bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune Thrombocytopenia Purpura
Authors: Kamat Deepak M.
Published: November 2021

Key Points

Two Types: Acute and Chronic Diagnosis: Established by excluding known causes of thrombocytopenia Treatment: Depends on the platelet count and the presence and severity of bleeding. When therapy is indicated, the primary treatment options for the newly diagnosed patient are: Corticosteroids Intravenous immunoglobulin Intravenous anti-D Ig
Lyme Disease
Authors: Joerger Torsten
Published: November 2021

Key Points

Lyme disease affects an estimated 300,000 people per year in the United States. Lyme disease is divided into Early disease (erythema migrans [EM]) Early disseminated disease (multiple EM lesions, Bell palsy, meningitis, carditis) Late disease (arthritis) EM should be diagnosed clinically, as laboratory test results may be negative. Serology should be considered for the diagnosis of disseminated or late disease only in children with compatible clinical symptoms. Lyme disease has an excellent prognosis if treated with appropriate antibiotics.
Meningococcemia
Authors: Joerger Torsten
Published: November 2021

Key Points

Meningococcemia occurs when the bacteria Neisseria meningitidis enters the bloodstream and causes sepsis. Meningococcemia is rare but has a high mortality rate. Risk factors for meningococcemia include age younger than 1 year, living in crowded conditions, and complement deficiencies. Vaccines do not prevent infection from all serogroups of N meningitidis but are an important tool to decrease the risk of invasive infection. Close contacts of patients with invasive meningococcal disease should receive chemoprophylaxis.
Speech and Language Concerns
Authors: Adam Henry
Published: November 2021

Key Points

Speech and language delays are probably the most common developmental concern parents have about young children.Delays in speech and language are often the first indication of a broader development delay or disability.Hearing loss is an important consideration in any child with delayed or disordered speech and language.Timely evaluation and intervention can mitigate long-term consequences.
Disruptive Behavior and Aggression
Authors: Wissow Lawrence S.
Published: November 2021

Key Points

All children are defiant at times, and acting out may be the only way a child knows to communicate distress; by examining the antecedent, behavior, and consequence, a clinician may uncover a basic need (eg, safety, food, love) that is unmet.Disruptive or aggressive behavior may be a symptom of many different mental health problems and may be a response to traumatic experience(s); oppositional defiant disorder (ODD) or conduct disorder (CD) may be present if behaviors such as marked tantrums, fighting, bullying, and disciplinary actions by child care or schoolAre repetitive and excessive.Are out of keeping with developmental and social norms.Persist rather than appearing briefly as part of adaptation to a new situation or developmental period.Interfere with family life, school, or peer relationships.Put the child or others in danger.Standardized psychosocial screening instruments and collateral reports from child care or school are useful in identifying symptoms of disruptive behavior or aggression.Parents of children with oppositional behavior can become chronically angry and depressed, which can reinforce the negative environment and attention, perpetuating a cycle of opposition.Evaluation requires differentiating it from typical behavior, understanding the context of misbehaviors, distinguishing between impulsive and premeditated patterns of behavior, identifying adversities or loss that preceded the behaviors, and recognizing conditions (eg, sleep deprivation, learning difficulties, anxiety, depression) that may mimic or co-occur with disruptive and aggressive behaviors.Pediatric clinicians can provide meaningful intervention, even in the absence of a diagnosis, through expressions of hope, empathy, and support to the youth and family; by promoting daily positive joint activities between parents and the child or teen; and by coaching parents in effective behavioral management using positive reinforcement techniques, derived from evidence-based parenting programs.Refer for evaluation by and comanagement with mental health specialist(s) ifBehaviors are injurious to other children or animals.Symptoms developed following traumatic experience or loss.Symptoms suggest ODD or CD.The child manifests severe dysfunction in any domain.Symptoms persist or worsen despite pediatric interventions.Comorbidities include depression, anxiety, or substance use.The family is not able to maintain a calm, consistent, or safe environment.The youth is involved with legal authorities.The pediatric clinician is considering medication.
Papulosquamous Disease
Authors: Bode Sara
Published: November 2021

Key Points

Papulosquamous skin diseases includePsoriasisPityriasis roseaPityriasis lichenoidesPityriasis rubra pilarisLichen planusLichen nitidusLichen striatusAll these conditions are often diagnosed clinically but occasionally need biopsy for confirming the diagnosis.All conditions except psoriasis and lichen planus undergo spontaneous resolution and need just supportive care.Patients suspected of having psoriasis and lichen planus may need to be referred to a dermatologist for further evaluation and management.
Guillain-Barré Syndrome
Authors: Sivaswamy Lalitha
Published: November 2021

Key Points

Guillain-Barré syndrome (GBS) is a group of acquired, immune-mediated conditions affecting peripheral nerves and nerve roots.Guillain-Barré syndrome is the most common cause of acute flaccid paralysis in childhood.The most common age-group affected by GBS is 4 through 8 years.One-half to two-thirds of cases manifest as a postinfectious illness 1 to 3 weeks after infection.Most evidence linking GBS to vaccines is temporal and causality has not been established clearly.Diagnosis is primarily based on a constellation of typical symptoms, neurologic signs, and paraclinical findings with exclusion of relevant differential.Laboratory and electrophysiological testing are important to establish diagnosis.Consensus on the basis of case series and retrospective analysis indicates that intravenous immunoglobulin can reduce duration of hospitalization and time to ambulation.
Perfil da imigração africana no Brasil durante o governo Dilma Rousseff (2011-2016): o caso dos senegaleses e oeste-africanos
Authors: Roberto Rodolfo  Georg-Uebel
Published: November 2021

