bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ANTHELMINTIC POTENTIAL OF TURMERIC (Curcuma domestica) EXTRACT AGAINST Ascaridia galli WORMS IN CHICKENS In Vivo
Authors: Kusuma Yudiani Rina , Dai Zahid Fahmi , Sunardi Sunardi , Mubarokah Wida Wahidah
Published: November 2022

Ascaridia galli worm was chicken parasite that inflicted significant economic loss for breeders. Expensive commercial anthelmintic drug and drug resistance were the reasons why herbal anthelmintic study became strategic. The study aimed at finding out the effect of the application of turmeric (Curcuma domestica) extract in vivo on the number of eggs per gram (EPG) in feces. It used 30 free ranging chickens that were classified into 2 groups of 5 chickens with 3 repetitions. Group I served as control (Aquadestilata) and group II was treated using turmeric extract at the concentration of 2%, 3 times a week. Observation was conducted on days 1, 7, 14, 21, and 28. The results were then analyzed using Anova and advanced LSD test. The results of in vivo test showed that the application of the turmeric significantly decreased the number of the EPG as compared to negative control. The application of the turmeric had anthelmintic potential and significant effect on the decrease in the number of the EPG.
STUDI HISTOPATOLOGIS TUMOR PADA HEWAN KESAYANGAN AND WILD ANIMAL
Authors: Widyarini Sitarina , Sultan Sugiyono , Kristiangingrum Yuli Purwandari , Sutrisno Bambang
Published: November 2022

Penelitian ini dilakukan untuk mengamati gambaran histomorfologis (berdasarkan pada histogenesis dan sifat pertumbuhan tumor), pada berbagai sampel tumor dari hewan kesayangan (anjing dan kucing) dan wild animals (beruang) koleksi Departemen Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada. Duapuluh satu sampel (22) dari organ yang diduga jaringan tumor yang diperoleh dari Dokter Hewan Praktisi maupun Rumah Sakit Hewan selama tahun 2019 digunakan dalam penelitian ini. Semua sampel tersimpan dalam kontener berisi larutan formalin 10%. Selanjutnya sampel diproses dan diwarnai dengan Hematoxylin-Eosin. Pengamatan terhadap histogenesis dan sifat pertumbuhan tumor dilakulan dengan menggunakan mikroskop cahaya dengam pembesaran 200X dan 400X dan selanjutnya dilakukan dokumentasi dengan pengambilan foto. Analisis dilakukan secara deskriptif dengan membandingan dengan referensi histomofologis tumor pada hewan. Hasil penelitian memperlihatkan bahwa selama tahun 2019, jumlah sampel tumor kulit dilaporkan paling banyak  63.63% (14/22), diikuti dengan jumlah sampel tumor pada kelenjar mammae 22,72% (5/22), liver-duktus biliverus 18.18% (4/22), tulang 4,54% (1/22) dan metastasis paru-paru dan metastasis paru-paru dari jaringan tulang sejumlah 4,54% (1/22). Hewan asal tumor paling banyak ditemukan pada kucing dan anjing masing-masing 59% dan 34%. Hasil pengamatan terhadap gambaran histomorfologis ditemukan adenokarsinoma mammae (tubulopapillary carsinoma, solid adenocarsinoma, lipid-rich adenokarsinoma),  fibroadenomatous hiperplasia mammae, karsinoma sel skuamosa, papiloma, adenoma kelenjar hepatoid, melanositosis, fibrosarkoma, kolangiokarsinoma dan osteosarkoma.
Essentializing the Feminist Implausibility for Bathsheba to Subvert Patriarchal Dominance in Far from the Madding Crowd
Authors: Guijun Li , Jun Luo
Published: November 2022

Adequate critical attention has been paid to Thomas hardy who has developed a strong aesthetic and artistic interest in the feminist awareness of Bathsheba epitomized in his novel Far from the Madding Crowd (1874) while inadequate critical concern shown for the implausibility for her to subvert the patriarchal dominance she has to be faced with. Thus, this paper will give an overall interpretation of a series of events happened to her to show that in spite of the appropriate and adequate development and improvement of her female awareness that is inclined to enable her to have a good understanding of the historical, cultural, and, social implications of feminism and to make best use of those rich implications to challenge the historical, cultural, and, social dominance of patriarchal history, patriarchal culture, and, patriarchal society in an ambitious fashion and in an aggressive fashion, she has eventually turned out to be unable to subvert the historical, cultural, and, social governance of men in the patriarchal history, patriarchal culture, and, patriarchal society where she lives in a thorough fashion and she has to return to the acceptance of or even submission to the patriarchal history, patriarchal culture, and, patriarchal society she has refused in her previous life and experience, for it is difficult or impossible for her to achieve a great success in subverting the patriarchal mechanism most women have been prisoned in an individual fashion on account of the asymmetrical perceptive and cognitive balance between men and women at that historical moment when the historical, cultural, and, social dominance of men has been popularized in a substantial fashion and in a sufficient fashion in the lives and experiences of men and women as what has been impressed in the aesthetic and artistic production of this novel in a particular fashion.
IN VITRO ANTIPLATELET ACTIVITY OF AN ISOFLAVANONE ISOLATED FROM METHANOLIC EXTRACT OF EMBLICA OFFICINALIS FRUITS
Authors: L. ANILA , HASHIM M. S.
Published: November 2022

