bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Metode Extreme Gradient Boosting (XGBOOST) pada Klasifikasi Nasabah Kartu Kredit
Authors: Herni Yulianti Sri Elina , Oni Soesanto  , Yuana Sukmawaty
Published: September 2022

Bad credit card is a problem of inability of credit card users to pay credit card bills that can cause losses to both parties concerned. In order to avoid losses caused by bad credit cards, the provider must conduct a careful analysis of prospective or old customers using credit cards. This study aims to classify bad credit card customers using machine learning techniques, namely classification techniques. One of the classification techniques used is the XGBoost method which is useful for regression analysis and classification based on the Gradient Boosting Decision Tree (GBDT), the XGBoost method has several hyperparameters that can be configured to improve the performance of the model. Hyperparameter tuning method used is grid search cross validation which is then validated using 10-Fold Cross Validation. XGBoost hyperparameters configured include n_estimators, max_depth, subsample, gamma, colsample_bylevel, min_child_weight and learning_rate. Based on the results of this study proves that the use of algorithms with hyperparameter tuning can improve the performance of eXtreme Gradient Boosting algorithm in the process of classification of credit card customers with an accuracy of 80.039%, precision of 81.338% and a recall value of 96.854%.

 

Keywords: XGBoost, classification, Accuracy, Precision, Recall
PROJECTS AND PROGRAMS OF AUSTRALIAN GOVERNMENT ON UN AGENDA OF SUSTAINABLE DEVELOPMENT
Authors:   Institute of oriental studies, Russian academy of sciences (MOSCOW), MOSOLOVA Olga V.
Published: September 2022

The most countries of the world established The Sustainable Development Agenda. This plan includes three main directions of sustainable development: interaction of economy, society and environment, and responds to many challenges which lies in front of the mankind up to the present. Australia accepts this Agenda as a guiding principle and recognized the role of sustainable development in the provision of the prosperity in the country. National legislation, measures of regulation and many political decisions aims on the achievement of the ecological, social and economical results indicated in the Agenda of sustainable de-velopment. Together with the government active participation in the Goals of sustainable development realization in Australia assumes business sector with the scientists and organizations of civil society representatives.
AUSTRALIA–CHINA RELATIONS: 1930-1937
Authors:   Pacific National University, Khabarovsk, Russia, KASHINA Evgenia V.
Published: September 2022

The article is devoted to the development of relations between the Australian Union and China in the period from 1930 to 1937. The author analyzes changes in migration and economic policy towards China and explores the views of the Australian public on the Japanese expansion in China since 1931, as well as the position of the official authorities on this issue are revealed. The growth of international contradictions in the 30s of the XX century and the degree of independence in making Australian foreign policy from the former metropolis could affect Australian-Chinese relations.
Pathway to Promote Diversity within Public Transit Workforce
Authors:   University of Florida Transportation Institute (UFTI), Mohebbi Mehri , Raghuram Sumita ,   San Jose State University, Zandiatashbar Ahoura ,   San Jose State University
Published: September 2022

There are many aspects of the transportation industry that can be focused on, but the lack of resiliency is one of the most urgent. Enhancing resiliency and creative problem-solving is essential to the industry’s growth and survival. But it cannot happen without building a more diverse workforce. Women still make up a small fraction of transportation workers, and African American and Hispanic employees are even less represented. These disparities are increasingly pronounced in many senior positions, particularly in STEM fields. Meanwhile, the public transportation industry is experiencing a severe and worsening workforce shortage and many agencies have reported substantial difficulty recruiting, retaining, and developing skilled workers. Considering the transit industry’s existing diversity and inclusion toolkits and guidelines, this project emphasizes lessons from in-depth interviews with leaders from 18 transit agencies across the country. The interviews illuminate the existing challenges and creative solutions around transit workforce diversity and inclusion. From the interviews, we discovered: 1) the critical factors that impact the current level of diversity and career mobility within transit agencies; 2) how diversity efforts help explore resources and provide opportunities for effective and robust employee engagement; and 3) the significance of evaluation systems in creating a more transparent recruitment process that initiates structural shifts, resulting in better recruiting. Moving towards inclusive and equitable workforce environments is a healing process that starts with understanding these gaps. We call this effort Healing the Workforce through Diversification.
Estetika Umah Bolon Simalungun sebagai Identitas Subyektif
Authors: Pratikno Priyo
Published: September 2022

Hidup seseorang dalam komunitasnya semakin sempurna ketika arsitektur memberi kepuasan, pemenuhan akan kemanfaatan dan pencitradiri si subjek. Arsitektur sebagai hasil karya penciptaan memberikan pernaungan jasadi senyampang memenuhi tuntutan jiwa. Maka estetika, tentang keindahan dan sublimasi menjadi bahasan penting dalam pembentukan menemukan identitas subyektifnya. Pada perjalanan waktu identitas membeku menjadi sebuah alat bagi politik identitas dan identitas kedaerahan yang justru mengerdilkan nilai substansinya. Telaah ini didasarkan pada studi lapangan melalui kunjungan yang berinteraksi dengan obyek arsitektur Umah Bolon Simalungun. Analisis temuan di lapangan ditunjang oleh studi kepustakaan khususnya dibaca berdasarkan pandangan Slavoj Zizek tentang konstruksi pembentukan identitas subyektif melalui bahasa. Analisis dilakukan berdasarkan hasil pengamatan lapangan dan diperkuat oleh rekaman foto untuk menemukan dimensi estetik berdasarkan reaksi visual dan pada pemahaman pengamat terhadap obyek tersebut. Hasil pembahasan menunjukkan bahwa estetika arsitektur melampaui tuntutan kerja visual tetapi meluas menjadi bagian dari citra diri yang berasosiasi dengan sistem pertukaran komoditas material. Sistem yang secara ideologis menunjukkan adanya relasi yang tidak sewajarnya sehingga menyamarkan hubungan sosial antar kelompok dalam masyarakat sejauh komoditas merupakan objek yang dihasilkan lewat kerja kreatif.
On a Generalized Framework for Time-Aware Knowledge Graphs
Authors: Krause Franz , Weller Tobias , Paulheim Heiko
Published: September 2022

