bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legends from Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage
Authors: Wu Wenwen , Nishikawa Hiroyuki , Fukuda Takayo , Vittal Vinayak , Asano Masahide , Miyoshi Yasuo , Klevit Rachel E. , Ohta Tomohiko
Published: April 2023

Legends for Supplementary Figures S1-S13.
Supplementary Tables 1 through 4 and Supplementary Figures 1 and 2 from Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
Authors: Hoff Andreas M. , Alagaratnam Sharmini , Zhao Sen , Bruun Jarle , Andrews Peter W. , Lothe Ragnhild A. , Skotheim Rolf I.
Published: April 2023

Supplementary Table S1: primers used in RT-PCR and qRT-PCR validation and quantification of fusion genes and transcripts. Supplementary Table S2: Primers and probes for assays used in ddPCR linkage experiments. Supplementary Table S3: Pairs of sequencing reads. Supplementary Table S4: Candidate fusion transcript breakpoints validated by RT-PCR. Supplementary Figure S1: Sanger sequencing electropherograms validating fusion transcript breakpoints. Supplementary Figure S2: Milepost ddPCR linkage results of DNA from the NCI-H508, NTERA2 and 833KE cell lines.
Supplementary Materials and Methods from Agr2 Mediates Paracrine Effects on Stromal Fibroblasts That Promote Invasion by Gastric Signet-Ring Carcinoma Cells
Authors: Tsuji Tadahiro , Satoyoshi Rika , Aiba Namiko , Kubo Takanori , Yanagihara Kazuyoshi , Maeda Daichi , Goto Akiteru , Ishikawa Kazuo , Yashiro Masakazu , Tanaka Masamitsu
Published: April 2023

additional Materials and Methods
Supplementary Figure S4 from Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells
Authors: Bodogai Monica , Moritoh Kanako , Lee-Chang Catalina , Hollander Christine M. , Sherman-Baust Cheryl A. , Wersto Robert P. , Araki Yoshihiko , Miyoshi Ichiro , Yang Li , Trinchieri Giorgio , Biragyn Arya
Published: April 2023

tBreg-induced MDSC express multiple surface and intra-cellular markers.
Supplementary Figure S3 from Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells
Authors: Bodogai Monica , Moritoh Kanako , Lee-Chang Catalina , Hollander Christine M. , Sherman-Baust Cheryl A. , Wersto Robert P. , Araki Yoshihiko , Miyoshi Ichiro , Yang Li , Trinchieri Giorgio , Biragyn Arya
Published: April 2023

tBreg-induced education of MDSC inhibits production of cytokines in CD8+ cells.
Suppl Fig4 from Agr2 Mediates Paracrine Effects on Stromal Fibroblasts That Promote Invasion by Gastric Signet-Ring Carcinoma Cells
Authors: Tsuji Tadahiro , Satoyoshi Rika , Aiba Namiko , Kubo Takanori , Yanagihara Kazuyoshi , Maeda Daichi , Goto Akiteru , Ishikawa Kazuo , Yashiro Masakazu , Tanaka Masamitsu
Published: April 2023

Suppl Fig4. 3D gel-invasion assay and in vitro proliferation assay of MKN-74 cells.
Suppl Fig3 from Agr2 Mediates Paracrine Effects on Stromal Fibroblasts That Promote Invasion by Gastric Signet-Ring Carcinoma Cells
Authors: Tsuji Tadahiro , Satoyoshi Rika , Aiba Namiko , Kubo Takanori , Yanagihara Kazuyoshi , Maeda Daichi , Goto Akiteru , Ishikawa Kazuo , Yashiro Masakazu , Tanaka Masamitsu
Published: April 2023

Suppl Fig3. 3D gel-invasion assay using NFs and other gastric cancer cell lines.
Supplementary Methods from Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells
Authors: Bhattacharya Rajat , Ye Xiang-Cang , Wang Rui , Ling Xia , McManus Madonna , Fan Fan , Boulbes Delphine , Ellis Lee M.
Published: April 2023

Description of additional methods and procedures used in the study.
Supplementary Table S1 from Stromal Fibroblasts Induce CCL20 through IL6/C/EBPβ to Support the Recruitment of Th17 Cells during Cervical Cancer Progression
Authors: Walch-Rückheim Barbara , Mavrova Russalina , Henning Melanie , Vicinus Benjamin , Kim Yoo-Jin , Bohle Rainer Maria , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: April 2023

Immunoreactive Score (IRS) according to Remmele & Stegner.
Supplementary Materials and Methods from Stromal Fibroblasts Induce CCL20 through IL6/C/EBPβ to Support the Recruitment of Th17 Cells during Cervical Cancer Progression
Authors: Walch-Rückheim Barbara , Mavrova Russalina , Henning Melanie , Vicinus Benjamin , Kim Yoo-Jin , Bohle Rainer Maria , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: April 2023

Supplementary Materials and Methods
PMA stimulation induces C/EBPβ in NECF and CCL20 expression. from Stromal Fibroblasts Induce CCL20 through IL6/C/EBPβ to Support the Recruitment of Th17 Cells during Cervical Cancer Progression
Authors: Walch-Rückheim Barbara , Mavrova Russalina , Henning Melanie , Vicinus Benjamin , Kim Yoo-Jin , Bohle Rainer Maria , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: April 2023

(A) NECF were stimulated with 50 µg/ml PMA or medium for 24h. Whole cell extracts were analyzed for C/EBPβ expression by Western blot. Shown is one experiment out of n=3, quantification represents n=3. (B) NECF were stimulated with 50 µg/ml PMA (lower panel) or medium (upper panel) for 24h and co-stained with DAPI (blue), anti-Vimentin (red) and anti-C/EBPβ (green) and analyzed in Immunofluorescence. (C) NECF were stimulated with 50 µg/ml PMA or medium for 24h. Supernatants were collected and analyzed for CCL20 protein expression. Shown are the values{plus minus}SD averaged from n=3 experiments performed in triplicates.
Figure S7 from Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors
Authors: An Ningfei , Xiong Ying , LaRue Amanda C. , Kraft Andrew S. , Cen Bo
Published: April 2023

