bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of gully erosion on the territory of Tomsk using GIS technologies
Authors:   National Research Tomsk Polytechnic University, Tomsk, Russia, LEONOVA Anna Vladimirovna , STROKOVA Lyudmila Aleksandrovna ,   National Research Tomsk Polytechnic University, Tomsk, Russia
Published: April 2021

Relevance and purpose of the work. Currently, the area of development of Tomsk is increasing. New neighborhoods are growing on previously undeveloped land (for example, on the left bank of the river Tom). The central part of the city is being redeveloped and reconstructed. It is impossible to develop a high-quality territory without taking into account the dynamics, mechanisms, factors and patterns of development of dangerous natural and technological processes, the forecast of their development. The purpose of the work is to establish the patterns of gully erosion, assess the intensity of its development, and predict the probability of its occurrence within the new city boundaries. Methods of research. We performed an assessment and forecast of the development of gully erosion in Tomsk using GIS technologies, which are an important tool in the city management process due to their ability to process and analyze multidimensional data about the geological environment. We compared the traditional model of data-driven frequency ratio (FR) and expert-based multi-criteria assessment, i.e. analytical hierarchical process by weighting of gulley conditioning factors. Results of the work. We constructed a map of the distribution of gullies on the territory of the city, including 23 polygons. These polygons were then randomly divided into training (16 polygons or 70%) and validation data (7 polygons or 30%). We used seven gulley-conditioning factors for the two models to produce gulley susceptibility maps: slope angle, slope aspect, curvature, elevation, geological structure of the territory; types of filtration sections; distance to the river, to analyze the spatial patterns that determine the development of gully erosion. The spatial correlation between gulley locations and the conditioning factors were identified using GIS-based statistical models. We constructed gulley susceptibility maps based on the ranking of each factor by two methods using a training data set. Receiver operating characteristics (ROC) were used to validate the resulting susceptibility maps. The area under the curve (AUC) was 0.905 for the AHP model and 0,800 for the FR model, respectively, which indicates excellent and high quality of forecast maps. We proved that both methods are beneficial for assessment the susceptibility of the territory to gully erosion. We recommend using the constructed maps for regional planning and hazard mitigation, as well as in education by teaching the discipline “Engineering geodynamics”.
Upaya Membentuk Karakter Percaya Diri dan Kreatif Pada Anak Usia Dini Melalui Permainan Tradisional Jamuran
Authors: Mustakimah Mustakimah , Mu'amamah Sri
Published: April 2021

The background of this research is the importance of forming good character in early childhood with the stimulation given to traditional mushroom play activities. The method used in this study is a qualitative research method. The purpose of this study is to describe how the traditional game of mold can shape the character of early childhood. Based on the results of traditional game research, molds can form characters in early childhood, including honest characters formed by the habit of children not lying when guessed by their friends, disciplined characters are formed by habituating children to follow the rules in the game, respecting friends formed by habituating children do not choose -choose friends to be there next to him and listen to the instructions of friends in front, a confident character is formed by habituation of children giving instructions in the middle of their own, creatively formed by habituation of children mentioning names of objects or animals to imitate other friends, self-confidence and brave characters formed by habituation children advance in front of the crowd alone.
Perkembangan Kognitif Anak Usia Dini Penyandang Disleksia: Studi Kasus Pada Lembaga Pendidikan Di Indonesia
Authors: Filasofa Lilif Muallifatul Khorida , Miswati Miswati
Published: April 2021

Dyslexia is a disorder of the nervous system that is characterized by difficulty recognizing words both reading, spelling, understanding symbols and distinguishing letters. Dyslexic children experience barriers to cognitive development. Children tend to be slow in thinking and hard to understand things like counting, analyzing and understanding words. Some factors that cause children to experience dyslexia are educational, psychological and biological factors. But the main thing is neubiological factors or the brain. This is due to poor connectivity in the function of parts of the brain, namely the brocas, frontal lobe and cortex. Therefore parents or teachers need to implement appropriate strategies or handling methods so that the child's cognitive abilities can develop properly.
Uzupełnienie braku upoważnienia do asystowania przy zawieraniu małżeństwa wyrazem ochrony dobra wspólnego
Authors: Góralski Wojciech
Published: April 2021

Even though marriage arises from the consent of parties (can. 1057 § 1 of the Code of Canon Law), it is necessary to preserve the canonical form (ordinary or extraordinary) for the validity of this relationship.

Assuming that the form of marriage was established in order to eliminate secret marriages, canon 144 § 1 of the current Code of Canon Law states that in the event of factual or legal common error and in positive and probable doubt of law or of fact, the Church supplies executive power of governance for both the external and internal forum.

Canon 144 § of the same Code, on the other hand, declares that the same provision applies to the powers referred to, e.g. in canon 1111 § 1 of the Code of Canon Law. This canon regulates that a local ordinary can delegate (to priests and deacons) of assisting at celebrating marriages.

After discussing the role of a marriage witness and the character of his/her delegation as well as the development of legal form of supplying this delegation, the author takes up the issue of supplying this delegation in an event of common error or positive and probable doubt of law or fact in historical context, and then provides examples of supplying the delegation to assist in marriage in sentences of the Tribunal of the Roman Rota (from years 1992 -2006), including a precedent-setting sentence in the case of Stankiewicz of 15 December 1992.

