bluuebunny/crossref_metadata_2025 huggingface dataset:
Total Facelift: Forehead Lift, Midface Lift, and Neck Lift
Authors: Park Dong Man
Published: March 2015

Patients with thick skin mainly exhibit the aging processes of sagging, whereas patients with thin skin develop wrinkles or volume loss. Asian skin is usually thicker than that of Westerners; and thus, the sagging of skin due to aging, rather than wrinkling, is the chief problem to be addressed in Asians. Asian skin is also relatively large in area and thick, implying that the weight of tissue to be lifted is considerably heavier. These factors account for the difficulties in performing a facelift in Asians. Facelifts can be divided into forehead lift, midface lift, and lower face lift. These can be performed individually or with 2-3 procedures combined.
A Rabbit Model of Fat Graft Recipient Site Preconditioning Using External Negative Pressure
Authors: Lee Jung Woo , Han Yea Sik , Kim Sin Rak , Kim Han Kyeol , Kim Hyun , Park Jin Hyung
Published: March 2015

Background Fat is widely used in soft tissue augmentation. Nevertheless, it has an unpredictably high resorption rate. Clinically, external expansion with negative pressure is used to increase fat graft survival. In this study, fat graft recipient sites were preconditioned by external application of negative pressure in order to test for improvements in vascularity and fat graft survival.

Methods Negative pressure was applied randomly to either the left or right dorsal ear of 20 New Zealand male white rabbits at a pressure of -125 mm Hg. The negative pressure was removed one week after the skin perfusion was measured. The skin flap at each ear was elevated, and 1 g of fat was grafted above the dorsal perichondrium. After one week, the fat weight, microvessel density, mature vessel density of the skin and fat, and amount of glycerol released were measured. Three months after the grafting, the same measurements were performed, with the exception of glycerol release.

Results The fat survival rate of the experimental group (75.4%±3.9%) was higher than that of the control group (53.1%±4.3%) (P<0.001). Skin perfusion was higher in the experimental group. The glycerol release in the experimental group was significantly higher than in the control. The microvessel density of the skin and fat was significantly higher in the experimental group. Three months after the grafting, the skin and fat mature vessel density was significantly higher in the experimental groups.

Conclusions Negative pressure prior to fat grafting increased the vascularity of the recipient site, and, accordingly, enhanced fat graft survival.
Retrospective Analysis of the One-per-Million Tumescent Technique in Post-Burn Hand Deformity Surgeries
Authors: Prasetyono Theddeus OH , Koswara Astrid Felicia
Published: March 2015

Background The use of a tourniquet in hand surgery is generally accepted as necessary to create a clear visualization of the operative field. This study aims to determine the effectiveness of one-per-million tumescent solution (1:1,000,000 epinephrine concentration) in creating a bloodless operative field in post-burn hand deformity surgeries performed without a tourniquet.

Methods This retrospective observational study was conducted on a series of 12 patients with post-burn hand deformities who underwent surgery between February 2013 and January 2014. A total of 29 operative fields were recorded. The one-per-million tumescent solution was used for hemostatis instead of a tourniquet. The clarity of the operative field, volume of solution injected, duration of surgery, scar thickness and density, and functional outcomes at least three months after the surgery were observed. The relationship of scar thickness and density with the clarity of the operative field was analyzed with the chi-square test.

Results Of the 29 operative fields in which the one-per-million tumescent technique was used, 48.2% were totally bloodless, 44.8% had minimal bleeding, and 6.9% had an acceptable level of bleeding. Both scar thickness and density were shown to have a significant relationship with operative field clarity (P<0.05).

Conclusions The one-per-million tumescent technique is effective in facilitating post-burn hand deformity surgeries involving meticulous, multiple, and lengthy procedures by creating a relatively clear operative field without the use of a tourniquet. Although scar thickness and density are associated with the clarity of the operative field, this technique can be considered safe and effective in creating a clear operative field.
Early Intervention for Low-Temperature Burns: Comparison between Early and Late Hospital Visit Patients
Authors: Choi Matthew Seung Suk , Lee Ho Joon , Lee Jang Hyun
Published: March 2015

Background Various focal heating devices are popular in Korea under the cultural influence of the traditional ondol under-floor method of home heating. These devices can cause severe burn-like injuries resulting from device malfunction or extended with low heat contact. In addition to injuries under these high heat contact, burns can be occurred by low heat exposure with prolonged periods despite the devices are properly functioning. In order to develop strategies to reduce the duration of periods of illness due to low-temperature burns, we analyzed and compared treatment methods and therapeutic periods for this type of injury.

Methods This retrospective study included 43 patients burned under low heat conditions. Patients were divided into an operative group and a conservative group. The patients in the operative group underwent at least one surgical excision, and were further subdivided into early and late visit groups. The conservative group was treated only with dressings. We compared the treatment periods between the operative group and the conservative group, and also compared the preparation periods and treatment periods between the two operative groups.

Results The average treatment period was significantly shorter in the operative group (P=0.02). In the early visit operative group, both wound preparation and treatment were briefer than in the late visit group.

