bluuebunny/crossref_metadata_2025 huggingface dataset:
Thrills and Regressions revisited – Welche Träume träumen wir im Zeitalter elektronischer Medien?
Authors: Günter Michael
Published: October 2024

Michael Balint entwickelte in seinem 1959 erschienenen Buch »Angstlust und Regression« die Überlegung, dass es zwei Reaktionsweisen gebe, mit denen Menschen auf die traumatische Entdeckung reagieren, dass es feste und unabhängige Objekte gibt: die Oknophilie und den Philobatismus. Der Autor stellt in dem Aufsatz dar, in welcher Weise die Abwehrposition des Philobatismus, der Beschäftigung mit den freundlichen Weiten, eng mit dem Aufkommen elektronischer Bildmedien zusammenhängt. Die »freundlichen Weiten« des Fernsehens und des Internet sprechen speziell Jugendliche stark an und bieten ihnen Erfahrungsräume jenseits einer zu eng und gefährlich empfundenen Objektbeziehung. Die Gefahren die in diesen imaginierten »freundlichen Weiten« lauern, das Auftauchen gefährlicher Objekte und die manchmal daraus resultierenden Katastrophen werden in der Arbeit anhand dreier Fallvignetten von jugendlichen Sexualstraftätern, deren Taten in engem Zusammenhang mit dem Internet standen, diskutiert.
Psychodynamische und klinische Aspekte der Geschwistererfahrung und deren Bedeutung in der psychotherapeutischen Behandlung
Authors: Adam-Lauterbach Dorothee
Published: October 2024

In dem Artikel werden psychoanalytisch orientierte konzeptuelle und entwicklungspsychologische Aspekte zur Psychodynamik der Geschwisterbeziehung dargestellt. Die erfahrene Geschwisterposition als ein strukturierendes Merkmal wird als ein intersubjektives psychisches Geschehen aufgezeigt. Sowohl mangelnde psychische Abgrenzung und als Gegenpol zu viel Distanz können einen negativen Einfluss auf die Persönlichkeits- und Identitätsentwicklung und auf die Fähigkeit zur Beziehungsregulierung haben. Darüber hinaus wird auf klinische Auswirkungen konfliktbesetzter Geschwisterbeziehungen und auf damit zusammenhängende Überlegungen für die psychotherapeutische Behandlung eingegangen.
Rezension
Authors: Reichmann Ingrid
Published: October 2024

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Der Vater und die Triangulierung des Kindes
Authors: Hopf Hans
Published: October 2024

Kinder brauchen den Vater zur Identifizierung und zur Triangulierung. Triangulierung meint den Bezug zu etwas Drittem. Mit Triangulierung ist allerdings nicht die soziale Dreierbeziehung, sondern eine intrapsychische Struktur gemeint. Eine gelungene Triangulierung ist entscheidend von der Fähigkeit einer Mutter abhängig, das Kind nicht als ihren alleinigen Besitz zu betrachten. Reife Triangulierung, Symbolisierung und Mentalisierung sind Kennzeichen von seelischer Gesundheit. Der Artikel beschreibt Voraussetzungen zur Triangulierung, aber auch unterschiedliche triadische Störungen.
Negative Capability und Rêverie in Zeiten einer Pandemie
Authors: Oswald Wolfgang
Published: October 2024

Nicht nur in Zeiten einer Pandemie ist die Fähigkeit gefragt, sich mit Nicht-Fassbarem, Nicht-Erwünschtem und Nicht-Erträglichem auseinandersetzen zu können. Wilfred R. Bion ermöglicht es uns, solche Fertigkeiten zu entwickeln: sowohl durch seine psychoanalytischen Konzepte als auch durch seine charakteristische Art zu schreiben und die so entstehenden Lernerfahrungen. Der Vortrag versucht eine Verknüpfung zweier zentraler Konzepte von Bion mit den Besonderheiten von Hypnosepsychotherapie und Trance. Ein Blick auf Bions Leben und seine Art die Welt zu sehen und sich damit auseinanderzusetzen soll das Verständnis seiner psychoanalytischen Konzepte erleichtern.
Mentalisieren und Katathym Imaginative Psychotherapie
Authors: Staun Lenka , Sabbioni Marzio
Published: October 2024

Das Mentalisierungskonzept wurde als Brückenkonzept zwischen der Bindungstheorie, der Entwicklungspsychologie und der Psychoanalyse entwickelt. Mentalisieren kann als die imaginative Fähigkeit beschrieben werden, das eigene Verhalten und das Verhalten anderer auf der Grundlage von psychischen Phänomenen implizit und explizit als sinnhaft zu verstehen. In der dynamischen Entwicklung des Mentalisierens entstehen Repräsentanzen, d.h. innere Bilder mit dazugehörigen Gedanken und Gefühlen, die im Rahmen eines reflexiven Prozesses bearbeitet werden. Es kommt dabei zur Bildung von Repräsentanzen von affektbesetzten inneren Vorstellungen, was den Symbolisierungsprozess aus der Sicht der Mentalisierung beschreibt. Bei der KIP steht die imaginative Funktion im Vordergrund des Interesses, die sich auf das Bild und den Primärprozess stützt und einen selbstreflexiven Prozess auslöst. Dies beschreibt den Symbolisierungsprozess aus Sicht der KIP, und wie aus Bildern katathyme Imaginationen werden. Das Mentalisieren und die Symbolisierungsfähigkeit unterliegen als strukturelle Eigenschaften einer Entwicklung und Reifung. Die einmal erreichte Mentalisierungsfähigkeit kann aber kontext- und bindungsspezifisch gestört werden, sodass prämentalisierende Modi wieder auftreten können. Das Mentalisierungskonzept erweist sich als hilfreich, um Situationen besser zu verstehen, die mit Störungen der Imaginationsfähigkeit einhergehen, und liefert Hinweise, wie therapeutisch mit einer mentalisierungsfördernden Haltung oder mentalsierungsbasierten Interventionen damit umgegangen werden kann.
Intersubjektivität – Psychotherapie als gemeinsame Erfahrung
Authors: Ermann Michael
Published: October 2024