Este artigo, que é resultado de tese doutoral no campo dos Estudos Estratégicos Internacionais, tem como objetivo discutir e analisar crítica e cartograficamente as migrações internacionais africanas para o Brasil durante o governo de Dilma Rousseff (2011-2016). O texto também realiza uma discussão sobre o caso específico dos fluxos de senegaleses e demais grupos oeste-africanos e a sua inserção na sociedade brasileira à luz dos elementos de agregação social, tratamento estatal e perspectivas ante à nova Lei de Migração.
Low-level pathogen transmission from wild to farmed salmonids in a flow-through fish farm
Authors: Pravdová Markéta , Ondračková Markéta , Palíková Miroslava , Papežíková Ivana , Kvach Yuriy , Jurajda Pavel , Bartáková Veronika , Seidlová Veronika , Němcová Monika , Mareš Jan
Published: November 2021

While the potential effects of pathogens spread from farmed fish to wild populations have frequently been studied, evidence for the transmission of parasites from wild to farmed fish is scarce. In the present study, we evaluated natural bacterial and parasitic infections in brown trout (Salmo trutta m. fario) collected from the Černá Opava river (Czech Republic) as a potential source of infections for rainbow trout (Oncorhynchus mykiss) reared in a flow-through farm system fed by the same river. The prevalence of bacterial and protozoan infections in farmed fish was comparable, or higher, than for riverine fish. Despite this, none of the infected farmed fish showed any signs of severe diseases. Substantial differences in metazoan parasite infections were observed between wild and farmed fish regarding monogeneans, adult trematodes, nematodes, the myxozoan Tetracapsuloides bryosalmonae found in riverine fish only, and larval eye-fluke trematodes sporadically found in farmed fish. The different distribution of metazoan parasites between brown and rainbow trout most probably reflects the availability of infected intermediate hosts in the two habitats. Despite the river being the main water source for the farm, there was no significant threat of parasite infection to the farmed fish from naturally infected riverine fish.
Validated chromatographic methods for the simultaneous determination of a ternary mixture of sulfacetamide sodium and two of its official impurities; sulfanilamide and dapsone
Authors: El-Ragehy Nariman A. , Hegazy Maha A. , Tawfik Samia A. , Sedik Ghada A.
Published: November 2021

Sulfacetamide sodium is a widely prescribed sulfonamide drug due to its topical antibacterial action on eye and skin. Four impurities are stated in the British Pharmacopoeia among which are sulfanilamide and dapsone. This work presents two specific, accurate and precise chromatographic methods for the simultaneous determination of a mixture of sulfacetamide sodium, sulfanilamide and dapsone. The first method is an isocratic RP-HPLC where the separation of components was achieved on C18 column. A green mobile phase was used consisting of methanol:water (60:40, v/v). The flow rate was 1.0 mL/min and effluent was monitored at 273 nm. The second method is a TLC-spectrodensitometric one where good separation was achieved by using silica plates and a mobile phase consisting of chloroform:dichloromethane:acetic acid (6:2.5:1.5, by volume). Determination was done by densitometry in the absorbance mode at 273 nm. Both methods were validated in compliance with ICH guidelines. They were also successfully applied for the determination of sulfacetamide sodium and its impurities in Ocusol® ophthalmic solutions. The obtained results were statistically compared to the results obtained by applying the official methods of analysis of each component where no significant difference was found with respect to accuracy and precision.
Algunas propuestas para comprender el aspecto político del pontificado de san Juan Pablo II
Authors: Skibiński Paweł
Published: November 2021

Aunque el Papa no fue un político, el pontificado de Juan Pablo II tuvo su aspecto político. Para definir esa dimensión de su pontificado mencionaremos cuatro elementos esenciales: a) el impacto papal en la política de los Estados; b) su participación en la formación de las relaciones internacionales; c) el impacto de Juan Pablo II en el desarrollo de la libertad religiosa; y d) la inspiración religiosa personal de los políticos. El papa polaco influyó especialmente en el inicio del proceso de desmantelamiento del bloque soviético después de 1989 y en la naturaleza pacífica de estos cambios.
Kaempferol protects rats with severe acute pancreatitis through regulating NF-κB and Keap1–Nrf2 signaling pathway
Authors: Cai Jun , Yao Suyan , Wang Hao , Rong Wei
Published: November 2021

Kaempferol (KF) is an important natural anti-inflammatory flavonol. Acute pancreatitis (AP) is an inflammatory disorder, which in about 20% cases may develop into severe acute pancreatitis (SAP) with a high mortality rate. This research was to study the effects and mechanism of kaempferol on SAP. SAP was induced by sodium taurocholate. The level of cytokines was analyzed by enzyme-linked-immunosorbent serologic assay. The expression of nuclear factor kappa B (NF-κB) and Kelch-like ECH-associated protein 1–nuclear factor erythroid 2-related factor 2 (Keap1–Nrf2) proteins was analyzed by Western blot assay. Pathological changes in the pancreas were evaluated by hematoxylin and eosin staining. Kaempferol attenuated pancreatic injury in SAP rats, including reduction in inflammatory infiltration and necrosis. The level of serum amylase and lipase was also decreased in kaempferol-treated SAP rats. Kaempferol inhibited the expression of inflammatory mediators (nuclear factor-α, Interlukin-1β, and Interlukin-6), and alleviated the oxidative stress characterized by the decreased malondialdehyde (MDA) and increased superoxide dismutase (SOD) levels. Kaempferol decreased the expression of cleaved caspase 3 and anti-apoptotic protein Bcl-2, which indicated that kaempferol could inhibit apoptosis of pancreatic cells in SAP rats. Kaempferol treatment could decrease the expression of p-p65 and the amount of nuclear Nrf2 (Nu-Nrf2), which demonstrated that kaempferol inhibited the NF-κB activation and enhanced the Keap1–Nrf2 pathway. Our research indicated that kaempferol could attenuate the pancreatic injury of SAP by regulating NF-κB and Keap1–Nrf2 signaling pathway. Kaempferol could serve as a natural candidate for treating SAP.
Effect of thermal treatment on physicochemical, phytochemical, and microbiological characteristics of brown Spanish onion paste
Authors: Naqash S. , Naik H. R. , Hussain S. Z. , Makroo H. A. , Dar B. N.
Published: November 2021