Knowledge graphs have emerged as an effective tool for managing and standardizing semistructured domain knowledge in a human- and machine-interpretable way. In terms of graph-based domain applications, such as embeddings and graph neural networks, current research is increasingly taking into account the time-related evolution of the information encoded within a graph. Algorithms and models for stationary and static knowledge graphs are extended to make them accessible for time-aware domains, where time-awareness can be interpreted in different ways. In particular, a distinction needs to be made between the validity period and the traceability of facts as objectives of time-related knowledge graph extensions. In this context, terms and definitions such as dynamic and temporal are often used inconsistently or interchangeably in the literature. Therefore, with this paper we aim to provide a short but well-defined overview of time-aware knowledge graph extensions and thus faciliate future research in this field as well.
Assessment of Microbiological Quality, Phytochemicals, Trace Elements and Proximate Analysis of Bio-Clean II Herbal Remedy
Authors: Enitan Seyi Samson
Published: September 2022

The aim of this study was to determine the microbiological quality, phytochemicals, trace elements and proximate analysis of Bio-Clean II. Samples of the herbal remedy were procured from the manufacturer and were analyzed using standard procedure of analysis including sterility test, Spectrophotometry, Atomic Absorption spectroscopy, and gravimetric method. All the batches of Bio-Clean II examined pass sterility test, as no single microbial colony was recovered from them. Physicochemical characterization of the herbal remedy was as follows: pH (6.86), temperature (25oC), relative density (1.08), conductivity (272uS/cm) and total dissolved solid (163mg/L). Phytochemical screening of the herbal remedy revealed the presence of the following bioactive secondary metabolites in varied quantity: resin (+), Flavonoids (+++), Saponins (+), Anthraquinones (+++), Tannin (++), Alkaloids (++) and Cardiac Glycoside (++); except for Steroids which was absent (-). Trace elements analysis revealed the presence of the following in varied quantity: Iron (2.526mg/L), Zinc (0.033mg/L) and Iodine (0.025mg/L), except for Copper and Cobalt which were absent. The results of the proximate analysis were as follows: % Moisture (54.25), % Carbohydrate (11.23), % Crude Protein (12.41), % Crude Fat (9.25), % Crude Fibre (10.65) and % Ash Content (2.21). The outcome of the study shows that all the samples of Bio-Clean II examined were of high microbiological quality and therefore poses no microbial threat to the safety of potential consumers; while the presence of appreciable quantities of some important phytochemical compounds and trace elements in the herbal remedy further underscores its medicinal benefits as earlier reported.

KEY WORDS: _Herbal remedy, Safety, Active Compounds, Mineral Elements, Medicinal values_
Curative Potential of Gbogbonise Epa Ijebu Herbal Remedy in Male Wistar Rats Infected with Salmonella typhi
Authors: Enitan Seyi Samson
Published: September 2022

ABSTRACT

Commercially sold herbal remedies are fast gaining recognition among the Nigerian populace for the treatment of various ailments. The aim of this study was to assess the curative potential of _Gbogbonise Epa Ijebu_ herbal remedy in male Wistar rats infected with _Salmonella typhi_. A total of 60 male Wistar rats weighing 150+50g (mean+SD) were randomly assigned into 10 groups of 6 rats each. Group 1, 2, 3, 7, 8, 9 and 10 were infected with one (1) ml of _Salmonella typhi _suspension with a concentration of 106 CFU/mL in phosphate buffered saline (PBS), except Group 4, 5 and 6 which served as the Zero control, undiluted herbal control and diluted herbal control, respectively. Group 7 and were 8 were treated with 500mg/Kg/bid and 250mg/kg/bid herbal remedy, respectively, while group 9 and 10 were treated with equal volume of Ciprofloxacin and herbal remedy, 500mg/kg/bid and 250mg/kg/bid, respectively, orally twice daily for 7days. Bacterial loads in rectal swab, intestine and gall bladder, as well as the anti-_Salmonella typhi _O and H serum antibodies of the test and control rats were evaluated at Pre-infection, Post-infection and Post-treatment phases using standard microbiological and serological methods. The outcome of this study shows that the administration of the herbal remedy (500mg/Kg/bid) resulted in a significant reduction (_P<0.001_) in the rectal (1.8±04 Log CFU/mL), intestinal (4.25±0.05 Log CFU/Intestine) and gall-bladder (1.85±0.25 Log CFU/Gall-Bladder) bacterial load, as well as the anti-_Salmonella typhi _O (93.3±22.3) and H (93.3±22.3) serum antibodies level of the test groups compared to the infection control (3.8±0.20 Log CFU/mL, 8.3±0.10 Log CFU/Intestine, 4.3±0.06 Log CFU/Gall-Bladder and 173.3±32.1, respectively). The outcome of this study further underscores the curative potential of the herbal remedy as claimed by the manufacturers and vendors.