Das Konzept der Transformation verweist auf das interpersonelle Feld, in dem unbewusste Austauschprozesse zwischen den Beteiligten stattfinden. Diese Prozesse stehen im Zentrum einer Betrachtungsweise, die sich in den letzten Jahrzehnten in der Psychoanalyse etabliert hat: Die Intersubjektivität. Sie rückt das Zusammenspiel zwischen den Subjektivitäten, d.h. die zwischenmenschliche Begegnung in den Vordergrund. Sie betrachtet die gegenseitige und wechselseitige Einflussnahme, die in jeder Begegnung unweigerlich zum Tragen kommt, als Motor für Veränderungen. Dieser Ansatz soll auf der Basis von klinisch-praktischen Erfahrungen Gegenstand dieses Beitrags sein. Dabei beschäftigt den Autor vor allem die Wirkung der therapeutischen Therapie, nämlich die Veränderung des Selbst der Beteiligten oder, in moderner Terminologie: die Transformation der Subjektivitäten.
Spaltungsmechanismen und der therapeutische Umgang mit Destruktivität
Authors: Brömmel Bernhard
Published: October 2024

Beschrieben wird das Konzept der Spaltung als der dominante Abwehrmechanismus struktureller Pathologie. Mit einem kurzen Blick auf die kollektive Situation im zweiten Jahr der Corona-Pandemie drängt sich in dem Zusammenhang die nähere Untersuchung narzisstischer Phänomene, die ja auf Spaltungsabwehr basieren, auf. Zum einen bieten sie einen Ansatz, aktuelle gesellschaftliche Konflikte zu verstehen, zum anderen stellen sie uns in der therapeutischen Arbeit vor große Herausforderungen. Ein übertragungsfokussiertes Arbeiten im Sinne Otto Kernbergs wird als hilfreiche und entscheidende Erweiterung der therapeutischer Möglichkeiten im Umgang mit destruktiven Übertragungen im Rahmen einer Katathym Imaginativen Psychotherapie vorgestellt. Eine Interpretation Friedrich Schillers Drama Maria Stuart ergänzt die klinischen Überlegungen.
Rezension
Authors: Hauler Barbara , Dieter Jadranka
Published: October 2024

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Familienbeziehungen im Lauf des Lebens
Authors: Kottje-Birnbacher Leonore
Published: October 2024

In diesem Beitrag geht es um die familiären Beziehungen in verschiedenen Lebensphasen, wie sie uns prägen und wie wir sie gestalten können. Eltern bieten ihren Kindern einen Entwicklungsraum mit sehr unterschiedlichen Angeboten an Fürsorge, Weltsicht und Identifikationsmöglichkeiten, Normen, Werten, Anforderungen und Unterstützungen. Durch die ständigen Wechselwirkungen von Angeboten und Reaktionen werden die Gefühle und das Verhalten der Kinder geprägt. Als Erwachsene suchen sie Partner, mit denen sie zusammenleben können. Es sind vielfältige Einigungsprozesse und Verarbeitung von Krisen und Enttäuschungen notwendig, bis aus einer Verliebtheit eine neue stabile Bindung entstanden ist. Später steht der Umgang mit alten Eltern an, mit Anpassung der inneren Bilder vom Selbst und vom Andern an die inzwischen gültige Realität mit Umkehrung der Machtverhältnisse: die Eltern sind nun bedürftig und nicht mehr machtvoll, und die erwachsenen Kinder mitten im Leben und in der Fürsorge-Pflicht.
An Hand von Fallbeispielen wird gezeigt, wie man durch die Analyse der familiären Interaktion und durch KB-Bilder den Patienten bisher nicht gesehene eigene Anteile an Schwierigkeiten aufzeigen kann, so dass sich differenziertere und realistischere Bilder vom Selbst und vom Andern entwickeln, die ein anderes Fühlen und Verhalten ermöglichen.
Verkörpertes Selbst und Zwischenleiblichkeit
Authors: Küchenhoff Joachim
Published: October 2024

Der Beitrag geht von zwei Leitbegriffen, dem »verkörperten Selbst« und der »Zwischenleiblichkeit« aus. Sie werden mit Hilfe des leibphilosophischen Ansatzes von Maurice Merleau-Ponty eingeführt. Anschließend wird ein dritter Begriff, »Transformationsarbeit«, genutzt und als Terminus technicus für die therapeutische Arbeit mit psychosomatisch erkrankten Menschen vorgeschlagen. Anhand von zwei Fallvignetten, die Menschen betreffen, die sich in ihren Möglichkeiten selbstständiger Transformation unterscheiden, die Transformationsarbeit in der Praxis vorgestellt werden. Das erste Beispiel wird sich mit der deutenden Arbeit am leiblichen Selbst befassen, das zweite mit der produktiven Nutzung der Zwischenleiblichkeit in der Behandlung schwerer psychosomatischer Leiden. Am Ende stehen zusammenfassende theoretische Anmerkungen zum Verhältnis von Zwischenleiblichkeit und Transformation.
Professional Port Police: Donald Cassidy’s 1967 Reports on Policing and Security in Canadian Commercial Ports
Authors: Madsen Chris
Published: October 2024

