bluuebunny/crossref_metadata_2025 huggingface dataset:
Mutations in 23S rRNA gene associated with clarithromycin resistance in Helicobacter pylori clinical isolates from Saint-Petersburg
Authors: Starkova Daria A. , Gladyshev N.S. , Polev D.E. , Egorova Svetlana A. , Svarval A.V.
Published: January 2025

Objective.
To identify point mutations in 23S rRNA gene associated with phenotypic drug resistance to clarithromycin (CLR) in clinical isolates of H. pylori.

Materials and Methods.
A total of 50 H. pylori clinical isolates (2014–2022) from adult patients with chronic gastritis (n = 32), duodenal ulcer (n = 11) and gastric cancer (n = 1) were included in this study. Of 50 isolates, 30 were obtained from newly diagnosed patients, 20 – from previously treated patients after eradication failure. All isolates were cultured on supplemented Columbia agar and incubated under microaerophilic conditions (GasPak 100). Antibiotic susceptibility testing was performed by disc diffusion method. The PCR products (1402 bp) of the 23S rRNA gene were sequenced by Sanger approach. The DNA sequences were compared to the H. pylori 26695 reference using Unipro UGENE v.38.1.

Results.
A total of 30 H. pylori isolates were determined as CLR-resistant and 20 isolates as CLR-susceptible. The A2147G point mutation was detected in 17 (56,7%) CLR-resistant isolates and one (5.0%) CLR-sensitive isolate (p = 0,0002). The other point mutation A2146G was found exclusively in 13.3% (4⁄30) of CLR-resistant isolates (p = 0,14). None of the CLR-resistant isolates carried two A2146G/A2147G mutations simultaneously, whereas 9 (30.0%) had neither of them. The agreement between genotypic and phenotypic susceptibility to CLR based on both A2146G + A2147G mutations was 70.0%. All clinical isolates obtained from previously treated patients (n = 20) were assigned to CLR-resistant group. Of these, 16 (80.0%) carried either A2146G or A2147G mutations, while among newly diagnosed patients (n = 30) only 5 isolates (16.7%) had one of two mutations (p = 0,003). The other point mutations out of 2146–2147 positions identified were G1567T, C1568A/T, A1825G, G1830A, T1834C, T2186C, but with no association with phenotypic drug resistance (p > 0.05).

Conclusions.
Our study showed that among all variants of nucleotide substitutions in 23S rRNA gene, the only one (A2147G) is significantly associated with phenotypic resistance of H. pylori to CLR. Despite the low frequency of A2146G point mutation, combination of A2146G/A2147G mutations can be used as a predictor of phenotypic resistance of Russian H. pylori clinical isolates.
Asociación entre Grupos Etarios Maternos y la Incidencia de Preeclampsia Severa y Eclampsia.
Authors: Castro Claros Osvaldo Marcelo
Published: January 2025

Introducción: Los controles prenatales son esenciales para identificar complicaciones como preeclampsia y eclampsia, responsables del 10 % de muertes maternas globales. En Bolivia, la información es limitada, especialmente en Cochabamba, donde falta investigación sobre su prevalencia e influencia de la edad materna. Este estudio analiza la asociación entre grupos etarios y estas complicaciones en controles prenatales de 2023. Metodología: Este estudio transversal utilizó datos secundarios del SNIS (2023) de Cochabamba, analizando la relación entre edad materna y preeclampsia severa/eclampsia. Incluyó registros completos de controles prenatales, clasificando la edad en cuatro grupos. Se emplearon análisis descriptivos y pruebas de Chi-cuadrado (p<0.05). Respetando principios éticos, los datos fueron anonimizados y aprobados por un comité ético local. Resultados: En 2023, Cochabamba registró 41,541 controles prenatales: 0.53 % en mujeres de 10-14 años, 12.34 % en 15-19 años, 68.83 % en 20-39 años y 18.30 % en 40-49 años. La preeclampsia severa afectó al 0.83 % y la eclampsia al 0.02 %. No hubo asociación significativa entre edad y preeclampsia (p=0.1100), pero sí con eclampsia (p=0.0024). Discusión: Los resultados confirman una incidencia del 0.83 % de preeclampsia severa y 0.02 % de eclampsia en Cochabamba durante 2023. Aunque no hubo asociación significativa entre edad y preeclampsia, sí con eclampsia (p<0.05), destacando el mayor riesgo en adolescentes y mujeres mayores de 40 años. Se recomienda fortalecer controles prenatales, capacitar personal médico y considerar factores sociales para mejorar los resultados.
IMPLEMENTASI TEKNOLOGI MESIN PRODUKSI OLAHAN ABON IKAN BANDENG KELOMPOK PKK DESA MBAWI
Authors: Idrus Yuliadi , Hermanto Koko , Dery Sofya Noura , Dzil Ikram Fadhli , Bahtiar Syamsul , Anggara Mietra , Munandar Imam , Ekastini Ekastini , Ali Topan Paris , Aldrin  , Suhaimi Lalu , Hadi Mukhtar , Nuryadi Halid , Robbani Farisan
Published: January 2025

Pada umumnya abon ikan biasanya diproduksi secara manual dengan proses dibuat dari suwiran dan penirisan minyaknya kurang efisien. Pentingnya teknologi tepat guna tersebut diharapkan bisa meningkatkan kualitas dan kuantitas produksi makanan olahan ikan bandeng. Program penerapan teknologi tepat guna diharapkan menghasilkan produksi ikan bandeng meningkat dan pendapatan. Metode yang dilakukan adalah pengembangan teknologi produksi olahan ikan bandeng yang dimulai dari mengindentifikasi kebutuhan mitra terkait operasional produksinya, merancang dan membuat mesin, melakukan pengujian terhadap mesin yang dibuat, melakukan pelatihan dan pendampingan kepada kelompok PKK Desa Mbawi. Hasil kegiatan ini yaitu dapat membantu kreativitas dan inovaasi olahan ikan bandeng menjadi olahan abon secara efektif dan efisien, sehingga dapat meningkatkan kesejahteraan dan pendapatan kelompok PKK Desa Mbawi.
SOSIALISASI DAN SIMULASI LANGKAH MITIGASI BENCANA GEMPA BUMI DI SMK NEGERI 1 BATUKLIANG
Authors: Ulfah,S.Si., M.Si Syarifatul , Rukayah  , Ahadi Giatma Dwijuna , Syuhada Fahmi , Hidayatullah Muhammad
Published: January 2025

