bluuebunny/crossref_metadata_2025 huggingface dataset:
PERBEDAAN EMOSIONAL ORANG TUA YANG MEMAHAMI IT DENGAN TIDAK MEMAHAMI IT DALAM MENDAMPINGI BELAJAR DARI RUMAH PADA PESERTA DIDIK KELAS VII DI SMP NEGERI 4 KOTA TEGAL
Authors: Santi Puji Astuti  , Hartiinah Sitti , KW Sukoco
Published: March 2022

Perubahan kebijakan kurikulum pendidikan tersebut mengalami perubahan cara yaitu pada awalnya kegiatan belajar dilakukan secara tatap muka melainkan belajar dari rumah di dampingi orang tua. Tujuan penelitian ini adalah untuk mengetahui kondisi tingkat emosional orang tua yang kurang memahami IT dan memahami IT. Populasi yang dilakukan dalam penelitian ini sebanyak 70 Peserta didik, Karena seluruh populasi memiliki jumlah kurang dari 100 sehingga semua populasi dalam penelitian ini dijadikan sampel. Penelitian ini peneliti menggunakan pendekatan kuantitatif karena data yang penulis kumpulkan dianalisis menggunukan aplikasi SPSS IBM 25 dengan menggunakan uji  pra syarat homogenitas dan normalitas.

Analisis pengujian yang digunakian adalah uji t, uji  t yaitu yaitu untuk menguji bagaimana pengaruh masing-masing variabel bebasnya secara sendiri-sendiri terhadap variabel terikatnya. Berdasarkan perhitungan analisis uji t Hasil output di atas menunjukkan nilai uji t nilai signifikansi 2 arah (t-tailed) 0.000 <  0.05 maka hipotesis nol (nihil) (Ho) dapat dinyatakan bahwa hasil dari uji t tersebut diartikan “Terdapat Perbedaan Emosional Orang Tua Yang Memahami IT Saat Belajar Dari Rumah Pada Peserta Didik Kelas VII Di SMP Negeri 04 Kota Tegal Tahun Pelajaran 2021/2022. Saran yang diberikan dari hasil penelitian yang telah dilakukan kepada pembaca guru BK harus memiliki peran aktif membina peserta didik dalam mendampingi perkembangan emosional anak. Guru BK dapat membimbing tentang tingkat emosional orang tua perlu diperhatikan agar peserta didik mampu mengikuti belajar dari rumah dengan baik.
Six cases of occult sacral meningocele
Authors: Rahimizadeh Abolfazl , Soufiani Housain , Amirzadeh Mahan , Williamson Walter L.
Published: March 2022

Background:

Intrasacral occult sacral meningoceles (OSM) are uncommon congenital lesions that rarely become symptomatic, even over a patient’s life time.

Methods:

We operated on six patients with symptomatic OSM diagnosed on MR studies (all six) and/or CT examinations (four cases).

Results:

All six patients had uneventful postoperative recoveries. Nevertheless, despite the resolution of low back pain and radiculopathy, preoperative bladder dysfunction improved postoperatively in only one patient.

Conclusion:

Few cases of patients undergoing surgery for symptomatic OSM are reported in the literature. Here, we recount our experience with six patients with symptomatic OSM who demonstrated significant postoperative neurological recoveries except for rare improvement in bladder function.
Midline suboccipital approach to a vertebral artery–posterior inferior cerebellar artery aneurysm from the rostral end of the patient using ORBEYE
Authors: Murakami Tomoaki , Toyota Shingo , Nakagawa Kanji , Hagioka Tatsuya , Hoshikuma Yuhei , Suematsu Takuya , Shimizu Takeshi , Kobayashi Maki , Taki Takuyu
Published: March 2022

Background:

The midline suboccipital approach with the patient in the prone position is safe and effective for clipping vertebral artery–posterior inferior cerebellar artery (VA–PICA) aneurysms. Using a conventional surgical microscope from the rostral end of the patient for this approach without an extreme head-down position requires the surgeon to overhang the visual axis of the microscope and perform surgical manipulations in an uncomfortable posture. We report performing the midline suboccipital approach from the rostral end with slight head-down position using ORBEYE, a new high-definition (4K) three-dimensional exoscope.

Case Description:

A 65-year-old woman was admitted for clipping of a right unruptured VA–PICA aneurysm (maximum diameter, 5mm) located medially and ventral to the hypoglossal canal. After induction of general anesthesia, the patient was placed in the prone position with the head titled slightly downward. A midline suboccipital approach was performed from the rostral end of the patient using ORBEYE. Clipping was safely accomplished in a comfortable posture. No operative complications occurred. Postoperative computed tomography angiography showed complete aneurysmal obstruction.

Conclusion:

Exoscopic surgery using ORBEYE is feasible for a midline suboccipital approach to VA–PICA aneurysms from the rostral end of the patient with the patient in the prone with slight head-down position.
Concurrent intracranial infarct and intraventricular hemorrhage with spontaneous nontraumatic extradural hemorrhage in follow-up: An enigma of COVID-19-associated intracranial vasculopathy
Authors: Sreenivasan Sanjeev , Arora Chinmay , Vaishya Sandeep , Patir Rana
Published: March 2022

Background:

Several neurological manifestations have been described in the literature, in patients affected with COVID-19 infection. Some common forms include ischemic stroke, cardioembolic stroke, intraparenchymal hemorrhage, and multicompartmental hemorrhage. Concurrent brain infarct and intraventricular hemorrhage (IVH) have not been described in the literature previously.

Case Description:

A 35-year hypertensive and COVID-19-positive patient developed sudden-onset spontaneous IVH with concurrent infarct in the left internal capsule. In spite of undergoing an initial CSF drainage procedure, he had persistent worsening sensorium and increasing midline shift on CT imaging, so he underwent a left-sided decompressive craniectomy. One month after discharge, he developed spontaneous extradural hemorrhage at the operative site. In view of impending cerebral herniation, emergency hematoma evacuation was done, which restored his neurological status.

