bluuebunny/crossref_metadata_2025 huggingface dataset:
STOMACH SECRETORY FUNCTION UNDER MUSCLE LOAD IN THE CONDITIONS OF PHARMACOLOGICAL BLOCADE OF M-CHOLINORECEPTORS AND β-ADRENOCEPTORS
Authors: Kuznetsov A , Smelysheva L , Arkhipova O , Moskovkin A , Sazhina N
Published: November 2019

Aim. The article deals with establishing the effect of muscle load on the stomach secretory function in the conditions of partial pharmacological blockade of M-cholinoreceptors and β-adrenoceptors in patients with duodenal acidification. Materials and methods. 22 males aged 18–23 years participated in the study. The stomach secretory function at rest under a 30-minute cycle ergometer load of 36 900 kgm combined with a partial pharmacological blockade of M-cholinoreceptors (1.5 mg per kg of body mass) and β-adrenoceptors (0.6 mg obsidan per kg of body mass) was studied using gastric and gastroduodenal intubation. Results. The blockade of M-cholinoreceptors at muscle rest provoked a noticeable decrease in the total content of electrolytes (p < 0.01), enzymes (p < 0.001), HCL (p < 0.001), and proteolytic activity (p < 0.001) in gastric juice. The combined activity of atropine and physical load in the conditions of duodenal acidification inhibited the amount of secretion significantly to 49.9 ± 11.1%, HCl to 29.7 ± 9.4%, pepsinogen to 19.8 ± 7.4% (p ˂ 0.001). The blockade of β-adrenoceptors significantly decreased the stomach secretory function in the conditions of basal secretion and duodenal acidification. After using a 10% dried cabbage decoction as a stimulator we registered an increase in the amount of secretion up to 141.1 ± 12.2%, HCl discharge – to 186.3 ± 21.9%, and pepsinogen – to 188.5 ± 20.4%. The same tendency was registered for the cycle ergometer test in the conditions of the blockade of β-adrenoceptors. Conclusion. The effect of muscle load on the stomach secretory function contributes significantly to the role of the sympathetic nervous system. Duodenal acidification in the conditions of the blockade of β-adrenoceptors intensifies the inhibitory effect, while stimulation with a dry cabbage decoction improves the stomach secretory function.
REACTIVITY OF THE VEGETATIVE NERVOUS SYSTEM INFLUENCED BY NON-VERBAL INFORMATION
Authors: Baiguzhin P , Shibkova D , Kudryashov A , Baiguzhina O
Published: November 2019

Aim. The article deals with establishing the HRV indicators influenced by non-verbal information. Materials and methods. Vegetative nervous system reactions have been estimated under the influence of non-verbal information as a response to the emotional state of the passive repeaters. The functional status of the repeaters was influenced by an emotional video. A recipient was in an isolated room surrounded by the group of the passive repeaters and was not subjected to a direct influence of the emotional video. The assessment of the vegetative responses in repeaters has been performed using tone- and pulsometry, in recipients – using the mathematical and time-domain analysis of a cardiorhythmogram. ECG recording was synchronized with video demonstration and divided into 9 conditional stages, each of 100 cardiocycles. The reliability of differences has been assessed with the Wilcoxon non-parametric criterion. Results. The intensity of vegetative nervous system reactions in both groups has been registered during the stages preceded by a video demonstration. In recipients, the high frequency of the significant changes in RRNN, RMSSD, pNN50, HR, M, Mo, AMo, VRI proves body sensitivity to non-verbal information. The low variability of certain indicators such as VR, SDNN, AMo, VB, and SI allows us to establish their specificity. Conclusion. The presence and intensity of a vegetative reaction in the recipients is determined by the modality of the emotion formed in a passive repeater. This effect can be possibly considered as an emotional resonance in the recipient induced by asthenic emotions and the feeling of compassion and regret in the repeater as a response to an emotional video.
THE EFFECT OF 8 WEEK RESISTANCE EXERCISES ON BLOOD LIPIDS AND BLOOD SUGAR LEVELS IN SEDENTARY WOMEN
Authors: Turgut M , Bağır S , Bozkuş T , Talaghir L , Sarıkaya M
Published: November 2019

Aim. The purpose of this study was to investigate the effects of an eight-week resistance exercise program on blood fats and blood sugar in sedentary women. The study included 20 volunteers with a mean age of 31.70 ± 3.81 years. Materials and methods. Blood samples were taken by the experts in the appropriate laboratory environment in the morning before and after the resistance exercise program, which was administered 60 minutes 3 days a week for 8 weeks in the mornings on an empty stomach. Dependent groups t-test (Paired Sample T-Test) was applied to compare descriptive statistics with pre- and post-exercise values by using SPSS 22.0 package program. Results. There was a significant difference between GLU, Triglyceride, HDL, LDL, and total cholesterol levels before and after the resistance exercise program (p > 0.05). Conclusions. Resistance exercises have a positive effect on blood sugar and blood fat change. Therefore, we think that it can be used as protection from cardiovascular diseases, and if these exercises are applied regularly, they will have many positive results in terms of health.
FACTOR PROFILES OF FUNCTIONAL AND TECHNICAL FITNESS IN NORDIC COMBINED SKIERS DURING MULTIYEAR PREPARATION
Authors: Zebzeev V , Zekrin F , Zdanovich O
Published: November 2019

