incision wounds. Purpose: This study aims to determine the effect of moringa leaf extract cream with concentrations of 5%, 15%, and 45% on the healing process of white rat incision wounds (Rattus norvegicus) by assessing the healing phase and using the Bates-Jensen Wound Assessment Tool (BWAT). Method: This research is experimental with a post-test-only control group design. Sampling by simple random sampling method and calculated using Federer's formula with the number of samples of 30 white rats divided into five groups, namely two groups of control and three treatment groups with 6 white rats in each group for 21 days. Results: In the analysis of BWAT score data with the MANNOVA test, there were insignificant results on day 1 (p=0.840) and day 7 (p=0.888), then there were significant results on day 14 (p=0.001). Post-hoc results showed significant differences between the negative control group and positive control over the 45% moringa leaf extract creaming group. In the analysis of healing phase data with the Kruskal-Wallis’s test, significant results were obtained in the coagulation phase (p=0.000) and the proliferation phase (p=0.001). The results of the Mann-Whitney test in the coagulation phase showed significant differences between the control and treatment groups while in the proliferation phase there were significant results between the control group and the treatment and there were no meaningful differences between the treatment groups. Conclusion: There is no significant difference in effectiveness between the administration of moringa leaf extract cream to accelerate the healing process of incision wounds.
How to establish electronic, scholarly, open access and peer-reviewed journal in small country
Authors: Trajkovski Vladimir
Published: December 2022

Introduction: publishing an electronic, peer-reviewed, open-access academic journal in a small country is really hard work. The advancement of electronic journals during recent years has given professionals in academia a powerful new tool to support learning and research.

The purpose of this article is to provide some guidelines about creating electronic, scholarly, open access and peer-reviewed journal in small country through the example of Journal of Health and Rehabilitation Sciences.

Methods: An analysis of relevant literature, sources from the Internet and published literature, personal experience and observations of the author as editor-in-chief in two similar journals previously.

Findings: a new modern academic journal should be open access, peer-reviewed, with international editorial board, having staff who work very dedicatedly. The journal should be set it up on OJS platform, using Creative Commons license for authors and DOI numbers for the articles. Plagiarism detection is a prevention of publication ethics violation. Journal editors should make additional efforts to index journal in lot of scholarly databases and to intend to increase the visibility. Sharing journal content on social media has become an important instrument and platform for editors and researchers as well.

Conclusions: Journal of Health and Rehabilitation Sciences (JHRS) is a multidisciplinary peer reviewed, international, electronic journal. Editorial office expects your submitted articles in the following weeks and months.
Multicriteria assessment of conservation agriculture systems
Authors: Adeux Guillaume , Guinet Maé , Courson Emeric , Lecaulle Sarah , Munier-Jolain Nicolas , Cordeau Stéphane
Published: December 2022

Conservation agriculture (CA) relies on three fundamental and inseparable pillars: no soil disturbance, diversified crop rotations, and permanent soil cover. Nevertheless, few studies have evaluated the interactive effect of these three fundamental pillars on a multicriteria basis. Here, we mobilize data from the French AGROSYST database, which gathers all farming practices and performances of the 3000 farms involved in the French DEPHY farmers’ network. Linear mixed effect models were used to compare the performance (13 indicators) of CA (CAs, N=36) and pseudo-CA systems (pseudo-CAs, N=19, allowing one occasional superficial tillage) to conventional tillage (plowed, CTs, N=135) and superficial tillage (STs, N=90) based systems in similar production situations (climate, soil type, presence of livestock or irrigation, etc.). CAs required (compared to STs and CTs, respectively) more herbicides (+27 and +90%) but slightly less insecticides (-64 and -50%, non-significant), decreased time of traction/ha/year (-25 and -32%), fuel consumption (-21 and -39%), as well as mechanization costs (-20 and -26%), tended to slightly decrease profitability/ha (-7 and -19%, non-significant) due to slightly lower productivity (-19% and -25%) but resulted in better profitability per hour of field traction (+23% and +18%). Pseudo-CAs did not implement the three CA principles since crop rotation were as diverse and cover crop as frequent as in STs and CTs, and tillage occurred, albeit rarely. However, pseudo-CAs used less insecticides (-92 and -83% compared to STs and CTs, respectively), decreased fuel consumption (-25% compared to CTs), and resulted in similar productivity and economic profitability (per hectare and per hour of field traction). Further investigation is required to identify the diversity of responses across production situations, the determinants of multi-performance in given production situations, and to track down the rare innovative systems optimizing multiple performances and solving apparent trade-offs.
Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
Authors: Obaíd Miguel L. , Carvajal Felipe , Camacho Juan Pablo , Corrales-Orovio Rocío , Martorell Ximena , Varas Juan , Calderón Wilfredo , Guzmán Christian Dani , Brenet Marianne , Castro Margarita , Orlandi Cecilia , San Martín Sebastián , Eblen-Zajjur Antonio , Egaña José Tomás
Published: December 2022

