bluuebunny/crossref_metadata_2025 huggingface dataset:
Platelet activation in critically ill COVID-19 patients
Authors: Yatim Nader , Boussier Jeremy , Chocron Richard , Hadjadj Jérôme , Philippe Aurélien , Gendron Nicolas , Barnabei Laura , Charbit Bruno , Szwebel Tali-Anne , Carlier Nicolas , Pène Frédéric , Azoulay Célia , Khider Lina , Mirault Tristan , Diehl Jean-Luc , Guerin Coralie L. , Rieux-Laucat Frédéric , Duffy Darragh , Kernéis Solen , Smadja David M. , Terrier Benjamin
Published: July 2021

Background

Microvascular, arterial and venous thrombotic events have been largely described during severe coronavirus disease 19 (COVID-19). However, mechanisms underlying hemostasis dysregulation remain unclear.

Methods

We explored two independent cross-sectional cohorts to identify soluble markers and gene-expression signatures that discriminated COVID-19 severity and outcomes.

Results

We found that elevated soluble (s)P-selectin at admission was associated with disease severity. Elevated sP-selectin was predictive of intubation and death (ROC AUC = 0.67, p = 0.028 and AUC = 0.74, p = 0.0047, respectively). An optimal cutoff value was predictive of intubation with 66% negative predictive value (NPV) and 61% positive predictive value (PPV), and of death with 90% NPV and 55% PPV. An unbiased gene set enrichment analysis revealed that critically ill patients had increased expression of genes related to platelet activation. Hierarchical clustering identified ITG2AB, GP1BB, PPBP and SELPLG to be upregulated in a grade-dependent manner. ROC curve analysis for the prediction of intubation was significant for SELPLG and PPBP (AUC = 0.8, p = 0.046 for both). An optimal cutoff value for PBPP was predictive of intubation with 100% NPV and 45% PPV, and for SELPLG with 100% NPV and 50% PPV.

Conclusion

We provide evidence that platelets contribute to COVID-19 severity. Plasma sP-selectin level was associated with severity and in-hospital mortality. Transcriptional analysis identified PPBP/CXCL7 and SELPLG as biomarkers for intubation. These findings provide additional evidence for platelet activation in driving critical COVID-19. Specific studies evaluating the performance of these biomarkers are required.
Supplementation of a lacto-fermented rapeseed-seaweed blend promotes gut microbial- and gut immune-modulation in weaner piglets
Authors: Hui Yan , Tamez-Hidalgo Paulina , Cieplak Tomasz , Satessa Gizaw Dabessa , Kot Witold , Kjærulff Søren , Nielsen Mette Olaf , Nielsen Dennis Sandris , Krych Lukasz
Published: July 2021

Background

The direct use of medical zinc oxide in feed will be abandoned after 2022 in Europe, leaving an urgent need for substitutes to prevent post-weaning disorders.

Results

This study investigated the effect of using rapeseed-seaweed blend (rapeseed meal added two brown macroalgae species Ascophylum nodosum and Saccharina latissima) fermented by lactobacilli (FRS) as feed ingredients in piglet weaning. From d 28 of life to d 85, the piglets were fed one of three different feeding regimens (n = 230 each) with inclusion of 0%, 2.5% and 5% FRS. In this period, no significant difference of piglet performance was found among the three groups. From a subset of piglets (n = 10 from each treatment), blood samples for hematology, biochemistry and immunoglobulin analysis, colon digesta for microbiome analysis, and jejunum and colon tissues for histopathological analyses were collected. The piglets fed with 2.5% FRS manifested alleviated intraepithelial and stromal lymphocytes infiltration in the gut, enhanced colon mucosa barrier relative to the 0% FRS group. The colon microbiota composition was determined using V3 and V1-V8 region 16S rRNA gene amplicon sequencing by Illumina NextSeq and Oxford Nanopore MinION, respectively. The two amplicon sequencing strategies showed high consistency between the detected bacteria. Both sequencing strategies indicated that inclusion of FRS reshaped the colon microbiome of weaned piglets with increased Shannon diversity. Prevotella stercorea was verified by both methods to be more abundant in the piglets supplied with FRS feed, and its abundance was positively correlated with colonic mucosa thickness but negatively correlated with blood concentrations of leucocytes and IgG.

Conclusions

FRS supplementation relieved the gut lymphocyte infiltration of the weaned piglets, improved the colon mucosa barrier with altered microbiota composition. Increasing the dietary inclusion of FRS from 2.5% to 5% did not lead to further improvements.
Genetically Determined TSH Level Within Reference Range Is Inversely Associated With Alzheimer Disease
Authors: Li Gloria Hoi-Yee , Cheung Ching-Lung , Cheung Elaine Yun-Ning , Chan Wai-Chi , Tan Kathryn Choon-Beng
Published: July 2021

Context

Contradictory findings were reported in observational studies on the association of thyroid function (thyrotropin [TSH] and free thyroxine [FT4] levels) with Alzheimer disease (AD).

Objective

This work aims to determine whether genetically determined TSH/FT4 levels within reference range are causally associated with AD.

Methods

A bidirectional, 2-sample mendelian randomization (MR) study was conducted. With summary statistics from the largest genome-wide association studies (GWAS)/GWAS meta-analysis of TSH level(n ≥ 54 288), FT4 level(n = 49 269), and AD (71 880 cases; 383 378 controls), we used an MR approach to evaluate the bidirectional causal relationship between TSH/FT4 levels and AD. The inverse-variance weighted method was adopted as the main analysis.