Conclusion:

This is the first reported detailed case of concurrent intracranial infarct and IVH in a patient affected with COVID-19 infection. We also report a rare phenomenon of nontraumatic noncoagulopathic extradural hemorrhage on the decompressive craniectomy site, in this patient 1 month after surgery.
The Use of Fetal Bovine Collagen on Chronic Wounds Increases Limb Salvage: A Single-center Retrospective Analysis
Authors: James Crystal , Patel Munir , Ellis Scott , Dudkiewicz Michael , Benvenisty Alan , Lantis II John
Published: March 2022

Objective. As part of a quality assurance project at a large tertiary care surgical program in New York City, the effect of debridement, negative pressure wound therapy, and cellular- and tissue-based products (CTPs) on limb salvage was evaluated based on the following outcomes: freedom from amputation, wound closure, and freedom from readmission. Fetal bovine collagen was among the CTPs evaluated. Materials and Methods. The data used in this study were derived from a database of all patients who had undergone procedures involving placement of a dermal matrix at the center over a 2.5-year period (January 2016–June 2018). This retrospective analysis included 256 patients who underwent debridement and/or placement of a CTP as part of the treatment course for chronic wounds. Results. Of the 252 patients identified, 34 required either minor or major all-cause amputation from the initial wound intervention, whereas for 218 patients, there were no recorded amputations through the end of the study period after the initial wound intervention. When fetal bovine collagen was evaluated as an explanatory variable to the presence of future amputation, a statistically significant relationship between the variables was found. Conclusions. The results of the current data analysis indicate that a treatment algorithm that includes appropriate antibiotic therapy, tangential hydrosurgery, application of fetal bovine collagen, and a short course of negative pressure wound therapy may be a more favorable option to achieve limb salvage, freedom from readmission, and wound closure.
Hematoma of the Lower Extremity: Operative Interventions in the Wound Clinic Setting
Authors: Treadwell Terry
Published: March 2022

Hematoma in the soft tissue, a swelling in the tissue caused by bleeding, is not an uncommon occurrence following trauma or operative procedures. Hematomas of the extremities can be seen in as many as 33 per 10 000 individuals annually. Most hematomas are considered minor problems following the initial injury; however, accumulation of blood in the tissues can result in necrosis of the overlying skin due to increased tissue pressure. Even in the absence of increased tissue pressure, multiple cellular and biochemical changes that can result in tissue ischemia and necrosis have been identified. To avoid these significant complications, prompt recognition and operative evacuation of these hematomas should be performed. The author presents 2 cases of hematomas that were evacuated using local anesthesia in the wound clinic setting.
Chiral Recognition and Stereoselective Reduction of Horse Ferricytochrome c by Optically Active Iron(ll) Complexes
Authors: Bernauer Klaus , Jauslin Pascal
Published: March 2022

The reduction of ferricytochrome c with the chiral complexes [Fe(alamp)] (alamp = N,N'-[(pyridine-2,6-diyl)bis(methylene)]bis[(R)- or (S)-alanine]) and [Fe(promp)] (promp = N,N'-[(pyridine-2,6-diyl)bis(methylene)]bis[(R)- or (S)-proline] is moderately stereoselective. The temperature dependence of the stereoselectivity shows ΔΔH#Δ-Λ/ΔΔS#Δ-Λ compensation behaviour giving crossing Eyring plots at 28° and 36° for alamp and promp, respectively. The activation parameters of the two ligands show inverted signs indicating that electron transfer with the corresponding Fell complexes probably does not occur in an identical geometrical environment.
Solution aggregation of two carbamazepine co-crystal systems as indication of nucleation pathways
Authors: Shen Yichun , Edkins Katharina
Published: March 2022

An investigation into the solution phase aggregation of carbamazepine/saccharin and carbmazepine/nicotinamide shows weak and strong interaction, respectively, though both systems co-crytallise easily. The strong self-aggregation of saccharin molecules restricts the interaction between carbamazepine and saccharin. The strength of interaction can be connected to different nucleation pathways.
General mechanism and mitigation for strong adhesion of frozen oil sands on solid substrates
Authors: Yang Qimeng , Moradpour Nikoo , You Jae Bem , Wang Dehui , Tian Boran , Sun Shaofeng , Liu Qi , Deng Xu , Daniel Dan , Zhang Xuehua
Published: March 2022

Oil sands adhered on truck bed reduce transport capacity of the truck, require manual cleaning, and create hurdles for automated surface mining. Study on the adhesion properties of oil sands to solid substrates is important to minimize the fouling of substrates during mining operation. In this work, we study the influence of hydrophobicity and mechanical properties of the substrates on the adhesion strength of frozen oil sands. By using an adhesion force apparatus with temperature control, we measure the adhesion strength of both ice and frozen oil sands on six types of substrates with water contact angle from ∼20◦ to ∼130◦ and Young’s modulus from a few MPa to 300 GPa. A clear linear correlation between the adhesion strength of pure ice and that of frozen oil sands is observed. Furthermore, the adhesion strength increases with the load on the oil sands sample and reaches a plateau at ∼450 kPa. The maximum adhesion strength may be due to the limit of particle packing of oil sands. We also demonstrate that spray coating of anti-freezing liquids is effective for the mitigation of the adhesion of frozen oil sands. Substrates coated with various anti-freezing liquids showed undetectable oil sands adhesion strength at -20 ◦C with 0.06 MPa of load. The study on oil sands adhesion and potential fouling mitigation method may provide a potential solution to industries looking to reduce fouling of surfaces by frozen granular matter.
Synthesis and styrene copolymerization of novel dibromo and dichloro ring-disubstituted isobutyl phenylcyanoacrylates
Authors: Ibrahim Daniah H. , Lee Chris J. , Madock Daniel N. , Marciniak Marcin , Montero Miguel A. , Orozco Juan , Ortiz Viany , Robles Mica C. , Rocus Sara , Schjerven William , Kharas Gregory B.
Published: March 2022