Aim. The article deals with establishing the differences in the functional and technical fitness of Nordic combined skiers during multiyear preparation. Material and methods. To establish the factor profiles of the functional and technical fitness in Nordic combined skiers, we examined athletes at different stages of multiyear preparation: 40 athletes – initial preparation, 35 athletes – 2-year training program, 40 athletes – more than 2-year training program, 30 athletes – sports performance enhancement. The structure of functional and technical fitness was established with the help of factor analysis. Results. The comparative analysis of the factor structure of functional and technical fitness in Nordic combined skiers revealed the significant differences at each stage of multiyear training. It was established that during the stage of initial preparation and 2-year training program the most important factors are the nervous system (eye-hand visual reaction time, reaction to a moving object, interference resistance) and jumping fitness (angle characteristics during the run-up, take-off, flight, and landing), which create favorable conditions for forming the basics of ski-jumping technique in Nordic combined skiers. After 2-year training program and at the stage of performance enhancement the leading factors of physical fitness are determined by the cardiovascular (the Ruffier test, recovery constant, and Health integral indicator) and respiratory (VO2max, the Shtange's and Hench's breath test) systems, as well as ski racing technique (angle characteristics at different phases), which are favorable for the enhancement of ski racing technique. Conclusions. The results obtained allow the coaches to effectively improve functional and technical fitness and adjust training loads to the specifics of a certain stage of multiyear training.
Student perceptions of group writing processes and feedback
Authors: Jolley Kym
Published: November 2019

In this pilot study, two second year writing classes at a university in
Japan completed two group writing tasks using Microsoft Word and Google
Docs. After both tasks were completed, the students (N=45) completed a short
survey containing Likert scale items about their preferences when writing
under the different conditions. Willing individuals also answered a second
survey containing open-ended questions to gain a deeper understanding about
the first survey results. Findings showed that the students preferred using
Google Docs for the writing tasks due to ease of use and submission of the
final document, as well as the ability to understand online written feedback
from the instructor.
Student perceptions of virtual reality use in a speaking activity
Authors: Kassim Samar , Witkin Neil , Stone Adam
Published: November 2019

The aim of this study was to discover what potential benefits of Virtual
Reality (VR) use students perceived in comparison to smartphone use in an
English-speaking activity. Two surveys were conducted over three
interventions in order to ascertain these student perceptions. Ten students
enrolled in an elective English class at a Japanese university engaged in an
English-speaking activity centered around the VR enabled application Google
Expeditions. Student perceptions showed that the immersive nature of VR
prompted communication, invoked a higher sense of presence, and greater
enjoyment in this speaking activity. However, a majority of students did not
perceive a difference in the amount of English spoken when comparing VR and
smartphone use.
CALL replication studies: getting to grips with complexity
Authors: Tschichold Cornelia
Published: November 2019

Calls for replication studies are becoming more frequent, and Computer Assisted Language Learning (CALL) has now reached sufficient maturity to offer numerous studies that lend themselves to replication. Realistic and successful replications rely on transparency in terms of data, results, and methodology. Two published studies in the area of vocabulary CALL will be discussed from the perspective of their suitability for replication: Franciosi, Yagi, Tomoshige, and Ye (2016) and Kim and Kim (2012). Alzahrani (2017) is a replication of Franciosi et al. (2016), confirming the findings with a markedly different learner group. The replication used the same methodology, a slightly modified list of target words, and Saudi participants. Kim and Kim (2012) compared vocabulary learning across three different screen sizes. The flashcard software is not specified any further, nor are the target words. While such an underspecified methodology is less likely to lead to a successful replication that can strengthen the validity and reliability of research results in our field, it can still provide a good training opportunity for students to learn about methodology in CALL.
Asynchronous online peer judgments of intelligibility: simple task,
complex factors
Authors: Yonesaka Suzanne M.
Published: November 2019

Pronunciation learners can benefit from peer feedback in a
Computer-mediated Communication (CMC) environment that allows them to notice
segmentals and suprasegmentals. This paper explores the intelligibility
judgments of same-L1 peers using P-Check (Version2, https://ver2.jp), a
Learning Management System (LMS) plug-in that aggregates peer feedback on
local intelligibility (Munro & Derwing, 2015). P-Check randomly delivers
written prompts for learners to record. Recordings are randomly delivered to
peers who choose from a drop-down menu which utterance was perceived.
Aggregated judgments from peers and from the instructor are displayed to
learners as feedback on intelligibility. This study used eight segmental
contrasts: /b-v/, /s-θ/, /l-ɹ/, /l-ɹ/-clusters, /æ-ʌ/, /ɑ-ʌ/, /ɑ-oʊ/, and
/i-ɪ/. Participants (N=38) made 3,451 intelligibility judgments on 1,203
recordings. The effects of rater listening discrimination proficiency and of
utterance intelligibility were examined in six contrasts using Generalized
Estimating Equations (GEE). Results showed that intelligibility was
generally a significant predictor of judgment accuracy, but rater listening
discrimination proficiency was not.
Learning to design a mobile hunt on Actionbound: a complex task?
Authors: Delforge Carole , Van de Vyver Julie , Meurice Alice
Published: November 2019

The research consisted in having an Actionbound mobile hunt for A1
learners of Dutch designed by a group of language Student Teachers (STs)
within the framework of a second year course on foreign language teaching.
The game was then implemented with two groups of fifth grade primary school
pupils during their visit of the Hergé Museum in Louvain-la-Neuve, Belgium.
These two steps allowed our multidisciplinary research team to analyse the
use of the app from the perspective of not only the players but also the
creators of the game. Research data was collected throughout the study via
questionnaires, observations, and a focus group. A qualitative analysis of
the STs’ data allowed us to establish their digital profiles, thereby
situating each of them in the digital integration process. The results
suggest that integrating technology and content when designing a pedagogical
activity is a complex task. Support and guidance from teacher trainers could
therefore be recommended in order to propose a pertinent integration of
technologies in the language classroom.
A case study of a learner’s use of an online translator as a cognitive
tool in a SCMC context
Authors: Domanchin Morgane
Published: November 2019

