bluuebunny/crossref_metadata_2025 huggingface dataset:
Residence location, medication adherence and family knowledge in patients with schizophrenia
Authors: Herawati Vitri Dyah , Indriyati Indriyati , Sutrisno Sutrisno
Published: September 2024

Background: Schizophrenia is a neurological disorder impacting perception, thinking, language, emotions, and social behavior. Continuous treatment and care are essential to prevent relapses, allowing patients to lead productive lives.
Purpose: To know the relationship between residence location, medication adherence, and family knowledge in patients with schizophrenia
Method: This quantitative study employed a correlation analytical research design and a cross-sectional approach. Independent variables (family knowledge and residence location) and the dependent variable (compliance) were measured simultaneously at one point in time. The research took place at the Surakarta Mental Hospital on May 15, 2022, with a sample of 93 respondents selected through purposive sampling.
Results: The residence location does not significantly impact medication compliance. This is attributed to transportation factors among respondents, as evidenced by the chi-square test results (ρ = 0.013; OR = 3.108).
Conclusion: There is a significant relationship between family knowledge and compliance with medication control. And there is no significant relationship between residence location and compliance with control.
Suggestion: For mental health services, it is recommended to increase and disseminate information to patients' families about the importance of follow-up visits for schizophrenia patients. Future researchers should explore additional factors influencing patient compliance with medication control that were not addressed in this study.
Health promotion and health education: Student’s perceptions of early marriage in Bengkulu City, Indonesia
Authors: Hidayat Yance , Saputra Fery Surahman , Pebriani Emy , Hermiati Dilfera , Suyanto Jipri , Sulastri Sulastri
Published: September 2024

Background: Students are individuals in a stage of life characterised by a strong desire to explore and understand themselves and the world around them. At this age or stage, their current knowledge enables them to efficiently find what they need. Nevertheless, there is a notable deficiency in the comprehension and implementation of knowledge among teenagers, rendering them highly susceptible to engaging in behaviours that may detrimentally affect their future prospects. Meanwhile, the rapid progress of technology facilitates teenagers' participation in activities without parental supervision. Thus, we necessitate an alternate methodology that provides kids with a thorough comprehension of sexual education, augmenting their information and prompting them to contemplate it prior to indulging in deviant behaviours during adolescence that may result in early marriage.
Purpose: To investigate the effectiveness of health promotion and health education on students' perceptions of early marriage.
Method: A quantitative study using a quasi-experimental technique with a total of 184 participants was selected for this study using a stratified random sampling method from eight high schools in Bengkulu City. The statistical used a univariate test and paired t-test to assess the influence, and an independent t-test to appraise the effectiveness of alterations according to the school type group. This allowed us to ascertain the appropriateness of this approach for each specific school type.
Results: Health education has a significant effect on student opinions of early marriage. The mean value was 11.1, with a 95% confidence interval ranging from 2.1 to 18.2. The p-value was less than 0.000, indicating a highly significant result. Conversely, the group comparison test revealed that health education yielded greater effectiveness in public high schools as opposed to private high schools.
Conclusion: Health education can be utilized to alter students' perceptions, so enabling knowledge to serve as a foundation for evaluating the challenges they encounter.
News Framing of Islamic Issues in The Post-Reform Film Festival on The Indonesian News Portal
Authors: Shabana Amin , Patrianti Tria , Muksin Nani Nurani , Purnamasari Oktaviana , Sinaga Astriana Baiti
Published: September 2024

Detik.com and Kompas.com, two of Indonesia's largest online news outlets, also covered film festival activities. This study determines the comparative news framing on film festivals by Detik.com and Kompas.com since the 1998 reformation. The main theories employed in this study are news online media, film festivals and news framing. This study employs a qualitative descriptive method with content from internet as data collection. According to Detik.com and Kompas.com, over the last 20 years, Indonesia has hosted 66 film festivals. These two news portals cover it from the perspectives of issue-specific news frames (a total of 145 articles), generic news frames (1,295articles), and generic frames and local spins (36 articles). These findings indicate that both are more interested in covering film festivals with broad themes. Hopefully, the next researchers will apply different methods to investigate the same issue.
Definiują nas zasady i wartości, jakimi się kierujemy. Kodeks środowiska naukowego marketingu
Authors: Waśkowski Zygmunt , Wiktor Jan W.
Published: September 2024

W artykule został zaprezentowany Kodeks środowiska naukowego marketingu, który określa zasady, normy etyczne oraz wartości, jakimi mają kierować się polscy badacze zajmujący się naukową eksploracją obszaru rynku, wymiany handlowej i konsumpcji. Kodeks został przygotowany przez Polskie Naukowe Towarzystwo Marketingu, skupiające przedstawicieli środowiska naukowego specjalizujących się w problematyce marketingu. W artykule dokonano identyfikacji najważniejszych przesłanek powstawania Kodeksu, wskazując między innymi na dwa dokumenty stanowiące podwaliny jego tworzenia, a mianowicie Kodeks etyki pracownika naukowego oraz Magna Charta Universitatum. Silnie zaakcentowano znaczenie etyki oraz odpowiedzialności, jakimi winni kierować się przedstawiciele świata nauki w dążeniu do odkrywania prawdy i jej upowszechniania. Artykuł opierając się na treści Kodeksu środowiska naukowego marketingu ma na celu ukazanie dojrzałości tego środowiska i jego świadomości oraz akceptacji wymaganych zasad postępowania w nauce, ponadto może stanowić pewną inspirację i zachętę dla reprezentantów innych dyscyplin i subdyscyplin do podjęcia dyskusji nad zbiorem zasad i wartości w prowadzonych badaniach naukowych.
Menkul Kıymet Yatırım Ortaklıklarının Nakit Düzeylerinin Karşılaştırılması
Authors: Sönmez Yahya
Published: September 2024

