bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Diazaspirocycles for MRCK Inhibitors as Anti-cancer Agents
Authors: Ruscetta Vanessa
Published: June 2024

In the quest for new therapeutics targeting the metastatic spread of cancer, the synthesis of novel inhibitors for underexplored kinases is at the forefront. Recently, potent and selective inhibitors for a new cancer therapy target in the myotonic dystrophy-related Cdc42-binding kinases (MRCK) have been discovered for the treatment of aggressive cancers. The inhibitors feature a diazaspirocycle that significantly influences potency. While spirocycles are privileged scaffolds in medicinal chemistry, synthetic methods for their construction are limited, and asymmetric methods are in demand to access single enantiomers for biological applications. This work highlights the design and synthesis of diazaspirocycles for MRCK inhibition, focusing on the development of efficient asymmetric methods. Substituted α-amino nitriles are employed as key building blocks to expand the parent heterocycle into the desired bicyclic structure through haloalkylation, reductive cyclization, or direct reductive amination. Chiral directing groups, including naturally occurring menthol and amino alcohols, are assessed for their ability to access the desired enantiomer necessary for MRCK inhibition. The synthetic pathway designed can be applied to a wide range of substrates to create novel spirocyclic inhibitors in the future. As a result, the asymmetric construction of innovative spirocycles for MRCK inhibition opens the door for the discovery of modern therapeutics targeting the spread of aggressive cancers.
Supramolecular Synthesis of Hybrid Metal-Organic Framework-Dye Composites as Bioimaging Probes
Authors: Trifoi Lavinia
Published: June 2024

Fluorescence microscopy enables the visualization of complex biological systems and processes. However, the utilization of organic dyes as bioimaging agents presents several challenges such as stability in biological environment, reduced photostability, and lower quantum yields. Substantial effort has gone into the improvement of the photophysical properties of biocompatible fluorescent molecules (fluorophores).1,2Metal-organic frameworks (MOFs) are crystalline materials comprised of metal ion clusters linked by organic ligands. These nanomaterials are characterized by their large surface area, high porosity, tailorable a priori chemical design and post synthetic tunability. Selective encapsulation of fluorophores in porous nanoparticles to form emissive nanocomposite materials results in increased dye photostability and quantum yields, longer lifetimes, and better organization of the dye molecules, meanwhile providing a convenient solution to issues related to the low biocompatibility or scarce solubility of the dyes in physiological buffer. Furthermore, post synthetic functionalization of the nanostructures with targeting agents can direct precise accumulation within cells via endocytosis. In principle, this simple protocol can evolve into a general strategy to deliver intracellularly functional molecular components for targeted bioimaging applications.
Genomic Approaches to Studying Transcription in the Protozoan Model Tetrahymena Thermophila
Authors: Wahab Suzanne
Published: June 2024

This aim of this research is to increase understanding on the process of transcription regulation using the model organism Tetrahymena thermophila. In the first aim of this research, I used the proteomic approach of affinity purification followed by mass spectrometry (AP-MS) in order to establish the conserved protein Anqa1 as a member of a MuvB-like complex in Tetrahymena. AP-MS identified high confidence interactions with Lin9 and RebL1, reinforcing the idea that these three proteins represent the core of a putative MuvB complex. AP-MS revealed interactions with other proteins such as the transcription factor MybL1, suggesting a potential formation of the activator MMB complex in Tetrahymena as seen in the interaction between MuvB and B-MYB in mammals. As part of this aim I also used Chromatin Immunoprecipitation followed by high-throughput sequencing (ChIP-Seq) to detect Anqa1 binding sites and provide insight to its function, which helped discover a potential role of Anqa1 in transcription regulation. In the second aim of this research, to assist in the future characterization of the Mediator subunit Med31, I engineered a functional Med31-BirA* strain of Tetrahymena towards proximity labelling of Mediator associated proteins.
Cutting from the Bottom: Reform and Hospital Work Under the Influence of New Public Management
Authors: Virdo Guytano
Published: June 2024

Health care research predominantly analyzes the role of pharmaceuticals and physicians. Less focus is given to the majority of workers who are essential to the health care system. While often ignored, the non-physician work force has a large impact on health care financing and health care outcomes. Their work and the context they work in needs to be analyzed to provide a fuller understanding of health care systems. This dissertation is an attempt to fill this gap in health research. Hospital work exists in a complicated political context. Hospitals in Canada are privately operated, non-profit corporations that are publicly funded directly by provincial governments and indirectly by the federal government. Both levels of government have attempted to constrain health care spending in the last few decades, and much of this reduction was aimed at non-physician hospital workers and services. This dissertation utilized theories from public administration and sociology to contextualize hospital work within large political shifts and how they have impacted hospital work. These theories guided the literature review, the interview schedule, and the analysis and interpretation of the data. This dissertation examined the impact of health care reform on hospital work. Semi-structured interviews were utilized to ask hospital workers about their work, work-life balance, and how hospital work has changed over their careers. In total, 20 hospital workers were interviewed, including 10 nurses and 10 non-nurse workers. Interviews ranged from 30 to 65 minutes. Most respondents were from hospitals downtown Toronto, with the remaining working in hospitals within the Greater Toronto Area. This dissertation found that successive waves of health care reform have negatively impacted hospital work. Workers indicated various ways that the changing political and economic climate has impacted their lives and their ability to perform their work at a high level. In general, workers cited lowered autonomy, increased automation and documentation, and increased managerial control over their work. Workers also reported work intensification and high rates of injury. Workers pointed to budget cuts and a shift in accountability down to the workers to explain why these changes had occurred.
Pivoting During the Time of COVID-19: The Implementation of an Online Writing Program
Authors: Torsein Annabelle
Published: June 2024

