bluuebunny/crossref_metadata_2025 huggingface dataset:
KONDISI DAN STRATEGI PERTAHANAN MARITIM INDONESIA DI KAWASAN ASIA TENGGARA
Authors: Yulyanti Rizky Thesalonika
Published: September 2023

Kawasan Asia Tenggara merupakan kawasan yang secara geografi sangat strategis dan dapat dipengaruhi langsung oleh kekuatan politik dunia yang lebih besar. Potensi kekayaan alam yang terdapat Asia Tenggara tentunya menjadi target tersendiri bagi pemangku kepentingan untuk memperbesar pengaruhnya. Pengaruh negara besar di Asia seperti Cina ternyata memiliki pengaruh yang luar biasa dalam proses pengambilan keputusan negara ASEAN dalam menjalankan strategi maritimnya. Dari sudut pandang negara ASEAN sendiri perlu adanya tindakan kerjasama antar negara di wilayah regional dengan tujuan untuk mempertahankan pengaruh dan independensi keputusan. Atas dasar inilah dibentuknya ASEAN Maritime Forum (AMF) sebagai wadah negara-negara ASEAN dalam mengambil keputusan dan menentukan strategi dalam bidang maritim
STRATEGI MEMBANGUN PERTAHANAN MODERN KEKUATAN LAUT INDONESIA DALAM MENGHADAPI ANCAMAN GLOBAL
Authors: Imannurdin Yusup
Published: September 2023

Indonesia merupakan negara dengan wilayah lautan yang lebih luas daripada wilayah daratan. Sehingga menimbulkan kerawanan terhadap berbagai kemungkinan ancaman maritim. Maka dari itu sudah selayaknya pemerintah Indonesia menjadikan keamanan maritim sebagai prioritas dalam kebijakan pertahanan yang dikeluarkan. Mengingat didalam membangun sebuah sistem pertahanan yang kuat, paling tidak membutuhkan pertimbangan pada empat hal berikut: faktor geografis negara yang bersangkutan, sumber daya nasional sebuah negara, analisis terhadap kemungkinan ancaman yang akan muncul, dan perkembangan teknologi informasi. Ancaman pertahanan modern yang muncul dewasa ini membuat spektrum pertahanan sebuah negara tidak bisa lagi parsial, apalagi ancaman yang muncul dari sektor kelautan pun semakin beragam. Strategi pertahanan laut merupakan bagian dari strategi pertahanan nasional, dimana permasalahan mengenai potensi konflik, energi, ekonomi merupakan hal yang mutlak dan harus dipertahankan, dan sebagai negara yang sebagian besar wilayahnya terdiri dari laut, sudah sepatutnya sektor kemaritiman memperoleh perhatian lebih dari para pembuat kebijakan. Tulisan ini akan menganalisa strategi pertahanan laut Indonesia dalam menjaga keamanan maritim dengan menggunakan teori strategi pertahanan lau. Metode penelitian yang digunakan dalam tulisan ini adalah deskriptif kualitatif studi pustaka. Hasil penelitian menujukan bahwa pentingnya wilayah perairan Indonesia dan prospek ancamannya, Kesimpulan penelitian ini bahwa Indonesia dapat memperkuat kapabilitas kekuatan pertahanan maritimnya dengan memperkuat komando laut, menguasai dan mengontrol jalur komunikasi maritim serta melakukan pengamatan akan kapabilitas militer pihak-pihak yang terlibat serta penerapan strategi perang semesta yang melibatkan seluruh komponen sumber daya yang dimiliki dengan melibatkan instansi lain yang terkait merupakan salah satu langkah yang dapat diambil oleh pemerintah.
Enfermedades transmitidas por bacterias patógenas presentes en los alimentos en América del Sur, artículo de revisión
Authors: Delgado Chiriboga Jeanina Mikaela , Monge Jachero Joseline Viviana , Verdugo García Ligia
Published: September 2023

Resumen Introducción. Las Enfermedades transmitidas por bacterias patógenas constituyen un tema de salud pública a nivel mundial, estas afectan especialmente a los países de ingresos bajos y medios, por ejemplo, los países de América del Sur. Objetivo. Describir las principales enfermedades transmitidas por bacterias patógenas presentes en los alimentos en América del Sur. Metodología.  Este artículo es de revisión bibliográfica; para la selección de los artículos científicos se utilizó las bases de datos electrónicas desde el año 2016 debido a la falta de artículos científicos recientes. Además, se utilizó el Método PRISMA para la clasificación de la información donde se incluyeron 43 estudios. Resultados. Las enfermedades trasmitidas por bacterias de mayor predominancia fue la salmonelosis (17/38; 44,7%). Los agentes etiológicos frecuentes fueron la Salmonella spp. en un 46,5% y E. coli en un 25,6%. En Ecuador, Colombia, Perú y Chile, la enfermedad transmitida por bacterias que tuvo mayor predominio fue la salmonelosis en un 41,7%, 24,5%, 30% y 50%, respectivamente; en Paraguay y Brasil, el síndrome diarreico y en Argentina la colitis hemorrágica, síndrome urémico hemolítico y púrpura trombocitopénica trombótica. Conclusión.  La enfermedad transmitida por bacterias de mayor predominancia en América del Sur es la salmonelosis, los agentes etiológicos más frecuentes asociados a brotes fueron Salmonella spp. y E. coli. La salmonelosis predomina en Ecuador, Colombia, Perú y Chile, mientras que en Paraguay y Brasil fue el síndrome diarreico y en Argentina la colitis hemorrágica, síndrome urémico hemolítico y púrpura trombocitopénica trombótica. Área de estudio general: medicina. Área de estudio específica: tropicales y desatendidas. Tipo de estudio: revisión bibliográfica.
Introducción a los tratamientos térmicos: conceptos, propósitos y aplicaciones industriales.
Authors: Berrezueta Espín Tania Karina , Arregui Paredes Axel Vladimir , Santillán Salazar Adrián Josué , Yucta Vargas Anthony David
Published: September 2023

