bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Factors Influencing the Clinical Severity of Omicron and Delta Variants
Authors: Zhao Shanlu , Luo Kaiwei , Guo Yichao , Fang Mingli , Sun Qianlai , Dai Zhihui , Yang Hao , Zhan Zhifei , Hu Shixiong , Chen Tianmu , Li Xiaojun
Published: June 2023

The Omicron variant is the dominant strain circulating globally, and studies have shown that Omicron cases have milder symptoms than Delta cases. This study aimed to analyze the factors that affect the clinical severity of Omicron and Delta variants, evaluate and compare the effectiveness of COVID-19 vaccines with different technological platforms, and assess the vaccine effectiveness against different variants. We retrospectively collected the basic information of all local COVID-19 cases reported by Hunan Province to the National Notifiable Infectious Disease Reporting System from January 2021 to February 2023, including gender, age, clinical severity, and COVID-19 vaccination history. From 1 January 2021 to 28 February 2023, Hunan Province reported a total of 60,668 local COVID-19 cases, of which, 134 were infected with the Delta variant and 60,534 were infected with the Omicron variant. The results showed that infection with the Omicron variant (adjusted OR (aOR): 0.21, 95% CI: 0.14–0.31), getting vaccinated (booster immunization vs. unvaccinated aOR: 0.30, 95% CI: 0.23–0.39) and being female (aOR: 0.82, 95% CI: 0.79–0.85) were protective factors for pneumonia, while old age (≥60 years vs. <3 years aOR: 4.58, 95% CI: 3.36–6.22) was a risk factor for pneumonia. Being vaccinated (booster immunization vs. unvaccinated aOR: 0.11, 95% CI: 0.09–0.15) and female (aOR: 0.54, 95% CI: 0.50–0.59) were protective factors for severe cases, while older age (≥60 years vs. < 3 years aOR: 4.95, 95% CI: 1.83–13.39) was a risk factor for severe cases. The three types of vaccines had protective effects on both pneumonia and severe cases, and the protective effect on severe cases was better than that on pneumonia. The recombinant subunit vaccine booster immunization had the best protective effect on pneumonia and severe cases, with ORs of 0.29 (95% CI: 0.2–0.44) and 0.06 (95% CI: 0.02–0.17), respectively. The risk of pneumonia from Omicron variant infection was lower than that from Delta. Chinese-produced vaccines had protective effects on both pneumonia and severe cases, with recombinant subunit vaccines having the best protective effect on pneumonia and severe pneumonia cases. Booster immunization should be advocated in COVID-19 pandemic-related control and prevention policies, especially for the elderly, and booster immunization should be accelerated.
Strongyloides spp. and Cytomegalovirus Co-Infection in Patient Affected by Non-Hodgkin Lymphoma
Authors: Lupia Tommaso , Crisà Elena , Gaviraghi Alberto , Rizzello Barbara , Di Vincenzo Alessia , Carnevale-Schianca Fabrizio , Caravelli Daniela , Fizzotti Marco , Tolomeo Francesco , Vitolo Umberto , De Benedetto Ilaria , Shbaklo Nour , Cerutti Alessandro , Fenu Piero , Gregorc Vanesa , Corcione Silvia , Ghisetti Valeria , De Rosa Francesco Giuseppe
Published: June 2023

To our knowledge, we have described the first case of Strongyloides/Cytomegalovirus (CMV) concomitant infection that occurred in a European country. The patient was a 76-year-old woman affected by relapsed non-Hodgkin lymphoma who presented interstitial pneumonia with a rapidly progressive worsening of respiratory insufficiency, leading to cardiac dysfunction and consequent death. CMV reactivation is a common complication in immunocompromised patients, while hyperinfection/disseminated strongyloidiasis (HS/DS) is rare in low endemic regions, but has been widely described in Southeast Asia and American countries. HS and DS are two consequences of the failure of infection control by the immune system: HS is the uncontrolled replication of the parasite within the host and DS the spreading of the L3 larvae in organs other than the usual replication sites. Only a few cases of HS/CMV infection have been reported in the literature, and only in one patient with lymphoma as an underlying disease. The clinical manifestations of these two infections overlap, usually leading to a delayed diagnosis and a consequent poor outcome.
Proteomics Identified UDP-Glycosyltransferase Family Members as Pro-Viral Factors for Turnip Mosaic Virus Infection in Nicotiana benthamiana
Authors: Ding Kaida , Jia Zhaoxing , Rui Penghuan , Fang Xinxin , Zheng Hongying , Chen Jianping , Yan Fei , Wu Guanwei
Published: June 2023

Viruses encounter numerous host factors that facilitate or suppress viral infection. Although some host factors manipulated by viruses were uncovered, we have limited knowledge of the pathways hijacked to promote viral replication and activate host defense responses. Turnip mosaic virus (TuMV) is one of the most prevalent viral pathogens in many regions of the world. Here, we employed an isobaric tag for relative and absolute quantitation (iTRAQ)-based proteomics approach to characterize cellular protein changes in the early stages of infection of Nicotiana benthamiana by wild type and replication-defective TuMV. A total of 225 differentially accumulated proteins (DAPs) were identified (182 increased and 43 decreased). Bioinformatics analysis showed that a few biological pathways were associated with TuMV infection. Four upregulated DAPs belonging to uridine diphosphate-glycosyltransferase (UGT) family members were validated by their mRNA expression profiles and their effects on TuMV infection. NbUGT91C1 or NbUGT74F1 knockdown impaired TuMV replication and increased reactive oxygen species production, whereas overexpression of either promoted TuMV replication. Overall, this comparative proteomics analysis delineates the cellular protein changes during early TuMV infection and provides new insights into the role of UGTs in the context of plant viral infection.
Assessing the Movements, Habitat Use, and Site Fidelity of the Giant Freshwater Whipray (Urogymnus polylepis) with Acoustic Telemetry in the Maeklong River, Thailand
Authors: Haetrakul Thanida , Campbell Teresa , Daochai Chayanis , Keschumras Nitiwadee , Tantiveerakul Tanatporn , Hogan Zeb , Chansue Nantarika
Published: June 2023

