bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-World Clinical Outcomes of a Virtual Integrated Diabetes Program for Patients with Type 1 and Type 2 Diabetes (Preprint)
Authors: Wu Calvin , Wu Karin , Reddy Sushma
Published: June 2023

BACKGROUND

Telemedicine and messaging with a diabetes care team can overcome geographic barriers to specialized care for diabetes patients living in under-resourced areas, and enable more frequent clinical interactions, which have been shown to reduce the time needed to achieve HbA1c <7.0%. Carbon Health created a novel multidisciplinary diabetes care model that harnesses the strengths of these interventions and delivers care that is as data-driven and personalized as it is collaborative and person-centered.

OBJECTIVE

To examine the clinical efficacy of a virtual diabetes care model integrating remote continuous glucose monitoring and multi-disciplinary care.

METHODS

We performed a retrospective chart review of patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) in Carbon Health’s diabetes program with a baseline HbA1c on file. Primary outcome measures include change in HbA1c and long-term time in range (%LTIR), long-term time below range (%LTBR), and Glucose Management Indicator (GMI), calculated from aggregated CGM data since the first week time in range >70% was achieved. Exploratory measures included change in weight and change in Problem Areas in Diabetes (PAID) survey scores. Patients were asked to complete a questionnaire assessing their satisfaction.

RESULTS

A total of 230 patients (36.1% with T1D; 45.6% taking insulin; median baseline HbA1c 8.0%) were included. Over a median follow-up of 38 weeks, patients across all baseline HbA1c categories saw HbA1c reductions, up to -4.3% in patients with baseline HbA1c ≥9.0%. Patients with baseline HbA1c ≥7.0% maintained a median (IQR) GMI 6.8% (6.4 to 7.3%), %LTIR 82.3% (66.3 to 94.9%), and %LTBR 0.4% (0.1 to 1.3%) on long-term data. Improvements in PAID score and weight in patients with overweight/obesity were seen. Of 51 survey respondents, all expressed satisfaction with the program.

CONCLUSIONS

These findings suggest our virtual integrated diabetes program helps patients with T1D and T2D achieve and maintain clinical glycemic targets. Benefits were accompanied by improvements in diabetes self-management, diabetes-related distress, and weight in overweight individuals.

CLINICALTRIAL

Not applicable
Thành phần hóa học, khả năng kháng khuẩn và kháng oxi hóa của Xuyên tâm liên Andrographis paniculata (Burm.f.) nees phân bố ở Cần Thơ, Sóc Trăng và An Giang
Authors: Nguyễn Thị Ngọc Huệ , Võ Thị Hạnh , Huỳnh Thị Ngọc Hà , Đinh Công Khải , Nguyễn Thị Đẹp , Phan Thành Đạt , Phùng Thị Hằng , Nguyễn Trọng Hồng Phúc
Published: June 2023

Xuyên tâm liên (Andrographis paniculata) là loài thực vật được sử dụng để điều trị, ngăn ngừa các bệnh truyền nhiễm. Nghiên cứu này khảo sát thành phần hóa học và hoạt tính sinh học của xuyên tâm liên được phân bố ở Cần Thơ, Sóc Trăng và An Giang thông qua phương pháp phản ứng so màu, phương pháp trung hòa gốc tự do DPPH (2,2-Diphenyl-1-picrylhydrazyl) và phương pháp khuếch tán giếng thạch. Kết quả khảo sát ghi nhận có 10 nhóm hợp chất có trong dịch chiết của A. paniculata gồm carbohydrate, glycoside tim, flavonoid, phenol, amino acid và protein, saponin, tanin, coumarin, diterpene, nhựa. Cao chiết nước ở Cần Thơ và methanol ở An Giang có hiệu quả trung hòa gốc tự do DPPH tốt nhất. Hầu hết các cao chiết xuyên tâm liên kháng được các dòng vi khuẩn gồm Bacillus cereus, Bacillus subtilis, Escherichia coli, Listeria innocua và Salmonella. Kết quả nghiên cứu cho thấy cây xuyên tâm liên chứa nhiều hợp chất có hoạt tính sinh học, có khả năng kháng khuẩn và kháng oxi hóa tốt, có giá trị cao khi dùng làm thuốc, góp phần bảo vệ và chăm sóc sức khỏe cộng đồng.
Đặc tính đất, cấu trúc giải phẫu thực vật và sự hiện diện vi khuẩn trong đất vùng rễ, vi khuẩn nội sinh của cây Xuyên tâm liên Andrographis paniculata (Burm. f.) Nees
Authors: Phùng Thị Hằng , Tạ Hồng Thắm , Nguyễn Thị Yến Linh , Lê Ngọc Trâm , Nguyễn Thị Huyền Trân , Đỗ Thành Luân , Nguyễn Quốc Khương , Nguyễn Khởi Nghĩa , Nguyễn Trọng Hồng Phúc
Published: June 2023

