bluuebunny/crossref_metadata_2025 huggingface dataset:
CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate
Authors: Li Bang , Zhao Hui , Tu Zhuchi , Yang Weili , Han Rui , Wang Lu , Luo Xiaopeng , Pan Mingtian , Chen Xiusheng , Zhang Jiawei , Xu Huijuan , Guo Xiangyu , Yan Sen , Yin Peng , Zhao Zhiguang , Liu Jianrong , Luo Yafeng , Li Yuefeng , Yang Zhengyi , Zhang Baogui , Tan Zhiqiang , Xu Hao , Jiang Tianzi , Jiang Yong-hui , Li Shihua , Zhang Yong Q. , Li Xiao-Jiang
Published: March 2023

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to autism symptoms and macrocephaly by a haploinsufficiency mechanism. However, studies of small animal models showed inconsistent findings about the mechanisms for CHD8 deficiency-mediated autism symptoms and macrocephaly. Using the nonhuman primate as a model system, we found that CRISPR/Cas9-mediated CHD8 mutations in the embryos of cynomolgus monkeys led to increased gliogenesis to cause macrocephaly in cynomolgus monkeys. Disrupting CHD8 in the fetal monkey brain prior to gliogenesis increased the number of glial cells in newborn monkeys. Moreover, knocking down CHD8 via CRISPR/Cas9 in organotypic monkey brain slices from newborn monkeys also enhanced the proliferation of glial cells. Our findings suggest that gliogenesis is critical for brain size in primates and that abnormal gliogenesis may contribute to ASD.
Long-term gastrointestinal outcomes of COVID-19
Authors: Xu Evan , Xie Yan , Al-Aly Ziyad
Published: March 2023

A comprehensive evaluation of the risks and 1-year burdens of gastrointestinal disorders in the post-acute phase of COVID-19 is needed but is not yet available. Here we use the US Department of Veterans Affairs national health care databases to build a cohort of 154,068 people with COVID-19, 5,638,795 contemporary controls, and 5,859,621 historical controls to estimate the risks and 1-year burdens of a set of pre-specified incident gastrointestinal outcomes. We show that beyond the first 30 days of infection, people with COVID-19 exhibited increased risks and 1-year burdens of incident gastrointestinal disorders spanning several disease categories including motility disorders, acid related disorders (dyspepsia, gastroesophageal reflux disease, peptic ulcer disease), functional intestinal disorders, acute pancreatitis, hepatic and biliary disease. The risks were evident in people who were not hospitalized during the acute phase of COVID-19 and increased in a graded fashion across the severity spectrum of the acute phase of COVID-19 (non-hospitalized, hospitalized, and admitted to intensive care). The risks were consistent in comparisons including the COVID-19 vs the contemporary control group and COVID-19 vs the historical control group as the referent category. Altogether, our results show that people with SARS-CoV-2 infection are at increased risk of gastrointestinal disorders in the post-acute phase of COVID-19. Post-covid care should involve attention to gastrointestinal health and disease.
Observational evidence for on-shelf heat transport driven by dense water export in the Weddell Sea
Authors: Darelius Elin , Daae Kjersti , Dundas Vår , Fer Ilker , Hellmer Hartmut H. , Janout Markus , Nicholls Keith W. , Sallée Jean-Baptiste , Østerhus Svein
Published: March 2023

The transport of oceanic heat towards the Antarctic continental margin is central to the mass balance of the Antarctic Ice Sheet. Recent modeling efforts challenge our view on where and how the on-shelf heat flux occurs, suggesting that it is largest where dense shelf waters cascade down the continental slope. Here we provide observational evidence supporting this claim. Using records from moored instruments, we link the downslope flow of dense water from the Filchner overflow to upslope and on-shelf flow of warm water.
SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry
Authors: Decaesteker Bieke , Louwagie Amber , Loontiens Siebe , De Vloed Fanny , Bekaert Sarah-Lee , Roels Juliette , Vanhauwaert Suzanne , De Brouwer Sara , Sanders Ellen , Berezovskaya Alla , Denecker Geertrui , D’haene Eva , Van Haver Stéphane , Van Loocke Wouter , Van Dorpe Jo , Creytens David , Van Roy Nadine , Pieters Tim , Van Neste Christophe , Fischer Matthias , Van Vlierberghe Pieter , Roberts Stephen S. , Schulte Johannes , Ek Sara , Versteeg Rogier , Koster Jan , van Nes Johan , Zimmerman Mark , De Preter Katleen , Speleman Frank
Published: March 2023

The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcription factor in adrenergic neuroblastoma based on recurrent chromosome 2p focal gains and amplifications, specific expression in the normal sympatho-adrenal lineage and adrenergic neuroblastoma, regulation by multiple adrenergic specific (super-)enhancers and strong dependency on high SOX11 expression in adrenergic neuroblastomas. SOX11 regulated direct targets include genes implicated in epigenetic control, cytoskeleton and neurodevelopment. Most notably, SOX11 controls chromatin regulatory complexes, including 10 SWI/SNF core components among which SMARCC1, SMARCA4/BRG1 and ARID1A. Additionally, the histone deacetylase HDAC2, PRC1 complex component CBX2, chromatin-modifying enzyme KDM1A/LSD1 and pioneer factor c-MYB are regulated by SOX11. Finally, SOX11 is identified as a core transcription factor of the core regulatory circuitry (CRC) in adrenergic high-risk neuroblastoma with a potential role as epigenetic master regulator upstream of the CRC.
The Arabidopsis endosperm is a temperature-sensing tissue that implements seed thermoinhibition through phyB
Authors: Piskurewicz Urszula , Sentandreu Maria , Iwasaki Mayumi , Glauser Gaëtan , Lopez-Molina Luis
Published: March 2023