We used acoustic telemetry to assess site fidelity, movement patterns, and habitat use within the lower Maeklong River, Thailand, by 22 giant freshwater whipray Urogymnus polylepis. This study is the first of its kind for this rare, endangered species, and it begins to fill critical information gaps about its ecology and life history. Study animals were tagged subcutaneously in the dorsal area with acoustic transmitters and tracked for 12 months using a fixed array of eight receivers. Receivers were positioned within an 18 rkm section of the Maeklong, starting approximately 4 rkm upstream from the mouth. We calculated individual residency indices, tracked longitudinal movements, and assessed annual and seasonal patterns of site use. We also investigated spatial use patterns, diel activity patterns, and relationships of temperature and site fidelity. We detected 86% of our tagged whiprays, 53% of which were detected for the majority of the study period. Whiprays exhibited high site fidelity across seasons. Individuals made long longitudinal movements within the site for much of the study period but seemed to remain closer to the estuary during the second half of the rainy season and early winter. All receivers had large numbers of detections, but upstream receivers were visited for longer time durations than downstream receivers. A receiver in the middle of the study area had the highest detection rate, but low detection durations, suggesting that this receiver is in a migration corridor. A mix of immature and mature males and females was present in the site throughout the study period, suggesting that this area is not exclusively a breeding or nursery site. However, the high site fidelity suggests that this is an important aggregation site for the species. Effective conservation measures may include conservation zones and a shrimp reintroduction program upstream, ensuring fish passage through the middle of the site, and regulating traffic and pollution downstream. We found acoustic telemetry to be an effective study method and encourage its use to improve understanding of the giant freshwater whipray.
State of the art of rational design of efficient mufflers
Authors: Munjal M.L. , Kumar K.M.
Published: June 2023

An efficient exhaust muffler needs to satisfy the rather conflicting requirements of adequate insertion loss (IL) with limited back pressure, weight, size and cost. The unmuffled exhaust noise of an internal combustion engine peaks at the engine firing frequency and the first few harmonics
thereof. Designing the muffler (a wide-band low pass acoustical filter) for such low frequencies is quite a challenge. Therefore, design of efficient mufflers has remained an art as well as science. During the last two decades or so, however, (a) multi-hole cross-flow perforates, (b) multiply
connected perforated pipes and baffles, and (c) the double-tuned, grazing-flow concentric tube resonators have emerged as promising constituent elements. In this paper, elements (a) and (c) have been combined ingeniously to synthesize efficient muffler configuration for diesel generator (DG)
sets as well as automotive engines. Relatively simpler lumped parameter approximation for perforates opening into cavities, electro-acoustic analogies, and the simple expansion chamber equivalence of the double-tuned concentric tube resonator have been used to develop a rational design methodology.
A novel feature of this methodology is incorporation of the given back-pressure limit into the acoustic design process. The resulting muffler configurations are robust and can be scaled up (and down) easily for IL as well as back pressure.
Development of an empirical model for the prediction of the noise reduction coefficient for thin and low-density fibrous materials
Authors: Dunne Regan , Desai Dawood , Heyns Stephan
Published: June 2023

This paper presents the development of an empirical noise reduction coefficient model for the prediction of low-density, less than 50 kg/m3, thin, less than 20 mm thick, fibrous materials using multiple linear regression. The purpose of this empirical model is to assist design engineers,
working with thin and low-density materials, efficiently and effectively select the most appropriate material for the design. Therefore, several models were developed using software such as Statistical Analysis System. Thereafter, the models were compared using an internal and external data
set. A selection metric was developed to assist in the objective selection of the best model. It was found that the log model performed the best overall and thus was selected as the model of choice.
conceito de Estado Islâmico de acordo com quatro ideólogos de islamismo de século XX
Authors: J. K. Bonate Liazzat
Published: June 2023

Este artigo examina quatro teorias de Estado Islâmico elaboradas por ideólogos de islamismo do século XX, três dos quais sendo sunitas, Abū al-Aʿlā Mawdūdī (1903-1979), Fazlur Raḥmān, (1919-1988), Ḥasan al-Turābī (1932-2016), e um xiita, o āyatollāh Sayyid Rūhollāh Mūsawī Khomeinī (1902-1989). O artigo analisa como esses autores articulam o conceito de Estado Islâmico, como definem esse tipo de Estado e as suas características e qual o papel atribuem ao público muçulmano e à liderança religiosa nesse tipo de Estado.
Étude pétroarchéologique d’une série de silex du site des Baigneurs, à Charavines (Isère, France)
Authors: Fernandes Paul , Tallet Pascal
Published: June 2023

Dans le cadre de cette mission nous avons eu l’occasion de reprendre l’étude pétroarchéologique d’une partie du mobilier lithique du site sub-lacustre des Baigneurs, à Charavines (Isère). Une diagnose pétroarchéologique intégrant l’évolution naturelle des objets lithiques a permis d’esquisser les limites du domaine minéral exploité et donner un aperçu des échanges avec les autres régions. L’analyse des 169 objets confiés par le Musée Dauphinois (Grenoble) a été réalisée au printemps 2017. Cette série correspond à une sélection pétrographique réalisée à l’échelle macroscopique par M. Remicourt en juin 2016. La prestation a permis de déterminer la provenance de la majorité des objets. Ces derniers ont été comparés à la variabilité des échantillons géologiques présents dans les lithothèques : de Villard-de-Lans (collection Dolomieu), de l’association Archéo-Logis à Laussonne, du musée d’Orgnac et du CEPAM à Nice. Ce travail, fondé sur un comparatif robuste, a permis de discriminer 24 microfaciès correspondants à autant de gîtes. Ce résultat indique des comportements mêlant un approvisionnement principalement local, des collectes à l’échelle régionale, ainsi que des déplacements ou des échanges sur des distances bien plus importantes. Concernant ce dernier type de comportement, on note la présence de silex tourangeaux, de silex bédouliens en provenance des environs du Mont Ventoux et probablement des silex du nord de l’Italie type Maïolica.
Pré Peyret 1 (Gresse-en-Vercors, Isère, 1 620 m). Une station mésolithique de montagne
Authors: Picavet Régis , Angelin Alexandre
Published: June 2023