La presente investigación tiene como finalidad analizar distintas investigaciones que tratan sobre los tratamientos térmicos en la Ciencia e Ingeniería de los Materiales, y muestra el impacto que los mismos generan en la mejora de propiedades de diversos materiales usados en distintas industrias, según sea su aplicación o necesidad. Mediante el estado del arte se pudo establecer la importancia y aplicaciones de los tratamientos térmicos, los cuales son procesos importantes que permiten controlar la estructura de los materiales y mejorar sus propiedades físicas y mecánicas, dichos tratamientos juegan un papel crucial para el desarrollo y mejora de materiales utilizados en diversas industrias. Como resultado de la investigación se determina de forma clara las bases teóricas de los tratamientos térmicos, explicando los distintos tipos de tratamientos térmicos y los fenómenos de difusión y transformación de fases de cada proceso. Finalmente se pudo establecer los verdaderos propósitos de los tratamientos térmicos, destacando la importancia en la optimización de propiedades mecánicas como resistencia, dureza, tenacidad y ductilidad, además, se utilizan casos de estudio para ejemplificar como han mejorado las propiedades de los metales y por último mencionar técnicas avanzadas como el endurecimiento y el refinamiento para obtener estructuras como propiedades plásticas, elásticas, de tracción y de compresión.
La actividad física en el desarrollo de la autoestima de los estudiantes universitarios UTA.
Authors: Salinas Morales Anabel Carolina , Paredes Bermeo Paulina Rosalba , Sailema Torres Ángel Aníbal , Morales Jaramillo María Belén
Published: September 2023

El presente artículo tiene como propósito el desarrollo de una investigación que proporcione información sobre la relación entre actividad física y autoestima de los estudiantes de la Carrera de Pedagogía de la Actividad Física y Deporte, de la Universidad Técnica de Ambato cabe mencionar que la realización de la investigación fue sustentada bajo la necesidad de comprobar la relación existente entre las variables propuestas en el contexto del Covid-19 durante el inicio de la pandemia en la población estudiantil de la carrera de Actividad física y Deporte de la Universidad Técnica de Ambato, población que se encontraba en el proceso académico-práctico, ejerciendo actividad física en confinamiento de acuerdo al pensum universitario, de acuerdo con la primera variable fue importante recopilar información acerca de los niveles de autoestima del mismo modo establecer la relación con la práctica deportiva en respuesta a determinar cómo estos niveles aumentan o disminuyen en relación de dependencia de las variables en las siguientes fases: Objetivos: La presente investigación tuvo como objetivo principal determinar la relación existente entre actividad física y autoestima de los estudiantes de la carrera de Pedagogía de la Actividad Física y Deporte, de la Universidad Técnica de Ambato. Metodología: se empleó una metodología de orden cuantitativo, bajo un diseño de trabajo no experimental, de corte descriptivo-transversal, y una modalidad de investigación bibliográfica – documental. Los instrumentos empleados para levantar la información fueron: el Cuestionario Internacional de actividad física (IPAQ), avalado por la OMS el cual consta de siete ítems, y el Cuestionario de medición de Autoestima conformado por 40 ítems, donde dichas preguntas estuvieron direccionadas a recabar datos referentes a la actividad física y la autoestima de los evaluados. La selección de los participantes se la efectuó por medio de un muestreo probabilístico por voluntariado (322 estudiantes), quienes llenaron la encuesta en línea mientras estuvo activa. Resultados: Los resultados evidencian que, no existen estudiantes con un nivel de autoestima baja, sin embargo, los niveles medio, bueno y alto son predominantes sobre el anterior, y de igual forma, las actividades físicas predominantes se apegan a la actividad física baja y permanecer sentado sobre las actividades físicas de mayor intensidad. Conclusiones: se comprobó la hipótesis de trabajo planteada: La actividad física si incide en la autoestima de los estudiantes de la carrera de Pedagogía de la Actividad Física y Deporte. Área de estudio general: Salud. Área de estudio específica: Actividad Física – Bienestar Psicológico.
PELATIHAN DAN PENDAMPINGAN DALAM PEMBUATAN LAPORAN KEUANGAN USAHA KECIL MENENGAH AJIE FS
Authors: Verandita Clara
Published: September 2023

Abstract             Micro, Small and Medium Enterprises (MSMEs) are economic business activities carried out by individuals, households or business entities in accordance with applicable regulations. This study aims to discuss financial issues, especially regarding the preparation of financial reports based on SAK EMKM (Financial Accounting Standards for Micro, Small and Medium Entities) for individual companies or Micro, Small and Medium Enterprises (MSMEs). This Independent Study Report is written based on experience, research, and field conditions obtained during the Independent Study activity carried out at the Ajie FS Store Bandar Lampung for two months starting from February 11, 2021 to April 12, 2021. The problems faced by MSMEs are: there are some MSMEs who are not familiar with how to prepare financial reports in accordance with applicable regulations. Thus the author will help SMEs in solving the problem by helping the preparation of financial statements. Keywords: UMKM, Financial Reports, SAK EMKM.
PENGADAAN TEMPAT SAMPAH UNTUK MENINGKATKAN KEBERSIHAN LINGKUNGAN DESA PULAU PAYUNG RUMBIO JAYA
Authors: Mursyid Harsanto , Zahirni Sarah , Ginting Gracia Welly , ' Fahriadi , Hersya Vivi , Amalia Fitri , Zahran Dzaky , Anggita Tri Dwi , Rama Biefanza , Harta Nadia
Published: September 2023