This study explores a language learner’s screen while interacting from a
desktop videoconferencing device as part of an intercultural
telecollaboration exchange that connected teacher-trainees and French
learners. Communicative tasks involving opinion exchanges require from
language learners simultaneous speaking and listening comprehension skills,
which may prompt linguistic difficulties. To compensate for their
weaknesses, learners had access to online resources exposing them to various
and complex language use. Based on Jonassen’s (1992) work on ‘cognitive
tools’ as intelligent resources that contribute to knowledge construction,
the author draws on multimodal interaction analysis to question the uses of
an automatic online translator in the context of Synchronous Computer
Mediated Communication (SCMC). This study illustrates a learner’s technical
autonomy using Google Translate (GT) to search for vocabulary while
interacting with his interlocutors. It reports the learner’s emergence of a
linguistic need which is followed by a search for vocabulary leading in some
cases to the searched translation’s integration within the pedagogical
interaction. This study raises cognitive challenges that such a practice
presents for language learning.
Social and Economic Empowerment for Village Women as a Strategy of Village Development
Authors: Kushandajani Kushandajani
Published: November 2019

The issuance of Law No. 6/2014 that is followed with the distribution of village fund has led the rise of program initiatives from village people. One of the crucial elements of development that needs for attention is social and economic development for women. Women's roles in these two areas are significant as compared to the other sectors like politics. Developing women in these two sectors is expected to encourage further development in the village. The research aims to identify the involvement of women in village development, in one village in Central Java, Lerep Village, Ungaran Barat District, Semarang Regency, through two domains: social and economic in 2017. This research is based on qualitative research using first-hand data collected from interviews with selected informants. This research used a case study as an approach and was focused on one village, namely Lerep, Semarang District, Central Java. In Lerep, we can see that the government have strived to a prioritized woman in their empowerment programs. The areas of development include health, education, domestic violence minimization, agriculture, entrepreneurship, and poverty reduction. As a result, women in Lerep could gain more income and enjoy some public facilities provided by the village government, which contribute to the improvement of woman health. In the future, there is a need to encourage woman empowerment as a framework for village development. Therefore, the advantage of the village fund will bring further impacts on society as a whole.
Strengthening Rural and Regional Economic Competitiveness Triggering Purworejo Regency Economic Growth through Tourism-Based Kutoarjo Transit Node Development
Authors: Triyani Ibtidah , Adam Khalid , Kristina Diana
Published: November 2019

The railway transport node in Kutoarjo, serving the southern route of Java, is an excellent opportunity for Kutoarjo's economic growth. Kutoarjo, located in the administrative area of Purworejo Regency in RTRW of Central Java Province belongs to Purwomanggung regional system covering Purworejo Regency, Wonosobo Regency, Magelang Regency, Magelang City, and Temanggung Regency. An international airport is also being built in Kulonprogo Regency, Special Region of Jogjakarta Province, which will be integrated with the existing stations in Purworejo Regency, explicitly located in Kutoarjo sub-district, Kutoarjo Station. The construction of NYIA (New Yogyakarta International Airport) in Kulon Progo is an excellent opportunity for the rise and trigger for Kutoarjo. However, the current condition of the existing Kutoharjo station is not optimal and does not significantly give added value to the economy either in Kutoarjo or Purworejo. Kutoharjo Station is only a temporary transit point, and there is no other object which can make visitors want to stop longer in Kutoharjo. This study aims to formulate a management development of Kutoarjo as a transit city that can contribute to mobilizing the economy in Purworejo Regency and its surrounding areas. The analysis is conducted by considering movement patterns, development of transit areas, supporting sectors and policies. Based on the analysis results, it can be seen that the development of transit area using seamless tourism concept requires ± 1.4 ha of land around Kutoarjo station, which is still included in 200 meters (walkable) radius. Result of study reveals that the development of node transit is supported by a potential tourism sector. The implication of this transit area development is the absorption of labor force in 2038 as many as 12,213 people. Besides, there is an economic increase of PAD (LGR) of 55.7% which eventually leads the LGR (PAD) reach IDR. 2.328.129.852.138 in 2039.
Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?
Authors: LaPointe Paul , Mercier Rebecca , Wolmarans Annemarie
Published: November 2019

Heat shock protein 90 (Hsp90) is a dimeric molecular chaperone that plays an essential role in cellular homeostasis. It functions in the context of a structurally dynamic ATP-dependent cycle to promote conformational changes in its clientele to aid stability, maturation, and activation. The client activation cycle is tightly regulated by a cohort of co-chaperone proteins that display specific binding preferences for certain conformations of Hsp90, guiding Hsp90 through its functional ATPase cycle. Aha-type co-chaperones are well-known to robustly stimulate the ATPase activity of Hsp90 but other roles in regulating the functional cycle are being revealed. In this review, we summarize the work done on the Aha-type co-chaperones since the 1990s and highlight recent discoveries with respect to the complexity of Hsp90 cycle regulation.
Developments in anticancer vaccination: budding new adjuvants
Authors: Santos-Sierra Sandra
Published: November 2019

