bluuebunny/crossref_metadata_2025 huggingface dataset:
Common in atherogenesis and carcinogenesis: clonal hematopoiesis
Authors: Sleptsov A. A. , Nazarenko M. S. , Puzyrev V. Р.
Published: November 2023

Clonal hematopoiesis is a common age-dependent state accompanied by the expansion of mutant hematopoietic stem cells as a result of somatic mutations and is associated with a high risk of hematopoietic neoplasms and cardiovascular diseases. Clonal hematopoiesis in human ontogenesis occurs asymptomatically, and the fraction of mutant clones can exceed more than 2% of the total pool of circulating nucleated blood cells by age 70. Due to the variability of the accumulation rate of mutant clones, signs of clonal hematopoiesis can be observed at a younger age. Clonal hematopoiesis may act as a benign, precancerous condition and a strong factor for acute cardiovascular events such as myocardial infarction and stroke. Current evidence indicates that somatic mutations in driver genes of clonal hematopoiesis significantly increase the risk of acute conditions such as acute myeloid leukemia and acute myocardial infarction. The high mortality and morbidity of cardiovascular and cancer diseases, and their strong association with clonal hematopoiesis, make it of indeterminate potential worthy of close attention.
Modern algorithms for statin therapy
Authors: Susekov V. A.
Published: November 2023

HMG-CoA reductase inhibitors (statins) are a key class of drugs for the treatment and prevention of atherosclerosis and its complications. This class of drugs has become firmly established in Russian and international guidelines with a high level of evidence. However, the use of these drugs in practice is not yet optimal. A significant proportion of patients at very high cardiovascular risk, taking initial doses of statins, do not achieve target levels of low-density lipoprotein cholesterol. The article is devoted to the analysis of international and Russian guidelines for statin monotherapy optimization, including their prescription in primary prevention using cardiovascular risk reclassification, coronary calcium score, carotid Doppler ultrasound and lipoprotein(a) levels.
Resting 12-lead electrocardiography for adults and children. 2023 Guidelines
Authors: Drozdov D. V. , Makarov L. M. , Barkan V. S. , Gazashvili T. M. , Efimova V. P. , Zhuk M. Yu. , Irtyuga O. B. , Kalinin L. A. , Kovalev I. A. , Komolyatova V. N. , Parmon E. V. , Rogoza A. N. , Struchkov P. V. , Tatarinova A. A. , Teregulov Yu. E. , Treshkur T. V. , Shutov D. V.
Published: November 2023

Russian Society of Cardiology (RSC)

Developed with the special contribution of the Russian Functional Diagnostics Association, Russian Holter Monitoring and Non-invasive Electrophysiology Society, Russian Pediatric Cardiology Association.
AI DBMS in modern-day applications
Authors: Shaw Barsha Rani , Halder Biprojit , Sen Soham , Basak Sumi , Bhattacharya Sumanta
Published: November 2023

The future of computing is anticipated to be shaped by the fusion of DBMS (Database Management Systems) and AI (Artificial Intelligence). This union is of utmost importance to advance DBMS technology and enable next-generation computing Although DBMS and AI systems are well-established
technology, research, and development into the combination of AI and databases is still in its early phases. The availability of vast volumes of shared data for knowledge processing, effective data, knowledge management, and intelligent data processing is the driving force behind this convergence.
The Intelligent Database Interface (IDI) architecture was developed to protect the significant investments made in current databases. Numerous well-liked techniques and developments for fusing AI with databases have been examined in-depth through extensive study and published articles.
Medical Reports Repository and Disease Analyser
Authors: Sinha Ranjita , Haldar Sandip , Chakraborty Joy , Ruidas Sathi
Published: November 2023

The healthcare industry is generating vast amounts of medical data daily, necessitating the development of a medical report repository and disease analyzer system. This system would enhance medical data management, leading to improved patient care. By centralizing patient medical data
securely, a medical report repository would enable healthcare providers to store and access information efficiently. Furthermore, a disease analyzer system, leveraging advanced techniques like machine learning and artificial intelligence, could assist healthcare professionals in identifying
patterns and trends in patient data. This early detection and prevention of diseases would significantly enhance patient outcomes. Through this blog, we will explore the advantages of a medical report repository and disease analyzer system, highlighting its potential to revolutionize healthcare
delivery.
Contactless Attendance System Using Raspberry Pi4
Authors: Roy Madhurima , Das Rajdeepa , Pal Rajatsubhra , Roy Kaushik , Chattopadhyay Joyati
Published: November 2023

Traditional attendance-taking techniques have sev- eral flaws. To address these challenges, most institutions have adopted a contemporary approach and embraced technology for greater accuracy, such as RFID and biometric systems. However, these systems have limitations of their own.
For example, RFID identification may be lost or misused, resulting in false identifica- tion, and biometrics can be time-consuming, which is a concern since attendance is typically collected during peak hours. Due to these difficulties, both of these strategies are inefficient. Our project
aims to create a contactless attendance system that uses deep learning-based facial recognition. This system will allow various businesses to save time and costs while improving security. Our project is an all-in-one package that includes both hardware and software and can be used without
the need for additional devices. This makes our proposed system both independent and user-friendly. The proposed hardware system consists of a Raspberry Pi 4, a camera for facial identification, a keyboard for ease of access, and a touch-enabled screen. We use OpenCV's face detection and the
deep learning-based dlib package, which allows our solution to be efficient on a low-power computing device like the Raspberry Pi, making it deployable anywhere.
"Guide-To-Go": A Cutting-Edge Approach to Building a Real-Time Travel Guide Application
Authors: Das Dibakar , Halder Monalisa , Mukhopadhyay Riddhiman , Atta Shubhadip , Dutta Jeet , Raul Chandan Kumar , Das Sayanti , Dutta Soumadeep
Published: November 2023

