bluuebunny/crossref_metadata_2025 huggingface dataset:
An Association Study of HLA with the Kinetics of SARS-CoV-2 Spike Specific IgG Antibody Responses to BNT162b2 mRNA Vaccine
Authors: Khor Seik-Soon , Omae Yosuke , Takeuchi Junko S. , Fukunaga Ami , Yamamoto Shohei , Tanaka Akihito , Matsuda Kouki , Kimura Moto , Maeda Kenji , Ueda Gohzoh , Mizoue Tetsuya , Ujiie Mugen , Mitsuya Hiroaki , Ohmagari Norio , Sugiura Wataru , Tokunaga Katsushi
Published: April 2022

BNT162b2, an mRNA-based SARS-CoV-2 vaccine (Pfizer-BioNTech, New York, NY, USA), is one of the most effective COVID-19 vaccines and has been approved by more than 130 countries worldwide. However, several studies have reported that the COVID-19 vaccine shows high interpersonal variability in terms of humoral and cellular responses, such as those with respect to SARS-CoV-2 spike protein immunoglobulin (Ig)G, IgA, IgM, neutralizing antibodies, and CD4+ and CD8+ T cells. The objective of this study is to investigate the kinetic changes in anti-SARS-CoV-2 spike IgG (IgG-S) profiles and adverse reactions and their associations with HLA profiles (HLA-A, -C, -B, -DRB1, -DQA1, -DQB1, -DPA1 and -DPB1) among 100 hospital workers from the Center Hospital of the National Center for Global Health and Medicine (NCGM), Tokyo, Japan. DQA1*03:03:01 (p = 0.017; Odd ratio (OR) 2.80, 95%confidence interval (CI) 1.05–7.25) was significantly associated with higher IgG-S production after two doses of BNT162b2, while DQB1*06:01:01:01 (p = 0.028, OR 0.27, 95%CI 0.05–0.94) was significantly associated with IgG-S declines after two doses of BNT162b2. No HLA alleles were significantly associated with either local symptoms or fever. However, C*12:02:02 (p = 0.058; OR 0.42, 95%CI 0.15–1.16), B*52:01:01 (p = 0.031; OR 0.38, 95%CI 0.14–1.03), DQA1*03:02:01 (p = 0.028; OR 0.39, 95%CI 0.15–1.00) and DPB1*02:01:02 (p = 0.024; OR 0.45, 95%CI 0.21–0.97) appeared significantly associated with protection against systemic symptoms after two doses of BNT162b2 vaccination. Further studies with larger sample sizes are clearly warranted to determine HLA allele associations with the production and long-term sustainability of IgG-S after COVID-19 vaccination.
Metagenomic Characterization of Microbial Pollutants and Antibiotic- and Metal-Resistance Genes in Sediments from the Canals of Venice
Authors: Curran James F. , Zaggia Luca , Quero Grazia Marina
Published: April 2022

The spread of fecal pollutants and antibiotic resistance in the aquatic environment represents a major public health concern and is predicted to increase in light of climate change consequences and the increasing human population pressure on the lagoon and coastal areas. The city of Venice (Italy) is affected by diverse microbial pollution sources, including domestic wastewaters that, due to the lack of modern sewage treatment infrastructure in the historical city center, are released into canals. The outflowing jets of its tidal inlets thus represent a source of contamination for the nearby beaches on the barrier island separating the lagoon from the sea. Metagenomic analyses of DNA extracted from sediment samples from six sites in the canals of the city’s historic center were undertaken to characterize the microbial community composition, the presence of fecal microbes as well as other non-enteric pathogens, and the content of genes related to antibiotic (AB) and heavy metal (HM) resistance, and virulence. The six sites hosted similar prokaryotic communities, although variations in community composition likely related to oxygen availability were observed. All sites displayed relatively high levels of fecal contamination, including the presence of Fecal Indicator Bacteria, sewage- and alternative feces-associated bacteria. Relatively high levels of other potential pathogens were also found. About 1 in 500 genes identified at these sites are related to AB and HM resistance; conversely, genes related to virulence were rare. Our data suggest the existence of widespread sediment microbial pollution in the canals of Venice, coupled with the prevalence of ARGs to antibiotics frequently used in humans as well as of HMRGs to toxic metals that still persists in the lagoon. All of this evidence raises concerns about the consequences on the water quality of the lagoon and adjacent marine areas and the potential risks for humans, deserving further studies.
C7 contribution to the ulnar nerve
Authors: Pereira de Macêdo Lívio , Ugulino Netto Arlindo , Franke Kauê , Vansant Oliveira Eugenio Pierre , Ribeiro de Moraes Freitas Lucas , Antônio Serra de Lima Júnior Fábio , Romeiro de Paula João Vitor , Nery Bernardino Silvya , Morais de Souza Fernando Henrique , S. Almeida Nivaldo , Rocha Cirne Azevedo-Filho Hildo
Published: April 2022

Introduction. Classic anatomical literature frequently describes C7 contribution to ulnar nerve (UN) formation as a casual event. However, surgical practice and dissections frequently reveal a recurrent presence of a lateral cord component of the UN. This study aimed to seek through literature to establish the frequency and degree of this contribution.
Methodology. We ran a literature review searching on Pubmed, MEDLINE, Embase and Web of Science databases for ulnar nerve anatomy and described discursively the results.
Results and discussion. We found 9 articles that described quantitatively and qualitatively the contribution of C7 on the formation of the UN. The prevalence described ranged from 2 to 100%, depending on the methodology used and population characteristics. When present, studies described a contribution from 9,9% to 30,4%, sending even more fibres than T1 root on average.
Conclusion. The C7 root can be considered a frequent and important component of the ulnar nerve, explaining UN territory repercussions on C7 radiculopathies. This knowledge is important on surgical approaches, maybe avoiding iatrogenic lesions and negative outcomes.
Analysis of functional outcome of single and double level lumbar discectomy
Authors: Gupta Surendra , Singh Deepak Kumar , Chhabra Anuj , Kaif Mohd , Yadav Kuldeep , Singh Rakesh Kumar
Published: April 2022

