bluuebunny/crossref_metadata_2025 huggingface dataset:
A TEN-YEAR ANALYSIS OF CHANGES IN THE SENSITIVITY
OF THE LEADING UROPATHOGEN TO ANTIBACTERIAL AGENTS
IN CHILDREN WITH URINARY TRACT INFECTION IN THE
NEPHROLOGY DEPARTMENT
Authors: Budnik Tetiana V. , Bevzenko Tetiana B.
Published: October 2020

The aim: To study the prevalence of ABR among children with UTI over the past 10 years, with an assessment of the sensitivity of E. Coli to common antibiotics in dynamics.
Materials and methods: The study involved 1,044 children with UTI aged from 1 month to 18 years. Examination of patients and interpretation of the results was performed
in accordance with the provisions of the Declaration of Helsinki of Human Rights. According to the design, the study included 3 comparison groups: Group 1 — children of the
2009 follow-up year (n = 337), Group 2 — of 2014 (n = 328) and Group 3 — of 2019 (n = 379).
Results: Escherichia coli is recognized as the leading uropathogen in all study groups: its percentage in Group 1 was 47 % (158/337), in Group 2 — 64 % (210/328) and in
Group 3 — 66.5 % (252/379). The prevalence of antibacterial resistance of E. coli strains and the high dynamics of its growth are shown. So the level of resistance of E. Coli in
2019 was 70 ± 4.06 % (176/252). This was 11 % more compared to 2014 and 18.8 % more compared to 2009. The percentage of multiresistant strains tended to increase and
amounted to 28 ± 9.97 % (70/252) among patients with UTI and 40 ± 9.12 % (70/176) in the structure of resistance in 2019. The relative risk of ABR increased by 1.6 times
in 2019 compared to 2014 (RR2019 = 2.208 ± 0.207 [1.473;3.310], р < 0.05 vs RR2014 = 1.375 ± 0.209 [0.913;2.063]) and by 3 times compared to 2009 (RR2009 = 0.727 ± 0.209
[0.483;1.095]). Ampicillin and amoxicillin showed an equally low sensitivity level (3.5 ± 32.14 % (9/252)). Only every second child confirmed sensitivity to cefuroxime
(53.6 ± 5.76 (135/252)). Ceftazidime and ciprofloxacin showed a relatively high sensitivity level — 77.4 ± 3.34 (195/252) and 83 ± 2.81 (209/252), and at the same time
the rapidly growing resistance rates — almost twice as high over the past 5 years. Furazidin K showed a high sensitivity level of 85.7 ± 2.53% (216/252), the lowest level of
overall resistance of 14.3 ± 15.15 % (36/252) and a slow rate of its formation. An unfavourable prognosis of an increase in the relative risk of ABR by 2.9-3.7 times in the next
5–10 years was determined among patients with UTI, provided that the existing diagnostic and treatment approaches are maintained.
Conclusions: The study results are important for understanding the clinical decision on the benefits of antibacterial therapy and optimizing its empirical choice for a patient with UTI.
CARBOHYDRATE AND LIPID METABOLIC PROFILES OF
TUBERCULOSIS PATIENTS WITH BILATERAL PULMONARY
LESIONS AND MYCOBACTERIA EXCRETION
Authors: Shvets Olga M. , Shevchenko Olga S. , Todoriko Liliіa D. , Shevchenko Rostyslav S. , Yakimets Volodumur V. , Choporova Oleksandra I. , Stepanenko Ganna L.
Published: October 2020

The aim: To assess carbohydrate and lipid metabolic profiles of tuberculosis patients with bilateral injuries of the lungs and mycobacteria excretion.
Materials and methods: Seventy two newly diagnosed pulmonary TB patients were examined. Group I – 17 newly diagnosed TB patients who had unilateral pulmonary lesions
and had no mycobacteria excretion. Group II – 55 newly diagnosed TB patients who had bilateral pulmonary lesions and mycobacteria excretion. The control group included 20
healthy persons. Fasting insulin level, indices of lipidogram were measured, oral glucose tolerance test was performed. Statistical processing of the obtained results was carried
out by analyzing the contingency tables using the StatisticaBasicAcademic 13 for Windows software package.
Results: Tuberculosis patients develop insulin resistance – condition that is a precursor to developing type 2 diabetes and metabolic disorder of lipid exchange – dyslipidemia.
Patients with bilateral pulmonary lesions and mycobacteria excretion have the most pronounced disorders of carbohydrate and lipid metabolism compared to patients with
limited lesions of the lungs.
Conclusions: We suppose that mycobacteria excretion and bilateral lesions of lungs may be the markers of the degree of carbohydrate and lipid metabolism disorders in patients
with pulmonary tuberculosis.
KEY WORDS: pulmonary tuberculosis, mycobacteria excretion, glucose metabolism, lipidogram
ASSESSMENT OF THE ADAPTIVE PERSONAL POTENTIAL
OF THE PATIENTS WITH PARANOID SCHIZOPHRENIA
Authors: Mruh Olena F.
Published: October 2020

