bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of DNA Versus Collagen Perception in Scientific Articles Examining Cancer Chemotherapy: Implication for Collagen-Based Approaches
Authors: KARAMAN Şule , KARAÇAY Özge , DİZDAR Yavuz
Published: March 2022

Objective: Although cancer chemotherapy has been used for more than seventy years, its definitive mechanism of action is not known. Many studies indicate that beyond DNA the collagen connective tissue matrix is also affected. This database analysis aims to determine the extent of DNA versus collagen perception in scientific papers indexed under PubMed.

Materials and methods: The PubMed database scanned on September, 15, 2021 using following keywords and combinations; "cancer", "cancer chemotherapy", "cancer chemotherapy AND damage”, “chemotherapy AND mechanism AND damage”, "chemotherapy AND clinical" as nominator. The number of items found for each search was proportioned in terms “DNA versus collagen” and the ratio was accepted as the perception shift coefficient.

Results: Tested with the p1-p2 analysis to calculate the difference between the two proportions in both search items. Based on the main rule under the assumption that “all cells have DNA and all cells live in the collagen matrix”. In the p1-p2 analysis of the data, a significant (p <0.001) difference was obtained for all dichotomy scans.

Conclusion: This data analysis supports the argument that both cancer and chemotherapy perception is DNA-based rather than collagen, since the synthesis and degradation process of very slow; it is not possible to observe it in short term studies. Chemotherapy should be further analyzed by this manner in purpose of collagen matrix.
La fabrique de l’autorité publique dans le bazar de Karachi : apolitisme, piété et ethos de la confrontation
Authors: Russo Sophie
Published: March 2022

Quels sont les ancrages sociaux de la fabrique de l’autorité publique dans des contextes marqués par la violence et l’incertitude ? À partir d’une enquête de terrain conduite auprès des leaders de marchands dans le bazar de Karachi, j’explique en quoi l’adhésion à un style de vie constitue un mode efficace d’exercice de la domination. Si d’aucuns affirment que l’autorité publique se forme et se maintient souvent dans la violence, je souligne que les acteurs qui évoluent dans des situations de conflit valorisent des modes d’action, tels que la confrontation non violente, qui permettent de défendre des intérêts sans pour autant alimenter les tensions. Pour construire leur autorité, ces leaders privilégient également les registres de légitimation vernaculaires, notamment l’apolitisme, donc l’absence supposée de compromission avec le monde du crime, et la piété, qui va de pair avec l’honnêteté et le respect de la morale islamique dans la conduite des affaires. Ainsi l’autorité de ces leaders s’inscrit-elle à la fois dans les normes propres aux milieux marchands de Karachi et dans l’environnement urbain dans lequel ils travaillent.
Approfondissement du soi et élargissement du soi : une nouvelle clé de lecture pour le «  One Health  »
Authors: Priaulet Isabelle
Published: March 2022

En réponse à l’intervention d’Éric Charmetant, cet article envisage la façon dont, chacun à leur manière, Hans Jonas et Arne Næss, considèrent le milieu naturel comme une thérapie face à la menace ontologique que fait peser sur notre humanité l’expansion sans limite de la culture technicienne. À partir des notions « d’élargissement du Soi » et « d’approfondissement du Soi » élaborées dans sa thèse sur la « conversion écologique », l’auteur donne une lecture originale de ces auteurs et revisite la notion de «  One Health  » dans sa dimension à la fois cosmique et intime.
Métaphores éthiques d’artefacts détournés dans la Bible
Authors: Perrin Jérôme
Published: March 2022

Après une réflexion sur la possibilité de métaphores éthiques portées par des artefacts et sur la médiation éthique par la technique, on analyse comment certains artefacts, « détournés » quant à leur apparence, leur usage ou leur contexte d’utilisation dans la Bible, par des récits, des prophéties ou des exhortations, peuvent être des métaphores du salut et des métaphores éthiques. À partir de quatorze exemples on repère à chaque fois comment c’est le détournement de l’artefact qui vient critiquer l’éthique de la puissance, de la performance et du mensonge qui caractérisent la technique en tant que telle, et qui suscite alors une éthique des valeurs et des vertus, en fidélité à la Parole de Dieu.
Quand la vie devient non préférable : vieillir et ses effets sur l’usage de soi chez les Stoïciens
Authors: Monteils-Laeng Laetitia
Published: March 2022

Le stoïcisme voit dans la vieillesse une circonstance indifférente n’interdisant pas le bonheur. La vieillesse peut toutefois rendre la mort préférable (Sénèque, Lettre 58 ; Marc-Aurèle, Pensées III, 1), quand elle signifie souffrir de façon excessive ou sombrer dans la démence ( lêros ) ( SVF III, 768). À travers la question de l’éventuelle incidence du vieillissement corporel sur nos fonctionnalités psychiques, c’est le problème des rapports, voire des interférences âme-corps chez les stoïciens que nous souhaitons reprendre à nouveaux frais. Après avoir remis en question l’homogénéité pneumatique du corps humain et notre capacité en tant qu’être rationnel à contrôler tous ses processus métaboliques, on tentera de reconstituer une théorie stoïcienne du vieillissement, pour en mesurer l’impact possible sur notre capacité à user de notre hégémonique.
An Overview of Comparison between Construction Contracts in Malaysia: The Roles and Responsibilities of Contract Administrator in Achieving Final Account Closing Success
Authors: Zakaria Zarabizan Bin , Ismail Syuhaida Binti , Yusof Aminah Binti Md
Published: March 2022

