bluuebunny/crossref_metadata_2025 huggingface dataset:
Copper Chelation Therapy Attenuates Periodontitis Inflammation through the Cuproptosis/Autophagy/Lysosome Axis
Authors: Zhang Lujin , Tsai I-Chen , Ni Zihan , Chen Beichen , Zhang Shuaiyuan , Cai Luhui , Xu Qiong
Published: May 2024

Periodontitis development arises from the intricate interplay between bacterial biofilms and the host’s immune response, where macrophages serve pivotal roles in defense and tissue homeostasis. Here, we uncover the mitigative effect of copper chelator Tetrathiomolybdate (TTM) on periodontitis through inhibiting cuproptosis, a newly identified form of cell death which is dependent on copper. Our study reveals concurrent cuproptosis and a macrophage marker within murine models. In response to lipopolysaccharide (LPS) stimulation, macrophages exhibit elevated cuproptosis-associated markers, which are mitigated by the administration of TTM. TTM treatment enhances autophagosome expression and mitophagy-related gene expression, countering the LPS-induced inhibition of autophagy flux. TTM also attenuates the LPS-induced fusion of autophagosomes and lysosomes, the degradation of lysosomal acidic environments, lysosomal membrane permeability increase, and cathepsin B secretion. In mice with periodontitis, TTM reduces cuproptosis, enhances autophagy flux, and decreases Ctsb levels. Our findings underscore the crucial role of copper-chelating agent TTM in regulating the cuproptosis/mitophagy/lysosome pathway during periodontitis inflammation, suggesting TTM as a promising approach to alleviate macrophage dysfunction. Modulating cuproptosis through TTM treatment holds potential for periodontitis intervention.
Molecular Classification of Endometrial Cancer and Its Impact on Therapy Selection
Authors: Galant Natalia , Krawczyk Paweł , Monist Marta , Obara Adrian , Gajek Łukasz , Grenda Anna , Nicoś Marcin , Kalinka Ewa , Milanowski Janusz
Published: May 2024

Endometrial cancer (EC) accounts for 90% of uterine cancer cases. It is considered not only one of the most common gynecological malignancies but also one of the most frequent cancers among women overall. Nowadays, the differentiation of EC subtypes is based on immunohistochemistry and molecular techniques. It is considered that patients’ prognosis and the implementation of the appropriate treatment depend on the cancer subtype. Patients with pathogenic variants in POLE have the most favorable outcome, while those with abnormal p53 protein have the poorest. Therefore, in patients with POLE mutation, the de-escalation of postoperative treatment may be considered, and patients with abnormal p53 protein should be subjected to intensive adjuvant therapy. Patients with a DNA mismatch repair (dMMR) deficiency are classified in the intermediate prognosis group as EC patients without a specific molecular profile. Immunotherapy has been recognized as an effective treatment method in patients with advanced or recurrent EC with a mismatch deficiency. Thus, different adjuvant therapy approaches, including targeted therapy and immunotherapy, are being proposed depending on the EC subtype, and international guidelines, such as those published by ESMO and ESGO/ESTRO/ESP, include recommendations for performing the molecular classification of all EC cases. The decision about adjuvant therapy selection has to be based not only on clinical data and histological type and stage of cancer, but, following international recommendations, has to include EC molecular subtyping. This review describes how molecular classification could support more optimal therapeutic management in endometrial cancer patients.
Effects of Endocrine Interventions Targeting ERα or PR on Breast Cancer Risk in the General Population and Carriers of BRCA1/2 Pathogenic Variants
Authors: Huber Deborah , Hatzipanagiotou Maria , Schüler-Toprak Susanne , Ortmann Olaf , Treeck Oliver
Published: May 2024

There is evidence suggesting that endocrine interventions such as hormone replacement therapy and hormonal contraception can increase breast cancer (BC) risk. Sexual steroid hormones like estrogens have long been known for their adverse effects on BC development and progression via binding to estrogen receptor (ER) α. Thus, in recent years, endocrine interventions that include estrogens have been discussed more and more critically, and their impact on different BC subgroups has increasingly gained interest. Carriers of pathogenic variants in BRCA1/2 genes are known to have a high risk of developing BC and ovarian cancer. However, there remain open questions to what extent endocrine interventions targeting ERα or the progesterone receptor further increase cancer risk in this subgroup. This review article aims to provide an overview and update on the effects of endocrine interventions on breast cancer risk in the general population in comparison to BRCA1/2 mutation carriers. Finally, future directions of research are addressed, to further improve the understanding of the effects of endocrine interventions on high-risk pathogenic variant carriers.
Arabidopsis Transcriptomics Reveals the Role of Lipoxygenase2 (AtLOX2) in Wound-Induced Responses
Authors: Kaur Diljot , Schedl Andreas , Lafleur Christine , Martinez Henao Julian , van Dam Nicole M. , Rivoal Jean , Bede Jacqueline C.
Published: May 2024