Expressive writing is associated with gains in clinical and non-clinical populations. Expressive writing has been particularly effective with vulnerable populations that may lack access to services. The Writers Collective of Canada (WCC) offers expressive writing workshops aimed at reducing social isolation for those in marginalized communities. COVID-19 required WCC to pivot their original program offerings of inperson workshops to virtual workshops. Given the dearth of information regarding the effectiveness of synchronous online expressive writing groups, a program evaluation of the online program was conducted. This project was a mixed-methods implementation evaluation that utilized the consolidated framework for implementation research (CFIR) approach and consisted of three studies. Study 1 was an implementation qualitative case study. Study 2 was a mixed method utilization-focused evaluation (UFE) that focused on attendees of closed-registration workshops. Study 3 was a mixed method UFE that focused on attendees and facilitators of open-registration workshops. Data collection for all three studies occurred between June 2020 and May 2021. For the implementation case study, interviews with stakeholders (N = 6) were conducted to delineate WCC's implementation process, looking at all five CFIR domains. The focus of the mixed-method UFEs was reflecting and evaluating, a subcategory of the final CFIR domain. Similar results were found across both the closed- and open-registration participants. Quantitative data showed participants of closed-registration groups (attendees: N = 21) and open-registration groups (attendees: N = 17, facilitators: N = 23) endorsed improvement across outcomes and found the program to be acceptable. Qualitative data captured information regarding what worked well, issues that impacted participation, and suggested changes. The quantitative data demonstrated that attendees of both groups endorsed change in the areas queried, including hope, creativity, connection with others, self-expression, writing abilities, empowerment of voice, and leadership skills. Facilitators of the open-registration groups endorsed change in the areas queried, including satisfaction, creativity, connection with others, compassion, writing abilities, wellbeing, and leadership skills. The results from this study may be helpful for those considering offering online expressive writing workshops. The results of this evaluation can be a useful tool for WCC as they continue to grow their reach.
Stereotypes of Addiction in the United States: A Descriptive and Experimental Approach to Identifying Addiction Stereotypes and the Effectiveness of Positive-Counterstereotype Stigma-reduction Tactics
Authors: Pejic Samantha
Published: June 2024

Millions of individuals worldwide are affected by addiction, and stigma has been identified as a major barrier to recovery. However, the addiction literature has primarily researched addiction stigma broadly, with little information about distinct, drug-specific perceptions that permit the development of tailored interventions. This thesis extends the research by developing a comprehensive catalogue of perceptions of drug addictions and further examined one way these descriptions can be leveraged for social good. Across four studies (N = 451), I developed an adjective list appropriate for use with substance use disorder research (Pilot study). This list was used to catalogue the most stereotypical and counter-stereotypical adjectives associated with 14 drug categories (Study 1a), and further classify them according to valence (Study 1b). Finally, I tested whether a tailored, positive counter-stereotypic intervention was effective in reducing negative perceptions towards people addicted to cocaine (Study 2). The downstream consequences of these findings are discussed.
#cantbuymysilence: A Case Study and Intersectional Analysis on Non-disclosure Agreement (NDA) Legislation
Authors: Westall Kelsey
Published: June 2024

The #MeToo movement that originated in 2017 has drawn attention to the problem of sexual misconduct in workplaces globally. This problem includes the prevalent use of nondisclosure agreements (NDAs) to perpetuate misconduct and conceal acts of wrongdoing. In response, legislatures in different countries have introduced acts with varying degrees of scope. Thus, two questions remain: how do these policies impact individuals with different intersecting identities, and how can these policies be improved? Using a case study and multi-level approach that draws on gender and intersectional policy analyses, this MRP answers these questions by examining four different subnational jurisdictions in Canada and the United States. The results demonstrate varying degrees of effective legislation, which lead to the central argument that legislatures should consider a total ban on the use of NDAs in cases of harassment and discrimination. The MRP concludes by providing recommendations for future policy development in the Canadian context.
Opportunities and Barriers to the Delivery of Place-based Environmental Education During Emergency and Non-emergency Teaching: An Information and Communication Technology Approach
Authors: Borisenoka Inga
Published: June 2024

Place-based environmental education (PBEE) can enrich environmental education outcomes for youth through direct contact with nature. However, PBEE in K-12 can face barriers, some of which have been exacerbated during emergency teaching protocols, as observed during the COVID-19 pandemic. This research investigates K-12 teachers' perspectives on the potential of leveraging information and communication technology (ICT) to support PBEE during emergency and non-emergency teaching. Survey (n=122) and focus group (n=24) findings identify barriers and opportunities to PBEE before and after emergency protocols and how teachers view the use of ICT in PBEE. There was a negative association between PBEE frequency and grade level taught. The emergency protocols decreased time availability to plan for PBEE due to other work responsibilities. There were more references about potential positive aspects of ICT in PBEE than negative. Nevertheless, teachers emphasized that ICT use should be intentional and limited to allow students to engage thoroughly with the environment. 
Impacts of the King Street Priority Corridor on Environmental Perceptions: Gender, Mobility and Safety
Authors: Hoyos-Hoyos Sarah
Published: June 2024