The aim: assessment of the patients with paranoid schizophrenia adaptive personal potential.
Materials and methods: Clinical-anamnestic method, questionnaires for determining “structural ego-states” by J. Hey, of the “drivers” by M. Cox, of the “personal adaptations”
by Joines, for determining the “crisis moments of development” by J.I. Clark, statistical analysis of the results data.
164 patients with a newly diagnosed and episodic paranoid schizophrenia took part in this study.
Results: “Passive behavior” serves as a typical door for contact by 88% of the patients. According to the methodologies of determination of the “drivers” the following results
were received: “make the others happy” – 28%, “be strong” – 76%, “be perfect” – 65%, “make efforts” – 5% “hurry up” – 15%; of “crisis moments in development” determination,
61% were determined as “stuck” in the 1st stage of the development. By 74%, there was a “script prohibition”, “do not be close.” By 72% there was a “prohibition” “do not have
feelings”. The prevailing combinations of the “personal adaptations” were “schizoid” (92%) and “paranoid” (81%).
Conclusions: schizophrenia can be viewed as a defensive reaction. The “ego- states of the controlling parent” and “adaptive child” dominate. The dominant “drivers” are “make
the others happy” and “be strong.” Typical “script prohibitions” are “do not be close,” “do not feel,” “do not think” and “do not be healthy.” The typical “personal adaptations” of the
patients are “schizoid” and “paranoic”.
ANTIBIOTIC RESISTANCE OF THE NASOPHARYNX MICROBIOTA
IN PATIENTS WITH INFLAMMATORY PROCESSES
Authors: Ivakhniuk Tetiana V. , Holubnycha Viktoriia M. , Smiianov Vladyslav A. , Rudenko Lesia A. , Smiianov Yevgen V.
Published: October 2020

The aim: To study the species composition of microorganisms isolated from patients with inflammatory processes of different localization and to monitor the sensitivity of
isolated microorganisms to the most commonly used antibiotics.
Materials and methods: During 2017–2019, we examined 517 patients with acute inflammatory processes of the nasopharynx. To establish the etiological structure of pathogens
of inflammatory processes, a microbiological study of nasopharyngeal washes was carried out using classical methods of isolation and identification of microorganisms. The
sampling of the test material from patients was performed during the first visit to a doctor, before the appointment and implementation of etiopathogenetic therapy. To study
the sensitivity of isolated microorganisms to antibacterial drugs, we used the method of paper disks (manufactured by “Pharmaktiv” Ltd. (Kyiv, Ukraine) and Himedia (India).
Results and conclusions: The microflora of the mucous membranes of the nose and throat in patients with acute inflammatory processes of the nasopharynx is represented
mainly by monoisolates of staphylococci and streptococci. The sensitivity of isolated microorganisms to antibiotics varied between different types of microorganisms and between
different antibiotics. Cefazolin showed efficacy against all types of microorganisms. K. pneumonia strains showed the highest antibiotic resistance. Among the gram-positive
cocci, 18 strains (4.2%) resistant to all antibiotics were isolated, which can be regarded as the circulation of hospital strains outside the medical institutions.
CONDITIONS OF MICROELEMENTS EXCHANGE PROCESSES
IN WOMEN’S PLACENTS IN INTRAUTERINE INFECTION
OF THE FETUS
Authors: Nikitina Irуna M. , Smiian Svitlana A. , Kondratiuk Kateryna O. , Kalashnyk Natalia V. , Shevel Anzhelika A.
Published: October 2020

The aim: to study the content of trace elements (Fe, Cu, Zn, Co, Cr, Ni, Pb) in the placenta of pregnant healthy women and with signs of intrauterine infection of the fetus, features
of transplacental transmission of infectious process from mother to fetus and to investigate the role of the placenta in trace element supply of the fetus.
Materials and methods. 43 pregnant women between the aged 16 to 40 years were monitored, including 12 with physiological pregnancy (group 1) and 31 with signs of
STI (group 2). All pregnant women underwent standard comprehensive examination, evaluation of fetal cardiac output and non-stress testing using cardio-toсography (CTG)
in the third trimester. The group of pregnant women with signs of fetal ulcers included women whose pregnancy was complicated by chronic fetoplacental dysfunction (FPD),
infectious lesions of the fetoplacental complex, which were diagnosed on the basis of ultrasound signs of placenta, syndrome of infectious and surrounding infections.
Results: The content of essential trace elements in the placenta of the main group was significantly lower than in the placenta of the control group. There was a decrease in
the concentration of iron by 32%, zinc – by 46%, nickel – by 44%, copper more than tripled, chromium – 4 times. Deficiency of essential trace elements (iron, zinc, copper,
chromium, nickel) and elevated lead content in the placenta leads to the formation of conditions for the development of placental dysfunction, the progression of which leads
to fetal distress, developmental delay syndrome and antenatal fetal death.
Conclusions: 1. One of the links in the pathogenesis of intrauterine infection in the fetus is the imbalance of essential trace elements in the system «mother – placenta – fetus».
2. Pregnant women with signs of intrauterine infection are characterized by a deficiency of serum Fe, Cu, Zn, Ni and an increased content of Pb, Cr and Co compared with pregnant
women with physiological pregnancy. 3. Umbilical cord blood of women with evidence of fetal fetal infection also has a reduced content of iron, copper, zinc and high levels of
lead, cobalt and chromium. 4. Disruption of placental function in intrauterine infection of the fetus is caused by reduced content of iron, zinc, copper, nickel and lead accumulation.
CURRENT STATE OF STUDENTS’ HEALTH AND ITS IMPROVEMENT IN THE PROCESS OF PHYSICAL EDUCATION
Authors: Griban Grygoriy P. , Lyakhova Natalia A. , Tymoshenko Oleksii V. , Domina Zhanna G. , Dovgan Nadya Yu. , Kruk Mykola Z. , Mychka Ivan V. , Tkachenko Pavlo P. , Semeniv Bogdan S. , Grokhova Ganna P. , Zelenenko Natalya O. , Prontenko Kostiantyn V.
Published: October 2020

