bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomimicry of the Hawk Moth, Manduca sexta (L.), Produces an Improved Flapping-Wing Mechanism
Authors: Moses Kenneth , Willis Mark , Quinn Roger
Published: June 2020

Flapping-wing micro air vehicles (FWMAVs) that mimic the flight capabilities of insects have been sought for decades. Core to the vehicle’s flight capabilities is the mechanism that drives the wings to produce thrust and lift. This article describes a newly designed flapping-wing mechanism (FWM) inspired by the North American hawk moth, Manduca sexta. Moreover, the hardware, software, and experimental testing methods developed to measure the efficiency of insect-scale flapping-wing systems (i.e., the lift produced per unit of input power) are detailed. The new FWM weighs 1.2 grams without an actuator and wings attached, and its maximum dimensions are 21 × 24 × 11 mm. This FWM requires 402 mW of power to operate, amounting to a 48% power reduction when compared to a previous version. In addition, it generates 1.3 gram-force of lift at a flapping frequency of 21.6 Hz. Results show progress, but they have not yet met the power efficiency of the naturally occurring Manduca sexta. Plans to improve the technique for measuring efficiency are discussed as well as strategies to more closely mimic the efficiency of the Manduca sexta-inspired FWM.
Spatially Resolved Spectral Imaging by A THz-FEL
Authors: Irizawa Akinori , Fujimoto Masaki , Kawase Keigo , Kato Ryukou , Fujiwara Hidenori , Higashiya Atsushi , Macis Salvatore , Tomarchio Luca , Lupi Stefano , Marcelli Augusto , Suga Shigemasa
Published: June 2020

Using the unique characteristics of the free-electron-laser (FEL), we successfully performed high-sensitivity spectral imaging of different materials in the terahertz (THz) and far-infrared (FIR) domain. THz imaging at various wavelengths was achieved using in situ spectroscopy by means of this wavelength tunable and monochromatic source. In particular, owing to its large intensity and directionality, we could collect high-sensitivity transmission imaging of extremely low-transparency materials and three-dimensional objects in the 3–6 THz range. By accurately identifying the intrinsic absorption wavelength of organic and inorganic materials, we succeeded in the mapping of spatial distribution of individual components. This simple imaging technique using a focusing optics and a raster scan modality has made it possible to set up and carry out fast spectral imaging experiments on different materials in this radiation facility.
Entropy-Based Algorithms for Signal Processing
Authors: Jeon Gwanggil , Chehri Abdellah
Published: June 2020

Entropy, the key factor of information theory, is one of the most important research areas in computer science [...]
The Impacts of China–Africa Economic Relation on Factor Productivity of African Countries
Authors: Miao Miao , Yushi Jiang , Borojo Dinkneh Gebre
Published: June 2020

This study attempts to empirically examine the impacts of the China–Africa economic relationship on factor productivity. The two-step system Generalized method of moments (GMM) estimator is applied to analyze the impacts of the Africa–China economic relationship on factor productivity of 44 African countries controlling Africa–China trade, Chinese foreign direct investment (FDI), and aid allocation to African countries for the periods 2003–2017. The estimation strategy controls endogeneity concerns. Another novelty of this study is calculating total factor productivity (TFP) using the regression approach and driving capital stock data. Additionally, the institutional quality index of countries is derived using principal component analysis. The findings of this study refer that the impact of the China–Africa economic relationship on the TFP of African countries is conditional to the domestic institutional quality of African countries. The results imply that the productivity embodied by the Africa–China economic relationship should be backed by the domestic adaptive capacity to use the benefit of China–Africa economic relations to excel factor productivity. Hence, the capability of African countries to benefit from the China–Africa economic relationship to enhance factor productivity should improve the institutional quality.
A Design of Wide-Range and Low Phase Noise Linear Transconductance VCO with 193.76 dBc/Hz FoMT for mm-Wave 5G Transceivers
Authors: Hejazi Arash , Pu YoungGun , Lee Kang-Yoon
Published: June 2020

This paper presents a wide-range and low phase noise mm-Wave Voltage Controlled Oscillator (VCO) based on the transconductance linearization technique. The proposed technique eliminates the deep triode region of the active part of the VCO, and lowers the noise introduced by the gm-cell. The switch sizes inside the switched capacitor bank of the VCO are optimized to minimize the resistance of the switches while keeping the wide tuning range. A new layout technique shortens the routing of the VCO outputs, and lowers the parasitic inductance and resistance of the VCO routing. The presented method prevents the reduction of the quality factor of the tank due to the long routing. The proposed VCO achieves a discrete frequency tuning range, of 14 GHz to 18 GHz, through a linear coarse and middle switched capacitor array, and offers superior phase noise performance compared to recent state-of-the-art VCO architectures. The design is implemented in a 45 nm CMOS process and occupies a layout area (including output buffers) of 0.14 mm2. The power consumption of the VCO core is 24 mW from the power supply of 0.8 V. The post-layout simulation result shows the VCO achieves the phase noise performances of −87.2 dBc/Hz and −113 dBc/Hz, at 100 kHz and 1 MHz offset frequencies from the carrier frequency of 14 GHz, respectively. In an 18 GHz carrier frequency, the results are −87.4 dBc/Hz and −110 dBc/Hz, accordingly.
Framing in Renewable Energy Policies: A Glossary
Authors: Wolsink Maarten
Published: June 2020

