bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of TM6SF2 rs58542926 with Hepatic and Extrahepatic Alterations in Chronic Hepatitis C Patients
Authors: Abdul Mohi I. Mohammed , Vitiello Adriana , Ghassabian Hanieh , Eltahir Heba M. , Hassan Elham Ahmed , Bekhit Amany A. , Ahmed Abo Bakr F. , Ahmed Hany E.A. , Abouzied Meky M. , Elbadawy Hossein , Calistri Arianna , Alvisi Gualtiero , Thabet Khaled
Published: August 2021

Human genetic variants play major roles in predicting and prognosis of several diseases. The effect of rs58542926 variant in transmembrane 6 superfamily member 2 (TM6SF2) gene on liver fibrosis among patients with chronic hepatitis C (CHC) is still debatable. The aim of this study is to investigate the possible effects of this variant in CHC patients. The study comprised 351 subjects: 250 CHC patients with different fibrosis stages (F0-F4) and 101 healthy volunteers. TM6SF2 (rs58542926) genotype was determined for all subjects. Blood samples were collected for complete blood count and biochemical analysis and cohort subjects were genotyped for the variant TM6SF2 rs58542926. Fibrosis staging was performed using Fibrotest and Fibroscan standard tests. The presence of the minor allele was significantly associated with severe liver fibrosis, as well as thrombocytopenia as an extrahepatic alteration. In addition, there was a significant association between the minor allele and lower thrombopoietin levels. The association of TM6SF2 genotype with thrombocytopenia was explored by measuring plasma thrombopoietin (TPO) levels for CHC patients. The results showed an association with extrahepatic alteration (thrombocytopenia) through its effect on plasma TPO level, and consequently on platelets production, which raises questions about the role of this variant in HCV treatment outcome. In conclusion, the occurrence of the minor allele of the variant rs58542926 can be linked to severe fibrosis stages as well as thrombocytopenia, enabling this variant to be used as a diagnostic pharmacogenetic marker for predicting the risk of fibrosis onset in CHC patients.
Factors associated with the development of secondary cancers after radioiodine therapy in differentiated thyroid cancer: A multicenter retrospective study
Authors: Hong Chae Moon , Shin Ji-Yeon , Kim Byeong Il , Song Ho-Chun , Yoon June-Kee , Won Kyoung Sook , Kim Seong-Min , Cho Ihn Ho , Jeong Shin Young , Lee Sang-Woo , Lee Jaetae
Published: August 2021

Purpose

The objective of this study was to estimate the incidence of secondary cancers and the factors associated with their development among patients who underwent radioiodine therapy (RIT) with differentiated thyroid cancer.
Methods

We retrospectively collected medical records for patients who underwent first RIT between January 1, 2000 and December 31, 2005 from seven tertiary hospitals in South Korea after total thyroidectomy for differentiated thyroid cancer. Cancer incidence and calculated standardized rate ratio was compared with Korean cancer incidence data. The association between the development of secondary cancers and various parameters was analyzed by Cox-proportional hazard regression.
Results

A total of 3106 patients were included in this study. Mean age at the time of diagnosis of thyroid cancer was 45.7 ± 13.3 years old, and 2669 (85.9%) patients were female. The follow-up period was 11.9 ± 4.6 (range, 1.2–19.6) years. A total of 183 secondary cancers (5.6%), which included 162 solid and 21 hematologic cancers occurred in 173 patients. There was no significant difference between solid cancer incidence in our study population who underwent RIT and the overall Korean population, but the incidence of hematologic cancers and total cancer in our study was significantly higher compared with that of the Korean population. A multivariate analysis identified independent prognostic factors for the development of secondary cancer including age at 1st RIT, male, and total cumulative dose over 200 mCi.
Conclusion

We need to assess the risk benefit for patients who receive over 200 mCi of a total cumulative dose.
Quantitative Evaluation of Weathering Degree through Fuzzy-AHP Method and Petrophysics Analysis for Sandstone Carvings
Authors: Shao Mingshen , Xu Dong , Wang Yuchao , Wang Ziyi , Liang Xingzhou , Li Li
Published: August 2021

Study on weathering degree assessment of sandstone carvings play an important role in scientific conservation. However, current state of research on weathering assessment cannot reach the needs of scientific evaluation. In this study, the selected sandstones originate from Jurassic and, soluble salt and acid simulation experiments were carried out on standard samples. The weight, specimen surface hardness, ultrasonic velocity and water absorption are measured by means of the non-destructive methods. Furthermore, mineral composition and petrophysical properties are analyzed on small specimens in laboratory. It is revealed that the main mineral, such as quartz and feldspar, is shown by oblate and prolate in shape. Moisture content has great influence on compressive strength of rock samples. Rock porosity increases with deterioration process. The decrease of quality, surface hardness and ultrasonic velocity with increasing cycles. Conversely, water absorption capillary increase over cycles. In addition, Fuzzy-AHP method is adopted to further evaluate weathering degree on experiment samples. Results in macroscopic show that the value of weathering degree is 0.3271 for sodium sulfate solution, which is shown by moderate weathering; 0.1951 for pH = 1 sulfuric acid and 0.1060 for pH = 2 sulfuric acid, which is characterized by low weathering; 0.0516 for pH = 3 sulfuric acid and 0.0421 for pH = 4 sulfuric acid, belonging to very low weathering.
Effect of fluensulfone on different functional genes of root-knot nematode Meloidogyne incognita
Authors: Hada Alkesh , Singh Divya , Venkata Satyanarayana Kranti Kavalipurapu Veera , Chatterjee Madhurima , Phani Victor , Rao Uma
Published: August 2021

