bluuebunny/crossref_metadata_2025 huggingface dataset:
Playing with Leadership: A Multiple Case Study of Leadership Development Larps
Authors: Hartyándi Mátyás , Van Bilsen Gijs
Published: June 2024

Learning and development solutions often contain some form of role-playing activity. Many live-action role-playing (larp) leisure events openly center their themes or story on leadership topics like conflicting visions, cooperation, or strategic decision-making. Despite this, only a few larps to date have dared label themselves as “leadership development” edu-larps.
This multiple-case study utilizes a synthesized theoretical framework that combines several typologies of both the leadership development research field and the fields of role-playing game studies, edu-larp, applied drama, and simulation. Four individual leadership development larps were identified, categorized by type, compared, and evaluated. The four cases have some striking similarities, as they all make use of the same learning cycle, have observers, and focus on developing versatility as a worthwhile leadership trait. Furthermore, all four larps have relatively few visible game mechanics, the hierarchical difference between characters is low and urgency or uncertainty is used to enhance learning.
The main difference between cases is the setting, where a modern business setting seems to be the default, but more fantastical settings, such as “samurai in feudal Japan” were also used. Character design also differs, from abstract roles to very-detailed personality descriptions. Framing, such as duration, varies from one 2-hour session through five sessions spread over weeks to a continuous 36-hour session. These and other identified differences and similarities highlight patterns to build upon by designers and gaps to fill with later research.
International Journal of Role-playing 15 -- Full Issue
Authors: Bowman Sarah Lynne , White William J. , Torner Evan , Hugaas Kjell Hedgard , Walsh Orla , Linehan Conor , Sottile Emry , Lehto Kerttu , Cullinan Maryanne , Hartyándi Mátyás , Van Bilsen Gijs , Riel Jeremy , Monahan Rob , Bartenstein Lennart
Published: June 2024

Sarah Lynne Bowman, William J. White, Evan Torner -- "Editorial: The Increasing Specificity and Maturity of Role-playing Game Studies"
Kjell Hedgard Hugaas -- “Bleed and Identity: A Conceptual Model of Bleed and How Bleed-out from Role-playing Games Can Affect a Player’s Sense of Self”
Orla Walsh and Conor Linehan -- “Roll for Insight: Understanding How the Experience of Playing Dungeons & Dragons Impacts the Mental Health of a Frequent Player”
Emry Sottile -- “‘It Might Have a Little to Do with Wish Fulfillment’: The Life-Giving Force of Queer Performance in TTRPG Spaces”
Kerttu Lehto -- “Nordic Larp as a Method in Mental Health Care and Substance Abuse Work: Case SÄRÖT”
Lennart Bartenstein -- “Live Action Role-playing (Larp) in Cognitive Behavioral Psychotherapy: A Case Study”
Maryanne Cullinan -- “Surveying the Perspectives of Middle and High School Educators Who Use Role-playing Games as Pedagogy”
Mátyás Hartyándi and Gijs van Bilsen -- “Playing With Leadership: A Multiple-Case Study of Leadership Development Larps” 
Jeremy Riel and Rob Monahan -- “Learning from Ludemes: An Inventory of Common Player Actions within Tabletop Role-Playing Games (TTRPGs) to Inform Principled Design of Game-Based Learning Experiences”
New Short-Circuited Coaxial Method Implementation for Complex Permittivity Measurement of Power Transformer Oils
Authors: Abualasal Ahmad , Kiss István
Published: June 2024

The investigation into the dielectric properties of transformer oils has been a focal point in both historical and contemporary electric insulation technology as high-voltage applications have greatly benefited from the continuous research efforts in this field. The dielectric permittivity is one of the factors to be negotiated when discussing the electric insulation of any material. This work aims to showcase a new short-circuited coaxial cable method to evaluate the complex dielectric permittivity of palm, sunflower and rapeseed oil and review other previously used measurement techniques. Mainly, the test was performed using a sample holder that represents a short-ended coaxial cable filled with the test material which is connected to one port of a vector network analyser. The measurements of the input impedance for various oil samples were conducted at frequencies ranging from 1 MHz to 10 MHz. The technique uses the value of the input impedance which depends on the reflected signals from the test sample to the network analyser, consequently, the value of the dielectric permittivity and dielectric loss have been calculated using the short circuit impedance formula which involves numerical methods to get the results which shows that this method can be used as an alternative to investigate the oils insulation parameters as it provides smooth results for permittivity without any divergence, ensuring more reliable and consistent measurements as well as providing high accuracy in determining the permittivity of materials.
Pelatihan Pengembangan Bahan Ajar Elektronik Menggunakan Software Flipping Book Bagi Guru SMKS Kota Bengkulu
Authors: Rina Elvia  , Ginting Sura Menda , Handayani Dewi
Published: June 2024