Tourism is one of the top three sectors disrupted by technology. Travel apps and websites are gaining attraction as a convenient and reliable source of information and guidance. The aim of the present work is to propose and develop website and an approach to an android application.
The paper illustrates the methodology, features, development method, and uses of our website named "Guide-To-Go".
Solar Energy & Smart City: The Status in India
Authors: Mondal Arghya , Bhattacharyya Sucharita
Published: November 2023

Solar energy is imperishable, easily available and clean source of energy. Depending upon solar irradiance, solar PV system produces variable output with requisite infrastructure. As modern civilization following industrial revolution shows an upward trend in consumption of electrical
energy, power shortage is inevitable. So all developed and many developing nation like India have started working with green energy projects for production of not only energy-efficient appliances but with drastic reduction in greenhouse gas emission as well. The net result is revival of the
environment but maintaining the pace of the economic growth and technological development of the country with smart cities. Implementation of Solar Energy projects with photovoltaic (PV) system is one such significant step considered globally along with India. In this work, different aspects
of solar energy are highlighted considering India's present status.
Human Centric Computing Applications for Laptop Price Prediction
Authors: Zahedi Mehboob , Jamal Danish , Das Abhishek
Published: November 2023

With the rapid enhancement of modern technology, we are more engaged with online shopping due to its high comfort, ease to use, safety etc. So we find a problem for laptop product evaluation in the online as well as offline market. The demand for laptops were rapidly increased after
the lockdown in India. In the June quarter of 2021, 4.1 million units were shipped and which is the highest shipment in five years. In laptops, the price is acquired from its RAM, ROM, CPU, GPU, Touch screen, model, trends etc. Sometimes it is very much difficult for the customer as well as
the retailer to fix a price with the certain characteristics of laptops so that both can evaluate the price and be satisfied with it. So we are going to develop a model for predicting the laptop price as per its properties. Because of any casual customer, this model will help in selecting
and deciding on a laptop whether to buy or not, and also will reduce the time and effort that anyone will have to spend manually researching the market price. This paper will focus on Human-centric computing applications for laptop price prediction because it can be analyzed by those well-
structured data that itself enhanced machine learning techniques, easily representable as a set of qualified parameters etc. So, we will develop an attribute-based prediction model for laptops using Regression machine learning algorithm.
Harnessing the Power of Convolutional Neural Network for Exoplanet Discovery
Authors: Gaurav  , Gupta Sumit
Published: November 2023

The discovery of planets apart from Earth that can sustain lives has always been fascinating as well as challenging. Discussion around such planets, popularly termed as "Exoplanets" have been doing the rounds for quite some time now. These exoplanets are often considered to be "Earth-like"
or "habitable" because they may have conditions that could potentially support life. This work focuses on how Deep Learning techniques can be useful in identifying potential exoplanets. To do so, astronomical data gathered by space telescopes such as Kepler and BRITE have been utilized.
The method employed to detect exoplanets is Transit Photometry along with Convolutional Neural Network. The study highlights the limitations of small training datasets and suggests the use of data augmentation techniques to increase the size of the training dataset, and the transfer learning
approach to improve the performance of the classification models. The research offers valuable insights into the nature and diversity of exoplanets and may open avenues for future discoveries. With a performance accuracy of 96.67%, the proposed approach showcases merit and hence can prove
to be a harbinger in exploring planetary habitability in the colossal space.
INSIGHT INTO METAL FOAM DOUBLE TUBE HEAT EXCHANGER: SIGNIFICANCE OF PORE DENSITY, PRESSURE DROP CHARACTERISTICS, AND PERFORMANCE ANALYSIS
Authors: Dhavale Aniket A. , Lele Mandar M.
Published: November 2023

This study investigates the integration of metal foam heat exchangers into solar flat plate collectors to enhance
their thermal performance, addressing a critical need for efficient solar energy utilization. The primary aim is to
comprehensively analyze the thermal and fluid flow behavior within this integrated system using numerical simulations
conducted with ANSYS Fluent v2021, with water as the working fluid to emulate real-world conditions. Three types
of metal foam materials, nickel, copper, and aluminum, with varying porosities (0.80 to 0.90) and pore densities (10
to 30) are considered, and the simulation results are rigorously validated against experimental data. In experimental trials, a nickel metal foam with a porosity of 0.90 and a pore density of 10 pores per inch (PPI) is inserted into the double tube heat exchanger's annular space, and measurements of temperature and pressure drop are collected both with and without the metal foam. The research employs Reynolds-averaged Navier-Stokes (RANS) equations coupled
with the k-epsilon model to simulate fluid flow and heat transfer phenomena, treating the metal foam heat exchanger as a porous medium due to its complex geometry. The study's major conclusion is the identification of an optimal metal
foam configuration that significantly enhances thermal performance in solar thermal applications. This conclusion
is grounded in a thorough evaluation of performance criteria and parameters. Additionally, the research provides
valuable insights for engineering design and optimization, ultimately advancing the development of more efficient and
sustainable solar thermal systems, which is of paramount significance in the pursuit of cleaner and more sustainable
energy sources.
Shear behaviour of sand–rubber mixtures: interpretation from energy transformation and force chain evolution
Authors: Guo Ning , Shi Yihao , Hu Zheng , Yang Zhongxuan
Published: November 2023

