bluuebunny/crossref_metadata_2025 huggingface dataset:
Capas de livros ilustradas: projeções e visualidades
Authors: Acioli Falcão de Alencar Maria Luísa , D'Alessio Ferrara Lucrécia
Published: December 2019

Colocando a ilustração como uma manifestação artística visual e, em alguns casos, tátil, estuda-se o contexto da estrutura de capa de livro e sua visualidade para exercer apelos ao desejo e curiosidade de leitores, levando-os ao manuseio e à compra do objeto livro. Através da análise da materialidade gráfica e estrutural da produção da capa e suas ilustrações, busca-se entender o papel que exercem sobre o público, enquanto leitores projetados. A partir de seleção de exemplares de capas pertencentes ao mercado editorial independente, procuramos entender a visualidade da capa como elemento persuasivo que fundamenta a ação daquele mercado.
(Eco)Narrativa de uma caminhada na floresta australiana
Authors: Iared Valéria Ghisloti
Published: December 2019

Atualmente, alguns estudiosos do campo da educação ambiental vêm se debruçando sobre o despertar das apreensões estéticas e afetividades sobre a natureza. O manuscrito apresenta uma vivência na natureza por meio de uma (eco)narrativa e discute as interações corporais e multissensoriais entre humanos ~ não humanos durante essa experiência. A partir disso, outros aspectos que vêm sendo pontuados em pensamentos filosóficos emergentes (como novo materialismo, teoria não representacional, ecofenomelogia) são colocadas em diálogo com o objetivo de contribuir com a tríade ontologia ~ epistemologia ~ metodologia na pesquisa. Particularmente, o artigo busca contribuir com investigações que têm por intuito legitimar as afetividades, emoções e não humanos em uma perspectiva menos antropocêntrica.
Alterações Climáticas, incêndios florestais (2017) e as ideias reveladas por alunos do 1.º e 2.ºanos do 1.º Ciclo do Ensino Básico da região de Pombal
Authors: Sousa Cátia Rodrigues , Oliveira Mário Acácio
Published: December 2019

Resumo: Este artigo revela como as ideias de um grupo de 20 alunos, com 6 e 7 anos, residentes na região de Pombal (litoral centro de Portugal), relativamente a incêndios florestais, se sobrepõem às ideias anteriormente trabalhadas, em contexto formal, sobre alterações climáticas. Este facto resulta, muito provavelmente, das experiências (traumáticas) vividas aquando dos incêndios florestais ocorridos na região, em 2017, bem como pela contínua exposição dos alunos à abordagem deste tema por parte dos meios de comunicação social e das conversas informais, na comunidade.

Metodologicamente o trabalho assentou na análise ao conteúdo das representações pictóricas e respostas a um inquérito efetuado pelos alunos relativamente a alterações climáticas - numa primeira fase - e a fogos florestais - numa segunda fase, decorrente dos resultados anteriormente alcançados.

Palavras-chave: Educação Ambiental, Fogos florestais, Ideias prévias
“NOTÓRIA ESPECIALIZAÇÃO” COMO REQUISITO PARA A INEXIGIBILIDADE DE LICITAÇÃO PARA A CONTRATAÇÃO DIRETA PELO PODER PÚBLICO
Authors: Albuquerque Isabel Helena Almeida de
Published: December 2019

O presente artigo científico será focado nas hipóteses de contratação direta por meio da Administração Pública. Questiona-se a legalidade desta contratação e se ela está inserida dentro dos princípios que regem a Administração Pública e o processo licitatório, este responsável pela contratação, alienação de bens, obras e serviços do meio público. A hipótese do trabalho baseia-se na relação que o princípio da obrigatoriedade e as exceções de hipótese de licitação, qual a forma que a lei abrange tais exceções. O artigo será dividido em três capítulos, que abordam a administração pública e seus aspectos gerais, bem como a Lei de Licitações, Lei n. 8.666/93; a dispensa e inexigibilidade da licitação, o princípio da obrigatoriedade e as hipóteses de contratação direta. Por fim, a notória especialização como requisito para a contratação direta, segundo art. 25 da Lei de Licitações. O método de abordagem da pesquisa será o dialético, realizado de maneira comparativa e jurídica por meio de consulta ao acervo de biblioteca e pessoais, bem como sites especializados na Internet.
ASPECTOS SOCIAIS E LEGAIS DO DIREITO REAL DE LAJE
Authors: Correa Ana Paula , Jesus Ruth Estevão de
Published: December 2019

A presente pesquisa versa sobre o direito real de laje recentemente instituído no ordenamento jurídico brasileiro como política pública à regularização fundiária. Nesse sentido inicialmente faz-se uma análise sobre os direitos fundamentais do homem, num estudo constitucional da matéria, focado precipuamente ao direito fundamental de moradia. Posteriormente trata dos direitos reais trazidos pela lei no art. 1225 do Código Civil. Dá-se destaque à propriedade e a outros direitos reais que tenham caráter similar ao direito real de laje. Finalmente, ao final faz-se uma abordagem específica sobre o direito real de laje, destacando-se desde já a dificuldade em tratar do tema dada a escassez de bibliografia a seu respeito. Quanto às técnicas empregadas para a produção deste artigo cientifico, destaca-se a utilização da técnica do referente bibliográfico por meio da pesquisa doutrinária e jurisprudencial. Ao final constata-se que o direito real de laje é um direito real de sobrelevação no qual o proprietário do imóvel cede a superfície da sua laje para outrem dando este a destinação de moradia para si e ou sua família.
PENHORA DE VALORES: A APLICABILIDADE DO SISTEMA PERANTE O PRINCÍPIO CONSTITUCIONAL DA DIGNIDADE DA PESSOA HUMANA
Authors: Buttner Gabriela Zucatti
Published: December 2019

