bluuebunny/crossref_metadata_2025 huggingface dataset:
Notch Transduction in Non-Small Cell Lung Cancer
Authors: Sharif Amnah , Shaji Ann , Chammaa May , Pawlik Eileen , Fernandez-Valdivia Rodrigo
Published: August 2020

The evolutionarily-conserved Notch signaling pathway plays critical roles in cell communication, function and homeostasis equilibrium. The pathway serves as a cell-to-cell juxtaposed molecular transducer and is crucial in a number of cell processes including cell fate specification, asymmetric cell division and lateral inhibition. Notch also plays critical roles in organismal development, homeostasis, and regeneration, including somitogenesis, left-right asymmetry, neurogenesis, tissue repair, self-renewal and stemness, and its dysregulation has causative roles in a number of congenital and acquired pathologies, including cancer. In the lung, Notch activity is necessary for cell fate specification and expansion, and its aberrant activity is markedly linked to various defects in club cell formation, alveologenesis, and non-small cell lung cancer (NSCLC) development. In this review, we focus on the role this intercellular signaling device plays during lung development and on its functional relevance in proximo-distal cell fate specification, branching morphogenesis, and alveolar cell determination and maturation, then revise its involvement in NSCLC formation, progression and treatment refractoriness, particularly in the context of various mutational statuses associated with NSCLC, and, lastly, conclude by providing a succinct outlook of the therapeutic perspectives of Notch targeting in NSCLC therapy, including an overview on prospective synthetic lethality approaches.
The Essential Role of Peptidylarginine Deiminases 2 for Cytokines Secretion, Apoptosis, and Cell Adhesion in Macrophage
Authors: Yu Hui-Chun , Tung Chien-Hsueh , Huang Kuang-Yung , Huang Hsien-Bin , Lu Ming-Chi
Published: August 2020

Objective: The study aims to investigate the functional roles of peptidylarginine deiminase 2 (PADI2) in macrophages. Methods: The clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein-9 nuclease (Cas9) system was used to knockout PADI2 in U937 cells. U937 cells were introduced to differentiate macrophages and were stimulated with lipopolysaccharides (LPS). The protein expression of PADI2, PADI4, and citrullinated proteins were analyzed by Western blotting. The mRNA and protein levels of interleukin 1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) were analyzed using RT-PCR and ELISA, respectively. Cell apoptosis was analyzed using flow cytometry. Cell adhesion assay was performed using a commercially available fibrinogen-coated plate. Results: PADI2 knockout could markedly suppress the PADI2 protein expression, but not the PADI4 protein expression. PADI2 knockout decreased the protein levels of citrullinated nuclear factor κB (NF-κB) p65, but not those of citrullinated histone 3, resulting in the decreased mRNA expression levels of IL-1β and TNF-α in the U937 cells and IL-1β and IL-6 in the differentiated macrophages and the macrophages stimulated with LPS. The cytokines levels of IL-1β, IL-6, and TNF-α were all dramatically decreased in the PADI2 knockout group compared with in the controls. PADI2 knockout prevented macrophages apoptosis via the decreased caspase-3, caspase-2, and caspase-9 activation. PADI2 knockout also impaired macrophages adhesion capacity through the decreased protein levels of focal adhesion kinase (FAK), phospho-FAK, paxillin, phospho-paxillin, and p21-activated kinase 1. Conclusion: This study showed that PADI2 could promote IL-1β, IL-6, and TNF-α production in macrophages, promote macrophage apoptosis through caspase-3, caspase-2, and caspase-9 activation and enhance cell adhesion via FAK, paxillin, and PAK1. Therefore, targeting PADI2 could be used as a novel strategy for controlling inflammation caused by macrophages.
Mitigating the Drying Shrinkage and Autogenous Shrinkage of Alkali-Activated Slag by NaAlO2
Authors: Chen Bin , Wang Jun , Zhao Jinyou
Published: August 2020

The shrinkage of alkali-activated slag (AAS) is obviously higher than ordinary Portland cement, which limited its application in engineering. In this study, the effects of NaAlO2 in mitigating drying shrinkage and autogenous shrinkage of AAS were studied. To further understand the shrinkage mechanism, the hydration products and microstructures were studied by X-ray diffraction, scanning electron microscopy and nitrogen adsorption approaches. As the partial substitution rate of NaAlO2 for Na2SiO3 increased, the drying shrinkage and autogenous shrinkage reduced significantly. The addition of NaAlO2 could slow down the rate of hydration reaction and reduce the porosity, change the pore diameter and the composition of generated paste and cause more hydrotalcite and tetranatrolite generated—which contributed to reduced shrinkage. Additionally, raising the Na2O content rate caused obvious differences in drying shrinkage and autogenous shrinkage. As the Na2O content elevated, the drying shrinkage decreased and autogenous shrinkage increased. A high Na2O content would cause complete hydration reactions and provoke high autogenous shrinkage. However, incomplete hydration reactions left more water in the paste, and the evaporated water dramatically influenced drying shrinkage. The results indicate that addition of NaAlO2 could greatly mitigate the drying shrinkage and autogenous shrinkage of AAS.
Microstructure and Optical Properties of E-Beam Evaporated Zinc Oxide Films—Effects of Decomposition and Surface Desorption
Authors: Skowronski Lukasz , Ciesielski Arkadiusz , Olszewska Aleksandra , Szczesny Robert , Naparty Mieczyslaw , Trzcinski Marek , Bukaluk Antoni
Published: August 2020