Introduction:  Functional improvement in lumbar PIVD patients can be assessed either objectively like improvement in SLRT, relief in pain, etc or subjectively using different types of scales. In our study, we have used Revised Oswestry Disability Index (RODI) score, Ronald–Morris disability questionnaire (RDQ), The Back Bournemouth Questionnaire (BQ) to analyse functional outcome in single and double level lumbar PIVD patients pre-operatively and post-operatively.
Method:  It is a prospective study including 80 patients of lumbar PIVD who failed to respond to conservative treatment.  Patients were clinically evaluated and disability scales viz- RODI, RDQ & BQ were recorded. After lumber discectomy, patients were again assessed and scored as per disability scales at 1 month, 6 months and 1 year postoperatively.
Result:  RODI, RDQ and BQ scores were calculated at pre-operatively and post-operatively 1, 6 and 12 months and statistically analysed. The mean RODI scores at pre-operative and postoperative 1, 6, and 12 months were 72, 18, 10, and 6 respectively. The mean RDQ scores at pre-operative and postoperative 1, 6, and 12 months were 15, 5, 3, and 2 respectively.  Similarly, the mean BQ scores at pre-operative and postoperative 1, 6, and 12 months were 51, 12, 8, and 4 respectively.  Statistically, significant improvement was seen in mean scores of all 3 functional scales and maximum changes were observed after 1 month. Statistically, significant improvements were observed in 54 out of 62 patients (87%). Three questions of BQ related to the patient social and family activities, anxiety and depression were separately compared pre and post-operatively and they showed a statistically significant improvement.
Conclusion: Overall 87% of patients had a significant improvement in functional assessment using RODI, RDQ and BQ scales. On comparing single and double level discectomy patients, the functional improvement was similar in follow up of one year. Social and family activities (SFA), depression and anxiety of the patients improved significantly over 1 year.
Essentials of cerebral fat embolism syndrome
Authors: Lozada Marintez Ivan David , Ortega-Sierra Michael Gregorio , Zambrano-Arenas Maria Daniela Del Pilar , Páez-Escallón Natalia , Perea-Martinez Darwin Gabriel , Caldera-Arrautt Yuly Sofia , Solis-Bazza Kevin , Betancourt-Cundar Duvan Alexander , Gonzalez-Garces Hernando Jose , Manríque-Gualdron Andrés Mauricio , Zaghab-Zgieb Feraz Fady , Moscote-Salazar Luis Rafael
Published: April 2022

Fat embolism syndrome typically appears after an asymptomatic period of 24 to 72 hours and is typically manifested by the clinical triad of respiratory failure, neurological manifestations and petechiae, together with analytical alterations such as anaemia and thrombopenia. Respiratory distress is the most common symptom. Cerebral fat embolism is an incomplete form of fat embolism, which does not meet all the diagnostic criteria; in fact, it may appear without the presence of respiratory failure; Therefore, its early diagnosis is a challenge in the trauma patient
A rare occurrence of primary basal ganglia germinoma in an adult patient
Authors: Abdulla Ebtesam , Luther Harleen , Shah Tejal , Chandran Nisha
Published: April 2022

Background: Basal ganglia germinomas (BGGs) represent a diagnostic and management neurosurgical dilemma. Because of the rarity of these tumors in adults, the management strategies are not well defined.  
Case description: A 24-year-old man was presented with progressive left-sided hemiparesis. Cranial computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated a heterogeneous lesion with few microcystic nodules, seen involving the right basal ganglia with calcification. A stereotactic brain biopsy (SBB) was obtained. Histopathology revealed BGG. The patient received whole-brain radiation therapy (WBRT) and reported marked improvement in symptoms with no recurrence during a follow-up period of four years.
Conclusion: BGG should be considered a part of the differential diagnosis in young adults presented with hemiparesis and a heterogeneous lesion in the basal ganglia. Standard recommendations for the management of such rare lesions in adults are needed.
A case of sellar epidermoid tumour with haemorrhage
Authors: Kumar A. Ajaya , Gopal K. Geetha
Published: April 2022

Introduction: Intracranial epidermoid cysts are congenital inclusion tumours. Cerebellopontine angle and parasellar locations are the common locations. This is a report of an intrasellar epidermoid cyst with haemorrhage, which is rare.
Case report: A 70-year-old female presented with bifrontal headache, vertigo, and nasal discharge. Contrast-enhanced Magnetic resonance imaging[MRI] showed heterogeneously enhancing lesion in sella turcica. Internal hemorrhagic foci were seen. Computed tomography[CT] scan showed a slightly hyperdense tumour of sella. Transnasal transsphenoidal excision was done. Hemorrhagic and colloid material came out. Histopathological examination showed cyst lined by stratified squamous epithelium with keratohyalin granules and keratin flakes, suggestive of an epidermoid cyst.
Discussion: Usually epidermoid cyst is hypodense in CT scan. But hyperdensity can occur due to calcification of keratinized debris, increased protein content, and recurrent haemorrhage. Enhancement with gadolinium in MRI is mild and in cyst wall. Haemorrhage and enhancement are probably due to foreign body granulation tissue developing from leakage.
Epidemiological, demographic and clinical profile of traumatic brain injury patients
Authors: Sachan Abhijeet Singh , Sachan Prakrati , Chandra Sateesh
Published: April 2022

