bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of In Vitro Effectiveness of Polymeric Nanoparticles Containing Clinoptilolit on Cryptosporidium Parvum
Authors: Karaoğlan Gamze , Ulutaş Bülent
Published: November 2023

Cryptosporidium species, which do not have a definite prevention and treatment protocol, are pathogenic protozoans that cause diarrhoea in humans and many animal species. This study aimed to demonstrate the in vitro efficacy of clinoptilolite polymer nanoparticle, which has known antidiarrheal effects. DNA isolation was made for species identification of Cryptosporidium oocysts obtained from faeces samples from naturally infected calves and lambs. RFPL analysis was performed in typing. For this purpose, nested PCR and SrpI, VspI and MboII enzymes were used. The coverslip surface was covered with 80% CaCo-2 cells and infected with 1x109 C. parvum. Nanoparticles containing 250, 500, 750 and 1000 μg/mL clinoptilolite were applied to infected cells. Percent of infection rate was calculated by counting under a fluorescent microscope following incubation. While the infection rate was 23.46% in the water-treated control cell group, the percentage infection rates in the clinoptilolite-containing nanoparticle treated group were respectively 15.60%, 8.13%, 10.33% and 13.46%. Inhibition percentages were determined as 33.54%, 65.56%, 55.99% and 42.66%, respectively. As a result, it was observed that the nanoparticle containing clinoptilolite had anticriptocidal activity in infection with C. parvum in Caco-2 cells. In addition, it was observed that the efficacy was dose-dependent, and the IC50 value was the most appropriate value at 750 and 1000 μg/mL doses.
Memorable gastronomic experience in sustainable tourism destinations: evidence from Croatia
Authors: Laskarin Azic Marina , Rašan Dora , Mikinac Krešimir
Published: November 2023

The aim of this study is to examine the nature of the relationship (direct and indirect) between perceived quality aspects (PQ), memorable gastronomic experiences (MGE) and tourist behavioral intentions (BI) in two sustainable destinations in Croatia - Istra and Međimurje. A sample of 414 respondents was collected through a questionnaire. To examine the relationships between PQ, MGE and BI, the primary data were then subjected to PLS-SEM analysis. The findings of this study indicate that a stronger direct relationship between MGE and BI was found in Istria compared to Međimurje. Moreover, among tourists who visited Istria, MGE proved to be a stronger moderator between local food (LF) and BI of tourists. By following the research results in both sustainable destinations, DMOs can create sustainable gastronomic routes with special attention to key elements of quality that promote the MGE.
Implementasi Model ATIK dalam Meningkatkan Kemampuan Kognitif Berbasis Proyek
Authors: Rodiah Siti , Watini Sri
Published: November 2023

Kemampuan kognitif merupakan aspek penting dalam pengembangan individu dan masyarakat. Model pembelajaran berbasis proyek telah diakui sebagai pendekatan yang efektif dalam meningkatkan kemampuan kognitif siswa. Salah satu kerangka pedagogis yang dapat digunakan untuk membimbing implementasi model pembelajaran berbasis proyek adalah Model ATIK (Amati, Tiru, dan Kerjakan). Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan kognitif siswa melalui pembelajaran proyek dengan Model ATIK. Model penelitian menggunakan quasi eksperimen melalui desain posstest-only control design. Sampel yang digunakan sebanyak 70 siswa TK Islam Assyifa, Johar Baru, Jakarta Pusat yang terbagi menjadi dua kelompok, yaitu kelompok kontrol (pembelajaran biasa) dan kelompok intervensi (pembelajaran menggunakan model ATIK). Setelah dikumpulkan, data akan dianalisis menggunakan uji mann whitney dengan bantuan perangkat Statistical Program for Social Science (SPSS). Hasil penelitian menunjukkan bahwa Penggunaan Model ATIK dalam pembelajaran menanam sayur dan membuat eco enzym di TK Islam Assyifa terbukti efektif dalam meningkatkan kemampuan kognitif siswa. Kelompok intervensi menunjukkan kemajuan yang lebih baik dalam aspek mengidentifikasi, menggambarkan, menerapkan, mendemonstrasikan, dan menghubungkan.
Internalisasi Akhlak (Studi Kasus di Pondok Pesantren Margasari Cijawura Kota Bandung)
Authors: Rosadi Umar , Permana Sandi Muhamad
Published: November 2023

Tujuan dalam penelitian ini adalah mengidentifikasi dan mendiskripsikan metode pembelajaran akhlak yang dilakukan Pondok Pesantren Margasari Cijawura. Pendekatan yang digunakan adalah kualitatif dengan metode studi kasus. Pengumpulan data dilakukan dengan studi dokumentasi, wawancara, dan observasi. Instrumen pengumpulan data yang digunakan berupa daftar pertanyaan, rekaman audio, kamera foto. Sumber data terdiri dari Kyai, ustad, santri, orang tua santri dan sumber lain yang mendukung. Data yang diperoleh dalam penelitian ini adalah proses internalisasi akhlak yang dilakukan pondok pesantren Margasari Cijawura melalui berbagai metode meliputi peneladanan, penegakan aturan, pemotivasian, pembiasaan, Pepujian, wiridan. Dampak dari kegiatan pembelajaran akhlak yakni adanya perubahan yang positif walaupun belum optimal seperti yang diharapkan karena materi, metode dan teknik pembelajaran akhlak yang dilakukan oleh Ustad Pondok Pesantren Margasari Cijawura masih mengikuti tradisi pondok pesantren. Untuk mencapai pembelajaran yang efektif dan efisien, direkomendasikan agar kyai, ustad dalam pembelajaran harus mempertimbangkan teori-teori pendidikan.
Pengaruh Pelatihan Kerja Kompensasi Finansial dan Pengembangan Karir terhadap Kinerja Karyawan
Authors: Suwidia I Putu , Ardani Wayan , Widani Made
Published: November 2023