Meloidogyne incognita is an obligate plant-parasitic nematode causing serious damage to agricultural crops. Major constraints in nematode management arose due to the limited availability of non-fumigant nematicides in conjunction with the considerable ill effects of fumigants on human and non-target organisms. Recently, fluensulfone has been reported to be an effective non-fumigant nematicide against plant-parasitic nematodes and the model nematode Caenorhabditis elegans. The nematicidal efficacy varies according to its concentration at the time of application, exposure timing, nematode species variability, and even across subpopulations within the same species. It interferes with the key physiological processes of nematodes, like motility, behavior, chemosensation, stylet thrusting, infectivity, metabolism, lipid consumption, tissue integrity, oviposition, egg hatching, and survival. However, the molecular basis of these multivariate physiological anomalies is still largely unknown. Quantitative real-time PCR was carried out to understand the acute transcriptional perturbation of 30 functional genes associated with key physiological and life processes in a M. incognita population, following exposure of 10, 50, and 100 ppm of fluensulfone for 5 and 10 hr. The chemical treatment resulted in significant downregulation of all the neuropeptidergic genes, with concomitant repression of majority of genes related to chemosensation, esophageal gland secretion, parasitism, fatty acid metabolism, and G-protein coupled receptors. Collectively, the parasitism genes were found to be perturbed at highest magnitude, followed by the GPCRs and neuropeptidergic genes. These results establish the wide ranging effect of fluensulfone on various metabolic and physiological pathways of nematode.
Comments on foliated gauge theories and dualities in 3+1d
Authors: Hsin Po-Shen , Slagle Kevin
Published: August 2021

We investigate the properties of foliated gauge fields and construct several foliated field theories in 3+1d that describe foliated fracton orders both with and without matter, including the recent hybrid fracton models. These field theories describe Abelian or non-Abelian gauge theories coupled to foliated gauge fields, and they fall into two classes of models that we call the electric models and the magnetic models. We show that these two classes of foliated field theories enjoy a duality.
We also construct a model (using foliated gauge fields and an exactly solvable lattice Hamiltonian model) for a subsystem-symmetry protected topological (SSPT) phase, which is analogous to a one-form symmetry protected topological phase, with the subsystem symmetry acting on codimension-two subregions. We construct the corresponding gauged SSPT phase as a foliated two-form gauge theory. Some instances of the gauged SSPT phase are a variant of the X-cube model with the same ground state degeneracy and the same fusion, but different particle statistics.
Biological Deacidification Strategies for White Wines
Authors: Gardoni E. , Benito S. , Scansani S. , Brezina S. , Fritsch S. , Rauhut D.
Published: August 2021

Traditionally, the use of malolactic fermentation gives rise to microbiologically stable wines. However, malolactic fermentation is not free from possible collateral effects that can take place under specific scenarios. The present work tests the influence of different biological deacidification strategies on the volatile and non-volatile components of white must from Germany. The study compared mixed cultures of Lachancea thermotolerans and Schizosaccharomyces pombe and a pure culture of Sc. pombe to the classical biological deacidification process performed by lactic acid bacteria. Strains of Oenococcus oeni and Lactiplantibacillus plantarum were co- or sequentially inoculated with S. cerevisiae to carry out malolactic fermentation. Different fermentation treatments took place at a laboratory scale of 0.6 L in vessels of 0.75 L. The instrumental techniques Fourier-transform mid-infrared spectroscopy (FT-MIR), high performance liquid chromatography (HPLC) and gas chromatography–mass spectrometry (GC-MS) were used to evaluate different chemical parameters in the final wines. The results showed the ability of Sc. pombe to consume malic acid in combination with L. thermotolerans without using S. cerevisiae or lactic acid bacteria. Fermentations involving Sc. pombe consumed all the malic acid, although they reduced the concentrations of higher alcohols, fatty acids and acetic acid. Simultaneous alcoholic and malolactic fermentations reduced malic acid by about 80%, while classical malolactic fermentation reduced it by 100%. Fermentations involving L. thermotolerans produced the highest lactic acid, ester and glycerol concentrations.
MediaLab Universidad Panamericana: Una experiencia heutagógica en la formación en medios de comunicación durante el confinamiento por Covid19
Authors: Flores Heymann Bernardo
Published: August 2021

Este artículo explora los resultados que se obtuvieron en el laboratorio de medios de la Escuela de Comunicación de la Universidad Panamericana durante la pandemia de Covid19 en el desarrollo de habilidades y competencias, así como la auto determinación del aprendizaje técnico por parte de los estudiantes bajo un diseño heutagógico del plan formativo. Asimismo, profundiza en las áreas de oportunidad que se descubrieron durante su ejecución y las posibles mejoras para garantizar el cumplimiento de los objetivos.
Formación e investigación cinematográficas en línea en tiempos de pandemia: estado de la cuestión en España (marzo 2020-febrero 2021: una muestra)
Authors: López Yepes Alfonso
Published: August 2021

