bluuebunny/crossref_metadata_2025 huggingface dataset:
Cerebrospinal Fluid Total Tau Is Associated with Shorter Survival in Dementia with Lewy Bodies
Authors: Boström Fredrik , Hansson Oskar , Blennow Kaj , Gerhardsson Lars , Lundh Thomas , Minthon Lennart , Zetterberg Henrik , Londos Elisabet
Published: October 2009

A pathology typical of dementia with Lewy bodies (DLB) has been demonstrated to increase mortality to a greater extent than the pathology of Alzheimer’s disease (AD). However, mortality in DLB has also been shown to increase with concomitant AD pathology. Furthermore, in a recent publication, we showed that there is a robust and specific increase in CSF calcium and magnesium in DLB patients compared to both AD patients and controls. Thus, in order to explore the influence of CSF AD markers and trace element concentrations on mortality in DLB, we undertook a longitudinal prospective study of 47 clinically diagnosed DLB patients and 157 AD patients as well as 49 healthy volunteers. Both AD and DLB patients showed an increased mortality compared to the healthy controls (relative risk: 10 and 8, respectively; p < 0.001). Increased levels of CSF total tau were associated with increased mortality among the DLB patients (p < 0.05), but not among the AD patients or controls. Gender, age, MMSE score, Aβ42 concentration and phosphorylated tau, and CSF trace element concentrations did not influence survival in the obtained models.
High Systolic and Pulse Pressure Levels Are Associated with Better Cognitive Performance in Patients with Probable Alzheimer’s Disease: A Cross-Sectional Observational Study in a Geriatric Outpatient Population
Authors: van Bruchem-Visser Rozemarijn L. , Mattace-Raso Francesco U.S. , van der Cammen Tischa J.M.
Published: October 2009

Background: The prevalence of cardiovascular disease and Alzheimer’s disease (AD) increases with age. A number of studies have demonstrated an association between AD and cardiovascular risk factors and disease. However, data are inconsistent. Methods: Cross-sectional observational study in a geriatric outpatient population. Analysis of data from 327 patients diagnosed with probable AD in a geriatric outpatient clinic. Comparison of blood pressure levels, cardiovascular diagnoses, and Mini-Mental State Examination (MMSE) score between the patients. Results: MMSE score decreased with age (β = –0.25; 95% CI: –0.35 to 0.15), and a positive correlation was found with systolic blood pressure (β = 0.03; 95% CI: 0.003–0.06), pulse pressure (β = 0.05; 95% CI: 0.01–0.08) and hypertension (β = 1.56; 95% CI: 0.05–3.07). An increase in cardiovascular disease load had a negative effect on cognitive performance. After adjustment for duration of dementia (data present for 216 patients), results were slightly changed. Conclusions: Higher systolic blood pressure and pulse pressure were associated with a better cognitive test performance. Patients with probable AD and 2 or more cardiovascular diagnoses had lower MMSE scores.
Expert Systems in Dermatology: The Computer Potential
Authors: Finlay A.Y. , Hammond P.
Published: October 2009

The expert system approach to computer diagnosis uses a non-algorithmic method to represent and manipulate an expert’s knowledge and reasoning. This information, which may be provided by a dermatologist, is represented by rules in a logic-based computer language in order to provide interactive and explanatory features. The major advantages of using expert system techniques for computer-aided diagnosis in dermatology are that (1) knowledge is made explicit, (2) the heuristic nature of an expert’s knowledge can be more easily captured and (3) the more easily readable programs make modification easier. In the example described, the differential diagnosis of nine facial skin tumours was considered. The program, using the language ‘micro-PROLOG’ in an expert system shell ‘APES’, consists of ‘rules’ and ‘facts’ which define a relationship between patient and symptom, symptom and disease or disease and therapy. The ‘strength’ of each relationship is defined and ‘key symptoms’ identified. The system finally offers a diagnosis, an estimate of certainty and simple management advice.
Mercury Intoxication after Topical Application of a Metallic Mercury Ointment
Authors: Bourgeois M. , Dooms-Goossens A. , Knockaert D. , Sprengers D. , Van Boven M. , Van Tittelboom T.
Published: October 2009

Two cases of mercury poisoning with predominantly dermatological symptoms are reported. The mercury intoxication was caused by the application of an over-the-counter metallic mercury ointment. The calculations of mercury excretion suggest strongly that cutaneous absorption could have been a significant route of entry.
Multiple Agminate Juvenile Melanoma
Authors: Orita M. , Obara K. , Irimajiri T. , Kobayashi M.
Published: October 2009

A multiple agminate juvenile melanoma of the right ear lobe occurred in a 46-year-old man.
Lipoprotein Metabolism and Lipoprotein Lipase in Severe Cystic Acne
Authors: Pigatto Paolo , Altomare Gian Franco , Negri Marco , Finzi Aldo Fabrizio , Vigotti Glauco , Vergani Carlo
Published: October 2009

In severe cystic acne we found low levels of high density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A) in the presence of normal total lipids. In a larger number of patients, we always observed significantly lower levels of HDL-C and Apo-A than in either age-matched controls or subjects with acne vulgaris. Since lipoprotein lipase is one major determinant of HDL concentration, we assayed the lipase activity in liver and extrahepatic tissues by the method of Krauss et al. There was highly significant less total and hepatic lipase activity than in age-matched controls. HDL distribution was examined by zonal ultracentrifugation and a decrease in the HDL2 subclass was discovered. Since HDL are inversely correlated to atherosclerosis, cystic acne is one risk factor for atherosclerosis. The linkage between low HDL levels and severe cystic acne should be further investigated.
Leser-Trélat Sign in Mycosis fungoides
Authors: Toonstra J. , Ramselaar C.G. , van der Putte S.C.J.
Published: October 2009