This study investigates the effect of rubber particles on biaxial shear responses of sand–rubber mixtures (SRMs) using a multibody mesh-free method, which enables the flexible and robust modelling of visco-elastic deformation of rubber particles. From the energy evolutions in SRMs with different rubber contents (RCs), including the incremental elastic strain energy, friction slipping dissipation and damping dissipation, it is found that the slipping dissipation is much more severe than damping dissipation for specimens with lower RC, but less significant for specimens with greater RC during shearing. In addition, the fraction of incremental strain energy increases with RC. Further investigations on the evolutions of force chain networks of SRMs indicate that the incorporation of rubber particles facilitates the stability of strong force chains by mitigating particle rotations in the strong force chains and relative sliding in the weak contacts. It is observed that the energy transformation in sheared SRMs has a strong correlation with their microstructural evolution.
Private Equity and Debt Contract Enforcement: Evidence from Covenant Violations
Authors: Haque Sharjil , Kleymenova Anya
Published: November 2023

Using the Shared National Credit supervisory data, we find Private Equity (PE) sponsored firms violate loan covenants more often than comparable non-PE firms. However, upon covenant violation, PE-sponsored borrowers experience relatively smaller reductions in credit commitments, suggesting lenders are more lenient with these borrowers. This limited-punishment effect exists in both covenant-heavy and covenant-lite loans but is stronger for banks with relatively higher capital. Limited punishment is driven by repeated deals and sponsor reputation, as well as the higher bargaining power of sponsors in loan renegotiation. Our results indicate sponsors generate financial flexibility by dampening debt contract enforcement for distressed borrowers.
Arte, discapacidad y posconflicto en Colombia
Authors: Bocanegra Cifuentes Melvy
Published: November 2023

Objetivo. Reflexionar sobre las relaciones entre el arte, la discapacidad y posconflicto colombiano, ateniendo a las intervenciones gubernamentales, de académicos de diversas disciplinas y a las memorias de las víctimas. Metodología. Para ello se realiza un análisis crítico de la literatura y se profundiza en el arte como camino para la construcción de la paz al apoyar los procesos de rehabilitación individual y colectiva y abrir espacios de creación, expresión y construcción de nuevos imaginarios. Resultados y Conclusiones. El trabajo logra establecer como la intervención artística en los procesos de transformación social aportan experiencias reflexivas, transformadoras y de proyección para los individuos y las comunidades.
Reconstrucción de la memoria histórica de la masacre de El piñal, Simití, Sur de Bolívar
Authors: Chávez Marín Eliana , Carballo Angarita Carmen Lisney , Quijano Mejía Claudia Milena
Published: November 2023

Objetivo. Divulgar los resultados del proceso de reconstrucción de la memoria histórica de la masacre ocurrida en la vereda El Piñal, Simití, sur de Bolívar, el 7 de agosto de 1999 realizada por los paramilitares. Metodología. Es una investigación de carácter cualitativo basada en la metodología propuesta por el Centro Nacional de Memoria Histórica, que privilegió el uso de talleres de la memoria y entrevistas a profundidad. Resultados. Se destacan los hechos previos a la realización de la masacre, referidos al secuestro del avión Fokker de Avianca por parte del ELN en la misma vereda, y los relatos de las víctimas sobre lo ocurrido antes, durante y después de la masacre, así como los daños y afectaciones producidos por este hecho y las formas de resistencia que la comunidad ha emprendido frente a la guerra. Conclusiones. El proceso de reconstrucción de la memoria contribuyó en la reparación de los daños morales causados a la comunidad, en tanto permitió dignificar la memoria de las víctimas.
Calidad en la educación superior: pandemia, virtualidad y relaciones interpersonales
Authors: Gallego Henao Adriana María , Gaviria Pérez Juan Luis , Arroyave Taborda Leisy Magdali , Yepes Álvarez Leidy Johana , Lopera Ospina Kelly Julieth , Hernández Osorio Yuseidy
Published: November 2023

El COVID-19 trajo nuevas dinámicas a las aulas de clase y con ello se modificaron las relaciones no solo educativas sino también interpersonales. Objetivo. Analizar las percepciones y experiencias de los estudiantes frente a la educación virtual en tiempos de la pandemia. Metodología. Cualitativa bajo el enfoque hermenéutico y se privilegió el estudio de caso como estrategia de investigación. Los participantes fueron 10 estudiantes de un programa de Educación Superior, a quienes se les aplicó la entrevista a profundidad por considerarla como técnica que permitía recuperar las percepciones frente al proceso educativo. Resultados. Tanto profesores como estudiantes exploran otras metodologías que les permitan aportar a los procesos de calidad educativa, sin desconocer las brechas sociales y económicas que vive hoy la educación. Conclusión. La virtualidad exige preparación y adaptación tanto de estudiantes y docentes para afrontar las nuevas realidades.
Early management of columellar skin necrosis post-revision septorhinoplasty
Authors: Ayman Y Jaber , Osama A Jbarah , Leen R Shahin
Published: November 2023