O presente artigo possui como objetivo a análise da aplicação do sistema Bacen Jud a fim de efetivar a restrição de valores, admitida pelo Código de Processo Civil e a Constituição da República Federativa do Brasil, em confronto com a observância do princípio constitucional da dignidade humana. Ele visa explorar o avanço das tecnologias onde se possibilitou que houvesse maior celeridade na efetivação de restrição de valores, sendo esta a primeira opção de garantia processual prevista no art. 835 do Código de Processo Civil. Por outro lado, embora o uso do sistema Bacen Jud, feito através de comunicação instantânea aos bancos e cooperativas, seja importante, vem à tona a questão da ponderação e da moderação de seu uso, uma vez que o uso indiscriminado do sistema pode gerar interferência na esfera íntima do sujeito no que tange à dignidade dos direitos humanos e fundamentais. Analisa-se, ainda, o art. 833 do Código de Processo Civil, que apresenta o rol de impenhorabilidades no caso de valores a fim de garantir uma execução menos onerosa ao executado na solução da lide. Assim, pretende-se demonstrar que a tecnologia é nossa aliada, mas é fundamental que sejam resguardados os direitos e garantias individuais e coletivas previstas na Constituição e em nosso ordenamento brasileiro.
OS REFLEXOS DA OPERAÇÃO MÃOS LIMPAS E DO CASO TORTORA NA COLABORAÇÃO PREMIADA BRASILEIRA
Authors: Gubert Maria Victoria Jaeger
Published: December 2019

O que se pretende com o presente artigo é a análise dos ordenamentos jurídicos brasileiro e italiano, os quais, embora geograficamente distantes, são muito semelhantes entre si, em especial duas das maiores operações contra a corrupção já desenvolvidas no mundo: a Operação Mãos Limpas, ocorrida na Itália nos anos 90, e a presente Operação Lava Jato no Brasil. Uma breve análise do que ocorreu no país europeu se faz de extrema importância para tentar prever o caminho pelo qual o Brasil está trilhando, buscando impedir que os mesmos erros se repitam. Por fim, examinar como se desenvolveu o Caso Tortora, em que delações falsas e um precário conjunto probatório foram usados para condenar um homem inocente como mafioso, também se mostra de essencial importância, a fim de demonstrar a realidade obscura da colaboração premiada, realidade esta que ninguém parece querer admitir que existe.
Apontamentos sobre a pedologia de Vigotski: alguns conceitos importantes em seu contexto histórico
Authors: Aquino Pabliny Marques de , Toassa Gisele
Published: December 2019

Vigotski, na busca de compreender cientificamente a formação dos processos psicológicos tipicamente humanos, dialogou com a pedologia, ciência multidisciplinar que tinha como foco de estudo a criança.  Considerando o comentário aos textos pedológicos do autor, este artigo tem por objetivo central compreender a mencionada ciência na perspectiva de Vigotski, em alguns de seus conceitos basilares. Exploramos, ainda, elementos da história da pedologia, além do Decreto de proibição à pedologia, que descrevemos brevemente. Trazemos resultados de pesquisas bibliográficas de textos de Vigotski traduzidos para o espanhol e para o português, tendo como corpus as obras presentes no Tomo IV, a publicação recente das “Sete aulas sobre pedologia”. O texto descreve a pedologia e a forma como aborda o desenvolvimento, envolvendo a relação com os conceitos de periodização, crise, meio, consciência, personalidade, neoformação e vivências.
A dimensão revolucionária do desenvolvimento e o papel da imaginação
Authors: Souza Vera Lucia Trevisan de , Arinelli Guilherme Siqueira
Published: December 2019

Este artigo, de natureza teórico-reflexiva, tem por objetivo problematizar o tema do desenvolvimento na Psicologia Histórico-Cultural, assumindo-o como revolucionário. A partir de estudos e reflexões apresentam-se compreensões que colocam a imaginação no centro do processo revolucionário empreendido pelo sujeito ao longo de sua vida. Ao final, defende-se, a partir de estudos promovidos com estudantes e profissionais de instituições educativas, a proposição da pesquisa-intervenção como método de investigação e ação que põe o fenômeno do desenvolvimento em movimento e possibilita apreendê-lo.
A emoção e o ensino-aprendizagem em uma perspectiva histórico-cultural: uma pesquisa na educação infantil bilíngue
Authors: Gazzotti Daniele , Souza Marilene Proença Rebello de
Published: December 2019

O presente estudo investiga o desenvolvimento infantil e sua relação com as experiências emocionais vivenciadas em ambiente escolar, tendo por objetivo geral compreender criticamente o vínculo afetivo estabelecido entre educador e educando em contexto escolar sob a perspectiva histórico-cultural. Participam da pesquisa uma educadora e sete crianças de cinco anos de idade de escola de educação infantil bilíngue que realizam uma atividade colaborativa. A condução do processo de aprendizagem considerou o brincar e a agência como elementos mediadores e constitutivos tanto da situação escolar como dos sujeitos envolvidos na atividade, impulsionando o desenvolvimento em todas suas potencialidades: social, cognitiva, afetiva e motora.
Factores clave de éxito. Empresas de confección en Boyacá
Authors: Segura Vargas Ángela M. , Torres Zamudio Marleny
Published: December 2019

