bluuebunny/crossref_metadata_2025 huggingface dataset:
Service Provider Perspectives on the Differences between Place‐Based and Scattered‐Site Permanent Supportive Housing in Los Angeles County after the Onset of the COVID‐19 Pandemic
Authors: Padwa Howard , Tran Smith Bikki , Harris Taylor , Ijadi-Maghsoodi Roya , Cooper Madelyn , Loya Carissa , Kuhn Randall , Henwood Benjamin F. , Gelberg Lillian
Published: July 2024

Background. Permanent supportive housing (PSH) is an evidence‐based solution to chronic homelessness. There are two common PSH models: place‐based (PB) programs where clients live in one building with services provided onsite and scattered‐site (SS) programs, which use community apartments coupled with mobile case management and support. Understanding the relative strengths and weaknesses of PB and SS is important for PSH planning and service delivery. This paper explores homeless service provider perspectives on these two models after the onset of the COVID‐19 pandemic. Methods. Service providers (N = 37) from across 5 PSH agencies in Los Angeles that provided either PB or SS services during the pandemic participated in focus groups. Discussions were recorded, transcribed, and analyzed using template analysis, grounded theory, and inductive techniques. Results. Providers identified four major differences between PB and SS services: (1) challenges in finding placements; (2) managing relationships with landlords/property managers; (3) frequency of contact; and (4) community integration. Advantages of PB included ease of finding units, ease of managing relationships with landlords/property managers, greater ability to serve clients efficiently, more frequent client contact, and more community among residents. SS was seen to provide tenants with more opportunities to grow, live in healthier environments, and develop independence. During the pandemic, finding units for SS clients became more difficult, while differences between PB and SS related to frequency of contact and community integration became more attenuated. Conclusions. PB can be advantageous for clients with higher levels of acuity, whereas SS could be more appropriate for clients who are more stable and independent. PB programs are seen to have practical and logistical advantages, but some providers prefer SS services. Clients and providers should be matched to PSH configurations that best match their needs and preferences, and providers should be aware that public health emergencies may impact PB and SS settings differently.
Evaluating Growth Patterns and Soil Dynamics of the Endangered African Rosewood (Pterocarpus erinaceusPoir.) in Contrasting Ecological Regions in Ghana
Authors: Asigbaase Michael , Adusu Daniel , Sarfo Daniel Akoto , Nsor Collins Ayine , Kumi Samuel , Adams Seidu , Nsiah Paul Kofi , Acheamfour Selina Adutwumwaa
Published: July 2024

Pterocarpus erinaceus(Poir.) is an endemic and endangered species of the Guinea‐Sudano‐Sahelian​ zones currently overexploited for timber, fodder, and medicinal purposes. Therefore, plantations are critical to meeting the high demand in the international market while reducing pressure on natural stands, but its growth performance across different ecological zones is not well documented. Thus, we assessed the influence of ecological zones and soil properties on the survival and growth performance ofP. erinaceus. Data were collected from 12 subplots ofP. erinaceusstands in the Dry Semi‐Deciduous Fire Zone (DSFZ) and 16 subplots in the Moist Semi‐Deciduous North West Zone (MSNW). We assessed the survival and growth performance ofP. erinaceususing one‐way ANOVA, variation in soil properties using the Generalized Linear Model, and the influence of soil properties onP. erinaceusgrowth characteristics via correlation analysis. We found that the percentage survival ofP. erinaceuswas similar in both ecological zones. However,P. erinaceusdemonstrated a high level of variation in growth attributes, growing taller with deeper canopies in wetter conditions and larger crown spread in drier conditions. The aboveground biomass carbon stocks ofP. erinaceusstands were similar in both ecological zones, highlighting the potential role of the species as a carbon sink in the ecological zones. Soil organic matter, nitrogen, and calcium contents were higher in soils of the MSNW stands than those of the DSFZ stands. However, potassium, magnesium, sodium, and phosphorus contents were stable across the ecological zones. We concluded that wetter conditions enhance the growth performance ofP. erinaceusas a timber species.
Supplementary Table S6 from CD106 in Tumor-Specific Exhausted CD8+ T Cells Mediates Immunosuppression by Inhibiting TCR Signaling
Authors: Naoi Yuto , Morinaga Takao , Nagasaki Joji , Ariyasu Ryo , Ueda Youki , Yamashita Kazuo , Zhou Wenhao , Kawashima Shusuke , Kawase Katsushige , Honobe-Tabuchi Akiko , Ohnuma Takehiro , Kawamura Tatsuyoshi , Umeda Yoshiyasu , Kawahara Yu , Nakamura Yasuhiro , Kiniwa Yukiko , Yamasaki Osamu , Fukushima Satoshi , Kawazu Masahito , Suzuki Yutaka , Nishikawa Hiroyoshi , Hanazawa Toyoyuki , Ando Mizuo , Inozume Takashi , Togashi Yosuke
Published: July 2024