In Toronto Ontario, infrastructure changes were implemented to improve public streetcar use within the King Street Transit corridor. There exists a link between how people perceive the environment and their travel behaviour. This research focuses on changes to perceived safety, the environment and if changes were perceived differently by each gender. Intercepted travellers, residents and local employees (n=548) completed a survey about environmental perceptions and travel behaviours. Binary logistic regression analyses examined the effect of multiple factors on gender and safety, and full multi-variate logistic regression was conducted to identify key measures of perceptions. Gender did not have an association with perceived safety or environmental factors. There were several significant relationships (CI=95%, p=0.0001) between environmental perceptions and mobility. The logistic multivariate analysis for safety and built environment, included rated air quality, noise levels, transit system rating, car ownership, and the likelihood of walking to work as positive predictors of mobility.
Identity crisis? News reports on invasive species feature misleading images of unrelated organisms
Authors: Wong Mark
Published: June 2024

In mainstream media, news outlets play a vital role in raising awareness and rallying public support for managing invasive species. However, news reports on invasive species occasionally feature misleading images of unrelated organisms. In this correspondence, I illustrate the problem with recent international news reports on invasions by Red Imported Fire Ants (Solenopsis invicta) in Asia, Australia and Europe. I discuss the serious implications of such misrepresentation for public understanding and support for invasive species management. I highlight ways ecologists can engage effectively with journalists to mitigate the spread of taxonomic misinformation in mainstream media.
Heat tolerance and its plasticity in freshwater and marine fishes are linked to their thermal regimes.
Authors: Verberk Wilco , Henry Erin , Leiva Felix , Barbarossa Valerio , Schipper Aafke
Published: June 2024

Responses to climate change are rooted in thermal physiology, and many studies have focussed on heat tolerance and plasticity of heat tolerance. Latitudinal patterns in heat tolerance are commonly considered to reflect latitudinal differences in thermal regimes, but direct tests are few. Here we show that the extremes and fluctuations in habitat temperature explain variation in heat tolerance of freshwater and marine fishes. Furthermore, we found that freshwater fish exhibit greater plasticity in heat tolerance than their marine counterparts. This reflects that, compared to marine fishes, freshwater fishes are exposed to greater thermal fluctuations. Our findings underscore the importance of thermal physiology for predicting responses to climate change and highlight that plasticity in heat tolerance is an important mechanism to cope with thermal extremes, especially for organisms living in thermally variable habitats such as freshwater fish.
The Impact of Startup Mentoring Programs on the Entrepreneurial Intention of Startup Projects in Central Vietnam
Authors: Toan K. Hoang  , Huan V. Nguyen  , Giang T. Tran Thi
Published: June 2024

This research evaluates the impact of startup mentoring programs on the intention to start new venture creation of startup projects in central Vietnam. The research data was collected from a survey of 250 mentees participating in mentoring programs organized in provinces in the central region of Vietnam. The results of the research show that the mentoring program has an impact on 5 factors leading to the entrepreneurial intention of mentees in descending order, including: Financial Management Skills, Strategic Thinking, Team Building Skills, Visionary Thinking, and Communication Skills. The research results also show that the mentoring program does not have enough impact on Risk Taking Capabilities to lead to the entrepreneurial intention of mentees.
Life is so Short, Future is so Long: The Relationship between Life History Strategies and People’s Metaphorical Perspectives on Time
Authors: Qin Yutian
Published: June 2024

Accruing evidence has attested to the plasticity of people’s metaphorical perspectives on the movement of events in time, which oscillate between the ego-moving perspective and the time-moving perspective contingent on, among others, perception of distance to the future by virtue of individual differences in lifestyle and personality. Building on and extending this avenue of inquiry, the current research investigated the relationship between life history strategy, another time-related construct, and the preferred perspective in the resolution of a temporally ambiguous question. Studies based on self-report (Study 1) and behavioral (Study 2) measures showed consistent results, such that individuals with a fast life history strategy and those who preferred the smaller-sooner reward tended to adopt the ego-moving perspective, whereas individuals with a slow life history strategy and those who preferred the larger-later reward tended to adopt the time-moving perspective. Examination of the priming effect of temporal perspectives on intertemporal decision-making revealed that differential perceptions of temporal distance underlay the strategy-time relationship (Study 3). Taken as a whole, the current findings suggested that individual differences in life history strategy may also influence people’s preferred perspective in the interpretation of ambiguous language related to time.
Oradour-sur-Glane : l’étude d’une rumeur, levier ou obstacle pour l’enseignement ?
Authors: Gomes Lucie
Published: June 2024

Every year, thousands of students and their teachers visit the martyred village of Oradour-sur-Glane in Haute-Vienne, in the center of France. This article raises the question of the levers and obstacles for learning from the observation of three visits, bringing out the importance of a rumor on the reasons for this massacre at the end of the Second World War. First seen as an obstacle preventing us from understanding the event, the rumor is studied differently to imagine how to use it as levers for problematized historical learnings articulating history and memory.
Zwischen Emotionalität und Rationalität: die Hellespont-Brücken 480 v. Chr.
Authors: Scholten Helga
Published: June 2024