Objective: In this study, we aimed to isolate a polyphenolic compound from a polyphenolic-rich fraction from Emblica officinalis fruits and also study its effect on adenosine diphosphate (ADP) and collagen-induced in vitro platelet aggregation.
Methods: The polyphenolic-rich fraction was prepared by 80% methanolic extraction. The residue was extracted successively with hexane, benzene, ethyl acetate and n-butanol. Ethyl acetate residue was selected for column chromatography because of its high polyphenolic content. It was subjected to repeated column chromatography of series with different eluents of increasing polarity. A brown amorphous powder was obtained from ethyl acetate: methanol (7:3) fraction. This sample was subjected to UV-visible spectrum, IR spectrum, 1H NMR, 13C NMR and electrospray mass spectrum (ES-MS) studies for its structural elucidation.
Results: A compound, 5, 7, 4'-trihydroxy 3'-methoxy isoflavanone was identified from polyphenolic rich ethyl acetate: methanol (7:3) fraction separated from the 80% methanolic extract of Embica officinalis fruits by repeated column chromatography. Yield of the compound was 421.05 mg/kg. This compound exhibited antiplatelet activity well comparable with that of quercetin.
Conclusion: The present study proved that the isolated compound 5, 7, 4'-trihydroxy 3'-methoxy isoflavanone exerts a significant inhibitory activity on ADP and collagen-induced in vitro platelet aggregation, which can be considered as an effective remedy for alleviating complications of cardiovascular diseases.
Effect of discs harrow use on lixisol roughness and clods sizes in Burkina Faso
Authors: Albert Barro , Florentin Sanon , Siébou Palé , Kalifa Coulibaly , Mamadou Dayo , Maurice Kientega , Bismarck Nacro Hassan
Published: November 2022

Soil tillage allows a good establishment of crops in Burkina Faso. The aim of the study conducted in Saria is evaluation of the disc harrow used for tillage in order to find ways of mitigating these negative effects. The discs harrow evaluation is done at three speeds on a lixisol in Saria. The operation is carried out at two moisture levels, 9 and 12%. Measurements are made on labor time, tillage depth and width, surface roughness and clod sizes. The results indicate that labor time per hectare decreases with speed. Between 2.2 and 10.4 km.h-1, the time goes from 4.00 h.ha-1 to 1.25 h.ha-1. Under these conditions, the soil surface roughness index varies from 1.27 at low speed to 1.06 for high speed. The size of clods increases from 1550 cm3 2.2 km.h-1 to 81 cm3 for 10.4 km.h-1. The reduction of the clods sizes makes the plots sensitive to runoff and soil erosion. Soil tillage at an average speed of 6 to 7 km.h-1 maintain the roughness and the clods sizes and makes it possible to achieve a time of 1.6 h.ha-1. The traction force is 315 DaN for 7 cm deep and 210 cm wide. It is possible to reduce labor time by increasing the tillage width and maintaining a speed of 6 km.h-1.
Uso de las habilidades digitales en el proceso de enseñanza-aprendizaje en ciencias de la información en un entorno virtual durante la pandemia por Covid 19
Authors: Oliva-Cruz Eduardo , Mata-Puente Adriana
Published: November 2022

El objetivo de este trabajo es analizar las habilidades que han desarrollado los docentes y estudiantes de la Facultad de Ciencias de la Información de la Universidad Autónoma de San Luis Potosí (UASLP) a partir del confinamiento por la contingencia sanitaria por Covid 19. Se analizan 130 estudiantes de esa facultad, 10 docentes y 17 materias impartidas durante el periodo de marzo de 2020 a junio de 2021. Se aplicaron encuestas que indagan sobre las habilidades tecnológicas y didácticas puestas en práctica durante 12 meses. En el caso de los estudiantes, además se indagó sobre su situación económica y su acceso a internet. Se concluye que tanto docentes como estudiantes se han adaptado al proceso de enseñanza-aprendizaje en línea; las competencias digitales son adecuadas, pero no suficientes para alcanzar los objetivos del aprendizaje.
Robot Ankle Foot Orthosis with Auto Flexion Mode for Foot Drop Training on Post-Stroke Patient in Indonesia
Authors: Adiputra,Ph.D Dimas , Ubaidillah Ubaidillah , Asfari Ully , SulistiyoBudiWaspada Hari , Humaidi Reza , WahyuPrakoso Bagas , NurHalisyah Andi
Published: November 2022

Robot Ankle Foot Orthosis (AFO) has been proven to assist the gait impairment, such as the foot drop. However, development challenge is still remains, such as the trade-off between complexity, functionality and cost. High functionality resulted in high cost, bulky, and complex device. But affordability and simplicity may decrease functionality. Therefore, this research proposed a robot AFO, which has the necessary function of auto dorsi-plantarflexion so it can keep the affordability and simplicity. The robot AFO consists of structure, electronics part and algorithm. The structure is custom made according to the user’s anatomy. A brushless DC (BLDC) motor, Force-Sensing Resistor (FSR) and microcontroller builds the electronic parts. The BLDC motor actuates the flexion, while the FSR detects the gait phase to determine the action. Both are integrated by the microcontroller with the P control algorithm that commands the BLDC motor to generate necessary torque so it rotates in a constant speed. A functionality test has been carried out on the robot AFO, where the robot AFO perform a dorsi-plantarflexion continuously in three conditions, such as no load, 1 Kg load, and foot load. The robot AFO successfully performed a constant velocity rotation in both directions, in all conditions. In the case of 1 Kg load, the maximum angular speed is 0.7 rad/s dorsiflexion and -1.8 rad/s plantarflexion. The torque keeps increasing and decreasing from -0.3 Nm to 4 Nm to keep the angular velocity. The result shows that the robot AFO can perform the necessary function to assist the foot drop training. Functionality test on the gait detection has also been done where it shows that the robot AFO can detect the four gait phases accurately. The robot AFO has been tested and future study should test the robot on a real post-stroke patient to see the effect of the gait control in reality.
Некоторые аспекты развития концепции «нового города» в теории отечественного градостроительства
Authors: Жеблиенок Наталья , Малинина Светлана
Published: November 2022

Статья иллюстрирует промежуточные резуль­таты исследования эволюции концепции «нового поселения» в теории отечественного градостроительства. Был системати­зирован ряд публикаций ХХ века с частичным обзором более свежих материалов последних десятилетий.