Differentially expressed genes between the exhausted CD8+ T cells and the others
Figure S5 from A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
Authors: White Brian S. , Woo Xing Yi , Koc Soner , Sheridan Todd , Neuhauser Steven B. , Wang Shidan , Evrard Yvonne A. , Chen Li , Foroughi pour Ali , Landua John D. , Mashl R. Jay , Davies Sherri R. , Fang Bingliang , Rosa Maria Gabriela , Evans Kurt W. , Bailey Matthew H. , Chen Yeqing , Xiao Min , Rubinstein Jill C. , Sanderson Brian J. , Lloyd Michael W. , Domanskyi Sergii , Dobrolecki Lacey E. , Fujita Maihi , Fujimoto Junya , Xiao Guanghua , Fields Ryan C. , Mudd Jacqueline L. , Xu Xiaowei , Hollingshead Melinda G. , Jiwani Shahanawaz , Acevedo Saul , Davis-Dusenbery Brandi N. , Robinson Peter N. , Moscow Jeffrey A. , Doroshow James H. , Mitsiades Nicholas , Kaochar Salma , Pan Chong-xian , Carvajal-Carmona Luis G. , Welm Alana L. , Welm Bryan E. , Govindan Ramaswamy , Li Shunqiang , Davies Michael A. , Roth Jack A. , Meric-Bernstam Funda , Xie Yang , Herlyn Meenhard , Ding Li , Lewis Michael T. , Bult Carol J. , Dean Dennis A. , Chuang Jeffrey H.
Published: July 2024

Figure S5
Figure S3 from A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
Authors: White Brian S. , Woo Xing Yi , Koc Soner , Sheridan Todd , Neuhauser Steven B. , Wang Shidan , Evrard Yvonne A. , Chen Li , Foroughi pour Ali , Landua John D. , Mashl R. Jay , Davies Sherri R. , Fang Bingliang , Rosa Maria Gabriela , Evans Kurt W. , Bailey Matthew H. , Chen Yeqing , Xiao Min , Rubinstein Jill C. , Sanderson Brian J. , Lloyd Michael W. , Domanskyi Sergii , Dobrolecki Lacey E. , Fujita Maihi , Fujimoto Junya , Xiao Guanghua , Fields Ryan C. , Mudd Jacqueline L. , Xu Xiaowei , Hollingshead Melinda G. , Jiwani Shahanawaz , Acevedo Saul , Davis-Dusenbery Brandi N. , Robinson Peter N. , Moscow Jeffrey A. , Doroshow James H. , Mitsiades Nicholas , Kaochar Salma , Pan Chong-xian , Carvajal-Carmona Luis G. , Welm Alana L. , Welm Bryan E. , Govindan Ramaswamy , Li Shunqiang , Davies Michael A. , Roth Jack A. , Meric-Bernstam Funda , Xie Yang , Herlyn Meenhard , Ding Li , Lewis Michael T. , Bult Carol J. , Dean Dennis A. , Chuang Jeffrey H.
Published: July 2024

Figure S3
Figure S3 from Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer
Authors: Yang Sheng , Zhang Dongsheng , Sun Qingyang , Nie Hongxu , Zhang Yue , Wang Xiaowei , Huang Yuanjian , Sun Yueming
Published: July 2024

Figure S3. Potential functions of CXCL1+ CAFs and SFRP2+ CAFs. (A, B) Dot plot displaying GO analysis of CXCL1+ CAFs and SFRP2+ CAFs.
Differentially regulated lipids from GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma
Authors: Wang Dazhi , Mahmud Iqbal , Thakur Vijay S. , Tan Sze Kiat , Isom Daniel G. , Lombard David B. , Gonzalgo Mark L. , Kryvenko Oleksandr N. , Lorenzi Philip L. , Tcheuyap Vanina T. , Brugarolas James , Welford Scott M.
Published: July 2024

Differentially regulated lipids
Supplementary Tables from Comprehensive Genetic Profiling Reveals Frequent Alterations of Driver Genes on the X Chromosome in Extranodal NK/T-cell Lymphoma
Authors: Ito Yuta , Marouf Amira , Kogure Yasunori , Koya Junji , Liévin Raphaël , Bruneau Julie , Tabata Mariko , Saito Yuki , Shingaki Sumito , Yuasa Mitsuhiro , Yamaguchi Kentaro , Murakami Koichi , Weil Robert , Vavasseur Manon , Andrieu Guillaume P. , Latiri Mehdi , Veleanu Layla , Dussiot Michaël , André Isabelle , Joshi Akshay , Lagresle-Peyrou Chantal , Magerus Aude , Chaubard Sammara , Lavergne David , Bachy Emmanuel , Brunet Erika , Fataccioli Virginie , Brouzes Chantal , Laurent Camille , de Leval Laurence , Traverse-Glehen Alexandra , Bossard Céline , Parrens Marie , Meignin Véronique , Philippe Laure , Rossignol Julien , Suarez Felipe , Michot Jean-Marie , Tournilhac Olivier , Damaj Gandhi , Lemonnier François , Bôle-Feysot Christine , Nitschké Patrick , Tesson Bruno , Laurent Cécile , Molina Thierry , Asnafi Vahid , Watatani Yosaku , Chiba Kenichi , Okada Ai , Shiraishi Yuichi , Tsukita Sachiko , Izutsu Koji , Miyoshi Hiroaki , Ohshima Koichi , Sakata Seiji , Dobashi Akito , Takeuchi Kengo , Sanada Masashi , Gaulard Philippe , Jaccard Arnaud , Ogawa Seishi , Hermine Olivier , Kataoka Keisuke , Couronné Lucile
Published: July 2024

Supplementary Tables S1-S24
Figure S6 from Omental Preadipocytes Stimulate Matrix Remodeling and IGF Signaling to Support Ovarian Cancer Metastasis
Authors: Waters Jennifer A. , Robinson Mikella , Lujano-Olazaba Omar , Lucht Cassidy , Gilbert Samuel F. , House Carrie D.
Published: July 2024

