bluuebunny/crossref_metadata_2025 huggingface dataset:
E-Government in Morocco: Realities, Challenges and Prospects
Authors:   Researcher professor, ENSA Berrechid, Hassan 1st University of settat, Radouane LAKIR , Soukaina HABBOUB ,   Doctoral student, faculty of economics and management, Hassan 1st University of settat
Published: October 2023

In a global context characterized by a digital revolution, digitalization is a growing worldwide phenomenon of the computerization and digitization of the objects or public services that surround us, our professions, or our activities. Digitization offers fast, efficient services that optimize time and costs, reduce regional and social inequalities, and enhance transparency and integrity. It also enables effective and efficient management of public services through access to information, simplification of administrative procedures, and improved relations between the public administration and citizens. In this context, Morocco sees digital technology as a necessary tool for the development of public administration, especially in light of the latest health crisis, which is accelerating the digital transformation of public administration. The aim of this article is therefore to highlight the position of digital administration in terms of digital evolution at the national level and to clarify the prospects for digital development in the Kingdom.
Fifth	antitrust package comes into force
Authors: Galimkhanova N. F.
Published: October 2023

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Current antitrust agenda
Authors: Akimova I. V.
Published: October 2023

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Putting Rurality on the Educational Agenda
Authors: Brennan Marie
Published: October 2023

It is perhaps too easy to suggest that rurality in educational terms has been largely missing from the pages of educational  research texts. A search of the past few AARE annual conference papers throws up few papers on this topic; although an issue ofAustralian Journal of Education includes a paper on long-staying rural teachers (Boylan & McSwann, 1998), while the International Studies in Educational Administration, looks at small country schools in Wales (Huckman, 1998 p.3). However, there are two main areas in which educational research has been active in considering rurality in. education: educational disadvantage for secondary school'students in relation to access to curriculum; and recruitment and retention of teachers.
Working Together for Children
Authors: Collie Louise , Willis Felicity , Paine Crystal , Windsor Corina
Published: October 2023

The Working Together for Children: Strengthening Transition Pathways Team has identified that there is a gap between the Early Childhood settings and schools within the Dubbo area. Through meetings with early childhood professionals within Dubbo we have identified that the current landscape of care and education within our community includes some positive relationships between traditional preschools and schools, however a communication barrier does exist between schools and long day care, family day care and community playgroups, as well as in the home.
Pembangunan Index Budaya Sukan Holistik
Authors: Sharif Shamshuritawati , Elumalai Gunathevan , Mohd Suradi Nur Riza , Mamat Shariffah , Aman Mohd Salleh Bin , Ponnusamy Vellapandian , Ismail Hashbullah , Arshad Mohd Mursyid , Naja Zamri Nur Najmin , Imran Farrah Hani
Published: October 2023

Penyelidikan ini bertujuan untuk membangunkan indeks budaya sukan bagi mengenal pasti tahap budaya sukan rakyat Malaysia serta mengukur isu-isu lain yang berkaitan. Data dikumpul melalui soal selidik yang ditemu bual secara bersemuka. Data kajian adalah daripada persampelan berperingkat berstrata mengikut negeri dalam Malaysia. Terdapat 7857 responden yang berumur sekurang-kurangnya 13 tahun sehingga 60 tahun. Kaedah indeks korelasi digunakan dalam pembangunan indeks Budaya Sukan Malaysia (IBSM) yang holistik. Indeks menggunakan nilai peratusan antara 0 hingga 100; semakin besar peratusannya, semakin tinggi tahap budaya sukan. Hasilnya menunjukkan bahawa tahap penglibatan sukan ialah 73.3%. Dengan mengambil kira semangat kesukanan ke dalam model tersebut, nilai Indeks Budaya Sukan Malaysia ialah 52%. Membahagikan responden kepada beberapa kumpulan mengikut indeks budaya sukan menunjukkan bahawa jantina, status perkahwinan, kumpulan umur, tahap pendidikan dan jenis pekerjaan adalah berbeza secara signifikan. Hasil analisis daripada indeks budaya sukan boleh digunakan untuk memperkayakan dasar negara bagi mewujudkan keadaan yang membolehkan orang ramai membudayakan sukan dalam kehidupan harian. Di samping itu, pendekatan itu boleh digunakan dan disesuaikan untuk negara lain dalam meneroka perkembangan budaya sukan ke arah negara bersukan.
Premises for Protecting the Polish Population in the Context of the National Security Strategy
Authors: Radwański Ryszard , Stochaj Justyna Izabela , Rejman Krzysztof
Published: October 2023

The article’s main objective was to characterize the assumptions of civil protection in Poland in the context of the National Security Strategy of the Republic of Poland as of 2020. As a result of the study, it was found that in the document of strategic importance, which is the National Security Strategy of the Republic of Poland in force since 2020, a lot of attention was paid to the issue of the security of the state and its citizens – the entire first pillar, which is also the main national interest of Poland. Within this pillar, particular importance was attached to the management of national security, state resilience and general defence, the Polish Armed Forces, cybersecurity and information space.
The Prevalence of Drug Abuse as it Relates to Psychosocial Reasons among University Athletes in Selected Competitive Sports in Kenya
Authors: Timothy Ramara , Munayi Simon , Nicholas Bailasha , Janet Chumba
Published: October 2023

Purpose: The main objective of this study was to explore the prevalence of drug abuse as it relates to psychosocial reasons that include peer pressure, social environment, emotional state and relationships; among university athletes involved in selected competitive sports.