The transformation of a power supply, a social-technical system suffering from a heavy lock-ins, requires structural adaptations which are extremely complex. All actors in social acceptance processes have either strong vested interests in the current system or are challenging these. In strategies developed by those actors, so-called ‘frames’ play a key role. These are biased problem definitions and mental shortcuts, tools to affect the course of decision-making processes. Examples are “clean coal”, “smart grid”, “base-load”, or “decentralized”. Framing is fundamental to political processes, including those of decision making on renewables. This review presents a glossary of significant frames used in social acceptance processes of renewables’ innovation in power supply systems. The identified frames are classified and presented with, in each entry, one significant frame discussed and analyzed in relation to its most associated frames. Overall, the contrast comes to the fore between the paradigm of the current heavy centralized and hierarchically managed power supply system, on the one hand, and the newly emerging concepts around distributed generation on the other hand. Within these two clusters and in between, certain frames are focused on issues of ownership and control of infrastructures, while others concern allocation of space for establishing infrastructure.
The Influence of Fe on the Structure and Hydrogen Sorption Properties of Ti-V-Based Metal Hydrides
Authors: Nygård Magnus M. , Sørby Magnus H. , Grimenes Arne A. , Hauback Bjørn C.
Published: June 2020

Ti-V-based metal hydrides have decent overall performance as hydrogen storage materials, but V is expensive and it is therefore tempting to replace it by less expensive ferrovanadium containing about 20% Fe. In the present work we have investigated how Fe influences the structure and hydrogen storage properties of (Ti0.7V0.3)1−zFez alloys with e r r o r t y p e c e z ∈ { 0 , 0.03, 0.06, 0.1, 0.2, 0.3} using synchrotron radiation powder X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry and manometric measurements performed in a Sieverts apparatus. The alloys form body-centered cubic (bcc) crystal structures for all considered values of z, and the addition of Fe causes the unit cell to contract. When exposed to hydrogen gas, the bcc alloys form face-centered cubic (fcc) hydrides if e r r o r t y p e c e z ≤ 0 . 1 while other hydrogen-containing phases are formed for higher Fe-contents. The hydrogen capacities of the fcc hydrides at 20 bar are not significantly influenced by the addition of Fe and reach 3.2(3) wt% in (Ti0.7V0.3)0.9Fe0.1H1.6(2). For higher Fe contents the hydrogen capacity is decreased. The absorption kinetics are fast and the reactions are complete within minutes when the alloys are exposed to 20 bar H2 at room temperature. Increasing Fe content reduces the desorption enthalpy, onset temperature and activation energy.
Thermal-Aware Virtual Machine Allocation for Heterogeneous Cloud Data Centers
Authors: Akbari Abbas , Khonsari Ahmad , Ghoreyshi Seyed Mohammad
Published: June 2020

In recent years, a large and growing body of literature has addressed the energy-efficient resource management problem in data centers. Due to the fact that cooling costs still remain the major portion of the total data center energy cost, thermal-aware resource management techniques have been employed to make additional energy savings. In this paper, we formulate the problem of minimizing the total energy consumption of a heterogeneous data center (MITEC) as a non-linear integer optimization problem. We consider both computing and cooling energy consumption and provide a thermal-aware Virtual Machine (VM) allocation heuristic based on the genetic algorithm. Experimental results show that, using the proposed formulation, up to 30 % energy saving is achieved compared to thermal-aware greedy algorithms and power-aware VM allocation heuristics.
Energy Efficiency of Manufacturing Processes and Systems—An Introduction
Authors: Salonitis Konstantinos
Published: June 2020

This Special Issue of Energies was devoted to the topic of “Energy Efficiency of Manufacturing Processes and Systems”. It attracted significant attention of scholars, practitioners, and policy-makers from all over the world. Eighteen papers on this topic were submitted between 2018 and 2020, and a total of 10 papers were published. Main topics included the energy efficiency improvement in both the manufacturing process and system levels. Furthermore, new methodologies and analysis approaches in developing energy efficiency were presented.
Extrusion-Cooking Modifies Physicochemical and Nutrition-Related Properties of Wheat Bran
Authors: Roye Chiara , Henrion Muriel , Chanvrier Hélène , De Roeck Karlien , De Bondt Yamina , Liberloo Inge , King Roberto , Courtin Christophe M.
Published: June 2020

The potential of extrusion-cooking to change the physicochemical characteristics of wheat bran, increase its nutritional value and decrease its recalcitrance towards fermentation was investigated in this study. The conditions in a twin-screw extruder were varied by changing screw configuration, moisture content and barrel temperature. The former was not previously investigated in studies on bran extrusion. Extrusion-cooking resulted in an increased water-holding capacity and extract viscosity of bran, suggesting shear-induced structure degradation and structure loosening due to steam explosion at the extruder outlet. Modelling showed that the extent of these modifications mainly correlates with the amount of specific mechanical energy (SME) input, which increases with an increasing number of work sections in the screw configuration and a decreasing moisture content and barrel temperature. Extrusion led to solubilisation of arabinoxylan and ferulic acid. Moreover, it led to starch melting and phytate degradation. Upon fermentation of the most modified sample using a human faecal inoculum, small numeric pH decreases and short-chain fatty acid production increases were observed compared to the control bran, while protein fermentation was decreased. Overall, extrusion-cooking can improve the nutrition-related properties of wheat bran, making it an interesting technique for the modification of bran before further use or consumption as an extruded end product.
Exploring Consumers’ Purchase Intention of an Innovation of the Agri-Food Industry: A Case of Artificial Meat
Authors: Shen You-Cheng , Chen Han-Shen
Published: June 2020