PCA and GSEA
Figure S4 from Omental Preadipocytes Stimulate Matrix Remodeling and IGF Signaling to Support Ovarian Cancer Metastasis
Authors: Waters Jennifer A. , Robinson Mikella , Lujano-Olazaba Omar , Lucht Cassidy , Gilbert Samuel F. , House Carrie D.
Published: July 2024

Analysis of classic TIC markers
Data from The circMYBL2-Encoded p185 Protein Suppresses Colorectal Cancer Progression by Inhibiting Serine Biosynthesis
Authors: Zhao Ning , Cao Yinghao , Tao Ruikang , Zhu Xiuxian , Li Runze , Chen Yajun , Tao Kaixiong , Li Lei , Chen Hengyu , Ma Xianxiong
Published: July 2024

Abstract
Circular RNAs are a class of covalently closed single-stranded loop RNAs that have been implicated to play a functional role in almost all types of cancers. Previous studies have revealed that circMYBL2 acts as a tumor-promoting circular RNA. In this study, we found that circMYBL2 in colorectal cancer encodes a 185-amino acid protein, p185. Functionally, circMYBL2-encoded p185 suppressed the growth and aggressiveness of colorectal cancer cells in vitro and in vivo. Mechanistically, p185 counteracted ubiquitin C-terminal hydrolase L3 (UCHL3)–mediated deubiquitination of phosphoglycerate dehydrogenase (PHGDH) by competitively binding to the C1 domain of UCHL3, resulting in PHGDH degradation and a subsequent reduction in serine and glycine biosynthesis. These data revealed that the circMYBL2-encoded p185 isoform serves as a tumor suppressor to inhibit the progression of colorectal cancer by reducing serine biosynthesis.

Significance: A p185 protein encoded by circMYBL2 functions as a tumor suppressor that inhibits the progression of colorectal cancer by increasing the degradation of PHGDH to reduce serine biosynthesis.
Supplementary Figure S4 from Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts Using a Humanized Anti-Fibroblast Activation Protein Antibody
Authors: Kobayashi Teruki , Noma Kazuhiro , Nishimura Seitaro , Kato Takuya , Nishiwaki Noriyuki , Ohara Toshiaki , Kunitomo Tomoyoshi , Kawasaki Kento , Akai Masaaki , Komoto Satoshi , Kashima Hajime , Kikuchi Satoru , Tazawa Hiroshi , Shirakawa Yasuhiro , Choyke Peter L. , Kobayashi Hisataka , Fujiwara Toshiyoshi
Published: July 2024

Supplementary Figure S4
Supplementary Figure 5 from Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma
Authors: Plotnik Joshua P. , Richardson Adam E. , Yang Haopeng , Rojas Estela , Bontcheva Velitchka , Dowell Colleen , Parsons Sydney , Wilson Ashley , Ravanmehr Vida , Will Christine , Jung Paul , Zhu Haizhong , Partha Sarathy Karunan , Panchal Sanjay C. , Mali Raghuveer Singh , Kohlhapp Frederick J. , McClure Ryan A. , Ramathal Cyril Y. , George Mariam D. , Jhala Manisha , Elsen Nathaniel L. , Qiu Wei , Judge Russell A. , Pan Chin , Mastracchio Anthony , Henderson Jared , Meulbroek Jonathan A. , Green Michael R. , Pappano William N.
Published: July 2024

Antiapoptotic complex formation in ABC-DLBCL xenografts after ABBV-MALT1 monotherapy
Supplementary Figure S6 from The Novel ATR Inhibitor M1774 Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Authors: Jo Ukhyun , Arakawa Yasuhiro , Zimmermann Astrid , Taniyama Daiki , Mizunuma Makito , Jenkins Lisa M. , Maity Tapan , Kumar Suresh , Zenke Frank T. , Takebe Naoko , Pommier Yves
Published: July 2024

This figure shows representative images in the treatment of TPT (topotecan) and M1774 in small cell lung cancer organoids, and profiling of cell viability and DNA-damage molecules after drug treatment.
Movie S1 from Optimizing the Design and Geometry of T Cell–Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer
Authors: Elsayed Abdullah , Plüss Louis , Nideroest Larissa , Rotta Giulia , Thoma Marina , Zangger Nathan , Peissert Frederik , Pfister Stefanie K. , Pellegrino Christian , Dakhel Plaza Sheila , De Luca Roberto , Manz Markus G. , Oxenius Annette , Puca Emanuele , Halin Cornelia , Neri Dario
Published: July 2024

Supplementary Movie1
Supplementary Figure 7 from Ultrasensitive Response Explains the Benefit of Combination Chemotherapy Despite Drug Antagonism
Authors: Patterson Sarah C. , Pomeroy Amy E. , Palmer Adam C.
Published: July 2024

Supplemental Figure 7. Previously published CRISPR inhibition (A) and CRISPR activation (B) data shows log-normally distributed drug sensitivities across a heterogeneous tumor cell population. When heritable heterogeneity was induced via CRISPR inhibition or activation, cell populations had log-normally distributed sensitivities. A) Genome-wide CRISPR inhibition screen was performed in dCas9-KRAB expressing Pfeiffer cells (diffuse large B-cell lymphoma) treated with single agent rituximab (R), 4-H-cyclophosphamide (C), doxorubicin (H), and vincristine (O). B) Genome-wide CRISPR activation screen was performed in dCas9-VP64 expressing K562 cells (chronic myeloid leukemia) and treated with single agent 4-H-cyclophosphamide (C), doxorubicin (H), and vincristine (O). Data publicly available from Palmer et al. eLife (2019)9.
Supplementary Figure S1 from Distinct Regulation of ASCL1 by the Cell Cycle and Chemotherapy in Small Cell Lung Cancer
Authors: Liu Yuning , Wu Qingzhe , Jiang Bin , Hou Tingting , Wu Chuanqiang , Wu Ming , Song Hai
Published: July 2024