El estudio se desarrolló con el objetivo de identificar factores clave de éxito (FCE) en las empresas de Boyacá, Cundinamarca, dedicadas a la confección de ropa de trabajo, estableciendo elementos diferenciales y determinantes en su productividad. Se consultó a expertos en el tema como gerentes de algunas empresas y docentes de programas académicos de diseño industrial y diseño de modas de las universidades de la región, lo anterior utilizando el método Delphi; los resultados muestran que los FCE apuntan hacia el uso de tecnologías para el diseño, patronaje, corte, escalado y tendido de las prendas, calidad de los productos, producción de acuerdo con las necesidades de los clientes y con altas especificaciones técnicas. Las empresas de confección aumentarán su competitividad al automatizar sus procesos productivos, en especial los de diseño y confección, permitiendo agregar valor a la cadena mientras se disminuyen costos y se aporta calidad a los productos.
Vertimientos en la industria de la construcción en Colombia
Authors: García Ubaque Cesar Augusto , Lamprea Molina Laura Constanza
Published: December 2019

En este artículo se aborda la problemática de los vertimientos de aguas residuales generados por la industria de la construcción en Colombia. Se presenta una breve síntesis de la normativa aplicable, estimación de consumos, tecnologías disponibles, tratamientos y uso de subproductos, impacto en la huella ecológica y buenas prácticas. El propósito es recomendar a este sector que genere conocimiento propio sobre su gestión a nivel de producción y tratamiento de aguas en sus procesos, que le permita retroalimentar a partes interesadas como: comunidad y gobierno, y responder a sus demandas de manera más eficiente.
Ingeniería ontológica aplicada a la gestión de interesados de un proyecto
Authors: Cárdenas Quintero Beitmantt Geovanni , Díaz Piraquive Flor Nancy , Fonseca Ruiz Hilma Ximena
Published: December 2019

La gestión de proyectos (vista desde los diferentes estándares y entidades que promueven las buenas prácticas en esta disciplina) refleja que un factor determinante en el éxito o fracaso en la ejecución de proyectos radica en el talento humano que interviene durante el ciclo de vida de este, ya que de acuerdo con su rol y momento de intervención, puede impactar positiva o negativamente el proyecto. Dicha problemática resalta la importancia de contar con un instrumento que permita la identificación, clasificación y seguimiento efectivo de los interesados del proyecto, de tal manera que la toma decisiones frente a este recurso permita hacer una gestión preventiva antes que correctiva, mitigando así el riesgo que pueda generar la desinformación o mala comunicación entre los mismos. Por lo anterior, el objetivo de este artículo, es modelar una ontología que sirva como instrumento de gestión de interesados con elementos semánticos y conceptuales dentro del dominio de la gestión de proyectos, construido a partir de las técnicas de la ingeniería ontológica, la cual permite resolver preguntas puntuales respecto a información concerniente a este recurso de manera ágil, precisa y efectiva, facilitando así su gestión en las fases que componen el ciclo de vida del proyecto. Esta investigación contribuirá con la integración de la ingeniería ontológica y la gestión de proyectos, posibilitando la construcción de una estructura de información de los interesados con componentes semánticos que la habilitan para ser insumo de un modelo de gestión de conocimiento más complejo.
Tecnologías de la Información y la Comunicación y los Objetos Virtuales de Aprendizaje: un apoyo a la presencialidad
Authors: Valero Vargas Rafael Ernesto , Palacios Rozo Jairo Jamith , González Silva Ronald
Published: December 2019

Este documento presenta una reflexión sobre el uso de las Tecnologías de la Información y la Comunicación (TIC) y los Objetos Virtuales de Aprendizaje (OVA) como elementos tecnológicos de apoyo a la presencialidad de espacios académicos prácticos y teórico-prácticos. Para lo anterior, en primer lugar, se hace el estudio de las ventajas de incorporar los OVA en los ejercicios regulares de renovación curricular de las universidades con fines de acreditación. En segundo lugar, se realiza una breve discusión de los aprendizajes más significativos en el uso de las TIC y los OVA en las Instituciones Educativas Superiores (IES). Finalmente se lleva a cabo una examinación sobre el uso de las TIC y los OVA como un apoyo a la presencialidad de espacios académicos teórico-prácticos, donde se destaca que ni las TIC ni los OVA remplazan la labor de un docente que orienta dichos espacios y que las IES deben fortalecer las capacidades de sus docentes y administrativos para ser competitivos en el contexto de la educación superior actual.
Leitmotive und Storylines der Energiewende
Authors: Schmidt-Scheele Ricarda , Bauknecht Dierk , Poganietz Witold-Roger , Seebach Dominik , Timpe Christof , Weimer-Jehle Wolfgang , Weiss Annika
Published: December 2019

Transformationspfade zu einem nachhaltigen Energiesystem beruhen meist auf modellbasierten Szenarien. In den Szenarien müssen gesellschaftliche Prozesse und deren Interaktion mit technologischen, ökonomischen und ökologischen Aspekten betrachtet werden. Dies setzt u.a. eine Integration zentraler Stakeholder-Positionen in die Szenarien voraus. Hierzu präsentieren wir Ansätze aus zwei Forschungsprojekten: Der erste Ansatz identifiziert gesellschaftliche Leitmotive der Energiewende und analysiert, in welchen technisch-ökonomischen Transformationspfaden diese realisiert werden können. Der zweite Ansatz setzt auf eine partizipative Entwicklung von Storylines, um eine verbesserte Legitimation und Kommunikation von Transformationspfaden zu erreichen. Wir diskutieren die Herangehensweisen beider Ansätze, die Positionen von Stakeholdern methodisch zu erfassen und mit technisch-ökonomischen Perspektiven zur Energiesystemtransformation zu verknüpfen.
Energiezukünfte für Power-to-X-Technologien
Authors: Epp Julia , Pfaff Theresa
Published: December 2019

