bluuebunny/crossref_metadata_2025 huggingface dataset:
Segmentation and Edge Detection Based on Modified ant Colony Optimization for Iris Image Processing
Authors: Biniaz Abbas , Abbasi Ataollah
Published: January 2015

Ant colony optimization (stocktickerACO) is a meta-heuristic algorithm inspired by food searching behavior of real ants. Recently stocktickerACO has been widely used in digital image processing. When artificial ants move in a discrete habitat like an image, they deposit pheromone in their prior position. Simultaneously, vaporizing of pheromone in each iteration step avoids from falling in the local minima trap. Iris recognition because of its great dependability and non-invasion has various applications. simulation results demonstrate stocktickerACO algorithm can effectively extract the iris texture. Also it is not sensitive to nuisance factors. Moreover, stocktickerACO in this research preserves details of the various synthetic and real images. Performance of ACO in iris segmentation is compared with operation of traditional approaches such as canny, robert, and sobel edge detections. Experimental results reveal high quality and quite promising of stocktickerACO to segment images with irregular and complex structures.
Parallel Pbil Applied to Power System Controller Design
Authors: Folly Komla
Published: January 2015

Population-Based Incremental Learning (PBIL) algorithm is a combination of evolutionary optimization and competitive learning derived from artificial neural networks. PBIL has recently received increasing attention in various engineering fields due to its effectiveness, easy implementation and robustness. Despite these strengths, it was reported in the last few years that PBIL suffers from issues of loss of diversity in the population. To deal with this shortcoming, this paper uses parallel PBIL based on multi-population. In parallel PBIL, two populations are used where both probability vectors (PVs) are initialized to 0.5. It is believed that by introducing two populations, the diversity in the population can be increased and better results can be obtained. The approach is applied to power system controller design. Simulations results show that the parallel PBIL approach performs better than the standard PBIL and is as effective as another diversity increasing PBIL called adaptive PBIL
A Survey of old and New Results for the Test Error Estimation of a Classifier
Authors: Anguita Davide , Ghelardoni Luca , Ghio Alessandro , Ridella Sandro
Published: January 2015

The estimation of the generalization error of a trained classifier by means of a test set is one of the oldest problems in pattern recognition and machine learning. Despite this problem has been addressed for several decades, it seems that the last word has not been written yet, because new proposals continue to appear in the literature. Our objective is to survey and compare old and new techniques, in terms of quality of the estimation, easiness of use, and rigorousness of the approach, so to understand if the new proposals represent an effective improvement on old ones.
B-Tree Algorithm Complexity Analysis to Evaluate the Feasibility of its Application in the University Course Timetabling Problem
Authors: Cruz Chvez Marco Antonio , Martnez Oropeza Alina
Published: January 2015

This paper presents a comparative analysis of complexity between the B-TREE and the Binary Search Algorithms, both theoretically and experimentally, to evaluate their efficiency in finding overlap of classes for students and teachers in the University Course Timetabling Problem (UCTP). According to the theory, B-TREE Search complexity is lower than Binary Search. The performed experimental tests showed the B-TREE Search Algorithm is more efficient than Binary Search, but only using a dataset larger than 75 students per classroom.
Dimensionality Reduction of Dynamic Mesh Animations Using HO-SVD
Authors: Romaszewski Michał , Gawron Piotr , Opozda Sebastian
Published: January 2015

This work presents an analysis of Higher Order Singular Value Decomposition (HOSVD) applied to reduction of dimensionality of 3D mesh animations. Compression error is measured using three metrics (MSE, Hausdorff, MSDM). Results are compared with a method based on Principal Component Analysis (PCA) and presented on a set of animations with typical mesh deformations.
Estimation of Engine Intake Air Mass Flow using a generic Speed-Density method
Authors: Vojtíšek Michal , Kotek Martin
Published: January 2015

SHRNUTÍ

Měření výfukových emisí spalovacích motorů během reálného provozu přenosnými zařízeními umístěnými na palubě vozidla (PEMS) je důležitou součástí hodnocení dopadu nových paliv a technologií na životní prostředí a lidské zdraví. Znalost aktuálního toku výfukových plynů je jedním z nezbytných předpokladů pro takové provozní měření. Jedním z nejjednodušších způsobů je výpočet z toku nasáveného vzduchu, který je vypočten z měřených otáček motoru a tlaku a teploty náplně v sacím potrubí. V této práci byl obecný algoritmus využívající odhad dopravní účinnosti libovolného běžného čtyřdobého motoru aplikován na tři produkční evropské motory běžně využívané v ČR: těžký a automobilový přeplňovaný vznětový motor, a atmosférický zážehový motor. Vypočtené průtoky nasávaného vzduchu byly porovnány s různými referenčními metodami. Výsledky ukazují, že nejistota stanovení toku nasáveného vzduchu obecným algoritmem je v řádu 10% pro většinu provozních režimů motoru, kromě případů recirkulace velké části výfukových plynů, kdy nejistota vzrůstá na desítky procent. Desetiprocentní nejistota pro motory bez vysoké míry recirkulace výfukových plynů je přijatelná pro mnohá, zvláště průzkumná a orientační, měření emisí za provozu, a může být snížena kalibrací algoritmu pro daný motor.
Creating a common symbol classification for a new historical geoportal of Poland
Authors: Panecki Tomasz
Published: January 2015