Conclusions We recommend that early proper burn care and early surgical intervention, including appropriate excision, are feasible ways to reduce the treatment period of low-temperature burn patients.
The Preventive Effect of Topical Zafirlukast Instillation for Peri-Implant Capsule Formation in Rabbits
Authors: Kang Shin Hyuk , Shin Kee Cheol , Kim Woo Seob , Bae Tae Hui , Kim Han Koo , Kim Mi Kyung
Published: March 2015

Background Capsular contracture is the most troublesome complication in breast implant surgery. Although capsule formation can be seen as a normal reaction to a foreign body, it can induce pain, hardness, deformity, and other pathologic problems. Surgical intervention is required in severe cases, but even surgery cannot guarantee a successful outcome without recurrence. This experimental study confirms that single topical administration of leukotriene antagonist zafirlukast (Accolate, Astrazeneca) reduces peri-implant capsule formation and prevents capsular contracture.

Methods Twelve smooth-surfaced cohesive gel implants were implanted in New Zealand White rabbits. These miniature implants were designed to be identical to currently used products for breast augmentation. The rabbits were divided into 2 groups. In the experimental group (n=6), the implant and normal saline with zafirlukast were inserted in the submuscular pocket. In the control group (n=6), the implant and normal saline alone were used. Two months later, the implants with peri-implant capsule were excised. We evaluated capsule thickness and collagen pattern and performed immunohistochemical staining of myofibroblasts, transforming growth factor (TGF)-β1, 2.

Results The thickness of the capsules in the experimental group was reduced in both dorsal and ventral directions. The collagen pattern showed parallel alignment with low density, and the number of myofibroblasts as well as the amounts of TGF-β1 and TGF-β2 were reduced in the experimental group.

Conclusions We suggest that single topical administration of leukotriene antagonist zafirlukast can be helpful in reducing capsule formation and preventing capsular contracture via myofibroblast suppression, modulation of fibroblastic cytokines, and anti-inflammatory effect.
Non-Melanocytic Benign Tumors of the Face: A Retrospective Study
Authors: Lee Kyoung Min , Lim Jung Soo , Min Kyung Hee , Lee Jong Hun , Hong Sung Hee , Lee Hye Kyung
Published: March 2015

Background Although plastic surgeons daily encounter various facial tumors in the field, reports limited on face are scarce. In our study, we want to provide basic epidemiologic data to help clinicians to decide the proper management for their patients.

Methods We retrospectively reviewed the medical records of patients including age and gender, location and size of the tumor, histopathologic result, recurrence, type of anesthesia and any associated disorders who had undergone a surgical removal of their facial tumors and received the histopathologic report in the same institution between January 2009 and October 2012.

Results One hundred eighty-nine patients with 203 non-melanocytic benign tumors were included. The most frequent site of tumors was the central subunit of the forehead, followed by the lateral subunit of the cheek and the auricular unit. Of 36 different histopathologic results, the epidermal cyst was most frequent, followed by lipoma, pilomatricoma and osteoma. Statistical analysis showed that males were dominant in the epidermal cyst and lipoma groups. While, females were dominant in the osteoma and pilomatricoma groups. No associations were found between lesions and other diseases.

Conclusions Our study is the at most specific and concentrated study on non-melanocytic benign tumors of the face. We expect the epidemiologic data of our study may help plastic surgeons who are confronted with so many facial lesions in the field to decide on the most proper management for their patients.
Treatment of Eyelid Ptosis due to Kearns-Sayre Syndrome Using Frontalis Suspension
Authors: Weitgasser Laurenz , Wechselberger Gottfried , Ensat Florian , Kaplan Rene , Hladik Michaela
Published: March 2015

Blepharoptosis is a common indication for surgery in plastic surgery units, yet its possible underlying pathology frequently remains unidentified. A 52-year-old man with a 20-year history of progressive bilateral ptosis (right>left) presented with recurrent ptosis of both eyes; he had undergone an operation on the levator aponeurosis 12 years prior. Due to the suspicion of an underlying disease, he was evaluated further. Chronic progressive external ophthalmoplegia in transition to the more severe syndromic variant Kearns-Sayre syndrome, a mitochondrial disorder causing myopathy, was diagnosed. The patient was treated with coenzyme Q10, and he underwent ptosis surgery on both eyes. This case illustrates a potentially multi-systemic disease that was diagnosed by a further evaluation of a common symptom, in this case worsening blepharoptosis. Awareness of myopathic symptoms is necessary to prevent overlooking serious yet improvable conditions.
Preterm premature rupture of membranes at 32–34 weeks of gestation: duration of membrane rupture period and maternal blood indicators relation with congenital infection
Authors: Daunoravičienė Ieva , Lenkutienė Rūta , Musteikytė Audrė , Ramašauskaitė Diana
Published: March 2015