Results

One SD increase in genetically determined TSH level within reference range was causally associated with a reduced risk of AD (odds ratio: 0.988; 95% CI, 0.977-0.998). A similar inverse association was observed in sex-specific analysis. The causal association was attenuated after adjustment for atrial fibrillation and blood pressure, suggesting they may mediate the causal pathway. A positive causal effect of AD on TSH level was detected only in male participants. This male-specific feedback loop may explain why the largest cohort study to date (Rotterdam Study) demonstrated a null observational association in men. Null association was observed between FT4 level and AD in both directions.

Conclusion

Genetic predisposition to increased TSH level, even within reference range, may lower the risk of AD, with atrial fibrillation, systolic, and diastolic blood pressure as possible mediators. Given the higher magnitude of risk reduction observed in the Rotterdam Study, whether the causal estimates derived from this MR study are underestimated warrants further investigation.
Luminescent Rhenium-containing Ionic Liquid Exhibiting Photoinduced Vapochromism
Authors: Cho Sok-Yong , Mochida Tomoyuki
Published: July 2021

A luminescent ionic liquid containing a cationic rhenium tricarbonyl complex was synthesized. UV photoirradiation of this liquid in the presence of an organic solvent vapor caused a color change and luminescence quenching via photochemical ligand exchange, thereby enabling the photocontrol of vapochromism.
Guanine-tethered Oligonucleotides Restore Abnormal Protein Synthesis with a SNP Mutation in a 5′-UTR G-quadruplex of Human MSH2
Authors: Hagihara Masaki , Shiroto Shuhei , Igarashi Shunya , Sato Shin-ichi
Published: July 2021

Here we demonstrate that a guanine-to-adenine substitution within guanine repeat sequences in the MSH 5′-UTR weakens G-quadruplex stability, leading to increased protein synthesis. The abnormal protein synthesis was effectively restored to the original level with a guanine-tethered oligonucleotide by the sequence-specific reintroduction of a hetero RNA–DNA G-quadruplex into the SNP site of the 5′ UTR of MSH2. Our approach would provide a new insight into gene therapies for various diseases which are caused by gene mutations in biological relevant G-quadruplexes.
A multidimensional quality model: an opportunity for patients, their kin, healthcare providers and professionals to coproduce health
Authors: Lachman Peter , Batalden Paul , Vanhaecht Kris
Published: July 2021

Background:It is twenty years since the US Institute of Medicine (IOM) defined quality in healthcare, as comprising six domains: person-centredness, timeliness, efficiency, effectiveness, safety and equity. Since then, a new quality movement has emerged, with the development of numerous interventions aimed at improving quality, with a focus on accessibility, safety and effectiveness of care. Further gains in equity and timeliness have proven even more challenging.

The challenge:With the emergence of “service-oriented” systems, complexity science, the challenges of climate change, the growth of social media and the internet and the new reality of COVID-19, the original domains proposed by the IOM invite reflection on their relevance and possibility for improvement.

The possible solution:In this paper, we propose a revised model of quality that is built on never-ending learning and includes new domains, such as Ecology and Transparency, which reflect the changing worldview of healthcare. We also introduce the concept of person- or “kin-centred care” to emphasise the shared humanity of people involved in the interdependent work. The change ofPerson Centred CaretoKin Centred Careintroduces a broader concept of the person and ensures that Person Centred Care is included in every domain of quality rather than as a separate domain. The concentration on the technological aspects of quality is an example of the problem in the past. This is a more expansive view of what “person-centredness” began. The delivery of health and healthcare requires people working in differing roles, with explicit attention to the lived realities of the people in the roles of professional and patient. The new model will provide a construct that may make the attainment of equity in healthcare more possible with a focus on kindness for all.
Case Report: Using basic liver function tests as a guide to suspected Wilson’s disease
Authors: Adhikari Sudeep , Shah Prashant Kumar , Sharma Yuba Raj
Published: July 2021

We present a case of a 36-year-old female patient who presented with subacute liver disease with a history of alcohol abuse. On basic liver function tests (LFT), she had aspartate transaminase / alanine transaminase > 2.2 and alkaline phosphatase / total bilirubin < 4. This pattern in acute liver failure patients signifies Wilson’s disease. Its presence in our patient with subacute liver disease also prompted us to suspect Wilson’s disease and we extended the liver disease screen to include slit lamp eye examination for Kayser-Fleischer rings, serum ceruloplasmin and 24-hour urinary copper level, which led to the diagnosis. She improved clinically and biochemically with zinc acetate therapy.  As screening for rare diseases is not always possible in low-income countries, this case demonstrates the usefulness of the basic LFT as a guide for suspecting Wilson’s disease in patients with liver disease.
Functional Reliability of the Employee in Operation Safety Management System Facilities for the Use of Nuclear Energy
Authors: Bobrov Alexandr , Sedin V. , Shcheblanov V. , Metlyaeva Nelya , Kalinina M.
Published: July 2021