Pulau Lombok adalah salah satu pulau indah yang terletak di Provinsi NTB. Pulau Lombok pada Tahun 2018 - 2024 sangat sering terjadi gempa bumi. Gempa bumi adalah proses pergerakan atau guncangan yang disebabkan oleh sesar aktif. Namun, sampai saat ini belum ada ilmuan ataupun alat yang mampu memprediksi dengan pasti kapan gempa bumi itu akan terjadi. Gempa bumi di pulau lombok disebabkan oleh salah satu sesar aktif yakni sesar naik Flores, dimana sesar aktif tersebut dapat menimbulkam gempa bumi dengan kekuatan luar biasa. Pemaparan pada kegiatan ini mengenai terminologi bencana, jenis-jenis bencana, gempa bumi, langkah mitigasi dan contoh bangunan anti gempa bumi. Dari pemaparan materi dan proses simulasi berjalan lancar dan interaktif sesuai dengan target dari seluruh tim. Sehingga dari kegiatan ini dapat meminimalisir dampak yang akan ditimbulkan. Akan tetapi, hal terpenting adalah masukan kepada pihak sekolah terutama ditempat kegiatan ini yakni tentang rambu-rambu jalur evakuasi dan posisi-posisi aman dilingkungan sekolah untuk berdiri saat terjadi gempa bumi.
LEGAL DOCTRINES AS SOURCES OF LAW
Authors:   Chechen State University n. a. A. A. Kadyrov, Grozny, Russia, Ozdamirova Laura M. , Ulubaeva Amina S. ,   Grozny State Petroleum Technical University named after academician M.D. Millionshchikov
Published: January 2025

The article is devoted to the study of the role of legal doctrines as sources of law. The aim of the study is to identify the peculiarities of the influence of legal doctrines on the formation and development of the legal system, to determine the criteria for attributing scientific legal views to the sources of law and to analyze their interaction with other sources of law.
Within the framework of the research the following tasks were set: to define the concept and essence of legal doctrine, to classify legal doctrines on various grounds, to analyze their influence on law-making and law enforcement in different legal systems.
The results of the study show that legal doctrines, despite the lack of formal status of a source of law, have a significant impact on the formation of legal norms and their interpretation, especially in conditions of legal pluralism.
The scientific novelty of the work lies in the analysis of the role of legal doctrines in the conditions of digitalization and globalization, as well as in the proposal of criteria for assessing the impact of doctrines on law-making. The practical significance of the study consists in the possibility of using the identified patterns to improve law-making and law-enforcement activities, as well as to improve the quality of legal education.
INFORMATION TECHNOLOGY IN PUBLIC ADMINISTRATION
Authors:   ACADEMY OF CRYPTOGRAPHY TECHNIQUES, Hanoi city, Vietnam, Khiem Phan Xuan , Eskiev Musa A. ,   FGBOU VO “Chechen State University named after A. A. Kadyrov”, Khasieva Kheda A. ,   GGNTU named after academician M. D. Millionshchikov
Published: January 2025

With the continuous development of global science and technology, countries around the world are gradually becoming information-based countries. The continuous develop-ment of information technology has also led to the transformation of the traditional bureaucratic administrative management model into a new type of government management model. In addi-tion, people's access to information and knowledge is also inseparable from the popularization and promotion of information technology. The development of information technology not only affects the way our human society is managed, but also has a certain degree of influence on the way our society is managed. Starting from the point of view of the application of information technology in the model of public administration, this article discusses and analyzes the impact of information technology on the model of public administration in order to draw appropriate conclusions.
DEVELOPMENT AND MODERN PRACTICE OF EXCISE TAXATION IN RUSSIA
Authors:   North Ossetian State University named after K.L. Khetagurov, Russia, Vladikavkaz, Tokaeva Maria E.
Published: January 2025

Excise taxation can be attributed to the earliest forms of tax withdrawals, when the civilized contours of the tax system itself had not yet been formed.
In different historical periods, excise taxes were used to regulate commodity flows and had varying degrees of burden and methods of payment. Currently, excise taxes form the basis of key taxes, which together account for over 80% of tax exemptions.
The article gives a retrospective view of excise taxation, characterizes its features at the present stage of functioning of the tax system of the Russian Federation, and determines the place and role of excise taxes in the structure of state tax revenues.
Taking into account the fact that excise taxes are used by the state primarily as a tool for regulating the level of consumption of certain goods, it seems important to consider their role as such a regulator from the standpoint of efficiency.
ASSESSMENT OF INNOVATION ACTIVITY ON THE FORMATION OF FINANCIAL POTENTIAL FOR THE DEVELOPMENT AND IMPLEMENTATION OF ENVIRONMENTAL INNOVATIONS
Authors:   Chechen State University to A. A. Kadyrov, Grozny, Russia, Demilkhanova Bela A.
Published: January 2025

Modern economic development of any territory cannot be considered without the implementation of policies aimed at its sustainable development, which, in turn, cannot be achieved without environmental investments that stimulate “green” innovations. The relevance of solving the problems arising in this case increases due to the need to make early investments in those areas that will ensure the realization of the financial potential for the development and implementation of environmental innovations at the regional level.
In the article on the basis of methods of comparative analysis, groupings, expert evaluation, statistical and economic-mathematical methods the level of innovation activity in the formation of financial potential for the development and implementation of environmental innovations in the North Caucasian Federal District and its subjects is assessed, and effective factors for its increase are identified. The results of the assessment have shown that the average level of the studied innovation activity is observed in the North Caucasus Federal District. The change in its value is in direct correlation with the change in expenditures on innovation activities and the volume of environmental investments in fixed capital. Environmental investments in the Che-chen Republic determined the growth of environmental protection financing and contributed to a rapid increase in the innovation activity under study.
The assessment of innovation activity on the formation of financial potential for the devel-opment and implementation of environmental innovations allows us to take into account the most significant factors of its increase in the development of investment strategies of regions.
DEVELOPMENT OF CRITICAL THINKING AND INFORMATION LITERACY OF FUTURE SPECIALISTS OF CUSTOMS SERVICE
Authors:   Grozny State Petroleum Technical University named after academician M.D. Millionshchikov, Musayeva Marha Said-Magomedovna , Rasumovа Zarema Sh. ,   Chechen State University n. a. A. A. Kadyrov, Grozny, Russia
Published: January 2025