In response to a troubling rise in criminal activity in some of Canada’s major commercial seaports during the mid-1960s, the federal Department of Transport engaged a former Royal Canadian Mounted Police/Gendarmerie royale du Canada (RCMP/GRC) member seconded from the Dominion Bureau of Statistics to study the scope of the problem and suggest possible improvements. Two reports were prepared, an internal one for the government harbours board and a public one for the private association representing port managements. A key outcome was creation of the National Harbours Board Police, a new federal police force distinct from the RCMP/GRC. This commentary compares the reports with a table showing the principal recommendations.
En réponse à une augmentation inquiétante de l’activité criminelle dans certains des principaux ports maritimes commerciaux du Canada au milieu des années 1960, le ministère fédéral des Transports a engagé un ancien membre de la Royal Canadian Mounted Police/Gendarmerie royale du Canada (RCMP/GRC) détaché du Bureau fédéral des statistiques pour étudier l’ampleur du problème et suggérer des améliorations possibles. Deux rapports ont été préparés, l’un interne pour le conseil gouvernemental des ports et l’autre public pour l’association privée représentant les gestionnaires des ports. L’un des principaux résultats a été la création de la Police du Conseil national des ports, un nouveau corps de police fédéral distinct de la RCMP/GRC. Ce commentaire compare les rapports avec un tableau reprenant les principales recommandations.
Effect of Teaching Style on Academic Self-Concept in Mexican University Students of Physical Education: Multiple Mediation of Basic Psychological Needs and Motivation [Efecto del estilo docente sobre el autoconcepto académico en universitarios mexicanos de Educación Física: mediación múltiple de las necesidades psicológicas básicas y la motivación]

Authors: Espinoza-Gutiérrez Roberto , Baños Raul , Calleja-Núñez Juan José , Granero-Gallegos Antonio
Published: October 2024

The objectives were to analyze the psychometric properties of the adaptation of ASC and Interpersonal Teaching Style in Higher Education (ITSHE) scales, as well as to analyze the predictive effect of ITS on ASC, considering the multiple mediation of basic psychological need satisfaction (SBPN), basic psychological need frustration (FBPN), and academic motivation. Study 1 involved 357 subjects aged between 18 and 45 years. The psychometric properties of the ITS and ASC scales were analyzed. Study 2 involved,808 subjects aged between 18 and 45 years. Structural equation modeling was employed for the analysis. The ITSHE and ASC scales were found to be valid and reliable. SEM analysis revealed multiple mediation effects of SBPN and autonomous motivation between autonomy support and ASC, significantly increasing the total effects on ASC. The Autonomy-supportive style positively predicted SBPN, autonomous motivation, controlled motivation, and ASC, and negatively predicted FBPN and amotivation. Conversely, a controlling teaching style negatively predicted FBPN and amotivation. University students' ASC is enhanced when instructors support autonomy, thereby fostering SBPN and autonomous motivation.
Resumen
Este estudio tuvo por objetivo analizar las propiedades psicométricas de la adaptación de las escalas de Autoconcepto Académico (ASC) y Estilo Interpersonal Docente en Educación Superior (EIDES) en universitarios mexicanos, así como analizar el efecto predictivo del EIDES sobre el ASC, considerando la mediación múltiple de la Satisfacción De Necesidades Psicológicas Básicas (SNPB), la Frustración De Necesidades Psicológicas básicas (FNPB) y la motivación académica. En el estudio-1 participaron 357 sujetos de entre 18 y 45 años. Se analizaron las propiedades psicométricas de las escalas de EIDES y ASC. En el estudio-2 participaron, 808 sujetos de entre 18 y 45 años. Se empleó el modelado de ecuaciones estructurales para el análisis. Las escalas de EIDES y ASC resultaron ser válidas y fiables. El análisis de ecuaciones estructurales reveló efectos de mediación múltiple de la SNPB y la motivación autónoma entre el apoyo a la autonomía y el ASC, aumentando significativamente los efectos totales sobre el ASC. El estilo de apoyo a la autonomía predice positivamente la SNPB, la motivación autónoma, la motivación controlada y el ASC; y predice negativamente la FNPB y la desmotivación. Por el contrario, el estilo de enseñanza controlador predice negativamente la FNPB y la desmotivación.
Analysis of the Impact of an Emotional Development Program on Students with Attention Deficit Hyperactivity Disorder [Análisis del impacto de un Programa de desarrollo emocional en alumnado con Trastorno por Déficit de Atención e Hiperactividad]

Authors: Cabello-Sanz Sandra , González-Benito Ana , Muñoz-Parreño Julián Alfonso
Published: October 2024

A characteristic symptom of Attention Deficit Hyperactivity Disorder (ADHD) is difficulty in controlling emotions due to alterations in the prefrontal and amygdalar areas of the brain (Faraone et al., 2019). Objective: to design, implement, and evaluate the effectiveness of an Emotional Education Program in individuals with ADHD. Method: a quasi-experimental pretest/posttest design with two groups was used in a sample of 66 students aged 8 to 12 diagnosed with ADHD (37 in the experimental group and 29 in the control group). The Emotional Development Questionnaire (9-13) (CDE 9-13) (López-Cassà and Pérez-Escoda, 2009), the Emotional Competence Questionnaire for Primary Education (CCEEP), developed ad hoc for this research, and three questionnaires to assess satisfaction with the Program by students and their families (adapted from Álvarez González et al., 2011) and the implementer (Pérez-González, 2008) were used. Results: after the implementation of the Program, there was a significant improvement in emotional awareness, emotional regulation, emotional autonomy, social competence, life skills, and well-being, as well as in overall emotional competence. Conclusions: the Program has a positive impact on the emotional development of students with ADHD.
Resumen
Un síntoma característico del Trastorno por Déficit de Atención e Hiperactividad (TDAH) es la dificultad para controlar las emociones debido a alteraciones en la zona prefrontal y amigdalar del cerebro (Faraone et al., 2019). Objetivo: diseñar, implementar y evaluar la eficacia de un Programa de Educación Emocional en sujetos con TDAH. Método: se utilizó un diseño cuasiexperimental pretest/postest de dos grupos en una muestra de 66 estudiantes entre 8 a 12 años diagnosticados con TDAH (37 del grupo experimental y 29 del control). Se empleó el Cuestionario de Desarrollo Emocional (9-13) (CDE 9-13) (López-Cassà y Pérez-Escoda, 2009), el Cuestionario de Competencia Emocional para Educación Primaria (CCEEP), elaborado ad hoc para esta investigación y tres cuestionarios para evaluar la satisfacción con el Programa por parte del alumnado y sus familias (adaptado de Álvarez González et al., 2011) y de la persona implementadora (Pérez-González, 2008). Resultados: tras la implementación del Programa, se produjo una mejora significativa en conciencia emocional, regulación emocional, autonomía emocional, competencia social, competencias para la vida y el bienestar, así como en la competencia emocional total.  Conclusiones: el Programa tiene un impacto positivo en el desarrollo emocional del alumnado con TDAH.
Стратегія розвитку конкурентоспроможного регіону на основі його брендування
Authors:   Національний університет «Одеська політехніка», Забарна Елеонора
Published: October 2024