In 480 BC, the Persian Great King Xerxes ordered the construction of ship bridges across the Hellespont to enable his army to cross from Asia to Europe. A storm destroyed the first construction, so Xerxes had the sea insulted and flogged. The campaign ended with a victory for the Greeks. Both Aeschylus’ drama « The Persians » and Herodotus’ « Histories » contain references to the perception of the technical achievement of the 1,2 km long bridge construction. The article deals with the different perceptions, the emotional as well as rational assessments of such a technical intervention in nature.
La révolution industrielle : une histoire symbiotique
Authors: Fressoz Jean-Baptiste
Published: June 2024

In its standard version, the « industrial revolution » would be the story of an energy transition from wood to coal. However, in the 19th century, the consumption of wood, including firewood, increased in most countries. In addition, the extraction of coal was itself very timber-consuming. It is therefore necessary to tell the story of energy as a process of « energy symbiosis » and that of the industrial revolution not as a transition but as an amplification of all materials.
Ein Fanal gegen «ökologisch unverantwortbar[e]» Technik: die Selbstverbrennung des Atomkraftgegners Hartmut Gründler 1977
Authors: Meyer Jan-Henrik
Published: June 2024

Hamburg, November 1977. An anti-nuclear activist sets himself alight. Hartmut Gründler’s self-immolation demonstrates the fiercely contested nature of nuclear technology at the time. It was staunchly supported by some as the embodiment of innovative technology while being firmly rejected by others as overly dangerous and risky. Zooming in on Gründler, this contribution discusses his critique and motivation, the international examples he drew on and the logic of his protest, his failure and afterlife. It offers some suggestions for history education regarding technology, innovation, and change.
Les « Trente Glorieuses » au crible d’une histoire environnementale des pollutions en Suisse
Authors: Kissling Florian
Published: June 2024

The concept of the « Trente Glorieuses » has profoundly marked the historical representations of the second half of the twentieth century and the teaching of this period. However, the notions of progress, economic growth and technical innovation, generally associated with this concept, produced effects that have long remained hidden. Environmental History makes it possible to nuance the sometimes sacralized depiction of these years. This article presents an educational module on the history of pollution in Switzerland. The conclusions and didactic reflections are produced thanks to an exercise carried out by students.
Faire enquêter les élèves sur et à partir de lacunes du savoir
Authors: Honoré Etienne
Published: June 2024

This paper reports on one aspect of an experimental teaching-learning system that aims to identify and characterize the conditions for the development, in history classes, of a dynamic of reflection indexed to the epistemology of the discipline. With this in mind, we are modelling the articulation between knowledge and ignorance, which is likely to guide a school inquiry, to observe students’ ability to problematize. The cases analyzed enable us to identify different strategies relating to the relationship between what is known and what needs to be known, so that a historical problem can be constructed or avoided.
Coexister avec les vers luisants Histoires d’anecdotes.
Authors: Chastant Boris
Published: June 2024

Les humains vivent aux côtés des vers luisants depuis plusieurs milliers d’années et l’intriguant insecte nocturne et bioluminescent n’a pas dû passer inaperçu. Pourtant, il n’existe que peu de traces historiques de ces rencontres anecdotiques qui, autrefois, étaient vouées à tomber dans l’oubli. En 2015, deux chercheurs en sciences naturelles ont lancé un programme de sciences participatives sur le territoire français visant à recenser les observations de vers luisants par le grand public. Désormais, des traces (numériques) s’accumulent et offrent des clés de compréhension de notre rapport à cet insecte qui médiatise des formes d’attachement et d’attention à un environnement intime, les jardins domestiques.
Live Action Role Playing (Larp) in Cognitive Behavioral Psychotherapy: A Case Study
Authors: Bartenstein Lennart
Published: June 2024

Role-play is an established tool in psychotherapy. Recent literature has indicated the similarities between live action role-playing (larp) and psychotherapy. In cognitive behavioral therapy (CBT), which is one of the most widespread therapeutic approaches, Role-play is a tool for developing desired target behavior (Fliegel 2020). This also applies to so-called skills groups in CBT. One form of these skills groups is the Gruppentraining sozialer Kompetenzen (Hinsch et al. 2015). Some literature has highlighted the similarities between role-playing methods used in CBT-oriented skills groups and larp (Aschenbrenner 2013, Balzer 2008). A deficit in social skills is associated with a variety of mental disorders (Segrin 2001). The use of a CBT-oriented larp may therefore be helpful in the treatment of several mental disorders. A standardised form of CBT-oriented larp in the sense of a clinical manual does not yet exist. There is also no empirical evaluation with questionnaires of such a therapeutic larp yet. This article presents the implementation and empirical evaluation of a standardised CBT-oriented larp. This clinical case study was conducted with 6 patients with mental disorders.Participants were aged 30 years or younger and all had at least one affective disorder. Established clinical screening questionnaires were used for assessment. Data were collected in a pre-post follow-up design. The study shows that this CBT-oriented larp is feasible with people with mental illness. Qualitative data show good goal attainment and positive experiences among participants. Short-term positive developments were also found in the screenings. However, an empirical statement about the effectiveness of the larp is not yet possible; in the long term, the screenings even show negative trends.
Participants were aged 30 years or younger and all had at least one affective disorder. Established clinical screening questionnaires were used for assessment. Data were collected in a pre-post follow-up design. The study showed that a CBT-oriented larp has positive effects on mental health, especially in the short term, and can be an effective component of conventional behavioral therapy in the long term.
Bleed and Identity: A Conceptual Model of Bleed and How Bleed-out from Role-playing Games Can Affect a Player’s Sense of Self
Authors: Hugaas Kjell Hedgard
Published: June 2024