In Power-to-X-Technologien (P2X) in Form von synthetischen Kraft- und Brennstoffen für die Energie- und Verkehrswende werden große Hoffnungen gesetzt, ob als Lösung für den Umgang mit der Volatilität der erneuerbaren Energien oder als Kraftstoffe für den Verkehr. Aufgrund der begrenzten Flächen- und Erzeugungspotenziale erneuerbarer Energien ist jedoch kein großflächiger Ausbau von P2X-Anlagen in Deutschland zu erwarten. Der Import von P2X-Stoffen für die künftige Energieversorgung aus dem Ausland könnte eine wichtige Strategie zur Dekarbonisierung des Energiesystems sein. Die Akzeptabilität dieser Energiezukünfte wird hinsichtlich sozialer und ökologischer Kriterien exploriert.
Perspektiva študentov zdravstvene nege do istospolno usmerjenih
Authors: Šavli Danijela , Ličen Sabina
Published: December 2019

Uvod: Istospolno usmerjeni posamezniki še danes znotraj zdravstvenega sistema večinoma niso nakopravno obravnavani. Namen raziskave je bil prepoznati znanja študentov zdravstvene nege o istospolno usmerjenih in stališča do njih.Metode: V opisni neeksperimentalni kvantitativni raziskavi sta bili uporabljeni v slovenščino prevedeni inačici vprašalnika: The Sex Education and Knowledge about Homosexuality, v slovenščini Vprašalnik o spolni vzgoji in znanju glede homoseksualnosti (Cronbach α = 0,97) in The Attitudes towards Homosexuals, v slovenščini. Vprašalnik o stališčih do homoseksualnosti (Cronbach α = 0,95). Sodelovalo je 70 študentov dodiplomskega študijskega programa Zdravstvena nega. Zbiranje podatkov je potekalo s pomočjo spletnega vprašalnika od junija do avgusta 2018. Podatki so bili analizirani z deskriptivno statistiko, Mann Whitneyevim U-testom, Kruskal Wallisovim H-testom, linearno regresijo in testom hi-kvadrat. Upoštevana stopnja statistične značilnosti je bila 0,05.Rezultati: Študenti izkazujejo nezadostno znanje o homoseksualnosti, saj so le na 6 vprašanj od 32 odgovorili pravilno. Ugotovitve kažejo, da pozitivno stališče do homoseksualnosti izražajo moški anketiranci (p < 0,05), študenti iz starostne skupine od 28 do 37 let, poročeni študenti, študenti katoliške vere in študenti 3. letnika. Vendar pri omenjenih  spremenljivkah razlike v stališčih med študenti niso statistično značilne (p ≥ 0,05).Diskusija in zaključek: Raziskava je pokazala, da študentom zdravstvene nege primanjkuje znanja o homoseksualnosti ter da imajo do nje negativen odnos. Da bi dosegli enakopravno obravnavo za vse paciente, so v izobraževanju za zdravstveno nego potrebne spremembe – vključitev vsebin, povezanih s kulturnimi kompetencami.
Factors affecting dental services accessibility
Authors: Forjanič Miran , Dermol Valerij , Prevolnik Rupel Valentina
Published: December 2019

Introduction: Access to dental services is a basic right included in the compulsory health insurance for patients and thus an important part of the healthcare system in Slovenia. The purpose of this research was to identify and explore the factors that have the greatest impact on the accessibility of dental services from the perspective of the system stakeholders in Slovenia.Methods: A qualitative study was conducted based on the focus group method. The focus group consisted of relevant system stakeholders, namely two representatives of the regulator, provider and payer, a total of six participants. A thematic analysis was carried out in order to identify the patterns and themes within thequalitative data obtained.Results: The results of the focus group revealed the views of system stakeholder on the accessibility of dental services in Slovenia. According to the system stakeholders' perspective, accessibility of dental services in Slovenia is not optimal and significant changes in terms of financing and organisation are required.Discussion and conclusion: We found that the lack of adequate human resources, insufficient health insurance and payment for services are the crucial factors in providing adequate access to dental health in Slovenia. In order to increase its accessibility, the dental programme needs to be expanded and the number of teams for its implementation increased.
Model Pembelajaran Bahasa Berbasis Riset melalui Analisis Framing
Authors: Suharyo Suharyo
Published: December 2019

This study aims to apply a number of language learning models in research-based tertiary institutions through framing analysis. Experimental learning models such as discovery learning, inquiry learning, dan problem based. The results of the teaching and learning process were responded well by a numbe r of students. The response, for example, is demonstrated through research (linguistic) using framing analysis for the final project preparation (thesis). Meanwhile, in the context of research: the methods used include: consider, record, with data analysis using framing analysis. The result: in framing both (Jokowi and Prabowo) there are similarities in terms of (1) protruding at the syntactic level, namely on the headline, (2) protruding on the script aspect, ie focusing on reporting, (3) highlighting on the aspect of the theme, namely in paragraphs, and (4) protruding on the rhetorical aspect, i.e. the photos displayed. In addition, there is a negative image of Prabowo more visible than in Jokowi.
Migratory state is not associated with differences in neural glucocorticoid or mineralocorticoid receptor expression in pine siskins
Authors: Watts Heather E. , Rittenhouse Jeffrey L. , Sewall Kendra B. , Bowers J. Michael
Published: December 2019