Se presenta una muestra o selección de actuaciones originadas por la pandemia declarada desde marzo de 2020, cuya situación a febrero de 2021 sigue vigente aunque en parte -todavía- controlada por la vacunación que a nivel global se está aplicando. El virus ha afectado -como en todos los ámbitos del conocimiento- a todo el marco de la industria cinematográfica de la preproducción-producción-postproducción, distribución y exhibición, a la par que a la formación e investigación. Varios son los epígrafes que articulan este trabajo en estrecha relación en todo momento con el acceso abierto, precisamente para contrarrestar en lo posible la situación provocada por la pandemia. De modo que a través de plataformas diversas se pueda programar y acceder a numerosas manifestaciones cinematográficas, incluso de manera gratuita, difundiéndose a nivel global y en tiempo real. En ese sentido la producción fílmica en cuanto a formación e investigación, sustentada en clases magistrales, conferencias, seminarios en línea -webinars- y otras manifestaciones, en ebullición de redes sociales. Se alude en consecuencia a herramientas e instrumentos de producción, recuperación y difusión vía portales, canales y redes colaborativas, para distribución y difusión informativa del conocimiento cinematográfico. En ese sentido se remite a una pequeña muestra o selección de realizaciones institucionales especializadas y de medios de comunicación en relación con el cine y la pandemia, con incluso alguna referencia iberoamericana estrechamente relacionada con la formación e investigación fílmicas. Y un anexo final que proporciona un corpus, accesible permanentemente, de fuentes de consulta o referencia cinematográficas en línea, de elaboración anterior a estas fechas, pero todavía en vigencia, susceptible de ser utilizado como materiales didácticos para la docencia e investigación, en tiempos o no de pandemias, virus o cualquier otro tipo de desastre o siniestro global.
Coal Fly Ash Waste, a Low-Cost Adsorbent for the Removal of Mordant Orange Dye from Aqueous Media
Authors: Rosa Teresa , Martins Angela , Santos Maria , Trindade Teodoro , Nunes Nelson
Published: August 2021

In this study, a coal fly ash material generated in a Portuguese coal thermal powerplant was tested as a low-cost adsorbent to remove dye molecules. Pre-treatment of the coal fly ash samples was not performed in order to reduce end use cost. Physical and chemical characterization revealed their inert nature and low effects lixiviation in aqueous media. Preliminary adsorption studies include adsorbent quantity, and adsorption kinetics. The adsorption studies focused on Mordant Orange 1 (Mo1) dye, but two other molecules, Rhodamine B (RhB) and Methylene Blue (MeB) were also included for comparison reasons. The adsorption isotherms were tested with different models including Langmuir, Freundlich and modified Langmuir-Freundlich. The effect of temperature, pH and unburn carbon in the adsorption process were also studied. The results show that adsorption capacity of the coal fly ash occurs mainly due to electroestatic interactions between the adsorbent surface and the adsorbate, which depends on the pH of the aqueous media and the surface chemistry of the material, quantified by the point of zero charge, pHpzc. These joint effects are responsible for the higher retention of Mo1 that is about 16 times higher, when compared to the other two molecules tested.
The Effectiveness of Bank Aceh Syariah Conversion Decisions
Authors: Pambuko Zulfikar Bagus , Pramesti Diesyana Ajeng
Published: August 2021

Abstract: Since 2008, Indonesia has had a particular policy for Islamic windows to spin off into full-fledged Islamic banks separate from their conventional parent if they meet the criteria. In the case of Bank Aceh Syariah, since Q3 2016, the spin-off has been done through a conversion mechanism from Bank Aceh to Bank Aceh Syariah. The study aims to analyze the effectiveness of conversion decisions in Bank Aceh Syariah. Non-parametric test with the Wilcoxon signed-rank is used to analyze the banking performance due to the conversion. The performance indicators tested in the study are capital adequacy, liquidity risk, profitability, and management efficiency over Q2 2014 until Q3 2018. The results suggest that the conversion decision of Bank Aceh Syariah is effective in correcting the non-performing financing (NPF) ratio but declining the level of profitability through ROA, ROE, and NOM ratio. Thus, the spin-off decision through the conversion mechanism needs to forecast the future financial performance and the effort to fulfill sharia compliance.Abstrak: Sejak 2008, Indonesia memiliki kebijakan khusus bagi perbankan syariah yang mewajibkan UUS untuk melakukan spin-off menjadi BUS yang terpisah dari bank konvensional induknya jika telah memenuhi kriteria. Pada kasus Bank Aceh Syariah, sejak kuartal III 2016 telah dilakukan spin-off melalui mekanisme konversi dari Bank Aceh menjadi Bank Aceh Syariah. Tujuan penelitian ini adalah untuk menganalisis efektivitas keputusan konversi Bank Aceh Syariah. Pengujian non parametrik dengan uji Wilcoxon digunakan untuk menganalisis kinerja keuangan akibat konversi. Indikator kinerja yang diuji dalam studi ini adalah permodalan, risiko likuiditas, profitabilitas, dan efisiensi manajemen pada periode Q2 2014 hingga Q3 2018. Hasil penelitian ini menunjukkan bahwa keputusan konversi Bank Aceh Syariah efektif dalam memperbaiki rasio pembiayaan bermasalah (NPF), namun menurunkan tingkat profitabilitas melalui ROA, ROE, dan NOM. Dengan demikian, keputusan spin-off melalui konversi perlu mempertimbangkan capaian kinerja keuangan di masa mendatang, selain sebagai upaya pemenuhan kepatuhan terhadap syariah.
Optimal design of integrated main supporting structure with ultra-light weight and high stability for space camera
Authors: Yin Xiaolin , Zhang Binzhi , Zhang Xin , Wei Lei , Zhang Le , Song Chi , Yin Longhai
Published: August 2021