Context: Traumatic brain injury is a major public health problem worldwide with increasing incidence and severity in developing countries. In  India, it becomes a huge burden on society with a lack of proper preventive measures, public awareness, traffic sense and pre-hospital care. Therefore we studied the epidemiological profile and factors predicting outcome.
Aims: To study the epidemiological, demographic profile of  TBI  patients to help to improve the healthcare facilities.
Setting and design: It is an observational prospective study.
Methods and materials: Overall  2134 patients with TBI  were enrolled. The data was collected according to the predesigned proforma. The demographic, epidemiological, clinical variables were analysed to determine the current trends and outcomes.
Result: The male: female ratio was  2.21:1  with most cases from the age group of 21-30 years ( 29.42%). RTA  was the mode of injury in 64.48% of cases. Overall mortality was 10.91%. Overall descriptive data was suggestive of poor outcome in old patients, referred cases, acute SDH and brainstem lesions, hypoxic and hypotensive patients, associated injuries, pre-existing disease and with higher Rotterdam and ISS scores.
Conclusion: The outcome is dependent on factors like geographical, demographic, pre-hospital, and patient-related. With knowledge about the causes, patterns, and distribution the prognosis of TBI patients can be improved.
Outcome of patients undergoing posterior spine fixation and decompression for posttraumatic thoracolumbar spine fractures and the factors predicting it
Authors: Jose Geo Paul K. , Abraham Tinu Ravi , Balakrishnan P.K. , Irphan Muhammed P.S. , Haris T.P. , Prakashbhai Vala Parth
Published: April 2022

Background: Posterior spine fixation and decompression for thoracic and lumbar spine fractures have the advantage of stabilization of the fracture, decompression of neural canal, early mobilization and rehabilitation of the patient. The study aimed to find out the postoperative outcome and complications following posterior spine surgery and the factors affecting the outcome.

Methods: A retrospective study was carried out among 44 patients who underwent posterior spine decompression and fusion for thoracic and lumbar spine fracture. The data regarding patient presenting symptoms, comorbidity, associated injuries and imaging finding in CT and MRI were collected. The postoperative outcome of patients after surgery was assessed using ASIA impairment scale, KPS, VAS scale for pain are noted at the preoperative and postoperative period. Other factors like improvement of bowel and bladder symptoms, back stiffness and return to the job after surgery were also found out.

Results: There was a significant improvement in ASIA impairment scale (mean =0.74 grade), KPS score (mean = 40) and VAS pain scale (mean = 6.7) at 6 months follow up after surgery. Improvement in ASIA impairment scale was more in the patient with severe canal compromise (mean = 1.62 grade), patients with translational/ distraction injuries (mean= 1.01grade) and patients with paraparesis (mean=1.06). Only one-third of patients with bowel and bladder involvement improved after surgery. Around 56.8% of patients were able to return to jobs at 6 months follow up. Patients who were paraplegic at the initial presentation were mostly not able to return to jobs. The most common reported complication in the study was intraoperative pedicle breakage.

Conclusion: Decompression of the spinal cord plus posterior spine fixation is a safe, reliable and effective method in the management of thoracic and lumbar fractures with significant improvement in outcome in terms of motor power, pain and quality of life.
Basic considerations on growth hormone deficiency in traumatic brain injury
Authors: Lozada-Martinez Ivan David , Ortega-Sierra Michael Gregorio , Daza-Vega María Milagros , Cárdenas-Hormiga Leidy Natalia , Contreras-Saldarriaga Jorge Eduardo , Garcia-Moron Carlos Eduardo , Serna-Trejos Juan Santiago , Nuñez-Gamez Jorge Alberto , Gómez-Murillo Daniela , Rosero-Burgos Mary Elena , Moscote-Salazar Luis Rafael
Published: April 2022

Growth hormone is responsible for stimulating the growth and differentiation of cells of various tissues and cell types contribute to protein synthesis and the mobilization of fatty acids. At the nervous system level, it stimulates the regeneration of neurons, astrocytes, endothelial cells, oligodendrocytes, and even neuronal myelination. Traumatic brain injuries can alter the secretion of this hormone, due to the deformation of brain tissue and the alteration of neurometabolism by the subsequent ischemia. Knowing the basic aspects of pituitary disorders in this type of patient allows early identification and management to avoid complications
Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions
Authors: Clark Alec , Barpujari Arnav , Lucke-Wold Brandon , Porche Ken , Laurent Dimitri , Koch Matthew , Decker Matthew
Published: April 2022

Background: Cerebral amyloid angiopathy (CAA) has classically been described as a disease of the elderly. Genetic predisposition has been linked to the APOE e3/e3 allele. Evidence suggests that brain insult in the form of injury, prior surgical intervention, or radiation can exacerbate the clearance of toxic proteins in patients susceptible to CAA.
Case: We describe a unique case of CAA in a 30-year-old male who had prior surgical interventions for spina bifida, Chiari malformation, and hydrocephalus as a child.
Conclusions: The case is used to teach important components regarding diagnosis, clinical suspicion, and highlight the need for further investigation regarding the emerging role of the glymphatic system and its role in clinical pathology.
Tumefactive multiple sclerosis
Authors: Ortega-Sierra Michael Gregorio , Delgado-Marrugo Raul David , Campo-Bedoya Cristian Camilo , Marín-Pérez Geraldine , Gómez-Caballero Rhonald , Hernández-Nieto Bryan D. , Gutiérrez-Castillo Gabriel Fernando , Bello-Cordero John Fredys , Torres-Báez Mónica Alejandra , Ramirez-Morales Rafael Ricardo , Lozada-Martinez Ivan David , Moscote-Salazar Luis Rafael
Published: April 2022

Tumefactive multiple sclerosis is a rare variant of multiple sclerosis, characterized by the presence of brain lesions that may be solitary or multiple. Considering that these lesions have a pseudotumoral appearance, it is a challenge to differentiate them from central nervous system neoplasms through neuroimaging. Many cases are associated with the administration of monoclonal antibodies, and due to an increase in the incidence of cancer globally, it is expected that secondary to chemotherapeutic treatments, more and more cases may appear. Taking into account the above, the objective of this review is to review aspects of usefulness in clinical practice, on the diagnosis and approach of this pathological condition
Crescimento e qualidade de mudas de Myrocarpus frondosus Allemão em substrato alternativo
Authors: Da Silva Matheus Roberto , Machado Araujo Maristela , Carpenedo Aimi Suelen , Fermino Maria Helena , Mieth Patrícia , Scheuer Marina
Published: April 2022