The problem that is being faced by the world at this time is the waste problem, even in Indonesia itself it has not been resolved. Especially in Pulau Payung Village, which needs special attention regarding waste due to the crisis in the existence of trash bins, therefore the procurement of trash bins is carried out. The purpose of this activity is to increase public awareness about disposing of waste in its place so that the environment becomes cleaner and healthier. This activity consists of four stages, namely the preparation, implementation, final and evaluation stages. The evaluation was carried out by interviewing several resource persons involved in village management. The results of the service are considered quite good because they can encourage public awareness about cleanliness so that the environment becomes cleaner and healthier.
PEMBUATAN ARANG BRIKET SEBAGAI BAHAN BAKAR ALTERNATIF DALAM INDUSTRI PANDAI BESI
Authors: Hampratama Ahlunazaril
Published: September 2023

Penelitian ini dilakukan untuk memanfaatkan limbah tempurung kelapa yang ada dimasyarakat dengan mengolahnya menjadi briket. Tujuan penelitian untuk mengetahui kualitas briket arang tempurung kelapa yang baik untuk digunakan sebagai bahan bakar alternatif. Pembatasan masalah dalam penelitian ini yaitu tepung kanji dan tepung sagu dengan perbandingan komposisi 90:10. Tekanan pengepresan yang digunakan yaitu 2000kg/cm2. Suhu pengeringan yaitu100°C menggunakan panas matahari selama 3 hari. Suhu karbonisasi adalah 500°C. Tempurung kelapa yaitu 1 kg, perbandingan perekat adalah 100 gram/0,2 liter air dan tidak menggunakan pelapis. Metode yang digunakan dalam penelitian ini adalah metode pirolisis dengan proses pembakaran menggunakan tungku pembakaran tertutup dan pengayakan menggunakan ayakan dengan ukuran 40-60 mesh. Selanjutnya pengujian kualitas briket yaitu kadar air briket (%), kadar abu briket (%), kadar zat menguap (volatile matters) (%), kadar karbon terikat (fixed carbon) (%), pengukuran kerapatan (density) (g/cm2), berat jenis (kg/m3), pengukuran laju pembakaran (gr/menit) dan keteguhan tekan (kg/cm2). Hasil pengujian kualitas briket arang tempurung kelapa didapatkan nilai rata-rata kadar air adalah 3,42 %, nilai rata-rata kadar abu adalah 3,318 %, nilai rata-rata kadar zat menguap adalah3,31%, nilai rata-rata kadar karbon terikat adalah 93,37%, nilai rata-rata kerapatan adalah 1,55g/cm3,nilai rata-rata berat jenis adalah 1,52×10-6 kg/m2.s2, nilai rata-rata laju pembakaran adalah 0,342g/cm2, nilai rata-rata keteguhan tekan adalah 761,5N/m2.Kata kunci: Arang briket, alternatif, pandai besi
DIVERSIFIKASI PRODUK BAHAN BAKU LOKAL PADA KELOMPOK USAHA BERSAMA (KUB) DI DESA PULAU GADANG KABUPATEN KAMPAR
Authors: Zamaya Yelly , Misdawita Misdawita , Taryono Taryono , Arifudin Arifudin
Published: September 2023

Desa Pulau Gadang Kecamatan XIII Koto Kampar Kabupaten Kampar memiliki Kelompok Usaha Bersama (KUB) yang bernama Tabayang Kreatif, dimana merupakan salah satu usaha kelompok usaha kerajinan yang memproduksi dan memasarkan berbagai produk kerajinan dan souvenir dengan memanfaatkan bahan lokal yaitu tempurung kelapa. Berkembangnya destinasi wisata di Kabupaten Kampar menjadi pasar bagi produk-produk berbahan baku lokal. Tingkat permintaan terhadap produk hasil kerajinan dan souvenir dari tempurung kelapa saat ini cukup tinggi, namun KUB Tabayang Kreatif memiliki keterbatasan keahlian sumber daya manusia untuk mengembangkan variasi dan desain dari produk yang dihasilkan. Kegiatan pengabdian ini dilakukan dengan cara memberikan pelatihan diversifikasi produk berbahan baku lokal yang dihasilkan oleh anggota KUB Tabayang Kreatif dengan tujuan untuk meningkatkan pendapatan. Setelah dilakukannya pelatihan diversifikasi produk, KUB Tabayang Kreatif sudah mampu memproduksi berbagai produk kerajinan dari tempurung kelapa dan bambu. Dengan semakin berkembangnya produk yang dihasilkan maka diharapkan akan meningkatnya pendapatan para anggota dan bertambahnya minat penduduk sekitar memanfaatkan bahan baku lokal yang ada untuk menambah penghasilan rumah tangga.
SOSIALISASI DAN PELATIHAN PEMBUATAN SABUN CUCI PIRING EKONOMIS PADA KELOMPOK MASYARAKAT DI KELURAHAN RINTIS, KOTA PEKANBARU
Authors: Sidabalok Supriani , Zamaya Yelly , Yovita Indri
Published: September 2023

