Angiographic Findings and Post–Percutaneous Coronary Intervention Fractional Flow Reserve
Authors: Zhang Jinlong , Hwang Doyeon , Yang Seokhun , Hu Xinyang , Lee Joo Myung , Nam Chang-Wook , Shin Eun-Seok , Doh Joon-Hyung , Hoshino Masahiro , Hamaya Rikuta , Kanaji Yoshihisa , Murai Tadashi , Zhang Jun-Jie , Ye Fei , Li Xiaobo , Ge Zhen , Chen Shao-Liang , Kakuta Tsunekazu , Wang Jian’an , Koo Bon-Kwon 
Published: June 2024

Importance

The associations between angiographic findings and post–percutaneous coronary intervention (PCI) fractional flow reserve (FFR) and their clinical relevance according to residual functional disease burden have not been thoroughly investigated.

Objectives

To evaluate the association of angiographic and physiologic parameters according to residual functional disease burden after drug-eluting stent implantation.

Design, Setting, and Participants

This cohort study population was from the International Post-PCI FFR registry, which incorporated 4 registries from Korea, China, and Japan. Patients who underwent angiographically successful second-generation drug-eluting stent implantation and post-PCI FFR measurement were included in the analysis. The patients were divided into 3 groups according to the residual disease burden (post-PCI FFR ≤0.80 [residual ischemia], 0.81-0.86 [suboptimal], and &amp;gt;0.86 [optimal]). The data were collected from August 23, 2018, to June 11, 2019, and the current analysis was performed from January 11, 2022, to October 7, 2023.

Exposures

Angiographic parameters and post-PCI FFR.

Main Outcomes and Measures

The primary outcome was target vessel failure (TVF), defined as a composite of cardiac death, target vessel–related myocardial infarction, and target vessel revascularization (TVR) at 2 years.

Results

In this cohort of 2147 patients, the mean (SD) age was 64.3 (10.0) years, and 1644 patients (76.6%) were men. Based on the post-PCI physiologic status, 269 patients (12.5%) had residual ischemia, 551 (25.7%) had suboptimal results, and 1327 (61.8%) had optimal results. Angiographic parameters had poor correlations with post-PCI FFR (r &amp;lt; 0.20). Post-PCI FFR was isolated from all angiographic parameters in the unsupervised hierarchical cluster analysis. Post-PCI FFR was associated with the occurrence of TVF (adjusted hazard ratio [AHR] per post-PCI FFR 0.01 increase, 0.94 [95% CI, 0.92-0.97]; P &amp;lt; .001), but angiographic parameters were not. The residual ischemia group had a significantly higher rate of TVF than the suboptimal group (AHR, 1.75 [95% CI, 1.08-2.83]; P = .02) and the optimal group (AHR, 2.94 [95% CI, 1.82-4.73]; P &amp;lt; .001). The TVR in the residual ischemia group was predominantly associated with TVR in the nonstented segment (14 [53.8%]), unlike the other 2 groups (3 [10.0%] in the suboptimal group and 13 [30.2%] in the optimal group).

Conclusions and Relevance

In this cohort study of the International Post-PCI FFR registry, a low degree of associations were observed between angiographic and physiologic parameters after PCI. Post-PCI FFR, unlike angiographic parameters, was associated with clinical events and the distribution of clinical events. The current study supports the use of post-PCI FFR as a procedural quality metric and further prospective study is warranted.