The administration of construction contracts in Malaysia is facilitated through a standard form of contract. The application of each however depends on the type of project, mode of finance and owner of the project. International Federation of Consulting Engineers (FIDIC), Public Work Department 203A (PWD203A), Pertubuhan Akitek Malaysia (PAM) Standards form of contract are widely implemented in Malaysia. In generally, each standard form of contract aims at ensuring effective, efficient and non-disputable contract administration. Nonetheless, variations arise in certain matters. This paper appraises the differences in roles and responsibilities of contract administrator as stipulated in each forms, namely PWD203A, PAM and FIDIC via literature review on some different types of forms of contract used in Malaysia. This aim can be achieved by determining the important factors affecting final account closing success caused by contract administrator, and investigating the differences between forms of contract. The understanding of these roles and responsibilities is important at the preliminary stage especially in selecting superintending party as well as identifying the contract liability in the persuasion of the contract. This paper shows that the use of contract documents either FIDIC, PAM and PWD 203A is dependent on the project owner/employer, type of project as well as the nature of a project and financing involved. Most of the projects under the government will apply PWD203A contract document while the private sector will use PAM contract document and FIDIC contract document will be used for projects involving international contracts.
Enhanced Reputation-based Tit-for-Tat Strategy for Collaborative Social Applications
Authors: Al-Dhanhani Ahmed , Otroky Hadi , Mizouniy Rabeb , Al-Rubaie Ahmad
Published: March 2022

Social applications have witnessed a rapid growth in their use. Millions of people are utilizing them on a daily basis in order to share their experience, information and to communicate with their family members and friends. Lately, these technologies have been used to foster collaboration in education, however, it is a case of hit and miss and without established techniques to ensure or replicate success. One known problem that can impact the sustainability of collaborative social applications is the presence of selfish users. A selfish user adopts a free riding behaviour that takes advantage of the collaborative group without contributing back which would affect the group’s survivability. However, the inability to contribute back is not necessarily due to selfishness. In fact, cooperative learners may avoid participating due to the lack of expertise and/or confidence. In the literature, repeated non-cooperative game theory was introduced as a solution where several strategies were introduced to identify selfish users. However, such strategies do not differentiate between selfish learners and cooperative learners who are reluctant to answer others’ requests either due to lack of knowledge or confidence. In this paper, we show that educational and collaborative groups need to distinguish between those types of users and put in place mechanisms to encourage non contributing cooperative learners to participate rather than punishing them and excluding them from the group. An enhanced reputation-based Tit-for-Tat strategy is proposed as a solution that will enhance the group activity and overall gain.
A Modern Support For Training Geodetic Students In Romania
Authors: Didulescu Caius , Savu Adrian , Coşarcă Constantin , Sărăcin Aurel , Badea Gheorghe , Badea Ana Cornelia , Negrilă Aurel
Published: March 2022

Through the e-learning system called “geodesyinstruct”, Technical University of Civil Engineering Bucharest offers its students a modern learning tool in geodetical domain, an online collaboration platform integrated with an e-Learning system, allowing the use of digital course modules, interactive teaching and student centered learning, thus ensuring potential to enhance access and participation in higher education.
Home hospital care through telehealth during COVID-19 pandemic in Nepal
Authors: Devkota Ashok , Pandey Sagar , Pandey Yadav , Neupane Hari , Basnet Anjan Kumar , Shah Anish , Thakur Rahul , Sah Sumit , Chaudhary Durgesh , Mahato Aakash , Acharya Shradha , Paudel Prakash , Pathak Amrit , Acharya Yam
Published: March 2022

COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 has been occurring in waves due to emergence of different strains. During second wave of COVID pandemic in Nepal, largely caused by Delta variant, due to rapid rise in cases, existing hospitals and health facilities were overwhelmed. As a result, telemedicine was expanded to help reduce strain on the healthcare system and meet unusually high demands. A team of physicians with the support from the local government provided hospital level care for patients at home in rural district of Dang in Nepal. This research analyzes implementation of this model of care and outcomes based on review of patient records and treatment guidelines. Within a month, from May 5 to June 13, 2021, a total of 102 patients received care at home. While most patients had mild to moderate disease, 12.8% of patients had severe disease. Telemedicine usage was highest among the 40-59 years age group, with overall recovery rate of 85.3%. The patient satisfaction survey revealed that majority, 86.5% were happy with the medical care they received. This home hospital care model has shown excellent clinical outcomes and high patient satisfaction even in resource limited setting.
Association of tumor necrosis factor-alpha promoter region gene polymorphism at positions -308G/A, -857C/T, and -863C/A with etanercept response in Iraqi rheumatoid arthritis patients
Authors: Mohammed Samer , Zalzala Munaf , Gorial Faiq
Published: March 2022

Objectives: This study aims to evaluate the association between polymorphisms in the promoter region of the tumor necrosis factor-alpha (TNF-α) gene at locations -308G/A, -857C/T, and -863C/A with the tendency of being non-responder to etanercept.

Patients and methods: Between October 2020 and August 2021, a total of 80 patients (10 males, 70 females; mean age: 50 years; range, 30 to 72 years) with rheumatoid arthritis (RA) receiving etanercept for at least six months were included. The patients were divided into two groups responders and non-responders, based on their response after six months of continuous treatment. Following polymerase chain reaction amplification of the extracted deoxyribonucleic acid, sequencing by Sanger method was performed to identify the polymorphism at the TNF-α promoter region.