Ensuring the safety of operation of particularly radiation-hazardous and nuclear-hazardous industries and facilities in the field of nuclear power is carried out using various methods, one of which is medical professional selection, selection and admission of personnel to perform official duties. The implementation of medical selection measures in the course of medical examinations using lists of medical contraindications is focused on the possibility of issuing permits to perform certain types of activities at the oiae to persons who do not have appropriate diagnoses. The presence of a disease included in the list of medical contraindications, detected during preliminary and periodic medical examinations and psychophysiological examinations, is evidence of late diagnosis and lack of data on pre-nosological disorders that are important for the selection and implementation of preventive rehabilitation and health measures. There was a need to introduce the concept of functional reliability (FR) and methods of its assessment into the practice of medical and psychophysiological support. FR is considered as a property of the functional systems of the employee's body to ensure the performance of prescribed job duties for a certain time and with a given quality, without reducing the psychophysiological adaptation (a person's systemic response to external and internal stimuli and factors aimed at achieving a useful adaptive result to an unacceptable level). The obtained data allowed us to draw a conclusion about the need to take into account the medical component of professional reliability – FR, along with assessments of the motives for choosing a profession and moral qualities, professional competence, compliance of psychological qualities and physical endurance with the requirements of the profession.
Nutraceutical use in osteoarthritic canines: a review
Authors: Williams Phillipa , Pettitt Rob
Published: July 2021

Osteoarthritis is prevalent in the UK canine population and has a clear impact on animal welfare. Treatment of osteoarthritis is advised to be multimodal, with nutraceuticals becoming a popular part of this approach. However, veterinary nutraceuticals are not subject to any regulation and systematic reviews are still uncommon in the veterinary field, which makes evaluating these products difficult. This article looks at the most commonly used veterinary supplements and how to critically evaluate the evidence of their efficacy. Evidence is promising for omega-3 fatty acids but is limited for other common ingredients. There are limited numbers of rigorous, randomised controlled trials and veterinary studies are often hampered by small sample sizes. Standardisation of reporting, as performed in human medicine, is needed to allow more robust systematic reviews of nutraceuticals to subsequently enable vets to make more informed decisions.
An update on interstitial lung disease
Authors: Mudawi D , Heyes K , Hastings R , Rivera-Ortega P , Chaudhuri N
Published: July 2021

Interstitial lung diseases are a complex group of conditions that cause inflammation and scarring of the lung interstitium. This article discusses the diagnosis and management of common interstitial lung diseases including idiopathic pulmonary fibrosis, hypersensitivity pneumonitis, connective tissue disease associated-interstitial lung disease, sarcoidosis and drug-induced interstitial lung disease. A multidisciplinary approach to diagnosis of interstitial lung disease is the gold standard; key history and examination features, blood panel, pulmonary function tests, high resolution computed tomography imaging, and when required bronchoalveolar lavage and lung biopsy results are discussed to reach a multidisciplinary consensus diagnosis. Advances, including the development of the disease-modifying anti-fibrotic medications nintedanib and pirfenidone, continue to shape the future management of interstitial lung disease. A holistic approach to the care of patients with interstitial lung disease is paramount, as they often have a high symptom burden and considerable palliative care needs.
The COVID-19 pandemic: the essential role of the voluntary sector in emergency response and resilience planning
Authors: Bynner Claire , McBride Maureen , Weakley Sarah
Published: July 2021

This research note highlights the need to engage the voluntary sector in strategic emergency response and resilience planning with the local state. It draws on qualitative fieldwork in two Scottish local authorities, which explored service responses to the COVID-19 pandemic in high-poverty neighbourhoods. The data comprised 25 interviews with front-line workers and senior managers in voluntary sector and public sector organisations. Interviews were conducted during the spring 2020 lockdown and subsequent easing of restrictions. The article employs Young’s (2000) models of government to analyse the relationship between voluntary organisations and the state. The findings indicate that this iterative crisis requires the relational skills of the voluntary sector to supplement the local state and provide a sustainable response to the needs of vulnerable populations. There is a need for a new strategic and complementary relationship, one that fully engages locally embedded voluntary organisations at all stages of emergency response and resilience planning.
Properties of polycapillary optics dedicated to low-energy parallel-beam wavelength-dispersive spectrometers for synchrotron-based X-ray fluorescence study
Authors: Jagodziński P. , Pajek M. , Banaś D. , Kubala-Kukuś A. , Szlachetko J. , Cotte M. , Salomé M.
Published: July 2021

The main advantage of wavelength-dispersive spectrometers applied in X-ray study is their high energy resolution. The design and construction of spectrometer, usually dedicated to the specific experimental systems, for example synchrotron based setups, need information about the characteristics of the main elements of the spectrometer such as X-ray optics elements, crystals and detectors. Such information can be obtained using Monte-Carlo simulations. In this paper, the Monte-Carlo simulations of X-ray tracing in parallel-beam wavelength-dispersive spectrometer (PBWDS), equipped with polycapillary optics, are presented and discussed. The study concentrates on the description of the polycapillary model, simulations of the properties of X-ray polycapillary optics and, finally, on the simulations of X-ray track in the spectrometer designed and installed at the ID21 beamline at the European Synchrotron Radiation Facility (ESRF, Grenoble, France). The results of simulations were compared with experimental data obtained for different registered X-ray energies and spectrometer crystals, showing good agreement. The obtained results showed that the X-ray transmission in the tested polycapillary optics is at the level of 15%, while the divergence of the outgoing beam changes from 8 mrad to 3 mrad with an increase of photon energy from 2 keV to 10 keV. The spectrometer provides an energy resolution of 5 eV and 33 eV in the energy range of 1.4 keV - 6.5 keV. The developed simulation program can be successfully used for the construction of spectrometers dedicated to the different experimental conditions.
Time-averaged image projection through a multimode fiber
Authors: Boonzajer Flaes Dirk , Štolzová Hana , Čižmár Tomáš
Published: July 2021