Xuyên tâm liên (Andrographis paniculata) là cây có nhiều công dụng và là nguồn dược liệu tốt. Mối tương tác giữa hệ vi sinh vật và A. paniculata ở các mức độ khác nhau đã được khảo sát. Ba địa điểm nghiên cứu được chọn để phân tích đất, phân lập vi khuẩn, thu mẫu cây để xác định cấu trúc mô và vị trí cư trú của vi sinh vật. Kết quả cho thấy A. paniculata có khả năng thích nghi với nhiều loại đất. Năm mươi lăm dòng vi khuẩn đã được tìm thấy, trong đó số lượng vi khuẩn phân lập đất vùng rễ là cao nhất 18 dòng. Tại địa điểm đất có hàm lượng chất hữu cơ cao nhất (12,8 %) phân lập được nhiều vi khuẩn nhất (8 dòng) ngược lại tại nơi có hàm lượng chất hữu cơ thấp nhất (1,41 %) số lượng vi sinh vật phân lập được ít nhất (4 dòng). Các bộ phận trong cây đều phân lập được các vi sinh vật với số lượng khác nhau. Các mô với tế bào có vách bằng cellulose, nhiều chất dự trữ đều có vi sinh vật cộng sinh.
Xác định các điều kiện lên men, các hợp chất sinh học và hoạt tính kháng oxy hóa của rượu trái cây lên men từ quả cà na (Canarium album)
Authors: Huỳnh Ngọc Thanh Tâm , Nguyễn Thị Niềm , Lâm Thảo Nhi
Published: June 2023

Nghiên cứu được thực hiện với mục tiêu xác định các điều kiện ảnh hưởng đến quá trình lên men rượu vang cà na (Canarium album) sử dụng dòng nấm men Saccharomyces cerevisiae. Kết quả cho thấy sản phẩm rượu vang thu được có độ cồn cao (9,04% v/v) với mật số nấm men 107 tế bào/mL, dịch lên men được bổ sung đường saccharose đạt 25°Brix, pH 4,0 và lên men trong thời gian 12 ngày. Dịch quả và rượu vang cà na có sự hiện diện của các nhóm hợp chất sinh học như phenol, tannin, flavonoid, alkaloid, coumarin, quinone, saponin, terpenoid và steroid. Hàm lượng polyphenol tổng của dịch quả cà na cao hơn rượu vang cà na, cụ thể là 60,098 mg GAE/mL và 29,001 mg GAE/mL. Sau quá trình lên men, khả năng khử gốc tự do DPPH của rượu vang cà na đạt giá trị IC50 là 1,17 μL/mL, tăng so với dịch cà na ban đầu với giá trị IC50 là 4,97 μL/mL. Khả năng khử gốc peroxide H2O2 của rượu vang cà na có sự thay đổi không đáng kể sau quá trình lên men. Giá trị IC50 của rượu vang và dịch cà na lần lượt là 6,24 μL/mL và 4,47 μL/mL. Kết quả cho thấy dịch quả ban đầu và rượu vang cà na đều có khả năng kháng oxy hóa tốt.
Human Nature in Self-Identity Construct: A Meta-ethnography Study
Authors: Fachrunisa Rahma Ayuningtyas , Riyono Bagus
Published: June 2023

The development of identity theories in psychology tends to be partial and incoherent, and are followed by various problems. This study uses meta-ethnography to deconstruct theories of self-identity in order to find common threads and relation between theories, including main theories on identity (Erikson’s; Marcia’s), and other related theories (Berzonsky’s, Grotevant’s, Waterman’s, McAdams’s), This study uses Hofstede's (2001) view on identity theories, and formulates a fundamental and comprehensive conceptualization of identity theory. This study formulates a model of the layers of identity which includes the identity of (1) human nature, (2) personal, and (3) social. This study also explains the dynamics of the self as ‘I’ and ‘Me’ in the formation of identity. This study discusses human nature in the discourse of identity and this provides further implications in the field of developmental psychology and educational psychology.
Entrepreneurial Culture as Threat to SMEs’ Entrepreneurial Orientation-Success Relationship in Developing Countries – The Case of Private Healthcare Sector in Macedonia
Authors: Gjorevska Elena
Published: June 2023

Businesses face multiple challenges throughout their early years of performance. Entrepreneurial culture plays a significant role in the environmental ecosystem of the businesses in developing countries. Internally, having entrepreneurial orientation strategy at their business focus certainly improves SMEs’ position by initiating courage for exploring new opportunities and taking risk, initiate innovation, act proactively on the market and to set autonomy and competitive aggressiveness as standards in their operations. The study has proposed six theoretical propositions for entrepreneurial orientation-SMEs’ success relationship under the influence of the entrepreneurial culture. The six propositions derived from this context have been elaborated by applying a multiple-case research strategy. Participant companies have been part of the private healthcare sector in Macedonia. Interviews with the founders have been conducted to examine their personal views on the entrepreneurial culture in the country, as well as to practically test the propositions on their real business experience and current performance. Study results have indicated relatively low threat from the entrepreneurial culture to the entrepreneurial orientation dimensions and the businesses success correspondingly. Overall, the study has provided vital context-specific results that might guide managers in building strategies and plans that better suit local conditions and avoid adverse consequences.
La popularidad de las marcas y su valor económico en el marco de las finanzas corporativas: un análisis de aprendizaje máquina
Authors: Morales González Víctor Miguel , Dávila Aragón Griselda , Ortiz Arango Francisco
Published: June 2023

A lo largo del tiempo, la marca ha tomado un papel significativo en el ámbito empresarial, la percepción de la imagen comercial y el valor agregado. Este estudio está enfocado en explorar los componentes del concepto del valor de marca a partir de un diagnóstico y técnicas de aprendizaje máquina, para desarrollar una serie de modelos asociados a las dimensiones del valor de marca percibido desde un concepto más actual de la popularidad. La metodología de aprendizaje máquina, prioriza la predicción frente a la inferencia. No impone una especificación ni una teoría, a diferencia de la estadística clásica, donde se requiere especificar un modelo; esto representa una forma dinámica alternativa para entender cómo uno de los recursos más importantes de las empresas en el mercado está presente, lo que sin duda repercute en la gestión financiera y de riesgos de la empresa. Los resultados obtenidos mediante tres técnicas diferentes de aprendizaje máquina, muestran que las once variables propuestas en el estudio influyen positivamente con diferente intensidad en la popularidad de la marca.
Apuntes sobre los orígenes de la política en Hannah Arendt
Authors: Quintero Martín Sergio
Published: June 2023