Bireyler tasarruf elde ettikleri birikimlerini yatırım amacıyla çeşitli varlıklara kaynak sağlamaktadır. Yatırımcıları, yatırdıkları varlıklardan yüksek kazanç sağlamayı hedeflemektedirler. Bundan dolayı günümüzde bu hedefe uyan varlıklardan MKYO önemli bir yatırım aracı olmuştur. Menkul kıymet yatırım ortaklıkları önemli rol oynayan yatırım araçlarıdır. MKYO’lar yatırımcıların para biriktirip büyütmelerini ve çeşitli finansal varlıklara eşirim sağlayan yatırım şirketidir. Bu çalışmada amaç, menkul kıymet yatırım ortaklıkların 2018-2022 yılları arasındaki nakit düzeylerini ölçmek ve karşılaştırmaktır. Bu amaçla BIST MKYO endeksine kayıtlı olan firmaların nakit düzeyleri değerlendirilmiştir. Firmaların nakit düzeylerini ölçmeden önce kriterlerin ağırlıklarını CRITIC yöntemiyle ağırlıklandırılmıştır. Daha sonra firmaların nakit düzeylerini ölçmek amacıyla değerlendirmek amacıyla MAIRCA yöntemi kullanılmıştır. Literatürdeki kaynaklardan yararlanılarak, firmaların nakit düzeylerini hesaplamak için finansal oranlar kullanılmıştır. CRITIC yöntemi uygulandıktan sonra, çalışmada en fazla öneme sahip kriter nakit oranı iken; en az öneme sahip kriterler ise finansal kaldıraç oranı, dönen varlık devir hızı oranı, öz kaynak devir hızı oranı ve borçlanma katsayısı oranıdır. Çalışmanın sonucunda araştırılan yıllar itibarıyla; firmaların nakit düzeyi en iyi olan EUYO Yatırım Ortaklıkları iken, nakit düzeyi en düşük olan; yani nakit sıkıntısı çeken firmalar ise yıllara göre değişiklik göstermektedir.
AR-GE HARCAMALARININ FİNANSAL PERFORMANSA ETKİSİ: SAVUNMA SANAYİ ŞİRKETLERİ ÜZERİNE BİR ARAŞTIRMA
Authors: Tepeli Yusuf , Mirgen Çağatay
Published: September 2024

Şirketlerin Ar-Ge faaliyetleriyle yeni ürünler geliştirmesi, mevcut ürünlerine yeni nitelikler kazandırması veya kalite standardını yükseltmesi rekabet üstünlüğü sağlamaktadır. Ayrıca karlılığın arttırılmasının temel yolu olarak görülen maliyet avantajı bakımından da Ar-Ge çalışmaları etkili olmaktadır. Halka açık şirketlerde finansal performansın giderek artması şirket piyasa değerine de olumlu etki yaratmaktadır. Bu bakımdan çalışmada Ar-Ge yoğun çalışan sektör olan savunma sektöründe Ar-Ge harcamalarının finansal performans üzerindeki etkisi araştırılmıştır. Ayrı ayrı kurulan 8 farklı modelden elde edilen bulgulara göre Ar-Ge harcamalarıyla hisse başına temettü ve hisse kapanış fiyatı arasında pozitif yönlü anlamlı bir ilişki olduğu tespit edilirken Ar-Ge harcamaların diğer değişkenler üzerinde etkisi olmadığı görülmüştür.
Askeri Harcamalar, İşsizlik ve Ekonomik Büyüme İlişkisi: Türkiye Üzerine Bir Analiz
Authors: Yıldırım Nuh Ekrem
Published: September 2024

Çalışmanın amacı, Türkiye örneğinde 1988-2022 zaman aralığını kapsayan süreçte işsizlik, ekonomik büyüme, askeri ve askeri olmayan harcamalar arasındaki kısa ve uzun dönemli olası ilişkilerin ARDL eşbütünleşme metodolojisi kullanılarak incelenmesidir. Kısa ve uzun dönemli bulgular ekonomik büyümenin, işsizliği azalttığının; askeri ve askeri olmayan harcamaların ise işsizlikle istatiksel olarak anlamsız olduğunun bilgisini sunmaktadır. Aynı zamanda hata düzeltme terimi, kısa dönemde oluşabilecek bir dengeden sapmanın düzelerek uzun dönemde dengeye ulaştığını belirtmektedir. Bununla birlikte ekonomik büyümeye ilişkin elde edilen bulgu, Türkiye ekonomisinde hem kısa hem uzun dönemde Okun Yasası’nın geçerli olduğu yönünde yorumlanabilmektedir.
Unraveling the germline inheritance of the JAK2F556V gene mutation in familial thrombocythemia: a comprehensive analysis of 11 family members and potential implications for surveillance
Authors: Meggendorfer Manja , Haferlach Torsten , Beykirch Maria K. , Petrides Petro E.
Published: September 2024

Not available.
The Readiness of South Asian Countries Against Marburg Virus Outbreaks: A Perspective
Authors: Kadir Al Kamal Muhammad Shafiul , Shemanto Mohammad Ullah , Umar Tungki Pratama
Published: September 2024