Green consumption is an emerging environmental topic receiving global attention. Because livestock production is a primary source of greenhouse gas emission, the “low-carbon diet” has become a new trend in the catering industry. Fast food companies have been launching vegetarian products because artificial meat requires less water and land resources than traditional livestock and has lower carbon emissions. This study explores the influence of consumers’ attitude, subjective norms (SNs), and perceived behavioral control (PBC) on their purchase intention for vegetarian burgers from the product knowledge (PK) and environmental concern (EC) perspectives. Based on the theory of planned behavior, the purchase intention of people from different food cultures to pay for fast food burgers is discussed. Five hundred questionnaires were distributed, of which 436 were valid. The results revealed that: (1) consumers’ SNs, PBC, and EC significantly affect purchase intention (PI), and SNs and PK have no significant relationship with PI; and (2) vegetarians are willing to pay higher prices than nonvegetarians. This study recommends that industry personnel should attempt to increase consumers’ knowledge regarding artificial meat and expand marketing channels to improve the convenience of purchasing artificial meat foods by conducting lectures and media promotion, respectively.
Difference between Female and Male Patients with Oral Squamous Cell Carcinoma: A Single-Center Retrospective Study in Taiwan
Authors: Lin Nan-Chin , Hsu Jui-Ting , Tsai Kuo-Yang
Published: June 2020

There is a distinct male predominance in head and neck cancers. The present study aimed to investigate the clinical and pathological features of male and female patients with oral squamous cell carcinoma (OSCC), and to simultaneously conduct a survival analysis. Patients (n = 2573) were identified between January 2008 and December 2018, and subsequently analyzed for characteristics such as age at squamous cell carcinoma diagnosis, lifestyle factors (smoking habit, betel nut chewing and alcohol consumption), pathological American Joint Committee on Cancer (AJCC) anatomic site, AJCC TNM stage, pathological recurrence factor and interval from first diagnosis to recurrence. A case-matched comparison between female (n = 122) and male (n = 2451) patients was conducted. Significant gender differences were noted in age at diagnosis, anatomic site of the tumor, smoking habit, betel nut chewing and alcohol consumption (p < 0.001). There were no significant gender differences in the other clinical and pathological characteristics and survival conditions. In conclusion, female patients with OSCC were older than male patients with OSCC, and mostly had tumors of the oral tongue. Once patients develop OSCC, there was no difference in survival between men and women in a Taiwanese population.
The Prevention and Management of COVID-19: Seeking a Practical and Timely Solution
Authors: Jindal Charulata , Kumar Sandeep , Sharma Sunil , Choi Yuk Ming , Efird Jimmy T.
Published: June 2020

We read with interest several manuscripts recently published in the International Journal of Environmental Research and Public Health (IJERPH) on the ongoing coronavirus pandemic. While these articles provide a well-rounded overview on the risk and current status of this virus, we herein add some relevant information on its etiology, prevention and management, especially for resource-limited healthcare systems. The use of protective actions is both complex and expensive. Affordable options are essential to respond to this and future viral outbreaks.
Association of Work Patterns and Periodontitis Prevalence in Korean Adults Aged 50 Years or Older: A Nationwide Representative Study
Authors: Ra Young Jin , Tak Young Jin , Kim Yun Jin , Lee Sang Yeoup , Lee Jeong Gyu , Yi Yu Hyeon , Cho Young Hye , Hwang Hye Rim , Lee Seung Hun , Park Eun Ju , Lee Young In
Published: June 2020

This study analyzed the relationship between the work pattern and the prevalence of periodontitis. We analyzed the data of 3320 adults (1779 men, 1543 women) aged 51–80 years from the Korean National Health and Nutrition Examination Survey (2013–2015). The work pattern was divided into two groups (regular and irregular). The periodontal status was assessed using the community periodontal index. We observed a statistically significant difference in the association between work patterns and prevalence of periodontitis in Korean women aged over 50 years. For female workers with irregular work patterns, the prevalence of periodontitis was lower than that in workers with regular work patterns by 10.3% (40.3% vs. 30.0%, p = 0.011). The annual health examination rate was significantly higher in the irregular group than in the regular group (for men 77.9% vs. 73.5%; p < 0.001, for women 76.4% vs. 75.9%; p < 0.001). In female workers with irregular work patterns, the annual dental examination rate was significantly higher than that in workers with a regular work pattern by 7.7% (34.3% vs. 26.6%, p = 0.043). In conclusion we found a statistically significant difference between the work patterns and prevalence of periodontitis in Korean women aged over 50 years.
Evaluating Physician Adherence to Antithrombotic Recommendations in Patients with Atrial Fibrillation: A Pathway to Better Medical Education
Authors: Vesa Ştefan Cristian , Vlaicu Sonia Irina , Sabin Octavia , Văcăraș Vitalie , Crișan Sorin , Istratoaie Sabina , Samantar Fatuma , Popa Daciana Elena , Macarie Antonia Eugenia , Buzoianu Anca Dana
Published: June 2020