Zinc oxide films have been fabricated by the electron beam physical vapour deposition (PVD) technique. The effect of substrate temperature during fabrication and annealing temperature (carried out in ultra high vacuum conditions) has been investigated by means of atomic force microscopy, scanning electron microscopy, powder X-ray diffraction, X-ray photoelectron spectroscopy and spectroscopic ellipsometry. It was found that the layer deposited at room temperature is composed of Zn and ZnO crystallites with a number of orientations, whereas those grown at 100 and 200 ∘C consist of ZnO grains and exhibit privileged growth direction. Presented results clearly show the influence of ZnO decomposition and segregation of Zn atoms during evaporation and post-deposition annealing on microstructure and optical properties of zinc oxide films.
Effects of Chitosan–Gentamicin Conjugate Supplement on Non-Specific Immunity, Aquaculture Water, Intestinal Histology and Microbiota of Pacific White Shrimp (Litopenaeus vannamei)
Authors: Liang Fengyan , Li Chengpeng , Hou Tingting , Wen Chongqing , Kong Songzhi , Ma Dong , Sun Chengbo , Li Sidong
Published: August 2020

When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan–gentamicin conjugate (CS-GT) after Litopenaeus vannamei were infected with Vibrio parahaemolyticus, through nonspecific immunity parameter detection, intestinal morphology observation, and the assessment of microbial flora diversification by 16S rRNA gene sequencing. The results showed that the oral administration of CS-GT significantly increased total hemocyte counts and reduced hemocyte apoptosis in shrimp (p < 0.05). The parameters (including superoxide dismutase, glutathione peroxidase, glutathione, lysozyme, acid phosphatase, alkaline phosphatase, and phenoloxidase) were significantly increased (p < 0.05). The integrity of the intestinal epithelial cells and basement membrane were enhanced, which correspondingly alleviated intestinal injury. In terms of the microbiome, the abundances of Vibrio (Gram-negative bacteria and food-borne pathogens) in the water and gut were significantly reduced. The canonical correspondence analysis (CCA) showed that the abundances of Vibrio both in the water and gut were negatively correlated with CS-GT dosage. In conclusion, the oral administration of CS-GT can improve the immunity of shrimp against pathogenic bacteria and significantly reduce the relative abundances of Vibrio in aquaculture water and the gut of Litopenaeus vannamei.
A Multistep Iter for Functional Reconstruction in Mangled Upper Limb: A Retrospective Analysis of Integrated Surgical and Medical Approach
Authors: De Francesco Francesco , Marchesini Andrea , Campodonico Andrea , Neuendorf Alexander Dietrich , Pangrazi Pier Paolo , Riccio Michele
Published: August 2020

Background and objectives: Complex limb wounds with multiple tissue involvement are commonly due to high energy trauma. Tissue damage is a dynamic entity and the exact extent of the injury is rarely instantly perceptible. Hence, reconstruction frequently involves a multi-stage procedure concluding with tissue replacement. Materials and Methods: A retrospective study was conducted between 2006 and 2018 and included 179 patients with contaminated multi-tissue injuries treated with hyperbaric oxygen therapy, negative pressure therapy, physiotherapy and drug treatment associated with multiple surgical time in a multistep approach, focusing on pain levels and wound closure rates. Results: Despite the long-term response to traumatic events, a combined approach of delayed surgical reconstructive time in mangled upper limb yielded satisfactory functional outcomes. Conclusions: The complex upper limb wound with deep tissue exposure may be treated with a multi-stage procedure alternatively to immediate reconstruction. The integrated technique enables the preservation of existing healthy tissue and concurrent radical debridement, reducing the risk of infection, as well as avoiding the loss of free flaps and dehiscence due to incorrect wound estimation.
Multi-Enzymatic Cascade One-Pot Biosynthesis of 3′-Sialyllactose Using Engineered Escherichia coli
Authors: Li Zhongkui , Ni Zhijian , Chen Xiangsong , Wang Gang , Wu Jinyong , Yao Jianming
Published: August 2020

Among the human milk oligosaccharides (HMOs), one of the most abundant oligosaccharides and has great benefits for human health is 3′-sialyllactose (3′-SL). Given its important physiological functions and the lack of cost-effective production processes, we constructed an in vitro multi-enzymatic cofactor recycling system for the biosynthesis of 3′-SL from a low-cost substrate. First, we constructed the biosynthetic pathway and increased the solubility of cytidine monophosphate kinase (CMK) with chaperones. We subsequently identified that β-galactosidase (lacZ) affects the yield of 3′-SL, and hence with the lacZ gene knocked out, a 3.3-fold increase in the production of 3′-SL was observed. Further, temperature, pH, polyphosphate concentration, and concentration of divalent metal ions for 3′-SL production were optimized. Finally, an efficient biotransformation system was established under the optimized conditions. The maximum production of 3′-SL reached 38.7 mM, and a molar yield of 97.1% from N-acetylneuraminic acid (NeuAc, sialic acid, SA) was obtained. The results demonstrate that the multi-enzymatic cascade biosynthetic pathway with cofactor regeneration holds promise as an industrial strategy for producing 3′-SL.
Synthesis of Novel Sulfamethaoxazole 4-Thiazolidinone Hybrids and Their Biological Evaluation
Authors: Bhat Mashooq A. , Al-Omar Mohamed A. , Naglah Ahmed M. , Khan Azmat Ali
Published: August 2020