Marburg virus is a deadly and contagious virus that has already become an outbreak in several countries. This letter evaluates the preparedness of South Asian countries for a potential outbreak of the virus, and link it with public health framework, laboratory capacity, surveillance and response system, policy and guideline, and public awareness. It is indicated that the level of preparedness for Marburg virus and other similar diseases in South Asian countries is inadequate, with most countries lacking the necessary framework, policies, and guidelines for effective deterrence and restraint of infectious diseases. There is an urgent need for action to strengthen preparedness and response efforts in the region, including the development of comprehensive policies and guidelines, collaboration between different agencies and departments, and increased public awareness of infectious diseases.
Bangladesh Journal of Infectious Diseases, June 2024;11(1):83-85
Study on Y- Chromosome Microdeletion of AZFc sY239, sY242 and sY254 Loci among Bangladeshi Infertile Male
Authors: Mukta Hazera Akter , Hossain Md Biplob , Islam Sadia , Shohanur Rahaman  , Faruquee Fatima Anjum , Rahman Md Ashiqur
Published: September 2024

Background: Infertility is a global health issue implicated to sociocultural, environmental, health care practice and genetic factors in both male and female individuals. Oligozoospermic and azoospermic conditions reported to be associated with Y chromosome microdeletions (YCDs) in various loci.
Objective: The purpose of the present study was to investigate Y chromosome microdeletions in azoospermic individuals attending fertility clinics, focusing on the SRY239, SRY242, and SRY254 alleles.
Methodology: This cross-sectional study was conducted in the Department of Physiology and Molecular Biology at Bangladesh University of Health Sciences, Dhaka, Bangladesh involving 20 infertile males. Appropriate procedures were followed to address ethical aspects. Demographic and clinical data were collected using structured questionnaire. One milliliter blood sample was collected for DNA extraction and downstream analysis. AZFc markers SY239, SY242 and SY254 alleles were determined by standard polymerase chain reaction (PCR). Data were expressed as number (percent) and figures as appropriate. A value < 0.05 was taken as level of significant.
Results: Age (years) range of the 20 adult infertile azoospermic male was 25-50 with mean (±SD) 39 ±8. Of the 20 subjects 15 (75%) was smoker, 5 (25%) hypertensive and 2 (10%) diabetic. By profession their distribution includes day labors 4 (20%), businessman 8 (40%), garments workers 4 (20%), hawker 2 (10%) and teacher 2 (10%). Among 2 (10%) garments workers show their AZFc fragments deletions. Of the 20 men, azoospermia factor region (AZFc) SRY239 and SRY254 allele deletion were present in 4 individuals. The AZFc variant allele SRY242 was normal in all 20 men. Of the 4 individual present the SRY239 and SRY254 2 were obese.
Conclusion: Y-chromosome microdeletion AZFc region allele markers SRY239 and SRY254 are present in azoospermic male but the AZFc SRY242 was of wild type. Presence of candidate allele detection did not show any relationship with study variables possibly due to small number of samples. To reach conclusive finding of AZFc mutations affecting male infertility, study need to be confirmed by recruiting substantial number of cases and carrying out the investigation at the early stage.
Bangladesh Journal of Infectious Diseases, June 2024;11(1):22-29
Nitric Oxide Acts as an Early Diagnostic Tool for Intrauterine Diseases in Animal Health
Authors: Artyushina Zinaida , Fedotov Sergey , Serezhenkov Vladimir , Sidnev Nikita , Zherebtsov Ilya , Regan Reddy Gade , Muradyan Zhora
Published: September 2024

Background: Intrauterine pathologies in animals are a significant cause of reduced reproductive performance and symptomatic infertility, leading to economic losses in the livestock industry. Early diagnosis of these conditions is critical for effective treatment and management.
Objective: The study aimed to develop a method for the early diagnosis of intrauterine pathologies in animals by assessing nitric oxide (NO) levels using Electron Paramagnetic Resonance (EPR) spectroscopy.
Methodology: An experimental model was created using dairy Escherichia coli culture, which was injected into the uterus of pregnant rabbits under ultrasound guidance. Determination of the level of nitric oxide was accessed in the laboratories of the FSSI "Federal Research Center for Chemical Physics named after. N.N. Semenov" Russian Academy of Sciences. The study involved three groups of rabbits: two groups infected either intrauterine or intraperitoneally, and a control group. Group I (Intrauterine Infection) consisted of two rabbits. A suspension of Escherichia coli was injected directly into the uterus through the cervical canal to induce an intrauterine infection. Group II (Intraperitoneal Infection): This group included five rabbits. The Escherichia coli suspension was administered intraperitoneally, serving as a comparative model for systemic infection. Group III (Control): The remaining two rabbits served as the control group. These rabbits were not infected and were used to establish baseline measurements for comparison.
Results: The results demonstrated that the concentration of nitric oxide derivatives, specifically nitrites and N-nitrosamines (RNNO), significantly increased in the blood plasma of infected rabbits compared to the control group. These changes were observed during the early stages of inflammation, indicating the onset of intrauterine pathologies.
Conclusion: The developed method based on measuring nitric oxide derivatives in blood plasma is effective for the early diagnosis of intrauterine pathologies in animals.
Bangladesh Journal of Infectious Diseases, June 2024;11(1):52-58
Internet Addiction and Social Appearance Anxiety: A Meta-Analysis
Authors: Kaya Bilal
Published: September 2024

