Comparative analysis of the clinical outcomes between wavefront-guided and conventional femtosecond LASIK in myopia and myopia astigmatism
Authors:   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Gui Xiao , Li Sha ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Zhao Na ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Zhang Hao-Rui ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Zhou Yu-Kun ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Huan Chen-Yang ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Zhao Chun-Yan ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Wang Hong-Ying ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Song Hong-Yuan ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China, Shen Wei ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China, Zhang Jian-Hua ,   Department of Ophthalmology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
Published: September 2021

AIM: To compare the clinical outcomes of wavefront guided femtosecond LASIK (WFG LASIK) and conventional femtosecond LASIK (NWFG LASIK) in eyes with myopia and myopia astigmatism.
METHODS: This was a retrospective, nonrandomized, comparative investigation enrolling 236 eyes of 122 patients (18-50y) with low & moderate and high myopia. The WFG group including 97 eyes (50 patients) undergone WFG LASIK and the NWFG group including 139 eyes (72 patients) undergone conventional LASIK. Mean efficacy index, high order aberrations (HOAs), pupil size and the quality of visual questionnaire were evaluated 6mo postoperatively.
RESULTS: There is no difference between WFG group (-0.054±0.049 in logMAR) and NWFG group (-0.040±0.056) in uncorrected distance visual acuity (UDVA) postoperatively. The myopia astigmatism is higher in WFG group than that in NWFG group (P<0.05). However, the mean efficacy index (MEI) in the WFG group (1.09±0.106) is better than that in the NWFG group (1.036±0.124; P<0.001). Increased HOAs were observed in NWFG group (0.30±0.196) than that in WFG group (0.146±0.188; P<0.001). The pupil size is larger in WFG group (5.15±0.76 mm) than that in NWFG group (4.32±0.52 mm). The patients are satisfied with the clinical surgery, yet WFG group showed better visual quality using the questionnaire survey. Meanwhile, high myopia would result in worse MEI, HOAs and visual quality than low & moderate myopia.
CONCLUSION: WFG and NWFG FS-LASIK are both effective and safe procedures to correct low & moderate and high myopia, but WFG FS-LASIK gives a better postoperative MEI, aberrometric control and predictable outcome. Meanwhile, WFG FS-LASIK is better than NWFG FS-LASIK in correction of myopia astigmatism. Low & moderate myopia allow better clinical outcomes than high myopia using any surgical method.