A search for potent antitubercular agents prompted us to design and synthesize sulfamethaoxazole incorporated 4-thiazolidinone hybrids (7a–l) by using a cyclocondensation reaction between 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (4), aryl aldehyde (5a–l), and mercapto acetic acid (6) resulting in good to excellent yields. All the newly synthesized 4-thiazolidinone derivatives were screened for their in vitro antitubercular activity against M. Bovis BCG and M. tuberculosis H37Ra (MTB) strains. The compounds 7d, 7g, 7i, 7k, and 7l revealed promising antimycobacterial activity against M. Bovis and MTB strains with IC90 values in the range of 0.058–0.22 and 0.43–5.31 µg/mL, respectively. The most active compounds were also evaluated for their cytotoxicity against MCF-7, HCT 116, and A549 cell lines and were found to be non-cytotoxic. Moreover, the synthesized compounds were also analyzed for ADME (absorption, distribution, metabolism, and excretion) properties and showed potential as good oral drug candidates.
Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated 188Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor
Authors: Lin Bing-Ze , Wan Shen-Ying , Lin Min-Ying , Chang Chih-Hsien , Chen Ting-Wen , Yang Muh-Hwa , Lee Yi-Jang
Published: August 2020

Hypopharyngeal cancer (HPC) accounts for the lowest survival rate among all types of head and neck cancers (HNSCC). However, the therapeutic approach for HPC still needs to be investigated. In this study, a theranostic 188Re-liposome was prepared to treat orthotopic HPC tumors and analyze the deregulated microRNA expressive profiles. The therapeutic efficacy of 188Re-liposome on HPC tumors was evaluated using bioluminescent imaging followed by next generation sequencing (NGS) analysis, in order to address the deregulated microRNAs and associated signaling pathways. The differentially expressed microRNAs were also confirmed using clinical HNSCC samples and clinical information from The Cancer Genome Atlas (TCGA) database. Repeated doses of 188Re-liposome were administrated to tumor-bearing mice, and the tumor growth was apparently suppressed after treatment. For NGS analysis, 13 and 9 microRNAs were respectively up-regulated and down-regulated when the cutoffs of fold change were set to 5. Additionally, miR-206-3p and miR-142-5p represented the highest fold of up-regulation and down-regulation by 188Re-liposome, respectively. According to Differentially Expressed MiRNAs in human Cancers (dbDEMC) analysis, most of 188Re-liposome up-regulated microRNAs were categorized as tumor suppressors, while down-regulated microRNAs were oncogenic. The KEGG pathway analysis showed that cancer-related pathways and olfactory and taste transduction accounted for the top pathways affected by 188Re-liposome. 188Re-liposome down-regulated microRNAs, including miR-143, miR-6723, miR-944, and miR-136 were associated with lower survival rates at a high expressive level. 188Re-liposome could suppress the HPC tumors in vivo, and the therapeutic efficacy was associated with the deregulation of microRNAs that could be considered as a prognostic factor.
Construction of Zn(II) Linear Trinuclear Secondary Building Units from A Coordination Polymer Based on α-Acetamidocinnamic Acid and 4-Phenylpyridine
Authors: Ejarque Daniel , Calvet Teresa , Font-Bardia Mercè , Pons Josefina
Published: August 2020

The synthesis and characterization of one coordination polymer and two trinuclear complexes are presented. The coordination polymer [Zn2(µ-O,O’-ACA)2(ACA)2(4-Phpy)2]n (1) has been obtained by the reaction between Zn(OAc)2·2H2O, α-acetamidocinnamic acid (HACA), and 4-phenylpyridine (4-Phpy) using EtOH as solvent. Its recrystallization in CH3CN or EtOH yields two trinuclear complexes, both having pinwheel arrays with formulas [Zn3(µ-ACA)6(4-Phpy)2]·4CH3CN (2·4CH3CN) and [Zn3(µ-ACA)6(EtOH)2]·4EtOH (3·4EtOH), respectively. These trinuclear species, unavoidably lose their solvent co-crystallized molecules at RT yielding the complexes [Zn3(µ-ACA)6(4-Phpy)2] (2) and [Zn3(µ-ACA)6(EtOH)2] (3). In addition, compound 2 has also been obtained reacting Zn(OAc)2·2H2O, HACA, and 4-Phpy in a 1:2:2 ratio using CH3CN as solvent. Compounds 1–3 have been characterized by analytical and spectroscopic techniques. Furthermore, single crystals suitable for X-ray diffraction method for compounds 1, 2·4CH3CN, and 3·4EtOH were obtained and their supramolecular interactions have been studied and discussed, showing 2D supramolecular planes for the trinuclear complexes and a 3D supramolecular network for the coordination polymer. Finally, the supramolecular interactions of 2·4CH3CN and 3·4EtOH have been compared using Hirshfeld surface analysis and electrostatic potential calculations.
Characterization of the Aroma of an Instant White Tea Dried by Freeze Drying
Authors: Ni Hui , Jiang Qing-Xiang , Zhang Ting , Huang Gao-Ling , Li Li-Jun , Chen Feng
Published: August 2020