The purpose of the present study is to analyze average effect size of the relationship between internet addiction and social appearance anxiety utilising the meta-analysis method. The study included 23 studies published between 2016 and 2022, and the study sample was composed of Turkish participants. The number of participants was 8957. Analysis results showed that the heterogeneity was significant and high. The general effect size was found to be significant in the relationship between internet addiction and social appearance anxiety, it had a medium effect size. However, moderating roles of the year of publication and education level were not found to be significant. Funnel plot analysis was performed to determine publication bias. Egger’s regression test was also performed, which was not significant at a 95% confidence interval. No significant difference was found between observed in Duval and Tweedie’s trim and fill test and corrected effect size. All these analyses indicate that there is no publication bias. The findings of the present study are discussed on basis of the relevant literature.
ZÁSADY TVORBY ZÁVEREČNEJ PRÁCE
Authors:   Univerzita Pavla Jozefa Šafárika v Košiciach, Junger Ján
Published: September 2024

Učebné texty Zásady tvorby záverečnej práce (ZP) sú primárne určené pre študentov 3. ročníka s možnosťou ich využitia v nižších ročníkoch. Svojou štruktúrou zodpovedajú postupu pri písaní ZP. V prvej kapitole sumarizujú základné zákony a usmernenia týkajúce sa napísania a obhajoby ZP. V kapitolách 2 – 8 ponúkajú študentom informácie o výbere témy, formulácii výskumného problému, teoretickom rozbore, cieli práce a metodike výskumu. Deviata kapitola je zameraná na spracovanie a rozbor výsledkov a v desiatej sa nachádzajú inštrukcie ako spracovať záverečnú časť ZP. Súčasťou učebných textov sú aj zásady uvádzania bibliografických odkazov.
Heterogeneidad no observada en la satisfacción laboral del docente universitario
Authors: Correa Osuna Dalia Carolina , Flores Gutiérrez José Ovidio , Flores Márquez Sandra Lizbeth
Published: September 2024

Esta investigación pretende identificar la heterogeneidad no observada presente en el modelo que explica la satisfacción laboral (SATL) de docentes universitarios a partir del capital relacional (CREL) y la violencia en el trabajo (VIOT), en una muestra de 335 profesores de una universidad pública en Venezuela, uno de los países más violentos del mundo. Este abordaje se sustenta en que el supuesto de datos relativamente homogéneos puede ser poco realista en algunos contextos, porque los individuos se comportan de maneras diferentes, lo cual puede afectar bastante los resultados obtenidos con ecuaciones estructurales. La información fue recabada mediante cuestionarios ya validados en la literatura especializada, con formatos tipo Likert-7. Se empleó una investigación de tipo cuantitativo, con diseño transversal y alcance explicativo, y se aplicó una técnica relativamente novedosa denominada PLS-REBUS para identificar tres grupos heterogéneos. Se demostró la fiabilidad y validez de los constructos empleados, cuyas relaciones fueron estadísticamente significativas. Con base en el constructo más influyente en la SATL y la comparación multigrupo, el grupo 1 y grupo 2 representan a los académicos cuya SATL depende principalmente de la percepción del nivel de CREL, cuya etiqueta que distingue su orientación a la SATL es: “lo prioritario son las relaciones institucionales”, y el grupo 3 lo conforman los académicos cuya SATL obedece esencialmente a la percepción del nivel de VIOT en la universidad, cuya etiqueta es: “lo prioritario es la seguridad en el trabajo”.
Cyber Security Analysis of a Power Distribution System Using Vulnerability Assessment and Penetration Testing Tools
Authors: Nidhi R.K. , Pradish M. , Suneetha M. N.
Published: September 2024

The cyber security analysis on a power distribution system, utilizing Vulnerability Assessment and Penetration Testing (VAPT) tools, emphasizes the critical need to evaluate and mitigate cyber security risks for the reliability, integrity, and resilience of these systems. The growing threat landscape faced by interconnected and digitally reliant power distribution systems is discussed, highlighting the severe consequences of potential cyber-attacks. VAPT tools offer an effective approach to identifying vulnerabilities and assessing the security posture. Vulnerability assessment targets weaknesses in software, hardware, and network infrastructure, while penetration testing actively exploits vulnerabilities to gauge system resilience. The analysis aims to identify potential vulnerabilities, evaluate the system’s response to attacks, and provide recommendations for improving overall security. Proactively addressing vulnerabilities and enhancing cyber security defences ensures uninterrupted electricity delivery, safeguards critical infrastructure, and protects against cyber threats in an interconnected world.
Testing of Advanced Metering Infrastructure Systems: Evaluation Process and Analysis
Authors: Dinesh J. , Sinha Shivendra Kumar , Kapoor Shailesh , Agarwal Shyam , Pradish M. , Shivakumar V. , Jain Amit
Published: September 2024

The Advanced Metering Infrastructure comprises a collection of smart meters installed in residential and commercial areas, which gather information on energy consumption and billing from consumer meters and transmit it to the electricity supplier through a communication channel. This infrastructure includes Smart Meters, a communication software platform, a data management system, and a prepaid billing system. This network setup facilitates two-way communication, enabling the efficient monitoring, seamless collection, and analysis of energy data. Electro-mechanical meters are deemed inefficient due to their inefficiency in metering accuracy, susceptibility to theft through direct hooking, and inadequate collection methods. To mitigate these Aggregate Technical & Commercial (AT & C) losses, the Indian Government has introduced the Revamped Distribution Sector Scheme (RDSS). Under this scheme, financial assistance is provided to DISCOMS for enhancing the Prepaid Smart Metering system subject to meeting specific criteria and attaining a minimum benchmark in reforms. This paper aims to present a detailed analysis and evaluation of the testing process for the Smart Meter within the AMI system.
Internal Arc Risk Mitigation Tools for Enhanced Safety and Reliability
Authors: Parwal Kushal , Vishwakarma Sanjeet , Kannadkar Dinesh
Published: September 2024