The aim is to investigate the state of health of the students of Ukrainian higher education institutions. Materials and methods: The study of state of health was conducted at Polissia National University and Zhytomyr Ivan Franko State University in 2008-2019. The results of a medical examination of 3737 students of different faculties between the ages of 17 and 22 were examined. Medical examinations were conducted by the doctors of the medical centers of universities. Totally 1208 pupils (male and female) of the schools of Zhytomyr region were involved in the questionnaire, which was conducted to analyze the attendance of physical education classes by pupils while studying at school. 648 students of Polissia National University participated in the study of the self-assessment of their own health, causes, and structure of disease incidence, the dynamics of the loss of labor capacity. Results: It was established that from 24 to 30.8 % of the students had diseases and a low level of physical development that indicated a low level of physical education at schools. It was revealed that the number of sick students was increasing during the study at higher educational institutions (HEI) that led to missing classes. Besides, up to 35.5 % of students had health disorders and belonged to a special medical group. And 1.7 % of the students had chronic diseases and disabilities and were exempted from sports. It was found that physical education and sports took the 5th place in the system of life values of male students and the 12th place in the system of life values of female students. Conclusions: Physical education, aimed at enhancing the functional capacity of an organism, the development of physical qualities, the improvement of the special physical and technical readiness in the sphere of physical activity types and the acquisition of professionally applied skills and abilities, is the basis for strengthening the health of students of Ukraine.
DERMAL ABSORPTION OF DIQUAT AND POTENTIAL
OCCUPATIONAL RISK
Authors: Yastrub Tatyana O. , Omelchuk Sergii T. , Yastrub Andrii M.
Published: October 2020

The aim: The toxicological-hygienic assessment of dermal absorption of diquat in terms of potential risk of its bioavailability in professional use.
Materials and methods: The object of the study was cutaneous exposure of diquat, determined in toxicological experiments of different duration (data of scientific literature) and at the stage of state testing of pesticide preparations based on diquat dibromide (data of a full-scale hygiene experiment, prognostic model of risk assessment), the technical concentrate of diquat dibromide (active substance content not less than 377 g / kg) contains relevant supplements, the content of which is regulated by the Food and Agriculture Organization.
Results and conclusions: Due to the high risk of the diquat adverse effects affecting the personnel, general public and environment, the European Union has introduced
administrative decisions to forbid plant protection products containing the diquat. Fulfillment of the conditions of the Association Agreement between Ukraine and the European Union indicates the need to develop common regulations and risk assessment methods aimed at ensuring high level of protection of human health and the environment.
EFFICACY OF PECTORAL NERVE BLOCK TYPE II VERSUS THORACIC
PARAVERTEBRAL BLOCK FOR ANALGESIA IN BREAST CANCER
SURGERY
Authors: Martsiniv Volodymyr V. , Loskutov Oleg A. , Strokan Andriy M. , Bondar Mihaylo V.
Published: October 2020

The aim: to compare the efficacy of pectoral nerve block type II and thoracic paravertebral block for analgesia during and after breast cancer surgery.
Materials and methods: Sixty adult women were undergoing unilateral radical mastectomy or quadrantectomy with axillary dissection. Patients were randomized to receive
either pectoral nerve block with ropivacaine 0.375% 30 ml or thoracic paravertebral block with ropivacaine 0.5% 20 ml. Evaluated variables included pain intensity at 0, 2, 4, 6,
12, 18 and 24 hours, intraoperative fentanyl, 24-hour postoperative opioid (promedol) and nonopioid (ketoprofen) consumption, the time to first rescue analgesia.
Results: There were no statistically significant differences between pectoral block and paravertebral block groups in intraoperative fentanyl consumption 2,2 (1,81-2,81) vs 1,9
(1,63-2,25) mcg/kg/hour (Р>0,05) and in the pain intensity during the first 24 hours after operation. The mean postoperative 24-hour promedol and ketoprofen consumption
was 4,0 (±8,14) mg vs 5,0 (±8,85) mg (Р>0,05) and 66,7 (±66,09) mg vs 95,8 (±90,78) mg (Р>0,05) in the pectoral and paravertebral block groups respectively. Time to the
first analgesia request was longer in pectoral block group — 540 (455,0-600,0) min vs 515 (265,0-650,0) min (Р>0,05). There were no complications after pectoral blocks and
2 complications after paravertebral blocks.
Conclusions: in breast cancer surgery pectoral nerve block type II can provide postoperative analgesia comparable to thoracic paravertebral block with lower complications rate.
FREQUENCY OF IMPLEMENTATION AND IMPACT OF
APPENDECTOMY AT ACTIVATION OF THE PATHOLOGICAL
PROCESS IN PATIENTS WITH CHRONIC NON-ATROPHIC GASTRITIS
Authors: Avramenko Anatoly A.
Published: October 2020

The aim: Determine the frequency of surgery-appendectomy of patients with chronic non-atrophic gastritis and the impact of this transaction on the pathogenesis of chronic
gastritis.
Materials and methods: Data of disease history and life were analyses, as well as the results of a comprehensive survey of 245 patients with chronic non-atrophic gastritis.
Comprehensive examination included: step-by-step рН-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic
examination of stained smears), histological investigations of the gastric stump mucous.
Results: Helicobacter infection was detected in 100% of cases. It was found that 56 (22.9%) of patients were subjected to appendectomy. Age of patients, who had an
appendectomy ranged from 4 to 40 years and averaged 18.34 ± 1.05 years, and the first pathological manifestations of the gastro-intestinal tract appeared in an average of
28.27± 1.75 year, i.e. in 10 years. As for the age qualification pupil were the earliest pathological manifestations appeared in a group of patients from 11 to 15 years (13 people
(23.2%) and amounted to about 6 years after the operation, and 6 (46.2%) patients, manifestations appeared in 2-6 months after surgery; the most recent is in group from 16
to 20 years (19 people (33.9%) and amounted to about 14 years (p < 0.05).
Conclusions: Surgery on the body of immune system – appendix provokes activation of latent form of chronic non-atrophic gastritis, especially during puberty.
THE FREQUENCY OF VISCERAL AND PHENOTYPIC MARKERS
IN PATIENTS WITH THE COMBINATION OF UNDIFFERENTIATED
CONNECTIVE TISSUE DISEASE AND GASTROESOPHAGEAL
REFLUX DISEASE
Authors: Romash Iryna B. , Mishchuk Vasyl G.
Published: October 2020