The article is devoted to the actual problem of formation of critical thinking and information literacy of future customs service specialists. The aim of the research is to determine the main directions and methodical approaches to the development of these competencies in the process of professional training. Within the framework of the work the tasks of analyzing existing educational programs, identifying gaps and developing recommendations to improve the educa-tional process were set.
The results indicate the need to integrate critical thinking skills and information literacy into all disciplines of the curriculum, as well as the use of active and interactive teaching meth-ods.
The practical significance of the study lies in the development of recommendations for teachers of customs academies and universities to optimize the educational process and training of highly qualified specialists who are able to work effectively in the conditions of information overload and constantly changing legislation. Scientific novelty of the work consists in the sys-tematization of methodological approaches to the formation of critical thinking and information literacy in future customs specialists.
INTERPERSONAL COMMUNICATION OF STUDENTS OF HIGHER PROFESSIONAL EDUCATIONAL INSTITUTIONS
Authors:   Stavropol State Pedagogical Institute, Budennovsk branch, Budennovsk, Russia, Zastrozhnaya Tatyana V. , Gaytamirova Satsita A. ,   The Chechen State University named after A.A. Kadyrov, Grozny, Russia, Adaev Abubakar I. ,   Kadyrov Chechen State University, Grozny, Russia
Published: January 2025

As the concept of quality education becomes more and more popular, interper-sonal communication skills in non-professional fields have also become a real problem that all students of higher professional educational institutions must face and solve. Understanding the characteristics of interpersonal relationships is the first step in solving the problem. In the con-text of today's era of building a harmonious society, the interpersonal relationships of students of higher professional educational institutions, an important and special group of students, are attracting more and more attention from society, and have also become one of the important topics in the research of students of higher professional institutions. This article discusses ways to improve students' interpersonal communication skills, analyzes the problems faced by stu-dents of higher professional institutions, as well as the problems they face in interpersonal com-munication.
THE BASIC PRINCIPLES OF INTERPERSONAL COMMUNICATION BETWEEN STUDENTS OF EDUCATIONAL INSTITUTIONS
Authors:   Chechen State University n. a. A. A. Kadyrov, Grozny, Russia, Yanarsayeva Khadizhat I. , Adaev Abubakar I. ,   Kadyrov Chechen State University, Grozny, Russia, Maigova Diana D. ,   Grozny State Petroleum Technical University named after academician M.D. Millionshchikov
Published: January 2025

Interpersonal communication is a process in which certain information is con-veyed to people through certain means of expression, such as language, text, or body movements. For a social person, communication is inseparable from life. Good communication contributes to the improvement of interpersonal relationships, the development of personal physical and mental health, and harmony in life. How can students improve their interpersonal communica-tion skills? The answer to this question will be offered in the article.
CROSS PLATFORM REPUTATION GENERATION SYSTEM BASED ON ASPECT-BASED SENTIMENT ANALYSIS
Authors: KUMAR T. RAVI KIRAN , CH. ABHINAYA  , C. AKHILA  , V. MITHIN RAJ  , K. RAJU
Published: January 2025

The active growth of Internet-based applications such as social networks and e-commerce websites leads people to generate a tremendous amount of opinions and reviews about products and services. Thus, it becomes very crucial to automatically process them. Over the last ten years, many systems have been proposed to generate and visualize reputation by mining textual and numerical reviews. However, they have neglected the fact that online reviews could be posted by malicious users that intend to affect the reputation of the target product. Besides, these systems provide an overall reputation value toward the entity and disregard generating reputation scores toward each aspect of the product. Therefore, we developed a system that incorporates spam filtering, review popularity, review posting time, and aspect-based sentiment analysis to generate accurate and reliable reputation values. The proposed model computes numerical reputation values for an entity and its aspects based on opinions collected from various platforms. Our proposed system also offers an advanced visualization tool that displays detailed information about its output. Experiment results conducted on multiple datasets collected from various platforms (Twitter, Facebook, Amazon) show the efficacy of the proposed system compared with state-of-the-art reputation generation systems. Machine learning is an important component of the growing field of data science. Through the use of statistical methods, different type of algorithms is trained to make classifications or predictions, and to uncover key insights in this project. These insights subsequently drive decision making within applications and businesses, ideally impacting key growth metrics. Machine learning algorithms build a model based on this project data, known as training data, in order to make predictions or decisions without being explicitly programmed to do so. Machine learning algorithms are used in a wide variety of datasets, where it is difficult or unfeasible to develop conventional algorithms to perform the needed tasks.
The Use of Persuasive Sentences in Copywriting
Authors:   Universitas Nasional Pasim, Christinawati Santy , Trimastuti Wahyu ,   Politeknik Padjajaran, Latifah Anita ,   Universitas Nasional Pasim, Alpina Bela ,   Universitas Nasional Pasim, Angelika Eka ,   Universitas Nasional Pasim
Published: January 2025

This research is about the use of persuasive sentences in copywriting. The purpose of this research is to identify the use of persuasive sentences in copywriting. The data used in this study were obtained by taking several examples of marketing posters for a product from several sales sources. The results show that persuasive sentences are widely used as a copywriting technique.
Novel Insights into the Pathophysiology of Coronary Slow Flow Phenomenon: The Role of Triglycerides-Glucose Index and Electrocardiogram Risk Score in Subclinical Atherosclerosis
Authors: Kusuma Singgih , Erwin Sukandi  , Taufik Indrajaya  , Ferry Usnizar  , Irfannuddin
Published: January 2025