На до-теоретическом этапе развития отечественного градостроительства можно говорить о приоритете концепции «новый - как создаваемый на новом прежде пустующем месте». В начале ХХ века она сменилась поисками «нового» в значении «идеального, устроенного наилучшим образом». Последующие десятилетия (1915-1940) внесли практику рас­смотрения города как социального, экономического, обще­ственного явления. Город покинул категорию «места» и стал «инструментом». «Новым» стал называться город или посёлок, который располагал к новым типам социальных отношений. Стала складываться многоуровневая концепция «новизны». В дальнейшем развитие получили дополнительные трактов­ки: так, для периода 1950-1985 годов характерен подход к новому поселению как «комплексно решённому». Интерес к развитию агломераций и усиление эконом-географического представительства в отрасли способствовали установлению подхода, который рассматривает запланированные новые поселения как недостающие компоненты пространственной системы расселения страны. Наконец, современный этап, начавшийся примерно в 1980-е годы (и продолжающаяся вплоть до настоящего времени) может быть охарактеризован через представление о новом как «обладающем новыми потребительскими качествами, новыми формами ценности и создающим новый потребительский опыт».
Основные тенденции развития гражданского строительства на современном этапе
Authors: Гурьев Владимир , Яхкинд Светлана
Published: November 2022

Развитие малоэтажной застройки становится современным трендом в гражданском строительстве. Анализ проектной практики реализации застройки в регионах пока­зывает, что наряду с высотным строительством развивается и малоэтажное, объем ввода которого в 2021 году составил 52% от общего объёма жилищного строительства.

В статье проводится сравнение факторов, которые при строительстве высотных объектов и малоэтажной застройки определяют увеличение стоимости и затрат при эксплуатации высотных объектов, а также способствуют снижению стои­мости строительства малоэтажной застройки, в том числе за счёт применения типовых проектов жилых и общественных зданий.

Применение типовых проектов объектов социальной инфраструктуры (школы, ДОО, амбулатории, ФОК и др.) в малоэтажной застройке позволит инвесторам уменьшить объём вложений на проектирование, в том числе при «при­вязке» этих проектов, разработанных с учётом формируе­мой индустриальной базы предприятий промышленности.

Совместно с регионами и федеральными органами ис­полнительной власти необходимо определить номенклатуру рекомендуемых типовых проектов объектов социальной и других видов инфраструктуры, разработку которых целесоо­бразно возложить на специализированный научно-проектный институт, подведомственный Минстрою России.
Misconceptions, Hesitancy and Efficacy of COVID-19 Vaccination in Dental Surgeons Working in A Teaching Dental Hospital, Peshawar
Authors: Zaib Aalia , Gilani Syed Imran , Muhammad Asif , Zaib Ubaid
Published: November 2022

The objective of this study was to assess misconceptions, hesitancy and efficacy of COVID-19 Vaccine among Faculty, House Officers (HO) and Postgraduates (PG) dental trainees towards the novel COVID-19 vaccine and to assess the association between COVID-19 vaccine acceptance and conspiracy beliefs. A cross sectional study was conducted on 150 participants from Sardar Begum Dental hospital, Peshawar, Khyber Pakhtunkhwa. A self-administered questionnaire was developed with questions related to perception of participants regarding misconceptions, safety, hesitancy and efficacy of COVID-19 Vaccination. The questionnaire comprised of 26 closed-ended questions. Data was analyzed using SPSS statistical package 26.0. More than half of the participants (87.3%) reported to be tested positive for COVID-19 at some point. Majority of participants (87.3%) reported that they were vaccinated and 86.7% reported that they had post-vaccination reactions such as pain in arm, fever and body aches. A notable number of participants that were part of the study believed in the misconceptions related to the COVID-19 vaccine. This study concluded that despite widespread vaccination awareness campaigns, significant number of dental surgeons believed in misconceptions regarding COVID-19 vaccination that may pose a significant challenge to Pakistan's COVID-19 immunization program.
1,3,4-THIADIAZOLE AND ITS DERIVATIVES: AN OVERVIEW ON CRYSTAL STRUCTURE AND TRIBOLOGY ACTIVITIES
Authors: Abdul Basir Nurul Fatimah , Abdul Wahab Yasmin , Johan Mohd Rafie , Khaligh Nader Ghaffari
Published: November 2022