El interés de Hannah Arendt en el fenómeno de la política recorre de manera transversal tanto su pensamiento como su obra. En una entrada de su Diario filosófico 1950-1973 (2018), Arendt reflexiona sobre el hecho de que la filosofía política tiene su origen, para la tradición filosófica occidental, entre el ocaso de la pólis y la respuesta que Platón ofreció ante la corrupción de la política. En cambio, si queremos hablar del origen de la política misma debemos retroceder, conforme a la genealogía arendtiana, a un tiempo más ligado a la narración mitológica que a la narración histórica: la guerra de Troya. La relación que Arendt guarda con el pensamiento helénico es esencial para comprender el núcleo programático de su pensamiento y su obra, sobre todo en la manera en que combina esas ideas con otras tradiciones como el aristotelismo, el republicanismo y con sus herencias germana y hebrea. Por esa razón, presentamos, de la mano de Roberto Esposito, un recorrido por las ideas que conforman el origen de la política para la fenomenología arendtiana, conformando un triángulo entre Troya, Atenas y Roma. Además, mostraremos los límites que presenta esta interpretación al entrar en diálogo con otra autora fundamental para entender la filosofía política en el siglo XX, Simone Weil. Sin conocerse, ambas autoras parecen complementarse mutuamente. El objetivo es visibilizar la importancia que tiene el mundo romano en el pensamiento arendtiano.
Medio, contingencia y sentido en la naturaleza
Authors: Berque Augustin , Olvera Zaida
Published: June 2023

En el presente escrito se examina la relación entre azar, contingencia y necesidad en la evolución de las especies y su vínculo con la mesología (Umweltlehre) de Jakob von Uexküll (1864-1944), con la lógica del lema de Yamauchi Tokuryû (1890-1982) y con la “ciencia natural” (shizengaku, 自然学) de Imanishi Kinji (1902-1992). Secciones: “Introducción: de la escolástica en mesología”; “Semiosis, mito y realidad”, “Tetralema y actualización del ser”, “Evolución y contingencia” y “El bebé se ha puesto de pie, of course”.
Role of Passive Design Techniques for a Comfortable Indoor Environment: Comparison between Tradition & Modern Architecture in Hot Climate
Authors: Verma Ar. Ekta , Srivastava Prof. Satyam
Published: June 2023

Abstract: This research aims to investigate the role of passive design techniques in creating a comfortable indoor environment in hot climates. It specifically focuses on comparing traditional and modern architectural approaches and their effectiveness in providing thermal comfort, energy efficiency, and sustainability. The study will explore the design principles, strategies, and technologies employed in both traditional and modern architecture to mitigate the impact of hot climates on indoor comfort. By analyzing various case studies and evaluating their performance, this research will provide insights into the strengths and weaknesses of each architectural style and offer recommendations for designing sustainable and comfortable indoor spaces in hot climate regions.
Balinese Arak as Substitute of Imported Spirits and Liqueurs in The Process of Making Dadar Gulung Flambe
Authors: Massenga Lidjah Magdalena , Arcana I Nyoman , Wiratnaya I Nyoman
Published: June 2023

Flambe is a cooking procedure in which alcohol is added to a hot pan to create a burst of flames. Flambéing is often associated with the tableside presentation of certain liqueur-drenched dishes set aflame, such as Bananas Foster or Cherries Jubilee when the alcohol is ignited and results in a flare of blue-tinged flame. Various innovations in the processing of flambe dishes have developed in the hospitality industry. “Dadar Gulung” traditional cake is an elongated round wet cake snack served with grated coconut mixed with liquid Javanese sugar called “unti”. Arak is a traditional alcoholoc drink distilled from “tuak” (palm nectar), namely coconut sap water, lontar or enau sap water and rice water which contains between 35% to 50% alcohol. Making Dadar Gulung Flambe by using Arak Bali drink as a substitute for imported spirits and liqueurs such as French Brandy or Jamaican Rum is one alternative to reduce the cost of food so that the selling price of this dish can be more affordable and will increase the use of local Balinese products as products sold in hotels and restaurants. The purpose of this study was to determine the level of liking for Dadar Gulung Flambe dishes that use Balinese Arak as a substitute for imported spirits and liqueurs. Through the Hedonic Test by distributing hedonic test questionnaires to 15 panelists using four assessment indicators, such as Taste, Aroma, Color and Texture. The results of this study showed that the average level of preference of panelists for Dadar Gulung Flambe who used Balinese Arak drink as a substitute for imported spirits and liqueurs was 4.3 in the Very Like category.
STRENGTH AND DURABILITY OF CONCRETES WITH A SUPER ABSORBENT POLYMER ADDITIVE
Authors: Sharafutdinov Kamil , Saraykina Ksenia , Kashevarova Galina , Sanyagina Yana , Erofeev Vladimir , Vatin Nikolai
Published: June 2023

