bluuebunny/crossref_metadata_2025 huggingface dataset:
Short-term changes in Bruch’s membrane opening-based morphometrics during the first week after trabeculectomy
Authors: Gietzelt Caroline , Lüke Jan-Niklas , Adler Werner , Dietlein Thomas S. , Lappas Alexandra , Prokosch-Willing Verena , Roters Sigrid , Heindl Ludwig M. , Cursiefen Claus , Enders Philip
Published: April 2022

Purpose

To evaluate the dynamics of Bruch’s membrane opening-based morphometrics of the optic nerve head (ONH) using spectral-domain optical coherence tomography (SD-OCT) during the first week after glaucoma surgery by trabeculectomy with mitomycin C.

Methods

Prospective, longitudinal analysis of 25 eyes of 25 patients treated by trabeculectomy. Twenty-four eyes had evaluable postoperative SD-OCT examinations. Bruch’s membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness were analyzed at baseline before surgery, 1 day, 2 to 3 days, and 1 week after surgery. Changes compared to baseline were correlated to intraocular pressure (IOP).

Results

One day after surgery, the mean BMO-MRW changed by + 26.17 µm, p = 0.001 (mean IOP reduction by 17.01 mmHg). This increase persisted on day 2–3 with a mean increase of BMO-MRW of + 25.33 µm, p = 0.001 (mean IOP reduction by 20.46 mmHg) and by week 1 with a mean BMO-MRW increase of + 33.17 µm, p < 0.001 (mean IOP reduction by 22.55 mmHg). The increase in BMO-MRW correlated significantly with the reduction of IOP on day 1 (Spearman’s rho ρ = 0.656, p = 0.003) and d2–3 (Spearman’s rho ρ = 0.479, p = 0.038). There was no statistically significant correlation found between the IOP and the increase in BMO-MRW in week 1.

RNFL thickness showed no significant changes at day 1 as well as days 2–3 (p ≥ 0.078, respectively). It showed a small but significant increase in week 1 by 3.94 µm, p = 0.015.

Conclusions

Structural reversal of disc cupping in BMO-MRW occurs as early as 1 day after trabeculectomy and correlates to the extent of the IOP reduction. During the whole first week after surgery, a strong increase in BMO-MRW can be noted. The changes in BMO-based parameters need to be considered when evaluating patients’ longitudinal follow-up.
Comparison of the decompressive effect of different surgical procedures for dysthyroid optic neuropathy using 3D printed models
Authors: Yo Kinga , Nishimura Kunihiro , Takahashi Yasuhiro , Yokota Hiroki , Hatayama Naoyuki , Hoshino Tetsuro , Naito Munekazu , Ogawa Tetsuya , Fujimoto Yasushi
Published: April 2022

Purpose

To compare the decompressive effect around the optic nerve canal among 3 different decompression procedures (medial, balanced, and inferomedial) using 3D printed models.

Methods

In this experimental study, based on data obtained from 9 patients (18 sides) with dysthyroid optic neuropathy, a preoperative control model and 3 plaster decompression models were created using a 3D printer (total, 72 sides of 36 models). A pressure sensor was placed at the optic foramen, and the orbital space was filled with silicone. The surface of the silicone was pushed down directly, and changes in pressure were recorded at 2-mm increments of pushing.

Results

At 10 mm of pushing, there was significantly lower pressure in the medial (19,782.2 ± 4319.9 Pa, P = 0.001), balanced (19,448.3 ± 3767.4 Pa, P = 0.003), and inferomedial (15,855.8 ± 4000.7 Pa, P < 0.001) decompression models than in the control model (25,217.8 ± 6087.5 Pa). Overall, the statistical results for each 2-mm push were similar among the models up to 10 mm of pushing (P < 0.050). At each push, inferomedial decompression caused the greatest reduction in pressure (P < 0.050), whereas there was no significant difference in pressure between the medial and balanced decompression models (P > 0.050).

Conclusion

All 3 commonly performed decompression procedures significantly reduced retrobulbar pressure. Because inferomedial decompression models obtained the greatest reduction in pressure on the optic nerve canal, inferomedial decompression should be considered the most reliable procedure for rescuing vision in dysthyroid optic neuropathy.
Formation of quasi-static stop band in a new one-dimensional metamaterial
Authors: Ghavanloo Esmaeal , El-Borgi Sami , Fazelzadeh S. Ahmad
Published: April 2022