1,3,4-thiadiazole derivatives has been attracted great attention due to application in various areas. Synthesis and crystal structure is briefly investigated. Their application in high temperature and high pressure as anti-friction and antiwear, and improve the anti-wear and extreme pressure properties have been described. The effect of various 1,3,4-thiadiazole additives on the tribological properties of base oils is studied. This paper aims to present an overview of the role of 1,3,4-thiadiazole and its derivative in improving the tribological properties of base oils.
The Impact of Virtual Interviews on the Resident Candidate: A Before-and-After Comparison
Authors: Bishop Thomas , Heinrich Laura , Greenberg Jenna B. , Wenner Rudy , Furst Wendy , Wong Jean
Published: November 2022

Background and Objectives: A significant impact of the COVID-19 pandemic on family medicine residency recruitment has been a requested transition to virtual interviewing by the Association of American Medical Colleges and the academic family medicine community. This has led to creative and adaptive approaches to virtual interviewing with little previous knowledge, experience, or processes. This work describes the impact of transitioning to virtual recruitment on applicants’ reported experiences and factors influencing decision-making with family medicine at a large research university.
Methods: We made a comparison of 2 years of in-person interview day surveys with 2 years of virtual interview surveys following transition to virtual recruitment. We tested differences between in-person and virtual interviews for significance using χ2 tests.
Results: There were significant differences in factors influencing a candidate’s decision to apply. Candidates who participated in virtual interviews were more interested in urban training settings, a community setting, and obstetrical training compared with the in-person interview cohort. Nearly 50% of virtual candidates reported preferring virtual interviews in the future. There were no significant differences in how candidates rated their experience of the interview process and they indicated adequate contact with resident personnel despite a transition to virtual interviews.
Conclusions: The transition to virtual recruitment has been well received by candidates, as indicated by the high positive ratings of the cohorts. The transition has not resulted in a negative impact on the recruitment experience or the ability to meet with resident leadership.
Educación situada y valores en disputa
Authors: Ruiz Morales Maicol Mauricio
Published: November 2022

El libro Educación situada y valores en disputa se plantea como un diálogo, entre el saber sabio y el alma docente, para dar cuenta de la enorme necesidad que se tiene, en el mundo contemporáneo, de asumir la educación como una oportunidad para que las personas y sus contextos se sitúen en el centro de las discusiones relevantes. En este sentido, también se presenta como una invitación a sentipensar la educación como producción cultural situada que produce personas educadas de múltiples maneras en el entrecruce de experiencias, saberes y sabedores instituidos e instituyentes; todo ello en el marco de procesos y estructuras sociales tensionadas entre la dominación y la resistencia, el orden y el caos, la intencionalidad lúdica y la emergencia paidíica; además, una producción inmersa en las disputas en torno al valor, al valor de la vida, al valor de las cosas, al valor de las personas y de las relaciones, así como al valor de lo que hacemos, de lo que sentimos, de lo que pensamos, de lo que producimos y de lo que aprendemos.
El fracaso de la no exigencia educativa. Crítica del paradigma pedagógico marxista-posestructuralista y defensa del sistema meritocrático de incentivos en Santa Fe, Argentina
Authors: Micheletti Rafael Eduardo
Published: November 2022

El objetivo de este artículo es problematizar y analizar los efectos del paradigma educativo marxista-posestructuralista en Santa Fe, Argentina. Se utiliza una metodología mixta, que consiste en un análisis de caso, apoyado en datos estadísticos y en una encuesta realizada a ciento trece docentes de la mencionada provincia. La hipótesis es que la hegemonía de dicho paradigma ha dado lugar a una destrucción de los sistemas de incentivos desde un posicionamiento antimeritocrático. En consecuencia, el nivel académico alcanzado por los alumnos ha estado decayendo sostenidamente. Se arguye que la destrucción de los incentivos afecta, en mayor medida, a los alumnos vulnerables o excluidos, puesto que son ellos quienes están más afectados. Así, el dogma antimeritocrático amplía la brecha educativa, disminuye el desarrollo cognitivo general de la población y genera una enorme pérdida de tiempo valioso para perfeccionar los sistemas de incentivos.
HHV8 and EBV negative primary effusion-based lymphoma: a case report of a new provisional entity and review of literature.
Authors: Canelo-Vilaseca Marta , Melendo Gustavo Tapia , Orna Elisa , Sorigué Marc , Granada Isabel , Palomar-Muñoz Azahara , Castillo Ana , Grau Javier , Mesa Alba , Ribera Josep-Maria , Sancho Juan Manuel , Navarro Jose-Tomas
Published: November 2022

Primary effusion lymphoma (PEL) is a rare non-Hodgkin lymphoma confined
exclusively to body cavities without detectable tumor masses. The term
PEL-like is an entity similar to PEL in clinical presentation but
without relation to human herpesvirus 8 (HHV8). We report a case of
HHV8- and EBV-negative primary effusion-based lymphoma.
Berberine inhibits intracellular Ca2+ signals in mouse pancreatic acinar cells through M3 muscarinic receptors: New target, mechanism, and implication
Authors: Xia Kunkun , Hei Zhijun , Li Shuangtao , Song Huimin , Huang Rongni , Ji Xiaoyu , Zhang Fenni , Shen Jian-Xin , Zhang Shuijun , Peng Shuang , WU JIE
Published: November 2022