The RPG concept bleed describes the spillover of physical states, mental states, physicality, values, opinions, and other similar concepts from player to character and vice versa. Over the years, numerous theorists have suggested several specific types of bleed, but how these suggested types stand in relation to each other has yet to be theorized. In order to create a foundation from which to better be able to study and conduct research on bleed, this article presents a conceptual model that places the previously suggested bleed types in relation to each other and to theories of identity creation in adjacent fields. The concept of the bleed perception threshold and the bleed complex of identity bleed is suggested as part of this model. The article then shows how theories concerned with identity creation from different fields such as psychology, social psychology, and neuroscience inform the model and how the model does not stand in opposition to them. Using the model and the presented theories as a starting point, the article makes suggestions about how bleed can affect a player’s sense of self.
Investigating the Effectiveness of Equine-assisted Therapy on Children Regardless of Their Mental Disorder
Authors: Ágoston Dorottya , Bozori Gabriella , Kiss Rita Mária
Published: June 2024

Equine-assisted therapy (EAT) is a common and popular complementary and alternative therapy among children with different mental disorders. In this study, the effectiveness of EAT was investigated on children with diverse mental disorders by analyzing their gait. Fifty-six children (age: 8.30 ± 3.77 years) were involved in the research who participated weekly in equine-assisted therapy during a school year. The gait of the children was measured twice with the GAITRite® pressure-sensing mat, before and after the therapy period. The participants did ten sections of walking on the pressure-sensing mat. Twenty-one spatial and temporal gait parameters were chosen and evaluated for further statistical analysis. To determine the normal distribution of the parameters, the Lilliefors normality test was carried out. Depending on the result, the paired t test or the Wilcoxon signed-rank test was used to compare the means of the results of the two measurements (p < 0.05). Significant differences were observed for eight out of the twenty-one parameters which investigation provides some promising results regarding the benefits of equine-assisted therapy for children's quality of life.
consolidação das avaliações em larga escala no cenário educacional brasileiro
Authors: Souza Davison da Silva , Costa Maria Aparecida Alves da , Silva Cicera Mônica Rodrigues da , Nunes Débora Thaís Rodrigues
Published: June 2024

Pensando a relação do Brasil com órgãos internacionais e a implicação dessa relação nas políticas educacionais, objetivamos compreender como as avaliações em larga escala influenciam a educação brasileira. No que tange ao arcabouço teórico-metodológico, a pesquisa é de caráter qualitativo (MINAYO, 2016; GATTI, 2006), tendo como técnica de coleta a investigação bibliográfica (BARROS, 2011). Utilizaremos a literatura de autores como Afonso (2009), Lima & Gandin (2019) e Pereira (2017). A partir da análise, observamos que as políticas educacionais voltadas às avaliações não são neutras, estando carregadas de ideologias que atendem aos anseios do sistema capitalista. Os órgãos internacionais financiam tais ações no Brasil e no mundo com um viés liberal, onde o intuito é capacitar mão de obra para o trabalho assalariado.
INTEGRATION OF SPIRITUAL VALUES IN SCIENCE LEARNING CONTENT AS AN EFFORT TO BUILD STUDENT CHARACTER FROM THE SCHOOL LEVEL
Authors: Henny Johan  , Agus Sundaryono  , Bhakti Karyadi  , Umaya
Published: June 2024

The concept of science has the potential to be explored in instilling spiritual values. Competence of a good science teacher is needed to integrate science learning and inculcate spiritual values. This PPM activity aims to provide knowledge and improve the competence of science teachers in presenting science learning activities that focus on cognitive abilities as well as spiritual attitudes. Community service activities (PPM) will be carried out in the form of workshop training involving students and science teachers in Rejang Lebong Regency, Bengkulu Province. Based on the results of the questionnaire, it is known that teachers and students agree on the need for the integration of spiritual values ​​through science learning. The results of the teacher's worksheet show the teacher is able to relate the concept of science to spiritual values of the greatness of God. The teacher can describe the plan for presenting these values ​​in learning activities. Students are very enthusiastic about learning science with spiritual values ​​and students are able to give examples of various phenomena related to the concept of physics and the spiritual values ​​in it. Based on the results of the response questionnaire and working papers, it can be concluded that students and teachers are highly motivated by learning science with spiritual values. After participating in the workshop, the teacher can integrate spiritual values ​​into basic competencies in science learning. Students are able to mention spiritual values ​​in various phenomena related to scientific concepts.
SOSIALISASI PENGOLAHAN MINYAK JELANTAH MENJADI SABUN CUCI
Authors: Hermansyah Amir  , Hersy Khosyati  , Intan Putri Utami  , Nining Febri Busraningsih  , Novri Hemdi Saputra  , Okta Rahmadany Arkanshi  , Perti Ulandari  , Ranti Oktiandi  , Sekar Chairunisa Regianti  , Shelvyna Woulandari  , Yenni Anggriani
Published: June 2024