A utilização de resíduos agroindustriais como componente de substrato pode ser uma alternativa viável de destinação, no entanto, ainda são necessários estudos com relação as proporções adequadas, garantindo a qualidade morfofisiológica das mudas produzidas no viveiro. Assim, o objetivo da pesquisa foi avaliar o uso do caroço de pêssego triturado e turfa marrom como substratos na produção de mudas de Myrocarpus frondosus em viveiro. Para a produção das mudas, foram utilizadas diferentes proporções (volume:volume) de caroço de pêssego triturado (C) e turfa marrom (T) (S1 - C100%; S2 - C80%:T20%; S3 - C60%:T40%; S4 - C40%:T60%; S5 - C20%:T80%; e S6 - T100%). O delineamento utilizado foi o inteiramente casualizado, com seis tratamentos e quatro repetições, nas 24 unidades amostrais, foram avaliadas as 12 mudas centrais, totalizando 48 mudas por tratamento. Avaliaram-se as 12 mudas centrais, totalizando 48 mudas por tratamento. Os atributos morfológicos avaliados foram: altura (H), diâmetro do coleto (DC), relação H/DC, matéria seca da parte aérea (MSPA), matéria seca radicular (MSR), matéria seca total (MST), área foliar (AF), volume radicular (VR) e Índice de Qualidade de Dickson (IQD). O caroço de pêssego triturado como substrato influenciou negativamente o crescimento das mudas. O tratamento utilizando 100% de turfa demonstrou superioridade para o desenvolvimento de mudas de Myrocarpus frondosus, constatando-se que mesmo sob proporções reduzidas de caroço de pêssego (20%), as plantas apresentam expressivo decréscimo (≥16%) dos atributos utilizados como indicadores.
Timber housing economy in Brazil: 2013 to 2022 scenarios and crises
Authors: Almeida De Araujo Victor , Souza Vasconcelos Juliano
Published: April 2022

Timber housing sector has several features and is essential for civil construction and forestry chains. In Brazil, the economy related to timber housing is still an unprecedented topic. Thus, the paper aimed to estimate scenarios to delimit the annual volume of this sector. Three years were studied from rare data available in the literature. From these national outcomes, projections for next years were developed. Multiple case approaches composed the literature-based methodology. As a result, the sector endured distinct internal and external economic instabilities, whose associated factors compiled political and sanitary crises, specially, with negative influences. The economy of timber housing reached an average about 500 million Dollars in 2014, being halved in 2015 due to the government crisis marked by the impeachment of the Brazilian president. From 2016 to 2019, small improvements were verified for this sector. In 2020, this favorable scenario was stagnated by the global Covid-19 pandemic. After 2021, a sectoral recovery is forecast based on positive expectations on the Brazilian economy. The two-year period of domestic presidential impeachment was more economically catastrophic than the current three-year phase of sanitary pandemic with global implications. From our economic forecasts, it was possible to attest that the Brazilian sector of timber houses is economically perceptible.
The relationship of laboratory parameters and rates with prognosis and mortality in COVID-19 infection
Authors: ERGENÇ Hasan , ERTÜRK Zeynep , TÖR İbrahim Hakkı , ARAÇ Songül , USANMAZ Mustafa , KARACAER Cengiz , KAYA Gülsüm
Published: April 2022

Objective:In this study, to evaluate the clinical course and prognosis in COVID-19 patients, to evaluate the hematological and biochemical parameters at the time of admission to the hospital.

Methods:This retrospective study was performed in a multicenter study in April and October 2020. Demographic characteristics, clinical features, age, gender and length of stay of patients who exitus (EX) and were discharged due to COVID-19 were examined.

Results:Of the patients (n:180) included in the study, 89 were female and 91 were male. There was a significant difference between the patients who were discharged from the hospital and died gender and complaints at the time of admission (p0.05). While the length of stay, platelet (PLT), mean corpuscular volume (MCV), serum C-reactive protein (CRP), albumin, lymphocyte, monocyte, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (LDH), ferritin, international normalized ratio, procalcitonin (PCT), troponin, and white blood cell counts are all increased in EX. There is a statistically significant difference in red blood cell distribution width (RDW) between EX and discharge patients (p0.05). While the RDW, monocyte/albumin, procalcitonin/albumin, CRP/albumin, LDH/albumin, and ürea/albumin ratios are increased in EX patients, the PCT/PLT and MPV/PLT ratios are increased in discharged patients.

Conclusion: In this study, we demonstrated that hematological and biochemical markers may be utilized as an early prognostic indicator for patients identified with COVID-19.
Diode Laser Excision of Focal Epithelial Hyperplasia (Heck’s Disease): A Case Report
Authors: Sarabadani Javad , Chiniforush Nasim , Yazdandoust Yasaman
Published: April 2022

Introduction: Focal epithelial hyperplasia (FEH), also known as Heck’s disease, is a human papilloma virus induced proliferation of epithelial cells, which causes asymptomatic lesions in the oral mucosa. Heck’s disease is more prevalent among children or in a family. Despite the self-limitation of lesions, they may progress or cause esthetical and functional discomforts. Hence, early diagnosis is necessary. Case Presentation: A middle-aged man with a peripheral multiple soft, elevated, sessile, smooth, lobulated surface and nodular lesions in his right buccal mucosa was referred. The dimensions of the lesions varied from 5 to 25 mm. Through clinical and histopathological examinations, Heck’s disease was diagnosed. The diode laser (wavelengths of 980 nm), 1-W power using continuous waves) was applied serially (in 2 sessions with a 1-week interval) for surgically removing the lesions. The patient was followed up for 6 months with no lesion recurrence, and gradual healing was observed. Conclusion: The laser is an effective treatment with no scar remaining after the procedure and brings satisfaction to patients.
Comparison of the Effectiveness of CO2 and Diode Lasers for Gingival Melanin Depigmentation: A Randomized Clinical Trial
Authors: Moeintaghavi Amir , Ahrari Farzaneh , Fallahrastegar Amir , Salehnia Asma
Published: April 2022