Low voltage switchgear and control gear assemblies complying with IEC 61439 standards ensure a high level of safety and reliability for its end users. However, a remote possibility of an internal arc fault still exists and hence it is essential to employ risk mitigation tools to enhance safety and reliability. Standard bodies like IEC, IEEE, NFPA etc. provide several methods for making the switchgear assembly more robust from an internal arc standpoint. These include IEC TR 61641, IEEE1584 and NFPA 70E which are a set of available guides and standards. Besides compliance with these standards, several tools are available to mitigate the risk of an internal arc and its associated effects. Here we shall elaborate on the tools that can be used in combination, for reducing the risk associated with an internal arc fault event.
Introduction of a preliminary compressor design and investigation of the influence of fluid properties on compressor performance for mechanical vapor compression
Authors:   Institute of Jet Propulsion and Turbomachinery, Hinz Lars , Goeing Jan ,   Institute of Jet Propulsion and Turbomachinery, Friedrichs Jens ,   Institute of Jet Propulsion and Turbomachinery
Published: September 2024

The German chemical industry is one of the most energy-intensive sectors, which accounts for approximately 8% of Germany’s total energy consumption. One energy-intensive process is distillation, which can be operated as an open heat pump process. This involves compressing steam to a higher pressure level so that the waste heat can be reused to heat the process. The greatest opportunity for this mechanical vapour compression is in the electrification of chemical processes using green energy sources. A preliminary compressor design process for mechanical vapour compression must consider the wide range of possible applications. The preliminary compressor design must take into account other aspects such as different compressor architectures, fluid properties and process boundary conditions. Since the priority is on evaluating the potential of the overall process, generic compressors are used for compressor design. The generic compressor maps can be adjusted by correlation to account for the fluid properties. The influence of the fluid properties on the performance of a centrifugal compressor is investigated using numerical simulation to verify the plausibility that simple correlations can be used to adjust the compressor maps within the preliminary compressor design. With CFD it is shown that the gas properties have a significant influence on the efficiency, the chocking mass flow and the pressure ratio. In addition, various correlations are applied and compared to predict these changes. It is shown that this correlation enables an approximation, but depending on the fluid there are considerable deviations from the CFD calculation.
PENGARUH TRANSAKSI E-COMMERCE, PENGAWASAN PAJAK DAN PEMERIKSAAN PAJAK TERHADAP PENERIMAAN PAJAK (KPP Pratama Kota Kendari)
Authors: Dharmawati Tuti , Yusuf Satira , Wa Ode Mustari i.A  , Fahmi Nurul
Published: September 2024

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruhe-commerce, pengawasan pajak, dan pemeriksaan pajak terhadap penerimaan pajak. Metode penelitian ini menggunakan pendekatan kuantitatif. Penelitian ini melibatkan seluruh restoran di Kota Kendari yang berjumlah 314 restoran. Teknik pengambilan sampel yang digunakan adalah target sampling. Selain itu peneliti juga menggunakan rumus Slovin dalam menentukan sampel dalam penelitian sehingga diperoleh total 76 sampel untuk penelitian ini. Metode pengumpulan data pada penelitian ini adalah kuesioner. Skala pengukuran yang digunakan dalam penelitian ini adalah skala Likert. Data penelitian dianalisis menggunakan regresi berganda melalui software SPSS 25. Hasil penelitian menunjukkan bahwa e-commerce berpengaruh positif signifikan terhadap penerimaan pajak, pengawasan pajak berpengaruh positif signifikan terhadap penerimaan pajak, dan pemeriksaan pajak berpengaruh positif signifikan terhadap penerimaan pajak. Pengawasan dan pemeriksaan pajak secara simultan (bersama-sama) berpengaruh terhadap penerimaan pajak. Hal ini menunjukkan bahwa dengan meningkatnya e-commerce, pengawasan pajak, dan pemeriksaan pajak, maka penerimaan pajak juga akan terkena dampaknya sehingga mengalami peningkatan yang sangat signifikan.
ANALISIS AKUNTANSI PENDAPATAN ATAS SISTEM PEMBAYARAN ASURANSI KESEHATAN BPJS PADA RUMAH SAKIT UMUM DAERAH
Authors: Tamburaka Sulvariany , Purnaman Si , Samawi Adit , Dian Fauziah Vira
Published: September 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis sistem pembayaran asuransi kesehatan BPJS di RSUD kota Kendari dan untuk mengetahui dan menganalisis perlakuan akuntansi pendapatan atas pembayaran asuransi kesehatan BPJS di RSUD kota Kendari. Metode pengumpulan data yaitu wawancara mendalam dan dokumentasi. Metode analisis data pada penelitian ini adalah analisis deskriptif kualitatif. Informan penelitian ini yaitu penanggung jawab casemix dan staf Akuntansi RSUD kota Kendari. Hasil penelitian ini menunjukan bahwa sistem pembayaran asuransi kesehatan BPJS di RSUD kota Kendari menggunakan sistem INA-CBGs, sistem ini rumah sakit dibayar dengan tarif yang sama berdasarkan diagnosa/kasus pasien. Perlakuan akuntansi pendapatan atas pembayaran asuransi kesehatan BPJS di RSUD kota Kendari bahwa pengakuan pendapatan pada RSUD kota Kendari dilakukan dengan menggunakan akrual basic, pengukuran pendapatan dicatat sebesar kas yang diterima atau sebesar nilai wajar imbalan yang diberikan, pengungkapan pendapatan dilakukan dengan cara yang sama sesuai dengan PSAK no 23, pelaporan dilakukan berdasarkan pos masing-masing pendapatan sesuai klasifikasinya kedalam sebuah laporan keuangan.
THE INFLUENCE OF RETURN ON EQUITY (ROE) ON PRICE TO BOOK VALUE (PBV) IN FOOD AND BEVERAGE SUB-SECTOR MANUFACTURING COMPANIES LISTED ON THE INDONESIAN STOCK EXCHANGE
Authors: Hasbudin  , Tamburaka Sulvariany , Dyah Ayu , Angga La
Published: September 2024