Although the endocrine system likely plays an important role in orchestrating the transition to a migratory state, the specific mechanisms by which this occurs remain poorly understood. Changes in glucocorticoid signaling are one proposed mechanism that may be important in migratory transitions. Although previous work has focused on the role of changes in circulating glucocorticoids, another potential mechanism is changes in the expression of its cognate receptors. Here, we test this hypothesis by comparing mRNA expression of the genes for the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in two brain regions implicated in the regulation of migratory behavior (the hippocampus and hypothalamus) in pine siskins (Spinus pinus) sampled before or after the transition to a spring nomadic migratory state. Compared to pre-migratory birds, migratory birds had body conditions more indicative of physiological preparations for migration (e.g., larger body mass), and greater levels of nocturnal migratory restlessness. However, we found no differences between pre-migratory and migratory birds in the expression of GR or MR mRNA in either the hippocampus or hypothalamus. Thus, differences in expression of receptors for glucocorticoids do not appear to underly the observed differences in physiology and behavior across a migratory transition. Taken together with previous results showing no change in circulating corticosterone levels during this transition, our findings provide no evidence for a role of glucocorticoid signaling in the spring migratory transition of this species.
Shareholder Wealth Maximization and Investment Decisions of Nigerian Food and Beverage Companies
Authors: Shodiya Olayinka Abideen , Sanyaolu Wasiu Abiodun , Ojenike Joseph Olushola , Ogunmefun Gbadebo Tirimisiyu
Published: December 2019

The study examines the effect of shareholder wealth maximization on investment decision in food and beverage companies listed in Nigeria. To achieve this, seven listed food and beverage companies were selected. The research adopted an ex post facto research design, while purposeful and stratified sampling techniques were used to select seven out of the fifteen companies in the food and beverage subsector. Data for the study were extracted from the annual reports and accounts of the sampled companies from 2008–2017. The result obtained from the regression analysis reveals that earnings per share and market price per share have no significant positive effect on investment decisions, while dividend per share was found to have no significant negative effect on investment decisions. In effect, the study concludes that the unique combination of the identified proxies for shareholder wealth maximization have jointly a significant positive effect on investment decisions. Arising from this, the study recommends that food and beverage companies should improve more on earnings per share, dividend per share, and market price per share so as to attract more investment from shareholders.
A comprehensive evaluation for the prediction of mortality in intensive care units with LSTM networks: patients with cardiovascular disease
Authors: Maheshwari Saumil , Agarwal Aman , Shukla Anupam , Tiwari Ritu
Published: December 2019

Intensive care units (ICUs) are responsible for generating a wealth of useful data in the form of electronic health records. We aimed to build a mortality prediction model on a Medical Information Mart for Intensive Care (MIMIC-III) database and to assess whether the use of deep learning techniques like long short-term memory (LSTM) can effectively utilize the temporal relations among clinical variables. The models were built on clinical variable dynamics of the first 48 h of ICU admission of 12,550 records from the MIMIC-III database. A total of 36 variables including 33 time series variables and three static variables were used for the prediction. We present the application of LSTM and LSTM attention (LSTM-AT) model for mortality prediction with such a large number of clinical variables dataset. For training and validation purpose, we have used International Classification of Diseases, 9th edition (ICD-9) codes for extracting the patients with cardiovascular disease, and infections and parasitic disease, respectively. The effectiveness of the LSTM model is achieved over non-recurrent baseline models like naïve Bayes, logistic regression (LR), support vector machine and multilayer perceptron (MLP) by generating state of the art results (area under the curve [AUC], 0.852). Next, by providing attention at each time stamp, we developed a model, LSTM-AT, which exhibits even better performance (AUC, 0.876).
Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus
Authors: Selbuz Suna , Buluş Ayşe Derya
Published: December 2019

Background

Various gastrointestinal (GI) symptoms are associated with diabetes. Common GI complaints associated with the manifestation of the disease include abdominal pain, diarrhea, nausea, bloating and vomiting. There have been very few studies examining GI problems of pediatric patients with type 1 diabetes mellitus (T1DM). The aims of this study were to find out the prevalence of GI symptoms in pediatric patients with T1DM and to determine the correlation among such symptoms, duration of diabetes and glycemic control.

Methods

One hundred and thirty-seven (median age 13.2 years, female 45.3%) patients with T1DM were examined. Demographic features, GI symptoms, signs and physical examination findings of the patients were recorded by pediatric gastroenterology specialists for the differential diagnosis and exclusion of other etiologies. Complete blood count, blood glucose, lipid profile, electrolytes, amylase, lipase, celiac antibodies and glycated hemoglobin (HbA1c) levels were evaluated and stool examination was performed. Endoscopy was performed on the patients who had refractory GI complaints. Gastric emptying (GE) time was evaluated using GE scintigraphy.

Results

Overall, 74 (54%) patients had ≥1 GI complaints. Patients often reported gastroesophageal reflux (32.8%) and abdominal pain (18%). The most significant findings in terms of GI symptoms were determined when patients were classified according to the glycemic control status. Reflux and dyspeptic symptoms were significantly more common in poorly or very poorly controlled diabetic patients (p=0.003 and p=0.004, respectively).