Background: Atrial fibrillation is a major health problem due to the stroke risk associated with it. To reduce stroke risk, oral anticoagulants (OAC) are prescribed using the CHA2DS2-VASc (Congestive heart failure; Hypertension; Age ≥75 years; Diabetes Mellitus; Stroke; Vascular disease; Age 65–74 years; Sex category) risk score, a clinical probability assessment that includes a combination of risk factors predicting the probability of a stroke. Not all patients with high risk are receiving this treatment. The aim of this study was to assess physician adherence to clinical guidelines concerning the OAC treatment and to identify the factors that were associated with the decision to prescribe it. Methods: Registry data from 784 patients with non-valvular atrial fibrillation were evaluated in this retrospective cross-sectional study. Demographic data, subtype of AF, comorbidities associated with higher stroke and bleeding risk, and antithrombotic treatment received were recorded. We compared stroke and bleeding risk in patients with and without OAC treatment to determine if the clinicians followed guidelines: prescribed when necessary and abstained when not needed. Results: OAC treatment was administered in 617 (78.7%) patients. Of the 167 patients who did not receive OAC, 161 (96.4%) were undertreated according to their risk score, as opposed to those who received OAC in which the percentage of overtreated was 3.2%. Most undertreated patients (60.5%, p < 0.001) were with paroxysmal atrial fibrillation subtype. Conclusions: The decision to use anticoagulants for stroke prevention was based on the type of atrial fibrillation, rather than on the risk of stroke as quantified by CHA2DS2-VASc as per the recommended guidelines.
The Emerging Role of Innate Immunity in Chronic Kidney Diseases
Authors: Tang Philip Chiu-Tsun , Zhang Ying-Ying , Chan Max Kam-Kwan , Lam Winson Wing-Yin , Chung Jeff Yat-Fai , Kang Wei , To Ka-Fai , Lan Hui-Yao , Tang Patrick Ming-Kuen
Published: June 2020

Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue fibrosis that finally results in an irreversible end-stage renal disease (ESRD). Renal inflammation recruits and activates immunocytes, which largely promotes tissue scarring of the diseased kidney. Importantly, studies have suggested a crucial role of innate immunity in the pathologic basis of kidney diseases. This review provides an update of both clinical and experimental information, focused on how innate immune signaling contributes to renal fibrogenesis. A better understanding of the underlying mechanisms may uncover a novel therapeutic strategy for ESRD.
Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications
Authors: Filardi Tiziana , Catanzaro Giuseppina , Mardente Stefania , Zicari Alessandra , Santangelo Carmela , Lenzi Andrea , Morano Susanna , Ferretti Elisabetta
Published: June 2020

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the second or third trimester of pregnancy. GDM can lead to short-term and long-term complications both in the mother and in the offspring. Diagnosing and treating this condition is therefore of great importance to avoid poor pregnancy outcomes. There is increasing interest in finding new markers with potential diagnostic, prognostic and therapeutic utility in GDM. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs and circular RNAs, are critically involved in metabolic processes and their dysregulated expression has been reported in several pathological contexts. The aberrant expression of several circulating or placenta-related ncRNAs has been linked to insulin resistance and β-cell dysfunction, the key pathophysiological features of GDM. Furthermore, significant associations between altered ncRNA profiles and GDM-related complications, such as macrosomia or trophoblast dysfunction, have been observed. Remarkably, the deregulation of ncRNAs, which might be linked to a detrimental intrauterine environment, can lead to changes in the expression of target genes in the offspring, possibly contributing to the development of long-term GDM-related complications, such as metabolic and cardiovascular diseases. In this review, all the recent findings on ncRNAs and GDM are summarized, particularly focusing on the molecular aspects and the pathophysiological implications of this complex relationship.
Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations in ALS and SBMA
Authors: Limanaqi Fiona , Busceti Carla Letizia , Biagioni Francesca , Cantini Federica , Lenzi Paola , Fornai Francesco
Published: June 2020

The coordinated activities of autophagy and the ubiquitin proteasome system (UPS) are key to preventing the aggregation and toxicity of misfold-prone proteins which manifest in a number of neurodegenerative disorders. These include proteins which are encoded by genes containing nucleotide repeat expansions. In the present review we focus on the overlapping role of autophagy and the UPS in repeat expansion proteotoxicity associated with chromosome 9 open reading frame 72 (C9ORF72) and androgen receptor (AR) genes, which are implicated in two motor neuron disorders, amyotrophic lateral sclerosis (ALS) and spinal-bulbar muscular atrophy (SBMA), respectively. At baseline, both C9ORF72 and AR regulate autophagy, while their aberrantly-expanded isoforms may lead to a failure in both autophagy and the UPS, further promoting protein aggregation and toxicity within motor neurons and skeletal muscles. Besides proteotoxicity, autophagy and UPS alterations are also implicated in neuromuscular junction (NMJ) alterations, which occur early in both ALS and SBMA. In fact, autophagy and the UPS intermingle with endocytic/secretory pathways to regulate axonal homeostasis and neurotransmission by interacting with key proteins which operate at the NMJ, such as agrin, acetylcholine receptors (AChRs), and adrenergic beta2 receptors (B2-ARs). Thus, alterations of autophagy and the UPS configure as a common hallmark in both ALS and SBMA disease progression. The findings here discussed may contribute to disclosing overlapping molecular mechanisms which are associated with a failure in cell-clearing systems in ALS and SBMA.
Repeated Freezing Procedures Preserve Structural and Functional Properties of Amniotic Membrane for Application in Ophthalmology
Authors: Pogozhykh Olena , Hofmann Nicola , Gryshkov Oleksandr , von Kaisenberg Constantin , Mueller Marc , Glasmacher Birgit , Pogozhykh Denys , Börgel Martin , Blasczyk Rainer , Figueiredo Constança
Published: June 2020