Novel dibromo and dichloro ring-disubstituted isobutyl phenylcyanoacrylates, RPhCH=C(CN)CO2CH2CH(CH3)2 (where R is 2,5-dibromo, 3,5-dibromo, 2,3-dichloro, 2,4-dichloro, 2,5-dichloro, 2,6-dichloro, 3,4-dichloro, 3,5-dichloro) were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-disubstituted benzaldehydes and isobutyl cyanoacetate and characterized by CHN analysis, IR, 1H and 13C NMR. The acrylates were copolymerized with styrene in solution with radical initiation at 70C. The compositions of the copolymers were calculated from nitrogen analysis.
Case Study on Amoxicillin Induced Hypersensitivity Reactions
Authors: Sai Sunil P.  , Priyanka C.  , Navya N.  , Datrinath V.  , Venkata Madhav P.  , Prasanthi M.
Published: March 2022

When compared to other Beta-lactam congeners, amoxicillin is considered to be the mainstay of treatment in the treatment of community-acquired bacterial infections (CABI) in infants. It is frequently prescribed and considered to be the best drug of choice due to its superior absorptive nature, followed by the oral route when treating CABI in infants. Drug hypersensitivity reactions are immune-mediated responses to drugs that cause a hypersensitivity reaction. Depending on when symptoms first arise, the World Allergy Organization advises defining hypersensitivity reactions as either immediate (symptoms appear within one hour of drug exposure) or delayed-type (symptoms appear beyond one hour of drug exposure) reactions. In the present study, we represent a case with a hypersensitivity reaction to amoxicillin. On Day 2 of admission, the patient was started on Tablet. Amoxicillin, Immediately after 3 hours of Amoxicillin use, the patient's attender complained of reddish rashes and raised body temperature in the patient. In our patient, ADR was managed by immediate withdrawal of the suspect drug Amoxicillin. Therapy was continued by another alternative drug available, Tablet Ciprofloxacin, Syrup, disodium hydrogen phosphate, to increase the rate of excretion and thereby prevent drug overdose inpatient.
INTENSIFICATION OF ECONOMIC GROWTH THROUGH THE DEVELOPMENT OF SPECIAL ECONOMIC ZONES UNDERTHE CORONAVIRUS OUTBREAK
Authors: Расулинежад Эхсан , Ходабин Захра , Хагпараст Хади
Published: March 2022

Глобальная пандемия коронавируса нанесла ущерб мировой экономике в масштабах, невиданных, по крайней мере, со времен Великой депрессии. Коронавирус (COVID-19) разрушает источники средств к существованию населения, бизнес и промышленность, человеческие ценности, особенно это касается развивающихся стран. Иран и Россия - две развивающиеся страны, которые не защищены от этих негативных воздействий пандемии, и кризис может иметь серьезные последствия в краткосрочной, среднесрочной и долгосрочной перспективе развития этих двух стран. Цель статьи - предпринять попытку объяснить развитие ОЭЗ как полезное решение для стимулирования экономического роста Ирана и России в условиях негативных последствий пандемии. Результаты показали, что обе страны - Иран и Россия - пытались развивать ОЭЗ в последние десятилетия, однако это стремление оказалось безуспешным из-за проблемы западных санкций и пандемии. Элементы научной новизны заключаются в выводах авторов - внедрение нового инструмента финансирования, такого как зеленые облигации, осуществление поворота в сторону Азии (азиатизации) и стимулирование инвестиций в проекты ОЭЗ со стороны частного сектора должны осуществляться при поддержке со стороны правительств Ирана и России.

The global coronavirus pandemic has wreaked havoc on the global economy on a scale not seen at least since the Great Depression. Covid-19 has the potential to negatively impact social welfare, businesses and industries, especially in developing countries. Iran and Russia are two developing countries that are not immune from these negative impacts of the pandemic, and the crisis could have serious consequences in the short, medium and long term development of these two countries. In this article, we try to explain the development of the SEZ as a useful solution to stimulate economic growth in Iran and Russia in the face of the negative effects of the pandemic. The results showed that both countries - Iran and Russia have tried to develop SEZs in recent decades, however, due to the problem of Western sanctions and the pandemic. Elements of scientific novelty lie in the authors' conclusions - the introduction of a new financing tool, such as green bonds, the implementation of a turn towards Asia (Asiatization) and the promotion of investment in SEZ projects by the private sector should be carried out with the support of the governments of Iran and Russia.
ASSESSMENT OF THE INNOVATION POTENTIAL OF ECONOMIC ENTITIES UNDER CONDITIONS OF DIGITAL TRANSFORMATION
Authors: Кострова Алла Анатольевна , Дюдюкина Алена Михайловна
Published: March 2022

Цель статьи - обобщение и систематизация существующих методик оценки инновационного потенциала экономических субъектов, обоснование необходимости совершенствования способов его оценки в условиях цифровой трансформации основных бизнес-процессов. Научная новизна заключается в разработке методики оценки инновационного потенциала экономического субъекта с учетом выделения digital-емкой составляющей в структуре одного из важнейших индикаторов его конкурентоспособности.