Background and Purpose: Berberine, a natural isoquinoline alkaloid,
exhibits a variety of pharmacological effects but the pharmacological
targets and mechanisms are remained elusive. Here, we report a novel
finding that berberine inhibits acetylcholine (ACh)-induced Ca2+
oscillations which may underlie the pathogenesis of the
L-arginine-induced mouse model of acute pancreatitis (AP). Experimental
approach: Patch-clamp recordings and confocal Ca2+ imaging were applied
in acute dissociated pancreatic acinar cells prepared from CD1 mice to
examine the effects of berberine on ACh-induced Ca2+ oscillations. The
L-arginine-induced acute pancreatitis mouse model was used to evaluate
the protective effects of berberine against pathological changes. Key
Results: Whole-cell patch-clamp recordings showed that berberine (from
0.1 to 10 µM) reduced ACh-induced Ca2+ oscillations in a
concentration-dependent manner, and this inhibition was also depended on
ACh concentrations. The inhibitory effect of berberine neither occurred
in intracellular targets nor extracellular cholecystokinin (CCK)
receptors, chloride (Cl-) channels, and store-operated Ca2+ channels.
Together, the results demonstrate that berberine directly inhibits M3
muscarinic receptors, which is further confirmed by the evidence of the
interaction between berberine and M3 receptors in acinar cells. In a
L-arginine AP model, berberine eliminates the ACh-induced Ca2+
oscillations, the elevation of pancreatic amylase and pulmonary
myeloperoxidase, and improves acinar cell pathological injury.
Conclusions and Implications: We provide novel evidence that berberine
inhibits M3 receptors, in turn eliminates ACh-induced Ca2+ oscillations
and L-arginine-enhanced Ca2+ signaling, which underlie the protective
effects of berberine on pancreatic acinar cells against pathological
changes in an acute pancreatitis model.
Can body position be arrhythmogenic?
Authors: Broek Johannes L.P.M. van den , Heydari Samaneh , Zhan Zhuozhao , Veer Marcel van ’t , Sammali Federica , Overeem Sebastiaan , Heuvel Edwin R. van den , Dekker Lukas
Published: November 2022

Introduction Palpitations occurring in specific body positions
are often reported by patients, but the effect of body position on
arrhythmia has received little research attention. We hypothesize that
resting body position can exert pro-arrhythmogenic effects in various
ways. For example, lateral body position is known to increase change
atrial and pulmonary vein dimensions. Methods This
observational study capitalizes on overnight polysomnography (PSG)
recordings from a tertiary sleep clinic. PSGs were retrieved based on
any mention of cardiac arrhythmia in the clinical report, irrespective
of primary sleep diagnosis and (cardiac) comorbidities. Every instance
of atrial ectopy was annotated and subgroups with a homogenous rate of
atrial ectopy were created based on the Dunn index. A generalized linear
mixed-effects model using age, sex, gender, sleep stage and body
position was used to analyse the total amount of atrial ectopy in each
combination of sleep stage and body position. Backward elimination was
then performed to select the best subset of variables for the model.
Results PSGs of 22 patients (14% female, mean age 61y) were
clustered and analysed. Body position, sleep stage, age or sex did not
have a significant effect on atrial ectopy in the subgroup with a low
rate of atrial ectopy (N=18). However, body position did significantly
affect the rate of atrial ectopy in the subgroup with a high rate of
atrial ectopy (N=4; 18%). Discussion In each individual with a
high rate of atrial ectopy, the rate of atrial ectopy was significantly
higher in either left or right decubital or supine position. Increase in
atrial wall stretch in lateral decubital position and obstructive
respiratory events in positional sleep apnea are two possible
pathophysiological mechanisms, while avoidance of a body position due to
symptomatic atrial ectopy in that position is an important limitation.
Conclusion In a selected cohort of patients with a high rate of
atrial ectopy during overnight polysomnography, the occurrence of atrial
ectopy is related to resting body position.
R-SoftPosit: R-based Software Implementation for Unum Posits
Authors: Ismail Muhammad , Ali Amjad , Waqas Maria , Malik Mahnoor
Published: November 2022

Presently, the IEEE 754 Float is the most commonly used standard to
represent floating point values, which is capable of representing fairly
extensive range of numbers. Recently, a new number format has been
coined among the research community, termed Unum. The Unum format is in
the evolutionary phase and is being standardized for efficient and
accurate representations keeping the number of required bits quite
limited at the same time. Many researchers consider the Posits feature
of Unum as a viable alternate to the IEEE Floats as it provides number
representations in a broader range and higher accuracy as compared to
IEEE Floats for a given number of bits. This paper presents R-SoftPosit,
an R-based software implementation of Posits to facilitate comparison
between Posits and Floats. The article describes the steps followed for
the development of the package, lists of classes and functions created,
concerning documentation, and reproducible examples. This R-based
package aims to provide a convenient tool to explore and test various
features of Posits.
On a boundary value problem for a class of equations of mixed type
Authors: Menglibay Ruziev , Nargiza Yuldasheva
Published: November 2022

In this paper we study a nonlocal boundary value problem for Gellerstedt
equation with singular coefficient in an unbounded domain. With the help
of the method of integral equations and the principle of extremum we
prove the unique solvability of the considered problem.
Single cell expression profile of connexins in the mouse substantia nigra pars compacta
Authors: Hernandez-Sanchez Araceli , Soto-Orduño Elier , Mendez J Alfredo
Published: November 2022