In conclusion, attention was paid to the ratio legis of the legal norm on supplying the delegation, which is bonum commune.
Normy komplementarne do Kodeksu prawa kanonicznego z 1983 r. w sprawach małżeńskich Konferencji Episkopatów Stanów Zjednoczonych i Kanady
Authors: Adamczyk Jerzy
Published: April 2021

Celem artykułu jest ukazanie zagadnienia wydania przez konferencje biskupów Stanów Zjednoczonych i Kanady norm uzupełniających do Kodeksu prawa kanonicznego w kwestii małżeństwa. Autor przytacza i ocenia poszczególne normy komplementarne wydane przez konferencje episkopatu. Najpierw omawia się normy obligatoryjne, a następnie fakultatywne. Całość artykułu zamykają wnioski i bibliografia.
Istotne cele małżeństwa katolickiego
Authors: Smoliński Tomasz
Published: April 2021

Contemporary church legislation indicates two basic purposes of marriage: the good of the spouses and the birth of offspring. Today’s doctrine is based on the teaching of philosophers, theologians and doctors of the Church. In this work, considerations have been made regarding the important purposes of marriage, taking into account the views of scholars from ancient times, through the Middle Ages, to the Code of Canon Law of 1917, the Second Vatican Council and finally, the current Code of Canon Law of 1983.
Advances in Ethnobotany, Synthetic Phytochemistry and Pharmacology of
Endangered Herb Picrorhiza kurroa (Kutki): A Comprehensive Review
(2010-2020)
Authors: Mehta Sharuti , Sharma Anil Kumar , Singh Rajesh K.
Published: April 2021

:

Picrorhiza kurroa Royle ex Benth. (Family: Plantaginaceae) is a well-recognized Ayurvedic
herb. It is commonly called “Kutki” or “Kurro” and ‘Indian gentian’. Iridoid glycosides are the
plant’s bioactive constituents accountable for the bitter taste and medicinal properties of the plant. The
iridoid glycosides such as picrosides and other active metabolites of the plant exhibit many pharmacological
activities like hepatoprotective, antioxidant, anti-inflammatory, anticancer, immunomodulator,
anti-ulcerative colitis, antimicrobial, etc. This review aims to provide updated information on the ethnobotany,
synthetic phytochemistry, pharmacological potential, safety and toxicology of P. kurroa
and its active metabolites. Indiscriminate exploitation, ecological destruction of natural habitats, slower
plant growth and unawareness regarding cultivation and uprooting of plants have brought kutki an
endangered status. Therefore, various techniques used for the conservation and production of bioactive
metabolites from P. kurroa have also been reported. Information on the plant has been collected
from Science Direct, Google Scholar, PubMed, Scopus using ‘Picrorhiza kurroa’, ‘Picroside-‘,
‘Picroside-II’, ‘Picroliv’, ‘Immunomodulator’ keywords. All studies on ethnobotany, phytochemistry
and pharmacology of plant from 2010- 2020 were comprised in this review article. The possible directions
for future research have also been outlined briefly in this review article.
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review
Authors: Pachuta-Stec Anna
Published: April 2021

The information about the presence of free radicals in biological materials was given for the first time about 70 years ago. Since then, numerous scientific studies have been conducted and the science of free radicals was introduced. Today we know that free radicals are by-products of enzymatic reactions occurring in the organism. They are produced during endogenous processes such as cell respiration, phagocytosis, biosynthesis, catalysis, and biotransformation. They can also be produced by exogenous processes (radiation, sunlight, heavy metals, bacteria, fungi, protozoa, and viruses). The overproduction of free radicals affects the aging processes, Oxidative Stress (OS) and takes part in the pathogenesis of various diseases. Among them are cancer, rheumatoid arthritis, neurodegenerative diseases: Alzheimer and Parkinson, pulmonary diseases, atherosclerosis, and DNA damage. Compounds with antioxidant activity are very important nowadays because they allow organisms to keep a balance between the production of free radicals and the speed of their neutralization in the body. Next to the natural antioxidants (flavonoids, carotenoids, vitamins, etc.), synthetic ones are also of great importance. Among synthetic compounds with antioxidant activity are 1,2,4-triazoles and their derivatives. 1,2,4-Triazoles are heterocyclic compounds with three nitrogen atoms. Due to a broad spectrum of biological activities, these derivatives have been of interest to scientists for many years. Some of them are also used as drugs. The finding of new synthetic compounds with antioxidant features in the triazole group has become an important problem of medicinal chemistry.
Antioxidant, Anti-Inflammatory and Anticancer Activities of the Methanolic Extract of Thottea siliquosa: An In Vitro and In Silico Study
Authors: Koottasseri Amrutha , Babu Amal , Augustin Anna , Job Joice Tom , Narayanankutty Arunaksharan
Published: April 2021

Background:

Oxidative stress and inflammation are the predominant cause of chronic
diseases, including multiple forms of cancers. Prevention of oxidative stress and inflammation is
considered to be a target for preventing these disorders due to their significant roles in various degenerative
diseases. Various natural products and plant extracts prevent the process of free radical-
induced damages.

Objectives:

The present study evaluated the biological properties of Thottea siliquosa, belonging to
the family Aristolochiaceae, which is a traditionally used Ayurvedic plant.

Methods:

Antioxidant assays carried out were DPPH, FRAP, hydrogen peroxide scavenging, and
hemolysis inhibition assay; nitric oxide and lipoxygenase inhibition assays were used for anti-inflammatory
studies. Anticancer activity was evaluated using human endometrial and breast cancer
cells by MTT assay. Bioactive compounds present in T. siliquosa were identified by LCMS and
each was docked with various cancer targets, including EGFR, VEGFR, GST, COX2, and Lipooxygenase.