Penggunaan sabun cuci piring tidak dapat dipisahkan dari kehidupan masyarakat. Mengingat fungsi produk ini sangat penting untuk menjamin kebersihan alat-alat rumah tangga. Pengeluaran untuk membeli produk ini sifatnya permanen dan berulang setiap waktu. Berdasarkan pengamatan yang dilakukan oleh tim pengabdian diketahui bahwa biaya yang dikeluarkan untuk membeli bahan komposisi pembuatan sabun cuci piring lebih ekonomis dibandingkan dengan harga sabun cuci piring siap pakai. Dengan demikian, jika masyarakat mampu memproduksi sabun cuci piring sendiri maka hal tersebut akan memberikan keuntungan dari selisih biaya tersebut. Keuntungan yang diperoleh dapat berupa penghematan pengeluaran rutin rumahtangga dan hal ini berpotesi menjadi peluang usaha yang akan menambah pendapatan bagi masyarakat. Masyarakat merasa lebih aman dan tidak khawatir dalam menggunakan produk karena mengetahui dengan baik bahan-bahan yang digunakan. Berdasarkan analisis situasi dan latar belakang tersebut, maka tim pengabdian dan Kukerta UNRI melaksanakan kegiatan sosialisasi pembuatan sabun cuci piring di Kelurahan Rintis dengan harapan masyarakat akan mendapatkan pengetahuan pembuatan sabun cuci piring sendiri.
PENYULUHAN KESANTUNAN BERBAHASA DI SMA AGAPE HALMAHERA BARAT
Authors: Duwila Ety , Rauf Ramis , Ulya Afriani
Published: September 2023

The era of digitalization opens spaces for anyone to express themselves, primarily through virtual spaces such as Facebook, YouTube, Instagram, TikTok, and Twitter. The implication is that cultural and moral degradation is caused by foreign cultural intervention through content uploaded on social media, especially regarding impoliteness in language. Social media has several forms of language impoliteness, such as swearing, threats, insults, and hoax news. This form of language impoliteness in social media leads to defamation and hate speech. Defamation and hate speech violate Law Number 19 of 2016 concerning Information and Electronic Transactions (ITE). The problem of defamation and hate speech is one of the vital national issues that must be resolved. Therefore, as a lecturer responsible for the tri dharma of higher education, the authors plan to conduct community service titled "The Counseling of Language Politeness at SMA Agape West Halmahera".
Risk Factors for Prevertebral Soft Tissue Swelling Following Single-level Anterior Cervical Spine Surgery
Authors: Park Junsang , Kang Sang Mook , Won Yu Deok , Han Myung-Hoon , Cheong Jin Hwan , Ha Byeong-Jin , Ryu Je Il
Published: September 2023

Objective : Anterior cervical spine surgery (ACSS) is a common surgical procedure used to treat cervical spinal degenerative diseases. One of the complications associated with ACSS is prevertebral soft tissue swelling (PSTS), which can result in airway obstruction, dysphagia, and other adverse outcomes. This study aims to investigate the correlation between various cervical sagittal parameters and PSTS following single-level ACSS, as well as to identify independent risk factors for PSTS.Methods : A retrospective study conducted at a single institution. The study population included all patients who underwent single-level ACSS between January 2014 and December 2022. Patients with a history of cervical spine surgery or trauma were excluded from the study. The presence and severity of PSTS was assessed by reviewing pre- and postoperative imaging studies. The potential risk factors for PSTS that were examined include patient age, sex, body mass index, tobacco use, comorbidities, serum albumin levels, operative time, implant type, implanted level, and various cervical spine sagittal parameters. Multivariate linear regression analysis was performed to identify the independent risk factors for PSTS.Results : A total of 62 consecutive patients who underwent single-level ACSS over a 8-year period at a single institution were enrolled in this study. Only preoperative segmental angle showed positive correlation with PSTS among various cervical spine sagittal parameters (r=0.36, p=0.005). Artificial disc replacement showed a negative correlation with PSTS (β=-0.38, p=0.002), whereas the use of demineralized bone matrix (DBM) had a positive impact on PSTS (β=0.33, p=0.009). We found that male sex, lower preoperative serum albumin, and implantation of upper cervical level (above C5) were independent predictors for PSTS after single-level ACSS (β=1.21; 95% confidence interval [CI], 0.27 to 2.15; p=0.012; β=-1.63; 95% CI, -2.91 to -0.34; p=0.014; β=1.44; 95% CI, 0.38 to 2.49; p=0.008, respectively).Conclusion : Our study identified male sex, lower preoperative serum albumin levels, and upper cervical level involvement as independent risk factors for PSTS after single-level ACSS. These findings can help clinicians monitor high-risk patients and take preventive measures to reduce complications. Further research with larger sample sizes and prospective designs is needed to validate these findings.
MYANMAR MILITARY COUP ON 2021 : RESTORE THE GLORY ERA OF OPIUM
Authors: Mandagie Mike Natanael Norend
Published: September 2023

Military coups are nothing new in the 21st century. Myanmar's military overthrew the existing democratic government in a coup d'état to gain power. Opium is the key behind the Myanmar military coup taking place in 2021. This article was written using both qualitative and quantitative methodologies. News in the mass media, both print and online, is also a source. The thirst for power has influenced the existing military so that actions without morals are committed. Many people consider that the coup carried out by the Myanmar military was an ordinary coup that was normalized because of the thirst for power. But behind that thirst for power lies a bigger plan for profit. The public needs to see the real reason behind the coup carried out by the Myanmar military in 2021 so that it can clearly and structuredly understand the coup that was carried out in 2021 which further put Aung San Suu Kyi under house arrest

Keywords: Opium, Government, Military, Power, Coup
ANALISIS PENGARUH TEMPERATUR AUSTENITE DAN MEDIA QUENCHING MATERIAL S45C DAN EMS45 TERHADAP KEKERASAN
Authors: Nugraha Aditya , Arifin Kurniawan Sindu , Setiawan Daniel Calvin
Published: September 2023