This research aims to determine and analyze the effect of Return On Equity (ROE) on Price To Book Value (PBV) in manufacturing companies in the Food and Beverage sub-sector listed on the Indonesian Stock Exchange. The population in this research is the food and beverage subsector manufacturing companies totaling 47 companies listed on the Indonesia Stock Exchange (BEI) for the 2020-2022 period. The sampling method in this research used a purposive sampling technique, so that 13 samples were obtained from 47 companies. The data collection method uses documentation. The research uses a quantitative approach with data analysis methods using simple regression analysis with the help of the IBM SPSS 25 application. The results of this research show that Return On Equity has a significant positive effect on Price to Book Value in Food and Beverage companies listed on the Indonesia Stock Exchange (BEI) in 2020-2022.
ANALISIS STUDI KELAYAKAN BERDASARKAN ASPEK KEUANGAN USAHATANI MERICA
Authors: Wawo Andi Basru , Ramadhan Andi Muhammad Fuad , Utami Aulia Nurul
Published: September 2024

Penelitian ini bertujuan untuk mengetahui apakah pendapatan usahatani merica dapat memberikan pendapatan yang maksimal dan apakah usahatani merica layak di Desa Puncak Monapa. Penelitian ini dilakukan di Desa Puncak Monapa, dengan responden petani. Pengambilan sampel dilakukan secara sengaja (purposive). Data yang digunakan adalah data primer yang di peroleh melalui wawancara dengan petani di Desa Puncak Monapa. Teknik analisis yang digunakan adalah teknik analisis pendapatan dan kelayakan. Hasil penelitian menunjukkan pendapatan yang dihasilkan sebesar Rp 4.504.524 dan kelayakan NPV sebesar 723.771, IRR sebesar 26%, dan BEP produksi sebesar 454 dan BEP harga sebesar Rp 287.339. Usahatani di Desa Puncak Monapa Kecamatan Lasusua Kabupaten Kolaka Utara layak dijalankan dan dikembangkan.
Global Comparison of Real Estate Investment Trusts: Performance and Resilience Throughout the COVID-19 Pandemic
Authors: Chang Takeshi , Khavari Sepehr
Published: September 2024

This study analyzes and compares the performance of Real Estate Investment Trusts (REITs) in several major countries during the course of the global COVID-19 pandemic. It provides a comprehensive evaluation of how the varying REIT markets and sectors responded to unprecedented economic challenges. Several forms of financial analysis were utilized throughout the study. The Fama-French Three-Factor Model was used to investigate at the degree of influence of underlying factors in the REIT market; Cumulative Abnormal Return (CAR) highlights the summative deviation of returns from normal performance of the market. The research findings offer valuable insights for both REIT managers and individual investors; these insights highlight the effectiveness of different strategies in weathering the pandemic and provide actionable recommendations for improving financial resilience in future economic crises.
Computational Analysis of Cohesin Complex Genes and their Role in the Pathogenesis of AML
Authors: Akın Dilara Fatma , Özkan Didem , Bourouba Romyla
Published: September 2024

Objective: Anomalies in the cohesion complex contribute to the pathogenesis of myeloid malignancies by affecting the self-renewal capacity of hematopoietic and progenitor stem cells, but the underlying mechanisms of this phenotype are not fully understood. Therefore, this study aims
to shed light on the relationship between AML pathogenesis and the cohesion complex by comprehensively determining the mutations and expression profiles in the genes constituting the cohesion complex and investigating the effect of expression on survival using bioinformatics databases and tools.
Methods: A total of 96 different mutations were identified in 13 genes. Out of these 96 mutations, 26 were classified as pathogenic/oncogenic. The expression levels of STAG1, REC8, MAU2, CDCA5, and PDS5B were significantly higher in the patient group compared to the healthy group (p< .01). Survival analysis based on low and high gene expression profiles revealed that increased REC8 expression was significantly associated with survival (p= .024), which is considered a prognostic marker. In STRING analysis, it was determined that hub proteins interact with acetyltransferases ESCO1 and ESCO2 involved in sister chromatid cohesion, with TERF1, a component of the telomere nucleoprotein complex, and with PDS5A and BRCA2, which are functionally related to genetic stability and genetic recombination, respectively.
Results: An increase in language outcomes, particularly in repetition, was observed following the treatments. It was also found that therapy gains were more robust following bihemispheric stimulation of the posterior temporal sites compared to the inferior frontal targets.
Conclusion: Overall, none of the target genes except the mutated REC8 showed a significant and independent effect on the clinical outcome defined as overall survival. However, we have identified the diversity of genetic alterations in individual cohesin subunits through comprehensive
molecular analysis. The results may be beneficial in the development of targeted drug therapies and personalized medicine approaches.
Pangenome comparison via ED strings
Authors: Gabory Esteban , Mwaniki Moses Njagi , Pisanti Nadia , Pissis Solon P. , Radoszewski Jakub , Sweering Michelle , Zuba Wiktor
Published: September 2024

Introduction

An elastic-degenerate (ED) string is a sequence of sets of strings. It can also be seen as a directed acyclic graph whose edges are labeled by strings. The notion of ED strings was introduced as a simple alternative to variation and sequence graphs for representing a pangenome, that is, a collection of genomic sequences to be analyzed jointly or to be used as a reference.