Conclusions

Diabetes can affect the entire GI tract, and GI symptoms are common in pediatric patients. We recommend that T1DM patients be evaluated for GI symptoms.
Messanlage zur Untersuchung des Seebeck-Effektes in Polymermaterialien
Authors: Jenschke Wolfgang , Ullrich Mathias , Krause Beate , Pötschke Petra
Published: December 2019

Der nach dem Physiker Thomas Johann Seebeck benannte thermoelektrische Effekt ist für alle wesentlichen Metalle hinreichend gut erforscht und wird seit langem unter anderem zur Temperaturmessung mittels Thermoelementen genutzt. Weniger bekannt und erforscht ist dieser Effekt in polymeren Werkstoffen, die aber heute auch in der Sensorindustrie immer mehr an Einfluss gewinnen. Im vorliegenden Artikel wird eine Messanlage beschrieben, die speziell für die Untersuchung des Seebeck-Effektes in polymeren Messobjekten mit dem Ziel aufgebaut wurde, maßgeschneiderte Polymere für sensorische technische Anwendungen zu entwickeln, die den Seebeck-Effekt nutzen. Die besonderen Anforderungen an die Messanlage liegen dabei in der Realisierung konstanter genauer Temperaturquellen.
INCLUSÃO ESCOLAR: DESAFIOS, ENTRAVES E POSSIBILIDADES NA SÍNDROME DE DOWN
Authors: Carneiro João Paulo
Published: December 2019

O texto em tela tem como principal finalidade refletir a respeito da educação especial, sobretudo na dimensão inclusiva (OMOTE, 1996; GLAT, FERNANDES, 2005; PELOSI, 2007; CIA, MENDES, PASIAN, 2014; MASCARO, 2018; TOGASHI, WALTER, 2016). Metodologicamente lançou-se mão do estudo de caso como pesquisa aplicada a casos concretos no âmbito do campo educacional, especialmente da instituição escolar (STAKE, 2011; YIN, 2001). A instituição escolar dar-se-á no âmbito da Educação Básica e sob a administração da 3ª Coordenadoria Regional de Educação (CRE), que se responsabiliza por um determinado grupo de instituições escolares da Secretaria Municipal de Educação do Rio de Janeiro (SME/RJ). Diante de inúmeros alunos NEE, reduziu-se a pesquisa ao aluno Edwards (nome fictício), pois, fora o único caso possível de contato, aluno com Síndrome de Down (SD). Mesmo diante dos entraves e desafios nos fora possível constatar e evidenciar potencialidades na esfera da inclusão escolar.
Arranjos Institucionais e Política Industrial de Defesa: construção de um modelo analítico
Authors: Ambros Christiano Cruz
Published: December 2019

O objetivo deste artigo é propor um modelo analítico para políticas de desenvolvimento da Base Industrial de Defesa (BID), principalmente políticas de aquisição e industriais de defesa, por meio do arcabouço conceitual dos arranjos institucionais. Utilizando-se de diferentes justificativas estratégicas – partindo da garantia da soberania, mas não se limitando a ela –, diversos países buscam desenvolver e consolidar uma indústria de defesa nacional. Aqueles países que se situam na camada intermediária da hierarquia global da indústria de defesa, como o Brasil, enfrentam constrangimentos estruturais para consolidar sua BID, entre eles o trilema da modernização da defesa. Para perpassar esses desafios, os países com BID mais consolidadas empregam uma série de políticas públicas, executadas por diferentes atores políticos e burocráticos e com variadas esferas de impacto. Neste artigo, exploramos as principais características e conceitos das políticas de aquisição e políticas industriais de defesa e avaliamos a literatura de arranjos institucionais enquanto ferramenta analítica, desenvolvendo um modelo de análise capaz de capturar diferentes facetas do fenômeno de forma integrada. Espera-se com este modelo contribuir para o avanço dos estudos comparados no campo de pesquisa da Economia de Defesa.
Introduction and evaluation of an interprofessional undergraduate simulation program in obstetrics and gynaecology - getting started and lessons learned
Authors: Joice Shannon , Coolen Jillian , Craig Catherine
Published: December 2019

Objective: Interprofessional education (IPE) occurs when two or more professions learn about, from and with each other to improve the quality of care. In Canada, the increasing need for IPE has been acknowledged on a national level.The objective of this project was to assess the implementation and evaluation of an interprofessional simulation curriculum in Obstetrics and Gynaecology (Ob/ Gyn) clerkship. Methods: Three obstetrical emergency simulations were presented to small interprofessional groups of undergraduate students (103): medicine (80), nursing (14), respiratory therapy (1), and paramedicine (8) between September 9, 2016 to August 8, 2017. A paper-based evaluation form was completed by all students.The purpose was to use this evaluation form to conduct a quality assurance review following the completion of the first year of this new interprofessional simulation program. Results: Ninety-nine percent of students indicated the session would benefit their clinical performance; 97.1% found the debriefing exercise helpful; 93% indicated the session was appropriate to their level of training; 98.1% felt it provided valuable team skills training; 92.2% indicated it helped them understand the roles of other health professionals; 96.1% indicated it helped improve collaborative leadership; and 87.1% noted a better understanding of the unique skillset of other health professionals.All students felt they were in a safe learning environment. Conclusion:To our knowledge, this is the first simulation program in Ob/Gyn clerkship in Canada designed to promote IPE amongst the four learner groups described above. Interprofessional simulation in Ob/Gyn Clerkship is valuable and well received by students from all health professional programs involved. It improves communication, role clarification, and collaboration.
World travel with type 1 diabetes using continuous subcutaneous insulin infusion
Authors: Charlton Alexander R , Charlton Jessica R
Published: December 2019

Living with type 1 diabetes and using continuous subcutaneous insulin infusion (CSII), the authors travelled together for four months through 11 countries. Travelling with type 1 diabetes presents various added challenges. Personal experience of the challenges faced by the authors in relation to their diabetes are discussed along with the ways they were able to overcome these challenges. A review of general aspects one may encounter when travelling with type 1 diabetes and CSII follows. This provides an insightful overview for individuals living with type 1 diabetes intending to travel as well as healthcare professionals involved in providing care to those with type 1 diabetes intending to travel.
Reductions in alanine aminotransferase levels with liraglutide treatment are greatest in those with raised baseline levels and are independent of weight loss: real-world outcome data from the ABCD Nationwide Liraglutide Audit
Authors: Crabtree Thomas SJ , Rowles Susannah , Tarpey Stephanie , Kennedy Adele , Chalmers John , Nayar Rahul , Lee Amanda , Darzy Ken , Winocour Peter , Lindsay John , Idris Iskandar , Thong Ken Y , Sen Gupta Piya , Puttanna Amar , Kumar Pranav , Ryder Robert EJ , Nationwide Audit Contributors On Behalf of ABCD
Published: December 2019