In wounded Arabidopsis thaliana leaves, four 13S-lipoxygenases (AtLOX2, AtLOX3, AtLOX4, AtLOX6) act in a hierarchical manner to contribute to the jasmonate burst. This leads to defense responses with LOX2 playing an important role in plant resistance against caterpillar herb-ivory. In this study, we sought to characterize the impact of AtLOX2 on wound-induced phytohormonal and transcriptional responses to foliar mechanical damage using wildtype (WT) and lox2 mutant plants. Compared with WT, the lox2 mutant had higher constitutive levels of the phytohormone salicylic acid (SA) and enhanced expression of SA-responsive genes. This suggests that AtLOX2 may be involved in the biosynthesis of jasmonates that are involved in the antagonism of SA biosynthesis. As expected, the jasmonate burst in response to wounding was dampened in lox2 plants. Generally, 1 h after wounding, genes linked to jasmonate biosynthesis, jasmonate signaling attenuation and abscisic acid-responsive genes, which are primarily involved in wound sealing and healing, were differentially regulated between WT and lox2 mutants. Twelve h after wounding, WT plants showed stronger expression of genes associated with plant protection against insect herbivory. This study highlights the dynamic nature of jasmonate-responsive gene expression and the contribution of AtLOX2 to this pathway and plant resistance against insects.
Pathological Changes and Metabolic Adaptation in the Myocardium of Rats in Response to Chronic Variable Mild Stress
Authors: Ostrowska-Leśko Marta , Herbet Mariola , Pawłowski Kamil , Korga-Plewko Agnieszka , Poleszak Ewa , Dudka Jarosław
Published: May 2024

Chronic variable mild stress (CVS) in rats is a well-established paradigm for inducing depressive-like behaviors and has been utilized extensively to explore potential therapeutic interventions for depression. While the behavioral and neurobiological effects of CVS have been extensively studied, its impact on myocardial function remains largely unexplored. To induce the CVS model, rats were exposed to various stressors over 40 days. Behavioral assessments confirmed depressive-like behavior. Biochemical analyses revealed alterations in myocardial metabolism, including changes in NAD+ and NADP+, and NADPH concentrations. Free amino acid analysis indicated disturbances in myocardial amino acid metabolism. Evaluation of oxidative DNA damage demonstrated an increased number of abasic sites in the DNA of rats exposed to CVS. Molecular analysis showed significant changes in gene expression associated with glucose metabolism, oxidative stress, and cardiac remodeling pathways. Histological staining revealed minor morphological changes in the myocardium of CVS-exposed rats, including increased acidophilicity of cells, collagen deposition surrounding blood vessels, and glycogen accumulation. This study provides novel insights into the impact of chronic stress on myocardial function and metabolism, highlighting potential mechanisms linking depression and cardiovascular diseases. Understanding these mechanisms may aid in the development of targeted therapeutic strategies to mitigate the adverse cardiovascular effects of depression.
Prenatal Hypoxia Triggers a Glucocorticoid-Associated Depressive-like Phenotype in Adult Rats, Accompanied by Reduced Anxiety in Response to Stress
Authors: Stratilov Viktor , Potapova Sofiya , Safarova Diana , Tyulkova Ekaterina , Vetrovoy Oleg
Published: May 2024

Fetal hypoxia and maternal stress frequently culminate in neuropsychiatric afflictions in life. To replicate this condition, we employed a model of prenatal severe hypoxia (PSH) during days 14–16 of rat gestation. Subsequently, both control and PSH rats at 3 months old were subjected to episodes of inescapable stress to induce learned helplessness (LH). The results of the open field test revealed an inclination towards depressive-like behavior in PSH rats. Following LH episodes, control (but not PSH) rats displayed significant anxiety. LH induced an increase in glucocorticoid receptor (GR) levels in extrahypothalamic brain structures, with enhanced nuclear translocation in the hippocampus (HPC) observed both in control and PSH rats. However, only control rats showed an increase in GR nuclear translocation in the amygdala (AMG). The decreased GR levels in the HPC of PSH rats correlated with elevated levels of hypothalamic corticotropin-releasing hormone (CRH) compared with the controls. However, LH resulted in a reduction of the CRH levels in PSH rats, aligning them with those of control rats, without affecting the latter. This study presents evidence that PSH leads to depressive-like behavior in rats, associated with alterations in the glucocorticoid system. Notably, these impairments also contribute to increased resistance to severe stressors.
Substance P’s Impact on Chronic Pain and Psychiatric Conditions—A Narrative Review
Authors: Humes Charles , Sic Aleksandar , Knezevic Nebojsa Nick
Published: May 2024

Substance P (SP) plays a crucial role in pain modulation, with significant implications for major depressive disorder (MDD), anxiety disorders, and post-traumatic stress disorder (PTSD). Elevated SP levels are linked to heightened pain sensitivity and various psychiatric conditions, spurring interest in potential therapeutic interventions. In chronic pain, commonly associated with MDD and anxiety disorders, SP emerges as a key mediator in pain and emotional regulation. This review examines SP’s impact on pain perception and its contributions to MDD, anxiety disorders, and PTSD. The association of SP with increased pain sensitivity and chronic pain conditions underscores its importance in pain modulation. Additionally, SP influences the pathophysiology of MDD, anxiety disorders, and PTSD, highlighting its potential as a therapeutic target. Understanding SP’s diverse effects provides valuable insights into the mechanisms underlying these psychiatric disorders and their treatment. Further research is essential to explore SP modulation in psychiatric disorders and develop more effective treatment strategies.
A Comprehensive Analytical Review of Polyphenols: Evaluating Neuroprotection in Alzheimer’s Disease
Authors: Vicente-Zurdo David , Gómez-Mejía Esther , Rosales-Conrado Noelia , León-González María Eugenia
Published: May 2024