Background: Coronary slow flow phenomenon (CSFP) is characterized by delayed distal coronary vessel opacification without significant epicardial coronary stenosis. The underlying mechanisms of CSFP remain unclear, but subclinical atherosclerosis is a likely contributor. This study investigated the relationship between the Triglycerides-Glucose Index (TyG), Electrocardiogram Risk Score (ERS), and carotid intima-media thickness (CIMT) in CSFP patients.
Methods: This cross-sectional study involved 31 patients diagnosed with CSFP at Dr. Mohammad Hoesin General Hospital Palembang. CSFP was determined based on coronary blood flow slowdown on angiography. Data collection included anamnesis, physical examination, laboratory tests, echocardiography, and CIMT measurement. Statistical analysis was performed using SPSS 27.
Results: The majority of CSFP patients were male (51.6%) with a mean age of 50.87 ± 13.94 years. Dyslipidemia was the most prevalent risk factor (77.4%), followed by hypertension (35.5%), smoking (22.6%), and diabetes mellitus (6.5%). Statistical analysis revealed significant positive correlations between TyG index and CIMT (r = 0.445, p = 0.012), and between ERS and CIMT (r = 0.476, p = 0.007).
Conclusion: TyG and ERS indices are positively correlated with CIMT in CSFP patients. These indices may be useful tools for cardiovascular risk evaluation and early identification of high-risk patients for subclinical atherosclerosis and potential CSFP.
Epidural Hematoma Volume and Glasgow Coma Scale Score: A Cross-Sectional Analysis of Head Injury Patient
Authors: Stefanus Satria Adi Dharma  , Erie Bambang Prijono Setyabudi Andar
Published: January 2025

Background: Epidural hematoma (EDH) is a common neurosurgical emergency with potentially life-threatening consequences. The Glasgow Coma Scale (GCS) is a widely used tool for assessing the severity of head injuries, but its correlation with EDH volume remains unclear. This study aimed to investigate the relationship between EDH volume and GCS score in head injury patients.
Methods: A retrospective cross-sectional analysis was conducted on 63 patients with head injuries and EDH admitted to a tertiary care hospital between 2021 and 2023. EDH volume was measured using computed tomography (CT) scans, and GCS scores were recorded upon admission. Statistical analysis was performed to assess the correlation between EDH volume and GCS score.
Results: The mean EDH volume was 30.5 ml (SD = 22.5), and the mean GCS score was 11.2 (SD = 3.8). A significant negative correlation was found between EDH volume and GCS score (r = -0.437, p < 0.001), indicating that larger EDH volumes were associated with lower GCS scores.
Conclusion: EDH volume is significantly correlated with GCS score in head injury patients. This finding underscores the importance of prompt diagnosis and surgical intervention for EDH, especially in patients with large hematomas and low GCS scores.
Tingkat Pengetahuan Pasien Prolanis Terkait Edukasi Dagusibu Menggunakan Media Leaflet di Klinik Gracia Ungaran
Authors: Luh Putu Mahatrianti Eningsari  , Soraya Novalisa Nindhi , Suzan Septiana  , Ristina Rahma Shinta Dewi  , Agitya Resti Erwiyani  , Istinatus Sunnah
Published: January 2025

Swamedikasi (pengobatan sendiri) didefinisikan sebagai pemilihan dan penggunaan obat-obatan oleh individu untuk mengobati penyakit yang dikenali sendiri atau gejala. Resiko perilaku swamedikasi akan muncul jika dilakukan dengan tidak tepat. Salah satu penyebab ketidaktepatan tersebut dapat dikarenakan kesalahan DAGUSIBU. Penyampaian informasi tentang DAGUSIBU dapat dilakukan menggunakan leaflet. Tujuan penelitian ini untuk mengetahui pengaruh media leaflet pada pelaksanaan penyuluhan DAGUSIBU. Metode yang digunakan adalah metode penelitian pre eksperimental dengan rancangan one group pre and post test design. Teknik sampel yang digunakan peneliti jenis purposive sampling. Hasil penelitian ini didapatkan nilai rata-rata peningkatan pengetahuan peserta sebesar 14,77%.
Strategi Peningkatan Mutu dan Umur Simpan Produk Tahu di Desa Kalikidang Melalui Penerapan Teknologi Pasteurisasi
Authors: Ajeng Dyah Kurniawati  , Adanti Wido Paramadini  , Silvia Van Marsally  , Fitranaya Arlian  , Muhammad Tata Awaludin
Published: January 2025

Desa Kalikidang, Kecamatan Sokaraja adalah salah satu sentra produksi tahu yang ada di Kabupaten Banyumas. Salah satu permasalahan yang dihadapi oleh pengrajin tahu yang tergabung dalam Kelompok UMKM di Desa Kalikidang yaitu dalam proses distribusi dan pemasaran produk tahu ke konsumen seringkali ditemui terjadinya penurunan mutu berupa perubahan tekstur dan aroma pada produk tahu yang mengakibatkan produk menjadi tidak laku di pasaran. Kegiatan Pengabdian Kepada Masyarakat (PKM) ini bertujuan untuk meningkatkan mutu dan umur simpan pada produk tahu di Desa Kalikidang melalui penerapan teknologi pasteurisasi uap. Hasil   Kegiatan  Pengabdian  Kepada  Masyarakat  dalam  bentuk  penerapan teknologi tepat guna berupa proses pasteurisasi pada produk tahu memiliki dampak yang positif terhadap peningkatan mutu dan umur simpan dari produk tahu yang diproduksi oleh para pengrajin tahu di desa Kalikidang.
Pemberdayaan Pelatihan Pembuatan Makanan Tambahan bagi Ibu sebagai Upaya Pencegahan Balita Stunting di Kec. Sutojayan, Kab. Blitar, Jawa Timur
Authors: Anjani Nur Ilahi Anjani , Hanifiya Samha Wardhani  , Christine Indrawati  , Yuniarti Arbain  , Dwidia Mertasari  , Inensa Khoirul Harahap
Published: January 2025