Background: Columellar skin necrosis is a rare complication of Septorhinoplasty procedures. However, it is more frequent in patients who undergo multiple revision procedures and have poor skin quality. Therefore, some patients require wound care immediately post-operation. Dressing of the columellar region is difficult due to the location and anatomical configuration. Case presentation: In this paper, we present a case of partial necrosis of the columellar skin following an open Septorhinoplasty procedure which was noted on the first post-operative day. Improving circulation to the affected area was the key target of the treatment approach. Conclusion: A topical hemoglobin-based oxygenating spray (Granulox, SastoMed GmbH, Georgsmarienhütte, Germany) was applied immediately on the columellar skin wound as it is a simple and easy dressing material and can lead to healing without obvious scarring. Key points Question: Would an early, minimally invasive intervention with a hemoglobin-based oxygenating spray in a patient who was diagnosed with partial columellar skin necrosis 24 hours post revision Septorhinoplasty - without the need for surgical management provide a satisfactory outcome? Finding and meaning: The treatment yielded a good aesthetic outcome in a short duration with no significant side effects and demonstrated the ease of treating a difficult complication without the need for more surgeries.
Big Data: Problems of Defining the Civil Law Regime
Authors: Ayusheeva I. Z.
Published: November 2023

Big data has significant potential value at the present stage, but its civil law regime remains uncertain. Today, big data technologies are inextricably linked with artificial intelligence technologies. In addition, it is impossible to determine the specifics of the legal regulation of the studied relations without solving such an aspect of the problem as the protection of personal non-property rights, since it is information about a person, their preferences, their personal data that acquires independent significance. Difficulties in identifying the features of big data as an object of civil rights are due to the fact that they include not only various types of information, but also technological solutions aimed at its collection, storage, processing and analysis. Based on the conducted research of regulatory sources, judicial practice and doctrine, it can be concluded that the exercise and protection of rights to big data is possible within the framework of relations developing over the results of intellectual activity, in connection with which the use of information included in big data and its processing can be carried out on the basis of license agreements with the copyright holder. If the information obtained as a result of the use of big data technologies is transmitted on the basis of the analysis of the information contained in them, then we can talk about the conclusion of a contract for the provision of services for the provision of information. When determining the civil law regime of big data, it is necessary to maintain a balance of public and private interests. When exercising the rights to big data, the rightholder must respect the personal non[1]property rights of persons whose information eventually forms a large amount of data, including ensuring the confidentiality of personal data, and in case of their dissemination, obtain the consent of the user in accordance with the procedure established by law.
Renin-angiotensin system gene polymorphism and aging
Authors: Bebyakova Natalia A. , Levitsky Sergey N. , Shabalina Irina A. , Komandresova Tatyana M. , Kudryavtsev Alexander V.
Published: November 2023

A personalized healthy aging program, aimed at preservation of functional capacities in old ages, should consider genetic (hereditary) factors that determine the structure and functions of body organs and systems, and their age-related changes. Individual genetic characteristics of a person can influence the aging process. For this reason, recent research focuses on identifying genetic mechanisms of aging and longevity associated with multifactorial diseases. Renin-angiotensin system (RAS) contributes to the development of pathological conditions leading to cardiovascular diseases, cognitive changes, disorders of auditory and visual analyzers, and may determine the preservation of functional capacities in older adults. We present a literature review of the role of the RAS gene polymorphisms in the aging processes. The results of the synthesis of Russian and international literature indicated the contribution of polymorphic variants of the angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II receptor type 1 (AGTR1) genes to the development of pathological conditions and the associated decreases in functional capacities of an elderly person. Testing for these polymorphisms can be of a practical importance for personified health assessment and development of timely preventive interventions aimed at improving life expectancy and quality of life among older adults.
LAD2 Mast Cell Activation Test Associates With the Reaction Severity and Diagnoses BAT Nonresponders in Hymenoptera Venom Allergy
Authors: Koren A , Dejanovic L , Kopac P , Erzen R , Bajrovic N , Zidarn M , Korosec P
Published: November 2023

Background: The usefulness of the mast cell activation test (MAT) in diagnosing patients with uninterpretable basophil activation test (BAT) results caused by nonresponding basophils has not been addressed. Our study evaluated whether the results of the MAT were associated with the severity of the allergic reaction.
Methods: We recruited 39 patients with Hymenoptera venom allergy (HVA), 22 nonsensitized controls, and 37 BAT nonresponding HVA patients. Specific IgE levels for honeybee venom (HBV) and yellow jacket venom (YJV) and total IgE were quantified using the IMMULITE® system. We performed a BAT and a MAT, which was based on the response of LAD2 cells to HBV and YJV.
Results: We first optimized the susceptibility of LAD2 cells to IgE-mediated degranulation in HVA and showed that prestimulation with IL-33 and IL-6 significantly increased the responsiveness of LAD2 cells to allergen stimulation (P<.01). The LAD2 MAT results correlated with the BAT results, and patients with severe sting reactions (Mueller grades III and IV) had a median 2-fold higher LAD2 MAT score than patients with nonsevere sting reactions (large local reaction or Mueller grades I and II) (P<.05). Furthermore, LAD2 MAT provided conclusive results in 20 of the 37 HVA patients (54.1%) with nonresponding basophils in the BAT.
Conclusions: The LAD2 MAT is a new diagnostic tool for HVA patients with nonresponding basophils. LAD2 MAT can identify patients at risk of severe sting reactions and can thus help guide recommendations for venom immunotherapy and improve the management of patients with HVA.
Prevalence of nocturnal enuresis among children aged 05 to 10 years
Authors: Khadke Dipak N. , Dasila Prabha , Kadam Nitin N. , Siddiqui M. Saeed
Published: November 2023