Kegiatan pengabdian ini bertujuan untuk meningkatkan kompetensi guru bidang IPA SMK swasta Kota Bengkulu melalui pelatihan pengembangan bahan ajar elektronik dengan menggunakan perangkat lunak flipping book. Flipping book merupakan software berbasis browser yang bisa digunakan untuk mengubah PDF menjadi suatu dokumen digital yang interaktif dimana software ini didukung dengan fitur content editor sehingga memungkinkan untuk menyisipkan video, gambar, dan audio kedalam bahan ajar yang dikembangkan Pengabdian pada masyarakat ini dilaksanakan di SMKS S 10 Kota Bengkulu. Khalayak sasaran dari kegiatan ini adalah para guru IPA perwakilan sekolah SMK Swasta di wilayah Kota Bengkulu. Kegiatan pelatihan ini mendapatkan sambutan yang baik dari para peserta pelatihan. Kegiatan ini diharapkan sangat bermanfaat untuk meningkatkan kompetensi guru dalam mengembangkan bahan ajar elektronik yang sesuai dengan perkembangan ilmu dan teknologi serta meningkatkan kualitas pembelajaran di sekolah.
PROGRAMA PARA LA MEJORA DE CALIDAD DE VIDA EN PACIENTES ONCOLÓGICAS DEL PROGRAMA CLUB DE LA MAMA ATENDIDAS EN EL INSTITUTO NACIONAL MATERNO
Authors: Manco-Avila Ermes , Moreno Valles Luisa , Huaranca-Berrocal Isabel , Chávez-Ochoa Paola , Porta Ericka , Umeres Jennifer , Oviedo Ronald , Silva Dominguez Daniel Sergio
Published: June 2024

ABSTRACT
Objective: To evaluate the results of a program for the improvement of the quality of life in oncological patients of the Club de la Mama attended at the INMP (2023) Materials and Methods: This research corresponds to a quasi-experimental study, which consists of the application of a program for the improvement of the quality of life in oncological patients attended during 2023, the total population was used, 8 participants, with ages between 41 and 71 years (mean=60. 25), to whom the entire program was applied (36 sessions, 9 months). The Quality of Life (QLQ-30), Anxiety (GAD-7), Depression (PHQ-9) and Stress (PSS-10) scales were applied at 4 moments, before starting the program, after 3 months (control 1), after 6 months (control 2) and finally after the total application of the program, 9 months (control 3). The analysis of frequencies and percentages of the variables, goodness of fit to the normal curve, and Student's t-tests for related samples (p>0.05) within groups with a confidence level of 95% were performed. Results: Significant differences were found between pretest and controls in their different variables, Quality of Life (p<0.05, increased from 35.29 to 66), Anxiety (p<0.05, decreased from 12.86 to 3.71), Depression (p<0.05, decreased from 12 to 2.14), and Stress (p<0.05, decreased from 28 to 15.14). Conclusion: The program implemented in the breast cancer club improved the quality of life of oncology patients at the end of their sessions.
Examining the Impact of Social Support Networks in Mitigating the Negative Effects of Social Determinants of Health on Msm in South Africa
Authors: Ikhile Ikekhwa Albert
Published: June 2024

This cross-sectional study explored the ways in which social support networks protect MSM individual in South Africa from the effects of Social determinant of health. Self-administered questionnaires and indept interview were used to establish the relationship between social support and social determinant of health status of 25 MSM in South Africa.The study established that MSM remains highly adaptable in social determinant of health challenges such that their mental health has greatly improved due to social diversities and structural support systems. Key informants identified peers, friends, family members, and local community based organizations as important in reducing the impact of stigma, discrimination and/or class differences. According to participants, such support networks ensured they received requisite healthcare services without encountering barriers. The study establishes that social support networks are vital in enhancing health equity and wellbeing among MSMs in South Africa. Therefore, the need to call for innovative strategies that increase support structures for MSM population in order to improve their health status cannot be overemphasized. Policy implications emphasize the need for interventions that reinforce supportive structures, promote inclusivity of MSM communities, and improve the health of this population in South Africa.
Pengembangan kemandirian digital melalui workshop digital marketing bagi generasi Z
Authors: Lazuarni Shafiera , Asharie Asmawati , Rahmawaty Putri
Published: June 2024

Kota Palembang mengalami perubahan besar dalam ranah teknologi informasi dan komunikasi. Namun masih banyak tantangan yang dihadapi generasi Z seperti kesenjangan keterampilan, kurangnya pemahaman tentang digital marketing, dan persaingan di pasar kerja. Hal ini menunjukkan perlunya pengembangan keterampilan digital marketing untuk mempersiapkan mereka masuk ke dalam pasar kerja yang semakin terdigitalisasi. Agar pelatihan berjalan efektif dan efisien, tim menggunakan metode ABCD. Audience: peserta diidentifikasi berdasarkan tingkat pengetahuan awal melalui survei. Behavior: peserta diharapkan memahami dan menerapkan channel digital marketing serta merencanakan kampanye digital yang efektif. Condition: materi disusun sesuai kebutuhan peserta, kegiatan dilaksanakan selama dua hari secara online menggunakan media presentasi, video tutorial, dan praktik langsung. Degree: Keberhasilan dievaluasi melalui penilaian sebelum dan sesudah pelatihan serta umpan balik untuk perbaikan kegiatan mendatang. Hasil kegiatan menunjukkan terjadi peningkatan pemahaman peserta dalam semua aspek yang dievaluasi. Pemahaman peserta meningkat menjadi baik atau sangat baik. Khususnya pada aspek channel marketing digital, perencanaan kampanye, analisis target audiens, strategi konten media sosial, struktur kampanye, dan penggunaan alat analisis digital meningkat dengan mayoritas peserta melaporkan pemahaman menjadi sangat baik di setiap aspek.
Pengelolaan keuangan keluarga dalam kehidupan sehari-hari: pendekatan praktis untuk petani dan peternak
Authors: Mau Ignatia Thomasita Bau , Wutun Maria Bernadethe Mawarni Gelu , Lejap Hedwigh Hendrikus Temai , Seran Adiutrix Maria Irayanti , Burin Stefanie Noviega Bribin , Watu Engelbertus Gloria Christy , Irianto Eugenius Dwi Ardhika , Amaral Maria Augustin Lopes
Published: June 2024