Results:

The results of the present study showed antioxidant properties of the methanolic crude extract
of T. siliquosa as DPPH radical scavenging (110.40 ± 4.5 μg/mL), FRAP capacity (41.1 ±
6.2), and peroxide scavenging (233.4 ± 14.2 μg/mL). Besides, anti-inflammatory properties were also
evident in terms of nitric oxide radical scavenging (28.76± 3.9 μg/mL) and lipoxygenase inhibition
(39.2 ± 3.2 μg/mL) assays. In silico analysis confirmed the inhibitory potential of the bioactive
compounds of T. siliquosa against cancer drug targets such as EGFR, VEGFR, and inflammatory
enzymes cyclooxygenase as well as lipooxygenase. Further, the anticancer activity of the extract
has been identified against human endometrial and breast cancer cells. The possible mechanism of
anticancer action of the extract is mediated through the apoptosis induction mechanism acting
through increased caspase and APAF-1 expressions.

Conclusion:

The study thus concludes that T. siliquosa showed significant antioxidant, anti-inflammatory
and anticancer properties. Further studies together with a bioassay-guided fractionation
may identify possible bioactive compounds.
Effect of Various Sequence Descriptors in Predicting Human Proteinprotein Interactions Using ANN-based Prediction Models
Authors: Dholaniya Pankaj Singh , Rizvi Samreen
Published: April 2021

Aims:

A number of sequence-based descriptors for proteins have been proposed by
many researchers. This study aims to evaluate the performance of these descriptors in predicting
protein-protein interactions on the benchmark dataset.

Background:

The behavior of a protein inside or outside the cell is defined by its interaction with
the elements present in the surrounding environment, which include small metabolites to the macromolecules
such as RNA, DNA, or proteins. Of these, understanding protein-protein interactions
(PPIs) is one of the important aspects to investigate the biological role of a protein. The interactions
of a protein are determined by how it folds in 3-dimensional space, and this threedimensional
folding of a protein largely depends on the linear sequence of amino acids. This information
makes it possible to exploit the sequences for proteins to computationally determine the
possible interactions among them.

Objective:

This study aims at studying the efficacy of various sequence-based descriptors in predicting
protein-protein interactions.

Methods:

In this study, we have used the benchmark dataset of interacting and non-interacting
protein pairs provided by Pan et al. to build the PPI prediction models using artificial neural networks.
We have compared the efficacy of different descriptors on two types of datasets, one with
all the protein pairs and the second with proteins having less than 25% identity.

Results:

The results show that conjoint-triad descriptors performed better than other descriptors in
predicting PPIs. The feature selection on the conjoint triad was performed and the effect on the
prediction model with reduced features versus all feature sets was studied.

Conclusion:

The classification model with conjoint-triad descriptors obtained the highest accuracy.
The feature ranking for the conjoint triad descriptor was utilized and the model performance
was compared with all and selected features. The model with reduced features shows less overfitting.
Zanthoxylum bungeanum Seed Oil Elicits Autophagy and Apoptosis in Human Laryngeal Tumor Cells via PI3K/AKT/mTOR Signaling Pathway
Authors: Bai Yun’e , Hou Jing , Zhang Xiao T. , Gao Jian P. , Zhou Jiang T.
Published: April 2021

Background:

Zanthoxylum bungeanum seed oil (ZBSO) is the main extract of the edible drug
Zanthoxylum bungeanum seeds. Recent reports have proved that it has a significant cytotoxic effect on various
cancer cells. However, systematic investigation on the role of ZBSO in laryngeal carcinoma (LC) is rare.

Objective:

The aim of the study was to reveal the function of ZBSO on human laryngeal squamous carcinoma
cells (Hep-2) and to elucidate its underlying mechanism.

Methods:

In this study, the chemical composition analysis of ZBSO was done using Ultra Performance Liquid
Chromatography (UPLC), and the anti-tumor effect of ZBSO on Hep-2 cells was evaluated by cell proliferation,
apoptosis and cell cycle experiments. qRT-PCR, immunohistochemistry (IHC) and Western blotting were used
for mechanistic investigation at the molecular level.

Results:

The main compound of ZBSO was identified as polyunsaturated fatty acids. Furthermore, as compared
to normal cells, significant inhibitory activities of ZBSO were observed on Hep-2 cells with dose- and timedependency,
which induced apoptosis, blocked cell cycle at the S phase, and inhibited cell proliferation. In
addition, IHC results showed a difference in the level of protein expression of ZBSO-induced autophagy-related
markers. At last, Western blotting results indicated that ZBSO could inhibit the expression and phosphorylation
levels of PI3K/AKT/mTOR protein.

Conclusions:

The anti-LC effect of ZBSO might be intimately associated with the induction of autophagy and the
inhibition of the PI3K/AKT/mTOR signaling pathway. ZBSO may be a potential anti-laryngocarcinoma agent.
SphK1 Promotes Cancer Progression through Activating JAK/STAT Pathway and
Up-Regulating S1PR1 Expression in Colon Cancer Cells
Authors: Long Jianting , Yao Zhijia , Sui Yi , Fang Shi
Published: April 2021

Background:

SphK1 is a conserved lipid kinase, which can catalyze the formation of tumorpromoting
factor sphingosine phosphate-1 (S1P).

Objective:

This study aimed to investigate the effect of SphK1 on the proliferation/migration of colon cancer
cells and associated mechanisms.

Methods:

Transcription of the SphK1 gene in colon cancer cells was detected. Gene transcription of SphK1 was
inhibited by transfecting with the si-SphK1 gene in colon cancer cells. Effects of SphK1 inhibition (si-SphK1) on
cell migration/proliferation were detected using the transwell system and MTS. Gene transcription of SIP,
S1PR1, S1PR2, S1PR3, and activation of JAK/STAT3 pathway were examined using RT-PCR and western blot
assay. S1PR1 over-expressing plasmid was constructed and transfected into cells. Effects of S1PR1 overexpression
on migration/proliferation of si-SphK1 transfected colon cancer cells and activation of JAK/STAT3
pathway were determined using RT-PCR and western blotting.