Many disciplines, ranging from lithography to opto-genetics, require high-fidelity image projection. However, not all optical systems can display all types of images with equal ease. Therefore, the image projection quality is dependent on the type of image. In some circumstances, this can lead to a catastrophic loss of intensity or image quality. For complex optical systems, it may not be known in advance which types of images pose a problem. Here we show a new method called Time-Averaged image Projection (TAP), allowing us to mitigate these limitations by taking the entire image projection system into account despite its complexity and building the desired intensity distribution up from multiple illumination patterns. Using a complex optical setup, consisting of a wavefront shaper and a multimode optical fiber illuminated by coherent light, we succeeded to suppress any speckle-related background. Further, we can display independent images at multiple distances simultaneously, and alter the effective sharpness depth through the algorithm. Our results demonstrate that TAP can significantly enhance the image projection quality in multiple ways. We anticipate that our results will greatly complement any application in which the response to light irradiation is relatively slow (one microsecond with current technology) and where high-fidelity spatial distribution of optical power is required.
Central retinal vascular trunk deviation in unilateral normal-tension glaucoma
Authors: Choung Ho-Kyung , Kim Martha , Oh Sohee , Lee Kyoung Min , Kim Seok Hwan
Published: July 2021

Purpose

To investigate whether the position of the central retinal vascular trunk (CRVT), as a surrogate of lamina cribrosa (LC) offset, was associated with the presence of glaucoma in normal-tension glaucoma (NTG) patients.

Methods

The position of the CRVT was measured as the deviation from the center of the Bruch’s membrane opening (BMO), as delineated by spectral-domain optical coherence tomography imaging. The offset index was calculated as the distance of the CRVT from the BMO center relative to that of the BMO margin. The angular deviation of CRVT was measured with the horizontal nasal midline as 0° and the superior location as a positive value. The offset index and angular deviation were compared between glaucoma and fellow control eyes within individuals.

Results

NTG eyes had higher baseline intraocular pressure (P = 0.001), a larger β-zone parapapillary atrophy area (P = 0.013), and a larger offset index (P<0.001). In a generalized linear mixed-effects model, larger offset index was the only risk factor of NTG diagnosis (OR = 31.625, P<0.001). A generalized estimating equation regression model revealed that the offset index was larger in the NTG eyes than in the control eyes for all ranges of axial length, while it was the smallest for the axial length of 23.4 mm (all P<0.001).

Conclusions

The offset index was larger in the unilateral NTG eyes, which fact is suggestive of the potential role of LC/BMO offset as a loco-regional susceptibility factor.
Meeting old friends for the first time: A personal reflection on the development of the Screenwriting Research Network
Authors: Macdonald Ian W.
Published: July 2021

A personal reflection on the origins and development of the Screenwriting Research Network, and of the discipline of screenwriting studies, from 2008–20.
Understanding Hezbollah symbolism through symbolic convergence theory
Authors: Matusitz Jonathan
Published: July 2021

This article applies symbolic convergence theory (SCT) to the type of symbolism used by Hezbollah, a Shia terrorist organization. By and large, SCT posits that sharing group fantasies contributes to symbolic convergence. The success of symbolic convergence hinges on three important concepts: symbolic cue, fantasy type and saga. An example of a symbolic cue is Hezbollah’s yellow-and-green logo that symbolizes global militancy against infidels. In regards to the organization’s fantasy types, eight of them were identified (e.g. Al-Quds Day, definition of enemies and individual self-sacrifice). Apropos of Hezbollah’s sagas, two figureheads, Ruhollah Khomeini (the Grand Ayatollah in Iran) and Hassan Nasrallah (the current Hezbollah leader), have become idols of worship by hundreds of thousands of Hezbollah members and millions of Shia Muslims. An important conclusion is that events can be more important for their symbolism than their very happening or existence. Hence, through symbolism, Hezbollah can strike a chord within its followers so as to produce significant change in the world.
La narrativa en los videojuegos: un espacio cultural de aprendizaje socioemocional
Authors: Esnaola Horacek Graciela Alicia , Levis Diego
Published: July 2021

De acuerdo con las investigaciones psicopedagógicas desarrolladas en el campo de los videojuegos (Esnaola Horacek, G. 2003, 2004, 2006, 2007; Frasca, G. 1997, 1999; San Martin Alonso, A. 2006; Levis, D. 2005, 2007; Gross, B. 2000; Ferrés, J. 2000) queda demostrada su intervención en los procesos de construcción de la identidad social de los jóvenes de estos tiempos. Sostenemos que los videojuegos, en tanto objetos culturales, conllevan una narrativa lúdica particular que remite a las características propias del contexto social que las diseña. Asumimos una postura crítica y valorativa de las posibilidades educativas que brindan los videojuegos deshechando argumentos funcionalistas que los señalan como propiciadores de conductas hiperviolentas o compulsivas. La propuesta lúdica y el relato que se despliega en estos particulares entornos interactivos constituyen un espacio cultural simbólico (Bourdieu 1990) privilegiado de simulación y construcción de la dinámica de las interacciones sociales y afectivas que es preciso comprender para incorporar a las propuestas educativas. Consideramos que es de suma importancia advertir el valor de las narrativas digitales para intervenir en ellas contribuyendo a la optimización y resguardo de la calidad de los productos que se ofrecen. Estas consideraciones brindarán orientaciones de interés para los desarrolladores, la industria de videojuegos como así también los consumidores de juegos en general.
Emociones con videojuegos: incrementando la motivación para el aprendizaje
Authors: González Carina S. , Blanco Francisco
Published: July 2021