Pengabdian kepada masyarakat ini berfokus pada peningkatan kesejahteraan masyarakat Desa Bani-bani, Kecamatan Io Kufeu, Kabupaten Malaka, melalui edukasi dan pelatihan pengelolaan keuangan. Mayoritas penduduk desa ini bekerja sebagai petani dan peternak dengan penghasilan yang tidak tetap, dan saat ini hanya berfokus pada pemenuhan kebutuhan sehari-hari tanpa perencanaan untuk menabung atau investasi. Kondisi sosial yang menuntut pengeluaran tambahan untuk adat dan kegiatan sosial memperparah situasi finansial mereka.Kegiatan pengabdian ini mencakup edukasi finansial, pelatihan keterampilan kewirausahaan, akses terhadap layanan keuangan mikro, dan peningkatan literasi digital. Selain itu, program ini juga mengembangkan infrastruktur penunjang dan akses pasar untuk produk lokal. Implementasi asuransi pertanian dan perlindungan sosial juga diberikan untuk manajemen risiko. Melalui pendekatan ini, masyarakat diajak untuk aktif berpartisipasi dalam program-program yang dirancang, menciptakan komunitas yang kuat dan mendukung diversifikasi penghasilan. Diharapkan bahwa dengan adanya pelatihan dan bimbingan ini, masyarakat dapat mengelola keuangan mereka dengan lebih baik, menciptakan sumber penghasilan baru, dan meningkatkan kualitas hidup mereka secara berkelanjutan. Hasil dari kegiatan ini menunjukkan peningkatan kesadaran finansial dan kemampuan pengelolaan keuangan yang lebih baik di kalangan masyarakat Desa Bani-bani.
Numerical Simulation of the Effect of Air Velocity on Fin Heat Dissipation
Authors: Lui Haocheng
Published: June 2024

Fin has a good effect in strengthening heat dissipation, and the structure is simple, and it has been widely used in civil and industrial applications, such as radiators, automobile engine heat dissipation, air conditioning internal and external units, computer radiators and air preheaters of power station boilers. Based on the CFD numerical simulation method, the temperature change of the fin under different flow velocities is simulated. Result surface: When the calculation time is 100 seconds, when the air velocity is 0.5 m/s and 1 m/s, the heat dissipation of the fin is about 3.1℃ and 4.6℃ increasing than that at 0 m/s.
Energy Circuit of 1.3 MW with Brayton Cycle
Authors: Zhang Rongrong , Bazhanov A.
Published: June 2024

In this paper, a constructive scheme of the experimental device is proposed, and the principle of its operation is described in detail. The power circuit of the device has been drawn up. Complex impedance, frequency function, amplitude frequency characteristic and phase-frequency characteristic are obtained by mathematical transformation of the power circuit. The frequency response of the circuit is constructed. As a result of the calculations, we will obtain the amplitude frequency response and the phase frequency response. Using the found values of the characteristics, we will build graphs and draw conclusions about how the characteristics depend on the change in parameters and why the graph lines of the graphs are exactly the way they are.
On the Protection of Cultural Property in UNESCO’s Activities in the Context of Modern Armed Conflicts
Authors: Dzhumagulov A. , Baigazieva D. , Gabitova T.
Published: June 2024

Currently, UNESCO’s activities to protect cultural heritage acquire special meaning. The international legal aspects of UNESCO’s activities for the protection and protection of cultural heritage in the context of modern armed conflicts are examined. Examples of objects that are recognized as being in danger are given.
Features of the Subject and Method of Labor Law in Modern Conditions
Authors: Andashev U.
Published: June 2024

Explores the scientific-theoretical foundations of the subject and method of labor law in the conditions of a market economy, positions of leading scholars in the field of labor law, specifically the subject of labor law, issues of expanding its scope, and the mechanism for regulating labor relations during the transition period, that is, in market conditions.
The Role of the Departure of the Asset of Young Specialists in Reducing the Leakage of Teachers in the School
Authors: Khlebnikov A. , Fomina E.
Published: June 2024

The article describes the main aspects of the integration and retention of a young teacher in the profession, defines the conditions that ensure this process, and shows effective ways for educational organizations to accompany and support a young teacher. The features of a new generation of teachers who dictate modern realities are studied, due to which new risks of leaving a specialist's position arise, the name of one of them is burnout. The importance of proper integration into the work environment and preparation for the performance of work tasks is largely dictated by responsibility to the future generation. The personnel drain is accompanied by the migration of promising specialists to other countries, this is facilitated by the existing number of factors described in the article. The paper identifies current strategies to prevent professional burnout of young teachers – they will help not only increase the number of specialists in the profession, but also give them the opportunity to develop in a career environment, strive for success. Special attention is paid to gatherings of young professionals as one of the leading ways to prevent burnout in general. The article includes the specifics of spending time outside the work institution, describes the stages of participation in the meeting, as well as its mutually beneficial relationship with the school administration, which needs cooperation with projects of a city or country of this format. The professional success of a teacher largely depends not only on passing through the difficulties of a career path, but also on the ability to take an environmentally friendly approach to spending their internal resources, to find a source of replenishment. Gatherings of young specialists meet these demands and are able to broaden their horizons, social circle, and raise their awareness. Accommodating many positive influences on the teacher, the meetings have become an effective measure to prevent his professional burnout, building the prospect of his success.
From the Language of Chemistry to the Development of Education
Authors: Babayeva N. , Babayev Ya.
Published: June 2024