Although the expression of several connexins has been reported in the
central nervous system, only Cx36 and Cx45 have been undoubtedly
demonstrated as part of electrical synapses. Dopamine neurons of the
substantia nigra pars compacta (SNc), whose electrical activity is
important for goal directed behavior, learning, working memory, reward
and modulation of motor activity, communicate with other Dopamine
neurons through electrical synapses. However, the expression profile of
connexins in the SNc has only been determined in the rat. Considering
that electrical synchronization of Dopamine neurons could have important
roles in the modulation of levels of Dopamine released both locally and
in the areas of innervation, and therefore in the functioning of
Dopamine circuits, we decided to determine the expression profile of
connexins in freshly isolated cells from SNc of adult mice. Using single
cell RT-PCR, we show that a subset of DA neurons, and neurons of
glutamate and GABA phenotypes, express Cx45 as well Cx26, Cx30, Cx31.1,
Cx32 and Cx43, but not Cx36. Thus our results suggest that in adult
mice, Cx45 is the connexin used by some of DA neurons of the SNc to be
electrically coupled. Our results also suggest that glutamate and GABA
neurons of the SNc, could also be electrically coupled with DA neurons.
Despite the inability of the other connexins to form functional gap
junctions in neurons, the expression of Cx26, Cx30, Cx32 and Cx43 may be
the reflect of the ability of the neurons of SNc to release
neuromodulators through hemichannel activity.
NAPPN Annual Conference Abstract: Volume Estimation of Sweetpotatoes using LiDAR
Authors: Lu Yuzhen , Xu Jiajun , Olaniyi Ebenezer
Published: November 2022

Volume is an important phenotype and quality attribute of sweetpotato
storage roots. Conventionally the volume of most agricultural products
is measured by water displacement. This method, which requires
submerging the products in a container of water and measuring the
displacement of water in the container, is time-consuming and tedious.
It would be beneficial for sweetpotato breeding programs and quality
inspection if a rapid method is developed for measuring the volume of
sweetpotatoes. This study is therefore to evaluate the feasibility of
LiDAR (light detection and ranging) technology as a novel
high-throughput approach to phenotyping and measurement of the volume of
sweetpotatoes. LiDAR data will be acquired from sweetpotato storage
roots using a consumer-grade sensor, Intel® RealSense™ L515, which is an
RGB-D (red-green-blue-depth) camera. Ground-truth volume values will be
obtained using the reference water displacement method. RGB images will
be used to segment sweetpotatoes from background, and extract meaningful
features (e.g., the major axis length and the center of mass),
complement the point cloud data from depth images for volume estimation.
The shape of the sweetpotatoes will be constructed by a series of
three-dimensional coordinate points, the alpha shape method is to be
used to envelop the boundary points of sweetpotatoes to obtain a
non-convex body, and thereby the volume of the sweet potato will be
calculated. The efficacy of the proposed method will be evaluated in
terms of volume estimation accuracy.
Improved non-invasive root detection in soil using low noise magnetic resonance images
Authors: Pflugfelder Daniel , Koller Robert , Dusschoten Dagmar Van
Published: November 2022

Using magnetic resonance imaging (MRI), our established root phenotyping
platform (van Dusschoten et al., 2016) can visualize and analyze plant
roots in natural soil nondestructively (Pflugfelder et al., 2017). Using
plant pots with 9 cm diameter and 30cm height, a root system can be
scanned within 1h while roots down to diameters of 300µm can be detected
and analyzed using our in-house root extraction software NMRooting (van
Dusschoten et al., 2016). Thanks to automation with a pick-and-place
robot the platform routinely achieves a throughput of 24 plants per day.
All these values, however, are based on compromises between imaging
speed and quality. In our system, the root detection limit is determined
by the signal to noise ratio (SNR) of our images. The SNR can be
increased by using smaller plant pots or by increasing the imaging time.
In this contribution we investigate the potential gain in the root
detection limit when sacrificing plant throughput in favor of image
quality. We acquired low noise root images using repeated signal
averaging during the measurement process. Using this approach, the root
detection limit could be lowered, visualizing roots not detected by the
standard imaging protocol.
Use of machine vision to decipher the genetic basis of potato tuber characteristics in a tetraploid biparental linkage mapping population
Authors: Feldman Max , Park Jaebum , Feldman Max J , Miller Nathan , Wakholi Collins , Greene Katelyn , Abbasi Arash , Rippner Devin , Navarre Duroy , Schmitz-Carley Cari , Shannon Laura , Novy Rich
Published: November 2022

ORCiD: [ORCiD of presenting author] Jaebum Park
[0000-0001-6459-909X] AND/OR Max Feldman [0000-0002-5415-4326]

Tuber size and shape, colorimetric characteristics of tuber skin and
flesh, and tuber defect susceptibility are all factors that influence
the adoption of potato cultivars. Despite the importance of these
characteristics, our understanding of their inheritance is limited by
our inability to precisely measure these features on the scale needed to
evaluate breeding populations. To alleviate this bottleneck, we have
developed a low-cost, semi-automated workflow to capture data and
quantify each of these characteristics using machine vision. This
workflow was applied to assess the phenotypic variation present within
189 F1 progeny of the A08241 breeding population and map the genetic
basis of tuber characteristics. Several medium-to-large effect,
quantitative trait loci (QTL) were found to be associated with different
measurements of tuber shape. These results indicate that quantitative
measurements acquired using machine vision methods are reliable,
heritable, and can be used to map and select upon multiple traits
simultaneously in structured potato breeding populations.
Status of tryptophan metabolites in different stages of chronic kidney disease of non-diabetc etiology
Authors: Isakov Ivana , Cabarkapa Velibor , Srdjenovic-Conic Branislava , Kladar Nebojsa , Ilincic Branislava , Buric Dragan
Published: November 2022