Las emociones pueden influir positiva o negativamente en el aprendizaje y sobre todo en la motivación para aprender. Lograr que un alumno se sienta o no motivado a aprender “algo” es una de las claves del aprendizaje autónomo. Por ello, en este artículo se presenta el diseño y experimientación de un prototipo de videojuego 3D integrado en un aula virtual con alumnos universitarios, con el fin de estudiar cómo las emociones despertadas por los videojuegos pueden influir positiva o negativamente en la motivación hacia el aprendizaje. Hemos sustentado nuestra investigación en teorías correspondientes a interfaces afectivas, aprendizaje colaborativo apoyado con ordenadores (CSCL) y videojuegos; mientras que en el planteamiento metodológico del diseño y validación, hemos utilizado los fundamentos de la disciplina IPO (Interfaz Persona-Ordenador), en concreto, los principios del diseño centrado en el usuario (DCU). En la evaluación se ha analizado por qué se producían las emociones y por qué consideraban que incrementaba o no la motivación hacia la asignatura. Los resultados obtenidos indican que no sólo la motivación es beneficiosa para el aprendizaje, sino que también la frustración producida por los videojuegos puede ser utilizada para lograr una mayor persistencia en los logros de los objetivos de aprendizaje. Asimismo, descubrimos algunos problemas en la percepción de lo lúdico como una actividad de aprendizaje en la enseñanza superior.
Educación, heterogeneidad cultural e integración de las nuevas generaciones en un contexto global. El aporte de las tecnologías de la información y comunicación (TIC) para la transformación educativa en América Latina
Authors: Aparicio Pablo Christian , Silva Menoni María del Carmen
Published: July 2021

El movimiento de reformas educativas en América Latina derivó en nuevos desafíos sociales. Frente a la escasa capacidad de resolución de los problemas de inclusión e integración de las nuevas generaciones a la vida ciudadana, se plantea aquí la necesidad de espacios alternativos de expresión y participación juvenil. En este sentido, las nuevas tecnologías de la información y la comunicación (TIC) abren nuevas posibilidades para la formación democrática de los más jóvenes. Estas tecnologías, más cercanas a la realidad de los adolescentes y jóvenes, pueden promover la incorporación de herramientas de comunicación y participación más efectivas e inclusivas, en el seno de los procesos educativos. El presente artículo, es una invitación a habilitar el acceso a la tecnología digital al interior de las instituciones educativas y la creación de espacios (plataformas virtuales) y herramientas que posibiliten una mejor formación en la interacción y participación de los jóvenes, especialmente aquellos más urgidos de una mejor integración social.
Los patrones 'world cultural': Inequidades en la educación superior y las acciones afirmativas en Brasil
Authors: Parreira Do Amaral Marcelo
Published: July 2021

Este artículo discute la reciente introducción de cuotas para minoridades étnicas en las Universidades de Brasil bajo una perspectiva teórica diferente. En Brasil fueron adoptadas recientemente las políticas destinadas a disminuir las disparidades existentes en la participación a la educación superior por parte de los brasileros descendientes de africanos. Sin embargo la categoría “minoría étnica” es una categoría que para la auto percepción de los brasileros resulta poco clara, lo que provoca que dicha política tenga muchas desventajas para apoyar el acceso a la educación – en particular – y combatir la exclusión social en general, clase o raza. Considerando una directriz teórica relacionada a la globalización en general y particularmente a la teoría neo-institucional de ‘world polity’, el artículo sugiere considerar la adopción de las acciones afirmativas en las Universidades de Brasil como ejemplo del proceso de difusión de ideas y conceptos globales – o ‘world cultural’ – para lo nivel nacional. Como muestra la breve discusión de la implementación de las políticas afirmativas, questiones estructurales son tratadas solo marginalmente.
Trabajo social escolar desde la perspectiva de alumnas y alumnos en Alemania. Un ejemplo de Baden-Württemberg
Authors: Flad Carola , Bolay Eberhard
Published: July 2021

El Trabajo Social Escolar (Schulsozialarbeit) en Alemania se transformó desde hace aproximadamente 15 años en una de las ofertas más importante correspondientes a la Asistencia Social Juvenil (Jugenhilfe) y adquirió un perfil profesional importante. El presente aporte reconstruye a partir de una investigación cualitativa la perspectiva de los jóvenes y sus modelos subjetivos de adquisiciòn de competencias que son estructuradas a través de la organización institucional escolar. El valor de la operatividad del Trabajo Social Escolar se fundamenta en primer lugar en la relevancia de los profesionales entendidos como los portadores del sentido de la oferta de ayuda, en segundo lugar en la experiencias y relaciones realizadas en el proceso pedagógico cotidiano, en tercer lugar en la confianza de dichas referencias y en cuarto lugar a través de la experiencia se comprende que los temas correspondientes a su propia vida, adquieren significado. La interconección planteada entre la dimensión del uso y la dimensión de la empleabilidad (operatividad) confirma en quinto lugar la relevancia que posee la modulación de las relaciones pedagógicas entre las distintas generaciones como elemento estructural del Trabajo Social Escolar.
Elaboración de criterios pedagógicos para un mejor apro-vechamiento de los campus virtualesES
Authors: Reyero David , Morcillo J. Gabriel , Rodríguez Esther , Gil Fernando , Jover Gonzalo
Published: July 2021