Onion paste is a commercially used processed product that reduces cooking time. Industrial processing of onion paste involves various treatments that affect the overall nutritional profile of the final product. In this study, effect of various thermal treatment conditions was evaluated, with temperature and time ranging between 70 and 90°C for 8 to 22 min, respectively. Changes in quercetin, pyruvic acid, and quality characteristics of fresh onion paste were investigated. A negative linear trend was observed in quercetin, pyruvic acid, viscosity, ascorbic acid, and total plate count, with an increase in temperature and time. An interactive and combined effect of time and temperature showed a positive linear relationship with color difference. For all the quality parameters investigated in this study, thermal treatment at 87°C for 15 min was found to be optimum for development of shelf-stable onion paste. Quercetin and pyruvic acid content were found to be 2.587±0.03 g kg–1 and 0.086±0.004 µmol kg–1, respectively. Optimum conditions depicted better retention of principal compounds as compared to the other experimental conditions and exhibited safer quality product as compared to the untreated sample.
Kardynał Giovanni Antonio Davia (Gianantonio De Via) ‒ nuncjusz w Rzeczypospolitej (1696-1700)
Authors: Kęder Wojciech
Published: November 2021

W latach 1696-1700 nuncjuszem w Rzeczypospolitej był Giovanni Antonio Davia, późniejszy kardynał. Na okres jego misji przypadło szereg skomplikowanych problemów wewnętrznych jak i zewnętrznych, jakie trapiły Rzeczypospolitą: wojny tureckie, relacje katolików z innowiercami w Polsce, konflikty polityczne na Litwie, które zakończyły się wojną domową. Do bardzo interesujących należy wątek ewentualnego udziału Giovanniego Antonio Davii w elekcji na króla Polski Fryderyka Augusta Wettyna, którego panowanie miało tak fatalne skutki dla Rzeczypospolitej. Davia oskarżany był o sprzyjanie saskiej kandydaturze przez dyplomatów francuskich i ich stronników w Polsce, gdyż elektorowi saskiemu zawdzięczał uwolnienie bratanka Giovanniego Battisty z niewoli tureckiej, o co rodzina Daviów bardzo zabiegała. Nie ma bezpośrednich dowodów na złamanie przez nuncjusza Davię neutralności w elekcji, a pozostają jedynie oskarżenia przeciwników Wettyna.
Losy polskich żołnierzy ery napoleońskiej w świetle kazań i mów okolicznościowych z okresu Księstwa Warszawskiego i Królestwa Polskiego
Authors: Szczurowski Rafał
Published: November 2021

Po 1795 r., po upadku państwa, Polacy, aby je odzyskać, musieli chwycić za broń i walczyć o niepodległość. O tej walce dowiedzieć się można było również z kazań i mów okolicznościowych czasów Księstwa Warszawskiego i Królestwa Polskiego, wygłaszanych na pogrzebach, przed rozpoczęciem obrad sejmu, na nabożeństwach z udziałem wojska oraz uroczystościach organizowanych ku czci panujących. Ich autorzy, duchowni, opowiadali o doświadczeniu polskiego żołnierza, jakim była bohaterska walka w różnych częściach świata pod przewodem Napoleona Bonapartego, a która to walka miała doprowadzić do wskrzeszenia Polski. Zarazem kaznodzieje przedstawiali rodzimych żołnierzy doby napoleońskiej, jako dziedziców staropolskiego męstwa i bojowników narodowej sprawy, których wzorcowym reprezentantem stawał się książę Józef Poniatowski. Postać zaś i losy księcia, jak i jego współtowarzyszy broni, utrwalone przez legendę napoleońską, będą inspirowały następne pokolenia walczące o wolność Polski.
Argumentacja Soboru Nicejskiego II za kultem ikon
Authors: Gilski Marek
Published: November 2021

Artykuł prezentuje argumentację za kultem ikon przedstawioną w czasie obrad Soboru Nicejskiego II. Argumenty mają charakter teologiczny, filozoficzny, socjologiczny i logiczny. Spośród jedenastu przytoczonych argumentów najwięcej miejsca w aktach soborowych zajmuje opis cudów dokonanych za pośrednictwem ikon.
Pasyjne fenomeny mistyczne
Authors: Rachwalik Walter
Published: November 2021

W doświadczeniach mistyków Kościoła ważne miejsce zajmuje fakt ich partycypacji w Męce Jezusa Chrystusa. Mistycy mogą otrzymać dary niewidzialnego przebicia serca i niewidzialnych stygmatów, również widzialnego udziału w biczowaniu, w ukoronowaniu cierniem i w ukrzyżowaniu Zbawiciela, co przyjmuje formę faktycznego przebicia ich dłoni, stóp i serca. Dopełnieniem są zjawiska krwawego potu i krwawych obraz i napisów. Tak więc fenomeny pasyjne im udzielone są rzeczywistym odbiciem tajemnic Golgoty. Ich życie przybiera formę żywej księgi pamięci o cenie Zbawienia, którą Jezus Chrystus zapłacił na drzewie Krzyża.
Stanowisko pierwszych brytyjskich emergentystów wobec teorii ewolucji
Authors: Sadłocha Łukasz
Published: November 2021

W XIX wieku teoria ewolucji nie była jeszcze powszechnie przyjmowana i dopiero upowszechniała się w środowisku naukowym, a tym samym i wśród brytyjskich emergentystów. Pierwszymi przedstawicielami nurtu emergentyzmu brytyjskiego są John Stuart Mill oraz George Henry Lewes. Mill uważany jest za ojca tego kierunku, a Lewesowi zawdzięcza się ukucie terminu emergentny na określenie, tego, co Mill nazywał skutkiem heteropatycznym. Celem tego artykułu jest ukazanie odmiennego podejścia Milla i Lewesa do teorii ewolucji, a tym samym do emergentyzmu.
Życie i działalność ks. Stanisława Sikorskiego (1910–1993)
Authors: Sałaj Bartosz
Published: November 2021