Introduction: Gingival hyperpigmentation is an esthetic concern for some individuals. This study compared the effectiveness of CO2 and diode lasers for gingival depigmentation. Methods: This randomized, split-mouth, clinical trial consisted of 12 patients with the chief complaint of hyperpigmented gingival areas. The upper right and left anterior segments and the mandibular anterior segment were randomly allocated to one of the treatment groups. The segments in group 1 underwent gingival depigmentation with a diode laser (810 nm) at 6 W and pulsed mode, whereas group 2 was ablated with a diode laser at 3 W and continuous mode. The removal of gingival pigments in group 3 was contemplated with a CO2 laser (10600 nm, 3 W, continuous mode). The operation chair time, bleeding during the procedure and post-operative pain were recorded. The gingival color and esthetic appearance were measured before the operation and at 1 week and 6 months later. Results: There was no significant difference in the bleeding scores, pain level, and color alteration values between the groups (P>0.05). The operation chair time was significantly shorter when the diode laser was applied at pulsed mode (P<0.05). The segments treated with the diode laser (pulsed or continuous mode) showed a higher esthetic appearance at the 6-month follow-up compared to those ablated with the CO2 laser (P<0.05). Conclusions: Higher esthetic appearance is expected when using the diode laser for gingival depigmentation compared to the CO2 laser. The application of the diode laser at pulsed mode could be recommended for gingival depigmentation, as it produced pleasing esthetic outcomes at reduced chair time.
Kontribusi Kecenderungan Pola Asuh Demokratis (Authoritative) dan Kecerdasan Emosi Terhadap Perilaku Asertif Pada Remaja Awal
Authors: Muliati Riska
Published: April 2022

Perilaku asertif akan menjadikan remaja awal memiliki daya tahan dalam menghadapi pengaruh negatif teman sebaya yang sangat menekan di sekitarnya. Penelitian ini bertujuan untuk menguji kontribusi kecenderungan pola asuh demokratis (authoritative) terhadap perilaku asertif pada remaja awal, kontribusi kecerdasan emosi terhadap perilaku asertif pada remaja awal, dan kontribusi kecenderungan pola asuh demokratis (authoritative) dan kecerdasan emosi terhadap perilaku asertif pada remaja awal. Metode yang digunakan adalah metode penelitian kuantitatif, dengan sampel sebanyak 210 orang remaja awal. Alat ukur yang digunakan pada penelitian ini diadaptasi dari skala Rathus Assertiveness Schedule (RAS) untuk mengukur perilaku asertif, Parenting Styles And Dimensions Questionnaire (PSDQ) untuk mengukur kecenderungan pola asuh demokratis, dan Indigenous Emotional Intelligence Scale untuk mengukur kecerdasan emosi. Teknik analisis yang digunakan adalah analisis regresi berganda dengan program SPSS. Hasil penelitian menunjukkan bahwa, terdapat kontribusi kecenderungan pola asuh demokratis (authoritative) terhadap perilaku asertif yang sangat signifikan pada remaja awal dengan nilai signifikansi sebesar 0,000 (p £ 0,05). Selanjutnya terdapat kontribusi kecerdasan emosi terhadap perilaku asertif yang sangat signifikan pada remaja awal dengan nilai signifikansi sebesar 0,000 (p £ 0,05). Sedangkan secara bersama-sama kecenderungan pola asuh demokratis (authoritative) dan kecerdasan emosi memiliki kontribusi terhadap perilaku asertif yang sangat signifikan pada remaja awal. Nilai signifikansi yang diperoleh sebesar 0,000 (p £ 0,05) dan nilai R Square = 0,125 yang berarti kontribusi pola asuh demokratis (authoritative) dan kecerdasan emosi terhadap perilaku asertif memiliki nilai sebesar 12,5 %, sedangkan sisannya dipengaruhi faktor lainnya diluar penelitian ini
Dukungan Sosial Keluarga dan Successful Aging pada Lanjut Usia
Authors: Azhari Putri Geizy , Yulianti Alma
Published: April 2022

Menjalani masa tua dengan bahagia dan sejahtera merupakan dambaan semua orang. Keadaan seperti ini hanya dapat dicapai oleh seseorang apabila orang tersebut merasa sehat secara fisik, mental dan sosial, merasa dibutuhkan, merasa dicintai, mempunyai harga diri serta dapat berpartisipasi dalam kehidupan. Setiap lansia harus mampu untuk menghadapi setiap perubahan-berubahan yang dialaminya untuk mencapai kesejahteraan dan kebahagiaan dihari senjanya, baik secara fisik, psikis dan sosialnya. Namun yang terjadi saat ini, tidak semua lansia dapat menjalani hari tuanya dengan bahagia dan sejahtera. Di Indonesia banyak ditemukan kasus lansia yang terlantar, lansia yang hidup di jalanan, lansia yang menjadi pemulung, lansia menjadi pengemis, serta ada pula lansia yang ditolak di panti sosial, sehingga hal tersebut menjadi sangat penting untuk diteliti lebih lanjut. Penelitian ini bertujuan untuk mengetahui hubungan dukungan sosial keluarga dengan successful aging pada lansia . Hipotesis yang diajukan adalah terdapat hubungan antara dukungan sosial keluarga dengan successful aging pada lanjut usia. Subjek dalam penelitian berjumlah 134 orang lansia yang berdomisili di Kec. Payakumbuh Utara Kota Payakumbuh. Data dikumpulkan dengan menggunakan skala dukungan sosial keluarga dan skala successful aging. Data penelitian dianalisis menggunakan teknik analisis Product Moment dari Pearson, yang menunjukan bahwa nilai koefisien korelasi dukungan sosial keluarga dengan successful aging adalah sebesar r = 0,631 dengan taraf signifikansi 0,000 (p<0,05). Hasil tersebut menunjukkan bahwa hipotesis dalam penelitian ini diterima, yaitu terdapat hubungan antara dukungan sosial keluarga dengan successful aging pada lanjut usia di Kec. Payakumbuh Utara Kota Payakumbuh.
A magyar fiatalok külföldi mobilitási tervei
Authors: Ruff Tamás
Published: April 2022