It is broadly described that almost every step of the regeneration process requires proper levels of oxygen supply; however, due to the vascular disruption in wounds, oxygen availability is reduced, being detrimental to the regeneration process. Therefore, the development of novel biomaterials combined with improved clinical procedures to promote wound oxygenation is an active field of research in regenerative medicine. This case report derives from a cohort of patients enrolled in a previously published ongoing phase I clinical trial (NCT03960164), to assess safety of photosynthetic scaffolds for the treatment of full skin defects. Here, we present a 56 year old patient, with a scar contracture in the cubital fossa, which impaired the elbow extension significantly affecting her quality of life. As part of the treatment, the scar contracture was removed, and the full-thickness wound generated was surgically covered with a photosynthetic scaffold for dermal regeneration, which was illuminated to promote local oxygen production. Then, in a second procedure, an autograft was implanted on top of the scaffold and the patient’s progress was followed for up to 17 months. Successful outcome of the whole procedure was measured as improvement in functionality, clinical appearance, and self-perception of the treated area. This case report underscores the long-term safety and applicability of photosynthetic scaffolds for dermal regeneration and their stable compatibility with other surgical procedures such as autograft application. Moreover, this report also shows the ability to further improve the clinical outcome of this procedure by means of dermal vacuum massage therapy and, more importantly, shows an overall long-term improvement in patient´s quality of life, supporting the translation of photosynthetic therapies into human patients.
Orthogonal pinhole-imaging-based learning salp swarm algorithm with self-adaptive structure for global optimization
Authors: Wang Zongshan , Ding Hongwei , Yang Jingjing , Hou Peng , Dhiman Gaurav , Wang Jie , Yang Zhijun , Li Aishan
Published: December 2022

Salp swarm algorithm (SSA) is a simple and effective bio-inspired algorithm that is gaining popularity in global optimization problems. In this paper, first, based on the pinhole imaging phenomenon and opposition-based learning mechanism, a new strategy called pinhole-imaging-based learning (PIBL) is proposed. Then, the PIBL strategy is combined with orthogonal experimental design (OED) to propose an OPIBL mechanism that helps the algorithm to jump out of the local optimum. Second, a novel effective adaptive conversion parameter method is designed to enhance the balance between exploration and exploitation ability. To validate the performance of OPLSSA, comparative experiments are conducted based on 23 widely used benchmark functions and 30 IEEE CEC2017 benchmark problems. Compared with some well-established algorithms, OPLSSA performs better in most of the benchmark problems.
Thermal-tolerant potential of ordinary Chlorella pyrenoidosa and the promotion of cell harvesting by heterotrophic cultivation at high temperature
Authors: Dai Yu-Ren , Wang Die , Zhu Yu-Rong , Yang Kun-Xiao , Jiao Ning , Sun Zhong-Liang , Wang Shi-Kai
Published: December 2022