Niniejszy artykuł jest próbą syntetycznego opracowania monografii radomskiego kapłana. Analiza polegała na chronologicznym odtworzeniu poszczególnych etapów życia ks. Sikorskiego zgodnie z zebranym materiałem źródłowym. W pracy przedstawiono środowisko, z którego wyrósł, oraz scharakteryzowano pierwsze miejsca jego pracy kapłańskiej na wikariatach i posługę kapelana oddziałów partyzanckich AK. Omówiono okres probostwa w Głowaczowie wraz ze specyfiką prowadzonego duszpasterstwa, odbudową kościoła parafialnego oraz kontaktami z władzą państwową. W dalszej części ukazano działalność proboszcza w radomskiej parafii św. Jana Chrzciciela, opisano duszpasterstwo, wysiłki, które ks. Sikorski podejmował na rzecz powstawania nowych obiektów sakralnych w Radomiu, oraz postawę, jaką prezentował, pełniąc funkcję dziekana radomskiego. W pracy wykorzystano kościelne i państwowe źródła archiwalne oraz dostępne opracowania.
Medya sektöründe Sanayi 4.0 uygulaması: TRT örneği
Authors: Toksoy Beyza , Uzunay Birol
Published: November 2021

Medya sektöründe, yayın üretim teknikleri hızla değişmektedir. Bu değişiklikler, önce küreselleşme ve dijitalleşmenin etkisiyle oluşmuştur. Daha sonra sanayi 4.0 üretim tekniklerinin alt yapısı medyada uygulanmaya başlamıştır.
Sanayi 4.0 sürecini öngörerek alt yapılarını hazırlayan medya şirketlerinin, yüksek düzeyde rekabet gücü kazanabilecekleri yorumlanmaktadır. Türkiye’deki özel sektör medya şirketlerinin ve kamu yayın kurumlarının; Sanayi 4.0'a yatırım yaparak, yayın üretimlerini buna göre ayarlamalarının bir tercih değil zorunluluk olduğu öngörülmektedir.
Bu makalenin saha araştırılmasında Türkiye Radyo Televizyon Kurumu’nun (TRT) seçilmesinin nedeni, bir kamu kurumu olarak son 12 yılda dijital teknolojiye yaptığı yatırımlardır. Ayrıca TRT’nin küreselleşme uyumu için yapılan idari, mali ve teknik yatırımları önemli bulunmaktadır. TRT, yayın politikalarıyla kamuoyunda çok eleştirilse de  küreselleşme uyum çalışmaları ve dijitalleşme yatırımlarıyla özel sektör yayın işletmelerinin ve diğer kamu kurumlarının önüne geçtiği öngörülmektedir.
Çalışma bir yayın kurumunda, Sanayi 4.0 teknolojilerinin nasıl uygulanabileceğini gösteren düzenlemelere örnek teşkil etmesi amacıyla yapılmıştır. Bu amaçla TRT kurumunun Sanayi 4.0 alt yapı yatırımları; literatür, saha araştırması ve yapılan röportajlarla incelenmiştir. Röportaj yapılan TRT uzmanları A1, A2 ve A3 olarak belirtilmiştir.
Energy consumption, economic development and environmental degradation nexus for Nigeria
Authors: Ashibi Ushie David , Ranmilowo Aderinto Esther
Published: November 2021

This study tests the existence of the Environmental Kuznets Curve (EKC) hypothesis for Nigeria using two environmental indicators vis-à-vis ecological footprint and carbon dioxide emissions. Data was sourced from World Development Indicators (WDI) and the Global Footprint Network for the period spanning from 1981 to 2019.The Auto Regressive Distributed Lag (ARDL) method was employed. It was observed that short-run and long-run relationships exist among the variables. Findings revealed that in the short and long run, energy consumption has positive effects on CO2 emissions in Nigeria. However, for ecological footprint, only energy consumption in the three lagged period has a positive relationship with EFP in the short run without any significant effect being observed in the long run. Similarly, an inverted U-shaped environmental degradation-economic development relationship was established in the study which validated the EKC hypothesized inverted U-shape for CO2 emissions. However, for EFP, there was no evidence of the EKC. As such, the shape of the EKC curve is subject to the environmental indicators employed. The study therefore recommends an increase in the use of alternative sources of energy that are relatively free from pollutant emissions as an alternative and viable option for Nigeria.
Türkiye’de mahalli idareler bütçe harcamalarından kimler faydalanıyor? (2006-2020)
Authors: Nacar Birsen
Published: November 2021

Bu çalışmanın amacı Türkiye’de 2006 ile 2020 yılları arası dönemde mahalli idareler bütçe harcamalarının sosyal sınıflar arasında nasıl bölüşüldüğünü araştırmaktır. Bu amaçla iki açıklayıcı kavram kullanılmaktadır. Bunlar sosyal kâr ve sosyal ücret kavramlarıdır. Sosyal kâr mahalli idareler harcamalarından sermaye kesiminin gelir veya tüketimine aktarılan kaynakları ifade eder. Sosyal ücret ise mahalli idareler harcamalarından emek kesiminin gelir veya tüketimine yapılan katkıları gösterir. Mahalli idareler bütçe harcamalarının bu iki kavramdan hareketle sınıflandırılması mahalli idarelerin sosyal kâra ve sosyal ücrete dönüşen kaynak kullanımlarını tespit etmeye olanak sağlar. Bu çalışmada ulaşılan bulgular, Türkiye’de mahalli idareler harcamalarının ortalama yüzde 70’inin sermaye kesiminin gelir veya tüketimine tahsis edildiğini göstermektedir. Mahalli idareler harcamalarından emek kesiminin gelir veya tüketimine yapılan katkı ise ortalama yüzde 30 civarında kalmaktadır. Bu sonuçlar Türkiye’de mahalli idarelerin bütçe politikalarına sermaye kesiminin çıkarlarının hakim olduğunu göstermektedir.
Dijital ekonomi çerçevesinde Türkiye’de uygulanan bütçe politikaları
Authors: Türkmen Hatice , Akar Sevda
Published: November 2021