Hardening adalah perlakuan panas dengan tujuan meningkatkan kekerasan pada baja. S45C merupakan material yang banyak digunakan sebagai part mesin yang membutuhkan proses harden. Pada beberapa kasus, material S45C tidak bisa menghasilkan kekerasan 50 HRC sesuai dengan katalog, maka diperlukan material pembanding sebagai material yang setara. Penelitian ini akan membandingkan material S45C dengan material EMS45 dilihat dari kekerasan yang dihasilkan sebagai opsi pengganti material S45C. Variasi temperatur austenite yang digunakan  adalah 800° C , 825° C , 850° C , dan media quenching yang digunakan adalah oli, air-oli, dan air. Metode ANOVA digunakan untuk mengetahui pengaruh variasi temperatur dan media quenching. Material S45C, kekerasan 50 HRC didapatkan pada temperatur austenite 800° C, 825° C, dan 850° C dengan media quenching air. Pada material EMS45, kekerasan 50 HRC didapatkan dengan media quenching air, air-oli, dan oli pada temperatur austenite 850° C,  dan 800° C dengan media quenching air-oli. Untuk material S45C, media quenching memiliki pengaruh 81%, dan temperatur austenite 4,2% terhadap hasil uji kekerasan sedangkan, material EMS45 media quenching memiliki pengaruh 83,9% dan temperature austenite 5,9% terhadap hasil uji kekerasan. Material EMS45 bisa digunakan sebagai material pengganti S45C.

Kata Kunci: harden, temperatur austenite, dan media quenching
PENGARUH SUDUT POTONG TERHADAP GETARAN PAHAT DAN KEKASARAN PERMUKAAN PADA PROSES BUBUT MILD STEEL BAJA ST37
Authors: Sadiana Riri , Ekawati Fatimah Dian , Surahto Aep , Fadilah Rizki Yasin
Published: September 2023

Abstrak

Menentukan sudut potong pada proses bubut untuck menghasilkan kekasaran permukaan dan getaran pahat yang optimal pada proses bubut mild steel Baja ST 37. Tujuan penelitian ini adalah untuk mengetahui pengaturan sudut potong yang tepat pada proses bubut, sehingga dapat meminimumkan kekasaran permukaan dan getaran pada pahat dalam proses bubut mild steel Baja ST 37. Melalui metode eksperimen dengan sampel sebanyak 9 spesimen, dengan parameter kecepatan gerak makan 0.2 mm/rev, kedalaman pemotongan 1 mm, putaran mesin 800 rpm, dan variasi sudut potong 650, 750, dan 850 diperoleh hasil bahwa pengaturan sudut potong yang dipilih, meskipun semakin besar nilai sudut potong yang dipilih (untuk rentang 650 -850) maka akan semakin kecil nilai permukaan kekasaran yang diperoleh dari suatu proses bubut baja ST37 dengan parameter yang telah ditetapkan, pemilihan sudut potong 750 akan menghasilkan nilai rata-rata getaran terkecil, nilai kecepatan getaran yang diperoleh juga cenderung stabil.

Kata Kunci: Sudut Potong, Baja ST 37, Getaran

 

Abstract

The motivation for this study was to determine the importance of the cutting angle during turning for optimal surface roughness and tool vibration during turning of mild steel ST-37. ST-37 Tool Vibration During Light Turning. Through the experimental program of 9 samples, the feed rate is 0.2mm/rev, the cutting depth is 1mm, the motor speed is 800rpm, and the cutting angle is changed to 650, 750 and 850. The result is that the selected cutting angle setting, although the selected cutting the larger the angle value (range 650-850), the smaller the surface roughness value obtained by the ST37 steel turning process with predefined parameters, the choice of angle cutting 750 is the average value of the smallest vibration, and the obtained value of vibration speed n also tends to be stable.

Keywords: Angle of Cut, Steel ST 37, Vibration
MARKETING COMMUNICATION STRATEGIES FOR INCREASING THE SALES OF DIGITAL PRINTING PRODUCTS
Authors: Hamluddin Hamluddin , Wibowo Marcellino Daffa Arya
Published: September 2023

The printing industry, especially digital printing, has experienced rapid advancement amidst fierce competition and increasing technological progress. Marketing communication strategies have become crucial in achieving product marketing goals. This study focuses on understanding marketing communication strategies in the printing industry, specifically digital printing. Utilizing the 7P marketing mix theory, the study employs a qualitative descriptive method with data collection through observation, interviews, and documentation. The post- positivism paradigm is adopted with triangulation technique for data validity. The aim is to uncover company marketing strategies, enhance sales, and identify supporting and hindering factors in marketing. The results of the current study show that the implementation of marketing strategies seem to yield positive effects. The latter points are caused by factors such as product quality, affordable price and excellent after-sales quality. The implications of the results are also discussed.
Influencia del reforzamiento mediante tejidos de polímeros reforzados con fibras en el desempeño ante carga de sismo de una edificación de hormigón armado.
Authors: Zamora Díaz-Comas Omar
Published: September 2023

En el presente artículo se analiza la influencia del reforzamiento mediante tejidos de polímeros reforzados con fibra de vidrio (PRFV) en el desempeño ante carga de sismo de una edificación de pórticos de hormigón armado, a partir de la implementación del método estático no lineal. Se emplea el programa computacional ETABS V18.1. Se analizan dos tipos de modelos de la edificación objeto de estudio: el modelo de la estructura sin ningún reforzamiento y el modelo de la estructura reforzada mediante tejidos de PRFV. Se reportan y establecen diferencias, para los dos modelos realizados, de los valores de desplazamientos en el tope de la edificación, cortante basal, cortante y desplazamiento de fluencia, punto y nivel de desempeño y valores de cortante basal y desplazamiento en el tope correspondiente a la formación de rótulas plásticas en vigas, columnas y la aparición del primer elemento colapsado. Se concluye que el reforzamiento mediante el empleo de tejidos de PRFV modifica de manera favorable el desempeño de la edificación, ya que se incrementa la capacidad ante carga de sismo, se retrasa la formación del mecanismo de colapso y se mejora el nivel de desempeño con relación a la estructura sin reforzamiento
Enhancing Soccer-Specifc Motor Skills Through Visual Training: A Quasi-Experimental Study in Young Soccer Players
Authors: Bekris Evangelos , Gioldasis Aristotelis , Souglis Athanasios , Zacharakis Emmanouil , Smirniotou Athanasia
Published: September 2023