Located on the “ Hauts plateaux”, a large area selected as a natural reserve in the center of the “ Parc naturel régional du Vercors”, the “ Pré Peyret 1 and 2” mesolithic settlements have been discovered in 1998 by Regis Picavet and Sébastien Bernard-Guelle, during an archeological survey sponsored by the natural Park. During the year 1999, several survey tests were realized, revealing us an important mesolithic occupation. During the years 2007-2008, two archeological excavation campaigns have been organized at the “ Pré Peyret 1” settlement, located on a tiny hill, directed by Régis Picavet. Twenty square meters have been excavated and the numerous lithic artifacts have been assigned to the first and second Mesolithic cultures. These conditions allow

a palethnographic approach, which yet remains incomplete. The “ Pré Peyret 1” settlements belong to a large series of human occupations in altitude already known on the “ Hauts Plateaux” area and more generally in the alpine world, participating at a seasonal system of mountain attendance. Interrelations may be founded with the “ Grande Rivoire” (580 m asl.), mesolithic settlements giving us lots of cultural and archeobiological informations which are missing in open air sites.
Physical activity and sports science in Italian scientific research products
Authors: D'Elia Francesca , D'Isanto Tiziana , Esposito Giovanni , Altavilla Gaetano , Raiola Gaetano
Published: June 2023

Purpose. This study aims to measure the number of scientific production of Italian researchers, as framed on academic disciplines of Physical training and methodology (code M-EDF/01) and Sports science and methodology (code M-EDF/02), afferents to the academic recruitment field of Exercise and sports science (code 06/N2) and Didactics, special education and educational research (code 11/D2).

Material and Methods. The sample consisted of the entire population of full professors (n=30) belonging to the two academic disciplines of Physical training and methodology and Sports science and methodology, plus a proportional representation of the two academic recruitment fields with at least one associate professor per university, for a total of 124 researchers. The titles of the first ten scientific products in terms of more citations from the Google Scholar database were analysed for each researcher. The full consistency of the title with the scientific statement of the two academic disciplines was assessed, identifying the number of articles afferent to sports and physical activity, biomedical and Psycho-pedagogical domains. One-way ANOVA was used to compare the two academic disciplines of the two academic recruitment fields with the three domains.

Results. The aggregate data showed a prevalence of the biomedical domain over the sport and physical activity ones in both the academic disciplines, in the academic recruitment field of Exercise and sports science. On the other hand, in the academic recruitment of Didactics, special education and educational research, there was a prevalence of the sport and physical activity domain over the biomedical ones. In addition, modest Psycho-pedagogical and biomedical scientific production were found in the academic recruitment fields of Exercise and sports science and Didactics, special education and educational research, respectively.  

Conclusions. The problem of the different coherence of the scientific profiles of the researchers concerning the relevant academic recruitment field and possibly also to the two academic disciplines was confirmed.
The effect of circuit training, fartlek, and small-sided games on maximum oxygen consumption capacity building in futsal players
Authors: Fitrian Zanzabil Adwa , Graha Ali Satia , Nasrulloh Ahmad , Munir Ali , Асмара Мірза , Irsyad Naufallathuf Yaquttul
Published: June 2023

Purpose : This research aims to assess the effect of circuit training, fartlek, and small-sided games on futsal players' maximum oxygen consumption capacity.
Material and methods. This research was carried out at the Upik Indoor Futsal Banjarmasin field from May to June. The treatment consists of 16 meetings held three times a week. This research applies a random pre- and post-test control group design. Players from the FFC BSM Junior Futsal Club make up the population.
The results. As a result of the employment of sampling formulas and inclusion and exclusion criteria, forty individuals were included in this study. The adopted instrument is a multistage fitness test with a validity of 0.408 and reliability of 0.875. Data analysis using the help of SPSS includes normality, homogeneity, and hypothesis tests. The findings of this study's normality test indicated that the mean of each group achieved a significance level of > 0.05. Therefore it can be assumed that the data were normally distributed. Meanwhile, the homogeneity test results got a significance value of > 0.05, which can be considered homogeneous or the same data. This study showed that the three training groups showed a significant increase in the maximum oxygen consumption capacity of futsal players by obtaining a significance value of < 0.05. In contrast, the control group got a significance value of > 0.197, and It can be concluded that there was no significant influence. The study also showed that small-sided game training groups improved better than circuit training groups, fartlek groups, and control groups. The increase obtained from the small-sided games group, judging from the average difference value of the small-sided games training group, increased by 4.11, the circuit training group increased by 3.71, the fartlek group increased by 3.78, and the control group increased by 0.48.
Conclusion. Thus, it can be concluded that circuit training, fartlek, and small-sided games positively impact the improvement maximum oxygen consumption capacity in futsal players. However, the small-sided game training methods group found the greatest improvement in training methods in this study.
The use of the computer assisted rehabilitation environment in assessment and rehabilitation
Authors: Abdelmegeed Mohamed , Elkhawaga Hosny
Published: June 2023

Purpose. The purpose of this review article was to review and analyze the available literature regarding one of the most advanced virtual reality technologies. We reviewed and analyzed the use of the computer-assisted rehabilitation environment system in assessment and rehabilitation.