Results:

Gene transcription of SphK1 in SW480 and HT-29 colon cancer cells was significantly inhibited by
transfection of the si-SphK1 gene. Transwell migration and MTS findings showed that si-SphK1 transfection (si-
SphK1 group) could reduce migration quantity and cell viability of colon cancer cells compared to the negative
control (NC) (p<0.0001). SphK1 inhibition (si-SphK1 group) significantly down-regulated S1PR1 and S1PR3
gene transcription in SW480 and HT-29 cells (p<0.0001) and decreased activation level of JAKSTAT3 signaling
pathway compared to NC group (p<0.05). Over-expression of S1PR1 reversed inhibitory effects of si-SphK1 on
migration/proliferation of SW480 and activation of JAK/Stat3.

Conclusion:

SphK1 promoted proliferation and migration of colon cancer cells through promoting JAK/STAT
activation and up-regulating S1PR1 expression.
Prevention of Vancomycin-Induced Nephrotoxicity; An Updated Review
of Clinical and Preclinical Studies
Authors: Rahmani Hamid , Khalili Hossein
Published: April 2021

Purpose:

Clinical and preclinical evidences regarding new strategies for prevention of vancomycin-induced nephrotoxicity are reviewed.

Methods:

Evidence from 2014 to end of 2019 was included. Finally, twelve animal studies and one clinical trial were evaluated.

Results:

Although incidence of vancomycin-induced nephrotoxicity was not reduced significantly in the clinical trial, antioxidants reduced incidence of vancomycin-induced nephrotoxicity in preclinical studies.

Conclusions:

Antioxidants including vitamin C, vitamin E, cilastatin, melatonin, zingerone, rutin, naringenin, saffron, silymarin and dexmedetomidine were nephroprotective against vancomycin-induced nephrotoxicity in preclinical studies. The nephroprotective effects of these antioxidants must be confirmed before routine use in the clinical practice.
Is Priapism a Common Presentation of Chronic Myeloid Leukemia in an Adolescent Patient?
Authors: Purohit Abhishek H.L. , Sarangi Sujata , Kumar Deepak , Bohra Gopal K , Saha Souvik , Pandey Himanshu
Published: April 2021

Chronic myeloid leukemia (CML) is predominantly a disease of adults and the elderly.
CML is uncommon in the paediatric age. Priapism as an initial presentation is quite uncommon in
CML and is rare in the case of CML in paediatric and adolescent age. We present a case of CML in
an adolescent male who presented with priapism of 48 hours duration. The patient was managed in
an emergency by corporal aspiration and saline irrigation and was found to have CML during a hospital
stay. The patient was treated with imatinib and is under follow-up for the last two years.
Infectious and Non-infectious Factors Affecting Somatic Cell Count and New Diagnostic Approaches of Intramammary Infections in Dairy Goats: A Review
Authors: Margatho Gisele , Quintas Hélder , Rodríguez-Estévez Vicente , Simóes João
Published: April 2021

Background:

Intramammary infections constitute major animal health and economic
problem in commercial dairy goat farms, being responsible for decreases in milk yield, alter milk
composition, and lower milk quality.

Objectives:

This paper reviews the published literature during the last three decades, highlighting
the multiplicity of non-infectious and infectious factors that influence somatic cell count (SCC).
Besides that, it intends to contribute to understanding the conventional diagnostic methods and their
limitations, and supports the implementation of new technologies for efficient mastitis control, including
the use of infrared thermography and ultrasonography.

Methods:

A search on Medline, ScienceDirect, and University Institutional Repositories databases
was performed using “goats, AND mastitis OR intramammary infections OR somatic cells count”
for publications from 1990 to present (2020).

Results:

A total of 144 publications were selected. The SCC is the most important criteria to evaluate
the inflammatory status of the mammary glands in goats, but several non-infectious factors (e.g.,
phenotypic, reproductive, lactational factors) should be taken into consideration for its interpretation.
Bacteria and fungi as well as lentivirus are commonly responsive for intramammary infections.
Intermittent secretion or environmental contamination of milk pathogens, costs, and time delay poses
challenges using conventional diagnostic methods. Ultrasonographic and thermographic techniques
applied to the udder seem to be of diagnostic value in acute and chronic mastitis.

Conclusions:

Unlike other ruminants species, non-infectious factors have a major impact on SCC
which should be taken in account for mastitis diagnosis, and according to milk pathogens detection.
Further research in imagological techniques is needed to accurately contribute to implant new mastitis
control strategies.
Top-down and Bottom-up Approaches Revealed New Categories of Peptides
from the Venom of Moroccan Scorpion Androctonus mauretanicus
Authors: Daoudi Khadija , Malosse Christian , Darkaoui Bouchra , Chakir Salma , Chgoury Fatima , Cadi Rachida , Sabatier Jean-Marc , Chamot-Rooke Julia , Oukkache Naoual
Published: April 2021

Background:

Androctonus mauretanicus (Am ) is one of the most hazardous scorpions
in Morocco and has a highly toxic venom responsible for severe cases of envenomation. However,
few studies have focused on deciphering its proteic composition.

Objectives:

Herein, we aim to map out the complete proteome of the Am venom filtrate to highlight
its complexity and the polymorphism of its toxic content. This, in turn, will lead to a deeper understanding
of the toxins’ mechanism of action and will help uncover those with therapeutic potential.