For decades, the unique regenerative properties of the human amniotic membrane (hAM) have been successfully utilized in ophthalmology. As a directly applied biomaterial, the hAM should be available in a ready to use manner in clinical settings. However, an extended period of time is obligatory for performing quality and safety tests. Hence, the low temperature storage of the hAM is a virtually inevitable step in the chain from donor retrieval to patient application. At the same time, the impact of subzero temperatures carries an increased risk of irreversible alterations of the structure and composition of biological objects. In the present study, we performed a comprehensive analysis of the hAM as a medicinal product; this is intended for a novel strategy of application in ophthalmology requiring a GMP production protocol including double freezing–thawing cycles. We compared clinically relevant parameters, such as levels of growth factors and extracellular matrix proteins content, morphology, ultrastructure and mechanical properties, before and after one and two freezing cycles. It was found that epidermal growth factor (EGF), transforming growth factor beta 1 (TGF-β1), hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF), hyaluronic acid, and laminin could be detected in all studied conditions without significant differences. Additionally, histological and ultrastructure analysis, as well as transparency and mechanical tests, demonstrated that properties of the hAM required to support therapeutic efficacy in ophthalmology are not impaired by dual freezing.
A Novel Approach to Optimize Hot Melt Impregnation in Terms of Amorphization Efficiency
Authors: Garbera Kamil , Ciura Krzesimir , Sawicki Wiesław
Published: June 2020

In this study, an innovative methodology to optimize amorphization during the hot melt impregnation (HMI) process was proposed. The novelty of this report revolves around the use of thermal analysis in combination with design of experiments (DoEs) to reduce residual crystallinity during the HMI process. As a model formulation, a mixture of ibuprofen (IBU) and Neusilin was used. The main aim of the study was to identify the critical process parameters of HMI and determine their optimal values to assure a robust impregnation process and possibly the highest possible amorphization rate of IBU. In order to realize this, a DoE approach was proposed based on a face-centered composite design involving three factors. The IBU/Neusilin ratio, the feeding rate, and the screw speed were considered as variables, while the residual crystallinity level of IBU, determined using differential scanning calorimetry (DSC), was measured as the response. Additionally, the stability of IBU under HMI was analyzed using high-performance liquid chromatography to estimate the extent of potential degradation. In order to verify the correctness of the DoE model, tested extrudates were manufactured by HMI and the obtained extrudates were thoroughly examined using scanning electron micrography, X-ray powder diffraction, and DSC.
Fe2+ Ions Alleviate the Symptom of Citrus Greening Disease
Authors: Inoue Haruhiko , Yamashita-Muraki Sakiko , Fujiwara Kanako , Honda Kayoko , Ono Hiroki , Nonaka Takamasa , Kato Yuichi , Matsuyama Tomoya , Sugano Shoji , Suzuki Motofumi , Masaoka Yoshikuni
Published: June 2020

Citrus greening (CG) is among the most devastating citrus diseases worldwide. CG-infected trees exhibit interveinal chlorotic leaves due to iron (Fe) deficiency derived from CG; thus, Fe content is lower in infected leaves than in healthy leaves. In this study, we demonstrated that the foliar application of Fe2+ relieves the symptom of CG infection in citrus trees. We applied Fe2+ and citrate to the leaves of infected rough lemon plants. Following this treatment, a reduction in the number of yellow symptomatic leaves was observed, and their growth was restored. Using chlorophyll content as an index, we screened for effective Fe complexes and found that a high ratio of citrate to Fe2+ in the applied solution led to effects against CG in Shikuwasa trees. A high proportion of Fe2+ to total Fe was another key factor explaining the effectiveness of the solution in CG infection, indicating the importance of Fe2+ absorption into plant cells. We confirmed the proportion of Fe2+ to total Fe through the high correlation of reflectometry data via a triazine reaction and X-ray absorption fine structure analysis. These results demonstrate that the foliar application of a high-Fe2+ citrate solution can restore the growth of CG diseased trees.
NGT1 Is Essential for N-Acetylglucosamine-Mediated Filamentous Growth Inhibition and HXK1 Functions as a Positive Regulator of Filamentous Growth in Candida tropicalis
Authors: Zhang Qiuyu , Xu Li , Yuan Sheng , Zhou Qinghua , Wang Xuxia , Wang Lei , Hu Zhiming , Yan Yunjun
Published: June 2020

Candida tropicalis is a pathogenic fungus that can cause opportunistic infections in humans. The ability of Candida species to transition between yeast and filamentous growth forms is essential to their ability to undergo environmental adaptation and to maintain virulence. In other fungal species, such as Candida albicans, N-acetylglucosamine (GlcNAc) can induce filamentous growth, whereas it suppresses such growth in C. tropicalis. In the present study, we found that knocking out the GlcNA-specific transporter gene NGT1 was sufficient to enhance C. tropicalis filamentous growth on Lee’s plus GlcNAc medium. This suggests that GlcNAc uptake into C. tropicalis cells is essential to the disruption of mycelial growth. As such, we further studied how GlcNAc catabolism-related genes were able to influence C. tropicalis filamentation. We found that HXK1 overexpression drove filamentous growth on Lee’s media containing glucose and GlcNAc, whereas the deletion of the same gene disrupted this filamentous growth. Interestingly, the deletion of the DAC1 or NAG1 genes impaired C. tropicalis growth on Lee’s plus GlcNAc plates. Overall, these results indicate that HXK1 can serve as a positive regulator of filamentous growth, with excess GlcNAc-6-PO4 accumulation being toxic to C. tropicalis. These findings may highlight novel therapeutic targets worthy of future investigation.
Body-Related Attentional Bias among Men with High and Low Muscularity Dissatisfaction
Authors: Porras-Garcia Bruno , Exposito-Sanz Erik , Ferrer-Garcia Marta , Castillero-Mimenza Oscar , Gutiérrez-Maldonado José
Published: June 2020