To ensure excellent performance of a micro reflective space camera, an integrated main supporting structure (IMSS) combined with a thin-walled tube and a supporting rod structure design is applied in this study. Firstly, this paper covers the design and comparison of the performance of three traditional types of main supporting structures (MSS), including thin-walled cylinder type, rod-supporting type and truss type. Then, an IMSS combined with a thin-walled tube and a supporting rod structure is described. In addition, a multi-objective integrated optimization method which allows automatic modeling, analysis, calculation and optimization is proposed. Further, the influence of the supporting rod angle on the structure performance is studied, the performance of stiffness, deformation and mass is better when the height ratio of the rod-structure and the thin-walled cylinder is 6:1. The IMSS mass is only 0.56 kilograms, that is 11.2 % of the total mass of the payload, and the maximum deformation on the supporting bar is no more than 4.5 nm. Finally, the IMSS performance is analyzed by the finite element method and experimental verification, and the first order frequency is up to 192.7 Hz. The degree of light weight is significantly better than that of the traditional structures. The results of the experiment further prove the stability of the IMSS.
The Investigation of Fluorescence Biothiol Sensor Properties of 2-(N-hexyl-carbazole-3'-yl)-4- formylpyridine
Authors: ALTINÖLÇEK Nuray , BATTAL Ahmet
Published: August 2021

The biothiol sensor properties of 2-(N-hexyl-carbazole-3'-yl)-4-formylpyridine molecule were examined. This probe has carbazole moiety as a fluorophore and aldehyde group as a recognition site. Three different biothiol molecules as an analytes were chosen that they are cysteine (Cys), homocysteine (Hcy) and glutathione (GSH). We monitored the adduct formation between probe and analyte (biothiols) by 1H NMR, MS, UV-vis and PL Spectrometers.
The Social and Economic Impacts of Novel Coronavirus Pandemic on Construction Sector and its Professionals
Authors: GENÇ Olcay
Published: August 2021

The goal of this study is, in an unexpected exceptional situation such as Covid-19 outbreak, to demonstrate how the extent of understanding of the situation and its social and economic impact on the construction sector and on its practitioners can be defined and exposed. Hence, to provide insights to the practitioners to prepare the sector and its professionals for the next extraordinary situation. A questionnaire survey is prepared and delivered personally and via the Chamber of Civil Engineers to the civil engineers who work for public or private sectors, and then a comparative analysis is carried out. The exploratory results of the study show that the civil engineers follow precaution rules against Covid-19, they stay home unless compulsory matters, they are highly concerned about global, national and family economies after coronavirus pandemic and, while the majority of the civil engineers somehow continue working during the pandemic, only a very small portion of the private sector companies bankrupt.
Jet Giriş Genişliğinin Isı Transferi ve Akış Yapısına Olan Etkisinin Araştırılması
Authors: ALNAK Doğan Engin , KARABULUT Koray
Published: August 2021

Bu çalışmada, farklı jet giriş genişliklerindeki kanallarda bulunan düz yamuk ve ters yarım daire şeklinde iki farklı desene sahip bakır plakalı yüzeylerden hava jeti akışı ile olan ısı transferi sayısal olarak araştırılmıştır. Sayısal hesaplamalar, zamandan bağımsız ve üç boyutlu olarak enerji ve Navier-Stokes denklemlerinin k-ε türbülans modelli Ansys-Fluent bilgisayar programı kullanılarak çözülmesiyle gerçekleştirilmiştir. Kanalların üst ve alt yüzeyleri adyabatik olup desenli yüzeylere sabit ısı akısı uygulanmıştır. Jet giriş genişlikleri Dh ve 1,25Dh’dır. Çalışmanın sonuçları, literatürdeki çalışmanın sayısal ve deneysel sonuçlarıyla karşılaştırılmış ve birbirleriyle uyumlu oldukları görülmüştür. Sonuçlar, her bir desenli yüzey için ortalama Nu sayısı ve yüzey sıcaklık değişimi olarak sunulmuştur. Jet ve plaka arası mesafe (H/Dh) 12’de Re=9000 için ters yarım daire desenli yüzeylerin ortalama Nu sayısı, düz yamuk desenli yüzeylerden yaklaşık %56 daha fazladır.
L ve T Tesisat Bağlantı Elemanlarında Nanoakışkan Kullanımında Akış Karakteristiklerinin Sayısal Olarak İncelenmesi
Authors: TOKGÖZ Nehir , AVCI Mürüvvet , ERDİNÇ Mehmet Tahir , KAŞKA Önder
Published: August 2021

Yapılan bu çalışmada endüstriyel sistemlerde en çok kullanılan 2 farklı tesisat bağlantı parçasının (L, T) içerisinden nanoakışkan geçirilip, bu bağlantı parçalarının basınç düşüşleri ve basınç kayıp katsayıları sayısal olarak incelenmiştir. Nanoakışkan, temel akışkan su alınarak içerisine farklı konsantrasyonlarda alüminyum, bakır ve titanyum esaslı nanoparçacıkların eklenmesiyle elde edilmiştir. Artan konsantrasyonun basınç kaybı ve akış yapısı üzerinde etkisini incelemek için farklı konsantrasyonlarda farklı nanoakışkanlar incelenmiştir ((A2O3, %0,3, %0.5,
%1, %2, %3) ve CuO (%1, %2, %4). Nanoakışkanların termofiziksel özellikleri daha önce yapılmış olan çalışmalardan alınmıştır. Hesaplama sonuçları, literatürdeki sonuçlar ile doğrulanmıştır. Sayısal çözümlemelerde yaygın olarak tercih edilen standart k- ε ve standart k- ω türbülans modeli olmak üzere 2 farklı model kullanılmıştır. Elde edilen hesaplar sonucunda incelenen her akışkanda, konsantrasyon arttıkça viskozitenin artışı ile yerel kayıpların da arttığı ortaya konulmuştur. En uygun modelin her iki bağlantı parçası için de standart k-ε olduğu belirlenmiştir.
Experiments based comparative evaluations of machine learning techniques for leak detection in water distribution systems
Authors: Kammoun Maryam , Kammoun Amina , Abid Mohamed
Published: August 2021