Kegiatan pengabdian kepada Masyarakat dilakukan di JL. Melinjo RT 01 RW.01 Kel. Kandang Kota Bengkulu, dengan peserta para ibu-ibu PKK. Kegiatan ini bertujuan untuk memberikan informasi tentang pemanfaatan limbah minyak jelantah sebagai bahan baku produk sabun yang bernilai dan episien untuk rumah tangga. Kegiatan dilakukan melalui sosialisai pembuatan produk sabun. Kegiatan diikuti oleh 20 orang ibu-ibu PKK RT 01 RW.01 Kel. Kandang Kota Bengkulu  pada tanggal 27 April 2024  yang menunjukkan antusiasme terhadap sosialisasi yang ditampilkan. Diharapkan hasil sosialisasi yang dilakukan memberikan gambaran kepada masyarakat khususnya para ibu-ibu dilingkungan RT 01 RW.01 Kel. Kandang Kota Bengkulu untuk pengoptimalan limbah minyak jelantah yang ada . Selain itu, kegiatan ini dapat menjadi kegiatan  yang produktif dan memperdayakan masyarakat untuk mengolah dan memproduksi sabun dari limbah minyak jelantah serta diharapkan berdampak positif karena dapat memberikan alternative untuk menanggulangi penumpukan sampah dan pembuangan limbah yang tidak tepat, serta dapat membuka peluang usaha baru guna meningkatkan perekonomian masyarakat.
Kata kunci: minyak jelantah, sabun, penanggulangan limbah
Violación al principio de legalidad ante la presunción de embriaguez por negarse a realizar la prueba de alcoholemia.
Authors: Cornejo-Alarcón María
Published: June 2024

La conducción de vehículos en estado de embriaguez, es un tema social que nos aqueja en el Ecuador, por lo que dichas conductas se encuentran incorporadas en nuestra normativa jurídica. En este trabajo investigativo nos centraremos precisamente en el análisis del procedimiento que se le está dando a los casos de contravenciones de tránsito en los que se encuentran involucrados conductores en estado de embriaguez. Así al momento de la aprehensión se les conmina a que se practiquen la prueba de alcoholemia. Sin embargo, ante la negativa a la realización de esta prueba, así como del examen psicosomático, son llevados ante autoridad competente. De este modo son juzgados bajo la premisa de encontrarse en el máximo estado de embriaguez por haberse negado a la práctica de dichas pruebas.De lo expuesto, mi estudio está enfocado al análisis del procedimiento legal y juzgamiento que se está aplicando en estos casos. Así verificaré si se está garantizando el debido proceso y el derecho a la defensa, en cumplimiento al principio de legalidad del acusado.
Budget impact analysis of natalizumab biosimilar on pharmaceutical expenditure for the treatment of relapsing-remitting multiple sclerosis in Italy
Authors: Bergamaschi Roberto , Capobianco Marco , Ravasio Roberto
Published: June 2024

Background: The availability of high-efficacy disease-modifying therapy (DMT), including natalizumab, improved treatment efficacy in adults with highly-active relapsing-remitting multiple sclerosis (RRMS). Natalizumab patent protection has expired, and the natalizumab biosimilar (Tyruko®) has been recently reimbursed by AIFA. As the price of natalizumab biosimilar is expected to be lower as compared with natalizumab originator’s price, a budget impact analysis was conducted to assess the economic impact associated to the introduction of natalizumab biosimilar for patients with highly-active RRMS.
Methods: A budget impact model was developed, considering the INHS perspective and a 5-years time horizon. The number of patients treated with natalizumab was estimated based on historical natalizumab consumption data, disease prevalence rates and natalizumab market share. The budget impact population was divided into prevalent and incident patients. The model assumes that some patients in treatment with natalizumab originator will switch to natalizumab biosimilar and that some naïve patients will directly start treatment with natalizumab biosimilar. The ex-factory price of natalizumab originator (intravenous and subcutaneous) and biosimilar (intravenous) and the corresponding administration costs were included. All assumptions were validated by expert opinion.
Results: Eligible population was estimated at 7,552, 7,779, 8,090, 8,494 and 8,834 in years 1, 2, 3, 4 and 5 respectively. The introduction of natalizumab biosimilar, considering a progressive increase in market share from 9.6% (year 1) to 40.5% (year 5), would provide an overall savings (5-years time horizon) over € 47 million to the INHS. The scenario analysis highlights that the lower treatment cost of biosimilar natalizumab compared to originator natalizumab would offset the higher cost associated with intravenous versus subcutaneous administration.
Conclusion: Considering the results of this budget impact analysis, it is realistic to expect that the presence of biosimilar natalizumab will contribute to the sustainability of public pharmaceutical expenditure.
In vivo analgesic, anti-inflammatory, sedative, muscle relaxant activities, and docking studies of 3’,4’,7,8-tetrahydroxy-3-methoxyflavone isolated from Pistacia chinensis
Authors: Rauf Abdur , Rashid Umer , Akram Zuneera , Saeed Anees , Muhammad Naveed , Al Masoud Najla , Alomar Taghrid S. , Naz Saima , Iriti Marcello
Published: June 2024