The immune system has a limited capacity to recognize and fight cells that become cancerous and in cancer patients, the immune system has to seek the right balance between cancer rejection and host-immunosupression. The tumor milieu builds a protective shell and tumor cells rapidly accumulate mutations that promote antigen variability and immune-escape. Therapeutic vaccination of cancer is a promising strategy the success of which depends on a powerful activation of the cells of the adaptive immune system specific for tumor-cell detection and killing (e.g. CD4+ and CD8+ T-cells). In the last decades, the search for novel adjuvants that enhance dendritic cell (DC) function and their ability to prime T-cells has flourished and some Toll-like receptor (TLR) agonists have long been known to be valid immune adjuvants. The implementation of TLR-synthetic agonists in clinical studies of cancer vaccination is replacing the initial use of microbial-derived products with some encouraging results. The purpose of this review is to summarize the latest discoveries of TLR-synthetic agonists with adjuvant potential in anti-cancer vaccination.
Zoledronate-responsive calcitriol-mediated hypercalcemia in a 5-year-old case with squamous cell carcinoma on the background of xeroderma pigmentosum
Authors: Colak Ulkem , Mutlu Gul Y. , Sozmen Banu O. , Yucel Esra B. , Kayserili Hulya , Hatun Sukru
Published: November 2019

Malignancy-induced hypercalcemia is a very rare condition in children whereas it is more common among adult patients with malignancy. The mechanisms of malignancy-induced hypercalcemia include the over-secretion of parathyroid hormone-related protein (PTHrP), osteolytic metastases and the over-production of 1,25-dihydroxyvitamin D (calcitriol). Although hypercalcemia due to PTHrP secretion has been published before, overproduction of calcitriol has not been reported yet in pediatric squamous cell skin carcinoma cases. Herein, we report calcitriol-mediated severe hypercalcemia in a 5-year-old boy with squamous cell skin carcinoma arising in the background of xeroderma pigmentosum (XP) which responded well to zoledronate treatment. To the best of our knowledge, this is the first pediatric case of malignancy-induced hypercalcemia which is mediated by calcitriol in squamous cell skin carcinoma.
Ground state chemistry under vibrational strong coupling: dependence of thermodynamic parameters on the Rabi splitting energy
Authors: Thomas Anoop , Jayachandran Anjali , Lethuillier-Karl Lucas , Vergauwe Robrecht M.A. , Nagarajan Kalaivanan , Devaux Eloise , Genet Cyriaque , Moran Joseph , Ebbesen Thomas W.
Published: November 2019

Vibrational strong coupling (VSC) is currently emerging as a tool to control chemical dynamics. Here we study the impact of strong coupling strength, given by the Rabi splitting energy (ħΩR), on the thermodynamic parameters associated with the transition state of the desilylation reaction of the model molecule 1-phenyl-2-trimethylsilylacetylene. Under VSC, the enthalpy and entropy of activation determined from the temperature-dependent kinetic studies varied nonlinearly with the coupling strength. The thermodynamic parameters of the noncavity reaction did not show noticeable variation, ruling out concentration effects other than the enhanced ħΩR for the changes observed under VSC. The difference between the total free energy change under VSC and in noncavity was relatively smaller possibly because the enthalpy and entropy of activation compensate each other. This thermodynamic study gives more insight into the role of collective strong coupling on the transition state that leads to modified dynamics and branching ratios.
High Temperature Permanent Magnet Synchronous Machine Analysis of Thermal Field
Authors: Komeza Krzysztof , Lefik Marcin , Roger Daniel , Juszczak Ewa Napieralska , Elmadah Hamed , Napieralski Piotr , Takorabet Noureddine
Published: November 2019

The subject of the paper is a three-dimensional analysis of a coupled fluid-thermal and electromagnetic field in permanent magnet synchronous machine that can work at very high temperatures. To obtain the distribution of the airflow and temperature we employed the coupled fluid-thermal model of the machine. This allowed us to check whether the temperature in sensitive elements does not exceed the permissible limits. The analysis took into account the effect of the color and the smoothness of the machine housing on the temperature distribution in its interior. The influence of design on the temperature distribution and distribution of hot spots was tested. Two topologies are studied considering magnet mounted on the rotor surface or buried in the rotor soft magnetic core. The simulation results were compared with measurements made on a prototype.
Evaluation of the clinical chemistry tests analytical performance by using different models and specifications
Authors: Keleş Murat
Published: November 2019

Background

The importance of managing analytical quality in clinical laboratories is known. Goal-setting models are critical for analytical quality management, along with correctly implemented error models. However, the methods used to determine analytical performance and more importantly, the relevant analytical quality goals are open to discussion. Our aim was to compare the analytical performance characteristics of routine clinical chemistry tests with different goal-setting models which was proposed by various establishments. In addition, to provide a perspective to Turkish total analytical error (TAE) circular letter that compulsory to calculate from 2016.

Materials and methods

This study was performed by the data obtained from the internal and external quality control of clinical chemistry tests which were measured by Roche Cobas c501 biochemistry analyzer. TAE calculated with TAE% = 1.65 ×(CV%) + Bias% formula. Nordtest uncertainty model was used in the calculation of measurement uncertainty (MU). In this context, total analytical error was evaluated with biological variation (BV), RCPA, CLIA and Turkish allowable total error (ATE) goals. Measurement uncertainty was evaluated with only permissible measurement uncertainty (pU%) goal.

Results

In our study, RCPA goals are the most stringent, followed by the BVEuBIVAS, BVRicos, pU%, CLIA and finally the ATETurkey goals coming in last. In cumulatively, BVEuBIVAS goals were 18.3% lower than BVRicos for evaluated parameters.