Since the written form of chemistry is richer and much more important than its oral form, the interaction of the language of the taught subject and education is explored using the example of chemistry. It was noted that special attention is paid to the study of the language of chemistry studied by students; teaching the subject “the role of the language of chemistry in the development of thinking” in the master’s program serves to facilitate the study of chemistry, which is a difficult area of ​​science. The content and role of the language of chemistry in teaching chemistry was clarified, and the language of chemistry was considered as a set of terminology, symbols and nomenclature. The language of chemistry is a chemistry teaching tool that has been shown to play an important role in students’ learning and development, being applied at all stages of chemistry learning. It was particularly noted that naming the branches separated from the main idea using chemical terminology and symbolism (word or appropriate image) as much as possible in the mind maps prepared by each participant during the teaching of various chemistry topics served to unify the respective mind maps with the language of chemistry and enriching the language of chemistry.
Using Mathematical Methods in Solving Chemical Problems
Authors: Arstanbekova N.
Published: June 2024

This article analyzes the definition of the concept of “problem” and discusses the main ways to solve chemical problems. The author proposes an algebraic method for solving chemical problems and an algorithm for solving a system of two equations with two variables by the substitution method.
Perspective of Islam's Participation in Nation Building of Kyrgyzstan
Authors: Osmonov S. , Kurbanova A.
Published: June 2024

The new format of relations between the state and religion should involve the involvement of the potential of Islam in the strengthening of national statehood and the development of civil society, taking into account the legal and moral norms of Islam. The format of relations between the state and religion should not include the separation of religion from the state, but the separation and non-interference of religious organizations from state institutions of power.
Lexical-Semantic and Stylistic Shadeness of Poetic Synonyms
Authors: Aliyev A.
Published: June 2024

Synonyms, as a rule, are distinguished by their unique qualities from other lexical units from the lexical-semantic point of view in the language. So, mainly two aspects attract more attention in this group of words. First, they are close in meaning. Some linguists even call them synonymous, depending on the meaning of the synonym word. On the other hand, synonymy is the diversity of words in terms of form. In addition to the common aspects of synonyms and their main features such as their capacity, processing in a wide aspect, gaining richness, creating comparison, elimination of repetition, nuances of meaning, emotional-expressiveness, each language also has its own characteristics. Based on this issue, the article discusses the general and different aspects of the lexical-semantic composition of synonyms in the artistic language, their poetic figurative functions, and explains each of them separately. In addition, synonymous rows their composition, the structure of these rows, the place of the dominant in the row and its distinguishing features, the function of phraseological units as synonym are explained in detail in the artistic language. Here, at the same time, the essence of synonyms is revealed in the artistic language as a concise, laconic description means, from the variety of images, events, conditions, etc. the emergence of the need to use new synonyms has been clarified. In this regard, the stylistic aspects of synonyms have been highlighted in artistic language. When having a broad conversation based on the stylistic nuances of synonyms in the artistic language, a number of issues that create a specific meaning variety of synonyms within the context, including their juxtaposition, the meaning capacity and breadth of any word in a synonymous line, the pairing of a number of words as synonyms, and the strengthening of meaning in a sentence, increasing harmony, appropriate expression of characters' moods, feelings and emotions, etc. more attention has been paid to such main aspects.
‘The ghost I expected to see’: Vernon Lee, the Gothic, and the Spectrality of Perception
Authors: Shane Anna
Published: June 2024

Vernon Lee considered the conventional ghost story to be in rather bad taste and, in her own Gothic fiction, evoked ghosts that are never directly apprehended, but are perceived as agential bodies nonetheless. The distinctive ghosts that Lee creates haunt by exploiting the mechanisms of perception that she studied and theorised throughout her career. I analyse Lee’s depictions of perception in three stories, ‘Oke of Okehurst’, ‘Amour Dure’, and ‘The Image’, through the lens of philosopher Alva Noë’s theory of perception as ‘a kind of skilful bodily activity’. Noë argues that we make sense of the world by using our sensorimotor knowledge – ‘a knowledge of the way sensory stimulation varies as a function of movement’. Lee’s ghosts draw on this sensorimotor knowledge of characters and readers, allowing her to convey a potentiality for agency without depicting unambiguously supernatural events. Using mirror neuron studies and cognitive readings of how works of art transport their audiences into virtual environments, I argue that this sensorimotor engagement builds up a cognisance of Lee’s haunting figures as agential bodies that occupy space, acted upon by the material world and, in turn, acting upon it. Lee used these ghosts to adopt speculative perspectives on perception and cognition more broadly, such as questioning the stability and reliability of perception, and suggesting a loss of identity involved in all acts of perception. These perspectives are excluded from her studies and essays but are explored in the fictional space that the Gothic opens up; in her gothic stories, Lee exploits the uncanny aspects of cognition, suggesting and experimenting with queerer and more speculative theories than the objective studies she also pursued could accommodate.
THE COGNITIVE COMPONENTS OF ANXIETY DURING SPEAKING TESTS AMONG OMANI LEARNERS
Authors: AL GHAITHI Ali , BEHFOROUZ Behnam
Published: June 2024