Bu çalışmanın amacı, “Dijital Ekonomi” olarak adlandırılan yeni ekonomi anlayışının Türkiye’deki gelişimini kamu kurumlarının bütçe politikaları açısından değerlendirmektir. Türkiye’de 2017 yılında yapılan referandum ile Parlamenter Demokratik Sistemden, Cumhurbaşkanlığı Hükümet Sistemine geçilmiştir. 2018 yılı itibariyle uygulanmaya başlanan Cumhurbaşkanlığı Hükümet Sistemi ile yürütme görevi Cumhurbaşkanına verilmiştir. Bu yeni uygulama ile Türkiye'deki kamu kurumlarının teşkilat yapılarında, bütçe uygulamalarında ve BİT yatırımlarında meydana gelen değişiklikler bu çalışmanın temel konusunu oluşturmaktadır. Cumhurbaşkanlığı Hükümet Sistemi ile teşkilat yapıları değişen ya da yeni kurulan kurumların dijital politikalarını değerlendirmek için 2008-2020 bütçe ödenek cetvelleri incelenmiştir. 2008-2017 yılları arasındaki veriler Cumhurbaşkanlığı Hükümet Sistemi öncesi, 2018-2020 yılları ise Cumhurbaşkanlığı Hükümet Sistemi sonrası olarak değerlendirilmiştir. 2018 yılı bütçesi fiili uygulama öncesinde hazırlanmış olması sebebiyle Cumhurbaşkanlığı Hükümet Sistemi geçiş yılı olarak kabul edilmektedir. Söz konusu yıllar arasında kamu kurumlarının gelişim ve değişimini incelemek için bütçe ödenek cetvellerinden faydalanılmıştır. Çalışmada 2008-2017 yılları arasında kamu kurumlarında yapılan kamu bilgi iletişim teknoloji yatırımlarının sürekli arttığı görülmüştür. 2018 yılından itibaren sistem değişikliği ile birlikte kamu kurumlarının yatırımlarında yavaşlama olduğu tespit edilmiştir. Bu süreçte toplumun her kesimini ilgilendiren bilişim ve dijital dönüşümde yaşanan en önemli gelişmenin ve Cumhurbaşkanlığı Hükümet sisteminin dijital dönüşüm sürecine en önemli katkısının Dijital Dönüşüm Ofisinin kurulması olduğu ileri sürülebilir.
ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions
Authors: Martinez-Vargas Yailit del Carmen , Silva-Filho Tiago João da , Oliveira Denise Hélen Imaculada Pereira de , Gonçalo Rani Iani Costa , Queiroz Lélia Maria Guedes
Published: November 2021

Abstract The Inhibitor of Growth (ING) gene family is a group of tumor suppressor genes that play important roles in cell cycle control, senescence, DNA repair, cell proliferation, and apoptosis. However, inactivation and downregulation of these proteins have been related in some neoplasms. The present study aimed to evaluate the immunohistochemical profiles of ING3 and ING4 proteins in a series of benign epithelial odontogenic lesions. Methods: The sample comprised of 20 odontogenic keratocysts (OKC), 20 ameloblastomas (AM), and 15 adenomatoid odontogenic tumors (AOT) specimens. Nuclear and cytoplasmic immunolabeling of ING3 and ING4 were semi-quantitatively evaluated in epithelial cells of the odontogenic lesions, according to the percentage of immunolabelled cells in each case. Descriptive and statistics analysis were computed, and the p-value was set at 0.05. Results: No statistically significant differences were found in cytoplasmic and nuclear ING3 immunolabeling among the studied lesions. In contrast, AOTs presented higher cytoplasmic and nuclear ING4 labeling compared to AMs (cytoplasmic p-value = 0.01; nuclear p-value < 0.001) and OKCs (nuclear p-value = 0.007). Conclusion: ING3 and ING4 protein downregulation may play an important role in the initiation and progression of more aggressive odontogenic lesions, such as AMs and OKCs.
CHX Stabilizes the Resin/demineralized Dentin Interface
Authors: Costa Ana Rosa , Naves Lucas Zago , Garcia-Godoy Franklin , Tsuzuki Fernanda Midori , Correr Américo Bortolazzo , Correr-Sobrinho Lourenço , Puppin-Rontani Regina Maria
Published: November 2021

Abstract The aim of this study was to evaluate the effect of 2% chlorhexidine digluconate (CHX) on microtensile bond strength (µTBS) between an adhesive system and under 3 dentin conditions. For that, this study evaluated the adhesive interface at initial, after 6 months and 1 year of storage. Forty-eight human third molars were prepared and randomly divided into 3 groups, according to dentin substrates: sound dentin (Sd), caries-infected dentin (Ci) and caries-affected dentin (Ca). The groups were subdivided into two according to the dentin pre-treatment: application of 2% CHX or without pre-treatment (control). The dentin surfaces were etched with 35% phosphoric acid gel and bonded with Adper Single Bond 2 (3M ESPE) adhesive system according to manufacturer’s instructions. Subsequently, the specimens were stored in deionized water at 37°C for 24h, 6 months and 1 year. Two additional teeth were used to analyze the bonding interfaces by SEM. Data was submitted to three-way ANOVA in a split plot design and Tukey’s test (α = 0.05). The results showed that Ci decreased µTBS values when compared to Ca and Sd, regardless storages time or treatment. Stored samples for 6 months and 1 year decreased the µTBS for the control group, but no difference was found between storages time for the CHX group. As a conclusion, the 2% CHX application after etching showed improved dentin bond strength in the storage time, regardless of the substrates evaluated.
Caracterização do Fluxo de Material Após a Soldagem Dissimilar do Aço SAE 1020 à Liga de Alumínio 5052 H34 pelo Processo Hybrid Friction Stir Welding Assistido por Plasma
Authors: Cota Bruno Silva , Bracarense Alexandre Queiroz
Published: November 2021