The aim of this research is to determine the effect of job training, financial compensation and career development on employee performance at the CV Best Indonesian Gift Company. The method for determining the sample in this research is using saturated sampling (census). The total sample was 36 respondents. The data analysis techniques used in this research are Validity Test, Reliability Test, Classical Assumptions, and Multiple Linear Regression Analysis. The results of this study indicate that job training (X1), financial compensation (X2), and career development (X3), is assumed to be equal to 0 (zero), then employee performance (Y) will increase. The results of this study indicate that job training (X1), financial compensation (X2), and career development (X3) is assumed to be equal to 0 (zero), then employee performance (Y) will increase. Test the significance of multiple correlation using the F test, simultaneously job training, financial compensation and career development have a positive and significant effect on employee performance. The significance test uses the t test, partially job training, financial compensation and career development have a positive and significant effect on employee performance at the CV Best Indonesian Gift Company.
Benefits of Huangqi Herbal Treatment for Patients with Diabetes Mellitus
Authors: Theresia Maria , Priskila Onny , Mellisa Mellisa , Aldo Alfredo , Purnomo Evelyn
Published: November 2023

Introduction: Diabetes mellitus (DM) is a metabolic disorder caused by abnormalities in insulin secretion and an imbalance between insulin supply and demand. In Traditional Chinese Medicine (TCM), diabetes mellitus is better known as Xiao Ke. In TCM, Xiao Ke disease is caused by internal heat exhaustion deficiency, and one of the traditional treatments for diabetes is the herbal Huang Qi (Radix astragali). Method: This research is a case study, where the researcher makes an in-depth observation of the use of Huang Qi herbs in diabetes mellitus patients. Result and Discussion: The results of diabetes treatment in the initial observation of the patient's blood sugar were 152 mg/dL, and in week 4, it decreased to 86 mg/dL. Isoflavonoids, saponins, and polysaccharides are the three main types of beneficial compounds that have pharmacological activity and therapeutic efficacy in many diseases, one of which is diabetes. In TCM, Huang Qi is beneficial for tonifying Qi and strengthening Yang in spleen Qi deficiency so that the spleen can increase its effectiveness in transformation and transportation. Conclusion: The results of the treatment of diabetes mellitus, or Xiao Ke, using Huang Qi herbs are proven to be able to reduce blood sugar levels in diabetics.
The Relationship Between Personal Factors of Mothers Under Five and The Incidence of Stuntinging in Toddlers (24-59 Months)
Authors: Meylani Meylani , Astuti Siregar Sri , Rahayu Ningsih Vinna , Mawarti Perdana Silvia , Wisudariani Evy
Published: November 2023

Introduction: Stunting is a chronic nutritional problem caused by multi-factorial and intergenerational with causative factors such as malnutrition experienced by mothers during pregnancy, poverty, underage maternal pregnancy, IUGR, premature or premature birth, and babies born with low birth weight. Objective: This study aims to determine the relationship between the history of Chronic Energy Deficiency (CED) and Anemia in mothers under five with the incidence of stunting in toddlers (24-59 Months) in Sungai Mengkuang Village, Bungo Regency in 2022. Method: The type of research is quantitative  with a cross sectional design, with a population of all mothers under five in Sungai Mengkuang Village, with sampling techniques using Purposive sampling techniques. The data obtained were analyzed by the Chi-Square test. Result and Discussion: The Chi-square test shows that there is a relationship between the history of CED, Anemia, Knowledge, and Parenting in mothers under five with the incidence of stunting in toddlers (24-59 months) in Sungai Mengkuang Village in 2022 with P-Value values of 0.001, 0.006, 0.012  , 0.002 respectively and there is no relationship between the attitude of mothers under five towards CED and anemia with the incidence of stunting in toddlers (24-59 months) in Sungai Mengkuang Village in 2022 (P-Value 0.606). Conclusion: In this study, there is a relationship between CED, anemia, knowledge, and parenting with the incidence of stunting in toddlers (24-59 months) in Sungai Mengkuang Village in 2022, and attitudes are not related
The Effect of Playing Plasticine on the Fine Motor Development of Children Aged 4-6 Years in Kindergarten
Authors: Safari Ganjar , Al Syurfah Zein , Yusfar KM , Pujiastuti Liana
Published: November 2023

Introduction: Fine motor development in children aged 4-6 years is able to use scissors correctly, write numbers, letters, draw body parts. However, the facts in the field, especially in Widuri Kindergarten, SKB Playschool, Mawar Putih Playschool, there are still many children aged 4-6 years who are not able to hold a pencil properly, have not been able to hold scissors and hold the crayon correctly and even draw body parts are not able to cause problems with children's fine motor development that is slow and causes obstacles to children in completing their tasks. Objective: The purpose of this study was to determine the effect of playing plasticine on fine motor development of children aged 4-6 years kindergarten in Baleendah Village, Bandung Regency. Method: The method used in this study is with experimental methods with Quasi Experimental Design research design. Result and Discussion: The statistical test in this study is Mc Nemar obtained results with p-value (Asymp. Sig 2 tailed) of 0.0001 < 0.05, it can be concluded that there is an effect of playing plasticine on fine motor development in children aged 4-6 years kindergarten in Baleendah Village, Bandung Regency. Conclusion: Through this study there are results that playing plasticine has an influence on children's fine motor development, therefore it is hoped that learning methods by utilizing plasticine play can be applied in kindergartens in Baleendah Village
Association of Exclusive Breastfeeding to the Prevention of Precocious Puberty
Authors: Tjahyanto Teddy , Angellina Mulyadi Eunike , Angelica Novian Gabriel , Rianto Louis
Published: November 2023