The main objective of this paper is to propose a new metamaterial capable of generating a quasi-static stop band from zero frequency. The metamaterial is modeled by a lattice system made of mass-in-mass units. The unit cell of the proposed metamaterial contains a resonator connected to bar-spring mechanism embedded in a host mass and also linked to a fixed substrate. The stop band behavior of the new metamaterial is first investigated on basis of a lumped-parameter infinite lattice model. The equations of motion are derived using the Lagrangian approach, and then Bloch’s theorem is used to derive the dispersion relation. Analytical expressions of the stop band edge frequencies are derived in closed-form. The proposed metamaterial is then studied on a finite lattice model to verify the stop band behavior predicted using the infinite lattice model. A closed-form expression of the transmittance is derived using the matrix method. It is shown that there are two frequency regions in the transmittance spectrum of the finite chain in which the amplitude is considerably attenuated which correspond to the stop bands predicted in the dispersion curve of the infinite chain. Finally, a parametric study is performed to investigate the effects of various design parameters of the proposed metamaterial.
Instant and global consistency checking during collaborative engineering
Authors: Tröls Michael Alexander , Marchezan Luciano , Mashkoor Atif , Egyed Alexander
Published: April 2022

Engineering projects involve a variety of artifacts such as requirements, design, or source code. These artifacts, many of which tend to be interdependent, are often manipulated concurrently. To keep artifacts consistent, engineers must continuously consider their work in relation to the work of multiple other engineers. Traditional consistency checking approaches reason efficiently over artifact changes and their consistency implications. However, they do so solely within the boundaries of specific tools and their specific artifacts (e.g., consistency checking between different UML models). This makes it difficult to examine the consistency between different types of artifacts (e.g., consistency checking between UML models and the source code). Global consistency checking can help addressing this problem. However, it usually requires a disruptive and time-consuming merging process for artifacts. This article presents a novel, cloud-based approach to global consistency checking in a multi-developer/-tool engineering environment. It allows for global consistency checking across all artifacts that engineers work on concurrently. Moreover, it reasons over artifact changes immediately after the change happened, while keeping the (memory/CPU) cost of consistency checking minimal. The feasibility and scalability of our approach were demonstrated by a prototype implementation and through an empirical validation.
Inflation Developments in the Euro Area Since the Onset of the Pandemic
Authors: Nickel Christiane , Koester Gerrit , Lis Eliza
Published: April 2022

There is hope that the Russian war on Ukraine could expedite the energy transition in Europe leading to a new and more environmentally sustainable steady state.
On Returning Inflation to Target
Authors: Mann Catherine L. , Brandt Lennart
Published: April 2022

To gauge the breadth of current inflation and prospects for inflation returning to target, we consider disaggregated measures of CPI infl ation to evaluate trends and then consider diff erent scenarios for the realisation for wages and prices.
Would Renationalisation and Co-financing of the Common Agricultural Policy Be Justified?
Authors: Kengyel Ákos
Published: April 2022

During the past decades several attempts have been made to reform the Common Agricultural Policy (CAP). The article analyses the possible new directions of CAP implementation and financing of the CAP. It discusses whether renationalisation and co-financing of the CAP would be a beneficial approach to make the policy more efficient and to help restructuring not just the CAP expenditure but the whole EU budget. The author analyses the changes in light of the new regulatory frameworks to be implemented from 2023.
Modern Monetary Theory: The Right Compass for Decision-Making
Authors: Ehnst Dirk
Published: April 2022

In the November/December 2021 issue of Intereconomics, Françoise Drumetz and Christian Pfister examine Modern Monetary Theory (MMT) and approach it from the policy consequences that would follow. This paper is a reply to Drumetz and Pfister. It restates the core of MMT and offers some suggestions for central banks. Theories are explanations of what we see, and MMT describes money creation and destruction. Hence, MMT cannot be and is not a political manifesto. In contrast to most other theories of money, MMT is falsifiable in its core statements, which are based on a balance sheet approach to macroeconomics. Since many central banks already educate the public about the creation of modern money through bank lending, it would be most welcome if they would do the same for the creation of modern money through government spending. Here, MMT and central bankers can find common ground to move forward and leave the theory of loanable funds and that of the money multiplier behind.
The impact of environmental regulations on the location choice of newly built polluting firms: based on the perspective of new economic geography
Authors: Peng Na , Zhang Xiangjian
Published: April 2022

Based on the unique micro-data of newly built polluting firms for the period of 2009–2018, this paper adopts the conditional logit model to empirically evaluate the impact of environmental regulations on the location choice of polluting firms. Moreover, we extend the theoretical model by considering that the environment regulations not only influence the pollution cost but also the level of technological innovation and labor cost. The empirical results show that polluting firms tend to flow into areas with stringent environmental regulations, which supports the Porter hypothesis, but the effect of environmental regulations have a divergent impact on heavily polluting firms. Heterogeneous analysis indicates that environmental regulations have shown a positive impact on the location choice of private and foreign-funded firms but no significant impact on that of state-owned firms; the impact of environmental regulation is consistent with pollution haven hypothesis for firms in the central region but is in line with Porter hypothesis for firms in other regions. Meanwhile, the probability of air polluting firms entering areas with stricter environmental regulations is higher than that of water-polluting ones. Finally, this paper further empirically tests the conduction mechanism, that is, environmental regulations can affect the location choice of polluting firms by affecting the regional technological innovation capabilities and labor cost.
Assessing the source and delivery processes of organic carbon within a mixed land use catchment using a combined n-alkane and carbon loss modelling approach
Authors: Wiltshire C. , Glendell M. , Waine T. W. , Grabowski R. C. , Meersmans J.
Published: April 2022