The article presents an analysis of the results of experimental studies of the effect of different types of a super absorbent polymer additive on the strength of different types of concrete. The study is aimed at the effectiveness of a new type of super absorbent additive in concrete structures. In the course of full-scale experiments, it was possible to identify the optimum dosage of SAP for fine-grained and heavy concretes. In addition, the results showed that the strength of concrete remains unchanged if the dosage of super absorbent polymer additive (SAP) is 0.5% of the weight of cement or less. The possibility of modern intelligent technologies (artificial neural networks) to predict the properties of concrete mixture and hardened concrete at given values of input parameters (SAP dosage and W/C), influence on concrete characteristics (slump of the cone, bending strength, compressive strength) has also been shown.
EXPERIMENTAL AND THEORETICAL STUDIES OF DYNAMIC CHARACTERISTICS OF WOODEN FRAME BUILDINGS
Authors: Dmitrieva Tatiana , Podshivalova Kristina
Published: June 2023

The research carried out in this paper is reduced to studying the design features of wooden frame structures and analyzing the nature and degree of influence of individual structural elements on the work of the frame as a whole based on a comparison of experimental and theoretical data. The results of the studies with the evaluation of natural oscillations are the basis for the correct modeling of structural systems when performing static and dynamic calculations.
CALCULATION MODEL OF A MULTI-STOREY REINFORCED CONCRETE FRAME WITH COMPLEXLY STRESSED BEAMS UNDER ACCIDENTAL IMPACT
Authors: Moskovtseva Violetta , Fedorov Sergey , Amelina Margarita
Published: June 2023

A computational model is presented for determining deformations in complexly stressed beams of a structurally non-linear reinforced concrete frame in a transcendental state caused by a special emergency action in the form of a sudden removal of one of the structural elements. The determination of the stress-strain state after the formation of spatial cracks in the reinforced concrete elements of the frame was carried out using the calculated spatial section. At the same time, dynamic additional loads in the design section of the reinforced concrete frame element from a special impact are determined on an energy basis using the “bending moment-curvature” and “torque-angle of rotation” diagrams. The considered calculation algorithm includes the determination of forces in compressed concrete, longitudinal and transverse reinforcement for primary and secondary design schemes and verification of special limit state criteria. The results of a numerical analysis of the effect of cracking, the ratio of torque and bending moment on the stress state in transverse and longitudinal reinforcement and on the dissipative properties of a frame structural system are presented
Estudos sobre a direção de fotografia no Brasil
Authors: Roure Malta de Sá Ana Carolina , Fonseca Besen André , Corrêa Bonfim Felipe , Riscali de Lima Moraes Maria Fernanda
Published: June 2023

Estudos sobre a direção de fotografia no Brasil, organizado na coletânea Cinematografia, Expressão e Pensamento - Volume III, reúne textos de profissionais dedicados à pesquisa e à prática da direção de fotografia, agregando pesquisadores de diversas regiões brasileiras. Esse volume expressa o desejo de aprofundar tal campo de estudos, por meio de diferentes vertentes teórico-analíticas, promovendo um importante recorte temático sobre a cinematografia brasileira. Além disso, a antologia busca dar continuidade às propostas anteriores, que pretendiam evidenciar os esforços investigativos e criativos referentes à cinematografia, a fim de colaborar para a consolidação dessa área como campo de estudo. O livro é indicado a estudantes, professores, pesquisadores, realizadores audiovisuais e a todos aqueles que compreendem a importância da direção de fotografia na construção narrativa audiovisual. A coletânea se propõe a adentrar o universo da cinematografia, mais uma vez, em busca de evidenciar essa arte da expressão de um pensamento que se inscreve por meio de câmeras, lentes, movimentos, texturas, luzes e sombras.
Incidentally Detected Extensive Disseminated Cysticercosis in A Case of Nasopharyngeal Carcinoma
Authors: Wajpeyi Dr. Ketki , Vagha Dr. Sunita
Published: June 2023

Taenia solium, a pork tapeworm, causes a parasitic infection called cysticercosis. It is a frequent source of seizures and neurological morbidity in developing countries. An uncommon presentation of cysticercosis is neurocysticercosis, and till now, less than fifty cases have been noted in the world's literature; most of the cases belong to India. In this study, we have reported an unusual patient of a nasopharyngeal carcinoma presenting with occasional epistaxis and progressively enlarging left submandibular swelling, who has later diagnosed to harbor coexistent disseminated cysticercosis involving multiple sites in the body, namely the brain, extraocular muscles, skeletal muscles, tongue, heart, pleura, peritoneum, aortic wall, seminal vesicles, and scrotal sac. Here we report a 60 years old male patient presenting with occasional nasal bleeding, a headache for 6 months, and swelling in the left submandibular region for 4 months. In the past, the patient had a history of seizure episodes. Nasal endoscopy revealed a mass in the roof of the nasal cavity. A biopsy confirmed the diagnosis of nasopharyngeal carcinoma.Further radiological investigations were made for staging when the patient was detected with extensive rice grain calcifications leading to an incidental diagnosis of disseminated cysticercosis. The first case we know of was detected on an FDG PET/CT (fluorodeoxyglucose-positron emission tomography/computed tomography) scan. The patient was managed with chemoradiotherapy for nasopharyngeal carcinoma and subsequently 400 milligrams of oral albendazole, twice daily, and 20 milligrams of prednisolone, twice daily for three weeks for disseminated cysticercosis. Prednisolone was eventually waned off and terminated. The patient's condition had significantly improved at the 3-month follow-up, and no seizure recurrence was observed. This case report aims to depict the disease's presentation, provide information on this globally prevailing pathogen, and shed some light on the infection's diagnostic workup and therapeutic interventions.
Characteristics of firm misconduct and effects on capital market reactions
Authors: Collien Leon , Friedrich Christian , Quick Reiner
Published: June 2023