A 61-year-old woman is presented who developed numerous seborrheic keratoses within a few weeks. About 2 months later the patient noticed a progressive generalized erythematosquamous eruption on which the diagnosis of mycosis fungoides was made. PUVA therapy resulted in complete remission of the mycosis fungoides lesions together with a resolution of the seborrheic keratoses. This is the third report of the Leser-Trélat sign in mycosis fungoides. The cases associated with malignant lymphomas are briefly reviewed.
Gonoblennorrhoea adultorum (Gonococcal Conjunctivitis) – A ‘Disappearing Disease’ Which Does Not Disappear
Authors: Korting H.C. , Neubert U. , Abeck D. , Jordan R. , Luderschmidt C.
Published: October 2009

Gonoblennorrhoea adultorum (GA) still occurs in spite of contrary statements. During the last 10 years, 4 cases were seen in the Munich Clinic of Dermatology (constituting 0.19% of all patients with gonorrhoea). While the conjunctivae alone were involved in 3 of them, in 1 the cornea showed alterations as well. Thus, the disease has not lost its potential danger. Yet the newer cephalosporins seem to cure GA rapidly, even if given in a single dose (together with local treatment).
Immunological Alterations in a Case of Papillon-Lefèvre Syndrome with Recurrent Cutaneous Infections
Authors: Borroni G. , Pagani A. , Carcaterra A. , Pericoli R. , Gabba P. , Marconi M.
Published: October 2009

An immunological study was performed in a 16-year-old boy affected with Papillon-Lefèvre syndrome (PLS) and recurrent staphylococcal cutaneous infections. A defect of neutrophil intracellular killing of Staphylococcus aureus and a decreased lymphocyte proliferative response to phytohaemagglutinin were detected. The possible role of these alterations in promoting recurrent infections in PLS is discussed.
Jadassohn’s Intraepidermal Epithelioma
Authors: Prado Cruces , de la Torre C.
Published: October 2009

We present a case which may be labeled Jadassohn’s intraepidermal epithelioma, but which has led us to revise the problem of intraepidermal neoplasias, and establish whether or not this entity possesses distinct features which would permit us to differentiate it.
Mononucléose infectieuse avec manifestations cutanées à type d’acrosyndrome de Gianotti-Crosti
Authors: Ramelet A.-A.
Published: October 2009

A 6-year-old boy is reported with infectious mononucleosis and a monomorphous papular eruption on the face, buttocks and limbs, as described by Gianotti and Crosti. Three types of juvenile papular acrodermatitis are to be distinguished: Gianotti-Crosti’s disease, the papular acrosyndrome of Gianotti-Crosti and the papular acral manifestations caused by various viral infections. But might these eruptions not rather be the cutaneous symptom of a viral affection?
Unilateral Skin Lesions Associated with Multiple Neoplasms
Authors: Burck Uta , Arnold Hans , Siebert Joachim
Published: October 2009

A girl with unilateral partly depigmented, partly hyperpigmented atrophic skin lesions, hypertrichosis, postauricular nodules, cataracts, and mild mental retardation is presented. Additionally, she developed multiple neoplasms as optic glaucoma, a psammomatous meningioma and an ameloblastoma. It remains unclear whether our patient suffers from a variant of the epidermal nevus syndrome or a new neuro-ectodermal dysplasia.
A Critical Evaluation of a Method for Treatment of Facial Hypertrichosis in Women
Authors: Verdich Jesper
Published: October 2009

An electroepilation apparatus equipped with a metal tweezer was studied with reference to possible permanent removal of facial hair in women with cosmetically embarrassing hypertrichosis. 8 women were epilated on a fixed area of 1 cm2 and counts of the epilated hairs were done. 5–7 months later, the same area was epilated and the terminal hairs counted. No significant difference in the hair counts was found on the two epilations. The method must be considered inapplicable for permanent removal of superfluous hair.
Epithélioma calcifié de Malherbe à type histologique particulier
Authors: Kanitakis J. , Hermier C. , Chouvet B. , Thivolet J.
Published: October 2009

A case of calcifying epithelioma (of Malherbe) is reported, which seems to be developing on an epidermal cyst: microscopic examination shows a sudden transformation of the wall of the epidermal cyst into a calcifying epithelioma. This histological feature is very rare: only 2 similar cases have been reported in the literature until now.
Recurrent Pyogenic Granuloma with Multiple Satellites
Authors: Amérigo J. , González-Cámpora R. , Galera H. , Sánchez-Conejo J. , Moreno J. , Sotillo I.
Published: October 2009

The condition wherein multiple satellite angiomatous lesions develop around the scar of a recently treated pyogenic granuloma is a rare occurrence. To date 30 such cases have been reported. One additional case is described and ultrastructural examination is carried out. The pathogenesis of this entity is considered in relationship to an angiogenic factor elaborated by the primary lesion.
Homocystinurie. Étude histologique et ultrastructurale
Authors: Meynadier J. , Guilhou J.J. , Thorel M. , Barneon G.
Published: October 2009

The histological and ultrastructural appearance of the skin is reported in a case of homocystinuria. By optical microscopy, the collagen fibers appear granulose and non fascicular in the superficial dermis; in the deeper layers they are rare; the elastic network of the medium and lower dermis is thick and disrupted. Electron microscopically, some fibroblasts exhibit large autophagic vacuoles; the collagen fibers are normal while the elastic fibers are broken and dense; the dermal capillaries are normal. Vitamin B6 has shown its action by recoloring the patient’s hair.
Systemic Lupus erythematosus and Vasculitic Urticaria
Authors: Ruzicka Thomas , Goerz Günter
Published: October 2009