Purpose

Understanding fluxes of soil organic carbon (OC) from the terrestrial to aquatic environments is crucial to evaluate their importance within the global carbon cycle. Sediment fingerprinting (SF) is increasingly used to identify land use-specific sources of OC, and, while this approach estimates the relative contribution of different sources to OC load in waterways, the high degree of spatial heterogeneity in many river catchments makes it challenging to precisely align the source apportionment results to the landscape. In this study, we integrate OC SF source apportionment with a carbon loss model (CLM) with the aim of: (i) reducing ambiguity in apportioning OC fluxes when the same land use exists in multiple locations within a catchment; and (ii) identifying factors affecting OC delivery to streams, e.g., buffer zones.

Methods

Two main approaches were used in this study: (i) identification of the sources of freshwater bed sediment OC usingn-alkane biomarkers and a Bayesian-based unmixing model; and (ii) modelling and analysis of spatial data to construct a CLM using a combination of soil OC content modelling, RUSLE soil erosion modelling and a connectivity index. The study was carried out using existing OC andn-alkane biomarker data from a mixed land use UK catchment.

Results

Sediment fingerprinting revealed that woodland was the dominant source of the OC found in the streambed fine sediment, contributing between 81 and 85% at each streambed site. In contrast, CLM predicted that arable land was likely the dominant source of OC, with negligible inputs from woodland. The areas of the greatest OC loss in the CLM were predicted to be from arable land on steeper slopes surrounding the stream channels. Results suggest extensive riparian woodland disconnected upslope eroded soil OC and, concomitantly, provided an input of woodland-derived OC to the streams. It is likely the woodland contribution to streambed OC is derived from litter and leaves rather than soil erosion.

Conclusion

This study demonstrates how location-specific OC sources and delivery processes can be better determined using sediment fingerprinting in combination with CLM, rather than using sediment fingerprinting alone. It highlights that, although wooded riparian buffer strips may reduce the impact of upslope, eroded soil OC on waterways, they could themselves be a source of OC to stream sediments through more direct input (e.g., organic litter or leaf debris). Characterising this direct woodland OC as a separate source within future fingerprinting studies would allow the contributions from any eroded woodland soil OC to be better estimated.
Diversity of biologically active secondary metabolites in the ascomycete order Sordariales
Authors: Charria-Girón Esteban , Surup Frank , Marin-Felix Yasmina
Published: April 2022

Ascomycetes belonging to the order Sordariales are a well-known reservoir of secondary metabolites with potential beneficial applications. Species of the Sordariales are ubiquitous, and they are commonly found in soils and in lignicolous, herbicolous, and coprophilous habitats. Some of their species have been used as model organisms in modern fungal biology or were found to be prolific producers of potentially useful secondary metabolites. However, the majority of sordarialean species are poorly studied. Traditionally, the classification of the Sordariales has been mainly based on morphology of the ascomata, ascospores, and asexual states, characters that have been demonstrated to be homoplastic by modern taxonomic studies based on multi-locus phylogeny. Herein, we summarize for the first time relevant information about the available knowledge on the secondary metabolites and the biological activities exerted by representatives of this fungal order, as well as a current outlook of the potential opportunities that the recent advances in omic tools could bring for the discovery of secondary metabolites in this order.
Enhanced water absorption of tissue paper by cross-linking cellulose with poly(vinyl alcohol)
Authors: Ferreira A. Cláudia S. , Aguado Roberto , Bértolo Raquel , Carta Ana M. M. S. , Murtinho Dina , Valente Artur J. M.
Published: April 2022

Tissue paper was the only paper grade whose consumption increased during 2020 in Europe. In a highly competitive context, this work explores a strategy based on bisacrylamide cross-linkers and poly(vinyl alcohol) (PVA), seeking to enhance the water uptake of pulps for tissue paper and the key properties of the resulting tissue sheets: water absorption capacity, capillarity, softness, porosity, and strength. For that, α-cellulose from cotton and a kraft hardwood pulp, in parallel, were reacted with N,N’-methylenebisacrylamide, both in the absence and in the presence of PVA. The water desorption rate of the modified polymers was monitored. Pulp blends were then mixed with a conventional softwood pulp (30%) to prepare laboratory tissue paper sheets (20 g m–2). For cotton cellulose, cross-linking with PVA more than doubled the water uptake, up to 7.3 g/g. A significant enhancement was also obtained in the case of pulps, up to 9.6 g/g, and in the case of paper, to 11.9 g/g. This improvement was consistent with a drastic increase in porosity, and it was not detrimental to paper strength.