_KEYWORDS: Gbogbonise Epa Ijebu, Salmonella typhi, Bacterial load, _Anti-Salmonella antibodies, Rats
European Teaching Excellence for Students’ Better Performance: a collection of items in the PISA format for the development of students' mathematical competence
Authors:   Institute of Pedagogy of the National Academy of Educational Sciences of Ukraine
Published: September 2022

The collection of items for the development of students' mathematical competence in the PISA format includes author's competence-oriented tasks in mathematics. In their content, structure and form they are similar to the tasks of the PISA. The collection can be used by primary and high school students, as well as teachers of mathematics to strengthen the applied focus of the mathematics course and implementation of competence approach to teaching mathematics.
Sağlık İnanç Modeli, Turizm Fobisi ve Salgın Hastalıklar
Authors: ŞAHİN Bayram , GÜVEN Selda
Published: September 2022

Covid-19 salgını, toplumsal düzeyde korkuyla bağlantılı fobik davranışları ortaya çıkarabilmekte, bu davranışların görülme sıklığını artırabilmekte, sağlıkla bağlantılı davranış değişiklilerine sebebiyet verebilmektedir. Salgın sona erdikten ya da kontrol altına alındıktan sonra dahi bu dönüşümlerin kalıcı olması beklenmektedir. Turizm endüstrisinin de bu değişimleri yoğun bir şekilde deneyimleyeceği, ortaya çıkan korkunun, paniğin, belirsizliğin ve risk algısının turist davranışını değiştireceği, fobik davranışlara sebebiyet vereceği düşünülmektedir. Nitekim korku, bireylerin kendini tehlikelere karşı koruma altına almak adına savunma mekanizmaları geliştirmesine neden olmaktadır. Sağlığa ilişkin risk algısının yüksek olması ise koruma davranışını ortaya çıkarmaktadır. Bu noktada turistin tatili esnasında kendini güvende hissetmemesi, enfekte olabilme, yakınlarına ya da etrafındaki diğer kişilere hastalığı bulaştırma olasılığı; uluslararası seyahatlerin azalmasına, turistlerin daha kısa süreli seyahatler gerçekleştirmelerine ya da seyahat etmekten tamamen imtina etmelerine sebebiyet verebilir. Bu perspektiften bu çalışmada sağlık inanç modeli, turizm fobisi ve salgın hastalık konuları üzerinde durulmuş, Covid-19 salgının yarattığı korku ve panik ortamının psikolojik etkileri genel hatlarıyla çizilmiştir.
PERANCANGAN SISTEM INFORMASI PENDAFTARAN DAN PEMBAYARAN RAWAT JALAN BERBASIS WEBSITE DI RUMAH SAKIT AMC BANDUNG
Authors: Maesaroh Ana , Trianto Topan
Published: September 2022

In the preparation of this thesis, the authors do research About Registration and Outpatient payment at RS AMC Bandung. According to the researchers, these activities have not been supported by a supportive system so that there are some obstacles such as the occurrence of registration queue, inefficient in serving outpatients. AMC Hospital as one of the public service institutions in the health sector requires the existence of an accurate, reliable, and sufficient information system to improve its services to patients and other related environments.To overcome these problems, the authors designed an information system that can be used to facilitate the data processing of outpatients at the Hospital RS AMC, the method used in designing this system is the method RUP (Rational Unifed Process). RUP (Rational Unifed Process) is a software engineering method developed by collecting various best practices in the software mining industry, where the development tools use UML (Unified Modeling languange).Thus, based on the system that has been created, it can facilitate the registration of patients who can be accessed anywhere, can improve information services for patients who will register and can expand the reach of information.
ON THE ACCURACY OF SOME APPROXIMATIONS FOR THE KOLMOGOROV–WIENER FILTER WEIGHT FUNCTION FOR POWER–LAW STRUCTURE FUNCTION PROCESSES
Authors: GOREV Vyacheslav , GUSEV Alexander , KORNIIENKO Valerii
Published: September 2022

The paper is devoted to the investigation of the accuracy of some polynomial approximations for the Kolmogorov– Wiener filter weight function. The corresponding filter is applied to the prediction of stationary random processes with a power-law structure function. In our previous investigations the Kolmogorov–Wiener filter weight function was obtained on the basis of the truncated polynomial expansion method based on the Chebyshev polynomials of the first kind. It was obtained that some approximations lead to good results; however, some approximations (i.e. the approximations of 9–15 polynomials) fail. The corresponding conclusion was made on the basis of the evaluation of the integrals with the help of the NIntergate function built in the Wolfram Mathematica package. In this paper the corresponding integrals are evaluated on the basis of the rectangle method, the method of trapezoids, and the Simpson method. It is shown that, in contrast to the previous investigations, the approximations of 9–15 polynomials do lead to good results. The aim of the work is to show that, in contrast to the results of previous investigations, the considered polynomial approximations are rather accurate. The methodology consists in the use of the rectangle method, the method of trapezoids, and the Simpson method for the calculation of the left-hand side of the Wiener–Hopf integral equation for the obtained weight function. The scientific novelty consists in showing the validity of some polynomial approximations based on the Chebyshev polynomials of the first kind in the framework of the problem under consideration. The conclusions are as follows. In contrast to the results of previous investigations, it is shown that the approximations of 9–15 Chebyshev polynomials of the first kind for the Kolmogorov–Wiener filter weight function for the prediction of stationary random processes with a power-law structure function are rather accurate.
Pengaturan Suap Di Sektor Swasta Sebagai Suatu Tindak Pidana Korupsi Menurut United Nation Convention Agains Corruption (Uncac) Sebagai Upaya Pemberantasan Korupsi Di Indonesia
Authors: Kurniawan Indra , Marlina Marlina , Harianto Dedi
Published: September 2022