To find out the components and levels of cognitive anxiety among Omani learners, 110 participants were selected in three proficiency levels: elementary, pre-intermediate, and intermediate. To collect the data, a questionnaire adapted from Thomas et al. (2017) Cognitive Test Anxiety Scale (CTAS-2) was used and some statistical analysis was run to measure other variables including gender and English proficiency levels on the amount of cognitive anxiety that students experience during speaking examinations. The results of the study revealed that lack of confidence and sleep, fear of failure, and immediate feedback were the primary sources of anxiety at either average or high levels during the speaking examination sessions. In addition, the study could not find any effect of gender on anxiety. The elementary English proficiency level students suffer more during the speaking examination. The results suggest that teachers provide a comfortable examination environment by fostering some jokes and laughter. Punctuality of examiners, and giving one or two minutes extra to exceptional cases assist in stress reduction during speaking examinations. In addition, the findings suggest that institutions and curriculum developers prepare semi-authentic speaking examination situations to reduce the cognitive elements of test anxiety by designing game-based speaking tasks.
BETAWI MALAY DOCUMENTATION BASED ON COLOUR NAMING DIFFERENTIATION IN JAKARTA AND BEKASI DIALECTS
Authors: SYARFINA Tengku , SINAR T. Silvana , ROSA Rusdi Noor , BUDIONO Satwiko
Published: June 2024

The number of speakers of Betawi Malay is decreasing due to both external and internal factors. The rapid migration to Jakarta, the home of Betawi people, and the negative attitude of the Betawi Malay native speakers towards their language have endangered the existence of Betawi Malay language. The same case also happened to Betawi Malay spoken in Bekasi, the other area where Betawi people live. Tangible efforts to save Betawi Malay language are needed, one of which is through Betawi Malay documentation. In this study, the documentation focused on colour vocabulary. This study aimed to find how far the colour vocabulary of Betawi Malay spoken in Jakarta and in Bekasi is different. This study used a qualitative method. The native speakers of Betawi Malay living in Jakarta and Bekasi were taken as the informants. Observations, interviews, questionnaires, and documents were used to collect the data. A semantics approach was used in analysing the data. The results of the study show that the colour used in Betawi Malay spoken in Jakarta and Bekasi is differentiated by colour association, environment, and attitude. Environmental factors are very influential in building the speaker’s way of thinking and the speaker’s identity.
IMPLEMENTING MIXED AUGMENTED AND VIRTUAL REALITY IN AN ANIMATED FLIPPED CLASSROOM FOR LOW-ACHIEVING WRITERS IN RURAL PRIMARY SCHOOLS
Authors: JALALUDDIN Ilyana , DARMI Ramiza , ISMAIL Lilliati
Published: June 2024

The study examined the implementation of mixed augmented and virtual reality in an animated flipped classroom for low-achieving writers in rural primary schools. A quasi-experimental study employing a pre-post, non-equivalent control group design was conducted. In a flipped classroom, students use digitised or online lectures as pre-class homework, then engage in active learning process in the classroom such as peer teaching, projects, problem solving and group activities. In other words, the typical classroom of lecturing only during class time is “flipped” now to active activities that involve problem solving and group project work in class. Results show that this flipped learning approach improves rural learners’ proficiency, particularly in vocabulary acquisition. It was found that there was a statistically significant difference in vocabulary level between trials at the midway time point. Apart from that, there is a statistically significant difference in the vocabulary level in the intervention trial at the end (post) of the trials. However, successful implementation of this technology necessitates a comprehensive approach considering cultural and infrastructural factors.
Pembelajaran Pecahan Melalui Pendekatan PMRI Berbantuan Media Bambu
Authors: Khabibatur Rohmah Dwi Putri , Vika Ivania  , Eka Zuliana
Published: June 2024

Penelitian ini bertujuan untuk mengetahui penggunaan materi pecahan dengan menggunakan pendekatan PMRI berbantuan media bambu. Sumber data pada penelitian ini adalah peserta didik kelas 4 SD 3 Jepang. Metode yang digunakan adalah metode penelitian deskriptif kualitatif dengan metode deskriptif. Dalam pembelajaran matematika materi pecahan dengan pendekatan PMRI menggunakan media bambu adalah membahas mengenai konsep pecahan, menentukan nilai pecahan, dan membandingkan nilai pecahan. Hasil penelitian menunjukkan bahwa setelah penerapan model pembelajaran PMRI siswa dapat merasakan ketertarikan, dan dapat memperluas pengetahuan matematikanya, dan juga meningkatkan aktivitas siswa. Misalnya saja pada saat proses pembelajaran, siswa berani berinteraksi satu sama lain dan antara siswa dengan guru.
Pengaruh Model Pembelajaran Pendidikan Matematika Realistik Indonesia (PMRI) Terhadap Kemampuan Numerasi Siswa
Authors: Wijayanti Amelia Anggun , Marhaeni Nafida Hetty
Published: June 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh model pembelajaran Pendidikan Matematika Realistik Indonesia (PMRI). Subjek penelitian ini adalah siswa kelas 10 pada salah satu SMA Negeri di Yogyakarta. Jenis penelitian ini menggunakan penelitian eksperimen dengan desain eksperimen semu atau quasi eksperimental. Teknik pengumpulan data menggunakan penyebaran soal pretest dan posttest. Instrumen penelitian yang digunakan adalah lembar tes. Analisis data yang digunakan adalah uji normalitas, uji homogenitas, dan uji paired sample t-test. Hasil penelitian menunjukkan bahwa ada perbedaan nilai rata-rata antara pretest dan postest yang menunjukkan bahwa terdapat peningkatan rata-rata yang signifikan sebesar 33,30. Hasil hipotesis menunjukkan perbandingan uji thitung dan ttabel, dimana diperoleh nilai thitung sebesar 26,281 dan nilai ttabel sebesar 2,030. Artinya nilai thitung > ttabel. Artinya model pembelajaran Pendidikan Matematika Realistik Indonesia (PMRI) mempengaruhi kemampuan numerasi Siswa.
Pengaruh Model Pembelajaran Mind Mapping Berbantuan Powerpoint Terhadap Hasil Belajar Pada Materi Lingkaran Kelas VIII
Authors: Wahida Shofia , Nanang Nabhar Fakhri Auliya
Published: June 2024