Overexpression of Pim kinases contributes to increased protein translation in resistant cells through controlling cap-independent translation.
Figure S6 from Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors
Authors: An Ningfei , Xiong Ying , LaRue Amanda C. , Kraft Andrew S. , Cen Bo
Published: April 2023

Pim upregulation is necessary to confer resistance to MET inhibitors in MET-dependent cellular model.
Figure S5 from Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors
Authors: An Ningfei , Xiong Ying , LaRue Amanda C. , Kraft Andrew S. , Cen Bo
Published: April 2023

Bcl-2 mediates resistance to MET inhibitors.
Supplementary Table 2 from CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival
Authors: Ullrich Nico , Heinemann Anja , Nilewski Elena , Scheffrahn Inka , Klode Joachim , Scherag André , Schadendorf Dirk , Singer Bernhard B. , Helfrich Iris
Published: April 2023

Supplementary Table 2. Quantitative expression analyses of CEACAM1 splice variants in melanoma biopsies.
Figure S4 from Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors
Authors: An Ningfei , Xiong Ying , LaRue Amanda C. , Kraft Andrew S. , Cen Bo
Published: April 2023

Pim inhibitors synergistically enhance the efficacy of MET inhibitors.
Supplementary Information from CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival
Authors: Ullrich Nico , Heinemann Anja , Nilewski Elena , Scheffrahn Inka , Klode Joachim , Scherag André , Schadendorf Dirk , Singer Bernhard B. , Helfrich Iris
Published: April 2023

Supplementary Information. Detailed material information, methods and supplemental figure legends
Supplementary Figure 2 from CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival
Authors: Ullrich Nico , Heinemann Anja , Nilewski Elena , Scheffrahn Inka , Klode Joachim , Scherag André , Schadendorf Dirk , Singer Bernhard B. , Helfrich Iris
Published: April 2023

Supplementary Figure 2. CEACAM1 isoforms also modulate surface expression of DNMA-1 ligands in an isoform specific mode of action.
Supplementary Table S2 from Epigenetic Silencing of miR-490-3p Reactivates the Chromatin Remodeler SMARCD1 to Promote Helicobacter pylori–Induced Gastric Carcinogenesis
Authors: Shen Jing , Xiao Zhangang , Wu William K.K. , Wang Maggie H. , To Ka F. , Chen Yangchao , Yang Weiqin , Li May S.M. , Shin Vivian Y. , Tong Joanna H. , Kang Wei , Zhang Lin , Li Minxing , Wang Lin , Lu Lan , Chan Ruby L.Y. , Wong Sunny H. , Yu Jun , Chan Matthew T.V. , Chan Francis K.L. , Sung Joseph J.Y. , Cheng Alfred S.L. , Cho Chi H.
Published: April 2023

Supplementary Table S2: Distribution of patient characteristics by survival status.
Supplementary Table S2 from PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets
Authors: Scortegagna Marzia , Lau Eric , Zhang Tongwu , Feng Yongmei , Sereduk Chris , Yin Hongwei , De Surya K. , Meeth Katrina , Platt James T. , Langdon Casey G. , Halaban Ruth , Pellecchia Maurizio , Davies Michael A. , Brown Kevin , Stern David F. , Bosenberg Marcus , Ronai Ze'ev A.
Published: April 2023

Supplementary Table S2. Outline of genetic changes in the tumors and cell lines used.
Supplementary Figure S5 from Epigenetic Silencing of miR-490-3p Reactivates the Chromatin Remodeler SMARCD1 to Promote Helicobacter pylori–Induced Gastric Carcinogenesis
Authors: Shen Jing , Xiao Zhangang , Wu William K.K. , Wang Maggie H. , To Ka F. , Chen Yangchao , Yang Weiqin , Li May S.M. , Shin Vivian Y. , Tong Joanna H. , Kang Wei , Zhang Lin , Li Minxing , Wang Lin , Lu Lan , Chan Ruby L.Y. , Wong Sunny H. , Yu Jun , Chan Matthew T.V. , Chan Francis K.L. , Sung Joseph J.Y. , Cheng Alfred S.L. , Cho Chi H.
Published: April 2023

Supplementary Figure S5: Attenuation of tumor-suppressing effects of miR-490-3p by SMARCD1 overexpression.
Supplementary Figure S3 from Epigenetic Silencing of miR-490-3p Reactivates the Chromatin Remodeler SMARCD1 to Promote Helicobacter pylori–Induced Gastric Carcinogenesis
Authors: Shen Jing , Xiao Zhangang , Wu William K.K. , Wang Maggie H. , To Ka F. , Chen Yangchao , Yang Weiqin , Li May S.M. , Shin Vivian Y. , Tong Joanna H. , Kang Wei , Zhang Lin , Li Minxing , Wang Lin , Lu Lan , Chan Ruby L.Y. , Wong Sunny H. , Yu Jun , Chan Matthew T.V. , Chan Francis K.L. , Sung Joseph J.Y. , Cheng Alfred S.L. , Cho Chi H.
Published: April 2023

Supplementary Figure S3: Overexpression of SMARCD1 but not PCBP2 in gastric cancer cell lines.
Supplemental Tables S1-S4 from An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy
Authors: Tavaré Richard , Escuin-Ordinas Helena , Mok Stephen , McCracken Melissa N. , Zettlitz Kirstin A. , Salazar Felix B. , Witte Owen N. , Ribas Antoni , Wu Anna M.
Published: April 2023