Alzheimer’s Disease (AD), a prevalent neurodegenerative disorder, is the primary cause of dementia. Despite significant advancements in neuroscience, a definitive cure or treatment for this debilitating disease remains elusive. A notable characteristic of AD is oxidative stress, which has been identified as a potential therapeutic target. Polyphenols, secondary metabolites of plant origin, have attracted attention due to their potent antioxidant properties. Epidemiological studies suggest a correlation between the consumption of polyphenol-rich foods and the prevention of chronic diseases, including neurodegenerative disorders, which underscores the potential of polyphenols as a therapeutic strategy in AD management. Hence, this comprehensive review focuses on the diverse roles of polyphenols in AD, with a particular emphasis on neuroprotective potential. Scopus, ScienceDirect, and Google Scholar were used as leading databases for study selection, from 2018 to late March 2024. Analytical chemistry serves as a crucial tool for characterizing polyphenols, with a nuanced exploration of their extraction methods from various sources, often employing chemometric techniques for a holistic interpretation of the advances in this field. Moreover, this review examines current in vitro and in vivo research, aiming to enhance the understanding of polyphenols’ role in AD, and providing valuable insights for forthcoming approaches in this context.
Spatiotemporal Distribution Characteristics and Influencing Factors of Dissolved Potentially Toxic Elements along Guangdong Coastal Water, South China
Authors: Kang Gelin , Chen Hanbao , Hu Chuanqi , Wang Fangzheng , Qi Zuoda
Published: May 2024

In this study, five potentially toxic elements (PTEs) (Hg, Pb, As, Zn, and Cu) and five physicochemical factors (pH, dissolved oxygen, salinity, chlorophyll a, and chemical oxygen demand) relating to surface seawater were measured along the coast of Guangdong Province (GD), China, during three seasons in 2019. Comprehensive analyses were conducted to explore the distribution characteristics, pollution degrees, and influencing factors of PTE. The results showed that the concentrations of PTE varied spatially and seasonally due to these elements’ complex sources and behaviors. Pb was the most abundant toxic element, reaching considerable contamination levels. Overall, the average pollution degrees of Cu, As, and Zn were higher around the east coast of GD, while Hg and Pb levels were higher in the west coast region of GD. The correlation analysis showed that the variation of different physicochemical parameters had different degrees of influence on PTE transport and transformation. This study can help environmental managers gain deeper insight into the influence of complex factors on PTE and improve the efficiency of pollution control in this significant subtropical coastal area.
Penetration Characteristics of Mono-Column Composite Bucket Foundation for Offshore Wind Turbines
Authors: Xiao Jiandong , Gu Xiaoqiang , Lin Yifeng , Cheng Haifeng , Qi Xin , Zhang Puyang , Wang Shuyang
Published: May 2024

To address the issue of seepage and soil plugging during the sinking of mono-column composite bucket foundations (MCCBFs), experiments were conducted on the installation of foundations under a variety of complex geological conditions. The effect of negative pressure sinking mode on the foundation’s seepage field was analyzed, the formation mechanism of soil plugging in sand was explained, and an efficient method for calculating the height of soil plugging was proposed in conjunction with these investigations. The findings demonstrate that the finite element method simulation of the soil’s seepage field is the most accurate, that the pumping volume of the foundation during sinking through is high, that the formation of the soil plug height is high, and that clear depressions can be seen on the foundation manifold’s exterior. The equation presented in this study makes it easier to forecast the height of a foundation plug and can offer direction for engineering design.
High-Accuracy and Fast Calculation Framework for Berthing Collision Force of Docks Based on Surrogate Models
Authors: Zeng Haikun , Zhu Ruihu , Wang Qiming , Zou Junjie
Published: May 2024

The accurate prediction of the collision force magnitude resulting from ship berthing on docks is crucial for the rationality and safety of dock structural design. This paper presents a novel framework for the calculation of berthing collision force for ships (CBCF), which integrates field data, finite element models, and surrogate models. Based on field data and finite element analysis, the framework constructs and compares four surrogate models with low sample requirements, ultimately selecting the optimal surrogate model for predicting collision force. Furthermore, a sensitivity analysis of the parameters is conducted based on the selected model, followed by a comparison with the various methods used for collision force prediction. The results illustrate the effectiveness of the proposed framework in replacing finite element models for the rapid and accurate prediction of collision force. Comparison with existing methods also underscores the advantages of the proposed framework, including low sample requirements, high calculation accuracy, and exceptional efficiency. In summary, this study not only introduces a novel and precise surrogate model framework for the swift prediction of berthing collision force, but it also offers valuable insights into the prevention of ship collision with wharf accidents and facilitates the rational and safe design of wharf structures.
Correlation between Genomic Variants and Worldwide COVID-19 Epidemiology
Authors: Costa Ana Caroline Alves da , Albarello Gellen Laura Patrícia , Fernandes Marianne Rodrigues , Coelho Rita de Cássia Calderaro , Monte Natasha , Moraes Francisco Cezar Aquino de , Calderaro Maria Clara Leite , Freitas Lilian Marques de , Matos Juliana Aires , Fernandes Thamara Fernanda da Silva , Aguiar Kaio Evandro Cardoso , Vinagre Lui Wallacy Morikawa Souza , dos Santos Sidney Emanuel Batista , dos Santos Ney Pereira Carneiro
Published: May 2024