Dapsone 100 mg daily led to a rapid and complete clearing of extensive vasculitic urticarial lesions in a female patient with systemic lupus erythematosus. Complement determinations revealed an intensive activation of the classical pathway before dapsone therapy. Normalization of CH50, C1 and C2 occurred during the treatment, whereas C3 and C4 remained lowered.
Les onychomycoses à moisissures
Authors: Achten G. , Wanet-Rouard J. , Wiame L. , Van Hoof F.
Published: October 2009

The authors studied in vitro and in vivo the invasion of the nail keratin by saprophytes. This invasion takes place in the same way in both cases: mycelian filaments and spores penetrate in the hyponychium, filaments penetrate in the upper part of the tablet, filaments and, as far as some saprophytes are concerned, ‘boring hyphae’ penetrate in the lower part of the tablet. Those ways of invasion are responsible for the clinical pictures (onychomycosis, pachyonychia, leuconychomycosis). Electron microscopically the mycelian filaments appear to be both intercellular and intracellular. The authors insist on the importance of the criteria of evaluation which allow us to establish the saprophytic origin of onychomycosis.
L’aspergillose expérimentale de la souris
Authors: Haller I.
Published: October 2009

The experimentally induced aspergillosis of mice is discussed as a useful parameter for the screening of new antimycotics. There are important differences between this test model and aspergillus infections in humans. Mice must be infected intravenously with more than 106 spores of Aspergillus fumigatus to provoke multiple abscess formation in the kidneys which induces an acute, lethal course of infection. Intratracheal administration of 2 × 106 spores did not evoke any symptoms. The therapeutic efficacy of several antimycotics was examined; amphotericin B, 5-fluorocytosine and BAY h 4364 – as the only imidazole-derivative – proved to be effective.
Treatment of Basal Cell Carcinoma of the Skin with 5-Fluorouracil Ointment
Authors: Reymann Flemming
Published: October 2009

During the period 1966–1968, 88 patients with a total of 95 basal cell carcinomas were treated with 5% 5-fluorouracil ointment. A follow-up study carried out from November 1977 to January 1978 revealed a total of 12 recurrences in 56 surviving patients with 56 basal cell carcinomas. The recurrence rate is thus 21.4%. It is concluded that there is hardly any indication for using 5-fluorouracil in local treatment of nodular basal cell carcinoma.
Cutaneous Manifestations Associated with Aminoaciduria
Authors: Haim S. , Gilhar A. , Cohen A.
Published: October 2009

This is a report of 2 cases revealing photosensitivity in association with aminoaciduria. The first is a patient with psoriasis and the second, a patient with Ehlers-Danlos syndrome, mitis type. The display of the above combinations seems peculiar. The psoriatic lesions become confined mainly to the exposed surface and intermingled with those of photodermatitis forming lesions which are a mixture of the two processes. In the case with Ehlers-Danlos, the disease presented rupioid plaque-like erythematous oozing lesions which seem somewhat different from those of the photodermatosis yet known.
Woringer-Kolopp Disease
Authors: Toribio Jaime , Quiñones Pedro A.
Published: October 2009

A typical clinical and histologic case of so-called ‘pagetoid reticulosis’ or Woringer-Kolopp disease is reported. This is a chronic cutaneous condition usually with a single focus or at most with a few patches confined to a circumscribed region. A disseminated form has been described as Dupont-Vandaele type, but its relationship to the classic Woringer-Kolopp disease is uncertain. The nosological location of pagetoid reticulosis has not been established, but there are reasons to regard it as a particular and well-defined entity. In relation to the nature of this condition and to the origin of the ‘pagetoid cells’, it is tempting to consider the possibility that Woringer-Kolopp disease might be a lymphoproliferative epidermotropic disorder, classifiable as a benign form of ‘cutaneous T-cell lymphoma’, but the early histologic changes are rather indicative of an epidermal origin.
Angiokeratoma of Vulva
Authors: Verbov Julian , Manglabruks K.
Published: October 2009

A female of 66 who presented with long-standing pruritus vulvae showed angiokeratoma of the vulva as an incidental finding. This benign tumour is uncommon and in a survey of 150 patients over 50 years old (mean age 76.9), no further example was found.
Dapsone-Induced Distal Axonal Degeneration of the Motor Neurons
Authors: Helander I. , Partanen J.
Published: October 2009

Dapsone proved to be an effective treatment in a patient who suffered from erythema elevatum diutinum. Serious neurological side effects, however, appeared. The basic mechanism appeared to be a distal axonal degeneration of the motor neurons. Sensory conduction studies were normal in five consecutive EMG examinations. A diagnosis of anemia perniciosa was also made but the blood values returned to normal after starting B12-vitamin therapy. Pernicious anemia seemed not to be an etiological factor in the polyneuropathy of our patient because we were not able to show any damage to the sensory axons.
Prevalence and Cardiovascular Features of Japanese Hemodialysis Patients with Fabry Disease
Authors: Fujii Hideki , Kono Keiji , Goto Shunsuke , Onishi Tetsuari , Kawai Hiroya , Hirata Ken-ichi , Hattori Kiyoko , Nakamura Kimitoshi , Endo Fumio , Fukagawa Masafumi
Published: October 2009