The article substantiates the need to develop approaches to solving the problems of innovative development of economic entities on the basis of an integrated assessment and improvement of the methodology for managing the innovative potential of the organization. The proposed methodology makes it possible to assess the innovative potential in the conditions of digital transformation of the main business processes, taking into account their industry affiliation. The authors reveal the differences between the developed methodology and traditional methods of assessing the innovation potential, in particular, due to the allocation of a digital-intensive component in the structure of one of the most important indicators of the competitiveness of economic entities.
Aplikasi Group Technology Pada Perancangan Alat Bantu Pegang (Fixture) untuk Proses Pembuatan Komponen
Authors: Yusuf Edhy , P Gianti , Sujatmiko M , Wahyudin C , Hamid R J
Published: March 2022

Tahapan penting pada proses produksi komponen di suatu industri manufaktur adalah proses perancangan dan pembuatan fixture yang menjadi prasyarat untuk terlaksananya proses pembuatan komponen tersebut. Industri manufaktur sering menghadapi masalah dalam perancangan dan pembuatan fixture, karena untuk setiap pesanan komponen yang baru diterima harus dirancang dan dibuat fixturenya. Kegiatan perancangan fixture membutuhkan keahlian yang spesifik dan waktu yang panjang, yang berimplikasi pada lead time pembuatan komponen yang panjang.

Suatu komponen sering memiliki kesamaan bentuk geometris dengan komponen yang lain, sehingga fixture yang digunakan untuk proses pemesinan komponen-komponen tersebut pun sering memiliki kesamaan. Fixture yang dirancang sangat berkaitan dengan jenis dan bentuk geometri komponen yang dibuat (bentuk, ukuran), jenis material sertra proses pengerjaan dan jenis pemesinan yang diperlukan. Kesamaan bentuk geometris komponen (produk) dan sifat-sifat lain yang berimplikasi pada kesamaan bentuk fixture yang digunakan diduga dapat digunakan untuk menyederhanakan proses perancangan fixture, yaitu dengan mengelompokkan komponen (produk) yang dibuat dengan menggunakan pendekatan group technology.

Penggunaan pendekatan group technology akan memudahkan perancangan fixture yang dibutuhkan, karena tidak perlu semua tahapan perancangan dilakukan. Pesanan untuk komponen baru yang diterima suatu industri manufaktur dikelompokkan ke dalam kelompok yang sudah dibuat, dan pada setiap kelompok tersebut telah diuraikan bentuk geometri dasarnya, jenis materialnya dan berbagai sifat yang menunjukkan kesamaan. Untuk setiap sifat tersebut (bentuk dasar geometri, jenis material, dsb) ditentukan bentuk fixturenya yang tepat. Oleh karenanya, proses perancangan fixture untuk komponen yang baru diterima dilakukan dengan mengkombinasikan bentuk dasar fixture yang telah dibuat untuk kelompok yang bersangkutan.

Penelitian aplikasi group technology pada perancangan fixture telah dilakukan untuk komponen pesawat terbang N250 dan Boeing 737, dan memberikan waktu perancangan Jixture yang lebih pendek dibandingkan dengan perancangan tanpa menggunakan pendekatan group technology. Pendekatan ini diduga dapat juga digunakan untuk perancangan fixture pada industri manufaktur pembuat komponen umumnya, termasuk pada industri kecil pembuat komponen.
ALFABETIZAÇÃO E LETRAMENTO: ESTUDO SOBRE OS ASPECTOS PRAGMÁTICOS DA LEITURA
Authors: Barreto Jussara Marques
Published: March 2022

Na contemporaneidade, a leitura e a escrita ganham importância significativa na vida do indivíduo. Ambas proporcionam a inserção social através do acesso à informação, do desenvolvimento da criticidade, da criatividade e da ampliação de vocabulário. Esses aspectos contribuem para a ampliação da discussão sobre a importância da leitura na construção da identidade do indivíduo,além de elucidar a promoção do entendimento da realidade. Esta leitura tem como objetivo explicitar o conceito de alfabetização, ressaltando a formação do leitor e as funções da leitura, bem como as contribuições para as práticas pedagógicas que envolvem o desenvolvimento da leitura e da escrita.Palavras-chave: Alfabetização. Letramento. Leitura.
Laboratory experimental and numerical thermal response tests in thermal piles prototypes in tropical soil
Authors: Chaves Charles Pereira , Silva Juan Deyvson José Camilo , Cunha Renato Pinto , Cavalcante André Luis Brasil
Published: March 2022

This paper provides preliminary results on geothermal energy piles (GEPs) for the thermal climatization of structures founded on the typical tropical unsaturated soil of the central region of Brazil. The research employed a series of prototype simulations of a thermal pile embedded into a calibration chamber with compacted unsaturated soil. It closely simulates the behavior of a (prototype) section from real scale GEPs founded in the geotechnical media of the region, in terms of compactness, mineralogy, water content and thermal variables. One of the on-going thermal tests was numerically simulated with a Multiphysics commercial software to calibrate a model and expand the results to possible scenarios of distinct (laboratory) GEP performance. The analyses will base future simulations of typical foundation layouts for large-scale structures founded on tropical soils of the region to verify the thermal energy efficiency under average operational conditions. Besides the known limitations of this research, still at early stage, an initial assessment was achieved to design shallow geothermal systems for local conditions.
Hemosorption efficiency for suppressing the cytokine storm caused by coronavirus SARS-CoV-2
Authors: Yakubtsevich R. E. , Rakashevich Dz. N. , Neuhen I. N.
Published: March 2022

Coronavirus infection is a clinical syndrome caused by a mutational RNA virus (SARS-CoV-2). In severe cases, it is characterized by the development of a “cytokine storm”. The latter leads to the multiple organ dysfunction, ARDS and causes high mortality. To suppress the cytokine aggression in patients with severe COVID-19, the drug suppression is recommended; however, the use of hemosorption can be pathogenetically justified as an alternative method.

The aim of the study was to assess the effectiveness of hemosorption using the hemosorbent “Hemo-Proteazosorb” in the severe COVID-19 infection course in comparison to the drug suppression with tocilizumab.