The aroma of an instant white tea (IWT) was extracted through simultaneous distillation–extraction (SDE) and analyzed by sensory evaluation, gas chromatography-mass spectrometry-olfactometry (GC-MS-O), aroma reconstruction, omission test and synergistic interaction analysis. Sensory evaluation showed the IWT was dominated with floral and sweet notes. The SDE extract had the aroma similar to the IWT. The main volatile components in the SDE extract were benzyl alcohol, linalool, hotrienol, geraniol, α-terpineol, coumarin, camphene, benzeneacetaldehyde, 2-hexanone, cis-jasmin lactone and phenylethyl alcohol. GC-MS-O and aroma reconstruction experiments showed 16 aroma-active compounds. Linalool, trans-β-damascenone and camphene were the major contributors to floral, sweet and green notes based on flavor dilution analysis and omission test. Linalool and trans-β-damascenone had synergistic effect to promote floral and sweet notes. Camphene and trans-β-damascenone had synergistic effect to reduce green and sweet notes. The study helps to understand the aroma of IWT and antagonism interactions among aroma-active volatiles.
The Fuzziness in Molecular, Supramolecular, and Systems Chemistry
Authors: Gentili Pier Luigi
Published: August 2020

The global challenges of the XXI century require a more in-depth analysis and investigation of complex systems [...]
Ovine Bone Morphology and Deformation Analysis Using Synchrotron X-ray Imaging and Scattering
Authors: Statnik Eugene S. , Salimon Alexey I. , Besnard Cyril , Chen Jingwei , Wang Zifan , Moxham Thomas , Dolbnya Igor P. , Korsunsky Alexander M.
Published: August 2020

Bone is a natural hierarchical composite tissue incorporating hard mineral nano-crystals of hydroxyapatite (HAp) and organic binding material containing elastic collagen fibers. In the study, we investigated the structure and deformation of ovine bone by the combination of high-energy synchrotron X-ray tomographic imaging and scattering. X-ray experiments were performed prior to and under three-point bending loading by using a specially developed in situ load cell constructed from aluminium alloy frame, fast-drying epoxy resin for sample fixation, and a titanium bolt for contact loading. Firstly, multiple radiographic projection images were acquired and tomographic reconstruction was performed using SAVU software, following segmentation using Avizo. Secondly, Wide Angle X-ray Scattering (WAXS) and Small Angle X-ray Scattering (SAXS) 2D scattering patterns were collected from HAp and collagen. Both sample shape and deformation affect the observed scattering. Novel combined tomographic and diffraction analysis presented below paves the way for advanced characterization of complex shape samples using the Dual Imaging and Diffraction (DIAD) paradigm.
The Design of Large Scale IP Address and Port Scanning Tool
Authors: Yuan Chao , Du Jinze , Yue Min , Ma Tao
Published: August 2020

The control network is an important supporting environment for the control system of the heavy ion accelerator in Lanzhou (HIRFL). It is of great importance to maintain the accelerator system’s network security for the stable operation of the accelerator. With the rapid expansion of the network scale and the increasing complexity of accelerator system equipment, the security situation of the control network is becoming increasingly severe. Port scanning detection can effectively reduce the losses caused by viruses and Trojan horses. This article uses Go Concurrency Patterns, combined with transmission control protocol (TCP) full connection scanning and GIMP Toolkit (GTK) graphic display technology, to develop a tool called HIRFL Scanner. It can scan IP addresses in any range with any ports. This is a very fast, installation-free, cross-platform IP address and port scanning tool. Finally, a series of experiments show that the tool developed in this paper is much faster than the same type of software, and meets the expected development needs.
Predicting Venue Popularity Using Crowd-Sourced and Passive Sensor Data
Authors: Timokhin Stanislav , Sadrani Mohammad , Antoniou Constantinos
Published: August 2020

Efficient and reliable mobility pattern identification is essential for transport planning research. In order to infer mobility patterns, however, a large amount of spatiotemporal data is needed, which is not always available. Hence, location-based social networks (LBSNs) have received considerable attention as a potential data provider. The aim of this study is to investigate the possibility of using several different auxiliary information sources for venue popularity modeling and provide an alternative venue popularity measuring approach. Initially, data from widely used services, such as Google Maps, Yelp and OpenStreetMap (OSM), are used to model venue popularity. To estimate hourly venue occupancy, two different classes of model are used, including linear regression with lasso regularization and gradient boosted regression (GBR). The predictions are made based on venue-related parameters (e.g., rating, comments) and locational properties (e.g., stores, hotels, attractions). Results show that the prediction can be improved using GBR with a logarithmic transformation of the dependent variables. To investigate the quality of social media-based models by obtaining WiFi-based ground truth data, a microcontroller setup is developed to measure the actual number of people attending venues using WiFi presence detection, demonstrating that the similarity between the results of WiFi data collection and Google “Popular Times” is relatively promising.
Influence of Cultural Identity on Tourists’ Authenticity Perception, Tourist Satisfaction, and Traveler Loyalty
Authors: Tian Di , Wang Qiongyao , Law Rob , Zhang Mu
Published: August 2020