Methods:

Top-down and bottom-up proteomic approaches were used complementarily to decipher
the proteome of the Am venom. These approaches were carried out on nano-high liquid chromatography
coupled to nano-electrospray tandem mass spectrometry (Nano-LC-ESI-MS/MS).

Results:

Am venom encloses a complex mixture of 269 different compounds with molecular
weights ranging from 1618.74 to 14 214.84 Da. The most abundant ones showed masses from
6185.92 to 7899.53 Da (53.89%) followed by those ranging from 2079.25 to 5969.63 Da (37.81%).
Interestingly, the combination of the results of both approaches allowed the screening of a total of
112 peptides. The highest percentage was represented by neuropeptides (87%), including NaTxs,
KTxs, ClTxs, venom proteins, venom neuropeptides, and myotropic neuropeptides. Moreover,
other peptides were identified, such as antimicrobial peptides, amphipathic peptides, cysteine-rich
venom peptides, enzymes, kunitz-type inhibitors and orphan peptides.

Conclusion:

The Am venom appears to contain a great number of diverse peptides, some of which
could prospectively be exploited for their pharmaceutical potential.
Photocatalysis
Authors: Kumar Amit
Published: April 2021

Photocatalysis is important in fighting environmental pollution, such as pharmaceutical effluents, dyes, pesticides and endocrine disruptors. It is also used for the production of clean energy, e.g. by way of hydrogen production from watersplitting, or CO2 conversion into fuels. Further, photocatalytic N2 fixation is promising for achieving sustainable ammonia synthesis. The book discusses new materials and reaction engineering techniques, such as heterojunction formations, composites, ion exchangers, photocatalytic membranes, etc.
Graphitic Carbon Nitride based Photocatalytic Systems for High Performance Hydrogen Production: A Review
Authors: Sharma S.
Published: April 2021

Pectin cerium(IV) iodate (PcCeI) and cerium(IV) iodate (CeI) cation ion exchange materials were synthesized via sol–gel methods. The materials were characterized by using Fourier transform infrared spectroscopy, X-ray diffractometer, thermogravimetric analysis, and scanning electron microscopy. The ion exchange capacity (IEC), thermal stability, distribution coefficient (Kd), and pH titrations were investigated to recognize the cation exchange behavior of the materials. The IEC of pectin-cerium(IV) iodate (PcCeI and cerium(IV) iodate CeI were reported as 1.80 meq/g and 0.92 meq/g, respectively. The higher distribution coefficient values of 250.01 and 219.14 mg/L confirmed the selectivity of pectin-cerium(IV) iodate hybrid ion exchanger for As3+ and Zn2+. The antibacterial activity of synthesized ion exchangers was explored for E. coli bacteria and observed relatively higher for PcCeI as compared to CeI.
Het monitoren van honden met diabetes mellitus
Authors: Willems A. , Smets P. , Van de Maele I. , Vandenabeele S. , Daminet S.
Published: April 2021

Diabetes mellitus is één van de meest voorkomende endocriene aandoeningen bij de hond. De diagnose kan vrij eenvoudig gesteld worden, maar de behandeling en voornamelijk het toepassen van een gepaste opvolging vormen een uitdaging. Het goed monitoren is belangrijk om complicaties, zoals hypoglycemie, gewichtsverlies, diabetes ketoacidose en urineweginfecties, te vermijden. Er bestaan verschillende methoden om een diabetespatiënt op te volgen: anamnese en lichamelijk onderzoek, éénmalige glucosebepaling, glucosedagcurves, fructosaminebepaling, geglyceerd hemoglobine, continuë glucosemetingen en glucosurie. De kunst is om aan de hand van een combinatie van deze technieken een goed beeld te krijgen van de glycemische status van de patiënt.
Gebruik van antivirale middelen in de diergeneeskunde
Authors: De Vleeschauwer A. , Lefebvre D. , De Clercq K.
Published: April 2021

De interesse voor het gebruik van antivirale geneesmiddelen in de diergeneeskunde neemt duidelijk toe. Tot op heden blijft de behandeling van virale infectieziekten in de diergeneeskunde beperkt tot het gebruik van enkele humane geneesmiddelen bij gezelschapsdieren, maar de ontwikkeling van specifieke diergeneeskundige middelen is aan de gang. Ook in de sector van de nutsdieren, waar virale infectieziekten kunnen leiden tot grote economische verliezen, is er toenemende interesse voor het gebruik van antivirale geneesmiddelen. De toediening van geneesmiddelen aan voedselproducerende dieren stelt echter specifieke eisen met betrekking tot farmacokinetiek, de uitwerking van maximale residulimieten (MRLs) en wachttijden, alsook (eco)toxiciteit. Ervaringen uit de humane geneeskunde leren dat de therapeutische doeltreffendheid van antivirale middelen soms negatief beïnvloed wordt door het ontstaan van minder gevoelige (resistente) virusvarianten. Bij de ontwikkeling van nieuwe antivirale producten is het dus van uitermate belang rekening te houden met de kans op antivirale resistentieontwikkeling. Dit is zeker het geval wanneer er wordt gedacht aan de grootschalige toepassing in de diergeneeskunde. In dit artikel wordt een korte inleiding gegeven over antivirale resistentieontwikkeling. Daarnaast wordt voor de meest voorkomende virale ziekten bij huisdieren een literatuuroverzicht gegeven van de mogelijke behandeling met chemische antivirale moleculen waarbij specifiek aandacht wordt besteed aan de beschikbare gegevens over antivirale resistentieontwikkeling. Het aantal studies over de effectiviteit van (humane) antivirale middelen tegenover diervirussen is beperkt en klinisch onderzoek limiteert zich meestal tot de werkzaamheid en toxiciteit. Er is een gebrek aan wetenschappelijke gegevens omtrent de dosering en de kans op resistentieontwikkeling van antivirale producten voor gebruik bij dieren. De bestrijding van virale dierziekten door middel van een antivirale therapie lijkt omwille van verschillende redenen aanlokkelijk, maar er is nog veel onderzoek vereist om tot een verantwoorde praktische toepassing te komen.
Het nut van intra-articulaire anesthesie als diagnosemiddel voor manken bij de hond
Authors: Van Vynckt D. , Samoy Y. , Mosselmans L. , Verhoeven G. , Verschooten F. , Van Ryssen B.
Published: April 2021