Methodology: The study used a mixed methods research design with an intention to capture and utilize both qualitative and quantitative data. The study sample comprised 300 respondents. Out of the 300 students, 173 (57.7%) were male and 127 (42.3%) were female players derived from six selected competitive sports at the universities in Kenya. The selected sports were badminton, tennis, basketball, volleyball, soccer and rugby. Stratified sampling followed by simple random sampling was used to select 10 universities proportionately (4 private and 6 public), the method was the most appropriate to capture universities with women rugby in addition to the five other selected sports. The study sought to investigate the prevalence of drug abuse due to factors such as psychosocial, medicinal and competition. SPSS computer version 20 was used to process data. The data was presented in form of tables.

Findings: Data indicated clearly that athletes had abused drugs due to various psychosocial reasons. The prevalence per gender was close at 18% and 12.12% for males and females respectively. Peer pressure was regarded as a great contributor to drug abuse among the youth. Another psychosocial indicator is the emotional state of a particular individual. Students, just like other members of society, go through various challenging situations in life. The other indicator regarding drug abuse due to psychosocial factors is depression. Four (4, 40%) of the 10 dean of students interviewed said that students were victims of drug abuse due to depression. They alluded the depression cases mostly to relationship issues and financial challenges while the students are in session. The data was presented in form of Tables.

Unique Contribution to Theory, Practice and Policy: Social Learning Theory, Stress-Coping Theory and Social Control Theory may be used to anchor future studies. It is recommended that university athletes be sensitized on proper use of sports to relieve stress and maintain emotional balance. Further, only qualified coaches and sports officers should be allowed to mentor and man sports in the universities. According to some heads of sports seven out of the ten (70%) and 4 of the 10 (40%) deans of students interviewed, some coaches may not report cases of drug abuse by athletes. This could be attributed to the fact that the coaches, who mostly are on casual basis, could fear experiencing bad blood with the players thereby threatening their jobs. Trained sports officers and coaches should accompany the university athletes always and act as worthy mentors to the young athletes.
APPRENTICES PERCEPTION ON APPAREL FIT MADE WITH PATTERN DRAFTING AND FREE-HAND CUTTING METHODS
Authors: Bakker-Edoh Dr. Dymphna , Kofi Kassah Dr. Johnson , Ancelm Kereth Gudila , B. Oigo Dr. Elizabeth , G. Mburugu Prof. Keren
Published: October 2023

Purpose: To assess the perceptions of apprentices on apparel fit made with pattern drafting and free-hand cutting methods.

Methodology: The study employed a cross-sectional descriptive survey was considered adequate for this study as it has the advantage of soliciting respondent’s views on the nature of the situation as it existed at the time of a study. The design is an efficient way of collecting information of a large group of people within a short time using questionnaires. The survey design was deemed appropriate for this study as it has the advantage of seeking the views of informal dressmakers and tailors on the use of pattern drafting and free-hand cutting in apparel construction. It allowed for the use of both quantitative and qualitative techniques in the study. This paved way for better understanding of a phenomenon under study. The use of these methods offered the opportunity to have in-depth information and also the weakness in one method is compensated for by the strength in another method.

Results: respondents agreed that using free-hand cutting method of apparel construction has certain limitations such as its inability to neither produce a perfect fit, takes care of fullness nor bring out the curves among others. Less than one third of the respondents were of the view that free-hand cutting contributed to perfect fit of apparel. Apprentices held a positive view about the use of pattern drafting as providing better fit of apparel as compared to free-hand cutting. It was summed that although free-hand cutting was the main training method used, some styles, because of their unique features, could only be cut with pattern and comes out better than free-hand cutting.

Unique Contribution to theory, practice and policy: The implication is that given the opportunity, training and necessary materials, these apprentices would start using more of pattern drafting than free-hand cutting. Therefore, the study recommended that the IDTA increase the opportunities of pattern drafting training which will lead to more production of better apparel fit.

The study recommended the IDTA should enact policy to incorporate pattern drafting and other methods of apparel construction into the training curriculum of apprentices to develop interest in the use of these methods right from the onset. Additionally, the study suggested future studies to focus on the factors that contribute to the dropouts during the apprenticeship period.
THE ROLE OF SOCIAL MEDIA IN THE INSURANCE INDUSTRY IN KENYA
Authors: Kajwang Ben
Published: October 2023

Purpose: The study examined the role of social media in the insurance industry in Kenya.

Materials and Methods: This study utilized the systematic literature review and focused on previously published academic studies and published journals discussing on social media and insurance firms in Kenya. The study utilized a sample of 12 studies selected randomly from the different academic studies and published journals available at the Google Scholar. This research method was preferred in this study since it is reliable and saves on time and resources as compared to primary data collection methods.