Magyarországon a nemzetközi vándorlással kapcsolatos kutatások a tudományban és a közéletben is nagy figyelmet kaptak az utóbbi tíz évben. A magyar 15- 29 éves fiatalok körében négyévente végzett nagymintás kutatás egyik fontos témája ez. Jelen tanulmány az utolsó adatfelvétel adatai alapján elemzi a fiatalok külföldi mobilitási terveit, összehasonlítva a korábbi adatokkal. Az adatfelvétel a 15-29 év közötti Magyarországon élő fiatalok 8000 fős reprezentatív mintáján készült, kérdezőbiztosok segítségével személyes megkeresés útján. A kutatás egyik legfőbb eredménye, hogy csökkent azoknak a fiataloknak az aránya, akik több évre vagy végleges letelepedés céljából külföldre szeretnének menni, valamint nőtt azoknak az aránya, akik azért nem szeretnének másik országba menni, mert itthon is boldogulnak.
Evaluasi Shear Wave Elastography, Fibroscan dan Kecepatan Aliran Vena Porta pada Pasien Non-Alcoholic Fatty Liver Disease
Authors: Gunawan Yullyftyani , Murtala Bachtiar , Asriyani Sri
Published: April 2022

Absract: This research aims to investigate the congruity between the Shear Wave Elastography, Fibroscan and changes in the portal vein flow velocity in non-alcoholic fatty liver disease patients.The research used was a cross-sectional study method. The research was conducted in the Radiology Section of Dr. Wahidin Sudirohusodo, Makassar from July to December 2020. The research populations were all patients with the clinical non-alcoholic fatty liver and fulfilled the inclusive and exclusive criteria. On the research samples, the Shear Wave Elastography and hepatic hemodynamics were examined using transabdominal ultrasonography, continued by determining the fibrosis degree based on Transient Elastography. Data were analyzed statistically through the Spearman’s correlation test, it was stated congruent if the P value was <0.05.The research involved 32 people, with the gender of 19 males (59.4%) with the range of 46-55 years old (31.3%) of the non-alcoholic fatty liver patients. Based on bivariate analysis, the research result indicates that there is no correlation between mean portal vein velocity and degree of fibrosis with Fibroscan and Shear Wave Elastography. The fibrosis degree with Shear Wave Elastography has a strong correlation (p = 0.001, r = 0.672) with the fibrosis degree based on the Fibroscan.Key words: Non-alcoholic fatty liver; Shear Wave Elastography; Transient Elastography Abstrak: Penelitian ini bertujuan mengetahui kesesuaian antara Shear Wave Elastography, Fibroscan dan perubahan kecepatan aliran vena porta pada pasien non-alcoholic fatty liver disease. Metode penelitian yang digunakan adalah kajian potong lintang. Penelitian dilaksanakan di Bagian Radiologi RS Dr. Wahidin Sudirohusodo, Makassar pada Juli sampai dengan Desember 2020. Populasi penelitian ini adalah semua pasien dengan klinis non-alcoholic fatty liver dan memenuhi kriteria inklusi dan ekslusi. Pada sampel penelitian ini dilakukan pemeriksaan Shear Wave Elastography dan hemodinamik hepar dengan ultrasonografi transabdominal, dilanjutkan dengan penentuan derajat fibrosis berdasarkan Transient Elastography. Data dianalisis secara statistik melalui uji korelasi Spearman dikatakan sesuai jika nilai P<0,05. Penelitian ini melibatkan sebanyak 32 orang, dengan jenis kelamin laki-laki 19 (59,4%) orang  dengan rentang usia terbanyak 46-55 (31,3%) tahun pada pasien non-alcoholic fatty liver. Hasil penelitian menunjukkan tidak didapatkan korelasi antara mean kecepatan vena porta dengan derajat fibrosis dengan Fibroscan dan Shear Wave Elastography. Pada derajat fibrosis dengan Shear Wave Elastography mempunyai korelasi kuat (p=0,001, r=0,672) dengan derajat fibrosis berdasarkan Fibroscan.Kata kunci: Non-alcoholic fatty liver; Shear Wave Elastography; Transient Elastography
Dando del ‘lei’, si dice vede o veda?
Authors: Cerruti Massimo
Published: April 2022

Alcuni lettori notano che dando del ‘lei’ a un interlocutore si usa spesso vede (es. vede, signor Rossi) e si chiedono se non sia più corretto veda (es. veda, signor Rossi).
Presentación
Authors: Resende Viviane , Oteíza Teresa
Published: April 2022

Editorial
Literatura ergódica y videojuegos: una invitación al desarrollo de herramientas y metodologías para el análisis de sus narrativas
Authors: Ponce Díaz Romano , Ávila González Iván
Published: April 2022

Utilizando como eje teórico a los Estudios Visuales y la influencia teórica de ALED en las investigaciones de Arte y Cultura en México, colocaremos nuestra mirada en las posibilidades del estudio del discurso de formas de narrativa digitales en las que el lector tiene la capacidad de alterar o construir el relato a partir de sus acciones directas no-triviales. Exploraremos la relación y diferenciación entre la literatura tradicional, la literatura electrónica y las narrativas ergódicas, y el papel de la transcodificación en la modificación de los valores constitutivos de las artes audiovisuales desde la perspectiva latinoamericana de los estudios del discurso. Considerando que la proliferación de la producción audiovisual acarrea una multiplicación exponencial de la polifonía cultural, lo que afirma la relevancia e importancia del análisis del discurso, especialmente el estudio de aquellas voces que no se encuentran adheridas a los centros de legitimación hegemónicos. Emitiremos una definición estabilizada de narrativa ergódica bajo el contexto de los videojuegos: Myst (Miller and Miller, 1993),