Penelitian ini bertujuan untuk membuktikan ada atau tidaknya Pengaruh Model Pembelajaran Kooperatif Tipe Mind Mapping Berbantu Powerpoint Terhadap Hasil Belajar Matematika Siswa Kelas VIII Pada Materi Konsep Lingkaran. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksperimen. Sedangkan desain yang diterapkan yaitu  true experimental design dengan bentuk  possttest only control design. Metode pengumpulan data pada penelitian ini menggunakan tes soal pilihan ganda sebanyak 10 butir soal. Pengumpulan data yang diperoleh, hasil perhitungan didapat nilai rata-rata kelas eksperimen 69, sedangkan nilai rata-rata kelas kontrol 51. Berdasarkan hasil uji hipotesis menggunakan bantuan SPSS, didapat hasil nilai  = 1,670. Maka, ditolak atau diterima. Penelitian ini menghasilkan bahwa hasil belajar matematika siswa yang dikenai model pembelajaran mind mapping pada kelas eksperimen lebih baik dari pada hasil belajar matematika siswa pada kelas kontrol yang dikenai model pembelajaran langsung.
Five novel cis-regulatory deletions of SOX10 cause Waardenburg syndrome type II
Authors: Huang Yu , Geng Jia , Long Yang , Xiong Wenyu , Kang Lu , Chen Meilin , Tang Ting , Zhong Mingjun , Bu Fengxiao , Lu Yu , Cheng Jing , Yuan Huijun
Published: June 2024

Introduction

Waardenburg syndrome (WS) is a genetic disorder characterized by hearing loss, hypopigmentation, and distinct facial features. Despite > 60% molecular diagnosis rate for WS patients, pathogenic variants within coding regions are predominant, with few non-coding copy number variations (CNVs) reported.

Methods

In this study, we performed whole genome sequencing (WGS) on 59 undiagnosed WS patients and analyzed the CNVs within the promoter and enhancer regions of the SOX10 gene.

Results

We identified five novel pathogenic deletions ranging from 448 bp to 70 kb upstream of SOX10. Two deletions were in the enhancer region, while three were in the promoter and 5'UTR region. These CNVs manifested as WS type II in eight patients from five unrelated families, demonstrating phenotypic heterogeneity. Furthermore, analysis of CNV1 within the enhancer region suggested a potential mechanism involving Alu-mediated non-allelic homologous recombination (NAHR).

Conclusion

Our findings extend the mutation spectrum of the SOX10 gene and elucidate the pathogenic role of CNVs in cis-regulatory elements, particularly variations in enhancer and promoter regions, thereby enhancing clinical gene detection and interpretation of non-coding regions.
Parametrical design and optimization of a reverse circulation drill bit for dust control
Authors: Fan Liming , Li Zhilin , Luo Yongjiang
Published: June 2024

The reverse circulation down-the-hole air hammer drilling (RC-DTH) method is renowned for its efficiency in hard rock formations and exceptional dust control performance. It presents opportunities for cost-saving, efficiency improvement, energy conservation, and environmental protection. Reverse circulation drill bits are critical components of this method. This study focused on the air reverse circulation regime, investigating various geometric parameters of the RC drill bits through computational and experimental methods to enhance its dust control performance. Results indicate that increasing the layers of suction nozzles, enlarging the diameters of the suction and mixing nozzles, and optimizing the input airflow rate can effectively channel airflow toward the central passage of the drill tool. Consequently, this optimization significantly improves the dust control performance of the RC drill bits. Conversely, increases in the flushing nozzle diameter and alterations in the suction nozzle location have detrimental effects on the dust control capability of the RC drill bits. Field tests were conducted at the Yuan Jiacun iron mine, affiliated with Taiyuan Iron and Steel (Group) CO., LTD. The field tests demonstrate that the optimized RC drill bit exhibits excellent dust performance.
In silico discovery of potential PPI inhibitors for anti-lung cancer activity by targeting the CCND1-CDK4 complex via the P21 inhibition mechanism
Authors: Tang Weijian , Shen Tao , Chen Zhoumiao
Published: June 2024

Non-Small Cell Lung Cancer (NSCLC) is a prevalent and deadly form of lung cancer worldwide with a low 5-year survival rate. Current treatments have limitations, particularly for advanced-stage patients. P21, a protein that inhibits the CCND1-CDK4 complex, plays a crucial role in cell proliferation. Computer-Aided Drug Design (CADD) based on pharmacophores can screen and design PPI inhibitors targeting the CCND1-CDK4 complex. By analyzing known inhibitors, key pharmacophores are identified, and computational methods are used to screen potential PPI inhibitors. Molecular docking, pharmacophore matching, and structure-activity relationship studies optimize the inhibitors. This approach accelerates the discovery of CCND1-CDK4 PPI inhibitors for NSCLC treatment. Molecular dynamics simulations of CCND1-CDK4-P21 and CCND1-CDK4 complexes showed stable behavior, comprehensive sampling, and P21’s impact on complex stability and hydrogen bond formation. A pharmacophore model facilitated virtual screening, identifying compounds with favorable binding affinities. Further simulations confirmed the stability and interactions of selected compounds, including 513457. This study demonstrates the potential of CADD in optimizing PPI inhibitors targeting the CCND1-CDK4 complex for NSCLC treatment. Extended simulations and experimental validations are necessary to assess their efficacy and safety.
Effect of near-infrared spectroscopy on postoperative delirium in cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis
Authors: Sun Qian , Wu Weiguo
Published: June 2024

Background

Postoperative delirium (POD) is a common anesthetic side effect in cardiac surgery. However, the role of oxygen saturation monitoring in reducing postoperative delirium has been controversial. Therefore, this meta-analysis aimed to analyze whether NIRS monitoring during cardiac surgery under cardiopulmonary bypass could reduce the incidence of postoperative delirium.