Manken bij de hond is soms moeilijk te lokaliseren omwille van weinig uitgesproken pathologische veranderingen of onduidelijke klinische symptomen. Intra-articulaire anesthesie wordt voorgesteld als een diagnostisch middel om het manken te lokaliseren. Na een beschrijving van de voorbereiding, de techniek en de punctieplaatsen, wordt een overzicht gegeven van een reeks patiënten aangeboden met verschillende gewrichtsproblemen. De studie gaf aan dat intra-articulaire anesthesie toepasbaar was in ieder gewricht, zolang de clinicus ervaring had en de honden gesedeerd waren. De intra-articulaire anesthesie was positief in 87% van de gevallen en problemen aan het ellebooggewricht, meer bepaald een losse processus coronoideus, was de grootste indicatie voor intra-articulaire anesthesie.
Intracraniaal oligodendroglioma met uitbreiding naar de nervus opticus bij een labrador retriever
Authors: Jeuring R. , Van Driessche K. , Bosseler L. , de Vries C. , Vanhaesebrouck A. , Gielen I. , Oevermann A. , Chiers K.
Published: April 2021

Een gecastreerde labrador retriever van zeven jaar oud werd aangeboden met klachten van abnormaal gedrag en een verminderd zicht. Op neurologisch onderzoek werd blindheid van het linkeroog gediagnosticeerd samen met een abnormaal bewustzijn. Bloedonderzoek en onderzoek van het cerebrospinaal vocht toonden geen afwijkende waarden. Op MRI werd een massa gelokaliseerd ter hoogte van de thalamus, de hypothalamus en de nucleus caudatus. Ook de linkernervus opticus leek betrokken in dit proces. Na een palliatieve behandeling gedurende 38 dagen werd de hond geëuthanaseerd en er werd een autopsie uitgevoerd. Hierbij werd een witte, zachte, uitpuilende, niet-omkapselde massa van 2 cm waargenomen. Deze massa was gelokaliseerd in de witte stof van de ventrale thalamusregio, dicht bij het chiasma opticum, en strekte zich uit langs de linkernervus opticus. Op histologisch onderzoek hadden de neoplastische cellen het uitzicht van “spiegeleieren”. Tussen deze cellen werden veel reactieve astrocyten waargenomen bij immunohistochemie. Het gezwel werd gediagnosticeerd als een astrocytenrijk oligodendroglioma graad II met invasieve groei in de linkernervus opticus.
Dermatitis ten gevolge van Devriesea agamarum en Nannizziopsis vriesii infecties bij hagedissen
Authors: Hellebuyck T. , Martel A.
Published: April 2021

Dermatitis is een van de meest frequent voorkomende aandoeningen bij in gevangenschap gehouden hagedissen. In dit overzicht worden twee infectieuze huidaandoeningen bij hagedissen in het bijzonder belicht: Devrieseasis en dermatomycose ten gevolge van infectie met het Chrysosporium anamorph van Nannizziopsis vriesii. Er wordt hierbij aandacht besteed aan de etiologie, diagnose, behandeling en preventie.
Paraprostaatcyste met urotheliale aflijning bij een hond
Authors: Cicchelero L. , Huyghe S. , Chiers K. , Volckaert V. , Melis S. , Paepe D. , Furcas A. , De Rooster H.
Published: April 2021

Een geïnfecteerde paraprostaatcyste met oorsprong in het prostaatparenchym werd gediagnosticeerd bij een zeven jaar oude, mannelijke, intacte Amerikaanse staffordshireterriër die aangeboden werd met dysurie. De diagnose werd gesteld aan de hand van de anamnese, het lichamelijk en echografisch onderzoek, het bacteriologisch onderzoek, het uitgebreid histopathologisch onderzoek en een DNA-test. De behandeling bestond uit het chirurgisch verwijderen van een groot deel van de cyste, omentalisatie van het restant gecombineerd met castratie en antibioticumtherapie. Immunohistochemische kleuringen toonden aan dat de cyste een urotheliale aflijning had. Een DNAtest sloot het persisterende-gang-van-Müller-syndroom (PMDS) uit. De cyste had een open verbinding met de urethra en ontstond vermoedelijk uit een embryonaal restant ter hoogte van de prostaat. De hond herstelde vlot van de ingreep maar de dysurie en incontinentie persisteerden. Bij de controle vier maanden postoperatief werd echografisch een nieuwe paraprostaatcyste aangetoond. Uit de echobegeleide punctie bleek de cyste geïnfecteerde urine te bevatten.
Andragogical Approach and Distance Learning Quality in PAUD Qolbun Salim Jatiendah Village, Cilengkrang District Bandung district
Authors: Suwarni Reni , Akhyadi Ade Sadikin , Saripah Iip
Published: April 2021