Background. The study investigates the influence of the length of membrane rupture period among pregnant women with preterm premature rupture of membranes (PPROM) between the 32nd and 34th weeks of gestation on the development of chorioamnionitis and the congenital infection of a newborn. It seeks to ascertain the values of indicators in mother’s blood that enable to predict chorioamnionitis and funisitis for mothers, and congenital infection for newborns.
Materials and methods. A retrospective study of case records of women with PPROM at 32 (32 w. + 0 d)–34 (33 w. + 6 d) weeks of gestation and their newborns was performed. Two comparative groups were made: 1) of women who had funisitis and / or chorioamnionitis with or without deciduitis and 2) of women having no proved inflammation (according to the results of histological examination of placentae). Analogically, comparative groups were made of their newborns: those who had diagnosis of congenital infection and those who had no infection. The duration of membrane rupture period and the blood markers were investigated in all the groups.
Results. The study included 135 women. Duration of the membrane rupture period lasted 85.17 ± 84.72 hrs in the group of women who had histological inflammation, and 40.06 ± 56.57 hrs in the group with no inflammation, P = 0.01, AUC = 0.735; the critical membrane rupture period value for developing intrauterine infection by the Youden index was 43.7 hrs. The corresponding maternal CRP values (mg/l) were 25.85 ± 40.27 vs. 5.23 ± 7.88 (P = 0.01, AUC = 0.6), the Youden index 4.6 mg/l. For the mothers of the newborns diagnosed with infection, the duration of the membrane rupture period was 55.95 ± 65.04 hrs, for the mothers of the newborns without congenital infection it was 40.25 ± 73.71 hours. Respectively, CRP values for the mothers of newborns averaged 12.25  ±  22.14  mg/l vs. 4.8 ± 4.82 mg/l (P = 0.005).
Conclusions. Longer membrane rupture period and higher maternal CRP are correlated with inflammatory changes in the placenta and umbilical cord, thus they can be used as the prognostic indicators of intrauterine infection. When the duration of the membrane rupture period lasts ≥44 hrs, the risk of chorioamnionitis and funisitis increases five times; when the maternal serum CRP is higher than 5 mg/l, funisitis / chorioamnionitis is twice more frequent than at lower than 5 mg/l CRP values.
First experience of salvage HDR brachytherapy after prostate cancer radiotherapy
Authors: Kišonas Juras , Burneckis Arvydas , Ivanauskas Andrius , Mickevičius Romualdas , Vėželis Alvydas
Published: March 2015

Introduction. Prostate cancer (PC) is the most common oncologic disease among men. The number of patients with recurrent PC after primary radiotherapy is increasing, unfortunately, criteria for the choice among different treatment methods for these patients have not been defined yet. Salvage treatment options include prostatectomy, brachytherapy (BT), cryotherapy, thermoablation, and high frequency ultrasound. The lack of long-term evaluation of the toxicity and influence on the survival of patients after salvage high-dose-rate (HDR) BT is an important problem when considering this treatment option. In this study we have analyzed the treatment results of twelve patients who were diagnosed with local recurrent prostate cancer after primary radiotherapy and then treated with HDR BT.
Materials and methods. Patients were treated with salvage HDR BT between January 2013 and February 2014 at the Institute of Oncology, Vilnius University
Results. Average age of the patients at the time of salvage treatment was 67.5 years (min 54 years, max 76 years). The PSA value at the salvage treatment was from 2.06 ng/ml to 9.20 ng/ml. The time from the initial diagnosis till the salvage treatment was from 33 months to 134 months. All 24 procedures were successful and without any early complications.
Conclusions. HDR BT is a presumable and safe treatment option for local prostate cancer recurrence after primary radiotherapy. Prospective clinical trial is initiated to evaluate survival, long-term toxicity and predictive value of different biomarkers.
Renforcer l’auto-efficacité entrepreneuriale des étudiants par des modèles de rôle d’anciens ayant réussi ou échoué
Authors: Brunel1 Olivier , Laviolette Éric Michael , Radu Lefebvre Miruna
Published: March 2015

À partir d’une modélisation structurelle, cette recherche expérimentale menée sur 276 étudiants permet de mesurer l’impact des modèles de rôles entrepreneuriaux sur leur auto-efficacité et leur intention de créer une entreprise. Nos résultats confirment que l’exposition des participants au message d’un ancien étudiant ayant réussi dans sa carrière entrepreneuriale engendre un éveil émotionnel positif et une attitude favorable envers le message, améliorant l’auto-efficacité et l’intention entrepreneuriale des participants. Pour certains participants, les modèles d’échec sont également efficaces d’un point de vue persuasif, renforçant la relation entre auto-efficacité et intention entrepreneuriale. Par ailleurs, cette recherche démontre que le cadrage du message et l’encouragement verbal d’un membre de l’équipe pédagogique avant l’exposition au message exercent un effet modérateur et parfois paradoxal sur ces résultats selon le sexe de l’étudiant. Nous discutons ces effets en relativisant l’intervention des membres de l’équipe pédagogique dans l’impact des modèles de rôles entrepreneuriaux.
La influencia de la Comisión Pastoral de la Tierra (CPT) en la formación del Movimiento de los Trabajadores Rurales Sin Tierra (MST): breve análisis teórico-documental del papel de la religión en los conflictos sociales en Brasil (1954-1984)
Authors: Pinto Lucas Henrique
Published: March 2015

This article seeks to relate the influence of the Pastoral Land Commission with its ties to Liberation Theology in. organizing the Landless Rural Workers of Brazil in 1984. That ecclesial model was one of the basic variables in the constitution of said social movement and its distinctive scale of national representation and socio-political coordination, which was to influence the methodology of rural collective action in Latin America in the decades that followed. The aim of the present project is thus to situate the debate regarding the agrarian issue in Brazilia during the military dictatorship, emphasizing the role of the Catholic Church in the process.
Indigenismo de derecha. La formación de la OPIC como “revolución pasiva”
Authors: Ramírez Carlos Andrés
Published: March 2015