Background: Pistacia chinensis is extensively employed in traditional medicine. This study aimed to isolate and evaluate the therapeutic effects of 3’4’78-tetrahydroxy-3-methoxyflavone from P. chinensis crude extract.
Materials and Methods: The study utilized column chromatography for isolation. The plant extract and its isolated compound were assessed for in vivo analgesic (hot plate model), anti-inflammatory (carrageenan-induced paw edema), sedative (open field model), and muscle relaxing properties (inclined plane and traction test).
Results: In the thermal-induced analgesic model, a significant analgesic effect was observed for the extract (25, 50, and 100 mg/kg) and the isolated compound (2.5, 5, 10, and 15 mg/kg) at higher doses. The extract (100 mg/kg) significantly prolonged latency time (21.98 seconds) after 120 minutes of administration. The isolated compound elevated the latency time (20.03 seconds) after 30 minutes, remaining significant up to 120 minutes with a latency time of 24.11 seconds. The anti-inflammatory effect showed a reduction in inflammatory reactions by 50.23% (extract) and 67.09% (compound) after the fifth hour of treatment. Both samples demonstrated significant sedative effects, with the extract hindering movement by 54.11 lines crossed compared to the negative control (180.99 lines). The isolated compound reduced the number of lines crossed to 15.23±SEM compared to the negative control. Both samples were also significant muscle relaxants. Docking studies indicated that the compound’s therapeutic effect is due to inhibiting COX and nociceptive pathways.
Conclusion: The isolated compound from Pistacia chinensis exhibits significant analgesic, anti-inflammatory, sedative, and muscle relaxing properties, with potential therapeutic applications by inhibiting COX and nociceptive pathways.
Surgical Treatment of Ruptured Aneurysms of Lateral Spinal Artery Presenting as Intracranial Subarachnoid Hemorrhage : Case Series and Literature Review
Authors: Song Yonghun , Lee Kwangho , Park Hyun , Hwang Soo Hyun , Baek Hye Jin , Park In Sung
Published: June 2024

Lateral spinal artery (LSA) aneurysms are extremely rare lesions that can rupture and cause subarachnoid hemorrhage (SAH) even though the spinal arteries communicate directly with the subarachnoid space. To date, six cases of LSA aneurysms have been reported in the literature. Herein, three such cases are reported. All patients presented to the emergency department with headaches. The patients in the first two cases were confirmed to have SAH and LSA aneurysms on a brain computed tomography (CT) angiography performed at the hospital. Two patients had prior instances of cerebral infarction and coronary disease, respectively, and were undergoing antiplatelet therapy. The antiplatelet medication was stopped for 2 weeks and 1 week, respectively, while conservative care was provided. Subsequently, a suboccipital craniectomy was performed, followed by aneurysm clipping. Following the surgery, both patients were discharged without any significant neurological deficits. Regarding the third patient, no aneurysm was found on brain CT angiography, and cerebral angiography was performed during the patient’s hospital stay. She was hospitalized, where she received medication and conservative care, and was discharged with an improvement in bleeding without neurological symptoms. Subsequently, a LSA aneurysm was identified on a brain CT angiography performed at an outpatient clinic; however, the patient was transferred because she wanted to be treated at another hospital. LSA aneurysms are difficult to visualize using CT angiography; therefore, careful angiographic studies are required. Surgical clipping is the treatment of choice if the aneurysm is inaccessible by the endovascular treatment.
Factores asociados al uso de métodos anticonceptivos en adolescentes de 4to. – 5to. de secundaria de dos Instituciones Educativas en el año 2022
Authors: Hurtado Soto Marjury Stheysi , Inacochea Cáceda Sonia
Published: June 2024

Objetivo: Determinar los factores asociados al uso de los métodos anticonceptivos enadolescentes de 4to y 5to de secundaria de dos Instituciones educativas de San Martín dePorres en el 2022. Métodos: Estudio observacional, transversal, analítico y cuantitativo. El tamaño de la muestra fue de 244 participantes. Se empleó una ficha de recolección de datos con una confiabilidad aceptable para el recojo de las variables planteadas para este estudio. El análisis estadístico se realizó con el programa estadístico SPSS versión 26.0. Para el análisis estadístico, se usó la prueba de chi cuadrado y la prueba no paramétrica de la U de Mann-Whitney. El valor de significancia estadística aprobado fue de p<0.05 con intervalos de confianza al 95%. Resultados: El 37.7% de los adolescentes ya ha iniciado actividad sexual de los cuales un 64.1% de adolescentes usan métodos anticonceptivos. Hubo asociación significativa (p<0.05) para el factor sociocultural: tener pareja sentimental. De aquellos que consumen alcohol, un 60.6% no usan métodos anticonceptivos. No hubo asociación significativa para el nivel de conocimiento, factores sociodemográficos, fuente de información y tipo de familia.Conclusiones: El factor asociado al uso de métodos anticonceptivos en adolescentes de 4to y5to de secundaria es: Tener pareja sentimental.
Fe de Erratas
Authors: Castillo-Urquiagal Walter , Huertas Tacchino Erasmo , Ingar Jaime , Ventura Laveriano Walter , Limay Rios Oscar , Gil Guevara Enrique
Published: June 2024