In team sports like soccer, the ability to make quick decisions is essential for successful performance. Playersmust perceive and understand the available aﬀordances in their environment to eﬀectively utilize the informationand make accurate decisions on the feld. Visual exploratory actions play a crucial role in acquiring the necessaryinformation, allowing players to anticipate action possibilities and plan their subsequent actions. This study aimed toevaluate the eﬀectiveness of an innovative training protocol based on visual exercises in improving soccer-specifcmotor skills of U12 soccer players. Thirty young male soccer players participated in the study and were randomlyassigned to one of three groups: Technique Group (T-G), Visual-Technique Group (VT-G), and Control Group (C-G).The T-G received technical training, the VT-G received the same training with the addition of visual stimuli, and theC-G received regular in-season training. Pre- and post-test measurements were conducted on soccer-specifc motorskills. The results showed that the VT-G demonstrated signifcant improvements in motor skills compared to the T-Gand C-G. These fndings suggest that incorporating targeted visual training into soccer training programs can enhanceperceptual-cognitive and visual skills, leading to improved agility and overall on-feld performance.Keywords: soccer, agility, visual training, youth sports, motor skills.
Organisatoriske særtrekk i samordningen mellom skole og arbeidsliv i yrkesfagutdanningen: Empirisk belysning gjennom en norsk casestudie
Authors: Rekdahl Merete Chatrin , Paulsen Jan Merok
Published: September 2023

The current study provides an in-depth investigation of critical factors of successful inter- organisational collaboration involving upper secondary schools, vocational communities situated at department levels, and labour market partners in the school’s local environment. The research question that has guided the study is: What are the organisational characteristics of schools and subject departments which are well-performing in terms of a high degree of student completion in vocational education and training? The concept of ‘organisational characteristic’ refers to structures, roles and institutionalised patterns of collaboration involving school teachers, school leaders and labour market partners. The study is designed as a single case study encompassing two units of analysis, embracing school and department levels in their interactions with partners in the labour market. The findings of the study highlight the importance of collaborative learning through the creation and development of specific organisational routines directed towards the core practices of vocational didactics. Moreover, the findings underscore the process of local adaptation activated at the subject- department level and directed towards corresponding businesses and relevant parts of the public sector. Implications for further research and practice are discussed.
Shank3 related muscular hypotonia is accompanied by increased intracellular calcium concentrations and ion channel dysregulation in striated muscle tissue
Authors: Yildiz Berra , Schiedt Lisa , Mulaw Medhanie , Bockmann Jürgen , Jesse Sarah , Lutz Anne-Kathrin , Boeckers Tobias M.
Published: September 2023

Phelan-McDermid syndrome (PMS) is a syndromic form of Autism Spectrum Disorders (ASD) classified as a rare genetic neurodevelopmental disorder featuring global developmental delay, absent or delayed speech, ASD-like behaviour and neonatal skeletal muscle hypotonia. PMS is caused by a heterozygous deletion of the distal end of chromosome 22q13.3 or SHANK3 mutations. We analyzed striated muscles of newborn Shank3Δ11(−/−) animals and found a significant enlargement of the sarcoplasmic reticulum as previously seen in adult Shank3Δ11(−/−) mice, indicative of a Shank3-dependent and not compensatory mechanism for this structural alteration. We analyzed transcriptional differences by RNA-sequencing of muscle tissue of neonatal Shank3Δ11(−/−) mice and compared those to Shank3(+/+) controls. We found significant differences in gene expression of ion channels crucial for muscle contraction and for molecules involved in calcium ion regulation. In addition, calcium storage- [i.e., Calsequestrin (CSQ)], calcium secretion- and calcium-related signaling-proteins were found to be affected. By immunostainings and Western blot analyses we could confirm these findings both in Shank3Δ11(−/−) mice and PMS patient muscle tissue. Moreover, alterations could be induced in vitro by the selective downregulation of Shank3 in C2C12 myotubes. Our results emphasize that SHANK3 levels directly or indirectly regulate calcium homeostasis in a cell autonomous manner that might contribute to muscular hypotonia especially seen in the newborn.
A randomized control trial to assess optical coherence tomography parameters of the Xlimus drug-eluting stent: the XLIMIT trial
Authors: Testa Luca , Squillace Mattia , Ventrella Nicoletta , Moreno Raul , Jiménez-Valero Santiago , Serra Antoni , Gomez Hospital Joan Antoni , Bellamoli Michele , Popolo Rubbio Antonio , Bedogni Francesco
Published: September 2023

Background

Third generation drug-eluting stents (DES) potentially offer better technical performance and reduced neointimal proliferation than previous generation DES. The XLIMIT non-inferiority trial evaluated the performance of the Xlimus (a novel sirolimus-eluting coronary stent system) in terms of endothelialization and tissue healing compared to the bioresorbable polymer Synergy DES.