Supplemental Tables S1-S4: Ex vivo biodistribution of 89Zr-malDFO-169 cDb in wt and CD8-blocked ARK mice (S1); Ex vivo biodistribution of 89Zr-malDFO-169 cDb in the adoptive T cell transfer model (S2); Ex vivo biodistribution of 89Zr-malDFO-169 cDb in the anti-CD137/CT26 immunotherapy model (S3); 89Zr-malDFO-169 cDb ex vivo biodistribution analysis at 22 h post-injection of anti-PD-L1 partial responding (S4).
Supplemental Methods and References from An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy
Authors: Tavaré Richard , Escuin-Ordinas Helena , Mok Stephen , McCracken Melissa N. , Zettlitz Kirstin A. , Salazar Felix B. , Witte Owen N. , Ribas Antoni , Wu Anna M.
Published: April 2023

Supplemental Methods and References: Description of additional methods and procedures used in the study. Also includes Supplemental References.
Supplemental Figures S1-S5 from An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy
Authors: Tavaré Richard , Escuin-Ordinas Helena , Mok Stephen , McCracken Melissa N. , Zettlitz Kirstin A. , Salazar Felix B. , Witte Owen N. , Ribas Antoni , Wu Anna M.
Published: April 2023

Supplemental Figures S1-S5: Anti-CD8 immunoPET of 89Zr-malDFO-169 cDb in the OT-I adoptive T cell therapy model: transverse images (S1); Alterations in inguinal lymph node and spleen weights after differing immunotherapeutic treatment (S2); Anti-CD8 immunoPET of 89Zr-malDFO-169 cDb in the CT26/anti-CD137 immunotherapy model: transverse images (S3); CD8 IHC on untreated CT26 xenografts (S4); Anti-CD8 immunoPET of 89Zr-malDFO-169 cDb in the CT26/anti-PD-L1 immunotherapy model: transverse images (S5).
Supplementary Material and Methods, Figure Legends S1-6 from Reprogramming of the ERRα and ERα Target Gene Landscape Triggers Tamoxifen Resistance in Breast Cancer
Authors: Thewes Verena , Simon Ronald , Schroeter Petra , Schlotter Magdalena , Anzeneder Tobias , Büttner Reinhard , Benes Vladimir , Sauter Guido , Burwinkel Barbara , Nicholson Robert I. , Sinn Hans-Peter , Schneeweiss Andreas , Deuschle Ulrich , Zapatka Marc , Heck Stefanie , Lichter Peter
Published: April 2023

Supplementary Material and Methods, Figure Legends S1-6. Supplementary Material and Methods, Figure Legends S1-6.
Supplementary Figure S6 from The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment
Authors: Qian Yanyan , Yuan Jupeng , Hu Huili , Yang Qifeng , Li Jisheng , Zhang Shuqian , Jiang Baichun , Shao Changshun , Gong Yaoqin
Published: April 2023

Supplementary Figure S6. p-PKCβII is downregulated in MDSCs lacking CUL4B.
Supplementary Figure S5 from The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment
Authors: Qian Yanyan , Yuan Jupeng , Hu Huili , Yang Qifeng , Li Jisheng , Zhang Shuqian , Jiang Baichun , Shao Changshun , Gong Yaoqin
Published: April 2023

Supplementary Figure S5. p-PDK1 and PTEN in MDSCs are not affected by lack of CUL4B.
Supplementary Figure S3 from The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment
Authors: Qian Yanyan , Yuan Jupeng , Hu Huili , Yang Qifeng , Li Jisheng , Zhang Shuqian , Jiang Baichun , Shao Changshun , Gong Yaoqin
Published: April 2023

Supplementary Figure S3. Increased generation and impaired maturation of CD11b+Gr-1+ cells in naïve Cul4b CKO mice.
Supplementary Figure S3 from Reprogramming of the ERRα and ERα Target Gene Landscape Triggers Tamoxifen Resistance in Breast Cancer
Authors: Thewes Verena , Simon Ronald , Schroeter Petra , Schlotter Magdalena , Anzeneder Tobias , Büttner Reinhard , Benes Vladimir , Sauter Guido , Burwinkel Barbara , Nicholson Robert I. , Sinn Hans-Peter , Schneeweiss Andreas , Deuschle Ulrich , Zapatka Marc , Heck Stefanie , Lichter Peter
Published: April 2023

Supplementary Figure S3. ChIP-Seq validation by qRT-PCR.
Supplementary Figure S1 from The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment
Authors: Qian Yanyan , Yuan Jupeng , Hu Huili , Yang Qifeng , Li Jisheng , Zhang Shuqian , Jiang Baichun , Shao Changshun , Gong Yaoqin
Published: April 2023

Supplementary Figure S1. Lack of CUL4B in hematopoietic system promotes the growth of tumor grafts and the accumulation of MDSCs.
Supplementary Figure S1 from Reprogramming of the ERRα and ERα Target Gene Landscape Triggers Tamoxifen Resistance in Breast Cancer
Authors: Thewes Verena , Simon Ronald , Schroeter Petra , Schlotter Magdalena , Anzeneder Tobias , Büttner Reinhard , Benes Vladimir , Sauter Guido , Burwinkel Barbara , Nicholson Robert I. , Sinn Hans-Peter , Schneeweiss Andreas , Deuschle Ulrich , Zapatka Marc , Heck Stefanie , Lichter Peter
Published: April 2023

Supplementary Figure S1. Effects of anti-estrogens on cell proliferation in MCF-7 #Wt, #TamR and #FulvR cells.
Supplementary Figure 6 from Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression
Authors: Anz David , Rapp Moritz , Eiber Stephan , Koelzer Viktor H. , Thaler Raffael , Haubner Sascha , Knott Max , Nagel Sarah , Golic Michaela , Wiedemann Gabriela M. , Bauernfeind Franz , Wurzenberger Cornelia , Hornung Veit , Scholz Christoph , Mayr Doris , Rothenfusser Simon , Endres Stefan , Bourquin Carole
Published: April 2023

Supplementary Figure 6-Type I interferon is a key mediator in the process of CCL22 suppression and tumor regression.
Supplementary Figure 4 from Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression
Authors: Anz David , Rapp Moritz , Eiber Stephan , Koelzer Viktor H. , Thaler Raffael , Haubner Sascha , Knott Max , Nagel Sarah , Golic Michaela , Wiedemann Gabriela M. , Bauernfeind Franz , Wurzenberger Cornelia , Hornung Veit , Scholz Christoph , Mayr Doris , Rothenfusser Simon , Endres Stefan , Bourquin Carole
Published: April 2023