Vivimos momentos de cambio en la Educación Superior. Por una parte el proceso de Bolonia y por otra el enorme desarrollo de las nuevas tecnologías marcan las prioridades organizativas de la situación actual. Las posibilidades que ofrecen las nueva tecnologías educativas son enormes pero si queremos extraer toda su utilidad no sólo es necesaria la continua mejora técnica sino también la reflexión teórica. Es precisamente ahora, un momento de cambios rápidos y de prisas, cuando puede resultar más acuciante pararse y pensar en el sentido de las prácticas docentes en nuestro mundo universitario actual. En este sentido, este artículo pretende analizar las posibilidades y condiciones, desde un punto de vista pedagógico, que permiten un mejor aprovechamiento de los entornos de aprendizaje combinado, a partir de la experiencia llevada a cabo en el Cam-pus Virtual de la Universidad Complutense de Madrid.
Educación ambiental mediante grupos de aprendizaje colaborativo en red una experiencia piloto para la construcción del EEES
Authors: Murga Mª Ángeles , Novo María , Melendro Miguel , Bautista-Cerro Mª José
Published: July 2021

En el marco de la actual reforma universitaria para armonizar la educación superior en los países miembros de la UE, uno de los retos más urgentes de los sistemas educativos consiste en equilibrar el fuerte sesgo profesionalizante de los nuevos modelos, concediendo a los aprendizajes éticos la prioridad que exige su decisiva importancia para la construcción de la ciudadanía europea. El proyecto de innovación docente que se presenta pretende contribuir a ello desde el ámbito de la Educación Ambiental y para el desarrollo sostenible, por medio de grupos de aprendizaje colaborativo en red. El estudio ha permitido explorar el uso de esta metodología en un sistema educativo no presencial y detectar algunas de sus fortalezas y debilidades. Se ha llevado a cabo en la UNED, universidad con amplia experiencia en el uso educativo de las tecnologías de la comunicación, en dos asignaturas de la Licenciatura de Pedagogía.
Innovación, investigación y cooperación universitaria en el espacio ALCUE
Authors: Gómez Gómez Francisco
Published: July 2021

El artículo abordará lo realizado en la segunda especialidad en “Orientación y Consejería al Niño, Adolescente y Psicoterapia Familiar” de la Universidad Nacional de San Agustín (UNSA) de Arequipa en el Perú, financiada por la Universidad Complutense de Madrid (UCM) como Proyecto de Ayuda al Desarrollo (II y IV convocatorias de proyectos de ayuda al desarrollo) y por la AECI (Agencia Española de Cooperación Inter-nacional) como Proyectos B/2403/05 y B/5933/06 para la movilidad del profesorado y la investigación conjunta entre la UCM y la UNSA La docencia es presencial y virtual a distancia mediante la utilización del Campus Virtual UCM y los estudiantes matriculados son graduados en Psicología, Psiquiatría, Medicina, Educación, Trabajo Social y Derecho.
Como acessar a caixa-preta do WhatsApp? Mapeamento dos métodos de publicações científicas que tratam sobre política em uma plataforma fechada de mídia digital
Authors: Bittencourt Filho Geraldo BulhÃµes , Rosa Jorge Martins
Published: July 2021

Neste artigo, buscou-se responder à pergunta “Quais são os métodos utilizados em artigos científicos sobre política que analisam empiricamente grupos e mensagens no WhatsApp?” Para isso, procurou-se efetuar uma revisão sistemática de literatura dentro das bases Scopus, Web of Science e Google Scholar, algumas das mais revisadas por pares da atualidade. Nelas, foram realizadas pesquisas que combinam a palavra WhatsApp com cada um dos seguintes termos: political, government, election e protest. Dos 51 resultados, identificou-se os métodos e a forma com a qual foi realizada a coleta de dados no WhatsApp. Conclui-se que há um equilíbrio entre abordagens e que não existe uma metodologia predominante para a coleta de dados.
Impact of Motor and Non-Motor Symptoms on Quality of Life in Parkinson’s Disease - A Questionnaire Based Observational Study from Karad, India
Authors: Kandharkar Samruddhi Sunil , Kashid Neha Arvind , Kanase Suraj Bhimrao , Mane Dhirajkumar A.
Published: July 2021