Introduction: Exclusive breastfeeding is breast milk given without other foods to children up to 6 months of age. Breast milk has many uses, including helping children's growth and development, preventing infections, reducing the risk of obesity, and helping children's mental and psychomotor development. Exclusive breastfeeding was found to have a protective effect against the incidence of precocious puberty. Precocious puberty is defined as the onset of puberty that occurs before age 8 in girls and age 9 in boys.  Objective: Based on these findings, the authors want to make a study to compile the latest research results on the association of exclusive breastfeeding as one of the prevention of precocious puberty.  Method: The author searches, selects, and selects journals related to exclusive breastfeeding with the prevention of precocious puberty through several research databases including ScienceDirect, Google Scholar, PubMed, and Wiley. The keywords used are "exclusive breastfeeding", "precocious puberty", and "prevention".  Results and discussion: Various studies have shown that exclusive breastfeeding has a protective effect against the incidence of precocious puberty. Exclusive breastfeeding alone can reduce the risk of obesity in children. Obesity in this child, based on several studies, is a risk factor for precocious puberty. Conclusion: Exclusive breastfeeding of children can prevent the incidence of precocious puberty.
Multiparity In Timor-Leste, Risk Factor Associate the Midwife Intervention in Center Health of Community Ainaro Timor-Leste
Authors: Carvalho de Araujo Eugenia , Da Costa Monteiro Ermelinda , Pereira Natalia , De Deus Elisa , Jose Tilman Etelvina
Published: November 2023

Introduction: East Timor has changed dramatically. Since its independence just a decade ago, it has a post-conflict country to a developing country to lower middle-income. As the country experienced the socio-economic progress and security in recent years, multiparity situation in Timor-Leste has also gradually improved. However, there are several challenges that still affect many children born in the same family in East Timor. The analysis of the overall situation of the family having many children is imperative to ensure evidence-based actions to address the remaining challenges in the country's changing context. Objective: The objective of this thesis is to know the factors of multiparity; Identify the knowledge of women about the risk of multiparity; Knowing what the perception of women on the intervention of the midwife in the risk of Multiparity. Method: This research is a study of exploratory and descriptive. The sample is composed of 30 pregnant women who attended antenatal Ainaro Health Center in the central part of East Timor. The data collection collected in the period from 5 October to 6 November 2015. Result and Discussion: Multiparity provides strong reasons such as assisting a family continuation of generations, care for the parents when they are elderly. Conclusion: This study indicates that, although few women in Ainaro district are aware that there are dangers associated with high birth, but most of our respondents do not think that there are health risks associated with having many children. With their education, they think that high birth women feel that having many children was harmless to your health. This number is significant, considering the implications of high parity on maternal and neonatal morbidity and mortality and long-term, socio - economic. This is more so when viewed considering a total of high fertility in East Timor in an economy that is not developed
Evaluation of loss of earning power in pneumoconiosis patients with occupational lung disease
Authors: Tetik Yusuf , Sogukpinar Veysel , Icmeli Ozlem , Altin Sedat
Published: November 2023

Occupational diseases are a category of diseases that are caused by exposure to risk factors. Pneumoconiosis is one of the occupational diseases. We aimed to analyze patients with pneumoconiosis whose diagnosis was finalized by the 3rd Forensic Medicine Specialization Committee (3rd FMSC) of the Forensic Medicine Institute (FMI). The study investigated various factors such as gender, diagnosis age, length of employment, workplace measurements of the causative agent, smoking history, pneumoconiosis subtypes, opacity types, Pulmonary Function Test (PFT) values, as well as decisions made by the Occupational Diseases Hospital (ODH), Social Security Institution (SSI), and Social Insurance High Health Board (SIHHB). Retrospective analysis was conducted on 369 patients with pneumoconiosis that received disability determination. All patients were male, with mean age at initial diagnosis of 44.25±11.86 years. The mean duration of occupational exposure was 16.32±7.54 years. Silicosis was the most common diagnosis. Occupational diseases were diagnosed in 95.7% of patients by the 3rd FMSC, with small opacity being the most prevalent subtype, particularly q2-p1 opacity among them, and B opacity being the most common among large opacities. Significant correlation was found between working hours and types of pneumoconiosis. However, no significant correlation was found between radiologically determined opacities by the 3rd FMSC and working duration. Examination of the decisions made by the 3rd FMSC, SIHHB, SSI, and ODH revealed the least agreement between ODH and other institutions. Regarding the diagnosis agreement of opacity densities between the 3rd FMSC, SIHHB, SSI, and ODH, the agreement between the 3rd FMSC and other institutions was the lowest. To evaluate disability caused by pneumoconiosis, it is recommended to utilize current technological advancements and provide comprehensive medical documentation. In the relevant regulations, it is suggested that a new regulation, involving branch specialists, should be developed to address the radiological, functional, and clinical aspects in comprehensive manner.r.
Homestay Tourism and Sustainable Development in the Indian Himalayan Region: Prospects & Challenges
Authors: Dr. Prithvi Raj Sanyal  , Sunita Kumari  , Dr. Gulnaz Siddiqui
Published: November 2023