Methods

In this study, we define notions of matching statistics of two ED strings as similarity measures between pangenomes and, consequently infer a corresponding distance measure. We then show that both measures can be computed efficiently, in both theory and practice, by employing the intersection graph of two ED strings.

Results

We also implemented our methods as a software tool for pangenome comparison and evaluated their efficiency and effectiveness using both synthetic and real datasets.

Discussion

As for efficiency, we compare the runtime of the intersection graph method against the classic product automaton construction showing that the intersection graph is faster by up to one order of magnitude. For showing effectiveness, we used real SARS-CoV-2 datasets and our matching statistics similarity measure to reproduce a well-established clade classification of SARS-CoV-2, thus demonstrating that the classification obtained by our method is in accordance with the existing one.
Growth independent morphometric machine learning workflow for single-cell antimicrobial susceptibility testing of Klebsiella pneumoniae to meropenem
Authors: Tjandra Kristel C. , Ram-Mohan Nikhil , Roshardt Manuel , Zudock Elizabeth J. , Qu Zhaonan , Mach Kathleen E. , Eminaga Okyaz , Liao Joseph C. , Yang Samuel , Wong Pak Kin
Published: September 2024

Introduction

Multidrug-resistant Enterobacteriaceae are among the most urgent global public health threats associated with various life-threatening infections. In the absence of a rapid method to identify antimicrobial susceptibility, empirical use of broad-spectrum antimicrobials such as carbapenem monotherapy has led to the spread of resistant organisms. Rapid determination of antimicrobial resistance is urgently needed to overcome this issue.

Methods

By capturing dynamic single-cell morphological features, including growth-independent, antibiotic-induced changes, of cells from 19 strains of Klebsiella pneumoniae, we evaluated data processing strategies based on time and concentration differentials to develop models for classifying its susceptibility to a commonly used carbapenem, meropenem, and predicting their minimum inhibitory concentrations (MIC).

Results and discussion

We report morphometric antimicrobial susceptibility testing (MorphoAST), a growth independent, computer vision-based machine learning workflow, for rapid determination of antimicrobial susceptibility by single-cell morphological analysis within sub-doubling time of K. pneumoniae. We demonstrated the technological feasibility of predicting MIC/antimicrobial susceptibility in a fraction of the bacterial doubling time (<50 min). The classifiers achieved as high as 97% accuracy in 20 min (two-fifths of the doubling time) and reached over 99% accuracy within 50 min (one doubling time) in predicting the antimicrobial response of the validation dataset. A regression model based on the concentration differential of individual cells from nineteen strains predicted the MIC with 100% categorical agreement and essential agreement for seven unseen strains, including two clinical samples from patients with urinary tract infections with different responsiveness to meropenem, within 50 min of treatment. The expansion of this innovation to other drug-bug combinations could have significant implications for the future development of rapid antimicrobial susceptibility testing.
Novel RNA biomarkers improve discrimination of children with tuberculosis disease from those with non-TB pneumonia after in vitro stimulation
Authors: Vito Ortensia , Psarras Stelios , Syggelou Angeliki , Wright Victoria J. , Amanatidou Virginia , Newton Sandra M. , Shailes Hannah , Trochoutsou Katerina , Tsagaraki Maria , Levin Michael , Kaforou Myrsini , Tsolia Maria
Published: September 2024

The diagnosis of pediatric tuberculosis (TB) poses a challenge for clinical teams worldwide. TB-mediated changes in the expression of host genes in the peripheral blood can serve as diagnostic biomarkers and can provide better insights into the host immune mechanisms of childhood TB. Peripheral blood mononuclear cells (PBMCs) from children (n=102) with microbiologically confirmed TB disease, TB infection (TBI), pneumonia, and healthy controls (HC) were stimulated with either the Purified Protein Derivative (PPD) or the Early Secretory Antigen 6kDa-Culture Filtrate Protein 10 (ESAT6-CFP10) complex of Mycobacterium tuberculosis (Mtb). RNA was extracted and quantified using gene expression microarrays. Differential expression analysis was performed comparing microbiologically confirmed TB to the other diagnostic groups for the stimulated and unstimulated samples. Using variable selection, we identified sparse diagnostic gene signatures; one gene (PID1) was able to distinguish TB from pneumonia after ESAT6-CFP10 stimulation with an AUC of 100% in the test set, while a combination of two genes (STAT1 and IFI44) achieved an AUC of 91.7% (CI95% 75.0%-100%) in the test set after PPD stimulation. The number of significantly differentially expressed (SDE) genes was higher when contrasting TB to pneumonia or HC in stimulated samples, compared to unstimulated ones, leading to a larger pool of candidate diagnostic biomarkers. Our approach provides enlightened aspects of peripheral TB-specific responses and can form the basis for a point of care test meeting the World Health Organization (WHO) Target Product Profile (TPP) for pediatric TB.
Velocity extraction of nonlinear internal waves by reverberation detecting in shallow water waveguide
Authors: Gao Bo , Li Gongyun , Pang Jie
Published: September 2024