We studied the clinical and laboratory parameters of 88 patients who were treated at the anesthesiology and intensive care department. All patients were divided into 2 groups: Hemo-Proteazosorb (n = 53) and Tocilizumab (n = 33).4

Against the background of hemosorption using the Hemo-Proteazosorb sorbent, statistically the level of procalcitonin, C-reactive protein, leukocytes, fibrinogen, D-dimers significantly decreases, the number of lymphocytes increases, as well as the respiratory index earlier grows in comparison with the group receiving tocilizumab therapy. The study found that the use of hemosorption through the domestic sorbent “Hemo-Proteazosorb” has a number of advantages over the drug suppression of the “cytokine storm” with tocilizumab due to the more pronounced effects of immunomodulation, improvement of the oxygen transport function of blood, its rheological properties and the possibility of effective use in persons with viral bacterial infection.
Expression of the Fasn and Sirt4 genes and the proteins they encode in the visceral adipose tissue of Wistar rats against the background of excess fat intake
Authors: Poluliakh O. Y. , Kalinovskaya E. I. , Basalai A. A. , Mihalevich A. S.
Published: March 2022

The changes in the expression of the lipogenic Fasn and Sirt4 genes and the Fasn and Sirt4 proteins they encode in the visceral adipose tissue of Wistar rats against the background of excess fat intake were studied.

In addition to the standard vivarium diet, the rats received the animal fats (45 % of daily caloric value) for 8 weeks. A relative gene expression was determined by real-time PCR, protein content in the visceral adipose tissue - by the ELISA method.

It was found that the excess animal fat intake leads to a decreased expression of lipogenic Fasn and Sirt4 genes and the proteins they encode in the visceral adipose tissue of Wistar rats, which indicates the formation of the adipose tissue dysfunction, which may result in the impared lipid and carbohydrate metabolism, the insulin resistance development.
Immunological efficiency of the pooled mesenchymal stem cells of the olfactory lining of the nasal cavity for systemic lupuserythematosus treatment
Authors: Rynda A. H. , Hancharou A. Y. , Chyzh K. A. , Antonevich N. G. , Rabcava T. Y. , Minich Y. S. , Mantsivoda V. E.
Published: March 2022

An important place in the pathogenesis of systemic lupus erythematosus (SLE) is given to the immune mechanisms, many aspects of which, despite intensive study, remain unclear. As a result of the activation of T and B cells, the production of antibodies (including autoantibodies) increases, hypergammaglobulinemia occurs, and immune complexes are formed. The use of mesenchymal stem cells (MSCs) as the basis of a biomedical cell product for SLE cell therapy is justified due to the fact that this type of stem cells has a wide immunomodulatory activity range. In recent years, more and more data have appeared that the pooled cultures of allogeneic MSCs have more pronounced and stable immunomodulatory properties in relation to immunocompetent cells, in comparison with allogeneic MSCs obtained from a single donor.

The aim of the study was to develop a biomedical cell product based on pooled cultures of MSCs to increase the effectiveness of the existing methods of treating SLE.

The object of the study was the venous blood of SLE patients with clinical and laboratory lupus nephritis signs included in the trials (n = 6). Blood sampling and analysis were carried out before cell therapy and 1-1.5 months after. Immunophenotyping of blood cells was performed using flow cytometry.

The immunological efficacy of SLE cell therapy, which was expressed in a decrease of the number of immunocompetent cells associated with the inflammation process in the peripheral blood (decrease in the content of cytotoxic lymphocytes, activated and terminally differentiated TEMRA T cells, decrease in the number of antibody-producing plasma cells) with the use of poolMSC was shown. Clinical efficacy consisted in stopping the progression and reducing the SLE activity (doubling the SELENA-SLEDAI index from 10.43 to 5.14), as well as in achieving the complete LN remission (n = 4) and restoring the normal kidney function.
Prognostic significance of blood clotting indicators for determination of the probability of developing the hemorrhagic syndrome in premature newborns with congenital pneumonia
Authors: Harachka A. N. , Sukalo A. V.
Published: March 2022

One of the main complications of congenital pneumonia in premature newborns, leading to high mortality, is the development of hemorrhagic syndrome. Objective - to determine the prognostic significance of blood clotting indicators and the probability of developing hemorrhagic syndrome in premature newborns with congenital pneumonia.

The assessment of hemostasis indicators in 221 premature newborns who were treated and cared for in the State Institution RSPC “Mother and Child” in the period from 2017 to 2019 was carried out. A comparative analysis of the parameters of the coagulogram of the first day of life was performed with the allocation of the percentile range and the translation of absolute values into binary variables is made. Based on the results of the ROC analysis, a mathematical model was developed with a universal coefficient equal to χ2 = 24.19, p = 0.004, with a sensitivity of 92.9 % and an area under the ROC-curve AUC = 0.69 ± 0.039 (0.62-0.76), p < 0.001, and a computer support program for doctors. The prognostic significance of blood clotting parameters was calculated: activated partial thromboplastin time - 0.366, coefficient R - 0.208, prothrombin time - 0.321, prothrombin index according to Quick - 0.330, international normalized ratio - 0.242, thrombin time - 0.319, fibrinogen -0.295, D-dimer - 0.448, platelets - 0.478, which makes it possible to allocate premature newborns with congenital pneumonia with a threshold value of ≥0.293 to the risk group for the development of hemorrhagic syndrome.
Wastewater reclamation design from sewerage system for gardening activity in Universitas Pertamina
Authors: Pavita Khansa  , Evi Siti Sofiyah  , I Wayan Koko Suryawan
Published: March 2022