Conclusion

The balance between applicability and analytical assurance of goals should be well ensured when determining goal-setting models. Circular letter (2016/18) creates awareness to the analytical quality management but still open to development. Biological variation dependent total allowable error model never designed to be used as benchmarks for measurement uncertainty and it is not methodologically appropriate for assessing measurement uncertainty which was estimated by the Nordtest method. Also considered that, the use of “permissible MU” is more methodologically appropriate in the evaluation of measurement uncertainty.
Metaheuristics Optimized Machine Learning Modelling of Environmental Exergo-Emissions for an Aero-Engine
Authors: Baklacioglu Tolga , Turan Onder , Aydin Hakan
Published: November 2019

The purpose of this study is to develop a metaheuristic design for primary parameters and architectures of two models of artificial neural network (ANN) in predicting a cargo aircraft’s exergo-emissions (exergy destruction ratio, rex,dest
, and waste exergy ratio, rwex
) at different flight stages. Hybrid genetic algorithm (GA)-ANN models have been accomplished utilizing real databases of rex,dest
and rwex
at various powers. Implementing a metaheuristics-based optimization on multilayer perceptron (MLP)-ANNs has produced the most favourable initial weights, step-size, biases, and training algorithm’s back-propagation (BP) momentum rate in addition to optimum number of neurons in the hidden layer(s). In accordance with an error assessment, a close fit linking real data and rwex
(linear correlation ratio, R, value of 0.999851) as well as rex,dest
(R value of 0.999985) predicted values is found. In the rex, dest
estimation model, the accuracy among single-hidden-layer networks has been confirmed to be higher; whereas, highly accurate testing outcomes have been obtained in two-hidden-layer networks as far as modeling of rwex
is concerned. ANN models’ optimization by GAs has increased the accuracy of the resulting models (R value of 0.999987 and 0.999869 for rex,dest
and rwex
, in that order ascertaining a drop-off in the testing stage errors).
Decidual small extracellular vesicles induce trophoblast invasion by upregulating N-cadherin
Authors: Liu Mian , Chen Xia , Chang Qing-Xian , Hua Rui , Wei Yan-Xing , Huang Li-Ping , Liao Yi-xin , Yue Xiao-Jing , Hu Hao-Yue , Sun Fei , Jiang Si-Jia , Quan Song , Yu Yan-Hong
Published: November 2019

Small extracellular vesicles (sEVs) are important mediators of cell-to-cell communication involved in the successful establishment of a pregnancy. Human decidual stromal cells play a key role in regulating trophoblast invasion. Nevertheless, the regulatory functions of decidual stromal cells-derived sEVs in human trophoblast cells are still unclear. In this study, primary human decidual stromal cells were isolated, and immortalized human endometrial stromal cell line (HESCs) were decidualized into human decidual stromal cells (HDSCs) using hormonal cocktail containing medroxy progesterone 17-acetate (MPA), estrogen and cAMP analog. HDSC-sEVs were isolated from both primary human decidual stromal cells and immortal HDSCs, respectively, and identified by transmission electron microscopy and western blotting. EV uptake assay indicated that HDSC-sEVs could be uptaken by trophoblast cells. HDSC-sEVs could increase the invasiveness and the expression level of N-cadherin of trophoblast cells with elevated phosphorylation of SMAD2 and SMAD3 in the cells. Silencing of N-cadherin could block cell invasion induced by HDSC-sEVs, while knockdown of SMAD2 and SMAD3 could inhibit the upregulation of N-cadherin in trophoblast cells. Taken together, our results suggested a regulatory effect of HDSC-sEVs in the invasion of trophoblast cells, and HDSC-sEVs may be important mediators of trophoblasts during embryo implantation and placentation.
Diş Hekimliği Eğitiminde Güncelleme: Eğitim ve Öğrenim Yöntemleri
Authors: AKALTAN Kadriye Funda
Published: November 2019

ÖZET

Lisans
diş hekimliği eğitimindeki hedefimiz; bir sonraki jenerasyonun yalnızca hastaların
konforu sağlayan ve beklentilerini gideren mezunlar değil, toplum ihtiyaçlarına
hizmet eden ve popülasyonun ağız sağlığını iyileştiren yetkin diş hekimleri
olmalarını sağlamaktır. Mezunların yaşam boyu öğrenmeye yönlendirilmesi,
yenilikçi ve geleneksel eğitim yöntemlerinin bir arada kullanılmasıyla eğitime
klinik gerçekliğin yansıtılması fakültelerin sorumluluğundadır. Önümüzdeki
yıllarda, akademik mükemmellik ölçülebilir ve elle tutulabilir terimler ile tarif
edilecektir. Sadece ünlü bir okul olmak yetmeyecek; eğitimde standartları
belirleyip yerine getirmeden, kalite değerlendirmelerini yapmak mümkün
olmayacaktır. Fakültelerin kendi koşulları için en uygun eğitim model/lerine
karar vermelerine ışık tutması beklenerek, bu derleme çalışmasında geleneksel
ve yenilikçi birçok eğitim ve öğrenim modeli sunulmaktadır.