Supplementary Figure 4-Inducible secretion of CCL22 by CT26-CCL22dox cells.
Supplementary Figure 3 from Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression
Authors: Anz David , Rapp Moritz , Eiber Stephan , Koelzer Viktor H. , Thaler Raffael , Haubner Sascha , Knott Max , Nagel Sarah , Golic Michaela , Wiedemann Gabriela M. , Bauernfeind Franz , Wurzenberger Cornelia , Hornung Veit , Scholz Christoph , Mayr Doris , Rothenfusser Simon , Endres Stefan , Bourquin Carole
Published: April 2023

Supplementary Figure 3-Correlation (corr) of intratumoral FoxP3+ cells and CCL22 levels in CT26 tumors from untreated mice.
Supplementary Figure S1 from Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development
Authors: Wang Jian , Cao Ziquan , Zhang Xing-Mei , Nakamura Masaki , Sun Meili , Hartman Johan , Harris Robert A. , Sun Yuping , Cao Yihai
Published: April 2023

Supplementary Figure S1. Diagram of the multicolor zebrafish tumor model
Legends for Supplementary Figures from Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression
Authors: Anz David , Rapp Moritz , Eiber Stephan , Koelzer Viktor H. , Thaler Raffael , Haubner Sascha , Knott Max , Nagel Sarah , Golic Michaela , Wiedemann Gabriela M. , Bauernfeind Franz , Wurzenberger Cornelia , Hornung Veit , Scholz Christoph , Mayr Doris , Rothenfusser Simon , Endres Stefan , Bourquin Carole
Published: April 2023

Legends for Supplementary Figures
Supplementary Figure S1 from eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor Cells
Authors: Avdulov Svetlana , Herrera Jeremy , Smith Karen , Peterson Mark , Gomez-Garcia Jose R. , Beadnell Thomas C. , Schwertfeger Kathryn L. , Benyumov Alexey O. , Manivel J. Carlos , Li Shunan , Bielinsky Anja-Katrin , Yee Douglas , Bitterman Peter B. , Polunovsky Vitaly A.
Published: April 2023

Supplementary Fig. S1. Generation of WAP-4E transgenic mice.
Legends to Supplementary Figure from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: April 2023

Legends to Supplementary Figures
Figure S3 from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: April 2023

Figure S3. Effect of P2X7R deletion on VEGF release. A, in vitro VEGF release from wt or P2X7R-silenced B16 cells. B, intra-tumor VEGF content of B16-wt or P2X7R-silenced tumors grown in wt or P2X7R-KO mice. VEGF was measured by ELISA. A, * p < 0.05 for B16 shRNA vs B16-wt. B, * p < 0.05 for P2X7R-wt + B16 shRNA vs P2X7R-wt + B16-wt; {section sign}{section sign} p < 0.01 for P2X7R-KO + B16 shRNA vs P2X7R-KO + B16-wt. C-F, VEGF staining of tumors from P2X7R-KO (C and D) or wt (E and F) mice. Specimens were fixed and stained with the anti-VEGF Ab as described in Materials and Methods.
Figure S1 from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: April 2023

Figure S1. Characterization of P2X7R shRNA B16 cells. A, densitometry of P2X7R protein expression. B, representative Western blot. C, Fura-2 measurement of Benzoyl ATP (BzATP)-triggered intracellular Ca2+ increase. D, Averages intracellular Ca2+ increases in wt and P2X7R-silenced B16 cells. Data are averages + SEM, n = 5. ***, p < 0.001. E, rate of proliferation of wt and P2X7R-silenced B16 cell cultures. Intracellular Ca2+ changes and proliferation rates were measured as described in Adinolfi et al., 2005, Mol Biol Cell 16:3260-3272.
Supplementary Methods and Reference from miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
Authors: Shi Xu-Bao , Ma Ai-Hong , Xue Lingru , Li Meimei , Nguyen Hao G. , Yang Joy C. , Tepper Clifford G. , Gandour-Edwards Regina , Evans Christopher P. , Kung Hsing-Jien , deVere White Ralph W.
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary Reference.
Supplementary Figure S3 from miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
Authors: Shi Xu-Bao , Ma Ai-Hong , Xue Lingru , Li Meimei , Nguyen Hao G. , Yang Joy C. , Tepper Clifford G. , Gandour-Edwards Regina , Evans Christopher P. , Kung Hsing-Jien , deVere White Ralph W.
Published: April 2023

Immunostaining of AR-V7 in miR-124-treated 22Rv1-EnzR cells.
Supplemental Figure S2 from Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
Authors: Crompton Joseph G. , Sukumar Madhusudhanan , Roychoudhuri Rahul , Clever David , Gros Alena , Eil Robert L. , Tran Eric , Hanada Ken-ichi , Yu Zhiya , Palmer Douglas C. , Kerkar Sid P. , Michalek Ryan D. , Upham Trevor , Leonardi Anthony , Acquavella Nicolas , Wang Ena , Marincola Francesco M. , Gattinoni Luca , Muranski Pawel , Sundrud Mark S. , Klebanoff Christopher A. , Rosenberg Steven A. , Fearon Douglas T. , Restifo Nicholas P.
Published: April 2023

Supplemental Figure S2. CD8+ tumor-infiltrating lymhphocytes (TIL) isolated from patient with melanoma have reduced phosphorylation of Akt T308 and GSK3βS9 in presence of Akt inhibitor.
Supplementary Materials and Methods from Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion
Authors: Wong Sophie Y. , Ulrich Theresa A. , Deleyrolle Loic P. , MacKay Joanna L. , Lin Jung-Ming G. , Martuscello Regina T. , Jundi Musa A. , Reynolds Brent A. , Kumar Sanjay
Published: April 2023

