bluuebunny/crossref_metadata_2025 huggingface dataset:
Entropic analysis of optomechanical entanglement for a nanomechanical resonator coupled to an optical cavity field
Authors: Choi Jeong Ryeol
Published: September 2021

We investigate entanglement dynamics for a nanomechanical resonator coupled to
an optical cavity field
through the analysis of the associated entanglement entropies.
The effects of time variation of several parameters,
such as
the optical frequency and the coupling strength, on the evolution of
entanglement entropies are analyzed.
We consider three
kinds
of entanglement entropies as the measures of the entanglement of
subsystems,
which are the linear entropy, the von Neumann entropy, and the Rényi entropy.
The analytic formulae of these entropies are derived in a rigorous way using
wave functions of the system.
In particular, we focus on
time behaviors of entanglement entropies
in the case where the optical frequency is modulated by a small oscillating factor.
We show that the entanglement entropies
emerge and increase as the coupling strength grows from zero.
The entanglement entropies fluctuate depending on the adiabatic variation of the
parameters and such fluctuations are significant especially in the strong coupling regime.
Our research
may deepen the
understanding of
the optomechanical entanglement,
which is crucial in
realizing hybrid quantum-information protocols in quantum computation,
quantum networks, and other domains in quantum science.
Reconceptualizing and modeling sustainable consumption behavior: A synthesis of qualitative evidence from online education industry
Authors: Jiang Songyu , Pu Ruihui
Published: September 2021

In recent years, the concept of sustainable consumption behavior (SCB) is largely introduced and changed continuously to be discussed with industries such as energy sector, agriculture, transportation, sharing economy, and tourism. However, the study of sustainable consumption behavior in the online education industry (SCBOEI) remains a research gap. Thus, this paper aims to identify the significance of sustainable consumption behavior and theoretically conceptualize SCBOEI. This study employs content and text analysis to reconceptualize the major theories that contribute to the research of SCB. The findings in this study show that SCBOEI is contributed of great significance to promote sustainable development. In addition, this study introduces a model of SCBOEI, in which the consumer value theory, social exchange theory, and planned behavior theory are integrated. Additionally, this paper suggests that value, environmental attitude, identity, consumer engagement, and contextual factors (government behavior, market conditions, and environmental education) are highly important to extend the research on SCBOEI. In conclusion, this study strongly recommends that SCB research shall be directed to the online education industry. Furthermore, future studies shall emphasize the empirical effects of psychological factors, activity factors, and contextual factors for SCBOEI to find the correlation.
Enterprise value management based on the stakeholder approach
Authors: Sytnyk Hanna , Vysochyn Iryna , Zhuk Tetiana , Olesenko Inna , Stratiichuk Viktoriia
Published: September 2021

The need to ensure the growth of enterprise value in the context of strengthening intangible factors’ role in its formation and maintaining sustainable development of society requires the introduction of new value-oriented management models, taking into account the interests of a wide range of stakeholders.The paper aimed to develop an approach to enterprise value management based on the stakeholder approach. Based on the presented conceptual vision of the enterprise as an SRPR system (stakeholders-resources-processes-results), a two-level system of SRPR value indicators for the main stakeholder groups has been developed, as well as an integral indicator of sustainable economic value added (EVA), which allows assessing the potential growth of enterprise value through a sustainable network of stakeholders. The possibility of using SRPR indicators in the process of planning activities has been substantiated: a model for maximizing EVA is formulated subject to a number of restrictions reflecting the standards of relationships with stakeholders, its transformation into a matrix of SRPR indicators.The results of approbation of the proposed approach by questioning processing and wholesale trade enterprises in the B2B segment are presented, confirming the compliance of the proposed system of indicators with the interests of stakeholders and implementation at Europroject Ukraine LLC, which proved its practical value.The need for further empirical studies of the dependence of EVA on changes in indicators of satisfaction of stakeholders’ interests is emphasized.
Flexibility of creating and changing employment in the options of the Slovak Labor Code
Authors: Peráček Tomáš
Published: September 2021

Flexibility of the employer’s ability to manage human resources during the several-month “lockdown” due to the COVD-19 pandemic has proven crucial to the survival of a Slovak company. However, this flexibility, unlike other contractual relationships, is strictly regulated by the Slovak Labor Code. Given the scope of the problem, the paper focuses only on issues related to the possibility of creating and changing employment in the Slovak Republic, which must be addressed by the management of all companies. The main purpose of the study is to assess flexibility in creating and changing employment. In processing this managerial issue, analysis, synthesis, deduction, and comparison are used. It was found that the Slovak Labor Code is flexible enough and fulfills its purpose. Despite its flexibility, it also provides an employee with the necessary protection in employment relations and allows him, in agreement with an employer, to grant more rights than he himself guarantees. However, in the current information age, it does not allow for electronic conclusions of legal acts and still prefers the paper form. Another disadvantage is the finding that it does not regulate the institute of a management contract, which objectively causes problems between the employer and the manager, especially in the issue of stability of a managerial position. 
AcknowledgmentThis scientific paper was created within the project VEGA [1/0320/21] “The Role of Universities in Building the Knowledge Economy” and was supported by funds from Comenius University in Bratislava, Faculty of Management.
Features of the modern antihistamines use in the treatment of allergic rhinitis
Authors: Krivopalov A. A. , Rebrova S. A. , Shamkina P. A.
Published: September 2021