People with type 2 diabetes mellitus experience an increased prevalence of non-alcoholic fatty liver disease (NAFLD) compared with the general population and often with worse outcomes. As part of the ABCD Liraglutide Nationwide Audit Programme, we obtained and analysed data from 2009 to 2018 to assess the impact of liraglutide on alanine aminotransferase (ALT) levels as a marker of liver inflammation (often used in clinical trials as a marker of NAFLD). After excluding those with insufficient or incomplete data, we analysed the results from 1,759 patients treated in the real-world clinical setting. Our results demonstrated an overall significant decrease in median ALT (−1 U/L, 95% CI −1 to −2, p<0.001) compared with baseline, which was more pronounced in patients with elevated ALT based on gender- specific ranges (male: −4 U/L, 95% CI −3 to −6, p<0.001; female: −3 U/L, 95% CI −2 to −4, p<0.001). There was no correlation between weight loss and degree of ALT change (rho=−0.0002, p=0.41). Our data mirror outcomes from large randomised controlled trials and show that the impact of liraglutide on ALT is likely generalisable to real-world practice. Some of our data suggest that there may be a slight increase in ALT in those with normal levels at baseline, although the clinical significance of this is uncertain.
Glucose lowering strategies with insulin
Authors: Taylor M Joan , Chauhan Krishan P , Sahota Tarsem S
Published: December 2019

People with type 1 diabetes must use insulin and a large fraction of those with type 2 condition also do so. Many therefore struggle with the unpredictable balancing of insulin dose with calorie intake and utility. A healthy pancreas makes meticulous adjustment on a continuous basis that present therapeutic insulin administration cannot match. However, much progress has been made to make it simpler to inject both background and fast-acting boost insulins with a view to better mimicking normal pancreatic output. The present fast insulins are reviewed with accent on the primary amino acid structures of the biosynthetic types that diffuse more quickly than regular insulin that associates in hexamers. This makes boost doses kinetically and clinically more effective, allowing people to inject better estimated boost and corrective doses. Formulation advances are discussed for their present and potential contributions. The newer slow-acting insulins are also described and compared, their advantage also being kinetic with a lower likelihood of inducing overnight hypoglycaemia when used optimally. Finally, the appreciation of the advantages of alternative routes of administration such as oral and peritoneal are included in this review because of the possibility of altering the hepatic to peripheral ratio, the reasons for which are more effective but less obesogenic insulin activity. The logistics of oral insulin are summarised in terms of the risks to the insulin structure, the facilitation of paracellular uptake at the apical surface and the paradoxically advantageous hepatic first pass. Other non-invasive routes are also included in the review.
Wnt Signaling Drives Ectopic Gene Expression and Larval Arrest in the Absence of theCaenorhabditis elegansDREAM Repressor Complex
Authors: Cherian Jerrin R , Adams Katherine V , Petrella Lisa N
Published: December 2019

Establishment and maintenance of proper gene expression is a requirement for normal growth and development. The DREAM complex in Caenorhabditis elegans functions as a transcriptional repressor of germline genes in somatic cells. At 26°, DREAM complex mutants show increased misexpression of germline genes in somatic cells and High Temperature Arrest (HTA) of worms at the first larval stage. To identify transcription factors required for the ectopic expression of germline genes in DREAM complex mutants, we conducted an RNA interference screen against 123 transcription factors capable of binding DREAM target promoter loci for suppression of the HTA phenotype in lin-54 mutants. We found that knock-down of 15 embryonically expressed transcription factors suppress the HTA phenotype in lin-54 mutants. Five of the transcription factors found in the initial screen have associations with Wnt signaling pathways. In a subsequent RNAi suppression screen of Wnt signaling factors we found that knock-down of the non-canonical Wnt/PCP pathway factors vang-1, prkl-1 and fmi-1 in a lin-54 mutant background resulted in strong suppression of the HTA phenotype. Animals mutant for both lin-54 and vang-1 showed almost complete suppression of the HTA phenotype, pgl-1 misexpression, and fertility defects associated with lin-54 single mutants at 26°. We propose a model whereby a set of embryonically expressed transcription factors, and the Wnt/PCP pathway, act opportunistically to activate DREAM complex target genes in somatic cells of DREAM complex mutants at 26°.
Leveraging Family History in Case-Control Analyses of Rare Variation
Authors: Solis-Lemus Claudia R , Fischer S Taylor , Todor Andrei , Liu Cuining , Leslie Elizabeth J , Cutler David J , Ghosh Debashis , Epstein Michael P
Published: December 2019

Standard methods for case-control association studies of rare and common variation often treat disease outcome as a dichotomous phenotype. However, recent studies have demonstrated that cases with a family history of disease can be enriched...