Results: In the responder group, the GG genotype of (-308G/A) and the AA genotype of (-863C/A) were both significantly present. The CC genotype of (-863C/A) was significantly present in the non-responders group. The CC of (-863C/A) SNP was the only genotype that appeared to increase the likelihood of being resistant to etanercept. The GG genotype of (-308G/A) was negatively correlated with the likelihood of being a non-responder. The (-857CC) and (-863CC) genotypes were significantly more prevalent in the non-responders group.

Conclusion: The presence of the (-863CC) genotype, alone or in combination with (-857CC), is linked to an increased likelihood of becoming a non-responder to etanercept. The GG genotype of -308G/A and the AA genotype of -863C/A significantly increase the likelihood of becoming responder to etanercept.
ESPAsync Web Server to Control Multiple Sensor Reading: A Review
Authors: J Nagaraja , B R Akash , YM Suhaan , Teja Y Surya , C Nagatarun
Published: March 2022

SDN (Software-Defined Networking) is a new networking architecture that is enterprising, feasible, cost-effective and robust applications. This approach decouples network management and forwarding operations, allowing network control to be directly programmable while the underlying infrastructure is veiled for applications and network services. MQTT is a lightweight publish-subscribe network protocol for sending and receiving messages. It is made for communications with remote places when there are resource limits or network capacity limitations. The ESP8266EX-based NodeMCU development board is a small module that has a microcontroller, integrated Wi-Fi receiver, and transmitter. The findings of the performance evaluation show that IoT devices' computational overhead and energy consumption are decreased, as well as the total time of the handshake.
Pediatric Restorative Option for Congenitally Missing Anterior Teeth: A Carolina Bridge Case Series
Authors: Chaitanya P Puranik , Sheaffer Yinger , Vilhelm G Ólafsson
Published: March 2022

Congenital absence of permanent maxillary lateral incisors can have a negative impact on adolescent patients from a functional and psychological standpoint. Historically used treatment options for hypodontia are invasive, warranting preparation of the abutment teeth and/or comprehensive orthodontic treatment. Dental implants are a preferred modality without the need for abutment preparation; however, are contraindicated until the completion of skeletal growth. This case-series presents two case-reports of adolescent patients with congenitally missing permanent maxillary lateral incisors restored using a novel resin-bonded bridge(Carolina Bridge). The Carolina Bridge is a conservative, esthetic, cost-effective, reversible, long-term, interim treatment option to replace missing teeth until implant-supported restorations are indicated. The basics of the Carolina Bridge including indications, contraindications, case selection criteria and clinical fabrication steps are presented in detail to help clinicians with treatment planning and execution.
Kadar Protein Pada Tempe Bersumber Dari Kacang Kedelai Hasil Perendaman Bonggol Nanas (Ananas comosus (Linn) Merrill)
Authors: Putri Yenni Aulia , Agustina Elita , Ceriana Ria
Published: March 2022

Pineapple is one of the fruits consumed by the community. Pineapple produces waste in the form of pineapple weevils which are thrown away for nothing. Pineapple weevil can be used as a medium for soaking soybeans in the process of making tempeh. The purpose of this study was to determine the effect of pineapple weevils to increase tempeh protein content, to determine the duration of soaking soybeans in pineapple cone juice which was effective in increasing tempeh protein content, and to determine the feasibility of a reference from the results of research on the effect of soaking soybean seeds in pineapple weevil juice to increase protein content in tempe. The research design used was a completely randomized design (CRD) with 6 treatments and 4 replications, namely P1 (5 hours of immersion), P2 (6 hours of immersion), P3 (7 hours of immersion), P4 (8 hours of immersion), P5 (9 hours of immersion). ) in pineapple weevil juice, and P0 (12 hours of immersion in distilled water as a control). Protein content testing was carried out using the Kjeldahl method through a process of digestion, distillation, and titration carried out at the Goods Quality Testing and Certification Center (BPSMB). Analysis of the protein content data obtained used the ANOVA method and carried out the BNJ further test. The results of data analysis showed an increase in protein content in tempeh soaked with pineapple weevil juice at P1 of 17.39% and showed that the most effective soaking time was 5 hours in pineapple weevil juice
Faktor-Faktor yang Mempengaruhi Kurangnya Kesadaran Mahasiswi AKBID Saleha Terhadap Penggunaan Masker di Masa Pandemi COVID-19 di AKBID Saleha Banda Aceh Tahun 2021
Authors: Mauliati Desria
Published: March 2022

The use of masks is one of the health protocols that must be followed by everyone with discipline. The results of monitoring Compliance with Health Protocols for wearing masks on female students at the Saleha Midwifery Academy Banda Aceh in 2021 are around 75% of all grades 1,2 and 3 students. Research Objectives: to determine the effect of knowledge, environment and behavior on female students at AkbidSaleha Banda Aceh. Research Methods: This study used an analytical method with a Cross Sectional approach which was carried out on 26-27 August 2021. The population in this study were all AkbidSaleha students who totaled 92 people. Sampling using total sampling.Analysis of data using univariate and bivariate analysis with the chi-square method. Results: The results of statistical tests with Chi-Square obtained p Value = 0.000 <0.05, there is an effect of knowledge of student AkbidSaleha with a lack of awareness of the use of masks. While the results of statistical tests with Chi-Square obtained p Value = 0.000 <0.05, there is an environmental influence with a lack of awareness of the use of masks in AkbidSaleha students. And the results of statistical tests with Chi Square obtained p value = 0.000 <0.05, there is an influence of behavior with a lack of awareness of the use of masks in AkbidSaleha students
AÇÕES DE ENFERMAGEM NA CONSTRUÇÃO DE UMA RELAÇÃO HUMANIZADA COM PAIS DE RECÉM-NASCIDOS INTERNADOS EM UTI NEONATAL
Authors: Teixeira Leandro Barbosa , Apolinário Joelma Maria dos Santos da Silva , Alves de Sousa Santos Allan Bruno , Coêlho Luana Pereira Ibiapina , Azevedo Sostenise Maciel de , Kretzer Olívia Cássia , Evangelista Natalia Maria Chagas , Rocha Ane Grazielle da Silva , Ferreira Rosinei Nascimento , Menezes Carliane de Sousa Medeiros e , Coimbra Larissa Lima Marques , Filho Luiz Cláudio Galera de Oliveira , Cunha Ronny Soares da , Silva Mariane Nascimento Domingues da
Published: March 2022