Penelitian ini bertujuan untuk mengetuahui pengaturan hukum mengenai suap di sector swasta, factor-faktor terjadinya suap dan mencegah serta memberantas tindak pidana korupsi. Penelitian ini menggunakan metode hukum normatif dengan mempergunakan pendekatan yuridis normatif (Legal Reseach) untuk mendapatkan data sekunder dilakukan penelitian dengan cara riset dan wawancara, untuk memperoleh data primer melalui bahan-bahan pustaka dan perundang-undangan., berdasarkan indikator adalah sebagai berikut: Pertama, Dalam pembukaan United Nations Convention against Corruption (UNCAC) dinyatakan bahwa negara-negara pada Konvensi tersebut prihatin atas keseriusan masalah dan ancaman yang ditimbulkan oleh korupsi terhadap stabilitas dan keamanan masyarakat yang merusak lembaga-lembaga dan nilai-nilai demokrasi, nilai-nilai etika dan keadilan serta mengacukan pembangunan yang berkelanjutan dan penegakan hukum. Kedua, Penyalahgunaan kewenangan, kesempatan dan sarana khusus yang dimiliki penyelanggaraan negara memiliki andil yang cukup besar dalam melatarbelakangi terjadinya korupsi. Menyalahgunakan kewenangan berarti menyalahgunakan kewajiban yang dibebankan atau yang melekat pada jabatan dan kedudukan seseorang sebagai subjek hukum di tempat dia berada dan bekerja. Menyalahgunakan kesempatan berarti menaylahgunakan waktu yang seharusnya dipergunakan untuk menjalankan kewajiban sesuai dengan jabatan dan kedudukan yang telah dibebankan kepadanya, dan penyalahgunaan sarana merupakan penyalahgunaan alat dan sarana yang melekat padanya yang dipergunakan dalam menjalankan jabatan dan kewajiban sesuai dengan tugas pokok dan fungsi institusi. Ketiga, Penanganan tindak pidana melalui pendekatan peraturan perundang-undangan dikenal dengan upaya penal (represif) yaitu dengan memberikan sanksi bagi siapa saja yang melakukan tindak pidana sehingga memberikan sanksi terhadap tindak pidana suap merupakan reaksi atas perbuatan suap yang telah dilakukan.
City diplomacy and public policy in the era of COVID-19: networked responses from the Greek Capital
Authors: Karvounis Antonios
Published: September 2022

In recent decades, more and more young actors at the international level have been claiming and aspiring to play a significant role in managing public policy issues with global reach. The recent pandemic highlighted the asymmetry of nation-state responses in managing this health threat. At a time that the return-of-the-state scenario sounded familiar, it was misleading as well. Although each national government was focusing on its own people, and each claimed to have been better prepared to fight the crisis than its neighbors, governance gaps were filled by networks of sub-national authorities, whose partnerships provided a wider geographical perspective of policy decisions. In this framework, this article assesses the role of the city diplomacy, focusing on the pandemic initiatives of the city of Athens that, due to its international affiliations, managed to fill the gaps of the measures taken for the most vulnerable groups by the central government during the pandemic of COVID-19. Desk-based research and the use of secondary sources provide the scope for our analysis.
Perilaku Pencegahan dan Faktor Risiko yang Berhubungan dengan Nyeri Punggung Bawah pada Pekerja Pramuniaga Perempuan
Authors: Akbar Muh. Syaiful
Published: September 2022

Nyeri punggung bawah menjadi masalah umum dalam kesehatan global. Beberapa faktor dapat menyebabkan terjadinya nyeri punggung bawah pada tenaga kesehatan, yaitu masa kerja dan lama bekerja dalam sehari. Penelitian ini bertujuan menganalisis perilaku pencegahan dan faktor risiko yang berhubungan dengan kejadian nyeri punggung bawah pada pekerja perempuan di Surakarta dengan penggabungan Health Belief Model (HBM) dan Social Cognitive Teory (SCT). Desain studi menggunakan analitik observational dengan desain cross sectional dilakukan di Surakarta, Jawa Tengah, Indonesia. Penelitian ini mengambil sampel sebanyak 203 pekerja pramuniaga perempuan dengan menggunakan simple random sampling. Pengumpulan data dilakukan dengan kuesioner dan menggunakan uji chi-square. Faktor risiko usia mempengaruhi terjadinya nyeri punggung bawah pada pekerja perempuan (Pv=0,000; OR=5,39), masa kerja (Pv=0,000; OR=5,11) dan lama sikap berdiri (Pv=0.001; OR=0,12). Konsep HBM  yaitu persepsi ancaman turut andil dalam perilaku pencegahan dan faktor risiko terjadinya nyeri punggung bawah (Pv=0,0019; OR=2,47). SCT dalam hal ini observational learning (Pv=0,0001; OR=3,33) dan vicarious learning (Pv=0,000; OR=2,74) berpengaruh terhadap perilaku pencegahan dan faktor risiko nyeri punggung bawah. Perilaku pencegahan dan faktor risiko terjadinya nyeri punggung bawah pada pekerja perempuan di Surakarta signifikan terhadap beberapa beberapa variabel yaitu usia, masa kerja, lama sikap berdiri, persepsi ancaman, observational learning dan vicarious learning.
Tekanan Psikologis COVID-19 terhadap Pelaku Pariwisata di Bali
Authors: Wijaya Made Indra , Pradnyawati Luh Gede
Published: September 2022