In developing countries like India, homestay tourism is a relatively a new concept that has been introduced in the field of tourism and travel. It has number of benefits at social, economic and environmental level and simultaneously, it has certain limitations also. Purpose of this research paper is to evaluate the social, economic and environmental issues of homestay in Indian Himalayan Regions so that various tourism policies can be framed. Another purpose is to decide whether homestay is good & safe for an individual as a host and as a guest. Future potentials of home stay tourism has also been highlighted in the present paper and it also carry number of challenges faced by homestay tourism. Some proposed measures to improve homestay tourism have been given. It has been linked with sustainable development also. As per the expectations of the author, the present paper is going to give a lot of ideas & benefits to not only those people who are connected with tourism and travel but it will also give an idea to the govt., environmentalist, young generation, gen-z (specially residing in Himalayan region), spiritual and religious organisations, people interested in knowing the traditions and culture of other regions and to both guest and host community. The focus of the paper is empowering local and rural communities towards homestay tourism and preserving heritage culture of the people residing in Indian Himalayan Regions. Various marketing strategies to promote home stays has also been highlighted in this paper.
A Study on Impact of Foreign Direct Investment and its Challenges Post Liberalization
Authors: Dr. Prithvi Raj Sanyal  , Sunita Kumari  , Dr. Kartikey Bhardwaj
Published: November 2023

In the beginning of liberalization when India was facing the financial crises for meeting the external commitments, during the Prime minister Chandra Sekhar government, India had to pledge its gold before World Bank to repay the foreign debts as India had only $ 1 billion foreign exchange reserves, at the same time, the immediate external payment was more than $ 25 billion. Therefore, India was bound to opt for liberal economic policy for the inflow and outflow of foreign investment and depreciation of Indian rupees by 300% in comparison of dollar from rupees 8 to rupees 28 per dollar. By which the foreign investors started attracted and investing their funds in India, as the India had and has potential for the growth and diversification of business, since then the India has made remarkable progress in the field of foreign direct Investment but there are lot many challenges and issues needs to be resolved to promote and attract foreign direct investment. The following issues and challenges are listed in the papers: lack of transparent and specific  sectoral FDI policy and a limited FDI regime Contributing  factors include high tariff rates compared to international standards, a lack of state government decision making power, a limited number of export processing zones, the absence of exit barrier liberalization, stringent labor laws, financial sector reforms, fluctuating exchange rates, and unclear political leadership. In this post, the authors have made an effort to update the best and most plausible conclusions for the justification of foreign direct investment.
EFICÁCIA DE CONTROLE DO HERBICIDA FALCON PIROXASULFONA + FLUMIOXAZINA) EM APLICAÇÕES EM PRÉ-EMERGENTE DAS ESPÉCIES Cyperus rotundus E Cyperus esculentus
Authors: Araújo Aníbal Pelicía , Corrêa Pedro Henrique Alves , da Silva Danilo Carvalho Pereira , Viana Everton Sousa , Corrêa Marcelo Rocha , Negrisoli Eduardo
Published: November 2023

O ensaio foi realizado na estação experimental TechField, localizada no município de Botucatu/SP, com a finalidade de avaliar a eficácia de controle das espécies Cyperus rotundus e Cyperus esculentus, em aplicações em pré-emergente do herbicida Falcon (piroxasulfona+flumioxazina). As espécies avaliadas foram plantadas em vasos contendo 20 litros de solo, mantendo-se 10 tubérculos por vaso de ambas as espécies. Utilizou-se o delineamento experimental inteiramente casualizados com cinco tratamentos e sete repetições, sendo assim distribuídos: 1) Testemunha sem aplicação; 2) Falcon – 0,25 L p.c. ha-1; 3) Falcon – 0,5 L p.c. ha-1; 4) Falcon - 1,0 L p.c. ha-1 e 5) Falcon – 2,0 L p.c. ha-1. A aplicação dos tratamentos, ocorreu no dia 17/04/2021, com auxílio de um pulverizador costal pressurizado com CO2, munido de barra composta por duas pontas AVI 110.02, espaçadas em 0,5 m entre si, a uma pressão de 2,0 kgf cm-2, proporcionando um consumo de calda equivalente a 200 L ha-1. As avaliações de eficácia de controle foram realizadas aos 14 dias após aplicação (DAA), 21DAA, 28DAA, 35DAA e 42DAA. Considerando as variáveis no desenvolvimento das plantas daninhas avaliadas, realizou-se a avaliação de número e peso dos tubérculos remanescentes, aos 100DAA, no dia 26/06/2021. De acordo com os resultados obtidos, as maiores porcentagens de controle foram observadas quando aplicado as três maiores doses do herbicida Falcon (0,5, 1,0 e 2,0 L p.c. ha-1), independente do período e espécies avaliadas. Nas avaliações de número e peso dos tubérculos remanescentes, pode se concluir que a menor dose do herbicida Falcon (0,25 L p.c. ha-1), juntamente com o tratamento testemunha, apresentaram valores muito superiores aos demais tratamentos testados, demostrando assim o efeito positivo do herbicida sobre as espécies avaliadas. Os melhores resultados de redução de número e peso de tubérculos foram observados quando aplicado as duas maiores doses do herbicida Falcon (1,0 e 2,0 L p.c. ha-1), independente da espécie de planta daninha avaliada.
Transformation of Rural Communities in Parigi Moutong Regency
Authors: Alimuddin
Published: November 2023

The purpose of this research is to find out about the process of transforming rural communities, forms of multi-actor intervention in rural transformation construction and new capacities for rural development in Parigi Moutong. This type of research is research using a qualitative research method approach as a research procedure that produces descriptive data in the form of written or spoken words from people and observable behavior. This approach is directed at the setting and the individual holistically (whole), in this case individuals or organizations cannot be separated into variables or hypotheses and need to view them as part of a whole. The results showed that in the process of community transformation underwent two categories, slow and fast, which were conditioned by several of them: 1) socio-cultural background factors, 2) economic factors of property ownership, 3) political factors of power. Technological factors in the utilization of production resources. The form of intervention is seen in the community itself which is related to their daily lives with work ethic capital, government and entrepreneurs who have interests. The transformation process still has a gap between the indigenous population and the immigrant population.
THE INFLUENCE OF WORK ETHIC AND ORGANIZATIONAL COMMITMENT ON EMPLOYEE PERFORMANCE AT PT. BTN (PERSERO) MEDAN BRANCH OFFICE
Authors: Nainggolan Mina Indryani , Siregar Onan Marakali
Published: November 2023