Supplementary Figure S1. ASCL1 protein level is regulated by the cell cycle.
Supplementary Figure S5 from Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth
Authors: Muthukrishnan Sree Deepthi , Qi Haocheng , Wang David , Elahi Lubayna , Pham Amy , Alvarado Alvaro G. , Li Tie , Gao Fuying , Kawaguchi Riki , Lai Albert , Kornblum Harley I.
Published: July 2024

Supplementary Figure S5. ASPN expression is enriched in IDH mutant LGG and regulated by D-2HG
Supplementary Materials and Methods from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3
Authors: Ebegboni Vernon Justice , Jones Tamara L. , Brownmiller Tayvia , Zhao Patrick X. , Pehrsson Erica C. , Sundara Rajan Soumya , Caplen Natasha J.
Published: July 2024

Supplementary Materials and Methods - RNA sequencing, Chromatin Immunoprecipitation (ChIP) and CUT&RUN analysis, Immunoblotting and Immunofluorescence
Supplementary Figure S7 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3
Authors: Ebegboni Vernon Justice , Jones Tamara L. , Brownmiller Tayvia , Zhao Patrick X. , Pehrsson Erica C. , Sundara Rajan Soumya , Caplen Natasha J.
Published: July 2024

Depletion of TNS3 in EWS cells expressing ETS1 results in changes in the distribution of vinculin and F-actin
Supplementary Figure S5 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3
Authors: Ebegboni Vernon Justice , Jones Tamara L. , Brownmiller Tayvia , Zhao Patrick X. , Pehrsson Erica C. , Sundara Rajan Soumya , Caplen Natasha J.
Published: July 2024

EWS cells expressing ETS1 exhibit TENSIN3-dependent changes in the organization of vinculin
Supplementary Figure S6 from Vasorin Exocytosed from Glioma Cells Facilitates Angiogenesis via VEGFR2/AKT Signaling Pathway
Authors: Zhong Ying , Kang Hui , Ma Ziqing , Li Jiayu , Qin Zixi , Zhang Zixuan , Li Peiwen , Zhong Ying , Wang Lihui
Published: July 2024

VASN promotes tip cell phenotype transformation in HUVECs by activatingVEGFR2 in a VEGFA-independent manner
Supplementary Figure S5 from Vasorin Exocytosed from Glioma Cells Facilitates Angiogenesis via VEGFR2/AKT Signaling Pathway
Authors: Zhong Ying , Kang Hui , Ma Ziqing , Li Jiayu , Qin Zixi , Zhang Zixuan , Li Peiwen , Zhong Ying , Wang Lihui
Published: July 2024

Correlation between VASN expression and the percentage of CD31+CD34+ / CD31+ blood vessels in clinical glioma tissues
Supplementary Fig. S1 from Small Extracellular Vesicle piR-hsa-30937 Derived from Pancreatic Neuroendocrine Neoplasms Upregulates CD276 in Macrophages to Promote Immune Evasion
Authors: Zhong Yuan , Tian Ye , Wang Yan , Bai Jian’an , Long Qin , Yan Lijun , Gong Zhihui , Gao Wei , Tang Qiyun
Published: July 2024

Supplementary Fig. S1 PNEN cell-derived sEVs drive CD276 expression in human monocyte-derived macrophages (hMDMs) to inhibit T-cell immunity.
Supplementary Figure S17 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Fig. S17. TAA expression analysis on AML PDX cells.
Supplementary Figure 8 from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Fig.S8. SIRT3 deficiency promotes TFH cell differentiation after PR8 infection.
Supplementary Figure 9 from PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell–Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors
Authors: Alteber Zoya , Cojocaru Gady , Granit Roy Z. , Barbiro Inbal , Wool Assaf , Frenkel Masha , Novik Amit , Shuchami Adi , Liang Yu , Carmi Vered D. , Sabath Niv , Foreman Rob , Petrenko Natalia , He Jiang , Kliger Yossef , Levy-Barda Adva , Eitan Ram , Raban Oded , Sadot Eran , Sulimani Omri , Nathan Abraham Avi , Adewoye Henry , Ferre Pierre , Levine Zurit , Ophir Eran
Published: July 2024

Supplementary Figure 9
Supplementary Figure 7 from PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell–Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors
Authors: Alteber Zoya , Cojocaru Gady , Granit Roy Z. , Barbiro Inbal , Wool Assaf , Frenkel Masha , Novik Amit , Shuchami Adi , Liang Yu , Carmi Vered D. , Sabath Niv , Foreman Rob , Petrenko Natalia , He Jiang , Kliger Yossef , Levy-Barda Adva , Eitan Ram , Raban Oded , Sadot Eran , Sulimani Omri , Nathan Abraham Avi , Adewoye Henry , Ferre Pierre , Levine Zurit , Ophir Eran
Published: July 2024