Stunting merupakan masalah kesehatan global yang dapat menyebabkan rendahnya produktivitas Sumber Daya Manusia suatu negara. Masyarakat di Kecamatan Sutojayan, Blitar termasuk dalam kategori sosial menengah ke bawah yang mana asupan gizi kurang menjadi perhatian khusus, sehingga menyebabkan kejadian stunting. Tujuan penelitian  ini yaitu untuk meningkatkan pengetahuan Ibu terkait gizi  seimbang dan pelatihan pembuatan makanan tambahan sebagai upaya pencegahan balita stunting. Kegiatan ini dilakukan menggunakan metode pelatihan yang  dilaksanakan pada bulan 11-12 Juli 2024 di Kecamatan Sutojayan, Kabupaten Blitar. Kegiatan ini melibatkan tim PKM UNESA dan peserta PKM sebanyak 47 Ibu. Tahapan pelaksanaan kegiatan terdiri dari pemberian pre-test, pemaparan materi, diskusi dan tanya jawab, pemberian angket, serta post-test. Hasil kegiatan menunjukkan bahwa pelatihan pembuatan makanan tambahan sebagai upaya pencegahan balita stunting ini berhasil dan efektif dalam meningkatkan pengetahuan peserta dengan terpenuhinya indikator keberhasilan kegiatan yaitu kenaikan nilai pengetahuan lebih dari 5% pada lebih dari setengah peserta pelatihan yaitu sebanyak 24(51,06%) peserta.
Optimalisasi Kesejahteraan Masyarakat Desa Balas Klumprik: Pemberdayaan Masyarakat melalui Kreasi Alat Olahraga Ramah lingkungan dari Bahan Daur Ulang
Authors: Nur Ilahi Anjani  , Rizky Patria Nevangga  , I Made Wijaya  , Sri Dwiyanti
Published: January 2025

Masyarakat Desa Balas Klumprik menghadapi sejumlah permasalahan yang berkaitan dengan aksesibilitas, pemahaman akan kebugaran serta permasalahan sampah yang cukup serius. Penyuluhan dan pelatihan mengenai pembuatan alat olahraga dari daur ulang sampah merupakan salah satu solusi untuk mengatasi permasalahan tersebut. Kegiatan pengabdian dilaksanakan selama 3 bulan, Juni-Agustus 2024 yang bertempat di Desa Balas Klumprik dengan target 30 peserta. Instrumen kegiatan adalah nilai pre-test dan post-test dengan indikator keberhasilan >50% peserta mendapatkan peningkatan poin minimal 5%. Kegiatan pengabdian ini berhasil memenuhi indikator keberhasilan kegiatan, yaitu sebanyak 23 peserta (77%) mengalami peningkatan pengetahuan ≥5 point. Kegiatan pengabdian yang telah dilakukan terbukti berhasil dan efektif untuk meningkatkan pengetahuan peserta.
Penangkaran Kunang-Kunang Sebagai Konservasi Berbasis Masyarakat Di Desa Jladri
Authors: Jati Sumarah  , Dimas Aditia Firmansya  , Sotya Partiwi Ediwidjojo  , Wenny Marlini  , Ajeng Tiara Wulandari  , Ari Waluyo  , Laelil Rachma Fadhila  , Intan Nur Azizah  , M. Haikal Ramdani  , Duke Sabella  , Dewi Septian Endang Rahmawati  , Agustina Ananda Pratiwi  , Dwi Khoirul Anam  , Imam Maulana  , Syifa Nur Afiatun Khoiriyah
Published: January 2025

Penurunan populasi kunang-kunang di Indonesia, termasuk di Desa Jladri, disebabkan oleh faktor-faktor seperti perubahan habitat, pencemaran cahaya, dan konversi lahan. Kunang-kunang memiliki peran penting dalam ekosistem sebagai bioindikator kualitas lingkungan dan polinator alami. Untuk itu, diperlukan upaya konservasi yang melibatkan masyarakat sebagai aktor utama dalam pelestarian spesies ini. Pengabdian ini bertujuan untuk membangun penangkaran kunang-kunang di Desa Jladri sebagai bagian dari upaya konservasi berbasis masyarakat. Pengabdian akan mencakup pembentukan penangkaran kunang-kunang dengan menciptakan dan merawat habitat alami yang mendukung kelangsungan hidup kunang-kunang, serta pelatihan kepada masyarakat mengenai pengelolaan lingkungan dan pengurangan pencemaran cahaya. Dengan melibatkan masyarakat dalam setiap tahap kegiatan, diharapkan mereka dapat memiliki rasa kepemilikan yang tinggi terhadap pelestarian kunang-kunang.
Implementasi Pembinaan dan Pengawasan Untuk Meningkatkan Kapasitas Pengetahuan Industri Kecil Menengah di Kota Surabaya
Authors: Nafisa Shella Alfiani , Nurjanti Takarini
Published: January 2025

Pembinaan dan pengawasan merupakan salah satu program kerja bidang industri yang mencakup informasi mengenai evaluasi, catatan kepatuhan, dan rekomendasi perbaikan bagi industri yang telah dibina atau diawasi. Penelitian ini bertujuan untuk menganalisis pelaksanaan dan efektivitas dalam penerapan program pembinaan dan pengawasan pada Industri Kecil Menengah di Kota Surabaya. Data dianalisis menggunakan metode kualitatif dan pendekatan deskriptif dengan menggunakan teknik wawancara. Hasil dari wawancara mengungkapkan bahwa program mempunyai efektivitas dalam meningkatkan pemahaman IKM terkait perizinan usaha dan standar industri. Namun, terdapat juga hambatan dari pihak penyelenggara berupa keterbatasan sumber daya manusia dan perbedaan kesepahaman pada pihak penerima manfaat. Hasil penelitian menunjukkan bahwa diperlukannya upaya sinergis antara Dinas Perindustrian dan Tenaga Kerja dan pelaku IKM untuk meningkatkan efektivitas program pembinaan dan pengawasan untuk lebih meningkatkan minat IKM dalam mematuhi segala regulasi yang ada.
“Bimbingan Belajar” Peningkatan Literasi Siswa sebagai program kerja mahasiswa Universitas Hamzanwadi di SDN 2 Masbagik Timur
Authors: Uswatun Hasanah  , Ulpatul Laeli  , Shelly Alviani Utami  , Ilma Karmila  , Moh Yudi Nursyaid  , Muhammad Husnan  , Dina Apriana
Published: January 2025