Seed thermoinhibition, the repression of germination under high temperatures, prevents seedling establishment under potentially fatal conditions. Thermoinhibition is relevant for phenology and agriculture, particularly in a warming globe. The temperature sensing mechanisms and signaling pathways sustaining thermoinhibition are unknown. Here we show that thermoinhibition in Arabidopsis thaliana is not autonomously controlled by the embryo but is rather implemented by the endosperm. High temperature is sensed through endospermic phyB by accelerating its reversion from the active signaling Pfr form into the inactive Pr form, as previously described in seedlings. This leads to thermoinhibition mediated by PIFs, mainly PIF1, PIF3 and PIF5. Endospermic PIF3 represses the expression of the endospermic ABA catabolic gene CYP707A1 and promotes endospermic ABA accumulation and release towards the embryo to block its growth. Furthermore, endospermic ABA represses embryonic PIF3 accumulation that would otherwise promote embryonic growth. Hence, under high temperatures PIF3 exerts opposite growth responses in the endosperm and embryo.
Optical control of PIEZO1 channels
Authors: Peralta Francisco Andrés , Balcon Mélaine , Martz Adeline , Biljali Deniza , Cevoli Federico , Arnould Benoit , Taly Antoine , Chataigneau Thierry , Grutter Thomas
Published: March 2023

PIEZO proteins are unusually large, mechanically-activated trimeric ion channels. The central pore features structural similarities with the pore of other trimeric ion channels, including purinergic P2X receptors, for which optical control of channel gating has been previously achieved with photoswitchable azobenzenes. Extension of these chemical optogenetics methods to mechanically-activated ion channels would provide tools for specific manipulation of pore activity alternative to non-specific mechanical stimulations. Here we report a light-gated mouse PIEZO1 channel, in which an azobenzene-based photoswitch covalently tethered to an engineered cysteine, Y2464C, localized at the extracellular apex of the transmembrane helix 38, rapidly triggers channel gating upon 365-nm-light irradiation. We provide evidence that this light-gated channel recapitulates mechanically-activated PIEZO1 functional properties, and show that light-induced molecular motions are similar to those evoked mechanically. These results push the limits of azobenzene-based methods to unusually large ion channels and provide a simple stimulation means to specifically interrogate PIEZO1 function.
An Online Mammography Database with Biopsy Confirmed Types
Authors: Cai Hongmin , Wang Jinhua , Dan Tingting , Li Jiao , Fan Zhihao , Yi Weiting , Cui Chunyan , Jiang Xinhua , Li Li
Published: March 2023

Breast carcinoma is the second largest cancer in the world among women. Early detection of breast cancer has been shown to increase the survival rate, thereby significantly increasing patients’ lifespan. Mammography, a noninvasive imaging tool with low cost, is widely used to diagnose breast disease at an early stage due to its high sensitivity. Although some public mammography datasets are useful, there is still a lack of open access datasets that expand beyond the white population as well as missing biopsy confirmation or with unknown molecular subtypes. To fill this gap, we build a database containing two online breast mammographies. The dataset named by Chinese Mammography Database (CMMD) contains 3712 mammographies involved 1775 patients, which is divided into two branches. The first dataset CMMD1 contains 1026 cases (2214 mammographies) with biopsy confirmed type of benign or malignant tumors. The second dataset CMMD2 includes 1498 mammographies for 749 patients with known molecular subtypes. Our database is constructed to enrich the diversity of mammography data and promote the development of relevant fields.
Blue-light background impairs visual exogenous attention shift
Authors: Yang Chien-Chun , Tsujimura Sei-ichi , Yeh Su-Ling
Published: March 2023

Previous research into the effects of blue light on visual-spatial attention has yielded mixed results due to a lack of properly controlling critical factors like S-cone stimulation, ipRGCs stimulation, and color. We adopted the clock paradigm and systematically manipulated these factors to see how blue light impacts the speed of exogenous and endogenous attention shifts. Experiments 1 and 2 revealed that, relative to the control light, exposure to the blue-light background decreased the speed of exogenous (but not endogenous) attention shift to external stimuli. To further clarify the contribution(s) of blue-light sensitive photoreceptors (i.e., S-cone and ipRGCs), we used a multi-primary system that could manipulate the stimulation of a single type of photoreceptor without changing the stimulation of other photoreceptors (i.e., the silent substitution method). Experiments 3 and 4 revealed that stimulation of S-cones and ipRGCs did not contribute to the impairment of exogenous attention shift. Our findings suggest that associations with blue colors, such as the concept of blue light hazard, cause exogenous attention shift impairment. Some of the previously documented blue-light effects on cognitive performances need to be reevaluated and reconsidered in light of our findings.
Subsistence of early anatomically modern humans in Europe as evidenced in the Protoaurignacian occupations of Fumane Cave, Italy
Authors: Marín-Arroyo Ana B. , Terlato Gabriele , Vidal-Cordasco Marco , Peresani Marco
Published: March 2023