O Trabalho tem como principal objetivo: Identificar como o enfermeiro pode contribuir para a interação com a equipe de enfermagem junto a família na UTI-NEONATAL. O estudo surgiu a partir da observação acadêmica do grupo na Unidade de Terapia Intensiva Neonatal, onde realizamos visitas técnicas. Observamos o exercer da função dos enfermeiros neonatologistas deste serviço. Nossa motivação foi descrever o processo de comunicação entre o enfermeiro e pais de RNs durante o período de internação nas unidades de terapia intensiva neonatal, devido a evidências de uma relação pouco humanizada do enfermeiro junto aos pais. Observamos que os enfermeiros se mostram um pouco distante dos pais, não conseguindo perceber suas necessidades e expectativas frente à hospitalização de seu filho em uma Unidade de Terapia Intensiva. Os enfermeiros, membros da equipe da UTI Neonatal devem ser o elo entre os pais e seus filhos. O compromisso de ajudar os pais a vencer as dificuldades encontradas e encorajá-los nessa aproximação para que se inicie o processo de desenvolvimento da humanização. É necessário nesse contexto perceber o quanto é importante a disponibilidade para ouvir o outro, pois só desta forma que a humanização acontecerá de forma efetiva. Metodologia: trata-se de uma revisão integrativa visando como o enfermeiro pode trazer na prática a interação com a equipe de enfermagem junto à família na UTI- Neonatal. Concluímos que os enfermeiros e a equipe de enfermagem que atua em UTIN precisam sistematizar seus cuidados pautados na inclusão das famílias na unidade da terapia intensiva neonatal.
University lecturers' perceptions of the role of English in their teaching
Authors: Tuomainen Satu
Published: March 2022

This paper describes international university lecturers’ perceptions about the role of English in their teaching. The lecturers (N=31) of a Finnish university, representing 20 nationalities, attended a pedagogical development course intended to enhance their understanding of communicative skills used in teaching and English-medium instruction (EMI). University programmes with EMI have tripled in the last decade in Europe (Richter, 2019), yet the focus of university lecturers is rarely on the language but on the content (Doiz & Lasagabaster, 2021). A pre-course written reflection task was used to determine how the lecturers defined communicative teaching and the role of EMI in their teaching. Post-course, following teaching demonstrations and peer feedback, the lecturers completed another reflective written task to examine if their approach to EMI had altered. The results indicate that most international university lecturers, both non-native and native speakers of English, pre-course viewed the role of EMI as minimal in their teaching as they expected students to be able to study their field in English. In the post-course analysis, however, many lecturers noted that they had become more conscious of their language use, rate of speech and clarity to be more mindful of their students studying in another language. The study suggests that university lecturers should increase awareness of their use of English in EMI to enhance the quality of their communication and teaching to support students’ learning in a second language.
Designing a Pipeline for Predicting Power Grid Stability with Artificial Neural Network (ANN)
Authors: Prusty Sushree Gayatri Priyadarsini , Prusty Sashikanta
Published: March 2022

Renewable energy sources are becoming more popular, providing a much-needed alternative to traditional, limited, and climate-unfriendly energy sources. Wireless sensors, cloud computing, cyber security, and wide-area monitoring are basic communication and control technologies for smart grid applications. Design of communication and control architectures for the adoption of smart energy grids for rural loads and distributed energy, including energy storage solutions. In this work, a Machine Learning module called scikit-learn is used for pre-processing of labeled input data by using StandardScaler, KFold for cross-validation, and Confusion matrix for measuring performance. Also, the ML technique uses the binary classification method to divide the ‘stabf’ data into two parts as stable and unstable. Here deep learning-based Artificial Neural Network (ANN) has been used to evaluate the result and to predict new grid data to enhance stability. ANN takes 12 input nodes in the input layer and three hidden layers out of which two hidden layer takes 24 nodes and another one takes 12 nodes and an output layer consisting of a single node. Adam optimizer has been used for model compilation and loss function calculation ‘binary_crossentropy’ is used. Finally, after successful completion of the evaluation process, this model gives a test accuracy result of 98.33%.
Synthesis, Characterization, In vitro Antiproliferative and Cytotoxic Effect of Ruthenium(II)-Bipyridine-Benzoylpicolinic Acid Complex on SK-MEL-28 and Normal L6 Cell Lines
Authors: Sivaraman Santhiya , Daniel Sheeba
Published: March 2022