Основною метою дослідження є визначення основних практичних підходів до формування стратегії розвитку регіону на основі його брендування. У роботі доведено, що створення реальних засад стійкого соціально-економічного розвитку територій, добробут населення регіону має бути зосередженим на активному використанні власного потенціалу, ресурсів, специфіки та особливостей місцевості та унікальності самого регіону. Визначено, що стратегія регіонального розвитку має орієнтувати регіон на підвищення його конкурентоспроможності та виокремлення його особливостей серед інших на основі заходів маркетингу територій у контексті формування бренду кожного окремого регіону. На основі аналізу визначено, що створення ефективного бренду регіону дає можливість активізувати внутрішні особливості та резерви регіонального розвитку, стимулювати розвиток малого та середнього підприємництва в регіоні, формувати сприятливе середовище для залучення інвестицій в регіон. Представлено визначення маркетингу території в контексті створення бренду регіону. Виявлено складові дизайну регіону. Запропоновано основні маркетингові регіональні стратегії та основні етапи їх підготовки з урахуванням можливостей створення його бренду.
Глобальна кооперація в умовах конфліктів: емпіричне дослідження волатильності зовнішньої торгівлі в Україні та світі
Authors:   Київський національний економічний університет ім. Вадима Гетьмана, Котіна Ганна , Степура Марина ,   Київський національний економічний університет ім. Вадима Гетьмана, Котін Ілля ,   Київський національний економічний університет ім. Вадима Гетьмана
Published: October 2024

У статті розкрито проблематику глобальної кооперації в умовах конфліктів, надано тлумаченням міжнародної кооперації в сучасному світі та її архітектури, досліджено, як Україна долучена до неї з акцентом на торгівлю і капітал. Зазначено, що оскільки глобальна кооперація стосуються міжнародної політики та управління, постають виклики глобальних колективних дій. Підкреслено, що є велика диспропорція в глобальній співпраці, і наголошено, що скорочення розриву між більш і менш інтегрованими країнами може призвести до значних економічних вигід, але така реконфігурація тягне за собою додаткові компроміси. Зауважено, що сьогоднішній світ глибоко взаємопов'язаний. Відзначено, якщо бар'єри для торгівлі продовжуватимуть зростати, деякі країни можуть постраждати від уповільнення економічного зростання та зниження дифузії продуктивності та інновацій. Проаналізовано перенаправлення торговельних потоків у результаті російського вторгнення в Україну та його вплив на можливості розширення зовнішньоекономічної кооперації України.
Current mode of electrochemical 3D printing of copper parts
Authors:   Національний технічний університет України «Київський політехнічний інститут імені Ігоря Сікорського», Плясовська Антоніна , Ущаповський Дмитро ,   Національний технічний університет України «Київський політехнічний інститут імені Ігоря Сікорського», Лінючева Ольга ,   Національний технічний університет України «Київський політехнічний інститут імені Ігоря Сікорського», Воробйова Вікторія ,   Національний технічний університет України «Київський політехнічний інститут імені Ігоря Сікорського», Васильєв Георгій ,   Національний технічний університет України «Київський політехнічний інститут імені Ігоря Сікорського»
Published: October 2024

The peculiarities of the use of copper nitrate electrolytes in local electrodeposition or electrochemical 3D printing systems have been studied. A model of the current mode in electrochemical 3D printing has been proposed. The possibility of obtaining electrochemically 3D printed objects with a profile height up to 100 μm with a compact fine-crystalline metal structure at a current density of 2 A/dm2 in a copper nitrate electrolyte with a content of 300 g/l and with the simultaneous introduction of gloss-forming additives of the Rubin complex (KIESOW OBERFLÄCHENCHEMIE GmbH & Co) and glycine is shown.
Epidemiological and clinical aspects of syphilis incidence in the Russian Federation and the Kyrgyz Republic: comparative analysis
Authors: Rakhmatulina Margarita R. , Novoselova Elena Y. , Yusupova Dilara M. , Sadykova Dano A.
Published: October 2024

The Soviet period of development of domestic dermatovenereology was characterized by scientific achievements and the creation of organizational forms of combating venereal and contagious skin diseases. After the collapse of the USSR, socio-economic changes occurred in the former Soviet republics that affected the medical sphere. In recent years, cooperation in the exchange of experience between dermatovenereological services of Russia and other countries is actively developing, including in the field of prevention of the spread of STIs. In 2021 and 2022, a significant increase (by 69.7%) in the incidence of syphilis was registered in Russia for the first time compared to 2020, which is due to an increase in this indicator among migrants (from 2801 cases in 2020 to 12 748 cases in 2022), of which 30% of syphilis cases were among citizens of Kyrgyzstan. The article presents the results of a retrospective comparative study of syphilis incidence rates among children aged 0 to 14 years, adolescents aged 15 to 17 years, and adults over 18 years in the Russian Federation and the Kyrgyz Republic, and analyzes regulatory documents governing syphilis testing and treatment. Despite significant similarities in approaches to laboratory diagnostics of syphilis, uniform principles of prenatal examination of women and treatment of pregnant women, there are currently a number of significant differences, including in the lower percentage of CSF examination due to few indications for performing lumbar puncture, shorter courses of therapy and low doses of drugs, shorter periods of clinical and serological monitoring in the Kyrgyz Republic.
Internações e óbitos por infarto agudo do miocárdio no Estado do Maranhão
Authors: Oliveira Carolayne Queiroz de , Uchôa Yuri Coutinho , Barroso Wermerson Assunção , Braga Aécio Assunção
Published: October 2024