Intangible cultural heritage is a natural fit for tourism development due to its extensive cultural and artistic value. Authenticity is important in the development of intangible cultural heritage tourism. This case study considered Celadon Town, a classic scenic spot of intangible cultural heritage in Zhejiang Province, China, to design questionnaires and a research model involving cultural identity, authenticity perception, tourist satisfaction, and traveler loyalty. This model was used to explore the indigenous presentation of authenticity, that is, the “Traditional Firing Technique of Longquan Celadon,” and its impact on tourist satisfaction and loyalty. On the basis of the research model and hypotheses, relevant data were collected through a questionnaire survey, tested, and analyzed using a structural equation model (SEM). Findings indicate that authenticity of intangible cultural heritage has a significant positive effect on destination satisfaction and loyalty, which supplements related research on the authenticity of intangible cultural heritage destinations. This study advocates that building a characteristic town is a unique development mode of intangible cultural heritage tourism. The model integrates the cultural and tourism attributes of intangible cultural heritage. Based on this development model, the study offers related suggestions for the construction of authenticity and the realization of long-term development of tourism destinations.
Teacher Confidence in Professional Training: The Predictive Roles of Engagement and Burnout
Authors: Fiorilli Caterina , Buonomo Ilaria , Romano Luciano , Passiatore Ylenia , Iezzi Domenica Fioredistella , Santoro Paolo Emilio , Benevene Paula , Pepe Alessandro
Published: August 2020

Teachers’ work engagement positively impacts teachers’ attitudes towards their job. Nevertheless, teachers may experience burnout during their career, which negatively impacts their professional learning opportunities. In this study we investigated the relationship between teachers’ levels of burnout, work engagement, and their confidence in in-service training in a sample of Italian teachers. We expected that burnout mediated the relationship between work engagement and teachers’ confidence in training. A total of 481 teachers completed self-report questionnaires about engagement and burnout, with an ad hoc Confidence in Training Index developed to assess their attitudes towards professional development courses. The mediation analysis confirmed that the teachers’ levels of burnout mediated the relationship between their work engagement and their confidence in in-service training. Findings suggest that teacher confidence in policies about professional training should be evaluated by taking into account their level of engagement and burnout.
A Multidimensional Model for the Vernacular: Linking Disciplines and Connecting the Vernacular Landscape to Sustainability Challenges
Authors: Galan Juanjo , Bourgeau Felix , Pedroli Bas
Published: August 2020

After developing a systematic analysis of the vernacular phenomenon in different disciplines, this paper presents a flexible model to understand the multiple factors and the different degrees of vernacularity behind the many processes that lead to the generation of material culture. The conceptual model offers an open, polythetic and integrative approach to the vernacular by assuming that it operates in different dimensions (temporal, socio-political, sociological, locational, epistemological, procedural, economic and functional), and that the many attributes or characteristics included in those dimensions are all relevant but not strictly necessary. The model is intended to facilitate a more methodical and rigorous connection between the vernacular concept and contemporary discourses on sustainability, resilience, globalization, governance, and rural-urban development. In addition, and due to its transdisciplinary character, the model will enable the development of comparative studies within and between a wide range of fields (architecture, landscape studies, design, planning and geography). A prospective analysis of the use of the model in rural landscapes reveals its potential to mediate between the protective approach that has characterized official planning during the last decades and emergent approaches that advocate the reinterpretation of the vernacular as a new form to generate new collective identities and to reconnect people and place.
Educational Model for Evaluation of Airport NIS Security for Safe and Sustainable Air Transport
Authors: Kelemen Miroslav , Polishchuk Volodymyr , Gavurová Beáta , Andoga Rudolf , Szabo Stanislav , Yang Wenjiang , Christodoulakis John , Gera Martin , Kozuba Jaroslaw , Kaľavský Peter , Antoško Matej
Published: August 2020

One of the praxeological problems of safe and sustainable air transport (airfreight transport/air cargo, and air passenger transport) is the prevention and management of risks by competent staff, with the support of modern information and communication technologies. This paper presents an educational information model and software for the airport network and information systems risk assessment, primarily intended for aviation education and training of professionals for ensuring safe and sustainable air transport. The solution to the problem is based on the application of the fuzzy logic method in the air transport environment. Based on a fuzzy expert model, the selected scenario, and the input data established separately for airport assets by a group of 23 experts from aviation practice and a university, the following three assessments of airport network information system assets were constructed: Asset A2 (meteorological information systems) has an insignificant risk with an estimated 0.1162, and assets A1 (air traffic control and management (ATM), navigational aids and approach) and A3 (runway monitoring system) received a low risk of airport network and information systems (NIS) security with ratings of 0.2623 and 0.2915, respectively. An airport NIS risk assessment was aggregated (0.2288), indicating a low degree of security risk to the airport’s network and information systems. The aggregated risk assessment of airport NIS, including financial loss data, was calculated as 0.1438, representing a low degree of security risk to the airport’s network and information systems. Scenarios for evaluating airport assets are changing for students during education. The results of the developed model and its software will be part of the Simulation Center of the Faculty of Aeronautics.
Enhancement of Small Towns in Inland Areas. A Novel Indicators Dataset to Evaluate Sustainable Plans
Authors: Nesticò Antonio , Fiore Pierfrancesco , D’Andria Emanuela
Published: August 2020