Allergic rhinitis remains one of the most relevant problems of modern otorhinolaryngology. The widespread prevalence, late diagnosis, underestimation of the possible risks of disease progression, the development of complications (including asthma) prompts the development and improvement of new treatment options for allergic rhinitis. Allergic rhinitis is a heterogeneous disease that presents with various clinical phenotypes, and therefore the severity of nasal symptoms can vary from mild malaise to severe disease.. Today, pharmacotherapy remains the most frequently used treatment tactic for patients with allergic rhinitis. While prescribing therapy the doctor develops an individual treatment plan based on the principles of personalized medicine, considering: the dominant symptoms, anamnesis data on previous therapy and the effect of treatment, the type of inflammation (Th2-type, mixed inflammation), concomitant diseases (conjunctivitis, asthma, etc.) etc.) and patient preferences. The tissue effects of the histamine mediator lead to the development of symptoms during the course of the disease, which determines the wide-spread use of antihistamines in the treatment of rhinitis. Antihistamines of the second generation are devoid of sedative effects, have a long-lasting effect and a good safety profile. One of the modern II generation antihistamines is bilastine. The research results proved the high antihistaminic activity of bilastine 20 mg in vitro and in vivo, the absence of cardiac and sedative side effects on the central nervous system, the ability to eliminate the nasal and ocular symptoms of disease and improve the quality of life of patients with allergic rhinitis. Thus, bilastine fully complies with current EAACI / WAO ARIA requirements for drugs used to treat AR. The paper presents a clinical case of a patient with chronic persistent allergic rhinitis, household sensitization with a slight uncontrolled course. The oral antihistamine bilastine was added to intranasal glucocorticosteroids, which help to relieve symptoms of the disease, stabilize the condition and prepare the patient for subsequent allergen-specific immunotherapy.
Alternative methods for controlling nasal obstruction in children
Authors: Dvorianchikov V. V. , Drozdova M. V. , Ryazantsev S. V. , Preobrazhenskaya Yu. S. , Pavlova S. S.
Published: September 2021

Currently, rhinitis accompanied by nasal obstruction is one of the most common diseases in children and adolescents. Regardless of the cause of its occurrence - an infectious or non-infectious (allergic) process, each time there is a vascular (vasomotor) reaction. In children of preschool and primary school age, the most common is infectious rhinitis, which develops with viral and bacterial infections. The group of non-allergic rhinitis, which develops more often in adolescents, is united by the term idiopathic (vasomotor) rhinitis.

Purpose of the study. Evaluation of the effectiveness of the use of a complex preparation containing calendula, witch hazel, esculus, menthol and zinc oxide in the treatment of vasomotor rhinitis in children.

Materials and methods. The study included 40 patients of childhood and adolescence, of both sexes (23 girls and 17 boys) aged 6 to 14 years with an established diagnosis of vasomotor (idiopathic) rhinitis, without concomitant pathology, not registered with specialists, without constant admission The study drug was used to lubricate the mucous membrane of the nasal cavity or put turundas with ointment for 3-5 minutes 2-3 times a day. The course of treatment was 7-10 days. The effectiveness of treatment was assessed by the dynamics of clinical data and the severity of the subjective symptoms of the disease.

Results. A comparisons of these scores for re-assessing the status of patients relative to the timing of the study drug use showed a uniform positive trend in terms of the clinical picture and subjective complaints of patients.

Conclusions. The inclusion in the complex therapy of pediatric patients with idiopathic (vasomotor) rhinitis of the drug Fleming’s Ointment, or monotherapy with this agent, contributes to a  rapid and pronounced weakening of  the  clinical manifestations of the disease, allowing you to quickly achieve positive treatment results in the form of relief of nasal obstruction, rhinorrhea, edema of the mucous membrane of the cavity nose, sneezing. There is a positive trend in the state of the mucous membrane itself.
Modern opportunities of pharmacological effect on gut microbiome and motor activity
Authors: Drozdov V. N. , Shikh E. V. , Astapovskiy A. A. , Serebrova S. Yu. , Komissarenko I. A.
Published: September 2021

Currently, lactulose is known to most as a laxative that has a hyperosmotic effect, stimulating intestinal peristalsis. The drug has long established itself as a safe and effective medicine. Lactulose is one of the few drugs that is approved for use in pregnant women and children under 6 months of age with functional constipation. The prebiotic properties of lactulose were discovered in 1957. After research, it was found that it promotes the growth of beneficial bacteria, such as bifidobacteria and lactobacilli. In addition to being used as an effective weak and prebiotic agent, lactulose has been successfully used since 1966 for the treatment of hepatic encephalopathy. The mechanism of action of the drug is that it prevents the absorption of excess ammonia, which is formed in the large intestine, through the hydrolysis of protein and urea by the intestinal microflora. Lactulose, which has a wide range of effects on nitrogen metabolism by the intestinal microflora, affects not only ammonia, but also other bacterial toxins as a result of the studies that have demonstrated the reliable effectiveness of the drug, the world’s leading professional communities have included lactulose in their recommendations as the drug of choice for the treatment of patients with hepatic encephalopathy at any stage of the disease. The article presents current data on the effectiveness and safety of the use of lactulose in various diseases. In addition, attention is paid to such a concept as microbiota. Its functions and influence on the human body are described.
Long-acting insulin analogue in the treatment of type 2 diabetes mellitus: emphasis on proven efficacy and safety
Authors: Biryukova E. V. , Shinkin M. V. , Mikheeva O. M.
Published: September 2021

In time, prescription of insulin therapy (IT) becomes inevitable for many patients with type 2 diabetes mellitus (DM) to achieve and maintain the target hypoglycemic range.