Abstract This study aims to describe the implementation, constraints, resistance, and factors that must be considered in Distance Learning through the andragogical approach in the 2019/2020 Academic Year at PAUD Qolbun Salim, Jatiendah Village, Cilengkrang District, Bandung Regency. The research subjects were 26 parents (mothers) during the Covid-19 pandemic. This research is exploratory with descriptive analysis. The results showed that the implementation of Distance Learning in PAUD Qolbun Salim through an andragogical approach was 92% followed, only 8% of parents (mothers) could not follow it. Of the 8% who cannot participate in PJJ, 4% are due to busy doing business online, and 4% are inadequate / decent cellphones. Constraints and resistance in implementing Distance Learning are related to infrastructure, parents' abilities and environmental conditions. Therefore the need for readiness from the institutions and parents, especially the availability of adequate learning facilities, infrastructure and the importance of an andragogical approach in the learning process.Key Words: Andragogical Approach, and Quality of Distance Learning.
PANDEMI COVID-19, PEMBERDAYAAN KELUARGA MELALUI PEMBUATAN PRODUK HOME INDUSTRY HAND SANITIZER ALAMI LIDAH BUAYA & DAUN SIRIH
Authors: Pratiwi Ane Lia
Published: April 2021

Penelitian ini dilaksanakan dalam rangka memberdayakan masyarakat agar tetap produktif dimasa pandemi Corona Virus Desease -19 (COVID-19) dengan meningkatkan keberdayaan masyarakat dalam menciptakan produk yang dapat membantu mengurangi angka penyebaran virus corona 19. Bencana non alam yang terjadi saat ini mengubah tatanan kehidupan. Kebutuhan akan pentingnya menjaga diri sendiri agar tidak terpapar virus menjadi sebuah keharusan. Kebutuhan alat pelindung diri yang praktis membuat tingginya permintaan handsanitizer dipasaran. Handsanitizer menjadi upaya dalam pencegahan virus corona. Dalam melengkapi kebutuhan terhadap handsanitizer tersebut dilakukanlah pemberdayaan ibu-ibu rumah tangga dalam mengembangkan produk handsanitizer home industry. Hal ini dilakukan dengan tujuan meningkatkan produktifitas Masyarakat dan memutus rantai penyebaran Virus Covid-19. Penelitian ini menggunakan metode kualitatif yang dengan pendekatan studi kasus.  Subjek penelitian ini adalah ibu-ibu rumah tangga di Puri Angreek. Hasil dari peneltiian ini adalah meningkatknya pengetahuan dan keterampilan ibu –ibu di bukit mekarwangi dalam  memanfaatkan peluang untuk dapat memenuhi kebutuhan public terhadap handsanitizer dan mengembangkan kapasitas diri agar tetap produktif dimasa pandemi.Kata Kunci : Pemberdayaan Masyarakat, Hand Sanitizer, Covid-19.
Nyi Pohaci Sang Hyang Sri Value in leader perspective of Cipatat Kolot Customary Societies
Authors: Bahagia Bahagia , Hudayana Bambang , Wibowo Rimun , Rangkuti Zulkifli
Published: April 2021

This research aims to investigate Nyi Pohaci Sang Hyang Asri's value in Cipatat Kolot societies perspective. The research method uses an ethnographic qualitative approach. This method is implemented because this research is linked to the social community. To gather data was used as an in-depth interview. Sample are selected through purposive technique. The result is probed meticulously through triangulation technique and triangulation sources. The result shows Nyi Pohaci Sang Hyang Asri is a customary society's faith. However, it becomes tradition and culture because the value of Nyi Pohaci pursues until nowadays generation. It has been embedded in their perspective. They must continue this perspective because it is mandatory from their forefather. While Nyi Pohaci release in proverb as non-material culture fro pursuing behavior in daily life. The other is Nyi Pohaci through traditional proverb which proverb has numerous meaning including they believe humans are in Nyi Pohaci and Nyi Pohaci are in human bodies. All parts of the human body, starting from human bones, human intellect, human flesh, human form, the hair on human bodies, bile in human stomachs, human minds and minds are formed by eating rice as Nyi Pohaci. As a result, the human dislikes the ravage nature environment because it has been cultivated on the land's surface. As land and nature are damaged, they have devastated Sri as paddies. It indicates that a human has influenced Nyi Pohaci belief must protect the natural environment. The other is they adjust their behavior not to adopt fully an-organic agriculture. They try to use composting and fertilizer for livestock manure. As a consequence, the soil can be preserved from damaged and combat global warming like climate change.
Realizing multiculturalism and social integration in Banuroja community
Authors: Noe Wahyudin , Wardhani Novia Wahyu , Umar Sitirahia Hi , Yunus Rasid
Published: April 2021

There have been many studies concerning Banuroja; however, there is always something novelty in creating a role model for village-based character education where the aim is to create a multicultural society into a multicultural community. This study examines community activities related to the national character values that embody multiculturalism and social integration in the Banuroja community. The method was qualitative with an ethnographic approach. Data were obtained from observations, interviews, and documentation carried out during 2019-2020. The validity of the data used triangulation, member checks, prolonged time, and peer debriefing. While the data analysis technique used ethnographic data analysis, namely describing, analyzing, and interpreting. The result shows that the realization of multiculturalism and social integration in the Banuroja community is carried out using three ways of assimilation, tolerance in beliefs/religions, appreciating other ethnic/religious activities by attending, and mutual cooperation. Guidance is also carried out through national and religious activities in the community, advice from parents in the family, and civic education in the schools, exemplary by community leaders, including ethnic, religious, and youth leaders.
REPRESENTASI HEGEMONI KINERJA POLRI DALAM PEMBERITAAN TEROR AIR KERAS NOVEL BASWEDAN DI KOMPAS.COM
Authors: Etikawati Dina
Published: April 2021