Penyakit Coronavirus 2019 (COVID-19) telah menjadi kegawatdaruratan kesehatan masyarakat. Kecepatan COVID-19 menjadi pandemi dan menyebar ke seluruh negara sangat mengkhawatirkan. Salah satu aspek kritis dari jenis pandemi ini adalah pada kesehatan mental komunitas. Survei ini bertujuan mendeskripsikan tekanan psikologis pada pelaku pariwisata di Bali selama pandemi COVID-19. Pengumpulan data dilakukan dari tanggal 8 Juli sampai 5 Agustus 2021. Survei daring menggunakan GoogleForm dengan metoda sampling bola salju digunakan dalam penelitian ini. Instrumen yang digunakan adalah versi modifikasi dari indeks peritraumatic COVID-19 atau COVID-19 peri-traumatic distress index (CPDI) yang terdiri dari 24 pernyataan. Kuesioner dalam survei ini juga menanyakan variabel sosio-demografi dan sosio-ekonomi. Total responden berjumlah 415 dengan 13 responden dikeluarkan dari analisis karena bekerja di luar Bali. Hasil penelitian menunjukkan bahwa sebesar 69% responden tidak mengalami tekanan psikologis, 28% responden mengalami tekanan psikologis ringan hingga sedang dan sisanya 3% mengalami tekanan psikologis berat. Tidak ada variabel sosio-demografi dan sosio-ekonomi yang berasosiasi dengan tingkat tekanan psikologis. Hasil penelitian ini dapat digunakan untuk mengembangkan intervensi psikologis untuk menjaga kesehatan mental selama pandemi.
MANAGEMENT OF UNCERTAINTY IN PROJECTS AND ITS STRATEGIES
Authors: Lima Murilo Campos Rocha , Goussi Sourou Gautier , Costa Borba Marcelo , Marinho Marcelo Luiz Monteiro
Published: September 2022

Uncertainty is the variable factor that affects the project at different stages. The project being carried out in a complex environment with a high load of uncertainty requires an adequate form of management. The project manager is concerned with how to manage the project to achieve success. This study aims to analyze what has been discussed in the last five years, between 2015 and 2020, between the Sciences of Production Engineering, Administration and Computer Science on the management of project uncertainties. To achieve the objective, a systematic review was carried out where the articles were searched in two databases, Scopus and Web of Science. The result explains the importance of managing uncertainty in the project realization environment. The manager must seek to understand the origin of unforeseen events, that is, internal or external. If it is internal, the targeted actions to deal with are more viable, and if it is external, the more tense the actions until the stakeholders are taken into account. Managing project uncertainty requires much more from the team in terms of collaboration and the ability to remain flexible.
Keywords: Risk and uncertainty. Information system. Synthesized management. Collaboration and ability.
 
Resumo: A incerteza é o fator variável que afeta o projeto em diferentes etapas. O projeto sendo executado em um ambiente complexo de alta carga de incerteza exige uma forma de gestão adequada. O gerente de projeto se preocupa em como gerenciá-lo para alcançar o sucesso. Este estudo tem como objetivo analisar o que se discutiu nos últimos cinco anos, entre 2015 e 2020, entre as Ciências da Engenharia da Produção, Administração e Computação sobre a Gestão das incertezas em projetos. Para atingir o objetivo, foi realizada uma revisão sistemática onde os artigos foram pesquisados em duas bases de dados, Scopus e Web of Science. O resultado explica a importância do gerenciamento de incertezas no ambiente de realização do projeto. O gerente deve buscar entender a origem de imprevisto, ou seja, interno ou externo.  Se for interno, as ações direcionadas de lidar são mais viáveis, e se for externa, mais tensas são as ações até os stakeholders são levados em conta. Gerenciar a incerteza de projeto exige muito mais da equipe, no sentido de colaboração e a capacidade de permanecer flexível.
Palavras-Chave: Risco e incerteza. Sistema de informação. Gerenciamento sintetizado. Colaboração e habilidade.
Sistemas de calentamiento y la energía solar: Una revisión sistemática
Authors: Gómez-Naranjo Emily , Bermeo-García Marco , Muyulema-Allaica Juan , Reyes-Soriano Franklin
Published: September 2022

Introducción. La energía solar térmica (EST) encargada del aprovechamiento de la radiación solar para transformarla en calor es una de las formas más alentadora de generación. Objetivo. Efectuar una investigación mediante la revisión sistemática de la literatura (RSL) para responder la interrogante que nos dice ¿Cuáles son los métodos más precisos para la elaboración de un sistema de calentamiento eficiente utilizando energía solar? Metodología. Se trabajó en base a las tres fases de la RSL, que son la planificación, la conducción y la revisión. La base de datos estuvo delimitada a un periodo de 6 años, a partir del 01 de enero de 2016 al 8 de agosto de 2022. Resultados. Los resultados determinaron que las mejores formas de calentamiento es el uso de EST concentrada. Los Colectores Solares Fresnel (CSF) tipo lente generan una eficiencia variable de aproximadamente un 70%. Conclusiones. Se concluyó que los métodos más eficientes para calentamiento de agua o generación de vapor son los colectores solares tipo lente con temperaturas superiores a los 100°C y los colectores de tubos al vacío con temperaturas aproximadas de 120°C, sin embargo, se conoce que las lentes Fresnel varían dependiendo de la cantidad de radiación en el ambiente, por esto, puede llegar a tener temperaturas de hasta 600°C dependiendo de las condiciones climáticas del lugar.
Inflammation and Fibrosis Induced by Joint Remobilization, and Relevance to Progression of Arthrogenic Joint Contracture: A Narrative Review
Authors: Kaneguchi A , Ozawa J
Published: September 2022