Results: The review of the different studies revealed that the social media provides a variety of platforms that can help insurance firms facilitate the sale of their products, improve their customers interaction and build their brand reputation.  The results of most studies also revealed that social media has a positive and significant impact on the performance and profitability of insurance companies in Kenya. Most of the reviewed studies were also found to discuss the role of social media in the insurance industry to a good extent. However, they consisted of conceptual, geographical and contextual research gaps.

Recommendations: The study recommended that insurance companies in Kenya should invest more on social media platforms such as   Facebook, Instagram, Twitter and LinkedIn which have large target audience and helps to improve customer engagement. Moreover, insurance firms should utilize the available features on these platforms to facilitate online sales transactions, build brand reputation and attract more customers. Policymakers should lessen the strict regulations in the insurance industry that act as barriers to efficient adoption of social media communication and marketing strategies in insurance firms. Further, this study may be relevant to the management of insurance firms by giving a better understanding on how social media can be used to improve some of the operations in these firms. The findings of this study may be helpful to the policymakers as they implement the different policies on digital marketing. Researchers and scholars will also benefit from this study since it adds to the body of knowledge on social media and insurance industry. The identified research gaps in this study will also provide guidance to the future researchers and scholars who may be interested to carry out studies related to the current topic. The study will also give a better understanding on how to use the social exchange theory on studies that surround the social behaviours or social interactions of people.
Impact of Social Media on Strategic Management in Morocco
Authors: Bennani Amira
Published: October 2023

Purpose: The study sought to analyze the impact of social media on strategic management in Morocco

Methodology: The research was conducted entirely on desktop review method. Secondary data, or data that doesn't require actual observation in the field, are the focus of desk research. Because it requires little more than an executive's time, telephone rates, and directories, desk research is generally seen as a low-cost strategy in comparison to field research. As a result, the research used data that had already been collected and reported. This secondary data was readily available via the internet's digital library and scholarly articles.

Findings: The results show that social media has had a profound impact on strategic management. It has enabled organizations to identify and capitalize on opportunities, manage risks, and increase efficiency. By leveraging the power of social media, organizations can gain valuable insights into their customers, competitors, and the market, enabling them to make more informed and effective decisions. Social media has become an increasingly important part of the business landscape and its impact on strategic management in Morocco has been profound.

Unique Contribution to Theory, Practice and Policy: Future research in strategic management may be grounded in either the resource based view theory or the network based view theory. Policymakers, researchers, and academics from all across the world will all stand to gain from this study's findings. The study's findings will also be used by the country's top strategic management executives to boost the effectiveness of social media across all of their operations and initiatives. According to the research, social media organizations may boost their productivity in key areas by adopting rules for dealing with conflicts.
The Impact of Globalization on Strategic Management in Lebanon
Authors: Taqatqa Abdel
Published: October 2023

Purpose: The study sought to analyze the impact of globalization on strategic management in Lebanon.

Methodology: The research was conducted entirely on desktop review method. Secondary data, or data that doesn't require actual observation in the field, are the focus of desk research. Because it requires little more than an executive's time, telephone rates, and directories, desk research is generally seen as a low-cost strategy in comparison to field research. As a result, the research used data that had already been collected and reported. Secondary sources such as internet journals and libraries made this information readily available.

Findings: The results show that the impact of globalization on strategic management is far reaching and has changed the way managers view their roles and responsibilities, the way they think about strategy, and the way they go about developing and implementing strategies. They must also be able to effectively manage resources and operations across multiple countries, as well as develop strategies that are tailored to different global markets. Globalization has led to an increase in competition, a shift in the way organizations approach their customers and markets, and the availability of resources and information. Organizations in Lebanon can leverage the opportunities created by globalization in several ways such as focusing on customer segmentation, leveraging new technologies and expanding their operations in new markets.

Unique Contribution to Theory, Practice and Policy: It is possible that the theories of globalization of markets and transaction costs will serve as the foundation for future research in the field of strategic management. Policymakers, researchers, and academics from all across the world will all stand to gain from this study's findings. The country's senior strategic management executives will also use the study's conclusions to boost globalization across the board. The study suggests that urbanization firms increase the effectiveness of their primary operations and activities by adopting strategic management principles.
A EXTENSÃO ACADÊMICA COMO FERRAMENTA DE PROMOÇÃO DE CONHECIMENTO FRENTE À SEMELHANÇA SINTOMATOLÓGICA NAS SÍNDROMES RESPIRATÓRIAS E GASTROINTESTINAIS
Authors: Gabrielle Izidio de Sousa Ribeiro Ana , Ellen de Almeida Guerra Ana , Pessoa Silva de Bastos André , Bringel Fuentes Hariel , Miranda de Souza Luan Kelves
Published: October 2023