In response to the abandonment and depopulation of small towns in inland areas, it is necessary to provide analysis and technical-economic evaluation tools with the aim of selecting effective recovery and valorization strategies. In the light of what criteria and indicators should this selection be carried out? The principles of sustainability guide us to a new definition of social, economic, environmental, and historical-architectural criteria. The intention is to outline a new way of classifying the judgment criteria, exclusively referring to the peculiarities of small towns. In turn, the criteria are specifically defined in sixteen sub-criteria, again able to represent the salient features of small municipalities: Local traditions, genius loci, urbanization levels, but also prevailing economy, environmental (flora and fauna, water, soil, air, etc.), and historical-architectural components (relations between the small town and the immediate context, formal relationship between building and urban core, etc.). This is followed by the drafting of a novel dataset of evaluation indicators, capable of expressing the project actions’ capacity to pursue the objectives expressed by the criteria. These are datasets that give back 24 indicators for the social sub-criteria, 42 for the economic sub-criteria, 34 for the environmental ones, and 38 for the historical-architectural ones. The goal-criteria-subcriteria-indicators structure outlined in this paper opens up research perspectives on the characterization of a hierarchical model of multi-criteria analysis.
Neighbourhood Social Resilience (NSR): Definition, Conceptualisation, and Measurement Scale Development
Authors: Larimian Taimaz , Sadeghi Arash , Palaiologou Garyfalia , Schmidt III Robert
Published: August 2020

The literature on social resilience lacks a precise definition of this concept and a clear guideline on how to measure it. Particularly, social resilience at the neighbourhood scale has received remarkably little scholarly attention. This study contributes toward filling these gaps in the literature by developing and empirically testing the neighbourhood social resilience (NSR) model as a robust and reliable measurement instrument that integrates various aspects of this complex concept into one coherent and fine-grained psychometric model. The reliability and validity of the NSR model are empirically tested using questionnaire data collected from 234 respondents in five neighbourhoods of Dunedin city, New Zealand. Furthermore, a more nuanced definition for neighbourhood social resilience is provided. Results indicate that social resilience is a second-order and multidimensional concept incorporating eight dimensions. Each of these dimensions captures a distinct piece in the jigsaw of social resilience; therefore, failure to incorporate all dimensions may provide an incomplete picture of this complex phenomenon. Our research bridges the gap between top-down approach of stakeholders and policymakers and bottom-up perceptions and expectations of residents about social resilience of their urban neighbourhood.
Assessing Sustainability in the Shipbuilding Supply Chain 4.0: A Systematic Review
Authors: Ramirez-Peña Magdalena , Abad Fraga Francisco J. , Salguero Jorge , Batista Moises
Published: August 2020

The supply chain is currently taking on a very important role in organizations seeking to improve the competitiveness and profitability of the company. Its transversal character mainly places it in an unbeatable position to achieve this role. This article, through a study of each of the key enabling technologies of Industry 4.0, aims to obtain a general overview of the current state of the art in shipbuilding adapted to these technologies. To do so, a systematic review of what the scientific community says is carried out, dividing each of the technologies into different categories. In addition, the global vision of countries interested in each of the enabling technologies is also studied. Both studies present a general vision to the companies of the concerns of the scientific community, thus encouraging research on the subject that is focused on the sustainability of the shipbuilding supply chain.
Does the ESG Index Affect Stock Return? Evidence from the Eurostoxx50
Authors: La Torre Mario , Mango Fabiomassimo , Cafaro Arturo , Leo Sabrina
Published: August 2020

Recent findings provide evidence that companies highly rated in terms of Environmental, Social, and Governance (ESG) score report higher excess returns and lower volatility, this being supported by the assumption that ESG factors are considered, by market agents, as a good proxy for firms’ financial soundness. The aim of this paper is to investigate how ESG components affect stock returns. We use a two-step methodology to analyze the performance of companies included in the Eurostoxx50 index over the 2010–2018 period according to their ESG score. To classify companies in terms of ESG commitments, we combine several ESG indicators (quantitative ratings, scorings and qualitative-opinions) collected on a monthly basis. Our results do not support previous evidence; the Eurostoxx50 companies’ performance does not seem to be affected by their efforts in terms of ESG commitments.
Science Education for Sustainability: Strengthening Children’s Science Engagement through Climate Change Learning and Action
Authors: Trott Carlie D. , Weinberg Andrea E.
Published: August 2020