Leakage in water distribution systems is a significant long-standing problem due to the huge economic and ecological losses. Different leak detection studies have been examined in literature using different types of technologies and data. Currently, although machine learning techniques have achieved tremendous progress in outlier detection approaches, they are still limited in terms of water leak detection applications. This research aims to improve the leak detection performances by refining the choices of learning data and techniques. From this perspective, commonly used techniques for leak detection are assessed in this paper, and the characteristics of hydraulic data are investigated. Four intelligent algorithms are compared, namely k-nearest neighbors, support vector machines, logistic regression, and multi-layer perceptron. This study focuses on six experiments based on identifying outliers in various packages of pressure and flow data, yearly data, seasonal data, night data, and flow data difference to detect leakage in water distribution networks. Different scenarios of realistic water demand in two networks from the benchmark dataset LeakDB are used. Results demonstrate that the leak detection accuracy varies between 30% and 100% depending on the experiment and the choices of algorithms and data.
A comprehensive comparative analysis of deep learning tools for modeling failures in smart water taps
Authors: Offiong N. M. , Wu Y. , Muniandy D. , Memon F. A.
Published: August 2021

Predicting early-stage failure in smart water taps (SWT) and selecting the most efficient tools to build failure prediction models are many challenges that water institutions face. In this study, three Deep Learning (DL) algorithms, i.e., the Long Short-Term Memory (LSTM), Convolutional Neural Network (CNN) and Bi-directional Long Short-Term Memory (BiLSTM), were selected to analyse and determine the most appropriate among them for failure prediction in SWTs. This study uses a historical dataset acquired from smart water withdrawal taps to determine the most efficient DL neural network architecture for failure prediction in the SWT, leading to a hybrid model's development. After a comprehensive evaluation of the three ML models, findings show that a hybrid combination of the CNN and Bi-LSTM (CNN-BiLSTM) models is a better solution for investigating failures in the SWT.
Studi Evaluasi Pengerukan Sedimen Pada Central Sediment Sump di Lokasi Penambangan Emas PT. Bumi Suksesindo Kabupaten Banyuwangi
Authors: Cunanda Yana , Asmaranto Runi , Wicaksono Prima Hadi
Published: August 2021

Central Sediment Sump is the largest sedimentation pond in the gold mine of PT. Bumi Suksesindo. Central Sediment Sump accommodates sediment from region Central Waste Dump (CWD), Pit E, and Pit B West. There is an increases in ore production began in 2018 makes the mining rate up to 8,1 million tons/year. This result increased sediment rates that are accommodated by Central Sediment Sump. The evaluation in this study is based on the amount of dredged sediment volume during 2018 with the volume of sediment that has been accommodated in the Central Sediment Sump. The volume of sediment that came from erosion in the Central Sediment Sump catchment area will be accommodated in the Central Sediment Sump. Dredged sediment volume depends on the bucket size excavators, excavator cycle times, and excavator work times. Excavator work time concern with the time needed to move the sediment volume that is already determined. The results evaluation of dredging sediment will describe sufficient whether or not sediment dredging in 2018 to dredge the sediment accommodated in Central Sediment Sump. Based on the results of this study the volume of sediment accommodates in Central Sediment Sump is 2.004.551,730 m3. Dredged sediment volume during 2018 is 11.755,310 m3. Therefore dredging sediment in 2018 insufficient to dredge all the sediment accommodates in Central Sediment Sump.Â Central Sediment Sump merupakan kolam pengendapan sedimen terbesar di Penambangan EmasÂ  PT. Bumi Suksesindo. Central Sediment Sump menampung sedimen dari kawasan Central Waste Dump (CWD), Pit E, dan Pit B West. Adanya peningkatan produksi bijih mulai tahun 2018 menjadikan laju penambangan hingga 8,1 juta ton/tahun. Peningkatan ini mengakibatkan meningkatnya laju sedimen yang ditampung Central Sediment Sump. Evaluasi yang dilakukan pada studi ini berdasarkan pada jumlah volume sedimen terkerukÂ  selama tahun 2018 terhadap volume sedimen yang tertangkap di Central Sediment Sump. Volume sedimen yang berasal dari hasil erosi di daerah tangkapan air Central Sediment Sump akan tertangkap di Central Sediment Sump. Volume sedimen terkeruk tergantung pada ukuran bucket excavator, waktu siklus excavator, dan waktu kerja excavator. Waktu kerja excavator menggambarkan waktu yang diperlukan untuk memindahkan volume sedimen yang sudah ditentukan. Hasil evaluasi pengerukan sedimen akan menggambarkan cukup atau tidaknya pengerukan sedimen tahun 2018 untuk mengeruk sedimen yang tertangkap di Central Sediment Sump. Berdasarkan hasil studi ini diperoleh volume sedimen yang tertangkap di Central Sediment Sump sebesar 2.004.551,730 m3. Volume sedimen terkeruk selama tahun 2018 sebesar 11.755,310 m3. Sehingga pengerukan sedimen tahun 2018 tidak mencukupi untuk mengeruk seluruh volume sedimen yang tertangkap di Central Sediment Sump.
Studi Pola Operasi Normal Waduk Mamak di Kabupaten Sumbawa Provinsi Nusa Tenggara Barat
Authors: Kurnianto Noval Irfan , Wahyuni Sri , Sholichin Moh.
Published: August 2021