Wastewater recycling is one of the criteria for continuous innovation at the campus level. Reclamation of water from the sewage system for gardening activities is one way to achieve this target at Universitas Pertamina. The aim of this study is to design and verify a water treatment unit from sewage to ready-to-use water for gardening activities. The units needed for the wastewater treatment system are a tank, Horizontal Roughing Filter (HRF), Rapid Sand Filtration (RSF), reservoir, and disinfection. The expected quality of effluent from processing is TDS 278 mg/L; TSS 1.3 mg/L; Turbidity 0.17 NTU; BOD5 0.63 mg/L; COD 6.12 mg/L; Total phosphate 0.95 mg/L; Nitrate 0.07 mg/L; detergent 0.7 mg/L; and total coliform MPN/100mL. The most important parameter in the sewerage water treatment process is the total coliform which must achieve an efficiency of 99%. This conventional method of water treatment is used because the availability of land is still sufficient, if it is not sufficient then further processing that is efficient, environmentally friendly, and has economic value is required.
Suitability of mangrove ecotourism in Payo Village, West Halmahera Regency
Authors: Riyadi Subur  , Abubakar Salim , Susanto Adi Norman
Published: March 2022

The uniqueness of the mangrove ecosystem is a potential that can be developed as an ecotourism destination. Ecotourism activities are one of the many alternatives to overcome environmental problems in the mangrove ecosystem. The research objective was to assess the suitability of mangroves as an ecosystem for the ecotourism area of ​​Payo Halmahera Barat Village. The research used a survey method, which is to directly measure the biophysical conditions of mangroves. The results showed that the suitability value of the mangrove ecosystem for ecotourism was 73.86%, with the "appropriate" or (S2) category.
Curcuma longa as a Natural Immunomodulator for Preventing infection from COVID 19 With an In Silico Approach
Authors: Mauliana Lely , Jamil Ahmad Shobrun , Siti Siti
Published: March 2022

SARS-CoV-2 is a Coronaviridae virus with a single-stranded RNA genome. This virus is highly contagious and spreads rapidly, with mutations occurring at a rapid pace. Various preventive actions have been implemented to prevent the spread of Covid-19 instances. The World Health Organization recommended that everyone clean their hands, masks, and other items in their environment on a frequent basis. As a result of these measures, the virus's transmission will be slowed. Furthermore, keeping one's immune system is critical for limiting the spread of Covid-19. As a result of a weakening immune system, our body's defenses will deteriorate, making us more susceptible to sickness and unable to fight diseases caused by viruses or bacteria. If the immune system is strong, it will recognize and kill viral and bacterial compounds when they are exposed. Immunomodulators, such as natural vitamins and herbs, can help maintain and boost immunity. Indonesia is primarily a farming country. In Indonesia, many different varieties of plants can be grown. Turmeric is an Indonesian medicinal plant that may be found all across the country. Turmeric's ability to act as an immunomodulator has also been proven. As a result, the goal of this study is to determine the usefulness of the active chemicals found in the Curcuma longa plant as a natural immunomodulator in order to avoid mutations of the COVID 19 variation by looking at the background of the current situation. The approach employed in this study is an in silico Molecular Docking test, with the goal of determining the active side of the drug and the value of Binding Affinity from the Docking data. Tissue Pharmacology is used to depict the protein network found in turmeric plants, as well as the substances and diseases that are linked to these proteins. According to the findings, the compound quercetin acts as a ligand for the PIK3CG protein and has a high binding affinity of -7.4. As a result, it can be identified as a substance that acts as a natural immunomodulator in turmeric plants.
Colorimetric Reverse Transcription-Loop-Mediated Isothermal Amplification (RT-LAMP) in rapid detection of SARS-CoV-2
Authors: Samyra Sthéfane Neves Pereira  , Rubens Pasa  , Fabiano Bezerra Menegídio  , Luanda Medeiros-Santana  , Liliane Evangelista Visôtto  , Everaldo Antonio Lopes  , Karine Frehner Kavalco
Published: March 2022

Diagnosis by RT-LAMP (Reverse Transcription–Loop-Mediated Isothermal Amplification) is relatively simple, fast and requires inexpensive equipment. The result is visualized with the naked eye, and therefore, has the potential to become popular among molecular tests for viral detection. This work aimed to test and validate different RT-LAMP protocols for diagnostics of SARS-CoV-2. To this end, we used 20 samples that had been tested at the Laboratory of Molecular Diagnostics for SARS-CoV-2 by RT-PCR, with results ranging from “detected to undetected”. The colorimetric RT-LAMP results were compatible with those obtained by RT-PCR in 95% of the cases. The results show good sensitivity and fidelity of the test. Its applicability detecting SARS-CoV-2 can be important for massive testing.
Research on the influence of China's transfer payment system on the equalization of basic public services
Authors: Xiaoqian Guo Wei Wang
Published: March 2022

Realizing the equalization of basic public services is of great significance for promoting social harmony and narrowing the regional development gap. Since 2006, China has officially proposed "equalization of basic public services" Since then, the gap of basic public service level between the eastern and western regions of China has narrowed year by year, but inequality still exists. Transfer payment system is the most important policy tool to realize the equalization of basic public services in China. This paper uses the variation coefficient method to analyze the internal reason for the narrowing of the gap, that is, the impact of China's transfer payment system on the equalization of basic public services. On this basis, in view of China's national conditions and foreign successful experiences, this paper puts forward some countermeasures and suggestions to improve the transfer payment system and promote the equalization of basic public services from the aspects of establishing a sound legal system, normalizing the direct fund management mechanism, and clarifying the division of routine powers and responsibilities.
Farmers-Herdsmen conflicts: Effect of Resilience Strategy on Arable crop Productivity in the Ogbomoso Agricultural Zone of Oyo State
Authors: Olagbemiro MF  , Ojediran JT  , Oladipupo OK  , Ezekiel AA
Published: March 2022