The crowd-sourcing approach should be implemented into a new historical geoportal of Poland due to its increasing potential in WebGIS. Registered users will be able to acquire spatial data from various map series. As it requires feature class harmonization, a common symbol classification should be proposed. It will be based on chosen topographic maps of Polish land from the 19th and 20th centuries. Feature classes derived from archival maps will be standardized and reclassified, but with no information lost. This will be done in four steps which require: data acquisition, map content harmonization, feature class typification and attribute table elaboration. In addition, four methods of data harmonization can be distinguished: symbol sequence, semantic analogies, spatial relations and a combined method. The paper covers the elaboration of two thematic layers - roads and railways based on three topographic maps (Austrian 1:75 000, German 1:100 000, Russian 1: 126 000).
The Warsaw soundscape - structure and specifics
Authors: Romanowska Małgorzata
Published: January 2015

The Warsaw soundscape has been examined according to the principles of acoustic ecology. The soundscape is the acoustic environment tested primarily by qualitative research. Warsaw residents were asked in a survey about their sound impressions and requirements for the Warsaw soundscape. The aim of this research was to learn both the conditions of acoustic environment and the needs of space users in accordance with the space category. The present and expected sound structures of five different categories of space were examined (residential areas, streets, city centre, tourist areas and green areas). Information on both the specific Warsaw sounds and the ideas for new sounds (which could be introduced into the city) was collected.
Thermal seasons in Warsaw during the period 1961-2013
Authors: Majewski Grzegorz , Przewoźniczuk Wiesława
Published: January 2015

This study determines the approximate duration of the thermal seasons in Warsaw, and investigates their long-term variability. The measurement data come from the Ursynów meteorological station at the Warsaw University of Life Sciences (WULS) (λE 21°02’52’’, φN 52°09’38’’, 102.5 m a.s.l.), situated in the south of Warsaw, and comprise mean diurnal air temperatures for the years 1961-2013. In order to identify thermal seasons, the method of five-day rolling averages was applied, which revealed a substantial year-by-year variability. The achieved results were close to those found by other methods for stations situated within the same climatic region. Over the analysed period, winters and springs have become shorter, whereas the other two seasons have become longer. Nevertheless, the positive trend was only statistically significant for thermal summers. The increasing length of the thermal summer in Warsaw Ursynów may be due to the influence of urban heat islands in built-up areas.
Measurement Uncertainty Evaluation Method Considering Correlation and its Application to Precision Centrifuge
Authors: Ling Mingxiang , Li Huimin , Li Qisheng
Published: January 2015

Measurement uncertainty evaluation based on the Monte Carlo method (MCM) with the assumption that all uncertainty sources are independent is common. For some measure problems, however, the correlation between input quantities is of great importance and even essential. The purpose of this paper is to provide an uncertainty evaluation method based on MCM that can handle correlated cases, especially for measurement in which uncertainty sources are correlated and submit to non-Gaussian distribution. In this method, a linear-nonlinear transformation technique was developed to generate correlated random variables sampling sequences with target prescribed marginal probability distribution and correlation coefficients. Measurement of the arm stretch of a precision centrifuge of 10-6 order was implemented by a high precision approach and associated uncertainty evaluation was carried out using the mentioned method and the method proposed in the Guide to the Expression of Uncertainty in Measurement (GUM). The obtained results were compared and discussed at last.
On the Implications of Knowledge Bases for Regional Innovation Policies in Germany
Authors: Hassink Robert , Plum Oliver , Rickmers Arne
Published: January 2015

Regional innovation policies have been criticised for being too standardised, one-size-fits-all and place-neutral in character. Embedded in these debates, this paper has two aims: first, to analyse whether industries with different knowledge bases in regions in Germany have different needs for regional innovation policies, and secondly, to investigate whether knowledge bases can contribute to the fine-tuning of regional innovation policies in particular and to a modern, tailor-made, place-based regional innovation policy in general. It concludes that although needs differ due to differences in knowledge bases, those bases are useful only to a limited extent in fine-tuning regional innovation policies
Setting the Ground for Global City Formation: Neoliberalisation and Local Elites in Frankfurt on the Main
Authors: Mössner Samuel , Freytag Tim
Published: January 2015

This paper approaches the global city concept from a local perspective taking into account the political action of local elites in times of urban neoliberalisation. Drawing on the empirical research carried out in Frankfurt (Main), we argue that the very beginnings of the global city formation were less a result of global processes superseding local ones, as is often argued, but rather emerged out of local political action contested by local protests. In the first part, we will revisit the global city concept and contrast it against a critique of urban neoliberalisation. The second focuses on reviewing the history of urban restructuring in the Frankfurt Westend during the 1960s and 1970s. We suggest that the transformation of the Westend into a “strategic site of global control” (Sassen 2011) has been constructed as a narrative in order to legitimise local forms of real estate speculation, marketisation of commodification. Our paper tries to unfold the logics and strategies of such neoliberal urbanisation by critically reflecting upon historical events since the 1960s
Regional Government and Regional Planning in the Hanover Region
Authors: Priebs Axel
Published: January 2015