The most seriously spread malignant tumor of melanocytes throughout the body is a melanoma type of skin cancer. SK-MEL-28 cell line is one of a series of melanoma cell lines. The objective of the present investigation is to study the anticancer activity and cytotoxicity of novel [Ru(bpy)2(bzpic)2]2+ (bpy = 2,2ʹ-bipyridine and bzpic = 3-Benzoylpicolinic acid) complex on SK-MEL-28 and normal L6 cell lines using MTT assay method. The morphology of the cancerous SK-MEL-28 cell line at various concentrations of the [Ru(bpy)2(bzpic)2]2+ complex is assessed by 2-fold dilution method, and the in vitro antiproliferative effect of the complex on the cancerous SK-MEL-28 cell line is analyzed by direct microscopic observation method. The percentage viability of the complex on cancerous SK-MEL-28 cell line at various concentrations is determined. The IC50 value of the complex against the SK-MEL-28 cell is found to be 39.109 µg/mL which shows good antiproliferative effect. The IC50 value of the complex against normal L6 cell line is found to be 55.315 µg/mL. The results revealed that the percentage of growth inhibition of the cell is based on dose-dependent manner and the formation of formazan crystal indicates this. The fluorescent microscopy observation clearly determines that the synthesized [Ru(bpy)2(bzpic)2]2+ complex shows late apoptosis on SK-MEL-28 cell line and early apoptosis on L6 cell line. Hence, it is evident that the synthesized complex exhibits good in vitro antiproliferative effect with lower cytotoxicity.

HIGHLIGHTS

Synthesis of [Ru(bpy)2(bzpic)2]2+ complex

Direct and fluorescent microscopic observation of [Ru(bpy)2(bzpic)2]2+ complex on SK-MEL-28 and normal L6 cell lines

In vitro antiproliferative and cytotoxic effects of [Ru(bpy)2(bzpic)2]2+ complex on SK-MEL-28 and normal L6 cell lines

GRAPHICAL ABSTRACT
Effect of Feeding Different Levels of Corn Silage on Milk Yield and Quality in Dairy Assaf Ewes
Authors: Zaazaa Ahmed , Sabbah Mohammed , Qubbaj Tawfiq , Omar Jamal Abo
Published: March 2022

This study aimed to investigate the impact of feeding by different corn silage (CS) proportions on ewes milk yield and fatty acids composition. Twenty-one lactating Assaf ewes were divided into 3 groups (7 ewes each). The following dietary treatments based on increasing the proportion of CS in the total mixed ratio (TMR) were tested; (1) 47 % AH (0 % CS in the TMR) correspond to 0 % CS, (2) 23.5 % AH (23.5 % CS in the TMR) correspond to 50 % CS, and (3) 0 % AH (47 % CS in the TMR) correspond to 100 % CS. After 8 weeks of feeding, the type of diet had no significant effect on milk yield and solid; however, it significantly affects the milk fat. The levels of C8:0 and C14:0 were not affected by different silage levels. While the C10:0 and C12:0 significantly increased when fed on a 100 % CS diet. However, a significantly lower level of C16:0 (33.22 %) was observed in the 100 % CS compared to feeding on silage at 50 and 0 % (40.66 and 37.98 %, respectively). Similar trend was observed for C18:0, the lowest was in 100 % CS compared with the different feeding diets (7.52, 12.69, 10.61 % for 100, 50, 0 %, respectively). Total USFA in milk were decreased (p < 0.05) by feeding 100 and 50 % CS compared to 0 % CS feeding. It can be concluded that the replacement of alfalfa with CS had some influence on milk composition, especially the fatty acids profile.

HIGHLIGHTS

Utilization of nonconventional feed ingredients is important to reduced feed cost and improving its nutritive value

Milk composition, especially the fatty acids profile when replaced portions of alfalfa can be affected by feeding corn silage

More research is needed to confirm our findings
Natural Frequencies of Beams with Axial Material Gradation Resting on Two Parameter Elastic Foundation
Authors: Kumar Saurabh
Published: March 2022

Free vibration analysis is carried out on axially inhomogeneous beams resting on Winkler-Pasternak elastic foundation. The material properties of the beam like Young’s modulus, modulus of rigidity and material density are considered to be varying along the length direction following constant, linear and exponential material models. The beam is subjected to different combinations of clamped and simply supported boundary conditions. The formulation is based on Timoshenko beam theory and energy method along with Hamilton’s principle is used to derive the governing equations. The effect of material gradation and the 2 parameters of elastic foundation on the natural frequencies are studied in detail. The present results are validated by comparing them with established ones and satisfactory matching is observed.

HIGHLIGHTS

Free vibration behavior of axially functionally graded beams in investigated

Three different material models and three boundary conditions are considered

Effect of two parameter elastic foundation is considered

Timoshenko beam theory and Rayleigh Ritz method are employed

It is found that the stiffness of elastic foundation significantly affects the natural frequency of the beam

GRAPHICAL ABSTRACT
The Effect of Traditional Thai Massage on Quality of Sleep in Adults with Sleep Problem
Authors: Chompoopan Warangkana , Eungpinichpong Wichai , Chompoopan Worawut , Sujimongkol Chinakorn
Published: March 2022

Sleep problem or insomnia is one of the most common causes of health problems, affecting around 10 - 20 % of the world population. Traditional Thai massage (TTM) is a popular alternative treatment in Thailand for reducing fatigue and improving sleep quality. This study aimed to examine the effect of traditional Thai massage on sleep quality in adults. Twenty-eight adults with poor sleep quality (based on Verran and Snyder-Halpern sleep scale) participated. They were randomly allocated into a control group (n = 14) and a TTM group (n = 14). Participants in the TTM group received three 90-min whole body traditional Thai massage sessions within one week, whereas the control group participants maintained their daily lives. Quality of sleep was assessed before and a day after the massage sessions. The outcome measure was the Verran and Snyder-Halpern sleep scale. The within-group data was analyzed by Paired t-test, whereas ANCOVA did the between-group data. 