Background: Fabry disease (FD) is a rare disease and one of the causes of progressive renal dysfunction. It results from an X-linked deficiency of α-galactosidase A activity. It has been reported that its prevalence is much higher in hemodialysis patients than in the general population. However, its prevalence in Japanese hemodialysis patients and cardiovascular manifestations remain unclear. Methods: We screened the α-galactosidase A activity of 1,024 Japanese hemodialysis patients using a dried blood spot test. Patients with a low α-galactosidase A activity were assessed clinically, and a genetic study of the α-galactosidase A gene was performed for these patients. Furthermore, patients with FD underwent detailed cardiovascular examination. Results: Forty-six patients had low α-galactosidase A activity, and 1 man and 2 women had α-galactosidase A mutations (0.29%). All of these patients had a previously identified mutation (E66Q). The result of detailed cardiovascular examination showed that 2 patients had significantly impaired coronary flow reserve, reduced myocardial contraction and relaxation tissue Doppler velocities, and left ventricular hypertrophy. Conclusions: Measurement of the α-galactosidase A activity and the results of a genetic analysis indicated that the prevalence of FD in our hemodialysis patients was 0.29% (0.16% in men and 0.5% in women). Furthermore, comprehensive examination detected cardiovascular abnormalities in Japanese hemodialysis patients with FD.
Pseudolymphoma Syndrome
Authors: Halevy Sima , Feuerman Eleasar J.
Published: October 2009

A transient dermatologic abnormality which gave a histologic picture compatible with malignant lymphoma is described. The clinical manifestations included diarrhea, hepatosplenomegaly, moderate lymph node enlargement without histopathological changes and evidence of involvement of the reticulo-endothelial system. Both the dermatologic and gastrointestinal disorders appeared approximately 1 year after discontinuation of treatment with diphenylhydantoin, which the patient had taken for 2 years. The possible association between the transient abnormality and the previous diphenylhydantoin therapy justifies the classification of this case as ‘pseudolymphoma syndrome’.
Hautvasokonstriktionseffekt von Kontaktantiphlogistika
Authors: Weirich Erich G. , Lutz Ulrike C.
Published: October 2009

Five contact antiphlogistics were evaluated and compared to hydrocortisone by the human skin vasoconstriction assay in 20 volunteers. The test concentrations ranged from 10––2 to 10––6 w/w; the duration of occlusive application was 16 h. The substances could be ranked as follows in ascending order of activity.
Anhidrotic (or Hypohidrotic) Ectodermal Dysplasia
Authors: Martin-Pascual A. , de Unamuno P. , Aparicio M. , Herreros V.
Published: October 2009

A case with anhidrotic ectodermal dysplasia is reported. He is a male belonging to a family which could suggest a recessive X-linked pattern of inheritance. The characteristics which are found in this patient are compared with those described by other authors in the medical bibliography.
Topical Parabens: Benefits and Risks
Authors: Lorenzetti O.J. , Wernet T.C.
Published: October 2009

Parabens are the most frequently used preservative in dermatological medications. Some allergies have been reported to parabens, but these risks must be considered with respect to the benefits of parabens in concentrations used as preservatives in dermatological formulations. Considering the alternatives to parabens in preservatives and placing perspective on the reported allergies we still find parabens to be a useful preservative with minimal risk relative to its benefits.
Hodgkin’s Disease and Mycosis Fungoides in a Married Couple
Authors: Hazen Paul G. , Michel Beno
Published: October 2009

Hodgkin’s disease and mycosis fungoides are malignancies in which there is abnormal T lymphocyte proliferation. The authors report the occurrence of Hodgkin’s disease and mycosis fungoides in a husband and wife, respectively. This represents another instance of clustering of cases of T lymphocyte malignancies.
Role of Keratinases in Dermatophytosis
Authors: Grappel Sarah
Published: October 2009

Complement-fixing antibodies to the heat-inactivated keratinase II of Trichophyton mentagrophytes var. granulosum were detectable in sera from approximately 40% of the Hartley strain guinea pigs previously infected with this dermatophyte. However, no precipitating antibodies to the heat-inactivated keratinase II were detectable in these sera. Guinea pigs immunized with the heat-inactivated keratinase II had both complement-fixing and precipitating antibodies to the keratinase II. Circulating antibodies in sera from both the infected and the immunized guinea pigs also reacted with the active keratinase II but did not inhibit its proteolytic activity.
A Comparative Study of Skin Tests and Determination of the Serum Level of Specific IgE Immunoglobulins by Means of the Radioallergosorbent Test in Subjects with Atopy
Authors: Waterman A.H. , van der Ent G.M.
Published: October 2009

On 73 patients suspected for atopic diseases, 258 skin tests and radioallergosorbent tests (RAST) for specific IgE in serum were carried out. The results of both tests were compared in connection with the clinical picture. A good qualitative positive correlation was found, especially for grass pollen and house dust. False positive results with RAST cannot be excluded. The RAST seems to be a valuable adjunct to extensive allergologic diagnostic investigation, particularly in cases where difficulties can be expected in the performance or the interpretation of skin tests.
Retinal Vascular Abnormalities in Patients with Cerebral Amyloid Angiopathy
Authors: Lee Andrew , Rudkin Adam , Agzarian Marc , Patel Sandy , Lake Stewart , Chen Celia
Published: October 2009

Objective: To describe the ophthalmology findings in patients with cerebral amyloid angiopathy (CAA). Methods: Data source and subjects: 7 consecutive patients admitted to a tertiary stroke unit with CAA-related hemorrhage, confirmed on magnetic resonance brain imaging gradient echo sequences by 2 independent neuroradiologists. Design: case series. Measurements and data analysis: fundus colored photographs and fundus fluorescein angiography. Results: All patients showed bilateral multiple dot and blot hemorrhages as well as multiple microaneurysms on fundus fluorescein angiography. Conclusion: Microaneurysms and dot and blot hemorrhages funduscopically mirror the histopathology of CAA. This case series is the first to describe retinal vessel changes in CAA and, if confirmed in larger population studies, has the potential to provide insights into the natural history of CAA.
The Mechanism of Photochemotherapy
Authors: Gmeiner B. , Raab W.
Published: October 2009