Previous studies have found gender differences in body-related attentional bias (AB), with women showing AB towards weight-related body parts. However, few studies have assessed the relationship between body-related AB and muscularity dissatisfaction (MD) in men. This study aimed to assess the presence of muscle-related AB in men, using a combination of a virtual reality (VR) embodiment-based technique and eye-tracking (ET) technology. Twenty men with high MD and 20 with low MD, owned a virtual avatar that had the same silhouette and body mass index as the participant. To analyze the gaze data, muscle-related areas of interest (M-AOIs) and nonmuscle-related areas of interest (NM-AOIs) were defined. The complete fixation time and the number of fixations on each AOI were recorded. Mixed between (group)-within (AOI_condition) analyses of variance showed a statistically significant interaction between group and time (p < 0.05) in both AB measures. Follow-up analyses revealed an AB towards M-AOIs only in men with high MD. Overall, men with high MD spent more time looking and displayed a higher number of fixations on M-AOIs, specifically the chest and shoulders, compared to men with low MD. This study provides new information about the relationship between MD and body-related AB in men. Combining VR with ET technologies presents interesting opportunities in the study of body image in men.
Erythropoietin, Fibroblast Growth Factor 23, and Death After Kidney Transplantation
Authors: Eisenga Michele F. , De Jong Maarten A. , Leaf David E. , Nolte Ilja M. , De Borst Martin H. , Bakker Stephan J. L. , Gaillard Carlo A. J. M.
Published: June 2020

Elevated levels of erythropoietin (EPO) are associated with an increased risk of death in renal transplant recipients (RTRs), but the underlying mechanisms remain unclear. Emerging data suggest that EPO stimulates production of the phosphaturic hormone fibroblast growth factor 23 (FGF23), another strong risk factor for death in RTRs. We hypothesized that the hitherto unexplained association between EPO levels and adverse outcomes may be attributable to increased levels of FGF23. We included 579 RTRs (age 51 ± 12 years, 55% males) from the TransplantLines Insulin Resistance and Inflammation Cohort study (NCT03272854). During a follow-up of 7.0 years, 121 RTRs died, of which 62 were due to cardiovascular cause. In multivariable Cox regression analysis, EPO was independently associated with all-cause (HR, 1.66; 95% CI 1.16–2.36; P = 0.005) and cardiovascular death (HR, 1.87; 95% CI 1.14–3.06; P = 0.01). However, the associations were abrogated following adjustment for FGF23 (HR, 1.28; 95% CI 0.87–1.88; P = 0.20, and HR, 1.45; 95% CI 0.84–2.48; P = 0.18, respectively). In subsequent mediation analysis, FGF23 mediated 72% and 50% of the association between EPO and all-cause and cardiovascular death, respectively. Our results underline the strong relationship between EPO and FGF23 physiology, and provide a potential mechanism underlying the relationship between increased EPO levels and adverse outcomes in RTRs.
Craniomandibular Disorders in Pregnant Women: An Epidemiological Survey
Authors: Fichera Grazia , Polizzi Alessandro , Scapellato Simone , Palazzo Giuseppe , Indelicato Francesco
Published: June 2020

Temporomandibular joint (TMJ) disorder has been reported to be 1.5 to two times more common in women than men. Such a gender-based difference could be attributed to behavioral, hormonal, anatomical, and psychological characteristics. Physiological hormonal differences between genders could be one of the possible explanations for the higher incidence of temporomandibular disorder (TMD) in women. As the plasma level of certain female hormones increases during gestation, it could be assumed that there is a higher prevalence of dysfunctional signs and symptoms in pregnant women. We performed an epidemiological survey based on screening for TMD in a group of 108 pregnant women and found that 72% of young women reported significant signs of TMJ disorders, 9% of the young women reported mild signs of TMJ disorders, and 19% of the included subjects reported no signs or symptoms of TMD. The presence of estrogen receptors in the temporomandibular joint of female baboons could be the basis of an explanation for the increased prevalence of dysfunction in young women reported in the literature and the high feedback we have seen of joint noises in pregnant women. On the basis of the present findings, it could be assumed that gestation period could represent a risk factor for craniomandibular dysfunctions.
Assessment of the Chemical Diversity and Potential Toxicity of Benthic Cyanobacterial Blooms in the Lagoon of Moorea Island (French Polynesia)
Authors: Bonnard Isabelle , Bornancin Louis , Dalle Klervi , Chinain Mireille , Zubia Mayalen , Banaigs Bernard , Roué Mélanie
Published: June 2020