COVID-19 is a systemic disease caused by the etiologic agent SARS-CoV-2, first reported in Hubei Province in Wuhan, China, in late 2019. The SARS-CoV-2 virus has evolved over time with distinct transmissibility subvariants from ancestral lineages. The clinical manifestations of the disease vary according to their severity and can range from asymptomatic to severe. Due to the rapid evolution to a pandemic, epidemiological studies have become essential to understand and effectively combat COVID-19, as the incidence and mortality of this disease vary between territories and populations. This study correlated epidemiological data on the incidence and mortality of COVID-19 with frequencies of important SNPs in GWAS studies associated with the susceptibility and mortality of this disease in different populations. Our results indicated significant correlations for 11 genetic variants (rs117169628, rs2547438, rs2271616, rs12610495, rs12046291, rs35705950, rs2176724, rs10774671, rs1073165, rs4804803 and rs7528026). Of these 11 variants, 7 (rs12046291, rs117169628, rs1073165, rs2547438, rs2271616, rs12610495 and rs35705950) were positively correlated with the incidence rate, these variants were more frequent in EUR populations, suggesting that this population is more susceptible to COVID-19. The rs2176724 variant was inversely related to incidence rates; therefore, the higher the frequency of the allele is, the lower the incidence rate. This variant was more frequent in the AFR population, which suggests a protective factor against SARS-CoV-2 infection in this population. The variants rs10774671, rs4804803, and rs7528026 showed a significant relationship with mortality rates. SNPs rs10774671 and rs4804803 were inversely related to mortality rates and are more frequently present in the AFR population. The rs7528026 variant, which is more frequent in the AMR population, was positively related to mortality rates. The study has the potential to identify and correlate the genetic profile with epidemiological data, identify populations that are more susceptible to severe forms of COVID-19, and relate them to incidence and mortality.
Vapor Pressure and Enthalpy of Vaporization of Guanidinium Methanesulfonate as a Phase Change Material for Thermal Energy Storage
Authors: Bi Wenrong , Liu Shijie , Rong Xing , Ma Guangjun , Luo Jiangshui
Published: May 2024

This paper reports the vapor pressure and enthalpy of vaporization for a promising phase change material (PCM) guanidinium methanesulfonate ([Gdm][OMs]), which is a typical guanidinium organomonosulfonate that displays a lamellar crystalline architecture. [Gdm][OMs] was purified by recrystallization. The elemental analysis and infrared spectrum of [Gdm][OMs] confirmed the purity and composition. Differential scanning calorimetry (DSC) also confirmed its high purity and showed a sharp and symmetrical endothermic melting peak with a melting point (Tm) of 207.6 °C and a specific latent heat of fusion of 183.0 J g−1. Thermogravimetric analysis (TGA) reveals its thermal stability over a wide temperature range, and yet three thermal events at higher temperatures of 351 °C, 447 °C, and 649 °C were associated with vaporization or decomposition. The vapor pressure was measured using the isothermogravimetric method from 220 °C to 300 °C. The Antoine equation was used to describe the temperature dependence of its vapor pressure, and the substance-dependent Antoine constants were obtained by non-linear regression. The enthalpy of vaporization (ΔvapH) was derived from the linear regression of the slopes associated with the linear temperature dependence of the rate of weight loss per unit area of vaporization. Hence, the temperature dependence of vapor pressures ln Pvap (Pa) = 10.99 − 344.58/(T (K) − 493.64) over the temperature range from 493.15 K to 573.15 K and the enthalpy of vaporization ΔvapH = 157.10 ± 20.10 kJ mol−1 at the arithmetic mean temperature of 240 °C were obtained from isothermogravimetric measurements using the Antoine equation and the Clausius–Clapeyron equation, respectively. The flammability test indicates that [Gdm][OMs] is non-flammable. Hence, [Gdm][OMs] enjoys very low volatility, high enthalpy of vaporization, and non-flammability in addition to its known advantages. This work thus offers data support, methodologies, and insights for the application of [Gdm][OMs] and other organic salts as PCMs in thermal energy storage and beyond.
Exploring Oat Husks as Aggregates in Limestone-Based Composites: Effects of Surface Treatments and Binder Selection on Mechanical Performance
Authors: Bonifacio Alysson Larsen , Archbold Paul
Published: May 2024

The viability of incorporating agricultural by-products, such as oat husks, not yet explored in limestone-based composites, as more sustainable alternatives for use as novel aggregates may be improved through the adoption of well-known valorisation strategies applied to other plant-based resources. In this context, this work innovates by assessing how treatments on oat husk surfaces and the choice of limestone-based binders impact the mechanical performance of composites. The strategy adopted to achieve these objectives, in addition to carrying out the physical and geometric characterisation of the husks, consists of treating the husks’ surface using washing cycles in water, cement/pozzolan binder, and linseed oil. Furthermore, matrices combining cement, calcium hydroxide Ca(OH)2, and microsilica (SiO2) were used. In conclusion, even though the effects of different binder combinations are inconsistent, coating oat husks—especially with linseed oil—works well in delaying particle degradation and improving mechanical strength compared to untreated particles. Furthermore, when aggregates are substituted with the longer and lamellar particles of oat husk, the impact of the water/cement ratio on mechanical performance and composite workability significantly decreases.
Rice Husk-Based Insulators: Manufacturing Process and Thermal Potential Assessment
Authors: Cigarruista Solís Luis , Chen Austin Miguel , Deago Euclides , López Guillermo , Marin-Calvo Nacari
Published: May 2024