During the heterotrophic cultivation of microalgae, a cooled process against temperature rise caused by the metabolism of exogenous organic carbon sources greatly increases cultivation cost. Furthermore, microalgae harvesting is also a cost-consuming process. Cell harvesting efficiency is closely related to the characteristics of the algal cells. It may be possible to change cell characteristics through controlling culture conditions to make harvesting easier. In this study, the mesophilic Chlorella pyrenoidosa was found to be a thermal-tolerant species in the heterotrophic mode. The cells could maintain their maximal specific growth rate at 40°C and reached 1.45 day−1, which is equivalent to that of cultures at 35°C but significantly higher than those cultured at lower temperatures. Interestingly, the cells cultured at 40°C were much easier to be harvested than those at lower temperatures. The harvesting efficiency of the cells cultured at 40°C reached 96.83% after sedimentation for 240 min, while the cells cultured at lower temperatures were reluctant to settle. Likely, the same circumstance occurred when cells were harvested by centrifugation or flocculation. The promotion of cell harvesting for cells cultured at high temperatures was mainly attributed to increased cell size and decreased cell surface charge. To the best of our knowledge, this is the first report that cells cultured at high temperatures can promote microalgae harvesting. This study explores a new approach to simplify the cultivation and harvesting of microalgae, which effectively reduces the microalgae production cost.
Epithelial morphogenesis in the Drosophila egg chamber requires Parvin and ILK
Authors: Keramidioti Athina , Golegou Evgenia , Psarra Eleni , Paschalidis Nikolaos , Kalodimou Konstantina , Yamamoto Shinya , Delidakis Christos , Vakaloglou Katerina M. , Zervas Christos G.
Published: December 2022

Integrins are the major family of transmembrane proteins that mediate cell-matrix adhesion and have a critical role in epithelial morphogenesis. Integrin function largely depends on the indirect connection of the integrin cytoplasmic tail to the actin cytoskeleton through an intracellular protein network, the integrin adhesome. What is currently unknown is the role of individual integrin adhesome components in epithelia dynamic reorganization. Drosophila egg chamber consists of the oocyte encircled by a monolayer of somatic follicle epithelial cells that undergo specific cell shape changes. Egg chamber morphogenesis depends on a developmental array of cell-cell and cell-matrix signalling events. Recent elegant work on the role of integrins in the Drosophila egg chamber has indicated their essential role in the early stages of oogenesis when the pre-follicle cells assemble into the follicle epithelium. Here, we have focused on the functional requirement of two key integrin adhesome components, Parvin and Integrin-Linked Kinase (ILK). Both proteins are expressed in the developing ovary from pupae to the adult stage and display enriched expression in terminal filament and stalk cells, while their genetic removal from early germaria results in severe disruption of the subsequent oogenesis, leading to female sterility. Combining genetic mosaic analysis of available null alleles for both Parvin and Ilk with conditional rescue utilizing the UAS/Gal4 system, we found that Parvin and ILK are required in pre-follicle cells for germline cyst encapsulation and stalk cell morphogenesis. Collectively, we have uncovered novel developmental functions for both Parvin and ILK, which closely synergize with integrins in epithelia.
The unexpected versatility of ALP/Enigma family proteins
Authors: Fisher Lucas A. B. , Schöck Frieder
Published: December 2022

One of the most intriguing features of multicellular animals is their ability to move. On a cellular level, this is accomplished by the rearrangement and reorganization of the cytoskeleton, a dynamic network of filamentous proteins which provides stability and structure in a stationary context, but also facilitates directed movement by contracting. The ALP/Enigma family proteins are a diverse group of docking proteins found in numerous cellular milieus and facilitate these processes among others. In vertebrates, they are characterized by having a PDZ domain in combination with one or three LIM domains. The family is comprised of CLP-36 (PDLIM1), Mystique (PDLIM2), ALP (PDLIM3), RIL (PDLIM4), ENH (PDLIM5), ZASP (PDLIM6), and Enigma (PDLIM7). In this review, we will outline the evolution and function of their protein domains which confers their versatility. Additionally, we highlight their role in different cellular environments, focusing specifically on recent advances in muscle research using Drosophila as a model organism. Finally, we show the relevance of this protein family to human myopathies and the development of muscle-related diseases.
Isoprenoid alcohols utilization by malaria parasites
Authors: Bofill Verdaguer Ignasi , Sussmann Rodrigo A. C. , Santiago Verônica Feijoli , Palmisano Giuseppe , Moura Gabriel Cândido , Mesquita Juliana Tonini , Yamaguchi Lydia Fumiko , Kato Massuo Jorge , Katzin Alejandro Miguel , Crispim Marcell
Published: December 2022