Documenting the subsistence strategies developed by early modern humans is relevant for understanding the success of their dispersal throughout Eurasia. Today, we know that there was not a single colonization event and that the process was progressive while coping with the MIS3 abrupt climatic oscillations. Modern humans expanded into the continent by adapting to different topographic situations and by exploiting resources in diverse ecological niches. The northern part of Italy is one of the first European regions where early modern humans are documented. Here, we present the subsistence regimen adopted by the Protoaurignacian groups in two different levels in Fumane Cave based on archaeozoological data. New radiocarbon dates confirm an overlap between Uluzzian and Protoaurignacian occupations, around 42 and 41,000 cal BP, and reveal that modern humans occupied the cave from GI10 to GS9, the last level coinciding with the Heinrich Event 4. The data indicate seasonal site occupations during late spring/summer and that prey exploitation was focused mostly on ibex and chamois, killed in nearby areas. The whole faunal assemblage suggests the presence of early modern humans in a cold environment with mostly open landscapes and patchy woodlands. The estimation of net primary productivity (NPP) in Fumane, compared with other contemporaneous Italian sites, reflects how the NPP fluctuations in the Prealpine area, where Fumane is located, affected the biotic resources in contrast to known Mediterranean sites. From a pan-European perspective, the spatiotemporal fluctuation of the NPP versus the subsistence strategies adopted by Protoaurignacian groups in the continent supports rapid Homo sapiens dispersal and resilience in a mosaic of environments that were affected by significant climate changes.
Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib
Authors: Till Kathleen J. , Abdullah Mariah , Alnassfan Tahera , Janet Gallardo Zapata , Marks Thomas , Coma Silvia , Weaver David T. , Pachter Jonathan A. , Pettitt Andrew R. , Slupsky Joseph R.
Published: March 2023

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma that is incurable with existing therapies, and therefore presents a significant unmet clinical need. The ability of this disease to overcome therapy, including those that target the B cell receptor pathway which has a pathogenic role in MCL, highlights the need to develop new treatment strategies. Herein, we demonstrate that a distinguishing feature of lymph node resident MCL cells is the expression of phosphatidylinositol 3-kinase γ (PI3Kγ), a PI3K isoform that is not highly expressed in other B cells or B-cell malignancies. By exploring the role of PI3K in MCL using different PI3K isoform inhibitors, we provide evidence that duvelisib, a dual PI3Kδ/γ inhibitor, has a greater effect than PI3Kδ- and PI3Kγ-selective inhibitors in blocking the proliferation of primary MCL cells and MCL cell lines, and in inhibiting tumour growth in a mouse xenograft model. In addition, we demonstrated that PI3Kδ/γ signalling is critical for migration of primary MCL cells and cell lines. Our data indicates that aberrant expression of PI3Kγ is a critical feature of MCL pathogenesis. Thus, we suggest that the dual PI3Kδ/γ duvelisib would be effective for the treatment of mantle cell lymphoma.
Smoking-induced subgingival dysbiosis precedes clinical signs of periodontal disease
Authors: Tamashiro Ryan , Strange Leah , Schnackenberg Kristin , Santos Janelle , Gadalla Hana , Zhao Lisa , Li Eric C. , Hill Emilie , Hill Brett , Sidhu Gurjit S. , Kirst Mariana , Walker Clay , Wang Gary P.
Published: March 2023

Smoking accelerates periodontal disease and alters the subgingival microbiome. However, the relationship between smoking-associated subgingival dysbiosis and progression of periodontal disease is not well understood. Here, we sampled 233 subgingival sites longitudinally from 8 smokers and 9 non-smokers over 6–12 months, analyzing 804 subgingival plaque samples using 16 rRNA sequencing. At equal probing depths, the microbial richness and diversity of the subgingival microbiome was higher in smokers compared to non-smokers, but these differences decreased as probing depths increased. The overall subgingival microbiome of smokers differed significantly from non-smokers at equal probing depths, which was characterized by colonization of novel minority microbes and a shift in abundant members of the microbiome to resemble periodontally diseased communities enriched with pathogenic bacteria. Temporal analysis showed that microbiome in shallow sites were less stable than deeper sites, but temporal stability of the microbiome was not significantly affected by smoking status or scaling and root planing. We identified 7 taxa—Olsenella sp., Streptococcus cristatus, Streptococcus pneumoniae, Streptococcus parasanguinis, Prevotella sp., Alloprevotella sp., and a Bacteroidales sp. that were significantly associated with progression of periodontal disease. Taken together, these results suggest that subgingival dysbiosis in smokers precedes clinical signs of periodontal disease, and support the hypothesis that smoking accelerates subgingival dysbiosis to facilitate periodontal disease progression.
Emotion recognition based on group phase locking value using convolutional neural network
Authors: Cui Gaochao , Li Xueyuan , Touyama Hideaki
Published: March 2023

Electroencephalography (EEG)-based emotion recognition is an important technology for human–computer interactions. In the field of neuromarketing, emotion recognition based on group EEG can be used to analyze the emotional states of multiple users. Previous emotion recognition experiments have been based on individual EEGs; therefore, it is difficult to use them for estimating the emotional states of multiple users. The purpose of this study is to find a data processing method that can improve the efficiency of emotion recognition. In this study, the DEAP dataset was used, which comprises EEG signals of 32 participants that were recorded as they watched 40 videos with different emotional themes. This study compared emotion recognition accuracy based on individual and group EEGs using the proposed convolutional neural network model. Based on this study, we can see that the differences of phase locking value (PLV) exist in different EEG frequency bands when subjects are in different emotional states. The results showed that an emotion recognition accuracy of up to 85% can be obtained for group EEG data by using the proposed model. It means that using group EEG data can effectively improve the efficiency of emotion recognition. Moreover, the significant emotion recognition accuracy for multiple users achieved in this study can contribute to research on handling group human emotional states.
Hydrological controls on base metal precipitation and zoning at the porphyry-epithermal transition constrained by numerical modeling
Authors: Stoltnow Malte , Weis Philipp , Korges Maximilian
Published: March 2023