Supplementary Materials and Methods. Description of additional methods and procedures used in the study.
Supplementary Tables S1-S11 from UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas
Authors: Wong Stephen Q. , Waldeck Kelly , Vergara Ismael A. , Schröder Jan , Madore Jason , Wilmott James S. , Colebatch Andrew J. , De Paoli-Iseppi Ricardo , Li Jason , Lupat Richard , Semple Timothy , Arnau Gisela Mir , Fellowes Andrew , Leonard J. Helen , Hruby George , Mann Graham J. , Thompson John F. , Cullinane Carleen , Johnston Meredith , Shackleton Mark , Sandhu Shahneen , Bowtell David D.L. , Johnstone Ricky W. , Fox Stephen B. , McArthur Grant A. , Papenfuss Anthony T. , Scolyer Richard A. , Gill Anthony J. , Hicks Rodney J. , Tothill Richard W.
Published: April 2023

MCC Patient characteristics (S1); Extension cohort of MCCs (S2); List of genes represented on the targeted sequencing panel (S3); Performance metrics for targeted sequencing and low coverage WGS (S4); Validation of mutations by orthogonal genotyping methods (S5); Immunohistochemistry scores for MCCs (S6); SNV and Indels called from targeted sequencing (S7); Mutational burden with respect to copy number changes through low coverage whole genome sequencing (S8); Gene level copy-number from LC-WGS (S9); Copies and viral integration sites for MCV positive MCCs (S10); Drug sensitivity data for 3 MCC cell lines (S11).
Supplementary Methods and References from UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas
Authors: Wong Stephen Q. , Waldeck Kelly , Vergara Ismael A. , Schröder Jan , Madore Jason , Wilmott James S. , Colebatch Andrew J. , De Paoli-Iseppi Ricardo , Li Jason , Lupat Richard , Semple Timothy , Arnau Gisela Mir , Fellowes Andrew , Leonard J. Helen , Hruby George , Mann Graham J. , Thompson John F. , Cullinane Carleen , Johnston Meredith , Shackleton Mark , Sandhu Shahneen , Bowtell David D.L. , Johnstone Ricky W. , Fox Stephen B. , McArthur Grant A. , Papenfuss Anthony T. , Scolyer Richard A. , Gill Anthony J. , Hicks Rodney J. , Tothill Richard W.
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure S3 from Mass Spectrometry–Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer
Authors: Cook John A. , Chandramouli Gadisetti V.R. , Anver Miriam R. , Sowers Anastasia L. , Thetford Angela , Krausz Kristopher W. , Gonzalez Frank J. , Mitchell James B. , Patterson Andrew D.
Published: April 2023

Temporal profiles of a few selected metabolites.
Supplementary Table 3 from Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival
Authors: den Hollander Petra , Rawls Kathryn , Tsimelzon Anna , Shepherd Jonathan , Mazumdar Abhijit , Hill Jamal , Fuqua Suzanne A.W. , Chang Jenny C. , Osborne C. Kent , Hilsenbeck Susan G. , Mills Gordon B. , Brown Powel H.
Published: April 2023

Supp Tab 3 - Excel spreadsheet containing gene list used to identify phosphatases and phosphatase-interacting proteins.
Supplementary Table 1 from Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival
Authors: den Hollander Petra , Rawls Kathryn , Tsimelzon Anna , Shepherd Jonathan , Mazumdar Abhijit , Hill Jamal , Fuqua Suzanne A.W. , Chang Jenny C. , Osborne C. Kent , Hilsenbeck Susan G. , Mills Gordon B. , Brown Powel H.
Published: April 2023

Supp Tab 1 - Tissue samples used for this study were obtained from the Lester and Sue Smith Breast Cancer Tumor bank at Baylor College of Medicine. We studied 102 breast tumors from this bank that were collected from sites in the US and Europe. Study demographics define the majority of the population to be postmenopausal women, 97% Caucasian, and the median subject age to be 53 years. In this cohort, 95% of the tumors were invasive ductal carcinomas, 47% presented no lymph node involvement, all were without metastasis, and 76% of study participants had tumors {greater than or equal to}2cm3 at the time of diagnosis. The ER and PR status of each tissue sample was determined through immunohistochemistry (IHC) analysis, and HER2 status by fluorescent in-situ hybridization (FISH). This identified 49 ER-positive tumors and 53 triple-negative tumors. Of the ER-positive breast cancers, 12 tumors were also HER2-positive (24%), and 42 PR positive (86%).
Supplementary Figure 5 from Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival
Authors: den Hollander Petra , Rawls Kathryn , Tsimelzon Anna , Shepherd Jonathan , Mazumdar Abhijit , Hill Jamal , Fuqua Suzanne A.W. , Chang Jenny C. , Osborne C. Kent , Hilsenbeck Susan G. , Mills Gordon B. , Brown Powel H.
Published: April 2023

Supp Fig 5 - A) PTP4A3 and Myc amplification status in Luminal A/B and Basal-like breast cancers from TCGA data set. B) PTP4A3 and Myc amplification status in ovarian cancer from TCGA data set. C) Map detailing the location of the genes analyzed for gene amplification. D) Comparative analysis of PTP4A3 gene copy number and expression levels
Supplementary Figure 4 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: April 2023

IGF1R inhibition synergizes with PI3Kβ inhibition in WM-266-4, but not in A-375. A) Synergistic proliferation inhibition upon PI3K/IGF1R inhibitor combination in WM-266-4 cells. WM-266-4 cells were treated with increasing concentrations of PI3Ki and IGF1Ri as single-agents or in combination with a fixed concentration of 1.1μM IGF1Ri. The data shown represents the mean ({plus minus}SEM) of two replicates. B) + C) Determination of PI3K/IGF1R inhibitor synergy in WM-266-4 (B) and A-375 (C) using proliferation assays. Dose matrices highlight percentages of proliferation inhibition relative to DMSO with 100 indicating complete block of proliferation and >100 indicative of cell death. SS, synergy score. PI3Kβi1/2=rac-KIN-193/GSK-2636771, panPI3Ki=GDC0941, PI3Kαi=BYL719, IGF1Ri=AEW541
Supplementary information from Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism
Authors: Hollander Lindsay , Guo Xiaojia , Velazquez Heino , Chang John , Safirstein Robert , Kluger Harriet , Cha Charles , Desir Gary V.
Published: April 2023