Pendidikan merupakan fondasi utama untuk meningkatkan kesejahteraan masyarakat, yang berperan dalam mendorong pengembangan pengetahuan dan keterampilan individu untuk berkontribusi dalam kehidupan bermasyarakat. Melalui program KKN Bina Desa berbasis SDGs, khususnya pada tujuan ke-4 yaitu pendidikan berkualitas, mahasiswa Universitas Hamzanwadi dari program studi kependidikan berupaya berkontribusi melalui program kerja bimbingan belajar (bimbel) literasi dan numerasi. Observasi dan wawancara dengan guru menunjukkan adanya siswa di kelas 3, 4, dan 5 yang mengalami kesulitan belajar, terutama dalam membaca dan menulis. Program bimbel ini berfokus pada peningkatan kemampuan membaca siswa serta membangun motivasi mereka untuk terus belajar. Pendekatan personal melalui metode privat digunakan untuk menemukan strategi yang efektif. Hasil kegiatan menunjukkan adanya peningkatan signifikan dalam antusiasme belajar siswa bimbingan. Selain itu, kegiatan Sabtu Budaya dimanfaatkan untuk memperkaya literasi siswa melalui pemutaran video edukasi. Kolaborasi dengan guru serta penerapan metode yang adaptif menjadi faktor utama keberhasilan program ini dalam memberikan dampak positif terhadap siswa.
Upaya Peningkatan Status Kesehatan Bagi Siswa di Sekolah Indonesia Jeddah Melalui Pemeriksaan Kesehatan Gratis dan Penyuluhan Reproduksi Remaja
Authors: Endang Sri Wahjuni  , Anjani Nur Ilahi Anjani , Abdul Fauzi  , Satria Eureka Nurseskasatmata  , Nidya Comdeca Nurvitriana  , Fedelita Aistania Putri  , Sherly Aurellia Ardyananda  , Agatha Rachel Kristilla
Published: January 2025

Kesehatan reproduksi remaja menjadi perhatian global, dengan 33% beban penyakit perempuan terkait kesehatan reproduksi (WHO, 2010). Di Indonesia, prevalensi keputihan pada remaja perempuan mencapai 18% (SDKI, 2012), diperparah oleh akses terbatas terhadap informasi yang benar. Kondisi ini juga dialami siswa Sekolah Indonesia Jeddah (SIJ) yang membutuhkan edukasi kesehatan reproduksi dan pemeriksaan kesehatan reguler. Program pengabdian ini mencakup pemeriksaan kesehatan siswa TK-SD dan penyuluhan reproduksi remaja bagi siswa SMP-SMA. Penyuluhan dilakukan secara daring dengan pendekatan interaktif, menghasilkan peningkatan pengetahuan sebesar 20,5 poin (pre-test 65,7 menjadi post-test 86,2). Pemeriksaan kesehatan siswa TK-SD menemukan sebagian besar dalam status gizi normal, namun terdapat kasus obesitas dan gizi kurang. Program ini berhasil meningkatkan pemahaman siswa tentang kesehatan reproduksi dan mendukung lingkungan belajar sehat. Keberlanjutan program diharapkan melalui kolaborasi SIJ dan Universitas Negeri Surabaya secara berkala.
Sodium alginate/κ-carrageenan films for mupirocin dermal delivery
Authors: de Sousa Tamara Rodrigues , de Santana Sayza Dias , Cavallini Grasiele Soares , de Souza Nelson Luis Gonçalves Dias
Published: January 2025

Aim: The chronicity of injuries is also a public health problem, and it is necessary to develop and apply new materials to promote more satisfactory results in the wound healing. Thus, this study aims to develop natural polymer films based on a combination of κ-carrageenan and sodium alginate, crosslinked with Zn2+, for the controlled delivery of mupirocin (MUP). Methods: Vibrational spectroscopy (Raman and infrared spectroscopies) was used to characterize the chemical structure and crosslinking process. Micro-Raman imaging and scanning electron microscopy were employed to observe the spatial distribution of the polymers and morphology of the samples, respectively. The uniformity (in terms of mass, thickness, and MUP concentration) of the films, MUP release kinetics, and their bactericidal activity were subjected to analysis. Results: The films exhibited good uniformity in terms of thickness, mass, and quantity of MUP. However, the percentage of antibiotics was lower than that added, indicating losses during the film production process. Swelling and release kinetic studies indicated good swelling capacity of the films and controlled drug delivery process. The antibacterial activity of the films was determined against Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and Pseudomonas aeruginosa using the zone of inhibition method. All films produced showed activity against the growth of these bacteria. Conclusions: The results illustrate the potential of employing κ-carrageenan and sodium alginate in the fabrication of polymeric films for the regulated release of MUP, with the aim of developing wound dressings that can improve wound healing outcomes.
Two cellular models for analyzing mitochondrial heteroplasmy
Authors: Hu Yaning , Jiang Lin , Liu Wen , Zhao Xingbo
Published: January 2025