Anahtar kelimeler: Diş
hekimliği eğitimi, yeterlik, öğrenme yöntemleri
Fakültenin Geliştirilmesi: Lisans Diş Hekimliği Eğitmenlerinin Görev ve Yeterlikleri
Authors: AKALTAN Kadriye Funda
Published: November 2019

Fakültelerin
geliştirilmesi; değişen öğrenim ve eğitim modelleri, mesleki uygulamalar ve
materyallerdeki sürekli gelişimin sonucu olarak kaçınılmazdır. Dental
eğitmenler lisans diş hekimliği eğitimine destek sağlayan önemli kişilerdir.
Eğitim ve öğretim başta olmak üzere, müfredat geliştirme gibi birçok görev ve
sorumluluğu üstlenirler. Bu makalede günümüz diş hekimliği fakülteleri için dental
eğitmenin görevleri ve iyi bir eğitmen olabilmeleri için gereken yeterlikleri
ile temel müfredat geliştirme aşamaları sunulmaktadır. Uzmanlık, doktora veya öğretim
üyesi ünvanlarını almak, kendiliğinden eğitim becerilerinin kazanılmasını
sağlamaz. Eğitmenler; sadece kendi öğretmenlerinin geçmişte kullandıkları
yöntemlere inandıklarında, eğitim gelişemeyecektir. Eğitimle ilgili
yeterliklerin öğrenilmesi ve geliştirilmesi gerekir. Eğitmenlerin sadece
öğretme, öğrenme, değerlendirme gibi mikro düzeydeki değil, müfredat gelişimi,
kurum, sağlık sistemi gibi alanlarda makro düzeydeki eğitim yeterliklerine de
ihtiyaçları vardır. Anahtar Kelimeler: Diş
hekimliği eğitimi, fakültenin
geliştirilmesi, eğitmen yeterlikleri, eğitmen görevleri
Psychological assessment in juvenile offenders: reliability and validity of Inventário de Jesness – revisado brasileiro
Authors: Costa Rafaelle Carolyne Santos , Komatsu André Vilela , De Oliveira Alana Batistuta Manzi , Bazon Marina Rezende
Published: November 2019

The Inventário de Jesness – revisado brasileiro (IJ-R-Br) assess psychological aspects of adolescent offenders. The objective of this study was to obtain evidence of reliability and criterion validity of two IJ-R-Br’s subscales. The responses of 928 male adolescents to the IJ-R-Br and the Questionário de Comportamento Juvenis (QCJ) were analyzed. Reliability was calculated by Cronbach’s alpha and Spearman- Brown coefficient. The criterion validity, through the Student’s t-test, of chi-squared and relative risk analysis, was used to verify the association between high scores on measures and high indicators of infractional engagement (measured by QCJ). The accuracy scores were unsatisfactory only for three of 12 Inventory scales. Regarding the criterion validity, there are more adolescents with high indicators of infractional engagement in the group with high scores. It is opportune to conduct research with a population of teenage offenders.
Purificando el cine en Costa Rica, 1936-1937: cruzada global, censura moral y movilización católica
Authors: Fernández Morera Esteban
Published: November 2019

La investigación estudia la censura católica de las exhibiciones cinematográficas en Costa Rica durante el periodo de 1936 a 1937. Se recurre a la prensa católica de la época para analizar el desarrollo de una campaña católica contra el “mal cine”, cuyas causas fueron producto de influencias globales aunadas con preocupaciones históricas locales. Los resultados de la investigación arrojaron, primero, la influencia de las movilizaciones provenientes de Estados Unidos y del Vaticano en la campaña católica contra el cine “inmoral” en Costa Rica. Segundo, se muestra cómo la réplica de la campaña católica internacional contra el cine fue posible gracias a las críticas moralistas locales efectuadas históricamente hacia el nuevo entretenimiento público. Tercero, se abordan las diversas estrategias de la campaña costarricense para censurar los contenidos “inmorales” de las películas. Finalmente, se realizará un balance de los logros y fracasos de tal maniobra, permitiendo una reflexión sobre los alcances culturales del cine en la sociedad costarricense del periodo.
JINĀS DALAM KITAB FATHUL MU’IN KARYA AHMAD ZAINUDDIN ALFANNANI BAB (SHALAT, ZAKAT, PUASA, HAJI DAN UMRAH, JUAL BELI, DAN IJARAH) (KAJIAN ILMU BADĪ)
Authors: Qodariyah Putri Fatimah , Halim Muhamad Abdul , Nurlinah Nurlinah
Published: November 2019

This research departs from the fact that the previous books contained many beauties, both in terms of lafadz and meaning. The Fathul Mu'in Book is one of the books written by Ahmad Zainuddin Alfannani, this book discusses the jurisprudence in this book is quite complete covering the chapter thaharah for jinayat or law. The book Fathul Mu'in is one of the books which is more the beauty of language in it, namely jin. Jinn language is the likeness of two lafadz in pronunciation, but the meaning is different. In this study discuss the analysis contained in the Book of Fathul Mu'in, and based on this background, the research is formulated as follows: 1) What is included in the Book of Fathul Mu'in by Ahmad Zainuddin Alfannani Chapter (Prayer, Zakat, Fasting) , Hajj and Umrah, buying and selling, and ijarah) The work of Ahmad Zainuddin Alfannani, 2) Any form of Jinapa which is included in the Book of Fathul Mu'in by Ahmad Zainuddin Alfannani Chapter (Prayer, Zakat, Fasting, Hajj and Umrah, buying and selling, and ijarah) The work of Ahmad Zainuddin Alfannani. This study uses descriptive analysis method, descriptive analysis method is done by describing the facts then followed by analysis. The descriptive method of analysis is not only eye-breaking, but also provides sufficient understanding and explanation of jinās in the Fathul Mu'in book by understanding Balāghah.            After conducting the research, the researcher draws the results of the analysis, that the types and forms of Jinās contained in the Fathul Mu'in Chapter (Prayer, Zakat, Hajj and Umrah, buying and selling, ijarah) by Ahmad Zainuddin Bin Abdul Aziz Alfannani are: types Jinās, numbering 87 kinds of Jinās, which includes 7 types of Jinās, namely Jinās tām mumāsil, Jinās tām mustaufi, Jinās ghair tām naqis mudhōri ', Jinās tām, Jinās ghair tām naqis lāhi), Jinās ghair tām qolab kul, and Jinās ghair tām qolab ba'di kulk, and Form Jinās, totaling 145 forms, which consist of fi'il (verb) and isim (noun) arrangement. The fiil is fi'il Mādi and Fi'il Mudōri. The isim in the book is masdar isim, isim fa'il isim maf'ul and isim jamid.
The role of video-assisted feedback sessions in resident teaching: A pre-post intervention
Authors: Tran Allen , Vertes Jaclyn , Kulai Tasha , Connors Lori
Published: November 2019