The development of bio-insultation materials has attracted increasing attention in building energy-saving fields. In tropical and hot–humid climates, building envelope insulation is important for an energy efficient and comfortable indoor environment. In this study, several experiments were carried out on a bio-insulation material, which was prepared by using rice husk as a raw material. Square rice husk-based insultation panels were developed, considering the ASTM C-177 dimensions, to perform thermal conductivity coefficient tests. The thermal conductivity coefficient obtained was 0.073 W/(m K), which is in the range of conventional thermal insulators. In a second phase of this study, two experimental enclosures (chambers) were constructed, one with rice husk-based insulation panels and the second one without this insulation. The measures of the temperatures and thermal flows through the chambers were obtained with an electronic module based on the ARDUINO platform. This module consisted of three DS18B20 temperature sensors and four Peltier plates. Daily temperature and heat flux data were collected for the two chambers during the dry season in Panama, specifically between April and May. In the experimental chamber that did not have rice husk panel insulation on the roof, a flow of up to 28.18 W/m2 was observed, while in the chamber that did have rice husk panels, the presence of a flow toward the interior was rarely observed. The rice husk-based insulation panels showed comparable performance with conventional insulators, as a sustainable solution that takes advantage of a local resource to improve thermal comfort and the reduction of the environmental impact.
Heterogeneous Multi-Phase Grains Improving the Strength-Ductility Balance in Warm-Rolled Fe-18Mn-3Ti Steel
Authors: Li Yifeng , Liu Shulin , Xia Yuanguang , Xu Juping , Chen Huaican , Yin Wen
Published: May 2024

The thermal properties, microstructure, and mechanical properties of Fe-18Mn-3Ti (wt%) were investigated, focusing on the effects of different heat-treatment processes. Results revealed that the 450 °C warm-rolling sample (450 WR) exhibited promising mechanical properties. Specifically, this sample displayed a yield strength of 988 MPa, an ultimate tensile strength of 1052 MPa, and total elongation of 15.49%. Consequently, a favorable strength-ductility balance was achieved. The strain-hardening ability surpassed that of the cold rolling sample (CR). Microstructure analysis indicated the simultaneous occurrence of dynamic equilibrium between grain deformation and re-crystallization because of the co-influence of thermal and strain in the warm rolling process. This desirable mechanical property was attributed to the presence of a multi-phase (α-martensite, austenite, and ε-martensite) and heterogeneous microstructure. The improvement of ultimate tensile strength was based on grain refinement, grain co-deformation, and the transformation-induced plasticity (TRIP) effect in the early stage of plastic deformation (stage Ⅰ). The improvement of ultimate elongation (TEL) was ascribed to the TRIP effect in the middle stage of plastic deformation (stage Ⅱ).
Study on Calculation Method of Bending Performance of Concrete Sandwich Composite Slab
Authors: Cheng Mai-Li , Hu Guo-Zhuang , Wang Hong-Qi
Published: May 2024

In order to explore the flexural behavior of a concrete sandwich panel under concentrated boundary conditions, based on Kirachhoff’s elastic thin plate theory in this paper, the geometric deformation, physical conditions, and equilibrium relationship of a sandwich panel are deduced by constructing the layered analysis model of the sandwich panel, the basic differential equation of the flexural deformation of the concrete sandwich thin plate is obtained, and the mathematical expression of the internal force and displacement under the boundary condition of concentrated support is given. Combined with an engineering example, the proposed calculation method is verified. The results show that, in the arrangement of reliable connectors for concrete sandwich panels, the concrete wythes bear the load while the contribution of the core layer to the bending capacity of the structure can be ignored. When subjected to a laterally distributed load, the sandwich panel mainly experiences out-of-plane bending deformation, and the bending normal stress in the concrete panel layer shows a linear non-uniform distribution along the thickness direction of the panel. The bending deformation performance and bearing efficiency of a concrete sandwich slab with the change in concentrated support position have significant effects, and the load transfer efficiency can be improved by optimizing the arrangement of supports. Except for small local areas near the supports, the bending stress distribution and deformation behavior of the concrete sandwich panel can be accurately analyzed by the calculation method established in this paper.
Single Crystal Perovskite/Graphene Self-Driven Photodetector with Fast Response Speed
Authors: Liu Xiao , Geng Xiangshun , Dun Guanhua , Wang Zeshu , Du Jingbo , Xie Dan , Yang Yi , Ren Tianling
Published: May 2024