In March 2009 an indigenous organization called the OPIC (Pluricultural Organization of the Indigenous Peoples of Cauca) appeared in Colombia whose political position differed drastically from that of the country´s mainstream indigenous organizations since it openly endorsed the government of Álvaro Uribe. As noted immediately by some journalists and political analysts, it was believed to have been the result of a government strategy to create a division in one sector of the opposition. Such an explanation, however, is reductionist. This article aims to show, by taking advantage both of Gramsci’s notion of “passive revolution” and of some features of Discourse Analysis, how the rise of the OPIC was also due to a process of ideological identification of a sector of the indigenous population of Cauca that had deep historical roots in Evangelicalism with the politics of Uribismo. The paper thus seeks to show to what extent it is possible to talk about a right-wing indigenous movement in Colombia based on an understanding of the political dimension of religion and contrary to those who consider the rise of the OPIC to be simply the result of a divisionist and clientelist strategy employed by the Uribe government.
Escenarios del trabajo, una aproximación a la heterogeneidad del trabajo contemporáneo en Latinoamérica
Authors: Soto Roy Álvaro
Published: March 2015

This paper proposes a model for characterize-ing and analyzing workspaces in contemporary Latin American organizations that seeks to portray the heterogeneous forms in which the activity of work unfolds in a single social and productive space. This model may be relevant for different types of social studies of work insofar as it sheds light on the structural characteristics that account for different social and subjective processes. It proposes the notion of work scenarios, understood as typical labor configurations where certain ways of organizing work and employment and human management practices converge which reflect the basic contribution that is expected of workers by the organization, and the type of relation the organization offers in return. In addition to proposing analytical criteria and methodological approach strategies, the paper describes a qualitative research experience that tested the notion of work scenarios as a result of which six scenarios were identified that provided cross-section of important sectors of the Chilean economy.
Heterotopic Pancreatic Pseudocyst Radiologically Mimicking Gastrointestinal Stromal Tumor
Authors: Sarsenov Dauren , Tırnaksız Mehmet Bülent , Doğrul Ahmet Bülent , Tanas Özlem , Gedikoglu Gökhan , Abbasoğlu Osman
Published: March 2015

Heterotopic pancreas is a relatively common variant of foregut embryologic dystopia that can be described as pancreatic tissue found outside the normal anatomic location, being independent from vascular supply of normal pancreas. Having all features of pancreatic tissue except for the major duct structures, this ectopic tissue may be clinically recognized when pathologic changes take place. Inflammation, hemorrhagic or obstructive states, and eventually malignancy-related problems may become a diagnostic challenge for clinician and finally lead to consequences of misdiagnosis. In this article we will discuss a case of heterotopic pancreatic tissue located in gastric cardia, which was diagnosed preoperatively as gastrointestinal stromal tumor.
Laparoscopic Sigmoid Colectomy for a Patient With Sigmoid Colon Cancer and Crossed-Fused Renal Ectopia: A Case Report
Authors: Nakai Nozomu , Yamaguchi Tomohiro , Kinugasa Yusuke , Shiomi Akio , Tomioka Hiroyuki , Kagawa Hiroyasu , Yamakawa Yushi , Sato Sumito
Published: March 2015

Crossed-fused renal ectopia (CFRE) is a very rare congenital renal malformation. This condition comprises several anatomic anomalies, including unilateral ureteral intersection of the midline, anteriorly-placed renal pelvises, and aberrant renal blood vessels, all of which increase the difficulty of colectomy. This report describes a case of laparoscopic sigmoidectomy with sufficient lymphadenectomy for a patient with sigmoid colon cancer and left-sided L-shaped CFRE. Preoperative computed tomography demonstrated that the origin of the inferior mesenteric artery (IMA) was free from anomalies and that the tumor did not invade surrounding organs. Therefore, we planned conventional laparoscopic sigmoid colectomy with D3 lymphadenectomy. Division of IMA at its origin and anterior colon resection was successfully performed by careful mobilization of the mesocolon to avoid exposing the retroperitoneal organs. To our knowledge, this is the first case report of laparoscopic colectomy for a patient with CFRE. Sufficient preoperative assessment of anatomic anomalies enabled successful surgery.
Cutaneous Metastases From Esophageal Adenocarcinoma
Authors: Triantafyllou Stamatina , Georgia Doulami , Gavriella-Zoi Vrakopoulou , Dimitrios Mpistarakis , Stulianos Katsaragakis , Theodoros Liakakos , Georgios Zografos , Dimitrios Theodorou
Published: March 2015