Over the years, contests over land for crop production and pasture for animals among crop farmers and herders have been a subject of concern. The study therefore examine the effect of resilience on arable crop productivity after farmers-herdsmen conflicts in the Ogbomoso Agricultural Zone of Oyo State. A multistage sampling technique was used to select 270 arable crop farmers, which is about 29.4% of the 919 registered arable crop farmers for the study, using a structured questionnaire to obtain primary data. Data collected was analysed using descriptive statistics like tables, percentages and inferential statistics such as ordinary least square regression to analyse the effect of resilience strategy to shocks of conflict anticipation cost and arable crop productivity. All analyses were tested at a 5% level of significance. The result of the OLS regression analysis model for the effect of resilience techniques on arable crop productivity indicated that years spent in school (p = 0.97), size of farm (p = 0.006), hired labour after conflict (p = 0.000), transformative index (p = 0.000), absorptive index (p = 0.008) and adaptive index (p = 0.008) were significantly related to arable crop productivity. The transformative, absorptive, and adaptive resilience strategies significantly influenced arable crop productivity after farmers-herdsmen conflicts in the study area. The study concluded that adhere to the rule and regulations of the community serve as a means of preventing conflicts between farmers and herders, Further increasing farm size requires more commitment from the farmer and thus becomes more attached to the farm materially, physically and emotionally. The study recommends that the resilience strategies employed by the respondents should be investigated and adopted by appropriate authorities in order to mitigate the regular conflicts between farmers and herders in Nigeria.
Authors: Anisah Siti
Published: March 2022

Anisah, Siti. 2020. Penerapan Guided Discovery Learning Mode Daring  untuk Mengembangkan Prestasi Belajar Siswa Pada materi matriks Di Kelas XI SMA NURUL JADID. artikel, Jurusan Pendidikan Profesi Guru, FMIPA, Universitas Muhammadiyah Gresik. Pembimbing: Dr. Irwani Zawawi, M.Kes. Penelitian ini mendeskripsikan rancangan dan pelaksanaan pembelajaran matematika dengan menggunakan Guided Discovery Learning untuk melihat prestasi belajar siswa kelas XI SMA NURUL JADID pada materi matriks. Hasil penelitian tindakan kelas ini menunjukkan bahwa presentase banyaknya siswa yang tuntas belajar pada siklus 1 adalah 30,8% sedangkan presentase banyaknya siswa yang tuntas belajar pada siklus 2 adalah 57,7% dan presentase banyaknya siswa yang tuntas belajar pada siklus 3 adalah 84,6% . Menurut ketuntasan pembelajaran yang ditetapkan SMA NURUL JADID, pelaksanaan pembelajaran dikatakan mendukung atau berhasil apabila sekurang-kurangnya 80% siswa mendapat nilai minimal 75 sehingga dalam hal ini dapat disimpulkan bahwa pembelajaran dengan  Guided Discovery Learning dalam penelitian ini berhasil. Hal ini dapat diperkuat dengan hasil observasi aktivitas siswa yang masuk dalam kategori “Sangat baik” pada siklus 1, siklus 2 dan siklus3.
Authors: Setyowati Kartika Budi
Published: March 2022

Penelitian ini bertujuan untuk mewujudkan pembelajaran matematika yang aktif pada siswa kelas XII TIB SMK YAPPI Wonosari menggunakan model pembelajaran Discovery Learning. Jenis penelitian ini adalah Penelitian Tindakan Kelas. Subjek dalam penelitian ini adalah siswa kelas XII TIB SMK YAPPI WONOSARI. Objek dalam penelitian ini adalah keseluruhan proses dan hasil kegiatan pembelajaran matematika dalam meningkatkan terwujudnya pembelajaran matematika yang aktif menggunakan model pembelajaran Discovery Learning. Instrumen dalam penelitian ini adalah observasi pembelajaran aktif. Penelitian ini dilaksanakan tiga siklus, siklus pertama terdiri dari satu pertemuan, siklus kedua terdiri dari satu pertemuan, dan siklus ketiga terdiri dari satu pertemuan. Teknik pengumpulan data dalam penelitian  ini adalah observasi. Pembelajaran dilaksanakan secara daring melalui Learning Management System (LMS) berbasis Moodle, zoom meeting serta WAG. Penelitian ini menunjukkan bahwa pembelajaran aktif telah tercapai. Hal ini ditunjukkan dengan adanya peningkatan persentase setiap indikator pembelajaran aktif dari siklus I ke siklus II dan siklus III melalui observasi. Hasil observasi menunjukkan peningkatan persentase pembelajaran matematika yang aktif dari siklus I ke siklus II dan siklus III yaitu: Siklus 1 34,4%, siklus 2 41,13%, dan siklus III 60,13%. Tindakan telah mencapai indikator keberhasilan pada siklus III.
Authors: Wiratama Novialita Angga
Published: March 2022

Penelitian ini bertujuan untuk memaparkan penerapan google meet dalam perkuliahan daring mahasiswa PGSD mata kuliah Konsep Dasar PKn SD saat pandemi covid 19. Subjek penelitian ini adalah mahasiswa PGSD angkatan 2020 kelas A dan B berjumlah 89 mahasiswa. Jenis penelitian yang digunakan merupakan penelitian deskriptif dan metode kualitiatif. Dimana penelitian ini mendeskripsikan penerapan google meet dalam perkuliahan. Metode kualitatif dalam penelitian ini bersifat artistik, karena proses penelitian lebih bersifat seni (kurang terpola) dan disebut juga sebagai metode interpreative karena data hasil penelitian lebih berkenaan dengan interprestasi terhadap data yang ditemukan di lapangan. Data hasil penelitian bahwa aplikasi google meet dalam pembelajaran daring mahasiswa PGSD menyatakan sangat mudah dalam mengakses yaitu 70 mahasiswa  sedangkan yang mengalami kesulitan hanya 2 mahasiswa. Pemahaman materi dalam perkuliahan daring menggunakan google meet ini 25 mahasiswa menyatakan sangat setuju materi dapat dipahami dengan baik.  Keefektifan penggunaan aplikasi google meet dalam pembelajaran daring ini 11 mahasiswa menyatakan sangat efektif sementara 32 mahasiswa menyatakan kurang setuju dalam keefektifan pembelajaran. Mahasiswa yang kurang paham terhadap materi dikarenakan terkadang signal putus karena cuaca mendung atapun hujan. Hal ini dosen memberikan solusi selalu mengirimkan diktat materi perkuliahan sebelum kegitan perkuliahan daring pada whatsaap group, sehingga semua mahasiswa dapat mengikuti perkuliahan tanpa tertinggal materi karena terkendala signal. Evaluasi terhadap penggunaan google meet dalam perkuliahan daring setelah melalui 6 kali pertemuan mahasiswa mengingingkan dapat belajar menggunakan metode luring.  Menurut mahasiswa lebih mudah memahami materi perkuliahan jika dilakukan secara tatap muka secara langsung tanpa melalui jaringan (daring).
Authors: Alfiansyah Iqnatia , Subayani Nataria Wahyuning , Nugroho Arya Setya
Published: March 2022