Methods

A total of 177 patients undergoing percutaneous coronary intervention (PCI) were randomized in a 2:1 ratio (2 Xlimus: 1 Synergy). The primary endpoints, defined as the in-stent neointimal volume weighted by the sum of the lengths of the implanted stent (ISNV) and the in-stent neointimal percent volume obstruction (%VO) were evaluated at 6–9 months by means of optical coherence tomography (OCT). Additional OCT parameters as well as clinical endpoints were also collected.

Results

Most of the patients were males (77.4%), and the mean age was 64 years. One third of the population had stable angina/silent ischemia. A total of 300 stents (237 lesions) were analyzed: 198 (152 lesions) were in the Xlimus group, and 102 (85 lesions) in the Synergy group. The ISNV in the Xlimus group was 30.7 ± 24.5 mm3 while in the Synergy group it was 26.5 ± 26.7 mm3: the difference between the two means was 0.08 (−0, 04–0, 45), p = 0.018, thus meeting the non-inferiority hypothesis. The %VO was 16.3% ± 10.4% and 13.3% ± 10.8% in the Xlimus and Synergy groups, respectively: the difference between the two means was 3.0 (−0, 06–4, 2), (p = 0.01), thus meeting the non-inferiority hypothesis. No difference was found with respect to the secondary OCT endpoints as well as for clinical endpoints.

Conclusions

The study results confirm that the biological interaction of the Xlimus and Synergy DES with the coronary artery is comparable, and that translates in very reassuring OCT parameters at follow-up: as such, the Xlimus is non-inferior to the Synergy.

Clinical Trial Registration

ClinicalTrials.gov, identifier (NCT03745053).
Development of early warning system for tsunamis accompanied by collapse of Anak Krakatau volcano, Indonesia
Authors: Ratnasari Rinda Nita , Tanioka Yuichiro , Yamanaka Yusuke , Mulia Iyan E.
Published: September 2023

Present tsunami warning systems have been specialized for earthquake-generated tsunamis, but rapidly evaluating the tsunamis caused by volcanic eruptions and/or volcanic sector collapses remains a challenge. In this study, we applied a numerical model to the 2018 Anak Krakatau tsunami event, which was generated by the sector collapse, investigated a tsunami prediction skill by the model, and developed a real-time forecasting method based on a pre-computed database for future tsunamis accompanied by such eruption of Anak Krakatau. The database stores spatiotemporal changes in water surface level and flux, which are simulated under various collapse scenarios, for confined areas in the vicinity of potential source. The areas also cover the locations of observation stations that are virtually placed on uninhabited island surrounding the source area. During an actual volcanic tsunami event, a tsunami is expected to be observed at the observation stations. For real-time tsunami forecasting, the most suitable scenarios to reproduce the observed waveforms are searched quickly in the database. The precomputed results under the identified scenarios are further provided as input for rapid tsunami propagation simulation. Therefore, an effective real-time forecasting can be conducted to densely populated coastal areas located at a considerable distance from the source, such as the coasts of Java and Sumatra. The forecasting performance was examined by applying the method for three hypothetical collapse scenarios assuming different sliding directions. We demonstrated that the tsunamis along the coasts were successfully forecasted. Moreover, we showed that the combination of a pre-computed database and the existence of observation stations near the source area was able to produce appropriate tsunami forecasting for the coastal area even in a volcanic event.
Visual analysis of lung neuroendocrine tumors based on CiteSpace knowledge graph
Authors: Guo Mingjie , Hu Shaowen , Xiao Yaifei , Cao Zhan , Huang Zhichao , Liu Yalong , An Xiaokang , Zhang Guoyu , Zheng Xianjie
Published: September 2023

Objective

The relevant literatures in the field of pulmonary neuroendocrine tumor were analyzed to understand the lineage, hot spots and development trends of research in this tumor.

Method

The Web of Science core collection was searched for English-language literature about neuroendocrine tumors of the lung published between 2000 and 2022. CiteSpace software was imported for visualization analysis of countries, institutions, co-cited authors and co-cited journals and sorting of high-frequency keywords, as well as co-cited references and keyword co-occurrence, clustering and bursting display.

Results

A total of 594 publications on neuroendocrine tumours of the lung were available, from 2000 to 2022, with an overall upward trend of annual publications in the literature. Authors or institutions from the United States, Italy, Japan and China were more active in this field, but there was little cooperation among the major countries. Co-cited references and keyword co-occurrence and cluster analysis showed that research on diagnostic instruments, pathogenesis, ectopic ACTH signs, staging and prognosis and treatment was a current research hotspot. The keyword bursts suggested that therapeutic approaches might be a key focus of future research into the field for pulmonary neuroendocrine tumors.

Conclusion

Over these 20 years, research related to neuroendocrine tumors of the lung has increased in fervour, with research on diagnostic instruments, pathogenesis, ectopic ACTH signs, staging and prognosis, and treatment being the main focus of research. Therapeutic treatments may be the future research trend in this field.
Impact of the TLR4 agonist BECC438 on a novel vaccine formulation against Shigella spp.
Authors: Lu Ti , Das Sayan , Howlader Debaki R. , Jain Akshay , Hu Gang , Dietz Zackary K. , Zheng Qi , Ratnakaram Siva Sai Kumar , Whittier Sean K. , Varisco David J. , Ernst Robert K. , Picking William D. , Picking Wendy L.
Published: September 2023