This study aims to analyze the influence of work ethic on employee performance, ascertain the impact of organizational commitment on employee performance, and determine the combined influence of work ethic and organizational commitment on employee performance. The research is of a quantitative nature with an associative approach. The study's population consists of employees at PT. Bank Tabungan Negara (Persero) Tbk Medan Branch Office. Simple random sampling was employed to select a sample of 61 respondents. The findings reveal that the work ethic variable (X1) significantly affects employee performance, as does organizational commitment (X2). Work ethic and organizational commitment collectively influence employee performance. The determination test yielded a correlation coefficient (R) value of 0.661, indicating a relatively strong relationship between work ethic, organizational commitment, and employee performance. The adjusted R-square value, or coefficient of determination, suggests that 41.7% of employee performance variance can be explained by work ethic and organizational commitment variables, while the remaining 58.2% is influenced by other unexamined variables.
Sàng lọc in silico các chất ức chế Mpro ở SAR-CoV-2 từ quả cà dại hoa trắng Solanum torvum Sw. Solanaceae
Authors: Phan Vy Thiện , Nguyễn Vy Vũ Thụy , Lư Giàu Bích Ngọc
Published: November 2023

Các biến thể SARS-CoV-2 mới làm gia tăng tình trạng lây nhiễm, đồng thời làm giảm hiệu quả của vaccine và thuốc điều trị. Quả Solanum torvum được chứng minh có tiềm năng kháng virus. Sàng lọc ảo nhằm tìm kiếm các hợp chất kháng SARS-CoV-2 từ quả S. torvum là con đường hiệu quả giúp tiết kiệm thời gian và chi phí. 91 chất đã được công bố có trong quả S. torvum được tiến hành docking trên protease chính Mpro (6LU7). 5 chất có điểm số docking tốt nhất là quercetin, torvanol A, rutin, acid clorogenic và acid 4-O-caffeoyl quinic. Mô phỏng động lực học phân tử (MD) trong 50 ns cho thấy quercetin và acid clorogenic có khả năng gắn kết tốt vào Mpro (DGbind là −18,02 và −16,51 kcal/mol, tương ứng). Đánh giá ADMET cho thấy hai chất này ít độc tính và thích hợp dùng đường uống. Mô hình docking phân tử và mô phỏng MD đã xây dựng có khả năng sàng lọc tốt các chất ức chế Mpro, phù hợp với các nghiên cứu trước đây và có thể ứng dụng trong sàng lọc các hợp chất tự nhiên.

® 2023 Journal of Science and Technology - NTTU
Xây dựng qui trình định lượng đồng thời methylparaben và propyl-paraben trong kem bôi da bằng phương pháp sắc kí lỏng hiệu năng cao
Authors: Mai Nhàn Thanh , Nguyễn Thảo Thị Thu
Published: November 2023

Các chất bảo quản methylparaben và propylparaben được dùng chủ yếu trong dược phẩm và mĩ phẩm. Tuy nhiên, việc kiểm soát các chất bảo quản là cần thiết, do các chất bảo quản này cần được sử dụng trong nồng độ cho phép để đảm bảo sự an toàn của người tiêu dùng. Nghiên cứu nhằm mục đích đưa ra qui trình định lượng đồng thời methylparaben và propylparaben trong kem bôi da bằng phương pháp sắc kí lỏng hiệu năng cao. Qui trình gồm các bước hòa tan mẫu trong ethanol:H2O (70:30, v/v) và định lượng bằng phương pháp sắc kí lỏng hiệu năng cao, sử dụng cột RP–18 (250 mm × 4,6 mm × 5 µm), đầu dò photo diode array (PDA) với bước sóng phát hiện 256 nm, pha động methanol:đệm kali dihydrophosphat (65:35, v/v). Phương pháp phân tích có độ đặc hiệu, độ tuyến tính, độ đúng và độ lặp lại đạt yêu cầu theo hướng dẫn nội dung và phương pháp của Hội nghị Hài hòa Quốc tế (International Conference on Harmonization – ICH). Phương pháp này phù hợp để phân tích các loại kem bôi da có chứa thành phần chất bảo quản methylparaben và propylparaben.

® 2023 Journal of Science and Technology - NTTU
Technical report. Equations for improving the accuracy of Decagon MPS-2 matric potential readings in dry soils
Authors: Walthert Lorenz , Cobos Douglas R. , Schleppi Patrick
Published: November 2023

Soil matric potential quantifies water availability in soils. Low soil matric potentials are difficult to measure with most in situ techniques. This is also the case for the widely-used dielectric MPS-2 sensor. This probe determines matric potential indirectly from the measured water content in its porous sensor ceramics using dielectric permittivity as a proxy for water content. The accuracy of MPS-2 readings was analyzed in desiccation experiments using 13 soils with different texture and organic carbon content and a WP4C dewpoint potentiometer as reference instrument. Further, it was explored whether observed inaccuracies relate to sensor calibration, confounding dielectric effects, or the water release characteristics of the sensor ceramics. Above -1000 kPa, the MPS-2 readings were accurate in all tested soils with a mean deviation of 3% to the reference values. Below -1000 kPa, MPS-2 readings were increasingly higher than the reference in all tested soils, but the deviation from the reference depended on soil type. Poor factory calibration of the sensors, soil texture dependent differences of water flow at the soil-ceramic interface, and dielectric effects are supposed to be the main reasons for the low and soil-type-specific MPS-2 sensor accuracy in dry soils. Nevertheless, the high consistency of the MPS-2 readings allowed us to derive soil-type-specific equations to improve the accuracy of measurements to values as low as -4000 kPa. We recommend applying the equations to any MPS-2 readings below ~ -1000 kPa to obtain more reliable data and thus an improved insight into the role of soil water in ecosystems.
АЙДАР-АРНАСОЙ КЎЛЛАР ТИЗИМИ ТАЪСИРИДА АТРОФ-МУҲИТ ЛАНДШАФТЛАРИНИНГ ЎЗГАРИШИ
Authors:   ЖДПУ География ва иқтисодий билимлар асослари  кафедраси мудири, доцент, Миркомил Ғўдалов
Published: November 2023