Tujuan dari kegiatan pengabdian masyarakat yang dilakukan ini adalah untuk meningkatkan produktivitas guru SD terutama alumni PGSD UMG dalam hal kegiatan menulis karya ilmiah. Sebagai guru muda, semangat untuk berinovasi seharusnya termotivasi dan terfasilitasi agar guru muda yang telah terjun lapangan, semakin meningkatkan produktivitas dan kreatifitasnya. Agar menjadi guru, bukan hanya sekedar menyampaikan materi ajar, namun juga misi penelitian dan inovator. Dalam mewadahi kreativitas dan menyalurkan hasil penelitian yang berupa karya ilmiah, maka kami dari tim dosen S1 PGSD melaksanakan pengabdian kepada para guru muda agar penelitian yang telah dilakukannya sebagai guru terpublish. Kegiatan pengabdian masyarakat ini berupa pelatihan penulisan karya ilmiah berupa artikel ilmiah hingga penerbitan (publikasi) artikel ilmiah melalui jurnal online. Rangkaian kegiatan meliputi, 1)Persiapan,dengan mempersiapkan bahan KTI yang baik, 2) penulisan, dengan memulai menulis, memandu para peserta untuk mempelajari dan memahami KTI, 3) Penyuntingan, dengan memperbaiki tata bahasa, substansi materi dan lainnya, 4) Publikasi, KTI yang telah direvisi dipublikasikan pada jurnal ilmiah, 5) tahap monitoring dan evaluasi, yaitu tahap untuk memaparkan KTI hasil revisi kepada teman sebaya. Target luaran yang akan dicapai adalah 1) Karya Tulis Ilmiah yang telah disusun dan direvisi diupload di jurnal online maupun cetak, minimal jurnal nasional, 2) Menambah wawasan bagi guru tentang jurnal nasional, 3) mengajarkan guru lebih terampil dalam menyusun karya tulis ilmiah. Hasil dari kegiatan ini adalah berupa hasil konsultasi artikel, bagi para guru yang telah memiliki artikel penelitian dan feed back berupa tanggapan melalui instagram dengan hastag pgsd (#pgsdumg). Ketiga guru tersebut adalah Amelia Razanah dari SDN Tlogopatut, Ika Lufianah dari SDN Randuagung 2 dan Fatma hajar Islamiyah dari SDM GKB 2. Artikel yang dimiliki akan dipublish pada jurnal yang dikelola oleh prodi PGSD yaitu JTIEE pada volume yang akan ditentukan oleh pengelola jurnal. Harapan dari para peserta adalah kegiatan pelatihan semacam ini dilakukan rutin tiap semester agar bisa mendukung produktivitas dan perolehan jabatan fungsional guru untuk kenaikan jenjang karir.
Authors: Alfiansyah Iqnatia
Published: March 2022

Latar belakang penelitian ini yaitu rendahnya motivasi belajar yang dimiliki oleh mahasiswa pada saat pembelajaran di Universitas Muhammadiyah Gresik. Hal tersebut disebabkan karena proses pembelajaran yang monoton dan kurangnya pemanfaatan media pembelajaran. Tujuan penelitian ini adalah untuk meningkatkan motivasi mahasiswa terhadap pembelajaran. Penelitian ini menggunakan metode penelitian tindakan kelas yang menggunakan teknik analisis data deskriptif kualitatif dan kuantitatif. Instrumen yang digunakan adalah lembar angket respon mahasiswa. Peningkatan motivasi mahasiswa berdasarkan angket respon mahasiswa terhadap pembelajaran menunjukkan hasil yang baik, yaitu sebesar 88,6%. Kesimpulan dari penelitian ini adalah bahwa pemanfaatan media sampah sebagai bahan dasar kolase dapat meningkatkan motivasi belajar mahasiswa pada pembelajaran di Universitas Muhammadiyah Gresik.
Authors: Ailia Nia
Published: March 2022

Penelitian ini bertujuan untuk mengetahui efektivitas metode pemberian tugas secara daring dan jenis tugas secara daring yang diberikan oleh guru pada pembelajaran IPS kelas VA di SDN Poris Gaga 3 Kota Tangerang. Penelitian ini menggunakan metode kualitatif deskriptif. Pengumpulan data menggunakan metode wawancara, observasi dan dokumentasi. Teknik analisis data dengan menggunakan reduksi data, penyajian data dan penarikan kesimpulan. Hasil dari penelitian ini menunjukkan bahwa penggunaan metode pemberian tugas secara daring pada pembelajaran IPS kelas VA sudah efektif. Hal ini karena dengan pemberian tugas secara daring siswa lebih cepat dalam memahami materi yang disampaikan oleh guru, tercapainya tujuan pembelajaran serta pemberian, pengerjaan dan pengumpulan tugas dapat terlaksana dengan cepat. Pemberian tugas dapat pula melatih rasa tanggung jawab, kemandirian dan disiplin siswa dalam mengerjakan tugas yang diberikan guru. Jenis tugas yang diberikan oleh guru kepada siswa yaitu berupa lisan dan tulisan.