Ore precipitation in porphyry copper systems is generally characterized by metal zoning (Cu–Mo to Zn–Pb–Ag), which is suggested to be variably related to solubility decreases during fluid cooling, fluid-rock interactions, partitioning during fluid phase separation and mixing with external fluids. Here, we present new advances of a numerical process model by considering published constraints on the temperature- and salinity-dependent solubility of Cu, Pb and Zn in the ore fluid. We quantitatively investigate the roles of vapor-brine separation, halite saturation, initial metal contents, fluid mixing and remobilization as first-order controls of the physical hydrology on ore formation. The results show that the magmatic vapor and brine phases ascend with different residence times but as miscible fluid mixtures, with salinity increases generating metal-undersaturated bulk fluids. The release rates of magmatic fluids affect the location of the thermohaline fronts, leading to contrasting mechanisms for ore precipitation: higher rates result in halite saturation without significant metal zoning, lower rates produce zoned ore shells due to mixing with meteoric water. Varying metal contents can affect the order of the final metal precipitation sequence. Redissolution of precipitated metals results in zoned ore shell patterns in more peripheral locations and also decouples halite saturation from ore precipitation.
Release of sterile Aedes aegypti mosquitoes: chilling effect on mass-reared males survival and escape ability and on irradiated males sexual competitiveness
Authors: Sánchez-Aldana-Sánchez Génesis Alejandra , Liedo Pablo , Bond J. Guillermo , Dor Ariane
Published: March 2023

In the sterile insect technique, it is important to measure the impact of mass-rearing and handling of sterile males to allow a successful control of the target wild population. This study evaluates the effect of pre-release chilling on the survival, escape ability, and sexual competitiveness of male Aedes aegypti. To determine survival and escape ability, mosquitoes were chilled at 4 °C using four different treatments of either one exposure (25 min) or two consecutive exposures (25 + 25 min, 25 + 50 min, 25 + 100 min). For sexual competitiveness, two different treatments were evaluated, chilling for 25 min once and twice. Results showed that the longest exposure to chilling caused a significant reduction of survival time, from 67 to 54 days. Escape ability was reduced by the first chilling from 25 to 7% and with the second chilling, it was reduced from 30 to 24% in the control to 4.9, 2.0 and 0.5% for 25, 50 and 100 min, respectively. Sexual competitiveness index was reduced from 1.16 in the control, to 0.32 and − 0.11 for treatments involving one and two chilling periods, respectively. It is recommended to increase the chilling temperature and reduce the exposure time to reduce the harmful effects on sterile males.
EHR foundation models improve robustness in the presence of temporal distribution shift
Authors: Guo Lin Lawrence , Steinberg Ethan , Fleming Scott Lanyon , Posada Jose , Lemmon Joshua , Pfohl Stephen R. , Shah Nigam , Fries Jason , Sung Lillian
Published: March 2023

Temporal distribution shift negatively impacts the performance of clinical prediction models over time. Pretraining foundation models using self-supervised learning on electronic health records (EHR) may be effective in acquiring informative global patterns that can improve the robustness of task-specific models. The objective was to evaluate the utility of EHR foundation models in improving the in-distribution (ID) and out-of-distribution (OOD) performance of clinical prediction models. Transformer- and gated recurrent unit-based foundation models were pretrained on EHR of up to 1.8 M patients (382 M coded events) collected within pre-determined year groups (e.g., 2009–2012) and were subsequently used to construct patient representations for patients admitted to inpatient units. These representations were used to train logistic regression models to predict hospital mortality, long length of stay, 30-day readmission, and ICU admission. We compared our EHR foundation models with baseline logistic regression models learned on count-based representations (count-LR) in ID and OOD year groups. Performance was measured using area-under-the-receiver-operating-characteristic curve (AUROC), area-under-the-precision-recall curve, and absolute calibration error. Both transformer and recurrent-based foundation models generally showed better ID and OOD discrimination relative to count-LR and often exhibited less decay in tasks where there is observable degradation of discrimination performance (average AUROC decay of 3% for transformer-based foundation model vs. 7% for count-LR after 5–9 years). In addition, the performance and robustness of transformer-based foundation models continued to improve as pretraining set size increased. These results suggest that pretraining EHR foundation models at scale is a useful approach for developing clinical prediction models that perform well in the presence of temporal distribution shift.
The ratio of TAPSE to PASP predicts prognosis in lung transplant candidates with pulmonary arterial hypertension
Authors: Ishii Satoshi , Minatsuki Shun , Hatano Masaru , Saito Akihito , Yagi Hiroki , Shimbo Mai , Soma Katsura , Fujiwara Takayuki , Itoh Hidetaka , Konoeda Chihiro , Sato Masaaki , Takeda Norifumi , Daimon Masao , Nakajima Jun , Komuro Issei
Published: March 2023

Lung transplantation (LT) is the only option for patients with pulmonary arterial hypertension (PAH) refractory to maximal medical therapy. However, some patients referred for LT could survive without LT, and its determinants remain unclear. This study aimed to elucidate prognostic factors of severe PAH at the referral time. We retrospectively analyzed 34 patients referred for LT evaluation. The primary outcome was a composite of death or LT. Over a median follow-up period of 2.56 years, eight patients received LT and eight died. Compared with LT-free survival group, pulmonary arterial systolic pressure (PASP) was higher (p = 0.042), and the ratio of tricuspid annular plane systolic excursion (TAPSE) to PASP (TAPSE/PASP) was lower (p = 0.01) in LT or death group. In receiver operating characteristic analysis, the area under the curve was 0.759 (95% confidence interval 0.589–0.929) for TAPSE/PASP to predict primary outcome, and the optimal cut-off value was 0.30 mm/mmHg (sensitivity 0.875 and specificity 0.667). In a multivariate analysis, TAPSE/PASP was independently associated with death or LT. Kaplan–Meier analysis showed a better LT-free survival in patients with TAPSE/PASP ≧0.30 mm/mmHg than in those with < 0.30 mm/mmHg (p = 0.001). Low-level TAPSE/PASP could be a poor prognostic factor in PAH patients referred for LT evaluation.
A Pleistocene origin of the strandflat coastal platform in southwestern Scandinavia
Authors: Fossen Haakon
Published: March 2023