Resumo: Esta pesquisa tratou da aplicação do processo Hybrid Friction Stir Welding na soldagem dissimilar alumínio-aço com a utilização de uma fonte de pré-aquecimento por plasma, com o objetivo de caracterizar o fluxo de material. Foram realizadas juntas soldadas a topo do aço carbono SAE 1020 e da liga de alumínio 5052 H34 com 3 mm de espessura utilizando um cabeçote desenvolvido especialmente para essa aplicação, que foi adaptado a um robô antropomórfico COMAU NJ5000 de 6 graus de liberdade e capacidade de 500 kg. O offset foi mantido em zero, ou seja, a ferramenta foi inserida na interface de soldagem. O pré-aquecimento das amostras foi realizado pela adaptação de uma máquina de corte a plasma, em que a temperatura e a corrente foram variadas em: 0 °C (sem pré-aquecimento), 250 °C (40 A), 350 °C (50 A) e 450 °C (60 A). A caracterização microestrutural foi realizada por meio de microscopia óptica e eletrônica de varredura e por difração de raios X (DRX). Durante as análises metalográficas foi identificada e caracterizada a formação de uma região altamente deformada na parte superior das amostras submetidas ao pré-aquecimento, definida neste trabalho como “cabeça”. Esta região proporciona um aumento na resistência mecânica do material, e será tão grande quanto maior for o aporte de calor no lado de avanço. O fluxo de material foi identificado e foi possível determinar quatro possíveis geometrias para a zona misturada, correlacionado com a resistência mecânica obtida e condições necessárias para se obter cada uma delas.
Evaluation of the Chemical Composition of Coatings Present on AWS A5.1 E6013 Welding Electrodes
Authors: Fernandes Bruno Luiz Mendes , Ferreira Taimara Polidoro , Sousa Rafael Arromba de , Pedreira Filho Walter dos Reis , Lowinsohn Denise
Published: November 2021

Resumo: Os eletrodos AWS A5.1 E6013 possuem elevado interesse devido a sua ampla empregabilidade. Os revestimentos destes eletrodos podem alterar os resultados da soldagem, tornando-se um interessante objeto de estudo. Uma investigação da composição química dos revestimentos dos eletrodos AWS A5.1 E6013 de quatro fabricantes brasileiros foi realizada usando espectrometria de fluorescência de raios-X por energia dispersiva (FRXED), microscopia eletrônica de varredura (MEV) e espectrometria de massa com plasma indutivamente acoplado (ICP-MS). Foram observados nas amostras compostos tais como o dióxido de titânio (TiO2), óxidos e carbonatos de metais alcalinos e alcalino-terrosos, além de Al e Si na forma de aluminosilicatos. Estes compostos auxiliam na extrusão do revestimento na etapa de fabricação do eletrodo, elevam a basicidade da escória e estabilizam o arco elétrico formado durante a soldagem. Os resultados do ICP-MS mostraram que elementos como Co, Cr, Cu e Ni são adicionados para aumentar a passividade e a resistência mecânica da junta soldada. Resíduos de Pb foram observados com teores até 700 vezes maior que o permitido pela legislação nacional. As presenças destes metais nos revestimentos evidenciam a necessidade de medidas protetivas ao manipular os eletrodos E6013.
IMPLICATIONS OF BLOCKCHAIN AND TRANSPARENCY FOR BUSINESS SUSTAINABILITY: AN INTEGRATIVE REVIEW
Authors: GIESEL HEDWIK D. , NOBRE FARLEY S. M.
Published: November 2021

ABSTRACT Purpose: Blockchain protocol comprises several attributes, among which transparency stands out. In this vein, the purpose of this article is to advance research on the implications of transparency (as derived from the use of blockchain) for business sustainability (BS). Originality/value: There is continuing interest in applying blockchain for creating and improving transparency, with this latter representing a strategic asset in BS. However, despite advancing this subject, the literature still lacks studies that explain the organizational circumstances in which blockchain can enable progress on transparency in the scope of BS. Design/method/approach: The methodology involved an integrative literature review on blockchain, transparency, and BS, and it was conducted with the support of Web of Science and Scopus to attend the research objective. Findings: The results favored the proposal of two analytical frameworks: one refers to the concepts of blockchain and transparency presented by the academic literature, and the other to the benefits of blockchain and transparency for the economic, social, and environmental BS dimensions. Furthermore, discussions involved deducing propositions about the use of blockchain to improve transparency in the BS context. The propositions open future research directions to studies that aim to test them qualitatively or quantitatively.
Entre ser português e índio “barbado”: da cidade de Nazaré (s. Luís do Maranhão, 1536) à colonização do vale do Itapecuru no século XVII
Authors: Moreira Rafael
Published: November 2021

RESUMO Este texto sintetiza os dados históricos essenciais sobre o discutido grupo dos “Barbados” do Maranhão: formação, atitudes e extinção no começo do século XVIII às mãos dos colonos e autoridades da São Luís lusa. Analisa-se o desenho do Arquivo Histórico Ultramarino (Lisboa), único testemunho que deles nos ficou - da autoria dos antagonistas -, e propõe-se uma nova abordagem a esse tipo de problemática da interação étnica.
Índios, milicianos e colonos no sul do Brasil: lideranças indígenas e o aldeamento de atalaia na ocupação dos territórios Kaingang nos campos de Guarapuava (1810-1825)
Authors: Souza Almir Antonio de , Lino Jaisson Teixeira
Published: November 2021