Spec Ops: The Line (Davis and Coulon, 2012), S.T.A.L.K.E.R.: Shadow of Chernobyl (Adams, 2007). Lo que nos permitirá enunciar en qué consisten las características particulares de los videojuegos como medio narrativo en relación a otras artes audiovisuales, y manifestar la necesidad de generar modelos particulares de análisis del discurso para estas modalidades narrativas.
Jóvenes mapuche: aprendiendo inglés y reflexionando sobre su identidad cultural. Una aproximación desde el Sistema de Valoración
Authors: Klenner Loebel Maura Paulina , Beltrán-Véliz Juan Carlos , Merino Dickinson María Eugenia
Published: April 2022

En Chile, se han creado políticas educativas para el fortalecimiento del aprendizaje del inglés, sin embargo, no se han realizado los mismos esfuerzos para la mantención de las lenguas originarias. Este estudio tiene por objetivo explorar cómo los estudiantes mapuche evalúan el hecho de aprender inglés como una asignatura del plan de estudios nacional, sin tener la posibilidad de acceder a educación formal en su lengua originaria. En este estudio cualitativo participaron 16 jóvenes mapuche. Los datos fueron recolectados mediante entrevistas en profundidad. El discurso de los estudiantes fue analizado mediante el Sistema de Valoración (Martin & White, 2005). Los resultados indican que los estudiantes valoran positivamente el idioma inglés como una herramienta comunicativa que les aportará a desenvolverse en su futuro laboral. Sin embargo, reconocen que la cultura y lengua mapuche no son valoradas de la misma forma por el sistema educativo que la cultura y lengua inglesas.
Las modulaciones del poder. Cercanía y poder en la consulta de medicina familiar y comunitaria
Authors: Madfes Irene
Published: April 2022

Los distintos contextos médico-ideológicos presentan diferentes posibilidades de espacios de negociación según el grado de admisión de la iniciativa del/ de la paciente y la aceptación del guión por éste/a propuesto. Las dimensiones de cercanía y poder, presentes en todas las consultas, gravitan diferentemente en la construcción de la interacción médico-paciente, primando ya la cercanía, ya el poder. Estudiar el funcionamiento de estas dimensiones en consultas médicas de la Medicina Familiar, ubicada en el paradigma biopsicosocial y centrada en los aspectos subjetivos y contextuales de las personas, podrá mostrar el manejo de las divergencias y cómo, gracias a esto, se intenta equilibrar la práctica del poder por la responsabilidad social cosa que no solo limita el poder del médico, sino que permite el empoderamiento del/de la paciente.
Drogas y exclusión social: análisis crítico del discurso de la Estrategia Nacional para la Prevención de Adicciones
Authors: Beltrán Velarde Daniel Francisco , Íñiguez-Rueda Lupicinio
Published: April 2022

El objetivo del presente artículo es comprender el discurso y los efectos de la Estrategia Nacional para la Prevención de Adicciones (ENPA), principal política pública en materia de drogas del actual gobierno mexicano (2018-2024). Para ello se analiza, por medio del análisis crítico del discurso, la fase comunicativa de la campaña en dos niveles: la construcción de representaciones de los actores, por un lado, y de los procesos que giran en torno al uso de drogas, por otro. Los resultados indican que la estrategia aborda al uso y a los procesos relacionados desde los lugares comunes del prohi-bicionismo, pero dicha representación va más allá de la creación de imágenes, pues constituye a la propia sociedad al reforzar una serie de relaciones sociales donde los usuarios son colocados en los márgenes de la sociedad.
Discursos da extrema-direita no Brasil
Authors: Piovezani Carlos
Published: April 2022

Usar a linguagem humana para calar adversários, transformados em inimigos, e incitar seus adeptos à violência são duas das principais propriedades da linguagem fascista. Neste artigo, pretendemos realizar uma breve exposição de certas semelhanças e diferenças entre o populismo e o fascismo, para, em seguida, apresentar algumas reflexões sobre a linguagem fascista, a partir de Victor Klemperer e de Jean-Pierre Faye, e para, finalmente, analisar alguns pronunciamentos e declarações de Jair Bolsonaro. Nossos principais propósitos consistem em problematizar uma distinção feita pelo historiador Federico Finchelstein entre populismo e fascismo e em sustentar a ideia de que vários discursos desse político brasileiro, produzidos ao longo de mais de três décadas de vida pública, materializam traços de uma linguagem neofascista. Para a execução do trabalho, empregaremos alguns postulados da Análise do discurso, além de nos valermos de certos princípios da Retórica.
औषधीय धूम्र के चिकित्सकीय प्रयोग : यज्ञ के सन्दर्भ में
Authors: Batham Lalima
Published: April 2022

प्राचीन काल से धार्मिक अनुष्ठानों में यज्ञ अथवा हवन हिंदू धर्म में शुद्धीकरण की एक पद्धति मानी गयी  है। औषधीय धूम्र  को यज्ञीय धूम्र के अंतर्गत माना जा सकता है। इस शोध लेख का उद्देश्य औषद्यीय धूम्र की विधि, समय, लक्षण, हानियां, लाभ और यज्ञ धूम्र से समानता का अध्ययन करना है। आयुर्वेद में औषधियों के धूम्र का सेवन (धूम्रपान) विभिन्न प्रकार की औषधियों का प्रयोग कर विभिन्न रोगों के उपचार के लिए किया जाता है।  जो औषधीय गुण धूम्र के माध्यम से नासिका द्वारा लेने पर सीधे हमारे रक्त में घुलकर शरीर पर प्रभाव डालते हैं। आयुर्वेद में औषधीय धूम्रपान की अलग अलग विधियां बताई गयी हैं। आयुर्वेद के औषधीय वाष्प को जिसे स्वेदन क्रिया कहा जाता है। इसमें भी शरीर के बाहर से विभिन्न औषधियों का प्रयोग कर विजातीय तत्वों को बाहर निकला जाता है। यज्ञ में, अथर्ववेद (3/11/2) में कहा गया है कि अगर किसी व्यक्ति की स्थिति मरने जैसी हो भी गयी हो, उसकी जीवनी शक्ति का ह्रास हो गया हो तो भी यज्ञ उसे मौत के मुँह से बचा लेता है और उसे सौ वर्षों तक जीवित रहने के लिए बलवान, स्फूर्तिवान कर देता है। यज्ञ औषधीय धूम्र से शारीरिक स्वास्थ्य, मानसिक  स्वास्थ्य और आध्यात्मिक स्वास्थ्य लाभ की भी प्राप्ति होती है।  इस प्रकार, आयुर्वेद विधियों को सूक्ष्मता की द्रष्टि से यज्ञोपचार प्रक्रिया के अंतर्गत समझा जाना चाहिए। यज्ञीय धूम्र और औषधीय धूम्र में समानता को समझते हुए इस अध्ययन के माध्यम से यह कहा जा सकता है की औषद्यीय धूम्रपान को यज्ञीय चिकित्सा के अंतर्गत ही समझा जाना चाहिए।