O trabalho evidencia a importância da microbiologia no cuidado integral do ser humano, visando a detecção de microrganismos nocivos à saúde da sociedade. Assim, com o advento da COVID-19 e sua disseminação, os estudos acerca das síndromes virais alavancaram a rede de informações e desencadearam outros métodos de conduta referentes à cada enfermidade. Logo, promover e democratizar o conhecimento sobre as semelhanças e diferenças de cada agente infeccioso torna o cuidado pleno da sociedade possível. Ademais, o projeto “MicroNaMed” trata-se de uma abordagem qualitativa do tipo pesquisa-ação, a partir de uma série de atividades realizadas utilizando novas tecnologias de informação e comunicação, ferramentas pedagógicas inovadoras no projeto. Nesse contexto, os estudantes de medicina desenvolveram competências para construir o conhecimento, de forma autodidata, porém, utilizando grandes referências científicas com o intuito de se autocapacitar, para depois socializar o conhecimento acerca das doenças infecciosas para a comunidade. O projeto foi desenvolvido em três etapas: capacitação interna dos discentes, desenvolvimento de posts informativos na plataforma Instagram e palestras socioeducativas na Unidade Básica de Saúde (UBS) Dona Mocinha - Módulo 38, em Parnaíba – PI. Contudo, espera-se que o projeto auxilie tanto os profissionais da área da saúde, como a comunidade trabalhada em questão, possibilitando um maior entendimento frente aos diagnósticos diferenciais e suas semelhanças sintomatológicas dos principais microrganismos das síndromes patológicas: COVID-19, gastroenterite e influenza.
Influence of Heat Treatment on the Mechanical Properties and Precipitation Kinetic of Sugar Palm Fiber Ash Reinforced LM26 Al Matrix Composites
Authors: Aliyu Isah , Sapuan Salit Mohd , Zainudin Edi Syams , Mohamed Yusoff Mohd Zuhri , Yahaya Ridwan
Published: October 2023

Heat treatment is a commonly known treatment subjected to aluminum alloy and their composites to improve their mechanical properties for automotive, aerospace, and marine applications. The heat treatment was carried out to determine the influence of aging time and temperature on the mechanical properties of LM26 Al alloy reinforced with 0, 2, 4, 6, 8, and 10 wt% sugar palm fiber ash (SPFA) and its precipitation kinetics. The LM26 Al/SPFA composites were fabricated through the stir casting technique, solutionized at 500oC for 2 h, and quenched in water at room temperature. The quenched composites were aged at various ageing times and temperatures and allowed to air cool. The hardness, impact energy, tensile, and compression strengths of the aged composites were appraised. In addition, the precipitation kinetics were studied to validate the precipitation temperatures of LM26 Al matrix composites. The hardness of the composites increased with aging time and temperature, with LM26 Al/10 wt% SPFA composite reaching a hardness peak of 102.10 VH at an aging temperature of 180oC after 5 h, compared to 56.70 VH for LM26 Al alloy. Similarly, after 5 h of aging at 180oC, the LM26 Al/8 wt% SPFA composite achieved maximum tensile and compression strengths of 198.21 MPa and 326.22 MPa, respectively. Precipitation temperature decreased from 584.8oC (LM26 Al alloy) to 480.46oC (LM26/ 10wt% SPFA), indicating that adding SPFA improved precipitation kinetics. The age-hardened composite with high hardness, tensile strength, and compression strength makes it a promising piston material application in the automotive industry.
Development of Sago-based Analog Rice Using Kansei and Value Engineering
Authors: Rizky Septiani Vioretta Putri , Ushada Mirwan , Suharno Suharno
Published: October 2023

This study used two product development methods: Kansei and value engineering. Kansei engineering was used to identify and translate consumer psychological impressions or feelings in the form of Kansei words to the design parameters, while value engineering was used to analyze the functional properties by considering cost, reliability, and performance. The consumers determined the priority attributes of analog rice products, namely a good taste, a fluffy and soft texture, as well as a bright color. Three alternative variations of the product development concept were formulated based on these priorities. The concept with the highest value was then concluded as an analog rice produced from 90% Sago flour and 10% MOCAF (Modified Cassava Flour) with a value of 1,131.
Utilizing Rainwater Harvesting System for Water Scarcity at a Double-Story Residential House
Authors: Rosli Muhammad Izzuddin , Abdullah Sharifah , Mohd Noor Nur Asmaliza
Published: October 2023

The use of rainwater is widely recognized as a dependable solution to reduce and mitigate the effects of water scarcity. Research on rainwater harvesting systems has increased significantly in recent years, especially on methods and treatment systems. A rainwater harvesting system can be described as collecting and storing rainwater that can be used rather than waste as runoff. A rainwater collection system might lessen the reliance on the public water supply. This study aims to determine the suitability of a rainwater harvesting system at a double-story house, thus identifying the suitable tank size for installation. This study’s analysis used the Tangki NAHRIM 2.0 with localized input data such as rainfall, suitable roof area, and roof runoff coefficient. Findings from this study indicate that installing the rainwater harvesting system at a double-story house is suitable, and the optimum tank size is 3m3 by considering all the activities that contribute to water usage. Concisely, installing a rainwater harvesting system can reduce the monthly water bill and minimize the usage of treated water, thus preventing water scarcity in the future.
Automated Cell Counting using Image Processing
Authors: Hassan Dewi Kartini , Suhaimi Hazwani , Bilad Muhammad Roil , Abas Pg Emeroylariffion
Published: October 2023