BACKGROUND Parkinson’s disease is a chronic neurodegenerative disorder with a prevalence rate of 108 - 257 per 100,000 people, occurring in later half of life and affecting both genders equally. The progressive nature of the disease is associated with growing disability and has a considerable impact on quality of life. Quality of life (QOL) is an important goal in every rehabilitation process and its impact on disease process, stage and prognosis is closely associated, which often gets neglected. Thus, it was necessary to conduct this study to establish actual impact of Parkinson’s disease on quality of life, emphasizing on disease duration. METHODS A questionnaire based observational study was carried out among patients with Parkinson’s disease in Maharashtra. The survey was conducted in Parkinson’s Association Group by handing over the hard copies of questionnaires to 120 patients and their respective care takers. Questionnaire used was ‘The Parkinson’s Disease Questionnaire (PDQ39)’. It had 39 items grouped into 8 domains. Statistical analysis of the collected data was carried out using InStat software and Microsoft excel. RESULTS In motor symptom-based questions, the impact on quality of life was more significant i.e., 54 % (P < 0.0001) compared to non-motor symptoms which was 46 % (P < 0.0001). Maximum number of subjects were from age group 71 to 80 while minimum number of subjects were from 91 to 100 yrs. CONCLUSIONS There was significant impact of motor as well as non-motor symptoms on patient’s quality of life; but motor symptoms like tremors and slowness of movement had greater impact compared to non-motor symptoms which included speech difficulty and social stigma. There was no co-relation between specific age group and incidence of disease. KEY WORDS Parkinson’s Disease, PDQ - 39 Questionnaire, Quality of Life (QOL), Motor and NonMotor Symptoms, Activities of Daily Living
Antifungal Effect of Hubballi Propolis on Candida albicans - An In Vitro Study
Authors: S Sowmya , Gujjari Anil Kumar , K.N Raghavendra Swamy
Published: July 2021

BACKGROUND As the longevity of human lives has increased, the geriatric population is increasing demonstrating more number of oral candidal infections due to decreased immunity. Natural products are being investigated to be used to treat oral candidiasis in place of synthetic drugs in selective geriatric cases. Propolis is one such natural product, which is time tested and developed by nature as an antimicrobial agent. Its toxicity is very less. It can be used in multiple forms. It has the antioxidant, anti-inflammatory properties apart from antibiotic properties and potency of the material improves as it matures with time. But the constituents of Propolis differ with the different sources of procurement. We wanted to evaluate the efficacy of the Propolis procured from Hubballi against Candida albicans in this study. METHODS In this invitro study, Hubballi Propolis was extracted by maceration and refluxing. Water and 70 % ethanol were used as extraction solvents. Total Phenolic and flavonoid contents were determined by using Folin - Ciocalteu spectrophotometric method and Aluminium chloride colorimetric method respectively. Antimicrobial sensitivity effect of Propolis was estimated by determining the minimum inhibitory concentration (MIC) of the samples. RESULTS The results of the studies revealed that propolis samples have effective antifungal activity against Candida albicans with MIC range from 0.01mg / ml to 0.03 mg / ml and comparable high total phenolic (TP) and total flavonoid (TF) contents ranging from 175.4 ± 5.7 to 192.2 ± 3.3 and 33.08 ± 10 to 31.73 ± 8.5 mg / ml respectively. CONCLUSIONS Hubballi Propolis can be used for treating Candidal infection. Further, water extract Propolis showed better in total phenolic content (TPC) and total flavonoid content (TFC) than the alcohol extract. This finding is important to overcome the disadvantage of alcohol extract and hence very useful for application in Dentistry, cosmetics and pharmaceutical industry. KEY WORDS Antifungal Activity, Hubballi Propolis, Flavonoid Content, Phenolic Content
Role of Finite Element Analysis in Oral and Maxillofacial Surgery - A Review
Authors: Anand Manish , Panwar Shreya , Bisht Srestha
Published: July 2021

BACKGROUND Maxillofacial surgeries vary from simple tooth extraction to maxillofacial reconstruction and rehabilitation. The intricate anatomy of the facial bones and complex vital structures surrounding them makes it challenging for the surgical teams to perform complex surgeries. With the rapid change in technology and modern advancement in virtual surgeries, there is a leap towards improvement in healthcare. To study biomechanical properties, it is imperative to include the principles of physical science in the field of medicine. In recent times, Finite element analysis (FEA) has become a useful tool to study the biomechanical properties of craniofacial structures under different mechanical parameters. Since the human structure's biomechanics is not possible to study on an experimental basis, finite element analysis has become an emerging tool to solve these complex biomechanical equations. The finite element method uses a numerical calculation of small heterogeneous geometry into the simple linear equation and predicts biomechanical responses towards each variation. Although used extensively in engineering, this method finds extensive use in the medical field, from planning surgeries to design external prosthesis. This method's most significant advantage includes studying a model outside the body, designing an idle surgical instrument and hardware, models that can be replicated based on user requirements, no ethical consideration needed, and print prosthesis that exactly resembles a typical anatomical structure. This method has certain limitations: high cost, technical flaws, and inability to replicate exact clinical conditions. This review article covers the current FEA scope in maxillofacial surgeries, steps in planning surgeries, advantages, disadvantages and the modifications needed to refine it for future research. KEYWORDS Finite Element Analysis, Craniomaxillofacial Trauma, Orthognathic Surgery, FEA
Traumatic Brachial Arteriovenous Fistula - History Also Matters
Authors: Das Debasish , Acharya Debasis , Singh Jogendra , Pramanik Subhas
Published: July 2021