Materials and methods. PubMed, Web of Science, Cochrane Library, Scopus, and Physiotherapy Evidence Database databases were searched from inception to October 2021. We used the search term “Computer Assisted Rehabilitation Environment” and included articles which directly or indirectly addressed the use of the computer assisted rehabilitation environment system in assessment, rehabilitation and on healthy people. We excluded articles not published in the English language, conference proceedings, reports of abstracts only, and duplicated articles. Also, articles addressing the use of other virtual reality technologies whether they used fully immersive, semi-immersive, or non-immersive interfaces or virtual reality devices such as the Wii or Xbox gaming technologies were also excluded. The relevant studies were collected and critically analyzed.

Results. Our search retrieved 205 articles, with 119 duplicates identified and removed. Following screening 86 articles, we included 50 relevant articles which directly or indirectly addressed the computer-assisted rehabilitation environment system and were published in scientific journals. Twenty-two articles used the computer assisted rehabilitation environment for biomechanical analysis, 15 articles used the computer assisted rehabilitation environment for rehabilitation, 4 articles were reviews, and 9 articles addressed the computer assisted rehabilitation environment in other ways.

Conclusion. The computer assisted rehabilitation environment system is a promising tool for assessment and rehabilitation. It can be used with different concepts to assist in diagnosis and treatment, can be used for healthy individuals and with patients, and basically follows biomechanical principles in operating. The high cost and complex infrastructure, however, may be the restriction to its use for research purposes and in clinical practice.
Recurrent cardiac hydatid cysts with pericardial protrusion; a rare case presentation of Echinococcus granulosus
Authors: Beheshti Monfared Mahmoud , Ghaderi Hamid , Ansari Aval Zahra , Hekmat Manouchehr , Mirjafari Seyedeh Adeleh , Beheshti Monfared Reza , Tirdad Roshanak
Published: June 2023

Hydatid cyst (HC) is a rare pathology mostly found in less developed, livestock-raising countries. HC can be found anywhere in the body, however it is a rare finding in the heart, and its recurrence in the heart and pericardium is very rare. A 54-year-old woman who had undergone surgery for the removal of HC in another country 11 years before presented with shortness of breath and heaviness in the chest. The examinations and computerized tomography (CT) scan revealed a large mass measuring 60×50 mm in the pericardium cavity originating from the right atrial wall. Infection with Echinococcus granulosus was confirmed with serological enzyme-linked immunosorbent assay (ELISA) test and the patient underwent cardiac surgery. The patient underwent cardiopulmonary bypass, nevertheless did not suffer cardiac arrest, and aortic cross-clamping was not performed for her. The removed mass was filled with daughter cysts. The endocysts were removed and intramural cysts were drained. Following the surgery, the patient received treatment with albendazole for six months. Cardiac hydatid cyst recurrence is a rare but possible incident, and annual follow-ups and echocardiography are recommended.
Relationship between placental thickness, grading, and heterogeneity in fetal growth restriction in the third trimester of pregnancy by ultrasonography and pathology tests and their relationship with estimated fetal weight and neonatal outcome
Authors: Farahbod Farinaz , Zarean Elahe , Khanjani Somayeh , Moezzi Masoumeh , Mohammadizadeh Fereshteh , Shabanian Sheida
Published: June 2023

Introduction: The placenta is the influencing factor on the fetal weight and is as the first organ that reveals the pathological changes of pregnancy. Therefore, placental ultrasound findings influence the diagnosis of fetal growth restriction (FGR). Objectives: This study examines the relationship between placental thickness, grading and heterogeneity during ultrasound and placental pathology in third trimester FGR fetuses and its effect on neonatal outcome. Patients and Methods: This prospective observational study included 67 pregnant women with FGR fetuses in the third trimester of pregnancy with the mean gestational age of 34.52 ± 2.65 weeks and possible termination of pregnancy within the next seven days. The placental thickness, grading, and heterogeneity in ultrasonography were examined and compared with thickness and grading. Their effect was also considered in neonatal outcome and the results were analyzed. Results: In this study, there is a significant relationship between the thickness of the placenta before and after birth with the weight of the placenta, weight and Apgar score, neonatal arterial pH at birth and fetal growth restriction grading in ultrasound, and neonatal outcome. Conclusion: This study shows that ultrasonic placental findings can be effective in determining the final weight of the placenta and fetus and also the final outcome of the baby at birth. Therefore, ultrasound of the placenta should be performed along with pregnancy ultrasound.
Neurological complications as the hallmark symptoms of thrombotic thrombocytopenic purpura in sickle cell disease
Authors: Bahadoram Mohammad , Keikhaei Bijan , Rafie Shahram , Akade Esma'il , Nameh Goshay Fard Najmeh , Moghaddar Roozbeh
Published: June 2023

Thrombotic thrombocytopenic purpura (TTP) is a type of microangiopathy, which is characterized by the formation of small blood clots in the vessels, leading to organ damage and low platelet count. In sickle cell disease (SCD), TTP can occur due to the activation of the coagulation system and damage to the endothelial cells lining the blood vessels. The importance of TTP in SCD lies in its potential to cause severe and life-threatening complications, including stroke, renal and heart failure. Early recognition and treatment of TTP in SCD are crucial to prevent these complications and improve outcomes. In this letter, we highlighted the significance of neurological complications in the diagnosis of TTP in SCD.
Evaluation of effects of glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors on estimated glomerular filtration rate, albuminuria and weight in diabetic kidney disease: A prospective cohort study
Authors: Aledan Hayder , Jabar Saadi Sattar , Rasheed Jawad
Published: June 2023