More detailed description of some of the methods.
Supplementary method from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: April 2023

This file contains supplementary description regarding the materials and methods we used in this study, including lentivirus construction and cell transfection, real-time PCR, reagents, tissue microarray and immunohistochemistry, immunoprecipitation, western blot analysis, immunofluorescence, wound healing, transwell migration, and invasion assays.
Supplementary Table 3 from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: April 2023

Supplementary Table 3: Univariate analysis of overall survival at 5-year follow-up.
Supplementary Figure 3 from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: April 2023

Supplementary Figure 3: PDLIM1 binds E-cadherin/β-catenin complex and attenuates EGF-induced EMT.
Table S1 from Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas
Authors: Henrich Kai-Oliver , Bender Sebastian , Saadati Maral , Dreidax Daniel , Gartlgruber Moritz , Shao Chunxuan , Herrmann Carl , Wiesenfarth Manuel , Parzonka Martha , Wehrmann Lea , Fischer Matthias , Duffy David J. , Bell Emma , Torkov Alica , Schmezer Peter , Plass Christoph , Höfer Thomas , Benner Axel , Pfister Stefan M. , Westermann Frank
Published: April 2023

Cox proportional hazards regression for overall survival (105 neuroblastomas)
Supplementary Figure Legends from Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas
Authors: Henrich Kai-Oliver , Bender Sebastian , Saadati Maral , Dreidax Daniel , Gartlgruber Moritz , Shao Chunxuan , Herrmann Carl , Wiesenfarth Manuel , Parzonka Martha , Wehrmann Lea , Fischer Matthias , Duffy David J. , Bell Emma , Torkov Alica , Schmezer Peter , Plass Christoph , Höfer Thomas , Benner Axel , Pfister Stefan M. , Westermann Frank
Published: April 2023

Legends for Supplementary Figures S1-S8.
Supplemental Figure 7 from Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity
Authors: Kim Dong Joon , Roh Eunmiri , Lee Mee-Hyun , Oi Naomi , Lim Do Young , Kim Myoung Ok , Cho Yong-Yeon , Pugliese Angelo , Shim Jung-Hyun , Chen Hanyong , Cho Eun Jin , Kim Jong-Eun , Kang Sun Chul , Paul Souren , Kang Hee Eun , Jung Ji Won , Lee Sung-Young , Kim Sung-Hyun , Reddy Kanamata , Yeom Young Il , Bode Ann M. , Dong Zigang
Published: April 2023

The effect of putrescine re-addition on intracellular polyamine levels in herbacetin- or DFMO-treated cells. Colon cancer cells were treated with herbacetin or DFMO for 24 h and then putresine was or was not added for 30 min and intracellular polyamines were extracted and analyzed. All data are represented as means {plus minus} S.D. of triplicate values from 3 independent experiments. The asterisk (*) indicates a significant effect (p < 0.05) of herbacetin or DFMO alone compared to cells with added putrescine treatment.
Supplementary Figure S8 from Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma
Authors: Takayama Yusuke , Hattori Noboru , Hamada Hironobu , Masuda Takeshi , Omori Keitaro , Akita Shin , Iwamoto Hiroshi , Fujitaka Kazunori , Kohno Nobuoki
Published: April 2023

Effects of SK-216 on the phosphorylation of ERK1/2 and AKT
Supplementary Figure S7 from Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma
Authors: Takayama Yusuke , Hattori Noboru , Hamada Hironobu , Masuda Takeshi , Omori Keitaro , Akita Shin , Iwamoto Hiroshi , Fujitaka Kazunori , Kohno Nobuoki
Published: April 2023

Effects of PAI-1 silencing on the degrees of proliferation, migration, and tube formation of HUVECs
Supplementary Figure S3 from Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma
Authors: Takayama Yusuke , Hattori Noboru , Hamada Hironobu , Masuda Takeshi , Omori Keitaro , Akita Shin , Iwamoto Hiroshi , Fujitaka Kazunori , Kohno Nobuoki
Published: April 2023

Effects of SK-216 on subcutaneous tumors in SCID mice inoculated with MPM cells
Supplementary Table S4 from Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205
Authors: Hirata Hiroshi , Hinoda Yuji , Shahryari Varahram , Deng Guoren , Nakajima Koichi , Tabatabai Z. Laura , Ishii Nobuhisa , Dahiya Rajvir
Published: April 2023

Association of Ezh2 expression with clinical parameters in RCC patients.
Supplementary Figure S2 from Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205
Authors: Hirata Hiroshi , Hinoda Yuji , Shahryari Varahram , Deng Guoren , Nakajima Koichi , Tabatabai Z. Laura , Ishii Nobuhisa , Dahiya Rajvir
Published: April 2023

Schematic representation of ChIP primers located in the promoter of the E-Cadherin gene.
Supplemental Figure S3 from Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model
Authors: Sacco Antonio , Roccaro Aldo M. , Ma Dongdong , Shi Jiantao , Mishima Yuji , Moschetta Michele , Chiarini Marco , Munshi Nikhil , Handin Robert I. , Ghobrial Irene M.
Published: April 2023

Efficacy of CXCR4-, VLA4- and FAK-silencing in MM cells. Efficacy of CXCR4 silencing and CXCR4 over-expression in WM cells.
Supplemental Figure S1 from Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model
Authors: Sacco Antonio , Roccaro Aldo M. , Ma Dongdong , Shi Jiantao , Mishima Yuji , Moschetta Michele , Chiarini Marco , Munshi Nikhil , Handin Robert I. , Ghobrial Irene M.
Published: April 2023