As a contribution to the mechanisms of photochemotherapy, human skin homogenates were irradiated in the presence or absence of methoxsalen. The changes induced in LDH-, G-6-PDH-, GAPDH-, and GOT-activities were registered. Methoxsalen (50 μg/ml) failed to produce any significant effect. On pure G-6-PDH, methoxsalen exhibited a photoprotective action.
Antimicrobial Effectiveness of Locacorten-Vioform® Cream in Secondary Infections of Common Dermatoses
Authors: Konopka E.A. , Kimble E.F. , Zoganas H.C. , Heymann H.
Published: October 2009

In a double-blind study involving 430 patients, Locacorten (0.02%)-Vioform® (3%) cream was found to be highly effective in the treatment of dermatological conditions complicated by secondary bacterial involvement. The microbiological conversion and clinical improvement in patients treated with Locacorten-Vioform combinations were markedly greater than those achieved in the groups medicated with (1) Vioform 3%, (2) Locacorten 0.02%, and (3) placebo cream. Staphylococcus aureus was the most prevalent organism isolated from the skin lesions. All strains were sensitive to Vioform, as compared to 62% found to be resistant to other antimicrobials.
Investigations for Skin Antibodies in Malignant Neoplasms
Authors: Diederichsen H. , From E. , Heydenreich G.
Published: October 2009

A group of 451 patients with various malignant neoplasms was investigated for the presence of antibodies against the intercellular substance in epidermis and against the basement membrane in the skin, using the immunofluorescence method. None of the patients had bullous disease. Circulating basement membrane antibodies were found in a 63-year-old man with lung cancer. None of the patients had antibodies against the intercellular substance. No in vivo bound intercellular or basement membrane antibodies were found.
Use of Impulse Cytophotometry for Studying Cell Kinetics in a Case of Psoriasis pustulosa et arthropathica
Authors: Bauer F.W. , Mali J.W.H.
Published: October 2009

Impulse cytophotometry, a recently developed method for measuring cell constituents in single cells, was used to study cell kinetics in a case of psoriasis pustulosa et arthropathica. The profound clinical changes have their counterpart in the cell kinetics. Whereas in the active front the percentages of cells in S and mitosis are very high, they are virtually normal in the clinically healthy area just before and beyond the front. As the front moves rather fast, dramatic changes must appear at the cellular level. It is suggested that impulse cytophotometry, because of its versatility and speed, can be used in evaluating therapy by analogy to its use in cancer research (leukemia).
Ichthyosis hystrix of ‘Porcupine Man’ Type
Authors: Capetanakis J. , Stratigos J. , Tsambaos D. , Nicolis G. , Seitanidis L.
Published: October 2009

Ichthyosis hystrix is a term used to describe an ichthyosiform dermatosis in which formation of hyperkeratotic, verrucose excrescences is a prominent clinical feature. This paper deals with an interesting case of ichthyosis hystrix associated with a negative family history and two squamous cell epitheliomas.
A Case of Cutaneous Amoebiasis
Authors: Sunarwan I.
Published: October 2009

The present report concerns a patient with ulceration around an artificial anus. The condition had been treated for some time as pyoderma gangrenosum but finally proved to be cutaneous amoebiasis; the presence of Entamoeba histolytica was demonstrated. A cure was achieved with metronidazol (Flagyl®) and diloxanide furoate (Furamide®) given orally.
Pseudomonas putrefaciens as a Cause of Infection of Venous Ulcers
Authors: Degreef H. , Debois J. , Vandepitte J.
Published: October 2009

The first well-documented case of an infection of venous phlegmonous ulcers by Pseudomonas putrefaciens is presented. The significance in dermatology is discussed.
Staphylococcal Scalded Skin Syndrome in an Adult
Authors: Achten G. , de Dobbeleer G. , Moriamé N. , Gottignies P. , Kahn R. , Potvliege P.
Published: October 2009

The staphylococcal form of toxic epidermal necrolysis or staphylococcal scalded skin syndrome (SSSS) is exceptionally seen in an adult patient. We report a case of SSSS in a 21-year-old male who suffered from a fulminant pneumopathia due to a phage group II Staphylococcus aureus. The onset of that clinical picture in an adult patient is unusual and could be due to a deficient immunity, as previous case reports have emphasized. Unfortunately, the sudden death of our patient did not allow us to investigate his immunological defences.
Treatment of Melasma (Chloasma) by Local Application of a Steroid Cream
Authors: Neering H.
Published: October 2009

15 patients with melasma were treated with betamethasone 17-valerate in a cream base containing DMSO. One patient with secondary pigmentation was also entered in the trial. In nine patients results were favourable and in three results were moderate. This effect could be ascribed to the steroid.
Elimination of Circulating Antibodies
Authors: Sood V.D. , Pasricha J.S. , Kandhari K.C.
Published: October 2009

Rabbits were immunised with a fraction of normal human epidermis to produce circulating antibodies. In each experiment, half of the immunised rabbits were given a dose of the same antigen intravenously and the changes in the titres of antibodies were recorded. Doses of the antigen used in different experiments varied from 0.09 to 3.5 mg protein per rabbit (each approximately 1 kg in weight) and led to a mild decrease in the antibody titres for the first 24 h, followed by a secondary rise. Administration of corticosteroids together with the antigen intravenously could check this secondary rise in antibody titre. Repeated intravenous injections of the antigen led to severe anaphylactic reactions, while subcutaneously administered antigen produced no significant effects.
Serum Lipids in Patients with Psoriasis
Authors: Brenner S. , Krakowski A. , Levtov O. , Heldenberg D. , Werbin B. , Tamir I.
Published: October 2009