According to the current guidelines, the addition of basal insulin to glucose-lowering therapy in patients with insufficient control of type 2 diabetes, gradual titration of its dose in accordance with a fasting blood glucose level is an effective and safe method for initiating IT. The properties of modern long-acting insulin analogues are considered. Glargine 300 U/ml is a modern analogue of long-acting insulin that is intended to be used once a day. The glargine molecule forms the basis of the drug. Increasing the concentration of glargine per volume unit and formation of a smaller subcutaneous depot led to a change in the pharmacokinetic properties of the drug. Glargine 300 IU/ml provides a more stable, long-term, predictable action with low glycemic variability as compared with glargine 100 IU/ml, which reduces the risk of hypoglycemia. The sugar-reducing efficacy and safety of insulin glargine 300 U/ml as evidenced by the findings of the international clinical phase III EDITION studies are discussed. Insulin glargine 300 U/ml showed a similar decrease in HbA1c levels compared to insulin glargine 100 U/ml with an improved safety profile (lower risk of developing episodes of confirmed or severe hypoglycemia at all times of the day, including the nighttime) and a less pronounced effect on the body weight of patients with type 2 diabetes. The efficacy and safety of the use of glargine 300 U/ml has been confirmed in type 2 diabetes patients with chronic kidney disease and the elderly. In the BRIGHT study, glargine 300 U/ml showed comparable glycemic control when it is being compared.
Choosing an antianginal therapy strategy in patients with stable coronary artery disease in real clinical practice: the advantages of trimetazidine
Authors: Borisova E. V. , Ostroumova O. D. , Pereverzev A. P. , Pavleeva E. E.
Published: September 2021

Cardiovascular diseases (CVD) are the leading cause of death among adults worldwide, including in the Russian Federation. At the same time, the leading position in the structure of causes of death from CVD is occupied by coronary heart disease (CHD) (16% of the total number of deaths in the world per year). The new clinical guidelines of the Ministry of Health of the Russian Federation for the management of patients with stable coronary heart disease in 2020 identify two main goals of conservative therapy – the elimination of symptoms of the disease and the prevention of cardiovascular complications (CVD). In this connection, when choosing antianginal therapy in patients with stable angina, it is necessary to consider the possibility of using combinations of both first-line and second-line drugs in order to really improve the effectiveness of treatment and achieve the goals set. It is advisable and justified to use more widely 2-line drugs, in particular trimetazidine, at any stage of therapy to enhance the antianginal effectiveness of b-blockers, calcium antagonists and prolonged-acting nitrates, especially in patients with hemodynamic features (arterial hypotension, rhythm and conduction disorders), which is demonstrated in the given clinical example. The effective addition of tremetazidine to the arsenal of traditional antianginal drugs is legislated in practice and is reflected in the new clinical recommendations of the Ministry of Health of the Russian Federation in 2020. The accumulated experience of using trimetazidine allows a pathogenetically sound approach to the treatment of stable CHD, restoring the balance between the need and delivery of oxygen to the heart muscle, and the safety profile expands the possibilities of use in patients with comorbid pathology.
Hypothyroidism: find and neutralize
Authors: Verbovoy A. F. , Dolgikh Yu. A. , Katorzhanskaya T. Yu. , Katorzhanskiy V. K.
Published: September 2021

Hypothyroidism is one of the most common diseases of the endocrine system. It is more often recorded in older women. This disease is characterized by nonspecific symptoms and a blurred clinical picture. Patients often have many symptoms from various organs and systems. Because of this, hypothyroidism often remains unrecognized, and patients are not prescribed the necessary therapy on time. Doctors of various specialties should pay attention to the symptoms that may manifest as hypothyroidism. This is especially true for elderly patients. As a screening, the definition of thyroid-stimulating hormone (TSH) is used. First of all, attention should be paid to the pathology of the cardiovascular system, the presence of arterial hypertension, often diastolic and poorly controlled, a decrease in stroke volume and heart rate. Also, in hypothyroidism, lipid metabolism disorders, an earlier onset of atherosclerosis, a connection with metabolic syndrome and type 2 diabetes mellitus were noted. Therefore, it is recommended to diagnose hypothyroidism in patients with these diseases. Screening should also be done in the presence of neurological disorders, depressive and anxiety disorders, gastrointestinal diseases, and hematological disorders (anemias). The determination of TSH is included in the examination plan for infertility, and may also be necessary for other disorders of the reproductive system: menstrual irregularities in women and androgen deficiency in men. Treatment of overt hypothyroidism consists in the appointment of replacement therapy with levothyroxine. If subclinical hypothyroidism is detected, the question of treatment is decided individually and depends on the level of TSH, the patient’s age, and the clinical manifestations of the disease.
Effect of ipragliflozin on metabolic syndrome components and non-alcoholic fatty liver disease
Authors: Petunina N. A. , Telnova M. E. , Kuzina I. A.
Published: September 2021