In this following article you can find history of the Aydar-Arnasay lakes system and changes of lake water volume which is learned effects of environmental landscapes.
Damage to palletized loads in road transport
Authors: Tkaczyk Sławomir , Szpotański Mariusz
Published: November 2023

Manufacturers and operators of the logistics market are constantly looking for ways (opportunities) to reduce the costs of their operations. This also applies to all types of packaging. A conflict arises here between manufacturers and carriers. Producers will try to reduce the costs of collective packaging as much as possible (this packaging does not affect customers’ purchasing decisions), while for transport operations, this packaging will determine the safety and quality of transported cargo. Preparing the load for transport - properly selected packaging (its shape, resistance to pressure, etc.), and above all, the proper way of forming and securing PSU (pallet load units) is a very important issue for the manufacturer/sender (as the first link in the distribution chain). It has a huge impact on the formation of cargo damage during its transport. As part of the research conducted by the authors in the area of optimization of cargo securing costs and minimization of cargo damage, the lack of a systemic approach to the problem of cargo damage in road transport was observed. The article discusses the causes of damage to palletized loads during road transport and illustrates some of these damages. Identification of the causes of damage made it possible to classify damage to palletized loads, and in the future, it will allow the development of ways to limit them, the so-called good practices for securing palletized loads.
Identification of promising sunflower (Helianthus annuus L.) inbred lines for oil and quality parameters
Authors: PRADUMAN YADAV  , H P MEENA  , K S V P CHANDRIKA  , A VISHNUVARDHAN REDDY
Published: November 2023

Improvement of oil content and oil quality are the major goals in sunflower research. In the present study, a setof 60 sunflower inbred lines were evaluated for oil content and fatty acid profile. Oil content in the inbreds, rangedfrom 28.13 (GPR-58) to 41.03% (RHA-6D-1 and AKSFI-42-1). Nine inbred lines showed more than 38 percent oilcontent and one line showed high linoleic acid content of 70.2% (RHA-272). Two other inbred lines viz., AKSFI-52-2 (10.47%) and CSFI-5033 (10.27%) recorded high stearic acid content.
Comparative genomics studies of Rpp1 gene associated with soybean (Glycine max L.) rust resistance
Authors: MILIND RATNAPARKHE  , SHIVAKUMAR M  , NATARAJ V  , VIRAJ KAMBLE  , SANJAY GUPTA
Published: November 2023

Whole genome sequence of rust resistant and susceptible lines were used for comparative genomics studies.Three putative NBS-LRR genes were identified at Rpp1 locus associated with soybean rust.
Correlation studies for quantitative traits in sesame (Sesamum indicum L.)
Authors: S M UMATE
Published: November 2023

The genetic variability could be determined with the help of genetic parameters such as genetic coefficient ofvariation, heritability estimates and genetic advance. The present investigation was therefore planned to evaluatedifferent germplasm lines of sesame with objectives to study the genetic variability and correlation. The observedvariability in the chosen 20 genotypes of sesame could be partitioned into heritable (genetic) and non-heritable (nongenetic) components.
Morphological evaluation and comparative study of pollen viability of different promising genotypes of sesame (Sesamum indicum L.)
Authors: ADIL IQBAL  , JHILIK CHOWDHURY  , TAMINA BEGUM  , TAPASH DASGUPTA
Published: November 2023

The present investigation was carried out to evaluate 21 genotypes of sesame on the basis of 8 morphologicalcharacters to assess the pollen viability of the selected promising genotypes as well the ideal time for maximum pollen viability. Pollen viability was assessed at three different times, viz., 7.45 a.m., 11.00 a.m. and 12.45 p.m. Based on morphological characters all the genotypes were grouped into 3 major clusters. Depending upon genetic distance seven promising genotypes were selected from different clusters for future crossing program. The average pollen viability of these seven promising parents was 85.57% at 7.45 a.m. followed by 72.55% at 11.00 a.m. and 63.84% at 12.45 p.m. Maximum pollen viability was observed in the morning hours i.e. at 7.45 a.m. Interestingly, out of the selected genotypes, the wild species, Sesamum mulayanam showed significantly more pollen viability percentage (96.61%) at 7.45 a.m. as compared to the genotypes belonging to the cultivated species, indicating its potential as a good pollinator.
India’s first high oleic safflower variety for commercial cultivation
Authors: ANJANI KAMMILI  , PRADUMAN YADAV  , A VISHNUVARDHAN REDDY
Published: November 2023

Indian safflower varieties possess low oleic acid content (16-20%). Therefore, high oleic (>70%) safflower oil isimported from abroad to meet the domestic needs. ICAR-Indian Institute of Oilseeds Research developed India’s first high oleic safflower variety, ISF-1, which has been notified recently for all India cultivation. ISF-1 contains 76% oleic acid and 31% oil. It gives four-fold higher oleic acid yield (4.41 q/ha) than the leading variety, PBNS-12 (1.0 q/ha). Its performance with respect to oleic acid content and seed and oil yield in AICRP (Safflower) trials and in farmers’ fields across the country is presented in this paper.
Effect of EMS on seed germination in white seeded sesame varieties (Sesamum indicum L.)
Authors: V SANDHIYA  , M KUMAR  , C PARAMESWARI  , ANAND M BADIGANNAVAR
Published: November 2023