Recently, the combination of two-dimensional (2D) materials and perovskites has gained increasing attention in optoelectronic applications owing to their excellent optical and electrical characteristics. Here, we report a self-driven photodetector consisting of a monolayer graphene sheet and a centimeter-sized CH3NH3PbBr3 single crystal, which was prepared using an optimized wet transfer method. The photodetector exhibits a short response time of 2/30 μs by virtue of its high-quality interface, which greatly enhances electron–hole pair separation in the heterostructure under illumination. In addition, a responsivity of ~0.9 mA/W and a detectivity over 1010 Jones are attained at zero bias. This work inspires new methods for preparing large-scale high-quality perovskite/2D material heterostructures, and provides a new direction for the future enhancement of perovskite optoelectronics.
Microstructure Evolution and Mechanical Properties of 7A52 Aluminum Alloy Thin Sheet Repaired with Friction Stir Surfacing
Authors: Li Xiangxue , Shi Chengcheng , Han Guofeng , Liu Huan , Li Xiaofei , Liu Rui
Published: May 2024

A solid-state repair technique based on surface friction welding is investigated in depth to achieve excellent mechanical properties of damaged 7A52 aluminum alloy. The results show that the yield strength and tensile strength along the repair direction are 436 MPa and 502 MPa, respectively, at a rotational speed of 1400 rpm and a travel speed of 300 mm/min, which are about 157.9% and 129.7% of those before the defects were repaired, respectively, while the elongation is 17.2% compared to the base material. Perpendicular to the repair direction, the yield strength and tensile strength are 254 MPa and 432 MPa, which are 111.4% and 129.7% of those before the defects were repaired, respectively, while the elongation is 11.8% compared to the base material. The mechanical properties of the repaired areas are still improved compared to those of the defect-free sheets. On the one hand, this is attributed to the dynamic recrystallization of the nugget zone due to the thermo-mechanical coupling, resulting in the formation of a fine, equiaxed grain structure; on the other hand, the precipitated Mg2Si phase, which is incoherent within the base material, transforms into the Al12(Fe, Mn)3Si phase, as well as the precipitation of the Al6Mn phase and η′ phase, resulting in the enhancement of the properties. The material fracture at the junction of the nugget zone and the heat-affected zone occurs after repair, which is attributed to the significant difference in the texture of the nugget zone and the heat-affected zone, as well as to the stress concentration at the junction.
Investigation of Hydrophysical Properties and Corrosion Resistance of Modified Self-Compacting Concretes
Authors: Zhagifarov Adlet M. , Akhmetov Daniyar A. , Suleyev Dossym K. , Zhumadilova Zhanar O. , Begentayev Meiram M. , Pukharenko Yuryi V.
Published: May 2024

Improvement of hydrophysical properties and corrosion resistance of self-compacting concrete to the effects of alternate freezing–thawing and aggressive soils of Southern and Central Kazakhstan is of interest to a wide range of researchers from the side of practical application of the obtained results in construction practice. It is proposed to form a spatially reinforced fine crystalline structure of a cement matrix with the maximum dense packing by using a complex modifier (hyperplasticizer + polymer + microsilica + fibro fibers) in the composition of self-compacting concretes (SCCs). The introduction of the calculated amount of the above additives increases the operational reliability of the current SCC compositions, increasing the water resistance to W16, frost resistance to F = 500, increasing the compressive strength by 20%, and reducing the mass loss of samples during corrosion leaching to 50%. It has been experimentally established that the proposed addition of the complex modifier (hyperplasticizer + polymer + microsilica + fibro fibers) to the SCC composition allows obtaining self-compacting concrete of high quality with improved performance characteristics (compressive strength, water resistance, frost resistance, and corrosion resistance). Studies have shown that the complex modifier-modified SCC compositions have a high degree of resistance in aggressive environments and leaching corrosion. Based on the results of the conducted tests, it is possible to recommend the obtained SCC compositions for the production of building products working in the zone of alternating freezing–thawing and aggressive soils.
Enhancing Adhesion and Reducing Ohmic Contact through Nickel–Silicon Alloy Seed Layer in Electroplating Ni/Cu/Ag
Authors: Wang Zhao , Liu Haixia , Chen Daming , Wang Zigang , Wu Kuiyi , Cheng Guanggui , Ding Yu , Zhang Zhuohan , Chen Yifeng , Gao Jifan , Ding Jianning
Published: May 2024

Due to the lower cost compared to screen-printed silver contacts, the Ni/Cu/Ag contacts formed by plating have been continuously studied as a potential metallization technology for solar cells. To address the adhesion issue of backside grid lines in electroplated n-Tunnel Oxide Passivating Contacts (n-TOPCon) solar cells and reduce ohmic contact, we propose a novel approach of adding a Ni/Si alloy seed layer between the Ni and Si layers. The metal nickel layer is deposited on the backside of the solar cells using electron beam evaporation, and excess nickel is removed by H2SO4:H2O2 etchant under annealing conditions of 300–425 °C to form a seed layer. The adhesion strength increased by more than 0.5 N mm−1 and the contact resistance dropped by 0.5 mΩ cm2 in comparison to the traditional direct plating Ni/Cu/Ag method. This is because the resulting Ni/Si alloy has outstanding electrical conductivity, and the produced Ni/Si alloy has higher adhesion over direct contact between the nickel–silicon interface, as well as enhanced surface roughness. The results showed that at an annealing temperature of 375 °C, the main compound formed was NiSi, with a contact resistance of 1 mΩ cm−2 and a maximum gate line adhesion of 2.7 N mm−1. This method proposes a new technical solution for cost reduction and efficiency improvement of n-TOPCon solar cells.
Effect of Hot-Pressing Process on Mechanical Properties of UHMWPE Fiber Non-Woven Fabrics
Authors: Huang Jiaxiang , Zhang Xiaoping , Gu Tianyi , Zhang Fubao , Niu Yanfeng , Liu Susu
Published: May 2024