Background: Enuresis is common and considered to be normal among children younger than 3 years of age. Nocturnal enuresis is involuntary passage of urine during sleep among children five years of age or older. It is not a serious health problem, and children usually develop control over the bladder as they grow older but it can be upsetting for children as well as parents. India estimates 7 to 15 % prevalence rate among children and the numbers drop to 3 to 5% by the age of ten years. Objectives were to identify the children with Nocturnal Enuresis and assess their clinical profile.
Methods: A descriptive survey was conducted among the children age 05 to 10 years. Data were collected from two villages of Aurangabad district and the information was gathered from parents of 413 with the use of structured questionnaire. The first section included the socio- demographic characteristics of the children and their parents. The second section included variables related to the clinical profile and history of nocturnal enuresis in the family.
Results: The prevalence of nocturnal enuresis was 10.91% in which 06.94% were males and 03.97% females. With regard to severity 55% children were found to be in moderate category while 09% belonged to severe category of nocturnal enuresis. 
Conclusions: The prevalence rate was higher in selected villages. Most of the parents consider nocturnal enuresis as social stigma. Counseling and education of parents would help in improving general health of children in rural area.
Approach to diagnosis and treatment to urologic emergencies
Authors: Alzahrani Fahad Ahmed , Alhelali Hatim Osama , Alismail Khalid Itran , Alraddadi Khaled Soud , Alghamdi Mohammed Saeed , Alzhrani Khalid Hassan , Alahmadi Muhammad Abdulrahman , Alzahrani Bader Abdullah , Alshehri Saleh Ali , Basyouni Nourhan Sulaiman , Almarzooq Jawad Najeeb
Published: November 2023

Acute urinary retention, which is an emergency presents a significant challenge, for healthcare providers especially among elderly men. This condition often leads to dysfunction and genital pain causing distress and anxiety for those affected. The likelihood of experiencing acute urinary retention increases with age, with men in their 70s facing a 10% risk that escalates to, over 30% in their 80s. Dealing with both dysfunction and acute pain adds complexity to the clinical management of these cases. This summary highlights the role played by emergency physicians in the management of this troubling urologic emergency. The initial approach involves conducting an evaluation that includes assessing medical history performing physical examinations and conducting relevant diagnostic tests. Promptly identifying the causes, which can range from prostatic hyperplasia and urethral strictures to infections or neurogenic conditions is crucial. Pain relief is an immediate concern, prompting the administration of analgesics to alleviate patient discomfort. Concurrently, urinary catheterization, skillfully performed by the emergency physician, effectively resolves the urinary obstruction, providing substantial relief. Referral to urologists ensures a comprehensive etiological assessment and the formulation of an individualized management plan. In summary, effectively managing retention, with associated erectile dysfunction and genital pain, requires a collaborative effort between emergency physicians and urological specialists. By identifying the cause, providing skilled pain management and expertly performing urinary catheterization emergency physicians play a crucial role in relieving patient discomfort.
Vestibular migraine and its management in Indian clinical setting: a narrative review
Authors: M. Ilambarathi , Bijlani Avinash , Roy Dhrubo
Published: November 2023

Vestibular migraine (VM) is a disorder connecting two clinical conditions, migraine and vertigo. A high prevalence of VM (~30%) is reported among Indians suffering from dizziness. Yet, there is no gold standard for diagnosis and treatment. Trials specifically for patients with VM are scarce. This review provides an overview on VM and its management in the Indian clinical setting. An evidence-based discussion and review of literature on VM was performed by expert panelists, and opinions were gathered. Experts opined that in vertigo clinics, around 50% of patients are diagnosed with VM, with a higher predominance in females aged 30-50 years, while in children, the age of manifestation is 12-14 years. The most common presenting symptoms of VM among adults are spontaneous vertigo, followed by positional vertigo with headache, nausea, vomiting, photophobia and phonophobia, while intolerance to loud sounds and sudden falls are common symptoms in children with VM. Common comorbidities associated with VM are benign paroxysmal positional vertigo (BPPV) and Meniere’s disease (MD). Experts opined that there are currently no approved standardized treatment protocols for VM. The steps in the management of VM include diet and lifestyle modification, along with medicines for symptomatic relief (abortive) and prophylaxis and vestibular rehabilitation. Globally, prochlorperazine, a vestibular suppressant, is widely used for the management of vertigo and its associated symptoms. According to experts, prochlorperazine 5 mg twice or thrice daily for 5-7 days can play a significant role as an abortive treatment in the management of various patient profiles of VM.
Chronic Allergen Exposure Contributes to Steroid Resistance via Increased Phosphorylation of Glucocorticoid Receptors S226 and p38 MAPK in a Mouse Model of Asthma
Authors: Zhou Yan , Wang Limin , Jin Weizhong , Qiu Chenhui , Jin Hualiang
Published: November 2023