Scientists and sustainability scholars continue to make urgent calls for rapid societal transformation to sustainability. Science education is a key venue for this transformation. In this manuscript, we argue that by positioning children as critical actors for sustainability in science education contexts, they may begin to reimagine what science means to them and to society. This multi-site, mixed-methods study examined how children’s climate change learning and action influenced their science engagement along cognitive, affective, and behavioral dimensions. For fifteen weeks, ten- to twelve-year-olds participated in an after-school program that combined on-site interactive educational activities (e.g., greenhouse gas tag) with off-site digital photography (i.e., photovoice process), and culminated in youth-led climate action in family and community settings. Participants were 55 children (M = 11.1 years), the majority from groups underrepresented in science (52.7% girls; 43.6% youth of color; 61.8% low-income). Combined survey and focus group analyses showed that, after the program, science became more relevant to children’s lives, and their attitudes towards science (i.e., in school, careers, and in society) improved significantly. Children explained that understanding the scientific and social dimensions of climate change expanded their views of science: Who does it, how, and why—that it is more than scientists inside laboratories. Perhaps most notably, the urgency of climate change solutions made science more interesting and important to children, and many reported greater confidence, participation, and achievement in school science. The vast majority of the children (88.5%) reported that the program helped them to like science more, and following the program, more than half (52.7%) aspired to a STEM career. Lastly, more than a third (37%) reported improved grades in school science, which many attributed to their program participation. Towards strengthening children’s science engagement, the importance of climate change learning and action—particularly place-based, participatory, and action-focused pedagogies—are discussed.
Consumer Willingness To Pay for Proenvironmental Attributes of Biogas Digestate-Based Potting Soil
Authors: Herbes Carsten , Dahlin Johannes , Kurz Peter
Published: August 2020

Biogas from anaerobic digestion has become an important element in the renewable energy portfolio of many countries. In anaerobic digestion, digestate is produced as a byproduct. This could be used to produce fertilizers and potting soils for home gardeners substituting mineral fertilizers or peat-based products. However, this depends on consumer willingness to pay (WTP) for such products, which we investigate in this study. To this end, we conducted a discrete choice experiment (DCE) with 507 private consumers. From the 6084 decisions made, we derived Bayesian part-worth utilities using a preference share model and so calculated the WTP for different proenvironmental attributes of potting-soil products. We also assessed the influence of proenvironmental attitudes on the WTP. We discovered five distinct consumer groups in our respondents. Some show a significant WTP for proenvironmental attributes such as “organic”, “peat free”, and “without guano”. Three descriptions of digestate as a “renewable resource”, a “fermentation residue”, or a “biogas residue” elicited three markedly different WTP responses across all classes, with “renewable resource” garnering the highest WTP and “biogas residue” the lowest. Consumers with a stronger proenvironmental attitude exhibited a higher WTP for proenvironmental attributes. Our results can help marketers of digestate-based potting soils discover suitable price points for their products and design differentiated pricing strategies across consumer groups.
A Comprehensive Evaluation on Types of Microcracks and Possible Effects on Power Degradation in Photovoltaic Solar Panels
Authors: Bdour Mathhar , Dalala Zakariya , Al-Addous Mohammad , Radaideh Ashraf , Al-Sadi Aseel
Published: August 2020

Photovoltaic (PV) panels installation has become one of the major technologies used for energy production worldwide. Knowledge and competitive prices are the main reasons for the spread usage and expanded exploiting of PV systems. Accordingly, this creates several challenges for manufacturers and customers, mainly, the quality of PV panels to withstand environmental conditions during service lifetime. Hence, the quality of PV panels is a vital aspect. By thinking of PV power plants, it appears that some factors should be considered, like the developing microcracks (µcracks). An issue like that increases the chances of having power loss during the operation phase. Notably, µcracks develop in different shapes and orientations; the variation depends on what causes them. This study is a presentation and summary of data collected from different projects in Jordan to describe the effect of each µcracks shape on power loss, aiming to give decision makers an indication to decide whether to replace the faulty panels or not, depending on their own conditions and projects sizes. Hence, in this study, it was found that the µcracks have impacted power loss differently and recorded power reduction of percentages of 0.82–3.21% for poly-crystalline technology. Variation in power degradation depends on the module situation; whether it is stocked in facility or operated on-site. In the mono-crystalline technology case, the power losses varied between 0.55% and 0.9%, with the exception of some samples from both technologies that have effects other than microcracks, which affected power severely. Furthermore, a general overview is provided for µcracks before installation.
Does Social Media Marketing and Brand Community Play the Role in Building a Sustainable Digital Business Strategy?
Authors: Ho Ching-Wei , Wang Yu-Bing
Published: August 2020

This study investigates the effects of customer relationships on a brand’s social network website (BSN) for virtual and physical retail channels in the digital business environment. The authors also further explore the sustainable customer relationships with virtual and physical retail channels (i.e., consumer–community identification, CCI; and consumer–retailer love, C-R Love) and customer attitudinal/behavioral loyalty toward a retailer (re-purchase and word of mouth, WOM). The authors develop a framework to describe and examine the connections among customer relationships for BSN, CCI, C-R Love, and user loyalty for a retailer. Furthermore, it tests the mediating effects of virtual (i.e., CCI) and physical (i.e., C-R Love) channels on the correlation between BSN relationships and customer loyalty. The model and hypotheses in this study employ structural equation modeling with survey data. The study shows that partial customer relationships in BSNs directly or indirectly influence CCI and C-R Love, and both CCI and C-R Love positively influence re-purchase intentions and WOM communications. This study contributes a unique model for a process by which the customer relationships in BSNs can affect a sustainable retail loyalty through the virtual/physical channels. This finding can be viewed as pioneering and as setting a benchmark for future research.
Trip Chaining Model with Classification and Optimization Parameters
Authors: Esztergár-Kiss Domokos
Published: August 2020