Aim: Mitochondria are essential for brain development, and the presence of different mitochondrial types is called mitochondrial heteroplasmy. Mitochondrial dysfunction is a central aspect of many people’s neurological diseases. Heteroplasmy is commonly observed in eukaryotes due to mitochondrial genome (mtDNA) mutation, paternal leakage, mitochondria transplantation/mitotherapy, and somatic cell nuclear transfer (SCNT). In this study, we developed two novel approaches to construct mitochondrial heteroplasmy cellular models.
Methods: Model 1: the yak cell line (Bos grunniens) was transfected with p-eGFP-neo plasmid while mammary alveolar cell-T (MAC-T) cell line from cattle cells (Bos taurus) was stained with MitoTracker Deep Red FM. The yak cell line was used as recipient cells which fused with enucleated cattle cells. Model 2: The cattle cell line was stained with MitoTracker Green FM while yak cells were stained with MitoTracker Deep Red FM. Cattle cells were used as recipient cells which fused with enucleated yak cells. Following fusions, the single cells exhibiting dual positive fluorescence signals were sorted into 96-well plate by fluorescence-activated cell sorting. Confocal fluorescence examination confirmed that the cells with mitochondrial heteroplasmy were sorted.
Results: The two methods can generate a variety of mitochondrial heteroplasmy cells of interest which can aid in understanding the patterns and influencing factors underlying heteroplasmy changes.
Conclusions: The mitochondrial heteroplasmy cellular model contributes to managing heteroplasmy mitochondrial changes and preventing the development of mitochondrial declines.
The Influence Of Celebrity Endorsement, Brand Image And Online Customer Reviews On Purchasing Decisions For Erigo Products Online (Study On All Erigo Product Users In Indonesia)
Authors: Rizki Ikfina , Sukaris Sukaris
Published: January 2025

This study aims to analyze the influence of Celebrity Endorsement, Brand Image, and Online Customer Reviews on purchasing decisions for Erigo products online. The research employs a quantitative method with a causal approach, involving 102 respondents selected through the Incidental Sampling method. Data analysis was conducted using multiple linear regression to examine the effect of each independent variable on the dependent variable. The results indicate that all three variables—Celebrity Endorsement, Brand Image, and Online Customer Review—have a positive and significant effect on purchasing decisions. Collectively, the independent variables explain 47.3% of the variation in purchasing decisions, while the remaining percentage is influenced by other factors outside this study. These findings contribute theoretically to the development of digital marketing knowledge and provide practical implications for advancing local product marketing strategies.
PSSs Layout using Dandelion Optimization Approach
Authors: Abd-Elazim Sahar M.
Published: January 2025

This paper develops an optimal Power System Stabilizers (PSSs) design employing the Dandelion Optimization Algorithm (DOA) implemented in a multimachine system. The synthesizing of PSS parameters is shaped as DOA-addressed optimization matter. An objective equation invoked by eigenvalue, incorporating lightly damped electromechanical modes, damping ratio, and factor, is utilized for the PSS layout. The functioning of the suggested DOA-based PSSs (DOAPSS) is evaluated against Differential Evolution-based PSSs (DEPSS) under various running requirements and disturbances. The supremacy of the DOAPSS is validated across time-domain analysis, eigenvalues, and functioning indices, demonstrating its superiority over the DE approach.
Comments on School Education in Mathematics and Computer Science
Authors: Benecke Klaus
Published: January 2025

This work aims to improve problem-solving skills even for students and adults, who are not so interested in mathematics. This requires simple algorithms. The efficiency of these is not the focus of this work, as we assume that computers will continue to take over this computational work. We concentrate on important, flexible operations that are as universal as possible. In doing so, we rely on the object of the structured table. A structured table can represent a number of any type, but also texts and structured collections of text and numbers. This means that the focus is no longer only on individual data operations such as addition, multiplication, sine, root, etc., but also on mass data operations such as selecting (choosing), sorting, aggregating, restructuring, joining (merging tables), etc. The work clearly shows that these operations can also be used to develop new, simpler solutions for the problems now being dealt with at school. Simpler, more universal algorithms that can be programmed by anyone should be taught at school. The work on the data model o++o was strongly motivated by the Relational data model with its language SQL and the language CONVERT, which tried to extend the flat table model to hierarchical data structures.
РЕЗУЛЬТАТИ ВИЗНАЧЕННЯ КІНЕТИКИ ВОЛОГОВМІСТУ І ТЕМПЕРАТУРИ В М’ЯСІ ЗА КОНДУКТИВНОГО СУШІННЯ ІЗ СТИСНЕННЯМ
Authors: Скрипник В. О. , Пономаренко Б. Г.
Published: January 2025

Важливішими задачами сучасної харчової промисловості, зокрема у сушінні харчової сировини, є збереження харчової цінності готового продукту та зниження енергетичних витрат. Кондуктивне сушіння вирішує такі завдання, але наразі досліджено недостатньо, що призводить до значного дефіциту наукових даних. Попит на продукти харчування з тривалим терміном зберігання, включно із сушеним м’ясом, особливо зростає в Україні через перебої з електропостачанням, викликані війною з росією. Це збільшує актуальність досліджень у цій галузі. Попередні дослідження переважно зосереджувалися на визначенні та аналізі кінетики вологовмісту та температури м’яса під час кондуктивного сушіння м’яса та не враховували стиснення самого м’яса. Залишалося невивченим, як стиснення може впливати на процес виведення вологи зі структури м’яса. У статті представлені результати експериментального дослідження кондуктивного сушіння сирого м’яса товщиною 0,003 м, 0,005 м і 0,007 м в умовах двобічного підведення теплоти з температурою поверхонь нагрівання до 130°C за різної маси навантаження, що створювало надлишковий тиск пари у поверхневому шарі сировини. Авторами досліджено і визначено кінетику вологовмісту та температури в умовах стиснення з навантаженням, визначено раціональну товщину сировини, а якість готового продукту оцінювалась органолептичним способом за 5-бальною шкалою. Результати досліджень порівнювалися з даними попереднього дослідження, в якому вивчався цей процес без навантаження на нагрівальну поверхню, що були опубліковані раніше. У результаті було встановлено, що сушіння в умовах стиснення з навантаженням дає змогу значно скоротити тривалість процесу та зменшити витрату енергії, при цьому якість готового продукту залишається високою. Апроксимація експериментальних кінетик вологовмісту і температури дала змогу розробити аналітичні моделі процесу у вигляді модифікованих експонент, що враховують товщину дослідного зразка і масу навантаження.
ГЕМАНГІОМИ ЯК ПОТЕНЦІЙНІ УСКЛАДНЕННЯ БАБЕЗІОЗУ: МОРФОГІСТОЛОГІЧНИЙ АНАЛІЗ КЛІНІЧНИХ ВИПАДКІВ
Authors: Ліщук С. Г. , Ковальова О. М. , Добровольський В. А.
Published: January 2025