Supplementary Figure 7
Supplementary Figure 6 from PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell–Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors
Authors: Alteber Zoya , Cojocaru Gady , Granit Roy Z. , Barbiro Inbal , Wool Assaf , Frenkel Masha , Novik Amit , Shuchami Adi , Liang Yu , Carmi Vered D. , Sabath Niv , Foreman Rob , Petrenko Natalia , He Jiang , Kliger Yossef , Levy-Barda Adva , Eitan Ram , Raban Oded , Sadot Eran , Sulimani Omri , Nathan Abraham Avi , Adewoye Henry , Ferre Pierre , Levine Zurit , Ophir Eran
Published: July 2024

Supplementary Figure 6
Supplementary Figure 3 from PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell–Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors
Authors: Alteber Zoya , Cojocaru Gady , Granit Roy Z. , Barbiro Inbal , Wool Assaf , Frenkel Masha , Novik Amit , Shuchami Adi , Liang Yu , Carmi Vered D. , Sabath Niv , Foreman Rob , Petrenko Natalia , He Jiang , Kliger Yossef , Levy-Barda Adva , Eitan Ram , Raban Oded , Sadot Eran , Sulimani Omri , Nathan Abraham Avi , Adewoye Henry , Ferre Pierre , Levine Zurit , Ophir Eran
Published: July 2024

Supplementary Figure 3
Supplementary Fig. S20 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S20. Analysis of PD-1 expression level on the surface of CD8+ T cells in TME.
Supplementary Fig. S12 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S12. Evaluation of activation of CD8+ T cells after vaccination with different GP33 formulations.
Supplementary Fig. S11 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S11. Ex vivo optical imaging of the major organs and inguinal lymph nodes.
Movie 2 from Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei
Authors: Villagomez Fabian R. , Lang Julie , Rosario Fredrick J. , Nunez-Avellaneda Daniel , Webb Patricia , Neville Margaret , Woodruff Elizabeth R. , Bitler Benjamin G.
Published: July 2024

Movie 2 - GFP
Divine law and human law in Spinoza’s Theological-Political Treatise
Authors: Oliva Luís César Guimarães
Published: July 2024

Este artigo pretende examinar os primeiros parágrafos do capítulo 4 do Tratado teológico-político de Espinosa para compreender o conceito espinosano de Lei, com especial interesse nas noções de lei divina e lei humana. A análise parte do sentido absoluto de lei, como determinação necessária, que se divide em leis dependentes da necessidade da natureza da coisa e leis dependentes da decisão humana, e mostrará como o segundo tipo de lei é ontologicamente absorvido pelo primeiro, ao mesmo tempo em que guarda sua importância do ponto de vista imaginário.
Designing Equitable Worlds: Six Orientations to Evoke the Future
Authors: Carey Hillary
Published: July 2024

This article proposes that designers can enhance and extend the efforts for social change by transforming concepts of equity and justice into material, informative, and interactive experiences. The framework introduced here outlines six orientations for evoking future outcomes in the present moment. These orientations stem from a synthesis of techniques from disciplines with varying perspectives on world-building (rhetoric, theology, political science, and art). It identifies multiple ways to evoke the future in the present. Shared and iterated through a series of workshops in racial justice contexts, the framework offers a structure for advocates to recognize how they are already building better worlds and how they can translate future visions into near-term communication pieces that engage people in their mission.
Design Thinking: Standing on the Shoulders of… Graphic Design!
Authors: Harland Robert , Meron Yaron
Published: July 2024

Prominent design discourse or advocacy in the domain of “design thinking” rarely depicts graphic design consistently or with sufficient rigor and understanding about the field's role in the development of design studies. Nor do most advocates for graphic design proffer it to be little more than a vernacular activity when competing for academic attention, despite its widespread academic presence, industry prominence, and everyday practice. The arguments presented here offer a timely critical perspective on a frequently unchallenged prevailing discourse that has echoed consistent assumptions over several decades. We call for more integrity in respect for those who design in different communication contexts, more precision in discussing how graphic design has evolved and been portrayed, and more rigor in the thoroughness and care that research into graphic design and its associated fields demands. The outcomes will be of particular interest to researchers who draw on and re-present Buchanan's four orders of design concept and offer an alternative perspective to those who suggest graphic design relies overly on intuition when deliberating on design thinking.
Designing Period Shame: Period Product Advertising in Australian Women's Magazines
Authors: Connory Jane
Published: July 2024

Graphic design, while a force for positive change, has played a role in perpetuating harmful societal norms. This article focuses on the design of period product advertising in Australian women's magazines, examining a century of advertising (1920–2020) to uncover visual patterns in messaging that have contributed to societal prejudices against menstruation. Three distinct themes were identified: describing periods as a disorder, coding the taboo, and keeping a secret. This research sheds light on the effect that graphic design and representation has on society and emphasizes the need for responsible graphic design practices in shaping a more inclusive and empathetic visual culture.
Shape of the Design Worldview: Does Language Inform the Design Sense?
Authors: Patil Koumudi
Published: July 2024

This article explores the possibility of interpreting the Banarasi design worldview of play and toys, as expressed in the Banarasi language in a community of toy designers in India. The author explored the Banarasi concept of play and toy design from the analysis of vernacular vocabulary and etymology from dictionaries, encyclopedias, and oral transcriptions of formal and informal interviews of toy designers, patrons, and shopkeepers. Besides Banarasi, Hindi (a dialect spoken in Banaras), Sanskrit (an ancient Indian language), and English (a language influencing Banarasi) vocabularies were also analyzed. The timeline of various words used to denote toys or their use revealed a pattern of change in the conception of a toy and its physical manifestation. This culture-specific meaning of toys as extended to rituals and ceremonies, their seasonality, and craftsmanship of local materials, broadens the definition of Banarasi khilona (toys) from ludic experience to a cultural representation.
Standardization of Dual-Doppler Radar–Derived Wind Fields during a Hurricane Landfall
Authors: Hirth Brian D. , Schroeder John L.
Published: July 2024