Graphical Abstract
Ambiguities and nonmonotonicities under prosumer power
Authors: Siddiqui Afzal S. , Siddiqui Sauleh A.
Published: April 2022

Prosumers adopt distributed energy resources (DER) to cover part of their own consumption and to sell surplus energy. Although individual prosumers are too dispersed to exert operational market power, they may collectively hold a strategic advantage over conventional generation in selecting DER capacity via aggregators. We devise a bilevel model to examine DER capacity sizing by a collective prosumer as a Stackelberg leader in an electricity industry where conventional generation may exert market power in operations. At the upper level, the prosumer chooses DER capacity in anticipation of lower-level operations by conventional generation and DER output. We demonstrate that exertion of market power in operations by conventional generation and the marginal cost of conventional generation affect DER investment by the prosumer in a nonmonotonic manner. Intuitively, in an industry where conventional generation exerts market power in operations similar to a monopoly (MO), the prosumer invests in more DER capacity than under perfectly competitive operations (PC) to take advantage of a high market-clearing price. However, if the marginal cost of conventional generation is high enough, then this intuitive result is reversed as the prosumer adopts more DER capacity under PC than under MO. This is because the high marginal cost of conventional generation prevents the market-clearing price from decreasing, thereby allowing for higher prosumer revenues. Moreover, competition relieves the chokehold on consumption under MO, which further incentivises the prosumer to expand DER capacity to capture market share. We prove the existence of a critical threshold for the marginal cost of conventional generation that leads to this counterintuitive result. Finally, we propose a countervailing regulatory mechanism that yields welfare-enhancing DER investment even in deregulated electricity industries.
Real-World LEAP Implementation
Authors: Koplin Jennifer J. , Soriano Victoria X. , Peters Rachel L.
Published: April 2022

Purpose of Review

In 2015, findings from the Learning Early About Peanut allergy (LEAP) trial provided the first convincing evidence that peanut allergy may be preventable through early peanut introduction into the infant diet. Here we discuss implementation of the LEAP study findings around the world and emerging evidence of the impacts on infant feeding and food allergy.

Recent Findings

The LEAP findings led to rapid changes in allergy prevention guidelines internationally to recommend early peanut introduction. There is now emerging evidence that this has been followed by a substantial increase in early peanut introduction to infants. Studies investigating the impact of these changes in infant feeding practices on the prevalence of peanut allergy are underway.

Summary

The LEAP trial represented a significant step forwards in food allergy prevention and new research over the past 5 years has provided insights into how best to implement this intervention in the real world.
Determination of Free Amino Acids in Bee Pollen by Liquid Chromatography with Fluorescence Detection
Authors: Ares Ana M. , Martín María T. , Toribio Laura , Bernal José
Published: April 2022

Bee pollen is one of the hive products that is of most interest today due to its multiple beneficial health properties, making it an increasingly popular food supplement. Bee pollen contains many bioactive compounds, such as fatty acids, vitamins, minerals, proteins, and amino acids, among others. In the present study, the free amino acid content was determined in bee pollen by using liquid chromatography coupled to a fluorescence detector. Sample treatment consisted of a solvent extraction of the free amino acids with ultrapure water and a further centrifugation of the extract, which was repeated twice. After that, it was necessary to perform a pre-column derivatization of the amino acids using a combination of two reagents (o-phthalaldehyde and 9-fluorenylmethyl chloroformate) prior to their separation in a Gemini® C18 reverse phase column in gradient elution mode. The analytical performance was evaluated, and several commercial bee pollen samples were analyzed. Significant differences in the free amino acid profile and concentration, which ranged between 19 and 192 mg/g, were observed depending on the botanical origin of the samples.
Delivery of Cancer Survivorship Education to Community Healthcare Professionals
Authors: Pariser Ashley C. , Brita Javin , Harrigan Maura , Capozza Scott , Khairallah Angela , Sanft Tara B.
Published: April 2022

Our pilot study aimed to evaluate the needs of community oncology providers with regard to cancer survivorship education, develop a survivorship curriculum based on the needs assessment, and evaluate the acceptability of the Project ECHO® (Extension for Community Healthcare Outcomes) model for delivery of the survivorship curriculum. A needs assessment was delivered to participants in suburban community cancer practices, and a curriculum was developed based on the results. Participants were enrolled in an ECHO curriculum consisting of 6 sessions from October to December 2019. Participants included registered nurses (RN), registered dietitians (RD), clinical social workers (LCSW), advanced practice providers (APP), radiation oncologists, and medical oncologists (MD). Participants were invited to participate in exit interviews designed to better evaluate the participant experience. Ninety percent of needs assessment participants (n = 37) expressed an interest in cancer survivorship education. Eight participants from 3 community practices in suburban Connecticut enrolled in the ECHO curriculum. Four participants (50%) agreed to participate in exit interviews. Five themes emerged from the exit interviews: interest in survivorship, time, positive experience, empowerment, and community. Our Survivorship ECHO pilot demonstrated the acceptability of the Project ECHO® model for delivering cancer survivorship education to oncology providers. Further research confirming the feasibility of this model in additional oncology provider settings is needed.
Postnatal state transition of cardiomyocyte as a primary step in heart maturation
Authors: Li Zheng , Yao Fang , Yu Peng , Li Dandan , Zhang Mingzhi , Mao Lin , Shen Xiaomeng , Ren Zongna , Wang Li , Zhou Bingying
Published: April 2022