DiD- and DiO-labeled MM.1S cells do not differ for their ability to migrate to the CHT niches.
Supplementary Tables from miR-892b Silencing Activates NF-κB and Promotes Aggressiveness in Breast Cancer
Authors: Jiang Lili , Yu Liang , Zhang Xin , Lei Fangyong , Wang Lan , Liu Xiangxia , Wu Shu , Zhu Jinrong , Wu Geyan , Cao Lixue , Liu Aibin , Song Libing , Li Jun
Published: April 2023

Clinical information on the samples and Correlation between the clinicopathological features and expression of miR-892b
Supplementary Methods from miR-892b Silencing Activates NF-κB and Promotes Aggressiveness in Breast Cancer
Authors: Jiang Lili , Yu Liang , Zhang Xin , Lei Fangyong , Wang Lan , Liu Xiangxia , Wu Shu , Zhu Jinrong , Wu Geyan , Cao Lixue , Liu Aibin , Song Libing , Li Jun
Published: April 2023

Supplemental materials and methods
Supplementary Figure 3 from miR-892b Silencing Activates NF-κB and Promotes Aggressiveness in Breast Cancer
Authors: Jiang Lili , Yu Liang , Zhang Xin , Lei Fangyong , Wang Lan , Liu Xiangxia , Wu Shu , Zhu Jinrong , Wu Geyan , Cao Lixue , Liu Aibin , Song Libing , Li Jun
Published: April 2023

Supplementary Figure 3. Downregulation of miR-892b promotes the aggressiveness of breast cancer cells in vivo.
Supplementary table 2 from Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism
Authors: Jia Min , Andreassen Trygve , Jensen Lasse , Bathen Tone Frost , Sinha Indranil , Gao Hui , Zhao Chunyan , Haldosen Lars-Arne , Cao Yihai , Girnita Leonard , Moestue Siver Andreas , Dahlman-Wright Karin
Published: April 2023

The metabolites levels identified by NMR, which are normalized by protein amount
Supplementary Methods and Materials from FOXD1–ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells
Authors: Cheng Peng , Wang Jia , Waghmare Indrayani , Sartini Stefania , Coviello Vito , Zhang Zhuo , Kim Sung-Hak , Mohyeldin Ahmed , Pavlyukov Marat S. , Minata Mutsuko , Valentim Claudia L.L. , Chhipa Rishi Raj , Bhat Krishna P.L. , Dasgupta Biplab , La Motta Concettina , Kango-Singh Madhuri , Nakano Ichiro
Published: April 2023

Supplementary methods and materials
Supplementary Table 3 from Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients
Authors: Osman Abdullah A. , Neskey David M. , Katsonis Panagiotis , Patel Ameeta A. , Ward Alexandra M. , Hsu Teng-Kuei , Hicks Stephanie C. , McDonald Thomas O. , Ow Thomas J. , Alves Marcus Ortega , Pickering Curtis R. , Skinner Heath D. , Zhao Mei , Sturgis Eric M. , Kies Merrill S. , El-Naggar Adel , Perrone Federica , Licitra Lisa , Bossi Paolo , Kimmel Marek , Frederick Mitchell J. , Lichtarge Olivier , Myers Jeffrey N.
Published: April 2023

Supplementary Table 3: Cox proportional hazard regression afterward backward selection and adjusting for EA score for overall survival.
Supplemental Figure 4 from Jak1–STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in Tumorigenesis
Authors: Quick Laura , Young Robert , Henrich Ian C. , Wang Xiaoke , Asmann Yan W. , Oliveira Andre M. , Chou Margaret M.
Published: April 2023

CRISPR cell lines
Figure S6 from Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma
Authors: Ciesla Maciej , Marona Paulina , Kozakowska Magdalena , Jez Mateusz , Seczynska Marta , Loboda Agnieszka , Bukowska-Strakova Karolina , Szade Agata , Walawender Magdalena , Kusior Magdalena , Stepniewski Jacek , Szade Krzysztof , Krist Bart , Yagensky Oleksandr , Urbanik Aleksandra , Kazanowska Bernarda , Dulak Jozef , Jozkowicz Alicja
Published: April 2023

Comparison of eRMS (RD) and aRMS (RH5, RH18, RH28) cell lines cultured under standard conditions.
Figure S3 from Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma
Authors: Ciesla Maciej , Marona Paulina , Kozakowska Magdalena , Jez Mateusz , Seczynska Marta , Loboda Agnieszka , Bukowska-Strakova Karolina , Szade Agata , Walawender Magdalena , Kusior Magdalena , Stepniewski Jacek , Szade Krzysztof , Krist Bart , Yagensky Oleksandr , Urbanik Aleksandra , Kazanowska Bernarda , Dulak Jozef , Jozkowicz Alicja
Published: April 2023

Effect of SnPP (10 μM, 24 h) on RMS cell lines. A - Expression of cMET, HGF, CXCR4 and SDF1 mRNAs in CW9019 aRMS cell line.
Supplementary Figures from Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers
Authors: Lawson Campbell D. , Fan Cheng , Mitin Natalia , Baker Nicole M. , George Samuel D. , Graham David M. , Perou Charles M. , Burridge Keith , Der Channing J. , Rossman Kent L.
Published: April 2023

Supplementary Figures S1-S4 Supplementary Figure S1 Western blots showing knockdown of ArhGAP11A or RacGAP1. Supplementary Figure S2 ArhGAP11A and RacGAP1 are both required for proliferation of HER2-enriched and luminal B breast cancer cell lines. Supplementary Figure S3 ArhGAP11A and RacGAP1 regulate cell spreading. Supplementary Figure S4 Constitutively active Rac1 and Cdc42 do not affect BLBC proliferation.
Supplemental text - unmarked from Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
Authors: Cheng Gang , Zielonka Jacek , Ouari Olivier , Lopez Marcos , McAllister Donna , Boyle Kathleen , Barrios Christy S. , Weber James J. , Johnson Bryon D. , Hardy Micael , Dwinell Michael B. , Kalyanaraman Balaraman
Published: April 2023