Joint immobilization is frequently administered after fractures and ligament injuries and can cause joint contracture as a side effect. The structures responsible for immobilization-induced joint contracture can be roughly divided into muscular and articular. During remobilization, although myogenic contracture recovers spontaneously, arthrogenic contracture is irreversible or deteriorates further. Immediately after remobilization, an inflammatory response is observed, characterized by joint swelling, deposit formation in the joint space, edema, inflammatory cell infiltration, and the upregulation of genes encoding proinflammatory cytokines in the joint capsule. Subsequently, fibrosis in the joint capsule develops, in parallel with progressing arthrogenic contracture. The triggers of remobilization-induced joint inflammation are not fully understood, but two potential mechanisms are proposed: 1) micro-damage induced by mechanical stress in the joint capsule, and 2) nitric oxide (NO) production via NO synthase 2. Some interventions can modulate remobilization-induced inflammatory and subsequent fibrotic reactions. Anti-inflammatory treatments, such as steroidal anti-inflammatory drugs and low-level laser therapy, can attenuate joint capsule fibrosis and the progression of arthrogenic contracture in remobilized joints. Antiproliferative treatment using the cell-proliferation inhibitor mitomycin C can also attenuate joint capsule fibrosis by inhibiting fibroblast proliferation without suppressing inflammation. Conversely, aggressive exercise during the early remobilization phases is counterproductive, because it facilitates inflammatory and then fibrotic reactions in the joint. However, the adverse effects of aggressive exercise on remobilization-induced inflammation and fibrosis are offset by anti-inflammatory treatment. To prevent the progression of arthrogenic contracture during remobilization, therefore, care should be taken to control inflammatory and fibrotic reactions in the joints.
Variants of course of chronic heart failure in patients with cardiovascular pathology after coronavirus infection
Authors: Panina Yu. N. , Vishnevskii V. I.
Published: September 2022

This article analyzes studies that are significant for clinicians aimed at understanding the etiopathogenetic mechanisms that contribute to the development of ischemic, non-ischemic and viral/bacterial-induced heart failure. A systematic search of literature for 2019–2021 was conducted in PubMed, EuropePMC, SCOPUS, the Cochrane Central Database and medRxiv using the search queries ‘Heart Failure’ and ‘COVID-19’; then we focused on publications that contain data on variants of the course of chronic heart failure in patients with cardiovascular pathology after a coronavirus infection and analyzed them with subsequent theoretical modeling. The prevalence of chronic heart failure among the population susceptible to COVID-19 is significant, as is the prevalence of predisposing conditions that expose infected patients to the risk of developing heart failure during illness and in the long-term period after recovery. For this reason, the dissemination of in-depth knowledge about the clinical consequences and prognostic impact of COVID-19 on this vulnerable category is a priority.
ІНСТИТУТ КОНСТИТУЦІЙНОЇ СКАРГИ ЯК ЮРИДИЧНА ГАРАНТІЯ ПРАВ ЛЮДИНИ В УКРАЇНІ
Authors: Магновський І. Й.
Published: September 2022

У статті висвітлено в конституційно-правовому аспекті специфіку діяльності інституту конституційної скарги як юридичної гарантії прав людини в Україні, з урахуванням практики зарубіжного досвіду й особливостей національного конституційного правосуддя. Подано організаційно-правовий характер конституційної скарги, що є формою прямого звернення до органу конституційної юрисдикції, оскільки вона подається особою в інтересах захисту її прав, які порушуються законом у результаті конкретного правозастосування. Акцентовано увагу на такій особливості конституційної скарги, як її структура, – внутрішня будова, котра включає: 1) норми, що регулюють підстави провадження за конституційною скаргою; 2) норми, присвячені предмету оскарження (нормативно-правові акти, що містять ймовірне порушення конституційних прав і свобод та перевірка конституційності яких віднесена до юрисдикції Конституційного Суду України); 3) норми, що визначають особливості правового статусу учасників конституційного оскарження; 4) норми, які закріплюють саму процедуру провадження за конституційною скаргою. Означено підсумкові ознаки конституційної скарги, серед яких: 1) скарга має бути пов’язана з конкретною справою, у якій прийнято остаточне рішення компетентної влади; 2) основою скарги має бути лише порушення прав і свобод особи, які безпосередньо закріплені в тексті конституції держави; 3) скарга має субсидіарний характер, що означає можливість її внесення лише після вичерпання всіх інших доступних засобів правового захисту; 4) розгляд скарги належить до компетенції органу конституційної юстиції, рішення якого має остаточний характер і зобов’язує всі інші органи держави до його виконання.
ДЕНАЦИФІКАЦІЯ РОСІЇ ЯК ПРОБЛЕМА УКРАЇНИ: ДЕЯКІ ПИТАННЯ ДЛЯ ОБГОВОРЕННЯ (ФІЛОСОФСЬКО-ПРАВОВИЙ РАКУРС)
Authors: Литвинов О. М.
Published: September 2022