The aim of this study is to present 2 rare cases of cutaneous metastases originated from adenocarcinoma of the gastro-esophageal junction, thus, underline the need for early diagnosis and possible treatment of suspicious skin lesions among patients with esophageal malignancy. Metastatic cancer to the skin originated from internal malignancies, mostly lung cancer, breast cancer, and colorectal cancer, constitute 0.5 to 9% of all metastatic cancers.5,8,15 Skin metastases, mainly from squamous cell carcinomas of the esophagus, are rarely reported. Cutaneous metastasis is a finding indicating progressiveness of the disease.17 More precisely, median survival is estimated approximately 4.7 months.2,14 This study is a retrospective review of 2 cases of patients with adenocarcinoma of the esophagus and a review of the literature. Two patients aged 60 and 32 years old, respectively, underwent esophagectomy. Both pathologic reports disclosed adenocarcinoma of the gastro-esophageal junction staged T3 N2 M0 (stage IIIB). During follow-up time, the 2 patients were diagnosed with cutaneous metastases originated from the primary esophageal tumor 11 and 4 months after surgery, respectively. The first patient is alive 37 months after diagnosis, while the second one died 16 months after surgery. Cutaneous metastasis caused by esophageal adenocarcinoma is possible. Therefore, follow-up of patients who were diagnosed with esophageal malignancy and underwent esophagectomy is mandatory in order to reveal early surgical stages.
Differentiated Thyroid Cancer With Liver Metastases: Lessons Learned From Managing a Series of 14 Patients
Authors: Brient C. , Mucci S. , Taïeb D. , Mathonnet M. , Menegaux F. , Mirallié E. , Meyer P. , Sebag F. , Triponez F. , Hamy A.
Published: March 2015

Liver metastases from differentiated thyroid carcinoma (LMDTC) are rare and usually occur in disseminated metastatic disease. The aim of this study was to review the diagnosis and management of LMDTC. Between 1995 and 2011, 14 patients with a mean age of 59.7 years (+/-10.2) were treated for LMDTC. Data were retrospectively reviewed and analyzed. Seven patients had distant metastases at diagnosis, including 2 with synchronous liver lesions. The average time of onset of LMDTC from initial diagnosis was 52.2 months (+/49.5). All LMDTC were discovered during routine radiologic monitoring. Histologic analysis confirmed LMDTC in 5 patients. Eight patients received tyrosine kinase inhibitors, 1 patient underwent resection of their LMDTC after chemotherapy. Six patients (disseminated metastases, significant comorbidities) did not receive any specific treatment. The median survival after diagnosis of LMDTC was 17.4 months (+/-3.3): 23.6 months (+/-2.9) for patients who underwent chemotherapy versus 3.9 months (+/-0.9) for patients who did not receive any specific treatment (P < 0.001). Developing DTC liver metastasis is a very poor prognostic sign. Chemotherapy by TKIs, especially, hold promise in the cure of LMDTC for selected patients.
Temporary Diverting Ileostomy via the Umbilicus: a Small Case Series
Authors: Mushaya C. D. , Chandra Raaj , Sansom Wendy , Keck James
Published: March 2015

The umbilicus, a natural orifice, which is used as an access port during laparoscopic surgery, can be used as a stoma site with potential superior cosmetic results as one less incision is then required. Our objective was to assess the efficacy and safety of the umbilical stoma in a selected group of patients. This is a prospective case series in hospital patients admitted as emergency or elective. Patients who underwent laparoscopic colorectal surgery with a planned ileostomy at Box Hill Hospital were approached and invited to participate in the study, with the stoma being fashioned on the umbilicus. Outcomes of interest included demographics, the details regarding the original indication for operation, operative and hospital related outcomes, postoperative bowel related complications, and other surgical and medical complications. Outcomes of a total of 10 (5 males) patients who underwent umbilical covering ileostomy during the study period were analyzed. Two patients with ulcerative colitis had the second stage of their operation converting their end stomas to loop stoma. These were counted twice, totaling 12 stomas in 10 patients. Three patients had their umbistomas after receiving neoadjuvant treatment for rectal cancer. The median period patients have had umbistomas is 113 days. Overall morbidity during the initial operation was low, except for 1 patient who had a small bowel injury. There was no mortality. Minor peristomal skin changes were the most common postoperative complication. Three patients had their stomas reversed with excellent cosmesis. Umbistomas appear to be a safe and effective way to fashion covering stomas post laparoscopic surgery and save the patient an added incision with excellent cosmetic results.
Predictions of the highest potential transmissivity of fractures in fault zones from rock rheology: Preliminary results
Authors: Ishii Eiichi
Published: March 2015

Fracture transmissivity in a fault zone is a significant parameter when solving certain geoscientific and geotechnical problems. However, the transmissivities are difficult to predict quantitatively owing to the complexity of in situ conditions such as the apertures of fractures. This study analyzes extensive data sets on flow anomalies (transmissive zones) detected from fluid/flow logs of boreholes in fault zones in the light of rock rheology, fracture mineralization/dissolution, and fracture orientation at six sites, namely Horonobe (Japan; siliceous mudstone), Wellenberg (Switzerland; argillaceous marl), Forsmark (Sweden; granite/granodiorite), Olkiluoto (Finland; gneiss), Northern Switzerland (granite/gneiss), and Sellafield (UK; volcaniclastic rocks and sandstone). The flow anomalies are correlated to fractures in fault zones. The data sets show that the transmissivities of the flow anomalies are strongly controlled by the ductility index, defined as the effective mean stress normalized to the tensile strength of the intact rock. An empirically derived power law relationship exists between the transmissivity and the ductility index, allowing predictions of the highest potential transmissivities of fractures in possible fault zones with maximum errors of about 2 orders of magnitude, due to the inevitable heterogeneity of a fault zone. The actual transmissivities may be further reduced by mineral precipitation in the fractures, or increased by mineral dissolution. Fracture orientation has no discernable influence on the transmissivity. The results may prove helpful for understanding and predicting the long‐term transport properties of fault zones in the upper crust.
Climate response to externally mixed black carbon as a function of altitude
Authors: Samset B. H. , Myhre G.
Published: March 2015