This article was migrated. The article was marked as recommended. Purpose: Despite providing a large component of teaching to trainees, internal medicine residents receive little feedback on their teaching ability. Methods: This was a single-center, mixed methods study of 19 senior internal medicine residents in Canada. Classroom-based teaching sessions delivered by the participants were individually video recorded. The individual recording was then watched by the participant and by two feedback facilitators, who then met for face-to-face feedback. Participants completed a self-reflective exercise after this intervention. Audience members of the recorded session and a post-feedback teaching session completed an evaluation form. Scores from the evaluation forms from each phase were analyzed with the Wilcoxon Signed-Rank Test. Inductive coding was performed for qualitative data from the feedback sessions and reflective exercises. Results: 19 residents participated. There was no statistical difference in the evaluation form scores between the pre-intervention and post-intervention teaching sessions. Mean scores varied from 4.6 to 5.0 out of 5.0 on combined pre-and post-intervention evaluations. 89% of participants found viewing their recorded session useful. 94% of residents stated the intervention was worth continuing. Common themes of feedback and self-evaluation included "time-management," "organization," "communication," and "environment." Conclusion: Video-assisted feedback of teaching improved self-perception of a resident's teaching ability.
Access to Novel Drugs for Non-Small Cell Lung Cancer in Central and Southeastern Europe: A Central European Cooperative Oncology Group Analysis
Authors: Cufer Tanja , Ciuleanu Tudor E. , Berzinec Peter , Galffy Gabriela , Jakopovic Marko , Jassem Jacek , Jovanovic Dragana , Mihaylova Zhasmina , Ostoros Gyula , Thallinger Christiane , Zemanova Milada , Zielinski Christoph
Published: November 2019

Background

Treatment of non-small cell lung cancer (NSCLC) improved substantially in the last decades. Novel targeted and immune-oncologic drugs were introduced into routine treatment. Despite accelerated development and subsequent drug registrations by the European Medicinal Agency (EMA), novel drugs for NSCLC are poorly accessible in Central and Eastern European (CEE) countries.

Material and Methods

The Central European Cooperative Oncology Group conducted a survey among experts from 10 CEE countries to provide an overview on the availability of novel drugs for NSCLC and time from registration to reimbursement decision in their countries.

Results

Although first-generation epidermal growth factor receptor tyrosine kinase inhibitors were reimbursed and available in all countries, for other registered therapies—even for ALK inhibitors and checkpoint inhibitors in first-line—there were apparent gaps in availability and/or reimbursement. There was a trend for better availability of drugs with longer time from EMA marketing authorization. Substantial differences in access to novel drugs among CEE countries were observed. In general, the availability of drugs is not in accordance with the Magnitude of Clinical Benefit Scale (MCBS), as defined by the European Society for Medical Oncology (ESMO). Time spans between drug registrations and national decisions on reimbursement vary greatly, from less than 3 months in one country to more than 1 year in the majority of countries.

Conclusion

The access to novel drugs for NSCLC in CEE countries is suboptimal. To enable access to the most effective compounds within the shortest possible time, reimbursement decisions should be faster and ESMO MCBS should be incorporated into decision making.
Blood-Based Next-Generation Sequencing Analysis of Appendiceal Cancers
Authors: Shaib Walid L. , Zakka Katerina , Staley Charles , Roberts Ali , Akce Mehmet , Wu Christina , Alese Olatunji B. , El-Rayes Bassel F.
Published: November 2019

Background

Appendiceal cancers (ACs) are rare. The genomic landscape of ACs has not been well studied. The aim of this study was to confirm the feasibility of next-generation sequencing (NGS) using circulating tumor DNA (ctDNA) in ACs and characterize common genomic alterations.

Materials and Methods

Molecular alterations in 372 plasma samples from 303 patients with AC using clinical-grade NGS of ctDNA (Guardant360) across multiple institutions were evaluated. Test detects single nucleotide variants in 54–73 genes, copy number amplifications, fusions, and indels in selected genes.

Results

A total of 303 patients with AC were evaluated, of which 169 (56%) were female. Median age was 56.8 (25–83) years. ctDNA NGS testing was performed on 372 plasma samples; 48 patients had testing performed twice, 9 patients had testing performed three times, and 1 patient had testing performed four times. Genomic alterations were defined in 207 (n = 207/372, 55.6%) samples, and 288 alterations were identified excluding variants of uncertain significance and synonymous mutations. Alterations were identified in at least one sample from 184 patients; TP53-associated genes (n = 71, 38.6%), KRAS (n = 33, 17.9%), APC (n = 14, 7.6%), EGFR (n = 12, 6.5%), BRAF (n = 11, 5.9%), NF1 (n = 10, 5.4%), MYC (n = 9, 4.9%), GNAS (n = 8, 4.3%), MET (n = 6, 3.3%), PIK3CA (n = 5, 2.7%), and ATM (n = 5, 2.7%). Other low-frequency but clinically relevant genomic alterations were as follows: AR (n = 4, 2.2%), TERT (n = 4, 2.2%), ERBB2 (n = 4, 2.2%), SMAD4 (n = 3, 1.6%), CDK4 (n = 2, 1.1%), NRAS (n = 2, 1.1%), FGFR1 (n = 2, 1.1%), FGFR2 (n = 2, 1.1%), PTEN (n = 2, 1.1%), RB1 (n = 2, 1.1%), and CDK6, CDKN2A, BRCA1, BRCA2, JAK2, IDH2, MAPK, NTRK1, CDH1, ARID1A, and PDGFRA (n = 1, 0.5%).