RESUMO O artigo propõe analisar a história da Real Expedição de Conquista dos Campos de Guarapuava, em conjunção com a presença indígena na região da Fronteira Sul de São Paulo provincial e a história do aldeamento de Atalaia e de suas lideranças indígenas. Através das fontes históricas e da bibliografia pertinente ao tema, buscamos entender as tramas interculturais estabelecidas no projeto joanino de ocupação, exploração e dominação da população nativa dos chamados campos de Guarapuava entre os anos de 1810 e 1825, território de importância para a exploração econômica e de consolidação de fronteiras com o império espanhol. Tratamos, aqui, tal processo de povoamento como uma invasão aos territórios tradicionais ocupados desde a pré-história pelos povos de língua Jê, em especial as diferentes parcelas Kaingang que, em face da nova configuração histórica que se apresentava, procuraram, por estratégias de ações políticas ou de conflito evidenciadas no protagonismo das lideranças indígenas, defender-se dos interesses de milicianos e colonos, e que permitiram um espaço territorial de sobrevivência dessas populações.
UM RELATO DA EDUCAÇÃO DE ESTUDANTES SURDOS NO MUNICÍPIO DE CHAPECÓ (SC)
Authors: Pieczkowski Tania Mara Zancanaro
Published: November 2021

RESUMO Este artigo objetiva evidenciar a educação de surdos no município de Chapecó (SC), explicitando os fundamentos teóricos estruturantes e os processos de formação docente para esta especificidade no período de 1996 a 2016. A pergunta que orientou a investigação assim se constitui: Como a educação de surdos foi desenvolvida de 1996 a 2016 na rede municipal de educação de Chapecó e quais os fundamentos teóricos estruturantes nos processos de formação docente? A pesquisa se caracteriza como qualitativa numa perspectiva pós-estruturalista. Participaram do estudo três secretários municipais de educação que exerceram a função por maior tempo em cada gestão municipal do período pesquisado. Além de pesquisa documental, foram realizadas entrevistas semiestruturadas, gravadas, transcritas e organizadas em agrupamentos temáticos. As materialidades empíricas foram examinadas por meio da análise do discurso com referenciais foucaultianos. O estudo evidencia que em cada tempo são instituídas verdades acerca da educação de surdos e que abordagens teórico-metodológicas, adotadas em contextos históricos e geográficos mais amplos, se manifestam também na região investigada.
Parametric analysis related to dimensioning of tubular steel columns filled with concrete in a fire situation
Authors: Rodrigues Fábio Masini , Moreno Júnior Armando Lopes , Munaiar Neto Jorge
Published: November 2021

ABSTRACT For the dimensioning of structural elements in fire situation, simplified equations and parameters are commonly used in analytical equations or numerical models. More complex equations or simplified values can be chosen by the designer for determine materials properties in high temperature in numerical models, however, numerical modeling can be quite sensitive to the variation of some of the physical and mechanical properties. In this paper, the sensitivity of the numerical model in relation to the values according to the level of simplification chosen was evaluated, presenting an analysis in relation to the results found to contribute to the choice of these parameters and presenting the indications found in the literature. In this sense, this work presents a study of sensitivity to the variation of the values of steel and concrete properties, presented in the Eurocode and Brazilian standards, in addition to the moisture content and emissivity of the surface exposed to fire, for the dimensioning, in a fire situation, of steel tube columns, of circular and square section, filled with concrete. The studies were carried out via numerical modeling developed in the software ABAQUS. It was verified that the resulting emissivity values equal to 0.7 or 0.8, recommended in the literature, are conservative, and the choice of either does not bring significant changes in the temperature field obtained for the structural elements under analysis. It was also verified that the concrete moisture content is a relevant aspect for the formation of its temperature field, also affecting, but to a lesser extent, the steel temperature. Regarding the physical and mechanical properties of the materials, this sensitivity study suggests the adoption of the values from the equations presented in Eurocodes, without simplifications, and with the specific heat and thermal conductivity of the concrete, adopted in accordance with the Eurocode 4.
Performance of variously shaped glass-fibre-reinforced polymer bars in concrete columns
Authors: Ahmad Afaq , Elchalakani Mohamed , Iqbal Muhammad , Huang Yimou , Ma Guowei
Published: November 2021

An investigation was carried out into the structural performance of concrete columns reinforced with various shapes of glass-fibre-reinforced polymer bars and stainless steel stirrups under concentric loading at ultimate limit state. Six square-section columns were cast to investigate the effects of different reinforcement types. The results showed failure modes depended on reinforcement material, shape and stirrup spacing. Across all specimens, steel-reinforced columns had higher loading capacity and better ductile performance, followed by L-shape and then round polymer bars. Smaller spiral spacing increased confinement efficiency and ductility and provided sufficient restraint against longitudinal polymer bar buckling. Finite-element models were also calibrated, and the results were in close agreement with experimental measurements. Based on the calibrated models, numerical parameters were studied to understand further the behaviour of composite columns reinforced with glass-fibre-reinforced polymer.
Investigation of Dry Granulation and Wet Granulation Effect on Dissolution Profile of the Developed Film Coated Tablets Containing Eplerenone
Authors: Eİ Deniz , C Toprak , G Gun
Published: November 2021