У статті досліджено питання культурно-історичних засад агресивності етносу із узагальненою назвою «російський» та його політичної організації як московської імперії східно-деспотичного типу, що особливо жорстоко проявилося у відношенні до України. Зроблено спробу пояснити таке становище як природне для ситуації панування людини нового антропологічного типу – «радянська людина», сформоване в ХХ столітті на території колишнього СРСР. Показано, що розділення антропологічного та культурологічного методологічних підходів у дослідженні правознавчих проблем є ефективним способом прояснення багатьох юридичних питань через більшу адекватність формулювання та постановки (відповідних проблем). Зокрема доведено світоглядно-смислову єдність понять «комуністичний», «соціалістичний», «фашистський», «нацистський», що підтверджується й історично через відому фактичність, і логічно (а також у політико-правовому сенсі), через контексти понять «тоталітарний» і «шовіністичний» (та «расистський»), і соціально-психологічно – через поняття «буденний рівень свідомості». Загальнокультурний контекст такої постановки питання забезпечує поняття «культурний код», юридичний – міжнародне право і законодавство України. Порушено питання про логічність усвідомлення ситуації про необхідність денацифікації населення росії, що є наслідком значного історичного, зокрема російсько-радянського світоглядного впливу на Україну. Запропоновано деякі практичні кроки щодо розв’язання цієї проблеми, а саме: реформування освіти та якісно нова підготовка юристів і правоохоронців у ЗВО МВС України.
Going beyond the single case: Comparative Process Tracing as a tool to enable generalizations about causal processes
Authors: Beach Derek , Camacho Gabriela , Siewert Markus
Published: September 2022

In this article, we develop Comparative Process Tracing (PT) as a strategy for validating empirically the scope of cases to which process-level generalizations can be made. While PT methods have discussed internal validity, there has been less attention given to the external validity of processual claims. Comparative PT involves two phases. The intensive phase involves comparing results from two or more PT case studies, both in terms of whether each part of the process was similar and whether the conditions were similar. If a different process is found, then the analysis should focus on identifying the difference between the cases that accounts for different processes. If the causal process operating in the two initial cases is similar, we move to the extensive phase, where the researcher conducts PT ‘light’ studies of ever more diverse cases to explore empirically the bounds of valid processual generalizations.
The Puzzling Place of Disability in Political Science
Authors: Erkulwater Jennifer
Published: September 2022

Disability studies emerged in the 1980s as part of a cluster of politicized identity-based interdisciplinary fields of study in race, ethnicity, and gender that theorized and sought to actualize greater inclusion in academia and society writ large. Political science, however, has been slow to incorporate critical studies of identity and lacks critical sustained engagement with disability. This paper seeks to fill this disciplinary lacunae. I draw from recent theorizing within disability studies and political science to develop a framework for examining how disability structures politics and, in turn, how politics structures disability. I then illustrate the ways in which engagement between disability studies and political science can appropriately center disability within politics and deepen our understanding of political conflict in the United States.
Quantification of Behavioral Deficits in Developing Mice With Dystonic Behaviors
Authors: Van Der Heijden Meike E. , Gill Jason S. , Rey Hipolito Alejandro G. , Salazar Leon Luis E. , Sillitoe Roy V.
Published: September 2022

Converging evidence from structural imaging studies in patients, the function of dystonia-causing genes, and the comorbidity of neuronal and behavioral defects all suggest that pediatric-onset dystonia is a neurodevelopmental disorder. However, to fully appreciate the contribution of altered development to dystonia, a mechanistic understanding of how networks become dysfunctional is required for early-onset dystonia. One current hurdle is that many dystonia animal models are ideally suited for studying adult phenotypes, as the neurodevelopmental features can be subtle or are complicated by broad developmental deficits. Furthermore, most assays that are used to measure dystonia are not suited for developing postnatal mice. Here, we characterize the early-onset dystonia inPtf1aCre;Vglut2fl/flmice, which is caused by the absence of neurotransmission from inferior olive neurons onto cerebellar Purkinje cells. We investigate motor control with two paradigms that examine how altered neural function impacts key neurodevelopmental milestones seen in postnatal pups (postnatal day 7–11). We find thatPtf1aCre;Vglut2fl/flmice have poor performance on the negative geotaxis assay and the surface righting reflex. Interestingly, we also find thatPtf1aCre;Vglut2fl/flmice make fewer ultrasonic calls when socially isolated from their nests. Ultrasonic calls are often impaired in rodent models of autism spectrum disorders, a condition that can be comorbid with dystonia. Together, we show that these assays can serve as useful quantitative tools for investigating how neural dysfunction during development influences neonatal behaviors in a dystonia mouse model. Our data implicate a shared cerebellar circuit mechanism underlying dystonia-related motor signs and social impairments in mice.
Recent advances in nano-drug delivery systems for synergistic antitumor immunotherapy
Authors: Zhao Bonan , Li Xiang , Kong Ying , Wang Wenbo , Wen Tingting , Zhang Yanru , Deng Zhiyong , Chen Yafang , Zheng Xian
Published: September 2022