Introduction: Albuminuria and baseline estimated glomerular filtration rate (eGFR) are the main predictors for progression of diabetic kidney disease (DKD). Objectives: The objectives of the study were to assess the effects of GLP1-RA (glucagon-like peptide-1 receptor agonists) and SGLT2i inhibitors therapy on estimated GFR, albuminuria, and weight in patients with DKD stage 3 and 4. Patients and Methods: This was a prospective cohort study of patients with stage 3 and 4 DKD over 6 months at Basra teaching hospital from November 1, 2020, to May 1, 2020. Baseline weight, UACR (urine albumin creatinine ratio), and eGFR were measured, and 6-months values were assessed between and within the group. Results: The baseline characteristics for the GLP-1 RA (GLP-1 receptor agonists) versus SGLT2i (sodium-glucose co-transporter-2 inhibitors) groups were mean ages 65 years versus 62.5 years, male (54.5% versus 50%), median weight (75 versus 80 kg), median eGFR (23.5 versus 39 ml/min/1.73 m2 ) and median UACR (925 mg/g versus 327 mg/g). In the GLP-1 RA group, after 6-months of therapy, there was 32% increase in eGFR (P<0.001), 29% decrease in UACR (P<0.001) and 4.5% decrease in weight while in the SGLT2i group, there was 4.5% decrease in eGFR (P=0.345), 34% decrease in UACR (P<0.001) and 2.8% decrease in weight (P=0.005). With cox-regression analysis, the HR for eGFR decline with SGLT2i therapy was 3.25 (95% CI: 1.1-9.97; P=0.039). Conclusion: GLP-1 RA, compared to SGLT2i therapy, caused an increase in eGFR in stages 3 and 4 CKD and caused more weight reduction but slightly less albuminuria reduction.
Study of plasma neutrophil gelatinase-associated lipocalin as an early marker of acute kidney injury following contrast agents
Authors: Ghodrati Samad , Mirrajei Seyedeh Masoomeh , Parsamanesh Negin , Kamali Koorosh , Esmaeilzadeh Abdolreza , Pezeshgi Aiyoub
Published: June 2023

Introduction: Acute kidney injury (AKI) is a common illness among hospitalized patients, which increases mortality and morbidity rate. Creatinine and neutrophil gelatinase-associated lipocalin (NGAL) are the most commonly conducted biomarkers of AKI. Objectives: The aim of current study was to assess NGAL as an early biomarker for AKI diagnosis following contrast agents. Patients and Methods: To follow the aim of the present case-control research, 165 individuals were entered the study; 80 patients were selected from Valiasr hospital of Zanjan city, and 85 healthy individuals were enrolled voluntarily. There were not any significant differences in sex distribution among healthy subjects. Plasma NGAL and creatinine were measured immediately before and at 12 and 72 hours post-contrast agents’ exposure. Results: There were 89 males and 76 females in the study groups. The mean age was 61.3 ± 18.2 years and 62.1 ± 17.2 years in the intervention and healthy groups, respectively. The mean of serum creatinine and NGAL level were 1.0± 0.2 mg/dL and 63.6 ±23.6 ng/mL in the control and 0.92 ± 0.23 mg/dL and 110 ± 82.3 ng/mL in the case group, respectively. There were remarkable different between serum NGAL and creatinine in the both groups. The NGAL level in the healthy and the patient group were 63.6 ± 23.6 ng/mL and 100.1 ± 121.7 ng/mL, respectively, which was considerably different between the case and control groups (P=0.01). The highest level of specificity and sensitivity were 86 and 55.5; they could be the main appropriate options for defining cut off. Conclusion: The findings showed, that NGAL level is an extremely specific and sensitive indicator for AKI diagnosis after 72 hours. Hence, this approach can open a novel insight into the AKI therapies.
KİŞİSEL VERİLERİN KİŞİLİĞİN BAŞLANGICI VE SONU ÖTESİNDE KORUNMASI
Authors: BADUR Emel
Published: June 2023

6698 sayılı Kişisel Verilerin Korunması Kanunu’nda (KVKK) kişisel veri, kimliği belirli veya belirlenebilir gerçek kişiye ilişkin her türlü bilgiyi kapsayacak genişlikte tanımlanmış ve koruma altına alınmıştır. Aynı Kanun çerçevesinde, “İlgili kişi” terimi de kişisel verisi işlenen gerçek kişiyi ifade edecek şekilde kullanılmıştır. Türk Medeni Kanunu’nun (TMK) 28/1. maddesi gereğince gerçek kişilerin kişiliği, sağ ve tam olarak doğmakla başlar ve kişinin ölümüyle sona erer. Açıklanan düzenlemeler ışığında, kişisel verilerin korunmasına ilişkin zamansal sınırın da -kural olarak- doğumla ölüm arasını kapsadığını söylemek yanlış olmayacaktır. Bununla birlikte bu çıkarımın istisnasız uygulanması, gerçek kişilerin doğum öncesinde kazandıkları bazı özelliklerin (genetik veriler gibi) sağ ve tam doğum öncesinde kişisel verilere ilişkin korumadan yararlanmasını engelleyecektir. İlgili kişinin ölümünden sonra, kişisel verilerinin korumasız kalmasıyla ortaya çıkacak hukuki sorunların önüne geçilmesi ihtiyacı Kişisel Sağlık Verileri Hakkında Yönetmelik’te dikkate alınmıştır. Yönetmeliğin 11. maddesinde “Ölenin sağlık verilerine erişim” kenar başlığı altında ölen bir kişinin kişisel sağlık verilerine erişilebilmesi ve bu verilerin saklanması hakkında özel bir düzenleme getirilmiştir. Bu makalenin amacı, kişisel verilerin doğum öncesinde (prenatal) ve ölüm sonrasında (post mortal) korunmasına yönelik gereksinime ilişkin çözüm yollarının araştırılmasıdır.
Simulasi Harga Opsi Call Asia Dengan Suku Bunga Tidak Konstan
Authors: Kamila Isti , Andriyati Ani
Published: June 2023