In 13 patients with psoriasis a lower total cholesterol (TC) concentration was found compared to healthy controls of the same population. No differences in the concentration of serum triglyceride (TG) or phospholipids (PL) were detected between these two groups. In the same patients, serum triglyceride fatty acid analyses showed a reduced concentration of linoleic acid and a raised level of palmitoleic and myristic acids. No differences were detected in the major phospholipid fractions. The increase in plasma free fatty acids (FFA) following intravenous heparin was comparable in the psoriatic patients and in the controls. It is concluded that no basic abnormality of serum lipids exists and that the changes described were due to a selective loss via the scales or due to malabsorption.
Influence of Local Triamcinolone Acetonide on Patch Test Reactions to Nickel Sulfate
Authors: Smeenk G.
Published: October 2009

The influence of local application of triamcinolone acetonide on patch test reactions was investigated in patients with a contact allergy to nickel sulfate. In 15 patients the reaction to patch tests with a mixture of 5% nickel sulfate and 0.1% triamcinolone acetonide in petrolatum was compared with the reaction to 5% nickel sulfate in petrolatum. In eight patients the test area on the skin was infiltrated with triamcinolone acetonide or saline solution after which tests were performed with nickel sulfate. In eight patients the test area was pretreated with 0.1 % triamcinolone acetonide cream or the cream base alone before the patch tests with nickel sulfate were done. In general, all three methods gave partial suppression of the size of the reaction.
Visken as Supplementary Drug in the Treatment of Pemphigus
Authors: Chorzelski Tadeusz , Jablonska Stefania , Maciejowska Ewa , Blaszczyk Maria
Published: October 2009

Results of combined treatment with low doses of steroids (50–10–5 mg) and Visken (7.5–15 mg) in 5 cases of pemphigus erythematosus and 5 cases of pemphigus vulgaris are presented. Treatment lasted from 30 days to 1.5 years. Some of the patients had been previously treated with steroids and immunosuppressive drugs, but had active lesions or frequent recurrences. In pemphigus erythematosus, very good results were obtained in 3 of 5 cases, and failure in 2 cases was probably related to insufficient dosage of steroids, or no treatment with steroids at all. In pemphigus vulgaris results were not satisfactory. Visken can serve as a supplementary drug in the treatment of pemphigus erythematosus. No complications were observed, and the drug may be regarded as safe.
Ultrastructural Evolution of the Skin in Incontinentia pigmenti (Bloch-Sulzberger)
Authors: Guerrier C.J. , Wong C.K.
Published: October 2009

The skin of six cases of incontinentia pigmenti was studied electron microscopically. The patients ranged from 9 days to 34 years of age and included one male. Ultrastructural alterations observed confirmed the clinical staging of the disease. Early in the illness both deposition of melanin into the dermis by epidermal melanocytes and an abnormal population of melanocytes high in the epidermis were noted. Also deposition of melanin in Schwann cells was seen. With the passage of time there was first dysfunction and finally atrophy of melanocytes and dispersal of the dermal deposits of melanin.
Subcutaneous Nodular Sarcoid
Authors: Clayton Roger , Wood Peter
Published: October 2009

A case of subcutaneous nodular sarcoid in a Negro is described. There were no other dermatological manifestations. This appears to be the third such case described in the English literature. Treatment with prednisone resulted in complete resolution of the nodules in 6 weeks.
Dermatofibrosarcoma protuberans mit Übergang in ein sogenanntes Fibrosarkom
Authors: Hagedorn M. , Thomas C. , von Kannen W.
Published: October 2009

Report on a case of dermatofibrosarcoma protuberans that was observed clinically and histologically for 15 years. During the course of the disease seven recurrences occurred being characterized by an increasing tendency for malignancy. The tumours showed an increasing number of densely packed cells and revealed a predominantly infiltrating growth, which finally lead to the diagnosis of fibrosarcoma in the latest stage of the disease.
Low Alkali Resistance and Slow Alkali Neutralization
Authors: Björnberg A.
Published: October 2009

In testing carefully selected and matched series of patients with hand eczema and their controls it was concluded that: (1) patients with healed hand eczema had a normal alkali neutralization and a normal alkali resistance on their legs, provided the eczema was healed. Therefore, the value of these tests in pre-employment testings to find ‘eczematous subjects’ could not be confirmed. (2) Patients with active eczema limited to the hands have a normal alkali neutralization and alkali resistance tests on their legs. This is relevant to ‘alkali eczema’. However, when the eczema involves other areas besides the hands, the alkali resistance test done on the normal looking skin of the legs is lowered. This seems to be due to a general non-specific increased skin reactivity to irritants which is provoked by the presence of the active eczema – ‘status eczematicus’. Testing with other irritants (sodium lauryl sulphate, hydrochloric acid, benzalkonium chloride, croton oil, and sapo kalinus) showed a parallel-increased skin reactivity.
Shoe Dermatitis in Greece
Authors: Varelzides A. , Katsambas A. , Georgala S. , Capetanakis J.
Published: October 2009

25 female patients with shoe dermatitis were studied. The most frequent cause of the sensitization appeared to be chromic salts, which are mainly used in the tanning process in Greece. Rubber sensitivity is the second cause of shoe dermatitis, tending to assume the first position because of the continuous increase in the use of rubber shoes in Greece.
Leishmaniasis tegumentaria sudamericana im Gebiet des Rio Pachitea
Authors: Heimgartner E. , Heimgartner V.
Published: October 2009