This article replicates earlier literature on capital market reactions to firm misconduct with rarely used Continental European data, after the financial crisis, and combines characteristics that previous literature has analyzed separately. We hand-collect press articles on 96 illegal misconducts of German firms between 2010 and 2019 and use the content of those articles to determine the misconduct type, misconduct characteristics, and information characteristics. Short-term cumulative abnormal returns (CARs) proxy for market reactions. We hypothesize and find negative market reactions that are stronger when the misconduct harms connected (vs. third) parties and when it primarily benefits the firm (vs. the offending individual). For information characteristics, we only find support for the prediction that markets react more negatively to confirmed misconduct (vs. suspicions). Some results are sensitive to including both misconduct and information characteristics or excluding financial statement fraud. Earlier research rarely tests for such sensitivity. Our research shows that market reactions to illegal misconduct are robust overall, but robust common determinants of effect strength are difficult to establish. These insights are of relevance for researchers when using capital market reactions to study misconduct implications and when referencing earlier research in this area.
FPGA-Based Cosimulation of S-Box Constitution from Fractional Order Liu System
Authors: arserim muhammet , TÜRK Ömer
Published: June 2023

Substitution box(S-box) has an important duty in encryption. In recent
years plenty of S-box designs by chaotic systems have been studied. In
this paper a high speed S-box constitution from fractional order Liu
system on FPGA is proposed. The design was implemented by using Xilinx
System Generator(XSG) toolbox in MATLAB/Simulink software in single
precision floating point numbers format and a low cost Basys 3 FPGA
trainer card was used. In addition, numerical fractional order equations
was solved by using Grünwald-Letnikov(GL) method with 1024 elements
length. The S-box table was constructed about 0.137s. After all
performance analyzes as nonlinearity, strict avalanche criterion,
differential probability, bits independent criterion, and equiprobable
input/output XOR distribution, were performed. The performance analyzes
shown that the design was satisfactory.
Neuropathy; its profile and experimental nerve injury neuropathic pain models: A Review
Authors: Sharma Kreshana , Fatma Nishat , Ali Zeesan , Moshin Mohd , Chandra Phool , Verma Anurag , Goshain Omprakesh , Kumar Gajendra
Published: June 2023

Neuropathy is a terrible disorder that has a wide range of aetiologies.
Drug-Induced Neuropathy, which happens whenever a chemical agent damages
the peripheral nerve system, has been linked here to iatrogenic creation
of some drugs. It is potentially permanent and causes sensory
impairments and paresthesia that typically affects the hands, feet, and
stockings; motor participation is uncommon. It might appear suddenly or
over time, and the long-term outlook varies. The wide range of chronic
pain conditions experienced by people has been some of the main
obstacles to developing new, more effective medications for the
treatment of neuropathic pain. Animal models can be used to examine
various neuropathic pain aetiologies and symptoms. Several models
investigate the peripheral processes of neuropathic pain, whereas some
even investigate the central mechanisms. such as drug induce models like
vincristine, cisplatin, bortezomib, or thalidomide, etc., and surgical
models like sciatic nerve chronic constriction injury (CCI), sciatic
nerve ligation through spinal nerve ligation (SNL), sciatic nerve damage
caused by a laser, SNI (spared nerve injury), etc. The more popular
animal models relying on peripheral nerve ligatures are explained. In
contrast to chronic sciatic nerve contraction, which results in
behavioral symptoms of less reliable stressful neuropathies, (SNI)
spared nerve injury generates behavioral irregularities which are more
feasible over a longer period. This review summarizes the latest methods
models as well as clinical ideas concerning this mechanism. Every
strongest current information on neuropathy is discussed, along with
several popular laboratory models for causing neuropathy.
Used paper tissues for pathogen identification in acute respiratory infection
Authors: Rector Annabel , Bloemen Mandy , Ranst Marc Van , Wollants Elke
Published: June 2023

During the Belgian winter and spring season 2022-2023, we
investigated the potential of used paper tissue (UPT) as a non-invasive
sampling method for the diagnosis of acute respiratory infections.
Screening for respiratory pathogens was done using an in-house developed
respiratory panel for simultaneous detection of 22 respiratory viruses
and 7 non-viral pathogens. The method allowed the identification and
typing of respiratory pathogens in symptomatic individuals, as well as
in collective samples taken at a community level. Pathogens that were
identified in nasal swabs could also be detected in concurrent UPT from
the same patient. In all cases that tested positive on an
antigen-detection rapid diagnostic test, the corresponding virus could
be detected in UPT. The collection of UPT could be useful in
epidemiological surveillance of SARS-CoV-2 and other coronaviruses, as
well as other respiratory pathogens such as influenzavirus, respiratory
syncytial virus, entero/rhinoviruses including EV D68,
parainfluenzaviruses and Streptococcus pneumoniae. Multiple
respiratory pathogens could be detected in UPTs of collectivities,
confirming its applicability for community testing. This is especially
interesting for screening in nursing homes, centers for the disabled,
schools or other settings were taking nasal or nasopharyngeal samples is
cumbersome.
A system of trust? Robert Brandom and Hegel’s phenomenology of spirit
Authors: Ramas San
Published: June 2023

In this paper, we discuss Robert B. Brandom?s reading of G. W. F. Hegel, especially his later work, A Spirit of Trust: A Reading of Hegel?s Phenomenology, in order to tackle the question of ?trust? as the structure of recognition. First, we reconstruct Brandom?s reading of Hegel?s philosophy as a form of ?social recognitive pragmatics? with a ?historical recollective account of conceptual content?, by which he aims at a re-definition of practical normativity based upon trust. Then, we examine his notion of trust as the ground for a future, post-modern society. Finally, we point at some difficulties concerning Brandom?s notion of post-modern age and examine the concept of trust as key to the modern understanding of social bonds.
Which king, whose sovereignty? Notes on the nation-state in times of globalization
Authors: Navarro Ruiz
Published: June 2023