The aim: The aim of the research was to study the prevalence of visceral and phenotypic markers of UCTD syndrome in patients with GERD for the purpose of early diagnosis
of this comorbidity.
Materials and methods: The study included 120 patients: 75 patients (Group II) – GERD was on the background of UCTD, 45 (Group I ) – the patients with GERD. The average
age of the patients was 42.05 ± 6.5 years. Evaluations of UCTD’s were performed accordingly to the criteria recommended by M. Moska et al., A. Doria et al., T. I. Kadurina, L. M.
Abbakumova in the modification of T. Milkovskaya-Dimitrova, and the degree of their expression on the scale of T. Y. Smolnova.
Results: Among the examined patients, the specific criteria for the certain connective tissue diseases were detected in the patients with UCTD from 2.7 and 20.0% more often.
Bone, joint and skin phenotypic signs of dysplasia were observed in patients with GERD associated with UCTD by 4-4.5 times more often. Various abnormalities of internal organs
development were detected in the majority of patients of Group II, namely in 88.0%, and only in 6.6% of the patients of Group I. According to the data on daily pH monitoring,
esophagus AET constituted 4.6% of the total monitoring period in Group I and 5.48% in the patients of Group II. The number of refluxes with pH<4 recorded in the patients of
Group I constituted 57±8 episodes, and 79±6 episodes in the patients of Group II.
Conclusions: The obtained data indicated that the number of pathological GER was significantly higher in the setting of comorbidity. Our research also showed that the chances
of diagnosing Reynaud’s Syndrome, arthralgia, unmotivated body weight loss, dysphagia, skin rash, oral ulcers, proximal muscle weakness in the patients with GERD associated
with UCTD are higher in comparison with the patients with GERD without comorbidity (р<0.05). This should necessarily be taken into account in the early diagnosis and when
assigning a complex therapy in case of this pathology.
APPLICATION OF NEURAL NETWORK TECHNOLOGIES
IN THE DENTAL CARIES FORECAST
Authors: Udod Oleksandr A. , Voronina Hanna S. , Ivchenkova Olena Yu.
Published: October 2020

The aim: of the work was to develop and apply in the clinical trial a software product for the dental caries prediction based on neural network programming.
Materials and methods: Dental examination of 73 persons aged 6-7, 12-15 and 35-44 years was carried out. The data obtained during the survey were used as input for the
construction and training of the neural network. The output index was determined by the increase in the intensity of caries, taking into account the number of cavities. To build a neural network, a high-level Python programming language with the NumPay extension was used.
Results: The intensity of carious dental lesions was the highest in 35-44 years old patients – 6.69 ± 0.38, in 6-7 years old children and 12-15 years old children it was 3.85 ±
0.27 and 2.15 ± 0.24, respectively (p <0.05). After constructing and training the neural network, 61 true and 12 false predictions were obtained based on these indices, the
accuracy of predicting the occurrence of caries was 83.56%. Based on these results, a graphical user interface for the “CariesPro” software application was created.
Conclusions: The resulting neural network and the software product based on it permit to predict the development of dental caries in persons of all ages with a probability
of 83.56%.
PERFORMANCE STATUS AND QUALITY OF LIFE AFTER
RECONSTRUCTIONS OF BUCCAL MUCOSAL AND RETROMOLAR
TRIGONE DEFECTS BY SKIN AND FASCIAL FLAPS IN
ONCOLOGYCAL PATIENTS
Authors: Kravets Oleg V. , Fedzhaga Igor P. , Pivtorak Vladimir I. , Fedzhaga Oleg P. , Bulko Iryna V.
Published: October 2020

The aim: of the study is to compare surgical and functional results as well as quality of life after use of skin flaps – platysma myocutaneus flap, supraclavicular artery flap and
fascial flaps – temporoparietal fascial flap, buccal fat pad for plastic closure of the buccal and retromolar trigone mucous surgical defects in cancer patients.
Material and methods: A retrospective comparative analysis of the results of surgical treatment of buccal and retromolar trigone mucosal cancer in 56 patients
operated from 2009 to 2014 was made. The patients were divided into two groups: the first included 26 patients, with reconstruction of fascial flaps, the second
group included 30 patients, with reconstruction of postoperative defects with skin flaps. Surgical results: the average duration of surgery, the average duration of
inpatient treatment and the presence of complications were compared in the both groups. Functional results in both groups were compared in 6 and 12 months after
surgery with the Performance Status Scale for Head and Neck Cancer Patients (PSS-HN), and quality of life was assessed by the University of Washington Quality of
Life questionnaire, version 4.
Results: Average duration of surgery, average time of inpatient treatment, and postoperative complications did not differ significantly in both groups (P> 0.05). Data of
performance status and quality of life in patients with reconstruction of mucosal defects and retromolar trigone with skin flaps were significantly better (P> 0.05) in 6 and 12
months after surgery, compared with the group of patients who underwent defect reconstruction with fascial flaps.
Conclusions: The method of choice in reconstruction of medium and large defects of the buccal and the retromolar trigone mucous is usage of skin flaps: the platysma
myocutaneus flap and the flap of the supraclavicular artery.
CLINICAL AND SEROLOGICAL PARAMETERS OF PROGRESSION
AND PROGNOSIS IN PATIENTS WITH SYSTEMIC SCLEROSIS
– A STATE OF THE ART REVIEW
Authors: Wielosz Ewa , Majdan Maria
Published: October 2020