Introduction. Modification of tryptophan metabolism during the progression of
chronic kidney disease may have significant pathophysiological consequences.
The aim of this study was to investigate the status of metabolic products of
tryptophan, indoxyl sulfate and kynurenine in different stages of chronic
kidney disease. Material and Methods. In all participants included in the
cross-sectional study (n = 66) with previously diagnosed chronic kidney
disease, the parameters of renal function were measured: glomerular
filtration rate using radionuclide plasma clearance with 99mTc-labelled
diethylene triamine penta-acetate and effective renal plasma flow using
131Ilabeled orthoiodohippuric acid. Plasma concentrations of indoxyl sulfate
and kynurenine were measured by high-performance liquid chromatography.
Results. A significant difference was observed in the concentrations of both
metabolites between the observed groups (Group II - measured glomerular
filtration rate - 15 - 60 ml/min/1.73 m?; n = 36 vs. Group I measured
glomerular filtration rate > 60 l/ min/1.73 m?; n = 26): indoxyl sulfate
1.07 ? 0.89 vs. 2.44 ? 4.05 ?g/ ml, p < 0.001; kynurenine 3.15 ? 0.22 vs.
3.21 ? 0.17 ?g/ml, p < 0.05. The correlation was statistically significant
between glomerular filtration rate and kynurenine - r = -0.38, p = 0.001 and
indoxyl sulfate - r = 0.56, p ? 0.001; effective plasma renal flow and
kynurenine - r = -0.33, p < 0.05 and indoxyl sulfate - r = 0.46, p ? 0.001.
Conclusion. There is a significant difference in the plasma concentrations
of indoxyl sulfate and kynurenine in the group of patients with glomerular
filtration rate of 15 - 60 ml/min/1.73 m? compared to patients with
glomerular filtration rate > 60 ml/min/1.73 m?. In patients with chronic
kidney disease, plasma concentrations of both metabolites of tryptophan are
inversely correlated with the glomerular filtration rate and effective
plasma renal flow.
Speech capacity in patients with voice disorders before and after surgical treatment of vocal fold tumors
Authors: Veselinovic Mila , Mitrovic Slobodan , Skrbic Renata , Milankov Vesela , Tamas Daniela
Published: November 2022

Inroduction. Pathological characteristics of voice and speech in persons with
benign and malignant vocal fold tumors present as different variations in
the voice pitch, intensity and quality. The aim of the study was to
determine the speech capacity of persons with malignant and benign vocal
fold tumors before and after surgical treatment and to establish if there
are differences in the speech capacity in relation to the type of tumor.
Material and Methods. The sample included 67 subjects who were divided into
two groups: group I - subjects with benign tumors, vocal cord lesions
(polyps, cysts) and Reinke?s edema and group II - subjects with malignant
tumors, aged 23 to 74 years (mean age 55.43; standard deviation 11.95).
Acoustic voice analysis, maximum phonation time of the vowel /a/, analysis
of temporal speech organization, and sentence melody analysis were used for
measuring the speech capacity. Results. Before surgery, the speech capacity
in both groups of patients was almost equal, without statistical
significance between the compared groups. After surgery, there was a
statistically significant difference between the speech capacity in the
examined groups, with better speech capacity observed in group I (t =
-3.807, p < 0.001). The study did not show an isolated effect of time or
tumor type on the speech capacity, but showed a combined effect (F = 10.079,
p = 0.002). Conclusion. The proposed method for the assessment of the speech
capacity before and after surgical treatment of vocal fold tumors is a
useful tool for the prediction of the voice outcome and in planning
rehabilitation procedures.
Malignant pleural effusion in patients with ovarian cancer
Authors: Maksimovic Tamara , Mandic Aljosa , Maksimovic Sinisa , Kuhajda Ivan , Bijelovic Milorad , Stevanovic Nemanja
Published: November 2022

Introduction. Ovarian cancer is the most lethal gynecological cancer. The
most common manifestation of thoracic metastasis is pleural effusion.
Pleural effusion with positive cytology is regarded as stage IVa of the
International Federation of Gynecology and Obstetrics classification, and
the overall five-year survival in these patients is less than 20%. We
analyzed the data of patients with ovarian cancer who were treated at the
Oncology Institue of Vojvodina, in order to establish the incidence of
malignant pleural effusions, laterality of pleural effusions, and clinical
manifestations. Material and Methods. The study included 731 patients with
ovarian cancer who were treated at the Oncology Institue of Vojvodina from
January 2012 to May 2020. The obtained data were compared with data found in
the literature in the same period. Results. The incidence of malignant
pleural effusion in our study was 5.75%; right-sided pleural effusion was
found in 57.15% of patients, 33.33% of patients had effusion on the left
side, and 9.52% had bilateral effusions. Thus, unilateral effusion was found
in 90.48% of cases, and bilateral in only 9.52%. The most common symptom was
dyspnea, reported in 33 patients (78.6%). Conclusion. The incidence of
malignant pleural effusion in our study was most similar to data found by
Zamboni et al. published in 2015; the right side was the dominant side of
pleural effusions. The most common symptoms were dyspnea, shortnes of breath
and chest pain.
Role and significance of tracheotomy in intensive care units in coronavirus disease 2019-positive patients
Authors: Djordjevic Ivan , Stojakov Dejan
Published: November 2022