A new methodology for standardizing radar-derived elevated dual-Doppler (DD)-synthesized wind maps to the near surface is presented, leveraging the spatial variability found within the horizontal wind speed fields. The methodology is applied to a dataset collected by Texas Tech University (TTU) using two TTUKa-band mobile radar systems during the landfall of Hurricane Delta (2020) in coastal Louisiana. Relevant portions of the DD wind fields are extracted from multiple heights between 100 and 400 m above ground level, combined into 10-min segments and standardized to a reference height of 10 m and an open exposure roughness length of 0.03 m. Extractions from these standardized wind fields are compared and validated against the standardized wind measurements from a micronet of seven TTU StickNet platforms providing “ground truth” within the DD analysis domain. The validation efforts confirm the developed DD wind field standardization methodology yields robust results with correlation coefficients greater than 0.88 and mean biases less than 1%. The results of this study provide a new means for incorporating elevated DD radar data into new and existing surface wind field analysis systems geared toward generating a wind field of record during a hurricane landfall.

Significance Statement

This work presents a new methodology for using radar-generated wind fields during a hurricane landfall to support the construction of a surface wind field analysis. Because radar-based wind measurements are inherently elevated above the surface and because the wind conditions well above the ground do not directly translate to the wind conditions experienced at the ground, a method for standardizing the elevated radar wind fields to the surface provides tremendous value to generating a spatially continuous wind field of record during a hurricane landfall event to better inform event response and recovery efforts. In addition, the need for detailed wind fields of record from landfalling hurricanes that approach structural design limits is critical as a single design-level storm can alter building code return period analysis. Detailed wind fields for these high-impact events can directly inform associated updates in building codes ultimately contributing to a more resilient built environment.
Dynamics of Bubble Plumes Produced by Breaking Waves
Authors: Peláez-Zapata Daniel , Pakrashi Vikram , Dias Frédéric
Published: July 2024

Bubble plumes play a significant role in the air–sea interface by influencing processes such as air–sea gas exchange, aerosol production, modulation of oceanic carbon and nutrient cycles, and the vertical structure of the upper ocean. Using acoustic Doppler current profiler (ADCP) data collected off the west coast of Ireland, we investigate the dynamics of bubble plumes and their relationship with sea state variables. In particular, we describe the patterns of bubble plume vertical extension, duration, and periodicity. We establish a power-law relationship between the average bubble penetration depth and wind speed, consistent with previous findings. Additionally, the study reveals a significant association between whitecapping coverage and observed acoustic volume backscatter intensity, underscoring the role of wave breaking in bubble plume generation. The shape of the probability distribution of bubble plume depths reveals a transition toward stronger and more organized bubble entrainment events during higher wind speeds. Furthermore, we show that deeper bubble plumes are associated with turbulent Langmuir number Lat ∼ 0.3, highlighting the potential role of Langmuir circulation on the transport and deepening of bubble plumes. These results contribute to a better understanding of the complex interactions between ocean waves, wind, and bubble plumes, providing valuable insights for improving predictive models and enhancing our understanding of air–sea interactions.

Significance Statement

This research contributes to understanding bubble plume dynamics in the upper ocean and their relationship with sea state variables. The establishment of a power-law relationship between the bubble penetration depth and wind speed, along with the association between whitecapping coverage and acoustic backscatter intensity, contributes to improved predictive capabilities for air–sea interactions and carbon dioxide exchange. The identification of the potential influence of Langmuir circulation on bubble plume dynamics expands our understanding of the role of coherent circulations in transporting bubble plumes. Additionally, this study presents a clear methodology using commercial sensors such as an ADCP, which can be easily replicated by researchers worldwide, leading to potential advancements in our comprehension of bubble plume dynamics.
Group-k consistent measurement set maximization via maximum clique over k-uniform hypergraphs for robust multi-robot map merging
Authors: Forsgren Brendon , Kaess Michael , Vasudevan Ram , McLain Timothy W. , Mangelson Joshua G.
Published: July 2024

This paper unifies the theory of consistent-set maximization for robust outlier detection in a simultaneous localization and mapping framework. We first describe the notion of pairwise consistency before discussing how a consistency graph can be formed by evaluating pairs of measurements for consistency. Finding the largest set of consistent measurements is transformed into an instance of the maximum clique problem and can be solved relatively quickly using existing maximum-clique solvers. We then generalize our algorithm to check consistency on a group- k basis by using a generalized notion of consistency and using generalized graphs. We also present modified maximum clique algorithms that function over generalized graphs to find the set of measurements that is internally group- k consistent. We address the exponential nature of group- k consistency and present methods that can substantially decrease the number of necessary checks performed when evaluating consistency. We extend our prior work to perform data association, and to multi-agent systems in both simulation and hardware, and provide a comparison with other state-of-the-art methods.
Exploring Data Privacy and Privacy Paradox Nature of Consumers Using Block Chain Technology: Application of SLR and Bibliometric Analysis Tools
Authors: Afridi Mohd Faisal , Kumar Kompalli Sasi
Published: July 2024