The Hanover Region was created in 2001 as a new type of urban regional body. The article deals with the conditions and goals of this administrative reform. It examines factors that contributed to the success of the reform. It is emphasised that above all the region’s predecessors’ more than three decades of experience with regional tasks were crucial. Also important was the fact that the region was initiated by three ‘doers’ from the local level, starting a bottom-up process. Crucial for the region’s profile is solidarity between the municipalities with their different economic and social structures. This is guaranteed by the contribution that all municipalities pay to the region. The article also deals with the regional planning principles in the Hanover Region, which has attempted to prepare and maintain a comprehensive physical structure. It is pointed out that the main advantage of the Hanover Region is that there is political responsibility at the regional level with directly elected politicians
Appearance of Hürthle cell carcinoma soon after surgical extirpation of Hürthle cell adenoma and follicular adenoma of the thyroid gland
Authors: Ristevska Nevena , Stojanoski Sinisa , Pop Gjorceva Daniela
Published: January 2015

Background. Hürthle cell neoplasms could be benign (Hürthle cell adenoma) or malignant (Hürthle cell carcinoma). Hürthle cell carcinoma is a rare tumour, representing 5% of all differentiated thyroid carcinomas. The cytological evaluation of Hürthle cell neoplasms by fine needle aspiration biopsy (FNAB) is complicated because of the presence of Hürthle cells in both Hürthle cell adenoma and Hürthle cell carcinoma. Thus, the preoperative distinction between these two entities is very difficult and possible only with pathohistological findings of the removed tumour.

Case report. A 57-year old female patient was admitted at our Department, for investigation of nodular thyroid gland. She was euthyroid and FNAB of the nodules in both thyroid lobes were consistent of Hürthle cell adenoma with cellular atypias. After thyroidectomy the histopathology revealed Hürthle cell adenoma with high cellular content and discrete cellular atypias in the left lobe and follicular thyroid adenoma without cellular atypias in the right lobe. One year after substitution therapy, a palpable tumour on the left side of the remnant tissue was found, significantly growing with time, presented as hot nodule on 99mTc-sestamibi scan and conclusive with Hürthle cell adenoma with marked cellularity on FNAB. Tumorectomy was performed and well-differentiated Hürthle cell carcinoma detected. The patient received ablative dose of 100 mCi 131I. No signs of metastatic disease are present up to date.

Conclusions. The differences between Hürthle cell adenomas and Hürthle cell carcinomas could be clearly made only by histopathological evaluation. Patients with cytological diagnosis of Hürthle cell neoplasms should proceed to total thyroidectomy, especially if tumour size is > 1cm, FNAB findings comprise cellular atypias and/or multiple bilateral nodules are detected in the thyroid gland.
Febrile neutropenia in chemotherapy treated small-cell lung cancer patients
Authors: Kukec Renata Rezonja , Grabnar Iztok , Vovk Tomaz , Mrhar Ales , Kovac Viljem , Cufer Tanja
Published: January 2015

Background. Chemotherapy with platinum agent and etoposide for small-cell lung cancer (SCLC) is supposed to be associated with intermediate risk (10-20%) of febrile neutropenia. Primary prophylaxis with granulocyte colonystimulating factors (G-CSFs) is not routinely recommended by the treatment guidelines. However, in clinical practice febrile neutropenia is often observed with standard etoposide/platinum regimen. The aim of this analysis was to evaluate the frequency of neutropenia and febrile neutropenia in advanced SCLC patients in the first cycle of standard chemotherapy. Furthermore, we explored the association between severe neutropenia and etoposide peak plasma levels in the same patients.

Methods. The case series based analysis of 17 patients with advanced SCLC treated with standard platinum/etoposide chemotherapy, already included in the pharmacokinetics study with etoposide, was performed. Grade 3/4 neutropenia and febrile neutropenia, observed after the first cycle are reported. The neutrophil counts were determined on day one of the second cycle unless symptoms potentially related to neutropenia occurred. Adverse events were classified according to Common Toxicity Criteria 4.0. Additionally, association between severe neutropenia and etoposide peak plasma concentrations, which were measured in the scope of pharmacokinetic study, was explored.

Results. Two out of 17 patients received primary GCS-F prophylaxis. In 15 patient who did not receive primary prophylaxis the rates of both grade 3/4 neutropenia and febrile neutropenia were high (8/15 (53.3%) and 2/15 (13.3%), respectively), already in the first cycle of chemotherapy. One patient died due to febrile neutropenia related pneumonia. Neutropenic events are assumed to be related to increased etoposide plasma concentrations after a standard etoposide and cisplatin dose. While the mean etoposide peak plasma concentration in the first cycle of chemotherapy was 17.6 mg/l, the highest levels of 27.07 and 27.49 mg/l were determined in two patients with febrile neutropenia.

Conclusions. Our study indicates that there is a need to reduce the risk of neutropenic events in chemotherapy treated advanced SCLC, starting in the first cycle. Mandatory use of primary G-CSF prophylaxis might be considered. Alternatively, use of improved risk models for identification of patients with increased risk for neutropenia and individualization of primary prophylaxis based on not only clinical characteristics but also on etoposide plasma concentration measurement, could be a new, promising options that deserves further evaluation.
Anthropometric and Metabolic Characteristics of Patients with Type 2 Diabetes Mellitus and Hypochromia
Authors: Neamţu Marius Cristian , Crăiţoiu Ştefania , Miulescu Rucsandra Dănciulescu , Margină Denisa
Published: January 2015