Manual cell counting using Hemocytometer is commonly used to quantify cells, as it is an inexpensive and versatile method. However, it is labour-intensive, tedious, and time-consuming. On the other hand, most automated cell counting methods are expensive and require experts to operate. Thus, the use of image analysis software allows one to access low-cost but robust automated cell counting. This study explores the advanced setting of image processing software to obtain routes with the highest counting accuracy. The results show the effectiveness of advanced settings in CellProfiler for counting cells from synthetic images. Two routes were found to give the highest performance, with average image and cell accuracies of 85% and 99.8%, respectively, and the highest F1 score of 0.83. However, the two routes were unable to correctly determine the exact number of cells on the histology images, albeit giving a respectable cell accuracy of 79.6%. Further investigation has shown that CellProfiler is able to correctly identify the bulk of the cells within the histology images. Good image quality with high focus and less blur was identified as the key to successful image-based cell counting. To further enhance the accuracy, other modules can be included to further segment an object hence improving the number of objects identified. Future work can focus on evaluating the robustness of the routes by comparing them with other methods and validating with the manual cell counting method.
Organization of FPGA-based Devices in Distributed Systems
Authors: Maidan Mykhailo , Melnyk Anatoliy
Published: October 2023

The article proposes using Kubernetes (k8s) as a tool for managing FPGA-based devices in a distributed system. This can help automate programming, monitoring, and controlling the state of devices, and also optimize resource usage, ensure high availability and reliability, and provide security and privacy for data processed by specialized processors. The article provides a practical example of integrating an FPGA-based device into a Kubernetes cluster. It will help to scale, maintain and monitor distributed systems with millions of devices and manage such big systems from one place by using Kubernetes API. Also, it will help to integrate other third-party tools into the system, which makes it to possible to extend the systems. As a future work, the proposed approach can help integrate FPGA and its real-time reconfiguration tool into a distributed system, making it possible to control FPGA on different IoT devices. Overall, using k8s to manage FPGA-based devices can provide significant advantages in such fields as telecommunications, information technology, automation, navigation, and energy. However, the implementation may require specialized skills and experience.
Microbiological contamination of the inner surface of finished water filling taps at bottled drinking water producers in Khanh Hoa province
Authors: Le Quoc Phong ,   Pasteur Institute in Nha Trang, Khanh Hoa, Vietnam
Published: October 2023

The finished water filling tap is the final contact point of filtered drinking water before bottling. Therefore, microbial contamination at this site may result in cross-contamination into the finished water in the bottle. This study was conducted to evaluate microbiological contamination on the inner surface of the finished water filling tap at the bottled drinking water producers in Khanh Hoa in 2022. A total of 93 swab samples of the inside surface of the tap at 93 producers were subjected to a test for ATP (Adenosine Triphosphate), total plate count (TPC), coliform, Escherichia coli, Pseudomonas aeruginosa, Streptococci feacal, and Clostridia. There were 72/93 (77.4%) samples with ATP values higher than 300 RLU/cm2. The geometric mean of ATP and TPC were 3.1±0.8 log (RLU/cm2) and 3.5±1.2 log (CFU/cm2), respectively. The ATP and TPC were linear correlated, indicating that the surface ATP value inside the finished water filling tap was mainly formed by microorganisms. In addition, 6/93 (6.5%) samples were found to be positive for coliform, including 3 strains of Enterobacter cloacae, 2 strains of Klebsiella pneumoniae and 1 strain of Enterobacter aerogenes. Moreover, 1/93 (1.1%) samples were infected with P. aeruginosa. All 7 strains of these bacteria were biofilm producers under laboratory conditions. Our results demonstrated that the cleaning and decontamination of finished water filling taps were not properly processed, thereby increasing the risk of microbial contamination into finished bottled water.
Simultaneous determination of crocin and crocetin in food samples by highperformance liquid chromatography (HPLC-PDA)
Authors: Do Thi Hong Thuy ,   National Institute for Food Control, Hanoi, Vietnam
Published: October 2023

Crocin and crocetin are two bioactive compounds found in saffron and gardenia. In the food industry, due to their natural yellow or orange color, they are used as food colouring. The study was carried out to optimize the high-performance liquid chromatography combined with a photodiode detector (HPLC-PDA) to simultaneously determine the crocin and crocetin content in food. Analytical samples were ultrasonicated with ACN:H2O (1:1, v/v) solvent for 30 minutes. The sample solution was determined by HPLC – PDA with the following conditions: Sunfire C18 column (250 mm x 4.6 mm; 5 µm) mobile phase consisting of 0.1% formic acid and ACN using gradient program. The method has good specificity, the standard curves of crocin and crocetin have correlation coefficients R2 > 0.999, respectively, repeatability and recovery meet AOAC requirements. The limit of detection (LOD) for  crocin and crocetin were 0.5 mg/kg and 0.25 mg/kg, respectively. The method has been applied to simultaneously determine crocin and crocetin in 15 real samples and results in 13 out of 15 samples detecting crocin content, 11 out of 15 samples detecting crocetin content, and in 2 out out of 15 samples. neither crocin nor crocetin was detected. The gardenia powder group contained the highest content of crocin and crocetin (23.5 g/100g – 24.4 g/100g) and dried lychee samples - sun-dried or dried gardenia contains the second highest concentrations of crocin and crocetin in the food group.
Wound Healing Activity of Transdermal Patches of Carica Papaya, Chromolaena Odorata, and Averrhoa Bilimbi Leaves on Incision Wounds of Hyperglycemic Rat
Authors: Santi Tahara Dilla , Siregar Tongku Nizwan , Sutriana Amalia , Andini Rita , Candra Aditya
Published: October 2023