The results showed that the participants in the TTM group had significantly decreased score of sleep disturbance (31.63 ± 2.95 vs 45.47 ± 3.24, p < 0.001) and increased the effectiveness score (70.73 ± 7.33  vs 53.47 ± 4.23, p < 0.001) after the last session of massage as compared to those of the control group. We conclude that TTM could significantly improve sleep quality without any adverse effects.

HIGHLIGHTS

The overall prevalence of insomnia in Thai adults was 40.8 % and is commonly found in the Thai population

Sleep quality was associated with all the academic performance in adolescents and cognitive function in adults

Traditional Thai massage could significantly improve sleep quality without any adverse effects

Since this treatment is generally safe and comfortable, it could be used as an alternative therapy to treat people with sleep problems

GRAPHICAL ABSTRACT
Osimertinib (Tagrisso)
Authors: Reimbursement Team
Published: March 2022

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses osimertinib (Tagrisso), 40 mg and 80 mg tablets, orally.
Indication: As adjuvant therapy after tumour resection in patients with stage IB to stage IIIA non–small cell lung cancer whose tumours have EGFR exon 19 deletions or exon 21 (L858R) substitution mutations.
Reproductive success of threatened northern Lesser Black Backed Gulls (Larus fuscus fuscus) in relation to nest predation by Ravens (Corvus corax)
Authors: Bustnes Jan Ove , Helberg Morten , Bårdsen Bård-Jørgen
Published: March 2022

Many seabird populations suffer heavily from the destruction of nests by generalist predators. In this study, we analyzed 16 years of data (2005–2020) on the reproductive output of the northern Lesser Black-backed Gull (Larus fuscus fuscus) at Horsvær, the largest assemblage of this subspecies in Norway (up to ca. 400 pairs), in relation to the occurrence of breeding Ravens (Corvus corax). A pair of Ravens were firstly discovered at Horsvær in 2010, and between 2011 and 2016 they were observed with broods (2–5 fledglings) in most years. Between 2017 and 2020, human intervention prevented the Ravens from breeding in the colony. However, in 2020 a pair of Ravens brought their fledglings over from a neighboring island in the middle of the incubation period for the gulls. On average, the nest predation rate was 43% when Ravens had fledglings within the study area. In contrast, only 10% of nests were depredated in years when Ravens did not reproduce successfully or were absent. Moreover, only 0.07 fledglings were on average produced per nest in years when Ravens bred successfully, compared to 0.71 fledglings per nest in years with no Raven reproduction. A high level of nest predation led to a decline in the number of nesting gulls, which was not observed in a neighboring Raven-free colony. Finally, in years with high Raven predation at Horsvær, production of fledglings was still high in yet another nearby Lesser Black-backed Gull colony. The Ravens were established at Horsvær in the absence of people in the spring, and the only option to save these threatened gulls may be to prevent the Ravens from nesting successfully in or near their colonies.
DA EFETIVIDADE DO TEXTO LEGISLATIVO NA PROTEÇÃO DA COMUNIDADE LGBTQIA+
Authors: Cremer Maria Oderlândia Duarte , Faria Emerson Oliveira de
Published: March 2022

O presente artigo busca realizar uma análise qualitativa das disposições encontradas nas fontes do direito para averiguar se a presença ou ausência da definição dos grupos que compõem a comunidade LGBTQIA+ e de noções de identidade de gênero e orientação sexual são relevantes para a devida efetividade dos dispositivos legislativos aplicados ao caso concreto, buscando com mais enfoque na ação direta de inconstitucionalidade por omissão de número 26 e nas leis ordinárias e complementares. Também busca analisar o contexto fático e histórico-social nos quais a efetivação dos dispositivos legais é feita, para certificar-se se a efetividade dos dispositivos é afetada pelos servidores do Estado ou não.
TEOLOGIA DAS RELIGIÕES: NOVO PARADIGMA DO PENSAR TEOLÓGICO
Authors: Vicente José Armando
Published: March 2022

O tema da teologia das religiões vem ganhando a cada dia uma importância mais decisiva no cenário da reflexão teológica contemporânea. De fato, a teologia das religiões é um tema teológico recente. Podemos dizer que a ela teve seu nascimento na época do Concílio, ou seja, nos anos que lançaram suas premissas mais imediatas e nos que se seguiram. O tema é, portanto, extremamente complexo e sua abordagem exige um tratamento cuidadoso. A teologia das religiões estuda, à luz da fé cristã, a experiência comum  a toda a humanidade como uma “espera anônima” do mistério de Cristo. A teologia das religiões é parte integrante do discurso teológico da Igreja. Queremos alertar, aqui, que a teologia cristã das religiões, embora sendo necessariamente “confessional”, não deve, porém, ser provinciana ou bairrista. Pelo contrário, ela deve adotar uma perspectiva global que abarque, na sua visão, a totalidade da experiência religiosa da humanidade. Do ponto de vista da fé cristã surgem as seguintes questões: De que maneira as realidades em que as pessoas vivem sua vida religiosa entram no projeto de Deus para a salvação da humanidade? Aos olhos de Deus que significado tem a realidade do pluralismo religioso no mundo?
O COTIDIANO ESCOLAR E OS PROCESSOS DE GESTÃO NA ERA DIGITAL
Authors: Battistella Luciane Paula
Published: March 2022