Background and Aims. Previous studies have shown that hypochromia is a common finding in patients with chronic diseases. The aim of our study was to estimate the anthropometric and metabolic characteristics of patients with type 2 diabetes mellitus (T2DM) and hypochromia. Material and Methods. 30 patients with T2DM were recruited for this study. Patient demographics, relevant concomitant illnesses and medical history were recorded. Anthropometric, biochemical parameters (fasting plasma glucose - FPG, glycated hemoglobin -HbA1c, glomerular filtration rate - GFR) and morphology of blood smear were assessed. Patients diagnosed with diabetes and hypochromia constituted the study group and patients with type T2DM but without hypochromia constituted the control group. Results. The study showed no statistically significant differences on anthropometric and metabolic characteristics of patients with diabetes and hypochromia, compared with controls. Conclusions. We observed a high prevalence of hypochromia in diabetic patients (46.66%). Our findings suggest the need of screening for routine hematological tests in patients with T2DM.
The Use of Continuous Glucose Monitoring System in Combination with Individualized Lifestyle and Therapeutic Recommandations on Glycemic Control of Type 2 Diabetes Patients
Authors: Crăciun Anca-Elena , Bala Cornelia , Crăciun Cristian , Roman Gabriela , Georgescu Carmen , Hâncu Nicolae
Published: January 2015

Background and aims. The aim of our research was to evaluate the impact of short-time continuous glucose monitoring (CGM) on glycemic control evaluated by HbA1c and within-day glucose variability. We also assessed if the initiation of insulin therapy in conjunction with lifestyle recommendations may prevent the weight gain. Materials and

method. We included 28 patients with type 2 diabetes with 2 consecutive CGMS recordings available (baseline and follow-up) and for which were collected data on weight, body mass index (BMI), percentage (%) of body fat, visceral fat area, HbA1c and glycemic variability. Results. The HbA1c decreased significantly from 8.8% at baseline to 7.3% at follow-up (p <0.0001) in the whole group, and from 10.5% to 7.5% in the subgroup for which the insulin therapy was initiated at baseline (p=0.011). The BMI, % body fat and visceral fat area decreased significantly from 29.2 kg/m2 to 28.4 kg/m2; from 32.3% to 30.4%; and from 141.6 to 129.3 (cm2), respectively. No increase of these parameters was observed in the subgroup for which the insulin therapy was initiated at baseline. Conclusion. The use of CGMS in combination with individualized lifestyle and therapeutic recommendations may have a beneficial effect on glycemic control and may prevent the weight gain associated with insulin initiation.
Cognitive Disorders, Depressive Status and Chronic Complications of Type 2 Diabetes Mellitus
Authors: Tache Mirela , Tocut Sandra Milena , Dobjanschi Carmen
Published: January 2015

Background and aims: Depression and cognitive disorders were reported more frequently in patients with diabetes mellitus (DM). Our aim was to analyze the association of cognitive disorders and depression association with chronic complications of DM in a group of Romanian patients. Materials and methods: The data was analyzed from 181 patients, with a mean age of 58,3 years to whom we applied the MMSE (Mini- Mental State Examination) and MADRS (Montgomery-Asberg Depression Rating Scale) questionnaires. We also analyzed the presence of chronic DM complications, HbA1c and lipid profile. Results: Most patients with type 2 diabetes mellitus (T2DM) had mild cognitive impairment (92%), more common in the age group 50-59 years. Chronic macrovascular complications were present in 74.58%, while chronic microvascular complications were present in 61.87% of patients with T2DM who associated mild and moderate cognitive impairment (p = 0.013). The most common form of depression was mild depression (90.2%), present in most patients with DM, regardless of progression and type of treatment. MADRS depression test scores were statistically significant correlated with the presence of peripheral artery disease - PAD (p <0.001), ischemic heart disease - IHD (p <0.001) and chronic kidney disease - CKD (p =0.05). We did not find a statistically significant correlation with HbA1c and serum lipid values (p˃0,05). Conclusion: Chronic diabetes macrovascular complications (PAD, IHD) and CKD were more frequently associated with cognitive disorders and depression in patients with T2DM independent of the degree of metabolic control.
Diet and Lifestyle Guidelines for Diabetes: Evidence Based Ayurvedic Perspective
Authors: Sharma Rohit , Pk Prajapati
Published: January 2015

Background and Aims: Ayurveda strongly emphasize on preventive and promotive aspects of health rather than curative. Centuries ago, Ayurveda laid the concepts of Dinacharya (daily regimen for healthy living), Ritucharya (seasonal regimen for healthy living), Sadvaritta (moral conducts) and Achara Rasayana (social conducts) as well established guidelines for healthy diet and lifestyle; but in current era, hardly anyone aptly follow it. As a result, there is tremendous rise in lifestyle disorders as pandemics, diabetes being the most menacing among them. The aim of this review is to bring into the limelight the Ayurvedic dietary and lifestyle guidelines for prevention of type 2 diabetes and available factual research evidence validating it. Materials and methods: Ayurvedic recommendations for prevention of diabetes were rationally reviewed in light of published information from several articles. Publications in Pubmed, Scopemed, Dhara online and other allied databases covering fields of therapeutics, pharmacology, biomedicine and health were also screened and taken into study for the report. Conclusion: Ayurvedic lifestyle guidelines of adopting a healthy dietary pattern together with physical activity are valuable tools in the prevention of type 2 diabetes.
Long Term Complications of Diabetes – A Review
Authors: Vlad Ionuţ , Oieru Dana Sonia , Popa Amorin Remus , Zaharia Mihaela
Published: January 2015