Introduction. The role of tracheotomy in the treatment of patients with
prolonged intubation in intensive care units is known and confirmed. In
light of the global pandemic of severe acute respiratory syndrome
coronavirus-2 infection and consequent coronavirus disease 2019, we present
our experiences with tracheotomy in infected patients. Material and Methods.
A retrospective observational study of patients treated in intensive care
units at the Clinical Hospital Center ?Dr. Dragisa Misovic Dedinje? was
carried out in the period from March 21, 2020 to May 14, 2020. Results. A
total of 970 coronavirus disease 2019-positive patients were treated and out
of that number, 116 patients were treated in intensive care units (12%), of
which 49 patients (42%) were on non-invasive mechanical ventilation and 67
patients (58%) on intensive mechanical ventilation. The average age of the
patients was 59.3 years; the youngest patient was 46, and the oldest 73
years old. Tracheotomy was performed in 24 patients (21%), in 13 males
(54.1%) and 11 females (45.9%). The mean time from intubation to tracheotomy
was 11.6 days. Of the 24 tracheotomized patients, 12 had a successful
decannulation (50%) and were discharged from intensive care units, 6 had a
lethal outcome, and 6 patients were in treatment. Discussion. All the
patients underwent tracheotomy in the hospital room, because we considered
that any transfer and manipulation of these severe patients may lead to
worsening of the generally serious condition. Although some guidelines
recommend that it would be ideal to know the coronavirus disease 2019 status
before any invasive procedure, we believe that this is not necessary,
especially considering the clinical picture of patients during the pandemic,
as well as computed tomography findings in the lungs. Conclusion.
Tracheotomy has an important place in the treatment of patients with severe
coronavirus disease 2019 infection since it provides easier maintenance of
the airway, and in the recovery phase leads to easier transition of patients
from mechanical ventilation to spontaneous breathing. The decision on the
day when the tracheotomy will be performed is strictly individual and
depends on the general condition of the patient, and the use of
thermocautery does not affect the course of treatment and the final outcome.
Electrocardiographic features of patients with hypertrophic cardiomyopathy
Authors: Preveden Andrej , Usorac Mirna , Todic Mirko , Preveden Mihaela , Golubovic Miodrag , Velicki Lazar
Published: November 2022

Introduction. Hypertrophic cardiomyopathy is a disorder of the myocardium
characterized by asymmetric or symmetric left ventricular hypertrophy. It is
often an inherited disorder with an autosomal dominant pattern. The aim of
this study was to evaluate the electrocardiographic characteristics of
patients with hypertrophic cardiomyopathy, as well as to assess the accuracy
of current electrocardiographic criteria for left ventricular hypertrophy
used as indicators of hypertrophic cardiomyopathy. Material and Methods.
This retrospective study was conducted using hospital medical records of 42
patients with the diagnosis of hypertrophic cardiomyopathy. Detailed
electrocardiography analysis, apart from all the usual parameters, included
the calculation of indices used to diagnose left ventricular hypertrophy
including Sokolow augmented vector left, Cornell voltage, Cornell product,
and Sokolow-Lyon index. Results. Sinus rhythm was present in 95.2% of
patients, while atrial fibrillation was found in 4.8%. The majority of
patients presented with left axis deviation. A slight positive correlation
was found between the Sokolow augmented vector left index and posterolateral
wall thickness (r = 0.475; p < 0.05), and also between the Cornell voltage
index and posterolateral wall thickness (r = 0.368; p < 0.05). A borderline
positive correlation was found between the Cornell product index and
posterolateral wall thickness (r = 0.290; p = 0.063). Interventricular
septum thickness showed no significant correlation with any of the
electrocardiographic indices of left ventricular hypertrophy. Conclusion. In
patients with hypertrophic cardiomyopathy, the Sokolow augmented vector left
and Cornell voltage indices were the best indicators of posterolateral wall
hypertrophy, whereas none of the examined indices correlated well with the
interventricular septum thickness.
Saber-sheath trachea - a rare or underdiagnosed morphological variety of the trachea
Authors: Javorac Jovan , Zivanovic Dejan , Kasikovic-Lecic Svetlana , Ilic Miroslav , Milenkovic Ana , Cvetkovic Milos
Published: November 2022

Introduction. The saber-sheath trachea is characterized by widened
anteroposterior and narrowed laterolateral tracheal diameter. It is usually
found in patients with chronic obstructive pulmonary disease. The aim of
this study was to determine the incidence of this disorder, as well as to
gain insight into the basic socio-demographic characteristics of patients
and the clinical features of this tracheal deformity. Material and Methods.
Endoscopic findings of patients undergoing bronchoscopy at the Institute for
Pulmonary Diseases of Vojvodina in the period January 1, 2013 - January 1,
2021 were analyzed. Individual socio-demographic data of patients with the
diagnosis of saber-sheath trachea were collected and clinical parameters
were analyzed. Results. The analysis of 15.381 bronchoscopic findings showed
an incidence of 0.56%, most often in the elderly, predominantly in men, and
those who were active or former smokers. The most common comorbidities were
chronic obstructive pulmonary disease, cardiovascular diseases, and
diabetes. In all cases, this deformity was found as an incidental finding
during bronchoscopy that was mostly done for the diagnosis of primary
carcinoma of the bronchus. Accordingly, the most common pre-bronchoscopic
symptoms were shortness of breath, cough, and chest pain. No significant
narrowing of the tracheal lumen was found in any of the patients, nor did
this anatomical variety of the trachea affect the length of survival.
Conclusion. Although this is a rare disorder, its recognition can guide the
clinician to apply additional procedures in order to establish a diagnosis
of chronic obstructive pulmonary disease, but also significantly contribute
to avoiding potential complications in need of endotracheal intubation.