Supplemental text - unmarked
Supplemental figures from Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
Authors: Cheng Gang , Zielonka Jacek , Ouari Olivier , Lopez Marcos , McAllister Donna , Boyle Kathleen , Barrios Christy S. , Weber James J. , Johnson Bryon D. , Hardy Micael , Dwinell Michael B. , Kalyanaraman Balaraman
Published: April 2023

Supplemental Figure 1: Chemical structures of mitochondria-targeted metformin analogs and the synthetic pathway. Supplemental Figure 2: Effects of Met and Mito-Met10 on proliferation of mouse pancreatic cancer cells. Supplemental Figure 3: The effects of Mito-Met10, Met and other mitochondria-targeted agents (MTAs) on intracellular ATP level and cell death in MiaPaCa-2 cells. Supplemental Figure 4: Mito-Met10, but not control long chain compound (Dec-TPP+), exhibits selectivity in inhibition of cancer cell viability. Supplemental Figure 5: Effects of Mito-Met2 and Mito-Met6 on PDAC proliferation. Supplemental Figure 6: Intracellular concentrations of Mito-Met10 in cancer and normal cells. Supplemental Figure 7: Intracellular redox signaling in Mito-Met10-treated PDAC cells. Supplemental Figure 8: Measurement of respiratory activity in permeabilized cells using extracellular flux analysis and effects of Mito-Met10 and Met on mitochondrial complex I activity. Supplemental Figure 9: Mito-Met10 and metformin directly inhibit pyruvate-driven, but not succinate-driven, respiration in permeabilized cells. Supplemental Figure 10: High concentrations of Mito-Met10 induce cellular oxidants in HPNE cells. Supplemental Figure 11: Tissue accumulation of Mito-Met10 in in vivo FC-1242-luc orthotopic mouse model.
Supplementary Mov. 2 from Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix
Authors: Grossman Moran , Ben-Chetrit Nir , Zhuravlev Alina , Afik Ran , Bassat Elad , Solomonov Inna , Yarden Yosef , Sagi Irit
Published: April 2023

Supplementary Mov. 2 from Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix
Supplemental Figures S1-S14 from Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages
Authors: Zhao Jun-Long , Huang Fei , He Fei , Gao Chun-Chen , Liang Shi-Qian , Ma Peng-Fei , Dong Guang-Ying , Han Hua , Qin Hong-Yan
Published: April 2023

Figure S1: Expression of Notch ligands and receptors in macrophages during in vitro differentiation and activation. Figure S2: Activation of Notch signaling in macrophages repressed the growth of transplanted B16F melanoma tumors. Figure S3: Activation of Notch signaling by conditional NIC expression in macrophages did not change the number of macrophages, but reduced the number of MDSCs and increased the number of CD8+ T-cells in transplanted tumors. Figure S4: miR-125a expression in BM cells and macrophages. Figure S5: miR-125a is a downstream molecule to Notch signaling in macrophages. Figure S6: Activation of Notch signaling with immobilized mD1R in macrophages promoted M1 polarization. Figure S7: Characterization of the miR-125a gene and its enhancer. Figure S8: The sequence of the first intron enhancer of Spaca6A. Figure S9: miR-125a enhanced phagocytosis of differentially activated macrophages. Figure S10: Notch signaling regulated M1 and M2 macrophage polarization. Figure S11: miR-125a regulated M1 macrophages through targeting FIH1. Figure S12: miR-125a repressed M2 macrophages through targeting IRF4. Figure S13: Self-amplification of miR-125a expression through RYBP/YY1. Figure S14: A model of the Notch signaling-mediated regulation of TAMs through miR-125a.
Table S1 from miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
Authors: Orso Francesca , Quirico Lorena , Virga Federico , Penna Elisa , Dettori Daniela , Cimino Daniela , Coppo Roberto , Grassi Elena , Elia Angela Rita , Brusa Davide , Deaglio Silvia , Brizzi Maria Felice , Stadler Michael B. , Provero Paolo , Caselle Michele , Taverna Daniela
Published: April 2023

miR-214 and miR-148b sponge sequences
Figure S9 from miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
Authors: Orso Francesca , Quirico Lorena , Virga Federico , Penna Elisa , Dettori Daniela , Cimino Daniela , Coppo Roberto , Grassi Elena , Elia Angela Rita , Brusa Davide , Deaglio Silvia , Brizzi Maria Felice , Stadler Michael B. , Provero Paolo , Caselle Michele , Taverna Daniela
Published: April 2023

miR-214 and miR-148b affect migration and invasion ability
Figure S8 from miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
Authors: Orso Francesca , Quirico Lorena , Virga Federico , Penna Elisa , Dettori Daniela , Cimino Daniela , Coppo Roberto , Grassi Elena , Elia Angela Rita , Brusa Davide , Deaglio Silvia , Brizzi Maria Felice , Stadler Michael B. , Provero Paolo , Caselle Michele , Taverna Daniela
Published: April 2023

miR-214 and miR-148b do not significantly affect proliferation
Figure S2 from miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
Authors: Orso Francesca , Quirico Lorena , Virga Federico , Penna Elisa , Dettori Daniela , Cimino Daniela , Coppo Roberto , Grassi Elena , Elia Angela Rita , Brusa Davide , Deaglio Silvia , Brizzi Maria Felice , Stadler Michael B. , Provero Paolo , Caselle Michele , Taverna Daniela
Published: April 2023

miR-214 expression modulations in melanoma cells
Supplementary Table 1 from Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations
Authors: Riquelme Erick , Behrens Carmen , Lin Heather Y. , Simon George , Papadimitrakopoulou Vassiliki , Izzo Julie , Moran Cesar , Kalhor Neda , Lee J. Jack , Minna John D. , Wistuba Ignacio I.
Published: April 2023

Summary of the clinicopathological characteristics of the patients with lung adecarcinoma examined for EZH2 expression and KRAS mutations