Transdermal patches have been used for drug delivery to accelerate the wound healing process with minimum negative effect.  This study evaluated the wound healing potential of transdermal patches containing Carica papaya, Chromolaena odorata, and Averrhoa bilimbi leaves extract on hyperglycemic rat as a diabetic wound model. For this purpose, a total of 40 Wistar rats aged 2 - 3 months were randomly distributed into 10 groups.  The first 5 groups (P1, P2, P3, P4 and P5) consisted of normal rats which received normal dressing, TP Dermafix, TP of C. papaya, TP of C. odorata, and TP of A. bilimbi, respectively. The second 5 groups (P6, P7, P8, P9 and P10) were hyperglycemic rats that received normal dressing, TP Dermafix, TP of C. papaya, TP of C. odorata, and TP of A. bilimbi, respectively. Skin incisions were made perpendicular to the spine in the thickest part of the skin with an incision length of 2 cm and a depth of 0.5 cm. Patches were applied to the incisions according to the test group and replaced every 2 days for a period of 13 days. Wound healing activity was determined by evaluating the Clinical Sign of Inflammation (CSI) score, wound closure, TGF-β1 concentration, and histology of skin tissue. Data were analyzed using oneway analysis of variance (ANOVA). The results showed that for each parameter observed, the rats intervened with transdermal patches loaded with extract leaves had higher healing potential and different from the control group (normal dressing without intervene) both in normal and hyperglycemic rats. This made us concluded that the TP loaded with C. papaya, C. odorata, and A. bilimbi extract leaves have potential as wound healing agents and could be considered as alternate to the synthetic transdermal patches.
HIGHLIGHTS

The use of drugs-loaded transdermal patches has been widely studied for the treatment of diabetic wounds, however, the potency of one’s containing Carica papaya, Chromolaena odorata, and Averrhoa bilimbi leaf extracts have not been studied. The present study reports the effectiveness of Carica papaya, Chromolaena odorata, and Averrhoa bilimbi impregnated transdermal patches in treating diabetic rat wounds based on CSI score, histological feature of rat skin and TGF- β concentration.

GRAPHICAL ABSTRACT
Approach for Development of Topical Ketoconazole-Loaded Microemulsions and Its Antifungal Activity
Authors: Naksuriya Ornchuma , Nitthikan Nichcha , Supadej Kanittapon , Kheawfu Kantaporn , Khonkarn Ruttiros , Ampasavate Chadarat , Intasai Nutjeera , Monton Chaowalit , Kiattisin Kanokwan
Published: October 2023

Loading ketoconazole in microemulsions can enhance the solubility and permeation of ketoconazole into the skin. The systematic approach as quality by design (QbD) can help for better product and process understanding. This study aimed to develop topical ketoconazole-loaded microemulsions (KME) based on the QbD approach. After risk assessment, the design of experiment was utilized to determine the optimal ratio of water, isopropyl myristate, and surfactant mixture (polysorbate 80 and ethanol), which were chosen as critical material attributes. The particle size and polydispersity index, selected as critical quality attributes, were evaluated as responses. Then, characterizations, in vitro permeation, cytotoxicity, and antifungal activity studies were tested. As result, the equations from the D-optimal mixture design model successfully predicted the composition of the optimized formulation and obtained the acceptable design space. The optimized KME was 16.00 % w/w of isopropyl myristate, 73.50 % w/w of surfactant mixture, and 8.50 % w/w of water resulted in a water-in-oil system. The particle size and polydispersity index of KME were 21.1 ± 1.6 nm and 0.329 ± 0.020, respectively. KME showed prolonged skin retention after 24 h and was non-toxic. KME exhibited a broader zone of inhibition and lower inhibition concentration compared to unloaded ketoconazole against dermatophytes, indicating that KME enhanced effectiveness in antifungal activity for skin infection. The results of the KME meeting the quality target indicated a well-designed and suitable microemulsion for topical usage. Therefore, employing QbD in identifying the process and formulation is a promising approach for future development of high-quality topical KME products.
HIGHLIGHTS

The topical ketoconazole-loaded microemulsions (KME) were developed based on quality by design approach for further industrial production
The D-optimal mixture design model successfully predicted the design space of desired KME formulation
KME showed prolonged skin retention after 24 h
KME was non-toxic for a topical dosage form
KME exhibited antifungal activity greater than unloaded ketoconazole

GRAPHICAL ABSTRACT
Effects of Ethyl Methanesulfonate on Mutation Induction in Chrysanthemum spp.
Authors: Puripunyavanich Vichai , Chanchula Nattapong , Maikaeo Lamai , Limtiyayothin Mayuree , Orpong Piyanuch , Tamman Arlee , Piriyaphattarakit Anan
Published: October 2023