Methods

PubMed, Web of Science, Cochrane Library, Embase and China National Knowledge Infrastructure (CNKI) databases were systematically searched using the related keywords for randomized-controlled trials (RCTs) published from their inception to March 16, 2024. This review was conducted by the Preferred Reporting Project and Meta-Analysis Statement (PRISMA) guidelines for systematic review. The primary outcome was postoperative delirium, and the second outcomes included the length of ICU stay, the incidence of kidney-related adverse outcomes, and the incidence of cardiac-related adverse outcomes.

Results

The incidence of postoperative delirium could be reduced under the guidance of near-infrared spectroscopy monitoring (OR, 0.657; 95% CI, 0.447–0.965; P = 0.032; I2 = 0%). However, there were no significant differences in the length of ICU stay (SMD, 0.005 days; 95% CI, −0.135–0.146; P = 0.940; I2 = 39.3%), the incidence of kidney-related adverse outcomes (OR, 0.761; 95% CI, 0.386–1.500; P = 0.430; I2 = 0%), and the incidence of the cardiac-related adverse outcomes (OR, 1.165; 95% CI, 0.556–2.442; P = 0.686; I2 = 0%) between the two groups.

Conclusion

Near-infrared spectroscopy monitoring in cardiac surgery with cardiopulmonary bypass helps reduce postoperative delirium in patients.

Systematic Review Registration

PROSPERO, identifier, CRD42023482675
A study protocol for a non-randomised evaluation of a growth-based career construction psychosocial intervention for higher education students
Authors: Chim Kathleen , Lai JoJo T. C.
Published: June 2024

Background

Despite promising emerging evidence on the protective properties and interrelationships of posttraumatic growth, career adaptability and psychological flexibility, no studies have reported interventions that promote these positive personal resources among higher education students. Nurturing these positive personal resources in future interventions is recommended to holistically address students’ developmental, academic and career-related challenges associated with major transitions. This paper describes (a) the rationale for and development of a tailored growth-based career construction psychosocial intervention, ‘Sailing through Life and My Career Path’ (SLCP) for higher education students; and (b) a mixed-method non-randomised pre-post study to evaluate the effectiveness of the proposed psychosocial intervention in achieving positive participant outcomes.

Methods and analysis

Over a 12-week period, higher education students will be recruited to take part in group and independent learning activities that are tailored to nurture positive personal resources to overcome challenges related to developmental, academic and career-related transitions. Quantitative data will be collected before and after the intervention and will be analysed using SPSS v26. Follow-up semi-structured interviews with participants (students), interventionists (group facilitators), and administrators will be conducted to explore perceptions of the intervention, to understand its process of change, and to determine its feasibility and acceptability in the higher education setting. All interviews will be transcribed and analysed using thematic analysis.

Discussion

By filling in a gap in existing intervention research and practice, the proposed study serves to generate new knowledge and insights by evaluating the effectiveness of a tailored psychosocial intervention that responds to the complex needs associated with major life transitions of higher education students.
The role of diet in diabetes gastroparesis treatment: a systematic review and meta-analysis
Authors: Lin Dezhi , Wang Hui , Ou Yangxu , Li Longlong , Zhang Qiang , Yan Jiayin , Peng Dezhong , Peng Sihan
Published: June 2024

Background

Diabetic gastroparesis is a common complication in patient with diabetes. Dietary intervention has been widely used in the treatment of diabetic gastroparesis. The aim of this study is to evaluate the role of diet in the treatment of diabetic gastroparesis.

Methods

This systematic review was conducted a comprehensive search of randomized controlled trials using dietary interventions for the treatment of diabetic gastroparesis up to 9 November 2023. The primary outcomes were gastric emptying time and clinical effect, while fasting blood glucose, 2-hour postprandial blood glucose and glycosylated hemoglobin were secondary outcomes. Data analysis was performed using RevMan 5.4 software, and publication bias test was performed using Stata 15.1 software.

Results

A total of 15 randomized controlled trials involving 1106 participants were included in this review. The results showed that patients with diabetic gastroparesis benefit from dietary interventions (whether personalized dietary care alone or personalized dietary care+routine dietary care). Compared with routine dietary care, personalized dietary care and personalized dietary care+routine dietary care can shorten the gastric emptying time, improve clinical efficacy, and reduce the level of fasting blood glucose, 2-hour postprandial blood glucose and glycosylated hemoglobin.

Conclusions

Limited evidence suggests that dietary intervention can promote gastric emptying and stabilize blood glucose control in patients with diabetic gastroparesis. Dietary intervention has unique potential in the treatment of diabetic gastroparesis, and more high-quality randomized controlled trials are needed to further validate our research results.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42023481621.
Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor
Authors: Brown Conner , Kariuki Wangeci , Zhong Haizhen A. , Kippes Audra , Sui Yipeng
Published: June 2024

Background

Cannabidiol (CBD), a non-psychoactive phytocannabinoid of cannabis, is therapeutically used as an analgesic, anti-convulsant, anti-inflammatory, and anti-psychotic drug. There is a growing concern about the adverse side effects posed by CBD usage. Pregnane X receptor (PXR) is a nuclear receptor activated by a variety of dietary steroids, pharmaceutical agents, and environmental chemicals. In addition to the role in xenobiotic metabolism, the atherogenic and dyslipidemic effects of PXR have been revealed in animal models. CBD has a low affinity for cannabinoid receptors, thus it is important to elucidate the molecular mechanisms by which CBD activates cellular signaling and to assess the possible adverse impacts of CBD on pro-atherosclerotic events in cardiovascular system, such as dyslipidemia.