The climate response to the presence of black carbon (BC) aerosol at a given altitude in the atmosphere is investigated using a global circulation model. The vertical dependence of the efficiency with which BC exerts radiative forcing (RF) through the direct aerosol effect has previously been extensively studied. Here we use the Community Atmosphere Model version 4 atmospheric component of the National Center for Atmospheric Research Community Earth System model version 1.03 to calculate the three‐dimensional response to a BC layer inserted at various altitudes. Simulations have been performed both for fixed sea surface temperatures and using a slab ocean setup to include the surface temperature response. We investigate the vertical profiles of RF exerted per gram of externally mixed BC due to both the direct and semidirect aerosol effects. Associated changes in cloud cover, relative humidity, and precipitation are discussed. The precipitation response to BC is decomposed into a fast, stability‐related change and a slow, temperature‐driven component. We find that while the efficiency of BC to exert positive RF due to the direct effect strengthens with altitude, as in previous studies, it is strongly offset by a negative semidirect effect. The net radiative perturbation of BC at top of atmosphere is found to be positive everywhere below the tropopause and negative above. The global, annual mean precipitation response to BC, after equilibration of a slab ocean, is found to be positive between the surface and 900 hPa but negative at all other altitudes.
Evapotranspiration based on equilibrated relative humidity (ETRHEQ): Evaluation over the continental U.S.
Authors: Rigden Angela J. , Salvucci Guido D.
Published: March 2015

A novel method of estimating evapotranspiration (ET), referred to as the ETRHEQ method, is further developed, validated, and applied across the U.S. from 1961 to 2010. The ETRHEQ method estimates the surface conductance to water vapor transport, which is the key rate‐limiting parameter of typical ET models, by choosing the surface conductance that minimizes the vertical variance of the calculated relative humidity profile averaged over the day. The ETRHEQ method, which was previously tested at five AmeriFlux sites, is modified for use at common weather stations and further validated at 20 AmeriFlux sites that span a wide range of climates and limiting factors. Averaged across all sites, the daily latent heat flux RMSE is ∼26 W·m−2 (or 15%). The method is applied across the U.S. at 305 weather stations and spatially interpolated using ANUSPLIN software. Gridded annual mean ETRHEQ ET estimates are compared with four data sets, including water balance‐derived ET, machine‐learning ET estimates based on FLUXNET data, North American Land Data Assimilation System project phase 2 ET, and a benchmark product that integrates 14 global ET data sets, with RMSEs ranging from 8.7 to 12.5 cm·yr−1. The ETRHEQ method relies only on data measured at weather stations, an estimate of vegetation height derived from land cover maps, and an estimate of soil thermal inertia. These data requirements allow it to have greater spatial coverage than direct measurements, greater historical coverage than satellite methods, significantly less parameter specification than most land surface models, and no requirement for calibration.
Volume of Martian midlatitude glaciers from radar observations and ice flow modeling
Authors: Karlsson N. B. , Schmidt L. S. , Hvidberg C. S.
Published: March 2015

Numerous glacier‐like forms have been identified in the midlatitudes of Mars, and within recent years the acquisition of radar sounding data has revealed that the features are chiefly composed of water ice. Here we use radar observations in combination with ice flow models and inverse methods to calculate the volume of ice present at the midlatitudes of Mars. In order to obtain ice thicknesses, we infer the yield stress of the ice deposits, and we find that they are consistently lower than those of most terrestrial glaciers. We estimate the present ice volume of lobate debris aprons (identified by Levy et al. (2014)) on Mars to correspond to 1.55 · 105 km3 with an uncertainty of 25%. This corresponds to a global ice cover of 1.1m. Thus, the water ice found at midlatitudes is an important water reservoir, and an important part of the global surface ice budget.
Estimates of Lagrangian transport by surface gravity wave groups: The effects of finite depth and directionality
Authors: van den Bremer T. S. , Taylor P. H.
Published: March 2015

Two physical phenomena drive the Lagrangian trajectories of neutrally buoyant particles underneath surface gravity wave groups: the Stokes drift results in a net displacement of particles in the direction of propagation of the group, whereas the Eulerian return flow transports such particles in the opposite direction. Generally, the Stokes drift is the larger of the two near the surface, whereas the effects of the return flow dominate at depth. A transition depth can be defined that separates the two regimes. Using a multiple‐scales expansion, we provide leading‐order estimates of the forward transport, the backward transport, and the transition depth for realistic sea states. We consider the effects of both finite depth and the directionally spread nature of the waves on our estimates. We show that from the perspective of the return flow, almost all seas are of finite depth. In fact, many seas can be shown to be “shallow” from the perspective of the return flow with little variation of this flow with depth. Furthermore, even small degrees of directional spreading can considerably reduce the magnitude of the return flow and its transport.
The association between childhood maltreatment, mental health problems, and aggression in justice‐involved boys
Authors: Hoeve Machteld , Colins Olivier F. , Mulder Eva A. , Loeber Rolf , Stams Geert Jan J. M. , Vermeiren Robert R. J. M.
Published: March 2015