Postnatal heart maturation is the basis of normal cardiac function and provides critical insights into heart repair and regenerative medicine. While static snapshots of the maturing heart have provided much insight into its molecular signatures, few key events during postnatal cardiomyocyte maturation have been uncovered. Here, we report that cardiomyocytes (CMs) experience epigenetic and transcriptional decline of cardiac gene expression immediately after birth, leading to a transition state of CMs at postnatal day 7 (P7) that was essential for CM subtype specification during heart maturation. Large-scale single-cell analysis and genetic lineage tracing confirm the presence of transition state CMs at P7 bridging immature state and mature states. Silencing of key transcription factor JUN in P1-hearts significantly repressed CM transition, resulting in perturbed CM subtype proportions and reduced cardiac function in mature hearts. In addition, transplantation of P7-CMs into infarcted hearts exhibited cardiac repair potential superior to P1-CMs. Collectively, our data uncover CM state transition as a key event in postnatal heart maturation, which not only provides insights into molecular foundations of heart maturation, but also opens an avenue for manipulation of cardiomyocyte fate in disease and regenerative medicine.
A Comparison of Methods for Identifying Informal Carers: Self-Declaration Versus a Time Diary
Authors: Urwin Sean , Lau Yiu-Shing , Grande Gunn , Sutton Matt
Published: April 2022

Objectives

Two main methods for identifying whether an individual is an informal carer are self-declaration and the use of a time diary. We analysed the level and predictors of agreement between these two methods among co-residential informal carers of adult recipients.

Methods

We used the 2014/15 UK Time Use Survey, which is a large-scale household survey for those aged 8 years old and over. It contains an individual questionnaire for self-declaration and a time diary for activity-based identification that records all activity in 10-min slots for two 24-h periods. Our analysis: (i) assesses the degree of overlap across approaches; (ii) explores the differences in characteristics between carers identified via one approach relative to non-carers using a bivariate probit estimator; and (iii) shows what factors are associated with being identified by both approaches using two independent probit estimators.

Results

Out of 6301 individuals, we identified 545 carers (8.6%) by at least one method and only 104 (19.1% of 545 carers) by both methods. We found similar factors predicted caregiving using either method but the magnitudes of the effects of these factors were larger for self-declared carers. Activity-based carers who provided more activities to a dependent adult and spent more time caregiving were more likely to also self-declare.

Conclusions

Our results show low levels of agreement between the two main methods used to identify informal carers. Any assessment of current caregiving research or future means to collect caregiving information should pay particular attention to the identification method as it may only relate to certain carer groups.
A new insight to the analysis of co-authorship in Google Scholar
Authors: Kalhor Ghazal , Asadi Sarijalou Amin , Sharifi Sadr Niloofar , Bahrak Behnam
Published: April 2022

Google Scholar is a search engine for scholarly literature which indexes most academic papers, dissertations, and books that are available online. This paper aims to analyze the characteristics of the manually added co-authorship network (MACN), in which nodes are authors who manually add their collaborators from a list of co-authors suggested by Google scholar based on their joint scholarly work. In addition to this network, we also perform structural analysis on the authors’ fields of interest network (FIN), and their affiliated institute network (AIN). We introduce a new citation metric based on the distribution of authors’ citation count, which captures the position of authors in their research area and can help us in ranking the universities in each scientific field.
Why Resilience in Health Care Systems is More than Coping with Disasters: Implications for Health Care Policy
Authors: Behrens Doris A. , Rauner Marion S. , Sommersguter-Reichmann Margit
Published: April 2022

Health care systems need to be resilient to deal with disasters like the global spread of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) on top of serving the changing needs of a multi-morbid, ageing and often dispersed population. This paper identifies, discusses and augments critical dimensions of resilience retrieved from the academic literature. It pulls together an integrated concept of resilience characterised by organisational capabilities. Our concept does not focus on the micro-level like most resilience literature in health care but addresses the system level with many stakeholders involved. Distinguishing exogenous shocks to the health care system into adverse events and planned innovations provides the basis for our conclusions and insights. It becomes apparent only when dealing with planned interventions that transformative capabilities are indispensable to cope with sudden increases in health care pressures. Due to the current focus on absorptive and adaptive resilience, organisations over-rely on management capabilities that cannot generate a lasting increase in functionality. Therefore, reducing the resilience discussion to bouncing back from adverse events could deceive organisations into cultivating a suboptimal mix of organisational capabilities lacking transformative capabilities, which pave the way for a structural change that aims at a sustainably higher functionality.
Behavioral Insights for Public Policy
Authors: Hall Crystal C. , Jurcevic Ines
Published: April 2022