Chronic allergen exposure can significantly induce p38 mitogen-activated protein kinase (MAPK) activation in asthma. p38 MAPK is involved in steroid resistance through phosphorylation of glucocorticoid receptors (GR) at S226. This study aims to investigate whether chronic allergen exposure can induce steroid resistance and whether it is associated with p38 MAPK activation in asthma.
A mouse model of asthma was prepared by sensitizing and challenging mice with chronic ovalbumin (OVA) exposure. Key features of allergic asthma, encompassing bronchial hyperresponsiveness, pathology of lung tissues, cytokine profiles of inflammation in bronchoalveolar lavage fluid (BALF), and serum immunoglobulin (Ig)E concentration were evaluated. Furthermore, suppressive effects of corticosteroid on the splenocytes under stimulation of lipopolysaccharides, glucocorticoid receptor (GR) DNA binding ability of splenocytes, expression of GRα and phosphorylation of GR s226 in splenocytes, and p38 MAPK phosphorylation in splenocytes and lung tissues were determined.
Chronic OVA exposure substantially induced airway hypersensitivity, leading to increased inflammatory infiltration in lung tissues. Additionally, it resulted in elevated levels of interleukin (IL)-4, IL-5, and IL-6 in BALF, as well as heightened levels of IgE in serum. Furthermore, OVA exposure substantially enhanced p38 MAPK phosphorylation in lung tissues. It also weakened the suppressive impacts of corticosteroids on splenocytes, impaired the GR DNA binding ability, and led to an enhanced phosphorylated state of GR S226 and p38 MAPK in splenocytes.
Taken together, chronic allergen exposure contributes to steroid resistance in asthma, which is linked to an increased phosphorylated state of GR S226 and p38 MAPK.
MicroRNA-29a-3p Accelerates Inflammatory Damage in Neonatal Pneumonia Via Targeting Krüppel-like Factor 4
Authors: Xu Xiao Juan , Liu Wei , Liland ShiNa
Published: November 2023

Neonatal pneumonia (NP) is a frequently occurring illness during the neonatal phase. The study investigated the molecular process and the role of microRNA (miR)-29a-3p in NP.
Peripheral blood was collected from NP patients and healthy newborns. Human lung fibroblasts cell line (WI-38) were treated with lipopolysaccharide (LPS)) to establish a cellular model for NP. Then, miR-29a-3p and Krüppel-like Factor 4 (KLF4) levels were detected by RT-qPCR or Western blot. The relationship between miR-29a-3p and KLF4 was confirmed by dual luciferase reporter gene assay. Cell survival was assessed using the CCK-8 assay, whereas the levels of interleukin-6, tumor necrosis factor-α, and IL-1β were quantified using ELISA. Additionally, apoptosis was evaluated through flow cytometry. Meanwhile, Bax and Bcl-2 were detected by RT-qPCR. Neonatal rats were administered LPS intraperitoneally (3 mg/kg) to induce NP, and pathological injury and inflammatory reaction were analyzed.
MiR-29a-3p was elevated but KLF4 was silenced in NP patient’s serum, LPS-treated WI-38 cell line, and LPS-treated newborn rats. Silence of miR-29a-3p or elevation of KLF4 constrained cell proliferation with inflammation of LPS-treated WI-38 cell line. MiR-29a-3p immediately targeted KLF4. Additionally, silence of miR-29a-3p alleviated LPS-stimulated lung injury and inflammation in neonatal rats. The protective action of silenced miR-29a-3p in LPS-treated WI-38 cell line and newborn rats was turned around by silencing KLF4.
This study demonstrates originally that miR-29a-3p boosts inflammatory damage in NP via targeting KLF4, offering a basis for clinically diagnosing and treating NP.
Immunomodulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis Mice, A Multiple Sclerosis Animal Model
Authors: Robat-Jazi Behrouz , Oraei Mona , Bitarafan Sama , Mesbah-Namin Seyed Alireza , Noori-Zadeh Ali , Mansouri Fatemeh , Parastouei Karim , Anissian Ali , Yekaninejad Mir Saeed , Saboor-Yaraghi Ali Akbar
Published: November 2023

Previous studies noted an imbalance in T helper (Th) 17 and regulatory T cells (Tregs) in experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis animal model. calcitriol, vitamin D's active form, was found to ameliorate EAE symptoms by favoring Tregss over Th17 cells, suggesting immunomodulatory effects. This study aimed to assess calcitriol's impact on EAE manifestations and cytokine profile in mice.
In this study, we recruited twenty-eight C57BL/6 mice and divided them into 4 groups: healthy controls, EAE, EAE with calcitriol treatment, and healthy mice with calcitriol treatment. CD4+ T cells were isolated from splenocytes using magnetic-activated cell sorting. Real-time polymerase chain reaction was employed to quantify the genes associated with Th9 cells (i.e., SPI1 encoding PU.1 and IL9 encoding interleukin [IL]-9). Moreover, the levels of IL-17 and transforming growth factor beta (TGF-β) were evaluated through enzyme-linked immunosorbent assay in the supernatant of CD4+ T cell culture stimulated by anti-CD3 and anti-CD28 antibodies for 72 hours.
In the supernatant of CD4+ T cell cultures, the levels of interleukin-17 (IL-17) were significantly increased, while the levels of transforming growth factor beta (TGF-β) were decreased in the EAE Group compared to the healthy control group. Calcitriol treatment reversed these changes and attenuated EAE symptoms, as confirmed in hematoxylin and eosin, and luxol fast blue stains. Notably, calcitriol increased IL9 gene expression in both EAE and healthy mice.
This study provides further evidence of the anti-inflammatory effects of calcitriol and its role in attenuating EAE.
Combined Treatment of Progressive Encephalitis in an X-linked Agammaglobulinemia Patient
Authors: Yamazaki-Nakashimada Marco Antonio , Herrera-Mora Patricia , Mahrx-Bracho Alfonso , López-Herrera Gabriela , Bustamante-Ogando Juan Carlos , Scheffler-Mendoza Selma Cecilia
Published: November 2023