In the last decades, an apparent increase in the frequency of benthic cyanobacterial blooms has occurred in coral reefs and tropical lagoons, possibly in part because of global change and anthropogenic activities. In the frame of the survey of marine benthic cyanobacteria proliferating in the lagoon of Moorea Island (French Polynesia), 15 blooms were collected, mainly involving three species—Anabaena sp.1, Lyngbya majuscula and Hydrocoleum majus-B. Their chemical fingerprints, obtained through high performance liquid chromatography combined with UV detection and mass spectrometry (HPLC-UV-MS) analyses, revealed a high extent of species-specificity. The chemical profile of Anabaena sp.1 was characterized by three major cyclic lipopeptides of the laxaphycin family, whereas the one of L. majuscula was characterized by a complex mixture including tiahuramides, trungapeptins and serinol-derived malyngamides. Toxicity screening analyses conducted on these cyanobacterial samples using Artemia salina and mouse neuroblastoma cell-based (CBA-N2a) cytotoxic assays failed to show any toxicity to a degree that would merit risk assessment with regard to public health. However, the apparently increasing presence of blooms of Lyngbya, Hydrocoleum, Anabaena or other benthic cyanobacteria on coral reefs in French Polynesia encourages the implementation of ad hoc monitoring programs for the surveillance of their proliferation and potential assessment of associated hazards.
Sediment Characteristics over Asymmetrical Tidal Sand Waves in the Dutch North Sea
Authors: Cheng Chiu Hwa , Soetaert Karline , Borsje Bas Wijnand
Published: June 2020

The behavior of asymmetrical bedforms, which include many tidal sand waves, is challenging to understand. They are of particular interest since they are mostly located within areas prone to offshore engineering activities. Most experimental investigations regarding asymmetrical bedforms consider the riverine environment, are limited to a single sand wave or a few scattered ones, and focus only on differences between crest and trough. Hardly any information is available on sediment compositional changes along asymmetrical tidal sand waves, despite their abundance offshore. An asymmetrical sand wave field located off the coast of Texel Island in the North Sea was studied in June and October 2017. A total of 102 sediment samples were collected over two seasons along a single transect that covered five complete sand waves to measure the grain size composition, organic carbon concentration, chlorophyll-a (chl-a) concentration, and sediment permeability. We found significant variations in these sediment parameters between the sand wave trough, crest, and gentle and steep slopes, including a difference in permeability of more than 2-fold, as well as a difference in median grain size exceeding 65 µm. Based on these characteristics, a sand wave can be divided into two discrete halves: gentle slope + crest and steep slope + trough. Our results indicate a distinct sediment-sorting process along the Texel sand waves, with a significant difference between the two halves of each sand wave. These data could serve as input for process-based modeling of the link between sediment-sorting processes and seabed morphodynamics, necessary to design offshore engineering projects.
Cryptocurrency Returns before and after the Introduction of Bitcoin Futures
Authors: Deniz Pinar , Stengos Thanasis
Published: June 2020

This paper examines the behaviour of Bitcoin returns and those of several other cryptocurrencies in the pre and post period of the introduction of the Bitcoin futures market. We use the principal component-guided sparse regression (PC-LASSO) model to analyze several sample sizes for the pre and post periods. Besides the neighbourhood of the break time, the current period is also investigated as returns start to recover after some time. Search intensity is observed to be the most important variable for Bitcoin for all periods, whereas for the other cryptocurrencies there are other variables that seem more important in the pre period, while search intensity still stands out in the post period. Furthermore, GARCH analyses suggest that search intensity increases the volatility of Bitcoin returns more in the post period than it does in the pre period. Our empirical findings suggest that the top five cryptocurrencies are substitutes before the launch of Bitcoin futures. However, this effect is lost, and moreover, there are spillover effects on altcoins during both the post and the recovery period. We find a spillover effect of the introduction of bitcoin futures on altcoins and this effect seems to persist during the recovery period.
Electrochemical Polishing of Austenitic Stainless Steels
Authors: Łyczkowska-Widłak Edyta , Lochyński Paweł , Nawrat Ginter
Published: June 2020

Improvement of the corrosion resistance capability, surface roughness, shining of stainless-steel surface elements after electrochemical polishing (EP) is one of the most important process characteristics. In this paper, the mechanism, obtained parameters, and results were studied on electropolishing of stainless-steel samples based on the review of the literature. The effects of the EP process parameters, especially current density, temperature, time, and the baths used were presented and compared among different studies. The samples made of stainless steel presented in the articles were analysed in terms of, among other things, surface roughness, resistance to corrosion, microhardness, and chemical composition. All results showed that the EP process greatly improved the analysed properties of the stainless-steel surface elements.
Synthesis, Optical, and Morphological Studies of ZnO Powders and Thin Films Fabricated by Wet Chemical Methods
Authors: Szczesny Robert , Scigala Aleksandra , Derkowska-Zielinska Beata , Skowronski Lukasz , Cassagne Christophe , Boudebs Georges , Viter Roman , Szłyk Edward
Published: June 2020