Sodium-glucose cotransporter-2 inhibitors are the new drugs for the treatment of type 2 diabetes mellitus. Its mechanism of action is to increase the excretion of glucose in the urine due to inhibition of reabsorption in the proximal renal tubules, which leads to a decrease in blood glucose levels. These drugs also have pleiotropic effects including reduce body weight and blood pressure, improve the lipid profile (raising high-density lipoprotein cholesterol and lowering triglyceride levels), and reduce the risk of cardiovascular death and nephroprotection. Ipragliflozin, a new representative of the class of sodium glucose cotransporter-2 inhibitors, registered in Russia, has shown effectiveness in relation to glycemic control, reducing the levels of glycated hemoglobin and fasting plasma glucose both in monotherapy and in combination with other antihyperglycemic drugs. The PRIME-V and ILLUMINATE studies have demonstrated that ipragliflozin helps to reduce insulin resistance, body weight, BMI and waist circumference, total and LDL cholesterol. Positive effects of ipragliflozin on pancreatic β-cell mass and function have been shown in animal studies. Several studies have examined the beneficial effects of ipragliflozin on the course of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus. Significant reductions in ALT and GGT levels and a decrease in the absolute percentage of liver fat have been shown. Animal studies have confirmed the effect of ipragliflozin on the histological characteristics of NASH. The review presents data on the efficacy of ipragliflozin in relation to the components of the metabolic syndrome in patients with type 2 diabetes mellitus, and also discusses the likely mechanisms of a positive effect of the drug on the course of NASH in type 2 diabetes mellitus.
Role of proteoglycans in the treatment of alopecia of various genesis
Authors: Sakaniya L. R. , Melnichenko O. O. , Piruzyan A. L. , Korsunskaya I. M.
Published: September 2021

Hair loss has always been and remains an urgent challenge in the world today. Although this condition is not life-threatening, it still has a strong impact on the patients’ quality of life. Hairlines are affected by multiple factors including age, family history, smoking, nutrition, etc. Alopecia can take many forms, and the specialist’s objective is to determine the correct cause of the disorder of hair growth cycle by taking a medical history from a patient.

The key role in the pathogenesis of androgenetic alopecia is assigned to changes in hormonal status. Telogen effluvium can be triggered by stress, medication, pregnancy, or other medical conditions. For instance, the high number of patients who have had COVID-19 are now faced with hair loss a few months after recovery.

Despite the variety of underlining causes of hair loss, the principle of therapy is the same – the elimination of the trigger and the selection of drugs to normalize the natural hair growth cycle. In this case, the use of drugs containing proteoglycans that are specific proteins involved in the regulation of the hair growth cycle looks promising. Numerous studies demonstrate the efficacy of such proteoglycans as versican, decorin, and syndecan. They activate hair growth and help prolong the anagen phase. This effect of proteoglycans affords to speak about their good therapeutic and even prophylactic properties applied to the problem of hair loss.
Perioperative anemia
Authors: Khovasova N. O. , Naumov A. V. , Tkacheva O. N.
Published: September 2021

Over 10 million operations are performed each year in Russia. A successful surgical treatment demands assessment and mitigation of perioperative risks, one of which is anemia. Patients with low hemoglobin are at greater risk of developing complications and adverse outcomes. These patients more often stay longer at hospitals, have more in-hospital events and readmissions.

Perioperative anemia may be present before surgery, low hemoglobin levels can result from surgery, and can persist after hospital discharge. Preoperative anemia is associated with inferior surgical outcomes and is also an independent risk factor for perioperative complications (acute kidney injury, infectious, thromboembolic, cardiovascular events) and death. Postoperative anemia impairs recovery and increases the risk of reoperations and readmissions.

Absolute and functional iron deficiency is the most common cause of anemia in the perioperative period. The prescription of iron supplements is indicated in the presence of iron deficiency. If the operation is scheduled to be performed in 6 weeks and longer, the prescription of oral iron forms is recommended. If less than 6 weeks remain before surgery, parenteral iron therapy is prescribed. If hemoglobin levels increase insignificantly during such therapy, high-dose iron supplements are indicated. When it comes to emergency surgery and the anemia is not severe, it is recommended to intravenously administer high-dose iron supplements immediately before surgery. In case of severe anemia, blood transfusion is indicated. According to the patient’s blood management concept, blood transfusion should be minimized, including due to the use of high-dose iron supplements, one of which is ferric carboxymaltose.

The choice of treatment for anemia in the postoperative period depends on its severity, the patient’s comorbidities, the type of surgery and the presence of surgical events. In most cases, early intravenous iron therapy is recommended, giving priority to single administration of high-dose iron supplements. Blood transfusion is indicated to patients who have severe anemia, are actively bleeding, and to patients with a severe anemia after the bleeding has been stopped. Iron therapy continues at the outpatient stage of treatment for a long time until the hemoglobin and ferritin levels are normalized, reflecting the replenishment of iron stores in the depot organs.
Antiparkinsonian activity of new N-methyl-D-aspartate receptor ligands in the arecoline hyperkinesis test
Authors: Dergachev V. D. , Yakovleva E. E. , Brusina M. A. , Bychkov E. R. , Piotrovskiy L. B. , Shabanov P. D.
Published: September 2021

Introduction. Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in the population of older patients. Even though long-term combination therapy helps to cope with the main manifestations of PD. It inevitably leads to the appearance of  such side effects as drowsiness, hallucinations, dyskinesia, and many others.  [12]. Therefore, the  search for  effective antiparkinsonian drugs devoid of the above-mentioned adverse reactions remains an urgent task of modern neuropharmacology.

The explored substances are derivatives of imidazole-4,5-dicarboxylic acid. These compounds belong to a fundamentally new class of N-methyl-D-aspartate ligands (NMDA) that are not channel blockers. Their pharmacological effect is realized due to interaction with the NMDA receptor recognition site, which, along with high efficiency, allows us to assume their higher safety, compared to previously existing channel blockers from the NMDA ligand group.