Este Estudo de caso resulta de uma pesquisa sobre o cotidiano escolar e os processos de gestão e as tecnologias digitais, que hoje cada vez mais estão presentes em nossas escolas. Buscou-se entender quais os aspectos positivos e negativos que a tecnologia traz para o desenvolvimento de ações pedagógicas, e ao desenvolvimento do aprendizado nas entidades escolares. Os participantes da pesquisa, com dados qualitativos, coletados por meio de um questionário, foram professores de escolas de educação infantil. Como resultado algumas variáveis surgiram quanto a atualização do ensino, a capacidade do desenvolvimento de aulas online, bem como as ferramentas necessárias para o bom funcionamento de novas formas de ensinar através dos meios digitais.
الاتجاهات الحديثة في تسويق خدمات مؤسسات ومراكز المعلومات
Authors:   بكالوريوس في علم المعلومات، دبلوم عالي في التربية، المملكة العربية السعودية, الحربي نجاة عايض , باهبري رنا عمر ,   ماجستير في إدارة المعلومات، المملكة العربية السعودية, القثامي مرام محمد ,   ماجستير في إدارة المعلومات، المملكة العربية السعودية, تركستاني هالة عبد الرشيد ,   ماجستير في إدارة المعلومات، المملكة العربية السعودية
Published: March 2022

تهدف الدراسة إلى معرفة الاتجاهات الحديثة المستخدمة للتسويق لخدمات مؤسسات المعلومات، ومعرفة التجارب الحالية للمؤسسات المعلومات في استخدام التقنيات الحديثة، ومدى تأثير التقنية والشبكات الاجتماعية على مفهوم التسويق لخدمات المعلومات. حيث تم استخدام منهج تحليل المحتوى والاطلاع على التجارب الحالية في استخدام التقنيات الحديثة في التسويق لخدمات مؤسسات المعلومات ووجد أن التقنيات عديدة وتم استعراضها واستعراض النماذج المطبقة ومن ضمن التقنيات الحديثة الهولوجرام والواقع المعزز والعرض البانورامي وغيره. حيث توصلت الباحثات أن التقنيات الحديثة طريقة سريعة لنشر والترويج لخدمات ومؤسسات المعلومات بطريقة مبتكرة وملفته وتعتبر عامل جذب للمستفيدين وطريقة حديثة لكسب العملاء والمستفيدين، حيث أن قلة من مؤسسات المعلومات أدخلت التقنيات الحديثة للترويج لخدماتها، وتعتبر ثقافة التسويق لخدمات مؤسسات المعلومات تم اقتصارها على نشر الخدمات على حسابات مواقع التواصل الاجتماعي التابعة لمؤسسات المعلومات. وتوصي الباحثة: بتكثيف الجهود لاستخدام التقنيات الحديثة في التسويق والترويج للخدمات بإقامة الحملات وعرض الخدمات عن طريق هذه التقنيات لاستقطاب المستفيدين، والاطلاع المستمر على التقنيات الحديثة وعمل دراسة لمدى فعاليتها، والعمل على تدريب العاملين وإخصائي المعلومات على التعامل مع التقنية وتبني طرق التسويق الحديثة ومعرفة أساليب التسويق وتسخيرها لترويج لخدمات مؤسسات المعلومات.
The Impact of Obesity on Total Knee Replacement
Authors: Asif Syed , Alhazmi Hatim , Alrehaili Muaath , Tamim Husam , Alhusayni Ahmed , Almohammadi Marwan , Owaidah Omar
Published: March 2022

Worldwide estimates indicate the high prevalence of obesity and overweight, and some countries even consider it a pandemic. Obesity is correlated with many disorders like hypertension, diabetes, osteoarthrosis of the knee, and coronary artery disease. Many investigations have been published to study the impact of and correlation between obesity and total knee arthroplasty procedures. Evidence is contradicting regarding the perioperative outcomes in these patients. In the present study, we have conducted a literature review to elaborate on the effects of obesity on total knee arthroplasty. Obesity can be considered as the single modifiable risk factor for performing osteoarthritis-induced total knee arthroplasty. Evidence regarding the effect of obesity on the perioperative outcomes and revision approach following a total knee arthroplasty contradicts as many studies reported that the impact is not significant while others indicated the opposite. According to the various risks that obesity poses on the patients’ general condition and the potential adverse impact on the outcomes of the surgery, we recommended that weight gain should be conducted before the patient has been indicated to perform the surgery, which was also validated by previous investigations. However, evidence regarding this is still scarce in the current literature and further investigations are needed.
SEXUAL RISK BEHAVIOURS AND STI RISK PERCEPTION AMONG SENIOR HIGH SCHOOL STUDENTS IN THE SUNYANI MUNICIPALITY OF GHANA
Authors:   College Of Health Yamfo-Ghana, Barimah Antwi Joseph , Ibrahim Mohammed Mohammed ,   College Of Health Yamfo-Ghana, Nketiah Yaw Boakye ,   College Of Health Yamfo-Ghana, Amoah Bernard Opoku ,   College Of Health Yamfo-Ghana, Agyemang Larry ,   College Of Health Yamfo-Ghana, Dumba James ,   College Of Health Yamfo-Ghana, Gyamea Helina ,   College Of Health Yamfo-Ghana
Published: March 2022