One of the most prominent issues in contemporary social philosophy is the democratic institutionalization of social change. In the following paper, we analyze how such an objective must not overlook the changes wrought by globalization. To this end, we first present some of the critical responses to globalization presented by contemporary thinkers (Federici, Tomba, Srnicek). Next, we tackle the notions of the ?diffuse regime of transnational power?, ?lex mercatoria? and ?governance?, and point out how these concepts are indispensable for a complete understanding of the present of capitalism in the areas of trade and
Phraseology “without meaning”: Politics of emptiness
Authors: Ostojic Aleksandar , Cuckovic Aleksandar
Published: June 2023

We have heard many times expressions such as: ?empty words?, ?empty talk?, ?hot air?, but is there really an empty ?phraseology?, one that does not mean anything, i.e., that does not have a clear referent (the idea it refers to)? Showing the possibilities of such phraseology without meaning, the paper examines its use in politics, focusing on bureaucratic language that shapes our political reality, and can be found in many constitutional documents of the EU, US, or even UN. Namely, we will try to show that between general and particular meaning, there is a huge gap, an emptiness, which is used by a certain type of speech, in order to absorb every other language and its performative powers. Our criticism will move in two directions: the first has the task of showing the meaning(less) character of political bureaucratic phraseology as such, and its passivizing or non-affirmative effects. The other one comes down to examining the ideological background of Eurocentrism, detecting the hegemonic character of the idea of Europe (and Western civilizations) embedded in its political language. Starting from Ernesto Laclau?s understanding of the ?empty signifier? and the necessary function it has in the foundation of the system (especially a hegemonic one), through the history of the discourse of the idea of Europe, we will show the possibility and use of ?emptiness? in meaning, especially when it comes to core values that are set for the foundation of one?s politics.
The contribution of the road transport network to supporting development: The case of the Wilaya of M'sila, Algeria
Authors: Bouzid Hamza , Bouder Abdelmadjid , Zerouali Bilel
Published: June 2023

The paper evaluates the development and the capacities of action of the road
network, in particular, its degree of density and accessibility in specific
years of 1998 and 2017, in the Wilaya of M'sila, (Algeria). This paper aims
to understand the extent of the contribution of this network to support the
development in this region. To identify the municipal socio-economic
profile, 41 indicators were used, 6 to determine the road density, and 5 to
measure the accessibility. After comparing the results in the previously
specified years, it was found that there was an improvement in the density,
which included 10 municipalities, accompanied by a clear and repeated
positive development in 7 of the 41 development indicators in these 10
municipalities, in terms of accessibility, an improvement was noted in 7
municipalities, attached to 8 notable and repeated indicators. The results
also showed that the spatial distribution of road networks does not present
a clear trend, it does not necessarily tend towards a geographical
dependence, where are the grand urban localities, or the lower rank
localities. In addition, the contribution of road networks to socio-economic
factors are sometimes absent, and when it is present, it varies according
to the location or characteristics of the road network
(density/accessibility). In the case of density, the support consisted of a
decrease in migration rates, and a significant increase in birth rates, in
addition to an improvement in economic indicators. However, in the case of
accessibility, its contribution is somewhat different, since what
distinguishes it is that it helps to attract facilities, to choose the best
location.
The conflict between nature preservation and tourism in nature monument “Suma Kosutnjak”
Authors: Blagajac Irena
Published: June 2023

The subject of study is the conflict between nature preservation and tourism
in SP ?Suma Kosutnjak? and our task is to recognize the source of the
conflict, defining its causation along with possible consequences. The
consequences are attributed to the excessive impact tourists have on
natural treasure of the protected area. This study additionally considers
the immense touristic potential, under a caveat to reduce the influence of
tourism on the environment as much as possible. The goal of this study is to
suggest which measures can be used to lessen the conflict and recognize
which locations have the highest potential for environmental protection and
tourism development. The study was made using analysis, synthesis,
comparative and AHP methods. The analysed criteria for nature preservation
and development of tourism are land use, distance from the roads and forest
trails. It was necessary to analyse distance from settlements for nature
preservation, and analyse the terrain slope for tourism development. The
listed criteria are marked from 1 to 5 based on their importance for
environmental protection and tourism. Research results were shown in tables,
graphs and cartograms (using GIS tool).
Attracting Female Directors in the United States: The Roles of Boards, Executives, and Other Stakeholders
Authors: Cunningham Lauren M. , Ereddia Laurie E.
Published: June 2023

Previous research related to board gender diversity typically focuses on international settings outside of the U.S. In this study, we examine the influence of boards, executives, and other stakeholders in appointing a female director candidate to a U.S. board, which is a voluntary regime dominated by male candidates. Following institutional theory, social identity theory, and resource dependence theory, we find that boards, executives, and institutional investors play persistent roles across various time periods, company sizes, and levels of CEO power. Workforce and customer stakeholders have become significant influencers only in more recent years and in smaller firms. Understanding factors that allow firms to successfully attract female board members in a voluntary regime should be of interest to board members and regulators worldwide. Our findings should also be of interest to accounting academics examining the role of board gender diversity in the oversight of audit, financial reporting, and tax policies.

Data Availability: All data are publicly available from the cited sources.