In the realm of shallow water acoustics, reverberation poses a critical challenge to active sonar systems, yet it also serves as a valuable conduit for environmental information. This study presents the findings from a 48-hour experimental investigation of reverberation and clutter in the northern Yellow China Sea, conducted in July 2014. Utilizing temperature and depth sensor arrays, we captured multiple instances of nonlinear internal waves (NIWs). Notably, the reverberation data collected by a vertical array of hydrophones revealed peculiar intensity fluctuations, which were exclusively detected by hydrophones located below the thermocline as NIWs traversed the measurement vessel. To elucidate this phenomenon, we introduce a novel coupled-mode reverberation–clutter theory. Through numerical computations, we determined both the coherent and incoherent components of the reverberation intensities, effectively accounting for the observed target-like intensity variations. The model developed herein was further employed to successfully estimate the velocity of NIWs. These anomalous reverberation characteristics could potentially pave the way for innovative methods of NIW parameter detection in shallow water environments.
Predicting cardiometabolic disease in medical students using FibroScan and 30-year Framingham risk scores
Authors: Sharma Charu , Hashim Muhammad Jawad , Yasin Javed , Alnaqbi Mahra Rashid Salim , Alkaabi Abdulla Saeed Ahmed , Aldhaheri Mohammed Saif Mohammed , Alkaabi Juma , Agha Adnan
Published: September 2024

Introduction

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major cause of end-stage hepatic disease worldwide requiring liver transplantation, whereas cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally. Development of MASLD and CVD among young adults is understudied. This study aimed to assess CVD risk in healthy young medical university students using lipid-based and body mass index (BMI)-based 30-year Framingham risk scores (FS30) and to evaluate disease burden for asymptomatic patients with MASLD by performing FibroScan.

Methods

We included medical university students aged 18–30 years without any known medical conditions. All participants underwent physical and anthropometric measurements, and completed a questionnaire. Blood samples were collected for the analysis of glycosylated haemoglobin levels, renal and liver function, biomarker analysis to calculate liver fibrosis risk, and subclinical atherosclerosis biomarkers. Liver stiffness measurements (LSM) and controlled attenuation parameter (CAP) values were measured using FibroScan 430 mini to calculate liver fibrosis and steatosis, respectively. FS30 based on body mass index (FS30-BMI) and lipid levels (FS30-Lipid) were also calculated.

Results

Overall, 138 medical students participated in this study after providing informed consent. Using FS30-Lipid and FS30-BMI, CVD risk was identified in two (1.5%; n = 138) and 23 (17.6%; n = 132) individuals, respectively. MASLD fibrosis was identified based on FibroScan LSMs >7.0 kPa in 12 medical students (9.4%, n = 128; 95% CI, 4.7–14.8%). Consumption of coffee and sugary soft drinks were predictive of liver fibrosis. In total, 36 students (28.6%; n = 128) were found to have hepatic steatosis based on FibroScan CAP values >236 dB, and the predictive factors included increased body fat percentage, male sex, and lack of physical activity. Levels of inflammatory biomarkers, such as C-reactive protein and lipids were not elevated in participants with MASLD.

Discussion

CVD risk was identified in >17% of young medical students. The frequency of liver fibrosis and steatosis was also high among the participants, indicating that liver damage starts at a relatively early age. Early intervention is needed among young adults via health promotion and lifestyle changes.
User-centered design of a personal-use exoskeleton: a clinical investigation on the feasibility and usability of the ABLE Exoskeleton device for individuals with spinal cord injury to perform skills for home and community environments
Authors: Nadorf Franziska , Wright Mark Andrew , López-Matas Helena , Porras Erika , Carnicero-Carmona Alfons , Hensel Cornelia , Franz Steffen , Weidner Norbert , Vidal Joan , Opisso Eloy , Rupp Rüdiger
Published: September 2024

Introduction

The ABLE Exoskeleton has been tested to be safe and feasible for persons with spinal cord injury (SCI) to complete basic skills in clinical settings but has not been tested for use in home and community environments. A user-centered design process was employed to test the feasibility of the current ABLE Exoskeleton (designed for clinical use) for persons with SCI to perform the basic and advanced skills required for home and community environments, to gain crucial feedback for the development of a novel personal-use exoskeleton.

Methods

In this prospective pretest-posttest quasi-experimental study across two SCI centers (Germany, Spain), in-and outpatients with SCI were included into a 22-session training and assessment protocol, utilizing the ABLE Exoskeleton. Feasibility and usability measures [level of assistance (LoA) for basic and advanced skills, donning/doffing-time and LoA] were recorded together with safety outcomes, and participant and therapist satisfaction with the device.

Results

10 participants (44.4 ± 24 years), with SCI from C5 to T11, (American Spinal Injury Association Impairment Scale A–D) completed the study. In 209 sessions, six device-related adverse events (pain and skin lesions) were reported. Average total time for don and doff was 10:23 ± 3:30 min. Eight participants were able to complete don and doff with minimal assistance or less. Independence to carry out all skills in the device increased significantly for all participants (p < 0.05). Participants with chronic SCI required a significantly (p < 0.05) lower LoA for six of the nine advanced skills than those in the sub-acute phase.

Discussion

This study shows that the ABLE Exoskeleton is safe, feasible and usable for people with SCI in respect to independent donning, doffing and performance of basic and advanced exoskeleton skills. The supervised exoskeleton use in the clinical environment was a highly valuable approach for identifying the challenging tasks and the necessary technological developments that need to be carried out for a personal-use exoskeleton, including a more independent sit-to-stand transition, faster speed of transitions between states and a richer display on the remote control for the user.

Clinical trial registration

https://clinicaltrials.gov/study/NCT05643313.