Berdasarkan analisis bahasa fungsional, pemakaian unsur gramatikal menggambarkan realitas sosial yang ada. Penelitian ini bertujuan untuk mendeskripsikan representasi kinerja kepolisian tentang kasus teror air keras Novel Baswedan dan upaya hegemoni dalam pemberitaan di kompas.com. Penelitian ini menerapkan pedekatan analisis wacana kritis model Fairclough. Data penelitian menggunakan pernyataan langsung kepolisian dalam pemberitaan di kompas.com. Data dikumpulkan dari edisi Mei 2017 s/d Desember 2019 yang diseleksi berdasarkan konteks penyelidikan kasus teror air keras Novel Baswedan. Penelitian ini menggunakan total 42 kutipan pernyataan langsung dari 18 teks berita yang dianalisis menggunakan metode abduktif inferen. Hasil penelitian sebagai berikut. Pertama, lembaga kepolisian diinterpretasikan memiliki kinerja sebagai berikut, bertanggung jawab yang direpresentasikan temuan proses material 39%, berkredibilitas direpresentasikan proses mental 30% dan proses verbal 14%, dan lembaga kooperatif direpresentasikan proses relasional 13% dan proses behavioral 4%. Kedua, pernyataan langsung Polri juga berfungsi sebagai upaya menghegemoni seperti, meyakinkan, mempengaruhi, dan mengontrol pihak lain.Kata kunci: representasi, kinerja, hegemoniTHE REPRESENTATION OF THE HEGEMONIC PERFORMANCE OF THE POLICE IN NOVEL BASWEDAN’S ACID ATTACK NEWS IN KOMPAS.COMAbstract Based on the analysis of functional language, the use of grammatical elements illustrates the existing social reality. This study aims to describe the representation of the police's performance in ivestigating the case of Novel Baswedan acid attack and the hegemony efforts in reporting in Kompas.com. This study applies the approach of analysis of Fairclough's critical discourse. The research data were taken from the police's direct statement in the news in Kompas.com. The data were collected from the May 2017 to the December 2019 editions and were selected based on the context of the investigation of Novel Baswedan’s acid attack. This study used a total of 42 direct statement excerpts from 18 news that were analyzed using inferent abductive methods. The research results are as follows. First, the police institution is interpreted to have responsible performance that is represented by the findings of the material process of 39%; credibility is represented by mental processes of 30% and verbal processes of 14%; and the cooperative institutions represent a relational process of 13% and behavioral processes of 4%. Second, The Police's direct statement also functions as an attempt to hegemony such as, convincing, influencing, and controlling other parties.Keywords: representation, performance, hegemony
IMPLEMENTASI BUDAYA DALAM PERKULIAHAN MENULIS AKADEMIK MAHASISWA BIPA TIONGKOK
Authors: Pujiono Setyawan , Widodo Pratomo
Published: April 2021

Upaya untuk mengenalkan budaya Indonesia kepada penutur asing (BIPA) dapat dilakukan melalui berbagai pendekatan. Salah satu pendekatan yang terbuka luas adalah melalui perkuliahan Menulis Karya Ilmiah (akademik). Tujuan penelitian ini untuk menguraikan implementasi budaya dalam perkuliahan menulis akademik mahasiswa BIPA dan mendeskripsikan topik terkait budaya Indonesia dalam produk karya tulis mahasiswa BIPA. Metode penelitian ini berdasarkan hasil observasi, wawancara, dan studi pustaka dalam proses perkuliahan menulis akademik mahasiswa BIPA. Hasil penelitian menunjukkan selama proses perkuliahan menulis akademik sudah berbasis budaya. Saat perkuliahan, dosen sudah menggunakan materi tentang budaya dan aktivitas mahasiswa (pemilihan ide, pengumpulan data, dan penulisan laporan) sudah beorientasi pada budaya Indonesia (khususnya budaya Jawa). Kemudian, topik produk tulisan mahasiswa juga berbasis budaya seperti perilaku hidup masyarakat Jawa, upacara tradisi, seni tradisi, dan benda-benda (artefak) budaya. Topik budaya dipilih oleh mahasiswa BIPA Tiongkok, karena: a) topik budaya sesuai pilihan mahasiswa, sehingga memotivasi belajar mereka, b) penelitian budaya merupakan materi otentik dan beraneka ragam jenisnya, c) budaya merupakan lahan tumbuhnya nilai-nilai dan kepribadian yang luhur dan mempercepat penyesuaian mahasiswa terhadap masyarakat lingkungannya.Kata kunci: budaya, menulis akademik, BIPAIMPLEMENTATION OF INDONESIAN CULTURE IN ACADEMIC WRITING CLASS OF CHINESE BIPA STUDENTSAbstractEfforts to introduce Indonesian culture to foreign speakers (BIPA) can be made through various approaches. One approach that is wide open is through lectures on Writing Scientific Papers (Academic Writing). The purpose of this study is to describe the implementation of cultures in the academic writing classes of BIPA students and to describe topics related to Indonesian cultures in the product of BIPA student research reports. The method of the study is based on the results of observations, questionnaires, and literature study in the academic writing process of BIPA students. The research results show that, during the lecture process, academic writing is based on culture. During classes, lecturers use material about students’ cultures and activities (idea selection, data collection, and report writing) which are oriented towards Indonesian cultures (especially Javanese cultures). Then, the topic of students’ writing is also based on cultures such as the behavior of the Javanese society, traditional ceremonies, traditional arts, and cultural objects (artifacts). The topic of the cultures is chosen by the Chinese BIPA students because: a) cultural topics are in accord with students’ choices, thus motivating their learning, b) cultural research is authentic material and has various types, c) culture is the land for the growth of noble values and personalities and accelerates the adjustment of students to their community.Keywords: culture, academic writing, BIPA