In order to investigate the influence of a hot-pressing process on the mechanical properties of ultra-high molecular weight polyethylene (UHMWPE) fiber non-woven fabrics with stretch and in-plane shear, UHMWPE non-woven fabric samples were prepared by adjusting the temperature, time, and pressure of the hot-pressing process, and mechanical property tests were carried out so as to clarify the influence of the hot-pressing process on the mechanical properties of the samples. The results show that the hot-pressing process mainly affects the silk–glue bonding strength of the samples; in the test range, with the increase in hot-pressing temperature and time, the tensile strength and in-plane shear strength of the samples increase and then decrease, and the best mechanical properties are obtained at 130 °C and 7 min of hot pressing, respectively; at 130 °C, the in-plane shear strength is 39.94 MPa and the tensile strength is 595.43 MPa; at 7 min, the in-plane shear strength is 63.0 MPa and the tensile strength is 643.30 MPa; with the increase in the hot-pressing pressure, the in-plane shear strength of the samples increases and then decreases, and the highest is 52.60 MPa, achieved at 8 MPa; in the range of 5–8 MPa, the tensile strength of the specimens did not change significantly, and increased significantly at 9 MPa, reaching a maximum strength of 674.55 MPa.
Magnetically Induced Near-Infrared Circularly Polarized Electroluminescence from an Achiral Perovskite Light-Emitting Diode
Authors: Imai Yoshitane , Amasaki Ryo , Yanagibashi Yoshihiko , Suzuki Seika , Shikura Ryuta , Yagi Shigeyuki
Published: May 2024

Circularly polarized electroluminescent devices are conventionally fabricated by incorporating an optically active chiral luminophore into their emission layer. Herein, we developed a circularly polarized perovskite light-emitting diode (PeLED) system with an optically inactive perovskite luminophore that can emit near-infrared circularly polarized electroluminescence (CPEL) upon application of an external magnetic field. The magnitude of the magnetic CPEL (gMCPEL) was in the order of 10−3 in the near-infrared wavelength range of 771–773 nm. Although the Pb perovskite quantum dots were achiral, the rotation direction of the CPEL of the magnetic circularly polarized PeLED system was successfully reversed by switching the Faraday geometry of the applied magnetic field. The use of achiral luminophores exhibiting magnetic-field-induced CPEL represents a new approach for the development of circularly polarized electroluminescent devices.
Research on Stock Market Risk Contagion of Major Debt Crises Based on Complex Network Models—The Case of Evergrande in China
Authors: Liang Kaihao , Li Shuliang , Zhang Wenfeng , Zhang Chaolong
Published: May 2024

After a major debt crisis occurs in a listed company, the stock prices of related enterprises may also fluctuate sharply, resulting in the spread of debt risk to more enterprises. Taking the stocks of listed companies as network nodes, we constructed a complex stock market network over three periods of time through the logarithmic return rate of stocks for the three periods of prophase, metaphase, and anaphase of the debt crisis. We studied the topological characteristics of the network and destructiveness over the three periods. Finally, the minimum spanning tree was used to construct a network and the community structure of the network. The empirical analysis took the debt crisis of the China Evergrande Company as an example to analyze the impact of its major debt crisis on the Chinese stock market. The research findings were as follows: First, the debt crisis increased the inter-industry connections within the network, that is, the correlations between enterprises in different industries was enhanced. Second, the closeness of the cross-industry connections increased the connectivity efficiency of the network, but compared with the other two periods, the debt crisis in the metaphase was less stable. Third, community research showed that in the metaphase of the debt crisis, the enterprises became the core nodes of the network.
Weight Vector Definition for MOEA/D-Based Algorithms Using Augmented Covering Arrays for Many-Objective Optimization
Authors: Cobos Carlos , Ordoñez Cristian , Torres-Jimenez Jose , Ordoñez Hugo , Mendoza Martha
Published: May 2024

Many-objective optimization problems are today ever more common. The decomposition-based approach stands out among the evolutionary algorithms used for their solution, with MOEA/D and its variations playing significant roles. MOEA/D variations seek to improve weight vector definition, improve the dynamic adjustment of weight vectors during the evolution process, improve the evolutionary operators, use alternative decomposition methods, and hybridize with other metaheuristics, among others. Although an essential topic for the success of MOEA/D depends on how well the weight vectors are defined when decomposing the problem, not as much research has been performed on this topic as on the others. This paper proposes using a new mathematical object called augmented covering arrays (ACAs) that enable a better sampling of interactions of M objectives using the least number of weight vectors based on an interaction level (strength), defined a priori by the user. The proposed method obtains better results, measured in inverted generational distance, using small to medium populations (up to 850 solutions) of 30 to 100 objectives over DTLZ and WFG problems against the traditional weight vector definition used by MOEA/D-DE and results obtained by NSGA-III. Other MOEA/D variations can include the proposed approach and thus improve their results.
Sustainable Evaluation of E-Commerce Companies in Vietnam: A Multi-Criteria Decision-Making Framework Based on MCDM
Authors: Le Minh-Tai
Published: May 2024