The reservoir operation of Mamak reservoir in Sumbawa Regency Province of West Nusa Tenggara with trial and error method and itâ€™s also not equipped with Rule Curve for Reservoir Operation so Itâ€™s faced with limited water availability in water releasing for dry season.The purpose of this study was to analyze about potential inflow and the irrigation water requirement based on planting pattern scenario. From the analysis that has been done is expected to provide an overview about the rule curve of normal operation. ByÂ  Â± 81,87 million m3 of potential inflow in wet season and Â± 41,14 millionÂ  m3 in dry season, the lowest irrigation water requirement was found on MT â€“ I December-1, in wet season need to apply K factor = 0,70 for MT-I and K factor = 0,60 for MT-II to reduce that number of irrigation water requirement by Â±38,73 million m3.In analyzing irrigation water requirement, It also planned with three period of planting pattern scenario so the amount of irrigation water requirement equals to 61,23 million m3 in wet season, and in dry season need to apply K factor = 0,70 for MT-I and K factor = 0,60 for MT-II. Operator can set water level on normal operation area based on the rule curve of normal operation.
Studi Pola Operasi Pintu Berdasarkan Routing Kapasitas Pengaliran Intake Menara Pada Bendungan Semantok Kabupaten Nganjuk
Authors: Rahmadani Siska , Sayekti Rini Wahyu , Sisinggih Dian
Published: August 2021

Semantok Dam was build to supply water for irrigation with total area of the irrigated is 1825 ha including six weirs with a minimum requirement of 3,943 m3/s. To distribute the water for irrigated, so in this study need to use the operating pattern based on the intake routing capacity in main DAM with the intake tower.Â  Â The operating pattern of the intake door opening needs to be appropriate to prevent problems in water distribution with one-valve and two-valves. The total height loss that happens along intake tower is 6,135 m, here in after used for routing. Â In operation pattern routing method in one year using one-valve itâ€™s fulfill the discharge 83,33% and with two-valve discharge operation pattern fullfilled 16,67%. Furthermore in the escape channel thereâ€™s flow affected by the valve, itâ€™s sub critical flow and also stilling basin ogee IV.Â Bendungan Semantok dibangun untuk menyuplai kebutuhan air irigasi Â seluas 1825 ha meliputi enam bendung (Bendung Rejoso, Bendung Margomulyo, Bendung Ngomben, Bendung Jatirejo, Bendung Janeng, dan Bendung Jati) dengan debit suplai sebesar 3,943 m3/dt. Guna menyuplai kebutuhan air irigasi, maka dalam studi ini merencanakan pola operasi pintu berdasarkan routing kapasitas intake di bendungan dengan bangunan intake Menara. Pola operasi bukaan pintu intake perlu disesuaikan guna mencegah masalah pendistribusian air dengan bukaan katup yang digunakan 1 (satu) katup dan 2 (dua) katup. Kehilangan tinggi yang terjadi sepanjangÂ  intake Menara sebesar 6,135 m yang selanjutnya digunakan untuk melakukan routing. Pada pola operasi metode routing dalam satu tahun menggunakan Â 1 (satu) katup memenuhi debit suplai sebesar 83,333% dan pola operasi 2 (dua) katup memenuhi debit suplai 16,667%. Selanjutnya saluran pengarah akhir terdapat aliran yang mempengaruhi setelah pintu katup yaitu aliran sub kritis serta tipe peredam energi ogee IV.
Analisa Indeks Kinerja Daerah Irigasi Taposan Kecamatan Dringu Kabupaten Probolinggo Menggunakan Software PDSDA-PAI
Authors: Pranoto Lendi Dwi , Wahyuni Sri , Lufira Rahmah Dara
Published: August 2021

Kabupaten Probolinggo merupakan salah satu lumbung bawang merah nasional di wilayah Jawa Timur (37%), salah satu wilayah Di Kabupaten Probolinggo yang ikut berkontribusi akan hal tersebut adalah Daerah Irigasi Taposan yang terletak di Kecamatan Dringu, dimana kewenangannya berada di bawah UPT SDA Kabupaten Probolinggo. Salah satu upaya untuk menjaga produktivitas bawang merah adalah dengan melakukan kegiatan pemeliharaan dan rehabilitasi pada Daerah Irigasi Taposan, oleh karena itu besarnya nilai indeks kinerja sistem sangat diperlukan untuk menjaga serta meningkatkan produktivitas dalam menstabilkan nilai indeks kinerja sistem irigasi yang ada. Untuk memperhitungkan besarnya indeks kinerja sistem pada Daerah Irigasi Taposan dilakukan penilaian pada aset irigasi dengan menggunakan metode penilaian pada PerMen PUPR No 12/PRT/M/2015, dan juga dibantu dengan menggunakan software PDSDA-PAI Versi 2.0. Dari kedua metode yang digunakan didapatkan hasil Indeks Kinerja sebesar 68,43% dari metode Blangko dan 65,22% dari metode software PDSDA-PAI, sehingga disimpulkan kondisi dari Daerah irigasi Taposan terbilang masih cukup bagus dengan Indeks Kinerja 65%. Selanjutnya dengan kondisi yang ada hanya diperlukan pemeliharaan secara rutin.
Analisa Indeks Kinerja Daerah Irigasi Kedung Bantal Kecamatan Pagerwojo Kabupaten Tulungagung dengan Menggunakan Software PDSDA-PAI Versi 2.0
Authors: Sebastian Bintang , Dermawan Very , Sisinggih Dian
Published: August 2021