Plasmodium falciparum is the etiological agent of human malaria, one of the most widespread diseases in tropical and subtropical regions. Drug resistance is one of the biggest problems in controlling the disease, which leads to the need to discover new antimalarial compounds. One of the most promissory drugs purposed is fosmidomycin, an inhibitor of the biosynthesis of isoprene units by the methylerythritol 4-phosphate (MEP) pathway, which in some cases failed in clinical studies. Once formed, isoprene units are condensed to form longer structures such as farnesyl and geranylgeranyl pyrophosphate, which are necessary for Heme O and A formation, ubiquinone, and dolichyl phosphate biosynthesis as well as for protein isoprenylation. Even though the natural substrates of polyprenyl transferases and synthases are polyprenyl pyrophosphates, it was already demonstrated that isoprenoid alcohols (polyprenols) such as farnesol (FOH) and geranylgeraniol (GGOH) can rescue parasites from fosmidomycin. This study better investigated how this rescue phenomenon occurs by performing drug-rescue assays. Similarly, to FOH and GGOH, it was observed that phytol (POH), a 20-carbon plant isoprenoid, as well as unsaponifiable lipid extracts from foods rescue parasites from the antimalarial effect of fosmidomycin. Contrarily, neither dolichols nor nonaprenol rescue parasites from fosmidomycin. Considering this, here we characterized the transport of FOH, GGOH, and POH. Once incorporated, it was observed that these substances are phosphorylated, condensed into longer isoprenoid alcohols, and incorporated into proteins and dolichyl phosphates. Through proteomic and radiolabelling approaches, it was found that prenylated proteins are naturally attached to several isoprenoids, derived from GGOH, dolichol, and POH if exogenously added. Furthermore, the results suggest the presence of at least two promiscuous protein prenyltransferases in the parasite: one enzyme which can use FPP among other unidentified substrates and another enzyme that can use GGPP, phytyl pyrophosphate (PPP), and dolichols, among other substrates not identified here. Thus, further evidence was obtained for dolichols and other isoprenoid products attached to proteins. This study helps to better understand the apicoplast-targeting antimalarial mechanism of action and a novel post-translational modification of proteins in P. falciparum.
Extraction and purification of phycobiliproteins from algae and their applications
Authors: Kovaleski Gabriela , Kholany Mariam , Dias Lília M. S. , Correia Sandra F. H. , Ferreira Rute A. S. , Coutinho João A. P. , Ventura Sónia P. M.
Published: December 2022

Microalgae, macroalgae and cyanobacteria are photosynthetic microorganisms, prokaryotic or eukaryotic, living in saline or freshwater environments. These have been recognized as valuable carbon sources, able to be used for food, feed, chemicals, and biopharmaceuticals. From the range of valuable compounds produced by these cells, some of the most interesting are the pigments, including chlorophylls, carotenoids, and phycobiliproteins. Phycobiliproteins are photosynthetic light-harvesting and water-soluble proteins. In this work, the downstream processes being applied to recover fluorescent proteins from marine and freshwater biomass are reviewed. The various types of biomasses, namely macroalgae, microalgae, and cyanobacteria, are highlighted and the solvents and techniques applied in the extraction and purification of the fluorescent proteins, as well as their main applications while being fluorescent/luminescent are discussed. In the end, a critical perspective on how the phycobiliproteins business may benefit from the development of cost-effective downstream processes and their integration with the final application demands, namely regarding their stability, will be provided.
Strategies for mercury speciation with single and multi-element approaches by HPLC-ICP-MS
Authors: Favilli Laura , Giacomino Agnese , Malandrino Mery , Inaudi Paolo , Diana Aleandro , Abollino Ornella
Published: December 2022