In the present investigation, two white seeded sesame varieties VRI 3 and SVPR 1 were treated with sevendifferent concentrations of EMS. Germination percentage and germination index were tested using two differentgermination methods. Seed germination decreased with increased concentration of Ethyl Methane Sulphonate (EMS) in both the varieties. For fixing the lethal dose for the chemical mutagen Pro tray method of germination test was found reliable than germination paper method.
Genetic variability for key physiological traits in groundnut under managed drought condition
Authors: B N HARISH BABU  , G CHANDRASHEKHARA  , S K PATTANASHETTI
Published: November 2023

Drought is a major production constraint in rainfed groundnut. In the present study, genetic variability forrelative water content (RWC) of leaf, membrane stability index (MSI), SPAD chlorophyll meter readings (SCMR) and percent wilted plants was assessed in 40 advanced breeding lines of groundnut under managed drought condition. Significant differences were noticed for key physiological traits. The RWC of leaf, MSI and percentage of wilted plants under drought showed high GCV, PCV, heritability coupled with high genetic advance over mean. The SCMR showed lower GCV and PCV but exhibited high heritability with moderate genetic advance over mean indicating the possibility to improve this trait by proper selection methods.
Studies on genetic variability, correlation coefficient and path analysis in niger (Guizotia abyssinica L. Cass)
Authors: S S ATLAWAR  , V N TOPROPE  , R J SHINDE
Published: November 2023

Analysis of variances indicated the presence of substantial amount of genetic variability in the genotypes for allthe characters. The GCV and PCV were of high magnitude for the character number of capitula/plant followed by number of seeds/capitulum, number of secondary branches/plant and harvest index. The estimate of high heritability coupled with high genetic advance as per cent of mean has been noticed for number of capitulum/plant, number of seeds/capitulum, number of secondary branches/plant, harvest index, number of primary branches/plant, seed yield/plant, oil content and 1000 seed weight indicating the pre dominance of additive gene action in there expressions. Seed yield exhibited positive significant association with 1000 seed weight, number of capitulum/plant, number of seeds/capitulum, number of secondary branches/plant and harvest index.
High zinc density groundnut cultivars: A solution to Zn malnutrition
Authors: A L SINGH  , V SUSHMITA CHAUDHARI  , C B PATEL
Published: November 2023

Analysis of a number of groundnut cultivars for several years showed variation in Zn concentration in seedwith year, field and crop responsiveness to Zn fertilizers. Its concentration ranged from 21 to 67 mg/kg with a mean value of 42 mg/kg and with application of 1-2 kg Zn, increased to 24-78 mg/kg with a mean of 49 mg/kg. Twenty high Zn density groundnut cultivars with more than 50 mg/kg were identified for use as food.
Response of castor (Ricinus communis L.) to polymeric bio-formulation based seed coating for drought stress
Authors: K S V POORNA CHANDRIKA  , M BHASKAR REDDY  , P LAKSHMAMMA  , R D PRASAD  , VARSHA GODBOLE
Published: November 2023

Polymer based bio-formulations for seed treatment is one of the strategies to mitigate drought stress. Droughttolerant strain of Trichoderma asperellum N13 (TN13) along with polymers was evaluated in castor under droughtconditions in both glass house and field.
Nitrogen and sulphur requirements of shattering tolerant canola oilseed rape (Brassica napus L.) under varied plant population
Authors: VIRENDER SARDANA  , S S BANGA  , GURPREET KAUR  , PUSHP SHARMA
Published: November 2023

The study was conducted during rabi 2018-19 to study about the row spacing, nitrogen and sulphur requirements of shattering tolerant oilseed rape. Row spacing of 30 cm resulted in 12.7 and 12.6 % higher seed (2819 kg/ha) and oil (1066 kg/ha) yield than 45 cm row spacing. Application of 100 kg/ha of N significantly increased the seed yield by 11.8% and oil yield by 11.9% over 75 kg/ha of N. Application of 40 kg/ha of S increased the seed and oil yield by 3.8% and 4.5%, respectively over 20 kg/ha of applied S. Interactions between different treatments for different traits were non-significant.
The agro-morphological characterization of castor (Ricinus communis L.) inbred lines
Authors: YAMANURA  , R MOHAN KUMAR
Published: November 2023

Thirty six castor inbred lines were studied for agro-morphological characterization, the entire group of inbredlines showed wide range of genetic variation for qualitative traits like anthocyanin pigmentation on hypocotyl and younger leaves, bloom/waxiness, stem colour, types of internodes on main stem, leaf shape, petiole surface, types of flowers on primary spike, spike shape, spike compactness, spines on capsules, location of branches, branching pattern, seed shape, seed coat colour, seed mottling and seed caruncle and quantitative traits like days to 50% flowering, plant height, primary spike length, no. of nodes to primary raceme, 100 seed weight. The hypocotyl anthocyanin pigmentation showed close association with presence of anthocyanin pigmentation on young leaves. About 97% of inbred lines exhibited double bloom nature which is an important trait for drought tolerance in castor.
Effect of potassium on growth, yield and economics of safflower (Carthamus tinctorius L.)
Authors: K C OMBASE  , S V KHADTARE  , S K SHINDE  , L N TAGAD  , D R MURUMKAR  , H N AIWALE  , V B AKASHE
Published: November 2023