An impressively extensive shore platform, the strandflat, is cut 20–50 km into hard crystalline bedrock along most of the Norwegian coastline. Its age and origin have been debated for more than a century, including a model that it represents a weathered, buried and re-exposed Triassic surface. Resolving this issue requires integrated examination of the coastal area together with the offshore Mesozoic rift margin. Here I combine new 3D broadband seismic, bathymetric, and onshore elevation data along coastal West Norway and find that the near-horizontal strandflat postdates both the west-sloping onshore “paleic” surface and the offshore Jurassic denudation surface. It also postdates tilted North Sea Neogene sediments. Consistent with low-temperature thermochronologic data, this shows that the strandflat is a Pleistocene geomorphic feature formed through periods of varying climatic conditions, facilitated by preexisting fault and fracture zones. It is not part of an inherited Mesozoic landscape.
Binary to ternary drug–drug molecular adducts of the antihypertensive drug ketanserin (KTS) with advanced physicochemical properties
Authors: Rout Smruti Rekha , Kenguva Gowtham , Giri Lopamudra , Kar Ananya , Dandela Rambabu
Published: March 2023

Focusing on a reliable supramolecular synthon approach, novel binary and ternary molecular adducts of the antihypertensive drug ketanserin (KTS) with diverse aromatic carboxylic acid derivatives are reported.
Enhanced hydrogen evolution activity of CsPbBr3 nanocrystals achieved by dimensionality change
Authors: Guo Qing , Zhang Jin-Dan , Chen Ya-Jing , Zhang Ke-Yuan , Guo Li-Na , Shan Qi-Chao , Lu Jun-Lin , Duan Xin-Hua , Wu Li-Zhu
Published: March 2023

In terms of facilitated photogenerated charge carrier dynamics and induced proton reduction potential, photocatalytic H2 evolution could be improved by dimensionality tuning from 3D nanocubes to 1D nanorods.
Single-cell-array biomass-templated architecture of hierarchical porous electrocatalysts for Zn–air and Zn–H2O2 batteries
Authors: Zhu Zhenjiang , Jin Liangyu , Zhou Meng , Fu Kui , Meng Fancheng , Wei Xiangfeng , Liu Jiehua
Published: March 2023

Hierarchical macro–meso–microporous ZIF-67/nori-derived electrocatalysts were synthesized using single-cell-layered biomass, and yielded a maximum power density of 476 mW cm−2 in a Zn–H2O2 battery.
To dimerize or not:para-aminothiophenol on a bismuth heterostructure
Authors: Bhadoria Poonam , Saroj Arti , Ramanathan Venkatnarayan
Published: March 2023

Surface enhanced Raman spectroscopy (SERS) ofp-aminothiophenol (PATP) was investigated on β-Bi2O3/Bi2O2CO3nanoparticles, a novel bismuth based metal substrate with the lowest limit of detection of 1 mM.
Chiral symmetry breaking induced by energy dissipation
Authors: Arango-Restrepo A. , Arteaga O. , Barragán D. , Rubi J. M.
Published: March 2023

Formation of l and d-enantiomers. In dissipative conditions (red symbols), there is a disparity in the energy landscapes leading to different enantiomer proportions, PD > PL. At equilibrium, without dissipation, PD = PL.
Construction and engineering of an interfacial structure in a Cux/FeMgOy catalyst for the photoreduction of CO2 to ethylene
Authors: Yu He , Fu Baoai , Fu Fengzhi , Zhu Yanfei , Liu Yanan , Feng Junting , Li Dianqing
Published: March 2023

An FeMgOy-modified Cu interfacial structure is constructed as a photocatalyst for CO2 conversion with H2O via the structural topological transformation of layered double hydroxides.
Using a diphenyl-bi-(1,2,4-triazole) tricarbonylrhenium(i) complex with intramolecular π–π stacking interaction for efficient solid-state luminescence enhancement
Authors: Poirot Alexandre , Vanucci-Bacqué Corinne , Delavaux-Nicot Béatrice , Meslien Clarisse , Saffon-Merceron Nathalie , Serpentini Charles-Louis , Bedos-Belval Florence , Benoist Eric , Fery-Forgues Suzanne
Published: March 2023

The intramolecular π–π stacking interactions due to a minimalist ligand enhance the rigidity of the Re-BPTA complex,thus promoting remarkable solid-state luminescence properties.
Punicalagin protects against impaired skeletal muscle function in high-fat-diet-induced obese mice by regulating TET2
Authors: Meng Xiangyuan , Tian Chunyan , Xie Chenqi , Zhang Hao , Wang Haoyu , Zhang Mai , Lu Zhenquan , Li Duo , Chen Lei , Gao Tianlin
Published: March 2023

Punicalagin supplementation protects against obesity-induced impairment of the skeletal muscle function via regulating the protein stability of TET2 and the enzymatic activity of TET2 demethylation.
Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity
Authors: Juhng Seorin , Song Jieun , You Jeongyun , Park Jihyun , Yang Huisuk , Jang Mingyu , Kang Geonwoo , Shin Jiwoo , Ko Hyuk Wan , Jung Hyungil
Published: March 2023