Mercury (Hg) and its compounds are highly toxic for humans and ecosystems, and their chemical forms determine both their behavior and transportation as well as their potential toxicity for human beings. Determining the various species of an element is therefore more crucial than understanding its overall concentration in samples. For this reason, several studies focus on the development of new analytical techniques for the identification, characterization, and quantification of Hg compounds. Commercially available, hyphenated technology, such as HPLC-ICP-MS, supports the rapid growth of speciation analysis. This review aims to summarize and critically examine different approaches for the quantification of mercury species in different samples using HPLC-ICP-MS. The steps preceding the quantification of the analyte, namely sampling and pretreatment, will also be addressed. The scenarios evaluated comprehend single and multi-element speciation analysis to create a complete guide about mercury content quantification.
Biphenyls in Clusiaceae: Isolation, structure diversity, synthesis and bioactivity
Authors: Wang Youyi , Huang Qing , Zhang Li , Zheng Changwu , Xu Hongxi
Published: December 2022

Clusiaceae plants contain a wide range of biologically active metabolites that have gotten a lot of interest in recent decades. The chemical compositions of these plants have been demonstrated to have positive effects on a variety of ailments. The species has been studied for over 70 years, and many bioactive compounds with antioxidant, anti-proliferative, and anti-inflammatory properties have been identified, including xanthones, polycyclic polyprenylated acylphloroglucinols (PPAPs), benzophenones, and biphenyls. Prenylated side chains have been discovered in many of these bioactive substances. To date, there have been numerous studies on PPAPs and xanthones, while no comprehensive review article on biphenyls from Clusiaceae has been published. The unique chemical architectures and growing biological importance of biphenyl compounds have triggered a flurry of research and interest in their isolation, biological evaluation, and mechanistic studies. In particular, the FDA-approved drugs such as sonidegib, tazemetostat, daclatasvir, sacubitril and trifarotene are closely related to their biphenyl-containing moiety. In this review, we summarize the progress and development in the chemistry and biological activity of biphenyls in Clusiaceae, providing an in-depth discussion of their structural diversity and medicinal potential. We also present a preliminary discussion of the biological effects with or without prenyl groups on the biphenyls.
Sodium houttuyfonate effectively treats acute pulmonary infection of Pseudomonas aeruginosa by affecting immunity and intestinal flora in mice
Authors: Zhuang Tian , Hu Mengxue , Wang Jian , Mei Longfei , Zhu Xiaoxiao , Zhang Haitao , Jin Feng , Shao Jing , Wang Tianming , Wang Changzhong , Niu Xiaojia , Wu Daqiang
Published: December 2022

Introduction

Pseudomonas aeruginosa is a major nosocomial pathogen that frequently causes ventilator-associated pneumonia in specific populations. Sodium houttuyfonate (SH) has shown mild antibacterial activity against P. aeruginosa in vitro, but the mechanism of potent antimicrobial activity of SH against P. aeruginosa infection in vivo remains unclear.

Methods

Here, using the mouse pneumonia model induced by P. aeruginosa nasal drip to explore the therapeutic effects of SH.

Results

We found that SH exhibits dose-dependent therapeutic effects of reducing P. aeruginosa burden and systemic inflammation in pneumonia mice. SH ameliorates inflammatory gene expression and production of inflammatory proteins, such as interleukin-6 (IL-6), nuclear factor kappa-B (NF-κB) and toll-like receptor 4 (TLR4), associated with the TLR4/NF-κB pathway in mice with P. aeruginosa pneumonia. Furthermore, we analyzed the intestinal flora of mice and found that compared with the model group, the abundance and diversity of beneficial bacterial flora of SH treatment groups increased significantly, suggesting that SH can improve the intestinal flora disorder caused by inflammation. In addition, SH improves alpha and beta diversity index and reduces species abundance differences of intestinal flora in pneumonia mice.

Discussion

Taken together, our presented results indicate that SH may effectively alleviate the acute pulmonary infection induced by P. aeruginosa by reducing the disturbance of regulating immunity and intestinal flora in mice.