During a 1-year epidemiological investigation of the mucocutaneous leishmaniasis in the endemic area round the Rio Pachitea (Peruvian virgin forest, catchment area of the upper Rio Ucayali), we diagnosed 120 cases of leishmaniasis tegumentaria sudamericana (Espundia). Of these cases 27 were treated at the local tropical medicine clinic at Puerto Inca: 6 of them received stibophen, and 21 of them stibophen, and 21 of them amphotericin B. The treatment of leishmaniasis tegumentaria sudamericana with amphotericin B is discussed in detail. The use of stibophen is confined to fresh skin ulcers, while amphotericin B is the only drug known to date that holds out hope of success in all mucocutaneous and chronic forms of the disease.
Annular Atrophic Plaques of the Face. An Entity or an Annular Atrophic Discoid Lupus erythematosus?
Authors: Jablonska S. , Chorzelski T. , Mazurkiewicz W.
Published: October 2009

The paper describes a case corresponding clinically and histologically to annular atrophic plaques of the face and resembling lichen sclerosus et atrophicus, morphea, and discoid lupus erythematosus (DLE). Immunopathological investigations were twice negative but afterwards revealed profuse immunoglobulin and complement deposits at the epidermal-dermal junction in the lesions both of the face and scalp, which became involved only lately. Raynaud’s syndrome of considerable intensity and then incipient abortive acroscleroderma without systemic involvement developed in the course of the 10 years of observation. The authors believe that annular atrophic plaques may be really a variety of DLE in subjects with pronounced vascular changes and a tendency for dermal sclerosis, which endow the condition with a sclerodermiform character.
Fotosensitization by Amantadine (Symmetrel®)
Authors: van Ketel W.G. , Dijk Goedhart-van
Published: October 2009

A 60-year-old female patient, suffering from Parkinson’s disease, is described with an eruption caused by Amantadine (1-amino-adamantane), which is the result of photosensitization.
Chronisch polymorphe Lichtdermatose
Authors: Jung E.G. , Bohnert E.
Published: October 2009

Peripheral blood lymphocytes of patients with chronic polymorphic light eruption (n = 33) show a normal blastogenic transformation after PHA stimulation. The excision repair mechanism is unaltered. There is no evident difference between lymphocytes taken during light eruption and those taken in an interval. A correlation to the level of IgE is not demonstrable.
Blunted Fasting-Induced Hypothalamic Activation and Refeeding Hyperphagia in Late-Onset Obesity
Authors: Becskei Csilla , Lutz Thomas A. , Riediger Thomas
Published: October 2009

Hormonal and metabolic factors signal the status of energy balance to hypothalamic nuclei. Obesity is characterized by neuronal, metabolic and hormonal alterations. We therefore hypothesized that hypothalamic responses to challenges of energy balance may differ between lean and obese animals. To test this, we compared c-Fos expression in the hypothalamic arcuate (ARC) and paraventricular nuclei (PVN) and the lateral hypothalamic area (LHA) of mice (1-year-old) with late-onset obesity (LOO) and of lean controls under different feeding conditions. Fourteen hours of fasting induced high c-Fos expression in neuropeptide-Y-positive ARC neurons, in the PVN and in the rostral LHA in lean but not in LOO mice. c-Fos expression in melanin-concentrating hormone (MCH) and orexin-containing neurons in the caudal LHA was not affected by fasting. LOO mice showed fasting hyperinsulinemia, hyperleptinemia, elevated fasting blood glucose and an attenuated hyperphagic response during refeeding. Moreover, the anorectic response to leptin and hypoglycemic response to insulin were reduced in LOO mice. We conclude that adiposity blunts the neuronal responses to metabolic challenges in hypothalamic centers which control feeding behavior and energy balance. Elevated blood glucose may be one factor that suppresses hypothalamic responsiveness in obese mice. A similar impact of hyperinsulinemia and hyperleptinemia in LOO mice is also likely although under the current experimental conditions responsiveness to some effects of these hormones appeared to be reduced.
Mitteilungen – Communications Zur Behandlung des Lyell-Syndroms
Authors: Gutzwiller P. , Schuppli R.
Published: October 2009

Report on 8 patients with toxic epidermal necrolysis, in whom, although drugs could be incriminated as causative agents, infectious processes were found. The authors point out that in this disease infections have to be looked for and treated. A too intensive therapy with corticosteroids should be avoided.
Elektronenoptische Faserstrukturen beim Skleromyxödem und beim Skleroedema adultorum
Authors: Pilgrim U. , Vogel A. , Meves C.
Published: October 2009

Skin biopsies of scleromyxedema and scleredema adultorum were studied with the electron microscope in the stratum papillare and upper stratum reticulare with special reference to changes of the collagen fibril diameter. In scleromyxedema the structural alterations corresponded with the duration and clinical course of the disease. The importance of fibril neogenesis, impaired maturation or accelerated ageing of the collagen fibril is discussed. In scleredema adultorum the histogram of the fibril diameter is shifted towards smaller values, indicating that the metabolism of scleroproteins is implicated in the disease.
The Therapeutic Value of Retinoic Acid (Vitamin A Acid) in Lichen Planus of the Oral Mucous Membrane
Authors: Günther S.
Published: October 2009

Eleven patients with hypertrophic and one patient with atrophic lichen planus of the oral mucosa were treated using retinoic acid (vitamin A acid) in different forms of administration. The most satisfactory results have been obtained in asymptomatic cases showing a plaquelike hypertrophic appearance on the buccal mucosa. The possibleside effects of such treatment are mentioned.
Granuloma fissuratum of the Ears Lasting 20 Years
Authors: Kocsard E.
Published: October 2009