Yagya or Havan has been considered a method of purification in Hindu religion since ancient times in religious rituals. Herbal fumes can be considered similar to Yagya fumes. The purpose of this research article is to study the method, timing, symptoms, harms, benefits, and similarities of Yagya fumes with herbal fume. In Ayurveda, the fumes of herbal medicines (Dhoompana) are used for the treatment of various diseases by using different types of herbs. The medicinal properties of herbal fumes, when taken through the nostrils, directly dissolve in our blood and affect the body. Different methods of Dhoompana have been described in Ayurveda. The herbal vapor in Ayurveda treatment is called Swedana Kriya, in which the foreign elements are removed outside from the body by using various herbal vapors. Similarly, the physical health, mental health, and spiritual health benefits from Yagya fumes are also obtained. Regarding Yagya fumes, in Atharvaveda (3/11/2), it is said that even if a person's condition has become like death, his vitality has diminished, yet Yagya saves him from the mouth of death and makes him strong to live and invigorates for a hundred years. In this way, all these methods of Ayurveda should be understood from the point of view of the process of Yagya. The present paper through understanding the similarities between Yagya fumes and herbal fumes concluded that treatment of Herbal Dhoompana should be understood under Yagya Therapy.
Reproducibilidad, Replicación y Prácticas de Investigación Cuestionables en Estudios de Revistas Académicas Arbitradas en México y Guatemala
Authors: Aguilera Arévalo Humberto Emilio , Ramírez Contreras María Guadalupe
Published: April 2022

OBJETIVO: evaluar si los estudios publicados en revistas académicas arbitradas de recién creación en México y Guatemala se pueden reproducir. Asimismo, se pretendió evaluar si se hacen replicaciones de estudios. De igual forma, si están presentes prácticas de investigación cuestionables y sesgo de publicación. MÉTODO: en este estudio se usó un diseño cuantitativo, descriptivo y transversal. Se obtuvo una muestra de conveniencia de 20 estudios de México y 10 de Guatemala, uno por revista creada en el 2021. RESULTADOS: se encontró que ninguno de los estudios se puede reproducir. Asimismo, hay una ausencia de replicaciones en las investigaciones. Se descubrió que pocos estudios presentaban prácticas de investigación cuestionables. Asimismo, no se observó sesgo de publicación en las investigaciones. CONCLUSIÓN: se concluyó que la reproducibilidad y replicación de estudios no son populares en revistas académicas arbitradas de recién creación de este estudio. Despierta gran preocupación que los resultados no se puedan verificar. Asimismo, es preocupante que no haya replicación de estudios en revistas de recién creación. Estas problemáticas deben ser abordadas por los entes editoriales a la brevedad.
Effects of Magnesium Sulphate (MgSO4) Versus Fentanyl as an Adjuvant to Epidural Bupivacaine in Lower Abdominal Surgeries
Authors: Chowdhury Dr. Md. Nazmus Sakeb , Saha Dr. Panna Lal , Tusher Dr. Saiful Mahmud , Hossain Dr. MD. Emdad , Biswas Dr. Sushmita , Nasrin Dr. Sultana , Khanam Dr. Halima , Afrin Dr. Sazia , Ali Dr. Md Arman
Published: April 2022

Background: In modern anaesthesia practice, a number of agents are used as adjuncts with epidural local anesthetics to achieve good perioperative hemodynamic stability as well as prolong the postoperative analgesia period. Among the different adjuvants, Fentanyl and Magnesium sulphate shows the promising results. Objectives: To study the effects of Magnesium Sulphate (MgSO4) versus Fentanyl as an Adjuvant to single-shot Epidural Plain Bupivacaine in Lower Abdominal Surgeries. Methods: It is a randomized controlled trail study, carried out in the Department of Anaesthesia, Analgesia, Palliative & Intensive Care Medicine, Dhaka Medical College Hospital Dhaka. Study populations were patients of ASA Status I-II planned for lower abdominal surgery under single-shot epidural anaesthesia. Study populations were randomly allocated into one of the three groups, of 25 each- group C, M&F. Group C-Patients received plain bupivacaine 0.5% 20 ml. Group M - Patients plain bupivacaine 0.5%(19 ml)+500 mg magnesium sulphate (1ml) and group F received plain bupivacaine 0.5% (19 ml)+50μg Fentanyl (1ml). Data were processed and analyzed by SPSS version 22.0. Results: It was found that the onset of sensory block at T8 was faster in Group M and F (14.2±2.5 min & 13.8±2.2 min) than Group C (18.5±3.1 min). On comparison of the required time to achievement of sensory loss between groups, required time was 11-15 minutes in 12(48.0%) patients of Group-M, 15(60.0%) in group F versus 16-20 minutes in 12(48.0%) patients of Group-C. The result was significant (*p-value < 0.05). In this study duration of sensory block was longer in Group-M ˃Group-F˃ group C. Result was significant between groups (p<0.01). But the motor block was almost similar between groups. No statistically significant difference was seen in between groups. It was evident that intensity of pain was lower up to 6 hrs. After anaesthesia, following that pain increases and analgesic also required in all groups, comparatively ........