There has been an increasing effort to integrate behavioral insights into public policy. These insights are often reliant on social psychological research and theory. However, in this relatively young field, policy interventions and behavioral insights are often built on laboratory-based psychological research with effects that can prove to be unstable in the 'real world'. In this Element, the author provides a brief history of how behavioral insights have been applied to complex policy problems. The author describes ways in which behavioral insights have been successful and where they have fallen short. In addition, the author examines unintended negative consequences of nudges and provides a more nuanced examination of their impacts on behavior change. Finally, the author concludes with a set of recommendations for generating more effective practical applications of psychology to the field of public policy.
Trends in antibiotic use before and during the coronavirus disease 2019 (COVID-19) pandemic across an integrated health system with different antimicrobial stewardship program models trends in antibiotic use by ASP model
Authors: Peterson Jennifer M. , White Kristina , Muehling Emily , Ebert Steven C. , Lambi Lisa , Thieman Corey , Peterson Nathan , Deuel Kia , Bushman Amanda M. , Kumar Sudhir , Best Leyla A. , Rosa Rossana
Published: April 2022

Changes in antimicrobial use during the pandemic in relation to long-term trends in utilization among different antimicrobial stewardship program models have not been fully characterized. We analyzed data from an integrated health system using joinpoint regression and found temporal fluctuations in prescribing as well as continuation of existing trends.
Time Savings vs. Access-Based Benefit Assessment of New York’s Second Avenue Subway
Authors: Wang Yadi , Levinson David
Published: April 2022

Under the current practice of benefit-cost analysis, the direct economic benefits produced by a newly built transit facility are assessed based on how it affects travel time and various costs that are associated with transport needs and travel behavior. However, the time-saving-based benefit calculation approach has been questioned and criticized. Given the strong correlation between accessibility and land value, we propose the access-based land value benefit assessment as an alternative, and apply this assessment method to analyzing the Second Avenue Subway project in Manhattan, New York. The primary principle of the access-based method is that the economic value of a transport project’s intangible gains is largely capitalized by nearby properties’ value appreciation, which is directly caused by improved transport accessibility. We find that: (i) the actual travel time saving is lower than originally forecast; (ii) a strong positive correlation between residential property value and job accessibility by transit is observed; (iii) the appreciation in sold property value and rented property value both far exceed total project cost; and (iv) such results support the decision to approve and construct the Second Avenue Subway.
Making Sense of Shame in Response to Racism
Authors: Webster Aness Kim
Published: April 2022

Some people of colour feel shame in response to racist incidents. This phenomenon seems puzzling since, plausibly, they have nothing to feel shame about. This puzzle arises because we assume that targets of racism feel shame about their race. However, I propose that when an individual is racialised as non-White in a racist incident, shame is sometimes prompted, not by a negative self-assessment of her race, but by her inability to choose when her stigmatised race is made salient. I argue that this can make sense ofsomeshame responses to racism. My account also helps to highlight some of the emotional and cognitive costs of racism that have their root in shame as well as a new form of hermeneutical injustice and distinctive communicative harms, contributing to a fuller picture of what is objectionable about racism.
Grid-based calculation of the Lagrangian mean
Authors: Kafiabad Hossein A.
Published: April 2022

Lagrangian averaging has been shown to be more effective than the Eulerian mean in separating waves from slow dynamics in two time scale flows. It also appears in many reduced models that capture the wave feedback on the slow flow. Its calculation, however, requires tracking particles in time, which imposes several difficulties in grid-based numerical simulations or estimation from fixed-point measurements. To circumvent these difficulties, we propose a grid-based iterative method to calculate the Lagrangian mean without tracking particles in time, which also reduces computation, memory footprint and communication between processors in parallelised numerical models. To assess the accuracy of this method several examples are examined and discussed. We also explore an application of this method in the context of shallow-water equations by quantifying the validity of wave-averaged geostrophic balance – a modified form of geostrophic balance accounting for the effect of strong waves on slow dynamics.
Structuring prosecutorial power
Authors: Sepulveda Carla , Wilenmann Javier
Published: April 2022

Prosecutors play a decisive role in contemporary criminal justice. Their decisions greatly influence the output of the system, as well as the behaviour of other criminal justice institutions. By harnessing the power to filter, select and segment the work of criminal justice, prosecutors provide structure to an otherwise unbalanced field. They thus play a key structuring role. However, the prosecutors’ position and the problems that emanate from it have mostly been studied in terms of their power and discretion. We contend that this approach neglects the core problems and challenges connected to the prosecutorial function in contemporary criminal justice and offer a reconstruction of the formal and informal influences that shape the behaviour of prosecutors in providing for structure.
Change in the inflammatory potential of diet over 10 years and subsequent mortality: the Multiethnic Cohort Study
Authors: Park Song-Yi , Lozano Chloe P. , Shvetsov Yurii B. , Boushey Carol J. , Wirth Michael D. , Shivappa Nitin , Hébert James R. , Haiman Christopher A. , Wilkens Lynne R. , Le Marchand Loïc
Published: April 2022