In the financial world, the thing that is interesting for investors today is to predict a reasonable Asian Call Option price that does not cause the seller or buyer of the option to experience losses. The constant interest assumption is more often used by previous research as an assumption in predicting the price of Asian Call Options. This is not in line with the fact that interest rate movements are not constant. The use of incorrect assumptions will affect the accuracy of prediction results. In overcoming this problem, this study aims to predict the price of Asian Call Options with non-constant interest rates using Monte Carlo simulation. The non-constant interest rate model used is Cox-Ingersoll-Ross (CIR) because this model produces positive interest rates. This study begins with a screening of Normally distributed interest rate data. The data is used to determine the parameters of the CIR interest rate model. Next, an Asian Call Option price simulation with non-constant interest rates was carried out and ended by analyzing a graph of the Asian Call Option price simulation results with non-constant interest rates.  The simulated price result of the Asian Call Option with non-constant interest rates converged at the value of $170.82. Based on the price chart of Asian Call Options with different strike prices, the larger the strike price causes, the larger the Asian Call Option price, which corresponds to the price characteristics of the Asian Call Option. In addition, by extending the maturity period, the price of Asian Call Options with non-constant interest rates is greater according to the price characteristics of Asian Call Options.
СУЧАСНІ УЯВЛЕННЯ ПРО РОЛЬ БІОПЛІВКИ У ВИНИКНЕННІ ПАТОЛОГІЇ ТВЕРДИХ ТКАНИН ЗУБІВ
Authors: Заболотна І.І.
Published: June 2023

Мета дослідження. Узагальнення сучасної наукової інформації, що стосується ролі біоплівки в етіопатогенезі патології твердих тканин зубів. Методи дослідження. Були проаналізовані україномовні та англомовні публікації за останні десять років, які розглядали питання взаємодії дентальної біоплівки, ротової рідини і твердих тканин у появі захворювань зубів. Наукова новизна. В обзорі представлені сучасні уявлення про існування мікроорганізмів на поверхні зубів у вигляді над`ясенної біоплівки. Експериментально доведено, що у стані стабільної біоплівки вони викликають хронічні форми захворювань. При цьому ацидофільні бактерії приймають безпосередню участь у появі осередку каріозного ураження. Проведений аналіз показав, що мікрофлора порожнини рота являється етіологічним фактором, але не завжди достатнім для розвитку патології. Слина виступає в якості захисного фактору не тільки під час дії демінералізуючих агентів, пов`язаних зі складом дентальної біоплівки. Вона є важливим фактором у патогенезі некаріозних цервікальних уражень зубів, коли хімічна демінералізація твердих тканин викликана атакою дієтичної кислоти. Звертається увага на сучасні тенденції у розробці пломбувальних матеріалів для відновлення дефектів зубів, які б володіли антимікробними властивостями для подовження терміну служби реставрацій, особливо у цервікальній ділянці. Але якість відновлень дефектів зубів залежить не тільки від використаного пломбувального матеріалу, але і від індивідуальних особливостей пацієнта, таких як гігієна порожнини рота, низьковуглеводна дієта, буферна ємкість слини. Висновки. Аналіз сучасних наукових джерел показав, що біоплівка приймає безпосередню участь в етіопатогенезі патології твердих тканин зубів. При цьому ротова рідина виступає захисним фактором. Контроль за формуванням дентальної біоплівки дозволить прогнозувати перебіг уражень зубів, своєчасно вжити профілактичні заходи, що сприятиме зменшенню поширеності та інтенсивності стоматологічної патології.
КОРЕКЦІЯ БІОХІМІЧНИХ ПОКАЗНИКІВ КІСТКОВОЇ ТКАНИНИ ПАРОДОНТУ ЩУРІВ ПРИ ЕКСПЕРИМЕНТАЛЬНОМУ МОДЕЛЮВАННІ ПАРОДОНТИТУ НА ТЛІ ОРТОДОНТИЧНОГО ПЕРЕМІЩЕННЯ ЗУБІВ
Authors: Адамів С.С. , Макаренко О.А.
Published: June 2023

Зубощелепні аномалії відносяться до основних стоматологічних захворювань і характеризуються високою поширеністю. Таким чином, планування лікувально-профілактичних заходів, розробка або удосконалення існуючих методів терапії гінгівіту у підлітків є невід’ємною частиною ефективного лікування зубощелепних аномалій у них за допомогою незнімнних ортодонтичних конструкцій. Тому проведення експериментальних досліджень розробленого лікувально-профілактичного комплексу є актуальним завданням сучасної стоматології. Мета дослідження. Експериментальна оцінка на щурах, на тлі моделі перекисного пародонтиту та ортодонтичного переміщення зубів, змін біохімічних показників кісткової тканини пародонту під дією розроблених лікувально-профілактичних заходів. Матеріали і методи дослідження. В експериментальній роботі використовували наступні препарати «Спіруліна, екстракт» (Примафлора, Україна) і «Кальцікер» (Індоко Ремедіс Лімітед, Індія). На основі Спіруліни готували мукозоадгезивний гель для порожнини рота. Досліди були проведені на 25 білих щурах лінії Вістар (самці, 5 місяців, маса 325 ± 18 г), яких поділили на 4 групи. Результати та обговорення. В кістковій тканині пародонту щурів з модельованою патологією порушуються процеси мінералізації з переважанням активності деструктивних ферментів, спостерігається зниження білка и кальцію. Профілактичне застосування запропонованих препаратів на фоні модельованого перекисного пародонтиту з додатковим ортодонтичним переміщенням зубів надавало коригуючу дію на зміни в кістковій тканині. Найбільш ефективні результати спостерігалися після використання комплексної профілактики. В кістковій тканині щелеп щурів комплекс виявляв властивості знижувати деструктивні процеси як мінеральної та і органічної частини кісткової тканини пародонту щурів, а також стимулював процеси її мінералізації в пародонтогенних умовах та ортодонтичного втручання.
МОДИФІКОВАНИЙ МЕТОД ЛІКУВАННЯ СКУПЧЕНОСТІ ЗУБІВ У ЗМІННОМУ ПРИКУСІ
Authors: Кримовський К.Г. , Канюра О.А.
Published: June 2023