Most patients with X-linked agammaglobulinemia are susceptible to infections, while some cases also suffer from inflammatory or autoimmune complications. We describe a patient with progressive encephalitis who improved after the use of immunomodulatory treatment with corticosteroids, fluoxetine, and nitazoxanide. In most of the cases the evolution of the progressive encephalitis is complicated and catastrophic. Based on our experience and the review of the literature, we propose the use of this combined treatment to control this devastating complication.
Influence of Spacing and Weed Management Practices on the Growth Characters, Nutrient Removal of Weeds and Nutrient Uptake of Direct Seeded Rice
Authors: Mullaivendhan V. , Avudaithai S. , Rathika S. , Baskar M. , Sundar M.
Published: November 2023

Background: The field experiment was conducted at the Anbil Dharmalingam Agricultural College and Research Institute, Tiruchirappalli, Tamil Nadu during rabi, 2022-2023 to study the influence of spacing and weed management practices on growth characters, nutrient removal by weeds and nutrient uptake of direct seeded rice (DSR). Methods: The field experiment was laid out in split plot design with three replications. The main plots were spacing of 20 × 15 cm, 20 × 20 cm and 25 × 25 cm. Sub plots were assigned with weed management practices viz., pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + bispyribac sodium 10% SC at 25 g a.i ha-1 on 20 DAS as PoE, Pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + Cono weeding on 20 DAS + hand weeding (HW) on 40 DAS, Pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + Cono weeding on 20 DAS and 40 DAS, Pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + Bispyribac sodium 10% SC at 25 g a.i ha-1 on 20 DAS as PoE + Cono weeding on 40 DAS, Pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + Bispyribac sodium 10% SC at 25 g a.i ha-1 on 20 DAS as PoE + Hand weeding on 40 DAS, Hand weeding at 20 and 40 DAS and unweeded control. Result: The results indicated that the highest growth attributes, higher nutrient uptake of nitrogen, phosphorous and potassium under DSR and were significantly improved by spacing 20 × 20 cm along with pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + Bispyribac sodium 10% SC at 25 g a.i ha-1 on 20 DAS as PoE + Cono weeding on 40 DAS. This was on par with pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + Bispyribac sodium 10% SC at 25 g a.i ha-1 on 20 DAS as PoE + Hand weeding on 40 DAS and hand weeding on 20 and 40 DAS. Similarly lower nutrient removal by weeds were registered under 20 × 15 cm spacing along with pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + Bispyribac sodium 10% SC at 25 g a.i ha-1 on 20 DAS as PoE + cono weeding on 40 DAS. The interaction of spacing 20 × 20 cm and pyrazosulfuron ethyl 10% WP at 20 g a.i ha-1 on 3 DAS as PE + Bispyribac sodium 10% SC at 25 g a.i ha-1 on 20 DAS as PoE + Cono weeding on 40 DAS significantly increased the growth attributes such as plant height, dry matter production and total numbers of tillers and significantly lowered the nutrient removal by weeds.
Notes on the identity and taxonomic status of steno endemic Senecio lawsonii Gamble and Senecio lessingianus Gamble and Senecio lessingianus C.B. Clarke (Asteraceae) from the Nilgiri Biosphere Reserve, India
Authors: M. Premkumar , Murugesan M. , Karthik B. , Manikandan R.
Published: November 2023

The present article deals with the taxonomic status and the identity of steno endemic Senecio lawsonii Gamble and Senecio lessingianus C.B. Clarke (Asteraceae). Senecio lessingianus is reinstated here as a separate species. An updated nomenclatural citation, a detailed description, SEM images of pollen grains, phenology and notes on actual range distribution, conservation status and colour photo plates of the species are provided here to facilitate easy identification.
A historical and iconographic analysis of Charles Landseer’s Brazilian paintings
Authors: Wilkes Robert
Published: November 2023

This article presents a detailed examination of the two surviving Brazilian-themed paintings of Charles Landseer, the British artist who travelled to Brazil in 1825–26 as part of a diplomatic mission. His drawings in the Highcliffe Album are well-known, but the paintings are less familiar, and there has been a lack of art historical analyses of them within the broader context of the artist’s career. Furthermore, they have not been considered together before. Primary sources are used to present a new account of the paintings’ production and exhibition histories, uncovering previously overlooked information about how Landseer created the works and where he showed them in England in 1827. The article also incorporates lesser-known or previously unrecorded artworks by Landseer which relate to his Brazilian travels, including a third painting (depicting Madeira, not Brazil) which he exhibited in London in 1828, but which was only recently rediscovered. The only two known letters relating to Landseer’s involvement with the mission are transcribed in full in an appendix.
Modos de exibir, ver e interpretar
Authors: Couto Maria de Fátima Morethy , Malta Marize , Oliveira Emerson Dionisio Gomes de
Published: November 2023