The link between childhood maltreatment and adolescent aggression is well documented; yet, studies examining potential mechanisms that explain this association are limited. In the present study, we tested the association between childhood maltreatment and adolescent aggression in boys in juvenile justice facilities (N = 767) and examined the contribution of mental health problems to this relationship. Data on childhood maltreatment, mental health problems, and aggression were collected by means of self‐report measures and structural equation models were used to test mediation models. We found that mental health problems mediated the link between maltreatment and aggression. Results demonstrated different pathways depending on the type of aggression examined. The association between childhood maltreatment and reactive aggression was fully mediated by a variety of mental health problems and for proactive aggression the association was partially mediated by mental health problems. We also found that reactive and proactive aggression partially mediated the association between maltreatment and mental health problems. These findings suggest that a transactional model may best explain the negative effects of childhood trauma on mental health problems and (in particular reactive) aggression. In addition, our findings add to the existing evidence that reactive and proactive aggression have different etiological pathways. Aggr. Behav. 41:488–501, 2015. © 2015 Wiley Periodicals, Inc.
Colorimetric Logic Gates Based on Poly(2‐alkyl‐2‐oxazoline)‐Coated Gold Nanoparticles
Authors: de la Rosa Victor R. , Zhang Zhiyue , De Geest Bruno G. , Hoogenboom Richard
Published: March 2015

A straightforward end‐capping strategy is applied to synthesize xanthate‐functional poly(2‐alkyl‐2‐oxazoline)s (PAOx) that enable gold nanoparticle functionalization by a direct “grafting to” approach with citrate‐stabilized gold nanoparticles (AuNPs). Owing to the presence of remaining citrate groups, the obtained PAOx@AuNPs exhibit dual stabilization by repulsive electrostatic and steric interactions giving access to water soluble molecular AND logic gates, wherein environmental temperature and ionic strength constitute the input signals, and the solution color the output signal. The temperature input value could be tuned by variation of the PAOx polymer composition, from 22 °C for poly(2‐npropyl‐2‐oxazoline)@AuNPs to 85 °C for poly(2‐ethyl‐2‐oxazoline)@AuNPs. Besides, advancing the fascinating field of molecular logic gates, the present research offers a facile strategy for the synthesis of PAOx@AuNPs of interest in fields spanning nanotechnology and biomedical sciences. In addition, the functionalization of PAOx with xanthate offers straightforward access to thiol‐functional PAOx of high interest in polymer science.
Metal‐Organic Framework Nanofilm for Mechanically Flexible Information Storage Applications
Authors: Pan Liang , Ji Zhenghui , Yi Xiaohui , Zhu Xiaojian , Chen Xinxin , Shang Jie , Liu Gang , Li Run‐Wei
Published: March 2015

Metal‐organic frameworks (MOFs), which are formed by association of metal cations or clusters of cations (“nodes”) with soft organic bridging ligands (“linkers”), are a fascinating class of flexible crystalline hybrid materials offering potential strategy for the construction of flexible electronics. In this study, a high‐quality MOF nanofilm, HKUST‐1, on flexible gold‐coated polyethylene terephthalate substrates is fabricated using liquid phase epitaxy approach. Uniform and reproducible resistive switching effect, which can be sustained under the strain of as high as 2.8%, and over the wide temperature range of –70 to +70 °C, is observed for the first time in the all solid‐state Au/HKUST‐1/Au/thin film structures. Through conductive atomic force microscopic and depth‐profiling X‐ray photoelectron spectroscopicanalysis, it is proposed that the electric field‐induced migration of the Cu­2+ ions, which may lead to subsequent pyrolysis of the trimesic acid linkers and thus the formation of highly conducting filaments, could be the possible origin for the observed uniform resistance switching in HKUST‐1 nanofilms.
Strong IR NLO Material Ba4MGa4Se10Cl2: Highly Improved Laser Damage Threshold via Dual Ion Substitution Synergy
Authors: Li Yan‐Yan , Liu Peng‐Fei , Hu Lei , Chen Ling , Lin Hua , Zhou Liu‐Jiang , Wu Li‐Ming
Published: March 2015

Infrared nonlinear optical (IR NLO) materials are the key materials in the modern laser frequency conversion technology that are widely applied in many fields. Yet, the major issue is lacking of high performance materials with large nonlinear susceptibility and high laser damage threshold, which are two correlated and contradictory parameters. Here, the novel dual ion substitution synergy leads to the discovery of Ba4MGa4Se10Cl2 (M = Zn, 1; Cd, 2; Mn, 3; Cu/Ga, 4; Co, 5; and Fe, 6), crystallizing in the tetragonal . Polycrystalline 1–4 exhibits very strong IR second harmonic generations (SHG). (1: 59×; 2: 52×; 4: 39×; and 3: 30× that of IR benchmark NLO material AgGaS2). Remarkably, the laser‐induced damage threshold of 1 is 143.6 MW cm–2, roughly 17 times that of benchmark AgGaS2. These distinguish 1 as a new promising NLO material. In addition, 1, 2, and 4 illustrate the coexistence of NLO and photoluminescence properties. Especially, 3 demonstrate for the first time the coexistence of triple properties (NLO, photoluminescence, and magnetism) in a single crystal structure. The insights of the driving force of the synergetic substitution, SHG origin, and microscopic contributions of the building units open a new route to discovering novel multi‐functional NLO materials.
Replication of 13q31.1 association in nonsyndromic cleft lip with cleft palate in Europeans
Authors: Jia Zhonglin , Leslie Elizabeth J. , Cooper Margaret E. , Butali Azeez , Standley Jennifer , Rigdon Jennifer , Suzuki Satoshi , Gongorjav Ayana , Shonkhuuz T. Enkhtur , Natsume Nagato , Shi Bing , Marazita Mary L. , Murray Jeffrey C.
Published: March 2015