This study aims to effectively support decision-makers in evaluating leading e-commerce companies in Vietnam from a sustainability perspective. In addition, this study evaluates and analyzes criteria that affect the performance of e-commerce companies in Vietnam to find the best practices for e-commerce implementation of managers. In this way, companies can save costs and increase marketing and promotion efficiency, helping to reach more customers. In doing so, an integrated framework based on MCDM is proposed for the first time in e-commerce industry assessment. In the first stage, the fuzzy decision making trial and evaluation Laboratory method is applied to determine the weights of 9 criteria based on collected data. This study lists prominent quantitative evaluation criteria, taking into account the sustainability aspect. In the second phase, ranking the top 12 e-commerce companies in Vietnam according to their performance based on these nine criteria was done by applying the neutrosophic fuzzy axiomatic design method. According to an analysis of the data, the external financial assistance coefficient (12.7%) is the most crucial factor determining how competitive international e-commerce businesses are. The results of this study can help underperforming companies make strategic decisions to improve their performance. Integrating these two techniques provides a new method for evaluating global trading companies that have hitherto remained unaddressed in the trading industry and, therefore, leave a gap that needs to be investigated.
Neutron Diffraction Measurements of Residual Stresses for Ferritic Steel Specimens over 80 mm Thick
Authors: Em Vyacheslav , Ivan Karpov , Woo Wanchuck , Mikula Pavol
Published: May 2024

The maximum thickness for ferritic steel specimens’ residual stress measurements using neutron diffraction is known to be about 80 mm. This paper proposes a new neutron diffraction configuration of residual stress measurements for cases that are over 80 mm thick. The configuration utilizes a neutron beam with a wavelength of 1.55 Å diffracted from the (220) plane with a diffraction angle (2θ) of 99.4°. The reason for the deep penetration capability is attributed to the chosen wavelength having enough intensities due to the low cross-section near the Bragg edge and the reduced beam path length (~16 mm) reflected by the large diffraction angle. Neutron diffraction experiments with this configuration can decrease strain errors up to ±150 με, corresponding to a stress of about ±30 MPa.
An Automated Versatile Diagnostic Workflow for Infectious Disease Detection in Low-Resource Settings
Authors: Urrutia Iturritza Miren , Mlotshwa Phuthumani , Gantelius Jesper , Alfvén Tobias , Loh Edmund , Karlsson Jens , Hadjineophytou Chris , Langer Krzysztof , Mitsakakis Konstantinos , Russom Aman , Jönsson Håkan N. , Gaudenzi Giulia
Published: May 2024

Laboratory automation effectively increases the throughput in sample analysis, reduces human errors in sample processing, as well as simplifies and accelerates the overall logistics. Automating diagnostic testing workflows in peripheral laboratories and also in near-patient settings -like hospitals, clinics and epidemic control checkpoints- is advantageous for the simultaneous processing of multiple samples to provide rapid results to patients, minimize the possibility of contamination or error during sample handling or transport, and increase efficiency. However, most automation platforms are expensive and are not easily adaptable to new protocols. Here, we address the need for a versatile, easy-to-use, rapid and reliable diagnostic testing workflow by combining open-source modular automation (Opentrons) and automation-compatible molecular biology protocols, easily adaptable to a workflow for infectious diseases diagnosis by detection on paper-based diagnostics. We demonstrated the feasibility of automation of the method with a low-cost Neisseria meningitidis diagnostic test that utilizes magnetic beads for pathogen DNA isolation, isothermal amplification, and detection on a paper-based microarray. In summary, we integrated open-source modular automation with adaptable molecular biology protocols, which was also faster and cheaper to perform in an automated than in a manual way. This enables a versatile diagnostic workflow for infectious diseases and we demonstrated this through a low-cost N. meningitidis test on paper-based microarrays.
Multifunctional Meta-Devices for Full-Polarization Rotation and Focusing in the Near-Infrared
Authors: Wan Hengyi , Ou Kai , Yang Hui , Wei Zeyong
Published: May 2024

The creation of multi-channel focused beams with arbitrary polarization states and their corresponding optical torques finds effective applications in the field of optical manipulation at the micro-nanoscale. The existing metasurface-based technologies for polarization rotation have made some progress, but they have been limited to single functions and have not yet achieved the generation of full polarization. In this work, we propose a multi-channel and spatial-multiplexing interference strategy for the generation of multi-channel focusing beams with arbitrary polarization rotation based on all-dielectric birefringent metasurfaces via simultaneously regulating the propagation phase and the geometric phase and independently controlling the wavefronts at different circular polarizations. For the proof of concept, we demonstrate highly efficient multi-channel polarization rotation meta-devices. The meta-devices demonstrate ultra-high polarization extinction ratios and high focusing efficiencies at each polarization channel. Our work provides a compact and versatile wavefront-shaping methodology for full-polarization control, paving a new path for planar multifunctional meta-optical devices in optical manipulation at micro–nano dimensions.