Objetivo: Analisar o panorama epidemiológico de internações e óbitos por infarto agudo do miocárdio no estado do Maranhão. Métodos: Trata-se de um estudo retrospectivo, analítico, observacional, transversal, de abordagem quantitativa, em que foi realizada a análise dos casos de infarto agudo do miocárdio registrados no sistema do DATASUS, através do CID-10. O local de estudo foi o estado do Maranhão, no período de janeiro de 2017 a dezembro de 2023, levando em consideração determinantes sociodemográficos como sexo, faixa etária, raça/cor e macrorregião de saúde. As informações obtidas foram tabuladas por meio do software Microsoft Excel versão 2019. Resultados: Registrou-se um total de 10611 internações, com maior prevalência no sexo masculino (62,09%), mas maior mortalidade nas mulheres (14,74%). A faixa etária 60-69 anos somou 3125 (29,45%) casos, com 382 (27,38%) óbitos, sendo a mais acometida. A raça parda liderou com 5423 (51,11%) hospitalizações registradas. A macrorregião norte destacou-se com 5873 (55,34%) internações e 706 (50,05%) mortes. Ao todo, o estado gastou R$ 21.672.960,63 com serviços destinados a essa razão. Conclusão: O estudo corrobora a importância da prevenção e promoção de saúde ao identificar fatores de risco na atenção primária, além da descentralização de serviços de saúde e oferta de atendimento especializado.
Impacto de uma intervenção educativa em primeiros socorros para gestantes e puérperas na prevenção da mortalidade infantil
Authors: Kalisiensky Ana Clara Ferreira , Caliman Brena Marcial , Tamanini Karoline Veronês , Carvalho Angélica Mota Alves de , Couto Bruna Alvarenga do , Meyrelles Bruna Barbosa , Freire Isabela Bernardino , Cotta Amanda Andreatta , Poton Wanêssa Lacerda
Published: October 2024

Objetivo: Avaliar o impacto da educação em primeiros socorros no manejo de acidentes domésticos. Métodos: Intervenção educativa randomizada realizada com 60 gestantes com mais de 28 semanas e puérperas com até 90 dias de pós-parto, de agosto de 2023 a junho de 2024, aplicada em uma única sessão educativa, precedida de um pré-teste. O mesmo teste foi aplicado para o grupo controle. Após seis meses, as mulheres, de ambos os grupos, foram entrevistadas sobre a ocorrência de acidentes. Análises foram realizadas no Programa Stata 16.0. Resultados: Mais de 80% das participantes não haviam recebido orientações sobre primeiros socorros. Metade já havia vivenciado alguma situação de risco com crianças e, dentre estas, metade não soube como proceder. Após o curso, o número de acertos no pós-teste aumentou em 36%. Seis meses após, o rendimento foi de 91%, 31% vivenciaram engasgo ou queda com crianças, 100% realizaram a conduta adequada e não houve desfecho grave. No grupo controle, 27% relataram queda ou engasgo, apenas metade soube intervir da maneira adequada e não tendo eventos fatais. Conclusão: O estudo denota o impacto positivo de uma intervenção de baixo custo e fácil implementação na redução de desfechos graves em caso de acidentes em crianças.
Formulation and Evaluation of Haemocoagulase Gel for Dental Pulp- an In-vitro study.
Authors: Karkare Swati . , Thosar Nilima . , Wagh Milind , Wagh Nikita
Published: October 2024

This study aims to develop a novel hemostatic gel of hemocoagulase, a snake venom-derived serine protease enzyme, by incorporating it into the matrix of bioadhesive polymers to prevent damage due to hemorrhage. Haemocoagulase was combined with polymers Carbopol 940 and HPMC K 100, and these formulations were evaluated for physical properties, efficacy, safety and stability. Batches F3 and F6 were selected for further studies on animal models, which were found to be safe without any skin irritation effect and effective as hemostats with blood clotting times of 1.24 ± 0.007 min and 1.36 ± 0.014 min, respectively, in a rat liver incision model. From this study, it can be suggested that the combination of hemocoagulase with bioadhesive polymer can provide a novel hemostatic tool for controlling bleeding.
In-vitro antidiabetic activity of ethanolic extract from Khla (Schumannianthus dichotomus Roxb.) rhizome.
Authors: Sudjaroen Yuttana . , Thongkao Kanittada . , Thongmuang Pimporn .
Published: October 2024

Schumannianthus dichotomus Roxb. in Thai, namely “Khla,” is notably distributed in South and South-East Asia regions. In Thai traditional medicine, rhizome has a bland taste, and after decoction, it is used to reduce body heat and fever and treatment of skin diseases. Recently, the methanolic extract of rhizome had reported the hepatoprotective and hypoglycemic activities in mice. Aims of this study were conducted to determine the nutritional value of rhizome and to evaluate α-glucosidase, and α-amylase inhibitory activities of ethanol extract from the rhizome (KE). The rhizome had a high content of dietary fiber and iron, while it was low in calories, fat, and carbohydrates. Thus, it can become an ingredient of a healthy diet. The total phenolic content of KE contained 229.8 ± 6.23 mg of gallic acid equivalent (GAE)/g. There was strongly inhibited α-glucosidase (IC50 = 0.11 ± 0.03 mg/mL) and comparable with the antidiabetic drug acarbose (IC50 = 0.10 ± 0.03 mg/mL). Therefore, KE was slightly inhibited by α-amylase (IC50 = 0.42 ± 0.05 mg/mL), when compared with acarbose (IC50 = 0.016 ± 0.001 mg/mL). Thus, the phytochemicals of different extracts are necessary to be identified. Therefore, the advance techniques were the limitation of our study.
Microemulsion Drug Delivery of Anti-malarial.
Authors: Nilesh Jaiswal . , Parulben Mehta .
Published: October 2024