The objective is to observe and improve drug release of Eplerenone which is BCS Class II API by applying dry granulation and wet granulation process. Inspra 50 mg film coated tablets, manufactured by Pfizer, were taken as reference product to compare with dissolution profiles of dry granulation applied product and wet granulation applied product. Investigation of the effect of wet granulation process on dissolution profiles of Eplerenone 50 mg film coated tablets has been demonstrated out in the scope the study. While f2 similarity factor is 44.93 for dry granulation applied product, it is 60.62 for wet granulation applied product when compared to reference product. It comply that dissolution rate of wet granulation applied product is more proper to the specification than dry granulation applied product. The study demonstrates the effect of different granulation process on dissolution rate.
Genetic Effects of Ultra-High-Diluted-Biomedicines Gall 30C, Gall 200C, and Gall 1000C may be Vaccines against Plant and COVID-19 Diseases: Improved Agriculture-Health-Medical-Pharmaceutical-ScienceTechnology-Communication-Issues!
Authors: SC Datta
Published: November 2021

The current coronavirus 2 (SARS-CoV-2) outbreaks of Coronavirus disease 2019 (COVID-19) pandemic have emphasized the vulnerability of human populations to novel viral pressures, causing an emergent global pandemic and badly impacts on agriculture-environment-health-socio-economy medical-pharmaceutical-science-technology-communication-issues. And India emphasis on okra, Abelmoschus esculentus (L.) Moench Cv. Ankur-40, the ‘Nature’s-Gift to Human-Disease-Free-Healthy-Life’ and the most ‘Economically-Important Number-One Consumption-Vegetable-Crops,’ is damaged by different pathogens like nematodes, causing the root-knot (RK) disease which is easily controlled by different chemical-pesticides, and so it is an urgent need to develop potential epidemiological and biomedical vaccines. The Ultra-High-Diluted Biomedicines (UHDBM) Gall 30C, Gall 200C, and Gall 100C, prepared from Okra Root-Galls (ORG) or Gall MT, applied by foliar spray @ 20 mL/plant each group respectively, are highly effective against the root-knot disease of okra, with increasing fresh-plant growth and fruit production. The UHDBM; Gall 30C, Gall 200C, and Gall 1000-pretreatments are more effective than the untreated ones, and Gall 200C shows the most potential result in all respects. The genetic-effects of UHDBM thought to induce systemic acquired resistance response of the treated plants through the expression of pathogenesis-related (PR)- proteins-genes (22 to 4 numbers), which are more or less similar molecular range (295 kD to 11 kD) of many coronaviruses, and it will responsible for preventing RK and COVID-19 like variant-virus diseases by inducing defense-resistance or increasing innate-immunity, and enriching agricultureenvironment-health-socio-economy-medical-pharmaceutical-science-technology-communication-issues (AEHSEMPSTCI) with the toxic-free world, and it may help to develop best potential new preventive treatments methods or drug or vaccines, in the field of ‘21st Century COVID-19 like Pandemic in the new normal situation in future.
Intervenção pedagógica para o desenvolvimento de habilidades de tradutores em formação sobre questões de textualidade via abordagem Ler para Aprender
Authors: Vieira Teresinha Penaforte , Praxedes Filho Pedro Henrique Lima
Published: November 2021

Este artigo relata um estudo de intervenção pedagógica desenvolvido com tradutores em formação na Universidade Estadual do Ceará, no qual foi adotada a abordagem pedagógica sistêmico-funcionalista da Escola de Sydney (ROSE; MARTIN, 2012; entre outros) com algumas adaptações para a atividade tradutória. O estudo teve como foco o desenvolvimento da subcompetência bilíngue e metarreflexão dos participantes (HURTADO ALBIR, 2005; PACTE, 2003) quanto aos aspectos relativos à tessitura textual (HALLIDAY; MATHIESSEN, 2014; MARTIN, 1992; entre outros). O corpus, constituído por respostas a questões de atividades pedagógicas e comentários feitos em entrevistas, foi analisado qualitativamente, abordando-se o produto e processo tradutórios. Os resultados apontaram uma significativa elevação no nível de subcompetência bilíngue dos participantes e também no nível de sua capacidade metarreflexiva sobre os aspectos abordados, elevando suas habilidades de leitura, de produção e revisão textual e, por conseguinte, suas habilidades tradutórias.
Correlación del Finnish Diabetes Risk Score y la Hemoglobina Glucosilada en la Identificación de Diabetes y Prediabetes en Docentes Universitarios de Ciencias de la Salud.
Authors: Torres Hernadez Rosa María , López Balderas Nayali , González Jiménez Beatriz , Rosas Murga Flor Patricia , López Ramos Emma Delfina
Published: November 2021

Introducción:   La Diabetes Mellitus se caracteriza por elevación de glucosa en sangre. En el año 2014 vivían 422 millones de personas con diabetes (8.5%) a nivel mundial. En México, en el 2018 vivían aproximadamente 8.6 millones de personas con diabetes (10.3%) y el 70% de la población adulta presentaba sobrepeso u obesidad. Se ha buscado validar herramientas de bajo costo para ampliar la atención médica de población en riesgo de padecer diabetes. El test de FINDRISC es un instrumento utilizado a nivel mundial para evaluar el riesgo de desarrollar diabetes tipo 2. El objetivo de este estudio fue analizar la correlación entre el puntaje del FINDRISC y el valor de la hemoglobina glucosilada en docentes del área de ciencias de la salud en la Universidad Veracruzana. Métodos: Estudio observacional y transversal. Se aplicó el cuestionario FINDRISC a 92 docentes procedentes de Facultades de Ciencias de la Salud, en los que además se determinó la hemoglobina glucosilada. Resultados: El porcentaje de docentes en riesgo alto fue de 26.1% y de 7.6% en riesgo muy alto. Se identificó un 10% de docentes con prediabetes y 7.1% con diabetes no diagnosticada. Solo 24 docentes (26.1%) presentaron peso normal, 40 con sobrepeso (43.5%) y 28 con obesidad (30.4%). La correlación de Pearson del test FINDRISC con la hemoglobina glucosilada fue de r = 0.50 (I.C. 95% 0.35-0.64). Conclusión: El test FINDRISC junto con la hemoglobina glucosilada son útiles para identificar grupos de riesgo para desarrollar diabetes tipo 2 en población veracruzana.