JEL Classifications: G34; M48.
Supplier-Base Concentration and Cost Structure
Authors: Chen Clara Xiaoling , Di Lulu , Jiang Wei , Li Wei
Published: June 2023

In the past three years, companies across the globe have witnessed significant supply chain disruptions due to the COVID-19 pandemic, which highlights the importance of managing supply risk. Supply risk has increased in the last three decades due to an increasing prevalence of concentrated supplier bases. We predict that firms with high supplier-base concentration will choose a more elastic cost structure in response to the increased supply risk. Using a unique dataset of 4,530 firm-year observations hand-collected from supplier information disclosed by Chinese-listed firms, we document a positive association between supplier-base concentration and cost elasticity. Furthermore, results from five cross-sectional tests are consistent with supply risk driving the association between supplier-base concentration and cost elasticity. Our study provides important practical implications to managers. To the extent that supplier-base concentration poses a supply risk, our study suggests that managers can respond by making the cost structure more flexible.

Data Availability: Data are available from the public sources cited in the text.

JEL Classifications: L23; M41.
The Interactive Effect of Cognitive Frame and Performance Measurement System Scope on Managers’ Choice of Sustainable Suppliers
Authors: Pencle Nadra
Published: June 2023

Managerial response to stakeholders’ demands for profitability and sustainability can have long-lasting effects on organizations, stakeholders, and society. In an era dominated by business-case thinking, managers’ cognitive processes are particularly important. Yet alternatives to business-case thinking are underexamined. Operationally, to help direct attention toward sustainable goals, organizations implement performance measurement systems (PMS) with varying scope differences in the composition of financial and nonfinancial measures. To date prior research is inconclusive regarding the effectiveness of such actions. This study responds by mobilizing paradoxical thinking, an alternative form of cognition posited to better support complex managerial decisions. Experimentally, I investigate how cognitive frames moderate the effect of a broad versus narrow PMS in sustainable decision making. The results reveal managers who approach sustainable decisions with a paradoxical cognitive frame and are evaluated using broad PMS select more sustainable suppliers. These findings are important given the social and environmental implications of sustainability judgments.
The Effect of Negative Expectancy Violations and Relational Familiarity on Client Managers’ Negotiation Positions
Authors: Dodgson Mary Kate , Agoglia Christopher P. , Bennett G. Bradley
Published: June 2023

During the interactive process of issue resolution, client managers may develop expectations about the auditor’s position. We examine the effect that negative expectancy violations have on managers’ pre-negotiation positions and how relational familiarity can moderate this effect. Through a series of experiments, we find that, when the partner’s proposed adjustment is within the client’s original expectations, managers offer greater concessions to a more familiar partner than to a less familiar partner. However, depending on relational familiarity, client managers react to expectancy violations very differently. Managers react more severely when a more familiar partner violates expectations, offering lower negotiation concessions than when no violation occurs. In contrast, managers tend to ignore violations committed by a less familiar partner, offering similar negotiation concessions whether or not a violation has occurred. Furthermore, we find support for a practical intervention to repair damage from expectancy violations committed by more familiar partners.
Influence of gestational diabetes on diabetes risk and glycemic control in a retrospective population-based cohort
Authors: J. McCarthy Katharine , H. Liu Shelley , Huynh Mary , Kennedy Joseph , Tai Chan Hiu , L. Mayer Victoria , Vieira Luciana , Tabaei Bahman , Howell Frances , Lee Alison , Van Wye Gretchen , A. Howell Elizabeth , Janevic Teresa
Published: June 2023

  

Background. Racial/ethnic specific estimates of the influence of gestational diabetes mellitus on type 2 diabetes remain underexplored in large population-based cohorts. We estimated racial/ethnic differences in the influence of gestational diabetes on diabetes risk and glycemic control in a multiethnic population-based cohort of postpartum women.

Methods. Hospital discharge and vital registry data for New York City (NYC) births between 2009 and 2011 were linked with NYC A1C Registry data between 2009-2017. Those with baseline diabetes (n=2,810) were excluded for a final cohort of 336,276 births. Gestational diabetes on time to diabetes onset (two A1c tests of ≥ 6.5% from 12 weeks postpartum onward) or glucose control (first test of A1c<7.0% following diagnosis) was assessed using Cox regression with a time varying exposure. Models were adjusted for sociodemographic and clinical factors and stratified by race/ethnicity.     

Results. The cumulative incidence for diabetes was 11.8% and 0.6% among those with and without gestational diabetes. Gestational diabetes status on diabetes risk was aHR 11.5 (95% CI:10.8, 12.3), overall, with slight differences by race/ethnicity. Gestational diabetes was associated with lower likelihood of glycemic control (aHR: 0.85, 95% CI: 0.79 0.92), with the largest negative influence among Black (aHR: 0.77, 95% CI: 0.68, 0.88) and Hispanic (aHR: 0.84, 95% CI: 0.74, 0.95) individuals. Adjustment for screening bias and loss to follow-up modestly attenuated-racial/ethnic differences in diabetes risk but had little influence on glycemic control.

Conclusions. Understanding racial/ethnic differences in the influence of gestational diabetes on diabetes progression is critical to disrupt lifecourse cardiometabolic disparities.
Effect of Early Glycemic Control in Youth-Onset Type 2 Diabetes on Longer-Term Glycemic Control and β-Cell Function: Results from the TODAY Study
Authors: J Nadeau Kristen , El ghormli Laure , Arslanian Silva , Bacha Fida , Caprio Sonia , Chan Christine , C Chao Lily , Isganaitis Elvira , Rayas Maria , K Siska Maggie , Zeitler Philip , TODAY Study Group the
Published: June 2023

  

Objective: Little is known about the impact of early attainment of tight glycemic control on long-term β-cell function and glycemic control in youth-onset type 2 diabetes. We examined the effect of the initial 6 months of glycemic control on β-cell function and glycemic control longitudinally over 9 years, and the impact of sex, race/ethnicity, and BMI on these relationships in adolescents with youth-onset type 2 diabetes in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study.