This research presents an in-depth study of blockchain technology’s impact on data privacy and the consumer behaviour phenomenon known as the privacy paradox. Through a systematic literature review (SLR) and bibliometric analysis, the study delves into the effectiveness of blockchain in safeguarding personal data in an increasingly digital world. Key databases such as Scopus and Web of Science provide rich academic contributions, particularly from regions with stringent data privacy laws. The findings highlight blockchain’s effectiveness in limiting unauthorised data access, boosting user control and tackling the privacy paradox, where personal information is shared despite privacy worries. Yet, it points out challenges in aligning blockchain with legal frameworks, such as General Data Protection Regulation, particularly concerning data erasure rights. The study emphasises three themes: blockchain’s progression toward robust data protection, psychological aspects of the privacy paradox in consumer decisions and attitudes toward blockchain solutions. It notes gaps in standardisation, public awareness and blockchain’s practical applications, alongside ethical and policy issues. Conclusively, the research stresses the need for aligning technological advancements with legal and ethical frameworks, highlighting user experience in digital technology adoption. It positions blockchain as a pivotal factor in reshaping digital privacy, advocating for continued innovation and exploration in blockchain applications to ensure a secure, user-empowering future globally.
Prophylactic exchange transfusion in sickle cell disease pregnancy: a TAPS2 feasibility randomized controlled trial
Authors: Oteng-Ntim Eugene , Oakley Laura L. , Robinson Vicky , Brien Sarah , Joseph Jeannine , Sharif Joseph , McCabe Laura , Thompson Hilary , Awogbade Moji , Johns Jemma , Brunetta Denise M. , Seed Paul T.
Published: July 2024

Serial prophylactic exchange blood transfusion (SPEBT) is increasingly used in sickle cell disease (SCD) pregnancy, despite a lack of robust evidence. The Transfusion Antenatally in Pregnant Women with Sickle Cell Disease (TAPS2) study assessed the feasibility and acceptability of conducting a definitive randomized controlled trial of SPEBT (intervention) vs standard care (control) in this population. Women aged ≥18 years with SCD, between 6+0 and 18+6 weeks of singleton gestation, were randomized 1:1 every 6 -10 weeks throughout pregnancy in 7 hospitals in England. The main outcomes were recruitment rate (primary outcome), acceptability, and retention. Secondary outcomes were safety and maternal/infant outcomes. In total, 194 women were screened over 42 months (extended because of the pandemic), 88 were eligible, and 35 (39.8%) consented to participate; 18 participants were randomized to intervention, and 17 to control. Follow-up data were collected on all participants. Twelve patients in the intervention group received at least 1 SPEBT, of these, 11 received ≥3. The remaining patient was withdrawn from SPEBT because of transfusion reaction. Sixteen control participants required at least 1 transfusion. There were no statistically significant differences in maternal, infant, and postnatal outcomes. A trend toward a lower incidence of vaso-occlusive crisis, preterm delivery, and improved birthweight was observed in the intervention. The study achieved satisfactory recruitment and retention, confirming its acceptability to participants. TAPS2 demonstrates that it is feasible to perform a definitive international trial of SPEBT in SCD pregnancy. These trials were registered at www.ClinicalTrials.gov as #NCT03975894 and International Standard Randomized Controlled Trial Number (www.isrctn.com; #ISRCTN52684446).
Assessing small hydropower viability in water-scarce regions: environmental flow and climate change impacts using a SWAT+ based tool
Authors: Garcia Xavier , Estrada Laia , Llorente Oliu , Acuña Vicenç
Published: July 2024

Water-scarce regions, like the Mediterranean, face worsening conditions due to climate change, intensifying pressure on key economic sectors such as hydropower. Additionally, environmental conservation policies, particularly the implementation of environmental flows, present challenges for hydropower systems. Certainty regarding the impact of these factors on future hydropower production is crucial for informed decision-making in the transition to sustainable energy. This study introduces S + HydPower, a tool coupled with SWAT+ to assess climate change and watershed management effects on small hydropower plant (SHP) systems. In this study, we used this tool to investigate the consequences of implementing environmental flows and climate change on run-of-river SHPs in the Catalan River Basin District (CRBD), in Catalonia. The results show that applying environmental flows would lead to a significant 27% reduction in SHP production. However, this reduction would represent only 0.25% of the region’s current energy demand. Furthermore, the study reveals a potential 38% to 73% reduction in SHP production by the end of the twenty-first century due to the combined effects of environmental flows and climate change. This suggests a substantial decline in run-of-river SHP’s contribution to the CRBD’s electricity supply. These findings emphasize the need to explore alternative and sustainable energy sources to ensure the long-term reliability and resilience of the region’s energy supply.
The efficacy of lumbar erector spinae plane block for postoperative analgesia management in patients undergoing lumbar unilateral bi-portal endoscopic surgery: a prospective randomized controlled trial
Authors: Zhao Dan , Wang Hongkun , Liu Xin , Gao Zhenfeng , Sun Chao , Zhang Quanyi
Published: July 2024

Background

The efficacy and reliability of erector spinae plane block (ESPB) in posterior open lumbar spine surgery has been demonstrated; however, few randomized controlled trials of lumbar ESPB (L-ESPB) in lumbar unilateral bi-portal endoscopic (UBE) surgery have been reported.