Genome wide association (GWA) studies have successfully identified at least a dozen loci associated with orofacial clefts. However, these signals may be unique to specific populations and require replication to validate and extend findings as a prelude to etiologic SNP discovery. We attempted to replicate the findings of a recent meta‐analysis of orofacial cleft GWA studies using four different ancestral populations. We studied 946 pedigrees (3,436 persons) of European (US white and Danish) and Asian (Japanese and Mongolian) origin. We genotyped six SNPs that represented the most significant P‐value associations identified in published studies: rs742071 (1p36), rs7590268 (2p21), rs7632427 (3p11.1), rs12543318 (8q21.3), rs8001641 (13q31.1), and rs7179658 (15q22.2). We directly sequenced three non‐coding conserved regions 200 kb downstream of SPRY2 in 713 cases, 438 controls, and 485 trios from the US, Mongolia, and the Philippines. We found rs8001641 to be significantly associated with nonsyndromic cleft lip with cleft palate (NSCLP) in Europeans (P‐value = 4 × 10−5, ORtransmission = 1.86 with 95% confidence interval: 1.38–2.52). We also found several novel sequence variants in the conserved regions in Asian and European samples, which may help to localize common variants contributing directly to the risk for NSCLP. This study confirms the prior association between rs8001641 and NSCLP in European populations. © 2015 Wiley Periodicals, Inc.
A Synthetic Erectile Optogenetic Stimulator Enabling Blue‐Light‐Inducible Penile Erection
Authors: Kim Taeuk , Folcher Marc , Baba Marie Doaud‐El , Fussenegger Martin
Published: March 2015

Precise spatiotemporal control of physiological processes by optogenetic devices inspired by synthetic biology may provide novel treatment opportunities for gene‐ and cell‐based therapies. An erectile optogenetic stimulator (EROS), a synthetic designer guanylate cyclase producing a blue‐light‐inducible surge of the second messenger cyclic guanosine monophosphate (cGMP) in mammalian cells, enabled blue‐light‐dependent penile erection associated with occasional ejaculation after illumination of EROS‐transfected corpus cavernosum in male rats. Photostimulated short‐circuiting of complex psychological, neural, vascular, and endocrine factors to stimulate penile erection in the absence of sexual arousal may foster novel advances in the treatment of erectile dysfunction.
Preparation and properties of polyurethane‐modified epoxy cured in different simulated gravity environments
Authors: Li Defeng , Wang Youshan , Liu Yuyan , Xie Zhimin , Wang Lei , Tan Huifeng
Published: March 2015

Great attention has been paid to the composites with interpenetrating polymer networks (IPNs) because of their special performance. However, the influence of sedimentation and convection from different gravity environments on the formation of IPNs and the properties of IPNs blends has received little attention. To understand their influence, environments with different gravity accelerations of 0g, 1g, and 2g were simulated with a superconducting magnet, and tests, including differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), coefficient of thermal expansion (CTE), scanning electron microscopy, and three‐point bending, of the IPNs blends cured in different gravity environments were conducted and analyzed. Fourier transform infrared spectroscopy, DSC, and DMA proved the formation of IPNs during the reaction between the polyurethane prepolymer (PUP) and epoxy resin (E51). The curves of DSC also certified the differences in the curing degree between the different parts along the direction of gravity of a sample. With the increase of mass fraction of PUP, the change trends of the storage modulus presented a linear decrease when samples cured in microgravity environment, but presented a parabolic trend when samples were cured in terrestrial environment. The damping properties of samples cured in simulated microgravity environments are better than those cured in terrestrial environment. With the increase in the simulated acceleration of gravity, the diameter of dispersed phase in a sea‐island structure increased, but their number decreased and the bending stress and CTE of the IPN blends all decreased. These results show the formation of IPNs was affected by different gravity values, and the thermal and mechanical properties of the IPN composites were influenced by the changed IPN components. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42063.
Preparation of grafted cationic polymer/silver chloride modified cellulose fibers and their antibacterial properties
Authors: Chen Xiaoqin , Hu Bojian , Xing Xiaodong , Liu Zuliang , Zuo Yan , Xiang Qian
Published: March 2015

In this article, we present a simple method for synthesizing antibacterial cellulose fibers that were modified with a cationic polymer and immobilized silver chloride (AgCl) particles. Relatively simple techniques of graft polymerization and onsite precipitation were used to fabricate the composites. Scanning electron microscopy images, Fourier transform infrared spectroscopy, X‐ray diffraction, thermogravimetric analysis, and energy‐dispersive X‐ray spectroscopy confirmed the immobilization of the AgCl particles. The observed inhibition zone of the immobilized AgCl particle composites indicated that the biocidal silver ions were released from the composites in aqueous solution. Compared with cationic‐polymer‐grafted cellulose fibers or AgCl alone, the cationic polymer/AgCl composites showed excellent antibacterial activity against Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42092.