In the article “Placental insufficiency in term and post-term pregnancy with normal fetal growth and
adverse outcome” in the Peruvian Journal of Maternal Perinatal Research 2017 6 (2): 31-36.
Mortalidad Materna en el Instituto Nacional Materno Perinatal
Authors: Guevara Ríos Enrique
Published: June 2024

A nivel nacional, el número de muertes maternas disminuyó en el 2023. En el 2019 se produjeron 302 muerte maternas, cifra que nunca se había llegado en el Perú; lamentablemente la llegada de la pandemia por COVID-19 al Perú en el 2020, puso al descubierto graves deficiencias en el sistema de salud. Ese año el número de casos de muerte materna se incrementó a 439 (incremento del 45%) y el 2021 se incrementó a 493 (incremento del 63% respecto al 2019). En el 2022 luego de la vacunación de las gestantes contra el COVID-19 y mejoras en la calidad de atención materna, se logró disminuir los casos de muerte materna a 291 y en el 2023 a 264 casos (disminución del 13% aproximadamente respecto al año 2019)(1).
Pemberian edukasi pada usia remaja terhadap penyakit hipertensi
Authors: Amukti Danang Prasetyaning , Humolungo Dwi Tiva Widyanti Sidik , Ardilla Mita , Bachri Moch. Saiful , Ma'ruf Muhammad
Published: June 2024

Prevalensi penderita hipertensi di dunia sebesar 22% dan negara di kawasan Asia Tenggara berada di peringkat ke 3 tertinggi di dunia mengalami hipertensi. Hasil Riskesdas 2018 menunjukkan sebanyak 34,11% penduduk Indonesia mengalami hipertensi dan 20,1% diantaranya merupakan kelompok usia 18-24 tahun. Hipertensi pada remaja menjadi tantangan besar bagi keluarga di Indonesia dan merupakan masalah kesehatan masyarakat yang serius, karena jika tidak terkendali akan berkembang dan menimbulkan komplikasi berbahaya yang menyebabkan stroke, jantung koroner dan kematian. maka perlu dilakukan kegiatan pengabdian kepada remaja sekolah dalam bentuk edukasi kesehatan dan pemeriksaan faktor risiko hipertensi sebagai upaya potensi pencengahan hipertensi.Kegiatan program pemberdayaan umat (PRODAMAT) menggunakan metode Participatory Action Research (PAR). Metode Participatory Action Research (PAR) digunakan untuk menekankan partisipasi dan kolaborasi dari berbagai pihak dalam mengelola penelitian action research. Dalam penelitian ini kami ada beberapa langkah-langkah yang akan di lakukan mulai dari solusi atau gagasan yang di tawarkan, pihak yang di pertimbangkan untuk implementasi gagasan, dan langkah strategis implementasi.Hasil yang didapatkan setelah dilakukan pretest sebesar 64%. Dimana dari hasil yang didapatkan bahwa pengetahuan siswa terhadap hipertensi belum begitu paham. Setelah itu kemudian dilakukan pemaparan materi tentang pengobatan dan pencengahan hipertensi kepada siswa SMK Kesehatan Bantul. Kemudian dilanjutkan dengan sesi posttest pada akhir materi. Hasil yang didapatkan setelah dilakukan posttest sebesar 74%. Hasil ini menunjukkan adanya peningkatan pengetahuan dan pemahaman dari edukasi pengobatan dan pencengahan hipertensi yang perlu diterapkan pada kehidupan sehari-hari untuk mencengah terjadinya hipertensi pada usia remaja.
Optimization of Operation of Heavy Oil Residue Processing Units in Delayed Coking Processes
Authors: Shigapov R. , Nurieva E. , Sagdeeva G.
Published: June 2024

The delayed coking process is the most cost-effective and promising technology for processing oil residues and has become most widespread. Oil refineries that include ultrasonic treatment plants can be classified as plants with waste-free oil refining technology. The UZK includes coking and fractionation sections, a furnace block, a coke unloading block, a gas and naphtha separation block, a unit for collecting harmful emissions, a unit for purifying water separated from petroleum coke, a system inside the coke processing unit, a system for compressing and supplying wet gas and others auxiliary systems. The coking section consists of a furnace and 4 reactors operating in parallel to ensure process continuity. The main directions for optimizing the delayed coking process can be considered: changes in the composition of raw materials; improvement of coke chambers of the delayed coking unit; improvement of the fractionating column of the delayed coking unit; modernization of furnaces - the most resource-intensive element of the installation, delayed coking. Ceramic Coating of Furnaces – Applying highly emissive ceramic coatings to furnace coils and linings is an effective energy-saving measure. Allowing to significantly increase the efficiency of furnaces by increasing the thermal load of the radiant section of the furnace, and as a result, reduce fuel consumption.
Foreign Experience Managing Employees
Authors: Sarieva M. , Kadyrova B.
Published: June 2024

Recently, many modern organizations in our country have begun to use foreign experience in managing employees. This process can be called internationalization in the field of modern management. Such an organization of work with employees provides for the creation of all possible models at the enterprise, as well as the use of a systematic approach to the rational use of labor resources. Management decisions made by the owners are influenced by a number of factors that neither managers nor other employees of the company can influence. These factors are related not only to the internal processes of the company, but also to the external environment. These factors affecting employee management methods reflect the priority traditions of a particular society, therefore they acquire a different nature.