Field experiment was conducted for ascertaining the response of safflower to different levels of potassium forthree years in post rainy season from 2016-17 to 2018-19. The experiment consisted of five treatments viz., 0, 20, 30, 40 and 50 kg/ha K2O with four replications in RBD. Potassium application @ 50 kg/ha recorded significantly higher seed yield than 40 kg/ha. Plant height and 100- seed weight were also significantly influenced due to potassium.
Enhancing the productivity of wheat + mustard intercropping system with different row proportions and nutrient management practices
Authors: T SUDHA  , K SHIVAPPA
Published: November 2023

The effect of row ratios and nutrient management practices in wheat-mustard intercropping system was studiedto optimize row ratio and nutrient management practice. Intercropping system wheat + mustard in 5:1 row proportion with 125% recommended dose of fertilizer (RDF) recorded significantly higher seed yield, land equivalent ratio, area time equivalent ratio and net returns.
Optimization of seed rate and spacing in soybean (Glycine max L.)
Authors: D K KATHMALE  , R N PALVI  , S B MAHAJAN
Published: November 2023

To optimize seed rate and plant spacing in soybean an experiment was conducted with four plant spacings andthree treatments of number of seeds dibbled. Sowing of soybean at 45 x 5 cm plant spacing with single seed dibbling (50 kg seed/ha) was beneficial for higher yields and economic returns in soybean.
Response of sunflower (Helianthus annuus L.) based cropping systems to fertilizer levels
Authors: D SWETHA  , A V RAMANJANEYULU  , D SRAVANTHI  , N SAINATH
Published: November 2023

Field experiment was conducted during 2018-19 to study the effect of different preceeding crops and fertilizerlevels on yield and economics of rabi sunflower. Significantly higher sunflower equivalent yield was obtained inmaize-sunflower cropping system (2071 kg/ha) which is on par with greengram-sunflower cropping system (2060 kg/ha). Application of 100% RDF recorded significantly higher sunflower equivalent yield (1785 kg/ha) than 50% STCR (1428 kg/ha) but on par with that of 100% STCR (1650 kg/ha). The highest system gross returns, net returns and B: C ratio were obtained with greengram-sunflower and 100% RDF fertilizer.
Performance of soybean (Glycine max L.) genotypes under delayed monsoon conditions in transitional tract of Dharwad
Authors: BOMNGAM KARLO  , J A HOSMATH
Published: November 2023

The experimental results indicated that genotype DSb-32 recorded significantly higher seed yield (25.04 q/ha)and B:C ratio (2.75) concluding that the genotype DSb-32 proved superior under delayed onset monsoon conditions for realizing optimal yield and returns.
Seed and petal yield of non-spiny cultivars of safflower (Carthamus tinctorius L.) under rainfed conditions
Authors: P PADMAVATHI  , PRADUMAN YADAV
Published: November 2023

Eight non-spiny cultivars were evaluated under rainfed conditions during the post rainy season of 2012-13 for their seed and petal yield in comparison to two spiny cultivars. Spiny cultivars gave significantly greater yields (1515 kg/ha) compared to non-spiny cultivars (911 kg/ha). Among the non-spiny cultivars NARI-NH-1 and NARI-6 (1175 kg/ha) were significantly superior over other non-spiny cultivars (823 kg/ha).
Impact of foliar spray of nutrients seed yield and economics of soybean (Glycine max L. Merrill)
Authors: SREEDHAR CHAUHAN  , K SUKUMAR  , M RAJENDAR REDDY
Published: November 2023

Soybean yield was significantly influenced by the foliar spray of nutrients and highest yield was recorded with RDF+19-19-19 (NPK) @ 2% foliar spray at pod initiation stage (3132 kg/ha) which was on par with RDF+DAP @ 2%foliar spray (2976 kg/ha). But, highest net returns and B:C ratio was recorded with RDF+urea @ 2%.
Efficacy of insecticides against groundnut defoliators, Helicoverpa armigera (Hubner) and Spodoptera litura (F.)
Authors: D M JETHVA  , J B BHUT
Published: November 2023

Among insect pests, lepidopteron defoliators viz., Helicoverpa armigera and Spodoptera litura are the most serious problems in groundnut crop. The present study was undertaken to test the effectiveness of some newer molecules against these pests in groundnut. Looking to the efficacy, yield and economics of the treatments indoxacarb 14.5% SC 0.007%, chlorantraniliprole 18.5 SC 0.006% and spinosad 45 SC 0.014% were the most effective and economic insecticides for the management of H. armigera and S. litura in groundnut.
Management of safflower aphid through seed treatment and foliar sprays
Authors: P S SRINIVAS
Published: November 2023

Seed treatment with either thiamethoxam 30FS @ 10 ml/kg (4.6-5.2 aphids/5cm twig/plant) or imidacloprid 600 FS @ 8 ml/kg (1.1-2.1 aphids/5cm twig/plant) protected the crop from aphid infestation up to 40 days compared to untreated plots (41.1-42.3 aphids/5cm twig/plant). Treatments viz., seed treatment with imidacloprid + spray with dimethoate @1000 ml/ha; or seed treatment with thiamethoxam + spray with pymetrozine @ 300g/ha; or seed treatment with imidacloprid + spray with pymetrozine @ 300g/ha recorded significantly lower aphids and resulted in significantly higher seed yields.
A Generalization of Generalized Poisson-Lindley Distribution and its Applications
Authors: RamaShanker  , Kamlesh Kumar Shukla
Published: November 2023

In this paper we proposed a generalization of generalized Poisson-Lindley distribution which includes generalized Poisson-Lindley distribution, Poisson-Lindley distribution, Poisson- weighted Lindley distribution, negative binomialdistribution and geometric distribution as special cases. Statistical properties based on moments, maximum likelihood estimation and applications of the distribution have been discussed.