Mutation induction using EMS agent has been widely and successfully used for variation enhancement. In this study, the cultured plantlets from leaves of 7 chrysanthemum varieties were treated with 0, 1, 1.5, and 2 % ethyl methanesulfonate (EMS) solution for investigation of its efficacy for mutation induction. All treated explants were cultured on MS media supplemented with 2 mg/L 2,4D and 1 mg/L kinetin for callus induction and shoot regeneration. After the plants were cultured for 4 weeks, the percentage of shoot and root initiation and callus formation were observed. The varieties of M07-4, D27, 11-4 and 12-10 showed shoot/root regeneration and callus formation while the M07-14, D23 and 11-8 varieties showed shoot/root regeneration in some bottles. The surviving explants were transferred into the new MS medium supplemented with 1 mg/L BA and 0.1 mg/L NAA to obtain healthy plants ready for planting. The healthy plantlets were transferred to soil pot plants, and grown at Doi Khun Wang, Chiang Mai province, Thailand, for acclimatization. Morphological differentiation was evaluated after 16 weeks of planting in greenhouse. M07-14 varieties showed a maximum of 5 mutant characters. 11-8 varieties showed 4 mutant types while D23, D27, and 12-10 varieties produced 2 mutant types and 11-4 varieties showed only 1 mutant type. EMS proved to be effective in producing mutated chrysanthemum flowering plants that can lead to changes the color and form of flower from the original.
HIGHLIGHTS

Ethyl methanesulfonate (EMS) has been applied to induce mutation in chrysanthemum, which is ranked second in the global cut flower market, for enhancement in varieties and commercial value.
EMS-induced mutation allowed various new characteristics of flower color and form dependent on EMS concentration and variety.
All of chrysanthemum mutants which have the potential to be developed for commercial purpose were cultured in a tissue culture laboratory and prepared for commercial production in the next step.

GRAPHICAL ABSTRACT
ВЛИЯНИЕ СОТС И ПАРАМЕТРОВ КОНСТРУКЦИИ РЕЗЦОВОЙ СБОРНОЙ РАЗВЁРТКИ НА ТОЧНОСТЬ ОБРАБОТКИ
Authors: А. Ж. Касенов  , А. Ж. Таскарина  , А. С. Янюшкин  , Д. А. Искакова  , И. Т. Тукаев
Published: October 2023

"В настоящее время существует большое разнообразие металлорежущих инструментов. Номенклатуру режущего инструмента определяют на основе анализа форм, размеров, требуемой точности и шероховатости основных и дополнительных поверхностей деталей с учётом вида выбранной заготовки. На повышение стойкости и износостойкости инструментов, также при металлообработке, эффективное влияние оказывает применение смазочно-охлаждающих технологических средств (СОТС). Физико-химический механизм действия СОТС достаточно сложен и, в основном, обусловлен изменением условий взаимодействия поверхностей режущего клина инструмента с обрабатываемым материалом, что выражается, прежде всего, в изменении условий контактирования. На основе проведённого анализа конструкций отечественных и зарубежных производителей металлорежущих инструментов сделан вывод, что разработка новых конструкций осуществляется в направлении проектирования сборных конструкций, сменных режущих пластин, а также с применением комбинированных режущих инструментов. Конструктивные особенности резцовой сборной развёртки и качество рабочих поверхностей режущего клина зубьев обеспечивают высокую эффективность чистовой операции развёртывания, повышение точности обработки, а также стойкость инструмента и снижение шероховатости обрабатываемых деталей. Экспериментальными исследованиями обработки отверстий резцовой сборной развёртки на основе методики планирования получены, что качество обработки отверстий резцовой сборной развёрткой с жёстким креплением безвершинных зубьев при применении СОТС увеличивается в 1,2..1,3 раза, вследствие уменьшения температуры и трения в зоне резания. Ключевые слова: резание, СОТС, металлорежущий инструмент, резцовая сборная развёртка, режимы резания, точность, шероховатость."
"CONCEPT OF GENDER EDUCATION IN THE UNIVERSITIES OF KAZAKHSTAN "
Authors: Zh. A. Agabekova  , A. S. Salimzhanova
Published: October 2023

"The fourth technological revolution introduces new changes in the direction and structure of world science. The content of the socio-humanitarian direction has expanded, and new concepts of education have appeared. Gender education is one of the fastest-developing areas of the social sphere of education. In Western countries, gender education began in the second half of the twentieth century and was carried out in Kazakhstan from the first years of sovereignty. The functioning of research centers focused on gender studies has had a beneficial effect on the formation of education in this area. Now half of the universities conduct gender-based disciplines with expanding priority directions. The sphere of gender knowledge, initially covering only the sociological direction, is filled with politics, economics, philology, and history. Gender education is considered as one of the most important components of the educational process of social and humanitarian specialists. Its content includes ideological and universal values. The problem of gender education and the study of the content of gender education are considered in various aspects. In Kazakhstan, gender education, and interdisciplinary connections are not clearly expressed, and the direction is not fully distinguishable. In this article, the gender education in Kazakhstan is studied, and creation of the concept of gender education is studied. Keywords: gender education, Kazakhstan, gender studies, gender-based disciplines, gender knowledge. "
"STUDY OF THE MECHANICAL CHARACTERISTICS OF FDM (3D PRINTED) PARTS: EMPIRICAL AND COMPUTATIONAL METHODS"
Authors: A. Rakishev  , B. Donenbayev  , K. R. Jamaludin
Published: October 2023