Мета дослідження. Розробка раціонального протоколу лікування пацієнтів зі скупченістю зубів у змінному періоді відповідно до типів росту лицевого скелета, а також проведення порівняльного аналізу ефективності лікування за традиційним та запропонованим протоколами. Методи дослідження. Пацієнти зі скупченістю зубів у змінному прикусі (n=164) були обстежені протягом останніх трьох років на базі стоматологічного медичного центру НМУ імені О.О. Богомольця, Київ. Загалом було проаналізовано 328 КЛКТ зрізів лицевого скелета (середнє поле зору) до та після лікування. Наукова новизна. На сучасному етапі інтерес представляє ефективність нового підходу до ортодонтичного лікування скупченості зубів в змінному прикусі в залежності від наявного типу росту лицевого черепа. Висновки. Результати, отримані через 16 місяців у пацієнтів з горизонтальним типом росту, свідчать про те, що значення ефективності лікування пацієнтів ІІ клінічної групи становило 58,1±1,3%; через 17 місяців у пацієнтів з вертикальним і нейтральним характером росту значення ефективності лікування клінічної групи ІІІ становило 66,7±1,6%, клінічної групи І – 52,3±0,9%. Результати свідчать про підвищення ефективності лікування даної патології та значне скорочення термінів лікування. Запропонований нами алгоритм дозволяє скоротити тривалість лікування на 3-4 місяці.
La narrativa digital de los especiales multimedia. Análisis de los condicionantes de producción y los procesos de transformación de los modos de narrar en el ciberperiodismo colombiano
Authors:   , Bejarano Barragán Johanna Paola
Published: June 2023

La tesis analiza los condicionantes de producción y la configuración discursiva de las narrativas digitales, para comprender las transformaciones en los modos de narrar el conflicto armado colombiano a través de especiales multimedia en los medios digitales colombianos ElTiempo.com, Semana.com y Verdadabierta.com (2012-2015). El análisis explora la aplicación del concepto de convergencia y la integración de medios, así como las rutinas y modelos de producción de especiales multimedia durante el periodo de negociaciones entre el Gobierno colombiano y las Fuerzas Armadas Revolucionarias de Colombia (FARC), (2012-2016). En su desarrollo la tesis propone una matriz de análisis narratológico desde donde identifica las dimensiones de la historia y el relato (lo que se cuenta y como se cuenta) y las narrativas líneas predominantes en la construcción de las historias (relatos rememorativos, relatos analíticos, relatos de travesía y relatos de seguimiento o reconstrucción histórica). También presenta una propuesta de determinantes de los niveles de convergencia e integración en los planos del contenido y los equipos de producción periodística multimedia en los medios mencionados.
TÜRKİYE’DE İKİDİLLİLİK ÜZERİNE YAPILMIŞ AKADEMİK ÇALIŞMALARIN EĞİLİMLERİ
Authors: CAN Furkan , KARDAŞ Mehmet Nuri
Published: June 2023

Çalışmanın amacı Türkiye’de iki dillilik üzerine yapılmış akademik çalışmaların (tez ve makale) eğilimlerini belirlemektir. Çalışma nitel araştırma yöntemine uygun olarak hazırlanmıştır. Çalışmanın verilerini incelemek ve araştırmanın problem sorularına yanıt aramak üzere nitel araştırma tekniklerinden doküman taraması/incelemesi yapılmıştır. Çalışmanın verilerinin incelenmesi sürecinde veri toplama aracı olarak araştırmacılar tarafından geliştirilen Akademik Eser İnceleme Formu kullanılmıştır. Çalışmanın materyalini Türkiye’de iki dillilik üzerine yayımlanan ve tam metnine ulaşılan lisansüstü tez ve araştırma makaleleri oluşturmuştur. Veri toplama aracı ile toplanan verilerin analizinde nitel analiz tekniklerinden betimsel analiz yapılmıştır. Çalışmanın sonunda 1923-2021’de toplamda 23’ü doktora tezi, 98’i yüksek lisans tezi, 149’u makale olmak üzere 270 adet çalışma yapıldığı; yıllara göre çalışma sayısında düzenli bir artışın olduğu belirlenmiştir. Lisansüstü tezlerin %89’unun Sosyal Bilimler ve Eğitim Bilimleri enstitülerinde yapıldığı, sadece 41 üniversitede ilgili konuda tez yapıldığı, en çok tezin yapıldığı ilk beş üniversitenin sırasıyla Gazi Üniversitesi, Hacettepe Üniversitesi, Çukurova Üniversitesi, İstanbul Üniversitesi, Ankara Üniversitesi olduğu tespit edilmiştir. İncelenen çalışmaların %67’sinde nitel, %29’unda nicel, %4’ünde ise karma araştırma yönteminin kullanıldığı belirlenmiştir. Çalışmalarda araştırma konusu edilen dil becerilerinin sırasıyla yazma becerisi %18,1, konuşma becerisi %12,5, okuma becerisi %5,5 ve dinleme becerisi %1,4 oranında çalışıldığı, çalışmaların %60,7’sinde ise karma dil becerileri ve diğer konularda yapıldığı sonucuna ulaşılmıştır. Yapılan çalışmaların çalışma gruplarını/materyalini sırasıyla öğrenciler %49, dokümanlar %21, yetişkin iki dilliler %15, öğretmenler %9, veliler %4, akademisyenler %2 oluşturduğu belirlenmiştir.
GENDER DALAM PERSPEKTIF PENDIDIKAN ISLAM
Authors: Farhan Fachmi
Published: June 2023