It is estimated that subclinical DM (diabetes mellitus) has the onset about 10 years before the appearance of actual clinical manifestations, leading to uncontrolled chronic complications. Many trials have pursued the onset and evolution of the DM chronic complications in order to obtain a full picture that allows the development of prevention strategies, treatments and DM costs reduction.
Clinical aspects, management and outcome of brain arteriovenous malformations – results with microsurgery first policy
Authors: Sandu Aurelia Mihaela , Ciubotaru Vasile Gheorghe , Tataranu Ligia Gabriela , Tascu Alexandru , Bucur Narcisa , Neacsu Angela , Gorgan Mircea Radu
Published: January 2015

We performed a retrospective study, including patients operated for brain AVMs between 1999 and 2014, in the Clinic of Neurosurgery, Emergency Clinical Hospital Bagdasar-Arseni, Bucharest. 277 patients underwent surgery for brain AVMs. Mean age was 29.82 years. 195 patients (70.40%) presented with hemorrhage and 86 cases (31.05%) were admitted with seizures. We performed total resection of AVMs in 228 cases (82.31%) and subtotal resection in 49 cases (17.69%). Regarding patients with residual nidus, 16 of them underwent second surgery, 27 stereotactic radiosurgery Gamma Knife, 3 embolization and 3 refused further treatment. Modified Rankin Scale (mRS) improved following surgery (Z = -9.248, p = 0.000). Early complications (0-30 days) were encountered in 84 patients (30.32%). We found the following risk factors for postoperative complications occurrence: motor deficit (p = 0.006), co-morbidities (p = 0.023), higher mRS (p = 0.005), lower Karnofsky score (p = 0.003), lower GCS (p = 0.016), profound nidus (p = 0.001), eloquent aria (p = 0.000), large nidus (p = 0.000), multiple arterial territory (p = 0.000), deep feeding arteries (p = 0.000), higher number of feeding arteries (p = 0.000), deep venous drainage (p = 0.000), multiple draining veins (p = 0.000), higher Spetzler- Martin grade (p = 0.006), high flow (p = 0.000), vascular steel (p = 0.000), associated aneurysms (p = 0.010) and decompressive craniectomy (p = 0.019). Mortality was 6.1%. Microsurgery is the treatment of choice for brain AVMs. Surgical results are excellent, with low morbidity and mortality. Patients with poor surgical results belonged to the group admitted with severe altered general state, state of consciousness, massive hematomas and acute brainstem dysfunction. If part of the nidus cannot be safely surgical resected, stereotactic radiosurgery can provide definitive cure of the lesion.
Surgical treatment and outcome of cerebral cavernomas – a 10 years’ experience
Authors: Giovani A. , Sandu Aurelia , Neacsu Angela , Gorgan R.M.
Published: January 2015

Cavernous malformations (cavernomas) are congenital low flow angiographic occult vascular lesions with a high tencency to bleeding. The prevalence of cerebral cavernous vascular malformations is estimated to be 0.4% to 0.9%.2,7 CMs in deep locations, including the brainstem, thalamus, and basal ganglia, account for 9% to 35% of all malformations in the brain. We performed a retrospective 10 years study on 130 operated cerebral cavernomas and discussed the clinical status at presentation, the choice and timing of the surgical approach and the short and longterm follow up. The 130 operated cases were divided into a supratentorial 102 (78.46%) group and an infratantorial group 28 (21.53%). The average age at presentation was 43,62 years old (17-76) and there was no sex predominance, male/female = 1,44 (77/53). Only in 14 cases (10.76%) we could find multiple cavernomas which had relatives with multiple cavrnomas, but the familial inheritance was not studied, and only the symptomatic lesion was resected. We divided the outcome results reporting for agroup with superficial respectively profound lesions. The long term follow up for the patients in the profound lesions group showed that 31/37 (83,78%) of patients had a mRS between 0 and 2, and the rest had a poor long term outcome. After surgery there was no clinical deterioration in the superficial lesions group and 22 patients from those who presented in mRS 2 showed neurological improvement on long term follow up, meaning that 82,79% of patients had a 0 or 1 mRS. Microsurgery is the treatment of choice in symptomatic brain cavernomas, total resection being the only curative treatment, capable to prevent further bleeding and to offer an efficient control of seizures.
Thoracic spine type C injuries: injury profile, management and outcome
Authors: Checiu Gheorghe , Filip Cristian , Serban Daniel , Calina Niki Adrian , Podea Marius , Zamfir Costica , Exergian Florin
Published: January 2015

In the last years we observed an increased number of patients with multiple lesions after high energy accidents. Type C injuries of the thoracic spine are the most severe lesions, with the worse prognosis. The study analyzes the injury profile, management and outcome of all patients with thoracic spine, from T1- to T10, type C injuries treated in the Spinal Surgery Department of “Bagdsar- Arseni” Emergency Hospital, in the last 5 years. There were 26 patients admitted in the study, mostly male, 77%, with a mean age of 33.8 years. All of them were victims of high energy accidents, and all had spine injury associated with multiple lesions (head, thoracic, abdominal and limbs). We have chosen a posterior approach in all cases, with laminectomy or hemilaminectomy, permitting us to achieve all the major objectives of surgery, with the advantage of lower blood loss and a reduced operating time. The purpose of surgery was to achieve decompression of the spinal cord and stability of the thoracic spine. We treated 19 patient surgically and 4 patient conservative. Thoracic spine type C fractures remain a challenge for the spinal surgeon. These lesions require a multidisciplinary team approach for the treatment of associated lesions. The main goal of surgery is to achieve stability of the fractured segments. The timing for surgery is indicated mainly by associated respiratory problems.
Cerebral revascularization: direct versus indirect bypass. Case presentation and review
Authors: Giovani A. , Brehar F. , Gorgan R.M.
Published: January 2015