Malaria affects millions of people every year, especially in our world. The main treatments are oral antibiotics and vaccines. The rise of the malaria parasite, now resistant to most anti-viral drugs, is causing a global crisis. Furthermore, low water solubility and permeability of both new and old antibiotics cause limited oral bioavailability and non-compliance from patients. Lipid formulations are frequently employed to lessen toxicity, boost solubility, and improve effectiveness. The findings of studies on oral-specific lipophilic drug delivery systems, such as self-emulsifying drug delivery systems, are reviewed in this article. (SEDDS). SEDDS increases the absorption of anti-inflammatory drugs by promoting the formation of liquid emulsions that dissolve the drug in the intestine. However, traditionally used SEDDS are usually in liquid form, administered into the oral cavity, and have poor safety. This article discusses a new solidification process that can be easily and economically scaled up by using existing equipment. This strategy might also increase patient compliance and product stability. Oral SEDDS has a substantial potential influence in the fight against malaria.
Chrysin Embedded Metal Organic Framework for Anticancer Drug Delivery.
Authors: Patil VK . , Patel JK . , Patel AK .
Published: October 2024

Metal-organic frameworks (MOFs) have garnered significant attention in the field of cancer drug delivery owing to their porosity, high drug-loading capacity, and large surface area. In our recent research, we synthesized a redox-responsive MOF using zirconium (Zr) as the metal ion and 4,4-dithiobisbenzoic acid (DTBA) as the organic linker. The synthesis method employed was the hydrothermal method, and it was observed that the MOF synthesized at 400°C had a particle size of less than 200 nm and a zeta potential of +35 mV, indicating its suitability as a carrier for drug delivery. Chrysin, a natural anticancer drug, was used in this study. Glutathione, which is abundantly present in tumor cells, cleaves the disulfide bond in the organic ligand (DTBA), leading to faster drug release. By incorporating chrysin into the synthesized MOF, we observed faster in vitro drug release, with 88 and 89% at pH 7.4 and 5.5, respectively. The synthesis of ZrDTBA MOF opens up new opportunities for its application in drug delivery.
Impact of Nanoethosomes Loaded with Polyherbal Extracts on the Mechanisms Involved in Wound Healing In-vitro Research.
Authors: K Mekala . , SM Shaheedha . , R Prakash .
Published: October 2024

This study focuses on formulating and optimizing Polyherbal Nanoethosomes for controlled drug delivery, utilizing a polyherbal extract comprising Basella alba L., Portulaca oleracea L., Lawsonia inermis L., Trigonella foenum L., and Peristrophe paniculata L. Comprehensive characterization revealed a variety of secondary metabolites within the extract. The primary goal was to create poly herbal extract-entrapped ethosomes that could be integrated into a sustained-release transdermal gel dosage. We prepared nanoethosomes using phosphatidylcholine, ethanol, Tween 80, and SLS, and optimized them using Design Expert software. The characteristics included size (particle size: 121 ± 2.60 nm) and entrapment efficiency (81.91 ± 1.92%), followed by incorporation into a carbopol gel for skin application. We performed in-vitro permeation studies and cytotoxic assays on L-929 cells, which revealed favorable outcomes. Optimized nanoethosomes displayed desirable particle characteristics, highlighting their potential for controlled drug delivery. The nano vesicular gels had good rheological and physical properties (polydispersity index: 0.41 ± 0.04, zeta potential: -8.12 ± 1.25 mV), which meant they could be used topically. This research underscores the compatibility of plant extracts with formulation components, offering a foundation for Polyherbal Nanoethosomes in pharmaceutical formulations. The study emphasizes precise control over particle attributes and suggests potential applications in enhancing drug release and bioavailability.
Preparation of Mouth Dissolving Sublingual Film of Fixed Dose Combination of Hydrochlorothiazide and Losartan Potassium and Statistical Optimization of Film.
Authors: V Attal . , K Daniel .
Published: October 2024

Fast-dissolving films (FDFs) are innovative dosage forms offering advantages such as improved patient compliance, rapid onset of action, precise dosing, and favorable taste. Particularly beneficial for patients unable to swallow or require immediate drug absorption, FDFs dissolve rapidly in the mouth, releasing medication directly into the oral cavity. The sublingual application enhances drug delivery due to the high permeability of the sublingual mucosa, bypassing hepatic first-pass metabolism. This route is advantageous for drugs like losartan potassium (LP) and hydrochlorothiazide (HCZ), which benefit from enhanced bioavailability and faster onset of action. Preformulation studies included UV spectroscopy for λmax determination (LP: 282 nm, HCZ: 250 nm), DSC for thermal analysis (LP: 289.11°C, HCZ: 104.76°C), and solubility studies confirming LP’s solubility in acidic pH and HCZ’s increased solubility in pH 6.7 buffer. Compatibility studies using FTIR and DSC validated stability with excipients. Formulation optimization with HPMC E15 resulted in films with characteristics like film weight (145.66–167.0 mg), thickness (0.246–0.326 mm), folding endurance (898.0–1274.0), pH (6.0–6.70), disintegration time (77.66–174.6 s), tensile strength (77.04–141.90 g/cm²), and drug release profiles (LP: 68.78–96.22%, HCZ: 59.49–95.43% at 21 minutes). In summary, this study successfully developed LP and HCZ FDFs with optimized characteristics, demonstrating their potential in hypertension management and improving therapeutic outcomes.
Spectrophotometric Assessment of Pyrocatechol Drug Employing Oxidative Coupling Reaction with 4-amino antipyrine as a Model of Pharmaceutical Compounds .
Authors: Ali Abbas Fadhil , Rahi Mustafa Aziz , Altameemi Kamil K Atiyah , Al-hussainawy Mohammed Kassim , Abdulhussain Munthir Abdulwahid
Published: October 2024