Methods

A total of 120 patients, aged 18 to 65 (who underwent elective lumbar UBE surgery under general anesthesia and exhibited an American Society of Anesthesiologists physical status of I to III) were randomly assigned in a 1:1 ratio to the ESPB group and the Control group. Ultrasound(US)-guided unilateral single-shot 0.25% ropivacaine L-ESPB was performed in the ESPB group, but not in the control group. Postoperative analgesic strategy for all patients: patient controlled intravenous analgesia (PCIA, diluted and dosed with fentanyl alone) was initiated immediately after surgery combined with oral compound codeine phosphate and ibuprofen sustained release tablets (1 tablet containing ibuprofen 200 mg and codeine 13 mg, 1 tablet/q12h) commenced 6 h postoperatively. We collected and compared patient-centred correlates intraoperatively and 48 h postoperatively. The primary outcomes were intraoperative and postoperative opioid consumption and postoperative quality of recovery-15 (QoR-15) scores.

Results

Compared to the control group (n = 56), the ESPB group (n = 58) significantly reduced intraoperative remifentanil consumption (estimated median difference − 280 mcg, 95% confidence interval [CI] − 360 to − 200,p < 0.001, power = 100%); significantly reduced fentanyl consumption at 24 h postoperatively (estimated median difference − 80mcg, 95%[CI] − 128 to − 32,p = 0.001, power = 90%); and significantly enhanced the QoR-15 score at 24 h postoperatively (estimated median difference 11, 95%[CI] 8 to 14,p < 0.001, power = 100%). Compared to the control group, the ESPB group enhanced the resting numeric rating scale (NRS) score up to 8 h postoperatively, and the active movement NRS score up to 4 h postoperatively. The incidence of postoperative nausea and vomiting (PONV) (p = 0.015, power = 70%), abdominal distension (p = 0.024, power = 64%), and muscular calf vein thrombosis (MCVT) (p = 0.033, power = 58%) was lower in the ESPB group than in the control group. Moreover, the occurrence of L-ESPB related adverse reactions was not found herein.

Conclusion

US-guided L-ESPB reduces intraoperative and 24 h postoperative opioid consumption and improves patients' QoR-15 scores at 24 h postoperatively. L-ESPB can be safely and effectively utilized in lumbar UBE surgery.

Trial registration

Chinese Clinical Trial Registry,ChiCTR2200061908, date of registration: 10/07/2022. Registry URL.
Comparison of the efficacy and safety of ciprofol and propofol in sedating patients in the operating room and outside the operating room: a meta-analysis and systematic review
Authors: Yang Yanni , Lang Zekun , Wang Xiumei , Yang Peining , Meng Ning , Xing Yang , Liu Yatao
Published: July 2024

Background

As a new type of intravenous anesthetic, ciprofol has the advantages of fast onset of action, fast recovery and high clearance rate. This study aimed to investigate the effectiveness and safety of ciprofol versus traditional propofol for anesthesia and sedation in and out of the operating room.

Methods

We searched the literature in PubMed, Web of Science, Cochrane Library, and Embase databases from January 2021 to December 2023. All clinical studies comparing the sedative effects of propofol and ciprofol, both inside and outside the operating room, were included in our trial. The main outcome measures were induction time and incidence of injection-site pain. Data are merged using risk ratio and standardized mean difference with 95% confidence interval. Subgroup analysis, meta-regression, sensitivity analysis, and publication bias were performed. The study protocol was prospectively registered with PROSPERO (CRD42023447747).

Results

A total of 15 randomized, controlled trials involving 2002 patients were included in this study. Compared with propofol, ciprofol has a longer induction time in the operating room but a shorter induction time in non-operating room settings. Ciprofol can effectively reduce the risk of injection-site pain and respiratory depression both inside and outside the operating room. In addition, the risk of drug-related hypotension induced with ciprofol in the operating room is lower, but the awakening time is also longer. Meta-regression analysis showed that neither age nor BMI were potential sources of heterogeneity. Funnel plot, egger and begg tests showed no significant publication bias. Sensitivity analyzes indicate that our results are robust and reliable.

Conclusion

Ciprofol has absolute advantages in reducing the risk of injection-site pain and respiratory depression, both in and outside operating room. Intraoperative use of ciprofol reduces the risk of drug-related hypotension and may also reduce the risk of intraoperative physical movements. However, ciprofol may have longer induction and awakening time than propofol.
How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation
Authors: De Dios Pérez Blanca , Merchán-Baeza Jose Antonio , Powers Katie , Craven Kristelle , Holmes Jain , Phillips Julie , Tyerman Ruth , Radford Kate
Published: July 2024

Background

Integrating complex interventions within healthcare settings can be challenging. Mentoring can be embedded within a randomised controlled trial (RCT) to upskill and support those delivering the intervention. This study aimed to understand, from a realist perspective, how mentoring worked to support implementation fidelity for occupational therapists (OTs) delivering a vocational rehabilitation (VR) intervention within the context of an RCT.

Methods

A realist evaluation using secondary data (emails, mentoring record forms, interviews) collected as part of an RCT. Three researchers coded the data following content analysis, focused on refining or refuting an initial programme theory by exploring the interactions between context, mechanisms, and outcomes. The research team met to further refine the programme theories.

Results

Data from 584 emails, 184 mentoring record forms, and 25 interviews were analysed following a realist approach. We developed a programme theory consisting of two contexts (trial set-up, ongoing mentoring), nine mechanisms (collective understanding, monitoring, timely support, positive reinforcement, reflective practice, support data completeness, facilitation strategy, shared learning experience, management of research and clinical duties), and three outcomes (improved confidence, improved fidelity, reduced contamination).

Conclusions

Offering mentoring support to OTs delivering a VR intervention as part of an RCT improves intervention fidelity and reduces the risk of contamination. It improves OTs’ understanding of the differences between their clinical and research roles and increases their confidence and competence in trial paperwork completion and identification of potential contamination issues.