A presente edição da Revista MODOS: Revista de História da Arte conta com vinte e cinco textos inéditos.  Destacamos os artigos do dossiê "Um inventário de instantes: coleções, acervos e conexões com a história da arte", proposto pela editoria da revista, em comemoração aos dez anos de existência do Grupo MODOS; anos dedicados a pensar a arte, a história da arte e o objeto artístico em suas várias dimensões e (in)materialidades, a partir de abordagens multidisciplinares.
A Systematic Literature Review of Student Assessment Framework in Software Engineering Courses
Authors: Fauzan Reza , Siahaan Daniel , Solekhah Mirotus , Saputra Vriza Wahyu , Bagaskara Aditya Eka , Karimi Muhammad Ihsan
Published: November 2023

Background: Software engineering are courses comprising various project types, including simple assignments completed in supervised settings and more complex tasks undertaken independently by students, without the oversight of a constant teacher or lab assistant. The imperative need arises for a comprehensive assessment framework to validate the fulfillment of learning objectives and facilitate the measurement of student outcomes, particularly in computer science and software engineering. This leads to the delineation of an appropriate assessment structure and pattern.
Objective: This study aimed to acquire the expertise required for assessing student performance in computer science and software engineering courses.
Methods: A comprehensive literature review spanning from 2012 to October 2021 was conducted, resulting in the identification of 20 papers addressing the assessment framework in software engineering and computer science courses. Specific inclusion and exclusion criteria were meticulously applied in two rounds of assessment to identify the most pertinent studies for this investigation.
Results: The results showed multiple methods for assessing software engineering and computer science courses, including the Assessment Matrix, Automatic Assessment, CDIO, Cooperative Thinking, formative and summative assessment, Game, Generative Learning Robot, NIMSAD, SECAT, Self-assessment and Peer-assessment, SonarQube Tools, WRENCH, and SEP-CyLE.
Conclusion: The evaluation framework for software engineering and computer science courses required further refinement, ultimately leading to the selection of the most suitable technique, known as learning framework.
Keywords: Computer science course, Software engineering course, Student assessment, Systematic literature review
Microplastic Pollution in Green Shells in Aquatic Ecosystems: A Literature Review of Determinant Factors and Management
Authors: Nurika Globila , Abidah Hilda Nur , Wikurendra Edza Aria , Ningtyias Farida Wahyu
Published: November 2023

Introduction: Water territories produce a large number of biota worldwide. The imbalance in conserving aquatic ecosystems, along with the increasing disposal of waste into the environment, has resulted in the risk of contamination of the environment and the resulting biota. The dangers of waste disposal into water can destroy the ecosystem and affect the usability of water for the environment and human beings. Discussion: The PRISMA method was used in this literature review, which examined 35 articles: 23 articles from ScienceDirect, 10 articles from Proquest, and 2 articles from PubMed. Data were analyzed by synthesizing the research variables compared with theory and then presented in the form of tables and figures. The results of this study are presented with a complete narrative description of three sub-discussions, which consisted of the characteristics of microplastics in green mussels (color, shape, size, and abundance). The color was acquired in the dark, with the predominant form of fibers <1 mm in size, which determined the amount of microplastics in green mussels induced by both human and industrial activities, as well as countermeasures through filtration of industrial effluents, the utilization of organic plastics, and policy enforcement. Conclusion: Microplastics found in green mussels in Asian waters vary in their characteristics, with the main determinants of human and industrial activities as well as multi-sectoral countermeasures.
The Efficiency of Ascaris Spp. Eggs Inactivation in Sewage Sludge by Lime Dosage, Ammonia Concentration, and Temperature Variation
Authors: Shabrina Husna Muizzati , Barti Setiani Muntalif  , Mayrina Firdayati
Published: November 2023

Introduction: Ascaris spp. eggs threaten sludge reuse because they are usually more environmentally resistant than other microorganisms. Consequently, the WHO recommended an acceptable limit of <1 helminth egg per gram of total solid as a health-based target for treated feces and fecal sludge and aimed to ascertain the effectiveness and reduction rate of Ascaris spp. eggs in sludge at various lime doses, ammonia concentrations, and temperature values. Methods: Eggs were detected and enumerated using the flotation and sedimentation principle. The reduction process was performed in batches with quick lime doses of 30% and 50% w/w, ammonia concentrations of 1,000 and 5,000 mg/L, and temperatures of 30°C and 50°C. Results and Discussion: The number of eggs of Ascaris spp. fertile in the ponds was 1.38 ± 1.38 eggs/gram to 42.98 ± 13.09 eggs/gram, and the infertile amount was 0.46 ± 0.80 eggs/gram to 17.82 ± 6.55 eggs/gram. Using a temperature of 40°C, 50% CaO, and 5,000 ppm ammonia resulted in the highest percentage of reduction, 97.98 - 98.09% but 1.12 eggs/gram was remaining. Conclusion: Higher pH and ammonia levels primarily affect egg decrease in Ascaris spp. To reduce 99% of Ascaris spp. eggs until it reaches <1 egg/g, a dose of 50% CaO is required, with 5,000 ppm ammonia at a temperature of 40°C for 2.7 hours.