Since 1985 when the EC-IC bypass study results were published and less procedures were performed for cerebral ischemia, the EC-IC bypass even high or low flow and the IC-IC bypass as flow replacement procedures gain acceptance for many neurosurgical pathologies, from extrinsic and intrinsic tumors requiring large vessels sacrifice to large giant and fusiform aneurysms. In recent years, after the results of Carotid Occlusion Surgery Study (COSS) and the Japanese EC-IC trial published their results the indications for extracranial-intracranial (EC-IC) by-pass expanded, including both extracranial carotid artery occlusive disease and intracranial atherosclerotic disease. The authors make a literature review of the indications for cerebral revascularization, with focus on the direct STA-MCA and indirect (EDAMS) revascularization techniques as a treatment for ischemic stroke. They present two cases of Moyamoya disease one treated with combined approaches and one with indirect approach and discuss the technical skills the surgeon should acquire in order to perform an anastomosis, focusing on the details of STA-MCA bypass, concluding that a combined approach gives better neurological results visible shortly after the surgery.
Traumatic acute posterior fossa subdural hematoma – A case report and review of literature
Authors: Jaiswal Manish , Sundar Vijay , Gandhi Ashok , Purohit Devendra , Mittal R.S.
Published: January 2015

Traumatic subdural hematomas of the posterior fossa are rare but dangerous neurosurgical emergencies that require prompt diagnosis and management to avoid the uniformly poor outcome. We present a case of a teenager with severe TBI and acute subdural hematoma of the posterior fossa that deteriorated rapidly before surgery but eventually made a good recovery. We also the review the literature concerning traumatic posterior fossa subdural hematomas [PFSDH].
Massive infarction and cavernous sinus thrombosis: an uncommon complication of tooth extraction
Authors: Umamaheswara Reddy V. , Agrawal Amit , Hegde Kishor V. , Srikanth V. , Sahith Reddy K.
Published: January 2015

Cavernous sinus thrombosis (CAST) is a rare and potentially fatal complication following tooth extraction. In present case of a 55 year old male known case of diabetes mellitus underwent tooth extraction. After 5 days, he noticed swelling around the cheek, high grade fever, and frontal headaches. Diagnosis of alveolar abscess after inspection was made, for which incision and drainage was done. Next morning, he noticed that the cheek swelling progressed to left eye and there was CT brain was performed which showed hyperdense areas in cavernous sinus on left side and left sylvian fissure with hemorrhagic venous infarct in left temporal and frontal lobes. More caudal sections revealed mucosal thickness in left maxillary and ethmoidal sinuses, edema over cheek, preseptal orbital swelling, retro-orbital fat stranding and axial proptosis. A diagnosis of rhino-orbital infection from dental source with cavernous sinus extension causing left temporo-frontal hemorrhagic venous infarction was made Emergency surgery for decompression was performed but the patient did not responded to the treatment and succumbed to the infection. This case is a reminder that in patients with uncontrolled diabetes, undergoing dental procedures should be carefully dealt with appropriate antibiotic cover. Early signs like unilateral facial edema, orbital chemosis, edema, and proptosis should raise high index suspicion of cavernous
Flow Cytometry Analysis of Pparα Receptors in Metabolic Syndrome / Studiul Receptorilor Pparα prin Metoda Citometriei în Flux în Sindromul Metabolic
Authors: Popa Elena , Zugun-Eloae Florin , Zlei Mihaela , Jitaru Daniela , Pintilie Oana Maria , Coman Adorata Elena , Traian Maria , Ungureanu Didona Anca , Carasevici Eugen
Published: January 2015

Introduction. Metabolic syndrome (MS) is a cluster of distinct metabolic alterations with an increased cardiovascular risk. Peroxisome Proliferator-Activated Receptor - Alpha (PPARα), member of the nuclear receptor superfamily of transcription factors, is critically involved in the management of lipid metabolism during homeostasis or inflammatory stresses in various cell types and represents one of the therapeutic targets in MS. We analysed the PPARα expression in leukocytes of pacients with MS, in order to address PPARα involvement in these group of diseases. Material and method. Our study included 57 adult patients recruited under informed voluntary consent, investigated in order to establish whether they present MS, according to International Diabetes Federation (IDF) European guidelines and grouped in 2 lots: the MS Lot (26 patients) and control group, non-MS Lot (31 subjects). Common clinical and laboratory parameters targeted in MS evaluation were determined for all the studied cases. The expression levels of 2 molecules, PPARα and CD36 were evaluated in various circulating leukocyte populations of these patients by an optimized flow cytometry method. Statistic analysis clarifying the significance of value differences for various parameters measured was performed under SPSS and simple statistical tests (Pearson, t-Student, Chi -test). Results and discussion. The fluorescence staining for PPARα were significantly dimmer when comparing the cellular expression in eosinophils (p<0.05) of MS versus the Control group of subjects. Conclusions: Our study is the first to show that circulating eosinophils display significantly reduced PPARα protein expression in MS patients. The differences in key molecule expression in circulating leukocytes (like PPAR species, CD36, and other) might be evocatory for the endothelial dysfunction and obesity and might be of use in the therapeutic decision.
Comparing the anti-inflammatory effects of Simvastatin and Rosuvastatin by measuring IL-1β, IL-6 and TNF-α levels using a murinic caecal ligation and puncture induced sepsis model / Compararea efectelor anti-inflamatoare ale Simvastatinei și Rosuvastatinei măsurând nivelele serice ale IL-1β, IL-6 si TNF-α folosind un model de sepsis la șobolan indus prin ligatură și puncție cecală
Authors: Mărginean M Mihai , Trancă Sebastian , Ardelean-Maghiar (Mărginean) Alina , Dîrzu Dan , Huțanu Adina , Platon (Antal) Oana , Dobreanu Dan
Published: January 2015