Systemic sclerosis (SSc) is a multi-organ connective tissue disease that leads to the dysfunction and the impaired morphology of blood vessels due to non-specific inflammation
and progressive fibrosis. Due to the diversity of SSc and even though the factors predisposing to the severe course of SSc are known, it is not always possible to predict the
disease progression and to determine the prognosis. Ideally, the group of patients with faster progression of organ lesions and a worse course of the disease should be identified
and the early intensive treatment should be instituted.
The aim of the article, is an attempt to identify the factors that worsen the prognosis in the course of SSc.
The analysis of numerous studies demonstrated that patients with short-lasting SSc, with the presence of anti-RNA polymerase III antibodies, with a generalized type of SSc with
quickly progressing skin lesions and males should be most strictly monitored. Moreover, vascular complications, tendon ruptures and fast capillaries loss observed in nailfold
capillaroscopy are the factors deteriorating the prognosis in SSc.
In conclusion, despite the known, the factors that worsen the prognosis, it is difficult to predict the course of systemic sclerosis. Due to its incompletely elucidated etiopathology
as well as the diverse and unpredictable nature of the disease, reliable markers to determine the prognosis in SSc have not been found.
IMPLEMENTATION OF DIGITAL TECHNOLOGIES IN HUMAN RIGHTS TO HEALTHCARE
Authors: Marchenko Volodymyr V. , Kilimnik Inna I. , Dombrovska Alla V.
Published: October 2020

The aim: The aim of the study is to examine the blockchain technology in the field of healthcare, to analyze the principles of the European Convention on Human Rights regarding respect for private and family life, home and correspondence, to analyze the key positions of the European Court of Human Rights (hereinafter – ECHR) in the field of human rights to privacy, to analyze the European Union (hereinafter – EU) secondary legislation regarding the supply of medicines, prospects for the blockchain usage in order to protect human rights to privacy and improve the quality of medicines. Materials and methods: Scientific works that are devoted to the outspread of digital technologies in healthcare, the provisions of the European Convention on Human Rights, the ECHR’s practice on the protection of human rights to privacy, the provisions of the EU secondary legislation that regulate the supply of medicines are studied. The methodology of this article is based on comparative and legal analysis techniques and includes system-structural method, method of generalization, method of analysis and synthesis as well. Conclusions: The blockchain technology in medicine and pharmacology will increase the level of protection of human rights to healthcare quality.
NON–NECROTIZING INFLAMMATORY GRANULOMAS (N-NGS) IN THE COURSE OF INFLAMMATORY BOWEL DISEASE – IMMUNOLOGY AND CLINICAL MANIFESTATION OF INTESTINAL AND RESPIRATORY N-NGS
Authors: Rakoczy Igor , Ocetek Marzena , Wiatr Marzena , Zięba Patrycja , Panek Michał , Kuna Piotr
Published: October 2020

The aim:The article describes and summarizes the immunological pathomechanisms controlling the development of non-necrotizing granulomas in the course of non-specific inflammatory bowel diseases (IBD) in lungs and intestines; it also reviews the possible clinical correlations between the processes in the gastrointestinal and respiratory tracts based on the example of Crohn’s disease (CD) and non-specific inflammatory bowel disease (IBC). While the dominant cell subpopulation in ulcerative colitis (UC) is Th2, which produces interleukins IL-4, IL-5, IL-6, IL-10 and IL-13 and Th17 cells; CD characterized by the Th1 cell subpopulation and macrophages predominate, producing IL-23. These are considered to be the key factors crucial for the occurrence of chronic inflammation. Another important causative factor of non-specific inflammatory bowel diseases and granulation is the expression of CD40/CD40L proteins on activated T-cells, i.e. type 2 transmembrane proteins similar to TNF-alpha. However, the interactions between gastrointestinal neuroendocrine peptides/amines (NEPA) and the immune system are believed to have a significant influence on the pathophysiology of non-specific inflammatory bowel diseases and non-necrotizing granulation. The key functions of the immune response of the gastrointestinal tract are managed by the neuroendocrine regulatory system (NES) whose activities govern the production of various hormones including chromogranin/secretogranin, serotonin, vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), substance P, somatostatin or ghrelin.
CONSERVATIVE TREATMENT AS A THERAPEUTIC OPTION FOR
PENETRATING AORTIC ULCER OF THE AORTIC ARCH IN A PATIENT
WITH BICUSPID AORTIC VALVE
Authors: Możeńska Olga , Wojewódzki Michał , Wiligórska Diana , Wiligórska Natalia , Gil Robert J. , Bil Jacek
Published: October 2020

Penetrating aortic ulcer (PAU) is ulceration of an aortic atherosclerotic plaque penetrating through the internal lamina into the media. PAU is a rare condition and occurs in 2%
– 7% of acute aortic syndromes (AAS); however, the actual incidence is unknown because of asymptomatic patients. One may treat it conservatively as well as surgically. We
present a case of a 54-year-old man, who was admitted to hospital due to the exaggeration of exertional chest pain and persistent headaches. During coronary angiography,
the suspicion of PAU was raised. Contrast-enhanced computed tomography confirmed the diagnosis. Transesophageal echocardiography showed bicuspid aortic valve with
minimal calcification, the dilated ascending aorta, large atherosclerotic plaques in the aortic arch with ulceration (thickness: 5.0 – 5.5mm, diameter: 5 – 6 mm, depth: 3 – 4
mm), without intramural hematoma. Conservative treatment was chosen with uneventful 2-year follow-up. Although surgical management is advocated for patients with PAU
type A, we demonstrated that type A PAU can be successfully treated conservatively as well.
HYDROXYCHLOROQUINE IS NO MIRACLE CURE FOR COVID-19
INFECTION –IMAGING AND CLINICAL COURSE IN AN ELDERLY
FEMALE
Authors: Harsch Igor Alexander , Skiba Marcin , Lopatta Eric , Konturek Peter Christopher
Published: October 2020