A rapid, simple, sensitive, and higher stability spectrophotometric method was developed the determine that it is stable Pyrocatechol drug in pure and pharmaceutical preparations. The method is based on an oxidative coupling reaction among Pyrocatechol drug and 4-amino antipyrine (4AAP) in the presence of potassium iodate (KIO3) in an acid medium to form a color complex that stable violet dye and a maximum absorption at 505 nm. The best optimum conditions and other analytical factors have been evaluated. A calibration curve of absorbance of several concentrations that obey the law of Beer-Lambert over the range concentration of pyrocatechol drug 10 to 100 mg/L, with (LoD =1.2*10-4 mg/L), (LoQ=3.4*10-4 mg/L), The relative standard deviations RSD% of the proposed methods were less than 0.68%). In contrast, recovery average and determination parameters are 99.9%. The method was used successfully for the determination of drugs in a pharmaceutical preparation with the best accuracy and precision. At range about 99.1 to 100.2% with RSD less than 0.3%. The analytical result for the estimation of the pure drug is presented together with the use of the proposed process for the analysis of some commercial pharmaceuticals. The data compare favorably with those of official and reported ways.
Development and Optimization of Gellan Gum-Based Gastro-Retentive Microbeads for Enhanced Controlled Release of Acyclovir.
Authors: Sethi Ranjan Kumar , Sahoo Sunit Kumar , Guru Pravat Ranjan
Published: October 2024

Modified release systems offer enhanced spatial and temporal control over drug delivery, leading to better blood plasma profiles, targeted therapy, reduced side effects, and improved patient compliance. Recent advancements focus on using biocompatible polymers to achieve sustained or controlled drug release, particularly for gastroretentive systems that enhance oral bioavailability and minimize dose-dependent toxicity. This study explores the formulation of floating microbeads of acyclovir (ACV) using various hydrophilic polymers. The prototype oral formulations demonstrated superior micrometric properties, including bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose, average particle size, yield, and drug content. In-vitro dissolution studies revealed controlled release characteristics, with optimal floating time and entrapment efficiency achieved using specific concentrations of olive oil and polymers. Drug release trailed the Korsmeyer-Peppas model, indicating a diffusioncontrolled mechanism. The formulations exhibited good storage stability, in-vivo floating ability, and higher bioavailability in rabbits compared to ACV solutions. The results suggest that hydrophilic polymers are effective for formulating floating microbeads with controlled release and reproducible profiles.
Design and Optimization of Ibuprofen and Ranitidine Hydrochloride TriLayer Tablets in Immediate Release Formulation by Quality by Design.
Authors: V Karthikeyan . , Soni Rupesh .
Published: October 2024

The current trend in pharmaceutical process development and optimization is known as quality by design (QbD). This methodical approach is founded on the concept that quality should be integrated into the product from the start, rather than assessed after manufacture. In this study, we demonstrate methods to improve the process parameters for making tri-layer tablets by applying QbD principles in a methodical way. Dependent elements with high to medium impact on the process. According to the study’s results, all systems showed signs of instant release. It appears that the structure of each formulation and the properties of the polymer utilized have a significant impact on the rate and mechanism of drug release. Substantial medication release is observed in the three-layer formulations. Both the pace and mechanism of drug release are significantly affected by the tablet’s geometrical features and structure, as well as the weight and thickness of the barrier layers. While data suggested that Fickian diffusion was primarily responsible for drug release in two-layer tablets, three-layer tablets showed signs of either anomalous diffusion or erosion/relaxation. Therefore, the drug was stabilized as immediate-release directly compressible triple layered Average core weight of tri-layered tablets (mg) was 1000 for ibuprofen, 100 for placebo and 200 for ranitidine, thickness (mm) was 9.00 ± 0.3, hardness (N) was 110 ± 25, core tablet weight was 1300.000 ± 2% mg and coated tablet weight was 1325 mg. Using other moisture-sensitive medications. This study provides the foundation for future research into optimizing the properties of tablets made by direct compression.
Formulation and Evaluation of Sustained Release Dosage Form of Venlafaxine Hydrochloride for Enhanced Treatment of Neurodisorders
Authors: Mhaske Nilesh Sureshrao , Kumar S Sathesh
Published: October 2024

In the present study, we have designed and developed a sustained-release tablet formulation of Venlafaxine Hydrochloride. The optimized formulation was then subjected to various evaluation parameters. The formulation of venlafaxine hydrochloride sustained release tablets with a dosage of 500 mg included the utilization of several hydrophilic polymers, including jackfruit mucilage, HPMC K4, and PVPK30, as release retardants. This was done to extend the duration of drug release to 12 hours. The formulation features, including pre-compression and post-compression investigations, were conducted individually according to established protocols. The tablets were determined to be compliant in terms of weight uniformity, hardness, thickness, diameter, friability, and drug content. Separate in-vitro dissolution studies were done for both tablets. The venlafaxine hydrochloride SR formulation F18 was optimized to provide the desired release profile for up to 12 hours. The Venlafaxine Hydrochloride SR formulation was optimized and exhibited zero-order release kinetics. The stability studies conducted under accelerated conditions at a temperature of 40 ± 2°C and a relative humidity of 75 ± 5% yielded good results. The study indicated that the sustained release administration of Venlafaxine HCl is potentially efficacious. It reduces the frequency at which the patient has to take medication and improves patient adherence. Our objective is to conduct in-vivo pharmacokinetic studies of the formulation to verify the drug’s entry into the systemic circulation.
Antihypertensive Activity of Peptides Derived from Toman Fish Albumin (Channa micropeltes): In-silico Angiotensin-Converting Enzyme Inhibitory Study.
Authors: Komari Noer . , Hadi Eko . , Bhusari Samsul . , Mustikasari Kamilia . , Putera Gusti Muhammad Perdana
Published: October 2024