The triple layer system (TLM) is a novel three layer composition dissolving microneedle which enhances drug efficacy and bioavailability, where each layer is designed to maximize the microneedle insertion and drug delivery.
Measurement of cellular thermal properties and their temperature dependence based on frequency spectra via an on-chip-integrated microthermistor
Authors: Inomata Naoki , Miyamoto Takumi , Okabe Kohki , Ono Takahito
Published: March 2023

The thermal properties of cells were determined to depend on both temperatures and local heating frequencies using on-chip-integrated microthermistors.
C3N2: the missing part of highly stable porous graphitic carbon nitride semiconductors
Authors: Cai Xinyong , Chen Jiao , Wang Hongyan , Ni Yuxiang , Chen Yuanzheng , King R. Bruce
Published: March 2023

With two suitable organic units (TAPA and HADQ), H-C3N2 and T-C3N2 are designed and proposed based on the high possibility for experimental realization. They show different structural features and exceptional optoelectronic properties.
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems
Authors: Jeandet Philippe , Uddin Md. Sahab , Clément Christophe , Aziz Aziz , Jacquard Cédric , Khan Haroon , Shah Muhammad Ajmal , Barka Essaid Ait , Koffas Mattheos , Nabavi Seyed Mohammad , Sobarzo-Sánchez Eduardo , Renault Jean-Hugues
Published: March 2023

Extraordinary progress has been made over the past decade in the chemical synthesis of many stilbene oligomers (>2) as well as in biotechnological methods for the production of these compounds.
Labeling approaches for DNA-PAINT super-resolution imaging
Authors: Banerjee Abhinav , Anand Micky , Ganji Mahipal
Published: March 2023

DNA-PAINT imaging crucially depends on efficient labeling probes, and this article presents a comprehensive coverage on the variety of binders, various labelling chemistries, and DNA sequence pairs employed for its implementation.
Silver-catalyzed cyclization of α-imino-oxy acids to fused tetralone derivatives
Authors: Liu Kai , Li Feng , Wang Jingjing , Zhang Zhaowei , Du Fengge , Su Hanxiao , Wang Yonghong , Yuan Qingqing , Li Fei , Wang Teng
Published: March 2023

A silver-catalyzed cyclization of α-imino-oxy acids under mild conditions has been described. This reaction offers facile access to a diverse range of fused tetralone derivatives with exquisite stereoselectivity in moderate to good yields.
Simultaneous precipitation and discharge plasma processing for one-step synthesis of α-Fe2O3–Fe3O4/graphene visible light magnetically separable photocatalysts
Authors: Tuyen Nguyen Long , Toan Tran Quoc , Hung Nguyen Ba , Trieu Pham Quoc , Dinh Nguyen Ngoc , Do Danh Bich , Van Thanh Dang , Nguyen Van-Truong
Published: March 2023

A novel facile combination of precipitation and plasma discharge reaction is successfully employed for one-step synthesis of an α-Fe2O3–Fe3O4graphene nanocomposite (GFs).
Highly stretchable ionotronic pressure sensors with broad response range enabled by microstructured ionogel electrodes
Authors: Huang Zhenkai , Chen Yutong , Peng Jianping , Huang Tianrui , Hu Faqi , Liu Xiang , Xu Liguo , Yue Kan
Published: March 2023

An ionotronic capacitive pressure sensor synergistically combines microstructured ionogel electrodes and a contact area-controlled sensing mechanism, demonstrating high sensitivity, durability and stretchability, broad pressure range, and simple fabrication process.
Achieving ultralong directional liquid transportation spontaneously with a high velocity
Authors: Liu Qiankai , Zhang Jie , Sun Pengcheng , Wang Jianping , Zhao Wei , Zhao Guolong , Chen Ni , Yang Yinfei , Li Liang , He Ning , Wang Zuankai , Hao Xiuqing
Published: March 2023

Ultralong and high velocity drop transportation is achieved through the combination of gradient hydrophobic backgrounds and cascaded super-hydrophilic divergent channels.
Recent advances in the synthesis of chiral α-tertiary aminesviatransition-metal catalysis
Authors: Xu Yongzhuo , Wang Jiajia , Deng Guo-Jun , Shao Wen
Published: March 2023

Recent progress in the assembly of chiral α-tertiary amines in the last decadeviatransition-metal catalysis is summarized.
Aromaticity in P8 allotropes and (CH)8 analogues: significance of their 40 valence electrons?
Authors: Attia Amr A.A. , Muñoz-Castro Alvaro , Lupan Alexandru , King R. Bruce
Published: March 2023

The lowest energy P8 structure is a cuneane analogue with no PP double bonds. Higher energy P8 structures are polycyclic systems with at most a single PP double bond. The lowest energy (CH)8 structure is cyclooctatetraene. Cubane isomers are very high energy structures.
Halogen bonds with carbenes acting as Lewis base units: complexes of imidazol-2-ylidene: theoretical analysis and experimental evidence
Authors: Grabowski Sławomir J.
Published: March 2023

Complexes of imidazol-2-ylidene with X2, HCCX and XCN (X is a halogen centre) are linked by halogen bonds which possess a partly covalent character. In extreme cases of X2 complexes the halonium cation transfer to the Lewis base is observed.
Tb3+-based multi-mode optical ratiometric thermometry
Authors: Zhang Zixuan , Li Fei , Yang Yuanbo , Wang Zhijun , Li Panlai , Zhang Rongxiang , Suo Hao , Li Leipeng
Published: March 2023

Luminescence intensity ratio and single-band ratiometric thermometries have been achieved in one material.
Protonation of serine: conformers, proton affinities and gas-phase basicities at the “gold standard” and beyond
Authors: Nacsa András B. , Kígyósi Máté , Czakó Gábor
Published: March 2023