Dietary inflammatory potential assessed by the Dietary Inflammatory Index (DII®) has been associated with health outcomes. However, longitudinal changes in the DII in relation to health outcomes rarely have been studied. This study aimed to examine change in the DII score over 10 years and its association with subsequent mortality in the Multiethnic Cohort. The analysis included 56 263 African American, Japanese American, Latino, Native Hawaiian and White participants who completed baseline (45–75 years) and 10-year follow-up surveys, including a FFQ. Mean energy-adjusted DII (E-DII) decreased over 10 years in men (from −0·85 to −1·61) and women (from −1·80 to −2·47), reflecting changes towards a more anti-inflammatory diet. During an average follow-up of 13·0 years, 16 363 deaths were identified. In multivariable Cox models, compared with anti-inflammatory stable individuals, risk of all-cause mortality was increased with pro-inflammatory change in men (hazard ratio (HR) = 1·13, 95 % CI 1·03, 1·23) and women (HR = 1·22, 95 % CI 1·13, 1·32). Per one-point increase in E-DII score over time, HR was 1·02 (95 % CI 1·00, 1·03) for men and 1·06 (95 % CI 1·04, 1·07) for women (Pfor heterogeneity < 0·001). While no heterogeneity by race and ethnicity was observed for men, the increased risk per one-point increase among women was stronger in non-Whites than in Whites (Pfor heterogeneity = 0·004). Our findings suggest that a change towards a more pro-inflammatory diet is associated with an increased risk of mortality both in men and women, and that the association is stronger in women, especially non-White women, than in men.
Dignity and time perspective: A pilot explorative study in cancer patients
Authors: Andreis Federica , Mirandola Mara , Wedenissow Anna Chiara , Runcan Mariana , Malighetti Clelia , Meriggi Fausto , Zaniboni Alberto
Published: April 2022

Objectives

This study investigated the possible correlation between emotional distress linked to dignity and dysfunctional temporal orientations in the oncological context.

Methods

We conducted an exploratory study between December 2020 and February 2021, referring to a sample of 107 patients in active treatment for solid tumors belonging to the Oncology Department of the Fondazione Poliambulanza (Brescia, Italy). We administered two self-report questionnaires: the Patient Dignity Inventory (PDI-IT) (Italian version, Grassi L, Costantini A, Caruso R, et al. (2017) Dignity and psychosocial-related variables in advanced and nonadvanced cancer patients by using the patient dignity inventory-Italian version. Journal of Pain and Symptom Management 53(2), 279–287), as a measure of perceived level of dignity, and the Italian version of the Zimbardo Time Perspective Inventory scale (ZTPI) (Zimbardo PG and Boyd JN (2009) Il paradosso del tempo. La nuova psicologia del tempo che cambierà la tua vita. Milano: Mondadori), as a measure of the experiential dimensions of time, such as past, present, and future.

Results

From the PDI-IT emerged that our sample reported high levels of physical and psychological distress. Furthermore, we founded higher distress in patients under 55 years (p = 0.04) and lower distress in retired patients (p = 0.01). The ZTPI showed in our patients prevailing orientations to the past-positive (39.3%) and the future (37.4%). We noticed a gender difference: men were mainly oriented to the future while women to the past-positive. Moreover, married subjects reported a prevalent orientation to past-positive and the future. Finally, data analysis found moderate positive correlation between the “Negative Past” dimension of ZTPI and high levels of physical (r = 0.203, p = 0.03) and psychological distress (r = 236, p = 0.01).

Significance of results

In our experience in oncology, dignity and time perspective play a central role as indicators of the quality of care. Our study shows the importance of a treatment path that integrates the constructs of Dignity and Time Perspective to favor a better psychological adaptation.
Drones Discover Hidden Weaknesses of Collapsing Volcanoes
Authors: Wright Clarissa
Published: April 2022

Understanding buried, hidden zones of structural weaknesses within Indonesia’s Merapi volcano can help to substantially advance our ability to predict catastrophic dome failures.
A Coupled Geochemical‐Geodynamic Approach for Predicting Mantle Melting in Space and Time
Authors: Ball P. W. , Duvernay T. , Davies D. R.
Published: April 2022