Transradial intervention usually does not mandate history of arm or forearm injury; we report a case of traumatic AV fistula with focal narrowing of brachial artery for which right transradial angiogram could not be performed and coronary angiogram was accomplished from left transradial access. This rare case teaches us the fact that planning a transradial intervention also requires a history of trauma or surgical intervention to arm or forearm to avoid inadvertent complications during transradial access. Communication between an artery and a vein is known as arteriovenous fistula (AVF) which may be congenital, acquired or surgically created. Acquired arteriovenous fistula is most commonly due to traumatic injury. Following vascular injury, a hematoma develops locally, local healing and fibrosis leads to adhesion between artery and vein creating an arteriovenous fistula.1 Large arteriovenous fistula results in high output cardiac failure and rarely accounts for chronic ischaemia.2 Degree of arteriovenous shunting decides the timeframe of clinical presentation which is often subtle with delay in diagnosis. We report a case of post traumatic brachial AV fistula presenting with feeble pulse, difficult radial puncture and right transradial access failure with switch over to right transfemoral access for accomplishing coronary intervention.
¿Cómo co–construir y ejecutar agendas participativas hacia territorios más justos y sustentables? Procesos de investigación–acción en el Gran La Plata
Authors: Canevari Tomás
Published: July 2021

El artículo presenta dos conceptos emergentes de la praxis en procesos de extensión e investigación–acción en el Gran La Plata, Argentina: Agendas Científicas Participativas y Mesas de Trabajo Permanentes. Ambos se basan en diálogos de saberes a la vez que promueven y ejecutan acciones concretas con el objeto de acercar los deseos de la comunidad a políticas públicas más inclusivas, justas y sustentables. Sintetizan una perspectiva desde la comunicación y la educación popular que pretende superar instancias de la crítica y la resistencia para aportar a procesos de transformación. Frente a la multiplicidad de agendas sectoriales para abordar problemáticas territoriales, sociales y ambientales, se expone en este trabajo una iniciativa para producir conocimiento y promover la ejecución de acciones específicas con una perspectiva multidimensional junto a las comunidades implicadas.
Ambiente, extensión universitaria y pandemia: reconfiguraciones institucionales en Universidad Nacional del Litoral
Authors: Leguizamón Silvia , Sánchez María Luz , Heinrich Verónica
Published: July 2021

En esta presentación se comparten algunas de las acciones que se redefinieron en el marco de las políticas institucionales de extensión universitaria de la Universidad Nacional del Litoral, Argentina, frente al contexto de pandemia por COVID–19.Para la gestión universitaria, implicó profundizar el diálogo con organizaciones sociales y comunidades y redefinir metodologías y estrategias de trabajo. En este sentido, fue de vital importancia sostener las trayectorias de vínculos preexistentes y la articulación entre las diferentes áreas, programas y proyectos de extensión de la Secretaría de Extensión Social y Cultural.A partir de la lectura reflexiva del contexto se propone compartir el abordaje de las problemáticas ambientales locales a través del recorrido de dos proyectos de extensión con trayectoria y experiencia en el trabajo territorial. Reconfigurar los dispositivos académicos sigue siendo el principal desafío para la gestión de la extensión universitaria en trama colectiva con el territorio en pandemia.
Desain Laboratorium Pendidikan Berbasis Keterampilan Literasi Digital
Authors: Setiyawan Adhi
Published: July 2021

Digital literacy skills in learning services are needed during the COVID-19 Pandemic. The application of digital literacy in learning requires the support of long-term support unit stability. Many researchers have applied computers and information to improve learning, but research on supporting components and laboratory correlations as a support for the long-term stability of digital literacy is still scarce. The laboratory as a supporting unit has a strategic role in the development of digital literacy-based instructional services. This paper aims to conceptualize an Education Laboratory based on digital literacy skills in Indonesia. The concept of an educational laboratory is constructed using qualitative research methods through exploration involving the components of Lecturers, Schools, Students, and Pranata Lab, Department, and Faculties. The integrative framework for digital literacy at the micro and macro laboratory levels is the core of the discussion. The two basic strategies in this paper are the first strategy of the corelasional framework. The second strategy is regarding the conceptualization of the laboratory which is reduced to the function and scope of the laboratory. The findings of this paper are the Conceptualization of Educational Laboratories as academic support, research facilities, and public facilities.

Abstrak: Keterampilan literasi digital dalam layanan pembelajaran sangat dibutuhkan pada masa Pandemi COVID-19. Penerapan literasi digital pada pembelajaran membutuhkan dukungan stabilitas unit pendukung jangka panjang. Banyak peneliti telah mengaplikasikan komputer dan informasi dalam perbaikan pembelajaran, Namun penelitian komponen pendukung dan korelasi laboratorium sebagai pendukung stabilitas jangka panjang literasi digital masih langka. Laboratorium sebagai unit penunjang memiliki peran strategis dalam perkembangan layanan instruksional berbasis literasi digital. Makalah ini bertujuan mengonseptualisasi Laboratorium Pendidikan berbasis keterampilan literasi digital Perguruan Tinggi dan sekolah/madrasah. Konsep laboratorium pendidikan dikonstruk melalui metode penelitian mix method melalui penelitian korelasional dan eksplorasi melibatkan Dosen, Sekolah, Mahasiswa dan Pranata Laboratorium, Program studi dan Fakultas. Kerangka kerja integratif tingkatan mikro dan makro menjadi inti pembahasannya. Dua strategi dasar makalah ini adalah pertama korelasional. kedua konseptualisasi laboratorium yang direduksi menjadi fungsi dan ruang lingkup laboratorium. Temuan makalah ini adalah konsep laboratorium pendidikan sebagai pendukung akademik, fasilitas penelitian, dan layanan publik.