The risk for an unfavourable course of SARS-CoV-2 pneumonia rises with age and comorbidities. We report the case of an elderly female where the sum of such factors – together
with massive findings in the computed tomography of the lung – led us to a therapy with hydroxychloroquine as a compassionate use. The unfavourable outcome demonstrates
that – despite the enthusiasm of some authors – hydroxychloroquine is no miracle drug. The worldwide SOLIDARITY trial will help clinicians to assess the potential of the
repurposed antimalarial drugs better.
A Note on Embedding the 4-arcs of Fano Plane with Quadric and Cubic Veroneseans to Projective Spaces
Authors: AKÇA Ziya , ALTINTAŞ Abdilkadir
Published: October 2020

The 3-spaces generate intersect pairwise in at least a line (each pair of 4-sets share two points). But since the union of two such 4-sets is a 6-set, this union generates the whole space, so they pairwise intersect in a line. Dually, the lines that we consider have empty intersection. Other examples of such sets are spreads of lines, or spreads of any kind. In this work, we present SCID properties spaces generated by 4-arcs of Fano plane............................................................................
Internal Categories in Crossed Semimodules and Schreier Internal Categories
Authors: TEMEL Sedat
Published: October 2020

In this paper, we characterize internal categories in the category of crossed semimodules and the category of Schreier internal categories within monoids. Then we prove a natural equivalence between their categories. This allows us to produce various examples of double categories.                                                                                                                                                                                                                                                                                                          .
On Crossed Squares of Commutative Algebras
Authors: SOYLU YILMAZ Elis , YILMAZ Koray
Published: October 2020

In this work, we show a categorical property for crossed squares of commutative algebras by defining a specific object in this category and then we give the construction of the pullback with this object. ................................................................................................ ..............................................................................................................................................................................................................
On Slant Helices And Manheim Curves in E^3
Authors: ÇAY Alper , YAYLI Yusuf
Published: October 2020

In this paper, the equation of the ones that provide the Mannheim curve feature in slant helices have been

obtained and the intrinsic equation of Mannheim curves have been given for the first time.

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Testimonios referentes al movimiento de Túpac Amaru II (1784-1812)
Authors: Huertas Lorenzo
Published: October 2020

The investigation of the social struggles in Huamanga that we began in 1969, continues from that moment and day after day new data appears that enrich our knowledge about the social conflicts in the region; for example, in 1971 we presented to the V Congress of American History a small contribution on the repercussion of the Túpac Amaru II movement in Huamanga, a work that was done taking as a reference the Acts of the Cabildo de Huamanga of the years 1780-1781 and also some lawsuits against peasants indirectly related to the Cusco movement. Later, we found another document that contained a trial against Pablo Challco and his family accused of inciting the people of Chungui to rebel against priests and corregidores and for "rekindling" the memory of the great rebel Túpac Amaru. With this interesting contribution again in 1976, a work was published in the anthology made by Flores Galindo. From the analysis of these and other documents on the history of the former bishopric of Huamanga -today the department of Ayacucho- I deduced the following considerations.
El sur andino a fines del siglo XVIII: cacique o corregidor
Authors: O'Phelan Godoy Scarlett
Published: October 2020

Fue después de la rebelión de Túpac Amaru (1780), que finalmente se consiguieron importantes reivindicaciones por las cuales la población campesina había venido luchando insistentemente desde la segunda mitad del siglo XVIII. La disolución de los corregidores y consecuentemente la eliminación de los repudiados corregidores, junto con la abolición del reparto de mercancias (principal succionador de la fuerza de trabajo campesina), constituyeron indudablemente los logros más destacados.
Una rebelión de culíes chinos. Pativilca, 1870
Authors: Rodríguez Humberto
Published: October 2020

En el mes de setiembre de 1870 se produjo una rebelión de culíes chinos que se prolongó a varias haciendas del valle de Pativilca. Todo comenzó en la hacienda de Araya en la parte media del valle, y rápidamente se extendió a otros fundos. Inicialmente fueron cien los chinos sublevados. Al cabo de doce horas los asiáticos eran entre 1,200 y 1,500. El objetivo de los rebeldes fue el mismo en todas las haciendas en donde estalló la revuelta.
El mercado interno y la espontaneidad de los movimientos campesinos (Puno, 1950-1968)
Authors: Claverías Ricardo
Published: October 2020

En este trabajo abordo el estudio de los movimientos campesinos en Puno en el período de 1950 a 1969; es decir cuando el dominio externo adopta nuevas formas de explotación, se reordena la hegemonía de las fracciones del "bloque dominante", y particularmente en el sur del Perú, se inicia el desarrollo industrial-minero como nuevo eje que va a dinamizar el desarrollo del mercado interior. Sin embargo por el tipo de estructura sobre todo en la zona andina y el carácter contradictorio de aquel dominio, el desarrollo del capitalismo va a ser muy lento y doloroso, como se desprende de la exposici´ón en las secciones siguientes.
Apuntes sobre las ocupaciones de tierras y el sindicalismo agrario, 1945-1964
Authors: Flores Galindo Alberto
Published: October 2020

A partir de 1945, en la sierra central, diversas comunidades comienzan a gestionar su reconicimiento oficial, se inician o reanudan engorrosos procesos judiciales entre los comuneros y los terrateniente, algunos de los cuales como en el caso de Huasicancha y la hacienda Laive, se remontaban al siglo XVII, a la vez que en el interior mismo de las haciendas las relaciones de dependencia personal ingresan en una crisis definitiva cuando los colonos comienzan a formar sus primeros sindicatos. El proceso fue interrumpido por el golpe militar acaudillado por Manuel Odría y por los obstáculos dictaoriales que éste impuso a las organizaciones populares y al sindicalismo.
La visión de los vencidos
Authors: Burga Manuel
Published: October 2020