In the ideal world scenario risky sexual behaviours are rampant. The most worrying part is the fact that teenagers and the youth are the ones with a high predisposition to indulge in risky sexual behaviours. This study assessed the risky sexual behaviour and the STI Risk Perception among senior high school students within the Sunyani municipality. A descriptive cross-sectional study design was deployed in order to get a clear picture of the relationship between risky sexual behaviour and attendant STIs. The targeted population was 250 students of the Twene Amanfo Senior High Technical School (TASTECH) in Sunyani- Ghana. In order to reduce bias, a simple random sampling was used in recruiting the 250 participants. A structured questionnaire was employed in obtaining quantitative data from the students. Statistical Package for the Social Sciences (SPSS version 25) was used to analyze the quantitative data. The results indicated that, 110 students (44% of respondents) indulged in various forms of sexual risk behaviours. A greater majority of 147 (78.8%) had low STI risk perception which is very disheartening. Sexual risk behaviours such as early sexual initiation (OR 7.462, CI: 4.143 – 14.096), having multiple sexual partners (OR 43.669, CI: 20.825 – 91.573), non-condom use (OR 6.368, CI: 3.456 – 11.735) and the use of drugs (OR 15.523, CI: 8.226 – 29.292) were strongly associated with the likelihood of contracting sexually transmitted infections. The study, therefore, recommends that there should be a rigorous mass sensitization campaign across all Senior High schools in Ghana to create more awareness among young people on the dangers associated with indulging in risky sexual behaviours.
History of Intermittent Mandatory Ventilation 1971 to present. Part two
Authors: Sanderson Ron , Rogers Cheryl
Published: March 2022

Medical history is often overlooked as advances keep moving forward. Seldom is it that advances in medicine are truly new, unique ideas, but rather built on ideas that have been considered before. Even our latest developments will become history or forgotten as science and medicine advance. This history of intermittent mandatory ventilation (IMV) is a two-part article in which the first part attempts to show that the concepts and apparatus that involve the now common mode of ventilation have been considered and described for nearly 200 years, if not earlier. This older history is not brought forward to diminish what has been done in the last 50 years, but to enhance awareness of how ideas and even mechanical ventilators change over time. This second part will describe how those ideas and mechanics changed into what we now call IMV in its many forms.
Pattern of Partial Edentulism According to Kennedy’s Classification among Patients Presenting in Tertiary Care Hospital of Taxilla
Authors: Rafiq Aamir , Qaiser Sumayia , Zehra Rizvi Syeda Sameen , Zahra Fatima Tu , Nisar Amna , Saeed Zirwah
Published: March 2022

Aim & Objective: This study was conducted with the goal to figure out the pattern of partially dentate arches in patients reporting to Dental Hospital of Taxilla. Methodology: The study is descriptive cross sectional that was focused on patients visiting the outpatient department of HITEC-IMS Dental College, Taxilla. A total of 224 patients, compromising both males and females, were randomly selected using convenience sampling. Age of the patients was 15-70 years. Informed consent was taken and patients were then visually examined and missing teeth were noted along with demographic information. Partially dentate arches were then classified on the basis of Kennedy’s classification. Collected data was evaluated by using SPSS software (27.0). Chi- square test was applied for analysis. Results: 224 patients were studied for the pattern of partial edentulism.44.6% patients were presented with partial edentulism in maxilla and 55.3% in mandible. Kennedy class I was 12.9%, Kennedy class II was 25.9%, Kennedy Class III was 54% and Kennedy class IV was 7.2% reported among presenting patients. 45.5% males and 54.5% females show pattern of partial edentulism with Kennedy Class III as the most prevalent class in both maxilla and mandible. Conclusion: Among the partially dentate arches Kennedy class III is more frequent in mandible than in maxilla. No notable association between pattern of partial edentulism and gender is established. Keywords: Kennedy’s Classification, Partial edentulism, Removable Partial Denture(RPD)
Late Paediatric Empyema Thoracic Decortication Using Muscle Sparing Axillary Skin Crease Incision (Msasci)
Authors: Qureshi Mumtaz Ahmed , Burki Sadia Asmat , Arsalan Muhammad Kashif , Hussain Abid , Chaudhry Abid Rafiq , Cheema Khadijah Ahmad
Published: March 2022

Objective: The aim of this study is to determine the effectiveness of muscle sparing axillary skin incision (MISASCI) among patients of late paediatric empyema thoracic were undergone decortication. Study Design: A prospective study Place and Duration: The study was conducted at Children Hospital and Institute of Child Health Lahore and Women and Children Hospital Rajjar, Charsada during the period from December 2020 to May 2021. Methods: Total 50 children of both genders were presented in this study. Patients were aged 1 month-12 years. Patients’ detailed demographics age, sex and weight were calculated after taking informed written consent from authorities. Patients had late paediatric empyema thoracic were enrolled. MSASCI was used for decortication among all cases. Effectiveness of incision was calculated post-operatively in terms of visibility and size of scar, intraoperative exposure and access to the lobes. Complete data was analyzed by SPSS 23.0 version. Results: There were 30 (60%) male and 20 (40%) females with mean age 7.14±7.44 years. Mean body weight of the children was 16.58±9.74 kg. We found pyopneumothorax in 20 (40%), followed by encysted empyema in 12 (24%), multiloculated empyema in 9 (18%), bilateral Empyema thorax in 5 (10%),and diaphragmatic hernia in 4 (8%). Adequate exposure was seen among 49 (98%) cases. Chest tube was removed within 5.87±4.54 days. Good lung expansion was found in 47 (94%) cases. Air leak was found among 6 (12%) cases. Frequency of scars was very low only among 4 (8%) cases. Conclusion: We concluded in this study that MSASCI was effective for decortication among patients of late paediatric empyema thoracic in terms of post-operative good lung expansion, adequate exposure with minimum numbers of scars and less complications i.e air leak in all cases. Keywords: MSASCI, Paediatric Empyema Thoracic, Decortication, Complications