Objective. Studing of  the  antiparkinsonian activity of  new ligands of  the  glutamate NMDA-receptor complex-1,2-substituted imidazole-4,5-dicarboxylic acids on an experimental model of arecoline hyperkinesis.

Materials and methods. Imidazole-dicarboxylic acid derivatives (IEM2258, IEM2248, IEM2247, and IEM1574) were injected into the lateral ventricles of the mouse brain 10 minutes before arecoline in a volume of 5 µl at doses of 0.1-0.5 µmol, then the latent period, intensity, and duration of tremor were recorded. Amantadine was used as a comparison drug.

Results. Preliminary administration of the studied examined substances led to a significant decrease in the intensity and duration of arecoline tremor. The highest inhibitory activity with respect to the intensity and duration of the experimental tremor was demonstrated with the introduction of the compound IEM-2247 (at a dose of 0.1-0.5 mmol, the duration of the latent period of the tremor was 1.7-2.3 times longer than the control one, respectively, the duration of the tremor decreased by 1.5 - 2.5 times).

Conclusions. The  dose-dependent antiparkinsonian activity of  imidazole-dicarboxylic acid derivatives is shown, indicating the prospects for the development of these substances and the further search for effective and safe antiparkinsonian agents among the compounds of this class.
Outpatient management of patients with discogenic lumbosacral radiculopathy
Authors: Prokopovich V. S.
Published: September 2021

Disсоgenic lumbosacral radiculopathy (DLSR) is less common than lumbar musculoskeletal pains, but has a worse forecast and is more often accompanied by a long disabilities. Most patients with DLSR can effectively be treated under polyclinic conditions, but it is not clear how effective conservative methods of DLSR therapy are used in real outpatient practice. This study was carried out in order to analyze the outpatient maintenance of patients with DLSR, which were surgical treatment (lumbar microdiskectomy) due to the ineffectiveness of conservative therapy.

Materials and methods. 90 patients (33 men, 57 women, average age – 59.78 ± 12) years suffered surgical treatment (microdiskectomy) due to the ineffectiveness of conservative DLSR. The duration of the disease to operation ranged from 2 to 14 weeks and was an average of 6 ± 3 weeks.

Results. Patients were not informed about the favorable course of the DLSR, the possibilities of natural (without surgical intervention) of the regression of the disk hernia, as well as expediency to maintain all types of activity, avoid a long bed mode. Only half of the patients were conducted by therapeutic gymnastics. 94.4% of patients received non-steroidal anti-inflammatory funds, 92.2% – muscle relaxant, 79.8% – a complex of vitamins of group B, and epidural blockade with anesthetics and corticosteroids were not used. Relatively widely used ineffective methods of therapy of the DLSR: paravertebral blockade of analgesics (42.2%), intravenous drip administration of actovegin and/or pentoxyfalline (26.7%), magnetotherapy and/or laser and therapy (36.7%).

Conclusion. In an outpatient practice, patients with DLSR do not receive effective conservative treatment, which may be a reason for the early (after 6 weeks) directions for surgical treatment. Polyclinic doctors are poorly informed about the effective conservative methods of DLSR therapy.
Prerequisites for the creation of an atlas of postcovid inflammation as a way of personalized pharmacotherapy, as well as predicting and preventing organ and systemic dysfunctions
Authors: Kukes I. V. , Salmasi J. M. , Ternovoy K. S. , Kazimirskii A. N. , Obodzinskaya T. E. , Lim V. G. , Glagovskiy P. B. , Mamedov I. S. , Poryadin G. V. , Savicheva A. S. , Kukes E. A. , Ptitsyn M. S. , Andreev A. D.
Published: September 2021

SARS-CoV-2 is a novel coronavirus that has been identified as the cause of the 2019 coronavirus infection (COVID-19), which originated at Wuhan city of PRC in late 2019 and widespread worldwide. As the number of patients recovering from COVID-19 continue to grow, it’s very important to understand what health issues they may keep experiencing. COVID-19 is now recognized as an infectious disease that can cause multiple organ diseases of various localization. It is against this background that a new term was introduced: post-acute post-COVID-19 syndrome characterized by several persistent symptoms inherent in the acute phase of the disease, as well as the occurrence of delayed and (or) long-term complications beyond 4 weeks from the onset of the disease. The work reflected in this article revealed a portrait of a patient with post-COVID-19 syndrome, the most common complications of this period, as well as the mechanisms of their development and the resulting metabolic, cellular, tissue disorders leading to the tissue and organ dysfunctions. A comprehensive biochemical and immunological screening was carried out using the example of three clinical cases to identify the most significant disorders in these patients and to correlate with their clinical status over time. In point of fact, such patients were diagnosed with vascular dysfunction factors (development of endothelial dysfunction), metabolic dysfunction factors (metabolic acidosis, mitochondrial dysfunction, carbohydrate metabolism disorder, insulin resistance, altered branched-chain and aromatic amino acid metabolism), neurological disorder factors (neurotoxicity of the resulting metabolites), immunological disorder factors (decreased efficiency of detoxification systems, secondary immunodeficiency, risk of secondary bacterial infection).
EVDE EĞİTİM HİZMETLERİNİN UYGULAMA SÜRECİ İLE İLGİLİ ÖĞRETMEN GÖRÜŞLERİNİN BELİRLENMESİ
Authors: ATBAŞI Zehra , PÜRSÜN Tuğba
Published: September 2021