Después de un largo período de preparación, ocasionado en parte por las exigencias del autor para lograr una traducción más fidedigna, podemos ya encontrar en las librerías limeñas un excelente estudio sobre el siglo XVI peruano.
Un Precursor de la Historia Regional
Authors: Tamayo Herrera José
Published: October 2020

La antigua retórica de la época colonial comprendía diversos géneros históricos, que hijos de su época, hoy han periclitado: la Cronología, las Crónicas, los Anales, las Memorias, las Vidas (antiguo y raro nombre de la biografía) y las "Relaciones". Estas últimas, las "Relaciones", pretendían ser la narración fiel de un magno suceso, de un hecho memorable en la vida de una ciudad, que merecía ser perpetuado para el conocimiento de las generaciones futuras. El objeto de las "Relaciones" era la descripción histórica de un hecho único, de una celebración, de una fiesta, que sucedían en un tiempo brevísimo (podríamos decir que en medio del artificio retórico lo que se pretendía era un discurso sincrónico); la aprehensión de un suceso singular, puramente acontecional, limitado a la más corta duración, a un aquí y un ahora contemporáneo del autor.
El Problema del Centralismo en el Perú Republicano
Authors: Caravedo Baltazar
Published: October 2020

En los últimos meses se ha visto con toda claridad la angustia de los pueblos de provincias por encontrar una soluci´´ón a los problemas derivados del actual centralismo limeño. Las diferentes asambleas y frentes populares en los departamentos de Loreto, Cusco, Ayacucho, et., son manifestaciones sociales de un problema en la constitución y naturaleza de la sociedad peruana.
Los Descentralistas Arequipeños en la Crisis del 30
Authors: Rénique José Luis
Published: October 2020

La crisis de los años 30 es una interesante puerta de acceso al estudio del siglo XX peruano en la medida en que en las épocas de crisis las sociedades se revelan y muestran sus tensiones internas. Entre los muchos aspectos que emergieron a la superficie en los agitados años 1930-1933 está el de las diferencias regionales, la cuestión que cobró actualidad luego de varias décaas de latencia, motivando una vigorosa reacción provinciana que Jorge Basadre denominó en Perú: Problema y Posibilidad "La subversión de las Provincias".
El Capitalismo Subdesarrollado y la Organización del Espacio, Perú, 1920-1940
Authors: Slater David
Published: October 2020

He procurado explicar, en otra parte, por qué la geografía del desarrollo contemporáneo está subdesarrollada. Aunque éste no parece ser el lugar adecuado para entrar en una detallada explicación, son pertinentes, sin embargo, algunos comentarios. Así, para ser conciso, deseo argüir que las deficiencias esenciales de la geografía del sub-desarrollo están basadas en una serie de aseveraciones falaces.
Política de precios agropecuarios e ingresos rurales en el Perú
Authors: Figueroa Adolfo
Published: October 2020

¿Alimentos baratos en la ciudad implica necesariamente bajos ingresos en el campo? La respuesta a esta pregunta es tradicionalmente afirmativa. Políticos y economistas coinciden en señalar que el conflicto campo-ciudad es uno de los más dramáticos en los países subdesarrollados. Sin embargo, se conoce poco sobre la importancia cuantitativa que tiene esa relación. En el presente trabajo se hace un examen detallado, con vistas a tal cuantificación, del caso peruano.
Agricultura, agroindustria y dependencia alimentaria
Authors: Lajo Manuel
Published: October 2020

Este artículo presenta una breve reseña del lugar de la agricultura en la economía peruana, sus vínculos con la agroindustria y la dependencia de insumos alimentarios. Dos características centrales pueden dar una idea de la situación de la agricultura en la economía peruana: su estancamiento secular y su estructura de propiedad de tipo latifundio-minifundio, aún después de la reforma agraria.
La agricultura prehispánica en las punas de Junín
Authors: Matos Ramiro
Published: October 2020

Desde hace una década estamos trabajando en la cuenca hidrográfica del Río Mantaro, sierra central del Perú. Este río, en su cauce, entre sus nacientes en la laguna de Chinchaycocha y la desembocadura sobre el río Ene, atraviesa por tres ecosistemas claramente diferenciales: La puna, el valle y la quebrada. Estos segmentos geográficos con cierta unidad en su espacio, a su vez guardan continuidad fisiográfica, biótica y de relieve, desde los 4,200 m. sobre el nivel del mar en el altiplano, hasta los 1,800 m.  en la región selvática. Como ocurre en todo el territorio andino, es igualmente común a los tres sectores, la multiplicidad de nichos ecológicos.
Documentos del Cuzco: historia y poder
Authors: Trelles Efraín
Published: October 2020

Bajo el sugerente título de Cuzco: Aguas y Poder, el Centro de Estudios Rurales Andinos "Bartolomé de las Casas" ha sacado a luz el número 1 de una prometedora serie: Archivos de Historia Rural Andina. En este caso estamos ante la publicación, en una pulcra versión paleográfica de Horacio Villanueva y Jeannette Sherbondy, se seis juegos de documentos vinculados a las aguas y tierras del Cuzco, cuyo arco temporal abarca desde fines del XVI hasta poco menos de mediados del XIX. Nada menos.
Problemas agrarios e historia política en el archivo del Congreso
Authors: Mejía José , Campos Cristina
Published: October 2020