Conclusion

Evaluation of ctDNA is feasible among patients with AC. The frequency of genomic alterations is similar to that previously reported in tissue NGS. Liquid biopsies are not invasive and can provide personalized options for targeted therapies in patients with AC.

Implications for Practice

The complexity of appendiceal cancer and its unique genomic characteristics suggest that customized combination therapy may be required for many patients. Theoretically, as more oncogenic pathways are discovered and more targeted therapies are approved, customized treatment based on the patient's unique molecular profile will lead to personalized care and improve patient outcomes. Liquid biopsies are noninvasive, cost-effective, and promising methods that provide patients with access to personalized treatment.
Design and construction of a sprayed-concrete-lined quarry tunnel in the UK
Authors: Thorpe William
Published: November 2019

Southam quarry in Warwickshire, UK, supplies clay and limestone to a nearby cement works in Rugby. A new conveyor tunnel completed in 2017 will ensure its continued operation for a further 28 years. The 60 m long, sprayed-concrete-lined tunnel under the A426 highway houses part of a new 1 km long conveyor system that now transports 2500 t/day of quarried material to the processing plant. Construction of the tunnel was undertaken in a busy quarry environment and under a live highway. The design and construction of the tunnel and its two engineered portals are described in this paper.
Сharacterization of copper-nickel mineralization of metagabbroids (North Timan)
Authors: Шмакова Александра
Published: November 2019

The article discusses the comparison of the mineralogical and technological properties of minerals and the whole copper-nickel ore manifestations of the "Blizhneye" and "Dal'neye" Bugrovskaya area. According to the results of the study, rock-forming and secondary minerals of ore-bearing rocks were established. Characterized sulfide minerals and their associations. In general, the complexity of ores, including precious metal mineralization, was noted. According to the obtained mineralogical data, possible methods of ore enrichment are predicted.
Analysis of fluid inclusions in vein quartz of the Fenkina-Lampi deposit by gas chromatography
Authors: Светова Евгения , Шанина Светлана
Published: November 2019

The composition and content of fluid inclusions in the main structural and technological types of vein quartz of the Fenkina-Lampi deposit were studied by gas chromatography. It is shown that H2O dominates (90–99%) in the gases composition released from quartz under heating to 1000°C, CO2, CO, N2 and hydrocarbon compounds contents are much less. Quartz is characterized by high gassing in the high-temperature region (600–1000°C) comparable to gassing in the low-temperature interval (100–600°C), which is a negative indicator of the quality of quartz as a raw material for high-quality glass melting. It is necessary to develop a special purification technology for this quartz, which will take into account the features of its saturation with gas-liquid inclusions.
Artificial waste as a new source of non-ferrous, noble, rare and toxic metals of Almalyk mining and metallurgical combine
Authors: Туресебеков Арпай , Шукуров Носир , Шарипов Хасан , Алабергенов Роман , Зунунов Абдували , Шукуров Шухрат
Published: November 2019

The results of the integrated study of metal waste from Almalyk Mining-Metallurgical Plant (AMMP) are reported. Non-ferrous, noble and rare-metal reserves in waste from the dressing and metallurgical conversion of copper-molybdenum and lead-zinc deposits were evaluated. Analysis of the chemical composition and distribution of non-ferrous, noble, rare and toxic metals and their mode of occurrence in artificial waste from AMMP has shown that they are highly complex ores which could be used to increase metal production at AMMP.
Heterologous protein expression in E. coli v3
Authors: R Ganguly Diep , Rhodes Timothy , Chi Khin Nay , E Tee Estee , Xun Chan Kai
Published: November 2019

Protocol for recombinant protein expression in E. coli for protein purification and subsequent enzyme assays, protein crystallography etc.
Evaluation of the Implementation of the Universal Basic Education Yoruba Language Curriculum in South Western Nigeria
Authors: Ayo AYODELE Christiana , Oludele OYINLOYE Gabriel
Published: November 2019

The study evaluated the implementation of the Universal Basic Education Yoruba Language Curriculum in South Western States of Nigeria. The purpose is to determine the extent of the coverage of the Curriculum. It is also meant to determine whether the objectives of the Yoruba Language Curriculum are achieved. Also, it is meant to ascertain the attitude of the students towards the learning of Yoruba Language. The study is a descriptive research of the survey design. The population consists of all students and teachers that are teaching Yoruba Language in all upper Basic Schools in South Western Nigeria. A sample of 1500 respondents which consists of 1200 students and 300 teachers that are teaching Yoruba Language in upper Basic Schools was selected through the use of multistage sampling techniques. Three (3) Research questions and (2) Two Hypotheses were used and tested at 0.5 level of significance. Four instruments were used to elicit information. They are, Teachers’ Questionnaire on implementation of the Universal Basic Education Yoruba Language Curriculum, Questionnaire on students’ attitude towards learning of Yoruba language and Students achievement test. The students’ class notes were also used to know the extent of the work done. The data generated were subjected to descriptive analysis and inferential statistics. The findings revealed that, there was a low positive relationship between the Universal Basic Education Yoruba Language Curriculum and its implementation.