Background: Sepsis is a systemic host response to an infection which may evolve into severe sepsis and septic shock. It raises many health care related concerns around the world, carrying almost 30% mortality rates and a high financial burden. The disease is characterized by the triggering of some inflammatory pathways that are ultimately proven deleterious to the host organism. Although antibiotics, fluid administration, vasopressor therapy and infectious source control remain the recommended management strategies, emerging scientific data proposes statins as a new line of treatment. These drugs were first introduced in clinical practice for their cholesterol-lowering effect but the inhibition of HMG-CoA reductase and cholesterol biosynthetic pathway exhibits some less studied effects generally referred to as pleiotropic: anti-inflammatory, antithrombotic, immunomodulatory and antioxidant properties. Objective: To asses and compare the anti-inflammatory effect of two statins - Simvastatin and Rosuvastatin - measuring blood levels of IL-1β, IL-6 and TNFα using a previously described murinic model of sepsis. Methods: We compiled four groups (C, n=7; SEP, SV, RV, n=8). Statins were administered in two doses 18 and 3 hours before surgical intervention. Sepsis was induced using the caecal ligation and puncture technique. Blood samples were obtained by venepuncture from each subject in day 1, 4, 7 and 14 (the last samples were obtained by cardiac puncture). Complete blood count, Procalcitonin, IL-1β, IL-6 and TNF-α levels were assessed. Results: White blood cell counts differed across the groups showing a higher count for the septic but untreated group. Procalcitonin reacted in all septic groups but both statin treated groups had lower levels when compared to untreated group. IL-1β levels were higher in the Rosuvastatin treated group. IL-6 levels were more heterogeneously dispersed but higher levels were noticed in the untreated septic group. The Simvastatin treated group had higher levels compared to the Rosuvastatin treated one. TNFα levels were higher in the septic untreated group and in the Rosuvastatin treated one. For the Simvastatin treated subjects, the level of TNFα was similar with the control group. Conclusion: We concluded that both drugs showed anti-inflammatory effects on the murinic CLP-induced sepsis model. Between the two, Simvastatin had greater impact by lowering blood levels of established pro-inflammatory markers.
Identification of Exonic Copy Number Variations in Dystrophin Gene Using Mlpa / Identificarea Variaţiilor Numărului de Copii în Gena Distrofinei Folosind Metoda Mlpa
Authors: Rusu Cristina , Sireteanu Adriana , Butnariu Lăcrămioara , Pânzaru Monica , Braha Elena , Mihăilă Doina , Popescu Roxana
Published: January 2015

Duchenne and Becker muscular dystrophies (DMD/BMD) are X-linked progressive muscle disorders determined by mutations of the dystrophin (DMD) gene. Multiplex Ligation - Dependent Probe Amplification (MLPA) is a simple, inexpensive and reliable test for molecular diagnosis of DMD gene mutations. It identifies exonic copy number variations in the DMD gene, but the test should be completed with sequencing analysis in case of single exon deletions/duplications. The aim of this study was to evaluate the efficiency of MLPA as a DMD mutation screening tool in affected males and carrier females, as well as to appreciate the frequency of different types of mutations and to check the validity of the “reading frame rule”. We have used MLPA for the detection of deletions/ duplications in DMD gene in 53 individuals (30 affected males and 23 asymptomatic female relatives) referred for evaluation and genetic counseling due to the clinical suspicion of DMD/BMD. In the affected males (21 DMD and 9 BMD) MLPA had a detection rate of 63.5% (53.5% deletions and 10% duplications). The most frequently deleted exon was exon 45 and the most frequent duplication involved exons 3-5, confirming the presence of the two hotspot mutation regions reported in the literature. Mutations detected in our study have a slightly different location compared to literature data. Reading frame rule was valid in 84% of our cases.
Prognostic value of immunohistochemical expression of ZAP-70 and CD38 in chronic lymphocytic leukaemia detected on bone marrow and lymph node biopsies / Valoarea prognostică a expresiei imunohistochimice a ZAP-70 si CD38 în leucemia limfocitară cronică detectată pe biopsii osteomedulare și limfoganglionare
Authors: Fetica Bogdan , Fit Ana-Maria , Blaga Luminița , Fulop Annamaria , Pop Bogdan , Dima Delia , Cucuianu Andrei , Petrov Ljubomir
Published: January 2015

Chronic lymphocytic leukemia (CLL) has a heterogeneous clinical course. Among useful markers in identifiyng patients with poor outcome are unmutated IgVH, ZAP-70 and CD38 expression. Both ZAP-70 and CD38 were shown to be capable of identifying aggressive CLL.