Standard methods for case-control association studies of rare variation often treat disease outcome as a dichotomous phenotype. However, both theoretical and experimental studies have demonstrated that subjects with a family history of disease can be enriched for risk variation relative to subjects without such history. Assuming family history information is available, this observation motivates the idea of replacing the standard dichotomous outcome variable used in case-control studies with a more informative ordinal outcome variable that distinguishes controls (0), sporadic cases (1), and cases with a family history (2), with the expectation that we should observe increasing number of risk variants with increasing category of the ordinal variable. To leverage this expectation, we propose a novel rare-variant association test that incorporates family history information based on our previous GAMuT framework for rare-variant association testing of multivariate phenotypes. We use simulated data to show that, when family history information is available, our new method outperforms standard rare-variant association methods, like burden and SKAT tests, that ignore family history. We further illustrate our method using a rare-variant study of cleft lip and palate.
Sufrimiento social, VIH y narrativas en torno a la muerte en mujeres trans en Lima
Authors: Núnez-Curto Sifuentes Arón
Published: December 2019

Teniendo como contexto la reconstrucción etnográfica de las trayectorias de enfermedad, cuidado y fallecimiento de cuatro mujeres trans y travestis en la ciudad de Lima, este artículo busca analizar las narrativas en torno al VIH/sida, el cuidado de la salud, las maneras de afrontar la adversidad y la muerte presentes en las explicaciones y valoraciones de las mujeres trans y travestis que cuidaron de las fallecidas. Por un lado, las trayectorias ponen en discusión el impacto de la violencia institucional y las inequidades sociales en las limitadas posibilidades que tuvieron las fallecidas y sus redes de cuidado de afrontar los procesos de enfermedad producto de la infección avanzada por VIH. Asimismo, en las narrativas alrededor de lo sucedido, confluyen los efectos de una perspectiva neoliberal sobre el cuidado de la salud y una retórica del VIH/sida alrededor de la perspectiva del riesgo epidemiológico, discursos que hacen énfasis en la responsabilidad individual frente a la adversidad y la enfermedad. La narrativa sobre “la vida desordenada” es especialmente significativa, en tanto permite analizar la dinámica entre los efectos del VIH/sida como dispositivo de regulación y el estigma a la transgeneridad, como aspectos que producen sufrimiento y vulnerabilidad a mujeres trans y travestis.
Descripción del renacuajo de Telmatobius brachydactylus (Anura: Telmatobiidae)
Authors: Castillo Luis , Aguilar César
Published: December 2019

Se describe el renacuajo de Telmatobius brachydactylus desde el estadio 30 al 41 de Gosner. El renacuajo de T. brachydactylus es similar a las otras larvas de Telmatobius con morfología de tipo poza, pero se diferencia de la especie simpátrica, Telmatobius macrostomus, por tener la cola más larga en relación al cuerpo y una longitud total significativamente menor entre los estadios 33 y 41 de Gosner. Registramos por primera vez renacuajos de T. macrostomus y T. brachydactylus en sintopía.
The Chip and The Pale Truth by V. Zazubrin and Chocolate by A. Tarasov-Rodionov as “irrelevant” works: to the problem of “Red Terror” in the literature 1920s
Authors: Proskurina Elena
Published: December 2019

In the article, the problem of «red terror» is revealed in a little-known material. The story of the Siberian writer V. Zazubrin (1895–1937) The Pale Truth (1923) was published only once in Soviet times – in 1923 in the journal “Siberian Lights”; the novella “Sliver” (1923) was not published during the life of the author and was first published only in 1989. The story of A. Tarasov-Rodionov (1885–1938) Chocolate (1922) was reprinted several times in the 1920s, after which it was forgotten for decades. The work traces the history of the creation of the Chip, which until now contains many “white spots”. The originality of the plot is revealed, in which the image of the main character contradicts the canon of the “iron knight of the revolution”: tired of his firing “hard work”, he is going crazy. The typological similarity of the Chip with the story Chocolate is shown, the plot of which is also based on the dramatic story of the hero. Particular attention is paid to the receptive dialogue of the story The Pale Truth notch with Chocolate: in both works, heroes devoted to the cause of the revolution become its innocent victims.Both works echo and, in their pathos of justifying the “Red Terror”, the idea of “the future of beautiful humanity”. In terms of creative reception, the plot rolls of The Pale Truth with Chocolate, similarities in the images of the main characters and individual elements of poetics are shown. The “irrelevance” of Zazubrin and Tarasov-Rodionov’s works for Soviet literature is substantiated. The main factor is the discrepancy between their plots and the leading ideological maxims of the era.
Curtailing unconventional monetary policy: limitations and prospects
Authors: Sheludko Nataliia
Published: December 2019

The paper considers the monetary policy of leading world central banks that were used to overcome the global financial and economic crisis in 2008–2009. Advanced developed countries managed to overcome this crisis, primarily through monetary mechanisms. For this purpose, a non-traditional monetary policy was invented and applied for the first time. It included the following: quantitative easing with a corresponding rapid growth of central bank liabilities; de facto maintaining a plurality of their objectives, including ensuring financial stability and reducing unemployment; and expanded participation of central banks in financing governments' budget deficits. The measures taken helped to overcome the recession in developed countries and promoted the transition to a trajectory of economic growth. The current practice of monetary policy normalization, initiated in the United States, involves a gradual increase in the key interest rate and a curtailment of central bank balances. However, in many developed countries (EU), the practice of non-traditional monetary policy is still persistent and is an important factor for determining the trends of the global economy. In general, the results of this policy can be evaluated differently, but it is important for Ukraine to conclude on the relevance of monetary policy to stimulate economic development. Global volatility, increasingly determined by trade wars and other forms of protectionism in global economies, poses challenges (primarily in terms of maintaining/enhancing export and production capacity). For the economy of Ukraine, which is vulnerable to external shocks, these factors, combined with internal centres of instability, form a bunch of complicated tasks, in particular in terms of the cessation of further loss of investment potential, which should be addressed rationally by the monetary policy instruments.