Proton affinities and gas-phase basicities of amino acid serine are determined using a comprehensive conformational search for the neutral and protonated species and a coupled-cluster-based high-level composite ab initio approach.
Festschrift for Wolfgang E. Ernst – electronic and nuclear dynamics and their interplay in molecules, clusters and on surfaces
Authors: Hauser Andreas W. , Havenith Martina , Koch Markus , Sterrer Martin
Published: March 2023

Guest editors, Andreas W. Hauser, Martina Havenith, Markus Koch and Martin Sterrer, introduce this themed issue dedicated to Professor Wolfgang E. Ernst on the occasion of his 70th birthday.
Dynamically reversible cooperation and interaction of multiple rotating micromotors
Authors: Zhu Shilu , Cheng Yifan , Chen Jialong , Liu Guangli , Luo Tingting , Yang Runhuai
Published: March 2023

A microsystem composed of multiple rotating micromotors can achieve reversible transformation between cooperative and interactive modes, and dynamic behaviours of self-organization are realized based on the microsystem.
Correction: Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring
Authors: Marrero Denise , Guimera Anton , Maes Laure , Villa Rosa , Alvarez Mar , Illa Xavi
Published: March 2023

Correction for ‘Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring’ by Denise Marrero et al., Lab Chip, 2023, https://doi.org/10.1039/d2lc01097f.
Nanocomposite conductive hydrogels with Robust elasticity and multifunctional responsiveness for flexible sensing and wound monitoring
Authors: Shen Kaixiang , Liu Zheng , Xie Ruilin , Zhang Yuchen , Yang Yuxuan , Zhao Xiaodan , Zhang Yanfeng , Yang Aimin , Cheng Yilong
Published: March 2023

An ultradurable conductive hydrogel is designedviaradical polymerization of APBA and AM in the presence of XLG-stabilized CNTs. The hydrogel can monitor various human motions and exhibit vast potential in sensing and pro-healing of skin wounds.
Correction: Tuning the arrangement of lamellar nanostructures: achieving the dual function of physically killing bacteria and promoting osteogenesis
Authors: Mo Shi , Tang Kaiwei , Liao Qing , Xie Lingxia , Wu Yuzheng , Wang Guomin , Ruan Qingdong , Gao Ang , Lv Yuanliang , Cai Kaiyong , Tong Liping , Wu Zhengwei , Chu Paul K , Wang Huaiyu
Published: March 2023

Correction for ‘Tuning the arrangement of lamellar nanostructures: achieving the dual function of physically killing bacteria and promoting osteogenesis’ by Shi Mo et al., Mater. Horiz., 2023, 10, 881–888, https://doi.org/10.1039/d2mh01147f.
CuIIporphyrin-mediated M–N–C single- and dual-metal catalysts for efficient NO3− electrochemical reduction
Authors: Shi XinXing , Li Minzhi , Liang Xu , Zhu Weihua , Chen Zhilin
Published: March 2023

Herein, a series of Cu–N–C-type catalysts was prepared and characterized by high-temperature annealing of CuIItetrephenylporphyrin (CuIITPP)-coated reduced graphene oxide (rGO).
Characterization and isolation of an 18-crown-6 complex of potassium hydroxide prepared by milling: application to mechanochemical organic synthesis
Authors: Vugrin Leonarda , Halasz Ivan , Geneste Hervé
Published: March 2023

Solid-state supramolecular complexation of potassium cations enables the reactivity of KOH in mechanochemical organic reactions.
SnSe quantum dots anchored on few-layered Ti3C2 as anodes for sodium ion batteries with enhanced cycling stability
Authors: Ni Guoxu , Zhang Yingjie , Li Yuzheng , Xu Chengxiao , Zhang Jinjie , Huo Peipei , Liu Bo
Published: March 2023

0D SnSe quantum dots are uniformly distributed on 2D MXene nanosheets to enhance the cycling stability of sodium-ion batteries.
pH/ROS-responsive propelled nanomotors for the active treatment of renal injury
Authors: Tong Fei , Liu Jin , Luo Lei , Qiao Lingyan , Wu Jianming , Wu Guosheng , Mei Qibing
Published: March 2023

H2S nanomotors show potential for the active treatment of AKI.
Alternatives to water oxidation in the photocatalytic water splitting reaction for solar hydrogen production
Authors: Wu Yaqiang , Sakurai Takuya , Adachi Takumi , Wang Qian
Published: March 2023

We summarize how various photo-oxidation reactions, rather than water oxidation, can be integrated with proton reduction in photocatalysis to generate H2while producing valuable chemicals for a sustainable chemical industry and eliminating waste.
A potent fluorescent transmembrane HCl transporter perturbs cellular pH and promotes cancer cell death
Authors: Fares Mohamed , Wu Xin , McNaughton Daniel A. , Gilchrist Alexander M. , Lewis William , Keller Paul A. , Arias-Betancur Alain , Fontova Pere , Pérez-Tomás Ricardo , Gale Philip A.
Published: March 2023

A series of fluorescent coumarin-based bis-ureas have been synthesised. These compounds show strong HCl cotransport properties in model vesicle systems. Cellular localisation studies show that cytotoxic compound 4 localises in lysosomes and perturbs cellular pH.
Synthesis and conformational preferences of peptides and proteins with cysteine sulfonic acid
Authors: Bhatt Megh R. , Zondlo Neal J.
Published: March 2023

A new method for the oxidation of cysteine to its sulfonic acid was developed. In peptides and proteins, cysteine sulfonic acid exhibits a strong propensity for side chain–main chain sulfonate–amide hydrogen bonds.
Recent progress in polyoxometalate–viologen photochromic hybrids: structural design, photochromic mechanism, and applications
Authors: Li Li , Yu Yang-Tao , Hua Yang , Li Xiao-Nan , Zhang Hong
Published: March 2023