Immunotherapy has demonstrated great clinical success in the field of oncology in comparison with conventional cancer therapy. However, cancer immunotherapy still encounters major challenges that limit its efficacy against different types of cancers and the patients show minimal immune response to the immunotherapy. To overcome these limitations, combinatorial approaches with other therapeutics have been applied in the clinic. Simultaneously, nano-drug delivery system has played an important role in increasing the antitumor efficacy of various treatments and has been increasingly utilized for synergistic immunotherapy to further enhance the immunogenicity of the tumors. Specifically, they can promote the infiltration of immune cells within the tumors and create an environment that is more sensitive to immunotherapy, particularly in solid tumors, by accelerating tumor accumulation and permeability. Herein, this progress report provides a brief overview of the development of nano-drug delivery systems, classification of combinatory cancer immunotherapy and recent progress in tumor immune synergistic therapy in the application of nano-drug delivery systems.
Epigallocatechin-3-gallate selenium nanoparticles for neuroprotection by scavenging reactive oxygen species and reducing inflammation
Authors: Wang Yiming , Luo Wenqi , Lin Feng , Liu Wanguo , Gu Rui
Published: September 2022

Purpose: Spinal cord injury (SCI) is a severely crippling injury. Scavenging reactive oxygen species (ROS) and suppressing inflammation to ameliorate secondary injury using biomaterials has turned into a promising strategy for SCI recuperation. Herein, epigallocatechin-3-gallate selenium nanoparticles (EGCG-Se NP) that scavenge ROS and attenuate inflammation were used for neuroprotection in SCI.

Methods: EGCG-Se NP were arranged using a simple redox framework. The size, morphology, and chemical structure of the EGCG-Se NP were characterized. The protective effect of EGCG-Se NP for neuroprotection was examined in cell culture and in an SCI rat model.

Results: EGCG-Se NP could promptly scavenge excess ROS and safeguard PC12 cells against H2O2-induced oxidative harm in vitro. After intravenous delivery in SCI rats, EGCG-Se NP significantly improved locomotor capacity and diminished the injury region by safeguarding neurons and myelin sheaths. Component studies showed that the main restorative impact of EGCG-Se NP was due to their ROS-scavenging and anti-inflammatory properties.

Conclusion: This study showed the superior neuroprotective effect of EGCG-Se NP through ROS sequestration and anti-inflammatory capabilities. EGCG-Se NP could be a promising and effective treatment for SCI.
Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review
Authors: Karthic Anandakrishnan , Roy Arpita , Lakkakula Jaya , Alghamdi Saad , Shakoori Afnan , Babalghith Ahmad O. , Emran Talha Bin , Sharma Rohit , Lima Clara Mariana Gonçalves , Kim Bonglee , Park Moon Nyeo , Safi Sher Zaman , de Almeida Ray Silva , Coutinho Henrique Douglas Melo
Published: September 2022

Cancer is still one of the world’s deadliest health concerns. As per latest statistics, lung, breast, liver, prostate, and cervical cancers are reported topmost worldwide. Although chemotherapy is most widely used methodology to treat cancer, poor pharmacokinetic parameters of anticancer drugs render them less effective. Novel nano-drug delivery systems have the caliber to improve the solubility and biocompatibility of various such chemical compounds. In this regard, cyclodextrins (CD), a group of natural nano-oligosaccharide possessing unique physicochemical characteristics has been highly exploited for drug delivery and other pharmaceutical purposes. Their cup-like structure and amphiphilic nature allows better accumulation of drugs, improved solubility, and stability, whereas CDs supramolecular chemical compatibility renders it to be highly receptive to various kinds of functionalization. Therefore combining physical, chemical, and bio-engineering approaches at nanoscale to specifically target the tumor cells can help in maximizing the tumor damage without harming non-malignant cells. Numerous combinations of CD nanocomposites were developed over the years, which employed photodynamic, photothermal therapy, chemotherapy, and hyperthermia methods, particularly targeting cancer cells. In this review, we discuss the vivid roles of cyclodextrin nanocomposites developed for the treatment and theranostics of most important cancers to highlight its clinical significance and potential as a medical tool.
Emerging carbon-based flexible anodes for potassium-ion batteries: Progress and opportunities
Authors: Li Wenbin , Yang Zihao , Zuo Jiaxuan , Wang Jingjing , Li Xifei
Published: September 2022

In recent years, carbon-based flexible anodes for potassium-ion batteries are increasingly investigated owing to the low reduction potential and abundant reserve of K and the simple preparation process of flexible electrodes. In this review, three main problems on pristine carbon-based flexible anodes are summarized: excessive volume change, repeated SEI growth, and low affinity with K+, which thus leads to severe capacity fade, sluggish K+ diffusion dynamics, and limited active sites. In this regard, the recent progress on the various modification strategies is introduced in detail, which are categorized as heteroatom-doping, coupling with metal and chalcogenide nanoparticles, and coupling with other carbonaceous materials. It is found that the doping of heteroatoms can bring the five enhancement effects of increasing active sites, improving electrical conductivity, expediting K+ diffusion, strengthening structural stability, and enlarging interlayer spacing. The coupling of metal and chalcogenide nanoparticles can largely offset the weakness of the scarcity of K+ storage sites and the poor wettability of pristine carbon-based flexible electrodes. The alloy nanoparticles consisting of the electrochemically active and inactive metals can concurrently gain a stable structure and high capacity in comparison to mono-metal nanoparticles. The coupling of the carbonaceous materials with different characteristics can coordinate the advantages of the nanostructure from graphite carbon, the defects and vacancies from amorphous carbon, and the independent structure from support carbon. Finally, the emerging challenges and opportunities for the development of carbon-based flexible anodes are presented.