Geodynamic simulations underpin our understanding of upper‐mantle processes, but their predictions require validation against observational data. Widely used geophysical datasets provide limited constraints on dynamic processes into the geological past, whereas under‐exploited geochemical observations from volcanic lavas at Earth's surface constitute a valuable record of mantle processes back in time. Here, we describe a new peridotite‐melting parameterization, BDD21, that can predict the incompatible‐element concentrations of melts within geodynamic simulations, thereby providing a means to validate these simulations against geochemical datasets. Here, BDD21's functionality is illustrated using the Fluidity computational modeling framework, although it is designed so that it can be integrated with other geodynamic software. To validate our melting parameterization and coupled geochemical‐geodynamic approach, we develop 2‐D single‐phase flow simulations of melting associated with passive upwelling beneath mid‐oceanic ridges and edge‐driven convection adjacent to lithospheric steps. We find that melt volumes and compositions calculated for mid‐oceanic ridges at a range of mantle temperatures and plate spreading rates closely match those observed at present‐day ridges with the same conditions. Our lithospheric step simulations predict spatial and temporal melting trends that are consistent with those recorded at intraplate volcanic provinces in similar geologic settings. Taken together, these results suggest that our coupled geochemical‐geodynamic approach can accurately predict a suite of present‐day geochemical observations. Since our results are sensitive to small changes in upper‐mantle thermal and compositional structure, this novel approach provides a means to improve our understanding of the mantle's thermo‐chemical structure and flow regime into the geological past.
Progression in translational research on spinal cord injury based on microenvironment imbalance
Authors: Fan Baoyou , Wei Zhijian , Feng Shiqing
Published: April 2022

Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many years. Significant progress has been made in research on the pathological mechanism of spinal cord injury. In particular, with the development of gene regulation, cell sequencing, and cell tracing technologies, in-depth explorations of the SCI microenvironment have become more feasible. However, translational studies related to repair of the injured spinal cord have not yielded significant results. This review summarizes the latest research progress on two aspects of SCI pathology: intraneuronal microenvironment imbalance and regenerative microenvironment imbalance. We also review repair strategies for the injured spinal cord based on microenvironment imbalance, including medications, cell transplantation, exosomes, tissue engineering, cell reprogramming, and rehabilitation. The current state of translational research on SCI and future directions are also discussed. The development of a combined, precise, and multitemporal strategy for repairing the injured spinal cord is a potential future direction.
Hsa_circRNA_0088036 acts as a ceRNA to promote bladder cancer progression by sponging miR-140-3p
Authors: Yang Jun , Qi Manlong , Fei Xiang , Wang Xia , Wang Kefeng
Published: April 2022

Circular RNAs (circRNAs) are a class of non-coding RNAs that play vital roles in cancer biology. However, the potential role of hsa_circRNA_0088036 in bladder cancer (BCa) remains unknown. Hsa_circRNA_0088036 was identified by microarray analysis and validated by quantitative real-time polymerase chain reaction. Functional assays were conducted to confirm the effects of hsa_circRNA_0088036 on the growth, migration, invasion, tumorigenesis, and metastasis of BCa cells. The luciferase reporter assay and RNA pull down assay were performed to investigate the interactions between hsa_circRNA_0088036, miR-140-3p, and forkhead box protein Q1 (FOXQ1). Upregulated expression of hsa_circRNA_0088036 in BCa tissues and cell lines was positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsa_circRNA_0088036 inhibited the growth, migration, and invasion of BCa cells both in vivo and in vitro. Mechanistically, hsa_circRNA_0088036 could directly interact with miR-140-3p and act as a miRNA sponge to modulate FOXQ1 expression. Knockdown of hsa_circRNA_0088036 inhibited the proliferation, migration, and metastasis of BCa cells via miR-140-3p/FOXQ1 signaling, suggesting that hsa_circRNA_0088036 is a potential biomarker and therapeutic target for BCa.
Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons
Authors: Li Xiang , Li Haiying , Xu Zhongmou , Ma Cheng , Wang Tianyi , You Wanchun , Yu Zhengquan , Shen Haitao , Chen Gang
Published: April 2022

Neuronal mitochondrial dynamics are disturbed after ischemic stroke. Optic atrophy 1 (OPA1) and its GTPase activity are involved in maintaining mitochondrial cristae and inner membrane fusion. This study aimed to explore the role of OMA1-mediated OPA1 cleavage (S1-OPA1) in neurons exposed to cerebral ischemia and reperfusion. After oxygen-glucose deprivation (OGD) for 60 min, we found that mitochondrial fragmentation occurred successively in the axon and soma of neurons, accompanied by an increase in S1-OPA1. In addition, S1-OPA1 overexpression significantly aggravated mitochondrial damage in neurons exposed to OGD for 60 min and 24 h after OGD/R, characterized by mitochondrial fragmentation, decreased mitochondrial membrane potential, mitochondrial cristae ultrastructural damage, increased superoxide production, decreased ATP production and increased mitochondrial apoptosis, which was inhibited by the lysine 301 to alanine mutation (K301A). Furthermore, we performed neuron-specific overexpression of S1-OPA1 in the cerebral cortex around ischemia of middle cerebral artery occlusion/reperfusion (MCAO/R) mice. The results further demonstrated in vivo that S1-OPA1 exacerbated neuronal mitochondrial ultrastructural destruction and injury induced by cerebral ischemia-reperfusion, while S1-OPA1-K301 overexpression had no effect. In conclusion, ischemia induced neuronal OMA1-mediated cleavage of OPA1 at the S1 site. S1-OPA1 aggravated neuronal mitochondrial fragmentation and damage in a GTPase-dependent manner, and participated in neuronal ischemia-reperfusion injury.