Penelitaian ini bertujuan untuk mengetahui peran gender dalam perspektif Islam terutama dalam pendididikan. Masih  banyak  yang beranggapan  membedakan peran dan kedudukan laki-laki dan perempuan. Faktor penyebab pembedaan kedudukan ini diantaranya adanya kesalahan pemahaman dalam mengkonstruksi peran sosial antara laki-laki dan perempuan sebagai akibat dari interpretasi teks suci al- Qur’an secara particular dn terkesan tidak utuh. Hal ini tentu mengakibatkan terjadinya konsepsi-konsepsi yang tidak seimbang dalam menempatkan posisi laki-laki dan perempuan dalam kehidupan masyarakat. Penelitian  ini dilakukan dengan metode desripsi kualitatif, dengan pendekatan kepustakaan atau library research. Hasil dari penelitian ini Islam selalu menempatkan semua hal pada posisi yang se- imbang. Islam juga menempatkan Laki-laki dan perempuan sebagai manusia yang memiliki posisi seimbang dan sama.  meletakkan kedudukan laki-laki dan perempuan secara seimbang sesuai dengan kadar keimanan dan ketakwaan menjadi salah satu upaya jalan tengah yang harus ditempuh para Muslim dan Muslimat.
Epistemologi Ilmu Pengetahuan Islam Klasik dan Kontemporer
Authors: Mustofa Taufik , Fatah Natsir Nanat , Haryanti Erni
Published: June 2023

Epistemology merupakan salah satu cabang ilmu filsafat yang mempelajari tentang hakikat ilmu pengetahuan dan metode atau cara untuk memperoleh ilmu pengetahuan. Kajian epistemology yang cukup berpengaruh dan berkembang pada saat ini lebih banyak didominasi oleh pemikir barat dibandingkan para pemikir Islam. Pemikiran Islam mengalami berbagai dinamika dan pasang surut yang luar biasa sejak periode Islam awal atau klasik sampai dengan abad modern atau kontemporer. Pemikiran Islam yang berkembang juga tidak terlepas dari peran pemikiran, historisitas, sosial budaya termasuk epistemologi. Persentuhan dan pertemuan pemikiran Islam dengan semua elemen-elemen tersebut telah mengkonstruksi bangunan epistemologi sendiri dalam pemikiran Islam. Tulisan ini ingin menelusuri dan menganalisis diskursus epistemologi yang berlangsung dalam pemikiran Islam serta perkembangannya pada periode klasik dan kontemporer.
Pendidikan Wanita Dalam Al-Qur’an Perspektif Ahli Tafsir Dan Relevansinya Dengan Pendidikan Agama Islam
Authors: Nabilatul Fauziah Debibik , Herdiana Yayat
Published: June 2023

Kondisi wanita sebelum risalah kenabian diwarnai ketidakadilan dari lingkungan sekitarnya. Adapun Islam adalah agama pertama yang memberikan wanita atas hak-haknya dan mengembalikan kemuliannya. Pada tulisan ini akan dibahas pendidikan wanita dalam Al-Qur’an perspektif mufassirun yang terdapat dalam kisah Maryam dalam surah Ali Imran ayat 35-37 dan surah Maryam ayat 16-36, hubungan nilai pendidikan wanita dari penafsiran mufassirun terhadap kisah Maryam tersebut dengan pendidikan agama Islam dan implementasi nilai pendidian wanita dari penafsiran mufassirun terhadap kisah Maryam dalam lingkup program studi Pendidikan Agama Islam Fakultas Agama Islam Universitas Singaperbangsa Karawang.
MEKANISASI PROSES PRODUKSI PUPUK ORGANIK PADA KELOMPOK TANI SUMBER REJEKI BALIKPAPAN
Authors: Manta Faisal , Suprapto Sena Sukmananda , Haliq Ridhwan , Haryono Hadhimas Dwi , Nuryanto Firman Ali , Caesar Aji Bagas , Aman Ismail , Priatna Muhammad Adzar , Fiqriadi Muhammad , Triatmojo Muhammad , Wirayudha Reihanda Fikri , Hanifudin Reza Naufal , Amril Rizki Rama Aditia , Gunawan Syahrul , Silalahi Yonathan Parsualin Lobo
Published: June 2023

Usaha pengolahan sampah sebagai upaya untuk dapat meminimalisir dampak negatif dan meningkatkan nilai kemanfaatan dari sampah terus digalakan. Kelompok tani Sumber Rejeki di Kecamatan Balikpapan Utara Kalimantan Timur fokus terhadap pertanian organik dengan mengolah sampah menjadi berbagai jenis pupuk padat dan cair. Proses pengolahan dilakukan secara manual sehingga berdampak terhadap kualitas dan kuantitas pupuk yang dihasilkan. Pelaksanaan program pengabdian masyarakat ITK terhadap mekanisasi proses pengolahan sampah organik dilakukan untuk mampu menghasilkan produk pupuk berkualitas baik dengan kapasitas mampu memenuhi kebutuhan petani. Proses mekanisasi diwujudkan dengan membuat alat pengolah pupuk organik (APPO) mampu menghaluskan bahan organik dengan kekerasan tinggi seperti ranting pohon, pelepah kelapa, hingga sabut kelapa. Alat Pengolahan Pupuk Organik telah dirancang dengan sistem rotari dilengkapi mata pisau menyudut. Pengujian terhadap unjuk kerja alat tersebut dilakukan terhadap bahan serabut kelapa dan pelepah pisang yang merupakan bahan pembuatan pupuk organik. Hasil pengujian menggunakan APPO diperoleh bahwa hasil pemotongan yang lebih halus dengan waktu yang lebih singkat, sehingga berdampak terhadap peningkatan kualitas dan kapasitas produksi pupuk kelompok tani Sumber Rejeki.