Shigellosis (bacillary dysentery) is a severe gastrointestinal infection with a global incidence of 90 million cases annually. Despite the severity of this disease, there is currently no licensed vaccine against shigellosis. Shigella’s primary virulence factor is its type III secretion system (T3SS), which is a specialized nanomachine used to manipulate host cells. A fusion of T3SS injectisome needle tip protein IpaD and translocator protein IpaB, termed DBF, when admixed with the mucosal adjuvant double-mutant labile toxin (dmLT) from enterotoxigenic E. coli was protective using a murine pulmonary model. To facilitate the production of this platform, a recombinant protein that consisted of LTA-1, the active moiety of dmLT, and DBF were genetically fused, resulting in L-DBF, which showed improved protection against Shigella challenge. To extrapolate this protection from mice to humans, we modified the formulation to provide for a multivalent presentation with the addition of an adjuvant approved for use in human vaccines. Here, we show that L-DBF formulated (admix) with a newly developed TLR4 agonist called BECC438 (a detoxified lipid A analog identified as Bacterial Enzymatic Combinatorial Chemistry candidate #438), formulated as an oil-in-water emulsion, has a very high protective efficacy at low antigen doses against lethal Shigella challenge in our mouse model. Optimal protection was observed when this formulation was introduced at a mucosal site (intranasally). When the formulation was then evaluated for the immune response it elicits, protection appeared to correlate with high IFN-γ and IL-17 secretion from mucosal site lymphocytes.
Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1
Authors: Sanz Marta , Weideman Ann Marie K. , Ward Adam R. , Clohosey Matthew L. , Garcia-Recio Susana , Selitsky Sara R. , Mann Brendan T. , Iannone Marie Anne , Whitworth Chloe P. , Chitrakar Alisha , Garrido Carolina , Kirchherr Jennifer , Coffey Alisha R. , Tsai Yi- Hsuan , Samir Shahryar , Xu Yinyan , Copertino Dennis , Bosque Alberto , Jones Brad R. , Parker Joel S. , Hudgens Michael G. , Goonetilleke Nilu , Soriano-Sarabia Natalia
Published: September 2023

Antiretroviral therapy (ART) is not curative due to the existence of cellular reservoirs of latent HIV-1 that persist during therapy. Current research efforts to cure HIV-1 infection include “shock and kill” strategies to disrupt latency using small molecules or latency-reversing agents (LRAs) to induce expression of HIV-1 enabling cytotoxic immune cells to eliminate infected cells. The modest success of current LRAs urges the field to identify novel drugs with increased clinical efficacy. Aminobisphosphonates (N-BPs) that include pamidronate, zoledronate, or alendronate, are the first-line treatment of bone-related diseases including osteoporosis and bone malignancies. Here, we show the use of N-BPs as a novel class of LRA: we found in ex vivo assays using primary cells from ART-suppressed people living with HIV-1 that N-BPs induce HIV-1 from latency to levels that are comparable to the T cell activator phytohemagglutinin (PHA). RNA sequencing and mechanistic data suggested that reactivation may occur through activation of the activator protein 1 signaling pathway. Stored samples from a prior clinical trial aimed at analyzing the effect of alendronate on bone mineral density, provided further evidence of alendronate-mediated latency reversal and activation of immune effector cells. Decay of the reservoir measured by IPDA was however not detected. Our results demonstrate the novel use of N-BPs to reverse HIV-1 latency while inducing immune effector functions. This preliminary evidence merits further investigation in a controlled clinical setting possibly in combination with therapeutic vaccination.
Case Report: Unedited allogeneic chimeric antigen receptor T cell bridging to conditioning-free hematopoietic stem cell transplantation for a child with refractory Burkitt lymphoma
Authors: Yang Xiaomin , Luo Chengjuan , Qian Juan , Huang Xiaohang , Zhang Jian , Wang Jianmin , Luo Changying , Qin Xia , Li Benshang , Chen Jing
Published: September 2023

Purpose

Burkitt lymphoma (BL) is the most common tumor of non-Hodgkin’s lymphoma (NHL) in children, accounting for about 40% of cases. Although different combined short-course chemotherapies have achieved a good effect, refractory/relapsed BL has a poor prognosis with cure rates less than 30%. Chimeric antigen receptor T cell (CAR-T) therapy has developed rapidly in recent years and achieved excellent results in acute lymphoblastic leukemia (ALL). However, in some cases, there is a failure to produce autologous CAR-T cells because of T-cell dysfunction. In such cases, allogeneic CAR-T therapy has to be considered.

Methods

A 17-year-old boy with stage II BL did not respond to extensive chemotherapy and sequential autologous CAR-T therapy. Lentiviral vectors containing anti-CD20-BB-ζ (20CAR) and anti-CD22-BB-ζ (22CAR) transgenes were used to modify the T cells from an HLA-identical matched unrelated donor. Flow cytometry was used to assess the cytokine analyses and CAR-T cell persistence in peripheral blood, enumerated by qPCR as copies per ug DNA. Informed consent for autologous/allogeneic CAR-T therapy was obtained from the patient and his legal guardian.

Results

Unedited HLA-matched allogeneic CD20 and CD22 CAR-T cells were infused after lymphodepletion chemotherapy with cyclophosphamide and fludarabine. The patient experienced Grade IV cytokine release syndrome (CRS) and went into complete remission (CR) after anti-inflammatory treatment including tocilizumab. Because of persistent pancytopenia and full donor chimerism, the same donor’s conditioning-free peripheral blood stem cells were successfully transplanted 55 days post CAR-T. Neutrophils were engrafted at day +11 and platelets were rebuilt at day +47 without obvious acute graft-versus-host disease (GVHD), but there was mild chronic GVHD in the skin and eyes. Currently, active anti-rejection therapy is still underway.

Conclusion

Unedited HLA-matched allogeneic CAR-T cell therapy could be an innovative, effective, and safe treatment for children with refractory/relapse BL without obvious acute GVHD. Conditioning-free allogeneic hematopoietic stem cell transplantation (HSCT) from the same donor is feasible for a patient with full donor T-cell chimerism after allogeneic CAR-T. It cannot be ignored that close GVHD monitoring is needed post HSCT.