Chronic infection and dermal sensitivity to metals are important factors in the pathogenesis of granuloma físsuratum. The primary event is probably the fissure which may be due to the spectacle frames or to post-auricular seborrhoeic dermatitis.
Lichen ruber planus mit Onychatrophie und narbiger Alopezie
Authors: Ebner H.
Published: October 2009

Case report of a 63-year-old female with lichen planus. In addition to the typical, papular skin and mucosal lesions, bullous-ulcerative changes with onychatrophy were present on the feet, as well as follicular papules with cicatricial alopecia. This rare form of lichen planus, which occurs especially in women, is discussed.
Erythropoietic Protoporphyria
Authors: Bhutani L.K. , Deshpande S.G.
Published: October 2009

A second patient with erythropoietic protoporphyria (EPP) from India is reported. Unusual features in this patient were high degree of photosensitivity and marked hypertrichosis. The probable cause of hypertrichosis and its relationship to sunlight is discussed.
Atypical Primary Syphilitic Lesions on the Penis
Authors: Notowicz A. , Menke H.E.
Published: October 2009

An increase in number of patients with an atypical clinical picture of syphilitic primary lesions on the penis is mentioned in the literature. The figures generally agree with the findings of 87 male patients with primary syphilis examined at the Department for Skin and Venereal Diseases of the University Hospital Rotterdam-Dijkzigt. Some possible reasons for the occurrence of atypical primary syphilis are mentioned. In contrast with some other authors, in our series we could not find arguments in favour of the hypothesis that previously received local or systemic treatment increased the rate of atypical primary syphilis.
Sensibilisations cutanées allergiques peu communes
Authors: Reiffers J. , Hunziker N. , Brun R. , Vidmar B.
Published: October 2009

Eight cases are described: four of contact dermatitis caused by nickel in children, one in a young boy caused by hexavalent chromium, and three cases in children also caused by phenyl mercuric borate. In addition, one case of contact sensitization in a mother and her child to p-hydroxybenzoic acid esters (paraben) and one case of immediate-type reaction to application of a patch test with ammonium persulfate are described.
Topical Treatment of Cutaneous Candidiasis with 5-Fluorocytosine Compared with Nystatin
Authors: Gisslén H. , Hersle K. , Mobacken H.
Published: October 2009

30 patients with symmetrical intertriginous candidiasis were treated with 5-fluorocytosine 10% cream and nystatin gel using the paired comparison method. The agents were applied twice daily for 2 weeks. Both compounds were equally effective in eradicating C. albicans and in clinical effectiveness. No side effects were recorded.
Agranulocytosis during Dapsone Administration
Authors: ten Broeke J.E. , Cunningham L.D.
Published: October 2009

Fatal agranulocytosis developed during treatment of a patient with dermatitis herpetiformis. Although he received other medications, dapsone was considered the probable cause of the agranulocytosis. Recent reports have documented the occurrence of dapsone-induced agranulocytosis during malaria prophylaxis. The present case emphasizes the possibility of this serious and sometimes fatal complication arising during sulfone therapy of dermatologicdisorders.
Photodermatitis Induced by Chlorpropamide
Authors: Feuerman E. , Frumkin A.
Published: October 2009

Five diabetic patients developed photodermatitis following the ingestion of 250–500 mg chlorpropamide per day, from 3 weeks to 4 years after the onset of therapy. Four patients developed the rash in August and September and one in December. Four patients were treated successfully by withdrawing chlorpropamide, shielding from sunlight and administering local symptomatic therapy, while the fifth patient had to be given corticosteroids. In four patients, the skin ultimately cleared, but one patient developed a residual leukomelanoderma. In one patient the minimal erythema dose was found to be lowered a few hours after ingesting a small dose of chlorpropamide.
Demonstration of Intercellular and Basement-Membrane Zone Antibodies in Benign Prostatic Hypertrophy
Authors: Ablin R.J.
Published: October 2009

Low titers of antibodies reactive with an antigen present in the intercellular (IC) areas and basement-membrane zone (BMZ) of stratified squamous epithelium were observed in the serum of 26% (11 of 42) and 7% (3 of 42) patients with benign prostatic hypertrophy, respectively, by the method of indirect immunofluorescence (IF). IC IF staining could be differentiated from similar IF patterns which are obtainable with sera from individuals with high titers of blood group isohemagglutinins by their stability following absorption with blood group-specific substances A and B. The finding of BMZ antibodies was particularly interesting in view of the suggested association of manifestations of bullous pemphigoid and the occurrence of internal malignancy.
Aspergillosis of the Skin
Authors: Caro I. , Dogliotti M.
Published: October 2009

Aspergillosis is an opportunistic infection. It usually involves the lungs, but rarely involves the skin. An example of cutaneous involvement is presented. AspergiUosis as a cause of granulomatous lesions in debilitated patients is discussed.
Erythrodermatische Hauthistoplasmose
Authors: Cramer H.J.
Published: October 2009

A 28-year-old man presented with an exfoliative dermatitis transforming into a chronic generalized erythroderma of unknown etiology. Later, when he started to develop skin ulcerations, it was felt that they represented a progression of a mycosis fungoides. The patient died of pulmonal embolies. The autopsy showed no signs of a systemic or another internal disease. After death, it was possible to secure the diagnosis of histoplasmosis in the skin biopsies. In conclusion, we suggest the diagnosis of histoplasmosis to be considered in all cases of exfoliative dermatitis of unknown etiology.