In order to model the complex requirements of users travelling in an urban environment, the relevant parameters for creating activity chains have to be identified. In this study, travel related parameters were collected and grouped into two main types: classification parameters and optimization parameters. In the case of optimization parameters, further grouping was performed where general and comfort parameters were introduced. Additionally, the possible values and data sources of the parameters were identified. A utility function was created to take into account the optimization parameters and the weights. Weights related to comfort optimization parameters were aggregated to decrease the number of required settings by the users. Finally, the features of the proposed optimization algorithm are described. With the identified parameters, aggregated weights and elaborated utility function activity chains can be optimized for users with different requirements.
Inequalities and the Impact of Job Insecurity on Health Indicators in the Spanish Workforce
Authors: Payá Castiblanque Raúl , Beneyto Calatayud Pere J.
Published: August 2020

In a context of high job insecurity resulting from social deregulation policies, this research aims to study health and substance abuse inequalities in the workplace from a gender perspective. To this end, a transversal study was carried out based on microdata from the National Health Survey in Spain—2017, selecting the active population and calculating the prevalence of the state of health and consumption, according to socio-occupational factors (work relationship, social occupational class, time and type of working day). Odds ratios adjusted by socio-demographic variables and their 90% confidence intervals were estimated by means of binary logistic regressions stratified by sex. The results obtained showed two differentiated patterns of health and consumption. On the one hand, unemployed people and those from more vulnerable social classes showed a higher prevalence of both chronic depression and anxiety and of hypnosedative and tobacco use. On the other hand, the better positioned social classes reported greater work stress and alcohol consumption. In addition, while unemployment affected men’s health more intensely, women were more affected by the type of working day. The study can be used to design sustainable preventive occupational health policies, which should at least aim at improving the quantity and quality of employment.
Study on the Deformation Mechanism of Reservoir Landslides Considering Rheological Properties of the Slip Zone Soil: A Case Study in the Three Gorges Reservoir Region
Authors: Li Chun , Tang Huiming , Wang Yankun
Published: August 2020

Reservoir water level fluctuation is one of the main extrinsic factors that could change the stress field in landslides, as well as the mechanical strength of geomaterials, hence affecting the deformation and stability of landslides. The largest reservoir landslide in the Three Gorges Reservoir area was selected for a case study. The impact of reservoir water level fluctuation is represented by the dynamic change in the underground seepage field and was thereby analyzed with numerical modeling. The deformation behavior considering the rheological properties of the slip zone soil was studied. The sudden change in the displacement–time curve was selected as the failure criterion for the investigated landslide. The evolution process of the accelerated deformation stage was divided into slow acceleration, fast acceleration, and rapid acceleration stages. The Huangtupo landslide is characterized by a retrogressive landslide and is currently in the creep deformation stage; the deformation mechanism and deformation characteristics are closely related to the reservoir water level fluctuation. Research was carried out by means of field investigation, in situ monitoring, and numerical simulation to provide a true and reliable result for stability evaluation.
Measurement of Permeability in Horizontal Direction of Open-Graded Friction Course with Rutting
Authors: Yoo Jaewon , Nguyen Tan Hung , Lee Eungu , Lee Yunje , Ahn Jaehun
Published: August 2020

Although the permeability of open-graded friction course (OGFC) materials in the transverse direction and the reduction in permeability associated with long-term traffic loading are important issues, they have remained under researched thus far. In this study, testing equipment and procedure were developed to evaluate the permeability of an OGFC specimen along the horizontal direction and its reduction due to rutting. Horizontal permeability tests were conducted by varying the hydraulic gradient of specimens with porosities of 19.6%, 15.6%, and 10.3%. The reduction in cross-section due to traffic loading was simulated via a wheel tracking test, and the permeability was subsequently evaluated. The reliability of test methodology was successfully verified; the tendency of the relationship between discharge velocity and hydraulic gradient was in good agreement with existing research results. The reduction in cross-sectional flow area due to rutting decreased and the horizontal permeability. The test results using developed testing equipment will enable efficient OGFC design.
Persistence in Self-Employment Rates before the Great Lockdown: The Case of the UK
Authors: Lopez-Perez Elisabeth , Rodriguez-Santiago Ana , Congregado Emilio
Published: August 2020

A growing body of empirical literature—both on the micro and macro scale—is devoted to exploring the existence of hysteresis—or at least persistence—in self-employment, i.e., whether policy, economic or external shocks have transitory or persistent effects on the probability of survival, and in turn, on the natural rate of self-employment. In aggregate time series studies, the usual method to address this issue has been to look for unit roots by using alternative tests or by using unobservable components models. In this research, we performed a battery of tests and competing approaches to check the robustness of our results with UK self-employment time series. The UK is a suitable case for study because the recent evolution of the UK self-employment rate figures shows a steady growth since the beginning of the millennium. This long-term rise in UK self-employment has attracted the attention of scholars, at least, before the Great Lockdown. We find evidence of hysteresis, while business cycle output variations significantly affect self-employment rates. The article discusses the implications of the findings.