Presentamos aquí un primer reconocimiento* de la masa documental acumulada en el Congreso de la República. Dicha documentación está compuesta por dos grandes colecciones. Una, la más importante, la de la Cámara de Diputados y la otra, la de la Cámara de Senadores. Ambas fuentes, a las que genéricamente denominaremos Archivo del Congreso, representan una de las más importantes series de documentos oficiales existentes en el país tanto por el volumen como por la calidad de los ejemplares que comprenden.
Del sexo, incesto y los ancestros de Inkarrí
Authors: Urbano Henrique Osvaldo
Published: October 2020

Desde que Arguedas y Roel Pineda publicaron sus versiones de los relatos del ciclo Inkarri, son numerosos los especialistas que se han preocupado por el tema. Pocos, sin embargo, procuraron averiguar en qué medida el héroe, para afirmarse, utiliza esquemas lógicos tradicionales y los transforman para expresar adecuadamente las nuevas situaciones vividas por el runa. En estudios anteriores (Urbano 1974a. 1974b, 1976, 1977, 1980a, 1980b, 1980c), insistí en el hecho de que la tradición andina presenta señales evidentes de cambios profundos. Los héroes contemporáneos recuerdas aún algunos de los gestos de los ancestros precolombinos. Pero el tiempo y el espacio ya no son los mismos y la memoria colectiva sufrió el efecto de las olas sucesivas de misioneros y administradores coloniales.
Marxismo y sociedad andina: derrotero de un malentendido
Authors: Flores Galindo Alberto
Published: October 2020

En la época época de José Carlos Mariátegui era escaso, fragmentario e inseguro el conocimiento sobre las sociedades prehispánicas. Sin embargo Mariátegui consideró imprescindible ocuparse del tema, entre otras ocasiones, al inicio de los 7 Ensayos y en el informe presentado por la delegación peruana a la primera conferencia comunista de Buenos Aires.
Proyecto de declaración americana sobre los derechos de los pueblos indígenas
Authors: Autores Varios
Published: October 2020

Recordando que los pueblos indígenas de las Américas constituyen un segmento organizado, distintivo e integral de su población y tienen derecho a ser parte de la identidad nacional de los países, con un papel especial en el fortalecimiento de las instituciones del Estado y en la realización de la unidad nacional basada en principios democráticos.
Constitución política del Perú
Authors: Perú República del
Published: October 2020

Título 1: De la persona y de la sociedad, capítulo 1: Derechos fundamentales de la persona, artículo 1: La defensa de la persona humana y el respeto de su dignidad son el fin supremo de la sociedad y del Estado.
Reconocimiento de las rondas campesinas
Authors: Perú República del
Published: October 2020

Ley N° 24571 que reconoce a las rondas campesinas, pacíficas, democrácticas y autónomas.
Economía y Ritual en los Condesuyos de Arequipa: Pastores y Tejedores del Siglo XIX
Authors: Millones Santa Gadea Luis
Published: October 2020

El 6 de octubre de 1812, la Regencia del Reino de España, envío al clero de sus colonias peruanas un cuestionario de 36 preguntas, buscando tener una perspectiva más del estado de sus vasallos. El referido documento (A. G. I, Audiencia de Lima, legajo 1598) correspondía al inte´rés en obtener un diagnóstico de los medios humanos con que contaba el gobierno español en los difíciles momentos en que los grupos criollos luchaban abiertamente por el control de las colonias.
Ofrendas de Llamas en la Vida Ceremonial de los Pastores de la puna de Moquegua (Perú) y de la puna de Atacama (Argentina), y consideraciones histórico-culturales sobre la ganadería indígena
Authors: Nachtigall Horst
Published: October 2020

En mi último viaje a Sudamérca (1962), tuve oportunidad de estudiar los rasgos de la vida ceremonial de los criadores de llamas y alpacas que habitan la Puna de Moquegua (Perú) y la Puna de Atacama (Argentina). Se trata de genuinos criadoores de ganado que, además de llamas y alpacas, en la mayoría de los casos crían también ovejas. El ambiente geográfico de estos criadores alcanza generalmente 4,000 metros y más; esto es, está situado siempre demasiado alto para practicar cualquier clase de agricultura. Son grupos sedentarios y habitan en casas rectangulares, con techo a dos aguas, cuyas paredes constan, en parte, de bloques de adobe y, en parte, de piedras no canteadas.
El Apu Ausangate En la Narrativa Popular
Authors: Valderrama Fernández Ricardo , Escalante Gutiérrez Carmen
Published: October 2020

La presente selección de mitos es una muestra de la tradición oral recogida en las comunidades de campesinos y pastores indígenas de las Provincias altas de Cusco y Apurímac. Estos mitos pertenecen a los comuneros de Lauramarca (Cusco) y fueron recogidos durante el año de 1973. Nuestro agradecimiento a Enrique Rosas P. por su colaboración en la traducción.
Lenguaje y gesto ritual en el Sur andino
Authors: Urbano Henrique Osvaldo
Published: October 2020

Durante varios meses del año 1974, reunimos algunas entrevistas en quechua sobre ritos y rituales del Sur andino. Los casos que hoy transcribimos directamente del quechua, forman parte de entrevistas más largas. Seleccionamos solamente algunas partes de la entrevista fijándonos principalmente en cuestiones de vocabulario y gestos rituales.
El ciclo ceremonial anual en el mundo de los Llapuni (Bolivia)
Authors: Albó Xavier
Published: October 2020

Belisario Boeto es una provincia relativamente pequeña, con 15,000 habitantes y una densidad de 8 habitantes por km2. Su capital, Villa Serrano, es el único núcleo importante, con unos 3,000 habitantes. La siguiente población, Mendoza, sólo tiene un centenar de familias. El resto de la población está disperso en unas 170 comunidades pequeñas que, en el mejor de los casos, sólo llegan a tener 30 familias, y en muchos casos no llegan ni a 10. Está en las estribaciones andinas que descienden desde un máximo de 3,840m. hasta los 900 m. en las márgenes del río Grande.