"Fused deposition modelling, alternatively referred to as Fused Filament Fabrication, is an additive manufacturing technique that has garnered significant attention across various industries due to its diverse applications. This research investigates the ultimate tensile strength and elastic modulus of 3D-printed Polylactic acid samples, following the ISO-527-2-2012 standard. The mechanical performance of the created parts is considered from both experimental and computational points of view. The finite element method within the ANSYS environment was employed for computer-based load and strength calculations. Tensile specimens are fabricated using the Fused deposition modelling approach. The experimental outcomes were utilised to derive all the essential engineering constants required for evaluating the mechanical behaviour. The validity of the theoretical model has been confirmed through a comprehensive comparison with a substantial volume of experimental data, exhibiting mean errors of approximately 1 %. The objective of this research is to assess the effectiveness and efficacy of analytical models in predicting the structural and mechanical behaviour of components produced through fused deposition modelling. Keywords: additive technology, fused deposition modelling (FDM), PLA, mechanical properties, analytical model."
"Комплексное исследование состава и структурных особенностей железной руды ЛИСАКОВСКОГО МЕСтОРОЖДЕНИЯ"
Authors: Б. Т. Сулеймен  , Н. Ы. Косдаулетов  , Г. А. Адилов  , А. С. Ержанов  , П. А. Гамов
Published: October 2023

"Настоящее исследование посвящено изучению особенностей оолитовой железной руды Лисаковского месторождения. Проведены эксперименты по разложению оолитовой руды в атмосфере воздуха с одновременным контролем температуры и массы образца. Общая потеря массы при обжиге составила практически 15 %. Детальная характеристика химического состава и минералогии сырой и обожженной руды была проведена с использованием оптической и электронной микроскопии, методом рентгенофазового анализа с помощью дифрактометра. Выявлено, что главным рудным минералом оолитовой руды является гётит, который после окислительного обжига трансформируется в гематит. Другим рудным минералом является магнетит, среди неметаллических минералов встречается кварц. Фосфор присутствует в виде гидрофосфата железа и фосфата алюминия. Построена карта распределения основных элементов в исходной руде. Подтверждено, что оолиты образованы преимущественно оксидами железа, присутствуют фазы пустой породы, состоящие в основном из оксидов кремния, кроме того, встречаются и комплексные оксидные фазы, где присутствуют несколько элементов (Fe, Si, Al). Полученные данные могут быть полезны для разработки теории и технологии пирометаллургической переработки оолитовых железных руд с высоким содержанием фосфора. Ключевые слова: железа, железная руда, гётит, гематит, оолит, фосфор, Лисаковское месторождение, окислительный обжиг."
"К ВОПРОСУ ОПТИМИЗАЦИИ СОСТАВА АЛЮМОМАТРИЧНЫХ КОМПОЗИТОВ ДЛЯ ПРОИЗВОДСТВА МАШИНОСТРОИТЕЛЬНЫХ ЗАГОТОВОК "
Authors: Ж. А. Ашкеев  , *М. Ж. Абишкенов  , К. А. Ногаев  , У. Камаров
Published: October 2023

"Работа посвящена оптимизации состава гибридных (трехкомпонентных) алюмоматричных композитов, которые как и наиболее широко используемые в машиностроительной отрасли стальных заготовки, являются прочными, но при этом отличаются от них значительно легким весом и коррозионностойкостью. Предлагается минорная добавка (армирование) в матричный алюминий диборида титана и нанодисперсного диоксида кремния (наносилики), которые оказывают положительное влияние на такие основные механические свойства машиностроительных заготовок как прочность, пластичность, твердость, но при этом не ухудшает характерные для исходного неармированного алюминия антикоррозионные свойства и не приводит к увеличению общей массы машиностроительных заготовок. Для установления зависимости вышеуказанных показателей механических свойств (параметр оптимизации Y) гибридного алюмоматричного композита от содержания армирующих наполнителей (факторы X1 и X2) был проведен предварительный двухфакторный эксперимент с описанием условий его проведения и составлением матрицы планирования, карты проведения эксперимента. Определены коэффициенты регрессии, выявлена их значимость и с использованием значимых коэффициентов получена уравнение регрессии – математическая модель, которая адекватно описывает процесс получения алюмоматричного композита, а также позволяет оптимизировать расход армирующих наполнителей для обеспечения необходимого уровня прочности конечных композитов. Выявлено, что и X1, и X2 значимые и существенно влияют на прочностные и другие механические свойства машиностроительной заготовки из алюмоматричного композита. Адекватность (пригодность) модели проверена критерием Фишера. Работа выполнено в рамках решения задачи по выбору перспективных весовых процентных составов алюмоматричных композитов с научной оценкой и анализом влияния выбранных армирующих материалов на структуру и свойства конечных алюмоматричных композитов посредством методов обработки первичной информации и факторного эксперимента (предварительного) в рамках проекта AP19677907 «Исследование влияния микро/наночастиц, промышленных отходов и сдвига на качество металлических заготовок для машиностроения». Ключевые слова: алюмоматричный композит, диборид титана, наносилика, факторный эксперимент, оптимизация состава, уравнение регрессии, механические свойства, армирование. "