The cause of food shortages in several areas in Tulungagung Regency is due to a decrease in agricultural productivity as a result of a decrease in the performance of the irrigation system, such as what happened in the Kedung Bantal Irrigation Area. In an effort to prevent the decline in the performance of the irrigation system, monitoring of the performance of the irrigation system is conducted. Irrigation system performance index is needed to determine feasibility and solutions, so to simplify the calculation of the irrigation system performance index value helped by using the PDSDA-PAI Version 2.0 software. Based on the results of the irrigation system performance index assessment using the PDSDA-PAI version 2.0 software, the performance index value was 77.35%, while for the calculation of the irrigation system performance index value using blank, the performance index value was 74.13%. The difference in the calculation of the irrigation system performance index value that occurs is due to differences in the assessment parameters between the PDSDA-PAI Version 2.0 software and blanks, however the results of the assessment of the two methods state that the conditions of the Kedung Bantal Irrigation Area are in good condition and only require maintenance activities.Â Penyebab terjadinya kekurangan pangan di beberapa wilayah di Kabupaten Tulungagung dikarenakan adanya penurunan produktivitas pertanian sebagai dampak dari penurunan kinerja sistem irigasi, seperti yang terjadi pada Daerah Irigasi Kedung Bantal. Sebagai upaya untuk mencegah turunnya kinerja sistem irigasi maka dilakukan pemantauan terhadap kondisi kinerja sistem irigasi. Indeks kinerja sistem irigasi diperlukan untuk menentukan kelayakan dan solusi, sehingga untuk mempermudah perhitungan nilai indeks kinerja system irigasi dibantu dengan menggunakan software PDSDA-PAI Versi 2.0. Berdasarkan hasil penilaian indeks kinerja sistem irigasi dengan menggunakan software PDSDA-PAI Versi 2.0 diperoleh nilai indeks kinerja sebesar 77,35%, sedangkan untuk perhitungan nilai indeks kinerja sistem irigasi dengan menggunakan blangko didapatkan nilai indeks kinerja sebesar 74,13%. Selisih perhitungan nilai indeks kinerja sistem irigasi yang terjadi disebabkan oleh perbedaan parameter penilaian antara software PDSDA-PAI Versi 2.0 dengan blangko, akan tetapi hasil penilaian dari kedua metode menyatakan bahwa kondisi Daerah Irigasi Kedung Bantal dalam keadaan baik dan hanya memerlukan kegiatan pemeliharaan.
The Legal Implications of a Sale of Property by the Malaysian Developers under the Private Lease Scheme: In two minds?
Authors: Abu Bakar Noraziah , Azmi Ruzita , Sufian Azlinor , Saripan Hartini
Published: August 2021

This paper aims to evaluate the legal implications of the private lease scheme (PLS) for a property sale by the developers. It mainly relies on statutes and court cases as its primary sources of information. PLS is selling a lease to purchasers by the developers. If purchasers were misled to believe a property is purchased and not the purchase of the lease, it is considered misrepresentation. An amendment to the law is timely to cater for a scheme that may address a different legal status of the purchaser. Australia introduced a certificate of lease to enhance the security of tenure.
Keywords:: Private Lease Scheme; Developer; Cetificate of lease; Misrepresentation.
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i17.2867
THE IMPACT OF TYPE 2 DIABETES ON THE CARDIOVASCULAR SYSTEM IN MALE AND FEMALE RATS
Authors: Ivanova Olha
Published: August 2021

Introduction. Type 2 diabetes mellitus is one of the main factors of the cardiovascular risk, which leads to a disproportionate increase in cardiovascular events in women and men. While the greater excess risk of diabetic vascular complications in women compared with men has been described, mechanisms underpinning the sex difference have not been identified in full. The aim of this study was to determine the impact of type 2 diabetes (T2D) on the functional state of the cardiovascular system in male and female rats. Materials and Methods. T2D was induced in male and female Wistar rats by a high-caloric diet during 14 weeks combined with intraperitoneal injections of 25 mg/kg streptozotocin twice per week. At the end of the study electrocardiograms were recorded in leads II. A comparative analysis of changes in the functional state of the heart in male and female rats with experimental T2D was conducted. Results. It was established that T2D, independently of gender, results in the formation of pathologically accelerated rhythm and sinus tachycardia in experimental animals. Experimental T2D led to the prolongation of the systole in rats of both sex and decreasing of R-wave voltage in males in comparison with control group. In addition, T2D was accompanied by multidirectional impact on the atrial function in the heart of both sexes: P wave’ amplitude was increased in females while it was decreased in males, what can indicate either right or left atrial enlargement. It was found that T2D promotes the development of myocardial diastolic dysfunction in females, in contrast to males, which was confirmed by prolongation of T-P interval and a decrease of amplitude and duration of the T wave in comparison with intact female rats. Conclusions. T2D, independently of gender, caused cardiac arrhythmias, functional changes in atrial and ventricular conduction, but only in females, in contrast to males, was accompanied by the development of myocardial diastolic dysfunction. This data justify the necessity of personalized- and gender-specific therapy development for the prevention and management of diabetic cardiovascular complications.
Projeções, fantasias e relações sociais
Authors: Francolin Trento Ana Clara , Quirino de Paula Laiany Maiara , Rocha Mauro Sérgio da , Gomes Luiz Rafaela
Published: August 2021