Bu araştırmanın amacı, öğretmenlerin evde eğitim hizmetlerini uygulama süreci ile ilgili görüşlerinin be-lirlenmesidir. Durum çalışması olarak desenlenen araştırmanın çalışma grubunu on altı öğretmen oluşturmak-tadır. Araştırmanın çalışma grubunun belirlenmesinde kolay ulaşılabilir durum örneklemesi yöntemi ben-imsenmiştir. Araştırmacılar tarafından geliştirilen yarı yapılandırılmış görüşme formu kullanılarak elde edilen veriler betimsel analiz tekniği kullanılarak analiz edilmiştir. Araştırmadan elde edilen bulgulara göre öğretmenler evde eğitim verdikleri öğrencilerin en fazla iletişim ve sosyal beceri sorunları gösterme eğiliminde olduğunu be-lirtmiştir. Öğretmenler ev ortamının eğitim için uygun olmaması nedeniyle fiziksel düzenlemeler yapmaları gerektiğini belirterek ailenin maddi durumu, materyal eksikliği, ders saatini ayarlama ile ilgili de güçlükler yaşadıklarını ifade etmişlerdir. Öğretmenlerin materyalleri kendileri temin ederek, ortam düzenlemesi yaparak, işbirliği sağlayarak, yardım alarak ve zamanı aileye göre ayarlayarak karşılaştıkları güçlükleri çözmeye çalıştıkları sonucuna ulaşılmıştır.
COMPETÊNCIAS E HABILIDADES DEMANDADAS EM UM PROFISSIONAL CONTÁBIL ATUANTE EM ESCRITÓRIO DE CONTABILIDADE E COMO ELAS SE RELACIONAM ÀS DIRETRIZES CURRICULARES NACIONAIS PROPOSTAS PARA O CURSO SUPERIOR
Authors: Souza Fabricio Afonso de , Arruda Pedro Henrique Temer
Published: September 2021

Este estudo relacionou as habilidades e competências demandadas ao Contador e as habilidades e competências propostas pelas Diretrizes Curriculares Nacionais para o curso de graduação em Ciências Contábeis (DCN). Para tanto, analisou-se a aptidão em apresentar tais competências em colaboradores de um escritório de contabilidade da cidade de Manhuaçu/MG, observando níveis de Likert em uma pesquisa de levantamento. Foram construídas análises de aptidão segregando os dados por setor de atuação no escritório, por habilidades alinhadas a trabalhos técnicos e de análise, planejamento e gestão. Foram relacionadas as habilidades e competências propostas pelas DCNs e as competências do Contador, propostas por Cardoso (2006). Os resultados do estudo sugerem que os respondentes detêm competências mais alinhadas a habilidades técnicas, como a realização de escriturações, apurações e atendimento básico, se comparadas à habilidades analíticas e de gestão, como o planejamento, coordenação e execução de ações práticas de longo prazo, além de atendimento aprofundado das demandas dos clientes. Estes resultados sugerem que os respondentes se sentem mais aptos à realização de trabalhos que lhes exigem apresentar as competências mais técnicas propostas pelo curso de Ciências Contábeis, distanciando-os das habilidades que os aproximarão de assumir postos gerenciais, como Analista Contábil e Contador responsável.
UMA ANÁLISE DO PROCESSO DE ADOÇÃO POR CASAIS HOMOAFETIVOS EM FACE DOS PRINCÍPIOS CONSTITUCIONAIS
Authors: Mendes Andréia Almeida , Arakaki Fernanda Franklin Seixas , Antunes Rosana Maria de Morais e Silva , Costa Giovana Lomeu Terra , Guerra Sarah Lopes , Rodrigues Vítor Oliveira Rubio
Published: September 2021

Tendo em vista a possibilidade de adoção por pares homoafetivos, discute-se, no presente artigo, acerca da realização de tal processo, em face dos preceitos constitucionais brasileiros, a fim de analisar, por meio da interpretação dos princípios basilares, dentre os quais se insere especialmente o da dignidade da pessoa humana, da igualdade, da busca da felicidade e da afetividade, a força da decisão da Suprema Corte em meio aos princípios norteadores do ordenamento jurídico. Para tanto, examina-se a decisão do Supremo Tribunal Federal acerca do tema, bem como a amplitude do conceito de família na atualidade, a regularidade da união estável e do casamento entre pares homoafetivos. Além disso, questiona-se a respeito da omissão legislativa sobre o assunto e suas consequências. Importante considerar que a jurisprudência já reconheceu a prevalência do vínculo afetivo em relação ao biológico. Isso porque os interesses dos indivíduos são mais bem resguardados por eles, já que o intuito da adoção é criar laços familiares com a criança adotada. Ademais, a doutrina já defende o conceito da multiparentalidade, que diz respeito à possibilidade de um indivíduo ter duas mães ou dois pais, mediante o argumento da coexistência dos vínculos afetivos e biológicos.  Realiza-se, então, uma pesquisa bibliográfica de abordagem qualitativa e método hermenêutico. Diante disso, verifica-se que não existe diferenciação em relação a adoção realizada por casais homoafetivos e por casais heterossexuais, o que impõe que o direito de família seja abordado como matéria de ordem pública. Destaca-se, ainda, a importância de analisar esse cenário como forma de desenvolvimento social e proteção à criança e ao adolescente.
CAPITALISMO VERDE E JUSTIÇA DISTRIBUTIVA NO DESCARTE DE RESÍDUOS ELETROELETRÔNICOS
Authors: Coêlho Diego Henrique Damasceno , Correa Camila Braga , Ribeiro Flavio , Mendes Andreia Almeida , Altino Filho Humberto Vinício
Published: September 2021