Polyoxometalate–viologen hybrids are reviewed, including structural design, competing electron transfer process, and new knowledge on photochromic mechanisms and their applications.
Merging Ullmann-type cyclization and ring-expansion: a facile assembly of pyrimidine-fused quinazolinones by copper catalysis
Authors: Sun Zhen-Wei , Luo Na , Zhang Xiang , Tuo Wen-Jun , Hu Xiao-Qiang , Jia Feng-Cheng
Published: March 2023

A copper-catalyzed tandem cyclization reaction of readily available 4-bromoisatins and amidine hydrochlorides has been developed for the first time, enabling the efficient synthesis of pyrimidoquinazolinones in useful yields.
Detection of emotional and behavioural changes after traumatic brain injury: A comprehensive survey
Authors: Vutakuri Neha
Published: March 2023

Traumatic brain injury (TBI) can affect normal brain function and may be caused by a vehicle accident, falling, and so on. The purpose of this survey is to provide clear knowledge of TBI, the causes of TBI, the impacts of TBI, and the role of family members and friends in recovery. TBI affects the daily life of the patients, both physically and mentally. After TBI, the patients may experience many emotional and behavioural changes because of a lack of certain brain functions. These changes affect their personal and social relationships. On the other hand, these changes depend on the severity of the TBI (i.e. mild, moderate, or severe), which is measured using the Glasgow coma score. Generally, three processes are used for emotion recognition: preprocessing, feature extraction, and emotion recognition. Preprocessing is performed for landmark detection and pose normalisation, which improves the performance of emotion detection. Feature extraction and emotion recognition are performed by various deep learning techniques, such as convolution neural networks and long short‐term memory. These techniques recognise the behavioural and emotional changes (depression, anxiety, anger, personality changes etc.) of TBI patients using facial expressions. Family members and friends play an important role in TBI patients' recovery, the extent of which is based on the severity of the TBI. The care of family members and friends leads to quick recovery and rehabilitation of patients from TBI. Finally, testing is performed using Computed Tomography images, Magnetic Resonance Imaging images, Electroencephalography signals, and patient demographics, which together show that the deep learning methods achieve better performance in terms of accuracy, precision, recall, and F‐measure in recognising emotional and behavioural changes after TBI. The authors conclude with a summary of the future of emotional and behavioural change prediction methods for TBI patients.
Design of 60 GHz millimeter‐wave SIW antenna for 5G WLAN/WPAN applications
Authors: Al Soufy Khaled A. , Al‐ashwal Nagi H. , Swillam M. A. , Al‐Kamali Faisal S. , D'Amours Claude , Marish Essa M. , Alnajjar Ali N.
Published: March 2023

Broadband millimeter Wave (mmWave) transmission at the 60 GHz band is a great prospect to meet the demanding high data rate requirements of future wireless personal area network (WPAN) and wireless local area network (WLAN) 5G networks. This paper proposes a single layer H‐plane sectoral horn mmWave antenna at 60 GHz using substrate integrated waveguide (SIW) technology for the future high‐speed short range WPAN and WLAN networks. The benefits of the proposed antenna are high gain, low cost, small size, and ease of integration with other planar circuits. The proposed SIW horn is constructed with RT/duroid 5880 substrate, which has a relative permittivity and loss tangent with a thickness of 0.508 mm. The novelty of this work is; a wider bandwidth is achieved by adding striplines at the horn aperture to match the antenna with air and to increase the antenna operating bandwidth. In addition, the antenna gain is improved by adding a dielectric lens with the striplines at the radiating end. During these steps, the antenna parameters are tuned and optimized to achieve the best results as compared to related previous studies. The proposed antenna's performance is analyzed in terms of gain, return loss (S11) and radiation pattern at a frequency of 60 GHz. Simulation results are carried out by using industry standard software, Computer Simulation Technology (CST) microwave studio. The designed antenna achieves a peak gain of 13 dB and impedance bandwidth when , 8.6 GHz (13.688%) for the reflection coefficient of . The results show that the proposed antenna achieves stable tunable 60 GHz frequency performance, which makes it feasible to deploy in WLAN/WPAN operating in mmWave bands.
DSGEM: Dual scene graph enhancement module‐based visual question answering
Authors: Wang Boyue , Ma Yujian , Li Xiaoyan , Liu Heng , Hu Yongli , Yin Baocai
Published: March 2023

Visual Question Answering (VQA) aims to appropriately answer a text question by understanding the image content. Attention‐based VQA models mine the implicit relationships between objects according to the feature similarity, which neglects the explicit relationships between objects, for example, the relative position. Most Visual Scene Graph‐based VQA models exploit the relative positions or visual relationships between objects to construct the visual scene graph, while they suffer from the semantic insufficiency of visual edge relations. Besides, the scene graph of text modality is often ignored in these works. In this article, a novel Dual Scene Graph Enhancement Module (DSGEM) is proposed that exploits the relevant external knowledge to simultaneously construct two interpretable scene graph structures of image and text modalities, which makes the reasoning process more logical and precise. Specifically, the authors respectively build the visual and textual scene graphs with the help of commonsense knowledge and syntactic structure, which explicitly endows the specific semantics to each edge relation. Then, two scene graph enhancement modules are proposed to propagate the involved external and structural knowledge to explicitly guide the feature interaction between objects (nodes). Finally, the authors embed such two scene graph enhancement modules to existing VQA models to introduce the explicit relation reasoning ability. Experimental results on both VQA V2 and OK‐VQA datasets show that the proposed DSGEM is effective and compatible to various VQA architectures.