Гемангіома селезінки у собаки являє собою доброякісне новоутворення, що формується через неконтрольоване розростання кровоносних судин у тканинах органу. У статті наведено результати дослідження впливу бабезіозу на формування гемангіоми селезінки у собак, а також вивчення частоти виникнення цієї патології і факторів, що сприяють її розвитку. Проаналізовано морфологічні і гістологічні характеристики гемангіоми, патофізіологічні механізми її утворення, а також ризик-фактори та прогностичні маркери для покращення методів профілактики і ранньої діагностики захворювання. Загальний клінічний аналіз крові собак з гемангіомою селезінки виявив зниження рівнів еритроцитів та гемоглобіну, виражену тромбоцитопенію та лейкоцитоз. Зниження гемоглобіну та гематокриту вказує на розвиток гемолітичної анемії та є ознакою анемічного синдрому, що спричиняє морфологічні зміни та порушення роботи всіх органів і систем. Ультразвукове дослідження тварин виявило гіпоехогенне утворення округлої форми, з неоднорідною структурою, ознаками патологічного кровотоку та чіткими краями. Рентгенограма продемонструвала гіпоехогенну ділянку та збільшення селезінки з характерними змінами в тканинах. Гістологічне дослідження органу після проведеної спленектомії показало, що тканина селезінки містить множинні судини малого діаметру капілярного типу, які розміщуються в фіброзній стромі та утворюють сітку різної форми. Вся пухлина складається з ендотеліальних трубочок, що в диференціальній діагностиці допомагає відрізнити гемангіому від злоякісних новоутворень, як-от гемангіосаркома. Таким чином, доведено, що збільшення функціонального навантаження на селезінку може спричинити патологічні зміни, які сприяють утворенню доброякісних новоутворень, як-от гемангіома. Цей процес може бути пов’язаний з порушенням кровообігу, змінами в гемодинаміці, активацією ангіогену та тривалим впливом інфекцій, зокрема бабезіозу.
ВПЛИВ МІКРОДОБРИВ НА УРОЖАЙНІСТЬ ТА ЯКІСТЬ ВЕГЕТАТИВНОЇ МАСИ І КОРЕНЕВИЩА З КОРЕНЯМИ РОСЛИН ЕХІНАЦЕЇ ПУРПУРОВОЇ (ECHINACEA PURPUREA (L.) MOENCH.) В УМОВАХ ПРАВОБЕРЕЖНОГО ЛІСОСТЕПУ УКРАЇНИ
Authors: Овчарук В. І. , Падалко Т. О.
Published: January 2025

У статті за результатами наукових досліджень 2021–2023 рр. висвітлено сутність внесення мікроелементів та застосування їх в ґрунті, які мають однакову валентність і здатність частково змінюватися, тому важливим досягненням було визначення функції мікроелементів, а також безпечне застосування їх на рослинах ехінацеї пурпурової сортів «Чарівниця» і «Поліська красуня». Ґрунти Правобережного Лісостепу України бідні на мікроелементи, їхня кількість залежить від ступеня опідзоленості, механічного складу ґрунту і вмісту гумусу, який доволі низький – 1,97%. Підтверджено, що ехінацея пурпурова вимоглива до мікроелементів, таких як бор, цинк, мідь, марганець, молібден, кобальт, на протистояння до несприятливих погодних умов, вилягання і засухи. Встановлено, що мікроелементи відіграли важливу роль у формуванні врожаю рослин досліджуваної культури. Молібден з урожайністю вегетативної маси в середньому 687 г з посудини вище контрольного варіанта на 162 г, кореневищ з коренями – 598 – 135 г (отримали за результатами досліджень у сорту Чарівниця). Аналогічні показники за врожайністю кореневищ з коренями 578 г, що на 244 г вище контролю спостерігалися в сорту Поліська красуня. За хімічними показниками найвищий вміст етерної олії вегетативної маси 0,28% та цикорієвої кислоти 1,3% забезпечив сорт Чарівниця. Різниця між сортами була невеликою. Дослідження дають змогу дійти висновку, що в умовах Правобережного Лісостепу України можна вирощувати ехінацею пурпурову на ґрунтах, бідних на ці мікроелементи, що регулювало якість сировини шляхом їх внесення.
The importance of inclusion in early childhood education: a look at inclusive practices in municipal institutions to promote educational equity
Authors:   Universidade Alto Vale Rio do Peixe, Machado Santos Adelcio , Simão Vera Lúcia , Bayer Vilmar , Machado Marinês
Published: January 2025

This article seeks to explore the importance of inclusion in early childhood education, analyzing inclusive practices adopted in municipal institutions
as a way of promoting educational equity, through
a review of literature based on the data collection
process carried out in them. following databases:
ERIC, Google Scholar and SciELO. The investigation
included 10 studies that met the inclusion and exclusion criteria, as well as the scope of the article.
The literature review showed significant results related to inclusive practices in early childhood education in Brazilian municipalities. Firstly, it was observed that municipal institutions have increasingly
adopted more inclusive strategies and interventions
to satisfy children’s needs. A growing recognition
of the importance of educational equity from early
childhood has also been identified, with a renewed
focus on promoting educational environments that
respect and value the diversity of its children. This
review has some limitations that must be considered
when interpreting its results. A significant limitation
is the exclusive focus on information sources in the
Portuguese language, as the theme analyzed is in the
Brazilian context, which may result in a partial view
of the subject to the exclusion of studies published
in other languages. Furthermore, due to the nature
of bibliographical research, it was not possible to
include primary data or carry out statistical analyses. Therefore, the conclusions presented are based
mainly on the qualitative interpretation of the selected studies. Therefore, it is concluded that promoting
educational equity from early childhood education is
an inversion that must form part of the structure of
goals and objectives of Brazilian educational plans.