Zinc oxide nanoparticles were prepared from Zn5(CO3)2(OH)6 precursor, capped with poly(vinylpyrrolidone) (PVP), and annealed at 600 °C. The obtained powders were characterized by a powder X-ray diffraction (PXD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), UV–visible spectroscopy (UV–vis), Raman spectroscopy, infrared spectroscopy (IR), thermal analysis (TGA/DTA), and third-order nonlinear (NL) optical measurement. Morphological evaluation by TEM and SEM measurements indicated that the precursor micro-particles are ball-shaped structures composed of plates with a thickness of approximately 10 nm. ZnO thin films, as well as ZnO/polymer multilayer layouts, were obtained by wet chemical methods (spin- and dip-coating). Surface topography and morphology of the obtained films were studied by SEM and AFM microscopy. Films with uniformly distributed ZnO plates, due to the erosion of primary micro-particles were formed. The fabricated specimens were also analyzed using a spectroscopic ellipsometry in order to calculate dielectric function and film thickness.
Novel Bioderived Composites from Wastes
Authors: Petrella Andrea , Race Marco , Spasiano Danilo
Published: June 2020

The recycling and reuse of solid wastes can be considered important challenges for civil and environmental applications in the frame of a more sustainable model of development and the consumption of new resources and energy [...]
Kinetics Study in Parachute Landing Fall Technique by Comparing Professional and Amateur Malaysian Army Parachutists Using Kane’s Method
Authors: Aziz Syazwana , Rambely Azmin Sham , Gan Kok Beng , Wan Din Wan Rozita
Published: June 2020

This paper discusses the torque data during Parachute Landing Fall (PLF) activity on the sagittal plane by applying Kane’s method. The value of torque is determined in order to identify the movement of extension and flexion at every joint-segment on the parachutist during landing. Data were obtained from three professional and eighteen amateur parachutists, each with three consecutive landings. Quintic Biomechanics Software v26 was selected to capture motion analysis. The mathematical model for the PLF technique was presented based on a two-link kinematics open chain in a two-dimensional space using Kane’s method. The t-test result showed the p-value of torque at each joint between professionals and amateurs (p ≤ 0.05). According to the torque result, the professional parachutists extended their arm then flexion their elbow, shoulder, hip, knee and the ankle plantar flexion during the foot strike phase. The professional demonstrated a perfect PLF technique by identifying the flexion and extension on each joint segment that was involved during landing activity. The value of torque at each joint segment from professional parachutists may be used as a guideline for amateurs to perform optimal landing and minimise the injury.
Mortality Prediction Using SOFA Score in Critically Ill Surgical and Non-Surgical Patients: Which Parameter Is the Most Valuable?
Authors: Fuchs Piotr A. , Czech Iwona J. , Krzych Łukasz J.
Published: June 2020

Background and Objectives: assessment systems, such as the Sequential Organ Failure Assessment (SOFA) scale, are routinely used in intensive care units (ICUs) worldwide in order to predict patients’ outcome. We aimed to investigate SOFA’s usefulness in the prognostication of ICU mortality, including an analysis of the importance of its variables. Materials and Method: this single-centre observational study covered 905 patients that were admitted from 01.01.2015 to 31.12.2017 to a tertiary mixed ICU. The SOFA score was calculated on ICU admission. The worst results recorded within 24 h post admission were included into the calculation. The assessment was performed within subgroups of surgical (SP) and non-surgical patients (NSP). The subjects were followed-up until ICU discharge or death. ICU mortality was considered to be the outcome. Results: ICU mortality reached 35.4% (i.e., 320 deceased out of 905 ICU stays) and it was significantly lower in SP (n = 158, 25.3%) as compared with NSP (n = 162, 57.9%) (p < 0.001). A one-point increase in the SOFA score resulted in 1.35 times higher risk of death in the ICU in the whole studied population. Among the individual variables of SOFA, creatinine concentration was the most powerful in prognostication (OR = 1.92) in univariate analysis, while the Glasgow Coma Scale (GCS) score appeared to be the most important variable in multivariate analysis (OR = 1.8). Mortality prediction using consecutive SOFA variables differed between SP and NSP, as well as between men and women. Conclusions: The overall SOFA score predicts mortality to a similar extent in both surgical and non-surgical subjects. However, there are significant differences in prognostication using its particular components.
The Epidemiological Characteristics of the Korean Bat Paramyxovirus between 2016 and 2019
Authors: Jang Seong Sik , Noh Ji Yeong , Lo Van Thi , Choi Yong Gun , Yoon Sun-Woo , Jeong Dae Gwin , Kim Hye Kwon
Published: June 2020

Bats are considered reservoirs of severe emerging human pathogens. Notably, bats host major mammalian paramyxoviruses from the family Paramyxoviridae, order Mononegavirales. In this study, paramyxoviruses were investigated by reverse transcription semi-nested polymerase chain reaction (RT-semi-nested PCR) and reverse transcription polymerase chain reaction (RT-PCR), based on the RT-semi-nested PCR using the consensus paramyxovirus primers targeting the RNA dependent-RNA-polymerase (RdRp) region. In addition, RT-PCR was performed using newly designed primers targeting regions of the fusion protein (F) and hemagglutinin-neuraminidase (HN). The dominant bat species in the collection site of paramyxoviruses were Miniopterus schreibersii, Myotis macrodactylus, Myotis petax, and Rhinolophus ferrumequinum. Paramyxoviruses were detected in four samples in 2016 and six in 2019. Meanwhile, in samples collected in 2017 and 2018, no paramyxoviruses were detected. Phylogenetic analysis based on the partial nucleotide sequences of RdRp, F, and HN proteins suggested that the viruses belonged to the proposed genus Shaanvirus. In conclusion, this study revealed that bat paramyxoviruses in Korea belonged to a single genus and circulated sporadically in several provinces, including Chungbuk, Gangwon, Jeju, and Jeonnam.