Objective

Our study aims to explore the cellular and molecular mechanisms by which exposure to CBD activates human PXR and increases the risk of dyslipidemia.

Methods

Both human hepatic and intestinal cells were used to test if CBD was a PXR agonist via cell-based transfection assay. The key residues within PXR’s ligand-binding pocket that CBD interacted with were investigated using computational docking study together with site-directed mutagenesis assay. The C57BL/6 wildtype mice were orally fed CBD in the presence of PXR antagonist resveratrol (RES) to determine how CBD exposure could change the plasma lipid profiles in a PXR-dependent manner. Human intestinal cells were treated with CBD and/or RES to estimate the functions of CBD in cholesterol uptake.

Results

CBD was a selective agonist of PXR with higher activities on human PXR than rodents PXRs and promoted the dissociation of human PXR from nuclear co-repressors. The key amino acid residues Met246, Ser247, Phe251, Phe288, Trp299, and Tyr306 within PXR’s ligand binding pocket were identified to be necessary for the agonistic effects of CBD. Exposure to CBD increased the circulating total cholesterol levels in mice which was partially caused by the induced expression levels of the key intestinal PXR-regulated lipogenic genes. Mechanistically, CBD induced the gene expression of key intestinal cholesterol transporters, which led to the increased cholesterol uptake by intestinal cells.

Conclusion

CBD was identified as a selective PXR agonist. Exposure to CBD activated PXR signaling and increased the atherogenic cholesterol levels in plasma, which partially resulted from the ascended cholesterol uptake by intestinal cells. Our study provides potential evidence for the future risk assessment of CBD on cardiovascular disease, such as dyslipidemia.
Identifying genomic variant associated with long QT syndrome type 2 in an ecuadorian mestizo individual: a case report
Authors: Tamayo-Trujillo Rafael , Ibarra-Castillo Rita , Laso-Bayas José Luis , Guevara-Ramirez Patricia , Cadena-Ullauri Santiago , Paz-Cruz Elius , Ruiz-Pozo Viviana A. , Doménech Nieves , Ibarra-Rodríguez Adriana Alexandra , Zambrano Ana Karina
Published: June 2024

Introduction

Long QT syndrome (LQTS) is an autosomal dominant inherited cardiac condition characterized by a QT interval prolongation and risk of sudden death. There are 17 subtypes of this syndrome associated with genetic variants in 11 genes. The second most common is type 2, caused by a mutation in the KCNH2 gene, which is part of the potassium channel and influences the final repolarization of the ventricular action potential. This case report presents an Ecuadorian teen with congenital Long QT Syndrome type 2 (OMIM ID: 613688), from a family without cardiac diseases or sudden cardiac death backgrounds.

Case presentation

A 14-year-old girl with syncope, normal echocardiogram, and an irregular electrocardiogram was diagnosed with LQTS. Moreover, by performing Next-Generation Sequencing, a pathogenic variant in the KCNH2 gene p.(Ala614Val) (ClinVar ID: VCV000029777.14) associated with LQTS type 2, and two variants of uncertain significance in the AKAP9 p.(Arg1654GlyfsTer23) (rs779447911), and TTN p. (Arg34653Cys) (ClinVar ID: VCV001475968.4) genes were identified. Furthermore, ancestry analysis showed a mainly Native American proportion.

Conclusion

Based on the genomic results, the patient was identified to have a high-risk profile, and an implantable cardioverter defibrillator was selected as the best treatment option, highlighting the importance of including both the clinical and genomics aspects for an integral diagnosis.
Quantifying spatial CXCL9 distribution with image analysis predicts improved prognosis of triple-negative breast cancer
Authors: Cao Xi , Song Yu , Wu Huanwen , Ren Xinyu , Sun Qiang , Liang Zhiyong
Published: June 2024

Background: The C-X-C motif chemokine ligand 9 (CXCL9) plays a pivotal role in tumor immunity by recruiting and activating immune cells. However, the relationship between CXCL9 expression and prognosis in triple-negative breast cancer (TNBC) is unclear.

Methods: We investigated CXCL9 mRNA expression, clinicopathological features, and prognosis in TNBC patients. We also used computational image analysis to quantify and assess the distribution of CXCL9 protein in the tumor core (TC) and invasive margin (IM).

Results: CXCL9 mRNA expression was significantly higher in TNBC tumors compared to normal tissue (p < 0.001) and was associated with smaller tumors (p = 0.022) and earlier stages (p = 0.033). High CXCL9 mRNA expression was correlated with improved overall survival (OS) in three independent cohorts (all p < 0.05). In a separate analysis, low CXCL9 protein expression was associated with increased lymph node metastasis (p = 0.018 and p = 0.036). High CXCL9 protein expression in the TC, IM, or both was associated with prolonged OS (all p < 0.001).

Conclusion: High CXCL9 expression, at both the mRNA and protein levels, is associated with improved prognosis in TNBC patients. CXCL9 expression in the TC and/or IM may be an independent prognostic factor.