We analysed data from 35 patients diagnosed with CLL based on morphological and immunophenotypical criteria. In all cases peripheral blood immunophenotyping was performed as initial diagnostic test. Immunohistochemical expression of ZAP-70 and CD38 was evaluated on 21 cases of lymph node biopsies and 14 cases of bone marrow biopsies, performed at the time of diagnosis. In addition in-situ hybridization for EBER-1 was evaluated.

The median age of patients was 60 years and we noted a slight male predominance. The immunophenotypic criteria (C23

Prognostic information given by ZAP-70 and CD38 could be used in guiding treatment decisions and they probably should be recommended to all patients with B-CLL in trying to obtain a more clear profile of the disease at the time of diagnosis.
The relationship between micronutrients and anthropometric measurements in malnourished children / Relaţia între micronutrienţi şi măsurătorile antropometrice la copiii malnutriţi
Authors: Man Lidia , Man Adrian , Mărginean Cristina Oana , Pitea Ana Maria , Baghiu Maria Despina
Published: January 2015

Purpose: to evaluate the serum levels of micronutrients in children with nutritional disorders, and to find if there is a direct correlation between them and the anthropometric measurements. Materials and methods: the study was conducted on 125 children (0-18 years); the working group consisted in children with Z-score < -2 standard deviations for at least one anthropometric measurement, while the children without growth disorders were considered as controls. Thus, for each anthropometric measurement, we had different working/control groups that were used for the assessment of correlation with laboratory findings. We followed eight anthropometric parameters and their relation with five of the micronutrients (Ca, Mg, Fe, Zn and Cu). Results: no statistical differences were found in micronutrients serum levels between genders or provenance. Most mean serum levels of micronutrients were lower in the children with Z-scores < -2 standard deviations (except Cu). Mg and Ca were positively correlated with most of the anthropometric measurements. For Fe, Zn and Cu, we found no correlation with any of the anthropometric measures. Differences in mean serum levels were found for Mg, with lower values in children with low weight-forage and triceps-skinfold-thickness, and for Cu, with higher levels in children with low triceps-skinfold-thickness. The red blood cell indices were positively associated with Fe and Zn levels. Conclusions: correlations between the serum level of micronutrients and anthropometric evaluation scores were found for Mg and Ca, but not for Fe and Zn, which were instead directly correlated with red blood cells indices. Mg, Fe and Zn tend to present small serum values in children with growth deficits. Considering the costs, the routine evaluation of Zn and Cu serum levels in growth disorder suspicion is not justified in our geographic area.
Atypical case of B-cell Chronic Lymphocytic Leukemia presenting with extreme hyperleukocytosis / Hiperleucocitoză extremă într-un caz atipic de leucemie limfatică cronică cu celulă B
Authors: Bacârea Anca , Bănescu Claudia , Macarie Ioan , Köpeczi Judit Beáta , Dorcioman Bogdana
Published: January 2015

Very few cases of chronic lymphocytic leukemia (CLL) presenting with extreme hyperleukocytosis are reported in the literature. We describe the case of a 66 years old woman, with newly diagnosed CLL presenting with extreme hyperleukocytosis of 774.2 x 109/liter, Rai stage III and Binet stage C. The patient has no comorbidities and the CIRS score (cumulative illness rating scale) is well below 6, with normal creatinine clearance. Some other interesting aspects related with this case are the atypical immunophenotype, the expression of Cyclin D1, and the B hepatitis viral infection, which made her diagnosis and treatment challenging. The patient was tested for NOTCH1 mutation and it was positive. There is important evidence that NOTCH1 mutations are associated with rapidly progressive disease and resistance to treatment. The distinction of CLL from mantle cell lymphoma (MCL) is not always easy because some MCLs may mimic CLL clinically, histologically, and/or phenotypically. The hepatitis B prophylaxis for viral reactivation was not available an in the end the patient was treated only with fludarabine and cyclophosphamide, without rituximab. CD200 should be introduced in the routine panel for flow cytometry to distinguish CLL from mantle cell lymphoma and NOTCH1 mutation is associated with poor prognosis and should be evaluated at diagnosis. CLL with extreme hyperleukocytosis presentation is very rare and sometimes an atypical CLL may represent a diagnostic pitfall.
Egalitarian Awareness in the Capitalistic Reality. The Entanglement of Poverty and Wealth in Daily Social Sphere 25 Years after the System Change in Poland
Authors: Żuk Piotr
Published: January 2015

The purpose of the article is to illustrate the social order preferred by the Polish together with their assessment of the existing social inequalities. On the basis of the empirical material collected among the sample of 1000 respondents, the findings show manners of their definition of equity, perception of discrepancies between the ideal of equity and the existing real status, together with their assessment of the existing differences in the treatment of rich and poor people by various institutions (banks, police, hospitals, courts). The article also describes the causes of social inequalities as indicated by the respondents and their assessment of state policies in reference to them. The article concludes that 25 years after the collapse of “real socialism”, Polish society presents a firmly egalitarian awareness that is in conflict with the current market order.