O presente artigo tem por escopo examinar, em ótica interdisciplinar, o capitalismo verde como mecanismo de gestão no descarte de resíduos eletroeletrônicos, perfazendo uma análise crítica quanto às práticas anticapitalistas e não consumistas como métodos redutores da poluição por obsolescência programada, bem como as legislações brasileiras e os esforços de organizações internacionais voltados para a redução de impactos ecológicos poluidores, ligados à produção industrial, o consumo e má gestão do lixo, face a interesses políticos, econômicos e sociais, no intuito de promover uma abordagem contextualizada em sede da metodologia investigativa empregada, que compreende a revisão qualitativa bibliográfica, através de um viés crítico e comparativo, examinando também informações quantitativas nas produções mais recentes, num diálogo entre árvores científicas, tendo como pano de fundo a justiça distributiva na teoria da justiça como equidade, de John Rawls (1997) e revisitada por Ronald Dworkin (2006), como uma equidade social, aplicada à promoção do direito à cidade, proposta por Henry Lefebvre (2001).
PREVALÊNCIA DE CASOS DE TUBERCULOSE NOTIFICADOS NO PARÁ DE 2009 A 2020: revisão integrativa
Authors: Rêgo Angélica Marques , Pereira Euliane Da Cruz , Gaia Romisléia Alves , Santos Ana Cristina Doria Dos
Published: September 2021

A tuberculose é causada pela bactéria Mycobacterium tuberculosis e possui altas taxas de prevalência no Brasil e subnotificação. Esta revisão de literatura teve o objetivo de analisar e discutir sobre a prevalência da tuberculose no Pará. Trata-se de uma revisão integrativa, orientada pelos descritores “tuberculose”, “prevalência”, “epidemiologia” e “Pará” verificados nos Descritores em Ciência da Saúde (DECS) de acordo com cada base de dados. Foram utilizadas as buscas bibliográficas nas bases de dados Scientific Electronic Library (Scielo) e Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS). Foram incluídos artigos com temática sobre a prevalência de tuberculose no estado do Pará, publicados entre 2009 a 2020, e foram excluídos artigos incompatíveis com o tema. Como resultado foi obtido um quantitativo de dez estudos. Após a análise destes trabalhos, foram encontrados estudos, principalmente no Scielo com dados da prevalência em Ananindeua, Belém, Benevides e Santarém, com casos em homens adultos, ensino fundamental e de zona urbana. O coeficiente de prevalência em Ananindeua foi de 58,93/100.000 habitantes. Belém possui taxa de prevalência de tuberculose de 50,7%, valor superior ao preconizado pelo Ministério da Saúde de 30%. Benevides apresentou o coeficiente de prevalência de 105/100.000 habitantes por ano. Já em Santarém verificou-se alta taxa de coinfecção de tuberculose e HIV. O presente estudo reafirma a alta magnitude da tuberculose no Pará. Os resultados mostram que a tuberculose continua sendo um problema de saúde pública. Torna-se necessário elaborar e implementar políticas públicas para controle das altas taxas de tuberculose nessas cidades, bem como intensificar os estudos em outras regiões do estado como o sudeste do Pará, para que possibilite de fato uma verificação real do número de casos dessa doença no estado.
ANÁLISE DOS MECANISMOS IMUNOLÓGICOS MICROGLIAIS DURANTE A RESPOSTA INFLAMATÓRIA CONTRA EXPOSIÇÃO INFECCIOSA POR SARS-COV-2
Authors: Oliveira Mariana De Jesus , Santos Ana Cristina Doria dos
Published: September 2021

Diante de um cenário de pandemia, manifestações neurológicas, apesar de não serem frequentes, têm sido observadas em pacientes acometidos pela COVID-19. Propôs-se, então, uma análise dos mecanismos imunológicos utilizados pela micróglia frente a um processo infeccioso causado pelo vírus SARS-CoV-2 a fim de encontrar pontos divergentes e convergentes entre os estudos sobre este tema. Trata-se de uma revisão integrativa da literatura, os dados foram coletados no período de 14 de junho a 01 de agosto de 2020 e, inicialmente, realizou-se uma busca no DecS server (Descritores em Ciências da Saúde DecS) e foram selecionados os seguintes descritores: Microglia, Citocinas, Coronavirus, suas combinações e variantes em inglês; nenhum descritor foi utilizado sozinho. Foram encontrados 6.725 estudos por meio da leitura do título e do resumo e foi possível excluir 6.718 artigos por serem duplicados nas bases de dados, publicados em espanhol e que fossem artigo de revisão. Desta forma, apenas 7 artigos obedeceram aos critérios de inclusão (responder à questão norteadora da pesquisa, publicados em 2020) e exclusão mencionados acima. Após leitura completa dos artigos anteriormente selecionados, verificou-se uma amostra final de 6 artigos publicados em inglês em quatro países diferentes, classificados em 3 desenhos de estudos distintos. A pesquisa evidenciou uma grande participação da micróglia como intermediadora dos processos inflamatórios decorrentes de processos infecciosos por SARS-CoV-2 e por outros vírus que refletissem seu mecanismo infeccioso no sistema nervoso central (SNC). Constatou-se, também, a atividade microglial presente em pacientes com doenças acentuadas ou desencadeadas pelo SARS-CoV-2, demonstrando a atuação desta célula de defesa como estimuladora da liberação de citocinas pró-inflamatórias. Espera-se que este estudo possa contribuir para o incentivo à pesquisa relacionada a este tema, visando promover um olhar cauteloso sobre as reações imunológicas no SNC presentes em pacientes que manifestam sintomas neurológicos decorrentes do COVID-19.
O SUPREMO TRIBUNAL FEDERAL COMO ÁRBITRO DA FEDERAÇÃO: A FUNÇÃO INTEGRATIVA DA CORTE NOS INCIDENTES PROCESSUAIS DE CONTRACAUTELA NO CONTEXTO DO PLANO MINAS CONSCIENTE.
Authors: Lara Reinaldo Pinto
Published: September 2021