Research Design and Methods: Oral glucose tolerance tests were performed longitudinally through year 9 to derive estimates of insulin sensitivity and secretion. Early glycemia was defined as mean HbA1c during the first 6 months post-randomization, categorized into 5 HbA1c groups (<5.7%, 5.7-<6.4%, 6.4-<7.0%, 7.0-<8.0%, and ≥8.0%). The long-term period was defined as the period between years 2-9. 

Results: 656 participants (64.8% female, baseline mean age 14 years, diabetes duration <2 years) had longitudinal data available over an average of 6.4±3.2 years of follow-up. HbA1c significantly increased in all early glycemic groups during years 2-9, with a steeper increase (+0.40%/year) among participants with the tightest initial control (mean early HbA1c<5.7%), in parallel to a decline in the C-peptide derived disposition index. Nevertheless, the lower HbA1c categories continued to have relatively lower HbA1c over time. 

Conclusions: Early tight glycemic control in TODAY was related to β-cell reserve, and translated to better long-term glycemic control. However, tight early glycemic control on the randomized treatment in TODAY did not prevent deterioration of β-cell function. 
Intra-articular injection of secretome, derived from umbilical cord mesenchymal stem cell, enhances the regeneration process of cartilage in early-stage osteo-arthritis: an animal study
Authors: Lubis Andri Maruli Tua , Aprianto Petrus , Pawitan Jeanne Adiwinata , Priosoeryanto Bambang Pontjo , Dewi Tri Isyani Tungga , Kamal Achmad Fauzi
Published: June 2023

Background and purpose: Mesenchymal stem cells (MSCs), both endogenous and exogenous, enhance chondrocyte proliferation by stimulating collagen type II. Secretome, an MSC derivate, has shown to also provide this mechanism through a paracrine effect. We aimed to evaluate the use of secretome and MSC in the management of early osteoarthritis (OA).Animals and methods: 19 (1 control) male sheep (Ovies aries), which were operated on with total lateral meniscectomy to induce knee OA, were divided into 3 groups: the secretome group, hyaluronic acid group, and MSC group. Each group was injected with the respective substances and was evaluated macroscopically and microscopically. The Osteoarthritis Research Society International (OARSI) score was calculated for all subjects and a descriptive and comparative statistical analysis was undertaken.Results: The macroscopic analysis of the treated groups revealed better OARSI score in the secretome group compared with the other 2 groups. The secretome group showed a significantly better microscopic score compared with the hyaluronic acid group (mean difference [MD] 6.0, 95% confidence interval [CI] 0.15–12), but no significant difference compared with the MSC group (MD 1.0, CI –4.8 to 6.8).Conclusion: Intra-articular injection of secretome is effective in managing early-stage osteoarthritis in the animal model compared with hyaluronic acid and has similar efficacy to MSC injection.
Increasing risk of revision due to infection after primary total hip arthroplasty: results from the Nordic Arthroplasty Register Association
Authors: Dale Håvard , Fenstad Anne Marie , Hallan Geir , Overgaard Søren , Pedersen Alma B , Hailer Nils P , Kärrholm Johan , Rolfson Ola , Eskelinen Antti , Mäkelä Keijo T , Furnes Ove
Published: June 2023

Background and purpose: The incidence of periprosthetic joint infection after total hip arthroplasty (THA) may be increasing. We performed time-trend analyses of risk, rates, and timing of revision due to infection after primary THAs in the Nordic countries from the period 2004–2018.Patients and methods: 569,463 primary THAs reported to the Nordic Arthroplasty Register Association from 2004 to 2018 were studied. Absolute risk estimates were calculated by Kaplan–Meier and cumulative incidence function methods, whereas adjusted hazard ratios (aHR) were assessed by Cox regression with the first revision due to infection after primary THA as primary endpoint. In addition, we explored changes in the time span from primary THA to revision due to infection.Results: 5,653 (1.0%) primary THAs were revised due to infection during a median follow-up time of 5.4 (IQR 2.5–8.9) years after surgery. Compared with the period 2004–2008, the aHRs for revision were 1.4 (95% confidence interval [CI] 1.3–1.5) for 2009–2013, and 1.9 (CI 1.7–2.0) for 2014–2018. The absolute 5-year rates of revision due to infection were 0.7% (CI 0.7–0.7), 1.0% (CI 0.9–1.0), and 1.2% (CI 1.2–1.3) for the 3 time periods respectively. We found changes in the time span from primary THA to revision due to infection. Compared with 2004–2008, the aHR for revision within 30 days after THA was 2.5 (CI 2.1–2.9) for 2009–2013, and 3.4 (CI 3.0–3.9) for 2013–2018. The aHR for revision within 31–90 days after THA was 1.5 (CI 1.3–1.9) for 2009–2013, and 2.5 (CI 2.1–3.0) for 2013–2018, compared with 2004–2008.Conclusion: The risk of revision due to infection after primary THA almost doubled, both in absolute cumulative incidence and in relative risk, throughout the period 2004–2018. This increase was mainly due to an increased risk of revision within 90 days of THA. This may reflect a “true” increase (i.e., frailer patients or more use of uncemented implants) and/or an “apparent” increase (i.e., improved diagnostics, changed revision strategy, or completeness of reporting) in incidence of periprosthetic joint infection. It is not possible to disclose such changes in the present study, and this warrants further research.