The peptides from protein hydrolysis can be as bioactive peptides. Currently, the process of protein hydrolysis can be done in-silico technique, an alternative to bioactive peptide identification more effectively and efficiently. This study aims to predict bioactive peptides in-silico technique of albumin hydrolysis from Toman Fish (Channa micropeltes), which had the potential as an antihypertensive drug. Toman fish albumin sequence (A0A191TFW5) was obtained from the UniProt database. The identification of bioactive peptides was performed by simulating enzymatic hydrolysis with three human digestive enzymes: trypsin, chymotrypsin, and pepsin. The hydrolysis simulation of albumin was conducted using the ExPASy PeptideCutter program. The generated peptides’ potential activities, solubility, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties were predicted using various online prediction tools. Molecular docking was performed on the bioactive peptides to determine the Gibbs free energy (∆G) and to illustrate the interaction between the bioactive peptides and the active site of the Angiotensin Converting Enzyme (ACE) as a comparison was used captopril which was a commercial ACE inhibitor. The results showed that bioactive peptide candidates were AI, VL and LVP. These peptides were potentially a candidate for alternative antihypertensive drugs.
Formulation Development of Mucoadhesive Vaginal Gel of Secnidazole and Voriconazole.
Authors: VR Vaidya . , PV Powar , SV Pandya , VD Yadav VD .
Published: October 2024

Purpose: Over the preceding decades, developing conventional drug delivery in to modified form has acquired importance in the pharmaceutical industry. Vaginal drug delivery system offers localized drug administration of drug and also avoids unwanted side effects of oral drug delivery. Vaginal drug delivery system has significant role in medical practice. Even though VDDS has a lot of advantages over the other routes of administration. The goal of developing the Mucoadhesive Vaginal Gel was to achieve the synergistic effect of voriconazole and secnidazole in the treatment of bacterial and fungal vaginal infections. Method: Mucoadhesive antimicrobial vaginal gel was optimised using Design expert software using Carbopol 934, HPMC K4M polymers. Result: Formulation was evaluated for various rheological parameters ,antimicrobial activity, invitro drug release and stability study. The spreadability and pH was found to be 5.5 to 7.4 cm and 4.12. Its compatible with vaginal pH. The selected optimized F8 formulation is the best formulation and the drug ratio is 2:1. and optimum gel viscosity is 1874 cps. antimicrobial study revealed that faster drug release of test formulation was compared to marketed product. It indicates as inhibition zone. Conclusion: The combination of drugs can serves as better option for treating vaginitis, compared to single drug formulation. Mucoadesion increases contact time of drug with affected area which rendered formulation more effective.
The Milling Method in Formation of Inclusion Complex p-Methoxycinnamic Acid-Hydroxypropyl-β-Cyclodextrin.
Authors: Isadiartuti Dewi . , Yusuf Helmy . , Setyawan Dwi . , Ekowati Juni .
Published: October 2024

p-methoxycinnamic acid (pMCA) is a substance with several pharmacological activities, derived from the rhizome of Kaempferia galanga Linn. The solubility of pMCA can be increased by the formation of inclusion complexes (IC) using hydroxypropyl-βcyclodextrin (HPβCD) compounds. IC are obtained through the milling method, which is a simple, environmentally friendly, and low-cost manufacturing method. The process involves the pounding of material with a certain speed and impact force. This research aims to characterize the pMCA-HPβCD IC made using the milling method. Milling the mixture of pMCA and HPβCD using a ball mill is a common technique to enhance the formation of the inclusion complex. The IC’s physical characteristics were analyzed in terms of their morphology, particle size, crystallinity, and thermal properties. The dissolution profile was also performed using paddle-typed dissolution apparatus (Type II) with 500 mL distilled water as dissolution medium. The amount of pMCA dissolved was determined using UV spectrophotometry. The dissolution parameter was determined as dissolution efficiency at 60 minutes (DE60). The IC particles were irregular in shapes and porous. The size was reduced as compared to the individual components. The XRD revealed that the ICs were amorphous. The DE60 of IC increased by a factor of 4.3 compared to the pure pMCA. In conclusion, the milling method successfully formed complex of pMCA-HPβCD with different characteristics from the initial compound and was significantly increased the percentage of the dissolved pMCA.
Graphene-Based Nano Drug Delivery of Curcumin for the Treatment of Dengue Fever.
Authors: Pritam Das , Amita Rana , Mahendra Rana
Published: October 2024

Graphene, which is defined as a single-layered sp2 hybridized carbon atoms placed in a honeycomb-like crystal lattice when converted to graphene oxide, has proven its worth by showing its tremendous capacity in controlling the release rate of drugs by entrapping in the numerous pockets present inside it through π-π stacking interaction when used as a nanocarrier. In this experiment graphene oxide was synthesized through traditional Hummer’s method and was used as a nanocarrier to target nanosized drugs, which was prepared by loading curcumin drug into the PVP functionalized graphene oxide by using necessary procedures. After the successful confirmation of the stability, functionalization, and compatibility through various characterization procedures and effective drug loading into the systems, the release behavior of the formulations has been checked through dialysis bag diffusion technique using potassium phosphate buffer saline (pH 7.2, 4.0 and 9.2) for selection of the best medium for determination of the successful sustained-release behavior of the drugs through the dialysis membrane which concluded with satisfactory, sustained and constant drug release phenomenon in the acidic environment reflecting an idea of the fact its favorable release in acidic pH. It is a fact known that dengue fever causes systemic acidosis i.e., reduction of the pH of blood below 7. Thus, when used in-vivo there is a possibility that the formulation has easy access to its target and, performs the desired mechanism of action and can be used as a therapeutic delivery system against the Dengue virus.