O presente artigo tem como objetivo analisar as recentes decisões proferidas pelo Supremo Tribunal Federal (STF), enquanto árbitro da federação, em incidentes processuais de contracautela oriundos de conflitos federativos entre o Estado de Minas Gerais e diversos Municípios mineiros no contexto do programa estadual de enfrentamento da pandemia de Covid-19, denominado Plano Minas Consciente. Trata-se de trabalho original através do qual se busca analisar a função integrativa da Corte Constitucional na solução de conflitos de repartição de competências constitucionais, notadamente em relação à legitimidade, natureza, duração e limites das medidas restritivas de interação econômico-social previstas em âmbitos estadual e municipais, tendo por vetor hermenêutico a conformação da autonomia municipal e o exercício das competências concorrentes à observância do princípio constitucional da predominância do interesse. O artigo contextualiza o federalismo cooperativo em matéria de saúde pública com a recente alteração da trajetória decisional do STF em conflitos federativos sanitários no cenário da pandemia do Covid-19. Utilizou-se do método dedutivo como diretriz, amparado por pesquisa de natureza bibliográfica para revisão sistemática da matéria, bem como a análise das recentes decisões da Corte Constitucional nos anos de 2020 e 2021. Ao final, pretendeu-se ressaltar que as decisões monocráticas proferidas pela Presidência do STF nos incidentes processuais de suspensão dos efeitos de decisões concessivas de segurança, de liminar, de tutela antecipada e de tutela provisória não contrariaram o entendimento firmado pelo plenário da referida Corte no controle concentrado de constitucionalidade da MC-ADI 6.341 e da ADPF 672, tampouco causaram violação ao pacto federativo ou esvaziamento da autonomia legislativa municipal.
PROLEGÔMENOS SOBRE A TEORIA DO DIREITO QUE DERIVOU DA FILOSOFIA ANALÍTICA
Authors: Reis Wagner Da Silva , Mendes Andreia Almeida , Arakaki Fernanda Franklin Seixas
Published: September 2021

O presente texto apresenta conceitos da filosofia analítica e da filosofia da linguagem, que representaram um giro conceitual no início do século XX. Com bases na filosofia analítica, algumas teorias do direito passaram a ser propostas e constituem-se em importante arcabouço do pensamento jurídico atual debatido nos tribunais do mundo ocidental. O objetivo foi de apresentar um texto preliminar sobre o delineamento desta trajetória da teoria do direito que derivou da filosofia analítica. Apresentam-se conceitos de filosofia analítica e da linguagem, o positivismo jurídico de Herbert Hart, a teoria liberal do direito de Ronald Dworkin e o pensamento positivista de teóricos do direito que derivou do debate entre Herbert Hart e Ronald Dworkin; e, a seguir, a teoria do direito natural de base analítica de John Mitchell Finnis. A metodologia utilizada se valeu do método de abordagem dedutivo e o método de procedimento foi o histórico modificado, incorporando a percepção da autoria.
INSTAGRAM COMO ESTRATÉGIA DE APRENDIZAGEM COLABORATIVA NO ENSINO SUPERIOR
Authors: Rodrigues Pereira Adriana
Published: September 2021

Com o advento de novas tecnologias, torna-se necessário repensar as metodologias tradicionais de ensino. As metodologias ativas de aprendizado têm como intuito promover uma postura ativa dos discentes durante o processo de ensino-aprendizagem. Dessa forma, os alunos são os protagonistas do processo e os docentes atuam como mediadores. Este artigo tem como objetivo apresentar as potencialidades da utilização do Instagram como uma ferramenta de ensino-aprendizagem colaborativa, visando integrar o contexto digital com as metodologias ativas. O estudo descritivo compreende uma atividade aplicada para discentes de engenharia civil de uma instituição privada de ensino superior, localizada em São João del-Rei, MG. No percurso metodológico, foram realizadas quatro etapas: 1) apresentação do trabalho aos discentes; 2) elaboração e publicação das postagens; 3) avaliação das postagens; 4) feedback dos discentes. Os resultados sugerem a efetividade do Instagram como recurso didático para o ensino superior. Além do desenvolvimento das competências, de acordo com os objetivos de aprendizagem propostos para a atividade, a metodologia ativa permitiu que a aprendizagem fosse mais divertida e inserida ao cotidiano dos alunos, promovendo uma aprendizagem mais significativa aos estudantes da cultura digital. Salienta-se, ainda, que nesse tipo de atividade o conhecimento técnico não fica restrito apenas à IES e é democratizado, permitindo que a comunidade externa também tenha acesso à informação técnica.