Este trabalho teve como objetivo refletir acerca da pornografia, considerando-a um tema que, apesar de pouco debatido, mostra-se relevante para discussão no campo da psicologia. A partir de uma revisão bibliográfica, foram identificados materiais científicos que apresentam interpretações simbólicas sobre a temática, dentro da perspectiva da psicologia analítica e do método construtivo proposto por Jung. A pornografia é permeada de diferentes representações e modificou-se ao longo dos anos conforme o contexto histórico-cultural, apresentando-se como símbolo de conteúdos da psique individual e coletiva. Com base na teoria da psicologia analítica, abordou-se a relação da pornografia com o inconsciente coletivo e com os conteúdos psíquicos, associando-a aos mitos, fantasias, projeções e relações sociais. Vale destacar que o artigo tratou do tema a partir de um olhar que o relaciona aos processos clínicos, trazendo à tona a sexualidade do sujeito e sua relação com os conteúdos psíquicos, e que não se teve a intenção de propor posicionamentos morais.
Hormonal and neuroendocrine control of reproductive function in teleost fish.
Authors: Rodríguez Gabilondo Adrian , Hernández Pérez Liz , Martínez Rodríguez Rebeca
Published: August 2021

Reproduction is one of the important physiological events for the maintenance of the species. Hormonal and neuroendocrine regulation of teleost requires multiple and complex interactions along the hypothalamic-pituitary-gonad (HPG) axis. Within this axis, gonadotropin-releasing hormone (GnRH) regulates the synthesis and release of gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Steroidogenesis drives reproduction function in which the development and differentiation of gonads. In recent years, new neuropeptides have become the focus of reproductive physiology research as they are involved in the different regulatory mechanisms of these species' growth, metabolism, and reproduction. However, especially in fish, the role of these neuropeptides in the control of reproductive function is not well studied. The study of hormonal and neuroendocrine events that regulate reproduction is crucial for the development and success of aquaculture.
Infección metastásica por Staphylococcus aureus en neonatos: a propósito de un caso
Authors: Taylor Laura , Mamani-García Carlos S. , Gutiérrez-Pingo Alexandra , Benites-Meza Jerry K. , Chambergo-Michilot Diego , Gálvez-Díaz Norma del Carmen , Barboza Joshuan J.
Published: August 2021

Metastatic infection as an infrequent complication of Staphylococcus aureus bacteremia in neonates is challenging due to the limited literature. To report the clinical case of a premature neonate who developed a metastatic infection as a complication of S. aureus bacteremia. We present the case of a premature neonate admitted to the Neonatal Intensive Care Unit, diagnosed with bacterial sepsis, neonatal respiratory distress syndrome, and involvement by premature rupture of the membrane. A patch catheter was inserted, and he was successfully treated for E. coli bacteremia. He was re-admitted for late sepsis due to infection with multi-sensitive S. aureus in a patch catheter. An abscess appears on the front of the chest due to S. aureus, confirming metastatic infection. The abscess was drained with a favorable resolution of the clinical picture. In neonates submitted to invasive procedures, it is essential to monitor the clinical evolution and early identification of metastatic infection after Staphylococcus aureus bacteremia and provide early treatment to avoid sequelae.
Experiencias en el uso de energía renovable en la República del Ecuador
Authors: Gómez-Assan Julio , Ajila-Freire Rosa
Published: August 2021

La tendencia a nivel mundial es utilizar energía renovable para depender menos de los combustibles fósiles y a su vez minimizar la contaminación ambiental, el Ecuador y sus gobiernos han realizado esfuerzos para generar este tipo de energía para contribuir a la matriz productiva del mismo. El objetivo de este estudio es determinar los proyectos y cambios que ha tenido la producción tanto de energía primaria como de energía renovable durante los años 2008 y 2018. El estudio se lo realizó a nivel mundial y de país; en lo que respecta al país se identificó experiencias del uso de energías renovables, se recopilaron datos para su respectivo análisis a nivel internacional y nacional, nos centramos en las principales obras de energía renovable funcionando y en proyectos dentro del proceso transformador de la matriz productiva energética del Ecuador. Para la elaboración de esta revisión bibliográfica se recopilaron artículos, folletos, libros pertinentes y relevantes publicados en los últimos 10 años. Se eligieron fuentes con datos originales y se descartó las que dependían de éstas. En el ámbito ecuatoriano, se determinó el valor del kilovatio instalado según la fuente de energía, su capacidad instalada y la energía producida. No hemos avanzado en proyectos de energía maremotriz y geotérmica.
Tecnología IgY: Estrategia en el tratamiento de enfermedades infecciosas humanas
Authors: Cruz, Tipantiza Nathaly , Torres, Arias Marbel
Published: August 2021

La aparición de microorganismos resistentes a antibióticos, el descubrimiento de nuevos agentes patógenos con potencial pandémico y el aumento de una población inmunocomprometida han dejado casi obsoleta la terapia antimicrobiana, terapia comúnmente usada para tratar enfermedades infecciosas. Por otro lado, las investigaciones acerca del uso del anticuerpo IgY para desarrollar inmunidad pasiva han demostrado el potencial que tiene la tecnología IgY para tratar enfermedades infecciosas víricas y bacterianas. Donde los anticuerpos IgY de aves se destacan por su alta especificidad, rendimiento y escalabilidad de producción a menor costo, con relación a los anticuerpos IgG de mamíferos. El objetivo de esta revisión es determinar la importancia del uso de los anticuerpos IgY como tratamiento terapéutico y profiláctico frente a los patógenos causantes de infecciones virales y bacterianas en humanos, mediante la recopilación de ensayos clínicos, productos comerciales y patentes registradas en el período de 2010-2021. Finalmente, con este estudio se estableció que la tecnología IgY es una herramienta biotecnológica versátil y eficaz para tratar y prevenir enfermedades infecciosas, al reducir los síntomas y la carga del patógeno.